bluuebunny/crossref_metadata_2025 huggingface dataset:
Abschied eines Schülers vom Meister. Der sog. Panegyricus Gregors des Wundertäters auf Origenes: ΛΟΓΟΣ ΧΑΡΙΣΤΗΡΙΟΣ – ΛΟΓΟΣ ΠΡΟΣΦΩΝΗΤΙΚΟΣ – ΛΟΓΟΣ ΣΥΝΤΑΚΤΙΚΟΣ
Authors: Renger Almut-Barbara
Published: June 2012

The speech of Gregory Thaumaturgus to the Christian scholar and theologian Origen (c. 238 C. E.) is a historical document of unusual importance, both in terms of its content, depicting the master-student relationship of the time from the perspective of the student, and in terms of form, providing an actual implementation of the theory of rhetoric that was a cornerstone of higher education. Yet disagreement persists to this day in the scholarly literature over the generic classification of this first example of Christian epideictic oratory. It is most frequently found categorized as a speech of thanksgiving, of praise, or of farewell. This paper discusses the grounds for the various definitions, examines the text itself in search of such grounds, and shows, in reference to two treatises on epideictic attributed to Menander Rhetor, why the most plausible classification is as a logos syntaktikos – a farewell speech, in which a traveler, by means of portraying and arousing emotion, laments the necessary parting and praises the person or people of whom leave is taken.
Maccus vortit barbare? Eine übersehene Lizenzstelle im iambischen Senar
Authors: Deufert Marcus
Published: June 2012

The Law of Hermann and Lachmann stipulates that in the iambo-trochaic verses of Roman drama the two shorts of a resolved element must not be the final syllables of a trisyllabic or longer word. The exceptions are covered by the ‘rule for places with licence’ (‘norma delle sedi con licenza’), for which a redefined and extended version is given in this paper. Its purpose is to show that a dactylic word can be placed behind the penthemimeral caesura in the iambic senarius. The paper discusses the transmitted evidence for this licence and argues that the place after the penthemimeral caesura in the iambic senarius corresponds to the place after the median diaeresis in the trochaic septenarius, a well established licence-place which permits dactylic words.
Maternal high-fat diet programs Wnt genes through histone modification in the liver of neonatal rats
Authors: Yang Ke-feng , Cai Wei , Xu Jia-li , Shi Wen
Published: June 2012

Maternal high-fat (HF) diets during gestation and lactation have been shown to contribute to metabolic disorders in offspring. Molecular and epigenetic mechanisms underlying this connection may be essential for the prevention and treatment of the fetal origins of metabolic diseases. The current study examined the impact of maternal HF diets on Wnt signaling and histone modification in offspring. Time-pregnant Sprague–Dawley rats were fed either control diet or HF diet during gestation and lactation and then the neonatal offspring of both groups were investigated. The neonatal offspring born to dams fed on HF diets exhibited increases in serum glucose and liver triglyceride levels. Maternal exposure to the HF diet also repressed the mRNA expression of Wnt1 and nuclear β-catenin protein in the liver of offspring. The altered Wnt1 gene expression may be due to the changes of acetylation of H4 at its promoter as well as acetylation of H4 and methylation of H3K9 at coding region. Maternal exposure to the HF diet induced suppression of the Wnt/β-catenin signaling pathway through histone modification, potentially increasing the risk of metabolic syndrome.
The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling
Authors: Staines Katherine A , MacRae Vicky E , Farquharson Colin
Published: June 2012

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structural characteristics and are primarily located in bone and dentin. Accumulating evidence has implicated the SIBLING proteins in matrix mineralisation. Therefore, in this review, we discuss the individual role that each of the SIBLING proteins has in this highly orchestrated process. In particular, we emphasise how the nature and extent of their proteolytic processing and post-translational modification affect their functional role. Finally, we describe the likely roles of the SIBLING proteins in clinical disorders of hypophosphataemia and their potential therapeutic use.
Jolly Jades, Lewd Ladies and Moral Muses
Authors: Collis Robert
Published: June 2012

This article argues that the range of female participation in the associational culture of fraternalism in early eighteenth-century Britain—in terms of class background, social setting and moral philosophy—was surprisingly rich and varied. In effect, such a claim complements the body of work written in the past two decades, by historians such as Steve Pincus, Brian Cowan, Markham Ellis and Helen Berry, vis-à-vis the place of women in the public sphere of the coffeehouse in post-Restoration and Augustan England. This hypothesis will be developed by outlining the active involvement of women in three distinct spheres of fraternal culture in early eighteenth-century Britain. First, I will explore the manner in which women participated in or mimicked the culture of alehouse clubbing in early eighteenth-century London. Second, I will emphasize the prominent role of aristocratic ladies in mixed bacchanalian and masquerade societies, including the Order of the Horn, The Hell-Fire Club and the Gallant Schemers, that met in several notable town houses or country retreats of the English and Scottish gentry. Lastly, a study will be made of the all-female Fair Intellectual Club, which was established in May 1717 in Edinburgh.
Food quality and food threshold: implications of food stoichiometry to competitive ability of herbivore plankton
Authors: Iwabuchi Tsubasa , Urabe Jotaro
Published: June 2012

Exploitative competition for food resources is considered to be an important factor determining the dominant species in communities. In such a competition, a threshold food concentration (TFC), where the growth rate becomes zero, is crucial in determination of competitive outcomes. In addition, recent studies on ecological stoichiometry have suggested that the TFC of a species would differ due to changes in food elements that limit growth. If the magnitude of change in TFC differs between species, competitive superiority among species may also change. The experiments showed that the rank order of the species in TFC changed according to the P content of food, suggesting that competitively superior species can vary with elemental composition of food. These results imply that as well as quantity, the elemental composition of food is important in exploitative competition, and the changes in elemental composition of food may be critical to shape an entire community structure.
Racial/Ethnic Disparities in HIV Diagnoses Among Persons Aged 50 Years and Older in 37 US States, 2005–2008
Authors: Linley Laurie , Prejean Joseph , An Qian , Chen Mi , Hall H. Irene
Published: June 2012

Objectives. We examined racial/ethnic disparities in HIV diagnosis rates for persons aged 50 years and older.

Methods. We analyzed surveillance data from the Centers for Disease Control and Prevention regarding HIV diagnoses during 2005 through 2008 in 37 states. Average annual rates of diagnoses were calculated for persons aged 50 years and older and compared with rates for persons aged 13 to 49 years.

Results. The average annual rate of diagnosis (per 100 000 persons) for older persons was 9.8. Rates among older Blacks (49.2) and Hispanics/Latinos (19.5) were 12.6 and 5.0 times, respectively, the rate among older Whites (3.9); rates among younger Blacks (102.5) and Hispanics/Latinos (39.0) were 7.7 and 2.9 times, respectively, the rate among younger Whites (13.3). Older persons were more likely than younger persons to receive a late HIV diagnosis (prevalence ratio = 1.5, P < .001).

Conclusions. Racial/ethnic disparities in HIV diagnosis rates are greater among persons aged 50 years and older than among younger persons. The greater HIV diagnosis rates in Blacks and later diagnosis among older persons of all races/ethnicities indicate a need to increase their awareness of risk factors for HIV infection.
TheLive Well, Be WellStudy: A Community-Based, Translational Lifestyle Program to Lower Diabetes Risk Factors in Ethnic Minority and Lower–Socioeconomic Status Adults
Authors: Kanaya Alka M. , Santoyo-Olsson Jasmine , Gregorich Steven , Grossman Melanie , Moore Tanya , Stewart Anita L.
Published: June 2012

Objectives. We evaluated a community-based, translational lifestyle program to reduce diabetes risk in lower–socioeconomic status (SES) and ethnic minority adults.

Methods. Through an academic–public health department partnership, community-dwelling adults at risk for diabetes were randomly assigned to individualized lifestyle counseling delivered primarily via telephone by health department counselors or a wait-list control group. Primary outcomes (6 and 12 months) were fasting glucose level, triglycerides, high- and low-density lipoprotein cholesterol, weight, waist circumference, and systolic blood pressure. Secondary outcomes included diet, physical activity, and health-related quality of life.

Results. Of the 230 participants, study retention was 92%. The 6-month group differences for weight and triglycerides were significant. The intervention group lost 2 pounds more than did the control group (P = .03) and had decreased triglyceride levels (difference in change, 23 mg/dL; P = .02). At 6 months, the intervention group consumed 7.7 fewer grams per day of fat (P = .05) and more fruits and vegetables (P = .02) than did control participants.

Conclusions. Despite challenges designing effective translational interventions for lower-SES and minority communities, this program modestly improved some diabetes risk factors. Thus, individualized, telephone-based models may be a promising alternative to group-based interventions.
Overcoming the Unhealthy Pursuit of Thinness: Reaction to the Québec Charter for a Healthy and Diverse Body Image
Authors: Gauvin Lise , Steiger Howard
Published: June 2012

Objectives. We examined the population reach, acceptability, and perceived potential of an initiative that developed a promotional tool for a healthy body image, the Québec Charter for a Healthy and Diverse Body Image. The Charter, developed through consensus building by a multisectoral, government-led task force, outlined actions to be undertaken by organizations or citizens to reduce media pressures favoring thinness.

Methods. Six months after the Charter’s launch, we surveyed 1003 Québec residents aged 18 years or older about their knowledge of the Charter, their willingness to adhere to it, and their perceptions of its potential.

Results. After minimal prompting, more than 35% of respondents recognized the Charter. About 33.7% were very favorable toward personally adhering to the Charter and 32.7% perceived the Charter as having high potential to sensitize people to negative consequences of disordered eating. Women showed greater likelihood and people with lesser education showed lower likelihood of spontaneous recognition.

Conclusions. An initiative involving the creation of a body image Charter reaches a substantial portion of adults and is viewed as acceptable and potentially influential.
Children’s Aerobic Fitness and Academic Achievement: A Longitudinal Examination of Students During Their Fifth and Seventh Grade Years
Authors: Wittberg Richard A. , Northrup Karen L. , Cottrell Lesley A.
Published: June 2012

Objectives. We assessed children’s potential differences in academic achievement based on aerobic fitness over a 2-year period.

Methods. The longitudinal study sample included 3 cohorts of students (n = 1725; 50.1% male) enrolled in a West Virginia public school system. Students received baseline fitness and academic assessments as fifth graders and at a 2-year follow-up assessment. We used FitnessGram to assess fitness in aerobic capacity and WESTEST, a criterion-based assessment, for academic performance.

Results. Students who stayed in the healthy fitness zone (HFZ) had significantly higher WESTEST scores than did students who stayed in the needs improvement zone (NIZ). Students who moved into or out of the HFZ occasionally had significantly higher WESTEST scores than did students who stayed in the NIZ, but they were rarely significantly lower than those of students who stayed in the HFZ.

Conclusions. Students’ aerobic capacity is associated with greater academic achievement as defined by standardized test scores. This advantage appears to be maintained over time, especially if the student stays in the HFZ.
Aging, Diabetes, and the Public Health System in the United States
Authors: Caspersen Carl J. , Thomas G. Darlene , Boseman Letia A. , Beckles Gloria L. A. , Albright Ann L.
Published: June 2012

Diabetes (diagnosed or undiagnosed) affects 10.9 million US adults aged 65 years and older. Almost 8 in 10 have some form of dysglycemia, according to tests for fasting glucose or hemoglobin A1c. Among this age group, diagnosed diabetes is projected to reach 26.7 million by 2050, or 55% of all diabetes cases. In 2007, older adults accounted for $64.8 billion (56%) of direct diabetes medical costs, $41.1 billion for institutional care alone. Complications, comorbid conditions, and geriatric syndromes affect diabetes care, and medical guidelines for treating older adults with diabetes are limited. Broad public health programs help, but effective, targeted interventions and expanded surveillance and research and better policies are needed to address the rapidly growing diabetes burden among older adults.
Mobility and Aging: New Directions for Public Health Action
Authors: Satariano William A. , Guralnik Jack M. , Jackson Richard J. , Marottoli Richard A. , Phelan Elizabeth A. , Prohaska Thomas R.
Published: June 2012

Optimal mobility, defined as relative ease and freedom of movement in all of its forms, is central to healthy aging. Mobility is a significant consideration for research, practice, and policy in aging and public health. We examined the public health burdens of mobility disability, with a particular focus on leading public health interventions to enhance walking and driving, and the challenges and opportunities for public health action. We propose an integrated mobility agenda, which draws on the lived experience of older adults. New strategies for research, practice, and policy are needed to move beyond categorical promotion programs in walking and driving to establish a comprehensive program to enhance safe mobility in all its forms.
Obesity and Supermarket Access: Proximity or Price?
Authors: Drewnowski Adam , Aggarwal Anju , Hurvitz Philip M. , Monsivais Pablo , Moudon Anne V
Published: June 2012

Objectives. We examined whether physical proximity to supermarkets or supermarket price was more strongly associated with obesity risk.

Methods. The Seattle Obesity Study (SOS) collected and geocoded data on home addresses and food shopping destinations for a representative sample of adult residents of King County, Washington. Supermarkets were stratified into 3 price levels based on average cost of the market basket. Sociodemographic and health data were obtained from a telephone survey. Modified Poisson regression was used to test the associations between obesity and supermarket variables.

Results. Only 1 in 7 respondents reported shopping at the nearest supermarket. The risk of obesity was not associated with street network distances between home and the nearest supermarket or the supermarket that SOS participants reported as their primary food source. The type of supermarket, by price, was found to be inversely and significantly associated with obesity rates, even after adjusting for individual-level sociodemographic and lifestyle variables, and proximity measures (adjusted relative risk = 0.34; 95% confidence interval = 0.19, 0.63)

Conclusions. Improving physical access to supermarkets may be one strategy to deal with the obesity epidemic; improving economic access to healthy foods is another.
Incentives for Research Participation: Policy and Practice From Canadian Corrections
Authors: Matheson Flora I. , Forrester Pamela , Brazil Amanda , Doherty Sherri , Affleck Lindy
Published: June 2012

We explored current policies and practices on the use of incentives in research involving adult offenders under correctional supervision in prison and in the community (probation and parole) in Canada.

We contacted the correctional departments of each of the Canadian provinces and territories, as well as the federal government department responsible for offenders serving sentences of two years or more.

Findings indicated that two departments had formal policy whereas others had unwritten practices, some prohibiting their use and others allowing incentives on a case-by-case basis. Given the differences across jurisdictions, it would be valuable to examine how current incentive policies and practices are implemented to inform national best practices on incentives for offender-based research.
Developing an Integrated Strategy to Reduce Ethnic and Racial Disparities in the Delivery of Clinical Preventive Services for Older Americans
Authors: Shenson Douglas , Adams Mary , Bolen Julie , Wooten Karen , Clough Juliana , Giles Wayne H. , Anderson Lynda
Published: June 2012

Objectives. To determine the optimum strategy for increasing up-to-date (UTD) levels in older Americans, while reducing disparities between White, Black, and Hispanic adults, aged 65 years and older.

Methods. Data were analyzed from the 2008 Behavioral Risk Factor Surveillance System, quantifying the proportion of older Americans UTD with influenza and pneumococcal vaccinations, mammograms, Papanicolaou tests, and colorectal cancer screening. A comparison of projected changes in UTD levels and disparities was ascertained by numerically accounting for UTD adults lacking 1 or more clinical preventive services (CPS). Analyses were performed by gender and race/ethnicity.

Results. Expanded provision of specific vaccinations and screenings each increased UTD levels. When those needing only vaccinations were immunized, there was a projected decrease in racial/ethnic disparities in UTD levels (2.3%–12.2%). When those needing only colorectal cancer screening, mammography, or Papanicolaou test were screened, there was an increase in UTD disparities (1.6%–4.5%).

Conclusions. A primary care and public health focus on adult immunizations, in addition to other CPS, offers an effective strategy to reduce disparities while improving UTD levels.
Higher Yet Suboptimal Chlamydia Testing Rates at Community Health Centers and Outpatient Clinics Compared With Physician Offices
Authors: Eugene Jeffrey M. , Hoover Karen W. , Tao Guoyu , Kent Charlotte K.
Published: June 2012

To assess chlamydia testing in women in community health centers, we analyzed data from national surveys of ambulatory health care. Women with chlamydial symptoms were tested at 16% of visits, and 65% of symptomatic women were tested if another reproductive health care service (pelvic examination, Papanicolaou test, or urinalysis) was performed. Community health centers serve populations with high sexually transmitted disease rates and fill gaps in the provision of sexual and reproductive health care services as health departments face budget cuts that threaten support of sexually transmitted disease clinics.
Socioeconomic Inequalities in Health in Older Adults in Brazil and England
Authors: Lima-Costa M. Fernanda , De Oliveira Cesar , Macinko James , Marmot Michael
Published: June 2012

Objectives. We examined socioeconomic inequalities in health among older adults in England and Brazil.

Methods. We analyzed nationally representative samples of residents aged 50 years and older in 2008 data from the Brazilian National Household Survey (n = 75 527) and the English Longitudinal Study of Ageing (n = 9589). We estimated prevalence ratios for self-rated health, functional limitations, and reported chronic diseases, by education level and household income tertiles.

Results. Brazilians reported worse health than did English respondents. Country-specific differences were higher among the poorest, but also affected the wealthiest persons. We observed a strong inverse gradient of similar magnitude across education and household income levels for most health indicators in each country. Prevalence ratios (lowest vs highest education level) of poor self-rated health were 3.24 in Brazil and 3.50 in England; having 2 or more functional limitations, 1.81 in Brazil and 1.96 in England; and having 1 or more diseases, 1.14 in Brazil and 1.36 in England.

Conclusions. Socioeconomic inequalities in health affect both populations, despite a less pronounced absolute difference in household income and education in Brazil than in England.
Trust, Medication Adherence, and Hypertension Control in Southern African American Men
Authors: Elder Keith , Ramamonjiarivelo Zo , Wiltshire Jacqueline , Piper Crystal , Horn Wendy S. , Gilbert Keon L. , Hullett Sandral , Allison Jeroan
Published: June 2012

We examined the relationship between trust in the medical system, medication adherence, and hypertension control in Southern African American men. The sample included 235 African American men aged 18 years and older with hypertension. African American men with higher general trust in the medical system were more likely to report better medication adherence (odds ratio [OR] = 1.06), and those with higher self-efficacy were more likely to report better medication adherence and hypertension control (OR = 1.08 and OR = 1.06, respectively).
Helmet Wearing Among Users of a Public Bicycle-Sharing Program in the District of Columbia and Comparable Riders on Personal Bicycles
Authors: Kraemer John D. , Roffenbender Jason S. , Anderko Laura
Published: June 2012

Bicycle-sharing programs are increasingly popular and have the potential to increase physical activity and decrease air pollution, but anecdotal evidence suggests helmet use is lower among users of bicycle-sharing programs than cyclists on private bicycles. We conducted a cross-sectional study to assess helmet use among users of a bicycle-sharing program in Washington, DC. Helmet use was significantly lower among cyclists on shared bicycles than private bicycles, highlighting a need for targeted helmet promotion activities.
Screening, Brief Intervention, and Referral to Treatment: Public Health Training for Primary Care
Authors: Marshall Vanessa J. , McLaurin-Jones TyWanda L. , Kalu Nnenna , Kwagyan John , Scott Denise M. , Cain Gloria , Greene Wendy , Adenuga Babafemi , Taylor Robert E.
Published: June 2012

Objectives. The purpose of this study was to elucidate changes in attitudes, experiences, readiness, and confidence levels of medical residents to perform screening, brief intervention, and referral to treatment (SBIRT) and factors that moderate these changes.

Methods. A cohort of 121 medical residents received an educational intervention. Self-reported experience, readiness, attitude, and confidence toward SBIRT-related skills were measured at baseline and at follow-up. Analyses were conducted to evaluate the effects of medical specialization.

Results. The intervention significantly increased experience (P < .001), attitude (P < .05), readiness (P < .001), and confidence (P < .001). Residents were more likely to report that their involvement influenced patients’ substance use. However, experience applying SBIRT skills varied by country of birth, specialty, and baseline scores.

Conclusions. This study suggested that SBIRT training was an effective educational tool that increased residents’ sense of responsibility. However, application of skills might differ by specialization and other variables. Future studies are needed to explore and evaluate SBIRT knowledge obtained, within the context of cultural awareness and clinical skills.
The Social Determinants of Health and Pandemic H1N1 2009 Influenza Severity
Authors: Lowcock Elizabeth C. , Rosella Laura C. , Foisy Julie , McGeer Allison , Crowcroft Natasha
Published: June 2012

Objectives. We explored the effects of social determinants of health on pandemic H1N1 2009 influenza severity and the role of clinical risk factors in mediating such associations.

Methods. We used multivariate logistic regression with generalized estimating equations to examine the associations between individual- and ecological-level social determinants of health and hospitalization for pandemic H1N1 2009 illness in a case-control study in Ontario, Canada.

Results. During the first pandemic phase (April 23–July 20, 2009), hospitalization was associated with having a high school education or less and living in a neighborhood with high material or total deprivation. We also observed the association with education in the second phase (August 1–November 6, 2009). Clinical risk factors for severe pandemic H1N1 2009 illness mediated approximately 39% of the observed association.

Conclusions. The main clinical risk factors for severe pandemic H1N1 2009 illness explain only a portion of the associations observed between social determinants of health and hospitalization, suggesting that the means by which the social determinants of health affect pandemic H1N1 2009 outcomes extend beyond clinically recognized risk factors.
Suicide : Leading Cause of Death among Women in Nepal
Authors: Karki C
Published: June 2012

No abstract available.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6294 Kathmandu Univ Med J 2011;9(3):157-8
Peripheral Airway Responsiveness to Sub-maximal Exercise in Asymptomatic Cigarette Smokers.
Authors: Pokhrel B R , Chatopadhyaya S , Paudel B H
Published: June 2012

Background Cigarette smoking is one of the cardinal causes for the development of bronchial hyperresponsiveness among the smokers. Objectives This study was perspectively designed to determine the peripheral bronchial responsiveness to sub-maximal exercise challenge in the asymptomatic smokers. Methods The subjects were between age of 18-25 years without any findings of cardio-respiratory diseases. We performed the 5 min step test exercise at intensity of 80 to 90% of maximum predicted heart rate in 42 young adult male asymptomatic smokers to examine the effect of cigarette smoking on airway responsiveness. Forced expiratory spirogram was recorded before and at 0, 5, 10, 15 min after the completion of exercise. Pre- to post exercise drop in Forced Expiratory Volume in first second ? 15% was considered hyperresponsive to the challenge. Result The analysis of data (mean± SE) indicated the bronchial hyper-responsiveness in 22 (52%) smokers. The post exercise recovery time pattern showed drop in forced expiratory spirogram from the resting baseline in the responsive smokers and the maximum percentage fall in the parameters or increase in airway resistance which reflect the peripheral airway integrity such as Forced Expiratory Flow 25% (20.30 ±2.18 Vs 7.88 ±3.23, p<0.01), Forced Expiratory Flow 50% (18.46 ±4.40 Vs 1.93 ±2.78, p<0.01), Forced Expiratory Flow 75% (23.94 ±3.68 Vs 0.80 ±4.72, p<0.001) and Forced Expiratory Flow 25-75% (32.50 ±4.79 Vs 3.64 ±3.32, p<0.001) was significantly higher in the responsive than non-responsive subgroup of the smokers. Conclusion The occurrence of peripheral airway resistance is more in the responsive than non-responsive subset of smokers to the exercise challenge and hence more prone to develop obstructive airway disease in the long run. DOI: http://dx.doi.org/10.3126/kumj.v9i3.6295Kathmandu Univ Med J 2011;9(3):159-64
Age-Related Macular Degeneration in Nepal
Authors: Thapa R , Paudyal G , Shrestha M K , Gurung R , Ruit S
Published: June 2012

Background The Age–related Macular Degeneration (AMD) is a common cause of visual impairment and blindness worldwide in elderly. Objective This study aimed to explore the demographic characteristics, pattern and risk factors for AMD at a tertiary referral eye centre in Nepal. Methods This is a hospital-based prospective study, conducted at Tilganga Institute of Ophthalmology, Nepal from September 2008 to May 2009. All the consecutive cases of AMD diagnosed at the institute were included. Results A total of 141 patients (266 eyes) with AMD recruited for the study. The mean age was 69.5 years (9.1SD) with three fifth males (58.9%). Housewives and occupations like agriculture comprised of 38.3% and 42.5% respectively. Three fourth (75.6%) of the patients were illiterate. The proportion of dry and wet AMD were found in 62.4% and 37.6% respectively. Bilateral involvement was seen in 88.7% of the subjects. Three fourth (71.4%) of the AMD eyes had presenting visual acuity less than 6/18. History of smoking was found in 69.9% of patients. Hypertension was the predominant systemic problem (45.4%) followed by diabetes mellitus (12.8%). Conclusion AMD is correlated with ageing in our study as well. Dry AMD is more in age groups 45-64 years and wet AMD at 65 years and older. Bilateral involvement with one eye dry and fellow eye wet AMD is more predominant (44%). Smoking and occupations like agriculture and housewife are significant risk factors for AMD. Likewise male sex, illiteracy and hypertension are other risk factors for AMD in hospital settings.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6298 Kathmandu Univ Med J 2011;9(3):165-9
Propofol Sedation During Spinal Anaesthesia - A Dose Finding Study
Authors: Ghimire A , Bhattarai B , Rahman T R , Singh S N , Koirala S , Tripathi M
Published: June 2012

Background It is important to be able to measure and maintain a specific sedation level to compare outcomes of different levels of sedation during anesthesia and the aims include general patient comfort, freedom from specific discomfort, and some amnesia for both the block procedure and the surgical operation, in order to meet the patient’s preference and safety. In this prospective randomized clinical study, we compared the three different infusion doses of propofol. Objective To find out the appropriate infusion dose of propofol for optimal sedation without causing undue side effects in patients undergoing spinal anaesthesia. Method One hundred twenty patients ASA PS I-II were randomly allocated to three groups 1, 2 and 3 receiving propofol infusion at the rate of 25, 50 and 75 microgram/kg/min with concentration of (0.5%), (1%) and (1.5%) respectively. They were observed for sedation score, hemodynamic parameters and satisfaction level. The adverse effects like respiratory depression, nausea and vomiting score were assessed. Result Median sedation score increased in a dose dependent manner, with significantly higher scores in group 2 and 3 compared with group 1. Hemodynamic parameters were better in group 1 and 2 as judged by mephentermine requirement. The awakening time after stoppage of infusion was significantly delayed in group 3 (p < 0.001). Respiratory depression, nausea and vomiting were comparable clinically. Almost three fourth of the patients were satisfied with the techniques used. ConclusionPropofol infusion at the rate of 50mcg/kg/min for sedation in spinal anaesthesia provides optimal sedation, early awakening and excellent satisfaction level in the postoperative period.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6299 Kathmandu Univ Med J 2011;9(3):170-3
Clinical, MRI and Arthroscopic Correlation in Internal Derangement of Knee
Authors: Sharma U K , Shrestha B K , Rijal S , Bijukachhe B , Barakoti R , Banskota B , Pradhan I , Banskota A K
Published: June 2012

Background The traumatic or degenerative internal derangement of the knee requires certain investigations for the establishment of diagnosis, in addition to clinical history and a thorough physical examination. The use of arthrography and arthroscopy improves the accuracy of the diagnosis. MRI scanning of the knee joint has often been regarded as the noninvasive alternative to diagnostic arthroscopy. Objective The purpose of the study was to correlate clinical and low field MRI findings with arthroscopy in internal derangement of the knee. Methods Forty one patients with suspected internal derangement of the knee were subjected to MR examination followed by arthroscopy. Clinical criteria used were history, mode of injury, Mc Murray’s, Apley’s grinding, Thessaly’s test for meniscal injury. Drawer test was considered to be essential for clinical diagnosis of cruciate ligament injury. MRI of the knee was performed in low field open magnet (0.35T, Magnetom C, Seimens). Arthroscopy was done within two months of MR examination and was considered gold standard for the internal derangement of the knee. Results The sensitivity, specificity, diagnostic accuracy of clinical examination were 96.1%, 33.3% and 73.1% respectively for medial meniscal tear; 38.4%, 96.4% and 78.1% respectively for lateral meniscal tear. The sensitivity, specificity, diagnostic accuracy of MRI were 92.3%,100% and 95.1% for medial meniscal tear; 84.6%96.4% and 92.6% respectively for lateral meniscal tear. ConclusionClinical examination showed higher sensitivity for medial meniscal tear compared to MRI, however with low specificity and diagnostic accuracy. Low field MRI showed high sensitivity, specificity, diagnostic accuracy for meniscal and cruciate ligament injury, in addition to associated derangement like articular cartilage damage, synovial thickening.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6300 Kathmandu Univ Med J 2011;9(3):174-8
Needlestick Injuries in Dentistry
Authors: Gupta N , Tak J
Published: June 2012

Needlestick injuries and other sharps-related injuries which expose health care professionals to bloodborne pathogens continue to be an important public health concern. Dentists are at increased risk of exposure to bloodborne pathogens, including Hepatitis B, Hepatitis C, and HIV. This article presents comprehensive information on Needlestick injuries (NSI), post exposure prophylaxis, precautions and suggestions for prevention of NSI in dentistry. Dentists should remember and apply many precautions to prevent the broad spectrum of sharps and splash injuries that could occur during the delivery of dental care.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6307 Kathmandu Univ Med J 2011;9(3):208-12
Common Mental Disorders
Authors: Risal A
Published: June 2012

Common mental disorders are a group of distress states manifesting with anxiety, depressive and unexplained somatic symptoms typically encountered in community and primary care settings. Risk factors for these disorders are mainly lower socio-economic status, psychological illnesses, poor reproductive health, gender disadvantage and physical ill-health. WHO has recommended that treatment of all these disorders should be based in primary care to be more effective and accessible to all the community people. The structure of mental health care in primary care is generally understood in terms of the “pathways to care” model and it plays a major role in countries like ours where community-based mental health services do not exist. Both the psychological and pharmacological therapies are found to be equally effective for treating these disorders. Integration of mental health into primary care can be considered as the stepping stone in the way forward to tackle the barriers and problems in effective management of common mental disorders in the community. The acute shortage of mental health professionals and the relatively low levels of awareness about mental disorders make it mandatory that primary health care should remain the single largest sector for mental health care in low and middle income countries like ours.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6308 Kathmandu Univ Med J 2011;9(3):213-7
Preterm Gestation Along with Partial Hydatidiform Mole and Alive Foetus
Authors: Tamrakar S R , Chawla C D
Published: June 2012

Gestational trophoblastic disease encompasses a diverse group of lesion. If molar changes in the placenta are known along with an alive fetus then the situation is difficult to manage. We present successfully managed case of partial degeneration of placenta in molar pregnancy with an alive fetus at second stage of preterm labour.DOI: http://dx.doi.org/10.3126/kumj.v9i3.6310 Kathmandu Univ Med J 2011;9(3):222-4
Cancer treatment and survivorship statistics, 2012
Authors: Siegel Rebecca , DeSantis Carol , Virgo Katherine , Stein Kevin , Mariotto Angela , Smith Tenbroeck , Cooper Dexter , Gansler Ted , Lerro Catherine , Fedewa Stacey , Lin Chunchieh , Leach Corinne , Cannady Rachel Spillers , Cho Hyunsoon , Scoppa Steve , Hachey Mark , Kirch Rebecca , Jemal Ahmedin , Ward Elizabeth
Published: June 2012

Although there has been considerable progress in reducing cancer incidence in the United States, the number of cancer survivors continues to increase due to the aging and growth of the population and improvements in survival rates. As a result, it is increasingly important to understand the unique medical and psychosocial needs of survivors and be aware of resources that can assist patients, caregivers, and health care providers in navigating the various phases of cancer survivorship. To highlight the challenges and opportunities to serve these survivors, the American Cancer Society and the National Cancer Institute estimated the prevalence of cancer survivors on January 1, 2012 and January 1, 2022, by cancer site. Data from Surveillance, Epidemiology, and End Results (SEER) registries were used to describe median age and stage at diagnosis and survival; data from the National Cancer Data Base and the SEER‐Medicare Database were used to describe patterns of cancer treatment. An estimated 13.7 million Americans with a history of cancer were alive on January 1, 2012, and by January 1, 2022, that number will increase to nearly 18 million. The 3 most prevalent cancers among males are prostate (43%), colorectal (9%), and melanoma of the skin (7%), and those among females are breast (41%), uterine corpus (8%), and colorectal (8%). This article summarizes common cancer treatments, survival rates, and posttreatment concerns and introduces the new National Cancer Survivorship Resource Center, which has engaged more than 100 volunteer survivorship experts nationwide to develop tools for cancer survivors, caregivers, health care professionals, advocates, and policy makers. CA Cancer J Clin 2012. Published 2012 American Cancer Society.
Genetic Diversity in A Core Subset of Wild Barley Germplasm
Authors: Fu Yong-Bi , Horbach Carolee
Published: June 2012

Wild barley [Hordeum vulgare ssp. spontaneum (C. Koch) Thell.] is a part of the primary gene pool with valuable sources of beneficial genes for barley improvement. This study attempted to develop a core subset of 269 accessions representing 16 countries from the Plant Gene Resources of Canada (PGRC) collection of 3,782 accessions, and to characterize them using barley simple sequence repeat (SSR) markers. Twenty-five informative primer pairs were applied to screen all samples and 359 alleles were detected over seven barley chromosomes. Analyses of the SSR data showed the effectiveness of the stratified sampling applied in capturing country-wise SSR variation. The frequencies of polymorphic alleles ranged from 0.004 to 0.708 and averaged 0.072. More than 24% or 7% SSR variation resided among accessions of 16 countries or two regions, respectively. Accessions from Israel and Jordan were genetically most diverse, while accessions from Lebanon and Greece were most differentiated. Four and five optimal clusters of accessions were obtained using STRUCTURE and BAPS programs and partitioned 16.3% and 20.3% SSR variations, respectively. The five optimal clusters varied in size from 15 to 104 and two clusters had only country-specific accessions. A genetic separation was detected between the accessions east and west of the Zagros Mountains only at the country, not the individual, level. These SSR patterns enhance our understanding of the wild barley gene pool, and are significant for conserving wild barley germplasm and exploring new sources of useful genes for barley improvement.
An Optimization Model of Carbon Sinks in CDM Forestry Projects Based on Interval Linear Programming
Authors: Li Dufeng , Zhang Yang , Wang Xianen , Li Yu , Zhao Wenjin
Published: June 2012

This study describes the first general optimization model for complex systems with uncertain parameters and decision variables represented as intervals in CDM forestry projects. We work through a specific example of the optimization method developed for a Clean Development Mechanism (CDM) forestry project in Inner Mongolia, China. This model is designed to optimize the carbon sink capacity of the new forests, and can deal with uncertainties in the carbon sink capacity, average annual rainfall, ecological parameters, and biological characteristics of tree species. The uncertain inputs are presented in the form of intervals, as are several of the optimized output variables. Compared with the project’s originally recommended scheme, the optimized model will absorb and fix between 1,142 and 885,762 tonnes of extra carbon dioxide. Moreover, the ecological and environmental benefits of the project are also raised to various extents.
Evaluation of the Antioxidant Capacity of Synthesized Coumarins
Authors: Vianna Damiana R. , Bubols Guilherme , Meirelles Gabriela , Silva Bárbara V. , Da Rocha Alessandra , Lanznaster Maurício , Monserrat José Maria , Garcia Solange Cristina , Von Poser Gilsane , Eifler-Lima Vera Lucia
Published: June 2012

Coumarins are secondary metabolites that are widely distributed within the plant kingdom, some of which have been extensively studied for their antioxidant properties. The antioxidant activity of coumarins assayed in the present study was measured by different methods, namely the 1,1-diphenyl-2-picryl-hydrazyl (DPPH•) method, cyclic voltammetry and the antioxidant capacity against peroxyl radicals (ACAP) method. The 7,8-dihydroxy-4-methylcoumarin (LaSOM 78), 5-carboxy-7,8-dihydroxy-4-methylcoumarin (LaSOM 79), and 6,7-dihydroxycoumarin (Esculetin) compounds proved to be the most active, showing the highest capacity to deplete the DPPH radicals, the highest antioxidant capacity against peroxyl radicals, and the lowest values of potential oxidation.
The Toxicity of Amyloid ß Oligomers
Authors: Zhao Li Na , Long Hon Wai , Mu Yuguang , Chew Lock Yue
Published: June 2012

Abstract: In this review, we elucidate the mechanisms of Aβ oligomer toxicity which may contribute to Alzheimer’s disease (AD). In particular, we discuss on the interaction of Aβ oligomers with the membrane through the process of adsorption and insertion. Such interaction gives rises to phase transitions in the sub-structures of the Aβ peptide from α-helical to β-sheet structure. By means of a coarse-grained model, we exhibit the tendency of β-sheet structures to aggregate, thus providing further insights to the process of membrane induced aggregation. We show that the aggregated oligomer causes membrane invagination, which is a precursor to the formation of pore structures and ion channels. Other pathological progressions to AD due to Aβ oligomers are also covered, such as their interaction with the membrane receptors, and their direct versus indirect effects on oxidative stress and intraneuronal accumulation. We further illustrate that the molecule curcumin is a potential Aβ toxicity inhibitor as a β-sheet breaker by having a high propensity to interact with certain Aβ residues without binding to them. The comprehensive understanding gained from these current researches on the various toxicity mechanisms show promises in the provision of better therapeutics and treatment strategies in the near future.
Solution NMR Structure of Hypothetical Protein CV_2116 Encoded by a Viral Prophage Element in Chromobacterium violaceum
Authors: Yang Yunhuang , Ramelot Theresa A. , Cort John R. , Garcia Maite , Yee Adelinda , Arrowsmith Cheryl H. , Kennedy Michael A.
Published: June 2012

CV_2116 is a small hypothetical protein of 82 amino acids from the Gram-negative coccobacillus Chromobacterium violaceum. A PSI-BLAST search using the CV_2116 sequence as a query identified only one hit (E = 2e−07) corresponding to a hypothetical protein OR16_04617 from Cupriavidus basilensis OR16, which failed to provide insight into the function of CV_2116. The CV_2116 gene was cloned into the p15TvLic expression plasmid, transformed into E. coli, and 13C- and 15N-labeled NMR samples of CV_2116 were overexpressed in E. coli and purified for structure determination using NMR spectroscopy. The resulting high-quality solution NMR structure of CV_2116 revealed a novel α + β fold containing two anti-parallel β -sheets in the N-terminal two-thirds of the protein and one α-helix in the C-terminal third of the protein. CV_2116 does not belong to any known protein sequence family and a Dali search indicated that no similar structures exist in the protein data bank. Although no function of CV_2116 could be derived from either sequence or structural similarity searches, the neighboring genes of CV_2116 encode various proteins annotated as similar to bacteriophage tail assembly proteins. Interestingly, C. violaceum exhibits an extensive network of bacteriophage tail-like structures that likely result from lateral gene transfer by incorporation of viral DNA into its genome (prophages) due to bacteriophage infection. Indeed, C. violaceum has been shown to contain four prophage elements and CV_2116 resides in the fourth of these elements. Analysis of the putative operon in which CV_2116 resides indicates that CV_2116 might be a component of the bacteriophage tail-like assembly that occurs in C. violaceum.
Aroma Volatile Compounds from Two Fresh Pineapple Varieties in China
Authors: Zheng Liang-Yong , Sun Guang-Ming , Liu Yu-Ge , Lv Ling-Ling , Yang Wen-Xiu , Zhao Wei-Feng , Wei Chang-Bin
Published: June 2012

Volatile compounds from two pineapples varieties (Tainong No.4 and No.6) were isolated by headspace solid phase microextraction (HS-SPME) and identified and quantified by gas chromatography-mass spectrometry (GC/MS). In the Tainong No. 4 and No. 6 pineapples, a total of 11 and 28 volatile compounds were identified according to their retention time on capillary columns and their mass spectra, and quantified with total concentrations of 1080.44 µg·kg−1 and 380.66 µg·kg−1 in the Tainong No.4 and No. 6 pineapples, respectively. The odor active values (OAVs) of volatile compounds from pineapples were also calculated. According to the OAVs, four compounds were defined as the characteristic aroma compounds for the Tainong No. 4 pineapple, including furaneol, 3-(methylthio)propanoic acid methyl ester, 3-(methylthio)propanoic acid ethyl ester and δ-octalactone. The OAVs of five compounds including ethyl-2-methylbutyrate, methyl-2-methylbutyrate, 3-(methylthio)propanoic acid ethyl ester, ethyl hexanoate and decanal were considered to be the characteristic aroma compounds for the Tainong No. 6 pineapple.
Synthesis, Multinuclear NMR Characterization and Dynamic Property of Organic–Inorganic Hybrid Electrolyte Membrane Based on Alkoxysilane and Poly(oxyalkylene) Diamine
Authors: Saikia Diganta , Pan Yu-Chi , Kao Hsien-Ming
Published: June 2012

Organic–inorganic hybrid electrolyte membranes based on poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) bis(2-aminopropyl ether) complexed with LiClO4 via the co-condensation of tetraethoxysilane (TEOS) and 3-(triethoxysilyl)propyl isocyanate have been prepared and characterized. A variety of techniques such as differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, alternating current (AC) impedance and solid-state nuclear magnetic resonance (NMR) spectroscopy are performed to elucidate the relationship between the structural and dynamic properties of the hybrid electrolyte and the ion mobility. A VTF (Vogel-Tamman-Fulcher)-like temperature dependence of ionic conductivity is observed for all the compositions studied, implying that the diffusion of charge carriers is assisted by the segmental motions of the polymer chains. A maximum ionic conductivity value of 5.3 × 10−5 Scm−1 is obtained at 30 °C. Solid-state NMR results provide a microscopic view of the effects of salt concentrations on the dynamic behavior of the polymer chains.