bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrospun PVP/PVA Nanofiber Mat as a Novel Potential Transdermal Drug-Delivery System for Buprenorphine: A Solution Needed for Pain Management
Authors: Rahmani Fatemeh , Ziyadi Hakimeh , Baghali Mitra , Luo Hongrong , Ramakrishna Seeram
Published: March 2021

Over the past several decades, the formulation of novel nanofiber-based drug-delivery systems has been a frequent focus of scientists around the world. Aiming to introduce a novel nanofibrous transdermal drug-delivery system to treat pain, the nanofiber mats of buprenorphine-loaded poly (vinyl pyrrolidone) (Bup/PVP) and buprenorphine-loaded poly(vinyl alcohol)/poly(vinyl pyrrolidone) (Bup/PVP/PVA) were successfully fabricated by the electrospinning process for transdermal drug delivery. Similarly, PVP and PVP/PVA nanofibers were fabricated in the same conditions for comparison. The viscosity and electrical conductivity of all electrospinning solutions were measured, and nanofiber mats were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared (FT-IR) spectroscopy and contact angle analysis. The conductivity of PVP and PVP/PVA solutions showed a considerable increase by the addition of buprenorphine due to the polarity of buprenorphine. SEM images showed a smooth, fine and porous nanofibrous structure without any adhesion or knot for all of the samples. The contact angle analysis showed the increased hydrophilicity and wettability of PVP/PVA and Bup/PVP/PVA nanofibers compared to PVP and Bup/PVP nanofibers which can be attributed to the addition of PVA. Attenuated total reflectance (ATR) FT-IR results confirmed that the electrospinning process did not affect the chemical integrity of the drug. For the modification of the drug release rate, the cross-linking of nanofiber mats was carried out using glutaraldehyde. Drug release measurements using high-performance liquid chromatography (HPLC) analysis demonstrated that Bup/PVP/PVA nanofibers exhibited better physical and chemical properties compared to Bup/PVP. Furthermore, the cross-linking of nanofibers led to an increase in drug release time. Thus, the novel buprenorphine-loaded nanofibers can be efficient biomaterial patches for transdermal delivery against pain improving carrier retention and providing a controlled release of the drug.
Geochemical and Petrographical Characteristics of the Madzaringwe Formation Coal, Mudrocks and Sandstones in the Vele Colliery, Limpopo Province, South Africa: Implications for Tectonic Setting, Provenance and Paleoweathering
Authors: Denge Elelwani , Baiyegunhi Christopher
Published: March 2021

The sedimentary rocks of the Madzaringwe Formation in the Tuli Basin have been investigated using geochemical and petrographic methods to reveal their source area composition, tectonic setting, provenance and paleoweathering conditions. The petrographic studies show that the rocks consist mostly of clay minerals and quartz. The major elements geochemistry indicates that the rocks of the Madzaringwe Formation have the same source area. Based on the discriminant function plots, it can be inferred that the rocks are of quartzose sedimentary provenance, suggesting that they were derived from a cratonic interior or recycled orogen. The binary plots of TiO2 versus Zr and La/Sr against Th/Co shows that the rocks were derived from silicic or felsic igneous rocks. The tectonic setting discrimination diagrams of SiO2 against Log (K2O/Na2O), Th–Sc–Zr/10, and TiO2 versus (Fe2O3 + MgO) support passive-active continental margin settings of the provenance. The A–CN–K (Al2O3–CaO + Na2O–K2O) ternary diagram and binary plot of the index of compositional variability (ICV) against chemical index of alteration (CIA) shows that the rocks have been subjected to moderate to intensive weathering. Geochemical and petrographic characteristics of the rocks point to uplifted basement source areas predominantly composed of sedimentary rocks and/or granite-gneiss rocks. These source areas might have been from adjacent areas near the Tuli coalfield which include the Limpopo Belt (igneous and sedimentary rocks), and basement uplifted rocks of the Beit-Bridge Complex, consisting of the granite, granite-gneisses and schists.
Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 Vaccination
Authors: Kloc Malgorzata , Uosef Ahmed , Kubiak Jacek Z. , Ghobrial Rafik M.
Published: March 2021

Human placenta formation relies on the interaction between fused trophoblast cells of the embryo with uterine endometrium. The fusion between trophoblast cells, first into cytotrophoblast and then into syncytiotrophoblast, is facilitated by the fusogenic protein syncytin. Syncytin derives from an envelope glycoprotein (ENV) of retroviral origin. In exogenous retroviruses, the envelope glycoproteins coded by env genes allow fusion of the viral envelope with the host cell membrane and entry of the virus into a host cell. During mammalian evolution, the env genes have been repeatedly, and independently, captured by various mammalian species to facilitate the formation of the placenta. Such a shift in the function of a gene, or a trait, for a different purpose during evolution is called an exaptation (co-option). We discuss the structure and origin of the placenta, the fusogenic and non-fusogenic functions of syncytin, and the mechanism of cell fusion. We also comment on an alleged danger of the COVID-19 vaccine based on the presupposed similarity between syncytin and the SARS-CoV-2 spike protein.
Attitudes about Testicular Self-Examination among Polish Males
Authors: Milecki Tomasz , Majchrzak Natalia , Balcerek Adam , Rembisz Maciej , Kasperczak Michał , Antczak Andrzej
Published: March 2021

Introduction: Epidemiological data indicate an increased incidence of testicular cancer (TC), making it the most common malignant tumor in men from aged 15–45. Oncological and urological associations recommend that men with specific TC risk factors should regularly perform a testicular self-exam (TSE). The aim of the study was to discover the attitudes among Polish males regarding TSE and factors (environmental, social, educational) that affect intention to perform TSE. Methods: An original survey containing 21 questions was used to conduct a study among the Polish branch of VW (Volkswagen Poland) employees. Results: A total of 522 fully completed questionnaires were collected. The mean age of the surveyed respondents was 32 years. Information about TC and how to perform TSE was obtained by 34.4% (n = 185) of the men. It was shown that the following factors increase men’s intention to perform TSE: TC in their family member (p < 0.05; HR = 5.9; 95% CI: 1.5–23.0), GP’s(General Practitioner) recommendations (p < 0.001; HR = 6.8; 95% CI: 3.2–14.3), concern expressed by their partner (p < 0.001; HR = 3.3; 95% CI: 2.1–5.3), and social campaigns (p < 0.001; HR = 2.6; 95% CI: 1.5–4.6). Conclusions: Approximately half of young polish males do not perform TSE. Access to information on TC prevention is limited. Further action is needed to improve men’s awareness of TC and TSE.
QSAR-Based Virtual Screening of Natural Products Database for Identification of Potent Antimalarial Hits
Authors: Ferreira Letícia Tiburcio , Borba Joyce V. B. , Moreira-Filho José Teófilo , Rimoldi Aline , Andrade Carolina Horta , Costa Fabio Trindade Maranhão
Published: March 2021

With about 400,000 annual deaths worldwide, malaria remains a public health burden in tropical and subtropical areas, especially in low-income countries. Selection of drug-resistant Plasmodium strains has driven the need to explore novel antimalarial compounds with diverse modes of action. In this context, biodiversity has been widely exploited as a resourceful channel of biologically active compounds, as exemplified by antimalarial drugs such as quinine and artemisinin, derived from natural products. Thus, combining a natural product library and quantitative structure–activity relationship (QSAR)-based virtual screening, we have prioritized genuine and derivative natural compounds with potential antimalarial activity prior to in vitro testing. Experimental validation against cultured chloroquine-sensitive and multi-drug-resistant P. falciparum strains confirmed the potent and selective activity of two sesquiterpene lactones (LDT-597 and LDT-598) identified in silico. Quantitative structure–property relationship (QSPR) models predicted absorption, distribution, metabolism, and excretion (ADME) and physiologically based pharmacokinetic (PBPK) parameters for the most promising compound, showing that it presents good physiologically based pharmacokinetic properties both in rats and humans. Altogether, the in vitro parasite growth inhibition results obtained from in silico screened compounds encourage the use of virtual screening campaigns for identification of promising natural compound-based antimalarial molecules.
Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives
Authors: Lopes Raquel R. , Tomé Catarina S. , Russo Roberto , Paterna Roberta , Leandro João , Candeias Nuno R. , Gonçalves Lídia M. D. , Teixeira Miguel , Sousa Pedro M. F. , Guedes Rita C. , Vicente João B. , Gois Pedro M. P. , Leandro Paula
Published: March 2021

Phenylketonuria (PKU) is a genetic disease caused by deficient activity of human phenylalanine hydroxylase (hPAH) that, when untreated, can lead to severe psychomotor impairment. Protein misfolding is recognized as the main underlying pathogenic mechanism of PKU. Therefore, the use of stabilizers of protein structure and/or activity is an attractive therapeutic strategy for this condition. Here, we report that 3-hydroxyquinolin-2(1H)-one derivatives can act as protectors of hPAH enzyme activity. Electron paramagnetic resonance spectroscopy demonstrated that the 3-hydroxyquinolin-2(1H)-one compounds affect the coordination of the non-heme ferric center at the enzyme active-site. Moreover, surface plasmon resonance studies showed that these stabilizing compounds can be outcompeted by the natural substrate l-phenylalanine. Two of the designed compounds functionally stabilized hPAH by maintaining protein activity. This effect was observed on the recombinant purified protein and in a cellular model. Besides interacting with the catalytic iron, one of the compounds also binds to the N-terminal regulatory domain, although to a different location from the allosteric l-Phe binding site, as supported by the solution structures obtained by small-angle X-ray scattering.
Dopamine D3 Receptor Plasticity in Parkinson’s Disease and L-DOPA-Induced Dyskinesia
Authors: Lanza Kathryn , Bishop Christopher
Published: March 2021

Parkinson’s Disease (PD) is characterized by primary and secondary plasticity that occurs in response to progressive degeneration and long-term L-DOPA treatment. Some of this plasticity contributes to the detrimental side effects associated with chronic L-DOPA treatment, namely L-DOPA-induced dyskinesia (LID). The dopamine D3 receptor (D3R) has emerged as a promising target in LID management as it is upregulated in LID. This upregulation occurs primarily in the D1-receptor-bearing (D1R) cells of the striatum, which have been repeatedly implicated in LID manifestation. D3R undergoes dynamic changes both in PD and in LID, making it difficult to delineate D3R’s specific contributions, but recent genetic and pharmacologic tools have helped to clarify its role in LID. The following review will discuss these changes, recent advances to better clarify D3R in both PD and LID and potential steps for translating these findings.
Against the Resilience of High-Grade Gliomas: The Immunotherapeutic Approach (Part I)
Authors: Giotta Lucifero Alice , Luzzi Sabino
Published: March 2021

The resilience of high-grade gliomas (HGGs) against conventional chemotherapies is due to their heterogeneous genetic landscape, adaptive phenotypic changes, and immune escape mechanisms. Innovative immunotherapies have been developed to counteract the immunosuppressive capability of gliomas. Nevertheless, further research is needed to assess the efficacy of the immuno-based approach. The aim of this study is to review the newest immunotherapeutic approaches for glioma, focusing on the drug types, mechanisms of action, clinical pieces of evidence, and future challenges. A PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis)-based literature search was performed on PubMed/Medline and ClinicalTrials.gov databases using the keywords “active/adoptive immunotherapy,” “monoclonal antibodies,” “vaccine,” and “engineered T cell.”, combined with “malignant brain tumor”, “high-grade glioma.” Only articles written in English published in the last 10 years were selected, filtered based on best relevance. Active immunotherapies include systemic temozolomide, monoclonal antibodies, and vaccines. In several preclinical and clinical trials, adoptive immunotherapies, including T, natural killer, and natural killer T engineered cells, have been shown to be potential treatment options for relapsing gliomas. Systemic temozolomide is considered the backbone for newly diagnosed HGGs. Bevacizumab and rindopepimut are promising second-line treatments. Adoptive immunotherapies have been proven for relapsing tumors, but further evidence is needed.
Neurocognitive Impairment in Severe Mental Illness. Comparative study with Spanish Speaking Patients
Authors: De la Torre Gabriel , Doval Sandra , López-Sanz David , García-Sedeño Manuel , Ramallo Miguel , Bernal Macarena , González-Torre Sara
Published: March 2021

Background. Serious mental illness (SMI) represents a category of psychiatric disorders characterized by specific difficulties of personal and social functioning, derived from suffering severe and persistent mental health problems. Aims. We wanted to look into differences in cognitive performance among different SMI patients. Methods. Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) screening was applied in one sample of SMI patients (n = 149) and another of healthy comparison participants (n = 35). Within the SMI sample, three different subsamples were formed: one with 97 patients with schizophrenia, a second with 29 patients with mood disorders, and a third with 23 patients with personality disorder. We performed a comparative study within and between groups. Results. Analysis of covariance was performed. Significant differences were found for cognitive functioning including attention and memory. Conclusions. RBANS can be recommended for the detection of neurocognitive deficits in psychiatric disorders, especially in Schizophrenia.
How Downward and Upward Comparisons on Facebook Influence Grandiose and Vulnerable Narcissists’ Self-Esteem—A Priming Study
Authors: Ozimek Phillip , Bierhoff Hans-Werner , Rohmann Elke
Published: March 2021

Past research showed that social networking sites represent perfect platforms to satisfy narcissistic needs. The present study aimed to investigate how grandiose (GN) and vulnerable narcissism (VN) as well as social comparisons are associated with Facebook activity, which was measured with a self-report on three activity dimensions: Acting, Impressing, and Watching. In addition, the state self-esteem (SSE) was measured with respect to performance, social behavior, and appearance. One hundred and ten participants completed an online survey containing measures of SSE and Facebook activity and a priming procedure with three experimental conditions embedded in a social media context (upward comparison, downward comparison, and control group). Results indicated, as expected, that high VN was negatively associated with SSE on each subscale and the overall score. In addition, it was found that VN, but not GN, displayed positive associations with frequency of Facebook activities. Finally, it was proposed and confirmed that VN in interaction with the priming of downward comparisons negatively affected SSE. The conclusion drawn is that VN represents a key variable for the prediction of self-esteem as well as for the frequency of Facebook activity.
Correlation between Ground Motion Parameters and Displacement Demands of Mid-Rise RC Buildings on Soft Soils Considering Soil-Structure-Interaction
Authors: Kamal Muhammet , Inel Mehmet
Published: March 2021

This paper investigates the correlation between ground motion parameters and displacement demands of mid-rise RC frame buildings on soft soils considering the soil-structure interaction. The mid-rise RC buildings are represented by using 5, 8, 10, 13, and 15-storey frame building models with no structural irregularity. A total of 105 3D nonlinear time history analyses were carried out for 21 acceleration records and 5 different building models. The roof drift ratio (RDR) obtained as inelastic displacement demands at roof level normalized by the building height is used for demand measure, while 20 ground motion parameters were used as intensity measure. The outcomes show velocity related parameters such as Housner Intensity (HI), Root Mean Square of Velocity (Vrms), Velocity Spectrum Intensity (VSI) and Peak Ground Velocity (PGV), which reflect inelastic displacement demands of mid-rise buildings as a damage indicator on soft soil deposit reasonably well. HI is the leading parameter with the strongest correlation. However, acceleration and displacement related parameters exhibit poor correlation. This study proposed new combined multiple ground motion parameter equations to reflect the damage potential better than a single ground motion parameter. The use of combined multiple parameters can be effective in determining seismic damages by improving the scatter by at least 24% compared to the use of a single parameter.
Imaging and Management of Bladder Cancer
Authors: Wong Vincenzo K. , Ganeshan Dhakshinamoorthy , Jensen Corey T. , Devine Catherine E.
Published: March 2021

Methods: Keyword searches of Medline, PubMed, and the Cochrane Library for manuscripts published in English, and searches of references cited in selected articles to identify additional relevant papers. Abstracts sponsored by various societies including the American Urological Association (AUA), European Association of Urology (EAU), and European Society for Medical Oncology (ESMO) were also searched. Background: Bladder cancer is the sixth most common cancer in the United States, and one of the most expensive in terms of cancer care. The overwhelming majority are urothelial carcinomas, more often non-muscle invasive rather than muscle-invasive. Bladder cancer is usually diagnosed after work up for hematuria. While the workup for gross hematuria remains CT urography and cystoscopy, the workup for microscopic hematuria was recently updated in 2020 by the American Urologic Association with a more risk-based approach. Bladder cancer is confirmed and staged by transurethral resection of bladder tumor. One of the main goals in staging is determining the presence or absence of muscle invasion by tumor which has wide implications in regards to management and prognosis. CT urography is the main imaging technique in the workup of bladder cancer. There is growing interest in advanced imaging techniques such as multiparametric MRI for local staging, as well as standardized imaging and reporting system with the recently created Vesicle Imaging Reporting and Data System (VI-RADS). Therapies for bladder cancer are rapidly evolving with immune checkpoint inhibitors, particularly programmed death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) inhibitors, as well as another class of immunotherapy called an antibody-drug conjugate which consists of a cytotoxic drug conjugated to monoclonal antibodies against a specific target. Conclusion: Bladder cancer is a complex disease, and its management is evolving. Advances in therapy, understanding of the disease, and advanced imaging have ushered in a period of rapid change in the care of bladder cancer patients.
Alleviating Terminal Pediatric Cancer Pain
Authors: Moody Karen , Baig Mohammad , Carullo Veronica
Published: March 2021

Terminal cancer pain remains one of the most distressing aspects of pediatric oncology practice. Opioids are the cornerstone of cancer pain management at end-of-life and fortunately, most pain at end-of-life can be managed successfully. This article presents a practical step-by-step approach to alleviating pediatric terminal cancer pain, which can be delivered across settings.
Publisher’s Note: Continued Publication of Current Issues in Molecular Biology by MDPI
Authors: Vazquez Franck , Lin Shu-Kun
Published: March 2021

Current Issues in Molecular Biology (ISSN 1467-3045) was launched in 1999 and has published international and multidisciplinary articles on all aspects of molecular biology spanning from basic mechanisms to applications in fields primarily, but not exclusively, relevant to microbiology and virology [...]
Where to Go or Where Not to Go—A Method for Advising Communities during Extreme Temperatures
Authors: Madureira Helena , Monteiro Ana , Cruz Sara
Published: March 2021

Climate change is producing more extremes and increasing the number and magnitude of risks that impact people’s lives, so identifying and understanding local climate risks is a long but essential process for defining adaptation strategies. The availability of technologies to sensitize and educate people about risks, and to assist people with becoming active observers and monitors of climatic elements has helped to promote permanent surveillance and proactive attitudes towards climatic phenomena that lead to undesirable risks. This paper proposes a methodological approach to guide citizens moving around the city when extreme temperatures occur, minimizing climatic risks and negative health comes, using a very simple method based on Landsat 8 temperature data images at a subsection spatial scale level. The results obtained indicate the places of higher extreme temperatures risks, as well as some of the potential places that people can use to protect themselves. This work demonstrates the value of mapping climatic factors at a local scale and deliver tailored and accurate maps with the places suitable for alleviating bioclimatic stresses and the places that should be avoided.
Solution Cocrystallization: A Scalable Approach for Cocrystal Production
Authors: Pawar Nitin , Saha Anindita , Nandan Neelesh , Parambil Jose
Published: March 2021

With an increasing interest in cocrystals due to various advantages, demand for large-scale cocrystallization techniques is rising. Solution cocrystallization is a solvent-based approach that utilizes several single-component crystallization concepts as well as equipment for generating cocrystals. Solution-based techniques can produce cocrystals with reasonable control on purity, size distribution, morphology, and polymorphic form. Many of them also offer a scalable solution for the industrial production of cocrystals. However, the complexity of the thermodynamic landscape and the kinetics of cocrystallization offers fresh challenges which are not encountered in single component crystallization. This review focuses on the recent developments in different solution cocrystallization techniques for the production of pharmaceutically relevant cocrystals. The review consists of two sections. The first section describes the various solution cocrystallization methods, highlighting their benefits and limitations. The second section emphasizes the challenges in developing these techniques to an industrial scale and identifies the major thrust areas where further research is required.
Coordination Ability of 10-EtC(NHPr)=HN-7,8-C2B9H11 in the Reactions with Nickel(II) Phosphine Complexes
Authors: Stogniy Marina Yu. , Erokhina Svetlana A. , Suponitsky Kyrill Yu. , Sivaev Igor B. , Bregadze Vladimir I.
Published: March 2021

The complexation reactions of nido-carboranyl amidine 10-PrNHC(Et)=HN-7,8-C2B9H11 with different nickel(II) phosphine complexes such as [(PR2R’)2NiCl2] (R = R’ = Ph, Bu; R = Me, R’ = Ph) were investigated. As a result, a series of novel half-sandwich nickel(II) π,σ-complexes [3-R’R2P-3-(8-PrN=C(Et)NH)-closo-3,1,2-NiC2B9H10] with the coordination of the carborane and amidine components was prepared. The acidification of obtained complexes with HCl led to the breaking of the Ni-N bond with formation of nickel(II) π-complexes [3-Cl-3-R’R2P-8-PrNH=C(Et)NH-closo-3,1,2-NiC2B9H10]. The crystal molecular structure of [3-Ph3P-3-(8-PrN=C(Et)NH)-closo-3,1,2-NiC2B9H10] was determined by single crystal X-ray diffraction.
Microsatellite Instability in Colorectal Cancer Liquid Biopsy—Current Updates on Its Potential in Non-Invasive Detection, Prognosis and as a Predictive Marker
Authors: Tieng Francis Yew Fu , Abu Nadiah , Lee Learn-Han , Ab Mutalib Nurul-Syakima
Published: March 2021

Colorectal cancer (CRC) is the third most commonly-diagnosed cancer in the world and ranked second for cancer-related mortality in humans. Microsatellite instability (MSI) is an indicator for Lynch syndrome (LS), an inherited cancer predisposition, and a prognostic marker which predicts the response to immunotherapy. A recent trend in immunotherapy has transformed cancer treatment to provide medical alternatives that have not existed before. It is believed that MSI-high (MSI-H) CRC patients would benefit from immunotherapy due to their increased immune infiltration and higher neo-antigenic loads. MSI testing such as immunohistochemistry (IHC) and PCR MSI assay has historically been a tissue-based procedure that involves the testing of adequate tissue with a high concentration of cancer cells, in addition to the requirement for paired normal tissues. The invasive nature and specific prerequisite of such tests might hinder its application when surgery is not an option or when the tissues are insufficient. The application of next-generation sequencing, which is highly sensitive, in combination with liquid biopsy, therefore, presents an interesting possibility worth exploring. This review aimed to discuss the current body of evidence supporting the potential of liquid biopsy as a tool for MSI testing in CRC.
Desmoplastic Small Round Cell Tumor with “Pure” Spindle Cell Morphology and Novel EWS-WT1 Fusion Transcript: Expanding the Morphological and Molecular Spectrum of This Rare Entity
Authors: Magro Gaetano , Broggi Giuseppe , Zin Angelica , Di Benedetto Vincenzo , Meli Mariaclaudia , Di Cataldo Andrea , Alaggio Rita , Salvatorelli Lucia
Published: March 2021

Background: Desmoplastic small round cell tumor (DSRCT) is a rare pediatric soft tissue neoplasm composed of small round tumor cells with prominent stromal desmoplasia, polyphenotypic differentiation and EWSR1-WT1 gene fusion. We, herein, present a unique case of DSRCT, exhibiting a pure spindle cell morphology, absence of desmoplastic stroma and showing a novel EWS-WT1 fusion transcript. Methods: A 12-year-old boy presented multiple intra-abdominal, confluent and mass-forming nodules that affected the entire abdominal and pelvic cavities. Results: Histologically, the nodules were composed of spindle cells with scant cytoplasm and oval nuclei arranged into short, intersecting fascicles and set in a scant, non-desmoplastic, stroma. Immunohistochemically, neoplastic cells were stained with vimentin, desmin, WT-1 (C-terminus antibodies) and EMA. Reverse-transcriptase polymerase chain reaction (RT-PCR) analysis showed the presence of an unusual chimeric transcript, composed of an in-frame junction of exon 9 of EWS to exon 7 of WT1, confirming the histological diagnosis of DSRCT. Conclusions: The present case contributes to widen the morphological spectrum of this entity; notably, the additional presence of a novel chimeric fusion transcript contributes to making the present case even more unique. Whether the detection of the above-mentioned fusion transcripts could explain the unusual morphology of the tumor remains to be established.
Diagnostic Role of 18F-PSMA-1007 PET/CT in Prostate Cancer Staging: A Systematic Review
Authors: Awenat Salam , Piccardo Arnoldo , Carvoeiras Patricia , Signore Giovanni , Giovanella Luca , Prior John O. , Treglia Giorgio
Published: March 2021

Background: The use of prostate-specific membrane antigen (PSMA)-targeted agents for staging prostate cancer (PCa) patients using positron emission tomography/computed tomography (PET/CT) is increasing worldwide. We performed a systematic review on the role of 18F-PSMA-1007 PET/CT in PCa staging to provide evidence-based data in this setting. Methods: A comprehensive computer literature search of PubMed/MEDLINE and Cochrane Library databases for studies using 18F-PSMA-1007 PET/CT in PCa staging was performed until 31 December 2020. Eligible articles were selected and relevant information was extracted from the original articles by two authors independently. Results: Eight articles (369 patients) evaluating the role of 18F-PSMA-1007 PET/CT in PCa staging were selected. These studies were quite heterogeneous, but, overall, they demonstrated a good diagnostic accuracy of 18F-PSMA-1007 PET/CT in detecting PCa lesions at staging. Overall, higher primary PCa aggressiveness was associated with higher 18F-PSMA-1007 uptake. When compared with other radiological and scintigraphic imaging methods, 18F-PSMA-1007 PET/CT had superior sensitivity in detecting metastatic disease and the highest inter-reader agreement. 18F-PSMA-1007 PET/CT showed similar results in terms of diagnostic accuracy for PCa staging compared with PET/CT with other PSMA-targeted tracers. Dual imaging with multi-parametric magnetic resonance imaging and 18F-PSMA-1007 PET/CT may improve staging of primary PCa. Notably, 18F-PSMA-1007-PET/CT may detect metastatic disease in a significant number of patients with negative standard imaging. Conclusions: 18F-PSMA-1007 PET/CT demonstrated a good accuracy in PCa staging, with similar results compared with other PSMA-targeted radiopharmaceuticals. This method could substitute bone scintigraphy and conventional abdominal imaging for PCa staging. Prospective multicentric studies are needed to confirm these findings.
Radioiodine in Differentiated Thyroid Carcinoma: Do We Need Diagnostic Pre-Ablation Iodine-123 Scintigraphy to Optimize Treatment?
Authors: de Koster Elizabeth J. , Sulaiman Taban , Hamming Jaap F. , Schepers Abbey , Snel Marieke , van Velden Floris H. P. , de Geus-Oei Lioe-Fee , Vriens Dennis
Published: March 2021

Changing insights regarding radioiodine (I-131) administration in differentiated thyroid carcinoma (DTC) stir up discussions on the utility of pre-ablation diagnostic scintigraphy (DxWBS). Our retrospective study qualitatively and semi-quantitatively assessed posttherapy I-131 whole-body scintigraphy (TxWBS) data for thyroid remnant size and metastasis. Findings were associated with initial treatment success after nine months, as well as clinical, histopathological, and surgical parameters. Possible management changes were addressed. A thyroid remnant was reported in 89 of 97 (92%) patients, suspicion of lymph node metastasis in 26 (27%) and distant metastasis in 6 (6%). Surgery with oncological intent and surgery by two dedicated thyroid surgeons were independently associated with a smaller remnant. Surgery at a community hospital, aggressive tumor histopathology, histopathological lymph node metastasis (pN1) and suspicion of new lymph node metastasis on TxWBS were independently associated with an unsuccessful treatment. Thyroid remnant size was unrelated to treatment success. All 13 pN1 patients with suspected in situ lymph node metastases on TxWBS had an unsuccessful treatment, opposite 19/31 (61%) pN1 patients without (p = 0.009). Pre-ablative knowledge of these TxWBS findings had likely influenced management in 48 (50%) patients. Additional pre-ablative diagnostics could optimize patient-tailored I-131 administration. DxWBS should be considered, especially in patients with pN1 stage or suspected in situ lymph node metastasis. Dependent on local surgical expertise, DxWBS is not recommended to evaluate thyroid remnant size.
FastUAV-NET: A Multi-UAV Detection Algorithm for Embedded Platforms
Authors: Yavariabdi Amir , Kusetogullari Huseyin , Celik Turgay , Cicek Hasan
Published: March 2021

In this paper, a real-time deep learning-based framework for detecting and tracking Unmanned Aerial Vehicles (UAVs) in video streams captured by a fixed-wing UAV is proposed. The proposed framework consists of two steps, namely intra-frame multi-UAV detection and the inter-frame multi-UAV tracking. In the detection step, a new multi-scale UAV detection Convolutional Neural Network (CNN) architecture based on a shallow version of You Only Look Once version 3 (YOLOv3-tiny) widened by Inception blocks is designed to extract local and global features from input video streams. Here, the widened multi-UAV detection network architecture is termed as FastUAV-NET and aims to improve UAV detection accuracy while preserving computing time of one-step deep detection algorithms in the context of UAV-UAV tracking. To detect UAVs, the FastUAV-NET architecture uses five inception units and adopts a feature pyramid network to detect UAVs. To obtain a high frame rate, the proposed method is applied to every nth frame and then the detected UAVs are tracked in intermediate frames using scalable Kernel Correlation Filter algorithm. The results on the generated UAV-UAV dataset illustrate that the proposed framework obtains 0.7916 average precision with 29 FPS performance on Jetson-TX2. The results imply that the widening of CNN network is a much more effective way than increasing the depth of CNN and leading to a good trade-off between accurate detection and real-time performance. The FastUAV-NET model will be publicly available to the research community to further advance multi-UAV-UAV detection algorithms.
Perylene Based Solution Processed Single Layer WOLED with Adjustable CCT and CRI
Authors: Bozkus Volkan , Aksoy Erkan , Varlikli Canan
Published: March 2021

In solution processed single layer white organic light emitting diode (WOLED) applications, the choice of host matrix and optimization of dopant levels represent two crucial parameters to consider. In this work, poly(N-vinylcarbazole) (PVK): 2-(4-Biphenylyl)-5-phenyl-1,3,4-oxadiazole (PBD) and PVK:1,3-bis[(4-tert-butylphenyl)-1,3,4-oxadiazolyl] phenylene (OXD-7) matrices are used as hosts for perylene based devices. PVK:PBD presented better compatibility and lower turn-on voltages compared to PVK:OXD-7. Benefiting from the exciplex emission observed at 630 nm, a color rendering index (CRI) value of 90 is reached with the device containing PVK:PBD as the host and 0.1 wt.% of an orange emitting perylene derivative, i.e., PDI. Introduction of the perylene based green emitter, i.e., PTE, in this emitting layer not only caused a fading in the exciplex emission, but also resulted in disappearance of the electroplex peak at 535 nm, which is detected between PVK:PBD and PTE in bare PTE containing devices. Full visible range coverage is achieved by optimizing the PDI:PTE ratio. WOLED containing PVK:PBD:0.06 wt.% PDI:0.03 wt.% PTE presented high CRI (≥95) and adjustable correlated color temperatures (CCT, 3800 K-5100 K).
On-Axis Resolution of a Circular Aperture
Authors: Maisto Maria Antonia
Published: March 2021

In this paper, the problem to estimate the on-axis resolution in creating a desired field profile by radiation of an aperture A is addressed. The latter applies in both diffractive optics and antenna synthesis. This is because the ‘aperture theory’, A can schematize a source, for example, an antenna or a lens illuminated by an incident field radiating a significant field only on the same aperture. The analysis refers to a customary axicon geometry consisting of a circle aperture transverse to the observation domain. The aim was to find a resolution formula allowing to highlight the impact of aperture geometrical parameters for configurations that are below the Fresnel approximation. The results show that the aperture cannot approximate the target field with the same level of accuracy along with the observation domain. In particular, near the aperture, smaller details can be retrieved and as the distance increases this ability degrades.
Multi-Level Switching of Al-Doped HfO2 RRAM with a Single Voltage Amplitude Set Pulse
Authors: Lin Jinfu , Wang Shulong , Liu Hongxia
Published: March 2021

In this paper, the resistive switching characteristics in a Ti/HfO2: Al/Pt sandwiched structure are investigated for gradual conductance tuning inherent functions. The variation in conductance of the device under different amplitudes and voltage pulse widths is studied. At the same time, it was found that the variation in switching parameters in resistive random-access memory (RRAM) under impulse response is impacted by the initial conductance states. The device was brought to a preset resistance value range by energizing a single voltage amplitude pulse with a different number of periodicities. This is an efficient and simple programming algorithm to simulate the strength change observed in biological synapses. It exhibited an on/off of about 100, an endurance of over 500 cycles, and a lifetime (at 85 °C) of around 105 s. This multi-level switching two-terminal device can be used for neuromorphic applications to simulate the gradual potentiation (increasing conductance) and inhibition (decreasing conductance) in an artificial synapse.
Performance Assessment of Japanese Electricity and Gas Companies during 2002–2018: Three DEA Approaches
Authors: Sueyoshi Toshiyuki , Goto Mika
Published: March 2021

This study has compared Japan’s major electricity and gas companies in terms of their corporate performance measures from 2002 to 2018 using three types of Data Envelopment Analysis (DEA) approaches. We develop a new type of efficiency measures and indexes for DEA and then compare the performance of major electric power companies and city gas companies by examining a recent data set that include years after the Fukushima Daiichi Nuclear Power Plant accident. The data set incorporates the number of patents as an output that represents companies’ capability for technology innovation to investigate intertemporal changes of efficiency through index measures. The results provide us with two important findings. First, the electricity industry has experienced long-term difficulty due to the nuclear plant disaster; while the gas industry experienced less difficulty from the accident. Second, both industries have been gradually improving performance measures in recent years. However, the gas industry has outperformed the electricity industry. From the results, this study discusses important policy implications for Japan’s energy utility industry and academic research on the industry.
Flexibility Management with Virtual Batteries of Thermostatically Controlled Loads: Real-Time Control System and Potential in Spain
Authors: Martín-Crespo Alejandro , Saludes-Rodil Sergio , Baeyens Enrique
Published: March 2021

Load flexibility management is a promising approach to face the problem of balancing generation and demand in electrical grids. This problem is becoming increasingly difficult due to the variability of renewable energies. Thermostatically-controlled loads can be aggregated and managed by a virtual battery, and they provide a cost-effective and efficient alternative to physical storage systems to mitigate the inherent variability of renewable energy sources. However virtual batteries require that an accurate control system is capable of tracking frequency regulation signals with minimal error. A real-time control system allowing virtual batteries to accurately track frequency or power signals is developed. The performance of this controller is validated for a virtual battery composed of 1000 thermostatically-controlled loads. Using virtual batteries equipped with the developed controller, a study focused on residential thermostatically-controlled loads in Spain is performed. The results of the study quantify the potential of this technology in a country with different climate areas and provides insight about the feasibility of virtual batteries as enablers of electrical systems with high levels of penetration of renewable energy sources.
Comparing Bioeconomy Potential at National vs. Regional Level Employing Input-Output Modeling
Authors: Jurga Piotr , Loizou Efstratios , Rozakis Stelios
Published: March 2021

The support of economic sectors that exploit natural bio-based resources in a particular region is an opportunity to benefit from local potentials in terms of sustainability, employment, output, and household income. Hence a relevant question emerges, namely, how can bioeconomy sectors be adequately supported? Within this context, another issue is whether the bioeconomy development strategy at a national level should be the same as that at a regional level. To address these issues, in the current study a comparison was made between the bioeconomy sectors at the country level based on the case study of Poland and one of the poorest regions in the European Union—the Lubelskie Region. A regional input–output model was built for the regional economy and compared with the national model. The bioeconomy-oriented regional input–output table was built by applying a hybrid regionalization method, combining non-survey techniques and a questionnaire survey that was carried out in companies of mixed bio-based sectors. Sectoral linkages, such as multipliers and elasticities, indicate notable differences among the bio-based sectors’ potentials of the regional and national economies. Therefore, a bioeconomy development strategy should be seen to differ at national and regional levels.
Extended SINDICOMP: Characterizing MV Voltage Transformers with Sine Waves
Authors: Crotti Gabriella , D’Avanzo Giovanni , Giordano Domenico , Letizia Palma Sara , Luiso Mario
Published: March 2021

The paper presents a method for the frequency characterization of voltage transformers (VTs) for medium voltage (MV) grids which involves only sine waves. It is called extended SINDICOMP, since it is an extended version of the previously developed technique SINDICOMP. It requires, in the first step, an evaluation and a compensation of the non-linearity introduced by the VT when it is supplied with a 50 Hz sinusoidal input at rated value. Then, the VT is characterized with a low voltage sinusoidal frequency sweep from the second harmonic frequency up to the first resonance frequency. Some rules to build the approximated frequency response, starting from these two sets of data, are given in the paper. The proposed approach is applied to three commercial MV VTs. Significant improvement of the VT performance is obtained, compared to the use of a frequency response obtained from the low voltage characterization.
Resuscitation of Pulsed Electric Field-Treated Staphylococcus aureus and Pseudomonas putida in a Rich Nutrient Medium
Authors: Emanuel Efrat , Dubrovin Irina , Pogreb Roman , Pinhasi Gad A. , Cahan Rivka
Published: March 2021

Pulsed electric fields (PEFs) technology was reported to be useful as a disinfection method in the liquid food industry. This technology may lead to membrane permeabilization and bacterial death. However, resuscitation of viable but non-culturable cells and sublethally injured microorganisms in food was reported to be associated with foodborne outbreaks. The main aim of this study was to investigate the possible recovery of injured PEF-treated bacteria. The PEF treatment of Staphylococcus aureus and Pseudomonas putida led to a reduction of 3.2 log10 and 4.8 log10, respectively. After 5 h, no colony forming units (CFUs) were observed when the bacteria were suspended in phosphate buffer saline (PBS); and for 24 h, no recovery was observed. The PEF-treated S. aureus in brain-heart infusion (BHI) medium were maintained at 1.84 × 104 CFU mL−1 for about 1.5 h. While P. putida decreased to zero CFU mL−1 by the 4th hour. However, after that, both bacteria recovered and began to multiply. Flow cytometry analysis showed that PEF treatment led to significant membrane permeabilization. Mass spectrometry analysis of PEF-treated P. putida which were suspended in BHI revealed over-expression of 22 proteins, where 55% were related to stress conditions. Understanding the recovery conditions of PEF-treated bacteria is particularly important in food industry pasteurization. To our knowledge, this is the first comprehensive study describing the recovery of injured PEF-treated S. aureus and P. putida bacteria.
A Generalization of a Fractional Variational Problem with Dependence on the Boundaries and a Real Parameter
Authors: Almeida Ricardo , Martins Natália
Published: March 2021

In this paper, we present a new fractional variational problem where the Lagrangian depends not only on the independent variable, an unknown function and its left- and right-sided Caputo fractional derivatives with respect to another function, but also on the endpoint conditions and a free parameter. The main results of this paper are necessary and sufficient optimality conditions for variational problems with or without isoperimetric and holonomic restrictions. Our results not only provide a generalization to previous results but also give new contributions in fractional variational calculus. Finally, we present some examples to illustrate our results.
Norm Localization and Contestation: The Politics of Foster Children in Turkey
Authors: Ellis Burcu Akan
Published: March 2021

International norms do not diffuse linearly; they are localized, adapted and contested at every turn. Foster care systems have been enthusiastically promoted by international organizations to serve the best interests of children. This study explores the recent adaptation of foster care (Koruyucu Aile) in Turkey. This elite-driven norm change was institutionalized through comprehensive legislation, economic incentives and national campaigns, situated in the “politics of responsibility” arising from moral duty and national and religious ethics. These efforts faced early resistance, leading to slow cultivation of foster families, while over time, the foster system found unlikely allies among urban middle-class women. Using Zimmermann’s typologies of reinterpretation of norms through an analysis of narratives about foster parenting in 50 local and national TV productions, this article shows how the foster family system has evolved as a panacea for women’s empowerment in contemporary Turkish society. In parallel, Turkey has embarked on an intense criticism of the care of ethnic Turkish children in European foster care systems. However, this creative utilization of the foster system has come at the cost of the rights of biological parents and a permanency that has decoupled the Turkish foster care system from its counterparts around the world.