bluuebunny/crossref_metadata_2025 huggingface dataset:
Race, Color, and the Application of Pool Theory
Authors: Adibifar Karam
Published: June 2023

In today’s complex society, we encounter various societal issues. However, race as an attribute and as a major social form tremendously affects many aspects of individuals’ lives, as well as society as a whole. It continues to shape social, political, and economic hierarchies. Many sociological theories that have focused on race and racism, but few have focused on an in-depth understanding of subtle racism and its socio-historical constructs. The purpose of this paper is to discuss and explore race, color, and racism, particularly the subjective form of racism, utilizing the Pool Theory.Pool theory, based on acquired idea from the billiard game, asserts that racism is formed through people’s implicit attitudes, feelings, and behaviors. It emphasizes that race, like many other social concepts, is socially and culturally created by the dominant groups for labeling others to suit their own imagination and goals. Based on generalizations, the theory accentuates that race is subjective and implicit, and that skin color is highly valued in society. According to this theory, those who possess favorite colors are more likely to be seen as superior, influential, valued, and successful in constructing concepts that becomes social reality. The choice of colors and the position of the billiard balls could be the consequence of implicit feelings and biased beliefs about others. Power differentiation, disparity, and colorism are evident in this game. Pool theory refutes color blindness, which is the belief that racism is no longer an issue in American society. The main objective of this study is to encourage future research in theory building, emphasizing the implicit aspects of racism. Additionally, this study can serve as an avenue for literature review, particularly in relation to race and racism.
Effectiveness of perioperative anticoagulation interruption without heparin bridging on thromboembolic events in patients with atrial fibrillation undergoing elective invasive procedures: a systematic review protocol
Authors: Kaur Jaspreet , Thomas Liza , Bhat Aditya , Barker Timothy Hugh
Published: June 2023

Objective:

This review will determine whether withholding heparin bridging is superior to bridging in patients with atrial fibrillation requiring temporary interruption of anticoagulation therapy in the perioperative period of an elective invasive procedure.

Introduction:

Atrial fibrillation is the most commonly diagnosed clinical arrhythmia. It is an important cause of cardioembolic events, requiring the use of oral anticoagulation in most patients. It is unclear whether heparin bridging during temporary interruption of anticoagulants has superior outcomes compared with no bridging in the perioperative setting.

Inclusion criteria:

This review will consider studies that compare adults aged 18 years or older; diagnosed with atrial fibrillation; undergoing elective invasive procedures; and who have had oral anticoagulants temporarily withheld with heparin bridging with patients without heparin bridging. Participants will be excluded if they had an alternative reason for anticoagulation or were admitted for emergency surgery. Outcomes will include arterial or venous thromboembolism (including stroke, transient ischemic attack, systemic embolism), major bleeding events, non-major bleeding events, length of hospital stay, and all-cause mortality.

Methods:

The review will follow the JBI methodology for systematic reviews of effectiveness. Databases including MEDLINE, Embase, CINAHL, and CENTRAL will be searched for randomized and non-randomized trials from inception until the present. Two independent reviewers will screen citations by title and abstract, and again at full text. Risk of bias will be assessed using the JBI critical appraisal instrument, and data will be extracted using a modified extraction tool. Results will be synthesized using a random effects meta-analysis and presented in a forest plot. Heterogeneity will be tested for using the standard χ2 and I
2 tests. Overall certainty of evidence will be evaluated using the GRADE approach.

Review registration:

PROSPERO CRD42022348538
An Experimental and Numerical Investigation of Cardiac Tissue-Patch Interrelation
Authors: Basara Gozde , Bahcecioglu Gokhan , Ren Xiang , Zorlutuna Pinar
Published: June 2023

Tissue engineered cardiac patches have great potential as a regenerative therapy for myocardial infarction. Yet, the mutual interaction of cardiac patches with healthy tissue has not been completely understood. Here, we investigated the impact of acellular and cellular patches on a beating two-dimensional (2D) cardiac cell layer, and the effect of the beating of this layer on the cells encapsulated in the patch. We cultured human-induced pluripotent stem cell-derived cardiomyocytes (iCMs) on a coverslip and placed gelatin methacryloyl hydrogel alone or with encapsulated iCMs to create acellular and cellular patches, respectively. When the acellular patch was placed on the cardiac cell layer, the beating characteristics and Ca+2 handling properties reduced, whereas placing the cellular patch restored these characteristics. To better understand the effects of the cyclic contraction and relaxation induced by the beating cardiac cell layer on the patch placed on top of it, a simulation model was developed, and the calculated strain values were in agreement with the values measured experimentally. Moreover, this dynamic culture induced by the beating 2D iCM layer on the iCMs encapsulated in the cellular patch improved their beating velocity and frequency. Additionally, the encapsulated iCMs were observed to be coupled with the underlying beating 2D iCM layer. Overall, this study provides a detailed investigation on the mutual relationship of acellular/cellular patches with the beating 2D iCM layer, understanding of which would be valuable for developing more advanced cardiac patches.
Evaluation of Turbine Tip Clearance With Performance Degradation Using Multilayer Perceptron
Authors: Yang Yue , Mao Junkui , Guo Naxian , Chen Pingting , Wang Feilong
Published: June 2023

This paper developed a process for turbine tip clearance prediction and control considering performance degradation to address the contradiction between computational efficiency and computational accuracy. The developed process consists of an offline high-accuracy database establishment for tip clearance with performance degradation and an online fast tip clearance prediction and control using machine learning. For the former, the steady-state tip clearance is obtained by the calculations for the two-dimensional axisymmetric casing and disk deformations using the finite element method and the one-dimensional blade deformation using the engineering calculation method. The effects of performance degradation, including blade creep and turbine inlet temperature degradation are introduced to update the boundary conditions in gas path and initial clearance. For the latter, the multilayer perceptron is used to realize the fast tip clearance prediction. Considering the independence of component deformations, the tip clearance prediction is achieved by the component deformation predictions, which also reduces the dimension of input parameters for each prediction model and improves the prediction accuracy. Combining the above two parts, the tip clearance with performance degradation can be obtained within 0.00025 s/time, and the maximum absolute error is only 0.012 mm. In addition, with the help of the process, the optimized tip clearance control strategy can be obtained for the performance degradation states, which restores the tip clearance with a 17.66% increment to the initial state without performance degradation. This paper will provide a reference for the tip clearance prediction and control with small computation and high accuracy.
Section VIII, Division 3—Alternative Rules for Construction of High-Pressure Vessels
Authors: Sims J. Robert , Cooch S. Michael
Published: June 2023

This chapter provides a commentary on the ASME Boiler and Pressure Vessel Code, Section VIII, Division 3, 2019 Edition. It is intended to be used as a companion to Division 3 by Manufacturers and Users of high-pressure vessels, and will also provide guidance to Inspectors, materials suppliers, and others. The material is generally presented in the same order in which it appears in the Code. Comments are not given about each paragraph, but paragraph numbers are referenced as appropriate. The comments apply to the 2019 Edition.

History

The original author of this chapter was J. Robert Sims Jr. who updated the chapter for the second, third and fourth editions and was joined by Charles Becht V for the fifth edition. For this revision, Mr. Sims has been joined by S. Michael Cooch.
Section XI Flaw Acceptance Criteria and Evaluation Using Code Procedures
Authors: Cipolla Russell C.
Published: June 2023

For the sixth edition, this chapter has been updated with revised Code requirements and Code Cases from the 2017 Code and 2019 Code Editions. The important areas of revised requirements and procedures include flaw proximity rules in IWA-3300, change in the yield strength limits from 50 ksi to 90 ksi for selected grades of SA-508 and SA-533, addition of stress intensity factor equations for circumferential OD surface flaws in Appendix A, A-3000, revised procedures for pipe flaw evaluation in Appendix C, C-4000 and C-5300, and an updated glossary terminology/definitions. Several new and revised Code Cases are also discussed to include N-513-5 (temporary acceptance of flaws in moderate energy piping systems), N-705-1 (temporary acceptance of flaws in moderate energy vessels and tanks), N-806-1 (evaluation of wall loss in buried pipe), N-848-1 (proximity rules for quasi-laminar flaws), N-869 (extension of N-513 to higher pressures for Class 2 and 3 piping systems), N-877 (characterization of multiple subsurface radially oriented planar flaws), N-889 (new reference curves for irradiated-assisted stress corrosion cracking growth for austenitic stainless steels), N-899 (weld residual stress reference curves for dissimilar metal welds), and N-890 (materials exempted from Appendix G, G-2110(b) requirements). It is important to note that additional proposal changes are being developed by the committees, some of which are discussed in 30.11.

History

Arthur F. Deardorff was the original author of this chapter that was updated by Mr. Deardorff in the second edition. For the third through fifth editions, Russell C. Cipolla revised the entire chapter although retaining certain portions of the previous text, equations, tables, and figures. For the current online edition, Mr. Cipolla has updated using 2017 and 2019 Editions, and additional information as appropriate.
IWE and IWL
Authors: Ferlisi Mark J. , Walden Scott , Staffiera Jim
Published: June 2023

This chapter addresses ASME Code Section XI, Subsections IWE and IWL, for nuclear power plant containments. Subsection IWE provides requirements for preservice and inservice examination/inspection, repair/replacement (R/R) activities, and testing of Class MC (metal containment) pressure-retaining components and their integral attachments and R/R activities. It also provides requirements for testing of Class CC (concrete containment) pressure-retaining components and their integral attachments for boiling water reactors (BWRs) and pressurized water reactors (PWRs). Similarly, Subsection IWL provides requirements for preservice and inservice examination/inspection, R/R activities, and testing of the reinforced concrete and post-tensioning systems of Class CC components for BWRs and PWRs. Together with Subsection IWA, a comprehensive basis is provided for ensuring the continued structural and leak-tight integrity of containments in nuclear power plants. The chapter includes a brief history of the development of ASME Code requirements, the latest information on the U.S. Nuclear Regulatory Commission regulatory review and incorporation of recent ASME Code Editions and Addenda, and current listings of U.S. ‘construction-complete’ commercial nuclear power plants and their containment types and operating status. A summary of recent nuclear industry developments in advanced plant designs and a discussion of the as-yet-unrealized ‘U.S. nuclear renaissance’ are also presented, along with information on the global demand for energy and the current status of commercial nuclear power around the world. Lastly, the current Subsection IWE and IWL Commentaries, as approved and maintained by the ASME Working Group on Containment, are included.

History

The late Robert F. Sammataro authored this chapter for the 1st edition. Jim Staffiera also authored previous revisions of this chapter. The current edition was updated by Mark J. Ferlisi and Scott Walden
Fatigue Crack Growth, Fatigue, and Stress Corrosion Crack Growth: Section XI Evaluation
Authors: Bamford Warren H.
Published: June 2023

Fatigue has often been described as the most common cause of failure in engineering structures, and designers of pressure vessels and piping have incorporated fatigue considerations into design requirements since the first edition of Section III in 1963. The development of this technology and its application in Section III are discussed in Chapter 39 of the third edition of this publication. Its application in Section XI is discussed in Section 32.3 of this chapter.

With the advancement of the state of the art, the ability to recognize how the growth and size of a crack can lead to failure has been enhanced. This technology has been a key aspect of the Section XI flaw evaluation procedures since the 1974 edition was published and will be discussed thoroughly herein.

Further advancements in the state-of-the-art in fracture evaluation resulted in the introduction of models for stress corrosion cracking into Section XI in 2001, and since that time additional models have been added and more are planned. This addition gives Section XI flaw evaluations a complete treatment of all the potential modes of cracking that can occur in components, and details will be provided in Section 32.2.

Since additional crack growth data, for both fatigue and stress corrosion cracking, is periodically made available on a regular basis from additional research testing, the models contained in Section XI are regularly reviewed and updated to ensure their applicability, accuracy, and reflection of the latest known material behaviors. This improved knowledge may lead to more conservative models for crack growth over time. To accommodate such situations, Section XI has adopted an approach to conservatively account for potential increases in crack growth predictions with augmented examinations. The rules of IWB-3600 require that augmented (additional) examinations must be performed at an accelerated pace for situations where a flaw indication was accepted by analytical evaluation. This rule also protects against NDE uncertainties at the location of interest.

The nomenclature used here will be identical to that used in Section XI; any nomenclature that is not present in Section XI will be explained as it appears.

This chapter has been updated using the 2019 Code edition.

History

Warren H. Bamford is the original author of this chapter and has since revised it for all of the subsequent editions including the current online edition.
ASME Piping Codes: B31.3 Process, B31.5 Refrigeration, B31.9 Building Services and ASME Standards for Piping: B31E Seismic Design, B31J Stress I-Factors, B31T Toughness Requirements
Authors: Meyer Jimmy E. , Vilminot Kristi A.
Published: June 2023

This chapter covers the ASME B31.3 Process Piping Code as well as some of the other books in the B31 series.

History

Charles Becht IV was the author of “Chapter 17” titled “B31.3 PROCESS PIPING” for the first-third editions. Chapter 17 of the third edition was revised in its entirety and renumbered as Chapter 36 in the fourth edition authored by Jimmy E. Meyer who enlarged the scope of the chapter to include additional ASME B31 Codes and Standards. Jimmy E. Meyer and Kristi A. Vilmont updated this chapter for the current edition.
ASME Section III Division 4 Fusion Energy Devices Code Rules
Authors: Sowder William K.
Published: June 2023

The specific application of fusion for the future is power generation since, via appropriate plant design, fusion offers the potential to be a clean alternative to nuclear fission. This chapter provides insight into the current and new approaches for fusion energy being used today. These include experimental facilities, new fusion construction projects, and the next-generation fusion facilities. Within the ASME Section III organizational structure there is a Sub-Group “Fusion Energy Devices” (FED), whose charter is to develop the rules for the construction of fusion components. The fusion code rule development is focused on two basic Fusion Device Concepts: Magnetic Confinement Fusion (MCF) (the Tokamak) and Inertial Confinement Fusion, which is primarily laser fusion. The major systems that can make up a typical Tokamak system may include magnets (TF coils, PF coils, central solenoid coils, corrections coils, etc.), target chamber, vacuum vessel, in-vessel coil systems, in-vessel components (such as blanket, divertor, etc.), cryostat, vacuum vessel (VV) over-pressure suppression system, thermal shields, and machine support structure. In order to efficiently develop these new fusion code rules, a Division 4 Fusion Energy Device Roadmap was developed to guide in the development of these Fusion Energy Device Code Rules. This roadmap will help focus committee resources on all areas of the proposed new rules for development, as well as providing project management to this development effort. A phased approach is being used to develop the FED Codes Rules, which includes activities related to developing the direction and concepts for the new Section III, Division 4 Code Rules.
Complete Genome Sequences of the Two Strains Methylorubrum extorquens NBC_00036 and NBC_00404
Authors: Faurdal David , Jørgensen Tue S. , Alvarez-Arevalo Maria , Mourched Anna-Sophie , Sterndorff Eva B. , Charusanti Pep , Weber Tilmann
Published: June 2023

Here, we report the complete genome sequences of
Methylorubrum extorquens
NBC_00036 and
Methylorubrum extorquens
NBC_00404. The genomes were sequenced using the Oxford Nanopore Technologies MinION and Illumina NovaSeq systems. Both genomes are circular, with sizes of 5,661,342 bp and 5,869,086 bp, respectively.
Draft Genome Sequence of Novel
Streptomyces
sp. Strain AJ-1, Isolated from a Leafcutter Ant in Uttarakhand, India
Authors: Choudhary Megha , Naik Bindu , Kumar Vijay , Verma Ankit , Gupta Sanjay
Published: June 2023

We present the draft genome sequence of
Streptomyces
sp. strain AJ-1, which was isolated from a leafcutter ant found in Uttarakhand, India. The genome assembly resulted in 43 contigs, with a combined length of 6,948,422 bp and a GC content of 73.5%. Through genome annotation, we identified 5,951 protein-coding genes and 67 tRNA genes.
Metagenomic Sequencing of Two Cultures Grown on Chemically Deconstructed Plastic Products
Authors: Putman Lindsay I. , Schaerer Laura G. , Wu Ruochen , Kulas Daniel G. , Zolghadr Ali , Ong Rebecca G. , Shonnard David R. , Techtmann Stephen M. , Arbanas Lucille G. , Bannerman Gabriel G. , Cart Brice , Cureton Allen , Doerr Benjamin P. , Jovicevic Zora , Langosch Mary , MacLeod Aaron B. , McCloskey Caden , McNally Avery M. , Monkevich Mykenzie K. , Noecker Adrian , Norris Dylan , Pellizzon Vincent G. , Strom Kylie B. , Taylor Emily E.
Published: June 2023

We report the metagenome sequences of two microbial cultures that were grown with chemically deconstructed plastic products as their sole carbon source. These metagenomes will provide insights into the metabolic capabilities of cultures grown on deconstructed plastics and can serve as a starting point for the identification of novel plastic degradation mechanisms.
Longitudinal and quantitative fecal shedding dynamics of SARS-CoV-2, pepper mild mottle virus, and crAssphage
Authors: Arts Peter J. , Kelly J. Daniel , Midgley Claire M. , Anglin Khamal , Lu Scott , Abedi Glen R. , Andino Raul , Bakker Kevin M. , Banman Bryon , Boehm Alexandria B. , Briggs-Hagen Melissa , Brouwer Andrew F. , Davidson Michelle C. , Eisenberg Marisa C. , Garcia-Knight Miguel , Knight Sterling , Peluso Michael J. , Pineda-Ramirez Jesus , Diaz Sanchez Ruth , Saydah Sharon , Tassetto Michel , Martin Jeffrey N. , Wigginton Krista R.
Published: June 2023

Wastewater-based epidemiology (WBE) emerged during the coronavirus disease 2019 (COVID-19) pandemic as a scalable and broadly applicable method for community-level monitoring of infectious disease burden. The lack of high-resolution fecal shedding data for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) limits our ability to link WBE measurements to disease burden. In this study, we present longitudinal, quantitative fecal shedding data for SARS-CoV-2 RNA, as well as for the commonly used fecal indicators pepper mild mottle virus (PMMoV) RNA and crAss-like phage (crAssphage) DNA. The shedding trajectories from 48 SARS-CoV-2-infected individuals suggest a highly individualized, dynamic course of SARS-CoV-2 RNA fecal shedding. Of the individuals that provided at least three stool samples spanning more than 14 days, 77% had one or more samples that tested positive for SARS-CoV-2 RNA. We detected PMMoV RNA in at least one sample from all individuals and in 96% (352/367) of samples overall. CrAssphage DNA was detected in at least one sample from 80% (38/48) of individuals and was detected in 48% (179/371) of all samples. The geometric mean concentrations of PMMoV and crAssphage in stool across all individuals were 8.7 × 10
4
and 1.4 × 10
4
gene copies/milligram-dry weight, respectively, and crAssphage shedding was more consistent for individuals than PMMoV shedding. These results provide us with a missing link needed to connect laboratory WBE results with mechanistic models, and this will aid in more accurate estimates of COVID-19 burden in sewersheds. Additionally, the PMMoV and crAssphage data are critical for evaluating their utility as fecal strength normalizing measures and for source-tracking applications.

IMPORTANCE

This research represents a critical step in the advancement of wastewater monitoring for public health. To date, mechanistic materials balance modeling of wastewater-based epidemiology has relied on SARS-CoV-2 fecal shedding estimates from small-scale clinical reports or meta-analyses of research using a wide range of analytical methodologies. Additionally, previous SARS-CoV-2 fecal shedding data have not contained sufficient methodological information for building accurate materials balance models. Like SARS-CoV-2, fecal shedding of PMMoV and crAssphage has been understudied to date. The data presented here provide externally valid and longitudinal fecal shedding data for SARS-CoV-2, PMMoV, and crAssphage which can be directly applied to WBE models and ultimately increase the utility of WBE.
Predicting variable gene content in
Escherichia coli
using conserved genes
Authors: Nguyen Marcus , Elmore Zachary , Ihle Clay , Moen Francesco S. , Slater Adam D. , Turner Benjamin N. , Parrello Bruce , Best Aaron A. , Davis James J.
Published: June 2023

Having the ability to predict the protein-encoding gene content of an incomplete genome or metagenome-assembled genome is important for a variety of bioinformatic tasks. In this study, as a proof of concept, we built machine learning classifiers for predicting variable gene content in
Escherichia coli
genomes using only the nucleotide k-mers from a set of 100 conserved genes as features. Protein families were used to define orthologs
,
and a single classifier was built for predicting the presence or absence of each protein family occurring in 10%–90% of all
E. coli
genomes. The resulting set of 3,259 extreme gradient boosting classifiers had a per-genome average macro F1 score of 0.944 [0.943–0.945, 95% CI]. We show that the F1 scores are stable across multi-locus sequence types and that the trend can be recapitulated by sampling a smaller number of core genes or diverse input genomes. Surprisingly, the presence or absence of poorly annotated proteins, including “hypothetical proteins” was accurately predicted (F1 = 0.902 [0.898–0.906, 95% CI]). Models for proteins with horizontal gene transfer-related functions had slightly lower F1 scores but were still accurate (F1s = 0.895, 0.872, 0.824, and 0.841 for transposon, phage, plasmid, and antimicrobial resistance-related functions, respectively). Finally, using a holdout set of 419 diverse
E. coli
genomes that were isolated from freshwater environmental sources, we observed an average per-genome F1 score of 0.880 [0.876–0.883, 95% CI], demonstrating the extensibility of the models. Overall, this study provides a framework for predicting variable gene content using a limited amount of input sequence data.

IMPORTANCE

Having the ability to predict the protein-encoding gene content of a genome is important for assessing genome quality, binning genomes from shotgun metagenomic assemblies, and assessing risk due to the presence of antimicrobial resistance and other virulence genes. In this study, we built a set of binary classifiers for predicting the presence or absence of variable genes occurring in 10%–90% of all publicly available
E. coli
genomes. Overall, the results show that a large portion of the
E. coli
variable gene content can be predicted with high accuracy, including genes with functions relating to horizontal gene transfer. This study offers a strategy for predicting gene content using limited input sequence data.
Reduction of hospital bed cost for inpatient overstay through optimisation of patient flow
Authors: Alharbi Sultanah , Alasmari Abdullah , Hanafy Ehab , Ellawindy Alia
Published: June 2023

Background

Overstay of inpatients is a big challenge to healthcare systems which interferes with the proper utilisation of the available resources and efficient delivery of care. Unnecessary days in the hospital may lead to patient complications including healthcare-associated infections, falls and delirium, which can negatively impact both patient and staff experience. This project aimed to reduce the cost of bed days of inpatient overstay through facilitating the discharge process using a multidisciplinary intervention approach.

Methods

The root causes of inpatient overstay were defined via a multidisciplinary approach. This project applied the extension Deming Cycle method: Find-Organise-Clarify-Understand-Study-Plan-Do-Check-Act (PDCA). Solutions to the root causes which led to process variation were implemented through three PDCA cycles conducted between January 2019 and July 2020.

Results

There was a significant reduction in the total number of overstay inpatients, the total number of overstay days, and the related bed costs in the first 3 quarters of 2019. A significant and sustained improvement in the emergency department average boarding time was attained in the first half of 2019 (reduced from 11.9 hours to 1.7 hours). A total estimated cost saving of SR30 000 000 (US$8 000 000) in terms of operational efficiency was achieved.

Conclusion

Early discharge planning and facilitating the patient discharge process significantly improves the average length of inpatient stay and patient outcomes and decreases hospital costs.
The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease
Authors: Lopetuso Loris Riccardo , Deleu Sara , Godny Lihi , Petito Valentina , Puca Pierluigi , Facciotti Federica , Sokol Harry , Ianiro Gianluca , Masucci Luca , Abreu Maria , Dotan Iris , Costello Samuel Paul , Hart Ailsa , Iqbal Tariq H , Paramsothy Sudarshan , Sanguinetti Maurizio , Danese Silvio , Tilg Herbert , Cominelli Fabio , Pizarro Theresa T , Armuzzi Alessandro , Cammarota Giovanni , Gasbarrini Antonio , Vermeire Séverine , Scaldaferri Franco
Published: June 2023

Background

Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations in study design. These include differences in administered dose, route and frequency of delivery, type of placebo and evaluated endpoints. Although the overall outcomes appear to be promising, they are highly dependent on both donor and recipient factors.

Objective

To develop concensus-based statements and recommendations for the evaluation, management and potential treatment of IBD using FMT in order to move towards standardised practices.

Design

An international panel of experts convened several times to generate evidence-based guidelines by performing a deep evaluation of currently available and/or published data. Twenty-five experts in IBD, immunology and microbiology collaborated in different working groups to provide statements on the following key issues related to FMT in IBD: (A) pathogenesis and rationale, (B) donor selection and biobanking, (C) FMT practices and (D) consideration of future studies and perspectives. Statements were evaluated and voted on by all members using an electronic Delphi process, culminating in a plenary consensus conference and generation of proposed guidelines.

Results and conclusions

Our group has provided specific statements and recommendations, based on best available evidence, with the end goal of providing guidance and general criteria required to promote FMT as a recognised strategy for the treatment of IBD.
Longitudinal bidirectional link between socioeconomic position and health: a national panel survey analysis
Authors: Benderly Michal , Fluss Ronen , Murad Havi , Averbuch Emma , Freedman Laurence S , Kalter-Leibovici Ofra
Published: June 2023

Background

Health inequities can stem from socioeconomic position (SEP) leading to poor health (social causation) or poor health resulting in lower SEP (health selection). We aimed to examine the longitudinal bidirectional SEP-health associations and identify inequity risk factors.

Methods

Longitudinal Household Israeli Panel survey participants (waves 1–4), age ≥25 years, were included (N=11 461; median follow-up=3 years). Health rated on a 4-point scale was dichotomised as excellent/good and fair/poor. Predictors included SEP parameters (education, income, employment), immigration, language proficiency and population group. Mixed models accounting for survey method and household ties were used.

Results

Examining social causation, male sex (adjusted OR 1.4; 95% CI 1.1 to 1.8), being unmarried, Arab minority (OR 2.4; 95% CI 1.6 to 3.7, vs Jewish), immigration (OR 2.5; 95% CI 1.5 to 4.2, reference=native) and less than complete language proficiency (OR 2.22; 95% CI 1.50 to 3.28) were associated with fair/poor health. Higher education and income were protective, with 60% lower odds of subsequently reporting fair/poor health and 50% lower disability likelihood. Accounting for baseline health, higher education and income were associated with lower likelihood of health deterioration, while Arab minority, immigration and limited language proficiency were associated with higher likelihood. Regarding health selection, longitudinal income was lower among participants reporting poor baseline health (85%; 95% CI 73% to 100%, reference=excellent), disability (94%; 95% CI 88% to 100%), limited language proficiency (86%; 95% CI 81% to 91%, reference=full/excellent), being single (91%; 95% CI 87% to 95%, reference=married), or Arab (88%; 95% CI 83% to 92%, reference=Jews/other).

Conclusion

Policy aimed at reducing health inequity should address both social causation (language, cultural, economic and social barriers to good health) and health selection (protecting income during illness and disability).
Effectiveness of Stefan blowing on MHD slip flow of Prandtl–Eyring nanofluid over an elongating sheet with activation energy and viscous-Ohmic dissipation
Authors: Kumbhakar Bidyasagar , Nandi Susmay
Published: June 2023

This work examines the Stefan blowing effect on the magnetized stagnation point flow of Prandtl–Eyring nanoliquid along a nonlinear elongating surface under the influence of numerous slips. In this study, the impressions of internal heat sources, nonlinearly varying radiation, activation energy with binary chemical reactions, viscous dissipation, and Joule dissipation are taken into account. The thermal flux associated with thermal radiation is computed using Rosseland’s approximation for an optically thick environment. The controlling dimensional mathematical equations are transformed into nondimensional representations using appropriate similarity transmissions. Numerical temperature, velocity, and concentration solutions are obtained using a shooting method based on secant iteration and the Runge–Kutta–Fehlberg method. Using tabular and graphical displays of numerical data, the physical effects of a number of relevant parameters on the nanoliquid temperature, velocity, and concentration are examined. By contrasting the current results with information that has already been published for a few limiting circumstances, the validity of the acquired results is demonstrated. The effects of physical features on the local surface drag coefficient, rates of mass and heat transfer are demonstrated using numerical data shown in tabular form. For increasing values of the Stefan blowing parameter, fluid velocity decreased. The fluid temperature tends to rise as a result of thermal radiation.
Impedance spectra of different capacitor technologies
Authors: Kalbitz René
Published: June 2023

This paper reviews the interpretation of impedance and capacitance spectra for different capacitor technologies and discusses how basic electrical characteristics can be inferred from them. The basis of the interpretation is the equivalent circuit for capacitors. It is demonstrated how the model parameters, such as capacitance and equivalent series resistance, can be extracted from the measured spectra. The aspects of measurement accuracy are exemplarily discussed on the measured spectra.
Does financial inclusion catalyze trade
Authors: Wasim Syeda Zuimah , Iftikhar Khurram , Rizvi Syed Zia Abbas
Published: June 2023

This study scrutinizes the effect of financial inclusion (FI) on trade by employing the Newey West standard approach, Feasible Generalized Least Square (FGLS), Pooled Ordinary Least Square (POLS) regression, Fixed Effect Model (FEM) and Random Effect Model (REM) on 24 developing economies from 2004 to 2020. Results found strong, significant and positive association linking FI and trade. Policy recommendations are developing countries should take serious measures to deepen FI which will boost the effect on trade. Furthermore, these economies should expand trade in new markets and use formal financial institutions as channels for carrying out trade transactions.
Inflation-Adjusted Bonds, Swaps, and Derivatives
Authors: Jarrow Robert A. , Yildirim Yildiray
Published: June 2023

The purpose of this article is to review the literature on inflation-adjusted bonds, swaps, and derivatives. The methodology for valuation and risk management of these securities is an application of the foreign currency extension of a standard HJM term structure model. The two “currencies” in the extended model are real and nominal prices. Currently, for their use in monetary policy, the empirical literature primarily uses these models to estimate both the expected inflation rate and the inflation risk premium. A literature investigating the efficiency of the inflation derivative markets and a comparison of the relevant valuation models is almost nonexistent and a fruitful area for future research.
Synthesis and Electrocatalytic Performance of TiO2 Supported on Carbon Nanoparticles Towards Positive Half-Cell Reaction of Hydrogen-1,4p-benzoquinone Flow-Battery
Authors: Khan Irshad U. , Rajmohan K. S. , Seepana Murali Mohan
Published: June 2023

The Hydrogen- 1,4 p-Benzoquinone redox flow battery (H2—BQ RFB) is simple and economic to use with a cell potential of 0.714 V. Carbon-based electrodes are extensively used as electrode materials due to their comprehensive properties but possess poor hydrophilic nature and low electrochemical activity. It is essential to modify carbon-based materials before employing them in battery applications. Because of its low-cost and enhanced catalytic activity, Titanium dioxide (TiO2) is chosen to modify the carbon material. In the present work, TiO2 supported on carbon nanoparticles (TiO2@CNP) electrocatalyst was synthesized by using the ultra-sound assisted sol-gel method for the positive half-cell of H2—BQ RFB. The composition of the sol is optimized by using cyclic voltammetry (CV) analysis. Surface morphology TiO2@CNP coated on carbon paper was carried out using Scanning Electron Microscope (SEM). The TiO2 and carbon interaction bonds were identified using Fourier transform infrared spectroscopy (FTIR). The phase and crystalline nature were identified by using X-ray diffraction (XRD). The activity of the electrode was assessed by CV and Tafel analysis. The electrocatalyst was tested in H2—BQ RFB positive half-cell by galvanostatic charge-discharge and obtained energy efficiency up to 73%.
Prevalence and Predictive Factors of Early Degeneration of Bioprosthetic Mitral Valves: A Single-Center Cohort Study
Authors: Shafiee Akbar , Ayati Aryan , Salimi Elnaz , Sahebjam Mohammad , Salehi Omran Abbas , Hadizadeh Alireza , Zoroufian Arezou
Published: June 2023

Background. Bioprosthetic mitral valves (MV) have limited durability. Dysfunction and degeneration of these valves can lead to reoperation and progressive heart failure. We investigated the frequency and predictors of MV bioprosthesis early degeneration within three years following MV replacement surgery. Methods. In this retrospective cohort study, we retrieved the data of consecutive patients who underwent bioprosthetic MV replacement through midsternotomy at Tehran Heart Center between 2013 and 2019. Based on the reviewed parameters of the bioprosthetic MV in the follow-up echocardiography, the patients were divided into two groups to compare the variables respecting early degeneration. Finally, the predictors of early degeneration were recognized using the Cox regression hazards model. Results. We reviewed and analyzed data of 177 patients from our hospital database. The mean age of the patients was 63.9 ± 11.7 years and 100 (56.5%) were women. 39 (22.0%) patients had experienced early degeneration and two (1.1% of the total) had died during the follow-up period. Patients in the degeneration group tended to have a history of stroke and renal failure, although not statistically significant. The sole independent predictor of early degeneration of bioprosthetic MV was a high MV mean gradient in the first postoperative echocardiography study (HR = 11.01, 95% CI: 4.80–25.24;

P
<
0.001

). Conclusion. About 22.0% of our patients had echocardiographic criteria for early degeneration, and according to our results, increased MV gradients (without considering the reason) in the first postoperative echocardiography were the sole independent predictor for it. Careful valve selection can be essential in reducing early degeneration.
Anticipated vs. Experienced Pain at Site of Spinal Needle Insertion in Patients Undergoing Elective Lower Segment Caesarean Section: Perspective from Resource-Limited Region
Authors: Ghaffar Waleed Bin , Minai Fauzia
Published: June 2023

Background. Despite significant advantages, approximately 20% of pregnant patients refuse spinal anaesthesia in caesarean section due to fear of spinal needle prick. Studies have shown that the patient’s expectation of pain is higher than what they experience in real. The objective was to evaluate the difference between anticipated and actually experienced pain at the spinal needle insertion site in spinal anaesthesia for pregnant women undergoing elective lower segment caesarean section (ELSCS). Method. The cross-sectional study was conducted in a labour room suite of a tertiary care hospital. Results. A total of 50 patients scheduled for ELSCS were included. The median experienced pain at the site of spinal needle insertion was significantly low as compared to anticipated pain (

P

value < 0.01). For the identification of predictors impacting the anticipated and experienced pain, univariate and multivariate regression models were applied. Amsterdam Preoperative Anxiety and Information Scale ≥11 for anticipated pain showed a statistically significant positive correlation in univariate (coefficient: 2.59; 95% CI: 1.49 to 3.68;

P

value < 0.001) and multivariable analyses (coefficient: 2.51; 95% CI: 1.36 to 3.67; P value < 0.001). Thus, anxiety was associated with statistically significant higher anticipated pain. Conclusion. In conclusion, there is a remarkable difference in the obstetric population between anticipated and actually experienced pain at the site of spinal needle insertion in ELSCS.
Stress Is Associated with Quality of Life Reduction among Health Professionals in Vietnam: A Multisite Survey
Authors: Hanh Le Thi Kieu , Van Toan Ngo , Hai Vu Minh
Published: June 2023

Stress in healthcare workers is increasingly common in recent times. Stress can have negative effects on the mental health and quality of life of healthcare workers. This study is aimed at measuring the quality of life and determining the relationship between quality of life and stress of health professionals in some hospitals in Vietnam. A cross-sectional descriptive study was conducted on 520 health professionals working at Hanoi Medical University Hospital and Thai Binh Medical University Hospital. The World Health Organization Quality-of-Life Scale (WHOQOL-BREF) and the Depression, Anxiety, and Stress Scale-21 Items (DASS-21) scale were used to assess the quality of life and the stress status of healthcare workers. Multivariate regression was performed to measure the relationships between stress and quality of life. Results showed that the level of stress of health workers according to the DASS-21 scale at mild, moderate, severe, and very severe was 10.7%, 8.7%, 5.6%, and 2.9%, respectively. The mean score of overall quality of life was

60.97
±
11.39

. Health workers under stress had a decrease in quality of life scores in physical, mental, social, and environmental domains. Stressed health workers had a reduced quality of life. Attention should be paid to providing appropriate interventions to reduce stress and improve the quality of life in healthcare workers.
TABLE 3 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Multicovariate Cox regression model for OS, PFS, and DMFS among patients with breast cancer (World IBC Consortium dataset; n = 314)
Figure S4 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Authors: Lombardi Simona , Goldman Aaron R. , Tang Hsin-Yao , Kossenkov Andrew V. , Liu Heng , Zhou Wei , Herlyn Meenhard , Lin Jianhuang , Zhang Rugang
Published: June 2023

CARM1 expression confers the sensitivity to SCD1 inhibition.
Supplementary Table S1 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Supplementary Table S1. Full list of candidate regulators that were significantly enriched for 60 Reactome and WikiPathways, as identified by Affymetrix Genechip microarray analysis.
Supplementary Figure S4 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Supplementary Figure S4. Graphical representation of the physical protein-protein interaction network involved in modulating MELK activity in MDA-MB-231 cells.
FIGURE 1 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Clinical relevance of MELK in breast cancer and expression of MELK in breast cancer cell lines. A,MELK mRNA levels in HR−HER2+, HR+HER2−, HR+HER2+, and TNBC tumors in the World Consortium IBC dataset, analyzed by multiple comparison using a general linear model. Data are presented as mean ± SD. – represents median, X represents mean. B, IHC images (200× magnification) showing MELK protein expression in normal epithelial tissue and luminal, HER2+, and TNBC breast tumors. Correlation between MELK mRNA levels (<7 or ≥7) and OS, PFS, and DMFS in patients in the overall cohort (C) and among those with TNBC (D), determined by the Kaplan–Meier method. MELK mRNA levels (E) and protein levels (F) in TNBC and non-TNBC cells. Inset, correlation between MELK mRNA and protein levels in TNBC cell lines. In F, α-tubulin was used as a loading control. MELK mRNA levels were determined using quantitative reverse transcriptase PCR.
Acquired Perforating Dermatosis as a Paraneoplastic Feature: A Case Report, Literature Review, and Novel Association
Authors: Imran Nashat
Published: June 2023

Kyrle’s disease is an uncommon form of acquired transepidermal elimination dermatosis frequently associated with diabetes mellitus and chronic kidney disease. An association with malignancy has been sporadically reported in the literature. Here, we describe the clinical course of a diabetic patient with end-stage renal disease who developed this disorder as a herald to a regionally advanced renal cell carcinoma. We provide a focused literature review and rationale for the definitive categorization of acquired perforating dermatosis as a potential paraneoplastic manifestation of systemic malignancies. Clinicopathological correlation and prompt communication among clinicians for occult malignancies are always warranted. Furthermore, we describe a novel association of one of the subtypes of acquired perforating dermatosis with such malignancies.