bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring Gene Flow in the Cultivation of Transgenic Barley
Authors: Ritala A. , Nuutila A. M. , Aikasalo R. , Kauppinen V. , Tammisola J.
Published: July 2017

Genetic engineering is becoming a useful tool in the improvement of plants and plant‐based raw materials. Varieties with value‐added traits are developed for nonfood use in industrial and medical production, and different production lines must be kept separate. For good management practices, knowledge of relevant gene flow parameters is required. In the present study, pollen‐mediated dispersal of transgenes via cross‐fertilization was examined. A transgenic barley (Hordeum vulgare L.) line carrying a marker gene coding for neomycin phosphotransferase II (nptII) was used as a pollen donor. For maximum resolution, a cytoplasmically male‐sterile barley line was utilized as recipient and the flow of nptII transgene was monitored at distances of 1, 2, 3, 6, 12, 25, 50, and 100 m from the donor plots of 225 and 2000 m2 Male‐fertile plots at a distance of 1 m were included to measure the transgene flow in normal barley. The number of seeds obtained from male‐sterile heads diminished rapidly with distance and only a few seeds were found at distances of 50 and 100 m. Molecular genetic analysis (polymerase chain reaction—PCR) revealed that all seeds obtained from male‐sterile heads at a distance of 1 m were transgenic, as anticipated. However, only 3% of the distant seeds (50 m) actually carried the transgene, whereas most of them resulted from fertilization with nontransgenic background pollen. This background pollen was mainly due to pollen leakage in some male‐sterile heads. In normal male‐fertile barley, the cross‐fertilization frequency with transgenic pollen varied from 0 to 7% at a distance of 1 m, depending on weather conditions on the heading day. We conclude that, because of competing self‐produced and nontransgenic background pollen, the possibility of cross‐pollination is very low between a transgenic barley field and an adjacent field cultivated with normal barley. However, adequate isolation distances and best management practices are needed for cultivation of transgenic barley.
Commercialization of innovations: peculiarities of sales policy at innovation active enterprise
Authors: Olefirenko Oleg , Shevliuga Olena
Published: July 2017

This study investigates the management process of innovations commercialization and its essence. Nowadays, establishing and ensuring the efficiency of innovations commercialization process is an objective precondition that creates material values. It also creates new demand in the market, shifting the emphasis from the production of enterprises to various management fields, creates new ways of capital substitution and enhances the level of innovation activity profitability. The aim of the research is to analyze indicators and characteristics of implemented instruments of sales policy at innovation active enterprises in order to estimate the influence of sales policy parameters to innovation level. There are many factors and trends that motivate enterprises to search for new ways to ensure their competitiveness. Findings revealed that there is a need to develop new technologies that ensures the profitability growth and activities optimization through capital mobility into areas with higher productivity and profitability. Sales policy is a necessary precondition for operation performance and further development of enterprises. Sales policy parameters significantly affect the level of innovation activity of industrial enterprises. Each of sales policy tools has an individual impact on the enterprise activity dynamics and can have positive or negative effect.
Measuring the customer satisfaction based on SERVQUAL model (case study: Mellat Bank in Tehran city)
Authors: Oskooii Nasrin , Albonaiemi Ebrahim
Published: July 2017

Today marketers seek the ways and information to create loyal customers, because it reduces the marketing and operations costs and increases the benefits. In every organization, whether manufacturing or service, customers is the most important factor of ensuring the survival of organization. If the organization succeeds in attracting customers and creating their loyalty, the field of its growth and long term survival can be provided. It is possible to achieve this through studying and planning by management, and this will lead at the end to the comprehensive recognition of customer needs. Since focusing on factors of customers’ satisfaction has a significant effect in banking, so, identifying the categories and priorities of these factors are important. All hypotheses of this study are approved both by Student’s t-test and Friedman test. The results of study indicated that the factors of reliability, accountability and credit factors, respectively, have more importance in order of priority. In credit factors: variety of banking services (providing any kind of services which customers need); in accountability factors: speed in providing banking services; in reliability factors: proper behavior of staff is considered of the most priority.
Zero-valent aluminum-mediated degradation of Bisphenol A in the presence of common oxidants
Authors: Arslan-Alaton I. , Olmez-Hanci T. , Dogan M. , Ozturk T.
Published: July 2017

The use of a commercial, nano-scale zero-valent aluminum (ZVA) powder was explored for the treatment of aqueous Bisphenol A (BPA). The study focused on the (i) activation of hydrogen peroxide (HP) and persulfate (PS) oxidants with ZVA to accelerate BPA degradation, (ii) comparison of the treatment performance in pure and real surface water (SW) samples, (iii) effects on toxicity and (iv) reuse potential of ZVA nanoparticles after ZVA/HP and ZVA/PS treatments. In pure water, ZVA coupled with HP or PS provided an effective means of BPA treatment particularly when PS was employed as the oxidant. On the other hand, in BPA-spiked SW, the ZVA/HP treatment combination outperformed ZVA/PS oxidation in terms of BPA removal, whereas ZVA/PS oxidation was superior in terms of organic carbon removal. According to the bioassays conducted in pure and real SW samples with the marine photobacteria Vibrio fischeri and the freshwater microalgae Pseudokirchneriella subcapitata, the toxicity response of BPA and its oxidation products was sensitive to the test organism and water matrix. The inhibitory effect of the reaction solution increased at the early stages of ZVA/PS treatment. The reuse potential of the ZVA/HP treatment system was higher than that of the ZVA/PS treatment system.
Biomethanization of the Mixture of Cattle Manure, Pig Manure and Poultry Manure in Co-Digestion with Waste Peels of Pineapple Fruit and Content of Chicken-Gizzard - Part II: Optimization of Process Variables
Authors: Aworanti O. A. , Agarry S. E. , Ogunleye O. O.
Published: July 2017

Background:

The indiscriminate discharge of industrial waste, agricultural-biomass waste, waste of municipal, domestic and kitchen waste has negatively impacted on the environment and human health. It is very pertinent to reduce these impacts to the barest minimum through conversion of the waste to useful products. The conversion of these wastes to generate alternative energy to fossil fuel through the technology of anaerobic fermentation is one of the viable and more fascinating options for the management of waste.

Objective:

To investigate the interactive effect and optimization of process parameters of temperature, total solid content and feed/inoculum ratio on the biomethanization of the mixture of cattle manure, pig manure and poultry manure in co-digestion with waste peels of pineapple fruit and content of chicken-gizzard.

Method:

Full-factorial central composite design of experiment (RCCD) of the response surface method (RSM) was adopted to assess the possible interactive effects of the process variables and the optimal parameters (i.e. optimization) for biogas/biomethane production in an anaerobic digester.

Result:

The process variables had a significant (P < 0.05) positive and negative interactive effect on the biomethanization process. A second-order quadratic polynomial regression model which is statistically significant (p < 0.0001) was respectively obtained for cumulative biogas yield (CBY), biomethane content (BC) and hydraulic retention time (HRT). Temperature of 55.2°C; total solid content of 6.25%; and feed/inoculums ratio of 1:2 were found to be the optimum values required to attain a predicted optimum values of 6.261 dm3/g CBY, 71.54% BC within a minimum 8 days of HRT. At this optimum process conditions, the experimental observed maximum CBY, and BC with a minimum HRT were found to be 6.217 dm3/g of slurry, 71.10% and 7 days, respectively.

Conclusion:

Biogas/biomethane generation through co-substrate anaerobic fermentation of animal waste with waste of fruits constitute a reasonable and applicable renewable energy alternative and this can be optimized through response surface methodology.
Misinterpretation of Gram Stain from the Stationary Growth Phase of Positive Blood Cultures for Brucella and Acinetobacter Species
Authors: Bazzi Ali M. , Al-Tawfiq Jaffar A. , Rabaan Ali A.
Published: July 2017

Introduction:

Acinetobacter baumanniiandBrucellaspecies are Gram-negative organisms that are vulnerable to misinterpretation as Gram-positive or Gram-variable in blood cultures.

Objective:

We assess the random errors in gram stain interpretation to reduce the likelihood of such errors and therefore patient harm.

Methodology:

Aerobic and anaerobic blood cultures from two patients in an acute care facility in Saudi Arabia were subjected to preliminary Gram-staining. In case 1, VITEK-2 Anaerobe Identification, repeat Gram staining from a blood agar plate, Remel BactiDrop™ Oxidase test, Urea Agar urease test and real-time PCR were used to confirm presence ofBrucellaand absence ofCoryneformspecies. In case 2, repeat Gram- staining from the plate and the vials, VITEK-2 Gram-Negative Identification, real-time PCR and subculture on to Columbia agar, blood agar, and MacConkey agar were carried out to identifyA. baumannii.

Results:

In case 1, initially pleomorphic Gram-positive bacteria were identified.Coryneformspecies were suspected. Tiny growth was observed after 24 h on blood agar plates, and good growth by 48 h. Presence ofBrucellaspecies was ultimately confirmed. In case 2, preliminary Gram-stain results suggested giant Gram-positive oval cocci. Further testing over 18-24 h identifiedA. baumannii.

Conclusions:

Oxidase test from the plate and urease test from the culture vial is recommended after apparent identification of pleomorphic Gram-positive bacilli from blood culture, once tiny growth is observed, to distinguishBrucellafromCorynebacteriumspecies. If giant Gram-positive oval cocci are indicated by preliminary Gram-staining, it is recommended that the Gram stain be repeated from the plate after 4-6 h, or culture should be tested in Triple Sugar Iron (TSI) medium and the Gram stain repeated after 2-4 h incubation.
Membranous Nephropathy Associated with Atheroembolism
Authors: Uchiyama Kiyotaka , Takemura Tamiko , Ishibashi Yoshitaka
Published: July 2017

Membranous nephropathy (MN) is one of the most common biopsy diagnoses in adults, and it has been associated with chronic infections, autoimmune diseases, malignancies, and drugs. However, MN associated with cholesterol crystal emboli has never been reported. Here we present a patient with MN as an unusual manifestation of atheroembolism.

A 75-year-old man with worsening renal function after catheter ablation developed moderate proteinuria and underwent a renal biopsy. Findings on light, immunofluorescence, and electron microscopy were all compatible with membranous nephropathy. Moreover, one occluded interlobular artery contained a pathognomonic, biconvex, needle-shaped cleft, which indicated a cholesterol crystal emboli. The degree of proteinuria was in parallel with the number of eosinophils, which indicated a close relationship between MN disease activity and renal atheroembolism. Hypereosinophilic syndrome secondary to atheroembolism may cause MN; thus, corticosteroid therapy was likely to be effective.
When Pain is Beyond Biology - A Case of Fake Leprosy
Authors: Avila Lazslo Antonio , Pozetti Eurides Maria de Oliveira , Fares Gislaine Fusco , Soubhia Rosa Maria Cordeiro , Oliveira Marilia Capuco , Tomiyasu Andreia Yumi
Published: July 2017

Background:

Pain is a complex phenomenon that implies pathophysiological processes and psychosocial components. A 56-year-old female patient complaining of pain and presenting with multiple mild physical signs was examined by a multidisciplinary team from the Ear-Nose-Throat, Dermatology, Hematology, General Clinics, and Psychiatry and Psychology Departments.

Objective:

To present a significant case where pain is primarily caused by psychological conflicts.

Method:

A multidisciplinary approach, with medical and psychological interventions.

Results:

The patient was deeply convinced; she had been contaminated by leprosy. Her enrooted personal beliefs, including religion and moral conflicts, seem to be the primary cause for her putative ‘disease’, a condition that was not confirmed by exhaustive exams.

Conclusion:

Pain normally is related to several factors, including biological, psychological and cultural. Some complex cases should be investigated by a multidisciplinary team of specialists, in order to identify extra-physiological components.
Children's Participation in Library Space Improvement Programme
Authors: Atmodiwirjo Paramita , Yatmo Yandi Andri
Published: July 2017

This paper illustrates a physical improvement programme in a primary school library through a participatory process involving children in designing and renovating the space. The improvement of library space has contributed positively to promoting children's active use of the library space. The involvement of children in the process has also promoted their positive attitude and sense of belonging toward the space. Commitment to building the whole school community becomes a challenge during the process and beyond. Promoting children's active role in the development, management and maintenance of the space become important to ensure sustainability after the programme.
End-Users' Sense of Home in Mass-Housing Based on Maslow's Theory
Authors: Asad Poor S. Javad
Published: July 2017

"Sense of home" in mass housing depends on the degree of congruity of the environment with end-users' different motivations, which would be achieved by their participation. End-users participation in mass housing is quite challenging and critical because they are inaccessible and absent. This paper aims at investigating the interrelationships between end-users motivational factors and different participatory modes/levels. An overview of theories and concepts on human motivation and different participatory modes/levels results in explaining the degree of readability of different motivations, and the application of various participatory methods in representing these motivations.
Influence of Recreational Facilities among Adolescents towards Leisure Time Physical Activity (LTPA)
Authors: Abd-Latif Rozita , Mohd Nor Maizan , Omar-Fauzee Mohd Sofian , Ahmad Abdul Razak
Published: July 2017

The purpose of this study is to identify the influence of recreational facilities towards leisure physical activities among youth. As many as 913 respondents aged between 13 to 17 years old from four districts (Seremban, Muar, Kota Star and Kuantan) in Peninsular Malaysia, were chosen through a layered cluster random sampling technique.  The results show that the safety of the environment is at a moderate level (busy road: M=3.51, SP=1.31; stray dog: M=3.46, SP=1.38; crime: M=3.23, SP=1.33) and it has no connection with the involvement of youths in LTPA (r=-0.01, p>0.05). It is also discovered that sports facilities limit them from undergoing physical activities during leisure hours. However, facilities are easy to be used (75%) by youths and this leads to a significant relationship with LTPA (r=0.10, p<0.05). The implication of this research shows that the physical environment is pivotal in order to increase the level of youth involvement in overall free time physical activities.  Thus, it is suggested that these physical activities can only take more of the teenagers' time if they are carried out in environments which are creative, comfortable, safe and user-friendly.
The Influence of Sensory Gardens on the Behaviour of Children with Special Educational Needs
Authors: Hussein Hazreena
Published: July 2017

This study explores the use of sensory gardens by observing the zones and how they are utilised by children with special educational needs. Methods applied were interviews, observation and behaviour mapping, which was used in conjunction with the affordance theory. Affordance was categorised by landscape furniture, the soft and hard landscape in relation to three categories of activities: Sensory stimulation, physical and social skills. The findings discovered continuous pathways that link the sensory garden to the site context, had easy access to the features and had the highest number of users. This study also found that users spent a longer time in zones where sensory, rather than aesthetic value, was emphasised.
EVALUATION OF ALTERNATIVE RAILWAY CONNECTION ACCESS AT JAKARTA SOEKARNO HATTA INTERNATIONAL AIRPORT
Authors: Aprilischa Ayu , Muthohar Imam , Moxon Richard
Published: July 2017

Traveling between the center of Jakarta and Soekarno Hatta International Airport (SHIA) is further constrained by the limited number of main routes available which likely cannot be accommodated in the future by road based transport modes alone. Hence, the airport needs to develop airport surface access to accommodate its network. The aim of this research is to analyze the railway access system for developing the system of SHIA using multi criteria analysis in the selection of alternative route alignment of the railway line and a qualitative study in data collection within the research design. Development of the criteria includes technical, economic, environmental and spatial aspect. Three alternatives have been proposed in this analysis, i.e. through West Jakarta, through North and West Jakarta and through North and Central Jakarta. The results show that alternative 3 (through North and Central Jakarta) can give implications to the airport users, i.e. providing a high standard of the rail link in a well-timed manner and a cost-effective public transport link. Improving the multi-modal access to the airport will improve the supply of employment to business, lead to urban regeneration around station locations, and improve Greater Jakarta Metropolitan Area regional competitiveness.
DEVELOPMENT OF WARNING CRITERIA FOR LAHAR FLOW DISASTER IN GENDOL RIVER AREA OF MOUNT MERAPI
Authors: Fibriyantoro Ernowo Ary
Published: July 2017

The eruption of Mount Merapi in 2010 leads to the lahar flow disaster in the region of the mountain slopes. Due to the impact caused by the lahar flow, it is important to develop warning criteria for lahar flow disaster with a simple method corresponding to the limitation of existing data and parameters. One of the methods is by analyzing rainfall data to predict the occurrence of lahar flow in Gendol River. It applies the setting of standard rainfall for warning and evacuation of sediment disasters based on Guidelines for the Development of Warning and Evacuation System against Sediment Disasters in Developing Countries, published by the Ministry of Land, Infrastructure, and Transport (MLIT) Infrastructure Development Institute - Japan, 2004. This study analyzed the critical line (CL) which can be used to predict the occurrence of lahar flow based on the rain characteristics namely working rainfall and rainfall intensity. Furthermore, it can be established by warning line (WL) and the evacuation line (EL) as a basis for determining the standard rainfall for warning (R1) and standard rainfall for evacuation (R2). The value of R1 obtained ± 6 mm and R2 ± 29 mm. The value of R1 and R2 are strongly influenced by the availability of rainfall data and occurrence of lahar flow. The results of this research were expected to be used as input for the warning criteria development of early warning system lahar flow disaster on the slopes of Mount Merapi, particularly in the area of Gendol River.
SNAKE LINE ANALYSIS FOR LAHAR FLOW WARNING SYSTEM (CASE STUDY IN PUTIH RIVER, MOUNT MERAPI)
Authors: Yulinsa Nina
Published: July 2017

Lahar flow in the region of Mount Merapi after an eruption of 2010 is still considered potentially to happen and threat the region along the river from the upstream. The development of warning criteria against the potential occurrence of lahar flow is a thing that should be done continuously to accommodate dynamics data availability (rainfall data and lahar flow occurrence data), although with limited data. This study aims to develop lahar warning system applying snake line as a rain phenomenon in Putih catchment area which will affect the occurrence of lahar flow and to evaluate the success rate of snake line for deciding the warning system. This study used the main reference from Guidelines for Development of Warning and Evacuation System against Sediment Disasters in Developing Countries released by Ministry of Land, Infrastructure and Transport Infrastructure Development Institute – Japan (2004). This research was conducted through several stages, i.e. secondary data collection in the form of rainfall data, lahar flow occurrence data, making correlation graph between rainfall intensity and working rainfall, determination of critical line, warning line and evacuation line. The results show that standard rainfall for warning and evacuation alert in Putih River are 22 mm, and 49 mm, respectively. The accuracy of warning criteria and the evacuation criteria against snake line for warning line is 30%, evacuation line is 61% and the critical line is 83%. The behavior of snake line that indicates lahar flow occurrence in Putih River forming an angle of 40o up to 45o.
Depression, anxiety and stress severities in multiple sclerosis patients using injectable versus oral treatments
Authors: Al-Hussain Fawaz , Al-Salloum Noura , Alazwary Naael , Saeedi Jameelah , Howaidi Sara , Daif Abdulkader
Published: July 2017

Aim:
Studies on multiple sclerosis in Saudi Arabia remain scant, particularly studies on the psychological aspects. This study measures severities of depression, anxiety and stress, and compares them to the used disease-modifying treatment.
Materials & methods:
Cross-sectional study using a phone questionnaire targeting 452 Saudi patients with relapsing-remitting multiple sclerosis following in King Khalid University Hospital, King Fahad Medical City or Security Forces Hospital.
Results:
From 235 patients, 149 used interferons, 58 used fingolimod and 28 used natalizumab. Depression scores were similar among all demographic and drug groups. Interferons versus fingolimod anxiety scores were significantly different (p = 0.035). Stress scores were within normal limits.
Conclusion:
Mild anxiety was higher among interferon users, which could be due to injection anxiety reasons.
Comparative effectiveness of surgery versus antibiotics in acute appendicitis: a systematic review
Authors: Talutis Stephanie D , Drake Frederick Thurston
Published: July 2017

Aim:
To review outcomes of surgical and antibiotic management of acute appendicitis.
Methods:
11 prospective studies comparing surgical versus antibiotic management of acute appendicitis over a 21-year period were reviewed.
Results:
Antibiotic management is successful in most cases of uncomplicated acute appendicitis. The need for crossover in management and recurrent appendicitis were low among all studies. For those patients who ultimately required surgery, no increased complications were observed.
Conclusion:
The decision to use antibiotics to treat acute appendicitis should be held to the same standards of diagnostic rigor as surgical management. Antibiotics may be safely recommended in patients with high surgical risk, such as the elderly or those with multiple comorbidities.
HUBUNGAN TINGKAT PENGETAHUAN TENTANG HIV/AIDS DENGAN PERILAKU SEKSUAL PRANIKAH PELAJAR
Authors: Rahayu Inggit , Jaelani Abdul Khodir , Rismawanti Venny
Published: July 2017

Rendahnya pengetahuan HIV/AIDS dikalangan remaja mempengaruhi sikap remaja pada prilaku seksual pranikah sehingga dapat meningkatkan kerentanan remaja untuk tertular HIV/AIDS. Tujuan penelitian ini untuk mengetahui hubungan tingkat pengetahuan tentang HIV/AIDS dengan Prilaku Seksual Pranikah Pelajar. Jenis penelitian ini bersifat analitik observasional dengan pendekatan crossectional. Pengambilan data dilakukan secara prospektif (Januari 2017). Populasi dalam penelitian ini adalah siswa-siswi SMA Negeri 1 Rengat. Pengambilan sampel dengan menggunakan acidental sampling dengan jumlah sampel sebanyak 90 orang. Analisis data menggunkan uji univariat dan uji bivariat. Hasil penelitian menunjukan bahwa mayoritas siswa-siswa SMA Negeri 1 rengat memiliki tingkat pengetahuan HIV/AIDS yang baik sebanyak 49 siswa (54%) dengan sikap yang tidak mendukung terhadap prilaku seksual pranikah sebanyak 57 siswa (63%). Penelitian ini juga menunjukan bahwa ada hubungan antara tingkat pengetahuan tentang HIV/AIDS dengan perilaku seksual pranikah pelajar SMA Negeri 1 Rengat (Pvalue < 0,05).
La resiliencia en adolescentes de 13 a 15 años y jóvenes de 16 a 18 años privados de la libertad del centro de reclusión Luis A. Rengifo en la ciudad de Ibagué.
Authors: Quintero Padilla Amparo , Jabela Cubillos Jessica Tatiana , Rocha Palma Maria Consuelo , Serna Aguiar Angela
Published: July 2017

Este proyecto presenta un rastreo de información bibliográfica desde Europa hasta Colombia, sobre resiliencia en adolescentes que han enfrentado una situación adversa, la “pérdida de su libertad”.
La pregunta de investigación a resolver fue: ¿La condición de haber perdido la libertad influye en la capacidad resiliente? Y para conocer el impacto de la capacidad resiliente de los adolescentes, se diseñó
el cuestionario Análisis de la Resiliencia en Adolescentes “A.R.A.” compuesto por cinco categorías: Sentirse bien solo, Ecuanimidad, Perseverancia, Satisfacción personal y Confianza en sí mismo, dichas categorías se tomaron como referencia de la Escala de Resiliencia presentada por Wagnild y Young (1993). Se cumplió con la primera fase del pilotaje con adolescentes y jóvenes de género masculino pertenecientes al Centro de Reclusión para Menores Infractores “Politécnico Luis A. Rengifo”. Se recomienda someter el cuestionario en una segunda fase con población femenina con las mismas condiciones de pérdida de la libertad para completar su validación. Los resultados de dicho cuestionario fueron analizados mediante el software SPSS.
¿La sociedad post-conflicto (la paz del cementerio) o la gestión social del conflicto mediante la participación democrática?: una mirada psicosocial del conflicto armado en Colombia
Authors: Miranda Rodríguez Miguel Ángel
Published: July 2017

La sociedad post-conflicto que se vaticina en el discurso gubernamental a propósito de los diálogos en La Habana (Cuba), invita a pensar en las representaciones que se hacen de la sociedad, en el entendido que dichas representaciones están en el origen del conflicto que se pretende dirimir. El documento explora las alternativas a este respecto, descubriendo el anacronismo de las posturas estatales, la invisibilidad de la propuesta guerrillera y la ausencia de visiones alternas, que deberían hacer parte de la discusión. Al final se concluye con la necesidad de oxigenar el proceso, mediante la admisión de temas que convoquen la diversidad de intereses ciudadanos y tiendan a generar un ambiente de confianza, sobre la seguridad proveniente de prestaciones sociales estabilizadas.
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance
Authors: Lee Su-Yeon , Lee Hui-Young , Song Jae-Hwi , Kim Goon-Tae , Jeon Suwon , Song Yoo-Jeong , Lee Jae Sung , Hur Jang-Ho , Oh Hyun Hee , Park Shi-Young , Shim Soon-Mi , Yoo Hyun Joo , Lee Byung Cheon , Jiang Xian-Cheng , Choi Cheol Soo , Park Tae-Sik
Published: July 2017

Sphingolipids have been implicated in the etiology of chronic metabolic diseases. Here, we investigated whether sphingolipid biosynthesis is associated with the development of adipose tissues and metabolic diseases. SPTLC2, a subunit of serine palmitoyltransferase, was transcriptionally upregulated in the adipose tissues of obese mice and in differentiating adipocytes. Adipocyte-specific SPTLC2-deficient (aSPTLC2 KO) mice had markedly reduced adipose tissue mass. Fatty acids that were destined for the adipose tissue were instead shunted to liver and caused hepatosteatosis. This impaired fat distribution caused systemic insulin resistance and hyperglycemia, indicating severe lipodystrophy. Mechanistically, sphingosine 1-phosphate (S1P) was reduced in the adipose tissues of aSPTLC2 KO mice, and this inhibited adipocyte proliferation and differentiation via the downregulation of S1P receptor 1 and decreased activity of the peroxisome proliferator–activator receptor γ. In addition, downregulation of SREBP (sterol regulatory element–binding protein)-1c prevented adipogenesis of aSPTLC2 KO adipocytes. Collectively, our observations suggest that the tight regulation of de novo sphingolipid biosynthesis and S1P signaling plays an important role in adipogenesis and hepatosteatosis.
Thyroid Hormone Coordinates Pancreatic Islet Maturation During the Zebrafish Larval-to-Juvenile Transition to Maintain Glucose Homeostasis
Authors: Matsuda Hiroki , Mullapudi Sri Teja , Zhang Yuxi , Hesselson Daniel , Stainier Didier Y.R.
Published: July 2017

Thyroid hormone (TH) signaling promotes tissue maturation and adult organ formation. Developmental transitions alter an organism's metabolic requirements, and it remains unclear how development and metabolic demands are coordinated. We used the zebrafish as a model to test whether and how TH signaling affects pancreatic islet maturation, and consequently glucose homeostasis, during the larval to juvenile transition. We found that exogenous TH precociously activates the β-cell differentiation genes pax6b and mnx1 while downregulating arxa, a master regulator of α-cell development and function. Together, these effects induced hypoglycemia, at least in part by increasing insulin and decreasing glucagon expression. We visualized TH target tissues using a novel TH-responsive reporter line and found that both α- and β-cells become targets of endogenous TH signaling during the larval-to-juvenile transition. Importantly, endogenous TH is required during this transition for the functional maturation of α- and β-cells in order to maintain glucose homeostasis. Thus, our study sheds new light on the regulation of glucose metabolism during major developmental transitions.
Influence Behavior Toward Consumer Buying Decisions In House Type 36. Lagan Pangka Pekanbaru
Authors: Azhari Azhari
Published: July 2017

The purpose of this study was to determine whether the factor of cultural, social, personal and psychological Influential Home Buying Decision Against Type 36 PT. Lagan PangkaPekanbaru. Data analysis technique using multiple linear regression analysis. The samples used were 58 respondents with accidental sampling technique. Data collection techniques by questionnaire. Based on the results of this study concluded that the factor of cultural, social, personal and psychological significantly influence the purchase decision Houses Type 36 PT. Lagan PangkaPekanbaru. Test the correlation coefficient (R) independent variable on the dependent variable are very strong closeness of 0.951 and a contribution of independent variables on the dependent variable (R2) was 89,70%Keywords : Factor Culture, Social, Personal, Psychological and Purchase Decision
Analisis Pengaruh Program Nasional Pemberdayaan Masyarakat Mandiri Perkotaan (Pnpm Mp) Terhadap Produktifitas Kerja Dan Kesejahteraan Masyarakat
Authors: Mahendra Bayu Putra
Published: July 2017

Penelitian ini bertujuan untuk menganalisis pengaruh Bantuan Langsung Masyarakat (BLM) Bidang Lingkungan (infrastruktur) dari Program Nasional Pemberdayaan Masyarakat (PNPM) Mandiri perkotaan terhadap produktivitas kerja masyarakat di Kecamatan Denpasar Utara. Untuk menganalisis pengaruh Bantuan Langsung Masyarakat (BLM) Bidang Lingkungan (infrastruktur) dari Program Nasional Pemberdayaan Masyarakat (PNPM) Mandiri perkotaan terhadap kesejahteraan masyarakat melalui produktivitas kerja masyarakat di Kecamatan Denpasar Utara. Observasi lapangan penyeberan kuesioner dan wawancara. Program PNPM Mandiri Perkotaan bidang infrastruktur berpengaruh positif terhadap Produktivitas di Kecamatan Denpasar Utara Produktivitas berpengaruh positif terhadap Kesejahteraan Masyarakat PNPM Mandiri Perdesaan di Kecamatan Denpasar Utara. Program PNPM Mandiri Perkotaan bidang infrastruktur berpengaruh positif terhadap Kesejahteraan Masyarakat PNPM Mandiri Perdesaan di Kecamatan Denpasar Utara.
Alternativas de salud en el Tercer Mundo
Authors: Weiss-Altaner Eric R.
Published: July 2017

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Authors: Peña Raúl De la
Published: July 2017

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José Tavares de Araujo (comp.). Difusão de inovaçoes na indústria brasileira : três estudos de caso, Río de Janeiro, IPEA-INPES, 1976.
Authors: Nadal Egea Alejandro
Published: July 2017

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Susan Eckstein, The Poverty of Revolution. The State and the Urban Poor in Mexico, Princeton, Princeton University Press, 1977
Authors: Guzmán Marco V.
Published: July 2017

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Alejandro Foxley (comp.). Income Distribution in Latin America, Cambridge, Cambridge University Press, 1976. 244 p.
Authors: Peña Raúl De la
Published: July 2017

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Clive V. Thomas. Dependence and Transformation : The Economics of the Transition to Socialism, Nueva York, Monthly Review Press, 1974. 327 p.
Authors: Graizbord Boris
Published: July 2017

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El crecimiento demográfico y el desarrollo económico latinoamericano
Authors: Urquidi Víctor L.
Published: July 2017

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Raanan Weitz (compilador). Rural planning in Developing Countries : report on the second Rehovot Conference, Israel, august 1963. Londres : Routledge & Kegan Paul, 1965. viii, 443 p.
Authors: Boltvinik Julio
Published: July 2017

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Tasas de natalidad y tasas de ahorro
Authors: Leff Nathaniel H.
Published: July 2017

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Alvaro López Toro. Análisis demográfico de los censos colombianos : 1951 y 1964. Bogotá : Centro de Estudios sobre Desarrollo Económico, Universidad de los Andes, 1968. 94 p.
Authors: Arévalo Jorge V.
Published: July 2017

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El desarrollo económico y el crecimiento de la población
Authors: Urquidi Victor L.
Published: July 2017

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Organización para la Cooperación y el Desarrollo Económico (OCDE), Science and Development Pilot Teams Project. Evaluation Conference. París, 1968. 260 p.
Authors: Urquidi Víctor L.
Published: July 2017

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Manuel Mateos Fournier, Alfredo Román, Augusto Valdez y Rodolfo Pineda. Nuevas aportaciones para la evaluación del problema del aborto criminal en México. México : Fundación para Estudios de la Población, 1969. 29 p.
Authors: Quilodrán Julieta
Published: July 2017

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J. D. B. DeBow [ed.], Statistical View of the United States. Demographic Monographs, v. 5, Nueva York, Gordon and Breach Science Publishers, 1970, 400 p.
Authors: Alba Francisco
Published: July 2017

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Previsión de necesidades de mano de obra de calificación alta. Posibilidad de aplicación de las comparaciones internacionales al caso de México
Authors: Debeauvais Michel
Published: July 2017

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Producción de salud y mortalidad
Authors: Weiss-Altaner Eric R.
Published: July 2017

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El estudio sociológico del amor corporeizado: la construcción de un objeto de estudio entrelazando teorías y niveles analíticos
Authors: García Andrade Adriana , Sabido Ramos Olga Alejandra
Published: July 2017

En este escrito se desarrollan algunas reflexiones surgidas en el proceso de construcción del objeto de estudio: el amor de pareja desde el nosotros y su relación con el problema del Sentido (Sinn). De manera general planteamos que el Sentido -entendido como significado y orientación- sirve como puente para vincular niveles analíticos (semántica-situación-enminded bodies) y propuestas teóricas aparentemente inconmensurables.  En nuestro caso de estudio, la semántica del amor (imágenes, discursos, símbolos) pre-existe a la situación y orienta los significados generados en ésta por las parejas que ‘envejecen juntas’.  Finalmente, los cuerpos con mente (enminded bodies) experimentan sentido pero lo etiquetan usando la semántica social y los significados generados en situación. En el trabajo se desarrolla cómo es posible esta conexión de niveles analíticos a través del Sentido.
On the Road: Connectivity infrastructures in Southeast Asia
Authors: Martinez Oliva Juan Carlos
Published: July 2017

This paper considers the problems surrounding the implementation of road infrastructure plans in a policy perspective. As the main pillar of regional connectivity, road networks provide the link across national markets, foster strong and sustainable economic growth, help meeting people’sbasic needs, and promote trade and competiveness. It is argued that planning, implementing, and managing good transportation infrastructures poses a series of challenges that require competence, good governance, and the availability of funds. Such problems become more complex when road projects encompass different states and become transnational. The regional dimension of connectivity involves both opportunities and risks; a cooperative attitude by all parties is viewed as the best ingredient to achieve a positive balance. Since most countries cannot still rely on domestic resources, the paper stresses the role of virtuous policies in directing capital flows from abroad towards the infrastructural projects of Southeast Asia.
Treatment of a case with anti-MDA5 antibody positive clinically amyopathic dermatomyositis complicated with stomach cancer and colon cancer
Authors: Nishiguchi Mana , Furukawa Fukumi , Ikeda Takaharu
Published: July 2017

A 74-year-old woman noticed an edematous erythema on the right upper eyelid two months before her first medical examination, and slight fever, arthralgia and edematous erythema on the forearms and palms around the time of the first medical examination. She presented with typical skin lesions of dermatomysitis including Gottron’s signs and a heliotrope rash without any abnormal muscle symptoms. An examination by gastrointestinal endoscopy and a computed tomography scan of the chest revealed that she was complicated with stomach cancer (Stage ⅠA), colon cancer　(Stage Ⅰ) and interstitial pneumonia (IP). She was diagnosed with anti-MDA5 antibody positive clinically amyopathic dermatomyositis (CADM) complicated with two cancers. Because the IP became aggravated, she was treated with corticosteroids at an initial dose of 1 mg/kg/day and immunosuppressive therapies. Tacrolimus was discontinued due to thrombocytopenia and, she also had an allergic reaction to cyclophosphamide. The administration of azathioprine at a dose of 75mg/day prevented the exacerbation of IP. We were able to be taper the dose of corticosteroids, and endoscopic stomach surgery and abdominal rectal surgery was performed. The anti-MDA5 antibody is a characteristic myositis-specific autoantibody associated with CADM and IP, which may cause a poor prognosis. CADM complicated with malignancy occurs less frequently than similarly complicated dermatomyositis and, to the best of our knowledge, this is the first case of CADM complicated with two cancers.
Caracterização epidemiológica da tuberculose pulmonar no Estado do Maranhão, entre o período de 2008 a 2014
Authors: Zagmignan Adrielle , Alves Matheus Silva , Sousa Eduardo Martins de , Lima Neto Lidio Gonçalves , Sabbadini Priscila Soares , Monteiro Silvio Gomes
Published: July 2017

A Tuberculose (TB) é uma doença infecto contagiosa que representa um dos principais problemas sociais, econômicos e de saúde publica no mundo. A tuberculose (TB) representa um dos principais problemas sociais, econômicos e de saúde pública no mundo. Em 2013 foram estimados que 9 milhões de pessoas desenvolveram tuberculose e 1,5 milhões de mortes associadas com epidemias de TB. Brasil está entre os 22 países que concentra 80% dos casos de TB no mundo.Esse trabalho teve como objetivo caracterizar o perfil epidemiológico dos pacientes com tuberculose pulmonar no período de 2008-2014 no estado do Maranhão. Trata-se de estudo descritivo-retrospectivo com abordagem quantitativa de casos novos de Tuberculose Pulmonar notificado ao Sistema de Informação de Agravos de Notificação (SINAN) ocorridos no Maranhão entre 2008 e 2014. Foram notificados 12.384 casos novos de tuberculose pulmonar. Nesse período, o Maranhão foi o décimo primeiro lugar no Brasil e o quarto da região Nordeste. Do mesmo modo, como acontece na população geral do Brasil e mundial, o sexo masculino apresenta maiores números de novos casos em comparação com o sexo feminino. A quantidade de pessoas acometidas por tuberculose esta na faixa etária de 20-39 anos (44,4%) Portanto, os pacientes com tuberculose pulmonar no maranhão no período de 2008 a 2014 apresentaram-se como sendo a maioria do sexo masculino com idade entre 20 e 39 anos, com ensino fundamental incompleto e de cor parda.Palavras-chave: Tuberculose pulmonar. Maranhão. Epidemiologia.
Pháp luật giải quyết tranh chấp tiêu dùng Việt Nam dưới góc nhìn so sánh với quốc tế
Authors: Nguyễn Điệp Trọng , Nguyễn Đạt Tiến
Published: July 2017

Sau 7 năm thi hành Luật Bảo vệ quyền lợi người tiêu dùng, các quy định pháp luật về giải quyết tranh chấp tiêu dùng đã được bổ sung và hoàn thiện đáng kể theo hướng mở rộng các phương thức giải quyết tranh chấp tiêu dùng. Tuy nhiên, thực tiễn cho thấy việc giải quyết tranh chấp còn chưa tương xứng với thực tiễn, công cụ pháp lý và thể chế chưa hỗ trợ được nhiều trong quá trình giải quyết tranh chấp. Dưới góc độ so sánh với kinh nghiệm lập pháp của một số quốc gia, các quy định pháp luật và thể chế trong giải quyết tranh chấp tiêu dùng cần tiếp tục hoàn thiện trong thời gian tới.
ANALISIS PENGARUH HARI PERDAGANGAN TERHADAP RETURN SAHAM DI BURSA EFEK INDONESIA : PENGUJIAN MENGGUNAKAN GARCH ( GENERALIZED AUTOREGRESSIVE CONDITIONAL HETEROSKEDASTICITY)
Authors: Cahyaningdyah Dwi , Faidah Faridhatun
Published: July 2017

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh hari perdagangan terhadap return saham di Bursa Efek Indonesia. Subjek penelitian ini adalah perusahaan-perusahaan dalam indeks LQ45 di Bursa Efek Indonesia. Teknik pengambilan sampel dilakukan dengan metode sampling jenuh. Ditemukan jumlah observasi sebanyak 1.697 observasi data harian harga saham penutupan selama tahun 2007-2015. Analisis data yang digunakan adalah analisis GARCH. Hasil penelitian menunjukkan bahwa ada pengaruh hari perdagangan terhadap return saham di Bursa Efek Indonesia periode 2007-2015 dimana ditemukan return saham yang negatif pada hari Senin (Monday Effect) dan return terbesar yang terjadi pada hari Jumat (Weekend effect). Sementara itu, fenomena week four effect tidak ditemukan pada penelitian ini karena Monday effect tidak hanya digerakkan oleh return negatif yang terjadi pada Senin minggu keempat dan kelima saja namun juga digerakkan oleh return negatif pada Senin minggu kedua dan ketiga. Pada penelitian ini, fenomena bad Friday juga tidak ditemukan karena tidak hanya return negatif hari Jumat saja yang mempengaruhi return negatif hari Senin (Monday Effect) tetapi juga dipengaruhi oleh return positif pada hari umat minggu sebelumnya.
Video Making Project To Improve Students‟ Autonomy And Ability In Transactional And Interpersonal Conversations
Authors: Arfiyantama Riko
Published: July 2017

Speaking as one of the productive skills is considered difficult forforeign language learners. One of the efforts to solve the difficulty is improvingthe students‟ autonomy in speaking practice. The study is about the use ofvideo making to improve students‟ autonomy and speaking ability intransactional and interpersonal conversations. The objective of the study wasto find out how video making project is implemented in classroom. Students ofSMA 1 Limbangan were taken as the subject of the study. This study usedclassroom action research by conducting a pre-test, first cycle, and second cycleactivities particularly focused on speaking. The students‟ speaking achievementwas scored based on the video they had made. The students were also asked tofill the questionnaire to know their improvements in autonomy. The result ofthe research showed that the average score percentage of autonomy in pre-testwas 68%, cycle I result was 87% and cycle II result was 89%. While the resultalso showed that the average of students‟ speaking achievements in pre-test was60, cycle I was 68, and Cycle II was 73.It can be concluded that using VideoMaking project in teaching transactional and interpersonal conversations canimprove the students‟ speaking competence as well as autonomy.
Flouting Maxim By Sherlock Holmes and dr. Watson In Tv Series Of Sherlock Season
Authors: Affifatusholihah Lina , Setyawan Agustinus Hary
Published: July 2017

AbstractIn running daily activities, people will always meet and interact with other people, and language is a medium that is used by humans to interact with each other. In a conversation or discussion, everyone should pay attention to the four maxims in order that there are no errors in communication. However, it is not uncommon that the four rules above are breached by the speakers. This is called non-observance of the maxims, and one of a non-observance of the maxims that often occurs in is flouting maxim. The aims of this paper are to describe types of maxims that are flouted by Sherlock Holmes and dr. Watson as well as to describe how the maxims are flouted in Sherlock TV series season 1. This research used qualitative descriptive method. The researcher classifies the utterances to know what kind of maxim which are flouted, categorizes those into the category based on the Grice’s theory of Cooperative Principle, namely: maxim of quantity, quality, relation and manner. The research procedure begin by searching the script in the internet, matching the utterances in the script and in film and sorting the utterances between Sherlock Holmes and dr. Watson as well observing every word or sentence which are flouted by the main characters. The findings find that all kinds of maxims are flouted by Sherlock and dr. Watson. The result of analysis shows that the maxim flouted when the speakers say something irrelevant; something roguishness or lied to hide the truth in the form of rhetorical question; the information becomes more or too informative than what is required; and something obscurity of expression, ambiguity, or unnecessary prolixity.
Improving Students’ Reading Skill By Using Quantum Learning
Authors: Martika Wini , Hermayawati Hermayawati
Published: July 2017

AbstractThere were many students who had problem in comprehending the text. Based on the problem, this research aimed at finding out :(1) the procedures to improve students’ reading skill using Quantum Learning (QL); (2) the students’ interest in their learning reading using QL; (3) the students’ improvement in comprehending the texts using QL. This research involved 32 students of class VII C of SMPN 1 Seyegan. The researcher used pre-test and post- test to analyse the students’ improvement. It was found that the students’ average score in pre-test was 52,7, and the first post-test was 67,4. The second post-test was 89,8. It means that the post-test was higher than pre-test. Besides, the students also had been well motivated during the learning process. In conclusion, the findings of this research showed that the QL could improve the students’ reading skill. Hence, she suggested to use QL as an alternative method in improving the students’ reading skill.