bluuebunny/crossref_metadata_2025 huggingface dataset:
Occurrence of Banned and Currently Used Herbicides, in Groundwater of Northern Greece: A Human Health Risk Assessment Approach
Authors: Parlakidis Paraskevas , Rodriguez Maria Soledad , Gikas Georgios D. , Alexoudis Christos , Perez-Rojas Greivin , Perez-Villanueva Marta , Carrera Alejo Perez , Fernández-Cirelli Alicia , Vryzas Zisis
Published: July 2022

The presence of pesticide residues in groundwater, many years after their phase out in European Union verifies that the persistence in aquifer is much higher than in other environmental compartments. Currently used and banned pesticides were monitored in Northern Greece aquifers and a human health risk assessment was conducted. The target compounds were the herbicides metolachlor (MET), terbuthylazine (TER), atrazine (ATR) and its metabolites deisopropylatrazine (DIA), deethylatrazine (DEA) and hydroxyatrazine (HA). Eleven sampling sites were selected to have representatives of different types of wells. Pesticides were extracted by solid-phase extraction and analyzed by liquid chromatography. MET was detected in 100% of water samples followed by ATR (96.4%), DEA and HA (88.6%), DIA (78.2%) and TER (67.5%). ATR, DIA, DEA, HA, MET and TER mean concentrations detected were 0.18, 0.29, 0.14, 0.09, 0.16 and 0.15 μg/L, respectively. Obtained results were compared with historical data from previous monitoring studies and temporal trends were assessed. Preferential flow was the major factor facilitating pesticide leaching within the month of herbicide application. Moreover, apparent age of groundwater and the reduced pesticide dissipation rates on aquifers resulted of long-term detection of legacy pesticides. Although atrazine had been banned more than 18 years ago, it was detected frequently and their concentrations in some cases were over the maximum permissible limit. Furthermore, human health risk assessment of pesticides was calculated for two different age groups though drinking water consumption. In all examined wells, the sum of the HQ values were lower than the unity. As a result, the analyzed drinking water wells are considered safe according to the acute risk assessment process. However, the presence of atrazine residues causes concerns related with chronic toxicity, since ATR R values were greater than the parametric one of 1 × 10−6 advised by USEPA, for both age groups.
Epidemiology and Clinical Characteristics of Older Patients Transferred from Long-Term-Care Hospitals (LTCHs) to Emergency Departments by a Comparison with Non-LTCHs in South Korea: A Cross-Sectional Observational Study
Authors: Yun Soon Young , Lim Ji Yeon , Kim Eun , Oh Jongseok , Lee Duk Hee
Published: July 2022

The South Korean population is rapidly aging, and the number of older patients in long-term-care hospitals (LTCHs) continues to increase. This study aims to investigate the epidemiologic data, characteristics, and clinical outcomes of patients aged 65 years and older transferred from LTCHs to emergency departments (EDs). This is a retrospective study based on National Emergency Department Information System data from 2014 to 2019. Of the 6,209,695 older patients visiting EDs for disease treatment, 211,141 (3.4%) were transferred from LTCHs. Among patients from LTCHs (211,141), 24.2% were discharged from EDs, 43.0% were admitted to general wards, 20.7% were hospitalized in intensive care units, 3.1% were transferred to another hospital, 6.1% returned to LTCHs, and 2.1% died in EDs. ED stays were the longest for those returning to LTCHs (710.49 ± 1127.43 min). Foley catheterization (40.3%) was most frequently performed in preventable ED visits. In South Korea, older patients being discharged from the ED or returning to LTCHs, after being transferred from LTCHs to EDs, increased. ED stays among older LTCH patients were longer than among non-LTCH older patients, contributing to congestion. To reduce avoidable transfer to EDs from LTCHs, it is necessary to discuss policies, such as expanding appropriate medical personnel and transitional treatment.
Assessing Relationships between Physically Demanding Work and Late-Life Disability in Italian Nonagenarian Women Living in a Rural Area
Authors: Lombardi Gemma , Pancani Silvia , Lorenzini Francesca , Vannetti Federica , Pasquini Guido , Frandi Roberta , Turcan Nona , Razzolini Lorenzo , Molino Lova Raffaello , Cecchi Francesca , Macchi Claudio
Published: July 2022

As more and more persons live into their 90s and beyond, investigating causes of disability in the oldest-old population is relevant for public health implications to plan preventive strategies and rehabilitation interventions. A negative association between physically demanding work and midlife physical function has been shown, but there is a paucity of longitudinal studies investigating possible work-related long-term effects in the oldest old. This study investigates the relationship between physically demanding work exposure and late-life physical performances, disability, general health status, and quality of life in a sample of women aged 90 years and over inside the Mugello Study. Sociodemographic data, cognitive and functional status, lifestyle, medical history, drug use, and work history were collected from 236 participants. Farmers had a lower percentage of individuals with preserved independence in basic activities of daily living compared to other occupations. However, in the multivariate analysis, only a higher cognitive function remained associated with functional independence. While confirming the well-known association between cognitive and functional decline in very old age, our results do not support the hypothesis that the negative effects of physical work exposure observed in midlife are relevant to predict disability in nonagenarian women.
Nicotine Exerts Cytotoxic Effects in a Panel of Healthy Cell Lines and Strong Irritating Potential on Blood Vessels
Authors: Chioran Doina , Sitaru Adrian , Macasoi Ioana , Pinzaru Iulia , Sarau Cristian Andrei , Dehelean Cristina , Dinu Stefania , Szuhanek Camelia , Zetu Irina Nicoleta , Serafin Andra Cristine , Rivis Mircea , Poenaru Marioara , Dragoi Razvan
Published: July 2022

The use of tobacco products is a major global public health issue, as it is the leading cause of preventable death worldwide. In addition, nicotine (NIC) is a key component of electronic and conventional cigarettes. Although nicotine’s addictive potential is well known, its health effects are not entirely understood. Thus, the main objective of the present study was to evaluate its toxicological profile both in vitro, at the level of three healthy cell lines, and in ovo, at the level of the chorioallantoic membrane. Five different concentrations of nicotine were used in keratinocytes, cardiomyocytes, and hepatocytes for the purpose of evaluating cell viability, cell morphology, and its impact on nuclei. Additionally, the hen’s egg test on the chorioallantoic membrane (HET-CAM) method was used to assess the biocompatibility and irritant potential of the chorioallantoic membrane. Across all cell lines studied, nicotine was proven to be significantly damaging to cell viability, with the highest concentration tested resulting in less than 2% viable cells. Moreover, the morphology of cells changed dramatically, with alterations in their shape and confluence. Nicotine-induced cell death appears to be apoptotic, based on its impact on the nucleus. In addition, nicotine was also found to have a very strong irritating effect on the chorioallantoic membrane. In conclusion, nicotine has an extremely strong toxicological profile, as demonstrated by the drastic reduction of cell viability and the induction of morphological changes and nuclear alterations associated with cellular apoptosis. Additionally, the HET-CAM method led to the observation of a strong irritating effect associated with nicotine.
The Identification of Subphenotypes and Associations with Health Outcomes in Patients with Opioid-Related Emergency Department Encounters Using Latent Class Analysis
Authors: Chhabra Neeraj , Smith Dale L. , Maloney Caitlin M. , Archer Joseph , Sharma Brihat , Thompson Hale M. , Afshar Majid , Karnik Niranjan S.
Published: July 2022

The emergency department (ED) is a critical setting for the treatment of patients with opioid misuse. Detecting relevant clinical profiles allows for tailored treatment approaches. We sought to identify and characterize subphenotypes of ED patients with opioid-related encounters. A latent class analysis was conducted using 14,057,302 opioid-related encounters from 2016 through 2017 using the National Emergency Department Sample (NEDS), the largest all-payer ED database in the United States. The optimal model was determined by face validity and information criteria-based metrics. A three-step approach assessed class structure, assigned individuals to classes, and examined characteristics between classes. Class associations were determined for hospitalization, in-hospital death, and ED charges. The final five-class model consisted of the following subphenotypes: Chronic pain (class 1); Alcohol use (class 2); Depression and pain (class 3); Psychosis, liver disease, and polysubstance use (class 4); and Pregnancy (class 5). Using class 1 as the reference, the greatest odds for hospitalization occurred in classes 3 and 4 (Ors 5.24 and 5.33, p < 0.001) and for in-hospital death in class 4 (OR 3.44, p < 0.001). Median ED charges ranged from USD 2177 (class 1) to USD 2881 (class 4). These subphenotypes provide a basis for examining patient-tailored approaches for this patient population.
Illicit Substance Use and the COVID-19 Pandemic in the United States: A Scoping Review and Characterization of Research Evidence in Unprecedented Times
Authors: Vo Anh Truc , Patton Thomas , Peacock Amy , Larney Sarah , Borquez Annick
Published: July 2022

We carried out a scoping review to characterize the primary quantitative evidence addressing changes in key individual/structural determinants of substance use risks and health outcomes over the first two waves of the COVID-19 pandemic in the United States (US). We systematically queried the LitCovid database for US-only studies without date restrictions (up to 6 August 2021). We extracted quantitative data from articles addressing changes in: (a) illicit substance use frequency/contexts/behaviors, (b) illicit drug market dynamics, (c) access to treatment and harm reduction services, and (d) illicit substance use-related health outcomes/harms. The majority of 37 selected articles were conducted within metropolitan locations and leveraged historical timeseries medical records data. Limited available evidence supported changes in frequency/behaviors/contexts of substance use. Few studies point to increases in fentanyl and reductions in heroin availability. Policy-driven interventions to lower drug use treatment thresholds conferred increased access within localized settings but did not seem to significantly prevent broader disruptions nationwide. Substance use-related emergency medical services’ presentations and fatal overdose data showed a worsening situation. Improved study designs/data sources, backed by enhanced routine monitoring of illicit substance use trends, are needed to characterize substance use-related risks and inform effective responses during public health emergencies.
The Impact of Digital Economy on the Efficiency of Green Financial Investment in China’s Provinces
Authors: Tian Xiangyu , Zhang Yuanxi , Qu Guohua
Published: July 2022

The global digital operation of finance has accelerated, and the transformation and upgrading of the financial industry has been fully empowered by digital technology, which has promoted the development of traditional financial industry toward green finance. Accelerating the pace of China’s entry into the digital economy era has given the green financial industry new opportunities in its digital transformation. Therefore, the research reported in this paper selects provincial panel data and discusses the impact efficiency of the digital economy on green financial investment in China by static panel OLS and the threshold model method, and constructs a threshold model with regional industry scale and green financial audit as threshold variables. These steps are used to analyze the nonlinear characteristics of digital economy and green financial efficiency. The results show that the digital economy can improve the overall efficiency of China’s green finance, and there are two threshold effects with regional industry scale as the threshold variable and one threshold effect with green financial audit support as the threshold variable. The results show that the development of a digital economy improved the investment efficiency of green finance in all provinces of China. In addition, through our research, we found that the application of the digital economy in green finance can reduce the imbalance of regional economic development. China should also strengthen the supervision of green auditing to promote the development of new green financial formats.
Bayesian Spatial Modeling of Diabetes and Hypertension: Results from the South Africa General Household Survey
Authors: Ogunsakin Ropo E. , Ginindza Themba G.
Published: July 2022

Determining spatial links between disease risk and socio-demographic characteristics is vital in disease management and policymaking. However, data are subject to complexities caused by heterogeneity across host classes and space epidemic processes. This study aims to implement a spatially varying coefficient (SVC) model to account for non-stationarity in the effect of covariates. Using the South Africa general household survey, we study the provincial variation of people living with diabetes and hypertension risk through the SVC model. The people living with diabetes and hypertension risk are modeled using a logistic model that includes spatially unstructured and spatially structured random effects. Spatial smoothness priors for the spatially structured component are employed in modeling, namely, a Gaussian Markov random field (GMRF), a second-order random walk (RW2), and a conditional autoregressive (CAR) model. The SVC model is used to relax the stationarity assumption in which non-linear effects of age are captured through the RW2 and allow the mean effect to vary spatially using a CAR model. Results highlight a non-linear relationship between age and people living with diabetes and hypertension. The SVC models outperform the stationary models. The results suggest significant provincial differences, and the maps provided can guide policymakers in carefully exploiting the available resources for more cost-effective interventions.
Socioeconomic Inequalities in the Prevalence of Diabetes in Argentina: A Repeated Cross-Sectional Study in Urban Women and Men
Authors: Rojas-Roque Carlos , Hernández-Vásquez Akram , Azañedo Diego , Bendezu-Quispe Guido
Published: July 2022

This study measured the socioeconomic inequalities in the prevalence of diabetes between 2005 and 2018 in an urban Argentinian population. Data were obtained from the repeated cross-sectional surveys “National Survey of Risk Factors” (ENFR is its acronym in Spanish). From 2005 to 2018, four rounds of ENFR were administered to men and women over 18 years of age. Concentration curves (CC) and the Erreygers concentration index (ECI) were used to describe the socioeconomic inequalities in diabetes’ prevalence. A decomposition analysis was performed to determine the contribution of each variable to inequality in diabetes’ prevalence. Data from 41,219 (2005), 34,583 (2009), 32,232 (2013), and 29,094 (2018) individuals were analyzed. Women reported a greater prevalence of diabetes compared with men for all the years included. According to the CC and ECI, we found no evidence of inequality in men throughout all study years. For women, throughout all years, the CCs were above the line of equity, and the ECIs during all the years were negative and different from zero (p < 0.01). For women, we found no evidence of a reduction in inequalities between 2005 and 2018 (p = 0.475). The socioeconomic inequality for women was largely driven by public insurance, primary and secondary education, and employment. Diabetes’ prevalence was not associated with socioeconomic status in men, while the prevalence of diabetes in women was more concentrated among poorer women. During the 13 years, there was no evidence of a reduction of inequality in women, noting that interventions must prioritize and should focus on the main contribution of inequalities, such as education and employment.
Risk Factors for COVID-19 in a Retired FDNY WTC-Exposed Cohort
Authors: Cleven Krystal L. , Zeig-Owens Rachel , Goldfarb David G. , Schwartz Theresa , Prezant David J.
Published: July 2022

We evaluated the incidence and risk factors for COVID-19 in a prospectively followed cohort of Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed workers, thus reducing the potential for selection bias, a limitation in published studies of hospitalized individuals. Participants were retired FDNY WTC-exposed rescue/recovery workers with ≥1 medical visit between 1 March 2020 and 1 August 2021. The cumulative incidence was calculated using self-reported COVID-19 diagnoses. Cox regression was performed to evaluate the association of WTC-exposure and COVID-19, adjusting for history of comorbidities, age, race, work assignment (emergency medical service providers vs. firefighter), and sex. The cumulative incidence of COVID-19 was 130 per 1000. The adjusted models showed the risk of infection was greater in those with highest WTC exposure versus less exposure (hazard ratio (HR) = 1.14 (95% CI 1.00–1.31)). Older age was associated with a lower risk of infection HR = 0.97 (95% CI 0.96–0.98). WTC-associated diseases (obstructive airways disease and interstitial lung disease) were not COVID-19 risk factors. This study is the first to show an association between WTC exposure and the risk of COVID-19. While participants are retired from FDNY work, the youngest individuals may still be in the workforce, explaining why younger age was a significant risk for COVID-19.
Relationship between Anthropometric Measures and Anxiety Perception in Soccer Players
Authors: Martínez-Rodríguez Alejandro , Peñaranda-Moraga Marcelo , Vicente-Martínez Manuel , Martínez-Moreno Miguel , Cuestas-Calero Bernardo J. , Soler-Durá Jorge , Yáñez-Sepúlveda Rodrigo , Muñoz-Villena Antonio Jesús
Published: July 2022

In the sports context, it has been corroborated that the physical demands of presenting an “ideal” body configuration have been associated with different psychological variables, such as self-esteem, anxiety and personality dimensions, such as perfectionism. Specifically, there is evidence that anthropometric measures may be closely related to psychological indicators. A total of 33 male soccer players (18.12 ± 1.24 years) participated in the investigation. Anthropometric assessments were carried out following the ISAK standards for the restricted profile. All of them completed the Competitive Trait Anxiety Inventory (CTAI-2D) in its Spanish version. The percent fat was calculated using Withers (density) and Siri equations. The ∑7 skinfolds were used to calculate this. After statistical analysis, significant mean differences were observed in the somatic anxiety dimension (valence) and a medium–large effect size. Regarding correlations, the significantly negative relationship between self-confidence (intentionality) and somatic anxiety (valence) was noteworthy. The relationship between psychological variables and anthropometric measurements was corroborated, showing the need for interdisciplinary work between psychologists and nutritionists who do not ignore the physical health and psychological well-being of the soccer player.
A Systematic Review of Interventions Related to Body Awareness in Childhood
Authors: Ahn Si Nae
Published: July 2022

Body image involves perceptions, attitudes, and beliefs concerning one’s body, while body schema involves the sensorimotor capacities to control movement and posture. A review study is needed to obtain sufficient data to determine the effect of body awareness on the normal development of children. This study is a systematic review of interventions related to body awareness among typically developing children. Studies focusing on interventions related to body awareness from 2010 to 2021 were analyzed and extracted from four major scientific databases, and the three that met the inclusion criteria were analyzed. Methods were analyzed by frequency, and the results were analyzed by calculating effect sizes. Two studies involved a nonrandomized two-group design and a single-case experimental study. Two studies targeted early childhood, and one study focused on middle childhood. This review indicates that determining the effectiveness of interventions related to body awareness is necessary for typically developing children because body awareness is a potential influencing factor in their development. Additional research is needed to determine the effectiveness of body awareness assessment tools and interventions.
PROSHADE Protocol: Designing and Evaluating a Decision Aid for Promoting Shared Decision Making in Opportunistic Screening for Prostate Cancer: A Mix-Method Study
Authors: Lumbreras Blanca , Parker Lucy Anne , Alonso-Coello Pablo , Mira-Bernabeu Javier , Gómez-Pérez Luis , Caballero-Romeu Juan Pablo , Pertusa-Martínez Salvador , Cebrián-Cuenca Ana , Moral-Peláez Irene , López-Garrigós Maite , Canelo-Aybar Carlos , Ronda Elena , Guilabert Mercedes , Prieto-González Antonio , Hernández-Aguado Ildefonso
Published: July 2022

Background: Opportunistic prostate-specific antigen (PSA) screening may reduce prostate cancer mortality risk but is associated with false positive results, biopsy complications and overdiagnosis. Although different organisations have emphasised the importance of shared decision making (SDM) to assist men in deciding whether to undergo prostate cancer screening, recent evaluations show that the available decision aids fail to facilitate SDM, mainly because they do not consider the patients’ perspective in their design. We aim to systematically develop and test a patient decision aid to promote SDM in prostate cancer screening, following the Knowledge to Action framework. Methods: (1) Feasibility study: a quantitative survey evaluating the population and clinician (urologists and general practitioners) knowledge of the benefits and risks derived from PSA determination and the awareness of the available recommendations. Focus groups to explore the challenges patients and clinicians face when discussing prostate cancer screening, the relevance of a decision aid and how best to integrate it into practice. (2) Patient decision aid development: Based on this data, an evidence-based multicomponent SDM patient decision aid will be developed. (3) User-testing: an assessment of the prototype of the initial patient decision aid through a user-testing design based on mix-methods (questionnaire and semi-structured review). The decision aid will be refined through several iterative cycles of feedback and redesign. (4) Validation: an evaluation of the patient decision aid through a cluster-randomised controlled trial. Discussion: The designed patient decision aid will provide balanced information on screening benefits and risks and should help patients to consider their personal preferences and to take a more active role in decision making. Conclusions: The well-designed patient decision aid (PDA) will provide balanced information on screening benefits and risks and help patients consider their personal preferences.
COVID-19 Risk Management and Stakeholder Action Strategies: Conceptual Frameworks for Community Resilience in the Context of Indonesia
Authors: Rela Iskandar Zainuddin , Ramli Zaimah , Firihu Muhammad Zamrun , Widayati Weka , Awang Abd Hair , Nasaruddin Nasaruddin
Published: July 2022

The coronavirus disease (COVID-19) pandemic has affected people’s lives globally. Indonesia has been significantly affected by this disease. COVID-19 has also affected certain social and economic aspects of Indonesia, including community resilience. Through a variety of contexts and geographic locales, we explore the previously mentioned concept of resilience. From existing literature reviews, we develop a holistic framework for community resilience during the COVID-19 pandemic. Then, we formulate crucial factors for community resilience during the COVID-19 pandemic: natural capital, social capital, human capital, stakeholder engagement, community participation, technology, and communication. Strategic stakeholder action in the community resilience domain has facilitated increases in economic as well financial capital for adapting to and surviving deficits in productivity in the face of the COVID-19 pandemic. This study is a reflection on and a comparative review of the existing literature from different countries.
Heterogeneity among Homeless Australian Women and Their Reasons for Homelessness Entry
Authors: Warburton Wayne A. , Papic Marina , Whittaker Elizabeth
Published: July 2022

Many women become homeless each year, both women who are alone and women with children. Both groups face substantial risks to their physical and mental health, as do the children of homeless mothers. Little is known about the similarities and differences between these two groups in terms of their demographic characteristics, their circumstances on presentation to specialist homelessness services, and the factors that have contributed to their homelessness. The current study analysed data from 163 single mothers with children and 126 lone women who presented to a specialist homelessness service in Australia. It found some similarities between groups, but also considerable heterogeneity. Single mothers were more likely to be younger, to have been born overseas, and to have been homeless in the past 12 months. Lone women were more likely to have medical issues, a mental health condition, addiction issues, admission to a psychiatric ward in the past 12 months, and to not be in the labour force. Implications for service delivery are discussed.
Estimating the Decoupling between Net Carbon Emissions and Construction Land and Its Driving Factors: Evidence from Shandong Province, China
Authors: Li Mengcheng , Liu Haimeng , Yu Shangkun , Wang Jianshi , Miao Yi , Wang Chengxin
Published: July 2022

Human activities and land transformation are important factors in the growth of carbon emissions. In recent years, construction land for urban use in China has expanded rapidly. At the same time, carbon emissions in China are among the highest in the world. However, little is known about the relationship between the two factors. This study seeks to estimate the carbon emissions and carbon sequestrations of various types of land based on the land cover data of 137 county-level administrative regions in Shandong Province, China, from 2000 to 2020.The study estimated the carbon emissions for energy consumption using energy consumption data and night-time light images, hence, net carbon emissions. The Tapio decoupling coefficient was used to analyze the decoupling between the net carbon emissions and construction land, and where the model for the decoupling effort was constructed to explore the driving factors of decoupling. The results showed that net carbon emissions in Shandong Province continued to increase, and the areas with high carbon emissions were concentrated primarily in specific districts of the province. The relationship between net carbon emissions and construction land evolved from an expansive negative decoupling type to a strong negative decoupling type. Spatially, most areas in the province featured an expansive negative decoupling, but the areas with a strong negative decoupling have gradually increased. The intensive rate of land use and efficiencies in technological innovation have restrained carbon emissions, and they have contributed to an ideal decoupling situation. Although the intensity of carbon emission and the size of the population have restrained carbon emissions, efforts towards decoupling have faded. The degree of land use has facilitated carbon emissions, and in recent years, efforts have been made to achieve an ideal decoupling. The method of estimation of net carbon emissions devised in this research can lend itself to studies on other regions, and the conclusions provide a reference for China, going forward, to balance urbanization and carbon emissions.
The COVID-19 Experience: Creativity as an Identity Attractor for Young People Facing the Developmental Challenges
Authors: Sica Luigia Simona
Published: July 2022

The study focuses on identifying the impacts of the COVID experience on young people and exploring whether, during the pandemic period, adolescents and young adults resorted to flexible and creative coping strategies, which may have served as resources. The participants consisted of 70 Italian freshmen (18 males and 52 females) aged 18 to 21, attending their first year of university. Adopting a narrative approach, we identified seven creativity functions and two interpretative factors, supporting the idea that creativity may have constituted a psychological resource for young people during the COVID-19 pandemic. Furthermore, the findings suggest that creativity can be configured as an identity attractor. Implications and future research directions are discussed.
Inhalation Bioaccessibility and Risk Assessment of Metals in PM2.5 Based on a Multiple-Path Particle Dosimetry Model in the Smelting District of Northeast China
Authors: Sun Siyu , Zheng Na , Wang Sujing , Li Yunyang , Hou Shengnan , An Qirui , Chen Changcheng , Li Xiaoqian , Ji Yining , Li Pengyang
Published: July 2022

PM2.5 can deposit and partially dissolve in the pulmonary region. In order to be consistent with the reality of the pulmonary region and avoid overestimating the inhalation human health risk, the bioaccessibility of PM2.5 heavy metals and the deposition fraction (DF) urgently needs to be considered. This paper simulates the bioaccessibility of PM2.5 heavy metals in acidic intracellular and neutral extracellular deposition environments by simulating lung fluid. The multipath particle dosimetry model was used to simulate DF of PM2.5. According to the exposure assessment method of the U.S. Environmental Protection Agency, the inhalation exposure dose threshold was calculated, and the human health risk with different inhalation exposure doses was compared. The bioaccessibility of heavy metals is 12.1–36.2%. The total DF of PM2.5 in adults was higher than that in children, and children were higher than adults in the pulmonary region, and gradually decreased with age. The inhalation exposure dose threshold is 0.04–14.2 mg·kg−1·day−1 for the non-carcinogenic exposure dose and 0.007–0.043 mg·kg−1·day−1 for the carcinogenic exposure dose. Cd and Pb in PM2.5 in the study area have a non-carcinogenic risk to human health (hazard index < 1), and Cd has no or a potential carcinogenic risk to human health. A revised inhalation health risk assessment may avoid overestimation.
At Which Area Level Does COVID-19 Infection Matter Most for an Individual’s Self-Rated Health? A Multilevel Fixed-Effects Model Analysis in Japan
Authors: Oshio Takashi , Kimura Hiromi , Nishizaki Toshimi , Kuwahara Susumu
Published: July 2022

Several studies have reported the adverse impacts of the COVID-19 pandemic on health outcomes. However, little is known about which area of COVID-19 infection matters most for an individual’s subjective health outcomes. We addressed this issue in the present study. We used the longitudinal data of 2260 individuals obtained from a two-wave internet-based nationwide survey conducted in Japan. We estimated the multilevel regression models, which controlled for fixed effects at the individual and prefecture levels, to explain an individual’s self-rated health (SRH) based on the reported number of new COVID-19 infection cases at different area levels: prefecture, group of neighboring prefectures, and regional bloc. We found that SRH was highly associated with the average and maximum number of new infection cases among neighboring prefectures or in the regional bloc, but not with those at the prefecture level, if used jointly as explanatory variables. The results suggest that inter-prefectural coordination is needed not only to contain COVID-19 but also to reduce its adverse impact on the subjective health outcomes of residents.
Shift Work and Serum Vitamin D Levels: A Systematic Review and Meta-Analysis
Authors: Martelli Margherita , Salvio Gianmaria , Santarelli Lory , Bracci Massimo
Published: July 2022

Vitamin D deficiency and insufficiency are highly prevalent conditions worldwide due to several factors, including poor sun exposure. Shift workers may be exposed to the risk of hypovitaminosis D due to fewer opportunities for sunlight exposure compared to day workers. A systematic review of the PubMed, SCOPUS, and EMBASE databases was conducted according to the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) statement to investigate the effect of shift work on vitamin D levels. Mean differences (MD) and 95% confidence intervals (CI) of serum 25-OH-D levels in shift workers and non-shift workers were calculated. A total of 13 cross-sectional studies were included in the meta-analysis. We found significantly lower levels of serum 25-OH-D in shift workers compared with non-shift workers (MD: −1.85, 95% CI [−2.49 to −1.21]). Heterogeneity among included studies was high (I2 = 89%, p < 0.0001), and neither subgroup analysis nor meta-regression were able to identify specific sources of the heterogeneity that may be related to the different characteristics of shift work among studies. The monitoring of serum vitamin D levels and prompt correction of any deficiencies should be considered in shift workers. Notably, since a large part of the observations are derived from Koreans, larger epidemiological studies are needed in other populations.
Post Placement and Restoration of Endodontically Treated Canines: A Finite Element Analysis Study
Authors: Popescu Alexandru Dan , Popa Dragoș Laurențiu , Nicola Andreea Gabriela , Dascălu Ionela Teodora , Petcu Cristian , Tircă Tiberiu , Tuculina Mihaela Jana , Mocanu Horia , Staicu Adela Nicoleta , Gheorghiță Lelia Mihaela
Published: July 2022

The purpose of this study was to show the improved outcomes of restoring endodontically treated teeth with fiberglass posts compared to restorations using metal posts. In our study, we used the Finite Element Method (FEM), which is based on the principle that a physical model that supports a given load distributes the stress throughout its volume. We sought to assess what stress results in a tooth when it is restored using a fiberglass post compared to restoration using a metal post. The finite element analysis showed that a system consisting of a tooth with a fiberglass post is more stable in terms of the maximum stress than a system consisting of a tooth with a metal post. The maximum displacements and deformations were obtained in the case of a canine restored with a fiberglass post, which showed that this system had a high elasticity, therefore, higher strength than a canine restored with a metal post, which had high rigidity.
Vocal Behavior of Teachers Reading with Raised Voice in a Noisy Environment
Authors: Nusseck Manfred , Immerz Anna , Richter Bernhard , Traser Louisa
Published: July 2022

(1) Objective: Teaching is a particularly voice-demanding occupation. Voice training provided during teachers’ education is often insufficient and thus teachers are at risk of developing voice disorders. Vocal demands during teaching are not only characterized by speaking for long durations but also by speaking in noisy environments. This provokes the so-called Lombard effect, which intuitively leads to an increase in voice intensity, pitch and phonation time in laboratory studies. However, this effect has not been thoroughly investigated in realistic teaching scenarios. (2) Methods: This study thus examined how 13 experienced, but vocally untrained, teachers behaved when reading in a noisy compared to quiet background environment. The quiet and noisy conditions were provided by a live audience either listening quietly or making noise by talking to each other. By using a portable voice accumulator, the fundamental frequency, sound pressure level of the voice and the noise as well as the phonation time were recorded in both conditions. (3) Results: The results showed that the teachers mainly responded according to the Lombard effect. In addition, analysis of phonation time revealed that they failed to increase inhalation time and appeared to lose articulation through the shortening of voiceless consonants in the noisy condition. (4) Conclusions: The teachers demonstrated vocally demanding behavior when speaking in the noisy condition, which can lead to vocal fatigue and cause dysphonia. The findings underline the necessity for specific voice training in teachers’ education, and the content of such training is discussed in light of the results.
Can China’s Carbon Emissions Trading System Achieve the Synergistic Effect of Carbon Reduction and Pollution Control?
Authors: Chen Li , Wang Di , Shi Ruyi
Published: July 2022

Achieving synergistic governance of air pollution treatment and greenhouse gas emission reduction is the way for the Chinese government to achieve green transformational development. Against this background, this paper takes the implementation of the carbon emissions trading system (ETS) as the breakthrough point, using the time-varying difference-in-differences (DID) model to explore the synergistic emission reduction effect of ETS on air pollution and carbon emissions and its mechanism. The results indicate that the implementation of ETS not only significantly reduces CO2 emissions but also synergistically achieves the reduction of air pollutants, and the synergistic emission reduction effect is mainly achieved through the synergistic reduction of SO2. Moreover, the emission reduction effect of ETS has economic and regional heterogeneity. On the one hand, the ETS has a more prominent carbon reduction effect in less developed provinces and cities and has a significant synergistic emission reduction effect on SO2 and PM2.5; on the other hand, the carbon emission reduction effect of ETS is more potent in Beijing, Hubei, and Shanghai, followed by Tianjin and Chongqing, and the weakest in Guangdong. In addition, through the analysis of the mediating effect, this paper finds that reducing energy consumption, optimizing the energy structure, and improving energy efficiency are effective ways for ETS to achieve synergistic emission reduction. This study provides valuable policy enlightenment for promoting the synergistic governance of pollution and carbon reduction.
Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study
Authors: Watanabe Takumi , Hayashi Kyoko , Takara Tsuyoshi , Teratani Takumi , Kitayama Joji , Kawahara Toshio
Published: July 2022

Mouse studies have reported anti-stress effects of Lactiplantibacillus plantarum SNK12 (SNK). Specifically, oral SNK administration increased mRNA levels of hippocampal neurotrophic factor and gamma-aminobutyric acid receptor in mice with sub-chronic mild stress-induced social defeat; moreover, it improved depressive behavior. We aimed to evaluate the efficacy of SNK ingestion against stress in healthy adults. We used the Uchida–Kraepelin test for the stress load, with a low-dose (50 mg/day), high-dose (150 mg/day), and placebo groups (dextrin). The primary outcome was the psychological evaluation as measured by the Profile of Mood States 2nd Edition (POMS2) using total mood disturbance (TMD) scores. The secondary outcomes were the score of each POMS2 item, salivary cortisol as a stress marker, and autonomic balance with the low frequency (LF)/ high frequency (HF) ratio. Compared with the placebo group, the SNK ingestion group showed significantly lower TMD scores. Additionally, compared with the placebo group, the high-dose group showed significantly lower scores for Tension-Anxiety and Confusion-Bewilderment, while the low-dose group showed significantly lower Anger-Hostility scores, salivary cortisol levels, and LF/HF scores. Our findings suggest that SNK ingestion could relieve stress (negative feelings, anxiety, tension, embarrassment, confusion, anger, and hostility) resulting from the temporary load caused by work and study.
Perception of COVID-19 Booster Dose Vaccine among Healthcare Workers in India and Saudi Arabia
Authors: Vellappally Sajith , Naik Sachin , Alsadon Omar , Al-Kheraif Abdulaziz Abdullah , Alayadi Haya , Alsiwat Areej Jaber , Kumar Aswini , Hashem Mohamed , Varghese Nibu , Thomas Nebu George , Anil Sukumaran
Published: July 2022

Background: COVID-19 vaccines were made available to the public by the end of 2020. However, little is known about COVID-19 booster dose (CBD) vaccine perception among healthcare workers (HCW) worldwide. The present study aims to assess the perception of CBD vaccines among healthcare workers in India and Saudi Arabia (SA). Methods: A cross-sectional study was conducted among HCWs in two countries, India and SA. Data were gathered through the use of a self-administered questionnaire. A convenience sampling technique was utilized to collect the data. Results: A total of 833 HCW responses were collected from the two countries, with 530 participants from India and 303 participants from SA responding to the questionnaire. Among them, 16% from India and 33% from SA were unwilling to take a CBD (p < 0.005). The primary reasons for not being willing were concerns about whether the vaccine would be effective (32%) and concerns about probable long-term side effects (31%). Concerns about not knowing enough about the vaccination (30%) and the possibility of long-term side effects (28%) were the primary concerns in SA. Regression analysis showed that males, urban residents, and post-graduates were more willing to take the CBD. Conclusion: There is a good perception of CBD and some hesitancy in receiving the booster dose among HCWs in both countries. The introduction of personalized education, risk communication, and deliberate policy could help to reduce the number of people who are unwilling to take a booster shot.
How Does Economic Policy Uncertainty Affect Momentum Returns? Evidence from China
Authors: Zhao Peizhi , Wang Yuyan
Published: July 2022

Economic policy uncertainty has been identified as a new macroeconomic risk factor that harms the stock market’s profitability. This paper examines the impact of the Chinese EPU levels on one of the most famous financial anomalies—momentum returns. A new EPU index based on mainland China newspapers is used to obtain more accurate EPU–momentum relations. We selected 3958 Chinese listed companies’ stocks from 2011 to 2022 to establish time-series (TSM) and returns signal momentum strategies (RSM). Although the momentum effect in the Chinese stock market is weak, the EPU-based dynamic-threshold RSM strategies yield significant positive excess returns: eight times more excess returns than conventional fixed-threshold strategies. We used the ordinary least squares regression model (OLS), and the event study method only identified robust negative EPU–momentum relationships in the Chinese stock market during high-EPU stages. Surprisingly, the negative relationship between EPU and momentum returns turns positive during expansion cycles. We explain this phenomenon as follows: expansions increase Chinese investors’ confidence, and uncertainties reduce market manipulations.
An Assessment of the Accessibility of Multiple Public Service Facilities and Its Correlation with Housing Prices Using an Improved 2SFCA Method—A Case Study of Jinan City, China
Authors: Yang Luoan , Zhang Shumin , Guan Mei , Cao Jianfei , Zhang Baolei
Published: July 2022

The spatial distribution and accessibility of urban public service facilities affect socioeconomic factors in the lives of residents, especially housing prices. Given that most previous studies focus on the accessibility of a certain, single type of facility and its impact on housing prices, this research uses improved two-step floating catchment area (2SFCA) methods by considering the differences in the service capacity of different types of public service facilities in real life to evaluate their accessibility to residential communities in Jinan city based on 3117 facilities covering 11 different kinds of facilitates. Then, we assess the spatial distribution of the impact of the accessibility of different public service facilities on housing prices in Jinan city through a local indicator of a spatial association (LISA) cluster diagram generated based on the bivariate local Moran’s index. Our objectives are to assess the accessibility of multiple public service facilities using an improved 2SFCA method and to explore the spatial correlations between the accessibility of public service facilities and housing prices. The results show that the housing prices in Jinan are clustered and that the areas with high housing prices are mainly concentrated in the Lixia District and the center of the downtown area. The accessibility of medical, shopping, educational and bus stop facilities in the Lixia District is better than that in other districts. The accessibility of shopping, medical and tourist attraction facilities has the most significant impact on housing prices, and the number of communities in which the accessibility of these public service facilities and housing prices form a positive correlation cluster accounts for 50.5%, 47.9% and 45.8% of all communities, respectively. On the other hand, educational accessibility and bus stop accessibility have nothing to do with housing prices, and the number of communities in which the accessibility of these public service facilities forms a not-significant cluster with housing prices accounting for 51.1% and 56.5% of the total, respectively. In this study, the combined 2SFCA method is used to improve the method for evaluating the accessibility of a variety of public service facilities, and its applicability is verified by practical application. By analyzing the spatial correlation between accessibility and housing prices, we expand our understanding of accessibility and show that it plays a central role in housing prices, which will help to improve the spatial pattern of urban public places in the future, provide support for decision makers and provide a reference for the government and real estate developers.
How Do Transposable Elements Activate Expression of Transcriptionally Silent Antibiotic Resistance Genes?
Authors: Lipszyc Aleksander , Szuplewska Magdalena , Bartosik Dariusz
Published: July 2022

The rapidly emerging phenomenon of antibiotic resistance threatens to substantially reduce the efficacy of available antibacterial therapies. Dissemination of resistance, even between phylogenetically distant bacterial species, is mediated mainly by mobile genetic elements, considered to be natural vectors of horizontal gene transfer. Transposable elements (TEs) play a major role in this process—due to their highly recombinogenic nature they can mobilize adjacent genes and can introduce them into the pool of mobile DNA. Studies investigating this phenomenon usually focus on the genetic load of transposons and the molecular basis of their mobility. However, genes introduced into evolutionarily distant hosts are not necessarily expressed. As a result, bacterial genomes contain a reservoir of transcriptionally silent genetic information that can be activated by various transposon-related recombination events. The TEs themselves along with processes associated with their transposition can introduce promoters into random genomic locations. Thus, similarly to integrons, they have the potential to convert dormant genes into fully functional antibiotic resistance determinants. In this review, we describe the genetic basis of such events and by extension the mechanisms promoting the emergence of new drug-resistant bacterial strains.