bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Relationships between Problem-Solving Ability, Resilience and Academic Burnout in Virtual Medical Education Students Using Structural Equation Modeling
Authors: Khoshgoftar Z. , Karamali F. , Nasrabadi M.Z. , Nejad M.H.
Published: November 2023

the purpose of the present study is to investigate the relationship between academic resilience and academic burnout through the mediation of problem-solving ability.Research questionnaires (demographics, academic burnout, academic resilience and problem-solving ability) were sent online through Press Online software in 2021 for a sample size of 260 students of virtual medical education. Descriptive statistics, Pearson correlation and Structural equation modeling were used to examine the characteristics of the participants, correlation between main variable and test the study hypothesis. Based on the results the model fit indices CFI (comparative fit index), NFI (normed fit index), TLI (Tuckere Lewis index), X2/DF (the ratio of X2 to degrees of freedom) and RMSEA (Root mean of square error approximation) were appropriate. it was found that the academic burnout with problem solving skill (β = -0.77), academic resilience (β = 0.26) and problem-solving skill with academic Resilience (β = 0.96) has a statistically significant relationship. Also, it was found that most of the relationship between academic burnout and academic resilience is indirect and through the mediator variable of problem-solving skills (-0.871).The results of this research determined that there is a certain group of students suffering from burnout and weak problem-solving skills, who are at risk. Screen such students and provide them with short courses aimed at developing adaptive coping skills, such as problem solving, which can prevent their academic burnout.
Modern aspects in the treatment of intra-articular fractures and fractures of the proximal interphalangeal joints of the three-phalangeal fingers of the hand, as well as their consequences
Authors: Golubev Igor O. , Merkulov Maksim  V. , Kusnetsov Vasily  D. , Bushuev Oleg  M. , Kutepov Ilya A. , Baliura Grigoriy  G.
Published: November 2023

BACKGROUND: Proximal interphalangeal joint intra-articular fractures are a prevalent problem in traumatology and orthopedics. Damage typically develops at the base of the middle phalanx due to a collision with the head of the proximal phalanx. As a result, the fingers function declines significantly, which inevitably impacts the function of the entire brush. Compared with long-standing injuries, treating patients with this pathology in the acute period of injury is more likely to result in limb function restoration. Suppose an intra-articular fracture is underestimated or missed in the early stages. In that case, the doctor may eventually encounter chronic pain syndrome, joint and/or stiffness, and more time-consuming treatment procedures. There are many methods of treatment for both acute and long-standing injuries, each with advantages and disadvantages.
OBJECTIVE: To describe, in our opinion, the most effective modalities of therapy for patients with these injuries in the early stages (up to 4 weeks from the time of injury) and long-term periods (more than 4 weeks).
MATERIALS AND METHODS: The Suzuki external fixation spoke device (pins and rubber traction system [PRTS]) was used to treat 26 patients with fractures and dislocations of the base of the middle phalanx of the three-phalangeal fingers of the hand in the acute period of injury. Arthroplasty of the base of the middle phalanx with a hook bone graft (hemihamate) with its modifications was used in the treatment of 23 patients with inadequately fused intra-articular fractures of the base of the middle phalanx of the three-phalangeal fingers of the hand. All patients underwent physical examinations, X-rays, and/or CT scans to diagnose and confirm or clarify the nature of the damage. All patients developed passive/active movements early in the operated section during the postoperative period.
RESULTS: The patient estimated the VAS pain syndrome at 46 points on the scale; however, after 68 weeks, this indicator was 01 points. After 68 weeks, the amplitude of movements in the proximal interphalangeal joint of the fingers from the average of 3050 after 68 weeks, was reached the average of 1595. There was a 1520 extensor contracture in two patients.
CONCLUSION: The treatment of patients with intra-articular fractures and fracture-dislocations in the proximal interphalangeal joint of the three-phalangeal fingers of the hand, as well as their consequences, is a complex current problem in traumatology and orthopedics with no one-word universal solution. To select treatment strategies, a comprehensive evaluation of the patient, correct verification and interpretation of the existing damage, and a thorough understanding of the anatomy of the fingers and the hand are required.
Pneumococcal meningitis in children in Iceland – case report and summary
Authors:   Children´s Hospital, Landspitali, Reykjavik, Stensrud Jens , Óskarsson Óskar Örn ,   Children´s Hospital, Landspitali, Reykjavik, Erlendsdóttir Helga ,   Department of Clinical Microbiology, Landspitali, Reykjavik, Stefánsson Thors Valtýr ,   Children´s Hospital, Landspitali, Reykjavik, University of Iceland, Medical Division
Published: November 2023

An eleven month old girl was referred to the pediatric emergency department at Landspitali Hospital due to fever and lethargy. On examination she was acutely ill with fluctuating level of conciousness. She deteriorated quickly after arrival at the emergency department and was diagnosed with pneumococcal meningitis. In the past year several cases of bacterial meningitis have been diagnosed with Streptococcus pneumoniae as the most common pathogen. The disease causing serotypes have been serotypes that were not in the vaccine that was used in iceland and the Icelandic health authorities have decided to change the vaccination programme accordingly.
Effects of self-assessment on students’ evaluative skills: A convergent mixed-methods study at Samtse College of Education
Authors: Seden Kinley , Thomas David A. , Rinchen Sonam
Published: November 2023

Self-assessment is a beneficial practice in students’ development of evaluative judgement. In order to enhance students’ evaluative skills, a self-assessment treatment was introduced in the Economics Education I module at Samtse College of Education. The students are expected to self-assess various classroom activities and module assignments. For the students to be able to self-assess their learning, the researcher introduced specific instructional rubrics and gradation criteria to ensure quality and for students to carry out self-assessment. Using a mixed-methods design, the study examined the effects of self-assessment on students’ evaluative skills. The data were collected using a one-group pre- and post-survey questionnaire followed by open-ended responses and document analysis. The participants were 17 economics students who were purposefully selected. The key findings reveal that self-assessment, if carried out rigorously and effectively, can enhance students’ evaluative skills. The results also indicate that self-assessment action on developing students’ evaluative skills was positive and statistically significant. The study suggests the importance of involving students in the design of tasks, rubrics, and assessment criteria for developing students’ evaluative skills.
Les facteurs prosodiques dans le discours antisémite français et polonais. Sont-ils de simples expressions d’émotions ou constituent-ils de vrais arguments ?
Authors: Pirogowska Ewa
Published: November 2023

L’article présente, de façon synthétisante, quelques observations de l’auteure quant au fonctionnement des éléments prosodiques dans le discours portant sur des questions juives qui, très souvent, dégénère en discours antisémite. Le corpus est constitué d’apports discursifs puisés dans des interactions internet authentiques, focalisées sur les activités de Dieudonné M’bala M’bala en France à partir de 2009 et sur les performances de Rafal Betlejewski en Pologne à partir de 2007. Puisque ce discours se réalise dans le registre interactif écrit, il s’agit des imitations graphiques de la prosodie. On analyse des exemples des équivalents de la prononciation marquée, de l’accent sur le topic de l’énoncé, des jeux de mots résidant sur l’homonymie. L’auteure soutient que de telles imitations, outre l’expression des émotions, entrainent aussi des effets argumentatifs.
Relación entre ansiedad, depresión y linfocitos T CD4+ en pacientes con virus de inmunodeficiencia humana (VIH) en un hospital general de Lima*
Authors: Grados-Castro Diana , Huarcaya-Victoria Jeff
Published: November 2023

Objetivo: Determinar la relación entre ansiedad, depresión y recuento de linfocitos T CD4+ en una muestra de personas portadoras del virus de inmunodeficiencia humana (VIH). Metodología: Estudio observacional y analítico. Se evaluó a 144 pacientes con VIH en un hospital general de Lima, Perú. Se utilizó la Escala de Ansiedad y Depresión Hospitalaria (HADS). Resultados: La edad media de los sujetos de estudio fue de 41 años. La mayoría estuvo constituida por varones (71,5 %), solteros (86,1 %) y con grado de instrucción secundaria (57,6 %). La duración promedio de la enfermedad fue 7,7 años; el 11,1 % presentó alguna comorbilidad; y el 95,1 % utilizó tenofovir como tratamiento. El 34 % y el 16,7 % presentaron algún nivel de ansiedad y depresión, respectivamente. Los pacientes que se encontraban en estadio de sida presentaron mayores niveles de ansiedad (p < 0,001) y depresión (p < 0,001). Los pacientes con VIH y comorbilidades médicas presentaron mayores niveles de depresión (p = 0,044). Los niveles de ansiedad (ρ = –0,516, p = 0,01) y depresión (ρ = –0,509; p = 0,01) estuvieron relacionados con el recuento de linfocitos T CD4+. Conclusión: Se encontraron mayores niveles de depresión en pacientes con comorbilidades y estadio de sida, así como mayores niveles de ansiedad en pacientes en estadio de sida. Se comprobó, además, una relación indirecta y significativa entre los niveles de ansiedad, depresión y el recuento de linfocitos T CD4+. Se recomienda capacitar a los profesionales de salud en el tamizaje de ansiedad y depresión, a fin de mejorar la salud mental de pacientes con VIH.
2017-2023: state of the art of gene therapies in rare diseases in Europe: the dynamics of clinical R&D, new approved treatments and expected therapies in the pipelines
Authors: Gicquel Tristan , Cortial Lucas , Lutsyk Karyna , Forget Sylvain , Braun Serge , Boyer Pierre-Olivier , Laugel Vincent , Blin Olivier
Published: November 2023

Aim: Gene therapies have been tested over the past three decades, and after a first market authorization in 2017, the field is starting to deliver. The study aims to analyze the current development dynamics of gene therapies for rare diseases using the GENOTRIAL database®, which gathers information on gene therapy clinical trials and studies conducted between 2017 and 2023 in Europe.

Methods: The study involved extracting and filtering clinical trial data from the EudraCT database. Trials with the keyword "Gene Therapy" were selected and filtered using the "Rare disease" filter. Manual verification was conducted to ensure that the selected trial only concerned gene therapy treatments authorized in Europe for rare diseases in phases I to III. A total of 300 European country-related clinical investigations representing a total of 93 European-specific clinical studies were included in the GENOTRIAL database. The trials were classified by development phases, temporal status, sponsors and investigating countries, rare diseases with their related therapeutic area, and approval regulatory information of the identified gene therapies.

Results: Analysis reveals that rare diseases present a promising area for gene therapy development. On average, eight rare disease gene therapy trials are launched each year in Europe. The main sponsors of European clinical trials of gene therapies for rare diseases are from US, followed by the United Kingdom and France. The United Kingdom conducts the highest number of investigations in Europe, followed by France, Italy, Spain, and Germany. Nutritional and metabolic diseases are the most represented therapeutic area, followed by rare oncology, blood and lymphatic diseases, and ocular diseases. The analysis identifies 73 gene therapy medical products covering 35 diseases at various stages of development, with 12 new therapies approved in recent years for 8 rare diseases, while 15 other gene therapies are at an advanced stage of phase III in their development plan for 11 other rare diseases.

Conclusion: Gene therapy has shown significant progress and potential in treating rare genetic diseases. Europe has emerged as a promising region for gene therapy clinical trials in rare diseases. Efforts are now required to catch up with the USA and UK regarding the number of clinical trials sponsored by European groups.
Liquid metals nanotransformer for healthcare biosensors
Authors: Bai Yunlong , Zhang Jie , Lu Chennan , Rao Wei
Published: November 2023

Featuring low cost, low melting points, excellent biocompatibility, outstanding electrical conductivity, and mechanical properties, gallium-based liquid metals (LMs) have become a promising class of materials to fabricate flexible healthcare sensors. However, the extremely high surface tension hinders their manipulation and cooperation with substrates. To address this problem, the inspiration of nanomaterials has been adopted to mold LMs into LM nanoparticles (LMNPs) with expanded advantages. The transformability of LMNPs endows them with functionalities for sensors in multiple dimensions, such as intelligent response to specific molecules or strains, various morphologies, integration into high-resolution circuits, and conductive elastomers. This review aims to summarize the superior properties of LMs, transformability of LMNPs, and correlated advantages for sensor performance. Multidimensional functional sensing forms consisting of LMNPs and corresponding applications as healthcare sensors will be presented. In the end, the existing challenges and prospects in the processing and application of LMNPs will also be discussed.
ДОМІНАНТИ ЦИФРОВОЇ ТРАНСФОРМАЦІЇ ЕКОНОМІЧНОЇ ДІЯЛЬНОСТІ ПРОМИСЛОВИХ ПІДПРИЄМСТВ
Authors: Бояринова К.О. , Cаченко А.О.
Published: November 2023

У статті обґрунтовано, що в умовах становлення четвертої та п’ятої індустріальної революції, цифрова трансформація промислових підприємств формує основу їх подальшого розвитку. Розглянуто та узагальнено понятійний апарат: «цифрова економіка», «цифровізація», «цифрова трансформація». Визначено домінанти цифрової трансформації економічної діяльності промислових підприємств. Перша з них – адаптація економічної діяльності таких підприємств до умов функціонування в цифровій економіці. Зазначена домінанти має враховувати зміну ролі робітників промислових підприємств в системі виробництва, застосування цифрових технологій в аналітиці та прийнятті економічних рішень, використання нематеріальних факторів виробництва в економічній діяльності, застосування трьох комунікаційних середовищ цифрового економічного простору: 1) внутрішнє середовище, засноване на взаємодії елементів виробничої системи на рівнях: персонал-устаткування, устаткування-устаткування; 2) взаємодія в мережі Інтернет щодо торгівлі товарами; 3) середовище співпраці в розробленні нових продуктів чи продуктів на замовлення шляхом краудсорсингу. Другою домінантою визначено цифровізацію економічних та виробничих процесів, що передбачає впровадження промисловими підприємствами діджитал технологій, пов’язаних з предикативною аналітикою, управлінням виробництвом та життєвим циклом продукту, цифрових технологій проектування, розробки і удосконалення продуктів, а також ряду інформаційних технологій, які забезпечують економічну складову діяльності підприємств (взаємодію з постачальниками, партнерами, продажі, аналіз ринків, платіжні системи і т. ін.). Обґрунтовано третю домінанту цифрової трансформації економічної діяльності промислових підприємств – процеси цифрової трансформації, які базуються на зміні способу діяльності виробничо-економічної системи, цифровізації бізнес-процесів та зміні бізнес-моделі перенесенням економічних взаємодій у цифровий простір, формуванням ціннісної пропозиції шляхом застосування цифрових технологій виробництва, введення у ключові напрями діяльності цифровізації логістичних операцій, контролю запасів тощо.
Exploring innovative strategies to improve perinatal mental health in Scotland: co-development of an action research agenda with women, families and practitioners
Authors:   University of Dundee, Biazus-Dalcin Camila , Cumming Sara ,   University of Dundee, Farre Albert ,   University of Dundee, Gray Nicola M. ,   University of Dundee, Gavine Anna ,   University of Dundee, Rogowsky Rayna ,   University of Dundee, McFadden Alison ,   University of Dundee, Adams Rosey ,   PNDandMe, Daly Maura ,   University of Dundee, Smith Mark ,   University of Dundee, Hardee Erin ,   University of Dundee
Published: November 2023

Perinatal mental health (PNMH) is an ongoing concern for women and families, as well as for health and social care services. It is estimated that 10-20% of women will experience mental health issues and up to 10% of fathers may also experience difficulties with their mental health. This issue was recently highlighted by national media. Our previous stakeholder consultation work identified service gaps for women in the mild-moderate category of PNMH. This project aimed to explore this identified gap further by bringing together a diverse group of partners, including women/families, practitioners and researchers to co-develop a collaborative action-research agenda. Project design and delivery was developed in collaboration with an expert with lived experience to ensure all elements were relevant and relatable. It is crucial to involve all stakeholders, including those with lived experience and practitioners, in discussions regarding successful interventions for perinatal mental health. This approach ensures that families receive better outcomes in a sustainable and scalable manner.
APPROACH TO REDUCING THE NUMBER OF TECHNOLOGICAL TRANSITIONS IN THE PRODUCTION OF BENT PROFILES
Authors: Saienko Oleksii , Hubskyi Serhii , Chukhlib Vitaliy , Sergienko Nikolay , Kolisnyk Kostiantyn
Published: November 2023

The article provides a generalized overview of approaches to reducing the number of technological transitions when reducing the production of bent profiles. In particular, various methods of producing bent profiles are considered, taking into account the requirements for the final product. The calculation of calibration of the production of trough profiles according to two calibration schemes has been developed. This calculation allows for an efficient production process of bent profiles and helps to reduce the number of technological transitions required to achieve the desired result. The production of a trough profile was modeled and graphs illustrating the profile manufacturing process were created. This made it possible to visualize various aspects of the technological process and find out which methods and calibration schemes are most effective for achieving the goal. Based on the data obtained, reasonable conclusions were drawn. These conclusions indicate which approaches and methods for producing bent profiles are optimal when reducing the number of process transitions. The results of the study can be useful for industrial enterprises engaged in the production of bent profiles, helping them to choose the most effective methods and calibration schemes to improve the production process and reduce costs.
PENERAPAN DIGITAL BOOK SEBAGAI MODUL PEMBELAJARAN PADA MATA KULIAH KONSTRUKSI BANGUNAN I PENDIDIKAN TEKNIK BANGUNAN FAKULTAS TEKNIK UNIVERSITAS NEGERI JAKARTA
Authors: Firdaus Yusuf , Daryati  , Saleh Rosmawita
Published: November 2023

This research departs from the problems that occur in the field, currently there are still many lecturers who have not used a variety of learning media, and according to the characteristics and needs of students in line with technological and IT developments. This study aims to find out how the application of the e-Learning Module learning media using E-Books as an interactive learning medium in the Building Construction 1 Course in the Building Engineering Education Study Program, UNJ, and its feasibility as an interactive learning medium in the Building Construction 1 Course in the Education Study Program. Building Engineering, UNJ. The research is using qualitative methods with the model of definition, design, and implementation. The research subjects were 2 lecturers and 63 students from the 2018-2019 class. The analysis used is descriptive analysis. The results of the study concluded that: (1) the application of the e-Learning Module learning media using E-Books as interactive learning media in the Building Construction I course at the Building Engineering Education Study Program, UNJ Jakarta was considered effective with a practical student percentage of 81.11% including the category very effective, especially used as online learning, and (2) the e-Learning module uses E-Books as interactive learning media in the Building Construction Course I at the Building Engineering Education Study Program, UNJ Jakarta which is very practical and feasible as an interactive learning medium in Building Construction I course at the Building Engineering Education Study Program, UNJ Jakarta, both based on the content of the material (88.50%), or based on the media aspect (83.33%), especially in online learning.
Twitter: una herramienta auxiliar en la docencia del derecho Constitucional.
Authors: López Rubio Daniel
Published: November 2023

Twitter es una red de microblogging surgida en 2006 y que emplean a diariomillones de personas. En los últimos tiempos se ha convertido en un sistema decomunicación sin cuya consideración es imposible explicar la realidad de muchosprocesos políticos. Desde esta perspectiva, el trabajo analiza las bondades quepuede ofrecer el empleo de esta herramienta como mecanismo auxiliar en ladocencia del Derecho Constitucional. Muchas instituciones públicas, así como elgrueso de autoridades y líderes políticos, cuentan con un perfil en Twitter desde elque ofrecen información diversa. Así, en una disciplina como el DerechoConstitucional, centrada en el estudio de la organización y funcionamiento de lospoderes públicos e instituciones nucleares del Estado, la importancia política deesta red social puede convertirla en un ámbito idóneo para la mejor ilustración desus aspectos prácticos.
Cómo aproximar el Derecho Constitucional a alumnos de Grados no jurídicos.
Authors: Pérez Conchillo Eloisa , Martínez Quevedo Luis Fernando
Published: November 2023

Es frecuente la presencia de asignaturas propias del Derecho constitucional enGrados cuya formación no es estrictamente jurídica. A menudo, los estudiantes muestrancierta dificultad para el manejo de categorías y términos propios del Derecho en generaly del Derecho constitucional en particular, aunque ambos tengan cierta relevancia en lavida cotidiana de las personas. El objetivo de este trabajo es plantear actividades quecomplementen las clases magistrales, a través de una metodología en la que el alumnosea protagonista, mediante las cuales puedan tomar conciencia de la habitualidad delDerecho constitucional en la realidad y, simultáneamente, desarrollar habilidades ydestrezas que puedan servirles en su futuro laboral.
EL USO DE “PRUEBAS DE CLASE” COMO HERRAMIENTA DE MOTIVACIÓN PARA EL APRENDIZAJE. UNA EXPERIENCIA PARA ASIGNATURAS DE DERECHO
Authors: Bueno Armijo Antonio M. , Magaldi Mendaña Nuria
Published: November 2023

El profesor puede influir (positiva y negativamente) en la motivación para el aprendizaje del alumno. La realización de pequeñas pruebas de clase, que fuercen al alumno a llevar la asignatura al día, podría disminuir la percepción del esfuerzo exigido por el examen final, incidiendo favorablemente en la motivación del alumno para afrontarlo.
Mesozoic-Cenozoic Exhumation Processes of the Harlik Mountain (East Tianshan), NW China: Evidence from Apatite (U-Th)/He Thermochronology
Authors: Zhang Bin , Yang Jing , Yang Li , Chen Hong , Liu Jiaqi , Wang Fei , Wu Lin
Published: November 2023

The Tianshan Mountains, which formed through the prolonged and complex subduction-accretion of the paleo-Asian ocean, experienced multiple widespread erosions and reactivations during the Mesozoic-Cenozoic period. Thus, the Tianshan has become a crucial area to explore the process and mechanism of intracontinental orogeny. The Harlik Mountain located in the easternmost part of Tianshan has special significance in revealing crustal deformation and far-field stress propagation. In this study, we use the apatite (U-Th)/He method to investigate the near-surface exhumation process of Harlik Mountain, which is the result of tectonic events and erosion. The apatite (U-Th)/He data and thermal history modeling reveal three enhanced exhumation events in the Harlik Mountain, i.e., the early Cretaceous, the late Cretaceous-Paleocene, and the middle Eocene. These events are consistent with the exhumation patterns observed throughout the entire Tianshan. Notably, the exhumation rate and amplitude in the early Cenozoic period were significantly higher in the Harlik Mountain compared with the Mesozoic period. Our findings reveal that the exhumation of the Harlik Mountain and the entire Tianshan displayed pronounced spatial-temporal variations throughout the Mesozoic-Cenozoic period. These variations can be attributed to the combined effect of uneven northward compression of the southern Asian margin, the heterogeneous rheological properties of the lithosphere, and the complex structure of the Tianshan.
Residents’ perceptions of the pedagogical preparation of preceptors in the Brazilian Unified Health System (BUHS) and associated factors
Authors: Silva Caroline Altes Moraes da , Rutkoski Audrey Oliveira , Oliveira Diógenes Dias , Figueiredo Maria Renita Burg , Bavaresco Caren Serra , Hernandez Pedro Antonio Gonzales , de Moura Flávio Renato Reis
Published: November 2023

Preceptors are workers in the Brazilian Unified Health System (SUS) and perform the function of mediators of teaching in service to graduate students. This research study examines the residents’ perceptions of the pedagogical preparation of preceptors in the SUS and associated factors. We conducted a cross-sectional study with data collected via an online self-report questionnaire. Poisson regression with robust variance was used in multivariate analysis. Of 151 residents, 59 (39.1%) considered the preceptor to be pedagogically prepared (PPP). Recognizing the preceptor as an important actor for establishing the connection between theoretical knowledge and practice (vs unimportant) and the preceptor holding meetings for planning, monitoring, and evaluation of the proposed actions during the teaching-learning process (vs not holding) increased by 41% (PR 1.41; 95% CI, 1.33–1.50) and 33% (PR 1.33; 95% CI, 1.20–1.47), respectively, the likelihood of residents considering the PPP. Performing activities to manage the work process in the primary health care unit and implementing an intervention project in the unit under the supervision of preceptors increased by 18% (PR 1.18; 95% CI, 1.05–1.32) and 13% (PR 1.13; 95% CI, 1.01–1.27), respectively, the likelihood of residents considering the PPP compared with not performing the proposed activities. These findings are essential to align interprofessional education with education guidelines and public health policies in Brazil. Also, our results can provide useful information for the development of pedagogical guidelines for Multiprofessional Residency Programs in Brazil and in other low- and middle-income countries.
Duskward displacement of plasmoids and reconnection in the magnetotail
Authors: Ieda Akimasa , Miyashita Yukinaga
Published: November 2023

Magnetic reconnection in the near-Earth magnetotail is responsible for explosive releases of energy during auroral breakups. This near-tail reconnection was previously assumed to occur around the midnight meridian, where earthward flows were observed. The Geotail spacecraft mission discovered that the reconnection location was displaced toward dusk, based on observations of tailward-moving plasmoids. This dusk preference is possibly caused by the Hall electric field, as was suggested in recent simulations. However, recent spacecraft observations suggested that the reconnection was displaced towards dawn, not dusk, in Mercury’s magnetotail. The reason for the difference between Earth and Mercury remains unclear. This study reinterprets and integrates previous statistical results on the dawn–dusk location of fast plasma flows in the near-Earth magnetotail to address the controversy surrounding the dawn–dusk displacement of reconnection location. Consequently, we confirmed that dusk preference is generally evident for tailward-moving structures but found that location preference is variable between studies of earthward-moving structures. These results indicate that the statistical results of earthward flows are sensitive to event selection criteria. We conclude that the dawn–dusk location of earthward flow is statistically unclear at the time of substorm onset. Accordingly, reconnection does not necessarily occur on the meridian where planetward-moving structures are observed. Tailward-moving plasmoids and reconnection may be predominantly located on the dusk side also in the Mercury’s magnetotail.
Application of Fuzzy - NSGA-II for achieving maximum biodiesel yield from waste cooking oil
Authors: Kavalli Kiran , Hebbar Gurumoorthy S , Rout Amruta
Published: November 2023

The main objective of this study was to optimize the parameters necessary for biodiesel production from waste cooking oil (WCO) using fuzzy modeling and Non-Dominated Sorting Genetic Algorithm-II (NSGA-II). To establish the relationship between input parameters (methanol, temperature, reaction time, and catalyst concentration) and the output (biodiesel yield), a fuzzy inference system was utilized. The input variables were normalized and represented by linguistic variables such as "small," "moderate," and "large," while the biodiesel yield was expressed in linguistic variables such as "small," "moderate," "moderately large," and "large." The defuzzification process was employed to obtain crisp values of the predicted output using the Centre of Gravity method, resulting in a mathematical model. This mathematical model was then used as an input function in NSGA-II to determine the optimal input process variables. NSGA-II was selected as it is a versatile and efficient metaheuristic algorithm that incorporates non-dominated sorting, accelerated strategies, and does not require sharing parameters. The developed model exhibited a high R square value of 96.34%, indicating a strong relationship between the input and output variables. The optimal transesterification process for biodiesel production from WCO was determined to be a methanol quantity of 150ml, reaction temperature of 62°C, reaction time of 63 minutes, and catalyst concentration of 7.5 grams. This optimized process yielded a conversion efficiency of 97.36%. Additionally, further experimentation was conducted using the Box-Behnken experimental design method to explore a wider range of input combinations. The maximum combination of input variables resulted in a biodiesel yield of 96.88%. Both the predicted and experimental biodiesel yields met the ASTM standard, with a conversion efficiency exceeding 96.5%. Overall, this study successfully optimized the biodiesel production process from waste cooking oil by employing fuzzy modeling and NSGA-II, leading to high conversion efficiencies and meeting industry standards.
Evaluation of risk factors for thrombosis after ultrasound-guided internal jugular vein catheterization in patients with lymphoma
Authors: Cao Kunpeng , Wang Xinyue , Wu Liuxi , Deng Hongyan , Xu Chaoli , Li Lu , Ye XinHua
Published: November 2023

We conducted a retrospective analysis of clinical and ultrasound data from 112 lymphoma patients who underwent ultrasound-guided internal jugular vein catheterization to investigate the risk factors for venous thrombosis. The procedure, which is safe and convenient for long-term chemotherapy, can be compromised by the development of venous thrombosis, impacting patient quality of life. Patients were divided into two groups: those with thrombosis (thrombus group) and those without (no thrombus group), based on preoperative vascular ultrasound findings within the internal jugular vein. In the multiple logistic regression analysis models, the catheter diameter (OR=0.145, 95%CI: 0.032-0.660, P<0.05), FIB (OR=2.438, 95%CI: 1.306-4.552, P<0.05), and diabetes (OR=0.139, 95%CI: 0.026-0.754, P<0.05) were found to have independent associations with thrombosis in lymphoma patients who underwent ultrasound-guided internal jugular vein catheterization (all P<0.05). The area under the curve was 0.816, indicating good predictive accuracy of the nomogram model for assessing the risk of thrombosis.
Temporal dynamics of wheat blast caused by Pyricularia oryzae Triticum lineage throughout the successive wheat cycles
Authors: Dorigan Adriano Francis , Pozza Edson Ampélio , Pereira Renata Cristina Martins , Moreira Silvino Intra , Ceresini Paulo Cezar , Silva Humberson Rocha , Alves Eduardo
Published: November 2023

Wheat blast, caused by Pyricularia oryzae Triticum lineage (PoTl), can infect wheat leaves and heads. The pathogen biology and disease epidemiology of the isolates PoTl still need more profound insights for the integrated management of wheat blast in Brazilian wheat fields. This study aimed to characterize the incubation period, latent period, and the temporal progress of wheat blast and to fit the best nonlinear model, describing the nature of an epidemic of the PoTl isolate 12.1.146 compared with the PoTl isolate Py6038, throughout five successive infection cycles of PoTl on wheat leaves and heads. Wheat blast occurred in all infection cycles. The incubation period and latent period of the PoTl isolate 12.1.146 were significantly shorter than that of the PoTl isolate Py6038. The secondary inocula produced by the PoTl isolates on symptomatic wheat leaves caused blast symptoms when inoculated on wheat heads. The area under the disease progress curve (AUDPC) was calculated based on disease severity. In all infection cycles, the AUDPC of the PoTl isolate 12.1.146 was significantly higher than that of the PoTl isolate Py6038. The nonlinear logistic model had the best fit to describe the intensity of the disease progress curves (DPCs) of PoTl isolates on wheat leaves and heads, fitting classic sigmoid-shaped curves. Our findings show that the disease severity of the PoTl isolate 12.1.146 did not reduce under grow chamber conditions, even after five successive infection cycles. These findings may imply the integrated management of the disease wheat blast pathogen in Brazilian fields.
A precision medicine approach to coronary artery disease risk prediction and mitigation in people with type 2 diabetes
Authors: Franks Paul , Coral Daniel , Fernández-Tajes Juan , Pigeyre Marie , Chong Michael , Atabaki-Pasdar Naeimeh , Fitipaldi Hugo , Kalamajski Sebastian , Gomez Maria , Paré Guillaume , Giordano Giuseppe , Pearson Ewan
Published: November 2023

Type 2 diabetes (T2D) predisposes to cardiovascular disease (CVD), but it is still unclear why some individuals with T2D are at disproportionately higher or lower risk. In this study, we employed a genetic stratification method to investigate the main clinical features that differ between two diabetogenic profiles associated concordantly with susceptibility for CVD or discordantly with protection against CVD. Quantifying concordant and discordant genetic predispositions improved CVD risk prediction, especially in men, correctly reassigning higher predicted risk to 5.4% of new male cases of MACE in UK Biobank. Moreover, higher genetically determined discordance reduced the risk associated with MACE in men. In-depth comparisons across a wide spectrum of phenotypes uncovered significant disparities between these two profiles. Subsequent causal inference analyses highlighted critical features of very-low-density lipoprotein particles influencing the discordance between T2D and CVD. We prioritized 8 distinct discordant genomic loci with potential protective effects traits against CVD in individuals with T2D. These findings provide clinically relevant valuable insights for personalized approaches to prevent and treat CVD in individuals with T2D.
How Intercity Expressway Passenger Flow Varies? A View from Month, City Characteristics, and Weather at the Origin and Destination
Authors: Li Xiaowei , Shi Lanxin , Wu Chenyang
Published: November 2023

This study aims to investigate the impact factors on intercity expressway passenger flow in China. A large-scale data set that integrated multiple data sources, including intercity passenger flow, city characteristics, and weather data, were constructed. To effectively handle and identify hidden patterns in the large-scale data, we employed Explainable Artificial Intelligence (XAI) models to analyze the associations between the impact factors and the intercity expressway passenger flow. The results show that among the XAI models used, the Explainable Extra Tree model that utilized SHAP (SHapley Additive exPlanations) values to explain the contributions of impact factors outperforms all others. In terms of the impact factors, we find that the intercity expressway passenger flow increased remarkably during certain months (such as February and September). In addition to city characteristics and weather variables that have been investigated by previous studies (e.g., GDP and temperature), the male-female ratio, the city tiers, and the temperature at the origin and destination cities were also found to be important contributors to expressway passenger flow. This study contributes to a deeper understanding of intercity expressway passenger flow patterns, offering valuable insights to policymakers for more effective management of intercity expressway passenger transportation.
Potential Role of Peripheral Blood Lymphocyte Subsets in Rheumatoid Arthritis Patients Concurrent with Hepatitis B Virus Infection：A Retrospective Cohort Study
Authors: Lijia Shao , Shuo Zhao , Shengchun Feng , Yongjun Ma , Lihong Shen
Published: November 2023

Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Previous studies have shown that RA patients have high HBV infection rates. Hepatitis B virus (HBV) infection has a deleterious effect on the radiographic and clinical outcomes of patients with RA. This study investigated the composition of peripheral blood lymphocytes in patients with RA and concurrent HBV infection. Identifying peripheral blood lymphocyte subsets could provide insights into their deleterious effects on clinical outcomes among these patients. Methods To investigate the composition of peripheral blood lymphocytes in patients with RA or RA with concurrent HBV infection, 298 patients were recruited from a prospective cohort of patients with RA. Based on the HBV infection status, 43 patients with RA and concurrent HBV infection were assigned to the HBV group (HBV-RA group), while 255 patients without HBV infection were assigned to the control group. Patients in the HBV-RA group were split into groups with HBV DNA levels below the lower limit of quantification (< 20 IU/ml, HBV DNAlowgroup) and above the lower limit of quantification (≥ 20 IU/ml, HBV DNAhighgroup). Demographic, clinical, and laboratory data were also collected. Results Compared with those of the control group, a higher percentage of CD19+B cells and CD8+T cells and a lower CD4+/CD8+ratio were observed in the HBV-RA group (allP < 0.05). The same trend was observed in the HBV DNAhighgroup compared to the HBV DNAlowgroup (allP < 0.05). In addition, according to multivariable logistic regression analysis, male sex, DAS-28 ≥ 2.6, and a high proportion of CD19+B and CD8+T cells were unfavorable factors for HBV-infected RA (allP < 0.05). Conclusion The composition of peripheral blood lymphocytes in patients with RA and concurrent HBV infection differs from that of patients with RA without HBV infection. Male sex, DAS-28 ≥ 2.6, the high proportion of CD19+B and CD8+T cells were unfavorable factors for RA concurrent with HBV infection; therefore, these factors warrant greater clinical attention.
Optimizing SH-SY5Y Cell Culture: Exploring the Beneficial Effects of an Alternative Media Supplement on Cell Proliferation and Viability
Authors: Kaya Zeynep Bengisu , Santiago-Padilla Valeria , Lim Melina , Boschen Suelen L. , Atilla Pergin , McLean Pamela J.
Published: November 2023

In the quest to unravel the mysteries of neurological diseases, comprehending the underlying mechanisms is supreme. The SH-SY5Y human neuroblastoma cell line serves as a crucial tool in this endeavor; however, the cells are known for its sensitivity and slow proliferation rates. Typically, this cell line is cultured with 10% Fetal Bovine Serum (FBS) supplement. Nu-Serum (NuS), a low-protein alternative to FBS, is promising to advance cell culture practices. Herein, we evaluated the substitution of NuS for FBS to test the hypothesis that an alternative serum supplement can aid and promote SH-SY5Y cell proliferation and differentiation. Our findings revealed that the NuS-supplemented group exhibited a notable increase in adhered cells compared to both the FBS and serum-free (SF) groups. Importantly, cell viability remained high in both sera treated groups, with the NuS-supplemented cells displaying significantly larger cell sizes compared to the SF-treated group. Furthermore, cell proliferation rates were higher in the NuS-treated group, and neuroblast-like morphology was observed earlier than FBS group. Notably, both FBS and NuS supported the differentiation of these cells into mature neurons. Our data supports NuS as an alternative for SH-SY5Y cell culture, with the potential to elevate the quality of research in the neuroscience field.
Exploratory Analysis of the Variable Response to an Intensive Lifestyle Change Program for Metabolic Syndrome
Authors: Maitland Scott B. , Brauer Paula , Mutch David M. , Royall Dawna , Klein Doug , Tremblay Angelo , Rheaume Caroline , Jeejeebhoy Khursheed
Published: November 2023

Background
Wide variability in response to lifestyle interventions has been recognized for many years, and researchers have begun to disentangle sources of error from inherent differences in individual responsiveness. The objective of this secondary analysis of an intensive lifestyle intervention (diet and exercise) for metabolic syndrome (MetS) was to identify potentially important differences among study completers grouped by treatment response as measured by change in a continuous metabolic syndrome (Gurka/MetS) score.
Methods
All study completers from a 12-month primary care study were categorized into one of five groups according to change in the Gurka/MetS score. A change of 0.4 in z-score defined clinically relevant change in line with results of previous studies. Repeated measures analysis of covariance was used to examine the Gurka/MetS score over 12 months, looking for differences in response over time by the five groups.
Results
Of 176 participants, 50% (n = 88) had stable scores, 10% (n = 18) had relevant change scores in the first 3 months only and reverted toward baseline, 20% (n = 35) achieved meaningful change over the whole study, 11% (n = 20) had a delayed response at 3–12 months, and 9% (n = 15) demonstrated worsening scores. Significant response group*time differences were noted (p < 0.001). Improvement in diet quality and fitness scores were similar across all groups. Available other variables did not account for the differences.
Conclusion
Work is needed to identify key factors that account for differences in responses to lifestyle interventions that can be used to guide treatment decisions for intensive lifestyle interventions for this common condition.
Trial Registration
ClinicalTrials.gov Identifier: NCT01616563; first registered June 12, 2012.
Quantum nature of ionic surfactant micelles – alternative view on micellization process
Authors: Zuev Yuriy , Zueva Olga
Published: November 2023

We developed an alternative model of ionic surfactant micellization, in which self-assembly processes have been analyzed qualitatively from point of view different from the classical one using quantum mechanics principles, symmetry considerations, together with theory of self-organization in nonequilibrium systems, accounting the probabilistic nature of processes at nanoscale and their potential quantum coherence. As a result, we declare that micelle is organized as layered fullerene-like structure with a cavity in micelle center, having solid-like properties in radial direction and liquid-like in perpendicular ones and permitting water penetration between head and upper methylene groups of surfactant ions. It was indicated that there is the exchange interaction inside micelle, which leads to socialization of electrons and their transition to the state of quantum coherence. It has been found that indispensable condition for existence of spherical micelles is synchronous radial oscillations of atoms ("breathing" of micellar particle) generating coherent elastic waves and oscillations of coherent electrons, which can be a source of electromagnetic waves with frequencies close to thermal vibration frequencies of atoms. It was shown that long-range correlations connected with radiation and leading to permanently ongoing surfactant self-assembly and disintegration makes micellar solution kinetically nonequilibrium at nanoscale and thermodynamically stable at macroscale.
Decoding Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Journey Through Unilateral Cystic Pulmonary Manifestations—A Rare Case and Literature Review
Authors: Li Ping , Huang Zhisheng , Qin Yan , Liao Wenjiao , Xiang Tianxin
Published: November 2023

We presented an atypical case of a 62-year-old female diagnosed with pulmonary Mucosa-Associated Lymphoid Tissue (p-MALT) lymphoma, uniquely manifesting as a singular cystic lesion in the lung. Diagnostic evaluations, including comprehensive imaging, bronchoscopy, and CT-guided lung biopsy, revealed this uncommon radiological presentation. Detailed histopathological and immunohistochemical assessments further cemented the diagnosis. To determine the disease's extent, systemic evaluations such as whole-body PET-CT, gastroscopy, colonoscopy, and bone marrow biopsy were conducted, confirming its localized nature. Following the definitive diagnosis, the patient underwent a Rituximab-centric therapeutic regimen, yielding significant clinical improvement. This case accentuates the importance of recognizing distinctive cystic lung features in p-MALT lymphoma and the indispensable role of holistic diagnostic approaches in guiding precise therapeutic and prognostic decisions.