bluuebunny/crossref_metadata_2025 huggingface dataset:
Mesenchymal Stromal Cells (MSCs): An Ally of B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells in Disease Maintenance and Progression within the Bone Marrow Hematopoietic Niche
Authors: Fallati Alessandra , Di Marzo Noemi , D’Amico Giovanna , Dander Erica
Published: July 2022

Mesenchymal stromal cells (MSCs) are structural components of the bone marrow (BM) niche, where they functionally interact with hematopoietic stem cells and more differentiated progenitors, contributing to hematopoiesis regulation. A growing body of evidence is nowadays pointing to a further crucial contribution of MSCs to malignant hematopoiesis. In the context of B-cell acute lymphoblastic leukemia (B-ALL), MSCs can play a pivotal role in the definition of a leukemia-supportive microenvironment, impacting on disease pathogenesis at different steps including onset, maintenance and progression. B-ALL cells hijack the BM microenvironment, including MSCs residing in the BM niche, which in turn shelter leukemic cells and protect them from chemotherapeutic agents through different mechanisms. Evidence is now arising that altered MSCs can become precious allies to leukemic cells by providing nutrients, cytokines, pro-survivals signals and exchanging organelles, as hereafter reviewed. The study of the mechanisms exploited by MSCs to nurture and protect B-ALL blasts can be instrumental in finding new druggable candidates to target the leukemic BM microenvironment. Some of these microenvironment-targeting strategies are already in preclinical or clinical experimentation, and if coupled with leukemia-directed therapies, could represent a valuable option to improve the prognosis of relapsed/refractory patients, whose management represents an unmet medical need.
Net Survival in Survival Analyses for Patients with Cancer: A Scoping Review
Authors: Nagamine Camila Macedo Lima , de Goulart Bárbara Niegia Garcia , Ziegelmann Patrícia Klarmann
Published: July 2022

Population-based net survival is an important tool for assessing prognostic advances. The unbiased Pohar Perme Estimator (PPE) was suggested in 2012 and soon established itself as the gold standard for estimating net survival. This scoping review aims to know in which context this estimator is being used in the oncology area, what the authors point out as a justification for its use, and the limitations found. We searched PubMed, and the grey literature to answer the question: Have studies involving patients diagnosed with cancer used the PPE to estimate cancer-specific survival? How do they justify the use of the PPE and what are the limitations pointed out? Out of 295 screened, 85 studies were included in this review. The two main characteristics of the PPE mentioned by the studies as justification were the fact that it is an unbiased estimator (83.5%) and that it produces comparable estimates among populations with different mortality rates from causes other than cancer (36.47%). No study pointed to a limitation due to the use of PPE. As a conclusion, the Pohar Perme Estimator is the gold standard for estimating net survival and should be more used in oncology, especially when dealing with population-based studies where the follow-up time is long, making high the probability of death from causes other than cancer.
Monitoring of Measurable Residual Disease Using Circulating DNA after Allogeneic Hematopoietic Cell Transplantation
Authors: Waterhouse Miguel , Pennisi Sandra , Pfeifer Dietmar , Scherer Florian , Zeiser Robert , Duyster Justus , Bertz Hartmut , Finke Jürgen , Duque-Afonso Jesús
Published: July 2022

Relapse of the underlying disease is a frequent complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we describe the clinical utility of measurable residual disease (MRD) and mixed chimerism (MC) assessment in circulating cell-free DNA (cfDNA) analysis to detect earlier relapse in patients with hematological malignancies after allo-HSCT. A total of 326 plasma and peripheral blood mononuclear cell (PBMCs) samples obtained from 62 patients with myeloid malignancies were analyzed by droplet-digital PCR (median follow-up: 827 days). Comparison of MC in patients at relapse and in complete remission identified an optimal discriminating threshold of 18% of recipient-derived cfDNA. After performing a targeted next-generation sequencing (NGS) panel, 136 mutations in 58 patients were detected. In a total of 119 paired samples, the putative mutations were detected in both cfDNA and PBMCs in 73 samples (61.3%). In 45 samples (37.8%) they were detected only in cfDNA, and in only one patient (0.9%) were they detected solely in DNA from PBMCs. Hence, in 6 out of 23 patients (26%) with relapse after allo-HSCT, MRD positivity was detected earlier in cfDNA (mean 397 days) than in DNA derived from PBMCs (mean 451 days). In summary, monitoring of MRD and MC in cfDNA might be useful for earlier relapse detection in patients with myeloid malignancies after allo-HSCT.
Physical Fitness and Frailty in Males after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Long-Term Follow-Up Study
Authors: Suominen Anu , Haavisto Anu , Mathiesen Sidsel , Mejdahl Nielsen Malene , Lähteenmäki Päivi M. , Sørensen Kaspar , Ifversen Marianne , Mølgaard Christian , Juul Anders , Müller Klaus , Jahnukainen Kirsi
Published: July 2022

Purpose and methods: To analyze physical fitness, physical activity and the prevalence of frailty in male long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation (HSCT). We performed a Nordic two-center study of 98 male survivors (mean age 28.7 years, range 18.5–47.0) treated with pediatric allogeneic hematopoietic stem cell transplantation (HSCT) 1980–2010 in denmark or finland. physical fitness was evaluated by the dominant hand grip-strength, timed up-and-go, sit-to-stand, gait speed and two-minute walk tests. Results: Survivors presented significantly lower muscle strength and muscle endurance in the dominant hand-grip strength (median Z-score −0.7, range −4.3–3.9) and sit-to-stand tests (median Z-score −1.5, range −3.5–2.5) compared to age and sex matched normative values of the tests. However, mobility and gait speed were not affected on a group level. The prevalence of frailty (pre-frail 20% or frail 10%) was high among the survivors. In multiple regression analysis, chronic graft-versus-host disease, shorter stature, higher body fat mass and hazardous drinking predicted prefrail/frail status. Common cardiovascular risk factors, such as increased levels of serum triglycerides, higher resting heart rate and diastolic blood pressure, were associated with lower physical fitness. Conclusion: Low muscle strength and a high incidence of frailty were observed in survivors of pediatric HSCT. There is a predominant risk of cardiovascular and metabolic diseases in the long-term.
DNA Barcoding and Species Delimitation for Dogfish Sharks Belonging to the Squalus Genus (Squaliformes: Squalidae)
Authors: Ariza Ailton A. , Adachi Aisni M. C. L. , Roque Pollyana , Hazin Fabio H. V. , Vianna Marcelo , Rotundo Matheus M. , Delpiani Sergio M. , de Astarloa Juan M. Díaz , Delpiani Gabriela , Oliveira Claudio , Foresti Fausto , Cruz Vanessa P.
Published: July 2022

The Squalus genus comprises a group of small demersal sharks occurring circumglobally, popularly known as dogfish sharks. This genus exhibits a conserved morphology, thus making correct morphological identification difficult. Considering these taxonomic problems and the scarcity of molecular data, the present study aimed to identify Squalus genus MOTUs, using DNA barcoding for species delimitation via ABGD (automatic barcode gap discovery), PTP (Poisson tree process), and GMYC (general mixed Yule coalescent) employing the mitochondrial COI gene. A total of 69 sequences were generated from samples obtained from the American coast in both the Atlantic and Pacific Oceans. The ABGD analysis was the most conservative among the three applied delimitations, indicating three taxonomic units, while the PTP analysis revealed nine MOTUs, with two conflicting units noted between S. clarkae + S. mitsukurii and S. albicaudus + S. cubensis. The GMYC analysis indicated an excessive division, with S. acanthias and S. mitsukurii subdivided into six MOTUs each and S. blainville, into four. These findings demonstrated that Squalus presents a complex of previously defined species, with misidentified samples deposited in databases leading to difficulties in analyzing the real distribution and diversity of species belonging to this genus. Thus, further efforts to highlight possible new species are recommended.
Estimating Quantum Mutual Information of Continuous-Variable Quantum States by Measuring Purity and Covariance Matrix
Authors: Park Jiyong
Published: July 2022

We derive accessible upper and lower bounds for continuous-variable (CV) quantum states on quantum mutual information. The derivations are based on the observation that some functions of purities bound the difference between quantum mutual information of a quantum state and its Gaussian reference. The bounds are efficiently obtainable by measuring purities and the covariance matrix without multimode quantum state reconstruction. We extend our approach to the upper and lower bounds for the quantum total correlation of CV multimode quantum states. Furthermore, we investigate the relations of the bounds for the quantum mutual information with the bounds for the quantum conditional entropy.
Double-Color-Image Compression-Encryption Algorithm Based on Quaternion Multiple Parameter DFrAT and Feature Fusion with Preferable Restoration Quality
Authors: Xiao Meihua , Tan Ruixiao , Ye Huosheng , Gong Lihua , Zhu Zhiliang
Published: July 2022

To achieve multiple color images encryption, a secure double-color-image encryption algorithm is designed based on the quaternion multiple parameter discrete fractional angular transform (QMPDFrAT), a nonlinear operation and a plaintext-related joint permutation-diffusion mechanism. QMPDFrAT is first defined and then applied to encrypt multiple color images. In the designed algorithm, the low-frequency and high-frequency sub-bands of the three color components of each plaintext image are obtained by two-dimensional discrete wavelet transform. Then, the high-frequency sub-bands are further made sparse and the main features of these sub-bands are extracted by a Zigzag scan. Subsequently, all the low-frequency sub-bands and high-frequency fusion images are represented as three quaternion signals, which are modulated by the proposed QMPDFrAT with three quaternion random phase masks, respectively. The spherical transform, as a nonlinear operation, is followed to nonlinearly make the three transform results interact. For better security, a joint permutation-diffusion mechanism based on plaintext-related random pixel insertion is performed on the three intermediate outputs to yield the final encryption image. Compared with many similar color image compression-encryption schemes, the proposed algorithm can encrypt double-color-image with higher quality of image reconstruction. Numerical simulation results demonstrate that the proposed double-color-image encryption algorithm is feasibility and achieves high security.
Uniform Finite Element Error Estimates with Power-Type Asymptotic Constants for Unsteady Navier–Stokes Equations
Authors: Xie Cong , Wang Kun
Published: July 2022

Uniform error estimates with power-type asymptotic constants of the finite element method for the unsteady Navier–Stokes equations are deduced in this paper. By introducing an iterative scheme and studying its convergence, we firstly derive that the solution of the Navier–Stokes equations is bounded by power-type constants, where we avoid applying the Gronwall lemma, which generates exponential-type factors. Then, the technique is extended to the error estimate of the long-time finite element approximation. The analyses show that, under some assumptions on the given data, the asymptotic constants in the finite element error estimates for the unsteady Navier–Stokes equations are uniformly power functions with respect to the initial data, the viscosity, and the body force for all time t>0. Finally, some numerical examples are shown to verify the theoretical predictions.
Artificial Intelligence-Based Multimodal Medical Image Fusion Using Hybrid S2 Optimal CNN
Authors: Almasri Marwah Mohammad , Alajlan Abrar Mohammed
Published: July 2022

In medical applications, medical image fusion methods are capable of fusing the medical images from various morphologies to obtain a reliable medical diagnosis. A single modality image cannot provide sufficient information for an exact diagnosis. Hence, an efficient multimodal medical image fusion-based artificial intelligence model is proposed in this paper. Initially, the multimodal medical images are obtained for an effective fusion process by using a modified discrete wavelet transform (MDWT) thereby attaining an image with high visual clarity. Then, the fused images are classified as malignant or benign using the proposed convolutional neural network-based hybrid optimization dynamic algorithm (CNN-HOD). To enhance the weight function and classification accuracy of the CNN, a hybrid optimization dynamic algorithm (HOD) is proposed. The HOD is the integration of the sailfish optimizer algorithm and seagull optimization algorithm. Here, the seagull optimizer algorithm replaces the migration operation toobtain the optimal location. The experimental analysis is carried out and acquired with standard deviation (58%), average gradient (88%), and fusion factor (73%) compared with the other approaches. The experimental results demonstrate that the proposed approach performs better than other approaches and offers high-quality fused images for an accurate diagnosis.
Research on Analog-to-Digital Converter (ADC) Dynamic Parameter Method Based on the Sinusoidal Test Signal
Authors: Jiang Jie , Li Jie , Zhang Debiao , Hu Chenjun , Peng Xiaofei , Sun Ning , Wang Shuai , Zhang Zeyu , Cui Wentao
Published: July 2022

The acquisition of dynamic analog-to-digital converter (ADC) parameters is becoming increasingly relevant as electronic information develops at a rapid pace. The fundamental challenge of the spectrum test for ADC is that coherent sampling is difficult to achieve, especially because of the high accuracy of the excitation signal necessary for coherent sampling. Therefore, incoherent sampling is certainly unavoidable in the actual test. If the coherent sampling condition is not reached in the test, spectrum leaks from test data after Discrete Fourier Transform (DFT) analysis, resulting in inaccurate parameters. In this study, a new breakdown and reconstruction method was presented using the Ensemble Empirical Mode Decomposition (EEMD); Hilbert transform and parameter fitting method can accurately estimate the incoherent fundamental and harmonic waves, then reconstruct them to obtain accurate ADC dynamic parameters.
Using Spatial Data Science in Energy-Related Modeling of Terraforming the Martian Atmosphere
Authors: Pałka Piotr , Olszewski Robert , Wendland Agnieszka
Published: July 2022

This paper proposes a methodology for numerical modeling of terraforming Mars’ atmosphere using high-energy asteroid impact and greenhouse gas production processes. The developed simulation model uses a spatial data science approach to analyze the Global Climate Model of Mars and cellular automata to model the changes in Mars’ atmospheric parameters. The developed model allows estimating the energy required to raise the planet’s temperature by sixty degrees using different variations of the terraforming process. Using a data science approach for spatial big data analysis has enabled successful numerical simulations of global and local atmospheric changes on Mars and an analysis of the energy potential required for this process.
Inductive Power Transfer for Electric Vehicle Charging Applications: A Comprehensive Review
Authors: Aydin Emrullah , Aydemir Mehmet Timur , Aksoz Ahmet , El Baghdadi Mohamed , Hegazy Omar
Published: July 2022

Nowadays, Wireless Power Transfer (WPT) technology is receiving more attention in the automotive sector, introducing a safe, flexible and promising alternative to the standard battery chargers. Considering these advantages, charging electric vehicle (EV) batteries using the WPT method can be an important alternative to plug-in charging systems. This paper focuses on the Inductive Power Transfer (IPT) method, which is based on the magnetic coupling of coils exchanging power from a stationary primary unit to a secondary system onboard the EV. A comprehensive review has been performed on the history of the evolution, working principles and phenomena, design considerations, control methods and health issues of IPT systems, especially those based on EV charging. In particular, the coil design, operating frequency selection, efficiency values and the preferred compensation topologies in the literature have been discussed. The published guidelines and reports that have studied the effects of WPT systems on human health are also given. In addition, suggested methods in the literature for protection from exposure are discussed. The control section gives the common charging control techniques and focuses on the constant current-constant voltage (CC-CV) approach, which is usually used for EV battery chargers.
Optimization of Magnetic Gear Patterns Based on Taguchi Method Combined with Genetic Algorithm
Authors: Mao Yuan , Yang Yun
Published: July 2022

Magnetic gears (MGs) have gained increasing attention due to their sound performance in high torque density and low friction loss. Aiming to maximize the torque density, topology design has been a popular issue in recent years. However, studies on the optimization comparisons of a general MG topology pattern are very limited. This paper proposes a Taguchi-method-based optimization method for a general MG topology pattern, which can cover most of the common types of radially magnetized concentric-surface-mounted MGs (RMCSM-MGs). The Taguchi method is introduced to evaluate the influence of each parameter in MGs. Moreover, the parameter value range is re-examined based on the sensitivity analysis results. The genetic algorithm (GA) method is adopted to optimize the topology pattern in the study.
Mobile Networks’ Support for Large-Scale UAV Services
Authors: Tomaszewski Lechosław , Kołakowski Robert , Dybiec Piotr , Kukliński Sławomir
Published: July 2022

The services based on Unmanned Aerial Vehicles (UAVs) have started to be used in many countries but not on a large scale yet. The paper describes the present status of UAV services and a concept of a solution for large-scale deployment of safe and reliable UAV services that use the 5G network for communication with UAVs. Based on the Standards Developing Organizations and related industry fora activities, unmanned traffic and airspace regulations, especially the commonly supported concept of Unmanned Aircraft Systems Traffic Management (UTM), UAV-related communication requirements and 5G System (5GS) features, we have developed an alternative approach to the integration of UAV and 5GS. The proposed concept includes a set of enablers that can be provided by Mobile Network Operators in order to not only support but also leverage UAV services. As work on many items is still in progress, we identify a list of open issues and challenges and present them at the end of the paper with the main focus on the MNO–UTM provider relationship and safe flights.
Climatic Suitability and Distribution Overlap of Sawflies (Hymenoptera: Diprionidae) and Threatened Populations of Pinaceae
Authors: Sánchez-Martínez Guillermo , González-Gaona Ernesto , López-Martínez Víctor , Espinosa-Zaragoza Saul , López-Baez Orlando , Sanzón-Gómez Diana , Pérez-De la O Nidia Bélgica
Published: July 2022

Ecological Niche Models (ENM) are tools used to predict suitability, based on climatic variables selected and occurrence data of the target species, and characterize the environmental space. Sawflies (Hymenoptera: Diprionidae) are one of the main factors threatening forest health in Mexico, with cyclical population outbreaks and a wide range of hosts. In the present paper, we calculate the climatic niche in Mexico of three diprionids, Neodiprion abietis (Harris), N. omosus Smith, and Zadiprion rohweri (Middleton); the first and the latter with recent records in Mexico, and N. omosus with presence in Mexico and Guatemala; contrasting them against the distribution records of host species in the country. The climatic suitability of N. abietis was high in the Sierra Madre Occidental where its hosts, Pinus ponderosa, P. strobiformis, and P. menziesii are distributed. For N. omosus, the environmental suitability was projected towards the Southern Altiplano, where it coincides with a small presence of its hosts P. leiophylla and P. ayacahuite; however, it was possible to calculate its coincidence with more hosts in other biogeographic provinces. Pinaceae species considered under threat, Abies concolor, P. monophylla, and P. strobiformis, have populations within the environmental suitability of the sawflies.
Biofuels Production and Processing Technology
Authors: Tropea Alessia
Published: July 2022

The negative global warming impact and global environmental pollution due to fossil fuels mean that the main challenge of modern society is finding alternatives to conventional fuels. In this scenario, biofuels derived from renewable biomass represent the most promising renewable energy sources. Depending on the biomass used by the fermentation technologies, it is possible obtain first-generation biofuels produced from food crops, second-generation biofuels produced from non-food feedstock, mainly starting from renewable lignocellulosic biomasses, and third-generation biofuels, represented by algae or food waste biomass. Although biofuels appear to be the closest alternative to fossil fuels, it is necessary for them to be produced in competitive quantities and costs, requiring both improvements to production technologies and diversification of feedstock. This Special Issue is focused on technological innovations, which include but are not limited to the utilization of different feedstock; different biomass pretreatments; fermentation strategies, such as simultaneous saccharification and fermentation (SSF) or separate hydrolysis and fermentation (SHF); different applied microorganisms used as monoculture or co-culture; and different setups for biofuel fermentation processes.
Exploring the Mutational Landscape of Isolated Congenital Heart Defects: An Exome Sequencing Study Using Cardiac DNA
Authors: Meerschaut Ilse , Steyaert Wouter , Bové Thierry , François Katrien , Martens Thomas , De Groote Katya , De Wilde Hans , Muiño Mosquera Laura , Panzer Joseph , Vandekerckhove Kristof , Moons Lara , Vermassen Petra , Symoens Sofie , Coucke Paul J. , De Wolf Daniël , Callewaert Bert
Published: July 2022

Congenital heart defects (CHD) are the most common congenital anomalies in liveborn children. In contrast to syndromic CHD (SCHD), the genetic basis of isolated CHD (ICHD) is complex, and the underlying pathogenic mechanisms appear intricate and are incompletely understood. Next to rare Mendelian conditions, somatic mosaicism or a complex multifactorial genetic architecture are assumed for most ICHD. We performed exome sequencing (ES) in 73 parent–offspring ICHD trios using proband DNA extracted from cardiac tissue. We identified six germline de novo variants and 625 germline rare inherited variants with ‘damaging’ in silico predictions in cardiac-relevant genes expressed in the developing human heart. There were no CHD-relevant somatic variants. Transmission disequilibrium testing (TDT) and association testing (AT) yielded no statistically significant results, except for the AT of missense variants in cilia genes. Somatic mutations are not a common cause of ICHD. Rare de novo and inherited protein-damaging variants may contribute to ICHD, possibly as part of an oligogenic or polygenic disease model. TDT and AT failed to provide informative results, likely due to the lack of power, but provided a framework for future studies in larger cohorts. Overall, the diagnostic value of ES on cardiac tissue is limited in individual ICHD cases.
A Modeling Approach for Quantifying Human-Beneficial Terpene Emission in the Forest: A Pilot Study Applying to a Recreational Forest in South Korea
Authors: Choi Kwanghun , Ko Dongwook W. , Kim Ki Weon , Shin Man Yong
Published: July 2022

(1) Background: Recent economic developments in South Korea have shifted people’s interest in forests from provisioning to cultural services such as forest healing. Although policymakers have attempted to designate more forests for healing purposes, there are few established standards for carrying out such designations based on the quantified estimation. (2) Methods: We suggest a modeling approach to estimate and analyze the emission rate of human-beneficial terpenes. For this purpose, we adopted and modified the Model of Emissions of Gases and Aerosols from Nature (MEGAN), a commonly used biogenic volatile organic compounds (BVOCs) estimation model which was suitable for estimating the study site’s terpene emissions. We estimated the terpene emission rate for the whole year and analyzed the diurnal and seasonal patterns. (3) Results: The results from our model correspond well with other studies upon comparing temporal patterns and ranges of values. According to our study, the emission rate of terpenes varies significantly temporally and spatially. The model effectively predicted spatiotemporal patterns of terpene emission in the study site. (4) Conclusions: The modeling approach in our study is suitable for quantifying human-beneficial terpene emission and helping policymakers and forest managers plan the efficient therapeutic use of forests.
The Cardiovascular Disease (CVD) Risk Continuum from Prenatal Life to Adulthood: A Literature Review
Authors: Faienza Maria Felicia , Urbano Flavia , Lassandro Giuseppe , Valente Federica , D’Amato Gabriele , Portincasa Piero , Giordano Paola
Published: July 2022

The risk of developing cardiovascular diseases (CVDs) arises from the interaction of prenatal factors; epigenetic regulation; neonatal factors; and factors that affect childhood and adolescence, such as early adiposity rebound (AR) and social and environmental influences. Thus, CVD risk varies between the group of low-risk metabolically healthy normal-weight subjects (MHNW); the intermediate-risk group, which includes metabolically healthy obese (MHO) and metabolically unhealthy normal-weight subjects (MUHNW); and the high-risk group of metabolically unhealthy obese (MUHO) subjects. In this continuum, several risk factors come into play and contribute to endothelial damage, vascular and myocardial remodeling, and atherosclerotic processes. These pathologies can occur both in prenatal life and in early childhood and contribute to significantly increasing CVD risk in young adults over time. Early intervention in the pediatric MUHO population to reduce the CVD risk during adulthood remains a challenge. In this review, we focus on CVD risk factors arising at different stages of life by performing a search of the recent literature. It is urgent to focus on preventive or early therapeutic strategies to stop this disturbing negative metabolic trend, which manifests as a continuum from prenatal life to adulthood.
Difference between Minorities and Majorities in the Association between COVID-19-Related Stress and Psychological Distress: A Socio-Ecological Perspective and the Moderating Role of Parenthood
Authors: Tannous-Haddad Lubna , Hadar-Shoval Dorit , Alon-Tirosh Michal , Asraf Kfir , Tzischinsky Orna
Published: July 2022

This study introduces a socio-ecological perspective of differences in psychological distress between the Palestinian minority and Jewish majority citizens of Israel during lockdown due to COVID-19. The study examines the association between COVID-19-related stress and psychological distress, and the moderating effect of parenthood. Online questionnaires, completed by 1934 participants (1391 Jews, 552 Palestinians; 1306 parents, 637 without children; 54.86% female, 45.13% male; M age = 40.38, SD = 13.77) assessed COVID-19-related stressors and depression, anxiety, and stress. The Palestinian minority showed a higher level of COVID-19-related stress and psychological distress than the Jewish majority. Parenthood showed a moderating effect on the association between COVID-19-related stress and distress for the Jewish majority but not the Palestinian minority. The results emphasize the significance of considering social status when seeking to understand the differences between minorities and majorities in terms of distress and resilience during pandemic events, and the need for cultural sensitivity and awareness when issuing instructions in such circumstances. Additionally, the results highlight the potential role of parenthood as a resilience factor, depending upon social status.
Early Pandemic Improvements in Diet Quality Are Associated with Increased Physical Activity and Weight Loss in US Adults
Authors: Gautreaux Corinne E. , Smith Kristen S. , Dolan Luke , Marlin Michael B. , Greene Michael W. , Novak Josh R. , Frugé Andrew D.
Published: July 2022

In March 2020, the COVID-19 pandemic led to restricted vocational (Voc-PA) and recreational physical activity (Rec-PA) outside of the home. We conducted a nation-wide survey in the United States (US) during the mitigation peak of the pandemic (June 2020) to assess health-related changes from the previous year. A diet quality (DQ) assessment tool weighted the relative healthfulness of eating occasions from foods prepared-at-home (Home) and away-from-home (Away). Previously-validated instruments assessed PA and demographic variables; height/weight were self-reported to calculate body mass index (BMI). T-tests explored longitudinal, between-sex, and obesity status differences in DQ, PA, and BMI; Pearson correlations explored associations. Of 1648 respondents, 814 valid responses (56.8% female, 81.7% white) were analyzed. Overall and Home DQ was higher for females than males in 2020 (p < 0.001 for both). Respondents increased DQ from 2019 to 2020, primarily from Away (p < 0.001 for both sexes). Total Rec-PA and Voc-PA was higher in males (p = 0.002, p < 0.001) than females in 2020; females reported higher other PA (p = 0.001). Change in BMI was inversely associated with change in both DQ and PA (p < 0.001 for both). In this sample of US adults, early adaptations to the COVID-19 pandemic included improved DQ and BMI. Whether these short-term improvements were maintained warrant further investigation.
Investigating Inclusive Leadership and Pro-Social Rule Breaking in Hospitality Industry: Important Role of Psychological Safety and Leadership Identification
Authors: Khattak Sajid Rahman , Zada Muhammad , Nouman Muhammad , Rahman Shams Ur , Fayaz Muhammad , Ullah Rezwan , Salazar-Sepúlveda Guido , Vega-Muñoz Alejandro , Contreras-Barraza Nicolás
Published: July 2022

This study aims to empirically examine the mediating effects of psychological safety and leadership identification on the relationship between inclusive leadership and pro-social rule breaking among hospitality employees. This study analyzes the survey data collected in three waves from 589 employees working in different hotels and restaurants operating in the Northern areas of Khyber Pakhtunkhwa, Pakistan. The scale validity, composite reliability, and hypotheses were assessed through PLS-SEM. The study found that inclusive leadership significantly impacts employees’ pro-social rule-breaking. The study also found that leadership identification and psychological safety partially mediate the relationship between inclusive leadership and pro-social rule-breaking. Hospitality leaders can practice inclusive leadership characteristics because it may significantly enhance employee engagement in pro-social rule-breaking. Through their inclusive features, hospitality leaders can improve employees’ psychological safety and leadership identification, enhancing frontline employees’ pro-social rule-breaking.
Comparing Environmental Policies to Reduce Pharmaceutical Pollution and Address Disparities
Authors: Desai Meghana , Njoku Anuli , Nimo-Sefah Lillian
Published: July 2022

Pharmaceutical products, including active pharmaceutical ingredients and inactive ingredients such as packaging materials, have raised significant concerns due to their persistent input and potential threats to human and environmental health. Discourse on reducing pharmaceutical waste and subsequent pollution is often limited, as information about the toxicity of pharmaceuticals in humans is yet to be fully established. Nevertheless, there is growing awareness about ecotoxicity, and efforts to curb pharmaceutical pollution in the European Union (EU), United States (US), and Canada have emerged along with waste disposal and treatment procedures, as well as growing concerns about impacts on human and animal health, such as through antimicrobial resistance. Yet, the outcomes of such endeavors are often disparate and involve multiple agencies, organizations, and departments with little evidence of cooperation, collaboration, or oversight. Environmental health disparities occur when communities exposed to a combination of poor environmental quality and social inequities experience more sickness and disease than wealthier, less polluted communities. In this paper, we discuss pharmaceutical environmental pollution in the context of health disparities and examine policies across the US, EU, and Canada in minimizing environmental pollution.
Research on the Limit Values of Reclamation Based on Ecological Security: A Case Study of Tongzhou Bay in Rudong, Jiangsu Province
Authors: Zhang Haifeng , Zhao Lin , Du Wen , Liu Qing , Zhao Yifei , Xu Min
Published: July 2022

Due to the growing demand for land resources, many coastal reclamation projects have been implemented around the world in recent decades. Although coastal zone reclamation provides economic benefits, it produces a series of threats to coastal environments and ecosystems. Hence, the ecological costs and economic benefits of reclamation projects must be balanced. In this study, we select Tongzhou Bay, a key development area of the marine industry in the Jiangsu Province, as the research region to study the limits of reclamation control of the port operation area based on regional ecological security. First, we determine the standard limit values of the tidal catchment water line and the water dividing line, the change rate of the tidal flux ±5%, and water area of sandbars above the 0 m line based on key factors and evaluation indices for the ecological impact of reclamation in this region. Then, eight reclamation cases are investigated in Tongzhou Bay, which include the undeveloped natural state, development status, construction projects to be built, and possible construction scale based on the results of tidal current numerical simulation calculations. Although case 3 has impacts on Section 2 (DM2) tidal flux of less than 5% and on Section 1 (DM1) tidal flux of less than 10%, it causes a northward shift of the flood catchment water line in the middle of Yaosha. Finally, case 8 meets the requirements of the standard limit values of evaluation indicators, e.g., 1455 hectares of reclamation is the limit value to maintain the natural state of the Sanshahong channel and the stability of the tidal creek system and Yaosha. Therefore, the results suggest optimizing the structure and layout of breakwaters, controlling the restriction of reclamation, and further maintaining and protecting the ecological function of Tongzhou Bay.
Barriers to COVID-19 Intervention Implementation in K-5 Classrooms: A Survey of Teachers from a District with Mask Mandates despite a Statewide Mask Mandate Ban
Authors: Wilson Amanda M. , Ogunseye Olusola O. , DiGioia Olivia , Gerald Lynn B. , Lowe Ashley A.
Published: July 2022

The study objective was to characterize K-5 teachers’ risk perceptions and experiences with CDC COVID-19 classroom guidance in an Arizona school district with a mask mandate, conflicting with a statewide mask mandate ban. Methods: Public school teachers (n = 111) were recruited between 14 December 2021, and 31 January 2022, for an anonymous online survey with questions on seven important topics related to: (1) population demographics, (2) teachers’ perceptions of COVID-19 in the workplace, (3) masks, (4) physical distancing, (5) surface transmission routes, (6) air flow, and (7) contact tracing protocols. Descriptive statistics were calculated, and statistically significant differences in categorical responses by grade level taught were investigated with Fisher’s exact test. Results: There were 76 complete responses. No significant differences across grade levels were found. More than half (53%, 43/81) reported not feeling protected from occupational COVID-19 exposure. Lack of mask usage/enforcement was the most frequently listed reason (40%, 17/42). Physical distancing barriers included large student-teacher ratios. Conclusions: Consistent mask guidance at state and local levels, increased financial support, and lower student-teacher ratios may improve the implementation of CDC guidance for classrooms. Conflicting statewide and district-level school mask policies may negatively impact teachers’ risk perceptions.
Chromatin Molecular Complexes—Functional Organization, Protection and Regulation of the Genome
Authors: Hofr Ctirad
Published: July 2022

This Special Issue highlights the advantages of using combined approaches to explore chromatin molecular complexes [...]
Bioavailability Improvement Strategies for Icariin and Its Derivates: A Review
Authors: Szabó Róbert , Rácz Csaba Pál , Dulf Francisc Vasile
Published: July 2022

In recent years, there has been considerable interest in icariin (ICA) and its derivates, icariside II (ICS) and icaritin (ICT), due to their wide range of potential applications in preventing cancer, cardiovascular disease, osteoporosis, delaying the effects of Alzheimer’s disease, treating erectile dysfunction, etc. However, their poor water solubility and membrane permeability, resulting in low bioavailability, dampens their potential beneficial effects. In this regard, several strategies have been developed, such as pharmaceutical technologies, structural transformations, and absorption enhancers. All these strategies manage to improve the bioavailability of the above-mentioned flavonoids, thus increasing their concentration in the desired places. This paper focuses on gathering the latest knowledge on strategies to improve bioavailability for enhancing the efficacy of icariin, icariside II, and icaritin. We conclude that there is an opportunity for many further improvements in this field. To the best of our knowledge, no such review articles scoping the bioavailability improvement of icariin and its derivates have been published to date. Therefore, this paper can be a good starting point for all those who want to deepen their understanding of the field.
Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells
Authors: Kim Jin Hyung , Lee Seung-Taek
Published: July 2022

Polyamine levels decrease with menopause; however, little is known about the mechanisms regulated by menopause. In this study, we found that among the genes involved in the polyamine pathway, polyamine oxidase (PAOX) mRNA levels were the most significantly reduced by treatment with 17β-estradiol in estrogen receptor (ESR)-positive MCF-7 breast cancer cells. Treatment with 17β-estradiol also reduced the PAOX protein levels. Treatment with selective ESR antagonists and knockdown of ESR members revealed that estrogen receptor 2 (ESR2; also known as ERβ) was responsible for the repression of PAOX by 17β-estradiol. A luciferase reporter assay showed that 17β-estradiol downregulates PAOX promoter activity and that 17β-estradiol-dependent PAOX repression disappeared after deletions (−3126/−2730 and −1271/−1099 regions) or mutations of activator protein 1 (AP-1) binding sites in the PAOX promoter. Chromatin immunoprecipitation analysis showed that ESR2 interacts with AP-1 bound to each of the two AP-1 binding sites. These results demonstrate that 17β-estradiol represses PAOX transcription by the interaction of ESR2 with AP-1 bound to the PAOX promoter. This suggests that estrogen deficiency may upregulate PAOX expression and decrease polyamine levels.
Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence
Authors: Yang Shuaiqi , Zhang Xiangmin , Li Xianpeng , Yin Xiu , Teng Lei , Ji Guangdong , Li Hongyan
Published: July 2022

MOV10 and MOV10L1 both encode ATP-dependent RNA helicases. In mammals, MOV10 and MOV10L1 participate in various kinds of biological contexts, such as defense of RNA virus invasion, neuron system, germ cell and early development. However, mov10 and mov10l1 in zebrafish are obscure and the evolutionary relationships of mov10 among different species remain unclear. In this study, we found MOV10 and MOV10L1 had some variations despite they possessed the conserved feature of RNA helicase, however, they may originate from a single ancestor although they shared limited homology. A single MOV10L1 gene existed among all species, while MOV10 gene experienced lineage-specific intra-chromosomal gene duplication in several species. Interestingly, the mov10 gene expanded to three in zebrafish, which originating from a duplication by whole genome specific duplication of teleost lineage followed by a specific intra-chromosome tandem duplication. The mov10 and mov10l1 showed distinct expression profiles in early stages, however, in adult zebrafish, three mov10 genes exhibited similar diverse expression patterns in almost all tissues. We also demonstrated mov10 genes were upregulated upon virus challenge, highlighting they had redundant conserved roles in virus infection. These results provide valuable data for the evolution of MOV10 and MOV10L1 and they are important to the further functional exploration.
Current Advances and Future Prospects for Molecular Research for Agronomically Important Traits in Rice
Authors: Hori Kiyosumi , Shenton Matthew
Published: July 2022

Rice (Oryza sativa L [...]
4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline
Authors: Fai Leong Ka , Anyanwu Margrate , Ai Jiang , Xie Yuhan , Gianoncelli Alessandra , Ribaudo Giovanni , Coghi Paolo
Published: July 2022

The 1,2,3-triazole ring system can be easily obtained by widely used copper-catalyzed click reaction of azides with alkynes. 1,2,3-triazole exhibits myriad of biological activities, including antibacterial antimalarial, and antiviral activities. We herein reported the synthesis of quinoline-based [1,2,3]-triazole hybrid derivative via Cu(I)-catalyzed click reaction of 4-azido-7-chloroquinoline with alkyne derivative of hydroxybenzotriazole (HOBt). The compound was fully characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), correlated spectroscopy (1H-1H-COSY), heteronuclear single quantum coherence (HSQC) and distortionless enhancement by polarization transfer (DEPT-135 and DEPT-90) NMR, ultraviolet (UV) and Fourier-transform infrared (FTIR) spectroscopies, and high-resolution mass spectrometry (HRMS). Computational studies were enrolled to predict the interaction of the synthesized compound with acetylcholinesterase, a target of primary relevance for developing new therapeutic options to counteract neurodegeneration. Moreover, the drug-likeness of the compound was also investigated by predicting its pharmacokinetic properties.
Effects of Initial Morphology on Growth Kinetics of Cu6Sn5 at SAC305/Cu Interface during Isothermal Aging
Authors: Lee Jia-Yi , Chen Chih-Ming
Published: July 2022

Solder/Cu joints are important components responsible for interconnection in microelectronics. Construction of the solder/Cu joints through liquid/solid (L/S) reactions accompanies the formation of the Cu–Sn intermetallic compounds (IMCs) at the joint interface. The Cu6Sn5 IMC exhibits remarkable distinctions in thickness and morphology upon increasing the L/S reaction time. Effects of the initial characteristics of thickness and morphology on the growth kinetics of Cu6Sn5 during subsequent isothermal aging were investigated. SAC305 solder was reflowed on a Cu electroplated layer at 265 °C for 1 to 60 min to produce the Cu6Sn5 IMC with different thickness and morphology at the SAC305/Cu interface. The as-fabricated SAC305/Cu joint samples were aged at 200 °C for 72 to 360 h to investigate the growth kinetics of Cu6Sn5. The results show that the initial characteristics of thickness and morphology significantly influenced the growth kinetics of Cu6Sn5 during the subsequent solid/solid (S/S) reaction. A prolonged L/S reaction time of 60 min (L/S-60) produced a scallop-type Cu6Sn5 IMC with a larger grain size and a thicker thickness, which reduced the quantity of fast diffusion path (grain boundary) and the magnitude of concentration gradient, thus slowing down the growth rate of Cu6Sn5. According to the growth kinetics analysis, the growth rate constant of Cu6Sn5 could be remarkably reduced to 0.151 µm/h0.5 for the L/S-60 sample, representing a significant reduction of 70 % compared to that of the L/S-1 sample (0.508 µm/h0.5 for L/S reaction time of 1 min).
Influence of Addition of Antibiotics on Chemical and Surface Properties of Sol-Gel Coatings
Authors: Toirac Beatriz , Garcia-Casas Amaya , Monclús Miguel A. , Aguilera-Correa John J. , Esteban Jaime , Jiménez-Morales Antonia
Published: July 2022

Infection is one of the most common causes that leads to joint prosthesis failure. In the present work, biodegradable sol-gel coatings were investigated as a promising controlled release of antibiotics for the local prevention of infection in joint prostheses. Accordingly, a sol-gel formulation was designed to be tested as a carrier for 8 different individually loaded antimicrobials. Sols were prepared from a mixture of MAPTMS and TMOS silanes, tris(tri-methylsilyl)phosphite, and the corresponding antimicrobial. In order to study the cross-linking and surface of the coatings, a battery of examinations (Fourier-transform infrared spectroscopy, solid-state 29Si-NMR spectroscopy, thermogravimetric analysis, SEM, EDS, AFM, and water contact angle, thickness, and roughness measurements) were conducted on the formulations loaded with Cefoxitin and Linezolid. A formulation loaded with both antibiotics was also explored. Results showed that the coatings had a microscale roughness attributed to the accumulation of antibiotics and organophosphites in the surface protrusions and that the existence of chemical bonds between antibiotics and the siloxane network was not evidenced.