bluuebunny/crossref_metadata_2025 huggingface dataset:
Alterations of Neuronal Lysosomes in Alzheimer’s Disease and in APPxPS1-KI Mice
Authors: Androuin Alexandre ,   Brainbank NeuroCEB Neuropathology Network, Thierry Manon , Boluda Susana , Baskaran Asha , Langui Dominique , Duyckaerts Charles , Potier Marie-Claude , El Hachimi Khalid Hamid , Delatour Benoît , Marty Serge
Published: March 2022

Background: The cellular and molecular alterations associated with synapse and neuron loss in Alzheimer’s disease (AD) remain unclear. In transgenic mouse models that express mutations responsible for familial AD, neuronal and synaptic losses occur in populations that accumulate fibrillar amyloid-β 42 (Aβ42) intracellularly. Objective: We aimed to study the subcellular localization of these fibrillar accumulations and whether such intraneuronal assemblies could be observed in the human pathology. Methods: We used immunolabeling and various electron microscopy techniques on APP x presenilin1 - knock-in mice and on human cortical biopsies and postmortem samples. Results: We found an accumulation of Aβ fibrils in lipofuscin granule-like organelles in APP x presenilin1 - knock-in mice. Electron microscopy of human cortical biopsies also showed an accumulation of undigested material in enlarged lipofuscin granules in neurons from AD compared to age-matched non-AD patients. However, in those biopsies or in postmortem samples we could not detect intraneuronal accumulations of Aβ fibrils, neither in the lipofuscin granules nor in other intraneuronal compartments. Conclusion: The intralysosomal accumulation of Aβ fibrils in specific neuronal populations in APPxPS1-KI mice likely results from a high concentration of Aβ42 in the endosome-lysosome system due to the high expression of the transgene in these neurons.
A Multi-Dimensional Comparison of Alzheimer’s Disease Neurodegenerative Biomarkers
Authors: Liu Ying ,   Alzheimer’s Disease Neuroimaging Initiative, Han Pei-Ran , Hu Hao , Wang Zuo-Teng , Guo Yu , Ou Ya-Nan , Cao Xi-Peng , Tan Lan , Yu Jin-Tai
Published: March 2022

Background: In the 2018 AT(N) framework, neurodegenerative (N) biomarkers plays an essential role in the research and staging of Alzheimer’s disease (AD); however, the different choice of N may result in discordances. Objective: We aimed to compare different potential N biomarkers. Methods: We examined these N biomarkers among 1,238 participants from Alzheimer’s Disease Neuroimaging Initiative (ADNI) in their 1) diagnostic utility, 2) cross-sectional and longitudinal correlations between different N biomarkers and clinical variables, and 3) the conversion risk of different N profiles. Results: Six neurodegenerative biomarkers changed significantly from preclinical AD, through prodromal AD to AD dementia stage, thus they were chosen as the candidate N biomarkers: hippocampal volume (HV), 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET), cerebrospinal fluid (CSF), total tau (T-tau), plasma neurofilament light chain (NFL), CSF NFL, and CSF neurogranin (Ng). Results indicated that FDG-PET not only had the greatest diagnostic utility in differentiating AD from controls (area under the curve: FDG-PET, 0.922), but also had the strongest association with cognitive scores. Furthermore, FDG-PET positive group showed the fastest memory decline (hazard ratio: FDG-PET, 3.45), which was also true even in the presence of amyloid-β pathology. Moreover, we observed great discordances between three valuable N biomarkers (FDG-PET, HV, and T-tau). Conclusion: These results underline the importance of using FDG-PET as N in terms of cognitive decline and AD conversion, followed by HV, and could be a great complement to the AT(N) framework.
Safety and Efficacy of Monoclonal Antibodies for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Published and Unpublished Clinical Trials
Authors: Lacorte Eleonora , Ancidoni Antonio , Zaccaria Valerio , Remoli Giulia , Tariciotti Leonardo , Bellomo Guido , Sciancalepore Francesco , Corbo Massimo , Lombardo Flavia L. , Bacigalupo Ilaria , Canevelli Marco , Piscopo Paola , Vanacore Nicola
Published: March 2022

Background: Monoclonal antibodies (mAbs) are currently among the most investigated targets for potential disease-modifying therapies in Alzheimer’s disease (AD). Objective: Our objectives were to identify all registered trials investigating mAbs in MCI due to AD or AD at any stage, retrieve available published and unpublished data from all registered trials, and analyze data on safety and efficacy outcomes. Methods: A systematic search of all registered trials on ClinicalTrials.gov and EUCT was performed. Available results were searched on both platforms and on PubMed, ISI Web of Knowledge, and The Cochrane Library. Results: Overall, 101 studies were identified on 27 mAbs. Results were available for 50 trials investigating 12 mAbs. For 18 trials, data were available from both published and unpublished sources, for 21 trials only from published sources, and for 11 trials only from unpublished sources. Meta-analyses of amyloid-related imaging abnormalities (ARIA) events showed overall risk ratios of 10.65 for ARIA-E and of 1.75 for ARIA-H. The meta-analysis of PET-SUVR showed an overall significant effect of mAbs in reducing amyloid (SMD –0.88), but when considering clinical efficacy, data on CDR-SB showed that treated patients had a statistically significant but clinically non-relevant lower worsening (MD –0.15). Conclusion: Our results suggest that the risk-benefit profile of mAbs remains unclear. Research should focus on clarifying the effect of amyloid on cognitive decline, providing data on treatment response rate, and accounting for minimal clinically important difference. Research on mAbs should also investigate the possible long-term impact of ARIA events, including potential factors predicting their onset.
Handling of college students’ network public opinion crisis based on big data analysis
Authors: Fu Liang , Du Yanfang , Lai Lianfeng , Chen Weijie
Published: March 2022

As an important public utility organization and academic research institute, Colleges feature high density people, high social attention, and relatively free atmosphere of interchange ideas, where network opinion crisis are frequent. Therefore, it is critical for colleges to concentrate more on the control and management of the network opinion crisis. In the paper, it compares events of college students’ online public opinion crisis with other references. Social online public opinion crisis solutions is use for reference. Aiming at the peculiarities of college students’ mental health, it is concluded the research coping strategies based on innovative and comprehensive use of big data technology. We establish a complete emergency protection system to effectively deal with the mental health problems of college students.
Integration of art teaching resources in vertical social network
Authors: Zhang Hui
Published: March 2022

The existing art resource integration methods do not adapt to the vertical social network environment, and the integration effect of art resources cannot meet the actual needs. In order to solve this problem and improve the recall rate and integration effect of art resources information, this paper proposes the integration method of art teaching resources in the vertical social network. Build art resource database, collect art learning resource information; Classify the collection information by related rules mining method; Extract the semantic keywords of resources using the segmentation system; And build the integration platform of art course teaching resources according to the characteristics of vertical social network art resources; Dynamic regression analysis method is used to schedule the art teaching resources in multiple information flow; Use the platform maintenance module, resource input module, platform generation module and information storage module; Use Ajax asynchronous communication technology to optimize the keyword retrieval operation for the integration of art teaching resources. The experimental results verify that the feasibility of this method is high in the practical application process, and the recall rate of information integration is increased to 95%, enhancing the effect of art resource integration, and fully meeting the research requirements.
Cortical Features in Child and Adolescent Carriers of Mutant Huntingtin (mHTT)
Authors: Reasoner Erin E. , van der Plas Ellen , Langbehn Douglas R. , Conrad Amy L. , Koscik Timothy R. , Epping Eric A. , Magnotta Vincent A. , Nopoulos Peggy C.
Published: March 2022

Background: Molecular studies provide evidence that mutant huntingtin (mHTT) affects early cortical development; however, cortical development has not been evaluated in child and adolescent carriers of mHTT. Objective: To evaluate the impact of mHTT on the developmental trajectories of cortical thickness and surface area. Methods: Children and adolescents (6–18 years) participated in the KidsHD study. mHTT carrier status was determined for research purposes only to classify participants as gene expanded (GE) and gene non-expanded (GNE). Cortical features were extracted from 3T neuroimaging using FreeSurfer. Nonlinear mixed effects models were conducted to determine if age, group, and CAG repeat were associated with cortical morphometry. Results: Age-related changes in cortical morphometry were similar across groups. Expanded CAG repeat was not significantly associated with cortical features. Conclusion: While striatal development is markedly different in GE and GNE, developmental change of the cortex appears grossly normal among child and adolescent carrier of mHTT.
RETRACTED: Investigation of RPL in 6LoWPAN based elderly care monitoring system
Authors: Shabana Parveen M. , Bhuvaneswari P.T.V.
Published: March 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
RETRACTED: Hybrid neural networks with virtual flows in in medical risk classifiers
Authors: Khatatneh Khalaf , Filist Sergey , Al-Kasasbeh Riad Taha , Aikeyeva Altyn Amanzholovna , Namazov Manafaddin , Shatalova Olga , Shaqadan Ashraf , Miroshnikov Andrey
Published: March 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
The effectiveness of vitamin D supplementation in reducing depressive symptoms: A systematic review and meta-analysis of Randomized Controlled Trials (RCTs)
Authors: Albuloshi T. , Dimala C.A. , Kuhnle G.G.C. , Bouhaimed M. , Dodd G.F. , Spencer J.P.E.
Published: March 2022

BACKGROUND:

Depression is a widespread, global problem, increasingly linked with vitamin D deficiency in the literature. However, a knowledge gap persists regarding the relationship between depressive symptoms and vitamin D intake.

OBJECTIVE:

To determine the association between vitamin D supplementation and depressive symptoms in adults (aged 18+ years).

METHODS:

This study consists of a systematic review and meta-analysis of randomized controlled trials (RCTs), published before January 2019. Pooled summary estimates and between-study heterogeneity were examined.

RESULTS:

Ten RCTs (total participants = 3336; median duration = 12 months) were included. An association was found between high vitamin D supplementation (≥4000 IU) and reduced depressive symptoms, but not in the case of lower levels of vitamin D supplementation (<4000 IU). Neither baseline serum vitamin D before supplementation, nor the depression-scoring scales used affected this association. The overall quality of evidence was graded as ‘moderate’.

CONCLUSIONS:

Vitamin D supplementation at greater than 4000 IU was observed to have a positive effect on depressive symptoms. Future efforts could focus on obtaining higher-quality evidence with standardized RCT methodologies to confirm this association.
Efficacy of lateral truncal tilt training with a wedge on postural vertical and activities of daily living in recovery phase after stroke: A randomized crossover trial
Authors: Sawa Kota , Amimoto Kazu , Ishigami Keisuke , Miyamoto Takuya , Setoyama Chika , Suzuki Rikuya , Nozomi Kuwabara , Tamura Miko , Miyagami Mitsusuke
Published: March 2022

BACKGROUND: The subjective postural vertical (SPV) is affected by training that requires participants to maintain balance; training to achieve sitting balance may also help SPV recovery and activities of daily living (ADLs). OBJECTIVE: This study aimed to assess the medium-term effects of balance training on the postural vertical (PV) and ADLs in patients with stroke. METHODS: Thirty-three patients with stroke were enrolled in this randomized crossover trial. The outcomes were SPV, SPV with eyes opened (SPV-EO), and the Functional Independent Measure (FIM) after the 14-day intervention of experimental or control training. Experimental training consisted of a maximum lateral truncal tilt to the paretic side at 0.25 Hz with or without a 10° wedge, repeated 60 times. Repeated-measures two-way analysis of variance was performed with two factors: intervention and the intervention period. RESULTS: There was no interaction between the control condition and the PV, but there was interaction between the intervention period and using a wedge for SPV variability errors. FIM showed an interaction between the intervention period and the use of a wedge. CONCLUSIONS: Balance training while sitting with a wedge significantly improved the SPV and FIM. This improved cognition and perception, which facilitate difficult dynamic tasks in ADLs.
Evaluation of sense of position and agency in children with diplegic cerebral palsy: A pilot study
Authors: Cristella Giovanna , Allighieri Martina , Pasquini Guido , Simoni Laura , Antonetti Antonella , Beni Chiara , Macchi Claudio , Ferrari Adriano
Published: March 2022

PURPOSE: This study explores non-motor impairment of the upper dominant limb in children with diplegic cerebral palsy (CP). Specifically, it firstly investigates sense of position without visual control, ability to compare visual and proprioceptive information, and capacity to recognize effects of self-movement. Secondly, it explores the possible association between these items with cognitive function, perceptual disorder (PD), and manual ability (Manual Ability Classification System -MACS). METHODS: Ten subjects (7 female; 3 male) were tested with three protocols: the first one (A) explored sense of position, the second one (B) collimation between visual and proprioceptive information, and the last one (C) sense of agency with the use of videogames. RESULTS: All subjects executed Protocol A without making any mistakes, while in Protocol B the median percentage of mistakes was 4.8%. Mistakes were recorded more frequently in positions characterized by wrist extension. Data reported a significant correlation with Processing Speed Index (PSI). Sense of agency was positively associated with cognitive functioning, with a significant correlation with PSI. PD, MACS, and Video-Gaming Experience (VGE) showed no correlation with Protocol C. CONCLUSION: In the observed sample with diplegic CP, preliminary data support the hypothesis that there is an alteration of both sense of position and sense of agency. They were both associated to PSI, with a positive trend of correlation with cognitive functioning. PD seemed to have no influence. Further studies, with a larger sample size, a control group, and involving children without CP, are required to corroborate the results obtained.
Effect of total number of pulses of radial extracorporeal shock wave therapy (rESWT) on hamstring muscle spasticity in children with spastic type cerebral palsy: A randomized clinical trial
Authors: Wardhani Rizky Kusuma , Wahyuni Luh Karunia , Laksmitasari Budiati , Lakmudin Alvin
Published: March 2022

PURPOSE: To evaluate the efficacy and safety of radial extracorporeal shock wave therapy (rESWT) according to total number of pulses on hamstring muscle spasticity in children with spastic type cerebral palsy (CP). METHODS: This study is a randomized controlled trial consisting of thirteen patients with spastic CP, 9 males and 4 females, aged 5 to 14 years (mean age 9.2). Twenty-five spastic hamstring muscles were divided in four groups. Group I: 500 pulses, Group II: 1,000 pulses, Group III: 1,500 pulses, and Group IV: 2,000 pulses. Australian Spasticity Assessment Scale (ASAS) was measured at four different time points (pre-ESWT, post-ESWT, 2 weeks post-ESWT, and 4 weeks post-ESWT). RESULTS: All four groups showed improvement in ASAS relative to pre-treatment, although only significant in Group III (1,500 pulses). There were no statistically significant differences in ASAS between all four groups in pre-ESWT [|2(2) = 3.907, p = 0.272], immediately post-ESWT [|2(2) = 1.250, p = 0.741], 2 weeks post-ESWT vs pre-ESWT [|2(2) = 3.367, p = 0.338], and 4 weeks post-ESWT vs pre-ESWT [|2(2) = 1.566, p = 0.667]. CONCLUSION: The effect of rESWT on spastic hamstring in children with spastic CP is not dependent on the number of pulses.
CCTA-derived strain analysis in detection of regional myocardial dysfunction in coronary artery disease patients with preserved left ventricular ejection fraction: A feasibility study
Authors: Zhu Mengmeng , Gao Yujie , Wang Jun , Ge Yingqian , Zhu Yinsu , Zhu Xiaomei , Xu Yi
Published: March 2022

OBJECTIVES: To evaluate the feasibility of using coronary computed tomography angiography (CCTA)-derived strain to detect regional myocardial dysfunction in coronary artery disease (CAD) patients with normal left ventricular ejection fraction (LVEF). METHODS: A total of 1,580 segments from 101 patients who underwent stressed CT myocardial perfusion imaging (CT-MPI) and CCTA were retrospectively enrolled in this study. The CT-derived global and segmental strain values were evaluated using the feature tracking technique. Segments with myocardial blood flow (MBF) < 125 ml/min/100 ml and 95 ml/min/100 ml were categorized as ischemic and infarcted, respectively. RESULTS: Segmental radial strain (SRS) and segmental circumferential strain (SCS) in the abnormal segments (including all segments with MBF < 125 ml/min/100 ml) were significantly lower than those in the normal segments (14.81±8.65% vs 17.17±9.13%, p < 0.001; –10.21±5.79% vs –11.86±4.52%, p < 0.001, respectively). SRS and SCS values in infarcted segments were significantly impaired compared with the ischemic segments (12.43±8.03% vs. 15.32±8.71%, p = 0.038; –7.72±5.91% vs. –10.67±5.66%, p = 0.010, respectively). The AUCs for SRS and SCS in detecting infarcted segments were 0.622 and 0.698, respectively (p < 0.05). CONCLUSIONS: It is feasible for using CCTA-derived strain parameters to detect regional myocardial dysfunction in CAD patients with preserved LVEF. Segmental radial and circumferential strain have the potential ability to distinguish myocardial ischemia from infarction, and normal from ischemic myocardium.
A kínvallatás tilalmának megjelenése a mai kor büntetőjogában, Beccaria szellemében
Authors: Kovács István
Published: March 2022

A Dei delitti e delle pene című könyv alapjaiban határozta meg a mai modern büntetőjog alapelveit. A könyv eredetét és szerzőségét legtöbben Beccariának tulajdonítják, de annak szerzősége körül korában és később is számos vita alakult ki. Tanulmányomban a forráskritika módszerével az „Öklök Társaságának” emlékiratait, az egyes tagok visszaemlékezését is elemzés tárgyává teszem, több magyar nyelvű fordítást is megvizsgálok, amely a szerzőség körül kialakult vitát más aspektusból is megismerteti. Mindemellett a tanulmányban a könyvben tárgyalt kínvallatás módszerét történeti és jogi szempontból is bemutatom, valamint kvantitatív eljárás segítségével megvizsgálom, hogy Magyarországon e bűncselekménnyel kapcsolatban milyen eljárások voltak folyamatban az elmúlt években, azoknak mik a tendenciái. Vajon ma Magyarországon a kínvallatás a hatóság egyik eszköze, vagy az emberi és alkotmányos jogok gyakorlása érvényesül, és a kötelemteljesítés is törvényben meghatározott feltételek szerint alakul.
A Kúria gyakorlatából
Authors: Berkes Bálint
Published: March 2022

A Kúria ítélkező és nemperes tanácsai 2021. június 1-je és november 15-e között az Alaptörvény alapvető jogokat és kötelességeket szabályozó Szabadság és felelősség című fejezetéhez kapcsolódóan több alapjog érvényesülését vizsgálták, így döntést hoztak a családi élet tiszteletben tartásához való jogot, a közérdekű adatok megismeréséhez való jogot, a gyülekezéshez való jogot, a véleménynyilvánítás és a sajtó szabadságát, a tulajdonhoz való jogot, a tisztességes hatósági és bírósági eljáráshoz való jogot, valamint a jogorvoslathoz való jogot érintő ügyekben.
Positive Psychology in the Foreign Language and Translation Classroom
Authors: Al-Jarf Reima
Published: March 2022

Results of surveys with a sample of EFL and translation instructors and students showed that many instructors feel that their role is limited to preparing the teaching material, in-class instruction, writing exams, grading assignments and other paperwork. They declared that students have many academic problems in EFL and translation and interpreting course. They added that they are unaware of positive psychology and how to apply its principles in their courses. Students’ responses and comments on social media showed that they have a negative image of themselves. They feel inadequate and are always afraid of failing their courses. If they fail, they blame it on their bad luck, on the instructor or exams. Some are not willing to try, hate school and studying. They are under stress if they have a writing or translation assignment, a class presentation, or a test. They cram and lose sleep. Based on findings of the surveys, this study proposes a model for applying the principles of positive psychology in EFL and language classrooms to help the students become happy and relaxed learners, overcome stress and anxiety, develop positive attitudes, positive affirmations, emotional resilience, positive thinking and make more achievements and improvements.  The model consists of strategies and tips for improving students’ English language and translation skills, providing psychological help (e.g., student-instructor communication, giving moral support, feedback, reading simplified self-help books, watching motivational videos), and developing students’ pragmatic skills (goal setting, time management, study skills, presentation, and note-taking skills). In addition, it provides some strategies for effective teaching.
HEPATITIS DISEASES PREDICTION USING MACHINE-LEARNING TECHNIQUES
Authors: YUSUF Aminat , AKANDE Oyelola
Published: March 2022

The importance of research that contributes to the early diagnosis and management of lethal diseases is critical to society, and hepatitis is one of these killer diseases. Hepatitis is a life-threatening condition that develops when the liver becomes enlarged and injured. As a result, the primary goal of this article is to analyze the hepatitis dataset in order to accurately forecast outcome accuracy and dependability. Six machine learning classification methods: Support Vector Machines, Gaussian Naive Bayes, Logistic Regression, Decision Tree, K Nearest Neighbors, and Multiplayer Perceptron were tested on hepatitis dataset and a confusion matrix was plotted for each of the classification models. The accuracy, precision, and recall criteria were used to make the comparison. For each model, the accuracy was assessed using the root mean square value and mean absolute error. The selected algorithms, particularly the Multiplayer Perceptron (87%) and Logistic Regression (87%) algorithms, showed high accuracy rates. Furthermore, with a minimal root mean error of 0.35 and a minimal mean absolute error of 0.12 and 0.13, the two algorithms are the most dependable of all the methods
SPOT SPEED LIMIT STUDIES OF AGAIE-KATCHA-BARO ROAD AGAIE, NIGER STATE
Authors: Wada Surajo Abubakar , Labbo Muwaffaq Safiyan , Kenchi Abdulkadir Yunusa
Published: March 2022

The number of accidents in Nigeria increases relatively from year to year, despite the fact that there are many programs organized by the authority to reduce them. Several factors contribute to the occurrence of accidents. Some of which are human behavior, vehicles condition, weather conditions, road surfaces, and road alignments (vertical and horizontal curves). This research presents empirical research to estimate the 85th percentile operating speed limits. The speed data were obtained using a stopwatch on the selected location along the Agaie-Katcha-Baro Road Agaie, Niger State. Spot speed study was adopted as the method for the research. The method has successfully predicted the 85th percentile speed limit for the Agaie-Katcha-Baro Road Agaie, Niger State. It has established maximum and minimum speed limits for the road and has also shown how inexpensive and quick the stopwatch method is in conducting spot speed studies in Nigerian roads. The findings are hoped to provide a lasting solution towards the national design standard for the highway designer and planner to improving the consistency of geometric design elements of the two-lane highways.
STUDY ON LENGTH-WEIGHT RELATIONSHIPS AND REPRODUCTIVE BIOLOGY OF SYNODONTIS NIGRITA (VALENCIENES, 1840) IN KANGIMI RESERVOIR, KADUNA STATE, NIGERIA.
Authors: Dambo A. , Solomon S. G.
Published: March 2022

The length-weight relationships and reproductive biology of Synodontis nigrita was studied. Fish specimens were collected from fishermen catch at the landing site.  Estimated exponent (b) varied between 1.949 and 2.845 (2.3092±0.08). Correlation (0.915±0.01) between length and weight indicated a strong positive relationship. There were more females than males in the fish species, the difference was not significant (P>0.05). Male fish recorded gonadosomatic index range from 0.253±0.03 to 2.715±0.15 and 0.410±0.05 to 5.352±0.72 for females. The gonadosomatic index of the male fish was not significantly different from that of the female. Rainy months gonadosomatic index were significantly higher than the dry months (P<0.05). The fish was observed to exhibit negative allometric growth. The species investigated recorded higher values of GSI in the wet season indicating the breeding period of the fish.
AN INVESTIGATION OF CRIMES RATES USING CO-KRIGING AND INVERSE DISTANCE WEIGHTS IN KATSINA STATE, NIGERIA
Authors: Usman Umar , Suleiman Shamsuddeen , Bui Muhd A. , Yar'adua Idris Shamahuddeen
Published: March 2022

The aim of the study is to investigates and predict the spatial variability of crimes rates using Co-kriging and inverse Distance Weight (IDW) in ten (10) Selected Local Government in Katsina State. The reported crimes to the Katsina State Police Command Consists of grievous hurt and Wound, Cattle rustling, Rape, Kidnapping, Assaults, Stealing and Burglary. The data is collected from Criminal Investigations Department Unit in Katsina State Command from 2010 to 2019. The method applied for this study was Co- Kriging Model (CK) and Inverse Distance Weight (IDW) to test the fitted Variogram Model and Spatial dependencies of variables examined. The findings predicted that, from the study areas the crimes rates likely happen in Dantamba, Sheme, Dofar-Mato, Gunya, Dankar, Rubau, Sawai, Wurma, Birinya Tsakatsa, Dankamtsa, Gardawa, and Katsalle Villages in a long run. The results also confirmed that, high level of unemployed youth and poverty rate in the study areas have a positive impact on socio-economic factors that influenced the crimes rates. The study suggests Government should encourage the youth in such localities by providing social amenities, employment opportunities, Good education, access of Road, Nearby Police stations and police outpost should be provided in each study areas. Peaceful campaign programs on dangers of Drug abuse and Trafficking, Illegal sects and sensitization of the communities on the need for peaceful co-existence. The study suggests the Government to put more emphasis on border patrol especially Kaduna, Niger, Sokoto, and Zamfara to avoid the  such occurrence of crimes in the State and Local
PERFORMANCE OF SOYBEANS (GLYCINE MAX L.) AS AFFECTED BY PLANTING METHODS AND FERTILIZER TYPE IN 2018 AND 2019 RAINING SEASON AT BILLIRI, GOMBE STATE NIGERIA.
Authors: Madina Paul , Toho J. I. , Danlingi H. G.
Published: March 2022

A field experiments was carried out during the rainy season of 2018 and 2019 Tal, Billiri in Gombe state, Nigeria. The aim of the experiment is to investigate the performance of soybeans as affected by planting methods and fertilizer type. The planting methods were; Drill (50kg/ha), Dibbling (Transplanted at 25 x 75cm) and Broadcast (50kg/ha). Fertilizer used were; NPK (40kgN, 80kg P, 20kg K), SSP (20kg P) NPK/SSP (Combination of NPK and SSP at 50kg N, 100kg P and 20kg K) and Control.  The treatments were laid in a randomized complete block design with three replications. The treatments were combined to have 10 plots in a block with 1 meter between the block and 0.5 meters within the plots. During the research growth characters were measured, other character like days of 50% flower, days of maturity, number of pod per plant, seeds per pod, 1000 seed weight and seed yield were also recorded. All the parameters studies have significantly (P≤0.05) responded to the both planting methods and fertilizer effects, where dill method was observed to perform higher in both growth character and grain yield. NPK/SSP fertilizer was significant in both growth, yield related character and over-all yield. 2019 rainy season all shows significant difference (P<0.05) in growth, yield and related characters when compared to 2018 rainy season.  Based on the result obtained it can be suggested that the use of Dibbling methods of planting and the application of NPK at 50kg/ha and NPK/SSP (40kgN, 80kg P, 20kg K) fertilizer will
IMPROVING FRIENDS RECOMMENDATION USING FP-GROWTH ALGORITHM IN SOCIAL TAGGING SYSTEM
Authors: Usman Bukar Usman  , Umar Kabir
Published: March 2022

Social tagging system are web-based sites that store user’s keywords called tags, continue to receive signiﬁcant consideration in academic environment it became an interesting research topic, give good support for users to tag resources, communicate with friends as well as friend recommendation, due to increasingly acceptance of Web2.0. There is a constant growth in the number of users using social tagging. Friend recommendation is one of the most important aspects for overcoming information overloading problem and helps users to make choice. In this work we proposed improving friend recommendation using, to address the difficulty of tag ambiguities. The technique is consisted of the following stages: Apply FP-Growth algorithm to discovery the frequent events sets among the users, construct the combine trust graph, and then apply ant colony optimization Algorithm to joint trust graph to compute the optimal friend recommended through repetition. The results of our experiments on a Delicious dataset, using our model, precision improved in the range 0.1 % to 1.1 %, recall increased greatly in the range 21.85 % to 50.84 % and F2 increased in the range 31.31 % to 50.85 % approximately. When compared to other methods, the outcome demonstrates a significant improvement. For friend commendation in a social tagging system, the future approach is to apply various data mining methods, large scale datasets, and community detection.
AN INVESTIGATION OF CAUSAL RELATIONSHIPS BETWEEN GOVERNMENT REVENUE AND EXPENDITURE IN NIGERIA, USING ENGLE COINTEGRATION APPROACH
Authors: Abubakar Hussaini , Usman M. , Falgore J . Y. , Sani S. S. , Abubakar I. , Adamu K.
Published: March 2022

This paper investigated the direction of causal relation between Government Revenue and Expenditure in Nigeria using annual data from 1981 to 2020. To validate the existence of long-run and short-run relationships and short-run dynamics of the variables, an Engle Cointegration was employed to test for cointegration and estimate error correction. The hypotheses were examined using the Engle-Granger approach to cointegration. The models' empirical results show that there is bidirectional causality between government revenue and expenditures in Nigeria. This indicates that the government's revenue and expenditure decisions are decided jointly by the country's fiscal authorities. The findings point to the existence of a revenue-to-expenditure feedback system in Nigeria. In other words, both revenue and expenditure levels, affect each other in the Nigerian budgeting process. Therefore, greater tax levels are driven by higher spending levels, and vice versa. This paper recommends that Nigerian fiscal authorities with budget deficits should simultaneously increase revenues and cut expenditure in order to control their deficits
PROTEIN AND AMINO ACIDS PROFILE OF LIMA BEAN (PHASEOLUS LUNATUS) FOODS IN KADUNA STATE
Authors: Dankat Charity , Olumuyiwa Owolabi A
Published: March 2022

This study was conducted to determine the amino acids content of some lima beans (Phaseolus lunatus) foods in Kaduna state, so as to provide nutritional basis for increased utilization of lima beans as a value-added product in households. The foods include lima bean porridge, lima bean-benniseed and lima bean-hungry rice. These foods were subjected to proximate and amino acids analysis using standard procedures and analytical methods. Amino acid composition of lima bean-benniseed recorded higher content of essential amino acids leucine (6.97g/100g), lysine (7.10g/100g), methionine (2.60g/100g), threonine (3.81g/100g), and also had higher content of non-essential amino acids, tyrosine (3.45g/100g), alanine (4.54g/100g), serine (3.94g/100g), glutamic acid (12.94g/100g) and aspartic acid (8.68g/100g). Lima bean-hungry rice food had higher content of isoleucine (4.04g/100g), phenylalanine (4.13g/100g), tryptophan (1.26g/100g). Proximate composition shows that the protein content of lima bean-benniseed food (8.33%) and lima bean porridge (8.30%) were significantly (P<0.05) higher than lima bean-hungry rice food while lima bean-benniseed food had higher content of crude fat (13.46%), ash (2.28%) and crude fibre (4.09%) compared to other foods. The carbohydrate content (24.58%) of lima bean porridge was significantly (P<0.05) higher than other foods. The study shows that lima bean foods have a good nutritional profile therefore; increase in the consumption of foods prepared with lima beans could serve as an addition to food-based strategies used in decreasing malnutrition and its effects
EVALUATION OF THE LEVEL OF ECONOMIC EFFICIENCY OF IRRIGATED TOMATO PRODUCTION UNDER KANO RIVER IRRIGATION PROJECT, NIGERIA
Authors: Ahmed Bashir Sa'ad , Abdulsalam Zakari , Maiyaki Abdullahi  Damisa
Published: March 2022

The broad objective of the study was to evaluate the Level of Economic Efficiency of Irrigated Tomato Production under Kano River Irrigation Project, Nigeria. A multi-stage sampling techniques was used to select 213 irrigated tomato farmers. Primary data was used and were collected using well-structured questionnaire. Data collected were analysed using descriptive statistics such as frequency, percentages and data. The result of the analysis revealed that the average economic efficiency of the irrigated tomato farms was 67%. This indicates that irrigated tomato farms were economically inefficient. It can be concluded that all the three categories of irrigated tomato farms were economically inefficient with large irrigated tomato farms having the highest economic efficiency of 67% in the study area. It is therefore recommended that agricultural extension workers should be provided to disseminate research finding and educate irrigated tomato farmers on ways of improving their economic efficacy
Dinamika Pengembalian Pinjaman Koperasi: Perspektif Karakteristik Peminjam, Besarnya Pinjaman, Pendapatan Usaha dan Pengalaman Usaha
Authors: Sriyono Sriyono , Fajriati Oktavia
Published: March 2022

Abstrak. Masalah pengembalian pinjaman koperasi merupakan suatu bahasan yang menarik karena menentukan kelancaran dari berjalannya koperasi tersebut. Penelitian merupakan penelitian baru karena pembahasan yang dilakukan sangat lengkap. Penelitian ini bertujuan untuk mengetahui Pengaruh Karakteristik Peminjam, Besarnya Pinjaman, Pendapatan Usaha dan Pengalaman Usaha Terhadap Pengembalian Pinjaman Koperasi pada Koperasi Simpan Pinjam dan Koperasi Serba Usaha di Kecamatan Candi, Kabupaten Sidoarjo. Penelitian ini termasuk jenis penelitian kuantitatif. Sampel yang digunakan pada penelitian ini sebanyak 150 responden pada Koperasi Simpan Pinjam dan Koperasi Serba Usaha di Kecamatan Candi, Kabupaten Sidoarjo. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah purposive sampling. Pengumpulan data dilakukan dengan penyebaran kuesioner. Metode penelitian untuk menguji kualitas data menggunakan uji validitas dan realibilitas. Sedangkan untuk analisis data menggunakan SEM (Structural Equation Modeling) dengan software AMOS 24. Hasil penelitian ini menunjukkan bahwa karakteristik peminjam, besar pinjaman, pendapatan usaha dan pengalaman usaha berpengaruh positif dan signifikan terhadap pengembalian pinjaman Koperasi
Impact of Trust on Employees' Engagement: The Mediating Role of Conflict Management Climate
Authors: Alshaabani Ayman , Rudnák Ildikó
Published: March 2022

This study investigates the role of conflict management climate (CMC) as a mediator between trust and employees' engagement. The study surveyed international employees who work in Hungary. The study aimed to determine how perceived trust affects employees' engagement through CMC's mediating effects. 355 participants joined in filling the questionnaires. After collecting the data, hypotheses were tested all together in a mediation analysis to fulfil the study's objectives. The results indicated that trust and CMC are related to employees' engagement. The results also showed that CMC could partially positively mediate the relationship between trust and employees' engagement. The study highlighted the importance of having a positive trust and conflict management climate on employees' engagement. Furthermore, the results suggested depending more on CMC when trying to build higher engagement levels among employees.
Studying Small States: The role of security and strategy as concepts
Authors: Kristjánsson Jakob Þór
Published: March 2022

This paper examines small-state studies. It analyses the binary oppositions in small-state theory, power relation, the inherent vulnerability in small-state studies and how security and strategy influence foreign relations of a small state. It examines the asymmetrical relationship small states have with powerful states using Iceland as an example.
Frédéric Lassere, Anne Choquet, and Camille Escudé-Joffres, Géopolitique des Pôles. Vers une appropriation des espaces polaires ? (Paris: Le Cavalier Bleu, 2021)
Authors: Guitard Galadrielle Pommereau
Published: March 2022

The book “Géopolitique des Pôles.” subtitled “Vers une appropriation des espaces polaires?” (“Polar geopolitics. Towards an appropriation of polar spaces?”, author’s translation) written by Frédéric Lasserre, Anne Choquet and Camille Escudé-Joffres is a general public book describing geopolitical polar dynamics, responding notably to the “Arctic Scramble” narratives and similar discourses of a war on resources at the poles. The book states very clearly and from the beginning that the authors consider the risk of conflict to be over-exaggerated, and even unrealistic. Drawing on the academic background of the authors, the book presents a geographical, political and legal overview of both the Arctic and Antarctic regimes of governance in layman’s language.
Pharmacological Effects of Hyaluronic Acid on Osteoarthritis of Knee Joint
Authors: Haque Md Enamul , Haque Md Ariful , Ahmed Samil Uddin , Hasan Md Habibul , Imam Md Zafar , Awal Md Abdul
Published: March 2022

This longitudinal type of prospective study was carried out the clinical outcome of intra-articular Hyaluronic Acid injection in the management of mild to moderate osteoarthritis of knee joint. The sample size was 78 which was selected purposively. Partially structured questionnaire was used to collect data from the respondents by face-to-face interview. All efforts were made to collect data accurately. For open questions, the respondents were asked in such a manner way so that they could speak freely and explain their opinion in a normal and neutral way. Regarding age in group distribution of the respondents it was found that majority (47.4%) were in the age group of more than 61 years. The man monthly family income was 215431.21 ± 16898.112 Taka. About 41.0% were overweight, 14.1% had hypertension, 80.8% had multiple symptoms of osteoarthritis in knee joint, 94.87% had restricted range of motion. It was identified that 92.31% relieved pain by injections, 60.25% had satisfactory feeling after injections. The relationship between age group of the respondents was statistically significant (p<0.05; p<0.01) with side effect of injection, pain relief after injection, feeling of patients after injection. The relationship between BMI of the respondents was statistically significant (p<0.05; p<0.01) with pain relief after injection, feeling of patients after injection. The relationship between complications of injection was statistically significant (p<0.05; p<0.01) with systemic diseases of the respondents.
TAJ 2021; 34: No-2: 48-55
Peningkatan Kualitas Pengiriman Barang Melalui Sistem Door To Door
Authors: Nuryanto Nuryanto , Elyatuzaka Elyatuzaka , Ridho Anggit
Published: March 2022

Dalam proses pengadaan barang, berbagai kegiatan harus dilalui. Mulai dari lokasi dimana bahan baku itu dihasilkan diangkut ketempat pengolahan untuk menjadikannya bahan jadi yang selanjutnya didistribusikan kepada pelanggan yang tersebar diberbagai tempat harus dilakukan melalui secara efisien, tepat manfaat dalam waktu yang singkat agar harga produk dapat terjangkau oleh konsumen. Dengan demikian peran perusahaan pelayaran sangat penting untuk menunjang distribusi barang dan jasa dari satu tempat ke tempat yang lain.

PT Salam Pacific Indonesia Lines (PT SPIL)  Cabang Pontianak, merupakan salah satu industri pelayaran nasional yang menyediakan jasa pengiriman barang dengan pelayanan logistik sistem door to door,  telah melayani hampir seluruh pulau di Indonesia. Penelitian ini bertujuan untuk mengetahui peran dan tanggung jawab SPIL Cabang Pontianak dalam pelayanan pengiriman barang sistem door to door, dengan menggunakan metode deskriptif yang memusatkan perhatian pada masalah masalah aktual apa adanya,  diperoleh gambaran bahwa PT SPIL)  Cabang Pontianak menerapkan empat area logistik dalam aktivitas logistiknya, dengan sistem door to door service. Empat area logistik tersebut yakni order processing, transportation, material handling, dan facility network design.
Puncture vine (Tribulus Terrestris L.) in control of health and reproduction
Authors: Sirotkin AV , Kolesárová A
Published: March 2022

Tribulus terrestris, L. (puncture vine) have been used as a folk medicine for five thousands of years, but its targets, effects, their mechanisms and application requires further studies. This paper reviews the provenance, constituents and properties of Tribulus terrestris, L., its general physiological and health effects, as well as the currently available knowledge concerning its influence on male and female reproductive processes and their dysfunctions. Analysis of the available publications demonstrated the influence of Tribulus terrestris on a wide spectrum of targets and physiological processe and disorders. In particular, Tribulus terrestris can be a stimulator of male and female reproductive processes at the level of central nervous system, sexual behaviour, pituitary and gonadal hormones and their receptors, gonadal functions (including ovarian follicullogenesis and spermatogenesis), improvement of the quality and quantity of gametes (at least of sperm) and fecundity. This ability of puncture vine is applicable for the improvement of man’s sexual desire and sperm quality in vivo and in vitro, as well as of women’s libido, activation of women’s reproductive organs, fecundity, and treatment of infertility, especially that related to the polycystic ovarian syndrome.
Eye pupil – a window into central autonomic regulation via emotional/cognitive processing
Authors: Ferencová N , Višňovcová Z , Bona Olexová L , Tonhajzerová I
Published: March 2022

If the eyes are windows into the soul, then the pupils represent at least the gateway to the brain and can provide a unique insight into the human mind from several aspects. The changes in the pupil size primarily mediated by different lighting conditions are controlled by the autonomic nervous system regulated predominantly at the subcortical level. Specifically, parasympathetically-linked pupillary constriction is under the Edinger-Westphal nucleus control and sympathetically-mediated pupillary dilation is regulated from the posterior hypothalamic nuclei. However, the changes in the pupil size can be observed at resting state even under constant lighting, these pupillary changes are mediated by global arousal level as well as by various cognitive factors. In this context, autonomic pathways modulating changes in the pupil size in response to the different light levels can be influenced by multiple central descending inputs driving pupillary changes under steady lighting conditions. Moreover, as the pupillary response is involved in emotional (task-evoked pupillary dilation as an index of emotional arousal) and cognitive (task-evoked pupillary dilation as an index of cognitive workload) stimulation, it can be used to detect the impact of mutual subcortical and cortical structures (i.e. overlapping brain structures included in autonomic, emotional and cognitive regulation) on the pupillary innervation system. Thus, complex understanding of the baseline pupil size´ and pupillary dynamics´ mechanisms may provide an important insight into the central nervous system functioning pointing to the pupillometry as a promising tool in the clinical application.
Improving the Acetic Acid Fermentation of Acetobacter pasteurianus by Enhancing the Energy Metabolism
Authors: Song Jia , Wang Jun , Wang Xinyu , Zhao Hang , Hu Tao , Feng Zhiwei , Lei Zhi , Li Weizhao , Zheng Yu , Wang Min
Published: March 2022

Energy metabolism is important for cell growth and tolerance against environment stress. In acetic acid fermentation by Acetobacter pasteurianus, the correlation coefficients of acid production rate with energy charge and ATP content were 0.9981 and 0.9826, respectively. The main energy metabolism pathway, including glycolysis pathway, TCA cycle, ethanol oxidation, pentose phosphate pathway, and ATP production, was constructed by transcriptome analysis. The effects of fermentation conditions, including dissolved oxygen, initial acetic acid concentration, and total concentration, on acetic acid fermentation and energy metabolism of A. pasteurianus were analyzed by using the RT-PCR method. The results showed the high energy charge inhibited glucose catabolism, and associated with the high ethanol oxidation rate. Consequently, a virtuous circle of increased ethanol oxidation, increased energy generation, and acetic acid tolerance was important for improving acetic acid fermentation.