bluuebunny/crossref_metadata_2025 huggingface dataset:
The additive value of platelet-rich plasma to topical Minoxidil in the treatment of androgenetic alopecia: A systematic review and meta-analysis
Authors: Yao Jia , Zhu Lu , Pan Meier , Shen Liling , Tang Yanli , Fan Liping
Published: August 2024

Objective

It still needs to be determined if platelet-rich plasma (PRP) has any added advantage over Minoxidil in treating androgenetic alopecia. We reviewed randomized controlled trials (RCTs) comparing scalp injections of PRP plus Minoxidil vs Minoxidil alone for managing androgenetic alopecia.

Methods

All RCTs published on Embase, Cochrane Library, and PubMed comparing PRP plus Minoxidil vs. Minoxidil alone were eligible. The literature search was completed on 5 March 2024. The review was registered on PROSPERO (CRD42024509826).

Results

Of five included RCTs, three had a high risk of bias, while one had some concerns. A systematic review of the studies showed that all trials reported better outcomes with PRP plus Minoxidil than with Minoxidil alone. Meta-analysis showed that hair density at one month (MD: 11.07 95% CI: 1.20, 20.94 I2 = 0%), three months (MD: 21.81 95% CI: 10.64, 33.00 I2 = 57%) and 5/6 months (MD: 17.80 95% CI: 7.91, 27.69 I2 = 80%) of follow-up was significantly better in the PRP plus Minoxidil vs the Minoxidil alone group. Meta-analysis of adverse events showed that the risk of adverse events was comparable in both groups (OR: 0.55 95% CI: 0.22, 1.36 I2 = 0%). The certainty of evidence on the GRADE assessment was "low to very low."

Conclusion

Very low-quality evidence shows that the addition of injectable PRP to topical Minoxidil may improve outcomes in patients with androgenetic alopecia. The addition of PRP was found to improve hair density and patient satisfaction significantly. However, the small number of studies with a high risk of bias and heterogeneity in PRP preparation methods are significant limitations of current evidence. Further studies with larger sample sizes and uniform PRP preparation protocols are needed.
The effect of ribociclib on the expression levels of miR-141 and CDK4/6-USP51 signaling pathway genes in MCF-7 and MDA-MB-231 cells
Authors: Baghermanesh Shayeste Sadat , Barati Mahmood , Hosseini Arshad
Published: August 2024

Introduction

Patients with breast cancer, especially triple-negative breast cancer, have a poor prognosis. There is still no effective treatment for this disease. Due to resistance to traditional treatments such as chemotherapy and radiation therapy, there is a need to discover novel treatment strategies to treat this disease. Ribociclib is a selective CDK4/6 inhibitor. Approximately 20% of patients with HR+ breast cancer developed primary resistance to CDK4/6 inhibitors, and more than 30% experienced secondary resistance. Since most patients experience resistance during CDK4/6 inhibitor treatment, managing this disease is becoming more challenging. Many malignant tumors abnormally express microRNA (miR)-141, which participates in several cellular processes, including drug resistance, proliferation, epithelial–mesenchymal transition, migration, and invasion.

Materials and methods

In the present study, we cultured MDA-MB-231 and MCF-7 cells in DMEM-F12 medium. By performing MTT assay we determined the cytotoxic effects of ribociclib on breast cancer cells, as well as determining the IC50 of it. Then, we treated the cells with ribociclib at two time points: 24 h and 72 h. After that, RNA was isolated and reverse transcribed to cDNA. Finally, we performed qRT‒PCR to evaluate how ribociclib affects the expression level of desired genes.

Results and conclusion

We found that ribociclib can inhibit cell growth in a dose- and time-dependent manner. We examined the mRNA expression of 4 genes. After ribociclib treatment, the mRNA expression of CDK6 and MYH10 decreased (p < 0.01, p < 0.05). The mRNA expression of CDON increased (p<0.05), but no significant changes were observed in ZEB1 mRNA expression. Furthermore, the qRT‒PCR results for miR-141 showed that the expression of miR-141 increased (p<0.01) after 72 h of treatment with ribociclib.
A neural network approach to predict opioid misuse among previously hospitalized patients using electronic health records
Authors: Vega Lucas , Conneen Winslow , Veronin Michael A. , Schumaker Robert P.
Published: August 2024

Can Electronic Health Records (EHR) predict opioid misuse in general patient populations? This research trained three backpropagation neural networks to explore EHR predictors using existing patient data. Model 1 used patient diagnosis codes and was 75.5% accurate. Model 2 used patient prescriptions and was 64.9% accurate. Model 3 used both patient diagnosis codes and patient prescriptions and was 74.5% accurate. This suggests patient diagnosis codes are best able to predict opioid misuse. Opioid misusers have higher rates of drug abuse/mental health disorders than the general population, which could explain the performance of diagnosis predictors. In additional testing, Model 1 misclassified only 1.9% of negative cases (non-abusers), demonstrating a low type II error rate. This suggests further clinical implementation is viable. We hope to motivate future research to explore additional methods for universal opioid misuse screening.
Separating the territory from the map: The intersection of cartography, memory and identity in autobiographical comics
Authors: Lombard-Cook Kat
Published: August 2024

Alison Bechdel said in an interview with Lynn Emmert that both maps and comics ‘take a complex or confusing three-dimensional reality and iron it out into a much more manageable two-dimensional version’. Yet the way maps weave together space, place, history, tradition and personal experience through multiple levels of signification points to anything but transparency of form, especially when deployed within autographics. We often encounter maps in autobiographical comics, where their uses can be as different as the lives they help to illustrate. When the layers of historical, cultural and personal references that intersect on the map plane are embedded in the formalist structures of comics, the levels of signification become multiplied – panel borders and topographical borders intersect, the geography of space merges with the geography of the page, and the subjectivity of the illustrated line overlays the objectivity of cartography. While the semiotic structures of maps and comics are presentationally different, both derive narratorial power from the relationships they make explicit through the marks on the page, and how their boundaries carve up space and time. Mapping traditions may be referenced to signpost authentication strategies within graphic memoirs. The structures of the map may be utilized – or even disrupted – in order to illustrate dynamics that cannot be signified through text or representational mimesis. This article will critically examine mapping modalities used in a variety of autographic narratives, focusing on the link between representation and experience of place for both the author and reader. By analysing what is included and excluded in a map, as well as the relationships the maps create between signifier and signified, we can draw some conclusions about how the mapmaker is positioning themselves within such frameworks as cultural background, socio-economic structures and hierarchies of knowledge.
Materiality and metalepsis in handmade small press alternative comics
Authors: Brookes Gareth
Published: August 2024

This article reconsiders the narratological theory of metalepsis in comics through a discussion of handmade small press publications. I will argue that material and formal elements can collapse categories through which metalepsis is theorized. I will give examples of cases in which traces of the author’s body coexist on the object of the comic through both mechanical reproduction and artisanal intervention and argue that this undermines binary metaphors such as ‘descending/ascending’ and ‘inside/outside’ through which metaleptic incursions from and into storyworld are understood. I will argue that material aspects, as well as production and distribution contexts, have been under-considered in formulations of metalepsis in comics, and that consideration of these aspects helps us rethink the role that the body of the author and reader play in metaleptic encounters.
Determinantes de la intención de uso de servicios FinTech
Authors: Amenabar Gómez Karen Eliana , Bruno Antonella , Comba Leandro , Graselli Natalia Cecilia
Published: August 2024

El presente estudio consiste en una investigación cuantitativa que tiene como objetivo identificar los determinantes más relevantes de la intención de uso de servicios FinTech. El mismo toma como base los constructos propuestos por la Teoría Unificada de Aceptación y Uso de la Tecnología e incorpora tres constructos adicionales para obtener una comprensión más amplia de los consumidores argentinos.
En esta investigación, se trabajó con una base primaria de datos obtenidos sobre una muestra de personas pertenecientes a las generaciones X y Millennial, residentes de la ciudad de Córdoba y su área metropolitana. Sobre dichos datos se aplicaron técnicas de análisis estadístico para lograr una comprensión acabada de los mismos, un análisis de clusters con el fin de segmentar a los consumidores y, finalmente, una regresión lineal múltiple para analizar la influencia de los constructos en la intención de uso.
Los resultados obtenidos indican que los constructos estudiados tienen un efecto significativo en la intención de uso de servicios FinTech, siendo la Capacidad de Respuesta el más influyente sobre esta variable. Por otro lado, se observaron diferencias significativas entre las generaciones en cuanto sus preferencias y necesidades. Finalmente, a partir de los datos obtenidos se identificaron tres perfiles de consumidores, que permiten formular estrategias de marketing.
El valor de este trabajo reside en aportar conocimientos sobre una actividad que se encuentra en expansión, además de proveer información relevante para los profesionales del marketing que trabajan en el sector de servicios FinTech, que les permitirá desarrollar estrategias efectivas para captar clientes.
PEMANFAATAN BOTOL BEKAS UNTUK MEDIA TANAMAN HIDROPONIK DI KELURAHAN BAMBU KUNING KOTA PEKANBARU
Authors: Rini Nizar  , Seprita Lidar  , Khairunnas Khairunnas
Published: August 2024

Plastic bottle waste is one type of inorganic waste that is difficult to decompose naturally. The use of this bottle is increasing and most of it comes from households. This waste if not managed properly will have an impact on the environment, but if used properly it will have added value. This was requested by head mother of RW 01 Bambu Kuning Village, utilizing plastic bottle waste into useful and value-added products. The purpose of this activity is to increase the knowledge and skills of housewives about recycling plastic bottle waste as a planting medium for hydroponic cultivation so that it can contribute to environmental cleanliness. This community service activity is carried out by (ABCD) Asset Based Community Development. This activity involved the Lecturer Team of the Faculty of Agriculture, Lancang Kuning University, hydroponic practitioners and administrators of the women's group in the neighborhood in RW 01, Bambu Kuning Village. This activity succeeded in increasing the knowledge and skills of hoisewives in hydroponic cultivation using bottle waste.
PENDAMPINGAN LEGALITAS USAHA, SPP-IRT, DAN SERTIFIKASI HALAL PRODUK UMKM DESA PAGELARAN, KECAMATAN MALINGPING, LEBAK, BANTEN
Authors: Jameelah Maryam , Komalasari Ema , Diandra Azzahra Putri , Giovanni Sarah , Yunus Efendi
Published: August 2024

Business legality is one of the important things that becomes one of the foundations of legal certainty for Small and micro-scale enterprises. Many businesses are reluctant to register their business due to the complexity of the process. This phenomenon is the main problem in areas far away from the city. Pagelaran Village has various kinds of dry and wet-based food products that are widely traded and become local specialties, unfortunately, most of them are traded without a clear food label, and do not yet have business legality, SPP-IRT, and halal certificates. Mentoring activity is carried out using the interview method, filling the documents, and socializing various important matters related to business legal aspects. Based on the results of the mentoring activity, it can be seen that the mentoring process succeeded in achieving a 100% success rate for managing business legality, having food labels, and having SPP-IRT numbers. In addition, 50% of business actors are known to have obtained halal certificates for their products. This mentoring activity is expected to contribute to increasing the competitiveness of MSMEs in Indonesia.
AKTIVASI GEN-Z TERHADAP PENGEMBANGAN UMKM MELALUI DIGITALISASI
Authors: Ramdhani Ahmad Thoriq Akhsan , Agung Rashif Madani
Published: August 2024

Micro, Small, and Medium Enterprises (MSMEs) play a vital role in the national economic growth, contributing significantly to the Gross Domestic Product (GDP) and employment. However, access to financial resources and markets remains a challenge for MSMEs, especially those operating in the Moyudan Subdistrict. This research aims to analyze the role of Generation Z in addressing these challenges through the digitalization of MSMEs. This study is a qualitative descriptive research that involves observations and the collection of primary and secondary data. The research findings reveal that Generation Z plays an innovative role in the development of MSMEs through digitalization. Through digital transformation, MSMEs can enhance their visibility and efficiency through e-commerce platforms and online promotions. This digital transformation is supported by the high internet penetration and social media usage in Indonesia. The government also plays a role in developing digital skills among Generation Z through various programs. Digitally savvy Generation Z individuals can actively contribute to the growth of MSMEs, as seen in the success of the "KKN Konversi" event in marketing Moyudan's MSME products. As seen in the results of this research, the role of Generation Z can be a hope for the progress of MSMEs in the Mayudan Subdistrict region.
Age-Specific Fertility Structure of Urban and Rural Populations in Post-Soviet Russia: Regional Panel Data Trends
Authors:   Economic Research Institute FEB RAS, Domnich Yegor
Published: August 2024

The age model of fertility in post-Soviet Russia is constantly changing. The general trend here is an increase in the average age of motherhood, but age-related fertility patterns are subject to spatial and temporal differentiation. The study, based on a panel regression analysis of time trends, determined the average rate of change in age-specific fertility rates for the most important 5-year age groups of women living in urban and rural areas, in a spatial and temporal context for 79 regions in 1993–2022. It has been established that the transition to the age structure of fertility characteristic of developed countries, when the postponement of childbearing at a young age is compensated by its increase in maturity, in post-Soviet Russia is valid only for the urban population, while rural population does not have such compensation. Regardless of the grouping of regions, age, intertemporal and rural- urban differences in the dynamics of fertility were revealed. Regional peculiarities of women’s reproductive behavior have been identified, which are consistently reproduced in several age groups and time periods
Modern Experience of Implementation of Regional Demographic Policy in the China Liaoning Province
Authors:   Institute for Demographic Research FCTAS RAS, Makeeva Svetlana
Published: August 2024

One of the current vectors of China’s regional policy, implemented in the northeastern province of Liaoning, is the demographic vector. The purpose of the article is to consider the modern experience of implementing regional demographic policy in the context of a comprehensive socio-economic revival of the province, as well as a reduction in the size and aging of the population of the North-East of China. The quantitative characteristics of the demographic development of Liaoning Province for 2020–2023 are characterized, the features of the formation and implementation of regional demographic policy, including at the municipal level, are determined, using the example of the city of Shenyang
Abordaje integrado del consumo de Cannabis: investigación, prevención y tratamiento
Authors: Fraga Ares Jaime
Published: August 2024

El consumo de cannabis en España es significativo, involucrando a personas de entre 15 y 64 años. En 2022, el 40,9% de los españoles había probado el cannabis alguna vez, y el 10,6% lo consumió en los últimos 12 meses. Aunque el consumo ocasional es estable, el consumo diario aumentó del 1,7% en 2007 al 2,8% en 2022. Los jóvenes de 15 a 24 años muestran una mayor prevalencia, con un 22,6% reportando consumo en el último año. El consumo es más común entre hombres (14,4%) que entre mujeres (6,8%). En 2022, el 1,9% de la población de 15 a 64 años (aproximadamente 600.000 personas) tuvo un consumo problemático de cannabis. Sin embargo, entre aquellos que han consumido cannabis en los últimos 12 meses y han contestado la escala CAST, la prevalencia de consumo problemático se sitúa en el 21,5%. En 2021, 12.338 personas iniciaron tratamiento por abuso o dependencia de cannabis, la mayoría hombres y muchos menores de 18 años. Las urgencias hospitalarias relacionadas con el consumo de cannabis no médico aumentaron, representando el 44,5% de los episodios de urgencia en 2021. De los 6.209 episodios de urgencias por sustancias psicoactivas, el cannabis estuvo involucrado en el 44,5% y la cocaína en el 40,3%. Este incremento ha sido notable desde 1996. El presente libro investiga cómo se ha llegado a este punto, señalando el papel de los movimientos pro-legalización y la industria del cannabis en la propagación del consumo. Estos movimientos, respaldados por la industria, han difundido la idea de que el cannabis tiene beneficios terapéuticos y que su consumo recreativo es inofensivo, lo cual es un mensaje engañoso que ha calado especialmente entre los jóvenes. El presente compendio está dividido en tres secciones y 18 capítulos, redactados por expertos en conductas adictivas. Proporciona un análisis basado en la evidencia científica más reciente sobre el consumo de cannabis, abarcando su incidencia desde una perspectiva epidemiológica y de salud pública, así como su tratamiento clínico-terapéutico. Además, se exploran las complejidades del consumo desde una perspectiva de género, ofreciendo una visión completa del fenómeno en la sociedad contemporánea.
Aktivitas Anticendawan Ekstrak Kecombrang Terhadap Colletotrichum acutatum pada Cabai Rawit
Authors: Imaniasita Vidya , Wiyono Suryo , Damayanti Tri Asmira
Published: August 2024

Kecombrang (Etlingera elatior) merupakan tanaman rempah tradisional yang banyak dimanfaatkan sebagai antimikrob dalam dunia medis di Indonesia. Namun, potensi kecombrang sebagai fungisida nabati dalam fitopatologi perlu dikaji lebih lanjut. Penelitian bertujuan menguji aktivitas anticendawan ekstrak rimpang dan daun kecombrang dalam pelarut metanol dan etanol terhadap Colletotrichum acutatum. Pengujian secara in vitro ekstrak kecombrang dilakukan dengan teknik peracunan medium dengan lima taraf konsentrasi. Parameter yang diamati diameter koloni, sporulasi, dan perkecambahan konidium. Pengujian secara in vivo dilakukan pada buah cabai rawit dengan parameter yang diamati masa inkubasi, insidensi dan keparahan penyakit, serta keefektifan perlakuan. Di antara konsentrasi yang diuji, ekstrak metanol daun kecombrang pada konsentrasi 2.5% menunjukkan konsentrasi paling baik dalam menekan pertumbuhan, sporulasi dan perkecambahan konidium C. acutatum dengan keefektifan berturut-turut 66.2%, 99.8%, and 100% dibandingkan perlakuan lainnya. Pengujian secara in vivo pada buah cabai rawit menunjukkan ekstrak metanol daun kecombrang pada konsentrasi 2.5% mampu menghambat pertumbuhan C. acutatum, sedangkan pada konsentrasi 4.8% mampu memperpanjang masa inkubasi, menurunkan insidensi dan keparahan penyakit secara nyata dengan keefektifan berturut-turut 88.4% dan 96% dibandingkan kontrol dan perlakuan lainnya. Aktivitas anticendawan ekstrak metanol daun kecombrang terhadap infeksi C. acutatum disebabkan kandungan senyawa fenol yang tinggi. Penelitian ini membuktikan potensi ekstrak metanol daun kecombrang sebagai fungisida nabati yang mampu menekan infeksi C. acutatum khususnya pada buah cabai rawit pascapanen.
Effect of Planting Media Modification on Seed Growth and Development of Three Mangroves Species from Jakarta and Kebumen, Indonesia
Authors: Ardli Erwin Riyanto , Hanifah Wahdini , Prabowo Romanus Edy , Nafis Bayu Ashila , Widyartini Dwi Sunu
Published: August 2024

The rehabilitation of mangroves depends on the availability of high-quality, sufficiently prominent seeds. Currently, a lot of mangrove nursery activities continue to employ traditional techniques, which results in low-quality and slowly growing seedlings. The mangroves of Jakarta were selected because they represent a heavily polluted mangrove ecosystem on Java's northern coast, whereas the mangroves in Kebumen, on Java's southern coast, are in the opposite situation. This study proposed to find an approach to supply Indonesia's mangrove restoration projects with adequate seeds. An experimental approach with a complete randomized design and a factorial pattern was used. The variables tested were planting media and three kinds of mangroves: Rhizophora mucronata, Ceriops tagal, and Bruguiera gymnorrhiza. Mangroves from Jakarta are treated with mud, soil media, or a mix of them. A mixture of mud, husk, and husk charcoal is used for six treatments planting media for mangroves from Kebumen. The mangrove seedlings' growth, biomass, and chlorophyll content are the dependent variables. ANOVA was used to evaluate the data with a 95% confidence level, and Duncan's comparison of means test followed. The growth of mangrove seedlings was discovered to be impacted by media type, while the chlorophyll content, dry biomass of roots, stems, and leaves were not affected by this factor. Three species of mangroves differ regarding growth rate, biomass of roots, stems, and leaves, and chlorophyll content. In order to support Indonesia's efforts to rehabilitate mangroves, this research can offer understanding regarding how to select and employ the best media to effectively produce high-quality seeds.
Can Two Opposing Narratives Be Equally Valid? Reflections on Zreik’s Reflections on the War in Gaza
Authors: Heyd David
Published: August 2024

The article critically examines the arguments of Raef Zreik regarding the 2023 war in Gaza. It first analyzes the use of the concept of narrative in defending political causes and actions. It shows that due to their subjective nature two opposing narratives can be equally valid as long as they satisfy conditions of internal coherence and fidelity to the facts. It then shows that Zreik’s argument of ‘fragmentation’ is double edged and cannot be used for laying full responsibility on Israel. It then proceeds to criticize the claim that Zionism is a colonialist enterprise and shows that Zionism does not consist of all the basic characteristics of colonialism. Finally, it analyzes the common argument of self-defense as the only justification of starting a war and shows the limitation of such an argument in a theory of war, mainly because in most wars both sides have the right to defend themselves, including the allegedly unjust party. All that remains after showing the weakness of most arguments for this or that side to the conflict is the conclusion that compromise is the only way out of the deadlock, having the virtue of being pragmatic rather principled.
Impact of high-speed railway network on county-level accessibility and economic linkage in Jiangxi Province, China: A spatio-temporal data analysis
Authors: Wu Lei , Song Xiaodan , Yin Feng
Published: August 2024

High-speed railway (HSR) networks have profoundly influenced interregional accessibility and economic linkages. This study examined 100 counties (cities) and districts in Jiangxi Province, using spatial and temporal data to measure weighted average travel time, daily accessibility, the accessibility coefficient, and the total and intensity of economic linkages. This study analyzed the impacts of operating a single HSR line versus an entire network. The findings revealed that (1) the HSR network has created a balanced spatial–temporal convergence effect, narrowing the gap between most locations and showing a clear “corridor effect”; (2) the network has strengthened economic connections among counties and has significantly enhanced overall economic output by creating two high-level economic linkage belts, formed around the Shanghai–Kunming and Beijing–Hong Kong HSRs; and (3) the network amplifies the “Siphon effect” and “Matthew effect,” further disadvantaging non-connected regions. Therefore, the province should promote a well-designed, HSR network, enhancing economic exchanges among counties and fostering a high-level economic belt characterized by diversity, complementary advantages, and coordinated development.
Between Shenguai and Science: The Visual Imagination of Technical Objects in Republican China
Authors: Wang Yuhui
Published: August 2024

This article first examines the technical objects in three Chinese graphic novels (lianhuanhua) during the Republican era: Scientific Investiture of the Gods (Kexue fengshenbang), Scientific Demon King (Kexue mowang), and Black Bat (Hei bianfu). I regard the visual construction of technical objects in these works as a prehistory of Chinese-styled science fiction films between the 1930s and 1940s. I argue that early Chinese science fiction films share the same resources of traditional shenguai xiaoshuo with these graphic novels in Republican China. Scrutinizing the information about several early Chinese science fiction films, I locate the visual imagination of technical objects in the context of Chinese art history combined with local and imported conventions. I attempt to answer the following questions about the visual construction of technical objects in Republican-era artworks: how does the visual tradition of shenguai xiaoshuo connect to graphic novels and films in Republican China? To what degree could the hybrid modernity of shenguai combined with Hollywood films become a unique legacy for visualizing the technical objects in Chinese science fiction arts?
Performance analysis of quantum harmonic Otto engine and refrigerator under a trade-off figure of merit
Authors: Kaur Kirandeep , Rebari Shishram , Singh Varinder
Published: August 2024

We investigate the optimal performance of the quantum Otto engine and refrigeration cycles of a time-dependent harmonic oscillator under a trade-off figure of merit for both adiabatic and nonadiabatic (sudden-switch) frequency modulations. For heat engines (refrigerators), the chosen trade-off figure of merit is an objective function defined by the product of efficiency (coefficient of performance) and work output (cooling load), thus representing a compromise between them. We obtain analytical expressions for the efficiency and coefficient of performance of the harmonic Otto cycle for the optimal performance of the thermal machine in various operational regimes. Particularly, in the sudden-switch regime, we discuss the implications of the nonadiabatic driving on the performance of the thermal machine under consideration and obtain analytic expressions for the maximum achievable efficiency and coefficient of performance of the harmonic Otto thermal machine. Particularly, we show that the quantum harmonic Otto cycle driven by sudden-switch protocol cannot work as a heat engine or refrigerator in the low-temperature limit. Finally, we show that in the high-temperature limit, the frictional effects give rise to a richer structure of the phase diagram of the harmonic Otto cycle. We identify the parametric regime for the operation of the Otto cycle as a heat engine, refrigerator, accelerator, and heater.
Design of optical Kerr effect in multilayer hyperbolic metamaterials
Authors: Genchi Domenico , Dodici Francesca , Cesca Tiziana , Mattei Giovanni
Published: August 2024

The design of optical materials in nonlinear devices represents a fundamental step for their optimization and miniaturization, that would significantly contribute to the progress of advanced nanophotonics and quantum technologies. In this work, the effect of geometry and composition of multilayer hyperbolic metamaterials on their third-order nonlinear optical properties, i.e. the optical Kerr effect, is investigated. One figure of merit is provided to be used as a predictive tool to design and best exploit the local intensity enhancement in low-loss metamaterials to be used for various applications in nonlinear nanophotonics.
Review of gliding arc plasma assisted ignition and combustion for gas turbine application
Authors: Gong Ka , Liu Yibo , Zhao Honghua , Wang Zhikai
Published: August 2024

The potential of gliding arc plasma-assisted ignition and combustion technology to enhance ignition and combustion performance is attracting increasing attention from the scientific community. A multitude of experimental studies have been conducted by scientists and engineers on its application in gas turbine combustors. This paper presents a review of the research conducted on gliding arc plasma-assisted ignition and combustion over the past five years. Gliding arc plasma exerts a multitude of effects on combustion processes. These effects can be broadly categorized as follows: (1) reduction in ignition delay time; (2) expansion of ignition and lean blowout boundaries; (3) enhancement of ultra-lean burning combustion and low-temperature flame stability; (4) improvement in combustion efficiency; (5) reduction in pollutant emissions; (6) augmentation of stability of unstable fuels such as ammonia. Finally, a prospection on the application of gliding arc plasma assisted ignition and combustion technology in gas turbine combustor is presented.
Memória, imprecisões, sentidos
Authors: Sobral Adail , Giacomelli Karina
Published: August 2024

Pretendemos, neste ensaio de discussão teórica, a partir de considerações sobre memória e produção de sentido, apresentar uma breve discussão sobre as imprecisões, flutuações, modulações etc. que caracterizam o uso da linguagem. Para isso, levamos em consideração, de um lado, a imprevisibilidade que marca as interações (as interações não têm delimitação precisa; dependem de eventos que não se podem prever), e, do outro, a parcialidade constitutiva do trabalho da memória nas interações. Nesses termos, a memória é um esquecimento seletivo, no sentido de que o sujeito recorre ao repertório de rememorações de acordo com as necessidades, imprevisíveis, de suas interações. Trata-se de um trabalho que se inspira na teoria e análise dialógica, ou análise dialógica do discurso, a qual permite defender a existência de dispositivos enunciativos de mediação entre repertório linguístico e agir discursivo. Não vamos reapresentar aqui a teoria dialógica, uma vez que fazemos uma discussão epistemológica de aspectos seus, e não um artigo baseado em obras específicas daquela. De acordo com essa teoria, as significações na língua são mobilizadas para instaurar sentido na linguagem. As significações se manifestam em frases e, o sentido, em enunciados. A mobilização das significações, que têm um maior grau de estabilidade, pelos enunciados, a fim de criar sentidos, é afetada, como pretendemos mostrar, pelas instabilidades manifestas nas interações, mesmo que estas se realizem em gêneros, que têm uma estabilidade relativa, mas que não são elementos capazes de delimitar de uma vez por todas o que ocorre no processo de instauração de sentidos.
A voz do aluno
Authors: Freire Dorow Cloris
Published: August 2024

O presente artigo aborda a questão do poder exercido pela escola sobre os corpos, como forma de comandar, de moldar, de modificar, tendo como materialidade discursiva o discurso de dois alunos e uma aluna do grupo “Ocupa”, material obtido através de gravação de entrevista realizada pelos alunos. Este grupo surgiu como uma forma de se opor à reforma do ensino médio, promulgada pelo governo atual, sem a devida consulta aos principais envolvidos, discentes e docentes. A vertente teórica, que embasa esta discussão, é a Análise de Discurso francesa. No discurso escolhido, observou-se que o dizer dos alunos, mesmo lutando por direitos que lhe seriam concernentes, reproduz formações discursivas que demonstram dizeres prenhes de autoritarismo, advindos do discurso pedagógico. Também se pôde observar alguns aspectos que sobressaem na argumentação: as formações imaginárias que tentam prever quem é o interlocutor, assim como aspectos prosódicos como: pausas, silenciamentos que trazem para os dizeres outros sentidos.
Promoter mutation-independent TERT expression is related to the immune-enriched milieu in papillary thyroid cancer
Authors: Seo Dong Hyun , Lee Seul Gi , Choi Soon Min , Kim Ha Yan , Park Sunmi , Jung Sang Geun , Jo Young Suk , Lee Jandee
Published: August 2024

Telomerase reverse transcriptase promoter mutation (pTERT MT) promotes human carcinogenesis via aberrant expression of telomerase reverse transcriptase (TERT). However, the tumorigenic impact of TERT expression independent of pTERT MT remains unclear despite numerous mechanisms of TERT being suggested. To tackle this issue, we employed comprehensive bioinformatics to assess biological variations noticed among different TERT expression mechanisms. Papillary thyroid cancer (PTC) with pTERT MT (pTERT MT PTC) presented aggressive clinical behavior and exhibited biological profiles associated with cellular immortality and genomic instability. PTC with TERT expression but without pTERT MT (TERT (+) PTC), also exhibited poor clinicopathological characteristics and was enriched with immune responses. In accordance, c-MYC/E2F and nuclear factor kappa B (NFκB) were dominant transcription factors in pTERT MT PTC and TERT (+) PTC, respectively. Notably, we revealed TERT hypermethylated oncological region (THOR) as a potential TERT expressing mechanism in TERT (+) PTC patients. Furthermore, three unique subtypes of papillary thyroid cancer were deciphered using a combination of machine learning-based scoring systems. Our proposed scoring system was clinically significant, especially in microcarcinoma, predicting survival outcomes and inferring therapeutic responses to radioactive iodine therapy. Finally, our analysis was expanded to endocrine-related cancers, unveiling various regulatory mechanisms of TERT with poor clinical outcomes and biological behaviors.
Endocrine immune-related adverse events by immune checkpoint inhibitors and potential predictive markers: a prospective study from a single tertiary center
Authors: Barlas Tugba , Sutcuoglu Osman , Akdogan Orhun , Balos Toruner Fusun , Akturk Mujde , Ozdemir Nuriye , Yazici Ozan , Eroglu Altinova Alev
Published: August 2024

Immune checkpoint inhibitors (ICIs) can trigger immune-related adverse events (irAEs). The appearance pattern of irAEs, who is prone to them, and their mechanisms are still uncertain. In this study, we aimed to monitor patients initiated on ICIs for endocrinological aspects and to investigate the potential predictive markers in the development of endocrine-irAEs. The study prospectively included 43 patients with metastatic disease scheduled for anti-PD-1/L1 therapy. Endocrinological follow-up was conducted at specified intervals as well as in response to any additional reported complaints. Serum concentrations of CXCL10, IL-1beta, and IL-17A were measured prior to ICI and during the endocrine-irAEs. A total of 39.5% of the patients experienced endocrine-irAEs, with a median onset time of 3 months. Among patients, 34.9% developed thyroid-related adverse events, and 4.6% experienced hypophysitis. Thyroid autoantibodies were associated with a higher incidence of thyroid-related irAEs (P = 0.004). In the irAE group, median pre-ICI CXCL10 and baseline thyroid stimulating hormone (TSH) levels were significantly higher, baseline total testosterone level in men was lower than in the non-irAE group (P < 0.05), whereas IL-1beta and IL-17A levels did not differ (P > 0.05). Serum CXCL10, IL-1beta, and IL-17A concentrations did not differ significantly pre-ICI and during adverse events (P > 0.05). Pre-ICI CXCL10 concentration was correlated positively with anti-TPO levels in patients with at least one thyroid autoantibody positivity (r = 0.706, P = 0.01) and negatively with baseline total testosterone level of men (r = 0.509, P = 0.002). Our results suggest that higher pre-ICI serum CXCL10 and TSH levels might have a predictive role in the development of endocrinopathies. Besides, baseline thyroid antibody measurements could be beneficial in predicting thyroid dysfunction.
Jonas Rudmanas (1989 02 10 - 2010 09 08)
Authors: Prapiestis Juozas
Published: August 2024

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The manor estate economy ofthe Republic of Two Nations (the Polish-Lithuanian Commonwealth) in the 16th-18th centuries from the Marxist and neo-institutionalist perspectives
Authors: Žiemelis Darius
Published: August 2024

This article continues an analysis of the socioeconomic history of the Republic of Two Nations (RTN) in the 16th-18th centuries, viewed through two competing historiographical views: the traditional Marxist conception emphasizing internal considerations and the neo-Marxist capitalist world system theory (CWS) emphasizing external motivations. The questions addressed in this text arose from the conclusion of an earlier study (Lietuvos istorijos studijos, 2006, volume 18) that the agrarian structure of Eastern Europe in the 16th-18th centuries, according to the CWS conception, is similar in many respects to what Marxists call "feudalism" in Western Europe in the 11th-15th centuries (with the agrarian structure rather than political "superstructure" in mind). The point of this article is to define in more detail the structural similarities and differences between the Western European manor in the 11th-15th centuries and the Eastern European manor (especially in the RTN) in terms of Marxism and neo-institutionalism.
In reconstructing the economic structure of the Western European manor from the Marxist perspective in the first section of the article, the author employs a research performed by the school of E. A. Kosminsky, a renowned medieval expert in the Soviet Union. American economists of the new institutionalist economic history work by its best-known representatives D. C. North and R. P. Thomas inform the neo-institutionalist perspective in the first section. In the second section, the model of feudal economic function by one of the most renowned Polish economic historians, W. Kula, is used for reconstructing the manor economy of Eastern Europe (and especially the RTN) in the 16th-18th centuries from the Marxist perspective. The third section features the above-mentioned studies as well as additional literature (J. Topolski, A. Wyczanski, P. Gorecki, K. Glamann, E. J. Hobsbawm, S. Pamerneckis and others), to illustrate in detail for the first time in historiography and expand upon, the structural similarities and differences between the Western European manor in the 11th-15th centuries and the Eastern European manor in the 16th-18th centuries according to both of the aforementioned perspectives.
Arguments are put forward for the thesis that the manor economy of the 16th-18th centuries in the RTN, affected by Western Europe's developing capitalist relationships, can be qualified neither as a typical feudal economy (which the Western European manor of the Middle Ages should properly be considered) nor as a typical capitalist enterprise. The RTN manor of the 16th-18th centuries was an economy based on the total domination by the lord of the peasants oriented to the production of mercantile goods, as one of the forms used by the lord for accumulating capital.
How the approach to the Epoch of the Grand Duchy of Lithuania is changing in the Lithuanian Historiography today?
Authors: Jarutis Vytautas
Published: August 2024

The aim of the article is to evaluate the methodological and ideological developments in the historiography of the epoch of the Grand Duchy of Lithuania in the comparative perspective of the last century. Methodologically, "the Golden Age" is exactly recorded at present in the Lithuanian historiography of the Grand Duchy of Lithuania. After reestablishing independence in 1990, Lithuanian historians refused the heritage of Soviet historiography, started integrating the Western theoretical discourse and have created a unique model of the development of the Grand Duchy of Lithuania in the European civilization, proposed by Edvardas Gudavičius. The receptions and transformations of this paradigmic model have been continuing until now in the transition from the political history to the history of society and everyday life, from an ethnolinguistically monoperspective to the liberal multicultural great narrative. Ideologically, the developments in the Lithuanian historiography of the Grand Duchy of Lithuania are analyzed on the basis of nowadays' comparative studies of nationalism. This allowed to uncover the ethnocultural positions of interwar Lithuanian historians, the intuitionalism of the Soviet times and the constructivism of today, which implicate the cognitive step from "the plough of the nation" to the "Lithuanian europeism" in the Lithuanian collective consciousness.
Some Remarks after the lnternational Conference "Žalgiris- Grunwald-Tannenberg 1410: War and Peace in the late Middle Ages"
Authors: Volungevičius Vytautas
Published: August 2024

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Mathematical endeavours to explain biological phenomena
Authors: Kllogjeri Adrian , Kllogjeri Pellumb
Published: August 2024

The use of mathematical methods and models is continually increasing in many areas of contemporary biological research: in genomics, molecular modelling, structural biology, neurobiology, biology of systems and so on. In this paper we discuss the importance of Mathematics, mathematical modelling and dynamic visualization, with the aid of technology, in the field of Biology and Medicine. We emphasize that the language of Mathematics and the graphical display is remarkably powerful and flexible, and the modes of understanding and thinking about phenomena can yield deep insight into it that pervades the modern life.
Моделі та методи оптимального покриття областей довільної форми: теорія та практичне застосування
Authors: Яковлев Сергій Всеволодович
Published: August 2024

У доповіді наведено результати перспективних досліджень у галузі математичного моделювання просторових конфігурацій, оптимізаційних методів геометричного покриття та приклади їх практичного застосування. Дослідження задач покриття складних областей об’єктами довільної форми має міждисциплінарний характер і ґрунтується на сучасних досягненнях математики, комп’ютерних наук, інформаційних технологій та штучного інтелекту. Такі задачі є складовою рішень широкого кола завдань, пов’язаних із різними системами моніторингу територій, логістики, зв’язку, розвитком регіональної та критичної інфраструктури тощо.
“O direito vive da exceção”
Authors: Cunha Leitão Macell
Published: August 2024

Este artigo tem o objetivo de analisar o funcionamento da máquina jurídico-política de acordo com o pensamento de Giorgio Agamben. Partindo da releitura dos fundamentos do Estado como uma relação jurídica de abandono, o trabalho desenvolve a hipótese de que “o direito vive da exceção”, entendendo essa formulação no duplo sentido de que a exceção origina a ordem jurídica podendo também findá-la e, ao mesmo tempo, constitui o seu modo normal de aplicação. À luz da filosofia agambeniana, a máquina jurídico-política opera através da articulação entre auctoritas e potestas; contudo, ao fazer coincidir autoridade e poder, a modernidade permitiu que o estado de exceção, que articula os dois polos da máquina, se tornasse a regra. A contribuição do presente trabalho consiste em destacar como a suposta ineficácia das normas jurídicas, frequentemente interpretada como ausência do direito, é não apenas estrutural ao ordenamento jurídico, mas funcional para o governo dos corpos.
ASSESSING THE HEALTH OF REGIONAL DEVELOPMENT BANKS THROUGH CAMELS METHOD
Authors: El ISLAMI MUHAMMAD FATCHULLAH , IKBAL MUHAMAD
Published: August 2024

Using the CAMELS method, this study aims to compare the health of two regional development banks, Bank Jatim and Bank Jateng. The findings will inform government regulations, internal bank policies, investor decisions, academic literature, and public savings choices. It employs a descriptive quantitative approach, analyzing financial statement data from 2017 to 2021. Bank Jatim demonstrates better health than Bank Jateng, particularly in asset quality, profit margin, liquidity, and market risk sensitivity. However, both banks share similar capital and management qualities. Unlike previous research focusing on large state-owned banks, this study prioritizes regional development banks in East Java and Central Java, aiming to offer insights into their health levels through CAMELS analysis.
QIULEA: Quantum-inspired ultra-lightweight encryption algorithm for IOT devices
Authors: AL-Khalisy Shatha H. Jafer , Abed Wafaa M. Salih , Al-Kateb Ghada , Aljanabi Mohammad , Mijwil Maad M. , Abotaleb Mostafa , Dhoska Klodian
Published: August 2024

This paper introduces a quantum-inspired ultra-lightweight encryption algorithm tailored for Internet of things devices with limited resources. The proposed algorithm excels in processing speed, memory usage, and energy efficiency, significantly outperforming existing lightweight cryptographic algorithms. With a processing speed of 12.4 ms, memory usage of 3.2 kilobytes, and energy consumption of 0.7 milli-Joules per kilobyte, the proposed algorithm stands out for its robust security and potential to enhance the security of Internet of things devices across various applications. This paper explores the methodology behind the proposed algorithm, comparing its performance metrics with conventional S-box generation approaches, and demonstrates its superiority in both theoretical and practical aspects.