bluuebunny/crossref_metadata_2025 huggingface dataset:
Untersuchungen zur Inhibition von Autophagie in FLT3-ITD-mutierten AML-Zellen
Authors:   , Hock Susanna
Published: November 2023

Aktivierende Mutationen der Fms-like tyrosine kinase (FLT3) treten bei 25 % der Patienten mit akuter myeloischer Leukämie (AML) auf und begünstigen die unkontrollierte Proliferation maligner Blasten. Autophagie ist ein intrazellulärer Prozess, durch den zytoplasmatische Bestandteile lysosomal abgebaut werden und fungiert als intrazellulärer Homöostase-Mechanismus unter Stress-Bedingungen. Ziel dieser Arbeit war es, herauszufinden, ob FLT3-ITD+-AML-Zellen vulnerabel gegenüber Autophagie-Hemmung sind. Hierzu wurde zunächst untersucht, wie sich FLT3-ITD-Signaling und Autophagie unter basalen Wachstumsbedingungen gegenseitig beeinflussen. In einem genetischen Modell zeigte sich, dass FLT3-ITD-transformierte wachstumsfaktorunabhängige Zellen während ihrer fortgesetzten Proliferation vermehrt Autophagie betreiben. Lysosomale Autophagie-Inhibitoren zeigten jedoch unter diesen Bedingungen keine erhöhte Wirksamkeit gegenüber FLT3-ITD-positiven Zellen. Humane FLT3-ITD-positive AML-Zellen zeigten nach genetischer Deletion von ULK1 ebenfalls nur transiente und milde Proliferationsdefizite. Unter basalen Wachstumsbedingungen zeigte sich also keine erhöhte Vulnerabilität FLT3-ITD-exprimierender Zellen gegenüber Autophagie-Inhibition. Daraufhin wurde die Bedeutung von Autophagie während pharmakologischer Hemmung von FLT3 untersucht. FLT3-Inhibition mittels AC220, einem FLT3-spezifischer Tyrosinkinase-Inhibitor, induzierte bzw. steigerte die autophagische Aktivität ähnlich stark wie eine direkte mTOR-Inhibition. Dies ließ sich im Zellmodell therapeutisch ausnutzen: eine Kombinationsbehandlung mit AC220 und einem lysosomalen Autophagie-Inhibitor zeigte eine synergistische antiproliferative Wirkung. Dies stellt möglicherweise einen neuen rationalen Kombinationsbehandlungsansatz für die Therapie FLT3-ITD-positiver AML-Patienten dar.
Effectiveness of Valsartan’s Single-Pill Combination Therapies on Blood Pressure Control in Hypertensive Patients: Malaysian Single-Centre Real-World Experience
Authors:   Cardiology Department, Institut Jantung Negara, Kuala Lumpur, Malaysia, Yusof Ahmad K. M. , Mohamad Halil Norhazreen ,   Cardiology Department, Institut Jantung Negara, Kuala Lumpur, Malaysia, Jaffar Norfazlina ,   Data Management and Biostatistical Support, Clinical Research  Department, Institut Jantung Negara, Kuala Lumpur, Malaysia, Sabian Intan Safarinaz ,   Data Management and Biostatistical Support, Clinical Research  Department, Institut Jantung Negara, Kuala Lumpur, Malaysia, Looi Zhi Ling ,   Medical Affairs, Novartis Malaysia, Selangor, Malaysia
Published: November 2023

Background: Uncontrolled hypertension can cause cardiovascular disease and is an important public health issue. Single-pill combination (SPC) therapies possess combined blood pressure (BP)-lowering effect and may improve compliance to treatment. This study assessed the effectiveness of valsartan (Val)-based SPC therapies in achieving BP control in hypertensive patients. Methods: This was a retrospective study. Data were extracted from the hybrid medical records of patients from the Institut Jantung Negara (IJN), Malaysia. Adults with established diagnosis of hypertension and on prescription of Val-based SPC therapies as part of routine medical care from 1 January 2013 to 31 December 2018, with ≥ 1 year of follow-up were included. Primary endpoint was proportion of patients achieving therapeutic BP control (BP < 140/90 mmHg). Secondary outcomes included change from baseline (CFB) in systolic BP (SBP) and diastolic BP (DBP), and subgroup analysis was based on baseline SBP categories and presence of diabetes. Results: Study included 409 hypertensive patients. The mean (standard deviation [SD]) age of the population was 65.1 (10.6) years old, with male predominance (61.6%). Proportion of patients achieving target BP between baseline and follow-up were 57.0% (P < 0.001). Mean CFB in SBP and DBP were recorded as 19.52 mmHg and 7.47 mmHg, respectively. Over half of the patients achieved the target BP in all subgroups categorised by SBP at baseline, except the subgroup of SBP 160 mmHg–179 mmHg. SPC therapies were continued in 97.3% of patients at 1-year follow-up. Conclusion: Patients using Val-based SPC therapies had significant reduction in BP with good tolerability, with 57% of patients achieving target BP over a prolonged 1-year follow-up period. Uptake of SPC therapy is warranted to improve patient care and outcomes in hypertension.
Potential Usefulness of Bacteriophages for the Treatment of Multidrug-Resistant Acinetobacter Infection
Authors:   Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Raees Fahad ,   Department of Microbiology, College of Medicine, Umm al-Qura University, Makkah, Kingdom of Saudi Arabia, Harun Azian ,   Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia,   Hospital Universiti Sains Malaysia, Kelantan, Malaysia, Ahmed Abdalla ,   Department of Microbiology, College of Medicine, Umm al-Qura University, Makkah, Kingdom of Saudi Arabia, Deris Zakuan Zainy ,   Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia,   Hospital Universiti Sains Malaysia, Kelantan, Malaysia
Published: November 2023

Bacteriophages were discovered in early 20th century. However, the interest in bacteriophage research was reduced with the discovery of antibiotics. With the increasing number of infections due to multidrug-resistant (MDR) organisms, the potential usefulness of bacteriophages as therapeutic agents has been re-evaluated. In this review, we found that more than 30 lytic bacteriophages that infect Acinetobacter species have been characterised. These are mainly members of Caudovirales, with genome sizes ranging from 31 kb to 234 kb and G+C contents ranging from 33.5% to 45.5%. The host range can be as low as < 10% of all tested Acinetobacter strains. Fourteen published murine trials indicated positive outcomes in bacteriophage-treated groups. Only two case reports were pertaining to the use of bacteriophages in the treatment of Acinetobacter infections in humans; in both cases, the infections were resolved with bacteriophage therapy. The use of bacteriophages has been associated with reduced Acinetobacter burden in the environment, as shown in two studies. The major limitation of bacteriophage therapy is its highly selective host strain. In conclusion, the potential usefulness of bacteriophage therapy for the treatment of MDR Acinetobacter species has been documented only in limited studies and more research is needed prior to its extensive use in clinical practice.
Electromagnetic Field Exposure and Abortion in Pregnant Women: A Systematic Review and Meta-Analysis
Authors:   Department of Midwifery, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran, Irani Morvarid ,   Health Sciences Research Center, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran, Aradmehr Maryam ,   Department of Midwifery, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran,   Health Sciences Research Center, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran, Ghorbani Mohammad ,   Health Sciences Research Center, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran, Baghani Roya ,   Department of Midwifery, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran
Published: November 2023

This study examined the effects of exposure to electromagnetic fields (EMF) on pregnancy and the risk of miscarriage. We performed a systematic search for relevant studies published to August 2021 in the medical databases of PubMed, CINAHL, Scopus, Web of Science, Google Scholar and Cochrane Library. The following key terms were used: ‘electromagnetic field,’ ‘mobile phones,’ ‘mobile phone base stations,’ ‘watching TV,’ ‘using Internet,’ ‘miscarriage,’ ‘abortions,’ ‘spontaneous abortion,’ ‘early abortion’ and ‘late abortion’. All case–control and cohort studies that investigated the effect of EMF exposure on the risk of miscarriage were included without any restriction of language or time. Statistical analyses were done using Comprehensive Meta-Analysis software (version 2.0). A random-effects model was performed to calculate the overall effect size. A primary search revealed a total of 982 relevant studies; six articles (N = 3,187 participants) met the inclusion criteria for the meta-analysis. The results of the random-effects meta-analysis indicated that EMF exposure had a significant effect on miscarriage: rate ratio (RR) = 1.699; 95% confidence interval (CI): 1.121, 2.363 (P < 0.001); and heterogeneity (I2) = 84.55% (P < 0.001). The findings showed that pregnant woman who were exposed to high levels of EMF had an increased risk of miscarriage.
Comparison of Mast Cell Density and Prognostic Factors in Invasive Breast Carcinoma: A Single-Centre Study in Malaysia
Authors:   Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Awang Ahmad Norashikin ,   Department of Pathology, Hospital Tuanku Ja’afar, Negeri Sembilan, Malaysia,   Department of Pathology, Hospital Sultanah Nur Zahirah, Terengganu, Malaysia, Shau Kong Lai ,   Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Suboh Roslina ,   Department of Pathology, Hospital Tuanku Ja’afar, Negeri Sembilan, Malaysia,   Lablink Medical Laboratory, Kuala Lumpur, Malaysia, Hussin Huzlinda ,   Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Published: November 2023

Background: Mast cells influence tumour growth, neo-angiogenesis and the propensity for metastasis by contributing to innate and adaptive immune responses in the tumour microenvironment. The number of mast cells has increased in various malignant tumours and their abundance has been associated with either a favourable or unfavourable prognosis. This study investigated the significant difference in stromal mast cell density among multiple prognostic factor groups in invasive breast carcinoma. Methods: CD117 (c-KIT) antibodies were used to stain 160 formalin-fixed and paraffinembedded invasive breast carcinoma tissues to demonstrate the presence of mast cells. Then the labelled mast cells were counted in 10 fields at 400× magnification and the mean value was used to represent the mast cell density. Results: The demographic distribution revealed that most patients were 40 years old or older (92.5%) and of Malay ethnicity (66.3%). With regard to prognostic factors, the most prevalent subtype was invasive carcinoma of no special type (80.6%), followed by tumour grade 3 (41.3%), T2 tumour size (63.1%), N0 lymph node stage (51.3%), presence of lymphovascular invasion (59.4%), positive oestrogen (64.4%) and progesterone receptors (53.1%), and negative human epidermal growth factor receptor 2 (HER2) expression (75.0%). However, there was no significant difference in stromal mast cell density among the different demographic and prognostic factor groups in invasive breast carcinoma. Conclusion: The findings from this study suggest that stromal mast cells do not play a significant role in preventing or promoting tumour growth in invasive breast carcinoma.
Ab initio calculations and crystal structure simulations for mixed layer compounds from the tetradymite series
Authors: Yao Jie , Ciobanu Cristiana L. , Cook Nigel J. , Ehrig Kathy , Dima Gabriel I. , Steinle-Neumann Gerd
Published: November 2023

Density functional theory (DFT) is used to obtain structural information of seven members of the tetradymite homologous series: Bi2Te3 (tellurobismuthite), BiTe (tsumoite), Bi4Te3 (pilsenite), Bi5Te3, Bi2Te, Bi7Te3 (hedleyite), and Bi8Te3. We use the formula S(Bi2kTe3)·L[Bi2(k+1)Te3] as a working model (k = 1–4) where S and L are short and long modules in the structures. The relaxed structures show an increase in the a parameter and decrease in the interlayer distance (dsub) from Bi2Te3 (2.029 Å) to Bi8Te3 (1.975 Å). DFT-derived formation energy for each phase indicates that they are all thermodynamically stable. Scanning transmission electron microscopy (STEM) simulations for each of the relaxed structures show an excellent match with atom models. Simulated electron diffractions and reflection modulation along c* are concordant with published data, where they exist, and with the theory underpinning mixed-layer compounds. Two modulation vectors, q = γ·csub* (γ = 1.800–1.640) and qF = γF·dsub* (γF = 0.200–0.091), describe the distribution of reflections and their intensity variation along dsub* = 1/dsub. The γF parameter reinforces the concept of Bi2kTe3 and Bi2(k+1)Te3 blocks in the double module structures, and γ relates to dsub variation. Our model describing the relationship between γ and dsub allows prediction of dsub beyond the compositional range considered in this study, showing that phases with k >5 have values dsub within the analytical range of interlayer distance in bismuth. This, in turn, allows us to constrain the tetradymite homologous series between γ values of 1.800 (Bi2Te3) and 1.588 (Bi14Te3). Phase compositions with higher Bi/Te should be considered as disordered alloys of bismuth. These results have implications for mineral systematics and classification as they underpin predictive models for all intermediate structures in the group and can be equally applied to other mixed-layer series. Our structural models will also assist in understanding variation in the thermoelectric and topological insulating properties of new compounds in the broader tetradymite group and can support experimental work targeting a refined phase diagram for the system Bi-Te.
Different methods of extraction of bioactive compounds and their effect on biological activity: A review
Authors: GHENABZİA Imane , HEMMAMİ Hadia , BEN AMOR Ilham , ZEGHOUD Soumeia , BEN SEGHİR Bachir , HAMMOUDİ Rokaia
Published: November 2023

As of yet, there isn't a single technique that is accepted as the standard for extracting bioactive chemicals from plants. Methods. The effectiveness of both traditional and unconventional extraction methods largely depends on key input variables, knowledge of the composition of plant matter, bioactive chemical chemistry, and scientific knowledge. Results. The necessity for the most suitable and standardized technology to separate active ingredients for plant matter is highlighted by the utilization of bioactive chemicals in several economic sectors, including the pharmaceutical, food, and chemical industries. This review aimed to discuss there are several extraction methods and their basic mechanisms for the extraction of bioactive substances from medicinal plants.
Pripovjedačko sveznanje i problem fikcionalne istinitosti devijantnih evaluacija
Authors: Vujošević Vladimir
Published: November 2023

Problem fikcionalne istinitosti devijantnih evaluacija naziv je paradoksa koji je u posljednjih tridesetak godina postao predmet debate u filozofiji književnosti analitičke tradicije. Filozofi poput Waltona, Tannera, Morana, Gendler i drugih konstruirali su »mini-fikcije« koje navodno pokazuju da autor, bez obzira na svoje skoro pa neograničene ovlasti u pogledu toga što može učiniti istinitim u svijetu priče, ipak ne može uspješno konstruirati fikciju u kojoj bi evaluacija koju smatramo netočnom u aktualnome svijetu bila istinita. Primjerice, netko osmisli fikciju u kojoj se zbiva brutalno ubojstvo iz častohleplja. Takav događaj autor postulira i mi, kao čitatelji, to prosto prihvaćamo kao istinito u svijetu fikcije. No, zamislimo da je dio opisa ubojstva pripovjedačka evaluacija takvoga čina kao moralno ispravne stvari. Evaluaciju koju smatramo »devijantnom« u odnosu na naša aktualna (moralna) vjerovanja ne prihvaćamo kao integralni dio fikcionalnog svijeta, iako autor to traži od nas. Paradoks je u tome što izgleda kako je osnovna konvencija fikcijâ da su svi pripovjedački iskazi u trećem licu koji se ne mogu pripisati likovima fikcije uvijek fikcionalno istiniti. Čini se da je to bitno ograničenje pripovjedačkog autoriteta koje nas navodi preispitati naše uobičajeno razumijevanje fikcija. No, u članku argumentiramo, analizirajući konkretne »minifikcije«, kako (i) nema dovoljno razloga pretpostaviti da devijantnu evaluaciju u fikciji izri- če pripovjedački glas u trećem licu koji se ne može poistovjetiti s nekim fikcionalnim likom; (ii) da devijantne evaluacije uvijek mora izricati osobni pripovjedač; (iii) da takvi osobni pripovjedači nikad nisu sensu stricto »sveznajući« te im ne moramo bespogovorno vjerovati kada, primjerice, zločin evaluiraju kao »ispravnu stvar«. Cijeli paradoks, tvrdimo, tek je pseudoproblem generiran ignoriranjem konkretnih čitalačkih praksi i simplificiranim shva- ćanjem pripovjedačkih konvencija.
Twórczość literacka dzieci i jej edukacyjny wymiar
Authors: Gołuńska Katarzyna
Published: November 2023

Rozwój twórczego myślenia jest istotny na każdej płaszczyźnie - a jak rozwijać twórczość dziecka w zakresie edukacji polonistycznej? Niniejszy artykuł ma na celu przedstawienie, jak zachęcać uczniów klas I-III do własnej twórczości literackiej. Obejmuje także zakres ćwiczeń, podzielonych tematycznie, mających na celu wspomóc kreatywność literacką uczniów, a także, jak nie pominąć celowości tworzenia i realizować zajęcia opierając się o techniki C. Freineta. W pracy podjęta jest również analiza przypadku - dziecka literackiego i jego twórczości od najmłodszych lat.
Nowoczesna komunikacja marketingowa jako sposób na utrzymanie relacji z klientami kawiarni w trakcie pandemii Covid-19
Authors: Ziółkowska Zuzanna
Published: November 2023

Gdy na początku marca 2020 roku pojawił się koronawirus, świat „stanął na głowie", a życie przeszło do formy zdalnej. Obudziliśmy się w świecie zachwianych relacji międzyludzkich, ograniczonych przez zakazy wyjścia i dystans społeczny. Bardzo mocno ucierpiały w tej sytuacji firmy, a zwłaszcza branża gastronomiczna. Okazało się, że świat wirtualny pomógł przetrwać wielu z nich najtrudniejsze chwile, co na przykładzie kawiarni Spoko Cafe z Włocławka zostało przedstawione w niniejszym artykule.
Een vergeten stem. Vrouwelijke slachtoffers van seksueel geweld en het forensisch medisch onderzoek (Antwerpen, 1895-1925).
Authors: De Lannoy Jade , Wils Kaat
Published: November 2023

Aan het begin van de twintigste eeuw hielden rechtszaken rond seksueel geweld een groot risico in voor vrouwelijke slachtoffers. Bij medische onderzoeken en tijdens het proces moest het slachtoffer de eigen morele reputatie verdedigen, wat binnen de dominante culturele denkbeelden over vrouwelijke seksualiteit geen gemakkelijke opdracht was. In dit artikel wordt aan de hand van verschillende Antwerpse assisenzaken onderzocht hoe de juridische behandeling van zedenfeiten getekend werd door deze gegenderde opvattingen. Hierbij worden in het bijzonder de rol van de gerechtsarts en de stem van het vrouwelijke slachtoffer bestudeerd.
Impact of Change Management on Minority Foundation Students’ Ethnic Identity in China
Authors: Huang Yi , Sukumaran Sheiladevi , Ma Fei
Published: November 2023

This study illustrated the practical pedagogy of ethnic identity for minority foundation students. In order to identify sustainable change management of ESD (Education for Sustainable Development) for minority foundation students, the study conducted a qualitative approach to explore the factors that have impacts on the ethnic identity of minority foundation students. By analyzing related literature, the study found that five categories in change management with ESD impact ethnic identity in four dimensions. Thus, a conceptual framework was generated, a strategy for sustainable change management of ESD for those students based on their ethnic identities.
Influence of Parental Expectations on Young Children’s Approaches to Learning
Authors: Bai Jieqiong , Sukumaran Sheiladevi , Han Yueqi , Zhou Jing
Published: November 2023

This study explores the level of young children’s Approaches to Learning (ATL) in Shanxi, China, with a specific on the impact of parental expectations on ATL. 360 parents with preschool-aged children were enlisted for a comprehensive questionnaire survey. Applying descriptive statistics, inferential statistics, correlation, and regression analyses on the data gathered revealed that children's ATL was moderate, with noticeable variations based on gender and age. Importantly, parental expectations were positively correlated with children's ATL and remained a significant predictor even when accounting for age and gender, highlighting the strong relationship between parental expectations and early learning development.
Palm Oil Export and Environmental Pollution in Malaysia: Evidence from ARDL Approach
Authors: Othman Norashida , Alpandi Rabiatul Munirah , Din Norrina , Benalywa Zineb Abdulaker
Published: November 2023

This paper seeks to identify the effect of palm oil export on environmental pollutants. The National Income (GDP) and Foreign Direct Investment (FDI) were also included in the model as control variables. This study employs the auto-regressive distribution lag (ARDL) econometric technique, and the analysis is based on time series data from 1990 to 2020. The bound F-test and Johansen cointegration tests confirmed that palm oil export significantly accelerates environmental pollution. However, the results from the short-run estimate explore that all the variables are insignificant. This study concludes that Malaysia should control international trade activities to deal with pollution problems.
Factors that influence feeding practices among parents in Puncak Alam, Selangor
Authors: Ab Hamid Mohd Ramadan , Majid Norhaini , Wan Ismail Wan Marina , Laili Uliyatul
Published: November 2023

Many factors influence feeding practices, such as socioeconomic status, cultural beliefs, and educational background. This study aimed to identify the factors that influence parents' eating habits in Puncak Alam, Selangor. A comprehensive feeding practices questionnaire (CFPQ) was used for data collection. A total of 201 participants responded to the questionnaire. Working mothers and non-working mothers were found to significantly influence emotion regulation and restriction for weight control feeding practices. By understanding the factors involved, efforts can be made to create a positive and sustainable nutrition environment for children in Puncak Alam, Selangor.
Employee Perception of Information Sharing on Supply Chain Performance
Authors: Ahmad Noraini , Yahaya Syazwani , Mohd Tan Athirah , Shafighi Najla
Published: November 2023

The telecommunication industry holds an immense share in Malaysian economic activities. This study aimed to determine the relationship between information sharing and supply chain performance, as well as whether this relationship is mediated by logistics integration. The study was conducted among 361 respondents from 21 Malaysian telecommunication firms in Malaysia by applying a structural equation modelling with SmartPLS. Findings revealed information sharing associated with supply chain performance. Logistics integration mediated the relationship between information sharing and supply chain performance. The study has implications for practitioners in the decision-making process of supply chain procedures in the telecommunications industry.
Visible Learning: Private Institution Lecturers’ Perspectives on Enhancing the Quality of Teaching Life
Authors: Tong Hoey Chin Christy , Sidhu Gurnam Kaur , Wang Ruoyu
Published: November 2023

Enhancing the quality of teaching promotes a sustainable educational ecosystem, hence recognising the importance of Visible Learning. This study aimed to explore lecturers’ perspectives of Visible Learning and the predictor mindframes of Visible Learning, which significantly contributed to the student’s academic achievement. This study adopted a mixed-methods approach involving 93 lecturers in a private university. The findings revealed that lecturers positively viewed Visible Learning and believed that providing feedback, knowing the impact of their teaching, and engaging students impacted students’ academic achievement. The results suggest that comprehensive training and support must be provided to ensure continuous quality of teaching life.
Development of a Learning Progression Assessment Tool for Electrostatics Utilizing the Rasch Model
Authors: Sun Dehui , Sukumaran Sheiladevi , Gao Song
Published: November 2023

The Learning Progression (LP) model has gained significant attention in science education due to its successful integration of students' cognitive development with scientific concepts. This study aims to address the challenges of delivering the electrostatic field topic in physics education at the tertiary level, where students often find it abstract and challenging to grasp. To create a tailored electrostatic LP model suitable for this educational level, appropriate teaching tools were developed. The Electrostatic Field Test (EFT) was devised and subjected to validation using Rasch models. The validation results affirm the EFT's reliability and validity.
Impact of Child-Friendly Campus Landscaping on Learning and Social Behavior
Authors: Wang Tongyun , Rahman Norhafizah Abdul , Ghani Izham Abdul , Heath Tim
Published: November 2023

This paper mainly explores the research scope of the impact of a child-friendly campus landscape on children's learning and social behavior, adopts a mixed research method combining qualitative and quantitative research, and selects two primary schools with different landscape characteristics in HeZe City, China as research objects and conducts a comparative study on them. The research data obtained by the comparison show that the child-friendly campus environment can stimulate students' interest in learning and promote interpersonal communication among students. However, the child-friendly campus landscape also has certain limitations, which will be further expanded and improved in future studies.
Sustainable Development in Luang Prabang: Analysis of Trends, Challenges, Solutions
Authors: Lizunova Mariia
Published: November 2023

This study reports the current state of sustainability in Luang Prabang, Lao PDR, featuring the industry of heritage tourism, and draws attention to the use of collaborative methods in meeting the needs of local communities, visitors, businesses, and environment preservation. A transition towards sustainability in Luang Prabang is the main object. Alongside the examination of the sustainability level, it proposes an establishment of a preferred and present-day scenario for the local management to refer to. Following, an essential aim lies in providing awareness and understanding of existing problems, trends, and challenges in the tourism industry.
Effect of a Follow-up Program Involving an Early Intervention and Self-help Group on Parenting Stress, Depression, and Parenting Efficacy for Mothers of Premature Infants
Authors: Ji Eun Sun , Choi Jinhee , Shim Kaka
Published: November 2023

Purpose: This study is intended to investigate the impact of an early intervention and follow-up program involving self-help groups on maternal parenting stress, depression, and parenting efficacy in families with premature infants.Methods: The study included 30 mothers in the experimental group and 29 in the control group, all of whom had premature infants in the neonatal intensive care unit. Changes in dependent variables before and after the followup program were analyzed using paired t-tests with mean and standard deviation, and variables that differed in presurvey scores were analyzed using analysis of covariance with covariates.Results: Parenting stress decreased in the experimental group that participated in the follow-up program, while it increased in the control group. Depression decreased by 3.44 points in the intervention group and 1.76 points in the control group. Parenting efficacy increased by 3.03 points in the experimental group and decreased by 1.03 points in the control group after the program.Conclusion: This study highlights the significance of offering family-centered early interventions within existing hospitals or institutions, rather than relying solely on home visits, to promptly address the early developmental issues of premature infants, share information, and provide emotional support through regular self-help meetings.
Peri-transplant Treatment with Ceftaroline in Kidney Transplant Recipients at Risk of Donor-derived MRSA Infections: A Case Series
Authors: Pinchera Biagio , Carrano Rosa , Trucillo Emilia , D'Agostino Alessia , Sardanelli Alessia , Mercinelli Simona , Salemi Fabrizio , Piccione Amerigo , Schettino Elisa , Romano Paolo , Rompianesi Gianluca , Troisi Roberto Ivan , Gentile Ivan
Published: November 2023

The rising prevalence of MDR pathogens has a significant impact on the recipients' outcome, as this increases the risk of graft complications and makes the management of the peri-transplant phase more difficult. Among the different MDR germs, Methicillin-resistant Staphylococcus aureus (MRSA) represents one of the most frequently isolated pathogens. We report for the first time the off-label use of Ceftaroline in six kidney transplant recipients with donor peritransplantation MRSA bacteremia at the Division of Kidney Transplant Unit of Federico II University Hospital of Naples, Italy, between September and December 2022. Each patient was followed up for the next three months after transplantation, monitoring the clinical and laboratory outcome, the risk of infection, and the efficacy and safety profile of the treatment performed. In the subsequent three months of follow-up to the transplant, none of the six patients showed donor-related infections. In particular, none of the six patients showed MRSA bacteremia or other related MRSA infections. In conclusion, our real-life experience shows that Ceftaroline could represent a valid therapeutic option in the management of solid organ transplant patients with a risk of donor-derived MRSA infection. However, despite the few cases considered, this approach deserves further investigation in ad hoc studies or clinical trials due to our positive results.
Biological control of the fungi causing root rot disease of Eggplant plants
Authors: Rahman Abdullah Rami Abdul , Ali Hadi Matloob Ahed Abd
Published: November 2023

The study aimed to identify some causes of eggplant root rot disease after isolation and diagnosis in some areas of Babylon Governorate and to evaluate the efficiency of the biological fungus Trichoderma harzianum and extract of some plants in control the pathogens of eggplant seedling death disease. The results of the field survey conducted in the fields of eggplant plants in the province of Babylon showed the presence of root rot in the eggplant in all areas covered by the field survey. Several types of fungi were isolated and identified from the roots of eggplant plants infected with root rot disease. The most frequent pathogenic fungi were Fusarium solani, Rhizoctonia solani, and Macrophomina phaseolina. The results showed that all tested fungi isolates were pathogenic and caused a significant reduction in the percentage of germination of cabbage and eggplant seeds. The results of the pot experiment showed that all the treatments that included the biological factor and aqueous Acacia extract had a significant effect in reducing the growth of pathogenic fungi, especially when the treatments were combined, as measured by the percentage of infection and the severity of infection in the treatment of pathogenic fungi F. solani, R. solani and M. phaseolina, Alone, the infection rate was 100.00%, and the severity of the infection was 76.67, 70.00 and 66.67%, respectively. The treatment of integration between the biological factor T. harzianum and the aqueous extract of Acacia achieved high superiority in reducing the infection rate, as it ranged between 11.11-24.33% and the severity of infection 4.44-15.00%. Keywords: Plant extracts, Eggplant, fungi, root rot, Trichoderma harzianum.
Relationship between IL-6 gene polymorphism rs1800796 and IL-6 serum
level with thyroid Hormones in a sample of Iraqi celiac disease patients.
Authors: Ali Abd AL-Hussein Shams , Ahmed Jasim Hamssa
Published: November 2023

Celiac disease (CD) is an autoimmune human leukocyte antigen HLA–linked
enteropathy that develops upon ingesting a gluten-containing diet, with diarrhea,
malabsorption, and weight loss as a major presentation. The disease is closely
linked to a number of extra-intestinal disorders, especially endocrine diseases.
This study aimed to find the Relationship between IL-6 gene polymorphism
rs1800796 and IL-6 serum level with thyroid Hormones in a sample of Iraqi
celiac disease patients. The study includes one hundred subjects of Iraqi people in
Baghdad (20-60 years) who were divided into two groups; the first group
included patients, and the second group control; DNA was extracted, then the
Genotyping polymorphism (rs1800796) of the IL-6 gene was done by RT-PCR.
The CC genotype showed a higher frequency in the control, while the GG
genotype showed a higher frequency in the patients.
Keywords: celiac disease (CD), genetic polymorphism IL-6gene, thyroid
stimulation hormone.
Study of the effect of germination on the chemical and nutritional properties
of maize seeds
Authors: Ahmed Sbhie Hmsa , Hafidh Mahommed Baidiaa
Published: November 2023

The research aimed to study the effect of the germination process on the chemical
composition and content of phenolic compounds, phytic acid, mineral elements
and amino acids of locally grown maize. The results of the chemical composition
of the non-germinated maize showed that the content of protein, fat, ash, moisture,
fiber, and carbohydrates were (7.75 - 10.271 - 1.46 - 6.79 -3.173 -70.886) respectively, while the results of germinated maize were from protein, fat, ash, fiber, carbohydrates (9.13- 9.167 -1.27- 5.93- 4.822- 69.861) respectively. As for the number of phenolic compounds, it increased after germination, as it reached germinated
yellow maize compared to non-germinated maize (159 mg/gm-145 mg/gm) respectively, in addition to germination, it reduced the amount of phytic acid in germinated maize compared to non- germinated maize, which amounted to (2.8
mg/100gm). -48.9 mg/100 g) respectively. The percentage of mineral elements,
iron, phosphorous, magnesium, potassium, zinc, and calcium for germinated maize
reached (0.2883-3.87 -0.139-0.078 - 7.76-23.4), respectively. As for non-germinated maize, the percentage of iron, phosphorous, magnesium, potassium, zinc,
and calcium (0.2811-3.43 -0.142-0.086-17.5-21.4) respectively. The effect of germination on the proportion of amino acids: the results showed that germination led
to an improvement in the proportion of some essential and non-essential amino
acids.
Keywords: yellow corn, germination, amino acids, phytic acid
Nanohydroxyapatite in enamel remineralization and tooth hypersensitivity
Authors: Hussein Abd Marwa , H. Jehad Rasha
Published: November 2023

This study evaluates the advantages of employing nano-hydroxyapatite in dentistry, particularly for preventive treatment applications. Only electronically published papers were searched within this review. Sources: "PubMed" website was the only source used to search for data. 92 most relevant papers to the topic were selected, especially the original articles and review papers, from 1990 till the 1st of April 2022. The morphology of nano-hydroxyapatite, as well as the structure of its crystals, are close to that of dental enamel. As a result, hydroxyapatite can biomimetically replace the natural enamel mineral element. Keywords: remineralization of enamel, nanotechnology, nanohydroxyapatite, hypersensitivity.
Effect of adding a combination of herbal powders (turmeric, cumin, anise,
Cinnamon and coriander) in broiler diets on the percentage of dressing,
qualitative traits of the carcass, physiological traits and some indicators of
oxidation of meat
Authors: saeed Al obaidi Mustafa sami , Saleh Al-mashhadani Hisham Ahmed
Published: November 2023

The experiment was conducted in the poultry field of the Department of Animal
Production - College of Agricultural Engineering Sciences - University of Baghdad
/ Abu Ghraib from 20/9/20/2021 to 10/31/2021 (42 days). To study the effect of
adding a blend of herbal powders (Turmeric powder, anise, coriander, cumin, Cinnamomum) to broiler diets on some physiological traits and some indicators of
oxidation in meat. In the field experiment, 240 broiler chicks, 308 Ross, obtained
from Al-Shukr Broiler Production Company, located in Baghdad / Abu Ghraib
province, with an average initial weight of 40.28 g, were used. Each treatment included four replicates of 10 chicks/duplicate, and the experimental treatments were
as follows: T1 control (free of adding herbs), and T2 control treatment containing
antibiotic (oxytetracycline 0.05%) and T5, T4, T3 and T a mixture of herbs in proportions (0.25, 0.50, 0.75, 1%)As this mixture includes five types of aromatic
plants (Turmeric powder, anise, coriander, cumin, Cinnamomum), The results
showed that there were no significant differences in the percentage of dressing, the
treatment T4 (0.50%) achieved the highest weight of the chest and neck piece. In
contrast, T5 and T6 achieved a significant decrease in the weight of the neck. There
were no significant differences in the relative weight of the edible internal viscera,
abdominal fat, and Vibricia gland; as for the physiological traits, the two treatments, T5 and T6, achieved a significant decrease in the urea concentration, and
there was no significant difference between the treatments in creatine. There was
a significant decrease in cholesterol concentration for all additional treatments. In
contrast, for oxidation indicators, the T5 treatment achieved a decrease in the value
of peroxide, with a significant increase in the value of glutathione before storage
and 30 days after storage.
Keywords: herbal powders, turmeric, cumin, anise, Cinnamon, coriander, broiler
diets, oxidation of meat
Study of the inhibitory effect of aqueous extract of thyme leaf powder on alpha-amylase enzyme produced by insect larvae (Trogoderma granarium)
Authors: Raad Shaker Sarah , Mustafa Hakeem Ibtehaj , Moamin Lilo Hasan
Published: November 2023

The study included evaluating the effectiveness of aqueous extract of Thyme leaf
powder on the inhibition of the alpha-amylase enzyme produced by insect larvae
(Trogoderma granarium), as well as studying the most important active compounds
to know their biological effect on the enzyme by using HPLC technology. Optimum conditions of temperature and pH were determined to measure the inhibitor
activity and stability toward the enzyme. The results of HPLC cleared that the
thyme aqueous extract had a high level of tannin, 9 micrograms/ml. The chemical
tests for this study indicated that thyme leaves contain saponins, flavonoids, glycosides, resins and alkaloids. The results showed that the aqueous lyophilization
process gave the best extraction rate of 68% and also preserved the active compounds without heat. It was noted from the study results that the best inhibition of
the enzyme was when using a concentration of 10%, which means that the higher
the concentration of the inhibitor is, the higher its effectiveness. By studying the
various factors, we find that the best temperature for inhibition is 30 °C. As for PH,
it was at pH = 7. It has been concluded in this study that the possibility of using
the extract of thyme to inhibit the alpha-amylase enzyme is produced by Insect
larvae (Trogoderma granarium) as a paradigm.
Keywords: a-amylase, Trogoderma granarium, thyme, lyophilization, HPLC
Protective Effect Of The Antioxidant Butylated Hydroxytoluene (Bht) On
Some Physiological And Biochemical Variables Of Male Rats Exposed To
Stress By Starvation.
Authors: Yousif Al-tikrity Wedyan , Mohamed Al-Mashhadani Thaer
Published: November 2023

This study investigated the effect of Butylated Hydroxytoluene (BHT) on some
physiological and biochemical parameters of rats subjected to stress by starvation,
and 56 mature males were divided into eight groups.(Control, Olive Oil, Starvation, BHT Concentration (100 mg/kg), BHT Concentration (50 mg/kg), Starvation
+ BHT concentration (100 mg/kg), starvation + BHT concentration (50 mg/kg),
starvation + olive oil. The results showed that the olive oil group and BHT groups
at a concentration (50, 100 mg/kg) There was no significant difference in most of
the treatments within the studied variables. In contrast, the starvation group showed
a significant decrease in the concentration of (Total protein, Albumin, Lipase Enzyme, Lactate Dehydrogenase Enzyme (LDH), and Total Antioxidant Capacity
(TAC). The control group, while the starvation + BHT group, did not show a concentration (100,50 mg/kg) Significant difference compared with the control group
in all the variables as mentioned earlier, which shows clearly the protective effect
of BHT against the negative effect of starvation by maintaining its concentrations
within its normal level.
Keywords: BHT; Starvation; Total Protein; Albumin; Lipase Enzyme; LDH;
TAC.
Relationship of the CYP17 gene (T2231A) to milk production and
its components in goats
Authors: Muhammad Abdullah Walaa , Ismail Ibrahim Wafaa , Najm Abdullah Ali
Published: November 2023

The experiment was conducted at the Ruminant Research Station of the General
Authority for Agricultural Research / Ministry of Agriculture on a sample of 53
goats of two breeds (26 Shami goats and 27 local goats), as well as the Scientific
Progress Laboratory specialized in biotechnology and genetic material analysis. In
order to determine the genotypes and allelic repeats of the CYP17 gene in goats to
determine its relationship to milk production and its components, after the completion of the PCR polymerase chain reaction, the results were sent to the Humanizing
Genomics Macrogen Company in South Korea to detect the genotypes of the studied area using the sequencing technology, Two genotypes TT and TA were obtained at the site (T2231A), and the percentage of TT genotype was 26.92% for
Shami goats. The percentage of TA genotype was 73.08, and the relationship between them was significant (P≥0.05). The allelic frequency of the T allele was And
A 0.63 and 0.37, respectively, where the results showed a significant relationship
(P≥0.05) between the genotypes and the amount of total milk production and the
percentage of solids that are not fatty. The animals carrying the TT genotype recorded the highest amount of production than those carrying the TA genotype,
571.08 ± 48.69 and 432.24 ± 50.56, respectively. Also, the animals carrying the
TT genotype outperformed the animals carrying the TA genotype in the percentage
of solid non-fat components, which scored 12.79 ± 1.66, and they scored 9.89 ±
1.63. The percentage of TT genotype for domestic goats was 40.74%, and the percentage of genotype TA was 59.26. the relationship between them was significant
(P≥0.05), and the allelic frequency of the T and A alleles was 0.70 and 0.30, respectively. The results also showed a significant relationship (P≥0.05) between the
genotypes and the amount of total milk production of the local goats, where the
animals carrying the TT genotype recorded the highest amount of production than
the animals carrying the TA genotype, and it scored 548.15 ± 72.06 and 350.10 ±
47.94, respectively. Thus, the CYP17 gene can be used in genetic improvement
programs.
Keywords: Goats; CYP17 Gene; Genotype; Milk Production.
Efficiency of the fungal filtrate Beauveria bassiana and the alcoholic extract
of Artemisia herba-alba against the greater wax worm Galleria mellonella
L. (Lepidoptera: Pyralidae) in Babylon Province
Authors: Hamad Hamza Al Sultani Baraa Salam , Ghanem Hamza Abbas
Published: November 2023

A laboratory study was conducted to determine the effect of the filtrate of the fungus Beauveria bassiana and the alcoholic extract of the wormwood plant Artemisia
herba-alba on the destruction of the larval stages of the waxworm major; the results
of the study showed that the filter of the fungus B. bassiana affected the destruction
of the larval stages of the waxworm. The highest mortality rate was 76.7% for the
second larval stage after 24 hours of treatment with a 30% concentration, while it
reached 86.7% after 168 hours of treatment with the same concentration. The lowest mortality rate was 13.3% for the last larval stage after 24 hours of treatment,
with a concentration of 10%. In comparison, the death rate was 30.0% after 168
hours of treatment, with a concentration of 10%. The results also showed that the
alcoholic extract of the wormwood plant affected the destruction of the larval
stages of the insect.
Keywords: Fungal; Alcoholic Extract; Wormwood.
Human Bocavirus Diagnosis by Molecular Method from Respiratory Infection Patients in Mosul City
Authors: A. AlTaie Anmar , Abdul-Ghani Muhammad Muhammad , M. Salih Mohammad , Raad Abdulghany Noor , Mutasher Auf Iman
Published: November 2023

The Bocavirus, which causes respiratory illness in the lower respiratory tract in
newborns, children, and healthy adults, was investigated in this study. Methodology and results: The samples were taken as Nasopharyngeal / Throat swabs kept
in sterile VTM ( Viral Transport Media ), Which was collected from Mosul Hospitals within six months of the study. The Tested patients' ages ranged from under
20 to above 40 ( between 11 57 ) for both sex males and females. The dominion
age group was above 30, and the DNA of this virus was extracted by the real-time
PCR method ). Conclusion, significance, and impact of study: the molecular test
indicates positive in twenty-four samples from all 70. This demonstrates the presence of Bocavirus in ( 20%) males and ( 14.28%) female understudies.
Keywords: Respiratory Tract infections, Bocavirus, Real-time PCR, Virus
Transport Media, Viral Transport Media.
Minimizing the side effects of Doxorubicin Induced Hepatotoxicity by using
alcoholic extract of Date Palm in adult rats
Authors: Sulaiman Saleh Najwa Imad , Agmee Wadee Siham , R. Sarhat Entedhar
Published: November 2023

Doxorubicin (DOX) is a highly effective drug for chemotherapy. However, hepatotoxicity reduces its clinical utility in humans. Thus, this study was designed to
examine Date Palm extract on serum anti-inflammatory markers (interleukin(IL)
IL-1B, IL-6 and IL-10). Forty adult rats were divided into 4 groups (G1 control,
G2 receiving 2mg\kg of DPE orally, G3 treated with 2mg\kg of DOX IP, and G4
received 2mg\kg of DOX via IP and 2mg\kg of DPE by oral gavage daily for 30
days). At the end of the study, animals were sacrificed, and livers were analyzed
histologically. The Dox group showed significantly higher levels of serum IL-1B,
IL-6, and IL-10 than the control group, with inflammation and necrosis in hepatic
histopathology. In the DPE+ DOX group, it was detected that DOX treatment
caused a significant decrease in serum IL-1B, IL-6, and IL-10 levels. Collectively,
pre-coadministration of DPE partially mitigated DOX-induced hepatic injuries via
its antioxidant, anti-inflammatory, anti-fibrotic, and antiapoptotic protein.