bluuebunny/crossref_metadata_2025 huggingface dataset:
A NOVEL VALIDATED STABILITY INDICATIVE UPLC METHOD FOR RELUGOLIX FOR THE DETERMINATION OF PROCESS-RELATED AND DEGRADATION IMPURITIES
Authors: Papadasu Narayanareddy , Reddy K. Ramakrishna
Published: May 2024

A Novel Stability-indicating ultra-performance liquid chromatographic (UPLC) method has been developed for the quantitative determination of Relugolix, API along with its four process-related impurities (Impurity-1, Impurity-2, Impurity-3, Impurity-4) and its degradation impurities. The method was applicable for the quantification of related substances and assay in Relugolix. Efficient chromatographic separation was achieved by using BEH RP-18 column, 100 x 2.1 mm, 1.7 µm, and gradient mobile phase with a run time of 10 minutes. The mobile phase contains a gradient of solvent A (1 % orthophosphoric acid in water) and solvent B (Acetonitrile). The flow rate of the mobile phase was 0.4 mL/min, the column oven temperature was maintained at 30°C, and the eluted peak was detected at 215nm. Stress degradation conditions were set for Relugolix by exposing it to water, acid, base, oxidation, humidity, thermal, and photolysis. The stress samples were assayed against a qualified reference standard and the mass balance was approximately 98.0%. The developed UPLC method was validated according to the current ICH guidelines. The resolution between Relugolix and its impurities was found to be more than 4.0. Regression analysis shows that the correlation coefficient (r-value) is greater than 0.999 for Relugolix and its impurities. This method is capable of detecting Relugolix and its impurities at a level of 0.003 % for LOD and 0.01 % for LOQ with respect to the test concentration of 1.0 mg/mL. The objective of this work was to develop a cheap and efficient UPLC method to demonstrate its stability-indicating capabilities by forced degradation.
NATURAL CLAY MINERALS FOR REMOVAL OF CATIONIC DYE: KINETIC, ADSORPTION, AND THERMODYNAMIC STUDY
Authors: Yakkerimath Shilpa , Kulkarni Raviraj M. , Divekar Sanjaykumar V. , Chate Vaibhav R. , Kunkangar Purandara Bekal
Published: May 2024

In recent years managing ecological changes and comprehending diverse anthropogenic contributions towards pollution is now of great concern due to industrialization. Therefore, creating an environmentally friendly solution for dealing with harmful substances like Methylene Blue in water has become a critical issue. This experimental investigation aims to design and assess the unmodified clay mineral of the Panchaganga River flood zone for the removal of MB by batch tests. The removal of MB was examined by optimizing all the variables, further XRD, SEM, EDX, BET, and FTIR, were all used to meticulously examine the NC before and after adsorption. Methylene Blue content was determined by UV-visible spectrophotometrically, and the mechanism of NC’s adsorption to MB in water was examined by modeling isotherm and kinetics studies. At pH 7.00 to 8.00, the NC showed a high extraction of MB due to negatively charged clay surface (Si-O- ), (Al-O- ). The adsorption capacity qm obtained was 88.8 mg/g (Langmuir). The kinetics study showed that the adsorption mechanism follows pseudo-2nd-order indicating chemisorption as a rate-determining step, moreover, adsorption also occurs via the intra-particle-diffusion process due to small pores on NC. The study demonstrates that the NC exhibits significant efficacy in efficiently removing the cationic dye (MB) pollutant from waste-water systems.
SUSTAINABLE CONSTRUCTION OF PYRANOPYRAZOLES UTILIZING HClO4-SiO2 AS AN EFFICIENT SOLID CATALYST AND DOCKING STUDIES
Authors: Pogaku Bhadraiah , Srinu Janapati , Pagadala Ramakanth , Perugu Shyam , Mone Radhika , Reddy Kamireddy Kamalaker
Published: May 2024

This article introduces a highly proficient and environmentally friendly process for producing pyranopyrazole-5- carbonitriles with outstanding yields. This involves a multicomponent synthesis using commonly available aldehydes, malononitrile, ethyl acetoacetate, and phenylhydrazine, conducted in ethanol with perchloric acid supported on silica (HClO4-SiO2) as a solid catalyst. Utilizing HClO4-SiO2 as a reusable catalyst underscores the sustainability of this approach, offering a valuable green chemical strategy for pyranopyrazole synthesis. Characterization of the synthesized compounds was achieved using FTIR, 1H NMR, 13C NMR, and Mass spectrometry. Additionally, molecular docking studies revealed significant binding energies of the compounds to receptor-active sites, further validating their potential pharmacological relevance.
ФУТБОЛЬНИЙ ФІТНЕС У ФОРМУВАННІ ГОТОВНОСТІ ТРЕНЕРІВ З ФУТБОЛУ ДО ПЕДАГОГІЧНОГО ДИЗАЙНУ
Authors: ТИМОШЕНКО Олексій
Published: May 2024

Стаття розглядає важливість єдності фізичного, інтелектуального і духовного розвитку тренерів у контексті їхньої готовності до застосування педагогічного дизайну в професійній діяльності. Автор наголошує на значенні конструктивного проєктування середовища футбольної культури, що включає соціокультурні, історичні, емоційні та поведінкові аспекти, пов'язані із футболом. Особлива увага приділяється гармонійному розвитку сутнісних сил гравців за допомогою сучасного футбольного фітнесу. Автор показує, що футбольний фітнес сприяє підтримці оптимального рівня фізичної форми, підвищенню енергопотенціалу та розвитку різноманітних фізичних якостей, що є важливими для успішної проєктно-творчої діяльності тренера. Зокрема, висвітлено роль фітнес-культури, зорієнтованої на індивідуальний вибір особистісно-ціннісних напрямів для покращення фізичного стану гравців. Підкреслюється значення інноваційних технологічних пристроїв для саморегулювання процесу оздоровлення. У статті також обговорюється важливість особистісно зорієнтованої фітнес-культури для пробудження конструктивної саморефлексії у гравців і формування готовності до педагогічного дизайну у тренерів. Автор вказує на необхідність врахування біологічних конституцій гравців і наголошують на тому, що спортивна діяльність повинна відповідати їхнім особливостям. Стаття висвітлює важливість фітнесу та особистісно-орієнтованого підходу в підготовці тренерів з футболу.
Футбольний фітнес є важливим фактором, який впливає на формування готовності тренерів до застосування педагогічного дизайну. Використання інтерактивних методів навчання та знання про індивідуальні особливості спортсменів дозволяють тренерам проектувати ефективний навчальний процес, що сприяє розвитку спортивної творчості та досягненню високих результатів.
Запропоновані інтерактивні методи та інноваційні напрями фітнес-культури можуть бути впроваджені у практику роботи тренерів з футболу для підвищення ефективності навчального процесу.
Effect of Sociodemographic Factors on the Risk of Postpartum Depression during the Covid-19: Evidence from Tarakan
Authors: Febrianti Selvia , Ariyanti Ririn , Jalilah Nurul Hidayatun
Published: May 2024

Social and environmental factors can have an impact on a mother's mental health, especially during a pandemic. Financial stress and the social environment can exacerbate postpartum depression. Postpartum depression is one of the mental health consequences. Postpartum depression is similar to other types of depression, but it occurs as a result of physical and social changes caused by the process of giving birth and raising a child. The objective of this study was to identify the sociodemographic factors that influence the risk of postpartum depression in Tarakan during the Covid-19 pandemic. It was a cross-sectional study conducted in Tarakan's North Tarakan District from August to October 2021. The study included 150 postpartum mothers. In this study, simple random sampling was used. The dependent variable of this study was postpartum depression and independent variables were age, education, income, parity, occupation, and support. Data collection employed questionnaires and logistic regression data analysis with the Stata 13 program. The risk of postpartum depression increased with multiparity (95%CI: 0.11-1.78); p = 0.026), and less income (< minimum wage) (95%CI: 0.01-1.48); p=0.045). The risk of postpartum depression decreased with age (<35 years old) (95%CI: (-2.00) - (-0.25)); p= 0.011), occupation (95%CI: (-1.60) – (-0.07)); p= 0.032), support (95%CI: (-1.76) – (-0.10)); p= 0.028), higher education (95%CI: (-1.22) – 0.24); p= 0.190). Postpartum depression risk increases with multiparity and lower income. With normal age, occupation, support, and education, the risk of postpartum depression decreased.
The Effect of Knowledge of Mothers Assisted by Cadres during Pregnancy on the Incidence of Low Birth Weight
Authors: Rasyid Puspita Sukmawaty , Claudia Juli Gladis , Agustini Rahma Dewi , Nurhidayah Nurhidayah , Yanti Febri Dwi , Luawo Herman Priyono
Published: May 2024

Every pregnancy carries risks to the quality of birth outcomes, such as low birth weight (LBW). Interventions such as increased maternal knowledge, supervision, and intensive assistance are required, which can be performed by health cadres. The study aimed to examine the impact of knowledge on the incidence of LBW in pregnant women accompanied/assisted by cadres during pregnancy. This method combines descriptive research with a quasi-experiment. The study included 30 pregnant women who fulfilled the following criteria: single pregnancy, 30 weeks gestation, not a high-risk pregnancy, and no comorbidities. The study lasted three months, and the independent variable was the knowledge of pregnant women assisted by cadres, while the dependent variable was the incidence of LBW. Pregnant women's questionnaires and observation sheets were employed as instruments. T-Test and Yates' Correction were utilized during data analysis. The findings revealed a p-value of 0.031 increase in knowledge of pregnant women before and after being assisted by cadres during pregnancy, and the incidence of LBW was 3 cases (10%). With a p-value of 0.041, the results of Yates' Correction statistical test revealed that knowledge of pregnant women assisted by cadres is one of the determinants of the occurrence of LBW. It is critical to increase cadre involvement and role in assisting pregnant women.
The Effect of Sombere Education on Stress Levels in Primigravida Pregnant Women
Authors: Sudirman Jumrah , Syafar Muhammad , Jusuf Elizabet Catherine , K Rahayu Eryanti
Published: May 2024

Mental health problems during pregnancy are major public health issues that require immediate attention. Anxiety and stress can have an impact on pregnancy and childbirth. This study examines the impact of Sombere education on the stress levels of pregnant women. A quasi-experimental design with a pre-test and post-test design and a control group was employed in this study. This study's sample consisted of 80 primigravida pregnant women who met the sample criteria. Purposive sampling was utilized in this study. The chi-square test and the Wilcoxon rank test were implemented to analyze the data. The findings of this study revealed that there was a difference in stress in the intervention group after treatment (p=0.000<0.005), as well as a difference in stress in the control group during the post-test (p=0.001<0.005). Sombere education has an effect on stress levels in primigravida pregnant women (p=0.016<0.005). The requirement Midwives provide education on maternal mental health, particularly the stress of pregnancy. In addition, midwives must conduct stress assessments or collaborate with psychologists to ensure pregnant women's mental health.
Implementation of Telemedicine through “Apoteker Keluarga Online” Application as an Effort for Rational Headache Self-Medication
Authors: Octavia Devi Ristian , Utami Primanitha Ria , Susanti Irma
Published: May 2024

People who seek self-medication for acute headaches in pharmacies are not properly diagnosed and treated. Irrational drug use has a high potential for causing medication errors. The AKO application is one of the digital counseling service apps managed by a pharmacist who has a strategic role in educating patients on self-medication behavior in telemedicine services. The objective of this study is to identify the benefits of AKO use in increasing rational self-medication behavior in headache complaints. It is a descriptive analysis study with a case-control design. The population is the Lamongan community who have had headache self-medication. Samples were taken by purposive sampling technique. A total of 130 participants were divided into two groups: the intervention group and the control group. A headache self-medication questionnaire was employed as the instrument. The collected data was then analyzed using the Mann Whitney test to determine the value of the AKO application in increasing knowledge of the rationality of self-medication in headache complaints. The data from the measurement of the level of knowledge of the rationality of headache self-medication revealed that the majority of the intervention group (92.3%) had good knowledge and none had poor knowledge. While there are still respondents with less knowledge (15.3%) in the control group. The statistical test results for the benefits of AKO application assistance on the level of knowledge of the rationality of headache self-medication revealed a p value = 0.000, indicating a significant difference between the intervention and treatment groups. The use of telemedicine via the AKO application can increase public awareness of the rational use of headache medications. Digital health services can be used as a medium for counseling and remote patient health monitoring.
The Impact of Visfatin Level Against Blood Pressure Among Pregnant Women
Authors: Rinawati Luh Putu , Yanty Jannah Sofy , Rakhmawati Aprilia , Bekti Heri Setiyo
Published: May 2024

Visfatin, a protein with a molecular weight of 52 kDa, has been demonstrated to increase in the bloodstream. Visfatin has been shown in several studies to be a potential marker of preeclampsia. The objective of this study was to describe visfatin levels in pregnant women in Gianyar, Bali. An observational design was employed in this study to describe visfatin levels in 41 pregnant women in Ubud, Gianyar regency, Bali. Visfatin levels were determined by examining EDTA blood samples using the Elisa method and reading them at 450 nm on a microplate reader. The average value of visfatin levels was 6.49 ng/ml, according to the results. The average visfatin level based on hypertension blood pressure respondents was 3.74 ng/ml. This result was lower than that of normal blood pressure respondents.  This study's decrease in visfatin levels may have a smaller effect on physiological insulin resistance. The average visfatin level in second trimester respondents was 7.9 ng/ml higher than 5.7 ng/ml in third trimester respondents. The increase in visfatin levels suggests that visfatin may play a role in the pathogenesis of preeclampsia. Visfatin has the potential to be used as a biomarker to detect preeclampsia earlier, allowing pregnant women with preeclampsia to receive appropriate treatment.
Compliance Level of PAUD Students in Brushing with the Interactive Calendar Guide
Authors: Laela Dewi Sodja , Aliyah Raisya , Restuning Sekar , Fatikhah Nurul
Published: May 2024

Brushing teeth properly and correctly must be instilled in children from an early age so that they become accustomed to living a clean and healthy lifestyle. Dental health education can help people develop good brushing habits. Brushing your teeth in the morning and evening for 21 days is an interactive calendar designed to control the implementation of brushing your teeth in the morning and evening. The objective of this study was to assess PAUD (Pre-School) students' compliance with morning and night toothbrushing using an interactive calendar guide to brushing their teeth in the morning and evening for 21 days. The research method used is pre-experimental. Simple random sampling method was also administered. The research intervention was conducted on 32 PAUD Bahagia Sukapura and Al Abror students. A questionnaire and an interactive calendar sheet were used as research instruments. The results showed that before the intervention, the average score of PAUD children's compliance with brushing their teeth in the morning and evening was 46.9063, but after the intervention, it increased to 79.0313. Before the intervention, the level of adherence to brushing teeth in the morning and evening was in the less compliant category (40.6%), but after the intervention with an interactive calendar, it increased to (96.9%). The Wilcoxon Sign Rank Test analysis revealed a difference in pre- and post-intervention scores on children's compliance data in brushing their teeth using the morning and evening brushing calendar for 21 days, with a p-value (0.000) <0.05. Brushing their teeth twice a day in the morning and evening for 21 days is effective in increasing PAUD children's adherence to brushing their teeth twice a day in the morning and evening.
The Density of Aedes aegypti Larvae Density and the Incidence of Dengue Hemorrhagic Fever in the Pesingahan Environment, Pagesangan Barat Village, Mataram
Authors: Urip Urip , Rizki Kurnia , Tatontos Erlin Yustin , Gunarti Gunarti , Kholik Kholik
Published: May 2024

Dengue hemorrhagic fever remains a public health concern in West Nusa Tenggara Province, with the majority of cases occurring in Mataram City and the Pesinggahan Environment of West Pagesangan Village. The density of Aedes aegypti larvae as disease vectors has a strong influence on the high incidence of cases and the spread of dengue hemorrhagic fever. The objective of this study was to identify if there was a relation between the density of Aedes aegypti larvae and the rate of dengue hemorrhagic fever in the Pesinggahan Environment of Pagesangan Barat Village. This study is an analytic observational study with a cross-sectional design. This study's sample size was 56 houses. The data collected included information on the density of Aedes aegypti larvae and the incidence rate of dengue hemorrhagic fever in the Pesinggahan Environment of Pagesangan Barat Village over the previous year. Descriptive analysis was used to examine data on the density of Aedes aegypti larvae and the incidence rate of dengue hemorrhagic fever in the Pesinggahan environment. The findings revealed that the density of Aedes aegypti larvae was high (Density Figure (DF) = 6), as was the incidence rate of dengue hemorrhagic fever (0.39%). The statistical analysis between the density of A. aegypti larvae and the incidence rate of dengue hemorrhagic fever in the Pesinggahan Environment with the chi square test demonstrated indicate that p-value = 0.000 < alpha = 0.05. Based on the results of the study, there was a relationship between the density of A. aegypti larvae and the incidence rate of dengue hemorrhagic fever in Pesinggahan, Pagesangan Barat Village. Further research is required regarding the detection of the dengue virus transmitted by A. aegypti mosquitoes to their offspring (transovarial).
Does Effleurage Massage Reduce Dysmenorrhoea Pain in Adolescents?
Authors: Sumiaty Sumiaty , Nurfatimah Nurfatimah , Sartika Yuni , Ramadhan Kadar
Published: May 2024

Dysmenorrhea, commonly known as menstrual pain or cramps, affects some women and hampers their ability to carry out daily activities. In Indonesia, the incidence of dysmenorrhea among women is reported to be 64.25%, with a significant proportion lacking knowledge regarding its management. Non-pharmacological methods, such as effleurage massage, have been suggested as a viable approach to alleviate dysmenorrhea pain. This study aimed to investigate the impact of effleurage massage on the pain scale associated with dysmenorrhea in adolescents. A quasi-experimental approach utilizing a pre- and post-test for a two-group design was employed. The study population consisted of young women experiencing dysmenorrhea, with a total sample size of 44 respondents divided into intervention and control groups. The research findings revealed a decrease in the mean pain score in the intervention group from 5.1±2.4 to 2.5±1.8 with a p-value of <0.001. Thus, it can be concluded that effleurage massage effectively reduces the intensity of dysmenorrhea pain in adolescents. As a recommendation, adolescents are advised to consider non-pharmacological therapies like effleurage massage as an alternative to pharmacological drugs, and to learn the technique to perform effleurage massage independently at home.
Ergonomic Risk Analysis on Traditional Weaving Workers on Semau Island Kupang Regency
Authors: Ruliati Luh Putu , Setyobudi Agus , Talahatu Anna Henny , Takaeb Afrona Elisabeth Lelan
Published: May 2024

Musculoskeletal disorder has caused casualty on traditional weaving workers. With manual equipment that uses no electricity, the workers do not apply anthropometry into their daily labor; resulting in working with bent position. Such condition forces the workers to be in a non-ergonomic work position. The research objective was to determine the relationship between work fatigue, workload, and work attitude with musculoskeletal disorders in traditional weaving workers. This research is an analytic descriptive research with a cross sectional study design. The sample in this study was 38 traditional weavers. The results showed that there was a relationship between work fatigue, workload, and work attitude with musculoskeletal disorders in traditional weaving workers on Semau Island, Kupang Regency with p-value <0.05. Workers can be given counseling and pamphlets regarding ergonomic and comfortable work, so as to avoid occupational safety and health problems.
Philosophy of Science on The Development of Palliative Nursing Practice in The Implementation of Long-Term Care for The Elderly: A Literature Review
Authors: Agustini Ni Luh Putu Inca Buntari , Satriani Ni Luh Adi , Dewi Ni Putu Ayu Ratna , Yulistina Putu Desi , Dewi Putu Sundari , Putra Putu Agus Sujana , Wijayanatha I Putu Arya , Yudha Gede Khrisna Eka
Published: May 2024

As people gets older can increase health problems due to degenerative processes, thus requiring long-term care. Nurses as providers of palliative nursing care are based on nursing philosophy as a guide for acting and behaving in providing nursing care. Provide scientific information to nurses related to the role of philosophy of science in the development of palliative nursing practice that supports the implementation of long-term care in elderly. A literature review study, using various databases from Pubmed, Google Scholar, Science Direct and Research Gate. The inclusion criteria for searching for literature sources is the year of publication of the articles used starting from 2017 to 2022, in English, Indonesian and full articles. The search keywords are, nursing philosophy, nursing theory, palliative nursing, palliative care. Article selection was carried out using PRISMA and critical appraisal with a final total of 20 articles. The provision of palliative care to patients is carried out through a philosophical approach that emphasizes optimal quality of life and function, mitigates symptoms that cause sadness and promotes the values of care that focuses on comfort so as to reduce suffering and improve the quality of life of patients and families. Palliative nursing includes an understanding of the disease, pain management, and general symptoms, and follow-up care planning. Nurses are expected to make the philosophy of nursing as a basic of human as a holistic being in providing palliative nursing care.
Prenatal Covid-19 on Toddler Development
Authors: Pasongli Seri , Budu Budu , Ahmad Mardiana , Prihantono Prihantono , Hidayanti Healthy , Arsyad M. Aryadi
Published: May 2024

Along with the spread of the COVID-19 pandemic, there has been an increase in reports of confirmed cases of pregnant women with COVID-19. Exposure to the virus in pregnancy can affect the fetus and result in long-term vulnerability to abnormalities in the child's brain development. This study aimed to determine the impact of prenatal Covid-19 on the development of toddlers. The research method uses observational cross-sectional analysis. Secondary data on confirmed Covid-19 mothers were obtained from Prof. RD Kandou General Hospital, Wolter Monginsidi Hospital, and Manado Adventist Hospital. Primary data on toddler development using the KPSP Development Questionnaire instrument were obtained from 10 Community Health Centers in Manado City with a total of 92 respondents for two, 46 respondents were born to mothers with Covid-19 during the prenatal period and 46 toddlers were born to mothers who were not confirmed to have Covid-19 during the prenatal period. The results showed that there was no significant effect with a p-value of 0.562 for toddlers born to Covid-19 mothers on impaired gross motor, fine motor, socialization, and independence, speech, and language development. Based on the results of the study it can be concluded that both toddlers born to Covid-19 mothers and toddlers who were not born to Covid-19 mothers are at risk of experiencing growth disturbances, especially toddlers born during the Covid-19 pandemic because there could be long-term effects that could occur in infants who are exposed to the virus during the prenatal/intrauterine period.
The Effectiveness of Web-Based Education Women Health (E-WoHealth) on The Level of Skills of Pregnant Women About Breast Care
Authors: Anggraeni Ni Made Dewi , Ahmad Mardiana , Baso Yusring Sanusi , Jusuf Elizabeth C. , Rafiah Sitti , Nurdin Jibril
Published: May 2024

The report from the Bone Bolango District Health Office shows that the prevalence of exclusive breastfeeding for the last 3 years has decreased, namely in 2019 by 28.3%, in 2020 by 16%, and in 2021 it has decreased by 12.7%. Many factors cause the low rate of exclusive breastfeeding in children, one of which is caused by poor knowledge about breastfeeding. Based on these problems, media is needed to increase the skills of pregnant women regarding breast care. This research aims to create a web platform called E-WoHealth which can improve pregnant women's skills regarding breast care. This research used Research and Development (R&D) methods. Then to see the difference before and after the use of Web-based E- WoHealth on the skill level of pregnant women in performing breast care using the Pre-Experimental Design (One group pretest-posttest design). This study was carried out in the working area of the Kabila Health Center, Oluhuta, Kec. Kabila, Bone Bolango Regency, Gorontalo. Population in research tian namely third-trimester pregnant women in the working area of the Kabila Health Center, Bone Bolango Regency, as many as 60. Data collection techniques, documentation, questionnaires, tests, and observations. The results showed that the results of the web-based E-WoHealth feasibility test were in the very feasible category, and the statistical test results showed that the web-based E-WoHealth was effective in increasing pregnant women's skill regarding breast care with a p-value of 0.000 (p<0.05). Thus, education on breast care using web-based E-WoHealth is feasible and effective in increasing the skills of pregnant women before and after the intervention. It is hoped that the health office can socialize this platform with pregnant women to raise awareness about breast care.
Effectiveness of Online Mindfulness-Based Intervention on Depression in Pregnancy
Authors: Kundarti Finta Isti , Titisari Ira , Kiswati Kiswati , Jamhariyah Jamhariyah , Rahayu Dwi Estuning
Published: May 2024

The high prevalence of depression in developed and developing countries requires a relevant intervention to suppress its incidence. Mindfulness-based intervention is given online as a new complementary intervention that can help reduce symptoms of depression. This study aimed to determine the effectiveness of online mindfulness-based interventions in reducing depressive symptoms in pregnancy. This research method used a randomized control trial, with 66 participants consisting of the mindfulness-based Intervention (MBI) group of 33 participants and the control group of 33 participants. The MBI intervention was provided for eight weeks online. The study uses simple random sampling. Depression was assessed using DASS 42. Data were tested using the Mann-Whitney U Test and t-test and processed with SPSS version 23. The results showed that there was a significant decrease in depression levels in the online MBI group after being given intervention compared to the control group (7.55 ± 2.181 vs 11.00 ± 2.345) p=0.000. Mindfulness-based intervention online can reduce depressive symptoms in pregnant women, so that the intervention becomes a feasible, cheap and easy intervention for pregnant women in improving mental health. In the future, this research can develop other types of complementary interventions to improve maternal and fetal health.
Characteristics and Lifestyle Related to Blood Sugar Levels in Type 2 Diabetes Mellitus Patients
Authors: Maria Ida Leida
Published: May 2024

Type 2 diabetes mellitus has been a prominent public health issue today. Globally, an estimated 462 million people are affected by type 2 diabetes, equivalent to 6.28% of the world's population. Globally, an estimated 462 million people are affected by type 2 diabetes, equivalent to 6.28% of the world's population. In Asia, especially Indonesia, the number of cases is expected to increase to 21.3 by 2030 in Indonesia. Type 2 diabetes is determined by blood sugar level, which affected by many factors including patients’ characteristics and lifestyle habits such as physical activity and diet. The Purpose of this research is to find the association between age, sex, education level, employment status, duration of disease, obesity, hypertension, diet, and physical activity with the blood glucose level of type 2 diabetic patients.  This research used cross-sectional study design. The population is type 2 diabetes mellitus patients The population is type 2 diabetes mellitus patients who are spread over three areas of the city of Makassar, at the city center, suburban health center and coastal health center, total sample size of 273 patients The research was conducted sampling for 2 months via interview. The research instruments used were IPAQ and FFQ. The data analysis technique used is univariate and bivariate analysis,  using chi-square. The results of this study indicate that found correlation between the variables. Lifestyle were found associated most with blood sugar level. Findings of the research found association between duration (p=0.003), obesity (p=0.000), hypertension (p=0.048), diet (p=0.000), and physical activity (p=0.000) with blood sugar levels. Meanwhile, age (p=0.461), gender (p=0.431), education level (p=0.357), working status (p=0.522), found not associated with blood sugar levels in patients with type 2 diabetes. The conclusion is duration Obesity, hypertension, diet, and physical activity were found associated with blood glucose level in type 2 diabetic patients. Patients with type 2 diabetes are expected to maintain blood sugar level by implementing healthy lifestyle. This includes regular physical activity and balanced diet.
Spatial Analysis of the Occurrence of Multi-Drug Resistance (MDR) Escherichia coli in Pet Dogs in Kupang City
Authors: Kallau Novalino H.G. , Sanam Maxs U.E. , Utami Tri , Sitompul Yeremia Y.
Published: May 2024

Antibiotic resistance is an important health problem and a threat to public health. Dogs as pets can be both spreaders and reservoirs of antibiotic-resistant bacteria. Based on spatial analysis, this study aims to determine the distribution pattern of multidrug resistance (MDR) Escherichia coli found in pet dogs in Kupang City. The spatial analysis method used is based on the convex hull technique, elementary analysis of disease, and the Nearest Neighbour Index (NNI). Information on antibiotic-resistant E. coli has been obtained from the laboratory analysis results and secondary data obtained for spatial analysis. The results of this study have shown that the distribution pattern of the incidence of MDR E. coli in the City of Kupang in 2020 is a clustered pattern with the Nearest Neighbor Index (NNI) value of 0.783 which is higher than the NNI AMR E. coli in the City of Kupang of 0.763. The incidence of MDR E. coli that has occurred in domesticated dogs takes place with a prevalence rate of 35% in an area of 5079 Ha. These results have shown that the incidence of MDR E. coli has spread to several areas in Kupang City and is a threat to public health. It requires appropriate prevention and control measures by implementing good hygiene and sanitation in the relationship between humans and their pets.
The Impact of Aging on the Quality of Sperm in White Rats (Rattus Norvegicus) Wistar Strain
Authors: Widiastini Luh Putu , Karuniadi I Gusti Agung Manik , Tangkas Made
Published: May 2024

Due to the reproductive aging process, the testes, epididymis, and other reproductive organs gradually lose all their physiological capabilities. This study aimed to determine the effect of aging on the sperm quality of Wistar rats (Rattus Norvegicus). The research design is quantitative and descriptive. This study used white male rats (Rattus norvegicus) of the Wistar strain aged 19–20 months. The number of samples was 18 individuals, with a purposive sampling technique following the inclusion and exclusion criteria. Mice were put to sleep on the seventh day, then the cauda epididymis and testes were separated, and a media container was used to accommodate them. The spermatozoa produced were then examined for their motility, morphology, and viability. The results showed that the range, mean, and standard deviation of progressive motility of spermatozoa was 5.83%, 217% ± 1.87%, normal morphology was 39.17%, 61.6% ± 9.57%, and spermatozoa viability was 19.50%, 74.6 ± 5.83%. There was a progressive decrease in motility, but morphology was expected, and spermatozoa viability was within normal limits. This study concludes that aging affects spermatozoa motility, but the morphology and viability of spermatozoa are still within normal limits. Future studies should do genetic analysis to determine how hereditary factors affect the quality of sperm in aged white rats and compare the results to those of young rats to identify changes in sperm quality.
The Impact of Stigma on Medication Compliance for Tuberculosis Patients at the Health Center in Bandar Lampung City
Authors: Umar Ernawati , Romadhon Rhinaldy Danara , Yupartini Lisnawati , Darajat Ahmad
Published: May 2024

Tuberculosis, a lethal infectious illness, is known as the ninth leading cause of mortality worldwide. Self-stigma might emerge from the social stigma that Tuberculosis patients experience in their social environment. Stigma is triggered by five factors: self-isolation, supportive views, discrimination experiences, social withdrawal, and stigma resistance. The purpose of this study was to see how Tuberculosis stigma affected medication adherence at Bandar Lampung City Health Center. This study is a quantitative study employing a case-control technique. The simple random sampling technique was utilized with a total sampling of up to 54 respondents who fulfilled the inclusion criteria. Data collection through the completion of the questionnaire. A bivariate chi-square test and a multivariate logical regression test were utilized to analyze the data. The findings indicated age, sex, marital status, education, occupation, self-isolation, views of support, experience of discrimination, social withdrawal, and rejection Stigma: p-value of self-isolation = 0.000, views of support = 0.000, experience of discrimination = 0.007, social withdrawal = 0.001, resistance to stigma = 0.000. The value of the logistic regression equation is Y = a + b1 X + b2 X + b3 X. This study concludes that stigma resistance is the most influential factor impacting medication adherence. This study suggests that tuberculosis sufferers do not withdraw, may contribute to society, socialize more, get along conveniently, and overcome stigma by thinking positively.
Attitude Factor in Increasing Intention to Come to The Integrated Service Post
Authors: Suparji Suparji , Surtinah Nani , Nugroho Heru Santoso Wahito , Sunarto Sunarto
Published: May 2024

Integrated Healthcare Center (integrated service post) is the government's effort to make it easier for the Indonesian people to obtain maternal and child health services. The main problem of this research is the low number of visits by toddlers to Integrated Healthcare Center service posts. This study analyses the relationship between attitudes about the Integrated Healthcare Center and intention to come to the Integrated Healthcare Center. The researcher wants to apply the theory of planned behaviour that intentions influence behaviour while attitudes towards an object, subjective norms and behavioural control influence intentions. Rangacanga correlation research, with a cross-sectional approach. The population of mothers under five is 135 people, and the sample size is 101 people. The sampling technique used is simple random sampling. The data collection instrument was in the form of attitude and intention questionnaires. The independent variable is attitude, and the dependent variable is the intention to visit the Integrated Healthcare Center. In statistical analysis with the Pearson product-moment statistical test, the error rate is set at 0.05. The results showed that 51.28% of mothers under five had a positive attitude, and 51.28% had positive intentions. Statistical test results obtained p: 0.00 <α 0.05 concluded that there is a relationship with the correlation coefficient value of 0.670. This study concludes that the mother's positive attitude positively impacts Integrated Healthcare Center visits by mothers of toddlers. So, it is suggested that community leaders or health workers motivate and empower the community to participate in Integrated Healthcare Center activities.
Factors Affecting the Meaning of Life in Breast Cancer Patients at Malang City, Indonesia
Authors: Supriati Lilik , Nova Renny , Ahsan Ahsan , Rodli Muhammad , Rismayanti I Dewa Ayu , Kapti Rinik Eko
Published: May 2024

The meaning of life is considered to affect breast cancer patients positively. Finding meaning in life is key to improving well-being during and after experiencing a traumatic event such as cancer. Previous research was still rare to explore the factors affecting the meaning of life in breast cancer patients. The study aimed to analyze the factors influencing the meaning of life of breast cancer patients.  This study was an analytical observational method with a cross-sectional design. The inclusion criteria of the respondents were breast cancer patients who had obtained at least one cycle of chemotherapy. We used purposive sampling, and the total sample in this study was 135 respondents. Questionnaires were used to collect the data. Data were analysed by multivariate test, namely a linear regression test with a significance level of p ≤ 0,05. The result showed only two variables affect the meaning of life, communication of health workers and spirituality, respectively. The strongest variable was the communication of health workers.  The equation from the analysis showed that 11 % explained the phenomenon. The spirituality and communication of health workers positively affected the meaning of life. Application of therapeutic communication as well as spiritual support are needed in nurses to patients while undergoing therapy. Therefore, nurses must pay attention to spirituality and good therapeutic communication when providing patient services.
Comparison of Indicators of Families at Risk of Stunting in High-Income Regencies and Low-Income Regencies in East Nusa Tenggara Province
Authors: Lydia Mona , Lada Christina Olly , Roga Anderias Umbu
Published: May 2024

Stunting is a condition of failure to thrive in children due to chronic malnutrition. Early detection of various indicators of families at risk of stunting is an important effort in preventing stunting in the community. This research aims to analyze the comparison of indicators of families at risk of stunting in districts with high per capita income and districts with low per capita income. The Method is secondary data research. The data source is the results of the 2021 National Population and Family Planning Agency (BKKBN) Survey of East Nusa Tenggara Province. The sample size is 878 families divided into 439 families at risk of stunting from high-income districts per capita, and 439 families at risk of stunting from low-income districts. Sampling was carried out by stratification sampling technique or layered sampling. The independent variable is an indicator of a family at risk of stunting, namely the age of the mother, education, fixed income, number of children, sources of drinking water, proper latrines, and habitable houses, and the dependent variable is income per capita in the district where the family lives. The data were identified and statistically analyzed using bivariate Chi-Square test and multivariate logistic regression with a significant p-value <0.05. The result show that the chi-square test mother's age (p = 0.31), mother's education (p=0.77), fixed family income (p=0.00), number of children (p=0.17), availability of water sources clean (p=0.67), healthy latrine ownership (p=0.82), and healthy home ownership (p=0.03). Logistic regression test results for family fixed income (p=0.00), healthy home (p=0.07). The Conclusion is mother's age, mother's education, number of children, availability of clean water sources, ownership of latrines, and healthy homes are the main indicators of the risk of stunting in families. This indicator has no difference between families living in areas with low per capita income, and families living in areas with high incomes.
Risk Factors Related to Stunting
Authors: Oktaviani Tri Anugrah , Suwarni Linda , Selviana Selviana
Published: May 2024

Childhood stunting, or low height for age, continues to be a concern for world health since it raises the possibility of both mortality and growth and development disorders. West Kalimantan province ranks seventh with the highest prevalence of 29.8% by 2021. But little is known about Pontianak's children's stunting risk factors, especially in the UPT Puskesmas Pal Lima (one of the community health centers with a high prevalence of stunting). The study aimed to determine risk factors associated with stunting in the UPT Puskesmas Pal Lima, such as high-risk pregnant women, pregnant women with chronic energy deficiency, communication of educational information about stunting, occupancy density, and age of pregnant women in the UPT Puskesmas Pal Lima. Cross-sectional study design was used. The research was conducted in February-March 2023. The population in this study were all stunted toddlers in the UPT work area of the Pal Lima Health Center. Sampling used quota sampling with all 75 stunted toddlers. Data analysis used univariate and bivariate analysis (chi square test with 95% CI). This research found that 61,3% with high risk pregnant women, 21,3% with chronic energy deficiency, 52%  not exposed to information communication and education about stunting, 32% occupancy density were not qualified, 48% risk at age of pregnant mothers, 32% severe stunting and 68% stunting. There was a significant relationship between high-risk pregnant women (p-value = 0,015), pregnant women with chronic energy deficiency (p-value = 0,001), the information communication and education about stunting (p-value = 0,046), occupancy density (p-value = 0,043), and the age of pregnant women (p-value = 0,049), and the incidence of stunting in toddlers in the working area of UPT Puskesmas Pal Lima, West Pontianak District. Based on the results of this study can be used as a basis for the primary prevention of stunting in pregnant women.
Analisis Kemampuan Siswa dalam Menyelesaikan Soal High Order Thinking ditinjau dari Kemampuan Awal Matematis Siswa
Authors: Gais Zakkina , Afriansyah Ekasatya Aldila
Published: May 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kemampuan awal matematis siswa terhadap penyelesaian soal-soal high order thinking ditinjau dari soal analisis, soal evaluasi, soal mencipta dan secara umum. Penelitian ini pun bertujuan untuk mengetahui kemampuan siswa dalam menyelesaikan soal-soal high order thinking serta untuk mengetahui faktor-faktor yang menyebabkan siswa keliru dalam  menyelesaikan soal-soal high order thinking. Metode penelitian yang digunakan adalah metode campuran dengan jenis embedded concurrent. Dari hasil penelitian diperoleh terdapat pengaruh kemampuan awal matematis siswa terhadap penyelesaian soal high order thinking dalam segala aspek. Siswa dikategorikan mampu menyelesaikan soal-soal high order thinking. Faktor-faktor yang menyebabkan siswa keliru dalam  menyelesaikan soal-soal high order thinking diantaranya adalah kurang teliti dalam proses pengerjaan soal, kemampuan awal matematis siswa yang rendah, proses yang dilalui selama pembelajaran tidak maksimal, kurangnya pemahaman siswa terhadap soal,  ketidaklengkapan dalam membaca soal dan kurangnya perhatian dari orang tua.
This research aims to know the effect of prior mathematical students' ability to solve on high order thinking questions looked by analysis question, evaluation question, creating question and genera question. This research also aims to know about students' ability in solving high order thinking question and to know about the factors that cause students to be wrong in solving high order thinking questions. The research method that used is mixed method with embedded concurrent type. From the result of the research, it is gotten there is an effect of prior mathematical students' ability to solve high order thinking question in all aspects. Students are categorized able to solve high order thinking questions. The factors that cause student to be wrong in solving high order thinking question are less careful in the process of solving the question, the prior mathematical student's ability is low, the process traversed during learning is not maximal, the lack students understanding to the question, incompleteness in reading the questions and the lack of attention of their parents.
Pengembangan Lembar Kegiatan Siswa Berbasis Penemuan Terbimbing pada Materi Peluang untuk Siswa Kelas XI IPA SMA Adabiah 2 Padang
Authors: Nengsih Sefrida , Septia Tika , Febriana Rina
Published: May 2024

Penelitian ini dilatarbelakangi oleh adanya siswa yang belum memahami materi peluang dan penyajian materi pada LKS belum membimbing siswa menemukan konsep secara mandiri. Penelitian ini bertujuan untuk menghasilkan LKS berbasis penemuan terbimbing  pada materi peluang untuk siswa kelas XI IPA SMA Adabiah 2 Padang yang valid, praktis dan efektif. Jenis penelitian ini adalah penelitian pengembangan dengan menggunakan model Plomp yang terdiri atas 3 fase yaitu preliminary research, prototyping phase, dan assessment phase. Tahap preliminary research terdiri dari wawancara kepada siswa dan guru, analisis silabus, dan analisis buku teks. Tahap prototyping phase yaitu merancang sistematika dan struktur LKS, penyusunan prototipe, evaluasi diri, tinjauan ahli, evaluasi satu-satu dan evaluasi kelompok kecil. Tahap assessment phase yaitu uji kelompok besar terhadap satu kelas yaitu kelas XI IPA 3 sebagai kelas ekperimen.Hasil penelitian menunjukkan LKS berbasis penemuan terbimbing valid, praktis, dan efektif dalam meningkatkan hasil belajar dan memotivasi siswa.
This research is motivated by the existence of students who do not understand the material opportunities and presentation of the material on the LKS has not led the students find the concept independently. This study aims to produce LKS based on guided discovery on the material opportunities for students of class XI IPA SMA Adabiah 2 Padang valid, practical and effective. This type of research is development research using a plomp model consisting of 3 phases, namely preliminary research, prototyping phase, and assessment phase. The preliminary research stage consists of interviews to students and teachers, syllabus analysis, and textbook analysis. Phase prototyping phase is designing LKS systematics and structures, prototype arrangement, self-evaluation, expert review, one-to-one evaluation and small group evaluation. The assessment phase is a large group test of one class that is class XI IPA 3 as the experimental class. The result of the research shows that LKS based on the discovery of guidance is valid, practical, and effective in improving learning outcomes and motivating students.