bluuebunny/crossref_metadata_2025 huggingface dataset:
Rhein alleviates MPTP-induced Parkinson’s disease by suppressing neuroinflammation via MAPK/IκB pathway
Authors: Qin Xin , Wang Shu , Huang Juan , Hu Binbin , Yang Xingyan , Liang Liying , Zhou Rui , Huang Wei
Published: June 2024

Background

Parkinson’s disease (PD) is a common neurodegenerative disease with a rapid increase in incidence in recent years. Existing treatments cannot slow or stop the progression of PD. It was proposed that neuroinflammation leads to neuronal death, making targeting neuroinflammation a promising therapeutic strategy. Our previous studies have demonstrated that rhein protects neurons in vitro by inhibiting neuroinflammation, and it has been found to exhibit neuroprotective effects in Alzheimer’s disease and epilepsy, but its neuroprotective mechanisms and effects on PD are still unclear.

Methods

PD animal model was induced by 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP). ELISA, RT-qPCR, western blot and Immunofluorescence were used to detect the levels of inflammatory cytokines and M1 polarization markers. The protein expression levels of signaling pathways were measured by western blot. Hematoxylin–eosin (HE) staining showed that rhein did not damage the liver and kidney. Two behavioral tests, pole test and rotarod test, were used to evaluate the improvement effect of rhein on movement disorders. The number of neurons in the substantia nigra was evaluated by Nissl staining. Immunohistochemistry and western blot were used to detect tyrosine hydroxylase (TH) and α-synuclein.

Results

Rhein inhibited the activation of MAPK/IκB signaling pathway and reduced the levels of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) and M1 polarization markers of microglia in vivo. In a mouse model of PD, rhein ameliorated movement disorders, reduced dopaminergic neuron damage and α-synuclein deposition.

Conclusion

Rhein inhibits neuroinflammation through MAPK/IκB signaling pathway, thereby reducing neurodegeneration, α-synuclein deposition, and improving movement disorders in Parkinson’s disease.
Correlation and consistency between two detection methods for serum 25 hydroxyvitamin D levels in human venous blood and capillary blood
Authors: Xing Yutong , Wang Kaixi , Ma Xinyu , Zhang Huifeng , Tian Xiaoyu
Published: June 2024

Introduction

The study assessed the correlation and concordance of 25-hydroxyvitamin D [25(OH)D] levels in capillary and venous plasma collected simultaneously after vitamin D3 supplementation in 42 healthy adults. They were randomly divided into three groups by random number table method. Group A took 1,000 IU vitamin D3 daily, group B took 10,000 IU vitamin D3 every 10 days, and group C took 30,000 IU vitamin D3 every 30 days until the end of the 12th month. Venous blood serum 25(OH)D level was detected by chemiluminescence immunoassay (CLIA) and mass spectrometry (LC-MS) at day 1, day 14, day 28, month 6, and month 12 respectively, the capillary blood serum 25(OH)D level was detected by chemiluminescence immunoassay (CLIA) at the same time. Pearson correlation analysis and linear regression analysis were employed to investigate the relationship and transformation equation between the findings of the two samples and the results obtained from different detection methods within the same sample. The Bland-Altman method, Kappa analysis, and receiver operating characteristic (ROC) curve were utilized for assessing consistency, sensitivity, and specificity.

Results

The three groups all reached a stable peak at 6 months, and the average levels of the three groups were 49.21, 42.50 and 43.025 nmol/L, respectively. The average levels of group A were higher than those of group B and group C (P < 0.001). The mean values of serum 25(OH)D measured by LC-MS and CLIA in 42 healthy adults were 45.32 nmol/L and 49.88 nmol/L, respectively, and the mean values of 25(OH)D measured by LC-MS in capillary blood were 52.03 nmol/L, and the difference was statistically significant (P < 0.001). Pearson correlation analysis showed that the linear fitting formula of scatter data was as follows: venous 25(OH)D concentration (nmol/L) = 1.105 * capillary 25(OH)D concentration −7.532 nmol/L, R2 = 0.625. Good agreement was observed between venous and corrected capillary 25(OH)D levels in clinical diagnosis (Kappa value 0.75). The adjusted serum 25(OH)D in capillary blood had a high clinical predictive value.

Conclusions

The agreement between the two methods is good when the measured 25(OH)D level is higher. Standardized capillary blood chemiluminescence method can be used for 25(OH)D detection.
Seven-day dietary nitrate supplementation clinically significantly improves basal macrovascular function in postmenopausal women: a randomized, placebo-controlled, double-blind, crossover clinical trial
Authors: Delgado Spicuzza Jocelyn M. , Gosalia Jigar , Zhong Liezhou , Bondonno Catherine , Petersen Kristina S. , De Souza Mary Jane , Alipour Elmira , Kim-Shapiro Daniel B. , Somani Yasina B. , Proctor David N.
Published: June 2024

Introduction

Cardiovascular disease (CVD) is the leading cause of death in women, with increased risk following menopause. Dietary intake of beetroot juice and other plant-based nitrate-rich foods is a promising non-pharmacological strategy for increasing systemic nitric oxide and improving endothelial function in elderly populations. The purpose of this randomized, placebo-controlled, double-blind, crossover clinical trial was to determine the effects of short-term dietary nitrate (NO3−) supplementation, in the form of beetroot juice, on resting macrovascular endothelial function and endothelial resistance to whole-arm ischemia–reperfusion (IR) injury in postmenopausal women at two distinct stages of menopause.

Methods

Early-postmenopausal [1–6 years following their final menstrual period (FMP), n = 12] and late-postmenopausal (6+ years FMP, n = 12) women consumed nitrate-rich (400 mg NO3−/70 mL) and nitrate-depleted beetroot juice (approximately 40 mg NO3−/70 mL, placebo) daily for 7 days. Brachial artery flow-mediated dilation (FMD) was measured pre-supplementation (Day 0), and approximately 24 h after the last beetroot juice (BR) dose (Day 8, post-7-day BR). Consequently, FMD was measured immediately post-IR injury and 15 min later (recovery).

Results

Results of the linear mixed-effects model revealed a significantly greater increase in resting FMD with 7 days of BRnitrate compared to BRplacebo (mean difference of 2.21, 95% CI [0.082, 4.34], p = 0.042); however, neither treatment blunted the decline in post-IR injury FMD in either postmenopausal group. Our results suggest that 7-day BRnitrate-mediated endothelial protection is lost within the 24-h period following the final dose of BRnitrate.

Conclusion

Our findings demonstrate that nitrate-mediated postmenopausal endothelial protection is dependent on the timing of supplementation in relation to IR injury and chronobiological variations in dietary nitrate metabolism.

Clinical trial registration

https://classic.clinicaltrials.gov/ct2/show/NCT03644472
The interaction between estimated glomerular filtration rate and dietary magnesium intake and its effect on stroke prevalence: a cross-sectional study spanning 2003–2018
Authors: Liu Chunhua , Qiu Linan , Zhang Yuanyuan , Chen Liping , Wang Huaqiang , Lin Huajian , Tao Yongjun , Ye Haiqin
Published: June 2024

Background

Despite the known associations of dietary magnesium intake and estimated glomerular filtration rate (eGFR) with cardiovascular diseases, their combined effects on stroke risk remain unclear. Therefore, this study aims to explore the associations of dietary magnesium intake and eGFR with stroke risk.

Methods

The National Health and Nutrition Examination Survey (NHANES) data of 37,637 adult participants (≥18 years) from 2003 to 2018 was analyzed. Dietary magnesium intake was categorized as low (≤ 254 mg/day) and normal (> 254 mg/day) based on experimental data. Multiple logistic regression analyses and interaction tests were conducted to assess the associations of dietary magnesium intake and eGFR with stroke risk, with a focus on the interaction between different chronic kidney disease (CKD) stages based on eGFR levels and dietary magnesium intake. Additional analyses included multiplicative interaction analysis, restricted cubic spline analysis, and subgroup evaluations by age, sex, and ethnicity.

Results

Dietary magnesium intake and eGFR were inversely correlated with the risk of stroke. Participants with low dietary magnesium intake had a higher stroke risk than those with normal magnesium intake (odds ratio [OR] 1.09, 95% confidence interval [CI]: 1.03–1.42). Likewise, low eGFR was associated with an elevated stroke risk compared with normal eGFR (OR 1.56, 95% CI: 1.15–2.13). Furthermore, the two factors showed a multiplicative interaction effect on stroke risk (OR 1.05, 95% CI: 1.01–1.09). We observed a significant interaction between stage G3 CKD and low dietary magnesium intake (OR 1.05, 95% CI: 1.01–1.09), suggesting a potential association with stroke risk. However, similar associations were not observed for stages G4 and G5, possibly due to the smaller number of participants with G4 and G5 CKD. The restricted cubic spline analysis revealed a non-linear relationship between dietary magnesium intake, eGFR, and stroke risk. The interaction between magnesium deficiency and low eGFR persisted in participants aged >60 years, as well as in females, non-Hispanic Black people, and people of other races.

Conclusion

Dietary magnesium intake and eGFR correlate negatively with stroke prevalence. Moreover, there was an interaction between dietary magnesium intake and stroke prevalence across different CKD stages. Further large-scale prospective studies are needed to analyze the potential relationship between dietary magnesium intake, eGFR, and stroke.
Bronchial artery chemoembolization in the treatment of refractory central lung cancer with atelectasis
Authors: Liu Yujin , Zhang Xiumei , Zhang Fenxiang , Song Weixiang
Published: June 2024

Objective

This study aims to explore the clinical application of bronchial artery chemoembolization (BACE) in managing refractory central lung cancer with atelectasis.

Methods

The retrospective case series includes patients diagnosed with refractory central lung cancer and atelectasis who underwent BACE treatment at Yueyang Integrated Traditional Chinese and Western Medicine Hospital, affiliated with Shanghai University of Traditional Chinese Medicine, from January 2012 to December 2021.

Results

All 30 patients with lung cancer successfully underwent BACE procedures. Their ages ranged from 62 to 88 years, with an average age of 67.53. The treatment interval was 21 days, and the treatment cycle ranged from 2 to 12 times, averaging 4.13 times. During the BACE procedures, the Karnofsky Performance Status (KPS) score after 2 to 3 BACE cycles showed a significant improvement (82.0 ± 10.1 vs 68.3 ± 14.0, P < 0.001) than that of before BACE. Only nutritional support and symptomatic treatment were performed after BACE, and no major hemoptysis were observed. During follow-up, 23 cases resulted in mortality, while seven survived. The median progression-free survival (PFS) and overall survival (OS) were 7.0 (95% CI: 4.6–9.4) and 10.0 (95% CI: 6.2–13.8) months, respectively, with 1-, 2-, and 3-year survival rates of 84.0%, 53.5%, and 11.3%, respectively. Eight cases exhibited bronchial recanalization and relief of atelectasis. According to the RECIST scale, there were 4 cases of complete response (CR), 16 cases of partial response (PR), 9 cases of stable disease (SD), and 1 case of progressive disease (PD). No serious adverse events were reported.

Conclusion

BACE might be a safe intervention for refractory central lung cancer accompanied by atelectasis. The procedure exhibits satisfactory outcomes in tumor control, atelectasis relief, and enhancement of quality of life, warranting further investigation.
Surgical management of a foramen magnum tumor via a far-lateral approach using an oblique straight incision: a case series report and technique note
Authors: Bai Jie , Jian Zhi-heng , Chen Peng , Cheng Ye , Wang Ya-ming , Chen Gang , Xiao Xin-ru
Published: June 2024

Objective

To review our single-institution experience in the surgical management of foramen magnum tumors via a far-lateral approach using an oblique straight incision.

Methods

From October 2023 to January 2024, four cases of tumors in the foramen magnum area treated at the Capital Medical University-affiliated XuanWu hospital neurosurgery department were involved in this study. All cases were managed with a far-lateral approach using an oblique straight incision. We retrospectively reviewed the clinical and imaging data, as well as the surgical strategies employed.

Results

Three cases of foramen magnum meningiomas and one case of glioma of the ventral medulla. All cases underwent a far-lateral approach using an oblique straight incision; all cases had a gross total resection, and the wounds healed well without cerebral fluid leakage or scalp hydrops. Except for one case of right foramen magnum meningioma, which had dysphagia and pneumothorax, the other cases were without any postoperative complications.

Conclusion

A far-lateral approach using an oblique straight incision can preserve muscle integrity and minimize subcutaneous exposure, allowing for complete anatomical reduction of muscles. This craniectomy method is simple and replicable, making it worthy of further clinical practice.
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the ileum in an adult presenting with intussusception: a case report and literature review
Authors: Da Binlin , Zhang Juanjuan , Zhu Feng , Wang Zhiming , Diao Yanqing
Published: June 2024

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL), also known as MALT lymphoma, is an extranodal multiorgan-invasive proliferative lymphoma composed of small B cells with variable morphology. It most commonly occurs in the digestive tract, with a high prevalence in the stomach, but EMZL originating in the small intestine is rare and lacks specificity in clinical manifestations, which makes it easy to be misdiagnosed. Herein, we report a rare case of small intestinal EMZL presentation as intussusception in a 32-year-old man. A colonoscopy performed at the local hospital revealed a pedicled polyp about 5 cm × 5 cm in size with a rough surface, and hyperemia was seen in the ileocecal region. He was admitted to our hospital for a polypectomy. A contrast-enhanced computed tomographic (CT) scan suggested ileocolic intussusception, which was subsequently confirmed by a colonoscopy in our hospital. Adult intussusception is relatively rare, with 90% of cases having a known causative mechanism and 40% of cases caused by primary or secondary malignancies. Therefore, we performed a laparoscopic-assisted right hemicolectomy for the patient. The resected specimen showed that the terminal ileum was intussuscepted into the ascending colon, and the intussusception was hyperemia and edema. A 2.5 cm × 2.5 cm × 1.5 cm mass was seen at the end of the intussusception. Postoperative pathology revealed that the mass was EMZL, partially transformed into a large B-cell lymphoma. The patient was transferred to the hematology department and completed a PET-CT showing postoperative manifestations of primary intestinal lymphoma, Lugano staging IE2. Although EMZL was an indolent lymphoma and the patient was in the early stages, the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen was given in view of the histological transformation. The patient is in regular follow-up. This was a rare case of small intestinal mass due to EMZL presented as intussusception in adults, which highlighted laparoscopic-assisted enterectomy as a potential therapeutic approach in the multidisciplinary collaborative therapy of small intestine EMZL.
Liposomes have a direct effect on multiple myeloma: a Mendelian randomization study
Authors: Zhong Yingbin , Li Yanhao , Sun Weipeng , Xiao Mingfeng
Published: June 2024

Background

Multiple myeloma (MM), a malignant disease of plasma cells originating in the bone marrow, is influenced significantly by genetic factors. Although plasma liposomes have been linked to MM, the nature of their potential causal relationship remains to be elucidated. This study aims to explore this relationship using Mendelian randomization (MR) analysis.

Methods

Liposome-associated genetic instrumental variables (IVs) were identified from plasma lipidomics data of 7,174 Finnish individuals within a Genome-Wide Association Study (GWAS) pooled database. A MM pooled dataset was sourced from a GWAS meta-analysis encompassing 150,797 individuals, including 598 MM patients and 218,194 controls. These IVs underwent MR analysis, adhering to strict criteria for correlation, independence, and the exclusion of confounders. The inverse variance weighted (IVW) method, MR-Egger method, weighted median (WM) method, and simple median were utilized for MR analysis assessment, alongside Cochran’s Q test, MR-Egger intercept, MR-Pleiotropy Residual Sum and Outlier (MR-RESSO) method, and leave-one-out analysis for evaluating heterogeneity, multiplicity, and instrumental bias.

Results

The study identified 88 significant, independent single nucleotide polymorphisms (SNPs) as IVs for MR analysis, each with an F-statistic value above 10, indicating robustness against weak instrument bias. IVW analysis revealed associations between six plasma liposome components and MM risk (p < 0.05). Phosphatidylinositol (16:0_18:1) serum levels (odds ratio [OR] = 1.769, 95% confidence interval [CI]: 1.132-2.763, p = 0.012) and triacylglycerol (56:4) levels (p = 0.026, OR = 1.417, 95% CI: 1.042-1.926) were positively correlated with the risk of multiple myeloma development. Phosphatidylethanolamine (18:0_20:4) (p = 0.004, 95% CI: 0.621-0.916, OR = 0.754), phosphatidylcholine (18:2_20:4) (p = 0.004, OR = 0.680, 95% CI: 0.519-0.889), sterol ester (27:1/18:3) levels (p = 0.013, OR = 0.677, 95% CI: 0.498-0.922), and phosphatidylcholine (O-18:2_20:4) levels (OR = 0.710, 95% CI: 0.517-0.913, p = 0.033) were negatively associated with the risk of developing multiple myeloma. The Cochran’s Q test did not detect statistical method heterogeneity, nor did the MR-RESSO test or the MR-Egger intercept detect horizontal pleiotropy; leave-one-out analyses confirmed the absence of bias from individual SNPs

Conclusions

Our findings suggest a complex relationship between plasma liposome components and MM risk. Elevated serum levels of triacylglycerol and phosphatidylinositol are positively associated with MM risk, while certain phospholipids and sterol esters offer a protective effect. This study provides valuable insights into the clinical relevance of liposomes in the pathology of multiple myeloma.
A pediatric patient with bilateral tracheobronchial foreign body successfully treated using surgical intervention with extracorporeal circulation: case report and literature review
Authors: Xu Li-Qiang , Liu Qiang , Zeng Min , Yan Hui-Zhi , Hu Nan , Zhang Qun-Xian , Guo Qiang , Guo Jia-Long , Zhang Jun
Published: June 2024

Unilateral Tracheobronchial foreign body (TFB) present a common clinical disease, whereas bilateral TFB is a rare and acute condition associated with high mortality rates. This case study discusses a pediatric patient hospitalized due to respiratory distress following accidental ingestion of peanut kernels. A plain chest CT scan revealed obstructive emphysema in the right main bronchus and a foreign body at the opening of the left main bronchus. Surgical removal of the bilateral TFB under extracorporeal circulation resulted in a successful postoperative recovery, leading to discharge on the 9th day. A comprehensive literature search was conducted across databases including PubMed, Web of Science, EMBASE, Cochrane Library, and CNKI, spanning publications from January 2014 to October 2023, utilizing keywords “bronchial foreign body” and “Peanut”. After deduplication and relevance screening, 9 pertinent literature sources were included. The objective of this study is to enhance clinical practitioners' understanding of TFB management and improve diagnostic and treatment capabilities through analysis of age of onset, clinical manifestations, diagnosis, and treatment approaches in critically ill pediatric patients.
The prevalence of polypharmacy and hyper-polypharmacy among middle-aged vs. older patients in Saudi Arabia: a cross-sectional study
Authors: Alqurain Aymen A. , Albaharnah Murtada , Al Zayer Samanah , Ameer Luma , Ghosn Sherihan , Al-Shaibi Samaher , Algoraini Marwa , Aldhafeeri Amal , Alyusuf Danah A. , Alshnbari Afnan , Alsaffar Nida , Al-Matouq Jenan , Al Khamees Mohammed , AlAlwan Bader , Alomar Fadhel A.
Published: June 2024

Introduction

Polypharmacy, the use of multiple medications, is a growing concern among middle-aged and older patients, posing potential risks and challenges in healthcare management.

Aim

This study aimed to identify the prevalence of polypharmacy and hyper-polypharmacy among populations of middle-aged vs. older patients and identify its associated common comorbidities and prescribed medications in Qatif Central Hospital (QCH), Saudi Arabia.

Methods

Patients aged 40 years or older who presented to an outpatient medical care clinic at QCH, Saudi Arabia, between 1 January and 31 December 2021 were included, and their comorbidities, prescribed medications, and recent clinical laboratory test results were collected. The Charlson comorbidity index (CCI) score was calculated to predict the risk of mortality. Logistic regression was used to compute the association between the prevalence of polypharmacy and patient characteristics. The results were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results

A total of 14,081 patients were included; 31% of the cohort comprised older patients, and 66% of the cohort was identified with polypharmacy. The majority of the polymedicated patients were presented to an internal medicine care unit (34%). The prevalence of polypharmacy was positively associated with CCI (OR = 3.4, 95% CI 3.3–3.6), having a disease related to the musculoskeletal system (MSD) (OR = 4.2, 95% CI 3.8–4.7), and alimentary tract and metabolism (ATM) (OR = 3.8, 95% CI 3.4–4.2). Conversely, the prevalence of polypharmacy was negatively associated with age (OR = 0.9, 95% CI 0.89–0.91) and patients with cardiovascular diseases (OR = 0.6, 95% CI 0.5–0.7).

Conclusion

Polypharmacy is still an ongoing concern. Patients, particularly those with diseases related to MSD or ATM, should be considered for reviewing prescriptions by pharmacists to reduce the risk of adverse drug reactions and future consequences of polypharmacy.
Enhancing signal-to-noise ratio in active laser imaging under cloud and fog conditions through combined matched filtering and neural network
Authors: Cui Chengshuai , Zhang Zijing , Wang Hongyang , Zhao Yuan
Published: June 2024

Active laser imaging utilizes time-of-flight and echo intensity measurements to generate distance and intensity images of targets. However, scattering caused by cloud and fog particles, leads to imaging quality deterioration. In this study, we introduce a novel approach for improving imaging clarity in these environments. We employed a matched filtering method that leverages the distinction between signal and noise in the time domain to preliminarily extract the signal from one-dimensional photon-counting echo data. We further denoised the data by utilizing the Long Short-Term Memory (LSTM) neural network in extracting features from extended time-series data. The proposed method displayed notable improvement in the signal-to-noise ratio (SNR), from 7.227 dB to 31.35 dB, following an analysis of experimental data collected under cloud and fog conditions. Furthermore, processing positively affected the quality of the distance image with an increase in the structural similarity (SSIM) index from 0.7883 to 0.9070. Additionally, the point-cloud images were successfully restored. These findings suggest that the integration of matched filtering and the LSTM algorithm effectively enhances beam imaging quality in the presence of cloud and fog scattering. This method has potential application in various fields, including navigation, remote sensing, and other areas susceptible to complex environmental conditions.
Pet attachment and prosocial attitude toward humans: the mediating role of empathy to animals
Authors: Faner Jhon Marc V. , Dalangin Ethel Ann R. , De Leon Lei Ann Trishia C. , Francisco Levi D. , Sahagun Yessamin O. , Acoba Evelyn F.
Published: June 2024

Attachment relationships are widely recognized as influential in increasing prosocial tendencies, with existing literature indicating that human attachment can increase empathetic processes, thereby potentially facilitating prosocial behavior. Given that pets frequently fulfill the criteria for attachment figures, this study investigates whether the observed associations among human attachment, empathy, and prosocial attitudes extend to human-animal interactions (HAI). This study examines the relationship between pet attachment, animal empathy, and prosocial attitudes toward humans. The study hypothesizes that animal empathy mediates the association between pet attachment and prosocial attitudes. A cross-sectional survey was administered to 343 Filipino participants, predominantly consisting of single female young adults with college education backgrounds. Participants completed a battery of assessments including the Contemporary Companion Animal Bonding Scale (CCABS), the Animal Empathy Scale (AES), and the Prosocialness Scale for Adults (PSA). Aligned with our hypothesis, our study reveals that animal empathy plays a significant mediating role in the relationship between pet attachment and attitudes toward humans. We found that stronger pet attachment correlates positively with heightened animal empathy, subsequently leading to elevated levels of prosocial attitudes. Our findings prompt discussions on implications for understanding human-animal relationships and suggest avenues for future research exploration.
The indirect impact of the technostress subfactors on the satisfaction and desire to work from home
Authors: Simon Adél Csenge , Buzás Barnabás , Rosta-Filep Orsolya , Faragó Klára , Pachner Orsolya Csilla , Kiss Orhidea Edith
Published: June 2024

Introduction

Organizational digitalization is a phenomenon that is becoming more widespread and holistic; that is responsible for more employees being affected by digital work and working from home. While introducing remote work offers numerous economic benefits for organizations, this transition must be aligned with employees' needs rather than in an authoritarian manner. Our research aimed to investigate how sub-factors of technostress, directly and indirectly, influence the satisfaction and desire to work from home.

Methods

We conducted a cross-sectional survey with a sample of 361 office workers with at least two years of experience who have spent some time working from home. We checked our hypotheses with a path model.

Results

Our research found that techno-insecurity and techno-complexity have a minimal direct influence on the desire to work from home. However, the desire to work from home significantly decreases through various mediation pathways via the status sub-factor (which can be seen as one of the latent benefits of remote work) and through satisfaction with working from home. Our model explains 33.7% of the variance in the desire to work from home.

Discussion

This suggests that leaders have a task of great significance: to decrease the technostress employees are exposed to and to draw the attention of researchers to the fact that technostress has more complex indirect effects than previously assumed.
Comparing and contrasting barriers in augmentative alternative communication use in nonspeaking autism and complex communication needs: multi-stakeholder perspectives
Authors: Yau Shu H. , Choo Kaylynn , Tan Jane , Monson Olivia , Bovell Stephanie
Published: June 2024

Augmentative alternative communication (AAC) devices or systems are often prescribed to minimally verbal or nonspeaking autistic individuals and other individuals with complex communication needs to facilitate communication or as an alternative to spoken language. AAC use can result in communication gains and improved quality of life for minimally verbal or nonspeaking individuals. Despite this, AAC abandonment is high, limiting societal participation of the individual on the autism spectrum with complex communication needs. Our study is a novel exploration of the barriers of AAC use from a multi-stakeholder perspective, and a qualitative analysis of similarities and differences between stakeholders. We conducted semi-structured interviews and focus groups with 30 parent-carers, educators and clinicians currently supporting AAC users in Western Australia and analysed the data using reflexive thematic analysis. Barriers from each stakeholder group were coded, resulting in 17 subthemes forming five main themes common to all stakeholders: Stakeholder Knowledge, Stakeholder Attitudes and Stigma, Resources, AAC User Engagement, and Device Fit. Contrasting perspectives included actual and perceived stigma associated with AAC use (parent-carers vs clinicians); different struggles with resources and knowledge (parent-carers vs clinicians and educators); and a lack of clinician communication in the processes that determined AAC-fit for school environments (educators only). Findings are discussed in the context of improving inter-stakeholder collaboration and capacity building in Australian health service and practice to better support minimally verbal or nonspeaking autistic individuals and individuals with complex communication needs. Suggestions are also offered for communication partner training.
Trends in injury-related mortality among residents of Jiangsu Province from 2012 to 2021: an age-period-cohort analysis
Authors: Du Wencong , Wang Rong , Fan Xikang , Wu Xun , Yang Jie , Zhou Jinyi , Yu Hao
Published: June 2024

Objective

We investigated the temporal trends and examined age-, period-, and cohort-specific effects of injury-related deaths among residents in Jiangsu to provide evidence for future injury prevention.

Methods

This study included 406,936 injury deaths from the Jiangsu provincial population death registration system. The average annual percent change (AAPC) in age-standardized mortality rates (ASMRs) was analyzed using joinpoint regression. Age-period-cohort models were generated to explore the effects of age, period, and birth cohort effects on mortality risk.

Results

ASMRs for all injuries (AAPC = −2.3%), road traffic accidents (AAPC = −5.3%), suicide (AAPC = −3.8%), and drowning (AAPC = −3.9%) showed a downward trend during 2012–2021(all p < 0.05), while unintentional falls showed an upward trend (AAPC = 5.1%, p < 0.05). From 2012 to 2021, the age-standardized mortality rates (ASMRs) for four primary types of injuries consistently exhibited higher among males compared to females, with rural regions displaying higher ASMRs than urban areas. Trends in ASMRs for road traffic accidents, drowning, and unintentional falls by sex and urban/rural areas were consistent with overall trends. Significant age, cohort, and period effects were identified in the trends of injury-related deaths for both sexes in Jiangsu. The age effect showed that the highest age effect for injury-related deaths was for the ages of 85 years and above, except for suicide, which was for the ages 80–84 years. Between 2012 and 2021, the period effect on road traffic accidents declined, while that on accidental falls increased. Initially, the period effect on suicide decreased but then rose, peaking in 2012 with a Relative Risk (RR) of 1.11 (95% CI: 1.04–1.19). Similarly, the period effect on drowning initially declined before rising, with the highest effect observed in 2013, at an RR of 1.12 (95% CI: 1.07–1.19). The highest cohort effects for road traffic accidents were observed in the 1957–1961 group, for accidental falls in the 1952–1956 group, and for both drowning and suicide in the 1927–1931 group.

Conclusion

The mortality rate of unintentional falls has been increasing. Older adults are at high risk for the four leading injuries. The improvements in mortality rates can be attributed to advancements in education, urbanization, and the promulgation and implementation of laws and policies.
Time-series representation learning via Time-Frequency Fusion Contrasting
Authors: Zhao Wenbo , Fan Ling
Published: June 2024

Time series is a typical data type in numerous domains; however, labeling large amounts of time series data can be costly and time-consuming. Learning effective representation from unlabeled time series data is a challenging task. Contrastive learning stands out as a promising method to acquire representations of unlabeled time series data. Therefore, we propose a self-supervised time-series representation learning framework via Time-Frequency Fusion Contrasting (TF-FC) to learn time-series representation from unlabeled data. Specifically, TF-FC combines time-domain augmentation with frequency-domain augmentation to generate the diverse samples. For time-domain augmentation, the raw time series data pass through the time-domain augmentation bank (such as jitter, scaling, permutation, and masking) and get time-domain augmentation data. For frequency-domain augmentation, first, the raw time series undergoes conversion into frequency domain data following Fast Fourier Transform (FFT) analysis. Then, the frequency data passes through the frequency-domain augmentation bank (such as low pass filter, remove frequency, add frequency, and phase shift) and gets frequency-domain augmentation data. The fusion method of time-domain augmentation data and frequency-domain augmentation data is kernel PCA, which is useful for extracting nonlinear features in high-dimensional spaces. By capturing both the time and frequency domains of the time series, the proposed approach is able to extract more informative features from the data, enhancing the model's capacity to distinguish between different time series. To verify the effectiveness of the TF-FC method, we conducted experiments on four time series domain datasets (i.e., SleepEEG, HAR, Gesture, and Epilepsy). Experimental results show that TF-FC significantly improves in recognition accuracy compared with other SOTA methods.
Diversity and compositional differences in the oral microbiome of oral squamous cell carcinoma patients and healthy controls: a scoping review
Authors: van Dijk M. C. , Petersen J. F. , Raber-Durlacher J. E. , Epstein J. B. , Laheij A. M. G. A.
Published: June 2024

Objectives

The human oral microbiome may play a role in the development of oral squamous cell carcinoma. The aim of this scoping review was to examine microbial diversity and differences in the composition of the oral microbiome between OSCC patients and healthy controls.

Methods

A literature search (in PubMed and Embase.com) was performed on January 9, 2023. The outcome variables used from the included studies of this review were alpha- and beta diversity and oral microbiome composition profiles for each taxonomic level (phylum-, class-, order-, genus- and species level).

Results

Thirteen out of 423 studies were included in this review compromising 1,677 subjects, of which 905 (54.0%) were OSCC patients and 772 (46.0%) were healthy controls. Most studies found a higher alpha diversity in the OSCC patient group and significantly different beta diversities between OSCC patient samples and healthy control samples. Studies reported more abundant Fusobacteria (on phylum level), Fusobacterium (on genus level), Fusobacterium nucleatum, Porphyromonas endodontalis and Prevotella intermedia (on species level) in OSCC patients. The healthy control group had more abundant Actinobacteria (on phylum level), Streptococcus and Veilonella (on genus level) and Veilonella parvula (on species level) according to most studies.

Conclusions

Our findings show differences in oral microbiome diversity and composition in OSCC patients. Clinical implications demand continuing study. Development of internationally accepted standard procedures for oral sample collection and oral microbiota analysis is needed for more conclusive and clinically relevant comparisons in future research.
Sustainable, resilient, regenerative? The potential of Melbourne’s peri-urban region
Authors: Butt Andrew
Published: June 2024

Peri-urban regions offer significant contributions to city regions as landscapes of food production, resources for urban consumption, as well as for biodiversity and nature conservation – a key part of a city region as a socio-ecological, not simply a socioeconomic, space. Consequently, these roles have long been recognized as crucial to objectives of urban sustainability. They are also sites of socio-ecological tensions that relate to urbanization, as well as to the risk or hazard profile of locations undergoing social change. Whether sustainability, or resilience, in socio-ecological systems is a sufficient goal is increasingly under question. Seeking regenerative city regions, and in particular peri-urban landscapes requires reconsiderations of the relationships between policy, and the practices of communities and the state. Particularly with regard to planning policy this suggests consideration of the city and peri-urban region as connected, but also recognizing the specific qualities and vulnerabilities of peri-urban regions. Using the case of Narrm-Melbourne, Australia where several decades of planning policy have sought outcomes that reflect sustainability objectives this paper concludes that the peri-urban region has a strong potential to offer possibilities for a transformation to a sustainable, and potentially regenerative city region, but that current policy approaches are inadequate as they increase the vulnerabilities of communities, and neglect the potential of planning for multifunctionality and socio-ecological objectives.
Structurally unjust: how lay beliefs about racism relate to responses to racial inequality in the criminal legal system
Authors: Rucker Julian Michael , Duker Ajua , Richeson Jennifer Anne
Published: June 2024

Racial inequality has been a persistent component of American society since its inception. The present research investigates how lay beliefs about the nature of racism—as primarily caused by prejudiced individuals or, rather, to structural factors (i.e., policies, institutional practices) that disadvantage members of marginalized racial groups—predict reactions to evidence of racial inequality in the criminal legal system (Studies 1–3). Specifically, the current research suggests that holding a more structural (vs. interpersonal) view of racism predicts a greater tendency to perceive racial inequality in criminal legal outcomes. Moreover, White Americans' lay beliefs regarding racism, coupled with their general degree of preference for societal hierarchy, predict support for policies that would impact disparities in the U.S. prison population. Together, this work suggests that an appreciation of structural racism plays an important role in how people perceive and respond to racial inequality.
Development, RSM-based modeling, and process optimization of an ultrasonic coating system for extending the storage life of fresh fruits
Authors: Mohammed Maged , Alqahtani Nashi K. , Ali Salim A.
Published: June 2024

Effective and innovative freshly produced preservation methods are paramount for ensuring safe and sustainable food. Edible coatings for fresh dates can provide an additional protective layer to enhance their shelf life and extend marketability. However, the optimum coating requires a high uniformity of coating layer on the fruit. The ultrasonic coating can achieve a more uniform and consistent coating on the fruit surface. Therefore, this study aimed to design, evaluate, and optimize the process parameters of an innovative ultrasonic coating system (UCS) to enhance the shelf life and quality of fresh date palm fruit utilizing gum Arabic as an edible coating. The response surface methodology (RSM) was conducted using Design-Expert software Version 13. The central composite design was employed to determine the influence of eight independent variables, namely, coating time, air flow rate, liquid height above the ultrasonic transducers, liquid temperature, edible gum Arabic concentration, drying time for coated fruit, drying temperature, and storage temperature on the responses which were fruit shelf life, ripe fruit percentage, color changes, and weight loss. The optimization was conducted to determine the optimal solutions for enhancing fruit shelf life and quality. The optimal optimization outcome with the desirability of 0.90 demonstrated that coating fresh date palm fruits with a gum Arabic concentration of 9.58% at an air flow rate of 1.95 m/s, a height of liquid above the ultrasonic transducer of 0.62 cm, a liquid temperature of 40°C, a drying time of 7.4 min, a drying temperature of 30°C, and a storage temperature of 5°C resulted in extending the shelf life of the stored fruits to 65 days with 3.47 ripening percentage, 7.39 color change, and 4.22% fruit weight loss. The validation experiment conducted at the same independent variable levels indicated that the fruit shelf life extended to 60.2 ± 0.5 days, accompanied by a ripening percentage of 3.4 ± 0.4%, a color change of 10.3 ± 0.9, and a fruit weight loss of 5.4 ± 0.9%. The solutions were validated through rigorous experiments on fresh date palm fruit at the Khalal stage. The findings showed a positive response for fruit shelf life with a slight decrease in the percentage of fruit ripe, color change, and weight loss.
Effects of Leading Edge Radius on Stall Characteristics of Rotor Airfoil
Authors: Jing Simeng , Zhao Guoqing , Gao Yuan , Zhao Qijun
Published: June 2024

The effects of leading edge radius on the static and dynamic stall characteristics of rotor airfoils are investigated. Initially, a parametric airfoil (PARFOIL) method is employed to generate four morphed airfoils with different leading edge radii based on a NACA 0012 airfoil. Subsequently, the Reynolds-averaged Navier–Stokes (RANS) method is employed to simulate the aerodynamic characteristics of static airfoils, while the improved delayed detached-eddy simulation (IDDES) method is employed for pitching airfoils. The effectiveness and accuracy of the computational fluid dynamics (CFD) methods are demonstrated through favorable agreement between the numerical and experimental results. Finally, both the static and dynamic aerodynamic characteristics are simulated and analyzed for the airfoils with varying leading edge radii. Comparative analyses indicate that at low Mach numbers, the high adverse pressure gradient near the leading edge is the primary cause of leading edge separation and stall. A larger leading edge radius helps to reduce the suction pressure peak and adverse pressure gradients, thus delaying the leading edge separation and stall of airfoil. At high Mach numbers, the leading edge separation and stall are mainly induced by the shock wave. Variations in leading edge radius have minimal impacts on the high adverse pressure gradient induced by the shock wave, thus making the stall characteristics of airfoils almost unaffected at high Mach numbers.
Nutritional Quality of Early-Generation Kernza Perennial Grain
Authors: Craine Evan B. , DeHaan Lee R.
Published: June 2024

Grain from improved varieties of the perennial grass Thinopyrum intermedium (Host) Barkworth & D.R. Dewey is marketed under the trade name Kernza (common name intermediate wheatgrass, IWG). While a growing body of evidence is available on the nutritional quality of Kernza, gaps exist for components such vitamins and minerals and protein quality. Therefore, we performed two studies on early-generation breeding program material, characterizing nutritional quality by quantifying macronutrients, sugars, dietary fiber, amino acid profiles, fat composition, vitamins, minerals, carotenoids, antioxidants, and antioxidant activity. The IWG studied frequently had concentrations significantly different from the reference values for whole wheat flour. For example, IWG had 50% higher protein, 129% higher dietary fiber, and 65% higher ash content than reference whole wheat flour. Calcium and selenium were 267% and 492% higher, respectively, in IWG than whole wheat flour. Riboflavin and folate were 43% and 447% higher, respectively, and niacin 74% lower in IWG versus whole wheat flour. We identified lysine as the limiting amino acid, although its concentration was 33% greater in IWG than in whole wheat flour. These results support potential benefits of Kernza for human nutrition. This work supports ongoing studies to further characterize and evaluate nutritional quality during the domestication and breeding process.
Lactic Acid Bacteria from Bombyx mori Frass: Probiotic Properties and Antagonistic Activities
Authors: Suraporn Siripuk , Cansee Sopa , Hupfauf Sebastian , Klammsteiner Thomas
Published: June 2024

Insect farming is gaining attention as a promising area for exploring probiotic bacteria, which can benefit both insect health and various industries. Silkworm farming is a key industry in Thailand; however, challenges such as disease susceptibility and optimising growth require innovative solutions for sustainable practices. Our study addresses this by assessing lactic acid bacteria (LAB) in native Thai silkworm faeces, which accumulate as natural by-products during the rearing process. We conducted biochemical tests, including those for catalase, haemolytic activity, bile salt tolerance, antimicrobial activity, antibiotic susceptibility, and cell surface hydrophobicity, along with taxonomic classification. Out of 102 isolates, eight potential probiotics were selected, with five showing strong probiotic traits like acid and bile salt tolerance and cell surface hydrophobicity, enhancing gut survivability. These isolates also displayed antagonistic activity against pathogens like Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, and Pseudomonas aeruginosa. Safety assessments confirmed their safety, with no haemolytic activity and sensitivity to antibiotics like chloramphenicol and amoxicillin. These LAB isolates (SP04, SP06, SP44, SP64, and SP67), identified as Enterococcus faecalis strain NBRC 100481, show promise as in vitro probiotics for silkworm rearing, calling for further in vivo evaluation.
Comprehensive Evaluation of Apple Germplasm Genetic Diversity on the Basis of 26 Phenotypic Traits
Authors: Tian Wen , Li Zichen , Wang Lin , Sun Simiao , Wang Dajiang , Wang Kun , Wang Guangyi , Liu Zhao , Lu Xiang , Feng Jianrong , Gao Yuan
Published: June 2024

We used 256 apple germplasm resources for a thorough examination of the genetic diversity associated with 26 phenotypic traits (i.e., genetic diversity analysis, cluster analysis, correlation analysis, principal component analysis, and membership function). The average coefficient of variation for 12 morphological traits was 66.39% (21.10–201.5%). The coefficient of variation was highest and lowest for the fruit arris and the width of the eye basin, respectively. Additionally, the diversity index ranged from 0.54 to 1.33. Moreover, the coefficient of variation for 14 numerical traits varied from 5.37% to 50%. The titratable acid content had the highest coefficient of variation, with a diversity index ranging from 2.01 to 2.08 (average of 2.045). A cluster analysis categorized 256 germplasms into four groups, among which Group I included germplasms with large fruits and the best comprehensive performance. Of the top 10 principal components revealed by the principal component analysis, principal component 1 was mainly related to fruit size and flavor. The top 10 germplasms were selected on the basis of comprehensive scores using the membership function method. Furthermore, a stepwise regression analysis identified 15 key traits for identifying apple germplasms, including the vegetative growth day, fruit weight, and the firmness of the fruit without skin. These results can serve as the foundation for future analyses of the phenotypic diversity of apple germplasms, while also providing a theoretical basis for screening, characterizing, and further improving excellent apple germplasms.