bluuebunny/crossref_metadata_2025 huggingface dataset:
Foundation for waterlogged bases with conical void design
Authors: Mukhamejanova Assel , Abdrakhmanova Kalamkas , Toleubayeva Shamshygaiyn , Kozhas Aigul
Published: February 2023

The article presents hollow foundations that play a multifunctional role: drainage to accelerate the process of consolidation of weak water-saturated cohesive foundation soils, drainage in case of obvious underflooding, anti-barrage in case of latent underflooding, as well as compensating for possible swelling or frost heaving of the clay soils. The adopted design solution makes it possible to transfer the load from the foundation to the soil foundation that includes loose cavity filling material through a more developed support area than a foundation with a flat footing. Unlike the solid foundation, the hollow foundation has a higher bearing capacity by 120 N more, and in the intervals of high loads (> 400 N) the settlement of the hollow foundation develops with an occasional lag from the settlement of the solid foundation. The use of hollow concrete foundations makes it possible to expand the area of application of prefabricated foundations, simplify their manufacture, increase their bearing capacity and ensure their strength and durability, while reducing the material intensity and cost of construction.
Improvement of growth, yield and quality of banana cv. Grand Naine by application of potassium humate
Authors: Maklad Taha
Published: February 2023

Precise choice of potassium (K) source and application method does matter for its cost-effectiveness. The effect of soil potassium fertilization either as sulfate or humate form with or without K2SO4 foliar sprays was studied on vegetative growth, yield and fruit quality of Grand Naine banana plants grown under clay loam soil conditions. The experiment included four treatments as follows: Control (800 g of K2SO4 as soil application), 250 g of K-humate as soil application, 800 g of K2SO4 as soil application + 2 % K2SO4 as foliar sprays and 250 g of K-humate soil application + 2 % K2SO4 as foliar sprays. Each treatment was replicated three times with three plants per each replicate and the randomized complete block design was arranged. Results indicated that potassium fertilization treatments showed a positive effect on vegetative growth parameters, N, P, K, chlorophyll a and b content in the leaves, also improved yield and fruit properties. In this respect, the humate form was more pronounced than the sulfate form. In addition, treatments included K2SO4 as foliar sprays were more effective than those without it. Therefore, the usage of 250 g of K-humate as soil application + 2 % K2SO4 as foliar sprays could be recommended to improve the growth, yield and quality of Grande Naine banana under these experimental conditions.
Cervical cancer risk levels among women aged 30-65 and factors affecting compliance with the national cervical cancer screening standards
Authors: Koca Bennur , Acikgoz Ayla
Published: February 2023

Screening programs for early detection of cervical cancer are extremely important for better prognosis and long-term survival. This study was conducted to determine cervical cancer (CC) risk levels among women aged between 30-65 and the factors affecting having an HPV/Pap smear test that complies with national CC screening standards. A total of 1407 women in the 30-65 age group participated in this cross-sectional study. No sample selection procedure was conducted, and 1407 women who voluntarily agreed to participate in the study were included in the study group. Data were collected between January 2019 and March 2020. The questionnaire used in the study consisted of questions about women's sociodemographic characteristics, lifestyles, CC early diagnosis and screening behaviors, and the CC risk calculation model. Pearson chi-square test, chi-square test for trend, and logistic regression analysis were used in the study. The statistical significance level was accepted as p< 0.05. In the study, 58.9% of the women reported that they had a test within one to three years, 67.5% of those who did not have the test stated they did not know that it was necessary, and 46.2% stated that they neglected it. The CC risk level of 83.6% of women was “below average”. The rate of having an HPV/PS test following the national CC screening standards was significantly higher in women who were in the 50-59 age group, smoked, had a childbirth experience, or did not regularly use a condom during sexual intercourse (p<0.05). As the calculated CC risk level increased, testing behaviors decreased statistically significantly (p<0.01). The time of the last screening test was more than five years in those with a calculated CC risk level of ≥average (p<0.01). The CC risk level of the women in the study was below average. There was a significant relationship between HPV/PS testing behavior and age, smoking, having a childbirth experience, and condom use.
Pregnancy-related carpal tunnel syndrome; non-invasive early diagnosis and postpartum evaluation
Authors: Ozturk Aslihan , Erpala Firat
Published: February 2023

The diagnosis of pregnancy-related carpal tunnel syndrome (PRCTS) was made with noninvasive methods and evaluated the effect of PRCTS on quality of life, its treatment and prognosis. Third-trimester pregnant women between the ages of 18-45 and diagnosed with PRCTS were included. For diagnosis; the presence of pain, positive motor and sensory tests, Carpal Tunnel Symptoms Scale-6 (CTS-6), and Boston Carpal Tunnel Questionnaire (BCTQ) were evaluated. The criteria used to determine improvement were the regression of complaints and symptoms based on a VAS score of 0 and a CTS-6 score of less than 5. According to these criteria, patients whose complaints regressed in the postpartum eighth week were called group A, whose complaints regressed in the postpartum sixth month were called group B, and women who still did not meet the criteria were called group C. The study included 102 wrists of 94 women. When the type of delivery, gestational age at birth, gravida, and parity were compared according to the continuity of complaints and symptoms, no differences were found. When the first trimester body mass index (BMI) measurements were compared between groups A and B, it was observed that group B had higher first trimester BMI values; this difference was statistically significant. The mean age was 29.2 years in group A, was 32.6 years in group B and the difference was significant. Conclusions: We recommend that pregnant women over 30 years old with a high BMI should be screened for PRCTS using non-invasive diagnostic tools, CTS-6, and VAS.
Therapeutic effects of transcranial direct current stimulation on ketamine-induced schizophrenia-like behaviors and oxidative stress
Authors: Akcay Guven
Published: February 2023

Schizophrenia is a serious neuropsychiatric disorder that affects 1% of the world's population. It plays an important role in psychiatric symptoms, including major depression and schizophrenia. However, it is also known that one of the main reasons underlying the pathogenesis of schizophrenia is oxidative stress. Transcranial direct current stimulation (tDCS) has recently been a promising method for modifying neuronal membrane stimulation, cognition, and behavioral function. Our aim in this study is to explore the effects of 0.5 mA anodal tDCS stimulation on schizophrenia-like behaviors and oxidative stress in a ketamine-induced schizophrenia model. 30 male Balb/C mice were divided into 3 groups as control, schizophrenia, and schizophrenia+tDCS. The schizophrenia model was created by administering 25mg/kg/day ketamine for 7 days. tDCS treatment was performed by giving 0.5 mA anodal tDCS stimulation for 7 days. On day 14 of the experiment, SCZ-like behaviors were assessed using a novel object recognition test (NOR), open field test (OF), and tail suspension test (TST), and also oxidative stress in hippocampus and prefrontal tissues was estimated. Results showed that locomotor activity, depressive and anxiety-like behaviors of the schizophrenia group increased significantly compared to the control group and decreased after tDCS stimulation (p<0.05). In addition, it was investigated that tDCS stimulation also significantly increased learning that decreased after schizophrenia (p<0.05). All together, it was observed that the total antioxidant capacity of the schizophrenia group decreased while the total oxidant capacity of the schizophrenia group rose in the prefrontal cortex and hippocampus tissues compared to the control group (p<0.05). Otherwise, 0.5 mA anodal tDCS stimulation increased the total antioxidant capacity of the schizophrenia+tDCS group compared to the schizophrenia group, while it decreased total oxidant capacity (p<0.05). Based on our results displayed that 0.5 mA anodal tDCS stimulation for 30 minutes for 7 days reduced schizophrenia-like behaviors and oxidative stress by modulation of N-methyl-D-aspartic acid (NMDA) receptors in the glutamatergic pathway in a ketamine-induced, NMDA antagonist, schizophrenia model.
Magnetic resonance imaging features varying by size in giant hemangioma of the liver
Authors: Ediz Suna , Gunduz Nesrin
Published: February 2023

Different definitions are used for giant liver hemangiomas. When liver hemangiomas are larger than 4 cm, they are called cavernous hemangiomas (CHs). 6cm or higher thresholds have also been suggested in the literature. Mastering the magnetic resonance imaging (MRI) features that change as the size of CHs increases can prevent misdiagnoses. The aim of the study was to compare MRI features of CHs between 4-6cm and >6cm. The contrast-enhanced abdominal MRIs in the hospital image archiving system was retrospectively examined in the last two years. A total of 52 patients (39 females, 13 males) with CHs were detected by screening. MRI features of 30 patients in Group 1 (between 4-6cm) and 22 patients in Group 2 (>6cm) were analyzed and the two groups were compared in terms of imaging features. The presence of a central cleft-like area was found to be more in Group 2 (54.5%) than in Group 1 (6.7%) (p<0.001). Internal hemorrhage was not detected in Group 1, but it was seen in 3 (13.6%) patients in group 2 (p=0.07). The multiloculation-like appearance was significantly higher in Group 2 (86.4%) than in Group 1 (23.3%) (p<0.001). Delayed diffuse enhancement was observed at a rate of 30% in Group 1 patients, while it was not seen at all in Group 2 (p=0.007). In Apparent diffusion coefficient (ADC) mapping, the incidence of the hypointense rim in the periphery of CH was significantly higher in Group 2 (90.9%) than in Group 1 (66.7%) (p=0.04). ADC value was higher in Group 1 (1.76±0.28) than Group 2 (1.55±0.24) (p=0.007).
Investigation of the frequency of left ventricular hypertrophy in hypertensive patients by the hospital anxiety and depression scale
Authors: Ayhan Selcuk , Abus Sabri , c Yasar , Kaya Hakan
Published: February 2023

The development of left ventricular hypertrophy (LVH) in patients with hypertension increases the frequency of ventricular arrhythmias and sudden death. It is known that psychiatric conditions such as anxiety and depression are associated with hypertension (HT) and other cardiovascular diseases. HT patients were assessed using the Hospital Anxiety and Depression Scale (HADS). Sociodemographic and laboratory data of the patients were recorded. LVH was seen in 34 of 103 patients, and LVH was not seen in 69 patients. The mean age was 47.8 years in the group with LVH and 49.5 in the group with non-LVH. According to the results of our study, there was no significant difference between the LVH group and the Non-LVH group in terms of age, gender, BMI, smoking, loneliness status, and EF. The most striking result of our study was that the HADS score was significantly higher in the group with LVH than in the group with Non-LVH (p<0.001). The glucose level was significantly higher in the group with LVH than in the group with non-LVH (p<0.001). Patients should be aware of adverse cardiac outcomes according to their anxiety level, and precautions should be taken while performing mental health interventions and treatments. In order to better explain the causes and pathophysiology that may lead to LVH in anxiety disorders and depression, more comprehensive and molecular-level investigations are required.
Randomized and comparative study analyzing efficacy and safety profile of sitagliptin in early diabetic nephropathy
Authors: Rajesh Keerthana , Asuvathi Rajesh , M Rajeshware
Published: February 2023

Background: Diabetes mellitus is the most common cause of chronic kidney disease. Microalbuminuria is an early sign of diabetic nephropathy. Angiotensin converting enzyme (ACE) inhibitors decrease albumin excretion and prevent its progression. Sitagliptin is a novel therapeutic agent for Type 2 diabetes mellitus. Hence, this study was carried out to investigate the effect of sitagliptin in albuminuria along with ACE inhibitors and its efficacy, and safety of glycemic profile in diabetic nephropathy.

Aims and Objectives: This study evaluated the efficacy of sitagliptin in retarding the progression of albuminuria, and assessing its safety of glycemic profile in patients with Type 2 diabetes with early stage of nephropathy.

Materials and Methods: In this randomized and open-label study, patients with diabetic nephropathy were randomized to two groups (n = 30 each). The control group received oral Anti Diabetic Drugs+ Tab. Enalapril 2.5 mg and the study group received antidiabetic drug + Tab. Enalapril 2.5 mg+ Tab. Sitagliptin 100 mg. The patients were evaluated at the end of 24 weeks.

Results: Urinary albumin creatinine ratio decreased from 302.10 to 143.83 at 24 weeks in the sitagliptin-treated group (P = 0.001) and in the control group UCAR value reduced from 324.10 to 290.93 mg/g. Statistically significant reductions in hemoglobin, fasting blood sugar, post-prandial blood sugar, and systolic blood pressure were observed in the sitagliptin-treated group. Adverse effects reactions were less in the study group (10%) than in the control group (26%).

Conclusion: Sitagliptin significantly reduced albuminuria and improved glycemic control and was well tolerated in patients with early-stage diabetic nephropathy.
Significance of serum levels of magnesium, phosphorus, and calcium in hypertensive patients
Authors: Solanki Viral , Parikh Chetan , Pandya Chirag
Published: February 2023

Background: Hypertension also known as high blood pressure is one of the most common complex and public health problems which become more prevalent in developed and developing countries. Epidemiological studies have found links between high blood pressure and age, sex, race, geographic location, local industrialization level, lifestyle, nutrition, and work. Macro and microelements are known to play a major role in various enzyme reactions directly related to the regulation of blood pressure and indirectly related to generation of oxidative metabolic energy and alterations in blood lipid levels. Disturbances in these elements composition may therefore play a major role in the development and management of essential hypertension. The changes in plasma magnesium, calcium, and phosphorus level in hypertensive patients should therefore be actively investigated. The findings of this study may help to understand the effects of elements in the regulation of blood pressure.

Aims and Objectives: The aims of this study were to measure the levels of trace elements (Serum magnesium, phosphorus, and calcium) in patients of hypertension.

Materials and Methods: Serum magnesium, phosphorus, and calcium were estimated in 50 hypertensive patients and 50 age-and sex-matched apparently healthy well-nourished controls by colorimetric method using Erba XL 640 fully autoanalyzer.

Results: Mean serum magnesium, serum phosphorus, and serum calcium were significantly reduced in hypertensive patients than control group.

Conclusion: Hypertension is asymptomatic condition, whereby the patient’s blood pressure measurement is greater than 140/90 mmHg1. The causes of high blood pressure vary. It may be due to smoking of cigarettes, alcoholism, and narrowing of arteries. Diet definitely plays a crucial role in the development of hypertension along with stress. The relationship between trace elements and cardiovascular diseases, including high blood pressure, has been the subject of many investigations over the past 40–50 years. It is believed that mineral imbalance may significantly contribute to the development and course of hypertension. Mean serum magnesium, mean serum phosphorus, and mean serum calcium were significantly reduced, while serum copper was significantly higher in hypertensive patient than control group.
A study on the safety and tolerability of antiretroviral drugs prescribed in ART center of a rural-based tertiary care hospital
Authors: Paul Devlina , Pal Ayan , Mandal Sonai
Published: February 2023

Background: Human immunodeficiency virus (HIV) is a serious health problem worldwide. The mainstay treatment of HIV infected individuals is antiretroviral therapy (ART). Although ART is effective, it has its drawbacks as it is causes various adverse drug reactions (ADRs) which negatively affects patient compliance resulting in treatment failure. Various studies have been conducted in western population to study the adverse effects of ART, but such study in Eastern India is scanty. This study was conducted to fill the void and to help optimize treatment in this area.

Aim and Objectives: The aim of the study was to find the incidence and type of ADRs among patients on antiretroviral drugs and to evaluate the severity assessment of the ADRs caused by them.

Materials and Methods: Pre-structured case record form was used to collect information regarding demography, disease, treatment, etc., of 188 patients who came to the ART center after taking consent. ADRs were noted on the basis of patient complaints and changes diagnosed by the physician (if any) during routine visit. Descriptive statistical analysis was performed and inference drawn.

Results: Most of the subjects followed Tenofovir-Lamivudine-Efavirenz regimen of whom 89% experienced at least one ADR, central nervous system (CNS) being the most affected. Followed by Zidovudine-Lamivudine-Nevirapine regimen of whom 96% presented with at least one ADR where gastrointestinal (GI) side effects were maximum. Common CNS side-effects were dizziness followed by insomnia. Common GI side effects was anorexia followed by nausea and vomiting. Most of them were mild in severity assessment scale.

Conclusions: The study shows the ART regimens used by HIV patients and assess the ADRs caused by them. It helped to obtain information regarding demographic factors and disease pattern in this region. Further and more elaborate studies are needed to have proper insight and practical gains in this regard.
The influence of color on taste perception
Authors: Nanjundappa Nalina , B Umadevi , Jayasimha Ramya , K Thennarasu
Published: February 2023

Background: Taste perception is a highly subjective process that involves the other special senses as well. The visual and olfactory signals play an important role in perception of taste. We use visual cues from color to identify and judge the quality and taste of what we eat. Color has a major impact on taste perception which seems to influence our taste buds more than olfactory sense.

Aim and Objective: The objective of present study was to assess the influence of color of sucrose solution on its taste perception.

Materials and Methods: About 53 female subjects in the age group of 17–20 years were asked to taste a fixed quantity of the sucrose solution of six different colors of same sucrose concentration. The subjects were asked to rate them according to sweetness scale of 1–10. The mean and standard deviation of the scores was obtained.

Results: The purple colored solution was rated as highest sweetness (6.09 ± 2.09) followed by blue (5.9 ± 1.9), green (5.62 ± 1.97), red (5.11 ± 1.63), and yellow (4.20 ± 1.75).

Conclusion: The clear sucrose solution was rated the same as the purple solution. The colors like purple and blue were perceived sweeter compared to red and yellow indicating that color of the solution does influence the perception of its taste.
Repositioning of FDA-approved drugs for the treatment of methicillin-resistant Staphylococcus aureus infection: Structure-based virtual screening and in vitro assay
Authors: Chika Aminu , Otalike Edith , Lawal Salihu , Umar Muhammad , Usman Abdulkadir , Amali Abubakar , Yahaya Mohammed , Adamu Adamu
Published: February 2023

Background: Computer-aided repositioning of approved drugs is an increasingly popular strategy for the discovery of effective therapies. The potency of the newly repositioned drugs can be optimized using them as a component of an effective drug combination, thereby achieving the desired therapeutic effect at a lower and more tolerable drug concentration.

Aim and Objectives: The aim of the study was to perform structure-based virtual screening and repurposing of FDA-approved drugs for the treatment of methicillin resistance by Staphylococcus aureus (SA) and perform an in vitro validation of the prediction.

Materials and Methods: Following ethical clearance at the Department of Pharmacology and Therapeutics, College of Health Sciences, Usmanu Danfodiyo University Sokoto, molecular docking was performed against 5 validated protein targets involved in the development of methicillin resistance by SA and an in vitro validation of the prediction was done using 3 of the top-ranking drug candidates against methicillin-resistant vancomycin-susceptible strain of the pathogen (ATCC 43300).

Results: Desmopressin and docetaxel, two of the 20 top-ranking repurposed drugs discovered through virtual screening, enhanced the inhibitory effect of oxacillin against the ATCC 43300 SA strain in a ratio-dependent manner, although each of the two drugs singly was only weakly effective against the bacterial strain. The standard drug, vancomycin (also among the top-scoring candidates), alone, was effective against ATCC 43300 strain and in combination with oxacillin, the two drugs produced a ratio-dependent synergistic effect against the bacterial strain.

Conclusion: These findings suggest that oxacillin-based combinations with desmopressin, docetaxel, and the standard drug vancomycin, three of the 20 top-ranking drugs, at optimum ratios, may be beneficial in reversing the resistance of the ATCC 43300 SA strain to oxacillin, thus supporting the prediction of the molecular docking results.
An unusual case of restricted mouth opening in a young female
Authors: Gupta Akhil , Singh Somil , Chatterjee Sumeet , Chaubey Manaswi , Chakravarty Jaya , Rai Madhukar
Published: February 2023

Ankylosing spondylitis is a debilitating disease afflicting the joints. This disease is a major cause of functional impairment and disability in younger population with the mean age of onset around 26 years. The disease is characterized by chronic back pain and limited spinal mobility due to slowly occurring inflammation and later ankylosis of joints. Temporomandibular joint (TMJ) involvement is one such presentation of this disease with the incidence reported 4–35% among different case series. We describe a case of severe ankylosing spondylitis with TMJ involvement in a 27-year-old female patient.
Teaching faculty experiences on CBME curriculum in pharmacology – A cross-sectional questionnaire-based study
Authors: Dasaraju Rajesh , Bapugouda Patil , V Advaitha , Mark Andrew
Published: February 2023

Background: Many studies were conducted in India among the teaching faculties to understand the challenges before the implementation of new competency-based medical education (CBME) curriculum. Studies assessing the experiences and the challenges faced after its implementation are limited.

Aim and Objectives: The aim of this study was to assess the experiences and the challenges faced by the teaching faculties in different medical colleges across India while implementing the new CBME curriculum in pharmacology for the MBBS batch 2019–20 students.

Materials and Methods: A 19 item pre-validated questionnaire was shared to faculties through Google Forms with most of the questions having three options for answers, namely, “Agree,” “Disagree,” and “Not sure.” The time-period provided for answering the questions was 2 weeks. The data were analyzed using Microsoft Excel sheet using descriptive statistics.

Results: Majority of the faculties 56 (61.5%) do not agree with national medical commission in terms of number of teaching faculty and infrastructure to implement the CBME curriculum in pharmacology. About 56 (61.5%) of the faculties felt that the number of teaching hours recommended in the CBME curriculum for pharmacology are inadequate to cover all the competencies. Seventy-eight (85.7%) felt that the implementation of CBME curriculum for the 2019–20 batch MBBS students was impacted by COVID-19 pandemic.

Conclusion: Although faculty development programs played a crucial role in sensitizing faculties to implement CBME curriculum, subject specific problems do persist and the faculties need to motivate themselves to suggest ways to resolve them.
Re-feeding syndrome in children treated for severe acute malnutrition
Authors: Farhat Anila , Anwar Hamayun , Zeb Rabia , Qasim Muhammad
Published: February 2023

Objective: To determine the prevalence of re-feeding syndrome in children treated for severe acute malnutrition (SAM).
Methodology: This cross-sectional study was performed at Department of Pediatrics, King Abdullah Teaching Hospital, Mansehra, Pakistan from October 2020 to April 2021. A total of 186 children of either gender aged 1-5 years and admitted with SAM were included. Children with SAM were given F75-proxy every two hours for 2 days and then were fed with a locally made formula aimed to replace F-100 (F100-proxy), 6 times a day for a further duration of 2 days. After completing three days at the hospital, blood was drawn for measurements of blood and serum levels of phosphate, potassium, calcium and magnesium.
Results: In a total of 186 children with SAM, the mean age was 3±1.21 years while 100 (53.8%) children were aged between 1-3 years. There were 146 (78.5%) boys and 40 (21.5%) girls representing a male to female ratio of 3.5:1. Re-feeding syndrome was noted among 25 (13.4%) children.
Conclusion: Children with SAM were found to have high prevalence of re-feeding syndrome. Early recognition with appropriate treatment can be the key to a successful outcome in these children.
The Public's trends toward Kidney Donation
Authors: AbdElbagy Ahmed , Alkarani Ahmed
Published: February 2023

Objective: To explore the perception of Saudi society about living kidney donation and to identify the trends towards the donation of a kidney.
Methodology: This Quantitative cross-sessional community-based survey was carried-out from January to February 2020 among the Saudi population and included both natives and residents. We used convenience sampling technique. Perception about living kidney donation questionnaire was developed which included questions about knowledge regarding living kidney donation.
Results: Out of 1295 participants, 567 (43.8%) were males and 728 (56.2%) females. The overall mean score of the public`s perception about living kidney donation was moderate (mean=5.90±1.18). There was a statistical difference (F=3.44, p<0.05) between age groups toward perception regarding living kidney donation, as older and female patients have a better perception of kidney donation than young adults and men. The trends of the Saudi community about kidney donation were moderate; most participants agreed to donate a kidney for humanitarian and religious purposes. Participants were aware that living kidney donation improves the quality of life of the recipient.
Conclusion: Greater awareness about the center responsible for the organ transplantation can help willing donors to consent to future donation.
Relationship between vitamin D level and ovarian reserve markers in infertile women in Diyala province, Iraq
Authors: Alobaidy Enas , Saadi Raaked , Mansoor Shaymaa
Published: February 2023

Objective: To investigate the relationship between vitamin D and antral follicles (AFC) and anti-Mullerian hormone (AMH) .
Methodology: This cross-sectional study was conducted on infertile women. Patients had to be married, between the ages of 18 and 40, without a history of chronic illnesses, abstain from drug use, not have any specific gynecological diseases, as determined by the gynecologist who oversaw the project, and have an AFC count of less than 10 in sonography between less than 10 in sonography during early follicular period. Additionally, their AMH levels were lower.
Results: The study included 99 females with mean age of 29±6 years. Majority were over 21; 46.9% had college degrees, 53.1% were housewives, 83.7% were nonsmoking. Overweight women were 48.48% and obese were 3.13%. AFC and AMH significantly rose with vitamin D supplementation. Also, mean vitamin D levels fluctuated following supplementation.
Conclusion: Vitamin D has a promising influence on AMH expression. Vitamin D boosts AMH levels with increase in the number of antral follicles or ovarian reserve.
Helicobacter pylori and eradication response in Jordanian children; A cross-sectional longitudinal observational study
Authors: Burayzat Salma , Tamimi Mohammad , Barqawi Mohammad , Massadi Mustafa , bi Manar
Published: February 2023

Objective: To investigate the modalities of H. pylori diagnosis and management in Jordan and to elaborate on the feasibility of following international guidelines in diagnosing and managing H. pylori in children in our region.
Methodology: This is a case series of children with upper gastrointestinal symptoms. Gastric and duodenal biopsies were collected when pre-endoscopic or intra-endoscopic findings suggested H-Pylori gastric infection.
Results: The study included 116 children and adolescents, 52 (45%) were male and 64 (55.2%) females. Factors associated with failure of first eradication therapy; abdominal pain as a presenting symptom was significantly associated with the need for a second course of eradication. (p=0.037). Also, weight loss was significantly associated with the need for a second eradication therapy (p=0.028).
Conclusion: Presenting symptoms and consequences of H pylori acquisition can be a serious pathological issue. Therefore, diagnostics and treatment of the infection, as well as proper documentation of the eradication success, can be beneficial.
FEATURES OF THE FORMATION OF ZOOTONYMS OF THE SHET DISTRICT
Authors:   NAO «L.N. Gumilyov Eurasian National University», Yeginbayeva A.Ye. , Saparov K.T. ,   NAO «L.N. Gumilyov Eurasian National University»
Published: February 2023

The article considers the degree of reflection of the animal world in the toponyms of the Shet district of the Karaganda region. Patterns of spatial distribution of zoonyms, areas, and connections with the natural environment are revealed, which provide extensive information about changes in natural conditions and landscapes. The toponymic activity of animal names and their classification are grouped, and a map of the territory's zoonyms is compiled on the basis of actual data. It was found that some extinct animals (bear, antelope, deer, kulan, wild boar, etc.) lived in this territory, and the prerequisites for restoration were created.
WATER LEVEL VARIATIONS ON THE BALKASH LAKE IN THE MODERN PERIOD
Authors:   RSE «Kazhydromet», Ivkina N.I.
Published: February 2023

The article considers the nature of long-term and storm surge fluctuations in the level on the Balkash Lake. Statistics are presented and their seasonal distribution in different parts of the lake is described. It is noted that a change in the level entails a change in the morphometric characteristics of the lake; there is a tendency to reduce the area and, accordingly, the water volume of lake. The most vulnerable is the southern coast, which is a low-lying accumulative sandy plain. With wind surges, the coast is flooded in a strip from several hundred meters to several kilometers. Even fluctuations in the lake level (20...30 cm) lead here to significant displacements of the coastline. Surge phenomena in this area are the main factor in the for-mation of the relief. The amplitude of surge fluctuations of the Balkash Lake level signifi-cantly exceeds the annual amplitude of changes in the filling of the lake. The highest ampli-tude of surge oscillations is observed in Western Balkhash and at the end sections of the lake.
Focus, Time Management and Personal Energy of Students during Online Education
Authors: Grah Barbara , Penger Sandra
Published: February 2023

Focus and personal energy during study and work are vital in all learning outputs, especially in the covid-19 time that addresses the importance of self-focused behaviour in online learning environments. In this paper, we present a method of gaining insight into previous knowledge of students’ approaches to focusing and managing personal energy during covid-19 online studying environment to overcome stress. ”Manage your energy, not your time” cites a Harvard Business Review study (Schwartz & McCarthy, 2016), explaining that time management is a waste of time; therefore, we should manage our energy instead. Leaders should focus on managing personal energy and surviving in the workplace to manage stress and achieve a balanced career and private life in the long run. Management course students at the School of Economics and Business, University of Ljubljana, can be perceived as future leaders; we collected their opinions. We used content analysis to estimate how stress affects them and how they manage the consequences of stress, particularly procrastination. The problem with procrastination is that our brains are programmed to procrastinate, especially when it comes to new, unknown tasks. Therefore, our mind responds to postponing the task as fear arises with an unknown task. Results are presented, and key identified themes offer implications for managing physical, emotional, and mental energy. Students perform different cardiovascular sports activities to reduce stress and successfully overcome studying goals in the covid-19 environment.
A Living Lab Approach towards Promoting Innovation
Authors: Fortiş Alexandra Emilia , Petcu Alexandra
Published: February 2023

The transformation projects developed in the context of digital education, sustainable development research and social innovation, and social entrepreneurship have turned the West University of Timişoara (WUT) into an active contributor to the Smart Specialization Strategy at local, regional, and national levels, from its previous status of a passive receiver of policy and R&D strategies. By exploiting open innovation tools integrated into entrepreneurship and aimed at relevant community research, WUT is currently actively involved in the incubation and/or acceleration of more than 200 start-ups, meant to enhance research relevance to actively promote higher technology readiness levels (TRLs) and social acceptance of research results. Building on top of three priority pillars - Digital, Green, and Well-Being, WUT has reconsidered its open innovation strategy and action plan to benefit the community, using a multistakeholder approach. In this context, the Digital & Green Living Lab, with cross-cutting priorities such as entrepreneurship and Culture and Creative Industries, focuses on meaningful transformation projects that contribute to enhanced community well-being. In this direction, important contributions were already achieved toward the digital transformation of educational programs and administrative sectors. Through its sustainable development vision, WUT acts on functional teams working in circular economy consortia, renewable energies, and environmental research.
The Private Dining Restaurant: The Ideal Restaurant of the Future due to Covid-19?
Authors: Slivar Iva
Published: February 2023

This paper presents a model of a dislocated restaurant created based on dislocated hotels in Italy. This paper aims to provide an innovative solution for new initiatives in the food and beverage industry experiencing great losses due to the Covid 19 epidemic. The study uses an existing hotel model and adopts it in restaurants, and it uses analyses and synthesis for developing and defining new concepts. The private dining restaurant model represents a hybrid modification between dislocated hotels and classic à la carte restaurants and is more customized to the new normal. Depending on space constraints, a private dining restaurant can be built as a brand new restaurant or use the many empty spaces in the centre of many cities for this purpose, thus encouraging urban regeneration. Although, given its characteristics, this restaurant model is easier to apply from the beginning as such (as dislocated) rather than applying to existing buildings.
Sustainable Local Development Potential of the Elaphites, Croatia
Authors: Pisarović Anamarija , Tolić Iva , Tišma Sanja
Published: February 2023

The Elaphites comprise the archipelago of 13 islands, among them eight larger and five smaller stretching northwest of Dubrovnik in the Adriatic sea. The islands are covered with characteristic Mediterranean evergreen vegetation and attract large numbers of tourists during the summer due to their beaches and pristine nature. Only the three main islands are permanently inhabited, supporting a modest tourist industry. The diffuse hotel model („Albergo Diffuso“) is defined as creating visitor accommodation by reusing and restructuring existing houses, which must be located within an inhabited town center and therefore has multifold economic, social and environmental benefits for local communities. The core of the scattered hotel concept envisages its interaction with small village communities. The paper analyzes the socio-economic and environmental characteristics of this innovative approach to enhancing tourism activities and restoring the valuable cultural, natural, and historical heritage of the Elaphites.
The Integration of Digital Technologies in the European Union based on the DESI Index
Authors: Bittner Beáta , Kovács Tünde , Nábrádi András
Published: February 2023

Since the 2000s, the European Commission has been paying particular attention to the digital development of the European economy and society. Since 2014, the Digital Economy and Society Index (DESI) has been one of the key tools for monitoring and measuring. In 2021, the DESI index's core indicators were aligned with the objectives of the 2030 Digital Agenda, which has four dimensions: human capital, connectivity, integration of digital technology, and digital public services. We sought to determine whether convergence between the Member States could be detected using the third dimension of DESI's annual database. The σ-convergence analysis was used to estimate the reduction over time of the differences in digital technology integration between the Member States, while the β-convergence analysis was used to estimate the rate of catching up with the initial level of development. The σ- and β-convergence were not confirmed. We examined the individual indicators (11) of the integration of digital technology to identify critical areas that need to be addressed in the future to ensure that digital inclusion is as widespread as possible. Our analysis focused on the Member States that joined the EU during the Eastern European enlargements. The performance of all individual indicators is typically below the EU average, and, as the β-convergence analysis shows, the average catching-up rate is not encouraging.
A FUNCTIONALLY ACTIVE ECONOMICAL FLEXIBLE FINGER PROSTHESIS –A PROTOTYPE
Authors:   Dept. of Prosthodontics, Royal dental college, Iron Hills, Chalissery, Anil V Koruthu , Sowmya Balakrishnan , Rohit Raghavan , Shajahan P A
Published: February 2023

Amputation is the complete removal of an injured or deformed body part. It usually occurs during a traumatic injury or due to surgical amputation. The rehabilitation of an amputated finger depends on the amount of injury, amount of tissue and bone involved, location of the residual finger, and the aesthetics and functional needs of the patient. Most finger prosthesis is designed for an aesthetic purpose that helps the patient to pass unnoticed. A good prosthesis should provide a life-like appearance to duplicate the missing structures which should meet the aesthetics and functional requirement of the patient. This article describes the steps in the rehabilitation of an amputated finger and the working principles and design of the flexible finger prototype.
CAD/CAM CERAMIC MATERIALS FOR INDIRECT RESTORATIONS IN DENTISTRY—A REVIEW
Authors:   DEPARTMENT OF PROSTHODONTICS AND CROWN & BRIDGE,MALABAR DENTAL COLLEGE & RESEARCH CENTRE, PUNYA KRISHNAN B , BHASKARAN SAPNA , MERRY C PAUL MEENU , K MENON SUJITH , VENUGOPALAN DEEPTHI
Published: February 2023

The aim of this review article is to present various ceramic materials currently utilized in the field of CAD/CAM. Due to high aesthetic and functional demands of indirect restorations research on dental materials is increasing. Comparing the materials will take into account their mechanical properties, their clinical usage, their advantages and disadvantages.
Determinant Factors of Child Development in Various Ecosystem Zones in Papua
Authors: Manongga Stefanus P. , Litik Sherlie
Published: February 2023

Background: The negative impact of malnutrition is generally associated with impaired motor development, behavioural and cognitive development which results in decreased learning achievement and social skills.
Aim: The purpose of this study was to examine the situation of child development and to assess the role of various factors related to the development of children under five years of age in various ecosystem zones in Papua Province.
Method: The research was carried out in four districts in Papua representing three ecosystem zones, namely the mainland coast, the middle plains and the mountains. Data was collected through structured interviews, observations and field measurements. Analysis of the differences in variables between ecosystem zones used the smallest significant difference test and the Kruskal Wallis test. Meanwhile, the analysis of the impact of malnutrition on children's development used Structural Equation Modelling-Regression with a partial least square approach using the SmartPLS version 3.2.9 application.
Findings: The prevalence of Papuan children suffering from developmental delays reached 77.7%, especially in language development, fine motor adaptive, and personal social. An increase in the degree of malnutrition in the form of stunting suppresses the development of children to be low, while an increase in the degree of sickness in children has the potential to worsen the degree of malnutrition by suppressing the nutritional intake of children to be low.
A Study on Impact of Microfinance Institutions on Socio Economic Development of Saurashtran Women
Authors: Mehta Hiren Prakashbhai
Published: February 2023

Background: Microfinance in the global context is commonly referred to programmes meant for providing credit for self-employment and other financial and business services to poor persons. It is as same as extension of small loans to very poor for self-employment projects that generate income, allowing them to care for themselves and their families.
Aim: The objective of the study is to analyze the present status of management of micro finance in Saurashtra and it is relation to impact of micro finance among women SHGs in the study area.
Method: In the present study, both exploratory research and descriptive research have been used in accomplishing the objectives of the study. The researcher visited the various blocks on different dates and collected data from different self help groups. To analyze the primary data statistical tools such as Descriptive Analysis, Chi-square test, ANOVA, Garret ranking technique, Discriminate Function Analysis, Friedman Test Factor Analysis, Kendall's coefficient of concordance test, Kruskal-Wallis test, Neural network and Structural Equation Modeling have been used.
Findings: The study conclude that a ailment of Microfinance loan from microfinance institutions is helpful in empowering women economically, socio-culturally and politically. The study also found that the beneficiaries have reasonable employment, increase in income and participation in household financial decision-making as compared to non-beneficiaries.
Raptor Pordiosero y La Dama Pastora" en una versión campurriana (Cantabria).
Authors: Fraile Gil José Manuel
Published: February 2023

En la Baja Edad Media los poemas épicos y caballerescos toman nueva forma en la Península Ibérica: la del romance en castellano. El Romancero tiene su correspondencia directa en la balada románica, nacida en los territorios donde imperó el latín, y ambas formas se inscriben dentro de un género mucho más amplio que podríamos denominar como balada occidental, que compartió temas y argumentos por encima de las barreras lingüísticas. Por caminos diferentes –el catalán octosilábico y el cantábrico en versos de seis sílabas- penetró en España la balada que titulamos La dama pastora, que a veces unió su argumento en el área Noroeste a otra balada que conocemos por El raptor pordiosero. Este maridaje alcanzó su forma más perfecta en el área de Cantabria, donde hasta hoy hemos podido recoger bellísimas versiones como la que ahora analizamos.
«Unión de voluntades» y «Ajuste de intereses»: el matrimonio en el teatro sentimental del siglo XVIII
Authors: García Garrosa María Jesús
Published: February 2023

El artículo analiza el tema del matrimonio en el teatro sentimental español desde la perspectiva de la situación legal vigente y los cambios en las mentalidades y las prácticas sociales de la España de finales del siglo XVIII. Las obras estudiadas sugieren que la revolución sentimental originada por las nuevas corrientes de pensamiento no supuso la implantación de un ideal matrimonial asentado únicamente en el amor y en la libre elección de los contrayentes. La tesis de este trabajo, a la luz de los textos analizados, es que son los hijos los que plantean un modelo de matrimonio que no sólo toma en consideración los aspectos afectivos, sino también las implicaciones materiales de la unión conyugal, y que los jóvenes son los primeros en defender los valores tradicionalmente asociados al matrimonio por interés decidido por padres o tutores: el honor, el estatus o la riqueza, los que garantizan el orden social establecido. Se difunde así desde los escenarios un modelo de matrimonio basado en el amor razonable, en el que coinciden el afecto y la libre voluntad de los esposos con los intereses de las familias y del conjunto de la sociedad.
aspecto de la estética de la ironía: el arte de la cita en Leopoldo Alas «Clarín»
Authors: Fillière Carole
Published: February 2023

La ironía, considerada como estructura literaria global y no como mero procedimiento retórico, es un principio estético que afirma la subjetividad del autor y la construcción a la vez referencial y auto-referencial del texto literario. Este artículo enfoca la estética irónica de Leopoldo Alas Clarín a partir de su práctica de la cita. Verdadero arte de la relación, el estilo referencial y contrapuntista de Clarín reposa en un concepto íntimo de la cita textual como contacto intelectual y casi físico con un pensamiento, con un estilo y con un autor. La transtextualidad de la obra clariniana se nutre de todas las caras de la personalidad de su autor: el lector curioso, el crítico comparatista minucioso y el escritor observador de la realidad lingüística de su siglo. El análisis del caso paradigmático del uso del epígrafe en los cuentos revela cinco funciones principales de la cita en su obra: la construcción de la criatura literaria, la crítica y la estructura irónicas, el homenaje, el juego representativo y el germen de la re-escritura. El estilo referencial de Clarín participa de una estética irónica que fragmenta y recompone lo real en una perspectiva combinatoria que elabora un collage literario, plasmación textual de la libertad demiúrgica del autor.