bluuebunny/crossref_metadata_2025 huggingface dataset:
The organizational basis of the construction of the Soviet militia and the problems of their implementation in the Far East (October 1917 ‒ the beginning of the 1920s)
Authors: Ornatskaya Тatyana А.
Published: October 2019

Introduction. Currently, the centenary of the Russian revolution is widely celebrated ‒ an important milestone providing an opportunity to draw a line and analyze the events of a century ago. Together there are centuries-old anniversaries and other state structures formed in Soviet Russia. Materials and Methods. The end of the XX century was marked by access of a wide range of researchers to departmental archival materials. Expanding the availability of archival documents allows to critically assessing the formation of the Soviet militia. The author, using a regional approach, reveals little-known pages of the first far Eastern militia. Results. The purpose of this study is to cover the first period, i.e. before the beginning of the Civil war in the region, the activities of Soviet militia officers the article highlights the difficulties of the organizational construction of the Soviet militia in the Far East. The author, noting the remoteness of the region, the small number of the party stratum, rampant banditry that did not allow implementing the principles of the Soviet construction of the militia, defined by the leadership of the country, highlights the process of formation of the Soviet militia apparatus. Discussion and Conclusions. In conclusion, it is concluded that the fall of Soviet power in the Far East predetermined the transition of party leaders to an illegal situation, and, consequently, the temporary suspension of the activities of the Soviet militia.
International Study of Teacher Professional Identity
Authors: Berberyan Asya S. , Bogdanova Tatyana V. , Silchenkova Svetlana V. , Ermolaeva Elena B. , Vardanyan Nune T.
Published: October 2019

Introduction. The article is devoted to the international research project “Professional Identity of a Modern Teacher” (2013–2018). Formed professional identity is the key to self-realization and professional and personal development. As well as a developed and formed professional identity ensures successful professional activity, which is very important for the development of society. The purpose of the article is to reveal the content of the professional identity of the modern teacher. Materials and Methods. The main stages and empirical base of research are presented. Based on the analysis of the results of the survey according to the method “Professional Identity of a Higher School Teacher” and taking into account the specifics of the work of a school teacher, in 2017. The structural model of the teacher’s PI content was clarified, the content of the structural components of the model was adjusted, and the teacher’s Professional Identity methodology was created (authors A. Shpona, M. Widner, E. Ermolaeva, T. Bogdanova, S. Silchenkova) Statistical methods were used to analyze the data obtained: a comparison of the groups of respondents by the components under study using the Mann – Whitney U-test, correlation analysis, descriptive statistics, tabular and graphical methods. Results. The main results are given: a teacher’s professional identity model, its structural components, average values of professional identity by blocks for Latvian, Russian and Belarusian samples. Discussion and Conclusions. An international study showed that many Russian and Latvian teachers work with the awareness of the high mission of their professional activities, are aimed at developing students’ competence, cultural and value orientations, and set themselves the task of raising the level of education in society as a whole.
Formation of the System of Professional Education of the Emperor’s Russian Technical Society
Authors: Bessolitsyn Alexandr А.
Published: October 2019

Introduction. The article is devoted to the analysis of the results of the activity of the Emperor’s Russian Technical Society (ERTS) and its Permanent committee in solving problems of the professional education system development. The author focuses on the analysis of this organization’s activity in creation of the lower level of the professional education for the workers of industrial enterprises. Materials and Methods. The materials published in the journal “Technical Education” (since 1908 – “Technical and Commercial Education”) were the main source of the research, as well as the resolution of the congresses of Russian activists for technical and commercial education. During these forums a concept of professional education within the unfolding modernization was developed; the problems of relation between general and special education were discussed; main types of technical and commercial schools were studied; the problems of financing of professional schools were raised, etc. General scientific and special methods, including system analysis were used as the main research methods. Results. The author makes a conclusion that the system of professional education was developed in Russia with the participation of the civil society and ERTS and its Permanent committee for technical education, which activity was mainly focused on lower professional education, played key role in this process. The reason for this was both the request of society itself during modernization and the financial capacities of ERTS. Discussion. The system of professional education of lower level, aimed at training of workers with modern competencies was the important factor of solving problems of the human capital quality during the unfolding modernization. The development of this system was suppressed by the low level of general education among the workers of industrial enterprises. Conclusion. The conclusion is made that, in spite of the difficulties of organizational, legal and financial nature, the system of the workers’ professional education, independent from the state institutions, developed rather successfully, which contributed to solving the problems of increasing the quality of the human capital during the country’s modernization. At the same time, it is noted that ERTS and its Permanent committee failed to completely solve this problem.
The State Measure and Weight Service in Russia in the Early XX Century (on the Example of Kursk Verification Chamber)
Authors: Kravtsova Elena S.
Published: October 2019

Introduction. The development of industry and agriculture as a result of the industrial revolution of the 1830s – 1850s led the government to the idea of unification and control over the system of measurement. However, the process of establishing of a special service that could deal with the issue was very slow both due to the lack of competent specialists and the underdeveloped legislative base. And only in the early 20th century special institutions started to be founded in the provincial centers of the Russian Empire – Verification Chambers, the function of which was to check and seal up all measuring devices which were in use, purchased or manufactured. Verifications procedures were carried out both locally and extensively, in addition, unscheduled revisions were also possible. From the list of work areas it is clear that initially the chambers were founded in large commerce and industry centers, and with the flow of time the practice started spreading throughout the state. Methods. The solution of research problems was provided by a complex of complementary theoretical (analysis of scientific literature, comparative analysis, comparison, generalization, systematization) and empirical (study and generalization of published and archival sources, hermeneutical) methods. Results. The created verification chambers used to perform important functions targeted at the development of metrology and as a result the Russian Economy: accuracy of the readings of various measuring devices, control over the sealing marks, withdrawal of the fake ones, quality of measuring tools, educational activities. Conclusion. The importance of the work of this institution is confirmed by the fact that the events of 1917 which led to the collapse of the state preserved the chambers even under the new government.
“Mordovian Silk”: Development of Hemp Growing in Mordovia in the 1930–1950s
Authors: Koshina Olga V. , Skvorcova Larisa  G.
Published: October 2019

Introduction. The development of hemp growing in Mordovia in the 1930s – 1950s attracted attention of researchers due to the recent revival of interest of agricultural producers in the world, Russia and the Republic of Mordovia to the cultivation of hemp and its production. Being unheralded during the second half of the 1980s – 1990s, hemp becomes popular again in the agriculture of the Mordovia Republic, Russia and other countries. Materials and Methods. An integrative approach is used as a theoretical and methodological base of the study, microeconomic processes of a particular region against the background of macroeconomic phenomena are analyzed. Socio-economic approach allows observing the elements of material incentives within the socialist economy. Along with the analysis of economic processes, non-economic factors are taken into account. Results. Despite many climatic, socio-economic and technical problems, the cultivation of hemp in Mordovia in the 1930s – 1950s was highly profitable. Discussion and Conclusions. The success of the hemp growers contributed to: targeted state support for hemp farms, active financial incentives of collective farms and collective farmers, the development of agriculture, as well as non-economic motivation of Soviet peasants. Much success in the production of “Mordovian silk” was made by Atyashevskiy, Dubensky, Zubovo-Polyanskiy, Ichalkovsky, Kochkurovskiy, Krasnoslobodsky and Kadoshkiny districts.
Optimization of Processing Conditions of Alkali Treated Cottonii (ATC) from Sap-free Eucheuma cottonii
Authors: Fateha Fateha , Wibowo Singgih , Santoso Joko , Agusman Agusman , Uju Uju
Published: October 2019

Alkali treated cottonii (ATC) is a derivative product of Eucheuma cottoniithat is treated with alkali. This study used raw material of sap-free seaweed for ATC processing. Sap-free seaweed is a seaweed which thallus has been extracted with liquid known as sap. The use of sap-free seaweed as an ATC product is constrained by its low quality, so an effort to improve its quality is needed. Therefore the obejcetive of this Research was to get the optimal conditions of ATC processing. Experimental data were designed and analyzed using Response Surface MethodologyCentral Composite Design (RSM-CCD) using Design Expert 10.0.7® program. The optimization of ATC processing involved three components that were considered influential, namely KOH concentration, temperature, and processing time. Recommendation for optimal conditions issued by RSM-CCD on ATC processing from sap-free seawee d were 6 % KOH concentration at 75 oC for 120 minutes (93.1% desirability). The results of the response analysis showed a yield of 39.47% and a gel strength of 595.32 g/cm2. As a research control, the recommendation of RSMCCD used in ATC processing from nonsap-free seaweed was obtained yield of 36.81% and gel strength of 574.44 g/cm 2. ATC from sap-free seaweed has higher yield and gel strength than that from nonsap-free seaweed. Thismight be due to the sap-free seaweed was obtained using the proper sap extraction process and ATC processingunder optimal conditions, so that the quality of seaweed was better maintained.
Remembering the Present: Mindfulness in Buddhist Asia, by Julia L. Cassaniti
Authors: Shi (Ya-Chu Lee) Jian Cheng
Published: October 2019

Remembering the Present: Mindfulness in Buddhist Asia, by Julia L. Cassaniti. Cornell University Press, 2018. 297pp. Hb. $27.95. ISBN-13: 9781501707995.
MODELING AND SLIDING MODE CONTROL FOR A SINGLE FLEXIBLE MANIPULATOR
Authors: Hoang Nguyen Quang , Son Ha Anh
Published: October 2019

This paper concerns with modeling and control of a single flexible manipulator (SFM). The finite element method (FEM) and Lagrangian equations are exploited to establish the dynamic modeling of SFM. Firstly, the Jacobian matrix is built based on kinematic analysis. Then it is used in construction of a mass matrix for each element. The position and vibration of SFM are controlled by sliding mode controller (SMC). Its parameters are chosen by linearized equations to guarantee the stability of the system. The numerical simulation is carried out to show the efficiency of the proposed approach.
THE AMOUNT AND SPECIATION OF TRACE ELEMENTS TRANSPORTED FROM RICE FIELD TO CANAL DURING A FLOODING EVENT
Authors: Trinh Ha Thu , Duong Hanh Thi , Hoang Minh Thi Tue , Struwe-Voscul Ann Christin Struwe , Strobel Bjarne W , Le Giang Truong
Published: October 2019

Trace element pollution of soils, sediments and surface water can pose a risk for the local population and the environment of Vietnam. Rice fields can be affected by storm events, which cause the release of trace elements into surface water and transport them into drinking wells. The aim of this study was to investigate if dissolved and suspended As, Pb and Zn concentrations in surface water of a paddy rice fields and an irrigation canals increased during a flooding event and exceed the Vietnamese Surface Water Quality Standards and WHO Guidelines for Drinking-water Quality. The study site is a rice field area in the Thanh Hoa province in Central Vietnam, which experiences an average of 2.4 storms every year causing overflow of streams and low-order canals. Concentrations of As increased during the flooding event with dissolved As being the prevailing fraction, which followed a late flush behavior. Lead showed no significant difference in concentration over time. Zn concentrations only increased significantly in the canal upstream the field in the morning of the first day. Suspended Zn dominated at that time, following the first flush behavior of TSS concentrations. Concentrations of As, Pb and Zn did not exceed the Vietnamese Surface Water Quality Standards or WHO Guidelines for Drinking-water Quality at any time and they are therefore of no concern for the health of the local population
VISIBLE-LIGHT DEGRADATION OF INDIGO CARMINE USING A NOVEL MIXED METAL OXIDES/REDUCED GRAPHENE OXIDE HYBRID CATALYSTS
Authors: Nha Khanh Dang Nguyen , Mai Tho Nguyen Thi , Thang Nguyen Quoc , Tien Nguyen Thanh , Phong Chau Tan , Cang Mai Quynh , Kim Phuong Nguyen Thi
Published: October 2019

A novel ZnBi2O4/rGO hybrid catalysts had been synthesized by a simple precipitation method. The crystallinity, structural, and morphological features were studied by XRD, FE-SEM and UV-Vis diffused reflectance  techniques. The photocatalytic activity of ZnBi2O4/rGO catalysts were evaluated by degradation of Indigo Carmine dye under visible-light irradiation. The enhancement of photocatalytic properties of ZnBi2O4/rGO attributed to the synergistic effect between ZnBi2O4 and rGO, which effectively separation of the photogenerated electron-hole pairs in ZnBi2O4. Moreover, the obtained ZnBi2O4/rGO displayed high chemical stability after four consecutive experiments under visible light.
CHEMICAL COMPOSITIONS OF PASSIFLORA EDULIS SEEDS OIL COLLECTED IN VIETNAM
Authors: Cuong To Dao , Phuong Doan Lan , Anh Nguyen Van Tuyen , Khanh Pham Ngoc , Huong Tran Thu , Cuong Nguyen Manh
Published: October 2019

The present research was aimed to study the chemical compositions of Passiflora edulis Sims seeds oil, including the fatty acid profiles, contents of tocopherols, sterols, and triglycerides. The seeds oil yield is 24.88% by using Soxhlet method. Passiflora edulis seeds oil showed high levels of unsaturated fatty acids (89.25%) with main ingredient linoleic acid (w-6, 66.94%) and oleic acid (w-6, 18.86%). Tocopherols (18.04 mg/kg), sterols (2935.35 mg/kg) and triglycerides (monomere TAG, 74.11%) are also determined by using IOC and ISO methods, respectively. The findings demonstrate that P. edulis seeds oil could be used beneficially in the food and cosmetic industries.
2018 Genel Seçimleri Odaklı TV’de Yayımlanan Siyasal Reklamların Çekicilikler Bağlamında Analizi
Authors: ÇALAPKULU Çiğdem , BOZDEMİR Yasin
Published: October 2019

Demokratik toplumlarda
girilen iktidar mücadelesinde vatandaşlara bilgi vermek, tutumlarını
değiştirebilmek, ikna edebilmek amaçları doğrultusunda siyasi iletişim kaçınılmaz
bir gerekliliktir. Siyasi iletişimin en önemli kollarından birisini siyasal
reklamlar oluşturur. Seçim sonuçlarını etkileyen önemli değişkenlerden birisi
de siyasal iletişim ve siyasal kampanyalardır. Siyasal iletişimin başarısını
belirleyen en önemli faktörlerden birisi olan ikna, birçok farklı mesaj içeriği
ile oluşturabilir. Seçim dönemlerindeki siyasal kampanyalarda kullanılan reklam
çalışmalarında, ikna stratejilerinden çekicilikler yoluyla hedefteki seçmen
kitlenin ikna edilebilmesi amaçlanır. Bu çalışmada, 24 Haziran 2018 genel
seçimleri çerçevesinde milletvekilliği adaylıklarının resmi olarak açıklandığı
30 Mayıs 2018 tarihinden sonra ulusal kanallarda yayımlanan AKP/MHP/CHP/İYİ
PARTİ ve SP adlı siyasi partilerin siyasal reklam filmlerinden öne çıkan her
bir tanesi göstergebilimsel incelemeye tabi tutulmuştur. Bunun sonucunda
incelenen reklamlardan elde edilen ikna bağlamındaki reklam çekicilik
bulguları, sınıflandırılıp partiler özelinde analiz edilerek bu durumun 2018
genel seçim sonuçlarına yansıması ve katkısı yorumlanacaktır.
Fotoğrafta Gözetleme Olgusu Üzerine Bir İnceleme
Authors: GÖKTAN Mustafa Çağatay
Published: October 2019

Fotoğraf makinesi yapısı
gereği kaydettiği şeyleri teşhir eden özelliğe sahip bir araçtır. Ortaya
çıkardığı görüntülerin bu niteliği dolayısıyla da icadından günümüze kadar olan
süreçte hem üreticileri hem de izleyicileri açısından birçok tartışmaya konu
olmuştur. Özellikle belgesel fotoğrafta, çekilen konunun daha samimi,
inandırıcı ve dikkat çekici olabilmesi adına doğallığının bozulmaması
gerektiğine ilişkin görüşü savunanlar, gözetledikleri şeylere karşı kayıt
edildiklerinin farkında olmayacakları bir yaklaşım benimsemektedirler. Aslında
bu tutum, hem gözetlenen hem de kayıt altına alınan insanların kişisel
haklarına yapılmış bir ihlali de beraberinde getirebilmektedir. Bu makale
fotoğraf üretimini dikizcilik kavramı bağlamında bireyin kendisini en rahat
hissettiği özel yaşam alanlarını konu alan çalışmalar üzerinden incelemeyi ve
değerlendirmeyi amaçlamaktadır. Ele alınan konuya ilişkin metin ve eser
analizleri içeren bu çalışmanın kuramsal araştırmalara katkı sağlaması
hedeflenmektedir.
II. Abdülhamid Döneminde Yemen Zeydîlerinin Osmanlı Hilâfetine Bakışı
Authors: BARLAK Yasemin
Published: October 2019

XIX. yüzyıldan itibaren Batılı devletlerin Osmanlı toprakları
üzerindeki işgal hareketleri gittikçe arttı. Sultan II. Abdülhamid, Müslüman
toplumlar arasında halifelik iddiasıyla ayrılıkçı hareketlerin başlaması
tehlikesine karşı sürekli tetikte olmak durumunda kaldı. Kendilerini “halife”
olarak isimlendiren ve Hz. Muhammed’in soyundan geldiklerini ifade eden Zeydî
imamlar, daha önce Yemen’in iç bölgelerini kendi kontrolleri altında
tutmaktaydı. Osmanlı Devleti 1872’de gerçekleştirdiği önemli bir harekât
sonrasında Yemen hâkimiyetini iç kesimleri de kapsayacak şekilde genişletti.
Zeydî imamlar yeni gelişmelerden oldukça rahatsızlık duydular. Özellikle bir
takım dinî gerekçeler gösterip, Tanzimat’ın ilanı ile birlikte gayrimüslimlere
verilen hakların artırılmasını öne sürerek yönetime karşı sık sık isyan etmeye
başladılar. İmam Yahya ile Osmanlı yönetimi arasında gerçekleşen uzlaşma çabaları
II. Abdülhamid’in tahttan indirilmesi ile sonuçsuz kaldı.
Sosyal Sermaye ve İnovasyonun Belirleyicileri; Düzce İli İçin Bir İnceleme
Authors: KOÇ Recep , OĞUZTÜRK Bekir Sami
Published: October 2019

Türkiye’nin iki büyük şehri İstanbul ve Ankara’nın arasında merkezi bir coğrafi konuma sahip olan Düzce ilinin umulan refah seviyesine ulaşılmasında özellikle kişi başı geliri artırıcı katma değerin inovasyonla yapılacağı düşünülen çalışmada; inovasyonu artırıcı bir unsur olarak sosyal sermayenin mevcudiyetinin iyileştirilmesi gerekmektedir. Buna istinaden, çalışmanın literatür bölümünde konuya yön gösterecek yapılan çalışmaların özetlerine yer verilmiştir. Çalışmada yapılmak istenen analiz ile ilgili göstergeler belirlenmeye çalışılmıştır. Veri analizinde, inovasyon ve sosyal sermaye ile ilgili göstergelerin en anlamlı sonuçlar verecek gösterge ve faktör yüklerini elde etmek için faktör analizleri yapılmıştır. Analiz sonuçlarına göre sosyal sermaye belirleyicileri içerisinde en fazla etkisi olan değişkenin bin kişi başına düşen STK sayısı, inovasyon için ise MARKA TESCİL sayısı olarak görülmüştür
Son Dönem Çağatay Türkçesinde “-AdUrGAn” Yapısının Mahiyeti ve İşlevleri
Authors: EKER Ümit
Published: October 2019

Çağatay
Türkçesinde genel olarak hareket ismi veya geçici sıfat yapma görevinde
kullanılan “-GAn” eki, müstakil
kullanımının yanında son dönem Çağatay Türkçesinde zaman zaman “-AdUrGAn” şeklinde de görülebilmektedir.
Yapı bu şekliyle eklendiği fiilde geniş / şimdiki zamanda fiilin bir müddet
sürdüğünü ortaya koyar. Ekin genişleyerek “-AdUrGAn”
şeklini almasında “-GAn” ekindeki
işlev çeşitlenmeleri nedeniyle geniş zaman anlamının zayıflamasının önemli
etkisi vardır. Yapıda, geniş / şimdiki zamanda fiilin bir müddet devam ettiği
veya hâlen devam etmekte olduğu anlamını ortaya koymak için “-GAn” ekinin önüne “-AdUr” yapısı getirilmiş ve süreç içinde bu üç unsur kalıplaşmıştır.
İlk kez klasik öncesi, yoğunluklu olarak da klasik sonrası devir Çağatay
Türkçesi döneminde kullanılan yapı, yalnız başına ve geniş zamana bağlı bir
hareket gösteren geçici bir isim olarak kullanılabildiği gibi iyelik, çokluk ve
isim çekimi eklerini de alabilmekte, yüklem olarak da kullanılabilmektedir. “-AdUrGAn” yapısının yerini Çağatay Türkçesinin
ardılı Özbek Türkçesinde “-(ä)yåtgän”
ve “-(ä)digän” / “-(y)digän” / “-(ä)dirgän” biçimleri almıştır.
ABD'nin Avrupa Enerji Pazarına Yönelik İzlediği Dış Politika: Kaya Gazı Devrimi ve Avrupa Pazarında Rus Hâkimiyetine Karşı LNG Hamlesi
Authors: SIVIŞ Efe
Published: October 2019

Bu makale, Avrupa gaz pazarının kapasitesini ve
Rusya'nın ana gaz tedarikçisi olduğunu göz önünde bulundurmak suretiyle, Avrupa
gaz pazarının halen gelişme sürecinde olan Kuzey Amerika gazı için henüz
yararlanılmamış bir kaynak olduğunu ortaya koymaktadır. Çalışma, ABD ve
Rusya’nın enerji sektörü özelinde ilişkilerine jeopolitik çerçevede geniş ve
kapsamlı genel bir bakış sunmakta, diğer yandan hem ABD hem de Rusya’nın enerji
politikası için Avrupa enerji piyasasının önemini vurgulamaktadır. Makalede,
güvenlikleştirme teorisi ve enerji güvenliği kavramları çerçevesinde ABD’nin
dış politikasının analiz edilmesi amaçlanmaktadır. Çalışmada yöntem olarak
ABD’nin bölgeye ilişkin enerji politikaları bölgeselcilik kavramı çerçevesinde
analiz edilmiştir. Çalışmanın sonucu, ABD’nin Avrupa doğal gaz piyasalarındaki
çıkarının, yalnızca Avrupa’nın Rus doğal gazına olan bağımlılığını azaltma
konusunda ‘yardım etmenin’ ötesinde olduğunu, ABD’nin nihai dış politika
hedefinin Avrupa’nın önde gelen bir doğal gaz tedarikçisi olarak tebarüz etmek
olduğunu öngörmektedir.
The Effect Of Liquidity On Liabilities: An Application In Automotive Companies
Authors: DAYI Faruk , ÇETİNKAYA Reşit
Published: October 2019

Liquidity refers to the ability of an enterprise to pay off
its short or long term liabilities. The higher the profit of companies, the
more the liquid assets. The sales, and consequently the profits of automotive
companies operating in Turkey have been increasing in the last few years. Liquidity
is expected to increase with the increase of profits. The aim of the study is
to investigate the correlation between solvency and liquidity of automotive companies. In the
application, the eight-year (2010-2017) financial statement data of 11 automotive
companies operating in the Istanbul Stock Exchange (Turkey) were used. A panel
data analysis was conducted using financial leverage ratio, cash, receivables,
inventories, liabilities and revenue variances obtained from the financial
statement data. It was determined that automotive companies had 54 percent of
their assets in debts. As a result of the analysis, it was determind that there
was a positive correlation between financial leverage ratio and receivables,
liabilities and inventories, whereas there was a negative correlation between
financial leverage ratio and revenues and liquid assets.
A Phase I Trial Using a Multitargeted Recombinant Adenovirus 5 (CEA/MUC1/Brachyury)-Based Immunotherapy Vaccine Regimen in Patients with Advanced Cancer
Authors: Gatti-Mays Margaret E. , Redman Jason M. , Donahue Renee N. , Palena Claudia , Madan Ravi A. , Karzai Fatima , Bilusic Marijo , Sater Houssein Abdul , Marté Jennifer L. , Cordes Lisa M. , McMahon Sheri , Steinberg Seth M. , Orpia Alanvin , Burmeister Andrea , Schlom Jeffrey , Gulley James L. , Strauss Julius
Published: October 2019

Lessons Learned

Concurrent ETBX-011, ETBX-051, and ETBX-061 can be safely administered to patients with advanced cancer. All patients developed CD4+ and/or CD8+ T-cell responses after vaccination to at least one tumor-associated antigen (TAA) encoded by the vaccine; 5/6 patients (83%) developed MUC1-specific T cells, 4/6 (67%) developed CEA-specific T cells, and 3/6 (50%) developed brachyury-specific T cells. The presence of adenovirus 5-neutralizing antibodies did not prevent the generation of TAA-specific T cells.

Background

A novel adenovirus-based vaccine targeting three human tumor-associated antigens—CEA, MUC1, and brachyury—has demonstrated antitumor cytolytic T-cell responses in preclinical animal models of cancer.

Methods

This open-label, phase I trial evaluated concurrent administration of three therapeutic vaccines (ETBX-011 = CEA, ETBX-061 = MUC1 and ETBX-051 = brachyury). All three vaccines used the same modified adenovirus 5 (Ad5) vector backbone and were administered at a single dose level (DL) of 5 × 1011 viral particles (VP) per vector. The vaccine regimen consisting of all three vaccines was given every 3 weeks for three doses then every 8 weeks for up to 1 year. Clinical and immune responses were evaluated.

Results

Ten patients enrolled on trial (DL1 = 6 with 4 in the DL1 expansion cohort). All treatment-related adverse events were temporary, self-limiting, grade 1/2 and included injection site reactions and flu-like symptoms. Antigen-specific T cells to MUC1, CEA, and/or brachyury were generated in all patients. There was no evidence of antigenic competition. The administration of the vaccine regimen produced stable disease as the best clinical response.

Conclusion

Concurrent ETBX-011, ETBX-051, and ETBX-061 can be safely administered to patients with advanced cancer. Further studies of the vaccine regimen in combination with other agents, including immune checkpoint blockade, are planned.
Demans Hastalarına Bakım Verenlerin Uyku Kalitelerinin Değerlendirilmesi
Authors: HAMAMCI Mehmet , BOZKURT Gurbet , KARAASLAN Özgül , HACIMUSALAR Yunus , BÜYÜKKIZMAZ Mustafa , İNAN Levent Ertuğrul
Published: October 2019

Amaç: Bu
çalışmada orta ve ağır evre Alzheimer hastalarına bakım veren aile üyelerinin
depresyon, anksiyete ve uyku kalitelerinin sağlıklı kontrollerle
karşılaştırılması amaçlandı.

Materyal
ve Metod:
Bu prospektif, kesitsel çalışmaya orta veya ağır evre Alzheimer hastalarına
bakım veren 18-65 yaş arası, en az ilkokul mezunu olan 29 kişi ile bakım verme
öyküsü olmayan 30 sağlıklı kontrol grubu dahil edildi.  Olgulara demografik verileri içeren anket
soruları, Pitssburgh Uyku Kalitesi İndeksi (PUKİ), Beck Depresyon Ölçeği (BDÖ)
ve Beck Anksiyete Ölçeği (BAÖ) uygulandı.

Bulgular:
Alzheimer hastalarının yaş ortalaması 74,52±8,23 yıl idi. Alzheimer
hastalarının 14’ü (%48,3) kadın, 15’i (%51,7) erkekti. Alzheimer hastalarına
bakım verenlerin yaş ortalaması 42,31±10,01, kontrol grubunun yaş ortalaması
37,87 ±11,08 idi. Yaşlar arasında anlamlı fark yoktu (p=0,111). Gruplar arasında cinsiyet açısından da anlamlı fark
yoktu (p=0,322). Alzheimer hastalarına bakım verenlerin BDÖ median değeri 7
(min:2, max:19) yıl olup sağlıklı kontrol grubunun BDÖ median değeri 10 (min:6,
max:36) yıl idi. Bu fark istatiksel olarak anlamlıydı (p=0,001). Bakım
verenlerin BAÖ median değeri 5 (min:2, max:16) yıl olup sağlıklı kontrol
grubunun BAÖ median değeri 6 (min:4, max:17) yıl idi. Bu fark istatiksel olarak
anlamlıydı (p=0,026). PUKİ toplam puanlarına göre bakım verenlerin  %51,7’sinde (n=15), sağlıklı kontrol grubunun
%23,7’sinde (n=12) uyku kalitesi kötüydü ve bu fark anlamlıydı (p=0,047). 

Sonuç:
Alzheimer hastalarına bakım verenlerde ölçek puanlarına göre anksiyete ve
depresyon puanları daha yüksek bulunmuş olup ayrıca uyku kalitelerinin de daha
kötü olduğu tespit edilmiştir.
AS EXPORTAÇÕES DA REGIÃO SUL DO BRASIL: UMA ANÁLISE DO SETOR AGROPECUÁRIO
Authors: Claudy da Silveira Daniel , Feistel Paulo Ricardo , Brum Argemiro Luís
Published: October 2019

Este artigo tem o objetivo analisar os fluxos de comércio dos principais produtos do setor agropecuário (soja, fumo e carnes) exportados pela Região Sul do Brasil, a seus principais mercados de destino (Argentina, China, Estados Unidos e União Europeia), através de um modelo gravitacional, por estimação de dados em painel, com a abordagem de mínimos quadrados ordinários (MQO–Pooled), no período de 2000 a 2012. A estimação do modelo gravitacional apresentou resultados que seguem as estimativas dos trabalhos seminais da literatura econômica. No mesmo se demonstra que, no período analisado, os fluxos do setor agropecuário da Região Sul sofrem influência negativa da distância entre os países e, por outro lado, positivamente em relação à massa populacional e a taxa de câmbio real sobre os fluxos comerciais entre os países considerados.
Inovação Social e Construções Solidárias: o caso das Agroindústrias familiares no Semiárido da Paraíba – Brasil
Authors: Sales Ricélia Maria Marinho , Dos Santos Silva Maria Da Paz Nascimento , Cândido Gesinaldo Ataíde , Sales Luís Gustavo de Lima
Published: October 2019

O objetivo foi analisar as agroindústrias familiares no tocante à diversificação da atividade da agricultura no Semiárido da Paraíba – Brasil. Os aspectos metodológicos se pautaram em dois conceitos estruturadores, quais sejam: a economia solidária e a inovação social. Os procedimentos adotados foram: sensibilização in lócus; prospecção; levantamento bibliográfico e análise descritiva. Quanto aos resultados destacaram-se as experiências construídas de modo intuitivo por parte das agricultoras e agricultores e, no momento seguinte, a busca por organização que resultou no Fórum Sertanejo da Economia Solidária, que dá um apoio no tocante à orientação das práticas coletivas. Portanto, houve o fortalecimento das Associações: Várzea Comprida dos Oliveiras, localizada em Pombal/PB; Riacho dos Currais em São Bentinho/PB e; Poços de Baixo em Teixeira/PB; e, consequentemente a constituição das agroindústrias “Bolo das Oliveiras”, “Emana Mel” e “Sabor da Serra”, que contam com 19, 12 e, 25 agricultores e agricultoras. A produção varia entre fabricação de bolos e derivados da panificação, passando pelo beneficiamento de mel e, processamento de polpa de frutas. Estas atividades produtivas estão se destacando na região tanto pelo modo de organização quanto pelo papel preponderante das mulheres no tocante a liderança. Desse modo, tem garantido a soberania e a segurança alimentar e nutricional, primeiro na comunidade rural e, depois, influenciando os hábitos alimentares nas cidades, controlando e evitando o desperdício de alimentos, além de contribuir com a preservação dos elementos da natureza. Concluiu-se que as ações desenvolvidas estão se revelando como contribuições para a transformação da agricultura familiar.
On Overcoming Corruption Barriers in the Services' Market Formation in the Common Economic Space of the Eurasian Economic Union
Authors: Kurochkin Denis
Published: October 2019

The contractual and legal basis of the Eurasian Economic Union (EAEU) provides for the creation of the common economic space and a common market of services without any administrative, fiscal or other barriers. In fact, access to the market of services is limited by various barriers that possess corruption-generating properties. The paper describes the importance of cooperation between EAEU members in counteracting corruption with the purpose of economic integration. The implementation of the UN Convention against Corruption and other global instruments at the EAEU level is significant because it simplifies the processes of economic integration by overcoming the existing administrative barriers. The author discusses some administrative barriers that prevent investors working in special economic zones from accessing the service market, including those connected with determining the types of activities for special economic zones, selecting the projects of special economic zones participants, drawing contractual agreements between investors and the administration of a special economic zone. The author also summarizes the doctrinal position on the interaction between global and regional instruments of counteraction corruption, studies the impact of corruption on the formation of the common economic space, the volume of foreign investment and other economic aspects of regional integration. He outlines the necessity of overcoming administrative, fiscal and other barriers that have corruption-generating properties by adopting the Eurasian Anticorruption Strategy as a more flexible document that could make it possible to implement the key clauses of the UN Convention against Corruption in the Eurasian conditions and use the experience of creating a regional system of counteracting corruption-generating administrative barriers in the legal systems of APEC, OECD and the Council of Europe.
Reputation Management. Sabrina Helm; Kerstin Liehr-Gobbers; Christopher Storck. Heidelberg/Berlin: Springer (2011).
Authors: Salgado Paulo
Published: October 2019

O livro Reputation Management é a mais recente publicação internacional sobre o cada vez mais actual conceito de reputação organizacional...
Violent objects: the forms of pathos in Yael Martinez, Glenna Gordon and Eugênio Grosso’s compositions
Authors: Casadei Eliza Bachega , Duccini Mariana
Published: October 2019

This article aims to investigate the photographers’ Yael Martínez, Glenna Gordon and Eugenio Grosso artistic works. Their photographs highlight the violence in representation of consumer goods which evoke the extended relations between the subjects and their personal belongings. This is a way to discuss the iconological status in such objects which are then converted in other significations patterns. The study of these artists’ composition strategies allows us to analyze the pathos-forms achieved by the anachronistic and dialectical montage which links the referential aspects and the decrease of iconological status in these images.
“Dulce et decorum est”: The Phenomenon of Martyrdom in Western Nationalisms of the 18th–20th Centuries
Authors: Zygmont Aleksei
Published: October 2019

The article considers the phenomenon of martyrdom in the Western nationalisms of the 18th–20th centuries, and is analyzed in three examples. These are the cults of Marat, Lepelletier, Chalier, and other martyrs in France during the 1789 French Revolution; the cult of Abraham Lincoln and other “martyr president” cults in the USA; and the Irish martyrdom ideologies from the 17th century to the 1916 Eastern Rising. The classic studies on nationalism (E. Gellner, B. Anderson, E. Hobsbawm, etc.) do not pay attention to the topic. Other works consider separate cases, though lack a general theory. Thus, the article’s major goals are to discover what is the role of martyrdom in nationalisms, and how is it related to religious ideas. In order to answer these questions, the author proposes a structural, or “compositional”, model, suggesting that the discourse of martyrdom consists of the three motives of founding, militancy, and mobilization. These three components work as an integral “engine” that allows a nationalist movement or a nation-state to fight to create the new reality and preserve what was created. The author suggests that the balance of these three motives in each individual case may differ, so one of the motives may be hypertrophied, while the other two motives are simply “completed” to the minimum level. Proceeding from the fact that martyrdom in nationalisms constantly refers to religious ideas, images, and rituals, the author concludes that martyrdom is an integral phenomenon with no clear borderline between “secular” or “religious” with regard to both individual cases and the elements of a much larger case.
An Ontology of Power as an Ontology of History: An Appraisal of Vladimir Bibikhin’s Political Philosophy
Authors: Pavlov Ilia
Published: October 2019

The paper deals with the phenomenological, ontological, and existential grounds of the political philosophy and the philosophy of history as proposed by Vladimir Bibikhin in a course of lectures called (It’s) Time (Time-Being). Following the crucial ideas of Martin Heidegger’s Being and Time, Bibikhin introduces the concepts of “early” and “late” disciplines, illustrated by the rules of Sophia Alekseyevna and Peter the Great, accordingly. These concepts are introduced to indicate two different ontological structures of historical and political action. An ‘early’ discipline stands for an ontological basis for democracy, whereas a ‘late’ one refers to autocracy and despotism. Drawing on multiple Bibikhin’s works dedicated to Russia, such as Introduction to the Philosophy of Law, The Power of Russia, and Our Place in the Word, the author argues that Bibikhin further elaborates the political and ontological aspects of the above-mentioned concept of the ‘late’ discipline in these texts. In contrast, the book New Renaissance is considered as an illustration of an ‘early’ discipline which is prevalent in the West, according to Bibikhin. Finally, the author proposes a critical evaluation of Bibikhin’s political philosophy in regards to its close link with an ideology and outlines the possible perspectives of implementing some of Bibikhin’s ideas in contemporary debates about the political.
“Trustworthiness is the Foundation of Right”: Confucian Trustworthiness as an Existential Principle of Japanese Political Culture of the Nara Period
Authors: Matveenko Valentin
Published: October 2019

The author attempts to analyze several categories of the Japanese political culture of the Nara period of the 7th–8th centuries AD, such as harmony (wa 和), and righteousness (gi 義). The author supposes that the existential disposition of trust forms the basis for such categories. In Confucian tradition, this disposition is expressed through trustworthiness (sin 信). The article begins with an overview of the Japanese political culture of the Nara period in order to clarify the place of wa, gi, and sin in Japanese political thought. The author pays close attention to the roles of language and myth in Japanese culture as well. It is argued that political culture is a sort of superstructure for language, which is a substructure. Since language is the logos of culture as a whole, it is possible to identify the existential meanings of categories of political culture that are ontologically rooted in language. The author claims that the patterns of political thinking in Japanese tradition are reflected in myth. In order to prove this, the authors offers an analysis of the use of such characters as wa 和 and gi 義 in the Japanese chronicles Kojiki and Nihongi, highlighting the variety of their meanings and the close connection with trustworthiness as their basis.
Democracy and Terrorism: A Re-analysis
Authors: Korotayev Andrey , Vas'kin Il'ya , Romanov Daniil
Published: October 2019

The authors analyze the relationship between the type of political regime and the level of terrorist activity, with a particular emphasis on the so-called factional democracies. The key difference of factional democracies from other political regimes is the presence of polarization between opposing factions. It has been reported that political polarization transforms the conventional institutionalized political process into unconventional politics. The authors draw attention to the fact that in the existing scientific debate, there is no clear conclusion about the nature of the relationship between the type of political regime and the level of terrorist activity in the country. A literature review suggests that there is a curvilinear, U-shaped relationship between the level of terrorist activity and the type of political regime, which is consistent with the findings of previous works describing the relationship between socio-political destabilization and the type of political regime. Preliminary testing conducted by the authors indicates that factional democracies are subject to significantly more terrorist attacks than any other political regimes. While analyzing data on the level of terrorist activity, the authors address the need to split the sample into subsamples, due to the nonlinear nature of the relationship between the level of terrorist activity and GDP per capita, as well as the mean of years of schooling. The presence of a positive relationship between factional democracies and the level of terrorist activity is also verified by applying a negative binomial regression. The authors offer their own answer to the question of why so many previous studies have detected a positive correlation between democracy and terrorism. Attention is drawn to the fact that the positive relationship between democratic regime and the level of terrorist activity can be obtained due to the inclusion of factional democracies into the overall sample of democratic states. If factional democracies are excluded from the sample, the relationship between the level of terrorist activity and the democratic regime turns out to be clearly negative. The findings about the relationship between regime type and terrorist activity are replicated at the subsamples level. The general conclusion is that a factional democracy turns out to be a very strong positive predictor of high levels of terrorist activity, whereas a non-factional democracy turns out to be a statistically-significant predictor of the relatively lower levels of the intensity of terrorist attacks.
Оценка влияния запуска Московского центрального кольца на арендные ставки жилой недвижимости
Authors: Стахно Даниил Владимирович
Published: October 2019

Начало пассажирских перевозок по Московскому центральному кольцу (МЦК) оказало значительное и разноплановое влияние на развитие города. Статья посвящена исследованию одного из важных эффектов — изменению ставок аренды жилья вследствие улучшения его транспортной доступности. Данные по рынку аренды жилья Москвы были доступны на момент, когда до запуска МЦК оставалось полгода, на момент запуска и спустя семь месяцев после него. Использование гедонистической модели цен позволило выявить положительный вклад роста доступности станций МЦК в формирование ставок аренды по всей территории города после запуска новой транспортной системы. Удалось показать, что непосредственно у станций продолжают вносить свой вклад отрицательные факторы проживания рядом с железной дорогой, однако их влияние также постепенно снижается. Значимым результатом стало также выявленное различие эффекта МЦК в зависимости от преобладающего способа использования территории вокруг станции. Максимальный эффект наблюдается в случае многофункционального использования территорий, а в жилых микрорайонах с легким доступом к метрополитену появление МЦК не вызвало ощутимого эффекта в части формирования арендных ставок. От появления МЦК выиграли преимущественно жилые районы с затрудненным доступом к метро и немногочисленные жилые объекты в промышленных зонах, однако использованная модель не дает возможности сделать однозначные выводы о характере влияния на территориях с иными характеристиками. Тем не менее в целом положительный характер эффекта может свидетельствовать о наличии неявных выгод для экономики города, косвенным образом компенсирующих высокую стоимость подготовки МЦК к запуску.
Велосипед и безопасность в городе: развитие транспортной инфраструктуры
Authors: Малыхин Константин Ильич
Published: October 2019

В данной работе исследуется проблема безопасности велосипедистов на дороге. Современное состояние велосипедной инфраструктуры в Санкт-Петербурге не позволяет велосипедистам чувствовать себя в безопасности при передвижении по городу, а также отталкивает граждан от использования велосипеда, что подтверждает опрос населения, проведенного Санкт-Петербургским городским центром управления парковками.

Для выявления наиболее опасных районов для передвижения на велосипеде были проанализированы открытые данные ГИБДД по дорожно-транспортным происшествиям с участием велосипедистов с 2015 по 2017 годы, а также исходные данные опроса СПб ГЦУП. С помощью данных опроса были смоделированы велосипедные потоки по районам города, а использование статистики ДТП позволило выявить аварийноопасность районов города. Предобработка и анализ данных ДТП выполнялись с помощью языка программирования R в RStudio.

В результате, благодаря использованию открытых государственных и городских данных, был смоделирован велопоток по районам города, а также выявлены наиболее аварийноопасные его районы, в первую очередь нуждающиеся в создании безопасной велосипедной инфраструктуры. Также в рамках популяризации велосипедного движения сформулированы рекомендации государственным органам власти Санкт-Петербурга.
Работа турникетной системы как элемент пассажирского опыта
Authors: Глазков Константин Павлович , Деев Михаил Михайлович , Шаулин Федор Валентинович
Published: October 2019

В рамках исследования мы рассматриваем турникеты как в большинстве случаев неотъемлемую часть пассажирского опыта. Турникеты — это не просто технология контроля оплаты проезда, но и устройства, определяющие взаимодействие пассажиров в пространстве транспорта и нормирующие их телесность. Турникеты преобразуют разнообразие пассажирской телесности в нормированные единицы, образующие обсчитываемый и управляемый пассажиропоток. Посредством турникетов организуется особая последовательность действий пассажиров в до- и после-турникетных зонах, служащих местом встреч и прощания, обеспечивается «справедливость» очередности посадки и выбора мест пассажирами. С другой стороны, турникеты являются точками разрыва и прерывания взаимодействия между пассажирами. Периодически с турникетами случаются поломки, в их зоне возникают непредвиденные ситуации. Нормальное функционирование турникетов предполагает владение «турникетными» практиками пассажирами и персоналом транспортных организаций. Некоторые категории пассажиров (дети, «сумчатые», пожилые и крупногабаритные) могут испытывать трудности при прохождении турникетов, причиняя неудобство себе и окружающим. Безусловно, практики пользования турникетами имеют противоречивые коннотации, но не остается сомнений, что турникеты существенно влияют на пассажирский опыт москвичей, тем самым являясь прямой реализаций транспортной политики по становлению пассажира нового типа – более дисциплинированного и ответственного. Эмпирическим материалом исследования послужили видеозаписи практик использования турникетов в различных видах транспорта Москвы, собранные в декабре 2017-го и весной 2018 года.1

[1] Исследование выполнено при поддержке Российского научного фонда (проект РНФ №17-78-20164) «Социотехнические барьеры внедрения и использования информационных технологий в современной России: социологический анализ».