bluuebunny/crossref_metadata_2025 huggingface dataset:
Expecting the Unexpected: Entropy and Multifractal Systems in Finance
Authors: Orlando Giuseppe , Lampart Marek
Published: November 2023

Entropy serves as a measure of chaos in systems by representing the average rate of information loss about a phase point’s position on the attractor. When dealing with a multifractal system, a single exponent cannot fully describe its dynamics, necessitating a continuous spectrum of exponents, known as the singularity spectrum. From an investor’s point of view, a rise in entropy is a signal of abnormal and possibly negative returns. This means he has to expect the unexpected and prepare for it. To explore this, we analyse the New York Stock Exchange (NYSE) U.S. Index as well as its constituents. Through this examination, we assess their multifractal characteristics and identify market conditions (bearish/bullish markets) using entropy, an effective method for recognizing fluctuating fractal markets. Our findings challenge conventional beliefs by demonstrating that price declines lead to increased entropy, contrary to some studies in the literature that suggest that reduced entropy in market crises implies more determinism. Instead, we propose that bear markets are likely to exhibit higher entropy, indicating a greater chance of unexpected extreme events. Moreover, our study reveals a power-law behaviour and indicates the absence of variance.
Balancing Livestock Environmental Footprints with Forestry-Based Solutions: A Review
Authors: Solomon Tamirat , Gupta Vaishali , Ncho Chris Major
Published: November 2023

Livestock production, as one of the oldest and most significant human activities, plays a vital role in fulfilling the global demand for human nutrition and other animal-related products while contributing to poverty reduction. However, it is also important to address the environmental impact of livestock animals. Over 60% of the global biomass harvested annually to support human activity is directed towards this sector, raising concerns about its sustainability. In addition to substantial water and fertilizer usage reported in recent years, it is estimated that 14.5% of global greenhouse gas emissions are generated by the livestock sector. Furthermore, the increasing amount of manure resulting from intensive animal farming raises concerns about its disposal and potential water pollution. The degradation of pasture and rangeland is another significant contributor to soil erosion. Multiple approaches are being studied to reduce the environmental impact of livestock production, but a sustainable alternative may be through forestry. Forests play a vital role in countering livestock emissions by absorbing billions of tons of carbon dioxide each year, and they act as a crucial carbon sink. Furthermore, the diversity and age of forests impact the carbon sequestration process. Forests also help to combat climate change by reducing soil erosion and regulating the water cycle. As such, sustainable forest management is essential as forests provide multiple benefits, including economic, environmental, and social benefits, while also sequestering carbon. In this review, the current impact of modern livestock production is described, along with the potential for mitigating it through forestry-based solutions.
Experimental Study on Macroscopic Spray and Fuel Film Characteristics of E40 in a Constant Volume Chamber
Authors: Tian Huayu , Wang Jun , Zhang Ran , Zhang Yulin , Su Yan , Yu Hao , Shen Bo
Published: November 2023

In the modern industrial field, there is a strong emphasis on energy-saving and emission reduction. Increasing the amount of ethanol in ethanol–gasoline blends has the potential to replace fossil fuel gasoline more effectively, improving energy efficiency and lowering emissions. The interaction between liquid fuel film generation on the piston crown and spray impingement in the combustion chamber in the setting of GDI engines has a substantial impact on particle emissions and engine combustion. In this study, 92# gasoline and ethanol by volume are combined to create the ethanol–gasoline blend E40. The spray characteristics and film properties of both gasoline and the intermediate proportion ethanol–gasoline blend E40 were researched utilizing a constant volume combustion platform and the schlieren method and refractive index matching (RIM) approach. The results show that, for 0.1–25 operating conditions, gasoline consistently displays greater macroscopic spray characteristic parameters than E40. This shows that gasoline fuel spray evaporation is superior to E40. Similar results are seen in the analysis of wall-attached fuel films, where the volume and thickness of the gasoline film are less than those of the E40 film under the given operating conditions. In contrast, E40 consistently exhibits stronger macroscopic spray characteristic values than gasoline under the 0.1–150 and 0.4–150 operating conditions, along with lower film thickness and volume. As a result, under these two operating conditions, E40 fuel performs better during spray evaporation.
European Green Deal: An Experimental Study of the Biomass Filtration Combustion in a Downdraft Gasifier
Authors: Golub Gennadii , Tsyvenkova Nataliya , Kukharets Savelii , Holubenko Anna , Omarov Ivan , Klymenko Oleksandra , Mudryk Krzysztof , Hutsol Taras
Published: November 2023

This study presents the experimental results obtained from hybrid filtration combustion using biomass pellets. The experiments were carried out using a porous media gasifier filled with pellets and inert material. The gasifying agent used was an air–steam mixture, with 40% being steam. The dependence of the temperature in the gasifier’s reaction zone from the volume percentage of inert porous material in the gasifier, the specific heat capacity of this material, as well as the air–steam blowing rate, was investigated. The multifactor experiment method was used. A maximum temperature of 1245 °C was achieved using 28 vol% of porous material with a heat capacity of 1000 J/(kg·°C) and at a blowing rate of 42 m3/h. The maximum hydrogen content in the syngas was 28 vol%. This was achieved at an air–steam blowing rate of 42 m3/h and 40 vol% porous material, with a heat capacity of 1000 J/(kg·°C). The calorific value of the syngas was 12.6 MJ/m3. The highest CO content in the gas was 28 vol% and was obtained at 20 vol% porous material with a heat capacity of 1000 J/(kg·°C) and a blowing rate of 42 m3/h. The obtained information is applicable in the design, management, and control of gas production by way of a hybrid filtration combustion process in a downdraft gasifier.
Literature Review of Hydrogen Energy Systems and Renewable Energy Sources
Authors: Kyriakopoulos Grigorios L. , Aravossis Konstantinos G.
Published: November 2023

The role of hydrogen as a clean energy source is a promising but also a contentious issue. The global energy production is currently characterized by an unprecedented shift to renewable energy sources (RES) and their technologies. However, the local and environmental benefits of such RES-based technologies show a wide variety of technological maturity, with a common mismatch to local RES stocks and actual utilization levels of RES exploitation. In this literature review, the collected documents taken from the Scopus database using relevant keywords have been organized in homogeneous clusters, and are accompanied by the registration of the relevant studies in the form of one figure and one table. In the second part of this review, selected representations of typical hydrogen energy system (HES) installations in realistic in-field applications have been developed. Finally, the main concerns, challenges and future prospects of HES against a multi-parametric level of contributing determinants have been critically approached and creatively discussed. In addition, key aspects and considerations of the HES-RES convergence are concluded.
Comparing the Simple to Complex Automatic Methods with the Ensemble Approach in Forecasting Electrical Time Series Data
Authors: Sulandari Winita , Yudhanto Yudho , Subanti Sri , Setiawan Crisma Devika , Hapsari Riskhia , Rodrigues Paulo Canas
Published: November 2023

The importance of forecasting in the energy sector as part of electrical power equipment maintenance encourages researchers to obtain accurate electrical forecasting models. This study investigates simple to complex automatic methods and proposes two weighted ensemble approaches. The automated methods are the autoregressive integrated moving average; the exponential smoothing error–trend–seasonal method; the double seasonal Holt–Winter method; the trigonometric Box–Cox transformation, autoregressive, error, trend, and seasonal model; Prophet and neural networks. All accommodate trend and seasonal patterns commonly found in monthly, daily, hourly, or half-hourly electricity data. In comparison, the proposed ensemble approaches combine linearly (EnL) or nonlinearly (EnNL) the forecasting values obtained from all the single automatic methods by considering each model component’s weight. In this work, four electrical time series with different characteristics are examined, to demonstrate the effectiveness and applicability of the proposed ensemble approach—the model performances are compared based on root mean square error (RMSE) and absolute percentage errors (MAPEs). The experimental results show that compared to the existing average weighted ensemble approach, the proposed nonlinear weighted ensemble approach successfully reduces the RMSE and MAPE of the testing data by between 28% and 82%.
Performance and Energy Utilization Efficiency of an Expanded Granular Sludge Bed Reactor in the Treatment of Cassava Alcohol Wastewater
Authors: Xu Guoqin , Ji Junlin , Zheng Zhanyao , Song Hongchuan , Yang Hong , Liu Jing , Yin Fang , Zhang Wudi , Hao Shumei
Published: November 2023

In recent years, expanded granular sludge blanket (EGSB) reactor has been widely used in the treatment of high-concentration organic wastewater, but its research mainly focused on treatment efficiency and microbial community composition. There were few studies on the relationship of operation conditions and energy utilization efficiency. Therefore, the methanogenic characteristics and energy utilization efficiency of EGSB reactor were studied by using cassava alcohol wastewater (CAW) as a raw material at (36 ± 1) °C. The results show that the degradation of volatile fatty acids (VFAs) is an important step affecting methane generation compared to the hydrolysis stage. When organic load rate (OLR) was 12.73 gCOD/L·d, the chemical oxygen demand (COD) removal rate was above 95%, the methane production efficiency of raw material was 202.73 mLCH4/ gCOD·d, the four-stage conversion efficiency was the highest, and the energy utilization efficiency was 62.26%, which was the optimal stage for EGSB reactor to treat CAW. These findings support high-efficiency bioenergy recovery from CAW in practice and highlight the potential wide application of high-performance anaerobic reactors for CAW.
Scaling Performance Parameters of Reciprocating Engines for Sustainable Energy System Optimization Modelling
Authors: Suijs Ward , Verhelst Sebastian
Published: November 2023

The increased share of variable renewable energy sources such as wind and solar power poses constraints on the stability of the grid and the security of supply due to the imbalance between electricity production and demand. Chemical storage or power-to-X technologies can provide the flexibility that is needed to overcome this issue. To quantify the needs of such storage systems, energy system optimization models (ESOMs) are used, guiding policy makers in nationwide energy planning. The key input parameters for such models are the capacity and efficiency values of the conversion devices. Gas turbines, reciprocating engines, fuel cells and Rankine engines are often mentioned here as cogeneration technologies. Their performance parameters will however need to be revised when switching from fossil to renewable fuels. This study therefore investigates the possibility of using size-based scaling laws to predict the efficiency and power values of one type of conversion technology: the reciprocating engine. The most straightforward scaling laws are the ones based on the fundamental engine performance parameters and are constructed by fitting an arithmetic function for a large set of representative engine data. Their accuracy was tested with a case study, consisting of thirty large-bore, spark-ignited gas engines. Two alternative methods were also investigated: scaling laws based on the Willans line method and scaling laws based on the similarity theory. Their use is deemed impractical for the current research problem.
Optimal Generation Dispatch in Electrical Microgrids Based on Inertia Markets as a Solution to Frequency Stability
Authors: Cruz Luis , Téllez Alexander Águila , Ortiz Leony
Published: November 2023

This paper addresses a crucial omission in the traditional approach to solving the classic economic dispatch problem within microgrids featuring renewable energy sources—the often-neglected frequency disturbances arising from reductions in system inertia. To remedy this, we present an innovative economic dispatch model empowered by nonlinear optimization (NLP), incorporating stringent minimum inertia constraints essential for ensuring system stability over a 24-h horizon. Our approach involves a comprehensive exploration of the intricate relationship between system inertia and frequency stability, culminating in the seamless integration of these inertia constraints into the economic dispatch model. To validate the practicality of our model, we present two distinct scenarios: a base case representing conventional dispatch methodologies and an alternative case that considers the imposition of inertia restrictions. These scenarios are rigorously tested and implemented using the CICGRE TF C6.04 test system. Employing the powerful GAMS platform alongside the NPL model, we successfully solved the dispatch problem. Our results underscore the significance of maintaining system inertia within the 1.54-s threshold proposed by our model, showcasing a tangible reduction in generation costs as a direct outcome of this enhanced approach to economic dispatch. This research advances the understanding of microgrid management and offers a practical solution to enhance system stability and economic efficiency in renewable-energy-powered microgrids.
Implementation Process Simulation and Performance Analysis for the Multi-Timescale Lookup-Table-Based Maximum Power Point Tracking under Variable Irregular Waves
Authors: Yue Xuhui , Meng Feifeng , Tong Zhoubo , Chen Qijuan , Geng Dazhou , Liu Jiaying
Published: November 2023

The efficacy of the multi-timescale lookup-table-based maximum power point tracking (MLTB MPPT) in capturing energy at various fixed sea states has already been demonstrated. However, it remains imperative to conduct a more comprehensive evaluation of the MPPT tracking performance under varying sea states in practical scenarios. Additionally, it is crucial to engage in an in-depth analysis of the dynamic process and energy loss/consumption associated with MLTB MPPT implementations. This paper focuses on the implementation process simulation and performance analysis for the MLTB MPPT under variable irregular waves. Firstly, the structure of the wave power controller based on a MLTB MPPT algorithm is described in detail, as well as that of a controlled plant, known as a novel inverse-pendulum wave energy converter (NIPWEC). Secondly, mathematical models for the MLTB MPPT are developed, taking into account the efficiency of each link. In this paper, we present simplified modelling methods for both permanent magnet synchronous generator (PMSG) vector control and permanent magnet synchronous motor (PMSM) servo control. Finally, the tracking performance of the MLTB MPPT in the presence of variable irregular waves is comprehensively analyzed by simulating the implementation process and comparing it with two other MPPT algorithms, i.e., the frequency- and amplitude-control-based MPPT and the lookup-table-based internal mass position adjustment combined with the optimal fixed damping search. Results show that the MLTB MPPT (Method 2) is a competitive algorithm. Besides, a significant portion (>12%) of the time-averaged absorbed power is actually lost during the power generation process. On the other hand, the power required for a mass-position-adjusting mechanism is relatively small (approximately 0.2 kW, <1.5%). The research findings can offer theoretical guidance for optimizing the operation of NIPWEC engineering prototypes under actual sea conditions.
Using Energy Policies to Shape Local Competitive Advantages
Authors: Grabowski Jakub , Ropęga Jarosław , Walecka Anna , Wiśniewska Marta
Published: November 2023

The aim of this study was to assess urban policies from the point of view of their impact on energy efficiency as a factor enhancing local competitiveness in Poland. To achieve this objective, we carried out an original study. The first step was to conduct a literature review. Next, an attempt was made to present the prevailing state of knowledge regarding the management of the competitiveness of cities and regions, as well as the functioning of energy efficiency in the economy. The development strategies of 18 selected cities serving as provincial capitals or playing other administrative roles at the regional level were also analysed. Importantly, the impact envisaged for municipal authorities to improve energy efficiency largely focuses on investments in the modernisation of public transport infrastructure and renewable energy sources. These investments certainly yield substantial cost savings, which are presented in the article. Nevertheless, it is essential to bear in mind that these are not the sole advantages of increased energy efficiency of local socio-economic systems. The investments also have the potential to enhance the perception of cities, increase the value of municipal real estate, and improve the health of urban residents by reducing emissions into the atmosphere. Still, a clearly discernible link between these arguments and a positive impact of cities’ energy savings on their competitive standing and competitive edge is absent from the analysed city development strategies.
Optimal Scheduling Strategy of Microgrid Based on Reactive Power Compensation of Electric Vehicles
Authors: Fang Yixiao , Yang Junjie , Jiang Wei
Published: November 2023

This paper proposes a microgrid optimal scheduling strategy based on the reactive power compensation of electric vehicles to address the issue of interactive fluctuation of voltage and power resulting from a high proportion of new energy integration into the grid. Firstly, for accurate prediction of electric vehicle charging and discharging behavior, the Monte Carlo simulation method was employed for day-ahead prediction. Secondly, an optimization method for reactive power compensation was developed, considering distributed sources such as wind turbines, photovoltaics, and electric vehicles, with the objective of minimizing network loss and power generation costs. Additionally, user-side prices and electric vehicle charging prices were taken into consideration. Finally, utilizing the IEEE14 bus simulation, a comparison was made between the microgrid with and without electric vehicle reactive support capacity. Results demonstrated that, while maintaining a power factor greater than 0.95, the proposed method reduced the average daily generation cost by 0.35%, average daily network loss by 7.0%, average daily bus voltage fluctuation by 48.60%, average electricity price by 2.88%, and EV user charging cost by 21.29%. These findings illustrate that the proposed reactive power compensation optimization method effectively mitigates voltage and power fluctuations resulting from new energy integration, ensuring system safety, reliability, and economic efficiency.
Influence of Magnetic Pole Stepping Combined with Auxiliary Stator Slots on the Stability of Dual-Rotor Disc Motors
Authors: Guo Tong , Cao Yang , Qian Zhong , Xia Jianping , Kang Xuhong , Xia Guanben , Yang Yanan , Zhang Wendong , Wang Yujie , Wu Guoqing
Published: November 2023

With the growing utilization of disc motors, the enhancement of their operational stability has become a critical research area. The existing studies usually focus on improving the pole structure of the rotor or the stator structure to optimize one performance of the motor and less on optimizing multiple performances. This paper simultaneously improves the rotor pole structure and stator tooth structure of the motor in order to optimize the sinusoidal waveform of the no-load back electromotive force and the cogging torque at the same time to achieve the goal of reducing the vibration and noise of the permanent-magnet synchronous dual-rotor statorless magnetically coupled disc motor and improve its operational stability. A finite element simulation model of a 20-pole, 24-slot permanent-magnet synchronous dual-rotor statorless magnetically coupled disc motor is established to analyze the influence of various factors, including the number of magnetic pole steps, the opening position, depth, and width of the stator auxiliary slot, on the motor performance. The results show that this stator–rotor combination improvement method effectively reduces the total harmonic distortion (THD) and attenuates multiple harmonics, and the peak cogging torque pulsation is significantly improved while other properties of the motor meet the technical requirements, and the motor performance is improved.
Biomass Amounts of Spontaneous Vegetation on Post-Coal Mine Novel Ecosystem in Relation to Biotic Parameters
Authors: Ryś Karolina , Chmura Damian , Prostański Dariusz , Woźniak Gabriela
Published: November 2023

The amounts of biomass in ecosystems depends on the efficiency of energy gathering in organic chemical bonds by autotrophs, which are the only organisms that synthesize inorganic compounds into organic compounds structured into biomass. Plant species composition in the vegetation patch and the associated microorganism communities are factors that affect the matter and energy flow in the ecosystem. In human-established or severely transformed novel ecosystems, in particular in mineral-poor, oligotrophic habitats, the knowledge about the biotic parameters related to the biomass amount is very limited. The presented studies were performed on post-black coal mining heaps that provide the mineral material habitat. The following biotic parameters, the vegetation plant species composition of the distinguished vegetation types, soil organic matter, soil enzymatic activity, soil fauna presence, and the functional aspect of soil carbon release concerning amount of biomass are considered. The aim of this research was to analyze the influence of the selected biotic factors on the biomass amount in the vegetation patches of the studied sites. The results showed that the effect of the species composition diversity on the biomass amount is complex. The influences of soil enzyme activity on biomass amount are dependent on the enzyme presence and the vegetation type. Similarly, the impact of the soil organic matter (SOM) on the biomass amount is significantly different and dependent on vegetation type. The relationship between the amount of biomass and respiration showed that the biomass of the dominant plant species is positively correlated with the biomass amount in the studied vegetation types.
Effects of Aromatic Compounds Degradation on Bacterial Cell Morphology
Authors: Gerginova Maria , Spankulova Gulzhan , Paunova-Krasteva Tsvetelina , Peneva Nadejda , Stoitsova Stoyanka , Alexieva Zlatka
Published: November 2023

The aim of the present study was to evaluate in parallel the capacity of three bacterial strains originating from oil-polluted soils to degrade monoaromatic compounds and the alterations in the bacterial cell morphology as a result of the biodegradation. The strain Gordonia sp. 12/5 can grow well in media containing catechol, o-, m-, and p-cresol without significant morphological changes in the cells, as shown by scanning electron microscopy. This implies good adaptation of the strain for growth in hydrocarbon-containing media and indicates it is a proper candidate strain for further development of purification methodologies applicable to ecosystems contaminated with such compounds. The growth of the two Rhodococcus strains in the presence of the above carbon sources is accompanied by changes in cell size characteristic of stress conditions. Nevertheless, their hydrocarbon-degrading capacity should not be neglected for future applications. In summary, the established ability to degrade monoaromatic compounds, in parallel with the morphological changes of the bacterial cells, can be used as a valuable indicator of the strain’s vitality in the presence of tested aromatic compounds and, accordingly, of its applicability for bioremediation purposes.
The Fractional Soliton Wave Propagation of Non-Linear Volatility and Option Pricing Systems with a Sensitive Demonstration
Authors: Riaz Muhammad Bilal , Ansari Ali Raza , Jhangeer Adil , Imran Muddassar , Chan Choon Kit
Published: November 2023

In this study, we explore a fractional non-linear coupled option pricing and volatility system. The model under consideration can be viewed as a fractional non-linear coupled wave alternative to the Black–Scholes option pricing governing system, introducing a leveraging effect where stock volatility corresponds to stock returns. Employing the inverse scattering transformation, we find that the Cauchy problem for this model is insolvable. Consequently, we utilize the Φ6-expansion algorithm to generate generalized novel solitonic analytical wave structures within the system. We present graphical representations in contour, 3D, and 2D formats to illustrate how the system’s behavior responds to the propagation of pulses, enabling us to predict suitable parameter values that align with the data. Finally, a conclusion is given.
Voices of Musicians: Virtual Live Bedside Music Concerts in Inpatient Care
Authors: Ambler Melanie , Janss Andrew , Stafford Randall S. , Lin Bryant , Florom-Smith Aubrey , Kang Augustine W.
Published: November 2023

The COVID-19 pandemic presented unprecedented challenges to patients, family members, and healthcare staff that resulted in increased stress and isolation and decreased quality of life. We evaluate the impact of a novel virtual concert program, the Vital Sounds Initiative (VSI) of Project: Music Heals Us (PMHU), which began at the beginning of the pandemic to combat patient isolation and provide employment to professional musicians. Using a qualitative analysis of VSI data, we examined post-concert written responses by musicians. These responses were coded by independent coders via inductive coding and thematic analysis. Between 7 April 2020 and 20 July 2022, 192 musicians played 2203 h of music for 11,222 audience members in 39 care facilities nationwide. A total of 114 musicians submitted a total of 658 responses. Three main themes (with corresponding subthemes) arose: (1) Patient Experience; (2) Musician Experience; (3) Caregiver (family or staff) Experience. The responses offered valuable insight into the overwhelmingly positive aspects of the virtual concerts. Overall, we found that VSI favorably impacts individuals at every level, including the patients, musician, and caregivers. These findings provide preliminary evidence for the benefits of virtual music concerts. Upscaling similar virtual music interventions/programs should be considered.
Effect of Hind- and Fore-Foot Eversion on Positional and Rotational Displacement of the Knee in Standing Posture
Authors: Kim Jae Yi , Park So Yeong , Lee Do Yeon , Jeong Seong Hoon , Kim Il Soo , Lim Seong Hoon
Published: November 2023

We investigated the effects of hindfoot and forefoot eversion on the knee’s positional and rotational displacement, plantar pressure, and foot discomfort in a standing posture, beyond the traditional focus on external knee adduction moments (EKAM) in lateral wedge insoles. Twenty-six healthy participants underwent hindfoot eversion from 0 to 10 degrees in 2-degree increments, and forefoot eversion from 0 degrees to the hindfoot eversion angle in 2-degree increments in a standing posture. At each eversion angle, the knee’s medial displacement, EKAM’s moment arm decrease, plantar pressure changes, and foot discomfort were obtained and compared across varying angles. Both hindfoot-only and entire-foot eversion led to significant medial knee displacement and the EKAM’s moment arm decrease, with more pronounced effects in entire-foot eversion. At each hindfoot eversion angle, increasing forefoot eversion resulted in significant medial knee displacement and EKAM’s moment arm decrease. Lower leg rotations were not significantly affected in hindfoot-only eversion but displayed significant medial tilting and internal rotation in entire-foot eversion at specific combinations. Varying eversion angles significantly influenced the forefoot pressure, with heel pressure remaining unaffected. Notably, the lateral forefoot pressure increased significantly as the forefoot eversion angle increased, particularly at higher hindfoot eversion angles. Foot discomfort increased significantly with higher eversion angles, particularly in entire-foot eversion, and also increased significantly as the forefoot eversion angle increased at higher hindfoot eversion angles. Insole configurations incorporating 6–10 degrees of hindfoot eversion and 40–60% forefoot eversion of the hindfoot angle may offer optimized biomechanical support for knee osteoarthritis patients.
The Challenge of Weight Stigma for Women in the Preconception Period: Workshop Recommendations for Action from the 5th European Conference on Preconception Health and Care
Authors: Hill Briony , Azzari Wynn-Jones Alexandra , Botting Kimberley J. , Cassinelli Emma H. , Daly Michael P. , Gardiner Caitlin Victoria , Hanley Stephanie J. , Heslehurst Nicola , Steegers-Theunissen Regine , Verbiest Sarah , Skouteris Helen
Published: November 2023

Weight stigma is a well-recognised public health issue affecting many members of society including women during the preconception period. The impacts of preconception weight stigma on women are significant and may result in decreased access to and uptake of healthcare, and mental health concerns. The consequences of this weight stigma may translate to negative maternal outcomes and even intergenerational effects on the child. Eliminating weight stigma is therefore imperative. The aim of this paper is to report recommendations to reduce weight stigma for preconception women produced at a workshop with clinical and academic experts on preconception health and weight stigma at the 5th European Conference on Preconception Health and Care. The recommendations are related to two key areas: general societal recommendations prompting all people to acknowledge and adjust our attitudes towards larger-bodied people; and healthcare-specific recommendations imploring clinicians to upskill themselves to reduce weight stigma in practice. We therefore call for urgent approaches to address societal weight-stigmatising attitudes and norms related to both the general population and preconception women, while providing professional development opportunities for healthcare professionals relating to weight stigma. Eliminating weight stigma for preconception women may have positive impacts on the outcomes for mothers and children during pregnancy and beyond.
Suitability of the Attitudes to Aging Questionnaire Short Form for Use among Adults in Their 50s: A Cross-Sectional e-Survey Study
Authors: Low Gail , França Alex Bacadini , Wilson Donna M. , Gutman Gloria , von Humboldt Sofia
Published: November 2023

This cross-sectional e-survey study examines the suitability (reliability and validity) of the 12-item Attitudes to Aging Questionnaire Short Form (AAQ-SF) for use among adults in their 50s. The AAQ-SF instrument was originally designed to capture subjective perceptions of physical change, psychosocial loss, and psychological growth by asking people aged 60 and beyond how they feel about growing older. Our sample comprised 517 people residing in three Canadian provinces. Respondents completed the Attitudes to Aging Questionnaire Short Form, the Rosenberg Self-Esteem Scale, and a short sociodemographic profile. Our findings replicate the original AAQ-SF structure for physical change, psychosocial loss, and psychological growth, with a promising internal consistency range for the third subscale. In our sample, psychological growth is best represented as ‘Self’ and ‘Generativity’, with a particularly greater capacity to explain variations in scores for item 18 and item 21. Physical change and psychosocial loss scores strongly differed based on perceived health and chronic illness presence. Psychosocial loss and psychological growth were moderately correlated with two aspects of self-esteem. We relate these patterns of findings within the context of prevailing growth and development theory and their perceived implications within the context of COVID-19 and post-pandemic life.
Unlocking the WHO’s Age-Friendly Healthcare Principles: Portugal’s Quest and Recommendations
Authors: Tavares Jéssica , Santinha Gonçalo , Rocha Nelson Pacheco
Published: November 2023

Countries worldwide are grappling with a pressing demographic challenge characterized by a growing older population. This poses a significant healthcare dilemma, presenting challenges for healthcare systems and providers. To address these challenges, the World Health Organization (WHO) has devised a set of Age-Friendly Principles, aimed at optimizing healthcare provision for older people. This article delves into the current state of healthcare adaptation for older adults in Portugal and assesses the implementation of the WHO Principles. Case studies were conducted in three distinct regions of Portugal, involving semistructured interviews with key decision makers from both the healthcare sector and organizations wielding direct influence over health policies (n = 11). A comprehensive content analysis was conducted employing the webQDA software. The findings unveiled a noteworthy trend in which most interviewees displayed limited familiarity with the WHO Principles. Nevertheless, all interviewees acknowledged the need to adapt the healthcare system accordingly. Strengths were identified, primarily within the healthcare management system, but noteworthy gaps were also revealed, particularly in terms of facility preparedness and professional training. Interviewees proposed various interventions to enhance age-friendly healthcare provision; however, they concurrently pinpointed challenges related to human resources, infrastructure, and financial management. In their concluding recommendations, interviewees underscored the development of tools to facilitate the application and evaluation of the WHO Principles, as well as the development by the WHO of an accreditation system to encourage the application of the principles in healthcare providers across the world.
Willingness to Pay for COVID-19 Vaccines in Japan
Authors: Yoda Takeshi , Iwasaki Nagisa , Katsuyama Hironobu
Published: November 2023

More than 80% of the Japanese population had received the coronavirus disease 2019 (COVID-19) vaccination by the end of April 2023; however, this vaccination rate continues to decline along with the need for booster shots. Further, the vaccines may not permanently be available free of charge. This study conducted a survey to determine the public’s willingness to pay for the COVID-19 vaccine in Japan. Using an internet research panel, the questionnaire collected data on various sociodemographic variables and the respondents’ willingness to pay for COVID-19 vaccines. Descriptive statistics and logistic regression analysis were used to evaluate the respondents’ answers. The results showed that of 1100 respondents, 55.2% would not want to receive the vaccine if it was paid for. A total of 44.8% respondents expressed willingness to pay, with most (170 respondents) willing to pay for 1000–1999 JPY (7.1–14.2 USD). Logistic regression analysis revealed that age, educational status, history of contracting COVID-19, and COVID-19 vaccination frequency were significantly associated with those who were willing to receive the COVID-19 vaccine if it was free (p < 0.05). These findings provide valuable insights for the Japanese government in determining appropriate pricing strategies to promote COVID-19 vaccination effectively.
StBIN2 Positively Regulates Potato Formation through Hormone and Sugar Signaling
Authors: Liu Jie , Cai Chengcheng , Liu Shifeng , Li Liqin , Wang Qiang , Wang Xiyao
Published: November 2023

Potato is an important food crop worldwide. Brassinosteroids (BRs) are widely involved in plant growth and development, and BIN2 (brassinosteroid insensitive 2) is the negative regulator of their signal transduction. However, the function of BIN2 in the formation of potato tubers remains unclear. In this study, transgenic methods were used to regulate the expression level of StBIN2 in plants, and tuber related phenotypes were analyzed. The overexpression of StBIN2 significantly increased the number of potatoes formed per plant and the weight of potatoes in transgenic plants. In order to further explore the effect of StBIN2 on the formation of potato tubers, this study analyzed BRs, ABA hormone signal transduction, sucrose starch synthase activity, the expression levels of related genes, and interacting proteins. The results show that the overexpression of StBIN2 enhanced the downstream transmission of ABA signals. At the same time, the enzyme activity of the sugar transporter and the expression of synthetic genes were increased in potato plants overexpressing StBIN2, which also demonstrated the upregulation of sucrose and the expression of the starch synthesis gene. Apparently, StBIN2 affected the conversion and utilization of key substances such as glucose, sucrose, and starch in the process of potato formation so as to provide a material basis and energy preparation for forming potatoes. In addition, StBIN2 also promoted the expression of the tuber formation factors StSP6A and StS6K. Altogether, this investigation enriches the study on the mechanism through which StBIN2 regulates potato tuber formation and provides a theoretical basis for achieving a high and stable yield of potato.
The Identification of a Quantative Trait Loci-Allele System of Antixenosis against the Common Cutworm (Spodoptera litura Fabricius) at the Seedling Stage in the Chinese Soybean Landrace Population
Authors: Pan Lin , Gai Junyi , Xing Guangnan
Published: November 2023

Common cutworm (CCW) is an omnivorous insect causing severe yield losses in soybean crops. The seedling-stage mini-tray identification system with the damaged leaf percentage (DLP) as an indicator was used to evaluate antixenosis against CCW in the Chinese soybean landrace population (CSLRP) under three environments. Using the innovative restricted two-stage multi-locus genome-wide association study procedure (RTM-GWAS), 86 DLP QTLs with 243 alleles (2–11/QTL) were identified, including 66 main-effect loci with 203 alleles and 57 QTL-environment interaction loci with 172 alleles. Among the main-effect loci, 12 large-contribution loci (R2 ≥ 1%) explained 25.45% of the phenotypic variation (PV), and 54 small-contribution loci (R2 < 1%) explained 16.55% of the PV. This indicates that the CSLRP can be characterized with a DLP QTL-allele system complex that has not been found before, except for a few individual QTLs without alleles involved. From the DLP QTL-allele matrix, the recombination potentials expressed in the 25th percentile of the DLP of all possible crosses were predicted to be reduced by 41.5% as the maximum improvement and 14.2% as the maximum transgression, indicating great breeding potential in the antixenosis of the CSLRP. From the QTLs, 62 candidate genes were annotated, which were involved in eight biological function categories as a gene network of the DLP. Changing from susceptible to moderate plus resistant varieties in the CSLRP, 26 QTLs had 32 alleles involved, in which 19 genes were annotated from 25 QTL-alleles, including eight increased negative alleles on seven loci and 11 decreased positive alleles on 11 loci, showing the major genetic constitution changes for the antixenosis enhancement at the seedling stage in the CSLRP.
B Cells Induce Early-Onset Maternal Inflammation to Protect against LPS-Induced Fetal Rejection
Authors: Uehre Gina Marie , Tchaikovski Svetlana , Ignatov Atanas , Zenclussen Ana Claudia , Busse Mandy
Published: November 2023

The maternal balance between B regulatory (Breg) cells and inflammatory B cells is of central importance for protection against preterm birth (PTB). However, the impact of B cell signaling in early maternal and fetal immune responses on inflammatory insults remains underinvestigated. To understand which role B cells and B-cell-specific signaling play in the pathogenesis of PTB, the later was induced by an injection of LPS in B cell-sufficient WT mice, CD19−/−, BMyD88−/− and µMT murine dams at gestational day 16 (gd 16). WT dams developed a strong inflammatory response in their peritoneal cavity (PC), with an increased infiltration of granulocytes and enhanced IL-6, TNF-α, IL-17 and MCP-1 levels. However, they demonstrated a reduced NOS2 expression of PC macrophages 4 h after the LPS injection. Simultaneously, LPS-challenged WT dams upregulated pregnancy-protective factors like IL-10 and TARC. The concentrations of inflammatory mediators in the placental supernatants, amniotic fluids, fetal serums and gestational tissues were lower in LPS-challenged WT dams compared to CD19−/−, BMyD88−/− and µMT dams, thereby protecting WT fetuses from being born preterm. B cell deficiency, or the loss of B-cell-specific CD19 or MyD88 expression, resulted in an early shift from immune regulation towards inflammation at the fetomaternal interface and fetuses, resulting in PTB.
Effect of SARS-CoV-2 Infection and BNT162b2 Vaccination on the mRNA Expression of Genes Associated with Angiogenesis
Authors: Wigner-Jeziorska Paulina , Janik-Karpińska Edyta , Niwald Marta , Saluk Joanna , Miller Elżbieta
Published: November 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovered in December 2019 in Wuhan, China, caused the coronavirus disease 2019 (COVID-19). Due to the rate of spread of this virus, the World Health Organization, in March 2020, recognised COVID-19 as a worldwide pandemic. The disease is multisystemic with varying degrees of severity. Unfortunately, despite intensive research, the molecular changes caused by SARS-CoV-2 remain unclear. Mechanisms affected by the virus infection include endothelial dysfunction and angiogenesis. Similarly, the vaccines developed so far affect the process of angiogenesis, contributing to the development of undesirable effects on part of the cardiovascular system. The presented research aimed to investigate the impact of the SARS-CoV-2 infection and the Pfizer Comirnaty vaccine (BNT162b2) on the molecular aspect of angiogenesis. We found that convalescents vaccinated with one dose of BNT162b2 were characterised by higher MMP-7 (metalloproteinases 7) expression than non-vaccinated convalescents and healthy volunteers vaccinated with one dose of BNT162b2. Moreover, non-vaccinated convalescents showed increased mRNA expression of ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1) compared to healthy volunteers vaccinated with one dose of BNT162b2. In addition, we showed significant sex differences in the expression of MMP-7. In conclusion, the results of our study suggest a significant impact of SARS-CoV-2 infection and vaccination on the course of angiogenesis at the molecular level.
A Strategy Utilizing Protein–Protein Interaction Hubs for the Treatment of Cancer Diseases
Authors: Carels Nicolas , Sgariglia Domenico , Junior Marcos Guilherme Vieira , Lima Carlyle Ribeiro , Carneiro Flávia Raquel Gonçalves , Silva Gilberto Ferreira da , Silva Fabricio Alves Barbosa da , Scardini Rafaela , Tuszynski Jack Adam , Andrade Cecilia Vianna de , Monteiro Ana Carolina , Martins Marcel Guimarães , Silva Talita Goulart da , Ferraz Helen , Finotelli Priscilla Vanessa , Balbino Tiago Albertini , Pinto José Carlos
Published: November 2023

We describe a strategy for the development of a rational approach of neoplastic disease therapy based on the demonstration that scale-free networks are susceptible to specific attacks directed against its connective hubs. This strategy involves the (i) selection of up-regulated hubs of connectivity in the tumors interactome, (ii) drug repurposing of these hubs, (iii) RNA silencing of non-druggable hubs, (iv) in vitro hub validation, (v) tumor-on-a-chip, (vi) in vivo validation, and (vii) clinical trial. Hubs are protein targets that are assessed as targets for rational therapy of cancer in the context of personalized oncology. We confirmed the existence of a negative correlation between malignant cell aggressivity and the target number needed for specific drugs or RNA interference (RNAi) to maximize the benefit to the patient’s overall survival. Interestingly, we found that some additional proteins not generally targeted by drug treatments might justify the addition of inhibitors designed against them in order to improve therapeutic outcomes. However, many proteins are not druggable, or the available pharmacopeia for these targets is limited, which justifies a therapy based on encapsulated RNAi.
Current Medical Therapy and Revascularization in Peripheral Artery Disease of the Lower Limbs: Impacts on Subclinical Chronic Inflammation
Authors: Cecchini Andrea Leonardo , Biscetti Federico , Manzato Matteo , Lo Sasso Lorenzo , Rando Maria Margherita , Nicolazzi Maria Anna , Rossini Enrica , Eraso Luis H. , Dimuzio Paul J. , Massetti Massimo , Gasbarrini Antonio , Flex Andrea
Published: November 2023

Peripheral artery disease (PAD), coronary artery disease (CAD), and cerebrovascular disease (CeVD) are characterized by atherosclerosis and inflammation as their underlying mechanisms. This paper aims to conduct a literature review on pharmacotherapy for PAD, specifically focusing on how different drug classes target pro-inflammatory pathways. The goal is to enhance the choice of therapeutic plans by considering their impact on the chronic subclinical inflammation that is associated with PAD development and progression. We conducted a comprehensive review of currently published original articles, narratives, systematic reviews, and meta-analyses. The aim was to explore the relationship between PAD and inflammation and evaluate the influence of current pharmacological and nonpharmacological interventions on the underlying chronic subclinical inflammation. Our findings indicate that the existing treatments have added anti-inflammatory properties that can potentially delay or prevent PAD progression and improve outcomes, independent of their effects on traditional risk factors. Although inflammation-targeted therapy in PAD shows promising potential, its benefits have not been definitively proven yet. However, it is crucial not to overlook the pleiotropic properties of the currently available treatments, as they may provide valuable insights for therapeutic strategies. Further studies focusing on the anti-inflammatory and immunomodulatory effects of these treatments could enhance our understanding of the mechanisms contributing to the residual risk in PAD and pave the way for the development of novel therapies.