bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Effect of AAV8-Mediated miR-23a in Immobilization-Induced Muscle Atrophy in Mice
Authors: Lu Na  , Yijin Wang , Wenxin  , Jumuddin Farra Aidah
Published: August 2024

bjective: To investigate the therapeutic effect of miR-23a in immobilization-induced muscle atrophy in mice. Methods: (Experiment 1) Twelve C57BL6 wild-type mice were randomly divided into two groups: Sham group (sham surgery) and Immobilization (hind limb immobilization surgery). Fluorescence quantitative PCR was performed to detect the expression changes of miR-23a, MuRF-1, and Atrogin-1 7 days post-surgery. (Experiment 2) Twelve C57BL6 wild-type mice were randomly divided into 4 groups according to surgery type (sham surgery and hind limb immobilization surgery) and injection type (AAV8 or AAV8-OEmiR-23a), fluorescence quantitative PCR to detect changes in MuRF-1 and Atrogin-1 expression in mouse gastrocnemius muscle. (Experiment 3) NFATc3 expression changes were detected by fluorescence quantitative PCR 48 hours post-transfection. (Experiment 4) Twelve C57BL6 wild-type mice underwent hind limb immobilization surgery, divided into 4 groups : Immobilization+AAV8-control, Immobilization+AAV8-OEmiR23a, Immobilization+AAV8-shNFATc3, and Immobilization+AAV8-OEmiR-23a+AAV8-shNFATc3. quantitative PCR to detect changes in MuRF-1 and Atrogin-1 expression in mouse gastrocnemius muscle. Results: Fluorescence quantitative PCR results showed that miR-23a was downregulated in immobilization-induced muscle atrophy, while MuRF-1 and Atrogin-1 expression was upregulated. WGA staining results showed that intramuscular injection of AAV8-OEmiR-23a could significantly alleviate the decrease in muscle fiber cross-sectional area and the increase in expression of muscle atrophy marker genes MuRF-1 and Atrogin-1 caused by hind limb immobilization, Fluorescence quantitative PCR revealed that when miR-23a expression was inhibited, NFATc3 expression was downregulated; when miR-23a was overexpressed, NFATc3 expression was upregulated, Fluorescence quantitative PCR results showed that intramuscular injection of AAV8-OEmiR-23a and AAV8-shNFATc3 could not alleviate the increase in expression of muscle atrophy marker genes MuRF-1 and Atrogin-1 caused by hind limb immobilization. Conclusion: miR-23a can treat hind limb immobilization-induced muscle atrophy in mice.
Mother Cultures
Authors: Hafstein Valdimar Tr. , Þór Pétursson Jón , Þór Marteinsson Viggó
Published: August 2024

This article explores long-standing symbiotic relations between women and microbes in Iceland while analysing the transformation of this relationship in the making of the dairy product skyr during the twentieth and twenty-first centuries. In the past, differences in microbial cultures and production methods meant that the taste and texture of skyr varied greatly. Standardisation and technological innovations have steadily impoverished its microbial diversity over the past 120 years. Starting from a historical account of skyr making, we zoom in on skyr in the twenty-first century, a period in which skyr has had an international breakthrough, captured in branding efforts and advertising campaigns produced in this decade for various types of skyr from producers in Iceland, Europe and the United States.
Extent of resection and progression-free survival in vestibular schwannoma: a volumetric analysis
Authors: Nandoliya Khizar R. , Khazanchi Rushmin , Winterhalter Emily J. , Youngblood Mark W. , Karras Constantine L. , Jain Rishi , Sonabend Adam M. , Chandler James P. , Magill Stephen T.
Published: August 2024

OBJECTIVE

To preserve facial nerve function in vestibular schwannoma (VS) microsurgery, some have advocated subtotal resection (STR) if the tumor is densely adherent to a thinned facial nerve. The objective of this study was to determine if residual volume is associated with progression and whether there is a threshold residual volume that should be pursued during STR to prevent recurrence. A secondary objective of this study was to determine whether facial nerve function at last follow-up was associated with extent of resection (EOR).

METHODS

Clinical and radiographic data were retrospectively collected from the records of 164 patients with VS who underwent resection. Tumor volumes were measured using Visage, and standard statistical methods were used. The House-Brackmann scale was used to assess changes in facial nerve function before surgery and at last follow-up.

RESULTS

Sixty-one patients (37%) received gross-total resection (GTR) and 103 (63%) received STR. The median clinical and radiographic follow-ups were 49 and 48 months, respectively. The median residual volume was 0.5 cm3 after STR. Kaplan-Meier actuarial survival analysis revealed a 96.3% 5-year progression-free survival (PFS) rate after GTR, which was greater than that after STR (84.5%, p = 0.03). Recursive partitioning analysis of patients receiving STR revealed a residual volume of 0.60 cm3 as the optimal threshold for recurrence. Patients with residual volume ≥ 0.60 cm3 had a 76.0% 5-year PFS, regardless of adjuvant SRS, which was lower than that for patients undergoing GTR (96.3%) or STR (95.6%) with residual volumes < 0.60 cm3 (p < 0.01). On Cox regression analysis, residual volume ≥ 0.60 cm3 (HR 14.4, p = 0.01) was independently associated with progression, even when accounting for patient age, adjuvant radiosurgery, and preoperative tumor size. In 112 patients with at least 24 months of follow-up after their last treatment, tumor control was achieved in 111 (99.1%) patients at a median last follow-up of 71 months. Worse facial nerve function at the last follow-up was independently associated with prior treatment for VS (adjusted OR 3.7, p = 0.04), but not residual volume cohort or preoperative tumor volume.

CONCLUSIONS

Residual volume > 0.60 cm3 after VS resection was independently associated with tumor progression, even accounting for adjuvant SRS. These data support maximizing the EOR during VS surgery, even if GTR cannot be safely achieved.
Historical Experience of Realizing the Duty of Church Care for Orphans
Authors: Седельников Никита
Published: August 2024

Данная статья посвящена обзору христианского опыта попечения о детях сиротах. Ко времени зарождения первых христианских общин проблема сиротства беспокоила человечество. Необходимость помощи сиротам, как религиозного долга, прослеживается уже в книгах Ветхого Завета. Христиане также осознавали своим долгом заботу о сиротах, в разное время отдавая приоритет тем или иным её формам.

This article is devoted to an overview of the Christian experience of caring for orphans. By the time of the first Christian communities, the problem of orphanhood was of concern to mankind. The need to help orphans as a religious duty can be traced back to the books of the Old Testament. Christians also recognized their duty to care for orphans, at different times giving priority to one or another form of care.
Identifikasi Pola Pemukiman Dan Saluran Pemasaran Pertanian Komoditi Hortikultura Di Kecamatan Suliki
Authors: Sepriyanti Burano Rizqha , Hani Putri  , Teguh Haria Aditia Putra
Published: August 2024

Pola permukiman yang ada di pedesaan akan mempengaruhi bagaimana distribusi hasil pertanian dilakukan. Pola permukiman yang efisien dan strategis dapat mempengaruhi aksesibilitas petani atau produsen ke pasar.Penelitian ini bertujuan untuk mengetahui pola permukiman di Kecamatan Suliki dan mengetahui hubungan pola permukiman dengan saluran pemasaran di Kecamatan Suliki. Penelitian ini dilaksanakan dari bulan Juni sampai bulan Juli tahun 2023. Penelitian ini merupakan penelitian deskriptif kuantitatif. Penelitian ini dilakukan dengan menggunakan teknik analisis tetangga terdekat (nearest neighbor analysis) dan regresi linier. Jenis data yang digunakan dalam penelitian ini adalah data primer dan sekunder. Ini merupakan penelitian pertama yang dilakukan di Indonesia untuk membuktikan bahwa terdapat hubungan antara pola permukiman dan keputusan petani menentukan saluran pemasaran. Pada penelitian terdahulu disebutkan bahwa Keputusan petani memilih saluran pemasaran dipengaruhi berbagai faktor seperti jarak ke pasar dan aksesibilitas. Dua hal tersebut secara tidak langsung terbentuk karena pola permukiman penduduk. Namun belum ada yang secara jelas menyatakan tentang hubungan pola permukiman dan saluran pemasaran. Sementara pada penelitian Wang (2021) disebutkan bahwa perubahan pola permukiman terjadi karena pengaruh beberapa faktor, salah satu faktor tersebut adalah sistem pemasaran hasil pertanian. Saluran pemasaran merupakan bagian dari sistem pemasaran tersebut. Jadi hipotesis awal dari penelitian ini adalah terdapat hubungan antara pola permukiman dan saluran pemasaran. Dari hasil penelitian ini diketahui pola permukiman di Kecamatan Suliki beragam, yaitu dua nagari berpola mengelompok, tiga nagari berpola acak, dan satu nagari berpola seragam. Hasil penelitian ini juga membuktikan kebenaran dari hipotesis awal bahwa pola permukiman mempunyai hubungan dengan saluran pemasaran. Ini artinya pola permukiman mempengaruhi petani dalam memilih saluran pemasaran.
The dialogue of theology and law in russian science and education
Authors: Gryanova Elena V.
Published: August 2024

Theology in Russian education is increasingly strengthening its position, claiming interdisciplinary status. Such areas as theological anthropology, theological psychology, legal and political theology, etc. are being developed. The spread of theology in secular universities of the country faces a number of difficulties related to the specifics of integrating secular and religious education and science. A special point of intersection is the dialogue of law and theology on the basis of secular universities. The author of the article analyzes the possibility and relevance at the present stage of the transition from the historical dialogue of these two main regulators of public life and types of knowledge to the development and implementation of specific educational programs for training lawyers and jurists based not only on legal but also theological knowledge, taking into account the current political and legal situation in Russia and the world. It is especially important to take into account the specifics of the Russian Orthodox culture with its rich experience of spiritual and educational practice and positive foreign experience of integrating theology and law in the educational system.
Case Report: Babesiosis Presenting to the Emergency Department
Authors: Zaayenga Daniel M. , Weeks Daniel A.
Published: August 2024

Babesiosis is a tick-borne illness caused by the parasitic protozoa Babesia transmitted by the Ixodes tick. Babesia infect the red blood cell of its host and requires the cell for its replication. It is a disease process that can range from asymptomatic infection to organ failure and death. This case presentation reviews a 68-year-old male who presented to the emergency department with flu like symptoms and was found to have babesiosis.
The Perception of Nurse Case Care Managers About the Needs of Cancer Patients
Authors: Artioli Giovanna , Foà Chiara , Manfrini Gisele Cristina , Camacho Victoria Cervantes , Taffurelli Chiara
Published: August 2024

_Background and aim. _Several studies in the literature state that cancer patients show unmet needs despite standard care. The aim of the study was to understand the perceptions of oncology case care managers regarding the met or unmet needs of patients and relatives.

_Methods _The study used a qualitative approach through a semi-structured interview. Twenty Case Care Manager (CCM) nurse practitioners performing their function in four AUSLs in Northern, Central-Northern and Central Italy were recruited and selected on a convenience criterion. The study ran from April 2021 to February 2022.

_Results:_ It emerges that numerous needs are not always met and that dysfunctionally affects the quality of life of cancer patients. These include information, emotional, psychological and social needs. Feelings of fear, distress, anxiety and depression often accompany them. These are complex needs which are difficult to answer. Case care managers have shown themselves to be able to recognise the needs. These findings underscore the urgent need to recognise and address the complex needs of cancer patients and their relatives. This study serves as a call to action, urging the healthcare community to strive for comprehensive solutions to these pressing issues.

_Conclusion:_ CCMs, being a stable reference point for patients and their families, acknowledge that they create a relationship of trust with patients, with a positive impact on their quality of life.
Citizenship Education in the Era of Society 5.0 with the Strengthening of anti-State Attitudes for Elementary School Students
Authors: Aprita Ning , Akhiroh Mazroatul , Muslim Septika Ayumicahya , Nurlaila Evi
Published: August 2024

The abundance of information circulating in the media has raised concerns among the students in the use of society 5.0 era technology to strengthen a state-of-the-art attitude. This literature review aims to utilize technology in the era of society to strengthen the attitude of defending the country in elementary school students in citizenship education. Citizenship Education (PKn) in the Society 5.0 era is the main focus in preparing elementary school students for life in the modern era based on literature such as books, journals, articles and official documents related to the Independent Curriculum. Civics in this era emphasizes the use of digital technology and artificial intelligence to develop creativity, critical thinking skills and innovation. Therefore, appropriate strategies are needed to utilize technology to instill an attitude of defending the country in students. The literature method is used to analyze various sources related to Civics, Society 5.0, and national defense. The results of the analysis show that the Merdeka Curriculum can be an innovation in responding to the challenges of Civics in the Society 5.0 era. It is hoped that this research can contribute to the development of effective Civics learning strategies in the Society 5.0 era, so that it can foster a sense of nationalism and patriotism in students.
Selbstmelder*innen in der Inobhutnahme – Hürden auf dem Weg in Hilfen
Authors: Franzheld Tobias , Neubert Carolin
Published: August 2024

Selbstmeldungen sind eine durch Einrichtungen der Kinder- und Jugendhilfe geschützte, aber dennoch in Teilen für die betroffenen Jugendlichen schwierige Mitteilungspraxis. Der Beitrag stellt erste Ergebnisse eines Forschungsprojekts zu diesem Thema vor, dessen Grundlage bisher 15 Interviews mit „Selbstmelder*innen“ sind. Er bezieht sich dabei auf eine Falldarstellung (Hannah), die die Hürden der Selbstmeldung verdeutlicht.
Erzieherische Hilfen in Deutschland als Vorbild für Neuerungen der englischen Kinderund Jugendhilfe? Eindrücke zum Besuch englischer Parlamentarier*innen in Berlin
Authors: Knuth Nicole , Köngeter Stefan , Krause Hans-Ullrich , Strahl Benjamin
Published: August 2024

Internationales: Erzieherische Hilfen in Deutschland als Vorbild für Neuerungen der englischen Kinderund Jugendhilfe? Eindrücke zum Besuch englischer Parlamentarier*innen in Berlin
Beraten. Qualifizieren. Validieren. Die Rolle der Erwachsenenbildung / Weiterbildung in der Fachkräftesicherung
Authors:   Deutsches Institut für Erwachsenenbildung (DIE), Strauch Anne
Published: August 2024

Anerkennung und Validierung von bestehenden Kompetenzen sowie die Qualifizierung und Weiterentwicklung von berufsrelevanten Fähigkeiten und Fertigkeiten sind bei der Bewältigung des Fachkräftemangels von großer Bedeutung. Die Autorin lotet die zentrale Stellung von Weiterbildungen aus und betont, dass die effektive Verzahnung von Beratungs-, Anerkennungs- und Validierungsinfrastrukturen ein wichtiges Mittel in der Fachkräftegewinnung und -sicherung ist.
ORGANIZATIONAL AND ECONOMIC MECHANISM OF THE FUNCTIONING OF TOURISM AND HOSPITALITY ENTITIES IN THE CONDITIONS OF SYSTEMIC CRISES
Authors:   State University of Trade and Economics, Okhrimenko Alla , Opanasiuk Nataliia ,   National University of Physical Education and Sport of Ukraine, Kulyk Maria ,   State University of Trade and Economics
Published: August 2024

The article is dedicated to substantiating the semantics of the organizational and economic mechanism of the functioning of tourism and hospitality entities under systemic crises. Considering the significant negative impact of Russia's full-scale war against Ukraine and the ongoing consequences of the global COVID-19 pandemic, the activities of these entities in certain regions of Ukraine (primarily in the west) show positive dynamics. Although in many regions, their activities are effectively halted, and in some, there have been significant reductions in their volumes. This suggests that in the post-war period, the development of Ukraine's tourism and hospitality sector will gain momentum due to pent-up demand and societal need for rest, recreation, and rehabilitation. At the same time, the current conditions of tourism and hospitality entities require a revision of the organizational and economic foundations of their functioning to survive and maintain certain socio-economic positions in the country's economy. The stabilization of activities and their effectiveness in the post-war period will largely depend on the ability to implement positive practices of effective functioning in crisis conditions and to extend them to the activities of all tourism and hospitality entities. Moreover, the experience of many business entities shows that most processes are implemented precisely through the organizational and economic mechanism. The structure of the organizational and economic mechanism of a tourism and hospitality entity is examined, with its main components being organizational structure, planning, financial management, marketing, pricing policy, personnel management, logistics and operational management, innovations and technologies, legal support, and environmental management. Factors influencing (internal and external) the organizational and economic mechanism of the functioning of tourism and hospitality entities that interact with each other are monitored, determining strategies and operational decisions in managing a hotel and a tourism enterprise, ultimately affecting their operational efficiency. Typical consequences of the crisis state of tourism and hospitality entities are formulated, and the main strategic directions for overcoming them are justified, which will require a comprehensive approach that includes both short-term measures for immediate crisis response and long-term strategies to ensure stable development.
Бакаянова Н. М. Історія адвокатури України : метод. вказівки для здобув. вищої освіти першого рівня за спец. 081 «Право» [Електронне видання]
Authors:   Національний університет ", Бакаянова Нана Мезенівна ,   Одеська юридична академія", Храпенко Олена Олегівна
Published: August 2024

Методичні вказівки підготовлені для здобувачів вищої освіти першого рівня НУ «Одеська юридична академія» з метою засвоєння ними знань про історичний розвиток адвокатури України. Містять перелік тем, які розглядаються під час навчання, та завдання, які студенти вирішують під час практичної роботи в процесі навчання; посилання на пам'ятники права, акти законодавства, що діяли на українських землях в різні історичні часи, чинне законодавство України та наукову літературу. Методичні вказівки призначені для здобувачів вищої освіти першого рівня за спеціальністю 081 «Право»
Pengaruh Pelatihan, Penghargaan Terhadap Perilaku Response Time Melalui Self Efficacy Perawat IGD
Authors: Gunarto Sugito Tri , Rondhianto  , Wijaya Dodi
Published: August 2024

Salah satu indikator mutu pelayanan di Instalasi Gawat Darurat adalah angka kematian. Penyebabnya tingginya angka kematian salah satunya adalah perilaku response time petugas. Penelitian ini bertujuan untuk mengidentifikasi pengaruh pelatihan dan penghargaan terhadap perilaku response time melalui self efficacy. Metode penelitian menggunakan cross-sectional. Sample penelitian yaitu perawat IGD Rumah Sakit tipe B di Jawa Timur sebanyak 102 orang dengan tehnik total sampling. Variabel terdiri dari pelatihan, penghargaan, perilaku response time dan self efficacy. Instrument penelitian menggunakan kuesioner. Analisis data menggunakan analisis deskripsi dan analisis inferensial menggunakan structural equation model (SEM). Hasil penelitian menunjukan sebagaian besar usia responden 18 – 40 tahun dengan presentasi 75,5 %, jenis kelamin sebagaian besar laki-laki dengan presentasi 69,6 %, pendidikan sebagaian besar ners sebesar 64,7 %. Hasil uji hipotesis dengan menggunakan SmartPLS menunjukkan pelatihan berpengaruh positip terhadap perilaku response time melalui self-efficacy dengan p-values sebesar 0.011. Sedangakan penghargaan berpengaruh positip terhadap perilaku response time melalui self-efficacy dengan p-values sebesar 0.004. Upaya peningkatan self efficacy dilakukan untuk meningkatkan perilaku response time petugas.
Myth, Mystery, and Murder: Trauma and Resistance in The Seven Moons of Maali Almeida
Authors: Saha Ashmita , Ghosh Sarbadhikary Mallika
Published: August 2024

This paper attempts to read Shehan Karunatilaka’s The Seven Moons of Maali Almeida, which is set against the 1980s Sri Lankan Civil War, and focuses primarily on how the mythic and magic realist elements within the narrative offer different variations of the idea of a national imaginary and delineate the intersectional traumatic experiences of the central character, Maali Almeida. Bronisław Malinowski, in his Myth in Primitive Psychology, stated that people in pain often turn to myths, legends, and folktales to seek a form of psychological escape from the repressions imposed by society. The novel, however, uses fantasy not as a form of psychological escape, but as a form of resistance against the chaos and injustice which the Civil War ensued. Designed partly as a whodunit, with the ghost of a dead gay atheist photojournalist searching for his killer, it provides certain avenues of exploration into trauma studies and also looks at how the central character rises above his own trauma by resorting to fantasy and magic realism. Moreover, by retaining the voice of the dead character, and also using a second person narrative style, it implicates the reader within the scheme of events and leaves open a possibility of overcoming trauma through a new understanding of the social and political institutions.
Editorial Introduction: Art as Subversion
Authors: Roy Binayak
Published: August 2024

Editorial
Transformasi Pemasaran Industri Logistik Dalam Meningkatkan Efisiensi Dan Keunggulan Kompetitif
Authors: Karjono Karjono , Diah Kusumawati Evyana , Karmanis Karmanis , Kusumaningrum Devi
Published: August 2024

Penelitian ini menginvestigasi transformasi pemasaran dalam industri logistik untuk meningkatkan efisiensi operasional dan mencapai keunggulan kompetitif. Penekanan utama adalah strategi pemasaran baru yang disesuaikan dengan dinamika pasar global dan teknologi terkini. Metode penelitian yang digunakan adalah metode kualitatif, dimana dalam penelitian ini nantinya menggunakan pendekatan studi kasus, fenomenologi, etnografi, grounded theory, atau pendekatan kualitatif lainnya dan melibatkan pengumpulan data melalui wawancara mendalam, pengamatan partisipatif, atau analisis dokumen. Jumlah sample dalam penelitian sebanyak 5 dari 51 industri yang ada di kawasan industri Semarang. Upaya untuk meningkatkan efisiensi operasional dan responsivitas layanan integrasi yang kurang memadai telah menghasilkan masalah seperti akses data terpadu yang terhambat, pelacakan yang kurang akurat, dan kompleksitas tinggi dalam mengintegrasikan platform-platform yang berbeda. Kendala antara platform, perbedaan format data, dan interoperabilitas sistem menjadi masalah krusial yang menghambat inovasi. Solusi potensial termasuk penggunaan platform terpadu atau standar industri seperti EDI atau API terbuka untuk memfasilitasi integrasi yang lebih mulus. Strategi yang direkomendasikan mencakup analisis mendalam kebutuhan pelanggan, fleksibilitas dalam layanan, pemanfaatan teknologi, kemitraan strategis, dan adaptasi terus-menerus terhadap strategi logistik.
Hambatan Operasional Kapal Supply Ditinjau Dari Kinerja Anak Buah Kapal SK Carina
Authors: Apriatna Cucu , Suswati Elis , Mustain Iing , Pramono Hadi
Published: August 2024

Peran kapal supply sebagai penunjang pengeboran gas lepas pantai menjadi bagain penting dalam pelayanan pengeboran gas. Masalah keterlambatan dalam bekerja karena kurang terampilnya Anak Buah Kapal (ABK) saat bekerja di kapal supply menjadi fokus dalam penelitian. Tujuan penelitian adalah menggambarkan hambatan operasional kapal supply yang ditinjau dari kinerja ABK. Metode penelitian menggunakan penelitian kualitatif deskriptif dengan data yang dikumpulkan melalui data primer yaitu observasi, wawancara, studi pustaka, dan dokumen pendukung sebagai data sekunder. Hasil penelitian diperoleh bahwa hambatan terjadi pada kapal supply yang disebabkan faktor manusia ditemukan adanya keterlambatan pada Kapal SK CARINA. Keterlambatan ini menimbulkan pekerjaan di platform tertunda dan pencharter mengalami kerugian karena biaya operasi di platform sangat mahal serta pekerjaan yang sudah seharusnya selesai jadi terlambat. Pekerjaan running cargo dan melayani Platform sangat dipengaruhi oleh ABK atau yang berkerja di kapal. ABK yang bekerja di Platform khusus mengangkat Cargo harus diberi pelatihan agar bisa memahami dan lebih terampil dalam bekerja.
Historik Ferdinand Uličný a dejiny stredovekého Bardejova
Authors: Fedorčáková Mária
Published: August 2024

Historian Ferdinand Uličný and the History of Medieval Bardejov This paper assesses Ferdinand Uličný´s contribution to the research of the medieval history of the town of Bardejov. Ferdinand Uličný represents the positivist trend in Slovak medieval studies, guided by the motto ad fontes. The author examines how this approach to the sources is reflected in Uličný´s works dedicated to Bardejov. The study highlights that in his initial work on the history of Bardejov from the late 1960s, F. Uličný already outlined the fundamental themes of research on this locality. During the 1970s and 1980s, Slovak historiography engaged in a debate over the interpretation of King Béla IV´s charter for the Bardejov Cistercians from 1247. Uličný addressed this charter in a study, responding to the theses of Branislav Varsik. However, as the article notes, Pavol Hudáček recently challenged some of Uličný‘s interpretations based on a broader analysis of sources, offering new insights into the earliest history of Bardejov and the issues surrounding this charter.
Application of the Discovery Learning Model to Improve Mathematics Learning Outcomes of Class XI Social Sciences
Authors: Rahmadayanti Jessy , Siregar Syarifah Nur
Published: August 2024

This study aims to improve the learning process to improve the mathematics learning outcomes of students in class XI IPS SMA Persada Pebenaan for the 2020/2021 academic year through the application of the Discovery Learning learning model. Collecting data involves observing the activities of teachers and students in action. This classroom action research consists of two cycles, each consisting of 3 meetings and one repetition. By applying the Discovery Learning model with a scientific approach, students must be more active in discovering concepts and materials to increase student learning activities. It was proven that the number of students who achieved KKM increased from cycle I to cycle II. In cycles I and II, students who pass the KKM have a success rate of 20% and 70%, respectively. Based on the research findings, the mathematics learning outcomes of class XI SMA Persada Pebenaan can be increased in the material for sequences and series using the Discovery Learning model.
The Real Problem with Constitutional Reform
Authors: Corner Mark
Published: August 2024

Discussion of how the UK can remain coherent as a multinational state needs to focus not on what powers might be given away to the regions and nations but on how to facilitate a sharing of power between different parts of the UK. This article examines how far programmes for constitutional reform, including the Welsh Senedd’s document Reforming our Union and the Labour Party’s A New Britain, have recognised the need for power-sharing in their discussion of matters like the reform of the House of Lords and the role of the Supreme Court. The conclusion is that current views of the sovereignty of the Westminster Parliament are incompatible with any meaningful constitutional reform. To change this would require a willingness to have constitutional arrangements much closer to those of the European Union, the very organisation which the UK decided in 2016 that it wanted to leave. It would also require seeing Northern Ireland less as a ‘troublesome province’ which needs to have its own form of government, but as an example of how progress can be made through power-sharing.
Complications of Endometriosis – Case Report of a Postoperative Recurrence of Rectovaginal Fistula
Authors: da Silva Rosimeire , Bindi Eduardo Delfino , da Silva Lucas Tonholo , Gonçalves Karoliny Moreira , Climeni Maíra Santi Orsi , de Azevedo Marcelo Vicentini , Michelin Mariana Loureiro Dias , Souza Paulo Vitor Carvalho , Freitas Ricardo , Fonseca Tatiana Cesário
Published: August 2024

Endometriosis is a disease with a poorly known etiology, characterized by the presence of dysfunctional endometrial tissue, which evolves to chronic inflammatory reactions in women of reproductive age, causing a great impact on the quality of life of this population, often leading to infertility. This article aims to describe the impact of endometriosis on women's health, as well as the complications it can cause. The information was obtained from interviews and access to the patient's medical records, analyzing diagnosis, surgical procedures, and complications. However, it is hoped to deepen the existing knowledge about endometriosis, emphasizing the importance of correct and early diagnosis of this disease and the risks of complications related to diagnosis, surgery, and rehabilitation.
Root nutrition of plants: relevance, needs, problem solving
Authors: Musych O. , Zubko O. , Dushko P.
Published: August 2024

The article theoretically analyzes the nutrient needs of plants and the balanced supply of macro- and microelements for their proper growth and development. The basis of the research methodology is the systematic approach of assessing the periodicity of foliar feeding of plants with complex preparations of various compositions. It has been established that with foliar fertilization there is a part of nutrients after they enter the plant leaf. Smaller molecules or molecules with less positive charge are more easily transported in the vascular system, from where they move to other parts of the plant, including ammonium, potassium, and urea. On the other hand, larger molecules and ions with a large positive charge tend to stay fairly close to their point of entry because they stick to the negatively charged cell walls. They hold immobile nutrients quite tightly, including calcium, iron, manganese, zinc, and copper. The importance of the combination of biotechnological and ecological aspects in the development and application of complex compounds for foliar fertilization is indicated. The use of compounds based on EDTA is potentially dangerous for agricultural products and the environment. In the long term, this leads to increased pollution of agricultural land, soil degradation, reduced yield, and deterioration of product quality. When applying complex foliar fertilizers, elements with a strong positive charge, such as calcium, do not move very actively in the plant. Accordingly, negatively charged elements, such as phosphorus, slowly enter the leaves of plants. Both elements are relatively stationary after entry. Additional studies have shown that different plant species differ significantly in their ability to absorb nutrients through their leaves. Differences in cuticle thickness, number of pores, and resistance, as well as genetic and environmental factors, all affect a species’ ability to assimilate nutrients applied to leaves.
A SYSTEMATIC APPROACH TO THE EVALUATION OF THE RESULTS OF THE FINAL EXAMINATION OF UNIVERSITY STUDENTS
Authors:   National Transport University, Dmytrychenko Nykolay , Tokin Oleksndr ,   National Transport University, Kharchenko Anna ,   National Transport University
Published: August 2024

Summary. The article is devoted to the consideration of a topical issue - the application of a systematic approach to the evaluation of the results of the final control of the knowledge of students of higher education at the university. The principles of organization, stages, main tasks and components of knowledge control of higher education seekers were studied, as well as the role of so-called pedagogical control was determined. The taxonomy of pedagogical goals, which determine the process of learning and evaluation of the achieved goals of education, and their relationship with the criteria for evaluating the knowledge of students of higher education at the university are considered. The results of the final control of the autumn examination session of the 2023-2024 academic year and the final certification of 2023 of higher education applicants at the National Transport University were analyzed, as well as their comparison with similar periods of the previous academic year. A study of the reporting of examination commissions was carried out and systematic measures were proposed to improve the quality of the educational process according to educational programs for the next academic year. In particular, it is proposed to continue the practice of considering issues of student success at meetings of academic councils of faculties and departments; to organize round tables to expand the competences of applicants on certain topics and problems with the involvement of specialists and scientists from various organizations; to intensify the publishing activity of higher education applicants; strengthen the work of involving leading specialists, employers, industry experts and practicing professionals in the educational process; to activate the interest of students in learning through the use of combined non-standard methods of learning and teaching; to continue work on the organization of field practices, excursions to enterprises with modern equipment, etc. Keywords: final control, assessment of knowledge level, learning outcomes, system approach, quality of the educational process
A PEEP INTO THE FUTURE THROUGH THE PAST: A BIBLIOMETRIC ANALYSIS ON WOMEN TRAVELERS
Authors: Soni Dr. Gagandeep , Hussain Sarah , Shekhar  , Chandan Dr. Rachna
Published: August 2024

The research explores the progress of studies on women travelers, examining publication trends, top contributors, collaborations, and thematic areas, while also exploring ways to make travel more convenient. For the achievement of these research questions, a bibliometric analysis has been conducted using data from the articles published in 41 journals dating from 1982 to 2023. For bibliometric analysis, collected data was analyzed with descriptive analysis, science mapping as bibliographic coupling, citation metrics, prestige analysis, keyword co-occurrence metrics; and network analysis as co-author analysis and co-citation analysis. The study reveals the top ten authors, organizations, and countries in women traveler-related literature, but a low total publication count suggests the need for comprehensive research. Five major themes that emerged were Women Travelers and Solo Travel, Women Travelers and Travel Motivation, Women Travelers and Purchase Intention, Women Travelers and Girlfriend Getaways, and Women Travelers, and Sexual Behaviour. The study identifies research gaps for future studies and suggests managerial actions to make women's travel more convenient. The study's values lie in enhancing the understanding of women traveler research, raising awareness of research frontiers, and guiding future directions in business travel niche market segments.
THE EFFECT OF PRECURSOR CONCENTRATION, pH OF THE SOLUTION AND CARBONATION DURATION ON CACO3 PARTICLE SIZE VIA CARBONATION METHOD
Authors: Febrida Renny , Faza Yanwar
Published: August 2024

Background. There are multiple techniques for generating CaCO3, one of which is the carbonation method. Currently, the particle size of CaCO3 is primarily determined by the combined influence of various variables. Objective. This study investigates the effect of precursor concentrations, pH of the solution, and carbonation duration on the size of CaCO3 particles Methods. The type of research in this study is experimental laboratory with a descriptive presentation of data. This study is divided into two stages: first, synthesis of CaCO3 with different concentration of precursors and carbonation duration. Second, it used different pH value of the solution and carbonation duration. The particle size of CaCO3 were characterized using the Particle Size Analyzer (PSA) (Horiba Scientific SZ-100 Nanopartica).  Result. The result show the smallest CaCO3 at first stage, 548 nm, obtained at concentration of 0.75 M with carbonation duration of 30 minutes. The largest CaCO3-size, 6194 nm, is seen at a 0.5 M concentration with a carbonation duration of 10 minutes. The second stage show the smallest particle size, 1165 nm, obtained at a pH value of 8 with a carbonation duration of 60 minutes. Meanwhile, the largest size, 5621 nm, is obtaining at a pH value of 9 with a carbonation duration of 90 minutes Conclusion. The concentration of precursors and the duration of carbonation have no effect on the size of CaCO3 particles, however the pH value of the solution may affect the particle size of CaCO3. It is directly proportional to the pH value of the solution
Torque-ratio-adjustable ankle-foot exoskeleton for resisting perturbation in forward direction within fan-shaped region of pelvis horizontal plane
Authors: Liu Yuyao , Sun Ronglei , Zou Kaijie , Li Ying , Xu Peng
Published: August 2024

Introduction: The ankle-foot exoskeleton has been demonstrated to help users resist anterior perturbation in the horizontal pelvis plane. However, its effects on perturbations in other directions remain unclear. This paper focuses on how the ankle-foot exoskeleton helps people resist perturbations coming from forward directions within the fan-shaped region in the pelvis horizontal plane.

Methods: Firstly, we proposed and validated a hypothesis that the human torque ratio of inversion to plantar flexion torque would change with the perturbation directions of anterior (dir0) and 45° deviating from anterior to left (dir45). Subsequently, based on the regulation demand, we developed an ankle-foot exoskeleton that can adjust the torque ratio delivered to the human body by controlling the forces on two cross-arranged cables. Finally, we evaluated and compared the assistance performance of three powered assistive modes (NM, medBD, and latBD) with the unpowered one (UN) by setting different force pairs in two cables.

Results: The results showed that, with the assistance, the margin of stability was increased and the standard deviations of ankle-foot segmental movements were decreased. Meanwhile, the biological inversion torque has a significant difference among the three assistive modes. Compared to the UN, the latBD was shown to reduce the biological inversion torque by 15.8% and 13.7% in response to the dir0 and dir45 perturbations, respectively, while the reductions for the NM and medBD were smaller. It was also observed that the torque ratios, generated by the human and the exoskeleton in latBD mode, differed by about 0.1 under dir0 and 0.08 under dir45, while the physiologically similarity of the exoskeleton torque ratio in NM and medBD modes were smaller. Based on the above results, we found that the more physiologically similar the exoskeleton torque ratio, the better the assistive performance.

Discussion: The findings demonstrated that the torque-ratio-adjustable exoskeleton could support human resistance to perturbations coming from forward directions within a fan-shaped region in the pelvis horizontal plane and indicated that the exoskeleton’s torque ratio should be carefully modulated to match the ratio of the human under various environmental conditions for better assistive performance.
Moving from lipids to leukocytes: inflammation and immune cells in atherosclerosis
Authors: Annink Maxim E. , Kraaijenhof Jordan M. , Stroes Erik S. G. , Kroon Jeffrey
Published: August 2024

Atherosclerotic cardiovascular disease (ASCVD) is the most important cause of morbidity and mortality worldwide. While it is traditionally attributed to lipid accumulation in the vascular endothelium, recent research has shown that plaque inflammation is an important additional driver of atherogenesis. Though clinical outcome trials utilizing anti-inflammatory agents have proven promising in terms of reducing ASCVD risk, it is imperative to identify novel actionable targets that are more specific to atherosclerosis to mitigate adverse effects associated with systemic immune suppression. To that end, this review explores the contributions of various immune cells from the innate and adaptive immune system in promoting and mitigating atherosclerosis by integrating findings from experimental studies, high-throughput multi-omics technologies, and epidemiological research.
Retrieval of Cu2+ and Cd2+ ions from aqueous solutions using sustainable guar gum/PVA/montmorillonite nanocomposite films: effect of temperature and adsorption isotherms
Authors: Alhaithloul Haifa A. S. , Alsudays Ibtisam Mohammed , Zaki ElSayed G. , Elsaeed Shymaa M. , Mubark Amal E. , Salib Lurana , Safwat Gehan , Niedbała Gniewko , Diab Ayman , Abdein Mohamed A. , Alharthi Afaf , Zakai Shadi A. , Elkelish Amr
Published: August 2024

Uncontrolled or improperly managed wastewater is considered toxic and dangerous to plants, animals, and people, as well as negatively impacting the ecosystem. In this research, the use of we aimed to prepare polymer nanocomposites (guar gum/polyvinyl alcohol, and nano-montmorillonite clay) for eliminating heavy metals from water-based systems, especially Cu2+ and Cd2+ ions. The synthesis of nanocomposites was done by the green method with different ratios of guar gum to PVA (50/50), (60/40), and (80/20) wt%, in addition to glycerol that acts as a cross-linker. Fourier-transform infrared spectroscopy (FT-IR) analysis of the prepared (guar gum/PVA/MMT) polymeric nano-composites’ structure and morphology revealed the presence of both guar gum and PVA’s functional groups in the polymeric network matrix. Transmission electron microscopy (TEM) analysis was also performed, which verified the creation of a nanocomposite. Furthermore, theromgravimetric analysis (TGA) demonstrated the biocomposites’ excellent thermal properties. For those metal ions, the extreme uptake was found at pH 6.0 in each instance. The Equilibrium uptake capacities of the three prepared nanocomposites were achieved within 240 min. The maximal capacities were found to be 95, 89 and 84 mg/g for Cu2+, and for Cd2+ were found to be 100, 91, 87 mg/g for guar gum (80/20, 60/40 and 50/50), respectively. The pseudo-2nd-order model with R2 > 0.98 was demonstrated to be followed by the adsorption reaction, according to the presented results. In less than 4 hours, the adsorption equilibrium was reached. Furthermore, a 1% EDTA solution could be used to revitalize the metal-ion-loaded nanocomposites for several cycles. The most promising nanocomposite with efficiency above 90% for the removal of Cu2+ and Cd2+ ions from wastewater was found to have a guar (80/20) weight percentage, according to the results obtained.
Development of idealized human aortic models for in vitro and in silico hemodynamic studies
Authors: Mansouri Hamid , Kemerli Muaz , MacIver Robroy , Amili Omid
Published: August 2024

Background

The aorta, a central component of the cardiovascular system, plays a pivotal role in ensuring blood circulation. Despite its importance, there is a notable lack of idealized models for experimental and computational studies.

Objective

This study aims to develop computer-aided design (CAD) models for the idealized human aorta, intended for studying hemodynamics or solid mechanics in both in vitro and in silico settings.

Methods

Various parameters were extracted from comprehensive literature sources to evaluate major anatomical characteristics of the aorta in healthy adults, including variations in aortic arch branches and corresponding dimensions. The idealized models were generated based on averages weighted by the cohort size of each study for several morphological parameters collected and compiled from image-based or cadaveric studies, as well as data from four recruited subjects. The models were used for hemodynamics assessment using particle image velocimetry (PIV) measurements and computational fluid dynamics (CFD) simulations.

Results

Two CAD models for the idealized human aorta were developed, focusing on the healthy population. The CFD simulations, which align closely with the PIV measurements, capture the main global flow features and wall shear stress patterns observed in patient-specific cases, demonstrating the capabilities of the designed models.

Conclusions

The collected statistical data on the aorta and the two idealized aorta models, covering prevalent arch variants known as Normal and Bovine types, are shown to be useful for examining the hemodynamics of the aorta. They also hold promise for applications in designing medical devices where anatomical statistics are needed.
Prevalence and influencing factors of subjects at high risk for cardiovascular disease in different regions of Gansu province, China: a cross-sectional study of 100,725 residents from 2017 to 2022
Authors: Li Yixuan , Zhang Chouji , Chen Faqing , Zhang Jing
Published: August 2024

Background

To investigate the prevalence rate of subjects at high risk for cardiovascular disease (CVD) and to analyze the influencing factors in different regions of Gansu Province.

Methods

We used data from the China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project (MPP), which screened 100,725 residents aged 35–75 years from 10 project sites in Gansu Province, China, from 2017 to 2022. In addition, a questionnaire survey, anthropometric measurements, and collection of biological samples were carried out.

Results

Of the 100,082 residents included, 21,059 were identified as subjects at high-risk for CVD. The overall prevalence rate of subjects at high risk for CVD was 19.7%, and the prevalence rate in the HeXi region was greater than that in the LongZhong and LongDong regions. The prevalence rates were 14.0%, 58.2%, 34.9%, and 5.7% for cardiovascular history, hypertension, dyslipidemia, and WHO-assessed risk ≥20%, respectively. The prevalence rate of cardiovascular history type was the highest in the HeXi region, hypertension and dyslipidemia types were the highest in the LongZhong region, and WHO-assessed risk ≥20% type was the highest in the LongDong region. Male, higher education level, smoking status, snoring status, overweight and obesity status, central obesity status, and disease history were more likely to be risk factors for subjects at high risk for CVD. There were some differences among different regions in age, annual household income, farming status, rural/urban status, and drinking status.

Conclusion

The prevalence rate of subjects at high risk for CVD in Gansu Province is relatively high. Individualized intervention measures as well as comprehensive prevention and control strategies should be adopted, focusing on the distribution characteristics of risk factors among high-risk subjects in different regions.