bluuebunny/crossref_metadata_2025 huggingface dataset:
Prioritizing outcome measures after aneurysmal subarachnoid hemorrhage: A q-sort survey of patients, health care providers and researchers
Authors: Andersen Christopher R. , Presseau Justin , Saigle Victoria , Fitzgerald Emily , Lamanna Madeline , Talbot Phil , Delaney Anthony , English Shane W.
Published: November 2022

Objective

To understand which outcome measures patients and their families, health care providers, and researchers prioritize after aneurysmal subarachnoid hemorrhage (aSAH).

Methods

We conducted a cross-sectional q-sort survey with participants from three key stakeholder groups. Potential outcomes were identified from interviews and focus groups. Participants were purposively sampled to achieve diversity based on stakeholder group, geography, and profession. Respondents sorted 27 outcomes in a quasi-normally distributed grid (Q-Sort) from most to least important. Principal components analysis was used to determine similarities in the way participants sorted the outcome measures resulting in distinct groupings. Overall rankings were also reported.

Results

112 participants were invited. 70 responded and 64 participants from 25 different countries completed a Q-sort. Balanced stakeholder representation was achieved. Five distinct patterns were identified based on survival, pathophysiological, psychological, resource use, and functional outcome measures. Quality of life as reported by the patient was the highest ranked outcome measure followed by independence and functional measures. Survival and biomedical outcomes were ranked in the middle and cost measures last.

Conclusions

In this diverse sample of key stakeholders, we characterized several distinct perspectives with respect to outcome measure selection in aSAH. We did not identify a clear pattern of opinion based on stakeholder group or other participant characteristics. Patient-reported measure of quality of life was ranked the most important overall with function and independence also highly rated. These results will assist study design and inform efforts to improve outcome selection in aSAH research.
Gaze instability after exposure to moving visual stimuli in patients with persistent postural-perceptual dizziness
Authors: Yagi Chihiro , Morita Yuka , Yamagishi Tatsuya , Ohshima Shinsuke , Izumi Shuji , Takahashi Kuniyuki , Itoh Kosuke , Suzuki Yuji , Igarashi Hironaka , Horii Arata
Published: November 2022

Introduction

Persistent postural-perceptual dizziness (PPPD) is a chronic vestibular syndrome lasting more than 3 months. The core vestibular symptoms are dizziness, unsteadiness, and non-spinning vertigo, which are exacerbated by upright posture or walking, active or passive motion, and exposure to moving or complex visual stimuli. Among these, visual exacerbation is a key feature of PPPD for which the neural mechanisms are unknown. We hypothesized that vestibular symptoms may be exacerbated by visual stimuli through gaze behavioral change after exposure to moving or complex visual stimuli. The study aimed to examine gaze stability after exposure to moving visual stimuli in patients with PPPD.

Methods

Fourteen healthy controls (HCs), 27 patients with PPPD, and 12 patients with unilateral vestibular hypofunction (UVH), showing chronic vestibular symptoms for >3 months, were enrolled in the study. The participants were instructed to fixate on the gazing point at the center of a screen for 30 s before and after 90 s of exposure to moving visual stimuli. Gaze stability, best represented by the bivariate contour ellipse area (BCEA), was compared among three groups, both before and after exposure to the moving visual stimuli. Comparisons between pre- and post-moving visual stimuli in BCEA were also conducted. Correlation between the post/pre ratio of BCEA and vestibular tests, several clinical symptom scales including the Dizziness Handicap Inventory, Niigata PPPD Questionnaire, and Hospital Anxiety and Depression Scale, and the exacerbation of dizziness by exposure to moving visual stimuli was examined in the PPPD group.

Results

BCEA, both before and after exposure to moving visual stimuli in the PPPD group, was not different from that in HC and UVH groups. In the PPPD group, BCEA increased significantly after exposure to moving visual stimuli. The post/pre ratio of BCEA correlated with the occurrence of exacerbation of the dizziness sensation by exposure to moving visual stimuli; however, it did not correlate with vestibular tests or clinical symptom scales.

Conclusion

Patients with PPPD were more likely to exhibit gaze instability after exposure to moving visual stimuli, which potentially exacerbated vestibular symptoms. This phenomenon may help elucidate the neural mechanisms of visual exacerbation in patients with PPPD.
Bi-dimensional values and attitudes toward online fast food-buying intention during the COVID-19 pandemic: An application of VAB model
Authors: Yan Chen , Siddik Abu Bakkar , Masukujjaman Mohammad , Dong Qianli , Hamayun Muhammad , Guang-Wen Zheng , Ibrahim Abdullah Mohammed
Published: November 2022

The purpose of the study is to determine the factors of online fast food-buying intention among Bangladeshi Millennials during the COVID-19 pandemic. The study adopted the Value-Attitude-Behavior (VAB) model and designed it as a higher-order constructs model to predict buying intention. Using a quantitative method (i.e., cross-sectional survey), data was collected from 325 respondents via a structured questionnaire and subsequently analyzed using Structural Equation Modeling (SEM) through AMOS software. The findings of the study revealed that convenience and food quality generate utilitarian values, while subjective norms and novelty-seeking form hedonic values. Also, utilitarian and hedonic values significantly affect cognitive and affective attitudes. As opposed to food quality, the cognitive attitude, affective attitude, self-identity, and subjective norms were observed to affect behavioral intention, with affective attitude producing the strongest association, albeit with the high explanatory power of the model. Consequently, this study offers a number of theoretical and policy implications to design better interventions that address public health regarding fast food consumption.
Salivary gland cancers in elderly patients: challenges and therapeutic strategies
Authors: Colombo Elena , Van Lierde Charlotte , Zlate Alexandra , Jensen Alexandra , Gatta Gemma , Didonè Fabio , Licitra Lisa F. , Grégoire Vincent , Vander Poorten Vander , Locati Laura D.
Published: November 2022

Salivary gland carcinomas (SGCs) are the most heterogeneous subgroup of head and neck malignant tumors, accounting for more than 20 subtypes. The median age of SGC diagnosis is expected to rise in the following decades, leading to crucial clinical challenges in geriatric oncology. Elderly patients, in comparison with patients aged below 65 years, are generally considered less amenable to receiving state-of-the-art curative treatments for localized disease, such as surgery and radiation/particle therapy. In the advanced setting, chemotherapy regimens are often dampened by the consideration of cardiovascular and renal comorbidities. Nevertheless, the elderly population encompasses a broad spectrum of functionalities. In the last decades, some screening tools (e.g. the G8 questionnaire) have been developed to identify those subjects who should receive a multidimensional geriatric assessment, to answer the question about the feasibility of complex treatments. In the present article, we discuss the most frequent SGC histologies diagnosed in the elderly population and the relative 5-years survival outcomes based on the most recent data from the Surveillance, Epidemiology, and End Results (SEER) Program. Moreover, we review the therapeutic strategies currently available for locoregionally advanced and metastatic disease, taking into account the recent advances in precision oncology. The synergy between the Multidisciplinary Tumor Board and the Geriatrician aims to shape the most appropriate treatment pathway for each elderly patient, focusing on global functionality instead of the sole chronological age.
Clinic friendly estimation of muscle composition: Preoperative linear segmentation shows overall survival correlated with muscle mass in patients with nonmetastatic renal cell carcinoma
Authors: Schmeusser Benjamin N. , Midenberg Eric , Palacios Arnold R. , Vettikattu Nikhil , Patil Dattatraya H. , Medline Alexandra , Higgins Michelle , Armas-Phan Manuel , Nabavizadeh Reza , Joshi Shreyas S. , Narayan Vikram M. , Psutka Sarah P. , Ogan Kenneth , Bilen Mehmet A. , Master Viraj A.
Published: November 2022

Purpose

Sarcopenia is associated with decreased survival and increased complications in patients with renal cell carcinoma. Readily identifying patients with low muscle composition that may experience worse outcomes or would benefit from preoperative intervention is of clinical interest. Traditional body composition analysis methods are resource intensive; therefore, linear segmentation with routine imaging has been proposed as a clinically practical alternative. This study assesses linear segmentation’s prognostic utility in nonmetastatic renal cell carcinoma.

Materials and Methods

A single institution retrospective analysis of patients that underwent nephrectomy for nonmetastatic renal cell carcinoma from 2005-2021 was conducted. Linear segmentation of the bilateral psoas/paraspinal muscles was completed on preoperative imaging. Total muscle area and total muscle index associations with overall survival were determined by multivariable analysis.

Results

532 (388 clear cell) patients were analyzed, with median (IQR) total muscle index of 28.6cm2/m2 (25.8-32.5) for women and 33.3cm2/m2 (29.1-36.9) for men. Low total muscle index was associated with decreased survival (HR=1.96, 95% CI 1.32-2.90, p<0.001). Graded increases in total muscle index were associated with better survival (HR=0.95, 95% CI 0.92-0.99, p=0.006).

Conclusions

Linear segmentation, a clinically feasible technique to assess muscle composition, has prognostic utility in patients with localized renal cell carcinoma, allowing for incorporation of muscle composition analysis into clinical decision-making. Muscle mass determined by linear segmentation was associated with overall survival in patients with nonmetastatic renal cell carcinoma.
Radiomics of dynamic contrast-enhanced magnetic resonance imaging parametric maps and apparent diffusion coefficient maps to predict Ki-67 status in breast cancer
Authors: Feng Shuqian , Yin Jiandong
Published: November 2022

Purpose

This study was aimed at evaluating whether a radiomics model based on the entire tumor region from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parametric maps and apparent diffusion coefficient (ADC) maps could indicate the Ki-67 status of patients with breast cancer.

Materials and methods

This retrospective study enrolled 205 women with breast cancer who underwent clinicopathological examination. Among them, 93 (45%) had a low Ki-67 amplification index (Ki-67 positivity< 14%), and 112 (55%) had a high Ki-67 amplification index (Ki-67 positivity ≥ 14%). Radiomics features were extracted from three DCE-MRI parametric maps and ADC maps calculated from two different b values of diffusion-weighted imaging sequences. The patients were randomly divided into a training set (70% of patients) and a validation set (30% of patients). After feature selection, we trained six support vector machine classifiers by combining different parameter maps and used 10-fold cross-validation to predict the expression level of Ki-67. The performance of six classifiers was evaluated with receiver operating characteristic (ROC) analysis, sensitivity, and specificity in both cohorts.

Results

Among the six classifiers constructed, a radiomics feature set combining three DCE-MRI parametric maps and ADC maps yielded an area under the ROC curve (AUC) of 0.839 (95% confidence interval [CI], 0.768−0.895) within the training set and 0.795 (95% CI, 0.674−0.887) within the independent validation set. Additionally, the AUC value, compared with that for a single parameter map, was moderately increased by combining features from the three parametric maps.

Conclusions

Radiomics features derived from the DCE-MRI parametric maps and ADC maps have the potential to serve as imaging biomarkers to determine Ki-67 status in patients with breast cancer.
A novel defined cuproptosis-related gene signature for predicting the prognosis of colon adenocarcinoma
Authors: Luo Bixian , Lin Jianwei , Ni Anqi , Cai Wei , Yu Xinbo , Wang Mingliang
Published: November 2022

The prognosis of colon adenocarcinoma (COAD) needs to be improved. Cuproptosis is a recently discovered cell death caused by intracellular overload of copper ions. There have been no reports about the cuproptosis-related prognostic model in COAD. First, we screened 30 differentially expressed genes (DEGs) from patients with COAD using The Cancer Genome Atlas (TCGA) database. Gene Expression Omnibus (GEO) database was used as a validation set to establish a risk model of five cuproptosis-related genes (CKDN2A, SDHB, CCS, ULK1, and CMC1) by least absolute shrinkage and selection operator (LASSO) Cox regression analysis. In both TCGA and GEO cohorts, we could see that overall survival of COAD patients of the low-risk group was longer. Combined with the clinical characteristics, the risk score was found to be an independent prognostic factor. Furthermore, single-sample Gene Set Enrichment Analysis (ssGSEA) showed that the levels of Th1 and Treg immune cells changed both in TCGA and GEO databases. Finally, clinical samples were used to verify the mRNA and protein levels of five risk-model genes. In conclusion, this model could predict the prognosis of COAD patients, and the mechanism may be related to the changes in immune cells in the tumor microenvironment (TME).
Which lymph node dissection template is optimal for radical cystectomy? A systematic review and Bayesian network meta-analysis
Authors: Qi Wenqiang , Zhong Minglei , Jiang Ning , Zhou Yongheng , Lv Guangda , Li Rongyang , Shi Benkang , Chen Shouzhen
Published: November 2022

Objective

This study aims to determine the optimal pelvic lymph node dissection (PLND) template for radical cystectomy (RC).

Methods

A systematic search was conducted using the PubMed, Embase and Cochrane Library database in December 2021. Articles comparing recurrence-free survival (RFS), disease-specific survival (DSS), overall survival (OS), and postoperative complications among patients undergoing limited PLND (lPLND), standard PLND (sPLND), extended PLND (ePLND), or super-extended PLND (sePLND) were included. A Bayesian approach was used for network meta-analysis.

Results

We included 18 studies in this systematic review, and 17 studies met our criteria for network meta-analysis. We performed meta-analyses and network meta-analyses to investigate the associations between four PLND templates and the RFS, DSS, OS, or postoperative complications. We found that the ePLND group and the sePLND group were associated with better RFS than the sPLND group (Hazard Ratio [HR]: 0.65, 95% Credible Interval [CrI]: 0.56 to 0.78) (HR: 0.67, 95% CrI: 0.56 to 0.83) and the lPLND group (HR: 0.67, 95% CrI: 0.50 to 0.91) (HR: 0.70, 95% CrI: 0.49 to 0.99). For RFS, Analysis of the treatment ranking revealed that ePLND had the highest probabilities to be the best template. There was no significant difference between the four templates in DSS, however, analysis of the treatment ranking indicated that sePLND had the highest probabilities to be the best template. And We found that the sePLND group and the ePLND group were associated with better OS than lPLND (HR: 0.58, 95% CrI: 0.36 to 0.95) (HR: 0.63, 95% CrI: 0.41 to 0.94). For OS, analysis of the treatment ranking revealed that sePLND had the highest probabilities to be the best template. The results of meta-analyses and network meta-analyses showed that postoperative complications rates did not differ significantly between any two templates.

Conclusion

Patients undergoing sePLND and ePLND had better RFS but not better DSS or OS than those undergoing lPLND or sPLND templates, however, RFS did not differ between patients undergoing sePLND or ePLND. Considering that sePLND involves longer operation time, higher risk, and greater degree of difficulty than ePLND, and performing sePLND may not result in better prognosis, so it seems that there is no need for seLPND. We think that ePLND might be the optimal PLND template for RC.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42022318475.
Color Doppler imaging characteristics of RPE neoplasms: A study of 17 cases
Authors: Zhou Nan , Yang Wenli , Wei Wenbin
Published: November 2022

Purpose

To report the color Doppler imaging (CDI) features of 17 patients with retinal pigment epithelium (RPE) neoplasms.

Design

Retrospective, observational case series.

Participants

Seventeen patients with RPE adenoma/adenocarcinoma.

Methods

Contrast-enhanced color Doppler ultrasonography (CDU) was performed in 16 patients with RPE adenoma and in one patient with adenocarcinoma.

Result

All 17 RPE neoplasms showed well-defined margins. An oval mass was observed in 11 tumors, a lenticular-shaped mass in four tumors, and a flat mass in two tumors. On CDI, RPE lesions showed homogeneous reflectivity of moderate intensity with no choroidal excavation. After the contrast-enhanced administration of sulfur hexafluoride, mild enhancement was identified in six tumors and moderate enhancement in 11 tumors. In all 17 RPE neoplasms, contrast-enhanced CDU time–intensity curves (TICs) exhibited fast fill-in and slow washout-shaped curves with the dominant vessel within RPE lesions. A “black-linear” sign (defined as a low signal intensity-linear zone located between the tumor and enhanced choroid on CDI) was noted in all 17 patients with RPE neoplasms.

Conclusions

This preliminary study noted a “black-linear” sign on CDI of RPE lesions for the first time. The novel sign may be a diagnostic characteristic of RPE neoplasms and may help to distinguish this rare entity from uveal melanomas (UMs).
Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation
Authors: Li Xiaochun , Shen Xueqiang , Wang Zhiqiang , Jiang Hong , Ma Zhijia , Yu Pengfei , Yu Zhenhan , Qian Xiang , Liu Jintao
Published: November 2022

Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.

Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation (LDH) undergoing discectomy in our hospital were selected, including 4 ruptured and 4 non-ruptured herniated nucleus pulposus cases. Total RNA was extracted from cells by using TRIzol reagent. Nucleus pulposus cDNA probes of the two groups were obtained by the single marker method and hybridized with a human gene expression profiling chip (Agilent). The fluorescence signal images were scanned by a laser, and the obtained genes were analyzed by bioinformatics.

Results: There were 75 differentially expressed genes with more than 2-fold-changes, of which 56 were up-regulated and 19 were down-regulated. The differential expression of THSD7A, which was up-regulated 18 times, was the most significant, followed by CCL5, AQP3 and SDC4.

Conclusion: THSD7A can be used as a characteristic differentially expressed gene in human ruptured nucleus pulposus. Moreover, CCL5, AQP3 and SDC4 may improve the chemotaxis of stem cell migration for self-healing of damaged disc tissue, increase water uptake by nucleus accumbens cells, and inhibit the inflammatory response, thus delaying the process of intervertebral disc degeneration.
Potential global distribution area projections of the aphid Lipaphis erysimi and its predator Eupeodes corollae in the context of climate change
Authors: Lian Yuyang , Wang Aqiang , Peng Sihua , Jia Jingjing , Yang Xiaofeng , Li Jinlei , Yang Shuyan , Zheng Rongjiao , Zhou Shihao
Published: November 2022

Climate change affects the population distribution of pests and their natural enemies, and predicting these effects is necessary for pest monitoring and green control. Lipaphis erysimi is an important vegetable pest, and its natural enemy, the Eupeodes corollae Fabricius has a strong predatory effect on the L. erysimi. To assess the spread trends of L. erysimi and its natural enemy, the hoverfly, E. corollae under current (1970-2000) and future climates (2041-2060), based on the MaxEnt model, this paper uses data on the geographical distribution of the historical occurrence of L. erysimi and E. corollae to speculate on their potential distribution areas worldwide and analyze the key environmental factors affecting the survival and spread of both. The results showed that the Representative Concentration Pathway (RCP) 2.6 and RCP4.5 climatic conditions are favorable for the spread of L. erysimi, the RCP8.5 climatic conditions are unfavorable for the spread of L. erysimi, and all three future climatic conditions are unfavorable for the spread of E. corollae. The highest fitness of L. erysimi was found at the annual average temperature of 18 °C and the annual average precipitation of 900 mm, while the highest fitness of E. corollae was found at the annual average temperature of 10 °C and the lowest temperature in the coldest month of 0 °C. This study can provide a reference basis for monitoring and early warning and biological control of L. erysimi.
Development of real-time PCR and droplet digital PCR based marker for the detection of Tilletia caries inciting common bunt of wheat
Authors: Ren Zhaoyu , Chen Rongzhen , Muhae-Ud-Din Ghulam , Fang Mingke , Li Tianya , Yang Yazheng , Chen Wanquan , Gao Li
Published: November 2022

This is the first study reporting droplet digital PCR and quantitative real time PCR for detection of Tilletia caries (syn. T. tritici), which causes common bunt of wheat and leads to yield losses of 80% in many wheat growing areas worldwide. To establish an accurate, rapid and quantifiable detection method, we tested 100 inter simple sequence repeats (ISSR) primers and obtained a species-specific fragment (515 bp) generated by ISSR 827. Then, a specific 266 bp band for the sequence characterized amplified region (SCAR) marker was produced from T. caries. The detection limit reached 50 pg/μL. Based on the SCAR marker, we further developed a higher sensitivity of quantitative real time-polymerase chain reaction (qRT-PCR) with a detection limit of 2.4 fg/μL, and droplet digital PCR (ddPCR) with a detection limit of 0.24 fg/μL. Both methods greatly improved the detection sensitivity of T. caries, which will be contribute a lot for quickly and accurately detection of T. caries, which causes wheat common bunt.
Improvement in Brazilian barley breeding: Changes in developmental phases and ecophysiological traits
Authors: Rodrigues Osmar , Minella Euclydes , Costenaro Edson Roberto , Scariotto Silvia , Marchese José Abramo
Published: November 2022

Despite recognizing the importance of genetic improvement in the production of barley grains, little information is available on the contribution of phenological development to the genetic improvement of Brazilian barley. Field experiments were carried out between 2011 to 2013, in the absence of biotic and abiotic stresses and with preventive lodging control. Five two-rowed spring barley cultivars, released between 1968 and 2008, were evaluated. Although there was no significant association in the cycle length (Emergence - Anthesis) of the cultivars with the year of release, the genetic improvement increased the proportion of the Doble ridge - Maximum number of spikelet primordia/Maximum number of spikelet primordia - anthesis period to the total time to anthesis. The period between DR-MNP was increased in modern cultivars, to the detriment of the Doble ridge - Maximum number of spikelet primordia period. However, the duration of the period between emergences to the double ridge (vegetative phase) was not altered in the analyzed period. Barley breeding in Brazil did not change the total number of leaves on the main stem but caused an increase in the number of leaves earlier in the development, favoring the high level of tillering. The leaf architecture of modern barley was altered towards a more vertical inclination (erectophilic canopy), allowing the penetration of photosynthetically active radiation into the crop canopy.
Comparative transcriptomic provides novel insights into the soybean response to Colletotrichum truncatum infection
Authors: Boufleur Thaís R. , Massola Júnior Nelson S. , Becerra Sioly , Baraldi Elena , Bibiano Líllian B. J. , Sukno Serenella A. , Thon Michael R. , Baroncelli Riccardo
Published: November 2022

Introduction

Soybean (Glycine max) is among the most important crops in the world, and its production can be threatened by biotic diseases, such as anthracnose. Soybean anthracnose is a seed-borne disease mainly caused by the hemibiotrophic fungus Colletotrichum truncatum. Typical symptoms are pre- and post-emergence damping off and necrotic lesions on cotyledons, petioles, leaves, and pods. Anthracnose symptoms can appear early in the field, causing major losses to soybean production.

Material and Methods

In preliminary experiments, we observed that the same soybean cultivar can have a range of susceptibility towards different strains of C. truncatum, while the same C. truncatum strain can cause varying levels of disease severity in different soybean cultivars. To gain a better understanding of the molecular mechanisms regulating the early response of different soybean cultivars to different C. truncatum strains, we performed pathogenicity assays to select two soybean cultivars with significantly different susceptibility to two different C. truncatum strains and analyzed their transcriptome profiles at different time points of interaction (0, 12, 48, and 120 h post-inoculation, hpi).

Results and Discussion

The pathogenicity assays showed that the soybean cultivar Gm1 is more resistant to C. truncatum strain 1080, and it is highly susceptible to strain 1059, while cultivar Gm2 shows the opposite behavior. However, if only trivial anthracnose symptoms appeared in the more resistant phenotype (MRP; Gm1-1080; Gm2-1059) upon 120 hpi, in the more susceptible phenotype (MSP; Gm-1059; Gm2- 1080) plants show mild symptoms already at 72 hpi, after which the disease evolved rapidly to severe necrosis and plant death. Interestingly, several genes related to different cellular responses of the plant immune system (pathogen recognition, signaling events, transcriptional reprogramming, and defense-related genes) were commonly modulated at the same time points only in both MRP. The list of differentially expressed genes (DEGs) specific to the more resistant combinations and related to different cellular responses of the plant immune system may shed light on the important host defense pathways against soybean anthracnose.
The unique and compensatory effects of home and classroom learning activities on Migrant and Seasonal Head Start children’s Spanish and English emergent literacy skills
Authors: Luo Rufan , Song Lulu
Published: November 2022

Children of migrant and seasonal farmworkers (MSFW) are among the most underprivileged, underserved groups in the United States. The current study examined how home and classroom language and literacy experiences uniquely and interactively contributed to MSFW children’s emergent literacy skills in English and Spanish. Participants were 255 Spanish-English dual language learning children (Mage = 49 mon; 98.3% Latino/Hispanic) and their parents and 47 teachers, drawn from the Migrant and Seasonal Head Start (MSHS) Study. Parents reported how often the target children engaged in language and literacy activities (i.e., teaching letters, words, or numbers, book-reading, singing, and storytelling) with their family members. Teachers reported how often the target children engaged in classroom language and literacy activities (e.g., book-reading, learning letters, retelling stories, etc.). Children’s emergent literacy skills in English and Spanish were assessed by standard tests. After controlling for demographic variables, home and classroom language and literacy activities uniquely predicted children’s emergent literacy skills in Spanish, but not in English. Additionally, home and classroom activities compensated one another in supporting children’s English and Spanish emergent literacy development. That is, language and literacy activities in one context showed a stronger effect for children who experienced less frequent activities in the other context. Together, these findings shed light on ways to support MSFW children’s emergent literacy skills and reveal the importance of integrating and connecting home and school learning experiences.
COVID-19 and mental health: A systematic review of international medical student surveys
Authors: Paz Dean C. , Bains Manav Singh , Zueger Morgan L. , Bandi Varasiddimounish R. , Kuo Victor Y. , Cook Kyle , Ryznar Rebecca
Published: November 2022

Background

The medical school curriculum has imposed psychological stressors on students worldwide, some of which may induce feelings of increased depression and anxiety. Meanwhile, the COVID-19 pandemic has exacerbated the feelings of stress, depression, and anxiety that a portion of medical students experience in their daily life. The aim of this systematic review is to gather concrete data from medical schools around the globe, and further evaluate how the COVID-19 pandemic has impacted medical students’ mental health.

Materials and methods

Systematic search of data from PubMed, EMBASE, psycINFO, MEDLINE Complete, and Global Health for studies conducted between December 2019 and July 2021 was conducted. Data from 47 different surveys of medical students from various medical institutions throughout the world were included in this review. These surveys, administered in the form of questionnaires that utilized rating scales, measured anxiety, depression, and stress levels in medical students amidst the COVID-19 outbreak.

Results

The COVID-19 outbreak was found to have negative effects on medical students, most notably causing emotional and behavioral changes and detrimental mental health impacts. Higher levels of stress, depression, and anxiety have been found in medical students since the outbreak.

Conclusion

This systematic review highlights the sustained high prevalence of moderate depression, anxiety and stress among medical students during the COVID-19 pandemic. Appropriate support and research on which interventions could mitigate these risks is essential in order to ensure that future physicians are properly cared for, and ultimately have the adequate tools needed to provide high quality and empathetic care to future patients.
An ingroup disadvantage in recognizing micro-expressions
Authors: Wu Qi , Peng Kunling , Xie Yanni , Lai Yeying , Liu Xuanchen , Zhao Ziwei
Published: November 2022

Micro-expression is a fleeting facial expression of emotion that usually occurs in high-stake situations and reveals the true emotion that a person tries to conceal. Due to its unique nature, recognizing micro-expression has great applications for fields like law enforcement, medical treatment, and national security. However, the psychological mechanism of micro-expression recognition is still poorly understood. In the present research, we sought to expand upon previous research to investigate whether the group membership of the expresser influences the recognition process of micro-expressions. By conducting two behavioral studies, we found that contrary to the widespread ingroup advantage found in macro-expression recognition, there was a robust ingroup disadvantage in micro-expression recognition instead. Specifically, in Study 1A and 1B, we found that participants were more accurate at recognizing the intense and subtle micro-expressions of their racial outgroups than those micro-expressions of their racial ingroups, and neither the training experience nor the duration of micro-expressions moderated this ingroup disadvantage. In Study 2A and 2B, we further found that mere social categorization alone was sufficient to elicit the ingroup disadvantage for the recognition of intense and subtle micro-expressions, and such an effect was also unaffected by the duration of micro-expressions. These results suggest that individuals spontaneously employ the social category information of others to recognize micro-expressions, and the ingroup disadvantage in micro-expression stems partly from motivated differential processing of ingroup micro-expressions.
Trajectories and predictors of social avoidance in female patients with breast cancer
Authors: He Chunyan , Wu Chao , Yang Tianqi , He Yang , Yan Jiaran , Lin Yawei , Du Yanling , He Shizhe , Wu Shengjun , Cao Baohua
Published: November 2022

Background

Social avoidance plays an important role in influencing quality of life among patients with breast cancer. Social avoidance behaviors change with treatment periods. However, the trajectory patterns and the predictive factors have not been fully studied.

Objective

This study examined the growth trajectory of social avoidance and its predictors in patients with breast cancer.

Materials and methods

A total of 176 patients with breast cancer in a university hospital in Shaanxi Province, China, were followed up four times over 6 months following surgery, and data from the final 144 patients were analyzed. The growth mixed model (GMM) was used to identify the trajectory categories, and the predictive factors of the trajectory types were analyzed by logistic regression.

Results

The best-fit growth mixture modeling revealed three class models: persistent high social avoidance group (Class 1), social avoidance increased first and then decreased group (Class 2), and no social avoidance group (Class 3), accounting for 13.89, 31.94, and 54.17% of patients, respectively. Single-factor analysis showed that family income per capita, residence, and temperament type were related to the social avoidance trajectory. Logistic regression analysis showed that only temperament type was an independent predictor of the social avoidance trajectory, and patients with melancholia were more likely to have persistent high social avoidance.

Conclusion

Our study proved the heterogeneity of social avoidance behaviors and the influencing effect of temperament type on the development of social avoidance behaviors in Chinese patients with breast cancer. Health professionals should pay more attention to patients who are at higher risk of developing a persistent social avoidance pattern and provide target interventions.
Low-level EMF effects on wildlife and plants: What research tells us about an ecosystem approach
Authors: Levitt B. Blake , Lai Henry C. , Manville Albert M.
Published: November 2022

There is enough evidence to indicate we may be damaging non-human species at ecosystem and biosphere levels across all taxa from rising background levels of anthropogenic non-ionizing electromagnetic fields (EMF) from 0 Hz to 300 GHz. The focus of this Perspective paper is on the unique physiology of non-human species, their extraordinary sensitivity to both natural and anthropogenic EMF, and the likelihood that artificial EMF in the static, extremely low frequency (ELF) and radiofrequency (RF) ranges of the non-ionizing electromagnetic spectrum are capable at very low intensities of adversely affecting both fauna and flora in all species studied. Any existing exposure standards are for humans only; wildlife is unprotected, including within the safety margins of existing guidelines, which are inappropriate for trans-species sensitivities and different non-human physiology. Mechanistic, genotoxic, and potential ecosystem effects are discussed.
Is altitude a determinant of the health benefits of nature exposure? A systematic review and meta-analysis
Authors: Kim Eunsoo , Park Sujin , Kim Soojin , Choi Yeji , Cho Jae Hyoung , Kim Geonwoo
Published: November 2022

Introduction

Nature exposure is a widely accepted option for promoting public health owing to the recent surge of scientific evidence. However, the actual settings to facilitate this initiative is yet to be extensively reviewed. In this systematic review, we have aimed to provide an up-to-date summary of interventional studies investigating the psycho-physiological effects of forests and urban forests, including details on their physical settings, and investigate an effect-modifying role of altitude and summarize data on the magnitude and shape of the association.

Methods

A keyword search using five electronic academic databases (PubMed, Embase, PsycINFO, Web of Science, and Scopus) was conducted to identify relevant articles published in English from the inception year to the end of February 2022. The methodological quality was evaluated using the ROBINS-I or ROB2 tool, depending on the study design. Meta-regression and random effects model were jointly used to examine the relationship between altitude and health outcomes.

Results

We included 27 eligible studies and 31 cases extracted from 19 studies were used for the meta-analysis. In the meta-regression, we observed a non-linear association between altitude and psycho-physiological effects. Altitude had a positive quadratic association with anxiety (p < 0.000, adjusted R2 = 96.79%), depression (p < 0.000, adjusted R2 = 98.78%), and fatigue (p < 0.000, adjusted R2 = 64.74%) alleviating effects. Conversely, altitude demonstrated a negative non-linear association with the blood pressure-lowering effect (p = 0.009, adjusted R2 = 32.83%). Additionally, the thermal index (THI) and illuminance (lx) levels were significantly associated with effect sizes of psychological restoration.

Discussion

This review provides moderate-certainty evidence for an effect-modifying role of altitude. The meta-regression results suggested the optimal and minimal altitude ranges for psychological restoration and physiological relaxation, respectively. Despite some limitations, the study findings provide a significant basis for utilizing altitude, which is easily accessible and simple, to promote the health benefits of nature-based initiatives.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022310894, identifier: CRD42022310894.
Innovation and financial sustainability in China's long-term care insurance: An empirical analysis of the Nantong pilot
Authors: Guo Peng , Li Yajun
Published: November 2022

Background

Against a backdrop of aging and declining birthrates, the demand for long-term care insurance (LTCI) systems in various countries throughout the world continues to rise. Most traditional LTCI systems only cover a limited group of people, which cannot solve the problem of nursing needs among other groups, and, further, it makes financial sustainability very difficult to achieve.

Purpose

This article aims to explore how Nantong successfully achieves both “full coverage” and “financial sustainability” through institutional innovation.

Objects

Institutional innovation logic and financial sustainability of LTCI system in Nantong, one prefecture-level city with the highest degree of aging in China.

Methods

Through field interviews and research, this article examines the LTCI system in Nantong, exploring its logic and its successful realization of institutional innovation, which combines international and local experience. The study further uses quantitative methods to measure the system's financial sustainability.

Data

From the seventh national population census bulletin, the 13th Five-Year population development plan, the Nantong Municipal Bureau of Statistics and Nantong Statistical Yearbook 2020 from Nantong government. And from the authors' field survey data in the Medical Insurance Bureau of Nantong.

Results

The findings reveal that the Nantong model effectively disperses institutional risks by means of horizontal and vertical transfer payments, diversified financing, and service outsourcing, achieving its dual goals of full coverage and financial sustainability in the long run.

Conclusion

Nantong Model has interrupted the path dependence of traditional dual systems and the philosophy of fragmented institutional construction. Nantong's path-breaking institutional construction paradigm has important theoretical and practical value.

Contributions

The experience of Nantong may prove valuable and instructive, for not only other cities in China but also developing countries across the globe.
The trend in exclusive breastfeeding practice and its association with maternal employment in Bangladesh: A multilevel analysis
Authors: Ahmmed Foyez , Hossain Md. Jamal , Sutopa Tasmiah Sad , Al-Mamun Md. , Alam Morshed , Islam Md. Rabiul , Sharma Rohit , Sarker Md. Moklesur Rahman , Azlina Mohd Fahami Nur
Published: November 2022

Exclusive breastfeeding (EBF) is essential for infant and child health. This study aimed to explore the trend in the EBF over the last decade in Bangladesh and investigated if there was a significant association with maternal employment by analyzing the data extracted from three consecutive nationally representative surveys: Bangladesh Demographic and Health Surveys (BDHS) of 2011, 2014, and 2017–2018. Prevalence of EBF (95% confidence interval) with the Cochran-Armitage test was reported to see the trend in EBF. A chi-square (χ2) test was applied to find the potential factors associated with EBF. Finally, a three-level logistic regression was utilized to find the significant association between maternal employment and EBF while adjusting other covariates. We observed no increase in the practice of EBF over the last decade (P = 0.632). The prevalence of EBF was 64.9% (95% CI: 61.41, 68.18) in 2011, followed by 60.1% (95% CI: 56.25, 64) in 2014, and 64.9% (95% CI: 61.82, 67.91) in 2017. Regression results showed that employed mothers had 24% (p < 0.05) lower odds of EBF than unemployed mothers. Early initiation of breastfeeding was also found to be significantly associated [Adjusted odds ratio (AOR): 1.22, P < 0.05] with EBF. Government and policymakers must come forward with new interventions to increase the practice of EBF, providing basic education and campaigns on the topic of EBF. Maternity leave should be extended up to 6 months of the child's age to achieve an optimal level of EBF.
Phytoremediation potential of indoor plants in reducing air pollutants
Authors: Ravindra Khaiwal , Mor Suman
Published: November 2022

Indoor air quality (IAQ), specifically after the COVID-19 pandemic, has become an international issue, as humans spend 80–90% of their time in indoor microenvironments. Poor IAQ has been related to the sick-building syndrome, nasal and ocular irritations, allergies, and respiratory dysfunction, including premature deaths. Phytoremediation is a novel strategy to absorb, adsorb, assimilate or transfer/reduce air pollutants and improve the IAQ using plants. Hence, the current review aims to explore indoor plants' role in improving indoor air quality, including their purification capabilities. There is increasing evidence that various plant species (e.g., Ficus benjamina, Chlorophytum comosum, Draceana) or their parts can reliably reduce the concentration of numerous air pollutants in the indoor microenvironment and promote human wellbeing. However, the indoor air pollutants removal efficiency depends on the species of plant, various plant characteristics such as leaf size, thickness, area, photosynthetic activity, light intensity and part of plant involved, i.e., roots, leaves, wax, cuticle and stomata. Using indoor plants is one of the most cost-effective and reliable methods of making a healthier indoor environment. Better public health can be maintained at a lower cost, with less strain on the health care system, if more emphasis is placed on creating a biophilic atmosphere and increasing the use of indoor plants. However, there are no established criteria for the best indoor plants and the impact of indoor plants on various factors such as interior ventilation, temperature, humidity, etc. Therefore, further experimental research is needed that simulates the interior environment to monitor the impacts of indoor plants on factors such as humidity, temperature, ventilation, etc., in improving the microenvironment of a closed space/room.
The perceived built environment and general physical activity: An exploratory study in Jordan
Authors: Saadeh Rami , Obaidat Ahmed , Allouh Mohammed Z.
Published: November 2022

Introduction:

The built environment affects the health and wellbeing of the population. The main purpose of this study was to explore the association between the perceived built environment and general physical activity among Jordanians.

Methods

This cross-sectional study was conducted in Jordan between August and November of 2019 using an online self-administered questionnaire distributed to Facebook groups that are commonly used among the Jordanian population. Descriptive statistics using chi-square test of independence was used to examine the relationship between demographic information and the perceived built environment with physical activity.

Results and discussion

A total of 1,124 participants were involved in the study with the majority being middle-aged (91.5%), females (67.7%), undergraduates (68.1%), and living in urban areas (71.2%). Most study participants (68.2%) were neither physically active ‘at least two times per week' nor using parks for routine physical activity (82.5%). Regarding the association of demographic information with physical activity, gender was significantly associated with weekly physical activity, whereas age and monthly income were significantly associated with routine walking or biking. Further, on the one hand, gender, residency, and monthly income were significantly associated with physical activity at the park (p ≤ 0.05). On the other hand, the availability of specific biking paths, having good and accessible places for physical activity, was among the built environment factors that were significantly associated with weekly physical activity (p ≤ 0.05). Some characteristics of the perceived built environment were associated with physical activity. Therefore, enhancing the built environment is considered a cornerstone in any national health behavior plan that includes physical activity as one of its components.