bluuebunny/crossref_metadata_2025 huggingface dataset:
Constrained Static/Dynamic Economic Emission Load Dispatch Using Elephant Herd Optimization
Authors: Peesapati Rajagopal , Nayak Yogesh Kumar , Warungase Swati K. , Salkuti Surender Reddy
Published: June 2023

The rapid growth in greenhouse gases (GHGs), the lack of electricity production, and an ever-increasing demand for electrical energy requires an optimal reduction in coal-fired thermal generating units (CFTGU) with the aim of minimizing fuel costs and emissions. Previous approaches have been unable to deal with such problems due to the non-convexity of realistic scenarios and confined optimum convergence. Instead, meta-heuristic techniques have gained more attention in order to deal with such constrained static/dynamic economic emission load dispatch (ELD/DEELD) problems, due to their flexibility and derivative-free structures. Hence, in this work, the elephant herd optimization (EHO) technique is proposed in order to solve constrained non-convex static and dynamic ELD problems in the power system. The proposed EHO algorithm is a nature-inspired technique that utilizes a new separation method and elitism strategy in order to retain the diversity of the population and to ensure that the fittest individuals are retained in the next generation. The current approach can be implemented to minimize both the fuel and emission cost functions of the CFTGUs subject to power balance constraints, active power generation limits, and ramp rate limits in the system. Three test systems involving 6, 10, and 40 units were utilized to demonstrate the effectiveness and practical feasibility of the proposed algorithm. Numerical results indicate that the proposed EHO algorithm exhibits better performance in most of the test cases as compared to recent existing algorithms when applied to the static and dynamic ELD issue, demonstrating its superiority and practicability.
Assessing Cardiac Functions of Zebrafish from Echocardiography Using Deep Learning
Authors: Huang Mao-Hsiang , Naderi Amir Mohammad , Zhu Ping , Xu Xiaolei , Cao Hung
Published: June 2023

Zebrafish is a well-established model organism for cardiovascular disease studies in which one of the most popular tasks is to assess cardiac functions from the heart beating echo-videos. However, current techniques are often time-consuming and error-prone, making them unsuitable for large-scale analysis. To address this problem, we designed a method to automatically evaluate the ejection fraction of zebrafish from heart echo-videos using a deep-learning model architecture. Our model achieved a validation Dice coefficient of 0.967 and an IoU score of 0.937 which attest to its high accuracy. Our test findings revealed an error rate ranging from 0.11% to 37.05%, with an average error rate of 9.83%. This method is widely applicable in any laboratory setting and can be combined with binary recordings to optimize the efficacy and consistency of large-scale video analysis. By facilitating the precise quantification and monitoring of cardiac function in zebrafish, our approach outperforms traditional methods, substantially reducing the time and effort required for data analysis. The advantages of our method make it a promising tool for cardiovascular research using zebrafish.
D0L-System Inference from a Single Sequence with a Genetic Algorithm
Authors: Łabędzki Mateusz , Unold Olgierd
Published: June 2023

In this paper, we proposed a new method for image-based grammatical inference of deterministic, context-free L-systems (D0L systems) from a single sequence. This approach is characterized by first parsing an input image into a sequence of symbols and then, using a genetic algorithm, attempting to infer a grammar that can generate this sequence. This technique has been tested using our test suite and compared to similar algorithms, showing promising results, including solving the problem for systems with more rules than in existing approaches. The tests show that it performs better than similar heuristic methods and can handle the same cases as arithmetic algorithms.
The Role of Ascorbate–Glutathione System and Volatiles Emitted by Insect-Damaged Lettuce Roots as Navigation Signals for Insect and Slug Parasitic Nematodes
Authors: Laznik Žiga , Križman Mitja , Zekič Jure , Roškarič Mihaela , Trdan Stanislav , Urbanek Krajnc Andreja
Published: June 2023

The effect of wireworm-damaged lettuce roots on the antioxidative defense system (ascorbate–glutathione cycle, photosynthetic pigments) and movement of insect/slug parasitic nematodes towards determined root exudates was studied in a glasshouse experiment. Lettuce seedlings were grown in a substrate soil in the absence/presence of wireworms (Elateridae). The ascorbate–glutathione system and photosynthetic pigments were analyzed by HPLC, while volatile organic compounds (VOC) emitted by lettuce roots were investigated by GC-MS. Herbivore-induced root compounds, namely 2,4-nonadienal, glutathione, and ascorbic acid, were selected for a chemotaxis assay with nematodes Steinernema feltiae, S. carpocapsae, Heterorhabditis bacteriophora, Phasmarhabditis papillosa, and Oscheius myriophilus. Root pests had a negative effect on the content of photosynthetic pigments in the leaves of infested plants, indicating that they reacted to the presence of reactive oxygen species (ROS). Using lettuce as a model plant, we recognized the ascorbate–glutathione system as a redox hub in defense response against wireworms and analyzed its role in root-exudate-mediated chemotaxis of nematodes. Infected plants also demonstrated increased levels of volatile 2,4-nonadienal. Entomopathogenic nematodes (EPNs, S. feltiae, S. carpocapsae, and H. bacteriophora) proved to be more mobile than parasitic nematodes O. myriophilus and P. papillosa towards chemotaxis compounds. Among them, 2,4-nonadienal repelled all tested nematodes. Most exudates that are involved in belowground tritrophic interactions remain unknown, but an increasing effort is being made in this field of research. Understanding more of these complex interactions would not only allow a better understanding of the rhizosphere but could also offer ecologically sound alternatives in the pest management of agricultural systems.
iORandLigandDB: A Website for Three-Dimensional Structure Prediction of Insect Odorant Receptors and Docking with Odorants
Authors: Jin Shuo , Qian Kun , He Lin , Zhang Zan
Published: June 2023

The use of insect-specific odorants to control the behavior of insects has always been a hot spot in research on “green” control strategies of insects. However, it is generally time-consuming and laborious to explore insect-specific odorants with traditional reverse chemical ecology methods. Here, an insect odorant receptor (OR) and ligand database website (iORandLigandDB) was developed for the specific exploration of insect-specific odorants by using deep learning algorithms. The website provides a range of specific odorants before molecular biology experiments as well as the properties of ORs in closely related insects. At present, the existing three-dimensional structures of ORs in insects and the docking data with related odorants can be retrieved from the database and further analyzed.
Intraguild Prey Served as Alternative Prey for Intraguild Predators in a Reciprocal Predator Guild between Neoseiulus barkeri and Scolothrips takahashii
Authors: Liu Mingxiu , Wang Mian , Nima Yuzhen , Feng Xiaotian , Li Guangyun , Yang Yi , Li Yaying , Liu Huai
Published: June 2023

The predatory mites Neoseiulus barkeri (Hughes) and the predatory thrips Scolothrips takahashii (Priesner) are known as potential biocontrol agents for the two-spotted spider mite Tetranychus urticae (Koch). These two predator species occur simultaneously on crops in agricultural ecosystems and are proved to be involved in life-stage specific intraguild predation. The intraguild prey may play a role in securing the persistence of the intraguild predators during food shortage periods. To understand the potential of intraguild prey as food source for intraguild predators in the N. barkeri and S. takahashii guild at low T. urticae densities, the survival, development and reproduction of both predators was determined when fed on heterospecific predators. The choice tests were conducted to determine the preference of the intraguild predator between the intraguild prey and the shared prey. Results showed that 53.3% N. barkeri and 60% S. takahashii juveniles successfully developed when fed on heterospecific predators. Female intraguild predators of both species fed on intraguild prey survived and laid eggs throughout the experiment. In the choice test, both intraguild predator species preferred their extraguild prey T. urticae. This study suggested that intraguild prey served as an alternative prey for intraguild predators prolonged survival and ensured the reproduction of intraguild predators during food shortage, ultimately decreasing the need for the continual release of the predators.
Spent Coffee Grounds and Novaluron Are Toxic to Aedes aegypti (Diptera: Culicidae) Larvae
Authors: Thanasoponkul Waralee , Changbunjong Tanasak , Sukkurd Rattanavadee , Saiwichai Tawee
Published: June 2023

Aedes aegypti (Diptera: Culicidae) is a vector for mosquito-borne diseases worldwide. Insecticide resistance is a major concern in controlling this mosquito. We investigated the chemical compounds in wet and dry spent coffee grounds (wSCGs and dSCGs) and evaluated the efficacy of dSCGs, wSCGs, and novaluron on the mortality and adult emergence inhibition of Ae. aegypti. We found higher concentrations of chemical compounds in wSCGs than in dSCGs. The wSCGs and dSCGs both contained total phenolic compounds, total flavonoid compounds, caffeic acid, coumaric acid, protocatechuic acid, and vanillic acid. Complete mortality was observed after 48 h of exposure to 50 g/L wSCGs, while similar mortality was found after 120 h of exposure to 10 µg/L of novaluron. The sublethal dose was a concentration of wSCGs (5 g/L) and novaluron (0.01, 0.1, and 1 µg/L) combined that resulted in a larval mortality lower than twenty percent (at 72 h) to determine their synergistic effects. The death rate of larvae exposed in sublethal combination of wSCGs and novaluron was significantly higher than that of its stand-alone. The findings indicate that the combination of wSCGs and novaluron at sublethal concentrations had synergistic effects on the mortality of Ae. aegypti larvae and could be applied as an alternative control measure.
Varicocele: To Treat or Not to Treat?
Authors: Franco Antonio , Proietti Flavia , Palombi Veronica , Savarese Gabriele , Guidotti Michele , Leonardo Costantino , Ferro Fabio , Manna Claudio , Franco Giorgio
Published: June 2023

Varicocele treatment in infertility still remains controversial. It is clear, in fact, that in many patients, varicocele has no impact on fertility. Recent scientific evidence demonstrated that varicocele treatment is beneficial in improving semen parameters and pregnancy rate when an appropriate selection of patients is made. The purpose of treating varicocele in adults is mainly to improve current fertility status. On the other hand, the goal of treatment in adolescents is to prevent testicular injury and maintain testicular function for future fertility. Hence, the key to the success of varicocele treatment seems to be a correct indication. The aim of this study is to review and summarize current evidence in managing varicocele treatment focusing on the controversies regarding surgical indications in adolescent and adult patients, and in other specific situations such as azoospermia, bilateral or subclinical varicocele, and prior to ART.
Physical Health-Related Quality of Life Improves over Time in Post-COVID-19 Patients: An Exploratory Prospective Study
Authors: Malesevic Stefan , Sievi Noriane A. , Schmidt Dörthe , Vallelian Florence , Jelcic Ilijas , Kohler Malcolm , Clarenbach Christian F.
Published: June 2023

(1) Background: Ongoing symptoms after mild or moderate acute coronavirus disease 19 (COVID-19) substantially affect health-related quality of life (HRQoL). However, follow-up data on HRQoL are scarce. We characterized the change in HRQoL over time in post-COVID-19 patients who initially suffered from mild or moderate acute COVID-19 without hospitalization. (2) Methods: Outpatients who visited an interdisciplinary post-COVID-19 consultation at the University Hospital Zurich and suffered from ongoing symptoms after acute COVID-19 were included in this observational study. HRQoL was assessed using established questionnaires. Six months after baseline, the same questionnaires and a self-constructed questionnaire about the COVID-19 vaccination were distributed. (3) Results: In total, 69 patients completed the follow-up, of whom 55 (80%) were female. The mean (SD) age was 44 (12) years and the median (IQR) time from symptom onset to completing the follow-up was 326 (300, 391) days. The majority of patients significantly improved in EQ-5D-5L health dimensions of mobility, usual activities, pain and anxiety. Furthermore, according to the SF-36, patients showed clinically relevant improvements in physical health, whereas no significant change was found regarding mental health. (4) Conclusions: Physical aspects of HRQoL in post-COVID-19 patients relevantly improved over 6 months. Future studies are needed to focus on potential predictors that allow for establishing individual care and early interventions.
Assessment of Lipid Balance Parameters after Laparoscopic Sleeve Gastrectomy in 1-Year Observation
Authors: Pawłuszewicz Patrycja , Wojciak Paweł Andrzej , Łukaszewicz Aleksander , Chilmonczyk Jan , Ładny Jerzy Robert , Nadolny Klaudiusz , Razak Hady Hady
Published: June 2023

Introduction: Currently, the increase in the percentage of obese people observed along with the development of civilization, reaching the level of a global pandemic, has forced a search for methods of effective and permanent obesity treatment. Obesity is a multifactorial disease; it coexists with many disease entities and requires multidisciplinary treatment. Obesity leads to metabolic changes in the form of metabolic syndromes, which include, among others, atherogenic dyslipidemia. The proven relationship between dyslipidemia and cardiovascular risk enforces the need to effectively improve the lipid profile of obese patients. Laparoscopic sleeve gastrectomy is a method of surgical treatment of morbid obesity which improves bariatric and metabolic parameters. The aim of the study was to assess the effectiveness of laparoscopic sleeve gastrectomy (LSG) at improving lipid profile parameters upon a 1-year follow up. Material and Methods: Bariatric parameters of 196 patients who underwent laparoscopic sleeve gastrectomy as well as the lipid profile of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), non-NDL, and triglycerides (TG) in a 1-year observation were analyzed. Results: Improvements in bariatric parameters were observed in patients after LSG. Total cholesterol, low-density lipoprotein (LDL), triglycerides and non-HDL level decreases were observed along with an increase in high-density lipoprotein (HDL) cholesterol levels. Conclusions: Sleeve gastrectomy is an effective method of treating obesity and improving the lipid profile in obese patients.
Fetal Cerebellar Area: Ultrasound Reference Ranges at 13–39 Weeks of Gestation
Authors: Manzo Luigi , Orlandi Giuliana , Gabrielli Olimpia , Toscano Paolo , Di Lella Enrica , Lettieri Antonia , Mazzarelli Laura Letizia , Sica Giordana , Di Meglio Letizia , Di Meglio Lavinia , Ruffo Gabriele , Sica Carmine , Gulino Ferdinando Antonio , Incognito Giosuè Giordano , Tuscano Attilio , Giorno Alice , Di Meglio Aniello
Published: June 2023

Background and Objectives: The present study aims to provide prenatal 2-dimensional ultrasonographic (2D-US) nomograms of the normal cerebellar area. Materials and Methods: This is a prospective cross-sectional analysis of 252 normal singleton pregnancies, ranging from 13 to 39 weeks of gestation. The operator performed measurements of the fetal cerebellar area in the transverse plane using 2D-US. The relationship between cerebellar area and gestational age (GA) was determined through regression equations. Results: A significant, strong positive correlation was investigated between the cerebellar area with GA (r-value = 0.89), and a positive correlation indicates that with increasing GA, the cerebellar area increased in all the participants of the study. Several 2D-US nomograms of the normal cerebellar area were provided, and an increase of 0.4% in the cerebellar area each week of GA was reported. Conclusions: We presented information on the typical dimensions of the fetal cerebellar area throughout gestation. In future studies, it could be evaluated how the cerebellar area changes with cerebellar abnormalities. It should be established if calculating the cerebellar area in addition to the routine transverse cerebellar diameter may help in discriminating posterior fossa anomalies or even help to identify anomalies that would otherwise remain undetected.
Three-Dimensional Measurement of Proximal Humerus Fractures Displacement: A Computerized Analysis
Authors: Ripoll Thomas , Chelli Mikaël , Johnston Tyler , Chaoui Jean , Gauci Marc-Olivier , Vasseur Heloïse , Poltaretskyi Sergii , Boileau Pascal
Published: June 2023

Neer’s classification for proximal humerus fractures (PHFs) uses 10 mm and 45° thresholds to distinguish displaced fragments. While this system was originally developed referencing 2D X-rays, fracture displacements occur in three dimensions. Our work aimed to develop a standardized and reliable computerized method for measuring PHF 3D spatial displacements. CT scans of 77 PHFs were analyzed. A statistical shape model (SSM) was used to generate the pre-fracture humerus. This predicted proximal humerus was then used as a “layer” to manually reduce fragments to their native positions and quantify translation and rotation in three dimensions. 3D computerized measurements could be calculated for 96% of fractures and revealed that 47% of PHFs were displaced according to Neer’s criteria. Valgus and varus head rotations in the coronal plane were present in 39% and 45% of cases; these were greater than 45° in 8% of cases and were always associated with axial and sagittal rotations. When compared to 3D measurements, 2D methods underestimated the displacement of tuberosity fragments and did not accurately assess rotational displacements. The use of 3D measurements of fracture displacement is feasible with a computerized method and may help further refine PHF analysis and surgical planning.
The Early Effects on Tricuspid Annulus and Right Chambers Dimensions in Successful Tricuspid Valve Bicuspidization
Authors: Bieliauskienė Gintarė , Kažukauskienė Ieva , Janušauskas Vilius , Zorinas Aleksejus , Ručinskas Kęstutis , Mainelis Antanas , Zakarkaitė Diana
Published: June 2023

Background: It is unclear to what degree of tricuspid annulus (TA) reduction is necessary to achieve good postoperative results in surgical bicuspidization. The study aimed to evaluate TA and right heart chamber’s dimensions before and after heart surgery; and to compare TA parameters assessed by different modalities. Methods: Forty patients underwent mitral valve surgery with or without concomitant tricuspid valve (TV) bicuspidization. Preoperative and postoperative measurements of TA dimensions were performed prospectively using two-dimensional (2D) and three-dimensional (3D) transthoracic echocardiography (TTE). Additionally, preoperative transesophageal echocardiography (TOE) was performed in the operating room prior to surgery. Results: All patients had no or mild TR immediately after surgery. There was a significant reduction in 2D and 3D parameters of the TV and right chambers in the TV bicuspidization group. However, TV leaflets’ tethering parameters did not change significantly. Preoperative 3D TTE measurements were smaller than those obtained through 3D TOE in the operation room, before surgery under general anesthesia. The 2D systolic apical 4Ch diameter and the parasternal short axis diameter mainly represent the 3D minor axis of the TA and are smaller than its 3D major axis. Conclusions: Although bicuspidization results in a one-third reduction of the TV area, tethering of the TV leaflets remains unchanged. Moreover, 3D TOE parameters of the TV under general anesthesia are larger than preoperative 3D TTE measurements. Conventional 2D measurements are insufficient for evaluating the maximum diameter of the TA.
A Chair-Based Music–Kinetic Combined Exercise Program as an Alternative Approach for Increasing Health, Functional Capacity, and Physical Fitness Indices in Middle-Aged Pre-Menopausal Women
Authors: Karatrantou Konstantina , Papavasiliou Theodoros , Batatolis Christos , Vasilopoulou Theodora , Ioakimidis Panagiotis , Gerodimos Vassilis
Published: June 2023

Lately, chairs have been widely used as a cheap, easily accessible, safe, and effective training means in different settings (e.g., in gyms, the house, workplaces, and in rehabilitation). This study investigated the effectiveness of a 10-week chair-based music–kinetic integrated combined exercise program on health, functional capacity, and physical fitness indicators of middle-aged pre-menopausal women. A total of 40 healthy women (40–53 years) were assigned to two groups: exercise (EG) and control (CG). The EG followed a 10-week (3 times/weekly; 30 training sessions) chair-based exercise program including aerobic dance, flexibility, coordination, and strength exercises with body weight or auxiliary means. Selected indicators of health, functional capacity, and physical fitness were evaluated before and after the 10 weeks. Following the program, the EG significantly reduced their body fat (−2.5%), blood pressure (by −4.5 to −5.5%), the time during the timed up-and-go (TUG) test (by −10.27%), heart rate (by −6.35 to −13.78%), and the rate of perceived exertion (by −24.45 to −25.88%), while increasing respiratory function (3.5–4%), flexibility (12.17%), balance (50.38–51.07%), maximal handgrip strength (10–12.17%), and endurance strength (43.87–55.91%). The chair-based combined music–kinetic exercise program was effective and could be safely used in different settings to improve health, functional capacity, and physical fitness in middle-aged women.
Effects of Forest Management Approach on Carbon Stock and Plant Diversity: A Case Study from Karnali Province, Nepal
Authors: Lamsal Puspa , Aryal Kamal Raj , Adhikari Hari , Paudel Gayatri , Maharjan Surya Kumar , Khatri Dinesh Jung , Sharma Ram P.
Published: June 2023

The mitigation of global warming and conservation of biodiversity are two significant environmental challenges today. Estimating and comparing forest carbon stock and plant diversity under different management approaches provide insight into the choice of management approaches for carbon and plant diversity management. We investigated the variation in carbon stock and diversity of plant species in two forest managements under different approaches: the Kakrebihar protection forest (PF) and Sano Surkhet community forest (CF) in Karnali Province, Surkhet, Nepal. In total, 63 sample plots (30 plots in PF and 33 plots in CF) were laid out systematically across the forests. Dendrometric measurements were carried out for trees, poles, and saplings, and representative leaf litter and herb samples were collected. Soil samples were taken at 10 cm, 20 cm, and 30 cm depths using a soil auger. The existing tree volume equations of tree species of interest were used to estimate tree volume, and species-specific wood density and conversion factors were used to obtain total biomass and carbon content. Soil samples were analyzed using the Walkley-Black method to determine soil organic carbon. PF had higher carbon stock, plant species richness, and abundance at the landscape level than CF; however, the scenario differed at the plot level. At the plot level, PF had significantly higher total carbon stock and biomass carbon stock than CF. However, PF and CF were statistically indistinguishable in term of soil carbon stock. At the plot level, PF and CF were statistically indistinguishable regarding richness, Simpson diversity, and Shannon diversity, but PF had significantly higher plant abundance than CF. In conclusion, the value of PF for carbon stock and plant diversity surpassed those of CF. This study suggests that PF might be a better strategy to enhance carbon stock in forests and maintain habitat for various plant species.
Geographically and Ontologically Oriented Scoping of a Dry Valley and Its Spatial Characteristics Analysis: The Case of the Three Parallel Rivers Region
Authors: Zhang Linhao , Tang Haiping , Shi Peijun , Jia Wei , Dai Luwei
Published: June 2023

A dry valley is a special landscape type that is formed by the combined effect of climate and topography. Accurately defining the scope of a dry valley and knowledge of its spatial distribution characteristics can provide data support for relevant studies in the region. Starting from natural ontological characteristics and formation mechanisms, we constructed a geographical ontological model of dry valleys through an analysis of concepts related to the dry valley and combined GIS technology and methods to accurately define the scope and analyze the spatial characteristics of the dry valleys in the Three Parallel Rivers Region (DVT). Our results show that: (1) The geographically and ontologically oriented method developed to define the scope of the dry valley has a high accuracy, with an overall accuracy of 92.3% and a kappa coefficient of 0.84, therefore it can provide a better mechanism for defining the scope of a dry valley on a large scale. (2) The total area and total length of the DVT are 6147.1 km2 and 2125.3 km, respectively. The dry valleys in this region are mainly located in the Tibet Autonomous Region and in the Sichuan and Yunnan provinces in China. (3) The terrain in the DVT is precipitous, and areas with slopes greater than 25° account for 70% of the total area of the dry valleys. The DVT area of sunny aspects (north, northeast, and northwest aspects) is larger than that of shady aspects (south, southeast, and southwest aspects), and the land cover is mainly grassland with a desert substrate. The result of our study can provide data support for further in-depth research in related fields of dry valleys.
Effects of Trophic Acclimation on Growth and Expression Profiles of Genes Encoding Enzymes of Primary Metabolism and Plastid Transporters of Chlamydomonas reinhardtii
Authors: Puzanskiy Roman K. , Romanyuk Daria A. , Kirpichnikova Anastasia A. , Shishova Maria F.
Published: June 2023

In this paper, the effect of prolonged trophic acclimation on the subsequent growth of Chlamydomonas reinhardtii batch cultures was studied. The mixotrophic (light + acetate) acclimation stimulated subsequent growth at both mixotrophy and autotrophy conditions and altered the expression profile of genes encoding enzymes of primary metabolism and plastid transporters. Besides the trophic effect, the influence of Chlamydomonas culture growth stage on gene expression was determined. Under mixotrophic conditions, this effect was most pronounced in the first half of the exponential growth with partial retention of the previous acclimation period traits. The autotrophy acclimation effect was more complex and its significance was enhanced at the end of the growth and in the stationary phase.
Pancreatectomy and Pancreatic Surgery
Authors: Jabłońska Beata , Mrowiec Sławomir
Published: June 2023

Pancreatectomy, including pancreaticoduodenectomy (PD), as well as central pancreatectomy (CP), distal pancreatectomy (DP) and total/subtotal pancreatectomy, is a major, complex and difficult surgical procedure performed for various benign and malignant pancreatic diseases: from chronic pancreatitis, through benign cystic tumors and neuroendocrine neoplasms to malignant neoplasms, including pancreatic ductal adenocarcinoma (PDAC) [...]
Emergence of Echinococcus multilocularis in Central Continental Croatia: A Human Case Series and Update on Prevalence in Foxes
Authors: Balen Topić Mirjana , Papić Neven , Višković Klaudija , Sviben Mario , Filipec Kanižaj Tajana , Jadrijević Stipislav , Jurković Daria , Beck Relja
Published: June 2023

Human alveolar echinococcosis (HAE), caused by the metacestode stage of Echinococcus multilocularis, has emerged in many European countries over the last two decades. Here, we report the first data on the new HAE focus with increasing incidence in central Croatia, describe its clinical presentation and outcomes in diagnosed patients, and provide an update on the prevalence and geographic distribution of Echinococcus multilocuaris in red foxes. After the initial case in 2017 from the eastern state border, from 2019 to 2022, five new autochthonous HAE cases were diagnosed, all concentrated in the Bjelovar-Bilogora County (the county incidence in 2019 and 2021: 0.98/105, in 2022: 2.94/105/year; prevalence for 2019–2022: 4.91/105). The age range among four female and two male patients was 37–67 years. The patients’ liver lesions varied in size from 3.1 to 15.5 cm (classification range: P2N0M0–P4N1M0), and one patient had dissemination to the lungs. While there were no fatalities, postoperative complications in one patient resulted in liver transplantation. In 2018, the overall prevalence of red foxes was 11.24% (28/249). A new focus on HAE has emerged in central continental Croatia, with the highest regional incidence in Europe. Screening projects among residents and the implementation of veterinary preventive measures following the One Health approach are warranted.
Production and Internal Logistics Flow Improvements through the Application of Total Flow Management
Authors: Filipe Diana , Pimentel Carina
Published: June 2023

Background: Nowadays, as a result of globalization, markets are more competitive, and customers are more demanding. To respond to these challenges, organizations must develop mechanisms for continuous improvement in order to eliminate waste and increase the efficiency and effectiveness of processes. Thus, the present study carried out at an industrial unit responsible for the customization of cork stoppers for wines had as its main objectives to identify and eliminate or at least reduce waste; improve production and internal logistics flows; balance workloads; improve productivity; reduce lead time; motivate employees and promote the spirit of continuous improvement. Methods: The action-research methodology was used, whereby several cycles of data recovery and analysis, identification and implementation of opportunities for improvement, assessment and standardization were carried out. Therefore, the Total Flow Management (TFM) model was implemented, and several methods and tools were used, such as Value Stream Mapping (VSM), work measurement and 5S’s. Results: Several wastes and overloads were identified, and some actions were implemented, such as workload balancing, layout changes, implementation of visual management and supermarkets. That said, it was possible to reduce lead time by 4 days, improve productivity from 26.63 ML (a thousand cork stoppers)/h to 35.75 ML/h, and promote flexibility. In addition, employees were motivated, and a culture of continuous improvement was fostered. Conclusions: This project demonstrated that it is possible to implement improvement actions, with good results, without high investments, as well as motivating employees and taking advantage of their best capabilities. Additionally, it was demonstrated that the use of TFM can be very useful in continuous improvement, with evident improvements in production and internal logistics flows. So, this project demonstrated the practical implementation of TFM regarding basic reliability, production and internal logistics flow, and the simultaneous use of several methods and tools to implement continuous improvement. Thus, significant improvements were possible on the factory floor, as well as improving employee motivation their personal development and encouraging the focus on continuous improvement. Therefore, it responds to the gap identified in the literature.
(Decacarbonyl)(1-isopropyl-2-phenyl-1,2,5,6-tetrahydroacenaphtho [5,6-cd][1,2]diphosphole)ditungsten(0)
Authors: Davis Zachary H. , Carpenter-Warren Cameron L. , Taylor Laurence J. , Slawin Alexandra M. Z. , Kilian Petr , Chalmers Brian A.
Published: June 2023

A binuclear tungsten(0) complex with an asymmetric bridging 1,2-diphosphole ligand was prepared by the photolysis of tungsten hexacarbonyl in the presence of 1-isopropyl-2-phenyl-1,2,5,6-tetrahydroacenaphtho [5,6-cd][1,2]diphosphole. The tungsten complex 1 was characterized by high resolution mass spectrometry, multinuclear NMR spectroscopy (1H, 13C, 31P), and elemental microanalysis. The structure of the trans isomer was resolved by single crystal X-ray diffraction, showing a slight elongation of the P−P bond upon coordination to the W(CO)5 groups.
Channel Competition and Coordination of a Dual-Channel Supply Chain under Interval Demand
Authors: Tang Chunhua , Cao Erbao , Shi Zhanwen
Published: June 2023

Interval demand is becoming more common than ever before, since the variation bounds of uncertain demand are only required in practice, and they could be obtained through only a small amount of uncertain information. The goal of this paper is to analyze the optimal decision and coordination of a competitive dual-channel supply chain under an interval uncertain demand. For this purpose, we establish a centralized decision model and a wholesale price contract model under both interval demand and channel competition, respectively. Meanwhile, both the satisfaction degree of interval and the order relation of interval number are proposed to convert interval uncertain optimization problems to deterministic ones. Then, we derive the optimal pricing decisions, ordering quantities, and performances of partners and the supply chain system. Meanwhile, a revenue sharing contract is proposed to coordinate the competitive dual-channel supply chain under interval demand. Moreover, we found that the bounds of interval demand and channel sensitivities affect the optimal strategies and revenue sharing contract under interval uncertainty. Finally, we present a numerical analysis to illustrate the proposed results in this paper and conduct sensitivity analyses. The findings of this paper provide important references for decision makers and managers to make scientific decisions in an interval uncertain environment.
Deriving Euler’s Equation for Rigid-Body Rotation via Lagrangian Dynamics with Generalized Coordinates
Authors: Bernstein Dennis S. , Goel Ankit , Kouba Omran
Published: June 2023

Euler’s equation relates the change in angular momentum of a rigid body to the applied torque. This paper uses Lagrangian dynamics to derive Euler’s equation in terms of generalized coordinates. This is done by parameterizing the angular velocity vector in terms of 3-2-1 and 3-1-3 Euler angles as well as Euler parameters, that is, quaternions. This paper fills a gap in the literature by using generalized coordinates to parameterize the angular velocity vector and thereby transform the dynamics obtained from Lagrangian dynamics into Euler’s equation for rigid-body rotation.
Antioxidant Peptides from Monkfish Swim Bladders: Ameliorating NAFLD In Vitro by Suppressing Lipid Accumulation and Oxidative Stress via Regulating AMPK/Nrf2 Pathway
Authors: Wu Ming-Feng , Xi Qing-Hao , Sheng Yan , Wang Yu-Mei , Wang Wan-Yi , Chi Chang-Feng , Wang Bin
Published: June 2023

In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on an FFA-induced NAFLD model of HepG2 cells. The lipid-lowering mechanisms revealed that these five oligopeptides can up-regulate the expression of phospho-AMP-activated protein kinase (p-AMPK) proteins to inhibit the expression of the sterol regulatory element binding protein-1c (SREBP-1c) proteins on increasing lipid synthesis and up-regulating the expression of the PPAP-α and CPT-1 proteins on promoting the β-oxidation of fatty acids. Moreover, QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) can significantly inhibit reactive oxygen species’ (ROS) production, promote the activities of intracellular antioxidases (superoxide dismutase, SOD; glutathione peroxidase, GSH-PX; and catalase, CAT) and bring down the content of malondialdehyde (MDA) derived from lipid peroxidation. Further investigations revealed that the regulation of these five oligopeptides on oxidative stress was achieved through activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway to raise the expression levels of the heme oxygenase 1 (HO-1) protein and downstream antioxidant proteases. Therefore, QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) could serve as candidate ingredients to develop functional products for treating NAFLD.
Sesquiterpenes from Streptomyces qinglanensis and Their Cytotoxic Activity
Authors: Anh Cao Van , Kang Jong Soon , Yang Jeong-Wook , Kwon Joo-Hee , Heo Chang-Su , Lee Hwa-Sun , Park Chan Hong , Shin Hee Jae
Published: June 2023

Nine sesquiterpenes, including eight pentalenenes (1–8) and one bolinane derivative (9), were isolated from the culture broth of a marine-derived actinobacterium Streptomyces qinglanensis 213DD-006. Among them, 1, 4, 7, and 9 were new compounds. Their planar structures were determined by spectroscopic methods (HRMS, 1D, and 2D NMR), and the absolute configuration was established by biosynthesis consideration and electronic-circular-dichroism (ECD) calculations. All the isolated compounds were screened for their cytotoxicity against six solid and seven blood cancer cell lines. Compounds 4–6 and 8 showed a moderate activity against all of the tested solid cell lines, with GI50 values ranging from 1.97 to 3.46 µM.
The COVID-19 Pandemic Impact on the Psychophysical Health of Post-Menopausal Women: A Cross-Sectional Study
Authors: Lami Alessandra , Giacomelli Giulia , Lenzi Jacopo , Alvisi Stefania , Seracchioli Renato , Meriggiola Maria Cristina
Published: June 2023

Background and Objectives: The aim of this study was to investigate lifestyle, menopausal symptoms, depression, post-traumatic stress disorder (PTSD) and sleep disorders in post-menopausal women throughout the first wave of the COVID-19 pandemic, including the impact of menopause hormonal therapy (HT). Materials and Methods: Post-menopausal women were given the following questionnaires: socio-demographic characteristics; lifestyle; history of COVID-19; menopause-specific quality of life (MENQOL), the first part of which refers to the pre-pandemic period (“pre COVID-19”) and the second refers to the current period (“during COVID-19”); Beck’s depression inventory (BDI); the impact of event scale-revised (IES-R); and the Pittsburgh sleep quality index (PSQI). Results: One hundred and twenty-six women completed all questionnaires, with a mean age of 55.5 ± 6.0 years. The mean menopause duration was 5.7 ± 5.6 years. Twenty-four women were taking HT. A significant mean weight gain, a reduction in physical activity (respectively p < 0.001) and worsened quality of romantic relationships (p = 0.001) were reported during the pandemic. Menopausal symptoms did not vary significantly throughout the pandemic; however, women taking menopausal HT had lower physical (p = 0.003) and sexual (p = 0.049) MENQOL domain scores, lower depressive symptoms (p = 0.039) and better romantic relationships (p = 0.008). Conclusions: The COVID-19 pandemic caused reduced physical activity, worsened food habits and weight gain in post-menopausal women. They also reported a high rate of severe–moderate PTSD and a negative influence on their romantic relationships. Menopausal HT seems to be a potential protective factor for sexual and physical status and for symptoms of depression.
A De Novo 8q22.2q22.3 Interstitial Microdeletion in a Girl with Developmental Delay and Congenital Defects
Authors: Kalinauskiene Ruta , Brazdziunaite Deimante , Burokiene Neringa , Dirsė Vaidas , Morkuniene Ausra , Utkus Algirdas , Preiksaitiene Egle
Published: June 2023

Background and Objectives: Only nine patients with interstitial de novo 8q22.2q22.3 microdeletions have been reported to date. The objective of this report is to present clinical features of a new patient with an 8q22.2q22.3 microdeletion, to compare her phenotype to other previously reported patients, and to further expand the phenotype associated with this microdeletion. Materials and Methods: We describe an 8½-year-old girl with developmental delay, congenital hip dysplasia, a bilateral foot deformity, bilateral congenital radioulnar synostosis, a congenital heart defect, and minor facial anomalies. Results: Chromosomal microarray analysis revealed a 4.9 Mb deletion in the 8q22.2q22.3 region. De novo origin was confirmed by real-time PCR analysis. Conclusions: Microdeletions in the 8q22.2q22.3 region are characterized by moderate to severe intellectual disability, seizures, distinct facial features and skeletal abnormalities. In addition to one already reported individual with an 8q22.2q22.3 microdeletion and unilateral radioulnar synostosis, this report of a child with bilateral radioulnar synostosis provides additional evidence, that radioulnar synostosis is not an incidental finding in individuals with an 8q22.2q22.3 microdeletion. Additional patients with similar microdeletions would be of a great importance for more accurate phenotypic description and further analysis of the genotypic-phenotypic relationship.
Effect of Combined Electromagnetic Field and Plantar Flexion Resistance Exercise on Wound Healing in Patients with Venous Leg Ulcers: A Randomized Controlled Trial
Authors: Mohamady Heba Mohamed , Taha Mona Mohamed , Aneis Yasser M. , Aldhahi Monira I. , Attalla Asmaa Fawzy
Published: June 2023

Background and Objectives: Venous ulcers are recognized to be more painful and resistant to therapy than ulcers of other etiologies. Various methods have been used for the conservative treatment of venous ulcers, such as pulsed electromagnetic field (PEMF) and plantar exercise, which promote wound healing due to a range of physiological effects. The study aimed to examine the effect of combined pulsed electromagnetic field therapy and plantar flexion resistance exercise (PRE) on patients with venous leg ulcers (VLUs). Materials and Methods: The study was a prospective, randomized controlled trial. A total of 60 patients between the ages of 40 and 55 with venous ulcers were randomly assigned to 1 of 3 groups. For up to 12 weeks, the first group received PEMF therapy and plantar flexion resistance exercise (PRE) therapy in addition to conservative ulcer treatment for up to 12 weeks. The second group received only PEMF therapy in addition to conservative ulcer treatment, while the third group served as the control and received only conservative ulcer treatment. Results: At the four-week follow-up, the two experimental groups revealed a considerable variation in ulcer surface area (USA) and ulcer volume (UV), with no significant change in the control group. At the 12-week follow-up, there were significant differences between the three groups, while group A underwent the most significant changes, with mean differences at [95% confidence interval] of (−4.75, −3.82, −0.98) for USA and (−12.63, −9.55, −2.45) for UV, respectively. Conclusions: On a short-term basis, adding a plantar resistance exercise to the PEMF had no appreciable short-term effects on ulcer healing; however, their combination had more pronounced medium-term effects.
The “Viral” Form of Polyarteritis Nodosa (PAN)—A Distinct Entity: A Case Based Review
Authors: Pașa Victoria , Popa Elena , Poroch Mihaela , Cosmescu Adriana , Bacusca Agnes Iacinta , Slanina Ana Maria , Ceasovschih Alexandr , Stoica Alexandra , Petroaie Antoneta , Ungureanu Monica , Popa Andrei Emilian , Avram Raluca Ioana , Bologa Cristina , Poroch Vladimir , Coman Elena Adorata
Published: June 2023

Classic polyarteritis nodosa (PAN) is a vasculitis with systemic manifestations that is characterized by inflammatory and necrotizing lesions affecting medium and small muscular arteries, most frequently at the bifurcation of the vessels. These lesions lead to the formation of microaneurysms, hemorrhaging ruptured aneurysms, thrombosis, and, consequently, ischemia or organ infarction. Background and Objectives: We present a complex clinical case of a patient with a late diagnosis of polyarteritis nodosa with multiorgan involvement. Materials and Methods: The 44-year-old patient, in an urban environment, presented on her own in the emergency room for acute ischemia phenomena and forearm and right-hand compartment syndrome, requiring surgical decompression in the Plastic Surgery Clinic. Results: Significant inflammatory syndrome is noted, alongside severe normocytic hypochromic iron deficiency anemia, nitrogen retention syndrome, hyperkalemia, hepatic syndrome, and immunological disturbances: absence of cANCA, pANCA, anti Scl 70 Ac, antinuclear Ac, and anti dDNA Ac, as well as a low C3 fraction of the plasmatic complement system. The morphological aspect described in the right-hand skin biopsy correlated with the clinical data supports the diagnosis of PAN. Conclusions: The viral form of PAN seems to be individualized as a distinct entity, requiring early, aggressive medication.
A Low-Noise Interface ASIC for MEMS Disk Resonator Gyroscope
Authors: Zhang Wenbo , Yin Liang , Wang Yihang , Lv Risheng , Zhang Haifeng , Chen Weiping , Liu Xiaowei , Fu Qiang
Published: June 2023

This paper proposes a low-noise interface application-specific integrated circuit (ASIC) for a microelectromechanical systems (MEMS) disk resonator gyroscope (DRG) which operates in force-to-rebalance (FTR) mode. The ASIC employs an analog closed-loop control scheme which incorporates a self-excited drive loop, a rate loop and a quadrature loop. A ΣΔ modulator and a digital filter are also contained in the design to digitize the analog output besides the control loops. The clocks for the modulator and digital circuits are both generated by the self-clocking circuit, which avoids the requirement of additional quartz crystal. A system-level noise model is established to determine the contribution of each noise source in order to reduce the noise at the output. A noise optimization solution suitable for chip integration is proposed based on system-level analysis, which can effectively avoid the effects of the 1/f noise of the PI amplifier and the white noise of the feedback element. A performance of 0.0075°/√h angle random walk (ARW) and 0.038°/h bias instability (BI) is achieved using the proposed noise optimization method. The ASIC is fabricated in a 0.35 μm process with a die area of 4.4 mm × 4.5 mm and power consumption of 50 mW.
A Review of Phase-Change Materials and Their Potential for Reconfigurable Intelligent Surfaces
Authors: Matos Randy , Pala Nezih
Published: June 2023

Phase-change materials (PCMs) and metal-insulator transition (MIT) materials have the unique feature of changing their material phase through external excitations such as conductive heating, optical stimulation, or the application of electric or magnetic fields, which, in turn, results in changes to their electrical and optical properties. This feature can find applications in many fields, particularly in reconfigurable electrical and optical structures. Among these applications, the reconfigurable intelligent surface (RIS) has emerged as a promising platform for both wireless RF applications as well as optical ones. This paper reviews the current, state-of-the-art PCMs within the context of RIS, their material properties, their performance metrics, some applications found in the literature, and how they can impact the future of RIS.