bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic and predictive significance of VEGF, CD31, and Ang-1 in patients with metastatic clear cell renal cell carcinoma treated with first-line sunitinib
Authors: Kraljević Marija , Marijanović Inga , Barbarić Maja , Sokolović Emir , Bukva Merima , Cerić Timur , Buhovac Teo
Published: June 2022

The most common type of renal cell carcinoma (RCC) is clear cell renal cell carcinoma (ccRCC), which has a high metastatic potential. Even though the International Metastatic RCC Database Consortium (IMDC) risk model is conventionally utilized for selection and stratification of patients with metastatic RCC (mRCC), there remains an unmet demand for novel prognostic and predictive markers. The goal of this study was to analyze the expression of Vascular endothelial growth factor (VEGF), Cluster of Differentiation 31 (CD31) to determine microvessel density, and Angiopoietin-1 (Ang-1) in primary kidney tumors, as well as their predictive and prognostic value in patients with metastatic ccRCC (mccRCC) who were treated with first-line sunitinib. The study included 35 mccRCC patients who were treated with first-line sunitinib in period between 2009 and 2019. Immunofluorescence was used to examine biomarker expression in tissue specimens of the primary tumor and surrounding normal kidney tissue. Median disease-free survival (DFS) was longer in patients with negative and low tumor VEGF score than in patients with medium tumor VEGF score (p=0.02). Those with low tumor CD31 expression had a longer median DFS than patients with high tumor CD31 expression (p=0.019). There was no correlation between Ang-1 expression and DFS. The expression of biomarkers in normal kidney tissue was significantly lower than in tumor tissue (p<0.001). In conclusion, higher VEGF scores and greater CD31 expression were associated with longer DFS, but neither of these biomarkers correlated with progression-free survival or overall survival.
[RETRACTED] Iron Warrior Testo Thrust - Is It Another Scam or Legit? v1
Authors: Warrior Testo Thrust Iron
Published: June 2022

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[RETRACTED] Condor CBD Gummies Para Que Sirve Review v1
Authors: CBD Gummies Para Que Sirve Condor
Published: June 2022

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TheCondor CBD Gummies Para Que Sirveare made with CBD that comes from hemp. They are staggeringly famous, safe, and regular.
[RETRACTED] Ikaria Lean Belly Juice Australia v1
Authors: not provided Ikarialeanbelly
Published: June 2022

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Ikaria Lean Belly Juice Australia How Does Ikaria Lean Belly Juice Work? Ikaria Lean Belly Juice targets high uric corrosive and aggravation normally. These two are the genuine reasons for sub-optimal ability to burn calories. Uric corrosive is available in the human body. Purine nucleotides oversee it. The kidney and liver predominantly eliminate and channel uric corrosive from the body. The levels of this corrosive ascent when these organs referenced above don't work efficiently. What are the Ikaria Lean Belly Juice Ingredients? The Ikaria Lean Belly Juice Team is extremely straight-forward about the fixings. Each of these is normal and safe. The enhancement is liable for fostering the body's ideal digestion and right energy levels. Here are a portion of the dynamic fixings tracked down in Lean Belly Juice. Fucoxanthin: It is a well known digestion helping and weight reduction fixing. Fucoxanthin advances a protein that converts fat cells into intensity and energy. Therefore, it makes weight reduction simpler by empowering thermogenesis What are the Benefits of Ikaria Lean Belly Juice Supplement? Fat Burning: Ikaria's metabolic enhancement helps with adjusting digestion. It assists with transforming food into energy and not fats. Customary clients of the recipe experience less undesirable appetite torments and feel more satisfied. Moreover, the recipe is known to convey more grounded and brilliant skin and extra essentialness? http://www.bestsupplement24x7.com/supplemet/ikaria-lean-belly-juice-australia/ https://proton-4.jimdosite.com/ https://www.facebook.com/IkariaLeanBellyJuiceAustraliaAU/ https://the-dots.com/projects/ikaria-lean-belly-juice-australia-774691 https://www.spreaker.com/show/ikaria-lean-belly-juice-australia_2 https://www.pinterest.com/ikarialean/httpwwwbestsupplement24x7com/ https://www.linkedin.com/pulse/ikaria-lean-belly-juice-australia-tomy-zonmy/ https://medium.com/@tomyzonmy/ikaria-lean-belly-juice-australia-8d63e98387a3 https://tomyzonmy.clubeo.com/news/2022/06/07/ikaria-lean-belly-juice-australia?_ga=2.97570719.1841894455.1654614461-365148188.1654614459
[RETRACTED] Open Eye CBD Pain Relief Roller Reviews - 100% Fact Report About Ingredients and Price! v1
Authors: not provided reliefxroller
Published: June 2022

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(Limited Supplies) Click Here To Order Open Eye CBD Pain Relief Roller
PERCEPÇÕES DA TEORIA DA EVOLUÇÃO E SELEÇÃO NATURAL EM COMENTÁRIOS NO YOUTUBE
Authors: Tomaz Teixeira de Castro Higor , De Castro Moreira Ildeu , Massarani Luisa
Published: June 2022

RESUMO A teoria da evolução por meio da seleção natural, proposta independentemente por Charles Darwin e Alfred Wallace, um alicerce da ciência e da biologia moderna, motiva debates e percepções diversas. Neste estudo, tivemos como objetivo investigar a percepção da teoria da evolução por meio da seleção natural em comentários de vídeos com conteúdo em português, relacionados a esse tema, e disponíveis no YouTube. Nosso corpus consistiu em 24 vídeos, sendo selecionados aqueles com maior número de visualizações, a partir de uma busca pelas palavras-chave “teoria da evolução” e “seleção natural”. Os comentários foram submetidos à análise de conteúdo. A maior parte deles foi a favor da teoria da evolução. As vertentes de pensamento mais presentes nos comentários foram o darwinismo e o criacionismo, com o uso mais recorrente de argumentações de origem “científica” e “religiosa”, respectivamente. Conceitos como a ancestralidade comum, a seleção natural e o significado do termo “teoria” foram os principais responsáveis por suscitar embates nos comentários. Investigar a percepção da teoria da evolução em redes sociais, particularmente no YouTube, pode auxiliar na criação de novas estratégias no âmbito da divulgação científica, em particular nestes tempos de negacionismo, para que o tema possa ser melhor abordado por cientistas, divulgadores e educadores.
O SENTIDO DA RELIGIÃO EM RUBEM ALVES: UMA ANÁLISE A PARTIR DAS CIÊNCIAS DA RELIGIÃO
Authors: Dos Santos Roberto Magalhães
Published: June 2022

O presente artigo tem como objetivo fazer uma reflexão, sobre o sentido da religião no pensamento de Rubem Alves, mais especificamente em sua obra “O Enigma da Religião”, como contraponto a visão tradicional do sentido da religião. Estabelecendo assim a problemática sobre, qual o sentido da religião no pensamento de Rubem Alves. Assim, em um primeiro momento buscamos trazer a memória algumas informações relevantes sobre a obra a ser analisada, registrando alguns pontos importantes sobre o pensamento de Rubem Alves nesta obra. Logo após, apresentamos uma reflexão sobre o conceito tradicional de religião para que pudéssemos, contra apresentar o pensamento de Rubem Alves como contraposição do sentido tradicional da religião. Ressaltamos ainda sobre a importância da religião como parte social presentes nas mais diferentes culturas. Propomos enfim uma reflexão sobre a religião analisando o seu sentido dentro do pensamento de Rubem Alves, com especial destaque para a questão da religião como fruto da imaginação humana conforme a visão deste autor.
CONTEXTO CLÍNICO E SOCIAL DOS PACIENTES QUE ESCOLHERAM O TRANSPLANTE COMO TERAPIA RENAL SUBSTITUTIVA
Authors: Nascimento Francisco Elenilton Rodrigues do , Fraga Jamila Moura , Silva Ana Rosa Alves , Pereira Daíse Pinheiro , Studart Rita Mônica Borges
Published: June 2022

O transplante renal é modalidade de tratamento de saúde das pessoas com doença renal crônica, através da substituição de rim com funcionalidade deficiente por outro sadio. Os candidatos realizam preparação multiprofissional visando a apropriação pela equipe de saúde de aspectos clínicos, psíquicos e sociais visando minimizar situações possibilitem a perda do enxerto e, consequentemente, promovam a longevidade do órgão transplantado. Este trabalho tem por objetivo avaliar o contexto clínico e social dos pacientes que escolheram o transplante como terapia renal substitutiva. A pesquisa é um estudo descritivo, documental retrospectivo com abordagem qualitativa e de natureza exploratória. Utilizamos 185 prontuários aleatórios de pessoas que realizaram transplante renal, na modalidade doador falecido, entre janeiro de 2018 a junho de 2019 em hospital quaternário da cidade Fortaleza/CE. Foi formulado banco de dados em Planilha do Microsoft Excel e organizado pelos recursos estatísticos do software Programa Statistical Package for Social Sciences (SPSS). Entre os resultados encontrados destacamos a incidência dos participantes do gênero masculino; entre 18 a 59 anos de idade; de cor parda; de estado civil casado, oriundos do interior do estado Ceará; escolaridade de ensino médio; etiologia desconhecida e diabetes; e tempo de hemodiálise acima de 36 meses. A maioria exerce profissões/ocupações que não necessitam de elevados níveis de escolaridade. O estudo ressalta a importância do conhecimento das características da população atendida visando aperfeiçoar políticas públicas e a criação de novas frentes de atendimento cada vez mais eficientes e eficazes ante as necessidades dos usuários do Sistema Único de Saúde (SUS).
CIDADES INTELIGENTES, DESIGUALDADES SOCIAIS E DIREITOS HUMANOS: UMA ANÁLISE ACERCA DOS ASPECTOS DA NOVA ERA DIGITAL
Authors: Michele Santos Rocha Tayane , De Calasans Melo Andrade Diogo , Borges Vieira de Carvalho Grasielle
Published: June 2022

A evolução tecnológica concebeu uma “nova” sociedade em espaços cibernéticos. Em razão disso, sobreveio a possibilidade de recriar a ideia de cidade, como até então conhecida, para interconectar o espaço urbano ao espaço digital. As cidades inteligentes surgem da necessidade de melhorar o desenvolvimento econômico e o bem-estar social. O presente artigo pretende, a partir da teoria crítica e com base nos dados apresentados, desenvolver reflexões acerca do impacto de novas tecnologias na sociedade contemporânea, reconhecendo os seus aspectos positivos e negativos, num país onde os índices de desigualdade social, segundo o Mapa das desigualdades sociais 2020, são crescentes e as políticas públicas ineficientes. Assim, levanta-se a seguinte problemática: é possível pensar cidades inteligentes com níveis de desigualdades sociais tão alarmantes? Desse modo, o estudo baseia-se em pesquisa bibliográfica e estatística dotada de método qualitativo exploratório, com o objetivo de refletir as desigualdades sociais e geográficas no Brasil diante da evolução tecnológica.
A RESOLUÇÃO DE CASOS DIFÍCEIS A PARTIR DO PENSAMENTO DE NEIL MACCORMICK: A NECESSIDADE DA ANÁLISE DE PRECEDENTES DAS SUPREMAS CORTES DE NAÇÕES DEMOCRÁTICAS
Authors: Tempski Ferreira da Costa Daniel , Walter da Rosa Luísa
Published: June 2022

O intuito deste artigo é pesquisar a possibilidade de se aplicar os ideais de Neil MacCormick na resolução de casos difíceis de repercussão mundial, à luz da análise de precedentes das Supremas Cortes Democráticas. A importância do tema se dá pela necessidade de se fortalecer a interpretação e aplicação do Direito em face da Teoria Geral do Direito, bem como instituir uma verdadeira cultura dos precedentes, em especial em casos difíceis, garantindo-se assim a segurança jurídica. Para tanto, a partir do método dedutivo, com pesquisa bibliográfica, análise jurisprudencial e legislativa, num primeiro momento foi feito um diagnóstico tanto sobre os fundamentos da teoria de Neil MacCormick, quanto da utilização dos seus ensinamentos pelos Tribunais brasileiros. Em seguida, verificou-se a necessidade de se utilizar os seus conceitos para a aplicação e interpretação do Direito em casos difíceis julgados por nações diversas, com enfoque nos critérios da coerência e da universalidade. Após, partiu-se para uma proposta de necessidade de motivação judicial das decisões relacionada a conclusões de outras Cortes de países democráticos em casos idênticos. Por fim, como exemplo concreto, escolheu-se a discussão mundial a respeito da interceptação telemática de comunicações digitais dotadas de criptografia ponta a ponta, que, caso analisada sob o pensamento de MacCormick e respeitando precedentes, poderá servir como fonte de maior segurança jurídica, efetividade e imparcialidade nas decisões judiciais.
A URGÊNCIA DA (RE)AFIRMAÇÃO DO PACTO GLOBAL DE COMBATE ÀS ALTERAÇÕES CLIMÁTICAS
Authors: Bruno Flávio Marcelo , Leal Fraga Jonhanny Mariel , Pereira da Silva Matheus
Published: June 2022

O presente estudo propõe como tema de pesquisa, a determinação de que o clima é um direito fundamental essencial ao meio ambiente ecologicamente equilibrado. Determinando a urgência da (re)afirmação do pacto global de combate às alterações climáticas do Acordo de Paris. A pesquisa evidencia que há uma tendência elucidada na análise comparativa de políticas internacionais de combate às crises e alterações climáticas e em análises de casos recentes sobre litígios climáticos de que o Estado deveria dar uma contribuição adequada, maior do que sua contribuição atual, de modo a combater as mudanças climáticas e os perigos dela decorrente que comprometem o futuro da humanidade em razão da urgência no combate às alterações climáticas.
Experimental approach to obtaining subcutaneous xenograft of non-small cell lung cancer
Authors: Lukbanova E. A. , Mindar M. V. , Dzhenkova E. A. , Maksimov A. Yu. , Goncharova A. S. , Shatova Yu. S. , Maslov A. A. , Shaposhnikov A. V. , Zaikina E. V. , Lazutin Yu. N.
Published: June 2022

Purpose of the study. Was was the creation of a Patient Derived Xenograft (PDX) model of non‑small cell lung cancer in immunodeficient mice adapted to growth in immunodeficient mice.

Materials and methods. The study was performed using the tumor material from 14 donors implanted subcutaneously to 132 immunodeficient Balb/c Nude mice. Xenografts were maintained until the third passage. PDXs in the third passage from 3 patients were used to assess the model sensitivity to cisplatin. A histological analysis and genetic tests for the presence of EGFR mutations were performed for donor tumors from 3 patients and the corresponding xenografts in the third passage.

Results. We observed a noticeable PDX growth already on the 8th day after the tumor material implantation. Successful xenograft engraftment was noted in 21 of 42 mice (50 %), which were rather successful results. A comparative histological analysis of tumor material from 3 patients showed that the PDX models retained the original histotype. We also demonstrated the identity of the EGFR mutations in the established xenografts from 3 patients and the donor tumors, which proved the value of these PDX models for preclinical studies of substances with potential antitumor activity. The analysis of the xenograft sensitivity to cytostatic cisplatin showed a statistically significant decrease in the growth rate in the xenografts obtained from 2 out of 3 patients, in comparison with the control.

Conclusions. The created PDX models can be recommended as test systems for preclinical studies of the effectiveness of new pharmacological substances with potential antitumor activity.
Buccal ureteroplasty options, techniques, long-term results
Authors: Volkov A. A. , Budnik N. V. , Zuban O. N. , Mustapaev I. D. , Abdulaev M. A. , Muziev A. V.
Published: June 2022

Purpose of the study. Surgical treatment of extended strictures and obliterations of the ureter is still a complicated problem of modern urology. The aim of the study was to analyze our own experience of ureteral replacement plastic surgery with buccal graft, i.e buccal ureteroplasty (BU) with its extended strictures/obliterations.

Patients and methods. We’ve observed 25 patients who underwent BU. The lower third of the ureter was affected in 3 (12.0 %) cases, the lower third and the mouth of the ureter was affected in 7 people (28.0 %), the middle third in 2 (8.0 %), the upper third in 5 patients (20.0 %), the combined lesion of the upper third of the ureter and the pelvic‑ureteral segment (PUS) was in 8 (32.0 %) patients. All patients underwent repeated operations on a ureter, all revealed a significant comorbid background. The surgery was performed with a tubularized buccal graft in 13 (52.0 %), the onlay technique was applied in 12 (48.0 %). Laparoscopic surgery was performed in 10 (40.0 %) patients, surgical aid was carried out in an open way in 15 (60 %).

Results. Severe complications according to the Clavien‑Dindo classification, requiring hospitalization of patients in the intensive care unit with organ dysfunction, as well as lethal outcomes were absent. The follow‑up period of patients ranged from 1 to 57 months (an average of 14.7 months). One patient after laparoscopic BU with a tubular graft had a short (1 mm) stenosis in the anastomosis area for 6 months of follow‑up, which was successfully eliminated by laser endoureterotomy. During the entire follow‑up period, residual hydronephrosis was recorded in 4 patients (16.0 %) against the background of complete patency of the anastomosis. A control flexible ureteroscopy performed in 16 (64.0 %) patients did not reveal rejection of the buccal graft. There are still 20 patients under our supervision.

Conclusion. Our experience shows that the implementation of BU is possible on any part of the VMP using various techniques. This operation can be regarded as the "second" line of surgical treatment of strictures and obliterations of the ureter, especially after unsuccessful attempts of other reconstructions in a group of patients with severe concomitant pathology.
Prospects of the vacuum aspiration biopsy in terms of making the diagnoosis of malignant neoplasms of the mammary glands in patients categorised 3 and 4 according to BIRADS scale
Authors: Skurikhin S. S. , Bolotin I. A. , Chagunava O. L. , Guslev A. B.
Published: June 2022

Purpose of the study. Was to assess the prospects for the use of vacuum aspiration biopsy in terms of breast cancer diagnosis in patients with focal breast changes categorised by 3 and 4a according to the BIRADS scale.

Materials and methods. In the period from February 2020 to July 2021, 41 (n = 41) the patient with nodules of 3 and 4a categories according to BIRADS has been passed 41 vacuum aspiration biopsies (VAB) (n = 41) under local infiltration anesthesia with ultrasound navigation. The 17 % (n = 7) of the nodular neoplasms were represented by multiple lesions. The ultrasound examination was mandatory for all the patients and the 17 % (n = 7) was combined with mammography. Invasive diagnostics of tissue material from tumors subject to VAB was previously performed in 5 patients. Trephine biopsy was also performed in 4 cases and the fine needle aspiration biopsy (TAB) was performed in 1 case. Tissue atypia was not detected in all cases.

Results. The removed lesions were benign in 85.3 % (n = 35) of the cases. Breast cancer was diagnosed in 4.8 % of cases (n = 2), cancer in situ was diagnosed in 9.7 % (n = 4). The cases of invasive cancer were observed in both BIRADS categories, while in situ cancer was diagnosed in only 4a BIRADS categories. The residual tissue of the formation was detected in 1 case (n = 1). During the procedure, no complications were revealed. Moreover, in the early postoperative period, seroma formation has occurred in 2 patients 4.8 % (n = 2). All the patients noted the satisfactory tolerance to the manipulation.

Conclusion. The data obtained suggest that vacuum aspiration biopsy has a high diagnostic accuracy and certain advantages in this category of patients, in particular cases of urgent need to conduct more precise invasive diagnostics without performing the excisional biopsy examination.
TEKNOLOJİ GELİŞTİRME BÖLGELERİNDE FAALİYETTE BULUNAN İŞLETMELER AÇISINDAN BU BÖLGELERE YÖNELİK SAĞLANAN DEVLET TEŞVİK VE DESTEKLERİNİN DEĞERLENDİRİLMESİ: BİR TEKNOKENT ÖRNEĞİ
Authors: Onocak Derya , Köse Ömer , Onut Sefa
Published: June 2022

Bu çalışmanın amacı, teknoloji geliştirme bölgeleri (TGB)’ne yönelik uygulanan devlet teşvik ve desteklerinin bu bölgelerde faaliyet gösteren işletmeler açısından önemini ve işletmelerin bu bölgelerde faaliyette bulunma tercihleri üzerindeki etkisini tespit etmektir. Bu amaç kapsamında Cumhuriyet Teknokent’te faaliyette bulunan 57 firmadan 47’sine anket uygulanmıştır. “Tanımlayıcı bilgiler”, “TGB’lerde faaliyet göstermeyi etkileyen unsurlar”, “TGB’lere sağlanan teşvik ve desteklere yönelik düşünceler” olmak üzere üç farklı kategorideki soruların yer aldığı anket formu ile araştırmanın amacı kapsamında; akademisyen olan-olmayan, kadın-erkek, TGB dışında da faaliyette bulunan-bulunmayan katılımcıların görüşleri karşılaştırılmış ve anlamlı farklar tespit edilmiştir. Ayrıca katılımcıların çoğunun maliyetleri azaltıcı yönde etki eden en önemli destek unsurunun Katma Değer Vergisi (KDV) istisnası olduğu, teşvik politikalarının en önemli avantajının yeni yatırım düşüncelerini ortaya çıkarması olduğu, TGB’lerde şirket açmayı etkileyen en önemli unsurun sağlanan destekler ve teşvikler olduğu, teşvik ve desteklerin vergi yükünü azalttığı, yatırım yapmada kolaylık sağladığı ve sermaye ihtiyacını azalttığı yönünde görüşe sahip olduğu belirlenmiştir.
Impact of body mass index on the reliability of the CT0–4 grading system: a comparison of computed tomography protocols
Authors: Blokhin Ivan A. , Gonchar Anna P. , Kodenko Maria R. , Solovev Alexander V. , Gombolevskiy Victor A. , Reshetnikov Roman V.
Published: June 2022

BACKGROUND: The increased frequency of chest computed tomography utilization in the fight against COVID-19 has made usage of low-dose computed tomography necessary to reduce the radiation dose while preserving diagnostic quality. However, in the published literature, there were no data on the effect of body mass index on low-dose computed tomography accuracy in patients with COVID-19.
AIM: To assess the effect of patient body mass index on the level of agreement between radiologists interpreting standard-dose computed tomography and low-dose computed tomography in COVID-19-associated pneumonia using visual semiquantitative CT 04 scale.
MATERIALS AND METHODS: In this retrospective multicenter study, each participant underwent two consecutive chest scans at a single visit using standard-dose and low-dose protocols. Standard-dose and low-dose computed tomography with pulmonary and soft tissue kernels were interpreted using a visual semiquantitative CT 04 grading system. Data for each protocol were grouped by body mass index value (threshold value for pathology was equal to 25 kg/m2). Agreement was calculated based on binary and weighted classifications. One-way ANOVA analysis of variance was used to assess the presence of statistically significant differences in the mean for the groups.
RESULTS: Two hundred thirty patients met the established inclusion criteria for the study. The experts processed 4 studies for each patient: standard-dose and low-dose computed tomography with pulmonary and soft tissue kernels. The proportion of normal-weight patients was 31% (71 subjects), and the samples median body mass index was 27.5 (18.3; 48.3) kg/m2. There were no statistically significant differences in intergroup pairwise comparisons for both the binary and weighted classifications (p values were 0.09 and 0.12, respectively). The group of overweight patients was further subdivided according to the degrees of obesity; however, the results were invariant to this division (no statistically significant differences: for the most different body mass index groups normal and 3rd degree obesity p-value 0.17).
CONCLUSION: Body mass index does not affect chest standard-dose and low-dose computed tomography interpretation in COVID-19 using the visual semiquantitative CT 04 grading system.
ECOLOGICAL IMPACT OF WIND-DIESEL POWER PLANTS ON ECOSYSTEM AND POPULATION HEALTH
Authors: Sosnina E N , Masleeva O V , Shalukho A V , Lipuzhin I A
Published: June 2022

In electrification of the Eastern regions of Russia, an important part is assigned to the small-scale power distributed generation. In this regard, it is actual to construct wind-diesel power plants (WDPP), which impact on humans and environment is so far poorly studied. The results of a theoretical research of WDPP negative impact on health of the population and ecosystem of the territories of the East of Russia which were not covered by the centralized power supply have been given in the article. The assessment of indicators of atmospheric air pollution (specific and absolute values of the specified mass of annual emission of harmful substances, volumes of greenhouse gases emission, formation of acid rainfall, substances causing eutrophication) and physical pollution (noise, electromagnetic field) during use of WDPP of various rated capacity. Calculations have been done for 692 types of diesel engines and 97 models of wind power installations. The received results were compared with the level of environmental pollution during work of large thermal power plants. There have been given graphic dependences of the specified mass of the emitted harmful substances on power of the diesel engines, a noise level created by the wind power installations, on remoteness of settlements and power of the power installations, as well as a ratio of volume of harmful substances annual emission in the atmosphere during work of WDPP and the large thermal power plants. It has been shown that electrification of the Eastern regions of Russia on the basis of development of small-scale power distributed generation would have an ecological focus.
ANALYSIS OF DC-POTENTIAL LEVEL IN ASSESSMENT OF BODY FUNCTIONAL STATE (REVIEW)
Authors: Deputat I S , Nekhoroshkova A N , Gribanov A V , Bolshevidceva I L , Startseva L F
Published: June 2022

A review of modern scientific approaches to assessment of the brain energy metabolism by way of recording DC-potential levels has been presented in the article. A DC-potential level is a slowly varying steady potential of the millivolt range. It is one of the types of superslow physiological processes recorded between the brain and reference areas with use of DC amplifiers. It reflects individual characteristics of general and local energy consumption associated with the general brain and nervous system functional state. It has been underlined that the DC-potential level was a quantitative index of body current functional state that determined its physiological activity, presented activity of the neurophysiological mechanisms of permanent purpose supporting cerebral homeostasis in norm and regulating the functional hemispheric asymmetry. There have been shown views of domestic and foreign scientists on the nature of the DC-potential level and physiological patterns of the DC-potential level distribution. The dependence of the dynamics of the DC-potential level indices on the age influences and the cyclic mode of the body functionality has been described. It has been shown that the study of the DC-potential level helped to reveal mechanisms of interdependence of the brain energy metabolism and other body systems, to determine homeostasis features in changing environment, to assess probabilities of psychosomatic pathology and effectiveness of drug therapy. Particular attention has been paid to the analysis of possibilities of using the DC-potential level for establishment of relationships between the body functional activity and the brain energy metabolism and for practical development of new methods for diagnosis of different states.
IMPROVEMENT OF SURGICAL CARE MANAGEMENT IN PATIENTS WITH CLOSED ABDOMINAL INJURY ABOARD THE NAVY SHIPS
Authors: Mosyagin I G , Popov V A , Pleskach V V
Published: June 2022

The article includes an analysis of experience of surgical management in patients with closed abdominal injuries aboard the naval surface ships of the Navy of the USSR and the Russian Federation during long-distance voyages, and measures for improvement of surgical care management and treatment of the patients. It has been found that deaths because of wounds and closed abdominal injuries on the Soviet Navy ships were partly caused by late diagnosis, inaccurate assessment of the degree of blood loss, non-use of paracentesis at an advanced stage of care due to lack of surgical training of ship's doctors. To save positive results in future provision of surgical care to naval sailors during extended autonomous campaigns, there is needed an increase in the number of ship groups of specialized medical care (SGSMC) within the naval clinical hospitals of the fleets. This will allow to provide surgical care in a shorter time. An analysis of organization of surgical care of the Russian Navy ships personnel fulfilling tasks in the off-shore maritime zone and the ocean areas in 2012-2013 has shown the need for creation of additional 7 SGSMC: in the Northern Fleet - 2, in the Pacific Fleet - 2, in the Baltic fleet - 1, in the Black Sea Fleet - 1, in the Caspian Flotilla - 1. There has been proved the need to include staff anesthesiologists and paramedical anesthetists in these groups.
ECOLOGY OF MENTAL EPIDEMICS
Authors: Sidorov P I
Published: June 2022

Mental epidemics is a new phenomenon of integrative mentality medicine and singular progression. Mental epidemics are contagious polymodal and multiform mental disorders and conditions. The ground of mentality epidemiology is constituted by normative and permanent anomia and permissiveness of singular and crisis reality. There have been separated mechanisms of mental epidemics: deformation of conscience and identity, resonance and induction, anonymity and uncontrollability, generalization and expanded reproduction. There has been proposed a working classification of mental epidemics: dependent and induced, somatoform and psychosomatic, schizophrenia-related and schizoaffective disorders. There have been grounded the principles of a new paradigm of public health and public conscience adaptive protection from mental epidemics based on the synergetic biopsychosociospiritual methodology of mentality medicine as a new psychiatric paradigm of integrative medicine.
EVALUATION OF HAIR CHEMICAL COMPOSITION IN PATIENTS WITH CHRONIC SKIN DISEASES ON TERRITORY OF KHANTY-MANSI AUTONOMOUS OKRUG - YUGRA
Authors: Kravchenko I V , Pavlova E V , Sinelnikova Yu M , Rusak Yu E , Rusak S N , Murashko Yu A , Bashkatova Yu V
Published: June 2022

A comparative analysis of the trace elements content (Cr, Cu, Ni) in the hair of the surveyed groups of people with skin diseases and healthy persons (the control group) living in Surgut, the Khanty-Mansi Autonomous Area - Yugra, has been conducted. It has been determined, that the content of the trace elements in the hair of the groups of patients with dermatoses and healthy people differed significantly. It has been found that the content of the trace elements in the hair of the examinees with skin diseases compared to the control group was significantly higher. The Chrome concentration was the maximum.
PROBLEMS OF TRANSMERIDIAN FLIGHTS
Authors: Kiku P F , Khotimchenko M Yu , Nagirnaya L N
Published: June 2022

The presented review of scientific literature is devoted to biomedical research on the problem of transmeridian flights, as well as to search of ways of rapid overcome of desynchronosis occurring across time zones. It has been established that desynchronization of circadian oscillations of physiological functions after transmeridian flights was inevitable, the degree of its negative impact on the human body depended on individual biorhythms and can be corrected by proper choices of vital activity regime in the former and new time zones. The need in further research in the sphere of development and assessment of biological activity of the tools contributing to human rapid adaptation to changing time zones has been shown. One of the areas of research is development of means of correction based on preparations (and their components) of natural origin for optimization of functional state of bodies of humans after transmeridian flights who are ready to carry out their professional tasks in the shortest possible time.
PECULIARITIES OF EEG AND DC-POTENTIAL OF THE BRAIN IN NORTHERN SCHOOLCHILDREN
Authors: Dzhos Yu S , Nekhoroshkova A N , Gribanov A V
Published: June 2022

The article has presented the results of a study of the brain bioelectrical activity and cerebral energy exchange in 60 northern children aged 9-10 years (30 boys and 30 girls). Functional state of the central nervous system was assessed with use of electroencephalography and the method of the DC-potential recording. The results indicated that age development of the northern schoolchildren occurred in connection with adaptation to a complex of severe factors of the North and was characterized by lower frequency of alpha-rhythms and a higher level of theta - and delta-activities, especially in the frontal areas. It was accompanied by higher energy consumption of the brain in general and reduction of energy consumption in the frontal areas of the northern children compared to their peers in the central regions of Russia. These facts indicated relative immaturity of the brain and manifestations of functional stress associated with impact of adverse climatic and environmental conditions of the North on the children.
MENTAL TERRORISM OF HYBRID WARS AND ASYMMETRIC DEFENSE SYNERGETICS
Authors: Sidorov P I
Published: June 2022

In the article, the increased role of mental terrorism and mental weapons in contemporary hybrid wars has been proved. Fractal dynamics of development of destructive social epidemies of totalitarian cults as forms of mental terrorism has been separated via the model of scientology. Importance of international destructive sects and financial-cultic pyramids in deformation of public opinion has been shown. Attribution of scientological “auditors” to universal soldiers of the mental front of the Civilizational War has been grounded. There has been proposed a strategy of asymmetric response to the threat of global momentary drive in the form of development of hybrid neuro-bionic defense systems - inversion technologies uniting electronic-informational and biomedical, social-psychological and spiritual-moral resources of mentality ecology and mentality medicine. Tendencies of dispersion of the global security paradigm in the contemporary hybrid world have been separated, and the necessity of organization of an international scientific program “Mentality Ecology of Global Security” has been proved.
METHOD OF ASSESMENT OF LIVING STANDARDS AND SOCIOECONOMIC STATUS OF TB PATIENTS IN ARKHANGELSK REGION
Authors: Bogdanova E N , Balancev G A , Nikishova E I , Eliseev P I , Maryandyshev A O , Gospodarevskaya E , Squire S B
Published: June 2022

The article has described a unified methodology to assess the living standard and socioeconomic status (SES) of TB patients taking into account national and regional peculiarities and to work out approaches to further recovery of their living standard and improvement of their social well-being. This methodology is based on creating of the Integrated Welfare Index as a combination of monetary income, housing conditions and durable household assets as well as private estate to rank TB patients into three SES subgroups (absolutely, relatively poor and well-off). This methodology can be applicable to patients with other severe chronic diseases. The article has provided an example of approbation of this methodology in assessment of the SES of 112 patients with diagnosed MDR-TB in 2011-2012 in the Arkhangelsk region within the Project «PROVE IT LPA» of the International Union Against Tuberculosis and Lung Disease.
COMPARISON OF QUANTITATIVE DATA IN TWO PAIRED SAMPLES USING STATA SOFTWARE
Authors: Subbotina A V , Grjibovski A M
Published: June 2022

In this paper we have presented basic principles of analysis of quantitative data in two paired samples. Examples of normality testing, calculating paired t-test both manually and using the STATA software have been given. We have also considered assumptions for using paired t-test as well as the main principles of presentation of the results in scientific publications. The article has given only basic information on the use of t-test in research and it does not substitute reading specialized literature.
APPLICATION OF TELEMEDICINE TECHNOLOGIES IN NENETS AUTONOMOUS OKRUG
Authors: Karpunov A A , Basova L A , Kochorova L V , Martynovd N A
Published: June 2022

The article presents the peculiarities of telemedicine studios (TM) located in Nenets Autonomous Okrug (NAO). The activities’ analysis of TM studio at Nenets District Hospital was performed for the period of five years. A long-term target program “Development of telemedicine in NAO” contributing to equal rights realization in obtaining skilled and specialized medical care in remote areas of the Okrug has been launched since 2010. Its basis is the concept of sustainable evolution of indigenous peoples inhabiting the North of the Russian Federation. Under this program telemedicine technologies were widely used in the work of the District Hospital. In the analyzed period of time the number of scheduled and emergency TM consultations increased by 2-3 times.
MENTAL ECOLOGY OF THE EARLY PSYCHIC TRAUMA
Authors: Sidorov P I , Yakovleva V P
Published: June 2022

Fractal dynamics of the development of child’s early psychic traumas’ after-effects is described in the article. Predisposition fractals are marked out of a traumatogenic family, latent of pretraumatic diathesis, initial of functional disorders in the debut of a psychic trauma, a full-scaled clinical picture of the post-traumatic stress disorder, chronization of the personality post-reactive formation, the outcome of the personality disorders. The program of medico-psycho-socio-spiritual assistance was validated and the method of determination of early psychic traumas severity level was offered.
MATERNAL OCCUPATION AND MARITAL STATUS ARE ASSOCIATED WITH BIRTH WEIGHT AND RISK OF PRETERM BIRTH IN MONCHEGORSK (MURMANSK REGION) DURING A 30-YEAR PERIOD
Authors: Kozlovskaya A V , Odland J O , Grjibovski A M
Published: June 2022

We have studied social variations in the average birth weight and prevalence of preterm birth over a 30 year period based on data from the Kola Birth Registry (KBR) in Monchegorsk, we also have investigated associations between birth weight and preterm delivery and maternal occupation. Data on 24,602 infants born live from singleton pregnancies with birth weight above 1,000 grams and their mothers were abstracted inform the KBR. Associations between maternal occupation, marital status and birth weight and preterm birth have been studied. Multiple linear regression was used to quantify influences of independent variables of maternal characteristics on birth weight and preterm births. The multivariable logistic regression was applied to study independent associations between the studied factors and preterm births with and without adjustment to potential confounders. The babies born by the unmarried mothers were on the average 101 g (95% CI: -118, -84) lighter than the babies born by the married women. The women from all other occupations except machine operators, mechanical and trade workers had lighter babies compared to the women from the highest occupational category. The babies of the unmarried mothers were more likely to be born preterm (OR=1.73, 95% CI: 1.37, 2.19). Birth weight and risk of preterm delivery are connected with social factors, such as the mother’s occupation and her marital status, admittedly through the economic component.
BRAIN BIOELECTRICAL ACTIVITY IN NORTHERN CHILDREN AGED 9-10 YEARS BY DIFFERENT DAY LENGTH
Authors: Dzhos Yu S , Gribanov A V , Bagretsova T V
Published: June 2022

In the article, there have been given results of a study of the brain bioelectrical activity in primary school children in periods of increasing, maximum, decreasing and minimum day length. Amplitude and frequency dynamics of basic EEG rhythms has been described, and their interrelation with periods of natural illumination has been determined. It has been detected that adaptive tuning of the brain bioelectrical activity occurred in contrasting seasons. During the period of increasing day length, increasing activity of all EEG rhythms was observed, while in the period of decreasing day length, delta- and theta- activity in all regions of the brain dominated. It has been proved that the detected dynamics of amplitude and spectral-frequency EEG parameters in the northern schoolchildren aged 9-10 years was not caused by age-related changes. Periods of maximum and minimum day length can be considered more favorable for the brain functioning and development of higher mental functions of children.
VACCINATION AGAINST STR. PNEUMONIA AND INCIDENCE OF DISEASES IN CHILDREN LIVING UNDER COMBINED EFFECTS OF ANTHROPOGENIC LOAD AND IODINE DEFICIENCY
Authors: Dzhumagaziev A A , Raiskiy D V , Dzhalmuhamedova E I , Bezrukova D A
Published: June 2022

The monthly incidence of acute bronchitis, acute pneumonia and acute otitis media in orphanages’ children (192 children from 0 to 5 years old living under conditions of combined effects of anthropogenic stress and iodine deficiency) has been compared before and after immunization with pneumococcal vaccine to unvaccinated children, and according to 10-year statistical reports - to urban children of the same age groups constantly living in families. During 18 months of observation in two orphanages in babies groups (0-2 y. o.) immunized with pneumococcal conjugate vaccine, reduced incidence of acute respiratory diseases, acute bronchitis, decreased incidence of acute pneumonia and otitis media was noted. We have concluded that immunization against pneumococcus promoted the babies and children’s resistance.
SUBJECTIVE ASSESSMENT OF SURGICAL SPECIALTY CHOOSING FACTORS BY STUDENTS OF MEDICAL UNIVERSITY
Authors: Gaikina M Yu , Vasilyeva E Yu
Published: June 2022

This article has presented the results of the research aimed at studying the factors influencing a student’s choices of a job as a doctor, a medical institution and a doctor’s specialty during studies at the institution. The article has given a wide range of objective and subjective external and internal factors of a professional choice. It has been established that at the modern stage, subjective external factors, such as pedagogical competence of teaching staff of clinical departments in the sphere of pedagogical technologies studying conditions at clinical departments and teachers’ attitude to the problem of a professional choice dominated in the students’ choice of a “doctor” profession.
SIGNIFICATION OF MENTAL DYSAPTATION HIGH-RISK GROUP AMONG FIRST YEAR UNIVERSITY STUDENTS WITH DIFFERENT TYPES OF PERSONAL ACCENTUATIONS
Authors: Tyuryapina I V
Published: June 2022

The present research has described mutual influence of personality accentuations specific to certain students and failures in psychical adaptation to university conditions. According to the system approach to adaptation, which includes a psychological, socio-psychological, physiological components, we have studied the following aspects in the students with different accentuations: a level of psychic adaptation, social satisfaction, somatic health indicators, indicators of academic achievements. It has been established that the personalities with different accentuations were characterized by disorders of different components of the adaptation system. We have identified risk groups of adaptation among the students with personality accentuations. Types of accentuations with favorable prognosis of adaptation to university conditions have also been detected.
DESCRIPTIVE STATISTICS AND NORMALITY TESTING FOR QUANTITATIVE DATA
Authors: Subbotina A V , Grjibovski A M
Published: June 2022

In this article we explain types of data, main principles of testing for normality and descriptive statistics for quantitative data using Stata software. Using real examples, we present step-by-step analysis of data and presentation of descriptive statistics. This article continues a series of publications on basic biostatistics initiated in the previous issue of the journal. This series of papers can be used as a manual for analyzing the data from biomedical studies.
INTRODUCTION TO STATA - SOFTWARE FOR STATISTICAL DATA ANALYSIS
Authors: Unguryanu T N , Grjibovski A M
Published: June 2022

This is the first article of the series of publications in the Human Ecology journal on biostatistics using STATA software. Earlier series of methodological papers published in 2008 was adapted to SPSS software. However, the price for SPSS in Russia considerably increased in recent years that led to the fact that many institutions switch from SPSS to STATA. It is worth mentioning that STATA is as popular as SPSS in European universities and research institutions. Moreover, STATA has a broader range of advanced methods of data analysis. The authors are not aware of Russian textbooks on the use of STATA in biomedical research. This series is an attempt for a manual for Russian biomedical researchers on how to use STATA software.
CARDIOHEMODYNAMICS CAUSED BY CHANGES IN VENOUS RETURN TO HEART OF NORTHERNERS
Authors: Dernovoy B F , Irzhak L I
Published: June 2022

In basketball players (n = 7, the average age 22 years), linear velocity of blood flow through the aortic valve (Vlin), the heart beats (HB), stroke volumes (SV) and cardiac output (CO) increased in June as compared to February. Under the orthoclinotest, Vlin, SV and CO increased, HB decreased. Clinoorthotests caused a decrease in Vlin and SV.
STANDARDIZED METHODS FOR PREDICTING VIOLENCE OF PATIENTS UNDER COMPULSORY TREATMENT
Authors: Grigoryev I S , Denisov M F , Snedkov E V
Published: June 2022

In the article, use of standardized scales for predicting violence in forensic settings and their role in improving efficiency of compulsory treatment have been discussed.
EFFICIENCY OF SOLUTION OF VISUAL TASKS WITH VARIOUS DEGREES OF UNCERTAINTY IN SENSORY ENRICHED ENVIRONMENT
Authors: Astashchenko A P , Dorokhov E V , Yakovlev V N
Published: June 2022

In the article, there have been presented the results of audiostimulation effect as an environmental factor on psychophysiological parameters of personal decision making (time, errors) in young healthy subjects, as well as on autonomic parameters (heart rate) during visual identification of fragmented objects. Instrumental musical accompaniment with the rhythm of 60-70 beats per minute was more effective in solution of visual tasks under uncertainty. We suppose that it was associated with processes of increased synchronization of rhythmic activity in different areas of the brain and increased stress resistance. The reaction time of personal decision making and the number of correct answers were the main criteria of effectiveness of identification of fragmented visual stimuli in humans.
STATE OF COGNITIVE FUNCTIONS IN ABLE-BODIED MEN DRIVING MOTOR TRANSPORT
Authors: Prokopchuk N N , Skrebtsova N V , Popov V V
Published: June 2022

We have assessed cognitive functions in 103 able-bodied men (66 men were drivers; 37 men were in the control group, their profession was not connected with vibration). In each group, healthy patients and patients with arterial hypertension (AH) were separated. The cognitive functions were studied with use of the Montreal Cognitive Assessment Scale (MoCA-test). Cognitive disorders were found in 45.5 % of the drivers and in 29.7 % of the men from the control group. A correlation between the level of the MoCA-test index and the profession of the drivers has been found. Statistically significant between-group differences in the state of delayed memory, attention, orientation, verbal fluency of the drivers and the control group (with the significance level of p < 0.05) have been found.