bluuebunny/crossref_metadata_2025 huggingface dataset:
CURRENT STATE OF ENTREPRENEURIAL ACTIVITY OF UKRAINE
Authors:   Odessa National Economic University, Koshelek Halina
Published: February 2021

Carrying out business activities, enterprises ensure the development of the modern economy of the country, form the budget of different levels. Entrepreneurship itself forms an effective management system, is a requirement for achieving economic growth. The result of entrepreneurial activity is to make a profit. It is worth noting that experts provide contradictory assessments of the development of entrepreneurship in Ukraine. In the international ranking of ease of doing business Doing business-2020, Ukraine has taken 64th place, rising by 7 positions and improving 5 of the 10 key indicators. According to general statistics, there is a positive trend of growth of economic entities in recent years, but it does not provide growth in sales, this growth is accounted for by enterprises. It is self-employed entrepreneurs, who are the driving force of any country's economy, a means of overcoming the problems of low solvency and unemployment in the country. In the structure of economic entities in Ukraine by type of economic activity, the number of wholesale and retail trade enterprises and enterprises engaged in information and telecommunication activities is growing year after year, but the number of construction enterprises, transport enterprises, industrial enterprises, and agricultural enterprises is decreasing. The analysis of the cost structure by economic elements of Ukrainian enterprises showed that in general the largest share in the cost structure of business entities in Ukraine for the period from 2012 to 2019 is occupied by material costs. That is, the production of products (goods, services) is material-intensive and the country does not introduce innovative technologies. Due to the industrialization of the real sector of the economy, especially in manufacturing, the country has lost the complex types of production that provided the value chain. The result of such losses was the loss of entire sectors of complex exports and the stagnation of the real sector of the economy. As a result of provided research, it can be noted that there are certain problems in the country for the development of entrepreneurship, which is a special type of activity. The state should support small and medium-sized businesses in the country because entrepreneurship itself is a powerful "locomotive" that will make it possible to ensure proper growth of production and welfare. The prospect of further research should be the study of business engineering as a modern management technology that can significantly accelerate the reform of the domestic economy on a market basis.
THE ROLE OF INTERNATIONAL STRUCTURED FINANCING IN THE SYNDICATED LOAN OF UKRAINE
Authors:   Prydniprovska State Academy of Civil Engineering and Architecture, Varlamova Olga , Miahkova Viktoriia ,   Prydniprovska State Academy of Civil Engineering and Architecture
Published: February 2021

The article analyzes the main trends and parameters of the development of international structured financing for syndicated lending in Ukraine. Identified as one of the forms of international structuring of financing is a syndicated loan, which due to a number of characteristics performs in the world economy the function of an instrument for attracting investment capital and reducing or distributing risks. At the same time syndication of the credit allows not only to involve financial resources, but also to raise the image of the bank in the international markets. Banks gain such advantages as diversification of the resource base, flexible loan structure, reduction of transaction costs and more. The modern tendencies of using the syndicate as a tool of international structured financing are studied. The interrelation of the main conditions of integration of the banking system in the international financial market is determined. The ratio of advantages, risks and obstacles for further development of syndicated lending is considered. The relationship between the processes of syndicated lending and the rate of economic growth in Ukraine is revealed. Identified banks of Ukraine that have actively participated in syndicated lending over the past twenty years, taking into account the determined by the majority of implemented over the years and calculated the total amount of borrowed funds. To carry out the syndicated borrowing of the analysis, a sample was made according to the number, volume and periodicity that influenced the development of the country's international economic relations. Effective prerequisites for the formation of a functioning syndicated lending market in Ukraine have been identified. In the process of research, a model of syndicated lending in the national economy was built and a formula was developed according to which the amount is calculated when borrowing a syndicate. It is emphasized that the market entry of international structured finance through syndicated loans is becoming an increasingly important source of external financing in developing countries and plays a key role in the development and improvement of the economy by international standards. Foreign experience is analyzed as international structured financing is a factor in strengthening internalization, increasing economic growth and turning financial markets into the most important stimulus for the development of the international economy.
INCREASING INTERNATIONAL COMPETITIVENESS OF SMALL BUSINESS ENTERPRISES
Authors:   Prydniprovska State Academy of Civil Engineering and Architecture, Goncharova Katerina , Varlamova Olga ,   Prydniprovska State Academy of Civil Engineering and Architecture, Sorochynska Yuliia ,   Prydniprovska State Academy of Civil Engineering and Architecture
Published: February 2021

The article considers the main problems and directions of ensuring the international competitiveness of small businesses in the context of globalization. Today, the development of market relations creates a situation of pronounced competitive tension in almost all areas of business and for all forms of entrepreneurship, which requires adjustment of marketing strategy in order to purposefully strengthen the competitive position of Ukrainian small businesses in internationalization and create and use sustainable strategic advantages. competitive and tense marketing environment of the modern international market. The management of enterprises, realizing that it works in an internationalized market, thinks about the possibility of creating specific strategic advantages and original strategies that would contribute to the formation of a powerful potential for further production and commercial development of small enterprises. The analysis of competitive opportunities of Ukrainian enterprises must meet the requirements of strengthening international market positions and be carried out in terms of: definition of tasks and maturity of competitive behavior of subjects of competition; coordination of parameters of competitiveness at the level of product, company and country (region) and substantiation of international priorities of competition; construction of industry clusters to support the competitive position of individual enterprises; assessment of possible competitive risks based on the analysis of external and internal competition factors. Environmental factors determine opportunities, and the company creates the specifics of its own competitive behavior, assessing the level of competition in the industry, the presence of indirect competitors, the popularity of substitute products, the dominant methods of competition.
MODERN TRANSFORMATIONS OF THE WORLD MARKET OF PULP AND PAPER PRODUCTS
Authors:   Prydniprovska State Academy of Civil Engineering and Architecture, Orlovska Yulia , Synytskyi Stanislav ,   Prydniprovska State Academy of Civil Engineering and Architecture
Published: February 2021

The peculiarities of the development of the world pulp and paper industry have been considered in this study. The types of products are described and the traditional type of production process within the industry has been characterized. The main exporters of pulp and paper products in the world have been identified. The dynamics of production indicators for printing paper, pulp, chemical wood pulp, cardboard, coated paper in the world market has been analyzed. A review of the pulp and paper industry of Ukraine was carried out on the basis of indicators of export and import of pulp from wood or other fibrous materials, export-import balance, sales of pulp, paper and cardboard in domestic and foreign markets. The current trend in the dynamics of export-import balance in the bulk trade of wood or other fibrous pulp for the period 2016-2020 indicates a significant predominance of imports over exports, which can be attributed to the lack of positive developments in the segment of deep wood processing in the forest sector. The key factors of modern transformations of the world market of pulp and paper products are stated: the growing demand for viscose pulp products used in the manufacture of new types of plastics; growing demand for recycled paper in the context of environmental friendliness of the material; growth in demand for sanitary and hygienic types of paper, which is associated with the growth of income and population on a global scale; growing demand for packaging paper and cardboard as an ecological type of packaging material; falling demand for all types of sulfite cellulose due to the negative impact on the environment; falling demand for all types of writing paper due to the technological revolution and changes in the format of data storage as a result of digitalization processes. The global pandemic COVID-2019, the processes of digitalization and human development on the basis of the concept of sustainable development have been considered as the main drivers of transformation processes in the industry. The main priorities of development of enterprises of pulp and paper products in the conditions of modern transformations for the purpose of increase of the international competitiveness of industrial centers on the world arena have been specified.
Se la rappresentazione si autoavvera. Relazioni di co-evoluzione tra il territorio e la sua immagine
Authors: Balestrieri Mara , Cicalò Enrico
Published: February 2021

In questo articolo vengono discusse le reciproche relazioni tra rappresentazioni e processi territoriali e in particolare si evidenzia come le rappresentazioni, oltre a fotografare situazioni e trasformazioni in atto, siano in grado di influenzare l'evoluzione degli stessi processi rappresentati. Le rappresentazioni vengono aggiornate con l'evolversi delle forme dei territori così come le forme dei territori possono subire gli effetti dalle loro stesse rappresentazioni. Tra rappresentazione e soggetto territoriale rappresentato si delinea dunque un rapporto di co-evoluzione circolare, secondo il quale non solo il territorio agisce sulla sua rappresentazione ma anche la rappresentazione agisce a sua volta sul territorio rappresentato, rendendo ambivalente il ruolo della rappresentazione sia come conseguenza che come causa delle trasformazioni stesse.
Le politiche urbane per l'inclusione. Generare terzo spazio
Authors: Carrera Letizia
Published: February 2021

Oggi la città è più che in passato caratterizzata dalla multiculturalità, affrontata ancora con la logica del ‘melting pot', quindi di omogeneizzazione delle differenze, piuttosto che di quella più complessa della ‘salad bowl'. Uno strumento strategico è rappresentato dalla (ri)progettazione dello spazio urbano in vista della realizzazione di processi di inclusione, attraverso interventi strutturali puntuali e diffusi nel territorio. Centrali gli spazi terzi, spazi fisici nei quali soggetti diversi hanno la possibilità di incontrarsi e di iniziare percorsi di riconoscimento e di costruzione di comunità territoriali fondate sulle differenze e sulla contaminazione. Alcune politiche hanno optato per strategie di attesa di processi spontanei di composizione virtuosa di quelle differenze, altre per la messa in campo di azioni di governo delle differenze stesse e di processi di inclusione attiva.
The Impact of COVID-19 Cycling Infrastructure on Low-Stress Cycling Accessibility: A Case Study in the City of Toronto
Authors: Lin Bo , Chan Timothy C. Y. , Saxe Shoshanna
Published: February 2021

This paper investigates the impact of COVID-19 cycling infrastructure on Toronto’s low-stress cycling accessibility. We calculated the level of traffic stress (LTS) for the road network with and without the cycling infrastructure built in response to the COVID-19 pandemic. We then computed the accessibility to populations, jobs, food stores, and parks for each dissemination area at each LTS. We find that the COVID-19 cycling infrastructure increased low-stress population and job accessibility by 10.4% and 22.3% respectively, and granted food and park access to 54,023 and 3,178 people. Accessibility gains were largest in areas where new infrastructure linked with preexisting networks.
Pencapaian Perlaksanaan Program ODP di Malaysia (Achievement ODP Program Implementation in Malaysia)
Authors: Mustaffa Jamaludin , Ishak Noor Azniza
Published: February 2021

Pelbagai pendekatan telah dilakukan oleh Jabatan Penjara Malaysia sebagai institusi bertanggungjawab secara khusus dalam pemulihan banduan untuk membantu dalam membina kembali diri mereka agar dapat berperanan semula dalam masyarakat sama ada sebagai isteri, ibu, anak perempuan, kakak, pekerja, dan lain lain. Antara pendekatan diperkenalkan oleh Jabatan Penjara iaitu Sistem Parol yang memainkan peranan penting dalam memastikan banduan yang dibebaskan secara Parol dapat kembali kepada masyarakat sebagai seseorang yang berguna kepada negara dan mematuhi undang-undang yang sedia ada. Oleh itu artikel akan membincangkan mengenai sejauh manakah pencapaian perlaksanaan program Orang Di parol (ODP) yang dilaksanakan oleh Jabatan Penjara Malaysia khususnya di Bahagian Parol dan Perkhidmatan Komuniti berdasarkan kepada kajian yang dilakukan terhadap Pegawai Penjara (40 orang sampel) di bahagian tersebut. Hasil kajian menunjukkan tahap keberkesanan perlaksanaan Program ODP amat memberi kesan yang positif kepada ODP. Namun walaupun berkesan terdapat juga kelemahan-kelemahan dan cabaran-cabaran dalam perlaksanaan program ODP menurut responden. Oleh itu, pihak penjara perlulah sentiasa membuat penambahbaikan Sistem Parol dari masa ke semasa agar terus relevan dengan perubahan zaman supaya menjadi lebih komprehensif dan efesien. Abstract Various approaches have been taken by the Malaysian Prisons Department as an institution specifically responsible for the rehabilitation of prisoners to assist in rebuilding themselves so that they can play a role again in society whether as wives, mothers, daughters, sisters, employees, and others. Among the approaches introduced by the Prisons Department is the Parole System which plays an important role in ensuring that prisoners released by Parole can return to society as someone who is useful to the country and complies with existing laws. Therefore, the article will discuss the extent to which the implementation of the implementation of the ODP program implemented by the Malaysian Prisons Department, especially in the Parole and Community Services Division based on the study conducted on Prison Officers (40 people sample) in that division. The results show that the level of effectiveness of the implementation of the ODP Program has a very positive impact on the ODP. However, although effective, there are also weaknesses and challenges in the implementation of the ODP program according to the respondents. Therefore, the prison must constantly make improvements to the Parole System from time to time in order to remain relevant to the changing times to be more comprehensive and efficient. Keywords: ODP program, parole system, achievement.
Docetaxel for the adjuvant treatment of early nodepositive breast cancer: a single technology appraisal
Authors: Chilcott J , Jones M Lloyd , Wilkinson A
Published: February 2021

This paper presents a summary of the evidence review group (ERG) report into the clinical and cost-effectiveness of docetaxel for the adjuvant treatment of early node-positive breast cancer based upon the manufacturer’s submission to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal (STA) process. The manufacturer’s scope restricts the intervention to docetaxel in combination with doxorubicin and cyclophosphamide (TAC), and the comparator to anthracycline-based chemotherapy. Based on the BCIRG 001 trial, the submitted evidence shows that TAC is associated with superior disease-free and overall survival at 5 years compared with the anthracycline-based regimen FAC. The absolute risk reduction in patients treated with TAC compared with those treated with FAC was 7% for disease-free survival and 6% for overall survival. However, TAC was associated with significantly greater toxicity than FAC. There is also evidence that docetaxel, in an unlicensed sequential regimen FEC100-T, is associated with superior diseasefree and overall survival at 5 years compared with FEC100. An economic model was developed by the manufacturer based on the BCIRG 001 trial. This generated central estimates of the cost per life-year gained and cost per quality-adjusted lifeyear (QALY) gained of TAC compared with FAC of £7900 and £9800 respectively. The manufacturer’s submission predicts a cost-effectiveness of £15,000–£20,000 per QALY gained for TAC compared with E-CMF (epirubicin in sequential therapy with cyclophosphamide, methotrexate, and fluorouracil), and estimates the cost-effectiveness of FEC100-T to be £8200 per QALY compared with FEC100. Taking into account a number of issues identified by the ERG this may generate higher estimates of cost-effectiveness, but these are unlikely to exceed £35,000 per QALY gained. Importantly, FAC is not commonly used in clinical practice in the UK and, therefore, the submitted evidence does not indicate whether TAC is superior to the anthracycline-based regimens that are in common use (FEC or E-CMF). The indirect comparisons presented suggest that the economic case for TAC in comparison to current UK practice may not be proven. The manufacturer’s submission failed to record evidence of three serious adverse events in patients receiving docetaxel with doxorubicin or to mention the concern of the European Medicines Agency regarding TAC’s long-term adverse events. The guidance issued by NICE in June 2006 as a result of the STA states that docetaxel, when given concurrently with doxorubicin and cyclophosphamide (the TAC regimen), is recommended as an option for the adjuvant treatment of women with early nodepositive breast cancer.
Infliximab for the treatment of adults with psoriasis
Authors: Loveman E , Turner D , Hartwell D , Cooper K , Clegg A
Published: February 2021

This paper presents a summary of the evidence review group (ERG) report into the clinical and cost-effectiveness of infliximab for the treatment of moderate to severe plaque psoriasis, in accordance with the licensed indication, based on the evidence submission from Schering-Plough to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal (STA) process. The outcomes stated in the manufacturer’s definition of the decision problem were severity [Psoriasis Area and Severity Index (PASI) score], remission rates, relapse rates and health-related quality of life. The main evidence in the submission comes from four randomised controlled trials (RCT) comparing infliximab with placebo and eight RCTs comparing either etanercept or efalizumab with placebo. At week 10, patients on infliximab had a significantly higher likelihood of attaining a reduction in PASI score than placebo patients. There were also statistically significant differences between infliximab and placebo in the secondary outcomes. In the comparator trials both the efalizumab and etanercept arms included a significantly higher proportion of patients who achieved a reduction in PASI score at week 12 than the placebo arms. No head-to-head studies were identified directly comparing infliximab with etanercept or efalizumab. The manufacturer carried out an indirect comparison, but the ERG had reservations about the comparison because of the lack of information presented and areas of uncertainty in relation to the included data. The economic model presented by the manufacturer was appropriate for the disease area and given the available data. The cost-effectiveness analysis estimates the mean length of time that an individual would respond to infliximab compared with continuous etanercept and the utility gains associated with this response. The base-case incremental cost-effectiveness ratio (ICER) for infliximab compared with continuous etanercept for patients with severe psoriasis was £26,095 per quality-adjusted life-year. A one-way sensitivity analysis, a scenario analysis and a probabilistic sensitivity analysis were undertaken by the ERG. The ICER is highly sensitive to assumptions about the costs and frequency of inpatient stays for non-responders of infliximab. The guidance issued by NICE in August 2007 as a result of the STA states that infliximab within its licensed indication is recommended for the treatment of adults with very severe plaque psoriasis, or with psoriasis that has failed to respond to standard systematic therapies. Infliximab treatment should be continued beyond 10 weeks in people whose psoriasis has shown an adequate response to treatment within 10 weeks. In addition, when using the Dermatology Life Quality Index (DLQI), care should be taken to take into account the patient’s disabilities, to ensure DLQI continues to be an accurate measure.
Sunitinib for the treatment of gastrointestinal stromal tumours: a critique of the submission from Pfizer
Authors: Bond M , Hoyle M , Moxham T , Napier M , Anderson R
Published: February 2021

The submission’s evidence for the clinical effectiveness and cost-effectiveness of sunitinib for the treatment of gastrointestinal stromal tumours (GISTs) is based on a randomised controlled trial (RCT) comparing sunitinib with placebo for people with unresectable and/or metastatic GIST after failure of imatinib and with Eastern Cooperative Oncology Group (ECOG) progression status 0–1, and an ongoing, non-comparative cohort study of a similar population but with ECOG progression status 0–4. The searches are appropriate and include all relevant studies and the RCT is of high quality. In the RCT sunitinib arm overall survival was 73 median weeks [95% confidence interval (CI) 61 to 83] versus 75 median weeks (95% CI 68 to 84) for the cohort study. However, time to tumour progression in the cohort study was different from that in the RCT sunitinib arm [41 (95% CI 36 to 47) versus 29 (95% CI 22 to 41) median weeks respectively]. Median progression-free survival with sunitinib was 24.6 weeks (95% CI 12.1 to 28.4) versus 6.4 weeks (95% CI 4.4 to 10.0) on placebo (hazard ratio 0.333, 95% CI 0.238 to 0.467, p < 0.001). The manufacturer used a three-state Markov model to model the cost-effectiveness of sunitinib compared with best supportive care for GIST patients; the modelling approach and sources and justification of estimates are reasonable. The base-case incremental cost-effectiveness ratio (ICER) was £27,365 per quality-adjusted life-year (QALY) with the first cycle of sunitinib treatment not costed; when we included the cost of the first treatment cycle we estimated a base-case ICER of £32,636 per QALY. Pfizer’s sensitivity analysis produced a range of ICERs from £15,536 per QALY to £59,002 per QALY. Weaknesses of the manufacturer’s submission include that the evidence is based on only one published RCT; that 84% of the RCT control population crossed over to the intervention group, giving rise to the use of unusual rank preserved structural failure time (RPSFT) analysis to correct for possible bias; and that a number of errors and omissions were made in the probabilistic sensitivity analysis, meaning that it is not possible to come to firm conclusions about the cost-effectiveness of sunitinib for GIST in this patient population. In conclusion, during the blinded phase of the RCT, overall survival was significantly longer in the sunitinib arm than in the placebo arm (hazard ratio 0.491, 95% CI 0.290 to 0.831, p <0.007). However, intention-to-treat analysis of the entire study showed no statistically significant difference in overall survival for those who received sunitinib (73 weeks) versus those who received placebo (65 weeks) (hazard ratio 0.876, 95% CI 0.679 to 1.129, p = 0.306).
Trabectedin for the treatment of advanced metastatic soft tissue sarcoma
Authors: Simpson EL , Rafia R , Stevenson MD , Papaioannou D
Published: February 2021

This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of trabectedin for the treatment of advanced metastatic soft tissue sarcoma, in accordance with the licensed indication, based on the evidence submission from the manufacturer to NICE as part of the single technology appraisal (STA) process. The outcomes stated in the manufacturer’s definition of the decision problem were overall survival (OS), progression-free survival (PFS), response rates, adverse effects of treatment, health-related quality of life, and cost per quality-adjusted life-year (QALY) gained. The clinical evidence was derived from one randomised controlled trial (RCT), in which the licensed dose of trabectedin was compared with a different dose of trabectedin, and three phase II studies. In the RCT, the median OS was 13.9 months for the licensed dose of trabectedin, which was not significantly different from that for the comparator dose of trabectedin, which was 11.8 months. From the phase II uncontrolled trials, median OS was reported as 9.2 or 12.8 months. The RCT reported significantly superior PFS for the licensed dose of trabectedin (median 3.3 months) over the comparator trabectedin dose (median 2.3 months). One phase II uncontrolled trial reported median PFS as 1.9 months in the licensed dose of trabectedin. The RCT reported PFS rates at 6 months were 35.5% for the licensed dose of trabectedin, and 27.5% for the comparator dose of trabectedin. From the phase II uncontrolled trials, PFS rates at 6 months were 24.4% or 29%. For the RCT, deaths attributed to trabectedin occurred in 3.1% of the licensed dose, and 2.3% of the comparator group. The most common severe adverse events were neutropenia, although with a low rate of febrile neutropenia, thrombocytopenia, and aspartate aminotransferase and alanine aminotransferase elevation, although these were reported to be non-cumulative and reversible. Following dialogue iterations with the ERG team, the manufacturer revised the model twice. However, despite revisions, errors/inconsistencies were found in the latest version of the model and were corrected by the ERG (only for the base case). In the latest manufacturer’s submission, the cost per QALY gained of trabectedin compared with best supportive care (BSC) was estimated to be £56,985 for the base case using effectiveness from the STS (Soft Tissue Sarcomas)-201 trial for trabectedin and a pool analysis of the European Organisation for Research and Treatment of Cancer data set for BSC. This analysis was constrained to patients with L–sarcomas only. When the joint uncertainty between parameters was considered, the cost-effectiveness acceptability curve showed that trabectedin has a very low probability of being cost-effective at a threshold of £30,000 per QALY gained compared with BSC for any scenario. The guidance has yet to be issued by NICE.
NATOV CENTER ODLIČNOSTI ZA GORSKO BOJEVANJE – IZZIVI, PRILOŽNOSTI IN INTERESI
Authors: ZUPANČIČ MARJAN , POKLUKAR KARMEN , KOLBL RAFAEL
Published: February 2021

Na ozemlju Republike Slovenije je marca 2015 kot nova mednarodna organizacija začel delovati Natov center odličnosti za gorsko bojevanje. Institucija z ustanovitvijo, akreditacijo in aktivacijo prinaša vrsto izzivov in priložnosti, ki jih lahko zainteresirane strani razvijajo in izkoriščajo. Interesi udeležencev so različni, zato Natov center odličnosti za gorsko bojevanje že v začetni fazi poskuša opredeljevati priložnosti, ki temeljijo na potrebah sodelujočih držav. Za doseganje želene učinkovitosti in kakovosti bo treba upoštevati številne dejavnike, ki opredeljujejo novo institucijo. Obsežen seznam možnosti za razvoj gorskega bojevanja zahteva oblikovanje vsebinskega težišča, na katerega se bo center osredotočal v prihodnje.

NATO Mountain Warfare Centre of Excellence began its operation in March 2015 as a new international organisation in the territory of the Republic of Slovenia. Its establishment, accreditation and finally its activation, bring a number of new challenges and opportunities, which could be developed and exploited by stakeholders and other interested parties. Interests of participants vary; therefore NATO Mountain Warfare Centre of Excellence tries to focus in the very beginning on the opportunities based on the expressed needs and requests. In order to achieve the desired effectiveness and quality, a series of factors defining the new institution will have to be taken into account. A wide range of possible mountain warfare development options calls for the creation of a substantive centre of gravity, which will be the Centre’s focus in the future.
Z METODOLOGIJO UGOTAVLJANJA VODITELJSKEGA POTENCIALA KONČNO DO ODLIČNIH VOJAŠKIH VODITELJEV?
Authors: OKOVIČ DEJAN
Published: February 2021

Vojaško voditeljstvo je način vodenja vojaških organizacij. Neposredno vpliva na sposobnost organizacije za doseganje poslanstva in na organizacijsko klimo, s tem pa tudi na zadovoljstvo pripadnikov. V Slovenski vojski bodo po uvedbi Metodologije za ugotavljanje voditeljskega potenciala razpolagali z vsemi potrebnimi orodji uvajanja vojaškega voditeljstva. Članek pojasnjuje pomen vojaškega voditeljstva, načine usposabljanja vojaških voditeljev ter predstavlja Metodologijo za ugotavljanje voditeljskega potenciala in njeno dodano vrednost. Predstavljena je organizacijska in programska urejenost področja, predlagane so praktične rešitve za učinkovitejše delovanje sistema. Military leadership is the way of leading military organizations. It directly impacts the organization’s ability to fulfil its mission, as well as the organizational culture and the satisfaction of individuals. After adopting the Methodology of Determining the Leadership Potential, the Slovenian Armed Forces will have all the necessary tools to introduce military leadership. The article explains the importance of military leadership and possible ways of leadership training. Furthermore, it introduces the Methodology of Determining Leadership Potential and its added value, as well as the organisational and programme arrangement of this area. Finally, the author proposes some practical solutions to increase the effectiveness of the system.
TECHNICAL AND VOCATIONAL EDUCATION AND TRAINING SKILLS: AN ANTIDOTE FOR JOB CREATION AND SUSTAINABLE DEVELOPMENT OF NIGERIAN ECONOMY
Authors: Edokpolor James Edomwonyi , Owenvbiugie Robinson Osarumwense
Published: February 2021

The research is aimed at assessing the important role of TVET on job creation and sustainable development of Nigerian economy. Two research questions were answered using mean and standard deviation statistics, while two hypotheses were tested using t-test statistic. A survey method was employed for the research. A four-point scale questionnaire was employed as the instrument for collection of data. The population consists of 332 TVET lecturers in 3 universities and 4 colleges of education in Edo and Delta States. There was no need to adopt sampling technique, nor select any sample size, since the entire population is of a manageable size. The instrument was validated by two experts and its reliability coefficient value using Cronbach alpha method was 0.81. The research revealed that TVET can equip students with skills for job creation and sustainable development of Nigerian economy. It also revealed that there was no significant difference between the mean ratings of TVET lecturers in Edo and Delta States on the extent to which TVET can equip students with skills for job creation. It further revealed that there was no significant difference between the mean ratings of male and female TVET lecturers on the extent to which TVET can equip students with skills for sustainable development of Nigerian economy. Optimizing sufficient amount of financial resources, regular supplies of state-of-the-art facilities, sourcing for qualified manpower, and organization of advocacy programme, that would help in effective management delivery of TVET were further recommended.
Keywords: job creation, Nigerian economy, sustainable development, social skills, TVET skills.
Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis
Authors: Dobson Rachel , Du Peter Y. , Rásó-Barnett Lívia , Yao Wen-Qing , Chen Zi , Casa Calogero , EI-Daly Hesham , Farkas Lorant , Soilleux Elizabeth , Wright Penny , Grant John W. , Rodriguez-Justo Manuel , Follows George A. , Rashed Hala , Fabre Margarete , Baxter E. Joanna , Vassiliou George , Wotherspoon Andrew , Attygalle Ayoma D. , Liu Hongxiang , Du Ming-Qing
Published: February 2021

Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma with T follicular helper phenotype (PTCL-TFH) are a group of complex clinicopathological entities that originate from T follicular helper cells and share a similar mutation profile. Their diagnosis is often a challenge, particularly at an early stage, because of a lack of specific histological and immunophenotypic features, paucity of neoplastic T cells and prominent polymorphous infiltrate. We investigated whether the lymphoma-associated RHOA Gly17Val (c.50G>T) mutation, occurring in 60% of cases, is present in the early “reactive” lesions, and whether mutation analysis could help to advance the early diagnosis of lymphoma. The RHOA mutation was detected by quantitative polymerase chain reaction with a locked nucleic acid probe specific to the mutation, and a further peptide nucleic acid clamp oligonucleotide to suppress the amplification of the wild-type allele. The quantitative polymerase chain reaction assay was highly sensitive and specific, detecting RHOA Gly17Val at an allele frequency of 0.03%, but not other changes in Gly17, nor in 61 controls. Among the 37 cases of AITL and PTCL-TFH investigated, RHOA Gly17Val was detected in 62.2% (23/37) of which 19 had multiple biopsies including preceding biopsies in ten and follow-up biopsies in 11 cases. RHOA Gly17Val was present in each of these preceding or follow-up biopsies including 18 specimens that showed no evidence of lymphoma by combined histological, immunophenotypic and clonality analyses. The mutation was seen in biopsies 0-26.5 months (mean 7.87 months) prior to the lymphoma diagnosis. Our results show that RHOA Gly17Val mutation analysis is valuable in the early detection of AITL and PTCL-TFH.
The Work Area of the Sidomulyo Health Center UPTD Outpatient in Pekanbaru City
Authors: Dince Safrina  , Oktavia Dewi  , Nurlisis Nurlisis  , Mitra Mitra  , Ika Putri Damayanti
Published: February 2021

Anemia in pregnant women is a condition of mothers with hemoglobin (Hb) levels less than 11gr / dl which can cause the risk of bleeding, stunted fetal growth (CHD), prematurity, low birth weight (LBW), and stunting and even death in pregnant women. The aim of the study was to analyze the factors associated with the incidence of anemia in pregnant women in the working area of the Sidomulyo Health Center Outpatient Pekanbaru City. The research method used quantitative type with cross sectional design. The population of pregnant women in the 2nd and 3rd trimesters based on secondary data from medical records for January 2019 - March 2020 was 2036 people with a sample size of 325 people. The sampling technique used systematic random sampling using secondary data taken from medical records. Data analysis was performed univariate, bivariate and multivariate with multiple logistic regression. The results showed that 192 pregnant women with anemia (59.1%) were significantly associated with anemia in pregnant women in the work area of the UPTD Puskesmas Sidomulyo Outpatient Pekanbaru City nutritional status (POR = 40.647, parity (POR = 3.473), Maternal age (POR = 1,993). It was concluded that the dominant variable related to anemia in pregnant women in the work area of the UPTD Sidomulyo Puskesmas Outpatient Pekanbaru City was nutritional status (POR = 40,647). It is recommended to UPTD Puskesmas Sidomulyo Outpatient to increase the coverage of program implementation. ANC 10 T service standards, when the Covid epidemic is currently increasing online promotion and prevention by utilizing available technology. It was concluded that the dominant variable related to anemia in pregnant women in the work area of the UPTD Puskesmas Sidomulyo Outpatient Pekanbaru City was nutritional status (POR = 40.647). It is recommended that the UPTD Puskesmas Sidomulyo Outpatient to increase the scope of the implementation of the 10 T ANC service standard program. When the Covid epidemic is currently increasing promotion and prevention online by utilizing available technology. It was concluded that the dominant variable related to anemia in pregnant women in the work area of the UPTD Puskesmas Sidomulyo Outpatient Pekanbaru City was nutritional status (POR = 40.647). It is recommended that the UPTD Puskesmas Sidomulyo Outpatient to increase the scope of the implementation of the 10 T ANC service standard program. When the current Covid epidemic increases promotion and prevention online by utilizing available technology.
Server Design Using Raspberry pi for E-Waiter Application in CV. Dcust System Banda Aceh
Authors: Husaini Husaini , Salat Junaidi , Mahfud Danil
Published: February 2021

Raspberry pi minicomputer is a practical tool in terms of dimensions and has complex functions for various functional needs that will be used by humans as a microcontroller, server to digital images. Technological developments in the field of Internet of Things (IoT) and servers have brought enormous changes for many people. one of them is in the field of cafe service, with the e-waiter application it can provide many benefits for cashier services and cafe management, therefore the authors build a web server for e-waiter applications into IoT devices in the form of a Raspberry Pi.The purpose of this research is to build a useful application to facilitate cafe owners in running their business and controlling sales management.
Lasers aplicados à frenectomia em pacientes pediátricos com anquiloglossia
Authors: Nunes José Edson Pavini , Silva Ayrthon Lucena da , Nunes Guilherme Pavini , Fagundes Caroline Ferreira , Souza Matheus Rodrigues de , Navarro Ricardo Scarparo
Published: February 2021

A anquiloglossia, ou língua presa, é uma condição pela qual o frênulo lingual se fixa próximo à ponta da língua e pode ser curto, tenso e grosso. A anquiloglossia foi citada como uma causa de amamentação inadequada e dor nos mamilos maternos. A frenotomia ou frenectomia pode corrigir a restrição ao movimento da língua e permitir uma amamentação mais eficaz com menos dor no mamilo materno. Tradicionalmente, a intervenção cirúrgica é realizada com bisturi, porém nos últimos anos houve um importante advento do uso do laser neste procedimento. Objetivo: realizar uma revisão sistemática sobre o uso de lasers como terapia para anquiloglossia. Métodos: revisão sistemática de estudos clínicos randomizados com pontuação ≥ 6 na escala PEDro (Physiotherapy Evidence Database) publicados nas bases de dados PubMed, Cochrane e SciELO. Foram selecionados estudos que avaliaram o uso do laser no tratamento de crianças com anquiloglossia. Resultados: No total, foram analisados 7 estudos utilizando o laser Diodo ou CO2 como uma das técnicas de frenectomia. Em 401 pacientes submetidos à frenectomia lingual, o benefício entre a realização da técnica a laser sobre a técnica de bisturi tradicional está claramente descrito. Conclusão: A cirurgia de frenectomia lingual com lasers proporciona um tratamento mais eficiente e confortável para o paciente infantil em comparação aos métodos tradicionais de bisturi/lâmina. Porém, ainda não há consenso ou evidência para indicar o comprimento de onda laser a ser utilizado.
Evolução e qualidade de vida em pós-operatório de cirurgia vascular
Authors: Mendes João Pedro Sousa , Araújo Adrielly Cristhine Gonçalves , Lima Cláudio Vinícius Barroso Queirós de , Cavalcante Igor dos Santos , Barbosa João Victor Carvalho , Rodrigues Priscylla Frazão , Fonseca Neto Olívio Joaquim , Pereira Andressa Carvalho , Viana Brenda Larissa Andrade , Mendes Isabella Pires Gomes , Souza Juliano Luiz de , Krüger Yasser da Silveira , Magalhães Neto Elias de Carvalho , Mendes Érica de Araújo Silva
Published: February 2021

Este estudo tem como objetivo analisar e avaliar a qualidade de vida na recuperação de pacientes no período de pós-operatório em cirurgias vasculares. Métodos: trata-se de uma revisão de literatura integrativa, a qual se realizou uma pesquisa bibliográfica nas seguintes bases de dados, selecionadas através do metabuscador do Portal Periódico CAPES: Scientific Electronic Library Online (SciELO), Medical Literature Analysis and Retrievel System Online (Medline) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), utilizando os descritores “Cirurgia vascular”, “Pós-operatório” e “Qualidade de vida”, que foram pesquisados nos Descritores em Ciências da Saúde (DECs). Após a leitura analítica, apenas 14 artigos atenderam aos critérios de inclusão e foram utilizados para compor a amostra final deste estudo. Foram utilizados os artigos que estivessem enquadrados como estudos com seres humanos e publicados entre 2010 e 2020. Resultados: a técnica cirúrgica tem grande influência na evolução do quadro clínico do paciente. Novas técnicas surgem com o objetivo de ser menos invasivas e proporcionarem uma melhor recuperação. Porém, algumas patologias, por serem graves, ainda apresentam uma alta taxa de mortalidade e complicações. Conclusão: Pacientes acometidos por doenças vasculares necessitam de um cuidado especial no intuito de evitar complicações no pós-operatório e garantir uma boa qualidade de vida. Observou-se que além da gravidade da doença, a avaliação da realidade que o paciente está inserido tem importância considerável na qualidade de vida, uma vez que os fatores biopsicossociais impactam de forma significativa no processo de adoecimento.
Genetic variability of Colletotrichum sublineolum through ISSR markers
Authors: Guimarães Thallita Santos , Barelli Marco Antonio Aparecido , Corrêa Carla Lima , Silva Valvenarg Pereira da , Floriano Alex Junior Sandol , Sander Nilo Leal , Duarte Aline Vidor Melão , Zago Bruno Wagner , Ribeiro Jackson Lauro Borges , Tardin Flávio Dessaune , Silva Dagma Dionísia da
Published: February 2021

The occurrence of diseases is a limiting factor in the development of sorghum crop. Among the diseases that causes losses in sorghum production, anthracnose is the main and most severe, mainly by the genetic variability of the pathogen. In this context, the aim of this study was to evaluate the genetic variability of Colletotrichum sublineolum isolates. DNA were extracted from 56 monosporic isolates of C. sublineolum using a DNA extraction kit, and to perform the analysis of genetic diversity of the isolates were used ISSR primers. After amplification, it was determined the polymorphic information content (PIC), allelic frequency, UPGMA and Tocher clustering analyzes and, using software Structure, the genetic structure. According to the descriptive analysis of the genetic variability of C. Sublineolum isolates, primer AP1 presented the higher value of polymorphic information content (PIC). The higher allelic frequency was observed in loci 06, 09, 10, and 24, and the lowest in locus 02. As for the clustering method, it was observed a tendency of grouping C. sublineolum isolates according the geographic origin and, in addition to demonstrating the genetic variability between the C. sublineolum isolates, it was observed the occurrence of introgression among the isolates.
Vida útil de carne bovina moída comercializada no Município de Boa Vista – Roraima
Authors: Cipriano Lévison da Costa , Sousa Leiras Benjamin de , Siqueira Heloisa Pinto de Godoy , Lima Everton Ferreira , Messias Cassio Toledo , Marchi Patrícia Gelli Feres de , Medeiros Elizabeth Sampaio de , Hoppe Ingrid Bortolin Affonso Lux , Siqueira André Buzutti de
Published: February 2021

A carne bovina é consumida em todo o mundo, porém de acordo com as características próprias (físicas, química e biológica) podem sofrer processos acentuados de deterioração, assim como serem carreadoras de organismos deterioradores e ou patogênicos. A partir disso, o objetivo deste trabalho foi determinar a vida útil da carne moída comercializada em hipermercados e mercados do município de Boa Vista-RR, por meio de análises sensoriais, pH e indicadores de contaminação: microrganismos aeróbios mesófilos e aeróbios psicrotróficos. As análises foram realizadas no Laboratório de Produtos de Origem Animal da Universidade Federal de Roraima. Foi realizada a análise sensorial de acordo com características visualizadas no decorrer do armazenamento do produto, o pH foi determinado por meio do pHmetro e contagem de microrganismos. Dos resultados obtidos, a vida útil da carne moída em relação às análises sensoriais foi em torno de sete dias. O que diz a respeito da qualidade microbiológica da carne moída, segundo a legislação brasileira a carne estava apta para consumo até o décimo dia de armazenamento, com contagens de bactérias mesófilas e psicrotróficas, respectivamente, em torno de 4,3 x 10⁵ UFC/25g e 4,4 x 10⁵ UFC/25g. Quanto aos valores de pH da carne apresentavam-se em conformidade com legislação brasileira vigente, apenas no primeiro dia de armazenamento. No entanto, são necessários mais estudos na região a respeito da qualidade da carne moída, que quando comprometida, pode representar perigos à Saúde Pública.
Efeito da inoculação de sementes com Azospirillum brasilense sobre o fracionamento nitrogenado e glicídico em silagens de sorgo
Authors: Schumacher Larissa Luísa , Viégas Julio , Tonin Tiago João , Pereira Stela Näetzold , Skonieski Fernando Reimann , Cardoso Gilmar dos Santos , Hora Ana Luiza Van Caeneghem da , Teixeira Janaína Vargas , Temp Larissa Bordin , Nemoto Beatriz dos Santos
Published: February 2021

A inoculação com Azospirillum brasilense apresenta potencial de uso na cultura do sorgo (Sorghum bicolor [L.] Moench) pela possibilidade de alterar a fisiologia e morfologia das plantas. Neste sentido, o presente estudo tem por objetivo avaliar a influência da inoculação via semente com a bactéria promotora de crescimento da estirpe Azospirillum brasilense sobre a composição morfológica, parâmetros fermentativos, perdas nutricionais, frações nitrogenadas e de carboidratos em silagem de sorgo do híbrido AG 2005. O delineamento experimental foi o inteiramente casualizado, constituindo-se de dois tratamentos (com e sem inoculação), com quatro repetições de silos. O fracionamento nitrogenado, foi determinado conforme descrito por Licitra et al. (1996) e para mensurar o fracionamento dos carboidratos, foi avaliado de acordo com a metodologia proposta por Lanzas et al. (2007). As plantas inoculadas apresentaram menor porcentagem de colmo, mas houve maior participação de panícula mais grãos. O híbrido inoculado produziu silagem com menor teor de nitrogênio insolúvel em detergente ácido (NIDA) e nitrogênio insolúvel em detergente neutro (NIDN). Com relação ao fracionamento de carboidratos, as silagens de sorgo com inoculação diferiram significativamente em CHO (carboidratos totais) e CC (fibra indigestível) em relação ao controle. Sobre o fracionamento proteico, a fração   indigestível (PC), a inoculação apresentou redução de 0,29 unidade percentuais quando comparado ao controle. Desta forma, a inoculação de sementes com A. brasilense pode ser uma alternativa viável, pois apresenta potencial de reduzir a fração de proteína e glicídios insolúvel e indigestível no trato gastrointestinal em silagens de sorgo.