bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Product Quality and Service Quality on Customer Satisfaction
Authors: Lbn. Raja* Edward A. , Maharani Maharani , Raja John G. Lbn.
Published: May 2023

In producing a product, the quality of the product is something that must be done by the company so that consumers will feel satisfied with the product that will be used by the customer. product quality will have an influence on customer satisfaction so that the use of the product will occur at a later time because there is satisfaction. In addition to product quality that will be felt by customers, it is also necessary to provide good service to customers so that customers feel well served by the company or service provider. respondents who serve as the population and research samples are customers Cafe Hans as many as 72 people. The results of the study explain that the effect of product quality on customer satisfaction is T count 91.9% where product quality really has a major influence on customer satisfaction at Hans Café, the effect of service quality on customer satisfaction is T count 2.7% where product quality only gives a small contribution to customer satisfaction and the influence of product quality and service quality on customer satisfaction is F count of 50% where together product quality and service quality have an influence on customer satisfaction.
Effect of Current Ratio and Return on Asset on Company Value (Case Study on Food and Beverage Subsector Manufacturing Companies Listed on the Indonesia Stock Exchange in 2018-2020)
Authors: Silaen* Karina , Maduwu Lilis Dariyanti , Zebua Adiwima
Published: May 2023

This research was conducted to determine the effect of current ratio and return on assets on company value. This research uses quantitative methods. In this study, the population is a food and beverage sub-sector manufacturing company listed on the Indonesia Stock Exchange in 2018-2020. Sample sampling technique using purposive sampling technique using several criteria. The data analysis technique uses classical assumption test, multiple linear regression analysis test, T test, F test and coefficient of determination (R2) test using SPSS application version 16. From the results of the study shows that the results of the T test, the current ratio variable has an effect but is not significant on the value of the company and the results of the T test, the variable Return On Asset on the value of the company has an effect and is significant to the value of the company. And from the results of the study shows that the results of the F test together with current ratio and return on assets have an effect and are significant on the value of the company.
The Effect of Capital Intensity, Liquidity, and Firm Size on Tax Aggressiveness In Property and Real Estate Sub Sector Companies Listed In The Indonesian Stock Exchange 2017-2021 Period
Authors: Juwita* Ratih , Antoni Antoni , Usman Susanti
Published: May 2023

This study aims to analyze the effect of capital intensity, liquidity, and company size on tax aggressiveness.The population in this study are property and real estate sub-sector manufacturing companies listed on the Indonesia Stock Exchange in the 2017-2021 period. The sampling method was purposive sampling and obtained a sample of 15 companies. The analytical technique used in this research is multiple linear regression analysis. The data was processed using SPSS. The results of this study indicate that the size of the company has an effect on tax aggressiveness, while capital intensity and liquidity have no effect on tax aggressiveness. Then capital intensity, liquidity and firm size simultaneously affect tax aggressiveness.
The Role and Efforts of the School Committee in Improving the Quality of Education at SMA Negeri 5 Banda Aceh
Authors: Ismail Ismail , Shella Nathasya Putri Norizan , Hadiyani Rahmilia , Mustofa Achmad , Anggraini Irma , Ruaida Ruaida
Published: May 2023

This research aims to determine (1) the role and efforts of the school committee in improving the quality of education at SMA Negeri 5 Banda Aceh and (2) the obstacles faced by the school committee in improving the quality of education at SMA Negeri 5 Banda Aceh. This article uses qualitative approach with qualitative descriptive research methods. The research subjects consisted of school principals and school committees. This research data collection technique is to use interview techniques, and documentation. The results of this study indicate that the school committee has carried out its role well, namely as an advisory agency, a supporter (supporting agency), a controller (controlling agency), and as a liaison agency (mediator agency). There are several obstacles faced by the school committee, namely in the implementation of learning carried out in schools is still limited to learning in the classroom, which means that learning is carried out limited to the delivery of material and the work plan has not been formed by the committee at SMA Negeri 5 Banda Aceh.
The Provision of Lend Based on Collateral in the Form of Inherited Objects on Behalf of the Heirs in Relation to the Principle of Legal Certainty
Authors: Alensia* Melysa Putri , Lunandi Yenny Yuniawaty
Published: May 2023

Financial limitations to make ends meet, allow everyone to borrow some money from individuals and banking institutions. In granting credit to debtors, the bank requires the debtor to provide collateral. In practice, there is land and/or buildings which are objects of inheritance on behalf of the testator which are used as collateral when applying for credit to the bank. This study aims to understand and examine legal certainty for banks as creditors if the debtor uses the object of inheritance as collateral in applying for credit. In this study the authors used a legal research method that used a normative juridical research type, namely research that was intended to conduct a study of the application of rules or norms in positive law. The data source used by the author in this study is secondary data obtained from library research. The results of the research show that collateral is an important requirement in granting credit. Collateral is the bank's belief in the ability and ability of the debtor to pay off his debt obligations according to the agreement,  so that the bank should have strict criteria for receiving guarantees from the debtor. behind the first name on behalf of the heirs in order to provide legal certainty for the bank as a creditor.
Folklore, Analysis and Utilization of the Golden Cave and Silver Cave
Authors: Syafitri Novia , Maulana Muhammad Hanafi , Arraihan Haddad Wifaq , Putri Nezeliana , Prayitno Nugroho Hadi , Harahap Apriani
Published: May 2023

The Gold Cave and Silver Cave are tourist attractions located in Durian IV Mbelang Village, STM Hulu District, Deli Serdang Regency, North Sumatra. Based on the data obtained, the gold cave and silver cave save a lot of historical history. Even these caves have their own uniqueness, namely there are silver and gold grains at several points on the cave walls. The historical story and the uniqueness of the cave became the basis for conducting a study to uncover the scientific truth of the gold and silver cave in history and laboratory testing of the authenticity of the gold and silver. This study uses qualitative methods to describe and describe existing phenomena, both natural and human engineered. This method consists of several stages of research interviews and observations using data analysis model Miles and Huberma techniques and observations of recordings and research notes so that every information can be recorded properly. The results showed several legend stories and cave naming if in a hermeneutic perspective the legend stories and the names of the caves were made for the preservation of the cave and increasing the tourism of the cave. Laboratory tests proved the presence of particles resembling gold (Titanium Nitride compounds, Ti2N) and silveccr (Nickel Iron Oxid compounds, NiFe2O4).
The Existence of The Malay House ‘Limas Potong’ In the Midst of Modernization Currents in the City of Batam 1970-2022
Authors: Monikasari* Monikasari , Fitriyanti Fitriyanti
Published: May 2023

The purpose of this study was to determine the impact of the modernization of the city of Batam on the existence of the Malay House Limas Potong. The method used in this research is historical research. The steps in this research are heuristics, source criticism, interpretation, and historiography. The results of the study show that the very first simple industrial concept in Batam, which began in 1898, was the Pertuan Muda of Riau, Raja Muhammad Yusuf-Ahmadi on behalf of the Riau Lingga Kingdom, who granted part of Batam Island land to King Abdullah, Raja Ali Kelana and Raja Muhammad Thahir. In 1978 B.J Habibie changed the course of Batam's development. Batam was transformed into the direction of industrial, service, trade,transhipment and tourism. The Malay House Limas Potong once dominated the architectural forms of houses in Batam City. Currently, the construction of a Malay house with the traditional architecture of the Malay House Limas Potong is no longer a prima donna. Construction efficiency, land availability, difficulty in obtaining raw materials, and up to the development of today's architectural models have changed a lot. The only Malay House Limas Potong currently in Batam City is in Kampung Melayu, Nongsa District.
Policy Implementation of Law No. 35 of 2014 Regarding Child Protection in Cibeber District, Lebak Regency
Authors: Nurlia* Elly , Nursyiam Nurul , Ariyan Said
Published: May 2023

Child protection is all the forms that are implemented that every child can get the rights and responsibilities to grow and develop naturally, both physically, mentally, and socially. The purpose of this research is to find out the implementation of Law No. 35 of 2014 on Child Protection Policy in Cibeber District, Lebak Regency. The research used descriptive qualitative methods and the basis for the use of research methods aims to collect and analyze a certain process related to the research focus. The data obtained are presented descriptively and analyzed using descriptive analytic techniques of the case study type. The theory used in this research is the Implementation Theory of Donald Van Metter and Carl Van Horn in Widodo (2008). The results of the study show that the Cibeber District Government has socialized child protection regulations quite well, this is evidenced by the role of the Cibeber District Government in collaboration with related parties such as the Health Party, Law Enforcement Officials, Village Government Parties, Social Assistance Parties (PATBM), to socialize and implement programs related to child protection, especially in Law No.35 of 2014. The obstacles found are the lack of public understanding of child protection regulations, as well as socio-economic conditions that result in gaps in the occurrence of violence against children, besides that the form of programs and socialization carried out by the government is not carried out in stages.
The Effect of Non-Performing Loans (NPL) to the Bank Profitability During the Covid-19 Pandemic (Case Study of Buku III Bank in Indonesia)
Authors: Rusli* Moch. , Fitriana Aning
Published: May 2023

Bank is a financial institution that functions as a liaison between parties who have excess funds and those who need funds. In creating bank health, it is measured by profitability indicators to see the ability to increase profits, measure effectiveness and efficiency in management.  Its profitability can be seen from the value of ROA (Return On Assets) and ROE (Return On Equity).  The banking industry has problems in bad debtors which can be seen from the value of NPL (Non-Performing Loan) and this is exacerbated by special conditions that have occurred in recent years, namely the Covid-19 pandemic. So it is necessary to see how the effect of non-performing loans on bank profitability during the Covid-19 pandemic and this study conducted a case study on Buku III banks in Indonesia represented by 7 banks that reported financial data from 2019-2021, namely Bank HSBC Indonesia, Bank Tabungan Negara, Bank DBS Indonesia, Bank Permata, Bank Mega, Bank DKI, and Maybank Indonesia. The results show that the results of the analysis using SPSS version 25, partially non-performing loans represented with NPLs have no effect on the profitability of banks represented with ROA and ROE. Meanwhile, the same condition occurs in the results of the analysis test simultaneously or together with non-performing credit variables, namely NPLs, do not affect bank profitability, namely ROA and ROE.
The Annulment of Homologation in the Case of PKPU Application of Intidana Savings and Loan Cooperative in Review of Law Number 37 of 2004
Authors: A.A.P* Karina Widyadhari , Gultom Elisatris , Afriana Anita
Published: May 2023

The purpose of this research is to find out the annulment of homologation in the case of a PKPU application for KSP Intidana in terms of Law No. 37 of 2004. This research method is normative juridical which is guided by primary legal materials and secondary legal materials contained in a legislation. The results of the research show that first, the action of not accepting the annulment of homologation on the basis that the application submitted was premature is not in accordance with the provisions of the KPKPU Law because the concept of negligence as a reason for homologation annulment in the KPKPU Law is interpreted as an action where the debtor really does not fulfill the clauses agreed upon in the composition agreement, not waiting until the payment deadline expires. Secondly, the judge's action in not accepting the homologation annulment request submitted by KSP Intidana's creditors was inappropriate because it did not fulfil one of the principles of the decision in which the judge's decision must contain a clear basis.
Conscientiousness and Cognitive Abilities: a Meta-Analysis
Authors: Corbeanu Andreea
Published: May 2023

This paper analyzes the current state of knowledge regarding the relationship between Conscientiousness and cognitive ability. The association between the two variables, the correlation between the sub-factors of Conscientiousness and cognitive ability and the impact of the sample type on the relationship were explored. Following a systematic literature review, 81 unique studies were identified. In terms of inclusion criteria, studies had to (1) report any link between Conscientiousness and cognitive ability, (2) conceptualize Conscientiousness through the Big Five model, and (3) report a measure of cognitive ability (regardless of conceptualization). Several random-effects meta-analyses were conducted, obtaining meta-analytical correlations of .02, -.06 and -.06 between Conscientiousness (global) and cognitive abilities (global), crystallized intelligence and fluid intelligence, respectively. Moreover, for the correlations between the facets of Conscientiousness and cognitive abilities, 6 random-effect models were carried out, however the evidence was statistically significant only in the case of order and achievement striving scales. Finally, the sample type was considered as a potential moderator of the relationship between conscientiousness and cognitive ability, but it was not supported by the available data. These findings were discussed within the context of the relevant literature and several limitations and directions for future research were also taken into consideration.
A childhood dream that can be a memory: Magical Realism and Memory in the "Ocean at the End of the Lane"
Authors: Boulberhane Mouna , Aouati Somia , Saad Haider Luaibi , Ahmad Mahmood Mahmood , Hezla Mohammed
Published: May 2023

The novel "The Ocean at the end of the Lane" sheds light on the children's view of the world and the unique perception of reality, which is completely different from the perception of adults. The object of the study is the manifestations of memory impairment in the novel. The subject is the analysis of changes in memory with age, as well as its role in overcoming stress caused by trauma. The purpose of the article is to understand, in the light of personality psychology and memory research, how and why the memories of the child protagonist change and merge with the imagination as the narrative changes. This helps to identify oppositions of imagination and reality in the novel, which echoes the perception of the world by the main character-a child in parallel with the perception of the world by adults. The novelty of the research lies in the fact that psychological research is used in the article in order to show how magical realism reflects the problem of memory changes in the novel "Ocean at the End of the Lane", and, therefore, provides a basis for further opportunities to study children's magical perception, realistic memory in postmodern novels. The results of the study demonstrate to what extent the style of magical realism expresses the transformation of mental abilities and perception of reality during the transition from childhood to adulthood in the novel. In this sense, "The Ocean at the end of the Lane" is an image of the world seen both from the point of view of adult life and from the point of view of childhood.
Motivation factors in learning Azerbaijani and Turkish languages in Moscow
Authors: Hasanov Mammadali Magsad Ogly , Kambak Burak
Published: May 2023

Learning foreign languages is an important component of personal and professional development. There are a large number of national communities in Moscow, including Azerbaijani and Turkish, and more and more people are paying attention to learning the languages of these countries. In this article, we will study the motivation for studying Azerbaijani and Turkish in Moscow. Let's look at how learning these languages can help when communicating with native speakers, traveling, in professional activities and how this can help expand cultural horizons. We will also consider the most popular motives for learning these languages among students in Moscow. The object of this article is the motivation of students and students living in Moscow when studying Azerbaijani and Turkish languages. The subject of the article is an analysis of the motivation factors that inspire people to study Azerbaijani and Turkish in Moscow, such as cultural interest, employment opportunities, study, communication and other factors that can be identified in the research process. The article will also describe the different motivations of each language learner, their personal experiences and opinions about it, as well as general preferences in language learning.
The specifics of lexicographic representation of phraseological units in the "Russian-English Phraseological Dictionary" edited by S. Lubenskaya
Authors: Ren Jialu
Published: May 2023

This article is devoted to the study of the specifics of the lexicographic representation of the dictionary "Russian-English phraseological Dictionary" edited by S. Lubenskaya. Its comparative analysis with similar Russian-English phraseological dictionaries is carried out in the aspects of 1) the volume of the dictionary and 2) the lexicographic description of the phraseological units included in their dictionary entries. Russian phraseological units are considered, their English equivalents are identified, with an emphasis on the comparative analysis of the subject nouns of Russian phraseological units and their analogues in English equivalents. Special attention is paid to the structure of the dictionary article and the lexicographic representation of phraseological units in the dictionary of S. Lubenskaya, the parameters of Russian phraseological units are considered, their English equivalents are identified with an emphasis on the comparative analysis of the subject nouns of Russian phraseological units and their analogues in English equivalents. The purpose of the study is to compare the dictionary of S. Lubenskaya with other Russian-English phraseological dictionaries and to identify the specifics of the lexicographic description of phraseological units in the dictionary of S. Lubenskaya. The novelty of the research lies in the fact that in the article the author draws attention to the most complete and innovative, but little-studied Russian-English phraseological dictionary edited by S. Lubenskaya, published in 2013. The article fully demonstrates the advantages of S. Lubenskaya's dictionary over other bilingual phraseological dictionaries not only in terms of the range of coverage of materials, that is, the volume of the dictionary, but also in the completeness of the structure of the dictionary entry and a high degree of accuracy and detail of the presentation of the material. The article also notes the importance of S. Lubenskaya's dictionary for further and comprehensive research of Russian and English phraseological lexicography.
The concept of «culture» in the scientific biographies of the repressed scientist G. V. Ksenofontov during the Soviet nation-building period
Authors: Romanova Ekaterina Nazarovna , Pokatilova Nadezhda Volodarovna
Published: May 2023

In the study the personal history of the repressed intelligentsia of Yakutia, the name of the outstanding scientist and socio-political figure Gavriil Vasilyevich Ksenofontov (1888-1938) occupies a special place not only because of the tragedy of his personal fate, but also the actualization and significance at the present stage of his most conceptual ideas, which, like their author, have their own scientific destiny. For the first time, research of this type became possible thanks, on the one hand, to the invaluable layer of archival sources identified in the handwritten heritage of G. V. Ksenofontov, on the other hand, to the methodology of a comprehensive study of the biographical narrative in the intellectual tradition of the first Yakut humanities scholars within the framework of modern approaches to intellectual history. For the first time in the unpublished manuscript legacy of G. V. Ksenofontov, a special circle of ideas is highlighted, the most indicative in the aspect of the formation of his integral intellectual program. In his scientific notes of 1934-1937, G. V. Ksenofontov increasingly refers to the multidimensional concept of «culture», perceived as a whole as a complex mechanism of a complex producing principle associated with ethnic identity and national identity. In this regard, in the statements and research of the scientist of recent years, there is a steady interest in methodological research and the conceptual basis of related humanities disciplines. We will focus on their review and justification in the broad context of G. V. Ksenofontov's ideas about «culture», the reasons for their appearance in his scientific tools in this paper, which determined the subject and purpose of the study.
Makna Warna Tata Rias Wajah Pemain Kabuki pada Video Shibaraku
Authors: Ni Nyoman Sariyanti  , Meidariani Ni Wayan , Nurita I Wayan
Published: May 2023

Tulisan ini bertujuan untuk mengetahui makna warna tata rias wajah seni pertunjukan kabuki pada karakter antagonis, protagonis dan karakter Putri pada video Shibaraku. Analisis makna menggunakan teori semiotika Peirce melalui klasifikasi jenis tanda yang dilihat dari objeknya yaitu ikon berupa gambar tokoh kabuki, indeks berupa warna dan jenis riasan yang digunakan tokoh kabuki dan simbol berupa hubungan warna dengan karakter tokoh kabuki. Klasifikasi tanda tersebut telah digunakan untuk memaknai warna dalam tata rias wajah kabuki. Sumber data yang digunakan pada tulisan ini merupakan sumber data primer berbentuk video pertunjukan kabuki berjudul Shibaraku yang diunduh dari YouTube. Metode yang digunakan pada tulisan ini ialah metode kualitatif. Berdasarkan hasil analisis data, makna dan nama riasan tokoh dapat diketahui, tata rias wajah karakter protagonis yaitu riasan kumadori sujiguma dengan warna merah yang memiliki makna kebaikan dan keadilan. Sebaliknya, tata rias wajah karakter antagonis yaitu riasan kumadori kugeare dengan warna biru yang memiliki makna dingin atau kejam. Lalu, tata rias karakter Putri yaitu riasan standar dengan warna dasar putih yang memiliki makna kemurnian karakter, dan merah tipis pada bagian mata yang memiliki makna feminim dan keceriaan.

Kata kunci: kabuki; makna; tata rias; warna.
The Importance of Medication Adherence in the Treatment of Actinic Keratosis: An Expert Consensus Panel
Authors: Zakria Danny , Armstrong April , Berman Brian , Del Rosso James , Lebwohl Mark , Schlesinger Todd , Rigel Darrell
Published: May 2023

Background: Actinic keratosis (AK) is one of the most common dermatologic diagnoses. While there are several treatment options, many topical therapies have poor adherence due to duration of treatment and local skin reactions (LSRs).

Objective: To review the available literature on the most commonly used patient-administered field-directed therapies for AK and create consensus statements on the role of medication adherence in improving AK outcomes.

Methods: A literature search of PubMed was completed for English-language original research articles reporting efficacy, safety, and tolerability data for 5-FU, diclofenac gel, imiquimod cream, and tirbanibulin. Once the articles were selected, they were distributed to a panel consisting of seven dermatologists with extensive expertise in managing AKs. Each panelist reviewed the articles and assigned them a level of evidence based on Strength of Recommendation Taxonomy (SORT) criteria. The panelists then met to review and discuss the studies and created consensus statements on the management of AKs and the importance of medication compliance. A modified Delphi process was used to approve the adoption of each statement.

Results: The literature search produced 1,326 articles that met search criteria. After screening these articles for relevance and applying the inclusion criteria, 17 articles were chosen to be reviewed by the panel and assigned a level of evidence based on SORT criteria. The panel then created six consensus statements that received a unanimous vote for adoption.

Conclusion: While there are several options for the treatment of AK, there is little consensus on a standard of care. Clearance rates for the most common topical field therapies vary significantly but are also difficult to directly compare due to differences in methodology for measuring and assessing outcomes. Overall, it is clear that an efficacious, tolerable, and convenient treatment for AKs is critical to optimal adherence and management and, given the results of recent studies, tirbanibulin may be the best topical option for meeting these criteria.
Treatment of Severe Recalcitrant Atopic Dermatitis with Dupilumab in a Kidney Transplant Patient
Authors: Li Vivian , Guenin Sophie , Lebwohl Mark
Published: May 2023

This case report highlights the successful treatment of refractory atopic dermatitis (AD) in an immunosuppressed patient using dupilumab, a biologic agent that selectively targets cytokines crucial in the pathogenesis of AD. The patient had a history of failed treatment with numerous topical and systemic immunomodulating agents, including corticosteroids and immunosuppressive drugs for organ transplant. Dupilumab treatment resulted in significant improvement of symptoms, including reduced pruritus, and ultimately achieved disease control. Importantly, the patient experienced no adverse effects apart from one COVID-19 infection over three years of co-administration of dupilumab with immunosuppressive transplant rejection treatment. The safety of dupilumab in immunocompromised and transplant patients has been a concern, but studies have shown its safety and efficacy in these patient populations. This case highlights the potential for dupilumab as a safe and effective treatment option for patients with severe AD who are immunocompromised or have undergone solid organ transplantation.
Psoriatic Arthritis Flare in a Hospitalized Patient with Schizoaffective Disorder: A Case Report
Authors: Arora Puneet , Tomac Tracy
Published: May 2023

Psoriasis is a known comorbid condition in patients with schizophrenia spectrum disorders. Due to the nature of these psychiatric conditions, many experience lengthy hospitalizations and self-isolate at baseline, which can make identification and management of psoriasis difficult. We report the case of a middle-aged male with a history of schizoaffective disorder and treatment-resistant psoriatic arthritis who experienced a severe flare while hospitalized. His two-month hospital stay became complicated by combative behavior and continued medication refusal, resulting in repeated seclusion events and eventual transfer to a higher acuity unit. After treatment with ixekizumab and a course of prednisone was initiated one month after admission and symptom onset, the patient’s lesions were tremendously improved along with his mood on the unit. With the improvement in his chronic pain and discomfort, the patient was able to focus on mental health recovery and rapidly approached discharge. This report highlights the importance of appropriate management of comorbid conditions, especially psoriasis in patients with schizophrenia spectrum disorders needing long-term hospitalization. Additionally, this case demonstrates the successful use of ixekizumab in treatment-resistant psoriasis.
A Violaceous Mass of the Chest: An Unsuspected Diagnosis of Primary Ewing Sarcoma
Authors: Levin Adam , Guyara Armaan , Athalye Leela
Published: May 2023

Ewing Sarcoma is the second most common primary bone cancer. To date, only a few cases of primary cutaneous Ewing Sarcoma have been published. We present a unique case of primary cutaneous Ewing Sarcoma, which presented as a blue to violaceous mass on a young woman’s chest. The lesion clinically did not align with previous reports of primary cutaneous Ewing Sarcoma but pathology and immunohistochemical stains confirmed the diagnosis. Because primary cutaneous Ewing Sarcoma may masquerade as benign tumors, dermatologists must be suspicious of otherwise benign looking tumors.
A Case of a Large, Painful Dermatofibrosarcoma Protuberans Arising from a Traumatic Scar
Authors: Fischer Daniel , Litchman Graham
Published: May 2023

Here we report a case of dermatofibrosarcoma protuberans (DFSP) that presented originally to the emergency department with chief complaint of ‘chest pain arising from a chest wall mass’. This case is unique for multiple reasons including the fact that the DFSP caused this patient severe pain that radiated from the site of the mass to the patient’s back. The lesion originated from a traumatic scar that the patient had obtained following a car accident two years prior to presentation. In addition, the DFSP was significantly larger in size than what has typically been reported in the literature. This case illustrates that DFSP has the potential to present with multiple atypical features.
Disseminated Varicella-zoster Virus Infection in an Immunocompetent Host
Authors: Mulholland Alannah , Tang Brandon , Shumak Steven , Zhou Linda
Published: May 2023

Disseminated varicella-zoster virus (VZV) infection has devastating impacts on patients’ quality of life, with increasing morbidity and mortality. Thus, it is imperative that a diagnosis be made early. This case description illustrates a unique and dramatic presentation of disseminated VZV infection with important clinical implications.
Clinician- and Patient-Reported Outcomes with Tirbanibulin 1% Treatment for Actinic Keratosis in Routine Clinical Practice Across the U.S. (PROAK Study)
Authors: Schlesinger Todd , Kircik Leon , Del Rosso James , Rigel Darrell , Lebwohl Mark , Berman Brian , Armstrong April , Bhatia Neal , Patel Vishal A. , Narayanan Siva , Koscielny Volker , Kasujee Ismail
Published: May 2023

Background: Patients' experiences regarding topical actinic keratosis (AK) treatments may optimize clinical outcomes. PROAK study aimed to evaluate patient- and clinician-reported outcomes among adult patients with AK on face or scalp who were prescribed tirbanibulin in real-world clinical practice in the United States.

Methods: Key primary endpoint was quality of life (QoL) assessed by Skindex-16. Additional endpoints were tirbanibulin treatment effectiveness and satisfaction (Treatment Satisfaction Questionnaire for Medication and Expert Panel Questionnaire).

Results: 290 patients were included in this analysis. At week 8, Skindex-16 scores improved in all domains (mean change from baseline [standard deviation, SD]: -14.3 [27.8] in symptoms, -24.9 [33.0] in emotions, and -9.8 [23.7] in functioning domain). Clinicians and patients reported high global satisfaction with tirbanibulin (mean [SD] scores of 78.8 [20.1] and of 74.5 [23.5]). Overall skin appearance improved from baseline to week 8 (91.0% clinicians; 84.1% patients). In comparison with previous treatments, tirbanibulin had shorter skin reactions duration (89.2% clinicians; 73.9% patients); milder skin reaction severity (91.0% clinicians; 76.6% patients); better daily activities impact (87.4% clinicians; 64.0% patients); and was easier to use (88.3% clinicians; 71.2% patients).  Investigator’s Global Assessment (IGA) success (0-1) was achieved by 73.8% of the patients. Skin photodamage severity reduction from baseline to week 8 was significant (77.4% vs. 39.6%; p<0.0001).

Conclusions: Tirbanibulin treatment demonstrated effectiveness in AK management. Moreover, tirbanibulin improved QoL, as early as week 8, and both clinicians and patients reported tirbanibulin treatment convenience, and high levels of treatment satisfaction, compared to patient’s previous treatments.
Epidemiology and Mortality Risk Factors of Sebaceous Carcinoma: A SEER – Based Population Study
Authors: Haquang Joseph , Li Rocky , Mai Kevin , Chen Kuang Cheng , Sisan Fardad , YuLing Kuo
Published: May 2023

Background:

Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. It is derived from the adnexal epithelium of sebaceous glands and tends to hold a diverse clinical presentation. Although it is often reported in the periocular region, it can manifest from any sebaceous unit in the skin. Due to the rarity of this condition, prognostic and demographic factors are largely indeterminate. Hence, we sought to assess the prognostic impact of demographic and socioeconomic factors on the outcome of patients with sebaceous carcinoma.

 

Methods:

A retrospective analysis was performed utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database. From the registries, cases of sebaceous carcinoma from the years 2000 to 2018 were analyzed. Univariate and multivariate cox regression analyses were used to analyze the significance of socioeconomic and demographic factors on the survival of sebaceous carcinoma. Tumor grade and extent were included in the multivariate cox regression to minimize confounding.

 

Results:

A total of 4154 cases of sebaceous carcinoma were analyzed within this study. Socioeconomic and demographic factors analyzed includes age, sex, race, and income. On multivariate analysis including tumor grade, tumor extent, age, sex, race and income, African American race was a significant risk indicator for survival (hazard ratio [HR], 1.9; P=.007). Increased age of 70+ were also identified as a significant risk indicator for survival (HR, 5.86; P<0.001). Female sex was identified as a protective indicator for survival (HR, 0.82; P=0.03). Income status did not significantly influence the survival outcome of sebaceous carcinoma.

 

Conclusion:

Although income status did not show any significant influence on the survival outcome of sebaceous carcinoma, sex, race, and age characteristics did. The etiology behind these prognostic factors is unclear but may be related to access to medical care or lack of social support.
The Prevalence of Secondhand Smoke Exposure in Hidradenitis Suppurativa: A Cross-Sectional Survey Study
Authors: Weir Sydney , Ahmed Hana , Broughton Mia , Kole Lauren
Published: May 2023

Introduction
Hidradenitis Suppurativa (HS) is a chronic inflammatory disease of the skin highly associated with firsthand smoking. Secondhand smoke, defined as the inhalation of smoke from burning a tobacco product or smoke that is exhaled by smokers, and its relationship to HS has not been assessed. This study aims to determine the prevalence of secondhand smoke exposure in the HS population.
Methods
In this cross-sectional study (N=136), surveys were both administered in a dermatology clinic and emailed to patients with HS, verruca vulgaris (VV), and atopic dermatitis (AD). Control groups were selected based on secondhand smoke associations: AD has a known association, whereas VV does not.
Results
The survey response rate was 67.3% (N=136). We found that more than half of HS patients (58.73%) were exposed to secondhand smoke within the last 12 months, whereas 38.30% and 30.77% in the AD and VV groups were exposed, respectively (p=0.0209). Additionally, our data did not identify a significant correlation between secondhand smoke and HS disease severity.
Conclusion
Our study is the first to assess the prevalence of secondhand smoke exposure in the HS population. However, due to the limitations of the study design and significant differences between study groups, we were unable to assess the true association between HS and secondhand smoke exposure. While our study did not identify an increased prevalence of secondhand smoke exposure in the HS population, it highlights an area for further investigation evaluating the relationship between passive tobacco exposure and inflammatory skin disease.
Hidradenitis Suppurativa: A Cross-sectional Study of Content Quality on TikTok
Authors: Wescott Raquel , Dhami Ramneek , Wang Lingchen , Hovenic Whitney
Published: May 2023

Introduction: TikTok is a popular social media platform that is sometimes used to share medical information. 1 Creators share their experiences with or provide education regarding medical diagnoses. This study investigated the content quality of TikTok videos regarding hidradenitis suppurativa (HS).
Methods: On October 24, 2022, we searched #hidradenitissuppurativa on TikTok and filtered by most liked videos. Two independent reviewers analyzed the videos, excluding those not in English, irrelevant to HS, and duplicates. Videos were scored using the Global Quality Scale (GQS), 2 a one question scale (1-poor quality to 5-excellent quality), and the DISCERN tool, 3 a 16-question analysis (1-low quality to 5-high quality).
Results: One-hundred videos were included. The mean GQS score was 2.49 [SD 0.87] and mean DISCERN score was 1.98 [SD 0.52], with substantial interrater reliability (Cohen’s Kappa 0.667). Twenty-six videos (26%) were created by physicians and 74 (74%) were created by non-physicians. Mean GQS and DISCERN scores for physician versus non-physician videos were 3.40 and 2.62, and 2.16 and 1.75, respectively. Both GQS and DISCERN scores were greater for videos created by physicians versus non-physicians (p < 0.0001).
Conclusion: Overall, there is a lack of information on treatment benefits, risks, and mechanism of action. Given the mean GQS and DISCERN scores, the average video was of generally poor quality, creating potential for lack of knowledge and misinformation regarding HS. With the growing use of TikTok for educational purposes, improving content quality should be a priority to provide accurate information regarding medical conditions such as HS.
Comparison of patient and clinician satisfaction with tirbanibulin treatment’s ability to improve ‘how skin looks’ and ‘skin texture’ in the treated area, among patients with Actinic Keratosis treated with tirbanibulin in community practices across U.S.
Authors: Lebwohl Mark , Rigel Darrell , Schlesinger Todd , Armstrong April , Berman Brian , Bhatia Neal , Del Rosso James , Kircik Leon , Patel Vishal A. , Narayanan Siva , Koscielny Volker , Kasujee Ismail
Published: May 2023

Introduction: The objective of this analysis was to compare patient and clinician satisfaction with tirbanibulin treatment’s ability to improve ‘how skin looks’ and ‘skin texture’ in the treated area, among patients with Actinic Keratosis (AK) treated with tirbanibulin in community practices across the U.S. Methods: A single-arm, prospective cohort study (PROAK) was conducted among adult patients with AKs on the face or scalp who were newly initiated with once-daily tirbanibulin treatment (5-day course) in real-world community practices in the U.S, as part of usual care. Patients and clinicians completed surveys and clinical assessments at baseline, Week-8 (timeframe for main endpoints) and Week-24. Patient’s self-reported satisfaction and clinician satisfaction with tirbanibulin treatment’s ability to improve ‘how skin looks’ and ‘skin texture’ in the treated area at individual patient-level were assessed among study patients at Week-8 on a seven-point adjectival response scale of 1 (extremely dissatisfied) – 7 (extremely satisfied). Results: A total of 290 patients with AKs completed the study assessments at Week-8 (female: 31.38%; history of skin cancer: 61.72%; Fitzpatrick skin type: I: 7.59%, II: 71.38%, III: 18.62%, IV: 1.38%, V: 1.03%). Patient self-reported skin-texture at baseline was – dry: 39.66%, smooth: 47.59%, rough: 19.66%, bumpy: 18.62%, scaly: 35.17%, blistering/peeling: 6.55%. All patients (100%) completed their 5-day once-daily treatment course. At Week-8, 75.86% & 78.97% of the patients and clinicians respectively reported extremely/very/satisfied with tirbanibulin’s ability to improve ‘how skin looks’, while 14.14% & 14.14% respectively reported somewhat satisfied, and 10.00% & 6.55% respectively reported extremely/very/dissatisfied. At Week-8, 74.83% & 80.69% of patients and clinicians respectively reported extremely/very/satisfied with tirbanibulin’s ability to improve their ‘skin texture’, while 15.52% & 12.41% respectively reported somewhat satisfied, and 9.65% & 6.55% respectively reported extremely/very/dissatisfied. Conclusion: A majority of patients with AKs and their clinicians reported satisfaction with the ability of 5-day treatment course of tirbanibulin to improve ‘how skin looks’ or ‘skin texture’ in the tirbanibulin-treated area, at Week-8.
Subtype performance of the ancillary diagnostic 23- and 35-gene expression profile (GEP) tests for difficult-to-diagnose melanocytic lesions
Authors: Plaza Jose A , Estrada Sarah I , Russell Brooke H , Siegel Jennifer J , Rogers Jason , Wilkinson Jeffrey K , Kurley Sarah J , Goldberg Matthew S , Motaparthi Kiran
Published: May 2023

Background: Histopathological examination is adequate for most melanocytic neoplasms; however, there is a subset of lesions that are difficult to diagnose. The 23- and 35-gene expression profile (GEP) tests deliver results of suggestive of benign neoplasm, suggestive of malignant neoplasm, or intermediate (cannot exclude malignancy). They are intended to provide clinicians with objective results to be interpreted in the context of clinical, laboratory, and histopathological features to achieve a definitive diagnosis. Both GEPs are stand-alone tests that are independently validated and clinically available. Greater than 99% benign or malignant reporting is achieved clinically when the 23-GEP test is processed first, and if an intermediate result or test failure occurs, the 35-GEP is utilized.

Methods: The performance of the 23- and 35-GEP tests using this methodology was tested on unequivocal cases from a variety of subtypes (101 benign, 249 malignant). Lesions were included if 2/3 dermatopathologist diagnoses were concordant. Subtype designation was determined by the dermatopathologist that submitted the lesion for the study.

Results: The overall accuracy metrics in this cohort were 96.0% sensitivity and 87.8% specificity. The results demonstrated 100% sensitivity in several melanoma subtypes including acral lentiginous (n=15), desmoplastic (n=20), melanoma in situ (n=16), and nevoid (n=16). Other melanoma subtypes showed sensitivity metrics of: lentigo maligna, 96.7% (n=31); nodular, 95.1% (n=81); superficial spreading, 97.7% (n=42); and spitzoid, 85.0% (n=20). Subtypes of benign nevi showed a specificity of: blue, 96.7% (n=30); compound, 85.7% (n=42); junctional, 77.8% (n=18); and Spitz, 100% (n=7).

Conclusions: Overall, we demonstrate that use of the 23- and 35-GEP diagnostic test workflow results in high accuracy across many subtypes of benign and malignant melanocytic neoplasms.

Financial Disclosures: JAP has served as a consultant for Castle Biosciences, Inc. SIE is a consultant and shareholder of Castle Biosciences, Inc. BHR, JJS, JHR, JKW, SJK, and MSG are employee shareholders of Castle Biosciences, Inc. KM has served as a consultant and investigator for studies supported by Castle Biosciences, Inc. This study was supported by Castle Biosciences, Inc.
Association of TGFB3 and FGFs gene polymorphisms with cleft lip with or without cleft palate a systematic review
Authors: Quizhpi-Quito Andrea Soledad , Caparó Ebingen Villavicencio , Bravo-Calderón Diego Mauricio
Published: May 2023

Objectives:

The objective of this study was to conduct a systematic review of the possible association between transforming growth factor B3 (TGFB3) and fibroblast growth factors (FGFs) gene polymorphisms and nonsyndromic cleft lip with or without cleft palate (NSCL/P).

Material and Methods:

Two reviewers independently screened studies by examining all titles and abstracts. Studies were included if they met the following criteria: The outcome of interest was NSCL/P; the polymorphisms studied were TGFB3 and FGF; they presented sufficient data, that is, allele/genotype frequency between cases and controls; or their odds ratio with 95% confidence interval. Study quality was independently assessed by a risk of bias assessment for genetic association studies.

Results:

Based on the inclusion criteria, we have selected a total of six articles (four for TGFB and two for FGF). Particularly for the TGFB gene, we have found significant results in exon 4 in the variant g.15812T>G, and in the single-nucleotide polymorphisms rs2300607 A/T, in the distribution between cases and controls. On the other hand, for the FGF gene, we observed a statistically significant in the genotype rs34010 CA.

Conclusion:

None of the genetic variations that show the association is verified in different populations; therefore, there is not enough scientific validation regarding the association between TGFB and FGF polymorphism and NSCL/P. The findings of the different studies suggest the need for further investigations with samples composed of a larger number of individuals in different populations, which should be performed with all the standards for genetic studies, thus allowing an understanding of the molecular basis of the disease.