bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender Gaps in Strategies for Maintaining the Social Participation and Interaction of Older Adults with People in a Local Community
Authors: Nomura Kenta , Kobayashi Norikazu
Published: May 2024

Purpose. This study aims to elucidate the gender gaps in the strategies for maintaining the social participation and interaction of older adults with people in a local community. Methods. The subjects were 130 older adults aged 65 years or older and independently living in their homes in Saitama, Saitama Prefecture, Japan. The authors conducted an anonymous questionnaire survey on paper and performed multiple regression analysis for men and women separately using the Lubben Social Network Scale‐6 (LSNS‐6) as the dependent variable. Results. Among the independent variables used for the analysis, those that significantly influenced LSNS‐6 in men were social activities related to the daily life satisfaction of the elderly (SARDS). The independent variables that significantly influenced LSNS‐6 in women were SARDS, sense of coherence‐13 (SOC‐13), and the number of family members living with the subjects. Discussion. Health promotion is not associated with interaction with people in men compared with women.
In Vivo Antidiarrheal Potential of the Leaf Extract of Maytenus addat (Loes.) Sebsebe and Its Major Compound
Authors: Mogose Bonsa , Bisrat Daniel , Asres Kaleab
Published: May 2024

Diarrhea continues to be one of the top causes of death in children under the age of five, particularly in developing nations. In Ethiopian traditional medicine, a variety of medicinal plants are used to treat diarrhea. One of these plants is Maytenus addat (Loes.) Sebsebe (fam. Celastraceae), which is endemic to the Afromontane forests, especially along forest margins, of Ethiopia. The air-dried powdered leaves of M. addat were macerated with 80% methanol to yield a crude extract. Additionally, the powdered plant material underwent sequential solvent extraction using chloroform, methanol, and water to obtain solvent fractions. The 80% methanol leaf extract, solvent fractions, and an isolated compound from M. addat were evaluated for their antidiarrheal activity using castor oil-induced diarrheal model, anti-enteropooling test, and charcoal meal test in mice. The results showed that the 80% methanolic leaf extract significantly reduced the onset of diarrhea, the weight of feces, and the frequency of defecation in all the tested doses. The methanol and water fractions of the hydroalcoholic extract also exhibited dose-dependent antidiarrheal activity, with the methanol fraction showing the highest activity at 400 mg/kg dose. Subsequently, the most active methanol fraction was subjected to C-18 solid phase extraction, resulting in the isolation of a 3-hydroxyflavone, identified as quercetin by ESI-qToF-MS, 1H, and 13C-NMR spectroscopic techniques. Quercetin demonstrated a strong antidiarrheal activity in a dose-dependent manner. Thus, the present study provided evidence that the leaves of M. addat possess genuine antidiarrheal activity upholding the traditional medicinal use of the plant for the treatment of diarrhea. The findings also suggest that quercetin is responsible, in full or in part, for the activity of the plant.
Resilience and Flexibility for Clinical Nurses: A Latent Class Analysis
Authors: Zhao Shuang , Zhang Zeyu , Duan Xiaocui , Shao Yujiao , Wang Fuzhi , Chen Yongxia , Yang Congyan , Chen Lingling , Wang Fei , Zhang Jiaoping , Zhang Hailing , Yang Xiumu , Yuan Changjiang
Published: May 2024

Aim. To explore potential resilience and psychological flexibility patterns in nurses and analyze the effects of related factors such as growth mindset and professional recognition of categories. Background. Resilience and psychological flexibility can help nurses resist occupational pressure and play essential roles in promoting personal growth and professional development. Methods. A latent category approach was used to examine the patterns of heterogeneity in resilience and flexibility among 805 nurses. Differences in the influences related to resilience and flexibility were analyzed using univariate and multivariate logistic regressions, with demographic information, growth mindset, and career recognition as covariates. Results. Participants were divided into three potential categories: toughness-flexible (32.8%), power-deficit-emotional (23.1%), and toughness-rigid (44.1%). The results of multivariate logistic regression analysis showed that monthly income, mode of employment, growth mindset, and professional identity were influential factors in the potential categories of nurse resilience and flexibility. Conclusion. One cohort of nurses had high resilience and low flexibility, and psychological rigidity was related to the fact that the monthly income was less than RMB 5,000 and the contractual mode of employment. An excellent growth mindset and a high professional identity indicate that nurses are resilient and flexible. Implications for Nursing Management. Hospitals and nursing managers should pay attention to nurses’ different career development needs and implement appropriate safeguards.
TABLE 1 from A Phase II Study of ERK Inhibition by Ulixertinib (BVD-523) in Metastatic Uveal Melanoma
Authors: Buchbinder Elizabeth I. , Cohen Justine V. , Tarantino Giuseppe , Lian Christine G. , Liu David , Haq Rizwan , Hodi F. Stephen , Lawrence Donald P. , Giobbie-Hurder Anita , Knoerzer Deborah , Sullivan Ryan J.
Published: May 2024

Baseline characteristics
Supplementary table 2 from A Phase II Study of ERK Inhibition by Ulixertinib (BVD-523) in Metastatic Uveal Melanoma
Authors: Buchbinder Elizabeth I. , Cohen Justine V. , Tarantino Giuseppe , Lian Christine G. , Liu David , Haq Rizwan , Hodi F. Stephen , Lawrence Donald P. , Giobbie-Hurder Anita , Knoerzer Deborah , Sullivan Ryan J.
Published: May 2024

Supplementary table 2: All adverse events/toxicities regardless of attribution
Supplementary table 1 from A Phase II Study of ERK Inhibition by Ulixertinib (BVD-523) in Metastatic Uveal Melanoma
Authors: Buchbinder Elizabeth I. , Cohen Justine V. , Tarantino Giuseppe , Lian Christine G. , Liu David , Haq Rizwan , Hodi F. Stephen , Lawrence Donald P. , Giobbie-Hurder Anita , Knoerzer Deborah , Sullivan Ryan J.
Published: May 2024

Supplementary table 1: Representativeness of study participants
Autosomal dominant Weill-Marchesani-like syndrome in a Chinese family due to novel haplotypic mutations in LTBP2
Authors: Chen Juan , Wan Jifeng , Jin Jiayi , Jin Guangming , Zheng Yongxin , Zheng Danying , Zhong Liuxueying
Published: May 2024

Introduction: Weill-Marchesani syndrome (WMS) is a hereditary connective tissue disorder with substantial heterogeneity in clinical features and genetic etiology, so it is essential to define the full mutation spectrum for earlier diagnosis. In this study, we report Weill-Marchesani-like syndrome (WMS-like) change to autosomal dominance inheritance caused by novel haplotypic mutations in latent transforming growth factor beta-binding protein 2 (LTBP2).
Methods: Twenty-five members from a 4-generation Chinese family were recruited from Guangzhou, of whom nine were diagnosed with WMS-like disease, nine were healthy, and seven were of “uncertain” clinical status because of their young age. All members received detailed physical and ocular examinations. Whole exome sequencing, Sanger sequencing, and real-time PCR were used to identify and verify the causative mutations in family members.
Results: Genetic sequencing revealed novel haplotypic mutations on the same LTBP2 chromosome associated with WMS-like, c. 2657C>A/p.T886K in exon 16 and deletion of exons 25-36. Real-time PCR and Sanger sequencing verified both mutations in patients with clinically diagnosed WMS-like, and in one “uncertain” child. In these patients, the haplotypic mutations led to ectopia lentis, short stature and obesity.
Conclusion: Our study revealed that WMS-like may be associated with haplotypic LTBP2 mutations with autosomal dominant inheritance.
Large Language Models and the Wisdom of Small Crowds
Authors: Trott Sean
Published: May 2024

Recent advances in Large Language Models (LLMs) have raised the question of replacing human subjects with LLM-generated data. While some believe that LLMs capture the “wisdom of the crowd”—due to their vast training data—empirical evidence for this hypothesis remains scarce. We present a novel methodological framework to test this: the “number needed to beat” (NNB), which measures how many humans are needed for a sample’s quality to rival the quality achieved by GPT-4, a state-of-the-art LLM. In a series of pre-registered experiments, we collect novel human data and demonstrate the utility of this method for four psycholinguistic datasets for English. We find that NNB > 1 for each dataset, but also that NNB varies across tasks (and in some cases is quite small, e.g., 2). We also introduce two “centaur” methods for combining LLM and human data, which outperform both stand-alone LLMs and human samples. Finally, we analyze the trade-offs in data cost and quality for each approach. While clear limitations remain, we suggest that this framework could guide decision-making about whether and how to integrate LLM-generated data into the research pipeline.
Humboldtian Science and Humboldt’s science
Authors: Daum Andreas W.
Published: May 2024

This article investigates why Humboldtian Science, as a heuristic concept, has gained prominence in the historiography of science and requires clarification. It offers an ideal-type model of comparative research and exact measurements across vast spaces, which Susan F. Cannon and others tied to Alexander von Humboldt (1769–1859). Yet, he himself was less “Humboldtian” than this concept suggests. The article proposes to disentangle Humboldtian Science from Humboldt’s science, which constituted a set of individual research practices that defied the ideal of precision. Humboldt’s science was often impromptu, marked by epistemological and personal insecurities, and embedded in the protagonist’s peripatetic way of living and frequently erratic writing style. Historicizing Humboldt’s science undermines the exceptionalism that elevates the Prussian savant above his contemporaries and casts him as a singular figure. This critical reflection encourages biographical approaches to the history of science, balancing heuristic generalizations and attention to individual research styles.
Fostering effective collaboration between library and information science academics and practitioners in Bangladesh: Insights, challenges and recommendations
Authors: Roy Prodip , Habib Md. Ahasan
Published: May 2024

Effective collaboration between library and information science academics and practitioners is vital for the professional growth and success of individuals working in the field. It facilitates the exchange of knowledge, skills and innovative practices, which, in turn, enhance the quality of library services. It allows for the integration of theoretical knowledge with practical experience, resulting in more effective and efficient library operations. However, the lack of studies on fostering collaboration between library and information science academics and practitioners in Bangladesh presents a notable research gap. Addressing this gap is critical as it directly impacts the career success of library and information science professionals and the development of library services, particularly in a rapidly developing nation like Bangladesh. This study utilized a qualitative approach to gather data through semi-structured, unstructured, and focus group interviews with renowned Bangladeshi academics and experienced library practitioners. The research has broader implications for the global library and information science community, adding a valuable perspective from a developing nation. The results highlight the significance of mindset and attitude in influencing collaborative efforts, urging academics and practitioners to adopt an open-minded approach without ego-related conflicts. The study identifies the strengths, weaknesses, barriers and opportunities in relation to effective collaboration between library and information science academicians and practitioners. Additionally, the research proposes viable solutions and outlines the potential for academic and professional success through collaboration.
Preparation and mechanism of fly ash based composite fillers with different morphologies and its application in filling polyamide 6
Authors: Li Haiting , Wang Caili , Wang Bin , Yao Guoxin , Zhao Chunxue , Shu Chang , Yang Runquan
Published: May 2024

In order to realize the high value-added utilization of coal-based solid waste fly ash (FA) and enhance the performance of polyamide 6 (PA6), three kinds of core-shell structure FA-based composite fillers with different shell morphologies (nano-flake, spherical and rod-like particles) were prepared using FA as raw material, MgSO4, MgCl2, Mg(NO3)2 and NaOH as coating agents, which were noted as composite powder 1 (CP1), composite powder 2 (CP2) and composite powder 3 (CP3). The specific surface areas were enhanced to 97.41, 58.59 and 20.21 m2 g−1 from 1.71 m2 g−1 (FA), while the corresponding pore volumes were increased from 0 to 0.31, 0.22 and 0.06 cm3 g−1. Si-O-C-O-Mg and Si-O-Mg-OH bonds were formed between Si-O-Si, Si-O bonds on the surface of FA and hydrated MgCO3 (MCH), Mg(OH)2 (MH). Three types of CPs were filled into PA6, respectively. After filling, CP2 caused silver grain effect when the material was damaged, which had better toughening effect on the matrix. Compared with pure PA6, the limiting oxygen index of pure MH, FA, CP1, CP2, and CP3 increased by 0.60, 0.70, 1.30, 2.30 and 4.10%, respectively. The thermal deformation temperature was increased by 29.10, 46.20, 53.70, 31.90 and 42.00°C respectively. The melting index decreased by 1.05, 0.70, 0.49, 0.17 and 0.47 g/min, respectively.
Evolution of the Household Debt Narrative: A PRISMA-compliant Systematic Literature Review
Authors: Joo Bashir Ahmad , Ishaq Mir Simtiha
Published: May 2024

This article focuses on the narratives that are developing in the household debt arena through a systematic and in-depth examination of the literature. The article used co-occurrence analysis to identify the major themes in the household debate followed by a review of the top 100 highly cited articles, which is supplemented with citation tracking. It is found that the past research mainly concentrates on the effect of financialization and deregulation of global markets, mortgages and housing bubbles, the upward trending inequality, the GDP growth and financial stability as well as the relationship between the household balance sheet and macroeconomic fluctuations. This study highlights the significant and upcoming trends in the study of household finances placing it at the centre of academic discourse on economic crisis and financial stability. It tracks the channels through which household debt could have potential impact on economic stability by summarizing the significant studies and deriving conclusions and direction for future research.
Future of Pharmaceutical Industry: Role of Artificial Intelligence, Automation and Robotics
Authors: T. Manoj Kumar , B. Preethi , Nunavath Raja Shekhar , Nagappan Krishnaveni
Published: May 2024

Background

The future of smart factories and pharmaceutical industries has evolved significantly since the 19th century. Computers have been used in the pharmaceutical field since the 1980s with the emergence of Artificial Intelligence (AI). In addition, automation and robotics are used in the pharmaceutical industry to improve the efficiency of pharmaceutical development and production.

Purpose

The present review article covers the future roles of AI, automation and robotics in pharmaceutical industries.

Methodology

The current review article employed a comprehensive search strategy across relevant databases, including PubMed, Scopus and Web of Science, utilizing keywords such as AI, Automation, Robotics and Pharmaceutical Industries. The articles considered a focus on recent advancements and emerging trends in the intersection of AI, automation and robotics within pharmaceutical sectors.

Results

AI, incorporating predictive machine learning and reasoning techniques, aids in the preclinical identification of molecules and forecasting potential lead compounds before conducting clinical trials. automation offers significant benefits in monitoring and predictive maintenance of production lines, power distribution and control machines. Robotic process automation improves efficiency by connecting computer terminals to handle various manufacturing process elements.

Conclusion

Artificial intelligence, automation and Robotics have sparked innovations in the healthcare business, benefiting the global ecosystem and healthcare delivery. Incorporating these advanced tools in pharmaceutical industries from raw material selection to final product development could improve the quality and safety of the pharmaceutical products and reduce the time and cost.
Assessment of the effect of gabapentin on blood pressure in cats with and without chronic kidney disease
Authors: Quimby Jessica M , Jones Sarah E , Saffire Ashlie , Brusach Katelyn K , Kurdziel Kim , George Zach , Paschall Rene E , Aarnes Turi K
Published: May 2024

Objectives

The aim of the present study was to assess the effect of gabapentin on blood pressure (BP) in cats with and without chronic kidney disease (CKD).

Methods

A randomized, blinded, placebo-controlled crossover study was performed. A total of 29 cats were included: 13 cats with stable CKD (IRIS stage 2–4) and 16 apparently healthy cats (serum creatinine <1.6 mg/dl and urine specific gravity >1.035). The cats were evaluated twice, approximately 1 week apart, and BP (Doppler sphygmomanometry) was obtained 3 h after cats received either a single dose of gabapentin 10mg/kg PO or placebo. For each cat, BP readings were obtained at each visit using the same Doppler and sphygmomanometer unit, and the same cat holder and Doppler operator, in the same location.

Results

After administration of a single dose of gabapentin (10 mg/kg PO), BP was significantly lower (median 122 mmHg, range 82–170) than after administration of the placebo (median 150 mmHg, range 102–191; P = 0.001). In the CKD subgroup, BP was significantly lower after administration of gabapentin (median 129 mmHg, range 96–170) than after administration of the placebo (median 155 mmHg, range 102–191; P = 0.008). In the healthy cat subgroup, BP was significantly lower after administration of gabapentin (median 121 mmHg, range 82–139) than after administration of the placebo (median 137 mmHg, range 102–177; P = 0.002). The median change in BP was −12 mmHg (range −95 to 10) for healthy cats and −12 mmHg (range −43 to 21) for cats with CKD (no significant difference between subgroups).

Conclusions and relevance

Gabapentin may decrease arterial BP in cats with and without CKD and these findings should be taken into account when gabapentin is administered to patients in which measurement of BP is needed.
Early surgery within 48 hours of admission for hip fracture did not improve 1-year mortality in Japan: a single-institution cohort study
Authors: Iida Hiroki , Takegami Yasuhiko , Sakai Yoshihito , Watanabe Tsuyoshi , Osawa Yusuke , Imagama Shiro
Published: May 2024

Introduction:

Early surgery for hip fracture, within 48 hours of hospital admission, is effective in reducing mortality. However, the average preoperative waiting time for hip fractures in Japan is 4.5 days and the 1-year mortality rate after a hip fracture is 10% in Japan. This study aimed to investigate whether early surgery, within 48 hours, could reduce the 1-year mortality rate in patients with hip fractures in Japan.

Methods

This cohort study involved 402 consecutive patients with hip fractures who underwent surgical treatment between January 2013 and September 2019. The exclusion criteria were an age of <60 years and in-hospital injury. A total of 389 patients were included in this study. The patients were divided into two groups: those who underwent early surgery within 48 hours of admission (early group) and those who di not undergo early surgery (delayed group). We compared patient characteristics and treatment outcomes between the 2 groups.

Results:

A comparison of patient characteristics revealed that the early group had lower hemoglobin levels (P=0.046), lower C-reactive protein levels ( P = 0.031), lower numbers of patients with weekend hospitalization, lower numbers of patients with a history of using medications that may cause bleeding ( P < 0.01), and who received general anaesthesia ( P < 0.01). However, there were no significant differences with regard to the other variables between the 2 groups. A treatment outcome analysis showed that the early group had shorter waiting times for surgery ( P < 0.01) and shorter stays in acute-care wards ( P < 0.01). However there were no differences in the total hospital stay, Barthel index at discharge, home discharge rates, in-hospital mortality rates, and 1-year mortality.

Conclusion:

Our findings indicate that early surgery did not reduce the 1-year mortality rate in older patients with hip fractures in Japan.
Commemorating Stolen Generation experiences through virtual reality
Authors: Tiwari Reena , Stephens John Richard , Scott (Noongar) Kim John , Parnell Renee , Morrison (Minang) James , Hussein Fatmaelzahraa Fekry Mohamed
Published: May 2024

State sanctioned removal of Australian Aboriginal children from family, culture, and country has had harmful and traumatic effects on the Survivors of this process and their children. Known as the Stolen Generations, children were detained in government settlements and church missions and stripped of Aboriginality. This article explores ways that a virtual reality reconstruction of mission environments may be implemented to memorialise and commemorate Survivor experience that avoid narratives of victimhood and destructive post-colonial overlays on their stories of survival. Our project is to develop a virtual reality model of Carrolup-Marribank Mission in Western Australia as a living digital memorial for use by Survivors and their families to help address their displacement and loss of culture and identity. This article shows how virtual reality may be a potent didactic tool to convey difficult histories as well as a purveyor of powerful stories that contest stereotyped perceptions of Aboriginal people.
Not playing the game: Political talk, hybridity and performance
Authors: Higgins Michael , Smith Angela
Published: May 2024

This article looks at two prominent news interviews by non-political actors; one an accountability interview and the other part of a panel discussion. It shows how the exchanges contest the conventions of the journalistic interview, deploying a range of unorthodox verbal and non-verbal tactics. The accountability interview, broadcast on Sky News and posted on X (Twitter), includes a heightened performative component, using a variety of techniques to foreground verbal and embodied incredulity. This attracted widespread public and journalistic comment, and produces a manner of engagement that evades conventional language analysis. Performance is a still more prominent factor in the second example, which analyses an appearance by a professional comedian on a BBC political discussion programme. This sustains a comedic persona based upon an enactment of mock-sincerity, contesting the conventional forms of mediated political talk and commentary. Together, these performances are assessed in the context of increasing hybridity in broadcast news, and the article suggests their significance extends beyond their status as sharable media spectacle, such that they show how popular forms of performance can challenge the institutional norms of neutralism.
A critical analysis of the research evidence behind CAST’s universal design for learning guidelines
Authors: Boysen Guy A
Published: May 2024

Universal Design for Learning (UDL) is a highly influential source of educational policy. CAST, a nonprofit educational organization, created UDL guidelines that they claim have a basis in research on learning, cognitive psychology, and the brain. The purpose of the current research was to evaluate the empirical studies cited on CAST’s UDL website as support for its guidelines. This review sampled articles provided as evidence for three UDL guidelines and analyzed their relation to choice, learning, and brain function. Results indicated that the cited studies provided little evidence for claims about UDL. Most of the studies did not offer a choice to learners or measure learning. None of the studies were related to brain function. Rather than supporting CAST’s UDL guidelines about the choice of multiple means of learning, the studies mostly provided support for single, effective instructional techniques. Overall, this study suggests that the cited evidence behind CAST’s UDL guidelines is weak and both basic research and implementation research are needed to establish the framework’s validity and effectiveness.
A Potential Pitfall of Passion: Passion Is Associated With Performance Overconfidence
Authors: Bailey Erica R. , Krautter Kai , Wu Wen , Galinsky Adam D. , Jachimowicz Jon M.
Published: May 2024

Having passion is almost universally lauded. People strive to follow their passion at work, and organizations increasingly seek out passionate employees. Supporting the benefits of passion, prior research finds a robust relationship between passion and higher levels of job performance. At the same time, this research also reveals significant variability in the size of the effect. To explain this heterogeneity, we propose that passion is associated with performance overconfidence—inflated views about how well the self is performing—and that this association provides a helpful lens in understanding when passion will be more or less beneficial for performance. A daily diary field study with 829 employees (33,160 observations) and an experiment with 396 participants provide evidence that passion is associated with performance overconfidence. These findings provide a lens through which to discuss when, why, and for whom passion may be more helpful for performance or a potential pitfall.
Women Empowerment Status in the Coastal Fishing Communities of Bangladesh
Authors: Rahman Md. Wakilur , Haque A. B. M. Mahfuzul , Zaman Tasnuva , Palash Md. Salauddin , Nahiduzzaman Md. , Nazia Tanzina
Published: May 2024

Socially ascribed gender norms are a significant barrier for women of the fishing communities in coastal Bangladesh. These norms limit women’s income autonomy, access to productive resources, decision making capacity and mobility, which negatively affects their economic empowerment and overall well-being. The article delves into the topic of women’s empowerment in these communities. The study employed a mixed method approach to collect data from ECOFISH II project intervention villages. Pro-WEFI, which is a modified and refined version of the Women’s Empowerment in Agriculture Index (WEAI) was utilized for fishing community to determine women’s empowerment and disempowerment status across three domains of empowerment (3DE): intrinsic, instrumental, and collective agency. The findings revealed that men experienced fewer inadequacies than women, with a weighted average 3DE score of 0.75 for men and 0.57 for women, and only 14% of women and 37% of men were found to be empowered. The Gender Parity Index (GPI) score was 0.79 and households with gender parity made up 31% of the total. This study developed a comprehensive set of Pro-WEFI indicators applicable for assessing and comparing women’s empowerment across cultures in fisheries-related projects. Utilizing the disaggregated scores of each Pro-WEFI indicator, it is possible to identify areas of disempowerment for both genders and prioritize project interventions accordingly. Furthermore, employing the Pro-WEFI tool in a longitudinal panel design can capture the changes in women’s empowerment over time in any fisheries project.
Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study
Authors: Chen Zhengwei , Liu Yueji , Lin Cunxin , Li Zhining , Shan Junjun , Duan Zuowei , Rong Liangqun , Wei Xiue , Xiao Lijie , Liu Haiyan
Published: May 2024

Background

Prior neuroimaging studies on vestibular migraine (VM) have extensively certified the functional and structural alterations in multiple brain regions and networks. However, few studies have assessed the cerebral blood flow (CBF) in VM patients using arterial spin labeling (ASL). The present study aimed to investigate CBF and functional connectivity (FC) alterations in VM patients during interictal periods.

Methods

We evaluated 52 VM patients and 46 healthy controls (HC) who received resting-state pseudo-continuous ASL and functional magnetic resonance imaging (fMRI) scanning. Comparisons of voxel-based CBF and seed-based FC were performed between the two groups. Brain regions showed significant group differences in CBF analyses were chosen as seeds in FC analyses. Additionally, the associations between abnormal imaging results and clinical features were explored.

Results

Compared with HC, VM patients showed higher normalized CBF in the right precentral gyrus (PreCG), left postcentral gyrus (PostCG), left superior frontal gyrus and bilateral insular (p < 0.05, FDR corrected). Furthermore, VM patients exhibited increased FC between the right PreCG and areas of the left PostCG, left cuneus and right lingual gyrus (p < 0.05, FDR corrected). In addition, we observed decreased FC between the left insular and regions of the left thalamus and right anterior cingulate cortex, as well as increased FC between the left insular and right fusiform gyrus in VM patients (p < 0.05, FDR corrected). Moreover, these variations in brain perfusion and FC were significantly correlated with multiple clinical features including frequency of migraine symptoms, frequency of vestibular symptoms and disease duration of VM (all p < 0.05).

Conclusions

Patients with VM during interictal period showed hyperperfusion and abnormal resting-state FC in brain regions potentially contributed to disrupted multi-sensory and autonomic processing, as well as impaired ocular motor control, pain modulation and emotional regulation. Our study provided novel insights into the complex neuropathology of VM from a CBF perspective.
Unlocking genetic insights: Evaluating wheat RILs for physiobiochemical traits under terminal heat stress conditions
Authors: Redhu Mandeep , Singh Vikram , Kumari Anita , Munjal Renu , Yashveer Shikha , Nimbal Somveer , Niwas Ram , Verma Swati , Sharma Kritika , Loyal Atul , Chawla Rukoo , Pati Rutuparna , Singh Chetan , Rahimi Mehdi
Published: May 2024

Background

The increasing impacts of heat stress on wheat production due to climate change has entailed the development of heat-resilient crop varieties. To address this, two hundred recombinant inbred lines (RILs) derived from a cross between WH711/WH1021 were evaluated in a randomized block design (RBD) with two replications at CCSHAU, Hisar, during 2018-19 under heat stress and non-stress conditions. Heat stress was induced by altering the date of sowing so that the grain filling stage coincide with heat stress.

Results

Heat stress adversely affects RILs performance, as illustrated by alterations in phenotypic traits. Highest coefficients of variations were recorded for TAA, CTD 1, WUE, CTD 2, Cc and A under non-stress and heat stress conditions whereas gs, WUEi and GY under non-stress and SPAD 1, SPAD 2, GY and NDVI 2 under heat-stress conditions recorded moderate estimates of coefficient of variations. CTD 2, TAA, E, WUE and A displayed a significant occurrence of both high heritability and substantial genetic advance under non-stress. Similarly, CTD 2, NDVI 2, A, WUEi, SPAD 2, gs, E, Ci, MDA and WUE exhibited high heritability with high genetic advance under heat-stress conditions.

Conclusions

Complementary and duplicate types of interactions with number of controlling genes were observed for different parameters depending on the traits and environments. RILs 41, 42, 59, 74, 75, 180 and 194 were categorized as heat tolerant RILs. Selection preferably for NDVI 1, RWC, TAA, A, E and WUEi to accumulate heat tolerance favorable alleles in the selected RILs is suggested for development of heat resilient genotypes for sustainable crop improvement. The results showed that traits such as such as NDVI, RWC, TAA, A, E, and WUEi, can be effective for developing heat-resilient wheat genotypes and ensuring sustainable crop improvement.
Genome-wide association study for seedling heat tolerance under two temperature conditions in bread wheat (Triticum aestivum L.)
Authors: Fu Chao , Zhou Ying , Liu Ankui , Chen Rui , Yin Li , Li Cong , Mao Hailiang
Published: May 2024

Background

As the greenhouse effect intensifies, global temperatures are steadily increasing, posing a challenge to bread wheat (Triticum aestivum L.) production. It is imperative to comprehend the mechanism of high temperature tolerance in wheat and implement breeding programs to identify and develop heat-tolerant wheat germplasm and cultivars.

Results

To identify quantitative trait loci (QTL) related to heat stress tolerance (HST) at seedling stage in wheat, a panel of 253 wheat accessions which were re-sequenced used to conduct genome-wide association studies (GWAS) using the factored spectrally transformed linear mixed models (FaST-LMM). For most accessions, the growth of seedlings was found to be inhibited under heat stress. Analysis of the phenotypic data revealed that under heat stress conditions, the main root length, total root length, and shoot length of seedlings decreased by 47.46%, 49.29%, and 15.19%, respectively, compared to those in normal conditions. However, 17 varieties were identified as heat stress tolerant germplasm. Through GWAS analysis, a total of 115 QTLs were detected under both heat stress and normal conditions. Furthermore, 15 stable QTL-clusters associated with heat response were identified. By combining gene expression, haplotype analysis, and gene annotation information within the physical intervals of the 15 QTL-clusters, two novel candidate genes, TraesCS4B03G0152700/TaWRKY74-B and TraesCS4B03G0501400/TaSnRK3.15-B, were responsive to temperature and identified as potential regulators of HST in wheat at the seedling stage.

Conclusions

This study conducted a detailed genetic analysis and successfully identified two genes potentially associated with HST in wheat at the seedling stage, laying a foundation to further dissect the regulatory mechanism underlying HST in wheat under high temperature conditions. Our finding could serve as genomic landmarks for wheat breeding aimed at improving adaptation to heat stress in the face of climate change.
Circulating trimethylamine N-oxide is correlated with high coronary artery atherosclerotic burden in individuals with newly diagnosed coronary heart disease
Authors: Bao Minghui , Li Haotong , Li Jianping
Published: May 2024

Background

Trimethylamine N-oxide (TMAO) is a metabolite derived from the gut microbiota and has been reported to be correlated with cardiovascular diseases. Although TMAO is associated with the severity of coronary artery disease in subjects with coronary heart disease (CHD) history. However, the correlation between TMAO and the atherosclerotic burden in newly diagnosed cases of CHD is unknown.

Methods

In this hospital-based study, we enrolled 429 individuals newly diagnosed with CHD undergoing coronary angiography. Plasma TMAO was assessed before coronary angiography. SYNTAX score was computed during coronary angiography to estimate the coronary artery atherosclerotic burden. Both linear and logistic regression analyses were conducted to explore the correlation between plasma TMAO levels and SYNTAX score in newly diagnosed CHD population.

Results

The TMAO in patients with SYNTAX ≥ 33 and subjects with SYNTAX < 23 were 6.10 (interquartile range [IQR]: 3.53 to 9.15) µmol/L and 4.90 [IQR: 3.25 to 7.68] µmol/L, respectively. Linear regression adjusting for traditional risk factors showed TMAO level was positively correlated with SYNTAX score (β = 0.179; p = 0.006) in CHD population. When TMAO was added to models with traditional risk factors, the predictive value improved significantly, with the receiver operating characteristic curve (AUC) increased from 0.7312 to 0.7502 (p = 0.003). Stratified analysis showed that the correlations did not hold true for subjects who were non-smoker or with histories of diabetes. None of the stratifying factors significantly altered the correlation (all p for interaction < 0.05).

Conclusions

We found a positive linear correlation between plasma TMAO and SYNTAX score among newly diagnosed CHD individuals in Chinese population.
Predictive value of preoperative CT enhancement rate and CT perfusion parameters in colorectal cancer
Authors: Li Ze-mao , Zhou Wei , Feng Li , Zhang Hui-ying , Chen Wei-bin
Published: May 2024

Background

Angiogenesis is a critical step in colorectal cancer growth, progression and metastasization. CT are routine imaging examinations for preoperative clinical evaluation in colorectal cancer patients. This study aimed to investigate the predictive value of preoperative CT enhancement rate (CER) and CT perfusion parameters on angiogenesis in colorectal cancer, as well as the association of preoperative CER and CT perfusion parameters with serum markers.

Methods

This retrospective analysis included 42 patients with colorectal adenocarcinoma. Median of microvessel density (MVD) as the cut-off value, it divided 42 patients into high-density group (MVD ≥ 35/field, n = 24) and low-density group (MVD < 35/field, n = 18), and 25 patients with benign colorectal lesions were collected as the control group. Statistical analysis of CER, CT perfusion parameters, serum markers were performed in all groups. Receiver operating curves (ROC) were plotted to evaluate the diagnostic efficacy of relevant CT perfusion parameters for tumor angiogenesis; Pearson correlation analysis explored potential association between CER, CT perfusion parameters and serum markers.

Results

CER, blood volume (BV), blood flow (BF), permeability surface (PS) and carbohydrate antigen 19 − 9 (CA19-9), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), trefoil factor 3 (TFF3), vascular endothelial growth factor (VEGF) in colorectal adenocarcinoma were significantly higher than those in the control group, the parameters in high-density group were significantly higher than those in the low-density group (P < 0.05); however, the time to peak (TTP) of patients in colorectal adenocarcinoma were significantly lower than those in the control group, and the high-density group showed a significantly lower level compared to the low-density group (P < 0.05). The combined parameters BF + TTP + PS and BV + BF + TTP + PS demonstrated the highest area under the curve (AUC), both at 0.991. Pearson correlation analysis showed that the serum levels of CA19-9, CA125, CEA, TFF3, and VEGF in patients showed positive correlations with CER, BV, BF, and PS (P < 0.05), while these indicators exhibited negative correlations with TTP (P < 0.05).

Conclusions

Some single and joint preoperative CT perfusion parameters can accurately predict tumor angiogenesis in colorectal adenocarcinoma. Preoperative CER and CT perfusion parameters have certain association with serum markers.
The prevalence and severity of upper gastrointestinal complications among patients with chronic diseases: a cross-sectional study from Palestine
Authors: Al Ramahi Rowa , Tumeh Deema
Published: May 2024

Background

Many old people have at least one chronic disease. As a result, multiple drugs should be used. Gastrointestinal complications may occur because of the harmful effects of these chronic drugs on the stomach. The study aimed to assess the prevalence of upper gastrointestinal complications in patients taking chronic medications, the severity of these symptoms, and whether they take any gastro-protective drugs or not.

Methodology

This was a cross-sectional study through face-to-face questionnaires from internal outpatient clinics at a specialized hospital. Patients with chronic diseases who were taking at least one chronic medication were included in the study. Data Collection Form was used to gather information. The Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) was used to evaluate the severity of the upper gastrointestinal symptoms. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) version 21.

Results

A total of 400 patients with chronic diseases and using multiple medications were included. Among them, 53.8% were females and 56% were married, 58.5% were unemployed, 70% were not smokers, the mean age was 54.7 ± 17.5 years. The most common comorbid diseases among the patients were diabetes, hypertension, and arthritis, with percentages of 44.3%, 38%, and 27.3%, respectively. The mean number of chronic medications used was 3.36 ± 1.6 with a range of 1 to 9. The most commonly used was aspirin with a percentage of 50%, followed by atorvastatin, bisoprolol, and insulin with percentages of 29.5%, 25%, and 20.3%, respectively. Among the 400 participants, 362 (90.5%) suffered from upper gastrointestinal side effects like indigestion (65.8%), heartburn (78.3%), nausea (48.8%), and regurgitation (52.0%). Based on SF-LDQ scoring, of the 400 respondents, 235(58.8%), 109(27.3%) and 18(4.5%) suffered from mild, moderate and severe dyspepsia, respectively. A high percentage 325 (81.3%) of participants were prescribed gastro-protective medications. Proton pump inhibitors were the most prescribed group in 209 (52.3%) patients. Dyspepsia was significantly associated with older age (p-value = 0.001), being educated (p-value = 0.031), not being single (p-value < 0.001), having health insurance (p-value = 0.021), being a smoker (p-value = 0.003), and using ≥ 5 medications (p-value < 0.001).

Conclusion

Upper gastrointestinal complications among patients with chronic diseases were very common. Fortunately, the symptoms were mild in most cases. The risk increased with age and using a higher number of medications. It is important to review patients’ medications and avoid overuse of them, in addition to use gastro-protective agents when needed.
Role of probiotic as adjuvant in treating various infections: a systematic review and meta-analysis
Authors: Nelwan Erni Juwita , Herdiman Allerma , Kalaij Ayers Gilberth Ivano , Lauditta Richella Khansa , Yusuf Syarif Maulana , Suarthana Eva
Published: May 2024

Background

Research on the advantages of probiotics has attracted increasing interest based on the number of publications, products, and public awareness of their benefits. This review evaluated the role of probiotics (single and multiple regimens) as an additional regimen to treat common infectious diseases, including Helicobacter. pylori, diarrheal infections, urinary tract infections (UTIs), upper respiratory tract infections (URTIs), and HIV infections.

Methods

We searched randomized controlled trials from PubMed, Scopus, Embase, and Cochrane and identified 6,950 studies. Duplicates were removed, and titles and abstracts were filtered. Bias was evaluated using the Cochrane Risk of Bias Tool for Randomized Trials (ROB 1.0 and 2.0). The certainty of the evidence was evaluated using GRADE. Data were extracted and meta-analysis was performed using RevMan.

Results

A total of 32 studies were included in this study (22 H. pylori studies, 2 diarrheal infection studies, 6 UTI studies, and 2 HIV infection studies). There was no study on URTI. Probiotics, in addition to primary treatment, could improve the eradication of H. pylori versus the control (RR: 1.09; 95% CI:1.04 − 1.13, p value = 0.001) and achieve a cure range of Nugent score in UTI patients (RR 1.38; 95% CI: 1.01 − 1.89, p value = 0.04). For eradicating H. pylori infection, subgroup analysis based on the therapy regimen showed that standard triple therapy was slightly superior compared to quadruple therapy in eradicating H. pylori (RR: 1.14 vs. 1.01, respectively). Single strain probiotics showed a similar effect to multiple strain probiotic regimens (both had an RR of 1.09). The effect estimates of the use of single strain probiotics as adjuvant therapy in eradicating H. pylori and the use of probiotics in UTI had a high certainty of evidence. Meta-analysis was not performed for infectious diarrheal because there were only two eligible studies with different probiotic supplementations and outcome parameters. Nonetheless, they showed that the diarrheal incidence was lower and complete remission of diarrheal was higher after the regimen of probiotics. Similarly, a meta-analysis was not performed for HIV infection because the two eligible studies used different designs and comparators with contradicting findings.

Conclusion

This meta-analysis showed beneficial use of single strain probiotics as adjuvant therapy in eradicating H. pylori and the use of probiotics in UTI. Probiotic supplementation might not be beneficial for patients given a quadruple therapy. Single-strain and multi-strain probiotic regimens had similar effects in increasing the eradication rate of H. pylori. Our study also suggested that the benefits of probiotics as an additional regimen in infectious diarrheal and HIV infections remain unclear; more studies are needed to confirm the benefits.
The relationship between perioperative serum albumin and contrast-induced acute kidney injury in patients after percutaneous coronary intervention
Authors: Wang Dong , Yan Gaoliang , Qiao Yong , Sun Renhua
Published: May 2024

Objective

Contrast-induced acute kidney injury (CI-AKI) is a common complication in patients undergoing percutaneous coronary intervention (PCI). Studies have shown that perioperative serum albumin levels may play a role in the occurrence of CI-AKI. In this study, we aimed to investigate the effect of perioperative serum albumin (delta albumin or &Alb) levels on the occurrence and long-term prognosis of CI-AKI patients after PCI.

Methods

A total of 959 patients who underwent PCI between January 2017 and January 2019 were selected for this study. A receiver operating characteristic curve was used to determine the optimal cut-off value of the &Alb level for predicting CI-AKI after PCI. Patients were divided into two groups based on the optimal cut-off value: the high &Alb group (&Alb ≥ 4.55 g/L) and the control group (&Alb < 4.55 g/L). The incidences of CI-AKI and major adverse cardiac events (MACEs, including all-cause death, nonfatal myocardial infarction, and target vessel revascularization) were compared between the groups. Cox regression analysis was used to identify predictors of long-term prognosis after PCI.

Results

Of the 959 patients, 147 (15.3%) developed CI-AKI after PCI. The CI-AKI group had a greater level of &Alb than did the non-CI-AKI group [(6.14 (3.90–9.10) versus 3.48 (4.31–6.57), P < 0.01)]. The incidence of CI-AKI in the high &Alb group was significantly greater than that in the low group (23.6% versus 8.3%, P < 0.01). After a 1-year follow-up, the incidence of MACEs was significantly greater in the high &Alb group than in the low group (18.6% versus 14.5%, P = 0.030). Cox regression analysis confirmed that CI-AKI was an independent predictor of MACEs at the 1-year follow-up (HR 1.43, 95% CI 1.04–1.96, P = 0.028). In addition, patients with low preoperative serum albumin levels had s significantly greater incidence of MACEs than did those with high preoperative serum albumin levels (23.2% versus 19.5%, P = 0.013).

Conclusion

In summary, high baseline &Alb levels are an independent risk factor for CI-AKI in patients after PCI. The occurrence of CI-AKI in the perioperative period is also an independent predictor of long-term prognosis after PCI. These findings highlight the importance of monitoring &Alb levels and taking steps to prevent CI-AKI in patients undergoing PCI.