bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct comparison of KATUSHKA far-red fluorescent protein variants with luciferase bioluminescence in xenograft mouse models of epithelial tumor studies
Authors: Levchuk K. A. , Bogdanova D. A. , Ershova A. , Smirnov S. V. , Goldaeva A. A. , Vasuytina M. L. , Istomina M. S. , Demidov O. N. , Petukhov A. V. , Toropova Ya. G.
Published: March 2023

Background. Research in oncology assumes establishment and usage of xenograft animal models, meeting the requirements of humanity and rationality. Although praised as promising field of research, preclinical studies of low-molecular-weight inhibitors, antitumor monoclonal antibodies, vaccines, cellular therapy products, CAR-T cells entail continuous control of tumor growth dynamics. Luciferase detection of bioluminescence requires injection of a reporter substrate. However, injections not only are laborious, time-consuming and expensive, but are also stressful for animals. Thus, a vast variety of new visualization methods is employed, including proteins of the far-red spectrum.

Objective. The study aimed to compare detection efficiency of tumor growth dynamics in mice models of cervical cancer, applying a commercially available line of fluorescent red protein derivatives of Katushka clade and Renilla luciferase, that is commonly used in in vivo studies.

Design and methods. Xenograft mice models were derived injecting modified HeLa cell line, that expresses fluorescent reporter proteins: Katushka, Katushka2S, TurboRFP, TurboFP650 and Renilla enzyme.

Results. Spectral properties and emission wavelength of far-red fluorescent protein Katushka and Katushka2S outlines these markers within RFP derivatives lineage as outstanding instrument for in vivo tumor visualization.

Conclusion. Detection of fluorescent far-red reporters Katushka and Katushka2S can be considered as a credible alternative to Renilla luciferase bioluminescence in experimental models in vivo on the part of immunotherapy research.
Radiologic imaging of sleep disorders in patients with acute ischemic stroke
Authors: Borshevetskaya A. A. , Trushina L. I. , Efimtsev A. Yu. , Ternovykh I. K. , Galyautdinova L. E. , Yerogova V. S. , Alekseeva T. M. , Trufanov G. E.
Published: March 2023

Sleep is an important and complex physiological process that is necessary for the normal functioning of any organism. Sleep disorders diagnostics is an issue of interest in patients with acute ischemic stroke management. Currently these disorders are considered not only as a consequence of earlier stroke but as an acute cerebrovascular disease risk factor itself. Sleep disorders in patients with acute cerebrovascular disease can be presented in different types, including: insomnia, sleep apnea, central disorders of hypersomnolence, circadian rhythm sleep-wake disorders, parasomnias, sleep related movement disorders, unspecified sleep related disorders.

There are very few publications on the subject of sleep disorders associated with acute ischemic stroke, despite the fact that imaging of each of these conditions separately occupies a significant place in radiology.

Polysomnography is considered to be the gold standard in sleep disorders diagnostics. Contrary to that, the precise imaging of acute cerebrovascular accidents requires high-technology modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI).

The article represents a current literature review regarding radiologic methods in diagnostics of sleep disorders in patients with acute ischemic stroke anamnesis.
Examination of Secondary School Mathematics Curriculum in Terms of 21st Century Skills
Authors: SARIGÖZ Okan
Published: March 2023

Abstract

The curriculum is the whole system that enables them to develop and renew their school education system. With the transition to the constructivism model in the schools of the world countries, many countries have revised their curricula according to this model. The mathematics curriculum taught in secondary education in Turkey was first revised by the Ministry of National Education in 2005 and then renewed in 2018. The aim of this research is to examine the secondary school mathematics curriculum in 2018 (achievements and activities) within the context of 21st century skills. Achievements and activities determined will be evaluated and examined in terms of learning and renewal skills. In line with this purpose, the research analyzed how much 21st century skills were included in the learning outcomes of the 2018 secondary school mathematics curriculum and its effects in the textbooks In addition, in the research, it was analyzed how much problem solving, critical thinking, creative thinking and communication skills of the P21 framework learning and innovation skills were included in the 2018 secondary school mathematics curriculum achievements and textbooks. The research model was conducted with document analysis, one of the qualitative research methods. In the document analysis, 21st century skills were selected by taking into account the P21 framework for 21st century skills. These skills are grouped in three areas: learning and innovation, information, media and technology, and life and professional skills. At the end of the research, it was determined that, due to the nature of the mathematics course, problem solving skills are included in almost all achievements and activities, while skills other than problem solving skills are not included in the achievements, these skills are included in the coursebook activities.

Keywords: 21st century skills, Secondary school mathematics curriculum, Mathematics curriculum, P21
Öğretmenlerin Örgütsel Adalet ve Örgütsel Muhalefet Algıları ile Otoriter Yönetim Tarzına İlişkin Algıları
Authors: GEDİK Aytaç , ÜSTÜNER Mehmet
Published: March 2023

Bu araştırmanın amacı okul müdürlerinin otoriter yönetim tarzı ile öğretmenlerin örgütsel adalet ve örgütsel muhalefet algıları arasındaki ilişkilerin incelenmesidir. Araştırmanın evreni 2020-2021 eğitim öğretim yılında Malatya ili merkez ilçeleri olan Battalgazi ve Yeşilyurt İlçe Milli Eğitim Müdürlüklerine bağlı okullarda görev yapmakta olan 8989 öğretmenden, örneklemi ise evrendeki okullardan kota örnekleme yöntemiyle belirlenen 535 öğretmenden oluşmaktadır. Araştırma nicel yöntemli olup, ilişkisel model ile desenlenmiştir. Araştırmada, öğretmenlerin, okul müdürlerinin otoriter yönetim tarzı, örgütsel adalet ve örgütsel muhalefet algıları ile ilgili alanyazın göz önünde bulundurularak doğrudan ve dolaylı etkileri öngören bir model öne sürülmüştür. Bu model yapısal eşitlik modellemesi (YEM) çerçevesinde gözlenen değişkenlerle path (yol) analizi ile test edilmiştir. Araştırma sonucunda, belirlenen 10 hipotezin 3’ünün reddedildiği, 7’sinin ise kabul edildiği görülmüştür. Araştırmanın öne çıkan bulgularına bakıldığında, okul müdürlerinin otoriter yönetim tarzının öğretmenlerin örgütsel adalet algılarının negatif yönde doğrudan anlamlı bir yordayıcısı olduğu belirlenmiştir. Okul müdürlerinin otoriter yönetim tarzının öğretmenlerin dikey muhalefet algılarının doğrudan anlamlı bir yordayıcısı olmadığı; ancak otoriter yönetim tarzının, öğretmenlerin yatay ve dışa aktarılmış muhalefet algılarını pozitif yönde ve anlamlı düzeyde yordadığı belirlenmiştir. Araştırma modelindeki aracılık etkileri incelendiğinde, örgütsel adaletin, okul müdürlerinin otoriter yönetim tarzı ile öğretmenlerin dikey muhalefet algısı ilişkisinde anlamlı bir aracı değişken olduğu sonucuna ulaşılmıştır. Ayrıca örgütsel adaletin, okul müdürlerinin otoriter yönetim tarzı ile öğretmenlerin yatay muhalefet algısı ilişkisinde de anlamlı bir aracı değişken olduğu tespit edilmiştir. Otoriter yönetim tarzına sahip okul müdürleri ile birlikte görev yapan öğretmenlerin dikey muhalefet stratejisinden kaçınarak yatay ve dışa aktarılmış muhalefete yöneldiği; ancak otoriter müdürün adil olması halinde dikey muhalefet stratejisini tercih edebileceği belirlenmiştir. Bu sonuçlar okullarda dikey muhalefetin gelişiminde örgütsel adaletin önemini ortaya koymaktadır. Bu bağlamda öğretmenlerin örgütsel adalet algılarını daha da geliştirebilmek amacıyla okul yönetiminde adalet, açıklık, tarafsızlık, tutarlılık, ortak çıkar, eşitlik, objektiflik ve şeffaflık ilkelerini içeren etik standartların belirlenmesi gerekmektedir.
Geomorfologia e padrões de empilhamento da barreira holocênica no Litoral Norte do Rio Grande do Sul
Authors: Zanchi Watanabe Débora Sayuri , Barboza Eduardo Guimarães , Rosa Maria Luiza Correa da Camara , Dillenburg Sérgio Rebello , Caron Felipe , Do Nascimento Ritter Matias , Bitencourt Volney Junior Borges de , Manzolli Rogério  Portantiolo
Published: March 2023

Barreiras costeiras podem exibir uma variedade de características estratigráficas e morfologias, refletindo os fatores condicionantes da sua formação e desenvolvimento atuantes em diferentes escalas temporais (secular e milenar) e espaciais, determinando padrões de empilhamento estratigráfico distintos. Neste trabalho, investiga-se a barreira holocênica no litoral norte do Rio Grande do Sul, entre o balneário de Dunas Altas e a cidade de Xangri-Lá, com o objetivo de analisar em detalhe a extensão e as características dos setores que apresentam padrões de empilhamentos estratigráficos progradacionais e retrogradacionais. Assim, perfis de Georadar (GPR) foram adquiridos perpendicularmente à linha de costa, ao longo de 65 km. Uma sondagem SPT foi realizada até 20,45 m de profundidade e a análise morfológica da barreira holocênica foi conduzida através de modelo digital de superfície (TanDEM-X). Definiram-se intercalações longitudinais no padrão de empilhamento estratigráfico da barreira. Dunas Altas apresenta um padrão de empilhamento estratigráfico progradacional. Em Quintão, 6,5 km ao norte, a barreira muda seu padrão de empilhamento estratigráfico para retrogradacional. Esse padrão se mantém até Tramandaí Sul, onde se altera para progradacional em um intervalo de 1 km, mantendo-se assim até Xangri-Lá. A delimitação dos padrões de empilhamento estratigráfico distintos possibilitou o entendimento do comportamento da barreira em uma escala de longo período, representando também uma importante contribuição à gestão costeira, principalmente no que diz respeito à delimitação de setores com comportamento erosivo.
Parameters optimization of electro-hydraulic power steering system based on multi-objective collaborative method
Authors: Cui Taowen , Wang Shuaiyin , Qu Yuan , Chen Xiang
Published: March 2023

Electro-hydraulic power steering (EHPS) systems are widely used in commercial vehicles due to their adjustable power assist and energy-saving advantages. In this paper, a dynamic model of the EHPS system is developed, and quantitative expressions for three evaluation indexes, steering road feel, steering sensibility and steering energy loss, are derived for the first time. A multi-objective collaborative optimization model of the EHPS system is then established, which consists of one total system and three parallel subsystems, based on collaborative optimization theory. Considering the coupled variables of each subsystem, the total system is optimized by a multi-objective algorithm, while the subsystems are optimized by a single-objective algorithm. The optimization results demonstrate that the average frequency domain energy of the steering road feel is increased by 69.1%, the average frequency domain energy of steering sensitivity is reduced by 19.2%, and steering energy consumption is reduced by 10.8% compared to the initial value. The non-dominated sorting genetic algorithm-II (NSGA-II) shows superior comprehensive performance compared to the other two multi-objective algorithms, and the optimization performance can be further improved by setting appropriate algorithm parameters.
Leaf removal and deficit irrigation have diverse outcomes on composition and gene expression during berry development of Vitis vinifera L. cultivar Xinomavro
Authors: Alatzas Anastasios , Theocharis Serafeim , Miliordos Dimitrios-Evangelos , Kotseridis Yorgos , Koundouras Stefanos , Hatzopoulos Polydefkis
Published: March 2023

The quality characteristics of a certain grapevine cultivar are determined by the combinatorial action of the genotype and environmental factors, such as soil, landscape and climate. Another critical parameter is the viticultural techniques utilised to improve grape berry quality. The influence of two viticultural practices, deficit irrigation and leaf removal, on the Greek Vitis vinifera L. cultivar ‘Xinomavro’ was investigated during the 2019 and 2020 vintages. Physiology measurements and berry sampling were performed at three phenological stages (green berry, veraison and harvest). The expression of specific genes known to control grape colour, aroma and flavour was studied in conjunction with berry growth and composition. All the parameters contributing to final yield, such as berry size, cluster weight and yield/vine, were reduced in non-irrigated and defoliated vines compared to their control (irrigated and non-defoliated) vines. Both treatments showed a significant increase in anthocyanin level, whereas total phenols increased in the deficit irrigation treatment only. Water deficit had no effect on total soluble solids, whereas leaf removal resulted in significantly increased levels compared to the controls. The expression profile of the genes examined was altered during ripening. Although both water deficit and defoliation positively influenced gene expression, there were several diverse responses among the phenological stages that depended on the vintage.
Agroecologia e Cultura Corporal: proposta ético-política da Educação Física na Educação do Campo
Authors: Silveira Leonardo Lemos , Frizzo Giovanni , Mota Carla Rosane , Silva Bruno Nicanor da , Goncalves Mayara Galvao
Published: March 2023

The objective of this text is to systematize an ethical-political proposal for Physical Education in Rural Education, as a subsidy for the organization of pedagogical work based on the experience we developed with the Technical Course in Agroecology, in an integrated way, at the Escola Família Agrícola da Região Sul in Rio Grande do Sul. This systematization is intended to accumulate elements to contribute to the pedagogical work of Physical Education based on the principles of Rural Education, Agroecology, Pedagogy of Alternation and Corporal Culture as a reference basis for the teaching and learning processes.
A new definition and three categories for classifying ecosystems
Authors: Gómez-Márquez Jaime
Published: March 2023

The ecosystem is an essential biological concept that links the living and the inanimate. Its study has become pivotal to the analysis of global changes and environmental impacts caused by human activities and population growth. The simplest definition of ecosystem refers to a specific community of organisms that interact with each other and with their environment. However, this definition says nothing about the open character of ecosystems, about the hierarchy among species and processes, or about their capacity to evolve as a whole throughout the history of life on this planet. Here, I first take a new look at the concept of ecosystem based on the elements that in my opinion characterize it, emphasizing the importance of viruses as components of biodiversity. Secondly, I propose three categories for the global categorization of ecosystems according to the degree of human intervention. Category 1 is any undisturbed natural ecosystem. Category 2 includes ecosystems altered by humans due to socioeconomic development and population growth, causing environmental degradation and biodiversity loss. Category 3 covers all ecosystems that have been altered by the introduction of synthetic or modified organisms generated in the laboratory, the consequences of which are much more difficult to predict. Knowledge of the global distribution of these categories would help to plan global environmental policies that would contribute to making the development of our society compatible with the preservation of biodiversity
Damage symptoms, development, and reproductive performance of the fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) on fodder maize and cob
Authors: Mohamed Hend O. , Dahi Hassan F. , Awad Azza A. , Gamil Walaa E. , Fahmy Bassam F.
Published: March 2023

In recent years, the biggest threat to maize production has been the invasion of a new exotic pest, the fall armyworm (FAW), Spodoptera frugiperda (Lepidoptera: Noctuidae). Therefore, in this study, the damage characteristics, the development, and the reproductive preferences of this pest were evaluated when its larvae were fed on fodder maize and corn cobs. In this context, the weights (g) of larvae, pupae, and adults, pupal period (days), sex ratio (%), longevity (days), oviposition preferences, fecundity (%), egg incubation period (days), and hatchability (%) on fodder maize and corn cobs were assessed. The results exhibited that the FAW larvae were able to feed on and infest both fodder maize and corn cobs, causing significant damage particularly to the cobs making them unsuitable for marketing and human consumption. Moreover, the larvae and pupae from the corn cobs had the greatest weight and were significantly affected by food items. However, the pupal period was shorter in the corn cobs (7.76 days). Regardless of the type of larval feeding, the emergence of females (>62%) was more than that of males. On the contrary, the longevity of adults from larvae fed on fodder maize (7 days) was shorter than that of larvae fed on corn cobs. Feeding larvae on fodder maize or cobs did not significantly influence the reproductive performance of females (pre-oviposition, oviposition, post-oviposition periods, fecundity, and egg hatching rate). However, the larval diet greatly affected the egg hatching which was prolonged when the diet was based on corn cobs. The results of this study could play a significant role in predicting the damage and reproductive performance of FAW in maize fields during their developmental growth, which will further help in developing effective integrated management techniques against this pest.
Scripted communication between a human and a robot
Authors: Kartashev Vladimir Alekseevich , Kartashev Vsevolod Vladimirovich
Published: March 2023

Currently the technology providing the means both of arbitrary and scripted verbal communication between a person and a robot has become widespread. Usually in this communication, a person does not observe the appearance of the robot, which creates uncomfortable conditions for a human to conduct a dialogue. In the described hardware and software, a person exchanges phrases with a robot and watches its animated image on the display screen. Experiments have shown that even fairly simple animation tools make it possible to make a communication much more natural compared to the one comprising the demonstration of a static image of a robot.
Hubungan Dukungan Sosial dengan Tingkat Depresi Pasien Systemic Lupus Erythematosus (SLE)
Authors: Naziha Aliya , Maharatih Gusti Ayu , Bulan Kakanita Hermasari
Published: March 2023

Pendahuluan: Systemic Lupus Erythematosus (SLE) adalah penyakit autoimun yang disebabkan oleh pengendapan kompleks imun dengan keterlibatan berbagai organ. Salah satu manifestasi yang paling umum SLE adalah Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). Manifestasi klinis NPSLE yang paling banyak ditemukan adalah gangguan mood yaitu depresi. Kondisi pasien SLE yang mengalami berbagai perubahan secara fisik dapat mempengaruhi keadaan psikologisnya sehingga dibutuhkan dukungan sosial yang positif karena dapat menjadi penyangga efek negatif dari rasa sakit dan depresi. Penelitian ini bertujuan untuk mengetahui hubungan dukungan sosial dengan tingkat depresi pada penderita Systemic Lupus Erythematosus (SLE) di Yayasan Tittari Surakarta.
Metode: Penelitian ini bersifat observasional analitik dengan pendekatan cross-sectional. Subjek penelitian adalah penderita Systemic Lupus Erythematosus (SLE) di Yayasan Tittari Surakarta. Pengambilan sampel dilakukan dengan teknik purposive sampling dengan pengisian kuesioner sosiodemografi, The Social Provisions Scale (SPS), dan Hospital Anxiety and Depression Scale – Depression (HADS-D). Analisis data dilakukan dengan uji normalitas Kolmogorov–Smirnov, serta uji bivariat menggunakan Spearman Rank.
Hasil: Penelitian ini diikuti oleh 60 responden. Responden didominasi oleh perempuan (96,7%), dengan rentang usia terbanyak adalah 18 – 35 tahun (48,3%), sudah menikah (78,3%), serta memiliki tingkat pendidikan perguruan tinggi (71,7%). Mayoritas responden telah menderita SLE ≥2 tahun (95%) serta mengonsumsi obat steroid dan immunosupressan (41,7%). 35 responden memiliki dukungan sosial rendah (58,3%) sedangkan 25 responden memiliki dukungan sosial tinggi (41,7%). Berdasarkan tingkat depresi, 49 responden (81,7%) dalam keadaan normal (81,7%), 9 responden memiliki depresi ringan (15%), 2 responden mempunyai depresi sedang (3,3%), dan tidak ada responden yang memiliki depresi berat. Hubungan dukungan sosial dengan tingkat depresi pada pasien SLE di Yayasan Tittari Surakarta menunjukkan nilai p = 0,004 (p<0,05) dan nilai koefisien korelasi r= 0,370.
Kesimpulan: Terdapat korelasi lemah antara dukungan sosial dengan tingkat depresi pada pasien Systemic Lupus Erythematosus (SLE) di Yayasan Tittari Surakarta dengan arah korelasi negatif.
Deskripsi Korban Mati Akibat Jejas di Leher Yang Diperiksa di RSUD Dr. Moewardi Tahun 2015-2021
Authors: Novianto Adi Nugroho  , Haniifah Firda Luthfiyyatul , Suwandono Adji
Published: March 2023

Introduction: Surakarta has a population growth rate 0.43%, the high population density can cause population problems homicides, accidents, and hanging themselves. This case can be proven by the discovery of neck injuries due to strangulation. This study was conducted to find out about the description of victims who died due to neck injuries in 2015-2021.

Methods: This study used a descriptive observational method from Visum et Repertum with the population in the form of all forensic pathology case due to neck injuries which were examined at Dr. Moewardi hospital in 2015-2021. The sampling technique in this study was purposive sampling that met the inclusion and exclusion criteria.

Results: From the VeR Dr. Moewardi hospital in 2015-2021 obtained as many as 28 cases of forensic pathology due to neck injuries with the description: (1) tilted injury shape 57.14%, horizontal 39.29%, crescent moon 3.57%; (2) blunt hardness 96.43%, sharp 3.57%; (3) submission of requests for VeR from the Surakarta Police 53.57%, Sukoharjo 14.29%, Boyolali 14.29%, Wonogiri 7.14%,  Sragen 7.14%, Karanganyar 3.57%; (4) external examination 57.14%, autopsy 42.86%; (5) suicide 53.57%, homicide 32.14%, accident 7.14%; (6) age <15 years 7.14%, 15-64 years 78.57%, >64 years 10.71%; (7) male 67.86%, female 32.14%; (8) private employment 67.86%, students 10.71%, housewives 7.14%, not working 7.14%

Conclusion: From this research, the most results were in the form of slanted neck injuries, violence due to blunt objects, requests for VeR from the Surakarta police, external examination, the method of death was suicide, victims of productive age, men, and private workers.
Hubungan Jarak dan Durasi Penggunaan Smartphone dengan Digital Eye Strain pada Anak Sekolah Menengah Pertama di Masa Pandemi COVID-19
Authors: Putri Yumna Nur Aqila  , Hari Wahyu Nugroho  , Fadhilah Tia Nur
Published: March 2023

Pendahuluan: Selama pandemi COVID-19, pemerintah mengeluarkan kebijakan physical distancing, sehingga membuat anak-anak menggunakan smartphone sebagai media belajar maupun hiburan dan anak-anak memilih menghabiskan waktu pada smartphone, sehingga berdampak pada kesehatan mata, salah satunya dapat menimbulkan digital eye strain atau mata lelah. Beberapa penelitian yang telah dilakukan cenderung mengambil sampel orang dewasa dan ini menjadikan penelitian digital eye strain pada anak perlu dilakukan. Penelitian ini bertujuan menganalisis hubungan jarak dan durasi penggunaan terhadap digital eye strain, serta faktor resikonya
Metode: Penelitian cross sectional dilakukan dengan mengambil sampel siswa/I kelas VII, VII, dan IX SMP Al Azhar Syifa Budi, Surakarta dan didaptakan jumlah sampel 99 orang yang memenuhi kriteria inklusi dan eksklusi. Penelitian ini memilih jarak dan durasi penggunaan smartphone sebagai variabel bebas dan digital eye strain sebagai variabel terikat. Pengukuran digital eye strain menggunakan Computer Vision Syndrome Questionnaire (CVS-Q). Analisis data menggunakan uji hipotesis bivariat dengan SPSS.
Hasil: Pada hasil penelitian didapatkan hubungan yang signifikan yaitu p=0,002 pada jarak penggunaan smartphone dengan Digital Eye Strain. Pada durasi penggunaan smartphone dengan Digital Eye Strain menunjukkan korelasi yang signifikan dengan p=0,022
Kesimpulan: Menggunakan smartphone dengan jarak yang dekat dan durasi yang lama dapat beresiko mengalami Digital Eye Strain
Efek Ekstrak Etanolik Daun Kelor Terhadap Kadar HDL, Kadar LDL, serta Ketebalan Aorta Tikus Wistar Model Sindrom Metabolik
Authors: Nadhira Aulia Ninggar , Nurwati Ida , Budiani Dyah Ratna
Published: March 2023

Pendahuluan: Daun kelor diketahui memiliki potensi menurunkan gejala sindrom metabolik. Kriteria sindrom metabolik antara lain yait terdapat penurunan HDL, peningkatan LDL, dan penebalan dinding aorta. Tujuan penelitian ini adalah mengetahui pengaruh pemberian ekstrak etanolik daun kelor terhadap kadar HDL, kadar LDL, dan ketebalan aorta tikus wistar jantan model sindrom metabolik.
Metode: Penelitian bersifat eksperimental laboratorik menggunakan lima kelompok, yaitu KKN diberi pakan standar; KKP, KP1, KP2, dan KP3 diberi pakan tinggi lemak selama 28 hari dan injeksi STZ-NA pada hari ke-25. Kelompok perlakuan (KP) diberikan dosis ekstrak etanolik daun kelor masing-masing 150; 250; dan 350 mg/kgBB/hari. Kadar HDL dan LDL diukur pada hari ke-0, 25, 28, dan 57. Terminasi pada hari ke-57, aorta pars thoracica diberi pengecatan HE. Kadar HDL dan LDL dianalisis menggunakan paired t-test. Kadar HDL, LDL, dan ketebalan aorta dianalisis menggunakan one-way ANOVA dilanjutkan post hoc Tukey HSD. 
Hasil: Hasil paired t-test terdapat perbedaan bermakna antara kadar HDL dan LDL sebelum dan setelah pemberian ekstrak. Hasil one-way ANOVA dan post hoc Tukey HSD, kadar HDL dan LDL terdapat perbedaan bermakna antar kelompok sedangkan ketebalan aorta tidak terdapat perbedaan bermakna antar kelompok.
Kesimpulan: Ekstrak etanolik daun kelor dosis 150; 250; dan 350 mg/kgBB/hari dapat meningkatkan kadar HDL dan menurunkan kadar LDL, tetapi tidak berpengaruh terhadap ketebalan aorta tikus wistar jantan model sindrom metabolik.
Hubungan Gaya Hidup Hedonis Dengan Tingkat Stres pada Mahasiswi Kedokteran
Authors: Albert Yohanes Axel Yoagnesto  , Mohammad Fanani  , Lukman Aryoseto
Published: March 2023

Pendahuluan: Perkembangan jaman menyebabkan perubahan kebiasaan dan gaya hidup terutama pada mahasiswi salah satunya adalah gaya hidup hedonisme. Mahasiswi yang mengikuti gaya hidup hedonis memerlukan uang yang banyak untuk mencukupi keinginannya, hal ini dapat menyebabkan pengeluaran mahasiswi lebih banyak padahal mahasiswi mayoritas belum bekerja. Tidak dapat mengikuti gaya hidup hedonis dapat memicu rasa takut dan tertekan yang jika dibiarkan dapat menyebabkan stres. Tujuan dari penelitian ini untuk menilai hubungan antara gaya hidup hedonis dan tingkat stress mahasiswi.  
Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan studi cross sectional yang dilaksanakan di Program Studi Kedokteran Fakultas Kedokteran Universitas Sebelas Maret Surakarta. Sampel dari penelitian ini adalah 215 mahasiswi yang termasuk kedalam kriteria inklusi. Sampel diambil dengan teknik probability sampling jenis simple random sampling. Variable terikat adalah tingkat stress dan variable bebas adalah hedonism. Data gaya hidup hedonism diperoleh dari pengisian kuisioner skala gaya hidup hedonis dan data tingkat stress diperoleh dari pengisian kuisioner PSS-10 (Perceived Stres Scale). Data kemudian akan dihitung menggunakan software SPSS dan dianalisis menggunakan uji korelasi Spearman.
Hasil: Tidak terdapat hubungan yang signifikan antara hedonism dengan tingkat stress dengan kekuatan korelasi yang rendah dan arah negative antara gaya hidup hedonisme dengan tingkat stress pada mahasiswi di Program Studi Kedokteran Fakultas Kedokteran Universitas Sebelas Maret Surakarta.
Kesimpulan : Tidak terdapat hubungan antara gaya hidup hedonisme dengan tingkat stress pada mahasiswi di Program Studi Kedokteran Fakultas Kedokteran Universitas Sebelas Maret Surakarta.
Strategy For Collection and Distribution of Infaq Shodaqoh Zakat Funds At Amil Zakat Institution (LAZ) Sahabat Mustahiq Malang Branch
Authors: Nabilah Diananda Hanan , Hakim Rahmad , Hakim Arif Luqman , Fanani Ahmad
Published: March 2023

The strategy for collecting and distributing zakat, infaq, and shodaqoh funds is important andimplemented properly. Especially in areas such as Malang Raya which has the highest numberof muzakki in East Java. The purpose of this study is to conduct an in-depth analysis of thestrategy for collecting and distributing zakat, infaq, and shodaqoh funds (ZIS) at the Amil ZakatInstitute (LAZ) Sahabat Mustahiq Malang. This research is a qualitative research with a casestudy approach. Data collection techniques in this study were observation, interviews, anddocumentation. Data analysis techniques used in this study are data collection, datacondensation, data presentation, and drawing conclusions. The results of the study indicatethat there are two kinds of strategies in raising funds, namely direct and indirect. Direct is astrategy that is carried out directly between amil zakat institutions and muzakki or donors.Direct activities in the form of direct mail via whatsapp, direct meetings with potential muzakki,zakat outlets and portfolios. The indirect strategy is a strategy that is carried out indirectlybetween amil zakat institutions and muzakki or donors. Indirect activities are in the form ofcollaborating with other LAZ institutions, agencies or institutions, activating social media,magazines, websites, digital platforms and through Friends of Inspirational Action (SAINS)volunteers. In the strategy for distributing zakat, infaq, shodaqoh funds at LAZ SahabatMustahiq Malang, there is a pattern of distribution of zakat infaq shodaqoh funds, namelytraditional consumptive, creative consumptive, traditional productive, creative productive butin the distribution of infaq and shodaqoh zakat funds to 8 asnaf that have been listed in theQur'an 'an, LAZ Sahabat Mustahiq Malang prioritizes fakir, poor, zakat manager, sabilillahand ibn sabil only.
Accountability Analysis With The Application Of Psak 112 In The Financial Statements Of Cash Waqf In Madura
Authors: Wilantini Cici’ , Handayani Sri , Abidin Zainal
Published: March 2023

The importance of accountability financial reports is a form of accountability from waqf assetsentrusted by the wakif to an institution/agency that became nadzhir. The better the financialreports are made, the more trust will increase from the public and vice versa. PSAK 112regarding waqf accounting can help nadzhir parties to prepare better financial reports of waqfassets. This research uses a qualitative descriptive type approach. The research locations areLAZISMU Pamekasan and KSPPS Nuri East Java. Sources of data in the form of observations,interviews and documentation. The results of the research are; Accountability from LAZISMUPamekasan and KSPPS Nuri East Java has worked in accordance with the indicators andforming factors of financial report accountability. The application of PSAK 112 at LAZISMUPamekasan has a conformity of 35% and the remaining 65% still needs to be improved.Whereas in KSPPS Nuri East Java it has a suitability of 41% and the remaining 59% still needsto be fixed again. This means that the financial statements of cash waqf funds issued byLAZISMU Pamekasan and KSPPS Nuri East Java are still lacking from the financialcomponents commonly made by waqf institutions according to PSAK 112. At LAZISMUPamekasan and KSPPS Nuri East Java there has been no instruction from the leadership touse PSAK 112 and there is no concrete socialization from the authorities.
Public Attitudes and Awareness of Services Labeled as Halal
Authors: Syahriani Novita , Khamal Rokan Mustapa
Published: March 2023

This research was conducted to find out impact of people's attitudes and awareness on the halal label. Research method used in this study is quantitative research combined with narrative research, where this study aims to determine the correlation between attitudes, consumer enlightenment, and halal label. Result can be used as a result of hypothesis testing data, the Standardized coefficient value in the table is -.034 with a significant value indicating that the behavioral variable (X1) does not have a significant effect on the halal label (Y). Therefore, hypothesis 4 suspects that the attitude has a positive effect on the halal label is not supported. using the results of hypothesis testing data, the Standardized coefficient value in the table is .663 with a significant value sharing that the citizen awareness variable (X2) has a significant influence on the halal label (Y), in which the assumption of public awareness has a positive effect on the halal label is supported. Hypothesis 1 which has an attitude variable is not supported, therefore it does not have a positive effect on the halal label. Hypothesis 2 is supported, due to the assumption that citizen awareness has a significant/influence on the halal label.
Evidence of Moderation Maqashid Sharia : Financial Performance, Islamic Social Reporting and The Value of the Company
Authors: Rismayanti Dwi , Aisyah Esy Nur
Published: March 2023

Firm value influences investor perceptions to support the company's sustainability. The studyaimed to analyze the effect of financial performance and islamic social reporting on firm valueand the role of the maqashid sharia index in moderating financial performance and islamicsocial reporting on the company value of Islamic Commercial Banks in Indonesia. Theresearch method used is quantitative. The sampling technique used purposive sampling with asample of 6 Islamic Commercial Banks registered with the Financial Services Authority for2017-2021. The data analysis method used in this study is SEM-PLS with the SmartPLS version4.0.8.7 application. The results showed that the variables of financial performance and islamicsocial reporting had a significant effect on firm value. Then, the maqashid sharia index as amoderator variable cannot moderate the relationship between financial performance andislamic social reporting on firm value. Thus, the Maqashid sharia index is a moderatorpredictor because it can only independently influence the dependent variable.
The Growth Progression in Linear Body Measures among the Jeunkuruba, Kadukuruba and Yerava Tribal Boys of Karnataka
Authors:   Assistant Professor, Department of Anthropology, Karnataka State Open University, Muktha Gangothri, Mysore 570006, Karnataka, India., Keshava S.
Published: March 2023

The present study has been carried out to analyze population-wise growth progression in linear body measures among the Jenukuruba, Kadukuruba, and Yerava (boys aged 10- 16 years) Scheduled tribes of Karnataka. A total of 475 subjects were measured cross-sectionally for 12 linear body measurements following the standard measurement techniques. Analysis results of the present study exhibit the prevalence of Cephalo-Caudal and Caudo-Cephalic sequence of maturation within the components of extremities among Jenukuruba and Kadukuruba boys, but in the case of Yerava boys shows only Cephalo-Caudal sequence of maturation throughout the age range studied. When taking account of within the subsegments of the upper extremities Jenukuruba boys at all ages show only CaudoCephalic sequence of maturation, where as Kadukuruba boys show Caudo-Cephalic as well as mixed gradients of maturational sequence, but in case of Yerava boys shows Cephalo-Caudal sequence besides mixed gradients of maturational sequence. And in the sub-segments of the lower extremities, Jenukuruba shows Caudo-Cephalic the sequence of growth, where as among Kadukuruba and Yerava exhibit Caudo-Cephalic as well as mixed gradients of maturational sequence throughout the age range studied.
Archaeological Investigations in Baihar Tehsil of District Balaghat, Madhya Pradesh
Authors:   Research Scholar,Department of Ancient Indian History, Culture and Archaeology, Indira Gandhi National Tribal University, Amarkanatk, Madhya Pradesh 484887, India., Pandro Pankaj , Shrotriya Alok ,   Professor,Culture and Archaeology, Indira Gandhi National Tribal University, Amarkanatk, Madhya Pradesh 484887, India.
Published: March 2023

The district Balaghat of Madhya Pradesh comprises eleven Tehsils viz; Blight, Bihar, Brisa, Paraswada, Katangi, Waraseoni, Lalbarra, Khairlanji, Lanji, Kirnapur, and Tirodi. Various sites and monuments of the Bihar Tehsil were covered during the archaeological exploration. This paper presents the results of archaeological investigations carried out in the Baihar Tehsil of Balaghat District. Variegated material has been noticed and analysed in the present study to gain insight of the past culture. Besides some known archaeological sites, exploration brought to light a series of new ancient sites. Sites, monuments and art-relics of Baihardivulge the religious, social, artistic and different customary practices of ancient period.
Socio-Cultural Lifestyle of Tri-Natives: Gond, Bhil and Santhal
Authors:   Assistant Archaeologist, Archaeological Survey of India, Agra, Kumar Om Prakash , Soni Amit ,   Associate Professor, Department of Museology, Faculty of Tribal Studies, Indira Gandhi National Tribal University, Amarkantak Madhya Pradesh-484886.
Published: March 2023

Tribal lifestyle is deeply associated with their culture, art and craft. A larger mass of tribal people live in rural areas. In central India, the area of Vindhya, Satpuda and Aravali Mountain ranges, starching from east to west in the states of West Bengal, Orissa, Jharkhand, Telangana, Chhattisgarh, Madhya Pradesh, Maharashtra, Gujarat and Rajasthan form a big tribal belt. Gond, Bhil and Santhal are the three biggest tribal communities residing in this central tribal region of India. These three dominating groups are comparatively developed then other tribal groups of the area, though their overall economy is still based on agriculture and labor work resulting in economic backwardness. But, new generation is gradually, getting educated and exposed to salaried jobs and modern technology. Due to better communication, exposure, marketization and modernization their culture is changing with time and need. Though, they have strong bond with their indigenous culture, religion and art, which has kept their tradition and lifestyle intact with relevant changes. But, changing lifestyle and economy has affected their art and craft. Themes, raw material and technology are changing their forms, symbols and patterns. Paintings have shifted from walls to canvas and taken professional shape. Festive and regular enjoyment with dance and music had developed as stage performance. But, they have not at all lost touch with their roots and cultural awareness is again revitalizing their bond with traditional dance, music and other art and craft forms. Celebrations are still celebrated with tribal songs and dances within the village's open courtyard. There are also several cultural and culinary habits, languages, social structures inclusive of marriage, and varieties of consciousness.
Frecuencia de terceros molares retenidos con relación al biotipo facial. Un estudio transversal.
Authors:   , Zeta Rodriguez Taylor Augusto
Published: March 2023

Objetivo: Identificar la frecuencia de terceros molares retenidos con relación al biotipo facial utilizando estudios 2D (panorámicos y cefalométricos) de pacientes que acudieron al centro de imágenes ZETA-EXMED en el periodo noviembre del 2018 a diciembre del 2021, en la ciudad de Lima, Perú. Metodología: el tipo de estudio de esta investigación es observacional, descriptivo, transversal y retrospectivo. Se evaluaron 6000 casos, cada uno compuesto de una imagen radiográfica panorámica y una cefalométrica, ambas tomadas al paciente en la misma fecha, de las cuales solo fueron incluidos en la investigación un total de 150 casos, por cumplir con los criterios de selección. Las mediciones se realizaron por un investigador entrenado y calibrado, utilizando el software Nemoceph para los trazados cefalométricos. Se utilizó para el análisis estadístico el programa SPSS versión 1.0.0.1401 (SPSS Inc., EE. UU.) y la prueba Chi cuadrado (p<0.05). Resultados: De los 150 casos revisados, 91 correspondieron al sexo femenino (60.66%) y 59 al sexo masculino (39.33%), dando como resultado que el biotipo dólicofacial se presentó con mayor frecuencia en estos, con un total de 27 casos (45.80%), mientras que, en mujeres, el biotipo braquifacial fue el de mayor frecuencia, con un total de 35 casos (38.50%). Así mismo, del total de terceros morales retenidos evaluados (403 piezas), 141 se presentaron en casos con biotipo dólicofacial, seguido del biotipo mesofacial con 139 piezas y finalmente el biotipo braquifacial con 123 piezas. Respecto a la evaluación de los terceros molares retenidos en relación con su posición y biotipo facial, se encontró 63 3MR en posición mesioangular y 28 en posición distoangular en dólicofacial, seguido de 48 piezas en posición vertical en braquifacial. Conclusiones: No existe una relación significativa entre la cantidad de terceros molares retenidos y su posición, en relación con el biotipo facial...
Dieta de la raya Rostroraja velezi (Rajiformes: Rajidae) frente al departamento de Piura Perú)
Authors:   , Molina Salgado Pamela Sofia
Published: March 2023

Dentro de los vertebrados, los batoideos son uno de los grupos menos estudiados y uno de los más vulnerables a la pesquería. La raya bruja Rostroraja velezi es un depredador en hábitats demersales. En el Perú, éste batoideo es capturado incidentalmente y no existen estudios sobre su ecología, incluyendo su dieta. El objetivo del estudio es determinar la dieta de R. velezi en el norte del Perú a través del análisis de contenido estomacal. Las muestras fueron colectadas en el muelle de Los Órganos (región Piura), entre 2016 al 2019. Sus capturas provienen de la pesca incidental de la pesquería artesanal de la merluza peruana (Merluccius gayi peruanus). Un total de 74 estómagos fueron colectados, de los cuales 59 presentaron contenido estomacal. Las rayas midieron entre 47.6 y 81.9 cm de longitud total (34.5-83.5 cm de ancho del disco). La curva acumulativa de presas mostró una tendencia asintótica para ambos niveles taxonómicos (< 0.1), y una confiabilidad en el número de muestras colectadas. La dieta comprendió 8 niveles taxonómicos, de los cuales dominaron Acanthephyra sp. (31% PSIRI), decápodos no identificados (15% PSIRI) y teleósteos no identificados (17% PSIRI). Se determinó una baja diferencia significativa en la dieta entre sexos (R= 0.21; p-valor <0.01). Además la posición trófica fue de 3.9 ± 0.7. Conclusión: R. velezi presenta un comportamiento alimenticio bentopelágico y es considerado predominantemente un depredador secundario en el norte del Perú. Este estudio representa el segundo reporte sobre dieta de R. velezi para el Pacífico sudeste y el primero para Perú. Por lo que representa una línea base para futuras investigaciones de dieta en la familia Rajidae en esta zona del Pacífico Sudeste.
Lessons from High-Speed Data Acquisition on Frac Plug Milling Operations
Authors: Newman Ken , Kelleher Patrick
Published: March 2023

Previous work has shown that large force waves traveling through the coiled tubing (CT) correlated with extended reach tool (ERT) operations can generate axial vibration harmonics in the CT that may lead to CT failures. This paper documents continued work which has shown that the surface equipment also has natural frequencies of vibration. When these natural frequencies are multiples of the ERT frequency, the ERT stimulates the surface equipment vibration modes.
Estimation of the Content of Stone Fine Powder in High-Performance Lightweight Rice Husk Concrete Blocks
Authors: Winarno Setya , Suharyatmo  , Arifudin Anggit Mas
Published: March 2023

Stone fine powder (SFP) is a solid by-product of the stone-cutting industry, which causes land and air pollution in the surrounding areas. In this study, SFP was used as a raw material in the manufacturing of lightweight material of SFP-based rice husk concrete blocks (RHCBs), and its optimal content to meet the performance of Indonesian standards was determined. The RHCBs studied here were composed of three materials: cement (binder), SFP, and raw rice husk (RRH). Samples were grouped into three batches: Batch-I, Batch-II, and Batch-III with binder-RRH ratios of 1:2, 1:3, and 1:4 respectively. Moreover, six binder-SFP ratios were tested in each batch, i.e., 1:0.25, 1:0.50 1:0.75, 1:1, 1:1.25, and 1:1.50. Thus, 18 mixes were cast to assess the performance of the SFP-based RHCBs. The results revealed that the increase of the SFP content in concrete mixture significantly enhances the density and compressive strength of SFP-based RHCBs, due to their denser structure. The SiO2 as the majority component of SFP does not have an impact on improving RHCB strength because it is chemically inactive. SFP-based RHCB with 300% RRH and the ratio of SFP to binder = 92.82–105.49% is the optimal choice. For practical purposes, it can be regarded as 100% SFP. This synergetic application of binder:SFP:RRH = 1:1:3 in a concrete mixture will generate the best SFP-based RHCB, with a density of around 1,345.22 kg/m3 and a compressive strength of approximately 2.80 MPa.
Effect of health and reproductive disorders on milk yield and fertility in dairy cows
Authors: Oresnik A.
Published: March 2023

Milk production, fertility and reproductive disorders were studied during 1153 lactations in Friesian cows on 5 Slovenian dairy farms. The average milk yield was 5631 ± 1775 kg/year. Mastitis was diagnosed in 42.1, lameness in 15.1, metritis in 23.9 and retained placenta in 16.1% of lactations. These 4 disorders represented 86.7% of all pathological findings in the herds. A significant influence of farm, lactation number and diseases on milk yield was found. Ketosis and parturient paresis was associated with higher milk yields and mastitis, retained placenta and abortion with lower milk yield. Fertility was negatively influenced by all diseases.
Characterization of an outbreak of anthrax in animals in North Dakota
Authors: Mongoh Mafany Ndiva , Dyer Neil W. , Stoltenow Charles L. , Khaitsa Margaret L.
Published: March 2023

The objective of this study was to characterize an outbreak of anthrax among animals in North Dakota in 2005, and determine characteristics and clinical signs associated with the disease. A total of 243 animals (183 cattle, 32 bison, 11 horses, 11 elk, five sheep and one deer) were diagnosed with anthrax at the Veterinary Diagnostic Laboratory at North Dakota State University, Fargo. Anthrax cases were defined as animals with typical clinical signs and positive results of laboratory culture and polymerase chain reaction (PCR) methods. Data for the study were obtained from veterinary laboratory records and questionnaires mailed to producers of affected animals. Anthrax occurred from July 1 to October 12 of 2005. The cases were located in 16 of 53 counties, specifically in eastern North Dakota, with Ransom, Lamoure and Barnes counties reporting most (71%) of the cases. The number of animals affected per premise varied from one to 40. The first cases were reported in bison. Males from all species infected had a higher attack rate (18/1000) than females (3/1000) with a gender ratio of 6:1, respectively. The predominant clinical signs in all cases were sudden death (38%) and bleeding from orifices (17%). Only 11 producers reported having vaccinated animals before the outbreak. Penicillin and tetracycline antibiotics were administered to animals during the outbreak. Forty producers (37%) burned and buried carcasses using commercial disposal services. Sixty-eight producers (63%) disposed of carcasses themselves by either burial only (11%), burned only (4.6%), or burned and buried (84.4%). Animals affected, clinical signs and final outcome were consistent with a natural anthrax outbreak.