bluuebunny/crossref_metadata_2025 huggingface dataset:
Yttrium Copper Titanate as a Highly Efficient Electrocatalyst for Oxygen Reduction Reaction in Fuel Cells, Synthesized via Ultrafast Automatic Flame Technique
Authors: Singh Laxman , Azad Uday Pratap , Singh Satendra Pal , Ganesan Vellaichamy , Rai U. S. , Lee Youngil
Published: August 2017

Replacing platinum (Pt) metal-based electrocatalysts used in the oxygen reduction reaction (ORR) in fuel cells is an important research topic due to the high cost and scarcity of Pt, which have restricted the commercialization of these clean-energy technologies. The ABO3-type perovskite family of an ACu3Ti4O12 (A = Ca, Y, Bi, and La) polycrystalline material can serve as an alternative electrocatalyst for the ORR in terms of low-cost, activity, and stability. These perovskite materials may be considered the next generation electro-catalyst for the ORR because of their photocatalytic activity and physical and chemical properties capable of containing a wide range of A- and B-site metals. This paper reports the ORR activity of a new Y2/3Cu3Ti4O12 perovskite, synthesized via a rapid and facile automatic flame synthesis technique using rotating disk electrode (RDE) measurements. Y2/3Cu3Ti4O12/C has superior ORR activity, stability, and durability compared to commercial Pt/C. The results presented in this article will provide the future perspectives to research based on ACu3Ti4O12 (A = Ca, Y, Bi, Sm, Cd, and La) perovskite as the next generation electro-catalyst for the ORR in various electrochemical devices, such as fuel cells, metal–air batteries, and electrolysis.
A Systematic Protein Refolding Screen Method using the DGR Approach Reveals that Time and Secondary TSA are Essential Variables
Authors: Wang Yuanze , van Oosterwijk Niels , Ali Ameena M. , Adawy Alaa , Anindya Atsarina L. , Dömling Alexander S. S. , Groves Matthew R.
Published: August 2017

Refolding of proteins derived from inclusion bodies is very promising as it can provide a reliable source of target proteins of high purity. However, inclusion body-based protein production is often limited by the lack of techniques for the detection of correctly refolded protein. Thus, the selection of the refolding conditions is mostly achieved using trial and error approaches and is thus a time-consuming process. In this study, we use the latest developments in the differential scanning fluorimetry guided refolding approach as an analytical method to detect correctly refolded protein. We describe a systematic buffer screen that contains a 96-well primary pH-refolding screen in conjunction with a secondary additive screen. Our research demonstrates that this approach could be applied for determining refolding conditions for several proteins. In addition, it revealed which “helper” molecules, such as arginine and additives are essential. Four different proteins: HA-RBD, MDM2, IL-17A and PD-L1 were used to validate our refolding approach. Our systematic protocol evaluates the impact of the “helper” molecules, the pH, buffer system and time on the protein refolding process in a high-throughput fashion. Finally, we demonstrate that refolding time and a secondary thermal shift assay buffer screen are critical factors for improving refolding efficiency.
The role of the immunoproteasome in interferon-γ-mediated microglial activation
Authors: Moritz Kasey E. , McCormack Nikki M. , Abera Mahlet B. , Viollet Coralie , Yauger Young J. , Sukumar Gauthaman , Dalgard Clifton L. , Burnett Barrington G.
Published: August 2017

Microglia regulate the brain microenvironment by sensing damage and neutralizing potentially harmful insults. Disruption of central nervous system (CNS) homeostasis results in transition of microglia to a reactive state characterized by morphological changes and production of cytokines to prevent further damage to CNS tissue. Immunoproteasome levels are elevated in activated microglia in models of stroke, infection and traumatic brain injury, though the exact role of the immunoproteasome in neuropathology remains poorly defined. Using gene expression analysis and native gel electrophoresis we characterize the expression and assembly of the immunoproteasome in microglia following interferon-gamma exposure. Transcriptome analysis suggests that the immunoproteasome regulates multiple features of microglial activation including nitric oxide production and phagocytosis. We show that inhibiting the immunoproteasome attenuates expression of pro-inflammatory cytokines and suppresses interferon-gamma-dependent priming of microglia. These results imply that targeting immunoproteasome function following CNS injury may attenuate select microglial activity to improve the pathophysiology of neurodegenerative conditions or the progress of inflammation-mediated secondary injury following neurotrauma.
Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes
Authors: Ishizu Takamaru , Higo Shuichiro , Masumura Yuki , Kohama Yasuaki , Shiba Mikio , Higo Tomoaki , Shibamoto Masato , Nakagawa Akito , Morimoto Sachio , Takashima Seiji , Hikoso Shungo , Sakata Yasushi
Published: August 2017

Although high-throughput sequencing can elucidate the genetic basis of hereditary cardiomyopathy, direct interventions targeting pathological mutations have not been established. Furthermore, it remains uncertain whether homology-directed repair (HDR) is effective in non-dividing cardiomyocytes. Here, we demonstrate that HDR-mediated genome editing using CRISPR/Cas9 is effective in non-dividing cardiomyocytes. Transduction of adeno-associated virus (AAV) containing sgRNA and repair template into cardiomyocytes constitutively expressing Cas9 efficiently introduced a fluorescent protein to the C-terminus of Myl2. Imaging-based sequential evaluation of endogenously tagged protein revealed that HDR occurs in cardiomyocytes, independently of DNA synthesis. We sought to repair a pathological mutation in Tnnt2 in cardiomyocytes of cardiomyopathy model mice. An sgRNA that avoided the mutated exon minimized deleterious effects on Tnnt2 expression, and AAV-mediated HDR achieved precise genome correction at a frequency of ~12.5%. Thus, targeted genome replacement via HDR is effective in non-dividing cardiomyocytes, and represents a potential therapeutic tool for targeting intractable cardiomyopathy.
Formation of a-plane facets in three-dimensional hexagonal GaN structures for photonic devices
Authors: Lim Seung-Hyuk , Sim Young Chul , Yoo Yang-Seok , Choi Sunghan , Lee Sangwon , Cho Yong-Hoon
Published: August 2017

Control of the growth front in three-dimensional (3D) hexagonal GaN core structures is crucial for increased performance of light-emitting diodes (LEDs), and other photonic devices. This is due to the fact that InGaN layers formed on different growth facets in 3D structures exhibit various band gaps which originate from differences in the indium-incorporation efficiency, internal polarization, and growth rate. Here, a-plane {$${\bf{11}}\bar{{\bf{2}}}{\bf{0}}$$
11

2
¯

0
} facets, which are rarely formed in hexagonal pyramid based growth, are intentionally fabricated using mask patterns and adjustment of the core growth conditions. Moreover, the growth area covered by these facets is modified by changing the growth time. The origin of the formation of a-plane {$${\bf{11}}\bar{{\bf{2}}}{\bf{0}}$$
11

2
¯

0
} facets is also discussed. Furthermore, due to a growth condition transition from a 3D core structure to an InGaN multi-quantum well, a growth front transformation (i.e., a transformation of a-plane {$${\bf{11}}\bar{{\bf{2}}}{\bf{0}}$$
11

2
¯

0
} facets to semi-polar {$${\bf{11}}\bar{{\bf{2}}}{\bf{2}}$$
11

2
¯

2
} facets) is directly observed. Based on our understanding and control of this novel growth mechanism, we can achieve efficient broadband LEDs or photovoltaic cells.
Morphology control of exciton fine structure in polar and nonpolar zinc sulfide nanorods
Authors: Baskoutas Sotirios , Zeng Zaiping , Garoufalis Christos S. , Bester Gabriel
Published: August 2017

Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active (“bright”) and passive (“dark”) states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations the exciton fine structure in colloidal polar and nonpolar zinc sulfide (ZnS) nanorods (NRs). We explore that polar NRs with high symmetry exhibit vanishing fine structure splitting (FSS), and are therefore ideal sources of entangled photon pairs. In contrast, nonpolar NRs grown along $$[\mathrm{11}\bar{{\bf{2}}}0]$$
[
11

2
¯

0
]
and $$[\mathrm{10}\bar{{\bf{1}}}1]$$
[
10

1
¯

1
]
directions with reduced symmetries have significant FSS, which can even reach up to a few mili electron volts. However, such large FSS can be effectively minimized to a few micro electron volts, or even less, by a simple morphology control.
Fine particulate matter 2.5 exerted its toxicological effect by regulating a new layer, long non-coding RNA
Authors: Huang Qiansheng , Chi Yulang , Deng Junjun , Liu Yiyao , Lu Yanyang , Chen Jinsheng , Dong Sijun
Published: August 2017

Fine particulate matter (PM2.5) exposure, especially to its organic components, induces adverse health effects on the respiratory system. However, the molecular mechanisms have still not been fully elucidated. Long non-coding RNA (lncRNA) is involved in various physio-pathological processes. In this study, the roles of lncRNA were investigated to reveal the toxicology of PM2.5. Organic extracts of PM2.5 from Nanjing and Shanghai cities were adopted to treat human bronchial epithelial cell lines (BEAS-2B and A549). RNA sequencing showed that the lncRNA functioned as antisense RNA, intergenic RNA and pre-miRNA. The mRNA profiles were also altered after exposure. PM2.5 from Nanjing showed a more serious impact than that from Shanghai. In detail, higher expression of n405968 was positively related to the elevated mRNA levels of inflammatory factors (IL-6 and IL-8). Increasing levels of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) were positively associated with the induced epithelial-mesenchymal transition (EMT) process. Similar response was observed between both cell lines. The higher content of polycyclic aromatic hydrocarbons (PAHs) is likely to contribute to higher toxicity of PM2.5 from Nanjing than that from Shanghai. Antagonism of aryl hydrocarbon receptor (AHR) or inhibition of CYP1A1 diminished the effects stimulated by PM2.5. Our results indicated that lncRNAs could be involved in the toxicology of PM2.5 through regulating the inflammation and EMT process.
Estrogen receptor α/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks
Authors: Dayoub Ousama , Le Lay Soazig , Soleti Raffaella , Clere Nicolas , Hilairet Gregory , Dubois Séverine , Gagnadoux Frédéric , Boursier Jérôme , Martínez Maria Carmen , Andriantsitohaina Ramaroson
Published: August 2017

Delphinidin, an anthocyanin present in red wine, has been reported to preserve the integrity of endotheliumviaan estrogen receptor alpha (ERα)-dependent mechanism. However, the effect of delphinidin on the immune response in obesity-related inflammation remains unknown. Given the important role of T lymphocytes in obesity-related inflammation, we investigated the effect of delphinidin on proliferation and differentiation of T lymphocytes from healthy subjects and metabolic syndrome patients. Delphinidin decreased the proliferation stimulated by different agents acting through different mechanisms. This effect of delphinidin was associated with its ability to inhibit Ca2+signaling via reduced store-operated Ca2+entry and release, and subsequent decrease of HDAC and NFAT activations. Delphinidin also inhibited ERK1/2 activation. Pharmacological inhibition of ER with fulvestrant, or deletion of ERα, prevented the effect of delphinidin. Further, delphinidin suppressed the differentiation of T cells toward Th1, Th17 and Treg without affecting Th2 subsets. Interestingly, delphinidin inhibited both proliferation and differentiation of T cells taken from patients with cardiovascular risks associated with metabolic syndrome. Together, we propose that delphinidin, by acting on ERα via multiple cellular targets, may represent a new approach against chronic inflammation associated with T lymphocyte activation, proliferation and differentiation, in patients with cardiovascular risk factors.
Hypermasculinised facial morphology in boys and girls with Autism Spectrum Disorder and its association with symptomatology
Authors: Tan Diana Weiting , Gilani Syed Zulqarnain , Maybery Murray T. , Mian Ajmal , Hunt Anna , Walters Mark , Whitehouse Andrew J. O.
Published: August 2017

Elevated prenatal testosterone exposure has been associated with Autism Spectrum Disorder (ASD) and facial masculinity. By employing three-dimensional (3D) photogrammetry, the current study investigated whether prepubescent boys and girls with ASD present increased facial masculinity compared to typically-developing controls. There were two phases to this research. 3D facial images were obtained from a normative sample of 48 boys and 53 girls (3.01–12.44 years old) to determine typical facial masculinity/femininity. The sexually dimorphic features were used to create a continuous ‘gender score’, indexing degree of facial masculinity. Gender scores based on 3D facial images were then compared for 54 autistic and 54 control boys (3.01–12.52 years old), and also for 20 autistic and 60 control girls (4.24–11.78 years). For each sex, increased facial masculinity was observed in the ASD group relative to control group. Further analyses revealed that increased facial masculinity in the ASD group correlated with more social-communication difficulties based on the Social Affect score derived from the Autism Diagnostic Observation Scale-Generic (ADOS-G). There was no association between facial masculinity and the derived Restricted and Repetitive Behaviours score. This is the first study demonstrating facial hypermasculinisation in ASD and its relationship to social-communication difficulties in prepubescent children.
Infection increases vulnerability to climate change via effects on host thermal tolerance
Authors: Greenspan Sasha E. , Bower Deborah S. , Roznik Elizabeth A. , Pike David A. , Marantelli Gerry , Alford Ross A. , Schwarzkopf Lin , Scheffers Brett R.
Published: August 2017

Unprecedented global climate change and increasing rates of infectious disease emergence are occurring simultaneously. Infection with emerging pathogens may alter the thermal thresholds of hosts. However, the effects of fungal infection on host thermal limits have not been examined. Moreover, the influence of infections on the heat tolerance of hosts has rarely been investigated within the context of realistic thermal acclimation regimes and potential anthropogenic climate change. We tested for effects of fungal infection on host thermal tolerance in a model system: frogs infected with the chytrid Batrachochytrium dendrobatidis. Infection reduced the critical thermal maxima (CTmax) of hosts by up to ~4 °C. Acclimation to realistic daily heat pulses enhanced thermal tolerance among infected individuals, but the magnitude of the parasitism effect usually exceeded the magnitude of the acclimation effect. In ectotherms, behaviors that elevate body temperature may decrease parasite performance or increase immune function, thereby reducing infection risk or the intensity of existing infections. However, increased heat sensitivity from infections may discourage these protective behaviors, even at temperatures below critical maxima, tipping the balance in favor of the parasite. We conclude that infectious disease could lead to increased uncertainty in estimates of species’ vulnerability to climate change.
Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cells
Authors: Takei Norio , Yoneda Akihiro , Sakai-Sawada Kaori , Kosaka Marina , Minomi Kenjiro , Tamura Yasuaki
Published: August 2017

Endoplasmic reticulum disulphide oxidase 1α (ERO1α) is an oxidase localized in the endoplasmic reticulum that plays a role in the formation of disulphide bonds of secreted and cell-surface proteins. We previously showed that ERO1α is overexpressed in various types of cancer and we further identified ERO1α expression as a novel factor related to poor prognosis in cancer. However, the biological functions of ERO1α in cancer remain unclear. Here, we investigated the cell biological roles of ERO1α in the human colon-cancer cell line HCT116. ERO1α knockout (KO) by using CRISPR/Cas9 resulted in decreased tumourigenicity in vivo and reduced cell proliferation only under hypoxia in vitro, which suggested that ERO1α promotes cancer progression specifically in a low-oxygen environment. Thus, we evaluated the function of ERO1α in cell proliferation under hypoxia, and found that under hypoxic conditions, ERO1α KO resulted in a contact-inhibited morphology and diminished motility of cells. We further showed that ERO1α KO induced a change in integrin-β1 glycosylation and thus an attenuation of cell-surface integrin-β1 expression, which resulted in the aforementioned phenotype. Our study has established a previously unrecognized link between ERO1α expression and integrin activation, and thus provides new evidence for the effectiveness of ERO1α-targeted therapy for colorectal carcinoma.
The adjuvant value of Herba Cistanches when used in combination with statin in murine models
Authors: Wat Elaine , Ng Chun Fai , Koon Chi Man , Zhang Cheng , Gao Si , Tomlinson Brian , Lau Clara Bik San
Published: August 2017

Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The objective of this study was to determine if the aqueous extract of HC (HCE) could prevent simvastatin-induced muscle toxicity in rats, and whether HCE could also exert beneficial effects on reducing high-fat diet-induced hypercholesterolemia and elevated liver cholesterol, thereby reducing the dose of simvastatin when used in combined therapy. From our results, HCE significantly restored simvastatin-induced reduction in muscle weights and reduced elevated plasma creatine kinase in rats. HCE also improved simvastatin-induced reduction in muscle glutathione levels, muscle mitochondrial membrane potential, and reduced simvastatin-induced muscle inflammation. Furthermore, HCE could exert reduction on liver weight, total liver lipid levels and plasma lipid levels in high-fat-fed mice. In conclusion, our study provided in vivo evidence that HCE has potential protective effect on simvastatin-induced toxicity in muscles, and also beneficial effects on diet-induced non-alcoholic fatty liver and hyperlipidemia when being used alone or in combination with simvastatin at a reduced dose.
Genetic deficiency in neuronal peroxisomal fatty acid β-oxidation causes the interruption of dauer development in Caenorhabditis elegans
Authors: Park Saeram , Paik Young-Ki
Published: August 2017

Although peroxisomal fatty acid (FA) β-oxidation is known to be critical for animal development, the cellular mechanisms that control the manner in which its neuronal deficiency causes developmental defects remain unclear. To elucidate the potential cellular consequences of neuronal FA metabolic disorder for dauer development, an alternative developmental process in Caenorhabditis elegans that occurs during stress, we investigated the sequential effects of its corresponding genetic deficiency. Here, we show that the daf-22 gene in peroxisomal FA β-oxidation plays a distinct role in ASK neurons, and its deficiency interrupts dauer development even in the presence of the exogenous ascaroside pheromones that induce such development. Un-metabolized FAs accumulated in ASK neurons of daf-22 mutants stimulate the endoplasmic reticulum (ER) stress response, which may enhance the XBP-1 activity that promotes the transcription of neuronal insulin-like peptides. These sequential cell-autonomous reactions in ASK neurons then activate insulin/IGF-1 signaling, which culminates in the suppression of DAF-16/FOXO activity. This suppression results in the interruption of dauer development, independently of pheromone presence. These findings suggest that neuronal peroxisomal FA β-oxidation is indispensable for animal development by regulating the ER stress response and neuroendocrine signaling.
Dynamic Image Analysis To Evaluate Subvisible Particles During Continuous Drug Infusion In a Neonatal Intensive Care Unit
Authors: Perez Maxime , Décaudin Bertrand , Maiguy-Foinard Aurélie , Barthélémy Christine , Lebuffe Gilles , Storme Laurent , Odou Pascal
Published: August 2017

Studies have shown that infused particles lead to numerous complications such as inflammation or organ dysfunctions in critically ill children. Nevertheless, there is very little data available to evaluate the amount of particulate matter potentially administered to patients, and none with regard to infants. We have investigated the quantity received by these patients during multidrug IV therapies. Two different protocols commonly used in our neonatal intensive care unit (NICU) to manage excessively preterm infants were reproduced in the laboratory and directly connected to a dynamic particle analyser. The particulate matter of infused therapies was measured over 24 h, so that both overall particulate contamination and particle sizes could be determined. No visible particles were observed during drug infusions. Particulate analyses showed a significant number of particles that can reach 85,000 per day, with peaks during discontinuous drug infusions. Moreover, we showed that very large particles of about 60 µm were infused to infants. This study showed that despite very low infusion flow rates, infants may receive a large number of particles during drug infusion, especially in NICUs. Particulate contamination of IV fluids is not without consequences for fragile infants. Preventive solutions could be effective, such as the use of in-line filters.
Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
Authors: Lou Hongfei , Ma Siyuan , Zhao Yan , Cao Feifei , He Fei , Liu Zhongyan , Bousquet Jean , Wang Chengshuo , Zhang Luo , Bachert Claus
Published: August 2017

Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Köppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT. 6340 (88.7%) patients had at least one positive skin prick reaction, and demonstrated unique sensitization patterns by stratification with age, gender, and geographic region. Sensitization to house dust mites (HDM) was highest in south China, whereas the three most prevalent aeroallergens were mugwort, ragweed and dandelion pollen in north-west China. Higher sensitization rates and multiple sensitizations were associated with AR comorbidities. Eight allergens (Der f, mugwort, Blatella, hazel, goosefoot, Penicillium notatum, animal dander and Der p) allowed identification >96% of sensitized subjects in central China. Differences in optimal panels were observed between regions, with five to six allergens being sufficient for north-east, north-west and south China. These SPT panels may provide a cost-effective tool for screening sensitized patients in China.
Resveratrol accumulation and its involvement in stilbene synthetic pathway of Chinese wild grapes during berry development using quantitative proteome analysis
Authors: Li Ruimin , Xie Xiaoqing , Ma Fuli , Wang Dan , Wang Lan , Zhang Jianxia , Xu Yan , Wang Xiping , Zhang Chaohong , Wang Yuejin
Published: August 2017

Attention has become focused on resveratrol not only because of its role in grapevine fungal resistance but also because of its benefits in human health. This report describes the Chinese wild grapevine Vitis quinquangularis accession Danfeng-2 in relation to the high resveratrol content of its ripe berries. In this study, we used isobaric tags for relative and absolute quantification (iTRAQ) tandem mass spectrometry strategy to quantify and identify proteome changes, resulting in the detection of a total of 3,751 proteins produced under natural conditions. Among the proteins quantified, a total of 578 differentially expressed proteins were detected between Danfeng-2 and Cabernet Sauvignon during berry development. Differentially expressed proteins are involved in secondary metabolism, biotic stress, abiotic stress and transport activity and indicate novel biological processes in Chinese wild grapevine. Eleven proteins involved in phenylpropanoid metabolism and stilbene synthesis were differently expressed between Danfeng-2 and Cabernet Sauvignon at the veraison stage of berry development. These findings suggest that Chinese wild V. quinquangularis accession Danfeng-2 is an extremely important genetic resource for grape breeding and especially for increasing the resveratrol content of European grape cultivars for disease resistance and for improved human nutritional benefits.
Using Feedback Control to Reduce Limb Impedance during Forceful Contractions
Authors: Hu Xiao , Ludvig Daniel , Murray Wendy M. , Perreault Eric J.
Published: August 2017

Little is known about the ability to precisely regulate forces or torques during unexpected disturbances, as required during numerous tasks. Effective force regulation implies small changes in force responding to externally imposed displacements, a behavior characterized by low limb impedance. This task can be challenging, since the intrinsic impedance of muscles increases when generating volitional forces. The purpose of this study was to examine the ability to voluntarily reduce limb impedance during force regulation, and the neural mechanisms associated with that ability. Small displacement perturbations were used to quantify elbow impedance during the exertion of volitional elbow torques from 0% to 20% of maximum voluntary contraction. Subjects were instructed either to not intervene with the imposed perturbations or to explicitly intervene so as to minimize the influence of the perturbations on the elbow torque. Our results demonstrated that individuals can reduce the low frequency components of elbow impedance by 35%. Electromyographic analysis suggested that this behavior is mediated by volitional and possibly long-latency reflex pathways with delays of at least 120 ms. These results provide a context for understanding how feedback altered by aging or injuries may influence the ability to regulate forces precisely.
Isolation, structure elucidation and racemization of (+)- and (−)-pratensilins A–C: unprecedented spiro indolinone-naphthofuran alkaloids from a marine Streptomyces sp.
Authors: Zhang Shumin , Yang Qin , Guo Lin , Zhang Ying , Feng Lingling , Zhou Ling , Yang Shengxiang , Yao Qingshou , Pescitelli Gennaro , Xie Zeping
Published: August 2017

Three pairs of new enantiomeric alkaloids with an unprecedented spiro indolinone-naphthofuran skeleton were isolated from a marine Streptomyces sp.
Water-soluble clickable nucleic acid (CNA) polymer synthesis by functionalizing the pendant hydroxyl
Authors: Liu Zhenzhen , Fairbanks Benjamin , He Liangcan , Liu Tao , Shah Parag , Cha Jennifer N. , Stansbury Jeffrey W. , Bowman Christopher N.
Published: August 2017

Water-soluble single stranded DNA analogs are generated via thiol–ene photo-oligomerization.
Adducts of aqua complexes of Ln3+ with a di-hydroxylated symmetrical octamethyl-substituted cucurbituril: potential applications for isolation of heavier lanthanides
Authors: Shen Fang-Fang , Chen Kai , Hua Zi-Yi , Wang Yuan , Xu Jing , Chen Min-Dong , Zhang Yun-Qian , Tao Zhu
Published: August 2017

In the present work, we have demonstrated that t(OH)2OMeQ[6] could be used for isolating heavy lanthanides from their lighter counterparts.
Photoinduced dimerization of a photosensory DNA-binding protein EL222 and its LOV domain
Authors: Takakado Akira , Nakasone Yusuke , Terazima Masahide
Published: August 2017

Blue light sensor protein EL222, which regulates DNA-binding affinity, exhibits photoinduced dimerization in the absence of target DNA.
Carrier relaxation dynamics in type-II ZnO/CdSe quantum dot heterostructures
Authors: Verma Sandeep , Ghosh Hirendra N.
Published: August 2017

Hot electron transfer from CdSe to ZnO in core/shell quantum dots before the onset of carrier cooling in CdSe shell.
Towards full-spectrum (UV, visible, and near-infrared) photocatalysis: achieving an all-solid-state Z-scheme between Ag2O and TiO2 using reduced graphene oxide as the electron mediator
Authors: Hu Xiaolin , Liu Xiang , Tian Jian , Li Yujie , Cui Hongzhi
Published: August 2017

We prepare an all-solid-state Z-scheme photocatalyst (RGO–Ag2O/TiO2 composites) for photocatalytic degradation of tetracycline under UV, visible and NIR light irradiation.
NIR emission and luminescent sensing of a lanthanide–organic framework with Lewis basic imidazole and pyridyl sites
Authors: Liu Le-Hui , Qiu Xing-Tai , Wang Yong-Jiang , Shi Qing , Sun Yan-Qiong , Chen Yi-Ping
Published: August 2017

Three luminescent lanthanide–organic frameworks, [Ln(Himdc)(ina)(H2O)]n, consist of a 3D microporous lanthanide carboxylate ([Eu(COO)3]n) framework and imidazole and pyridyl sites for the luminescent sensor.
Preparation and antithrombotic activity identification of Perinereis aibuhitensis extract: a high temperature and wide pH range stable biological agent
Authors: Li Yang , Li Jing , Liu Tianhong , Wang Ying , Zhou Zhongzheng , Cheng Feng , Feng Chao , Cheng Xiaojie , Liu Hongjun , Chen Xiguang
Published: August 2017

In this work, a thermal and wide pH range stable biological agent was extracted from Perinereis aibuhitensis, whose antithrombotic activity was investigated.
Synthesis of ethanol from paraformaldehyde, CO2 and H2
Authors: Zhang Jingjing , Qian Qingli , Cui Meng , Chen Chunjun , Liu Shuaishuai , Han Buxing
Published: August 2017

Ethanol is highly efficiently produced from paraformaldehyde, CO2 and H2 by homogeneous catalysis under mild conditions.
Proteomic and genetic analysis of the response of S. cerevisiae to soluble copper leads to improvement of the antimicrobial function of cellulosic copper nanoparticles
Authors: Rong-Mullins Xiaoqing , Winans Matthew J. , Lee Justin B. , Lonergan Zachery R. , Pilolli Vincent A. , Weatherly Lyndsey M. , Carmenzind Thomas W. , Jiang Lihua , Cumming Jonathan R. , Oporto Gloria S. , Gallagher Jennifer E. G.
Published: August 2017

Copper (Cu) was used in antiquity to prevent waterborne and food diseases because, as a broad-spectrum antimicrobial agent, it generates reactive oxygen species, ROS.
Photoinduced electron transfer between quantum dots and pralidoxime: an efficient sensing strategy
Authors: Jose A. R. , Vikraman A. E. , Girish Kumar K.
Published: August 2017

Photoinduced electron transfer (PET)-mediated fluorescence quenching of CdTe/CdS quantum dots by pralidoxime (PAM).
Facile synthesis of mesoporous carbon nitride and titanium dioxide nanocomposites with enhanced visible light photocatalytic activity
Authors: Thind Sapanbir S. , Mustapic Christian C. , Wen Jiali , Goodwin Carl D. , Chen Aicheng
Published: August 2017

C3N4–TiO2 nanocomposites with a large surface area and strong visible light response were fabricated via a rapid solution combustion method.
Self-rectifying bipolar resistive switching memory based on an iron oxide and graphene oxide hybrid
Authors: Oh Se-I , Rani Janardhanan R. , Hong Sung-Min , Jang Jae-Hyung
Published: August 2017

A solution-processed FeOx–GO hybrid based RRAM device with excellent self-rectifying characteristics (ILRS/IR > 104) is presented.
High-energy asymmetric supercapacitors based on free-standing hierarchical Co–Mo–S nanosheets with enhanced cycling stability
Authors: Balamurugan Jayaraman , Li Chao , Peera Shaik Gouse , Kim Nam Hoon , Lee Joong Hee
Published: August 2017

A layered, multifaceted, and free-standing hierarchical Co–Mo–S nanosheet architecture was successfully fabricated via anion exchange technique for high-performance ASC applications.
Controlled electrochemical doping of graphene-based 3D nanoarchitecture electrodes for supercapacitors and capacitive deionisation
Authors: Abdelkader A. M. , Fray D. J.
Published: August 2017

Porous electrodes of nitrogen-doped graphene were fabricated by a simple electrochemical process and used for energy storage and water desalination.
Morphometric characterization of fibrinogen's αC regions and their role in fibrin self-assembly and molecular organization
Authors: Protopopova Anna D. , Litvinov Rustem I. , Galanakis Dennis K. , Nagaswami Chandrasekaran , Barinov Nikolay A. , Mukhitov Alexander R. , Klinov Dmitry V. , Weisel John W.
Published: August 2017

High-resolution atomic force microscopy imaging reveals the role of fibrinogen αC regions in the early stages of fibrin self-assembly.
Optimal geometrical design of inertial vibration DC piezoelectric nanogenerators based on obliquely aligned InN nanowire arrays
Authors: Ku Nai-Jen , Liu Guocheng , Wang Chao-Hung , Gupta Kapil , Liao Wei-Shun , Ban Dayan , Liu Chuan-Pu
Published: August 2017

An improved design of direct-current nanogenerators using oblique InN nanowire arrays, which can be bent by their own weight, without any AC/DC converters.
7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new seco-casbane family member
Authors: Vanden Berg Timothy J. , Pinkerton David M. , Williams Craig M.
Published: August 2017

The firstseco-casbane, EBC-329, isolated from the Australian rainforest, was synthesised from (+)-2-carene in seven steps.
Novel pyrrolobenzodiazepine and pyrroloquinazoline scaffolds synthesized by a simple and highly selective Ugi/cyclization sequence
Authors: Pertejo Pablo , Peña-Calleja Pablo , Carreira-Barral Israel , Quesada Roberto , Alejandro Cordero Nicolás , Javier Rodríguez Francisco , García-Valverde María
Published: August 2017

A simple Ugi/cyclization sequence furnishing two novel pyrrolo-fused N-heterocycle families selectively by controlling the temperature is described.
Intramolecular hydrogen bonding in conformationally semi-rigid α-acylmethane derivatives: a theoretical NMR study
Authors: Mota Antonio J. , Neuhold Jürgen , Drescher Martina , Lemouzy Sébastien , González Leticia , Maulide Nuno
Published: August 2017

Experimental and computational evidence for unusual intramolecular hydrogen-bonding interactions is presented and discussed.
Synthesis of quinolines via copper-catalyzed domino reactions of enaminones
Authors: Kaewmee Benyapa , Rukachaisirikul Vatcharin , Kaeobamrung Juthanat
Published: August 2017

Enaminones showcase synthetic utility for the synthesis of quinoline derivatives via copper-catalyzed domino reactions involving C–N bond formation, aldol reaction and dehydration.
Design and synthesis of thermoresponsive aliphatic polyethers with a tunable phase transition temperature
Authors: Isono Takuya , Miyachi Kana , Satoh Yusuke , Sato Shin-ichiro , Kakuchi Toyoji , Satoh Toshifumi
Published: August 2017

A comprehensive study of the synthesis and LCST-type thermoresponsive properties of poly(glycidyl ether) homopolymers and their copolymers is described.
Roles of reaction kinetics of CO2 on a PrBaCo2O5.5+δ surfaces
Authors: Xu Xing , Mace Brennan , Enriquez Erik , Bao Shanyong , Harrell Zach , Chen Chonglin , Whangbo Myung-Hwan
Published: August 2017

A symmetric PBCO/YSZ/PBCO cell (where PBCO refers to PrBaCo2O5.5+δ, and YSZ to yttria stabilized zirconia) was designed and fabricated for the investigation of the catalytic nature and reaction kinetics of CO2 on PBCO surfaces.
Super-hierarchical Ni/porous-Ni/V2O5 nanocomposites
Authors: Yue Yuan , Ma Lian , Sun Jingze , Jeong Hae-Kwon , Liang Hong
Published: August 2017

Super-hierarchical nanocomposites were designed and fabricated using a facile, low-cost, and environmentally-friendly method. The profound specific surface area and porosity increased heat dissipation for about 150 times.
Novel highly stable β-cyclodextrin fullerene mixed valent Fe-metal framework for quick Fenton degradation of alizarin
Authors: Gogoi Aniruddha , Navgire Madhukar , Sarma Kanak Chandra , Gogoi Parikshit
Published: August 2017

Degradation of alizarin by β-cyclodextrin supported magnetic nanoscaled fullerene/Fe3O4(CDFMNPs) catalyst in a heterogeneous Fenton reaction.
Deep eutectic solvents as performance additives in biphasic reactions
Authors: Lan Dongming , Wang Xuping , Zhou Pengfei , Hollmann Frank , Wang Yonghua
Published: August 2017

Deep eutectic solvents act as surfactants in biphasic (hydrophobic/aqueous) reaction mixtures enabling higher interfacial surface areas at lower mechanical stress as compared to simple emulsions.
In situ synthesis of g-C3N4/TiO2 heterostructures with enhanced photocatalytic hydrogen evolution under visible light
Authors: Zhang Hui , Liu Feng , Wu Hao , Cao Xin , Sun Jianhua , Lei Weiwei
Published: August 2017

C3N4 nanosheets/TiO2 nano-heterostructures have been synthesized via a novel method, exhibiting excellent photocatalytic hydrogen generation under visible light irradiation.
4,6-Dimethyl-2-mercaptopyrimidine as a potential leveler for microvia filling with electroplating copper
Authors: Tang Mingxing , Zhang Shengtao , Qiang Yujie , Chen Shijin , Luo Li , Gao Jingyao , Feng Li , Qin Zhongjian
Published: August 2017

Filling performance of microvia was defined as following equation:η= (A/B) × 100%.
Synthesis of chelating polyamine fibers and their adsorption properties for nickel(ii) ions from aqueous solution
Authors: Cui Jianlan , Li Yanru , Meng Jian , Zhong Congsan , Wang Peng
Published: August 2017

In this work, a novel fibrous material PA–PVAF has been prepared. In the adsorption experiments of Ni(ii), the fibrous material PA–PVAF showed excellent adsorption performance, which can be used as a promising adsorbent.
Detoxification of organophosphates using imidazole-coated Ag, Au and AgAu nanoparticles
Authors: Silva Valmir B. , Rodrigues Thenner S. , Camargo Pedro H. C. , Orth Elisa S.
Published: August 2017

Organophosphate (OP) detoxification is a worldwide problem due to the high stability of P–O bonds.
Electrospun magnetic CoFe2O4/Ag hybrid nanotubes for sensitive SERS detection and monitoring of the catalytic degradation of organic pollutants
Authors: Song Wei , Yang Zezhou , Ma Fuqiu , Chi Maoqiang , Zhao Bing , Lu Xiaofeng
Published: August 2017

We report on the synthesis of magnetic CoFe2O4/Ag hybrid nanotubes as both SERS substrate and catalyst to monitor the catalytic degradation process of organic pollutants.
Effect of soft segment molecular weight on the glass transition, crystallinity, molecular mobility and segmental dynamics of poly(ethylene oxide) based poly(urethane–urea) copolymers
Authors: Oguz Oguzhan , Koutsoumpis Stefanos A. , Simsek Eren , Yilgor Emel , Yilgor Iskender , Pissis Polycarpos , Menceloglu Yusuf Z.
Published: August 2017

The effect of poly(ethylene oxide) (PEO) soft segment molecular weight (Mn= 2000, 4600, 8000 g mol−1) molecular mobility and segmental dynamics of a series of polyurethane–urea copolymers (PU) was investigated by dielectric relaxation spectroscopy.
Liquid–liquid microflow reaction engineering
Authors: Wang Kai , Li Liantang , Xie Pei , Luo Guangsheng
Published: August 2017

Engineering characteristics of liquid–liquid microflow and its advantages in chemical reactions.
Visible-light/temperature dual-responsive hydrogel constructed by α-cyclodextrin and an azobenzene linked surfactant
Authors: Wang Jiao , Li Qintang , Yi Sijing , Chen Xiao
Published: August 2017

A visible light/temperature dual responsive supramolecular hydrogel was successfully fabricated by simply mixing DAH with double the amount of α-CD.
Two-dimensional island emulsions in ultrathin, freely-suspended smectic liquid crystal films
Authors: Radzihovsky Sarah P. , Cranfill Chaney , Nguyen Zoom , Park Cheol S. , Maclennan Joseph E. , Glaser Matthew A. , Clark Noel A.
Published: August 2017

We report a novel type of two-dimensional colloidal emulsion, in which arrays of disc-shaped liquid crystal domains are created in ultrathin, freely-suspended, fluid smectic C liquid crystal films.
Recent advances in Fe (or Co)/N/C electrocatalysts for the oxygen reduction reaction in polymer electrolyte membrane fuel cells
Authors: Sun Tao , Tian Bingbing , Lu Jiong , Su Chenliang
Published: August 2017

Exploring cheap and stable electrocatalysts to replace Pt for the oxygen reduction reaction (ORR) is significant for the large-scale application of fuel cells, especially in polymer electrolyte membrane fuel cells. In this paper, we have briefly reviewed the recent advances in the Fe (or Co)/N/C ORR catalysts in acidic medium including their preparation, structural characterization and related mechanism.
Synthesis and use of a hyper-connecting cross-linking agent in the hole-transporting layer of perovskite solar cells
Authors: Watson Brian L. , Rolston Nicholas , Bush Kevin A. , Taleghani Leila , Dauskardt Reinhold H.
Published: August 2017

Solution-processed organic semiconducting materials feature prominently in modern optoelectronic devices, especially where low-cost and flexibility are specific goals, such as perovskite solar cells.
A novel strategy for the synthesis of sulfur-doped carbon nanotubes as a highly efficient Pt catalyst support toward the methanol oxidation reaction
Authors: Fan Jing-Jing , Fan You-Jun , Wang Rui-Xiang , Xiang Sheng , Tang Hua-Guo , Sun Shi-Gang
Published: August 2017

Sulfur-doped multi-walled carbon nanotubes (S-MWCNTs) derived from PEDOT-functionalized MWCNTs can significantly improve the dispersion of supported Pt nanoparticles and enhance their electrocatalytic performance for the MOR.
Iron oxyfluorides as lithium-free cathode materials for solid-state Li metal batteries
Authors: Wang Li-Ping , Wang Tai-Shan , Zhang Xu-Dong , Liang Jia-Yan , Jiang Li , Yin Ya-Xia , Guo Yu-Guo , Wang Chun-Ru
Published: August 2017

High energy density storage systems can be achieved by utilizing a lithium metal anode in solid-state Li secondary batteries.
A core–shell fiber-constructed pH-responsive nanofibrous hydrogel membrane for efficient oil/water separation
Authors: Zang Linlin , Ma Jun , Lv Dongwei , Liu Qingliang , Jiao Wenling , Wang Panpan
Published: August 2017

A core–shell fiber-constructed pH-responsive nanofibrous hydrogel membrane was fabricated for gravity-driven oil/water separation in acid, neutral, and alkali environments.
Boosting CO2 electroreduction over layered zeolitic imidazolate frameworks decorated with Ag2O nanoparticles
Authors: Jiang Xiaole , Wu Haihua , Chang Sujie , Si Rui , Miao Shu , Huang Weixin , Li Yanshuo , Wang Guoxiong , Bao Xinhe
Published: August 2017

The Ag2O/layered zeolitic imidazolate framework (ZIF) composite material shows much higher CO faradaic efficiency and current density than the layered ZIF or Ag/C alone towards CO2 electroreduction.
Tuning Voc for high performance organic ternary solar cells with non-fullerene acceptor alloys
Authors: Chen Yusheng , Ye Pan , Jia Xiangli , Gu Wenxing , Xu Xiaozhou , Wu Xiaoxi , Wu Jianfei , Liu Feng , Zhu Zhen-Gang , Huang Hui
Published: August 2017

A non-fullerene acceptor with a high Ne value is efficient to enhance Voc as the third component for OSCs, leading to an efficiency of ∼11%.
Highly efficient single-layer blue polymer light-emitting diodes based on hole-transporting group substituted poly(fluorene-co-dibenzothiophene-S,S-dioxide)
Authors: Peng Feng , Li Na , Ying Lei , Zhong Wenkai , Guo Ting , Cui Jing , Yang Wei , Cao Yong
Published: August 2017

We developed a series of high-performance blue light-emitting polymers that contain hole-transport moieties comprising carbazole or triphenylamine substituents in the side chains of random copolymer poly(fluorene-co-dibenzothiophene-S,S-dioxide) (PFSO).
Enhanced anti-counterfeiting measures for additive manufacturing: coupling lanthanide nanomaterial chemical signatures with blockchain technology
Authors: Kennedy Z. C. , Stephenson D. E. , Christ J. F. , Pope T. R. , Arey B. W. , Barrett C. A. , Warner M. G.
Published: August 2017

An anti-counterfeiting method is introduced by doping optically-active nanomaterials into printed parts, non-destructively measuring the part's chemical signatures arising from the taggants, and linking the resulting signature data to a blockchain.
Strong interfacial interaction and enhanced optical absorption in graphene/InAs and MoS2/InAs heterostructures
Authors: Ning Feng , Wang Dan , Feng Ye-Xin , Tang Li-Ming , Zhang Yong , Chen Ke-Qiu
Published: August 2017

Strong interfacial interaction, remarkable electron–hole pair distribution, and obviously enhanced optical absorption in graphene/InAs and MoS2/InAs heterostructures.
Analysis of speed disturbances in empirical single vehicle probe data before traffic breakdown
Authors: Molzahn Sven‐Eric , Kerner Boris S. , Rehborn Hubert , Klenov Sergey L. , Koller Micha
Published: August 2017

In single vehicle probe data measured on German freeways the authors have revealed free flow→synchronised flow→free flow transitions that occur before traffic breakdown at a bottleneck occurs. Thus resulting in the formation of a congested pattern. The empirical findings of these phase transitions confirm a recent microscopic stochastic theory of traffic breakdown developed by Kerner. Only because of the recently introduced possibility of gathering larger amounts of anonymised vehicle data – including a sequence of positions of each car – the authors are able to show the phenomenon of these phase transitions in measured floating car data. This contribution reveals empirical findings in microscopic data which support and prove some of the recent theoretical findings of the nature of traffic breakdown.
Signal censoring and fusing with system‐level communication constraints in multistatic radar: a J‐divergence and Bhattacharyya distance‐based approach
Authors: Cao Ding , Zhou Shenghua , Liu Hongwei , Liu Jun , Zang Huikai
Published: August 2017

Decentralised detection using censored observations is an effective way to mitigate communication constraints where each sensor only transmits the ‘informative’ observations to a fusion centre (FC), and censors those deemed ‘uninformative’. In this study, a censoring rule is used at each spatial diversity channel such that only the observation exceeding a local threshold is transmitted, where the local threshold controls the communication rate. In particular, the authors consider a scenario where there exists a communication constraint at the FC. To design a proper communication bandwidth allocation (CBA) algorithm, two Ali‐Silvey distance measures, i.e. the J‐divergence (JD) and Bhattacharyya distance (BD), are utilised as objective functions to achieve a manageable optimisation procedure for designing local thresholds. The CBA algorithm is proposed by solving a constrained non‐linear programming problem through the sequential quadratic programming method. Besides, the detection performance is analysed under the censoring scheme, given the optimised local thresholds. Numerical results indicate that the two Ali‐Silvey distance‐based algorithms can outperform the uniform bandwidth allocation strategy; meanwhile, the BD‐based method performs better at high signal‐to‐noise scenarios but slightly worse at low, compared with the JD‐based method.