bluuebunny/crossref_metadata_2025 huggingface dataset:
Model Pendekatan Bermain Dalam Upaya Meningkatkan Kebugaran Jasmani
Authors: Samosir Fifi , Aditya Rinaldi
Published: June 2022

Adapun tujuan penelitian ini adalah: “Model Pendekatan Bermain Dalam Upaya Meningkatkan Kebugaran Jasmani Pada Siswa Kelas V SD. Negeri No. 105432 Kp. Ampera Kec. Bandar Khalipah Kab. Serdang Bedagai Tahun Ajaran 2020/2021.” Desain pada penelitian ini adalah menggunakan pendekatan studi kasus dengan survei jurnal-jurnal ilmiah yang telah terakreditasi. Kajian penelitian ini merupakan kajian kualitatif dengan menganalisis kajian model pendekatan bermain yang dihubungkan dengan kebugaran jasmani. Berdasarkan kedua karakteristik antara model pendekatan bermain dapat diterapkan untuk meningkatkan kebugaran jasmani kelas V SD. Negeri No. 105432 Kp. Ampera Kec. Bandar Khalipah Kab. Serdang Bedagai dengan melaksanakan model pendekatan bermain yakni latihan lompat katak 10 meter, latihan back-up dengan teman, latihan gerobak dorong, lari menggunakan kombinasi rintangan dan lari 50 meter.
The Long Game: Growth Points and Prospects of Social Impact Bonds in Russia
Authors: Vyatkina Y.
Published: June 2022

Social Impact Bonds (SIB) are a form of social project implementation that brings together players from several sectors of the economy. This market is just emerging in Russia. About 200 million rubles (about $3 million) has been invested in social impact projects so far. After more than three years of SIB trials in Russia, only one project is nearing completion. However, stakeholders and professionals have had numerous discussions on the relevance, advantages and potential of the new model. We decided to ask experts about the prospects, constraints, and growth points for social impact bonds in Russia.
Big Break Ahead: Vectors for the Development of the New Children’s and Youth Movement
Authors: Vyatkina Y.
Published: June 2022

On May 19, 2022, on the centenary of the pioneer organization, a bill on the Russian children’s and youth movement called the Big Break was introduced into the State Duma. According to the authors, if passed into law, the bill would form the grounds for a unified children and youth education policy, improve the social engagement of young people, build a continuous development path based on the traditional values of the Russian society. Our editors asked experts on how the new movement should be working and what needs to be taken into account to create agents and bearers of positive changes and leadership in the country.
«Sandboxes» for Social Investments: How Social Impact Bonds Projects Are Developing Globally
Authors: Smekalin I.
Published: June 2022

The impact investment market is growing all over the world, and its forms and types are becoming more elegant. If earlier investments in solving social problems could be more like spending CSR budgets — “give and forget”, than the current state of the market dictates other rules. The new standard is accounting not only for invested funds but also for assessing the socio-economic efficiency of the results obtained. One of these “new” formats is the “SIBs” that came to Russia not so long ago — so-called from the English-language term Social Impact Bonds.
The School of the Future. Does It Have the Room for Soft Skills Development?
Authors: Talitskaya Z.
Published: June 2022

The so-called soft skills — a set of personal and social skills and qualities — are increasingly becoming the subject of studies and public discourse lately. However, school and University education still remains focused on knowledge. Will the School of the Future place as much emphasis to the development of soft skills as to substantive learning? We are starting a series of publications dedicated to the models of the School of the Future. Our first conversation is about what role the school plays in developing soft skills in children.
Russia — the Country of Positive Changes
Authors: Ryzhkov A.
Published: June 2022

Opinion piece by Alexey Ryzhkov.
Old New Challenges for the Cities of the Future. Trends, Risks and Opportunities of Modern Urbanization
Authors: Ivanov P.
Published: June 2022

Digital citizens, artificial intelligence, local agendas, new-format developers investing in social and natural capital — all these are attributes of the cities of the future. Urbanist Peter Ivanov reasons why it is sometimes necessary to turn to the past in order to learn about the future and what changes await the urban environment.
Case of Issue. The Use of the Contributive Analysis Methodology on the Case of the “Clean Games” Project
Authors: Smekalin I.
Published: June 2022

The Clean Games project started in St. Petersburg in 2014 as a simple volunteer initiative. The project leader Dmitry Ioffe once went hiking with his friends on Lake Vuoksa, but his vacation was spoiled by a landfill on one of the islands. That is how he came up with an idea for the first waste collection contest, which over eight years evolved into a series of eco-quests uniting 90,000 players in 26 countries. The participants collect up to 5 tons of waste in one game, most of which is then recycled. The project organizers had an ambitious goal: to raise the awareness and increase public engagement in the environmental agenda. How can one assess the social impact of the Clean Games and whether their ambitious goal has actually been met? One tool that can be used for this purpose is the qualitative approach based on analyzing the participants’ contributions — the contribution analysis method.
Impact Investing as an Object of Research. 2022 Publications Digest
Authors: Zakharova E.
Published: June 2022

A number of publications appeared by mid-2022, dedicated in one way or another to the issue of impact investing. Numerous articles, literature reviews and case studies attempt to identify the current status of the social investing sector and review the past experience — in other words, trying to figure out “where we are”.
Synthesis of 2-Substitutedbenzimidazolium Tetrachloroplatinate(II) Compounds and Their Cytotoxic Activities on Different Cell Lines
Authors: GÖZELLE Mahmut , KILIÇ SÜLOĞLU Aysun
Published: June 2022

The aim of the study was the synthesis of novel platinum compounds
having benzimidazole ligands and screening for their in vitro cytotoxic
activity on human cervical carcinoma HeLa, human lung carcinoma
A549, and human lung epithelial Beas-2B cell lines. 2-Substituted
benzimidazole ligands were synthesized by using appropriate
aldehydes and o-phenylenediamine. Subsequently, 2-substituted
benzimidazole ligands and potassium tetrachloroplatinate(II)
(K2PtCl4) were used to synthesize 2-isopropylbenzimidazole
tetrachloroplatinate(II) (K1) and 2-(1-methylpropyl)benzimidazole
tetrachloroplatinate(II) monohydrate (K2). HRMS, IR, elemental
analysis, 1H-NMR, and melting point were used to characterize
the synthesized compounds. Cytotoxic activities against HeLa,
A549, and Beas-2B cells after 48 h and 72 h incubation of the
platinum compounds were investigated via MTT assay. Cisplatin
and carboplatin were used as reference drugs. The cytotoxic activity
results showed that K2 platinum compound displayed 53.42%±2.21
(at 160 μM) on HeLa, 88.16%±0.22 (at 160 μM) on A549 and
92.09%±0.57 (at 160 μM) on Beas-2B after 48 h incubation, K2
displayed 27.42%±2.03 (at 160 μM) on HeLa, 93.95%±0.53
(at 160 μM) on A549 and 91.99±0.22 (at 160 μM) on Beas-2B
after 72 h incubation. Both of the platinum compounds have higher
cell inhibitory effects than reference drug carboplatin after 48 h incubation for tested cells.
Segmental testicular infarction in a 17-year-old teenager
Authors: Shedrov D. N. , Shormanov I. S. , Gаrova D. Yu. , Nagornova E. Yu.
Published: June 2022

EDITORIAL COMMENT. According to clinical data, segmental testicular infarction occurred due to transient testicular torsion with impaired arterial blood supply. Thus, in the presented clinical case, segmental testicular infarction should not be considered as a complication of varicocele.Introduction. Segmental testicular infarction in children and adolescents is a rare case that is mostly met as a complication of andrological or other diseases. This pathology is extremely difficult to diagnose. At the same time, in order to increase the chance for favorable outcomes, decision on the proper way of care must be taken as soon as possible.Purpose. To demonstrate a case of successful diagnostics and treatment of segmental testicular infarction in a teenager with varicocele.Material and methods. The patient was admitted with a picture of acute scrotum syndrome three hours later after the onset of the disease with preliminary diagnosis "testicular torsion and thrombosis of testicular veins in a patient with varicocele". Four days before, the patient consulted a urologist about pain in the left testicle. Varicocele grade III on the left without orchopathy was diagnosed. The pain syndrome was relieved by non-steroidal anti-inflammatory drugs. Previously, this pathology had not been diagnosed in this patient, and he did not suspect it. Examination of organs: no marked changes; locally, on the left, there is expansion of testicular veins of degree III; testicle on the left is painful, dense. Ultrasound examination and dopplerography of the scrotum organs were urgently made. Findings of radial examinations revealed segmental thrombosis in the middle part of the testicle; however, because of low occurrence of segmental thrombosis and greater focus on the testicular torsion the surgeons were not sure of absolute accuracy of the obtained additional findings. An emergency revision of the scrotum was performed at which the diagnosis of segmental thrombosis was confirmed. Three month later, at a follow-up examination partial restoration of blood flow in the infarction zone without pronounced signs of testicular atrophy was seen.Conclusion. Segmental testicular infarction is an extremely rare complication of varicocele in children and adolescents. A proper assessment of the clinical picture and ultrasound imaging allow to put the well-timed and correct diagnosis of segmental testicular infarction. Not in all cases, segmental testicular infarction should be considered as an irreversible condition that leads to sclerosis in its outcome.
PENGARUH PROMOSI ISLAMI DAN KUALITAS PELAYANAN ISLAMI TERHADAP KEPUTUSAN NASABAH MEMILIH BMT HASANAH
Authors: Saba' Firdaus Bilqis Ratu
Published: June 2022

The Effect of Islamic Promotion and Islamic Service Quality on Customer Decisions to Choose BMT Hasanah (Case study at BMT Hasanah, Sambit branch office). This study aims to (1) Identify and analyze the effect of Islamic promotion on customer decisions to choose BMT Hasanah, (2) Identify and analyze the quality of Islamic services on customer decisions to choose BMT Hasanah, (3) Identify and analyze the effect of Islamic promotion and Islamic service quality on customer's decision to choose BMT Hasanah. This type of research is quantitative research, using multiple linear analysis to analyze data and test hypotheses using the IBM SPSS version 23 application. This study has two independent variables, namely Islamic promotion and Islamic service quality, and one dependent variable, namely the customer's decision to choose BMT Hasanah. Data obtained from questionnaires that have been distributed to 60 respondents, namely BMT Hasanah customers who were selected through technique simple random sampling and measured by a likert scale. Based on the analysis performed by the researchers, it can be concluded that the partial test promotion variables Islami does not significantly influence the customer's decision choosing BMT Hasanah it is evidenced by t value the (0.551) <t table (2.002), so that the research hypothesis Ha rejected and H0 is accepted. Partial assay results Islami service quality variables showed a significant effect on the customer's decision to choose BMT Hasanah t value (4.980)> t table (2.002), so that the research hypothesis H0 is rejected and Ha accepted. The simultaneous test results of Islamic promotion variables and Islamic service quality on the customer's decision to choose BMT Hasanah show a significant effect, this is indicated by the value calculated (22.832> f table (3.18). So that the research hypothesis H0 is rejected and Ha is accepted. The value of Adjusted R Square is 0.425 or 42.5%, meaning that the Islamic promotion variable and Islamic service quality have an influence on the customer's decision to choose BMT Hasanah by 42.5%, while the remaining 57.5% is influenced by other variables not included in the research variable.
Pengaruh Motivasi Kerja dan Lingkungan Kerja Terhadap Kinerja Karyawan pada Dinas Peternakan Kabupaten Dompu
Authors: Hanif Muhammad Ghathfan , Asmony Thatok , Nururly Santi
Published: June 2022

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh Motivasi Kerja dan Lingkungan Kerja terhadap Kinerja Karyawan pada Dinas Peternakan Kabupaten Dompu. Penelitian ini menggunakan metode penelitian kuantitatif dengan penedekatan penelitian asosiatif. Sampel dalam penelitian ini sebanyak 58 responden. Metode analisis data menggunakan regresi linier berganda. Berdasarkan hasil penelitian disimpulkan bahwa variabel motivasi kerja dinyatakan berpengaruh positif dan signifikan terhadap kinerja karyawan Dinas Peternakan Kabupaten Dompu dan variabel lingkungan kerja dinyatakan berpengaruh positif dan signifikan terhadap kinerja karyawan Dinas Peternakan Kabupaten Dompu.
Paragraph Comprehension from the Perspective of Conjunctions and Structure under Structuralism
Authors: Yu Shuying
Published: June 2022

People frequently struggle with comprehending the text they read and require more intensive support to develop proficiency in reading comprehension. Some find it perplexing observing all the elements and constituents of the paragraph theory. Good readers, however, can understand what a paragraph is by studying the conjunction relationships between sentences and group of sentences in the paragraph and can also understand the organization of the text by analyzing the conjunction relationships in a paragraph or a text when they deal with a written text. Such analysis of the conjunction relationships in a paragraph or a text can be used as a basis for understanding how the author organizes and presents materials. The inspiration of structuralist view of education is that students need to learn and discover the structure of knowledge. The research methods of the paper are ones of knowledge, experience, observation, logical reasoning and keen analysis of English examples or materials. This paper provides guidance for the skills of logical relationship comprehension, text structure determination and main idea dentification, and introduces some practices of using the skills. These skills have brought us some findings: We can use the conjunction relationships between the sentences in a paragraph to determine the structure of the paragraph, whether they are signaled or unsignaled, including finding the main idea; The contextual clues can be adverbs, pronouns, nouns, verbs, and preposition groups besides conjunctions; Items in one type of relationships are of equal weight and one sentence in another type of relationships is given more importance than the others; There is a relationship between the type of conjunction relationship involved and the location of the topic sentence; The role of the main idea or topic sentence is not in whether it always provides important information, but in its organizational function. These findings guide readers to apply the knowledge of paragraph organization system to help them deal with English texts.
Educational Philosophy Adopted by Pre-Service Science Teachers
Authors: Bektas Oktay
Published: June 2022

This study aims to examine the thoughts of fourth-year pre-service science teachers about the nature of science. For this purpose, the study preferred the qualitative research method and phenomenology design. Participants consisted of nine pre-service science teachers. Participants wrote a self-evaluation report after the nature of the science course. I collected data with this report and focus-group interview. I did the data analysis using content analysis. The current study discusses validity and reliability. As a result of the analysis, pre-service science teachers stated that they learned the nature of science by adopting the constructivist philosophy. Therefore, they described that they will use the constructivist scientific language when they become teachers in the future. They argued that students should learn how scientific knowledge changes and develops. In addition, pre-service science teachers emphasized that teachers should direct their students’ learning processes according to the constructivist philosophy considering scientists’ culture, beliefs, and prior knowledge. They stated that students should understand the socio-cultural impact on the learning process. They also mentioned that students should use their imagination and creativity so that they can learn scientific information meaningfully. Based on these results, I suggested that teaching based on positivist philosophy would not remove the obstacles to students’ learning science.
Is the Eudaimonic or Hedonic Approach Contribute to Psychological Well-Being? An Empirical Study Amongst the UAE Talents as a Strategic Move in Firms
Authors: Parameswaran Hima
Published: June 2022

Nowadays, both businesses and researchers are overwhelmed with workers’ ideal health and safety to psychological well-being. Negative psychological health at work results in adverse effects at different levels: high medical insurance costs, loss of employee productivity, absenteeism from work, occupational safety and health issues, and related issues. The current study examines the roles of eudaimonic and hedonic motivation in the conceptualization of psychological well-being.  Both psychological aspects in one’s life significantly play in achieving personal growth, reaching full potential, and realizing self-actualization. Accordingly, the study was conducted in the education sectors in the UAE randomly. Various models assisted in preparing a questionnaire and distributed it to 300 respondents. The samples were selected by stratified proportional sampling for diverse demographic responses. A descriptive analysis using SPSS 24.0 maintained the significance level of the latent variables such as eudaimonic motivation and hedonic motivation to the dependent variable, psychological well-being. The findings confirmed the alignment of models, extracted from the theories to the variables discussed in the questionnaire. Moreover, the hypotheses crafted for the study were accepted. Consequently, the study proved that both hedonic and eudaimonic factors in an individual's life influence psychological well-being at work.  Hence, individuals must ensure the significance of job characteristics at their workplace to psychological well-being. Furthermore, it clarifies that the HR systems with an effective resource-based paradigm can contribute to a sustained competitive advantage. Finally, it proposes directions for future research in addressing issues in employee turnover in a resource-based approach.
Factors Affecting the Executive Function in Undergraduate Students
Authors: Navayuth Thadsnachai , Yurayat Phamornpun
Published: June 2022

This research aimed to 1) study the level of self-efficacy, self-awareness, social skills, and executive function of undergraduate students, 2) study the relationship among self-efficacy, self-awareness, social skills, and executive function of undergraduate students, and 3) investigate the effect of self-efficacy, self-awareness, and social skills on executive function in undergraduate students. The sample used in the study was 400 undergraduate students from Mahasarakham University in the academic year 2021, selected by multi-stage random sampling. The research instruments included four questionnaires including self-efficacy, self-awareness, social skills, and executive function questionnaire. The statistics used in the data analysis were percentage, mean (M), standard deviation (S.D.), and multiple regression analysis. The results revealed that 1) students’ self-efficacy, self-awareness, social skills, and executive function, in general, were at a very high level. 2) There were statistically significant at the .01 level correlations between students’ self-efficacy, self-awareness, social skills, and executive function. 3) Students’ self-efficacy (SELE), self-awareness (SELA), and social skills (SOCS) affected executive function, with a prediction of 70.20%.
A Management Analysis of Art Education Situation for Middle School Students in China
Authors: Wang Mingjun
Published: June 2022

This article analyzes the current domestic middle school art education and education management. Today, with great efforts to improve the quality of education, our domestic art education has been included in the education sequence of the compulsory education system. However, there are still some shortcomings in middle school art education. Combining with the current conditions of my country’s middle school art education, through investigation and analysis, it points out the key issues in the quality of middle school art education. The universality of middle school art education, and finally implements reasonable improvements.
The Use of Blogs on EFL Students’ Writing and Engagement in a Saudi Private School
Authors: Bahanshal Dalal A. , Alkubaidi Miriam A. , Alied Norah A.
Published: June 2022

The blog is one of the recent technologies in use for teaching, learning, and practicing writing (Aljumah, 2012). Blogs are an educational tool for continuous learning outside classrooms (Vurdien, 2013). The current study aims to add to the research on blogs in EFL writing by observing the writing development of EFL learners in a Saudi context. The study also investigates learners’ perceptions of utilizing blogs as tools to increase classroom engagement. The data are collected from 36 female high school students by analysing the students’ writing samples before and after the intervention, conducting a questionnaire at the end of the intervention, and interviewing select participants. Although the findings did not show any significant differences between the two writing samples, the responses from the surveys indicated positive perceptions of blogs in writing and of blogs as a tool for increasing engagement. The active interaction in peer feedback and class discussion revealed that the blog is a useful tool for learning writing.
Values Lost in Society in the Eyes of Teachers
Authors: KOÇ Sevgi
Published: June 2022

People’s actions are governed by their values, beliefs, perspectives, and world views. There is so much diversity that everyone has or creates their own moral standards, principles, and values, making social cohesion difficult. We come to a dead-end when we evaluate different moral standards and value systems from the perspective of relativity and absoluteness. People acquire values first in the family and then at school. Therefore, teachers play a crucial role in helping students adopt values and moral standards. This study investigated teachers’ views on values (especially lost values). This study adopted a qualitative research design (phenomenology). Data were collected using a semi-structured interview questionnaire developed by the researcher. The questionnaire consisted of six questions. The study sought answers to the following questions: What do teachers think about values and values education? What values do teachers think we have lost in society? Why do teachers think we have lost values in society? and How do teachers think we can get back the lost values? Participants viewed values as moral principles. They regarded values education as the type of education required for society to live in a healthy, harmonious, and peaceful way. They thought that we had lost the values of honesty, understanding, respect, etc. They believed that we had lost those values because of social media, changes in the institution of family, etc. They suggested that we provide students with values education courses and encourage school-family collaboration to get back the lost values.
GAMBARAN TINGKAT PENGETAHUAN REMAJA PUTRI TENTANG KEPUTIHAN DI SEKOLAH TINGGI ILMU KESEHATAN YOGYAKARTA
Authors: MELINA FITRIA
Published: June 2022

ABSTRACT

 

Background: Based on data from the World Health Organization (WHO), poor women's reproductive health problems have reached 33% of the total burden of disease suffered by women in the world, one of which is vaginal discharge (Oriza, 2018). According to (WHO), women rarely pay attention to the cleanliness of their external genitalia. Vaginal infections every year affect women worldwide 10-15% of 100 million women, for example, adolescents who are infected with candida bacteria around 15% and experience vaginal discharge

Research methods: This research method is descriptive. This research was conducted in July 2021. The sample in this study were students of STIkes Yogyakarta, totaling 32 respondents and using purposive sampling. The instrument in this study was a knowledge questionnaire

Results and discussion: The level of knowledge of young women about vaginal discharge in the sufficient category 15 respondents (46.9%), the level of knowledge about the meaning of vaginal discharge in the good category 15 respondents (46.9%), the level of knowledge of young women about the type of vaginal discharge in the sufficient category 17 respondents (53 ,1%), the level of knowledge of young women about the causes of vaginal discharge in the sufficient category 13 respondents 40.6%), the level of knowledge of young women about the signs and symptoms of vaginal discharge in the category of 16 respondents (50.0%), the level of knowledge of young women about prevention of vaginal discharge in the category enough 14 respondents (43.8), the level of knowledge of young women about the treatment of vaginal discharge in the sufficient category 15 people (46.9%) and the level of knowledge of young women about the treatment of vaginal discharge in the category less 25 respondents (78.1%).
Anaerobic dysbiosis of the cervical canal as a risk factor for premature rupture of membranes
Authors: Kaganova Maria A. , Spiridonova Natalya V. , Petyanova Viktoriya A. , Denisova Natalya G. , Syresina Svetlana V. , Petrov Maxim G. , Rodionova Natalya A. , Inyusheva Luiza S.
Published: June 2022

BACKGROUND: To identify the most significant predictors of premature rupture of membranes in full-term pregnancy with the use of RT-PCR analysis of cervical canal smear.

MATERIALS AND METHODS: On the basis of City Clinical Hospital No. 1 named after N.I. Pirogov (Samara), a cervical smear was examined by RT-PCR using a standard panel Femoflor-16. The study involved 47 pregnant women at 37-41 weeks of gestation: the control group consists of 19 pregnant women without premature rupture of the membranes (PROM), and 28 pregnant women with PROM, were included in the main group. The most significant risk factors of PROM were revealed with the use of the Classification Trees.

RESULTS: The following risk factors of PROM were identified: the number of Lactobacillus spp. less than 99.3% (sensitivity 75%, specificity 68%); total anaerobic microflora above 0.55% (sensitivity 71%, specificity 68%), Gardnerella vaginalis / Prevotella bivia / Porphyromonas spp. more than 0.08% (sensitivity 64.3%, specificity 73.7%) and Megasphaera spp. / Veilonella spp. / Dialister spp. more than 0.06% (sensitivity 66.7%, specificity 52.6%). If at least one of the above criteria was identified, the patient was attributed to the high risk group for PROM; when all four indicators of the distribution of microorganisms are taken into account, the sensitivity of the method was 85.5%, specificity was 68.4%, the predictive value of positive and negative diagnostic results (models accuracy) were 78.7%.

CONCLUSIONS: The most prognostically significant risk factors for the development of PROM in the study of the cervical microbiota are the number of Lactobacillus spp. less than 99.3%; Gardnerella vaginalis / Prevotella bivia / Porphyromonas spp. more than 0.08%; Megasphaera spp. / Veilonella spp. / Dialister spp. more than 0.06%.
Evaluation of the efficiency of treatment with the domestic drug “Promisan” of patients with cervical intraepithelial neoplasia grade I
Authors: Suleimanova Naida D. , Kharkhachaeva Saidat M.
Published: June 2022

BACKGROUND: At present cervical cancer (CC) is one of the most common malignancies in women. The prevention of cervical cancer is early diagnosis and timely treatment of precancerous processes, which include cervical intraepithelial neoplasia (CIN).

AIM: To evaluate the clinical efficacy of treatment of patients with CIN I with the use of domestic drug Promisan.

MATERIALS AND METHODS: A total of 58 patients with CIN I were studied. They were divided into 4 groups (group I and group II are the treatment groups, group III and group IV are control groups). Group I included 16 patients who received treatment with the drug Promisan in conservative treatment. Group II included 18 patients who received complex treatment consisting of radio-wave excision of the cervix followed by the administration of Promisan. Group III included 14 patients with expectant treatment (without Promisan) and Group IV included 10 patients who underwent radio-wave excision of the cervix with subsequent dynamic observation (without Promisan).

RESULTS: Improvement in the CIN regression indices of the 1st degree, improvement in colposcopic data and regression / elimination of the human papillomavirus were revealed in a greater percentage in patients who received Promisan as monotherapy and as part of complex therapy compared to the control groups.

CONCLUSIONS: The results of the study make it possible to recommend Promisan for the prevention of cervical cancer in patients with dysplastic processes.
Approaches to the pharmacotherapy of diabetic macular edema: Literature review
Authors: Ionkina Irina V. , Grinev Andrey G. , Zherebtsova Olga M.
Published: June 2022

Pharmacotherapy of diabetic retinopathy and diabetic macular edema can be subdivided into groups according to the class of drugs, the most important of which are vascular endothelial growth factor inhibitors and corticosteroids. Intravitreal administration of these drugs is more preferable. The systemic use of angiotensin and fibrate receptor blockers is of least importance. The use of eye drops of non-steroidal anti-inflammatory drugs does not have convincing evidence of the efficacy in the treatment of diabetic macular edema. The article presents the results of the main studies on the development of algorithms for the treatment of diabetic retinopathy and diabetic macular edema.
Retinal vein occlusion: Modern approaches to treatment
Authors: Kukharskaya Yulia I. , Ivanova Elena V. , Volodin Pavel L.
Published: June 2022

Retinal vein occlusion (RVO) is the most common retinal vascular disease, it ranks second in terms of severity of retinal damage and prognosis after diabetic retinopathy. The main cause of visual impairment in patients with RVO is the manifestation of macular edema (ME). Persistent ME may block the recovering of visual acuity. The development of new methods of diagnosis and treatment of this pathology has changed approaches to the management of patients with RVO. This review presents the advantages and promising treatment modalities of retinal venous occlusions, it also demonstrates their advantages and disadvantages. Administration of drug treatment in the therapy of RVO is advisable only in the acute period of the disease. Laser coagulation is still the standard treatment for neovascular complications associated with RVO. The necessity of surgical repair remains controversial, since its use can result in severe complications, such as damage to the central retinal artery, perforation of the eye, retinal detachment and traumatic neuropathy. The use of steroids for the treatment of ME is associated with their ability to reduce capillary permeability, however, there is high risk of cataract. Antiangiogenic therapy is effective against pathogenesis of ME in RVO and is a first-line treatment for this disorder. The use of subthreshold microimpulse laser treatment is promising. Possibilities of further improvement and use of combined techniques in the treatment of this pathology are considered.
Balloon microcompression of gasserian ganglion in treatment of patients with trigeminal neuralgia
Authors: Lazarchuk Dmitriy M. , Alekseev Gennadiy N. , Suslin Yuriy V. , Chernov Gleb N. , Chemidronov Sergey N.
Published: June 2022

AIM: To determine the group of patients with trigeminal neuralgia for whom the balloon microcompression is the optimal treatment modality. To evaluate the effectiveness of balloon microcompression in the treatment of patients with trigeminal neuralgia.

MATERIALS AND METHODS: The study included 52 patients (18 men and 34 women) with trigeminal neuralgia who were operated with the use of balloon microcompression in neurosurgical department of the Samara Regional Clinical Hospital named after V.D. Seredavin over the period from February 2012 to June 2017. The evaluation of effectiveness was carried by Visual Analogue Scale, Macnub scale, the dose tapering of anti-epileptic medicines was also taken into account.

RESULTS: In postoperative period the decrease in pain syndrome was noticed by 48 patients (92.3%) from 90 10 to 30 10 points by Visual Analogue Scale. According to Macnub scale 29 patients (55.7%) estimated the level of treatment as good. 19 patients (36.5%) had negative emotional response due to the hypoesthesia, so the result was estimated as satisfactory. 39 patients (75%) managed to decrease the dosage of Finlepsin from 1000-1200 mg to 300-400 mg. Among them there were 8 patients (15%) who subsequently discontinued taking Finlepsin.

CONCLUSIONS: Balloon microcompression of Gasserian ganglion is a destructive-symptomatic method that must be considered the main modality only in patients with idiopathic trigeminal neuralgia or with contraindications for operative treatment. Balloon microcompression of Gasserian ganglion is a minimally destructive treatment mode, which allows to increase the effectiveness of treatment due to the alleviation of pain paroxysm in the area of trigeminal innervation and the decrease in dosage of anti-epileptic medicine.
Low-intensity extracorporal shockwave therapy for Peyronie’s disease
Authors: Gubanov Evgeniy S. , Boryaev Evgeniy A. , Stolyarov Sergey A. , Zimichev Alexander A.
Published: June 2022

The article is devoted to the study of the effectiveness of low-intensity extracorporal shockwave therapy in the treatment of Peyronie disease. Fibroplastic induration of the penis, i.e Peyronie disease, is the one with poorly studied aetiology and pathogenesis. Treatment algorithm also needs to be studied. Literature review was performed. Examination and treatment of patients with the use of low-intensity extracorporeal shock wave therapy was performed. The results of our own research have confirmed the high efficiency and safety of the method.
Analysis of the stress-strain state of a digital model of a reconstructive lyophilized allogeneic bone implant with the change in its design features
Authors: Ippolitov Aleksey A. , Popov Nikolay V.
Published: June 2022

BACKGROUND: The favorable outcome after the restoration of bone loss in the jaws depends on many factors. Thus, one of the key factors is the data on the mechanical and biophysical characteristics of the used bone implants, ignorance of which often jeopardizes the successful treatment of dental patients.

AIM: To carry out a comparative experimental analysis of the stress-strain state of a digital model of a reconstructive lyophilized allogeneic bone implant with a change in its design characteristics.

MATERIALS AND METHODS: To determine the biomechanical indicators of integrity preservation, the analysis of the stress-strain state of mathematical models of a reconstructive cylindrical implant and a reconstructive implant made of lyophilized allogenic material was carried out under equal conditions using the finite element method.

RESULTS: As a result of the analysis of the stress-strain state of digital 3D models of reconstructive bone implants of two types, stress distributions according to von Mises (equivalent stresses) caused by the action of given loads were obtained. During the study, data on the margin of safety of reconstructive implants were obtained.

CONCLUSIONS: The capabilities of modern computer software make it possible to expand the possibilities of bone augmentation of the alveolar bone tissue of the jaws with simultaneous dental implantation, allowing analytically to find the optimal parameters of the used materials, to choose the magnitude and direction of force during their installation, and also to predict their behavior in the postoperative period.
Quantitative determination of anthracene derivatives in Aloe vera leaves: Technique development
Authors: Glushchenko Svetlana N. , Kurkin Vladimir A. , Shmygareva Anna A. , Sankov Anatoly N.
Published: June 2022

AIM: The purpose of this work is to develop and use the method for the quantitative determination of Aloe vera leaves (Aloe vera L. ex Webb) using UV spectrophotometry.

MATERIALS AND METHODS: Since the method of quantitative determination of Aloe vera leaves in the State Pharmacopoeia of the Russian Federation XIV edition is not available, it was developed at the Department of Pharmaceutical Economics and Management, Pharmaceutical Technology and Pharmacognozy of Orenburg State Medical University. According to this method the optimal conditions for the extraction of anthracene derivatives in aloe vera leaves are the following: extractant was 96% ethyl alcohol); the ratio of raw material and extractant was 1:10; extraction time was the extraction in a boiling water bath for 30 minutes and 15 minutes in an ultrasonic bath. The registration of the spectra was performed with the use of Unico 2800 spectrophotometer in the wavelength range of 190-700 nm in cuvettes with the layer thickness of 10 mm, Vilitec VBS ultrasonic bath. The UV spectra of water-alcohol and alkali-ammonia solutions of Aloe vera leaves were investigated.

RESULTS AND DISCUSSION: The quantification of the of anthracene derivatives (calculated on barbaloin) in Aloe vera leaves was carried out with the use of methodology that determines anthracene derivatives directly in the test solution without acid hydrolysis and oxidation of anthraglycosides. The developed method of quantitative analysis allowed to determine the content of the total anthracene derivatives in terms of barbaloin in fresh leaves of aloe vera, the content ranged from 3.0-5.0% (calculated on dry-air plant material).

CONCLUSIONS: It was found that the content of the total anthracene derivatives in Aloe vera leaves calculated on barbaloin is 3.33%.
Main trends in optimization of pharmaceutical care for underage customers
Authors: Kuryleva Margarita A. , Kirschina Irina A.
Published: June 2022

The article presents the results of assessing the pharmaceutical literacy of underage visitors of pharmacies and analyzing the professional activity of pharmaceutical workers when dealing with underage customers. Insufficient level of knowledge necessary for making meaningful purchases of medicines and other pharmaceutical products in underage customers was revealed. A sociological survey of pharmaceutical workers has shown that in most cases when children and adolescents come to pharmacy organizations, specialists are forced to contact their parents and / or other adults to clarify the necessary information about the purchased pharmaceutical products. The analysis has shown the need to adapt pharmaceutical counseling to the age characteristics of children and adolescents and the feasibility of pharmaceutical education in order to prevent pharmaceutical risks in this age group. The findings allowed to develop methodological approaches to the organization of pharmaceutical assistance for children and adolescents in pharmacy organizations, and organizational measures aimed at improving the pharmaceutical literacy of the younger generation from the point of view of pharmaceutical safety were identified.
Assessment of hygienic and periodontal status of patients after in-office tooth whitening
Authors: Magsumova Oksana A. , Postnikov Mikhail A. , Tkach Tatiana M. , Polkanova Victoria A.
Published: June 2022

Nowadays, an increasing number of dentists support non-invasive methods of treatment of dental discoloration, one of which is the in-office teeth whitening procedure. When treating teeth discoloration and taking into account the aesthetic wishes of the patient, correction of the hygienic state of the oral cavity is important. The study involved 123 people aged 18 to 35 years with sanitized oral cavity and no somatic pathologies. The patients were divided into 3 groups depending on the type of the used whitening system. To assess the hygienic state of the oral cavity, the OHI-S index (GreenVermillion) was used. The presence of the inflammatory process in the periodontal tissues and its intensity was checked using the gingival sulcus bleeding SBI index (MuhlemanSon). The indices were assessed 2 weeks before the office teeth whitening procedure, immediately before it, and 2 weeks, 6 and 12 months after the procedure. Teeth in-office whitening has a positive effect on oral hygiene. Good oral hygiene is noted both in the immediate and long-term follow-up, which is due to the high level of patient motivation. The study of the dynamics of the gingival bleeding index indicates the absence of the adverse effect of in-office teeth whitening on the condition of the periodontal soft tissues.
Study of the prevalence of anomalies of eruption of different groups of teeth in patients who have sought orthodontic care
Authors: Ishchenko Ekaterina A. , Popov Nikolay V.
Published: June 2022

BACKGROUND: Tooth impaction leads to many aesthetic and functional disorders and to the general deterioration in the quality of human life. Domestic and foreign scientists point at the increase in the number of medical consultations on this problem. Although the incidence of orthodontic care among patients with tooth impaction is extremely high, there is no consensus on the prevalence of impacted teeth.

AIM: To analyze the prevalence of dentition abnormality in various groups of patients who sought orthodontic care.

MATERIALS AND METHODS: The study was conducted at the clinical setting of the Department of Pediatric Dentistry and Orthodontics and the Department of Dentistry of IPE of Samara State Medical University in 2017-2020. A retrospective analysis of 423 medical records of orthodontic patients aged 18-32 years and a clinical examination of 134 dental patients aged 18-36 years were performed. A total of 557 patients were examined, including 236 women and 321 men.

RESULTS: A retrospective analysis of 423 case histories revealed impaction of 104 teeth of 72 patients (17.02%). A clinical examination of 134 orthodontic patients aged 18-36 years was conducted, 15 patients (11.19%) showed impaction of 23 teeth.

CONCLUSIONS: In the retrospective analysis of the upper jaw, molars were the predominant impacted teeth of 20 patients (62.5%), and canines were the second most frequently impacted teeth of 7 patients (21.88%). In the lower jaw, molars were also the most frequently impacted teeth in 59 patients (81.94%), and premolars occupied the second place among the most frequently impacted teeth in 8 patients (11.12%). Clinical examination of 134 orthodontic patients aged 18-36 years showed that 15 patients (11.19%) had impaction of 23 teeth. The majority of the impacted teeth were molars of the upper jaw (56,52%), and of the lower jaw (85,71). The second most frequently impacted teeth were maxillary canine teeth (26,09%) and mandibular canine teeth (14,29%).
Сylindrical dental implant positioning devices
Authors: Ivashchenko Aleksandr V. , Yablokov Aleksey E. , Vinnik Sergey V. , Tlustenko Valentina P. , Shestun Elena M.
Published: June 2022

Modern digital technologies and their software open up new possibilities in dentistry. For example, the use of computed tomography is becoming more and more affordable. Almost every dental tomograph has the necessary software for 3D planning of dental procedures. Dental implantation has developed significantly in our country. The available surgical equipment make it possible to put dental implants even with the deficit of bone tissue. The purpose of this article was to summarize various methods to plan the placing the dental implant and to manufacture surgical templates. Dentistry has always been closely associated with other areas of science and industry, it tends to use a large number of modern innovations and developments. In this article, we have collected materials to demonstrate how the treatment process is changing in response to the integration of computer diagnostics and manufacturing (CAD / CAM) technologies. Consequently, we have more efficient and less traumatic dental implant planning systems based on the accurate data and computer calculations that minimize technological and human negative factors.
Increasing the efficiency of diagnostics of periodontal tissue diseases with modern research method
Authors: Vinnik Anastasia V. , Postnikov Mikhail A. , Lyamin Artem V. , Tkach Tatyana M. , Vinnik Sergey V.
Published: June 2022

Nowadays periodontal tissue diseases remain the leading dental pathology. Healthy periodontium is revealed only in 12% of people, while the rest have lesions of varying severity: from initial inflammatory to severe destructive changes with loss of teeth. Severe periodontitis, leading to the loss of teeth, is found in 5-15% of cases. To diagnose and prescribe treatment, laboratory assessment of the content of the gingival groove and / or periodontal pocket was studied. We assessed the titer of the aerobic and anaerobic microorganisms in the samples, the greatr amount was in a clinically significant titer. Although there are various instruments for taking the contents of the gingival groove and / or periodontal pocket, they have a number of drawbacks which complicate the culturing of the material and distort the findings. Taking into account the advantages and disadvantages of the existing instruments, we have developed the instrument for collecting the content of the gingival groove.
Prevalence of non-cavitated and manifest forms of caries in preschool children in Samara
Authors: Rozakova Lyutsiya Sh.
Published: June 2022

Indices of the registration and evaluation of the severity of caries are useful tools in the estimation of both dental health among the population and the preventive dental programs advanced to the dentistry. The decay-missing-filled (DMF) index proposed by WHO in 1938 assumes the presence / absence of cavitated carious lesions of dentin, fillings and teeth extracted because of caries and its complications. A significant limitation of this indicator is the neglect of non-cavitated forms of caries, which make up 90 % of the pool of dental carious lesions. The purpose of the study was to assess the prevalence of non-cavitated and manifest forms of caries in preschool children in Samara. An epidemiological examination of the dental health of 4-8 years old children attending preschool and school educational institutions in Samara was performed. Totally 460 children were examined, of which 53 children (21 boys) were examined at the age of 4, 78 children (37 boys) at the age of 5, 178 (97 boys) at 6 years old, 78 (43 boys) at 7 years old, 73 (33 boys) at the age of 8 years. Two indices were used to assess the hard tissue damage caused by caries: the index of DMF of teeth and surfaces and the index of D0DMF of teeth and surfaces, the latter was proposed by the author. Our epidemiological study showed that the prevalence of dental caries in preschool children in Samara was 52.83%, 65.38%, 82.02%, 87.18%, 79.45% among 4, 5-, 6 -, 7- and 8-year-old children respectively. The prevalence of caries, taking into account non-cavitated forms, was 84.61%, 88.46%, 91.57%, 97.44% and 90.41% among 4, 5, 6, 7 and 8 year old children respectively. By the age of 8, 67.12% of children in Samara have permanent teeth with signs of developing caries (types without cavities). It suggests the necessity to start comprehensive programs for the prevention of caries in organized groups of children.