bluuebunny/crossref_metadata_2025 huggingface dataset:
Performing Image, Isobel Harbison (2019)
Authors: Sandström Frida
Published: October 2020

Review of: Performing Image, Isobel Harbison (2019)

Cambridge, MA: MIT Press, 256 pp.,

ISBN 978-0-26203-921-5, h/bk, £32.00
Using comics and graphic novels in K-9 education: An integrative research review
Authors: Wallner Lars , Barajas Katarina Eriksson
Published: October 2020

The aim of this article is to increase knowledge on the use of comics as materials in K-9 education (ages 6–15). This is achieved through an integrative research review. Reference lists and websites have been searched, both by database searches and manually, and the results analysed and cross-referenced to identify common areas of research and possible gaps in knowledge. 55 texts (research articles and doctoral theses) were found, with 40 first authors from fourteen countries. The results revealed several gaps in knowledge. Most of the analysed studies had been carried out in North America, which suggests that more studies in other educational contexts, published in English, are needed, and that cross-national studies of comics in education will be productive. Furthermore, only three of the analysed texts describe studies that have high ecological validity, while all of the remaining 52 studies were ‘staged’ studies, in which the researcher had introduced material and observed the results. This suggests that further studies that utilize non-experimental research methods are needed. Finally, most studies focus on students’ reading preferences in regard to comics, rather than, for example, on how students compose comics or what they learn through comics. Thus, further studies that explore student work with comics, and examine the kinds of knowledge that reading comics enables, are desirable.
Caticorns and Derp Warz: Exploring children’s literacy worlds through the production of comics
Authors: Jones Helen
Published: October 2020

This article examines how an after-school comics club made a space for children’s literacy practices. 21 8- to 10-year-olds took part in the ten-week project. During that time the children made their own comic strips, and worked in groups to create their own self-initiated publications. These comics were sold at two comics fairs, which were collaboratively planned and organized. In this article the multimodal medium of comics will be explored. The concept of children’s literacy worlds will be discussed in relation to identity. Text World Theory will be examined as a framework for analysing children’s literacy worlds, with a particular focus on the bidirectional relationship between the discourse world and the text world. Action Research as a methodology is considered. Text World Theory is then used to interrogate the literacy worlds of two groups of children, examining the interplay of the discourse world and the text world of the two comics created. The article argues that the space for children to create their own, self-initiated narratives plays an important role in children’s meaning making and exploration of identity, through a bidirectional relationship between their discourse and text worlds. Finally, the article offers suggestions for future practice.
‘Maybe I’ll make something with it’: Comics as alternative sex education
Authors: Boer Sam
Published: October 2020

This article discusses how the comics form is peculiarly suited to deliver affecting, inclusive sex education. Through analysing the comics anthologiesNot Your Mother’s Meatloaf, compiled by Saiya Miller and Liza Bley, andGraphic Reproduction, edited by Jenell Johnson as part of the Graphic Medicine series, this article addresses several specific ways in which these anthologies – and the autobiographical comics they include – demonstrate unconventional and effecting methods of conducting sex education. Comparing these collections to sex education film shows how comics are particularly suited to this goal. These comics anthologies demonstrate the importance of inclusive community-building as a central project of sex education, as well as the need to challenge the teacher–student methodology. Specific comics within these anthologies by Eli Brown and Paula Knight demonstrate how comics allow for radical expressions of how bodies relate to sex and sexuality. Other comics, including those by Alison Bechdel and Alex Barrett, reveal how the pauses and ambiguities fostered by comics heighten their emotional impact and educational value. The overarching power of these narrative comics comes from the self-awareness of the form itself, especially the vulnerability of drawing oneself in relation to sexual experiences. This article concludes that these distinct characteristics of comics allow both a healthy way for creators to look back on their own experiences with sex and, in turn, encourage readers to effectively learn from these depicted experiences.
Studying anti-Semitism using primary sources in graphic novels
Authors: Reingold Matt
Published: October 2020

Recent trends in history education have emphasized the study of primary sources as an important conduit for fostering critical and historical thinking skills and for allowing students to assume the role of historians. In the following article, I examine the ways that Nora Krug’s Belonging, Ari Folman and David Polonsky’s Anne Frank’s Diary and Will Eisner’s The Plot, all meaningfully engage with primary sources as a central feature of the graphic novel. Each of the texts addresses a different aspect of historical anti-Semitism but through the use of visual and textual devices that are woven into the primary sources, connections to contemporary society abound. Furthermore, what also emerges with these three texts is an active engagement with the reader wherein the primary sources are used to demand that the reader thinks about historical and contemporary anti-Semitism. Therefore, these three texts do not simply include primary sources but, like effective history educators, they model and foster critical and historical thinking through the visual and textual prompts. Their inclusion turns the reader into an active historian who participates in the process of discovery and arrives at their own understanding of the perniciousness of anti-Semitism throughout history and its continued presence in their own communities.
With Great Power Comes Great Pedagogy: Teaching, Learning, and Comics, Susan E. Kirtley, Antero Garcia and Peter E. Carlson (eds) (2020)
Authors: DeHart Jason D.
Published: October 2020

Review of: With Great Power Comes Great Pedagogy: Teaching, Learning, and Comics, Susan E. Kirtley, Antero Garcia and Peter E. Carlson (eds) (2020)

Jackson, MS: University Press of Mississippi, 270 pp.,

ISBN 978-1-49682-605-3, p/bk, $30
Lessons Drawn: Essays on the Pedagogy of Comics and Graphic Novels, David Seelow (2019)
Authors: Sinclair Megan
Published: October 2020

Review of: Lessons Drawn: Essays on the Pedagogy of Comics and Graphic Novels, David Seelow (2019)

Jefferson, MO: MacFarland, 186 pp.,

ISBN 978-1-47667-158-1, p/bk, £43.50
The combined effect of magnetic and electric fields using on/off infrared light on the blood sugar level and the diameter of Langerhans islets of diabetic mice
Authors: Suhariningsih S. , Astuti Suryani Dyah , Husen Saikhu Akhmad , Winarni Dwi , Rahmawati Dian Astri , Mukti Akhmad Taufiq , Putra Alfian Pramudita , Miftahussurur Muhammad
Published: October 2020

Background and Aim: At present, diabetes is treated with oral antidiabetic medicines, such as sulfonylureas and thiazolidine, as well as insulin injection. However, these methods have several shortcomings. Therefore, alternatives for treating diabetes mellitus (DM) are needed. This study aims to determine the combined effect of magnetic and electric fields on blood sugar levels and the diameter of Langerhans islets of diabetic mice.

Materials and Methods: Induction of DM in mice was carried out by administering lard for 2 weeks and continued with an intraperitoneal injection of streptozotocin, dissolved in a 4.5 pH citrate buffer, and administered in a dose of 30 mg/kg bodyweight for 5 days. Treatments were used in combination with magnetic and electric fields using on/off infrared light. Blood samples were pipetted through the tip of mice's tails to establish the blood sugar level for each individual mouse. Histology preparation of the pancreas organ was affected using the histology standard as well as hematoxylin and eosin staining methods. Langerhans islet diameter data were analyzed using analysis of variance followed by Duncan's multiple range test. Data analysis was performed at α=0.05.

Results: The results showed that the combined treatment of permanent magnetic and unidirectional electric fields (PS) caused changes in blood sugar levels that were not significantly different from the normal control group. The PS treatment improved the diameter of the Langerhans islets but not to a significant degree compared to other treatments.

Conclusion: The use of PS treatment is effective for reducing the blood sugar levels of diabetic mice and improving the diameter of their Langerhans islets.
Evaluation of the hematological and clinical biochemical markers of stress in broiler chickens
Authors: Nwaigwe Chioma U. , Ihedioha John I. , Shoyinka Shodeinde V. , Nwaigwe Chukwuemeka O.
Published: October 2020

Background and Aim: Stress significantly affects health and productivity of animals. There is need for affordable and easy-to-assay markers of physiological stress in broilers. This study evaluated hematological and serum biochemical markers of physiologic stress in broiler chickens.

Materials and Methods: Thirty day-old broiler chickens were assigned to three groups of ten broilers each during the 56-day study. Group 1 broilers served as the control and were not exposed to any stressors; Group 2 broilers were stocked at the stress density of 50 kg BW m–2 from day 49 to 56 while Group 3 broilers had their feed withdrawn 36 h before blood collection on day 56. Blood samples were collected on day 49 (pre-stress sample) and day 56 (post-stress sample) from all the birds and subjected to hematological and serum biochemical analysis.

Results: The parameters did not vary significantly (p>0.05) pre-stress. Post-stress, there were significant variations in the heterophil, lymphocyte, and eosinophil counts and in the heterophil to lymphocyte ratio across the three groups. The concentrations of the plasma fibrinogen and serum albumins, sodium, and sodium to potassium ratio of the broilers varied significantly across the groups.

Conclusion: Heterophil, eosinophil, and lymphocyte counts, the heterophil to lymphocyte ratio, plasma fibrinogen, serum albumin, sodium, and sodium to potassium ratio are significant markers of physiological stress in broilers.
A mesterpedagógus fokozat és a folyamatos szakmai fejlődés jellemzői óvodapedagógusok nézőpontjából
Authors: Kovacs Ivett Judit , Szivák Judit , Czachesz Erzsébet
Published: November 2020

A kutatás a pedagógus-előmeneteli rendszer mesterpedagógus fokozatának véglegesítését segítő pilot projekt keretében elkészített mesterpedagógus programok anyagait dolgozza fel az óvodapedagógusokra fókuszálva, illetve a megvalósult mesterprogramokhoz kötődő interjúkat elemzi. Olyan empirikus adatokat szolgáltat ezáltal a kora gyermekkori nevelés minőségét emelő tanári szakmai fejlődésről, melyek a munkavégzés helyén a kontextust, a szervezetet és az egyént egyaránt fókuszba helyezve vizsgálják a tervezést és annak megvalósulását. A kilencvenöt mesterprogram kvantitatív adatelemzése, majd kvalitatív dokumentumelemzése arra keresi a választ, hogy a pedagógus milyen terveket fogalmaz meg folyamatos szakmai fejlődésére vonatkozóan a mesterprogram öt évében. Mi inspirálja, milyen célokat tűz ki és milyen eredményekben gondolkodik a tervezett tanulási tevékenységek kapcsán, illetve hogyan kívánja tudását megosztani? A kutatás a programok elemzését követően félig strukturált interjúk módszerével tárja fel a tervezés hátterét, a megvalósítás sikereit és nehézségeit. A kvantitatív adatok, valamint a tizenkét mestertanárral készített interjú alapján a mestertanárok céljaiban jelentős hangsúly helyeződik a pedagógiai módszerek megújítására, valamint a megújuló pedagógiai módszerekhez és a változó jogszabályokhoz igazodó adminisztráció kidolgozására. Az interjúkban megszólaló pedagógusok megvilágították a minősítési rendszer sajátosságaiból következő kihívásokat és előnyöket, a mesterpedagógus szervezetben betöltött szerepét, valamint betekintést engedtek a pedagógusok minősüléssel kapcsolatos attitűdjébe. A kutatás empirikus eredményei fontos hozzájárulást jelentenek az óvodapedagógus-szakma és a kora gyermekkori intézményes nevelés hazai kutatása számára, elősegíthetik a minősítési rendszer továbbfejlesztését, valamint képet adnak a magyar óvodapedagógia helyzetéről és fejlesztési szándékairól a mesterpedagógusok nézőpontján keresztül.
A Efetividade do Controle Social a partir dos Portais Governamentais / The Effectiveness of Social Control from Governmental Portals
Authors: Sousa Alana De Oliveira , Amurim Aldir Dias de , Soares Amanda Paulino , Custódio Izabel Mônica Costa Silva
Published: October 2020

Resumo: A Administração Pública age com a finalidade de atender as necessidades básicas da população, como saúde, segurança e educação, promovendo assim o bem estar da sociedade. Para atender essas necessidades são promovidas políticas públicas que são custeadas pelo recolhimento de tributos cobrados a todos os contribuintes. A pesquisa tem como objetivo identificar as ferramentas de controle social mais utilizadas e o que compreende cada uma delas, a explanação da legislação pertinente à transparência pública, além da percepção dos servidores públicos quanto a efetividade do controle social. O trabalho possui abordagem quantitativa descritiva, mediante questionário acerca da avaliação de mecanismos que levam ao exercício do controle social. Verificou-se que, os entrevistados consideram importante os portais de transparência governamental para a efetividade do controle social, mas há uma dificuldade atrelada às informações que constam nesses portais, seja pela difícil compreensão, ou por não conseguirem encontrar as informações buscadas. Palavras-chave: Controle Social. Fiscalização. Portais Governamentais.
Adopting High Fat Diets for Fat Loss and Improving Brain Health.
Authors: Nashte Vaishnavi , Shinde Rutuja
Published: November 2020

With an increased intake of processed carbohydrates and refined sugars, the obesity rate has shot up in the past decade giving rise to mental and physical health problems. These individuals are also the most vulnerable to a number of other diseases including the current pandemic of Covid-19. This paper aims to address the knowledge gap that is required to promote a healthy lifestyle for mental and physical wellbeing. The paper also analyses a number of different studies conducted and helps in understanding obesity as a strong risk factor to various disorders. Despite constant recommendations from healthcare organisations to address the importance of weight regulation, the process to do so often remains uncertain to the general population. The paper analyses the effects of the ketogenic diet for fat loss as well as treating mental illnesses and aims to address the influence of high carbohydrate diets on mental illnesses.
A Real-World Promising Result of Endoscopic Full-Thickness Resection: It's Time for Endoscopic Full-Thickness Resection to Be Widely Used
Authors: Chu Yuan , Xu Meidong
Published: November 2020

During the past 2 decades, we have witnessed the rise and prevalence of endoscopic resection. Endoscopic full-thickness resection (EFTR) is a key technique in dealing with some difficult gastrointestinal lesions that are not eligible for conventional endoscopic mucosal resection or endoscopic submucosal dissection. However, EFTR is demanding with respect to endoscopic resection experience and defects closure skills, which limits its widespread use in clinical practice. Full-thickness resection device simplifies the operation and makes EFTR easier to master, even in low-level medical institutions. As the high-level evidence accumulates and technique improves, it's time for EFTR to be accepted and used by more and more endoscopists.
Types de formants dans la dérivation fonctionnelle polonaise et roumaine : bases théoriques
Authors: Czarnecki Szymon
Published: November 2020

The paper describes types of derivational formatives in Polish and Romanian functional, i.e. synchronic derivation, focusing on the proper derivation (i.e. derivation from single-word bases). The proper derivation is positioned as a type of word-formation and a branch of morphology. The author identifies theprimary functions of derivational formatives: the semantic, pragmatic and syntactic function. The formatives are identified using a methodology developed in Polish word-formation theory, especially within nest derivatology. Applying a methodology developed for the description of the Polish word-formationsystem is aimed at distinguishing derivational formatives in Romanian. The author identifies and classifies the following types of derivational formatives in Romanian: affixes (among these prefixes, suffixes, postfixes and ambifixes), alternants (defined as members of alternation), negative formatives (in backformation), paradigmatic formatives (defined as changes in inflexional paradigm), zero formative and accentual formatives. The author also suggests including the types of word-formation stems in the description of the formal structure of derivatives.
Taking A Long-Term Approach to the Development of Weightlifting Ability in Young Athletes
Authors: Morris Stephanie J. , Oliver Jon L. , Pedley Jason S. , Haff G. Gregory , Lloyd Rhodri S.
Published: November 2020

Despite previous misconceptions, youth participation in weightlifting is now recognized as safe and beneficial when delivered, programed, and monitored by a qualified professional. This article explores teaching progressions to help coaches periodize weightlifting training for young or novice athletes, with consideration to the theoretical concepts underpinning long-term athletic development. It is hoped that the structured and progressive guidelines presented in the current article will help coaches develop the weightlifting performance of their young athletes in a safe and effective manner.
Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects
Authors: Chen Hong-Ru , Chen Ching-Wen , Mandhani Nandita , Short-Miller Jonah C. , Smucker Marchelle R. , Sun Yu-Yo , Kuan Chia-Yi
Published: October 2020

Growing evidence suggests that early-life interactions among genetic, immune, and environment factors may modulate neurodevelopment and cause psycho-cognitive deficits. Maternal immune activation (MIA) induces autism-like behaviors in offspring, but how it interplays with perinatal brain injury (especially birth asphyxia or hypoxia ischemia [HI]) is unclear. Herein we compared the effects of MIA (injection of poly[I:C] to dam at gestational day 12.5), HI at postnatal day 10, and the combined MIA/HI insult in murine offspring of both sexes. We found that MIA induced autistic-like behaviors without microglial activation but amplified post-HI NFκB signaling, pro-inflammatory responses, and brain injury in offspring. Conversely, HI neither provoked autistic-like behaviors nor concealed them in the MIA offspring. Instead, the dual MIA/HI insult added autistic-like behaviors with diminished synaptic density and reduction of autism-related PSD-95 and Homer-1 in the hippocampus, which were missing in the singular MIA or HI insult. Further, the dual MIA/HI insult enhanced the brain influx of Otx2-positive monocytes that are associated with an increase of perineuronal net-enwrapped parvalbumin neurons. UsingCCR2-CreERmice to distinguish monocytes from the resident microglia, we found that the monocytic infiltrates gradually adopted a ramified morphology and expressed the microglial signature genes (Tmem119, P2RY12, and Sall1) in post-MIA/HI brains, with some continuing to express the proinflammatory cytokine TNFα. Finally, genetic or pharmacological obstruction of monocytic influx significantly reduced perineuronal net-enwrapped parvalbumin neurons and autistic-like behaviors in MIA/HI offspring. Together, these results suggest a pathologic role of monocytes in the two-hit (immune plus neonatal HI) model of neurodevelopmental defects.

SIGNIFICANCE STATEMENTIn autism spectrum disorders (ASDs), prenatal infection or maternal immune activation (MIA) may act as a primer for multiple genetic and environmental factors to impair neurodevelopment. This study examined whether MIA cooperates with neonatal cerebral hypoxia ischemia to promote ASD-like aberrations in mice using a novel two-hit model. It was shown that the combination of MIA and neonatal hypoxia ischemia produces autistic-like behaviors in the offspring, and has synergistic effects in inducing neuroinflammation, monocytic infiltrates, synaptic defects, and perineuronal nets. Furthermore, genetic or pharmacological intervention of the MCP1-CCR2 chemoattractant pathway markedly reduced monocytic infiltrates, perineuronal nets, and autistic-like behaviors. These results suggest reciprocal escalation of immune and neonatal brain injury in a subset of ASD that may benefit from monocyte-targeted treatments.
Educational media psychology: Methodological foundations of an integrated model
Authors:   Irkutsk State University, Skorova Larisa Vladimirovna , Kyshtymova Irina Mikhailovna ,   Irkutsk State University
Published: October 2020

Introduction. The article presents a model of educational media psychology. It is considered as a branch of educational psychology which focuses on processes of education and development within media environments. The research problem is determined by the controversy between new tasks of educational psychology associated with the transformation of the modern educational environment into a media environment and the lack of an integrated approach to fulfill them. The purpose of the study is to substantiate the new branch of educational psychology, to identify its problems, clarify its notions, and to describe its concepts and methodological foundations. Materials and Methods. The research employs methods of theoretical analysis and modeling. Results. The study suggests that educational media environment as an object of psychology is characterized by distinctive features which require systematic integration of disciplinary, methodological and instrumental approaches to research. At the disciplinary level, research investigations in the field of educational media psychology involve the integration of basic concepts of educational psychology and media psychology. At the interdisciplinary level, studies on educational media psychology deal with integration of approaches and methods of psychology, philosophy, linguistics, text theory, sociology and cultural studies, which are significant for conducting a psychological analysis of the media text as a mediator of educational processes. The study reveals the need for a multidisciplinary paradigm of integration of (1) activity theory, which is traditional for educational psychology, with ideas of discursive psychology, psychosemiotics, narrative psychology and psychoanalysis; (2) explanatory and complex approaches to the analysis of research objects; (3) quantitative and qualitative research methods. Conclusions. Educational media psychology is presented as an integrated model, which comprises objects and interconnected approaches (paradigmatic and disciplinary).
On I. A. Bunin’s Story The Date and the Dedication to “M. P. Ch.”
Authors: Ivanova Natalia
Published: November 2020

This article publishes a little-known story by I. A. Bunin in 1902 – The Date – with the dedication “M. P. CH.”, stored in the personal archive of Maria Pavlovna Chekhov. An attempt is made to trace the author’s changes in the story to 1907, which made it possible to remove the dedication and change the original title to Happiness. This edit did not suit Bunin; in Paris he once again changes the text of the story, giving a different name – Dawn All Night. Not only is the text of the story Happiness based on the 1907 collection Korabli, but the place of its publication is specified.
History is Human Destinies
Authors: Brio Valentine
Published: November 2020

Профессор Елена Петровна Червинскене (Elena Červinskienė), руководившая кафедрой Русской литературы Вильнюсского университета с 1984 по 1989 г., – автор ряда исследований, посвященных русской классической литературе, среди которых книги о Федоре Достоевском (Dostojevskis, 1971), Антоне Чехове (Единство художественного мира: А. П. Чехов, 1976), Льве Толстом (Levo Tolstojaus meno pasaulyje, 1978; По закону Льва Толстого, 1992), хрестоматии по русской эстетической и критической мысли Apie literatūros esmę: XVIII–XIX a. rusų estetinė ir kritinė mintis (1988), статьи и выступления о творчестве Михаила Салтыкова-Щедрина, Николая Некрасова, Ивана Тургенева, Александра Герцена, Афанасия Фета. Но среди многочисленных работ одна ее книга стоит совершенно особняком.

В июне 1941 г. Е. П. Червинскене оказалась среди тех 17 500–18 000 жителей Литвы, которые были депортированы в Сибирь или другие места ссылки. Об этой трагической части своей жизни Червинскене рассказала в книге воспоминаний Silpnųjų jėga (Vilnius: Vaga, 1995), которая четыре года спустя вышла и на русском языке (Сила слабых. Воспоминания. Пер. с лит. А. Кондюриной. Москва: Диалог-МГУ, 1999). В память о Е. П. Червинскене мы публикуем рецензию В. Брио на эту книгу. Рецензия появилась в одной из газет Литвы сразу после выхода мемуаров на литовском языке.
Nanochemical, nanostructural and biocolloidal aspects of transformations in dispersions of iron-aluminosilicate minerals
Authors:   F.D. Ovcharenko Institute of Biocolloid Chemistry of the NAS of Ukraine, Kovzun I.G. , Prokopenko V.A. ,   F.D. Ovcharenko Institute of Biocolloid Chemistry of the NAS of Ukraine, Panko A.V. ,   F.D. Ovcharenko Institute of Biocolloid Chemistry of the NAS of Ukraine, Tsyganovich O.A. ,   F.D. Ovcharenko Institute of Biocolloid Chemistry of the NAS of Ukraine, Oliinyk V.O. ,   F.D. Ovcharenko Institute of Biocolloid Chemistry of the NAS of Ukraine, Nikipelova O.M. ,   F.D. Ovcharenko Institute of Biocolloid Chemistry of the NAS of Ukraine, Ulberg Z.R. ,   F.D. Ovcharenko Institute of Biocolloid Chemistry of the NAS of Ukraine
Published: November 2020

It was considered the modern ideas of colloidal and biocolloidal nanoscience concerning complex transformational processes in widespread dispersions of iron-aluminosilicates. It was shown for the fi rst time that they infl uence on catastrophic phenomena in marine turbiditic-pelitic sediments and soils consisting of iron-aluminosilicates. Th e fundamental study results of nano- and microstructure transformations of disperse ironaluminosilicate compositions are presented. And it was established the possibilities of their application in: constructing of protective structures; balneology and medicine; metallurgy; development of the problem of saving the ecological balance in the sea hydrosphere; developing the new branch of science — biocolloidal marine geoecology.
EFFECT OF METAL IONS ON FUNCTIONING OF ANTIOXIDANT SYSTEM AND ENZYMES OF EXTRACELLULAR MATRIX IN TUMORS DIFFERED IN THEIR DOXORUBICIN SENSITIVITY
Authors:   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAN of Ukraine, Ukraine, Lozovska Yu.V. , Lukianova N.Yu. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAN of Ukraine, Ukraine, Andrusishуna І.М. ,   SI «Kundiiev Institute of Occupational Health, NAMN of Ukraine», Kyiv, Ukraine, Todor І.М. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAN of Ukraine, Ukraine, А.P. Burlaka A.P. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAN of Ukraine, Ukraine, Ganusevych І.І. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAN of Ukraine, Ukraine, Chekhun V.F. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAN of Ukraine, Ukraine
Published: November 2020

The content of the essential macro- and microelements (MaE and ME) – copper, zinc, magnesium, iron and calcium was measured in blood plasma (BP) and tumor tissue (TT) of the animals engrafted with Walker 256 carcinosarcoma (tumor strains sensitive or resistant to doxorubicin). Also, the link between the content of these elements and the functional state of metal-containing enzymes of antioxidant system (metallothionein-1 – MT-1, ceruloplasmin – CP, ferritin – FR, myeloperoxidase – MPO, transferrin – TF) as well proteolytic enzymes (matrix metalloproteinases – MMP-2 and -9) was studied. In BP of animals engrafted with either sensitive or resistant to doxorubicin carcinosarcoma Cu/Zn and Ca/Mg ratios increase 2.8-fold and 1.4-fold, respectively as compared to the intact animals. The differences between MaE and ME content in the animals with tumors differed in doxorubicin sensitivity as compared to the intact animals affected the indices of prooxidant-antioxidant system: 2.7 and 1.6-fold increase of MT-1 (for sensitive and resistant tumors, correspondingly), 1.2 and 1.6-fold increase of CP, and 4.6- and 9-fold increase of FR against 5 and 7.5-fold decrease of MPO and 1.3 and 1.9-fold decrease in TF. In TT of the animals engrafted with the resistant strain 1.7-fold decrease of MT-1, 65-fold increase of FR, and 2.5-fold increase of TF was evident as compared with TT of animals engrafted with the sensitive strain. The change in prooxidant-antioxidant balance in tumorbearing animals was accompanied by the increased proteolytic activity of the enzymes involved in remodeling extracellular matrix, MMP-2 and MMP-8. Increased copper and iron content in BP and TT of the animals with doxorubicinresistant Walker 256 carcinosarcoma could initiate of freeradical compounds generation and enhancement of MMP-2 and MMP-9 activation. Therefore, the ionic misbalance might be the cause of changes of the antioxidant system functions contributing to the formation of the resistant phenotype of neoplasms. This provides the rationale for the use of chelating agents for increasing sensitivity of resistant neoplasms to cytostatics.
Aktivitas Antioksidan Ekstrak Etanol Kamboja Jepang (Adenium obesum) dan Kamboja Putih (Plumeria acuminata)
Authors: Shofi Muh. , Suwitasari Fera , Istiqomah Nurul
Published: October 2020

AbstrakSenyawa antioksidan adalah senyawa yang dapat menangkal dampak radikal bebas dengan cara menghambat stres oksidatif serta menghentikan kerusakan sel dan induksi penyakit. Tanaman kamboja jepang (Adenium obesum) dan kamboja putih (Plumeria acuminata) termasuk tanaman hias yang memiliki khasiat obat. Tanaman ini banyak mengandung senyawa flavonoid dan senyawa antioksidan alami. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol daun dan bunga tanaman kamboja jepang dan kamboja putih. Ekstrak kamboja diperoleh dengan melakukan maserasi daun dan bunga kamboja dengan menggunakan pelarut etanol 70% dan 96%. Ekstrak kental daun dan bunga kamboja diperoleh dengan cara pemekatan ekstrak menggunakan penangas air. Uji skrining fitokimia ekstrak kental berupa kandungan alkaloid, saponin, tanin, flavonoid, terpenoid, dan steroid secara kualitatif, sementara aktivitas antioksidan diuji dengan metode 2,2-diphenyl-1-picrylhydrazyl (DPPH). Hasil skrining fitokimia ekstrak menunjukkan adanya kandungan alkaloid, tanin, flavonoid, dan saponin dengan nilai IC50 tertinggi ditunjukan oleh ekstrak bunga kamboja putih yang diekstrak dengan etanol 70% yaitu sebesar 98,41 ppm, dan terendah oleh bunga kamboja putih yang diekstrak dengan etanol 96% yaitu 533,13 ppm. Ekstrak etanol tanaman kamboja jepang dan kamboja putih memiliki potensi sebagai antioksidan alami.Abstract Antioxidant compounds are compounds that can counteract the effects of free radicals by inhibiting oxidative stress and stopping cell damage and disease induction. Japanese frangipani plants (Adenium obesum) And white frangipani (Plumeria acuminata), including ornamental plants that have medicinal properties. This plant contains a lot of flavonoid compounds and natural antioxidant compounds. This study aims to determine the antioxidant activity of ethanol extracts of leaves and flowers of japanese frangipani plants  and white frangipani. Frangipani extract is obtained by moderating frangipani leaves and flowers by using 70% and 96% ethanol solvents. Thick extracts of frangipani leaves and flowers are obtained by concentrating the extract using a water bath. Phytochemical screening tests of thick extracts containing alkaloids, saponins, tannins, flavonoids, terpenoids, and steroids qualitatively, while antioxidant activity was tested by the method 2,2-diphenyl-1-picrylhydrazyl (DPPH). Phytochemical screening results showed the presence of alkaloids, tannins, flavonoids, and saponins with the highest IC50 values shown by white frangipani extract extracted with 70% ethanol at 98.41 ppm, and the lowest by white frangipani extracted with 96% ethanol at 533.13 ppm. Ethanol extract of japanese frangipani and white frangipani plants have potential as natural antioxidants.
Potential of Cibodas Botanical Garden Fern and Lycophytes Collection as the Source of Medicine
Authors: Nikmatullah Muhamad , Rwnjana Elga , Muhaimin Muhamad , Rahayu Mulyati
Published: October 2020

AbstrakKebun Raya Cibodas (KRC) merupakan kawasan konservasi tumbuhan secara ex-situ yang berfokus untuk mengkonservasi tumbuhan dataran tinggi basah, mencakup tumbuhan langka dan tumbuhan bermanfaat.  Salah satu koleksi penting KRC adalah koleksi tumbuhan paku yang telah diketahui memiliki beragam manfaat, seperti sumber obat. Akan tetapi, potensinya sebagai sumber obat belum pernah dikaji lebih lanjut. Penelitian ini bertujuan untuk melakukan inventarisasi dan analisis terhadap koleksi tumbuhan paku KRC yang bernilai obat berdasarkan kajian literatur yang terkait dengan etnomedisin. Berdasarkan hasil kajian, sebanyak 38 jenis dari 29 marga dan 22 suku dari koleksi tumbuhan paku KRC telah diketahui manfaatnya sebagai obat. Suku Athyriaceae memiliki perwakilan jenis paling banyak yang memiliki khasiat obat, yaitu lima jenis. Terdapat 20 jenis koleksi tumbuhan paku KRC paling umum digunakan sebagai obat penutup luka dan penyakit akibat infeksi parasit. Daun dari 18 jenis merupakan bagian yang paling sering digunakan untuk pengobatan. Koleksi tumbuhan paku KRC berpotensi besar untuk dikembangkan sebagai sumber obat di masa mendatang. Berbagai upaya perlu dilakukan untuk mengembangkan potensi tersebut, antara lain perbanyakan koleksi dan uji aktivitas farmakologi senyawa aktif.Abstract Cibodas Botanical Garden (CBG) is an ex-situ plant conservation area that focuses on the conservation of mountain wet plants, including rare and useful plants. One of the important collections of CBG is ferns and lycophytes which have various benefits, such as a medicinal source. However, its potential as a medicinal source has not been studied further. This study aims to conduct an inventory and analysis of CBG’s ferns and lycophytes collection that have medicinal potential based on literature related to ethnomedicin. The results showed that CBG has 38 species, 29 genera, and 22 families of ferns and lycophytes collection that have known as medicine. The Athyriaceae group has the most representative species of medicinal properties, which are about five species. There are 20 species of CBG’s ferns and lycophytes collection were most commonly found as medicine for wounds and infectious diseases. The leaves from 18 species of ferns and lycophytes collection are most frequently used for disease medication. The CBG’s ferns and lycophytes collection has great potential to be developed as medicinal sources in the future. Various efforts are needed to develop the potential of ferns and lycophytes collection, such as increasing collections and studying the pharmacological activity of their active compounds.
Novel fenofibrate adverse effect in resistant hypertension: A case report
Authors: Barrouq Deena M. S. , Irshaidat Tareq
Published: October 2020

Background: Silent uncontrolled hypertension can cause major organ damage.

Case presentation: A 42-year-old hypertensive male used fenofibrate to lower his triglyceride levels; however, the investigation revealed that it caused a significant increase in the desire and ingestion of greasy food items which caused fluctuating high blood pressure. Correction of the dietary regimen and a modification in the usual recommended drug dose led to a significant positive development of the medical case. Specifically, it was successful in adjusting the systolic and diastolic blood pressure components and blood test parameters, and was effective in correcting the glucose criteria back to the acceptable standard range.

Conclusion: This is the first evidence in the literature on a poorly controlled hypertension case associated indirectly with fenofibrate.
Clinical decision-making approaches by health caregivers of patients with COVID-19
Authors: Taghadosi Mohsen , Ajorpaz Neda Mirbagher , Aghajani Mohammad
Published: October 2020

The Coronavirus disease of 2019 COVID-19) is the current health crisis in the world- a new, complex phenomenon that has affected and hospitalized many people around the world. Health care providers deal with COVID-19 patients daily and care for the patients while there is no definitive cure for it. Clinical decision-making is an important task of health professionals that plays an essential role in preserving the patient's life and providing quality care. Therefore, understanding clinical decision-making approaches by healthcare providers, such as nurses and physicians, especially in crises such as COVID-19, is essential.
Kidney damage by COVID-19 and rationale for extracorporeal therapies
Authors: Mehreen Uzma , Ali Ashiq , Khatoon Aisha , Zafar Nishat , Tanveer Qaisar , Basit Irha
Published: October 2020

Without doubt, there is some involvement of the kidney in novel coronavirus disease (COVID-19), which is responsible for multiple organ dysfunctions resulting in severe complications in the human body. This newly discovered COVID-19 has incited panic globally. However, the role of kidney involvement in the novel COVID-19 disease is still unclear. In this commentary, we discuss the various pathways involved in kidney damage by COVID-19, and the rationale for extracorporeal support with various blood purification strategies in critically ill people with COVID 19.
Relational Factors in Pragmatic Skill Development: Deaf and Hard of Hearing Infants and Toddlers
Authors: Mood Deborah , Szarkowski Amy , Brice Patrick J. , Wiley Susan
Published: November 2020

In this article, we review relational factors in early childhood believed to contribute in unique ways to pragmatic skill development in deaf and hard of hearing (DHH) infants and toddlers. These factors include attending to infant interactions with caregivers and others, supporting development of theory of mind through play and use of mental state language (ie, describing one’s own or others’ thoughts, feelings, and beliefs), and providing accessible opportunities for social interaction. On the basis of a review of the literature and clinical experience, we offer prescriptive strategies for supporting DHH children’s development in these areas. To improve outcomes for DHH children, medical care providers and allied health professionals have a responsibility to support the development of young DHH children’s pragmatic abilities by understanding these variables, coaching caregivers regarding their importance, and facilitating referrals for support when necessary.
Polycoccum Hawksworthianum (Polycoccaceae, Trypetheliales), A New Lichenicolous Fungus on Lepra and Varicellaria from India
Authors: Joshi Y.
Published: October 2020

The study revealed a new species of Polucoccum colonising thallus of lichen genus Lepra and Varicellaria in tropical and temperate regions of India. The genus belonging to the family Polycoccaceae is represented by 7 species in India. Though the genus is host-specific, there are 12 genera of lichens which are home for more than one species of this fungus. It is the second known species of Polucoccum on members of Lepra and Varicellaria, and differs from the previously known ones – 1) Polucoccum ochvarianum by being gall forming and having smaller perithecia [(88-)104-128-152(−170) × (81-)95-114-133(−145) μm] and 2) Polucoccum sp. in having smaller perithecia [op. cit. vs. 250-300 μm], hymenial gelatine I-, and smaller asci [(50-)55-60-65(-75) × (10-)13-15-17(-18) vs. 90 × 14 μim].
Development of EEG measurement and processing system in LabVIEW development environment
Authors: Barsy Bence Gergő , Győri Gyula , Szemes Péter Tamás
Published: October 2020

Our research team has developed a system and methodology for measuring psycho-physiological parameters, which can be used to determine the level of fatigue and fitness of the person being measured. This article describes the electroencephalography (EEG) part of this system. This article covers the technical and mathematical background of EEG measurement, the selection and implementation of the measurement tool in the development environment, and the development of the measurement and processing algorithm. The result is a system that can detect, digitize, and process the digitized signal from the brain, and save the processed signal in an XML database.
male body and Catholic piety in early modern Spain
Authors: Rhodes Elizabeth
Published: October 2020

Features of embodied female piety adduced from late medieval texts are now established categories of interpretation for religious experience in the early modern period. These include intense Eucharistic devotion in relationship to food culture, extreme food manipulation and exaggerated violence against the physical self. However, evidence from documents by and about early modern religious men indicates that male and female ascetic piety had more in common than not during this period. Strategies of backgrounding or masking those practices when carried out by men made them less visible in comparison to those practised by women, due to gender inflections in religious politics.
The Handbook of Technology and Second Language Teaching and Learning, edited by Carol A. Chapelle and Shannon Sauro
Authors: Di Mauro-Jackson Moira
Published: October 2020

The Handbook of Technology and Second Language Teaching and Learning

Edited by Carol A. Chapelle and Shannon Sauro

Hoboken, NJ: Wiley Blackwell

US $195.00

ISBN 9781118914038 (Hardcover)

520 pages

2017
Maternal and Fetal Outcomes of Pregnancies in Women with Atypical Hemolytic Uremic Syndrome
Authors: Gaggl Martina , Aigner Christof , Csuka Dorottya , Szilágyi Ágnes , Prohászka Zoltán , Kain Renate , Haninger Natalja , Knechtelsdorfer Maarten , Sunder-Plassmann Raute , Sunder-Plassmann Gere , Schmidt Alice
Published: October 2020

Atypical HUS (aHUS) is a disorder most commonly caused by inherited defects of the alternative pathway of complement, or the proteins that regulate this pathway, and life-threatening episodes of aHUS can be provoked by pregnancy. We retrospectively and prospectively investigated 27 maternal and fetal pregnancy outcomes in 14 women with aHUS from the Vienna Thrombotic Microangiopathy Cohort. Seven pregnancies (26%) were complicated by pregnancy-associated aHUS (p-aHUS), of which three appeared to be provoked by infection, bleeding, and curettage, and three individuals were considered to have preeclampsia/HELLP syndrome before the definitive diagnosis of p-aHUS was made. Mutations in genes that encode the complement alternative pathway proteins or the molecules that regulate this pathway were detected in 71% of the women, with no relationship to pregnancy outcome. Twenty-one pregnancies (78%) resulted in a live birth, two preterm infants were stillborn, and four pregnancies resulted in early spontaneous abortions. Although short-term renal outcome was good in most women, long-term renal outcome was poor; among the 14 women, four had CKD stage 1–4, five had received a renal allograft, and three were dialysis-dependent at study end. We prospectively followed nine pregnancies of four women and treated six of these pregnancies with prophylactic plasma infusions (one pregnancy resulted in p-aHUS, one intrauterine fetal death occurred, and seven pregancies were uneventful). Our study emphasizes the frequency of successful pregnancies in women with aHUS. Close monitoring of such pregnancies for episodes of thrombotic microangiopathy is essential but, the best strategy to prevent these episodes remains unclear.
Balık Tüketimi ve Öğrencilerin Okul Başarısı Arasındaki İlişkiler
Authors: EMRE Nesrin
Published: November 2020

Su ürünleri, hayvansal protein kaynağı olmakla beraber içerdiği zengin yağ, vitamin ve mineraller açısından önemli bir besin kaynağı olarak görülmektedir. Özellikle balığın önemli bir besin kaynağı olmasının yanı sıra, tüketiminin de akademik başarıya olan etkisi yapılan farklı çalışmalarla ortaya konulmuştur. Bu çalışmada, öğrencilerin balık tüketim sıklığı ile okul başarıları arasındaki ilişki farklı değişkenlerle ortaya çıkarılmıştır. Çalışmada betimsel tarama yöntemlerinden ilişkisel tarama deseni kullanılmıştır. Çalışmanın örneklemini Antalya İl Milli Eğitim Müdürlüğüne bağlı 2 ilköğretim ve 1 lise kurumundan sosyo-ekonomik düzeylerine göre rastgele seçilen 259 öğrenci oluşturmuştur. Çalışmada veri toplama aracı olarak araştırmacı tarafından geliştirilen bir anket kullanılmıştır. Elde edilen verilerin analizinde frekans, yüzde ve korelasyon değerlendirmeleri yapılmıştır. Araştırma sonucunda balık tüketimi ile akademik başarı arasındaki ilişki, öğrencilerin bağlı bulundukları okul, cinsiyet, sosyo-ekonomik düzey ve balık tüketim sıklıkları açısından ele alınmış olup, ulaşılan sonuçların kuramsal açıdan desteklendiği ancak istatistiki açıdan desteklenmediği sonuçlarına varılmıştır.
International Experience in Assessing and Analysing Labour Productivity Indicators at the National and Regional Levels
Authors:   Siberian Federal University (Krasnoyarsk, Russian Federation), Zimnyakova Tatyana S. , Samusenko Svetlana A. ,   Siberian Federal University (Krasnoyarsk, Russian Federation)
Published: October 2020

It is statistically proven that high labour productivity ensures the competitiveness of the territory, the level and quality of life of the population. Therefore, policy makers are taking measures aimed to improve labour productivity both on national and regional levels. This policy needs scientific justification, so methodological issues are becoming more acute every day. The article presents a critical analysis of international experience in evaluating and analysing labour productivity indicators. The methods are classified and described in the article; the advantages and disadvantages of the methods are identified. In addition, the article provides examples of the empirical application of these methods.
Use of Factors as Potential Components in the Portfolio Construction
Authors:   Vladimir State University (Vladimir, Russian Federation), Mishin Andrey A.
Published: October 2020

The article considers the application of factor investing in the formation of an investment portfolio. Five general factors (momentum, size, low volatility, value, quality), as well as the theory underlying them, are identified; their efficiency and cyclicality over time are shown; the potential benefits of investing in factor strategies are identified. The aim of the work was to provide a broad overview of factor investing as a framework that includes decision-making about impact factors in the portfolio formation process. The article concludes with the main provisions of factor investing.