bluuebunny/crossref_metadata_2025 huggingface dataset:
Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds
Authors: Cen Lu-Sha , Cao Yi , Zhou Yi-Mai , Guo Jing , Xue Jing-Wen
Published: November 2024

BACKGROUND

Shikonin is a natural remedy that is effective at treating diabetic wounds. NFAT5 is a potential therapeutic target for diabetes, and mitochondrial function is essential for wound healing. However, the relationship among Shikonin, NFAT5, and mitochondrial function has not been thoroughly studied. Here, we offer new perspectives on the advantages of shikonin for managing diabetes.

AIM

To assess the therapeutic mechanism of shikonin in diabetic wounds, its relationship with NFAT5, and its protection of mitochondrial function.

METHODS

Hypertonic cell and diabetic wound mouse models were established. NFAT5 expression was measured through western blotting and immunofluorescence, in vivo and in vitro . Mitochondrial function was evaluated using reactive oxygen species (ROS) detection and JC-1 and Calcein AM dyes. Mitochondrial structures were observed using transmission electron microscopy. The NFAT5/AMPK pathway was analyzed using a transfection vector and an inhibitor. The effect of shikonin on cells under hypertonic conditions via the NFAT5/AMPK pathway was assessed using western blotting.

RESULTS

Shikonin treatment preserved HaCaT cell viability, while significantly reducing cyclooxygenase-2 expression levels in a high-glucose environment (P < 0.05). Additionally, shikonin maintained mitochondrial morphology, enhanced membrane potential, reduced membrane permeability, and decreased ROS levels in HaCaT cells under hyperosmolar stress. Furthermore, shikonin promoted wound healing in diabetic mice (P < 0.05). Shikonin also inhibited NFAT5, in vivo and in vitro (P < 0.05). Shikonin treatment reduced NFAT5 expression levels, subsequently inhibiting AMPK expression in vitro (P < 0.05). Finally, shikonin inhibited several key downstream molecules of the NFAT5/AMPK pathway, including mammalian target of rapamycin, protein kinase B, nuclear factor kappa-light-chain-enhancer of activated B cells, and inducible nitric oxide synthase (P < 0.05).

CONCLUSION

Shikonin protects mitochondria via the NFAT5/AMPK-related pathway and enhances wound healing in diabetes.
Intestinal glucagon-like peptide-1 in hypoglycemic counterregulation for type 1 diabetes management
Authors: Zhang Ke-Xin , Kan Cheng-Xia , Wang Yu-Qun , Hou Ning-Ning , Sun Xiao-Dong
Published: November 2024

Type 1 diabetes (T1D) is characterized by the autoimmune destruction of pancreatic beta cells, leading to absolute insulin deficiency and the need for exogenous insulin. A significant concern in T1D management is hypoglycemia, which is worsened by impaired counterregulatory mechanisms. Effective counterregulation involves hormones such as glucagon and adrenaline, which work to restore normal blood glucose levels. However, in T1D, these mechanisms often fail, particularly after recurrent hypoglycemia, resulting in hypoglycemia-associated autonomic failure. Recent research indicates that elevated levels of intestinal glucagon-like peptide-1 (GLP-1) impair counterregulatory responses by reducing the secretion of glucagon and adrenaline. This editorial underscores GLP-1’s role beyond its incretin effects, contributing to impaired hypoglycemic counterregulation. This understanding necessitates a nuanced approach to GLP-1-based therapies in T1D, balancing the benefits of glycemic control with potential risks. Future research should delve into the mechanisms behind GLP-1’s effects and explore potential interventions to improve hypoglycemic counterregulation. The goal is to enhance the safety and quality of life for T1D patients.
Relevance of macrophages in the wound healing process among individuals afflicted with diabetic foot ulcers
Authors: Chen Li-Hong , Ran Xing-Wu
Published: November 2024

In this paper, we provide a commentary on an article focusing on diabetic foot ulcer (DFU) as a dreadful complication of diabetes mellitus. The development of this condition is influenced by factors such as diabetic peripheral neuropathy, lower extremity artery disease, and infection. However, the underlying mechanism remains elusive. Macrophages play a critical role in wound healing processes, suggesting that therapies targeting these cells could potentially improve the management of DFU. A comprehensive understanding of developmental trends of macrophages within the field of DFU may facilitate research advancements and the development of novel treatment strategies.
Insights into glymphatic system dysfunction and glucose continuum
Authors: Velikova Tsvetelina , Vasilev Georgi
Published: November 2024

In this article, we comment on an original article published in a recent issue of the World Journal of Diabetes . That observational cross-sectional study focused on investigating the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states by using diffusion tensor imaging along the perivascular space (DTI-ALPS) index. It was shown that the cerebral glymphatic system may be dysfunctional in patients with type 2 diabetes. Various clinical variables affected the DTI-ALPS index in different glucose metabolism states. In conclusion, the study by Tian et al improves the understanding of the pathophysiology of diabetes-associated brain damage and provides insights for early diagnosis.
Korczakowskie „prawo dziecka do szacunku” i wypowiadania swoich myśli w polskim postępowaniu cywilnym
Authors: Flaga-Gieruszyńska Kinga
Published: November 2024

Artykuł składa się z dwóch części. W pierwszej części, opartej na publikacjach pedagogicznych, omówiona została pedagogiczna działalność Janusza Korczaka jako prekursora i rzecznika praw dziecka. W części drugiej, opartej na publikacjach prawniczych, przedstawione zostały rozważania dotyczące praw dziecka i prawidłowego ich odzwierciedlenia, związanego z prawem dziecka do jego wysłuchania w sprawach cywilnych. Artykuł kończy się konkluzją o konieczności współpracy pedagogów z prawnikami w czasach, w których wzrasta świadomość potrzeby poszukiwania nowych rozwiązań prawnych, związanych z obecnością „dzieci bez dzieciństwa” i „dzieciństwa poza granicami”. Artykuł jest zapowiedzią kolejnych publikacji na ten temat.

Korczak’s “Right of a Child to Respect” and Expressing Their Thoughts in Polish Civil Procedure:

The article consists of two parts. The first part, based on pedagogical publications, discusses the pedagogical activity of Janusz Korczak as a precursor and advocate for children’s rights. The second part, based on legal publications, presents considerations concerning the rights of the child and their correct reflection, related to the child’s right to be heard in civil cases. The article ends with a conclusion about the necessity of cooperation between educators and lawyers at a time when there is a growing awareness of the need to look for new legal solutions related to the presence of “children without childhood” and “childhood beyond borders.” The article is a preview of further publications on this topic.
Dzieciństwo w okowach ideologii: kreacja dziecięcego świata na łamach czasopisma „Płomyczek” w latach 1948–1956
Authors: Król Joanna
Published: November 2024

Artykuł przedstawia rekonstrukcję i interpretację procesu kreacji dziecięcego świata oraz jego główne elementy na łamach czasopisma „Płomyczek” w latach 1948–1956. Dokonana analiza zawartości czasopisma przekonuje, że niemal każdy aspekt kreowanego świata dziecka odwołujący się do przestrzeni natury i kultury, mimo niezaprzeczalnego waloru edukacyjnego, zawierał również silny ładunek propagandowy. Treści, które autentycznie rozwijały stronę poznawczą, społeczno-moralną i emocjonalną odbiorcy przesycono warstwą ideologiczną, która odzwierciedlała ówczesny kierunek działań politycznych. Poprzez wpisanie w określony czas historyczny było to zatem czasopismo wyczerpujące model prasy komunistycznej (zwłaszcza w latach 1949–1953), która poprzez swoje cele, funkcje i treść odgrywała rolę pasa transmisyjnego dla przekazu ideologicznego. Propagandowy charakter zamieszczanych w „Płomyczku” treści zrodził z kolei pytanie, na ile efekt wspomnianego procesu odwoływał się do dziecięcego świata znaczeń, a na ile był odpowiedzią na doraźne potrzeby społeczno-polityczne.
La ineficacia en la reparación económica dentro de las acciones de protección en la provincia del Cañar en el periodo 2022
Authors: Espinoza Espinoza Erika Valeria , Zamora Vázquez Ana Fabiola
Published: November 2024

El presente trabajo estudió la ineficacia de la reparación económica dentro de las acciones de protección tramitadas en la provincia del Cañar en el periodo enero-diciembre 2022. Este trabajo se analizó desde un estudio autónomo de varios conceptos centrales que en este caso fueron las garantías jurisdiccionales, el derecho de protección judicial, la acción de protección y la reparación económica. Se revisó estos temas desde varios aspectos como: su trayectoria histórica, su importancia y su regulación en el derecho ecuatoriano vigente. Por último, se analizó detenidamente la ineficacia de la reparación económica dentro de las acciones de protección en el lugar y periodo de estudio, en el que se pudo identificar aspectos relevantes y su relación en cuanto al porcentaje en el incumplimiento de sus sentencias y su falta de celeridad. En este sentido, para cumplir con los objetivos propuestos, la investigación se realizó bajo una metodología de tipo no experimental, de corte transversal y de nivel descriptivo, con un enfoque mixto (cuantitativo-cualitativo), en los que se utilizaron los métodos histórico-lógico, inductivo-deductivo, analítico-sintético y dogmático. De igual manera, se utilizaron las técnicas de fichaje, revisión bibliográfica y documental de los procesos de acción de protección presentados en la provincia del Cañar durante el periodo de estudio. Como resultados se demostró la ineficacia de la reparación económica en esta garantía, lo que permitió concluir que el actual procedimiento para establecer la cuantificación no es el idóneo para garantizar al accionante un procedimiento expedito conforme la naturaleza y objeto de la acción de protección.
STRESS ANALYSIS OF CRANE SHACKLE USING FEM
Authors:   University of East Sarajevo, Faculty of Mechanical Engineering, Republic of Srpska, Bosnia and Herzegovina, Samardžić Srđan , Trifković Spasoje ,   University of East Sarajevo, Faculty of Mechanical Engineering, Republic of Srpska, Bosnia and Herzegovina, Milutinović Miroslav ,   University of East Sarajevo, Faculty of Mechanical Engineering, Republic of Srpska, Bosnia and Herzegovina
Published: November 2024

Shackle is a device used for lifting heavy loads by cranes. They can be closed type – forged shackles or articulated shackles. The weight of the shackle is the load that the crane always has to lift, which reduces the load capacity and increases the required lifting power. In order to reduce the required lifting power and increase the carrying capacity, it is necessary that the dimensions of the shackle have the minimum required value at the prescribed safety degree. This paper analyses the stress state of shackle analytically and numerically using the finite element method (FEM). At the end of the paper, a comparison of the obtained results is given.
ANALYSIS OF A RESIDENTIAL PHOTOVOLTAIC SYSTEM
Authors:   Aurel Vlaicu University of Arad, Romania, Petcuț-Lasc Anca-Adriana , Bălaș Valentina-Emilia ,   Aurel Vlaicu University of Arad, Romania, Petcuț Flavius-Maxim ,   Aurel Vlaicu University of Arad, Romania
Published: November 2024

This paper presents an analysis of residential photovoltaic (PV) panel systems, focusing on their environmental, economic and technological impact for homeowners. The study evaluates the financial viability of solar installations by examining energy savings and net metering. In addition, the environmental benefits of installing a residential PV, such as reduced carbon emissions and decreased reliance on non-renewable energy sources, are explored. The paper also assesses the technological advancements in solar panel efficiency, including monocrystalline, polycrystalline, and emerging bifacial and PERC technologies, to provide a detailed comparison of their performance in residential settings. Further, the integration of energy storage solutions and their potential to enhance energy independence and grid stability is discussed. Through a combination of the studied PV system this analysis points out the long-term advantages of the residential PV systems.
PRELIMINARY STUDY ON DRIVER POSTURE THROUGH NEW METHOD OF ANALYSIS
Authors:   Faculty of Mechanical Engineering, University Politehnica Timisoara, Timisoara, Romania, Sabău Anca , Popa Mihaela ,   Faculty of Engineering Hunedoara, University Politehnica Timisoara, Hunedoara, Romania, Stoia Gabriela ,   Faculty of Mechanical Engineering, University Politehnica Timisoara, Timisoara, Romania, Bacoș Timotei Bogdan ,   Faculty of Mechanical Engineering, University Politehnica Timisoara, Timisoara, Romania, Cioablă Adrian Eugen ,   Faculty of Mechanical Engineering, University Politehnica Timisoara, Timisoara, Romania
Published: November 2024

The driver position and posture during long activity hours can become a problem affecting overall health for speciffic activities relative to different jobs connected with driver applications. Current methods approach this aspect relative to obtaining results in different scenarios with applications on optimisation for driver posturality and overall short and long term benefits through added value of driver seat, activity and overall comfort. In this regard, the current paper aims to determine initial methods of analysis for driver posture in order to better determine solutions for optimising the overall ergonomic and confort aspects for drivers during long hour schedule.
The role of abandonment schema in the relationship between attachment styles and couple satisfaction
Authors:   University of Bucharest, Mihailov Ana
Published: November 2024

The present study aims to investigate the role of abandonment schema in the relationship between attachment styles and couple satisfaction. The design of the research is descriptive, cross-sectional and correlational. A total of 120 people participated, aged between 19 and 55 years, M = 25.67, AS = 8.95, 23 men and 97 women. Only people involved in a romantic relationship of at least six months participated. Data measurement was carried out using the questionnaire, made out of the Abandonment subscale of The Cognitive Style Questionnaire YSQ-S3, the Couple Satisfaction Index and the Attachment Style Questionnaire Short Form. The statistical results revealed the first hypothesis to be partially true, showing that secure attachment is positively associated with couple satisfaction. Regarding the second hypothesis, it was found to be partially true as well, as abandonment schema only mediates the relationships between anxious attachment and couple satisfaction and between dependent attachment and couple satisfaction. The results of the study are consistent with other research in the scientific literature and contribute to the completion of knowledge on the subject under investigation. Thus, it is proposed more future research on the subject in question.
Universal Design for Learning, Teachers’ Self-Efficacy, and School Performance in Inclusive Classrooms
Authors:   University of Bucharest, Piticari Petronela
Published: November 2024

The aim of this study is to investigate the extent to which teachers apply the principles of UDL in classroom context and the current conditions existing in schools for the implementation of these principles. The relationships between implementation of UDL principles, teachers' selfefficacy and students' school performance were also analyzed. A number of 151 teachers from Brașov county, aged between 21 and 63, M = 44.75, AS = 9.06 participated in the present study, of which 138 women (91%) and 13 men (9%). The implementation of UDL principles was measured through a list of specific UDL activities, organized into four categories (use of technology, diversified teaching, cooperative teaching, individualized assessment). Current conditions in schools were measured by means of a list of situations, organized into three categories (material resources, teachers' concern, modern applications). Selfefficacy was measured with General Self-Efficacy Scale, GSE (Schwarzer & Jerusalem, 1995). Students’ performance was measured by a computational algorithm. The results showed that teachers report high levels of application of UDL principles and that the main condition in schools that facilitate UDL is teachers' concern. Among the UDL principles, only the use of technology was positively associated with student performance, and among the current conditions in schools, only teachers' concern was positively associated with school performance. Teacher self-efficacy was positively associated with school performance and UDL principles. Practical implications are discussed and future research directions are established.
Transição energética e desenvolvimento no Brasil: análise da desigualdade regional no uso de sistemas de Micro e Minigeração Distribuída (MMGD)
Authors: Aransiola Temidayo James , Etulain Carlos Raul
Published: November 2024

A Lei 14.300 de janeiro de 2022 estabeleceu o marco legal para a produção de energia elétrica por meio da Microgeração e Minigeração Distribuída (MMGD) com o objetivo de promover a redução dos custos energéticos, tanto para domicílios e empresas, e acelerar a transição energética para fontes renováveis. Usando os dados municipais sobre MMGD fornecidos pela Empresa de Pesquisa Energética (EPE), de 2013 a 2022, este estudo mostra como essa medida legislativa gerou um crescimento notável na instalação e utilização de energia renovável no país, sobretudo proveniente de fonte solar fotovoltaica. Usando o índice de Gini, o estudo também mostrou que existe alta desigualdade regional de potência instalada e nível de investimento em MMGD. A partir dessas análises, este estudo discute os desafios de desenvolvimento decorrentes dessa Lei, considerando o contexto de aumento crescente das tarifas elétricas e as desigualdades estruturais existentes em nível residencial, setorial e regional.
Estudo de caso para aplicação de mecanismos de capacidade em um sistema de energia simplificado
Authors: Lehmkuhl Matheus , Reolon Scuzziato Murilo
Published: November 2024

Em mercados puramente energéticos podem ocorrer problemas no suprimento de energia por diferentes fatores. Para corrigir isso utilizam-se mecanismos de capacidade, com a contratação de usinas geradoras de energia para mitigar a probabilidade de déficit de potência e/ou energia do sistema. Assim, este trabalho tem como foco avaliar diferentes possibilidades de contratação de capacidade para o Sistema Interligado Nacional, utilizando um sistema com características físicas e regulatórias simplificadas. Como principais resultados tem-se um benefício sistêmico com a redução de risco do suprimento, no entanto, percebe-se um aumento dos custos para os consumidores na maioria das condições operativas, assim como um impacto financeiro considerável para os agentes participantes do Mecanismo de Realocação de Energia.
Estudo da qualidade da energia elétrica de inversores com duas topologias diferentes e desempenho energético de sistemas fotovoltaicos com distintos fatores de dimensionamento
Authors: May Max , Arns Rampinelli Giuliano
Published: November 2024

O aumento da demanda de energia evidencia a necessidade cada vez mais presente na busca por novas fontes energéticas, sobretudo fontes renováveis e com menor impacto ambiental. A energia solar fotovoltaica, tecnologia confiável, eficiente e com uma fonte abundante, ganha papel de destaque entre as novas fontes de energia. Nos últimos anos, o microinversor fotovoltaico, uma tecnologia já conhecida, porém ainda pouco difundida devido ao seu alto custo, passou a ganhar uma parcela significativa do mercado, disputando o espaço com inversores string. Porém, a escolha do inversor pode afetar diretamente o desempenho global dos sistemas fotovoltaicos, incluindo a qualidade da energia elétrica gerada e o desempenho do sistema. Assim, este artigo analisa a qualidade da energia elétrica gerada e o desempenho de sistemas fotovoltaicos conectados à rede elétrica de baixa tensão com inversores de distintas topologias e fatores de dimensionamento. Foram analisados três sistemas fotovoltaicos, localizados em diferentes localidades na região sul do Brasil. O Sistema FV 1 está instalado no telhado de uma edificação na cidade de Santa Rosa do Sul, Santa Catarina, o Sistema FV 2 está instalado no telhado de uma edificação na cidade de Alpestre, Rio Grande do Sul, e por fim o Sistema FV 3, que está instalado no telhado de uma planta piloto bioclimática no campus Araranguá da Universidade Federal de Santa Catarina (UFSC). Foram coletados dados utilizando um analisador da qualidade da energia elétrica, em diferentes períodos entre 2022 e 2023, para a análise das distorções harmônicas, e também dados de produção diária de energia elétrica, entre 2023 e 2024, obtidos diretamente dos sistemas de monitoramento dos inversores, para a análise do desempenho energético dos diferentes sistemas. Os resultados indicam que, em geral, os sistemas com inversores string (SF 1, SF2 e SF 3 (subsistema C)), mantiveram os níveis de distorção harmônica dentro dos limites normativos, enquanto o sistema com microinversor (subsistema D) apresentou maior variabilidade nos dados, especialmente em potências relativas baixas. Em termos de produtividade, os Sistemas FV 1, FV 2 e o subsistema C demonstraram índices de produtividade satisfatórios, com destaque para o subsistema C, que superou o subsistema D em 3,23%, considerando o mesmo período de análise. Conclui-se que a escolha da topologia do inversor e o fator de dimensionamento dos sistemas influenciam significativamente tanto a qualidade da energia elétrica quanto a produtividade do sistema, sendo, no estudo em análise, os inversores string mais estáveis em termos de qualidade de energia.
Especies vulnerables asociadas a la pesca con palangre de superficie en barcos nodrizas ecuatorianos
Authors: Zambrano René , Soriano Daniel , Duque Richard , Herrera Marco
Published: November 2024

El palangre de superficie es un arte pesca dirigido a la captura de peces pelágicos, el cual puede enganchar especies vulnerables como tiburones, tortugas, aves y mamíferos marinos. El objetivo del presente trabajo fue analizar la incidencia de estos grupos en la pesca de barcos nodrizas ecuatorianos. La base de datos fue proporcionada por el Instituto Público de Investigación de Acuicultura y Pesca, correspondiendo a registros de observadores a bordo, para el período 2019-2023. La principal carnada utilizada fue Dosidicus gigas. Se encontró el uso de anzuelos tipo “C” y “J”, siendo el segundo el más utilizado. Un total de 14 especies de tiburones, una de raya (Pteroplatytrygon violacea) y una de mantarraya (Mobula birostris) incidieron en la pesca con palangre. Prionace glauca, Alopias pelagicus, Carcharhinus falciformis, A. superciliosus e Isurus oxyrinchus tuvieron la incidencia anual más alta. La incidencia de tiburones mostró una baja relación con la cantidad de lances. Las aves marinas reportadas fueron 25 especies, alimentándose o deambulando. Oceanites gracilis y Procellaria parkinsoni tuvieron la mayor incidencia. Los delfines fueron los mamíferos marinos más representativos, el Género Delphinus fue el más abundante, sin evidencia de mortalidad. Las tortugas Chelonia mydas y Lepidochelys olivacea presentaron registros recurrentes, mientras que Caretta caretta y Dermochelys coriacea fueron esporádicas. Los tiburones fueron el único grupo que presentó mortalidad, mientras que, las tortugas presentaron lesiones corporales sin mortalidad. Bajo este escenario, es necesario desarrollar y aplicar medidas de manejo que promuevan la protección de las especies vulnerables.
Biotechnology and physical performance in sports "the mutants of the future"
Authors: Vanegas Castillo Javier Eduardo , Peña Ramirez William Alberto
Published: November 2024

There is great concern in the field of public health and sports ethics about how doping and gene doping are transforming athletes. This systematic review aims to analyze the current state of research on the contribution of biotechnology to sport and how this affects the health of athletes, bodybuilders, and high-intensity exercisers. The search includes articles published between 2014 and 2024; for this, databases without language restriction were used, finding 93 articles in the first search; finally, a total of 8 studies were selected in terms of the methodological process through the variables: biotechnology, sport, doping, and health. Studies on biotechnology and sports show that athletes continue to use substances to increase physical performance, and bodybuilders use them to improve size and aesthetic appearance.
Assessing the development of the attitudinal style as Pedagogical Model in Physical Education: a scoping review
Authors: Álvarez-Sánchez José Luis , Gutiérrez-García Carlos , Hortigüela-Alcalá David
Published: November 2024

The scoping review evaluates whether there is sufficient evidence to consider the Attitudinal Style as a pedagogical model in Physical Education. To this end, the review process assessed its strengths and weaknesses, and specific bibliography focused on the main divulgative, and research publications was selected. The study was conducted using the PRISMA-ScR extension (Tricco et al., 2018) by searching 10 bibliographic databases and grey literature to identify other studies on Attitudinal Style. Thus, a total of 102 publications were classified into three main categories: theoretical development (19.60%), practical development (73.58%), and research (6.82%). After a thorough analysis, the scoping study included the 26 most relevant articles, conducted between 2005 and 2023. Of these, eight articles presented evidence of the practical development of the model, 11 constituted the theoretical foundations, and seven focused on investigating its benefits. The selected bibliography confirms that the model meets almost all the criteria established by Chiva and Fernández-Río (2021) to be considered as a pedagogical model. Despite finding certain limitations, its strengths position it as a valuable methodological approach for future research, as well as for its implementation in various national and international educational contexts.
Marketing strategies to improve service quality at sports and fitness venues: a systematic review
Authors: Sadewa Yanuar Rachman , Sumaryanto Sumaryanto , Sumarjo Sumarjo
Published: November 2024

The sports and fitness industry has seen accelerated growth with increasing public awareness about the relevance of health and well-being. Nowadays, facilities such as gyms, stadiums, swimming pools and fitness centers have become essential elements of lifestyle in society. Marketing strategies are important to attract and retain customers. The programs offered should be viewed as service products that have sales value. Therefore, implementing effective marketing strategies is necessary to compete, satisfy customer needs and increase customer loyalty. This research aims to conduct a systematic review of existing literature regarding marketing strategies for sports and fitness venues using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method. This study includes research published in the last 10 years from indexed journal sources and identifies important findings regarding the effectiveness of various marketing strategies in service and retaining customers. The research results shows that personalization of service, utilization of technology, deep understanding of customer needs, and high service quality are key strategies that can increase perceived value, satisfaction, and customer loyalty in the sports and fitness sector.
Microservices Security Threat Modelling in DevOps Pipelines
Authors:   Software Developer, Avuthu Yogeswara Reddy
Published: November 2024

The rapid adoption of microservices architectures and DevOps pipelines has accelerated software delivery but introduced new security challenges. The decentralized nature of microservices, combined with the dynamic nature of DevOps workflows, increases the attack surface, making it essential to proactively identify and mitigate security threats. This paper presents a comprehensive threat modeling framework designed specifically for microservicesbased systems operating within CI/CD pipelines. By leveraging STRIDE and other threat mod- eling methodologies, we identify key vulnerabilities such as API exploitation, interservice communication risks, and dependency tampering. We also propose the integration of automated security tools, such as OWASP Threat Dragon and IriusRisk, to perform continuous threat modeling throughout the software development lifecycle. Additionally, this work explores the role of service meshes and mTLS protocols in securing microservices communication. A case study demonstrates the application of our framework in a real-world DevOps environment, highlighting how vulnerabilities can be identified and mitigated at different stages of the CI/CD pipeline. Our results indicate that automated threat modeling improves detection rates by 30% and reduces false positives, enhancing the overall security posture. This paper contributes to the growing body of knowledge on DevSecOps by providing actionable insights and best practices for integrating security into cloud-native microservices systems.
Current and Future Trends on Kipsigis Women Engagement on Social Economic Activities in Kericho and Bomet Counties, Kenya
Authors: Ngeny Elizabeth , Papa Marina
Published: November 2024

Purpose: Women continue to be essential contributors to both rural and urban economies all over the world. In this regard, Kipsigis women of Bomet and Kericho counties, living mainly in the rural areas, contribute to the well-being of their families and community, despite the traditional inhibitions imposed by culture, in terms of undertaking extra duties like leaving their homes in pursuance of entrepreneurship and self-transcendence. It is in this regard, that the current study on Kipsigis women roles and the effects of group socio-economic activities was proposed. The research objective sought to identify the current trends and postulate the future trends for women’s engagement in socio-economic activities.
Methodology: The study was looked at through a qualitative research method and an ethnographic research design, where different components of the study addressed the research problem. Various data collection methods were used: there were written questions in the open-ended questionnaire, oral questions in the focus group, observation and face to face interview questions. These questions were posed to the participants, who had been randomly picked to represent the rest of the population, with the view of collecting the data that was later analyzed. The study also potentially provided information that could contribute to increased investment in women’s socio-economic groups by the government as well as private sector, and can form the basis for further study to promote expansion of women socio-economic groups in the region.
Findings: The findings of the results as shown in the tables, indicate that perceptions of the youth and the public have changed in favor of the women actively participating in socio-economic activities since they have helped alleviate economic demands on the family and society. As was seen in the results, future economic trends of the Kipsigis women in the two counties, was promising, and that if women got the financial support to boost their group economic activities, they could achieve a lot, and they would succeed in supporting family and the society.
Unique Contribution to Theory, Practice and Policy: They would gain knowledge and expose themselves to how business is done, since they would be working as a group, and they would be able to increase the possibility of accessing financial resources. Some of the benefits of being in a group as up-coming entrepreneurs would be evidenced when they need to venture into business and would easily qualify for tenders from the different government agencies since one of the requirements is being in a group and the group has to be registered by the government under social services.
Role of Religious Education in Shaping Religious Moderation Awareness Among Students
Authors: Edi Ahyani
Published: November 2024

Religious education in higher education institutions plays a central role in shaping attitudes and awareness of religious moderation among students. This study aims to investigate the impact of mastery of religious education materials on the understanding of religious moderation and the role of teachers in shaping student perspectives. The research method uses a qualitative approach with interview techniques and content analysis. The research method uses a qualitative approach with interview techniques and content analysis. The research sample involved IAIN Ambon students from various study programs who participated in religious education courses with a total of 15 respondents. The results showed that religious education has a positive influence in shaping the awareness of religious moderation, especially through a deep understanding of the values of diversity and interfaith dialogue. The importance of teachers' role in supporting the learning process is evident in their ability to create a classroom environment that is open to diverse discussion and understanding. In addition, the study provides insight into teaching strategies that are effective in facilitating the development of attitudes toward religious moderation. The findings of this study have practical implications for the development of religious education curricula in universities, emphasizing the need for the integration of religious moderation values in every aspect of learning. As such, this research contributes to our understanding of how religious education can be a positive force in shaping attitudes toward religious moderation among college students.
Narratives of Religious Philosophy in the Massagala Tradition of the To Bentong Community of Barru South Sulawesi
Authors: Suryadi R Muhammad
Published: November 2024

This research aims to reveal the relationship created between society, culture, and religion in the life of the To Bentong community. This research also clarifies the growing understanding that generalizes To Bentong and To Balo as different and independent cultural identities. The qualitative research model with a descriptive-study approach in this research is used to unravel narratively descriptively the interplay of culture and religion demonstrated by the To Bentong community. This research refers to two data sources. Data obtained from interview techniques as primary sources and literature, books, and journals are used as secondary sources. The collected data were then analyzed critically and carefully. The results of the study found two things. First, Massagala as a tradition of the To Bentong community directly intersects and has similarities with Islamic teachings. The substance lies in the fasting ceremony held once every three years which usually lasts a week or a month. Second, Massagala gave birth to a value system or religious philosophy that guides the To Bentong community in relations, socialization, and communication, especially with the universe.
Towards an Archaeology of Visual Immersion. Reflections on the Screen in Wheatstones’s Stereoscope and Heilig’s Sensorama.
Authors:   Universidad Alberto Hurtado, Villalobos Henríquez Estefanía
Published: November 2024

When we refer to the idea of visual immersion, we imagine a displacement towards a virtual space in which we immerse ourselves and with which we interact. Proposals associated with immersion, such as the topic of travel, were already presented in advertising images of the early twentieth century. In this article, we will establish that these notions of immersion have been developed since the middle of the 18th century, specifically with the creation of the lenticular stereoscope in 1851. Using medial archaeology as a methodological approach, we will demonstrate that devices such as the stereoscope (18th century) and the Sensorama (20th century) not only transformed the form of visualization, but also offered immersive experiences that linked the viewer to both physical and virtual spaces.
Assessing the Influence of Participatory Communication on the Implementation of Special Economic Zone Projects
Authors: Owuondo Joseph
Published: November 2024

This study delves into the pivotal role of participatory communication in the establishment and prosperity of Special Economic Zones (SEZs), recognizing them as vital tools for economic growth and global industrialization. The research addresses a gap in the literature by focusing on the impact of participatory communication on SEZ performance, examining stakeholder engagement, knowledge transfer, and overall success. Drawing parallels with large-scale infrastructure projects and poverty alleviation, the study employs a comprehensive methodology, including literature review and content analysis. Key findings underscore the significance of participatory communication in stakeholder engagement, knowledge transferability, and strategic integration. The study concludes with policy recommendations emphasizing capacity building, knowledge transfer, clear guidelines, regular consultations, comprehensive communication strategies, and monitoring and evaluation mechanisms. Overall, the research significantly advances our understanding of the intricate dynamics of SEZs, underscoring the critical role of participatory communication in their success and advocating for further exploration in this evolving field.
REVOLUCIONANDO LA ENDODONCIA: LA IMPORTANCIA DE IRRIGANTES MÚLTIPLES PARA UNA DESINFECCIÓN EFECTIVA DEL SISTEMA DE CONDUCTOS RADICULARES UNA REVISIÓN NARRATIVA
Authors: Fernandez Calle Irving Pablo , Macias Limachi Edwin , Vargas Ticona Abigail Marisol , Aguilar Avalos Jenny Paula , Condori Escobar Marivel Irene , Maldonado Huaycho Alcides Ramber , Apaza Cayo Jenny Claudia , Espinoza Vega Miguel Angel , Marca Zeballos Jesús Alejandro , Apaza Acho Ivan Iver
Published: November 2024

La investigación titulada "Revolucionando la Endodoncia: La Importancia de Irrigantes Múltiples para una Desinfección Efectiva del Sistema de Conductos" presenta una revisión narrativa sobre la evolución y la relevancia de los irrigantes en el tratamiento endodóntico. Desde el uso de soluciones simples como agua y alcohol, hasta irrigantes avanzados como el hipoclorito de sodio, EDTA y nanopartículas, el estudio enfatiza la necesidad de combinaciones de irrigantes para mejorar la eficacia antimicrobiana y reducir las complicaciones asociadas a infecciones periradiculares. A través de una revisión exhaustiva de la literatura, se identifican vacíos en la investigación sobre la efectividad de las combinaciones de irrigantes en la eliminación de biofilms resistentes. Se discuten también las técnicas de activación como la irrigación ultrasónica, que optimizan la acción de los irrigantes. Entre los hallazgos destacados, se concluye que la aplicación secuencial de irrigantes permite maximizar su efectividad y que el uso de agua ozonizada y tiosulfato de sodio puede ofrecer alternativas prometedoras. El estudio subraya la necesidad de un enfoque integral en la irrigación endodóntica para lograr resultados clínicos óptimos y prevenir la reinfección post-tratamiento.
A Global Research Trend on Endolysosomal Calcium Two-Pore Channels via Bibliometric Analysis
Authors: Sediqi Nelofar , Jahidin Aisyah Hasyila , Hazizul  Hasan Mizaton
Published: November 2024

Two-pore channel (TPC) is an endolysosomal calcium channel implicated in numerous physiological processes and pathologies. Since no bibliometric studies have been conducted to evaluate the typical characteristics of TPC’s research, this study sought to pinpoint TPC’s global research trends and hotspots. The Scopus database was searched for TPC-related articles from 2000 to 2022. The data were analysed using Harzing’s Publish, Open Refine, and VOS viewer. In total, 292 TPC-related articles written in English were analysed. This study demonstrates that the publication rate of TPC has increased since their discovery in 2000 and will continue to increase until 2022. Over the past 22 years, research on TPC has focused on elucidating its function in calcium signalling, revealing its significance in a variety of physiological and pathological conditions. Yet, there are some research prospects for TPC that are currently understudied and warrant attention, notably in the context of autophagy, cancer, and COVID-19.
Mental Health Challenges among First Responders in India: A Bibliometric Review
Authors: Joseph Albin , P Jose Tony
Published: November 2024

First responders in critical care are the trained professionals who offer help at the time of an emergency event, trauma, disaster, accident or injury. As they are working in a stress prone environment, it is critical to ensure adequate psychological aids to cope with mental health challenges among them. The objective of this bibliometric analysis is to explore, map and evaluate the scientific literature related to the mental health of first responders in India in the past twenty years. A total of 424 published articles were extracted from the Scopus database in relation to the proposed study. The extracted data was then analysed by employing the comprehensive bibliometric analysis techniques by using the statistical software “R- Studio,” followed by VOS viewer software for mapping and visualization of results. Results revealed the annual growth of publications in the area, most contributing authors, institutions as well as journals. The results of the bibliometric analysis revealed the cumulative trend and nature of the scientific literature in the mental health domain of Indian first responders. The findings of this research can serve as a stepping stone for the future research endeavours related to the optimization of mental health and wellbeing of the first responder community not only in India but also around the globe.
The Caste Continuum: Intersectional Identities and Visual Metaphors in Geeli Pucchi (2021)
Authors: Prasitha V  , Bhuvaneswari G
Published: November 2024

In Indian society, the caste system and its social hierarchies result in the marginalization of certain communities, notably the Dalits. Within the Dalit community, Dalit women face greater discrimination as their caste and gender identities intersect and intensify their plight. Similarly, the entrenched gender binary system and the dominant heterosexuality marginalize the queer community people. This intersection of Dalit, women, and queer identity unveils the challenges faced by individuals who navigate these marginalized identities. Films have emerged as the voices of marginalized communities and have made an effort to incorporate Dalit Queer narratives, depicting the harsh realities unfolding in Indian society. The paper offers a critical reading of a Bollywood short film Geeli Pucchi (2021) directed by Neeraj Ghaywan, the third part of the Netflix web series (anthology) titled “Ajeeb Daastaans”. The select film portrays the complex interplay of caste, gender, and sexuality. The paper attempts to analyze the intersectional realities of caste in lesbian love and argues that caste as an identity is a prominent oppressor that intersects with other identities such as gender and sexuality, complicating the lived realities of an individual. The paper further explores the visual metaphors employed in the select film, revealing the pervasive influence of caste in our daily lives.
Are Women Poorer? Empirical Insights from Rural Odisha
Authors: Biswal Surya Narayan , Mishra Santosh Kumar , Sarangi Minaketan
Published: November 2024

The present study assesses the status and determinants of multidimensional poverty in eight blocks of Jagatsinghpur district. Five socio-economic dimensions comprising fifteen indicators have been considered to construct the Multidimensional Poverty Index, using the Alkire-Foster Method at the individual level. Assessment of multidimensional poverty at the block level and for women for the first time in Odisha justifies the study's novelty. The study revealed the skewed distribution of multidimensional poverty towards women. Women are more deprived in comparison to men in education, employment, asset ownership, possession of agricultural land, and organization of community-level activities. Variation in multidimensional poverty is also observed across eight blocks under study. Binomial logistic regression analysis indicates the significant negative effect of age, education, and occupation on multidimensional poverty. The findings of the study suggest not only the reorientation of government policies in increasing women’s educational level, employability skills, and appropriate self-employment opportunities through women's self-help groups but also their strict implementation to empower women and reduce multidimensional poverty.
Design and Fabrication of L and U Slot Wearable Antennas for Wireless Body Area Network Applications
Authors: Subramaniam Mahendrakumar , Chandrasekaran Gokul , Jayachandran T  , SR Malathi , Kumar Neelam Sanjeev , Krishnan Vanitha
Published: November 2024

Wearable microstrip patch antennas are compact, low-profile antennas designed for integration into wearable devices, offering wireless communication capabilities. Wireless body area networks (WBANs) are a promising technology with potential applications in a variety of biomedical fields. Patient surveillance, healthcare monitoring, and medical diagnostics are a few examples. The Specific Absorption Rate (SAR) in close proximity to the body, as well as the device's size, vulnerability to the environment, and limited bandwidth, all have an impact on its efficacy and dependability. This paper gives a thorough look at the planning, testing, and production of a wearable antenna that works at 2.4 GHz and has unique U-cut and double L-cut slots inside a patch antenna structure. The primary focus is on reducing specific absorption rate (SAR) exposure while maintaining optimal performance metrics. We rigorously analyze parameters such as SAR reduction, VSWR, return loss, radiation pattern, gain, and efficiency using the High Frequency Structural Simulator (HFSS). This SAR-aware wearable antenna design, which includes parameter analysis, addresses concerns about people being too close to electromagnetic radiation from wireless devices. We tested the fabricated antennas using a VNA testing instrument. Following the testing process, we conducted a comparison between the simulation and fabrication results. Upon comparison, we found that the antenna's software simulation and hardware testing results were identical. They both operated at 2.4 GHz and achieved a gain of 20 dB. This indicates a successful design and validation process for the fabricated antenna.