bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune-Related Adverse Events Due to Cancer Immunotherapy: Immune Mechanisms and Clinical Manifestations
Authors: Casagrande Silvia , Sopetto Giulia Boscato , Bertalot Giovanni , Bortolotti Roberto , Racanelli Vito , Caffo Orazio , Giometto Bruno , Berti Alvise , Veccia Antonello
Published: April 2024

The landscape of cancer treatment has undergone a significant transformation with the introduction of Immune Checkpoint Inhibitors (ICIs). Patients undergoing these treatments often report prolonged clinical and radiological responses, albeit with a potential risk of developing immune-related adverse events (irAEs). Here, we reviewed and discussed the mechanisms of action of ICIs and their pivotal role in regulating the immune system to enhance the anti-tumor immune response. We scrutinized the intricate pathogenic mechanisms responsible for irAEs, arising from the evasion of self-tolerance checkpoints due to drug-induced immune modulation. We also summarized the main clinical manifestations due to irAEs categorized by organ types, detailing their incidence and associated risk factors. The occurrence of irAEs is more frequent when ICIs are combined; with neurological, cardiovascular, hematological, and rheumatic irAEs more commonly linked to PD1/PD-L1 inhibitors and cutaneous and gastrointestinal irAEs more prevalent with CTLA4 inhibitors. Due to the often-nonspecific signs and symptoms, the diagnosis of irAEs (especially for those rare ones) can be challenging. The differential with primary autoimmune disorders becomes sometimes intricate, given the clinical and pathophysiological similarities. In conclusion, considering the escalating use of ICIs, this area of research necessitates additional clinical studies and practical insights, especially the development of biomarkers for predicting immune toxicities. In addition, there is a need for heightened education for both clinicians and patients to enhance understanding and awareness.
Performance of Commercial Dermatoscopic Systems That Incorporate Artificial Intelligence for the Identification of Melanoma in General Practice: A Systematic Review
Authors: Miller Ian , Rosic Nedeljka , Stapelberg Michael , Hudson Jeremy , Coxon Paul , Furness James , Walsh Joe , Climstein Mike
Published: April 2024

Background: Cutaneous melanoma remains an increasing global public health burden, particularly in fair-skinned populations. Advancing technologies, particularly artificial intelligence (AI), may provide an additional tool for clinicians to help detect malignancies with a more accurate success rate. This systematic review aimed to report the performance metrics of commercially available convolutional neural networks (CNNs) tasked with detecting MM. Methods: A systematic literature search was performed using CINAHL, Medline, Scopus, ScienceDirect and Web of Science databases. Results: A total of 16 articles reporting MM were included in this review. The combined number of melanomas detected was 1160, and non-melanoma lesions were 33,010. The performance of market-approved technology and clinician performance for classifying melanoma was highly heterogeneous, with sensitivity ranging from 16.4 to 100.0%, specificity between 40.0 and 98.3% and accuracy between 44.0 and 92.0%. Less heterogeneity was observed when clinicians worked in unison with AI, with sensitivity ranging between 83.3 and 100.0%, specificity between 83.7 and 87.3%, and accuracy between 86.4 and 86.9%. Conclusion: Instead of focusing on the performance of AI versus clinicians for classifying melanoma, more consistent performance has been obtained when clinicians’ work is supported by AI, facilitating management decisions and improving health outcomes.
One-Dimensional Tubular Carbon Nitride Embedded in Ni2P for Enhanced Photocatalytic Activity of H2 Evolution
Authors: Jiang Chenyong , Jiao Yiwei , Li Fada , Fang Cheng , Ding Jing , Wan Hui , Zhang Ping , Guan Guofeng
Published: April 2024

Graphitic carbon nitride is considered as an ideal semiconductor material for photocatalytic hydrogen evolution due to its suitable energy band structure, durability and environmental friendliness. To further improve the catalytic performance of g-C3N4, nickel phosphide-loaded one-dimensional tubular carbon nitride (Ni2P/TCN) was prepared by thermal polymerization and photo deposition. The beneficial effect of the one-dimensional tubular structure on hydrogen generation was mainly attributed to its larger specific surface area (increased light absorption) as well as the linear movement of the carriers, which reduced their diffusion distance to the surface and facilitated the separation of photogenerated carriers. The loading of Ni2P co-catalyst improved the visible light utilization efficiency and enabled the migration of photogenerated electrons towards Ni2P, which ultimately reacted with the enhanced adsorbed H+ on the Ni2P surface to facilitate the photocatalytic hydrogen evolution process. This study provides new clues for the further development of efficient, environmentally friendly and low-cost g-C3N4 catalysts.
A Green Nanocatalyst for Fatty Acid Methyl Ester Conversion from Waste Cooking Oil
Authors: Khosa Sadaf , Rani Madeeha , Saeed Muhammad , Ali Syed Danish , Alhodaib Aiyeshah , Waseem Amir
Published: April 2024

This study used a novel combination of cellulose nanocrystals (CNCs) and calcium oxide (CaO) nanocomposite (CaO/CNCs) for the production of biodiesel from waste cooking oil. The filter paper was used as a raw cellulose source to produce the CNCs from the acid hydrolysis of cellulose with sulfuric acid. The as-synthesized CaO/CNC nanocomposite is recyclable and environmentally friendly and was characterized using Fourier transform infrared spectroscopy, energy dispersive X-ray, scanning electron microscopy, and X-ray diffraction. The optimum process parameters investigated are a 20:1 methanol-to-oil molar ratio, 3-weight percent catalyst concentration, 60 °C temperature, and 90 min of reaction time. Under the optimum conditions, a biodiesel yield of 84% was obtained. The CaO/CNC nanocomposite achieved five times reusability, indicating its effectiveness and reusability in the transesterification reaction. The synthesized biodiesel chemical composition was examined using FTIR, GCMS, 1H-NMR, and 13C-NMR, and its properties, including specific gravity, color, flash point, cloud point, pour point, viscosity, sulfur content, sediments, water content, total acid number, cetane number, and corrosion test, were ascertained using ASTM standard practices. The outcomes were determined to fulfill global biodiesel standards (ASTM 951, 6751). Five successive transesterification processes were used to test the regeneration of the catalyst; the first three showed no distinct change, while the fifth cycle showed a reduction of up to 79%. The innovative composite CaO/CNC and used cooking oil are stable, affordable, and extremely successful for long-term biodiesel generation.
Three-Dimensional Electrode-Enhanced Ozone Catalytic Oxidation for Thiamethoxam Wastewater Treatment: Performance, Kinetics, and Pathway
Authors: Zhou Weijie , Xiao Jibo , Jiang Xiang , Su Jianchao , Chu Shuyi , Ma Xiao , Li Jun
Published: April 2024

Thiamethoxam is a second-generation neonicotinoid pesticide that is used worldwide. In this study, a three-dimensional electrode-enhanced ozone catalytic oxidation system (3DE-GAC-O3) was constructed to pretreat thiamethoxam wastewater, with granular active carbon as the particle electrode. The effects of catalytic oxidation time, current density, ozone concentration, initial thiamethoxam concentration, pH, and particle electrode dosage on thiamethoxam degradation were investigated. A response surface method based on the Box–Behnken design was employed to optimize the 3DE-GAC-O3 process. The results revealed that the 3DE-GAC-O3 system exhibited higher efficiency compared with the 3D electrode method, ozone catalytic oxidation, or 2DE-O3. The optimal operating conditions included a particle electrode dosage, ozone concentration, current density, solution pH, catalytic oxidation time, and initial thiamethoxam concentration of 18 g/dm3, 12 g/h, 25 A/m2, 7, 300 min, and 500 mg/dm3, respectively. The corresponding chemical oxygen demand removal rate reached 93.86 ± 0.95%. Thiamethoxam degradation followed a second-order reaction kinetics equation, and the rate constant decreased with increasing the initial thiamethoxam concentration. Free-radical quenching experiments indicated that both O2∙− and ∙OH were present within the 3DE-GAC-O3 system, with ∙OH being the predominant species. A GC-MS analysis revealed the formation of several intermediate products, which were characterized based on the mass fragmentation pattern. Additionally, a probable degradation pathway for thiamethoxam was proposed. Therefore, 3DE-GAC-O3 is an efficient method for the pretreatment of thiamethoxam wastewater.
Residual Cystine Transport Activity for Specific Infantile and Juvenile CTNS Mutations in a PTEC-Based Addback Model
Authors: Medaer Louise , David Dries , Smits Maxime , Levtchenko Elena , Sampaolesi Maurilio , Gijsbers Rik
Published: April 2024

Cystinosis is a rare, autosomal recessive, lysosomal storage disease caused by mutations in the gene CTNS, leading to cystine accumulation in the lysosomes. While cysteamine lowers the cystine levels, it does not cure the disease, suggesting that CTNS exerts additional functions besides cystine transport. This study investigated the impact of infantile and juvenile CTNS mutations with discrepant genotype/phenotype correlations on CTNS expression, and subcellular localisation and function in clinically relevant cystinosis cell models to better understand the link between genotype and CTNS function. Using CTNS-depleted proximal tubule epithelial cells and patient-derived fibroblasts, we expressed a selection of CTNSmutants under various promoters. EF1a-driven expression led to substantial overexpression, resulting in CTNS protein levels that localised to the lysosomal compartment. All CTNSmutants tested also reversed cystine accumulation, indicating that CTNSmutants still exert transport activity, possibly due to the overexpression conditions. Surprisingly, even CTNSmutants expression driven by the less potent CTNS and EFS promoters reversed the cystine accumulation, contrary to the CTNSG339R missense mutant. Taken together, our findings shed new light on CTNS mutations, highlighting the need for robust assessment methodologies in clinically relevant cellular models and thus paving the way for better stratification of cystinosis patients, and advocating for the development of more personalized therapy.
Mitochondrial Permeability Transition, Cell Death and Neurodegeneration
Authors: Baev Artyom Y. , Vinokurov Andrey Y. , Potapova Elena V. , Dunaev Andrey V. , Angelova Plamena R. , Abramov Andrey Y.
Published: April 2024

Neurodegenerative diseases are chronic conditions occurring when neurons die in specific brain regions that lead to loss of movement or cognitive functions. Despite the progress in understanding the mechanisms of this pathology, currently no cure exists to treat these types of diseases: for some of them the only help is alleviating the associated symptoms. Mitochondrial dysfunction has been shown to be involved in the pathogenesis of most the neurodegenerative disorders. The fast and transient permeability of mitochondria (the mitochondrial permeability transition, mPT) has been shown to be an initial step in the mechanism of apoptotic and necrotic cell death, which acts as a regulator of tissue regeneration for postmitotic neurons as it leads to the irreparable loss of cells and cell function. In this study, we review the role of the mitochondrial permeability transition in neuronal death in major neurodegenerative diseases, covering the inductors of mPTP opening in neurons, including the major ones—free radicals and calcium—and we discuss perspectives and difficulties in the development of a neuroprotective strategy based on the inhibition of mPTP in neurodegenerative disorders.
Interconnections between the Cation/Alkaline pH-Responsive Slt and the Ambient pH Response of PacC/Pal Pathways in Aspergillus nidulans
Authors: Picazo Irene , Espeso Eduardo A.
Published: April 2024

In the filamentous ascomycete Aspergillus nidulans, at least three high hierarchy transcription factors are required for growth at extracellular alkaline pH: SltA, PacC and CrzA. Transcriptomic profiles depending on alkaline pH and SltA function showed that pacC expression might be under SltA regulation. Additional transcriptional studies of PacC and the only pH-regulated pal gene, palF, confirmed both the strong dependence on ambient pH and the function of SltA. The regulation of pacC expression is dependent on the activity of the zinc binuclear (C6) cluster transcription factor PacX. However, we found that the ablation of sltA in the pacX− mutant background specifically prevents the increase in pacC expression levels without affecting PacC protein levels, showing a novel specific function of the PacX factor. The loss of sltA function causes the anomalous proteolytic processing of PacC and a reduction in the post-translational modifications of PalF. At alkaline pH, in a null sltA background, PacC72kDa accumulates, detection of the intermediate PacC53kDa form is extremely low and the final processed form of 27 kDa shows altered electrophoretic mobility. Constitutive ubiquitination of PalF or the presence of alkalinity-mimicking mutations in pacC, such as pacCc14 and pacCc700, resembling PacC53kDa and PacC27kDa, respectively, allowed the normal processing of PacC but did not rescue the alkaline pH-sensitive phenotype caused by the null sltA allele. Overall, data show that Slt and PacC/Pal pathways are interconnected, but the transcription factor SltA is on a higher hierarchical level than PacC on regulating the tolerance to the ambient alkalinity in A. nidulans.
Phthalocyanine and Porphyrin Derivatives and Their Hybrid Materials in Optical Sensors Based on the Phenomenon of Surface Plasmon Resonance
Authors: Basova Tamara
Published: April 2024

In this review, the state of research over the past fifteen years in the field of the applications of metal phthalocyanines and porphyrin derivatives as well as their hybrid materials with carbon nanotubes, metal oxides, and polymers in optical sensors based on the phenomenon of surface plasmon resonance (SPR) is analyzed. The first chapter of the review presents an analysis of works on the use of porphyrins and phthalocyanines in classical SPR sensors for the detection of gases and volatile organic vapors, as well as their improved modifications, such as total internal reflection ellipsometry (TIRE) and magneto-optical SPR (MOSPR) methods, while the second chapter is devoted to their application for the detection of various analytes in solutions. The third chapter of the review summarizes publications describing recent advances in the use of porous materials based on hybrids of carbon nanotubes and oxides with metal phthalocyanines. The fourth chapter describes two-dimensional metal-organic frameworks (MOFs) based on metal porphyrin derivatives as SPR sensitizers.
Final Validation of the Quality of Life after Brain Injury for Children and Adolescents (QOLIBRI-KID/ADO) Questionnaire
Authors: von Steinbuechel Nicole , Zeldovich Marina , Timmermann Dagmar , Krenz Ugne , Koerte Inga K. , Bonfert Michaela V. , Berweck Steffen , Kieslich Matthias , Henrich Marlene , Brockmann Knut , Buchheim Anna , Roediger Maike , Lendt Michael , Auer Christian , Neu Axel , Kaiser Alexander , Driemeyer Joenna , Greving Sven , Wartemann Ulrike , Pinggera Daniel , Thomé Claudius , Suss Joachim , Muehlan Holger , Cunitz Katrin
Published: April 2024

Until recently, no disease-specific health-related quality of life (HRQoL) questionnaire existed for pediatric traumatic brain injuries (TBIs). In this revalidation study, the psychometric properties and the validity of the 35-item QOLIBRI-KID/ADO questionnaire in its final German version were examined in 300 children and adolescents. It is the first self-reported TBI-specific tool for measuring pediatric HRQoL in individuals aged between 8 and 17 years. The six-factor model fits the data adequately. The questionnaire’s internal consistency was excellent for the total score and satisfactory to excellent for the scale scores. Intraclass correlations indicated good test–retest reliability, and the measure’s construct validity was supported by the overlap between the QOLBRI-KID/ADO and the PedsQL, which measures generic HRQoL. The discriminant validity tests showed that older children and girls reported a significantly lower HRQoL than comparison groups, and this was also true of children who were anxious or depressed, or who suffered from post-concussion symptoms, replicating the results of the questionnaire’s first developmental study. Our results suggest that the QOLIBRI-KID/ADO is a reliable and valid multidimensional tool that can be used together with the adult version in clinical contexts and research to measure disease-specific HRQoL after pediatric TBI throughout a person’s life. This may help improve care, treatment, daily functioning, and HRQoL after TBI.
Drowning and Nonfatal Drowning in Children and Adolescents: A Subsequent Retrospective Data Analysis
Authors: Berger Sebastian , Siekmeyer Manuela , Petzold-Quinque Stefanie , Kiess Wieland , Merkenschlager Andreas
Published: April 2024

Fatal and nonfatal drowning are among the leading causes of death and lifelong severe neurological impairment among children and adolescents. This study aimed to complement research from Leipzig 1994–2008 to seek trends within risk factors, treatments, and outcomes throughout the last decade. We retrospectively investigated data of 47 inpatients aged 0–18 admitted to Leipzig University Department of Pediatrics who matched ICD-10 code T75.1 from 2008 to 2020 and compared them to a preceding study at the same institution. We also examined the prognostic value of parameters regarding the patients’ outcomes. There were three median incidents per annum. The median age was 2.75 years; 76% of incidents happened in males. An accumulation was seen during the summer months and weekends. Most drowning incidents occurred in private ponds or pools (48.9%). Thirty-nine children were discharged without resulting morbidity, four showed neurological impairment, and three died. Risk factors concerning age, sex, and incident characteristics were confirmed. Special supervision needs still apply to 1–3-year-old male children or children with pre-existing health conditions around private pools and ponds. Hospitalization duration shortened, and morbidity and lethality decreased since the previous study. There was structural improvement in primary care and medical documentation. Parameters suggesting good outcomes include a submersion time < 5 min, GCS > 3 points, spontaneous movement upon admission, remaining pupillary light response, the absence of cardiovascular arrest, body temperature ≥ 32 °C, pH > 7, blood glucose < 15 mmol/L, lactate < 14 mmol/L, base excess ≥ −15 mmol/L, and the absence of ARDS. Clear legislation can contribute to improved private home water safety. Further studies should include a broad in- and outpatient spectrum and standardized incident documentation presupposing Utstein-style reporting. Regular reinvestigation of consistent geographical regions facilitates process evaluations of drowning epidemiology and therapy evolution.
Psychosocial Adjustment as a Mediator in the Relationship between Childhood Exposure to Maternal Depression and Subsequent BMI and Overweight Risk
Authors: Niu Lijie , Hanson Skylar , Preciado-Becerra Juanita , Eskandarani Abdulaziz , Lei Xiaomeng , Le Mi , Niu Zhongzheng , Xie Bin
Published: April 2024

Objectives: This study investigated the correlation between early exposure to maternal depression (from 1 month to Grade 3) and the body mass index (BMI) and potential for overweight in adolescents at age 15. It further examined if the pathway of this correlation was influenced by psychosocial adjustment during mid-childhood (Grade 3 to Grade 6), specifically through internalizing and externalizing behaviors. Methods: Our study utilized data from 844 participants in the NICHD Study of Early Child Care and Youth Development (SECCYD) to assess the effects of maternal depression, observed from when the children were one month old to Grade 3, on BMI and the likelihood of overweight or obesity in adolescents aged 15. We also explored whether the average scores of internalizing and externalizing behaviors between Grades 3 and 6 mediated the impact of early maternal depressive symptoms on subsequent health outcomes. The analysis was adjusted for demographic and socioeconomic factors. Results: Findings revealed that internalizing and externalizing behavioral issues significantly mediated the relationship between prolonged maternal depression exposure and subsequent BMI, as well as the risk of overweight or obesity, in adolescents at age 15. Notably, this mediating effect was predominantly evident in girls. Conclusions: Our research demonstrated that the correlation between prolonged exposure to maternal depressive symptoms in childhood and increased BMI and overweight risk in adolescence was significantly mediated through psychosocial adjustment behaviors. We advocate for further exploration of additional mediating factors in future studies.
Adaptation and Validation of the MapMe Body Image Scales in Spanish Parents of Schoolchildren
Authors: Inclan-Lopez Patricia , Martinez-Andres Maria , Jones Angela R. , Tovée Martin J. , Adamson Ashley J. , Bartolome-Gutierrez Raquel
Published: April 2024

Childhood overweight and obesity is a worldwide problem and to treat it parents’ detection has to be improved. The MapMe Body Image Scales (BIS) are a visual tool developed to improve parental perception of child weight in the United Kingdon (UK) based on British growth reference criteria. The aim of this study was to make a transcultural adaptation and validation of the MapMe BIS in Spain based on International Obesity Task Force (IOTF) cut offs A descriptive cross-sectional study was done. First, a translation and cultural adaptation was carried out. A total of 155 10–11-year-old children and their parents participated in this study. Children were measured to calculate their weight status, Body Mass Index (BMI), Body Fat Percentage (BFP) and Waist Circumference (WC), and their parents completed a purpose designed questionnaire about their perception and satisfaction of child’s body weight status using the adapted BIS. Test-retest reliability, criterion validity and concurrent validity of the adapted BIS were analyzed. This study shows that the adapted MapMe BIS has good psychometric properties and is a suitable visual scale to assess parental perception of weight status in 10 and 11-year-old children in Spain.
Blood Adhesion Molecules as Biomarkers in Children with Chronic Urticaria
Authors: Angeli Ioanna , Vassilopoulou Emilia , Cassimos Dimitrios , Fotopoulos Ioannis , Serbis Anastasios , Alexandros Makis , Tsabouri Sophia
Published: April 2024

Background: The prevailing etiological model of both acute and chronic urticaria implicates specific allergen exposure that triggers the local release of vasoactive factors and inflammatory adhesion molecules, including vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), endothelial leukocyte adhesion molecule 1 (ELAM-1), P-selectin and E-selectin in the superficial dermis. This study focused on the possible role of VCAM-1 and ICAM-1 as biomarkers in children with acute and chronic urticaria. Methods: This study involved 184 children, 40 with acute urticaria, 71 with chronic urticaria, and 73 matched comparison subjects. The serum levels of ICAM-1 and VCAM-1 were determined in venous blood in all the participants on enrollment. Antihistamine treatment was administered to all the patients. In the children with chronic urticaria, the Urticaria Activity Score Questionnaire (UAS7) was completed daily by the parents. In 16 of the patients with acute urticaria and 43 with chronic urticaria, the serum levels of ICAM-1 and VCAM-1 were determined at follow-up after 6–8 weeks of treatment. Results: The mean serum levels of both VCAM-1 and ICAM-1 were higher in both groups of children with urticaria than in the comparison subjects at the start of the study. In the chronic urticaria group, the levels decreased significantly (p = 0.03 and p = 0.01, respectively) following treatment. Similarly, the acute urticaria group exhibited significant reduction in the mean levels of VCAM and ICAM (p < 0.001). In both groups, the mean level of ICAM after treatment was comparable with that of the comparison group. Conclusions: VCAM-1 and ICAM-1 are suggested as promising biomarkers for monitoring both acute and chronic urticaria in children. Future research should explore their utility in larger cohorts and investigate their role in personalized treatment strategies.
Study on Nocturnal Infant Crying Evaluation (NICE) and Reflux Disease (RED)
Authors: Carabelli Greta , Binotto Ivan , Armano Chiara , Bertù Lorenza , Luini Chiara , Nosetti Luana , Agosti Massimo , Salvatore Silvia
Published: April 2024

Background: Nocturnal infant crying is often empirically treated with acid suppressants. The aim of this study was to evaluate the prevalence and characteristics of gastroesophageal reflux (GER) in infants with unexplained persistent crying. Methods: We enrolled all infants (0–12 months) referred for suspected GER disease who underwent esophageal impedance–pH monitoring (MII-pH) for unexplained persistent crying not improved by parental reassurance, dietary modification or alginate. Gastrointestinal malformation/surgery, neurological impairment and infections were exclusion criteria. Demographic and anthropometric parameters, GER symptoms and questionnaires (I-GERQ-R) and MII-pH data were recorded and analyzed. Normal MII-pH was defined when acid exposure was <3%, symptom index was <50% and symptom association probability was <95%. Acid exposure >5% and >10% was also considered. Statistical analysis was performed using Chi-Square and univariate and multivariable regression analysis. Results: We included 50 infants (median age 3.5 months) who fulfilled the study criteria: 30 (60%) had normal MII-pH. I-GERQ-R score was abnormal in 33 (66%) infants, and 21/33 (64%) had normal MII-pH (p = 0.47). In the 26 (52%) infants with nocturnal crying, MII-pH was normal in 16 (54%) (p = 0.82). Associated regurgitation (>3 or >10 episodes/die) did not predict abnormal MII-pH (p = 0.74, p = 0.82, respectively). Univariate and multivariable regression analysis did not identify any clinical variable significantly associated with abnormal MII-pH. Conclusions: Infants with persistent unexplained and nocturnal crying should not be empirically treated with acid inhibitors.
Meta-Analysis and Ranking of the Most Effective Methane Reduction Strategies for Australia’s Beef and Dairy Sector
Authors: Kelliher Merideth , Bogueva Diana , Marinova Dora
Published: April 2024

Although Australia remains committed to the Paris Agreement and to reducing its greenhouse gas emissions, it was late in joining the 2021 Global Methane Pledge. Finding suitable methane (CH4) mitigation solutions for Australia’s livestock industry should be part of this journey. Based on a 2020–2023 systematic literature review and multicriteria decision approach, this study analyses the available strategies for the Australian beef and dairy sector under three scenarios: baseline, where all assessment criteria are equally weighted; climate emergency, with a significant emphasis on CH4 reduction for cattle in pasture and feedlot systems; and conservative, where priority is given to reducing costs. In total, 46 strategies from 27 academic publications were identified and classified as ‘Avoid’, ‘Shift’, or ‘Improve’ with respect to their impact on current CH4 emissions. The findings indicate that ‘Avoid’ strategies of conversion of agricultural land to wetlands, salt marshes, and tidal forest are most efficient in the climate emergency scenario, while the ‘Improve’ strategy of including CH4 production in the cattle breeding goals is the best for the conservative and baseline scenarios. A policy mix that encourages a wide range of strategies is required to ensure CH4 emission reductions and make Australia’s livestock industry more sustainable.
Evaluation of the Fatigue Performance of Full-Depth Reclamation with Portland Cement Material Based on the Weibull Distribution Model
Authors: Li Yongxiang , Zhao Longwei , Gao Junfeng , Ru Yanyan , Zhang Haiwei
Published: April 2024

The full-depth reclamation with Portland cement (FDR-PC) technology embodies an environmentally friendly approach to solving the damage to old asphalt pavement. Fatigue failure emerges as the predominant mode of degradation for FDR-PC pavement. The fatigue characteristics of the full-depth reclamation with Portland cement cold recycled mixtures were evaluated through four-point bending tests. Three contents (4%, 5%, 6%) of cement and three base-to-surface ratios (10:0, 8:2, 6:4) were utilized. The fatigue equations were derived for the mixtures using a two-parameter Weibull distribution. The results indicate that all correlation coefficients of the Weibull distribution model surpass 0.88, effectively projecting the lifespan of FDR-PC. With increases in cement contents and base-to-surface ratios, the fatigue life of the mixture extends, though with an augmentation of stress sensitivity. Comparative analysis with the fatigue equation model parameters of the current Chinese specifications for the design of highway asphalt pavement reveals that mixtures with a 4% cement content and combinations of a 5% cement content with a low base-to-surface ratio meet the requirements for inorganic-binder-stabilized soil. Additionally, mixtures with a 5% cement content and a high base-to-surface ratio, along with those with a 6% cement content, fulfill the specifications for inorganic-binder-stabilized granular materials.
Analysis of Biometric-Based Cryptographic Key Exchange Protocols—BAKE and BRAKE
Authors: Gorski Maksymilian , Wodo Wojciech
Published: April 2024

Biometric authentication methods offer high-quality mechanisms to confirm the identity of individuals in security systems commonly used in the modern world, such as physical access control, online banking, or mobile device unlocking. They also find their application in cryptographic solutions, which allow the biometrically authenticated exchange of cryptographic keys between users and services on the internet, despite the fuzziness of biometric data. Such solutions are BAKE (biometrics-authenticated key exchange) and BRAKE (biometric-resilient authenticated key exchange) protocols, upon which our work is based. However, the direct application of fuzzy biometrics in cryptography, which relies heavily on the accuracy of single-bit secret values, is not trivial. Therefore, this paper is devoted to analyzing the security of this idea and the feasibility of implementing biometric AKE (authenticated key exchange) protocols, with an emphasis on the BRAKE protocol. As the results of our analysis, we discuss BRAKE’s limitations and vulnerabilities, which need to be appropriately addressed to implement the protocol in modern systems.
Enhancing Vapochromic Properties of Platinum(II) Terpyridine Chloride Hexaflouro Phosphate in Terms of Sensitivity through Nanocrystalization for Fluorometric Detection of Acetonitrile Vapors
Authors: Barzegar Sedigheh , Karimi Abdolmaleki Mahmood , Connick William B. , Absalan Ghodratollah
Published: April 2024

The vapochromic properties of [Pt(tpy)Cl](PF6) crystals in the presence of acetonitrile and its effect on the crystal structure as well as the fluorescence spectrum of this complex have already been studied in the past. We synthesized nanocrystals of this compound for the first time, and discussed different parameters and methods that affect nanocrystal structure modulation. The study demonstrates the vapochromic properties of the nanocrystals toward acetonitrile vapor by investigating the morphology and fluorescence spectra of the nanocrystals. Vapochromic studies were conducted on [Pt(tpy)Cl](PF6) nanocrystals for five cycles of absorption and desorption of acetonitrile, demonstrating shorter response times compared to regular bulk crystals.
Tailoring the Optoelectronic Properties of Soybean-Derived Nitrogen Self-Doped Carbon Dots through Composite Formation with KCl and Zeolite, Synthesized Using Autogenic Atmosphere Pyrolysis
Authors: Lagunay Rachel Anne E. , Akhetova Banu , O’Reilly Robert J. , Balanay Mannix P.
Published: April 2024

This article investigates the environmentally friendly synthesis and characterization of carbon dots (CDs) derived from soybean biomass, in conjunction with their composites containing potassium chloride (KCl) or zeolite. By using an environmentally sustainable synthetic approach, this study sought to unlock the potential of these materials for various applications. The physicochemical properties of the CDs and composites were comprehensively analyzed using various techniques including scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and X-ray diffraction analysis. In addition, various optical properties such as UV–Vis absorption, band gap, and excitation–emission behavior were investigated. A key finding to arise from this study was that the inclusion of a doping agent such as KCl or zeolite significantly reduced the size of the resulting CDs. In this light, whereas the undoped species are associated with average sizes of 8.86 ± 0.10 nm, those doped with either zeolite or KCl were associated with average sizes of 3.09 ± 0.05 and 2.07 ± 0.05 nm, respectively. In addition, it was shown that doping with either zeolite or KCl resulted in an alteration of the elemental composition of the CDs and influenced their optical properties, especially their excitation-dependent emission. These promising results point to potential applications in environmental sensing and energy-related fields.
Ferroelectric Smectic Liquid Crystals
Authors: Yoshizawa Atsushi
Published: April 2024

Since the discovery of the first ferroelectric liquid crystal (FLC) in the chiral smectic C (SmC*) phase, ferroelectricity in liquid crystals has attracted much attention due to not only the fundamental interest but also the applications. This review focuses on the evolution of the design concept for ferroelectric smectic liquid crystals. It progresses from considering macroscopic phase symmetry to designing intermolecular interactions. For the purpose of understanding the molecular organization in smectic phases, we propose a dynamic model of constituent molecules in the smectic A (SmA) and SmC* phases based on 13C NMR studies. Then, we follow the structure–property relationship in ferroelectric SmC* liquid crystals for FLC displays. We reconsider de Vries-like materials that can provide defect-free alignment. We pay attention to the electro-optical switching in the chiral de Vries smectic A phase. Finally, we show several liquid crystals exhibiting polar smectic A phases and discuss how the polar order occurs in the highest symmetric smectic A phase.
The Impact of Zoning Designations on Bird Communities: A Case Study of National Nature Reserves in Guangdong Province
Authors: Lee Myung-Bok , Zhao Xuebing , Che Xianli , Zhao Yanyan , Zhang Qiang , Liu Zhifa , Chen Daojian , Zhang Min , Zou Fasheng
Published: April 2024

One of the main management strategies of China’s nature reserve is “zonation”, dividing reserves into three zones (core, buffer, and experimental zones) to which different levels of restrictions on anthropogenic activities are applied. While zonation has a positive effect on the conservation of target species, it is unclear whether management zones can be effective in conserving biodiversity. Using bird data collected from five national nature reserves of Guangdong province in China during 2018–2019, we investigated how management zones and reserves are associated with bird diversity and community composition. We considered species richness, the community-weighted mean (CWM) values of 10 single traits, and beta diversity based on 2 dissimilarity indices (Jaccard and Bray–Curtis). The overall effects of zone management were weak or insignificant. Species richness and the CWMs of most traits were not associated with zone (p > 0.08). Reserve itself was a strong factor influencing bird traits. Dissimilarity indices also showed variations in bird community composition between reserves in the north region and those in the south region, which were largely contributed by the turnover component of beta diversity (p ≥ 0.06 for nestedness and p ≤ 0.03 for turnover in both dissimilarity indices). The dominance of turnover indicates that these reserves could be equally important to maintain regional bird diversity, requiring a multiple-site management plan. Our study also suggests that current zoning designations of the five reserves may not be as effective in conserving bird species diversity and traits; however, caution is needed due to the limitations of our study design, such as potential observer effect and insufficient sampling effort.
Bears into the Niche-Space: Phylogeography and Phyloclimatic Model of the Family Ursidae
Authors: Luna-Aranguré Carlos , Vázquez-Domínguez Ella
Published: April 2024

Assessing niche evolution remains an open question and an actively developing area of study. The family Ursidae consists of eight extant species for which, despite being the most studied family of carnivores, little is known about the influence of climate on their evolutionary history and diversification. We evaluated their evolutionary patterns based on a combined phylogeography and niche modeling approach. We used complete mitogenomes, estimated divergence times, generated ecological niche models and applied a phyloclimatic model to determine the species evolutionary and diversification patterns associated with their respective environmental niches. We inferred the family evolutionary path along the environmental conditions of maximum temperature and minimum precipitation, from around 20 million years ago to the present. Our findings show that the phyloclimatic niches of the bear species occupy most of the environmental space available on the planet, except for the most extreme warm conditions, in accordance with the wide geographic distribution of Ursidae. Moreover, some species exhibit broader environmental niches than others, and in some cases, they explore precipitation axes more extensively than temperature axes or vice versa, suggesting that not all species are equally adaptable to these variables. We were able to elucidate potential patterns of niche conservatism and evolution, as well as niche overlapping, suggesting interspecific competitive exclusion between some of the bear species. We present valuable insights into the ecological and evolutionary processes driving the diversification and distribution of the Ursidae. Our approach also provides essential information for guiding effective conservation strategies, particularly in terms of distribution limits in the face of climate change.
Designs of Optomechanical Acceleration Sensors with the Natural Frequency from 5 Hz to 50 kHz
Authors: Rezinkina Marina , Braxmaier Claus
Published: April 2024

In many applications, such as space navigation, metrology, testing, and geodesy, it is necessary to measure accelerations with frequencies ranging from fractions of a hertz to several kilohertz. For this purpose, optomechanical sensors are used. The natural frequency of such sensors should be approximately ten times greater than the frequency of the measured acceleration. In the case of triaxial acceleration measurements, a planar design with two sensors that measure accelerations in two perpendicular in-plane directions and a third sensor that measures out-of-plane acceleration is effective. The mechanical characteristics of the existing designs of both in-plane and out-of-plane types of sensors were analyzed, and the improved designs were elaborated. Using numerical simulation, the dependencies of the natural frequency level in the range from several hertz to tens of kilohertz on the designs and geometric parameters of opto-mechanical accelerometers were modeled. This allows one to select the accelerometer design and its parameters to measure the acceleration at the assigned frequency. It is shown that the opto-mechanical accelerometers of the proposed designs have reduced dissipation losses and crosstalk.
Utility of Dual-Energy Computed Tomography in Clinical Conundra
Authors: Abu-Omar Ahmad , Murray Nicolas , Ali Ismail T. , Khosa Faisal , Barrett Sarah , Sheikh Adnan , Nicolaou Savvas , Tamburrini Stefania , Iacobellis Francesca , Sica Giacomo , Granata Vincenza , Saba Luca , Masala Salvatore , Scaglione Mariano
Published: April 2024

Advancing medical technology revolutionizes our ability to diagnose various disease processes. Conventional Single-Energy Computed Tomography (SECT) has multiple inherent limitations for providing definite diagnoses in certain clinical contexts. Dual-Energy Computed Tomography (DECT) has been in use since 2006 and has constantly evolved providing various applications to assist radiologists in reaching certain diagnoses SECT is rather unable to identify. DECT may also complement the role of SECT by supporting radiologists to confidently make diagnoses in certain clinically challenging scenarios. In this review article, we briefly describe the principles of X-ray attenuation. We detail principles for DECT and describe multiple systems associated with this technology. We describe various DECT techniques and algorithms including virtual monoenergetic imaging (VMI), virtual non-contrast (VNC) imaging, Iodine quantification techniques including Iodine overlay map (IOM), and two- and three-material decomposition algorithms that can be utilized to demonstrate a multitude of pathologies. Lastly, we provide our readers commentary on examples pertaining to the practical implementation of DECT’s diverse techniques in the Gastrointestinal, Genitourinary, Biliary, Musculoskeletal, and Neuroradiology systems.
The Clinical Impact of the Pulmonary Embolism Severity Index on the Length of Hospital Stay of Patients with Pulmonary Embolism: A Randomized Controlled Trial
Authors: Donadini Marco Paolo , Mumoli Nicola , Fenu Patrizia , Pomero Fulvio , Re Roberta , Palmiero Gerardo , Spadafora Laura , Mazzi Valeria , Grittini Alessandra , Bertù Lorenza , Aujesky Drahomir , Dentali Francesco , Ageno Walter , Squizzato Alessandro
Published: April 2024

Background: The Pulmonary Embolism Severity Index (PESI) is an extensively validated prognostic score, but impact analyses of the PESI on management strategies, outcomes and health care costs are lacking. Our aim was to assess whether the adoption of the PESI for patients admitted to an internal medicine ward has the potential to safely reduce the length of hospital stay (LOS). Methods: We carried out a multicenter randomized controlled trial, enrolling consecutive adult outpatients diagnosed with acute PE and admitted to an internal medicine ward. Within 48 h after diagnosis, the treating physicians were randomized, for every patient, to calculate and report the PESI in the clinical record form on top of the standard of care (experimental arm) or to continue routine clinical practice (standard of care). The ClinicalTrials.gov identifier is NCT03002467. Results: This study was prematurely stopped due to slow recruitment. A total of 118 patients were enrolled at six internal medicine units from 2016 to 2019. The treating physicians were randomized to the use of the PESI for 59 patients or to the standard of care for 59 patients. No difference in the median LOS was found between the experimental arm (8, IQR 6–12) and the standard-of-care arm (8, IQR 6–12) (p = 0.63). A pre-specified secondary analysis showed that the LOS was significantly shorter among the patients who were treated with DOACs (median of 8 days, IQR 5–11) compared to VKAs or heparin (median of 9 days, IQR 7–12) (p = 0.04). Conclusions: The formal calculation of the PESI in the patients already admitted to internal medicine units did not impact the length of hospital stay.
The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis
Authors: Özsoy Metin , Ataman Miraç , Şahin Serhat Kazım , Şenocak İbrahim , Varlibaş Artuner , Yuvanç Ercan , Çifci Aydın , Başaralı Mustafa Kemal , Kırtıl Gül , Yilmaz Erdal
Published: April 2024

Soluble triggering receptor expressed on myeloid cells (sTREM-1) is a new biomarker that can be used for the diagnosis and monitoring of urinary system infections. This study aimed to evaluate the diagnostic performance of serum sTREM-1 in patients with a diagnosis of acute stone pyelonephritis (ASP). This prospective study included 46 patients with a diagnosis of ASP and a control group of 23 individuals without urinary system infection. Blood samples were taken from participants upon hospital admission, and basal serum sTREM-1 levels were analyzed using the ELISA method. Serum sTREM-1 concentrations were measured after treatment of ASP patients. Basal leukocyte counts, C-reactive protein (CRP) levels, procalcitonin (PCT), and sTREM-1 (98.6 vs. 68.4 pg/mL, p < 0.001) levels were higher in the ASP group compared to the control group. After treatment, the median leukocyte counts, PCT, and sTREM-1 levels decreased and were similar to those of the control group. The median CRP level also decreased after treatment, but it remained higher than that of the control group. In predicting patients with ASP, the baseline sTREM-1 exhibited a sensitivity of 74.6% and a specificity of 78.2%, while its diagnostic performance was lower than that of leukocyte counts, CRP, and PCT. Despite the findings that levels of sTREM-1 were higher upon hospital admission in patients with ASP and significantly decreased after treatment, the utility of sTREM-1 as a biomarker for predicting patients with ASP remains constrained when compared to established inflammatory markers.
Specificities in the Structure of the Cartilage of Patients with Advanced Stages of Developmental Dysplasia of the Hip
Authors: Duvančić Tea , Vukasović Barišić Andreja , Čizmić Ana , Plečko Mihovil , Bohaček Ivan , Delimar Domagoj
Published: April 2024

Developmental dysplasia of the hip (DDH) presents varying degrees of femoral head dislocation, with severe cases leading to the formation of a new articular surface on the external side of the iliac bone—the neoacetabulum. Despite conventional understanding suggesting otherwise, a tissue resembling hyaline cartilage is found in the neoacetabulum and acetabulum of Crowe III and IV patients, indicating a potential for hyaline cartilage development without mechanical pressure. To test this theory, acetabular and femoral head cartilage obtained from patients with DDH was stained with hematoxylin–eosin and toluidine blue. The immunohistochemical analysis for collagen types II and VI and aggrecan was performed, as well as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) analysis on a 7.0 T micro-MRI machine. The results obtained from DDH patients were compared to those of the control groups. Hyaline cartilage was found in the neoacetabulum and the acetabulum of patients with DDH. The nature of the tissue was confirmed with both the histological and the MRI analyses. The results of this study proved the presence of hyaline cartilage in patients with DDH at anatomical regions genetically predisposed to be bone tissue and at regions that are not subjected to mechanical stress. This is the first time that the neoacetabular cartilage of patients with advanced stages of DDH has been characterized in detail.