bluuebunny/crossref_metadata_2025 huggingface dataset:
Fine-scale map reveals highly variable recombination rates associated with genomic features in the European blackcap
Authors: Bascón-Cardozo Karen , Bours Andrea , Manthey Georg , Pruisscher Peter , Durieux Gillian , Dutheil Julien , Odenthal-Hesse Linda , Liedvogel Miriam
Published: June 2022

Recombination is responsible for breaking up haplotypes, influencing
genetic variability, and the efficacy of selection. Bird genomes lack
the protein PRDM9, a key determinant of recombination dynamics in most
metazoans. The historical recombination maps in birds show an apparent
stasis in the positioning of recombination events. This highly conserved
recombination pattern over long timescales should constrain the
evolution of recombination in birds, but extensive variation in
recombination rate across the genome and between different species has
been reported. Here, we characterise a fine-scale historical
recombination map of an iconic migratory songbird, the European blackcap
(Sylvia atricapilla) using a LD-based approach which accounts for
population demography. We found variable recombination rates among and
within chromosomes, which associate positively with nucleotide diversity
and GC content, and a negatively with chromosome size. The recombination
rates increased significantly at regulatory regions and not necessarily
at high-dense gene regions. CpG islands associated strongly with
recombination rates; however, their specific position and local DNA
methylation patterns likely influenced this relationship. The
association with retrotransposons varied according to specific family
and location. Our results also provide evidence of a heterogeneous
conservation of recombination maps between the blackcap and its closest
sister taxon, the garden warbler at the intra-chromosomal level. These
findings highlight the considerable variability of recombination rates
at different scales and the role of specific genomic features at shaping
this variation. This study opens the possibility of further
investigating the impact of recombination in specific population-genomic
features.
Anaphylaxis to Moringua oleifera in North Africa : A case report and review of the literature
Authors: Bannour Ichrak
Published: June 2022

We describe here the third reported case of anaphylaxis after ingestion
of some leavers of Moringa oleifera, causing a widespread angioedema, a
respiratory distress and an elevation of serum tryptase. Moringa
oleifera leavers were confirmed as the causative allergen by prick
testing with fresh leavers.
Modified Extended Double Patch Repair for Interventricular Septum Dissection with Ventricular Septal Rupture
Authors: kasai mio , Nakajima Shintaro , Funaishi Koji , Numasawa Yohei , Koizumi Kiyoshi
Published: June 2022

Ventricular septal rupture with dissection of the interventricular
septum is an extremely rare complication following myocardial
infarction, and the optimal surgical strategy remains unclear because of
the limited number of surgical cases. Here we report a case of
ventricular septal rupture with dissection of the interventricular
septum, which we treated using a modification of the extended double
patch technique via false lumen incision to close the ventricular septal
rupture and exclude the dissection cavity.
Association between delayed surgery and survival in early-stage cervical cancer in mainland China: Implications during the coronavirus pandemic
Authors: He Yuan , Lv Yan , Jing Ru , Ge Jun , Zou Wei , Chen Bi , Yang Hong , Li Jia
Published: June 2022

Objective The COVID-19 pandemic has had a significant impact on
oncogynecologic patients worldwide, particularly with respect to delayed
diagnosis and treatment. During the COVID-19 pandemic, few studies have
examined the impact of delayed surgery on survival in early-stage
cervical cancer patients. The purpose of this study was to determine the
effect of delayed surgical time on survival in patients with early
cervical cancer. Design A retrospective cohort study. Setting A single
general hospital in Shaanxi, Northwest China. Population A total of
1207women with early cervical cancer were recruited between April 2013
and December 2018 in Mainland China and followed up until 29 Feb 2022.
Methods This retrospective cohort study was conducted in a comprehensive
tertiary hospital in Shaanxi, Xi’an, China. We used a Cox proportional
hazard model with delay time in weeks as a categorical variable to
analyse the effect of surgical delay time on survival. Main Outcome
Measures The 5-year overall and disease-free survival were used as the
primary outcome measures. Results A total of 800 participants were
included in the final cohort. In the multivariate Cox regression
analysis (median follow-up, 58 months), patients in the long delay time
group had DFS (5-year rates, 91.5% versus 90.9%, HR 0.99, 95% CI
0.62~1.59, P=0.98) and OS (5-year rates of 92.9% versus
90.8%, HR 0.68, 95% CI 0.42~1.10, P=0.11) similar to
those in the short delay time group. Conclusions Our findings indicate
that a 12-week delay in surgery is not associated with long-term
survival in women with early-stage cervical cancer.
The Distributional Impacts of Fiscal Policy: The Case of the Philippines
Authors: Son Hyun H.
Published: June 2022

This paper examines the impacts of fiscal policies on income distribution based on two alternative social welfare functions and takes into account the case of the Philippines and its fiscal instruments. Rentals from properties, dividends from investment, and remittances from abroad were found regressive, while family sustenance activities and remittances from domestic sources were found progressive. The paper finds the direct taxes of the Philippines to be progressive, although they have limited impact on inequality reduction given the little revenues they generate.
Establishment of the music-pedagogical career of Kosta P. Manojlovic: From Oxford studies to the first pedagogical engagements
Authors: Mandic Biljana , Perkovic Ivana
Published: June 2022

Pursuant to the insight into the personal files of Kosta P. Manojlovic
(1890-1949) and other relevant archival materials, deposited in the Archives
of Serbia and the Archives of Yugoslavia, the paper examines the issue of
the beginnings of the complex professional career of this composer, music
life organizer, music performer, writer and pedagogue. Starting from the
peculiarities related to the career in the field of music, an extremely
important and delicate phase of the transition from the stage of education
to the first professional activities has been analysed. Beginning with the
correspondence connected with the career development of Kosta P. Manojlovic
at a significant moment in Serbian music history and using an
interdisciplinary approach, the important aspects of the first development
phases of the musician?s professional career have been pointed out. In
particular, most attention has been paid to the transition from education to
work, which, in the case of the Oxford graduate, was complicated, not only
because of the composer?s life circumstances, the World War I which had
ended recently, time constraints, but also because of significant
differences in education systems between the UK and the newly established
Kingdom of SCS. From the very beginning, Manojlovic?s career has shown its
multifunctional, changeable, and dynamic sides, but also certain constants,
among which his distinct inclination towards the national tradition stands
out. Regardless of the significant differences in the relation between the
present time, characterised by rapid technological changes, merging of
digital technologies with almost all spheres of life and work, new ways of
communication and numerous global phenomena, and the period in which an
?idealist romantic? Manojlovic built his own career, some of the most
important aspects related to the career development of a professional
musician have not changed. Reliance on personal capacities, musical talent,
creativity, flexibility, realism and a good assessment of one?s own
potentials, but also on the quality of education, entrepreneurship,
networking and maintaining a quality relationship with the mentor have been
noticed as extremely significant.
Contribution to the issue of internal migrations at the end of the 19th century
Authors: Kralj Marija
Published: June 2022

Serbia had been an immigrant nation for the better part of the 19th century.
It is only in the very last decade that the trend had been reversed. The
shift to emigration had been preceded by a process of various internal
migrations. They were encouraged by the liberation of the four districts -
Vranje, Nis, Pirot and Toplic - in which the acquiring new properties was
substantially encouraged by the Agrarian Law (1880) and through agrarian
loans (1882). A significant portion of the migrants coming from one of the
liberated districts, Toplica, had come from the Krusevac District.
Emigration from the Krusevac district, just like in the case of Rudnik and
Uzice, was noticed by comtemporaries and subjected to inquiry. The Ministry
of National Economy conducted a poll in 1902, testing how many residents had
moved out from the mentioned three districts in the period between the
liberation and the poll. The questions referred to their whereabouts,
motivations and general chronology. The result of the inquest were reports
detailing emigration from the Krusevac, Rudnik and Uzice districts. Within
the archives reports for a total of 51 municipalities were preserved. The
Krusevac, Rudnik and Uzice districts were composed out of 131 municipalities
in total, so the preserved information encompasses a little under a half of
the analyzed area. In total ca. 7.5 percent of the population had moved out
of the relevant settlements. They were primarily motivated by the lack of
land that can be cultivated (or at the very least, of insufficient quality).
Agrarian overpopulation had been the principle motif for around 93.5 percent
of the emigrants. It has been shown, relying on the agricultural data from
the 1889, 1893, 1897, 1900, 1901 and 1902 census (for the entirety of
Serbia), crops did not fulfill even the most basic needs of the population.
Crop yield per resident in the Rudnik and Uzice district was the lowest of
all and the situation was seldom dissimilar in the Krusevac district. The
unsatisfactory agricultural output when it came to crops was likely impacted
by unfavorable terrain. Therefore, it is hardly any wonder the emigrants had
mostly been looking for new lands. Overpopulation was likewise confirmed by
the specific dates and choice of settlement of the most frequent cases of
migration. The liberation of the four districts and the demarcation had
enticed a total of 25,09% of the total emigrants throughout 1878 and 1879.
Subsequently, the Agrarian Relations Law additionally facilitated a total of
30,1% of emigrants in 1880.
Determining Important Carrier Attributes: A Fresh Perspective Using the Theory of Reasoned Action
Authors: VOSS M. DOUGLAS , PAGE, THOMAS J. , KELLER SCOTT B. , OZMENT JOHN
Published: June 2022

The world has changed a great deal since the most recent installment in the carrier selection criteria literature. The terrorist attacks of September 11th, the recession that followed, and a current business environment characterized by constrained transportation capacity are all likely to have changed the emphasis shippers place on attributes used to select carriers. First, the authors posit three selection criteria have grown more important in the post-September 11th world. Second, the benefits of utilizing the Theory of Reasoned Action to determine the most important selection criteria, and to identify the parties in the shipping organization who value these criteria, are explained. Third, results of an exploratory study demonstrating the usefulness of the Theory of Reasoned Action to predict carrier choice are illustrated. Implications and contributions to academic research and industry practice are then discussed.
Predictive Methods for Using Capacity Data to Estimate Market Shares and the Extent of Risk Pooling by Airline Alliance Partners under Parallel Codesharing
Authors: CHEN CHIALIN , REN YU
Published: June 2022

Forming strategic alliances has become a common practice for major airlines in today's global market. The arrangement of parallel codesharing provides alliance partners serving the same route with the unique opportunity to conduct risk pooling with shared capacity and information. In this article, we develop predictive methods to analyze the effects of capacity sharing and risk pooling on the market and operational performances of airline alliance partners under parallel codesharing. We establish the interrelationship between market share and capacity through the total demands and probabilities under four different cases of demand/supply allocations between two alliance partners. We also propose methods for identifying the values of key parameters to estimate the extent of risk pooling on selected international routes. Our analyses show that risk pooling with shared capacity is a common phenomenon on the selected routes under parallel codesharing. In addition, some of the routes have rather uneven distributions of the opportunity for risk pooling between alliance partners. Several applications of the proposed methods in both the private and public sectors, such as evaluating gain-sharing by alliance partners, revising bilateral agreements, as well as fine-tuning capacity-, revenue-, and cost-sharing arrangements, are also discussed.
The Risk Adjustment of Required Rate of Return for Supply Chain Infrastructure Investments
Authors: MOON GISUNG , LeBLANC LOUIS A.
Published: June 2022

The purpose of this article is to apply a risk-adjusted required rate of return to evaluate supply chain capital investments. As part of the design methodology, a computer simulation provides expected cash flows resulting from alternative supply chain investments. These cash flows are discounted at a risk-adjusted required rate of return. The analysis represents a process to measure the risk inherent in supply chain investments. The logistics and supply chain literature has not addressed this problem of the risk inherent in a specific supply chain project. A corporate-wide hurdle rate applied to usually conservative supply chain investments may result in less than adequate investments in supply chain infrastructure. Prior studies have determined risk-adjusted required rate of return for the entire firm, an enterprise's entire supply chain network, but not an individual project within the supply chain. This study calculates a required rate of return for a specific supply chain investment project using a discrete simulation model rather than the more common mathematical model. Individual supply chain investment projects may have less risk or possibly more risk than reflected by a corporate hurdle rate or a supply chain hurdle rate. Using a standard required rate of return could result in too little or too much investment in supply chain facilities. In this study, when the risk-adjusted rate was employed to discount expected cash flows, only two of eleven alternatives evaluated were acceptable investments. The best investment with the highest return was a 12 percent increase in ship loading rate combined with a 33 percent increase in rail unloading capacity. It provided a benefit-cost ratio of 1.25. The limited availability of publicly traded firms that invest in supply chain projects represents a constraint, limiting the accuracy of estimating the market risk factor. Nevertheless, the practical implication is that, when making supply chain infrastructure investment decisions, it is advisable to adjust risk factors in evaluating such capital investments. This approach is preferable to using a corporate-wide hurdle rate, typically too high for such conservative investments. A firm-wide hurdle rate might result in under investment in supply chain facilities.
Real-Time Trailer Scheduling for Crossdock Operations
Authors: WANG JIANA-FU , REGAN AMELIA
Published: June 2022

Crossdocks play an important role in supply chain operations. Due to the need to decrease transportation lead time to coordinate with other supply chain activities such as just-in-time, make-to-order, or merge-in-transit strategies, shortening the total transfer time at crossdocks is increasingly important. In this research, we use real-time information about freight transferring within a crossdock to schedule waiting inbound trailers in order to reduce the time freight spends in a crossdock. We use dynamic simulation models to compare the performance of several strategies. These are first-come, first-served, look-ahead, minimum processing time, and minimum total time policies. We examine these under different trailer arrival headways, crossdock layouts, and destination distributions. Our simulation results show that our time-based algorithms save more time than the first-come, first-served and look-ahead policies. In addition, these algorithms appear to result in higher service reliability and productivity.
1480-PUB: Relationship between Sodium Intake with Atherogenesis in Type 1 Diabetes
Authors: KUMAR SUBHASH
Published: June 2022

Objectives: Accelerated atherogenesis can be defined as a complex procedure where the addition of facilitatory and pathogenic factors activates molecular pathways leading to the development and progression of atherosclerotic plaque. Patients diagnosed with Type-1 Diabetes bring control over the amount of sodium they consume. Despite the fact that salt intake is corresponding with blood pressure, it also partly determines the activation state of the RAAS. This study aims to determine the relationship between sodium intake and adverse outcomes among patients with diabetes. Methods: A total of 912 participants who regard their dietary intake at baseline is analyzed and assessed by the Food Frequency Questionnaire based on food groups. Results: This study found that in adults with Type-1 diabetes, low sodium intake was connected with increased risks of new-onset cardiovascular events and all-cause mortality. High sodium intake was often blamed for drastic outcomes, which leads to a “J-shaped relationship” overall. Even though BP-lowering is considerably a crucial objective for the management of diabetes, off-target actions that would help in activating the RAAS might contribute to lack of protection from CVD complications among patients with Type-1 diabetes with low levels of sodium intake.

Conclusion: This study suggested that the relationship between cardiovascular outcomes in diabetes and the amount of sodium intake is more complicated than simply being a cause of high BP.

Disclosure

S.Kumar: None.
1499-PUB: Increasing Utilization of SGLT2 Inhibitors for Cardiac Patients
Authors: RIVERA ANDREA V. , WANG XUEJUN A. , GRODSKY MICHAEL , GANDHI SHIFA , KARAISZ FRED , LEV YAIR
Published: June 2022

It is increasingly evident that SGLT2 inhibitors (SGLT2i) provide benefits for both patients with diabetes and with heart disease, however these medications are under-prescribed. Over the last few years, an interdepartmental coalition at our hospital has led to several quality improvement projects aimed at increasing SGLT2i use. Our first project focused on increasing prescription of SGLT2i by outpatient cardiologists. Our cardiology department hired a nurse practitioner to review the cardiology patient panels and identify people who might benefit from SGLT2i therapy. She assessed the percent utilization of these drugs - by the end of 24 weeks, she had reviewed 1561 charts and had increased the percentage of patients on an SGLT2i from 9.4% to 10.9%. More importantly, she created a protocol for sending informational messages to providers whose patients were eligible for SGLT2i therapy. Our team also led a project to increase inpatient SGLT2i prescriptions, evaluate barriers to their use, and assess physician comfort with inpatient initiation of therapy. To assess physician comfort with prescribing SGLT2i, we surveyed cardiologists, endocrinologists, and hospitalists regarding prescribing habits and factors preventing SGLT2i inpatient prescription. The most common factors for preventing initiation of SGLT2i therapy included unfamiliarity with evidence for SGLT2i, preference of outpatient initiation, lack of inpatient availability, and cost. To assess whether formulary availability was a barrier to inpatient use, we queried our hospital’s EMR to find the number of inpatient SGLT2i prescriptions before and after dapagliflozin and canagliflozin were added to the hospital formulary. We discovered that adding SGLT2i to our hospital formulary resulted only in a modest increase in the number of SGLT2i prescriptions. Further work needs to be done to increase the utilization of these medications.

Disclosure

A.V.Rivera: None. X.A.Wang: None. M.Grodsky: None. S.Gandhi: None. F.Karaisz: None. Y.Lev: None.
1500-PUB: Characteristics of Inpatients with DKA and SGLT2i Use at a Tertiary Hospital
Authors: WILLIAMSON SHELLEY , TAHA MOHAMAD B. , BROWN TIMOTHY R. , HEBERT SEAN , PATEL KERSHAW , NARCISSE, III VICTOR J. , SADHU ARCHANA R.
Published: June 2022

Background: SGLT-2 inhibitors (SGLT2i) have cardiovascular and renal benefits but pose an increased risk of DKA. The risk factors for developing DKA while on SLGT2i therapy have not been fully characterized.

Methods: A retrospective, observational chart review was performed to include patients admitted to Houston Methodist in 20with DKA and SGLT2i use. DKA was confirmed using standard laboratories. Potential causes of DKA were categorized based on prior published associations.

Results: Among the 61 patients with DKA, SGLT2i therapy was used at home but discontinued on admission in 46 (75%) , initiated during the hospitalization in 6 (10%) , and continued throughout the hospitalization in 9 (15%) . Potential causes of DKA were infections in 23 (38%) patients, gastrointestinal etiologies in 21 (34%) , NPO and/or perioperative status in 4 (7%) , acute cardiovascular events in 3 (5%) , and (16%) patients had no identifiable etiology.

Conclusions: Among hospitalized patients with DKA and SGLT2i use, we observed poorly controlled diabetes mellitus, with infection and GI disease being the most common associations. This description could help inform strategies to guide safe use of SGLT2i therapy.

Disclosure

S.Williamson: None. M.B.Taha: None. T.R.Brown: None. S.Hebert: None. K.Patel: None. V.J.Narcisse, iii: None. A.R.Sadhu: Advisory Panel; Abbott Diagnostics.
1502-PUB: Intensive vs. Conventional Insulin Therapy Treatment for Paediatric Diabetes
Authors: DAS A K
Published: June 2022

Background: Intensive insulin therapy is progressively replacing conventional therapy in young children to improve diabetes control. However, the specific skills required to manage insulin pumps may hamper social integration as the fear of severe hypoglycemia using conventional therapy.

Methods: Influences of a continuous education program targeting parents and their substitutes in their living places, was evaluated in 23 subjects aged 2.3 ± 0.2 years treated by insulin pump (CSII) for 3.2 ± 0.6 years and compared to 23 subjects aged 3.2 ± 0.2 years treated by conventional therapy (CV) for 3.5 ± 0.3 y.

Results: HbA1c levels were undistinguishable in both groups throughout the study period, remaining within recommended ADA target. Whereas a greater escalation of insulin dose was witnessed amongst the CV group (0.57 ± 0.to 0.79 ± 0.03 U/kg/day) versus 0.64 ± 0.to

0.70 ± 0.U/kg/day (ns) in the CSII group over time, inter-group differences failed to reach significance. BMI SDS increased significantly in the CSII group. No significant difference had been seen in the number of days of admission/ subject and the number of admissions for severe hypoglycemia. The number of admissions for ketoacidosis was high in the CSII group (p = 0.027) .

Conclusions: Externalizing targeted education programs on the child's living place allows minimizing hypoglycaemia risks of CV. This result may be particularly relevant for under-developed countries and contribute to the reduction of the costs of diabetes management without increasing side effects.

Disclosure

A.Das: None.
1504-PUB: Whole-Body Bioelectrical Impedance Analysis Reflects Levels of Hemoglobin and Hematocrit in Patients with Diabetes Mellitus
Authors: HORI TAIKI , YAMAGAMI HIROKI , YASUI SAYA , HOSOKI MINAE , HARA TOMOYO , KURAHASHI KIYOE , YOSHIDA SUMIKO , NAKAMURA SHINGEN , OTODA TOSHIKI , YUASA TOMOYUKI , ENDO ITSURO , ABE MASAHIRO , AIHARA KEN-ICHI
Published: June 2022

Aims/Introduction: Anemia is one of the common complications of diabetes mellitus (DM) and is associated with an increased risk of death. In recent years, phase angle (PhA) and the ratio of extracellular water to total body water (ECW/TBW) measured by bioelectrical impedance analysis (BIA) have been commonly used for estimating body composition. Since PhA and ECW/TBW have been reported to be useful as prognostic indicators for various chronic disease, we aimed to clarify the clinical significance of PhA and ECW/TBW in anemia of patients with DM.

Materials and Methods: The values of PhA and ECW/TBW were measured by a portable BIA device (Inbody S10, Inbody Japan, Tokyo, Japan) and blood samples were collected in 403 Japanese patients with DM (217 males and 186 females) atAnan Medical Center, Tokushima Japan. The relationships of PhA and ECW/TBW with hematocrit (Ht) and hemoglobin (Hb) were statistically evaluated.

Results: The level of PhA was decreased with age, whereas the value of ECW/TBW was increased with age. There was close inverse relationship between PhA and ECW/TBW (R2=0.7540, p< 0.001) . PhA was positively correlated with Hb and Ht levels (p <0.001, p <0.001, respectively) . In contrast, ECW/TBW was negatively correlated with Hb and Ht levels (p <0.001, p <0.001, respectively) . Multivariate regression analysis including confounding factors showed that both PhA and ECW/TBW independently contributed to Hb and Ht levels (p <0.0 and p <0.001, respectively) .

Conclusions: PhA and ECW/TBW were associated with levels of Hb and Ht in patients with diabetes. The results suggest that BIA parameters reflect red blood cell lifespan and erythropoiesis.

Disclosure

T. Hori: None. H. Yamagami: None. S. Yasui: None. M. Hosoki: None. T. Hara: None. K. Kurahashi: None. S. Yoshida: None. M. Abe: None.
1507-PUB: Degree of Glycemic Control Does Not Correlate with Nausea and Vomiting in Diabetic Gastroparesis Patients in a Phase 2 Clinical Trial
Authors: CARLIN JESSE L. , FISHER MICHAELA , MADONICK DARBY S. , KUPERSMITH CALEIGH , MOSZCZYNSKI PAULA , XIAO CHANGFU , BIRZNIEKS GUNTHER , POLYMEROPOULOS MIHAEL H.
Published: June 2022

Background: Gastroparesis is a serious medical condition characterized by delayed gastric emptying and symptoms of nausea, vomiting, bloating, fullness after meals, and abdominal pain (Camilleri et al., 2018) . One-third of gastroparesis cases are related to uncontrolled diabetes (Young et al., 2020) . HBA1C levels in diabetic gastroparesis are not associated with more or less severe vomiting episodes (Parkman et al., 2016) . Individual signs and symptoms may occur more often or with greater severity in one population compared with the other due to the degree of diabetic control. Here we did a post-hoc analysis in a phase 2 study to see if there is a correlation between baseline HBA1C and baseline gastroparesis symptoms.

Methods: Diabetic and idiopathic gastroparesis patients were screened to enroll in a phase 2 clinical trial. Patients with moderate to severe nausea and delayed gastric emptying would go onto be randomized to tradipitant 85mg BID or placebo for 4 weeks. Baseline clinical symptoms were measured by the Gastroparesis Core Symptom Daily Diary (GCSDD) . A post-hoc analysis was performed to correlate HBA1C with baseline gastroparesis symptoms in patients with diabetic gastroparesis.

Results: Patients with diabetic gastroparesis and sufficient baseline data (n=106) had baseline nausea severity of 2.5 (1.175) and baseline HBA1C of 7.366 (1.373) . There was no correlation of baseline nausea and HBA1C levels for diabetic gastroparesis (0.021) . There was no correlation of average daily vomiting, fullness, early satiety, or abdominal pain and HBA1C levels in the diabetic gastroparesis population.

Conclusion: Patients with diabetic gastroparesis experience the core signs and symptoms of gastroparesis. HBA1C levels in this population do not appear to be correlated with severity of nausea and vomiting and other core symptoms of gastroparesis.

Disclosure

J.L.Carlin: Employee; Vanda Pharmaceuticals, Inc. M.Fisher: Employee; Vanda Pharmaceuticals, Inc. . D.S.Madonick: Employee; Vanda Pharmaceuticals Inc. C.Kupersmith: Employee; Vanda Pharmaceuticals. P.Moszczynski: Employee; Vanda Pharmaceuticals, Inc. C.Xiao: None. G.Birznieks: Employee; Vanda Pharmaceuticals. M.H.Polymeropoulos: Other Relationship; Vanda Pharmaceuticals, Inc. .
1512-PUB: Glucose Removal Rate in Patients with APECED
Authors: SANDINI ERIK R. , LAAKSO SAILA , MAKITIE OUTI , PALDANIUS PAIVI M.
Published: June 2022

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED or APS-1) is a rare autosomal recessive disorder and diabetes (DM) is one of its more rare manifestations. Earlier, we have showed that reduction in fractional glucose removal rate (KG) , a known precursor of increased peripheral insulin resistance over time, was the only predictor candidate of abrupt, atypical APECED DM onset. We now explored if these changes in KG were age-dependent, and independent of DM status in all patients with APECED.

Materials and Methods: Bi-annually conducted intravenous glucose tolerance tests (ivGTT) and calculated KG values (0.693/T1/2Gluc*100) were reviewed for the Finnish APECED cohort (children and adults screened for DM in 1972-2000) . Pearson correlation coefficients (r) for KG and age at ivGTT were calculated with 2-sided p-values. A Fisher t to z transformation and a z-test were performed to investigate the difference between the groups (with DM diagnosis: DM+; without: DM-) .

Results: A total of 258 ivGTTs were performed on 13 DM+ (mean age at DM onset 27.8 ±11.7 years) and 46 DM- patients. KG values decreased over time in both groups (Figure) , with no statistical difference in the r-values between the groups (z=0.763, p=0.22) .

Conclusion: As markers of peripheral glucose uptake decline similarly over time in all patients with APECED, independent of DM status, we still lack accurate predictors of atypical DM onset in APECED.

Disclosure

E.R.Sandini: None. S.Laakso: None. O.Makitie: Advisory Panel; Kyowa Kirin Co., Ltd., Consultant; BridgeBio Pharma, Inc., Speaker's Bureau; Merck & Co., Inc. P.M.Paldanius: Consultant; Glyconics Ltd, UPM Biomedicals, Speaker's Bureau; Novartis AG, UPM Biomedicals.

Funding

Helsinki University Hospital; Foundation for Pediatric Research
1518-PUB: Role of PPARd in Regulating Autophagy Pathway in Improving Islet ß-Cell Function with GLP-1 Receptor Agonist
Authors: SU YANNA , LIN BEISI , CHEN YALAN , LIU ZIYU , GAN LU , XU WEN
Published: June 2022

Aim: To investigate the effect and mechanism of glucagon-like peptide-1 receptor agonist (GLP-1 RA) on the function of islet β cells.

Methods: Type 2 diabetes C57BL/6J mice were successfully induced by high fat diet (HFD) feeding for 12 weeks then were randomly divided into HFD+NaCl group (n=5) , HFD+Exenatide group (n=5, 24 nmol•kg-1­•d‑1) and NC group (n=5) . Tolerance tests and insulin measurement were performed after 8 weeks of drug therapy. Weight was measured weekly and fasting blood glucose was measured every 4 weeks. The pancreas were stained with LC3B Immunofluorescence at the end of the experiment. The PA induced primary islet β cells were treated with exendin-4 and PA induced Min6 cells were treated with exendin-4, GW501516 for 24h, which BSA as the control group, then detected the protein levels of PPARδ, LC3B-II and P62. At the same time, PA induced MIN6 cells were treated with GSIS. What's more, we silenced PPARδ transfected with siRNA to verify the role of PPARδ in GLP-1 receptor agonist activation of β-cell autophagy.

Results: Compared with the normal control group, the body weight and fasting blood glucose increase and significant peripheral insulin resistance in the high fat group, while the above indexes are significantly improved in the high-fat fed mice after GLP-1 RA treatment. Immunofluorescence biopsies of pancreatic tissue show that LC3B expression decrease after high fat diet, while GLP-1 RA intervention significantly increase. In addition, GLP-1 RA not only can promote the expression of PPARδ and LC3B-II protein and inhibit the expression of P62 protein in primary islet β cells and MIN6 cells, but also significantly increase glucose stimulation insulin secretion in MIN6 cells. More importantly, GW501516 is found to be consistent with GLP-1 RA in MIN6 cells, while GLP-1 RA promote autophagy disappeare after PPARδ expression is silenced.

Conclusion: GLP-1 RA can improve the function of islet β cells by activating the autophagy pathway through PPARδ.

Disclosure

Y.Su: None. B.Lin: None. Y.Chen: None. Z.Liu: None. L.Gan: None. W.Xu: None.

Funding

Science & Technology Project of Guangzhou（202102010175）
Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial
Authors: Heianza Yoriko , Krohn Knut , Meir Anat Yaskolka , Wang Xuan , Ziesche Stefanie , Ceglarek Uta , Blüher Matthias , Keller Maria , Kovacs Peter , Shai Iris , Qi Lu
Published: June 2022

  

Objective: To investigate whether changes in circulating levels of pancreatic islet-related microRNA-375 (miR-375) were related to improved visceral and intrahepatic fat accumulation. 

Research Design and Methods: This study included adults with abdominal obesity from an 18-month weight-loss lifestyle intervention trial. Circulating miR-375-3p was measured at baseline and 18 months. The magnetic-resonance-imaging (MRI) was performed (n=139) to assess 18-month changes in abdominal and intrahepatic fat depots.

Results: Circulating miR-375-3p was related to fasting insulin and insulin resistance in participants with pre-diabetes. After the interventions, there was a significant increase of miR-375-3p (p <0.001). Greater increase in miR-375-3p was associated with larger reductions of visceral (p=0.024) and deep subcutaneous adipose tissues (p <0.001), and intrahepatic fat content (p=0.012).

Conclusions: Increases in circulating miR-375-3p were associated with visceral and intrahepatic fat reduction. Changes in circulating pancreatic islet-related miR-375-3p may be linked to improved diabetogenic fat depots during weight-loss lifestyle interventions. 
Uso del corcho como aislante térmico en viviendas prefabricadas – Caso de Estudio: Ticlio Chico
Authors: Lopez Villanueva Alexandra Yunek , Yucra Ayala Maddeley Elizabeth , Cisneros Echavarría Noemi Gloria , Acuña del Carpio Gabriella
Published: June 2022

El cambio climático mundial y especialmente los escenarios de frío extremo observados en los últimos años han afectado seriamente las zonas más vulnerables de nuestro país. Las viviendas construidas con materiales inadecuados y la incapacidad de utilizar mecanismos de calefacción, generan un impacto directo sobre la salud de sus pobladores. Por lo tanto, se requiere que estas viviendas sean eficientes energéticamente con sistemas económicos. El principal objetivo de esta investigación es evaluar la eficiencia del uso de planchas de corcho como revestimiento en el interior de viviendas prefabricadas. El caso de estudio es el AA. HH Ticlio Chico, donde se alcanzan bajas temperaturas, humedadrelativa cercana al 100% y sensación térmica aproximada de 8.5°C. Se realizó el ensayo experimental de tres prototipos de vivienda a escala reducida con diferentes espesores de planchas de corcho sometidos a variaciones de temperaturas. Luego, se realizó un análisis dinámico térmico del modelo numérico del prototipo. Finalmente, se analizaron los resultados de registros de temperaturas obtenidos experimental y numéricamente, determinando así la eficiencia del uso de planchas de corcho. Esta investigación contribuye para alcanzar el confort térmico en viviendas prefabricadas en las zonas más desprotegidas del país.
Análisis comparativo del tratamiento de efluentes cianurados con peróxido de hidrógeno y metabisulfito de sodio
Authors: García Girón Arturo , Loroña Calderon Frank
Published: June 2022

El trabajo de investigación tuvo por objetivo determinar la mejor opción de tratamiento para la destrucción del cianuro de sodio en solución Barren o solución pobre, proveniente de la Planta de Procesos unidad minera El Toro de manera que cumplan con los valores esperados por debajo de los Límites Máximos Permisibles (Decreto Supremo N°010-2010-MINAM) relacionados con el cianuro total. La investigación se realizó mediante dos propuestas de tratamientos: La destrucción de cianuro con peróxido de hidrógeno y la destrucción del cianuro con metabisulfito de sodio. Se concluye que la reducción de cianuro más efectiva fue con metabisulfito de sodio alcanzando una concentración final de cianuro de 23.23 mg/L mientras que el peróxido de hidrógeno alcanzó una concentración final de 12.94 mg/L en un tiempo de 15 minutos, respectivamente. Si bien el costo de tratamiento por metro cúbico de solución Barren del peróxido de hidrógeno(S/. 2.63) fue menor que el metabisulfito de sodio (S/. 7.26), su consumo fue mayor a fin de alcanzar una mejor reducción de cianuro para la calidad de la muestra barren analizada.
Community of Inquiry Framework: Research Trends Between 2000-2020
Authors: Olpak Yusuf Ziya
Published: June 2022

The current study aimed to understand the trend in the community of inquiry that many researchers have been working on for over 20 years. Within the scope of this aim, 102 studies were reviewed with regards to some variables: most preferred keywords and words in abstract, year of publication, authors, journals, geographical distribution, academic disciplines, research methods, course delivery methods, participant type, and references. The findings demonstrate that the articles reviewed were from 216 authors in 20 countries. Most of the studies were from the Social Sciences field, and the continent with the most studies was North America. Quantitative research methods were mostly preferred in the studies, and the study group of a great of majority the studies were higher education students. Finally, various recommendations were made for future research after determining gaps that exist in the current literature.
An Overnight Educational Transformation: How did the Pandemic Turn Early Childhood Education Upside Down?
Authors: Aslan Sinem , Li Qi , Bonk Curtis J. , Nachman Lama
Published: June 2022

Since the spring of 2020, many early childhood education programs (pre-K, K, 1st, and 2nd grades) had to close as governments around the world took serious measures to slow down the transmission of COVID-19. As a result, the pandemic forced many early childhood teachers to start teaching online and continue supporting their students remotely. Unfortunately, there were few lessons that these teachers could learn from experience to cope with this change since online learning in early childhood settings had been scarce until the outbreak of the pandemic. In response, the goal of this interview study was to investigate how early childhood teachers in public and private schools implemented online learning during the pandemic, the challenges they encountered when teaching online, and their suggestions to address these challenges. The results showed that the teachers did not sit still and patiently wait for the re-opening of the schools. Instead, they took assorted initiatives to support their students’ learning and development remotely. They faced several challenges on the way but also suggested various methods to address these challenges through developmentally appropriate technology use. The results of this study have implications for teachers when early childhood programs return to normal. The study creates opportunities for future research to gain greater understanding of the design and implementation of online learning activities with young learners.
Investigation of Science Teachers’ Professional and Scientific Attitudes
Authors: KARAALİOĞLU ÇAKIR Serpil , KADIOĞLU AKBULUT Cansel
Published: June 2022

Purpose: The aim of this study is to investigate the level of science teachers’ professional and scientific attitudes, whether these variables differ according to gender and the relationship between two variables.

Design/Methodology/Approach: It is conducted through survey design based on quantitative research. A total of 174 science teachers (91 females and 83 males) working in public middle schools participated. The data were collected using “Attitudes towards Teaching Profession Scale” and “Scientific Attitudes Scale”. Additionally, qualitative data were collected through “Demographic Information Form” to support quantitative findings. Descriptive statistics, independent samples t-test and Pearson correlation analysis techniques were used in quantitative data analysis. Besides, descriptive analysis technique was used to analyze qualitative data.

Findings: Results revealed that science teachers possessed highly positive attitudes towards teaching profession, and their scientific attitudes were at moderate level. While female teachers’ professional attitudes were found to be more positive, scientific attitudes did not change by gender. There was a moderate and positive relationship between two variables. Science teachers choose their profession mainly for affective reasons such as loving teaching. Moreover, although teachers mostly attended in-service training programs, they were not trained on nature, history or philosophy of science to improve scientific attitudes. Finally, it was discovered that TUBITAK publications were popular among science teachers.

Highlights: Although science teachers possess positive attitudes towards their profession, their scientific attitudes found to be moderate. In the Information Age, scientific attitudes of teachers are of great importance as well as their attitudes towards their profession. In order to support teachers’ scientific attitudes, in-service trainings on the nature, history, or philosophy of science can be developed, implemented, and evaluated.
PENGARUH KREATIVITAS, MODAL USAHA, DIVERSIFIKASI PRODUK DAN KEBIJAKAN PEMERINTAH TERHADAP KEBERLANJUTAN BISNIS UMKM (STUDI PADA UMKM BIDANG PERDAGANGAN DI KELURAHAN IRINGMULYO KOTA METRO)
Authors: Azzahra Cika Irlia , Suyanto Suyanto , Darmayanti Elmira Febri
Published: June 2022

This study aimed to examine the influence of creativity, business capital, product diversification and government policies on business sustainability in the Trade Sector UMKM in Iringmulyo Village, Metro City. The sampling method used was convenience sampling, until a total sample of 86 business actors was obtained. This study used a quantitative approach. The data used are primary data from the results of distributing questionnaires. The data were then processed with IBM Statistics SPSS 24. The results of this study indicated that partially creativity had an effect on business sustainability, business capital had no effect on business sustainability, product diversification had an effect on business sustainability, government policies affected business sustainability as well as simultaneously creativity, capital. business, product diversification and government policies affected business sustainability.Key words: creativity; business Capital; product diversification; government policy; UMKM business continuity
PENGARUH TEKNOLOGI INFORMASI BERBASIS E-COMMERCE TERHADAP MINAT MAHASISWA DALAM BERBELANJA ONLINE
Authors: Pramono Indra Dwi , Suyanto Suyanto , Darmayanti Elmira Febri
Published: June 2022

Penelitian ini bertujuan Untuk mengetahui Pengaruh Teknologi Informasi Berbasis E- Commerce Terhadap Minat Mahasiswa Dalam Berbelanja Online Pada Mahasiswa Program Studi Akuntansi Fakultas Ekonomi Dan Bisnis Universitas Muhammdiyah Metro. Jenis penelitian ini adalah penelitian kuantitatif dengan data yang digunakan adalah data lapangan (field research). Pengumpulan data diperoleh dari hasil kuisioner kepada 100 mahasiswa program Studi Akuntansi yang diambil menggunakan rumus dari slovin. Analisa data penelitian dilakukan dengan menggunakan analisis data kuantitatif dengan pengujian persyaratan instrumen, Persyaratan analisis dan hipotesis. Hasil penelitian menunjukkan bahwa Variabel Persepsi Kemudahan Pengguna berpengaruh positif dan signifikan terhadap Minat Berbelanja Online. Sedangkan variabel Persepsi Kegunaan berpengaruh signifikan terhadap Minat Berbelanja Online.
Analisis Penerapan Sistem Akuntansi Keuangaan Sesuai PP No 71 tahun 2010 Pada Badan Pengelola Keuangan Daerah Kota Pematangsiantar
Authors: Manjana Ajeng , Nasution Juliana
Published: June 2022

Badan Pengelola Keuangan Daerah (BPKD) merupakan badan atau unit pelaksana dalam membantu pemerintah dalam pengelola keuangan. BPKD mempunyai tanggung jawab dalam menyusun laporan keuangan pelaksanaan APBD. BPKD di bentuk agar dalam mengelola keuangan daerah tertata dengan baik sehingga prosedur operasi standar pengelolaan pendapatan dapat membantu menungkatkan akuntabilitas dan kinerja keuangan daerah. Di Indonesia SAP yang berlaku hingga sekarang yaitu standar akuntansi pemerintah basis akrual yang kemudian diatur dalam “PP Republik Indonesia No. 71 tahun 2010 mengenai standar akuntansi pemerintah”. Tujuan dari penelitian ini yaitu untuk mengetahui dan mengkaji penggunaan sistem akuntansi keuangan pada Badan Pengelola Keuangan Daerah (BPKD) Kota Pematangsiantar. Metode penelitian yang penulis gunakan didalam penelitian ini yaitu metode kualitatif deskriptif. Berdasarkan hasil daripada penelitian bahwa Badan Pengelola Keuangan Daerah Kota Pematangsiantar secara umum telah menerapkan sistem akuntnasi seseuai dengan “PP No. 71 tahun 2010 mengenai standar Akuntansi Pemerintah Berbasis Akrual pada Pemerintah Daerah”.
IMPLEMENTASI PELAPORAN KEUANGAN MENURUT PSAK 109 PADA LEMBAGA AMIL ZAKAT, INFAQ, DAN SHADAQAH MUHAMMADIYAH
Authors: Suryani Suryani , Suyanto Suyanto , Septiani Ana
Published: June 2022

Islam mempunyai lembaga pemberdayaan umat salah satunya yaitu zakat. Dengan adanya zakat masyarakat dapat menyalurkan sebagian hartanya untuk diberikan kepada yang berhak menerimanya. Namun di Indonesia untuk saat ini belum sepenuhnya mampu mengoptimalkan potensi zakat bagi kesejahteraan umat karna kuranganya kepercayaan antara muzzaki terhadap organisasi pengelolaan zakat. Maka dari itu lembaga zakat, infaq, dan shadaqah perlu mempunyai laporan keuangan yang sesuai dengan SAK yang berlaku. Penelitian ini bertujuan untuk mengetahui pelaporan keuangan dan implementasi PSAK 109 pada Lazismu Kota Metro. Penelitian ini menggunakan pendekatan kualitatif dengan pendekatan analisis deskriptif. Sumber data yang digunakan diperoleh dari data sekunder dan data primer sedangakan untuk tehnik pengumpulan data menggunakan wawancara, dokumentasi, dan observasi. Hasil penelitian ini bahwa Lazismu Kota Metro dalam pelaporan keuangan dan implementasi PSAK 109 sudah sesuai dengan PSAK 109 yang berlaku