bluuebunny/crossref_metadata_2025 huggingface dataset:
Components of the Tactical Athlete Model
Authors: Martinescu-Bădălan Fabiana , Macovei Crenguţa-Mihaela
Published: July 2023

Sport is a basic pillar in the training of any military, be it NCO or officer. Primarily, tactical fitness refers to the type of fitness required to assist active duty military, police, firefighters, and other professions who must be the first at the scene in the case of an emergency. It also applies to those who want to serve in the military or other similar professions. Last but not least, it also applies to everyone who wants to be in better physical condition to survive a potentially dangerous situation, such as a natural disaster or saving someone from a burning house until the fire department and the paramedics arrives. Tactical fitness is the difference between life and death in these circumstances. Sometimes the question must be asked if we are prepared enough to save ourselves or save someone from a disaster. Many people working in these fields need to know how to properly prepare their workouts to fit the needs of demanding schedules and jobs. For those who do not work in these fields, just being able to save themselves or a family member from situations that require endurance, strength and physical discipline is reason enough to train in a certain way, at a certain standard.
The Communication Between Doctor and Vulnerable Groups from a Multicultural Perspective
Authors: Paşca Maria-Dorina
Published: July 2023

In a world where population is growing and the percentage of vulnerable groups is increasing, cultural sensitivity requires very special attention. It is not surprising that cultural factors play a very important role in the healing process, outlining the response to disease and treatment. From Hippocratic Oath to the Romanian legal texts, all argue for a conduit for patients regardless of culture, race, ethnicity, religion. The vulnerable groups are: minorities, people with disabilities, pregnant women, children, whose self-image, and whose hole life is affected, the more they are under the influence of a medical context. We are the richest when we have health, and we are entitled to it, all of us, regardless of where we come from and where we are headed. In this context, medical communication with vulnerable groups has its specificity, given both the professional ethics and the cultural traditions of those concerned.
Social Values, Attitudes and Gender Stereotypes in Romania
Authors: Rusu Raluca
Published: July 2023

In this paper we will analyze the value orientation of Romanians, starting from the indicators from the Word Values Survey (is a global network of social scientists studying changing values and their impact on social and political life) which are based on the value change model of R. Inglehart (2005). The author configures a cultural map of the world, based on two axes: traditional values versus secular-rational values and survival values versus self-expression values. Starting from these axes, the author identifies the orientations of the predominant values of the societies. In Romania, the traditional and survival values are more specific, so the orientation towards the acceptance of different ones is weaker, including what concerns gender values. As a result, stereotypes, including gender stereotypes, still work.
Neurotrophin-3 gene polymorphism in schizophrenia and its relation with diseases severity and cognitive dysfunction
Authors: Keshri Neha , Nandeesha Hanumanthappa , Rajappa Medha , Menon Vikas
Published: July 2023

Objectives:

Synaptic plasticity markers are known to alter in schizophrenia. The objective of the study was to investigate the genotype and allele frequency of neurotrophin-3 (NT-3) gene polymorphism (rs6489630, rs6332, and rs11063714) and plasma NT-3 levels in schizophrenia and their relation with cognitive status.

Materials and Methods:

The study was conducted on 216 Schizophrenia patients and 216 controls. Single-nucleotide polymorphism (SNP) of NT-3 and its plasma levels were assessed in both groups. Cognitive status was evaluated using Addenbrooke Cognitive examination-III scores.

Results:

The rs6489630 polymorphism was found to be significantly associated with the severity of schizophrenia (P = 0.004). The CT genotype (P = 0.02, OR = 1.631 [1.10–2.43]) and minor allele T (P = 0.004, OR = 1.58 [1.16–2.16]) of rs6489630 conferred an increased susceptibility to develop schizophrenia. The rs6332 variant was found to affect cognitive status significantly in schizophrenia (P = 0.040), and memory dysfunction was seen in individuals with AG (P < 0.01) and AA variant (P = 0.03) of rs6332.

Conclusion:

We conclude that SNPs of NT-3 enhance the risk of schizophrenia and are related to cognitive dysfunction.
Lumbar facet joint arthrosis on magnetic resonance imaging and its association with low back pain in a selected Ghanaian population
Authors: Dzefi-Tettey Klenam , Edzie Emmanuel Kobina Mesi , Mensah Simpson Kudjo , Osei Samson , Piersson Albert Dayor , Amedi Michael Kofi , Asemah Abdul Raman , Kusodzi Henry
Published: July 2023

Objectives:

Facet joint arthrosis is a common radiologic finding but remains controversial as a source of low back pain. We conducted a study to evaluate some of the potential risk factors contributing to the development of facet joint arthrosis, such as age, gender, and body mass index (BMI). The study aimed at establishing an association between these factors and facet joint arthrosis in the Ghanaian population, as a foundation for further research on low back pain.

Materials and Methods:

This was a retrospective study done at the Department of Radiology, Korle Bu Teaching Hospital from January 2019 to December 2021. The study population included all cases referred to our department with complaints of low back pain. Patients below 18 years and those with a history of congenital lesions, trauma, infection, and malignancies were excluded. A total of 1017 cases were identified with facet joint arthrosis. The mean difference in age and BMI between males and females was compared using an independent sample t-test. Statistical association was done using Pearson’s Chi-square test. P ≤ 0.05 was used as statistical significance.

Results:

Majority of the study subjects were overweight with a mean BMI of 27.31 ± 5.37 kg/m2. The mean age was 53.61 ± 16.22 years, and majority were within the age of 51–60 years. Age was significantly associated with the prevalence of facet joint arthrosis.

Conclusion:

The prevalence of facet joint arthrosis is significantly associated with increasing age but not with the BMI. Lumbar facet joint arthrosis is more prevalent in women than in men, which may be due to the sensitivity of cartilage to female sex hormones.
Dilbilimsel karşılaştırma metodu ile çeviride eşdeğerlik sorunları: Çağrı filmi örneği
Authors: DEMİREKİN Murat
Published: July 2023

Her çeviri, çevirmenin başka bir dildeki bilgi ve algısıyla şekillenen farklı bir yorumu temsil eder. Görsel veya işitsel bir eserin çevirisinde ise kaynak dildeki mesajın erek dile ne kadar doğru aktarılabildiği çok önemlidir. Çalışmada Çağrı adlı film model alınmak suretiyle dilbilimsel çeviri yöntemi çerçevesinde, iki dil arası eşdeğerlik sağlama sorunları ele alınmıştır. Çalışmanın amacı, diller arası eşdeğerlik kavramını çeviri kuramları çerçevesinde irdelemek, dikkat çeken çeviri ve yorum sorunlarını belirlemektir. Bu amaçla ve İslamiyet’in doğuşunu konu alan ünlü “Çağrı” filminin Türkçe dublaj çevirisine odaklanarak eşdeğerlik sağlama stratejileri bağlamında çözüm önerileri sunulmaktadır. Kaynak dil İngilizcedeki kelime, cümle ya da anlamsal içeriklerin erek dil olarak Türkiye Türkçesine çevrilirken, aslına uygun çağrışımları içerip içermediği, çeviride anlam kayıpları, düz veya yan anlamsal ögelerin örtüşüp örtüşmediği, dilbilgisel ve morfolojik birimlerin karşılıklarının olup olmadığı gibi sorunsallar değerlendirilmiştir. Çalışma, doküman veri analizi modelini kullanan nitel bir yaklaşımı benimsemektedir. "Çağrı" filminin Türkçe versiyonu dilbilimsel karşılaştırma yöntemiyle, kelime, dil bilgisi, metinsel ve pragmatik boyutlardaki çeviri ve yorumları açısından incelenmiştir. Bu kapsamda, filmin İngilizce orijinal versiyonu ile Türkçesi dublajlı versiyonu dakika dakika karşılaştırmalı izlenmiş; erek dil Türkçede sözcüksel, dilbilgisel, metinsel ve anlamsal düzeyde eşdeğerlik ilkelerine tam uymayan kesitler sırayla tespit edilmiştir. Tespit edilen eşdeğerlik sorunları tablolar halinde ilgili düzeyler halinde sıralanmıştır. Ardından, çeviribilimde sunulan yaklaşımlar bağlamında eşdeğerlik sağlanabilmesi için çözüm önerileri sunulmuştur.
Nonlinear Retarded differential Equations with Nonlocal History Conditions
Authors: Saxena Shalabh
Published: July 2023

In this paper we prove the existence and uniqueness of a strong solution of nonlinear
retarded differential equation with a nonlocal history condition using the method of
semidiscretization in time. Some applications of the abstract results is given in last
section.
Parameter Augmentation For Basic Hypergeometric Series By Cauchy Operator
Authors: Agnihotri Aditya
Published: July 2023

In paper [1], certain new summation and transformation formulae for basic hypergeometric series by using the Cauchy augmentation operator are established. In the present paper, we shall deal with parameter augmentation by using Cauchy augmentation operator in some more known identities and establish some new results.
2-Divisor Lucky Labeling of some Identity Graphs of Finite Group and some Zero-Divisor Graphs
Authors: Sakthi K. Aruna , Rajeswari R. , Meenakumari N.
Published: July 2023

A graph be a graph with n vertices and m edges. A graph G admits 2-divisor luckylabeling if be a labeling of vertices of graph G from {1,2,3,…,n}. Definewhere N(v) is the neighborhood of v such that s(u) ≠ s(v) for every pair ofadjacent vertices u and v in G. The vertex 2-divisor lucky number is the least number from theset {1,2,…,n} that has been used to label the graph G. It is denoted by In this paper wehave investigated for some types of identity graphs of finite group and some zero-divisor graphs
Analisis Kinerja Saham dan Rasio Keuangan Pada Japfa Comfeed Indonesia Tbk (JPFA)
Authors: Rizki Akbarianto Binas Samudra  , Daud Syah Habibi  , Syahwani Asty , Lesia Fatma Ginoga  , Resti Jayeng Ramadhanti
Published: July 2023

Analysis of the selection of stocks to invest can be seen by measuring stock performance based on stock returns and risks that will be borne by investors. Beside of stock performance, investors also pay attention to the company's financial performance by calculating the company's financial ratios. This study aims to determine the stock performance and financial ratios of the JAPFA Comfeed Indonesia (Tbk) company. The analytical method in this study uses secondary data in the form of stock price data and company financial reports. The results of the study show that returns for the August 2022 period produce better returns. Meanwhile, September 2022 experienced a drastic decrease from the previous year so that it experienced a loss. The average risk value for August 2022 is 1.87% and September 2022 is 1.40%. Macro analysis can be seen that the company still imports raw materials by 30%, so the company is more consistent in managing finances, controlling cash wisely, and focusing on increasing efficiency and profitability. The results of the analysis in this study indicate that JAPFA's financial ratios can be categorized as quite good.

Abstrak

Analisis pemilihan saham untuk berinvestasi dapat dilihat dengan melakukan pengukuran kinerja saham berdasarkan return saham dan risiko yang akan ditanggung oleh investor. Selain kinerja saham, investor juga memperhatikan kinerja keuangan perusahaan dengan menghitung rasio keuangan perusahaan. Tujuan penelitian ini adalah mengetahui bagaimana kinerja saham dan rasio keuangan perusahaan pada JAPFA Comfeed Indonesia (Tbk). Penelitian ini menggunakan data sekunder yang berasal dari data harga saham dan laporan keuangan perusahaan. Hasil penelitian menunjukkan return untuk periode bulan Agustus tahun 2022 menghasilkan return yang lebih baik. Sedangkan, bulan September 2022 mengalami penurunan drastis dari tahun sebelumnya sehingga mengalami loss. Nilai rata-rata risiko Agustus 2022 1,87% dan September 2022 1,40%. Analisis makro dapat dilihat perusahaan masih impor bahan baku sebesar 30%, maka perusahaan lebih konsisten dalam mengelola keuangan, mengendalikan kas dengan bijaksana, serta fokus dalam peningkatan efisiensi dan profitabilitas. Hasil analisis dalam penelitian ini menunjukkan bahwa rasio keuangan Perusahaan JAPFA dapat dikategorikan cukup baik.
Latent Trait Item Response Models for Continuous Responses
Authors: Tutz Gerhard , Jordan Pascal
Published: July 2023

A general framework of latent trait item response models for continuous responses is given. In contrast to classical test theory (CTT) models, which traditionally distinguish between true scores and error scores, the responses are clearly linked to latent traits. It is shown that CTT models can be derived as special cases, but the model class is much wider. It provides, in particular, appropriate modeling of responses that are restricted in some way, for example, if responses are positive or are restricted to an interval. Restrictions of this sort are easily incorporated in the modeling framework. Restriction to an interval is typically ignored in common models yielding inappropriate models, for example, when modeling Likert-type data. The model also extends common response time models, which can be treated as special cases. The properties of the model class are derived and the role of the total score is investigated, which leads to a modified total score. Several applications illustrate the use of the model including an example, in which covariates that may modify the response are taken into account.
Preparation Activated Carbon from Scrap Tires by Microwave Assisted KOH Activation for Removal Emulsified Oil
Authors: Majeed Najwa Saber , Sabbar Huda Adil , Al-Musawi Nawar O. A.
Published: July 2023

In this paper activated carbon adsorbents produced from waste tires by chemical activation methods and application of microwave assisted KOH activation. The influence of radiation time, radiation power, and impregnation ratio on the yield and oil removal which is one of the major environmental issues nowadays and considered persistent environmental contaminants and many of them are suspected of being carcinogenic. Based on Box-Wilson central composite design, polynomial models were developed to correlate the process variables to the two responses. From the analysis of variance the significant variables on each response were identified.  Optimum conditions of 4 min radiation time, 700 W radiation power and 0.5 g/g impregnation ratio gave 205.8749 mg/g oil removal and 35.19618 % yield. The characteristics of the AC were examined by pore structure analysis, and scanning electron microscopy (SEM).The BET surface area and total pore volume were identified to be 374.594 m²/g and 0.2039 m³/g, respectively.
ANALISIS SEBARAN HASIL HUTAN JENIS KAYU BULAT DI INDONESIA MENGGUNAKAN ANALISIS KORESPONDENSI
Authors: Rivqy Ramadhani Putra Dipha  , Khadijah Shafa , Nugroho Risky , Eka Lestari Karunia , Rahmawati Utami Marsah
Published: July 2023

Produksi hasil hutan jenis kayu bulat dipengaruhi oleh faktor geografis seperti letak geografis hutan penghasil kayu yang tersebar di pulau-pulau di Indonesia. Statistik produksi kehutanan Indonesia pada 2020 telah dirilis oleh BPS-Statistics Indonesia dan dianalisis secara deskriptif. Artikel ini menyajikan perspektif lain dari yang telah dipublikasikan oleh BPS-Statistics Indonesia. Analisis sebaran hasil hutan jenis kayu bulat di Indonesia dilakukan dengan pendekatan grafis menggunakan analisis korespondensi. Keterkaitan antara produksi hasil hutan jenis kayu bulat berdasarkan pulau di Indonesia beserta kontribusinya, diidentifikasi dan diinterpretasikan melalui plot asimetris dan biplot kontribusi. Hasil yang diperoleh menunjukkan bahwa terdapat keterkaitan yang erat antara jenis kayu akasia dengan Pulau Sumatra, kelompok meranti dengan Pulau Kalimantan, kelompok indah dengan Jawa, dan kelompok eboni dengan Pulau Maluku & Papua. Lebih lanjut, kelompok meranti merupakan kategori jenis kayu yang memiliki kontribusi paling besar di dalam analisis.

 

Kata kunci: analisis korespondensi, produksi kayu bulat, plot asimetris, biplot kontribusi
Unearthing the Cultural Values of Personalities in Photorealism Portraiture: The Iconography of the Works of the Ghanaian Fine Artist, Samuel Otu
Authors: Adom Dickson , Otu Samuel , Kombui Babaaradio , Adu-Agyem Joe , Fening Peggy Ama
Published: July 2023

The roots of portraiture are most likely to be traced to if not prehistoric times, at least ancient Egyptian civilization. Over time, various forms, styles and significance of this genre emerged progressively in line with the various artistic traditions in history. In these contemporary times, portraiture strives immensely on the advancement of technology thereby giving rise to photorealism not only in the West but also among African/Ghanaian fine artists. The Erwin Panofsky’s three-step approach to iconographic analysis was used to examine five meticulously pencil-rendered portraits by the Ghanaian photorealist Samuel Otu in the light of contemporary portraiture. The paper utilized a series of one-on-one interviews with the artist amidst studio observation to obtain primary data alongside relevant secondary sources of data. It was revealed that beyond the subjectivity or likeness of the subjects portrayed, the artist used these masterpieces to draw the attention of the viewer to the contemporary challenges of the African society.
Is creeping abandon of human cancer defences evolutionarily favoured?
Authors: Rahm Alexander D. , Pratley Pierre
Published: July 2023

Among the animal species on which observations are available, humans have a uniquely high lifetime risk to suffer from cancer - over 38\%, compared to less than 10\% for all observed other species (except species suffering from environmental pollution). Peto's paradox shows that this cannot simply be explained by mathematical models which view cancer genesis as a stochastic process, with resulting risks polynomial in lifespan and body mass - whales have a longer lifespan and about 30 times the human body mass, however their cancer risk remains constant throughout their life rather than increasing sharply after female reproductive age as observed in humans. Rather, it is well documented in the literature that species-specific tumour suppression mechanisms allow for large lifespan and body mass. Chimpanzees, being closely related to humans, have a very low cancer risk, and hence the weakness of human cancer defence is likely to have resulted from the specific development of Homo sapiens. As this weakness appears past the reproductive years, a prominent hypothesis blames it to antagonistic pleiotropy. However, Homo sapiens having lived in small tribes during most of its development, natural selection is likely to also have acted at the level of tribes, and higher degrees of inbreeding would quite certainly have been detrimental to a tribe. And males of high social status can attract new reproductive partners again and again until an age that has seen several generations grow, which in case of a not-so-large tribe would have considerably narrowed down its genetic pool. Furthermore, lowering tumour suppression activities might save calories and hence benefit tribes with limited food production; and individuals suffering from cancer after female reproductive age could still have made contributions to parental/grandparental care, while no more being attractive as a reproductive partner. So, we arrive at the mentioned hypothesis: Is creeping abandon of human cancer defences evolutionarily favoured?
The Impact of physical exercise and alcohol conditions on self-reported health among cancer patients? An analysis of the Health Information National Trends Survey 2019
Authors: Guan Ming
Published: July 2023

BACKGROUND AND OBJECTIVE: Sleep hours, physical exercise, and alcohol conditions were report to reduce or increase the detrimental side effects of cancer treatment. This study was aimed to evaluate the associations of outcomes of physical exercise and alcohol conditions with poor health among cancer patients when controlling socioeconomic factors. The secondary aim was to evaluate the joint effects of multiple cancers in the association of sleep hours, physical exercise, and alcohol conditions with poor health among cancer patients.

METHODS: The data were from the Health Information National Trends Survey (HINTS) Wave 5 Cycle 3 administered by the National Cancer Institute since 2003 in the United States of America. Chi-square test and orthogonality tables were employed to assess the difference between pairs of variables. Logit regressions with marginal odds ratios (MOR) and 95% confidence intervals (95% CI) were conducted to examined the associations of socioeconomic variables with disadvantages of alcohol conditions and benefits of physical activity, respectively. King et al.'s (2000) simulation-based approach was employed to explore the moderating effects of multiple cancers on the associations of interest. Simulation extrapolation was conducted to examine the roles of socioeconomic factors, benefits of physical activity, and disadvantages of alcohol conditions in the fair/poor self-reported health (SRH) among cancer patients.

RESULTS: The mean age of the sample was 69.79 ± 7.10, (range = 60 to 99) years old. Compared to cancer patients aged <60 years, cancer patients aged ≥60 years had significant associations with alcohol-related cancer risk (MOR= 1.503, 95% CI: 1.029-2.196), alcohol-related heart disease (MOR = 3.015, 95% CI: 1.965-4.626), alcohol-related diabetes (MOR =2.300, 95% CI: 1.440-3.673), helping sleep (MOR =2.033, 95% CI: 1.267-3.263), and reducing anxiety (MOR =1.918, 95% CI: 1.218-3.021). Multiple cancers had limited moderating effects on the associations of sleep hours with outcomes of physical exercise and alcohol conditions. Socioeconomic factors (Coefficient=-0.311, 95% CI: -0.529, -0.094) and benefits of physical activity (Coefficient=-0.417, 95% CI: -0.737, -0.096) were mainly drivers of fair/poor SRH.

CONCLUSION: A high proportion of cancer patients are abnormal sleepers, insufficiently active and alcoholic. Socioeconomic factors and physical exercise were mainly drivers of health changes among them. Multiple cancers and sleep hours had limited effects on outcomes of physical exercise and alcohol conditions.
Моя будущая профессия — учитель информатики
Authors: Семенихин Е.
Published: July 2023

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Наука для принцесс
Authors: Ходан А.
Published: July 2023

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PEMILAH KOTAK SUSU OTOMATIS BERDASARKAN WARNA
Authors: Agusti Ananda Budi , Khamdi Nur , Jaenudin Jajang , Rahmawaty Made
Published: July 2023

Sebuah warna produk akan menggambarkan rasa dari sebuah rasa susu. Dalam pengemasan produk akan disesuaikan dengan satu warna atau satu rasa, maka dari itu dibutuhkan proses pemilahan produk berdasarkan warna produk atau rasa produk. Belakangan ini banyak bermunculan industri yang menciptakan produk-produk berkualitas, produk-produk ini kebanyakan menggunakan kemasan seperti kardus, namun proses pemilahan warna dilakukan secara manual. Pesanan produk yang sangat banyak tentunya akan sangat merepotkan apabila proses pemilahan masih dilakukan secara manual.  Maka dibuat Pemilah Kotak Susu Otomatis Berdasarkan Warna, dengan tinggi 40 cm, lebar 60 cm, panjang 75 cm, dikontrol dengan mikrokontroler Arduino dan sensor warna untuk bagian pemilahan warnanya dan ditampung di wadah yang sesuai dengan warna produk yang dideteksi sensor warna. Untuk pemilahan kotak dilakukan dengan meletakkan kotak(produk) pada konveyor yang melewati sensor warna TCS230, sehingga memisahkan susu berdasarkan warna kotak(produk) susunya. Proses berlangsung bila infrared pada tempat pendeteksi, mendeteksi adanya kotak atau produk yang akan melewati sensor warna TCS230 sesuai warna kotak susu (pink, coklat, dan biru). Jika tidak sesuai, maka kotak(produk) akan dilewatkan menuju ke kardus susu yang sesuai dengan warna kotak(produk) yang dideteksi sensor warna.Setelah dilakukan pengujian sebanyak 10 kali pengujian, pemilahan ketiga warna kotak menunjukkan tingkat keberhasilan 100%.

 

Kata kunci: Mikrokontroler, konveyor, sensor infrared, sensor warna TCS230
Pembuatan Struktur Tiga Dimensi Protein Nukleokapsid SARS-CoV-2 Menggunakan Pendekatan Bioinformatika
Authors: MAULANA GILANG , TAUFIQURROHMAN OPIK
Published: July 2023

Nukleoprotein merupakan protein yang terikat dengan asam nukleat, sedangkan nukleokapsid merupakan kapsid atau penutup materi genetik virus. Struktur protein dapat ditentukan dengan cara pengujian di laboratorium, namun dalam penentuannya diperlukan tahapan instrumentasi dengan biaya yang tinggi. Melalui metode in silico, penentuan struktur tiga dimensi protein dapat dilakukan dengan biaya yang lebih murah. Tujuan penelitian ini adalah memprediksi struktur tiga dimensi nukleokapsid SARS-CoV-2 dengan metode in silico. Metode yang digunakan pada penelitian ini adalah metode homologi menggunakan program Modeller. Hasil dari penelitian ini menunjukkan bahwa prediksi struktur tiga dimensi protein nukleokapsid SARS-CoV-2 menghasilkan nilai DOPE -21543 dengan persentase identiti sebesar 51,45%.
S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma
Authors: Wang Yanmeng , Muylaert Catharina , Wyns Arne , Vlummens Philip , De Veirman Kim , Vanderkerken Karin , Zaal Esther , Berkers Celia , Moreaux Jérome , De Bruyne Elke , Menu Eline
Published: July 2023

Multiple Myeloma (MM) is the second most prevalent hematological malignancy and is incurable due to the inevitable development of drug resistance. The methionine adenosyltransferase 2α (MAT2A) is the primary producer of the methyl donor S-adenosylmethionine (SAM) and several studies reported MAT2A deregulation in different solid cancers. As the role of MAT2A in MM is not studied yet, the aim of this study was to clarify the potential role and underlying molecular mechanisms of MAT2A in MM, exploring new therapeutic options to overcome drug resistance. By analyzing publicly available gene expression profiling data, MAT2A was found to be highly expressed in patient-derived myeloma cells compared to normal bone marrow plasma cells (BMPC), correlating with an unfavorable prognosis in relapsed patients. MAT2A inhibition in MM cells led to a reduction in intracellular SAM levels, which resulted in impaired cell viability and proliferation and induction of apoptosis. Further mechanistic investigation demonstrated that MAT2A inhibition inactivated the mTOR-4EBP1 pathway, accompanied with a decrease in protein synthesis. MAT2A targeting in vivo with the small molecule compound FIDAS-5 was able to significantly reduce tumor burden in the 5TGM1 model. Finally, we found that MAT2A inhibition can synergistically enhance the anti-MM effect of the standard-of-care agent bortezomib both on MM cell lines and primary human CD138+ _MM cells. In summary, we demonstrate that MAT2A inhibition reduces MM cell proliferation and survival by inhibiting mTOR-mediated protein synthesis. Moreover, our findings suggest that the MAT2A inhibitor FIDAS-5 could be a novel compound to improve bortezomib-based treatment of MM.
FREQUENCY OF POST DURAL PUNCTURE HEADACHE WITH 25G QUINCKE NEEDLE IN PATIENTS SCHEDULED FOR ORTHOPAEDIC SURGERY UNDER SPINAL ANAESTHESIA
Authors: Tayyeb Muhammad , Arsalan Muhammad , Arshad Ullah Syed , Ali Waqar , Maluik Salman , Uddin Iftikhar , Khuzayiah Siti
Published: July 2023

Objectives: To determine PDPH frequency among patients scheduled for orthopaedic surgeryafter spinal anaesthesia with a 25G Quincke needle.Materials and Methods: A 25-G Quincke needle was used to give standard spinal anaesthesia. The participant was 196 patients who underwent orthopaedic surgery at Mardan MedicalComplex. The study enrolled all patients who met the inclusion criteria. Patients with infectiousdiseases, coagulopathy, severe hypovolemia elevated intracranial pressure were excluded fromthis study. On postoperative days the patients were examined for the existence, features, andseverity of headache. Only posture-dependent headaches were classifi ed as PDPH, with severitylevels ranging from mild to severe.Results: The mean age of observed participants was 41.17 (± 15.5). The prevalence of PDPHafter administering 25G Quincke spinal needles was 29.5% (58/196. Mild PDPH was observed in32(55.1%) patients, in 23 (39.6%) patients moderate and severe in 3(5.1%) patients. It appearedin the majority of PDPH patients during the fi rst and second postoperative days. There was asignifi cant (p<0.05) association between PDPH status and the number of attempts to obtainCerebrospinal Fluid.Conclusion: When a 25G Quincke spinal needle was used, the frequency of PDPH was substantially higher. The low rate of severe headaches and the number of attempts to acquire CSF aff ectthe status of PDPH.
Post-SARS-CoV-2 Multisystemic Syndrome in the Paediatric Population of Pakistan: A Case Report
Authors: Bibi Fazeela , Nayyer Fatima , Zehra Maham , Jabeen Sara
Published: July 2023

A rare life-threatening condition has been noticed in children who have been previously infected with COVID-19, involving organ inflammation, named as a multisystem inflammatory syndrome. In this study, the authors analyse a unique case, describe possibilities of disease manifestation in a particular individual, and detail different treatment options. Along with treatment and monitoring, all eligible children should be vaccinated against COVID-19. Unfortunately, due to decreased availability and increasing demand for the COVID-19 vaccine, the government in Pakistan has been led to vaccinate the general population on the basis of age group. Currently, individuals older than 12-years-old are being vaccinated, but not those who are younger. As a result, younger children have a higher chance of being infected with COVID-19 and developing multisystem inflammatory syndrome in children (MIS-C). Vaccination against the virus reduces the likelihood of COVID-19 infection. MIS-C is a rare condition found in children that might be fatal, and current evidence indicates that MIS-C occurs due to exaggerated immune response.
The effect of PVD layout on the consolidation characteristics of dredged slurry under vacuum preloading
Authors: Cai Jing , He Zili , Xu Bin , Yu Mengfei
Published: July 2023

Vacuum preloading coupled with prefabricated vertical drains (PVDs) has been widely used to improve the property of the dredged slurry. However, the effect of PVD layout on slurry consolidation characteristics remains poorly understood. This study conducted two vacuum preloading model tests—with single and dual PVDs. Particle image velocimetry (PIV) was used to directly observe the slurry displacements and strain paths. The test results revealed that the slurry consolidation characteristics were similar under different PVD layouts in the early stage of vacuum preloading. However, in the mid-stage, the effect of dual PVDs led to a significant reduction and increased dispersion of the slurry horizontal displacement. This, in turn, resulted in a thinner clogging zone and a subsequent decrease in vacuum pressure loss. Consequently, the slurry near the PVDs experienced an extended period of consolidation deformation. During the later stage, the single PVD model test exhibited a distinct zone of both vertical and horizontal compression in the slurry, while under dual PVDs, the slurry primarily underwent vertical compression and horizontal extension. The study also provided the relationship between the clogging zone thickness and time, which provided a reference for theoretical consolidation calculations.
Distinctive visual tasks for characterizing mild cognitive impairment and dementia using oculomotor behavior
Authors: Rane Dharma , Dash Deba Prasad , Dutt Alakananda , Dutta Anirban , Das Abhijit , Lahiri Uttama
Published: July 2023

Introduction

One’s eye movement (in response to visual tasks) provides a unique window into the cognitive processes and higher-order cognitive functions that become adversely affected in cases with cognitive decline, such as those mild cognitive impairment (MCI) and dementia. MCI is a transitional stage between normal aging and dementia.

Methods

In the current work, we have focused on identifying visual tasks (such as horizontal and vertical Pro-saccade, Anti-saccade and Memory Guided Fixation tasks) that can differentiate individuals with MCI and dementia from their cognitively unimpaired healthy aging counterparts based on oculomotor Performance indices. In an attempt to identify the optimal combination of visual tasks that can be used to differentiate the participant groups, clustering was performed using the oculomotor Performance indices.

Results

Results of our study with a group of 60 cognitively unimpaired healthy aging individuals, a group with 60 individuals with MCI and a group with 60 individuals with dementia indicate that the horizontal and vertical Anti-saccade tasks provided the optimal combination that could differentiate individuals with MCI and dementia from their cognitively unimpaired healthy aging counterparts with clustering accuracy of ∼92% based on the saccade latencies. Also, the saccade latencies during both of these Anti-saccade tasks were found to strongly correlate with the Neuropsychological test scores.

Discussion

This suggests that the Anti-saccade tasks can hold promise in clinical practice for professionals working with individuals with MCI and dementia.
Effects of cholesterol-lowering probiotics on non-alcoholic fatty liver disease in FXR gene knockout mice
Authors: Yang Minghua , Wang Haoyang , Bukhari Ihtisham , Zhao Ye , Huang Huang , Yu Yong , Sun Xiangdong , Mi Yang , Mei Lu , Zheng Pengyuan
Published: July 2023

Background/aims

Some studies showed that probiotics could improve the composition and structure of gut microbiota. Changes in the gut microbiota may alter bile acid (BAs) composition and kinetics, improving non-alcoholic fatty liver disease (NAFLD). However, it still needs to be clarified how probiotics improve both the metabolism of BAs and NAFLD. This study aimed to reveal the regulatory mechanisms of cholesterol-lowering (CL) probiotics on NAFLD from aspects involved in BA metabolism in FXR gene knockout (FXR−/−) mice.

Methods

FXR−/− male mice were randomly divided into three groups based on different interventions for 16 weeks, including normal diet (ND), high-fat diet (HFD), and probiotic intervention in the HFD (HFD+P) group. 16s rDNA sequencing and ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) were utilized to analyze the changes in gut microbiota and fecal bile acids in mice.

Results

We found that the intervention of the CL probiotics improved liver lipid deposition and function in HFD-induced NAFLD mice by decreasing the levels of total cholesterol (TC; p = 0.002) and triglyceride (TG; p = 0.001) in serum, as well as suppressing liver inflammation, such as interleukin-1 beta (IL-1β; p = 0.002) and tumor necrosis factor-alpha (TNF-α; p < 0.0001). 16S rDNA sequencing and metabolomic analyses showed that probiotics effectively reduced the abundance of harmful gut microbiota, such as Firmicutes (p = 0.005), while concomitantly increasing the abundance of beneficial gut microbiota in NAFLD mice, such as Actinobacteriota (p = 0.378), to improve NAFLD. Compared with the ND group, consuming an HFD elevated the levels of total BAs (p = 0.0002), primary BAs (p = 0.017), and secondary BAs (p = 0.0001) in mice feces, while the intervention with probiotics significantly reduced the increase in the levels of fecal total bile acids (p = 0.013) and secondary bile acids (p = 0.017) induced by HFD.

Conclusion

The CL probiotics were found to improve liver function, restore microbiota balance, correct an abnormal change in the composition and content of fecal bile acids, and repair the damaged intestinal mucosal barrier in mice with NAFLD, ultimately ameliorating the condition. These results suggested that CL probiotics may be a promising and health-friendly treatment option for NAFLD.
Convergence of Collocation Methods for One Class of Impulsive Delay Differential Equations
Authors: Wang Zhiwei , Zhang Guilai , Sun Yang
Published: July 2023

This paper is concerned with collocation methods for one class of impulsive delay differential equations (IDDEs). Some results for the convergence, global superconvergence and local superconvergence of collocation methods are given. We choose a suitable piecewise continuous collocation space to obtain high-order numerical methods. Some illustrative examples are given to verify the theoretical results.
Effect of Thermoresponsive Xyloglucan on the Bread-Making Properties and Preservation of Gluten-Free Rice-Flour Bread
Authors: Fujii Keiko , Usui Momomi , Ohsuga Akiko , Tsuji Michiko
Published: July 2023

This study clarified the effect of adding thermoresponsive xyloglucan on the bread-making properties and preservation of gluten-free rice-flour bread. The thickening polysaccharides used for preparing gluten-free rice-flour bread were modified tamarind gum (MTG; thermoresponsive xyloglucan), tamarind gum (TG), and xanthan gum (XT). The mechanical properties of the added polysaccharide thickener solutions and bread dough, the mechanical properties and sensory characteristics of rice-flour bread, and the aging properties of rice-flour bread were measured. The results showed that the MTG solution exhibited solification at 40 °C and gelation below 40 °C, which affected the dynamic viscoelasticity of the dough. The addition of MTG to gluten-free rice-flour bread reduced the specific volume, increased the moisture content, and reduced the stress at 70% compression. Therefore, the bread with MTG added was soft, moist, and preferred over other those with other additives. In terms of preservation, the addition of 0.5–0.75% of polysaccharides inhibited the hardening and aging of beard with MTG added. This indicates that the addition of MTG at low concentrations is effective in preserving gluten-free rice-flour breads. We found that the thickening polysaccharides had to be added in appropriate concentrations to improve the bread-making properties and achieve the preferred effect.
Sustainable Aquaculture in the North Central Region U.S.—A Review of Perceptions and Recommendations from the Aquaculture Community
Authors: Weeks Chris
Published: July 2023

Aquaculture remains the fastest growing food commodity in the world and is expected to have an important role in food security in the future. However, for the aquaculture industry to grow, it must do so in a sustainable manner. From an Extension standpoint, this presents many challenges. This article discusses the concept of sustainable aquaculture and how it is perceived regionally and presents a model that allows for increased focus towards three principle components: environmental conservation, social benefits, and economic viability. This article seeks to help further dialogue towards sustainable aquaculture and other industry development in the U.S.
EXAMINING THE AWARENESS OF MUSLIM CONSUMERS TOWARDS HALAL FOOD
Authors: Ibrahim Ima Ilyani , Md Nor Mohamad Niza , Ahmad Zulaiha , Mohd Razali Mohd Fazly , Mansor Zulkafli
Published: July 2023

Due to its recognition as a Muslim country, Malaysia has used this status to establish itself as a global hub for halal products. As the majority population of Malaysia are Muslims, who are also major consumers of halal food, they are expected to have a deeper understanding of the concept compared to other ethnic groups. Despite the majority being Muslim, many foods are still not prepared according to halal regulations, and there are abundant issues with abuse of halal certification and labelling. This study aims to investigate the awareness of halal food among Muslim consumers. The study examines the impact of variables such as halal logo labelling and packaging, exposure to regulatory authorities and enforcement, and consumer attitudes by using a questionnaire distributed to respondents in Northern Malaysia. Statistical Package for Social Science (SPSS) was utilized for data analysis, and multiple regressions were conducted to test the hypothesis. The results of the study indicate mixed results in relation to the tested relationship between the variables. Based on the research, there is a significant relationship between the halal logo, labelling and packaging, regulatory authorities’ exposure and enforcement, and consumer attitude of customer awareness towards halal food among Muslims in Malaysia.
A survey of superpixel methods and their applications
Authors: Wu Chong , Yan Hong
Published: July 2023

Superpixels can preserve the structure and reduce the redundancy of the
original image. Because of these advantages, superpixel generation or
superpixel segmentation is widely used as a pre-processing step in many
image processing tasks. Although superpixels can be employed to reduce
computational complexity, some challenges, such as the non-Euclidean
feature learning problem introduced by superpixels, still exist. This
survey provides a comprehensive overview of the state-of-the-art
superpixel methods, major challenges, commonly used evaluation metrics,
applications of superpixels, and potential future directions for the
study of superpixels. We first give a review of the state-of-the-art
superpixel methods. Next, we use different evaluation metrics to
evaluate the performance of 24 up-to-date superpixel methods on
different datasets in different noisy environments. After that, we
introduce several up-to-date applications of superpixels. Finally, we
give several possible future directions for addressing the challenges of
superpixels.
Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts from High-density Multielectrodes
Authors: Pancorbo Lucía , Ruiperez-Campillo Samuel , Tormos Álvaro , Guill Antonio , Cervigón Raquel , Alberola Antonio , Chorro Francisco Javier , Millet Jose , Castells Francisco
Published: July 2023

 High-density multielectrode catheters are becoming increasingly popular in cardiac electrophysiology for advanced characterisation of the cardiac tissue, due to their potential to identify impaired sites. These are often characterised by abnormal electrical conduction, which may cause locally disorganised propagation wavefronts. To quantify it, a novel heterogeneity parameter based on vector field analysis is proposed, utilising finite differences to measure direction changes between adjacent cliques. The proposed Vector Field Heterogeneity metric has been evaluated on a set of simulations with controlled levels of organisation in vector maps, and a variety of grid sizes. Furthermore, it has been tested on animal experimental models of isolated Langendorff-perfused rabbit hearts. The proposed parameter exhibited superior capturing ability of heterogeneous propagation wavefronts compared to the classical Spatial Inhomogeneity Index, and simulations proved that the metric effectively captures gradual increments in disorganisation in propagation patterns. In particular, it provided robust and consistent results for given with 4 × 4 grid sizes, which makes it suitable for new-generation orientation-independent cardiac catheters. 
Humor pré-competitivo em atletas brasileiros de jiu-jitsu
Authors: Brandt Ricardo , Hobold Edilson , Viana Maick da Silveira , Dominski Fábio Hech , Bevilacqua Guilherme Guimarães , Turczyn Bruna
Published: July 2023

O presente estudo teve por objetivo avaliar os estados de humor e fatores associados de atletas brasileiros de jiu-jitsu antes da participação em competição. Foram avaliados 84 atletas do sexo masculino com idade média de 29,1 anos (±6,5). Os instrumentos utilizados foram a Escala de Humor de Brunel e um questionário de caracterização dos participantes. A coleta dos dados foi realizada durante um campeonato internacional. Para análise dos dados, utilizaram-se os testes de Mann-Whitney e Kruskal-Wallis. Os atletas apresentaram baixa confusão, depressão, raiva e fadiga, tensão moderada e alto vigor. A auto avaliação da saúde e a satisfação com o peso se associaram à confusão, quanto melhor a auto avaliação da saúde do atleta, menor a sua confusão. Atletas que estão satisfeitos ou gostariam de diminuir seu peso apresentaram confusão maior do que aqueles que gostariam de aumentar. A qualidade de descanso se associou à confusão, raiva, depressão e vigor. Quanto menos descansado o atleta se sente, maior sua depressão, raiva e confusão; quanto mais descansado o atleta, maior o seu vigor. Em relação à qualidade do sono, houve uma associação com a confusão, vigor e depressão. Quanto pior a qualidade do sono, maior a confusão e depressão, e quanto melhor a qualidade maior é o seu vigor.
ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Мусаев А.А. , Гайрабекова М.Х.
Published: July 2023

В данной статье идет разбор сущности и значения экономической безопасности РФ. Перечислены основные угрозы и методы повышения экономической безопасности. Актуальность экономической безопасности России неоспорима, так как она влияет на процветание страны, а также на доступность ресурсов для граждан. Целью данной работы является изучение существующего состояния экономической безопасности России и предложение способов для ее укрепления. В целях данного исследования будут использоваться анализ и наблюдение существующих данных. Тема экономической безопасности России до сих пор достаточно недооценена, поэтому подход автора заключается в предложении идей для усиления экономической безопасности России и обеспечения долгосрочного процветания экономики страны. Авторский подход к данной теме включает анализ существующей проблемы и выявления способов обеспечения процветания экономики и устойчивости страны.
On a class of analytic functions closely related to starlike functions with respect to a boundary point
Authors: Dhurai Kamaraj , Cho Nak Eun , Sivasubramanian Srikandan
Published: July 2023

In this article, we introduce a new class of analytic functions in the open unit disc that are closely related to functions that are starlike with respect to a boundary point. For this new class of functions, we obtain representation theorem, interesting coefficient estimates and also certain differential subordination implications involving this new class.
Sea Queens
Authors: Geer Brendan , Brown Jon
Published: July 2023

Narratives, as one of the oldest cultural and didactic traditions known to humankind, trace back across numerous civilizations, societies, and histories. At educational institutions, narratives are interdisciplinary and allow for an interactive, cross-competence study of school subjects. However, direct instruction-based methodologies tend to limit student interaction with narrative-based learning. In response to this problem, Turkish professors Gurses, Dogar, and Gunes established a direct constructivist learning model that changed two-dimensional direct instruction to a three-dimensional model. In this chapter, the authors contend that a direct model is insufficient to create LGBTIQ+ inclusiveness; so, they propose an indirect interaction model for narratives in multidisciplinary fields by making use of the figure of an avatar as developed in game studies. They then offer several practical applications of the indirect-interaction-based model to inclusive narratives, and they conclude by emphasizing the game-like nature of a narrative-based inclusive classroom design.