bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia
Authors: Uhal Bruce D
Published: February 2023

Premature birth results in an increased risk of respiratory distress and often requires oxygen therapy. While the supplemental oxygen has been implicated as a cause of bronchopulmonary dysplasia (BPD), in clinical practice this supplementation usually only occurs after the patient’s oxygen saturation levels have dropped. The effect of hyperoxia on neonates has been extensively studied. However, there is an unanswered fundamental question: which has the most impact- hyperoxia, hypoxia or fluctuating oxygen levels? In this review, we will summarize the reported effect of hypoxia, hyperoxia or a fluctuation of oxygen levels (hypoxia/hyperoxia cycling) in preterm neonates, with special emphasis on the lungs.
Mix-and-match COVID-19 vaccination: a proper strategy for countries of COVID-19 vaccine shortage
Authors: Cheepsattayakorn Attapon
Published: February 2023

A comprehensive search was carried out in mainstream bibliographic databases or Medical Subject Headings, including ScienDirect, PubMed, Scopus, and ISI Web of Science. The search was applied to the articles that were published between January 2021 and November 2021. With strict literature search and screening processes, it yielded 10 articles from 136 articles of initial literature database. In June 2021, a preliminary study conducted by the University of Oxford scientists demonstrated that mixing the AstraZeneca and Pfizer vaccines produced a robust immune response against the SARS-CoV-2 (COVID-19) virus and induced higher antibodies than an only two-dose schedule of AstraZeneca vaccine and none of the groups demonstrated decreased neutralizing activity against the Alpha variant (UK variant), but the neutralization titer reduced by 2.5 to 6times against the Beta variant (South African variant), Gamma variant (Brazilian variant), and Delta variant (Indian variant). The Comparing COVID-19 Vaccine Schedule Combinations (Com-COV) study (463 cases of the 4-week interval group) revealed that immunization with AstraZeneca vaccine followed by Pfizer vaccine at the 4-week interval demonstrated a better immune response out of the two mixed dosing regimens. Com-COV study demonstrated in the earlier phase that around 30 % to 40 % of those who received mixed doses reported fevers after their second jab, compared to 10 % to 20 % of those who received the same vaccine for both doses. This result could be attributable to the shorter, 4-week interval between doses that was used during the Oxford study, whereas the safety data from a cohort with a 12-week dosing interval is still to appear. In conclusion, it is better to give a different COVID-19 vaccine or mix-and-match COVID-19 vaccination than not administer the second dose at all.
No protection seen on challenge with live virus after single intranasal immunization with heat inactivated virus in murine model of EHV-1 infection
Authors: Awan Aftab
Published: February 2023

Equine herpes virus (EHV-1) causes respiratory disease, abortion, neonatal death, paresis, retinopathy, and latent infection and is wide-spread among equine worldwide. Horses show transient immunity after natural or experimental EHV-1 infection and immune responses to EHV-1 begin to decline after a few months after infection. As a result, recovered horses are prone to subsequent EHV-1 infection. Due to transient immune responses, effective and lasting vaccination remains a challenge. As this virus is widespread among equine, development of effective vaccine is a challenge. We used a murine model to study the efficacy of heat inactivated virus in terms of protection in a challenge study. After 34 days following intranasal inoculation with heat inactivated virus, mice were challenged with live virus along with previously placebo control group. Clinical signs, virus titres, and viraemia were studied in both groups. We noticed that mice on challenge showed more clinical signs at peak of infection but no significant difference in virus titres and infectious centre assay was noted. The results of this study suggest that heat inactivated virus does not provide any protection to challenge dose but in fact these group looked clinically worse. These results are discussed along with the possible mechanism involved in more clinical signs seen on challenge after single dose of intranasal immunization by heat inactivate virus in current communication.
Comparison of different types of vape products on vital signs following twenty minutes of vaping and exposure to vapor
Authors: McClelland Molly L
Published: February 2023

Introduction: Vaping continues to rapidly expand as an alternative to cigarette use and a novel tobacco-free inhalation device. The electronic devices are filled with e-juice which is heated, vaporized, and inhaled. There are a plethora of flavors and nicotine concentrations that can be added to the vegetable glycerin, and propylene glycol base liquid found in e-juice. Methods: 279 participants were divided into four groups varied according to type of e-juice. Two groups were given e-cigarettes to use, one group had no flavoring or nicotine added to the e-juice, the other group had mint flavoring and 5% nicotine added to the e-juice. The third and fourth groups were exposed to the vapor of the aforementioned types of e-juice. Participants vaped or were exposed to vapor for 20 minutes. A set of vital signs were obtained before and after the vaping sessions. Results: People vaping with mint-flavored e-juice with 5% nicotine have significant reductions in their oxygen saturation, but significant increases in blood pressure, heart rate and respiratory frequency compared to their non-vaping counterparts, or those vaping without mint flavored nicotine e-juice. Participants exposed to vapor with and without nicotine or mint flavors had significantly reduced blood pressures compared to people vaping mint-flavored e-juice with 5% nicotine. Conclusion: Vaping with mint-flavored e-juice with 5% nicotine for twenty minutes has a significant negative impact on vital signs. Exposure to vapor does not have the same effect on vital signs regardless of the contents of the e-juice. Implications: Health care providers should assess for vape use in their patients. Law makers should also be made aware of the physiological impacts of vaping different types of e-juice and exposure to vapor, and make informed policies and decisions regarding vape use. Vaping, especially with certain flavors and nicotine concentrations, is not a safe alternative to cigarette smoking, however, exposure to second-hand vapor does not appear to have significant immediate effects on vital signs.
Non-small cell lung cancer: news from immunotherapy
Authors: Maheshwary Neeta
Published: February 2023

This study examines the use of different vaccines and therapies for treating non-small lung cancer. The research is focused on immunotherapy to treat lung cancer that affects a large number of people globally. The research used literature review to gather data, and the results were examined thematically to present the most effective methods for treating this medical issue. The results of the study found that lung cancer can be treated effectively through different immunotherapy techniques.
The role of interleukin-6 and janus kinases in the pathogenesis, and treatment of SARS-CoV-2
Authors: Syabbalo Nightingale
Published: February 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a deadly pneumonia caused by an enveloped, single-stranded RNA betacoronavirus belonging to the coronaviridae family. Pathophysiologically, SARS-CoV-2 is due to severe hyperinflammatory host response to the coronavirus, resulting in overproduction of cytokines, chemokines, and growth factors by macrophages, such as interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10, and tumour necrosis factor-α. SARS-CoV-2 is characterized by diffuse alveolar damage due to direct infection of alveolar type II pneumocytes, pulmonary edema, vascular occlusion, interstitial infiltrates, and ventilation/perfusion mismatch, which rapidly progress to hypoxemia, acute respiratory distress syndrome, multi-organ failure, and death. The standard of care of Covid-19, includes high-flow nasal oxygen (HFNO), dexamethasone, remdesivir, and mechanical ventilation or extracorporeal membrane oxygenation in very severe cases. However, the mortality is exceptionally high even with these therapies. Covid-19 is due to dysregulation, and over-production of cytokines, including IL-1β, IL-6, IL-10, and TNF-α. IL-6 plays a key role in orchestrating the hyperinflammation and the cytokine storm, which leads to acute lung injury, respiratory failure, and multi-organ failure. Interleukin-6 signaling is via the transmembrane IL-6 receptor-α (mIL-6Rα), and the soluble IL-6Rα. Tocilizumab, and sarilumab are IL-6Rα antagonists, and have been issued an emergency use authorization (EUA) by the FDA. Both biologics are safe, and effective in the treatment of severe Covid-19, particularly in patients requiring HFNO, and respiratory support. Another therapeutic approach to treat Covid-19 is to target the downstream JAK/STAT pathway which plays a critical role in inciting IL-6 immunopathological effects. Baricitimab and tofacitinib have been granted EUA by the FDA. A systemic review has shown that JAK-inhibitors significantly decrease odd of mortality (P ˂ 0.0005), and ICU admission (P ˂ 0.0005). Additionally JAKinibs significantly increase odds for patient discharge within 2 weeks P ˂ 0.00001). Tofacitinib has been reported to lead to a lower risk of respiratory failure or death through day 28 than placebo in hospitalized patients with Covid-19. Barictinib in addition to standard of care, including dexamethasone was associated with reduced mortality in hospitalized adults with Covid-19. Selective JAK inhibitors in addition to usual care are effective in the treatment of patients with Covid-19.
Analysis of body balance assessment results at posturography: an integrative review
Authors: Brock Camila Martins , Carmona Sergio , Hochhegger Bruno
Published: February 2023

Background: Posturography objectively assesses the central management of integrated peripheral sensory information (visual, vestibular, and proprioceptive) and the sensorimotor response required for balance. Recently published articles show the peculiarity of the currently available posturography devices and the variety of postural responses found. Aim: The goal of this integrative review is to analyze the confluence between the outcomes of different studies involving adults and elderly patients with no instability complaints evaluated at posturography. Methods: Of the 39 articles evaluated for eligibility, 9 articles met the criteria of this literature review. All studies included elderly patients (≥65 years). The posturography devices used were: NeuroCom®, Nintendo® Wii, and Bertec®. Results: The objective data provided by posturography differ as regards the calculation of the oscillatory trajectory and the tests performed. Postural instability was significant under different conditions among the articles. Conclusion: The final outcome analysis of the different studies showed that age and healthy aging result in modifications in posturography. Keywords: posturography, healthy aging, postural balance
Early activation of a late sequential cochlear implant systematic review
Authors: Torre LM Niño , Montoya SR Rodríguez
Published: February 2023

Early activation of Cochlear Implant (CI) is a technique where the processor is activated in less than 4 weeks. In this way, time and costs are reduced in the process of functional restoration of hearing. On the other hand, a late sequential cochlear implant is one where the second CI is implanted at a different surgical time than the first and the user's age is greater than 7 years. The aim of systematic review is to analyze the available information on the effects of early activation after late sequential cochlear implant surgery. Systematic literature search was performed, in databases, of studies about the effects of early activation of late sequential CI and early activation of CI in terms of quality of life, hearing and language from the years 2012 to June 2022. Fifteen publications were included in the clinical evidence review for early CI activation review, but no articles were found for review on the topic of early activation of late sequential CI. The review identified early CI activation as a safe and reliable procedure where the effects are positive on quality of life, hearing and speech by electrophysiological and auditory perceptual recordings. However, no information about the effects on early activation of late sequential CI is recognized. Keywords: early activation, cochlear implant, sequential, late, impedance, complications
Esophageal foreign bodies
Authors: Delgado Juan Ivonne , Alfredo Luis , Regalado Rodríguez
Published: February 2023

Esophageal foreign bodies are a relatively frequent emergency in our country and their removal is necessary as quickly as possible to avoid complications and suppress the discomfort they cause to patients, so an emergency esophagoscopy is performed by the Otolaryngology Specialist who is is on duty, so all otolaryngologists must know this entity and have experience in the diagnosis and performance of the surgical technique for its extraction, wanting with this exhibition to contribute to have a better knowledge of this entity. Keywords: foreign body, esophagus, dysphagia
Comparison of third-party disability between normal hearing siblings of children using hearing aids and those using cochlear implants
Authors: Rani Manisha , Nandurkar Aparna
Published: February 2023

Purpose: Historically, research tends to focus on the experiences of deaf children and the difficulties faced, as well as the difficulties their parents endure. Less attention has been focused on siblings of children with hearing impairment (CWHI). This study aimed to compare the Third-Party Disability between normal hearing siblings of children using hearing aids (HAs) with those using cochlear implants (CI). The objective was to develop International Classification of Functioning, Disability and Health (ICF) based-tools across different domains and categories that describe third-party disability in siblings of children with hearing impairment. Method: 45 Normal Hearing Older Siblings (NHOS) from the two groups of children with hearing impairment using HAs and CI participated in the study. A tool was developed and mapped onto ICF components of Activities and Participation and Environmental factors. The developed tool consisting of 43-items across six-domains was administered through interviews, independent of the sibling. Frequency distribution and descriptive statistics were obtained. Shapiro-Wilk test was performed to assess normality of the distribution. Mann Whitney U test was administered to compare the domain-wise distributions for the two groups. Results: NHOS of CWHI using HAs perceive greater third-party disability as compared to the NHOS of CWHI using unilateral CI across all the six domains included in the study. The differences were striking in the domain of communication, interpersonal interaction and relationship, support and relationship. There were differences across the other three domains which were not found to be statistically significant. Conclusion: Hearing loss is a disabling condition that not only effects the individual, but is an experience shared by immediate family members including siblings. The extent of third-party disability in NHOS is influenced by the hearing device. This study has provided insights into the difficulties faced by normal hearing siblings of children with hearing impairment. Implication: Utilization of an ICF-based tool has provided an idea about the specific domains(s) in which they perceive maximum difficulties, which will help clinicians counsel parents, focusing not only on the needs and issues of the CWHI but also the hearing siblings. Keywords: children with hearing aids, children with cochlear implants, normal hearing siblings
Comparison between reading comprehension and phonetic and non-phonetic reading skills in children with normal hearing and children with cochlear implants
Authors: Arora Chandni , Nandurkar Aparna
Published: February 2023

The primary purpose of this study was to explore the reading comprehension skills and phonetic and non-phonetic reading skills in the English language in both, children with normal hearing and children with cochlear implantation. Research in this area is limited with respect to the Indian context and hence a study dealing with these aspects has the potential to broaden our understanding of benefits of cochlear implantation as it helps with academics. The study involved a total of 74 participants across three grades, 5th, 6th and 7th of which 57 were CWNH and 17 were CWCI. All were assessed based on scores attained on 4 assessment tasks, phonetic reading skills, non-phonetic reading skills, short reading passage comprehension and long reading passage comprehension. On statistical analysis, there was a significant difference between scores obtained on phonetic reading, short reading passage comprehension and long reading passage comprehension between 5th and 6th as well as 6th and 7th graders of CWNH. However, no significant difference was recorded between all three standards (5th, 6th and 7th) on all 4 assessment tasks for CWCI group. When grade level comparisons were made between CWNH and CWCI, there was no statistically significant difference of scores on any of the 4 tasks between the two groups at any grade level except that 6th graders of CWNH group performed better in the short reading passage comprehension task as compared to 6th graders of CWCI. Keywords: cochlear implant, reading comprehension, phonetic words, non-phonetic words
Evaluation of MRI and transnasal endoscopic surgery for the diagnosis of perineural tumor spread to the skull base
Authors: Tepedino Miguel Soares , Costa Silva Camila Alves , Figueiredo Neves Raíssa de , Costacurta Andrea S D , Junqueira Mariana Mafra , Herchenhorn Daniel , L Dias Fernando
Published: February 2023

Introduction: Magnetic resonance imaging (MRI) provides information about tumor size and extension, infiltration of major blood vessels and nerves, early bone-marrow infiltration, and lymph node involvement. Transnasal endoscopic approaches are an integral part of the therapeutic arsenal developed to address malignant sinonasal and skull-base neoplasms. Objective: To analyze the use of magnetic resonance imaging in the diagnosis of perineural tumor spread involving the skull base region. Methods: We describe two cases of patients who presented with primary squamous cell carcinoma in the malar region and suspected perineural spread to the skull base on MRI. One frozen cadaver head, were dissected to expose the trigeminal nerve and it branches. Results: MRI showed evidence of perineural spread to the skull base, which was confirmed histopathologically after endoscopic transnasal biopsy. Conclusion: MRI plays an important role in the diagnosis of perineural spread of tumors originating in the nose and skull base. In the two cases reported herein, the diagnostic suspicion raised by MRI was confirmed by histopathological examination. Endoscopic transnasal skull base surgery proved to be an important tool for diagnostic confirmation, with low procedure-associated morbidity. The presence of perineural spread changes the staging and, consequently, the prognosis and treatment of these tumors. Thus, its active search should be encouraged to improve diagnosis and help ensure appropriate treatment. Keywords: endoscopic surgery, magnetic resonance imaging, perineural tumor, bone-marrow infiltration
VOR Cancellation at the patient's bedside: how to avoid another cause of false positive
Authors: D’Albora – Rivas Ricardo , Luis Cuervo José , Silvera Ligia , Monaco – Hansen María Julia , Zalazar Guilermo , Carmona Sergio
Published: February 2023

There is little literature on the semiological aspects of the clinical Vestibulo-Occulomotor Reflex (VOR) cancellation technique. This study aims to determine which would be the best head movement frequency cutoff to perform the VOR cancellation clinical test. Materials and methods: 98 horizontal semicircular canals with normal gains from normal individuals were included. The VOR was cancelled by placing a headband with a fixed target over the individual's head, and the patient was told to keep their eyes on the target while the examiner recorded the presence and number of saccades that were evident with the naked eye by performing sinusoidal cephalic rotations at different frequencies. The head rotation frequency was compared with the following variables: 1-Saccades that are evident with the naked eye -SHIMP (+) clinical-, 2-The presence of saccades performed for a period of 2 seconds, 3- The presence of saccades performed in every cycle, 4- Amplitude in º/sec. of the performed saccades, 5-Percentage of VOR cancellation and 6-Age. Conclusion: To avoid a false positive caused by SHIMP saccades during the clinical evaluation of the VOR cancellation at the patient's bedside, we recommend performing cephalic rotations with frequencies lower than 0.5Hz - 0.6Hz for the age group under 67 years old. In patients older than and equal to 67 years old, the interpretation of the VOR cancellation using this method should be cautious, and it should be performed with glasses if worn. Keywords: vestibulo-cular reflex cancellation, SHIMP saccades, SHIMP headband
Clinical features and management of pediatric patients with primary immune thrombocytopenia in a secondary care hospital in Northwest Mexico
Authors: Elena Haro Acosta Maria , Manuel Hurtado Llamas Rey , Dautt Silva Joan
Published: February 2023

Introduction: Primary Immune Thrombocytopenia (PIT) is considered the most common immune hematologic disorder in children and represents a risk of morbid mortality. Despite it being a common diagnosis, its epidemiological characteristics have not been studied in our hospital. Objective: To determine the clinical and laboratorial characteristics of pediatric patients with PIT treated by the hematology service over a period of four years. Material and methods: This study was a retrospective analysis of pediatric patients with PIT who attended at the hematology service from 2014 to 2018 in the Gyneco-Obstetrics and Pediatric Hospital No. 31 in Mexicali, Baja California, Mexico. Medical history, clinical manifestations, laboratory results, treatment and therapeutic response, as well as recurrence and PIT classification were analyzed from their clinical files. Descriptive statistics was used, with measures of central tendency, percentages and frequencies with the SPSS v25 program. Results: A total of 57 patients were studied. The mean of age was 6.8±4.2 years, newly diagnosed PIT was present in 93.0% (n=53). The majority of patients were managed with observation alone (40.4%, n=23). The most frequent pharmacological managements used were intravenous immunoglobulin (29.8%) and steroids (19.3%). Recurrence was present in 12% of cases; 7% developed chronic PIT. Conclusion: The pattern of clinical and laboratory characteristics observed in this study are mostly similar to national and international literature. A remarkable finding was the few cases of chronic PIT.
Distribution of urinary schistosomiasis among school children at elkeriab and tayba elkababish villages, East Nile Locality, Khartoum State, Sudan
Authors: HashimTaha Qutoof , Hafiz Elshazali Osama , Ibrahim Ahmed Abubakr
Published: February 2023

Introduction: Schistosoma infection is a one of the main infection in the tropics and sub tropics, from a global public perspective Schistosoma is the most important water based disease, only second to malaria among the parasitic diseases with regard to the number of people infected and those at risk. The reported incidence of S.haematobium in Sudan is between 0-20%. Methodology: this is a descriptive cross sectional study, we screened all the school aged children from the two villages of Elkeriab and Tayba Elkababish in the East Nile locality, Khartoum state; for S.haematobium, by examining the urine, using wet preparation and filtration technique. Results: 1205 school children were screened for S.haematobium, 105(8.7%) tested positive for Schistosoma, the infection rate was more in Tayba Elkabish compared to Elkeriab (p value=0.01) and in male more than females (p value =0.01). Conclusion: S.haematobium infection is still a common infection in school ages children, in rural and irrigated schemes, mainly affected males. Schistosoma control programs have reduced the prevalence of S.haematobium infection but still there is a long road towards eradication of Schistosoma.
Biliary botryoid rhabdomyosarcoma in a pediatric patient
Authors: Temtem Tsega
Published: February 2023

Biliary rhabdomyosarcomas are rare, making up about 1% of all liver malignancies. These tumors are often an embryonal subtype and generally large, measuring multiple centimeters. We present an 11-year-old female with a history of intermittent painless jaundice and imaging suspicious for a choledochal cyst. Endoscopy identified a lesion protruding from her ampulla, and pathology diagnostic of a botryoid variant of embryonal rhabdomyosarcoma. She improved with chemotherapy and radiation. Botryoid biliary rhabdomyosarcomas typically have rapid growth with early presentation of jaundice around 3.5years old; however, this case was reported in an older child with a protracted history of intermittent jaundice.
Childhood encephalitis: what's new?
Authors: Ferreira Da Costa Coelho Alexsandra , Ferreira Chaves José , De Sousa Gomes Da Costa Mariana , Patrícia Dos Passos Lima Santos Michelly
Published: February 2023

Encephalitis is a severe form of a neurological disease caused by an inflammation of the brain parenchyma associated with evidences of neurologic disfunction, which courses with non-specific CNS symptoms. The frequency of this condition is higher in children, presenting in this age group a great potential of severity, in addition to higher risks of morbidity and mortality the younger the affected child. The etiology can be infectious or autoimmune; in about half of the cases of acute encephalitis during childhood, however, a definitive cause will not be found. Objective: To accomplish an epidemiology, diagnostic methods and treatment review about childhood encephalitis. Methods: Studies were made in June to October 2017, and was constituted by the search of the key-words “encephalitis”, “childhood”, “autoimmune encephalitis”, “viral encephalitis”, “meningoencephalitis”, “etiology” and “epidemiology” from articles published in English and Portuguese in the years of 2004 until 2017, thus being selected 23articles, accordingly to the relevance of the information presented. Theory: Encephalitis is a potentially lethal neurologic syndrome, that affects children around the world, and can be caused by infectious processes, autoimmune conditions, or can still be from unidentified etiology in most of the cases. The diagnoses can be difficult for the rapid progression, the nonspecific symptoms and vast possibilities of etiologic agents. It is a condition that presents itself with elevated potential of death and permanent sequelae, mainly in younger children. Conclusion: Encephalitis is a serious disease, which can bring grand repercussions in children’s health, such as development retardation, behavioral abnormalities and direct neurologic damage. Considering this issues, it is indispensable the correct diagnostic e quick therapeutic approach from the child suspected to be in this condition.
Peritoneal dialysis after pediatric cardiac surgery: benefits and risks
Authors: Saadé Samer , Hanna Najib , Mourani Chebl
Published: February 2023

Introduction: Neonates and infants having surgical repair for congenital heart disease are at risk of developing acute kidney injury (AKI). Our objectives were to determine surgeries most associated with AKI, to compare effect of peritoneal dialysis (PD) and conventional treatment, and to study the risk factors associated with PD mortality. Materials and methods: Records of Children who underwent cardiac surgery from November 2016 until December 2017 were reviewed. Clinical and biological effects of PD and conventional treatment were compared. In PD group, subgroups of survivors and non-survivors were compared to study risk factors for mortality associated with PD. We compared mortality between early and late PD (more than 24 hours after surgery). Results: 134 children were operated during the study period. 27 (20%) developed AKI and 9 of those (33%) received PD. Arterial switch was most associated with AKI (71.4%). PD had better effect in decreasing creatinine and blood urea nitrogen (BUN) levels after 48 hours treatment than conventional treatment (creatinine: 28.8±14.5 vs 7.5±12.1micromol/L, p=0.003) (BUN: 3.08±2.1 vs 0.91±1.5mmol/L, p=0.017). In PD group, survivors (n=5) had higher mean arterial pressure in the 6 hours prior to PD that non-survivors (n=4) (55.3±9.6 vs 40.0±3.6 mmHg, p=0.019). Survivors had also higher pH 24 hours after PD (7.37±0.03 vs 7.31±0.02, p=0.014), better creatinine variation (-3.6±5.8 vs 29.0±13.0micromol/L, p=0.02), and better diuresis improvement (4.4±3.2 vs 0.23±1.1ml/kg/h, p=0.039). There was no mortality difference between early and late PD. There were no major complications with PD. Conclusion: PD is safe for AKI after heart surgery. It has better outcome on BUN and creatinine levels. PD mortality is higher with low cardiac output, persistence of acidosis and absence of creatinine or diuresis improvement.
Is it now time to screen your baby for spinomuscular muscular atrophy?
Authors: Lakra Mahaveer Singh , Lakhkar Bhavana , Ahlawat Kuldeep Singh
Published: February 2023

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Treatment strategies in management of chronic kidney disease from perspective of biological regenerative medicine
Authors: Klokol Dmytro , Nallenthiran Lingeswran , Nalapko Yuriy , Chernykh Volodymyr , Yefimov Simon , Yemeliyanova, Margarita , Chuaiwongyat Aunyawut
Published: February 2023

Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function that happens over time and from the point of view of modern conventional medicine is considered to be an incurable and irreversible disease. The main risk factors attributing to CKR are diabetes mellitus, hypertension, glomerulonephritis, renal artery stenosis and family history of kidney disease. Affecting approximately 1 in 10 people of a Global population CKD imposes a significant threat to individuals’ lives and carries a major financial burden to patients and healthcare systems. CKD is the cause of at least 1 million deaths per year globally and consume nearly 6% of all medical expenses. In this article we discuss possibilities of disease control and reversal from the perspective of Biological Regenerative Medicine.
Disfiguring lupus panniculitis: case report and review of the literature
Authors: Elboukhari Khadija , Baybay Hanane , Dassouly Rime , Elloudi Sara , Mernissi Fatima Zahra
Published: February 2023

Lupus panniculitis also called lupus profound is a rare variant of chronic cutaneous lupus. This entity share histological characteristics with subcutaneous T cell lymphoma, which require a lot of times, a clinical biological and histological correlation. This entity is difficult to treat and oral corticoids seem to be the mainstay therapy. We report a case of a woman who presented systemic lupus erythematous with a cutaneous involvement as panniculitis and a good response to antimalarials.
Testing the Microsoft kinect skeletal tracking accuracy under varying external factors
Authors: Eduardo Taboada Diaz Joyce , Boss Ronald , Kyberd Peter , Biden Ed Norman , Diaz Novo Carlos , Hernández Ricardo Maylin
Published: February 2023

Focusing on its possible use in motion analysis, the accuracy of the Microsoft Kinect was investigated under various external factors including relative position, external IR light, computational power and large nearby surfaces. Two different experiments were performed that either focused on a general situation in an open room or when seated at a table. Results indicated that a large number of factors signiﬁcantly affect the measurement error, but with only minor effect sizes, where the relative position and orientation have shown to be most inﬂuential. Additionally, body movement and increased depth contrast (i.e. isolation from surrounding objects) are believed to increase the accuracy of the skeletal tracking process.
Human Visual System involves macroscopic scaleinvariants and microscopic quantum mechanics single-photon sensitivity
Authors: Szu Harold
Published: February 2023

“A half Century has gone by; the general public seems to be lacking a simple Readers’ Digest knowledge about human visual system (HVS). In order to ward off wolf eyesight emitting few photons in a dark cavern, we have evolved to separate the energy from the information, as well as adopt the negation of the converse detection logic. To achieve the sensitivity, HVS uses the dark (no light yet) current, discovered by NIH Hagins, to inhibit 100 rods' bundled together by Ganglion integrator by using its own energy firing. We have applied the dark current to inhibit firing, until a detection of a single photon of wolf eyesight by any of the rod bundle. In this short communication, we shall give 2 theorems: macroscopic scale invariants and microscopic quantum mechanics. Now we know why we can see red color while the other animal cannot and why we can detect a single photon while the other cannot. Given the basic deep learning algorithm and possible experiments to verify Quantum Mechanics Uncertainty Principle for HVS single photon detection capability according to the Gold Standard: Double Blind, Negative Control and Sufficient Statistics.”
How to capture emotional & religious sensitivity for Android Robotics
Authors: Szu Harold
Published: February 2023

According to UN population statistics, the global childbirth rate has reached less than one per family. Who is going to take care of home-alone-sensors (HAS) in the coming decades? One answer is humanoid android robots! Then, the question remains whether the humanoids can perceive HAS (a) emotions and sensitive to its (b) religious belief. Our paper describes such a possibility! (a) Emotions by Deep Learning; (b) Religious Belief by Pastor Niebuhr Reinhold Serenity Prayer with the triplet: Courage, Serenity & Wisdom happened to match: "If ,The ,or Else" AI logic, as developed by Stanford, John McCarthy,& Bell Lab, Claude Shannon.
Adverse effects, studied on ants, of six products largely used by humans; a mini review
Authors: Claire Cammaerts Marie
Published: February 2023

Working on ants as models, we examined the side effects of six largely used products, separately published our findings, and here summarize them for the readers’ convenience. The herbicides, the active substance of which is pelargonic acid, must be used only for not cultivated area since they impact the live of the soil fauna. Imodium, the active substance of which is Loperamide, used to stop diarrhea, should be used during short time periods, monitoring the patients as for their food consumption, locomotion, social relationships, cognition and dependence on the drug use. Only small amount of the myorelaxant Epsipram, the active substance of which is Tetrazepam, should be used, monitoring the patients as for their activity, locomotion, social relationships, stress, cognition, memory and dependence on the drug consumption. The antiemetic Motilium, the active substance of which is Domperidone, should be used after having made an adequate clinical examination of the patients, take then care of them monitoring them as for their health since side effects may occur. The dietary supplement Cognizing, the active substance of which is citicoline, should not be used, being inefficient and causing stress, agitation, nervousness and strong dependence on its consumption. The dietary supplement PQQ is efficient and has no adverse effect; it could be used, but at low doses, since, being novel, some not yet observed side effects may occur.
Production of propolis and geopropolis by stingless bees
Authors: L Pereira Leonardo Regnier , F Salatino Maria Luiza , Salatino Antonio
Published: February 2023

Propolis is a resinous product produced by honey bees (Apis mellifera) with plant exudates or buds, to which they aggregate beeswax. Most stingless bees (meliponines) produce propolis in ways similar to honey bees. Several meliponines include soil in their propolis, with the effect that the final mass and volume of the product is increased. For this reason, meliponine propolis is in general called geopropolis. In the present work propolis of two meliponines native in Brazil, Melipona marginata and Scaptotrigona xanthotricha, were analyzed for determination of the contents of moisture, ashes, wax, total phenols and sequestering activity. The content of ashes of propolis of M. marginata was very high (73.66%), indicating that the product, in fact, contains soil. On the contrary, the content of ashes of S. xanthotricha (1.99%) is comparable with the ash content of propolis of honey bees. Thus, the propolis of S. xanthotricha does not contain soil, and thus, in this case, the designation geopropolis is not appropriate. The contents of the wax of propolis were 1.44% for M. marginata and 28.82% for Scaptotrigona. These results suggest opposed strategies adopted by meliponines, with the consequence of enlarging propolis volume and mass. The strategies are an aggregation of either soil (M. marginata) or wax (S. xanthotricha). The contents of total phenols for both species were low, below the minimum admitted by Brazilian official rules. Coherent with the content of total phenols, the sequestering activity also was lower for propolis of both species.
Electron structure and thermodynamics of solid solutions in Ni–H system
Authors: VG Gavriljuk
Published: February 2023

The widespread concept of nickel hydride in the Ni–H system is discussed based on the first–principle atomic calculations and experimental X–ray diffraction data. The total cohesion energy in Ni–H solid solution has been determined using the density functional theory and program package Wien2k. Its dependence on hydrogen concentration is shown to be linear, which suggests the absence of any energy barrier for precipitation reaction. Moreover, the second derivative of the calculated solution enthalpy is negative within the hydrogen–to–nickel ratios, H/Ni, of 0.03 to 0.75, which is a sign of spinodal decomposition. These hydrogen concentrations are consistent with the measurements of X–ray diffraction, of which results are traditionally interpreted in terms of Ni hydride. The density of electron states has been calculated, and its non–monotonous concentration dependence correlates with that of solution enthalpy, which is also expected for spinodal decomposition. The obtained results are interpreted as miscibility gap in the Ni–H system with spinodal decomposition having the electron origin. In addition, using mechanical spectroscopy, the strain dependent internal friction has been observed in the hydrogen–charged nickel with H/Ni ratio of about 0.7. This effect is controlled by irreversible plastic deformation, which is typical for solid solutions, not for brittle chemical compounds. Finally, the “hydrides” in a number of metals are discussed in terms of two Gibb’s types of precipitation reactions. Keywords: nickel, hydrogen, ab initio calculations, spinodal decomposition, hydride
Accidents & consequences
Authors: Vandali Vijayaraddi
Published: February 2023

Each year approximately 1.35 Million accidents happen in our country with minor to major injury, death, economic status affects, and family support disturbs. As per statistical information there is more than 3 lakhs death due to accidents in India each year. The National Highways accounted for 29.6 per cent of total road accidents and 34.5 per cent of total number of persons killed. 1,46,133 people had died in 5,01,423 accidents in 2016. The major cause for the accidents is unsafe drive, drink and drive, unsafe roads, traffic rules violation etc. the prevention will be regarding better road construction, strict laws and awareness regarding traffic rules among the public.
Nursery activity and quality, chemistry between doctors and nurses
Authors: Lu Da-Yong , Chen Yu-Zheng , Lu Da-Feng
Published: February 2023

A great proportion of healthcare efforts need high-quality medication and nursery. For high-quality nursery, education plays key roles. Currently, nurse education is divided into two major domains—specific technical mastering and wide-range of medical knowledge. It is suitable to different patterns of educational systems, such as nurse recruitments, personal goals and career design. This editorial addresses this part of medical challenges of nursery education—including education from medical schools and special education and performances in hospitals and healthcare centers.
Follow-up of pressure injury associated with the use of Tala and use of varied techniques in the treatment of the wound
Authors: de Souza Milani Barbosa Caren Leticia , Adriana Fank , Jacob Pimenta Graziele
Published: February 2023

Wound is any damage caused by interrupting the continuity of a body tissue, to a greater or lesser extent, caused by trauma or triggered by a clinical condition. Objective of this research is the nursing conduct used in the treatment of pressure injuries that are applied during the evaluation and evolution of the case of patients admitted to the Regional Hospital of Vilhena - RO. Method: this is a descriptive case study, with qualitative approach, the research will be carried out at the Regional Hospital of Vilhena in 2018, it will be a project based on research ''Pressure injury associated with splint use. case study of a patient seen in an emergency care unit: evaluation, diagnosis and nursing interventions''. Results and discussions: The use of various techniques for the assessment and evolution of the wound has been shown to be very effective in terms of healing time, less exposure to the patient and less risk of infection. Conclusion: Although this study is limited by the fact that it is a unique case, it is relevant for health professionals, mainly nurses, for managers of institutions and for the practice of caring for people with LPP because it seeks to analyze the effectiveness of therapies implemented in injuries, and should be replicated in other institutions and in other patient profiles.
A study to assess the healthy lifestyle practices among south indian population
Authors: SK Mohanasundari , A Padmaja , Jeet Rimple , Joseph Joyce , VA Raghu
Published: February 2023

Introduction: Unhealthy diet, smoking, alcohol, drug abuse, poor sleep, abuse of technology, stress and so on, are the presentations of unhealthy lifestyle that they are used as dominant form of lifestyle. Lifestyle has a significant influence on physical and mental health of human being. Hence the relationship of lifestyle and health should be highly considered. Methodology: Under quantitative approach a descriptive cross-sectional survey was conducted among 668 south Indian population to assess the level of healthy lifestyle practices. They were accessed through direct contact or electronic mode (mobile survey app). The tool has two section; demographic variables and practice check list to measure healthy lifestyle practices. Data collection method was self-report technique, a structured questioner was distributed to samples through direct contact and through mobile app (what app, email, twitter, and Facebook).The obtained sample was coded and analysed in SPSS version. Result: The samples had average healthy lifestyle practices as indicated by mean score and standard deviation (6.95±1.879). The demographic variables such sex, age, education and religion had significant association with level of lifestyle practices, whereas geographic region, place of living, and occupation had no significant association at P <0.05. Conclusion: From the above findings it was concluded that the south Indian population had average lifestyle practices and they should improve it from current level to healthy lifestyle practice.
Multipurpose technology for simultaneous preparation of primary and secondary tillage of the soil (second phase: construction and evaluation of the prototype)
Authors: Reynolds Chávez Marco Antonio , Burela Ángel Capetillo , López López Juan Antonio , Zetina Lezama Rigoberto , Cadena Zapata Martín , Quintos Jaime Rangel
Published: February 2023

In Mexico, the continuous increase in the prices of fossil fuels and agricultural fertilizers has led to a reduction in the area planted with crops, specifically basic grains. This situation has caused substantial ecological and economic losses and a national deficit in the production of basic grains, which has aggravated the economic and social situation of agricultural producers. Faced with these production growth limitations, it is important to generate new practices and innovations that contribute to reducing these factors. In soil preparation, which is considered one of the most costly activities in food production, there is an enormous technological lag. At present, the discs plow is still by far the most widely used implement for primary soil preparation in food production, causing high rates of soil loss due to erosion, hard layers, minimal use of moisture and, consequently, low productivity. Likewise, it requires high power requirements, excessive operation times and high fuel consumption. The purpose of this research was the construction and evaluation of a prototype for simultaneous preparation of primary and secondary tillage of the soil for crop establishment to reduce operation times and fuel consumption, without detriment to the quality of work and increase yields. The results show a mechanical equipment integrated by three sections (chisel plow + harrow + lump breaker), which are combined for the simultaneous preparation of primary and secondary tillage of the soil. This technology is responsible for performing in a single step, the soil conditioning for crop production, significantly surpassing the conventional system.