bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence assessment of shut-in duration and well startup sequence in different geological and field conditions
Authors: Grezin A. V. , Sagitov D. K.
Published: May 2024

During 2019-2021, about half of well stock at West Siberian oil fields were shut down for a long period (up to one and a half year) due to oil production restrictions under the agreement between Russia and OPEC (Organization of the Petroleum Exporting Countries). There have never been such large-scale and prolonged shutdowns before. After starting from a long-term shutdown, the flow rate of some wells increased, while others decreased.

The main aim of research is to assess the geological and technological factors affecting the results of starting wells after a long shutdown. Statistical methods were used, including multivariate regression analysis, assessing the influence of parameters on each other using trend lines on cross-plots, as well as constructing and comparing maps of geological and technological parameters.

As a result, the influence of the duration of downtime, the simultaneity of shutdown of production and injection wells and compensation of production by injection was determined. That will help to reduce losses in case of repeated production restrictions by selecting optimal candidates for shutdown.
THE REMUNERATION-PERFORMANCE RELATIONSHIP IN CORPORATE GOVERNANCE: EVIDENCE FROM BOARD MEMBERS’ REMUNERATION AND FIRM PERFORMANCE
Authors: Özer Gökhan , Aktaş Nagihan , Merter Abdullah Kürşat
Published: May 2024

The board of directors is an important corporate governance mechanism as it is responsible for the operation of a firm and protects the value of the investment made by investors in the firm. Therefore, board members should be supplied with an appropriate incentive to properly discharge their duties. One of the most important incentive mechanisms is remuneration. This study aims to reveal the effect of board members’ remuneration on the firm performance. Regression analysis was performed to test the hypotheses. 210 firm-year observations obtained from 76 non-financial firms traded in the BIST 100 between the 2018-2020 period were used. The indicators of firm performance return on assets, return on equity, and earnings per share. As a consequence of the study, the relationship between board members' remuneration and firm performance was found to be positive and statistically significant. These results show that the board members' remuneration is a strong incentive used to increase the firm performance and that a suitable remuneration policy should be established for directors.
BASKI MAKİNESİ SEÇİMİNDE BULANIK AHP VE BULANIK EDAS UYGULAMASI
Authors: Sancar Semih , Gül Sait
Published: May 2024

İşletmeler için makine parkı yatırımı, önemli kaynak gerektiren ve sonrasında tüm üretim faaliyetlerini de etkileyen önemli bir karar sürecidir. Uygun makine kullanımı üretim süreçlerini iyileştirir, verimliliği ve güvenilirliği arttırır, üretimde esneklik ve etkinlik sağlar. Tecrübe ve bilgi gerektiren bu süreç birçok kriter içermekte ve birden fazla birim bu süreç içerisinde yer almaktadır. Baskı makinesi seçim problemini, bulanık çok kriterli karar verme yöntemleri ile çözmeyi amaçlayan bu araştırmada; bir gazete baskı tesisinde yapılacak makine parkı yatırımı için en uygun baskı makinesi belirlenmeye çalışılmıştır. Kriterlerin önem ağırlıklarının belirlenmesinde Bulanık AHP, alternatiflerin kriterler bakımından değerlendirilmesinde ise Bulanık EDAS yöntemleri kullanılmıştır. Çalışmada, uzman görüşleri ve literatür taraması sonucu değerlendirmeye alınan kriterler şöyledir: maliyet, verimlilik, esneklik. Makine alternatifleri olarak ise, süreç için uygun olduğu ve satın alımının yapılabileceği düşünülen dört farklı baskı makinesi seçilmiştir. Karar verici grup; matbaa müdürü, iş geliştirme müdürü, teknik müdür ile elektrik ve mekanik bakım mühendislerinden oluşmaktadır. Dilsel ifadelerdeki değişikliklerin analiz sonucuna etkisini test etmek amacıyla yapılan duyarlılık analiz sonuçları araştırmanın geçerlilik düzeyinin iyi olduğunu göstermektedir.
THE MEDIATING ROLE OF CULTURAL INTELLIGENCE IN THE RELATIONSHIP BETWEEN PERSONALITY AND CROSS CULTURAL ADAPTABILITY: A RESEARCH ON GRADUATE STUDENTS
Authors: Mutlu Ceyhan , Arıkboğa Fatma Şebnem
Published: May 2024

Individuals' desire to live in different nations to improve their living standards grows as globalization accelerates and countries' environmental conditions change. Even though people have a strong desire to do so, it is extremely difficult to adapt to a new culture. There are numerous factors that influence people's cross-cultural adaptability. The concept of cultural intelligence, which plays an important role in helping individuals understand individuals from different cultures and behave appropriately in that culture, is the most important of these factors. Cultural intelligence analysis can help individuals overcome or avoid these challenges. Individuals' personalities, in addition to cultural intelligence, are considered as another factor that has a significant impact on the results. The analysis of personality structures can reveal whether or not they can adapt to different cultures. The purpose of this study is to investigate the concepts of cross-cultural adaptability, cultural intelligence, and personality in the context of Business Administration graduate students' intentions to live abroad and to determine the extent to which these three concepts are related.
FOREIGN DIRECT INVESTMENT, TRADE GLOBALISATION, RENEWABLE ENERGY, AND INDUSTRIALISATION IN TÜRKİYE
Authors: Nas Şahin
Published: May 2024

Recently, interest in industrialisation has increased again, and re-industrialisation policies have begun to be discussed. Because empirical and theoretical evidence indicates that industrialisation plays a significant role in economic growth and development. Nevertheless, studies analysing the factors affecting industrialisation are limited. In consequence, the main purpose of this paper is to analyse the dynamics of industrialisation in Türkiye over the period 1990-2020. For this purpose, the effects of foreign direct investments (FDI), trade globalisation, and renewable energy, which are thought to affect industrialisation significantly, are investigated. The ARDL bounds test, and the Toda-Yamamoto (1995) causality test are employed in this respect. The findings prove that FDI, trade globalisation, and renewable energy consumption positively impact industrialisation in the long-run. At the same time, Toda-Yamamoto's (1995) causality test results indicate a unidirectional causality from FDI to industrialisation, bidirectional causality between renewable energy and industrialisation and no causality between trade globalisation and industrialisation. In this regard, for sustainable industrialisation, effective policies are necessary for FDI, trade globalisation, and renewable energy. In addition, FDI inflows should be directed to specific sectors.
Pemilihan Sistem Air Limbah-Lumpur Tinja Komunal Menggunakan Analisis Kluster Hierarki
Authors: Hastuti Elis , Benny Joy  , Unang Supratman
Published: May 2024

Pengelolaan lumpur tinja dari instalasi pengolahan air limbah (IPAL) desentralisasi merupakan tantangan di kawasan permukiman yang memiliki keterbatasan akses ke sarana pengolahan lumpur tinja terpusat. Pada tulisan ini, dikaji pemilihan dan strategi pengembangan sistem IPAL komunal dan pengolahan lumpur tinja terintegrasi (SIPAL-LT). Faktor-faktor dominan keberlanjutan pengembangan IPAL menentukan pemilihan SIPAL-LT, yaitu faktor sistem pengolahan, pengelolaan, lingkungan, dan karakteristik masyarakat.  Pengembangan IPAL terintegrasi di lokasi studi ditentukan berdasarkan profil keberlanjutan, pilihan teknologi, dan profil pengembangan SIPAL-LT. Pemilihan dan penentuan prioritas pengembangan SIPAL-LT dianalisis dengan metode kluster hierarki, sedangkan strategi pengembangannya menggunakan analisis kuadran. Pilihan SIPAL-LT dapat dikembangkan pada kluster yang  memiliki karakteristik, yaitu air limbah domestik berkategori pencemar rendah-sedang, pengguna IPAL komunal eksisting lebih dari 60% kapasitas, lumpur tinja berkategori pencemar rendah, tingkat pemeliharaan IPAL komunal berkategori rendah-sedang, indeks efektifitas IPAL komunal lebih dari 60%, dan tingkat partisipasi masyarakat berkategori sedang-tinggi.  Pilihan SIPAL-LT terbaik berada di lokasi studi yang telah memanfaatkan IPAL komunal teknologi biofilter atau digester anaerobik, sedangkan pengolahan lumpur tinja direncanakan menggunakan sistem constructed wetland atau kombinasi sistem sludge drying bed dan sistem co-composting.
СТАН ТА ЦИФРОВІ ВЕКТОРИ РОЗВИТКУ РИНКУ СТРАХУВАННЯ УКРАЇНИ
Authors: МАЗУР Дмитро , МАЗУР Олександр , MAZUR Galina , КОВБІЙ Антоніна
Published: May 2024

The article examines the current state and digital vectors of the development of the insurance market of Ukraine and identifies promising directions for the digitalization of insurance.
The essence of the insurance category is revealed. It is noted that the insurance market in Ukraine lags far behind developed countries. An analysis of the dynamics of the number of participants in the insurance market, the amount of assets of insurance companies, the structure of the insurance portfolio by types of insurance was carried out, and the main trends of the insurance market in Ukraine were revealed. The keys to the stable development of insurance activity in Ukraine have been defined as: quick response to new conditions and customer requests; the ability to adapt, accumulate positive experience, analyze and correct negative moments; develop harmoniously, find a balance between the accumulation of new knowledge and their practical application.
Factors influencing and functioning of the domestic insurance market are determined.
The features of modern trends in digital insurance tools, as an important mechanism for the growth of the insurance market, are revealed.
It was found InsurTech  that modern technologies are important for insurance companies. These  InsurTech nclude artificial intelligence technologies, new inventions in the field of cyber security, big data analysis («bigdata), blockchain technologies, the Internet of Things (LoT ) and smartphone applications.
ПАРАДИГМА ЦИФРОВОЇ ТРАНСФОРМАЦІЇ БІЗНЕС-ПРОЦЕСІВ ПІДПРИЄМСТВА
Authors: ФЕРНАНДЕС Реа Крістіан Еліас
Published: May 2024

The article is devoted to the actual problem of substantiation of scientific and methodological provisions and development of practical recommendations on the paradigm of digital transformation of business processes of enterprises. It is determined that for successful operation in the market, enterprises must develop a business model to create value for customers and make a profit by the company. Five main areas covered by digital transformation are revealed: business model transformation, automation and optimization of business processes, innovation in digital products and services, empowerment and employee engagement, and customer interaction. The definition of "digital transformation" is given as the integration of digital technologies into all business areas, which radically changes the principles of enterprise operation and providing value to customers. The advantages that enterprises that make the transition to the digital transformation paradigm receive are revealed: a better understanding of market trends; expanding markets and sales channels; ensuring compliance with customer expectations and meeting their needs; increasing customer loyalty; expanding opportunities to reduce costs and increase profitability. The stages of forming a digital transformation strategy are substantiated, which consist in the following: defining the mission and strategic vision; auditing the existing business strategy; reviewing business processes to add value to the product using digital technologies; defining your own priority projects; developing a system of necessary competencies; outsourcing of functions to partners or external organizations; identification of key indicators of the organization's development and measures to implement the strategy; optimization of the management process and formation of Digital Culture; selection of the most effective digital technology. Companies that have successfully applied digital technologies to transform their business in various fields of activity are represented: Walmart in retail, Mayo Clinic – medical services, investment bank Goldman Sach, travel and hotel company Airbnb, car manufacturer Toyota.
ОСОБЛИВОСТІ ОЦІНЮВАННЯ ЕФЕКТИВНОСТІ ДІЯЛЬНОСТІ ТА РОЗВИТКУ МЕДИЧНИХ ОРГАНІЗАЦІЙ
Authors: ТЮРІНА Ніла , АНТОНЮК Василь
Published: May 2024

In the study, the concepts of "effect", "efficiency" and "effectiveness" are defined and distinguished, possible directions and components of achieving results are defined. The essential characteristics of the concept of efficiency in the field of health care have been clarified. It is substantiated that the main priority directions of the analysis of the activity of a medical organization are the assessment of the level of achievement of medical, social and economic efficiency, the detailed content of these concepts. Indicators and criteria for the effectiveness of medical institutions, basic principles of economic efficiency evaluation, and their content have been formed. The main features of evaluating the effectiveness and development of the activity of a medical organization are highlighted. The need to increase the efficiency of management of health care facilities under modern conditions has been updated. A structural scheme for improving the efficiency and development management mechanisms of the medical organization was developed. The priority directions for improving the efficiency of health care facility management have been determined. It was established that the strategic activity of a medical institution can be presented in the form of four main perspectives: finances, personnel, patients, and internal processes. A structural diagram of the strategic activity of the medical institution within the framework of the system of balanced indicators has been developed.
Daur Ulang Minyak Jelantah Pada Kelompok Pemuda Remaja GPDI Jemaat Ekklesia Padang Bulan, Jayapura
Authors: Menufandu Herlina , Lunga Nelly
Published: May 2024

Cooking oil is not only necessary for frying but also as for flavor additive to the foods. Repeated use of cooking oil (Used Cooking Oil/ UCO) can affects its quality and caused a risk for human health. In addition, UCO could potentially be a contaminant to the environment as well. Therefore, our activity aimed to use the UCO as materials for candle making. We targeted people at the youth age as targeted community and introduce the technology to reuse UCO for candle making. Sharing information and practice was conducted to increase the enthusiasm of participants. At the end of the program, participants were able to make candles and also put some aroma therapy essence into the candle made from UCO.Â Keyword: aroma therapy; used cooking oil (UCO); candle.Â
Pembuatan Aneka Bakery Berbasis Umbi-Umbian Hasil Panen Jemaat GPdI Blessing Distrik Heram, Kota Jayapura
Authors: Menufandu Herlina , Lunga Nelly , Suyono Ign. Joko
Published: May 2024

Tubers are one of the local foods besides rice and corn which have the potential as alternative food. Processing of tubers in Papua is generally still carried out simply and on small industry likes home industry. Various tuber are usually consumed by local people by boiled, fried, baked, and steamed. Many modern food are made from tuber flour to increase consumer interest. Generally, local people tuber crops are sold without going through modern processing. Low technological innovation and creation of local food causes the low consumer interest to consume various local food products. This activity was carried out with the aim of being GPdI, Blessing congregation, to increase the congregation insight so they interest to increase local food product by increase the nutritional value and selling value of the congregationâ€™s crops in modern packaging. Theoretical and practical methods are carried out with the intention of providing an explanation regarding the processing of tubers in to modern products. The practice was carried out so that the participants could directly make various bakeries made from tubers. During the activity, start to finish, participants were enthusiastic andÂ  were able to produce various bakery produks such as bread, brudel, and brownis cake.Â Keyword: Tubers; Bakery; GPdI Blessing; Heram
Pelatihan Pemanfaatan Bahan Alam di Lingkungan Sekolah Untuk Praktikum Biologi di Tigkat SMP/SMA
Authors: Purnamasari Vita , Sujarta Puguh , Suyono Ignatius Joko , Farmawaty Farmawaty , Yuliana Yuliana
Published: May 2024

Practical activities are part of teaching which aims to give students the opportunity to test and implement in real situations what is obtained in theory. The use of natural materials in the school environment, apart from having cheap capital, has a big advantage, namely getting to know the school environment closely. The aim of this service activity is to provide provisions for biology teachers in SMP/SMA. Community Service will be held on July 15 2023. Participants will be SMP/SMA of the biology teachers in the MGMP area of Keerom Regency. The activity method uses lecture, discussion and simulation methods in practice. The results of the activity showed that the activity participants were very enthusiastic and able to utilize natural materials in the school environment in biology practicum activities.
Poppies and Women Under the Linden Tree in a Slovak Village
Authors: Chovanec Zuzana
Published: May 2024

In her 1993 book, ‘What This Awl Means’, Jane Spector examined the relationship between gender, objects, environment and archaeology through a female personal narrative. While such historical storytelling has been viewed as unconventional, it is effective as it paints a vibrant picture communicating context, significance and insight into what might otherwise be viewed in traditional archaeological description as a simple, utilitarian tool. However, to do this effectively, sufficient cultural competence and symbolic understanding must be woven with archaeological research, anthropological interpretation and understanding of the cultural and historical context through the lens of storytelling. This paper explores this approach by presenting the complex symbolic and agroeconomic relationships maintained with the opium poppy (Papaver somniferum L.) and the linden tree (Tilia sp.) by ancient peoples in Central Europe. The story draws on a body of archaeological, botanical and chemical research, Slovak cultural and linguistic background, as well as ancestral oral history.
Non-Muscle Invasive Bladder Cancer: Many More Patients Die With It Than Of It
Authors: McGonagle Kathryn , Dematt Ellen J. , Mi Zhibao , Biswas Kousick , Schroeck Florian R.
Published: May 2024

BACKGROUND:

The National Cancer Institute SEER Program regularly publishes bladder-cancer specific survival statistics. However, this data is for all bladder cancers, and information for non-muscle invasive bladder cancer (NMIBC) is difficult to obtain.

OBJECTIVE:

To quantify 5-year overall and bladder cancer-specific survival in a cohort of Department of Veterans Affairs (VA) patients diagnosed with NMIBC.

METHODS:

We identified VA patients diagnosed with NMIBC who underwent a transurethral resection from 2003-2013. The patient demographics and Charlson Comorbidity Index were categorized. We acquired the patients’ date of death from the Veterans Health Administration’s Death Ascertainment File and their cause of death from the Mortality Data Repository. We calculated Kaplan Meier estimates of survival.

RESULTS:

A total of 27,008 patients were included; median age was 69 and almost all were male (99%). The median comorbidity score was 4. The most prevalent comorbidity indicators included Chronic Pulmonary Disease (48%), cancer other than Bladder (41%), and diabetes (40%). This cohort was found to have a 5-year overall survival of 68% (99% CI 67% –69%) and a 5-year bladder cancer-specific survival of 93% (99% CI 92% –94%).

CONCLUSIONS:

The 5-year bladder cancer-specific survival in patients diagnosed with non-muscle invasive bladder cancer is substantially higher than the 5-year overall survival. This difference may be related to the severity and number of comorbidities that patients in this population must manage. This warrants further research into the necessity of currently recommended high-intensity cancer surveillance for individuals with NMIBC.
Activation of Pink1/Parkin-mediated mitochondrial autophagy alleviates exertional heat stroke-induced acute lung injury in rats
Authors: Wang Jiaxing , Sun Zhengzhong , Jiang Liya , Xuan Lyv , Ma Yunya , Wang Jiao , Gu Yan , Zhang Yuxiang
Published: May 2024

OBJECTIVE: To investigate the role of Pink1/Parkin-mediated mitochondrial autophagy in exertional heat stroke-induced acute lung injury in rats. METHODS: Sixty SD rats were divided into four groups: normal group (CON group), normal Parkin overexpression group (CON + Parkin group), exertional heat stroke group (EHS group), and exertional heat stroke Parkin overexpression group (EHS + Parkin group). Adeno-associated virus carrying the Parkin gene was intravenously injected into the rats to overexpress Parkin in the lung tissue. An exertional heat stroke rat model was established, and survival curves were plotted. Lung micro-CT was performed, and lung coefficient and pulmonary microvascular permeability were measured. RESULTS: Compared with the EHS group, the survival rate of rats in the EHS + Parkin overexpression group was significantly increased, lung coefficient and pulmonary microvascular permeability were reduced, and pathological changes such as exudation and consolidation were significantly reduced. The levels of inflammatory factors IL-6, IL-1β, TNF- α, and ROS were significantly decreased; the degree of mitochondrial swelling in type II alveolar epithelial cells was reduced, and no vacuolization was observed. Lung tissue apoptosis was reduced, and the colocalization fluorescence of Pink1 and Parkin, as well as LC3 and Tom20, were increased. The expression of Parkin and LC3-II/LC3-I ratio in lung tissue were both increased, while the expression of P62, Pink1, MFN2, and PTEN-L was decreased. CONCLUSION: Impairment of Pink1/Parkin-mediated mitochondrial autophagy function is one of the mechanisms of exertional heat stroke-induced acute lung injury in rats. Activation of the Pink1/Parkin pathway can alleviate acute lung injury caused by exertional heat stroke.
End of Life Events and Causes of Death in Danish Long-Lived Siblings: Reduced Dementia Risk Compared to Sporadic Long-Livers
Authors: Galvin Angéline , Pedersen Jacob Krabbe , Arbeev Konstantin G. , Feitosa Mary F. , Ukraintseva Svetlana , Yao Shanshan , Newman Anne B. , Christensen Kaare
Published: May 2024

Background:

Better physical robustness and resilience of long-lived siblings compared to sporadic long-livers has been demonstrated in several studies. However, it is unknown whether long-lived siblings also end their lives better.

Objective:

To investigate end-of-life (EoL) events (dementia diagnosis, medication, hospitalizations in the last 5 years of life), causes of death, and location of death in long-lived siblings compared to matched sporadic long-livers from the Danish population.

Methods:

Long-lived siblings were identified through three nationwide Danish studies in which the inclusion criteria varied, but 99.5% of the families had at least two siblings surviving to age 90 + . Those who died between 2006 and 2018 were included, and randomly matched with sex, year-of-birth and age-at-death controls (i.e., sporadic long-lived controls) from the Danish population.

Results:

A total of 5,262 long-lived individuals were included (1,754 long-lived siblings, 3,508 controls; 63% women; median age at death 96.1). Long-lived siblings had a significantly lower risk of being diagnosed with dementia in the last years of life ( p = 0.027). There was no significant difference regarding the number of prescribed drugs, hospital stays, days in hospital, and location of death. Compared to controls, long-lived siblings presented a lower risk of dying from dementia ( p = 0.020) and ill-defined conditions ( p = 0.030).

Conclusions:

In many aspects long-lived siblings end their lives similar to sporadic long-livers, with the important exception of lower dementia risk during the last 5 years of life. These results suggest that long-lived siblings are excellent candidates for identifying environmental and genetic protective factors of dementia.
Getting Insight to the Lived Emotional Experience of People with Alzheimer’s Disease Shortly After Diagnosis: A Phenomenological Approach
Authors: Gamm Simone , Ummel Deborah , Vasil Nancy , Grenier Sébastien
Published: May 2024

Background:

A diagnosis of Alzheimer’s disease (AD) is a crucial moment in an individual’s existence and represents a major life change that often results in psychological distress, diminish of perceived quality of life, and loss of independence. It is important to better understand the emotional experience of people with dementia to intervene according to their specific needs.

Objective:

The aim of the research was to get insight to the emotional experience of people with AD shortly after its discovery and the consequences thereof.

Methods:

A qualitative exploratory design was engaged, and in-depth interviews were conducted with ten French-speaking participants over 70 years recently diagnosed. Interviews were guided by Heideggerian phenomenology about movements in the worldview of individuals. The transcribed data was subjected to interpretative phenomenological analysis.

Results:

Following the diagnosis, participants experienced either shock or denial. Emotions felt were unpleasant and disturbing for most of them. Especially when participants were confronted with news concerning the illness, they experienced incomprehension. They engaged in an oscillatory motion of connection and disconnection to establish new meanings of their worldview. Thinking about the past seemed to diminish their worries, to reinforce the possibility to fulfil a significant place in their existence and to maintain their autonomy.

Conclusions:

When participants could express their emotional experience and their concerns, they regained a sense of control in their life that seemed du reduce their distress. With this insight, intervention could be adapted to the specific needs of people with AD to enhance their self-determination and quality of life.
Novel Panel of Long Noncoding RNAs as Diagnostic Biomarkers for Amnestic Mild Cognitive Impairment in Peripheral Blood
Authors: Wang Tao , Zhang Wei , Maclin Joshua M.A. , Xu Hua , Hong Bo , Yan Feng , Liu Yuanyuan , He Haining , Liang Huafeng , Li Chunbo , Fang Yiru , Xiao Shifu
Published: May 2024

Background:

Long noncoding RNAs (lncRNAs) regulate the pathogenesis of Alzheimer’s disease (AD).

Objective:

To identify lncRNAs in the peripheral blood as potential diagnostic biomarkers for amnestic mild cognitive impairment.

Methods:

In the discovery group, a microarray was used to screen for significant differences in lncRNA expression between patients with mild cognitive impairment (MCI) caused by AD and normal controls (NCs) ( n = 10; MCI, 5; NC, 5). Furthermore, two analytic groups were assessed (analytic group 1: n = 10; amnestic MCI (aMCI), 5; NC, 5; analytic group 2: n = 30; AD, 10; aMCI, 10; NC, 10) and finalized in the validation group ( n = 150; AD, 50; aMCI, 50; NC, 50). In the analytic and validation groups, real-time quantitative reverse-transcription polymerase chain reaction was used to identify differentially expressed lncRNAs between the aMCI and NC groups.

Results:

We identified 67 upregulated and 220 downregulated lncRNAs among the expression profiles. The panel with lncRNAs T324988, NR_024049, ENST00000567919, and ENST00000549762 displayed the highest discrimination ability between patients with aMCI and NCs. The area under the receiver operating characteristic curve of this combined model was 0.941, with a sensitivity of 92.00% and specificity of 84.00%.

Conclusions:

This study reports on a panel of four lncRNAs as promising biomarkers to diagnose aMCIs.
Prediction of Amyloid Positivity in Patients with Subcortical Vascular Cognitive Impairment
Authors: Moon Hasom , Ham Hongki , Yun Jihwan , Shin Daeun , Lee Eun Hye , Kim Hee Jin , Seo Sang Won , Na Duk L. , Jang Hyemin
Published: May 2024

Background:

Amyloid-β (Aβ) commonly coexists and impacts prognosis in subcortical vascular cognitive impairment (SVCI).

Objective:

This study aimed to examine the differences in clinical and neuroimaging variables between Aβ-positive and Aβ-negative SVCI and to propose a prediction model for Aβ positivity in clinically diagnosed SVCI patients.

Methods:

A total of 130 patients with SVCI were included in model development, and a separate cohort of 70 SVCI patients was used in external validation. The variables for the prediction model were selected by comparing the characteristics of the Aβ-negative and Aβ-positive SVCI groups. The final model was determined using a stepwise method. The model performance was evaluated using the receiver operating characteristic (ROC) curve and a calibration curve. A nomogram was used for visualization.

Results:

Among 130 SVCI patients, 70 (53.8%) were Aβ-positive. The Aβ-positive SVCI group was characterized by older age, tendency to be in the dementia stage, a higher prevalence of APOE ɛ4, a lower prevalence of lacune, and more severe medial temporal atrophy (MTA). The final prediction model, which excluded MTA grade following the stepwise method for variable selection, demonstrated good accuracy in distinguishing between Aβ-positive and Aβ-negative SVCI, with an area under the curve (AUC) of 0.80. The external validation demonstrated an AUC of 0.71.

Conclusions:

The findings suggest that older age, dementia stage, APOE ɛ4 carrier, and absence of lacunes may be predictive of Aβ positivity in clinically diagnosed SVCI patients.
How to Cure Alzheimer’s Disease
Authors: Przybyszewski Andrzej W. , Chudzik Artur
Published: May 2024

There has been a lot of buzz surrounding new drug discoveries that claim to cure Alzheimer’s disease (AD). However, it is crucial to keep in mind that the changes in the brain linked to AD start occurring 20–30 years before the first symptoms arise. By the time symptoms become apparent, many areas of the brain have already been affected. That’s why experts are focusing on identifying the onset of the neurodegeneration processes to prevent or cure AD effectively. Scientists use biomarkers and machine learning methods to analyze AD progressions and estimate them “backward” in time to discover the beginning of the disease.
Pimavanserin’s Safety Profile: Insights from a Phase 3b Clinical Trial
Authors: Yunusa Ismaeel
Published: May 2024

The recent Alva et al. Phase 3b study on pimavanserin use in older adults with neurodegenerative diseases (NDDs), specifically including Alzheimer’s disease, vascular dementia, Parkinson’s disease (with or without dementia), frontotemporal dementia, and dementia with Lewy bodies, provides important new data on its safety for managing neuropsychiatric symptoms in this population. This commentary on the study further examines the findings within the broader context of antipsychotic therapy as it has evolved from chlorpromazine to pimavanserin in a continuous search for greater safety. Comparing pimavanserin’s safety and efficacy profile with historical data and regulatory milestones provides a nuanced perspective for clinicians regarding the significance of the drug’s known advantages over prior antipsychotic treatments. More research is needed to determine the full potential of pimavanserin to improve neuropsychiatric symptoms in older adults with NDDs.
Funai sob Bolsonaro
Authors: Nóbrega Luciana Nogueira
Published: May 2024

Desde a campanha presidencial de 2018, Jair Bolsonaro anunciava para diversos públicos que, se eleito, não demarcaria mais um centímetro de terra indígena. Ao iniciar seu mandato, em 2019, buscou colocar em prática uma nova relação entre o Estado e os povos indígenas, atingindo principalmente o núcleo duro da política indigenista brasileira: a Fundação Nacional do Índio (Funai)[1]. Nesse contexto, este artigo visa a analisar as políticas executadas pela Funai entre 2019 e 2022 à luz da legislação nacional e internacional, baseando-se, para tanto, no estudo sistemático de matérias jornalísticas, de instrumentos normativos infralegais, de manifestações dos povos indígenas e no estudo de caso sobre as ações da Funai em uma ação judicial específica. A atuação da entidade indigenista sob Bolsonaro configura um tipo de violência institucional, ainda não definido em lei; um tipo mais direto, uma vez que, nesse caso, a missão institucional do órgão passa a ser invertida. É a “cupinização” que corrói por dentro as estruturas, os aparatos, os procedimentos, as normas, as rotinas institucionais, tornando a Funai não apenas uma instância obsoleta e ineficiente em termos de execução, mas, ao contrário, uma instituição extremamente eficiente no seu novo mister: favorecer grupos contrários aos interesses dos povos indígenas.
 
[1] Utilizamos, aqui, a nomenclatura anterior da atual Fundação Nacional dos Povos Indígenas, já que estamos retratando um período histórico específico (entre 2019 e 2022).
THE BASIS OF THE FORMATION OF THE STRUCTURE OF TRANSPORT AND INTERCHANGE NODES WITH A SYSTEM OF SERVICE FACILITIES
Authors: Abdulhani Mustafa
Published: May 2024

In the article, the author conducted an analysis of scientific researches on the organization of the structure of service facilities within transport interchanges. It was found that there are a number of works devoted specifically to transport and interchange nodes without a service structure. Such researches has been done for airports, railway stations and bus stations. There are several works devoted to the organization of service facilities within the transport hubs of urban public transport and airports in the structure of aerotropolises. There are several researches devoted to general proposals for the organization of ancillary service facilities in locations of public activity.
Based on the research, the author made a number of proposals for the formation of transport hubs within the city. Among other things, the principles of the formation of transport hubs, the main conditions for their location in the city and possible restrictions on their location are described.
Among the analyzed works, there was no formulation of principles for organizing service facilities in the structure of transport hubs. Further research by the author will be directed in this direction.
RELEVANCE AND PROBLEMS OF DESIGNING POST-OPERATIVE REHABILITATION CENTERS FOR ARMED FIGHTERS
Authors: Tkachuk Olga , Serohin Yurii
Published: May 2024

At the time when Ukraine is fighting for its independence, many of its defenders receive injuries of varying degrees of severity during the hostilities. Of course, they are provided with the first qualified and specialized medical care in military hospitals and specialized medical facilities. But the rehabilitation of military personnel is of great importance for the full restoration of their functions and the opportunity to fully work and livе in society. While there are no projects for the complete reconstruction of the destroyed cities of Ukraine, it is necessary to take priority steps aimed at a number of modern problems, among which the design of rehabilitation centers that provide not only physical rehabilitation, but also psychological rehabilitation is important.
ANALYSIS OF DESIGN AND CONSTRUCTION PRACTICE MASS HOUSING
Authors: Yezhov Serhii
Published: May 2024

The article reveals the basics of the formation of residential buildings of mass industrial construction. Design and construction practice and typological features of residential buildings are analyzed. Proposals for the reconstruction and reconstruction of mass housing in Ukraine are being considered. The organization of housing with the use of promising architectural and structural systems and the formation of housing complexes is revealed. Modern trends in the architectural design of multi-story residential buildings are considered, and proposals for the complex formation of housing with targeted development of residential structures are provided.
Improving Documentation Quality and Patient Interaction with AI: A Tool for Transforming Medical Records — An Experience Report
Authors: Basei de Paula Pedro Angelo , Berger Matheus Nespolo , Bruneti Severino João Victor , Ribeiro Karen Dyminski Parente , Loures Fillipe Silveira , Todeschini Solano Amadori , Roeder Eduardo Augusto , Lenci Marques Gustavo
Published: May 2024

The quality of medical records is paramount for effective patient care, yet it is often compromised by the need for doctors to type information during consultations. This practice not only consumes valuable time that could be better spent on patient interaction but also increases the risk of medical errors due to repetitive copy-pasting. This paper examines the implementation and impact of Voa, an AI-driven tool designed to transform audio from medical consultations into optimized clinical documents. Utilizing automatic transcription technologies like Whisper and generative artificial intelligence, Voa generates accurate and comprehensive medical records from consultation audio. The study, conducted from February to May 2024, assessed Voa's effectiveness through metrics such as the number of anamneses generated, user adoption rates, and activation rates. Results indicate a significant increase in both document generation and user adoption, reflecting growing acceptance and confidence in the platform. The findings highlight Voa's potential to improve documentation quality, reduce medical errors, and enhance doctor-patient interactions, ultimately promoting more human-centered healthcare practices. This experience report underscores the transformative impact of Voa in medical documentation, advocating for broader adoption of such technologies in clinical settings.
A Case Report of Situs Inversus Totalis with Ventricular Septal Defect: Flipped Physiology
Authors: Darbari Anshuman , Rawat Shubham Singh , Kumar Barun
Published: May 2024

Dextrocardia with situs inversus (situs inversus totalis) is a rare congenital condition characterized by the abnormal positioning of the heart and other organs in the thoracic and abdominal cavities. When combined with a ventricular septal defect (VSD), it presents unique challenges in diagnosis and management. Here, we present a case report of a patient with dextrocardia, situs inversus, and a peri-membranous VSD, highlighting the diagnostic process and discussing available treatment options.
A Study on Development Disparities in Central Papua Province: Assessing Per Capita Income Disparities and Recommending Equitable Development Strategies
Authors:   Economics Department, Cenderawasih University, Iek Mesak , Purwadi Marsi Adi ,   Economics Department, Cenderawasih University, Titalessy Pisi Bethania ,   Economics Department, Cenderawasih University
Published: May 2024

This research is a study of development disparities between regions in Central Papua Province which aims to (1) know and analyze disparities in per capita income between regions in Central Papua Province; and (2) analyze and prepare recommendations regarding efforts to overcome development disparities between regions in Central Papua Province. Data and information gathered from various regions undergo processing and examination through quantitative and qualitative methods. These approaches encompass evaluating factors like per capita income, employment across sectors, savings rates, urbanization levels, literacy rates, life expectancy, infant mortality rates, along with offering policy suggestions based on research outcomes. The data utilized is sourced from governmental bodies like BPS, Bappeda, Dispenda, as well as non-governmental institutions such as Bank Indonesia. Research analysis involves growth assessment, disparity examination, and descriptive statistical analysis. The result shows that over the past decade (2013-2022), there has been significant economic inequality among districts/cities within Central Papua Province region, indicating unequal economic growth across regions. Efforts that need to be made by Regency/City Governments in Central Papua Province are to improve the performance of community welfare aspects which are considered capable of driving equitable development in each region
The Role of Flexible Work Arrangement, Job Embeddedness, and Work-Life Balance in Reducing Turnover Intention: Study on Millennials and Generation Z Employees
Authors:   Brawijaya University, Rosita Ferriyal , Noermijati Noermijati ,   Brawijaya University, Margono Margono ,   Brawijaya University, Susilowati Christin ,   Brawijaya University
Published: May 2024

Millennials and Generation Z, as the largest demographics entering the workforce, were anticipated to drive national progress. However, despite their significant numbers, many of them are experiencing high turnover rates. This study investigates the role of flexible work arrangements, job embeddedness, and work-life balance in suppressing turnover intention among millennials and Generation Z in multifinance companies at Jakarta headquarters. This research is quantitative research with non-probability sampling. The questionnaire was distributed to 280 respondents. The data analysis technique uses Partial Least Square (PLS) analysis tools. The results indicate that (1) flexible work arrangement has a significant negative impact on turnover intention; (2) flexible work arrangement has a significant positive impact on job embeddedness and work-life balance; and (3) flexible work arrangement has a significant negative impact on turnover intention which is partially intervened by job embeddedness and work-life balance. It is suggested for multi-finance companies to optimize flexible work arrangement practices by implementing work-life balance and job embeddedness to reduce turnover intention among millennials and Generation Z
ВИКЛИКИ ТА КЛЮЧОВІ НАПРЯМИ ВІДНОВЛЕННЯ ЕКОНОМІКИ УКРАЇНИ У ПОСТВОЄННИЙ ПЕРІОД
Authors: Богун В. С.
Published: May 2024

У статті досліджено сучасні виклики та основні тенденції відновлення й відбудови економіки держави у поствоєнний період. Проаналізовало економічні показники до початку повномасштабного вторгнення та в період перебування країни в стані війни. Визначено, що основні ризики економічної динаміки й сповільнення росту пов'язані з затяжною тривалою війною, міжнародною глобальною економічною рецесією, нестабільним становищем підприємств, порушенням глобальних виробничих ланцюгів. Криза національної економіки та негативні тенденції, що зумовлені війною стають чинником появи тривалих негативних трендів. До ключових загроз віднесено корупцію, демографічну ситуацію, невизначеність, фінансове законодавство, ресурси та політичну нестабільність. Обґрунтовано, що для реагування на прояви соціально-економічної кризи має бути підвищення стійкості та раннє відновлення, що передбачає здійснення таких кроків як: підтримка уряду міжнародними партнерами України; зміцнення інститутів громадянського суспільства та місцевих громад; збереження і розвиток започаткованої тенденції на мінімізацію регуляторного впливу владних інституцій на операційне функціонування економіки; зміна цілей структурної економічної політики держави; повоєнне прискорене економічне зростання та розвиток. Акцентовано увагу на фінансовій й гуманітарній підтримці зарубіжних держав-партнерів. Для збалансованого плану відбудови вбачається важливим дотримуватися відповідної етапності вживаних заходів. Наголошено на позитивному впливі щодо темпів соціально-економічного розвитку й зниження трансакційних, трансформаційних витрат діяльності регуляторних структур публічного сектора. Обґрунтовано ключові напрями відновлення зруйнованої після війни національної економіки.
РОЗВИТОК ЕКОСИСТЕМИ ІННОВАЦІЙ В УМОВАХ ЦИФРОВОЇ ТРАНСФОРМАЦІЇ
Authors: Жидик Я. О.
Published: May 2024

У статті розглянуте явище цифровізація та інновації, які відіграють ключову роль у розвитку національних економік, забезпечуючи стрімке зростання продуктивності та конкурентоспроможності. Робота спрямована на аналіз теоретичних та методичних аспектів цифрової трансформації для вдосконалення функціонування вітчизняної екосистеми інновацій. Основна теза полягає в тому, що інтенсифікація цифрових трансформацій є критичною для розвитку економічних переваг України на глобальному ринку. У статті використано комбінацію кількісного та якісного аналізу, включаючи вивчення наукової літератури, класифікацію інновацій та оцінку поточного стану цифровізації в Україні. У результаті дослідження було виділено ряд рекомендацій, які необхідно впровадити задля подальшого процесу цифровізації в національній економіці.
СТРУКТУРА ІНТЕЛЕКТУАЛЬНОГО КАПІТАЛУ СУЧАСНИХ ІНЖИНІРИНГОВИХ СЕРВІСІВ
Authors: Левіт О. О.
Published: May 2024

Проблеми управління інтелектуальним капіталом з урахуванням змін технологічних ландшафтів турбують багатьох вчених і є актуальними у галузях з наукомісткою працею. Метою цієї розвідки є узагальнити матеріал щодо класифікації інтелектуального капіталу в контексті підприємства з надання інжинірингових послуг, і запропонувати удосконалену модель його структури з виділенням головних елементів. Наведено обґрунтування стратифікації інтелектуального капіталу на статичний та змінний шари. Запропоновано розглянути дефініцію інформаційно-технологічного капіталу та відокремити його у структурі як окрему домінанту. Наведений аналіз значущості клієнтського капіталу у контексті надання інжинірингових сервісів в ланцюзі створення нової цінності. Сформульовано можливості подальших наукових досліджень, які забезпечує така інтерпретація структури інтелектуального капіталу.
The Study Examines the Marketing Strategies of Goat and Sheep Farming Businesses in CV. Fajar Randu
Authors: K A Usman  , F Hasan  , S Mulatsih
Published: May 2024

The livestock sector has a very broad and systematic scope. Within the livestock business, the marketing function plays a crucial role. Marketing is based on the basic marketing code and is designed to emulate or function as part of a marketing system. Goat and sheep farming businesses are in great demand, both for daily needs and for religious celebrations. CV Fajar Randu's goat and sheep farming business is a farm that provides goat and sheep buying and selling, aqiqah, and qurban services.The types of goats and sheep raised here are local kacang goats and sheep, with varying prices offered. This research aims to identify the marketing and financial channels of CV Fajar Randu. The research was carried out in August-April 2023. The methods used in collecting data were interviews, observation, and questionnaires, while determining the research sample used a purposive sampling technique. The research results show that there are two marketing channels that occur, namely level I channels and level II channels and the marketing functions carried out by CV Fajar Randu are the exchange function and the physical supply function. Level I marketing channels have the smallest marketing margin, the largest farmer's share, and the most efficient marketing channel. The SWOT analysis results indicate that CV Fajar Randu is in quadrant I. The research results also show that the environmental conditions of CV Fajar Randu are good. According to the research findings, the CV Fajar Randu farm can employ SO as an alternative strategy. In conclusion Level I marketing channels is the most efficient ones