bluuebunny/crossref_metadata_2025 huggingface dataset:
Induction and rationalization of supramolecular chirality in a Zn(II)porphyrin dimer using chiral substrates: Role of substrates in the architectural selectivity
Authors: Saha Bapan , Chandel Dolly , Pal Chandrani , Rath Sankar Prasad
Published: December 2022

A flexible Zn(II)porphyrin dimer has been utilized as an efficient host for the selective binding of several diols and diamines as substrates. Stepwise formation of a 1:1 host-guest polymer and 1:2 host-guest monomer via intermolecular self-assembling and disassembling processes, has been demonstrated with a series of diamine/diols. Transfer of chirality from the molecular to the supramolecular level has been rationalized with structural elucidation. The formation of the 1:1 host-guest polymer displays a bisignate CD couplet. X-ray structure demonstrates the presence of both clockwise and anticlockwise conformers, however, the conformer formed as per pre-organization in the substrate chirality contributes more towards the overall CD couplet in solution. The addition of the substrate in excess leads to the inversion of the CD couplet due to the formation of the monomeric complex. Architectural selectivity has been illustrated for the 1:1 host-guest complexation by simply tuning the length of the substrates. Crystallographic characterizations revealed linear 1D polymeric structures for the 1:1 host-guest complexes with longer diamines while shorter substrates stabilize cyclic dimer via intermolecular H-bonding between the urea bridge (cis-NH-CO-) of the two porphyrin dimers. Interestingly, the molecular structure of 1:1 host-guest complexes with diols displays a linear polymer despite the shorter length of the substrates. Along with weaker coordination of the alcoholic oxygen towards the Zn(II) ion, the presence of bulky substituents at the coordinating sites of the diols renders the formation of intermolecular H-bonding interactions. Thus, the nature of metal ion and their binding affinity towards the substrate, host-guest size complementarity, and the bulk of the substituents contribute cumulatively towards the architectural selectivity. The cyclic dimers display larger upfield shifts of the substrate protons in the 1H NMR spectra as compared to the linear polymers. Moreover, the computational calculations further substantiate the experimental observations.
A note on (ψ+,ψ−)-derivations of Banach–Jordan systems with nonzero socle
Authors: Marhnine Hassan , Zarhouti Chafika
Published: December 2022

The main objective of this research paper consists in introducing the concept of [Formula: see text]-derivations acting on Banach–Jordan pairs and Banach–Jordan algebras and giving an automatic continuity result of the operators in question under some algebraic conditions. Concretely, we prove that [Formula: see text] -derivations defined from a Banach–Jordan pair [Formula: see text] into a strongly prime Banach–Jordan pair [Formula: see text]  are automatically continuous under the assumptions that the socle [Formula: see text]  is nonzero and [Formula: see text]  is an isomorphism from [Formula: see text]  into [Formula: see text]. Similar results for Banach–Jordan algebras hold to be true.
Nurturing Teaching Methods of Entrepreneurship in the Development of An Entrepreneurial University
Authors: Sidrat Sawsen , Chaudhry Peggy E. , Chaudhry Sohail S.
Published: December 2022

The nurturing of an entrepreneurial university is essential since it creates an important place to teach the key themes of entrepreneurship. This paper provides a literature review and discusses the various definitions of the entrepreneurial university and its development factors. This paper uses [Kearnay’s (1999). Enterprising Ways to Teach and Learn, a series of books, Enterprise Principles. Enterprise Design Associates. Tasmania, Australia: North Hobart] pedagogical approach on the development of the entrepreneurial university to create an empirical survey administered to 250 university professors in Tunisia. The results of this study illustrate that Kearnay’s pedagogical approach [Kearney, P (1999). Enterprising Ways to Teach and Learn, a series of books, Enterprise Principles. Enterprise Design Associates. Tasmania, Australia: North Hobart] (responsive, experiential, reflective, and cooperative pedagogy) positively influences the development of the entrepreneurial university. We conclude with an original teaching method framework to cultivate an entrepreneurial spirit in university students to facilitate an entrepreneurial university.
AN ALTERNATIVE METHODOLOGY TO MONITOR CHRONIC AND TRANSIENT POVERTY IN INDIA
Authors: BALAJI M. , DASH U.
Published: December 2022

The economic growth in India has been impressive in the last few decades, yet it continues to be a home for millions of poor. The poverty measures debate across the developing world has generated more heat than light as there is no consensus on constructing the poverty line. Characterization of poverty and heterogeneity of the poor needs more profound understanding and investigation. This paper attempts to provide an alternative framework to track Chronic and Transient poverty through decile density analysis and the Chronic-Transient Poverty Ratio by applying the Kernel Density function for the National Sample Survey Organisation’s consumer expenditure distribution in 55th, 61st, 66th, and 68th quinquennial rounds. An increase and a stagnant CTP ratio for urban and rural India implies that poverty reduction interventions are less impactful in rural India. A renewed thrust on poverty alleviation programmes is required in Urban India. Other developing and underdeveloped countries can emulate the proposed framework to analyze chronic and transient poverty conditions.
Vitruvius+: An Area-Efficient RISC-V Decoupled Vector Coprocessor for High Performance Computing Applications
Authors: Minervini Francesco , Palomar Oscar , Unsal Osman , Reggiani Enrico , Quiroga Josue , Marimon Joan , Rojas Carlos , Figueras Roger , Ruiz Abraham , Gonzalez Alberto , Mendoza Jonnatan , Vargas Ivan , Hernandez César , Cabre Joan , Khoirunisya Lina , Bouhali Mustapha , Pavon Julian , Moll Francesc , Olivieri Mauro , Kovac Mario , Kovac Mate , Dragic Leon , Valero Mateo , Cristal Adrian
Published: December 2022

The maturity level of RISC-V and the availability of domain-specific instruction set extensions, like vector processing, make RISC-V a good candidate for supporting the integration of specialized hardware in processor cores for the High Performance Computing (HPC) application domain. In this article,

1

we present Vitruvius+, the vector processing acceleration engine that represents the core of vector instruction execution in the HPC challenge that comes within the EuroHPC initiative. It implements the RISC-V vector extension (RVV) 0.7.1 and can be easily connected to a scalar core using the Open Vector Interface standard. Vitruvius+ natively supports long vectors: 256 double precision floating-point elements in a single vector register. It is composed of a set of identical vector pipelines (lanes), each containing a slice of the Vector Register File and functional units (one integer, one floating point). The vector instruction execution scheme is hybrid in-order/out-of-order and is supported by register renaming and arithmetic/memory instruction decoupling. On a stand-alone synthesis, Vitruvius+ reaches a maximum frequency of 1.4 GHz in typical conditions (TT/0.80V/25°C) using
GlobalFoundries
22FDX FD-SOI. The silicon implementation has a total area of 1.3 mm
2
and maximum estimated power of ∼920 mW for one instance of Vitruvius+ equipped with eight vector lanes.
Synthesis of Ni-WOx at Different H+ Concentrations for Hydrogen Evolution Reaction
Authors: Wang Yechen , Wang Yange , Bai Jing , Lau Woon-Ming
Published: December 2022

The development of efficient, durable, and inexpensive catalysts is a major challenge in achieving widespread application of hydrogen evolution reaction (HER). Herein, the Ni-WOx nanoparticles were prepared on nickel foam by hydrothermal and heat treatment. In particular, the nickel foam is not only used as a substrate, but also as a nickel source in an acidic environment to achieve the purpose of nickel doping. HCl is used to regulate the acidic environment, and its dosage will directly affect the phase and size of the material. By optimizing the usage of HCl, we demonstrate that the size of Ni-WOx nanoparticles decreased with the increase in HCl dosage. However, when the amount of HCl is too high, the nanoparticles will agglomerate and the crystalline phase of the material was also changed. When the usage of HCl is 300 μl, the optimized Ni-WOx has a smaller contact resistance and faster charge transfer rate, exhibiting excellent HER performance in alkaline media (the over-potentials is 96 mV at 20 mA cm−2 and outstanding durability over 10 h).
Sports Video Classification Framework Using Enhanced Threshold Based Keyframe Selection Algorithm and Customized CNN on UCF101 and Sports1-M Dataset
Authors: Ramesh M. , Mahesh K.
Published: December 2022

The computer vision community has taken a keen interest in recent developments in activity recognition and classification in sports videos. Advancements in sports have a broadened the technical interest of the computer vision community to perform various types of research. Images and videos are the most frequently used components in computer vision. There are numerous models and methods that can be used to classify videos. At the same time, there no specific framework or model for classifying and identifying sports videos. Hence, we proposed a framework based on deep learning to classify sports videos with their appropriate class label. The framework is to perform sports video classification using two different benchmark datasets, UCF101 and the Sports1-M dataset. The objective of the framework is to help sports players and trainers to identify specific sports from the large data source, then analyze and perform well in the future. This framework takes sports video as an input and produces the class label as an output. In between, the framework has numerous intermediary processes. Preprocessing is the first step in the proposed framework, which includes frame extraction and noise reduction. Keyframe selection is carried out by candidate frame extraction and an enhanced threshold-based frame difference algorithm, which is the second step. The final step of the sports video classification framework is feature extraction and classification using CNN. The proposed framework result is compared with pretrained neural networks such as AlexNet and GoogleNet, and then the results are also compared. Three different evaluation metrics are used to measure the accuracy and performance of the framework.
Effect of PhenylEthanol Glycosides from Cistanche Tubulosa on Autophagy and Apoptosis in H22 Tumor-Bearing Mice
Authors: Qi Xinxin , Hou Xiaotian , Su Deqi , He Zhuanxia , Zhao Jun , Liu Tao
Published: December 2022

An effectual remedy for hepatocellular carcinoma (HCC) and knowledge of the mechanism are urgently needed. Researchers have found that CPhGs, an extract from Cistanche tubulosa (Schenk) Wight, had better antitumor effects, but its mechanism is still unknown. In the present study, using an H22 tumor-bearing mouse as a model, we investigated the antitumor effects of CPhGs and the effect of CPhGs on autophagy and apoptosis. Besides, we also discussed the role of autophagy with the help of HCQ and rapamycin. Our results show that CPhGs inhibit tumor growth and induce apoptosis and autophagy of tumor tissue. TUNEL staining displayed that tumor apoptosis rate increased after the intervention of CPhGs, and immunohistochemistry and western blot showed that cleaved-PARP and cleaved-caspase 3 were upregulated after the intervention of CPhGs, and these results were most pronounced in the high-dose group. Autophagy results revealed that CPhGs increased the number of autophagosomes, increased the level of LC3B-II, and decreased the level of p62. Finally, our results showed that excessive autophagy suppresses tumor growth, whereas inhibition of autophagy does the opposite, which indicated that CPhGs induced autophagic death in H22 hepatoma-bearing mice. These data altogether confirmed the involvement of apoptosis and autophagy in CPhGs treatment for HCC.
A Semiblind Receiver for a Two-Way UAV-Aided PIC System Based on the PARAFAC Model
Authors: Han Xi , Liu Yichen , Liu Qin , Wang Lijun , Li Zhengping
Published: December 2022

In this paper, we consider a two-way communication system using the unmanned aerial vehicle (UAV) as a relay (UAV-aided). This system eliminates impulse interference through an adaptive filter based on the least mean square (LMS) and uses the received signal transmitted by the UAVs to construct a parallel factor (PARAFAC) model. Based on the identifiability condition of the PARAFAC model, a pulse interference cancellation orthogonal pilot tensor (PIC-OPT) receiver without iteration is proposed. Our algorithm is also used in millimeter-wave to achieve the acquisition of channel information. Compared with the least squares method, the simulation results demonstrate the superiority of the proposed semiblind receiver in terms of the relative mean square error and bit error rate.
Field Deviation in Radiated Emission Measurement in Anechoic Chamber for Frequencies up to 60 GHz and Deep Learning-Based Correction
Authors: Shi Feng , Yan Liping , Yang Xuping , Zhao Xiang , Gao Richard Xian-Ke
Published: December 2022

The measurement of radiated emission (RE) in an anechoic chamber becomes very challenging at high frequencies, up to 60 GHz, because the scanning plane of the receiver is in measurement standard deviation from the actual wavefront. As a result, the RE intensity of the devices may be underestimated, resulting in electromagnetic interference. The deviation between the electric field at the far-field vertical scanning point and the actual wavefront is researched. Then, in an anechoic chamber, a hybrid deep learning amendment model of convolutional neural network (CNN) and transformer is proposed to correct the RE measurement at a 3 m distance. The results indicate that the correction is reliable, with an average error of 6.35% for a 3 m distance in a semianechoic chamber and less than 4.83% for other test scenarios. The proposed method provides a promising solution for RE measurement at a millimeter wave band in an anechoic chamber.
HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population
Authors: Bai Wei , Huang Xiaosheng , Shen Xiaoli , Ye Ye , Peng Shiming , Zhu Tianhui , Mei Shaoyi , Kuang Jiajie , Yu Sejie , Ma Xiaochen , Zhao Jun
Published: December 2022

Previous studies have shown that HLA gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between HLA-III gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 183 healthy controls were included in this study. Twenty-one single nucleotide polymorphisms (SNPs) of HLA-III genes (including HSP70-1, HSP70-2, HSP70-hom, TNF-α, TNF-β, C2, and CFB) were genotyped using the SNaPshot technique. Our study showed that the frequencies of G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β in the patient group were significantly higher than those in healthy controls (Corrected

P
 

P

c

=
0.040

,

OR
=
1.45

;

P

c

=
0.033

,

OR
=
1.45

;

P

c

=
0.045

,

OR
=
1.58

, respectively). The frequency of T allele at rs12190359 of HSP70-1 was significantly lower in PSS patients than those in healthy controls (

P

c

=
0.018

and

OR
=
0.10

). The frequencies of the CCT haplotype of HSP70-1 gene (rs1008438-rs562047-rs12190359) and the ACCCTTT haplotype of HSP70 gene (rs2227956-rs1043618-rs1008438-rs562047-rs12190359-rs2763979-rs6457452) were significantly lower in PSS patients than those in healthy controls (

P

c

=
0.024

,

OR
=
0.10

;

P

c

=
0.048

,

OR
=
0.10

, respectively). In conclusion, the G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β gene might be risk factors for PSS, while the T allele at rs12190359 of HSP70-1 gene and specific haplotypes of the HSP70-1 and HSP70 genes might be protective factors for PSS.
Experimental Investigation on Microstructure and Mechanical Properties of Friction Welded Dissimilar Alloys
Authors: Arulsamy Arun Negemiya , S Gnanasekaran , Murugesan Bakkiyaraj , Samuel Chelladurai Samson Jerold , Selvaraj Mohanraj Kishnan , Palanivel Vijayakumar , Balcha Gizachew
Published: December 2022

High-temperature dissimilar connections built of Inconel 718 and AISI 410 martensitic stainless steel (MSS) are widely used in a range of industries, including boiler construction, the chemical industry, aerospace, and nuclear. When compared to other materials, Inconel 718 and AISI 410 martensitic stainless steel offer superior strength and corrosion resistance under a variety of environmental conditions. The rotational speed was adjusted between 1100 and 1500 RPM, while the friction pressure, friction time, forging pressure, and forging duration were all kept constant during the testing. Five sets of testing were performed, with the resultant tensile strength (both room temperature and hot tensile) and Vickers Hardness being recorded for each set of trials. To assess the structural integrity of the joints, a detailed microstructural investigation, SEM-EDS, and XRD were performed at their interfaces. Mechanical properties were revealed to be high at 1300 RPM due to the small grain size at the interface region; ultimate tensile strength and hardness were determined to be 571 MPa and 423 HV, respectively, due to the small grain size at the interface region. Additionally, a pitting corrosion study has been conducted on dissimilar welded joints at optimum conditions, and their results were discussed and compared with base metals.
Integrated Direct Yaw Control and Antislip Regulation Mixed Control of Distributed Drive Electric Vehicle Using Cosimulation Methodology
Authors: Zhang Xinwen , Liang Hongbo , Wang Xiehui , Li Qiang
Published: December 2022

The improvement of handling and stability performance of Distributed Drive Electric Vehicle (DDEV) is analyzed, visualized, and designed by proposing and deploying the mixed control strategies in this paper including Direct Yaw Control (DYC), Antislip Regulation (ASR) and a novel Dual-mode Switching Control (DMSC). First, by drawing the phase trajectory stability domain, the vehicle stability limit boundary can be determined, which provides the basis for the lateral stability constraint of the vehicle. Then, the practicability and real time visualization of driving efficiency and timeliness of DDEV is achieved to reduce the margin of error for the desired torque value by employing the DYC strategy which uses a fuzzy PID algorithm. Furthermore, the ASR strategy which adopts the optimal slip rate algorithm to determine the requirement of desired torque value based on the different road conditions is used to reduce slip phenomenon effectively and to maintain handling control of DDEV. In response to different scenes especially conflict and coexistence between DYC and ASR, the DMSC strategy is applied to find a more suitable slip rate range by using the root mean square error method (REME). Finally, the cosimulation platform of ADAMS/Car and MATLAB/Simulink is built to simulate the mixed control strategies by integrating DYC, ASR, and DMSC. The simulation results show that the DMSC can effectively prevent DDEV from entering the dangerous limit driving state when turning and driving. The strategy has a more significant control effect needed to meet the requirements of the driving safety of the vehicle and handling stability. The DMSC is adopted and downloaded into the electronic control unit of our student type formula vehicle called Flash V6 which was designed and developed by a team of students, the ZUST ATTACKER Team.
Circulating Metabolic Markers Related to the Diagnosis of Hepatocellular Carcinoma
Authors: Xie Da , Zhang Guangcong , Ma Yanan , Wu Dongyu , Jiang Shuang , Zhou Songke , Jiang Xuemei
Published: December 2022

Primary liver carcinoma is the sixth most common cancer worldwide, while hepatocellular carcinoma (HCC) is the most dominant cancer type. Chronic hepatitis B and C virus infections and aflatoxin exposure are the main risk factors, while nonalcoholic fatty liver disease caused by obesity, diabetes, and metabolic syndrome are the more common risk factors for HCC. Metabolic disorders caused by these high-risk factors are closely related to the tumor microenvironment of HCC, revealing a possible cause-and-effect relationship between the two. These metabolic disorders involve many complex metabolic pathways, such as carbohydrate, lipid, lipid derivative, amino acid, and amino acid derivative metabolic processes. The resulting metabolites with significant abnormal changes in the concentration level in circulating blood may be used as biomarkers to guide the diagnosis, treatment, or prognosis of HCC. At present, there are high-throughput technologies that can quickly detect small molecular metabolites in many samples. Compared to tissue biopsy, blood samples are easier to obtain, and patients’ willingness to participate is higher, which makes it possible to study blood HCC biomarkers. Over the past few years, a substantial body of research has been performed worldwide, and other potential biomarkers have been identified. Unfortunately, due to the limitations of each study, only a few markers have been widely verified and are suitable for clinical use. This review briefly summarizes the potential blood metabolic markers related to the diagnosis of HCC, mainly focusing on amino acids and their derivative metabolism, lipids and their derivative metabolism, and other possible related metabolisms.
Aminotransferase Level and the Effects of Dual Antiplatelet in Minor Stroke or Transient Ischemic Attack: A post hoc Analysis of a Randomized Control Trial
Authors: Suo Yue , Pan Yuesong , Chen Weiqi , Jing Jing , Yan Hongyi , Li Hao , Liu Liping , Zhao Xingquan , Wang Yilong , Meng Xia , Wang Yongjun ,   on behalf of the CHANCE investigators
Published: December 2022

Introduction: This study was intended to evaluate whether the safety and efficacy of dual antiplatelet treatment in patients with minor ischemic stroke (MIS) or transient ischemic attack (TIA) could be modified by the aminotransferase level. Also, we sought to assess the interaction between aminotransferase level and CYP2C19 loss-of-function status on the efficacy of dual antiplatelet therapy. Methods: This study is a post hoc analysis of the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) study, a double-blinded randomized control trial. We included 5,133 patients with a complete workup of baseline alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. The primary outcome is stroke or TIA recurrence within 90 days. Cox proportional hazard models were used in the evaluation of the efficacy of antiplatelet treatment in patients with different aminotransferase levels and subgroups categorized by the aminotransferase level × CYP2C19 loss-of-function status. Results: The median age of all the included patients was 62 years; 66.3% of the patients were male. More recurrent stroke or TIA occurred in patients with elevated ALT and AST levels within 90 days compared to patients with normal ALT and AST levels (14.5 vs. 11.2%, p = 0.029). Dual antiplatelet treatment with aspirin and clopidogrel reduced recurrence compared with aspirin alone in patients with both normal (adjusted hazard ratio [HR], 95% confidence interval [CI]: 0.72 [0.60–0.86], p < 0.001) and elevated (adjusted HR [95% CI]: 0. 57 [0. 35–0. 92], p = 0. 020) ALT and AST levels (p = 0.64 for interaction). No significant difference in treatment efficacy on 90-day all-cause death or bleeding events was found. Conclusions: Dual antiplatelet treatment was safe for minor stroke or high-risk TIA patients with mildly elevated aminotransferase. Mild elevation of ALT or AST did not undermine the protective efficacy of the dual antiplatelet regimen in reducing recurrent stroke or TIA within 90 days after MIS or TIA. The interaction between the CYP2C19 loss-of-function allele carrier status and aminotransferase level on the efficacy of dual antiplatelet treatment was not observed.
Glans Penis Ischemia after Circumcision in a 15-Year-Old Patient Managed with Intravenous Pentoxifylline: A Case Report and a Diagnostic-Therapeutic Guideline Proposal
Authors: Arredondo Montero Javier , Antona Giuseppa , Ros Briones Raquel , Bronte Anaut Mónica , Bardají Pascual Carlos
Published: December 2022

Glans ischemia is an extremely infrequent complication characterized by a total or partial compromise in the penile arterial perfusion. A 15-year-old male patient suffered an episode of ischemia in the glans penis post-circumcision 24 h after surgery. Intravenous treatment with continuous perfusion of pentoxifylline was started for 4 days, with favorable evolution. Complete resolution was observed with no sequelae. There is no consensus on the best therapeutic management. The favorable evolution reported in most of the cases despite different therapeutic approaches leads us to think that the role of the treatments proposed so far is probably less than we believe. Additionally, we present a proposal for a diagnostic and therapeutic guide for this entity. Although the evidence in the literature is scarce and this guideline should be interpreted with caution, we believe that it can constitute a support resource for cases similar to ours.
Risk Factors for Fellow Eye Involvement in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy
Authors: Li Xinnan , Guo Taimin , Zhang Yurong , Liu Kaiqun , Xu Xiaoyu , Fu Yue , Liu Xiaoning , Ren Xin , Yang Hui
Published: December 2022

Introduction: The aim of the study was to investigate the possible risk factors for fellow eye involvement in patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods: A total of 113 patients with unilateral NAION attack were included and divided into two groups according to whether fellow eye involvement was present over a mean follow-up period of 2.70 years (P25–P75: 0.77–3.54 years). General characteristics (including age, sex, diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea syndrome [OSAS]) and ocular characteristics (including initial best-corrected visual acuity, initial visual field damage of the first eye, and the presence/absence of a crowded disc) were analyzed and compared between the two groups. Cox regression was used to assess the risk factors for fellow eye involvement. Results: During the follow-up period, 40 patients developed fellow eye involvement. The initial best-corrected visual acuity (p = 0.048) and mean deviation of the visual field (VF) (p = 0.039) of the first eye in patients with fellow eye involvement were worse than those in patients without it. Diabetes (HR = 3.06, 95% CI: 1.50, 6.26, p = 0.002) and increased VF damage (moderate vs. mild, HR = 2.92, 95% CI: 1.03, 8.25, p = 0.043; severe vs. mild, HR = 5.01, 95% CI: 1.65, 15.20, p = 0.004) were associated with a significantly increased risk of fellow eye involvement. In 57 patients with apnea-hypopnea index (AHI) data for further study, an AHI score ≥23.2 was also found to be a risk factor (HR = 3.36, 95% CI: 1.17, 9.69, p = 0.025). Conclusion: Diabetes, severer initial VF damage, and more severe OSAS were risk factors for fellow eye involvement in NAION. For patients with these risk factors, more intensive follow-ups might be warranted.
Timing to intubation COVID-19 patients: can we put it off until tomorrow?
Authors: Sternlicht Juliana Martes , Alencar Júlio Cesar Garcia de , Mauá Denis Deratani , Souza Heraldo Possolo de
Published: December 2022

Background: The decision to intubate COVID-19 patients receiving non-invasive respiratory support is challenging, requiring a fine balance between early intubation and risks of invasive mechanical ventilation versus the adverse effects of delaying intubation. Objective: Analyze the relationship between intubation day and mortality in COVID-19 patients. Methods: A unicentric retrospective cohort study considering all adult laboratory-confirmed SARS-CoV-2 infection consecutively admitted at a tertiary hospital between March 2020 and August 2020 requiring invasive mechanical ventilation. The primary outcome was all-cause mortality within 28 days after intubation, and a Cox model was used to evaluate the effect of time from onset of symptoms to intubation in mortality Results: A total of 592 (20%) adult consecutive patients out of 3020 admitted with COVID-19 were intubated during the study period. The median time from admission to intubation was one day (interquartile range, 0-3), and 310 patients (52%) who were intubated and mechanically ventilated deceased 28 days after intubation. Each additional day between the onset of symptoms and intubation was significantly associated with higher in-hospital death (adjusted hazard ratio, 1.018; 95% CI, 1.005-1.03). Conclusion: Among patients infected with SARS-CoV-2 who were intubated and mechanically ventilated, delaying intubation in the course of symptoms may be associated with higher mortality.
Low muscle mass in older adults and mortality: a systematic review and meta-analysis
Authors: Tanigava Nicolas Yamada , Santana Felipe Mendonça de , Premaor Melissa Orlandin , Pereira Rosa Maria Rodrigues
Published: December 2022

Sarcopenia comprises a loss of muscle function and muscle mass. So far, the association between loss of muscle mass and mortality in older adults is inconsistent. A meta-analysis was performed to assess whether muscle mass measured by appendicular skeletal muscle mass index (ASMI) is associated with higher mortality in older adults. Articles of interest were searched for in two databases (PudMed® and Embase®). Cohort and case-control studies reporting ASMI and mortality and enrolling community-dwelling adults aged 65 years or more were included. Nine articles were eligible and included for analysis (n=10,028). All but one study were considered of high quality by Newcastle-Ottawa Scale assessment. We calculated the standardized mean difference (SMD) for ASMI between dead and living individuals during follow-up across studies. A reduced pooled ASMI in individuals who died as compared to those who survived was found (ASMI SMD=-0.18, CI95% -0.23 to -0.12, REM). A meta-regression was performed including ASMI SMD, grip strength SMD, body mass index (BMI), sex, study quality, method used to assess ASMI, site of study and age. BMI and ethnicity were found to significantly impact the difference in ASMI between dead and living individuals. These results reinforce the prognostic importance of assessing muscle mass in older adults.
Esclerodermia linear em golpe de sabre em adolescente – um relato de caso
Authors: Cardoso Marina , Carvalho Marina  Hernandes , Fleck Flaviane Wendland , Copi Luana Rocco Pereira
Published: December 2022

A esclerodermia é uma doença de pele, que tem uma origem autoimune, como o próprio nome sugere, ocorre um progressivo enrijecimento da pele. A esclerodermia linear em ‘golpe de sabre’ é uma variante incomum e de causa incerta que está associada a uma atrofia focal progressiva craniofacial. Essa doença se manifesta principalmente em crianças, em alguns casos além de achados cutâneos, pode ocorrer uma comorbidade no sistema nervoso central. Esse relato descreve o caso de um adolescente (15 anos) com queixa do surgimento de uma mancha hipocrômica em região frontal com crescimento progressivo. O diagnóstico foi confirmado por capiaroscopia, exames físicos dermatológicos da região frontal afetada, biópsia incisional da pele e exames laboratoriais. O tratamento de escolha envolveu o uso de prednisona oral, associado ao uso de clobetasol tópico, obtendo-se resultados clinicamente satisfatórios com boa resposta e melhora significativa da hipocromia. Por ser tratar de uma enfermidade rara, esse relato objetiva demonstrar a importância de um diagnóstico precoce e tratamento clínico adequado para reduzir inflamações ativas da doença e morbidade, o que pode refletir de forma significativa na qualidade de vida de pacientes portadores dessa doença rara.
Perfil epidemiológico da Covid-19 em um município do interior do Estado de São Paulo
Authors: Leite Julia Gabas , Carvalho Letícia Gonçalves , Anjo Olavo Ferreira Lopes , Rays Harissa Padovez , Matta Nicolas Joseph Della , Rosa Ricardo Santaella
Published: December 2022

Desde a descrição dos primeiros casos de Covid-19 na China em dezembro de 2019, a doença se espalhou rapidamente por todo o globo. No Brasil o primeiro caso foi descrito no final de fevereiro de 2020, no estado de São Paulo, tornando-se o primeiro país da América do Sul a notificar um caso de Covid-19. Rapidamente a doença se disseminou pelo interior do país, atingindo em pouco tempo praticamente todas as cidades. Em Catanduva, cidade de médio porte da região noroeste paulista, os primeiros casos foram identificados no final do mês de março de 2020. Esse estudo tem o objetivo de demonstrar alguns aspectos epidemiológicos do comportamento da pandemia em um município de médio porte do interior do estado de São Paulo. MÉTODO: estudo descritivo transversal. Foram obtidos dados sobre o perfil clínico e epidemiológico dos pacientes diagnosticados com Covid-19 e residentes na cidade de Catanduva, no período de março a dezembro de 2020. Os dados foram obtidos dos bancos de dados e-SUS e Sistema de Informação da Vigilância Epidemiológica (SIVEP), fornecidos pela Secretaria de Saúde do município. A pesquisa foi aprovada pelo Comitê de Ética e Pesquisa (CEP) do Centro Universitário Padre Albino com número do protocolo 4.871.572. RESULTADOS: No período selecionado, foram notificados 5705 casos de Covid-19, sendo 5122 classificados como casos leves e 583 como casos graves (SRAG). Dentre os casos graves 186 evoluíram para óbito. A média de idade e a mediana foram diferentes na comparação entre os grupos, com os casos mais graves mostrando médias mais altas. Sexo feminino predominou nos casos leves e o masculino nos casos graves e óbitos. Os sintomas mais frequentes foram febre, tosse, dispneia e odinofagia. Comorbidades como cardiopatias, diabetes, obesidade e pneumopatias foram mais frequentes principalmente entre os casos graves e óbitos. Dentre os pacientes internados a taxa de óbito foi de 32,1%. Essa taxa aumenta para 50,5% para os pacientes que necessitaram de terapia intensiva e para 79,2% para os pacientes que necessitaram de intubação orotraqueal. CONCLUSÃO: os resultados apresentados no presente estudo se mostraram em conformidade com os achados na literatura e demonstraram o impacto que a pandemia causou e tem causado na saúde da população.
Influência do sistema de mensuração de desempenho na agilidade organizacional e na inovação aberta
Authors: Brüggemann Evellin Ramlow , Monteiro Januário José , Lunkes Rogério João
Published: December 2022

Este estudo analisar a influência do sistema de mensuração de desempenho na agilidade organizacional e na inovação aberta. O processo de coleta dos dados foi efetuado com gestores de empresas brasileiras listadas na Brasil, Bolsa, Balcão (B3). Foram obtidas 105 respostas válidas, e analisadas por meio da técnica de modelagem de equações estruturais. Os resultados mostram que o sistema de mensuração de desempenho interativo influencia positivamente na agilidade organizacional e na inovação aberta. Os achados revelam ainda que a agilidade organizacional medeia a relação entre o sistema de mensuração de desempenho interativo e a inovação aberta. Essas evidências contribuem para a literatura gerencial ao sugerir a agilidade organizacional como um fator importante (mediador) que reforça os efeitos do PMS na inovação aberta. Além disso, avança ao mostrar que a implementação de PMS interativo é um importante antecedente da inovação aberta.
O indígena como lugar comum nas disputas retóricas coloniais: uma abordagem comparativa dos relatos de Staden, Thevet, Léry e Knivet
Authors: Araújo Girleane Santos , Siega Paula Regina
Published: December 2022

Este artigo toma como objetos os relatos de Hans Staden, André Thevet, Jean de Léry e Anthony Knivet sobre suas passagens, no século XVI, pelas terras do que viria a ser o Brasil. Analisando comparativamente tais textos, observamos como as diferentes realidades histórico-culturais em concorrência na Europa moldaram perspectivas ora convergentes ora conflitantes sobre um mesmo tema: o indígena, seus hábitos e costumes. Para a análise, mobilizamos as ideias de topoi ou tópicas do discurso, baseando-nos em Hansen (2013; 2021), assim como a noção de lutas de representação, teorizada por Chartier (1991; 2002), articulando-as a estudos sobre a história e mentalidade coloniais, entre outros. Concluímos que, nos discursos dos viajantes, o lugar comum do indígena é sede de argumentação em prol do grupo ao qual pertence o enunciador do discurso, que lança mão de opiniões pré-concebidas e aceitas pela sua comunidade como verdadeiras.
Acidente vascular encefálico hemorrágico e linfoma difuso de grandes células B com infiltração na medula espinhal
Authors: Hora João Sergio Ignacio , Rangel Ivan Orlando Castellanos , Rodas Patrícia Alexandra Viteri , Pinheiro Guilherme de Lima
Published: December 2022

As neoplasias malignas de células linfoides surgem de células do sistema imunológico em diferentes estágios de diferenciação, resultando em amplos achados clínicos, morfológicos e imunológicos.
Teste de fadiga de preensão palmar usando contrações dinâmicas e EMG em crianças com espinha bífida
Authors: Franco Camila Scarpino Barboza , Martins Emanuela Juvenal , Lemos Tenysson Will , Mattiello-Sverzut Ana Claudia
Published: December 2022

A espinha bífida (EB) consiste no fechamento incompleto do canal espinhal que pode envolver protrusão da medula espinhal, meninges e raízes nervosas.
Síndrome de Leigh - abordagem do médico Fisiatra
Authors: Valverde Vinícius de Araújo , Silva Wagner Thales , Borgneth Lívia Rangel Lopes , Dorf Sandro Rachevsky
Published: December 2022

A síndrome de Leigh (SL) é uma doença neurodegenerativa congênita de base metabólica do grupo das mitocondriopatias, que cursa com perda motora gradativa, déficit de controle da cabeça e do tronco, hipotonia muscular, dificuldade de sucção e para a marcha, ataxia, disartria, disfagia, regressão intelectual, alterações oftalmológicas e distúrbios respiratórios.
Febre recorrente em paciente com lesão medular traumática aguda: um relato de caso
Authors: Nakamura Ahy Natally Sawaki , Eidam Maria Lígia , Souza Daniel Rubio de
Published: December 2022

Febre é uma ocorrência muito comum após a lesão medular (LM) aguda. Estima-se uma incidência variando entre 38,5 e 71,7%. Estes pacientes sofrem alteração do sistema nervoso autônomo (SNA) com desregulação do controle térmico corporal.
Amputação em membros inferiores de urgência em Goiás: estudo epidemiológico de 2013 a 2021
Authors: Oliveira Aline Lopes de , Carrijo Thiago Machado , Castro João Paulo Ferreira , Medeiros Rodrigo Parente
Published: December 2022

Amputação significa a extração de um membro de forma cirúrgica ou traumática. Estima-se que a incidência de amputação mundial varia entre 2,8 a 43,9/105 habitantes anos, sendo 85% realizadas em membros inferiores.
Análise de reabilitações físicas pós-COVID-19 aprovadas no Rio de Janeiro no primeiro semestre de 2022
Authors: Silva Danilo Vitorio Marques da , Moore Mario Alberto do Valle Rocha , Vasconcelos Gustavo Lucena Jordão de , Oliveira Vinicius Gomes Alves de , Camerano Neto Hélio Speranza , Oliveira Vinicius Loures de , Souza Viviane Fernandes Marques de
Published: December 2022

O primeiro semestre de 2022 foi o período de maior quantidade de casos de COVID-19 no estado do Rio de Janeiro. Com isso, as manifestações pós-agudas da infecção por SARS-CoV-2 também seguiram a mesma tendência de crescimento.
Taxa de desenvolvimento de torque dos músculos do cotovelo em pacientes com espinha bífida
Authors: Martins Emanuela Juvenal , Mattiello-Sverzut Ana Claudia , Franco Camila Scarpino Barboza , Lemos Tenysson Will de , Aagaard Per
Published: December 2022

Espinha bífida (EB) cística é o defeito congênito na coluna vertebral, medula espinhal e cérebro com consequente presença de déficits motores e sensoriais principalmente nos membros inferiores, os quais podem dificultar ou impedir a deambulação independente.
Entender para tratar: disciplina de Medicina da Dor como ferramenta no cuidado de pacientes complexos
Authors: Oliveira Lucas Maia Peclat de , Carvalho Paulo Sérgio Teixeira de , Oliveira Rafael Maia Peclat de
Published: December 2022

A dor é considerada o problema médico mais antigo, e é considerada desde os primórdios da humanidade uma entidade política, social e religiosa.
Patient Preferences for Pharmaceutical and Device-Based Treatments for Uncontrolled Hypertension: Discrete Choice Experiment
Authors: Kandzari David E. , Weber Michael A. , Poulos Christine , Coulter Joshua , Cohen Sidney A. , DeBruin Vanessa , Jones Denise , Pathak Atul
Published: December 2022

Background:

Discrete choice experiment is a survey method used to understand how individuals make decisions and to quantify the relative importance of features. Using discrete choice experiment methods, we quantified patient benefit–risk preferences for hypertension treatments, including pharmaceutical and interventional treatments, like renal denervation.

Methods:

Respondents from the United States with physician-confirmed uncontrolled hypertension selected between treatments involving a procedure or pills, using a structured survey. Treatment features included interventional, noninterventional, or no hypertension treatment; number of daily blood pressure (BP) pills; expected reduction in office systolic BP; duration of effect; and risks of drug side effects, access site pain, or vascular injury. The results of a random–parameters logit model were used to estimate the importance of each treatment attribute.

Results:

Among 400 patients completing the survey between 2020 and 2021, demographics included: 52% women, mean age 59.2±13.0 years, systolic BP 155.1±12.3 mm Hg, and 1.8±0.9 prescribed antihypertensive medications. Reduction in office systolic BP was the most important treatment attribute. The remaining attributes, in decreasing order, were duration of effect, whether treatment was interventional, number of daily pills, risk of vascular injury, and risk of drug side effects. Risk of access site pain did not influence choice. In general, respondents preferred noninterventional over interventional treatments, yet only a 2.3 mm Hg reduction in office systolic BP was required to offset this preference. Small reductions in office systolic BP would offset risks of vascular injury or drug side effects. At least a 20% risk of vascular injury or drug side effects would be tolerated in exchange for improved BP.

Conclusions:

Reduction in systolic BP was identified as the most important driver of patient treatment preference, while treatment-related risks had less influence. The results indicate that respondents would accept interventional treatments in exchange for modest reductions in systolic BP compared with those observed in renal denervation trials.
Application of thin foam dressing in pressure sore related to nasal wing medical devices in nasogastric feeding patients
Authors: Dong Xiangyan , Sun Jufang
Published: December 2022

Objective: To evaluate the effect of thin foam dressing on pressure sore related to nasal wing medical devices in nasal feeding patients and to provide a reference for the management of nutrition tube and provide a basis for the formulation of nursing practice guidelines for
medical devices. Methods: In this prospective study, 172 patients with nasogastric feeding and indwelling nutrition tube for more than 7 days were selected as the research objects. Among them, 86 were conscious and 86 were comatose. They were randomly divided into the thin foam dressing
group (intervention group) and the conventional group, and then observed for 7 days. During the study period: observe and record the occurrence of skin pressure sore on the alar of the nose every day; observe and record the respiratory frequency and oxygen saturation of patients every hour;
investigate the satisfaction of 86 sober patients and 52 nurses in our department on their clinical application. Results: The incidence of medical device-related pressure sore in the intervention group and the conventional group was 3.49% and 22.09%, respectively, with a statistically
significant difference (P < 0.05). The mean values of respiratory frequency and oxygen saturation in the intervention group were 21 times/min and 99%, respectively, while those in the routine group were 20 times/min and 99%, respectively, with no significant difference (P
> 0.05). In terms of comfort and economy, the satisfaction scores of the two groups were 93.77±2.46, 94.71±1.92, 95.67±2.04, and 94.30±2.31 respectively, with statistically significant difference (P < 0.05). In terms of aesthetics and operability, the
intervention group was not lower than the conventional group, with no statistically significant difference (P > 0.05). Conclusion: Compared with the conventional group, thin foam dressing can effectively prevent the occurrence of pressure sore related to the nasal wing medical
devices caused by long-term application of the nutrient tube in nasal-feeding patients. Its application has certain safety and economy and is worthy of clinical promotion.
Clinical effect of compound lidocaine cream on oropharyngeal flora under general anesthesia
Authors: Song Xi , Zhou Liufang , Tang Lin , Ma Zhuang , Mao Xincheng , Peng Junmin
Published: December 2022

To observe the effect of compound lidocaine cream on oropharyngeal flora under general anesthesia, the front-end tracheal tube or laryngeal mask was coated with 410 cases under general anesthesia were chosen as endotracheal intubation group (T) and Laryngeal mask group (L)
from Jan, 2022 to June, 2022. Both were separately grouped into blank control (M), liquid paraffin oil (P) and Compound lidocaine cream (C). Based on the grouping, patients’ throat swab samples were collected for bacterial culture through tracheal catheter. Oral normal flora and
pathogenic bacteria from M and P were compared and P >0.05 was considered statistically non-significant. By comparison of C, T and L group, their oral normal flora and pathogenic bacteria were obviously restrained. In conclusion, compound lidocaine cream was coated
on tracheal tube or laryngeal mask for patients under general anesthesia. This method will be helpful to improve oral problems from pathogenic bacteria and also to inhibit oral normal flora.