bluuebunny/crossref_metadata_2025 huggingface dataset:
Review: The liver bile acid‐binding proteins
Authors: Monaco Hugo L.
Published: May 2009

The liver bile acid‐binding proteins, L‐BABPs, formerly called the liver “basic” fatty acid‐binding proteins, are a subfamily of the fatty acid‐binding proteins, FABPs. All the members of this protein group share the same fold: a 10 stranded β barrel in which two short helices are inserted in between the first and the second strand of antiparallel β sheet. The barrel encloses the ligand binding cavity of the protein while the two helices are believed to be involved in ligand accessibility to the binding site. The L‐BABP subfamily has been found to be present in the liver of several vertebrates: fish, amphibians, reptiles, and birds but not in mammals. The members of the FABP family present in mammals that appear to be more closely related to the L‐BABPs are the liver FABPs and the ileal BABPs, both very extensively studied. Several L‐BABP X‐ray structures are available and chicken L‐BABP has also been studied using NMR spectroscopy. The stoichiometry of ligand binding for bile acids, first determined by X‐ray crystallography for the chicken liver protein, is of two cholates per protein molecule with the only exception of zebrafish L‐BABP which, due to the presence of a disulfide bridge, has a stoichiometry of 1:1. The stoichiometry of ligand binding for fatty acids, determined with several different techniques, is 1:1. An unanswered question of great relevance is the identity of the protein that in mammals performs the function that in other vertebrates is carried out by the L‐BABPS. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 1196–1202, 2009.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
An experimental wireless sensor network applied in engineering courses
Authors: Aguilar Leocundo , Licea Guillermo , García‐Macías J. Antonio
Published: May 2009

Wireless sensor networks (WSNs) are an emerging technology based on the progress of electrical and mechanical engineering, as well as computer science in the last decade. This paper presents our experiences in designing and developing a WSN using commercial‐off‐the‐shelf components and assembled in‐house. This WSN is used as a support tool for teaching in undergraduate engineering programs in Electronic and Computing, providing students a hands‐on experience with emphasis on embedded software design. © 2009 Wiley Periodicals, Inc. Comput Appl Eng Educ 19: 777–786, 2011
Multiresolution foliage for forest rendering
Authors: Deng Qingqiong , Zhang Xiaopeng , Yang Gang , Jaeger Marc
Published: May 2009

Plants are important objects in virtual environments. High complexity of shape structure is found in plant communities. Level of detail (LOD) of plant geometric models becomes important for interactive forest rendering. We emphasize three major problems in current research: the time consumption in LOD model construction and extraction, the balance between visual effect and data compression, and the time consumption in the communication between Central Processing Unit (CPU) and Graphics Processing Unit (GPU). We present a new foliage simplification framework for LOD model and forest rendering. By an uneven subdivision of the tree crown volume, the cost for LOD model construction is drastically reduced. With a GPU‐oriented design of LOD storage structure for foliage, the costly hierarchical traversal of a binary tree is replaced by a sequential lookup of an array. The structure also decreases the communication between the CPU and the GPU in rendering. In addition, Leaf density is introduced to adapt compression to the local distribution of leaves, so that more visually relevant details are kept. According to foliage nature (broad leaves or needles), higher compression are finally reached using mixed polygon/line models. This framework is implemented on virtual scenes of simulated trees with high detail. Copyright © 2009 John Wiley & Sons, Ltd.
Functional Dissection of a Multimodular Polypeptide of the Pikromycin Polyketide Synthase into Monomodules by Using a Matched Pair of Heterologous Docking Domains
Authors: Yan John , Gupta Shuchi , Sherman David H. , Reynolds Kevin A.
Published: May 2009

Working together or apart: Separating multimodular PKS enzymes into their respective monomodules by replacing the natural intraprotein linkers (illustrated in red in the figure) with a matched docking domain pair from a heterologous PKS system, leads to only small losses in overall in vivo polyketide product and increased efficiency at utilizing polyketide pathway intermediates to prime the biosynthetic process.

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The pikromyin polyketide synthase (PKS) in Streptomyces venezulae is comprised of a loading module and six extension modules, which generate the corresponding 14‐membered macrolactone product. PikAI is a multimodular component of this PKS and houses both the loading domain and the first two extension modules, joined by short intraprotein linkers. We have shown that PikAI can be separated into two proteins at either of these linkers, only when matched pairs of docking domains (DDs) from a heterologous modular phoslactomycin PKS are used in place of the intraprotein linker. In both cases the yields of pikromycin produced by the S. venezuelae mutant were 50 % of that of a S. venezuelae strain expressing the native trimodular PikAI. This observation provides the first demonstration that such separations do not dramatically impact the efficiency of the entire in vivo biosynthetic process. Expression of module 2 as a monomodular protein fused to a heterologous N‐terminal docking domain was also observed to give almost a tenfold improvement in the in vivo generation of pikromycin from a synthetic diketide intermediate. These results demonstrate the utility of DDs to manipulate biosynthetic processes catalyzed by modular PKSs and the quest to generate novel polyketide products.
Total Syntheses of a Conformationally Locked North‐Type Methanocarba Puromycin Analogue and a Dinucleotide Derivative
Authors: Michel Benoît Y. , Strazewski Peter
Published: May 2009

Locked in translation: Crucial insight into the ribosomal catalysis of peptide‐bond formation is expected to be gained from the target compounds, which feature conformational locking in a North‐type pucker, designed to interfere with the translation of the genetic code. The compounds were prepared from D‐ribose in 18 and 19 steps by a multi‐step synthetic route described here (see scheme).

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An original synthetic approach for the first synthesis of an enantiopure methanocarba puromycin (3′‐α‐aminoacylamino‐3′‐deoxyadenosine) analogue and its cytidine dinucleotide derivative is described. Each compound is conformationally locked in a North‐type pucker and exhibits both a pseudoaxial hydroxy group and a pseudoequatorial aminoacyl group. The syntheses were accomplished from D‐ribose in 18 and 19 steps, respectively, with key steps being a ring‐closing metathesis, a Luche reduction, a Simmons–Smith cyclopropanation, a Mitsunobu coupling, a Mattocks bromoacetylation, a regioselective and a stereoselective nucleophilic substitution, a chemoselective phosphoramidite coupling and a Staudinger–Vilarrasa coupling. Both molecules are being tested for peptidyl transfer efficiency in ribosomes for comparison with the peptidyl transfer kinetics of natural puromycin and other natural and synthetic ribosomal A site substrates.
Calculational Study of Fluoroammonium and Related Cations and Dications
Authors: Olah George A. , Prakash G. K. Surya , Rasul Golam
Published: May 2009

Structures as well as 15N and 19F NMR chemical shifts of a series of fluoroammonium ions were studied by ab initio/GIAO‐SCF, GIAO‐MP2 and GIAO‐CCSD(T) methods. Calculated 15N and 19F NMR chemical shifts correlate well with the experimental data. The relative stabilities as well as the charge of the central nitrogen atom of fluoro‐substituted tetrahedral ammonium ions were found to increase linearly with the increasing number of fluorine substituents due to their strong electron‐withdrawing inductive effect. Similarly the magnitude of 15N NMR chemical shifts also increase linearly with the increasing number of fluorine substituents in accord with the strong deshielding effect of fluorine. Structures as well as 15N and 19F NMR chemical shifts of yet experimentally unknown fluoroammonium dications were also computed.
Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates
Authors: Campbell Victoria E. , de Hatten Xavier , Delsuc Nicolas , Kauffmann Brice , Huc Ivan , Nitschke Jonathan R.
Published: May 2009

Systemic change: A system of transformations between helical structures was observed to be governed by interactions mediated by the electronic effects of substituents, entropic effects, the conformational preferences of organic building blocks, and the coordinative preferences of the metal ion. All of these effects were important, but all must be considered together to allow the prediction of the product observed (see scheme).

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A rigid, helical macrocycle that contains two copper(I) ions has been synthesized through subcomponent self‐assembly. Although it does not obey the “rule of coordinative saturation”, this macrocycle could be prepared through subcomponent substitution starting from a tri(copper(I)) helicate, in a reaction in which copper(I) was ejected. The macrocycle was observed to readily participate in a sequence of transformations between helical structures mediated by the electronic effects of substituents, entropic effects, the conformational preferences of organic building blocks, and the coordinative preferences of the metal ion. The thermodynamic parameters governing the interconversion of an “open” helicate and the “closed” macrocycle were determined through van ‘t Hoff analysis, allowing quantification of the entropic driving force for macrocyclization.
ChemInform Abstract: Structure and Aromaticity of B6H5+ Cation: A Novel Borhydride System Containing Planar Pentacoordinated Boron
Authors: Yu Hong‐Lang , Sang Rui‐Li , Wu Yun‐Ying
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Growth of Inter‐Lanthanide LaLn′O3 (Ln′: Y, Ho—Lu) Perovskites from Hydroxide Fluxes.
Authors: Bharathy M. , Fox Adam H. , Mugavero S. J. , zur Loye H.‐C.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Porous Bi2WO6 Thin Films as Efficient Visible‐Light‐Active Photocatalysts.
Authors: Zhang Li‐Wu , Wang Ya‐Jun , Cheng Han‐Yun , Yao Wen‐Qing , Zhu Yong‐Fa
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanochemical Synthesis of AlF3 with NH4F as Fluorinating Agent — Does It Work?
Authors: Scholz G. , Kemnitz E.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrodeposition of 3D Ordered Macroporous Germanium from Ionic Liquids: A Feasible Method to Make Photonic Crystals with a High Dielectric Constant.
Authors: Meng Xiangdong , Al‐Salman Rihab , Zhao Jiupeng , Borissenko Natalia , Li Yao , Endres Frank
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical and Chemical Oxidation of [Pt2(μ‐Pyrophosphite)4]4‐ Revisited: Characterization of a Nitrosyl Derivative, [Pt2(μ‐pyrophosphite)4(NO)]3‐.
Authors: Bennett Martin A. , Bhargava Suresh K. , Bond Alan M. , Bansal Vipul , Forsyth Craig M. , Guo Si‐Xuan , Priver Steven H.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient Organocatalyzed Direct Asymmetric Aldol Reactions of Hydroxyacetone and Aldehydes.
Authors: Wu Xiaoyu , Ma Zhixiong , Ye Zhengqing , Qian Shan , Zhao Gang
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Melatonin Receptor Agonist Ramelteon via Rh‐Catalyzed Asymmetric Hydrogenation of an Allylamine.
Authors: Yamashita Masayuki , Yamano Toru
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reduction of Alkyl Halides by Triethylsilane Based on a Cationic Iridium Bis(phosphinite) Pincer Catalyst: Scope, Selectivity and Mechanism.
Authors: Yang Jian , Brookhart Maurice
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electron‐Deficient Phosphines Accelerate the Heck Reaction of Electron‐Rich Olefins in Ionic Liquid.
Authors: Liu Shifang , Saidi Ourida , Berry Neil , Ruan Jiwu , Pettman Alan , Thomson Nick , Xiao Jianliang
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Enamides via Rh/C‐Catalyzed Direct Hydroacylation of Ketoximes.
Authors: Guan Zheng‐Hui , Huang Kexuan , Yu Shichao , Zhang Xumu
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Water‐Soluble Dendritic Phosphine Ligands and Their Application to Hydration of Alkynes in Aqueous Media.
Authors: Fujita Ken‐ichi , Kujime Masato , Muraki Takahito
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: From Metacyclophanes to Cyclacenes: Synthesis and Properties of [6.8]3Cyclacene.
Authors: Esser Birgit , Bandyopadhyay Arkasish , Rominger Frank , Gleiter Rolf
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Allylboration of Ketones with β‐Benzyloxy‐γ,γ‐difluoroallylboronate: Preparation of gem‐Difluorinated Homoallylic tert‐Alcohols.
Authors: Ramachandran P. Veeraraghavan , Chatterjee Anamitra
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient, Rapid, and Regioselective Bromination of Anilines and Phenols with 1‐Butyl‐3‐methylpyridinium Tribromide as a New Reagent/Solvent under Mild Conditions.
Authors: Borikar Sanjay P. , Daniel Thomas , Paul Vincent
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Dimethoxy(aminoalkoxy)borate Derived from (S)‐Diphenylprolinol as Highly Efficient Catalyst for the Enantioselective Boron‐Mediated Reduction of Prochiral Ketones.
Authors: Stepanenko Viatcheslav , Ortiz‐Marciales Margarita , Barnes Charles L. , Garcia Carmelo
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regio‐ and Stereoselective Ring‐Opening Reaction of Chiral Aziridines: A Facile Synthesis of Chiral β‐Amino Alcohols.
Authors: Higashiyama Kimio , Matsumura Masataka , Kojima Hiroshi , Yamauchi Takayasu
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Unsymmetrical Ketones via Simple C—H Activation of Aldehydes and Concomitant Hydroacylation of Vinyl Sulfonates.
Authors: Fitzmaurice Richard J. , Ahern Jenna M. , Caddick Stephen
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Regioselective Rearrangement of 2,3‐Diaryloxiranes into 2,2‐Diarylacetaldehydes Catalyzed by Ytterbium Porphyrin Complex, Yb(TPP)OTf.
Authors: Takanami Toshikatsu , Nakajima Shin‐ichiro , Nakadai Shoichi , Hino Fumio , Suda Kohji
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Molybdenum(VI)‐Catalyzed Direct Substitution of Allylic Alcohols with Nitrogen, Oxygen, and Carbon Nucleophiles.
Authors: Yang Hongwei , Fang Ling , Zhang Ming , Zhu Chengjian
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Domino Approach for the Synthesis of Multisubstituted Pyrroles via Gold/Silver‐Catalyzed Amination/Cycloisomerization of (Z)‐2‐En‐4‐yn‐1‐ols.
Authors: Lu Yuhua , Fu Xiaoping , Chen Haoyi , Du Xiangwei , Jia Xueshun , Liu Yuanhong
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Isatins with Active Methylene Compounds on Neutral Alumina: Formation of Knoevenagel Condensates and Other Interesting Products.
Authors: Chakrabarty Manas , Mukherjee Ratna , Arima Shiho , Harigaya Yoshihiro
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 9,9′‐Biphenanthryl‐10,10′‐bis(oxazoline)s and Their Preliminary Evaluations in the Friedel—Crafts Alkylation of Indoles with Nitroalkenes.
Authors: Lin Shuang‐zheng , You Tian‐pa
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of 1,2‐Bis(pyrazol‐1‐yl)benzene: “Modern” Cross‐Coupling vs. the “Classic” Nucleophilic Substitution Approach.
Authors: Ivashchuk Olga , Sorokin Vladimir I.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Vinylogous Nitroaldol (Henry) Reaction Using 3,5‐Diethyl‐4‐nitroisoxazole and Carbonyl Compounds.
Authors: Adamo Mauro F. A. , Suresh Surisetti
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design and Synthesis of Novel N′‐tert‐Butyl‐N′‐substitutedbenzoyl‐N‐ [dihydrobenzofuran(chroman)]carbohydrazide Derivatives as Potential Insect Growth Regulators.
Authors: Huang Zhiqiang , Zhao Qiqi , Huang Runqiu , Wang Qingmin
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Improved Condensation of 2‐Pyridyllithium Intermediates with Aldehydes: Application for the Synthesis of 2‐(Polyhydroxyalkyl)pyridines.
Authors: Comoy Corinne , Petrignet Julien , Banaszak Estelle , Chartoire Anthony , Fort Yves
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Poly(N‐bromo‐N‐ethylbenzene‐1,3‐disulfonamide) and N,N,N′,N′‐Tetrabromobenzene‐1,3‐disulfonamide as Efficient Reagents for the Synthesis of Quinolines.
Authors: Ghorbani‐Vaghei Ramin , Akbari‐Dadamahaleh Somayeh
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Base‐Induced Rearrangements of N‐Substituted 3‐Arylaminoisoxazol‐5(2H)‐ones to 2‐Arylaminoimidazo[1,2‐a]pyridines.
Authors: Baradarani M. M. , Khalafy J. , Khadivi S. , Marjani A. Poursattar
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 148. Synthesis and anti‐Tubercular Activity of 1‐Hydroxy‐3‐oxo‐6,7‐dihydro‐3H,5H‐pyrido [3,2,1‐ij]quinoline‐2‐carboxylic Acid N‐R‐Amides.
Authors: Ukrainets I. V. , Tkach A. A. , Grinevich L. A.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Synthesis of Quinazolinone Derivatives from Nitro‐Compounds with the Aid of Low‐Valent Titanium.
Authors: Dou Guolan , Wang Manman , Shi Daqing
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of the Pictet—Spengler Reaction to Aryl Amine‐Based Substrates Having Pyrimidine as a π‐Nucleophile: Synthesis of Pyrimidoquinolines with Structural Analogy to Benzonaphthyridines Present in Alkaloids.
Authors: Agarwal Piyush K. , Sharma Sudhir K. , Sawant Devesh , Kundu Bijoy
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthesis of Highly Substituted Imidazo[1,5‐a]pyrazine Derivatives by 3‐CR/2‐CR Sequence.
Authors: Shaabani Ahmad , Maleki Ali , Mofakham Hamid
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diversity‐Oriented Synthesis of Substituted Pyrazolo[4,3‐d][1,2,3]triazin‐4‐ones.
Authors: Meibom Daniel , Bauser Marcus , Meier Heinrich , Schneider Dirk , Svenstrup Niels , Haebich Dieter
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Generation of Phosphorus—Carbon Bonds via a Rearrangement of P(III) Esters Catalyzed by Trimethylhalosilanes.
Authors: Dabkowski Wojciech , Ozarek Alfred , Olejniczak Sebastian , Cypryk Marek , Chojnowski Julian , Michalski Jan
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: “Biologic” Level Structures Through Chemistry: A Total Synthesis of a Unimolecular Pentavalent MUCI Glycopeptide Construct.
Authors: Lee Dongjoo , Danishefsky Samuel J.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Synthesis of 1‐[(3,4‐Dimethoxyphenyl)methoxymethyl]‐6,7‐dimethoxyisoquinoline (Setigerine), a Naturally Occurring Alkaloid, and Some Derivatives of Papaverine.
Authors: Jacobs Jan , Tuyen Nguyen van , Markusse Peter , Stevens Christian V. , Maat Leendert , De Kimpe Norbert
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New Type of Vitamin E Glycoconjugates.
Authors: Hryniewicka A. , Walejko P. , Morzycki J. W. , Witkowski S.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of (‐)‐Berkelic Acid.
Authors: Wu Xiaoxing , Zhou Jingye , Snider Barry B.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Y2O3 Addition on the Crystal Growth and Sintering Behavior of YSZ Nanopowders Prepared by a Sol—Gel Process
Authors: Kuo Chih‐Wei , Shen Yun‐Hwei , Hung I‐Ming , Wen Shaw‐Bing , Lee Huey‐Er , Wang Moo‐Chin
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unusual Structures and Reactivity of Mixed Metal Cluster Complexes Containing the Palladium/Platinum Tri‐t‐butylphosphine Grouping
Authors: Adams Richard D. , Captain Burjor
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Marine Natural Products: Synthetic Aspects
Authors: Morris Jonathan C. , Phillips Andrew J.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Hydrogen Transfer Reactions over Supported Copper Catalysts Leading to Simple, Safe, and Clean Protocols for Organic Synthesis
Authors: Zaccheria Federica , Ravasio Nicoletta
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Opening New Avenues for Green Organic Syntheses Using Heterogeneous Metal Catalysts
Authors: Kaneda Kiyotomi
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Norbornane/Ene and Heteronorbornane/Ene β‐Amino Acids
Authors: Csende Ferenc , Fulop Ferenc , Stajer Geza
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Calixcrowns : Synthesis and Properties
Authors: Salorinne Kirsi , Nissinen Maija
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Approaches to Antifungal Therapy for Invasive Mycoses
Authors: Mathew Bijoy P. , Nath Mahendra
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Beyond the Ugi Reaction: Less Conventional Interactions Between Isocyanides and Iminium Species
Authors: El Kaim Laurent , Grimaud Laurence
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Supramolecular Structures and Nanoassemblies of Tetrathiafulvalene Oligomers
Authors: Hasegawa Masashi , Enozawa Hideo , Iyoda Masahiko
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polymer‐Fullerene Bulk‐Heterojunction Solar Cells
Authors: Dennler Gilles , Scharber Markus C. , Brabec Christoph J.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Recognition of Neutral and Charged Guests Using Metallomacrocyclic Hosts
Authors: Korendovych Ivan V. , Roesner Rebecca A. , Rybak‐Akimova Elena V.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Isolation of a ventricle‐specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development
Authors: Park Jae‐Sun , Kim Hyung‐Seok , Kim Jun‐Dae , Seo Jungwon , Chung Kyung‐Sook , Lee Ho‐Sa , Huh Tae‐Lin , Jo Inho , Kim Yong‐Ou
Published: May 2009

We investigated chamber‐specific gene expression by isolating a 2.2‐kb polymerase chain reaction product containing the 5′‐flanking region of the zebrafish ventricular myosin heavy‐chain gene (vmhc). Promoter analysis revealed that the fragment, consisting of nucleotides from −301 to +26, is sufficient for vmhc promoter activity. Among several putative cis‐acting elements in the region, a GATA‐binding site was identified to be crucial for the activity of the promoter, as evidenced by the complete abolishment of promoter activity by a single nucleotide substitution of GATA‐binding site (−287, C→T). Knockdown of GATA‐binding proteins 4 and 6 (GATA4 and ‐6) by their antisense morpholino oligonucleotides resulted in reduced green fluorescent protein (GFP) reporter gene and endogenous vmhc expression. These findings suggest that GATA4 and ‐6 play a key role in the regulation of vmhc expression in the ventricle. In addition, the vmhc promoter and the transgenic zebrafish (vmhc:gfp) are useful tools to study the formation and function of the ventricle. Developmental Dynamics 238:1574–1581, 2009. © 2009 Wiley‐Liss, Inc.
Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus
Authors: Wheeler Grant N. , Brändli André W.
Published: May 2009

Chemical genetics uses small molecules to modulate protein function and, in principle, has the potential to perturb any biochemical event in a complex cellular context. The application of chemical genetics to dissect biological processes has become an attractive alternative to mutagenesis screens due to its technical simplicity, inexpensive reagents, and low‐startup costs. In vertebrates, only fish and amphibians are amenable to chemical genetic screens. Xenopus frogs share a long evolutionary history with mammals and so represent an excellent model to predict human biology. In this review, we discuss the lessons learned from chemical genetic studies carried out in zebrafish and Xenopus. We highlight how Xenopus can be employed as a convenient first‐line animal model at various stages of the drug discovery and development process and comment on how they represent much‐needed tools to bridge the gap between traditional in vitro and preclinical mammalian assays in biomedical research and drug development. Developmental Dynamics 238:1287–1308, 2009. © 2009 Wiley‐Liss, Inc.
Synthesis, Structures, and Photophysical Properties of Two Organostannoxanes from a Novel Acrylic Acid Derived from Phenothiazine
Authors: Li Dongmei , Hu Rentao , Zhou Wen , Sun Pingping , Kan Yuhe , Tian Yupeng , Zhou Hongping , Wu Jieying , Tao Xutang , Jiang Minhua
Published: May 2009

(E)‐3‐(10‐ethylphenothiazine‐3‐yl)acrylic acid (LCOOH) was synthesized. LCOOH reacted with Ph3Sn(OH) and nBu2SnO to afford Ph3SnO2CL (1) and {[nBu2SnO2CL]2O}2 (2), respectively. The structures of all the compounds were solved by single‐crystal X‐ray diffraction. Compounds 1 and 2 present discrete and ladder frameworks, respectively. The one‐photon absorption and excited fluorescence, and two‐photon excited fluorescence spectra of all the compounds were systematically investigated. The results show that the two organostannoxanes exhibit much more enhanced two‐photon absorption properties than LCOOH. TDDFT computational studies have been performed to elucidate the electronic structures of the ground state of LCOOH.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Substitution of trans fatty acids in foods on the Danish market
Authors: Bysted Anette , Mikkelsen Aase Ærendahl , Leth Torben
Published: May 2009

Three surveys of the content of trans fatty acids (TFA) in foods on the Danish market were carried out before and after the Danish regulation was introduced in January 2004 restricting the use of industrially produced (IP)‐TFA to a maximum of 2 g per 100 g fat in any food product. For this purpose, food samples were collected in 2002–3, 2004–5, and 2006–7. Of these, 60 paired samples (defined as samples included in two of the three investigations and with higher levels of IP‐TFA in the first determination than in the second) were identified. Comparisons of the fatty acid profiles showed that, in 68% of the products (e.g. sweets, cakes and cookies as well as fast food such as pie and tortilla), IP‐TFA were mainly substituted with saturated fatty acids (SFA). In some cases, the SFA source was coconut fat, whereas in other products, palm oil was added instead of partially hydrogenated oils. However, in important cases like frying fats, healthier fat substitutes with monounsaturated fatty acids were used. The surveys showed that the IP‐TFA content has been reduced or removed from most products with originally high IP‐TFA content, like French fries, microwave oven popcorn and various bakery products, so that IP‐TFA are now insignificant for the intake of TFA in Denmark.
Polyarylated Thiazoles via a Combined Halogen Dance – Cross‐Coupling Strategy
Authors: Schnürch Michael , Khan Ather Farooq , Mihovilovic Marko D. , Stanetty Peter
Published: May 2009

The application of the halogen dance reaction for the synthesis of starting materials for cross‐coupling reactions is reported. The obtained compounds were then successfully applied in sequential Stille and Suzuki–Miyaura cross‐coupling reactions to obtain novel thiazole derivatives. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Boradipyrromethenecyanines
Authors: Yakubovskyi Viktor P. , Shandura Mykola P. , Kovtun Yuriy P.
Published: May 2009

A series of meso‐polymethine‐substituted BODIPY compounds have been synthesized by the reaction of meso‐methyl‐3,5‐diphenylboradipyrromethene with a number of hemicyanine derivatives. The dyes obtained exhibit intense long‐wavelength absorption, but weak fluorescence. Upon protonation of the dyes the long‐wavelength band disappears and the intensity of the short‐wavelength band increases significantly. It has been shown that the properties of the dyes obtained, which we call boradipyrromethenecyanines, are closely related to those of merocyanine dyes rather than those of boron dipyrromethenes.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Nickel‐Catalyzed Asymmetric Hydrovinylation Using Lewis Acid Activation
Authors: Lassauque Nicolas , Franciò Giancarlo , Leitner Walter
Published: May 2009

A broad range of commercially available Lewis acids were investigated for their ability to activate and regulate nickel catalysts for asymmetric hydrovinylation processes using styrene as model substrate and ligand (Ra,SC,SC)‐5as benchmark system. The colour change during the activation step associated with the halide abstraction furnishes helpful indications to adapt the activation conditions to the pre‐catalyst/Lewis acid system. In general, metal halide Lewis acids led to higher activities and enantioselectivities than the corresponding triflates. In particular, the use of InI3as co‐catalyst resulted in the same chemo‐ and enantioselectivity and even higher activity than the benchmark system based onNaBArF. Moreover, InI3is safe to handle and cheap, thus providing a simple and practical protocol for an efficient hydrovinylation reaction.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Palladium‐Catalyzed Intramolecular Selenocarbamoylation of Allenes with Carbamoselenoates: A New Entry to α,β‐Unsaturated Lactams
Authors: Toyofuku Masashi , Murase Erika , Nagai Hiroyuki , Fujiwara Shin‐ichi , Shin‐ike Tsutomu , Kuniyasu Hitoshi , Kambe Nobuaki
Published: May 2009

Pd(PPh3)4‐catalyzed intramolecular selenocarbamoylation of allenes led to the regioselective formation of α,β‐unsaturated five‐ and six‐membered lactams having an allyl selenide unit. This procedure could be applied to the synthesis of the corresponding sulfur analogue by thiocarbamoylation as well as a cyclopentenone. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
A new CE‐ESI‐MS method for the detection of stable hemoglobin acetaldehyde adducts, potential biomarkers of alcohol abuse
Authors: De Benedetto Giuseppe E. , Fanigliulo Matteo
Published: May 2009

A new CE‐ESI‐MS method was developed to provide a simple way to study changes to hemoglobin (HbA) induced by acetaldehyde (Ach) in vitro. Instrumental parameters were univariately optimized in order to maximize the sensitivity of the CE‐ESI‐MS method. The electrophoretic separations were carried out in poly‐E323‐coated capillaries using 60 mM formic acid raised to pH 3.0 with ammonia and containing 5% 2‐propanol while the sheath liquid, 2‐propanol/water (30:70) with 0.1% formic acid, was delivered at 1.0 μL/min through a coaxial sheath flow electrospray interface. The HbA was incubated with Ach for intervals up to 24 h at concentration varying in the window 0.2–20 mM. Four stable Ach‐hemoglobin adducts in the hemoglobin tryptic digest were observed at the submillimolar Ach concentration and characterized by MS/MS experiments: although the α and β N‐amino terminal modifications were expected, the two internal ones arising, respectively, from the condensation of Ach molecules on the histidine residue in position 4 in α4 (i.e. the fourth peptide after tryptic digestion of alpha chain starting from amino terminal) and on the asparagine residue in position 2 in β3, were identified for the first time. During the in vitro experiments higher concentrations of Ach were also used; however, it was not possible to identify any other stable modification of hemoglobin. Interestingly, those stable modifications are the only ones in vivo identified in the hemoglobin of moderate alcohol drinkers.
Direct determination of plutonium(V) and neptunium(V) complexation by carbonate ligand with CE‐ICP‐sector field MS
Authors: Topin Sylvain , Aupiais Jean , Moisy Philippe
Published: May 2009

Direct determination of the stability constants of some pentavalent actinides (Np and Pu) with carbonate ligands was investigated by CE‐ICP‐sector field MS (SFMS). The high sensitivity of ICP‐SFMS coupled with the high separation power of CE makes it possible to determine the mobility of each species as well as the stability constants with good accuracy. A procedure for preparing pentavalent plutonium at trace level has been successfully tested enabling the study of Pu(V) complexation by CE‐ICP‐SFMS. Stability constants β1, β2 and β3 have been obtained at 25±1°C at a constant ionic strength of 0.37 M in NaClO4 for K1 and NaCl for β2 and β3. The results were extrapolated to zero ionic strength and compared with data available in the literature for Np(V). The following stability constants were obtained for a Pu(V)/CO3 system: