bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Wide Analysis of Odorant-Binding Proteins and Chemosensory Proteins in the Bean bug Riptortus pedestris
Authors: Li Jin-Bu , Yin Mao-Zhu , Yao Wei-Chen , Ma Sai , Dewer Youssef , Liu Xing-Zhou , Wang Yue-Ying , Wang Chao-Wei , Li Bao-Ping , Zhu Xiu-Yun
Published: July 2022

Insects have sensitive olfactory systems to interact with environment and respond to the change in host plant conditions. Key genes in the system can be potential targets for developing new and efficient pest behaviour control methods. Riptortus pedestris is an important soybean pest in East Asia and has caused serious damage to the soybean plants in Huang-Huai-Hai region of China. However, the current treatment of pests is dominated by chemical insecticides and lacks efficient sustainable prevention and control technologies. In this study, we identified 49 putative odorant-binding proteins (OBPs) (43 were new genes) and 25 chemosensory proteins (CSPs) (17 were new genes) in R. pedestris genome. These OBP and CSP genes are clustered in highly conserved groups from other hemipteran species in phylogenetic trees. Most RpedOBPs displayed antennal-biased expression. Among the 49 RpedOBPs, 33 were significantly highly expressed in the antennae, including three male-biased and nine female-biased. While many RpedCSPs were detected both in the antennae and in non-antennal tissues, only 11 RpedCSPs displayed antennal-biased expression, in which four RpedCSPs were male-biased and five RpedCSPs were female-biased. Some OBP and CSP genes showed sex-biased expression profiles. Our results not only provide a foundation for future exploration of the functions of RpedOBPs and RpedCSPs but also aid in developing environmentally friendly insecticides in the future.
Belowground Root Competition Alters the Grass Seedling Establishment Response to Light by a Nitrogen Addition and Mowing Experiment in a Temperate Steppe
Authors: Zhong Mingxing , Liu Chun , Wang Xiukang , Hu Wei , Qiao Ning , Song Hongquan , Chen Ji , Miao Yuan , Wang Gang , Wang Dong , Yang Zhongling
Published: July 2022

Predicting species responses to climate change and land use practices requires understanding both the direct effects of environmental factors as well as the indirect effects mediated by changes in belowground and aboveground competition. Belowground root competition from surrounding vegetation and aboveground light competition are two important factors affecting seedling establishment. However, few studies have jointly examined the effect of belowground root and light competition on seedling establishment, especially under long-term nitrogen addition and mowing. Here, we examined how belowground root competition from surrounding vegetation and aboveground light competition affect seedling establishment within a long-term nitrogen addition and mowing experiment. Seedlings of two grasses (Stipa krylovii and Cleistogenes squarrosa) were grown with and without belowground root competition under control, nitrogen addition, and mowing treatments, and their growth characteristics were monitored. The seedlings of the two grasses achieved higher total biomass, height, mean shoot and root mass, but a lower root/shoot ratio in the absence than in the presence of belowground root competition. Nitrogen addition significantly decreased shoot biomass, root biomass, and the survival of the two grasses. Regression analyses revealed that the biomass of the two grass was strongly negatively correlated with net primary productivity under belowground root competition, but with the intercept photosynthetic active radiation in the absence of belowground root competition. This experiment demonstrates that belowground root competition can alter the grass seedling establishment response to light in a long-term nitrogen addition and mowing experiment.
Exogenously Applied Proline Enhances Morph-Physiological Responses and Yield of Drought-Stressed Maize Plants Grown Under Different Irrigation Systems
Authors: Ibrahim Abd El-Aty , Abd El Mageed Taia , Abohamid Yasmin , Abdallah Hanan , El-Saadony Mohamed , AbuQamar Synan , El-Tarabily Khaled , Abdou Nasr
Published: July 2022

The exogenous application of osmoprotectants [e.g., proline (Pro)] is an important approach for alleviating the adverse effects of abiotic stresses on plants. Field trials were conducted during the summers of 2017 and 2018 to determine the effects of deficit irrigation and exogenous application of Pro on the productivity, morph-physiological responses, and yield of maize grown under two irrigation systems [surface irrigation (SI) and drip irrigation (DI)]. Three deficit irrigation levels (I100, I85, and I70, representing 100, 85, and 70% of crop evapotranspiration, respectively) and two concentrations of Pro (Pro1 = 2 mM and Pro2 = 4 mM) were used in this study. The plants exposed to drought stress showed a significant reduction in plant height, dry matter, leaf area, chlorophyll content [soil plant analysis development (SPAD)], quantum efficiency of photosystem II [Fv/Fm, Fv/F0, and performance index (PI)], water status [membrane stability index (MSI) and relative water content (RWC)], and grain yield. The DI system increased crop growth and yield and reduced the irrigation water input by 30% compared with the SI system. The growth, water status, and yield of plants significantly decreased with an increase in the water stress levels under the SI system. Under the irrigation systems tested in this study, Pro1 and Pro2 increased plant height by 16 and 18%, RWC by 7 and 10%, MSI by 6 and 12%, PI by 6 and 19%, chlorophyll fluorescence by 7 and 11%, relative chlorophyll content by 9 and 14%, and grain yield by 10 and 14%, respectively, compared with Pro0 control treatment (no Pro). The interaction of Pro2 at I100 irrigation level in DI resulted in the highest grain yield (8.42 t ha–1). However, under the DI or SI system, exogenously applied Pro2 at I85 irrigation level may be effective in achieving higher water productivity and yield without exerting any harmful effects on the growth or yield of maize under limited water conditions. Our results demonstrated the importance of the application of Pro as a tolerance inducer of drought stress in maize.
Soil Nitrogen Transformation Process Influenced by Litterfall Manipulation in Two Subtropical Forest Types
Authors: Yan Wende , Farooq Taimoor Hassan , Chen Yi , Wang Wancai , Shabbir Rubab , Kumar Uttam , Riaz Muhammad Umair , Alotaibi Saqer S. , Peng Yuanying , Chen Xiaoyong
Published: July 2022

Nitrogen (N) is often recognized as the primary limiting nutrient element for the growth and production of forests worldwide. Litterfall represents a significant pathway for returning nutrients from aboveground parts of trees to the soils and plays an essential role in N availability in different forest ecosystems. This study explores the N transformation processes under litterfall manipulation treatments in a Masson pine pure forest (MPPF), and Masson pine and Camphor tree mixed forest (MCMF) stands in subtropical southern China. The litterfall manipulation included litterfall addition (LA), litterfall removal (LR), and litterfall control (LC) treatments. The project aimed to examine how litterfall inputs affect the soil N process in different forest types in the study region. Results showed that soil ammonium N (NH4+-N) and nitrate N (NO3−-N) content increased under LA treatment and decreased under LR treatment compared to LC treatment. LA treatment significantly increased soil total inorganic N (TIN) content by 41.86 and 22.19% in MPPF and MCMF, respectively. In contrast, LR treatment decreased the TIN content by 10 and 24% in MPPF and MCMF compared to LC treatment. Overall, the soil net ammonification, nitrification, and N mineralization rates were higher in MCMF than in MPPF; however, values in both forests were not significantly different. LA treatment significantly increased annual net ammonification, nitrification, and mineralization in both forest types (p < 0.05) compared to LC treatment. LR treatment significantly decreased the values (p < 0.05), except for ammonification, where LR treatment did not differ substantially compared to LC treatment. Our results suggested that changes in litterfall inputs would significantly alter soil N dynamics in studied forests of sub-tropical region. Moreover, mixed forest stands have higher nutrient returns due to mixed litter and higher decomposition compared to pure forest stands.
Transcriptome and Metabolome Analyses Reveal the Involvement of Multiple Pathways in Flowering Intensity in Mango
Authors: Liang Qingzhi , Song Kanghua , Lu Mingsheng , Dai Tao , Yang Jie , Wan Jiaxin , Li Li , Chen Jingjing , Zhan Rulin , Wang Songbiao
Published: July 2022

Mango (Mangifera indica L.) is famous for its sweet flavor and aroma. China is one of the major mango-producing countries. Mango is known for variations in flowering intensity that impacts fruit yield and farmers' profitability. In the present study, transcriptome and metabolome analyses of three cultivars with different flowering intensities were performed to preliminarily elucidate their regulatory mechanisms. The transcriptome profiling identified 36,242 genes. The major observation was the differential expression patterns of 334 flowering-related genes among the three mango varieties. The metabolome profiling detected 1,023 metabolites that were grouped into 11 compound classes. Our results show that the interplay of the FLOWERING LOCUS T and CONSTANS together with their upstream/downstream regulators/repressors modulate flowering robustness. We found that both gibberellins and auxins are associated with the flowering intensities of studied mango varieties. Finally, we discuss the roles of sugar biosynthesis and ambient temperature pathways in mango flowering. Overall, this study presents multiple pathways that can be manipulated in mango trees regarding flowering robustness.
Adaptation and Validation of a Test for the Evaluation of Tactical Knowledge in Soccer: Test de Conocimiento Táctico Ofensivo en Fútbol for the Brazilian Context (TCTOF-BRA)
Authors: Rechenchosky Leandro , Menegassi Vanessa Menezes , Jaime Matheus de Oliveira , Borges Paulo Henrique , Serra-Olivares Jaime , Rinaldi Wilson
Published: July 2022

Background

Studies and tests to assess the tactical domain of young soccer players are recent, and few instruments meet the majority of quality criteria.

Objective

To adapt and validate theTest de Conocimiento Táctico Ofensivo en Fútbol(TCTOF) for the Brazilian context (TCTOF-BRA).

Methods

The article consists of two studies. Study 1 (n = 111) included the translation, theoretical/semantic analysis, back translation, cross-cultural equivalence, and content and face validity (pre-test). In study 2 (n = 768), a theoretical and empirical item analysis was carried out, followed by construct validity [exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and the known-groups method] and reliability (internal consistency and repeatability).

Results

In the cross-cultural evaluation, the Coefficient of content validity total (CCVt) of the instrument was 0.96 and in the content validity, the CCVtof the instrument was 0.87. The face validity was confirmed (>95%). After theoretical and empirical analysis, 15 questions were included in theTeste de Conhecimento Tático Ofensivo no Futebol(TCTOF-BRA). The EFA showed a model with adequate fit (KMO = 0.69;Bartlett p < 0.001), with a factor structure considered very good, composed of four factors (decision making, operational tactical principles, collective tactical-technical elements, and rules). The CFA by the Asymptotically Distribution-Free estimation method demonstrated good and very good goodness of fit indices (X2/df = 1.54, GFI = 0.99, CFI = 0.94, TLI = 0.92, PGFI = 0.71, PCFI = 0.76, RMSEA = 0.03, and ECVI = 0.26). The known-groups method showed significant differences (p < 0.01) and effect sizes varying from small-to-medium to large. With respect to reliability, coefficients of 0.89 (CR) and 0.74 (KR20) for internal consistency and 0.85 for repeatability were found.

Conclusion

The TCTOF-BRA presented satisfactory evidence, demonstrating it to be an instrument with valid and reliable measures for the evaluation of tactical knowledge (declarative and theoretical procedural), based on specific knowledge and decision making (cognitive domain), of Brazilian young soccer players from 12 to 17.9 years old.
Evaluating the Efficacy of Ethical Guidelines for Online Screening of Mental Health in South Africa
Authors: Hassem Tasneem , Laher Sumaya
Published: July 2022

Despite the rapid growth in digital mental health options, a systematic review conducted on the ethics of developing online mental health screening instruments highlighted that there were no formal guidelines in this area. This lack of formal guidelines and the results of the systematic review led to the development of formal guidelines for online mental health screening tools in South Africa. This study aimed to explore the efficacy of these draft guidelines using a qualitative design with two samples of individuals recognised as experts in the field of mental health. Sample one consisted of a purposive sample of 15 experts who commented on the appropriateness of the draft guidelines. The second sample consisted of 9 experts who completed the Appraisal of Guidelines for Research and Evaluation (AGREE) instrument to assess the guidelines. Both samples were in agreement on the relevance of the core content areas in the guidelines, namely purpose and scope, modes of testing, psychometric properties, informed consent, ensuring minimal risk to participants, feedback as well as data security. There was also agreement on the appropriateness of the methods used to develop the guidelines. The use of the guidelines was supported with the suggestion that issues of risk and suicidality be explored further.
The Role of Denial in Vaccine Skeptics and “Anti-vax” Blame: A Psychodynamic Approach
Authors: Putois Olivier , Helms Julie
Published: July 2022

In this paper, we propose to account for the blame addressed to vaccine skeptics and “anti-vax” (VS and AV) by considering their attitude as the result of the psychological mechanism of denial, understood in a psychodynamic manner. To that effect, we draw on a secondary account of our clinical experience in two hospital units (psychiatry and intensive care unit), and on openly available media material. First, we lay out how VS and AV can be understood as the result from fetishist risk denial, a specific psychological transaction with an object by which VS and AV people feel intimately protected; this object is viewed as so powerful that its protection makes the vaccine appear irrelevant. Second, we show how this mechanism can explain the specific content of the blame frequently addressed to VS and AV, who are reproached with being selfish by vaccinated people and caregivers. We contend that, contrary to common belief, they are thus blamed because they force others (and especially caregivers) to compensate their lack of self-protection and preservation, which derives from their exclusive relation to an almighty object. While such a relation accounts for the unwillingness to consider vaccination, it also explains the harshness of the blame voiced by caregivers, who feel helpless in most situations as they cannot effectively force VS and AV to take care of themselves and others.
Prevalence and Associated Family Factors of Sibling Bullying Among Chinese Children and Adolescents
Authors: Qing Zaihua , Ma Yankun , Liu Xiaoqun
Published: July 2022

Sibling bullying is the most common form of aggression within family worldwide, while the prevalence and correlations of sibling bullying is little known in China. The current research focused on the association between family factors and sibling bullying among Chinese adolescents, and explore sex differences in sibling bullying in the context of Chinese culture. A cross-sectional study was conducted to explore the characteristics of sibling bullying by sampling 6302 children and adolescents who had at least 1 sibling living in the household. Of the participants, 1827 (29.0%) were involved in sibling bullying over the past half year, and pure victims, pure bullies, and bully-victims were 486 (7.7%), 510 (8.1%), and 831 (13.2%), respectively. Family factors of sibling bullying were partly different between boys and girls. Parental absence of both father and mother was a risk factor of being a pure bully and a bully-victim for boys, and of being a pure victim for girls. Parental son preference increased the odds of being a pure victim and a bully-victim for boys, and of being all roles of sibling bullying involvement for girls. Besides, parent–parent violence, parent–child violence, and living with a single parent were risk factors of sibling bullying. The results underline the importance of home environment on sibling relationship, and intervention of sibling bullying should include improving family climate.
Which Cognitive Factors Predict L2 Grammar Learning: Cognitive Control, Statistical Learning, Working Memory, or Attention?
Authors: Chen Yao , Li Li , Wang Mengxing , Wang Ruiming
Published: July 2022

Individual variability of cognitive factors in second language (L2) grammar learning has long been the focus in the field of L2 acquisition. Most explored the issue by focusing on one factor like cognitive control, working memory, statistical learning (SL), or attention. Few investigated the topic by taking all these factors into consideration. However, different factors might interact and collaboratively contribute to the learning process. Examining the issue by considering all the factors might yield different results and facilitate our understanding of the mechanism subserving L2 grammar learning. Therefore, this study explored whether and how these factors predicted L2 grammar learning. A total of 34 college students completed a set of cognitive measurements on these cognitive factors, after which they were trained with artificial grammar over 5 consecutive days. Using multiple regression analysis and machine learning algorithms, we found that in the initial phase, SL was the more significant predictor, whereas in the intermediate and the last phases, cognitive control served as the more significant predictor. In other words, in the initial phase of L2 grammar learning, SL might play an important role, whereas in the intermediate and proficient phase, the updating component of cognitive control might play a more significant role. The findings provided empirical evidence to the neurocognitive account of grammar learning, shedding light on the mechanism of L2 grammar learning.
Propofol Versus Sevoflurane General Anaesthesia for Selective Impairment of Attention Networks After Gynaecological Surgery in Middle-Aged Women: A Randomised Controlled Trial
Authors: Chen Chen , Wang Yuxue , Rao Jin , Tang Weixiang , Wu Weiwei , Li Yuanhai , Xu Guanghong , Zhong Weiwei
Published: July 2022

Purpose

Attention is an essential component of cognitive function that may be impaired after surgery with anaesthesia. Propofol intravenous anaesthesia and sevoflurane inhalational anaesthesia are frequently used in gynaecological surgery. However, which type of anaesthetic has fewer cognitive effects postoperatively remains unclear. We compared the differences in attention network impairment after surgery in women receiving propofol versus sevoflurane general anaesthesia.

Patients and Methods

Eighty-three patients with gynaecological diseases who were 40–60 years of age were involved in the study. All patients underwent elective gynaecological surgery under either total intravenous anaesthesia or sevoflurane inhalational anaesthesia, depending on randomisation. The efficiencies of the three attention networks were captured using the attention network test preoperatively and on the 1st and 5th postoperative days.

Results

Both groups of patients showed differences in impairments on the 1st and 5th postoperative days. Pairwise comparisons indicated that the alerting and orienting networks of patients in the propofol group were impaired to a greater extent than those of patients in the sevoflurane group on the 1st postoperative day, while the executive control network was impaired to a lesser extent. On the 5th postoperative day, the alerting networks of both groups recovered to the baseline level. Patients in the propofol group still showed impairment of the orienting network, while patients in the sevoflurane group recovered to baseline. For the executive control network, patients in the sevoflurane group still exhibited more severe impairment than those in the propofol group.

Conclusion

In middle-aged women, propofol impaired orienting and alerting networks more than sevoflurane, while sevoflurane showed more residual impairment of the executive control network.
Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents
Authors: Jiang Yuanliang , Qin Mengchang , Teng Teng , Li Xuemei , Yu Ying , Wang Jie , Wu Hongyan , He Yuqian , Zhou Xinyu , Xie Peng
Published: July 2022

Background

Children and adolescents are at a high risk of major depressive disorder (MDD) with known sex differences in epidemiology. However, there are currently no objective laboratory-based sex-specific biomarkers available to support the diagnoses of male and female patients with MDD.

Methods

Here, a male set of 42 cases and 27 healthy controls (HCs) and a female set of 42 cases and 22 HCs were recruited. This study investigated the sex differences of plasma metabolite biomarkers in young patients with MDD by the application of ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry.

Results

The metabolic profiles showed clear separations in both male and female sets. In total, this study identified 57 male-related and 53 female-related differential metabolites. Compared with HCs, both male and female subjects with MDD displayed four significantly altered pathways. Notably, biliverdin was selected as an independent diagnostic male-specific biomarker with an area under the receiver operating characteristic curve of 0.966, and phosphatidylcholine (10:0/14:1) was selected as a female-specific biomarker, achieving an area under the curve (AUC) of 0.957.

Conclusion

This metabolomics study may aid in the development of a plasma-based test for the diagnosis of male and female children and adolescents with MDD, as well as give new insight into the pathophysiology of sex differences in children and adolescents with MDD.
Top 100 Cited Papers on Premenstrual Syndrome/Premenstrual Dysphoric Disorder: A Bibliometric Study
Authors: Gao Mingzhou , Zhang Hao , Wang Changlin , Mou Xiangyu , Zhu Qingjun , Wang Jieqiong , Gao Dongmei
Published: July 2022

Background

Premenstrual syndrome/premenstrual dysphoric disorder is a serious condition affecting women worldwide, causing clinically significant distress or interference. Therefore, solving these diseases has become the utmost concern worldwide, culminating in numerous studies. In this study, we performed bibliometric analysis on the 100 most cited papers with the aim of identifying research hot spots and trends in this field.

Methods

We screened the Science Citation Index Expanded (SCIE) of Web of Science (WOS) to identify the top 100 cited studies on PMS/PMDD. Next, we analyzed relevant literature from various journals, countries/regions, institutions, authors, and keywords. Finally, we used VOSviewer and Citespace software to generate knowledge maps and identify hot spots and trends.

Results

The top 100 highly cited studies were published in 55 journals, between 1999 and 2017, across 24 countries/regions around the world. Most articles were published in Obstetrics and Gynecology, whereas Psych neuroendocrinology had the largest average number of citations per paper. The United States had the highest number of publications, followed by England, Canada, and Sweden. The top three institutions that published the highly cited literature were the University of Pennsylvania, Yale University, and National Institute of Mental Health (NIMH). Obstetrics, Gynecology, Psychiatry, and Reproductive Biology were the main research directions, whereas the top 10 Co-occurrence of Keywords included double-blind, fluoxetine, efficacy, prevalence, epidemiology, phase sertraline treatment, depression, progesterone, placebo, and placebo-controlled trial. Results from cluster analysis indicated that more comprehensive epidemiology and steroid pathogenesis have gradually become the hot spots and trends.

Conclusion

These findings demonstrated that bibliometric analysis can intuitively and rapidly reveal the frontiers and hot spots of research in PMS/PMDD. Notably, epidemiology, steroid pathogenesis, GABAA receptor delta subunits, and double-blind placebo-controlled trials are potential areas of focus for future research.
Perceived Social Support and Associated Factors Among Community-Dwelling Older Adults With Frailty and Pre-frailty in Hangzhou, China
Authors: Fang Juan , Ren Jianping , Ren Lixian , Qiu Xiantao , Yuan Shuang , Wang Wenting , Wang Jinjing
Published: July 2022

Objectives:

The present study aimed to explore the social support among community-dwelling older adults with frailty and pre-frailty and to ascertain associated factors.

Methods

The frailty status of the participant was assessed via the Chinese FRAIL Scale. The dependent variable, level of social support, was evaluated using the Social Support Rating Scale (range: 12–66). This study explored the influencing factors from three aspects containing sociodemographic characteristics, family environment, and community environment. Independent-sample t-test, Analysis of Variance, and multiple linear regression analyses were conducted to examine determinants of social support.

Results

There were significant differences in overall social support between non-frail, pre-frail, and frail participants [38.01 (SD = 6.48) vs. 33.62 (SD = 6.25) vs. 30.50 (SD = 6.68), F = 62.157, p < 0.001]. Older adults with frailty and pre-frailty who were single would have lower levels of overall social support. In the pre-frail group, living alone was associated with lower overall social support. In contrast, the relationship with children and the availability of recreational activities were associated factors for the frail group.

Conclusions

The level of social support among frail and pre-frail community-dwelling older adults was lower than the robust older adults and influenced by different factors according to the frailty category, which suggests taking targeted measures for social support improvement.
Effectiveness of Early Warning Scores for Early Severity Assessment in Outpatient Emergency Care: A Systematic Review
Authors: Burgos-Esteban Amaya , Gea-Caballero Vicente , Marín-Maicas Patricia , Santillán-García Azucena , Cordón-Hurtado María de Valvanera , Marqués-Sule Elena , Giménez-Luzuriaga Marta , Juárez-Vela Raúl , Sanchez-Gonzalez Juan Luis , García-Criado Jorge , Santolalla-Arnedo Iván
Published: July 2022

Background and Objectives

Patient assessment and possible deterioration prediction are a healthcare priority. Increasing demand for outpatient emergency care services requires the implementation of simple, quick, and effective systems of patient evaluation and stratification. The purpose of this review is to identify the most effective Early Warning Score (EWS) for the early detection of the risk of complications when screening emergency outpatients for a potentially serious condition.

Materials and Methods

Systematic review of the bibliography made in 2022. Scientific articles in Spanish and English were collected from the databases and search engines of Pubmed, Cochrane, and Dialnet, which were published between 2017 and 2021 about EWSs and their capacity to predict complications.

Results

For analysis eleven articles were selected. Eight dealt with the application of different early warning scores in outpatient situations, concluding that all the scoring systems they studied were applicable. Three evaluated the predictive ability of various scoring systems and found no significant differences in their results. The eight articles evaluated the suitability of NEWS/NEWS2 to outpatient conditions and concluded it was the most suitable in pre-hospital emergency settings.

Conclusions

The early warning scores that were studied can be applied at the pre-hospital level, as they can predict patient mortality in the short term (24 or 48 h) and support clinical patient evaluation and medical decision making. Among them, NEWS2 is the most suitable for screening potentially deteriorating medical emergency outpatients.
Barriers to Use Artificial Intelligence Methodologies in Health Technology Assessment in Central and East European Countries
Authors: Tachkov Konstantin , Zemplenyi Antal , Kamusheva Maria , Dimitrova Maria , Siirtola Pekka , Pontén Johan , Nemeth Bertalan , Kalo Zoltan , Petrova Guenka
Published: July 2022

The aim of this paper is to identify the barriers that are specifically relevant to the use of Artificial Intelligence (AI)-based evidence in Central and Eastern European (CEE) Health Technology Assessment (HTA) systems. The study relied on two main parallel sources to identify barriers to use AI methodologies in HTA in CEE, including a scoping literature review and iterative focus group meetings with HTx team members. Most of the other selected articles discussed AI from a clinical perspective (n = 25), and the rest are from regulatory perspective (n = 13), and transfer of knowledge point of view (n = 3). Clinical areas studied are quite diverse—from pediatric, diabetes, diagnostic radiology, gynecology, oncology, surgery, psychiatry, cardiology, infection diseases, and oncology. Out of all 38 articles, 25 (66%) describe the AI method and the rest are more focused on the utilization barriers of different health care services and programs. The potential barriers could be classified as data related, methodological, technological, regulatory and policy related, and human factor related. Some of the barriers are quite similar, especially concerning the technologies. Studies focusing on the AI usage for HTA decision making are scarce. AI and augmented decision making tools are a novel science, and we are in the process of adapting it to existing needs. HTA as a process requires multiple steps, multiple evaluations which rely on heterogenous data. Therefore, the observed range of barriers come as a no surprise, and experts in the field need to give their opinion on the most important barriers in order to develop recommendations to overcome them and to disseminate the practical application of these tools.
Access to Health Care for Migrants Along the Mexico-United States Border: Applying a Framework to Assess Barriers to Care in Mexico
Authors: Infante César , Vieitez-Martinez Isabel , Rodríguez-Chávez César , Nápoles Gustavo , Larrea-Schiavon Silvana , Bojorquez Ietza
Published: July 2022

Background

Migrants in Mexico are entitled to care at all levels, independently of their migration status. However, previous studies show that access to care is difficult for this population. As the movement of in-transit migrants and asylum seekers has been interrupted at the Mexico-United States border by migration policies such as the “Remain in Mexico” program, and by border closures due to the COVID-19 pandemic, the Mexican health system has the challenge of providing them with health care. Levesque et al.'s framework, according to which access occurs at the interface of health system characteristics and potential users' abilities to interact with it, is a useful theoretical tool to analyze the barriers faced by migrants.

Objective

The objective of this article is to analyze the barriers to access the public Mexican health system, encountered by migrants in cities in Mexican states at the Mexico-United States border during the COVID-19 pandemic.

Methods

Data came from a multiple case study of the response of migrant shelters to health care needs during the COVID-19 pandemic. The study consisted of a non-probability survey of migrants with a recent health need, and interviews with persons working in civil society organizations providing services to migrants, governmental actors involved in the response to migration, and academics with expertise in the subject. We analyzed the quantitative and qualitative results according to Levesque et al.'s framework.

Results

36/189 migrants surveyed had sought health care in a public service. The main limitations to access were in the availability and accommodation dimension (administrative barriers decreasing migrants' ability to reach the system), and the affordability dimension (out-of-pocket costs limiting migrants' ability to pay). Civil society organizations were a major source of social support, helping migrants overcome some of the barriers identified.

Conclusions

While Mexico's health regulations are inclusive of migrants, in practice there are major barriers to access public health services, which might inhibit migrants from seeking those services. In order to comply with its commitment to guarantee the right to health of all persons, the Mexican health authorities should address the implementation gap between an inclusive policy, and the barriers to access that still remain.
HIV-1 Drug Resistance Profiles of Low-Level Viremia Patients and Factors Associated With the Treatment Effect of ART-Treated Patients: A Cross-Sectional Study in Jiangsu, China
Authors: Yuan Defu , Zhou Ying , Shi Lingen , Liu Yangyang , Lu Jing , Chen Jianshuang , Fu Gengfeng , Wang Bei
Published: July 2022

Objectives

Evaluating the drug resistance (DR) profiles of LLV patients and the influencing factors of treatment effects in Jiangsu Province.

Method

The Pol gene (Reverse transcriptase and protease) was amplified and sequenced to identify the genotypes and DR profiles among LLV patients in 2021. Questionnaire survey was conducted among HIV/AIDS patients to investigate the potential influence factors of treatment effects.

Results

242 Pol genes were amplified from 345 specimens, and ten genotypes were detected. The DR rate was 40.5%, with 66, 86, and 14 being resistant to NRTIs, NNRTIs, and PIs, respectively. Patients treated with the 2NRTIs+PIs regimen were detected with more DR; and drug resistance was less detected in married or cohabiting patients than unmarried patients. Non-smokers were less likely to develop LLV at follow-up than smokers; patients with stage II clinical stage at diagnosis and using 2NRTIs+PIs regimen were also more likely to develop LLV at follow-up.

Conclusion

Drug resistance profiles in LLV patients are severe and differ in treatment regimens and marital statuses. Meanwhile, smoking history, clinical stage, and treatment regimen may influence the therapeutic effect. It is necessary to include LLV people in the free drug resistance testing program.
A Sustainability Planning Framework and Methods for Rural Drinking Water in Satara District, Maharashtra, India
Authors: Wescoat James L. , Murty Jonnalagadda V. R. , Singh Ranu , Verma Piyush
Published: July 2022

Districts across India are progressing toward the national Jal Jeevan Mission goal of piped water supply and 100% Functional Household Tap Connections (FHTC) for all by 2024. While state and national data monitor progress toward tap water connection coverage, the functionality and sustainability of those piped water supplies are less clear. This study presents a Sustainability Planning Framework to assess rural drinking water conditions and needs at the village, block, and district scales. It employs a mobile app to survey five key aspects of sustainability: source water sustainability, water service sustainability, operations and maintenance financial sustainability, village institutional capacity, and asset management. Ordinal scores for these sustainability variables are analyzed and interpreted though GIS mapping to identify locations and types of village support needed. Scores are aggregated to create an overall village drinking water sustainability index. Important hydroclimatic, geomorphological, and socio-economic correlates of the drinking water sustainability index are also examined. This framework and methods can help districts in Maharashtra and other states analyze drinking water services, plan future investments, and make policy adjustments to ensure sustainability.
Bouncing Back: Coping After Being Cut From A Team
Authors: Neely Kacey C.
Published: July 2022

Each new season, youth athletes show up to team tryouts in hopes of making the team. However, there are only so many spots on the roster, and sometimes athletes get cut. Deselection, or getting cut, is the elimination of an athlete from a competitive sport team based on a coach’s decision. Deselection is an aspect of competitive sport that many youth athletes experience, and it can result in negative psychological, social and emotional consequences such as a lost sense of self, loss of friendships, and feelings of anxiety, embarrassment, and sadness. This article presents a study looking at how athletes (and their parents) coped with deselection from sport teams. The results explain some of the coping strategies youth athletes and their parents used together and how athletes can bounce back after getting cut.
Sensitive Measures of Soil Health Reveal Carbon Stability Across a Management Intensity and Plant Biodiversity Gradient
Authors: Martin Tvisha , Sprunger Christine D.
Published: July 2022

Soil carbon (C) is a major driver of soil health, yet little is known regarding how sensitive measures of soil C shift temporally within a single growing season in response to short-term weather perturbations. Our study aimed to i) Examine how long-term management impacts soil C cycling and stability across a management intensity and plant biodiversity gradient and ii) Assess how sensitive soil health indicators change temporally over the course of a single growing season in response to recent weather patterns. Here we quantify a variety of sensitive soil C measures at four time points across the 2021 growing season at the W.K. Kellogg Biological Station’s Long Term Ecological Research Trial (LTER) located in southwest Michigan, USA. The eight systems sampled included four annual soybean (Glycine max) systems that ranged in management intensity (conventional, no-till, reduced input, and biologically-based), two perennial biofuel cropping systems (switchgrass (Panicum virgatum) and hybrid poplars (Populus nigra x P.maximowiczii)), and two unmanaged systems (early successional system and a mown but never tilled grassland). We found that unmanaged systems with increased perenniality enhanced mineralizable C (Min C) and permanganate oxidizable C (POXC) values. Additionally, all soil health indicators were found to be sensitive to changes in short-term weather perturbations over the course of the growing season. The implications of this study are threefold. First, this study assess indicators of labile and stable C pools over the course of the growing season and reflects the stability of soil C in different systems. Second, POXC, Min C, and ß-glucosidase (GLU) activity are sensitive soil health indicators that fluctuate temporally, which means that these soil health indicators could help elucidate the impact that weather patterns have on soil C dynamics. Lastly, for effective monitoring of soil C, sampling time and frequency should be considered for a comprehensive understanding of soil C cycling within a system.
An Investigation of Bilateral Symmetry in Softball Pitchers According to Body Composition
Authors: Friesen Kenzie B. , Lang Angelica E. , Chad Karen E. , Oliver Gretchen D.
Published: July 2022

Introduction

High body fat percentage (bf%) is considered a potential injury risk factor for softball pitchers amidst the already high rates of pitching-related injury. Similarly, research points out that large bilateral asymmetries are another risk factor for softball pitchers. As softball pitching is a highly asymmetric sport and the repetitive nature of the windmill pitch places high stress on the body while pitchers are in unbalanced and asymmetric positions, research examining body composition and asymmetry is necessary.

Purpose

The purpose of this study was to compare functional characteristics of softball pitchers with a healthy and a high bf%. Bilateral symmetry was assessed for pitchers' hip and shoulder isometric strength (ISO) and range of motion (ROM) between the following two groups of softball pitchers: (1) those with a high bf% (≥32%) and (2) those with a healthy bf% (<32%).

Methods

A total of 41 high school female softball pitchers from the southern United States agreed to participate (1.69 ± 0.07 m, 76.14 ± 17.08 kg, 15.1 ± 1.1 years). Pitchers completed a dual-energy X-ray absorptiometry (DEXA) scan and were grouped into one of the following two categories based on their bf%: healthy (<32 bf%) and high (≥32 bf%). Bilateral symmetry was assessed for pitchers' hip and shoulder ISO and ROM using a handheld dynamometer and inclinometer, respectively. Bilateral arm bone and lean mass was also measured via the DEXA.

Results

Mixed analyses of variance revealed a significant interaction between bf% groups and side dominance for internal rotation shoulder ROM, F(1, 39) = 14.383, p < 0.001, η2p = 0.269. Main effects for side dominance were also observed for shoulder external rotation ISO, F(1, 39) = 8.133, p = 0.007, η2p = 0.173, hip internal rotation ISO, F(1, 39) = 4.635, p = 0.038, η2p = 0.106, arm bone mass, F(1, 39) = 38.620, p < 0.001, η2p = 0.498, and arm lean mass, F(1, 39) = 101.869, p < 0.001, η2p = 0.723.

Conclusion

Asymmetries and slight differences in functional characteristics exist between bf% groups. Altered functional characteristics may influence pitchers' windmill pitch movement and should be acknowledged by support staff to improve softball pitchers' health and longevity.

Implications

Insight into asymmetries can help researchers and clinicians understand the implication of excess body fat and further theorize mechanisms of injury among this athlete population.
Monitoring Variables Influence on Random Forest Models to Forecast Injuries in Short-Track Speed Skating
Authors: Briand Jérémy , Deguire Simon , Gaudet Sylvain , Bieuzen François
Published: July 2022

Injuries limit the athletes' ability to participate fully in their training and competitive process. They are detrimental to performance, affecting the athletes psychologically while limiting physiological adaptations and long-term development. This study aims to present a framework for developing random forest classifier models, forecasting injuries in the upcoming 1 to 7 days, to assist the performance support staff in reducing injuries and maximizing performance within the Canadian National Female Short-Track Speed Skating Program. Forty different variables monitored daily over two seasons (2018–2019 and 2019–2020) were used to develop two sets of forecasting models. One includes only training load variables (TL), and a second (ALL) combines a wide array of monitored variables (neuromuscular function, heart rate variability, training load, psychological wellbeing, past injury type, and location). The sensitivity (ALL: 0.35 ± 0.19, TL: 0.23 ± 0.03), specificity (ALL: 0.81 ± 0.05, TL: 0.74 ± 0.03) and Matthews Correlation Coefficients (MCC) (ALL: 0.13 ± 0.05, TL: −0.02 ± 0.02) were computed. Paired T-test on the MCC revealed statistically significant (p < 0.01) and large positive effects (Cohen d > 1) for the ALL forecasting models' MCC over every forecasting window (1 to 7 days). These models were highly determined by the athletes' training completion, lower limb and trunk/lumbar injury history, as well as sFatigue, a training load marker. The TL forecasting models' MCC suggests they do not bring any added value to forecast injuries. Combining a wide array of monitored variables and quantifying the injury etiology conceptual components significantly improve the injury forecasting performance of random forest models. The ALL forecasting models' performances are promising, especially on one time windows of one or two days, with sensitivities and specificities being respectively above 0.5 and 0.7. They could add value to the decision-making process for the support staff in order to assist the Canadian National Female Team Short-Track Speed Skating program in reducing the number of incomplete training days, which could potentially increase performance. On longer forecasting time windows, ALL forecasting models' sensitivity and MCC decrease gradually. Further work is needed to determine if such models could be useful for forecasting injuries over three days or longer.
Untangling the Physio-Chemical and Transcriptional Changes of Black Gram Cultivars After Infection With Urdbean Leaf Crinkle Virus
Authors: Karthikeyan Adhimoolam , Akilan Manoharan , Samyuktha Santhi Mathavan , Ariharasutharsan Gunasekaran , Shobhana V. G. , Veni Kannan , Tamilzharasi Murugesan , Keerthivarman Krishnan , Sudha Manickam , Pandiyan Muthaiyan , Senthil Natesan
Published: July 2022

Black gram (Vigna mungo) is an important pulse crop of India. The leaf crinkle disease caused by the urdbean leaf crinkle virus (ULCV) is a severe threat to black gram production. Black gram plants infected by ULCV show a considerable decline in plant growth and yield. However, detailed information about the interactions between the host, black gram, and ULCV is unclear. This study investigated the responses of two cultivars VBN (Bg) 6 and CO 5 to ULCV infection by physiological, biochemical, and transcriptional analyses. Virus symptoms were mild in VBN (Bg) 6 but were serious in CO 5. Upon the viral infection, VBN (Bg) 6 exhibited a low reduction in chlorophyll content than CO 5. The levels of sugar, protein, phenol, hydrogen peroxide (H2O2), and malondialdehyde (MDA) contents were altered by a viral infection in both cultivars. Although, the activities of antioxidant enzymes [Ascorbate peroxidase (APX), superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT)] were increased by ULCV infection. Following the viral infection, the expression level of the salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) defense pathway-related genes was recorded higher in the VBN (Bg) 6 than that recorded in CO 5, indicating a positive correlation between resistance and these indicative indices. This dynamic physio-biochemical and transcriptional profiles of two black gram cultivars on ULCV infection augment our understanding of the complex interaction response between this crop and its pathogen. Additionally, it offers an inventory of potential indicators for future black gram screening and breeding to enhance resistance.
Abscopal effect leading to complete disappearance of extensive meningiomatosis after gamma knife radiosurgery: Case report
Authors: Aldakhil Salman , Mathieu David
Published: July 2022

Background and Importance

The abscopal effect is partial or complete tumor response in a separate site that was not the target of prior local treatment. There have been only 50 well-documented cases from 1960 to 2014. Our case is the first one of presumed low-grade meningioma demonstrating a possible response via the abscopal effect after single-fraction stereotactic radiosurgery.

Clinical Presentation

A case of a 70-years-old female with extensive intracranial meningiomatosis who had complete disappearance of all tumors after gamma knife radiosurgery targeting the right petroclival part of the tumor. She had complete resolution of her symptoms, which included hearing loss, headache, ataxia and dysphagia.

Conclusion

The abscopal effect is an extremely rare phenomenon after local radiation therapy of a remote tumor. Our case demonstrates that this can occur in remote meningiomas after single fraction GKRS of a different tumor.