bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, for Control of Graves Hyperthyroidism—A Proof-of-Concept Trial
Authors: Kahaly George J , Stan Marius Nicolae , Frommer Lara , Gergely Peter , Colin Laurence , Amer Ahmed , Schuhmann Imelda , Espie Pascal , Rush James S , Basson Craig , He Yanling
Published: September 2019

Context

The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves disease (GD) by promoting autoreactive B-cell activation.

Objective

Evaluate efficacy and safety of a human, blocking, nondepleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD.

Design

Open-label, phase II proof-of-concept study.

Setting

Multicenter.

Patients

Fifteen with GD.

Intervention

Patients received 5 doses of iscalimab at 10 mg/kg intravenously over 12 weeks.

Main outcome measures

Thyroid-related hormones and autoantibodies, plasma soluble CD40, free CD40 on B cells, soluble CXCL13, pharmacokinetics, and safety were assessed.

Results

The iscalimab intervention resulted in complete CD40 engagement for up to 20 weeks. A clinical response and biochemical euthyroidism was observed in 7 of 15 (47%) patients. Free and total triiodothyronine and thyroxine normalized in 7 patients who did not receive any rescue medication with antithyroid drugs (ATD), and 2/15 (13.3%) showed normal thyrotropin. Six (40%) patients required ATD. Four of 7 responders relapsed after treatment completion. Serum concentrations of thyrotropin receptor autoantibodies (TSH-R-Ab) significantly declined in all patients (mean 15.3 IU/L vs 4.0 IU/L, 66% reduction; P < 0.001) and TSH-R-Ab levels normalized in 4 (27%). Thyroperoxidase and thyroglobulin autoantibodies significantly decreased in responders. Iscalimab rapidly reduced serum CXCL13 concentrations (P < 0.001). Twelve (80.0%) patients reported at least 1 adverse event (AE). All treatment-related AE were mild or moderate and resolved by end of the study.

Conclusion

Iscalimab was generally safe and clinically effective in a subgroup of hyperthyroid GD patients. The potential therapeutic benefit of iscalimab should be further tested.
Mitochondrial Dysfunction Induced by High Estradiol Concentrations in Endometrial Epithelial Cells
Authors: Chou Chia-Hung , Chen Shee-Uan , Chen Chin-Der , Shun Chia-Tung , Wen Wen-Fen , Tu Yi-An , Yang Jehn-Hsiahn
Published: September 2019

Context

A supraphysiological estradiol (E2) concentration after ovarian stimulation is known to result in lower embryo implantation rates in in vitro fertilization. Endometrial epithelial cell (EEC) apoptosis occurs after the stimulation with high E2 concentrations, and mitochondria play important roles in cell apoptosis.

Objective

To investigate the mitochondrial function in EECs after the stimulation with high E2 concentrations.

Materials and Methods

Human EECs were purified and cultured with different E2 concentrations (10-10, 10–9, 10–8, 10–7 M) in vitro, in which 10–7 M is supraphysiologically high. Eight-week-old female mouse endometrium was obtained 5.5 days after the injection of 1.25 IU or 20 IU equine chorionic gonadotropin, roughly during the embryo implantation window, to examine the in vivo effects of high E2 concentrations on mouse EECs.

Results

In vivo and in vitro experiments demonstrated decreased mitochondrial DNA contents and ATP formation after EECs were stimulated with supraphysiologically high E2 concentrations than those stimulated with a physiologic E2 concentration. Less prominent immunofluorescence mitochondrial staining, fewer mitochondria numbers under electron microscopy, lower 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide aggregate/monomer ratio, and greater reactive oxygen species (ROS) production were found after EECs were stimulated with supraphysiologically high E2 concentrations. The high E2-induced ROS production was reduced when EECs were pretreated with N-acetyl-cysteine in vitro, but remained unchanged after the pretreatment with coenzyme Q10.

Conclusion

High E2 concentrations increase extramitochondrial ROS production in EECs and subsequently result in mitochondrial dysfunction.
Autoimmune Pituitary Disease: New Concepts With Clinical Implications
Authors: Yamamoto Masaaki , Iguchi Genzo , Bando Hironori , Kanie Keitaro , Hidaka-Takeno Ryoko , Fukuoka Hidenori , Takahashi Yutaka
Published: September 2019

Some endocrine disorders, including hypophysitis and isolated adrenocorticotropic hormone (ACTH) deficiency, are caused by an autoimmune response to endocrine organs. Although the pathogenesis of some autoimmune endocrine diseases has been elucidated, it remains obscure for most.

Anti-PIT-1 hypophysitis (anti-PIT-1 antibody syndrome) is a newly described pituitary autoimmune disease characterized by acquired and specific growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies. This disorder is associated with a thymoma or neoplasm that ectopically expresses pituitary-specific transcription factor 1 (PIT-1) protein. Circulating anti-PIT-1 antibody is a disease marker, and PIT-1-reactive cytotoxic T cells (CTLs) play a pivotal role in disease development.

In addition, isolated ACTH deficiency appears to be caused by autoimmunity to corticotrophs; however, the pathogenesis remains unclear. A recently described case of isolated ACTH deficiency with large cell neuroendocrine carcinoma (LCNEC) showed ectopically expressed proopiomelanocortin (POMC), and circulating anti-POMC antibody and POMC-reactive CTLs were also detected. As CTL infiltrations around corticotrophs were also observed, isolated ACTH deficiency may be associated at least in part with a paraneoplastic syndrome.

Although several underlying mechanisms for pituitary autoimmunity have been proposed, these observations highlight the importance of paraneoplastic syndrome as a cause of pituitary autoimmune disease. In this review, we focus on the pathophysiology and connection of anti-PIT-1 hypophysitis and isolated ACTH deficiency and discuss the state-of-art knowledge for understanding pituitary autoimmunity.
Uterine fluid proteins for minimally invasive assessment of endometrial receptivity
Authors: Kasvandik Sergo , Saarma Merilin , Kaart Tanel , Rooda Ilmatar , Meikas Agne-Velthut , Ehrenberg Aivar , Gemzell Kristina , Lalitkumar Parameswaran Grace , Salumets Andres , Peters Maire
Published: September 2019

Context

Clinically used endometrial (EM) receptivity assays are based on transcriptomic patterning of biopsies at mid-secretory endometrium (MSE) to identify the possible displacement or disruption of window of implantation (WOI) in patients with recurrent implantation failure (RIF). However, biopsies are invasive and cannot be performed in the same cycle with IVF embryo transfer, while uterine fluid (UF) analysis is considered minimally invasive and can immediately precede embryo transfer.

Objective

To determine whether UF proteome can be used for WOI monitoring and whether it would highlight the etiology of RIF.

Patients

Paired early secretory endometrial (ESE) and MSE UF samples from six fertile control women for discovery, and additional 11 paired ESE/MSE samples from controls and 29 MSE samples from RIF patients for validation.

Results

Using discovery mass spectrometry (MS) proteomics we detected 3,158 proteins from secretory phase UF of which 367 undergo significant (q < 0.05) proteomic changes while transitioning from ESE to MSE. 45 proteins were further validated with targeted MS, and 21 were found to display similar levels between control ESE and RIF MSE, indicating displacement of the WOI. Panel of PGR, NNMT, SLC26A2 and LCN2 demonstrated specificity and sensitivity of 91.7% for distinguishing MSE from ESE samples. The same panel distinguished control MSE samples from RIF MSE with a 91.7% specificity and 96.6% sensitivity.

Conclusion

UF proteins can be used for estimating uterine receptivity with minimal invasiveness. Women with RIF appear to have altered MSE UF profiles that may contribute to their low IVF success rate.
epiflows: an R package for risk assessment of travel-related spread of disease
Authors: Moraga Paula , Dorigatti Ilaria , Kamvar Zhian N. , Piatkowski Pawel , Toikkanen Salla E. , Nagraj VP , Donnelly Christl A. , Jombart Thibaut
Published: September 2019

As international travel increases worldwide, new surveillance tools are needed to help identify locations where diseases are most likely to be spread and prevention measures need to be implemented. In this paper we present epiflows, an R package for risk assessment of travel-related spread of disease. epiflows produces estimates of the expected number of symptomatic and/or asymptomatic infections that could be introduced to other locations from the source of infection. Estimates (average and confidence intervals) of the number of infections introduced elsewhere are obtained by integrating data on the cumulative number of cases reported, population movement, length of stay and information on the distributions of the incubation and infectious periods of the disease. The package also provides tools for geocoding and visualization. We illustrate the use of epiflows by assessing the risk of travel-related spread of yellow fever cases in Southeast Brazil in December 2016 to May 2017.
Measurement Eccentricity the Moon’s Orbit with Image Analysis Technique by Using Tracker Software
Authors: Tanzilla Ricka , Jauhari Ishafit , Pramudya Yudhiakto
Published: September 2019

One of the interesting physical phenomenon to be studied is about eccentricity of the Moon's orbit on the movement of the Earth and the Moon as explained in Kepler's Law. In order to explain the phenomenon,several research has been done to determine the measurement accuracy of Moon disk diameter using Trackers and to know the result of the eccentricity value in the application of Kepler's Law. This research can produce eccentricity values accordance with the application of Kepler’sLaw. The research method used is Image Analysis Techniqueassisted with Tracker. The result of this research shows that the eccentricity value obtained is 0.07 ± 0.01. This is in accordance with Kepler's first Law which stated that orbits of each planet and satellite is an ellipse and has an eccentricity value of 0 <e <1. The value of eccentricity obtained has accuracy of 22%,if it compared with the actual value.Whereas, if it compared with the value of ephemeris then the value of accuracy is 8%.
Analysis of metacognition difficulties in problem-solving static fluid material in term of Hippocrates – Galenus personality type
Authors: Setyawati Eni , Susilawati Susilawati , Sulisworo Dwi
Published: September 2019

Describing student's metacognition difficulties and thinking the process in problem-solving static fluid material in each melancholic, sanguinic, phlegmatic, and choleric (Hippocrates - Galenus) personality type. This data analysis method uses a Likert scale as a measurement scale. The data analysis technique used was grouping data into four categories: Understanding The Problem, Devising A Plan, Carrying Out The Plan, Looking Back. The cause of students' metacognition difficulties caused by a lack of understanding the concept of physics, knowing symbols, formulations, notations, and calculations that will be done in each problem solving, and lack of understanding strategies in problem-solving. Students who had a melancholic, sanguinic, choleric personality type were students who had metacognition difficulties when understanding and solving the problem, and also had problems in considering strategies and realizing the use of using strategy. Students who had the Phlegmatic personality type were able to understand the problem by looking at the problem and then making an image so that it can change the information into the form of physics.
Variation of Mixed Banana peel Substrate and Cow Dung in Biogas Pressure as a Learning Source for Renewable Energy Sources
Authors: Puspitawati Puspitawati , Riswanto Riswanto , Suseno Nyoto
Published: September 2019

The supply of world energy resources is increasingly depleted. The abundance of cow manure and banana peel can cause environmental pollution. It can be used as raw material for biogas because both materials have a high methane gas ratio. This research is an experiment with six variations in the amount of mixture in each experiment. Results of the research on gas pressure and the best biogas production results using 1-litre banana peel substrate and 4-litre cow dung. Data shows that the gas pressure is faster and is greater when the pH of the mixture is acidic 6.2, the mixture is thick green and has a strong odour. Gas pressure on day 20 is obtained by 106421 Pascal. The average value of the results of the validation of the learning resources of the three aspects of an assessment is 82.3%; it shows that the poster can be used as a learning resource.
Abdominal aortic aneurysm screening programme
Authors: Peate Ian
Published: September 2019

This is the second article in a series of articles regarding screening programmes. In this article, an overview of the abdominal aorta is provided. The article also considers the abdominal aortic aneurysm screening programme. Aortic abdominal aneurysm is described. The majority of abdominal aortic aneurysms are asymptomatic; however, if there are any symptoms, these are explained.

All four UK countries offer men aged 65 years and over a screening opportunity using an ultrasound scan, the fundamental aspects of abdominal aortic aneurysm screening programmes is offered. It is emphasised that screening is not mandatory in the UK; the man has a right to decline the invitation to attend any screening programme.
Getting it right: the art of academic referencing
Authors: Duffy Anita , Lawler Fiona
Published: September 2019

In academic writing students are expected to find appropriate references for arguments they wish to include in their assignments, using a standard system of referencing. Referencing correctly allows readers to access the original source material easily and quickly and good referencing also shows evidence of research and reading regarding the topic of discussion. Academic institutions and tutors expect students to reference assignments clearly and accurately. In this article, the authors explain the why and how of academic referencing using the Harvard referencing style.
Bridging the skills gap: apprentice assistant practitioners having an impact in mental healthcare services
Authors: Morris Andy , Donovan Patricia
Published: September 2019

It is important to have a well-trained workforce and this is especially so in mental healthcare services. This article is the first of four looking at mental healthcare services and the apprentice assistant practitioner (AAP). The background to the introduction of assistant practitioners (AP), both in generic terms and more specifically their potential in mental health provision, will be explored.

The present situation in mental health services will be examined, along with how the AP role might help mitigate some of the critical challenges faced in this area of health. The development of higher apprenticeships will be discussed in relation to standardisation of the AP role and how universally recognised apprenticeship standards around knowledge, behaviours and values will aid a more consistent understanding of the AP position and their consequent deployment in services.
Assessing subclinical inflammation by peroxidase detection in patients with pressure ulcers
Authors: Kitamura Aya , Minematsu Takeo , Nakagami Gojiro , Miyagaki Tomomitsu , Sasaki Sanae , Hayashi Chieko , Sanada Hiromi
Published: September 2019

Objective:

This study aimed to examine the superiority of peroxidase detection of macroscopic observations using rat wounds, and to test the external validity of the peroxidase analysis in pressure ulcers (PU) in humans.

Method:

In the animal study, rat wounds were analysed. A cross-sectional study analysed, by wound blotting, exudate samples from full-thickness PUs. Peroxidase activity was divided into two groups (ring and non-ring signals). Scores in the ‘inflammation/infection’ and ‘necrotic tissue’ components of DESIGN, a classification tool of PUs, were compared between the groups.

Results:

In the animal study, 20 rat wounds were assessed and in the clinical study, 62 samples were collected from 26 full-thickness PUs of 21 patients aged ≥ 65 years. In the animal study, five of six wounds with clinical inflammation signs showed ring signal (defined as a signal on the wound edge and no signal on the wound bed). While the tissue sections of three wounds with a ring signal showed inflammatory features, they showed no clinical signs of ‘inflammation/infection’. In the clinical study, which analysed 630 ring and 32 non-ring signals, 13 samples in the ring signal group and five in the non-ring signal group had ‘inflammation/infection; scores of ≥1 (p=0.016). Despite having no clinical signs, 17 samples showed the ring signal.

Conclusion:

This study revealed the external validity of the wound blotting analysis of peroxidase and demonstrated its use to detect subclinical inflammation.
Acellular fish skin matrix on thin-skin graft donor sites: a preliminary study
Authors: Badois Nathalie , Bauër Pierre , Cheron Maxime , Hoffmann Caroline , Nicodeme Marguerite , Choussy Olivier , Lesnik Maria , Poitrine Florence Canoui , Fromantin Isabelle
Published: September 2019

Objective:

Surgery for head and neck cancer often requires free flap reconstructions, whose harvesting site often requires a thin-skin graft. Wounds from the thin-skin donor site are comparable to an intermediate or deep second-degree burn. This is uncomfortable and can lead to complications such as a long healing time, local infections and pain. Since they are reproducible, these wounds may serve as a model for an objective assessment of new healing medical devices. The acellular fish skin matrix is a new medical device designed to improve healing quality and time.

Methods:

We compared the outcomes between standard procedure and the use of this matrix placed on the split-thickness skin graft (STSG) donor site, in patients operated on in our centre for radial forearm free flap reconstruction for head and neck wounds.

Results:

There were 21 patients included. The healing time was halved when using the acellular fish skin matrix, from 68 to 32 days on average. Acellular fish skin matrix reduced pain levels and local infection. The visual analogue pain scale (VAS) was ≥3 at five days (p=0.0034) and infection rate reduced from 60% to 0% (p=0.0039).

Conclusion:

These results are extremely encouraging. However, it is important to take into account the relatively high cost of this matrix for its future indications. A larger study including an overall cost estimation and an assessment on different wound types would be interesting, to better target the indications of the acellular fish skin matrix.
Identification of carbon nanotube particles in liver tissue and its effects on apoptosis of birds exposed to air pollution
Authors: Al-Badri Ahmed Mahdi , Bargooth Ali Fayadh , Al-Jebori Jafar Ghazi , Zegyer Esraa Abdul Khaliq
Published: September 2019

Aim: This study aimed to distinguish carbon nanotube (CNT) particles and their pathological effects on the liver of birds in areas with carbon emissions. Materials and Methods: Twenty-one domestic ducks were collected from pure farmers and exposed to different sources of air pollution. Histological stains were used to detect the accumulation of carbon particles. In addition, acridine orange/ ethidium bromide staining was used to detect apoptosis, and scanning electron microscope (SEM) technique was used to determine the morphological design of carbon particles. Results: Light microscope results showed that the liver sections contain multiwalled CNTs (MWCNTs) which appear as black spots in the hepatic parenchyma. The histopathological changes of parenchyma include sinusoidal dilatation, infiltration, and congestion with frequently high number of macrophages. In general, early destruction of hepatic parenchyma was observed. Moreover, SEM results showed two morphological types of CNTs: The ball-shaped nanoparticles scattered as ultrafine carbon black and fiber form of carbon particles were recognized as MWCNTs in the hepatic tissue. Fluorescence microscopy results showed the early and progressive stages of apoptosis in the hepatic cells of birds in polluted areas, which can be related to the degree and exposure period to pollutants. Conclusion: The study indicates that liver morbidity of birds living in the farms affected by the pollution of brick factories is higher than the birds living in farms affected by the pollution of oil fields.
Molecular and phylogenetic study of Staphylococcus aureus isolated from human and cattle of Al-Qadisiyah Governorate, Iraq
Authors: Neamah Ahmed Jasim , Ayyez Hayder Naji , Klaif Saba Falah , Khudhair Yahia Ismail , Hussain Muthanna Hadi
Published: September 2019

Aim: This study was designed to detect the prevalence of Staphylococcus aureus, to estimate the frequency of methicillin resistance gene (mecA), femA (specific gene for S. aureus), and lukS gene, and the prevalence of urinary tract infection (UTI) in human and bovine mastitis caused by S. aureus. Materials and Methods: A total of 102 cases of S. aureus were included in this study; 72 specimens were isolated from human with UTIs and 30 specimens were isolated from milk of cattle with acute mastitis. Diagnosis was done by VITEK 2 Compact after subculture and purification. All isolates were examined for the presence of mecA, femA, and lukS (Panton- Valentine leukocidin) using multiplex polymerase chain reaction. Results: Culture and biochemical evaluation of the samples revealed the presence of S. aureus, among which the genes mecA, femA, and lukS were positively detected in 68 (94.4%), 36 (50%), and 20 (27.7%) of S. aureus isolates from methicillin-resistant humans, respectively. In the same manner, the genes mecA, femA, and lukS were positively detected in 27 (90%), 14 (46.7%), and 11 (36.7%) of S. aureus isolates from methicillin-resistant cattle. Sequencing of partial order of femA gene isolated from human isolate and from cattle with mecA isolated from human revealed high sequence identity with the National Center for Biotechnology Information (NCBI)-Basic Local Alignment Search Tool. S. aureus isolates and the phylogenetic analysis showed that there was a significant genetic similarity (0.5 genetic change) between human and animals isolates, and then, the gene sequences were deposited into NCBI-Genbank accession numbers MG696860.1 for mecA and femA from human, MG696861.1 for mecA and femA from cattle, MK474469.1 for mecA and femA gene from human, and MG696862.1 for mecA and femA gene from cattle. Conclusion: The study represents the first report of genetic relationship between S. aureus from humans and cattle of Iraq. Therefore, it is essential to define the role of animals as an important source of the distribution of pathogen related to public health. The continuous monitoring of methicillin susceptibility pattern of S. aureus isolates that have high standards of infections might prevent methicillin-resistant S. aureus transmission in either direction between human and cattle, the risk of dairy milk on humans, or self-direction between the same species.
DOCENTES LGBT: o que tem abordado as pesquisas contemporâneas?
Authors: Silveira Biazus Paula Hosana , Brancher Vantoir Roberto
Published: September 2019

O presente escrito trata-se de um levantamento bibliográfico, tendo por objetivo analisar as produções do “GT-23: Gênero, Sexualidade e Educação” das reuniões anuais da Associação Nacional de Pesquisa e Pós-Graduação em Educação do período que compreende os anos de 2008 e 2017. Dessa análise buscamos investigar os espaços dados e tomados pelos pesquisadores à discussão das especificidades da população LGBT enquanto docentes. Os resultados apontam para pouca discussão sobre docentes LGBT, nenhum alinhamento com a EBPTT e a ainda forte presença de heteronormatividade nos discursos sociais. Nesse sentido, entendemos que a ampliação das discussões permitem ofertar outras formas de fazer ver e fazer ser vista as docências LGBT.
ENTRE SILENCIAMENTOS E INVISIBILIDADES: AUSÊNCIA DE DISCUSSÕES CURRICULARES E POLÍTICAS INSTITUCIONAIS DE GÊNERO E SEXUALIDADE NA UNIVERSIDADE
Authors: Silva Elder Luan dos Santos
Published: September 2019

Esse texto tem como objetivo refletir os processos de silenciamentos e invisibilidades das questões de gênero e sexualidade nos currículos oficiais dos cursos de graduação e nas políticas institucionais de permanência e assistência estudantil da Universidade Federal do Recôncavo da Bahia. A abordagem ao tema foi qualitativa, e adotou-se a perspectiva da etnometodologia, através da realização de uma etnopesquisa implicada. A compreensão de universidade posta pelas estudantes, dão conta de um lugar que ao mesmo tempo em que apresenta-se como um terreiro de diversidades, propício para a saída do armário, vivência e expressão das sexualidades e gêneros não-binários e normativos, é também um espaço marcado por práticas de silenciamento e invisibilização, em especial nos espaços formais de aprendizagem, a exemplo da sala de aula. A instituição universitária tem permanecido inerte, e continua reforçando os discursos hegemônicos sobre gênero, sexualidade, sexo e corpo, sendo espaço de constante produção e reprodução lgbtfobias.
ANÁLISE DOS GRUPOS DE PESQUISA CADASTRADOS NA PLATAFORMA LATTES DO CNPq COM PRODUÇÃO CIENTÍFICA RELACIONADA COM A TRANSGENERIDADE
Authors: Hatje Luis Felipe , Pereira Lara Torrada , Da Silva Marcus Vinícius Tams
Published: September 2019

Essa pesquisa teve o objetivo de mapear os grupos de pesquisa registrados no Diretório de Grupos de Pesquisa do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) que discutam questões relacionadas com a transgeneridade e a produção científica vinculada ao líder do Grupo. Para o desenvolvimento da pesquisa foi realizado um levantamento de dados sobre grupos de pesquisa do Brasil cadastrados no Diretório dos Grupos de Pesquisa CNPq e, para a obtenção de dados complementares, sobre a produção científica dos líderes, utilizamos a Plataforma Lattes da mesma agência. Para a análise dos dados utilizou-se a metodologia de análise de conteúdo. Por meio de levantamento de dados, foram identificados 29 grupos, distribuídos por 22 instituições em todas as regiões do país, sendo 21 públicas e 01 particular. Por meio dos dados obtidos, verificou-se que a maioria dos grupos se concentram em áreas das humanas (62%) e áreas da saúde (21%).
ACADÊMICOS INDÍGENAS, QUILOMBOLAS E PESSOAS COM DEFICIÊNCIA NO ENSINO SUPERIOR: UMA ANÁLISE DA POLÍTICA DE INCLUSÃO ADOTADA PELA UNIVERSIDADE ESTADUAL DO SUDESTE DA BAHIA (UESB)
Authors: Alves Daniel Cardoso
Published: September 2019

A partir da perspectiva de universidade colorida, plural e diversa, este artigo tem como objetivo realizar uma análise qualiquantitativa da política de inclusão social adotada pela UESB, compreendida entre os anos de 2009 e 2017, em relação aos povos indígenas, quilombolas e às pessoas com deficiência. Como procedimentos metodológicos, utiliza-se da revisão bibliográfica e da pesquisa documental. A técnica adotada para o tratamento dos dados é a análise de conteúdo. Entre os achados, constata-se que: 83% das vagas destinadas a esses sujeitos encontram-se ociosas, 37% dos que ingressaram foram evadidos e 23% conseguiram concluir os cursos. Entretanto, ainda que esses dados sejam preocupantes, entende-se que a simples presença de seguimentos excluídos de lugares que, tradicionalmente, não deveriam lhes pertencer, representa o início da mudança do paradigma dos estereótipos negativos e a possibilidade de um novo imaginário social acerca dos povos indígenas, dos quilombolas e das pessoas com deficiência no Brasil.
ENTRE AS BRECHAS E AS GRADES DE PEDAGOGIA: TRANSBORDAMENTOS DAS QUESTÕES DE GÊNERO E SEXUALIDADES
Authors: De Oliveira Johnny Chaves
Published: September 2019

O presente artigo objetiva compreender como os currículos de Pedagogia abordam as temáticas de gênero e sexualidades na formação docente. Como referencial teórico, adota-se as reflexões de Michel Foucault, Joan Scott, Judith Butler, além de outros/as do campo da formação docente. Enquanto opção metodológica, foi realizada análise documental e de conteúdo dos projetos político-pedagógicos dos cursos, das ementas e dos programas das disciplinas analisadas. Além disso, foram entrevistados/as oito professores/as-formadores/as pertencentes à UERJ e à UNIRIO, posto que ambas as instituições apresentam disciplinas obrigatórias cujas ementas, expressamente, pretendem trabalhar com estas temáticas. Das análises podemos extrair que múltiplas práticas e investimentos pedagógicos criativos, por vezes de abrangência interseccional, caracterizam uma noção ampliada de currículo. Como conclusão, temos que as múltiplas formações destes profissionais contribuem para uma sensibilidade enquanto competência política-pedagógica para a afirmação da diversidade em suas práticas didáticas.
Modelo matemático para estimativa da depleção natural de hidrocarbonetos de petróleo a partir de perfis verticais de temperatura
Authors: Peres Caio Brito , Schneider Marcio Roberto , Giachini Admir José , Souza André Moreira
Published: September 2019

Em áreas contaminadas os hidrocarbonetos de petróleo são encontrados na forma de líquido imiscível menos denso que a água (Light Non-Aqueous Phase Liquids – LNAPL). O processo de biodegradação natural desses contaminantes é conhecido como depleção natural na zona da fonte, do inglês Natural Source Zone Depletion (NSZD). Para sua aplicação, é necessária a medição das taxas de NSZD, de forma a demonstrar que a eficácia da biodegradação natural do LNAPL como uma solução eficaz, econômica e sustentável na gestão de passivos. Estudos recentes apresentam relações diretas entre a temperatura do solo e a ocorrência da NSZD. Nesse contexto, o objetivo desse trabalho é apresentar um novo modelo para estimar a depleção da massa de LNAPL em função da variação de temperatura na fonte de contaminação. Com base na geração de dados sintéticos de temperatura do solo, foram comparados os resultados do modelo desenvolvido com os resultados dos modelos propostos por Warren e Bekins (2015) e Stockwell (2015). A análise comparativa revelou que os modelos de Warren e Bekins (2015) e Stockwell (2015) mediram apenas 30 e 51% do calor na zona da fonte de contaminação, respectivamente. Os resultados da comparação apontam para a importância em se considerar a variação vertical dos parâmetros térmicos do meio poroso na zona da fonte, em particular a condutividade térmica, no cálculo do transporte do calor do solo.
A internacionalização da Revista Clínica de Ortodontia Dental Press
Authors: Almeida Marcio
Published: September 2019

"Gostaria de dividir com todos os leitores que a nossa querida Revista Clínica de Ortodontia Dental Press (RCODP) passará, a partir do ano que vem, pelo processo de internacionalização. Isso mesmo: a partir de 2020, passaremos a internacionalizar a nossa revista e disponibilizaremos nossos artigos também em língua inglesa. Esse ano, de fato, tem sido marcante para a revista, pois, como mencionamos em editorial passado, recebemos em março a grata informação de que a RCODP seria incorporada no rigoroso processo de indexação da base de dados internacional SCOPUS, que é a maior base de dados de resumos e referências bibliográficas de literatura científica revisada por pares. E o leitor poderia perguntar: qual é a vantagem de internacionalizar uma revista clínica de Ortodontia brasileira? A resposta é simples: continuar evoluindo!" [...]
A Ortodontia e o periodonto: coisas que devemos saber - Parte II
Authors: Janson Marcos
Published: September 2019

"Na Parte 1 desse artigo, foi descrito o que fazer na presença de recessões em raízes mal posicionadas. O assunto continua sendo descrito; agora, trataremos sobre quais procedimentos devem ser tomados quando há presença de recessões mas a posição radicular não é a etiologia primária." [...]
Protocolo de utilização do Aparelho de Protração Mandibular: dicas para um melhor desempenho clínico
Authors: Rosa Wilson Guilherme Nunes
Published: September 2019

"A utilização dos propulsores mandibulares na correção da má oclusão da Classe II tem se intensificado nas últimas décadas. No Brasil, o APM, idealizado pelo Prof. Carlos Martins Coelho Filho, ganhou notoriedade e tem sido largamente utilizado em cursos de especialização e por profissionais, na prática clínica ortodôntica diária. O APM é um propulsor mandibular rígido e tem como vantagem a possibilidade de ser utilizado concomitantemente à aparelhagem ortodôntica fixa, reduzindo o tempo de tratamento. Por ser um aparelho fixo, depende menos da cooperação dos pacientes; pode ser utilizado com ativação diferencial ou, até mesmo, unilateralmente, para correção das Classes II assimétricas." [...]
Torque anterior
Authors: Bastos Marden
Published: September 2019

"Em qualquer prescrição de braquetes, precisamos, em alguns casos, individualizar o torque do segmento anterior. O exemplo mais comum é o caso de extração de pré-molares, em que, durante a retração anterior, apesar de todos os cuidados, ocorre a lingualização das coroas dos incisivos, entre outros casos. Podemos fazer o torque anterior com dois alicates 442." [...]
Protocolo diferencial para a técnica MARPE em pacientes com variação no volume ósseo do palato
Authors: Cury Sérgio Elias Neves , Mondelli Adriano Lia , André Cristiane Barros , Iared Walter , Guerra José Gregório Pelayo , Rovira Jessica , Berni Laila
Published: September 2019

INTRODUÇÃO: A expansão rápida da maxila assistida por mini-implantes (MARPE) vem sendo a principal opção de tratamento ortopédico transversal da maxila para pacientes adultos jovens, que já atingiram determinada maturação esquelética. A fina espessura óssea na região palatal é uma das limitações da técnica. OBJETIVO: o propósito do atual artigo é apresentar, por meio de dois casos clínicos, uma alternativa para essa situação, com a modificação do protocolo para técnica MARPE, utilizando dois mini-implantes adicionais na região anterior do palato. RESULTADO: observou-se disjunção significativa da sutura palatina mediana com o disjuntor modificado. CONCLUSÃO: os casos aqui apresentados sugerem que os passos clínicos utilizando o protocolo proposto mostraram- se eficazes para expansão esquelética da maxila em paciente adulto jovem com pouca espessura óssea na região palatal, oferecendo uma solução menos invasiva e menos onerosa do que a expansão cirurgicamente assistida, atual padrão-ouro para esse tipo de tratamento.
Analisis Kualitatif dan Kuantitatif Kandungan Boraks Pada Bakso Menggunakan Kertas Turmerik, FT – IR Spektrometer dan Spektrofotometer Uv -Vis
Authors: Suseno Dedy
Published: September 2019

Bakso merupakan salah satu makanan yang banyak dikonsumsi karena penyajiannya yang praktis, memiliki harga yang terjangkau dan banyak tersedia diberbagai tempat seperti pasar tradisional, pasar swalayan dan masih banyak lagi. Banyaknya masyarakat yang mengonsumsi bakso membuat para pedagang berlomba-lomba membuat bakso yang enak, namun dengan alasan kualitas dan awet ada pedagang yang menggunakan boraks sebagai bahan tambahan pangan. Boraks merupakan senyawa kimia yang mengandung unsur Boron (B) dan memiliki nama dagang bleng, pijer atau gendar. Boraks biasa digunakan sebagai bahan solder, pembuatan gelas, bahan pembersih/pelicin porselin, pengawet kayu dan antiseptik kayu. Penelitian terhadap bakso dikota Medan menunjukkan bahwa 8 dari 10 sampel bakso yang diperiksa ternyata mengandung boraks dengan konsentrasi 0,08% - 0,29%. Menurut Peraturan Menteri Kesehatan RI No 033 tahun 2012 tentang bahan tambahan pangan, boraks merupakan salah satu dari jenis bahan tambahan pangan yang dilarang digunakan dalam produk makanan. Tujuan penelitian ini adalah mengidentifikasi adanya boraks pada bakso sapi secara kualitatif maupun kuantitatif. Hasil analisis boraks menggunakan kertas turmerik menunjukkan bahwa perubahan warna pada kertas turmerik hanya terjadi pada kontrol positif saja sedangkan analisis boraks menggunakan FTIR Spektrometer semua sampel dan kontrol positif tidak menunjukkan adanya spektrum sidik jari pada bilangan gelombang 1500 sampai 1000 cm-1. Hasil analisis boraks menggunakan spektrofotometer Uv-Vis menunjukkan bahwa 9 dari 12 positif mengandung boraks dengan konsentrasi terbesar pada sampel B1 sebesar 2414.375 µg/mL.
„Tylko życie poświęcone innym warte jest przeżycia”Problemy zawodu lekarza
Authors: FLORCZYK KAROLINA
Published: September 2019

Celem artykułu jest identyfikacja ryzyka i problemów zawodowych w grupie lekarzy medycyny. W części pierwszej autorka analizowała stopień ryzyka różnych czynników: niebezpiecznych (urazowych, wypadkowych), szkodliwych (fizyczne, chemiczne, biologiczne i psychofizyczne), a także wymagania stanowiskowe i możliwości rozwoju zawodowego w Polsce. W drugiej części, na bazie dostępnych wyników badań, zostały wskazane czynniki wpływające na stan zdrowia lekarzy, określone przez warunki pracy i godziny pracy, czynniki stresujące oraz uzależnienia. W trzeciej części zostały zaprezentowane aktualne dobre praktyki i możliwe ozwiązania tych problemów, które jednocześnie są przyjazne dla lekarzy.
Manfred Liebel i Urszula Markowska-Manista, Prawa dziecka w kontekście międzykulturowości. Janusz Korczak na nowo odczytany, Warszawa, Wydawnictwo Akademii Pedagogiki Specjalnej, 2017, ss. 242.
Authors: SOWA-BEHTANE EWA
Published: September 2019

Recenzja
Rational quartic symmetroids
Authors: Helsø Martin
Published: September 2019

We classify rational, irreducible quartic symmetroids in projective 3-space. They are either singular along a line or a smooth conic section, or they have a triple point or a tacnode.
Myopic Mergers across Borders with Incomplete Information in GOLE
Authors: Beladi Hamid , Chakrabarti Avik , Hollas Daniel
Published: September 2019

In this paper, we present a tractable general equilibrium model capturing the incentives for myopic mergers in oligopolistic industries with incomplete information about rivals’ costs. We demonstrate that ex-ante gains from myopic mergers between firms with incomplete information about rival’s cost are larger when the difference between unknown components of their costs is wider. We also show that ex-ante gains from myopic mergers between firms across countries with large differences in factor endowments, ceteris paribus, would be greater than the ex-ante gains from mergers between countries with relatively similar factor endowments.
Near Zero Parameter Metamaterial Inspired Superstrate for Isolation Improvement in MIMO Wireless Application
Authors: Mark Robert , Das Soma
Published: September 2019

In this paper, near zero parameter based metamaterial superstrate is presented for mutual coupling reduction in multiple-input-multiple-output (MIMO) antenna. The proposed design offers a peak isolation of 38 dB with edge-separation of 0.042λ0 at resonating frequency. To verify the simulations results, a prototype of the proposed antenna is fabricated and experimentally measured. The two elements MIMO is designed with measured impedance bandwidth of 5.6 to 5.95 GHz with a peak measured gain of 7.4 dBi and efficiency above 95 %.The measurement established an isolation enhancement of 30 dB with minimum correlation coefficient of 0.05 within operating band. The proposed method offers a good design technique for high gain and closely packed MIMO antenna system for WLAN applications.
Coloring social change: Humor, politics, and social movements
Authors: Takovski Aleksandar
Published: September 2019

As many social movements demonstrate, humor can serve as an important resource to resist oppression, fight social injustice and bring social change. Existing research has focused on humor’s role within social movements and its positive effects on the free expression of criticism, reduction of fear, communication, mobilization of participants and so on. However, the current literature on the activist use of humor also expresses some reservations about its political efficacy. While humor may steam off the energy necessary to counteract oppression and injustice, other tools of achieving the same political ends have been successfully deployed, primarily social media. Building upon this research, the present case study explores the 2016 Macedonian social movement called the Colorful Revolution. In particular, through the analysis of social media and activists’ reflection on the political use of humor, this case study examines how on-line humor contributed to the emergence and development of the movement. Factoring in activists’ opinions on the role of humor in society and especially in movements, while also paying attention to the role of social media, this case study tends to re-interpret the role of humor in the totality of the actions and circumstances underpinning the development of a social movement.
Promoting Effects of Al on Ni-Based Catalyst for the Hydrodeoxygenation Performance of Ethyl Acetate
Authors: Miao Caixia , Wang Fengjiao , Zhou Guilin , Xie Hongmei , Jiao Zhaojie , Zhang Xianming
Published: September 2019

The mesoporous Ni20/Al-KIT-6 (denoted as N20AxK) catalysts with different Al content (1–9 wt%) were prepared, metal Ni and KIT-6 modified by Al were used as active component and support, respectively. The physicochemical properties of the prepared N20AxK catalysts were characterized by H2-TPR, XRD, BET, TEM, and H2-TPD. The catalytic hydrodeoxygenation(HDO) performance of N20AxK catalysts was evaluated by ethyl acetate catalytic HDO. The results show that the catalytic HDO performance of the prepared N20AxK catalysts is related to the adsorption and activation performance for H2 molecules, as well as the dispersion of matal Ni active components. N20A5K catalyst shows the best H2 adsorption property and Ni dispersion. N20A5K catalyst presents superior catalytic HDO performance. At 300 °C and atmospheric pressure, the conversion of ethyl acetate and ethane selectivity of N20A5K catalyst are 99.3 % and 97.4 %, respectively. Besides, the N20A5K catalyst exhibits good stability.
Comparing the effects of cold compress and Xyla-p cream on hemodynamic changes in hemodialysis patients during venipuncture
Authors: Ghoreyshi Ziba , Amerian Monireh , Amanpour Farzaneh , Mohammadpourhodki Reza , Ebrahimi Hossein
Published: September 2019

Background

The vital signs reflect the physiological state of patients in various clinical conditions. The purpose of this study was to compare the effects of cold compress and Xyla-P cream on hemodynamical changes during venipuncture in hemodialysis patients.

Methods and Material

In this clinical trial study, 50 patients under hemodialysis were selected by simple random sampling. The patients were then randomly assigned to either Xyla-P cream, cold compress or placebo groups. The vital signs (blood pressure and pulse) were measured upon two intermittent hemodialysis sessions before and after venipuncture. Data were analyzed using repeated measures analysis of variance.

Results

The mean alternation in systolic blood pressure was significantly different comparing the placebo and cold compress groups before and after intervention (p<0.001). However, the difference was not significant between the Xyla-P cream group and either placebo (p=0.402) or ice compress (p=0.698) groups. The difference of the mean diastolic blood pressure was significant comparing the placebo group with either the Xyla-P cream group (p=0.003) or cold compress group (p<0.001) before and after intervention. In addition, there was a significant difference in the mean number of heartbeats comparing the control group with either the Xyla-P cream group (p<0.001) or cold compress group (p<0.001) before and after the intervention.

Conclusions

Considering the beneficial effects of ice compress and the Xyla-P cream on reduction of cardiovascular parameters, it is recommended to use these methods in hemodialysis patients during venipuncture.
Die Reform der Arbeitslosenversicherung
Authors: Jung Philip , Kuhn Moritz
Published: September 2019

Versicherungsschutz für den Einzelnen und darin angelegte Fehlanreize, welche die Gemeinschaft belasten, müssen in einem Arbeitslosenversicherungssystem gegeneinander abgewogen werden. Durch die Hartz-Reform der Jahre 2003 bis 2005 wurde dieser Zielkonflikt grundlegend neu ausgestaltet. Seither wird darüber gestritten, welche Auswirkungen die Reform auf die Entwicklung der Arbeitslosigkeit in Deutschland hatte. Philip Jung und Moritz Kuhn zeichnen die Entwicklung auf dem Arbeitsmarkt seit der Hartz-Reform aus dem Blickwinkel neu erschlossener Mikrodaten nach und geben einen Überblick über die Forschung zur Frage, welche kausale Wirkung die Hartz-Reform auf die Arbeitslosigkeit hatte. Sie zeigen, dass die Hartz-Reform nur moderat durch eine Stärkung der Suchanreize von Arbeitslosen gewirkt hat. Große Effekte hingegen habe es durch einen starken Rückgang der Kündigungen gegeben. Die Autoren skizzieren kurz die daraus folgenden Politikimplikationen.
Radical bilingualism in Junot Díaz’s texts
Authors: Derrick Roshawnda A.
Published: September 2019

This paper analyzes Junot Díaz’s most recent worksThe Brief Wondrous Life of Oscar Wao(2007.The brief wondrous life of Oscar Wao. New York: Riverhead) andThis is How You Lose Her(2012.This is how you lose her. New York: Riverhead) by using Muysken’s (2000.Bilingual speech. A typology of code-mixing. Cambridge: CUP) typology of code-switching to illustrate the types of language mixing devices present in these two texts. I point out that Díaz’s innovative use of radical bilingualism is not due to the quantity of sentences including Spanish, rather to the quality of mixing and switching in his works. Further, I elaborate on Casielles-Suárez, Eugenia. (2013. Radical code-switching in the Brief wondrous life of Oscar Wao.Bulletin of Hispanic Studies90. 475–487) study using Torres’ (2007. In the contact zone: Code-switching strategies by Latino/a writers.MELUS32(1). 75–96) categorization of code-switching strategies utilized by U.S. Hispanic authors. I find that instead of Díaz’s textsgratifying the bilingual reader(Torres. 2007. In the contact zone: Code-switching strategies by Latino/a writers.MELUS32(1). 75–96) or creatingradical hybridism(Casielles-Suárez. 2013. Radical code-switching in the Brief wondrous life of Oscar Wao.Bulletin of Hispanic Studies90. 475–487), that these two works illustrate radical bilingualism. In contrast to the majority of U.S. Spanish-English bilingual texts, which incorporate Spanish by using simple insertions, translations, bold font and italics, Díaz creates radically bilingual works by using a variety of Spanish and English varieties, the indirect influence of Spanish in monolingual English sentences, intra-word insertions, a diversity of insertion types and hybrid noun-phrases.
Comunidad de algas del manglar de playa Estrella, isla Colón, Bocas del Toro, Panamá
Authors: Rios Rosemary , Tejada Olga L. , Morales Diana , Miranda Elvia , Cerrud Angélica
Published: September 2019

Desarrollamos un estudio exploratorio descriptivo, de las especies de macroalgas que crecen asociadas a las raíces de R. mangle en playa Estrella, isla Colón, Bocas del Toro, Panamá, en agosto de 2012. El objetivo principal del estudio fue recolectar y describir las especies de algas encontradas y conocer la distribución vertical que forman en sus raíces. Para conocer la zonación vertical, en cada raíz se crearon tres zonas: 1) zona baja, desde la base de la raíz hasta 0.50 m de altura, 2) zona media de 0.50 m a 1.10 m y 3) zona alta, de 1.10 a 1.30 m., de acuerdo con Peña-Salamanca (2008). Se identificaron once especies del phylum Rhodophyta, de las cuales B. montagnei, B. moritziana, B. tenella, Polysiphonia howei, P. scopulorum, A. spicifera y C. caespitosa fueron las más sobresalientes. Del phylum Chlorophyta se recolectaron e identificaron tres especies: C. linum, B. verticillata y Chlorodesmis sp.  Respecto a la distribución vertical establecida por las algas en las raíces, la mayoría de especies se distribuyeron en las zonas baja y media y solamente el alga B. montagnei en la parte alta.  Con el estudio se espera contribuir al conocimiento de la ficoflora de los manglares del Caribe de Panamá.