bluuebunny/crossref_metadata_2025 huggingface dataset:
Implication of fast shear wave azimuth and critically stressed fractures in a coalbed methane reservoir
Authors: Banerjee Abir , Bhattacharyya Gautam , Lugun Nawin , Das Aloke , Johri Aditya
Published: May 2024

The orientation of the fractures and stresses within coal seams plays a critical role in gas production from coalbed methane reservoirs. In this study, we used resistivity images and sonic logs to investigate these parameters, aiming to (1) establish the relationship between fracture orientations and the polarization angles of fast shear waves and (2) detect active fractures in the coal seam. Shear waves in anisotropic formations are split into fast and slow components, with Alford’s rotation method used to determine the polarization angles of the fast shear wave. We found that the fast shear wave aligns with the direction of higher fracture intensity. Subsequently, we incorporated the poroelastic strain model to estimate the vertical ([Formula: see text]), maximum horizontal ([Formula: see text]), and minimum horizontal ([Formula: see text]) stresses in the wellbore. These stress magnitudes aided in identifying the faulting regime and were corroborated by vertical opening mode fractures. Validation of [Formula: see text] and [Formula: see text] involved comparisons with the breakout width in image logs and the closure pressure observed during hydraulic fracturing treatments. Applying Mohr’s Coulomb criteria, the stress model discerned the state of the fractures, transforming the stress magnitudes into shear and effective normal stress on each fracture plane. Our observations indicated that the identified fractures existed in a noncritically stressed condition, suggesting a lack of interconnectivity among them. These findings correspond to the absence of gas production to date, providing insights into the dynamics of fractures and their impact on production behavior.
Automated, High-Throughput Platform to Generate a High-Reliability, Comprehensive Rectal Cancer Database
Authors: Bhutiani Neal , Yousef Mahmoud M.G. , Yousef Abdelrahman , Zeineddine Mohammad , Knafl Mark , Ratliff Olivia , Fernando Uditha P. , Turin Anastasia , Zeineddine Fadl A. , Jin Jeff , Alfaro-Munoz Kristin , Goldstein Drew , Chang George J. , Kopetz Scott , Shen John Paul , Uppal Abhineet
Published: May 2024

PURPOSE

Dynamic operations platforms allow for cross-platform data extraction, integration, and analysis, although application of these platforms to large-scale oncology enterprises has not been described. This study presents a pipeline for automated, high-fidelity extraction, integration, and validation of cross-platform oncology data in patients undergoing treatment for rectal cancer at a single, high-volume institution.

METHODS

A dynamic operations platform was used to identify patients with rectal cancer treated at MD Anderson Cancer Center between 2016 and 2022 who had magnetic resonance imaging (MRI) imaging and preoperative treatment details available in the electronic health record (EHR). Demographic, clinicopathologic, tumor mutation, radiographic, and treatment data were extracted from the EHR using a methodology adaptable to any disease site. Data accuracy was assessed by manual review. Accuracy before and after implementation of synoptic reporting was determined for MRI data.

RESULTS

A total of 516 patients with localized rectal cancer were included. In the era after institutional adoption of synoptic reports, the dynamic operations platform extracted T (tumor) category data from the EHR with 95% accuracy compared with 87% before the use of synoptic reports, and N (lymph node) category with 88% compared with 58%. Correct extraction of pelvic sidewall adenopathy was 94% compared with 78%, and extramural vascular invasion accuracy was 99% compared with 89%. Neoadjuvant chemotherapy and radiation data were 99% accurate for patients who had synoptic data sources.

CONCLUSION

Using dynamic operations platforms enables automated cross-platform integration of multiparameter oncology data with high fidelity in patients undergoing multimodality treatment for rectal cancer. These pipelines can be adapted to other solid tumors and, together with standardized reporting, can increase efficiency in clinical research and the translation of actionable findings toward optimizing patient outcomes.
The Traditional New Woman and Emerging New Man in Republican China
Authors: Lang Wang
Published: May 2024

This study focuses on the agony of married New Women, as well as the emerging New Man, in the 1920s and 1930s. While the New Woman in love has attracted considerable scholarly attention, the dilemma of New Women after marriage remains mostly ignored. Relying on literary works as well as articles in newspapers and periodicals, this essay attributes the New Woman's acute dissatisfaction to the uncontested gendered division of labor and the discontinuity between romantic relationships and institutionalized marriage. Intellectuals proposed communal childcare as the solution to the New Woman's dilemma; however, this still left the gendered labor division intact. This essay identifies the traditional role of the New Woman in the family and observes the emergence of xianfu liangfu (賢夫良父, “good husband and wise father”), a counterpart to xianqi liangmu (賢妻良母, “good wife and wise mother”). This understudied discourse demands equal responsibility at home and an attentive fatherhood from men.
Making Unlikely Queer Worlds
Authors: Avishai Orit
Published: May 2024

Religion and queer lives are often thought about as antithetical, but for some LGBTQ+ persons disaffiliation is not an option. Instead, religious LGBTQ+ people seek to carve out livable spaces within their faith traditions: they make what queer theorists call “queer worlds.” This article describes the making of one such queer/religious world and considers the plausibility of applying the lens of queer worldmaking in conservative religious and political contexts that do not seem to conform to queer visions of counterculture and counter-publics. The article draws from a larger project on the activism, identities, communities, and lived experiences of Orthodox LGBT Jews in Israel, with a specific focus on Orthodox gays and lesbians. The article considers how respondents negotiate with and transform religious (and religious adjacent) everyday spaces, practices, and discourses as examples of religious queer worldmaking, with the implication that religious acts are among the range of creative acts that are part of queer worldmaking. The article makes an empirically informed case for a queer worldmaking project that is grounded in everyday religious practice, ritual, and scriptural interpretations.
Revisiting the Gay, Jewish Bicycle-Rider
Authors: Strassfeld Max
Published: May 2024

This article examines the analogy between gays and Jews in John Boswell’s scholarship in order to analyze the role of Jewishness in the construction of the field of history of sexuality. Boswell argues that Jews and gays have a similar social status throughout history until contemporary times, when gays continue to struggle while Jews have found a measure of social acceptance. The difference between them, according to Boswell, is that Jews pass down survival knowledge from within Jewish families, while gays are not generally born into gay families. While critiquing the sexual, racialized, and gendered politics of Boswell’s analogy, this article will argue that the current antitrans political moment requires us to return to the fundamental questions that Boswell poses about the relationship between history, the historian, intergenerational knowledge transmission, and communal survival.
Resounding Shadows
Authors: Smythe SA
Published: May 2024

This creative-critical essay is a refracted meditation on the spirit of sound and shadow-work through SA Smythe’s original sound composition and performance activation {spirit  forged} (2023), with accompanying visual documentation. The work was in part a response to Amartey Golding’s Spring 2023 installation, In the comfort of embers, commissioned by the Power Plant Contemporary Art Gallery in Tkaronto. Smythe reflects on the ecology of thought that laid the foundation for their own transmedia theories and practices, including moments of ancestral whispers, the interplay of light and darkness, sonic alchemy, and abiding reverence for the problematic of Black belonging. Delving into sound and its intimate vessels in a meditation on cultural memory, “Resounding Shadows” revels in liminal fusion of form, inviting the reader to join the traversal of spirit work where personal and collective journeys intertwine.
Georges Pletho Gemistus: Reforming Byzantium at the edge of the cliff
Authors: Christias Panagiotis
Published: May 2024

Pletho’s turn to the ancient Gods and Plato signifies actually a turn to the future of the national State. A well-defended country is a well-organized one. In order to be well-organized, the government and administration should be founded on the general national interest, for only national ideology brings the necessary stability and moral force to the long battle for Greek national survival. No wonder that scholars such as Sathas and Zakythinos consider him to be the first of the moderns, putting in the centre of his universe his mystical ideal of στρατιῶται (soldiers).
Από τον ποιητικό και εικαστικό Ρίτσο στους Γερμανούς εξπρεσιονιστές ζωγράφους
Authors: Αμπατζόγλου Άννα
Published: May 2024

Αντικείμενο μελέτης της ανά χείρας διατριβής αποτελεί το ποιητικό έργο του Γιάννη Ρίτσου που συνεγράφη κατά την περίοδο της επταετούς στρατιωτικής δικτατορίας – συγκεκριμένα, από την συλλογή Τέταρτη Διάσταση έως την συλλογή Γίγνεσθαι – ιδωμένο μέσα από ένα διακαλλιτεχνικό/διαμεσικό ερμηνευτικό πρίσμα. Ειδικότερα, μας απασχολεί το ζήτημα της (ανα)παράστασης, οι διαφορετικοί, δηλαδή, τρόποι οπτικοποίησης της εκφραστικής έντασης στα σημεία πύκνωσης του ποιητικού λόγου του Ρίτσου, με τέτοιον τρόπο ώστε τα οπτικά-και-λεκτικά, ριζωματικά αρθρωμένα, μεγέθη να εξέχουν ανάγλυφα από το ρηματικό. Προκειμένου αυτό να καταστεί σαφές, διατρέχουμε εικαστικά παραδείγματα του γερμανικού εξπρεσιονισμού, εντός των οποίων εγγράφεται και θεματοποιείται το αισθητηριακά προσληφθέν σοκ της παροντικά αναδυόμενης στιγμής ως παραμόρφωση των εξεικονιζόμενων μεγεθών και, επομένως, ως ανατροπή των οπτικών σχέσεων. Σε αυτό το πλαίσιο, μελετώνται από κοινού τα εν λόγω διεστώτα εκφραστικά μέσα (της ποίησης και της ζωγραφικής), προκειμένου να διερευνηθούν τα σημεία σύγκλισης και απόκλισής τους. Στόχος της παρούσας μελέτης είναι ο εντοπισμός και η ανάλυση των παραμέτρων εκείνων που εντάσσουν τον ποιητικό λόγο του Ρίτσου στο αισθητικό παράδειγμα του μοντερνισμού, όπως είναι, για παράδειγμα, η κατάλυση του γραμμικού χρόνου και η ακόλουθη αναδιάρθρωσή του, η ζωγραφικής και γλυπτικής τάξεως απόδοση του ενεστωτικά αναδυόμενου Συμβάντος που φέρει ιδιαίτερα υλικό ποιόν, το ζήτημα της χιασματικής παρουσίας/απουσίας του χωροποιημένου οπτικού/απτικού όγκου, καθώς και η πολυεπίπεδη θεματοποίηση των ορατών και αθέατων όψεων της πραγματικότητας ως συγχρονικά αναδυόμενες.
Εξωνομοθετικοί φορείς διαμόρφωσης του ενωσιακού δικαίου ανταγωνισμού
Authors: Χατζηϊωάννου Αντώνιος
Published: May 2024

Η διαμόρφωση του ενωσιακού δικαίου ανταγωνισμού στις Υπηρεσίες Γενικού Οικονομικού Συμφέροντος (ΥΓΟΣ) από τους εξωνομοθετικούς φορείς, ήτοι την Ευρωπαϊκή Επιτροπή (υπό τη διοικητική της έκφανση), το Δικαστήριο της Ευρωπαϊκής Ένωσης (ΔΕΕ) και τη Θεωρία, μέσα από την ανάλυση των εργαλείων που διαθέτουν και των λειτουργιών που επιτελούν.
Η επιβάρυνση σε αγώνες ποδοσφαίρου νέων υψηλού επιπέδου κατά τον ετήσιο προπονητικό κύκλο
Authors: Κομσής Θεοχάρης
Published: May 2024

Σε έναν αγώνα ποδοσφαίρου οι νεαροί ποδοσφαιριστές καλύπτουν συνολική απόσταση που κυμαίνεται από 7.000 έως 10.000 μ. και εκτελούν από 52 έως 100 επιταχύνσεις, ενώ αλλάζουν δραστηριότητα 1379 έως 1459 φορές, κάθε 4΄΄. Ο χρόνος που απαιτείται για την πλήρη αποκατάσταση των ποδοσφαιριστών μετά από έναν αγώνα μπορεί να φτάσει μέχρι και τις 72 ώρες. Παρά την προφανή αναγκαιότητα για προγράμματα αποκατάστασης, παρατηρείται κενό στην επιστημονική κοινότητα για την εγκυρότητα των μεθόδων αποκατάστασης. Σκοπός της έρευνας αυτής ήταν να διερευνηθεί η επίδραση συγκεκριμένων πρωτοκόλλων αποκατάστασης, σε επιλεγμένους νευρομυϊκούς και βιοχημικούς δείκτες που σχετίζονται με την απόδοση των αθλητών μετά από επίσημο αγώνα ποδοσφαίρου. Στο δείγμα της έρευνας συμμετείχαν 42 (n=42) νεαροί αθλητές ποδοσφαίρου υψηλού επιπέδου, ηλικίας 16 έως 22 ετών χωρίς προβλήματα τραυματισμών. Οι 18 αποτέλεσαν την ομάδα ελέγχου (n=18) και οι 24 την πειραματική ομάδα (n=24) οι οποίοι χωρίσθηκαν με τυχαίο τρόπο σε 3 επιμέρους ομάδες των 8 ποδοσφαιριστών. Οι μετρήσεις περιελάμβαναν την καταγραφή των σωματομετρικών στοιχείων και της σύστασης του σώματος, νευρομυϊκών δεικτών απόδοσης καθώς και βιοχημικών δεικτών μετά από αιμοληψία. Συγκεκριμένα, πραγματοποιήθηκαν τρεις μετρήσεις για κάθε αγώνα η 1η στις 24 ώρες πριν, η 2η στις 24 μετά και η 3η στις 48 ώρες μετά από αυτόν. Τα εξωτερικά φορτία επιβάρυνσης από τον κάθε αγώνα καταγράφηκαν χρησιμοποιώντας σύστημα τηλεμετρίας μικρής εμβέλειας και τριαξονικό επιταχυνσιόμετρο ενσωματωμένο στο GPS (Stats,Apex pro). Η διαδικασία αυτή επαναλήφθηκε σε 6 αγώνες. Για να ελεγχθεί η μεταβολή της επίδοσης μεταξύ των ομάδων ως προς τον χρόνο, χρησιμοποιήθηκε ανάλυση anova, με επαναλαμβανόμενες μετρήσεις. Στη συνέχεια για να ελεγχθεί η ομοιογένεια μεταξύ των ομάδων, στην αρχή, αλλά και για τις διαφορές μετά από την εφαρμογή των προγραμμάτων χρησιμοποιήθηκε independent t test, μεταξύ των ομάδων πειραματική και ελέγχου, ενώ μεταξύ των τριών ομάδων με τα διαφορετικά πρωτόκολλα πραγματοποιήθηκε αντίστοιχα Oneway Anova. Τέλος, πραγματοποιήθηκαν Paired T-Test των ομάδων ξεχωριστά πριν και μετά την εφαρμογή των προγραμμάτων αποκατάστασης. Η αξιολόγηση των δεδομένων πραγματοποιήθηκε µε το στατιστικό πακέτο SPSS 15. Το επίπεδο σημαντικότητας ορίσθηκε στο P≤0.05. Συμπερασματικά, οι ποδοσφαιριστές πρέπει να συμμετέχουν σε οργανωμένα προγράμματα αποκατάστασης κατά την αγωνιστική περίοδο. Στην παρούσα μελέτη βρέθηκε ότι το συγκεκριμένο πρωτόκολλο αερόβιας ασκήσεις χαμηλής έντασης με ποδηλασία την επόμενη ημέρα από τον αγώνα μπορεί να βοηθήσει στην διαδικασία της αποκατάστασης. Προτείνεται η διερεύνηση πρωτοκόλλων με συνδυαστικά προγράμματα ενεργητικής και παθητικής αποκατάστασης καθώς και προγράμματα με τεχνικό-τακτικό περιεχόμενο ασκήσεων.
O ρόλος των κλινικών επιδράσεων του IRL-1620 σε πειραματικό μοντέλο τραυματισμού του νωτιαίου μυελού
Authors: Μαυρίδης Θεόδωρος
Published: May 2024

Υπόβαθρο: Ο τραυματισμός του Νωτιαίου Μυελού (ΝΜ) αποτελεί μία σημαντική παγκόσμια πρόκληση για τη δημόσια υγεία, με αυξανόμενη επίπτωση και σημαντική αναπηρία. Παρόλο που έχει σημειωθεί πρόοδος στην κατανόηση της παθοφυσιολογίας και της πρώιμης διαχείρισης του τραυματισμού του ΝΜ, εξακολουθεί να υπάρχει έλλειψη αποτελεσματικών θεραπειών που να στοχεύουν στις μακροχρόνιες επιπλοκές. Η παρούσα μελέτη ερευνά τη δυνατότητα του sovateltide, ενός εκλεκτικού αγωνιστή του υποδοχέα B της ενδοθηλίνης (ETB), στη βελτίωση των κλινικών αποτελεσμάτων σε ένα πειραματικό μοντέλο τραυματισμού του ΝΜ σε αρουραίους. Μέθοδοι: Τριάντα αρσενικοί αρουραίοι Sprague-Dawley υποβλήθηκαν σε εικονικό χειρουργείο (Ομάδα Α) ή τραυματισμό του νωτιαίου μυελού (ΝΜ) και χορηγήθηκε με έκδοχο (Ομάδα Β) ή sovateltide (Ομάδα Γ). Οι κλινικές δοκιμασίες, συμπεριλαμβανομένων και της εκτίμησης κινητικότητας με την κλίμακα κατά Basso, Beattie, και Bresnahan (BBB) scoring, δοκιμασίας κεκλιμένου επιπέδου και έλεγχος αλλοδυνίας με ίνες Von Frey, πραγματοποιήθηκαν σε διάφορα χρονικά σημεία κατά τη διάρκεια του πειράματος. Στατιστικές αναλύσεις αξιολόγησαν τα αποτελέσματα της θεραπείας.Αποτελέσματα: Η χορήγηση sovateltide βελτίωσε σημαντικά την κινητική λειτουργία, μείωσε τα νευρολογικά ελλείμματα και ενίσχυσε την ανάκαμψη της κινητικότητας σε σύγκριση με τους αρουραίους όπου χορηγήθηκες εικονικό φάρμακο, ξεκινώντας από την 7η ημέρα μετά τον τραυματισμό. Επιπλέον, υπήρξε αύξηση του αλλοδυνικού ουδού, υποδηλώνοντας αναλγητικές ιδιότητες. Ειδικότερα, η ομάδα του sovateltide επέδειξε μια συνεχιζόμενη ανάκαμψη, φτάνοτνας ακόμα και στα κλινικά επίπεδα προ τραυματισμού, ενώ η ομάδα του εικονικού φαρμάκου παρουσίασε ένα κλινικό plateau, χωρίς περαιτέρω βελτίωση.Συμπεράσματα: Η μελέτη αυτή υποδηλώνει ότι το sovateltide μπορεί να ασκεί νευροπροστατευτικές δράσεις, ενισχύοντας τη νευρογένεση και την αγγειογένεση. Επιπλέον, μπορεί να έχει αντιφλεγμονώδεις και αναλγητικές ιδιότητες. Μελλοντικές κλινικές δοκιμές είναι απαραίτητες για να επικυρώσουν αυτά τα ευρήματα, αλλά το sovateltide δείχνει ένα πολλά υποσχόμενο μόριο ως θεραπευτική στρατηγική για τη βελτίωση των λειτουργικών ελλειμμάτων μετά από τραυματισμό του ΝΜ. Το sovateltide, ένας αγωνιστής του υποδοχέα ETB, επιδεικνύει νευροπροστατευτικές ιδιότητες, ενισχύοντας την κινητική ανάκαμψη και βελτιώνοντας την υπεραλγησία σε ένα μοντέλο τραυματισμού του ΝΜ σε αρουραίους. Αυτά τα ευρήματα μπορεί να ανοίξουν τον δρόμο για καινοτόμες φαρμακευτικές παρεμβάσεις για την αντιμετώπιση και τη θεραπεία του τραυματισμού του ΝΜ στην κλινική πράξη.
Case Report: Radiological diagnosis of atypical meningioma
Authors: Kumari Anjali , Mishra Gaurav V , Parihar Pratapsingh , Shinde Dhananjay , Dudhe Sakshi , Agrawal Rakshanda
Published: May 2024

Meningiomas are one of the most commonly occurring, extra-axial, primary tumors of central nervous system that are slow-growing in nature with a female predominance mostly occurring in the mid-late twenties. The clinical symptoms of atypical meningioma include headache, seizures, change in personality or behavior, development of a localized neurologic impairment, drowsiness, confusion, loss of hearing or tinnitus, fatigue on exertion, projectile vomiting and visual disturbances. If a meningioma is left untreated, it can cause problems such as loss of neurological function, weakness/numbness, hearing or vision loss, and balance problems. Sometimes there are worsening signs of persistent headaches, origin of new episodes of seizures, or increased intracranial pressure and neurological evaluation should be performed, followed by radiological studies if necessary. The best investigations for early diagnosis are CT and Magnetic Resonance Imaging scans (MRI). Total surgical excision of the tumor is the best management option for the neurological symptoms. In certain situations, such as atypical, malignant, or recurrent meningioma, radiation with a cumulative dose of 45-60 Gy is now employed There is a long-term re-occurrence rate of completely and incompletely resected atypical meningioma. Radiotherapy is beneficial in patients with low surgical risk, meningiomas in surgically inaccessible areas, and advanced age. Hormonal therapy and chemotherapy can be attempted when meningiomas are unresectable. In recurrent meningiomas, chemotherapy with hydroxyurea appears to be fairly active and has been mildly beneficial, as has hormonal therapy with progesterone antagonists. Thus, early diagnosis and management are essential to reduce neurological compromise and imprdaove the survival rate of patients with brain tumors.
Iodine density of lymphoma, metastatic SCCA, and normal cervical lymph nodes: Based on DLSCT
Authors: Mingkwansook Varalee , Wangprasertkul Urusaya , Tarathipmon Warit , Watcharakorn Arvemas
Published: May 2024

Objective To compare iodine density (ID) and contrast-enhanced attenuation value (CEAV) from dual-layer spectral computed tomography (DLSCT) scans of lymphomatous, metastatic squamous cell carcinoma (SCCA), and normal cervical lymph nodes. Methods Data including ID and CEAV were retrospectively collected from patients who underwent DLSCT of the neck between January 2020 and August 2023. Results from each group (lymphomatous, metastatic SCCA, and normal) were compared and analyzed using one-way ANOVA and receiver operating characteristic curve. Results 129 cervical lymph nodes were collected from patients who met the inclusion criteria (50, 41, and 38 nodes from the lymphomatous, metastatic SCCA, and normal group, respectively). The mean ID of lymphomatous, metastatic SCCA, and normal nodes was 1.01±0.27, 1.36±0.28, and 1.45±0.29 mg/mL, respectively. Comparing lymphomatous nodes with metastatic SCCA nodes, the lymphomatous nodes had significantly lower values of ID (p<0.002) and CEAV (p<0.001). Similarly, when comparing lymphomatous nodes with normal nodes, the lymphomatous nodes had significantly lower values of ID (p<0.001) and CEAV (p<0.001). The optimal ID cut-off value for distinguishing between lymphomatous and metastatic SCCA nodes was 1.175 mg/ml (specificity of 84.2%, sensitivity 77.8%, AUC 0.788, P = 0.003). The optimal CEAV cut-off value was 77.5 HU (specificity 88.9%, sensitivity 78.9%, AUC 0.851, P<0.001). Conclusions The ID and CEAV measurements from DLSCT were significantly different between lymphomatous, metastatic SCCA, and normal lymph nodes. These findings indicate that DLSCT can be used to distinguish between these conditions in the diagnosis of cervical lymph nodes.
Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic and macroscopic evaluation
Authors: Powantia Pontoh Ludwig Andribert , Fiolin Jessica , Dilogo Ismail Hadisoebroto , Prasetyo Marcel , Antarianto Radiana Dhewayani , Harahap Alida , Tantry Angela Jennifer , Pakasi Trevino Aristakus , Priosoeryanto Bambang Pontjo , Dewi Tri Isyani Tungga
Published: May 2024

Background Current treatment of osteoarthritis (OA) mainly focused on treating symptoms. Exosome from Adipose-derived Mesenchymal Stem Cell (Ad-MSC) have been shown to delay degenerative process. This study aimed to investigate the clinical, radiological and histological impact of combined intra-articular (IA) hyaluronic acid (HA) and exosome Ad-MSCs in-vivo using a larger animal model with low-grade OA. Methods Eighteen male Ovies aries sheep underwent total lateral meniscectomy and conventional radiography was performed to confirm low-grade OA after 6 weeks. The sheep were divided into three groups, Group 1 (G1; n=6) received thrice exosome injections, G2 (n=6) received twice HA injection, and G3 (n=6) received both treatments with a 1-week interval after 10 days of meniscectomy. Clinical evaluations were conducted using the Clinical Lameness Score (CLS), radiographic with X-ray using OA score by Innes et al, while macroscopic evaluation by Osteoarthritis Research Society International (OARSI) scores. Results Lameness parameter scored lowest in G3 significantly (2.0±0.0 VS 2.7±0.52 VS 2.7±0.52; p=0.024) at the second month although the overall CLS score did not significantly differ at the 3rd month. The best improvement of conventional total OA radiographic score at the 3rd month compared to all groups (5.2±1.17 vs 6.3±0.82 vs 6.7±1.03; p=0.053). Macroscopic OARSI evaluation showed no difference (p=0.711). Conclusions Combined repeated exosome Ad-MSC and HA IA injection proven to delay OA progression, however longer duration of follow up is required to evaluate its long-term effect.
Hypoglycemia impact on psychiatric symptoms and brain changes in anorexia nervosa
Authors: Zaroda Przemysław , Dąda Paweł , Pawlik Paweł , Niewinna Patrycja , Żuchowski Michał , Mańdziuk Dominika , Kołodziej Klaudia , Kołodziej Wojciech , Wawrzkowicz Jakub , Korga Monika
Published: May 2024

This study examines the potential impact of hypoglycemia on mental comorbidity in anorexia, comparing it to similar changes in diabetes. Anorexia, characterized by low body weight, is linked to hypoglycemia, possibly affecting mental health. Recurrent hypoglycemia in diabetes leads to mood changes and cognitive impairment. Anorexic individuals may experience deficits in cognitive functioning and psychiatric comorbidities, including affective disorders and anxiety. Imaging studies show structural changes in the brains of both anorexia and diabetes patients, but the direct link between hypoglycemia and psychoorganic changes in anorexia remains inconclusive, warranting further investigation.
Variability of the origin and course of the uterine artery in clinical practice
Authors: Sobolewska Adela , Gierulska Natalia , Stachowicz Hubert , Iwaniuk Kaja , Białkowska Zuzanna , Daniluk Aleksander , Ostański Jan , Buczek Jakub , Samczuk Maciej , Gawłowicz Łukasz
Published: May 2024

In 2020, approximately 287,000 mothers died during pregnancy or childbirth, with one of the leading causes of maternal mortality being peripartum hemorrhage. It can be treated both pharmacologically and procedurally, for example, through uterine artery ligation, embolization, or hysterectomy. In case of procedural treatment, it is essential for the medical team to familiarize themselves with the anatomical structure of the patient's uterine arteries. Various variations in the course of this vessel are distinguished, such as the uterine artery branching as a bifurcation with the inferior gluteal artery, a common trunk of the uterine artery with another vessel, or even its duplication. Using radiological techniques such as angiography, it is possible to visualize vessels and their variations, which can allow for better patient care. Unfamiliarity with the departure and trajectory of the uterine artery may be associated with an increased risk of postoperative complications, especially after hysterectomy, where the uterine arteries close at the level of the uterus or at the beginning of their departure from the internal iliac artery. Ligating them in other place may result in ischemia of an area that should be continuously supplied with blood. Also, during surgery, special attention should be paid to possible anatomical variations of the patient's uterine artery, which, although rare, can cause intraoperative complications. A thorough analysis of the departure and trajectory of the uterine artery by physicians can prevent postoperative complications and also allow for the safe conduct of embolization procedures. The following article presents a literature review on the departure and course of the uterine artery and its variations, as well as procedural interventions related to this vessel.
Metal toxicity exposure in Alzheimer's disease - literature review
Authors: Jakubowska Eliza , Hoppe-Mitera Ewa , Sionek Irena , Ślemp Julia , Pakuła Anita , Kuźma Krzysztof , Bierć Karolina , Grochowska Marcelina , Kisiel-Cybula Ewelina , Adamowicz Arleta
Published: May 2024

Introduction and purpose: As the elderly population grows, the risk of cognitive decline and dementia increases. Environmental toxicants, including metals, have been identified as potential contributors to these conditions. This literature review investigated the potential contribution of metals, such as aluminium, lead, zinc and copper to Alzheimer's disease development.Material and methods: The literature was conducted using "Pub Med" and "Google Scholar" databases with the keywords "metals", "Alzheimer's disease", "aluminium", "lead", "neurodegenerative diseases", "copper".Brief description of the state of knowledge: Metals can negatively affect the functionality of the central nervous system, leading to impairments in behavior, motor skills, and cognitive abilities. The development of Alzheimer's disease can be influenced by several factors, including Aβ aggregates, tau tangles, synaptic dysfunction, inflammation, and oxidative stress, which may be worsened by interactions with these metals.Results and conclusions: Extensive research has shown a link between metal exposure and neurodegeneration. Understanding the role of metals like lead, copper, aluminum, and zinc in Alzheimer's disease pathogenesis remains crucial, but further investigation is needed. A better insight into the impact of metal exposure on brain health could help find the way for effective prevention and treatment strategies for neurodegenerative diseases.
ERCP (endoscopic retrograde cholangiopancreatography) and EUS (endoscopic ultrasonography) in diagnosis of choledocholithiasis – battle or cooperation?
Authors: Szymkowicz Anna , Pałuchowska Julia , Sambura Maria , Rosołowska-Żak Sara , Paschke Patrycja , Miczek Igor
Published: May 2024

Introduction: Diagnosis of choledocholithiasis, a common manifestation of gallstone disease, is mainly based on advanced endoscopic techniques such as ERCP and EUS. Since the 1970s, ERCP has been a key method in the diagnosis and treatment of choledocholithiasis, allowing direct visualization and therapeutic interventions. However, technological developments have brought the emergence of EUS as a complementary tool, providing high-resolution imaging of the bile ducts. Understanding the diagnostic accuracy, therapeutic options and complications of both modalities is key to optimizing the care of patients with bile duct stones.
Aim of the study: The aim of our study is to review and compare various diagnostic methods of bile duct stones, as well as to assess their effectiveness, accuracy, and potential complications.
Materials and methods: We searched electronic sources, aspecially in the PubMed and Google Scholar databases, using keywords such as ,,endoscopic ultrasonography”, ,,endoscopic retrograde cholangiopancreatography” and ,,choledocholithiasis”.
Conclusions: With the use of modern technologies, such as endoscopic ultrasonography (EUS) and retrograde choleangiopancreatography (ERCP), it has become possible to diagnose bile duct stones more accurately and introduce more effective and less invasive therapies. The development of the availability of diagnostic tests, especially those that do not require invasive procedures, has helped reduce the risk of complications. EUS may be the preferred tool of choice for patients with gallstones, as it is associated with a lower risk of complications compared to ERCP alone. Decisions regarding the use of specific diagnostic and therapeutic modalities should be made on a case-by-case basis, taking into account medical and economic considerations.
Biological treatment options for severe asthma in Poland
Authors: Superson Maciej , Wilk-Trytko Klaudia , Szmyt Katarzyna , Samojedny Sylwia , Szymańska Katarzyna , Walczak Kamil , Krasnoborska Julia , Zarębska Julia
Published: May 2024

Intruduction and purpose: Patients with severe asthma account for approximately 3% to 10% of all asthma patients. They have higher hospital utilization rates and treatment costs than patients with non-severe asthma. Previously, treatment options for these patients were limited due to unacceptable side effects. However, the advent of biologic therapies has provided promising targeted therapy for these patients.
State of knowledge: Biologic therapies target inflammatory modulators that play a key role in the pathogenesis of asthma, particularly in patients with high T2 cells. These therapies have shown promising results in reducing asthma symptoms, improving lung function, decreasing the use of oral corticosteroids, and enhancing patients' quality of life.
Conclusions: This article reviews the mechanism of action, efficacy, and indications of currently approved biologic drugs available in Poland, as well as potential therapeutic targets for the future.
Metaanalysis of Public Wastewater Metagenomes: Revealing the Influence of Climatic Variations on the Abundance of the Bacterial Members
Authors: Karmakar Rupsha , Mondal Kaustav , Ghosh Mahashweta Mitra
Published: May 2024

As per the present trend, earth may experience severe hike in temperature by 2040. Therefore, global surveillance is required to combat against the upcoming climatic extremities. Emerging and re-emerging infectious diseases are part of the key pressing issues which can affect millions of people worldwide. Wastewater associated metagenomic data representing the wastewater samples collected from sewer networks in Newcastle (United Kingdom); Zimbabwe (Africa) and West Bengal (India), available in public databases were collected. It was observed that of the top 10 abundant genera, the prevalent genera in samples from United Kingdom, Africa, India were Desulfitobacterium, Prevotella, Sulfurospirillum respectively. By comparing all the three samples under study; it was observed that three microbial genera Bacteroides, Dechloromonas and Faecalibacterium were common throughout the samples. Metagenome-wide association studies were conducted to link microbes in the sample to the host disorders. Our study could predict overexpression of several enriched pathways like Vancomycin resistance, Platinum drug resistance across the samples. These findings prove efficacies of the community genomics approach to serve as a public health monitoring tool through detection of spatial variation as well as degree of commonness in wastewater bacterial profiles and also through the prediction of the pathogenic quantum of wastewater systems.
Contamination of Water by Heavy Metals and Treatment Methods – A Review
Authors: Suja S. K. , Almaas S , Gracy A Prasanna , Gowsika P , Jeyapradeepa K , Sri G Suba , Mathiya S , Asha K Berlin
Published: May 2024

Water is an indispensable need for the survival of living ecosystems. Industrialization and urbanization gifted a sophisticated life as well as a polluted environment. Water is getting polluted by various means like human activities, industries, and sewage. One of the serious issues around the globe in the upcoming days is heavy metal pollution. A voluminous amount of heavy metals are let into the environment from various sources like agricultural, industry, sewage, and mining. It causes adverse effects on the environment and human beings when the heavy metals concentration is beyond the expected permissible limit. Innovative processes are developing day by day for the operational deletion of heavy metals. This review article provides a consolidated report of the treatment techniques used for heavy metals removal of with excellent efficiency like precipitation, ion-exchange process, adsorption, solvent extraction, electrocoagulation and membrane processes.
Exploring Cost Effective Fleet Electrification Possibilities for Public Transit Services in Kutch Region
Authors: Prajapati Mamta L , Desai Nipa A.
Published: May 2024

The extensive use of fossil fuels in transit buses has led to both environmental problems and fuel scarcity. Renewable energy has emerged as a potential solution to mitigate these issues. Many countries worldwide have already adopted renewable energy to address these challenges. Similarly, the Indian government has initiated e-vehicle adoption in various sectors through subsidies to reduce dependence on conventional fuels. This research investigates two key areas: Fuel consumption dependency and air quality impact assessment for diesel-operated public buses (GSRTC) and Exploring fleet electrification possibilities. The recent significant rise in fossil fuel costs has exposed the inherent conflicts between achieving net-zero goals, ensuring energy security, and maintaining affordability. This research employs a three-stage energy modeling methodology: Route energy planning, charging infrastructure planning and total cost of ownership (TCO) analysis. This study explores the potential for fleet electrification at the Mundra depot, aiming to replace existing diesel-powered internal combustion engines (ICEs) with environmentally friendly electric vehicles (EVs). A total of 18 buses from the Mundra depot, covering 22routes with 103 trips, were surveyed. An optimal route requiring minimal energy was prioritized. Based on this and a minimum state-of-charge requirement of 25%, five buses were chosen for further study. An analysis of annual capital costs for both ICE diesel and electric buses was conducted, considering bus capitalization, battery capitalization, charging infrastructure, and annual operation costs. The findings revealed that the TCO for an EV bus is significantly lower than that of a diesel bus (49.64 Rs/km vs. 72.80 Rs/km).
Identification of cell-specific epigenetic patterns associated with chondroitin sulfate treatment response in an endemic arthritis, Kashin-Beck disease
Authors: Cheng Bolun , Wu Cuiyan , Wei Wenming , Niu Hui , Wen Yan , Li Cheng , Chen Ping , Chang Hong , Yang Zhengjun , Zhang Feng
Published: May 2024

Aims

To assess the alterations in cell-specific DNA methylation associated with chondroitin sulphate response using peripheral blood collected from Kashin-Beck disease (KBD) patients before initiation of chondroitin sulphate treatment.

Methods

Peripheral blood samples were collected from KBD patients at baseline of chondroitin sulphate treatment. Methylation profiles were generated using reduced representation bisulphite sequencing (RRBS) from peripheral blood. Differentially methylated regions (DMRs) were identified using MethylKit, while DMR-related genes were defined as those annotated to the gene body or 2.2-kilobase upstream regions of DMRs. Selected DMR-related genes were further validated by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to assess expression levels. Tensor composition analysis was performed to identify cell-specific differential DNA methylation from bulk tissue.

Results

This study revealed 21,060 hypermethylated and 44,472 hypomethylated DMRs, and 13,194 hypermethylated and 22,448 hypomethylated CpG islands for differential global methylation for chondroitin sulphate treatment response. A total of 12,666 DMR-related genes containing DMRs were identified in their promoter regions, such as CHL1 (false discovery rate (FDR) = 2.11 × 10-11), RIC8A (FDR = 7.05 × 10-4), and SOX12 (FDR = 1.43 × 10-3). Additionally, RIC8A and CHL1 were hypermethylated in responders, while SOX12 was hypomethylated in responders, all showing decreased gene expression. The patterns of cell-specific differential global methylation associated with chondroitin sulphate response were observed. Specifically, we found that DMRs located in TESPA1 and ATP11A exhibited differential DNA methylation between responders and non-responders in granulocytes, monocytes, and B cells.

Conclusion

Our study identified cell-specific changes in DNA methylation associated with chondroitin sulphate response in KBD patients.

Cite this article: Bone Joint Res 2024;13(5):237–246.
Sensory Patterns of Children with Williams Syndrome
Authors: Huri Meral , Kars Sinem , Şahin Sedef , Pekçetin Serkan , Mehr Babak Kashefi
Published: May 2024

Aim: Williams syndrome is a neurodevelopmental disorder caused by a deletion on chromosome 7. It is characterized by a range of medical problems in addition to the demonstration of maladaptive emotional and physical responses to environmental stimuli. Furthermore, sensory processing abnormalities are common in children with Williams syndrome. Therefore, this study aimed to report sensory processing difficulties in children with Williams syndrome in Turkey. Methods: Twenty-three children with Williams syndrome (mean age 63.16±13.50 months; females n=13) and twenty-two typically developing children (mean age 67.66±13.23 months; females n=12) were included. Parents completed the Sensory Profile Questionnaire. Data were analysed using descriptive statistics and the Mann‒Whitney U test. Results: Children with Williams syndrome demonstrated sensory processing dysfunction in the sensory processing, modulation, behaviour and emotional response areas. Moreover, they have difficulties in low registration, sensation seeking, sensory sensitivity, sensation avoiding, sensory seeking, emotionally reactive low endurance/tone, oral sensitivity, inattention/distractibility, poor registration, sedentary behaviours, and fine motor/perceptual skills factors compared to their typically developing peers. Conclusions: These findings, considered with similar published studies, confirm the prevalence and types of sensory processing abnormalities in Williams syndrome.
Podološka analiza djece s motoričkim poremećajima (20 slučajeva) – naša iskustva
Authors: Mansi Zied , Aymen Ben Mahmoud , Tounsi Abdelkader , Mahmoudi Ahmed , Chermiti Wajdi , Haggui Ali , Bacem Zaidi
Published: May 2024

Introduction and Importance: Pediatric patients with neuromotor disorders frequently experience various podiatric conditions. The effectiveness and implications of treatments like orthotics and insoles in this demographic are not thoroughly understood, highlighting a significant gap in podiatric research and clinical practice. Case Presentation: This observational study analyzed 20 pediatric patients with neuromotor disorders. The focus was on common foot conditions such as ingrown toenails and hyperhidrosis, and their association with treatments like orthotics, insoles, and surgical interventions like Achilles tendon lengthening. Clinical Discussion: Statistical analysis using chi-square tests revealed significant associations. Notably, orthotic use was linked to a higher incidence of ingrown toenails (χ² = 5.69, p = 0.017). In contrast, insole usage correlated with increased hyperhidrosis (χ² = 4.44, p = 0.035). Additionally, a significant tendency for orthotic use was observed in patients who underwent Achilles tendon lengthening (χ² = 8.15, p = 0.017). The study also highlighted the prevalence of brittle nails and hyperkeratosis among the participants. Conclusion: The findings emphasize the critical role of podiatrists in the management of foot conditions in pediatric neuromotor disorder patients. While interventions like orthotics are generally beneficial, they may also exacerbate or contribute to other conditions, necessitating regular and careful podiatric monitoring. The study advocates for future research with larger sample sizes and controlled study designs to further validate and expand upon these observations.
An Alternative Method of Assessing d/DHH Secondary-School Students' L2 Language Development
Authors: Lee Jongwoo , Son Myeongeun , Lee Jongbong
Published: May 2024

Abstract: Little information is available on d/Deaf and hard of hearing (d/DHH) learners' L2 development. Their limited auditory access may discourage them from taking standardized tests, highlighting the need for alternative ways of assessing their L2 development and proficiency. Therefore, this study suggests adopting processability theory, which demonstrates a universal order of L2 development. Interviews with d/DHH learners and their teachers were conducted to explore their current difficulties in regard to understanding their L2 development. Also, we conducted brief speaking tasks to suggest alternatives to testing the L2 development of learners who are d/DHH in comparison to typical literacy learners. The result showed d/DHH students' L2 developmental patterns are similar to those of typical hearing peers, suggesting that d/DHH students and hearing learners share difficulties in similar areas when learning English. Teachers highlighted the lack of appropriate English tests to determine the d/DHH students' L2 development.
Examining the Language and Communication Factors of a Deaf Child with Autism Spectrum Disorder from an Immigrant Korean Family
Authors: Kwon Eun Young , Cannon Joanna E. , Guardino Caroline
Published: May 2024

Abstract: Extant research on learners who are d/Deaf or hard of hearing with disabilities who come from Asian immigrant families is extremely sparse. The authors conducted an intrinsic case study of a deaf student with autism who comes from a Korean immigrant family. To acquire a comprehensive understanding of language and communication characteristics, they analyzed (a) interview data of three administrators who worked with the student and family and (b) school documents/reports issued to the parents. Themes are reported across the three components of the tri-focus framework (Siegel-Causey & Bashinski, 1997): the learner, partner, and environment. Implications for practitioners who work with these learners and their families are discussed, including (a) compiling an individualized language and communication profile that encompasses the framework; (b) utilizing culturally and linguistically responsive practices with the family; (c) practicing interprofessional collaboration; and (d) modifying physical and social environments to increase accessibility.
Deaf on the Prairie: Combining Traditional and Contemporary Learning Theories
Authors: Pedersen Holly F. , Holmen Lynae
Published: May 2024

Abstract: This single case study concerns an 11-year-old girl, Agata, who recently moved to a rural community in the United States from the Philippines. Agata is profoundly deaf, has had no access to amplification, and has had very limited access to language and formal school. The journey through the next year, including the COVID-19 pandemic, saw Agata's language and literacy skills blossom at an unexpected rate. The study examines the how and why of Agata's progress by using multiple sources of both quantitative and qualitative data. A conceptual framework of both direct instruction theory (Engelmann & Carnine, 1982) and resilience theory (Garmezy, 1993) was used to systematically analyze the factors that contributed to Agata's growth and offer a more thorough understanding of the complex challenges and potential successes in supporting students from Asian communities who are d/Deaf or hard of hearing (d/DHH).
Afterlives of Ottoman Orphans in Germany during World War I: Microhistorical and Biographical Approaches to Technology, Expertise, and Labor in Turkey
Authors: Maksudyan Nazan
Published: May 2024

ABSTRACT: This article applies a (micro)biographical approach to the life stories of two Ottoman orphans sent to Germany to receive vocational training during World War I, Ali and İsmail Dağlı. Coupling family archives, oral and visual sources with state documentation, I elaborate on the post-Ottoman afterlives of German know-how, education, and capital in the social and economic history of Turkey. Biographies of Dağlı brothers show that the successors of both empires restored former channels of circulation of expertise, technology, and labor. Especially seen in the context of Jewish emigration, the life and work history of the brothers elucidate the positive reception of their German education, the importance of their position as “cultural intermediaries,” and the extent of Turkish-German business entanglements.
“The Desire for Peace is ‘Unconstitutional’ in Bonn”: The Free German Youth and Rearmament in West Germany, 1945–1952
Authors: Puaca Brian M.
Published: May 2024

ABSTRACT: Best known as the state youth organization of the German Democratic Republic, the Free German Youth (FDJ) operated widely in West Germany during the early Cold War era. This article provides a brief history of the West-FDJ, as it was known, and concentrates on its prominent efforts challenging Chancellor Konrad Adenauer’s rearmament policies in the early 1950s. While the decision to ban the organization in 1951 was justified by concerns about the fragility of the young democratic state, the Adenauer government’s strident response also served as a politically expedient strategy to undermine resistance to West Germany’s remilitarization.
Background-free imaging of cold atoms in optical traps
Authors: Li Li , Liu Yijia , Zhou Xiaolong , Huang Dongyu , Shen Zemin , He Sijian , Wang Jian , Li Chuanfeng , Guo Guangcan
Published: May 2024

Optical traps, including those used in atomic physics, cold chemistry, and quantum science, are widely used in the research on cold atoms and molecules. Owing to their microscopic structure and excellent operational capability, optical traps have been proposed for cold atom experiments involving complex physical systems, which generally induce violent background scattering. In this study, using a background-free imaging scheme in cavity quantum electrodynamics systems, a cold atomic ensemble was accurately prepared below a fiber cavity and loaded into an optical trap for transfer into the cavity. By satisfying the demanding requirements for the background-free imaging scheme in optical traps, cold atoms in an optical trap were detected with a high signal-to-noise ratio while maintaining atomic loading. The cold atoms were then transferred into the fiber cavity using an optical trap, and the vacuum Rabi splitting was measured, facilitating relevant research on cavity quantum electrodynamics. This method can be extended to related experiments involving cold atoms and molecules in complex physical systems using optical traps.