bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract
Authors: Afra Fairuz Yaumil , Soeratri Widji , Purwanto Djoko Agus
Published: December 2022

Background: The addition of alpha-lipoic acid in Nanostructured Lipid Carrier-Green Tea Extract (NLC-GTE) has potential to increase effectiveness of anti-aging preparations. It happened because alpha-lipoic acid can increase stability and antioxidant activity. Objective: Comparing the physical characteristics and stability of NLC-GTE with or without alpha-lipoic acid. Methods: NLC-GTE manufactured using the High Shear Homogenization method. NLC-GTE was divided into two formulas, without the addition of alpha-lipoic acid for F1 and with the addition of alpha-lipoic acid for F2. The characteristics and physical stability were tested, including organoleptic, pH, particle size, and polydispersity index. Stability test was held using the thermal cycling method. Results: Based on characteristic test, it was found that F2 had larger particle size value than F1. The average particle size value of F1 is 313.9 ± 0.76 nm and 423.4 ± 0.75 nm for F2. The F1 and F2 preparations had a polydispersity index value below 0.3, so they were homogeneous. The average pH value of F1 is 5.998 ± 0.01, and F2 is 4.798 ± 0.004. The physical stability test showed a difference before and after the sixth day in particle size and pH, but it was still in the range, so it was safe. However, there was a separation in F1 after day 6. Conclusion: Based on the characteristics and physical stability tests, F1 (without alpha-lipoic acid) and F2 (with alpha-lipoic acid) had differences in particle size and pH. From the physical stability test, it can be concluded that F2 is more stable than F1.
Optimization Method and Stability Test to Determinate Luteolin, Quercetin, Apigenin, and Sinensetin Levels in Herbal Medicines Using TLC-Densitometry
Authors: Hidayatullah Muhammad , Yuwono Mochammad , Primaharinastiti Riesta
Published: December 2022

Background: Nephrolithiasis is a condition in which there are one or more kidney stones in the pelvis or calyces. Luteolin, quercetin, apigenin, and sinensetin are marker compounds in the extracts of Plantago major, Sonchus arvensis, Strobilanthes crispus and Orthosiphon stamineus which have nephrolithiasis activity. To control the quality of herbal medicines, a TLC-Densitometry method was developed in this study using luteolin, quercetin, apigenin, and sinensetin as phytochemical markers. Objective: The present work aimed to develop optimal conditions for analyzing luteolin, quercetin, apigenin, and sinensetin. Methods: Determination of optimal conditions for analysis is carried out by determining the composition of the mobile phase, chamber saturation time, and analysis wavelength. Silica gel 60 F254 was used as the stationary phase. Stability tests were carried out by analyzing standards and samples at 0, 4, 8, and 24 hours. Results: The best separation that produces symmetrical peaks of herbal medicine was achieved under isocratic conditions using the composition of the mobile phase chloroform : acetone: dichloromethane : acetonitrile : formic acid (6 : 2: 2 : 0,05 : 0.05 v/v/v/v/ v) with a wavelength of 335 nm with a saturation time of 30 minutes. Conclusion: In this study, the optimal conditions for the analysis of luteolin, quercetin, apigenin, and sinensetin. Luteolin, quercetin, apigenin, and sinensetin are unstable during 8 hours of storage. Therefore, standard solutions and samples must be made fresh to maintain stability.
The Effect of Insulin Administration on Medication Adherence in Type 2 Diabetes Mellitus Patients with Neurological Complications
Authors: July  , Sauriasari Rani , Syafhan Nadia Farhanah , Tahir Hadijah
Published: December 2022

Background: Medication adherence is essential to achieving controlled blood sugar in diabetic patients. Insulin generally provides better glycemic control but is considered painful and requires special techniques. Insulin administration in patients with neurological complications requires particular consideration because these complications can cause physical and cognitive barriers. Objective: This study analyses the effect of insulin administration on medication adherence in diabetic patients with neurological complications and the influence of various confounding variables (baseline characteristics, medical and medication history). Methods: This observational study was conducted with a cross-sectional design at a government hospital in East Jakarta from September 2021 to January 2022. The sample was type 2 diabetes mellitus patients with neurological complications who received antidiabetics for at least six months. The neurological complications include central nervous disorders (such as stroke) and peripheral nervous disorders (such as neuropathy). The independent variable was insulin administration, while the dependent variable was adherence, measured using subjective methods [Adherence to Refills and Medications Scale (ARMS)] and objective methods (Medication Refill Adherence (MRA) and HbA1c]. Results: Of 175 respondents, based on the three methods (MRA, ARMS, HbA1c), 13 respondents (7.4%) were adherent, namely one respondent (1.8%) in the insulin group and 12 respondents (10.1%) in the non-insulin group. Insulin administration affects adherence to antidiabetics by 0.123 times (95% CI: 0.015 - 1.024), or patients who use insulin have 87.7% lower adherence controlled by antidiabetic changes and the total number of medicines used. Conclusion: Insulin administration significantly affects medication adherence in diabetes mellitus patients with neurological complications.
The Influence of Feeling Lonely and Received Social Support on Medication Adherence in Elderly with Hypertension
Authors: Dwi Novita Sari  , Wahyu Utami  , Elida Zairina
Published: December 2022

Background: Hypertension is currently a non-contagious disease that primarily affects the elderly population in Indonesia. Medication adherence is critical in managing hypertension and reducing the risk of morbidity and mortality. Previous research has found that loneliness and support received by older adults with hypertension influence medication adherence. Objective: This study aimed to examine the impact of feeling lonely and receiving social support on medication adherence in the elderly with hypertension at the Community Health Center in Surabaya. Methods: The study design of this research was a descriptive cross-sectional study from December 2021 to March 2022. A total of 235 eligible subjects fulfilled the inclusion criteria. The instruments used in the data collection were the patient's information form, UCLA-Loneliness Scale, MOS-Social Support Survey, and the ARMS (Adherence to Refill and Medication Scale). Results: The results revealed that the correlation between loneliness and social support was significantly associated with medication adherence in the elderly with hypertension (p < 0.05). In addition,  other factors, such as occupation status, living status, comorbidity, the number of drugs taken, and antihypertensive drug therapy, showed a significant correlation with medication adherence (p < 0,05). The most influential factor on medication adherence was loneliness (35.5%), followed by social support (24.4%), the number of drugs taken (7.1%), antihypertensive drug therapy (monotherapy or combination therapy (2.5%), occupation status (2.4%), comorbidity (1.6%), and living status (0.2%). Conclusion: This study confirms that feeling lonely and receiving social support affect medication adherence in the elderly with hypertension at the Community Health Center in Surabaya.
Sunscreen Cream Formulation of Noni Leaf Extract (Morinda citrifolia L.) with Emulsifier Combination of Tween 80 and Lecithin
Authors: Tania Bianca Levie , Dwiastuti Rini , Lestari Agatha Budi Susiana , Setyaningsih Dewi
Published: December 2022

Background: Noni leaf (Morinda citrifolia L.) extract is a natural product that can be used as a sunscreen. The extract contains flavonoids which function act as an antioxidant. In this work, sunscreen cream formulated with noni leaf extract was prepared using a combination of tween 80 and lecithin. Objective: The purpose of this study is to evaluate how the combination of tween 80 and lecithin affects the physical qualities of the cream, such as organoleptic, homogeneity, emulsion type, spreadability, adhesion, pH, and stability over 28 days of storage at room temperature, and to find the best formula. Methods: This study used 10% of noni leaf extract in the cream formulation. The Simplex Lattice Design (SLD) method was used to determine the effect of different concentrations of the two emulsifiers on the cream's spreadability, adhesion, and pH. Furthermore, the SLD was used to find the best formula. Results: The results showed that different concentrations of the emulsifier, which are the tween 80 and lecithin combination, affected the physical properties and storage stability of cream preparations. The interaction of tween 80 and lecithin is having a significant impact on the cream's adhesion and spreadability; however, the effect of the interaction on the pH value was not significant. Conclusion: The formula containing 2.5 % tween 80 and 2.5 percent lecithin was found to be the most effective in fulfilling the cream physical properties while remaining stable during storage.
ADOPTION OF ISLAMIC BANKING IN FINANCIAL SATISFACTION : STUDY ON BANK SYARIAH INDONESIA YOGYAKARTA REGION
Authors: Kristanto HC Heru
Published: December 2022

The main purpose of this study was to examine the effect of Islamic financial literacy, religiosity, bankreputation, and risk attitude on the adoption of Islamic banking. Examine the mediating role of the adoption ofIslamic banking on the influence of Islamic financial literacy, religiosity, bank reputation, and risk attitude onfinancial satisfaction. The statistical analysis model used mediation regression. The research population was1.033.264 and the sample was 336 Bank Syariah Indonesia customers in the Jogjakarta region. The samplingtechnique used was random sampling, a data collection method using a questionnaire. The mediationregression analysis tool uses SEM-PLS. The results show that: Islamic financial literacy has a positive effecton the adoption of Islamic banking products. Bank reputation has a positive effect on the adoption of Islamicbanking. Religiosity has a positive effect adoption of Islamic banking. The risk attitude affects the adoption ofIslamic banking. Adoption of Islamic banking mediates the effect of Islamic financial literacy, bankreputation, religiosity, and risk attitude on financial satisfaction. The results of the study add to the literatureand the results of empirical studies of Islamic financial management. Provide recommendations for IslamicBank policies, namely: policies to increase Islamic financial literacy, bank reputation, risk attitude, adoption ofIslamic banking, and financial satisfaction to improve the welfare and performance of the bank.
False or Fake Qualifications in an Employment Context: A South African Perspective
Authors: Ndlovu Lonias , Leslie Andrew Brian
Published: December 2022

The pressure for employment opportunities has led to many dishonest practices by employees and job seekers. The evil of employees misrepresenting their academic qualifications has become endemic, and the South African government has been compelled to act. Misrepresentation of academic qualifications mainly manifests itself through employees claiming to have non-existent higher education qualifications to secure a new job offer or be promoted to a higher post. This misrepresentation has consequences for the employer, who may pay the employee a salary they do not deserve. The employee must refund the employer and face prospects of imprisonment if found guilty in a criminal court. In South Africa, high-profile individuals working in the public service or occupying prominent political positions have falsely claimed to have qualifications that they did not have. They have been allowed to resign on their own accord or were dismissed after lengthy disciplinary hearings. This paper outlines some examples of this misrepresentation and unravels the legal implications from a South African perspective. We recommend that employers promptly discipline employees found guilty rather than allow them to resign, as was done correctly in the Mthikhulu case discussed here. Further, we urge employers in South Africa to foreground the skills of employees rather than paper qualifications and assess technical ability ahead of academic qualifications.
The Fundamental Right for a Balanced Environment
Authors: Bertoldi Márcia , Massaú Guilherme
Published: December 2022

This paper reflects on the fundamental duty, extracted from art 225, caput, of the Brazilian Constitution, to protect and defend the environment. It refers to the duty arising from the fundamental right to an ecologically balanced environment. As it is a fundamental right, it defends the existence of a corresponding duty, in this case, a fundamental duty. Such a fundamental duty involves the relationship between present and future generations. The present generation must maintain and protect existing natural resources so the future generation may also enjoy the same natural resources. To reach the proposed objective, this paper adopts a deductive approach, has a qualitative character and uses the bibliographical-documentary procedure for its development. It concludes that the duty provided for in art 225, caput, is not enforceable by itself because it lacks efficacy; however, the right and duty to and with the environment are associated constitutional categories that become effective in return.
Israeli Territorial Annexation in Occupied Palestinian Territory: The Ambivalence of International Law
Authors: Aasi Joni
Published: December 2022

The enactment of Israeli policy on the occupied Palestinian territory has shown the development of the annexation of Israel—from the “de facto” annexation, which seized and occupied the Palestinian territory, to “de jure” annexation by enacting legislations. The dispute between these two entities arises the question of the role of international law, including the position of international law in protecting the right to self-determination and sovereignty of the annexed Palestinian territory. Hence, it is crucial to understand the Israeli practice in the matter of territorial annexation to picture the legal framework provided under international law regarding such issue, within the historical and legal context of the Palestinian case. This research argues that the international law is ambivalent. While many United Nations resolutions and legal scholars, including the advisory opinion of the International Court of Justice, have concluded the wrongfulness of the annexation of the Palestinian territory, the recognitions of other states and the difficulty in requesting state responsibility disable the access of Palestinians to justice. As such, it is necessary to focus on the tools provided by the international criminal law to prosecute war criminals and perpetrators of crimes against humanity against the Palestinian people from the Israeli political and military elites.
Optimization of Cash Waqf Linked Sukuk (CWLS) for supporting Indonesia’s economic recovery post-Covid-19 era
Authors: Sulaeman Sulaeman , Zubaidah Siti , Nur’atikah Tika
Published: December 2022

Purpose – The purpose of this study is to analyze the optimization of the Cash Waqf Linked Sukuk (CWLS) issuance mechanism and its potential to support Indonesia's economic recovery after the Covid-19 pandemic.Methodology – This study uses a qualitative descriptive analysis approach by exploring the relevant literature. This study also uses the SWOT (Strength, Weakness, Opportunity, and Threat) to obtain information on internal and external factors that can support and inhibit the planned issuance of CWLS.Findings – This study found that the investment returns from cash waqf funds in the CWLS model can be utilized for social and economic development in Indonesia. In line with the objectives of Indonesia's economic recovery program, namely: aiming to protect, maintain, and improve the economic capacity of business actors, especially MSMEs, in running their business during and after the Covid-19 pandemic in Indonesia.Implications – The CWLS model is expected to make a positive contribution to the Indonesian government and policymakers as material for further study of Islamic financing instruments, which can optimize their role in supporting the financing of Indonesia's economic recovery programs during and after the Covid-19 pandemic.Originality – The novelty of this research is proposing an alternative source of financing for the government in supporting Indonesia’s economic recovery. Further, this research contributes to the existing literature on Islamic social finance, especially for waqf studies.
The Effect of Gracilaria verrucosa Seaweed Flour Proportion with White Glutinous Rice Flour (Oryza sativa Glutinosa) and CMC (Carboxy Methyl Cellulose) Concentration on Physical and Chemical Characteristics of Seaweed Dodol
Authors: Elfahira Dieo Riezma , Hudi Lukman , Nurbaya Syarifa Ramadhani
Published: December 2022

Gracillaria verrucosa seaweed is one type of agar-producing red algae (agarophyte) that has the potential to be developed because it can be cultivated in polyculture in ponds together with shrimp and crab rearing.  Gracillaria verrucosa seaweed is usually used as a raw material for making gelatin, but it would be better to develop it in its processing so that it can produce products that have better economic value and nutritional value by utilizing Gracillaria verrucosa seaweed, and one of these preparations is dodol.  This study used factorial RAK (Randomized Block Design) which was repeated 3 times, with the first factor being the proportion of Gracilaria verrucosa seaweed flour with white glutinous rice flour (P) 75%: 25%, 50%: 50%, and 25%:  75%.  The second factor is the concentration of CMC (K) 2%, 4%, and 6%.  The data were analyzed using analysis of variance and then continued with the BNJ test (Honest Significant Difference) at 5% level. The best treatment was obtained in the P3K3 treatment (the proportion of Gracilaria verrucosa seaweed flour with white glutinous rice flour 75%: 25% and CMC concentration 6%) with  color profile L (lightness) 43.1;  color profile *a (redness) 4.9;  color profile *b (yellowness) 10.6;  1.66N texture water content 37.40%;  free fatty acid content of 0.28%;  reducing sugar content 0.4%;  antioxidant activity 368.6 g/ml.
The Experiences of Social Scientists in Medical Education Research: A Narrative Inquiry
Authors: Kang Nia , McMurtry Angus , Moreau Katherine
Published: December 2022

Although medical education research (MER) has been gaining recognition as an important area of research, the need for a social sciences perspective in such research is not always well understood. Available literature on the career progression of researchers in MER - with regards to factors like academic promotion and job satisfaction - have been largely limited to clinician or biomedical researchers. Thus, this narrative study aimed to explore and describe the experiences of social scientists developing careers within MER units housed in Canadian medical schools. It included semi-structured interviews with six faculty members of MER units in three Canadian medical departments. The data was then thematically analyzed, revealing the following themes: 1) challenges are systematic in nature but rewards tend to be interpersonal; 2) the development of MER units have helped improve social scientists’ experiences in MER; 3) interdisciplinary and interprofessional interactions act as both the greatest challenge and reward of a social scientist’s career in MER; 4) social scientists’ perceived experiences in MER are influenced by their perceived impact on institutional change; and 5) social scientists in MER retain and advocate for their identity as social scientists, but individual differences exist in the perceived gratification of advocacy work. The findings suggest the need for more interprofessional collaborations within and outside of MER to support systematic change in favour of an inclusive research environment, especially in departmental leadership and decision-making roles. Furthermore, there is a pressing need to implement standards within medical departments to recognize the contributions of social scientists to knowledge translation and mentorship.
Factors influencing abortion decision-making of adolescents and young women: A narrative scoping review
Authors: Koiwa Yui , Shishido Eri , Horiuchi Shigeko
Published: December 2022

Introduction: Globally, about half of all induced abortions have been estimated to be unsafe, and have resulted in maternal death. Of these, 41% unsafe abortions have been reported in young women who are dependent on their parents for livelihood. They are often left in a vulnerable position and may have difficulty in making a decision regarding abortion. This study aimed to (a) characterize and map factors that influence abortion decision-making of adolescents and young women, and (b) identify the care and support they need in their decision-making process.
Methods: We conducted a scoping review following the JBI method and PRISMA-ScR checklist. We comprehensively searched MEDLINE (PubMed), EMBASE, Cochrane Library, CINAHL, and PsycINFO, and hand searched publications in Google Scholar database between November 2021 and December 2021. The search included all English language qualitative and mixed-methods research articles published from 1976 to November 2021, and included participants aged 10-24 years. The CASP checklist was used as guide for the qualitative analysis. Nvivo was used to synthesize the findings. Results: There were 14 studies from 10 countries (N = 334 young women) that met the inclusion criteria. Three domains and 11 categories were included: Personal (Desire for self-realization and Unwanted pregnancy), Interpersonal (Parental impact, Reaction of partner, Roles of peers and friends, Existence of own child, and Lack of support), and Social circumstances (Sexual crime, Financial problem, Limitation of choice, and Underutilized healthcare services). Decision-making factors regarding abortions were also found across all three domains.
Conclusion: The abortion decision-making of young women is influenced by various external factors regardless of country. Parents are especially influential and tend to force their daughters to make a decision. Young women experienced suffering, frustration, and lack of autonomy in making decisions based on their preference. This emphasizes the importance of autonomous decision-making. In this regard, healthcare services should be used. However, there are barriers to access these services. To improve such access, the following are required: staff training to provide women-centered care, counseling based on women’s needs, counseling including parents or guardians that is confidential and ethical, promotion of decision aids, and affordable accessible care.
Ultradurability of metastable β-Fe2O3 photoanodes in highly corrosive seawater
Authors: Liu Changhao , Zhang Ningsi , Li Yang , Fan Rongli , Wang Wenjing , Feng Jianyong , Liu C. , Wang Jiaou , Hao Weichang , Li Zhaosheng , Zou Zhigang
Published: December 2022

Durability is one prerequisite for material application. Photoelectrochemical (PEC) decomposition of seawater is a promising approach to produce clean hydrogen by using solar energy, but it always suffers from serious Cl− corrosion. We found that the main deactivation mechanism of the photoanodes is oxide surface reconstruction accompanied by the coordination of Cl− during seawater splitting, and the stability of the photoanodes can be greatly improved by enhancing the metal-oxygen interaction. Taking the metastable β-Fe2O3 photoanode as an example, Sn added to the lattice can enhance the M–O bonding energy and hinder the transfer of protons to lattice oxygen, thereby inhibiting excessive surface hydration and Cl− coordination. Therefore, the Sn/β-Fe2O3 photoanode without any extra electrocatalyst or protective overlayer delivered a record durability for PEC seawater splitting over 1440 h.
AI/ML driven intrusion detection framework for IoT-enabled cold storage monitoring system
Authors: Prasad Mahendra , Pal Pankaj , Tripathi Sachin , Dahal Keshav
Published: December 2022

An IoT-based monitoring system remotely controls and manages intelligent environments. Deployed sensors communicate themselves and transmit data over wireless communication. A sensor node (insider or outsider) is in the communication range, which can send data to other nodes. Due to such nature, it is more vulnerable to intrusions or attacks. Traditional (threshold based) is not powerful enough to detect intrusions, it shows low detection accuracy. An intrusion detection system is an efficient mechanism to detect malicious traffics and prevents abnormal activities. This paper suggests an intrusion detection framework for the cold storage monitoring system. In this, the temperature affects the environment and harms stored products. A malicious node work as a false data injection attack that manipulates temperature and forwards manipulated data, whereas a flooding attack disturbs the existing network. To handle these attacks, a dataset is generated and collected for training the machine learning techniques. Two machine learning techniques have applied as supervised learning (Bayesian Rough Set) and unsupervised learning (micro-clustering). These intrusion detection methods perform better and show high performance. Moreover, this work also provides the comparative analysis of the generated dataset to other IDS datasets.
Analysis of the Relationship between Knowledge, Behavior, Prevention, and Self-Efficacy of Professional Soccer Athletes on Mental Health During the COVID-19 Pandemic
Authors: Amiq Fahrial , Setijono Hari , Nurhasan Nurhasan , Inayatilah Fidia Rizkiah , Ayubi Novadri , Aljunaid Mohammed , Callixte Cyuzuzo
Published: December 2022

Background: The purpose of this study was to examine the relationship between knowledge, preventive behavior, and self-efficacy on mental health in professional football athletes during the Covid-19 pandemic.
Methods: This research uses quantitative methods. This type of research is observational with a cross sectional approach. In this study, researchers will take data on the dependent variable and the independent variable at the same time. This research was conducted by distributing a questionnaire consisting of 4 parts, namely a knowledge level questionnaire sheet, a preventive behavior questionnaire sheet, a self-efficacy questionnaire sheet, and a mental health questionnaire sheet.
Resultts: Based on the results of research on knowledge about covid-19, the majority of respondents, namely 44 people (55%) had a good level of knowledge related to COVID 19, 30 people (37.5%) had sufficient knowledge and only 6 people (7.5%) who have a low level of knowledge. While knowledge of preventive behavior, the majority of respondents 44 people (55%) have a good level of preventive behavior against covid-19, 33 people (41.25%) are sufficient and 3 people (3.75%) are lacking. Then knowledge about mental health, all respondents (100%) have normal mental health and no respondents are included in the category of anxiety disorders. While the results of self-efficacy, the average self-efficacy score of respondents was 4.28. The average score of 4.28 shows that the respondents' confidence in preventing the transmission of COVID-19 during the pandemic is quite high, although it has not yet reached the highest score.
Conclusion: Based on the results of the study, it can be concluded that there is a significant relationship between self-efficacy and the mental health of the respondents.
Subcutaneous immunoglobulin replacement therapy in patients with immunodeficiencies – impact of drug packaging and administration method on patient-reported outcomes
Authors: Mallick R. , Solomon G. , Bassett P. , Zhang X. , Patel P. , Lepeshkina O.
Published: December 2022

Background:Understanding the impact of subcutaneous immunoglobulin (SCIg) packaging (vials and pre-filled syringes [PFS]) and administration methods (pump and manual push) upon treatment experience can potentially facilitate optimization of patient outcomes. Here, the perspective of patients with primary and secondary immunodeficiency receiving SCIg was evaluated.
Methods: An online survey conducted by the Associatin des Patients Immunodéficients du Québec (APIQ) (10/2020–03/2021) of patients in Canada contained questions on SCIg use: reasons for choosing packaging and administration methods, training experiences, self‑infusion characteristics, and switching packaging methods. The survey captured structured patient‑reported outcomes such as treatment satisfaction (via TSQM), symptom state (via PASS), general health perception (via GHP), and physical and mental function (via PROMIS). Respondents using SCIg were compared by their SCIg packaging, and then stratified by their administration method in a sub-analysis.
Results: Sixty-six respondents were currently using vials, with 38 using a pump and 28 using manual push; 120 respondents were currently using PFS (5 and 10 mL sizes), with 38 using a pump and 82 using manual push. PFS users were associated with a significantly lower SCIg dose (p=0.02), a significantly shorter infusion preparation time (p=0.02), and a trend for shorter actual infusion time (p=0.07) compared with vial users. Treatment satisfaction was similar between vial and PFS users in terms of effectiveness and convenience, both overall and in the manual push subgroup; in the pump subgroup, vial users showed a trend for improved convenience compared with PFS users (p=0.07). Vial users were associated with greater global satisfaction compared with PFS users, both overall and in the manual push subgroup (both p=0.02).
Conclusions: PFS users were associated with 17% lower SCIg dose compared with vial users, consistent with wastage caused by drawing the product into syringes from vials. PFS users were also associated with shorter pre-infusion times, reflecting simpler administration mechanics compared with vial users. Higher global satisfaction among vial users compared with PFS users may be due to incompatibility of currently available PFS and pump sizes, and sub-optimal SCIg training delivered during the COVID-19 pandemic; patient experience on PFS is expected to improve once these temporary factors resolve.
Correlation and clinical significance of calcium channel blocker therapy for in-stent restenosis after percutaneous coronary intervention
Authors: Chen Haitao , Guo Jiqiang , Gu Linxia , Lin Yuanyuan , Zhu Kaiyi , Gao Yaolong , Gu Yu , Gao Yuping
Published: December 2022

Background
In-stent restenosis (ISR) is one of major complications after percutaneous coronary intervention (PCI) in patients with coronary artery disease(CAD). The prevention and treatment of ISR is not well established yet. This study explored the correlation and clinical significance of calcium channel blockers(CCB) and ISR .
Methods
Patients who received coronary angiography(CAG) after PCI in Department of Cardiology, The Third Clinical Medical College of Shanxi Medical University from November 2019 to April 2022 were collected, and the relationship between calcium channel blockers taken by patients before PCI and the occurrence time of in-stent restenosis as well as the severity of restenosis was analyzed. Chi-square test or t test, pearson correlation regression analysis and logistic regression analysis were conducted .
Results
The in-stent restenosis group (ISR group) and the non-stent restenosis group (no-ISR group) had significant differences in diabetes, previous myocardial infarction history, red blood cell distribution width, fasting blood glucose, ACC/AHA lesion classification, stent maximum diameter, total stent length, and stent expansion pressure (all P < 0.05). Patients with ISR had higher levels of total cholesterol, triglycerides, homocysteine(Hcy) and D- dimer in the preoperative oral calcium channel blocker group (CCBs group) than in the non-oral calcium channel blocker group (no-CCBs group). Moreover, the maximum balloon dilatation pressure and the degree of ISR in the CCBs group were lower, and the time interval for ISR was longer (all P < 0.05). Among the ISR patients with Hcy ≥ 10µmol/L, the no-CCBs group had lower levels of peripheral blood total cholesterol, triglycerides, Hcy and D-dimer, larger maximum balloon dilatation pressure and ISR, and a shorter time interval for ISR (P < 0.05).
Conclusion
The use of CCB has a direct correlation with the incidence, interval and severity of ISR. The use of CCB may delay the occurrence time of in-stent restenosis after PCI in patients, providing new ideas for the prevention and treatment strategies of ISR.
Tensor splitting preconditioners for multilinear systems
Authors: Karimi Saeed , Dehdezi Eisa Khosravi
Published: December 2022

In this paper, we propose some new preconditioners for solving multilinear system Ax^ {m−1} = b. These preconditioners are based on tensor splitting. We also present some theorems for analyzing and converging the preconditioned Jacobi, Gauss-Seidel, and SOR-type iterative methods. Numerical examples are presented to verify the efficiency of the proposed preconditioned methods.
Mathematics Subject Classification (2010). 15A10, 15A69, 15A72, 15A99, 65F10.
Germans’ awareness of refugees’ information barriers regarding health care access: a cross-sectional study
Authors: Schubert Saskia , Kluge Ulrike , Klapprott Felix , Ringeisen Tobias
Published: December 2022

Background:In light of their experiences on the journey and upon their arrival in the receiving society, refugees may have differentiated needs regarding health care. However, negative attitudes of the receiving society and a lack of information pose as barriers for refugees when trying to access health care services. In that sense, it is largely unknown, which antecedents positively affect Germans’ perception of information barriers that refugees face. Based on an extended version of the Empathy-Attitude-Action model, this study examined selected predictors of problem awareness in the form of perceived information barriers that refugees face, emphasizing the role of positive intercultural contact experiences.Methods:A sample of Germans (N= 910) completed a cross-sectional online survey with validated self-report measures. From the perspective of Germans, assessments covered positive intercultural contact, attitudes on refugees’ rights, the recognition of refugees’ socio-emotional support needs as a form of cognitive empathy, and the perception of refugees’ information barriers when accessing health care. We conducted structural equation modeling to examine hypothesized latent associations and specified three different models with unidirectional paths between the study variables, each allowing another direct path from intercultural contact to the variables. We determined the best model using the chi-square-difference test and tested for indirect effects along the paths through bias-corrected bootstrapping.Results:Our results show consistency with the Empathy-Attitude-Action model. We found Germans’ cognitive empathy towards refugees to be associated with more positive attitudes and a greater awareness of refugees’ information barriers. We further found more positive intercultural contact to be associated with greater cognitive empathy towards refugees and with more positive attitudes. While these contact experiences showed a slightly direct negative effect on Germans’ perception of refugees’ information barriers to accessing health care, the indirect effects via cognitive empathy and positive attitudes were positive.Conclusion:Previous positive intercultural contact may be directly and indirectly linked to greater awareness for refugees, helping Germans as the receiving community (1) to become more empathetic towards refugees, (2) to improve their attitudes towards refugees’ rights and to (3) raise consciousness for information barriers that refugees face when trying to access health care services.
Regulation of the TLR4 pathway by the SENP3 gene in a model of hypoxia-induced inflammation
Authors: 赵 思远 , Gu Yanlan , Zhang Youli , Wu Qian , Chen Daqing
Published: December 2022

Microglia are innate immune cells of the central nervous system. After the onset of Ischemic stroke, excessive neuroinflammation would cause further damage to brain tissue, which is characterized by microglial activation and the release of inflammatory cytokines. Earlier studies have shown that SENP3 is raised in the brain tissue of ischemic stroke animals. We further demonstrated that SENP3 induced TLR activation and the downstream production of proinflammatory mediators, such as TNF-a, IL-1β, and iNOS. Our study of the mechanism suggested that knocking down SENP3 in microglia significantly would decreased the deSUMOylating of MKK7 and the phosphorylation of JNK in TLR4 signaling pathway, inhibited TLR4 activation and the downstream production of proinflammatory mediators. This pathway could represent a potential therapeutic target for cerebral hypoxic diseases associated with microglial activation and the inflammatory response.
A 12-month follow-up of a selective, transdiagnostic prevention intervention for adolescents at-risk for emotional disorders: results from the PROCARE+ study
Authors: Vivas-Fernandez Manuel , Garcia-Lopez Luis-Joaquin , Piqueras Jose A , Espinosa-Fernandez Lourdes , Muela-Martinez Jose Antonio , Jimenez-Vazquez David , Diaz-Castela Mª del Mar , Ehrenreich-May Jill
Published: December 2022

Few studies have reported long-term follow-up data on selective preventive interventions for adolescents. No follow-up selective transdiagnostic preventive studies for adolescents at-risk for emotional disorders have been reported. To fill this gap, this study aims to provide the first follow-up assessment of a randomized controlled trial (RCT) studying selective transdiagnostic prevention in at-risk adolescents. A 12-month follow-up assessment was conducted with subjects who originally received either PROCARE (Preventive transdiagnostic intervention for Adolescents at Risk for Emotional disorders), PROCARE+, which includes the PROCARE protocol along with personalized add-on modules or an active control condition (ACC) based on emotional psychoeducation, and their respective booster session for each experimental condition. 82 subjects who completed these treatment conditions were available for the 12-month follow-up. Results demonstrate that the maintenance of gains for treated subjects in PROCARE and PROCARE+ one year after treatments are greater than in ACC, being PROCARE+ the one with the largest treatment outcome gains.
Knowledge, attitudes and practices of Adverse Drug Reaction reporting among healthcare professionals in Teaching Hospital Karapitiya
Authors: MT Madhushika , Jayasinghe SS , Liyanage PLGC , WAD Malinda , Abeykoon P
Published: December 2022

Objectives
The objectives of this study were to describe the knowledge, attitudes and practices of Adverse Drug Reactions (ADR) reporting among healthcare professionals in Teaching Hospital Karapitiya (THK).
Methodology
A descriptive cross-sectional study was conducted at THK. The healthcare professionals working in THK who were available during the study period were invited to the study. A self-administered pre-tested questionnaire was given to the participants. Respondents were evaluated for their knowledge, attitudes and practices related to ADR reporting. The data was analyzed using SPSS statistical software.
Results
Of the total 444 respondents, 31% were doctors and 69% were nurses. Majority of respondents, 90% (n=400) were aware about the term ADR, while 64.8% (n=288) could correctly define it. Among the respondents, 30.8% (n=137) knew about the types of ADR and only 15.5% (n= 70) were able to correctly mention a drug that is banned due to ADR. Among the respondents, only 38.7% (n=172) were aware about formal process of reporting ADR and, only 35.3% (n=157) stated that they have seen ADR reporting form. Further, only 33.7% (n=150) respondents have recognized ADR in the practice and only a small proportion 18.2% (n=81) have ever reported an ADR during their practice. Regarding attitudes of ADR reporting, overall 84.1 (n=373) had positive attitude towards ADR reporting while 13.54% (n=60) of them stayed neutral and 2.25% (n=10) had negative attitude towards ADR reporting.
Conclusions
Although the majority was aware about ADR and the importance of their reporting, the knowledge and practices regarding the spontaneous reporting of ADR is inadequate. However, most of the respondents have shown a positive attitude towards ADR reporting. Sincere and sustained efforts should be made by concerned bodies to improve the knowledge, attitudes, and practices of health care professionals.
Giant modulation of magnetoresistance in a van der Waals magnet by current-induce phase transition
Authors: Kim Sanghoon , Kim Kwangsu , Ahn Hyo-bin , Jin Munsu , Jeong Seyeob , Lee Donghyeon , Kwon Dohee , Kim Seong Been , Kim Sung Jong , Park Jungmin , Lee Nyun Jong , Koo Hyun Cheol , An Kyongmo , Moon Kyoung-Woong , Lee Changgu , Kim Se Kwon , Park Tae-Eon , Kim Bongjae , Kim Kyoo , Kim Kab-Jin
Published: December 2022

Efficient magnetization control is a central issue in magnetism and spintronics1-8. Particularly, there are increasing demands for versatile manipulation of magnetic states in van der Waals (vdW) magnets for spintronic devices with their unconventional functionalities9-13. The electric control of the vdW magnets has been achieved for the magnetization switching via spin torque, but current-induced phase transition between ferromagnetic-to-antiferromagnetic states without external magnetic field is yet to be demonstrated12,14,15. Here, we report the current-induced magnetic phase transition in a vdW ferromagnet Fe5GeTe2, resulting in a giant magnetoresistance. Based on magneto-transport measurements and relevant theoretical analysis, we demonstrate that the transition sequentially occurs through the layers by voltage difference across the vdW gap, induced by an in-plane current. The current-tunability of magnetic phase in Fe5GeTe2 opens a path for electric control of the magnetic properties, expanding our ability to use vdW magnets for diverse spintronic device applications.
USPIO combined with MR to long-term show the stem cells to repair the defect of articular cartilage
Authors: Jing Qing , Zhao Jingjing , Li Tongtong , Shi Wenjing , Xu Yang , Wang Wenhui , Zhu Jiahong , Liu Zhenyu , Qi Meiling , Zhen Junping
Published: December 2022

Backgroud:
Magnetic Resonance Imaging (MRI) is used to monitor the process of repairing articular cartilage defect by transplanting the bone marrow mesenchymal stem cell marked by Ultrafine Superparamagnetic Iron Oxide (USPIO) in the rabbit.
Methods
The Bone Marrow Stromal Cells (BMSCs) cells are isolated from rabbits injected with USPIO (20 mg/kg). Staining and cck-8 are used to detect the ability to form bone, fat cartilage. In the 4 rabbit groups of the double knee joint cartilage defect, the 3 groups are respectively injected the BMSCs-sodium alginate gel compound marked USPIO, BMSCs-sodium alginate gel compound, pure sodium alginate gel, while the blank group doesn't do anything. The rabbits are assessed by MRI and histological studying.
Results
Compared with the control group, the BMSCs marked by USPIO are the same in cell morphology. The proliferative and differentiation ability of BMSCs in rabbits is not affected by USPIO with a concentration of 20mg/kg. We find that the cartilage defects are gradually repaired in the two cell transplantation groups, and it is slowly repaired by BMSCs transplanting for the treatment of rabbit knee cartilage defects in the other groups. The labeled BMSCs could be used to treat the rabbit knee cartilage defect but could be indicated by MRI.
Conclusion
The experimental results show that the BMSCs marked by USPIO are the same in cell morphology compared with the control group.
Molecular docking studies on the inhibitory selectivity of cytochrome P450 2C9 by natural anti-arthritic compounds
Authors: Tan Boon Hooi , Ahemad Nafees , Pan Yan , Palanisamy Uma Devi , Othman Iekhsan , Yiap Beow Chin , Ong Chin Eng
Published: December 2022

Five natural anti-arthritic compounds, diacerein, rhein, glucosamines (glucosamine 3-sulfate, G3S, and glucosamine 6-sulfate, G6S), and chondroitin disaccharide Δdi-4S (C4S) were docked individually to the defined binding site in CYP2C9 based on published crystal structure (PDB code: 1R9O) in this study. All investigated ligands bound deep in the active site pocket in close proximity to the heme. Except for chondroitin, all ligands bonded to residues found in critical secondary structures that formed the boundary of active site cavity including B-C loop, F helix, F-G loop and I helix. A total of 12 amino acids were involved in the binding and all were critical residues located in four out of six substrate recognition sites (SRSs) that have been identified as important substrate binding and catalysis regions in other CYP isoforms. The relatively more potent binding (lower CDOCKER interaction energy) observed for diacerein and rhein compared to glucosamines and C4S are likely due to two main factors: higher number of bonds between ligand molecule and CYP2C9 active site residues (14 versus 0–4), and direct hydrophobic interaction with the heme moiety. The binding residues identified in both diacerein and rhein were the residues that also bonded with sulfaphenazole, the specific and potent CYP2C9 inhibitor. Collectively, the in silico data from this study have provided insights into structural features of CYP2C9 critical for inhibition, and formed basis for further exploration of structural determinants for potency and specificity of some commonly used natural anti-arthritic compounds in CYP2C9 inhibition.
A novel robust memetic algorithm for dynamic community structures detection in complex networks
Authors: Ranjkesh Somayeh , Masoumi Behrooz , Hashemi Seyyed Mohsen
Published: December 2022

Networks in the real world are dynamic and evolving. The most critical process in networks is to determine the structure of the community, based on which we can detect hidden communities in a complex network. The design of strong network structures is of great importance, meaning that a system must maintain its function in the face of attacks and failures and have a strong community structure. In this paper, we proposed the robust memetic algorithm and used the idea to optimize the detection of dynamic communities in complex networks called RDMA_NET (Robust Dynamic Memetic Algorithm). In this method, we work on dynamic data that affects the two main parts of the initial population value and the calculation of the evaluation function of each population, and there is no need to determine the number of communities in advance. We used two sets of real-world networks and the LFR dataset. The results show that our proposed method, RDMA_Net, can find a better solution than modern approaches and provide near-optimal performance in search of network topologies with a strong community structure.