bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuropsicologia de los trastornos de ansiedad
Authors: González Rocio , Parra-Bolaños Nicolás
Published: February 2023

Si bien existe cierta diversidad terminológica y conceptual respecto a la ansiedad, desde una conceptualización multidimensional se la considera como un estado emocional complejo, difuso y aversivo que se caracteriza por una aprensión excesiva irracional, intranquilidad, tensión, hipervigilancia y preocupación, acompañada de la activación del sistema nervioso autónomo en ausencia de un estímulo específico que la desencadene. Sin embargo, esta respuesta emocional que inicialmente es adaptativa se puede convertir en patológica y es aquí donde aparecen los trastornos de ansiedad que se caracterizan por presentar una dificultad para percibir los aspectos seguros de las situaciones de peligro y por una tendencia a subestimar las capacidades de afrontamiento. El objetivo de este trabajo es realizar una revisión del concepto de ansiedad y los trastornos asociados a ella desde una perspectiva neuropsicológica, explorándola desde las diferentes escuelas psicológicas hasta su estudio también desde una mirada neurobiológica. De esta manera, se realiza una distinción entre la ansiedad y el miedo y se enfatiza en la diferenciación entre ansiedad normal y ansiedad patológica. Por último, se analiza el impacto que tiene la ansiedad en el funcionamiento cognitivo y se destaca la importancia de su tratamiento.
PERANCANGAN BUSINESS CONTINUITY PLAN BERBASIS RISIKO PADA RSUD ARIFIN ACHMAD PEKANBARU
Authors: Syahril Syahril , Iqbal Dwi Muhammad , Diansyah Risnal
Published: February 2023

This study aims to provide guidance on the preparation of a Business Continuity Plan (BCP) document framework, which is tailored specifically to the needs and conditions of the company regarding business sustainability. The preparation of the framework is the result of the formulation between the needs and conditions of the company and the best practice framework of ISO 22301: 2012, as well as other related research. This will provide the results of a framework that is appropriate and specific to the conditions and needs of the company.The case study in this study was Arifin Achmad Hospital (Regional General Hospital), Pekanbaru. To improve customer service, this company uses information technology as a supporting resource for its daily operations. So that BCP will be a solution to help companies overcome disruptions and threats that can disrupt the performance of the company's information technology.This research was conducted with ISO 27001:2012 risk analysis method and FMEA method with ISO 31000: 2009 risk management stages combined with an analysis of the risk impacts of ISO 22317: 2015 and the ISO 22301: 2012 BCMS Framework. The results of the framework willbe verified and validated through confirmation and validation on the company. This research shows that BCP in each company is unique and different
PENERAPAN LOGIKA FUZZY DENGAN METODE SUGENO UNTUK MENENTUKAN BESARAN KOMISI PADA LAYANAN JASTIP PLGD.STORE
Authors: Asrianto Rudy , Effendi Aprianda
Published: February 2023

Shopping entrusted goods service or most commonly known as jastip (jasa titip) allowing consumen to buy goods through providers of services that are usually different cities or countries. People usualy use this service to purchase goods that are not available in their city, or they have limited acces to the goods. This study aims to determine the amount of commission feee on the PLGD.STORE jastip service by considering the factors that affect the commission on the jastip service. The aplication of Fuzzy Logic in this service is to regulate the ammount of commission fee. The basis fordetermining commission fee is based on the price, the distance and the volume of the product. In this research, we use Sugeno Logic to determine the ammount of the commision fee. The final results of this study are objective with theoretical calculations and are expected to be able to solve the problems in PLGD.STORE and give a win-win solution for both of the jastip service providers and the PLGD.STORE jastip consumers.
ANALISIS TINGKAT KEPUASAN PENGGUNA APLIKASI SIGNAL NASIONAL MENGGUNAKAN METODE END USER COMPUTING SATISFACTION (EUCS) (Studi Kasus : Badan Pendapatan Daerah Provinsi Riau (BAPENDA)
Authors: Arribe Edo , Aryanto Aryanto , Aulia Sandra
Published: February 2023

The National Signal application is a national digital Samsat application that can make it easier for the Indonesian people to make tax payments. The National Signal application, which will be held in Pekanbaru on August 25, 2021. Problems with the National Signal Samsat also often occur to some users of the National Signal application. The application requires a measurement of thelevel of end user satisfaction, so that it can find out the condition of application user satisfaction. This study has the aim of knowing user satisfaction using the EUCS method, this method is used because it is in accordance with the problems that existin the National Signal application users to make benchmarks on the dimensions that exist in the EUCS method. amount of 16%. While the other 4 variables have a high percentage of satisfaction with an average of 72-82%. And the results of the T test where the hypothesis on the accuracy variable section is rejected because there is no effect on users of the National Signal Application. Based on the overall results of the research, it can be seen that users of the National Signal application are satisfied withthe performance of the application with the highest score from the results of filling out the questionnaire from 222 samples which state that the National Signal Application is a complete information provider for paying the SAMSAT tax.
ગુજરાતમાં સમગ્ર શિક્ષા દ્વારા શરૂ કરવામાં આવેલ હોમ લર્નિંગ
કાર્યક્રમના સાધનોની અસરકારકતાનો અભ્યાસ
Authors: રામજીભાઈ રોહિત રતિલાલ , મલેક પી.એમ.
Published: February 2023

COVID – 19 ની મહામારીએ સમગ્ર દેશને લોકડાઉન કરવામાં મજબૂર કર્યું. ત્યારે તમામ 1 થી 12 ધોરણના બાળકોનું શિક્ષણ પણ લોકડાઉન થઈ ગયું. જેને કારણે વાલીઓ , બાળકો અને શાળાઓ બાળકોના અભ્યાસ અંગે ચિંતા કરવા લાગ્યા. આ ચિંતાનો અંત લાવવા માટે ગુજરાત સરકારના શિક્ષણ વિભાગ દ્વારા સમગ્ર શિક્ષા દ્વારા બાળકોનો અભ્યાસ અધૂરો ન રહે અને બાળકોનું વર્ષ બરબાદ ના થાય તે માટે બાળકોને હોમ લર્નિંગ કરાવવાનું નક્કી કર્યું. જેમાં સરકારે સમગ્ર શિક્ષાની મદદથી બાળકોને હોમ લર્નિંગ સાહિત્ય ઘરે ઘરે પોંહચાડ્યું તથા બાળકોને આધુનિક સોસિયલ મિડીયાનો ઉપયોગ કરીને પણ હોમ લર્નિગ કરાવવામાં આવવા લાગ્યું. બાળકોને હોમ લર્નિંગના ક્યાં કયાં માધ્યમોથી આપી શકાય તે માટે “હોમ લર્નિગઇક્વિપમેંટ” સર્વે પણ કરવામાં આવ્યો. બાળકોને જરૂરી સાહિત્યનું છાપકામ કરીને ઘરે ઘરે પોંહચે તેની કાળજી લેવામાં આવી. આમ , બાળકોને ઘરે બેઠા શિક્ષણ મળી રહે તેની પુરતી વ્યવસ્થા ગુજરાત સરકાર દ્વારા સમગ્ર શિક્ષાના મધ્યમથી કરવામાં આવી. હોમ લર્નિગમાં યોગ્ય રીતે શાળાના શિક્ષકો દ્વારા બાળકોને માર્ગર્શનઅને સૂચનો આપવામાં આવે છે કે નહીં તથા હોમ લર્નિંગ થાય છે કે નહીં તે ચકાસવા માટે બી.આર.સી.કો-ઓર્ડીનેટર , સી.આર.સી.કો-ઓર્ડીનેટર દ્વારા શાળાના શિક્ષકો અને બાળકોના ક્રોસ ચકાસણીની વ્યવસ્થા પણ કરવામાં આવી.
RUSSIA VS. UKRAINE: ADVANTAGES, DISADVANTAGES AND LESSON FOR INDIA
Authors: Kamboj Rajni
Published: February 2023

Russia and Ukraine war started on 24th Feb., 2022. After 2nd World war, it is the largest military conflict in Europe. The war negatively affected the entire global market. The paper tries to find out why Russia and Ukraine becomes enemy? The paper discuss about various reasons of dispute between Russia and Ukraine. The paper determines the various sanctions imposed by different countries on Russia and the steps taken by Russia to save its economy. The study discuss about positive and negative impact of war on Indian economy and what actually India can learn from Russia and Ukraine war. The data has been collected from secondary resources. The study concluded that it is necessary for a country to be self-reliant in defense matters. Each country needs to advance itself in technology. Like Ukraine, The defense services allegiance must not to the political party but to the constitution
Implementasi Hak atas Lingkungan Hidup yang Bersih, Sehat, dan Berkelanjutan dalam Konteks Hukum Indonesia
Authors: Binawan Andang , Soetopo Maria Grasia Sari
Published: February 2023

Terbitnya Resolusi Majelis Umum Perserikatan Bangsa-Bangsa (PBB) Nomor A/RES/76/300 mengakui hak atas lingkungan hidup yang bersih, sehat, dan berkelanjutan sebagai hak asasi manusia (HAM). Berkaitan dengan hal itu, artikel ini bertujuan  menganalisis dampak terbitnya Resolusi PBB tersebut terhadap hukum Indonesia. Artikel ini menggunakan metode penelitian hukum normatif yang dilakukan dengan menggunakan pendekatan perundang-undangan dan pendekatan konseptual. Hasil penelitian ini pada pokoknya menunjukkan bahwa berbagai upaya masih perlu dilakukan untuk mendukung pengakuan terhadap hak atas lingkungan hidup yang bersih, sehat, dan berkelanjutan. Dalam perspektif hukum internasional, Resolusi PBB No. A/RES/76/300 perlu ditindaklanjuti dengan konvensi baru untuk menegaskan hak atas lingkungan hidup yang bersih, sehat, dan berkelanjutan sebagai HAM. Indonesia sebagai negara yang terlibat dalam resolusi tersebut memiliki kewajiban moril untuk mendukung pemenuhan hak atas lingkungan hidup yang bersih, sehat, dan berkelanjutan. Penyempurnaan terhadap asas keadilan sebaiknya dilakukan terhadap beberapa undang-undang. Selain itu, Pemerintah juga perlu meningkatkan peran pengawasan dengan meningkatkan intensitas penegakan hukum untuk menjamin kepatuhan masyarakat.
South Africa Social Listening Reports for COVID-19 vaccine hesitancy
Authors: Combrink Herkulaas
Published: February 2023

Collection of data reports and weekly reports that assisted the COVID-19 outbreak in terms of data, meta data and trends that aided in the fight against public healthcare interventions such as public vaccine programmes.
Intensity Interferometry Observations of the Hα Envelope of γCas with MéO and a Portable Telescope
Authors: Matthews Nolan , Rivet Jean-Pierre , Vernet David , Hugbart Mathilde , Labeyrie Guillaume , Kaiser Robin , Chabé Julien , Courde Clément , Lai Olivier , Vakili Farrokh , Garde Olivier , Guerin William
Published: February 2023

We report on observations of the extended environment of the bright Be star γ-Cas performed using intensity interferometry measurements within its Hα emission line. These observations were performed using a modified version of the I2C intensity interferometry instrument installed onto the 1.54 m MéO optical metrology telescope and a portable 1 m telescope (T1M). In order to better constrain the extent of the H α envelope, observations were performed for two different positions of the T1M telescope, corresponding to an intermediate and long baselines in which the extended region was partially and fully resolved. We find that the observed data are consistent with past interferometric observations of γ-Cas. These observations demonstrate the capability to equip optical telescopes of different optical designs with intensity interferometry capabilities and illustrate the potential to scale a similar system onto many additional telescopes.
Discovery of 20 UV-emitting SNRs in M31 with UVIT
Authors: Leahy Denis , Monaghan Christopher , Ranasinghe Sujith
Published: February 2023

We present the first catalog of supernova remnants (SNRs) in M31 that exhibit diffuse ultraviolet (UV) emission. UV images of M31 were obtained by the Ultraviolet Imaging Telescope (UVIT) on the AstroSat satellite, and the list of SNRs was obtained from X-ray, optical, and radio catalogs of SNRs in M31. We used the UVIT images to find SNRs with diffuse emission, omitting those too contaminated with stellar emission. A total of 20 SNRs in M31 were detected with diffuse UV emission. Fluxes in the UVIT F148W, F169M, F172M, N219M, and N279N filters are measured for these SNRs. The luminosities are compared to those computed from the spectra of seven known UV-emitting SNRs in the Milky Way, the Large Magellanic Cloud, and the Small Magellanic Cloud. We find similar spectral shapes between the known and the M31 UV-emitting SNRs. The spectral shapes and the diffuse nature of the emission are good evidence that the UV emissions are dominated by line emissions, like known SNRs, and the UV is associated with the SNRs. Models are applied to the six SNRs with X-ray spectra. The main difference is that the two X-ray/UV SNRs are Type Ia and the four X-ray/non-UV SNRs are core-collapse or unknown type. A comparison of M31 SNRs in different wave bands shows that most are detected optically, similar to the case for other nearby galaxies. A total of 19 of the 20 UV-emitting SNRs are detected optically, expected because both UV and optical are from forbidden and recombination lines from shock-ionized gas.
WIYN Open Cluster Study. LXXXVII. Hubble Space Telescope Ultraviolet Detection of Hot White Dwarf Companions to Blue Lurkers in M67
Authors: Nine Andrew C. , Mathieu Robert D. , Gosnell Natalie M. , Leiner Emily M.
Published: February 2023

We present the results of our Hubble Space Telescope far-ultraviolet survey of the blue lurkers (BLs) in M67. We find evidence for two white dwarf (WD) companions among the BLs that are indicative of mass transfer from an evolved companion, one in WOCS 14020 and the other in WOCS 3001. The cooling ages of the WDs suggest that mass transfer in these systems occurred ∼300–540 Myr and ∼600–900 Myr ago, respectively. The rotation periods and cooling ages of the BLs are consistent with spin-up and subsequent single-star spin-down models, and binary evolution models yield plausible evolutionary pathways to both BLs via highly nonconservative mass transfer. We conclude that the BLs are lower-luminosity analogs to the classical blue stragglers.
A Model for Gradual-phase Heating Driven by MHD Turbulence in Solar Flares
Authors: Ashfield William , Longcope Dana
Published: February 2023

Coronal flare emission is commonly observed to decay on timescales longer than those predicted by impulsively driven, one-dimensional flare loop models. This discrepancy is most apparent during the gradual phase, where emission from these models decays over minutes, in contrast to the hour or more often observed. Magnetic reconnection is invoked as the energy source of a flare, but should deposit energy into a given loop within a matter of seconds. Models which supplement this impulsive energization with a long, persistent ad hoc heating have successfully reproduced long-duration emission, but without providing a clear physical justification. Here we propose a model for extended flare heating by the slow dissipation of turbulent Alfvén waves initiated during the retraction of newly reconnected flux tubes through a current sheet. Using one-dimensional simulations, we track the production and evolution of MHD wave turbulence trapped by reflection from high-density gradients in the transition region. Turbulent energy dissipates through nonlinear interaction between counter-propagating waves, modeled here using a phenomenological one-point closure model. Atmospheric Imaging Assembly EUV light curves synthesized from the simulation were able to reproduce emission decay on the order of tens of minutes. We find this simple model offers a possible mechanism for generating the extended heating demanded by observed coronal flare emissions self-consistently from reconnection-powered flare energy release.
The Impact of Spin-kick Alignment on the Inferred Velocity Distribution of Isolated Pulsars
Authors: Mandel Ilya , Igoshev Andrei P.
Published: February 2023

The speeds of young isolated pulsars are generally inferred from their observed 2D velocities on the plane of the sky under the assumption that the unobserved radial velocity is not special, i.e., that the measured 2D velocity is an isotropic projection of the full 3D velocity. However, if pulsar spins are preferentially aligned with kicks, then the observer’s viewing angle relative to the pulsar velocity vector is in fact special because the direction of the spin impacts the detectability of the pulsar. This means that the measured 2D velocity of observable pulsars is not an isotropic projection, which affects inference on 3D velocities. We estimate this effect and conclude that it could lead to a ∼15% systematic overestimate of neutron-star natal kicks if young pulsars have high obliquity angles and narrow beams, but the exact correction factor depends on the distribution of beam-spin and spin-kick misalignment angles and beam widths.
Probing the Jet–Torus Interaction in the Radio Galaxy NGC 1052 by Sulfur-bearing Molecules
Authors: Kameno Seiji , Sawada-Satoh Satoko , Impellizzeri C. M. Violette , Kohno Kotaro , Martín Sergio , Espada Daniel , Nakai Naomasa , Sugai Hajime , Terashima Yuichi , Lee Minju M. , Kawakatu Nozomu
Published: February 2023

The radio galaxy NGC 1052 casts absorption features of sulfur-bearing molecules, H2S, SO, SO2, and CS toward the radio continuum emission from the core and jets. Using the Atacama Large Millimeter/submillimeter Array, we have measured the equivalent widths of SO absorption features in multiple transitions and determined the temperatures of 344 ± 43 K and 26 ± 4 K in submillimeter and millimeter wavelengths, respectively. Since submillimeter and millimeter continuum represents the core and jets, the high and low temperatures of the absorbers imply a warm environment in the molecular torus and cooler downstream flows. The high temperature in the torus is consistent with the presence of 22 GHz H2O maser emission, vibrationally excited HCN and HCO+ absorption lines, and sulfur-bearing molecules in the gas phase released from dust. The origin of the sulfur-bearing gas is ascribed to the evaporation of the icy dust component through a jet–torus interaction. Shock heating is the sole plausible mechanism to maintain such a high temperature of gas and dust in the torus. The implication of the jet–torus interaction also supports the collimation of the sub-relativistic jets by the gas pressure of the torus.
Simultaneous Time-monitoring Observations of H2O and SiO Masers toward the Supergiant VX Sagittarii
Authors: Yoon Dong-Hwan , Cho Se-Hyung , Yang Haneul , Yun Youngjoo , Kim Jaeheon
Published: February 2023

We performed simultaneous monitoring observations of the 22.2 GHz H2O and 43.1/42.8/86.2/129.3 GHz SiO masers toward the red supergiant VX Sagittarii using the Korean VLBI Network single-dish telescopes. The observations were conducted about every 2 months from 2013 May to 2019 January (30 epochs in total). They included four optical maxima in the active phase of the optical pulsation cycles. The line profile of a H2O maser always comprised various velocity components with a wider velocity range and varied from highly redshifted to blueshifted velocities with respect to the stellar velocity, in contrast to those of the SiO masers. We examined the relation between peak intensities and velocities of 11 detailed components in the line profile of the H2O maser and the pulsation phases. The peak intensity of each component generally exhibited a better correlation with the pulsation phases than that of total intensity. The peak velocities of several components gradually decreased or increased with respect to the stellar velocity, implying an accelerating motion and the development of asymmetries in the H2O maser region. The characteristics of four transition SiO maser properties were compared according to the stellar pulsation phases. The intensity and velocity variation trend of the 43.1 GHz SiO maser was similar to that of the 42.8 GHz SiO maser. However, the variation trend of the 43.1 and 42.8 GHz SiO masers was different from that of the 86.2 and 129.3 GHz SiO masers. This difference stems from the different location of each maser reflecting a different excitation condition.
A Comparative Study of Solar Active Region 12371 with Data-constrained and Data-driven Magnetohydrodynamic Simulations
Authors: Inoue Satoshi , Hayashi Keiji , Miyoshi Takahiro , Jing Ju , Wang Haimin
Published: February 2023

We performed two data-based magnetohydrodynamic (MHD) simulations for solar active region 12371, which produced an M6.5 flare. The first simulation is a full data-driven simulation where the initial condition is given by a nonlinear force-free field (NLFFF). This NLFFF was extrapolated from photospheric magnetograms approximately 1 hr prior to the flare, and then a time-varying photospheric magnetic field is imposed at the bottom surface. The second simulation is also a data-driven simulation, but it stops driving at the bottom before the time of flare onset and then switches to the data-constrained simulation, where the horizontal component of the magnetic field varies according to an induction equation, while the normal component is fixed with time. Both simulations lead to an eruption, with both simulations producing highly twisted field lines before the eruption, which were not found in the NLFFF alone. After the eruption, the first simulation based on the time-varying photospheric magnetic field continues to produce sheared field lines after the flare without reproducing phenomena such as postflare loops. The second simulation reproduces the phenomena associated with flares well. However, in this case, the evolution of the bottom magnetic field is inconsistent with the evolution of the observed magnetic field. In this Letter, we report potential advantages and disadvantages in data-constrained and data-driven MHD simulations that need to be taken into consideration in future studies.
Fractal Aggregates of Submicron-sized Grains in the Young Planet-forming Disk around IM Lup
Authors: Tazaki Ryo , Ginski Christian , Dominik Carsten
Published: February 2023

Despite rapidly growing disk observations, it remains a mystery what primordial dust aggregates look like and what the physical and chemical properties of their constituent grains (monomers) are in young planet-forming disks. Confrontation of models with observations to answer this mystery has been a notorious task because we have to abandon a commonly used assumption, perfectly spherical grains, and take into account particles with complex morphology. In this Letter, we present the first thorough comparison between near-infrared scattered light of the young planet-forming disk around IM Lup and the light-scattering properties of complex-shaped dust particles. The availability of scattering observations at multiple wavelengths and over a significant range of scattering angles allows for the first determination of the monomer size, fractal dimension, and size of dust aggregates in a planet-forming disk. We show that the observations are best explained by fractal aggregates with a fractal dimension of 1.5 and a characteristic radius larger than ∼2 μm. We also determined the radius of the monomer to be ∼200 nm, and monomers much smaller than this size can be ruled out on the premise that the fractal dimension is less than 2. Furthermore, dust composition comprising amorphous carbon is found to be favorable to simultaneously account for the faint scattered light and the flared disk morphology. Our results support that planet formation begins with fractal coagulation of submicron-sized grains. All the optical properties of complex dust particles computed in this study are publicly available.
Mitochondrial genome of Acheilognathus barbatulus (Cypriniformes, Cyprinidae, Acheilognathinae): characterisation and phylogenetic analysis
Authors: Yu Jinhui , Chen Xin , Liu Ruyao , Tang Yongtao , Nie Guoxing , Zhou Chuanjiang
Published: February 2023

Acheilognathus barbatulus is distributed in Yangtze River, Yellow River and Pearl River systems in China. Genome data can help to understand the phylogenetic relationships of A. barbatulus, but its complete mitochondrial genome has not been published. We determined the complete mitochondrial genome structure and characteristics of this species and constructed a comprehensive phylogenetic tree, based on mitochondrial genome data of several species of Acheilognathus, Rhodeus and Pseudorasbora parva. The complete length of the mitochondrial genome of A. barbatulus is 16726 bp. The genome is a covalently closed double-stranded circular molecule containing 13 protein-coding genes, two ribosomal RNAs, 22 transfer RNAs, a D-loop and a light strand replication initiation region. The base composition of the complete mitochondrial genome is A (29.33%) > T (27.6%) > C (26.12%) > G (16.95%), showing a strong AT preference and anti-G bias. All 13 PCGs have different degrees of codon preference, except for cytochrome c oxidase 1, which uses GTG as the start codon. All the PCGs use ATG as the start codon and the stop codon is dominated by TAG. The encoded amino acids Leu and Ser exist in two types, whereas the rest are all present as one type, except for tRNASer (GCT), which lacks the D-arm and has an incomplete secondary structure, all other tRNAs can be folded to form a typical cloverleaf secondary structure. Based on the 13 PCG tandems, the Maximum Likelihood and Bayesian trees were constructed, based on the concatenated sequence of 13 PCGs for the genera Acheilognathus and Rhodeus, with Pseudorasbora parva as the outgroup. Acheilognathus barbatulus, Acheilognathus tonkinensis and Acheilognathus cf. macropterus were clustered together and the most closely related. The results of this study enrich the mitochondrial genomic data of Acheilognathus and provide molecular and genetic base information for species conservation, molecular identification and species evolution of Acheilognathinae.
An in silico investigation of 1,2,4-triazole derivatives as potential antioxidant agents using molecular docking, MD simulations, MM-PBSA free energy calculations and ADME predictions
Authors: Karpun Yevhen , Fedotov Sergiy , Khilkovets Anastasiia , Karpenko Yuriy , Parchenko Volodymyr , Klochkova Yana , Bila Yuliia , Lukina Iryna , Nahorna Natalia , Nahornyi Volodymyr
Published: February 2023

In this study, we’ve performed computable studies of previously synthesized 1,2,4-triazole derivatives by virtual screening due to antioxidant activity. Six enzymes responsible for regulating oxidative stress were selected as key targets. One hundred and twelve compounds were subjected to semi-flexible molecular docking, which resulted in the selection of 23 substances based on binding energy for further ADME analysis. In addition, molecular dynamics studies of complexes with the best docking scores, reference complexes and apo-proteins were described in detail here. The results of 100 ns modeling (RMSD, RMSF, SASA, Rg, PCA) indicate great stability during the formation of complexes with our two potential compounds, as well as favorable binding energy, which was determined theoretically by means of the MM/PBSA method, thereby increase the likelihood of their acting as promising inhibitors of selected enzymes.
Combination of Empagliflozin and Liraglutide protects heart against isoproterenol-induced myocardial infarction in rats
Authors: Kurniati Neng Fisheri , Fathadina Almira
Published: February 2023

Cardiovascular benefit of new anti-hyperglycemic agent such as glucagon like peptide-1 receptor agonist (GLP-1RA) or sodium glucose co-transporter-2 inhibitor (SGLT2i) has been proven, with the proposed-mechanism that might be complementary. We investigated the effects of its combination on blood glucose profile and cardiac biomarkers. The rats were given lipid emulsion for 2 weeks, followed by a single dose of streptozotocin (STZ) 35 mg/kg BW, then treated with empagliflozin and/ liraglutide for 30 days while receiving isoproterenol (ISO) 85 mg/kg on day 29 and 30. The results showed no superior improvement on fasting blood glucose (FBG) and insulin sensitivity (KITT) in the combination group compared to empagliflozin/liraglutide group. However, the combination group showed a higher inhibition in almost all biomarkers, specifically against the elevation of CK-MB compared to one of these agents alone. The histopathological examination using H&E staining even showed a minimal inflammation and gap between cardiomyocytes. These findings may indicate the combination of empagliflozin and liraglutide has a better cardiac protection effect.
Les variables didactiques en badminton : une revue de littérature
Authors: Klonowski Paul , Musard Mathilde , Loizon Denis
Published: February 2023

Résumé : L’objectif de cette revue de littérature est de rechercher dans les écrits scientifiques et professionnels des 40 dernières années les traces d’un concept appartenant au champ scientifique de la didactique : les variables didactiques (VD). Cette revue poursuit un triple objectif : définir le concept de VD, identifier les différentes catégorisations de VD et les VD spécifiques utilisées dans le contexte de l’enseignement du badminton en EPS. En se basant sur une méthodologie de revue de littérature (Dumez, 2011), nous avons constitué un corpus scientifique de 52 articles et un corpus professionnel de 21 documents, pour un total de 73 documents. Après les avoir analysés, nous avons mis en évidence que les VD représentent un concept peu mobilisé par les chercheurs comme les professionnels. Les variables sont parfois oubliées, parfois incomprises, mais les travaux tendent progressivement à prendre en compte différentes facettes de ce concept didactique. Suite à cette revue de littérature, nous distinguons les VD de commande, les VD générales et spécifiques au badminton. Parmi les VD spécifiques au badminton, nous avons identifié les VD techniques, avec, le service, le coup technique choisi parmi le smash, le dégagé et l’amorti entre autres et les VD stratégiques, avec le jeu dans la longueur, sur les côtés, changer de rythme pour créer la rupture par exemple.
Does green innovation have an important role in the effect of board gender diversity and firm performance?
Authors: Mahsina Mahsina , Agustia Dian
Published: February 2023

Purpose: This research is motivated by the development of the debates on the role of board gender diversity and green innovation on firm performance. This study aims to investigate the mediating role of green innovation on the effect of board gender diversity and firm performance.Design/methodology/approach: This research employs regression analysis. The dataset using samples of 518 public listed companies on the Indonesia Stock Exchange over the period of 2017–2019.Findings: Based on 1,554 firm-year observations for the period of 2017 to 2019, the results revealed that the presence of board gender diversity had a negative effect on green innovation and the relationship between green innovation and firm performance was insignificant. However, we found that board gender diversity showed a positive effect on firm performance. More importantly, green innovation is not an essential factor in the relationship between board gender diversity and firm performance.Research limitations/implications: This research used only sample companies in a single country, therefore, the theory implication might apply to emerging countries with similar conditions (Indonesia). Future research needs to do more in more samples with multiple countries. Also, future research might apply with others corporate governance characteristics variables.Practical implications: Our result findings, first, can be used to support the company to implement the alternative of the low cost of green innovation. Second, this paper can be used to give insight for the government of Indonesia in supporting the business-based environment by strengthening the regulation on the environmental aspect, provide the incentives for companies with green innovation implementation.Social Implications: This paper’s result can be used as a reference to enhance women’s participation in the board’s firm. Furthermore, this study also brings the changes of the community behavior to use and consume the product with green and environmental concerns.Originality/value: Our study contributes to the literature in many ways, first, on gender literature that the presence of female directors on board is still proven to have more commitment to improve the firm performance. Second, the findings also provide an important insight of green innovation’s role in the relationship between board gender diversity and firm performance that it is still a controversial issue, where green innovation is not an important factor in the relationship of gender to firm performance improvement.
The distribution of exterior transmission eigenvalues for spherically stratified media
Authors: Zhang Yalin , Zhao Jia
Published: February 2023

The exterior transmission eigenvalues corresponding to spherical symmetry media and spherically symmetric eigenfunctions are considered. Under various coefficient conditions, we give the number and the asymptotic distribution (described by the subscript numbers) of these eigenvalues in the complex plane.
Staff Perceptions of Dying and Death in a Pediatric Cardiac Intensive Care Unit During COVID-19
Authors: Moynihan Katie M. , Bailey Valerie , Beke Dorothy M. , Alizadeh Faraz , Gauvreau Kimberlee , Snaman Jennifer M.
Published: February 2023

Background

Strict visitor restrictions during the COVID-19 pandemic have been associated with staff moral distress in numerous clinical settings, yet little is known about effects on perceptions of pediatric end-of-life care.

Objective

To determine the effect of COVID-19 visitor restrictions on perceptions of quality of dying and death.

Methods

This was a cross-sectional survey of interdisciplinary staff caring for dying children in a cardiac intensive care unit with flexible visitation allowances compared with published policies reported in the literature at the time.

Results

No significant difference in perceptions of quality of dying and death was found between the prepandemic and pandemic periods despite similar clinical care provision. The relatively less stringent allowances at end of life did not adversely affect staff risk for infection.

Conclusions

The findings support affording some flexibility to visitation at end of life, which may mitigate negative staff perceptions of quality of dying and death. With the profound effects of COVID-19 on end-of-life care provision, these results may have implications for future global challenges.
Herder and Crop Farmer Conflict: A Perspective in North-Central Nigeria
Authors: Bwala Madu Ali , Mgbemere Victoria , Adedeji Sharafadeen
Published: February 2023

Conflict in the Nigerian agricultural community has in recent times attracted attention at the national level, this is because crop farmers have fled their communities due to the violence. This study was conducted in the north-central region of Nigeria to investi-gate the conflict between crop farmers and herders in the area. The study used the random sample technique, where one hundred and twenty crop farmers were sampled and interviewed from selected communities. Descriptive statistics, Likert-type scale, and Chi-square were used for the analysis. Observations revealed that the farmers are aware of the existence and location of the stock route. Results revealed that the triggers of conflict between the two stakeholders in the agricultural community include rape, rus-tling, crop damage, pollution of the water point, access to grazing lands, and bush burning. The implications of the conflict include loss of property, loss of lives, and crop damage. Identified institutions involved in resolving conflict in the area are traditional insti-tutions, farmer associations, local government authorities, and the court of law. The study further revealed that the institutions’ effectiveness in resolving conflicts varies with the triggers. The analysis further reveals that the traditional institution is the most effective in managing the conflict but the least used avenue in the study area. Therefore, it was recommended that grazing reserve demarcation for herdsmen should be carried out along the various grazing tracks to avoid encroachment into farmland.
Do the Transaction Cost Determinants Affect the Livelihoods of SANASA Beneficiaries? A Case of Colombo District, Sri Lanka
Authors: Amarasiri M. M. P. L. , Priyanath H. M. S.
Published: February 2023

The livelihood development of low-income groups is a big challenge in many less developed countries. Meanwhile, scholars argue that Transaction Cost (TC) is the main factor that averts the livelihood improvement of low-income groups. This study attempted to examine how the Livelihood Success (LS) of the low-income groups is affected by the determinants of the TC. The study selected the members of SANASA society, one of the leading cooperative societies involving livelihood improvement activities in Sri Lanka. The study selected the Colombo district, the main commercial region in Sri Lanka to conduct the survey and gathered data from 130 SANASA beneficiaries, employing multistage sampling. A structural questionnaire was administered to collect primary data which were analyzed using the Partial Least Square Structural Equation Modeling. The results revealed that the TC determinants; uncertainty, and opportunism have a positive relationship with TC and negatively relate to LS. Meanwhile, rational ability and transaction frequency have negatively affected TC and positively impacted LS. The TC has a partial mediator role in the relationship between TC determinants and the LS of SANASA beneficiaries. Thus, the study provides a significant contribution to the literature by providing empirical evidence of the practical efficacy of TC and its impact on LS of the SANASA beneficiaries. Further, the study enables the policymakers and SANASA beneficiaries to develop strategies to mitigate TC by improving the rational ability and transaction frequency, both helping to avoid the opportunistic behavior of exchange partners and decreasing the transaction uncertainty, improving LS.
A Historical Study of the Matiyaganē Mayurāwathi Rajamahā Vihāraya
Authors: Gamage G. C. L. , Rathanasara K.
Published: February 2023

Matiyagane Mayurawathi Raja Maha Viharaya is a temple in the Narammala Divisional Secretariat Division in the Kurunegala District of the North Western Province. This temple has a history of about two thousand years. However, the long history of this temple has not been examined in depth yet. Accordingly, the historical significance of this temple will be studied through this investigation. Both primary sources and secondary sources were used for this study. In addition, in-depth interviews were conducted with selected people living in the area who know the field. The field observation method also was used for this research. This temple started in the Anuradhapura era and has remained a monastery until today. This research examines how the temple was qualitatively associated with history and national history from the Anuradhapura period to the Kotte period. Accordingly, this research aims at investigating the history of the Matiyagane Mayurawathi Raja MahaViharaya and the adjacent area from a historical point of view. It was clear that the Mayurawathi Rajamaha Viharaya in Matiyagane was associated with religious history and the political and social conditions in the area.
Study on the Mechanism and Molecular Docking Verification of Buyang Huanwu Decoction in Treating Diabetic Foot
Authors: Zhong Da-Yuan , Li Lan , Li Huan-Jie , Ma Ruo-Meng , Deng Yi-Hui
Published: February 2023

Objective:

The objective of this study was to investigate the molecular mechanism of Buyang Huanwu decoction (BYHWD) in the treatment of diabetic foot (DF).

Methods:

The TCMSP, BATMAN, PubChem, PharmMapper, UniProt, GeneCards, Webgestalt, and Kobas databases were used to obtain the structures, targets, main biological functions, and pathways of the active ingredients of BYHWD, and the results were visualized using Cytoscape3.6.1, Ledock, and PyMol software.

Results:

A total of 82 active components of BYHWD and 193 targets related to BYHWD were identified, and 5295 genes related to DF were identified using the GeneCards database, including 65 key targets of BYHWD in the treatment of DF. GO and KEGG enrichment analyses of the 65 targets for BYHWD treatment of DF showed that 47 GO items were involved in the treatment. It was mainly involved in biological processes, such as biological regulation, metabolism, and stress response. It is primarily involved in protein binding, ion binding, nucleotide binding, and other molecular functions. It is mainly involved in membrane encapsulation, membrane lumen closure, and other biological components and involved in the VEGF, TNF, RAS, RAP1, PI3K-AKT, MAPK, and IL-17 signaling pathways. Most targets were enriched in the PI3K-AKT and MAPK signaling pathways. Molecular docking results showed that the 59 key active components of BYHWD had strong binding activity with 64 key DF targets.

Conclusion:

The therapeutic effect of BYHWD on DF is based on the pharmacological effects of multiple targets and pathways.
Immature orbital teratoma: A rare case diagnosed in utero - A clinicopathological case report
Authors: Brandao Vitória , Neves Luiza M. , Rangel Leonardo G. , Fiúza Stéfano do A. , Sobreira Thaís , Régis-Pacheco L. Frederico , Neves Ricardo A. , Régis-Pacheco Luiz F.
Published: February 2023

To report a rare case of orbital teratoma diagnosed in utero by ultrasound examination at 24 + 4 weeks of gestation. The fetus was delivered by cesarean section, by terminative medical indication, at 39 weeks of pregnancy, due to the possibility of dystocia caused by the size of the tumoral mass, or the risk of tumor rupture during vaginal delivery, with risk to fetal survival. The neonate, a 3 day-old female patient was examined in our Department with a large tumoral mass in the right orbit, severe proptosis, producing severe disfigurement. The diagnosis of orbital teratoma was confirmed by clinical, image, and histopathological exams. To the authors best knowledge this is the first case of orbital teratoma in Brazilian literature reporting a case where the diagnosis was made in utero, at 24 + 4 weeks of gestation.
The association of visceral adiposity with handgrip strength in community dwellers of the United Arab Emirates
Authors: Alshouraa Ahmad Alli , Darweesh Ahmed Mohammad , Yaser Yazan Mazen , Abazid Eelaf Wael , Alshamsi Alya Kattarah , Kannas Samah Mohamed , Abbara Mohamad , Otour Ahmad Haitham , Qaisar Rizwan , Khalid Amna
Published: February 2023

Background:

Handgrip strength (HGS) is a powerful tool to assess generalized body health; however, its association with visceral adipose tissues (VATs) in the community dwellers of the United Arab Emirates (UAE) is not known. The objectives of this study were to investigate the association between HGS and VATs in the UAE population of both genders, 18–65 years of age (n = 1146).

Methods:

This is a cross-sectional study conducted in various community centers of the UAE from June to October 2021. We used a handgrip dynamometer to measure HGS and a bioelectrical impedance scale to measure body composition, including VAT content. VAT was categorized into low (1–9), optimal (10–14), and high (15–30) levels. We used t-test and ANOVA analyses to measure differences in HGS and VAT across gender and age groups.

Results:

The peak HGS was found in the third and fourth decades of life, followed by an age-associated decline. We report that the highest HGS for dominant was found in people with the optimal VATs content irrespective of gender and age. Conversely, having low or high VATs was associated with lower HGS. However, there were no differences between the HGS of dominant versus nondominant hands in men and women.

Conclusion:

Altogether, we report an association of an optimal VAT content with peak HGS, so that having low or high VATs were associated with reduced HGS. Taken together, the measurements of VAT and HGS may be helpful in assessing generalized health in preclinical settings.
Isolation, characterization, and molecular identification of probiotics showing promising hypoglycemia operating activities
Authors: Hegazy Abdel-Whhab A. , El-Waseif Amr A. , Maany Dina A.
Published: February 2023

Background

Probiotics are the most useful microorganisms for animal and human health; they are used in the pharmaceutical and food industries for many products that enhance digestion and immunity.

Objective

The objective of our study was to isolate, characterize, and identify a probiotic bacterial strain and determine its hypoglycemia operating parameters.

Materials and methods

Our research was carried out through the isolation of probiotic colonies from milk samples on MRS medium. Bacterial isolates were characterized both morphologically and biochemically. The collected bacterial isolates were tested for their low pH tolerance on phosphate buffer pH 2.0 and bile salt tolerance in MRS-THIO liquid medium. Glucose assimilation activity was tested by measuring the residual glucose concentration on MRS liquid medium at 37°C after 24 and 48 h by GOD-PAP enzymatic colorimetric method. The initial glucose concentration was 500 mg/dl. The most potent isolate was identified by methods of 16S-rDNA sequencing.

Results and conclusion

Twenty-one bacterial isolates were isolated and characterized. Bacterial isolates showed the highest resistance to acidic pH 2.0 and they were bile-tolerant. Results of glucose assimilation showed that there was a marked increase in sugar consumption rate after 48 h more than 24 h in most of the bacterial isolates. The top 10 isolates were selected for the testing of the rest of the parameters. Results show that no noticeable differences were observed in the consumption of glucose in the low-glucose concentration, but with more glucose concentration more glucose consumption rate differences were recorded among organisms. The top two organisms that have the ability to reproduce and consume glucose even in high-glucose concentrations were Ab 9 and Ab 2 with results of glucose residual concentration of 108 and 124 mg/dl, respectively. The phylogenetic tree showed that the most potent isolate Ab 2 was identified as Lactobacillus brevis.
A rare invasive male breast cancer of nonspecific type presenting at a primary care clinic: Importance of early diagnosis and management
Authors: Mansoor Nurulhana S. , Arifin Farnaza , Kornain Noor K.M. , Razalli Mazuin M.
Published: February 2023

Male breast cancer is a rare disease with an incidence rate of <1% of all breast cancer cases, and only 1% of all male malignancies. Men tend to present at an older age and with more advanced stages compared to women. We report a case of a 74-year-old man who presented at a primary care clinic with a right subareolar painless breast mass. A mammogram and core biopsy were performed. A diagnosis of right invasive breast carcinoma was rendered. The patient underwent a right total mastectomy with ipsilateral axillary lymph node dissection, which revealed an invasive ductal carcinoma of no special type (NST). Chemotherapy, radiotherapy, and hormonal therapy were included in the adjuvant treatment plan. In this report, we discuss the important role of the primary care physician (PCP) in early diagnosis and referral for definitive management. The PCP also plays an essential role in the holistic care of male breast cancer patients, including the management of physical, psychological, social, and underlying chronic diseases.