bluuebunny/crossref_metadata_2025 huggingface dataset:
Hardware Implementation for an Improved Full-Pixel Search Algorithm Based on Normalized Cross Correlation Method
Authors: Zhang Guohe , Kuang Zejie , Wei Sufen , Huang Kai , Liang Feng , Yang Cheng-Fu
Published: December 2018

Digital speckle correlation method is widely used in the areas of three-dimensional deformation and morphology measurement. It has the advantages of non-contact, high precision, and strong stability. However, it is very complex to be carried out with low speed software implementation. Here, an improved full pixel search algorithm based on the normalized cross correlation (NCC) method considering hardware implementation is proposed. According to the field programmable gate array (FPGA) simulation results, the speed of hardware design proposed in this paper is 2000 faster than that of software in single point matching, and 600 times faster than software in multi-point matching. The speed of the presented algorithm shows an increasing trend with the increase of the template size when performing multipoint matching.
Data-Adaptive Coherent Demodulator for High Dynamics Pulse-Wave Ultrasound Applications
Authors: Ricci Stefano , Meacci Valentino
Published: December 2018

Pulse-Wave Doppler (PWD) ultrasound has been applied to the detection of blood flow for a long time; recently the same method was also proven effective in the monitoring of industrial fluids and suspensions flowing in pipes. In a PWD investigation, bursts of ultrasounds at 0.5–10 MHz are periodically transmitted in the medium under test. The received signal is amplified, sampled at tens of MHz, and digitally processed in a Field Programmable Gate Array (FPGA). First processing step is a coherent demodulation. Unfortunately, the weak echoes reflected from the fluid particles are received together with the echoes from the high-reflective pipe walls, whose amplitude can be 30–40 dB higher. This represents a challenge for the input dynamics of the system and the demodulator, which should clearly detect the weak fluid signal while not saturating at the pipe wall components. In this paper, a numerical demodulator architecture is presented capable of auto-tuning its internal dynamics to adapt to the feature of the actual input signal. The proposed demodulator is integrated into a system for the detection of the velocity profile of fluids flowing in pipes. Simulations and experiments with the system connected to a flow-rig show that the data-adaptive demodulator produces a noise reduction of at least of 20 dB with respect to different approaches, and recovers a correct velocity profile even when the input data are sampled at 8 bits only instead of the typical 12–16 bits.
Non-CpG Methylation Revised
Authors: Fuso Andrea
Published: December 2018

Textbook and scientific papers addressing DNA methylation usually still cite “DNA methylation occurs at CpG cytosines”. Methylation at cytosines outside the CpG nucleotide, the so-called “non-CpG methylation”, is usually considered a minor and not biologically relevant process. However, the technical improvements and additional studies in epigenetics have demonstrated that non-CpG methylation is present with frequency higher than previously thought and retains biological activity, potentially relevant to the understanding and the treatment of human diseases.
Current and Potential Spatial Distribution of Six Endangered Pine Species of Mexico: Towards a Conservation Strategy
Authors: Romero-Sanchez Martin Enrique , Perez-Miranda Ramiro , Gonzalez-Hernandez Antonio , Velasco-Garcia Mario Valerio , Velasco-Bautista Efraín , Flores Andrés
Published: December 2018

Mexico is home to the highest species diversity of pines: 46 species out of 113 reported around the world. Within the great diversity of pines in Mexico, Pinus culminicola Andresen et Beaman, P. jaliscana Perez de la Rosa, P. maximartinenzii Rzed., P. nelsonii Shaw, P. pinceana Gordon, and P. rzedowskii Madrigal et M. Caball. are six catalogued as threatened or endangered due to their restricted distribution and low population density. Therefore, they are of special interest for forest conservation purposes. In this paper, we aim to provide up-to-date information on the spatial distribution of these six pine species according to different historical registers coming from different herbaria distributed around the country by using spatial modeling. Therefore, we recovered historical observations of the natural distribution of each species and modelled suitable areas of distribution according to environmental requirements. Finally, we evaluated the distributions by contrasting changes of vegetation in the period 1991–2016. The results highlight areas of distribution for each pine species in the northeast, west, and central parts of Mexico. The results of this study are intended to be the basis of in situ and ex situ conservation strategies for the endangered Mexican pines.
Spatial Pattern and Competitive Relationships of Moso Bamboo in a Native Subtropical Rainforest Community
Authors: Zhang Haonan , Xue Jianhui
Published: December 2018

Bamboo has invaded native forests worldwide, and its aggressive spread by rhizomes facilitates patch expansion and the eventual replacement of adjacent forests. However, fine-scale studies of the spatial pattern and competitive relationships of bamboo in native forests are still lacking. We obtained data from nine plots in a native south subtropical rainforest in Guizhou Province, northwest China. Pair-correlation functions indicated that competition caused by bamboo expansion has not led to large-scale regular spatial distributions in bamboo forest and negative density-related dependence mechanisms regulating the spatial pattern of the native forest community. Marked correlation functions indicated small bamboo in clusters form colony patches that grow around the larger mature trees, resulting in patch expansion in the native forest community. Mark variogram functions identified significant positive spatial autocorrelation of moso bamboo caused by interactions with similar-sized trees within colony patches. This study showed that moso bamboo has colonized and expanded within the native forest community. Compared to the native forest species, the strategy of patch expansion and equal tree sizes in colony patches of moso bamboo could prevent regular distribution trend and size-asymmetric competition between nearby bamboo for the asymmetric and limited sources (i.e., light) in the forest, enhancing the persistence of moso bamboo in the native forest in our study stand located in a south subtropical rainforest in a river valley.
Contemporary Fire Regimes of the Arid Carnarvon Basin Region of Western Australia
Authors: Ladbrook Megan , J. B. van Etten Eddie , D. Stock William
Published: December 2018

This study investigates the fire regime for the arid Carnarvon Basin region of Western Australia using remotely sensed imagery. A fire history database was constructed from satellite images to characterise the general fire regime and determine any effect of vegetation types and pre-fire weather and climate. The study area was divided into two sections (northern and southern) due to their inherently different vegetation and climate. A total of 23.8% (15,646 km2) of the study area was burnt during the 39-year study period. Heathland vegetation (54%) burnt the most extensively in the southern study area, and hummock grasslands (68%) in the northern. A single, unusually large fire in 2012 followed exceptional rains in the previous 12 months and accounted for 55% of the total burnt area. This fire burnt mainly through Acacia shrublands and woodlands rather than hummock grasslands, as normally experienced in the northern study area. Antecedent rainfall and fire weather were found to be the main meteorological factors driving fire size. Both study areas showed a moderate to strong correlation between fire size and increased pre-fire rainfall in the year preceding the fire. Predicted future changes in climate may lead to more frequent and higher intensity fires.
New Insights on the Role of Urea on the Dissolution and Thermally-Induced Gelation of Cellulose in Aqueous Alkali
Authors: Alves Luis , Medronho Bruno , Filipe Alexandra , E. Antunes Filipe , Lindman Björn , Topgaard Daniel , Davidovich Irina , Talmon Yeshayahu
Published: December 2018

The gelation of cellulose in alkali solutions is quite relevant, but still a poorly understood process. Moreover, the role of certain additives, such as urea, is not consensual among the community. Therefore, in this work, an unusual set of characterization methods for cellulose solutions, such as cryo-transmission electronic microscopy (cryo-TEM), polarization transfer solid-state nuclear magnetic resonance (PTssNMR) and diffusion wave spectroscopy (DWS) were employed to study the role of urea on the dissolution and gelation processes of cellulose in aqueous alkali. Cryo-TEM reveals that the addition of urea generally reduces the presence of undissolved cellulose fibrils in solution. These results are consistent with PTssNMR data, which show the reduction and in some cases the absence of crystalline portions of cellulose in solution, suggesting a pronounced positive effect of the urea on the dissolution efficiency of cellulose. Both conventional mechanical macrorheology and microrheology (DWS) indicate a significant delay of gelation induced by urea, being absent until ca. 60 °C for a system containing 5 wt % cellulose, while a system without urea gels at a lower temperature. For higher cellulose concentrations, the samples containing urea form gels even at room temperature. It is argued that since urea facilitates cellulose dissolution, the high entanglement of the cellulose chains in solution (above the critical concentration, C*) results in a strong three-dimensional network.
Chromatin as a Platform for Modulating the Replication Stress Response
Authors: Fournier Louis-Alexandre , Kumar Arun , Stirling Peter C.
Published: December 2018

Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances in our understanding of histone supply, histone recycling and nascent histone incorporation during replication. Furthermore, much is now known about the roles of histone remodellers and post-translational modifications in replication. It has also become clear that nucleosome dynamics during replication play critical roles in genome maintenance and that chromatin modifiers are important for preventing DNA replication stress. An understanding of how cells deploy specific nucleosome modifiers, chaperones and remodellers directly at sites of replication fork stalling has been building more slowly. Here we will specifically discuss recent advances in understanding how chromatin composition contribute to replication fork stability and restart.
The Unresolved Problem of DNA Bridging
Authors: Fernández-Casañas María , Chan Kok-Lung
Published: December 2018

Accurate duplication and transmission of identical genetic information into offspring cells lies at the heart of a cell division cycle. During the last stage of cellular division, namely mitosis, the fully replicated DNA molecules are condensed into X-shaped chromosomes, followed by a chromosome separation process called sister chromatid disjunction. This process allows for the equal partition of genetic material into two newly born daughter cells. However, emerging evidence has shown that faithful chromosome segregation is challenged by the presence of persistent DNA intertwining structures generated during DNA replication and repair, which manifest as so-called ultra-fine DNA bridges (UFBs) during anaphase. Undoubtedly, failure to disentangle DNA linkages poses a severe threat to mitosis and genome integrity. This review will summarize the possible causes of DNA bridges, particularly sister DNA inter-linkage structures, in an attempt to explain how they may be processed and how they influence faithful chromosome segregation and the maintenance of genome stability.
Implementation of a Fracture Modeling Strategy Based on Georadar Survey in a Large Area of Limestone Quarry Bench
Authors: Elkarmoty Mohamed , Tinti Francesco , Kasmaeeyazdi Sara , Giannino Fabio , Bonduà Stefano , Bruno Roberto
Published: December 2018

Rock mass fractures adversely affect the cutting of commercial-size blocks and cause rock material loss in ornamental stone quarries. In order to obtain a reliable evaluation and an optimized production of ornamental stone deposits, it is fundamental to detect fractures in a non-destructive manner identifying them through 3D deterministic modeling. In this study, a recently published fracture modeling strategy, based on Ground Penetrating Radar (GPR) survey was implemented on a large area of bench (27.0 m × 65.0 m) in a limestone quarry in Italy. The survey was done using a dual-frequency GPR system (250 MHz and 700 MHz). The objective of this work was to investigate the large-scale applicability of the mentioned fracture model for future consideration in quarrying optimization studies. Only the 700 MHz radargrams were considered for the fracture modeling, as they provided a higher resolution than the 250 MHz radargrams and a penetration depth of about 4.0 m. The bulk dielectric constant of the rock mass of the bench was estimated by averaging the velocities obtained from fitting the hyperbolic diffractions of fractures at different depths. The model showed that fractures from the same family set can have noticeable spatial variations. The results allowed us to roughly estimate the sizes of the blocks exploitable from the different rock layers of the quarry bench.
Sequestering Atmospheric CO2 Inorganically: A Solution for Malaysia’s CO2 Emission
Authors: Jorat M. Ehsan , Aziz Maniruzzaman A. , Marto Aminaton , Zaini Nabilah , Jusoh Siti Norafida , Manning David A.C.
Published: December 2018

Malaysia is anticipating an increase of 68.86% in CO2 emission in 2020, compared with the 2000 baseline, reaching 285.73 million tonnes. A major contributor to Malaysia’s CO2 emissions is coal-fired electricity power plants, responsible for 43.4% of the overall emissions. Malaysia’s forest soil offers organic sequestration of 15 tonnes of CO2 ha−1·year−1. Unlike organic CO2 sequestration in soil, inorganic sequestration of CO2 through mineral carbonation, once formed, is considered as a permanent sink. Inorganic CO2 sequestration in Malaysia has not been extensively studied, and the country’s potential for using the technique for atmospheric CO2 removal is undefined. In addition, Malaysia produces a significant amount of solid waste annually and, of that, demolition concrete waste, basalt quarry fine, and fly and bottom ashes are calcium-rich materials suitable for inorganic CO2 sequestration. This project introduces a potential solution for sequestering atmospheric CO2 inorganically for Malaysia. If lands associated to future developments in Malaysia are designed for inorganic CO2 sequestration using demolition concrete waste, basalt quarry fine, and fly and bottom ashes, 597,465 tonnes of CO2 can be captured annually adding a potential annual economic benefit of €4,700,000.
Alongshore Variability in the Response of a Mixed Sand and Gravel Beach to Bimodal Wave Direction
Authors: Atkinson John , Esteves Luciana S.
Published: December 2018

Characterising spatial and temporal variations in coastal behaviour is essential for the management of beach systems. Recent studies have shown that beach response is more complex in coasts subjected to bimodal wave directions. Despite being pervasive at higher latitudes, relatively little is known about the spatial variability in the response of mixed sand and gravel beaches. This work presents evidence that the response of mixed sand and gravel beaches to bimodal wave directions can be highly variable (both in magnitude and direction of change) even within short shoreline stretches. The analyses focused on beach topography data collected between 2009 and 2018 along five cross-shore transects within a 2-km-long shoreline in Suffolk (East England) and offshore wave data recorded at the West Gabbard Smart buoy. The dominant offshore wave direction oscillates between the southwest and the northeast from year to year, and the bimodal beach sediment has modes at 0.35 mm and 16 mm. Analyses were undertaken considering two timeframes: Biannual surveys from January 2009 to February 2018, and more intensive surveying (from seasonal to pre- and post-storm) from July 2016 to March 2018. Results highlighted large differences in beach response even between transects 350 m apart and no clear seasonal pattern of change. Instead, response seemed to depend on a complex interaction between wave power, dominant wave direction, and local settings. Although correlations were identified between indicators of beach change and wave conditions, these varied across transects. Divergence of longshore transport may occur locally, likely influencing the high alongshore variability.
Whole Genome Resequencing from Bulked Populations as a Rapid QTL and Gene Identification Method in Rice
Authors: Zegeye Workie Anley , Zhang Yingxin , Cao Liyong , Cheng Shihua
Published: December 2018

Most Quantitative Trait Loci (QTL) and gene isolation approaches, such as positional- or map-based cloning, are time-consuming and low-throughput methods. Understanding and detecting the genetic material that controls a phenotype is a key means to functionally analyzing genes as well as to enhance crop agronomic traits. In this regard, high-throughput technologies have great prospects for changing the paradigms of DNA marker revealing, genotyping, and for discovering crop genetics and genomic study. Bulk segregant analysis, based on whole genome resequencing approaches, permits the rapid isolation of the genes or QTL responsible for the causative mutation of the phenotypes. MutMap, MutMap Gap, MutMap+, modified MutMap, and QTL-seq methods are among those approaches that have been confirmed to be fruitful gene mapping approaches for crop plants, such as rice, irrespective of whether the characters are determined by polygenes. As a result, in the present study we reviewed the progress made by all these methods to identify QTL or genes in rice.
Melatonin Improves Parthenogenetic Development of Vitrified–Warmed Mouse Oocytes Potentially by Promoting G1/S Cell Cycle Progression
Authors: Pan Bo , Yang Haoxuan , Wu Zhenzheng , Qazi Izhar Hyder , Liu Guoshi , Han Hongbing , Meng Qingyong , Zhou Guangbin
Published: December 2018

This study aimed to investigate the effect of melatonin on the cell cycle of parthenogenetic embryos derived from vitrified mouse metaphase II (MII) oocytes. Fresh oocytes were randomly allocated into three groups: untreated (control), or vitrified by the open-pulled straw method without (Vitrification group) or with melatonin (MT) supplementation (Vitrification + MT group). After warming, oocytes were parthenogenetically activated and cultured in vitro, then the percentage of embryos in the G1/S phase, the levels of reactive oxygen species (ROS) and glutathione (GSH), and the mRNA expression of cell cycle-related genes (P53, P21 and E2F1) in zygotes and their subsequent developmental potential in vitro were evaluated. The results showed that the vitrification/warming procedures significantly decreased the frequency of the S phase, markedly increased ROS and GSH levels and the expression of P53 and P21 genes, and decreased E2F1 expression in zygotes at the G1 stage and their subsequent development into 2-cell and blastocyst stage embryos. However, when 10−9 mol/L MT was administered for the whole duration of the experiment, the frequency of the S phase in zygotes was significantly increased, while the other indicators were also significantly improved and almost recovered to the normal levels shown in the control. Thus, MT might promote G1-to-S progression via regulation of ROS, GSH and cell cycle-related genes, potentially increasing the parthenogenetic development ability of vitrified–warmed mouse oocytes.
DA-9701 (Motilitone): A Multi-Targeting Botanical Drug for the Treatment of Functional Dyspepsia
Authors: Jin Mirim , Son Miwon
Published: December 2018

Functional dyspepsia (FD) is the most common functional gastrointestinal disorder (FGID). FD is characterized by bothersome symptoms such as postprandial fullness, early satiety, and epigastric pain or burning sensations in the upper abdomen. The complexity and heterogeneity of FD pathophysiology, which involves multiple mechanisms, make both treatment and new drug development for FD difficult. Current medicines for FD targeting a single pathway have failed to show satisfactory efficacy and safety. On the other hand, multicomponent herbal medicines that act on multiple targets may be a promising alternative treatment for FD. DA-9701 (Motilitone), a botanical drug consisting of Corydalis Tuber and Pharbitidis Semen, has been prescribed for FD since it was launched in Korea in 2011. It has multiple mechanisms of action such as prokinetic effects, fundus relaxation, and visceral analgesia, which are mediated by dopamine D2 and several serotonin receptors involved in gastrointestinal (GI) functions. In clinical studies, DA-9701 has been found to be beneficial for improvement of FD symptoms and GI functions in FD patients, while showing better safety compared to that associated with conventional medicines. In this review, we provide updated information on the pharmacological effects, safety, and clinical results of DA-9701 for the treatment of FGIDs.
Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation
Authors: Audira Gilbert , Sarasamma Sreeja , Chen Jung-Ren , Juniardi Stevhen , Sampurna Bonifasius , Liang Sung-Tzu , Lai Yu-Heng , Lin Geng-Ming , Hsieh Ming-Chia , Hsiao Chung-Der
Published: December 2018

Leptin, a hormone secreted by peripheral adipose tissues, regulates the appetite in animals. Recently, evidence has shown that leptin also plays roles in behavioral response in addition to controlling appetite. In this study, we examined the potential function of leptin on non-appetite behaviors in zebrafish model. By using genome editing tool of Transcription activator-like effector nuclease (TALEN), we successfully knocked out leptin a (lepa) gene by deleting 4 bp within coding region to create a premature-translation stop. Morphological and appetite analysis showed the lepa KO fish display a phenotype with obese, good appetite and elevation of Agouti-related peptide (AgRP) and Ghrelin hormones, consistent with the canonical function of leptin in controlling food intake. By multiple behavior endpoint analyses, including novel tank, mirror biting, predator avoidance, social interaction, shoaling, circadian rhythm, and color preference assay, we found the lepa KO fish display an anxiogenic phenotype showing hyperactivity with rapid swimming, less freezing time, less fear to predator, loose shoaling area forming, and circadian rhythm and color preference dysregulations. Using biochemical assays, melatonin, norepinephrine, acetylcholine and serotonin levels in the brain were found to be significantly reduced in lepa KO fish, while the levels of dopamine, glycine and cortisol in the brain were significantly elevated. In addition, the brain ROS level was elevated, and the anti-oxidative enzyme catalase level was reduced. Taken together, by performing loss-of-function multiple behavior endpoint testing and biochemical analysis, we provide strong evidence for a critical role of lepa gene in modulating anxiety, aggression, fear, and circadian rhythm behaviors in zebrafish for the first time.
Selenium-Enriched Brushite: A Novel Biomaterial for Potential Use in Bone Tissue Engineering
Authors: Laskus Aleksandra , Zgadzaj Anna , Kolmas Joanna
Published: December 2018

In this study, a novel biomaterial, i.e., brushite containing 0.67 wt% of selenium (Se-Bru) was synthesized via a wet precipitation method. Pure, unsubstituted brushite (Bru) was synthesized via the same method and used as a reference material. Different techniques of instrumental analysis were applied to investigate and compare physicochemical properties of both materials. Fourier-Transform Infrared Spectroscopy confirmed the chemical identity of both materials. Scanning Electron Microscopy (SEM) was used to study the morphology and indicated that both samples (Bru and Se-Bru) consisted of plate-like microcrystals. Powder X-ray Diffraction (PXRD) showed that Bru, as well as Se-Bru were crystallographically homogenous. What is more, the data obtained from PXRD studies revealed that the substitution of selenite ions into the crystal structure of the material had clearly affected its lattice parameters. The incorporation of selenium was also confirmed by solid-state 1H→31P CP MAS kinetics experiments. Additionally, studies on the release kinetics of the elements forming Se-Bru and preliminary cytotoxicity tests were conducted. This preliminary research will favor a better understanding of ionic substitution in calcium phosphates and may be a starting point for the development of selenium-doped brushite cements for potential use in bone tissue impairments treatment.
An Automated Technique for Extracting Phasors from Protective Relay’s Event Reports
Authors: Navalpakkam Ananthan Sundaravaradan , Furlani Bastos Alvaro , Santoso Surya , Del Rosso Alberto
Published: December 2018

Post-fault event report analysis is a crucial skill set for electric power engineers in the protection industry. This paper serves as a reference which elucidates the preprocessing procedures involved in transforming data present in event reports to phasors that can be used in various post-fault analysis application algorithms. The paper discusses key elements of this process such as interpreting the data and calculating voltage and current phasors from instantaneous sample values present in a fault record. A crucial component of event report analysis is choosing the appropriate time instant for calculating phasors for event report analysis. Conventionally, protection engineers manually perform event report analysis and arbitrarily select time instants after certain cycles of fault inception for this purpose. This approach prevents the process from being successfully automated. Furthermore, arbitrary selection of time instant does not utilize the entire fault data and may fail in several cases such as short time fault scenario and evolving fault scenario. For this purpose, this paper proposes an adaptive novel technique which utilizes the entire data present in the event report to select the most suitable time instant for event report analysis. The superiority of the proposed algorithm over conventional methods is demonstrated using three real-world scenarios.
Association between Hemoglobin and Hemoglobin A1c: A Data-Driven Analysis of Health Checkup Data in Japan
Authors: Takeuchi Masato , Kawakami Koji
Published: December 2018

Background: Interpretation of hemoglobin A1c (HbA1c) levels may be confounded by spurious results in anemic persons, but its degree is not well-established. Methods: We used an employer-based health insurance database, containing health checkup data and medical claims data; both were linked via a unique identifier of each beneficiary. This study included persons aged 18–75 years who participated in health checkups, with a confirmed or suspected diagnosis of diabetes. The relationship between hemoglobin (Hb) and HbA1c is shown in a spline curve using a machine learning technique accounting for patient factors and within-person correlations. Spline curves were also shown in several sub-populations. Results: Overall, a decreased Hb value was associated with a lower HbA1c value, but the extent differed among populations. In the whole cohort of the type-2 diabetes group (55,420 persons), the curve was generally a plateau in the persons with a Hb value <120–130 g/L. Among the 18,478 persons with HbA1c around 48 mmol/mol, we observed a liner trend. Among the current glucose-lowering medication users (6253 persons), we found a right upward curve. Conclusions: The relationship between Hb and HbA1c may not be straightforward, varying among populations of different clinical interest. Our results indicate that a simple formulation between the Hb and HbA1c values is unlikely.
Tarsal Tunnel Mechanosensitivity Is Increased in Patients with Asthma: A Case-Control Study
Authors: Calvo-Lobo César , Painceira-Villar Roi , López-López Daniel , García-Paz Vanesa , Becerro-de-Bengoa-Vallejo Ricardo , Losa-Iglesias Marta Elena , Palomo-López Patricia
Published: December 2018

Background: Based on changes in lung function and musculoskeletal disorders in patients with asthma, this study aimed to compare the tarsal tunnel and fibular bone pressure pain thresholds (PPTs) of patients with asthma and healthy matched-paired controls. Methods: A case-control study was performed. One hundred participants were recruited: 50 asthma patients and 50 healthy matched-paired controls. Bilaterally, tarsal tunnel and fibula bone PPTs were registered. Results: Statistically significant differences (p < 0.01) were shown bilaterally for tarsal tunnel PPT. With the exception of fibula PPT (p > 0.05), asthma patients presented less tarsal tunnel PPT than healthy participants. Statistically significant differences (p < 0.05) were shown for two linear regression prediction models of the right (R2 = 0.279) and left (R2 = 0.249) tarsal tunnels PPTs as dependent variables, and based on sex, group, contralateral tarsal tunnel PPT and ipsilateral fibula PPT as independent variables. Conclusions: The study findings showed that a bilateral tarsal tunnel mechanosensitivity increase is exhibited in patients diagnosed with asthma. The presence of asthma may bilaterally predict the PPT of tarsal tunnel. These findings may suggest the presence of central sensitization in asthma patients, which could clinically predispose them to musculoskeletal disorders, such as tarsal tunnel syndrome.
Examining the Association and Directionality between Mental Health Disorders and Substance Use among Adolescents and Young Adults in the U.S. and Canada—A Systematic Review and Meta-Analysis
Authors: Esmaeelzadeh Sarvenaz , Moraros John , Thorpe Lilian , Bird Yelena
Published: December 2018

Background: The purpose of this systematic review was to examine the association and directionality between mental health disorders and substance use among adolescents and young adults in the U.S. and Canada. Methods: The following databases were used: Medline, PubMed, Embase, PsycINFO, and Cochrane Library. Meta-analysis used odds ratios as the pooled measure of effect. Results: A total of 3656 studies were screened and 36 were selected. Pooled results showed a positive association between depression and use of alcohol (odds ratio (OR) = 1.50, 95% confidence interval (CI): 1.24–1.83), cannabis (OR = 1.29, 95% CI: 1.10–1.51), and tobacco (OR = 1.65, 95% CI: 1.43–1.92). Significant associations were also found between anxiety and use of alcohol (OR = 1.54, 95% CI: 1.19–2.00), cannabis (OR = 1.36, 95% CI: 1.02–1.81), and tobacco (OR = 2.21, 95% CI: 1.54–3.17). A bidirectional relationship was observed with tobacco use at baseline leading to depression at follow-up (OR = 1.87, CI = 1.23–2.85) and depression at baseline leading to tobacco use at follow-up (OR = 1.22, CI = 1.09–1.37). A unidirectional relationship was also observed with cannabis use leading to depression (OR = 1.33, CI = 1.19–1.49). Conclusion: This study offers insights into the association and directionality between mental health disorders and substance use among adolescents and young adults. Our findings can help guide key stakeholders in making recommendations for interventions, policy and programming.
Current Research and New Perspectives of Telemedicine in Chronic Heart Failure: Narrative Review and Points of Interest for the Clinician
Authors: Andrès Emmanuel , Talha Samy , Zulfiqar Abrar-Ahmad , Hajjam Mohamed , Ervé Sylvie , Hajjam Jawad , Gény Bernard , Hajjam El Hassani Amir
Published: December 2018

Background: This is a narrative review of both the literature and Internet pertaining to telemedicine projects within the field of heart failure, with special attention placed on remote monitoring of second-generation projects and trials, particularly in France. Results: Since the beginning of the 2000’s, several telemedicine projects and trials focused on chronic heart failure have been developed. The first telemedicine projects (e.g., TEN-HMS, BEAT-HF, Tele-HF, and TIM-HF) primarily investigated telemonitoring or for the older ones, telephone follow-up. Numerous second-generation telemedicine projects have emerged in Europe over the last ten years or are still under development for computer science heart failure, especially in Europe, such as SCAD, OSICAT, E-care, PRADO-INCADO, and TIM-HF2. The E-care telemonitoring project fits within the telemedicine 2.0 framework, based on connected objects, new information and communication technologies (ICT) and Web 2.0 technologies. E-care is the first telemedicine project including artificial intelligence (AI). TIM-HF2 is the first positive prospective randomized study with regards to EBM with positive significant clinical benefit, in terms of unplanned cardiovascular hospital admissions and all-cause deaths. The potential contribution of second-generation telemedicine projects in terms of mortality, morbidity, and number of hospitalizations avoided is currently under study. Their impact in terms of health economics is likewise being investigated, taking into account that the economic and social benefits brought up by telemedicine solutions were previously validated by the original telemedicine projects.
Effect of Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Patients with Nail Psoriasis
Authors: Krajewska-Włodarczyk Magdalena , Owczarczyk-Saczonek Agnieszka , Placek Waldemar , Wojtkiewicz Maja , Wojtkiewicz Joanna
Published: December 2018

To assess the effect of methotrexate on the development of distal interphalangeal joint extensor tendon enthesopathy in psoriasis, thirty-two people aged 34 to 57 years with nail psoriasis and distal interphalangeal joint extensor tendon enthesopathy (19 patients with Ps (psoriasis) and 13 with PsA (psoriatic arthritis) were started on methotrexate at 15 to 25 mg/week and the treatment was continued for 6 months). A total of 319 nails were examined. After six months of treatment, the thicknesses of the nail plate, nail bed and nail matrix were found to decrease in both groups of patients. Methotrexate treatment resulted in a decrease in the joint extensor tendon thickness only in patients with Ps (0.94 ± 0.05 vs. 0.96 ± 0.04, p < 0.001), where the tendon thickness after treatment correlated with the matrix thickness (r = 0.337, p = 0.018) and with the bed thickness (r = 0.299, p = 0.039). Methotrexate treatment resulted in a decrease in the extensor tendon thickness only in patients with Ps but not in PsA. The findings of this study may suggest the effectiveness of systemic treatment of nail psoriasis in patients without arthritis and the use of US nail examinations in Ps and PsA patients in morphological change assessment and response to treatment.
Hyperbaric Oxygen Therapy Enhanced Circulating Levels of Endothelial Progenitor Cells and Angiogenesis Biomarkers, Blood Flow, in Ischemic Areas in Patients with Peripheral Arterial Occlusive Disease
Authors: Lin Pao-Yuan , Sung Pei-Hsun , Chung Sheng-Ying , Hsu Shan-Ling , Chung Wen-Jung , Sheu Jiunn-Jye , Hsueh Shu-Kai , Chen Kuan-Hung , Wu Re-Wen , Yip Hon-Kan
Published: December 2018

Background: This study tested the hypothesis that hyperbaric oxygen (HBO) therapy enhanced the circulating levels of endothelial progenitor cells (EPCs), soluble angiogenesis factors, and blood flow in ischemic areas in patients with peripheral arterial occlusive disease (PAOD). Methods: In total, 57 consecutive patients with PAOD undergoing the HBO therapy (3 atmospheres (atm) for 2 h each time) were prospectively enrolled into the present study. Venous blood sampling was performed to assess the circulating levels of EPCs and soluble angiogenesis factors prior to and during five sessions of HBO therapy. Additionally, skin perfusion pressure (SPP), an indicator of blood flow in ischemic areas, was measured by moorVMS-PRES. Results: The results demonstrated that the circulating levels of EPCs (cluster of differentiation (CD)34+/CD133+/CD45dim, CD31+/CD133+/CD45dim, CD34+) and soluble angiogenesis factors—vascular endothelial growth factor/stromal cell-derived factor 1/hepatocyte growth factor/fibroblast growth factor (VEGF/SDF-1α/HGF/FGF) were significantly increased post-HBO therapy as compared to pre-HBO therapy (all p < 0.01). Additionally, Matrigel assay showed that the angiogenesis was significantly increased in post-HBO therapy as compared to prior to therapy (p < 0.001). Furthermore, SPP was significantly increased in the ischemic area (i.e., plantar foot and mean SPP of the ischemic foot) in post-HBO therapy as compared to pre-HBO therapy (all p < 0.01). Importantly, the HBO therapy did appear to result in complications, and all the patients were uneventfully discharged without amputation. Conclusions: HBO therapy augmented circulating levels of EPCs and angiogenesis factors, and improved the blood flow in the ischemic area.
The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning
Authors: Shin Hanna , Reiner David J.
Published: December 2018

EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to assume a precise array of three cell fates with high fidelity. A group of core and modulatory signaling cascades forms a signaling network that demonstrates plasticity during the transition from naïve to terminally differentiated cells. In this review, we summarize the history of classical developmental manipulations and molecular genetics experiments that led to our understanding of the signals governing this process, and discuss principles of signal transduction and developmental biology that have emerged from these studies.
Anti-Candida albicans Activity of Thiazolylhydrazone Derivatives in Invertebrate and Murine Models
Authors: Cruz Lana Ivone Barreto , Lopes Larissa Ferreira Finamore , De Camargo Ribeiro Felipe , De Sá Nívea Pereira , Lino Cleudiomar Inácio , Tharmalingam Nagendran , De Oliveira Renata Barbosa , Rosa Carlos Augusto , Mylonakis Eleftherios , Fuchs Beth Burgwyn , Johann Susana
Published: December 2018

Candidiasis is an opportunistic fungal infection with Candida albicans being the most frequently isolated species. Treatment of these infections is challenging due to resistance that can develop during therapy, and the limited number of available antifungal compounds. Given this situation, the aim of this study was to evaluate the antifungal activity of four thiazolylhydrazone compounds against C. albicans. Thiazolylhydrazone compounds 1, 2, 3, and 4 were found to exert antifungal activity, with MICs of 0.125–16.0 μg/mL against C. albicans. The toxicity of the compounds was evaluated using human erythrocytes and yielded LC50 > 64 μg/mL. The compounds were further evaluated using the greater wax moth Galleria mellonella as an in vivo model. The compounds prolonged larval survival when tested between 5 and 15 mg/kg, performing as well as fluconazole. Compound 2 was evaluated in murine models of oral and systemic candidiasis. In the oral model, compound 2 reduced the fungal load on the mouse tongue; and in the systemic model it reduced the fungal burden found in the kidney when tested at 10 mg/kg. These results show that thiazolylhydrazones are an antifungal towards C. albicans with in vivo efficacy.
Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1)
Authors: Bokelmann Kristin , Brockmöller Jürgen , Tzvetkov Mladen V.
Published: December 2018

The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine. OCT1 expression is inter-individually highly variable. Here, we analyzed SNPs in the OCT1 promoter concerning their potential contribution to the variability in OCT1 expression. Using electrophoretic mobility shift and luciferase reporter gene assays in HepG2, Hep3B, and Huh7 cell lines, we identified the SNPs −1795G>A (rs6935207) and −201C>G (rs58812592) as having effects on transcription factor binding and/or promoter activity. The A-allele of the −1795G>A SNP showed allele-specific binding of the transcription factor NF-Y leading to 2.5-fold increased enhancer activity of the artificial SV40 promoter. However, the −1795G>A SNP showed no significant effects on the native OCT1 promoter activity. Furthermore, the −1795G>A SNP was not associated with the pharmacokinetics of metformin, fenoterol, sumatriptan and proguanil in healthy individuals or tropisetron efficacy in patients undergoing chemotherapy. Allele-dependent differences in USF1/2 binding and nearly total loss in OCT1 promoter activity were detected for the G-allele of −201C>G, but the SNP is apparently very rare. In conclusion, common OCT1 promoter SNPs have only minor effects on OCT1 expression.
Statistical Analysis of Maximally Similar Sets in Ecological Research
Authors: Roberts David W.
Published: December 2018

Maximally similar sets (MSSs) are sets of elements that share a neighborhood in a high-dimensional space defined by a symmetric, reflexive similarity relation. Each element of the universe is employed as the kernel of a neighborhood of a given size (number of members), and elements are added to the neighborhood in order of similarity to the current members of the set until the desired neighborhood size is achieved. The set of neighborhoods is then reduced to the set of unique, maximally similar sets by eliminating all sets that are permutations of an existing set. Subsequently, the within-MSS variability of candidate explanatory variables associated with the elements is compared to random sets of the same size to estimate the probability of obtaining variability as low as was observed. Explanatory variables can be compared for effect size by the rank order of within-MSS variability and random set variability, correcting for statistical power as necessary. The analyses performed identify constraints, as opposed to determinants, in the triangular distribution of pair-wise element similarity. In the example given here, the variability in spring temperature, summer temperature, and the growing degree days of forest vegetation sample units shows the greatest constraint on forest composition of a large set of candidate environmental variables.
New Existence of Fixed Point Results in Generalized Pseudodistance Functions with Its Application to Differential Equations
Authors: Sanhan Sujitra , Sanhan Winate , Mongkolkeha Chirasak
Published: December 2018

The purpose of this article is to prove some existences of fixed point theorems for generalized F -contraction mapping in metric spaces by using the concept of generalized pseudodistance. In addition, we give some examples to illustrate our main results. As the application, the existence of the solution of the second order differential equation is given.
A Meta-Analysis on Randomised Controlled Clinical Trials Evaluating the Effect of the Dietary Supplement Chitosan on Weight Loss, Lipid Parameters and Blood Pressure
Authors: Moraru Cristina , Mincea Manuela Maria , Frandes Mirela , Timar Bogdan , Ostafe Vasile
Published: December 2018

Background and objectives: Erratic results have been published concerning the influence of the dietary supplement chitosan used as a complementary remedy to decrease the body weight of overweight and obese people. The published articles mention as secondary possible benefits of usage of chitosan the improvement of blood pressure and serum lipids status. We performed a meta-analysis evaluating body weight, body mass index, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure among overweight and obese patients. Materials and Methods: Searching MEDLINE, Cochrane up to December 2017 on clinical trials that have assessed the influence of chitosan used as a dietary supplement on overweight and obese patients. An additional study was identified in the References section of another meta-analysis. A total of 14 randomised control trials (RCT) were used to assess the effect on body weight, serum lipids and blood pressure. Results: The usage of chitosan as a dietary supplement up to 52 weeks seems to slightly reduce the body weight (−1.01 kg, 95% CI: −1.67 to −0.34). Considering the other parameters studied, the most significant improvement was observed in systolic and diastolic blood pressure: −2.68 mm Hg (95% CI: −4.19 to −1.18) and −2.14 mm Hg (95% CI: −4.14 to −0.14) in favour of chitosan versus a placebo. Conclusions: Based on the meta-analysis realized with 14 RCT we concluded that the usage of chitosan as a dietary supplement can lead to a slight short- and medium-term effect on weight loss and to the improvement of serum lipid profile and cardiovascular factors.
Nogier Reflex: Physiological and Experimental Results in Auricular Medicine–A New Hypothesis
Authors: Litscher Gerhard , Yannacopoulos Theodoros , Kreisl Peter
Published: December 2018

This editorial describes a new hypothesis concerning the nature and possible mechanisms of the Nogier reflex or reflex auriculo-cardiac (RAC; also vascular autonomic signal VAS). A multimodal concept for future RAC research is proposed.
Early Intervention is Important to Prevent Sensitization to New Allergens
Authors: Terada Tetsuya , Kawata Ryo
Published: December 2018

We review current management for allergic rhinitis and possible new treatments for this condition. Management of allergic rhinitis includes promotion of protective factors, avoidance of allergens, and possibly immunotherapy. In recent years, the incidence of allergic rhinitis has increased in many countries. Early intervention at different stages is an important part of management. Allergic disease in infants has been described as the allergic march, commencing with atopic dermatitis accompanied by infantile asthma and progressing to perennial allergic rhinitis induced by house dust mite allergy. In order to prevent polysensitization, allergen-specific immunotherapy should probably be initiated at an earlier age, especially in children with rhinitis who show monosensitization to house dust mite antigens.
Sustainable Hydrometallurgical Recovery of Valuable Elements from Spent Nickel–Metal Hydride HEV Batteries
Authors: Korkmaz Kivanc , Alemrajabi Mahmood , Rasmuson Åke C. , Forsberg Kerstin M.
Published: December 2018

In the present study, the recovery of valuable metals from a Panasonic Prismatic Module 6.5 Ah NiMH 7.2 V plastic casing hybrid electric vehicle (HEV) battery has been investigated, processing the anode and cathode electrodes separately. The study focuses on the recovery of the most valuable compounds, i.e., nickel, cobalt and rare earth elements (REE). Most of the REE (La, Ce, Nd, Pr and Y) were found in the anode active material (33% by mass), whereas only a small amount of Y was found in the cathode material. The electrodes were leached in sulfuric acid and in hydrochloric acid, respectively, under different conditions. The results indicated that the dissolution kinetics of nickel could be slow as a result of slow dissolution kinetics of nickel oxide. At leaching in sulfuric acid, light rare earths were found to reprecipitate increasingly with increasing temperature and sulfuric acid concentration. Following the leaching, the separation of REE from the sulfuric acid leach liquor by precipitation as NaREE (SO4)2·H2O and from the hydrochloric acid leach solution as REE2(C2O4)3·xH2O were investigated. By adding sodium ions, the REE could be precipitated as NaREE (SO4)2·H2O with little loss of Co and Ni. By using a stoichiometric oxalic acid excess of 300%, the REE could be precipitated as oxalates while avoiding nickel and cobalt co-precipitation. By using nanofiltration it was possible to recover hydrochloric acid after leaching the anode material.