bluuebunny/crossref_metadata_2025 huggingface dataset:
Medical Devices Using Nanotechnology to Treat Chronic Skin Lesions
Authors: Almutairi Meshal Nawaf Azeez , Almajed Mohammed Sulaiman , Alomran Abdulaziz Mohammed
Published: January 2025

When it comes to treating chronic skin lesions, nanotechnology has shown great promise. It provides novel ways to overcome the drawbacks of conventional therapy. Pressure sores and diabetic ulcers are examples of chronic skin disorders that present considerable challenges because of their persistence and resistance to traditional therapies. Precision drug delivery, increased tissue regeneration, and better wound healing are all made possible by nanotechnology through the use of nanoparticles, nanofibers, and nano-coatings. This review delves into the ways that nanotechnology is being used in medical devices intended for skin treatment, including improvements in antimicrobial dressings, medication delivery systems, wound healing materials, and skin graft upgrades. Furthermore, it emphasises how dynamic, on-demand wound care could be revolutionised by responsive nanomaterials and nanobots. Notwithstanding these developments, expanding production and negotiating complicated regulatory environments continue to provide difficulties. The successful application of nanotechnology in healthcare depends on guaranteeing the efficacy and safety of nanomaterials as well as resolving ethical issues with patient consent and long-term impacts. In order to address unmet medical requirements, future research and development must concentrate on regulating standards, discovering novel combinations of nanotechnology, and optimising the properties of nanomaterials. This analysis comes to the conclusion that although nanotechnology has enormous potential to revolutionise the treatment of chronic skin lesions, its complete adoption will necessitate overcoming ethical, legal, and technical obstacles in addition to ongoing cross-disciplinary collaboration and scientific innovation.
COMPARATIVE STUDY OF VEDIC AND CONVENTIONAL METHOD FOR ARITHMETIC OPERATION
Authors: Saxena Shilpi
Published: January 2025

The study compares the effectiveness of Vedic technique and traditional technique with special reference to speed math. The challenge to the research lies in increasing computational resources, especially in academic and competitions endeavours. A sample of 200 students was selected from two educational institutions in India which has both secondary school and an undergraduate college. There were two groups as one group strongly practiced Vedic techniques while the other group used normal techniques. An experimental pretest-posttest design was adopted in this study, and data gathered on computation time and error rate for the computation tests such as addition, subtraction multiplication and division were analyzed using the paired t-test and analysis of variance (ANOVA). Performance measurements of the present study indicate that, for all given conditions, the Vedic method can offer faster calculations and higher accuracy than conventional methods (p < 0.01); the improvement was observed to increase with cognitive complexity of the tasks. Statistical analysis of data showed that marginal and negative effects of the Vedic method remain stable across age and educational levels. The study shows that the learning of Vedic mathematics can enable individuals to become better computational thinkers, the case for teaching these methods in school is thereby justified.
Development of Desmos Application Design Integrated PBL Assisted Liveworksheet Based on Mathematical Literacy in AKM Preperation Efforts
Authors: Nuri Bulan , Isnani Wirdatul , Rizani Fitri
Published: January 2025

This research aims to develop a learning media using Desmos application integrated with PBL (Problem-Based Learning) assisted by live worksheets based on mathematical literacy in preparation for AKM (Minimum Competency Assessment); and determine the feasibility and practicality of the learning media using Desmos application integrated with PBL assisted by live worksheets based on mathematical literacy in preparation for AKM. The research method used is Research and Development with ADDIE models. The research instrument uses a rating scale for media experts, material experts, practitioners, and students. The results of the development of learning media on quadratic equations obtained a percentage of 95.45% with a very valid category from media experts. Material experts gave a percentage of 93.33% with a very valid category. Practitioners gave a percentage of 94.37% with a very practical category. The results of small group trials of students were declared fit for use, and the results of large group trials obtained a percentage of 39.29% strongly agreed and 57.14% agreed to be interested when using Desmos application media assisted by live worksheets. From the results of the research, the learning media developed is very valid and practical to be used in mathematics learning based on expert validation.
Management of Wilt Disease (Sclerotium rolfsii Sacc.) in Jasmine With Fungicides
Authors:   Department of Plant Pathology, Tamil Nadu Agricultural University, Coimbatore, P Muthulakshmi.
Published: January 2025

Sclerotial wilt of jasmine incited by Sclerotium rolfsii Sacc.is a serious
problem in jasmine growing districts of TamilNadu and caused complete
destruction the plant. .Uses of fungicides are one the most promising
management method in controlling the S. rolfsii infection. Hence the
present study was conducted with combination of fungicide molecules
to manage the disease. Among the tested fungicides, Tebuconazole 50%
+ Trifloxystrobin 25 % @ 1000ppm was found effective and recorded
maximum percent inhibition of 95.3 percent followed by Azoxystrobin
11% + Tebuconazole 18.3% at 1000ppm which recorded 94.11% as
compared to control under invitro conditions. The pooled mean field data
revealed that among the five treatments tested against wilt disease,
soil drenching with Tebuconazole 50% + Trifloxystrobin 25 % at 0.1%
at the time of planting + soil application on 30, 60, 90 and 120 days
after planting was effective in reducing the wilt incidence to 14.0% with
the highest yield of 1312 g/ plant with an estimated yield of 8.4 t/ha
with maximum CB ratio of 3.63 as compared to untreated control which
recorded 32 %,525 g/ plant , 3.36 t/ha and CB ratio of 1.48 respectively.
Assessing the Impact of Farm Size on Cocoon Production Efficiency and Profitability in Non-Traditional Districts of Tamil Nadu
Authors:   Directorate of Open and Distance Learning,TNAU,Coimbatore, S Susikaran , B Karthick mani Bharathi ,   Department of sericulture,FC&RI,TNAU ,Coimbatore, c Kiruthika ,   Department of sericulture ,FC&RI,TNAU,Coimbatore, S Vijay ,   National Silkworm Seed Organization, Central Silk Board, Dakshin Bhawanipur, West Bengal, P Balasubramaniam ,   National Silkworm Seed Organization, Central Silk Board, Dakshin Bhawanipur, West Bengal
Published: January 2025

The current study aimed to determine the costs and returns associated
with producing cocoons for different farmer groups in Tamil Nadu’s non
traditional districts, including Coimbatore, Tiruppur, Erode, Dindigul and
Theni in the Western Zone. The study’s sample size consisted of 45
farmers who owned marginal, small and medium-sized plots of land. These
farmers were chosen at random for the study. According to the findings,
Received: 19 Jul 2024
Revised: 27 Jul 2024
Accepted: 16 Aug 2024
marginal farmers had to spend Rs. 2, 21,531.20/- for the production of
cocoons, whereas they would receive Rs. 7, 27,460.80/- in return for
the cocoon waste and raw cocoons. On the other hand, it was discovered
that small farmers had to spend Rs. 3, 41,794.89/- for the production
of cocoons, while they received returns of Rs. 14, 16,072.40/- from the
cocoon and waste. Comparably, the cost of producing cocoons for medium
sized farms was determined to be Rs. 4, 93,193.60/-, while the returns
from the cocoon and waste came to Rs. 21, 19,064.96/-. As a result, it
can be concluded that medium farmers have a greater benefit-cost ratio—
roughly 1:4.3. Therefore, medium farmers faced the highest costs and
returns from cocoon production, followed by small and marginal farmers.
Millet’s cultivation in India: Challenges and Opportunities towards achieving sustainable farming and inclusive development
Authors:   Department of Agriculture Extention, HRS,TNAU,PECHIPARAI, t Raj Pravin
Published: January 2025

Millets are cultivated in resource poor areas of our nation by small
and marginal farmers. Being climate resilient, improving their production
and productivity through the use of improved high-yielding varieties is
the source to address many of the malnourishment issues faced by our
women, children, and low-income groups. The establishment of Millets
Park, the creation of a new millet movement empowering primitive,
vulnerable tribal groups, and ensuring gender diversity are challenges
and opportunities to be explored towards achieving sustainable farming
and inclusive development.
EDITANDO GENES:
Authors: Nagel Jordana Caroline
Published: January 2025

O livro "Editando Genes: O Papel do CRISPR no Melhoramento Genético Animal" explora o impacto revolucionário da biotecnologia na produção animal. A obra aborda desde os fundamentos e princípios tradicionais do melhoramento genético até a aplicação do CRISPR-Cas9, uma ferramenta precisa e inovadora que permite modificar características genéticas para promover saúde, produtividade e sustentabilidade. Por meio de estudos de caso e análises detalhadas, são discutidas as possibilidades práticas, os avanços tecnológicos e os desafios éticos, legais e sociais da edição genética. Um convite para compreender como a ciência está transformando o futuro da agropecuária e da biotecnologia.
GENÉTICA E PRODUÇÃO ANIMAL:
Authors: Nagel Jordana Caroline
Published: January 2025

Este guia aborda os fundamentos, avanços e aplicações práticas do melhoramento genético em animais de produção. Com uma abordagem abrangente, explora desde os conceitos básicos de genética até a implementação de tecnologias modernas, como CRISPR e seleção genômica, para otimizar características produtivas e reprodutivas. A obra detalha métodos de avaliação genética, seleção e biotecnologias aplicadas, destacando seus impactos na eficiência alimentar, sustentabilidade e adaptação às demandas globais. Ao mesmo tempo, discute considerações éticas e a preservação da diversidade genética, oferecendo uma visão equilibrada e inovadora para produtores, estudantes e pesquisadores da área.
CARACTERIZAÇÃO ANATÔMICA E FUNCIONAL DA DOENÇA CORONÁRIA OBSTRUTIVA E ESCORES DE RISCO PARA A TOMADA DE DECISÃO TERAPÊUTICA
Authors:   Instituto Prevent Senior. São Paulo, SP, Brasil, Jacob Martins Izabela , Esper Rodrigo ,   Instituto Prevent Senior. São Paulo, SP, Brasil, Labunie Andre ,   Instituto Dante Pazzanese de Cardiologia. São Paulo, SP, Brasil., Ribeiro Expedito ,   Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo (Incor FMUSP). São Paulo, SP, Brasil,   Hospital Sírio Libanês. São Paulo, SP, Brasil,   Hospital Samaritano Paulista. São Paulo, SP, Brasil,   Hospital Oswaldo Cruz. São Paulo, SP, Brasil
Published: January 2025

A doença arterial coronariana (DAC) permanece como uma das principais causas de mortalidade no mundo e o exame padrão-ouro para o seu diagnóstico é a angiografia coronariana invasiva. A quantificação do percentual de obstrução pode ser realizada por estimativa visual ou por angiografia coronária quantitativa (quantitative coronary angiography — QCA). A cardiologia intervencionista tem experimentado avanço nos últimos anos, permitindo uma análise da doença coronariana não apenas anatômica, mas também funcional. O uso de dispositivos para avaliação anatômica, como a ultrassonografia intracoronária (USIC) e tomografia por coerência óptica (optical coherence tomography — OCT) e, em conjunto, a avaliação funcional da DAC com a reserva fracionada de fluxo (fractional flow reserve — FFR) e reserva de fluxo fracionada instantâneo (instantaneous wave-free ratio — iFR) modificaram o cenário do tratamento da DAC, por tornar possível maior compreensão da fisiopatologia, dimensão e isquemia relacionada à lesão, contribuindo de maneira significante para a acurácia diagnóstica e terapêutica do método. A angiotomografia coronária se consolida também como ferramenta importante no diagnóstico e estratificação não invasiva de DAC, já com possibilidade de avaliação anatômica e funcional descrita em estudos recentes. Ao longo dos anos, diversos escores e classificações foram criados para predição de risco e auxílio na tomada da decisão terapêutica de pacientes com DAC. Os escores utilizam critérios anatômicos (como classificação de Gensinni, ACC/AHA modificada por Ellis, Leaman e SYNTAX escore I), anatômicos associados a variáveis clínicas (Global Risk Stratification e SYNTAX escore II) e critério funcional (SYNTAX funcional — FFS). As classificações e escores criados ao longo do tempo são ferramentas importantes para o processo de tomada de decisão colegiada em Heart Team
CRITÉRIOS PARA INDICAÇÃO E RESULTADOS CLÍNICOS TARDIOS DA INTERVENÇÃO CORONÁRIA PERCUTÂNEA NA DOENÇA CORONÁRIA CRÔNICA
Authors:   Hospital do Coração da Associação do Sanatório Sírio. São Paulo SP, Brasil, Rodrigues Alves Claudia Maria , Wolff Gowdak Luís Henrique ,   Instituto do Coração da Faculdade de Medicina/USP. São Paulo SP, Brasil, Tanajura Luiz Fernando ,   Instituto Dante Pazanesse de Cardiologia. São Paulo SP, Brasil, Ximenes Meireles George ,   Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo. São Paulo SP, Brasil, Pereira Marques Gomes Manuel ,   Hospital do Coração da Associação do Sanatório Sírio. São Paulo SP, Brasil,   Hospital Nipo-Brasileiro. São Paulo SP, Brasil, Marin-Neto José Antônio ,   Faculdade de Medicina de Ribeirão Preto – USP, Ribeirão Preto, SP, Brasil
Published: January 2025

Nesta revisão, os autores apresentam os resultados dos mais recentes estudos comparando tratamento médico otimizado com intervenção coronária percutânea a ele adicionada na doença coronária estável. O conjunto de resultados permite concluir que a intervenção assim executada é superior para mais rápida e frequente redução de sintomas, inclusive em estudos controlados com grupo placebo, sem elevar o risco de relevantes complicações imediatas e tardias. Da mesma forma, somam-se evidências de metanálises mostrando a eficiência na redução de infarto espontâneo, especialmente para pacientes com maior número de vasos com obstrução severa e com disfunção ventricular. O resultado de mortalidade total é semelhante entre as duas estratégias nesta população de relativo baixo risco, porém redução de mortalidade cardiovascular já é apontada em metanálises. Ao final, salienta-se a importância da realização de procedimentos executados com a melhor tecnologia de imagem e fisiologia para obtenção dos melhores resultados tardios, bem como manutenção de seguimento farmacológico rigoroso a longo prazo
Nanoparticles based drug delivery system for cancer therapy
Authors: Nisha D. Masane  , Arti S. Rathod  , Vaibhav G. Akhand  , Vinayak A. Katekar  , Swati P. Deshmukh
Published: January 2025

Nanoparticle-based drug delivery systems (NDDS) have emerged as a transformative approach in cancer therapy, offering significant advantages over conventional treatments. This review explores the diverse applications of nanoparticles in cancer therapy, highlighting their role in enhancing drug delivery, reducing systemic toxicity, and overcoming challenges such as drug resistance and tumor heterogeneity. Nanoparticles, including liposomes, polymeric nanoparticles, metallic nanoparticles, and more recently developed systems like carbon nanotubes, dendrimers, and exosomes, are engineered for targeted drug delivery. These nanoparticles improve the pharmacokinetics and bioavailability of anticancer agents, enabling site-specific accumulation through mechanisms such as the enhanced permeability and retention (EPR) effect and active targeting via ligands. Additionally, nanoparticles play a critical role in combination therapies, immunotherapy, and overcoming multidrug resistance (MDR) by bypassing efflux pumps and targeting cancer stem cells (CSCs).
Emerging innovations in “smart” nanoparticles, capable of responding to environmental triggers like pH or temperature, as well as their integration with RNA-based therapies and artificial intelligence (AI) for personalized treatment, represent the future direction of cancer nanomedicine. Despite the progress, regulatory challenges, safety concerns, and large-scale manufacturing remain key hurdles. This review provides an overview of the current landscape, challenges, and future prospects of NDDS in cancer therapy, emphasizing their potential to improve clinical outcomes and revolutionize cancer treatment.
Glycine betaine seed priming to induce salt stress tolerance in durum wheat (Triticum durum Desf.)
Authors: Afef Othmani  , Rim Hajri  , Mouna Mechri  , Hayet Beltayef  , Sabrine Touihri
Published: January 2025

Salinity stress is an important environmental factor that limits plant growth and productivity in the world. The effect of seed priming with glycine betaine (GB) on the germination of four durum wheat varieties (Salim, Maâli, Monastir and Carioca) under salt stress conditions induced by sodium chloride (NaCl) were investigated. Three concentrations of GB (0, 50 and 100 mM) were tested under three levels of salt stress (0, 100 and 200 mM). The main results obtained showed significant effects of treatments and varieties on most studied traits. Salt stress had a negative effect on the germination and growth of wheat seedlings. However, seed priming with GB significantly improved seed germination under both no stress and salt stress conditions. Under severe salt stress conditions (200 mM NaCl), the highest values of germination percentage (65.5%), mean daily germination (0.825), vigor index (119.566), shoot length (0.568 cm) and root length (3.05 cm) were obtained using 50 mM GB. Consequently, the results of this study indicate that GB seed priming at 50 mM can to help durum wheat grow in salt-stress conditions.
Assessment of patient satisfaction in quality of healthcare services rendered in hemodialysis department unit in Manuel v. Santiago medical center hospital in Trece Martires Cavite
Authors: Lino Lee Ortiga Siason
Published: January 2025

This research explores the satisfaction levels of patients receiving hemodialysis services at the Manuel V. Santiago Medical Center Hospital in Trece Martires, Cavite. As renal diseases become increasingly common, understanding patient experiences can help improve service delivery in healthcare settings. This is a cross-sectional study that employs a qualitative approach to gathering feedback from patients and healthcare professionals to delineate areas for improvement and highlight successful practices. The implications of these findings for policy and future healthcare reforms will be discussed and intends to contribute to enhancing the overall patient experience in the facility.
Verification of analytical performance of Creatine Kinase isoenzyme MB (CK-MB) on the Alinity c® Experience from the Biochemistry Laboratory of Mohammed VI University Hospital in Oujda
Authors: Sara Moulay Rchid  , Mohamed Karim El Azzouzi  , Kholoud Krimi  , Dounia El Moujtahide  , El houcine Sebbar  , Mohammed Choukri
Published: January 2025

The verification of analytical methods is a requirement of the NF EN ISO 15189 standard. It involves evaluating the performance of an analytical method according to a well-defined protocol and comparing it to pre-established analytical objectives. In this study, we present the results of the verification protocol for the measurement method of creatine kinase isoenzyme MB (CK-MB) on the Alinity c® analyzer, which is employed for functional exploration of the heart.
Our study is conducted according to the criteria of Scope A detailed in the Verification/Validation Guide for Methods in Medical Biology, following the SH GTA 04 recommendations from COFRAC. The verification focused on the CK-MB assay on the Alinity c® analyzer using International Federation of Clinical Chemistry (IFCC) method based on immunoinhibition principle for an assessment of analytical performance in terms of repeatability and intermediate precision. these results were aligned with the manufacturer's specifications.
The results obtained for various CK-MB assay verification criteria on the Alinity c® analyzer demonstrate satisfactory repeatability across one level with CV = 1.29%. Intra-laboratory reproducibility was satisfactory for one level with CV = 2.58%. The coefficient of variation (CV) values obtained in our study were compared with manufacturer's specifications, no CV reference values were established by French Society of Clinical Biology SFBC.
The findings from this study have allowed us to verify the performance of the CK-MB assay method and to compare them with the objectives set in the accreditation process to which our laboratory is committed.
Navigating ethical dilemmas in Generative AI Development: A framework for responsible innovation
Authors: Hari Kiran Vuyyuru
Published: January 2025

This comprehensive article explores the evolving landscape of ethical challenges and solutions in generative AI development, focusing on key areas, including data privacy, algorithmic bias, and implementation frameworks. Through detailed analysis of case studies and research findings, the study examines successful approaches to ethical AI implementation across various sectors, particularly in content generation and code development. The article presents a structured framework for ethical decision-making, emphasizing the importance of proactive assessment, stakeholder engagement, and continuous monitoring. By investigating cultural integration strategies and technical safeguards, this study provides valuable insights into establishing and maintaining ethical AI systems while balancing innovation with responsible development practices in an increasingly complex technological landscape.
Utilization of wearable technology data in chronic disease management
Authors: Oluwabusayo Oni  , Topeola Balkis Awofala
Published: January 2025

Chronic diseases such as diabetes and cardiovascular disease pose significant challenges for patients and healthcare systems around the globe. The advent of wearable technology, capable of monitoring vital health metrics such as glucose levels and heart rate in real-time, presents transformative possibilities for managing these conditions. This paper thoroughly explores the effectiveness of wearable devices in enhancing patient outcomes, emphasizing the role of continuous monitoring and timely interventions that these technologies facilitate. Additionally, it examines the critical aspects of patient compliance and engagement, highlighting how the design and functionality of wearable devices influence long-term use and adherence. The discussion extends to the integration challenges of these devices within existing healthcare frameworks, focusing on data privacy, accuracy, and the need for robust data management systems. The paper also considers the broader implications of wearable technology, suggesting that beyond individual patient management, these devices hold potential for large-scale health data analysis and policy-making, ultimately guiding future research directions to maximize their benefits in chronic disease management. This comprehensive examination not only underscores the capabilities of wearable technology but also maps out the necessary advancements and policy adjustments required to fully integrate these innovative tools into mainstream healthcare practices.
Health seeking behavior among adult patients with cataract attending eye clinic at Homa bay County Teaching and Referral Hospital
Authors: CYNTHIA ANYANGO OLOO
Published: January 2025

Cataract; is the clouding of the natural crystalline lens of the eye leading to preventable blindness. Globally, cataracts resulted in approximately 15.2 million cases of blindness in the population over the age of 50 years in 2020. Majority of patients with cataract seek treatment late when vision loss has deteriorated and some even have total blindness. Cataract is a highly treatable condition when detected early and results in good visual outcomes. The main objective of the study was being to determine the health seeking behavior among adult patients with cataract attending eye clinic at Homa Bay County referral hospital so as to reverse the trend of blindness. A descriptive cross-sectional study design was used. The study population were all patients attending the eye clinic during the period of data collecting and are estimated to be 85 patients. The census method of sampling was applied so as to include the whole population in the study. Some data were collected from the patient records while others were through personal interviews. Data were analyzed using SPSS version 27, and descriptive variables such as means and frequencies were calculated. The findings were presented in the form of graphs and tables. There were total of 59 respondents who participated on the study. Majority of the respondents 34 (59.3%) were aged between 68 years and above ,37 (62.7%)were females and 22 (37.3%) were males.40 (66.1%) presented to the clinic with VA of > 3/60. 36 (61.0%) reached primary level, only 1(1.7%) reached tertiary level, 31(52.54) have sought treatment at the chemist before reporting to the hospital. 42 (71.2%) reported from 6 months and above to the facility, 57 (96.6%) comes from Homa Bay. In the study we noticed that 52.5%( 31 out of 59) had sought treatment first from the chemist. In this study, 61.0% (36 out of 39) respondents had poor access to eye care service due to cost of transport, 62.7% (37 et of 59) participants was due to cost of treatment and 69.5% (41 out of 59) was due to distance. In this study 35.6% (21 out of 59) respondents had blood pressure and cataract 18 out of 21 had poor vision of >6/60. 35 respondents had no blood pressure and 32 had severe visual acuity to blindness and 27.3% had no blood pressure. Pressure and diabetes as a comorbidity, It was concluded that majority of participants seek treatment at the chemist, decreased eye sight was a sign of cataract, reached primary level, believed that decreased eye sight was a sign of cataract It was also observed that patient who had cataract majority had no high blood pressure. It was recommended that decentralization of eye screening and treatment at the sub-county levels where is easily accessible. Harmonizing on the cost of treatment and also invite donors to fund on free camp to help the vulnerable. Deployment and training of eye workers and setting of full equipped 8 sub-county eye unit center for easy accessibility.
Enhancing machine learning models: addressing challenges and future directions
Authors: Sateesh Kumar Rongali
Published: January 2025

Machine learning is considered as a core of modern artificial intelligence with progressive advancements throughout a spectrum including but not limited to healthcare and finance, natural language processing and self-driving cars. However, several problems remain to affect the efficiency, equal opportunities of users, and adaptability of ML models for an even faster-growing era. The limitations include shortage of high quality and access to training data, model complexity that can lead to overfitting, built in bias of the algorithm, interpretability and finally, the computational density needed for such big data models. These problems posed challenges to translate the knowledge derived from the ML systems into real-world use as well as hindering generalization of ML systems, particularly the medical and legal fields that have requirements of fairness and interpretability. These are the basic issues this journal addresses and provides possible ways of enhancing the performance of the ML models. To mitigate the problem of data deficiency, we present various techniques including data augmentation and transfer learning. To mitigate this issue, we present regularization strategies and methods of model validation. Several prevention methods are also mentioned including biasing of Algorithm and models using adversarial biasing, and Fairness-aware learning methods. Furthermore, we explore the increasing relevance of post-hoc model interpretability such as the SHAP and LIME methods which explain model’s outputs in a more detailed manner. The objective of the present Journal is to support further development of more stable, efficient and fair Machine Learning systems. In this paper, recent developments and long-term solutions are discussed to prepare the way for better and more responsible use of AI in the future.
Diversity and dynamics of insect pests of paddy rice stored in the city of Issia; Central-West of Côte D’Ivoire
Authors: FONDIO Drissa  , SIB Ollo  , SORO Lacina  , DAO Hassane  , YAO N’guessan  , DIABATE Seydou
Published: January 2025

Paddy rice stocks are attacked by pests that sometimes cause enormous damage. This study aims to assess the diversity and abundance of insect pests of stored paddy rice in the city of Issia. Three samples in three kilograms were taken per bag at different levels of the bag and sorted manually in three stores in the city. The collected insects were examined using a Binocular magnifying glass in the laboratory. Overall, 4867 insects were inventoried. They are all beetles belonging to three families; Bostrichydae (Rhyzoperta dominica); Tenebrionidae (Tribolium chestnut); Curculiondae (Sitophilus oryzae L and Sitophilus zeamais). Data analysis showed that Tenebrionidae slightly predominate with 36.78%; followed by Bostrichydae with 35.63% and finally Curculiondae with 27.59. The study revealed that environmental conditions and storage duration influence the multiplication and evolution of insect populations in stocks.
The effectiveness of antifibrinolytic drugs as anti-Haemorrhage treatment for patients with anticoagulant during tooth extraction procedure: A review
Authors: Tasya Horax  , Tsaniya Kamilah  , Indeswati Diyatri
Published: January 2025

Significant increases in major bleeding have been reported in patients receiving antithrombotic therapy who are undergoing dental extractions. To manage this risk, local hemostatic agents are commonly used, either to enhance the blood's natural clotting process or to mechanically limit external bleeding. These agents work by reducing the proteolytic activity of plasminogen activators, which prevents the formation of plasmin and inhibits clot dissolution. Among the various local hemostatic agents available, such as gelatin sponge, collagen sponge, oxidized cellulose, fibrin sealant, and tannic acid, tranexamic acid (TA) is the most frequently utilized. TA is widely employed both topically and as a mouthwash due to its proven efficacy in controlling bleeding. It can be administered in various forms, including as a dressing with gauze, local irrigation (250 mg/5mL solution), or as an oral suspension using crushed tablets (250 mg) mixed with saline or local anesthetic. Furthermore, it can be applied directly to the wound site for localized effect. The most common and effective approach involves using TA as a mouthwash before the extraction and continuing its application for 3-7 days post-extraction to minimize bleeding risk and promote hemostasis. The findings suggest that the localized application of antifibrinolytic agents can play a crucial role in ensuring safe dental extractions for anticoagulated patients.
Breastfeeding impact on kidney health : updated evidence
Authors:   1LIRSSEI Research Laboratory, Faculty of Medicine, University of Setif-1, Algeria. 2Department of Pediatrics, University Hospital of Setif, Algeria, RAHMOUNE Hakim , BOUTRID Nada , BOUTRID Hala ,   Department of Pediatrics, EHS El Eulma, Algeria.,   3Department of PDepartment of Obstetrics-Gynecology, M.L. Debaghine University Hospital of Bab-El-Oued, Algiers, Algeria
Published: January 2025

Breastfeeding is extensively acknowledged for its numerous health benefits, particularly during the critical early stages of life. This article synthesizes contemporary evidence regarding the influence of breastfeeding on renal function and health, drawing from a diverse array of international studies. The findings consistently demonstrate that breastfeeding is associated with enhanced renal growth, improved kidney function, and a diminished risk of various renal pathologies. Specifically, breastfed infants exhibit significantly larger renal volumes and elevated glomerular filtration rates, compared to their formula-fed counterparts. Moreover, exclusive breastfeeding correlates with lower incidences of urinary tract infections and nephrotic syndrome. This review reaffirms the critical importance of breastfeeding for both immediate infant health, and its potential to shape renal health throughout life, thereby, supporting the Developmental Origins of Health and Disease (DOHaD) hypothesis, and emphasizing the necessity for ongoing advocacy in this domain.
Guerras culturais e música pop
Authors: Zincone Rafael
Published: January 2025

Este artigo aborda a cultura pop como força mobilizadora de debates de ordem política no momento de ascensão da extrema-direita no Brasil. Assim, o objetivo é investigar de que modo esses discursos difamatórios mobilizaram, de um lado, valores sociais reacionários e, de outro, como cantoras pop constituíram vetores de reflexão na esfera política a partir de seus posicionamentos nas redes sociais digitais. Na empiria, apresenta pesquisa online de caráter qualitativa envolvendo controvérsias em redes sociais digitais referentes às artistas supracitadas e ao agravamento da polarização política nos últimos anos.
Analysis Of Farming And Agroindustry Of Hanjeli (Coix Lacryma Jobi L.)
Authors: Hidayah Mutiara , Masithoh Siti , Novita Ita
Published: January 2025

This study aims to determine the characteristics of hanjeli farmers in Waluran Mandiri Village, Waluran Subdistrict, to determine the feasibility of hanjeli farming in Waluran Mandiri Village, Waluran Subdistrict, and to determine the agroindustry of processed hanjeli in Hanjeli Tourism Village, Waluran Mandiri Village, Waluran Subdistrict. The analysis method used in this research is Descriptive Analysis and Quantitative Analysis. Agro-industry made from hanjeli plants is part of the production of the Hanjeli Tourism Village in Waluran Mandiri Village, Waluaran District, which is managed by KWT Mekar Mandiri. The main ingredients for processed agro-industry use all types of hanjeli plants. The products produced from this hanjeli plant can be consumed and cannot be consumed. The types that can be consumed are glutinous hanjeli and hanjeli batok, which are usually processed into foods such as rengginang, sponge cake, supplements, porridge and several other types. For stone type hanjeli plants, they are usually used as accessories such as necklaces, prayer beads bracelets, and key chains. The results obtained from research with an average land area of 0.521 ha resulted in hanjeli farming income of Rp.768,037 with receipts of Rp.3,408,000 and resulted in total costs of Rp. 2,639,963 during one planting production cycle (6 months). The amount of R / C on hanjeli crop farming is 1.29.
FACTORS AFFECTING THE WORK MOTIVATION OF PLANTATION OVERSEERS AT FAP AGRI LIMITED LIABILITY COMPANY
Authors: Sunny Khalid , Jumiati Elly , Wahyuni Etty
Published: January 2025

This article shows identification about the intrinsic and extrinsic factors that influence the work motivation of supervisors (plant foremen and plant clerks) at PT. FAP AGRI, North Kalimantan. The decline in supervisor motivation at the company has caused issues such as unkempt and undisciplined appearances, as well as an increased resignation rate. This study aims to provide a basis for consideration for the company in making policies to improve the performance of supervisors at PT. FAP AGRI. Data was collected using a census method on 109 supervisors who are training center (TC) graduates and still employed at PT. FAP AGRI. Data collection was conducted using a Likert scale questionnaire and analyzed using Structural Equation Modelling – Partial Least Square (SEM–PLS). The results of the study indicate that the intrinsic factors significantly influencing work motivation include self-perception, self-esteem, personal expectations, and personal needs. The extrinsic factors that influence include the type and nature of the work, work groups, work environment, and salary. The analysis shows that extrinsic factors have a greater influence compared to intrinsic factors on supervisor work motivation. This study provides recommendations for PT. FAP AGRI to focus on enhancing extrinsic factors to improve the work motivation and performance of supervisors
The Effect of Counseling Based on Functional Analytic Psychotherapy with Enhanced Cognitive Therapy on Married Adolescent Women’s Sexual Self-efficacy: A Prospective Study
Authors: Gholami Maryam , Alidousti Katayoun , Taebi Mozhgan , Jahani Yunes , Ahmadi Atefeh
Published: January 2025

Background: Sexual well-being is a vital aspect of the overall quality of life. Sexual self-efficacy is a key factor in improving of women’s sexual well-being. This study aimed to determine the effect of counseling based on functional analytic psychotherapy (FAP)-enhanced cognitive therapy (CT) on sexual self-efficacy in married adolescent women. Methods: This prospective clinical trial, conducted in 2019, used a pre-test/post-test design with a control group. The study included 80 urban and rural married adolescents who met the inclusion criteria and were referred to the health centers in Darab and surrounding villages. Out of 350 participants, 150 adolescents were included in the study and were allocated to two groups. The counseling program for the intervention group was carried out by the researcher over 16 sessions, held twice a week for 90 minutes each. In contrast, the control group received routine education. The intervention group received counselling based on FAP-enhanced CT, while the control group did not receive this training during the study. The data collected from the questionnaires were imported into SPSS 24, and analyses were performed using analysis of covariance (ANCOVA), paired t-test, and independent t-test. Results: There was no significant difference in sexual self-efficacy between the two groups at pre-test time (p > 0.05); however, a significant difference was observed at post-test (p < 0.0001). Additionally, there was a significant difference between the mean scores of sexual self-efficacy before and after the intervention in the intervention group (p < 0.0001), while no significant difference was observed in the control group (p = 0.25). Conclusion: The results suggest that counselling based on FAP-enhanced CT provided to married adolescent women significantly improves their sexual self-efficacy. Clinical Trial Registration: The trial protocol was registered with the Iranian Registry of Clinical Trials on 16/06/2019, IRCT20190217042736N1 (https://www.irct.ir/trial/37718).
Diagnosis of Malignant Endometrial Lesions from Ultrasound Radiomics Features and Clinical Variables Using Machine Learning Methods
Authors: Li Shanshan , Wang Jiali , Zhou Li , Wang Hui , Wang Xiangyu , Hu Jian , Ai Qingxiu
Published: January 2025

Background: The prognosis of patients with early diagnosis of malignant endometrial lesions is good. We aimed to identify benign and malignant lesions in endometrial tissue, explore effective methods for assisting diagnosis, and improve the accuracy and precision of identifying endometrial lesions. Methods: 1142 ultrasound radiomics and 18 clinical features from 1254 patients were analyzed, from which 36 features were selected for machine learning. We sketched the region of interest (ROI) of the abnormalities on the ultrasound images. Then, the radiomics features were extracted. Six common machine learning algorithms, including Support Vector Machine (SVM), Logistic Regression, Decision Tree, Random Forest, Gradient Boosting Tree, and k-Nearest Neighbors, were employed to identify benign and malignant changes in endometrial tissue. Cross-validation and grid search techniques for hyperparameter tuning were utilized to obtain the best model performance. Accuracy, precision, sensitivity, F1-scores, area under the curve (AUC), cross-validation average score and bootstrap average accuracy were also used to evaluate algorithm performance, classification accuracy, and generalization capability. Results: We combined 21 ultrasound characteristics and 15 clinical characteristics to develop and validate six common machine learning algorithms. After internal validation, the best models were the Random Forest models, with accuracy of 89%, precision of 93%, sensitivity of 97%, F1-score of 95%, and AUC of 95%, as well as a 10-fold cross-validation average score of 95% and bootstrap average accuracy of 94%, implying flawless classification in the test set. Conclusions: We identified the clinical and ultrasound features in the early diagnosis of benign or malignant lesions in endometrial tissue. And Random Forest model algorithms have demonstrated excellent performance in identifying benign and malignant changes in endometrial tissue. This is significant for enhancing early diagnostic accuracy and improving treatment outcomes and long-term management.
Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial
Authors: Shan Haiyan , Xu Mingyuan , Ni Jie , Zhou Ling , Xue Mengchun , Xue Jun , Yuan Xiaohuan , Tao Luyang , Zhang Mingyang , Zhang Hong
Published: January 2025

Background: Severe endometrial injury constitutes a significant risk to female fertility, often leading to the development of intrauterine adhesions. Pyroptosis, a form of programmed cell death associated with inflammation, is initiated by the cleavage of gasdermin family proteins by caspase, which has been implicated in endometrial injury. In recent years, hydrogen sulfide (H2S), a gaseous signaling molecule, exerts significant regulatory effects on pyroptosis in diverse pathological processes. The aim of this study is to elucidate the role of H2S in facilitating functional recovery of the endometrium following injury in a murine model. Methods: A prospective laboratory based randomized control trial was performed to evaluate the protective role of H2S in endometrial injury. Ethanol-induced endometrial injury mouse models were established and H2S donor sodium hydrosulfide (NaHS) was randomly administered to the injured mice. Western blot analysis was conducted to assess changes in the expression of endogenous H2S metabolism and pyroptosis-related markers and histological analysis (Hematoxylin & Eosin and Masson staining) was employed to examine alterations in endometrial morphology. Finally, a fertility test was performed to evaluate the restoration of the uterine function. Results: Following endometrial injury, the expression of key endogenous H2S enzymes-cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST)-is significantly reduced, while the levels of pyroptosis-related proteins are elevated (p < 0.05). However, treatment with H2S resulted in an increase in the expression of endogenous H2S enzymes and a decrease in pyroptosis-associated proteins compared to the Model group (p < 0.05). Moreover, endometrial morphology and embryo count showed the most pronounced improvement in the H2S treatment group (p < 0.05). Conclusions: This study confirms the therapeutic efficacy of H2S in facilitating the recovery of injured endometrium and revealed its potential therapeutic mechanism, offering a promising therapeutic avenue for patients with severe endometrial injury.
The Application of Three-dimensional Shear Wave Elastography in the Detection of Inguinal Lymph Node Metastasis in Gynecological Malignancies
Authors: Shen Yuping , Dai Jiulong , Li Jiami , Lu Man
Published: January 2025

Background: Accurate assessment of lymph node involvement is essential for prognosis and guiding treatment decisions in gynecological cancers, as it directly influences therapeutic strategies and patient outcomes. However, conventional imaging techniques, such as ultrasound and computed tomography (CT), demonstrate limited accuracy in determining the nature of lymph nodes. This study implements three-dimensional shear wave elastography (3D-SWE), an innovative technique that quantifies the stiffness of inguinal lymph nodes (ILN) in patients with gynecological cancers. This approach offers a more comprehensive assessment of ultrasound elastography compared to traditional methods. Methods: This retrospective study evaluated 120 ILNs from patients with gynecological cancers who underwent conventional ultrasound (US), two-dimensional shear wave elastography (2D-SWE), and multiplanar 3D-SWE. The diagnostic performance was analyzed using receiver operating characteristic (ROC) methodology, enabling a comprehensive comparison of the sensitivity and specificity of 3D-SWE relative to conventional ultrasound and 2D-SWE. Pathology results from lymph node resections or biopsies served as the reference standard. Results: Final pathology confirmed 65 metastatic and 55 benign lymph nodes. The maximum (Emax) and average (Emean) elasticity values from 2D-SWE and 3D-SWE for malignant lymph nodes were significantly higher than those for benign lymph nodes (p < 0.0001). ROC analysis indicated that for identifying metastatic lymph nodes, the area under the curve (AUC) values were 0.798 for 2D-SWE Emax, and 0.828, 0.839, and 0.816 for the transverse, sagittal, and coronal planes of 3D-SWE Emax, respectively. The differences between these AUC values were not statistically significant (p > 0.05). Furthermore, Emax values consistently surpassed Emean values in terms of characterization accuracy across modalities. Although no significant differences were observed between 2D-SWE and 3D-SWE, the sagittal view Emax yielded the best AUC, indicating optimal diagnostic precision overall. Conclusions: 3D-SWE, particularly using the sagittal Emax parameter, effectively distinguishes benign lymph nodes from metastatic ones by quantitatively evaluating the stiffness of ILNs in relation to gynecological tumors. Serving as a dependable diagnostic method for lymph nodes, 3D-SWE may help reduce the necessity for invasive biopsy procedures in some cases.
Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation
Authors: Vo Ha Vy Thi , Kim Namdoo , Lee Hyuck Jin
Published: January 2025

In recent years, the role of coenzymes, particularly those from the vitamin B group in modulating the activity of metalloenzymes has garnered significant attention in cancer treatment strategies. Metalloenzymes play pivotal roles in various cellular processes, including DNA repair, cell signaling, and metabolism, making them promising targets for cancer therapy. This review explores the complex interplay between coenzymes, specifically vitamin Bs, and metalloenzymes in cancer pathogenesis and treatment. Vitamins are an indispensable part of daily life, essential for optimal health and well-being. Beyond their recognized roles as essential nutrients, vitamins have increasingly garnered attention for their multifaceted functions within the machinery of cellular processes. In particular, vitamin Bs have emerged as a pivotal regulator within this intricate network, exerting profound effects on the functionality of metalloenzymes. Their ability to modulate metalloenzymes involved in crucial cellular pathways implicated in cancer progression presents a compelling avenue for therapeutic intervention. Key findings indicate that vitamin Bs can influence the activity and expression of metalloenzymes, thereby affecting processes such as DNA repair and cell signaling, which are critical in cancer development and progression. Understanding the mechanisms by which these coenzymes regulate metalloenzymes holds great promise for developing novel anticancer strategies. This review summarizes current knowledge on the interactions between vitamin Bs and metalloenzymes, highlighting their potential as anticancer agents and paving the way for innovative, cell-targeted cancer treatments.