bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of a Model Estimating the Budget Impact of Video Capsule Endoscopy for Surveillance of Crohn’s Disease in an Italian Center
Authors: Saunders Rhodri , Calabrese Carlo , Gelli Dania , Davis Jason , Torrejon Torres Rafael
Published: March 2024

Background: Crohn’s disease is a chronic ailment affecting the gastrointestinal tract. Mucosal healing, a marker of reduced disease activity, is currently assessed in the colonic sections using ileocolonoscopy and magnetic resonance enteroscopy. Video capsule endoscopy (VCE) offers visualization of the entire GI mucosae. Objective: To validate a Crohn’s disease model estimating the budget impact of VCE compared with the standard of care (SOC) in Italy. Methods: A patient-level, discrete-event simulation was developed to estimate the budget impact of VCE compared with SOC for Crohn’s disease surveillance over 5 years in the Italian setting. Input data were sourced from a physician-initiated study from Sant’Orsola-Malpighi Hospital in Bologna, Italy, and the literature. The care pathway followed hospital clinical practice. Comparators were the current SOC (ileocolonoscopy, with or without magnetic resonance enteroscopy) and VCE. Sensitivity analysis was performed using 500-patient bootstraps. A comparative analysis regarding clinical outcomes (biologics use, surgical interventions, symptom remission) was performed to explore the validity of the model compared with real-world data. Cumulative event incidences were compared annually and semi-annually. Bayesian statistical analysis further validated the model. Results: Implementing VCE yielded an estimated €67 savings per patient per year, with savings in over 55% of patients, compared with SOC. While annual costs are higher up to the second year, VCE becomes cost saving from the third year onward. The real-world validation analysis proved a good agreement between the model and real-world patient records. The highest agreement was found for biologics, where Bayesian analysis estimated an 80.4% probability (95% CI: 72.2%-87.5%) that a decision maker would accept the result as an actual reflection of real-world data. Even where trend data diverged (eg, for surgery [43.1% likelihood of acceptance, 95% CI: 33.7%-52.8%]), the cumulative surgery count over 5 years was within the margin of error of the real-world data. Conclusions: Implementing VCE in the surveillance of patients with Crohn’s disease and small bowel involvement may be cost saving in Italy. The congruence between model predictions and real-world patient records supports using this discrete-event simulation to inform healthcare decisions.
OCORRÊNCIA DE ERRO MÉDICO E A IMPORTÂNCIA DO PERITO VETERINÁRIO FORENSE NA ELUCIDAÇÃO DE CASOS: ESTUDO DE JULGADOS PELO TRIBUNAL DE JUSTIÇA DE SÃO PAULO NO PERÍODO DE 2018-2021
Authors: Silva Maria Raquel , Santos Robson Caetano dos , Siqueira Mônica Souza de , Nascimento Fernanda Eiras , Loures Thiago de Oliveira , Silva Maria Bernardete Oliveira Trajano da , Barros Jerlan Afonso da Costa , Souza Júlia Cristina Cardoso De , Silva Karine Pinheiro , Ferreira Wender Paulo Barbosa , Pinheiro Maria do Socorro Saraiva
Published: March 2024

O estudo presente aborda  casos de erros médicos veterinarios em âmbitos de atuação diferentes e as decisões desfavoráveis conforme estudo através de pesquisa do site do Tribunal de Justiça de São Paulo (TJSP), concernentes aos temas de "Erro Médico Veterinário”, “Perito Forense”, “Responsabilidade Civil”, “Prestação de Serviços”,  ocorrido no exercício dos anos entre 2018 a 2021. Sua finalidade reside na apreensão das principais lacunas e ramificações resultantes da omissão na utilização dos serviços de peritos judiciais e assistentes técnicos médicos-veterinários para orientação em julgamentos, visando à resolução substancial dos processos judiciais com  fundamento científico, cuja a notória capacitação sobre o tema é base imprescindível para alicerçar evidências periciais.
O CUIDADO DA SAÚDE DA MULHER NA GESTAÇÃO, PARTO E PUEPÉRIO
Authors: Fortes Rozinete de Oliveira Tavares , Nascimento Maria Eduarda Bezerra do , Laurindo Ashley Caymmi de Albuquerque , Santos Bárbara Letícia da Silva , Alves Maria Laura Fernandes , Duarte Pablo Dias , Lafetá Michelle Stefanny Fonseca , Neto Aluizio dos Santos , Aguiar Priscila Silva , Silva Esther Suellem Rocha , Ignácio Sara Carvalho , Pena Diogo Melo
Published: March 2024

A saúde da mulher durante a gravidez é tema de atenção atualmente, pois se relaciona às medidas sanitárias para prevenir doenças nesse período e garantir um parto saudável. As atividades do Ministério da Saúde centram-se na promoção e apoio às mulheres grávidas para prevenir doenças que afetam a saúde das mulheres e dos seus bebés. Os departamentos de saúde devem concentrar-se na introdução de estratégias de educação para a saúde, cuidados pré-natais, fornecimento de informação e proteção das mulheres grávidas. O objetivo deste estudo é mostrar os principais programas de apoio às gestantes e o conceito de cuidado materno por meio de atividades no setor para garantir a saúde da mulher. Escolhemos um método que utiliza uma abordagem de revisão de literatura, pesquisando Base de Dados de Enfermagem (BDENF), Biblioteca Eletrônica Científica Online (SCIELO), PubMed e Literatura em Ciências da Saúde da América Latina e do Caribe (LILACS). Selecionamos seis estudos para representar nossa compreensão sobre cuidados pré-natais publicados entre 2007 e 2024. Os resultados mostraram que a saúde materna, incluindo os cuidados pré-natais, identificou e tratou doenças durante a gravidez, o que atendeu às diretrizes do sistema nacional de saúde. Fica claro que para garantir um parto seguro, a recuperação da mãe e a recuperação do recém-nascido, as equipes de saúde devem estar totalmente preparadas para cuidar e apoiar a gestante.
A Formação de Educadores Ambientais a partir da perspectiva ecológica sistêmica
Authors: Noguez Janaina Amorim , Garcia Narjara Mendes , Bersch Angela Adriane Schmidt
Published: March 2024

Objetivamos nesse estudo realizar uma interlocução teórica entre a Educação Ambiental Sistêmica e a Teoria Bioecológica do Desenvolvimento Humano -TBDH -de Urie Bronfenbrenner com vistas a uma reflexão crítica das problemáticas socioambientais atuais e sua interface com a formação de educadores ambientais. Baseadas em uma metodologia de análise bibliográfica, apoiamo-nos em Sauvé (2005), Carvalho (2006), Loureiro (2004) e Boff (1999) quanto ao diálogo da Educação Ambiental Sistêmica. Capra (2005; 2006; 2008), Bertalanffy (1975) e Santos (2008) nos auxiliam na reflexão de uma emergente concepção de Ciência necessária à práxis em Educação Ambiental, a qual tem como objetivo final o equilíbrio nas relações entre humanos e o mundo natural com vistas à qualidade de vida de todos os seres. Como resultados, destacamos as contribuições de Guimarães (2004) quando defende os eixos formativos na formação de educadores ambientais. Tais eixos vão ao encontro do conceito de processo discutido pela TBDH, o que coaduna com a Educação Ambiental Sistêmica colocando esse campo do conhecimento para além de práticas pontuais, mas como processo reflexivo com vistas a concepções mais biocêntricas no que se refere às relações entre todos os seres.
Estudo das potencialidades do uso de objetos virtuais de aprendizagem no ensino da trigonometria
Authors: Petry Vitor José , Mohr Larissa Cassol , Moretto Augusto Morlin
Published: March 2024

Neste trabalho é apresentado um exercício de imaginação pedagógica, na perspectiva apresentada por Skovsmose, com a finalidade de investigar as potencialidades e possíveis contribuições de objetos virtuais de aprendizagem – OVA desenvolvidos com o software GeoGebra no estudo de conceitos relacionados à trigonometria. A pesquisa foi desenvolvida a partir de uma atividade proposta no componente curricular de Metodologia de Ensino em um curso de Licenciatura em Matemática. Foi proposta e apresentada uma sequência didática a partir do desenvolvimento dos OVA, visando a aprendizagem dos conceitos relativos ao objeto de estudo. A partir das discussões e do feedback da turma, foram realizados alguns ajustes nos OVA e desenvolvido o estudo de possibilidades. Foram identificadas evidências de que o uso dos OVA podem auxiliar no processo de aprendizagem e na compreensão de conceitos e propriedades da trigonometria por parte dos alunos.
Uso de fanzines em aulas de Ciências: uma revisão sistemática de literatura
Authors: Rodrigues Jéssyka Melgaço , Leite Raquel Crosara Maia
Published: March 2024

O objetivo da pesquisa foi desenvolver uma Revisão Sistemática de Literatura (RSL) acerca da utilização de fanzines nas aulas de ciências. A investigação, de caráter secundário, estabeleceu a seguinte questão norteadora: “qual o cenário das pesquisas existentes no Brasil, sobre o uso de fanzines para o Ensino de Ciências, observando-se os últimos anos (2017-2022)?”, bem como ordenou a definição de protocolos específicos para a busca de publicações contidas em ambientes virtuais. As dez produções científicas incluídas nesta revisão foram extraídas de três diferentes repositórios digitais e, posteriormente, examinadas em profundidade. Os resultados mostram que o Ensino Fundamental apareceu como o principal segmento educacional em que os fanzines foram implementados nas aulas de ciências, em geral, para abordar assuntos relacionados a doenças e impactos ambientais. Além disso, constatou-se que os fanzines são recursos didáticos multifacetados, que podem ser elementos-chave em um processo de ensino-aprendizagem, mas é pertinente considerar sua associação com outras ferramentas e práticas de ensino, visando ampliar ainda mais seu repertório de potencialidades pedagógicas. O conteúdo das publicações que compuseram a RSL permitiu, portanto, a coleta de importantes elementos qualitativos e quantitativos sobre o uso de fanzines no contexto do ensino de ciências.
SORPTION ISOTHERM AND QUALITY ASSESSMENT OF CHICKEN JERKY
Authors: Oluwatoyin Folake Alamuoye  , Nathaniel Olu Alamuoye  , Lawrence Kunle Otitoju
Published: March 2024

This study investigated the sorption isotherm, proximate composition, lipid oxidation, and sensory evaluation of chicken jerky. The moisture adsorption behavior was analyzed using a gravimetric method while proximate analysis was performed according to official methods. Lipid oxidation was measured by thiobarbituric acid reactive substances (TBARS) assay while sensory evaluation was conducted with trained panelists based on appearance, taste, odor, texture, and overall acceptability. Results showed that equilibrium moisture content increased as water activity increased from 0.043 to 0.750 but remained relatively constant at 0.843 to 0.973 aw. Proximate analysis revealed that the protein content of chicken jerky was high (76.13) while a low-fat content (1.72%) was obtained in this study. Sensory evaluation indicated that overall acceptability was highly dependent on texture followed by aroma and flavour. Based on these results it can be concluded that factors such as formulation, processing method, ingredient quality and raw meat quality greatly influence the physicochemical properties of chicken jerky which ultimately affects consumer acceptance.
KEYWORDS: Aroma, Humidity, Salt,Shelf-life, Snack, Storage
SYNTHESIS, SPECTROPHOTOMETRIC AND CHROMATOGRAPHY TECHNIQUES OF CRUDE OIL AND PETROLEUM PRODUCTS
Authors: Santosh Namdeo Upare  , Dr. J. Sai Chandra
Published: March 2024

Crude oil and petroleum products are important natural resources that have significant economic and environmental implications. Crude oil is a complex mixture of hydrocarbons that is extracted from the ground and refined to produce various petroleum products, including gasoline, diesel, and jet fuel. The composition of crude oil and petroleum products can vary widely depending on the source and the refining process used. Accurate characterization of these substances is essential for evaluating their quality, properties
A Needs Analysis for The Game-Based Learning Tools Development for Form Four Chemistry Subject
Authors: Mat Napes Marlina , Mohamad Sharif Aisyah
Published: March 2024

This study was conducted specifically to identify the problems faced by students and teachers in mastering the salt preparation content standard (CS) and to identify the needs to develop a Game-Based Learning (GBL) tool for the CS. The research approach is quantitative method using survey design. The researchers prepared a survey using the Google Forms and disseminated it randomly using Telegram and WhatsApp applications. Two hundred twenty-four (224) students and two hundred and seven (207) teachers in Malaysia mainly in Selangor, Kuala Lumpur and Perak responded to the survey. Data has been analysed descriptively. The survey results revealed that 80.4% students and 86.5% teachers agreed on the difficulty in learning the preparation of salts CS. Difficulties stated by students were too many facts to remember (86.1%), having difficulty answering experimental questions related to salt CS (77.2%) and practical implementation in school less helpful in mastering salt preparation method completely (75%). Teachers also agreed that the experimental activities conducted did not guarantee students’ understanding of the salt CS (75.8%) and students failed to answer questions related to experiments on the salt CS (78.3%). Besides, 87.9% of students and 84.5% of teachers agreed to incorporate the game-based learning method. The survey showed students chose the type of game through smartphones (62.1%), board games (51.8%) and card games (49.6%). In contrast to teachers, namely card games (66.7%), board games (58.5%) and smartphones (54.1%). The need analysis study conducted has helped the researchers to identify the types of game-based learning tool, which is pre-laboratory activity with combination of board and card games. The research produced can guide educators produce teaching tools that are appropriate to the problems and needs of students today.
Need Analysis Development of Game-based Training Modul for Form One Topic in Geometry Field
Authors: Mohammad Aidie Ikhwan , Raja Maamor Shah Raja Lailatul Zuraida
Published: March 2024

The design and development research approach needs analysis needs to be conducted to identify the need to develop a product. This survey study was conducted to identify students' perceptions on the use of game-based training modules in the teaching and learning process and to identify the need for the development of a game-based training module for form one geometry topics. A set of needs analysis questionnaires was administered to 457 form one students from 3 secondary schools under the administration of the Kota Bharu District Education Office (PPD). The data obtained were analyzed using SPSS software (Statistical Package for The Social Sciences) version 27.0. The results of the descriptive analysis showed that students' perceptions of the use of game-based training modules were at satisfying level. Subsequent findings also show a high percentage of the need for game -based training modules for the topic of geometry form one that is 85.5% of respondents agreed that training modules should be developed while only 15.5% disagreed. The results of this study indicate that the need for a game-based module in the teaching and learning process of form one geometry and the majority of respondents showed a high desire for the use of game-based training modules in the teaching and learning process in schools.
Rovatszerkesztői bevezető – A didaktika a digitális tananyagok és tanulási környezetek fejlesztésében
Authors: Fűzi Beatrix , Horváth László
Published: March 2024

Folytatjuk a didaktika jelentőségét fontolgató sorozatunkat. Rovatunk legfrissebb írása a didaktika e-learning-tananyagok és tanulási környezetek fejlesztésében betöltött szerepét járja körül. Rámutat, hogy a színvonalas, tanulási célok elérését megfelelően szolgáló e-learning fejlesztések a tanulói sajátosságok alapos ismeretére és az ezekkel összehangolt módszertani megoldásokra épülnek. Szerzőnk megfogalmazza, hogy az e-learning fejlesztők kreatív munkájának biztos alapjait egy koherens általános didaktika teremtheti meg. A sorok között olvasva felfedezhető, hogy az e-learning fejlesztések tapasztalatai milyen irányokat kínálnak a didaktika és a tankönyvek jövőbeli fejlesztéséhez. Várjuk Olvasóink véleményét, reflexióit az írásokra és a felvetett kérdésekre!
Public-Private Partnership and Early Childhood Education in Kasese District, Uganda
Authors: Kategaya Raymond Mwesigye , Adyanga Akena Francis , Ocan Johnson
Published: March 2024

The article’s main purpose was to investigate the relationship between public-private partnership (PPP) and early childhood education in Kasese District, Uganda. The main objectives of the study were to establish the role played by public-private partnerships in making certain that children develop numerical skills and expressive communication abilities. The study was conducted through an Ex Post Facto design study design. The target population of the study was stakeholders for early childhood education in Kasese District, Western Uganda. To ensure fair representation, research subjects were selected from each stratum of stakeholders. The scholar thus used stratified and, later on, random sampling techniques. The sample selected had 312 respondents from an estimated total number of 1.417 ECD stakeholders in Kasese District. Primary data was collected by administering a questionnaire that was designed on a 5-point Likert Scale, ranging from strongly agree to strongly disagree. Face-to-face interviews and an observation checklist were also used in the collection of data. Data collected was presented and analysed with frequency distribution and percentages while the corresponding hypothesis was tested with Chi-square statistic at 0.05 alpha levels. It was found the PPP in ECDs helped in the improvement of numeracy among children. For instance, stakeholders’ work helped in improving children’s counting of fingers on one hand or even copying and drawing shapes amongst young ones. Similarly, respondents indicated that Policy Guideline Formulation due to PPP led children to sort objects by colour and shape. Also, results showed that PPP in ECD enhanced communication ability whereby children were able to put up two words together as per caregiver guidance. It also led a child to pay attention to a simple story being narrated and thereafter answer questions from the account. Similarly, it was also found that Institutional Factors for PPP supported expressive ability in children in that they were in a position to follow a simple command. Besides, the availability of suitable Home Environment Factors was also found to promote communication ability in children. Thus, the study concluded that public-private partnership plays a part in ensuring that children develop numerical concepts. It was also concluded that public-private partnership plays a role in making certain that children develop expressive communication abilities
Return-to-play decision-making following ankle injury: a comprehensive case analysis of the functional hop test
Authors: Crinion Michael , Ball Andrew , Agnone Michael
Published: March 2024

Following anterior cruciate ligament (ACL) injury of the knee, the functional hop test (an averaging of 4 component hop tests including single-hop, triple-hop, cross-over-hop, and 6-meter-hop) is commonly used by sports medicine physicians, doctors of physical therapy, and athletic trainers in return-to-practice and return-to-play decision making. In this case report, the functional hop test was applied to a 31-year-old recreational basketball player status-post full-tear of the anterior talofibular ligament (ATFL) to examine the applicability of a standardized, efficient, and easy-to-administer functional test in making return-to-play decisions following an ankle injury. The functional hop test was administered 5 times across a treatment course of 11 physical therapy sessions emphasizing pain-free range of motion, baseline strength, weight-bearing loading, and sport-specific training. The functional hop test was found to be a helpful (albeit imperfect) tool for clinical decision-making following an ankle injury. Specifically, improvements in landing skill/confidence of single hop accounted for the greatest gains in total score in the early phase of rehabilitation, while momentum and plyometric skill/control of triple hop accounted for the greatest gains in total score in the later phase of rehabilitation. Modification of the functional hop test to include sub-component tests of strength, endurance, and/or lateral hops are discussed.
Visiting Professor As Implementation Of Cooperation Between Universitas Islam Negeri Sultan Syarif Kasim Riau And Arkalyk Pedagogical Institute, Kazakhstan
Authors: Hamzah Muhammad Luthfi , Nazaruddin Nazaruddin , Saule Baizakova , Perizat Azhibekova , Medet Ilubaev , Ainur Sundetbaeva , Zhannar Baisoteva
Published: March 2024

Visiting Professor Program (VIPP) is a program to send PTAI professors to universities / research institutions abroad with a maximum duration of 1 month, facilitating PTAI permanent lecturers with the title of Professor to develop their ideas and ideas through joint research, updating teaching materials and learning methods in accordance with the latest developments in the world of international education, developing curriculum studies, comparative studies of institutional management management,  and become a guest examiner for students of overseas partner universities. Purpose of Visiting Professor Program (VIPP) Increasing PTAI institutional competitiveness towards a world class university through cooperation and partnership with foreign universities / institutions, Development of competence of PTAI professors in the fields of research, academic writing and networking abroad through scientific presentations, research, benchmarking, publishing manuscripts in reputable international journals Socialization and internationalization of Nusantara Islamic studies. This VP program is an implementation of international cooperation between UIN Sultan Syarif Kasim and Arkalyk Pedagogical Institute, Kazakhstan. This highly talented young lecturer and reviewer of several international journals indexed by Scopus is listed as the only lecturer from the State Islamic Religious College (PTKIN) in Indonesia teaching at the university.
Improve the Electric Power Generation Issue by Cognitive Thinking
Authors: Dhamanda Ashish
Published: March 2024

The enormous increase in power demand due to the prevalent heat wave, the worst power shortage in the last decades, and lack of sufficient fossil fuels like natural gas, coal, oil, etc. has attracted the attention of researchers worldwide. One of the main reasons behind the problem is the mismanagement of proper regulation of the electrical power generation unit. This paper looks at cognitive thinking to address and improve this issue by noting that it is the process of gaining knowledge and understanding through thought, experience, and the senses that have enabled researchers to infer cognitive processes. Highly controlled and rigorous methods of study have always been employed to enable the work. Thermal energy power plants have been taken as the source of power generation and genetic algorithm (GA), fuzzy, and PID (Proportional, Integral, Derivative) controllers are used. All these controllers handle and control sudden changes in load frequency and power. For better and more effective results of the system, combined feedback has been obtained with the help of MATLAB Simulink software. The results obtained from the combined feedback are tabulated, which shows that all the controllers improve the electrical power generation issue by modulating the changes in load frequency and power, but the GA controller produces effective, efficient, and better results by adjusting to the changes in less time. The use of this cognitive thinking of the controller helps in the proper management of power demand which automatically improves and controls the power generation.
Adenosquamous Carcinoma in the Epithelial Inclusion Cyst of The Vagina — A Rare Clinical Case Report
Authors: Гребенкин Евгений Валерьевич , Кондрашова Любовь Михайловна , Untesco Maxim , Епишкина Анна Алексеевна , Кещьян Карен Суренович
Published: March 2024

Плоскоклеточный рак является наиболее часто встречающимся злокачественным новообразованием влагалища, составляя от 80 % до 90 % случаев; аденокарцинома встречается до 10 % случаев. В то же время в литературе описаны единичные случаи аденоплоскоклеточного рака данной локализации. Аналогично более изученному аденоплоскоклеточному раку шейки матки, развитие данной опухоли влагалища связывают с онкогенными штаммами вируса папилломы человека. Эпителиальная инклюзионная киста влагалища является крайне редким источником опухолевого роста. В 2012 г. сообщалось о первом в мире зарегистрированном случае обнаружения плоскоклеточного рака в плоскоклеточной инклюзионной кисте влагалища.
Заключение. Анализ доступной отечественной и зарубежной литературы позволяет нам констатировать, что представленный нами случай, вероятно, является первым опубликованным случаем аденоплоскоклеточного рака в инклюзионной эпителиальной кисте влагалища.
A Case of Keratinizing Squamous Cell Carcinoma of the Lung with Myocardial Carcinomatosis
Authors: Альпидовская Ольга Васильевна
Published: March 2024

Введение. Рак лёгкого является распространённым злокачественным новообразованием и занимает первое место в структуре онкологической смертности. Длительное отсутствие клинических признаков приводит к поздней обращаемости за медицинской помощью. В связи с актуальностью проблемы, представляется случай плоскоклеточного ороговевающего рака легкого с канцероматозом миокарда.
Описание случая. Больной 65 лет, умерший в домашних условиях, доставлен на патологоанатомическое вскрытие. При секционном исследовании в нижнедолевом бронхе правого легкого имелся участок с муфтообразным перибронхиальным ростом опухоли. При гистологическом исследовании выявлялись опухолевые участки с нечетким послойным расположением клеток. В зоне инвазии отмечались ороговевающие элементы с пикноморфным ядром и обильной ацидофильной цитоплазмой. В миокарде выявлялись скопления атипичных клеток. В полости правого предсердия отмечался пристеночный опухолевый тромб. Гистологически в сердце отмечались признаки острой сердечно-сосудистой недостаточности и тампонада сердца.
Заключение. Выявленный рак нижнедолевого бронха правого легкого (гистологический вариант: плоскоклеточный ороговевающий рак низкой степени дифференцировки) характеризовался отсутствием характерных метастазов в лимфатические узлы. Отмечался канцероматоз миокарда.
The Effect of Propylthiouracil on the Life Expectancy of the Rats with C6 Glioma
Authors: Чернов Александр Николаевич , Прозоренко Евгений Владимирович , Севян Надежда Вагаршаковна , Галимова Эльвира Сафуановна , Давыдов Михаил Михайлович , Митрофанов Алексей Андреевич , Глушаков Руслан Иванович
Published: March 2024

Цель — изучить влияние тиреостатика пропилтиоурацила (ПТУ) на продолжительность жизни крыс с глиомой С6.
Материалы и методы. Моделирование опухоли головного мозга in vivo выполняли с помощью внутримозговой стереотаксической имплантации крысам (n = 32) клеток глиомы С6. Животных рандомизировали на 2 группы в соотношении 9:7. На крысах экспериментальной группы (n = 18) моделировали гипотиреоз путем перорального зондового введения пропилтиоурацила 15 мкл на животное 1 раз в сутки.
Результаты. Введение припилтиоурацила достоверно (χ2 = 16,91, p = 0,001) на 63,16 % увеличивает продолжительность жизни крыс (n = 18, 16,0 ± 2,37 сут.) по сравнению с контролем (n = 14, 10,0 ± 4,2 сут.) и уменьшает риск их летального исхода (HR = 0,14, 0,05-0,38).
Выводы. Введение пропилтиоурацила увеличивает продолжительность жизни крыс с глиомой С6 и уменьшает риск летального исхода.
Expression of Gankyrin in Colon Cancer Tissues, Association with Clinical and Morphological Parameters of the Tumor
Authors: Азовский Даниил Игоревич , Спирина Людмила Викторовна , Афанасьев Сергей Геннадьевич , Августинович Александра Владимировна , Доспан Азияна Буяновна , Чебодаева Анастасия Владимировна
Published: March 2024

Введение. В настоящее время большое значение придается белку ганкирину, который первоначально был идентифицирован как компонент 26S протеасомы. Роль ганкирина как опухолевого онкогена была установлена при различных типах рака человека. Цель исследования заключалась в изучении экспрессии ганкирина в опухоли ободочной кишки, в связи с экспрессией транскрипционных, ростовых факторов и компонентов AKT/mTOR сигнального пути.
Материал и методы. В исследование было включено 56 пациентов с колоректальным раком в возрасте от 43 до 75 лет (средний возраст составил 54 года). Пациенты получали комбинированное лечение, которое включало неоадъювантную химиотерапию по схеме FOLFOX, либо XELOX, а также хирургическую резекцию пораженного участка кишки в клиниках НИИ онкологии Томского НИМЦ. Экспрессия ганкирина, транскрипционных, ростовых факторов и компонентов AKT/mTOR сигнального пути определяли методом ПЦР в реальном времени.
Результаты. При наличии отдаленных метастазов заболевания отмечено снижение экспрессии ганкирина в 2,4 раза по сравнению с больными со стадией заболевания T1-2N0-2M0. Экспрессия ганкирина в высокодифференцированных опухолях снижалась в 4,3 и 2,9 раза соответственно, по сравнению с умереннодифференцированными и низкодифференцированными опухолями. При наличии стойкой стабилизации опухолевого процесса уровень мРНК ганкирина снижался в 4,0 раза по сравнению с пациентами с частичной регрессией. Отмечается рост экспрессии 70S 6 киназы, NF-kB p50 и PD-1 в 3,2; 5,2 и 41,0 раза у больных с повышенной экспрессией (> 1,0 Усл. Ед.) на фоне снижения экспрессии VHL в 51,1 раза по сравнению с пациентами с пониженной экспрессией ганкирина.
Выводы. Выявлены особенности экспрессии ганкирина, транскрипционных, ростовых факторов, компонентов AKT/mTOR сигнального пути, рецепторов и лигандов программированной клеточной гибели, степенью дифференцировки опухоли, а также ответом опухоли на проведённое лечение.
Refractive symmetry analysis of fellow eyes
Authors: Saha sankha Jyoti , Dev Dr Kapil , Dutta Pratyay Ranjan
Published: March 2024

The biological structure of human body frequently exhibit symmetry. The hypothesis of refractive symmetry assumes that the two eyes of an individual should have homogeneous refractive properties. Optometry clinical management mostly rely upon meridional magnification effect, spatial distortion, and binocular spatial perception while prescribing refractive correction. Additionally, bilateral symmetry analysis approach has proven very informative for better diagnosis. This study was multi-centered, cross-sectional, analytical, and retrospective, where we studied refractive errors with conventional clinical notation using the sphere, cylinder, and axis. The collected data were scrutinized using the SPSS, Minitab Statistical Software. In inter-ocular symmetry analysis, if the numerical difference between both axes is zero, Equal Octant or Direct Symmetry is to be considered. While, with Mirror Octants or Mirror Symmetry or Enantiomorphism, the axes difference is not zero, but the portrayal of the figures are reverberatory. 53.23% and 70.15% of the cases rooted in the Equal Octant and Mirror Octant pattern respectively, within 15° of absolute symmetry. Analysis showed that age between 7 to 14 years has the lowest inter-ocular axis difference with both the models. The average difference in inter-ocular axis was significantly reduced in the isorule group compared to the anisorule group, as observed in both direct and mirror symmetry models. Interval plot shows a lower interval proximity for Mirror Octant, in compare to Equal Octant. We tracked down that isorule bilateral astigmatism dominates the study population. Whereas, Mirror Octant is more periodic than Equal Octant.
Determining by Raman spectroscopy the average thickness and N-layer-specific surface coverages of MoS2 thin films with domains much smaller than the laser spot size
Authors: Wasem Klein Felipe , Huntzinger Jean-Roch , Astié Vincent , Voiry Damien , Parret Romain , Makhlouf Houssine , Juillaguet Sandrine , Decams Jean-Manuel , Contreras Sylvie , Landois Périne , Zahab Ahmed-Azmi , Sauvajol Jean-Louis , Paillet Matthieu
Published: March 2024

Raman spectroscopy is a widely used technique to characterize nanomaterials because of its convenience, non-destructiveness, and sensitivity to materials change. The primary purpose of this work is to determine via Raman spectroscopy the average thickness of MoS2 thin films synthesized by direct liquid injection pulsed-pressure chemical vapor deposition (DLI-PP-CVD). Such samples are constituted of nanoflakes (with a lateral size of typically 50 nm, i.e., well below the laser spot size), with possibly a distribution of thicknesses and twist angles between stacked layers. As an essential preliminary, we first reassess the applicability of different Raman criteria to determine the thicknesses (or layer number, N) of MoS2 flakes from measurements performed on reference samples, namely well-characterized mechanically exfoliated or standard chemical vapor deposition MoS2 large flakes deposited on 90 ± 6 nm SiO2 on Si substrates. Then, we discuss the applicability of the same criteria for significantly different DLI-PP-CVD MoS2 samples with average thicknesses ranging from sub-monolayer up to three layers. Finally, an original procedure based on the measurement of the intensity of the layer breathing modes is proposed to evaluate the surface coverage for each N (i.e., the ratio between the surface covered by exactly N layers and the total surface) in DLI-PP-CVD MoS2 samples.
Analisis Implementasi Potensi Lokal dalam Pembelajaran Ilmu Pengetahuan Alam
Authors: Reka Nurjanah  , Shinta Purnamasari  , Andinisa Rahmaniar
Published: March 2024

Potensi daerah adalah potensi sumber daya khusus suatu daerah yang terdiri dari sumber daya alam, manusia, teknologi serta budaya yang dapat dikembangkan untuk menciptakan kemandirian nasional. Artikel ini bertujuan untuk memaparkan hasil analisis berupa kajian literatur mengenai implementasi potensi lokal pada pembelajaran IPA serta dampaknya. Kajian literatur dilakukan pada 25 artikel yang telah dipublikasikan di berbagai jurnal dari tahun 2016-2023. Kajian literatur dilakukan dengan empat tahapan diantaranya mencari informasi berupa artikel sesuai dengan topik yang akan di review, melakukan pencarian mengenai artikel yang sesuai dengan topik yang sudah ditentukan, melakukan analisis dan sintesis pada jurnal yang telah di pilih serta melakukan organisasi tulisan. Hasil dari kajian pustaka dan analisinya menunjukkan bahwa 1) Potensi lokal dalam pembelajaran IPA dapat diimplementasikan pada berbagai bentuk yakni perangkat pembelajaran, e-modul pembelajaran, bahan ajar, modul pembelajaran, e-learning, ensiklopedia, dan media pembelajaran. 2) Implementasi potensi lokal dalam pembelajaran IPA memberikan dampak yang baik yaitu dapat meningkatkan hasil belajar serta keterampilan-keterampilan siswa yaitu berpikir kritis, keterampilan proses sains dan sikap peduli lingkungan. Penelitian analisis potensi lokal pada pembelajaran IPA menunjukkan bahwa pembelajaran lebih bermakna serta dapat menumbuhkan kesadaran dalam menjaga kekayaan potensi lokal dan sikap peduli terhadap lingkungan sekitar. Penelitian ini diharapkan agar dapat menjadi referensi bagi peneliti dalam melakukan dan menentukan tema penelitian yang akan diambil yang berhubungan dengan potensi lokal pada pembelajaran IPA.
MHD Slip Flow of Upper-Convected Casson and Maxwell Nanofluid over a Porous Stretched Sheet: Impacts of Heat and Mass Transfer
Authors: V.Seethamahalakshmi  , Leelavathi Rekapalli  , T.S.Rao  , P.Naga Santoshi  , G.V.R.Reddy  , Oke A.S
Published: March 2024

The significance of this study lies in the exploration of the effects of thermal radiation and convective boundaries on magnetohydrodynamic slip flow over a nonlinear porous stretching surface. Applications range from aiding heat transfer enhancement in electronic devices and renewable energy systems to facilitating understanding in magnetic confinement fusion research and liquid metal cooling systems. The primary goal of this study is to determine how thermal radiation and convective boundaries affect the upper Maxwell Casson convected nanofluid boundary layer flow's magnetohydrodynamic slip flow over a nonlinear porous stretching surface. From the controlling PDEs, nonlinear ODEs are obtained by applying compatible similarity transformations. The quantities related to scientific and engineering concepts, such as skin friction, Sherwood number, and heat exchange, as well as other effects on momentum, temperature, and material concentration, are shown and explained in diagrams. The numerical solution of the current study and the shooting technique is achieved using the Runge-Kutta Fehelberg method. According to the results, increasing the magnetic field causes a decrease in velocity profiles. Additionally, as the velocity slip parameter increases, the local Nusselt number and the local Sherwood number fall.
Основы нанотехнологий: инновационные решения в анализе для биообъектов
Authors: Kuchmenko T. A. , Umarkhanov R. U.
Published: March 2024

Учебное пособие разработано в соответствие с требованиями ФГОС ВО подготовки выпускников по специальностям 04.05.01 – «Фундаментальная и прикладная химия» и 06.05.01 – «Биоинженерия и биоинформатика». Предназначено для закрепления теоретических и практических знаний дисциплины «Основы нанотехнологий». В учебном пособии представлен материал по определению важнейших показателей качества биообъектов разной природы с применением инновационных аналитических решений и приборов искусственного обоняния («электронный нос»). Приведены задания для самоподготовки, даны описание лабораторных работ и анализ результатов.
PERSEKUTUAN BANSER DAN APARAT NEGARA DALAM PERISTIWA NINJA DI JAWA 1998-1999 M
Authors: Zakiyatul Khusna  , Abdur Rahman  , Fathul Qorib
Published: March 2024

This research analyzes the contribution of Barisan Ansor Serbaguna (Banser) in dealing with ninja incidents that occurred in society in 1998-1999. The main focus of the research is on the correlation of interactions between Banser and state officials in responding to and resolving the ninja incident in 1998. Using qualitative research, this research explores information through in-depth interviews, data documents, and analysis of related documents. The main findings show that Banser had a significant role in maintaining societal stability during the Ninja incident. Cooperation between Banser and state officials had a positive impact in dealing with the crisis. A good correlation between the two increases the effectiveness of preventive and responsive actions, which ultimately helps restore social order. This provides deeper insight into the role of security organizations such as Banser in supporting the tasks of state officials in facing complex challenges at the community level. The implications of these findings can be a basis for developing better collaborative strategies between community organizations and government in overcoming similar crisis situations in the future.
BERZIARAH KE MAKAM SYEKH YUSUF AL-MAKASSARI
Authors: Azis Muhammad Nur Ichsan
Published: March 2024

The study investigates the implications of undertaking a pilgrimage to the tomb of Syekh Yusuf Al-Makassari, whose significant contributions have profoundly shaped Islamic thought and civilization. Following his passing, his burial site has become a crucial destination for pilgrims, leading to socio-economic effects on the surrounding community. Employing historical methodologies within a socio-economic framework, the research aims to elucidate the socio-economic conditions of the community surrounding Sheikh Yusuf Al-Makassari's tomb. Recognized as a pivotal figure and scholar in Indonesian history and beyond, Sheikh Yusuf's enduring influence is evident through the influx of pilgrims from diverse regions to his gravesite, highlighting his ongoing societal significance. The findings of this study reveal various social and economic aspects, including the financial status of the local population, employment opportunities, and microeconomic dynamics.
From the Frying Pan to the Fire - Life as a Foundation Year One
Authors: Chakravorty Triya Anushka
Published: March 2024

Reflections on the trials and tribulations of a first year junuior doctor - the highs and the lows.
Two new species of Sordariomycetes (Chaetomiaceae and Nectriaceae) from China
Authors: Wang Hai-Yan , Li Xin , Dong Chun-Bo , Zhang Yan-Wei , Chen Wan-Hao , Liang Jian-Dong , Han Yan-Feng
Published: March 2024

Rich and diverse fungal species occur in different habitats on the earth. Many new taxa are being reported and described in increasing numbers with the advent of molecular phylogenetics. However, there are still a number of unknown fungi that have not yet been discovered and described. During a survey of fungal diversity in different habitats in China, we identified and proposed two new species, based on the morphology and multi-gene phylogenetic analyses. Herein, we report the descriptions, illustrations and molecular phylogeny of the two new species, Bisifusarium keratinophilumsp. nov. and Ovatospora sinensissp. nov.
Systematic revision of the Calotes jerdoni complex (Reptilia: Squamata: Agamidae) in the Pan-Himalaya
Authors: Wang Kai , Deepak V. , Das Abhijit , Grismer L. Lee , Liu Shuo , Che Jing
Published: March 2024

Abstract

Owing to the harsh terrain, few biodiversity surveys have been carried out in the Pan-Himalaya Region. Among the understudied taxa from this region, Jerdon’s forest lizard, Calotes jerdoni, is believed to have a wide distribution, from northeast India to southwestern China. However, given the heterogeneous environment across its range and the lack of studies on this species, its taxonomy remains questionable. Using integrative taxonomic methods, we combined both morphological and genetic data from the type and topotypic specimens and examined the current taxonomic hypothesis of C. jerdoni across its range. Molecular data reveal that C. jerdoni as currently recognized, contains three deeply diverged lineages: one from the type locality in Northeast India, one from Western Myanmar, and another one from Southwestern China. The uncorrected genetic distances of mitochondrial coding gene ND2 among these three clades ranged over 10%. The Chinese population is sister to C. medogensis and paraphyletic to the remaining two clades of C. jerdoni. Morphological analyses confirm the results of the molecular analyses, where the Myanmar and Chinese populations can be diagnosed statistically in both univariate and multivariate space from the true C. jerdoni, as well as by a suite of reliable categorical morphological characters, including the size and shape of gular scales and ventral scales. To resolve the current taxonomic confusion, we resurrect the junior synonym, C. yunnanensis, for the Chinese population and expand its distribution to Myanmar, redescribe the elusive C. maria and C. medogensis based on its type material, and describe the remaining western Myanmar population as a new species. We further discuss the possibility of additional cryptic species within the complex in the Pan-Himalaya Region and provide a diagnostic key to all recognized members of the C. jerdoni complex.
Expérience libertarienne en Argentine
Authors: Perrot Étienne
Published: March 2024

Les récentes élections argentines ont mis en valeur le courant « libertarien », peu connu en Europe. Il plaide pour une généralisation du marché et un État minimal dans un mélange d’anarcho-capitalisme et de populisme. Les premières mesures du président Javier Milei vont dans cette direction. Il n’est pas certain que leur succès soit assuré. Dans un nombre croissant de sociétés, l’idéologie du libre marché est contestée pour ses conséquences négatives sur la cohésion sociale.
IOOA: A multi-strategy fusion improved Osprey Optimization Algorithm for global optimization
Authors: Wen Xiaodong , Liu Xiangdong , Yu Cunhui , Gao Haoning , Wang Jing , Liang Yongji , Yu Jiangli , Bai Yan
Published: March 2024

With the widespread application of metaheuristic algorithms in engineering and scientific research, finding algorithms with efficient global search capabilities and precise local search performance has become a hot topic in research. The osprey optimization algorithm (OOA) was first proposed in 2023, characterized by its simple structure and strong optimization capability. However, practical tests have revealed that the OOA algorithm inevitably encounters common issues faced by metaheuristic algorithms, such as the tendency to fall into local optima and reduced population diversity in the later stages of the algorithm's iterations. To address these issues, a multi-strategy fusion improved osprey optimization algorithm is proposed (IOOA). First, the characteristics of various chaotic mappings were thoroughly explored, and the adoption of Circle chaotic mapping to replace pseudo-random numbers for population initialization improvement was proposed, increasing initial population diversity and improving the quality of initial solutions. Second, a dynamically adjustable elite guidance mechanism was proposed to dynamically adjust the position updating method according to different stages of the algorithm's iteration, ensuring the algorithm maintains good global search capabilities while significantly increasing the convergence speed of the algorithm. Lastly, a dynamic chaotic weight factor was designed and applied in the development stage of the original algorithm to enhance the algorithm's local search capability and improve the convergence accuracy of the algorithm. To fully verify the effectiveness and practical engineering applicability of the IOOA algorithm, simulation experiments were conducted using 21 benchmark test functions and the CEC-2022 benchmark functions, and the IOOA algorithm was applied to the LSTM power load forecasting problem as well as two engineering design problems. The experimental results show that the IOOA algorithm possesses outstanding global optimization performance in handling complex optimization problems and broad applicability in practical engineering applications.
A new design method to global asymptotic stabilization of strict-feedforward nonlinear systems with state and input delays
Authors: Jiang Mengmeng , Niu Xiao
Published: March 2024

This paper studies the global asymptotic stabilization problem of strict-feedforward nonlinear systems with state and input delays. We will first transform the considered system into an equivalent system by constructing the novel parameter-dependent state feedback controller and introducing the appropriate coordinate transformation. After that, the global asymptotic stability of the closed system is proved by giving the proper Lyapunov-Krasovskii functional and using the stability criterion of time-delay system.
Public investment as a growth driver for a commodity-exporting economy: Sizing up the fiscal-monetary involvement
Authors: Shvets Serhii
Published: March 2024

The study presents a solution to maximize public investment as a growth driver for commodity-exporting economies. The solution is to compensate for the low efficiency of public investment by drawing on internal and external factors within an active fiscal and monetary policy framework. For this, the paper introduces a quantitative model that implements a golden rule of public finance in a resource boom backed by a sovereign wealth fund under an active monetary policy stance. The modeling results show that mobilizing windfall resource revenues to finance increased public investment can limit a crowding-out effect through proper resource allocation and change the sectoral structure in favor of the final goods sector. As confirmed by the sensitivity analysis, the low efficiency of public investment can be partially offset by a less restrictive monetary policy response to fiscal dominance, but this leads to excessive volatility in financial indicators. However, if the public debt burden is an issue due to a more robust fiscal dominance regime, a higher tax rate on exported raw materials can be used to maintain sustainability. By developing a policy goals domain, the paper initiates a discussion that can direct policy recommendations toward a promising growth path by maximizing the public investment driver in the complex policy environment of fiscal-monetary interaction.