bluuebunny/crossref_metadata_2025 huggingface dataset:
Second Edition of the German–Austrian S3 Guideline “Infarction-Related Cardiogenic Shock: Diagnosis, Monitoring and Treatment”
Authors: Pilarczyk Kevin , Boeken Udo , Russ Martin , Briegel Josef , Buerke Michael , Geppert Alexander , Janssens Uwe , Kelm Malte , Michels Guido , Schlitt Axel , Thiele Holger , Willems Stephan , Zeymer Uwe , Zwissler Bernhard , Delle-Karth Georg , Ferrari Markus Wolfgang , Figulla Hans Reiner , Heller Axel , Hindricks Gerhard , Pichler-Cetin Emel , Pieske Burkert , Prondzinsky Roland , Bauersachs Johann , Kopp Ina , Werdan Karl , Thielmann Matthias
Published: March 2024

The mortality of patients with MI has significantly decreased in recent decades, mainly due to early reperfusion therapy with a probability of surviving of more than 90% if the patient reaches the hospital [...]
Smart Glasses for Cultural Heritage: A Survey
Authors: Trichopoulos Georgios , Konstantakis Markos , Caridakis George
Published: March 2024

This paper presents a comprehensive survey on the utilization of smart glasses in the context of cultural heritage. It offers a systematic exploration of prevailing trends, the latest state-of-the-art technologies, and notable projects within this emerging field. Through a meticulous examination of diverse works, this study endeavors to categorize and establish a taxonomy, thereby facilitating a structured analysis of the current landscape. By distilling key insights from this categorization, the paper aims to draw meaningful conclusions and provide valuable insights into the potential future trajectory of SGs technology in the realm of CH preservation and appreciation.
pXRF and Polychromy: Identifying Pigments on Limestone Statuary from the Roman Limes, Preliminary Results
Authors: Campbell Louisa , Hack Charleen
Published: March 2024

This paper presents the preliminary results of an investigation on the unexplored topic of polychromy on provincial stone sculptures from the Roman provinces in Germania through the innovative application of heritage materials science techniques. A group of three life-sized statues dating to the 1st Century CE recovered from Ingelheim, near Mainz, retains remarkably well-preserved traces of pigments. These are ripe for emerging non-invasive technologies supplemented by micro-sampling to validate results and provide information relating to mixing and layering not available to the naked eye. The most strikingly visible areas of extant polychromy were retained on the sculpture of a young woman, reported on here as the first phase of this programme of research. The results suggest that the statue was originally covered in a gypsum layer before the application of complex and diverse recipes of pigment applied as mixtures and in layers to create required hues and shadowing on sculpted features. The palette includes ochres and green earth mixed with small amounts of minium (red lead), realgar and lapis lazuli (ultramarine blue) added to create skin tones, and a vibrant blue-green tunic created from Egyptian blue, bone black, ochres, cinnabar and green earth; the palla and peplos contained ochres, bone black, and orpiment, and mixes of these created the detail of coloured jewellery. Of great interest was the detection of bone black on many features, particularly as a shading agent to enhance sculpted features, such as folds in cloth, providing a more realistic and flowing articulation. This is a revolutionary observation that provides previously unexplored insights into artistic polychromic practice in Antiquity.
LbHSP17.9 Participated in the Regulation of Cold Stress in Cut Lily Flowers
Authors: Zhao Jiahui , Yan Xinyu , Huang Wei , Liu Cheng , Hao Xuan , Gao Chengye , Deng Minghua , Wen Jinfen
Published: March 2024

Heat shock proteins (HSPs) play important roles in plant stress resistance, but it is not clear whether small molecular HSPs (sHSPs) are involved in the cold stress resistance of lily flowers. In this study, we cloned LbHSP17.9 and found that its expression was up-regulated under cold stress. When LbHSP17.9 was silenced (TRV2::LbHSP17.9) using virus-induced gene silencing in cut lily flowers, the content of malondialdehyde was increased under 4 °C stress treatment. The catalase (CAT) activity in TRV2::LbHSP17.9 was significantly lower than in TRV2 in the first 7 days, and the peroxidase (POD) activity in TRV2::LbHSP17.9 was significantly lower than in TRV2 after 4 days of 4 °C stress. Further analysis showed that the transcription levels of LbCu/ZnSOD, LbMnSOD and LbCAT in TRV2::LbHSP17.9 were lower than those of TRV2 under 4 °C stress. When LbHSP17.9 was overexpressed in lily petal disks, the OE-LbHSP17.9 disks faded later than the controls at 4 °C and the relative conductivity decreased significantly. Overexpression of LbHSP17.9 in Arabidopsis thaliana resulted in fewer injury symptoms and lower MDA content than wild type under 4 °C stress. Therefore, we speculate that LbHSP17.9 can improve the resistance of lily flowers to cold stress.
Mechanical Performance of Patched Pavements with Different Patching Shapes Based on 2D and 3D Finite Element Simulations
Authors: Wang Shujian , Zhang Han , Du Cong , Wang Zijian , Tian Yuan , Yao Xinpeng
Published: March 2024

Patching is a common technology used in repairing asphalt-pavement potholes. Due to the differences in material properties between patched- and unpatched-asphalt mixtures, significant strain and stress concentrations could be induced; thus, further cracks and interfacial debonding distress could be caused. As a remedy, the strain and stress concentrations can be alleviated by utilizing optimum patching shapes. Therefore, this paper employed finite element methods (FEM) to deeply analyze the mechanical performance of patched-asphalt pavements embedded with different patching shapes. Three patching shapes, these being rectangular, stair, and trapezoid, were considered for use in pavement pothole repairs based on two- and three-dimensional finite element models. In the two-dimensional models, Top-Down and Bottom-Up crack propagations were simulated to assess the anti-damage performance of the patched pavements with different patching shapes. In addition, the thermal stress behaviors within patched-asphalt pavements were simulated using the two-dimensional model to analyze the performance of the patched pavements during the cooling process in construction. In addition, interface-debonding performance was simulated for the patched-asphalt pavements using three-dimensional models. In light of the simulation results, engineers are expected to better understand the mechanism within patched pavements and to improve the quality of the pavement patching.
Geographical Characteristics of Culex tritaeniorhynchus and Culex orientalis Microbiomes in Korea
Authors: Lee Jeong-Hyeon , Lee Hee-Il , Kwon Hyung-Wook
Published: March 2024

Mosquitoes, the primary vectors of arboviruses, harbor a diverse microbiome that plays a crucial role in their development, immunity, and vector competence. The composition of the mosquito microbiome is heavily influenced by the environment and habitats. Therefore, identifying the relationship between the habitat and the mosquito’s microbial community can improve the overall understanding of mosquito biology. However, The microbiome profiles of Culex tritaeniorhynchus and Culex orientalis, known as transmission vectors of the Japanese encephalitis virus, are poorly understood. Using 16S rRNA Illumina sequencing, we hereby investigated the microbial profiles in these two mosquito species collected in several areas in the Republic of Korea. Thirty-six prevalent bacterial families were identified from these mosquito species. The microbial composition variations were primarily influenced by the mosquito collecting sites. Moreover, species biomarkers were identified by utilizing the regional specificity of the mosquito microbiome. Based on the microbiome profiles representing high similarity, Culex orientalis may share an ecological niche with Culex tritaeniorhynchus.
Mamestra brassicae Multiple Nucleopolyhedroviruses Prevents Pupation of Helicoverpa armigera by Regulating Juvenile Hormone Titer
Authors: Yang Yanqing , Dai Jinping , Zhang Guozhi , Singh Deepali , Zhang Xiaoxia , Liang Zhenpu
Published: March 2024

Baculovirus infection can prevent the pupation of insects. Juvenile hormone (JH) plays a vital role in regulating insect molting and metamorphosis. However, the molecular mechanism of baculovirus preventing the pupation of larvae by regulating the Juvenile hormone (JH) pathway is still unclear. In this study, we found that the Mamestra brassicae multiple nucleopolyhedroviruses (MbMNPV) infection prolonged the larval stage of fourth instar Helicoverpa armigera (H. armigera) by 0.52 d and caused an increase in JH titer. To identify the genes that contribute to the JH increase in H. armigera-MbMNPV interaction, we analyzed mRNA expression profiles of the fat bodies of H. armigera infected by MbMNPV. A total of 3637 differentially expressed mRNAs (DE-mRNAs) were filtered out through RNA-seq analysis. These DE-mRNAs were mainly enriched in Spliceosome, Ribosome biogenesis in eukaryotes, Aminoacyl-tRNA biosynthesis, Mismatch repair, and RNA degradation signaling pathway, which are related to the virus infection. Real-time PCR was used to verify the RNA sequencing results. To find out which genes caused the increase in JH titer, we analyzed all the DE-mRNAs in the transcriptome and found that the JHE and JHEH genes, which were related to JH degradation pathway, were down-regulated. JHE and JHEH genes in the larvae of MbMNPV-infected group were significantly down-regulated compared with the control group by RT-qPCR. We further proved that the JH is degraded by JHE in H. armigera larvae by RNAi, ELISA, RT-qPCR and bioassay, while the hydrolysis of JH by JHEH in H. armigera larvae can almost be ignored. Knocking down of HaJHE promoted the expression of the JH receptor gene Met and the downstream gene Kr-h1, and the replication of MbMNPV. This study clarified that JH is mainly degraded by JHE in H. armigera larvae. The MbMNPV infection of H. armigera larvae leads to the increase of JH titer by inhibiting the expression of JHE. The increase in JH titer promotes the expression of the JH receptor gene Met and the downstream gene Kr-h1, which prevents the pupation of H. armigera, and promotes MbMNPV replication. This study provides new insights into H. armigera and MbMNPV interaction mechanisms.
Miyalachnus—A New Lachninae Aphid Genus from Japan (Insecta, Hemiptera, Aphididae)
Authors: Kanturski Mariusz , Lee Yerim
Published: March 2024

The tribe Tuberolachnini within the Lachninae (Hemiptera: Aphididae) is particularly intriguing due to its morphological traits and various ecological associations. Among the genera within this group, Pyrolachnus stands out as relatively understudied. Currently, only one species, Pyrolachnus imbricatus nipponicus Sorin, 2011, is known from Japan, distinguished by its distinctive characteristics. Through meticulous morphological analyses, we introduce a novel Lachninae genus, Miyalachnus gen. nov., associated with Cerasus and Prunus spp. (Rosaceae) in Japan. This new genus accommodates P. imbricatus nipponicus, now recognized as Miyalachnus nipponicus (Sorin, 2011) comb. nov. Additionally, we present a second species within this genus, Miyalachnus sorini sp. nov., along with comprehensive SEM morphological examination and insights into its biology. Our study describes in detail the morphological characteristics of both viviparous and bisexual generations of Miyalachnus, as well as their relationships with related genera.
Integration of Smart Cane with Social Media: Design of a New Step Counter Algorithm for Cane
Authors: Messaoudi Mohamed Dhiaeddine , Menelas Bob-Antoine J. , Mcheick Hamid
Published: March 2024

This research introduces an innovative smart cane architecture designed to empower visually impaired individuals. Integrating advanced sensors and social media connectivity, the smart cane enhances accessibility and encourages physical activity. Three meticulously developed algorithms ensure accurate step counting, swing detection, and proximity measurement. The smart cane’s architecture comprises the platform, communications, sensors, calculation, and user interface layers, providing comprehensive assistance for visually impaired individuals. Hardware components include an audio–tactile interaction module, input command module, microphone integration, local storage, step count module, cloud integration, and rechargeable battery. Software v1.9.7 components include Facebook Chat API integration, Python Facebook API integration, fbchat library integration, and Speech Recognition library integration. Overall, the proposed smart cane offers a comprehensive solution to enhance mobility, accessibility, and social engagement for visually impaired individuals. This study represents a significant stride toward a more inclusive society, leveraging technology to create meaningful impact in the lives of those with visual impairments. By fostering socialization and independence, our smart cane not only improves mobility but also enhances the overall well-being of the visually impaired community.
Revealing the Unseen: Detecting Negative Symptoms in Students
Authors: Métivier Lucie , Mauduy Maxime , Beaunieux Hélène , Dollfus Sonia
Published: March 2024

Background: The transnosographic nature of negative symptoms (NS) makes them fruitful for detecting psychiatric symptoms. The main objective of this study was to determine whether NS can be useful in screening for ultra-high risk of psychosis (UHR) or depressive symptoms in the no-help-seeking student population. The most prevalent NS and their relationship with cannabis use were also researched. Methods: From an online survey sent to students, 2128 filled out the Self-evaluation of Negative Symptoms (SNS), Prodromal Questionnaire 16 (PQ-16), Beck Depression Inventory (BDI), and Cannabis Abuse Screening Test (CAST). Results: 367 students (17.2%, 95% CI [15.6–18.9]) were considered to have UHR (PQ-16 distress score ≥ 9) and/or depression (BDI ≥ 16). The receiver operation characteristic curve showed that a threshold of 13 for the SNS score discriminated this subgroup of students with a sensitivity and specificity of 79.8% and 70.6%, respectively. The motivational dimension was overrepresented and linked to cannabis use. Conclusions: The early detection of NS in the no-help-seeking student population is relevant for detecting depressive and prodromal symptoms. This will enable early intervention to limit the progression to chronic mental disorders. The predominance of NS linked to the amotivational dimension was observed and related to cannabis use.
Parenteral Anticoagulation at First Medical Contact Improves Infarct Related Artery Patency in STEMI
Authors: Bataila Vlad , Popa-Fotea Nicoleta-Monica , Cojocaru Cosmin , Calmac Lucian , Mihai Cosmin , Dragoescu Marian-Bogdan , Ploscaru Vlad , Marinescu Mugur , Iliese Vasile , Avram Anamaria-Georgiana , Mitran Raluca-Elena , Vatasescu Radu-Gabriel
Published: March 2024

(1) Background: Acute ST-segment elevation myocardial infarction (STEMI) remains one of the main morbidity and mortality contributors worldwide. Its main treatment, primary percutaneous coronary intervention (pPCI), can only be performed with a high anticoagulation regimen, usually with heparin. There is still not enough evidence regarding the timing of heparin administration. (2) Methods: We conducted a multicenter observational study of 614 consecutive STEMI patients treated between 2017 and 2019. We split the population in two groups: one that received heparin at the first medical contact, as early as possible, and the second group that received heparin at the PCI capable center or in the cath lab. (3) Results: There was a significantly higher rate of infarct-related artery (IRA) patency at the time of the coronary angiogram in the pre-transfer heparin group than in the on-site heparin group, 44.7% vs. 37.3%, p = 0.042. Also, the early heparin group received shorter and wider stents. There was no difference in bleeding rates or in the in-hospital and two-year mortality rates. (4) Conclusions: Early administration of heparin leads to a higher rate of reperfusion in the IRA, before pPCI, with significant related benefits, such as better stent implantation parameters, without increased bleeding rates.
Early Breast Cancer: Could Combined LOCalizerTM and Ultrasound Localization Replace the Metallic Wire? A Multicentric Study
Authors: Parisi Simona , Gambardella Claudio , Santoriello Antonio , Ruggiero Roberto , Iovino Francesco , Fisone Francesca , Mongardini Federico Maria , Lucido Francesco Saverio , Tolone Salvatore , Docimo Ludovico
Published: March 2024

Background: Breast localization plays a key role in early breast cancer (BC) surgery. The current gold standard is wire-guided localization (WGL), despite the known disadvantages. The patients often experience anxiety and discomfort due the metallic wire placed in the breast, and surgeons are compelled to perform the surgery on the same day as the radiological release of the wire to prevent migrations or breakages. Various wireless systems have been proposed as alternative to WGL. LOCalizerTM offers the advantage of providing the exact distance from the marker called Tag. The combined technique using LOCalizerTM and US allows for determining the distance from the BC margin, a critical surgical goal for oncological radicality. Methods: Patients referred for breast surgery to two Italian hospitals were enrolled and divided into two groups: Group A, including patients undergoing a combined approach, and group B, including patients treated with conventional WGL. Results: The combined approach with LOCalizerTM and US was associated with better outcomes in terms of oncological radicality, cosmetic results, and patients’ satisfaction. Conclusions: In the current study, LOCalizerTM associated with US could be considered an excellent approach for localizing non-palpable BC. Further larger comparative studies are needed to address this issue.
Fresh Frozen Homologous Rib Cartilage: A Narrative Review of a New Trend in Rhinoplasty
Authors: Salzano Giovanni , Audino Giovanni , Dell’Aversana Orabona Giovanni , Committeri Umberto , Troise Stefania , Arena Antonio , Vaira Luigi Angelo , De Luca Pietro , Scarpa Alfonso , Elefante Andrea , Romano Antonio , Califano Luigi , Piombino Pasquale
Published: March 2024

Background: Revision rhinoplasty is a technically demanding surgical procedure that can put every surgeon in trouble. The main issue of these cases is often an altered osteocartilaginous framework following over-resection during the first intervention. Moreover, the available septal or auricular cartilage for grafting is usually not enough. This review aims to examine contemporary advances in applications of fresh frozen cartilage in rhinoplasty. Methods: A structured review of the current literature (up to December 2023) was performed on four bibliographic databases: PubMed, EMBASE, Cochrane and Medline. The search terms were combinations of “Rhinoplasty” and “Cartilage Graft”, “Allograft” or “Fresh Frozen Cartilage”. The citations of selected studies and review articles were also evaluated if present. Results: The research resulted in 152 articles, and only ten met the inclusion criteria: nine clinical articles and one in vitro study. One of the ten eligible articles was excluded. Conclusions: Fresh frozen rib cartilage proved to be a viable alternative to autologous rib grafts and irradiated homologous rib graft. Despite the higher costs, FFRG can provide a sufficient amount of tissue for grafting avoiding donor site complications and reducing the operative time and proved to have more chondrocytes and to be less prone to resorption compared to irradiated rib.
May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study
Authors: Facciorusso Salvatore , Spina Stefania , Picelli Alessandro , Baricich Alessio , Molteni Franco , Santamato Andrea
Published: March 2024

Background/Objectives: This study examined the impact of spasticity-related unpleasant sensations (pain, heaviness, stiffness) on various domains of the International Classification of Functioning, Disability, and Health (ICF) and psychosocial well-being in individuals affected by stroke or traumatic brain injury (TBI). The primary aim is to explore how these sensations affect daily activities, participation, and overall quality of life, guided by the comprehensive framework of the ICF. Methods: Utilizing a secondary analysis of data from a cohort undergoing Botulinum toxin type-A treatment for spasticity post-stroke or TBI, we developed and administered an ad-hoc questionnaire focusing on ICF domains such as body function, activities and participation, and psychosocial aspects such as mood, relationship, social life, motivation, and sleep quality. Spearman rho correlation was applied to assess the relationship between unpleasant sensations and functional as well as psychosocial outcomes among 151 participants. Results: This study identified significant correlations between the severity of unpleasant sensations and limitations in daily functioning, particularly in activities of daily living and mobility. Furthermore, an impactful association was identified between increased unpleasant sensations and deterioration in psychosocial well-being, notably in mood and sleep quality. Conclusions: These findings advocate for a person-centered approach in spasticity management, emphasizing the integration of sensory impairment strategies into rehabilitation to enhance functional outcomes and quality of life. Such an approach aims to improve functional outcomes and enhance the quality of life for individuals experiencing spasticity post-stroke or TBI. Future directions include targeted interventions to alleviate these sensations, support better rehabilitation results and improve patient experiences.
Proof of Concept of Telemedicine-Assisted Abdominal Ultrasound Examinations to Improve the Quality of Patient Care in Rural Areas
Authors: Kleemann Tobias , Müller Denise , Güther Carola , Duma Alina , Mohamed Awsan , Ernst Helmut , Löbel Madlen , Freund Robert , Kleemann Sven , Pannach Sven , Stellke Rutker , Briesemann Dirk , Diepelt Tina , Thomas Ina , Ermisch Viktoria , Aretakis Dimitrios , Wree Alexander , Tacke Frank , Ortmann Steffen , Schulz Marten
Published: March 2024

(1) Background: Unclear sonographic findings without adequate specialist expertise in abdominal ultrasound (AU) may harm patients in rural areas, due to overlooked diagnoses, unnecessary additional imaging (e.g., CT scan), and/or patient transport to referral expert centers. Appropriate telemedical sonography assistance could lead to corresponding savings. (2) Methods: The study was designed as a randomized trial. Selected study centers performed AU with the best local expertise. Patients were selected and monitored according to the indication that they required AU. The study depicted three basic scenarios. Group 1 corresponds to the telemedically assisted cohort, group 2 corresponds to the non-telemedically assisted cohort, and group 3 corresponds to a telemedically supported cohort for teaching purposes. The target case number of all three groups was 400 patients (20 calculated dropouts included). (3) Discussion: This study might help to clarify whether telemedicine-assisted ultrasound by a qualified expert is non-inferior to presence sonography concerning technical success and whether one of the interventions is superior in terms of efficacy and safety in one or more secondary endpoints. Randomization was provided, as every patient who needed an AU was included and then randomized to one of the groups. The third group consisted of a lower number of patients who were selected from group 1 or 2 for teaching purposes in case of rare diseases or findings. (4) Conclusions: The study investigates whether there are benefits of telemedical ultrasound for patients, medical staff, and the health care system.
Mitochondrial Metabolism in Major Depressive Disorder: From Early Diagnosis to Emerging Treatment Options
Authors: Larrea Ane , Sánchez-Sánchez Laura , Diez-Martin Eguzkiñe , Elexpe Ane , Torrecilla María , Astigarraga Egoitz , Barreda-Gómez Gabriel
Published: March 2024

Major Depressive Disorder (MDD) is one of the most disabling diseases in the world. MDD is traditionally diagnosed based on a patient’s symptoms, which can lead to misdiagnosis. Although the pathogenic mechanisms of MDD are unknown, several studies have identified mitochondrial dysfunction as a central factor in the onset and progression of MDD. In the context of MDD, alterations in mitochondrial metabolism can lead to imbalances in energy production and oxidative stress, contributing to the disorder´s underlying pathophysiological mechanisms. Consequently, the identification of mitochondrial dysfunction as a key biomarker for early and accurate diagnosis of MDD represents a significant challenge. Faced with the limits of traditional treatments with antidepressants, new pharmacological therapeutic targets are being investigated such as ketamine/esketamine, psychedelics, or anti-inflammatories. All of these drugs show potential antidepressant effects due to their speed of action and ability to modulate neuroplasticity and/or motor processing. In parallel, non-pharmacological therapeutic targets are studied, like Transcranial Magnetic Stimulation (TMS) and Deep Brain Stimulation (DBS), recognized for their ability to modulate neuronal activity and offer treatment alternatives. As cellular activity is directly related to mitochondrial respiration, the aim of this review is examining the link between mitochondrial dysfunction and MDD, assessing how mitochondrial biomarkers could provide a more objective and precise diagnostic tool, and exploring other treatments in addition to traditional antidepressants, with a specific focus on emerging therapeutic targets. Finally, a detailed analysis of the strengths, weaknesses, opportunities, and threats of these approaches was carried out, highlighting the key challenges that must be addressed.
Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects
Authors: Grosu-Bularda Andreea , Hodea Florin-Vlad , Cretu Andrei , Lita Flavia-Francesca , Bordeanu-Diaconescu Eliza-Maria , Vancea Cristian-Vladimir , Lascar Ioan , Popescu Serban Arghir
Published: March 2024

The field of plastic surgery is continuously evolving, with faster-emerging technologies and therapeutic approaches, leading to the necessity of establishing novel protocols and solving models. Surgical decision-making in reconstructive surgery is significantly impacted by various factors, including the etiopathology of the defect, the need to restore form and function, the patient’s characteristics, compliance and expectations, and the surgeon’s expertise. A broad surgical armamentarium is currently available, comprising well-established surgical procedures, as well as emerging techniques and technologies. Reconstructive surgery paradigms guide therapeutic strategies in order to reduce morbidity, mortality and risks while maximizing safety, patient satisfaction and properly restoring form and function. The paradigms provide researchers with formulation and solving models for each unique problem, assembling complex entities composed of theoretical, practical, methodological and instrumental elements.
Importance of Short-Term Neointimal Coverage of Drug-Eluting Stents in the Duration of Dual Antiplatelet Therapy
Authors: Fluder-Wlodarczyk Joanna , Pawłowski Sławomir , Chuchra Piotr J. , Pawłowski Tomasz , Wojakowski Wojciech , Gasior Pawel
Published: March 2024

Dual antiplatelet therapy (DAPT) is mandatory after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation, but optimal DAPT duration remains a topic of intense discussion. The shorter regimen of DAPT might be especially beneficial for high-bleeding-risk (HBR) patients. Novel stent platforms have been designed with innovations that should facilitate vessel healing following stent implantation and enable short DAPT. This review aimed to summarize evidence of the neointimal coverage of short-term stents and their implications for DAPT duration. Results from histological and optical coherence tomography (OCT) studies confirm the significant role of uncovered struts after the implantation of a stent in patients presenting with late stent thrombosis. Several studies have shown favorable vessel healing at one month (with 83.2% of covered struts, on average) and three months following stent implantation (with 93.3% of covered struts, on average). Solely HBR patient trials have proven that one month of DAPT can be applicable and safe in this population. Three-month DAPT was tested in a more diverse population and remains effective and safe in comparison to a longer DAPT regimen. That evidence proves that short-term DAPT might be applicable, especially for HBR patients.
Hallux Valgus Plantar Pressure Distribution before and after a Distal Metatarsal Osteotomy
Authors: Mazzotti Antonio , Arceri Alberto , Artioli Elena , Langone Laura , Zielli Simone Ottavio , Martini Beatrice , Traina Francesco , Faldini Cesare , Brognara Lorenzo
Published: March 2024

Background: Hallux valgus (HV) morphological alterations impact forefoot kinetics. Surgery aims to restore both the morphology and function. Plantar pressure (PP) distribution systems represent an innovative additional tool to evaluate the hallux functional outcome after surgery in order to assess the hallux dorsiflexion, coupled with plantar flexion of the first ray. However, the literature reports limited evidence regarding the rebalancing of the plantar pressure distribution following surgery. The purpose of the present study was to examine the PP distribution in HV patients before and after a distal metatarsal osteotomy using a novel anatomically based protocol for in-shoe plantar load analysis during gait. Methods: A consecutive series of 18 patients with mild-to-moderate symptomatic HV who underwent a distal metatarsal osteotomy (S.E.R.I. technique) were prospectively evaluated using clinical scores (AOFAS and NRS), radiographic parameters (hallux valgus angle, intermetatarsal angle), and PP measurements via W-INSHOE© (Medicapteurs, Balma, France). Data were collected preoperatively and 12 months after surgery. Results: At 12 months follow-up, 3 patients were lost to follow-up, leaving 15 patients (24 HV) for examination. Both clinical and radiographical outcomes showed significant improvements from the pre- to postoperative periods. The PP distribution pattern revealed a significant increase in the peak pressure under the first metatarsal head associated with a significant increase in the peak pressure under the central metatarsals area between the pre- and postoperative periods. Conclusions: PP measurement systems hold promise as an additional clinical tool, yet current findings remain inconclusive. Further long-term follow-up studies that incorporate additional parameters are warranted.
Waist Circumference and Body Mass Index as Predictors of Disability Progression in Multiple Sclerosis: A Systematic Review and Meta-Analysis
Authors: Giannopapas Vasileios , Stefanou Maria-Ioanna , Smyrni Vassiliki , Kitsos Dimitrios K. , Kosmidou Maria , Stasi Sophia , Chasiotis Athanasios K. , Stavrogianni Konstantina , Papagiannopoulou Georgia , Tzartos John S. , Paraskevas George P. , Tsivgoulis Georgios , Giannopoulos Sotirios
Published: March 2024

Background: While obesity has been shown to elevate the risk of developing multiple sclerosis (MS), there is a lack of strong evidence regarding its role in the disability progression and status of MS patients. Methods: This systematic review and meta-analysis aimed to provide comparative estimates of WC and BMI in patients with MS (PwMS) and to investigate potential associations between the waist circumference (WC) and body mass index (BMI) and demographic and specific MS characteristics. Adhering to PRISMA guidelines, a detailed search of the MEDLINE PubMed, Cochrane Library, and Scopus databases was conducted. Results: A total of 16 studies were included. The pooled mean WC and BMI among PwMS was estimated to be 87.27 cm (95%CI [84.07; 90.47]) and 25.73 (95%CI [25.15; 26.31]), respectively. Meta-regression models established a significant bidirectional relationship between WC and the Expanded Disability Scale (EDSS) (p < 0.001) but not between BMI and EDSS (p = 0.45). Sensitivity analyses showed no association between WC and age (p = 0.48) and a tendency between WC and disease duration (p = 0.08). Conclusions: Although WC measurements classify PwMS as normal weight, BMI measurements classify them as overweight. Therefore, WC should complement BMI evaluations in clinical practice. Additionally, our findings highlight the significant association between abdominal fat, as indicated by WC, and disease progression. Considering the heightened risk of cardiovascular comorbidity and mortality among PwMS, we recommend integrating both WC and BMI as standard anthropometric measurements in routine clinical examinations and targeted prevention strategies for PwMS.
Reports of Gastric Banding and Bowel Obstruction: A Narrative Review of the Literature
Authors: Vitiello Antonio , Matarese Alessandro , Sansone Giulia , Cappiello Emanuela , Berardi Giovanna , Calabrese Pietro , Peltrini Roberto , Pilone Vincenzo
Published: March 2024

The utilization rates of laparoscopic gastric banding (LAGB) declined worldwide from 42.3% in 2008 to 1.8% in 2018. Rates of complications requiring removal may reach 40–50% in the medium to long term. Bowel obstruction is a rare but severe complication that occurs after LAGB. A comprehensive literature search in PubMed was carried out to identify all available case reports of intestinal obstruction after gastric banding. The search terms were as follows: “intestinal obstruction”, “small bowel obstruction”, “gastric band”, “gastric banding”, “gastric band complications”, and “laparoscopic gastric band obstruction”. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) flowchart was used. Forty-three case reports were included in our review. Laparotomy was necessary in 18/43 (41%) of patients. Vomit was not always reported, while abdominal pain was constantly present. A CT scan was the preferred diagnostic tool. The main causes of occlusion were found to be the erosion of the gastrointestinal tract or internal hernia due to a loose tube loop. Forty-six percent of cases occurred within 5 years from insertion. Even if rare, small bowel obstruction after LAGB requires surgical intervention often with an open approach. The absence of vomit masks symptoms, but an obstruction must be always suspected in the case of severe colicky abdominal pain. A CT scan is recommended for making diagnoses.
Risk of Diabetic Ketoacidosis Associated with Sodium Glucose Cotransporter-2 Inhibitors: A Network Meta-Analysis and Meta-Regression
Authors: Sridharan Kannan , Sivaramakrishnan Gowri
Published: March 2024

Background: Sodium glucose cotransporter-2 inhibitors (SGLT2is) represent an emerging class of drugs with diverse indications. Despite their therapeutic potential, concerns regarding safety, particularly diabetic ketoacidosis (DKA), remain contentious, with uncertainty regarding differences among various SGLT2is. This study aimed to conduct a network meta-analysis and meta-regression to evaluate the risk of SGLT2i-induced DKA and associated factors. Methods: We systematically searched electronic databases for randomized clinical trials assessing SGLT2is across indications, reporting incidences of DKA. Mixed treatment comparison pooled estimates (MTCPEs) were calculated, and odds ratios (OR) with 95% confidence intervals (95% CI) served as effect estimates. We analyzed differences across dose categories (low, medium, and high) and conducted a meta-regression analysis to identify risk factors. The strength of evidence for key comparisons was determined. Results: Our analysis included 73 articles encompassing 85,997 participants assessing the risk of DKA. SGLT2is were associated with a heightened risk of DKA compared to placebo/control interventions (OR: 1.83; 95% CI: 1.35, 2.46), a finding confirmed by bootstrap analysis. Among SGLT2is, dapagliflozin (OR: 1.9; 95% CI: 1.17, 3.08), sotagliflozin (OR: 1.93; 95% CI: 1.14, 3.25), canagliflozin (OR: 1.11; 95% CI: 1.11, 12.45), and ertugliflozin (OR: 3.92; 95% CI: 1.04, 14.77) exhibited increased DKA risk. No significant differences were observed among specific SGLT2is. Sub-group analyses revealed a high risk of DKA with low (OR: 1.98; 95% CI: 1.3, 2.95) and high doses (OR: 2.4; 95% CI: 1.7, 3.3), type 1 diabetes (OR: 3.6; 95% CI: 1.6, 8.1), type 2 diabetes (OR: 1.6; 95% CI: 1.3, 2.4), as well as a diabetes duration exceeding 10 years (OR: 3.4; 95% CI: 1.1, 10.8). The evidence of certainty for most comparisons was moderate. Conclusions: SGLT2 inhibitors (SGLT2is) have been found to elevate the risk of DKA. The key factors that significantly predict the likelihood of DKA include the presence of diabetes (whether T1D or T2D) and the duration of diabetes. Based on these findings, standard treatment guidelines should advise taking specific precautions against DKA in patients identified as high-risk.
Clinical Utility of Genetic Testing with Geographical Locations in ADPKD: Describing New Variants
Authors: García Rabaneda Carmen , Bellido Díaz María Luz , Morales García Ana Isabel , Poyatos Andújar Antonio Miguel , Bravo Soto Juan , Dayaldasani Khialani Anita , Martínez Atienza Margarita , Esteban de la Rosa Rafael Jose
Published: March 2024

Background: Our study aims to comment on all ADPKD variants identified in our health area and explain how they are distributed geographically, to identify new variants, and relate the more frequent variants with their renal phenotype in terms of kidney survival. Materials and Methods: We identified patients suffering from ADPKD in a specialized consultation unit; genealogical trees were constructed from the proband. According to the ultrasound-defined modified Ravine–Pei criteria, relatives classified as at risk were offered participation in the genetic study. Socio-demographic, clinical, and genetic factors related to the impact of the variant on the survival of the kidney and the patient, such as age at RRT beginning and age of death, were recorded. Results: In 37 families, 33 new variants of the PKD1 gene were identified, which probably produce a truncated protein. These variants included 2 large deletions, 19 frameshifts, and 12 stop-codons, all of which had not been previously described in the databases. In 10 families, six new probably pathogenic variants in the PKD2 gene were identified. These included three substitutions; two deletions, one of which was intronic and not associated with any family; and one duplication. A total of 11 missense variants in the PKD1 gene were grouped in 14 families and classified as probably pathogenic. We found that 33 VUS were grouped into 18 families and were not described in the databases, while another 15 were without grouping, and there was only 1 in the PKD2 gene. Some of these variants were present in patients with a different pathogenic variant (described or not), and the variant was probably benign. Renal survival curves were compared to nonsense versus missense variants on the PKD1 gene to check if there were any differences. A group of 328 patients with a nonsense variant was compared with a group of 264 with a missense variant; mean renal survival for truncated variants was lower (53.1 ± 0.46 years versus non-truncated variant 59.1 ± 1.36 years; Log Rank, Breslow, and Tarone Ware, p < 0.05). Conclusions: To learn more about ADPKD, it is necessary to understand genetics. By describing new genetic variants, we are approaching creation of an accurate genetic map of the disease in our country, which could have prognostic and therapeutic implications in the future.
Assessment of the Relationship between Periodontitis and Cardiac Parameters in Patients with Early Chronic Heart Failure: A Cross-Sectional Study
Authors: Schulze Antina , Kwast Stefan , Pökel Christoph , Busse Martin
Published: March 2024

Periodontal disease (PD) is considered a risk factor for cardiovascular events. However, its relationship to chronic heart failure (CHF) is unclear. The aim was to compare cardiac and inflammatory parameters in CHF patients with (PG) versus without periodontitis (NPG). The following parameters were recorded in 58 patients: periodontal screening and recording (PSR), troponin T, NT-proBNP, C-reactive protein (CRP), interleukin-6 (IL-6), blood pressure, heart rate, ejection fraction (EF), ventricular systolic and diastolic function parameters, incremental test, and three questionnaires (Mediterranean Diet Adherence Screener, MEDAS; Oral Health Impact Profile, OHIP-14; Patient Health Questionnaire, PHQ). The serum levels of NT-proBNP and troponin T were significantly higher in the PG, and the left ventricular systolic and diastolic function parameters were significantly lower. The correlation analysis showed age as the only independent risk factor for periodontitis and cardiac biomarkers. No significant group differences were found in the MEDAS, OHIP-14, and PHQ scores, or in CRP, IL-6, and cardiocirculatory parameters. Overall, the BMI correlated significantly with the mean PSR and total cholesterol. The occurrence of increased PSR together with increased age and cardiac risk parameters does not exclude an association between periodontitis and CHF, though no positive correlation was calculated. Periodontitis may be a modifiable risk factor for CHF. Its treatment may help to control the inflammatory burden.
Experimental Study on the Effect of Wind on Armor Stone Stability
Authors: Kim Young-Min , Lim Jae-Ho , Yoon Hyun-Doug
Published: March 2024

Wind is a significant factor influencing the stability of breakwater armor stones. However, few existing studies have considered the effects of wind on these structures. In this study, two-dimensional laboratory experiments were conducted to examine the effect of wind on the stability of breakwater armor stones. The stability factor (KD) of the armor stone, fluid velocity, runup, and rundown were observed under the action of waves and winds. A wind turbine was installed in front of the physical model of the breakwater to generate extreme wind conditions of 5.5 and 12 m/s. The results showed that KD decreased by 42.18% at 5.5 m/s and 57.82% at 12 m/s compared with that without wind. The maximum runup and rundown heights increased with wind velocity, following a Rayleigh distribution. The fluid velocity distribution conformed to a normal distribution, with the mean velocity directed offshore. Many studies have suggested that runup, rundown, and fluid velocity are the main factors affecting the stability of breakwater armor stones. The analysis revealed that wind affects these factors and lowers the stability coefficient. These wind-induced hydrodynamic changes suggest the need for a detailed hydrodynamic review of wind-wave conditions.
Laboratory Investigations of Iceberg Melting under Wave Conditions in Sea Water
Authors: Marchenko Aleksey , Marchenko Nataliya
Published: March 2024

Changes in the masses of icebergs due to deterioration processes affect the drift of icebergs and should be taken into account when assessing iceberg risks in the areas of offshore development. In 2022 and 2023, eight laboratory experiments were carried out in the wave tank of the University Centre in Svalbard to study the melting of icebergs in sea water under calm and rough conditions. In the experiments, the water temperatures varied from 0 ℃ to 2.2 ℃. Cylindrical iceberg models were made from columnar ice cores with a diameter of 24 cm. In one experiment, the iceberg model was protected on the sides with plastic fencing to investigate the iceberg’s protection from melting when towed to deliver fresh water. The iceberg masses, water temperatures, and ice temperatures were measured in the experiments. The water velocity near the iceberg models was measured with an acoustic Doppler velocimeter. During the experiments, time-lapse cameras were used to describe the shapes and measure the vertical dimensions of the icebergs. Using experimental data, we calculated the horizontal dimensions of icebergs, latent heat fluxes, conductive heat fluxes inside the iceberg models, and turbulent heat fluxes in water as a function of time. We discovered the influence of surface waves and water mixing on the melt rates and found a significant reduction in the melt rates due to the lateral protection of the iceberg model using a plastic barrier. Based on the experimental data obtained, the ratio of the rates of lateral and bottom melting of the icebergs and lateral melting of the icebergs under wave conditions was parametrized depending on the wave frequency.
Critical Discourse Analysis on Parental Language Ideologies of Bilingual and Multilingual Child-Rearing and Language Education Using Facebook and Internet Forums
Authors: Qian Yeshan
Published: March 2024

This study examines the computer-mediated discussion topics of parents who raise bilingual and multilingual children in four active Facebook and Internet forums, and investigates how the language ideologies embedded in the multiple languages being used in these forums are expressed. In this study, 179 data points, including users’ posts and thread comments, were collected to identify the most frequently discussed topics as part of my description of the database, in order to identify parental ideologies by using values analysis. The five most-discussed topics were selected to make a critical discourse analysis on the narratives to understand the language ideologies regarding the use of multiple languages, and regarding what users of the groups are saying specifically about the languages when analyzing metalinguistic discourses. This study found the most recurrent language ideologies that parents expressed on these online forums were supporting bilingualism/multilingualism, and claim that bilingualism/multilingualism is advantageous. Parents also demonstrate language ideologies supporting keeping languages separate, such as following the one parent one language (OPOL) method, using the minority language at home, and so on. A detailed values analysis with illustrative sample messages from the online posts and comments also more specifically shows the recurrent language ideologies identified, and parents’ views underlying their narratives on their posts and thread comments.
Gold Smuggling in India and Its Effect on the Bullion Industry
Authors: Susai Maria Immanuvel , Daniel Lazar
Published: March 2024

This study strives to examine when and where most of the gold smuggling takes place in India. It further analyses the causal relationship between smuggled gold and other macroeconomic variables. Finally, it analyses how the smuggled gold affects the Indian bullion industry. The data related to gold smuggling has been sourced from the website of the Directorate Revenue Intelligence and analysed using graphs and the Granger causality test. The variables used in the study are the quantity of smuggled gold, exchange rates, the major stock indices in the world, the number of auspicious days in a month, domestic and international gold prices, India’s jewellery export, the GDP, customs duty, and the domestic gold supply. The results revealed that most of the gold smuggling takes place on Fridays and mostly occurs in the months of October, November, and December. The states of West Bengal, Delhi, Maharashtra, and Tamil Nadu account for most of the gold smuggling in India. A positive correlation is observed between the smuggled gold, India’s gold demand, the number of auspicious days in the month, India’s jewellery export, India’s GDP, India’s domestic gold supply, and stock indices such as SENSEX, FTSE100, DFMGI. Gold smuggling in India is caused by India’s gold demand, the level of jewellery export, the GDP, domestic and international gold prices, and India’s customs duty.