bluuebunny/crossref_metadata_2025 huggingface dataset:
SINTESA MATERIAL BIOSCAFFOLD BERBAHAN DASAR PLA/NANOKITOSAN DENGAN PENAMBAHAN ZN-CURCUMIN
Authors: Aida Atiqah
Published: June 2021

Penelitian mengenai bioscaffold sebagai salah satu terobosan baru dalam bidang rekayasa jaringan sedang berkembang pesat untuk diteliti. Salah satu aplikasi bioscaffold dibidang rekayasa perancah jaringan tulang dapat memberikan solusi cepat untuk mendorong regenerasi jaringan tulang baru akibat kecelakaan kerja tulang serta cacat tulang. Material penyusun bioscaffold berupa sintesis maupun polimer alami. Polimer alami yang dapat digunakan ialah Poly Lactid Acid dikarenakan memiliki sifat yang sesuai dengan kriteria bioscaffold yakni biogradable, biokompatibel, tidak beracun dan aman bagi tubuh manusia. Namun sifat titik leleh PLA yang rendah dibandingkan polimer lainnya mengharuskan PLA dimodifikasi dengan bahan pengisi seperti Nanokitosan. Penggunaan Kitosan sebagai material bioscaffold telah dilakukan oleh Zuhra, 2017. Hasil yang didapatkan bahwa campuran dari kedua bahan tersebut bioscaffold yang kurang homogen berpengaruh terhadap kekuatan tarik bioscaffold.  Adapun novelty dari penelitian ini adalah meninjau karakteristik material bioscaffold berbahan dasar PLA/ Nanokitosan dengan penambahan Zn-Curcumin . Penambahan Zn-Curcumin memiliki potensi nanofiber komposit sebagai perancah jaringan tulang melalui seluler morfologi dan  MTT pengujian menunjukkan bahwa Zn-Cur yang mengandung nanofiber lebih baik mensupport adesi seluler, penyebaran dan proliferasi dibandingkan dengan nanofiber lainnya. Terlebih lagi ternyata penambahan Zn-Cur dapat meningkatkan aktivitas ALP dan produksi mineralisasi matriks Zn-CUR kompleks tidak hanya meningkatkan kinerja osteogenik tetapi juga memiliki aktivitas antibakteri yang baikKata kunci: Bioscaffold, PLA, Nanokitosan, Zn-Curcumin
PELET IKAN BERBASIS BIOMASSA KULIT KOPI, LIMBAH UDANG, DAUN KELOR DAN DEDAK PADI
Authors: . Ismail , Fona Zahra
Published: June 2021

Pelet ikan ini dibuat dengan mengkombinasikan limbah biomassa kulit kopi, limbah udang, daun kelor dan dedak padi. Tujuan penelitian ini adalah menentukan pengaruh komposisi tepung kulit kopi (fermentasi dan nonfermentasi), limbah udang, daun kelor dan dedak padi terhadap karakteristik proksimat dan daya apung pelet ikan. Pengujian kadar protein diakukan dengan menggunakan metode lowry, kadar lemak menggunakan alat ekstraksi, kadar abu menggunakan furnace dan kadar air dilakukan menggunakan oven. Masing-masing perlakuan dilakukan penambahan air 50 ml/100 g bahan. Adonan dibentuk menjadi pelet dengan ukuran 2 mm dan dikeringkan. Hasil pengujian kadar protein diperoleh hasil terbaik 1119,54 ppm, kadar air 6,07 %, kadar abu 4,05 % dan kadar lemak 5,85 % dengan daya apung selama 65 menit. Pelet ikan ini telah memenuhi standar SNI 01-7274-2006.Kata kunci— Pelet ikan, Biomassa, Fermentasi.
IMPLEMENTASI MANAJEMEN PENGEMBANGAN MUTU DOSEN PERGURUAN TINGGI AGAMA ISLAM NEGERI DI PROVINSI ACEH
Authors: Husaini Husaini , Barus Jumat
Published: June 2021

This study aims to analyze the implementation and evaluation of quality development of PTAIN lecturers in Aceh. A qualitative research method and descriptive approach is applied in the research. The research result shows that the implementation of quality development of PTAIN lecturers in Aceh is done by referring to the strategic plan or programs prepared at the beginning of the year. The forms of implementation of lecturer quality development include room visits, inspection to lecturers’ learning devices, and providing opportunities for lecturers to increase their competence and professionalism through various exercises and benchmarking to other leading Islamic universities. The evaluation for the lecturers quality development is carried out through routine meetings, weekly, mid semester, and annually at the beginning of academic year. The results of the evaluation will become supplementary materials for the institutions in following up the lecturers’ performance on the lecturers’ daily activities. The development carried out to the lecturers are in the form of admonition, providing training and development to increase the lecturers’ competence and professionalism, and also doing routine religious lectures.
THE INFLUENCE OF TRANSFORMATIONAL LEADERSHIP AND SELF-EFFICACY ON THE PERFORMANCE OF IAIN CURUP LECTURERS
Authors: Warlizasusi Jumira , Ifnaldi Ifnaldi
Published: June 2021

The objective of this study is to determine whether there is a direct or indirect effect of transformational leadership and self-efficacy on the performance of IAIN Curup lecturers. Based on pre-observation, the low frequency of lecturers' attendance which did not reach sixteen meetings, the difficulty to meet the Academic advisor for consultation, inappropriate expertise of lecturers, and some of the incompetent lecturers became the background leading the researchers to examine the performance of the IAIN Curup lecturers. In this study, there were three variables. A purposive sampling was used to involve all official lecturers as the participants, and they were 112 people.  This study used a quantitative approach as the research methodology by applying a survey method with path analysis technique. This study used questionnaire as the data collection technique. The researchers had analyzed the instrument before it was distributed to the participants. The instrument was tested by using validity and reliability tests. Three hypotheses were tested. The results showed that transformational leadership had a direct, positive effect on job performance; self-efficacy had a direct, positive effect on the lecturers’ job performance; and the transformational leadership had a direct effect on self-efficacy.
KIRKPATRICK MODEL EVALUATION ON THE IMPLEMENTATION OF STRENGTHENING SCHOOL SUPERVISORS BASED ON BEST PRACTICE, HOTS AND ADULT LEARNING
Authors: Yunus Renny , Diana Nirva , Patimah Siti , Pahrudin Agus
Published: June 2021

Evaluation is a process or activity of selecting, collecting, analyzing and presenting information that can be used as a basis for decision making and for the preparation of further programs. Petronila Jean describes that education and training is the method of technical and vocational education and training which is appreciated as an effort to acquire practical skills, attitudes, understanding and being able to process them in Best Practice and generate an idea or idea about a technique, method, process, activity. , intensive so as to provide them with new knowledge and implications. This study aims to analyze and find outResult Evaluation on the implementation of training to strengthen school supervisors based on Best Practice, HOTS and adult learning. This research method uses qualitative methods with a sample of 100 school supervisors. The data in this study were collected using a questionnaire and reliability testing was carried out with Cronbach Alpha. The results of the study describe the Kirkpatrick Evaluation Model in the Training Program for strengthening school supervisorsThe results of the learning outcomes of the training participants have increased and the difference is significant, it's just that when viewed from each aspect, namely aspects of knowledge, understanding and application, that the results obtained have increased but the results of the differences and the improvements are not significant.
Examining the effect of sports participation motive on aggression
Authors:   School of Physical Education and Sport, Adıyaman University, Turkey, Toktas Sermet
Published: June 2021

This study aims to investigate the relationship between aggression and sports participation motives of Sports High School students in Adıyaman, Kahramanmaraş, and Malatya provinces in Turkey. 575 Sports High School students, including 385 males and 190 females, participated in our research. Surveys used to measure variables included a 30-item sports participation motivation scale a 30-item “aggression inventory”. Reliability and validity studies of the sport participation motive scale were done by Gill et al, and it was determined that Cronbach's alpha coefficients were between 0.30 and 0.78 for the sub-dimensions. The Cronbach's alpha internal consistency coefficient of the aggression scale was calculated as .83. According to our findings, there was a moderately positive relationship between assertiveness, which is the sub-dimension of aggression, and competition, and friends, which is the sub-dimension of the motivation to participate in sports. A moderately significant negative correlation was found with the sub-dimensions of aggression and entertainment, which is the sub-dimension of the motivation to participate in sports. A moderately significant positive relationship was found with destructive aggression, which is the sub-dimensions of aggression, and success and status, and competition, which are the sub-dimensions of participation in sports.
Analysis of Banking Risk, Good Corporate Governance, Capital and Earning Influences on the Indonesia’s Commercial Bank Performances
Authors:   Universitas Pancasila, Indonesia, Subhan M. Nuruddin
Published: June 2021

This study aims to analyze the effect of commercial bank soundness in Indonesia based on Bank Indonesia regulation number 13/24/DPNP date 25 October 2011, which concern on the implementation guide for Bank Regulation in Indonesia number 13/1/PBI/ 2011 on assessment of bank healthy. In general, those assessments cover risks, good corporate governance (GCG), earning and capital. While, the performance of commercial bank is measured based on credit growth and profit growth. A total of 45 commercial banks listed on the Indonesia Stock Exchange are the population of the study which will be analyzed using the structural equation modeling program - partial least square (SEM-PLS). The results show that credit risk, GCG and earnings have no effect on bank’s performance in Indonesia. Market risk, liquidity risk and capital negatively affect the performance of commercial banks in Indonesia. This research is expected to contribute to the policy making of central banks and also commercial bank organization in particular to improve their performance. This research also contributes to the theory by enriching the discussion on related themes.
Green Revolution in Ready Made Garments in Bangladesh: An Analytical Study
Authors: Awal Md. Abdul , Hossan Md. Elius , Aliullah Md. , Saidy Md. Shishir
Published: June 2021

Bangladesh, a small south Asian country, holds the second position in the world of exporting readymade garments (RMG). Here locate the highest number of green RMG factories in the world. Green industrialization is the positive symbol of sustainable development. This paper represents an impressive illustration of the scenario of RMG industries in Bangladesh especially the growth, contribution to export and the success of LEED (Leadership in Energy and Environmental Design) recognized Platinum, Gold and Silver factories. This paper also represents the success of green revolution in RMG industries in Bangladesh and recommends some suggestions to convert the traditional industries to green industries where the industries are not only for making profit but also committed to provide good working environment for employee, eco-friendly and ethical business practice.
Analyzing the Effectiveness of Modern Irrigation Methods in Iraq
Authors: AOthman Ismail I. , Ghasemlounia Redvan
Published: June 2021

Iraq is one of the countries that have water scarcity problem. Many reasons have made this problem to be more complex. The modern irrigation methods have used as one solution to the water problem in Iraq. This paper investigates the effectiveness of modern irrigation methods in Iraq. The paper tests the impact of using modern irrigation methods on the amount of water used for irrigation. The study uses Liner Regression Model (LRM) as a statistical estimation model. The study data were taken from the ministry of water resources, and the ministry of agriculture in Iraq.
This study uses weekly time series data from 2000 -2010. The results show that using modern irrigation methods in Iraq has negative and insignificant impact on the total amount of irrigation water. The results shows that temperature (climate effect) has positive and significant impact on total irrigation water. The results shows that stored water has positive and significant impact on irrigation water.
MEASUREMENT OF THE CONTENT OF MONOETHANOLAMINE DURING THE CONTROL OF THE TECHNOLOGICAL PROCESS OF DESULFURIZATION AND IN THE ENVIRONMENTAL OBJECTS
Authors: Martynova A.Yu. , Larina A.I. , Saraeva V.A.
Published: June 2021

The problem of cleaning coke oven gas from sulfur compounds, despite their recent decrease in the raw material base of coking, remains relevant in connection with the requirements to reduce sulfur dioxide emissions into the atmosphere. When using monoethanolamine for the purification of coke oven gas from sulfur compounds, production workers are faced with the problems of determining the exact concentration both in solutions and in coke oven gas and in environmental objects. The article provides an overview of the currently existing methods for the quantitative determination of the content of monoethanolamine in liquid and gaseous media. The results of studies of the possibility of their use in the conditions of by-product coke production are presented, directions of improvement of the known methods are determined in order to eliminate the influence of accompanying components inherent in by-product coke production (in particular, ammonia, amines, phenols, etc.), which distort the analysis results. The authors describe the methods of increasing the selectivity of analytical methods for determining the content of monoethanolamine in: – coke oven gas - based on the absorption of the test substance from coke oven gas by a solution of orthoboric acid, followed by its determination in a solution with pnitrophenyldiazonium; – the air of the working area under the conditions of by-product coke production - it was proposed to eliminate the negative effect of hydrogen sulfide and phenol using an absorber containing a sodium hydroxide solution located in front of the absorber with a hydrochloric acid solution for monoethanolamine (a revised measurement procedure with additions set out in accordance with the requirements of the current legislation in the field of metrology and established metrological characteristics, agreed by the Chief Sanitary Doctor of Ukraine). The directions of research necessary for the development of a method for determining the content of monoethanolamine in process waters of coke-chemical production are outlined. Keywords: desulfurization, monoethanolamine, content determination, selectivity, ammonia, p-nitrophenyldiazonium, coke oven gas, complex compound, color intensity, photometry, measurements. Corresponding author A.Yu. Martynova, e-mail: alla_martynova_aisim@ukr.net
DISTRIBUTION OF CALORIFIC VALUE BY COKE SIZE CLASS
Authors: Miroshnichenko I.V. , Gavrilyuk V.V. , Miroshnichenko D.V. , Shulga I.V.
Published: June 2021

As is known, the specificity of the layered coking process causes the development of fracturing, which determines the formation of the granulometric composition of the coke. The article presents and analyzes data on the physicochemical properties of coke of various size classes. The expediency of studying the values of the calorific value for different classes of the size of blast furnace coke has been substantiated. For this purpose, ramp coke was taken from batteries that were significantly different in size. In particular, coke oven battery I has almost twice the useful volume of coking chambers and, accordingly, the design capacity than coke oven battery II. In addition, the height of the chambers of coke oven battery I is 7000 mm, and that of coke oven battery II is 4300 mm. The above circumstances must be taken into account when evaluating the heat of combustion of various size classes of blast furnace coke. The composition of the investigated charge consisted of classic grades of coals, which are characterized by their inherent set of quality indicators. The charge for battery I was characterized by a lower burst pressure. It is shown that the value of the highest calorific value of wet quenching blast furnace coke undergoes significant changes depending on the size. Size classes less than 25 mm are characterized by maximum values of the gross calorific value, which reach 33.0 MJ/kg and more. The level of "readiness" of coke, expressed by the value of the yield of volatile substances and the actual density of the coke, significantly affects the value of the highest calorific value. Less "finished" blast furnace coke is characterized by higher values of the gross calorific value for all particle sizes. It is concluded that the value of the highest calorific value of blast furnace coke can serve as a criterion (in addition to those already available) for assessing the degree of "readiness" of blast furnace coke. Keywords: coal, coke, coke size classes, degree of readiness, heat of combustion. Corresponding author Miroshnichenko I.V., e-mail: igor.miroshnichenko@azovstal.com.ua
Investigation of Factors Affecting Pre-School Teachers’ Vocational Alienation
Authors: Mutlu Neşet , Öcal Sümeyye
Published: June 2021

Preschool teachers have an important place in achieving the goals of preschool education and in assuring its quality. Since vocational alienation affect preschool teachers' performance negatively, main purpose of this study is to investigate factors affecting their vocational alienation. For this purpose 227 pre-school teachers from Turkey voluntarily participated in the study. The model of the study was correlational survey model. Research data was collected with; Personal Information Form, Vocational Alienation Scale for the Preschool Teachers (VAS-PT), Organizational Climate Scale and Preschool Teachers' Self-Efficacy Beliefs Scale. According to teachers’ graduation degree variable, the vocational alienation scale scores of teachers at the graduate level differed statistically negatively from other groups (high school, associate degree, undergraduate). The scores of the sub-dimensions of the scale of vocational alienation of the group consisting of teachers who have a different vocation they want to do, differ negatively compared to other colleagues. Between teachers' vocational alienation scores and self-efficacy beliefs and organizational climate scores, positive and negative significant relationships were determined. There were significant negative relationships between teachers' vocational alienation scores and all sub-dimensions of the Self-Efficacy Belief Scale. Negative relationships were determined among the scores of all sub-dimensions of Vocational Alienation Scale for Pre-school Teachers and "Supportive Principle Behavior," "Intimate Teacher Behavior" and “Collaborative Teacher Behavior among Colleagues” of the Organizational Climate Scale. In addition, there were positive relationships between "Disengaged Teacher Behavior" and "Restrictive Principle Behavior" dimensions of Organizational Climate Scale and all sub-dimensions of Vocational Alienation Scale for Pre-school Teachers.
Birth and end of universe & Grand Unified Theories
Authors: Hu Wan-Chung
Published: June 2021

Birth and end of our universe is provided in this deduction. In addition, grand unified field theories are discussed.
PENGARUH DISIPLIN MOTIVASI DAN PELATIHAN TERHADAP KINERJA KARYAWAN PASDA PT. BANK RAKYAT INDONESIA (PERSERO) KALIANDA
Authors: Alam Iskandar Ali , Nurhalimah Tata Putri Ari
Published: June 2021

Masalah sumber daya manusia masih menjadi sorotan utama bagi perusahaan untuk tetap dapat bertahan di era globalisasi. Sumber daya manusia mempunyai peran utama dalam setiap kegiatan perusahaan. Semua tindakan yang diambil dalam setiap kegiatan diprakarsai dan ditentukan oleh manusia yang menjadi anggota perusahaan. Oleh sebab itu keberhasilan suatu organisasi dipengaruhi oleh kinerja individu pegawainya, suatu organisasi akan berupaya untuk meningkatkan kinerja pegawainya dengan harapan dan tujuan perusaan dapat tercapai dengan efektif dan efisien.Dalam penelitian ini menggunakan program SPSS for Windows versi 17.0. Hasil penelitian ini menunjukkan bahwa hasil regresi linier berganda Y = 5,842 + 0,603 X1 + 0,886 X2+ 0,503 X3 maka dapat disimpulkan bahwa sebagian besar responden memilih faktor Motivasi (X2) yang paling besar mempengaruhi Kinerja Karyawan dengan koefisien (0,886%). Hasil analisis uji F, nilai Fhitung sebesar 39,323 dengan signifikan 0,000 lebih kecil dari 0,05 menunjukan bahwa secara bersama-sama variabel Motivasi, dan Pelatihan kerja mempunyai pengaruh positif dan signifikan terhadap Kinerja Karyawan. Hasil analisis uji T, nilai thitung untuk variabel disiplin (X1)sebesar 2,117 motivasi (X2) sebesar 2,230, pelatihan (X3) sebesar 1,695 dengan Ttabel sebesar 2,063 menunjukkan bahwa variable disiplin dan motivasi mempengaruhi kinerja karyawan, sedangkan variable pelatihan tidak mempengaruhi kinerja karyawan. Hasil Koefisien Determinasi (adjusted R2) yang diperoleh sebesar 0,797 itu artinya Kinerja Karyawan dipengaruhi oleh variabel: disiplin, motivasi, dan pelatihan kerja.
2D MOFs have unique features for biological applications. They can be utilized for gene therapy, bioimaging, biosensing, photodynamic therapy, and tissue engineering
Authors: Dowaidar Moataz
Published: June 2021

2D MOFs provide unique properties for use in biological applications, including huge surfaces, programmable functionality and high porosity. This work highlighted the benefits of MOFs for numerous biological applications, including medicinal administration, bioimaging, biosensing, photodynamic therapy, and tissue engineering. The increased surface area of 2D MOFs allows for increased therapeutic agent loading, while the smaller size of 2D MOFs enables increased tumor cell absorption of these complexes due to increased permeability and retention. Also, exterior surfaces of MOFs may be modified to allow fluorophores to be conjugated to them, allowing live cell monitoring of MOFs. Together with its tunability, the high porosity of 2D MOFs can be used for biomolecule sensing. 2D MOFs have also recently been shown to be promising photosensitizers with the potential for photodynamic cancer treatment. In addition, 2D MOFs may be printed with biocompatible binders to form scaffolds for use in tissue engineering applications.Despite the various benefits 2D MOFs give as complex materials with delicate functional characteristics, a few unsolved concerns remain about how to accelerate the development of 2D MOFs for biomedical applications. Differentiating between bulk MOFs and 2D MOFs requires special characterization approaches. This will help define the structure of 2D MOFs and better understand their defect sites, allowing for more effective synthesis strategies.2D MOFs' structural flexibility may be strengthened by using computational and sophisticated features to increase our knowledge of 2D MOFs' crystallography. Scaling up the fabrication of mechanically stable 2D MOFs using cost-effective synthesis while managing MOF size, shape, and porosity is very critical and warrants further consideration in future study. To boost device-based applications, in-situ and in-operando research as well as 2D MOFs' endurance properties are advised. This would facilitate design and manufacture of 2D MOFs with controllable particle sizes, which are particularly useful in optical and photothermal applications. To ensure optimal use of MOFs in biosensing and biomimetic applications, the barriers of ultrathin 2D MOFs must be overcome. 2D MOF aggregation and accompanying instability now also hinder its use in biological applications. This requires processing approaches to boost MOF stability. After developing 2D MOF synthesis procedures, extensive toxicological and biocompatibility research is needed to help translate 2D MOFs. With careful input material selection, including biocompatible metals and effective non-toxic linker materials, current challenges may be handled. Addressing these challenges might also help enhance the design and manufacture of MOFs, which might accelerate clinical translation of 2D MOFs.
ANALISIS PENGENDALIAN PERSEDIAAN BAHAN BAKU BERDASARKAN METODE ECONOMIC ORDER QUANTITY (EOQ) PADA PERUSAHAAN OBOR MAS (ROTI AMIN) BANDAR LAMPUNG
Authors: Alam Iskandar Ali , Anggraini Vera
Published: June 2021

Setiap perusahaan memiliki tujuan utama yaitu memperoleh laba yang optimal dan mengawasi berjalanya perusahaan serta berkembangnya perusahaan. Salah satu cara agar perusahaan memperoleh laba yang optimal adalah menerapkan suatu kebijakan manajemen dengan memperhitungkan persediaan yang optimal salah satunya yaitu persediaan bahan baku. Persediaan bahan baku yang optimal merupakan faktor penting dalam proses kelancaran produksi pada suatu perusahaan. Bahan baku ini dapat dikendalikan dengan menggunakan metode Economic Order Quantity (EOQ) yang memilki tingkat keakuratan perhitungan yang lebih baik dibandingkan dengan metode konvensional.Penelitian ini memiliki jenis penelitian kuantitaif dengan desain berupa penelitian penelusuran. Desain penelitian yang digunakan adalah peneletian kuantitatif yang memiliki tujuan untuk mengakaji lebih dalam tentang penggunaan metode Economic Order Quantity (EOQ) dalam mengendalikan bahan baku Perusahaan Obor Mas (Roti Amin) Bandar Lampung. Objek penelitian ini adalah jumlah pembelian, jumlah persediaan, jumlah pemakaian bahan baku yang digunakan dalam proses produksi, serta biaya pemesanan dan biaya penyimpanan bahan baku. Yang bertujuan mencari pembelian bahan baku yang optimal, frekuensi pembelian yang optimal, persediaan pengaman Safety Stock, titik pemesanan kembali Reorder Point, dan total biaya persediaan yang efisien.Hasil penelitian didapatkan persediaan optimal bahan baku tepung terigu menggunakan metode EOQ sebesar 3.118 kg dengan frekuensi pembelian sebanyak 21 kali, Safety Stock sebesar 1.290 kg dan ROP dilakukan pada saat bahan baku digudang sebesar 1.521 kg denganTIC Rp 3.803.993. Kesimpulan dari penelitian ini adalah perhitungan menggunakan metode EOQ pada bahan baku tepung terigu lebih efisien dibandingkan dengan metode konvensional. Saran yang dianjurkan bagi manajemen Perusahaan Obor Mas (Roti Amin) Bandar Lampung adalah untuk menggunakan metode EOQ dalam proses pengendalian bahan baku perusahaan.
Over-expression of denticleless E3 ubiquitin protein ligase homolog in human endometrial cancer.
Authors: Mamoor Shahan
Published: June 2021

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified denticleless E3 ubiquitin protein ligase homolog, encoded by DTL, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DTL was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DTL was correlated with overall survival in white patients with low mutational burden. DTL may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.
miRNAs have an impact on xeno-infectious diseases by influencing host and/or infection factors
Authors: Dowaidar Moataz
Published: June 2021

This review emphasizes the role of miRNAs in related illnesses. miRNAs have been found to play a role in both normal and pathological biological processes by directly or indirectly regulating numerous cellular transcripts via epigenetic-related enzymes, interfering with lncRNA and CeRNA activities, and interfering with lncRNA and CeRNA activities, according to numerous studies. They also have an impact on xeno-infectious diseases by influencing host and/or infection factors such as related transcripts and proteins, among other things. On the other hand, complications in their miRNAs' structure, such as isomiRs, arm selection, and arm switching, might reveal how significant miRNAs are in the development of various illnesses. Xeno-infectious agents such as viruses, parasites, and bacteria, among others, can impact miRNA structural characteristics and interactions with epigenetics and other non-coding intracellular RNAs. As a result, miRNAs should be investigated further since they are important prognostic and diagnostic markers. Furthermore, because miRNAs provide new insights into some mechanisms of complex diseases like cancer, neurodegenerative disease, and xeno-infectious disease that can be used effectively in personalized medicine to control the diseases, more research from the bench to the bedside is needed before they can be used as therapeutic agents.
TUGAS HTN PEMILU DAN POLITIK MUHAMMAD NUR HAIKAL
Authors: MUH HAIKAL
Published: June 2021

Menurut Budiardjo partai politik adalah sekelompok orang yang terorganisasir yang anggota-anggotanya mempunyai orientasi, nilai-nilai, dan cita-cita yang sama. Tujuan kelompok ini ialah untuk memperoleh kekuasaan politik dan merebut kedudukan politik (biasanya) dengan cara konstitusional untuk melkasnakan programnya. Sedangkan menurut Giovani Sartori partai politik adalah suatu kelompok poloitik yang mengikuti pemilihan umum dan, melalui pemilihan umum itu mampu menempatkan calon-calonya untuk menduduki jabatn-jabatan politik.
30 juta umkm ditargetkan melek teknologi di tahun 2023
Authors: Andreas Andrean Cristian
Published: June 2021

Inovasi dalam upaya menghasilkan kinerja bisnis yang luar biasa, terutama untuk mencapai maksimalisasi keuntungan dan maksimalisasi kekayaan. Penelitian kualitatif deskriptif, dengan studi kasus intrinsik berdasarkan pengumpulan data dan tinjauan pustaka, dimaksudkan untuk menganalisis dan mencari solusi bagi perusahaan dalam menghadapi perubahan perilaku dan selera konsumen serta kondisi pasar. Implikasi dari penelitian ini adalah pimpinan perusahaan dapat mengakomodasi perubahan kebutuhan konsumen dan memberikan organisasi yang positif untuk mendorong karyawan berinovasi dan berkreasi guna memenuhi potensi permintaan.
KEBUTUHAN ZAT GIZI DAN PENILAIAN STATUS GIZI
Authors: Hadza Roza Qoni
Published: June 2021

Ada dua metode penilaian status gizi ini yaitu penilaian status gizi langsung yang terdiri dari antropometri, klinis, biokimia, biofisik, dan penilaian tidak langsung terdiri dari survei konsumsi makanan, statistik vital, faktor ekologi. Dengan begitu banyaknya metode penilaian status gizi maka perlu dipertimbangkan faktor untuk memilih metode penilaian yaitu tujuan, unit sampel yang akan diukur, jenis informasi yang dibutuhkan, tingkat reliabilitas dan akurasi yang dibutuhkan, fasilitas & peralatan yang ada, tenaga, waktu, dan dana yang tersedia.
TUGAS UAS PEREKONOMIAN INDONESIA
Authors: Sinambela Gabriel David Pangihutan
Published: June 2021

tugas perekonomian indonesia yang berisi tentang pentingnya untuk menjaga ke stabilan umkm agar bisa menopang erekonomian indinesia yang dimana perlu dketahui juga umkm juga dapat berperan sebagai penjaga kestabilan sekonomi. disisi lain umkm juga perlu ditingkatkan agar terus berkembang
CRISPR–Cas9 gene editing as a tool for developing immunotherapy for cancer
Authors: Dowaidar Moataz
Published: June 2021

T cells following genome editing and transformation might be detectable in peripheral blood and tumor tissues for a long time, even more than a year. The types and diversity of T-cells in peripheral blood and tumor tissues changed following transfusion of genetically modified T-cells, and some highly suspected T-cells targeting cancer cells grew, increasing the proportion of such cells. Moreover, after getting genetically engineered T cells, anticancer cytokine secretion increased. T cells changed by gene editing have certain functions, at least from an immunological standpoint. The first clinical research using the CRISPR–Cas9 gene editing method for cancer resistance is more complicated: Using CRISPR–Cas9 gene editing technology to concurrently knock out, amplify, activate and reinfuse three genes in human immune cells. This therapeutic strategy is more demanding, because the changed immune cells have a wider target scope. The data suggest that the efficacy of gene editing in immune cells was 15–45%, and the modified cells could survive long in the peripheral blood and tumor tissues of patients. After three or four months, some T-cells became central T-cells. These encouraging findings pave the way for future experimental cancer research utilizing CRISPR technology.
Frontotemporal dementia is a complex disorder with a wide spectrum of clinical symptoms. Personalized medicine and gene therapy are promising strategies for treatment
Authors: Dowaidar Moataz
Published: June 2021

Frontotemporal dementia is an uncommon and complex sickness with a wide spectrum of clinical symptoms, making drug development for the condition challenging. Frontal and temporal lobe responsibilities, as well as the level to which these activities are affected in certain diseases, contribute to clinical heterogeneity. Unfortunately, the available data on symptomatic treatments is drawn from limited case studies and RCTs, which include persons with the same FTD diagnosis. Advances in the identification of new FTD treatments demand the construction of huge clinical networks that are built on collaborative, multicenter research. One of the primary drawbacks of the present studies is the variety of the assessment instruments utilized, such as the FBI, Cambridge Behavioral Inventory, NPI, and BEHAVE-AD, some of which were not originally established for FTD but were first validated for other kinds of dementia, such as AD. The FBI was shown to have high sensitivity and specificity in discriminating between bvFTD and non-FTD, whereas the NPI score did not.The new definition of Alzheimer's disease was changed from a clinical diagnostic to a biomarker-based diagnostic, although we are still a long way from providing a scientific description of FTD. In the future, there might be an increased likelihood of recognizing symptoms or signs in clinical studies because of a revision to the criteria of FTD.Treatment techniques should be customized to individual patient subgroups or mutation carriers. Currently, as a treatment for FTD-tau, antisense oligonucleotide inhibition of MAPT, tau phosphorylation inhibition, microtubule stability, and inhibition of tau aggregation are all being investigated. It is possible to inhibit TDP-43 aggregation, enhance progranulin levels, activate the autophagy–lysosome system, or modify the ubiquitin-proteasome system in FTD-TDP. Despite these breakthroughs, the etiology and genetics of FTD remain unclear. Additional genetic pathways and loci associated with immune dysregulation and inflammation have recently been discovered, furthering the search for possible treatment targets. Also, knowing who the mutation carriers are early on allows researchers to test disease-modifying drugs earlier, when cognitive problems may still be reversible.Research gaps in the etiology and clinical characterization of FTD should be resolved, as well as the production of precise biomarkers and specialized evaluation methodologies. Desharnais and colleagues have created a checklist to assist standardize future FTD clinical trials and boost the probability of successful findings.
Doing science with the wonder in the child’s eyes
Authors: Le Tam-Tri
Published: June 2021

My personal perspective about doing science stemming from childhood experience.
Gene therapy promises accurate, targeted administration and overcoming drug resistance in diverse cancer cells
Authors: Dowaidar Moataz
Published: June 2021

Nucleic acid-based therapeutics such as siRNA and miRNA employ the silencing capabilities of the RNAi mechanism to affect the expression of one gene or several genes in target cells. Nucleic acid-based therapies enable accurate, targeted administration and overcoming drug resistance in diverse cancer cells. Several studies have shown that they can be utilized alongside pharmacological therapy to increase the efficacy of existing therapies. In addition, nucleic acid-based therapies have the potential to widen the spectrum of druggable targets for a range of diseases and emerge as a novel therapeutic technique for treating a number of diseases that are today untreatable. Nucleic acids are dependent on their effective distribution to target cells, which need correct complexation and encapsulation in a delivery mechanism. Although nucleic acids exist in a variety of forms and sizes, their physical and chemical commonality allow them to be loaded into a wide range of delivery vehicles. The primary biomaterials used to encapsulate genetic components were cationic lipids and polymers. Furthermore, the experiments focused particularly on effective transfection in target cells.Recent breakthroughs in NP-based RNA therapeutics have spurred a flood of clinical research, facing many challenges. In vivo, pharmacokinetics of different RNA-based medications must be researched to establish the viability and therapeutic potential of nucleic acid-based therapeutics. The U.S. Food and Drug Administration recently authorized many NP-based gene therapy. In 2019, Novartis authorized Zolgensma (onasemnogene abeparvovec-xioi) to treat spinal muscle atrophy. The first clinical research employing siRNA began in 2004 and is considered a milestone in nucleic acid-based drug development. Thirty clinical investigations have subsequently been completed. In 2018, the US FDA cleared Onpattro (Patisiran, Alnylam Pharmaceuticals) for the treatment of polyneuropathy caused by transthyretin amyloidosis.Several new generations of nucleic acid compositions employing polymer nanoparticles or liposomes are presently undergoing clinical testing. If allowed, the debut of nucleic acid-based treatments would represent a watershed event in immunotherapy. Advances in the design and development of biocompatible nanomaterials would allow us to overcome the above-mentioned problems and so show the potential to deliver nucleic acids in the treatment of a number of illnesses.
Sumber Zat Gizi dan Penilaian Status Gizi
Authors: Hadza Roza Qoni
Published: June 2021

Sumber zat gizi terbagi 2 yaitu gizi makro terdiri atas karbohidrat,protein dan lemak, sedangkan zat gizi mikro terdiri atas mineral dan vitamin. Ada dua metode penilaian status gizi ini yaitu penilaian status gizi langsung yang terdiri dari antropometri, klinis, biokimia, biofisik, dan penilaian tidak langsung terdiri dari survei konsumsi makanan, statistik vital, faktor ekologi.
Immune evasion is linked to histone variation malfunction. Gene therapy could provide tools for targeting histone variant deposition as a critical part of its pharmacology
Authors: Dowaidar Moataz
Published: June 2021

For a range of cancer-related processes, histone variants play a function. MacroH2A1.1's ADP ribose-binding properties have emerged as a connection between metabolites and the epigenome that must be studied further in vivo. Based on the data we have discovered thus far, we think that altered histone variant functions are co-opted by transformed cells with varying outcomes over the evolutionary trajectory of the tumor. However, our current understanding of histone variations in tumor dormancy and treatment resistance is insufficient. H3 mutations are most common in solid tumors, but they have also been found in hematological malignancies.In addition, a study of over 3,000 patient samples from various cancer types found that all core histones are mutated in 4% of cancers, but the role of these newly formed mutations is unknown.However, an ongoing study is investigating how to better characterize tumor response, as well as how to better predict patient survival in difficult-to-treat cancers. Based on many studies, we hypothesize that altered gene expression levels in tumor cells or tumor-associated cells can change the immunological microenvironment. Histone variation dysfunction influences the genes associated with immune evasion, which in turn affects immune-therapy responsiveness.The success of our goal depends on developing unique, pharmacologically practical ways to target histone variant deposition. Since histone chaperones lack enzymatic capabilities and possess large surfaces without deep pockets where small-molecule inhibitors may act, this has proven problematic thus far. Since cell identity is dependent on histone variants and chaperones, it is reasonable to ponder if cell destiny is lost due to histone variant and chaperone regulation. Histone variants may still be utilized to predict therapeutic response while we wait for these data, helping to personalize treatments and enhancing patient survival and quality of life.
The Effect of Teaching Science through Storytelling on Students’ Academic Achievement, Story Writing Skills and Opinions about Practice
Authors: Demirci Tuba , Okur Sema
Published: June 2021

This study aims to compare the effect of storytelling in teaching on students' academic achievement with the traditional teaching method. In addition, it aims to reveal the effect of story education given to students on students' story writing skills and their opinions regarding storytelling in teaching. The study was carried out in a public primary school. The mixed research method was employed in the study. A total of 61 primary school 3rd-grade students, 31 experiments and 30 controls, participated in the study. The "Academic Achievement Test" was applied to the experimental and control group students to collect quantitative data. The journey to the world of living beings unit was taught in the experimental group for four weeks by using the stories prepared by the researcher. At the end of each lesson, the students were asked to write a science story on the subject. The "Story Writing Skills Evaluation Scale" was used to determine the change in the story writing skills of the experimental group students, and the "Student Opinion Form on Storytelling" was used to reveal the students' thoughts about storytelling in teaching activities. The traditional teaching method was used in the control group. The quantitative data used in the study were analyzed using the SPSS statistical software. The qualitative data were analyzed using content analysis. Among the quantitative findings of the study, while there was no significant difference found between the pre-test mean scores of the experimental and control groups achievement test, a significant difference was found between the post-test scores in favor of the experimental group. The other quantitative finding of the study, in the evaluation of story writing skill, a significant difference was found between the first and the last story in favor of the last story. Positive findings were also obtained in the qualitative dimension of the study, such as the experimental group students are not unfamiliar with stories, it is fun for them to use in science lessons, and can be used in other lessons.
Parkinson's disease Simulating complexity via improving the identification of significant genetic alterations and environmental contaminants should be a priority
Authors: Dowaidar Moataz
Published: June 2021

Despite great improvements, more research is required to model Parkinson's complex neurodegenerative disease. Simulating the disease's complexity via improving the identification of significant genetic alterations and environmental contaminants should be a priority. Furthermore, because environmental toxins are typically exposed in a variety of combinations and over long periods of time, future research on Parkinson's disease modeling should take into account the diversity of hazardous exposures. To successfully mimic the impact of environmental contaminants on Parkinson's disease development, toxic exposure should be done through physiological channels as well, with chronic exposure regimens preferred over acute exposure regimens.
Research into P2X purinergic receptor function in tumor growth has made substantial progress with potential gene therapy targeting
Authors: Dowaidar Moataz
Published: June 2021

Tumor development is a complex molecular process, and treating it remains the most challenging problem to address at this moment. It is vital to comprehend and explain the molecular foundation of cancer genesis, as well as to uncover novel targets for tumor prevention and therapy. Thankfully, research into the role of P2X purinergic receptors in tumor formation has made substantial progress. The activation of P2X purinergic receptors by ATP aids the control of tumor cell proliferation and fate. P2X purinergic receptor activation can either stimulate or inhibit tumor cell proliferation. While the effects of P2X4 and P2X7 receptors are the most obvious, they can act directly on tumor cells as well as indirectly through immune cells to control tumor progression. In most studies, P2X purinergic receptor antagonists have been shown to prevent their activation, reduce their expression level, and halt tumor progression. As a result, developing P2X-specific antagonists or selective antagonists for tumor treatment has a lot of potential and might be a novel molecular pharmacological target for tumor treatment.
Haemophilia gene therapy is in clinical studies, making continuous safety and efficacy testing a key emphasis
Authors: Dowaidar Moataz
Published: June 2021

Patients and clinicians worldwide seeking access to gene therapy, lentiviral vector or gene editing-mediated gene therapy may become feasible options. Several nations have built vectors, manufacturing and regulatory methods and either run separate clinical trials or participate in international trials in order to get access to and experience.Vector safety and effectiveness across habitats should be identical. The dilemma of whether to utilize larger or lower vector doses or whether to seek higher or lower steady-state factor levels remains unanswered. Multiple vector-specific factors (preclinical data, early trial data, threshold effect presence, interpatient dose-expression relationship variability, or dose and risk of transaminitis relationship, estimated expression duration) as well as cost-effectiveness analyzes for each setting are all relevant to the vector dose decision (including data on the healthcare system, economics, available alternative treatments, accepted goal for quality of life or contribution of patients to society). Because patients are unlikely to get a second vector dosage, the initial dosage should be delivered and monitored under optimum conditions, especially to avoid early expression loss due to uncontrolled transaminitis.In clinical research, haemophilia gene therapy is crucial to continuing safety and efficacy testing. Communicating and coordinating internationally is crucial to providing worldwide access to gene therapy, avoiding a new gap in haemophilia care, raising awareness, sharing knowledge and experience, and building suitable infrastructure and regulatory and financial platforms.