bluuebunny/crossref_metadata_2025 huggingface dataset:
EDUCAÇÃO PROFISSIONAL, INICIAÇÃO CIENTÍFICA E ÊXITO DISCENTE: O CORPO DISCENTE QUE FAZ INICIAÇÃO CIENTÍFICA NOS CAMPI AGRÍCOLAS DO INSTITUTO FEDERAL DE PERNAMBUCO
Authors: FILHO ALBERTO BELO ESTEVES , SILVA LUIS LUCAS DANTAS DA , LIRA MAGADÃ MARINHO ROCHA DE
Published: May 2023

Atualmente, a evasão escolar é um problema grave em todos os níveis de ensino e a rede federal de educação profissional, científica e tecnológica também sofre com isto. O objetivo deste trabalho foi compreender a relação entre êxito escolar e educação profissional, a partir da ênfase do quantitativo de aprovados nos cursos dos campi agrícolas do IFPE que participaram da Iniciação Científica. Foram utilizadas nesta pesquisa as técnicas de Pesquisa Bibliográfica e Documental. Foram analisados os dados a partir de 2015, fornecidos pela PROPESQ do IFPE de todos os alunos do Curso Técnico Integrado ao Ensino Médio e Curso Técnico Subsequente dos Campi agrícolas que participaram de algum programa de pesquisa da instituição. Estes dados foram confrontados com os registros escolares dos estudantes no Q-acadêmico para averiguação do êxito do estudante pesquisador na conclusão do respectivo curso técnico. Após análise dos dados fornecidos pela PROPRESQ, especificamente dos três Campi agrícolas do IFPE para os ciclos de Iniciação científica (IC) 2015 a 2019, observou-se uma tendência de êxito na conclusão dos cursos técnicos integrados e subsequentes quando os estudantes foram pesquisadores. Conclui-se assim que a pesquisa é um instrumento valoroso para fixar os jovens dentro das instituições e despertar neles a vocação profissional. Palavras-chave: educação; iniciação científica; campi agrícola; evasão; êxito.
Frequency Of Unnecessary Caesarean Section In Tertiary Care Teaching Hospital
Authors: Azra Noor , Fatima Noor , Gull Atia , Akber Erum
Published: May 2023

The unnecessary caesarean section is common now a day. It is done due to many reasons with absolute indication, relative indication and no indication. It is possible to predict that the Sustainable Development Goals may be hampered by the overuse, unsafe provision, and unmet need of CS. All health systems must ensure that all women have timely access to caesarean sections when necessary because they are absolutely necessary to save lives in cases where vaginal deliveries would be dangerous. The study's design was cross-sectional descriptive. From October 2020 until January 2021, it was carried out. In all, 376 questionnaires were completed using secondary data from patient records in the gynecology record room of the Tertiary Care Teaching Hospital (TCTH) Lahore. The research is based on data on the most recent birth of ever-married women between the ages of 15 and 45 who have since given birth. study findings have revealed the absolute indications, relative indications and no indication. 48.2% women had absolute indications of cesarean section, 23.3% had relative indication and 28.4% cesarean section done without indications. Moreover, it also shed light on the pros and cons of unnecessary cesarean.
Metastatic secondary gliosarcoma: patient series
Authors: Baisiwala Shivani , Ko Myungjun , Zubair Humza , Li Kevin , Vivas Andrew C. , Everson Richard , Liau Linda , Bari Ausaf , Patel Kunal S.
Published: May 2023

BACKGROUND

Gliosarcoma is a rare and highly malignant cancer of the central nervous system with the ability to metastasize. Secondary gliosarcoma, or the evolution of a spindle cell–predominant tumor after the diagnosis of a World Health Organization grade IV glioblastoma, has also been shown to metastasize. There is little information on metastatic secondary gliosarcoma.

OBSERVATIONS

The authors present a series of 7 patients with previously diagnosed glioblastoma presenting with recurrent tumor and associated metastases with repeat tissue diagnosis consistent with gliosarcoma. The authors describe the clinical, imaging, and pathological characteristics in addition to carrying out a systematic review on metastases in secondary gliosarcoma.

LESSONS

The present institutional series and the systematic review of the literature show that metastatic secondary gliosarcoma is a highly aggressive disease with a poor prognosis.
Technical advantages of a novel flow diverter in complex flow diversion: patient series
Authors: Lei Catherine , Heskett Cody , Fry Lane , Brake Aaron , De Stefano Frank A. , Peterson Jeremy , Ebersole Koji
Published: May 2023

BACKGROUND

The Surpass Streamline flow diverter (SSFD) possesses 4 attributes that may offer an important advantage in the treatment of complex pathologies: (1) utilization of an over-the-wire (OTW) delivery system, (2) greater device length, (3) larger potential diameter, and (4) propensity to open in tortuosity.

OBSERVATIONS

Case 1 leveraged device diameter to embolize a large, recurrent vertebral artery aneurysm. Angiography at 1 year posttreatment showed complete occlusion with a patent SSFD. Case 2 leveraged device length and opening in tortuosity to manage a symptomatic 20-mm cavernous carotid aneurysm. Magnetic resonance imaging at 2 years demonstrated aneurysm thrombosis and patent stents. Case 3 utilized diameter, length, and the OTW delivery system to treat a giant intracranial aneurysm previously treated with surgical ligation and a high-flow bypass procedure. Angiography at 5 months postprocedure demonstrated the return of laminar flow, as the vein graft had healed around the stent construct. Case 4 used diameter, length, and the OTW system to treat a giant, symptomatic, dolichoectatic vertebrobasilar aneurysm. Twelve-month follow-up imaging revealed a patent stent construct with no change to the aneurysm size.

LESSONS

Increased awareness of the unique attributes of the SSFD may allow a larger number of cases to be treated with the proven mechanism of flow diversion.
MODERN MARKERS OF OSTEODYSMETABOLIC SYNDROME
Authors: Plaksa V.M.
Published: May 2023

Osteoporosis is a prevalent systemic osteodysmetabolic disease affecting bone tissue, characterized by a loss of bone mass, microstructure disturbances, and an increased susceptibility to low-traumatic fractures. Global statistical data from 2019 indicate that 32 million people worldwide were diagnosed with osteoporosis, with 25.5 million being women and 6.5 million men. Hypoestrogeny, considered one of the key mechanisms in the development of osteometabolic syndrome, disrupts the RANK/RANKL/OTG signalling system by activating nuclear factor-κB (NF-KB) or STAT-3. This activation triggers osteoclastogenesis and subsequently leads to the development of osteoporosis, which is a significant global health concern.

The aim of this study is to investigate the specific features of osteometabolic changes in bone tissue and assess the 10-year risks of osteoporotic fractures and hip fractures. An examination was conducted on 130 individuals (116 women and 14 men) with an average age of 55.3±15.4 years. The participants were further divided into three groups: Group I (main group, n=85), Group II (control group, n=31), and Group III (comparative group, n=14). Anthropometric parameters were evaluated, revealing deviations in body mass index (BMI) from the norm. The average BMI values were as follows: Group I - 27.2±5.2 kg/m2, Group II - 23.4±4.3 kg/m2, and Group III - 25.8±3.5 kg/m2 (p = 0.0013).

Estimating the 10-year probability of developing osteoporotic fractures using the FRAX model indicated a higher likelihood in the main group compared to the control group (7.4% [4.0–15.0%] vs. 2.7% [2.4–3.3%], p = 0.0001). When analyzing the 10-year risk of hip fracture, the results were as follows: Group I - 1.1% [0.2–5.1%], Group II - 0.1% [0–0.3%], and Group III - 0.15% [0.1–0.4%] (p = 0.0001). These findings suggest the activation of systemic inflammatory pathways as a consequence of hypoestrogenism in women from the main group.

This study clearly demonstrates a higher likelihood of 10 different osteoporotic fractures and hip fractures, as indicated by the FRAX model, in the main group compared to Groups II and III. Therefore, utilizing ultrasound densitometry in conjunction with the FRAX model can help prevent the occurrence of osteoporotic fractures and hip fractures. Furthermore, when changes in tissue mineral density and markers of systemic inflammation are detected, it enables the development of gender-specific approaches for further diagnosis and treatment
ANALYSIS OF COVID-19 IMPACT ON THE STATE OF HEALTH AND CARDIOVASCULAR FUNCTION OF CHILDREN 7-9 YEARS OLD
Authors: Vasyleha P.A.
Published: May 2023

Influenza and acute respiratory viral infections pose significant challenges in paediatrics, given their high prevalence among children and the potential for severe and complicated cases, particularly in young age groups. Over the past 20 years, there have been three coronavirus epidemics that have caused a substantial number of severe cases, high mortality rates, and global transmission. This review aims to provide a comparative analysis of clinical and epidemiological features of coronavirus infections in children, drawing from the examples of SARS and MERS, and offers essential approaches and recommendations for the diagnosis and treatment of COVID-19. The review covers the etiology, epidemiology, laboratory diagnosis, clinical presentation, and treatment of severe acute respiratory syndrome. It also provides a brief historical overview of the epidemiology, diagnosis, and treatment of this disease. Unlike other respiratory viral infections, COVID-19 can result in persistent symptoms following the acute phase, known as post-infection COVID-19 syndrome, which can last for weeks or even months. The long-term effects of COVID-19 in children are not yet fully understood, and further research is needed to explore its true prevalence, pathogenesis, and lasting impacts. The management of paediatric post-infection COVID-19 syndrome requires a multidisciplinary approach, international collaboration, and consensus to ensure early detection and effective treatment in children.

The article presents current scientific insights into the factors contributing to the development of a prolonged post-COVID period, including chronic systemic inflammation, endothelial dysfunction, coagulation disorders, autoimmune reactions, and other immunological changes. The COVID-19 outbreak serves as a reminder of the ongoing threat posed by infectious diseases caused by pathogenic viruses, highlighting the need for global cooperation and preparedness to effectively mitigate their spread.
HEADACHE AND COVID-19: ETIOPATHOGENETIC LINKS, DIAGNOSTIC FEATURES AND TREATMETN APPROACHES
Authors: Ivashchenko S.P. , Delva M.Yu.
Published: May 2023

COVID-19 is a human respiratory disease caused by the SARS-CoV-2 coronavirus. However, in most cases, COVID-19 is accompanied by neurological involvement, leading to persistent consequences. Even individuals, both adults and children, with mild forms of the disease may experience recurrent neurological and neuropsychiatric symptoms following the acute phase and beyond. Headache is one of the most common early symptoms of COVID-19. Beyond being a clinical condition, it significantly impacts the quality of life and poses an economic burden on society. Throughout the ongoing COVID-19 pandemic, headache has emerged as a serious neurological symptom associated with SARS-CoV-2 infection and is even considered among its cardinal symptoms. In this review, we highlight the latest research publications on headache as a symptom of post-COVID syndrome based on data published over the past 3 years. The purpose of this study is to enhance the management of patients with post-COVID headache by analyzing studies investigating the prevalence, pathogenesis, and phenotypic characteristics of headache following COVID-19. By identifying existing challenges and seeking optimal solutions, we aim to optimize the care and treatment of patients experiencing post-COVID headache. Among the pronounced features of SARS-CoV-2 infection there is the ability to cause exacerbation (increased intensity, frequency, duration of headache attacks) or chronic headache in patients with a history of primary headache. In addition, patients with COVID-19 and a history of primary headache may develop a qualitatively new headache during the acute phase of the disease.

To date, there are no specific treatments, and most clinicians treat headache after COVID-19 based on the similarity of the clinical phenotype to other types of primary headache. Given the significant negative impact of headache in COVID-19, additional research is needed to make informed choices about optimal treatment methods. Thus, the problem of headache in patients who have experienced COVID 19 is an urgent medical and social challenge that requires relevant modern knowledge for its timely diagnosis and effective management.
CLINICAL AND PHARMACOLOGICAL ASPECTS OF ANTIFUNGAL AGENTS IN STOMATOLOGYCAL PRACTICE
Authors: Ostrovska G.Yu. , Moisieieva N.V. , Lutsenko R.V. , Petrova T.A. , Rozkolupa N.V. , Vlasova O.V.
Published: May 2023

According to the World Health Organization, fungal infections account for 20-70% of diseases worldwide. This high prevalence is influenced significantly by social, medical, and pharmacological factors. Treating candidiasis poses challenges due to the characteristics of the causative agent, its adaptability to environmental conditions, and resistance to commonly used drugs. The increased occurrence of fungal infections in the oral cavity can be attributed to various risk factors such as prosthetic surface adhesion, poor habits, altered oral cavity pH, saliva quantity, iatrogenic factors, and comorbidities in patients. Candidal stomatitis treatment is complicated by the Candida genus's tolerance to traditional antifungal drugs, decreased immune reactivity, and the lack of effective treatment and prevention strategies for candidiasis in patients receiving antibacterial drugs and glucocorticosteroids. It is important to recognize that candidiasis is often a symptom of underlying conditions, emphasizing the need for a comprehensive approach, caution, and extensive knowledge in its treatment. Dentists dealing with mycosis-related issues play a crucial role in enhancing antifungal therapy and developing evidence-based pharmacotherapy standards. Therefore, it is essential to keep healthcare professionals informed about the clinical and pharmacological characteristics of antifungal drugs in a timely manner. This study aims to analyze contemporary literature regarding the clinical and pharmacological aspects of antifungal drugs in dental practice. The analysis of existing sources highlights several widely accepted principles of pharmacotherapy for fungal lesions of the oral mucosa, including selecting antifungal drugs based on their selectivity against specific pathogens or using combination therapies. Other factors to consider are the underlying cause of the disease, patient age, comorbidities, and the pharmacokinetics and toxicity profile of antifungal agents. Effective treatment of fungal infections requires a combination of local and systemic approaches, adhering strictly to prescribed drug dosages and treatment durations. The task for practicing clinicians facing challenges in managing oral mucosal mycoses is to enhance therapy using currently available antifungals and develop modern pharmacotherapy standards based on evidence-based medicine
ANTIVIRAL DRUGS IN THE TREATMENT FOR COVID-19
Authors: Sydorenko A.H.
Published: May 2023

Introduction. Covid-19 is an infectious contagious disease of viral etiology caused by SARS-COv-2.

Covid-19 is a highly infectious viral disease caused by SARS-CoV-2. The management of Covid-19 presents significant challenges, and the decision regarding the level of medical care provided, whether in outpatient or hospital settings, relies primarily on the clinical assessment of the patient's condition.

The aim of this paper is to review and analyze the pharmacological properties of antiviral drugs used in the treatment regimens for Covid-19.

Materials and Methods: In this research, internet resources such as PubMed, Google Scholar, and CrossRef were utilized. The focus was on providing an up-to-date review of the pharmacokinetic and pharmacodynamic characteristics of antiviral drugs used in the treatment of Covid-19.

Monlupiravir is an antiviral prodrug with activity against SARS-CoV-2. It is prescribed for patients with mild to moderate Covid-19 who are at high risk of developing severe forms of the disease or death. Ribavirin is a nucleoside analogue with broad-spectrum antiviral activity. Remdesivir is a direct-acting antiviral drug that inhibits the RNA-dependent RNA polymerase, and it is indicated for seriously ill Covid-19 patients with pneumonia requiring oxygen therapy, as well as for patients with comorbidities such as diabetes mellitus, respiratory and cardiovascular diseases, immunosuppressive conditions, and renal failure.

Favipiravin is a direct-acting synthetic antiviral drug, selective RNA polymerase inhibitor, which is indicated for the treatment of moderate and severe COVID-19, pandemic infections caused by influenza virus, and also when other drugs are ineffective.

Lopinavir/ritonavir is a combination drug, a protease inhibitor, which is used in the treatment charts for seriously ill patients with COVID-19.

Conclusion. The search for effective etiotropic drugs for treatment of patients with COVID-19 is still continuing. Monlupiravir, ribavirin, remdesivir, favipiravin, plitidepsin, lopinavir / ritonavir are used for treatment. Mechanism of drugs’ action, peculiarities of their pharmacokinetics and pharmacodynamics, possible side effects, dosage forms are required for the choice of the drug.

Favipiravir is a synthetic antiviral drug that acts as a selective RNA polymerase inhibitor. It is indicated for the treatment of moderate to severe Covid-19, as well as for pandemic influenza infections when other drugs are ineffective. Lopinavir/ritonavir is a combination drug and a protease inhibitor used in the treatment of severely ill patients with Covid-19.
CLINICAL SIGNIFICANCE OF CELLULAR AND MOLECULAR COMPONENTS OF BLOOD-BRAIN-BARRIER
Authors: Stromylo A. V. , Kykhtenko O. V.
Published: May 2023

The purpose of the study is to analyze the literature on the micromorphological and molecular features of the blood-brain barrier and then to establish the value of the obtained data for clinical disciplines in the context of diagnosis and explanation of the mechanisms of nerve tissue degeneration.

Results and discussion. According to the danger of negative dynamics of the epidemiology of nervous system diseases among global population we decided to analyze the literature as for the role of cell and molecular components of the blood-brain barrier for diagnostics, explaining of pathogenesis and making a disease prognosis in cases of neuronal disorders (anatomy and physiology changes in blood-brain barrier in cases of neuron damaging is often mentioned in scientific works). In this article micromorphological and molecular structure of the blood-brain barrier were described. The role of components of neurovascular units for maintaining normal barrier functions of blood-brain barrier was also found out. We described pathomorphological and functional changes in blood-brain barrier in condition of central nervous system damages, such as increasing of blood-brain barrier permeability and disruption of its barrier functions, which are worsened by insufficient neurotoxin excretion and decreasing of energy supply of neurons. The role of perycytes and astocytes in neurodegeneration was also explained in this article. We paid much attention to molecular markers of components of neurovascular units (such as neuron-specific enolase, acidic glial protein, protein S100β, PDGFRβ, TYMP and the marker of blood-brain barrier integrity – albumin index) because of its possibility of being used as a method of evaluation of the functional state of cells (due to measurement of level of these molecules in serum or cerebrospinal fluid) before their interfering into pathological process and for evaluation of blood-brain barrier density. But unfortunately, changes of concentrations of the most part of them appeared to be not specific enough for being interpreted as increasing of blood-brain barrier permeability, but can be explained also by brain injury, neurodegeneration or severe cardiovascular failure. Another problem of analysis of biomarkers is difficulties with integrating of their measurement in clinical practice because the significant part of data was found out due to invasive methods of studying or even making an autopsy. This way or another, further researches of them are necessary.

Conclusion. We suppose genetics studying to be a possible solution of mentioned problems. They can be not only a possible diagnostic method but an object of target therapy (for example, ABCB1 gene which encodes P-gp – the protein which could be considered as a transporter of neurotoxins or APOE4 gene which is supposed to correlate with the severity of neurodegeneration).
OXIDATIVE MECHANISMS UNDERLYING BRAIN CELL DAMAGE IN RATS UNDER CHANGES IN DURATION OF THE LIGHTDARK CYCLES
Authors: Volkova O.A.
Published: May 2023

One of the main mechanisms underlying cell damage is lipid peroxidation, which is characterized by increased levels of free radical, products of lipid peroxidation chain reactions, and alterations in the activity of the antioxidant system in tissues. Therefore, the objective of this study is to investigate the proand antioxidant balance in rat brain homogenate under conditions of disrupted "light-dark" cycles. The study involved 28 white Wistar rats weighing 150-200 gm, divided into two groups: control (15) and the group of animals exposed to acute desynchronosis simulation (13). To simulate desynchronosis, a normal "light-dark" cycle of 12 hours of light and 12 hours of darkness was initially established for three weeks, followed by a shift of the "light-dark" phases backward by six hours over the next three days. The animals were kept in standard conditions with a balanced diet in the vivarium, and the study adhered to the principles of biomedical ethics.

The results obtained indicate a significant increase in the activity of superoxide anion radical production in the brain tissues of the rats with modelled desynchronosis by 75.8% compared to the control group. This increase is attributed to the NADPH-oxidase mechanism by 20.2% and to xanthine oxidase mechanisms by 28%. The concentration of TBA-active products increased by 36.8%, the growth of TBA-active products elevated by 30%, and the activity of the key antioxidant enzymes, superoxide dismutase and catalase, decreased by 53% and 14%, respectively, in the second group of animals. Furthermore, in the brain tissues of rats with disrupted "light-dark" cycles, there were found elevated levels of nitrites by 23.8%, nitrosothiols by 19%, and peroxynitrites by 69%, along with a reduction in the activity of total NO-synthase by 59.1%, inducible NO-synthase by 61.1%, and constitutive NO-synthase by 9% compared to the control group. The activity of ornithine decarboxylase increased by 26.5% in the brain tissues of the rats with simulated desynchronosis compared to the control group.

In conclusion, the disruption of "light-dark" cycles leads to the development of oxidative stress in brain tissues of animals and is characterized by increased production of reactive oxygen species and diminished antioxidant protection. Acute desynchronosis decreases nitric oxide production through the NO-synthase pathway, while increasing the accumulation of toxic nitric oxide metabolites in the brain tissues of rats, thereby posing a potential risk of nitrosative stress. Furthermore, alterations in the normal light regimen of the day activate the arginase pathway of L-arginine metabolism and result in increased glutamate production in the brain tissues of rats, potentially leading to oxidative stress.
MORPHOMETRICAL INDICES OF CECUM CRYPTS IN RATS UNDER INFLUENCE OF FOOD ADDITIVE COMPLEX
Authors: Kinash O.V. , Hryhorenko A.S. , Donets I.M.
Published: May 2023

Due to the widespread use of various food additives, concerns about their potential harm to the human health and their safety of approved daily intake levels in food products are increasing. One area of debate is the impact of food additives on the gastrointestinal mucous membrane. Experimental evidence has shown that the consumption of certain food additives, even within acceptable doses, can exacerbate inflammatory processes and contribute to carcinogenesis in individuals with inflammatory bowel diseases. Evaluating the functions of intestinal digestion and absorption requires considering criteria such as the number of crypts in the intestinal mucosa, their depth, structure, and the degree of cellular infiltration. Previous studies have established that the type of food and the presence of certain substances in the diet can affect the depth of crypts, the proliferative activity of crypt cells, and the number of goblet cells in the large intestine. In this study, the dynamic changes in the cecum crypt metrics of rats were analyzed over a period of 16 weeks under the influence of a complex food additive including monosodium glutamate, sodium nitrite, and ponceau 4R.

The rats of the experimental group, with access to water ad libitum, were administered with 0,6 mg/kg sodium nitrite, 20 mg/kg monosodium glutamate and 5 mg/kg ponceau 4R in 0.5 ml of distilled water once daily orally. The control group of rats (n=14) had access to drinking water without any additives and received oral saline administration. Collection of samples for histological examination was carried out at 1, 4, 8, 12 and 16 weeks.

The morphometric parameters analyzed included the number of crypts in the field of view, their depth, outer diameter, lumen diameter, and the height of epitheliocytes. The results showed that the morphometric parameters of the cecum crypts in rats changed depending on the duration of exposure to the food additive complex of monosodium glutamate, sodium nitrite, and ponceau 4R. The changes observed in the crypt structure and number indicated a significant detrimental effect of the food additive complex on the cecum mucous membrane in rats during the early stages of the experiment.

There was an incomplete recovery of the cecum crypts number and structures in the later stages of the experiment; however it occurred in the context of destructive and inflammatory changes in the mucous membrane.
GLA GENE MUTATION IN PATIENTS WITH FABRY DISEASE
Authors: Sadykhzada N. N. , Musayev Sh.Т. , Rasulov E.M.
Published: May 2023

Introduction: For the first time in the Lenkoran-Astara administrative area of Azerbaijan Republic, a genetic screening was conducted on patients with cardiomyopathies to identify Fabry metabolic disease. The screening involved the assessment of alpha-galactosidase enzyme activity and the globotriasylsphingosine level. This article aims to present the results of the screening and the subsequent molecular genetic analysis of the GLA gene in the identified patients. Materials and Methods. The genetic screening was based on applying fluorimetry and liquid chromatography methods. The Sanger sequencing technique was employed for direct sequencing of the GLA gene, enabling the detection of existing mutations. This technique was developed in CENTOGENE laboratories, Rostock, Germany. The initial tests were conducted at the Centogene laboratory in Rostock, Germany, followed by further testing at the GENOM clinical laboratory in Baku, Azerbaijan Republic. Ultrasonic and echocardiography studies were performed simultaneously with blood sampling at the central regional hospital. Results: 21 individuals out of 76 involved in the study had a deficiency in αgalactosidase enzyme activity and elevated levels of globotriasylsphingosine, indicative of Fabry disease. Among them, seven women exhibited X-linked inheritance as heterozygous, and three men were identified as homozygous. Molecular genetic analysis revealed two different mutations in the GLA gene: 801+3A>G and 137 A>G. To prevent Fabry disease, it is recommended to screen family members of affected individuals for α-galactosidase enzyme activity. Conclusion: This study represents the first genetic screening for Fabry disease conducted in the Azerbaijan Republic among patients with cardiological diseases. 21 individuals out of 76 examined patients were identified as having Fabry disease and carrying two different GLA gene mutations: c.801+3A>G and c.137A>G. The obtained genetic results will aid cardiologists to make accurate diagnosis and to select appropriate management for patients with cardiomyopathy, considering the presence of Fabry disease, as well as enabling prenatal foetus diagnostics during pregnancies in families at genetic risk.
SHAPING THE PERSONALITIES OF FUTURE DENTISTS IN PRESENT DAY CONDITIONS
Authors: Bukhanchenko O.P. , Нavryliev V.M. , Ivanytska O.S. , Boyko I.V. , Yatsenko P.I.
Published: May 2023

At present, the educational process faces new challenges that require increased effectiveness. Recent events in our country have highlighted the need to focus on fostering national self-awareness among students of high educational institutions. Education plays a critical role in the formation of future generations, making it a crucial aspect of the state policy. The Ukrainian language is an essential element of the nation's identity and a crucial factor in the formation of highly qualified specialists and loyal citizens.

The aim of this study is to analyze the influence of speech aspects on the formation of higher education students' personalities and their role in developing highly skilled professionals and patriotic citizens. The research materials and methods used in this study include exiting theoretical literature, periodicals, internet sources, statistical and analytical materials, and the authors' own research. We surveyed 120 dental students of higher medical educational establishments in order to analyze the role of language in the personality development. The results showed that 33.3% of respondents had difficulties transitioning to the Ukrainian language.

It is essential for the teaching staff of universities to encourage students to communicate fluently and permanently in their native language. By analyzing the influence of speech aspects on the personality development, it is evident that language plays a crucial role in fostering humanism, patriotism, and high professional culture in future generations. By adhering to the principles outlined in this study, it is possible to develop the personality of modern specialists as comprehensively educated individuals and patriots of Ukraine.
VISUALISATION OF HISTOLOGICAL SPECIMENS AND TASKS AS A TECHNIQUE TO IMPROVE KNOWLEDGE, SKILLS AND ABILITIES OF MEDICAL STUDENTS
Authors: Lysachenko O. D. , Shepitko V. I. , Boruta N. V. , Pelypenko L. B. , Vilkhova O. V. , Voloshina O. V.
Published: May 2023

The purpose of this study is to explore the role of visualization of histological tasks in improving the quality of knowledge, abilities, and skills of medical students by summarizing the work experience of the Department of Histology, Cytology, and Embryology.

In the field of higher medical education, the discipline of "Histology, Cytology, and Embryology" is crucial as it forms the foundation of students' understanding of the microscopic and functional morphology, structure, development, and regeneration of human cellular, tissue, and organ systems. However, first-year medical students often struggle with the vast amount of information presented to them.

To optimize the teaching of this discipline and enhance the quality of students' knowledge, modern teaching methods and technologies are employed, including the use of microscopes with video apps, multimedia projectors, and educational resources that take advantage of digital technologies. The staff of the Department of Histology, Cytology, and Embryology has also created educational resources that broaden the possibilities of digital technologies for visualization of microscopic structures: collections of photomicrographs of histological preparations and electronograms, multimedia presentations, educational films, animated videos and Internet resources (computer training programs, electronic atlases, etc.).

Students complete visualized tasks for the diagnosis of histological preparations by establishing correspondence between digital markings of structures on images of micro-samples and proposed lists of histological structures, or by diagnosing drugs through determining their colour and histological structures. These visual tasks expand the possibilities of studying histology, cytology, and embryology, eliminating randomness in assessing students' knowledge, abilities, and skills.

In practical histology classes, moulages of histological preparations, structures of human embryonic development, facial development, teeth, and their supporting apparatus, thematic stands, and wet preparations are used to enhance the visualization of histological structures.

By visualizing histological samples and tasks in practical classes, students can better assimilate educational material and acquire the skills necessary for differential diagnosis based on the analysis of microsamples. The experiences of the Department of Histology, Cytology, and Embryology can serve as an example of the positive impact of this approach on the quality of medical education.
ACADEMIC INTEGRITY AS AN IMPORTANT COMPONENT IN ENHANCING EDUCATION QUALITY
Authors: Loban G.A. , Faustova M.O. , Chumak Yu.V.
Published: May 2023

For the first time at the normative level, the concept of "academic integrity" was enshrined in the Law of Ukraine "On Education," which was adopted in 2017. Article 42 of the Law defines academic integrity as a set of ethical principles and rules that must be followed by participants in the educational process to ensure trust in the results of training and/or scientific achievements. The education quality assurance system has three structural components: the quality assurance system in educational institutions, the system of external assurance of the quality of education, and the system of quality assurance in the activities of management bodies and institutions that provide external assurance of the quality of education. The participants in the educational process who are subject to the principles of academic integrity are pedagogical, scientificpedagogical, and scientific workers, as well as students of education.

The objective of this study is to assess the level of knowledge of students at the second (Master's) level of higher education in the "Medicine" program at Poltava State Medical University regarding violations of academic integrity depending on the course of study.

Materials and methods: The study involved 117 students at the second (Master's) level of higher education in the OPP "Medicine" program at Poltava State Medical University. Among them, 73 people studied in the third year and 44 in the second year of medical faculties at the university. The study tested the students' ability to recognize various violations of academic integrity, such as plagiarism, falsification, fabrication, writing off, and deception using specific examples. Respondents were offered an anonymous questionnaire containing 10 situations regarding academic integrity issues where they had to identify violations if present. The questionnaire also included questions about respondents' demographics, such as age, gender, and year of education.

Conclusion: The majority of the surveyed secondand third-year students in the "Medicine" program at Poltava State Medical University (72.72% and 79.45%, respectively) demonstrated a sufficient or rather sufficient level of knowledge regarding violations of academic integrity.
E-COMMERCE BUMBU MASAKAN KELOMPOK TANI KWT ( KELOMPOK WANITA TANI ) SETIA DESA PAKKODI KAB. ENREKANG
Authors: Wahyuddin Wahyuddin , Alam Syahirun , Rosadi Said Imran
Published: May 2023

Advances in technology that are increasingly rapidly cannot be separated from human intervention creating sophisticated inventions. That's what makes humans can not be separated from technology, even in everyday life. Technological advances have penetrated various fields including the economic field. The internet economy encourages globalization and networking in the business world. The purpose of this research is to create an application program that can be used to make it easier to promote and sell seasoning products for loyal kwt farmer groups (women farmer groups). The research method used is a survey research method used to collect data or information about a large population using a relatively small sample and application testing using black box and white box methods, the test results are stated that the test has been successful and is free from logical function errors. This application is made using html code, javascript, php, css, and framework with My SQL database on XAMPP. The result of this research is the creation of a web-based e-commerce application so that it can facilitate the transaction process and provide broad information.
Sistem Informasi E-Farming Berbasis Web Di Kabupaten Pinrang
Authors: Masnur Masnur , Asra Asra
Published: May 2023

The purpose of writing this research is to design and build an E-Farming Information System and commodity crops. In conducting this research, researchers used an experimental method where the process begins with analyzing data requirements and developing existing systems. The initial data that you want to look for is by sharing information about this application in social media groups, both Facebook, WhatsApp and others who are domiciled in Pinrang. In addition, there is a system implementation and system maintenance, which in this case uses the PHP programming language as the backend language for this project. The results achieved from making the system with the data entered in the application using the Black Box method, it is found that the functional application runs well in accordance with the design made.
Aplikasi Perhitungan Biaya Instalasi Listrik Pada Bangunan Berbasis Android
Authors: Wafiah Andi , Setiawan Jufri Ronni
Published: May 2023

Electric power has a very important role in everyday life. The rise of the construction of new houses or buildings is accompanied by the increasing amount of electricity needed to meet these needs. Currently the development of technology is very rapid, especially Android smartphones. Therefore, to keep up with the development of science and technology that is increasingly rapidly in this era, an application is designed that can calculate the cost of electrical installations.Design Android applications are built using the Javascript and Dart programming languages​which are built using the Flutter Framework and use the Firebase database.The android application design is tested using Black Box testing which states that the system is running as needed and free from errors.Keywords : Installation, Electrical, Flutter, Visual Studio Code, Android.
APLIKASI PANDUAN PESTISIDA PADA TANAMAN PADI BERBASIS ANDROID
Authors: M. Yusuf Andi , Syamsuddin Sumantri
Published: May 2023

Rice is one of the food commodity crops that must be available. Various efforts have been made to increase rice productivity in Indonesia, one of which is agricultural intensification. with the condition that the pest population has reached its economic threshold, so this study takes the problem of the application of pesticide guides to android-based rice plants. The research method used is Field Research. The results of testing using Black Box, it is found that the functional application runs well according to the design made. While the results of the White Box test by testing the program algorithm, it is found that the number of flowgraphs with the number of paths in the white box test has the same value, namely V(G) = 6, Predicate (P) = 6 and Region (R) = 6 so it is stated that the programming logic is in accordance with the previous design.
PEMILIHAN TEMPAT KOS MENGGUNAKAN ALGORITMA SIMPLE ADDITIVE WEIGHTING DAN ALGORITMA FUZZY MULTI-ATTRIBUTE DECISION MAKING
Authors: Megah Sari Dian , Al Farisiy Salman , Arifin Nurhikma
Published: May 2023

Determination of where to live in a newly recognized area is influenced by many factors, including distance, price, facilities, room size, vehicle, house design and vehicle costs. This journal determines the criteria used in choosing a place to live. These criteria are analyzed using simple addtive weighting (saw) algorithm and fuzzy multi-attribute decision making algorithm. The results of the analysis obtained are in the form of location criteria to determine the most suitable boarding place because the presence of boarding houses around public facilities is expected for newcomers to a new area. With the advancement of information technology, it can answer the need for finding a boarding house, and will be of great help both from the side of the owner and tenant. And not only that, with this internet technology, prospective tenants can also choose a boarding house according to their wishes. Planning a system that can assist in determining temporary housing is needed by tenants in finding housing that fits the desired criteria. By making an SPK (Decision Support System) Selection of Boarding House is expected to help solve the problem of alternative housing. Therefore we need a website that makes a decision support system to determine temporary
Prototype Peternakan Ayam Broiler Berbasis Internet Of Things
Authors: Selao Ahmad , Hidayat Taufik
Published: May 2023

The purpose of making an internet-based broiler chicken prototype system is the formation of a system that can regulate the temperature of the broiler chicken coop automatically by controlling the heating device and also the fan in the closed house-based broiler chicken coop. The other goal is a system that can control the water pump on broiler farms by turning it off automatically according to the condition of the tandom whether it is full or almost empty. In this study, researchers used a descriptive method.

This internet of things based broiler farm prototype uses a DHT22 sensor to get the temperature and humidity values and also uses an ultrasonic sensor to get the water level value in the broiler farm air tank. As well as using Nodemcu ESP32 as a data processor and also using firebase cloud as a database. Based on the test, the resulting system can run well with an error rate for Ultrasonic sensors of 0.02% after 6 tests, for DHT22(temperature) sensors of 2.36% after 5 times of testing, for DHT22(humidity) sensors of 7 times. ,55% after 5 times of testing
Aplikasi Absensi Karyawan Menggunakan Geolocation Dan Finger Print Berbasis Android
Authors: Anggita Arfina Arfah  , Suwardoyo Untung
Published: May 2023

Penelitian ini bertujuan membangun suatu aplikasi absensi yang akan mencatat data dan daftar kehadiran karyawan, waktu kedatangan, waktu pulang, yang akan dibuat secara sistematis menggunakan geolocation dan finger print, serta dilengkapi fitur monitoring karyawan, sehingga admin perusahaan dapat mengetahui apabila karyawan meninggalkan lokasi perusahaan pada saat jam kerja masih berlangsung. Metode penelitian ini menggunakan metode penelitian lapangan dan Kajian Kepustakaan. Pengujian akurasi dalam fitur geolocation diuji secara manual. Hasil dari penelitian ini adalah Aplikasi Absensi Karyawan Menggunakan Geolocation dan Finger Print Berbasis Android sehingga proses pencatatan kehadiran karyawan menjadi lebih efektif dan efisien. Hasil analisis kuesioner menunjukkan bahwa 90.7% responden menyatakan aplikasi ini mudah digunakan dan 75.8% responden mengatakan absensi geolocation dan finger print berpengaruh secara positif terhadap kedisiplinan kehadiran karyawan. Hasil pengujian akurasi manual, didapatkan 7 dari 10 perangkat Android Mobile yang tingkat akurasinya tinggi sedangkan 3 lainnya lebih rendah. Sehingga didapatkan data bahwa semakin tinggi spesifikasi perangkat android mobile, maka semakin tinggi pula kemungkinan tingkat akurasi yang didapatkan.
Analisis Penerapan E-Marketing Terhadap Peningkatan Penjualan Produk Minuman
Authors: Ilham Muh , Mughaffir Mughaffir
Published: May 2023

Penelitian ini dilatarbelakangi oleh pertumbuhan perusahaan dengan produk minuman dengan pesaingnya, pertumbuhan bisnis saat ini cukup tinggi, sehingga terjadi persaingan dalam hal pangsa pasar dan konsumen. Dalam hal ini, perusahaan harus mengetahui pasar dimana produk atau jasa yang dihasilkan dipasok atau dijual. Digital marketing atau E-Marketing merupakan suatu usaha atau metode yang digunakan untuk mempromosikan produk menggunakan media digital untuk memperluas jangkauan konsumen. Dengan adanya upaya dalam menerapkan metode E-Marketing, memungkinkan perusahaan memiliki keunggulan kompetitif dengan memanfaatkan teknologi saat. Oleh karena itu penelitian ini bertujuan membuat perancangan aplikasi E-Marketing pada penjualan produk minuman Cheesetea sehingga dapat memudahkan pihak Seller dalam menganalisa peningkatan penjualan produk minuman Cheesetea dengan penerapan E-Marketing dan sistem ini juga dapat memudahkan pelanggan ketika ingin membeli produk. Hasil dari penelitian ini terlihat pada pihak admin yang bisa me monitoring semua hal secara online tanpa memeriksa langsung ke tempat. Terlihat juga pada pihak pelanggan yang dapat memudahkan dalam pemesanan secara online tanpa perlu ke tempat langsung dan menunggu pesanan disana.
Tensions Between Cuba and the USSR After the Cuban Missile Crisis: From International Politics to Political Economy
Authors: Arabadzhyan Alexandra
Published: May 2023

In this paper the author examines the contradictions between Cuba and the USSR after the Cuban Missile Crisis. The author's review of the academic literature on the subject reveals that both the conflict itself and its short-term consequences have been extensively analysed. Yet, as far as one could ascertain, there is no historiography that sheds light on the further development of the contradictions between Cuba and the USSR in the 1960s. Drawing on documents from the Soviet embassy in Cuba held in the Russian State Archive of Contemporary History, the author demonstrates that the Cuban government was still extremely concerned about its security and on several occasions even attempted to join the Warsaw Pact. Contradictions between the two countries deepened with the radicalisation of Cuban position on the international stage and the implementation of guerrilla tactics pursued by Ernesto Guevara, who also tried to implement them during his trip to Africa at the turn of 1964-1965. This is evident from the notes the revolutionary took during the trip. The document, held in the personal archive of Guevara at the Che Guevara Studies Centre in Havana, is being introduced into academic discussion for the first time. The author explores the contradictions between the USSR and Cuba over issues of socialist construction, taking as an example the economic debates in Cuba and the attempt to introduce the budgetary finance system, which was later replaced by the economic register, implying the total negation of monetary relations. The study shows that Cuban socialist construction schemes in the 1960s reflected a radical political economy approach that could not be characterised as classical “real socialism”.