bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum potassium levels and mortality of patients with acute myocardial infarction: A systematic review and meta-analysis of cohort studies
Authors: Xi Hui , Yu Rong-Hui , Wang Ning , Chen Xue-Zhi , Zhang Wen-Chao , Hong Tao
Published: January 2019

Background

The evidence of current epidemiological studies investigating the association between serum potassium levels and mortality of acute myocardial infarction (AMI) patients is controversial and inadequate.

Design

Systematic review and meta-analysis.

Methods

Two researchers independently searched the PubMed, EMBASE and Web of Science databases to identify observational studies published prior to 31 October 2017. Similarly, two researchers separately extracted data and any differences were resolved by discussion. Pooled relative risks and 95% confidence intervals (CIs) were computed with an inverse variance-weighted random-effects model. Heterogeneity among studies was assessed with the I2statistic.

Results

Seven cohort studies were included for analysis. Compared with the reference group (3.5 to <4.0 mEq/L), the pooled relative risks of mortality were 1.15 (95% CI = 1.00–1.32), 1.09 (95% CI = 0.97–1.24), 1.42 (95% CI = 1.19–1.70) and 1.85 (95% CI = 1.39–2.47) for AMI patients with a potassium level of<3.5, 4.0 to <4.5, 4.5 to <5.0, and ≥5.0 mEq/L, respectively. For admission and post-admission potassium, although J-shaped associations were also indicated, non-significant results were observed for AMI patients with potassium levels of <3.5 mEq/L when compared with the reference group. Notably, in subgroup analyses of study characteristics, stratified by study quality, geographic location, type of outcome, number of cases, type of AMI, and adjustment for potential confounders, the findings were broadly consistent across strata.

Conclusions

These findings indicate that both lower (<3.5 mEq/L) and higher (≥4.5 mEq/L) serum potassium levels are associated with an increased risk of mortality of patients with AMI.
Release of mitochondrial DNA is associated with mortality in severe acute heart failure
Authors: Krychtiuk Konstantin A , Wurm Raphael , Ruhittel Sarah , Lenz Max , Huber Kurt , Wojta Johann , Heinz Gottfried , Hülsmann Martin , Speidl Walter S
Published: January 2019

Background:

Inflammation is regarded as an important trigger for disease progression in heart failure. Particularly in severe acute heart failure, tissue hypoxia may lead to cellular damage and the release of intracellular mitochondrial DNA, which acts as an activator of the immune system due to its resemblance to bacterial DNA. It may therefore serve as a mediator of disease progression. The aim of this study was to determine circulating levels of mitochondrial DNA and its association with mortality in patients with heart failure in different presentations.

Methods:

Plasma levels of circulating mitochondrial DNA were measured in 90 consecutive patients with severe acute heart failure admitted to our medical intensive care unit as well as 109 consecutive chronic heart failure patients.

Results:

In patients admitted to our medical intensive care unit (median age 64 (49–74) years, median NT-pro-brain natriuretic peptide 4986 (1525–23,842) pg/mL, 30-day survival 64.4%), mitochondrial DNA levels were significantly higher in patients who died within 30 days after intensive care unit admission, and patients with plasma levels of mitochondrial DNA in the highest quartile had a 3.4-fold increased risk (P=0.002) of dying independent of renal function, vasopressor use and NT-pro-brain natriuretic peptide, troponin T, lactate levels or CardShock and acute physiology and chronic health evaluation II score. However, mitochondrial DNA did not provide incremental prognostic accuracy on top of the current gold standard acute physiology and chronic health evaluation II. Patients with severe acute heart failure showed significantly higher mitochondrial DNA levels (P<0.005) as compared to patients with chronic heart failure. In these patients, mitochondrial DNA levels were associated with the New York Heart Association functional class but were not associated with outcome.

Conclusions:

The release of mitochondrial DNA into the circulation is associated with mortality in patients with severe acute heart failure but not in patients with chronic heart failure. The release of mitochondrial DNA may therefore play a role within the pathophysiology of acute heart failure, which warrants further research. However, the use of mitochondrial DNA as a biomarker for risk stratification in these patients is of limited utility.
Electrocardiography changes and their significance during treatment of patients with intermediate-high and high-risk pulmonary embolism
Authors: Novicic Natasha , Dzudovic Boris , Subotic Bojana , Shalinger-Martinovic Sonja , Obradovic Slobodan
Published: January 2019

Background:

Electrocardiography (ECG) signs, typical or acute pulmonary embolism, and their changes can be used for the prediction of clinical and haemodynamic outcomes.

Purpose:

To study the predictive value of the resolution of admission ECG signs in higher risk pulmonary embolism patients for 30-day survival and for the decrease in right ventricular systolic pressure.

Methods:

We analysed the 12-lead ECGs at admission and daily for the first 5 days after hospitalisation in 110 intermediate-high and high-risk pulmonary embolism patients admitted to the intensive care unit of a single tertiary centre. The predictive value of the resolution of four ECG signs were analysed for 30-day survival and for the changes in right ventricular systolic pressure during hospitalisation: S-wave in the first standard lead, right bundle branch block pattern, S-wave in the aVL lead and negative T-waves in precordial leads.

Results:

ECG recordings showed the existence of S-wave in the I lead in 71 (64.5%), S-wave in the aVL in 77 (70%), right bundle branch block pattern in 30 (27.3%) and negative T-waves in 66 (60%) patients. All-cause 30-day in-hospital mortality was 13.6%. Among the ECG signs, only the presence of right bundle branch block at admission was significantly associated with 30-day all-cause mortality (hazard ratio (HR) adjusted for age, gender and right ventricular systolic pressure at admission was 7.7, 95% confidence interval (CI) 2.1–27.9; P=0.002). The resolution of three ECG signs during the first 5 days of hospitalisation, S-wave in the I lead (HR 26.4, 95% CI 3.1–226.6; P=0.003), S-wave in the aVL (HR 21.5, 95% CI 2.6–175.3; P=0.004) and right bundle branch block configuration (HR 5.2, 95% CI 1.3–20.8; P=0.020) were associated with 30-day survival. The intermediate-high and high-risk pulmonary embolism patients with S-wave resolution in lead aVL had 0.0% and 7.1% 30-day all-cause mortality, respectively. The patients with resolution of the S-wave in the first lead and in aVL as well as right bundle branch block had more pronounced changes in right ventricular systolic pressure at discharge (27±13 vs. 13±15 mmHg; P=0.011 for S-wave in I lead resolution, 27±12 vs. 15±17 mmHg; P=0.004 for S-wave in aVL resolution and 23±14 vs. 9±14 mmHg; P=0.040 for right bundle branch block resolution) than patients without resolution.

Conclusion:

Resolution of S-waves and right bundle branch block in ECG correlates with lower all-cause 30-day mortality in intermediate-high and high-risk pulmonary embolism patients. Resolution of S-waves in the first lead and in aVL and right bundle branch block correlates with a decrease of right ventricular systolic pressure.
Feasibility of population screening tests to establish a healthy ageing trajectory
Authors: Gordon Susan J , Grimmer Karen A , Baker Nicky , Bell Elaine , Coveney John , Jordaan Johanna H , Lind Christopher , Marin Tania , Murray Joanne , Norton Lynda H , Perimal-Lewis Lua , Sparrow Karen , Steffens Margie A , Thomas Jolene , Kidd Michael
Published: January 2019

Objectives:

There are no agreed comprehensive tests for age-related changes to physical, emotional, mental and social functioning. Research into declining function focuses on those 75 years and older and little is known about age-related changes in younger people. The aims of this project were (1) to ascertain a comprehensive test battery that could underpin community-based health screening programmes for people aged 40–75 years and pilot both (2) community-based recruitment and (3) the utility, acceptability, response burden and logistics.

Methods:

A total of 11 databases were searched using a broad range of relevant terms. An identified comprehensive, recent, high-quality systematic review of screening instruments for detection of early functional decline for community-dwelling older people identified many relevant tools; however, not all body systems were addressed. Therefore, lower hierarchy papers identified in the rapid review were included and expert panel consultation was conducted before the final test battery was agreed. Broad networks were developed in one Australian city to aid pilot recruitment of community-dwellers 40–75 years. Recruitment and testing processes were validated using feasibility testing with 12 volunteers.

Results:

The test battery captured (1) online self-reports of demographics, health status, sleep quality, distress, diet, physical activity, oral health, frailty and continence; and (2) objective tests of anthropometry; mobility; lung function; dexterity; flexibility, strength and stability; hearing; balance; cognition and memory; foot sensation; and reaction time. Recruitment and testing processes were found to be feasible.

Conclusion:

This screening approach may provide new knowledge on healthy ageing in younger people.
Desired Ageing Well: Predictive validity for consumers aged 50–80
Authors: Sengès Eloïse , Guiot Denis , Chandon Jean-Louis
Published: January 2019

Ageing well currently represents a major challenge for consumers and marketers, but this concept needs further investigation. To address this issue, we introduce the concept of Desired Ageing Well (DAW), which refers to the psychological, physical, social and financial objectives of ageing well. We provide a reliable and valid bifactor measurement model (general factor and specific factors) in which general DAW is accompanied by three specific factors, namely, physical DAW, social DAW and financial DAW. Together with age, DAW proves to be of value for explaining consumption in four sectors: e-health, cosmetic surgery, leisure and financial investment. The results obtained suggest that ageing well marketing should be developed to better design and promote products and services favouring successful ageing.
Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome
Authors: Sweetman Eiren , Ryan Margaret , Edgar Christina , MacKay Angus , Vallings Rosamund , Tate Warren
Published: January 2019

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a poorly understood disease affecting 0.2%–2% of the global population. To gain insight into the pathophysiology of ME/CFS in New Zealand, we examined the transcriptomes of peripheral blood mononuclear cells by RNA-seq analysis in a small well-characterized patient group (10 patients), with age/gender-matched healthy controls (10 control subjects). Twenty-seven gene transcripts were increased 1.5- to sixfold and six decreased three- to sixfold in the patient group ( P < 0.01). The top enhanced gene transcripts, IL8, NFΚBIA and TNFAIP3, are functionally related to inflammation, and significant changes were validated for IL8 and NFΚBIA by quantitative polymerase chain reaction (qPCR). Functional network analysis of the altered gene transcripts ( P < 0.01) detected interactions between the products related to inflammation, circadian clock function, metabolic dysregulation, cellular stress responses and mitochondrial function. Ingenuity pathway analysis ( P < 0.05) provided further insights into the dysfunctional physiology, highlighting stress and inflammation pathways. This analysis provides novel insights into the molecular changes in ME/CFS and contributes to the understanding of the pathophysiological mechanisms of the disease.
Effects of pelvic floor bioelectrical stimulation on frozen embryo transfer patients with thin endometrium
Authors: Yuan Bing , Zheng Hong , Xu Minling , Mu Xiaoli , Huang Fengcai
Published: January 2019

This study was to observe the effects of pelvic floor bioelectrical stimulation on pregnancy outcome and serum estradiol (E2) and progesterone (P) levels in frozen embryo transfer patients with thin endometrium. 120 cases frozen embryo transfer patients with thin endometrium in our hospital from March 2016 to April 2017 were selected. These patients received artificial cycle replacement plan before embryo transfer. According to whether pelvic floor bioelectrical stimulation therapy was accepted, 120 cases of thin endometrial frozen embryo transfer were divided into control group and observation group. 50 cases of the control group received artificial cycle to prepare for embryo transplantation, while 70 cases of observation group received bioelectrical stimulation as intervention treatment on the basis of artificial cycle. The intima thickness, subintimal hemodynamic parameters, embryo implantation rate, and clinical pregnancy rate were compared between the two groups before and after treatment. There was no significant difference in endometrial thickness between the two groups on the 10th day of menstruation ( P > 0.05). The thickness of endometrium and the index of intima growth in the observation group were significantly higher than those in the control group ( P < 0.05). The pulsatility index, resistance index, and systolic and diastolic blood flow velocity ratio of subintimal blood flow in the observation group were significantly higher than those in the control group ( P < 0.05). Before treatment, there was no significant difference in serum E2 and P between the two groups ( P > 0.05). After treatment, the improvement of serum E2 and P in the observation group was significantly better than that of the control group ( P < 0.05). The embryo implantation rate (25.7%) in the observation group was significantly higher than that in the control group (17.0%) ( P < 0.05). The clinical pregnancy rate (47.1%) in the observation group was significantly higher than that in the control group (30%) ( P < 0.05). In conclusion, the intervention of pelvic floor bioelectrical stimulation can improve the blood perfusion of thin endometrium, improve the endometrial receptivity, increase the implantation rate of frozen embryo transfer in patients with thin endometrium, and improve the level of serum estradiol and progesterone.
Tata Group: Trauma of Transition
Authors: Balabhaskaran P.
Published: January 2019

The case is set around the removal of Cyrus Mistry from the Chairmanship of Tata Sons Ltd, the holding company of the Tata Group. The case traces the origin and evolution of the Tata Group, the challenges of succession as experienced by the group and the emerging challenges of adapting to a new paradigm of its global existence. The case also explores the unique organization structure of the group, genesis of its value system, the reality of its suboptimal performance, and the challenges of nurturing organizational processes to ensure all-weather leadership for the changing times. The case brings into focus the social context of an organization and brings in the debate whether profit maximization is the only prime objective of an organization or whether profit maximization has to rank along with the social commitment of the organization.
Attachment and autism spectrum conditions: Exploring Mary Main’s coding notes
Authors: Coughlan Barry , Marshall-Andon Tess , Anderson Julie , Reijman Sophie , Duschinsky Robbie
Published: January 2019

Distinguishing autism spectrum behaviors from behaviors relating to disorganized attachment can be challenging. There is, for instance, a notable overlap between both conditions in terms of behaviors deemed stereotypical. In addition, there are also similarities regarding some atypical social overtures. Responding to this overlap has been the subject for much debate in the literature. Disorganized attachment was first introduced and conceptualized by the attachment researcher, Mary Main. Main is considered the leading authority on coding this phenomenon. During the course of archival research, we obtained Main’s notes on coding attachment in a group of 15 children with autism spectrum conditions (hereafter ASC). Drawing on these texts, this article explores Main’s reasoning when making distinctions between ASC and attachment at the behavioral level. Our approach is informed by Chang’s argument for the potential of “history as complementary science.” Analysis indicates that, for Main, frequency and timing were important differential factors when attributing a behavior to either ASC or the child’s attachment pattern.
CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks
Authors: Uras Iris Z. , Maurer Barbara , Nivarthi Harini , Jodl Philipp , Kollmann Karoline , Prchal-Murphy Michaela , Milosevic Feenstra Jelena D. , Zojer Markus , Lagger Sabine , Grausenburger Reinhard , Grabner Beatrice , Holly Raimund , Kavirayani Anoop , Bock Christoph , Gisslinger Heinz , Valent Peter , Kralovics Robert , Sexl Veronika
Published: January 2019

Over 80% of patients with myeloproliferative neoplasms (MPNs) harbor the acquired somatic JAK2V617F mutation. JAK inhibition is not curative and fails to induce a persistent response in most patients, illustrating the need for the development of novel therapeutic approaches. We describe a critical role for CDK6 in MPN evolution. The absence of Cdk6 ameliorates clinical symptoms and prolongs survival. The CDK6 protein interferes with 3 hallmarks of disease: besides regulating malignant stem cell quiescence, it promotes nuclear factor κB (NF-κB) signaling and contributes to cytokine production while inhibiting apoptosis. The effects are not mirrored by palbociclib, showing that the functions of CDK6 in MPN pathogenesis are largely kinase independent. Our findings thus provide a rationale for targeting CDK6 in MPN.
Successful donor engraftment and repair of the blood-brain barrier in cerebral adrenoleukodystrophy
Authors: Orchard Paul J. , Nascene David R. , Miller Weston P. , Gupta Ashish , Kenney-Jung Dan , Lund Troy C.
Published: January 2019

Adrenoleukodystrophy (ALD) is caused by mutations within the X-linked ABCD1 gene, resulting in the inability to transport acylated very long chain fatty acids (VLCFAs) into the peroxisome for degradation. VLCFAs subsequently accumulate in tissues, including the central nervous system. Up to 40% of boys develop a severe progressive demyelinating form of ALD, cerebral ALD, resulting in regions of demyelination observed on brain magnetic resonance imaging that are associated with a “garland ring” of gadolinium contrast enhancement. Gadolinium enhancement indicates blood-brain barrier (BBB) disruption and an active inflammatory disease process. Only hematopoietic cell transplant (HCT) has been shown to halt neurologic progression, although the mechanism of disease arrest is unknown. We evaluated imaging- and transplant-related biomarkers in 66 males who underwent HCT. In 77% of patients, gadolinium contrast resolved by 60 days post-HCT. We determined that time to neutrophil recovery and extent of donor chimerism correlated significantly with time to contrast resolution post-HCT. Graft failure was associated with a significantly slower rate of contrast resolution (P < .0001). Time to neutrophil recovery remained significant in multivariate analysis with other biomarkers (P = .03). Our data suggest that robust donor myeloid recovery is necessary for timely repair of the BBB.
Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning
Authors: Wang Shuo , Shi Jingyun , Ye Zhaoxiang , Dong Di , Yu Dongdong , Zhou Mu , Liu Ying , Gevaert Olivier , Wang Kun , Zhu Yongbei , Zhou Hongyu , Liu Zhenyu , Tian Jie
Published: January 2019

Epidermal growth factor receptor (EGFR) genotyping is critical for treatment guidelines such as the use of tyrosine kinase inhibitors in lung adenocarcinoma. Conventional identification of EGFR genotype requires biopsy and sequence testing which is invasive and may suffer from the difficulty of accessing tissue samples. Here, we propose a deep learning model to predict EGFR mutation status in lung adenocarcinoma using non-invasive computed tomography (CT).

We retrospectively collected data from 844 lung adenocarcinoma patients with pre-operative CT images, EGFR mutation and clinical information from two hospitals. An end-to-end deep learning model was proposed to predict the EGFR mutation status by CT scanning.

By training in 14 926 CT images, the deep learning model achieved encouraging predictive performance in both the primary cohort (n=603; AUC 0.85, 95% CI 0.83–0.88) and the independent validation cohort (n=241; AUC 0.81, 95% CI 0.79–0.83), which showed significant improvement over previous studies using hand-crafted CT features or clinical characteristics (p<0.001). The deep learning score demonstrated significant differences in EGFR-mutant and EGFR-wild type tumours (p<0.001).

Since CT is routinely used in lung cancer diagnosis, the deep learning model provides a non-invasive and easy-to-use method for EGFR mutation status prediction.
Which definition of a central tumour is more predictive of occult mediastinal metastasis in nonsmall cell lung cancer patients with radiological N0 disease?
Authors: Shin Sun Hye , Jeong Dong Young , Lee Kyung Soo , Cho Jong Ho , Choi Yong Soo , Lee Kyungjong , Um Sang-Won , Kim Hojoong , Jeong Byeong-Ho
Published: January 2019

Background

Guidelines recommend invasive mediastinal staging for centrally located tumours, even in radiological N0 nonsmall cell lung cancer (NSCLC). However, there is no uniform definition of a central tumour that is more predictive of occult mediastinal metastasis.

Methods

A total of 1337 consecutive patients with radiological N0 disease underwent invasive mediastinal staging. Tumours were categorised into central and peripheral by seven different definitions.

Results

About 7% (93 out of 1337) of patients had occult N2 disease, and they had significantly larger tumour size and more solid tumours on computed tomography. After adjustment for patient- and tumour-related characteristics, only the central tumour definition of the inner one-third of the hemithorax adopted by drawing concentric lines arising from the midline significantly predicted occult N2 disease (adjusted OR 2.13, 95% CI 1.17–3.87; p=0.013). This association was maintained after excluding patients with pure ground-glass nodules (adjusted OR 2.54, 95% CI 1.37–4.71; p=0.003) or only including those with solid tumours (adjusted OR 2.30, 95% CI 1.08–4.88; p=0.030).

Conclusions

We suggest that a central tumour should be defined using the inner one-third of the hemithorax adopted by drawing concentric lines from the midline. This is particularly useful for predicting occult N2 disease in patients with NSCLC.
Bioethics and hereditary genetic modifications
Authors: Kaludjerovic Zeljko
Published: January 2019

Significant breakthroughs in genetic research promoted by the human genome project, advances in molecular biology and new reproductive technologies have improved the understanding and the possibility of genetic interventions as a potential medication for diseases caused by differentiated disorders, especially those that originated in irregularities in individual genes. The progress achieved in contemporary studies has created the likelihood that the man has the technical capacity to modify the genes that will be transmitted to the next generations as well. These are the so-called hereditary genetic modifications, i.e. any biomedical interventions which could be expected to transform the genome which a person could transfer to their offspring. The author analyses in this paper why even the hints of transformations of genes that will be passed on to future generations cause deep bioethical, theological, legal and political debates and controversies. He also believes that in the era of rapid strengthening of the social and technical and technological effects of science, it is very important that scientists, in their perceptions and insights, which particularly in the field of humanities, do not have the character of value beliefs, do not go below the achieved civilization standards of ethical and moral culture and to reflect on different themes with due care and awareness of the dilemmas that they can encounter in their professional work. An adequate interdisciplinary, multidisciplinary and pluriperspective approach, as well as the awareness of the essential compatibility of scientific freedom and responsibility, should ultimately result in a different and more sophisticated attitude of the scientists themselves to the possibilities of their own discipline and the significance of its effects.
A quantitative analysis of sources of changes in government expenditures on health, 2000 to 2015: what can we learn from experience to date?
Authors: Saxenian Helen , Bharali Ipchita , Ogbuoji Osondu , Yamey Gavin
Published: January 2019

Background: Achieving universal health coverage (UHC) requires increased domestic financing of health by low-income countries (LICs) and middle-income countries (MICs). It is critical to understand how much governments have devoted to health from their own sources and how much growth might be realistic over time.

Methods: Using data from WHO’s Global Health Expenditure Database, we examined how the composition of current health expenditure changed by financing source and the main sources of growth in health expenditures from 2000-2015. We also disaggregated how much growth in government expenditures on health from domestic sources was due to economic growth, growth in the tax base, reallocations in government expenditures towards health, and the interactions of these factors.

Results: Lower MICs (LMICs) and upper MICs (UMICs), as a group, saw a significant reduction in out-of-pocket expenditures and a significant growth in government expenditures on health from domestic sources as a share of current health expenditures over the period. This trend indicates likely progress in the pathway to UHC. For LICs, these trends were much more muted. Growth in government expenditure on health from domestic sources was driven primarily by economic growth in LICs, LMICs, and UMICs. Growth in government expenditure on health due to a strengthened tax base was most important in UMICs. For high-income countries, where economic growth was relatively slower and tax bases were already strong, the largest driver of growth in government expenditure on health from domestic sources was reallocation of the government budget towards health.

Conclusions: Given these findings from 2000-2015, discussions about a government’s ability to reallocate to health from its overall budget need to be evidence based and pragmatic.  Dialogue on domestic resource mobilization needs to emphasize overall economic growth and growth in the tax base as well as the share of health in the government budget.
Chronotopic Narratives of Seven Gurus and Eleven Texts: A Medieval Buddhist Community of Female Tāntrikas in the Swat Valley of Pakistan
Authors: Kragh Ulrich Timme
Published: January 2019

Modern South Asian women’s writing wells up to the stirring surface of contemporary literature in now globally recognizable forms of fiction and memoir, inter alia, the novel, the poem, the biography, the autobiography. Yet, beneath these topmost layers of colonial and post-colonial literary tides flow undercurrents of precolonial women’s writing, often in radically other figurations of lettered expression. Even further down than the familiar temporal strata of the Vaiṣṇavite and Śaivite religious poetry written by the dozen authoresses ranging from Muktābāi to Rūpa Bhavānī between the thirteenth and eighteenth centuries, there exists another place in the deep, like an underwater lake, of a much older women’s writing penned by Tantric women gurus. The majority of this archaic Buddhist literature streamed out of the Swat valley in Pakistan, a locality for no less than seven known female gurus, who lived, taught, or wrote there between the eighth and eleventh centuries. After a short prologue on Swat and its recent history, the essay surveys eleven female-authored medieval Tantric works, which range in genre from ritual treatises, meditation practice-texts, and mystic poems, to literary forms that even seem evocative of contemporary women’s gendered voices: spiritual biography and autobiography empowered by a place.
A Life of the ‘Other’ and a Story of the ‘Self’: Shivarani Devi in "Premcand ghar me͂"
Authors: Chudal Alaka Atreya
Published: January 2019

This paper will deal with Shivarani Devi’s (1890–1976) Premcand ghar mẽ, a literary memoir-cum-biography of her husband Premchand, a pioneer of Hindi literature. The book has already been extensively discussed in previous studies as a mirror held up to Premchand, revealing all his dynamism as a writer, intellectual and householder. Against this backdrop, this article attempts to delve more deeply into Shivarani Devi’s own intimate space within the household. It will discuss the ‘self’ that Shivarani Devi necessarily lays bare while portraying her husband, the ‘other’. It will analyse the narrated self of Shivarani Devi within the domesticity that she defines as ghar.
Aceitar ou Rejeitar? Eis a Questão dos Tipos de Argumentos para a Justificativa de Artigos em Administração
Authors: Lukosevicius Alessandro Prudêncio , Guimarães Jairo de Carvalho , Zouain Deborah Moraes
Published: January 2019

A relevância do estudo tem sido reconhecida como principal fator de rejeição ou aceitação de artigos pelos editores de periódicos. Assim, justificar o estudo de maneira clara e persuasiva é um conhecimento preponderante para os pesquisadores. Todavia, apesar da importância, os manuais de pesquisa tratam de forma superficial a apresentação da relevância de uma pesquisa. Desse modo, o objetivo deste artigo é identificar os tipos de argumentos empregados para justificar as pesquisas científicas em Administração. Para obter a resposta, empregou-se pesquisa exploratória implementada por métodos mistos (triangulação concomitante). Como resultado, identificou-se seis tipos de argumentos empregados por artigos na área de Administração: argumentos de autoridade, escassez, contribuição teórica, necessidade, contribuição prática e lacuna.
O Uso de Jogos de Empresas em Diferentes Níveis Educacionais: Integração, Prática e Pesquisa Envolvendo Estudantes de Graduação e Pós-Graduação em Administração
Authors: Santos-Souza Humberto Reis dos , Oliveira Murilo Alvarenga
Published: January 2019

Embora a articulação entre ensino e pesquisa seja um preceito construtivo da universidade brasileira, nota-se um distanciamento entre a graduação com seu foco no ensino e a pós-graduação com seu foco na pesquisa. Considerando a potencialidade que os jogos de empresas apresentam para a formação gerencial, permitindo a prática (sob risco e incerteza controlados) e a pesquisa, dentro dos preceitos do Laboratório de Gestão, há que se considerar o uso dessa proposta metodológica em diferentes níveis educacionais com vistas à integração de graduandos e pós-graduandos. Sendo assim, o objetivo deste artigo é compreender o processo de integração entre estudantes de níveis educacionais diferentes por meio dos jogos de empresas. O estudo tem caráter qualitativo, de nível exploratório-descritivo, baseando-se na experiência da disciplina de Gestão Empresarial Simulada em um curso de pós-graduação, em uma instituição federal, na região sul do estado do Rio de Janeiro. Durante a aplicação do jogo de empresas, os estudantes da pós-graduação foram convidados a integrarem-se aos estudantes da graduação matriculados na disciplina de Laboratório de Gestão II, do curso de graduação em Administração. Após a vivência, os dados da pesquisa foram coletados por meio de entrevista semiestruturada realizada com uma amostra de estudantes e, posteriormente, analisados por análise de conteúdo. Os resultados indicam que a integração entre pós-graduação e graduação durante a vivência gerencial, permitiu a manutenção ou melhora da qualidade do aprendizado social no jogo de empresas. Indicam, também, que a articulação entre ensino e pesquisa em níveis de ensino diferentes, por meio dos jogos de empresas, pode contribuir para uma relação mais virtuosa entre graduação e pós-graduação.
Inovações e Desafios Metodológicos no Ensino de Administração Pública no Brasil: um Olhar com Base no Curso da FGV-EAESP
Authors: Santos Fernando Burgos Pimentel dos , Teixeira Marco Antonio Carvalho
Published: January 2019

Inovações e Desafios Metodológicos no Ensino de Administração Pública no Brasil: um Olhar com Base no Curso da FGV-EAESP.
A Thin Anterolateral Thigh Free Flap for Severe Hand Burn Deformity
Authors: Atmodiwirjo Parintosa , Mukarramah Dewi Aisiyah
Published: January 2019

Background: Hand is one of the most commonly involved areas in burn injury, resulting in contracture.1 Reconstruction of severe postburn hand deformity is very challenging. Because there is no adjacent skin laxity to allow for local flaps in the burned hand, distant or free flaps should be considered. 2 Application of the thin anterolateral thigh flap in hand reconstruction has become one of the most preferred options for resurfacing of soft-tissue defects after contracture release. 3 Other than closing the defect after contracture release, restoration of hand function is also essential.Patient and Methods: In 2010, a man, 37 years old presented with severe contracture on the right hand due to an explosive flame burn 1,5 years ago. On the right hand, there was hyperextension at the metacarpophalangeal (MCP) joint with flexion on the wrist and thumb abduction with hyperextension at the interphalangeal joint. Our goal is to reconstruct this severe hand burn deformity using thin ALT free flap with flap thickness 4 mm to achieved good hand contour.Results: The thin ALT free flap was vital, and 1-year follow-up gives good hand contours. Patient under rehabilitation therapy from 2 weeks postoperative to attain good functional hand.Summary: A thin anterolateral thigh free flap gives good alternative for resurfacing defect in reconstruction of burn hand than other fasciocutaneous flaps. The advantage are it provides the same color and texture, thin and pliable flap to form good hand contour.
Maxillary Growth Evaluation After Cleft Palate Repair Using Goslon Criteria: Preliminary Study
Authors: Simamora Huntal , Lamtiur Evie , A. Nur , Handayani Siti , Bangun Kristaninta
Published: January 2019

Background: The goal of palatoplasty is to achieve normal maxillofacial growth, normal speech, and prevent hearing loss. Disturbance of maxillary growth may occur in cleft lip palate patients after palatoplasty. To determine how many patients later developed a disrupted maxillary growth following operations, a retrospective study was designed to evaluate patients with complete unilateral cleft lip and palate who have undergone two-flap palatoplasty.Methods:A retrospective analytic study evaluated the maxillary growth of 15 consecutive unilateral cleft lip and palate patient aged around 8-year-old treated in the Division of Plastic Surgery Cipto Mangunkusumo Hospital, Jakarta. Cephalogram and dental study models were used to assess growth. Cleft lip and palate repair were performed to all patients without alveolar bone graft or any orthodontic treatment. Result: The cephalogram shows that 53,3% of the patients developed maxillary hypoplasia post palatoplasty. Mean value of the Goslon Yardstick was 3,53 (intermediate category by Goslon criteria).No patient fell into the Goslon 1 or 5 categories. Discussion: Disturbed maxillary growth is postulated to be caused by the manipulation and suturing of the maxillary vomer, and scarring of the dentoalveoli post-surgery. Another contributing factor is the intrinsic tissue deficiency. Conclusion: Maxillary hypoplasia is a possible complication following two !ap palatopasty, affecting either anteroposterior, transversal and vertical maxillary growth. This finding needs to be proven especially after the process of growth ceased. It is highly probable that maxillary disruption is higher when the two flap palatoplasty technique leaves lateral areas of denuded bone on the maxillary tuberosity.
Hypospadic Cripple: How To Avoid
Authors: Bisono Bisono
Published: January 2019

The term hypospadic cripple is very apt to use for hypospadic patient who has underwent several unsuccessful reconstruction attempt. The meaning of the word cripple is uncapable to function properly. If it is used for condition after failure of several attempt of reconstructions in hypospadia repair, the meaning of severe damage should apply; a crippled penis with fistula, stricture, contracture and less healthy skin cover.
Modified Radial Incision Technique in Reduction Nipple Hypertrophy
Authors: Marita Adinda , Budiman Budiman
Published: January 2019

Background: Nipple hypertrophy causes psychosocial embarrassment and discomfort to the affected individuals. The only mean to correct it is by performing surgical procedure aiming to reduce the diameter as well as the vertical height of the nipple while preserving the lactiferous ducts.
Patients and Methods: Two cases of nipple hypertrophy were described in this case series : the first one was a male patient presented with an overly prominent nipple of the left breast. Second case was a female patient with bilateral nipple hypertrophy. Circular design was performed at the tip of the nipple to match the size of the normal nipple. Three wedged excisions was made, and also three radial pillars with its pedicle divided into two parts: the lower part was de-epithelialized. This technique was able to reduce the diameter and also the vertical height of nipples without compromising their vascular supply.
Result: No complications such as nipple necrosis or sensory loss were found in both patients during follow-up period. The normal symmetry of the nipple contour was restored. Conclusion: We described a simple technique for both male and female patients with nipple hypertrophy, which provided good aesthetic result and patient satisfaction.
Modalities to Treat Penile Glans Amputation: Case Series
Authors: Sukasah Chaula L. , Atmodiwirjo Parintosa , Anindhawati Nur
Published: January 2019

Background: In Indonesia, a country with Muslim population as a majority, circumcision is the most common operation performed in males. However, since circumcisions are also commonly performed by inexperienced individuals and during communal circumcision event, we frequently come across complications. One of the most severe complications is amputation of the penile glans. There are several techniques that can be used to treat this complication. In this paper we present some which have been used in our division and the result. Patient and Methods: We report three cases of traumatic penile glans amputation as a complication of circumcision that has been admitted to Cipto Mangunkusumo Hospital during January 2011 – January 2012. In first case we performed full thickness skin graft, in the second one we performed groin flap, and scrotal flap to reconstruct the third case. We evaluate the result for several months. Results: The three techniques showed no complication, good result in function and also aesthetically acceptable for patient and the family. Choice of technique that has been used to repair the amputated penis depended on the patient condition, and surgeon’s choice.Summary: The three techniques each has advantages and disadvantages, but all of them are acceptable, functionally and aesthetically.
Study of allergenic and locally irritant action of preparation “Eferol, spray”
Authors: Romanova M. , Dairov A. , Seidakhmetova R. , Shnaukshta V. , Adekenov S.
Published: January 2019

The aim of this study was a research of the allergenic and locally irritating effect of the drug "Eferol spray". Methods. Possible allergenic and locally irritating effect was studied using the method of skin application, on the model of "general anaphylaxis reaction (anaphylactic shock)", on the model of "conjunctival sample", as well as using indirect test degranulation of mast cells. Results. It was noted the presence of study drug "Eferol, spray” certain allergenic potential, identified in the study of allergenic effect on the model of "general anaphylaxis reaction". It was found the ability of the researched drug to induce delayed hypersensitivity reaction with repeated enteral introduction. The drug "Eferol spray" does not have skin sensibility activity in the study by cutaneous applications and conjunctival samples.
Onychomycosis: local pharmacokinetics and the future of topical antifungals
Authors: Sergeev A. , Burtseva G. , Sergeev V.
Published: January 2019

Topical treatment for onychomycosis gains momentum in dermatological practice as well as in antifungal formulations research pipeline. Decades of clinical use of internationally available antifungals bring no consensus on real clinical efficacy of topical monotherapy of fungal nail infection. Recommendations of national societies and expert bodies offer no clear guidance on principles and practice of combination therapy with systemic and topical antifungals. Clinical trials conducted to date indicate evidence-based superiority of naftifine 1% topical formulations in management of tinea pedis and onychomycosis. Recently, Russian and international authors evaluated the benefits of antifungal solutions in treatment of onychomycosis. New data on pathophysiology of fungal nail infection and local pharmacokinetics of drugs inside the affected nail elucidate the success of 1% solution of naftifine in topical treatment of onychomycosis.
Fabric Surface Characteristics and their Impact on Digital Textile Printing Quality of PET Fabrics
Authors: Lim Jihye , Chapman Lisa Parrillo
Published: January 2019

Pretreatment and yarn type alter the characteristics of fabric surfaces and impact the quality of inkjet digital printing including colorfastness, color shade, colorfulness, and color strength. Specifically, printed pigments are subject to crocking due to physical attachment on a fiber surface without diffusing into the fibers, which increases color transfer to another fabric. This remains a challenge in obtaining high colorfastness as well as full color shade, colorfulness, and color strength. Thus, this study investigated and quantitatively analyzed the effects of pretreatment and yarn type on shade, colorfulness, color strength, and crockfastness. Fabric wettability was also observed to examine the impact on printing quality.
Fuzzy Modelling for Prediction of Bursting Strength of Knitted Cotton Fabric using Bleaching Process Variables
Authors: Haque Abu Naser Md. Ahsanul , Smriti Shamima Akter , Farzana Nawshin , Siddiqa Fahmida , Islam Md. Azharul
Published: January 2019

A fuzzy prediction model has been built based on hydrogen peroxide concentration, bleaching temperature, and time of bleaching as the input variables and knitted cotton fabric bursting strength as the output variable. Fuzzy expert systems can map efficiently in nonlinear domains with minimal experimental data. The model developed in the present study has been validated by new experimental data. The root mean square, mean absolute error percentage, and coefficient of determination ( R 2 ) between the predicted and experimental values were found to be 4.89, 0.707, and 0.965 respectively. The results confirm that the model can be applied successfully for the prediction of fabric bursting strength in textile dye houses.
Relasi Kualitas Batubara dengan Lingkungan Pengendapan Pit South Pinang dan Sekitarnya, PT. Kaltim Prima Coal, Sangatta Utara, Kutai Timur, Kalimantan Timur
Authors: Aditama Givandi , Pudjihardjo Henarno , Hidayatillah Ahmad Syauqi
Published: January 2019

Total sulfur adalah salah satu parameter untuk menentukan kualitas batubara, dan tinggi rendahnya nilai total sulfur salah satunya dipengaruhi oleh lingkungan pengendapan batuan pengapit serta batubara itu sendiri. Abu dalam batubara merupakan material pengotor yang tersisa setelah proses pembakaran, sehingga keterdapatan abu dapat menurunkan kualitas batubara. Penelitian ini dilaksanakan pada area Pit South Pinang dan sekitarnya yang tersusun dari Formasi Balikpapan. Observasi lapangan serta Measuring Stratigraphy (MS) dilakukan untuk mengetahui kondisi geologi daerah penelitian. Properti batubara, yang diketahui berdasarkan hasil analisis proksimat dan ultimat dari sampel sumur bor, menjadi parameter yang dianalisis untuk menginterpretasikan lingkungan pengendapan batubara di daerah penelitian. Dijumpai empat satuan litologi pada daerah penelitian dari yang tertua hingga yang termuda yaitu Satuan Batulempung Karbonan Sisipan Batugamping, Satuan Batulempung Sisipan Batupasir-Batubara, Satuan Batupasir Sisipan Batulanau dan Dataran Aluvial. Berdasarkan data yang diperoleh di lapangan, dapat diinterpretasikan bahwa satuan pembawa batubara, yaitu Satuan Batulempung Sisipan Batupasir-Batubara terendapkan pada lingkungan Transitional Lower Delta Plain. Batubara pada daerah penelitian berdasarkan ASTM D388-99 diklasifikasikan sebagai High Volatile C Bituminous Coal. Berdasarkan hubungan antara kondisi geologi dengan nilai total sulfur dan abu yang terdapat pada Pit South Pinang, lingkungan pengendapan cukup berpengaruh terhadap nilai total sulfur dan abu, semakin besar pengaruh air laut, nilai total sulfur dan abu menjadi lebih tinggi.
Geokimia Daerah Panasbumi Gunung Pandan, Kabupaten Bojonegoro, Jawa Timur
Authors: Ramadhani Hanindya , Wijayanti Herning Dyah Kusuma , Trisnaning Paramitha Tedja
Published: January 2019

Pulau Jawa memiliki potensi sumberdaya panasbumi yang tinggi, dibuktikan dengan se-kitar 70% jumlah lapangan panasbumi yang telah beroperasi di Indonesia terletak di Pulau Jawa. Sebagian besar prospek yang telah diidentifikasi berasosiasi dengan gunungapi, khususnya yang berumur Kuarter. Eksplorasi dan eksploitasi panasbumi di Pulau Jawa, hingga saat ini banyak berfokus di Jawa Tengah dan di bagian timur Jawa Barat. Minimnya penyelidikan panasbumi di daerah Jawa Timur menyebabkan kurangnya informasi mengenai sistem panasbumi di wilayah ini. Gunung Pandan merupakan salah satu gunungapi yang terletak di wilayah Kabupaten Bojonegoro, Provinsi Jawa Timur. Kehadiran manifestasi mataair panas dan kolam lumpur menjadi salah satu indikasi prospek energi panasbumi. Penelitian terhadap kehadiran manifestasi panasbumi dapat menjadi referensi dalam melakukan penyelidikan detail potensi panasbumi di daerah ini. Pengamatan geologi lapangan dan pengambilan sampel air pada lokasi mataair panas dan kolam lumpur mencakup koordinat dan ketinggian lokasi pengambilan sampel, jenis litologi, serta temperatur dan pH manifestasi. Sampel air diuji di laboratorium guna mengetahui kandungan unsur kimianya, selanjutnya dilakukan analisis terkait tipe fluida dan geotermometer. Daerah Gunung Pandan, terutama pada setiap lokasi penyelidikan, tertutup endapan limonit dan sebagian lokasi dijumpai adanya travertine. Hasil analisis menunjukkan fluida di ke empat daerah memiliki tipe Sodium Klorida yang dicirikan dengan kandungan Na + K dan Cl yang tinggi, serta memiliki sifat air dewasa. Hasil analisis geothermometer, diperkirakan temperatur terendah reservoir sebesar 153° C dan temperatur tertinggi reservoir sebesar 222°C.