bluuebunny/crossref_metadata_2025 huggingface dataset:
SURGICAL TREATMENT OF ISOLATED ASEPTIC ACETABULAR LOOSENING IN PATIENTS WITH STABLE FEMORAL COMPONENT
Authors: Markov D. A. , Zvereva K. P. , Sertakova A. V. , Belonogov V. N. , Troshkin A. Yu.
Published: July 2018

Background: Aseptic acetabular loosening currently occupies the 1st place in the structure of delayed complications after total hip arthroplasty. The basis of treatment is the replacement of a loosening cup and a pair of friction. The tactics of surgical treatment of the stable correctly oriented femoral component have not been determined, thoroughly which confirms the relevance of the study.Aims: Compare the effectiveness of total hip revision and isolated acetabular revision in patients with aseptic acetabular loosening and stable correctly oriented femoral component.Materials and methods: The study presented the results of surgical treatment performed in 44 patients (45 revisions) with isolated aseptic acetabular loosening and stable correctly oriented femoral component were presented, Patients were divided into two groups depending on the severity of surgery. The first group included 16 patients with a total revision due to irregular cone of the stem. The second group included 28 patients (29 revisions) with an isolated replacement of the unstable cup and a pair of friction.Results: In the 1st group, revision surgery was performed to replace both cup with the friction pair and stable correctly oriented stem which finally results in lower postoperative red blood counts (erythrocytes, hemoglobin, hematocrit), as well as higher intraoperative blood loss volume and longer duration of surgical intervention if compare to the 2nd group where the stable correctly oriented femoral component was not changed. Postoperative results assessed using Harris scales and Oxford Hip Score in the comparison group were at a higher level during the whole period of follow-up. A moderate coorelation between the severity of the revision intervention and its results was detected.Conclusions: Preservation of a stable correctly oriented stem allows to reduce the severity of the revision intervention which improves the results and shortens the period of patient rehabilitation.
CHANGE MANAGEMENT OF DRUG PRODUCTS REGISTRATION CONDITIONS: NEW ICH Q12 GUIDELINE
Authors: Meshkovskii A. P. , Pyatigorskaya N. V. , Beregovykh V. V. , Aladysheva Zh. I. , Belyaev V. V. , Pyatigorsky A. M. , Ivashechkova N. S.
Published: July 2018

Introduction of amendments to the registration dossier is the responsibility of the marketing application holder (MAH). Increased knowledge on pharmaceuticals, its manufacturing and control processes can reduce the number of documents submitted to the regulatory authorities. The existing requirements establishing the procedure for the introduction of amendments differ in terms of change classification, period of notification of regulatory authorities, ways of conformity validation of pharmaceutical properties, etc. ICH proposed draft guideline Q12 «Technical and Regulatory Considerations for Pharmaceutical Product Lifecycle Management» which covers the problem of harmonization of regulatory approaches to the changes provided in the «Quality» section of CTD during the commercial phase of drug life cycle. The new guideline can be considered as the continuation and elaboration of previous ICH documents. The article provides explanations on the main provisions and regulatory mechanisms introduced by the draft guideline ICH Q12: categorization of post-approval changes, established conditions, post-approval change management protocol, and drug product lifecycle management.
Field trial of a membraneless vacuum preloading system for soft soil improvement
Authors: Lam Kok Pang , Wu Shifan , Chu Jian
Published: July 2018

This paper reports a field trial of membraneless vacuum preloading and fill surcharge to improve a compressible clay layer below sand fill at a reclaimed land site in Singapore. The thickness of the soft clay layer varied from 4 to 17 m. Due to the sand fill, a vacuum was applied to the clay layer using a proprietary membraneless method. Four weeks after the vacuum load was applied, a 2·5 m thick layer of sand fill was added as surcharge. Ground settlements, settlements and pore pressures at different depths in the soil were measured during the soil improvement. The measured field settlements and pore-pressure data were used to compute the degree of consolidation. The calculated values were found to differ considerably, the reasons for which are discussed. Experiences and lessons learned from the project are also highlighted.
Application of shakedown theory in track substructure design
Authors: Liu Shu , Wang Juan
Published: July 2018

Tracks require high performance of earth structures against excessive residual settlement under repeated train loads. In the current design standards, the quality of soil materials and compaction control are strictly prescribed based on empirical knowledge and scale tests; however, construction costs become relatively high accordingly. A more rational design method based on shakedown theory is presented here. This method makes use of the lower-bound shakedown theorem and models the soils as Mohr–Coulomb materials. By calculating the analytical load-induced dynamic elastic stress field in a three-dimensional half-space and introducing a self-equilibrated residual stress field, the maximum magnitude of surface pressure on the soil foundation (i.e. shakedown limit) against long-term residual settlement is calculated through an optimisation programme. It is found the shakedown limit is dependent on the ratio of train velocity to shear wave velocity for a given earth structure. The maximum admissible train loads for the cases with different design velocities can be predicted by modifying the quasi-static shakedown limit with an attenuation factor.
DNA Barcoding of Aristolochia Plants and Development of Species-Specific Multiplex PCR to Aid HPTLC in Ascertainment of Aristolochia Herbal Materials v2
Authors: Dechbumroong Piroonrat , Aumnouypol Surattana , Denduangboripant Jessada , Sukrong Suchada
Published: July 2018

The anecdotal evidence is outstanding on the uses of Aristolochia plants as traditional medicines and dietary supplements in many regions of the world. However, herbal materials derived from Aristolochia species have been identified as potent human carcinogens since the first case of severe renal disease after ingesting these herbal preparations. Any products containing Aristolochia species have thus been banned on many continents, including Europe, America and Asia. Therefore, the development of a method to identify these herbs is critically needed for customer safety. The present study evaluated DNA barcoding of the rbcL, matK, ITS2 and trnH-psbA regions among eleven Aristolochia species collected in Thailand. Polymorphic sites were observed in all four DNA loci. Among those eleven Aristolochia species, three species (A. pierrei, A. tagala and A. pothieri) are used as herbal materials in Thai folk medicine, namely, in Thai “Krai-Krue”. “Krai-Krue” herbs are interchangeably used as an admixture in Thai traditional remedies without specific knowledge of their identities. A species-specific multiplex PCR based on nucleotide polymorphisms in the ITS2 region was developed as an identification tool to differentiate these three Aristolochia species and to supplement the HPTLC pattern in clarifying the origins of herbal materials. The combination of multiplex PCR and HPTLC profiling achieves accurate herbal identification with the goal of protecting consumers from the health risks associated with product substitution and contamination.
Mitochondrial viability v2
Authors: Maciel de Oliveira Karen
Published: July 2018

Mitochondrial viability is determined through 2,3,5-triphenyltetrazolium chloride (TTC) conversion to insoluble formazan. TTC reduction depends on the mitochondrial respiratory activity and is proportional to the number of viable cells.
A review of the PD-1/PD-l1 checkpoint in bladder cancer: from mediator of immune escape to target for treatment
Authors: Gorelov Andrey I , Simbirtsev Andrei S , Zhuravskii Dmitrii A , Gorelova Anna A
Published: July 2018

Treatment of bladder cancer has evolved over time to include the traditional modalities of chemotherapy and surgery, and it has been greatly impacted by the use of immunotherapy. Modern immunotherapy focuses on checkpoint protein inhibitors, which are molecules impeding immune function, thereby allowing unregulated tumor cell growth and proliferation. Several immune checkpoint targets (programmed death ligand-1 [PD-L1], programmed cell death protein-1 [PD-1], and cytotoxic T-lymphocyte-associated protein 4 [CTLA-4]) have received the most attention in the treatment of bladder cancer, whereas inhibitor agents have either been approved or are in late-stage development. This review describes the most recent data on PD-L1-inhibiting agents, found on the surface of tumor cells, and PD-1, found on activated T and B cells and macrophages. Aim. A review of modern PD-1 and PD-L1 inhibitors as target immunotherapeutic agents for the treatment of bladder cancer. Materials and methods. We performed a comprehensive literature review using MEDLINE/PubMed and EMBASE. Results. The PD-1/PD-L1 pathway is possibly manipulated by cancer cells to suppress the immune system. PD-1/PD-L1 blockade has been tested in clinical trials for various malignancies, including metastatic urothelial carcinoma, with significant response rates and limited adverse effects. PD-L1 expression has mixed results as a prognostic marker for bladder cancer. Conclusions. PD-1 is a key receptor mediating immune escape, and agents targeting its ligand, PD-L1, have already been successful in patients with metastatic urothelial cancer. Further research is warranted to standardize the criteria for PD-L1 positivity and to optimize its use in the treatment of bladder cancer. (For citation: Gorelov AI, Simbirtsev AS, Zhuravskiy DA, Gorelova AA. A review of the PD-1/PD-l1 checkpoint in bladder cancer: from mediator of immune escape to target for treatment. Urologicheskie vedomosti. 2018;8(2):64-72. doi: 10.17816/uroved8264-72).
ETOS KERJA DALAM EKONOMI GLOBAL (KASUS MASYARAKAT MUSLIM MELAYU PALEMBANG)
Authors: Ritawati Raden Ayu
Published: July 2018

The purpose of this research is to know the influence of Malay and Islam in shaping the social character of Palembang Malay workers in global economic development. The Islamic economic norms embedded and rooted in the local social identity of the local Malays are the key determinants of evaluative aspects of a judging nature.

This research departs from the reason as Ushul Fiqih's written adage says "Al-Muhafazhatu'alal 'qadimis salih wal-akhdzu bil jadidil ashlah" which means "Maintaining a good old value and seeking new value better.” Field research with the participation of observations and in-depth interviews uses a qualitative approach. Respondents in this study are Palembang original Malay Muslim community, spread over 14 districts using random sampling technique. While the method of data analysis is cyclical of three stages: data collection, data display and data verification.           The results of this study prove that excessive material competition in the global economy has resulted in an anomic Palembang Malay society. Achievements in the economic field, it turns out to have transformed Palembang Malay people into a generation that is uprooted from values, fragile from the spiritual aspect, give up easily and lose socio-economic footing. The relationship of Malayness and Islamism obscures the role and competitiveness of Palembang Malay Muslims themselves in the global economic arena.
Subsídios para o gerenciamento integrado de Resíduos Sólidos Urbanos no município de São João da Barra – RJ
Authors: Berto Daniela Da Silva
Published: July 2018

Cerca de 60% dos municípios brasileiros, principalmente os de pequeno porte, ainda dispõem seus resíduos sólidos urbanos de maneira inadequada. A solução desse problema representa um grande desafio para a gestão pública. Em São João da Barra, município localizado ao norte do Estado do Rio de Janeiro, até os anos setenta, os cidadãos costumavam lançar seus dejetos diretamente nas águas do Rio Paraíba do Sul ou descartá-los a céu aberto. Em virtude disso, a investigação proposta neste trabalho tem o objetivo de fazer um diagnóstico do processo de gestão dos resíduos sólidos urbanos no município, a partir da visão de atores sociais envolvidos nesse processo. Trata-se de uma pesquisa exploratória de caráter descritivo do processo de coleta e disposição final de resíduos sólidos urbanos no município de São João da Barra/RJ. Os dados utilizados para este artigo foram obtidos por meio de bibliografia especializada, entrevista semiestruturada aplicada aos secretários de meio ambiente da Secretaria Municipal de Meio Ambiente da Prefeitura Municipal de São João da Barra e de entrevistas feitas com técnica em meio ambiente da empresa concessionária responsável pelo manejo dos resíduos urbanos no município. Ainda foram feitas visitas e observações in loco ao “lixão”, as quais permitiram descrever os aspectos inerentes à coleta, ao transporte e à disposição final dos resíduos sólidos do município em estudo. Conclui-se que o município possui sistema de coleta diário, transporte através de caminhão compactador e disposição final, porém percebeu-se que falta à comunidade a pré-disposição em tratar e minimizar a geração dos resíduos na fonte e também falta aos indivíduos a consciência dos prejuízos que os resíduos causam ao meio em que vivem. Como recomendações para estudos futuros, sugere-se que o governo municipal elabore um plano de gerenciamento integrado de resíduos sólidos, o estudo de áreas para a implantação de um aterro sanitário e a elaboração de leis que complementem o Plano Diretor existente com o assunto em questão, além de incentivar a coleta seletiva mediante programas de educação ambiental junto aos cidadãos.
Aplicação de águas residuárias em solos cultivados: atributos químicos e físicos
Authors: Souza William Luiz de , Cidrini Iorrano Andrade , Almeida Neto Onofre Barroca de
Published: July 2018

Esta revisão tem por objetivo demonstrar a utilização de águas residuárias no solo, mostrando as controvérsias e limitações dessa aplicação. Em virtude de práticas inadequadas as quais proporcionam perdas de matéria orgânica e consequentes alterações nas propriedades físicas, químicas e biológicas do solo, sua reduzida fertilidade tem sido estudada. Desse modo, a aplicação de águas residuárias de forma indiscriminada e sem critérios pode constituir um fator negativo, levando à degradação da estrutura do solo e causando desequilíbrios ambientais. Por outro lado, a administração de águas residuárias em culturas pode promover uma maior produção evitando, assim, custo com adubação mineral, e promovendo melhorias nas condições químicas e físicas do solo.
The LinkVan Project: Participatory Technology Design in Vancouver
Authors: Smythe Suzanne , Pelan Dionne , Breshears Sherry
Published: July 2018

This article tells the story of “LinkVan,” a project that explores approaches to participatory technology design to forge more equitable digital and social relations in the Downtown Eastside (DTES) community of Vancouver, British Columbia. LinkVan began as a project to create a literacy-friendly online service directory for low-income and homeless citizens. We trace the experiences and patterns of digital inequality that led to the formation of the project and describe the evolving approach to technology design oriented to “the direct involvement of people in the co-design of the technologies they use” (Simonsen & Robertson, 2013 p. 2). We consider insights from 58 user experience interviews that suggest the precariousness of access, the centrality of digital literacy education in participatory technology design, and the potential of side-by-side ‘conversations at the interface’ (Attar, 2005; Barbatsis, Comacho, & Jackson, 2004) to imagine new digital landscapes and new social relations.
Social Class and The Unequal Digital Literacies of Youth
Authors: Darvin Ron
Published: July 2018

Recognizing the importance of technology to achieve agentive participation in the knowledge economy, this paper examines to what extent social class differences between youth shape their digital literacies. Drawing on a case study of adolescents of contrasting social positions, it discusses how the material and relational differences of home environments, manifested by spatial configurations, parental involvement and peer networks, can help develop diverse practices and dispositions towards technology. By demonstrating how the inequities of digital use can lead to the unequal accumulation of cultural and social capital, this paper concludes with the educational implications of the third digital divide.
El compromiso en la teoría crítica: un análisis de tres textos de Horkheimer
Authors: Fraga Eugenia
Published: July 2018

En el presente trabajo analizaremos tres textos clave de la obra de Horkheimer (“Montaigne y la función del escepticismo”, “La función social de la filosofía”, y Dialéctica de la ilustración), intentando rastrear en ellos el concepto de compromiso entendido como elemento fundamental de la teoría crítica para las ciencias sociales. Al hacerlo, hallaremos ecos de la perspectiva de Marx, e interpretaremos al compromiso como un posicionamiento que se distancia tanto del relativismo como del dogmatismo.
Janela de oportunidade mediada: das mudanças no ânimo das demonstrações de rua ao ativismo on-line
Authors: Santos Larissa Galdino de Magalhães
Published: July 2018

O artigo propõe reflexões sobre as estruturas, oportunidades políticas e novas formas de ativismo, manifestas com do Ciclo de Confrontos iniciado nas Jornadas de Junho em 2013. As ações do Movimento Passe Livre perante o aumento da passagem do transporte público na cidade de São Paulo, desencadearam forte repressão da Polícia Militar sobre os manifestantes nas ruas e nas redes. Uma nova dinâmica ativista e de interação entre diversos atores nas redes sociais surge como oportunidade política mediada. O artigo analisa a atuação do governo municipal e Estadual de São Paulo e subsequentes eventos, como janela de oportunidade de mediação reforçada pela nova performance dos atores, manifestantes e autoridades, sendo a internet palco de construção e disputa de discursos e ativismo.
O campo recente de estudos sobre os movimentos sociais no Brasil: um balanço crítico a partir dos conceitos de permeabilidade estatal e repertórios.
Authors: Menezes Diego Matheus Oliveira de
Published: July 2018

Este artigo consiste em um balanço crítico sobre as contribuições, avanços e limitações de dois conceitos chaves presentes nas análises sobre movimentos sociais no Brasil: a permeabilidade da esfera estatal e o conceito de repertórios. A partir da análise crítica da literatura sobre o referido campo de estudos, argumenta-se a pertinência e urgência de analisar como repertórios formados por práticas tão diversificadas se transformam e desafiam as barreiras impostas pelas assimetrias na permeabilidade.
Visibilizar, sensibilizar, engajar: atuação de Brokers nos processos de resistência ao pré-sal no estado do Espírito Santo
Authors: Castro Julia Silva de
Published: July 2018

Partindo das atuais discussões acerca das mobilizações em torno dos impactos de atividades extrativistas na América Latina, busca-se compreender o processo de contestação dos afetados pela indústria do petróleo e gás no estado do Espírito Santo, tendo em vista as intermediações entre o local e o global. Diferentes valorações e práticas estão envolvidas no processo de mobilização e, nesse sentido, o intercâmbio de afetados, enquanto a materialização de uma performance constituída através de um ator “glocal”, ou broker, irá forjar uma vivência capaz de vincular demandas locais com enquadramentos que possuam projeção global.
The Bonner Place (41AG3) and J. A. Jordan (41AG5) Sites in the Neches River Basin, Angelina County, Texas
Authors: Perttula Timothy
Published: July 2018

The Bonner Place (41AG3) and J. A. Jordan (41AG5) sites are ancestral Caddo habitation sites recorded by Gus E. Arnold in November 1939 during his WPA-sponsored archaeological survey of East Texas. Both sites are in the Crawford Creek drainage; Crawford Creek is a westward-flowing tributary of the Neches River (Figure 1).
Ancestral Caddo Ceramic Sherds from 2016 Investigations at 41MR211, Marion County, Texas
Authors: Perttula Timothy
Published: July 2018

Renewed archaeological investigations in 2016 by the Texas Historical Commission at the early 19th century Caddo site 41MR211 recovered a small number of ancestral Caddo ceramic vessel sherds from a variety of contexts in Locus 3 (Table 1), which is located just east of the main 1999 excavation block (Figure 1). The sherds are from grog-tempered (70 percent) and shell-tempered (30 percent) vessels. In the larger vessel sherd assemblage (n=368) reported by Parsons et al. (2002a, 2002b) from 41MR211, 36.8 percent of the sherds are from shell-tempered vessels and 59.4 percent are from vessels made with grog temper.
Continued Shovel Test Investigations at the Historic Caddo Allen Phase Bowles Creek Site (41CE475), Cherokee County, Texas
Authors: Perttula Timothy , Stingley Kevin
Published: July 2018

The Bowles Creek site (41CE475) on Bowles Creek in the Neches River basin in East Texas (Figure 1) is an important and well-preserved Historic Caddo Allen phase habitation site on a low alluvial rise not far north of the current channel of Bowles Creek (Perttula and Stingley 2016, 2017; Perttula et al. 2016). This article summarizes the archaeological findings from the February 2016 excavation of 18 additional shovel tests (ST 40-48 and ST 50-60) at the site, placed between 10-25 m north of the Bowles Creek channel, and excavated in an attempt to clarify the subsurface character and depth of the archaeological deposits in this part of the site given the recovery of ancestral Caddo sherds from 100-140 cm bs in the Bowles Creek cut bank (Perttula and Stingley 2017).
Aflibercept: side effects in focus
Authors: Fedyanin M. Yu.
Published: July 2018

A new anti-angiogenic drug aflibercept has been authorized as a second-line therapy in patients with metastatic colon cancer. The use of this drug as part of FOLFIRI regimen significantly reduces the risk of disease progression (RR = 0.758, p = 0.00007). At the same time, the additional use of aflibercept in the VELOUR study led to the development of side effects of 3-4 degrees of severity in 83.5% of patients. In this case, the use of aflibercept in combination with FOLFIRI is not only associated with complications that are typical for anti-angiogenic drugs, but also with a high percentage of cases of diarrhea and neutropenia. In this regard, the oncologist should understand the pathogenesis, the methods for prevention and treatment of complications associated with the use of aflibercept. These particular aspects are highlighted is this review.
Migraine: Genetic Variants and Clinical Phenotypes
Authors: Rainero Innocenzo , Vacca Alessandro , Govone Flora , Gai Annalisa , Pinessi Lorenzo , Rubino Elisa
Published: July 2018

Migraine is a common, chronic neurovascular disorder caused by a complex interaction between genetic and environmental risk factors. In the last two decades, molecular genetics of migraine have been intensively investigated. In a few cases, migraine is transmitted as a monogenic disorder, and the disease phenotype cosegregates with mutations in different genes like CACNA1A, ATP1A2, SCN1A, KCNK18, and NOTCH3. In the common forms of migraine, candidate genes as well as genome-wide association studies have shown that a large number of genetic variants may increase the risk of developing migraine. At present, few studies investigated the genotype-phenotype correlation in patients with migraine. The purpose of this review was to discuss recent studies investigating the relationship between different genetic variants and the clinical characteristics of migraine. Analysis of genotype-phenotype correlations in migraineurs is complicated by several confounding factors and, to date, only polymorphisms of the MTHFR gene have been shown to have an effect on migraine phenotype. Additional genomic studies and network analyses are needed to clarify the complex pathways underlying migraine and its clinical phenotypes.
Genetic Polymorphisms within Interferon-λ Region and Interferon-λ3 in the Human Pathophysiology: Their Contribution to Outcome, Treatment, and Prevention of Infections with Hepatotropic Viruses
Authors: Grzegorzewska Alicja E.
Published: July 2018

:

Genetic polymorphisms within the interferon λ (IFN-λ) chromosomal region, mainly rs12979860 of IFN-λ4 gene (IFNL4), are known as associated with spontaneous hepatitis C virus (HCV) resolution and sustained viral response to therapy with pegylated interferon- α and ribavirin. Strong linkage disequilibrium of IFNL4 rs12979860 with IFNL4 rs368234815, which is casually associated with HCV spontaneous and therapeutical eradication, at least partially explains favorable HCV outcomes attributed to major homozygosity in rs12979860. Effects of IFN-based antiviral treatment are associated with pretreatment expression of the IFN-λ1 receptor, expression of hepatic IFN-stimulated genes, production of IFN- λ4, and preactivation of the JAK-STAT signaling. Nowadays direct-acting antivirals (DAAs) became a potent tool in the treatment of hepatitis C, but IFN-λs are still under investigation as potential antivirals and might be an option in HCV infection (DAA resistance, recurrent viremia, adverse effects).

:

Patients with altered immunocompetence are especially prone to infections. In uremic subjects, polymorphisms within the IFN-λ chromosomal region associate with spontaneous HCV clearance, similarly like in the non-uremic population. Circulating IFN-λ3 shows a positive correlation with plasma titers of antibodies to surface antigen of hepatitis B virus (anti-HBs), which are crucial for protection against hepatitis B virus. More efficient anti-HBs production in the presence of higher IFN-λ3 levels might occur due to IFN-λ3-induced regulation of indoleamine 2,3-dioxygenase (IDO) expression. IFN-stimulated response element is a part of IDO gene promoter. It is worth further investigation whether IDO gene, circulating IDO, genetic polymorphisms within the IFN-λ region, and circulating IFN-λ3 act in concordance in immunological response to hepatotropic viruses.
Drug Target Interplay: A Network-based Analysis of Human Diseases and the Drug Targets
Authors: Jain Bhushan , Raj Utkarsh , Varadwaj Pritish Kumar
Published: July 2018

Screening and identifying a disease-specific novel drug target is the first step towards a
rational drug designing approach. Due to the advent of high throughput data generation techniques, the
protein search space has now exceeded 24,500 human protein coding genes, which encodes approximately
1804proteins. This work aims at mining out the relationship between target proteins, drugs, and
diseases genes through a network-based systems biology approach. A network of all FDA approved
drugs, along with their targets were utilized to construct the proposed Drug Target (DT) network.
Further, the experimental drugs were mapped into the DT network to infer the functional relationship by
utilizing the respective network attributes. Similar to the DT network, a network of disease genes was
created through OMIM Gene Map and Morbid Map, to link the binary associations of disorder-disease
genes. In the proposed model of Human Interactome Network, shortest path length between the target
protein and disease gene was used to infer the correlation between ‘Drug Targets’ and ‘Disease-Gene’.
This network-based study will help researchers to analyze, infer and identify disease-specific novel drug
targets through harnessing the graph theory based network attributes.
Transplantation of Adipose Tissue-Derived Stem Cells into Brain Through Cerebrospinal Fluid in Rat Models: Protocol Development and Initial Outcome Data
Authors: Amini Naser , Vousooghi Nasim , Alizade Akram , Ramezani Sara , Joghataei Mohammad T. , Milan Peiman Brouki , Mehrabi Soraya , Ababzadeh Shima , Sefat Farshid , Mozafari Masoud
Published: July 2018

Background:

Cell therapy is an important strategy for the treatment of incurable diseases
including those that occur in the Central Nervous System (CNS). Among different strategies, the
method of delivering or transplantation of cells into the brain has shown significant effects on regeneration.
In this study, a new protocol has been developed for the transplantation of adipose tissuederived
stem cells into the brain through Cerebrospinal Fluid (CSF) in rat models.

Methods:

For this purpose, a wide range of ages (7-30 days old) of male neonates of Wistar rats was
used. Moreover, human adipose tissue was obtained from a superficial layer of abdomen through liposuction
surgery. The size of the inserted part of needle to access middle cranial fossa and subarachnoid
space in animals with an average weight of 10-80 g was determined. In addition, to confirm the entrance
of needle into the subarachnoid space, CSF was aspirated slowly and then injection was done
within two minutes.

Results:

The findings showed the presence of transplanted human Adipose-Derived Stem Cells
(hADSC) in the cerebellum and basal ganglia following three days and also after two months that confirmed
the entrance of transplanted cells into the cerebrospinal fluid and migration of them into the
brain tissue. All the animals survived after the transplantation process, with the lowest side effects
compared to the available conventional methods.

Conclusion:

It can be concluded that the cells could be efficiently transplanted into CSF through subarachnoid
space by injection via superior orbital fissure with a minimally invasive technique.
Grasshopper Algorithm Optimized Fractional Order Fuzzy PID Frequency Controller for Hybrid Power Systems
Authors: Lal Deepak Kumar , Barisal Ajit Kumar
Published: July 2018

Background:

Due to the increasing demand for the electrical power and limitations of conventional energy to produce electricity.

Methods:

Now the Microgrid (MG) system based on alternative energy sources are used to provide electrical energy to fulfill the increasing demand. The power system frequency deviates from its nominal value when the generation differs the load demand. The paper presents, Load Frequency Control (LFC) of a hybrid power structure consisting of a reheat turbine thermal unit, hydropower generation unit and Distributed Generation (DG) resources.

Results:

The execution of the proposed fractional order Fuzzy proportional-integral-derivative (FO Fuzzy PID) controller is explored by comparing the results with different types of controllers such as PID, fractional order PID (FOPID) and Fuzzy PID controllers. The controller parameters are optimized with a novel application of Grasshopper Optimization Algorithm (GOA). The robustness of the proposed FO Fuzzy PID controller towards different loading, Step Load Perturbations (SLP) and random step change of wind power is tested. Further, the study is extended to an AC microgrid integrated three region thermal power systems.

Conclusion:

The performed time domain simulations results demonstrate the effectiveness of the proposed FO Fuzzy PID controller and show that it has better performance than that of PID, FOPID and Fuzzy PID controllers. The suggested approach is reached out to the more practical multi-region power system. Thus, the worthiness and adequacy of the proposed technique are verified effectively.
O state-building no contexto do Império em Negação: o caso da CPA no Iraque (2003-2004)
Authors: Hoff Natali Laise Zamboni , Blanco Ramon
Published: July 2018

Os processos de state-building vêm adquirindo cada vez mais relevância no cenário internacional, convertendose em importantes ferramentas para a estabilização de países pós-conflitos e promoção da paz. Apesar da centralidade que esses processos ocupam na política internacional, as compreensões sobre eles são majoritariamente compostas por análises técnicas e administrativas sobre a construção de instituições estatais por intermédio de atores externos. Esse tipo de abordagem permite que o caráter político do de state-building seja subtraído e o exercício do poder seja negado. Por isso, David Chandler diz que o Império está em negação e busca através das fórmulas burocráticas e terapêuticas do state-building evadir a sua responsabilidade, mas sem deixar de regular e controlar os Estados não-ocidentais. Tendo isso em conta, esse artigo busca compreender as dinâmicas e práticas envolvidas no processo de (re)construção do Estado no Iraque (2003-2004), liderado pela Coalitional Provisional Authority (CPA). A pesquisa busca observar se o caso iraquiano pode ser entendido a partir das contribuições de David Chandler sobre o Império em Negação. Para isso, o trabalho está divido em três seções, na primeira apresenta-se a definição de Chandler sobre o Império em negação e quais os principais mecanismos de regulação e controle contidos em seu contexto. A segunda seção concentra-se na atuação da CPA no Iraque, observando as medidas e estratégias utilizadas pela organização no país. A terceira seção trata da construção do Estado de Direito no Iraque e como ele foi utilizado pelas forças de ocupação para negar o poder exercido e evadir a responsabilidade frente às dificuldades do processo.
Диэлектрическая релаксация в тонких слоях стеклообразной системы Ge-=SUB=-28.5-=/SUB=-Рb-=SUB=-15-=/SUB=-S-=SUB=-56.5-=/SUB=-
Authors: Кастро Р.А. , Анисимова Н.И. , Кононов А.А.
Published: July 2018

AbstractThe results of studying dielectric relaxation processes in the Ge_28.5Pb_15S_56.5 glassy system are presented. The existence of the non-Debye relaxation process caused by the distribution of relaxors over the relaxation time according to the Cole–Cole model is revealed. The energy and structural parameters are calculated: the activation energy E _ p = 0.40 eV and the molecular dipole moment μ = 1.08 D. The detected features are explained within the model according to which the chalcogenide-glass structure is a set of dipoles formed by charged defects such as D ^+ and D ^–.
Home-Based Video Telemedicine for Dementia Management (Preprint)
Authors: Moo Lauren Rachel , Gately Megan , Jafri Zehra
Published: July 2018

BACKGROUND

Individuals with dementia exhibit high rates of behavioral problems and medical comorbidities which may challenge attending doctors’ visits. Video telemedicine may benefit people with dementia and their caregivers who often experience burden. However, data on video telemedicine into the homes of this cohort is lacking. The New England Geriatric Research Education and Clinical Center (GRECC) was the first facility in the United States to offer dementia management visits directly into patients’ homes using clinical video-conferencing telemedicine, known as Home Clinical Video Telehealth (Home-CVT). We analyzed reasons for enrolling in Home-CVT and visit satisfaction, comparing video telemedicine to in-person visits.

OBJECTIVE

To assess reasons for enrolling or not enrolling in Home-CVT and to compare acceptability of Home-CVT to in-person dementia management visits.

METHODS

Post-visit experience questionnaires were mailed to caregivers following in-person and Home-CVT dementia management visits. Additionally, we tracked reasons for declining or joining Home-CVT.

RESULTS

The primary reason for joining Home-CVT was convenience related to reduced travel and less disruption of daily routines. Lack of a home computer was the main reason for not enrolling. Families who chose Home-CVT reported equivalent visit satisfaction with in-person visits, with the added benefit of reduced need for transportation with Home-CVT.

CONCLUSIONS

Home-CVT is an acceptable alternative visit format. Given recent policy changes regarding reimbursement for home video telemedicine, Home-CVT offers a promising dementia service delivery model, especially for rural patients and others for whom travel to a specialty clinic is burdensome.
Drug Management Evaluation Focusing on Procurement at Muntilan District Hospital Magelang in Year 2015–2016
Authors: Mahdiyani Ulfah , Wiedyaningsih Chairun , Endarti Dwi
Published: July 2018

Planning and procurement which are parts of management drug supply give the biggest effect on drug inventory and hospital’s cost. This study aimed to describe planning and procurement systems in Pharmacy Department of Muntilan Regional Public Hospital in year 2015–2016. Study was conducted by comparing the real drug management supply indicators with standard indicators. This study was conducted on December 2016 untill February 2017. Data was collected using retrospective approach for secondary data including data of finance, drug procurement and use; as well as primary data collected by interview with hospital director, and heads of pharmacy and finance department. Data was analyzed using descriptive technique. The result showed that drug management had not been fully in accordance with the standards. It was indicated from 7 measured indicators, one of them had been in accordance with the standard which was percentage of available fund compared with cost planned. The other 6 indicators had not been in accordance with the standard: percentage of drug procurement with fund allocation, percentage of drug item planned compared with the using, percentage total quantities of a drug item with the using, the procurement frequency of each drug item, frequency uncompleted of orderlist/contract, frequency of delayed rate in payment by hospital, and indicators that can’t be measured are proportion of the quantities of products actually recieved out of total quantities planned, and percentage of quantities used out of total quantities available for consumption after deduction of buffer stock.
Evaluation of Pharmaceutical Service and Management of Drug, Disposable Medical Supply, and Medical Equipment for Poned of Brebes Regency
Authors: Hendri Doni , Satibi Satibi , Endarti Dwi
Published: July 2018

Government regulations number 51 of 2009 and regulation of health minister number 74 year 2016 are the reference in conducting pharmaceutical care in PHC (Primary Health Care). The objectives of this research are: 1) Evaluate service, management, 2) Identify supporting, inhibiting factor, 3) Formulate solution to improve services, management of drug, disposable medical supply, and disposable medical equipment PONED Brebes district. Descriptive research was obtained by observation of LPLPO 22 PHC PONED 2016, evaluation of conformity with DOEN, national formulary, checklists, availability, adequacy, percentage and value damaged, expiration, out-of-stock duration, in-depth interview with head of the pharmaceutical section, head of maternal and child health, head of Brebes health office to identify supporting factors, inhibiting and formulating remedial solution Basic Priority Rating Scale (BPRS). Results of research showed that 1) service, drug management, disposable medical supply, disposable medical equipment by pharmacist was 54,55-59,09%, pharmacist technician was 27,27-31,82%, non-pharmacist was 13,64%, and clinical pharmacy services had not been fully implemented. Conformity of drug, disposable medical supply, disposable medical equipment with DOEN, Fornas, checklists, drug availability and adequacy with pharmacist were higher than pharmacy technician and non-pharmacist, in which it is not sufficient. Percentage of medication time span with low pharmacist from pharmacist technician and non-pharmacist; 2) Permenkes number 74 year 2016 became the supporting factor,of service, management, lacking of pharmacist, communication within PONED internals became the obstacle factor; and 3) solution for improvement including fulfillment of pharmacist at PHC PONED, evaluation upon planning, procurement at BLUD, requests to provincial health administrative, coaching and regular training. In general, drug services and management of drug, disposable medical supply, disposable medical equipment at PHC PONED in Brebes regency have not meet the predetermined standard.
Improving the packaging performance of low-density polyethylene with PCL/nanocellulose/copper(II)oxide barrier layer
Authors: Djordjevic Nenad , Marinkovic Aleksandar , Zivkovic Predrag , Kovacevic Danijela , Dimitrijevic Suzana , Kokol Vanja , Uskokovic Petar
Published: July 2018

A novel double layered hybrid materials, consisting of low density
polyethylene (LDPE) base layer and polycaprolactone (PCL) top layer
containing surface modified nanocellulose (NC) based nanocomposites in 0.5
and 2 % loadings, were studied in order to design multipurpose packaging
material. NC was covalently modified with maleic anhydride (MA) to obtain
NCMA, and upon co-precipitation of copper (II) oxide (CuO) on NC and NCMA
surface, NC-CuO and NCMA-CuO nanocomposite materials were produced. Two
drying methods, conventional and lyophilization, were applied to investigate
process influences on the properties of obtained hybrid material. Oxygen
transmission rate and antimicrobial activity were determined for all
produced hybrid materials. PE-PCL-NCMA-CuO-L2 exhibited the highest
antifungal properties, indicating contribution of MA residual group and
drying conditions (liophylisation) to achievement of 97 % reduction in cell
viability of C. albicans. The sample with 2 % of NCMA-CuO, PE-PCL-NCMA-CuO2,
demonstrated to be the most promising material regarding improvement in
antibacterial and antifugal activity, as well as 16 % lower value of the
oxygen transmission rate in comparison to pure LDPE.
Inversion charge density of MOS transistor with generalized logistic functions
Authors: Kevkic Tijana , Stojanovic Vladica , Petrovic Vera , Randjelovic Dragan
Published: July 2018

In this paper, the expression for the charge density in inversion layer at
the surface of semiconductor has been improved. The improvement is related
to the replacement of an empirical smoothing factor by new one which has
generalized logistic (GL) functional form. The introduction of the GL
function of the second type in the original interpolating expression leads
to continual and smooth transition of the inversion charge density (ICD)
between different regions of metal-oxide-semiconductor (MOS) operation.
Moreover, in this way any empirical determinations are avoided. The
simulated values of the ICD match closely with the numerical results of
implicit charge sheet model for a wide range of dopant concentration and
oxide thickness. In addition, the proposed GL fitting procedure has been
also extended in the case where quantum mechanical effects play important
role in inversion mode of scaled MOS devices.
Social Media and Voluntary Nonfinancial Disclosure: Evidence from Twitter Presence and Corporate Political Disclosure
Authors: Lei Lijun (Gillian) , Li Yutao , Luo Yan
Published: July 2018

This study uses a sample of 1,316 firm-year observations of S&P 500 companies (2012–2016) to investigate whether and how social media (i.e., Twitter) affects firms' voluntary nonfinancial disclosure (i.e., corporate political disclosure). Our results show that Twitter-adopting firms are generally more transparent in their disclosure of corporate political contributions and of related policies and board oversight. Moreover, firms with more Twitter followers and firms whose corporate political activities are targeted in more Twitter messages are more transparent in such disclosures. Our cross-sectional analysis suggests that this effect is stronger for firms whose stakeholders are more active on Twitter and firms that are less visible or more reputable. Our results remain robust to different econometric model specifications and controlling for alternative social media platforms. Taken together, our findings suggest that social media (i.e., Twitter) presence exerts pressure on firms' voluntary nonfinancial disclosure practices (i.e., corporate political disclosure).

JEL Classifications: G38; M41; M48.

Data Availability: Data are available from the sources indicated in the text.
FENOMENA WARIA DAN DAMPAK JANGKA PANJANG GANGGUAN PSIKIS KORBAN KEKERASAN SEKSUAL ANAK
Authors: AR-RIDHO ALI , SANTOSO MEILANNY BUDIARTI , HUMAEDI SAHADI , KRISNANI HETTY
Published: July 2018

Fenomena waria masih merupakan masalah yang belum mendapatkan perhatian khusus dari masyarakat. Permasalahan mereka belum mendapatkan urgensi intervensi baik dari kalangan akademisi maupun profesional. Fenomena ini juga masih banyak meninggalkan tanya Tanya besar di dalam masyarakat, yaitu terkait sebab dari permasalahan yang mereka hadapi. Terdapat banyak dimensi yang dapat dikaji untuk menjelaskan fenomena ini salah satunya dengan menggunakan kajian konstruksi emosional dalam ilmu psikologi yang menjelaskan tentang terbentuknya proses mental seseorang berdasarkan memori masa lalu. Dalam tulisan ini penulis menggunakan pendekatan kajian konstruksi emosional tersebut untuk mengurai sebab dan akar permasalaha waria yang kemudian dari kajian tersebut dapat ditentukan metode untuk mencegah dan mengintervensi permasalahan waria.
PENDIDIKAN BAGI ANAK TUNA GRAHITA (STUDI KASUS TUNAGRAHITA SEDANG DI SLB N PURWAKARTA)
Authors: SARI SITI FATIMAH MUTIA , BINAHAYATI BINAHAYATI , TAFTAZANI BUDI MUHAMMAD
Published: July 2018

Anak berkebutuhan khusus merupakan anak yang dilahirkan dengan kebutuhan-kebutuhan khusus yang berbeda dari manusia pada umumnya sehingga membutuhkan pelayanan khusus. Seseorang dengan memiliki hambatan kecerdasan sudah dipastikan bahwa ia adalah penyandang tunagrahita. Anak dengan tunagrahita memiliki kecenderungan kurang peduli terhadap lingkungannya, baik dalam keluarga ataupun lingkungan sekitarnya. Masyarakat pada umumnya mengenal tunagrahita sebagai retardasi mental atau terbelakang mental atau idiot. Menurut Kustawan, D. (2016) merupakan anak yang memiliki inteligensi yang signifkan berada dibawah rata-rata dan disertai dengan ketidakmampuan dalam adaptasi perilaku yang muncul dalam masa perkembangan. Ia juga mengatakan bahwa anak dengan tunagrahita mempunyai hambatan akademik yang sedemikian rupa sehingga dalam layanan pembelajarannya memerlukan modifikasi kurikulum yang sesuai dengan kebutuhan khususnya. Selaras dengan pendapat Kustawan bahwa anak dengan tunagrahita mempunyai hambatan dalam memproses pembelajaran bagi anak pada umumnya. Meskipun anak tunagrahita memiliki hambatan tersebut, tidak menutup kesempatan untuk menerima pendidikan yang layak dan tepat baik di rumah dan khususnya di sekolah. Agar anak dengan tunagrahita memiliki masa depan yang cerah, sama seperti anak pada umumnya.
PERAN GANDA BURUH PEREMPUAN SEKTOR INDUSTRI DALAM KELUARGA
Authors: RAHMAHARYATI ARISTYA , WIBHAWA BUDHI , NURWATI NUNUNG
Published: July 2018

Keterlibatan buruh perempuan dalam sektor industri tidak sedikitnya karena diakibatkan masalah ekonomi. Dalam hal tersebut, buruh perempuan dihadapkan dengan dua tuntutan peran yaitu sebagai ibu rumah tangga dan pencari nafkah yang keduanya menuntut kewajiban dan tanggung jawab untuk dilakukan secara bersamaan. Seringkali buruh perempuan mengalami dilema atas dua peran tersebut, perasaan bersalah kerapkali muncul ketika dihadapkan dengan situasi yang mengharuskan keberadaannya dalam keluarga. Namun disisi lain terikat oleh jam kerja yang panjang dan tidak teratur membuat buruh perempuan sulit mengatur tugas dalam keluarga. Karna sebagian besar waktu buruh perempuan dihabiskan di tempat kerja untuk mengejar target produksi pabrik industri. Hal tersebut akan menimbulkan konfik-konflik dalam diri perempuan maupun keluarga. Tak jarang diantara buruh perempuan mengalami stres, emosi serta gangguan kesehatan. Selain itu tak jarang menimbulkannya konflik dalam keluarga, mengalami perselisihan dengan anggota keluarga serta komunikasi tidak berjalan dengan baik. Akibat dari buruh perempuan tidak dapat melaksanakan peran-perannya, maka tidak menutup kemungkinan akan menimbulkan permasalahan. Dalam kesempatan ini pekerja sosial berperan untuk membantu buruh perempuan dalam hal meningkatkan kemampuan menjalankan perannya, memperbaiki relasi buruh perempuan dengan anggota keluarganya, memperbaiki komunikasi antar anggota keluarga serta mampu mengatasi masalah yang timbul dalam keluarga. Selain itu pekerja sosial dapat mengkaji kebijakan dari pemerintah mengenai jam kerja khususnya untuk perempuan.