bluuebunny/crossref_metadata_2025 huggingface dataset:
Aerosol Biologics for the Treatment of Eosinophilic Asthma
Authors: Syabbalo Nightingale
Published: January 2022

Asthma is a heterogeneous chronic airway disease comprising of distinct phenotypes characterized by different immunopathophysiologic pathways, clinical features, disease severity, and response to treatment. The phenotypes of asthma include eosinophilic, neutrophilic, mixed cellularity, and paucigranulocytic asthma. Eosinophilic asthma is principally a T helper type 2 (Th2)-mediated airway disease. However, several other immune and structural cells secrete the cytokines implicated in the pathogenesis of eosinophilic asthma. Innate type 2 lymphoid cells, mast cells, basophils, and eosinophils secrete Th2 cytokines, such as interleukin-4 (IL-4), IL-13, and IL-5. Additionally, airway epithelial cells produce alarmin cytokines, including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP). Alarmins are the key initiators of allergic inflammation at the sentinel mucosal surfaces. Innovative biotherapeutic research has led to the discovery of monoclonal antibodies which target and inhibit the immunopathological effects of the cytokines involved in the pathogenesis of eosinophilic asthma. Parenteral biologics targeting the inciting interleukins, include mepolizumab and reslizumab (anti-IL-5), benralizumab (anti-IL-5Rα), dupilumab (anti-4Rα), and tezelizumab (anti-TSLP). They have been shown to significantly reduce annualized exacerbation rates, improve asthma control, lung function, and quality of life. Currently, there are no pulmonary delivered aerosol biologics for topical treatment of asthma. CSJ117 is a potent neutralizing antibody Fab fragment against TSLP, formulated as a PulmoSol TM engineered powder, and is delivered to the lungs by a dry powder inhaler. Phase 2 placebo-controlled clinical trial evaluated the efficacy and safety of CSJ117. CSJ117 delivered as an inhaler attenuated the late asthmatic response (LAR), and the early asthmatic response (EAR) after allergen inhalation challenge (AIC) at day 84 of treatment. The maximum decrease in FVE1 from pre-AIC were significantly lower in the CSJ117 group compared to placebo (P = 029), during LAR. CSJ117 also significantly reduced fractional exhaled nitric oxide before AIC at day 83; and significantly reduced the allergen-induced increase in % sputum eosinophil count. Pulmonary delivery of biologics directly to the airway mucosal surface has several advantages over parenteral routes, particularly in treating airway diseases such as asthma. Inhaler delivered biologics, such as CSJ117 are innovative and attractive methods of future precision treatment of asthma, and other respiratory diseases.
Pharma Giant Expects Vaccines Lineup to Be Its Top Seller This Year
Authors: Panhale Mangesh
Published: January 2022

Coronavirus (COVID-19) was first seen in late December in Hubei province of Wuhan city in China. The highly contagious disease, caused by a virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is transmitted from humans to humans. After the first case in Wuhan, the disease rapidly spread to other parts of the globe.
Epidemiology and Outcome of Candidemia in ICU, Mashhad, a 6-Year Multi-Center Study
Authors: Bojdy Amin , Ahrari Yeganeh , Najafi Mona , Arian Mahnaz , khosravi Zeenyani Nasrin
Published: January 2022

Background and aim: candidemia is a state that usually happens in immunocompromised patients. Thus it is more prevalent in ICU patients. This status brings mortality and morbidity; however, the outcome is various in different ICU care settings. The aim of this study is to assess epidemiology of outcome of candidemia in ICU in Mashhad during a 6-year period. Method: in a cross-sectional study between 2012 and 2018 in different ICU centers affiliating with Mashhad University of Medical Sciences, data of candidemia patients were extracted from hospital information system. These data were demographic, past medical history, result of the culture, and antifungal treatment. Result: totally, 55 patients (22 men and 33 women) were included in the study. The mean age of the patients was 45.9±1.9 years. Furthermore, the mean duration of hospitalization and the mean duration of ICU care were 43 and 37 days, respectively. Five patients had a history of immunosuppressive treatment and four patients were prescribed antifungal treatment in their past medical history (all with fluconazole and none with Itraconazole). Eighteen patients received caspofungin, eleven Amphotericin B treatment, and two fluconazole with no significant difference in outcome of the patients regarding antifungal type. In case of coincident antibiotic treatment, Carbapenems were prescribed in 43 patients, Glycopeptides in 48 patients, 25 patients had Cephalosporin treatment, and 13 patients had Fluoroquinolone treatment with no significant difference regarding the antibiotic type. Conclusion: The mortality percent of candidemia in ICU was 69.1 within mean time of 37 days. Furthermore, there was no significant difference in outcome of the patients regarding using Caspofungin or Amphotericin. Timely initiation of antifungal regarding to the culture result may bring better outcomes.
Coronavirus - Drug Discovery and Therapeutic Drug Monitoring Options
Authors: Aziz Ahmad Kashif , Akram Nizami Saleha , Haroon Ghous Muhammad
Published: January 2022

COVID-19 is basically a medium size RNA virus and the nucleic acid is about 30 kb long, positive in sense, single stranded and polyadenylated. The RNA which is found in this virus is the largest known RNA and codes for a large polyprotein. In addition, coronaviruses are capable of genetic recombination if 2 viruses infect the same cell at the same time. SARS-CoV emerged first in southern China and rapidly spread around the globe in 2002–2003. In November 2002, an unusual epidemic of atypical pneumonia with a high rate of nosocomial transmission to health-care workers occurred in Foshan, Guangdong, China. In March 2003, a novel CoV was confirmed to be the causative agent for SARS, and was thus named SARS-CoV. Despite the report of a large number of virus-based and host-based treatment options with potent in vitro activities for SARS and MERS, only a few are likely to fulfil their potential in the clinical setting in the foreseeable future. Most drugs have one or more major limitations that prevent them from proceeding beyond the in vitro stage. First, many drugs have high EC50/Cmax ratios at clinically relevant dosages
Nanofiltration-Concept and Prospects
Authors: khan Nida tabassum
Published: January 2022

Nanofiltration is a pressure-driven film measure for fluid stage detachments. It is employed in numerous applications due to lower energy utilization and higher motion rates. The properties of nanofiltration membranes lie between those of non-permeable reverse osmosis layers and permeable ultrafiltration layers where partition is typically thought to be because of size rejection and, sometimes, charge impacts. The improvement of nanofiltration development as a practical association over continuous years has provoked a pivotal extension in its application in different endeavours, for instance, treatment of blurring effluents from the material industries, division of medications from development stocks, demineralization in the dairy business, and metal recovery from wastewater and disease clearing
Synthesis and characterization of new biodegradable gels based on 2,2 '-(ethylenedioxy) diethanethiol and pentaerythritol triacrylate
Authors:   al-Farabi  Kazakh  National  University,  Almaty,Kazakhstan, Shulen R. , Kazybayeva D. ,   al-Farabi  Kazakh  National  University,  Almaty,Kazakhstan
Published: January 2022

The work is devoted to the synthesis and characterization of gels based on the monomers pentaerythritol triaacrylate (PETriA) and 2,2 '-(ethylenedioxy)diethanethiol (EDODET) by thiol-ene "click" polymerization. The properties of the obtained gels were investigated by IR, Raman spectroscopy, mechanical analysis. Sol-gel analysis of obtained networks was carried out and the degradability was investigated. The results of IR spectroscopy confirmed the presence of -C = O and -C-O-C- groups in the composition of the obtained gels. The presence of unreacted C = C bonds conjugated with C = O, as well as thiol groups, varies depending on the composition of the initial monomer mixture (IMM). Raman spectroscopy results correlate well with IR data. Raman spectra also show C-S, S-S and SH characteristic bands that are difficult to identify by IR spectroscopy. It was found that the composition of MM affects the physicochemical properties of the synthesized gels. The highest yield of the gel fraction of obtained polymers was found in samples with an equimolar composition of IMM. The analysis of mechanical properties showed that gels with an excess of PETriA exhibit more elastic properties, and an excess of EDODET leads to the formation of networks with a higher crosslinking density. The study of the ability of obtained PETria-EDODET gels to degrade in a 3% solution of hydrogen peroxide showed that the polymer network degrades by 12% within 60 days. This property of the obtained gels can find application in the creation of targeted drug delivery systems with their prolonged release.
Imunoenzimske metode u procjeni kvalitete meda i pčelinjih proizvoda
Authors: Rotim Karla , Marković Ksenija , Vahčić Nada
Published: January 2022

Imunoenzimska ELISA metoda (engl. Enzyme-Linked ImmunoSorbent Assay) se istražuje u posljednje vrijeme kao brza, jednostavna i visokospecifična analitička metoda za unaprjeđenje i standardizaciju kvalitete meda i pčelinjih proizvoda. Med i pčelinji proizvodi se osim zbog nutritivne vrijednosti učestalo koriste i zbog brojnih pozitivnih bioloških učinaka, a ELISA metoda svoju primjenu u standardizaciji njihove kvalitete može pronaći kod utvrđivanja autentičnosti, botaničkog podrijetla te razlikovanja uzoraka prirodnog meda. Metoda se razvija u svrhu određivanja pčelinjih proteina i peptida, kao što su apalbumin-1 i defensin-1, a koji mogu predstavljati biljege izvornosti. Imunoenzimska ELISA metoda primjenu pronalazi i u određivanju peludi određene biljne vrste u svrhu utvrđivanja botaničkog podrijetla, te pri procjeni kvalitete određivanjem enzima, kao i u svrhu razlikovanja uzoraka prirodnog meda određivanjem specifičnih proteina.
Caregivers’ Satisfaction toward Under-Five Health Care Services Provided at Primary Health Care Centers in Al Karkh, Baghdad, 2020
Authors: Bahaa Al Deen Lamia D. , Fadhel Abeer Abdulkareem
Published: January 2022

Background: Satisfied caregivers are more likely to return for further care and to recommend the primary health care center services to others. Satisfied caregivers usually are compliant with the medical provider advice and the recommended treatment plan. Compliance will eventually lead to better health outcomes.
Method: A cross-sectional study with an analytic element was conducted during the period from the beginning of July to the end of September 2020. A convenient sample was collected from six primary health care centers in Al-Karkh side of Baghdad city where caregivers who attend those centers with their children for under-five health care services were interviewed using a structured questionnaire.Objective: To measure the caregivers’ satisfaction toward under-five health care services at primary health care centers in Baghdad Al-Karkh and their association with certain socio-demographic characteristics.
Results: A total of 500 caregivers were interviewed during the study period, the overall satisfaction was (64%). Caregivers were satisfied with primary health care centers cleanliness (77.8%), while they were highly dissatisfied with the communication with the nurses (78.8%), with the waiting time for a routine visit (74.6%), with nurses’ antiseptic methods (59.2%), and with the availability and adequacy of their children’s vaccines (65.4%).
Conclusions: The level of satisfaction of caregivers with under-five health care services provided at primary health care centers was relatively low. The study revealed that the less educated and older caregivers showed a significant higher level of satisfaction.
Grounded Theory in Second/Foreign Language Education Research
Authors: Rasuki Muhlisin
Published: January 2022

Grounded theory constitutes research methodology commonly used in the field of social sciences to investigate social phenomena. This research methodology, however, has rarely been used in the field of second/foreign language education. Given that second/foreign language education may be viewed as a social activity and that certain issues in second/foreign language education may be studied from social science perspectives, the present article surveys key literature on grounded theory. The goal is to help second/foreign language researchers assess the potential of this research methodology for studying relevant issues in the field of second/foreign language education.
nxiolytic Effect of the Hydro-alcoholic Extract of Anethum Graveolens Seed in Adult Female Wistar Rats: Modulation of GABA Receptors
Authors:   Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Shahabi Rana , Rostampour Mohammad ,   Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Khakpour Behrooz ,   Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Soltani Bahram ,   Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Saadat Farshid ,   Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Published: January 2022

Background: Along with industrial development and the increasing social complexity of societies, anxiety is one of the most prevalent psychological disorders. Medicinal plants are considered as an enrichment source of ingredients with biological activity. Objectives: The aim of this study was to evaluate the anxiolytic effect of Anethum Graveolens seed (AGS) and the possible involvement of Gamma-Aminobutyric Acid (GABA)-ergic system in the AGS effect. Materials & Methods: In the present experimental study, 64 female Wistar rats were divided into eight groups and received various concentrations of hydroalcoholic extract of AGS. To measure the level of anxiety, an elevated plus maze was used in a way that the animal’s head turned to an open arm. Prior to the injections of AGS extract, the GABA receptor antagonist was used. The results were analyzed by one-way analysis of variance using IBM SPSS v. 16. Results: Dose-response experiments showed that the AGS extract significantly decreased the anxiety indices compared to the control group (P<0.05). To analyze locomotor activity, our data showed that AGS extract at 0.1, 1, and 10 mg/kg could significantly increase locomotor activity compared to the control group (P<0.001). Pentylenetetrazol (PTZ (+extract significantly decreased the anxiolytic effect of AGS extract (P<0.01). Conclusion: Considering the anti-anxiety effects of AGS extract and a reduction in this effect caused by PTZ, part of the anti-anxiety effect of extract might be assumed via its interaction with GABA-ergic receptors. Further experimental trials; however, are required for the establishment of the anti-anxiety impact of AGS.
Third Ventricle Anaplastic Oligodendroglioma: A Case Report
Authors:   Department of Neurosurgery, Armed Forces Medical College, Pune, India, Ghosh Tamajyoti , Dey Subir ,   Department of Neurosurgery, Armed Forces Medical College, Pune, India
Published: January 2022

Background and Importance: Anaplastic Oligodendroglioma (ODG) constitutes 24% of all pediatric ODG. The mean age of presentation of ODG is 12±6 years. They are most common in frontal and temporal lobes; however, rare cases of intraventricular ODGs are reported. Most commonly they arise from the anterior part of lateral ventricles. Third ventricle ODG is extremely rare and only a few cases of lateral and third ventricle anaplastic ODG are reported. ODGs infiltrate locally to meninges and rarely have leptomeningeal spread. Thus, ODG forms a differential diagnosis of pediatric intraventricular tumor. Case Presentation: Here we present a case of a 15-month-old male child with raised intracranial pressure due to obstructive hydrocephalus. The patient was detected to be COVID-19 RT–PCR (Reverse Transcriptase Polymerase Chain Reaction) positive in the preoperative period and underwent emergency Right-sided Ventriculo Peritoneal (VP) shunt. His contrast MRI (Magnetic Resonance Imaging) Brain showed a 50×24×39 mm heterogeneously enhancing mass epicenter at third ventricle and extending to lateral and fourth ventricle with spinal drop metastasis. Preoperative differential diagnosis of Ependymoma was made and definitive surgery was done once the child recovered from COVID-19. However, his biopsy specimen pathology and Immunohistochemistry (IHC) were suggestive of anaplastic oligodendrogliomas and the child responded well to chemotherapy. Conclusion: Intraventricular ODG is an extremely rare pediatric tumor. Patients usually present with obstructive hydrocephalus. Contrast MRI findings are nonspecific and help in detecting leptomeningeal spread to the spine. IHC and chromosomal analysis are important diagnostic and treatment prognostication tools. These tumors have a high recurrence and poor prognosis despite gross total resection.
Multifocal Intradural Extramedullary Anaplastic Ependymoma With Intracranial Involvement at Presentation: A Case Report
Authors:   Department of Neurological Surgery, George Washington University Hospital, Washington, DC, USA, Mozaffari Khashayar , Stellon Michael A ,   Department of Neurological Surgery, George Washington University Hospital, Washington, DC, USA, Chalif Eric J ,   Department of Neurological Surgery, George Washington University Hospital, Washington, DC, USA, Rosner Michael K ,   Department of Neurological Surgery, George Washington University Hospital, Washington, DC, USA
Published: January 2022

Background and Importance: Ependymomas are a rare malignant neoplasm. Multifocal intradural extramedullary anaplastic ependymomas are even more of a rare entity with much of the current knowledge derived from case reports. We presented a case of a multifocal intradural extramedullary anaplastic ependymoma with intracranial involvement at presentation. Case Presentation: A 53-year-old male presented with urinary symptoms. Magnetic resonance imaging revealed two lesions along the spinal cord and two lesions, intracranially. Histopathological examination was consistent with the World Health Organization grade III anaplastic ependymoma. The patient was treated with the gross total resections of spinal cord lesions, followed by radiation therapy to the resection cavities and intracranial lesions. At the 10-month follow-up visit, he reported almost complete resolution of symptoms, and magnetic resonance imaging revealed no recurrence. Conclusion: Despite their rarity, ependymomas should be considered as the differential diagnosis when evaluating spinal tumors. Gross total resection followed by targeted radiotherapy appears to be an effective treatment modality for high-grade lesions.
Post-traumatic Cervical Spondyloptosis Without Neurological Deficits: A Case Report
Authors:   Department of Neurosurgery, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Rezaee Hamid , Abouie-Mehriz Mohammad Ali ,   Department of Neurosurgery, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Mohazzab-Torabi Saman ,   Department of Neurosurgery, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Keykhosravi Ehsan ,   Department of Neurosurgery, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Published: January 2022

Background and Importance: Traumatic cervical spondyloptosis is a rare and severe situation, i.e., associated with disabling neurological deficits. Case Presentation: We described an unusual clinical presentation of cervical spondyloptosis in a 49-year-old man without neurological impairment and severe neck pain. Moreover, C6-C7 spondyloptosis was assessed two days after the trauma. X-rays, Computed Tomography (CT) scans and Magnetic Resonance Imaging (MRI) demonstrated a C6 bi-pedicular fracture, C6-C7 facet dislocation with complete ptosis of C6 vertebral body over C7 and without spinal cord injury. The patient was managed with an intra-operative 4 Kg traction and underwent a posterior decompression, with reduced fracture/dislocation by bilateral completed facetectomies at C6, and fusion from C4 to T3. Conclusion: This case report emphasized that sometimes cervical spondyloptosis may occur without neurological deficit symptoms. Prompt clinical recognition and surgical removal are essential to prevent serious complications in this respect.
Prototipe Pengendalian Kualitas Udara Indoor Menggunakan Mikrokontroler dengan Sensor MQ135, DHT-22 dan Filter HEPA
Authors: Humairoh Gita Pati , Putra Rama Dani Eka
Published: January 2022

Indoor air pollution is a very serious health issue in comparison with outdoor air conditions. The current pandemic of COVID-19 causes people to remain indoors at all times. It is unimaginable that during this pandemic a smog-related disaster could occurs that could aggravate human respiratory diseases, thus requires additional air quality monitoring which can filter clean air into the room. The purpose of this study is to produce a prototype of air quality control that can provide a good air circulation system and hold the temperature and humidity in the room. This research was conducted with an Arduino Uno microcontroller and an MQ-135 gas sensor to detect CO2 gas and a DHT-22 sensor for measuring room temperature and humidity by comparing the results of using a HEPA filter. The research results of the prototype make it possible to generate the room temperature using a HEPA filter and air humidifier whose average is 27.7°C. Another parameter that is performed is the CO2 measurement, it is found that the average CO2 in the test using a HEPA filter and an air humidifier is 496 PPM.
Issues of the Risk-Based Approach
Authors: Kolesnikov E. Yu. , Vasileios F.
Published: January 2022

The purpose of the article was to analyze the problems currently standing in the way of more effective application of the risk-based approach methodology in the field of technogenic safety management. Methods — theoretical, inductive method, analysis of own experience, adopted normative legal acts, other publications. The main results of the work include the following: • despite the broadest use of the concept of “risk” in the field of technogenic safety management, there is no generally accepted interpretation of it to date; • often the evaluative concept of “risk” is mistakenly used instead of objectively existing risk factors; • quantifiably technogenic risk should be characterized by indicators of numerical nature, having vector objects, since two components should be indicated for the complete assignment of the indicator: the probability and the amount of damage; • experience shows that the methods of assessing the probabilistic component of risk indicators recommended by regulatory documents on the analysis and quantification of technogenic risk are accompanied by a very large uncertainty, therefore, instead of the traditional point statement, a more adequate method of assessment is the use of an interval approach that takes into account and allows quantifying this uncertainty; • the analysis showed that the so-called frequency approach, which is most often used to assess the probabilistic component of technogenic risk indicators, is used improperly, has no basis, since, as a rule, the phenomenon of statistical stability is not observed in the object area of the technosphere, there are no general aggregates; • in society and even among specialists, by now there is no understanding of the need to express all three components of damage from an accident (explosion/fire) in monetary terms, without which it is impossible to estimate and express the amount of total damage: —  in conclusion, four key problems that hinder the more effective use of the risk-based approach methodology in the field of technogenic safety management are listed; —  imperfection of the existing methodological base for the analysis and quantitative assessment of technogenic risk; — the problem of staffing in the field of technogenic risk management; — lack of national criteria for acceptable risk; —  complete disregard of the problem of uncertainty of the results of the COR, the lack of methodological support for the procedure of analysis and quantification of this uncertainty. Conclusion — the efforts of the entire community of specialists-researchers, legislators, practitioners engaged in various aspects of the problem of technosphere safety management are necessary to solve the tasks specified in the article.
Los efectos del cambio climático: otra razón para repensar las políticas migratorias
Authors: Gutiérrez López Eduardo Elías , Regalado Jacobo Hugo José , Miranda Galindo María del Carmen Leticia
Published: January 2022

Son muchos los retos globales que se avecinan; sin embargo, dentro de las discusiones en materia de política pública y legislación, poco se abordan las movilidades humanas como producto de los impactos del cambio climático. Si bien es cierto que el estudio de la relación entre migración y cambio climático es intrincado en comparación con los análisis que enfatizan en otras causas de las movilidades humanas, el escenario mundial que se proyecta demanda poner más atención en este factor. Este panorama mundial exige acciones de los gobiernos nacionales, así como repensar la racionalidad política con que actualmente se regula y gestiona el fenómeno migratorio. Por consiguiente, este trabajo tiene como objetivo realizar un análisis teórico de las principales posturas políticas en torno al fenómeno migratorio que han asumido los países y discutir hasta qué punto son pertinentes con las exigencias futuras en materia de cambio climático. La metodología empleada es analítica y parte de la base de descomponer en todas sus partes y tipos las principales políticas migratorias y contrastarlas con las legislaciones y acciones ejecutadas por los países y comunidades internacionales. Todo ello para establecer que las principales racionalidades políticas con las que se regula y gestiona el tema migratorio son insuficientes para atender las consecuencias de un fenómeno global e inevitable como el cambio climático.
Mineral water mining: quality for human consumption and health promotion
Authors: Nunes Antônio José Ribeiro
Published: January 2022

This study demonstrates the aspects of research and mining in groundwater mining. It was intended to demonstrate the guidelines of the Mining Code and Water Code as legal beacons under the management of the National Mining Agency – ANM, federal regulator of mineral water exploration; to analyze the importance of water quality control for human consumption, from the compliance with Anvisa Resolutions – RDC-274/275/2005, which standardize the vase and microbiological characteristics. The process to make groundwater available as a mineral good to be industrialized, goes through research stages, till the final test with laboratory analyses for water classification. In this context, its main question is: what is the importance of mineral water quality for human consumption in health promotion? And it aims to analyze the quality control of mineral water, its importance for human consumption and health promotion, as well as the benefits of it. For this, a bibliographic research was carried out, consultation with the relevant legislations, books and websites of public agencies. The results showed that mineral water mining is an activity present in the daily life of society and its regular consumption contributes to the quality and promotion of healthy living, through control of the exploitation of mineral water mines, under the management of the National Mining Agency – ANM. It was evidenced that mineral water brings important health benefits: in body thermoregulation, heat absorption, nutrient transport, oxygen, hormones, composition of blood plasma, digestive juice, saliva formation, tears and urine. Being composed of different levels of micronutrients, which help alleviating health problems, such as: weakening of bones and muscles, reduction of collagen, dryness of the skin, low revitalization of cells and mucosa, aggravated by low consumption of water with drug properties and product of secular use that affect health. It was concluded that the prevalence of each type of mineral water and its composition, from ferruginous, sulfurous, radioactive, magnesian and iodized, can help in therapeutic treatments.
RANCANG BANGUN APLIKASI PESAMLINE (PEMESANAN AMBULANCE ONLINE) BERBASIS ANDROID
Authors: Saputra Dedi , Haryani Haryani , Martias Martias , Surniandari Artika , Widianto Kudiantoro
Published: January 2022

Android adalah sistem operasi yang berbasis Linux untuk telepon seluler seperti telepon pintar dan komputer tablet seperti smartphone yang banyak beredar di pasaran atau bahkan yang kita gunakan dalam kegiatan sehari-hari. Android menyediakan platform terbuka bagi para pengembang untuk menciptakan aplikasi mereka sendiri yang dapat digunakan oleh bermacam-macam peranti bergerak. Penelitian ini dibuat untuk membantu masyarakat yang membutuhkan pelayanan Ambulance secara Online dalam situasi darurat, seperti pertolongan untuk korban kecelakaan, ibu melahirkan, dan situasi darurat lainya. Aplikasi pemesanan ambulan berbasis android ini akan menampilkan layanan pemesanan ambulan dimana sebagai sampel penelitiannya layanan Ambulan yang berada di wilayah Kota pontianak, dapat mengirimkan pemesanan darurat ke Ambulance terdekat dari lokasi pemesan melalui aplikasi PESAMLINE yang terpasang di smartphone, sehingga mempermudah pengguna dalam mendapatkan pelayanan Ambulance. Penelitian ini menggunakan Android Studio dan menggunakan bahasa pemograman java dalam pembuatan Aplikasinya. Untuk pengembangan perangkat lunaknya menggunakan model waterfall. Hasil dari penelitian ini diharapkan pengguna dapat mengakses aplikasi untuk mengirim pesan darurat ke Ambulance terdekat yang sudah terdaftar di aplikasi.
EVALUASI KELAYAKAN INVESTASI PROYEK APLIKASI DASHBOARD HASIL ANALISA KEPUASAN PENGGUNA WEBSITE UNIVERSITAS XYZ
Authors: Alfiarini Alfiarini , Apriadi Deni
Published: January 2022

Investasi sistem informasi dan teknologi informasi  yang besar umumnya di sertai dengan potensi resiko yang  besar dan dapat menimbulkan kerugian yang cukup besar apabila keputusan yang di ambil tidak tepat. Agar biaya investasi dan biaya berjalan yang di keluarkan tidak sia-sia maka manajemen perlu melakukan evaluasi dengan mengukur manfaat ekonomis dari proyek sistem informasi dan teknologi informasi  sebelum investasi dilaksanakan. Pengukuran manfaat  ekonomis suatu sistem informasi dan teknologi informasi  memerlukan metode yang dapat dirangkum secara menyeluruh dari manfaat ekonomis yang ditimbulkan bagi perusahaan atau organisasi. Hasil Investasi aplikasi dashboard hasil analisa kepuasan pengguna website Universitas XYZ dapat memberikan manfaat yang secara ekonomis memiliki kecenderungan nilai terus meningkat tiap tahunnya setelah pengembangan, dengan ROI=2148% di akhir tahun ke-tiga walapun berdasarkan hasil evaluasi proyek ini pada tahun pertama telah memberikan manfaat lebih besar dibanding nilai invetsasi ditambah dengan nilai operasional. Nilai manfaat yang di dapat lebih besar dari biaya investasi penggunaan dashboard  pada perguruan tinggi XYZ yang diukur dengan BCR, dimana pada penelitian ini terbukti bahwa   BCR >1, yang berarti bahwa investasi untuk dashboard hasil analisa kepuasan pengguna website Universitas XYZ layak.
ВІКОВІ ПАРАМЕТРИ ЛІНІЙНОГО РОСТУ ТЕЛИЦЬ СУМСЬКОГО ВНУТРІШНЬОПОРОДНОГО ТИПУ УКРАЇНСЬКОЇ ЧОРНО-РЯБОЇ МОЛОЧНОЇ ПОРОДИ
Authors: Ладика Володимир Іванович , Хмельничий Сергій Леонтійович
Published: January 2022

Наведені результати досліджень з оцінки ремонтних телиць сумського внутрішньопородного типу української чорно-рябої молочної породи за показниками росту і розвитку за використання лінійних промірів статей екстер’єру та приростів живої маси. Оцінку ремонтних телиць за основними екстер’єрними промірами та живою масою у межах сформованих вікових груп від народження до 18-місячного віку проводили в стаді приватного підприємства “Буринське” Підліснівської філії Сумського району. Визначали 11 основних промірів статей: висоту в холці та крижах, глибину та ширину грудей (мірною палицею); ширину в клубах, у кульшових зчленуваннях та сідничних горбах, бічну довжину заду (мірним циркулем); навкісну довжину тулуба, обхват грудей та п’ясті (мірною стрічкою). Зважувались тварини у день взяття промірів. Найбільш інтенсивним ростом характеризувалися телиці у молочний період свого розвитку, надалі цей процес сповільнювався. Реалізація цієї особливості забезпечила відносний приріст живої маси від народження до 3-х місячного віку на рівні 97,0%, у наступні періоди – від 3 до 6 міс. відповідно – 50,8%, від 6 до 9 міс. – 29,9%, від 9 до 12 міс. – 20,9%, від 12 до 15 міс. – 13,7% та від 15 до 18 міс. – 11,9%. Розвиток живої маси ремонтних телиць сумського внутрішньопородного типу забезпечив її приріст на час парувального віку на рівні 425 кг, забезпечивши вимоги бажаного типу. На основі вікової динаміки росту розроблені параметри лінійних ростових стандартів від народження до 18-ти місячного віку, використання яких дозволяє контролювати процес інтенсивності вирощування ремонтних телиць.
ВПЛИВ РІЗНИХ СПОЛУК МІКРОЕЛЕМЕНТІВ НА ВРОЖАЙ, ПОЖИВНУ ЦІННІСТЬ ТА НАКОПИЧЕННЯ 137CS У ЗЕЛЕНІЙ МАСІ ВІВСА
Authors: Біденко Володимир Миколайович , Мамченко Віталій Юрійович , Ковальчук Тетяна Іванівна
Published: January 2022

Про дефіцит мікроелементів у ґрунтах, рослинах, організмі тварин у своїх працях ще у 1971, 1972 роках вказував М. О. Судаков [1], що на Поліссі Житомирщини відмічається низький вміст Мангану, Цинку, Кобальту, місцями Купруму, а особливо Йоду. Це є однією із причин поширення у цій зоні специфічних захворювань рослин, тварин та людей. У рослин при прояві цих захворювань спостерігається хлороз, розетковість, дрібнолистість, у тварин та людей відмічається гіпокобальтоз, аліментарна анемія, переродження щитовидки, випадання волосся тощо. Відповідно до вищевикладеного, завданням наших досліджень було, вивчити вплив різних сполук мікроелементів Мангану, Кобальту, Купруму, Цинку на врожай зеленої маси вівса, його поживну цінність та перехід Цезію-137 із ґрунту у рослину. Порівняти ефективність застосування комплесонатів вищевказаних мікроелементів із солями. У результаті досліджень було встановлено, що поверхневе підживлення вівса солями і комплексонатми мікроелементів сприяло підвищенню врожаю зеленої маси на 22,8 і 18,8%, відповідно, нагромадженню у вегетативній масі сирого та перетравного протеїну, клітковини, мікроелементів та зниження переходу Цезію-137 із ґрунту у зелену масу рослини в 1,7 і 1,8 рази.
ЗАБІЙНІ ЯКОСТІ СВИНЕЙ РІЗНИХ ГЕНОТИПІВ
Authors: Бірта Габріелла Олександрівна , Бургу Юрій Георгійович , Флока Людмила Валеріївна , Горячова Олена Олександрівна , Хмельницька Євгенія Вікторівна
Published: January 2022

В статті досліджено забійні та м’ясо-сальні якості тварин різних генотипів. Було визначено наступні показники: передзабійна маса; забійна маса; забійний вихід; довжина напівтуші; товщина шпику; площа «м’язового вічка»; вихід м’яса і сала в туші, морфологічний склад туш, масу м’язової тканини. На основі одержаних експериментальних даних проведено дисперсійний аналіз впливу форм годівлі на забійні якості свиней. В середньому по досліду загальна дисперсія, що показує загальну мінливість ознаки при забої свиней живою масою 100 кг, коливалась від 0,93 у свиней миргородської породи до 1,01 у полтавської м’ясної породи. Найбільшою частка впливу форми годівлі на забійний вихід спостерігалась у свиней м’ясних генотипів, зокрема у полтавської м’ясної 84,9-88,8% та червоної білопоясої породи свиней 86,4-83,6%. Результати забою засвідчили перевагу м'ясних генотипів над представниками сальних і м'ясо-сальних порід за показниками забійного виходу, довжини напівтуші, товщини шпику та маси окосту. В сучасних умовах виробництва свинини відгодівля тварин потребує врахування певних проблем, пов’язаних із впливом умов утримання, повноцінної годівлі, статі та результативності виробництва – середньодобові прирости, товщину шпику, витрати корму на одиницю продукції. Відгодівлю свиней різної статі необхідно організовувати відповідно до їх потреби у поживних речовинах.
АДАПТАЦІЙНІ ОЗНАКИ КОРІВ ЗА ЗМІНИ УМОВ УТРИМАННЯ УПРОДОВЖ ЗИМОВОГО ТА ЛІТНЬОГО ПЕРІОДІВ РОКУ
Authors: Борщ Олександр Олександрович , Борщ Олександр Васильович , Бабенко Олена Іванівна
Published: January 2022

Метою цієї роботи було вивчити вплив сезону року на продуктивні і етологічні показники та комфорт корів (ІІ і ІІІ лактацій) української чорно-рябої молочної породи при зміні умов утримання і доїння упродовж адаптаційного періоду. Дослідження проводили у СВК «Острійківське» (Білоцерківський район, Київська область) на коровах ІІ і ІІІ лактацій, котрих переводили із капітального приміщення у легкозбірне упродовж літнього (n=34) та зимового (n=58) періодів. Поголів’я корів утримувалось упродовж листопада-березня прив’язно у приміщенні капітального типу (ДхШхВ 76х12х6 м) на 100 голів, а упродовж квітня-жовтня – безприв’язно на вигульних майданчиках. Доїння відбувалось у приміщенні на установці УДМ-200. Тварин було переведено до легкозбірного приміщення з безприв’язно-боксовим утриманням на 400 голів (100х36х10,5 м) з доїнням у доїльному залі на установці «Карусель». Дослідження проводили упродовж адаптаційного періоду (30 діб після зміни умов утримання). Адаптаційний період було розділено на VI періодів тривалістю у 5 діб кожен. Доведено вплив сезону року на адаптаційні ознаки корів ІІ і ІІІ лактацій до зміни умов утримання та доїння. Поведінкові реакції у групі тварин, котрих переводили у нові умови утримання і доїння упродовж 30-денного адаптаційного періоду у теплі місяці року (квітень-жовтень) відповідали рекомендованим показникам відповідно до графіку «ідеального дня» для молочних корів починаючи з IV періоду (16 доба), а у групі корів котрі змінювали умови утримання в холодний період (листопад-березень) – починаючи з VI періоду (26 доба). До того ж у групі тварин, котрі змінили умови утримання в теплий період року, спостерігали вищі значення чотирьох індексів комфорту для боксового утримання корів та продуктивності (на 2,04-2,60 кг >; Р<0,95), порівняно з групою корів, котрих переводили у нові умови утримання і доїння упродовж холодного періоду.
The Productivity of Wineries – An Empirical in Moldova
Authors: Darma Surya , Lestari Dirga , Darma Dio Caisar
Published: January 2022

Wine has historical importance to the Moldovan economy. Since the 18th century, it is noted, this commodity has contributed to revitalizing the export market and has prospered many workers. It’s not enough to stop there. Wine also plays a role in lifting Moldova’s status because it is an inspiration for other countries that have similar potential in rural areas. The goal of this research was to identify how large the land size, seed, and labor are for the productivity of wineries in Moldova with 2 models. We intend to examine and explain the relationship between independent and dependent variables using panel data in 5 regional units (Bălţi, Chisinau, Bender, Gagauzia, and Transnistria). The analytical tool used is a multiple regression through SPSS software. Empirical findings produced are that there is a positive significant influence on land size and labor on productivity, while the seed has a negative-significant effect.. This discovery also resulted in an important experience, which is regulated to stimulate the productivity and potency of wine through the relaxation of the agrarian sector.
Evaluation of E-Scooter Media Coverage
Authors: Caspi Or , Smart Michael J
Published: January 2022

This study examines the attitudes and common themes of 840 e-scooter news articles from across the US, published between 2017 to 2020. Sentiment analysis suggests that media coverage does not appear to be predominantly in favor or against shared e-scooters. A word count analysis shows that the most discussed themes were conflicts with other road users, safety concerns, and regulation efforts. The findings reveal differences between regions but also common patterns, such as the decline in negative coverage with time.
Bajareque tecnificado. Evaluación de energía incorporada y emisiones de CO2 en comparación con la edificación convencional Sistema constructivo alternativo para la vivienda rural de Torreón, México
Authors:   Universidad Autónoma de Coahuila, González Alleck , Guerrero Luis
Published: January 2022

La edificación de estructuras de bajareque ha demostrado ser altamente sostenible desde el punto de vista ecológico, económico y sociocultural por lo que sirvió como referente para la realización de un prototipo tecnificado en la Universidad Autónoma de Coahuila en Torreón.A partir de la cuantificación de materiales se ha analizado comparativamente el peso volumétrico, la energía incorporada y las emisiones de CO2 con relación a un modelo realizado con sistemas constructivos convencionales, demostrándose de manera cuantitativa las destacables cualidades ecológicas del sistema alternativo construido con bajareque tecnificado.
Mitigación y adaptación al efecto de isla de calor urbana de clima cálido seco El caso de Hermosillo, Sonora
Authors:   Universidad de Sonora, Mercado Laura
Published: January 2022

En la ciudad de Hermosillo, Sonora en las últimas décadas, se ha transformado el uso de suelo, superficie urbana, densidad poblacional, tránsito vehicular y las actividades de la población, generado cambios en la climatología urbana, haciéndose presente el fenómeno llamado Isla de Calor Urbana (ICU) que deteriora las condiciones ambientales y de habitabilidad urbana principalmente en comunidades vulnerables de clima cálido seco (Ruiz, Correa, & Cantón, 2012). Es así que conocer la ubicación y morfología de la ICU se hace relevante en cuanto a planeación urbana, a manera de herramienta de diseño para el análisis y mitigación de la misma y aumentar la resiliencia de la ciudad frente a estos efectos del Cambio Climático. El objetivo del presente trabajo es identificar las causas que provocan la formación del fenómeno como el remplazo de superficies naturales por artificiales, selección de materiales del entorno urbano y su geometría y aumento en el calor antropogénico.
Análisis estadístico de características geométricas y mecánicas del bloque hueco de concreto de Tuxtla Gutiérrez
Authors:   Universidad Autónoma de Chiapas, Ruiz Janio , Godínez Eber ,   Universidad Autónoma de Chiapas
Published: January 2022

Se presentan los resultados de un análisis estadístico para la caracterización geométrica y mecánica de bloques huecos de concreto, utilizados en construcciones de estructuras de mampostería en Tuxtla Gutiérrez, principalmente destinadas a vivienda. Se consideró una base de datos de ensayos realizados a 130 piezas, de 13 proveedores diferentes de la región. El análisis incluye las medidas de tendencia central de la geometría, la absorción de agua, la resistencia a cortante y la correlación entre el esfuerzo cortante resistente y las características físicas y geométricas de las piezas. Se registraron variaciones relevantes de la altura y longitud de los bloques respecto de lo establecido en las normas de construcción usualmente empleadas como referencia, aunque el espesor de estos cumple con los requisitos mínimos. Se proponen valores mínimos de la resistencia a cortante de las unidades ensayadas. El estudio de correlación entre el esfuerzo cortante máximo y el porcentaje de absorción indica que, a mayor porosidad de los bloques, disminuye su resistencia a cortante. La correlación entre el esfuerzo cortante máximo y el área neta muestra que la resistencia al esfuerzo cortante depende en menor medida de esta área que de la porosidad de la pieza. Finalmente, el análisis de correlación contra los espesores de las piezas señala que estos influyen menos en la resistencia de las piezas que el área neta y la porosidad.
Anton Korošec in štajerski liberalci
Authors: Perovšek Jurij
Published: January 2022

One of the most important Slovenian politicians of the 20th century, Dr. Anton Korošec (1872–1940), started his political career in Styria, which was the foundation for his later ascend in the Austrian, Slovenian and Yugoslav territory. During the Austrian era, as he was a Catholic politician, his main adversaries in his local Lower Styrian surroundings were liberals, which coincided well with the then prevailing political division. They named him as the "general" of the Catholic political party, the Slovenian Peasant Union in Styria, which won the state (1907, 1911) and parliamentary (1909) elections and had absolute dominance in Styria.
Brejčev drugi mandat: politični izzivi Deželne vlade za Slovenijo v letu 1920
Authors: Rahten Andrej
Published: January 2022

The article deals with the main political challenges of the Provincial Government for Slovenia led by Janko Brejc, one of the most prominent Slovene political leaders in the post-imperial transition era. Based on the archival sources and different press reports, the article presents the crucial political developments in Slovenia in 1920, during Brejc's second term as the provincial prime minister, especially the April strike and the Carinthian Plebiscite.
Maribor med obema vojnama in vprašanje vojaške infrastrukture
Authors: Kladnik Tomaž , Matjašič Friš Mateja
Published: January 2022

Basing on the research of archival sources and newspapers, the article discusses the urban development of the city of Maribor from the perspective of construction and change of use of the existing military infrastructure, its influence on the city's development and its economic and everyday life in the period between the both world wars. For seventy years after the construction of the Southern Railway (1846), Maribor had been in the centre of traffic routes in the empire. Since one of the biggest military infrastructures in this part of Austria-Hungary was situated in Maribor, the city also had an important military-strategic position. With the downfall of Austria-Hungary and the creation of a new State of Slovenes, Croats and Serbs, the geostrategic position of Maribor changed considerably. Nevertheless, with its position and military infrastructure density, it preserved its important military role even in the new state. The discussed period in the city was thus marked by negotiations between the civil and military administration considering the ownership of the military infrastructure and the paying of its rent.