bluuebunny/crossref_metadata_2025 huggingface dataset:
Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis
Authors: Sakakibara Yasufumi , Hirota Yu , Ibaraki Kyoko , Takei Kimi , Chikamatsu Sachie , Tsubokawa Yoko , Saito Takashi , Saido Takaomi C. , Sekiya Michiko , Iijima Koichi M.
Published: June 2021

Background: The locus coeruleus (LC), a brainstem nucleus comprising noradrenergic neurons, is one of the earliest regions affected by Alzheimer’s disease (AD). Amyloid-β (Aβ) pathology in the cortex in AD is thought to exacerbate the age-related loss of LC neurons, which may lead to cortical tau pathology. However, mechanisms underlying LC neurodegeneration remain elusive. Objective: Here, we aimed to examine how noradrenergic neurons are affected by cortical Aβ pathology in AppNL-G-F/NL-G-F knock-in mice. Methods: The density of noradrenergic axons in LC-innervated regions and the LC neuron number were analyzed by an immunohistochemical method. To explore the potential mechanisms for LC degeneration, we also examined the occurrence of tau pathology in LC neurons, the association of reactive gliosis with LC neurons, and impaired trophic support in the brains of AppNL-G-F/NL-G-F mice. Results: We observed a significant reduction in the density of noradrenergic axons from the LC in aged AppNL-G-F/NL-G-F mice without neuron loss or tau pathology, which was not limited to areas near Aβ plaques. However, none of the factors known to be related to the maintenance of LC neurons (i.e., somatostatin/somatostatin receptor 2, brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3) were significantly reduced in AppNL-G-F/NL-G-F mice. Conclusion: This study demonstrates that cortical Aβ pathology induces noradrenergic neurodegeneration, and further elucidation of the underlying mechanisms will reveal effective therapeutics to halt AD progression.
Core-Centered Connection Abnormalities Associated with Pathological Features Mediate the Progress of Cognitive Impairments in Alzheimer’s Disease Spectrum Patients
Authors: Yao Weina ,   Alzheimer’s Disease Neuroimaging Initiative, Chen Haifeng , Sheng Xiaoning , Zhao Hui , Xu Yun , Bai Feng
Published: June 2021

Background: Abnormal default mode network (DMN) was associated with the progress of Alzheimer’s disease (AD). Rather than treat the DMN as a unitary network, it can be further divided into three subsystems with different functions. Objective: It remains unclear the interactions of DMN subsystems associated with the progress of cognitive impairments and AD pathological features. Methods: This study has recruited 187 participants, including test data and verification data. Firstly, an imaging analysis approach was utilized to investigate disease-related differences in the interactions of DMN subsystems in test data (n = 149), including 42 cognitively normal subjects, 43 early mild cognitive impairment (EMCI), 32 late mild cognitive impairment (LMCI), and 32 AD patients. Brain-behavior-pathological relationships regarding to the interactions among DMN subsystems were then further examined. Secondly, DMN subsystems abnormalities for classifying AD spectrum population in the independent verification data (n = 38). Results: This study found that the impaired cognition relates to disturbances in the interactions between DMN subsystems but preferentially in core subsystem, and the abnormal regulatory processes of core subsystem were significantly associated with the levels of cerebrospinal fluid Aβ and tau in AD-spectrum patients. Meantime, the nonlinear relationship between dysfunctional core subsystem and impaired cognition was observed as one progresses through the stages of MCI to AD. Importantly, this classification presented a higher sensitivity and specificity dependent on the core-centered connection abnormalities. Conclusion: The abnormal interaction patterns of DMN subsystems at an early stage of AD appeared and presented as core-centered connection abnormalities, which were the potential neuroimaging features for monitoring the development of AD.
LR-type fully Pythagorean fuzzy linear programming problems with equality constraints
Authors: Akram Muhammad , Ullah Inayat , Allahviranloo Tofigh , Edalatpanah S.A.
Published: June 2021

A Pythagorean fuzzy set is a powerful model for depicting fuzziness and uncertainty. This model is more flexible and practical as compared to an intuitionistic fuzzy model. This research article presents a new model called LR-type fully Pythagorean fuzzy linear programming problem. We consider the notions of LR-type Pythagorean fuzzy number, ranking for LR-type Pythagorean fuzzy numbers and arithmetic operations for unrestricted LR-type Pythagorean fuzzy numbers. We propose a method to solve LR-type fully Pythagorean fuzzy linear programming problems with equality constraints. We describe our proposed method with numerical examples including diet problem.
Slow Motion Analysis of Repetitive Tapping (SMART) Test: Measuring Bradykinesia in Recently Diagnosed Parkinson’s Disease and Idiopathic Anosmia
Authors: Simonet Cristina , Galmes Miquel A. , Lambert Christian , Rees Richard N. , Haque Tahrina , Bestwick Jonathan P. , Lees Andrew J. , Schrag Anette , Noyce Alastair J.
Published: June 2021

Background: Bradykinesia is the defining motor feature of Parkinson’s disease (PD). There are limitations to its assessment using standard clinical rating scales, especially in the early stages of PD when a floor effect may be observed. Objective: To develop a quantitative method to track repetitive tapping movements and to compare people in the early stages of PD, healthy controls, and individuals with idiopathic anosmia. Methods: This was a cross-sectional study of 99 participants (early-stage PD = 26, controls = 64, idiopathic anosmia = 9). For each participant, repetitive finger tapping was recorded over 20 seconds using a smartphone at 240 frames per second. From each video, amplitude between fingers, frequency (number of taps per second), and velocity (distance travelled per second) was extracted. Clinical assessment was based on the motor section of the MDS-UPDRS. Results: People in the early stage of PD performed the task with slower velocity (p < 0.001) and with greater frequency slope than controls (p = 0.003). The combination of reduced velocity and greater frequency slope obtained the best accuracy to separate early-stage PD from controls based on metric thresholds alone (AUC = 0.88). Individuals with anosmia exhibited slower velocity (p = 0.001) and smaller amplitude (p < 0.001) compared with controls. Conclusion: We present a simple, proof-of-concept method to detect early motor dysfunction in PD. Mean tap velocity appeared to be the best parameter to differentiate patients with PD from controls. Patients with anosmia also showed detectable differences in motor performance compared with controls which may suggest that some were in the prodromal phase of PD.
Pemberdayaan Masyarakat Kota di Wilayah RW VI Kelurahan Jatimulyo Malang Melalui Model Budidaya Sayur Organik
Authors: Murwani Indiyah , Muslikah Siti , Mardiyani Siti Asmaniyah
Published: June 2021

Ibu-ibu yang tinggal di wilayah RW VI sebagian tidak bekerja sehingga masih memiliki waktu untuk melakukan  kegiatan produktif,  dengan cara melakukan budidaya sayur organik. Metode yang dilakukan dengan  melatih dan praktek cara mengelola sampah organik menjadi kompos yang dapat dimanfaatkan sebagai media tanam sayuran. Sempitnya lahan bertanam diatasi dengan  sistem tanam vertikultur. Data yang diperoleh bahwa kesadaran masyarakat untuk tidak membuang sampah di sungai cukup tinggi yaitu sebesar 100 %, warga yang membuang sampah di pekarangan sendiri hanya 10%, karena ada petugas sampah yang selalu mengambil sampah. Dari hasil pengamatan di lapang bahwa ibu-ibu sudah melakukan pemilahan sampah mulai dari dapur, dengan memilih sampah anorganik yang dijual ke tukang rombeng, sebesar 75 %. Ibu-ibu yang melakukan pemilahan sampah organik dan  memanfaatkan sebagai bahan kompos masih cukup rendah, yaitu  sebesar 35 %. Oleh karena itu tim terfokus melakukan penyuluhan terkait pemanfaatan sampah organik rumah tangga sebagai bahan baku kompos yang dapat dipergunakan sebagai media tumbuh bagi kebun sayur vertikultur. Kegiatan penyuluhan dilakukan 2 kali yakni pemberian materi dan praktek.  Materi utama yang diberikan adalah pemanfataan sampah organik sebagai kompos dan praktek budidaya sayuran secara vertikultur.
Pemberdayaan Peserta Didik Melalui Program Kewirausahaan, Pendidikan Lingkungan, dan Budaya Literasi
Authors: Mabaroh Barotun , Sugianti Sugianti , Nadif Achmad , Khoiri Miftahul , Sulistyowati Evi
Published: June 2021

Program pengabdian kepada masyarakat melalui Kuliah Kerja Nyata Tematik (KKNT) bertujuan membangun jiwa kewirausahaan, mengolah sampah menjadi barang berguna, dan menciptakan budaya literasi bagi siswa-siswi di lingkungan sekolah MA Al Furqon Bugul Lor Kota Pasuruan. Kegiatan berupa penyampaian sosialisasi dan pelatihan pembuatan coklat praline. Selain itu, tim pengabdian KKNT juga memberikan pelatihan pembuatan kerajinan tangan dari kain perca menjadi gantungan kunci, bross, dan kotak pensil. Kegiatan pendidikan lingkungan berupa sosialisasi kepada siswa-siswi mengenai pembuatan tempat sampah organik dan nonorganik serta penanaman tanaman hias pada botol bekas. Dengan kegiatan ini diharapkan siswa-siswi menyadari betapa pentingnya kepedulian terhadap lingkungan. Kegiatan terakhir adalah meningkatkan budaya literasi bagi siswa-siswi melalui pembuatan papan motivasi, labelling, dan penataan ulang perpustakaan sekolah menjadi ruang baca yang lebih representatif. Hasil dari kegiatan KKNT mendapatkan respon dan apresiasi yang memuaskan dari pihak sekolah. Tim pengabdian KKNT berharap kegiatan ini dapat dilaksanakan secara berkesinambungan untuk mendorong kreatifitas siswa-siswi.
Analysis of Public Opinion Sentiment on Instagram regarding Covid-19 with SVM
Authors: Kurniasari Iin , Kusrini Kusrini , Fatta Hanif Al
Published: June 2021

Perkembangan teknologi dewasa ini mendorong masyarakat untuk selalu tanggap teknologi, terlebih di era pandemi covid-19 yang selalu mengedepankan social distancing. Media sosial digunakan sebagai suatu alat untuk menyampaikan opini masyarakat kepada khalayak. Dalam penelitian ini, penulis melakukan penelitian tentang opini masyaraat pada media sosial instagram dengan mengguakan Support Vector Machine. Setelah dilakukan uji akurasi dan presisi ternyata SVM belum sesuai digunakan sebagai algoritma yang dapat menangkap urutan karena susunan kata yang dibolak-balik meskipun maknanya berbeda tetap bermakna sama oleh mesin SVM, hal ini dibuktikan juga dengan jumlah akurasi yang kecil.yaitu 59%. Sehingga diperlukan langkah untuk bisa diteliti dengan algoritma lain misalnya algoritma HRRN (Highest Response Ratio Next) atau LSTM (Long Short-Term Memory) yang memperhatikan urutan dan proses dengan rasio respon paling tinggi. Jika berdasarkan pendekatan ekstraksi fitur SVM dengan pendekatan count vector, tf-idf word level, tf-idf ngram level dan tf-idf char level. Dalam skenario ini nilai akurasi tertinggi terdapat pada perhitungan dengan menggunakan ekstraksi fitur count vector dan tf-idf ngram level.
Implementation of Steganalysis Technique Using Chi Square Attack Method on Android-Based JPEG Stego Image Format
Authors: Yanti Dama , Utomo Yudo Bismo , Mukminna Halimahtus
Published: June 2021

Steganografi merupakan seni dalam menulis pesan rahasia untuk menyembunyikan informasi dengan cara meniyisipkan pesan pada suatu citra, sehingga tidak menutup kemungkinan steganografi dimanfaatkan untuk tujuan kriminal atau penyisipan file berbau pornografi.  Sedangkan steganalysis merupakan teknik untuk mendeteksi keberadaan pesan yang tersembunyi pada cover image.  Pada penelitian ini menggunakan teknik steganalysis dengan metode chi-square attack untuk mendeteksi keberadaan pesan secara statistik.  Tujuan dari penelitian ini adalah mengembangkan teknik steganalysis dengan menggunakan metode chi-square attack untuk mendeteksi stego-image berformat JPEG dan mengetahui hasil analisa dari metode chi-square attack yang diterapkan pada aplikasi Android Studio. Metode yang digunakan pada penelitian ini adalah metode waterfall, yang terdiri dari tahap analisis kebutuhan, tahap desain, tahap implementasi, tahap verifikasi dan tahap pemeliharaan. Hasil teknik steganalysis dengan metode chi square attack, yaitu uji coba pertama menghasilkan nilai selisih pada ukuran kapasitas file sebesar 1 hingga 12 persen, yang membuktikan teknik dengan metode chi square attack dapat mengestimasi atau memperkirakan panjang pesan yang disisipi dalam suatu objek gambar.  Pada tahap uji gambar acak diperoleh hasil chi square 0,60021 yang berarti 60 persen peluang adanya pesan yang disisipkan dalam gambar dan sebesar 0,09999 ataupun sebesar 0,10001 yang berarti 9 persen atau terdapat 10 persen peluang adanya pesan yang disisipkan atau dapat diartikan gambar tersebut tidak disisipi suatu pesan atau data.
METODE SPEOS (STIMULASI PIJAT ENDORPHIN, OKSITOSIN, DAN SUGESTIF) DALAM MENINGKATKAN PRODUKSI ASI IBU POST PARTUM
Authors: Arsi Ranida , Rejeki Sri , Zulfa Achmad
Published: June 2021

Background: Breast milk is the best food that babies need in the first 6 months of life. The success of exclusive breastfeeding is determined at the beginning of offering ASI on the first day of birth. Exclusive breastfeeding can be constrained by the limited production of breast milk. The SPEOS methods is an alternative to help increase breastfeeding. The SPEOS (Endorphin, Oxytocin, and Suggestive Massage Stimulation) methods is a combination of endorpine, oxytocin, and suggestive massage stimulation carried out sequentially which will feel relaxation that stimulates the brain to release endorphin, prolactin and oxytocin hormones, so that breast milk becomes smooth. In addition, it provides comfort to mothers, increases mother's confidence and removes blockages so that obstacles in breastfeeding can be resolved properly.
Objective: To determine the effectiveness of the SPEOS methods in increasing breast milk production in post partum mothers.
Method: A literature review through a review of nursing articles to identify SPEOS methods in increasing breast milk production. The databases used are Scopus, Medica Local Update, One Search and Google Schoolar. The journal source is obtained using a prism flow diagram as the database search flow. The article inclusion criteria used were articles related to the SPEOS methods and breast milk production in post partum mothers, articles in English and Indonesian, articles published in 2010 to 2020, and full text articles while the exclusion criteria were articles published over the past 10 years, the use of foreign languages other than English and Indonesian, not intervention studies and articles that are not full text. There were 7 articles that met the inclusion and exclusion criteria requirements.
Results: This literature review shows that the SPEOS methods (Endorphin, Oxytocin, and Suggestive Massage Stimulation) effective in increasing breast milk production in post partum mothers.
Conclusion: the SPEOS methods (Endorphin, Oxytocin, and Suggestive Massage Stimulation) effective in increasing breast milk production in post partum mothers.
Effect of Jujube Extract on Acetylcholinesterase Activity and Oxidative Stress in Morphine-treated Male Rats
Authors:   Department of Biology, Faculty of Basic Science, Universiry of Mazandaran, Babolsar, Iran., Haratian Zahra , Seyedalipour Bagher ,   Department of Molecular and Cell Biology, Faculty of Basic Science, Universiry of Mazandaran, Babolsar, Iran., Valizadegan Farhad ,   Department of Biology, Faculty of Basic Science, Universiry of Mazandaran, Babolsar, Iran.
Published: June 2021

Background: One of the mechanisms associated with morphine neurotoxicity is oxidative stress. Jujube fruit extract may reduce oxidative stress due to its antioxidant properties. Objective: This study aims to investigate the protective effect of jujube fruit extract on the Acetylcholinesterase (AchE) activity and oxidative stress in the cortex and serum of morphine-treated male rats. Materials and Methods: In this experimental study, 42 male Wistar rats were randomly divided into six groups of 7 which were given oral administration of jujube extract (100 and 200 mg/kg) and intraperitoneal injection of 0.5 mg/kg morphine for 30 days. After blood collection, separation of the serum, and homogenization of brain tissue, the activities of Catalase (CAT), AchE, and Superoxide Dismutase (SOD) enzymes were assessed. Collected data were analyzed using one-way ANOVA. Results: Oral administration of jujube extract at doses of 100 and 200 mg/kg significantly increased the activity of AchE, CAT, and SOD in the serum and cortex of rats compared to morphine injection (P<0.01). Oral administration of 200 mg/kg jujube extract plus morphine injection significantly increased the activity of cortical AchE compared to morphine injection alone (P<0.01). Conclusion: Jujube extract can prevent the side effects of morphine in the cortex by increasing antioxidant activity.
The Ophthalmological Manifestations of Various Inborn Errors of Metabolism: A Narrative Review
Authors:   Eye Research Center, Guilan University of Medical Sciences, Rasht, Iran., Medghalchi Abdolreza , Hassanzadeh Rad Afagh ,   Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran., Dalili Setila ,   Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Published: June 2021

Context: Inborn errors of metabolism or Inherited Metabolic Disorders (IMD) are a class of genetic disorders that occur because of single-gene defects. Evidence Acquisition: In this narrative review article, the authors searched Institute for Scientific Information (ISI), Web of Science, PubMed, and Google Scholar for the relevant evidence. Results: The ocular manifestations of IMDs can be distinguished in different diseases such as Albinism, Cystinosis, Homocystinuria, and Sulfite oxidize deficiency, Mannosidosis, Fucosidosis, Sialidosis, etc. Conclusions: Due to the direct toxic mechanisms of abnormal metabolites on eyes and regarding the effect of eye monitoring on the follow-up, management, and treatment, a detailed ophthalmological assessment is essential.
Pancytopenia as a Presentation of Iron Deficiency: A Case Report
Authors:   Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran., Karami Hossein , Naderisorki Mohammad ,   Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran., Ghasemi Maryam ,   Immunogenetics Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Ghazaiean Mobin ,   Student Research Committe, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Published: June 2021

One of the most common nutritional deficiencies worldwide is iron deficiency. Fatigue, pallor, vertigo, dyspnea, cold intolerance, lethargy, palpitation, headache, and the pallor of the mucous membranes or nail beds are the most frequent symptoms and signs of iron deficiency. Thrombocytosis is commonly observed in iron deficiency anemia; it seems that erythropoietin plays the main role in this respect. Furthermore, thrombocytopenia and even leukopenia have been reported in iron deficiency; however, pancytopenia is a very rare condition. In this report, we presented two unusual cases of pancytopenia due to severe iron deficiency that improved after treatment with oral iron supplements. Iron deficiency anemia, if sufficiently severe, may be associated with reduced platelet and leukocyte counts. Accordingly, this condition should be considered as a differential diagnosis in all patients with pancytopenia.
Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi
Authors: ALTINBAŞ Burçin , GÜVENÇ BAYRAM Gökçen , YALÇIN Murat
Published: June 2021

Merkezi sinir sistemi içerisinde nörotransmitter ve nöromodülatör etkiye sahip histamin, davranış durumunun, biyolojik ritmin, vücut ağırlığının, enerji metabolizmasının, termoregülasyonun, sıvı dengesinin, stresin ve üremenin düzenlenmesinde anahtar role sahiptir. Histaminin merkezi akut enjeksiyonlarının hipotalamo-hipofizer-gonadal (HPG) aks içerisinde etkili olduğunu ve histaminin merkezi H1 ve H2 reseptör-lerinin bu etkiye aracılık ettiğini gösterdik. Fakat çalışmalarda, histaminin ve histamin reseptör antagonistlerinin uzun süreli merkezi tedavilerinin HPG aks içerisindeki etkilerine dair açıklayıcı bir bilgi bulunmamaktadır. Çalışmada, kronik olarak intraserebroventriküler (i.s.v.) enjekte edilen histamin ve antagonistlerinin hipotalamo-hipofizer-gonadal (HPG) aksta rol oynayan, gonadotropin salgılatıcı hormonun (GnRH), folikül stimüle edici hormonun (FSH), lüteinleştirici hormonun (LH) ve testosteron hormonunun plazma seviyelerine etkileri araştırılmıştır. Çalışma Sprague-Dawley ırkı sıçanlarda gerçekleştirilmiştir. Histamin (100 nmol), histaminerjik H1 reseptör antagonisti klorfeni-ramin (100 nmol), histaminerjik H2 reseptör antagonisti ranitidin (100 nmol) veya histaminerjik H3/H4 reseptör antagonisti tiyoperamid (100 nmol) i.s.v. olarak 7 gün boyunca enjekte edilmiştir. Histamin ve antagonistlerinin kronik enjeksiyonu GnRH’nın plazma seviyelerinde anlamlı bir fark oluşturmamıştır. Kronik histamin veya klorfeniramin tedavisi sonucu plazma FSH seviyelerinde artış (p
Production académique et éducative d’un étudiant à la maîtrise en EPT OF IFAP Macapá, Amapá, Amazônia, Brésil
Authors: Viana Valderi Nascimento , Fecury Amanda Alves , Oliveira Euzébio de , Dendasck Carla Viana , Dias Claudio Alberto Gellis de Mattos
Published: June 2021

La production scientifique dans les cours de premier cycle et d’études supérieures a son importance pour la construction d’une nouvelle façon de penser de l’étudiant. Le Master professionnel en formation professionnelle en réseau national (ProfEPT) réunit le contenu disciplinaire, les connaissances pédagogiques et la production académique finale et les relie à des situations réelles de pratique éducative, et le travail final peut être présenté de différentes manières (articles, livres, produits éducatifs). La production académique, tant du conseiller que du guide, en plus de l’importance liée à la diffusion scientifique, a du poids dans l’évaluation du programme et aussi dans son maintien. L’objectif de ce travail est de montrer quantitativement la production académique et éducative d’un étudiant à la maîtrise en enseignement professionnel et technologique (EPT) de l’Institut d’éducation, de science et de technologie (PIPT) de Macapá, Amapá, Amazônia, Brésil. Au cours de la maîtrise, la production scientifique sous diverses formes s’est avérée nécessaire au cours du processus de formation. L’union de la théorie avec la pratique de l’écriture, a facilité la production de la thèse qui devrait être présentée à la fin du cours. Grâce au processus d’organisation, la planification des idées a abouti à une nouvelle pensée structurée selon les normes de l’académie, mais cela ne se limite pas à cet espace et à ces normes. La production pendant la maîtrise vise à contribuer à la fois quantitativement et qualitativement à la production scientifique de la région nord, en l’impactant positivement sur celle-ci et le programme de maîtrise. En plus de l’importance de la contribution de la création et de la diffusion scientifiques, les productions ont tendance à avoir un impact positif sur l’évaluation et le maintien du programme PROFEPT-PIPT, réalisé par CAPES.
ПРИНЦИПИ ПРОЄКТНО-ОРІЄНТОВАНОГО УПРАВЛІННЯ ІННОВАЦІЙНИМ РОЗВИТКОМ НАЦІОНАЛЬНОЇ ЕКОНОМІКИ
Authors: Старченко Григорій
Published: June 2021

У статті виокремлена і надана сутність принципів проєктно-орієнтованого управління інноваційним розвитком національної економіки. Зазначено, що одним із способів підвищення конкурентоспроможності національної економіки є робота на випередження, яка полягає у формуванні нових знань та інструментів методології проєктно-орієнтованого управління, яка є цілісним і комплексним підходом щодо управління інноваційним розвитком національної економіки із врахуванням впливу турбулентного зовнішнього середовища. Зазначене обумовило поширення методології проєктного менеджменту на сферу загальноекономічних процесів. Обґрунтовано застосування проєктно-орієнтованого управління як необхідного теоретико-методологічного базису методології проєктно-орієнтованого управління інноваційним розвитком національної економіки. Виділені та показані логічні взаємозв’язки змістовних складових такої методології: знання (інформація, навички, норми, закони, категорії), принципи, процеси, інструменти (методи, техніки, засоби, процедури, прийоми). З урахуванням того, що остання версія стандарту PMBOK буде побудована на принципах, а не на процесах, важливою складовою методології проєктно-орієнтованого управління інноваційним розвитком національної економіки повинні бути принципи. Доведена необхідність застосування принципу двоконтурного управління, який передбачає рекомбінацію принципів механізму управління для двох взаємопов’язаних складових його функціонування окремо: для формування механізму проєктно-орієнтованого управління інноваційним розвитком та його реалізації, з огляду на досягнення цілей проєктів інноваційного розвитку.
ОСОБЛИВОСТІ ЗАСТОСУВАННЯ МЕТОДІВ РИЗИК-МЕНДЖМЕНТУ У СТРАХОВІЙ ДІЯЛЬНОСТІ
Authors: Абдуллаєва Анастасія
Published: June 2021

У даній статті представлено особливості застосування методів ризик-менеджменту в страховій діяльності, а також визначено шляхи зменшення ризиків у страхуванні за допомогою вибору найоптимальнішого варіанту управління страховою компанією. Проаналізовано етапи на яких основана система ризик-менеджменту а також надано для застосування у страховій діяльності альтернативні інструменти передачі ризиків в страхуванні. Представлені методи управління страховими ризиками, дозволять страховим компаніям зменшити кількість непередбачуваних подій на шляху до отримання бажаного результату. У статті наводиться необхідність впровадження механізму управління ризиками, підкреслено основні проблеми розвитку вітчизняного страхового ринку. Надано аналіз сучасного стану страхового ринку в Україні та запропоновано шляхи його покращення.
La educación después de la pandemia: propuestade implementación de un modelo de EducaciónBásica a Distancia
Authors:   Universidad Nacional Autónoma de México, Navarrete Cazales Zaira , Manzanilla Granados Héctor ,   Instituto Politécnico Nacional, Ocaña-Pérez Lorena ,   Universidad Nacional Autónoma de México
Published: June 2021

El cierre de los centros educativos en todo el mundo, provocado por la pandemia de COVID-19, ha obligado a replantearnos el papel de la escuela como un espacio físico, principalmente en lo que corresponde a la educación básica; en este sentido, el artículo presenta una propuesta de Educación Básica a Distancia a partir del análisis de las circunstancias que se están presentado en el terreno educativo derivado de dicha pandemia. Se da respuesta a las preguntas: ¿es posible estructurar un proyecto permanente de educación a distancia para la educación básica? ¿la modalidad a distancia permitiría una mayor inclusión y cobertura en la educación básica? y ¿es viable establecer la modalidad a distancia a partir de la educación básica primaria y secundaria? Se encontró que, en México, hasta la fecha no se ha implementado una modalidad de educación a distancia para el nivel básico de primaria y secundaria con el fin de dar mayor cobertura y apoyo a los alumnos, a pesar de ser una opción viable y probada en otros niveles educativos, por lo que en este texto se presenta una propuesta de Educación Básica a Distancia que pueda dar atención permanente a los alumnos que por distintas razones no asisten a la escuela de manera presencial, así como en casos de crisis como ocurre ahora por la pandemia de SARS-CoV-2.
Approaches in Chinese Interpretation of the Noble Quran
Authors: MA Yuxian , BAİ Yang
Published: June 2021

This research aims to illustrate the trends of interpretation in the Chinese language by explaining the factors that gave rise to them and explain the basis for its approach, the issues of concern or the issues from which their own position was taken. The research found that the social trend, mental orientation and the deviant trend, influenced by external and internal factors, was reflected in the interpretation in Chinese language In China, with the influence of the world's mental currents, his mind ruled in the Ghebis and reduced the position of the age in interpretation and diminished the value of the old interpreters in interpretation and others. The deviant trend was manifested by the influence of the Qadian kins, an intrusion into Chinese-language interpretation.The deviant trend was manifested by the influence of the Kadian artefacts, an intrudent on Chinese interpretations. The trend was followed by this trend on the basis of her beliefs in the Khatamiyat al-Nabah, Al-Jinnah, Nar, Al-Wah and other issues, so that the impact of It is an intruder to the Chinese interpretation, and the author of this trend, based on her beliefs, was reflected in the Khatamiya al-Nabah, Al-Jinna, Al-Nar, Al-Awah and other issues,the impact of the deviation is clearly demonstrated.
Stucco Inscriptions and Ornaments of The Great Seljuk Mihrab of Rey
Authors: Sokhanpardaz Kamran
Published: June 2021

The art and architecture of the Great Seljuk period, known as the Renaissance of Persian Art in Persian studies, left an undeniable effect on the following periods. The art of the Great Seljuk period, influenced by the art of the previous periods, became a source of inspiration for the artworks of later periods. The aim of this article is to introduce the stucco ornaments and inscriptions of the mihrab of Ray, to reveal the important values of the mihrab and thus to provide the opportunity to evaluate the influence area and its power of influence. As a result of our research, it is found that the ornamental composition of the mihrab includes inscriptions, vegetal and geometric decorations. Also, these decorations were made in embossing and hollowly technique. There is no information about the artist of the stucco decorations of the altar. Although there is no date inscription on the mihrab, it is similar to the examples of the Great Seljuk period in terms of general shape and decoration features. Also according to the results of this research, the stucco decorations in this mihrab, It is very similar to the decoration of the first Islamic era of Iran, obtained from Neyshabur excavations, stucco decorations discovered from Samarra Exploration, architectural ornaments of the Qarakhanid period, stucco decorations from the Ghaznavid Period, Anatolian Seljuk Architectural decorations and stucco decorations of the Ilkhanid Period of Iran.
The General Features and Status of the Illumination Art in the Great Seljuk Period
Authors: Sahafiasl Parisa
Published: June 2021

The most important reason for the enrichment of decorative arts (especially illumination art) in Islamic societies in various periods is the prohibition of depiction in Islam. The art of illumination, which was mostly used to decorate the Qur'an in different historical periods of Iran, including the Great Seljuk period, was influenced by the arts of previous periods and became a source of creativity and inspiration for Muslims and sometimes non-Muslim artists in other countries. This research was carried out in order to examine the status and general characteristics of illumination art during the Great Seljuk period. The descriptive-analytical method was used in the research. As a result, during the Great Seljuk period, the Qur'an manuscripts were made of paper instead of leather. The richness of motifs, patterns and colours, the use of various colours and geometric arrangements draw attention to the illuminations of this period. According to the results of this study, the most important illumination examples of the Great Seljuk period were used in the Quran manuscripts. In these manuscripts, it is seen that motifs such as schemes, six and eight-pointed stars and golden circles are used to decorate the headlines (serlevha pages), the heads of the sura, the interlines and zahriye parts. In addition, the illumination samples of the Great Seljuk period positively affected the later periods, especially the Ilkhanid and Memlukid periods, as well as all other arts. Great Seljuk elegant illumination samples with the beauty of their patterns, the order and delicacy of the motifs and the use of colours are masterpieces of Islamic art.
Artistic Employment of Quranic Symbols in Modern Syrian Poetry
Authors: Onur Ahmet
Published: June 2021

Modern poetry has paid attention to artistic symbols, due to the moral hoarding that these symbols carry, which in a brief phrase can refer to a long story or event that the text is not likely to include in its entirety. The symbol fulfills this function, which summarizes the pronunciation and satisfies the meaning. The study dealt with modern Syrian poetry in the first half of the twentieth century until before the free poetry and afterwards, and it was examined by poets such as Omar Abu Risha, Khalil Mardam, Muhammad al-Bazm, Omar Abu Qus and others. The research revealed the Qur’anic symbols that these poets used artistically, taking advantage of the semantic loads that refer to them. Prior to that, the research had drawn attention to the necessity of separating the Qur’anic symbols from the mythical symbols that tend to fiction rather than reality. Some researchers used to say that there are legends in the Qur’an and described some of its stories as myths, so it was necessary to point out the danger of this link that contradicts Islam and the Qur’an, which falsehood cannot approach it from before it or from behind it.
Haj Travelbooks in Tatar Literature and Musa Jarullah’s Haj Travelbook
Authors: Kiraz Seydi
Published: June 2021

The notes kept during the pilgrimage journeys and the observations, impressions and determinations of the authors provided the formation of the type called pilgrimage travelnames. Many examples of this species have been written both in and outside the Anatolian area. Tatar Turks are one of the societies in which writing works with pilgrimage content outside Anatolia has turned into a literary tradition. In this study, the Haj Seyâhatnâma of Musa Jarullah, a Tatar thinker, will be discussed. The manuscript is registered at 06 Mil Yz A 5924 in the National Library Manuscripts Collection. Seyâhatnâma is located on the sheets 1a-28a of a notebook, all of which are 66 sheets. The countries and events on the route are presented with careful observation in the sea route. In the work, many countries such as Saudi Arabia, Yemen, Egypt, England, Russia, India, China, especially Turkey; important figures such as Ataturk, Ibn Saud, Muhammed Asadullah, Karim Khakimov, Ferdinand de Lesseps; important observations about the Suez Canal, the Istanbul Strait, the Maghrib Strait and the Cenup Strait and the holy lands are included.
Army Maintenance Shaping the Local Burgher Community in 18th-Century Helsinki
Authors: Granqvist Juha-Matti
Published: June 2021

This chapter focuses on the town of Helsinki during the construction of Fortress Sveaborg. Founded in 1747 to be the keystone of the Swedish Realm’s eastern defence, Sveaborg was the biggest construction project in the history of the old realm and turned the small Finnish town of Helsinki into a massive building site. The fortress needed massive amounts of construction materials, as well as food, drink and accommodation for its many thousands of soldiers and workers. The article traces the evolution of the Helsinki burgher community during the fortress construction years, arguing that the close and long-lasting interaction between the town and the fortress gave birth to a special ‘military town bourgeoisie’. Guided by the forces of supply and demand, through the process of trial and error, the local burgher community slowly evolved into a shape that was ideal in serving the military.
WAYS TO EXPRESS THE AUTHOR'S MODALITY IN KAZAKH, KYRGYZ AND ENGLISH FICTION WORKS
Authors: ISKAKOVA Gulgul , KOSTA Peter , SHALABAY Berdibay , KABYKENOVICH Shapauov Alibi , KIYAKOVA Raushan
Published: June 2021

The article widely describes the concept of author's modality in the context of linguistic research and provides a brief history of the study of the category of modality in modern linguo-stylistics and text linguistics. Author's modality is considered as a category that plays the role of compiler, organizer of the literary text. The author's modality was also studied as a communicative-pragmatic and subjective assessment category. In such works as Kazakh writer A. Kekilbayev's novel "Aṅızdıṅ aqırı" and Kyrgyz writer Sh. Aitmatov's novel "Kıyamat", famous American writers Theodore Dreiser's novel "Jennie Gerhardt", Oscar Wilde's "The Picture of Dorian Gray" the different ways of expression the category of author's modality were studied, and similarities and differences were identified.
BEDELSİZ SENEDİ KULLANMA SUÇU ÖZELİNDE HUKUK MAHKEMESİ KARARLARININ CEZA MAHKEMESİ KARARLARINA ETKİSİ
Authors: TAŞ Burak
Published: June 2021

5237 sayılı Türk Ceza Kanunu’nun 156. maddesinde “bedelsiz kalmış bir senedi kullanan kimseye, şikayet üzerine, altı aydan iki yıla kadar hapis ve adlî para cezası verilir” şeklinde düzenlenen bedelsiz senedi kullanma suçu bağlamında ceza mahkemeleri ile hukuk mahkemeleri arasında sıkı bir irtibat bulunmaktadır. Bu çalışma kapsamında bedelsiz senedi kullanma suçu özelinde hukuk mahkemesi kararlarının ceza mahkemesi üzerindeki etkisi incelenmiştir. Öncelikle bekletici sorun ve nisbi muhakeme hakkında genel olarak bilgi verilmiş ardından ceza mahkemesi tarafından bekletici sorun sayılan hukuk mahkemesi kararının bağlayıcılığı hususu irdelenmiştir. Zorunlu olmadığı halde ihtiyaren bekletici sorun sayılan hukuk mahkemesi kararının ceza mahkemesini kural olarak bağlaması gerektiği sonucuna ulaşılmıştır. Ardından iki mahkemede görülen benzer içerikli davaların derdest olup olmaması noktasında çeşitli ihtimaller değerlendirilmiştir. Derdest olan yargılamalarda senet yargılamalarında uzman olan hukuk mahkemesi kararının beklenmesi gerektiği, bedelsiz senedi kullanma suçunun ispatının senetle ispat kuralına tabi olmasına yönelik ilgili Yargıtay kararları ile temellendirilmiştir. Bir hukuk davasının derdest olmaması ihtimalinde ise ceza mahkemesinin hukuk yargısında geçerli senetle ispat kuralı uyarınca nisbi muhakeme yoluna başvurması gerektiği sonucuna ulaşılmıştır.
Self-injury and suicide attempt in incarcerated women: prevalence and risk factors
Authors: Carvalho Eronyce Rayka de Oliveira , Mateus Karla Santos , Lima Kaline da Silva , Silva Jeferson Barbosa , Uchida Ricardo Riyoiti
Published: June 2021

Purpose: To assess the prevalence and risk factors for self-injury and suicide attempt in prison in a sample composed of 186 female inmates. Methods: Sociodemographic data, measures of depression, self-destructive behavior, suicide attempt, and other specific questions related to the reality in the prison environment were collected. Results: Self-injury and suicide attempt before incarceration was reported by 11.3% and 35.5% of the sample, respectively. During imprisonment, a prevalence of 29% and 18.8% for self-injury and suicide attempt, respectively, was observed. Multiple binary logistic regression identified the following risk factors for self-injury: age <32 years, depressive symptoms, history of torture at the time of the arrest, aggression in prison, and sexually transmitted infection. Conversely, the risk factors for suicide attempt were depressive symptoms, self-injury history, aggression in prison, and sexually transmitted infection. Conclusion: This study confirmed the high prevalence of self-harm and suicide attempts in female prisoners. Specific screening tools and the institution of public policies to assess and provide mental health care for incarcerated people in Brazil are needed.
Sonhos de preceptores para um programa de residência multiprofissional: Utopias a serem investidas?
Authors: Arnemann Cristiane Trivisiol , Kruse Maria Henriqueta Luce , Silva Maria Elisabeth Kleba da , Terra Marlene Gomes , Mello Amanda de Lemos , Silva Dariane Trivisiol da , Souto Valquíria Toledo
Published: June 2021

Objetivo: analisar os sonhos de preceptores que poderiam ser implementados, com o intuito de contribuir para o fortalecimento de um Programa de Residência Multiprofissional em Saúde (RMS). Método: nosso artigo trata-se de um Estudo Apreciativo Crítico tendo como orientação teórica a Educação Permanente em Saúde (EPS) e seus conceitos atrelados ao teórico social crítico Paulo Freire. Esta pesquisa foi desenvolvida com sete preceptores do Programa de Residência Integrada Multiprofissional do Hospital de Clínicas de Porto Alegre. Os dados foram obtidos em entrevistas e grupos de discussão através de um ciclo DSPD:  Descoberta, Sonho, Planejamento e Destino, após aprovação no Comitê de Ética e Pesquisa. Resultados: com relação aos sonhos dos preceptores, nós destacamos que estes estão direcionados a valorização dos preceptores, ao aproveitamento do residente como recurso humano para o Sistema Único de Saúde (SUS), ao investimento e qualificação da estrutura pedagógica dos programas de residência e ampliação dos campos de formação do residente. Além disso, identificou-se sonhos que podem ser exequíveis por meio de iniciativas ou da intervenção de preceptores, como estimular as trocas interprofissionais e entre as diferentes ênfases dentro de um mesmo programa, ou entre diferentes programas de residência. Conclusão: observamos que os preceptores trouxeram importantes reflexões sobre suas práticas em seu espaço de trabalho em um processo dialógico, reflexivo e participativo em prol de avanços nas RMS e consequente qualificação da assistência à saúde aos usuários do SUS.
Avaliação da atividade antibacteriana de Punica granatum Linn. (Romã) frente a bactérias orais: Uma revisão integrativa
Authors: Morais Jullierme de Oliveira , Moura Jamile Marinho Bezerra de Oliveira , Santos Pablo de Castro , Almeida Gilmara Celli Maia de
Published: June 2021

Sabe-se que há um grande potencial de plantas medicinais com atividade antibacteriana, tornando-se alternativa para o combate às infecções. Dentre as plantas medicinais destaca-se a Punica granatum Linn.  (Romã), que possui compostos bioativos utilizados para o tratamento de doenças e é utilizada como antisséptico oral para tratar a dor de garganta. Assim, o estudo apresentou como objetivo avaliar a atividade antibacteriana de Punica granatum L. frente a bactérias orais. Para isso, foi realizada uma revisão integrativa, com busca de artigos nas bases de dados PubMed, LILACS e SciELO, utilizando os termos “punica granatum”, “pomegranate”’, “dentistry”, “mouth” e “oral”. Foram selecionados artigos de acordo com os seguintes critérios para inclusão: artigos originais disponíveis na íntegra, publicados nos idiomas inglês, espanhol ou português e publicados nos últimos 10 anos (2010 a 2020). A busca resultou em 126 artigos e após leitura de título e resumo, 16 artigos atenderam aos objetivos da pesquisa e foram incluídos na revisão. Os resultados demonstram que há efeitos antibacterianos principalmente a partir de estudos in vitro (n=13; 81,25%), com ação, na maioria dos estudos da revisão, sobre Streptococcus mutans e outras espécies de Streptococcus orais. Através das análises, constata-se que diferentes formas de utilização do material da planta possuem atividade antibacteriana in vivo e in vitro, em especial o extrato da casca. Portanto, a utilização da romã tem potencial antibacteriano podendo ser uma alternativa para prevenção e terapêutica de infecções orais.
Osteoartrite de joelho e o aspirado de medula óssea como escolha de tratamento - Uma revisão narrativa
Authors: Cunha Paulo Fernando Andrade , Silva Ronald Bispo Barreto da
Published: June 2021

Introdução: Osteoartrite degenerativa (OA) é a principal causa de dor e incapacidade física no mundo, além de estar relacionada com mais de 100 condições reumatológicas e ortopédicas que acometem as articulações e seus tecidos. Objetivo: Compilar, em português, informações sobre o uso do aspirado de medula óssea no tratamento da OA de joelho. Metodologia: Revisão narrativa realizada através de fontes literárias e cientificas, por meio da plataforma US National Library of Medicine (PUBMED). Os Descritores em Ciência da Saúde utilizados foram: knee osteoarthritirs, epidemiology, etiology, pathophysiology, treatment, bone marrow aspirate. Discussão: OA de joelho tem mecanismos que causam inflamação em algum grau nos condrócitos e nas células sinoviais, liberando algumas citocinas que diminuem a síntese de colágeno, além de estimular mediadores catabólicos, causando apoptose dos condrócitos. Assim, o aspirado de medula óssea (BMA) surge como uma terapia celular inovadora, já que as suas células-tronco mesenquimais (MSC) tem um grande potencial imunomodulador, apesar de seus mecanismos ainda não serem completamente compreendidos. Conclusão: novas opções terapêuticas, como as MSC obtidas por BMA, surgem para suprir os espaços deixados pelos tratamentos mais usados atualmente, devido a sua interação imunomoduladora. De certo que existem ainda lacunas sobre seus mecanismos, sendo necessários mais estudos acerca do tema, a fim de consolidá-lo como um tratamento totalmente viável para OA, como pode-se concluir dos estudos promissores existentes.
A influência dos processos neuropsicológicos no aprendizado da leitura em crianças com dislexia
Authors: Campos Beatriz Costa , Vieira Gabriel Santos , Costa Leidianny Kelly da , Barbosa Rosemary Pereira Costa e
Published: June 2021

O objetivo deste artigo é descrever a influência dos processos neuropsicológicos influenciam no aprendizado da leitura de crianças com dislexia, a partir de uma revisão bibliográfica sobre o tema. Nesse percurso, são examinadas diversas influências socioambientais relacionadas às dificuldades específicas de aprendizagem de leitura, como o sistema de ensino e o contexto sociofamiliar. O trabalho contribui academicamente com a compreensão do transtorno, mostrando como os aspectos biológicos, cognitivos e sociais interferem no processo da dislexia e enfatizando como uma intervenção bem-sucedida depende de uma avaliação criteriosa e multidimensional desses fatores relacionados às dislexias de desenvolvimento.
Percepção das mães na utilização de métodos não farmacológicos para alívio da dor em lactentes
Authors: Pires Carolina Cardoso , Klock Patricia , Costa Roberta , Roque Ariane Thaise Frello , Sonaglio Bianca Bertotti , Santos Mariana Medeiros Sell dos
Published: June 2021

O objetivo do estudo foi compreender quais as percepções atribuídas pelos pais em relação ao manejo da dor durante a vacinação de seu filho, em uma clínica privada de vacinação do município de Florianópolis. Trata-se de uma pesquisa com abordagem qualitativa, através da Teoria Fundamentada em Dados. Os dados foram coletados com 10 mães no período de junho a agosto de 2019, por meio de entrevistas semi-estruturadas, gravadas e individuais em uma clínica de imunização privada localizada no município de Florianópolis/SC. Emergiram como resultados três categorias que fomentam o fenômeno central da pesquisa “Percepção das mães ao utilizar a amamentação como método não farmacológico para alívio da dor em crianças submetidas à vacinação”. Através desse estudo, podemos identificar que os métodos não farmacológicos para alívio da dor, por mais que repercutem em satisfação e diminuição da angústia materna durante este momento, ainda são pouco utilizados na prática clínica. Conclui-se que tais métodos ainda são poucos estudados, apesar de possuírem grande valia para o alívio da dor e de traumas para os lactentes e seus respectivos pais e/ou cuidadores. Devendo-se valorizar a relevância do enfermeiro no contexto da vacinação, uma vez que, seus conhecimentos práticos-teóricos são peças fundamentais para que se obtenha o sucesso no manejo da dor.