bluuebunny/crossref_metadata_2025 huggingface dataset:
Смысложизненные ориентации, коммуникативные и мотивационные характеристики обучающихся центров по работе с одаренными детьми
Authors: Дикая Людмила А. , Рыжова Виктория С.
Published: February 2025

Introduction. This paper is the first to examine the psychological characteristics of students studying at gifted education centers of various types – basic and supplementary education. The aim of the study is to analyze the relationship between meaning-in-life orientations and academic motivation and communicative characteristics of students studying at gifted education centers and secondary schools. Methods. The study population comprised 280 students of the Specialized Educational Scientific Center of the Southern Federal District (SESC SFD) (n = 54), the Sirius Educational Center (n = 75) and secondary schools in Rostov-on-Don (n = 150) aged from 12 to 18 years (mean age = 15.3 years), of whom 157 were females and 123 were males. The psychological testing method was used. The diagnostic tools included the Meaning-in-Life Orientations test (MLO) by D. A. Leont'ev (Leont'ev, 2003), the test of the Structure of Schoolchildren’s Educational Motivation by M. V. Matyukhina (Matyukhina, 1984), and the test of Self-Regulation and Success of Interpersonal Communication by V. N. Kunitsyna (Kunitsyna, Kazarinova, Pogol'sha, 2001). Data processing was performed using mathematical statistics using the R 4.1.3 programming language. Results. Compared to school students, 21% of whom have a high level of meaningfulness of life, students studying at gifted education centers, 40% of whom have a high level of meaningfulness of life, have higher rates of academic motivation. Significant differences were found in cognitive motivation, achievement motivation, motivation for self-development and a student’s position in the groups of students with low and high rates of meaningfulness of life. Meaning-in-life orientations were positively related to characteristics that facilitate communication and negatively related to characteristics that complicate communication. Studying in Sirius significantly increases the likelihood that students achieve a high level of success in life. Discussion. Compared to secondary school students, those studying at gifted education centers have a higher level of meaningfulness of life. Communication characteristics depend more on the level of meaningfulness of life than on the type of educational institution. Based on the research results, methodological recommendations were developed for teachers and psychologists who work at gifted education centers using the SESC and Sirius models.
Efeito da abundância de macroalgas sobre a condição corporal de peixes marinhos no rio grande do norte, brasil
Authors:   , Marques Alexandre de Oliveira
Published: February 2025

Bancos de macroalgas em ambientes marinhos podem fornecer abrigo e alimento para peixes e
outros organismos, podendo influenciar na condição corporal dos indivíduos presentes nesses
ambientes. Sendo assim importante entender a ação da abundância de algas marinhas sobre o
estado fisiológico de peixes. Assim, o presente estudo teve como objetivo avaliar o efeito da
abundância de macroalgas sobre a condição corporal de peixes marinhos. Diante disso, foram
realizados arrastos de fundo bimestrais em zonas costeiras dos municípios de Baía Formosa e
Porto do Mangue na costa leste e norte, respectivamente, do estado do RN. Os arrastos de fundo
foram realizados com auxílio de portas do tipo camaroeiro e tiveram duração de 20 minutos
cada. Posteriormente, foram coletadas amostras de água de fundo para análise de fósforo total,
carbono total, nitrogênio total, oxigênio dissolvido e salinidade, além de ter sido verificado “in
loco” a temperatura de fundo e superfície, pH e transparência. Foi coletada amostra de solo para
análise de matéria orgânica. O material biológico coletado foi separado, sendo os peixes
armazenados em caixas isotérmicas com gelo e as algas somente pesadas em cada arrasto. Em
laboratório, os peixes foram identificados e tiveram seu comprimento padrão e peso total
mensurados. A abundância de algas foi um fator importante nas variáveis amostradas, sendo
que foi verificado um incremento na densidade de algas durante o período chuvoso em ambos
locais de coleta. E foram utilizadas técnicas de estatística multivariada para determinação do
efeito de fatores ambientais sobre a condição de 13 espécies de peixe. Diferenças entre períodos
em cada local e condições foram avaliadas pelo pacote estatístico PERMUCO, no software R.
Dentre as 13 espécies avaliadas, seis apresentaram condição melhor durante o período que
apresentou maior abundância de algas. Independentemente do local analisado, houve melhor
condição para período chuvoso, quando também houve maior abundância de macroalgas. Desta
forma, conclui-se que a presença de macroalgas influencia positivamente a condição corporal
para diversas espécies de peixes, disponibilizando alimento e habitats para estas espécies.
Avaliação dos parâmetros inflamatórios em asininos (equus asinus africanus) submetidos a orquiectomia
Authors:   , Rodrigues Luan Aragão
Published: February 2025

Objetivou-se avaliar os parâmetros inflamatórios em asininos (Equus asinus africanus) submetidos a técnica de orquiectomia fechada pelo acesso escrotal e por uma nova abordagem (paraescrotal). Foram utilizados doze asininos divididos em dois grupos: grupo 1(GI) realizou a técnica de orquiectomia através do acesso cirúrgico paraescrotal e, grupo 2 (GII) foi realizada a técnica de orquiectomia pelo acesso escrotal (convencional). As avaliações pós-operatórias consistiram em avaliação macroscópica da ferida cirúrgica, parâmetros hematológicos e do líquido peritoneal, que ocorreram em ambos os grupos nos momentos (M): M0 (antes do procedimento cirúrgico), e os demais momentos após a cirurgia, M12 (doze horas), M24 (vinte e quatro horas), M48 (quarenta e oito horas), M72 (setenta e duas horas), M8D (oito dias) e M16D (dezesseis dias). As feridas cirúrgicas foram avaliadas de acordo com o sangramento e a intensidade do edema escrotal. Foram realizados exames hematológicos, físico-químicos e bioquímicos do líquido peritoneal. As técnicas utilizadas não geraram resposta inflamatória sistêmica importante a ponto de serem detectadas pelo leucograma e dosagem do fibrinogênio. No líquido peritoneal não foram observadas diferenças entre os grupos. A técnica paraescrotal proposta exigiu maior tempo de cirurgia, porém promoveu menor sangramento, menor edema e cicatrização mais rápida.
Desenvolvimento de ferrita de cobalto (CoFe2O4) para aplicações em dispositivos de micro-ondas
Authors:   , Silva Pedro Bruno Nogueira da
Published: February 2025

O constante avanço nas tecnologias de comunicação demanda capacidades maiores em seus sistemas além de conforto. Pesquisas relacionadas a melhorias em dispositivos de comunicação são amplamente realizadas por causa dessa demanda. Essas pesquisas podem ser realizadas na forma estrutural dos dispositivos ou simplesmente na composição material destes. Este trabalho busca avaliar a viabilidade do material Ferrita de Cobalto (CoFe2O4) para composição de um ressoador em uma antena de ressoador dielétrico (DRA), ou antena de ressoador ferrimagnético (FRA), e para composição de um substrato de antena de microfita. O material proposto foi produzido pelo método Sol-Gel. Foi realizada a caracterização eletromagnética do material, assim como simulações no software ANSYS HFSS® e medições de seus parâmetros de reflexão, com auxílio de Analisadores de Rede Vetoriais. As antenas construídas apresentaram resultados satisfatórios, principalmente na aplicação em DRA, com uma perda de retorno de -48,52 dB e uma impedância de entrada de 50,134 – j 0,055 Ω na frequência de ressonância de 7,31 GHz
The Emerging Role of Long Non-Coding RNA 01296 in Human
Malignancies
Authors: Luo Lei , Yang Fan , Fu Xiaoping , Yu Tingting , Tang Wenqian , Xue Juan
Published: February 2025

Long non-coding RNAs (lncRNAs) refer to a group of RNA molecules that
exceed a length of 200 nucleotides and lack the ability to code proteins. Numerous
studies suggest that lncRNAs significantly contribute to the onset and progression of
various forms of cancers. A specific lncRNA, known as long non-coding RNA 01296
(LINC01296), is extensively expressed in human malignancies. The level of
LINC01296 has been shown to correlate with the progression and prognosis of
cancers. Moreover, numerous scientific investigations have provided evidence that the
dysregulation of LINC01296 functioning as a competitive endogenous RNA (ceRNA)
exerts a profound influence on various aspects of cancer cell behavior, including
proliferation, apoptosis, invasion, metastasis, and cell cycle progression, by means of
regulating target genes and signaling pathways. An increasing body of data strongly
suggests that LINC01296 may serve as a valuable biomarker for predicting cancer
prognosis and could represent a promising therapeutic target for cancer intervention.
In this comprehensive review, we summarize the recent advancements in our
understanding of the role, underlying mechanisms, and clinical significance of
LINC01296 in malignant tumors. The findings suggest that LINC01296 may be both a
reliable biomarker and a potential therapeutic target for cancers.
Phytochemicals of Biologically Active Fractions from Silene conoidea Leaves and Stems
Authors: Taleghani Akram , Moghimi Roya , Eghbali Samira
Published: February 2025

Background:

Silene conoidea, a member of the Caryophyllaceae family, is a rare edible
weed in Iran. It possesses various medicinal properties, including insecticidal, antimicrobial, antibacterial,
and allelopathic effects.

Methods:

This study represents the investigation into the phytochemical contents, compounds, and
biological activities of six different fractions [petroleum ether, chloroform, dichloromethane, ethyl
acetate, methanol, and water] obtained from the leaves and stems of this species, with the aim of
developing new natural drugs.

Result:

The methanol fractions of both the leaves and stems exhibited the highest levels of total
phenolic and flavonoid contents and demonstrated strong antioxidant activity in the DPPH free
radical scavenging method, with IC50 values of 5.1± 1.34 and 9.67 ± 0.02 μg/mL, respectively,
surpassing the activity of BHT. Additionally, the chloroform and methanol fractions showed moderate
antimicrobial activity against bacterial strains, with MIC values ranging from 0.0625 to 0.5
mg/ml when compared to gentamicin. The more active fractions [chloroform and methanol] were
further analyzed to identify bioactive compounds. GC-MS analysis detected forty and forty-five
compounds, representing 97.97% and 99.22% of the total composition, in the chloroform fractions
of the leaves and stems, respectively. The main constituents of the leaves were fatty acid derivatives
[54.66%] and terpene derivatives [21.94%], whereas the stems contained terpene derivatives
[40.46%] and hydrocarbon derivatives [31.41%]. LC-ESI-MS analysis of the methanol fractions
revealed the presence of common groups, including flavonoids, steroids, and triterpenoid saponins.
Several bioactive compounds have been identified, including rutin, kaempferol-neohesperidoside
derivative, diosmin, sileneoside, hesperidin, luteolin-di-O-glucoside, orientin-O-glucoside, vitexin-
O-rhamnoside, and swertisin-O-glucoside. Heatmap analysis was conducted to visualize the differences
in metabolite profiles among the samples.

Conclusion:

The analyzed fractions contained compounds with potential pharmacological activities.
Advances in Synthetic Lethality in Potential Oncology Therapeutic
Approaches
Authors: Yang Feifei , Wang Huiyu , Fan Shule , Qiu Huiran , Li Xiangzhi , Shi Guangyao , Li Zihao , Luan Xiaotian , Wu Haigang
Published: February 2025

Synthetic lethality represents a novel paradigm in molecular targeted cancer therapy. In
synthetic lethality, perturbation of one gene alone does not hinder cell viability, yet simultaneous
perturbation of both genes results in a loss of cellular viability. The presence of gene mutations in
cancer cells, as opposed to normal cells, provides an opportunity for targeted therapies that mimic
the effects of the second genetic mutation, enabling selective eradication of cancer cells. Recent
advances in high-throughput screening technologies, such as CRISPR-Cas9 and RNA interference,
have significantly enhanced the identification of synthetic lethal interactions, expanding the potential targets for therapeutic intervention. Challenges in exploiting synthetic lethality for cancer
treatment include the complexities of tumor biology, limited comprehension of synthetic lethal
interactions, drug resistance, and impediments in screening and clinical translation. Emerging
strategies, such as combination therapies and novel drug designs, are being developed to overcome
these obstacles. By virtue of its selective lethality towards cancer cells bearing specific genetic
alterations, targeting synthetic lethal genes holds the promise to provide wider therapeutic windows compared to traditional cytotoxic chemotherapy. This review describes the current state of
synthetic lethality applications in cancer treatment, encompassing both biological and methodological perspectives. It highlights the latest advancements in synthetic lethality with emerging interventional strategies. Furthermore, it explores future directions for research and clinical implementation, aiming to refine and expand the therapeutic potential of synthetic lethality in oncology.
Synthesis and Characterization of 3-S-impurities in Timolol Maleate
Authors: Zhou Dejun , Wang Keyang , Zhang Yuying , Liu Xiaoyue , Mao Xiaoxia
Published: February 2025

Background:

Timolol maleate is clinically used for the treatment of hypertension, angina pectoris, tachycardia, and glaucoma.

Objective:

The aim of this study was to enhance the safe use of timolol maleate and investigate a
synthesis method for 3-S-timolol, a newly identified impurity in timolol API (Active Pharmaceutical Ingredients).

Methods:

(S)-3-(tert-butylamino)propane-1,2-diol (1) was used as a raw material. 3-S-timolol
maleate (7) was synthesized through a five-step reaction. Overall yield was 57.7%, with a purity
of 98%.

Results:

The structure of the target compound was confirmed via analysis of its 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry spectra.

Conclusion:

The synthesis method was straightforward and yielded a high-purity product suitable
for use as a reference in the analysis and identification of timolol maleate-related substances.
Pharmacogenomics and its Role in Cardiovascular Diseases: A Narrative Literature Review
Authors: Kayani Maryam , Sangeetha Gadde Krishna , Sarangi Swapna , G Leela Sarmada , Sharma Shelja , Adedara Victor O , Abdallah Saria , Katz Kristina , Mora Glendalys Rodríguez , Kommuru Sravani , Nazir Zahra
Published: February 2025

Pharmacogenomics has transformed the way we approach the treatment of the most
common diseases worldwide, especially cardiovascular. In this article, we highlight the main
categories of drugs involved in major cardiovascular diseases (CVD), related genetic variability
and their effects on metabolism in each case of contrastive operability. This not only explains
disparities in treatment outcomes but also unfolds customised management based on genomic
studies to improve efficiency and limit side effects. Genetic variations have been identified that
impact the efficacy, safety, and adverse effects of drugs commonly used in the treatment of
CVDs, such as Angiotensin converting Enzyme Inhibitor (ACEI), Angiotensin Receptor Blocker
(ARBs), calcium channel blockers, antiplatelet agents, diuretics, statins, beta-blockers, and anticoagulants.
It discusses the impact of genetic polymorphisms on drug metabolism, efficacy, and
adverse reactions, highlighting the importance of genetic testing in optimizing treatment outcomes.
Pharmacogenomics holds immense potential for revolutionizing the management of
CVDs by enabling personalized medicine approaches tailored to individual genetic profiles.
However, challenges such as clinical implementation, cost-effectiveness, and ethical considerations
need to be addressed to completely incorporate pharmacogenomic testing into standard
clinical practice. Continued research and clinical diligence are required for the utilization of
pharmacogenomics to improve therapeutic outcomes and reduce the burden of CVD globally.
Comprehensive Review of Gestational Diabetes: Pathophysiology,
Pharmacological Management and the Role of Pharmaceutical Care
Authors: Abdu Abdulkadir , Bakrey Hossamaldeen
Published: February 2025

This review addresses the significant part pharmacological treatment plays in treating
gestational diabetes mellitus (GDM), therefore enhancing the results for mother and child. Talking about the frequency and relevance of GDM would help to underline the need for good management. The pathophysiology presents a thorough examination of the fundamental processes,
clarifying how hormonal changes seen during pregnancy lead to insulin resistance and raised
blood sugar levels. The pharmacological treatment approaches for GDM, including insulin
treatment and oral hypoglycemic medications, are investigated in this paper. Taking into consideration the hazards of generating birth deformities and safety data, the paper also evaluates the
safety of the drugs in diabetes pregnancy in order to offer best treatment results. Moreover, the
function of pharmacists in GDM highlights their significance in patient education, ensuring adherence to medication and overseeing therapy in collaboration with multidisciplinary teams. Furthermore, the impact of pharmaceutical care on maternal and neonatal outcomes demonstrates
how pharmaceutical interventions can effectively reduce complications like preeclampsia and
neonatal hypoglycemia, highlighting the importance of personalized medication management.
Finally, the challenges and future directions of GDM address the difficulties in pharmaceutical
care, including patient compliance, healthcare access and emerging treatment methods, calling
for more research and policy initiatives to improve pharmaceutical care frameworks and enhance
health outcomes for both mothers and infants. This comprehensive review highlights the need for
integrated pharmaceutical care in managing GDM and its potential to improve health outcomes
for both mothers and infants.
Quercetin Suppresses Glioma Stem Cells via Activating p16-INK4 Gene Expression
through Epigenetic Regulation
Authors: Li Jianliang , Li Jingchen , Guo Erkun
Published: February 2025

Objectives:

Our study aimed to explore the effects of quercetin on glioma stem cells in patients with
brain tumors.

Methods:

Human glioblastoma cell line, U373MG, or glioma stem cell lines, were treated with quercetin. Cell
viability was determined by using the cell counting kit 8 assays. Cell apoptosis was determined by using the Annexin-V reagent. Western blotting and qPCR were used to detect the protein and mRNA levels of cyclindependent kinase inhibitor 2A (p16INK4a). Chromatin immunoprecipitation analysis was used to determine the
enrichment of H3K27me3 on the p16-INK4 locus with or without quercetin.

Results:

Treatment with quercetin inhibited cell viability and induced cell apoptosis in U373MG cells. Moreover,
treatment with quercetin inhibited the cell viability of four glioma stem cell lines (G3, G10, G15, and G17) from
brain tumor samples at high concentrations while having no obvious effects for the other two glioma stem cell
lines (G9 and G21). Treatment with quercetin increased the mRNA and protein levels of p16- INK4 in glioma
stem cell lines. The study of the underlying mechanism revealed that treatment with quercetin reduced
H3K27me3 (an epigenetic modification to the DNA packaging protein histone H3) levels at the p16-INK4 locus.

Conclusions:

In conclusion, quercetin inhibits glioma cell growth by activating p16-INK4 gene expression
through epigenetic regulation.
Diagnosis of Genital Tuberculosis Unveiled by Utero-Cutaneous Fistula and Superimposed MRSA Infection: A Case Report
Authors: Mangla Mishu , Kumar Naina , Sharma Abhimanyu , Srirambhatla Annapurna , Bukke Nireesha , Chavan Sunil Kumar D. , Roy Subhrajyoti
Published: February 2025

Background:

Both tuberculosis and Methicillin-Resistant Staphylococcus Aureus (MRSA) are known to be notorious for causing fistulas due to their characteristics of persis-tent, difficult-to-treat infections that lead to chronic inflammation, abscess formation, and tissue necrosis. There are several case reports highlighting the invasiveness and potential for fistula formation associated with both tuberculosis and MRSA infections independently, but to the best of our knowledge, this is the first case of a utero-cutaneous fistula caused by chronic infection due to MRSA, superadded on genital tuberculosis.

Case Presentation:

A 35-year-old female, P3L3, visited the gynaecology outpatient depart-ment nine months after her last caesarean section with the complaint of severe pain and blood discharge from the transverse supra-pubic scar during menstruation. On evaluation, she was found to be chronically infected with MRSA and have genital tuberculosis only after histo-pathologic examination of the fistulous tract and tubo-ovarian abscess.

Conclusion:

This case highlights the importance of considering genital tuberculosis in pa-tients with atypical or refractory post-surgical complications and emphasizes the need for a thorough and multidisciplinary approach to its management.
ESCBR: Expert System Enabled Case-based Reasoning Approach in iDDCS for CIND
Authors: Kapruwan Akanksha , Sharma sachin , Goyal Himanshu Rai
Published: February 2025

Background:

CIN is considered as precancerous stage. If we detect CIN stage in its early manifestation
we would be able to avoid cancerous stage. Any gadget with case based reasoning method
could improve the accuracy.

Objective:

Objective of this paper is to combined expert system with CBR. The mycin algorithm
base don backward chaining is to be used to identifying CIN and also to compare the afficacy of
CBR- Aggregate method with CBR GA and CBR-BSR.

Method:

This paper proposes a system consist of two major fundamental component: Expert system
and CBR-ES uses mycin algorithm based on backward chaining.and CBR uses CBR aggregate
and compare it with CBR-GA and CBR-BSR.

Results:

The result shows assuring outcome for early CIN detection using both component . The
mycin algorithm which uses backward chaining method. Second component CBR aggregate
method demonstrated superior performance compared to CBR-GA and CBR-BSR, specially showing
a lower frequency of MAPE percentage.

Conclusion:

The paper concludes that using both Mycin ES and CBR- Aggreate method together
for CIN detetction can significantly reduce error rates, leading to timely and proper medical intervention.
The simultaneous application of both method for mutual confirmation can greatly enhance
the accuracy and reliability of CIN detection.
Two GnRH-mitoxantrone Conjugates, Con-3 and Con-7, Target Endometrial Cancer Cells
Authors: Markatos Christos , Biniari Georgia , Karageorgos Vlasios , Chepurny Oleg G. , Venihaki Maria , Holz George G. , Tselios Theodore , Liapakis George
Published: February 2025

Introduction:

Endometrial cancer is one of the most common gynecological malignancies. Endometrial cancer cells express the gonadotropin-releasing hormone
(GnRH) and its receptor (GnRH-R). Among the various therapeutic approaches for the treatment of endometrial cancer is the use of GnRH
conjugates, such as the AN-152, created by linking the [D-Lys6] GnRH with the cytotoxic doxorubicin through an ester bond. An undesirable
property of these conjugates is their vulnerability to plasma carboxylesterases, which cleave the ester bond to release doxorubicin before reaching
the cancer cells.

Methods:

To overcome this problem, we recently developed the Con-3 and Con-7, which are GnRH analogs conjugated through a disulfide bond with the
cytotoxic mitoxantrone. In this study, we determined the cytotoxic properties of the Con-3 and Con-7 on the Ishikawa endometrial cancer cells,
assuming that their interaction with the GnRH-R of cells exposes the conjugated mitoxantrone to the cellular thioredoxin. The cellular thioredoxin
reduces the disulfide bond of Con-3 & Con-7 to release mitoxantrone, which accumulates in the cancer cells and exerts its cytotoxic actions.

Results:

Indeed, treatment of Ishikawa cells with Con-3, Con-7, or the free unconjugated mitoxantrone increased their apoptosis and decreased their proliferation in a dose- and time-dependent manner, displaying half-maximal inhibitory concentrations (IC50) of 0.64 - 1.15 μM. In specific, the IC50 values on days 2, 3, and 4 were 1.45, 0.64, and 0.83 μΜ, respectively, for Con-3, 0.91, 0.82 μΜ, and 1.00 μΜ, respectively for Con-7 and 1.15, 0.98, 0.78 μM, respectively for mitoxantrone.

Conclusion:

In contrast, the free, mitoxantrone-unconjugated peptides did not affect the proliferation of Ishikawa cells. The Con-3 and Con-7 could put the
basis for the development of a new class of anticancer drugs for endometrial cancer, which will act as “prodrugs” that deliver the cytotoxic
mitoxantrone in a GnRH-R-specific manner.
Innovations in Glycosaminoglycan Delivery: Transforming Joint Health Therapies
Authors: Nisha Mahkesha , Adnan Mohammad , Sakure Kalyani , Ajazuddin  , Jain Parag
Published: February 2025

This thorough analysis looks critically at how glycosaminoglycan (GAG) supports joint
health. It emphasizes the importance of GAG in particular, clarifies the underlying processes linked
to joint pain, and assesses the shortcomings of traditional therapy modalities. Additionally, the research
delves into several traditional approaches, such as injectable GAG therapy and oral supplements,
carefully evaluating the benefits and drawbacks of each. The study then explores novel GAG
drug delivery technologies, acknowledging the urgent need for better treatment approaches. The article
highlights the potential of hydrogel-based systems, liposomal/micellar carriers, and nanoparticles
in addressing current challenges in GAG delivery. These challenges include achieving sustained
release, improving bioavailability, facilitating targeted delivery, and reducing safety concerns
related to biocompatibility. Examining these elements closely and critically, the review seeks to
provide a thorough grasp of the developments, difficulties, and possible breakthroughs in GAG delivery
systems. In the end, this thorough investigation will greatly aid in the improvement of joint
pain therapies. The results imply that by shielding articular joints from erosive effects, early use of
GAG therapy—particularly hyaluronic acid—can reduce joint deterioration associated with arthritis.
Even though GAG-based therapies have shown promise in lowering inflammation and increasing
joint flexibility, further study is required to improve their effectiveness in treating joint pain,
particularly in diseases like osteoarthritis.
Exploring the Penetration of ICT in Rural Primary Schools and How it Influences Teachers, Learners, and the Teaching-learning Process. A Case of
South Africa
Authors: Zenda Rekai
Published: February 2025

Background:

The digital environment possesses a strong influence on the learning environment
and enhances the development and refinement of both teachers' and learners’ preexisting
skills. Essentially, teaching and learning with ICT encourages learner-centered approach
which is associated with more learner involvement and active learning.

Method:

The qualitative interpretive approach was used. A multi-case study design was used.
Purposeful sampling and random sampling techniques were used to select the participants. Data
were collected using in-depth semi-structured interviews with fifteen teachers.

Result:

The findings revealed that teachers lacked ICT skills. Also, the lack of ICT infrastructure
and internet access made it difficult for teachers to help learners use ICT and inhibited active
learning. Thus, training could enable teachers to acquire ICT skills to improve the teachinglearning
process.

Conclusion:

Therefore, making ICT an integral component of the rural primary school education
system is a serious issue for policy-making and planning to enhance learner participation, collaboration,
and communication processes during the teaching-learning process. Furthermore, mechanisms,
such as ICT training, provision of laptops, and improved internet access could provide opportunities
for learners to utilize technology during the teaching-learning process in rural primary
schooling.
Development of STEAM teaching materials for understanding volcano disaster prevention systems
Authors: Sato Shintaro
Published: February 2025

Education around volcanic activity and volcanic disaster prevention systems is important in Japan due to its proximity to the Ring of Fire where there are hundreds of active volcanoes. Knowledge and awareness of what to do during volcanic eruptions has the potential to save lives. The
science of predicting volcanic eruptions is complex and it is therefore difficult to predict eruptions. Therefore, comprehensive knowledge is crucial to ensure effective disaster mitigation strategies are in place. Dr Shintaro Sato, Faculty of Contemporary Human Studies, Kyoto Notre Dame Women’s
University, Japan, leads a team of researchers that is developing STEAM (science, technology, engineering, the arts and maths) teaching materials. The goal is to improve understanding of volcano disaster prevention systems among students and the wider community. This means correctly recognising
disaster information provided by the Japan Meterological Agency and other organisations, and using this information to select actions and make decisions in the event of a disaster. This includes understanding of volcanic observation systems, the reading of numerical data obtained and knowledge
of natural phenomena related to volcanic eruptions. In doing so, Sato believes the content is more likely to have a positive impact on peoples’ lives. Following the development of the teaching materials, the researchers investigated the effectiveness of the content, in part by comparing
the functions of MESH blocks. These include motion, motion-sensing, temperature and humidity, button and LED blocks.
A renewed focus on European competitiveness
Authors: Annette Lucy
Published: February 2025

In a February 2024 speech, on European competitiveness, President of the European Commission Ursula von der Leyen underlined the importance of innovation, research and education. She praised Europe’s resilience in the face of unprecedented challenges, highlighting the crucial
role of research and innovation policies which enabled solutions to be rapidly developed. She said that in the face of ongoing challenges, Europe needs to focus on long-term competitiveness, which is something that may be negatively affected by economic changes. She emphasised that a strong
push for innovation is required. This is a key driver of competitiveness. Von der Leyen mentioned that Europe’s performance on R&I investment has room for improvement, with its global competitors, including the US, Japan, China and South Korea among those who are performing better.
There is a need to boost investment in R&D, with particular focus on R&I. There is also a need to enhance strategies to address declining R&D expenditure. Von der Leyen discussed the results to emerge from an assessment on Horizon 2020, with lessons learned that can be applied
to the EU’s current primary funding programme. Wins included widespread applications and funding, supporting breakthroughs and Nobel prize winners. There is room for improvement when it comes to simplification, expanding participation and dissemination and strengthening collaborations
with other EU initiatives. Von der Leyen highlighted the critical role of education in supporting R&D investment and skills development.
Usability evaluation and proposals for paediatric liquid medication containers
Authors: Murata Mikio
Published: February 2025

Japan’s universal health system allows free access to medical institutions and medical costs for children are often fully covered. While this is a good system, people are not always aware of the concept of self-medication and are less inclined to buy medication over the counter.
The negative impacts of this can be inaccurate administration of medicine for people and their children. Professor Mikio Murata is a licensed pharmacist working on a project to investigate and research pharmaceutical containers, devices and packaging and drug delivery devices. The work will
lead to improved containers, benefiting those administering and receiving medication. As paediatric prescriptions are often prepared by mixing different liquids and then dispensed by adding water to a measuring cup using markings on the liquid container, the process for a parent administering
medicine to their child is cumbersome and it can be difficult to accurately measure medication. There is a need to decipher if the devices in use are fit-for-purpose and if there is a need for new methods for administering certain medicines to ensure the safety of patients. Further issues
relate to the regulation of drug prices, with costs including necessary administration devices and packaging. This means pharmaceutical manufacturers may be reluctant to change packaging or containers after they have been launched due to the production line modifications that would be needed.
Additionally, cost is often prioritised over user convenience as the cost of liquid and ointment containers used in pharmacies is borne by the pharmacy.
A comparative study of medieval Russian pilgrimage travelogues: from the perspective of human relationships and faith
Authors: Misaki Nishikado
Published: February 2025

Pilgrimages have occurred for thousands of years, with pilgrims journeying to places that hold special significance to them as believers of a particular religion. Each year, millions of pilgrims embark on these special journeys. For example, pilgrimages to Mecca in Saudi Arabia. Nishikado
Misaki is a Special Research Fellow based within the Graduate School of Letters at Waseda University in Japan who is interested in what happens during pilgrimages, travellers’ stories and how they behave and interact with one another. In her most recent research project, she is comparing
mediaeval Russian travelogues from the perspective of human relationships and faith. Her main sources for this work are travelogues and academic papers and, alongside reading these, she is also immersing herself in seminars and other activities to absorb a range of ways of academic thinking.
Misaki’s goal is to acquire an interdisciplinary perspective that spans history, literature, anthropology and other fields. By taking the unique approach of encompassing historical and contemporary perspectives, Misaki is working to deepen and connect the analysis of past and present,
generating beneficial knowledge. She is poring over travel records from mediaeval Russia to investigate the relationship between the social background of travellers and the characteristics of their journeys. She is examining these historical sources and comparing them with content gathered
from previous research in the fields of history and literature.
The Role of Joseph de Finance’s Axiological Concept in Opening Youth to the World of Values
Authors: Gavendová Oľga
Published: February 2025

Research and common experience confirm that value orientation of young people has changed fundamentally. Material values have come to the fore and young people do not seem to recognize higher values at all. The subject of the study is the phenomenon of blindness and deafness to higher values. The fact was pointed out by Joseph de Finance, who formulated an axiological conception that offers a solution to this problem. Every human being needs basic values, both material and spiritual, that enable his or her integral development. Each group of values corresponds to certain needs resulting from human nature. However, children or young people often remain attached to material values while they fail to open up to higher values, especially moral ones. The educator must use kairos and help children to take this step. The educator helps those who are blind to certain values to find other similar values that they can recognize. Teachers must help young people to tune in to the wavelength of certain values so they can hear them. The realization of the moral value is of crucial importance since it is through that value that people can develop integrally and find happiness.
Tablet- and Group-Based Multicomponent Cognitive Stimulation for Older Adults With Mild Cognitive Impairment: Single-Group Pilot Study and Protocol for Randomized Controlled Trial (Preprint)
Authors: Jornkokgoud Khanitin , Makmee Pattrawadee , Wongupparaj Peera , Grecucci Alessandro
Published: February 2025

BACKGROUND

Cognitive stimulation therapy is a group-based psychological treatment for people with dementia as well as those with mild cognitive impairment (MCI) and is shown to improve both cognition and quality of life. Previous studies have indicated the potential to benefit from the use of technological devices in group interventions.

OBJECTIVE

The pilot study aimed to assess the effectiveness of a tablet- and group-based multicomponent cognitive stimulation therapy (MCST) for enhancing cognitive functions among older adults with MCI. The following study aims to report the protocol for a trial evaluating whether the MCST program is affecting individuals with MCI.

METHODS

In the first study, 30 individuals with MCI participated in 10 sessions of the tablet- and group-based MCST group. A subsequent protocol study will compare tablet-based MCST, tablet-based cognitive stimulation therapy, and control groups among 93 individuals with MCI. All participants will be recruited from older adults living in semiurban communities. Intervention groups will be facilitated by trained therapists, nurses, or psychologists. The study will be assessed by a pre- and posttest evaluation, including computer-based neuropsychological tests and electroencephalography assessment. The effects of several indicators, such as cognitive functions, behavioral, and emotional, will be analyzed as being indexed by their neurophysiological data.

RESULTS

The pilot study showed significant cognitive improvement (P<.001), reduced depression (P=.002), and decreased state anxiety (P=.001) post intervention. Quality of life remained unchanged (P=.18). The randomized controlled trial study was funded in March 2023. Enrolling began in August 2023 and was completed in December 2023. The data analysis was started, and the results are expected to be published by mid- to late-2025.

CONCLUSIONS

The study is the first tablet-group–based MCST for older adults with MCI in middle-income countries. It will provide deeper insight into participants’ neuropsychological data, thus identifying specific processes underlying physiologically measured positive outcomes. Furthermore, the project will deliver solid and integrative results to mental health professionals in terms of knowledge and guidance for implementing the tablet- and group-based MCST in people with MCI.

CLINICALTRIAL

Thai Clinical Trials Registry TCTR20230829004; https://tinyurl.com/3wuaue3e

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/64465
The Application of Knowledge Graph in the Curriculum Construction of College English Course
Authors: Rao Guohui
Published: February 2025

In the era of rapid information technology development, curriculum construction in education faces new challenges and opportunities. Knowledge graph, a sophisticated semantic network, can effectively integrate and present knowledge in a highly structured manner, which offers a new perspective to teaching reform and curriculum construction. Applying knowledge graph to curriculum construction caters to the need for systematic knowledge integration and requirements of personalized learning, and provides convenient means for dynamic curriculum content update. However,The knowledge graph of the College English course (General English course) also has its own characteristics. Taking the course “College English 1” in the author’s university as an example, it demonstrates the design case of the knowledge graph construction, like multi-module integrated design, association of listening, speaking, reading, writing, and translation skills, incorporation of cultural background. The case also covers the relevance of the knowledge points, managing and operational details of the knowledge graph. Applying knowledge graph to English curriculum construction is beneficial for English learning and teaching, but it is still in the exploratory stage and has some limitations, so it’s necessary to fully explore its potential in future.
Factores determinantes del nivel salarial en la industria automotriz terminal en México
Authors: Sánchez González Karen Estefania
Published: February 2025

Se analizan los factores etapa de establecimiento, región de destino, país de origen y sindicato como determinantes del salario integrado anual de trabajadores sindicalizados, utilizando Contratos Colectivos de Trabajo del año 2019 para 20 empresas armadoras automotrices. Empleamos análisis Kruskal Wallis y pruebas Dunn-Bonferroni para determinar si existieron diferencias salariales. Encontrando que, a partir de la tercera etapa de establecimiento decrecieron los salarios; las regiones centro y norte mostraron salarios altos, occidente y centro-norte bajos; en país de origen las empresas europeas obtuvieron salarios altos y el origen asiático salarios bajos; en sindicatos FESEBS mayores salarios y FNSI salarios bajos.
Las bacterias Firmicutes también respiran: La cadena respiratoria de Bacillus subtilis
Authors: Gutiérrez Cirlos Madrid Emma Berta
Published: February 2025

Bacillus subtilis tiene forma de bastón y se encuentra en sitios como el suelo, el agua o en la comida. Como bacteria Gram positiva, cuenta con una sola membrana, por lo que no tiene un compartimento para el citocromo c, sin embargo, respira con la enzima citocromo c oxidasa. En general, no causa daño al hombre y algunas especies del género contribuyen a mejorar la microbiota intestinal. Esta bacteria es la que más se ha estudiado de las Gram positivas. En esta revisión se hizo una descripción de los diferentes complejos de proteína que integran la cadena transportadora de electrones de B. subtilis, y de las asociaciones que ocurren entre estos complejos. También se describen la regulación de la expresión de ellos y las posibles repercusiones de su funcionamiento y asociaciones con otras proteínas de la membrana celular. Con esta revisión se presenta un panorama general de la cadena respiratoria tan especial de esta bacteria y la importancia de su estudio.
Uso del metaverso en el área de la Salud
Authors: Teodoro Vite Sergio , Cerón Apipilhuasco Ariana , Verdiguel Sotelo Karla
Published: February 2025

Simulation is a tangible and abstract concept, which has permeated a wide range of applications in the basic and applied sciences, giving rise to technologies that allow us to describe, under controlled environments and conditions, physical phenomena,intrinsic and extrinsic properties of the objects that surround us, in a variety of possible scales. In such a way that practically any object of study can be represented by models that evolve over time. Each element of the real world is transported, from a physical space to a virtualized space, where known laws, data from empirical experimentation and historical extrapolations govern.Currently, technology and medicine are interrelated, with electronics, informatics and Information Technologies (ICT’s), which are the set of tools related to the transmission, processing and digital storage of information, have allowed the work of the health professional to have more and better tools for their fundamental purposes.Virtual simulation uses different media to reproduce real conditions in controlled scenarios. It is a didactic strategy, which allows training in a systematic way and faithful to reality of a clinical context, to students in the area of health, which guarantees professional skills in a safe and risk-free way.
Adaptive Automation System
Authors: Krithika M.
Published: February 2025

The paper "Adaptive Automation: Integrated Smart System with HiveX App" focuses on creating a robust automation
solution that enhances energy efficiency and operational control. The HiveX App is at the heart of this system, providing a userfriendly platform for real-time management and monitoring of various smart systems. Through the app, users can seamlessly
interact with different devices and systems, optimizing their operations to conserve energy and improve overall efficiency. By
leveraging real-time data from sensors and automation controls, the HiveX App ensures that electrical appliances, lighting and
environmental systems are activated only when necessary. This dynamic approach significantly reduces power consumption, as
devices are automatically adjusted based on occupancy and environmental conditions. Users can remotely control and monitor
their systems, making energy management more convenient and efficient. The app will give real-time insights to energy usage,
which allows users to track and optimize consumption patterns. Its adaptability ensures that the automation system remains
responsive to changing conditions, making it an essential tool for maintaining energy efficient, smart environments in homes
and businesses.
Analysis of the activities of the monitoring service for the period of radiation diagnostics for 2023 in St. Petersburg
Authors: Trofimova T. N. , Kozlova O. V.
Published: February 2025

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EXPLORING THE IMPACT OF CELEBRITY ENDORSEMENT AND BRAND AWARENESS ON CONSUMER BEHAVIOR: A CASE STUDY OF ES TEH INDONESIA IN KOTA BARU JAMBI
Authors: Sabrina Hanan Laras , Fahdillah Yosi , Pangestu Mira Gustiana
Published: February 2025

This For entrepreneurs, the internet is useful for promoting their business to consumers. The development of digital technology and the growth of the business world in the current era is increasingly heading towards a global direction which makes a company required to establish the right marketing strategy in order to win marketing and be able to compete competitively with competitors. The purpose of this study was to determine the effect of celebrity endorsement and brand awareness on purchasing decisions for Indonesian iced tea, Kota Baru Jambi branch. The population of this study were consumers of Indonesian iced tea, Kota Baru Jambi branch with a sample size of 100 respondents using the lameshow formula. The sampling technique used purposive sampling technique using several criteria. This study uses quantitative methods and the data source used is primary data and data collection using a questionnaire distributed via google form. While the scale in this study uses a Likert scale. The data processing method uses multiple linear regression analysis, determination coefficient, partial t test and simultaneous F test. The results showed that celebrity endorsement had a significant positive effect on purchasing decisions at the Indonesian iced tea branch of the new city of Jambi.Brand awareness has a significant positive effect on purchasing decisions at the Indonesian iced tea branch of the new city of Jambi. And simultaneously celebrity endorsement and brand awareness have an effect on purchasing decisions on Indonesian iced tea in the new city branch of Jambi.