bluuebunny/crossref_metadata_2025 huggingface dataset:
Delayed Puberty and Its Association With Hormonal Changes in Children With Chronic Renal Insufficiency
Authors: Amirkashani Davood , Hooman Nakisa , Shahidzadeh Mohaddese
Published: April 2022

Chronic kidney diseases affect sex hormones, and thus it is now hypothesized abnormal puberty phenomenon in adolescents suffering renal failure. The primary study endpoint was to assess the frequency of disorders related to the clinical incidence of puberty symptoms among children suffering chronic kidney disease, and the secondary endpoint was also to assess the relationship between such manifestations and the serum level of sexual hormones. This cross-sectional study was performed on children with chronic renal failure (more than three months after the onset of the disease). Al baseline characteristics were retrospectively extracted from the hospital recorded files. The pieces of evidence of anemia and acidosis also appeared more in those with delayed puberty. Comparing the groups with delayed puberty and normal puberty showed significantly lower mean body weight and lower mean height in the group with delayed puberty as compared to those with normal status. Comparing serum hormonal conditions between the groups with normal and delayed puberty also showed significantly reduced serum levels of FSH, LH, testosterone, and dihydrotestosterone, as well as increased the serum level of prolactin in the group suffering delayed puberty. The main determinants for delayed puberty in patients suffering chronic renal insufficiency included abnormality in serum hormonal status, along with pieces of evidence of anemia or acidosis. Children with chronic renal insufficiency suffer from delayed puberty. Such phenomenon might be closely linked to abnormal changes in sex hormones due to the nature of renal dysfunction and hemodialysis.
A Case of Non-Progressive Congenital Myopathy: Efficacy and Clinical Outcomes of The Wharton's Jelly Derived Mesenchymal Stem Cell Transplantation
Authors: Azeri Riza , Sun Eda , Karaoz Erdal
Published: April 2022

Non-Progressive Congenital Myopathy is a disease characterized by muscle weakness, and unfortunately, there is no conventional treatment. In the last decade, regenerative medicine practices have become a rising value, and Mesenchymal Stem Cells (MSCs) have fascinating outcomes in regenerative medicine with their high regenerative capacities, their ability to regulate with paracrine secretions, and their immunological properties. Based on our experience in our previous clinical studies, Wharton's-Jelly-derived (WJ-)MSCs are the most suitable source for muscle diseases among all MSC sources. In this study, we evaluated the outcomes of 10 doses of WJ-MSC transplantation to the patient diagnosed with Non-Progressive Congenital Myopathy. A 17-year-old female with a SPEN-1 mutation, Non-Progressive Congenital Myopathy patient received 10 times as 1×10⁶/kg in the intra-arterial, intramuscular and intravenous administration of allogenic WJ-MSC. Before and after the treatment, the patient was followed-up with the upper extremity scale, Vignos lower extremity scale, muscle strength scale, functional independence measure, and evaluation of Serum creatine kinase (CK) levels. Improvement in both upper extremity scale and Vignos lower extremity scales, increasing in muscle strength, and decreasing in CK-level were detected. Although transplantation of WJ-MSC cannot treat any genetic-based diseases, they may benefit in alleviating clinical outcomes of disease. More importantly, WJ-MSC transplantation may offer a better quality of life by alleviating the symptoms of this rare disease with no treatment option that can be provided in conventional methods.
A Man With Urinary Retention by Fecaloma: A Case Report
Authors: Aminiahidashti Hamed , Sazgar Mohammad
Published: April 2022

Fecaloma is a very hard stool often located in the rectum of the sigmoid colon. A 63-year-old man with abdominal distention and urinary retention was admitted to an emergency department. Abdominal CT scans showed a urinary bladder displaced by fecaloma. Fecaloma is an infrequent cause of acute urinary retention, especially in bedridden patients with underlying diseases.
Successful Angioembolization of a Stable Grade 4 Liver Injury
Authors: Ramanathan Shogeta , Mohamad Ikhwan Sani , Ya’acob Mohammad Zawawi , Ramely Rosnelifaizur , Teoh Zhan Huai , Nadarajan Chandran
Published: April 2022

Traumatic liver injury can be classified by grading using American Association with Surgery Trauma (AAST). We presented a case of a 22-year-old female who had a motor vehicle accident and sustained a stable Grade 4 liver injury. An angioembolization was performed by the interventional radiologist team, which successfully occluded all the extravasation of the bleed. If the patient is hemodynamically stable in high grade or bleeding liver injury, a non-invasive technique such as angioembolization could be practiced at the bleeding site to minimize or stop the bleeding.
Assessment of metabolic syndrome in infertile women with polycystic ovary syndrome in a rural population of South India: A crosssectional study
Authors: Kayali Sreelalitha , Chitra Thyagaraju , Kamalanathan Sadishkumar , Nandeesha Hanumanthappa
Published: April 2022

Background: Polycystic ovary syndrome (PCOS) is known to be associated with metabolic syndrome (MS). It is characterised by insulin resistance, hyperinsulinemia, dyslipidemia, obesity and hypertension. Data related to MS in infertile women with PCOS are limited in Indian populations.
Objective: This study aims to compare the prevalence of MS in infertile women with and without PCOS in a rural population in South India.
Materials and Methods: 130 women with PCOS and 130 women without PCOS were enrolled in this cross-sectional study. A detailed history was taken and a physical examination was done for all women. Anthropometric parameters, a glucose tolerance test, fasting glucose / insulin levels, trigylcerides, high-density lipoprotein cholesterol and blood pressure were assessed in all participants. The International Diabetes Federation criteria were applied for assessment of MS.
Results: MS was more prevalent in infertile women with PCOS (42.3%) compared to women without PCOS (19.3%). 56.9% of women with PCOS had low high-density lipoprotein cholesterol levels, 46.2% had high triglycerides, 71.5% had a high waist circumference, 31.5% had high blood pressure and 37.7% had high blood glucose levels. 26.0% of the women with PCOS had a healthy weight, and MS was seen in 6.9% of these women.
Conclusion: The prevalence of MS was higher in women with PCOS in comparison to women without PCOS. Among the women with PCOS, the prevalence of MS increased with age (> 27 yr), body mass index and waist circumference (71.5%), and even healthy women with PCOS contributed to 7% of MS. Hence it becomes necessary to screen all women with PCOS for metabolic profile risk factors at young age itself to prevent long term cardiovascular complications.
Key words: Polycystic ovary syndrome, Metabolic syndrome, Hyperandrogenism, Hormones.
A comparative study of transabdominal and transvaginal ultrasound guidance on consequences of embryo transfer at Mahdiyeh hospital of Tehran in 2020: An RCT
Authors: Geran Malekkheili Paria , Zadehmodarres Shahrzad , Heidar Zahra
Published: April 2022

Background: Infertility is an important problem that affects many couples worldwide. Assisted reproductive technology (ART) helps infertile couples to have offspring. One of the critical parts of ART is embryo transfer (ET).
Objective: To compare the effect of transvaginal and transabdominal ultrasonographyguided ET on ART outcomes.
Materials and Methods: In this randomized clinical trial study, 90 women who were candidates for in vitro fertilization (IVF) referred to Mahdiyeh hospital of Tehran during the yr 2020 were randomly divided into two groups (n = 45/each) of transvaginal and transabdominal ultrasonography-guided ET. The embryos were transferred two-three days after oocyte retrieval. The patient pain, duration and difficulty of the procedure, three-dimensional vision quality and successful pregnancy rate were measured.
Results: In this study, 63.2% of the 45 women who underwent IVF under the guidance of the transvaginal guidance and 36.8% of the 45 women who underwent IVF under the transabdominal guidance had a successful pregnancy, which was not significantly different (p = 0.19). Also, based on other results there was no difference between the two groups in terms of patient pain (p = 0.53), duration (p ≥ 0.50), difficulty of procedures (p ≥ 0.50) and ultrasonography vision; however, the threedimensional vision quality in the transvaginal ultrasonography was better than that in the transabdominal ultrasonography (p < 0.01).
Conclusion: Overall, the ART outcomes in the transvaginal and transabdominal ultrasonography-guided ET were similar, so we suggest that physicians evaluate the patient’s situation, the hospital equipment, and their ability before selecting the type of ultrasonography.
Key words: Transvaginal, Transabdominal, Ultrasound, Embryo transfer, Pregnancy.
Comparing four different methods for the management of ectopic pregnancy: A cross-sectional study
Authors: Shiravani Zahra , Atbaei Sana , Namavar Jahromi Bahia , Hajisafari Tafti Mojgan , Moradi Alamdarloo Shaghayegh , Poordast Tahereh , Noori Adel , Forouhari Sedighe , Sabetian Soudabeh
Published: April 2022

Background: Ectopic pregnancy (EP) is one of the major causes of maternal mortality during the first trimester of pregnancy.
Objective: Four treatment methods for EP including single-dose methotrexate (SD-MTX), double-dose methotrexate, expectant and surgical management were considered.
Materials and Methods: In this cross-sectional study, the clinical characteristics of 365 women aged 15-44 yr who had been diagnosed with EP were reviewed from March 2017 to March 2019 in hospitals affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Receiver operating characteristics curves were plotted to determine the cut-off points for size of ectopic mass and beta-human chorionic gonadotropin (β- hCG) that suitably discriminated between double-dose methotrexate and surgery management.
Results: The most common site of EP was adnexa. According to the receiver operating characteristics analysis, surgery was the best plan for the women with an ectopic mass > 34.50 mm in diameter or with an initial β-hCG level > 6419 mIU/ml. The β-hCG levels in the women successfully treated with SD-MTX were significantly lower than in those with failed treatment (p = 0.02). The SD-MTX group had a higher success rate and significantly shorter duration of hospitalization, and so this was a more effective medical treatment in comparison with the double-dose protocol.
Conclusion: Surgery is proposed as the best option for the cases with large ectopic mass or high β-hCG level. SD-MTX had a higher success rate and shorter hospital stay than the double-dose protocol, and so was found to be an efficient and safe alternative. Further randomized clinical trials with larger sample sizes are recommended to validate the current results.
Key words: Ectopic pregnancy, Methotrexate,
Ureaplasma urealyticum and Mycoplasma genitalium detection and sperm quality: A cross-sectional study in Vietnam
Authors: Tam Le Minh , Nguyen Nguyen Dac , Bach Nguyen Hoang , Quynh Tram Ngo Viet , Quoc Huy Nguyen Vu
Published: April 2022

Background: Ureaplasma urealyticum (U. urealyticum) and Mycoplasma genitalium (M. genitalium) may colonize the male genital tract. However, the negative effects of these bacteria on overall sperm quality, including semen pH, sperm concentration, motility, morphology, and total sperm count remain unclear.
Objective: This study aimed to determine the presence of genital U. urealyticum and M. genitalium in semen and evaluate the effect of these organisms on sperm quality.
Materials and Methods: A cross-sectional study was conducted on 380 men from infertile couples at a tertiary university hospital from July 2017 to June 2018. Semen quality was analyzed according to the World Health Organization 2010 standard, and U. urealyticum and M. genitalium were detected in the semen samples using polymerase chain reaction.
Results: 338 men (88.9%) presented with at least one abnormal semen parameter. The detection rates of U. urealyticum and M. genitalium were 16.05% and 0.79%, respectively. There was no significant difference between the Ureaplasma-positive group and the Ureaplasma-negative group in terms of sperm characteristics. Sperm motility and sperm vitality in the Mycoplasma-positive group were much lower than those in the Mycoplasma-negative group (p = 0.02 and p < 0.001, respectively).
Conclusion: The presence of U. urealyticum in the semen of infertile men did not affect the sperm characteristics. Although the positive rate of M. genitalium was low, colonization by these bacteria was more likely to negatively affect sperm quality.
Key words: Ureaplasma urealyticum, Mycoplasma genitalium, Infertility, Spermatozoa.
Evaluation of CAG repeat length in the androgen receptor gene and polycystic ovary syndrome risk in Iranian women: A case-control study
Authors: Arasteh Hamideh , Araste Fatemeh , Hasan Sheikhha Mohammad , Mehdi Kalantar Seyyed , Farashahi Yazd Ehsan , Reza Ashrafzadeh Hamid , Ghasemi Nasrin
Published: April 2022

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, which affects about 15-20% of women of reproductive age. The most important etiopathogenesis factor in its incidence is hyperandrogenism; over 70 candidate genes are known to be associated with this syndrome, such as the androgen receptor (AR) gene which encodes a steroid receptor and is located on the Xq11-12 chromosome. The N-terminus of exon 1 of AR contains a polymorphic trinucleotide repeat (CAG)n region that encodes glutamine tract. There are some studies showing that shorter AR CAG repeats are significantly related to enhanced AR sensitivity.
Objective: This study investigated the frequency of the polymorphic expansion of the trinucleotide CAG repeats of AR in PCOS.
Materials and Methods: 160 Iranian women aged 17-40 yr participated in this casecontrol study: 80 women as PCOS patients and 80 women as healthy controls according to the Rotterdam criteria. Other similar phenotype factors such as hyperandrogenism were not considered as PCOS. The frequency of polymorphic expansion of CAG trinucleotide repeats in PCOS patients was compared with the frequency in non-PCOS controls in using two primer sets for nested polymerase chain reaction. The polymerase chain reaction products were visualized on polyacrylamide gel and then were confirmed by a sequencing process.
Results: The results did not show a significant correlation between the frequency of CAG repeats in AR and PCOS incidence.
Conclusion: In contrast to some previous reports, the present data showed that the CAG length in PCOS cases did not significantly differ from that of controls. So, the AR (CAG)n does not appear to be a major factor for PCOS in Iranian women.
Key words: Androgen receptor, (CAG)n repeats, Polycystic ovary syndrome.
Bacteriospermia and its association with seminal fluid parameters and infertility in infertile men, Kerman, Iran: A cross-sectional study
Authors: Heidari Pebdeni Parastou , Saffari Fereshteh , Reza Mirshekari Toraj , Ashourzadeh Sareh , Taheri Soodejani Moslem , Ahmadrajabi Roya
Published: April 2022

Background: The role of genital Ureaplasma species, genital Mycoplasma (M) species, and Chlamydia (C.) trachomatis, the most prevalent sexually transmitted bacteria, in male infertility are still not clear. Different reports about the impact of these bacteria on semen quality are controversial.
Objective: This study was proposed to determine the frequency of bacteriospermia in men and investigate the relationship between the presence of these bacteria and semen quality using molecular assay.
Materials and Methods: In this cross-sectional study, 200 semen samples obtained from men attending the research and clinical centers for fertility in Kerman, Iran, between July and December 2019 were analyzed for semen volume, progressive motility, nonprogressive motility, total progressive motility, and viability according to the World Health Organization guidelines. The polymerase chain reaction was used for the detection of related bacteria.
Results: The mean values of volume, progressive motility, non-progressive motility, total progressive motility, and viability were significantly lower in infertile men (p < 0.001). Statistically significant correlations were observed between the presence of M. genitalium and progressive sperm motility, M. hominis and semen volume, Ureaplasma parvum and the sperm normal form, and C. trachomatis and the sperm progressive motility and viability. Logistic regression analysis showed that M. genitalium (OR = 8.06, p < 0.001) and C. trachomatis (OR = 16, p = 0.01) were significantly associated with male infertility.
Conclusion: During the infertility assessment, clinicians should consider the role of C. trachomatis and M. genitalium in male infertility. Screening test particularly for asymptomatic individuals is recommended.
Key words: Chlamydia trachomatis, Infertility, Mycoplasma, Semen analysis, Ureaplasma.
Evaluation of IL-3, IL-5, and IL-6 concentration in the follicular fluid of women with endometriosis: A cross-sectional study
Authors: Ghodsi Mohammad , Hojati Vida , Attaranzadeh Armin , Saifi Bita
Published: April 2022

Background: Endometriosis is associated with abnormal immunologic responses and combined inflammatory and anti-inflammatory conditions.
Objective: This study aims to investigate follicular fluid (FF) concentration of interleukin (IL)-3, IL-5, and IL-6 in women with and without endometriosis.
Materials and Methods: In this cross-sectional study 68 women who were referred to the in vitro fertilization center of Imam Reza hospital in Mashhad during 2018 were selected randomly. Leaves of cytokines in the FF samples were evaluated in the endometriosis and the control group (n = 34/each). The diagnostic accuracy of cytokines and clinical characteristics were evaluated.
Results: IL-3 and IL-6 were significantly changed in the FF of the women with endometriosis compared with the control group (p = 0.04, and p < 0.01, respectively), and the mean concentration of IL-5 in the endometriosis group was lower than in the control group (p = 0.5), but this was not significant. There were significant differences in the menstrual cycle, dyspareunia, and dysmenorrhea between the groups (p < 0.01, p = 0.04, and p = 0.02, respectively). The diagnostic accuracy of IL-3 and IL-6 in the FF was low, with the area under the curve of 0.614 and 0.645, respectively.
Conclusion: Although none of the cytokines had a predictive value for endometriosis, the decreased levels of IL-3 and increased levels of IL-6 in the FF samples of women with endometriosis, and risk factors, including irregular menstrual cycle, dyspareunia, and dysmenorrhea, could be associated with the pathogenesis of this painful disease.
Key words: Interleukin-3, Interleukin-5, Interleukin-6, Follicular fluid, Endometriosis.
Assessment of the effect of serum and follicular fluid vitamin D and glucose on assisted reproductive technique outcome: A cross-sectional study
Authors: Hosseinisadat Robabe , Saeed Lida , Ghasemirad Anis , Habibzadeh Victoria , Safar Heidari Sedigheh
Published: April 2022

Background: Vitamin D and glucose play an important role in the female reproductive system.
Objective: The aim of this study was to assess the effect of serum and follicular fluid vitamin D on assisted reproductive technique (ART) outcomes.
Materials and Methods: 102 infertile women were enrolled in the study. All cases received the routine in vitro fertilization protocol. On the oocyte retrieval day, a sample of their peripheral blood and follicular fluid was obtained to determine the level of vitamin D and glucose. We also evaluated ART outcomes including oocytes, 2 pronucleus and embryo number, implantation, chemical and clinical pregnancy, and abortion rate. Finally, the effect of serum and follicular fluid vitamin D and glucose on the ART outcomes was assessed.
Results: There was no difference in the characteristics, serum vitamin D, follicular fluid vitamin D, fasting blood sugar (FBS), or follicular fluid glucose between the women with vs. without a positive clinical pregnancy. There was no significant difference between the ART outcomes based on vitamin D level. The mean follicular fluid glucose levels in women who were deficient, insufficient and sufficient in vitamin D were 65.20 ± 14.65, 63.47 ± 14.90 and 55.97 ± 15.64, respectively. Follicular fluid glucose was lower in women with sufficient vitamin D levels and this difference was statistically significant (p = 0.01). There was no relationship between the three follicular fluid vitamin D levels and ART outcomes. In women with normal FBS levels, the level of follicular fluid vitamin D was significantly lower than in the women with pre-diabetic FBS status (p < 0.001).
Conclusion: The present study showed that serum vitamin D level, follicular fluid vitamin D level, FBS, and follicular fluid sugar were not predictive parameters for ART outcomes.
Key words: Vitamin D, Glucose, Follicular fluid, Pregnancy, Assisted reproductive techniques.
Correction to “The effect of endometrial injury on pregnancy rate in frozen-thawed embryo transfer: A randomized control trial” [Int J Reprod BioMed 2016; 14: 453-458]
Authors: Aflatoonian Abbas , Baradaran Bagheri Ramesh , Hosseinisadat Robabe
Published: April 2022

This is a Correction to “The effect of endometrial injury on pregnancy rate in frozen-thawed embryo transfer: A randomized control trial” [Int J Reprod BioMed 2016; 14: 453-458] and does not have an abstract. Please download the PDF or view the article HTML.
The Wealth of Nations during the Pandemic: The Vaccine Equity
Authors: GEDİKLİ Ayfer , ERDOĞAN Seyfettin , SHAHBAZ Muhammad
Published: April 2022

Aggressive global dissemination of the coronavirus indicated the urgency of the development of vaccines at an unprecedented rate and scale. The limited production and short supply of vaccines which were reserved mostly for the advanced economies were the greatest problems of 2021. For emerging economies, this timeline will stretch to late 2022 or early 2023. As a part of systematic immunization programs, the development, licensing, and implementation of the vaccines against the Covid-19 virus started to address health service inequalities among countries. While on one hand vaccination is regarded to be one of the most cost-effective interventions in public health during the pandemic, on the other hand, the introduction and sustainable supply of vaccines needed to be supported and ensured by decision-makers and governments. Due to the weak economic conditions of developing countries, they could not provide enough financial and health support to their citizens during this period. However, since the global GDP loss from not inoculating all countries is higher than the cost of manufacturing and distributing vaccines globally, there has been a growing demand to international cooperation to have global vaccination without omitting any countries.
This paper focuses on the economic and social costs and benefits of vaccinations during the Covid-19 pandemic period in advanced, middle, and low-income countries. Accordingly, macroeconomic and social impacts of vaccination will be discussed and some policy suggestions will be put forth to get more benefits from the vaccination both for economic and health outcomes.
Editorial path and the visibility of scientific publications: an exploratory case study on the journal Tchê Química
Authors:   Universidade Estadual Paulista, de Mira Bianca , de Olveira Caroline ,   Universidade Estadual Paulista, Shintaku Milton ,   Instituto Brasileiro de Informação em Ciências e Tecnologia
Published: April 2022

Introduction:Traditionally, the Hard Sciences have journals as their preferred channel for disseminating research results. However, in Brazil these disciplines are predominantly publish in international journals. Thus, it is understandable that the national journals linked to the Rigid Sciences seek international relevance. Objective:The study aims understand the problems related to journals in the field of Chemistry, mainly that concern visibility. Methodology and Results:We chose to select a single journal and analyze its editorial path, through the Journal Ranking provide by the Scimago Journal & Country Rank (SJR), belonging to Scopus. The journal chosen was Tchê Química and its editorial path was analized. The journal remained indexed to the Scopus database from 2011 to 2020. The analyzes included the data provided by the SJR and a citation network built in the VOSviewer software from the citing journals of Tchê Química. Conclusion:It is concluded that the journal has a strong relationship with specific journals and that is ranking results are linked to the citations of these journals and to selfcitations
Acil Servise Başvuran Kronik ve Akut Hastalığı Olan Çocukların Annelerinde Depresyon ve Anksiyete Düzeylerinin Karşılaştırılması
Authors: TEKELİ Aysun , BODUR İlknur , ÖZTÜRK Betül , AKCA ÇAĞLAR Ayla , AÇIKEL Sadettin Burak , ÇOLAK Burçin , KARACAN Can Demir , TUYGUN Nilden
Published: April 2022

Amaç: Ebeveynlerin kronik hastalığı olan çocuğa sahip olması yaşam kalitelerini ve ruhsal durumlarını olumsuz etkilemektedir. Çalışmamızda, kronik hastalığı olan ve önceden sağlıklı akut hastalık ile acil servise başvuran çocukların annelerinde sürekli ve durumluk kaygı düzeyleri ile depresyon düzeylerinin belirlenmesi ve bunu etkileyen faktörlerin değerlendirmesi amaçlanmıştır.

Gereç-Yöntem: Çalışmamız prospektif kesitsel bir çalışmadır. Çocuk Acil Kliniğine önceden sağlıklı ve akut hastalık ile başvuran çocukların anneleri ile kronik hastalığı olan çocukların anneleri çalışmaya dahil edildi. Beck Depresyon Ölçeği (BDÖ) ve Durumluk-Sürekli Kaygı Envanteri (State Trait Anxiety Inventory-STAI) çalışmaya katılan tüm annelere uygulandı. Olguların sosyodemografik verileri sosyodemografik veri toplama formu ile elde edildi. Mann-Whitney-U, Ki-kare ve tek yönlü Anova testleri ile post-hoc analizlerde Tukey HSD istatiksel analizler için kullanıldı.

Bulgular: Çalışmaya 101 (%49) kronik ve 105 (%51) akut hastalığı olan çocukların anneleri dahil edildi. Akut ve kronik hasta grupları arasında sürekli kaygı düzeyi ve BDÖ puanları arasında ise anlamlı farklılık saptanmıştır (sırasıyla p=0,004 ve p=0,001). Durumluk kaygı düzeyi puanlarında anlamlı farklılık saptanmamıştır (p=0,778). Hastalar BDÖ’nin kesme puanı (17 puan) dikkate alınarak muhtemel depresyon açısından ikiye ayrıldığında kronik hastalığı olan çocukların annelerinde akut hastalığı olan çocukların annelerine göre yüksek risk altında oldukları saptanmıştır (χ 2=8,641; p=0,004).

Sonuç: Çalışmamızın sonuçlarında kronik hastalığı olan çocukların annelerinde sürekli kaygı düzeyleri ve depresif belirti oranları önceden sağlıklı ve akut nedenle acil servise başvuran çocuk annelerine göre anlamlı yüksek tespit edilmiştir. Kronik grup ebeveynlerin eğitim ve sosyoekonomik düzeylerinin daha düşük olduğu saptanmıştır. Kronik hastalığı olan çocukların ebeveynleri ruhsal etkilenim açısından değerlendirilmeli, depresyon ve anksiyete gibi bozukluklar tespit edildiğinde psikolojik yardım almaları sağlanmalıdır.
ULTRASOUND ELASTOGRAPHY FINDINGS IN SJÖGREN’S SYNDROME
Authors: GÜNGÖR Özlem , ŞAHİN Kubilay , ÖZTÜRK Cansu , UYSAL RAMADAN Selma , CAN Sevinc , KAŞIKCI Merve
Published: April 2022

Background/Aims: In Sjögren’s syndrome the basic histopathology in all affected organs is progressive lymphocyte infiltration This causes a change in tissue elasticity in the major salivary glands. The purpose of this study is to investigate salivary gland stiffness in primary Sjögren’s syndrome via shear wave elastography.

Material and Methods: According to the 2016 American European Consensus Group criteria, 47 female cases were included in the study as the "patient group" by two rheumatologists. A total of 41 healthy female volunteers, who were in a similar age group and had no symptoms of dry mouth or sicca, and no diagnosis of salivary gland disease, constituted the "control group" of the study .The paired parotid and submandibular glands of all subjects were examined with shear wave elastography. The study was conducted between October 2018-October 2019

Results: In our study, there was a significant difference in both parotid glands' tissue elasticity values in both speed and kPA values in cases with pSS compared to the control group. However, when the submandibular glands were evaluated, no significant difference was found between the two groups. In our study, no relationship was found between the duration of symptoms and elasticity values.

Conclusions :The fact that shear wave velocity (m / sec) and elasticity value (kPA) values are higher in the evaluation of the parotid gland by SWE technique in patients with pSS than the control group makes SWE an easy, non-invasive, and effective imaging method in Sjögren's Syndrome.
Liver cancer understaging in liver transplantation in the current era of radiologic imaging and newer generation locoregional therapies
Authors: Lee Hannah M. , McClish Donna , John Binu V. , Winks Sarah , Clayton Ryan , Albhaisi Somaya , Allawy Allawy , Patel Samarth , Fields Emma C. , Matherly Scott , Strife Brian , Bhati Chandra , Sharma Amit , Sterling Richard K.
Published: April 2022

Background: Discordance in hepatocellular carcinoma (HCC) staging between pre-transplant imaging and explant pathology is associated with an increased risk of recurrence and death. Our aim was to evaluate variables that predicted concordance/discordance in the era of new generation locoregional therapies (LRT) and improved radiologic technology in diagnosis. Methods: A single-center retrospective study was performed on patients who received a liver transplant for HCC between 2008-2019. Pre- and post-LT variables, including type of LRT, downstaging (DS), transplant time period, and radiologic response to LRT, were analyzed for concordance/discordance. Kaplan-Meier analysis was used to assess post-LT survival. Results: Of 146 patients transplanted within Milan Criteria (MC), discordance rates (understaged) were 45%. Discordance was associated with ≥ 3 HCC lesions at diagnosis but not newer generation LRT (transarterial radioembolization/ stereotactic body radiation therapy), traditional LRT or combination. No differences in discordance were seen between transplant periods (2008-2013 vs. 2014-2019), but those within MC in the earlier period had higher concordance rates. A trend was observed between DS and discordance. Conclusion: HCC stage discordance remains common and poorly predictable. Discordance was associated with three or more HCC lesions at the time of diagnosis. Patients within MC transplanted between 2008-2013 was associated with concordance, while a trend was noted between DS and discordance. No other pre- or post- LT variables predicted discordance/ concordance. Discordance was associated with decreased survival.
Repeat laparoscopic anatomical liver resection in a hepatocellular carcinoma patient: a case report
Authors: Igarashi Kazuharu , Mishima Kohei , Ozaki Takahiro , Wakabayashi Go
Published: April 2022

Anatomical resection (AR) has been reported to achieve better long-term outcomes than non-anatomical resection for the treatment of hepatocellular carcinoma (HCC). The surgical feasibility and oncological significance of laparoscopic AR (LAR), especially “subsegment resection”, “cone unit resection”, and repeat LAR for HCC, remain unproven. We present a 67-year-old patient with alcoholic liver cirrhosis and HCC who underwent full LAR three times, focusing on the technical aspects of the Glissonean approach. Repeating LAR for recurrent HCC could be a safe and feasible procedure. However, HCC recurred in the neighboring segment twice, even though pathological vascular invasion and marginal remnants were not confirmed. We should investigate the oncological significance and advancements in subsegmentectomy and cone unit resection, in the future.
Solidification for solid-state lithium batteries with high energy density and long cycle life
Authors: Bi Zhijie , Guo Xiangxin
Published: April 2022

Conventional lithium-ion batteries with inflammable organic liquid electrolytes are required to make a breakthrough regarding their bottlenecks of energy density and safety, as demanded by the ever-increasing development of electric vehicles and grids. In this context, solid-state lithium batteries (SSLBs), which replace liquid electrolytes with solid counterparts, have become a popular research topic due to their excellent potential in the realization of improved energy density and safety. However, in practice, the energy density of SSLBs is limited by the cathode mass loading, electrolyte thickness and anode stability. Moreover, the crucial interfacial issues related to the rigid and heterogeneous solid-solid contacts between the electrolytes and electrodes, including inhomogeneous local potential distributions, sluggish ion transport, side reactions, space charge barriers and stability degradation, severely deteriorate the cycle life of SSLBs. Solidification, which converts a liquid into a solid inside a solid battery, represents a powerful tool to overcome the aforementioned obstacles. The liquid precursors fully wet the interfaces and infiltrate the electrodes, followed by in-situ conformal solidification under certain conditions for the all-in-one construction of cells with highly conducting, closely contacted and sustainable electrode/electrolyte interfaces, thereby enabling high energy density and long cycle life. Therefore, in this review, we address the research progress regarding the latest strategies toward the solidification of the electrolyte layers and the interfaces between the electrodes and electrolytes. The critical challenges and future research directions are proposed for the solidification strategies in SSLBs from both science and engineering perspectives.
Climate-driven shifts in kelp forest composition reduce carbon sequestration potential
Authors: Wright Luka , Pessarrodona Albert , Foggo Andy
Published: April 2022

The potential contribution of kelp forests to blue carbon sinks is currently of great interest but interspecific variance has received no attention. In the Northeast Atlantic, kelp forest composition is changing due to climate-driven poleward range shifts of cold temperate Laminaria digitata and L. hyperborea and warm temperate L. ochroleuca. To understand how this might affect the carbon sequestration potential of these ecosystems, we quantified interspecific differences in carbon export and decomposition alongside changes in detrital photophysiology and biochemistry. We found that while warm temperate kelp exports up to 71% more carbon per plant, it decomposes up to 155% faster than its boreal congeners. Elemental stoichiometry and polyphenolic content cannot fully explain faster carbon turnover, which may be attributable to contrasting tissue toughness or unknown biochemical and structural defences. Faster decomposition causes the detrital photosynthetic apparatus of L. ochroleuca to be overwhelmed after 20 d and lose integrity after 36 d, while detritus of cold temperate species maintains carbon assimilation. Depending on the photoenvironment, detrital photosynthesis could further exacerbate interspecific differences in decomposition via a potential positive feedback loop. Via compositional change such as the predicted prevalence of L. ochroleuca, ocean warming will therefore likely reduce the carbon sequestration potential of these temperate marine forests.
Spatial Analysis of Groundwater Qualities in Vempalle Mandal of YSR District, Andhra Pradesh, India using Geospatial Techniques
Authors: Krupavathi C. , Gowd S. Srinivasa , Kumar P. Ravi , Vijay G. Harish , Kumar B. Pradeep
Published: April 2022

The present study analyses the spatial variations of groundwater qualities in the Mogamureru basin of the Vempalle Mandal, YSR district of Andhra Pradesh, South India. Twenty-two groundwater samples from the post-monsoon season collected in January 2020 and tested in the laboratory for chemical analysis including Carbonate (CO3-), Bicarbonate (HCO3-), Magnesium (Mg2+), Chloride (Cl-), Calcium (Ca2+), Sodium (Na+) and Potassium (K+). The spatial variations in quality parameters mapped using interpolation technique in ArcGIS software. Water Quality Index (WQI) calculated for quality analysis and four groundwater samples classified into very poor category and eighteen samples are unsuitable for drinking purpose. The usage of groundwater for drinking purpose needs a proper water quality treatment for better health implications. The methodology adopted in this study has been found to be effective and can be used to establish strong water quality monitoring network in similar areas.
FİZYOTERAPİ VE REHABİLİTASYON EĞİTİMİ ALAN SON SINIF ÖĞRENCİLERİNİN İŞSİZLİK KAYGILARININ İNCELENMESİ
Authors: ASLAN TELCİ Emine , ŞEKERÖZ Serbay , KARAGÖZ Burak , CAVLAK Uğur , SOYSAL TOMRUK Melda , BAŞKURT Ferdi , ALGUN Candan , KATIRCI KIRMACI Zekiye İpek , YOSMAOĞLU Hayri Baran , RAZAK ÖZDİNÇLER Arzu , YELDAN İpek , SUBAŞI Feryal , ÇINAR Murat Ali , AYHAN Çiğdem
Published: April 2022

Amaç: Ülkemizde eğitim veren fizyoterapi ve rehabilitasyon lisans programlarının sayı ve kontenjanlarının artmasıyla, bu bölümde eğitim gören öğrenciler için iş bulma sorunları ortaya çıkmaya başlamıştır. Çalışmamız Türkiye’de devlet ve vakıf üniversitelerinde eğitim gören fizyoterapi ve rehabilitasyon lisans programı son sınıf öğrencilerinin işsizlik kaygılarını üniversite statüsü ve cinsiyete göre incelemek amacıyla planlandı.
Yöntem: Araştırmamıza Türkiye’de eğitim veren farklı bölgelerden 10 üniversitenin fizyoterapi ve rehabilitasyon lisans programında eğitim gören 845 son sınıf öğrencisi (582 kadın, 263 erkek; ortalama yaş: 22,78±1,52 yıl) dahil edilmiştir. Lisans öğrencilerinin sosyo-demografik bilgileri alındıktan sonra İşsizlik Kaygısı Anketi uygulanmıştır.
Sonuçlar: Çalışmaya katılan fizyoterapi öğrencilerinin işsizlik kaygısı puanları 70 üzerinden 39,90±8,53 şeklinde elde edilmiştir. Devlet üniversitesinde eğitim alan öğrencilerin işsizlik kaygıları (p=0,014), karamsarlık (p=0,001), başarma arzusu (p= 0,0001) ve çözüm arayışlarının (p=0,0001) vakıf üniversitesindeki öğrencilere göre daha yüksek olduğu görülmüştür. Tüm üniversiteler göz önüne alındığında, erkek öğrencilerin başarma arzularının kadın öğrencilere göre daha yüksek olduğu tespit edilmiştir (p=0,014). Akademik başarının işsizlik kaygısı ile pozitif yönde (r=0,072), başarma arzusu (r= -0,99) ve iyimserlik (r= -0,07) ile negatif yönde ilişkisi bulunmuştur.
Tartışma: Çalışmadan elde ettiğimiz sonuçlar devlet üniversitesinde eğitim görmenin, erkek cinsiyetin ve yüksek akademik başarının işsizlik kaygısını artırdığını göstermiştir. Düşük aile gelir düzeyi, toplumlarda erkeğin aileyi geçindirmekle yükümlü birey olarak tanımlanması ve yüksek başarı düzeyi ile toplumda maddi ve manevi olarak daha kabul edilebilir bir birey olma düşüncesi gibi nedenlerin işsizlik kaygı düzeyini artırmış olabileceğini düşünmekteyiz. Fizyoterapistlere yönelik istihdam olanaklarının artırılmasına yönelik girişimlerin, bu popülasyondaki işsizlik kaygısını azaltacağı düşüncesindeyiz.
DETERMINANTS OF TEMPOROMANDIBULAR DYSFUNCTION AND BRUXISM IN ACADEMICIANS
Authors: KILINÇ Hasan Erkan , ÜNVER Banu , SARI Mustafa , TUNÇ Azize Reda , BEK Nilgün
Published: April 2022

Purpose: Temporomandibular dysfunction and bruxism are common problems. Academicians have physical and emotional risk factors that may be associated with temporomandibular dysfunction due to excessive workload and psychological stress. The aim of this study was to reveal the emotional and physical determinants of temporomandibular dysfunction and bruxism in academicians. Methods: Two hundred and ninety-six (217 female and 79 male) academicians working in higher education institutions with a mean age of 35.31 ± 9.20 years, were included in the study. Daily computer time of the participants was questioned. International Physical Activity Questionnaire Short Form (IPAQ), Beck Depression Inventory (BDI), Neck Disability Index (NDI), and Fonseca Anamnestic Index was applied via online surveys. Results: It was demonstrated that 92.9% of the participants were physically inactive or minimal active, 36% showed depressive symptoms, 69.2% had neck disability, 24 % had and moderate-severe temporomandibular dysfunction symptoms, and 44% had bruxism. Bruxers found to have higher BDI (p<0.05) and FAI (p<0.001) levels compared to non-bruxers. Significant positive correlations between FAI and BDI (r=0.316, p<0.001), FAI and NDI (r=0.526, p<0.001), BDI and NDI (r=0.527, p<0.001) was found. Presence of bruxism (β=0.361, p<0.001) and greater NDI (β=0.442, p<0.001) were each uniquely associated with greater FAI score. Daily computer time, IPAQ, and BDI were not associated with FAI score (p>0.05). Conclusion: Key factors of temporomandibular joint dysfunction appear to be physical parameters such as neck disability and bruxism in academics. However, psychological symptoms and physical activity level do not seem to be independent determinants of temporomandibular dysfunction.
Ortaokul Dil Bilgisi Konularının Öğretim Planlaması Sürecinin Öğretmen Görüşlerine Göre İncelenmesi
Authors: ATEŞ Murat , KARATAŞ Ahmet Gürkan , AŞCI Ali Umut
Published: April 2022

Yapılandırmacı yaklaşımla birlikte Türkçe derslerinde yapılan dil bilgisi öğretimi, dört temel dil becerisi etkinlikleri içerisinde öğrencilere sezdirilerek sunulmaktadır. Bu yaklaşımın amacı, öğrencilerde günlük hayatta yetkin bir dil kullanabilme becerisini edindirmek şeklinde belirtilebilir. Türkçe öğretmenlerinin dil bilgisi öğretimine ilişkin görüşlerini tespit etmeyi amaçlayan bu çalışma nitel desenlidir. Yarı yapılandırılmış görüşme formuna verilen cevaplar, içerik analiziyle çözümlenmiştir. Araştırmanın çalışma grubunu Türkiye’de Millî Eğitim Bakanlığında görev yapan Türkçe öğretmenleri oluşturmaktadır. Çalışmada amaçlı örnekleme başvurulmuştur. Bu kapsamda, 31 Türkçe öğretmenine ulaşılmış ve soruları içtenlikle yanıtlamaları istenmiştir. Veriler; mail, Google Formlar aracılığıyla ve yüz yüze toplanmıştır. Verilerin analizi için MAXQDA: Qualitative Data Analysis Software programı kullanılmıştır. Araştırmacılar ve iki alan uzmanı tarafından bağımsız bir şekilde analiz edilen verilere yönelik güvenirliği sağlamak için Miles ve Huberman’ın (2018) formülünden yararlanılmış ve verilerin güvenirlik yüzdesi %81 olarak tespit edilmiştir. Araştırmadan elde edilen sonuçlara göre Türkçe öğretmenlerinin ders kitaplarının haricinde başka kaynaklara da ihtiyaç duyduğu, dil bilgisi konularının sınıf seviyelerine göre dağılımlarının gözden geçirilmesi gerektiği sonuçlarına ulaşılmıştır. Çalışmaya katılan öğretmenlerin çoğunluğu dil bilgisi öğretiminin temel becerilerin haricinde ayrı bir ders zamanında yürütülmesinin daha verimli olduğunu, becerilerle birlikte planlanan dil bilgisi öğretiminin uygun olmadığını ifade etmişlerdir.
Türkiye’de Okul Öncesi Matematik Eğitimi Araştırmalarının Betimsel İçerik Analizi: 2016-2020
Authors: ÇELİK Meryem
Published: April 2022

Matematik eğitiminde araştırma, geçen yüzyılda başlayan nispeten yeni bir bilimsel disiplindir. Daha sonra küçük çocukların matematiksel öğrenimini ve öğretimini araştırmak bu disiplinin bir parçası haline gelmiştir. Küçük çocukların matematiksel anlayışının nasıl geliştirilebileceğine dair derin bilgi edinme amacı, araştırmacıları bu alanda çalışmaya yönlendirmiştir. Matematik eğitiminin tüm alanlarında ilerlemek ve eğitim uygulamasının yararlanabileceği yeni bilgilerin üretilmesine katkıda bulunmak için yüksek kalitede araştırmaların yapılması gereklidir. İlk yıllarda atılan matematik temellerinin daha sonraki başarıyı etkilediğine dair birçok kanıt olduğu için bu tür yüksek kaliteli araştırmalar özellikle erken çocukluk matematik eğitimi için kritiktir. Bu bağlamda çalışmada, Türkiye’de okul öncesi matematik eğitimi alanında 2016-2020 yılları arasında yapılmış olan araştırmaların analizinin yapılması amaçlanmıştır. Betimsel içerik analizi yöntemi ile yapılan araştırmanın örneklemini Türkiye’de okul öncesi matematik becerileri ve eğitimi hakkında 2016-2020 yılları arasında yapılan, ulusal ve uluslararası hakemli dergilerde yayınlanan 66 makale oluşturmaktadır. Yapılan analizler sonucunda, araştırmaların en çok bilişsel özellik belirleme kategorisinde yapıldığı, 2017 yılında daha fazla olmakla birlikte her yıl bu alanda araştırmaların olduğu, çoğunlukla nicel yöntem kullanılarak, başarı testleri tercih edilerek, 31-100 örneklem büyüklüğünde ve çocuklar ile yapıldığı ortaya çıkmıştır.
Helsinki Bildirgesinin Plasebo Evrimi ve Etik
Authors: YILMAZ ÇELİK Sümeyye , KARATAŞ Mehmet
Published: April 2022

Helsinki Bildirgesi 1964 yılında yayımlandığında insanlar üzerindeki tıbbi çalışmalar için hekimlere bir rehber, yapılan değişiklikler ile tanımlanabilir insana ait materyal ve verileri dâhilolmak üzere insanlar üzerindeki tıbbi araştırmalarda hekimlere ve çalışmalarda yer alan diğer katılımcılara yol gösterici olmuştur. İlk kez 1996 yılında Bildirgede geçen plasebo; “kanıtlanmış bir tanı ve tedavi yönteminin bulunmadığı çalışmalarda plasebo kullanımı dışlanmaz” şeklinde yer almıştır. Bildirgenin son halinde ise; “kanıtlanmış tedavi olsa bile araştırılan yöntemin, güvenirliliğini etkinliğini belirlemek için bilimsel çalışma yapmanın zorunlu olduğu durumlarda ve kanıtlanmış en iyi tedavininuygulanmamasının hastaya ilave ciddi veya geri dönüşüz zarar vermeyeceği durumlarda; kanıtlanmış en iyi müdahaleden daha az etkili bir müdahale veya plasebo kullanımı veya müdahalede bulunmama” seçeneklerinin yer aldığını görmekteyiz.Klinik araştırmaların insanların sağlığı için yapılmaya çalışılması elbette önemlidir. Bilimsel bir gereklilik ve mecburiyet içeriyorsa plasebo kullanımı gibi hassas bir uygulamanın da insan deneklere zarar vermeyecek şekilde araştırmalarda yer alması gerekebilir. Ancak, Helsinki Bildirgesinin 2013 yılında yayımlanan son halinde artan plasebo-kanıtlanmış en iyi tedaviyi vermegayretinin içerisinde yoğun bir etik problemin olduğunu görmekteyiz. Bildirgenin tarihsel sürecine bakıldığında ilk yayımlandığı haliyle günümüzdeki son versiyonu arasında plasebo kullanımıyla ilgili olarak ciddi bir evrim geçirmiş olduğu söylenebilir.
Energy Efficient Dim and Dark Cache for Temperature Reduction of Chip
Multiprocessors
Authors: Kulkarni Ashwini , Mahajan Shrinivas P.
Published: April 2022

Background:

For high computation, parallel and distributed processing chip multiprocessors
are widely used. In chip multiprocessors, large on chip cache memories are used for performance
improvement and speedy execution of the task. These cache memories consume 13% to 45%
of the overall power consumed by the entire chip. As chip size shrinks with technology scaling, static
energy consumed by the chip increases. This results in heating and chip malfunctioning. To solve
this problem we apply static energy reduction techniques to Last Level Cache (LLC) to reduce static
energy consumption and thereby chip temperature rise.

Methods:

Static energy reduction is achieved with two methods.
DIM_OLY_SEL Policy:- In this policy, static Energy Reduction is achieved by dimming cache
banks.
DIM_DARK_PAT Policy:- In this method, dimming as well as darkening techniques are used to
save static energy and thereby, temperature reduction.

Results:

With the implementation of DIM_OLY_SEL policy LLC, Temperature Reduction up to
1.4 Kelvin, improvements in EDP (Energy Delay Product) gains up to 28% and leakage energy Saving
up to 23% is observed.
With the implementation of DIM_DARK_PAT, we observed LLC temperature reduction up to 4.7
Kelvin, EDP gain improvement of 33 % and leakage energy saving 23%.

Conclusion:

DIM_OLY_SEL and DIM_DARK_PAT Policies are observed to be very effective
policies for energy saving and chip temperature reduction. Hence, they can be used effectively for
safe chip multiprocessor functioning.