Abstract PS9-37: Hereditary breast and ovarian cancer syndrome (HBOC) diagnosis impacts more the life quality of women than men: A case-control report
Authors: Oliveira Francisca Fernanda Barbosa , de Barros Silva Paulo Goberlanio , Silva-Fernandes Isabelle JoyceLima , Picanço-Albuquerque Clarissa Gondim , Claudia dos Santos Luciano Maria , Bezerra Maria Júlia Barbosa , Sant´anna Rosane Oliveira , Bitencourt Flavio Silveira , Lima Marcos Venicio Alves 
Published: February 2021

INTRODUCTION: HBOC syndrome is directly associated with a variant in BRCA1/2 genes and the diagnosis may increase anxiety and depression levels because of the need for preventive measures. Psychic impacts on women with mutations have been further explored in the literature, although the emotional aspects linked to the diagnosis in male breast cancer is poorly known. AIM: This work aimed to compare the anxiety, depression, and quality of life levels in male and female cancer patients HBOC-suspected, immediately after the result of the genetic test. METHODOLOGY: A retrospective case-control study was carried out with five men matched for age with 39 women, both with National Comprehensive Cancer Network (NCCN) criteria for HBOC. The Hospital Anxiety and Depression (HAD) scale and the WHOQOL-bref quality of life inventory were used. Sociodemographic, clinical, molecular, and psychological data were analyzed using χ2/Fisher's exact and Mann-Whitney, Friedman/Dunn, and Wilcoxon tests (SPSS, 20.0; p &lt;0.05). RESULTS: All patients were &gt;45 years old, all recruited women had breast cancer as the primary tumor and eight of them (20.5%) had ovary cancer. We had two male breast cancer and three prostate cancer Gleason&gt;7. Sociodemographic characteristics did not differ between the genders (p&gt; 0.05). Men had a higher prevalence of pathogenic mutation (p=0,031). Women had a higher prevalence of BRCA1 mutations (p=0,014) while men had of BRCA2 mutation (p=0,001). There was no difference in the anxiety and depression levels immediately after receiving the result, but it was observed that only women had lower quality of life in the physical domain (p=0,048). This domain showed the lowest scores in female patients (p&lt;0,001). Although men have a higher prevalence of the pathogenic mutation in BRCA1/2, the emotional impact is greater in women whose impact on the physical domain may be directly associated with cancer treatment, which may have physical and psychological consequences, negatively affecting the quality of life of these women. CONCLUSION: These results reinforce the need to address the psycho-emotional aspects of women with HBOC, to promote better treatment coping, providing a better quality of life. Research Sponsor: Ministerio da Saude, Brasil (PRONON)

Citation Format: Francisca Fernanda Barbosa Oliveira, Paulo Goberlanio de Barros Silva, Isabelle JoyceLima Silva-Fernandes, Clarissa Gondim Picanço-Albuquerque, Maria Claudia dos Santos Luciano, Maria Júlia Barbosa Bezerra, Rosane Oliveira Sant´anna, Flavio Silveira Bitencourt, Marcos Venicio Alves Lima. Hereditary breast and ovarian cancer syndrome (HBOC) diagnosis impacts more the life quality of women than men: A case-control report [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS9-37.