bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of methanol extract of cloves (Syzigium aromaticum) on Protein Gene Product 9.5 in the testes of rats (Rattus norvegicus) with induced cryptorchidism
Authors: Nufus Faizah Zakiyyatun , Bambang Sektiari Lukiswanto  , Ira Sari Yudaniyanti  , Nove Hidajati  , Eduardus Bimo Aksono Herupradoto  , Budi Utomo
Published: October 2024

This study aimed to know the effect of cloves (Syzigium aromaticum) methanol extracts as an antioxidant on the germ cells of white rats (Rattus norvegicus) with induced cryptorchidism. The subjects of this study were 24 male white rats aged 21 days, who were divided into six groups. Rats were adapted for 5 days, after which cryptorchidism were induced. Cloves extract was given for 18 days and 36 days. On day-19 and day-37, rats were sacrificed and testicles were taken for Protein Gene Product (PGP) 9.5 detection by immunohistochemistry. These groups consisted of negative control group (given distilled water and sham surgery), positive control group (induction of cryptorchidism and given distilled water), and T treatment group (induction of cryptorchidism and given 70mg/kg bw cloves extract. Kruskal-Wallis test indicated a significant difference (p <0.05). The differences between treatments were shown based on the outcome of the Mann-Whitney test. Cloves acted as an antioxidant for cryptorchid testicular germ cells. It could be concluded that administering methanol extract of clove flowers could ameliorate the expression of PGP 9.5 in the testicular germ cells of white rats in a model of unilateral cryptorchidism.
Ölüm Kaygısının Tüketicinin Kendine Hediye Davranışına Etkisinin İncelenmesi: Kırıkkale İlinde Bir Araştırma (Examining The Effect of Death Anxiety on Consumer s Self-Gift Behavior: A Research in Kırıkkale Province)
Authors: Bozacı İbrahim , İşcan Rabia Vildan , Kartal Cihat
Published: October 2024

Amaç–Bireyler kutlama, kendilerini ödüllendirme veya hayal kırıklıklarını giderme gibi amaçlarla ilgi duydukları ürün ve hizmetlerle kendilerine yönelik alışverişler veya tüketimler yapabilmektedir. Ölüm kaygısı ise tüketici davranışlarını etkileyebilen bir duygu olmakla birlikte, bunun kendine hediye davranışına etkisiyle ilgili bulgular kısıtlıdır. Bu araştırmada, ölüm kaygısının kendine hediye davranışına olası etkisinin ortaya konması amaçlanmıştır.Yöntem –Bu araştırma da Kırıkkale ilinde online anket yöntemiyle birincil veriler toplanmıştır. Kolayda örnekleme yöntemiyle seçilen katılımcılara yönelik olarak toplam 336 anket uygulaması yapılmış ve elde edilen veriler SPSS istatistik paket programı kullanılarak analiz edilmiş ve yorumlanmıştır.Bulgular –Elde edilen verilerin analizi neticesinde; ölüm kaygısının bireylerin kendine hediye verme davranışı üzerinde pozitif yönde etkili olduğu tespit edilmiştir. Buna göre ölüm kaygısı; bireyin kendisine yönelik ruh hali pekiştirme/geliştirme, ödüllendirme, hayal kırıklığı giderme ve kutlama olarak adlandırılan kendine hediye davranışı boyutlarını etkilemektedir. Araştırma bulgularının tüketici davranışları yazını ve pazarlamacılar için yararlı olması umulmaktadır. Son olarak araştırma bulguları yorumlanmış ve önerilerde bulunulmuştur. Tartışma –Araştırma bulguları literatür ile benzer şekilde ölüm kaygısının tüketim üzerinde etkili olduğunu; ve tüketimin bir alt alanı olan kendine hediye davranışlarını pozitif yönde etkilediğini göstermektedir. Bu davranışın bir tür ölümle başa çıkma mekanizması olarak işlev gördüğü değerlendirilmektedir. Bu sonuçlar, ölüm kaygısının tüketim davranışları üzerindeki etkilerinin daha iyi anlaşılmasına yardımcı olabilir.
Özel Hastanelerde Bütçeleme Sürecinin Katılımcı Bütçe Üzerine Etkileri: Ankara İli Örneği (Effects of Budgeting Process on Participative Budgeting in Private Hospitals: The Case of Ankara Province)
Authors: Arslan Mehmet , Uygun Sabit
Published: October 2024

Amaç: Araştırmanın amacı, Ankara ilinde faaliyet gösteren özel hastanelerde katılımcı bütçe anlayışının idari çalışanlar açısından değerlendirilmesi; bütçe planlama, bütçe hazırlık ve bütçe uygulama anlayışının katılımcı bütçe üzerindeki etkisi ve bütçe analizin bu etkide düzenleyici rolü değerlendirmektedir.Yöntem:Etik izin onayı alınmış anket formu ile hastanelere başvuru yapılarak araştırma izni alınmıştır. Alınan izin doğrultusunda araştırmaya dâhil edilen personellere yüz yüze görüşmeler yapılarak anket formunu yanıtlamaları sağlanmıştır.Örnekleme yöntemi olarak kolayda örnekleme yöntemi uygulanmış ve 144 anket değerlendirmeye alınmıştır. Araştırmanın düzeyi ve sınırlılıkları göz önünde bulundurulduğunda örneklem çapının anlamlılık düzeyinin (%5), gücünün (%95) ve etki büyüklüğünün (orta düzey: %15) alınmasına karar verilmiştir. Araştırmada üç bağımsız bir düzenleyici ve bir de bağımlı olmak üzere toplam beş değişken bilgisi de kullanılarak örneklem çapı 138 olarak hesaplanmıştır. Hesaplamalar GPower 3.1.9.7 yazılımı kullanılarak yapılmıştır.Temel analizler SPSS ölçüm modeli analizi Amoss’da, yapı ve ayrışma geçerliliği SmartPLS’de ve araştırma modeli analizi SPSS Process Macro uzantısıyla yapılmıştır.Araştırmada elde edilen veriler varyans, DFA, AFA, MTK,Bartlett's Testi, KMO istatistiği,Korelasyon Analizi, t-testi,Cronbach's Alpha katsayısı,Anova ve Tukey testleri kullanılarak değerlendirilmiş ve yorumlanmıştır.Bulgular:Araştırmada regresyon katsayıları incelendiğinde katılımcı bütçe üzerinde bütçe planlama, bütçe hazırlık, bütçe uygulama ve analiz değişkenlerinin etkisinin pozitif ve anlamlı olduğu görülmektedir.Etkileşim teriminin de anlamlı ve negatif yönlü olduğu görülmektedir. Analiz düzeyi arttıkça bütçe planlama ve bütçe uygulamanınkatılımcı bütçe üzerindeki etkisi azalmaktadır.Tartışma: Özel hastanelerde katılımcı bütçe algısı ülkemizde yeterli seviyededeğildir. Bütçe planlama, bütçe hazırlık, bütçe uygulama süreçlerinin katılımcı bütçe üzerine etkisi ve bu etkide bütçe sapma analizinin düzenleyici rolü değerlendirilmiştir. Literatürde hastanelerde bütçe sürecine yönelik çalışmalar değerlendirilse de katılımcı bütçe boyutuyla bir araştırma gözlemlenmemiştir.Bu noktada literatüre önemli ölçüde katkı sağlayacağı düşünülmektedir.
Yiyecek İçecek İşletmelerinde Çatışma: Alaylı-Mektepli Aşçılar Çatışıyor Mu (Conflict in Food and Beverage Businesses: Do Self-Educated and Educated Chefs in Conflict )
Authors: Temizkan Rahman , Çıtak Burak
Published: October 2024

Amaç –Literatür incelendiğinde, günümüzde aşçılık ve gastronomi bölümlerinin sayısının artmasıyla birlikte aşçılık mesleğinde eğitimli aşçıların sayısında önemli derecede bir artışın olduğu görülmekte ve dolayısıyla alaylı ustalardan eğitimli aşçılara doğru bir geçiş sürecinin yaşandığı söylenebilmektedir. Bu durumun sonucu olarak sektörde alaylı-mektepli çatışması görülmeye başlanmıştır. İlgili alan yazın incelemesi sonucunda alaylı-mektepli çatışmasını ele alan başka bir çalışmaya rastlanmamıştır. Bu nedenle çalışmanın temel amacı, yiyecek –içecek işletmelerindeki alaylı-mektepli çatışmasının saptanmasıdır. Bununla birlikte, çatışmanın ne sıklıkla yaşandığının belirlenmesi, sebeplerinin ve sonuçlarının ortaya konulması da çalışmanın diğer alt amaçları arasındadır. Yöntem –Çalışma, 9 alaylı ve 9 mektepli olmak üzere 18 aşçı ile gerçekleştirilmiştir. Çalışmada nitel yöntem benimsenmiş olup veriler katılımcılardan görüşme tekniğiyle elde edilmiştir. Katılımcılardan elde edilen verilerin analiz edilmesi için Maxqda nitel analizprogramından yararlanılmıştır. Bu kapsamda çalışmada içerik amalizi ve betimsel analiz kullanılmıştır.Bulgular –Verilerin analizi sonucunda; çatışmanın aşçılar arasında genellike yaşanan bir durum olduğu ve pratik, teorik, teknik, tecrübe farklılığı ve mesleğe yönelik bakış gibi ana konular etrafında yaşandığı, kök sebeplerinin ise;ego, baskı-engellenme, kendini ispatlama çabası, etik konular, ön yargı-iletişim eksikliği, kıskançlık ve beğenilmeme-yetersiz görme olduğu sonucuna varılmıştır. Ayrıca,çatışmanın her iki grup içinde olumsuz sonuçlar doğurduğu ve bu olumsuz sonuçların ise;işten ayrılma, mesleği bırakma, iş tatminsizliği ve tükenmişlik olduğu saptanmıştır. Tartışma –Çatışma yiyecek-içecek sektöründe hem işgören hem de işletmeler için için ciddi sorunlara yol açabilmektedir. Bu nedenle çatışmanın anlaşılması ve çözülmesi oldukça önemlidir. Bu anlamda çalışma, alaylı-mektepli aşçılar arasındaki çatışmasının derinlemesine anlaşılmasına ve sektördeki iş yerlerindeki dinamiklerin daha iyi yönetilmesine yardımcı olacak bilgilerin sağlanması adına ilgili alanyazına katkı sağlamaktadır.
Lider-Üye Etkileşimi ile Örgütsel Özdeşleşme Algısı Arasındaki İlişkide Algılanan Örgütsel Desteğin Aracılık Rolü (The Mediating Role of Perceived Organizational Support in the Relationship Between Leader-Member Exchange and Organizational Identification Perception)
Authors: Ateş M. Fikret
Published: October 2024

Amaç-Bu çalışma, öğretmenlerinin fikirlerine saygı duyan ve öğretmenlerin kurumlarıyla bütünleşmelerini sağlayabilen eğitim kurumlarında, okul yöneticileri ile öğretmenler arasındaki ilişkilerin kalitesini önemseyen lider-üye etkileşimi yaklaşımının gücüne dikkat çekmek için planlanmıştır. Bu kapsamda çalışmanın amacı, okul müdürleri tarafından sergilenen “Lider Üye Etkileşimi” yaklaşımı ile öğretmenlerin “Örgütsel Özdeşleşme Algısı” arasındaki ilişkide öğretmenlerin “Algılanan Örgütsel Destek” değişkeninin aracılık etkisinin olup olmadığının araştırılmasıdır.Tasarım/Yöntem/Yaklaşım-Araştırma verisi, Haziran-Temmuz 2023 döneminde e-anket yöntemiyle Ankara’daki özel liselerde çalışan öğretmenlerden toplanmıştır. Araştırma ölçeklerinin güvenilirliklerinin için hesaplanan “Cronbach’ın Alfa” katsayılarının bu örneklem için oldukça yüksek oldukları görülmüştür. Araştırmanın hipotezleri ve aracılık etkisinin testinde yapısal eşitlik modellemesi kullanılmıştır.Bulgular-Yapılan analizler neticesinde, “Lider-Üye Etkileşimi” bağımsız değişkeninin “Örgütsel Özdeşleşme Algısı” bağımlı değişkeni üzerindeki etkisinin istatistiksel anlamlılığının olduğu ve pozitif yönlü etkisinin olduğu görülmüştür. Aynı zamanda, “Lider-Üye Etkileşimi” yaklaşımı kalite düzeyi ile “Örgütsel Özdeşleşme Algısı” arasındaki ilişkilerin istatistiksel anlamlılığının olduğu ve pozitif yönlü etkisi tespit edilmiştir. Ayrıca, bağımsız değişken “Lider-Üye Etkileşimi” ile bağımlı değişken “Örgütsel Özdeşleşme Algısı” değişkenleri arasındaki ilişkilerde “Algılanan Örgütsel Destek” değişkeninin bütünleyici kısmi aracılık rolünün olduğu ispatlanmıştır. Tartışma-Araştırma değişkenleri arasındaki teorik ilişkilerin tam da Sosyal Değişim Kuramın anlattığı anlamda şekillendiği görülmektedir. Ayrıca, örgütler ve liderlerle iletişim ve örgütün maddi-manevi katkıları kapsamında çalışanların değiş tokuş temelli etkileşimin, kurumlarıyla bütünleşmelerini artırdığına dair kanıtlara ulaşılmıştır. Bu nedenle, kurumun katkılarının arttığını hisseden çalışanlar; sadece artan bir çaba ile karşılık vermekle kalmayacaklar, aynı zamanda kurumlarıyla da bütünleşecektir.
Forensic Medical Evaluation of Non-Fatal Traumatic Head Bone Fractures
Authors: Şimşek Ümit , Saka Bahadır , Kılıboz Tuğrul , Polat Neslihan , Köse Ömer Seyda , Karbeyaz Kenan
Published: October 2024

Head bone fractures are encountered in forensic medicine practice due to their origin. In the present study, we aimed to evaluate the demographic data, injury characteristics, clinical findings accompanying bone fractures and forensic reports of cases with skull fractures and to share them with the literature. In this study, cases with non-fatal traumatic skull fractures that did not result in death admitted to our department during the 10-year period between 01.01.2014 and 31.12.2023 were included in the study. Hospital documents and investigation documents of the cases were retrospectively analyzed. It was determined that 75.6% of the cases were male and the mean age was 37±9.6 years. It was determined that 56.2% of the skull fractures occurred as a result of traffic accidents, the most common fracture was the frontal bone (n=206, 53.4%) and 54.1% of the cases were linear fractures. In our study, it was determined that skull fractures were most common in males, in the young adult age group, most commonly due to traffic accidents, and in the form of linear fractures in the frontal bone. The findings were consistent with the literature. When preparing a forensic report on skull fractures, the location of the fracture, the type of fracture and the number of fractures are important in terms of determining the life threat and the effect of the fracture on life functions.
AN OVERVIEW OF INVESTIGATING THE NEW STRUCTURAL SYSTEAM(LSF) = UNA RESUMEN DE LA INVESTIGACIÓN DEL NUEVO SISTEMA ESTRUCTURAL (LSF)
Authors: Javaherikhah Amirhossein , Khezli Samane , Valiente-López Mercedes
Published: October 2024

La construcción de estructuras ligeras de acero (LSF) es uno de los métodos constructivos más eficientes actualmente en uso. Debido a la rápida velocidad de este sistema, la calidad superior de la construcción y la adecuada resistencia a los terremotos desde la década de 1950, ahora incluye países como Japón, Estados Unidos y Canadá. Las secciones de acero con paredes delgadas son el componente principal de las estructuras de acero ligeras (LSF). Debido a las características de los perfiles utilizados en este sistema, como la laminación en frío del acero y la ausencia de tensiones residuales en los perfiles, la capacidad de crear perfiles con diversas formas y con alta resistencia y dureza, y precisión y rapidez en la ejecución e instalación de la estructura en comparación con los métodos convencionales. En comparación con los edificios convencionales, la construcción se ejecutó e instaló con mayor precisión y rapidez, al menor costo posible. El empleo de este enfoque de construcción es un método industrial alternativo en proyectos de construcción, así como en viviendas masivas, para disminuir y prevenir el desperdicio de recursos y materiales típicamente presentes en las construcciones tradicionales. En general, el uso de esta estructura es apropiado en todos los sentidos y se ha logrado el objetivo de desarrollo urbano sostenible.AbstractThe construction of light steel structures (LSF) is one of the most efficient construction methods currently in use. Due to this system's fast speed, superior building quality, and adequate earthquake resilience since the 1950s, it now includes countries like Japan, America, and Canada. Steel sections with thin walls are the primary component of light steel structures (LSF). Due to the features of the sections used in this system, such as cold rolling of the steel and the absence of residual stresses in the sections. The ability to create sections with various shapes and with high resistance and hardness, and accuracy and speed in the execution and installation of the structure compared to conventional methods. Compared to typical buildings, the construction was executed and installed with greater precision and speed, at the lowest possible cost. The employment of this construction approach is an alternative industrial method in construction projects as well as mass housing to lessen and prevent the waste of resources and materials typically present in traditional building. this structure's use is appropriate in every way, and the goal of sustainable urban development has been accomplished.
ROBUST STATISTICAL TECHNIQUES FOR EDUCATIONAL EVALUATION IN UNIVERSITY TECHNICAL STUDIES: MEDIAN AND WILCOXON-MANN-WHITNEY (WMW) TEST = TÉCNICAS ESTADÍSTICAS ROBUSTAS PARA LA EVALUACIÓN EDUCATIVA EN ESTUDIOS TÉCNICOS UNIVERSITARIOS: TESTS DE LA MEDIANA Y DE WILCOXON-MANN-WHITNEY (WMW)
Authors: Montes-Pajuelo Raúl , Rodríguez-Pérez Ángel Mariano , Caparros-Mancera Julio José , Rodríguez-González Cesar Antonio
Published: October 2024

El aprendizaje basado en problemas (ABP) es un método de enseñanza que se utiliza cada vez más en la enseñanza técnica. Tanto en la enseñanza de la ingeniería como en la de la arquitectura, el ABP se ha evaluado y ha demostrado su eficacia para mejorar el rendimiento académico de los estudiantes. La necesidad de trabajar en grupo y la limitación del número de alumnos por sesión de ABP requieren el uso de técnicas estadísticas robustas en la evaluación estadística correspondiente. En el presente trabajo se aplicaron dos pruebas estadísticas robustas: la prueba de la mediana y la prueba de Wilcoxon-Mann-Whitney (WMW). Utilizando una muestra de 35 estudiantes del Máster en Ingeniería Industrial de la Universidad de Huelva, distribuidos en tres cursos académicos (2021-22, 2022-23 y 2023-24), se aplicaron dichas pruebas en relación con el rendimiento académico. Hubo un grupo experimental (19 alumnos) y un grupo control (16 alumnos). Se han aclarado los detalles de la aplicación de cada prueba, incluyendo las hipótesis nula y alternativa, los estadísticos respectivos de cada prueba, y se ha resuelto el caso utilizando R. Se demuestra que existe una diferencia significativa en el aprendizaje entre el grupo experimental y el grupo de control, basándose en las pruebas de la mediana y de Wilcoxon-Mann-Whitney (WMW).Problem Based Learning (PBL) is a teaching method that is increasingly being used in technical education. In both engineering and architecture education, PBL has been evaluated and shown to be effective in improving students' academic performance. The need to work in groups and the limitation of the number of students per PBL session require the use of robust statistical techniques in the corresponding statistical evaluation. In the present work, two robust statistical tests were applied: the median test and the Wilcoxon-Mann-Whitney (WMW) test. Using a sample of 35 students of the Master in Industrial Engineering at the University of Huelva, distributed over three academic years (2021-22, 2022-23 and 2023-24), the said tests were applied in relation to academic performance. There was an experimental group (19 students) and a control group (16 students). The details of the application of each test have been clarified, including the null and alternative hypotheses, the respective statistics of each test, and the case has been solved using R. It is shown that there is a significant difference in learning between the experimental group and the control group, based on median and Wilcoxon-Mann-Whitney (WMW) tests.
Legislative Analysis of Spanish Education: from Content-Based Education to Transversal Competency-Based Education = Análisis Legislativo de la Educación Española: de una Educación Basada en Contenidos a la Educación Basada en Competencias Transversales
Authors: Sánchez-Bolívar Lionel , Escalante-González Sergio , Arenas-Carranza Sara , Vázquez Lindsay Michelle
Published: October 2024

La legislación es el eje vertebrador de la política educativa. En función de lo que estipule la normativa educativa se aplicarán unos principios u otros. Este trabajo de investigación emplea un diseño cualitativo, basado en el análisis de contenido de la normativa vigente en España, en materia educativa. Para ello se han seleccionado todas las leyes orgánicas, ordinarias, decretos legislativos, decretos-ley y órdenes ministeriales que afecten total o parcialmente al sistema educativo español. Los principales hallazgos de esta investigación ponen de relieve, por un lado, que el sistema de evaluación educativa ha evolucionado de una evaluación centrada en los conocimientos teóricos a una evaluación centrada en las competencias que el alumnado ha de adquirir en cada etapa educativa; y, por otro lado, que existe una excesiva producción normativa en el campo educativo español, lo que provoca alteraciones en los diferentes subsistemas que conforman el sistema educativoAbstractLegislation is the backbone of education policy. Depending on what the educational regulations stipulate, certain principles will be applied. This research work uses a qualitative design, based on a content analysis of the current legislation in force in Spain in the field of education. For this purpose, all the organic and ordinary laws, legislative decrees, decree-laws and ministerial orders that totally or partially affect the Spanish education system have been selected. The main findings of this research highlight, on the one hand, that the educational assessment system has evolved from an assessment centred on theoretical knowledge to an assessment centred on the competences that students must acquire at each educational stage; and, on the other hand, that there is an excessive production of regulations in the Spanish educational field, which causes alterations in the different subsystems that make up the educational system
MODEL AQUAROBIC UNTUK LANJUT USIA (LANSIA) BERBASIS PERMAINAN
Authors: Fajriah Duha Yusmaini  , Siregar Nofi Marlina
Published: October 2024

Penelitian ini bertujuan untuk membuat model aquarobic untuk lanjut usia (lansia), yaitu di klub olahraga Indonesia Aquarobic Club . Waktu penelitian selama Agustus 2019 – Juli 2020. Metode penelitian ini menggunakan metode penelitian ADDIE, dimana penelitian menggunakan 5 tahapan yaitu Analisis, desain, pengembangan model, pelaksanaan, evaluasi. Hasil penelitian menghasilkan produk yang berupa model aquarobic untuk lanjut usia (lansia) berbasis permainan. yang telah di revisi oleh ahli permainan dan ahli renang sebanyak 10 model yang di implementasikan sebanyak 20 orang Berdasarkan hasil penelitian menunjukkan bahwa model aquarobic untuk lanjut usia (lansia) berbasis permainan ini dapat menjadi media untuk digunakan dalam proses latihan aquarobic untuk lansia, sehingga dapat memberikan kontribusi yang baik terhadap pelatih dan para lansia, berdasarkan hasil penelitian model aquarobic untuk lanjut usia (lansia) berbasis permainan dapat dikembangkan dan dapat diterapkan kepada klub olahraga Indonesia Aquarobic Club dan klub olahraga aquarobic lainnya.
Strategi Pengembangan Olahraga Rekreasi Freestyle Soccer di KORMI DKI Jakarta
Authors: Ardiansyah Arie , Arif Muhamad , Fitranto Nur
Published: October 2024

,  Penelitian ini merupakan penelitian deskriptif, dengan metode penelitian deskriptif kualitatif dengan menggunakan prosedur pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi. yang digunakan menggunakan trianggulasi data, sumber, teknik dan waktu. Untuk mendapatkan hasil penelitian yang sesuai penulis melakukan wawancara dengan beberapa informan yakni Saudara Jerry Anggoro, S.S selaku ketua IF3 DKI Jakarta, Raihan Madani selaku Atlet freestyle soccer dan juga Drs.H. Muhammad Sarkawi selaku ketua KORMI (Komite Olahraga Rekreasi dan Masyarakat Indonesia) Penelitian ini bertujuan untuk mengambangkan strategi pengembangan olahraga rekreasi freestyle soccer pada KORMI DKI Jakarta sehingga olahraga rekreasi freestyle soccer dapat berkembang dan semakin meluas dikalangan masyarakat. Freestyle soccer merupakan bagian dari seni memainkan bola yang dilakukan dengan sebuah gaya dan trik yang memilik unsur keindahan dan unsur rekreasi untuk memainkan olahrga ini. Hasil penelitian menunjukkan bahwa organisasi IF3 DKI Jakarta Belum bersinergi dengan baik bersama KORMI DKI Jakarta Sehingga tidak berjalannya sistem organisasi yang mengakibatkan tidak berkembang nya olahraga rekreasi freestyle soccer di DKI Jakarta. Setelah melakukan observasi peneltian ini yang harus dilakukan adalah membenahi sistem yang ada di organisasi dan memperbaiki kekurangan organisasi dengan adanya observasi ini agar tujuan di dalamnya dapat tercapai sehingga olahraga rekreasi freestyle soccer dapat berkembang.
Model Physical Activity Berbasis Permainan Pada Disabilitas Netra
Authors: Fatimatuz Zahra Andi , Fajar Vidya Hartono  , Abdul Kholik
Published: October 2024

Kegiatan aktivitas fisik disabilitas netra dengan membuat suatu program permainan modifikasi. Program ini dibuat dalam bentuk rekreasi terdapat unsur permainan di dalam nya. Tujuan dari dibuatnya permainan ialah untuk membuat kegiatan yang selama ini dianggap membosankan menjadi lebih bervariatif dan menarik, sehingga para disabilitas netra bisa melakukan kegiatan dengan senang bahkan berpotensi membuat mereka menjadi lebih aktif bergerak serta rajin melakukan aktivitas. Menurut Dick et al. (2005) mengembangkan model-model pengembangan yaitu model ADDIE, model tersebut terdiri dari lima tahapan pengembangan. Model yang melibatkan tahap-tahap pengembangan model dengan lima langkah atau fase pengembangan meliputi: Analysis, Design, Development or Production, Implementation or Delivery and Evaluations. Melihat hasil dari penelitian Model Physical Activity Berbasis Permainan Pada Disabilitas Netra dapat memberikan kontribusi yang baik bagi anak-anak disaat tidak ada kegiatan di Panti Sosial Bina Netra dan Rungu Wicara Cahaya Batin, memberikan kontribusi yang baik juga kepada pengelola Panti Sosial Bina Netra dan Rungu Wicara Cahaya Batin dalam proses penelitian ini. Sehubung dengan produk yang di buat yaitu Model Physical Activity Berbasis Permainan Pada Disabilitas Netra, hal ini anak-anak sangatlah antusias dalam melakukan aktivitas fisik berbasis permainan, peneliti akan memberikan saran yang meliputi.
Peran Media Sosial Instagram Dalam Pengembangan Objek Wisata Nara Kupu Village Depok
Authors: Pascal Juan , Aan Wasan  , Masnur Ali
Published: October 2024

Abstrak. Objek wisata Nara Kupu Village Depok merupakan salah satu objek wisata yang berada di Citayam, Depok, dengan memiliki konsep sebagai Hidden Gem yang digunakan sebagai tempat agro-eduwisata dengan 3 anak bisnis yaitu Kedai Kebun Nara Kopi, Sayur Kendal, Klinik KJP Nara, serta memiliki daya tarik spesies Rusa sebagai Icon dari objek wisata tersebut. Penelitian ini bertujuan untuk mengetahui sejauh mana peran media sosial Instagram yang digunakan baik pengelola maupun pengunjung objek wisata Nara Kupu Village Depok terhadap pengembangan objek wisata itu sendiri. Penelitian ini dilakukan di Jl. Garuda 4, RT.1/RW.5, Pasir Putih, Kec.Sawangan, Kota Depok, Jawa Barat 16519 pada 28 Juni 2023 sampai dengan 4 Juli 2023. Metode yang digunakan dalam penelitian ini adalah metode Deskriptif Kualitatif. Subjek penelitian dalam penelitian ini adalah sumber daya manusia yang ada ada di dalam kepengurusan Nara Kupu Village Depok yaitu pengelola utama, pengelola Kedai Kebun Nara Kopi dan pengelola PIC Tamu. Pengunjung diambil secara Random Sampling dengan 5 sampai 7 orang. Teknik pengumpulan data menggunakan triangulasi data dengan pedoman hasil observasi, wawancara dan dokumentasi. Temuan Penelitian ini bertujuan untuk melihat tingkat efektifitas media sosial Instagram dari pengelola maupun pengunjung. Selain itu, penelitian ini dapat diketahui secara lengkap mengenai kelebihan tentang konsep edukasi agro-eduwisata, sedangkan kekurangannya yaitu mengenai akses transportasi, sumber daya manusia yang kurang, faktor eksternal seperti curah hujan tingkat tinggi serta media sosial yang dikelola oleh pengelola dan Tim Nara Kupu yang masih kurang spesifik.
Full-scale evaluation of saltwater concrete for airfield pavement construction and repair
Authors: Tibbetts Caitlin , Doyle Jesse , Robinson W. , Tseng Ester , Bonelli Joseph , Turner Robert
Published: October 2024

The US Navy has a need to rapidly construct concrete facilities onshore to support contingency operations. Mixing water for concrete is typically specified to be freshwater; however, in many scenarios there are limited amounts of freshwater available for construction. Thus, use of readily available saltwater would be advantageous. This project’s objective was to evaluate the suitability of saltwater as a replacement for freshwater for producing concrete airfield pavement under relevant operational scenarios. Three full-scale test sections were constructed, and performance was evaluated in the context of relatively short design life requirements. First, direct comparison slabs of freshwater and saltwater concrete were constructed and exposed to ambient environmental conditions for one year; periodic concrete strength measurements were made. Next, 8 in. thick and 11 in. thick saltwater concrete pavements were constructed then subjected to P-8 aircraft accelerated loading. Finally, four airfield damage repair techniques were executed using saltwater and subjected to accelerated P-8 aircraft loading. Saltwater concrete performance was found to be similar to freshwater concrete for all scenarios investigated. The overall conclusion was that saltwater can be used in place of freshwater for concrete airfield pavement construction and repair for short- to medium-term use (1–2 yr) with no meaningful impact to mission requirements.
Rationale and protocol of the LEAD 2.0 study: A randomized controlled trial assessing the feasibility of a virtually-delivered 6-month exercise and nutrition intervention in older adults with subjective cognitive decline (SCD)
Authors: Neudorf Bobby , Koblinsky Noah , Power Krista , Binns Malcom , Fiocco Alexandra J. , Rotenberg Shlomit , Marzolini Susan , Oh Paul , Thornton Jane , Ajwani Fatim , Sullivan Kylie , Chevalier Stéphanie , Russell Caryl , Ferland Guylaine , Anderson Nicole D. , Middleton Laura E.
Published: October 2024

Background
With growing prevalence of dementia worldwide, dementia risk reduction is a key interest of the World Health Organization’s Global Dementia Action Plan. Subjective cognitive decline (SCD) is a prominent predictor of future dementia diagnosis. Therefore, people with SCD are an important group for dementia prevention intervention. Exercise and healthy diet are associated with a 30–60% decrease in dementia risk in longitudinal studies. Technological advances yield the potential of trials that deliver lifestyle interventions virtually, reaching people in a wide geographical spread. However, the feasibility of large-scale virtual trials still needs to be established.
Objective
This trial aims to examine the feasibility of a factorial randomized controlled trial exploring a 6-month virtual, exercise and healthy diet intervention.
Methods
We will recruit 140 older adults (65 + years) with SCD, who will receive a combination of: Aerobic and Resistance Exercise (EX) or Stretching and Toning (STRETCH) and either Diet Counselling (DIET) or Brain Health Education (ED);. Participants will be randomized to four weekly hours of one of four intervention arms: (1) EX and DIET; 2) EX and ED; 3) STRETCH and DIET; or 4) STRETCH and ED. EX will include moderate intensity aerobic and resistance training. DIET will instruct participants in brain healthy food choices. Assessments will be performed virtually at baseline, 6 months (post-intervention), and 12 months. Feasibility will be measured by recruitment rate, adherence, and retention.
Discussion
Established feasibility will set the stage for a definitive trial. Feasibility results will also inform future virtual programs/services. In the long-term, if the interventions are feasible and beneficial, this intervention model could scale up and spread quickly to reach at-risk individuals for the purpose of dementia risk reduction.
Trial registration:
The Lifestyle, Exercise, and Diet (LEAD 2.0) study is registered with the US National Institutes of Health clinical trials registry (ClinicalTrial.gov identifier NCT06078748). This report complies with the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement.
The NMDA receptor subunit GluN2D is a target for rapid antidepressant action
Authors: Normann Claus , Vestring Stefan , Veleanu Maxime , Perez Marina Conde , Bronnec Martin , Li Anna , Würz Lovis , Erdogdu Fatih , Stocker Julia , Moos Johanna , Weigel David , Theiß Alice , Wendler Elisabeth , Borger Lotta , Voita Sabine , Heynicke Franziska , Brandl Jakob , Hummel Fabian , Vivet Clotilde , Jocher Dorothea , Loewe Pauline , Barmann Simon , Smoltczyk Lea , Zimmermann Stella , Prabhakaran Prejwal , Sarrazin David , Suarez-Marchi Guillermo Jose , Bernhardt Judith , Lokaj Granita , du Vinage Catherine , Grießbach Elisa , Lais Julia , Gensch Nicole , Günther Stefan , Moumbock Aurélien , Domschke Katharina , Serchov Tsvetan , Bischofberger Josef
Published: October 2024

Ketamine is the first glutamatergic agent in clinical use for major depression. The underlying mechanism and primary target of ketamine are unknown; further research is urgently needed to develop more specific interventions with fewer side effects and better treatment outcomes for severely affected patients. Ketamine is a noncompetitive antagonist of the glutamatergic N-methyl-D-aspartate (NMDA) receptor, a heterotetramer composed of two GluN1 and two GluN2 subunits. Here, we show that ketamine preferentially targets GluN2D-containing NMDA receptors on interneurons, and that selective GluN2D antagonism alone is sufficient to produce rapid antidepressant effects. We used ketamine, selective GluN2D inhibitors, GRIN2D-siRNA and chemogenetic approaches in hippocampal brain slices and in vivo in mice. We found that GluN2D antagonism inhibited NMDAR currents in interneurons but not in pyramidal cells. GluN2D-mediated recruitment of GABAergic interneurons powerfully controls feedback and feed-forward inhibitory circuits to moderate hippocampal network activity and synaptic plasticity. In a mouse model of depression, GluN2D inhibition recovered synaptic excitation-inhibition balance, reversed long-term potentiation deficits and restored synaptic and AMPAR density toward a naïve state. GluN2D antagonism could fully mimic the cellular and behavioral antidepressant actions of ketamine with fewer side effects in terms of motor coordination and anxiety. These findings identify novel and a highly specific target for drug treatment of major depression.
Cross-Cultural Adaptation and Psychometric Properties of Version 8 of the Montreal Cognitive Assessment (MOCA) In Detecting Mild Cognitive Impairment and Dementia among Older People in Tanzania, A Methodological study/Diagnostic accuracy comparative study
Authors: Nyika Recton G , Masika Golden M
Published: October 2024

Background
The early detection of cognitive deficits in older individuals in Tanzania, particularly those in urban areas with higher levels of education, requires the use of standardized and internationally recognized assessment tools. MoCA version 8, which assesses eight cognitive domains, has been modified to enhance scoring precision and includes instructions on calculating the memory index score (MIS). Additionally, the verbal fluency and abstraction tasks have been revised to facilitate the design of targeted interventions. This study aims to culturally adapt MoCA 8 into Swahili and evaluate its validity, reliability, and diagnostic accuracy for assessing cognitive function in older Tanzanians.
Method/design
In this methodological study, 240 older individuals (aged ≥50 years) will be recruited from ten randomly chosen villages in both rural and urban areas of the Dodoma region. The MoCA version 8 will serve as the primary screening test, while the MoCA-5minutes protocol will be used as the reference standard screening test. The diagnostic accuracy (power) of the MoCA version 8 will be assessed by comparing its scores with the diagnosis made by a Neurologist using DSM-5 criteria. Data collection will commence after obtaining informed consent to confirm participants' eligibility for the study. The main areas of interest include the Swahili version, validity, reliability, and diagnostic accuracy of MoCA version 8.
The Validity, Reliability, Sensitivity, Specificity, Predictive (positive and negative) values will also be reported.
Discussion
The results of this study will determine whether MoCA 8 is a valid, reliable and accurate screening tool in detecting cognitive function of older people in Tanzania, this will serve as a study to inform the literature and to indicate the manner in which early detection of cognitive impairment will inform early intervention to improve cognitive function.
Comparison of outcomes of gamma knife radiosurgery for secondary and de novo grade 2 meningiomas: a single-center retrospective study
Authors: Song Dili , Hu Guangxin , Shen Liping , Yu Jinxiu , Fu Jiaming , Wang Zijing , Chen Lin , Liu Xinwu , Zhou Xiaomin , Cai Yongguang , Fu Junyi
Published: October 2024

Objective
The purpose of this study was to compare outcomes between secondary and de novo grade 2 meningiomas undergoing Gamma Knife radiosurgery (GKRS).
Methods
Eighteen patients, including secondary grade 2 meningioma group (n = 6) and de novo grade 2 meningioma group (n = 12), treated with GKRS were enrolled in this single-center retrospective study.
Results
The median tumor volume was 23.4 (range, 5.5–104.0) ml and 9.4 (range, 0.4–24.9) ml in secondary and de novo grade 2 meningioma group respectively (p = 0.061). Ten patients (55.6%) experienced radiological progression with a median follow-up time of 35.7 (range, 9.4-138.2) months. The median time to radiological progression was 34.5 (range, 14.5–97.7) months. The radiological progression-free survival (PFS) was 74%, 55%, and 15% at 2, 3 and 5 years respectively. The radiological PFS at 2 and 3 years was 60% and 20%, 82% and 82% in secondary and de novo grade 2 group respectively. Secondary grade 2 meningiomas were significantly related with poorer radiological PFS in univariate analysis (p = 0.021). Nine patients (50%) occurred clinical progression in the study, including headache (n = 7), cranial nerve dysfunction (n = 5), seizure (n = 1) and extremity weakness (n = 1). Secondary grade 2 meningiomas were significantly related with clinical progression in univariate analysis (p = 0.045).
Conclusions
Secondary grade 2 meningiomas had a shorter radiological and clinical PFS after GKRS than de novo grade 2 meningiomas. Secondary grade 2 meningiomas were an independent risk factor for poor prognosis after GKRS.
Effects of transcranial photobiomodulation on peripheral biomarkers associated with oxidative stress and complex IV activity in the prefrontal cortex in rats subjected to chronic mild stress
Authors: Bortoluzzi Luciana , Colombo Rafael , Pinto Karoline Borges Motta , Viscardi Lucas Henriques , Missiaggia Ricardo , Turella Douglas Jean , Schwantess Lisandra , Salvador Mirian , Branco Catia Santos , Rigotti Marina , Scotton Ellen , Schons Tainá , Ribeiro Silene Bazi , Caldieraro Marco Antonio , Rosa Adriane Ribeiro
Published: October 2024

This study addresses the need for effective alternatives to treat major depressive disorder (MDD) in patients who do not respond to conventional therapies. Transcranial photobiomodulation therapy (tPBM) shows promise by enhancing mitochondrial function and reducing oxidative stress, as demonstrated in the chronic mild stress (CMS) rat model. This study aimed to analyze the impact of tPBM with two wavelengths (red and infrared) on behavioral and biological parameters related to MDD in a CMS model. Male rats were subjected to CMS for five weeks and categorized into resilient and susceptible groups using the sucrose consumption test. The CMS-S group received tPBM treatment (600nm and 840nm) for five weeks. Biological measures included lipid damage (TBARS), antioxidant defense (TEAC), mitochondrial complex IV activity (CCO), and nitric oxide (NO) concentration in the prefrontal cortex and blood. Post-tPBM treatment (both red and infrared groups) exhibited increased sucrose consumption compared to the sham (Kruskal-Wallis chi-squared=26.131; p<0.001). Both groups presented higher serum TEAC levels than the sham and control groups, although these effects were not statistically significant (p=0.306). The red group showed lower peripheral TBARS levels (M=9.50, SD=2.87) than the sham group (M=13.66, SD=2.20, p=0.0048). The infrared group showed higher NO levels in the hippocampus than the sham group (Mean=107.83, SD=6.48, Dunn-Test p=0.0134) and higher prefrontal CCO activity levels than the red group (p=0.012). This study demonstrated that tPBM using both wavelengths significantly improved behavioral and biological parameters in the CMS rat model, suggesting potential therapeutic benefits for MDD by ameliorating oxidative stress and enhancing mitochondrial function.
Impact of Stem Collar-Calcar Gap Distance on Postoperative Bone Remodeling in Fully Hydroxyapatite-coated Stem
Authors: Ohashi Yoshihisa , Fukushima Kensuke , Osaki Yuto , Tsuchiya Maho , Saito Hiroki , Uchida Kentaro , Uchiyama Katsufumi , Takahira Naonobu , Takaso Masashi
Published: October 2024

The collar of a cementless stem in total hip arthroplasty (THA) improves fixation and stability by connecting with the femoral calcar. Proper attachment is essential for reducing micromotion and preventing periprosthetic fractures of the femur. However, gaps between the femoral calcar and stem collar can occur during surgery, and it is unclear what degree of gap can be tolerated. This study evaluated 156 patients who received primary THA with the CORAIL stem. Medial and lateral gap distance were measured by frontal X-ray of the hip joint at 1 week and 1, 3, 6, 12, 24, and 36 months after THA. Clinical outcomes were assessed using Japanese Orthopaedic Association hip scores, and radiographic assessments included femoral morphology and stem alignment. Gaps were initially observed in 55 patients, with 42 showing complete gap disappearance within 36 months. On logistic regression analysis, lateral gap distance was shown to significantly influence gap disappearance, with an optimal cut-off of 5.5 mm by receiver operating characteristic curve analysis. A smaller lateral gap was correlated with quicker closure. When the gap between the collar and femoral calcar is within 5.5 mm, gap disappearance can be expected due to postoperative bone remodeling.
Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study
Authors: OHSETO Hisashi , ISHIKURO Mami , OBARA Taku , NARITA Akira , TAKAHASHI Ippei , SHINODA Genki , NODA Aoi , MURAKAMI Keiko , ORUI Masatsugu , IWAMA Noriyuki , KIKUYA Masahiro , METOKI Hirohito , SUGAWARA Junichi , TAMIYA Gen , KURIYAMA Shinichi
Published: October 2024

Genomic information from pregnant women and the paternal parent of their fetuses may provide effective biomarkers for preeclampsia (PE). This study investigated the association of parental polygenic risk scores (PRSs) for blood pressure (BP) and PE with PE onset and evaluated predictive performances of PRSs using clinical predictive variables. In the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, 19,836 participants were genotyped using either Affymetrix Axiom Japonica Array v2 (further divided into two cohorts—the PRS training cohort and the internal-validation cohort—at a ratio of 1:2) or Japonica Array NEO (external-validation cohort). PRSs were calculated for systolic BP (SBP), diastolic BP (DBP), and PE and hyperparameters for PRS calculation were optimized in the training cohort. PE onset was markedly associated with maternal SBP-, DBP-, and PE-PRSs in internal- and external-validation cohorts and with paternal SBP- and DBP-PRSs only in the external-validation cohort. Maternal DBP-PRS calculated using “LDpred2” presented the most improvement in prediction models and provided additional predictive information on clinical predictive variables. Paternal DBP-PRS improved prediction models in the internal-validation cohort. In conclusion, Parental PRS, along with clinical predictive variables, is potentially useful for predicting PE.
Prognosis and outcome of renal tuberculosis after nephrectomy
Authors: Wang Shun , Tian Yuan , Wang Qing , Jiang Kehua , Sun Fa , Li Tao
Published: October 2024

Background
Researches has proved that nephrectomy combine with anti-tuberculosis therapy were effective methods for renal tuberculosis, but whether it could also reduce the complications after one year later or longer has never been reported.
Methods
The clinical data, anti-tuberculosis strategy and the occurrence and management of renal tuberculosis related long-term complications (including bladder contracture, contralateral hydronephrosis, lower urinary tract symptoms [LUTS] and tuberculosis recurrence) were reviewed and analyzed. Meanwhile, the logistic regression analysis was used to explore the impactors of long-term complications.
Results
A total of 146 patients were successfully followed up. Among them, 3 cases developed bladder contracture after nephrectomy whose life quality was significantly improved after bladder augmentation. 9 patients showed contralateral hydronephrosis, with four cases were diagnosed preoperatively and five postoperatively. The preoperative symptoms of tuberculosis toxicity significantly increased the incidence of postoperative contralateral hydronephrosis. 17 patients suffered from severe LUTS, with 11 individuals occurred preoperatively and six developed postoperatively, and the elevated preoperative white blood cell counts and globulin level significantly influenced the new-onset LUTS risk. 2 patients experienced postoperative recurrence of pulmonary tuberculosis and cured by another regular anti tuberculosis treatment. 12 patients experienced postoperative flank pain, of which 7 cases were new-onset and five were pre-existing. The older age increased the risk of postoperative flank pain.
Conclusion
Preoperative symptoms of tuberculosis toxicity significantly increased the risk of the postoperative renal hydronephrosis, while elevated white blood cell counts and reduced globulin levels before surgery increased the risk of new-onset postoperative LUTS, and the older the patient, the higher the risk of postoperative flank pain.
Effect of lifestyle intervention on mobilization of fat storage pools in individuals with abdominal obesity: a prospective study
Authors: Liu Hong , Duan Junhong , Liu Yichen , Guan Gaopeng , Liu Jie , Liu Min , Jin Ping , Rong Pengfei
Published: October 2024

Objective
The effect of lifestyle intervention on the reduction of fat in specific body areas for individuals with abdominal obesity has not been thoroughly studied. In this study, we evaluate if lifestyle intervention can uniquely influence various fat storage areas and to explore the relationships between fat loss in specific locations and health results.
Methods
In this prospective cohort study conducted at a single center, 39 individuals with abdominal obesity participated in a lifestyle intervention from October 18, 2022, to April 20, 2023. Magnetic resonance imaging was used to measure subcutaneous fat area (SFA), visceral fat area (VFA), and the proton density fat fraction (PDFF) of the liver and pancreas at the baseline and six months post-intervention. This study's protocol was documented on clinicaltrials.gov.
Results
Out of 39 individuals, the median age was 28.0 years with an interquartile range (IQR) of 22.0 to 37.5 years. The median body mass index (BMI) was 30.4 kg/m2, with an IQR of 28.5 to 33.2 kg/m2, and 41.0% of the participants were female. The median (IQR) reduction in hepatic PDFF was highest after lifestyle intervention at 46.5% (28.8%-68.4%), followed by pancreatic PDFF reduction at 24.9% (10.4%-45.0%), VFA reduction at 19.5% (7.2%-32.3%), and SFA reduction at 12.2% (6.7%-18.9%) (P < 0.001). Using the Pearson correlation coefficient, positive relationships were identified between variations in VFA and alterations in fasting glucose and HOMA-IR (r = 0.401, P = 0.01; r = 0.830, P < 0.001), as well as between changes in hepatic PDFF and HOMA-IR (r = 0.520, P < 0.001).
Conclusion
Lifestyle intervention primarily reduced liver fat, then pancreatic fat and visceral fat, while subcutaneous fat was the least affected in individuals with abdominal obesity. Decreases in VAT and liver fat are independently linked to the improvement of glucose metabolism following lifestyle intervention.