bluuebunny/crossref_metadata_2025 huggingface dataset:
Conversor CA-CC de Estágio Integrado Cascateado para Aplicações em Transformadores de Estado Sólido
Authors: Praça Paulo P. , Araújo José W. M. de , Honório Dalton A. , Oliveira Demercil S. , Barreto Luiz Henrique S. C.
Published: December 2019

Este artigo propõe o estudo e desenvolvimento de um conversor CA-CC multinível de estágio integrado para aplicação em transformadores de estado sólido. A topologia proposta é baseada no conversor dual active bridge (DAB) associado com a célula de comutação de três estados (CC3E). O conversor possui uma estrutura que pode ser modularizada e aplicada em elevadas tensões podendo operar tanto como retificador quanto inversor. Buscando validar todo o estudo feito, foi montado um protótipo com dois módulos de 1 kW cada, com tensão CA de entrada de 110 Vrms, tensão no barramento primário e secundário de 400 V e frequência de chaveamento de 20 kHz. Os resultados experimentais mostram de forma clara e consistente a correta operação do conversor. A bidirecionalidade da estrutura é demonstrada com ensaios de inversão de fluxo. A topologia é capaz de operar com alto fator de potência e baixa DHT (Distorsão Harmônica Total).
AS MULHERES NO PROGRAMA DE AQUISIÇÃO DE ALIMENTOS (PAA) NOS MUNICÍPIOS DE MIRANTE DO PARANAPANEMA E ROSANA (SP)
Authors: Silva Eliane Regina Francisco da , Hespanhol Rosangela Aparecida de Medeiros
Published: December 2019

THE WOMEN IN THE PROGRAM OF FOOD ACQUISITION (PAA) IN THE MUNICIPALITIES OF MIRANTE DO PARANAPANEMA AND ROSANA (SP)LAS MUJERES EN EL PROGRAMA DE ADQUISICIÓN DE ALIMENTOS (PAA) EN LOS MUNICIPIOS DE MIRANTE DEL PARANAPANEMA Y ROSANA (SP)RESUMOO objetivo deste artigo é analisar a participação das mulheres no Programa de Aquisição de Alimentos (PAA) nos municípios de Mirante do Paranapanema e Rosana (SP). Buscamos expor algumas características dos municípios em questão e, em especial, de que forma o programa tem contribuído para a conquista da autonomia das agricultoras familiares. Os procedimentos metodológicos utilizados foram a pesquisa de campo durante os meses de março e abril de 2016 nos municípios selecionados e o levantamento bibliográfico. Os resultados obtidos mostraram que o PAA tem contribuído para a autonomia socioeconômica das mulheres e para a valorização e visibilidade do trabalho destas na escala nacional.Palavras-chave: PAA; Mulheres na Agricultura; Municípios de Mirante do Paranapanema e Rosana (SP).ABSTRACTThe objective of this article is to analyze the participation of women in the Food Acquisition Program (PAA) in the municipalities of Mirante do Paranapanema and Rosana (SP). We seek to outline some characteristics of the municipalities in question and, in particular, how the program has contributed to the achievement of the autonomy of family farmers. The methodological procedures used were the field research during the months of March and April of 2016 in the selected municipalities and the bibliographic survey. The results showed that the PAA has contributed to the socioeconomic autonomy of women and to the valorization and visibility of their work.Keywords: PAA; Women in Agriculture; Municipalities of Mirante do Paranapanema and Rosana (SP).RESUMENEl objetivo de este artículo es analizar la participación de las mujeres en el Programa de Adquisición de Alimentos (PAA) en los municipios de Mirante do Paranapanema y Rosana (SP). Buscamos exponer algunas características de los municipios en cuestión y, en especial de qué forma el programa ha contribuido a la conquista de la autonomía de las agricultoras familiares. Los procedimientos metodológicos utilizados fueron la investigación de campo durante los meses de marzo y abril de 2016 en los municipios seleccionados y el levantamiento bibliográfico. Los resultados obtenidos mostraron que el PAA ha contribuido a la autonomía socioeconómica de las mujeres ya la valorización y visibilidad del trabajo de éstas.Palabras clave: PAA; Mujeres en la Agricultura; Municipios de Mirante do Paranapanema y Rosana (SP).
CAVALCANTE, Sylvia; ELALI, Gleice A. (org.). Psicologia ambiental: conceitos para a leitura da relação pessoa-ambiente. Petrópolis: Vozes, 2018.
Authors: Morais Bárbara Oliveira de , Lopes Alexandre Ferreira
Published: December 2019

Publicado em 2018, o livro “Psicologia ambiental: conceitos para a leitura da relação pessoa-ambiente” é a soma da investigação de professores e pesquisadores associados ao Grupo de Trabalho em Psicologia Ambiental da Associação Nacional de Pesquisa e Pós-Graduação em Psicologia (ANPEPP) e de autores de outros países. Escrito por trinta e duas mãos e organizado em vinte e três capítulos. Um dos diferenciais da obra é que ao longo dos capítulos há a exposição do tema que será tratado, exibido através de um resumo intitulado “Entendimento Geral”. Ao término de cada capítulo há também o convite para visitação dos capítulos que se relacionam ao título lido, servindo, portanto, de leituras complementares ao entendimento da temática abordada.
THE INFLUENCE OF WATCHING NEWS ABOUT CHURCH BOMBINGS IN SURABAYA ON THE PUBLIC PERCEPTION TOWARD THE VEILED MUSLIM WOMEN IN YOGYAKARTA
Authors: Adhiarso Dendy Suseno
Published: December 2019

Wearing veil is the right for Muslim women in Indonesia. However, they should be careful with the recent social condition. Some people feel anxious, fear or even suspicious against veiled Muslim women. Moreover, after both electronic and social media provided information on terrorism cases, most people assume that it is done by Muslims. Based on the negative perception, the study aims to observe the effects of watching news about church bombing in Surabaya to people’s opinion about the veiled Muslim woman in Yogyakarta. The theory in this study is the cultivation and meaning of the message. This research is a quantitative method, precisely using a survey. The data are retrieved using questionnaires, and samples and are taken using purposive sampling technique. The result shows that R. Square is 0.227 which means that 22.7% variable factors’ perception on veiled Muslim women are affected after watching news about church bombing, while the 77.3% is affected by other variables. Based on the ANOVA, the value of F count equals to 28.827 with a 0.000 probability level (significance) which means watching a news about church bombing in Surabaya has significant impact on the public perception of the veiled Muslim women.
LOCAL POLITICAL PARTIES IN ACEH IN 2017 REGIONAL ELECTION: Analysis of Political Identity and Islamization Issue
Authors: Syarif Muhammad Rajiv
Published: December 2019

The existence of local political parties in outline is a new alternative to the implementation of local democratic processes in Aceh are not specifically for Islamization issues. In the political record, the process of electing leaders in Aceh Province has been noted for three times (2006, 2012 and 2017). Aceh continues to move dynamically with political activities that are often rarely predictable or new conflicts that are sometimes expected to occur during democratic parties. This paper examines factors of voter's behavior and political identity in Aceh after the signing peace agreement in 2005 as well as analyzes the regional elections in 2017 and the Islamization issue within it. It will be explained that the behavior of voters in the Aceh regional election is very crucial. The election runs successfully by playing the identity of the political party in the Islamic shari'a area bringing issues in local implementation's policy. Finally, the crisis of trust that has been happening to national political parties has become one of the benchmarks for people to participate in the implementation of local democracy through the emergence of local political parties in Aceh.
ISLAMIC HUMANISM IN INDONESIA'S CONTEXT: Discourse Analysis of Nationality Problems in Indonesia
Authors: Wahyudin Wahyudin , Maimun Agus , Jalil Mat
Published: December 2019

The thought of humanism originated in Athens. As a universal ideology, humanism is the foundation of modern civilization in the western and the eastern world. As an ideology, humanism is adopted by many third world countries, including Indonesia. Although there have been many discussions on Humanism, studies on Humanism in Islam perspective related to tolerance, freedom, and equality in Indonesia’s context have not been carried out. This study attempts to fill that gap including the values of tolerance, freedom, and equality of rights in Indonesia. It is conducted to discover the Islamic humanism developed in Indonesia. The results of the study are: (1) the Islamic humanism is very relevant in Indonesian context which has life philosophy of Pancasila; (2) tolerance as part of Islamic humanism still stands tall in Indonesia because people assume that it has high enthusiasm for safeguarding human dignity; (3) freedom of society in religion, expressing opinion, politics, and other national and state life activities has been guaranteed by the law, although there are still some restrictions by the government on freedom of society; (4) equality rights wise, there are still some Indonesian people who still get unfair law treatment, for example many low-economic level citizens who steal trivial items get severe penalties, while the corruptors stealing bigger amount of money often roam freely without supervision.
Determinan yang Mempengaruhi Financial Performance pada Perusahaan Asuransi Umum Syariah di Indonesia
Authors: Munawaroh Sofiyatul , Mukhibad Hasan
Published: December 2019

The aims of this research are to identify the impact of size, leverage, age, volume of capital growth, tabarru’ funds, independent commissioner ratio, and investment growth on the financial performance in Sharia Non-Life Insurance Company in Indonesia during 2015-2017. The samples obtain 63 units of analysis are selected using purposive sampling method. The data is analysed using descriptive statistical analysis and panel data regressing in E Views 9. Result of this study indicate that size, age, and volume of capital growth have a positively and significantly effect. Investment growth have a negatively and significantly effect. Meanwhile, leverage, tabarru’ fuds and independent commissioner ratio do not have significant effect on the financial performance. Suggestion in this research is the following researchers are expected to extend the duration of the study, so the results of the study become more accurate.[Penelitian ini mempunyai tujuan untuk mengidentifikasi adanya pengaruh size (ukuran perusahaan), leverage (rasio hutang), age (umur perusahaan), pertumbuhan volume of capital, dana tabarru’, rasio komisaris indepeden, dan pertumbuhan investasi pada financial performance perusahaan asuransi umum syariah di Indonesia periode tahun 2015-2017. Metode penentuan sampel dalam penelitian ini yaitu metode purposive sampling dan didapatlan hasil sebanyak 63 unit analisis. Analisis data dalam studi ini yaitu analisis deskriptif dan analisis regresi data panel dengan menggunakan tool E Views 9. Penelitian ini menghasilkan bahwa size (ukuran perusahaan), age (umur perusahaan), dan pertumbuhan volume of capital mempunyai pengaruh positif dan signifikan terhadap financial performance. Sementara itu, pertumbuhan investasi mempunyai pengaruh dengan arah negatif dan signifikan pada financial performance, sedangkan leverage (rasio hutang), dana tabarru’, dan rasio komisaris independen tidak mempengaruhi financial performance. Saran dalam penelitian ini untuk menghasilkan penelitian lebih akurat maka sebaiknya penelitian selanjutnya dilakukan dalam jangka waktu yang lebih panjang.]
Dampak Keberadaan Minimarket terhadap Toko Kelontong di Pasar Klampis Kabupaten Bangkalan Madura
Authors: Muhzinat Zumrotul , Achiria Siti
Published: December 2019

This research was conducted to determine the impact of the presence of minimarkets on grocery stores in the Klampis Market, Bangkalan Madura. The emergence of modern markets such as Indomart and Alfamart can influence people's perceptions of decreasing turnover and the decreasing number of customers. This study uses a qualitative descriptive approach. The research location was conducted at several grocery stores around the Klampis market minimarket, Bangkalan Madura. The technique of determining informants in this study used purposive sampling. Data collection techniques in this study using Field Work Research.This study concluded that the existence of minimarkets caused the sellers of grocery stores to lose their customers and the income received also declined. However, this did not dampen the desire of grocery store traders to be able to compete with minimarkets, namely by providing basic necessities that were not available at the convenience store.[Penelitian ini dilakukan untuk mengetahui dampak keberadaan minimarket terhadap toko kelontong di pasar Klampis Kabupaten Bangkalan Madura. Kemunculan pasar modern seperti Indomart dan Alfamart dapat berpengaruh terhadap persepsi masyarakat tentang menurunnya omset dan jumlah pelanggannya yang semakin berkurang. Penelitian ini menggunakan metode pendekatan deskriptif kualitatif. Lokasi penelitian di lakukan pada beberapa toko kelontong yang ada disekitar minimarket pasar Klampis Kabupaten Bangkalan Madura. Teknik penentuan informan dalam penelitian ini menggunakan purposive sampling. Teknik pengumpulan data dalam penelitian ini menggunakan Field Work Research. Penelitian ini menyimpulkan bahwa keberadaan minimarket menyebabkan para pedagang toko kelontong kehilangan konsumennya serta pendapatan yang diterima juga semakin menurun. Namun hal tersebut tak menyurutkan keinginan para pedagang toko kelontongan untuk dapat bersaing dengan minimarket yaitu dengan menyediakan barang-barang kebutuhan pokok yang tidak tersedia di minimarket.]
Investigation of the Effects of Sun-Dried Apricot with Different Sulfur Levels on Oxidative Stress Markers
Authors: KIRAN Tuğba Raika , OTLU Onder , KARABULUT Ercan , OZCAN Nermin
Published: December 2019

Objective:
Apricots are mostly consumed in dried form worldwide. Studies are reporting
some allergic effects of dried apricot because of its content of sulfur, which
is used in the drying process. Therefore sulphur content has been limited by
many countries. This study was conducted to determine the effects of sun-dried
apricots with different sulfur contents on nitric oxide (NO), malondialdehyde
(MDA) and glutathione (GSH) that are among the markers of oxidative stress.

Methods:
A total of 84 Wistar albino rats were divided into groups as control, sun-dried
apricot, 1000, 2000, 3000 and 4000 ppm sulfured groups. At the end of the 12th
week, rats were sacrificed under general anesthesia. NO, MDA and GSH levels
were studied at the end of the experiment from the ovarian and testicular
tissues of the rats.

Results:
No statistically significant differences were found among the groups in terms
of NO, MDA and GSH in the ovarian and testicular tissues removed from the rats

Conclusion:
We claim that sulfur amount of dried apricots is not
affect on reproductive system. This study is guiding further studies that will
be conducted against the restrictions in sulfur used in the drying process of
dried apricots, which is economically very important for dried fruits sector.
An Overview of Post-Legislative Scrutiny in Western Australia
Authors: Hastings Sam , Doust Kate
Published: December 2019

Twenty years ago, the House of Lords Select Committee into the Constitution focused attention back onto the concept of post-legislative scrutiny. Since then, a clear framework and momentum for systematic post-legislative scrutiny has developed which has enabled parliaments to strengthen their role in the legislative process. However, there is a dearth of academic research into post-legislative scrutiny in Australian jurisdictions. Currently, there is no clear picture of the extent of post-legislative scrutiny in Western Australia and the factors in support, and challenges in implementing, systematic review of legislation. This article examines the extent of post-legislative scrutiny conducted by or overseen by the Parliament of Western Australia. An analysis of review reports and parliamentary debates reveals the outcomes of post-legislative scrutiny by the Executive. This article also examines outcomes of post-legislative scrutiny conducted by parliament through the application of the Westminster Foundation for Democracy’s Principles of Post-Legislative Scrutiny. Finally, barriers to post-legislative scrutiny by the legislature and options for reform are explored.
Rumee Ahmed. Sharia Compliant A User’s Guide to Hacking Islamic Law. California: Stanford University Press, 2018. 247 sayfa.
Authors: AKTAŞ Ayşe
Published: December 2019

British Columbia Üniversitesi’nde İslam Hukuku bölümünde öğretim

üyesi olan ve hukuk, teoloji, felsefe ve hermenötik gibi alanlarda araştırmalarını

sürdüren Rumee Ahmed, burada değerlendirilecek Sharia Compliant

A User’s Guide to Hacking Islamic Law adlı eseri dışında İslam hukuku

alanı ile ilgili Narratives of Islamic Legal Theory, The Oxford Handbook of

Islamic Law, The Objectives of Islamic Law adlı kitapların da müellifidir.

Sharia Compliant’ta İslam toplumunda süregelen yanlışlıkların aslında

toplumun tümünde gözlemlenen hususlar olduğuna değinen yazara göre

Müslüman toplumda birçok şeyin yanlış olmasının ana sebebi, İslam’ın

düzgünce yaşanmaması ve İslam hukukunun doğru kullanılamamasıdır.

Ona göre İslam hukuku düzgünce uygulansa anlatılan toplumsal problemler

ortadan kalkacaktır.
ESTADO, DIREITO E JUSTIÇA EM MARX
Authors: Albinati Ana Selva
Published: December 2019

O propósito desse trabalho é apresentar as considerações de Marx acerca do Estado, do direito e da justiça, sistematizando algumas passagens da obra do autor sobre essa relação e procurando salientar a sua originalidade frente à tradição do pensamento filosófico.
DIALÉTICA DO INACABAMENTO: 150 ANOS DO LIVRO I DE O CAPITAL
Authors: Paula João Antonio de
Published: December 2019

A partir do caráter incompleto da obra econômica de Marx, o texto in­vestiga o sentido de se considerar o seu pensamento um todo acabado. Vários críticos, ao longo da história do marxismo, apontaram o fato de que Marx teria enfrentado impasses metodológicos no final de sua trajetória, como se tivesse vivido uma “crise criativa”. O artigo analisa as visões dessa derrota científica e indica as possibilidades de superação de visões em geral estreitas sobre a incom­pletude, para pensar o sentido de uma posição marxista na contemporaneidade.
Electrical Characterization of CIGS Thin Film Solar Cells by Two and Four-Wires Probe Technique
Authors: Mosavi Amir , Beszedes Bertalan , Felde Imre , Nadai Laszlo , Gorji Nima E
Published: December 2019

The characterization of thin-film solar cells is of huge importance for obtaining high open-circuit voltage and low recombination rates from the interfaces or within the bulk of the main materials. Among the many electrical characterization techniques, the two- and four-wire probe using the Cascade instrument is of interest since the resistance of the wires, and the electrical contacts can be excluded by the additional two wires in 4-wire probe configuration. In this paper, both two and four-point probes configuration are employed to characterize the CIGS chalcogenide thin-film solar cells. The two-wire probe has been used to measure the current-voltage characteristics of the cell which results in a huge internal resistance. Therefore, the four-wire connection is also used to eliminate the lead resistance to enhance the characterization’s accuracy. The load resistance in the two-wire probe diminishes the photogenerated current density at smaller voltage ranges. In contrast, the proposed four-wire probe collects more current at higher voltages due to enhanced carrier collection efficiency from contact electrodes. The current conduction mechanism is also identified at every voltage region represented by the value of the ideality factor of that voltage region. It is observed that a long time given to the charge collection results in increased current density at a higher voltage. According to the results and device characteristics, a novel double-diode model is suggested to extract the saturation current density, shunt and series resistances and the ideality factor of the cells. These cells are shown to be efficient in terms of low recombination at the interfaces and with lower series resistance as the quality of the materials is in its most possible conductive form. The measured internal resistance and saturation current density and ideality factor of the two measurement configuration is measured and compared.
Lorentz Symmetry Group, Retardation, and Galactic Rotation Curves
Authors: Yahalom Asher
Published: December 2019

The general theory of relativity (GR) is known to be invariant under smooth coordinate transformations (diffeomorphism). This group has a subgroup known as the Lorentz group of symmetry which is manifested in the weak field approximation to GR. The dominant operator in the weak field equation of GR is thus the d'Alembert (wave) operator which has a retarded potential solution. Galaxies are huge physical systems having dimensions of many tens of thousands of light years. Thus any change at the galactic center will be noticed at the rim only tens of thousands of years later. Those retardation effects are neglected in present day galactic modelling used to calculate rotational velocities of matter in the rims of the galaxy and surrounding gas. The significant differences between the predictions of Newtonian instantaneous action at a distance and observed velocities are usually explained by either assuming dark matter or by modifying the laws of gravity (MOND). In this paper we will show that taking general relativity seriously without neglecting retardation effects one can explain the radial velocities of galactic matter in the M33 galaxy without postulating dark matter.
Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program
Authors: Sica Antonello , de Rimini Maria Luisa , Casale Beniamino , Sagnelli Caterina , Spada Alessandro , Reginelli Alfonso , Calogero Armando , Amarelli Cristiano , Maiello Ciro , Sagnelli Evangelista , Belfiore Maria Paola , Cappabianca Salvatore
Published: December 2019

The incidence of cancer in organ transplant patients is higher than in the non-transplanted population. The incidence increases with increasing age. The use of Fludeoxyglucose positron emission tomography/CT (PET/CT) is sensitive and specific to detect PTLD LD compared with conventional CT imaging. We analyzed the medical data of 127 patients aged over 60 years, who underwent heart transplantation in the above period, who have been practicing early CT-PET for diagnostic purposes between February 2007 and October 2018. Of 127 consecutive patients who underwent CT-PET, SUVs up than 4, were found in 84 patients of which 20 were affected by PTLDs, seven patients were affected by chronic non neoplastic inflammatory diseases, the remainder were affected by other neoplasms. The favorable effect of physical activity programs on cardiorespiratory and psychomotor function occur in all patients. In conclusion, CT-PET at the first doubts about the possibility of the development of neoplasms has allowed a diagnosis and then a treatment more quickly. Education in behavioral norms that improve the patient's quality of life is necessary.
New SiO2/Caffeic Acid Hybrid Materials: Synthesis, Spectroscopic Characterization and Bioactivity
Authors: Catauro Michelina , Barrino Federico , Dal Poggetto Giovanni , Crescente Giuseppina , Piccolella Simona , Pacifico Severina
Published: December 2019

Sol-gel route represents a valuable technique to obtain functional materials, in which organic and inorganic members are closely connected. Herein four hybrid materials, containing caffeic acid entrapped in a silica matrix at 5, 10, 15 and 20 wt%, were synthesized and characterized through FT-IR and UV-Vis spectroscopy. FT-IR analysis was also performed to evaluate the ability to induce the hydroxyapatite nucleation. Despite some structural changes occurred on the phenol molecular skeleton, hybrid materials showed scavenging properties vs DPPH and ABTS+ radicals, which was dependent on the tested dose and on the caffeic acid wt%. Finally, the SiO2/caffeic acid materials have been proposed as valuable antibacterial agents against Escherichia coli and Enterococcus faecalis.
Genome Editing for the Understanding and Treatment of Cardiomyopathies
Authors: Nguyen Quynh , Lim Kenji Rowel Q. , Yokota Toshifumi
Published: December 2019

Cardiomyopathies are diseases of heart muscle, a significant percentage of which are genetic in origin. Cardiomyopathies can be classified as dilated, hypertrophic, restrictive, arrhythmogenic right ventricular or left ventricular non-compaction, although mixed morphologies are possible. A subset of neuromuscular disorders, notably Duchenne and Becker muscular dystrophies, are also characterized by cardiomyopathy aside from skeletal myopathy. The global burden of cardiomyopathies is certainly high, necessitating further research and novel therapies. Genome editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as increasingly important technologies in studying this group of cardiovascular disorders. In this review, we discuss the applications of genome editing in the understanding and treatment of cardiomyopathy. We also describe recent advances in genome editing that may help improve these applications, and some future prospects for genome editing in cardiomyopathy treatment.
Exosome Release of Drugs: Coupling with Epithelial-Mesenchymal Transition
Authors: Eguchi Takanori , Ono Kisho , Calderwood Stuart , Okamoto Kuniaki
Published: December 2019

Extracellular vesicles (EVs), such as exosomes or oncosomes are released with molecules unfavorable for survival from cells. In addition, accumulating evidence has shown that tumor cells often eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistance. The EV-releasing, drug resistance phenotype is often coupled with cellular dedifferentiation and transformation, cells undergoing epithelial-mesenchymal transition (EMT) and taking on a cancer stem cell phenotype. Recent studies have shown that the release of EVs is also involved in immunosuppression. The concept of the resistance-associated secretory phenotype (RASP) is reviewed herein.
Cancer Stem Cell Plasticity – A Deadly Deal
Authors: Archana P. T. , Kritika Saxena , Murali Reshma , Jolly Mohit Kumar , Nair Radhika
Published: December 2019

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed Cancer Stem Cells (CSCs) are primarily responsible for this diversity resulting in therapeutic resistance and metastasis. Adding to this complexity, recent studies have shown that there can be different subpopulations of CSCs with varying biochemical and biophysical traits resulting in varied dissemination and drug-resistance potential. Moreover, cancer cells can exhibit a high level of plasticity or the ability to dynamically switch between CSC and non-CSC states or among different subsets of CSCs. The molecular mechanisms underlying such plasticity has been under extensive investigation and the trans-differentiation process of Epithelial to Mesenchymal transition (EMT) has been identified as a major contributing factor. Besides genetic and epigenetic factors, CSC plasticity is also shaped by non-cell-autonomous effects such as the tumor microenvironment. In this review, we discuss the recent developments in understanding CSC plasticity in tumor progression at biochemical and biophysical levels, and the latest in silico approaches being taken for characterizing cancer cell plasticity with implications in improving existing therapeutic approaches.
DAKTILITAS KURVATUR PENAMPANG KOLOM BETON BERTULANG TERKEKANG CINCIN BAJA
Authors: Safitri Endah
Published: December 2019

Struktur perlu didesain mempunyai daktilitas yang tinggi agar mendapatkan struktur yang relatif kuat menahan beban gempa (earthquake resistant building). Pada elemen beton bertulang, pengekangan efektif pada elemen struktur yang menerima gaya aksial tekan dominan yaitu kolom. Kekangan yang umum dipakai selama ini pada kolom adalah internal confinement. Paper ini membahas tentang external confinement sebagai alternatif lain dari pengekangan kolom. Sebagai external confinement dipakai tabung silinder baja yang dipotong dengan lebar tertentu sehingga mirip cincin baja. Efek kekangan yang berbeda pada beton didapat dari  variasi nilai rasio volumetrik cincin baja. Daktilitas kurvatur meningkat seiring dengan semakin besarnya rasio volumetrik  cincin baja. Hal ini dikarenakan semakin besar rasio volumetrik cincin baja, maka  daerah kekangan semakin luas sehingga beton mampu berdeformasi lebih besar. Meningkatnya kemampuan beton dalam berdeformasi ini akan meningkatkan daktilitas beton. Kenaikan optimum daktilitas kurvatur penampang kolom beton bertulang terkekang cincin baja tercapai pada rasio volumetrik 1,85%.

Kata kunci: daktilitas kurvatur, kekangan, kolom beton bertulang
Book of Abstracts: 4th International Congress on Health Sciences and Technology Organized by the School of Health Technology, Federal University of Technology (FUTO), Owerri, Imo State, Nigeria, 7-9 August, 2019
Authors: Orimadegun Adebola E. , Faloye Adeyem E. , Okafor Afoma L. , Banigo Alma T. , Ezirim Amanda U. , Chukwu Anya , Declan Augusta C. , Usman Blessing A. R. , Aghanwa C. G. , Obodo C. J. , Talla Carol , Ogbonna Chidinma P. , Anozie Chinonso I. , Okey-Mbata Chioma C. , Eke Chisomaga , Tinsley Chris , Ugwuda Christian U. , Oyamienlen Christopher S. , Okeke Chukwubike U. , Onyema Clifford T. , Okorocha Cyrilgentle U. , Amadi D. O. , Izunwanne Desmond I. , Mbanu-Jackson Dowell O. , Ibe Ebereoma , Ozioko Ejike , Nwanya Emmanuel , Chibuike Emmanuel T. , Oparaocha Evangeline T. , Arukalam Felicity M. , Ogunusi Folashade A.T. , Alimigbe Francis , Whezum Fredrick , Obokon Gabriel O. , Okafor Geraldine C. , Ndubuka Gideon I. , Uloneme Godwin C. , Orji Goodness A. , Orji Goodness N. , Iwuoha Greg N. , Meribe Ifeoma V. , Dozie Ikechukwu N. S. , Ekezie Jervas , Onah Jude , Udensi Justina U. , Ejeta Kennedy O. , Nkuma-Udah Kenneth I. , Obasi Kingsley U. , Omeaku Maris A. , Uloko Mary , Echeta Maryrose O. , Okafor Michael V. O. , Adegboye Motunrayo E. , Abu-Lail Nehal I. , Sixtus Okafor , Udoka Okeke C. , Igwe Okereke K. , Ogunkunle Oludare , Olowolafe Oludare , Ojo Oluwatosin , Chukwudi Onwuchekwa , Ujowundu Onyekachi C. , Williams Osuchukwu , Agbasi Patrick U. , Olum Princess C. , Isreal Princewil C. , Nweze Regina N. , Iwuji Samuel C. , Uzoechi Samuel C. , Umeh Sarah I. , Okafor Sixtus A. , Kolade Socrates , Eyarefe Stephen O. , Azeez Taofik A. , Azeez Taofik O. , Anele Theresa , Emmanuel Tochukwu C. , Dozie Ugonma W. , Nze Ugorji T. , Enejoh Victor , Okafor Wilson C.
Published: December 2019

© 2019 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Simulation of direct mapped, k-way and fully associative cache on all pairs shortest paths algorithms
Authors: Prihozhy A. A.
Published: December 2019

Caches are intermediate level between fast CPU and slow main memory. It aims to store copies of frequently used data and to reduce the access time to the main memory. Caches are capable of exploiting temporal and spatial localities during program execution. When the processor accesses memory, the cache behavior depends on if the data is in cache: a cache hit occurs if it is, and, a cache miss occurs, otherwise. In the last case, the cache may have to evict other data. The misses produce processor stalls and slow down the computations. The replacement policy chooses a data to evict, trying to predict the future accesses to memory. The hit and miss rate depends on the cache type: direct mapped, set associative and fully associative cache. The least recently used replacement policy serves the sets. The miss rate strongly depends on the executed algorithm. The all pairs shortest paths algorithms solve many practical problems, and it is important to know what algorithm and what cache type match best. This paper presents a technique of simulating the direct mapped, k-way associative and fully associative cache during the algorithm execution, to measure the frequency of read data to cache and write data to memory operations. We have measured the frequencies versus the cache size, the data block size, the amount of processed data, the type of cache, and the type of algorithm. After comparing the basic and blocked Floyd-Warshall algorithms, we conclude that the blocked algorithm well localizes data accesses within one block, but it does not localize data dependencies among blocks. The direct mapped cache significantly loses the associative cache; we can improve its performance by appropriate mapping virtual addresses to physical locations.
Hydrology objects monitoring system
Authors: Kuzmich A. I. , Baranovski O. V. , Valvachev A. N.
Published: December 2019

The article deals with the results of the development of monitoring system of potentially dangerous hydro-objects. The formal statement of the problem, models of the monitoring scene and its participants are presented. The scene is initially focused on the gradual replacement of participants-people on systems with artificial intelligence. The models are unified and can be refined to the level of program code. On the basis of models the proactive algorithm of monitoring providing fixing of dangerous situations at an initial stage of their emergence and operational synthesis of the corresponding managing decisions is constructed. The algorithm uses a knowledge base containing formalized expert knowledge about the features of the observed objects and resources of the regional administration to combat catastrophic phenomena.

To automate the solution, a hardware and software system using domestic intelligent sensors has been developed. Programs are written in the console version, require a minimum of computing resources. The peculiarity of the system is to minimize the time of decision-making and reducing their subjectivity by reducing the role of the human factor.

The complex is intended for use in areas where possible floods of water bodies with disastrous consequences.
Gender Differences in Treatments and Interventions Received for Children and Adolescents with Cerebral Palsy
Authors: Josenby Annika Lundkvist , Czuba Tomasz , Schmidt Ann I Alriksson
Published: December 2019

Background: In the Swedish population-based follow-up program and national quality registry for individuals with cerebral palsy (CPUP), physiotherapy (PT) and occupational therapy (OT) treatments are regularly recorded along with functional status. By Swedish law, all citizens irrespective of personal characteristics or socioeconomic status have the right to receive healthcare and medical treatments as applicable. Previous research has shown gender differences in treatments and interventions received by children with cerebral palsy (CP). The purpose of this study was to examine differences in treatments and interventions by gender and place of birth in children and adolescents participating in CPUP. Methods: This was a cross-sectional registry study. Data from the latest PT (n = 2635) and OT assessment forms (n = 3480) in CPUP were extracted for individuals aged 0-17 years. Logistic regressions were used to assess the relationships between the outcome variables and gender and place of birth (including an interaction term gender X place of birth), adjusted for age, Gross Motor Function Classification System (GMFCS) levels and spasticity scores for PT interventions and Manual Ability Classification System (MACS) for OT interventions. Results: Results are presented as odds ratios [95% confidence intervals] and p-values. Girls were significantly more likely to have spinal braces than boys; 1.54 [1.07, 2.22] p<0.05, a significant interaction with place of birth indicated fewer spinal braces prescribed to children born outside of the Nordic countries; 0.20 [0.079, 0.53] p<0.001. Girls were less likely to have undergone selective dorsal rhizotomy (SDR); 0.49 [0.25, 0.94] p<0.05. Individuals born outside of the Nordic countries, were significantly less likely to have received intrathecal baclofen (ITB) 0.27 [0.074, 0.98] p<0.05. Conclusions Of the treatments prescribed, gender differences were observed for spinal braces and having undergone SDR. A statistically significant difference based on place of birth was noted for spinal bracing and having received ITB treatment. Other PT and OT treatments were associated with age, levels of spasticity, and functional severity as classified with the GMFCS and the MACS. Increased awareness of differences based on gender, and where a child is born, could be obtained by inter- and intraprofessional discussions.
Genome-wide comparative analysis of the BAHD superfamily in seven Rosaceae species and expression analysis in pear (Pyrus☓ bretschneideri)
Authors: Liu Chunxin , Qiao Xin , Li Qionghou , Zeng Weiwei , Wei Shuwei , Wang Xin , Chen Yangyang , Wu Xiao , Wu Jun , Yin Hao , Zhang Shaoling
Published: December 2019

Background: The BAHD acyltransferase superfamily exhibits various biological roles in plants, including regulating fruit quality, catalytic synthesizing of terpene, phenolics and esters, and improving stress resistance. However, the copy numbers, expression characteristics and associations with fruit aroma formation of the BAHD genes remain unclear. Results: In total, 717 BAHD genes were obtained from the genomes of seven Rosaceae , ( Pyrus bretschneideri , Malus domestica , Prunus avium , Prunus persica , Fragaria vesca , Pyrus communis and Rubus occidentalis ). Based on the detailed phylogenetic analysis and classifications in model plants, we divided the BAHD family genes into seven groups, I-a, I-b, II-a, II-b, III-a, IV and V. An inter-species synteny analysis revealed the ancient origin of BAHD superfamily with 78 syntenic gene pairs were detected among the seven Rosaceae species. Different types of gene duplication events jointly drive the expansion of BAHD superfamily, and purifying selection dominates the evolution of BAHD genes supported by the small Ka/Ks ratios . Based on the correlation analysis between the ester content and expression levels of BAHD genes at different developmental stages, four candidate genes were selected for verification as assessed by qRT-PCR. The result implied that Pbr020016.1 , Pbr019034.1 , Pbr014028.1 and Pbr029551.1 are important candidate genes involved in aroma formation during pear fruit development. Conclusion: We have thoroughly identified the BAHD superfamily genes and performed a comprehensive comparative analysis of their phylogenetic relationships, expansion patterns, and expression characteristics in seven Rosaceae species, and we also obtained four candidate genes involved in aroma synthesis in pear fruit . These results provide a theoretical basis for future studies of the specific biological functions of BAHD superfamily members and the improvement of pear fruit quality. Keywords : BAHD, pear, evolution, Rosaceae, transcriptome, volatile esters
Extensive antimicrobial resistance and plasmid-carrying resistance genes mcr-1-positive E. coli sampled in swine, in Guangxi, South China
Authors: Yuan Jingzhi , Wang Xiaoye , Shi Dali , Ge Qiang , Song Xingxing , Hu Wen , Wei Deyuan , Ge Chenling , Li Xun , Hu Chuanhuo
Published: December 2019

Background: The discovery of the superbug mcr-1 -positive Escherichia coli (MCRPEC) has attracted worldwide attention. Swine-origin multi-drug resistant MCRPEC is a potential threat to public health and safety. To date, few detailed studies have been reported on swine MCRPEC in Guangxi, South China. Results: In this study, thirty-three MCRPEC strains were identified from 142 E. coli strains isolated from swine in Guangxi in 2018. All MCRPEC isolates were classified into eight unique STs and a total of six incompatibility plasmid groups (IncFI, IncHI1, IncY, IncN, IncI1 and IncX1) were found. Then, susceptibility of MCRPEC isolates to 27 antimicrobial agents belonging to 17 antimicrobial categories was tested. There were nineteen 3rd and 4th generation cephalosporins resistant E. coli and twelve carbapenem resistant E. coli among the 33 MCRPEC strains. Importantly, the MCRPEC were highly resistant to two carbapenem antibiotics, imipenem and meropenem, which were not permitted for use in livestock production. Three MCRPEC strains were further identified to be extensively drug-resistant (XDR), and the other isolates were recognized as multi-drug-resistant (MDR). Moreover, in order to detect whether the acquired antimicrobial resistance genes coexisted with the mcr-1 gene of the MCRPEC isolates, 22 acquired antimicrobial resistance genes were tested in total plasmid genes of MCRPEC isolates . At last, β-lactamase antimicrobial resistance genes such as ESBL genes ( bla CTX-M14 , bla CTX-M24 , bla CTX-M123 , bla OXA-1 ), plasmid-mediated AmpC (pAmpC) gene ( bla CMY-2 ), and the carbapenem gene bla NDM-5 were detected. In addition, non-β-lactamase antimicrobial resistance genes such as qnrA , qnrB , qnrS , aac(6’)-Ib-cr , tetA , tetB , sul1 , sul2 , floR , aadA were also detected. Conclusion: Thirty-three mcr-1 -positive E. coli isolates in Guangxi had a wide range of antimicrobial resistance. Plasmids carrying resistance genes might be the main cause of MCRPEC multidrug resistance. This study highlights the necessity for long-term surveillance of mcr-1 -positive E. coli in pigs.
A comparative study of mothers of infants hospitalized in an open ward neonatal intensive care unit and a combined pod and single-family room design
Authors: Feeley Nancy , Robins Stephanie , Genest Christine , Stremler Robyn , Zelkowitz Phyllis , Charbonneau Lyne
Published: December 2019

Background: The well-being of mothers of infants requiring Neonatal Intensive Care Unit (NICU) hospitalization may be affected by the architectural design of the unit. A few recent studies suggest there may be some drawbacks of single-family rooms (SFRs) for infants and their mothers, such as isolation of mothers and reduced exposure to auditory stimulation for infants. Purpose: To compare NICU-stress, symptoms of depression, perceptions of nurse-parent support and family-centered care, sleep disturbances, breastfeeding self-efficacy and readiness for discharge in mothers of infants cared for in an open ward (OW) to those cared for in a unit that includes both pods and SFRs. Methods: A pre-post quasi-experimental study was conducted in a Canadian level 3 unit before and after transitioning to a new unit of 6-bed pods and SFRs. OW data were collected in 2014 and pod/SFR data one year after the transition in 2017 to 2018. Mothers of infants hospitalized for at least 2 weeks completed questionnaires about stress, depressive symptoms, support, family-centered care, and sleep disturbances. In the week prior to discharge, they responded to breastfeeding self-efficacy and readiness for discharge questionnaires. They described their presence in the NICU at enrollment and again prior to discharge. Results: Pod/SFR mothers reported significantly less NICU-stress compared to OW mothers. OW mothers had greater sights and sounds stress and felt more restricted in their parental role. Pod/SFR mothers reported greater respect from staff. Controlling for maternal education, pod/SFR mothers perceived their infant’s readiness for discharge to be greater than OW mothers. There were no significant differences between groups in depressive symptoms, nurse-parent support, sleep disturbances, and breastfeeding self-efficacy. At enrollment and again in the weeks preceding discharge, pod/SFR mothers were present significantly more hours per week than OW mothers, controlling for maternal education. Conclusions: Further study of small pods is indicated as these units may be less stressful for parents, and enhance family-centered care, as well as maternal presence, compared to OWs.
Transcriptome analysis reveals the roles of stem nodes in cadmium transport to rice grain
Authors: Liu Ailing , Zhou Zhibo , Yi Yake , Chen Guanghui
Published: December 2019

Background: Node is the central organ of transferring nutrients and ions in plants. Cadmium (Cd) induced crop pollution threatens the food safety. Breeding of low Cd accumulation cultivar is a chance to resolve this universal problem. This study was performed to identify tissue specific genes involved in Cd accumulation in different rice stem nodes. Panicle node and the first node under panicle (node I) were sampled in two rice cultivars: Xiangwanxian No. 12 (low Cd accumulation cultivar) and Yuzhenxiang (high Cd accumulation cultivar). RNA-seq analysis was performed to identify differentially expressed genes (DEGs) and microRNAs. Results: Xiangwanxian No. 12 had lower Cd concentration in panicle node, node I and grain compared with Yuzhenxiang , and node Ⅰ had the highest Cd concentration in the two cultivars. RNA seq analysis identified 4,535 DEGs and 70 miRNAs between the two cultivars. Most genes related to the “transporter activity”, such as OsIRT1 , OsNramp5, OsVIT2 , OsNRT1.5A, and OsABCC1 , play roles in blocking the upward transport of Cd. Among the genes related to “response to stimulus”, we identified OsHSP70 and OsHSFA2d/B2c in Xiangwanxian No. 12 , but not in Yuzhenxiang , were all down-regulated by Cd stimulus. The up-regulation of miRNAs ( osa-miR528 and osa-miR408 ) in Xiangwanxian No. 12 played a potent role in lowering Cd accumulation via down regulating the expression of candidate genes, such as bZIP , ERF , MYB , SnRK1 and HSPs . Conclusions: Both panicle node and node I of Xiangwanxian No. 12 played a key role in blocking the upward transportation of Cd, while node I played a critical role in Yuzhenxiang . Distinct expression patterns of various transporter genes such as OsNRT1.5A, OsNramp5, OsIRT1, OsVIT2 and OsABCC1 resulted in differential Cd accumulation in different nodes. Likewise, distinct expression patterns of these transporter genes are likely responsible for the low Cd accumulation in Xiangwanxian No. 12 cultivar . MiRNAs drove multiple transcription factors, such as OsbZIPs, OsERFs, OsMYBs , to play a role in Cd stress response.