bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP
Authors: Fernández Diego , Louzao M. , Fraga María , Vilariño Natalia , Vieytes Mercedes , Botana Luis
Published: January 2014

Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves. These toxins cause diarrheic shellfish poisoning (DSP) in humans shortly after the ingestion of contaminated seafood. Studies carried out in mice indicated that DSP poisonous are toxic towards experimental animals with a lethal oral dose 2–10 times higher than the intraperitoneal (i.p.) lethal dose. The focus of this work was to study the absorption of OA, DTX1 and DTX2 through the human gut barrier using differentiated Caco-2 cells. Furthermore, we compared cytotoxicity parameters. Our data revealed that cellular viability was not compromised by toxin concentrations up to 1 μM for 72 h. Okadaic acid and DTX2 induced no significant damage; nevertheless, DTX1 was able to disrupt the integrity of Caco-2 monolayers at concentrations above 50 nM. In addition, confocal microscopy imaging confirmed that the tight-junction protein, occludin, was affected by DTX1. Permeability assays revealed that only DTX1 was able to significantly cross the intestinal epithelium at concentrations above 100 nM. These data suggest a higher oral toxicity of DTX1 compared to OA and DTX2.
Better Outcomes of Peritoneal Dialysis in Diabetic Patients in Spite of Risk of Loss of Autonomy for Home Dialysis
Authors: Cotovio P. , Rocha A. , Carvalho M.J. , Teixeira L. , Mendonça D. , Cabrita A. , Rodrigues A.
Published: January 2014

Introduction

Diabetes mellitus is a leading cause of chronic renal failure, challenging therapy strategies. Patients with diabetes may benefit from peritoneal dialysis (PD) but higher technique failure is feared. Our purpose was to critically evaluate clinical outcomes of this modality in diabetics, in order to find quality improvement strategies in these risk patients.

Methods

A registry-based study of 432 incident patients, 23% with diabetes, from a university hospital PD program was performed. Traditional methods (Kaplan-Meier, Cox models) and innovative survival analysis, taking competing risks into account, were performed, as well as exploring the trends in cohorts according to the decade of PD start.

Results

In spite of the detrimental effect of diabetes in patient survival compared to non-diabetics (77%, 52% vs 86%, 71%, at 2 and 4 years, respectively; p < 0.0001) the hazard ratio (HR) for death decreased in the more contemporary cohort (0.303, 95% confidence interval (CI) 0.150 – 0.614, p < 0.001). It is noteworthy that diabetes was not associated with lower technique survival: 74%, 51% vs 79%, 57%, at 2 and 4 years, respectively ( p = not significant (NS)). On multivariate analysis, diabetes was an independent predictor for mortality, but not for technique failure. The hazard ratio (HR) for technique failure also decreased in the more recent cohort (0.566, 95% CI 0.348 – 0.919, p = 0.021). Among reasons for transfer to hemodialysis, proportion of ultrafiltration failure was similar between groups (26% vs 22%, p = NS), but drop-out due to loss of autonomy occurred more in the group with diabetes (23% vs 5%, p = 0.004), mainly due to ischemic stroke. The hospitalization rate was also higher in diabetic patients (1.39 vs 0.84 episodes per patient-year (E/PY), p = 0.004) but the peritonitis rate was not increased (0.53 vs 0.61 E/PY, p = NS).

Conclusion

PD was an effective long-term renal replacement therapy in diabetics, without higher rates of technique failure, ultrafiltration failure or peritonitis. Better outcomes were achieved in the contemporary cohort. The menace of autonomy loss due to stroke and higher hospitalization rates enhance the need for assisted PD strategies and better control of comorbidities.
Effects of Post-Discharge Nurse-Led Telephone Supportive Care for Patients with Chronic Kidney Disease Undergoing Peritoneal Dialysis in China: A Randomized Controlled Trial
Authors: Li Juan , Wang Huizhen , Xie Hongzhen , Mei Guiping , Cai Wenzhi , Ye Junsheng , Zhang Jianlin , Ye Guirong , Zhai Huimin
Published: January 2014

Background

Patients with end-stage renal failure (ESRF) need integrated health care to maintain a desirable quality of life. Studies suggest that post-discharge nurse-led telephone support has a positive effect for patients suffering from chronic diseases. But the post-discharge care is under-developed in mainland China and the effects of post-discharge care on patients with peritoneal dialysis have not been conclusive.

Aim

The purpose of this study is to test the effectiveness of postdischarge nurse-led telephone support on patients with peritoneal dialysis in mainland China.

Methods

A randomized controlled trial was conducted in the medical department of a regional hospital in Guangzhou. 135 patients were recruited, 69 in the study group and 66 in the control group. The control group received routine hospital discharge care. The study group received post-discharge nurse-led telephone support. The quality of life (Kidney Disease Quality of Life Short Form, KDQOL-SF), blood chemistry, complication control, readmission and clinic visit rates were observed at three time intervals: baseline before discharge (T1), 6 (T2) and 12 (T3) weeks after discharge.

Results

Statistically significant effects were found for symptom/problem, work status, staff encouragement, patient satisfaction and energy/fatigue in KDQOL-SF and 84-day (12-week) clinic visit rates between the two groups. The study group had more significant improvement than the control group for sleep, staff encouragement at both T2 and T3, and pain at T2 and patient satisfaction at T3. No significant differences were observed between the two groups for the baseline measures, other dimensions in KDQOL-SF, blood chemistry, complication control, readmission rates at all time intervals and clinic visit rates at the first two time intervals.

Conclusions

Post-discharge nurse-led telephone support for patients undergoing peritoneal dialysis is effective to enhance patients’ well-being in the transition from hospital to home in mainland China.
The Role of Monitoring Gentamicin Levels in Patients with Gram-Negative Peritoneal Dialysis-Associated Peritonitis
Authors: Tang Wen , Cho Yeoungjee , Hawley Carmel M. , Badve Sunil V. , Johnson David W.
Published: January 2014

Background

There is limited available evidence regarding the role of monitoring serum gentamicin concentrations in peritoneal dialysis (PD) patients receiving this antimicrobial agent in gram-negative PD-associated peritonitis.

Methods

Using data collected in all patients receiving PD at a single center who experienced a gram-negative peritonitis episode between 1 January 2005 and 31 December 2011, we investigated the relationship between measured serum gentamicin levels on day 2 following initial empiric antibiotic therapy and subsequent clinical outcomes of confirmed gram-negative peritonitis.

Results

Serum gentamicin levels were performed on day 2 in 51 (77%) of 66 first gram-negative peritonitis episodes. Average serum gentamicin levels on day 2 were 1.83 ± 0.84 mg/L with levels exceeding 2 mg/L in 22 (43%) cases. The overall cure rate was 64%. No cases of ototoxicity were observed. Day-2 gentamicin levels were not significantly different between patients who did and did not have a complication or cure. Using multivariable logistic regression analysis, failure to cure peritonitis was not associated with either day-2 gentamicin level (adjusted odds ratio (OR) 0.96, 95% confidence interval (CI) 0.25 – 3.73) or continuation of gentamicin therapy beyond day 2 (OR 0.28, 0.02 – 3.56). The only exception was polymicrobial peritonitis, where day-2 gentamicin levels were significantly higher in episodes that were cured (2.06 ± 0.41 vs 1.29 ± 0.71, p = 0.01). In 17 (26%) patients receiving extended gentamicin therapy, day-5 gentamicin levels were not significantly related to peritonitis cure.

Conclusion

Day-2 gentamicin levels did not predict gentamicin-related harm or efficacy during short-course gentamicin therapy for gram-negative PD-related peritonitis, except in cases of polymicrobial peritonitis, where higher levels were associated with cure.
Stability of the Combination of Ceftazidime and Cephazolin in Icodextrin or PH Neutral Peritoneal Dialysis Solution
Authors: Patel Rahul P. , Shastri Madhur D. , Bakkari Mohammad , Wanandy Troy , Jose Matthew D.
Published: January 2014

Introduction

The objective of this study was to investigate the stability of ceftazidime and cephazolin in a 7.5% icodextrin or pH neutral peritoneal dialysis (PD) solution.

Methods

Ceftazidime and cephazolin were injected into either a 7.5% icodextrin or pH neutral PD bag to obtain the concentration of 125 mg/L of each antibiotic. A total of nine 7.5% icodextrin or pH neutral PD bags containing ceftazidime and cephazolin were prepared and stored at 1 of 3 different temperatures: 4°C in a domestic refrigerator; 25°C at room temperature; or 37°C (body temperature) in an incubator. An aliquot was withdrawn immediately before (0 hour) or after 12, 24, 48, 96, 120, 144, 168 and 336 hours of storage. Each sample was analyzed in duplicate for the concentration of ceftazidime and cephazolin using a stability-indicating high-performance liquid chromatography technique. Ceftazidime and cephazolin were considered stable if they retained more than 90% of their initial concentration. Samples were also assessed for pH, colour changes and evidence of precipitation immediately after preparation and on each day of analysis.

Results

Ceftazidime and cephazolin in both types of PD solution retained more than 90% of their initial concentration for 168 and 336 hours respectively when stored at 4°C. Both of the antibiotics lost more than 10% of the initial concentration after 24 hours of storage at 25 or 37°C. There was no evidence of precipitation at any time under the tested storage conditions. Change in the pH and color was observed at 25 and 37°C, but not at 4°C.

Conclusion

Premixed ceftazidime and cephazolin in a 7.5% icodextrin or pH neutral PD solution is stable for at least 168 hours when refrigerated. This allows the preparation of PD bags in advance, avoiding the necessity for daily preparation. Both the antibiotics are stable for at least 24 hours at 25 and 37°C, permitting storage at room temperature and pre-warming of PD bags to body temperature prior to its administration.
Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
Authors: Chentsova Anna , Kapourani Era , Giannis Athanassios
Published: January 2014

In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated processes.
Una entrevista con Hermanfrid Schubart, Moraira (Alicante, 14-XI-2012)
Authors: Risch Roberto
Published: January 2014

Hermanfrid Schubart ha sido uno de los arqueólogos más activos e influyentes del siglo XX en el ámbito de la Prehistoria de la Península Ibérica. Su labor no sólo ha supuesto la excavación e investigación de una serie de yacimientos destacados de las Edades del Cobre, el Bronce y el Hierro, sino también un importante impulso metodológico para la arqueología desde su convicción que solo el desarrollo de intervenciones extensivas en asentamientos y un enfoque pluridisciplinar pueden acercarnos a la organización de las sociedades prehistóricas. En esta entrevista conversamos durante algo más de una hora sobre su experiencia profesional y sobre el Instituto Arqueológico Alemán de Madrid desde una perspectiva científica, pero también política
Las necrópolis protohistóricas tumulares de Cataluña meridional: el ejemplo de Sebes (Flix, Tarragona)
Authors: Belarte Maria Carme , Malgosa Assumpció , Noguera Jaume , Olmos Pau , Piga Giampaolo
Published: January 2014

Se presentan los resultados de las recientes intervenciones arqueológicas realizadas en la necrópolis del Hierro I de Sebes (Flix, Tarragona). Se ha precisado la extensión de la necrópolis, su duración, los rituales funerarios y la estructura social de la población mediante técnicas y métodos de carácter interdisciplinar (antropología, carbono 14, prospecciones geofísicas…). Se ha constatado la coexistencia de túmulos y urnas y la agrupación de las estructuras en dos áreas. Sobre esta base se pretende mejorar el conocimiento de las necrópolis de cremación en un territorio de contacto entre diferentes tradiciones de enterramiento. Se dan a conocer datos inéditos procedentes del estudio antropológico de los huesos cremados de Sebes y de las dataciones radiocarbónicas de algunos de ellos. Estos datos, considerados en conjunto con los del resto de la necrópolis, permiten relacionarla más con las necrópolis tumulares leridanas que con las del Bajo Aragón - Terra Alta.
Cronología radiocarbónica de Las Lunas (Yuncler, Toledo), un gran poblado de fines de la Prehistoria en la Meseta Sur
Authors: Urbina Martinez Dionisio , García-Vuelta Oscar
Published: January 2014

Presentamos cinco fechas radiocarbónicas correspondientes a las fases del Bronce Final e inicios de la Edad del Hierro del asentamiento de Las Lunas (Yuncler, Toledo). Tres de ellas corresponden a los momentos iniciales del poblamiento y se asocian con un destacado depósito de objetos de bronce. Las otras dos remiten a los momentos finales de la ocupación prehistórica del poblado. La coincidencia de las tres primeras fechas sitúa con bastante exactitud la deposición del conjunto metálico a mediados del siglo X a.C., aportando nueva información para el estudio de los contactos a larga distancia de la población del centro de la Península Ibérica durante este período.
El conjunto de dataciones evidencia que ya había poblados de gran extensión en un horizonte cultural posterior a Cogotas I y anterior al Hierro I. Este horizonte es prácticamente desconocido en la región.
Prediction of Selected Production Goals by Classification Methods
Authors: Jurovatá Dominika , Važan Pavel , Kebisek Michal , Tanuska Pavol , Hrčka Lukáš
Published: January 2014

The goal of this work was to use the process of knowledge discovery in planning and control of production processes. This work is focused on the prediction of the system behavior from the data of production process. The classification was used as a task of data mining. Some predictive models were created and the predictions of the production process behavior were realized by varying the input parameters using selected methods and techniques of data mining. It can be confirmed that the selected input parameters will lead to the fulfillment of the declared objectives of the process. The process of knowledge discovery has been implemented in the program STATISTICA Data Miner.
Interactive Game Supporting SMED Method
Authors: Bárdy Marek , Kudrna Jiří , Šrámková Barbora , Edl Milan
Published: January 2014

The aim of this interactive game is a thorough insight into industrial engineering method called SMED (Single Minute Exchange of Die). This method is focused on reducing changeover time of machines or lines. The rapid changeover is nowadays one of the most important issues ensuring a sufficient flexibility of an enterprise. SMED game is designed for a flexible usage in terms of number of players involved in the game and length of playing time. Specifically, it is usable for one to twelve players and playing time can be set from one to four hours. Main goal of the game is an application of entire conception of SMED method.
System of Designing Complex Technical Means Using Fuzzy Analysis
Authors: Gwiazda Aleksander
Published: January 2014

This paper presents the concept of the system adding designer work using fuzzy analysis of the notes of design requirements and solutions. Design requirements are generated basing on the proposed model of the technical mean life cycle. It includes three phases of life of a technical mean: its formation, its existence and its liquidation. In this perspective there are examined five general requirements associated with: the technical need, a man, the technical culture, the society and the environment. The design solutions are created basing on the concept of an universal structure of technical means. The structure of the system has following components: structural system, drive system and control system. Structural system is determined as the integrator of the whole structure of a complex technical mean. The drive system is secondary to the structural system. The third in the order of the systems is the control system. It is developed last so it must take into account the solutions developed for the structural system and the drive system. Generating constructional solutions is carried out in the three distinguished features of a construction: geometric, material and dynamic. The presented methodology is illustrated by the example of designing specific technical mean.
Application of Camera Image Processing to Control of Humanoid Robot Motion
Authors: Ďuriš Rastislav
Published: January 2014

The wide potential applications of humanoid robots require that the robots can move in general environment, overcome various obstacles, detect predefined objects and control of its motion according to all these parameters. The goal of this paper is address the problem of implementation of computer vision to motion control of humanoid robot. We focus on using of computer vision and image processing techniques, based on which the robot can detect and recognize a predefined color object in a captured image. An algorithm to detection and localization of objects is described. The results obtained from image processing are used in an algorithm for controlling of the robot movement.
Production of Composite Material by FDM Rapid Prototyping Technology
Authors: Novakova-Marcincinova Ludmila , Novak-Marcincin Jozef
Published: January 2014

In the paper is presented information about common and advanced materials used for manufacturing of products by Fused Deposition Modelling (FDM) rapid prototyping technology. In different rapid prototyping technologies the initial state of material can come in either solid, liquid or powder state. The current range materials include paper, nylon, wax, resins, metals and ceramics. In FDM are mainly used as basic materials ABS - Acrylonitrile Butadiene Styrene, polyamide, polycarbonate, polyethylene and polypropylene. Main part of the paper is focused on experimental production and testing of composite material produced by rapid prototyping realized by Fused Deposition Modelling (FDM) method and presents outputs of testing of ABS/glass texture material realized by authors.
Finite Element Simulation of Cutting Forces in Orthogonal Machining of Titanium Alloy Ti-6Al-4V
Authors: Kandráč Ladislav , Maňková Ildikó , Vrabel' Marek , Beňo Jozef
Published: January 2014

In this paper, a Lagrangian finite element-based machining model is applied in the simulation of cutting forces in two-dimensional orthogonal cutting of titanium Ti-6Al-4V alloy. The simulations were conducted using 2D Finite Element Method (FEM) machining simulation software. In addition, the cutting experiments were carried out under the different cutting speed, feed and tool geometry (rake angle, clearance angle and cutting edge radius). The effect of cutting speed, feed and tool geometry on cutting force were investigated. The results obtained from the finite element method (FEM) and experimental studies were compared.
Investigation of Stress State and Contact Pressures in Contact Area of Journal Bearing by Numerical Simulation
Authors: Hajdu Štefan
Published: January 2014

Goal of the paper was to investigate stress state and contact pressures in contact pair of tribological assembly by numerical simulation. This paper deals with simulation of cylindrical contact pair. One part has convex (shaft) and other one concave (hole) surface of the body. This assembly represents friction state of the plain cylindrical journal bearing. The paper includes results of stress state and contact pressures from two loading states. The first loading state includes only radial loading without effect of the torque moment and the second one includes radial loading with torque moment. If we want to know more about tribological processes we will have to know stress state in the materials loaded through contact interaction between two bodies to the last detail. This level of knowledge can be achieved just by numerical simulation. The simulation was made by CAE system ANSYS.
Trends in Cutting Materials and Tools for Hard Machining
Authors: Baránek Ivan
Published: January 2014

Based on the experiments there was investigated the tool life of various kinds of cutting materials by hard machining. Taylor equations can be used for the cutting conditions setting. The measured values of surface roughness, residual stresses and microhardness show possibility of hard machining usage in practice. In case of the white layer zone appearance this needs to be eliminated by superfinishing. The ceramic and CBN wiper inserts are the objects of further research.
Design of a Digital Positioning System with Sinusoidal Change of the Jerk
Authors: Stoychitch Mihaylo Y.
Published: January 2014

In this paper we consider design of a digital electromechanical positioning system that ensures controlled change of the jerk. A system that is formed from a load and an actuating device is used as an object. For the proposed sinusoidal change of the jerk, the appropriate changes of the acceleration, velocity and displacement were found.. The control algorithm which ensures the motion of the object with sinusoidal change of the jerk so that the requirements which are related to the maximum values of the acceleration, velocity and displacement are satisfied, is also proposed. The digital feedforward and feedback controllers that are realized this algorithm are designed. Furthermore the simulation of that system is performed, which is confirmed the proposed theory.
Influence of the CAM Parameters and Selection of End-Mill Cutter when Assessing the Resultant Surface Quality in 3D Milling
Authors: Fabian Michal , Ižol Peter , Draganovská Dagmar , Tomáš Miroslav
Published: January 2014

The paper deals with the effects of CAM data needed to produce desired quality of shaped surfaces in forming dies making. In general, the input CAM data have strong influence to the final surface quality. The shaped surfaces 3D milling has been modeled as end ball milling of the surfaces with defined inclination. The end ball milling is the most common way to finish shaped surfaces. Directions of the milling tools motion and applied cutting conditions have been used to simulate data when setting milling strategies. The resultant machined surface quality has been identified in terms of the surface roughness. The paper introduces recommendations applicable to the programming of the different types of milling strategy when producing form surfaces.
Optimization of FDM Prototypes Mechanical Properties with Path Generation Strategy
Authors: Spišák Emil , Gajdoš Ivan , Slota Ján
Published: January 2014

This paper present result of a study evaluating the influence of path generation strategy on mechanical properties of Fused Deposition Modeling (FDM) prototypes. Several scientific studies were researching the problematic of path generation and internal structure of FDM prototypes. Mostly the influence on mechanical properties was observed. This paper is aimed on determine the influence of outline number and internal air-gap on tensile strength of parts built from ULTEM 9085. For this two variables was determined the influence on built time and consumption of modeling material. Result show that proper model orientation when the orientation of load is known, can help to reduce the build time and material consumption.
Machining Capabilities of Graded Materials by Cutting Processes
Authors: Irgolic Tomaz , Cus Franci
Published: January 2014

Professional paper shows the general characteristics of graded materials, their previous industrial use and potential use of graded materials in the future. In any case, today the use of graded materials is increasing and moving from the laboratory environment into everyday use. However, the subsequent processing of the graded material remains the big unknown, and represents a major challenge for researchers and industry around the world. It could be said that the study of machinability of these materials is in its infancy and in this area are many unanswered questions. Machinability problem of graded materials was undertaken at the Faculty of Mechanical Engineering in Maribor. After a radical study of the literature and potential machining processes of graded materials, we started with the implementation of cutting processes on the workpiece. This professional paper presents the first results of the analysis, which will be used for further research and machinability study of graded materials.
Machining Performance of CBN Cutting Tools for Hard Turning of 100Cr6 Bearing Steel
Authors: Kundrák János , Ráczkövi László , Gyáni Károly
Published: January 2014

This article presents the examination of cutting performance of a low CBN content cutting tool in the case of hard turning of 100Cr6 hardened bearing steel. One of the indicators of cutting performance is the wear rate, which can be calculated as a ratio of a measurable geometric parameter of a wear form and some technological parameters (cutting time, cutting length or removed material volume). The wear of CBN cutting tools is characterized by the extent of flank wear hence the wear rates related to cutting time and removed material volume are calculated based on the measured flank wear during the cutting experiments. The alteration of wear rates as a function of flank wear and cutting speed was examined.
Improvement of a Riveting Process Capability with Application of Tools and Methods of the Quality Management
Authors: Kučerová Marta , Fidlerová Helena
Published: January 2014

Assessment of a process capability is an important area of the quality management. Quality of produced outputs depends on the quality of the process, in which product characteristics are formed. In considering the capability of the process, the ability of the process should be determined to provide the required quality of products. The required product quality has to meet customer requirements and expectations. For determination of process capability are used methods, which are based on comparing variability of selected product quality characteristics. The smaller the variability of the input factor is, the better is the process capability and therefore a better quality of product is produced. Improvement of process capability and reducing the variability of the product quality characteristics can be achieved by means of applying of statistical methods. Standards for the quality management system require the need of statistical methods application as well as other tools and techniques for improvement in business practice. It is necessary to use statistical methods in measuring, monitoring and process improvement. So can be determined the process variability, identified common and special causes of variability and in consequence to propose corrective actions. The paper describes first theoretical characteristics of capability assessment methods and tools in continuous improvement in industry praxis. With application of chosen statistical methods has been improved capability of the riveting process of clutch disk.
Evaluation of DPI Change Impact on Laser Machined Surface Quality
Authors: Knedlova Jana , Sýkorová Libuše , Pata Vladimír , Malachová Martina
Published: January 2014

The article focuses on the field of PMMA laser micromachining at change of the technological parameters. The aim was to evaluate machined surface roughness at different setting of DPI definition (number of dots paths on square inch). Commercial CO2laser Mercury L-30 by firm LaserPro, USA was used for experimental machining. Ray of laser could be focused on mark diameter d=185 mm.
Numerical Research on the Changing of the Slip-Line Field in Hard Turning of Case Hardened Steels
Authors: Szabó Gergely , Kundrák János
Published: January 2014

The article examines the change of the slip-line fields structure with the help of numerical simulation (FEM) in the case of hard turning by gradually decreasing the tool rake angle. During the examination the influencing effect of the stagnation zone on the chip removal was taken into consideration. The stagnation zone is typical of the cutting done by a negative rake angle and it is generally present in front of the tool tip.
Construction Development Using Virtual Analysis on the Example of a Roof Support
Authors: Gwiazda Aleksander
Published: January 2014

The CAD/FEM systems enable the analysis and development of any constructional solutions. They are particularly effective for the complex technical means. In this regard, investigations are conducted to develop methodological concept for the design using the virtual environment [1,2,3,4]. This paper presents the solution basing on the proposed structure of the complex technical mean consisting of three components: structural system, drive system and control system. The structural system includes the carrying and functional elements. The drive system refers to the elements responsible for activating the functions of technical means. However, the control system is responsible for the implementation of the selected sequence of actions. Basing on such formulated concept it was presented the project of the powered roof supports with the strait-line mechanism. The work describes the results of the virtual analysis of the elaborated roof support construction. They are considering with the analysis of its functioning and with the fulfilment of the requirements consider with the human factors.
Three Dimensional Finite Element Simulation of Sheet Metal Blanking Process
Authors: Bohdal Łukasz , Kukielka Leon , Kukielka Krzysztof , Kułakowska Agnieszka , Malag Leszek , Patyk Radoslaw
Published: January 2014

The shearing process such as the blanking of sheet metals has been used often to prepare workpieces for subsequent forming operations. The use of FEM simulation is increasing for investigation and optimizing the blanking process. In the current literature a blanking FEM simulations for the limited capability and large computational cost of the three dimensional (3D) analysis has been largely limited to two dimensional (2D) plane axis-symmetry problems. However, a significant progress in modelling which takes into account the influence of real material (e.g. microstructure of the material), physical and technological conditions can be obtained by using 3D numerical analysis methods in this area. The objective of this paper is to present 3D finite element analysis of the ductile fracture, strain distribution and stress in blanking process with the assumption geometrical and physical nonlinearities. The physical, mathematical and computer model of the process are elaborated. Dynamic effects, mechanical coupling, constitutive damage law and contact friction are taken into account. The application in ANSYS/LS-DYNA program is elaborated. The effect of the main process parameter a blanking clearance on the deformation of 1018 steel and quality of the blanks sheared edge is analyzed. The results of computer simulations can be used to forecasting quality of the final parts optimization.
Problems Determining of the Mechanical Properties of Metallic Materials from the Tensile Test in the Aspect of Numerical Calculations of the Technological Processes
Authors: Malag Leszek , Kukielka Leon , Kukielka Krzysztof , Kułakowska Agnieszka , Bohdal Łukasz , Patyk Radoslaw
Published: January 2014

The increase of requirements concerning the accuracy of numerical analysis of technological processes with nonlinear contact such as drawing, cutting, embossing, burnishing rolling, thread rolling and machine cutting involves the extension of accuracy in determining workability parameters: initial yield stress σY0, plastic hardening modulus ET and true failure strain φf. Currently, those parameters are often determined in uniaxial tensile testing. Determination of the strain and stress states after the exceedance of ultimate tensile strength of the material, in the moment of stability loss (creation of the neck) constitutes the basic issue. Appearance of characteristic necking disturbs uniform, uniaxial state of stress. In the smallest intersection of the specimen there additionally appear radial stress and circumferential stress - three-dimensional state of stress is obtained. Currently used methods: Birdgman, Davidenkov-Spiridonova or Siebel do not allow calculating the values of those stress precisely enough. The paper concerns the new hybrid method of evaluating stress and strain states in the cylindrical specimen during of tension with the use of Finite Element Method (FEM).
CA Systems and Modularity Principles as Tools for Flexible and Efficient Production Systems Design
Authors: Javorova Angela
Published: January 2014

The article discusses the CA systems use and the application of the modularity principles in the design new, or modernizing existing production systems. This paper describes the principle of modularity as a tool for streamlining design. Design of system with the help of computers and assisted by programs. These allow creating 3D model design before the actual implementation. It is also possible to compile a control circuit simulation and detect and eliminate deficiencies still in design stage. In paper conclusion is illustrated design, automation of existing painting line for the varnish handles. Described principles have been applied, as well as CA systems, CATIA and FluidSim.
Innovation of Business Processes by Means of Computer-Aided Simulation
Authors: Manlig František , Šlaichová Eva , Koblasa František , Vavruška Jan
Published: January 2014

"If you don't innovate, you will not survive.This statement has been especially true over the last century. The most critical factor is the speed of implementation of the particular innovation. High demands on the quality of process control, more and more require the use of supporting tools that enable us to get complex and detailed analysis of the process. For this reason attention is being paid to computer-aided simulation tools. Use of computer-aided simulation is still not as widespread as might be expected nowadays. However, expanded use of this tool is only a matter of time. This statement is confirmed by experience from many innovation projects, where the application of such computer-aided simulation tools was not only advantageous, but even necessary. This article deals with the application of computer-aided simulation in the field of process innovation. The particular case study shows the benefits of computer-aided simulation and the necessity of the connection and integration with the traditional methods (descriptive or analytical). It describes concisely the innovation process for an example of a JIT assembly (Just in Time). The traditional methods (ABC analysis and analysis of the activities that do not add value - Non Business Value) only partially solved the task of the project. To complete it and find the right solution, it was necessary to use dynamic analysis using computer-aided simulation. In conclusion, further opportunities to use computer-aided simulation in this field are being outlined.
Material Flow Design Supported by Simulation Methods
Authors: Matúšová Miriam
Published: January 2014

Design solution of material flows planning in manufacturing systems belongs to key aspects that the project engineers must resolute. The conception and technical material flow realisation considerable define the dependability, promptness, consistence and next needed flows of work in the material flow. These necessary material flow functions influence the production quality, the amounts of production costs and the producer profitability. Follow up is starting to use the simulation methods at material flow designs and innovations. These methods are used in verification of new designs of material flows or in validation of just realised material flows. There is possibility of verification and validation usage by software Witness. Witness software simulation offers an optimal solution of problems by means. It enables to simulate working environment as well as material flows. The result is the higher efficiency of whole process and elimination of problems.
Materials Flow Analysis in the Production Process - Case Study
Authors: Królczyk Grzegorz , Legutko Stanisław , Królczyk Jolanta , Tama Ewelina
Published: January 2014

The paper presents an analysis of the materials flow in the company on the example of the production process of the selected product. The analysis was carried out in three stages. This division has enabled to take into account many factors that have a significant impact on the internal transport during production. The first step in the analysis was to determine the current situation of the flow of materials. In the second stage, the obtained data were used to develop a detailed program of internal transport, associated with the production of the considered product, and the last stage of the analysis was to identify opportunities for rationalization actions. The rationalization concerned the machine tools spatial location, the choice of handling equipment and transport tasks.
Research on Recognition Method of Handwritten Numerals Segmentation Based on B-P Neural Network
Authors: Wei Ning Fang
Published: January 2014

We propose a binarization method based pigment in the ZIP code of 24 bmp image simulation and digital identification by CCD sensors, were extracted the grid binary image of zip code box and message of the two characters binary image; analyze the image processing, which includes code frame edge detection and separation of the image binarization, denoising smoothing, tilt correction, the extraction code number, position, normalization processing, digital image thinning , character recognition feature extraction. Through testing, the recognition rate of this method can be over 90%. The recognition time of characters for character is less than 1.3 second, which means the method is of more effective recognition ability and can better satisfy the real system requirements.
Differentiability of the Energy Functional of a Class of Quasi-Linear Elliptic
Authors: Pan Xiao Li , Mu Li Hua , Chen Hui
Published: January 2014

To study the differentiability of a class of quasi-linear elliptic equations energy functional by using the embedding theorems and some other properties of generalized Sobolev spaces. According to the variation principle the energy functional of equations is expressed in some appropriate generalized Sobolev spaces, the various parts of differentiability of the energy functional of equations are discussed under certain conditions. Using Lebesgue dominated convergence theorem and embedding theorem, the energy functional of equations is proved. Finally, the overall differentiability is proved. The conclusions lay the foundation for the next step to prove the existence of the critical point of the energy functional, that is, the existence of solutions of the equations.
3D Modeling Technology in Indoor Decoration Design
Authors: Rao Shun
Published: January 2014

Nowadays, a large amount of thinking and inspiration which can't be expressed by words and drawings has been realized because of the rapid development of computer graphics. 3D is one of the technology drawn much attention in the field of interior design, in the meantime, 3D technology is also the development direction of Chinese interior design in new age. Those design concepts which can only be expressed with words will be accomplished by computer through 3D modeling technology. The interior design applying 3D technology meets psychological need of people's indoor life quality, environment atmosphere, and style.This paper made a design of the medium and small house model has been realized through the application platform of the Auto CAD, 3 D Max, Vray, and Premiere Pro.
Study of CAD & Processing Error for End-Gear with Arc Tooth
Authors: Liu Zhi Gang
Published: January 2014

This paper presents methods for determining the basic geometry of end-gear with arc tooth external diameter, width of tooth, end module, number of teeth, pressure angle, tooth, tooth clearance parameters; at the same time gives the tooth bearing strength calculation method, and the formulas to calculate the tooth shear stress, surface stress and bolt fastening force of equivalent stress is established; finally write the software error simulation analysis.
Modeling and Meshing of A320 Aircraft Rudder
Authors: Xu Jian Xin , Song Li Na
Published: January 2014

According to the present demand for aircraft components virtual design, two modeling methods of A320 aircraft rudder are proposed. One is to combine MATLAB programming and data processing functions with the practically measured point coordinate data of rudder face to gain and optimise the rudder contour. Then output the optimized curve to CATIA and fill it to gain rudder surface. The other is to obtain three views of rudder by referring to references. And make modeling with CATIA modules of Part DesignSketch Tracer and Generative Shape Design. And based on the second model the meshing method and the analysis is given. Also the process details were offered and the practical circumstances of the two methods were concluded. It will provide a model base for rudder teaching and its performance analysis and static test, improve the teaching quality and develop the students' ability of engineering practice. At the same time possible failure of rudder can be predicted in advance with virtual modeling and thus corresponding measures can be taken in time. It will improve the aircraft safety.
Study on Precessional Motion Simulation of Ballistic Missile Midcourse
Authors: Wang Hong , Tong Chuang Ming , Sun Jia Jia
Published: January 2014

This paper, in view of the important role of ballistic missile motion state tracking in anti-missile combat, analyzes the research status.Combined with the current research achievements, according to the precessional motion state of ballistic missile midcourse, this paper researches and establishes its dynamic model and the precessional motion model based on Euler angle representation. Finally, based on the three-dimensional model of ballistic missile motion, it conducts simulation and verification. The research result has a certain reference significance for target recognition of ballistic missile midcourse.
Simulation Research on Vehicle Handling Inverse Dynamics Based on Radial Basis Function Neural Networks
Authors: Yu Rui
Published: January 2014

Based on a brief review of the developing history of vehicle steering inverse dynamics, and using radial basis function neural network, the nonlinear mapping relation between lateral angular velocity and steering angle input is found. The identification results of step and sine steering angle input show that the proposed identification method is not only practical, but also with high accuracy.
Research on Shape Memory Alloy to Petroleum Industry
Authors: An Shao Yun
Published: January 2014

Shape memory alloy, which is known as "the most promising material in the 21st century", has become one of the three pillars and a commanding height of strategies for the 21st centurys social and economic development like information technology and biotechnology. In this paper, the current research situation, organizational performances, and application of shape memory alloy to petroleum industry are reviewed, so as to provide theoretical guidance for the further application and production of shape memory alloy.
Three-Dimensional Configuration in the Graphic Design
Authors: Xu Yi Xiang
Published: January 2014

The modern world is a stereo world dominated by the three-dimensional space. For a designer, the traditional plane design technique which is the design and arrangement relying solely on the graphics, texts, colors and other elements in the two-dimensional space has been unable to meet the needs of the people. A modern designers relying only on the means of expression of the two-dimensional space design has been unable to meet the current needs of practical design, and also cannot perfectly convey his unique design concepts. In this paper, by referring to a large number of related literatures, combined with the actual situation in the field of design, through comparison and investigation of a variety of methods, based on the specific concepts of the 3D shape, and combined with the thinking the actual situation of its emergence and development, the author summarizes the theoretical foundation of this new design concept. Mainly for the packaging design, book design, advertising design, the author ironically shows the practical application of 3D shape, and clearly shows the unique advantages compared with the traditional 2D design. Of course, compared with the traditional, the newly developing also has some inevitable defects.
Desk Lamp on 3D Modeling Based on Solidworks
Authors: Li Ming Xin
Published: January 2014

This paper introduces the solidworks design flow, design methods and design principles of desk lamp. And we use the ergonomics principle, analysis the function of each part of the lamp, and analyses the design of lamp components, to meet user needs in the bedroom, do practical, human nature and convenient lamp. The application shows that the use of this software can make easier the realization of the design of the parts with complex shape, raise the design efficiency,optimize the product structure and save the cost.
Chinese-English CS in Online Discourse Adaptation Model Based on Manufacturing Technology
Authors: Wang Xue Qing , Yuan Qiong Hua
Published: January 2014

Based on the linguistic Adaptation Theory of Jeff Verschueren, the Adaptation Principle explains the reasons of CS occurrence in terms of linguistic reality, social conventions, and psychological motivations. The present thesis applies the Adaptation Model based on manufacturing technology to the Chinese English CS of Chinese natives in online discourse. Based on the corpus of Chinese English CS in online discourse, the present thesis analyzes the CSs different forms, unique features and motivations of communications.
Highly-Efficient Preparation of Key Intermediate of Huperzine A
Authors: Xie Kai Ming
Published: January 2014

Huperzine A was approved for curing Alzheimers disease in the early 1990s in China. We explored a highly-efficient synthetic route for the key intermediate in the total synthesis of this natural product. Only common reagents and conditions were involved. So our new route has potential application in large-scale preparation of the key intermediate.
Study on ARP Protocol and Network Security in Digital Manufacturing
Authors: Yang Ru
Published: January 2014

Network spoofing attacks are very specialized attacks, and network security managers brought a severe test. In this paper, through the analysis of the ARP protocol works, it discusses ARP protocol ARP virus are two common attacks from the IP address to the security risks that exist in the physical address resolution process, and then analyzes in detail, and then introduces the ARP Find virus source and virus removal methods, and finally putting forward effective measures to guard against ARP virus.
Investment Decisions Based on Probability Statistics Mathematical Model in Mordern Manufacturing Engineering
Authors: Chen Li , Wang Hai Xia
Published: January 2014

With the globalization of economic development, the application of mathematics throughout the various areas of probability and statistics is the use of modern engineering, social and economic research is a core of mathematics. Mathematical modeling provides a new way of thinking to the economic problems from the economic decision-making issues mathematical model of probability and statistics in the economic field.