Impact of obesity and gender on the progression of hip and knee osteoarthrosis: An epidemiological study in the general population
Authors: Banjanin Žani , Pešević Pajčin Jadranka , Ubović Radmila 
Published: September 2013

&lt;p&gt;&lt;strong&gt;&lt;span id=&quot;page16R_mcid4195&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 1129.05px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.19592);&quot; role=&quot;presentation&quot;&gt;Introduction&lt;/span&gt;&lt;/span&gt;&lt;/strong&gt;&lt;span id=&quot;page16R_mcid4196&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 216.726px; top: 1129.05px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.15634);&quot; role=&quot;presentation&quot;&gt;&lt;strong&gt;.&lt;/strong&gt; Obesity is one of the most important risk factors for osteoarthritis (OA) of the knee. &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page16R_mcid4197&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 1149.05px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.11416);&quot; role=&quot;presentation&quot;&gt;However, notwithstanding numerous studies on this topic, the link between obesity and OA of the hip &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page16R_mcid4198&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 1169.05px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.10876);&quot; role=&quot;presentation&quot;&gt;and between OA and gender is still not clear enough. The aim of the study was to investigate the asso&lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page16R_mcid4200&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 1189.05px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.10888);&quot; role=&quot;presentation&quot;&gt;ciation between obesity, gender and degenerative joint disease of hip and knee within adult population&lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page16R_mcid4201&quot; class=&quot;markedContent&quot;&gt;&lt;br role=&quot;presentation&quot; /&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 1209.05px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.1132);&quot; role=&quot;presentation&quot;&gt;of the municipality of Lakta&amp;scaron;i.&lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page16R_mcid4202&quot; class=&quot;markedContent&quot;&gt;&lt;br role=&quot;presentation&quot; /&gt;&lt;strong&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 1238.5px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.15857);&quot; role=&quot;presentation&quot;&gt;Methods&lt;/span&gt;&lt;/strong&gt;&lt;/span&gt;&lt;span id=&quot;page16R_mcid4203&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 185.688px; top: 1238.5px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.07524);&quot; role=&quot;presentation&quot;&gt;&lt;strong&gt;.&lt;/strong&gt; The study included a retrospective analysis of a total of 5301 patients aged between 18 and 91, &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page16R_mcid4204&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 1258.5px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.07947);&quot; role=&quot;presentation&quot;&gt;treated for osteoarthritis of the spine, hip and knee during the period from January 1st 2005 to September &lt;span id=&quot;page18R_mcid4205&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 117.728px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.08892);&quot; role=&quot;presentation&quot;&gt;15th 2010. Out of 7089 OA of spine, hip and knee, 1169 were OA of the hip and knee. Diagnosis of OA &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4206&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 137.728px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.09182);&quot; role=&quot;presentation&quot;&gt;was based on clinical symptoms, physical examination and X-rays (78% of patients).&lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4207&quot; class=&quot;markedContent&quot;&gt;&lt;br role=&quot;presentation&quot; /&gt;&lt;strong&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 167.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.15009);&quot; role=&quot;presentation&quot;&gt;Results&lt;/span&gt;&lt;/strong&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4208&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 174.556px; top: 167.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.11306);&quot; role=&quot;presentation&quot;&gt;&lt;strong&gt;.&lt;/strong&gt; Out of 7089 spine, hip and knee OA, 1169 were hip and knee OA. Percentage of hip OA was &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4209&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 187.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.03836);&quot; role=&quot;presentation&quot;&gt;5.8% (67.9% in women and 32.1% in men). Percentage of knee OA was 10.7% (66.1% in women and 33.9% &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4210&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 207.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.08002);&quot; role=&quot;presentation&quot;&gt;in men). Among participants with Body Mass Index (BMI) above 30, 22.1% of them were with knee and &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4211&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 227.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.09679);&quot; role=&quot;presentation&quot;&gt;hip OA. Percentage of hip OA was 6.7% (67.5% in women and 32.5% in men). Percentage of knee OA &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4212&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 247.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.0608);&quot; role=&quot;presentation&quot;&gt;was 15.4% (72.4% in women and 27.6% in men). It was noticeable that there was a considerable statistical &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4213&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 267.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.10315);&quot; role=&quot;presentation&quot;&gt;significance (p&amp;lt;0.01) of the association between obesity and knee OA, whilst there was no statistically &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4214&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 287.177px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.08949);&quot; role=&quot;presentation&quot;&gt;significant (p&amp;gt;0.05) link between obesity and hip OA.&lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4215&quot; class=&quot;markedContent&quot;&gt;&lt;br role=&quot;presentation&quot; /&gt;&lt;strong&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 316.626px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.14596);&quot; role=&quot;presentation&quot;&gt;Conclusion&lt;/span&gt;&lt;/strong&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4216&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 205.122px; top: 316.626px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.08722);&quot; role=&quot;presentation&quot;&gt;&lt;strong&gt;.&lt;/strong&gt; A high BMI was significantly associated with knee OA, but not with hip OA. A significant &lt;/span&gt;&lt;/span&gt;&lt;span id=&quot;page18R_mcid4217&quot; class=&quot;markedContent&quot;&gt;&lt;span dir=&quot;ltr&quot; style=&quot;left: 118.11px; top: 336.626px; font-size: 16.6667px; font-family: serif; transform: scaleX(1.11282);&quot; role=&quot;presentation&quot;&gt;increase in the prevalence of arthritis was observed in women during menopause.&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;