bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Gender and the Specificity of Sports Activities on the Performance of Body Balance for Students of the Faculty of Physical Education and Sports
Authors: Mocanu George Danut , Murariu Gabriel , Onu Ilie , Badicu Georgian
Published: June 2022

A sense of balance is required in sports activities, conditioning the quality of movements and physical performance. (1) The purpose of the study is to investigate the influence of gender and the specificity of sports activities on body balance. The investigated participants are 157 students of the Faculty of Physical Education and Sports/Bachelor’s degree: 109 men (age = 20.49 ± 2.03, body mass index, BMI = 22.96 ± 3.20), and 48 women (age = 20.21 ± 1.51, BMI = 21.05 ± 2.78). (2) Design: Cross-sectional study, with the definition of the variables gender and sport activity with three stages (non-athletes/NA, team sports games/TSG, and individual sports/IS). The evaluation was based on four dynamic balance tests (Bass test/points, Functional reach test/cm, Fukuda test/degrees of rotation, and Walk and turn field sobriety test/errors) and three static balance tests (Flamingo test/falls, Stork test, and One-leg standing test with eyes closed/s). (3) Results: The variance analysis (multivariate and univariate tests) indicates the superiority of women in most tests applied, but with significantly better values (p < 0.05) only for the Flamingo test and Bass test. Men have superior results only for vestibular stability (Fukuda test) and One-leg standing test, but it is statistically insignificant (p > 0.05). The TSG group has slightly better values than the IS group for the whole set of tests conducted, but these are not statistically significant (p > 0.05), so we cannot highlight the certain superiority of TSG practitioners over those involved in IS. Both the TSG and the IS group outperformed all tests compared to the NA group, with significant differences (p < 0.05), especially for the TSG. Conclusion: Women have better values than men on most tests, and performance sports students have higher average scores than those in the NA group, which demonstrates the beneficial influence of specific training on static and dynamic postural stability.
Exposure to Toxic Metals and Health Risk Assessment through Ingestion of Canned Sardines Sold in Brazil
Authors: Leite Luana Carolina Santos , de Lima Nayara Vieira , Melo Elaine Silva de Pádua , Cardozo Carla Maiara Lopes , do Nascimento Valter Aragão
Published: June 2022

The presence of heavy metals in the environment is increasing, which can be a danger to public health. Fish exposed to contaminated environments tend to have higher concentrations of some metals in their tissues. Monitoring these elements remains urgent as it is a matter of global concern. Canned sardines from the Brazilian market were analyzed for elements (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Ni, Pb, Se, and Zn) of metals and metalloids, including some toxic, using inductively coupled plasma optical spectrometry (ICP OES) in two types of sardines (preserved in oil and tomato sauce) from five different brands. The results were compared to limit levels for consumption set by FAO/WHO. Moreover, we assessed the associated risk regarding the elemental intake of these elements through the samples, using the hazard quotient (HQ), hazard index (HI), and carcinogenic risk (CR). All samples had unfavorable HQ and HI, primarily due to arsenic content. In the same manner, CR for arsenic was above the proposed limit of 10−4, and cadmium and chromium, which were within the acceptable limit (10−6 to 10−4), require attention. These results show that chronic consumption of canned sardines sold in Brazil is unsafe, and quality surveillance is needed to ensure there is no risk to the population that ingests these products.
Randomized Trial on the Effects of a Group EMDR Intervention on Narrative Complexity and Specificity of Autobiographical Memories: A Path Analytic and Supervised Machine-Learning Study
Authors: Poli Andrea , Gemignani Angelo , Miccoli Mario
Published: June 2022

Narratives of autobiographical memories may be impaired by adverse childhood experiences, generating narrative fragmentation and increased levels of perceived distress. Eye movement desensitization and reprocessing (EMDR) proved to be an effective treatment to overcome traumatic experiences and to promote coherent autobiographical narratives. However, the specific mechanisms by which EMDR promotes narrative coherence remains largely unknown. We conducted a randomized controlled pilot trial (ClinicalTrials.gov Identifier NCT05319002) in a non-clinical sample of 27 children recruited in a primary school. Participants were randomly assigned to the experimental and control groups. The experimental group underwent a three-week group EMDR intervention. Subjective unit of distress (SUD), validity of cognition (VoC), classification of autobiographical memories, narrative complexity and specificity were assessed before and after the group EMDR intervention. The group EMDR intervention was able to improve SUD and VoC scales, narrative complexity and specificity, and promoted the classification of autobiographical memories as relational. The path analysis showed that SUD was able to predict VoC and narrative specificity, which, in turn, was able to predict both narrative complexity and the classification of autobiographical memories as relational. Machine-learning analysis showed that random tree classifier outperformed all other models by achieving a 93.33% accuracy. Clinical implications are discussed.
Prevalence and Associated Factors of Physical Activity among Medical Students from the Western Balkans
Authors: Grujičić Maja , Ilić Miloš , Novaković Budimka , Vrkatić Aleksandra , Lozanov-Crvenković Zagorka
Published: June 2022

The student population includes young adults who need nutrition and regular physical activity (PA) for mental, cognitive, and physical development. It is estimated that, globally, only 25–40% of the university student population is involved in regular PA. To date, no research has been conducted in the Western Balkans to address the PA of medical students. The aim of this study was to investigate the prevalence and factors influencing PA among medical students from the Western Balkans. A cross-sectional study included 2452 students from 14 medical faculties in five countries (Slovenia, Croatia, Bosnia and Herzegovina, North Macedonia and Serbia). There were significantly more students who engaged than those who did not engage in some type of regular (daily) PA. Gender, overweight or obesity, and household income are significantly associated with students’ PA. Students who are more often involved in regular daily PA and have higher daily PA levels are more likely to be males whose household income is above average. In order to improve the health of the student population, the public health authorities need to continuously investigate the PA of students and introduce appropriate activities to increase their level of PA.
Dental Care and Education Facing Highly Transmissible SARS-CoV-2 Variants: Prospective Biosafety Setting: Prospective, Single-Arm, Single-Center Study
Authors: Thurzo Andrej , Urbanová Wanda , Waczulíková Iveta , Kurilová Veronika , Mriňáková Bela , Kosnáčová Helena , Gális Branislav , Varga Ivan , Matajs Marek , Novák Bohuslav
Published: June 2022

With the arrival of the highly transmissible Omicron variants (BA.4 and BA.5), dentistry faces another seasonal challenge to preserve the biosafety of dental care and education. With the aim of protecting patients, students, teachers and healthcare professionals, this paper introduces a prospective sustainable biosafety setting for everyday dental care and education. The setting developed by dental clinicians, epidemiologists, and teachers of dentistry consists of a combination of modern technologies focused on the air-borne part of the viral pathway. The introduced biosafety setting has been clinically evaluated after 18 months of application in the real clinical environment. The protocol has three fundamental pillars: (1) UVC air disinfection; (2) air saturation with certified virucidal essences with nebulizing diffusers; (3) complementary solutions including telehealth and 3D printing. A pseudonymous online smart form was used as the evaluation method. The protocol operates on the premise that everybody is a hypothetical asymptomatic carrier. The results of a clinical evaluation of 115 patient feedbacks imply that no virus transmission from patient to patient or from doctor to nurse was observed or reported using this protocol, and vice versa, although nine patients retrospectively admitted that the clinic visit is likely to be infectious. Despite these promising results, a larger clinical sample and exposition to the current mutated strains are needed for reliable conclusions about protocol virucidal efficiency in current dental environments.
Consulting Obese and Overweight Patients for Nutrition and Physical Activity in Primary Healthcare in Poland
Authors: Znyk Małgorzata , Zajdel Radosław , Kaleta Dorota
Published: June 2022

The aim of this study was to evaluate the dietary and physical activity counseling provided to adults by family doctors. Predictors of counseling in primary healthcare were identified. A cross-sectional study was conducted from January 2020 to December 2021 among 896 adult primary care patients in the city of Łódź [Lodz], Poland. Almost 36% of the respondents were advised to change their eating habits, and 39.6% were advised to increase their physical activity. In a multivariate logistic regression analysis, people in poor health with chronic diseases related to overweight and obesity and with two, three or more chronic diseases, respectively, received advice on eating habits from their GP twice and three times more often than people in good health with no chronic conditions (OR = 1.81; p < 0.05 and OR = 1.63; p < 0.05; OR = 3.03; p < 0.001). People in the age groups 30–39 years and 40–49 years (OR = 1.71; p < 0.05 and OR = 1.58; p < 0.05), widowed (OR = 2.94; p < 0.05), with two, three or more chronic diseases (OR = 1.92; p < 0.01 and OR = 3.89; p < 0.001), and subjectively assessing overweight and obesity (OR = 1.61; p < 0.01) had a better chance of receiving advice on physical activity. The study found a higher proportion of advice on diet and physical activity provided to overweight and obese patients by primary care physicians than in other studies; however, still not all receive the necessary counseling. GPs should advise all patients not to become overweight and obese, not only those already affected by the problem.
Evaluation of Highway Hydroplaning Risk Based on 3D Laser Scanning and Water-Film Thickness Estimation
Authors: Yang Wenchen , Tian Bijiang , Fang Yuwei , Wu Difei , Zhou Linyi , Cai Juewei
Published: June 2022

Hydroplaning risk evaluation plays a pivotal role in highway safety management. It is also an important component in the intelligent transportation system (ITS) ensuring human driving safety. Water-film is the widely accepted vital factor resulting in hydroplaning and thus continuously gained researchers’ attention in recent years. This paper provides a new framework to evaluate the hydroplaning potential based on emerging 3D laser scanning technology and water-film thickness estimation. The 3D information of the road surface was captured using a vehicle-mounted Light Detection and Ranging (LiDAR) system and then processed by a wavelet-based filter to remove the redundant information (surrounding environment: trees, buildings, and vehicles). Then, the water film thickness on the given road surface was estimated based on a proposed numerical algorithm developed by the two-dimensional depth-averaged Shallow Water Equations (2DDA-SWE). The effect of the road surface geometry was also investigated based on several field test data in Shanghai, China, in January 2021. The results indicated that the water-film is more likely to appear on the rutting tracks and the pavement with local unevenness. Based on the estimated water-film, the hydroplaning speeds were then estimated to represent the hydroplaning risk of asphalt pavement in rainy weather. The proposed method provides new insights into the water-film estimation, which can help drivers make effective decisions to maintain safe driving.
We Need Engaged Workers! A Structural Equation Modeling Study from the Positive Organizational Psychology in Times of COVID-19 in Chile
Authors: Mendoza-Llanos Rodolfo , Acuña-Hormazábal Álvaro , Pons-Peregort Olga
Published: June 2022

The COVID-19 pandemic has substantially impacted mental health—workers at institutions are not exempt. In our research, from positive organizational psychology, specifically from the healthy and resilient organization (HERO) model, we analyzed the relationship between healthy organizational practices–engagement and workers’ burnout, and evaluated the mediation role of engagement between healthy organizational practices and worker burnout levels during the COVID-19 pandemic, through structural equation models of a cross-sectional survey-based study. We collected data from a sample of 594 Chilean workers. Our results of the correlations and structural equations demonstrate the relationship between PHOs with engagement (β = 0.51; p < 0.001) and burnout (β = −0.44; p < 0.001), in addition to the mediating effect of engagement between HOP with burnout (β = −0.66; p < 0.001). In conclusion, our findings suggest that healthy organizational practices promoted worker engagement and decreased worker burnout during the COVID-19 pandemic, contributing to the postulates of the HERO model. In addition, we were able to visualize a similar scenario, which showed that burnout during a pandemic decreases when worker engagement mediates the relationship with HOP.
Improving Access to Cancer Treatment Services in Australia’s Northern Territory—History and Progress
Authors: Taylor Emma V. , Thackrah Rosalie D. , Thompson Sandra C.
Published: June 2022

Cancer is the leading cause of death in the Northern Territory (NT), Australia’s most sparsely populated jurisdiction with the highest proportion of Aboriginal people. Providing cancer care to the NT’s diverse population has significant challenges, particularly related to large distances, limited resources and cultural differences. This paper describes the developments to improve cancer treatment services, screening and end-of-life care in the NT over the past two decades, with a particular focus on what this means for the NT’s Indigenous peoples. This overview of NT cancer services was collated from peer-reviewed literature, government reports, cabinet papers and personal communication with health service providers. The establishment of the Alan Walker Cancer Care Centre (AWCCC), which provides radiotherapy, chemotherapy and other specialist cancer services at Royal Darwin Hospital, and recent investment in a PET Scanner have reduced patients’ need to travel interstate for cancer diagnosis and treatment. The new chemotherapy day units at Alice Springs Hospital and Katherine Hospital and the rapid expansion of tele-oncology have also reduced patient travel within the NT. Access to palliative care facilities has also improved, with end-of-life care now available in Darwin, Alice Springs and Katherine. However, future efforts in the NT should focus on increasing and improving travel assistance and support and increasing the availability of appropriate accommodation; ongoing implementation of strategies to improve recruitment and retention of health professionals working in cancer care, particularly Indigenous health professionals; and expanding the use of telehealth as a means of delivering cancer care and treatment.
Social Network Analysis of COVID-19 Sentiments: 10 Metropolitan Cities in Italy
Authors: Fernandez Gabriela , Maione Carol , Yang Harrison , Zaballa Karenina , Bonnici Norbert , Carter Jarai , Spitzberg Brian H. , Jin Chanwoo , Tsou Ming-Hsiang
Published: June 2022

The pandemic spread rapidly across Italy, putting the region’s health system on the brink of collapse, and generating concern regarding the government’s capacity to respond to the needs of patients considering isolation measures. This study developed a sentiment analysis using millions of Twitter data during the first wave of the COVID-19 pandemic in 10 metropolitan cities in Italy’s (1) north: Milan, Venice, Turin, Bologna; (2) central: Florence, Rome; (3) south: Naples, Bari; and (4) islands: Palermo, Cagliari. Questions addressed are as follows: (1) How did tweet-related sentiments change over the course of the COVID-19 pandemic, and (2) How did sentiments change when lagged with policy shifts and/or specific events? Findings show an assortment of differences and connections across Twitter sentiments (fear, anger, and joy) based on policy measures and geographies during the COVID-19 pandemic. Results can be used by policy makers to quantify the satisfactory level of positive/negative acceptance of decision makers and identify important topics related to COVID-19 policy measures, which can be useful for imposing geographically varying lockdowns and protective measures using historical data.
Probable Bruxism and Psychological Issues among Dental Students in Serbia during the COVID-19 Pandemic
Authors: Kolak Veljko , Pavlovic Maja , Aleksic Ema , Biocanin Vladimir , Gajic Milica , Nikitovic Ana , Lalovic Marija , Melih Irena , Pesic Dragana
Published: June 2022

The COVID-19 pandemic has drastically changed the routine way of life, having consequences in many segments of life, including dental practice and education. The aim of this study was to evaluate the frequency of probable bruxism in a sample of dental students in Serbia and to estimate the potential association between psychological factors related to the COVID-19 pandemic and the presence of bruxism. A cross-sectional study included 178 dental students in Serbia, who were interviewed using a specially-designed self-administered online questionnaire, which consisted of three sections, and after that, a clinical examination for the presence of bruxism symptoms in the oral cavity. Psychological status was evaluated using the Depression, Anxiety and Stress Scale-21 (DASS-21) and the Fear of COVID-19 Scale (FCV-19S). Saliva samples were taken to analyze salivary cortisol levels. The prevalence of probable bruxism was 34.8%. Respondents with probable bruxism had significantly higher DASS-21 and FCV-19S scores and mean values of salivary cortisol compared to non-bruxers. A history of COVID-19 infection, high stress, and fear of COVID-19 scores were associated with the presence of probable bruxism. The findings suggest that the COVID-19 pandemic has had a great psychological impact and impact on the presence and worsening of bruxism symptoms in a sample of dental students in Serbia.
Geographic Knowledge Graph Attribute Normalization: Improving the Accuracy by Fusing Optimal Granularity Clustering and Co-Occurrence Analysis
Authors: Yin Chuan , Zhang Binyu , Liu Wanzeng , Du Mingyi , Luo Nana , Zhai Xi , Ba Tu
Published: June 2022

Expansion of the entity attribute information of geographic knowledge graphs is essentially the fusion of the Internet’s encyclopedic knowledge. However, it lacks structured attribute information, and synonymy and polysemy always exist. These reduce the quality of the knowledge graph and cause incomplete and inaccurate semantic retrieval. Therefore, we normalize the attributes of a geographic knowledge graph based on optimal granularity clustering and co-occurrence analysis, and use structure and the semantic relation of the entity attributes to identify synonymy and correlation between attributes. Specifically: (1) We design a classification system for geographic attributes, that is, using a community discovery algorithm to classify the attribute names. The optimal clustering granularity is identified by the marker target detection algorithm. (2) We complete the fine-grained identification of attribute relations by analyzing co-occurrence relations of the attributes and rule inference. (3) Finally, the performance of the system is verified by manual discrimination using the case of “landscape, forest, field, lake and grass”. The results show the following: (1) The average precision of spatial relations was 0.974 and the average recall was 0.937; the average precision of data relations was 0.977 and the average recall was 0.998. (2) The average F1 for similarity results is 0.473; the average F1 for co-occurrence analysis results is 0.735; the average F1 for rule-based modification results is 0.934; the results show that the accuracy is greater than 90%. Compared to traditional methods only focusing on similarity, the accuracy of synonymous attribute recognition improves the system and we are capable of identifying near-sense attributes. Integration of our system and attribute normalization can greatly improve both the processing efficiency and accuracy.
3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2
Authors: Le Nabec Anaïs , Blotas Clara , Briset Alinéor , Collobert Mégane , Férec Claude , Moisan Stéphanie
Published: June 2022

The human genome is covered by 8% of candidate cis-regulatory elements. The identification of distal acting regulatory elements and an understanding of their action are crucial to determining their key role in gene expression. Disruptions of such regulatory elements and/or chromatin conformation are likely to play a critical role in human genetic diseases. Non-syndromic hearing loss (i.e., DFNB1) is mostly due to GJB2 (Gap Junction Beta 2) variations and DFNB1 large deletions. Although several GJB2 cis-regulatory elements (CREs) have been described, GJB2 gene regulation remains not well understood. We investigated the endogenous effect of these CREs with CRISPR (clustered regularly interspaced short palindromic repeats) disruptions and observed GJB2 expression. To decipher the GJB2 regulatory landscape, we used the 4C-seq technique and defined new chromatin contacts inside the DFNB1 locus, which permit DNA loops and long-range regulation. Moreover, through ChIP-PCR, we determined the involvement of the MEIS1 transcription factor in GJB2 expression. Taken together, the results of our study enable us to describe the 3D DFNB1 regulatory landscape.
Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification
Authors: Felix-Ilemhenbhio Favour , Pickering George A. E. , Kiss-Toth Endre , Wilkinson Jeremy Mark
Published: June 2022

The term heterotopic ossification (HO) describes bone formation in tissues where bone is normally not present. Musculoskeletal trauma induces signalling events that in turn trigger cells, probably of mesenchymal origin, to differentiate into bone. The aetiology of HO includes extremely rare but severe, generalised and fatal monogenic forms of the disease; and as a common complex disorder in response to musculoskeletal, neurological or burn trauma. The resulting bone forms through a combination of endochondral and intramembranous ossification, depending on the aetiology, initiating stimulus and affected tissue. Given the heterogeneity of the disease, many cell types and biological pathways have been studied in efforts to find effective therapeutic strategies for the disorder. Cells of mesenchymal, haematopoietic and neuroectodermal lineages have all been implicated in the pathogenesis of HO, and the emerging dominant signalling pathways are thought to occur through the bone morphogenetic proteins (BMP), mammalian target of rapamycin (mTOR), and retinoic acid receptor pathways. Increased understanding of these disease mechanisms has resulted in the emergence of several novel investigational therapeutic avenues, including palovarotene and other retinoic acid receptor agonists and activin A inhibitors that target both canonical and non-canonical signalling downstream of the BMP type 1 receptor. In this article we aim to illustrate the key cellular and molecular mechanisms involved in the pathogenesis of HO and outline recent advances in emerging molecular therapies to treat and prevent HO that have had early success in the monogenic disease and are currently being explored in the common complex forms of HO.
Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology
Authors: Katam Ramesh , Lin Chuwei , Grant Kirstie , Katam Chaquayla S. , Chen Sixue
Published: June 2022

In the past two decades, the post-genomic era envisaged high-throughput technologies, resulting in more species with available genome sequences. In-depth multi-omics approaches have evolved to integrate cellular processes at various levels into a systems biology knowledge base. Metabolomics plays a crucial role in molecular networking to bridge the gaps between genotypes and phenotypes. However, the greater complexity of metabolites with diverse chemical and physical properties has limited the advances in plant metabolomics. For several years, applications of liquid/gas chromatography (LC/GC)-mass spectrometry (MS) and nuclear magnetic resonance (NMR) have been constantly developed. Recently, ion mobility spectrometry (IMS)-MS has shown utility in resolving isomeric and isobaric metabolites. Both MS and NMR combined metabolomics significantly increased the identification and quantification of metabolites in an untargeted and targeted manner. Thus, hyphenated metabolomics tools will narrow the gap between the number of metabolite features and the identified metabolites. Metabolites change in response to environmental conditions, including biotic and abiotic stress factors. The spatial distribution of metabolites across different organs, tissues, cells and cellular compartments is a trending research area in metabolomics. Herein, we review recent technological advancements in metabolomics and their applications in understanding plant stress biology and different levels of spatial organization. In addition, we discuss the opportunities and challenges in multiple stress interactions, multi-omics, and single-cell metabolomics.
Immunological Responses to Cancer Therapy
Authors: Fransen Marieke F.
Published: June 2022

The use of immunotherapy for cancer has taken flight in the last two decades, from experimental therapy envisioned mainly by laboratory scientists to everyday treatment used by physicians to treat many patients [...]
Recombinant Cathepsin L of Tribolium castaneum and Its Potential in the Hydrolysis of Immunogenic Gliadin Peptides
Authors: Dvoryakova Elena A. , Klimova Maria A. , Simonyan Tatiana R. , Dombrovsky Ivan A. , Serebryakova Marina V. , Tereshchenkova Valeriia F. , Dunaevsky Yakov E. , Belozersky Mikhail A. , Filippova Irina Y. , Elpidina Elena N.
Published: June 2022

Wheat gliadins contain a large amount of glutamine- and proline-rich peptides which are not hydrolyzed by human digestive peptidases and can cause autoimmune celiac disease and other forms of gluten intolerance in predisposed people. Peptidases that efficiently cleave such immunogenic peptides can be used in enzyme therapy. The stored product insect pest Tribolium castaneum efficiently hydrolyzes gliadins. The main digestive peptidase of T. castaneum is cathepsin L, which is from the papain C1 family with post-glutamine cleavage activity. We describe the isolation and characterization of T. castaneum recombinant procathepsin L (rpTcCathL1, NP_001164001), which was expressed in Pichia pastoris cells. The activation of the proenzyme was conducted by autocatalytic processing. The effects of pH and proenzyme concentration in the reaction mixture on the processing were studied. The mature enzyme retained high activity in the pH range from 5.0 to 9.0 and displayed high pH-stability from 4.0 to 8.0 at 20 °C. The enzyme was characterized according to electrophoretic mobility under native conditions, activity and stability at various pH values, a sensitivity to various inhibitors, and substrate specificity, and its hydrolytic effect on 8-, 10-, 26-, and 33-mer immunogenic gliadins peptides was demonstrated. Our results show that rTcCathL1 is an effective peptidase that can be used to develop a drug for the enzyme therapy of various types of gluten intolerance.
MAFLD and CKD: An Updated Narrative Review
Authors: Mantovani Alessandro , Lombardi Rosa , Cattazzo Filippo , Zusi Chiara , Cappelli Davide , Dalbeni Andrea
Published: June 2022

Accumulating evidence now indicates that non-alcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease observed in clinical practice worldwide, is independently associated with an increased risk of incident chronic kidney disease (CKD). Given that NAFLD is linked to insulin resistance, obesity and type 2 diabetes mellitus, an international panel of experts have recently proposed a name change from NAFLD to metabolic associated fatty liver disease (MAFLD). Since the diagnostic criteria for NAFLD and MAFLD are different, observational studies assessing the potential concordance (or even superiority) of MAFLD, compared with NAFLD, in detecting patients at increased risk of hepatic and extra-hepatic complications (including CKD) are required. Hence, in the last two years, some observational studies have investigated the potential relationship between MAFLD and CKD. The result is that, at present, evidence regarding the concordance or even superiority of MAFLD, compared with NAFLD, in detecting patients at higher risk of CKD is still preliminary, although some data indicate that MAFLD identifies patients with CKD as accurately as NAFLD. In this narrative review, we will discuss: (a) the epidemiological evidence assessing the association between NAFLD and risk of incident CKD, (b) the epidemiological data investigating the association between MAFLD and risk of CKD and (c) the biological mechanisms underlying the association between NAFLD/MAFLD and CKD.
Morphology of the Female Reproductive System of the Soybean Thrips, Neohydatothrips variabilis (Beach, 1896) (Thysanoptera: Thripidae)
Authors: Hameed Asifa , Ulmer Jonah M. , Miko Istvan , Rosa Cristina , Rajotte Edwin G.
Published: June 2022

Soybean thrips (Neohydatothrips variabilis) are an important phytophagous vector of the widely recognized Soybean vein necrosis orthotospovirus (SVNV). Understanding the egg-laying behavior of these thrips could aid in developing strategies for the management of the vector and virus. In this study, we described the egg-laying behavior of N. variabilis and reconstructed the three-dimensional morphology of the female terminalia by using serial block-face scanning electron microscopy (SBFSEM) and confocal laser scanning microscopy (CLSM). The female reproductive system consists of two panoistic ovaries consisting of eight ovarioles. The appendage gland is connected to the ovaries by two muscles, and to the body wall by a single muscle. The spermatheca is connected to the eighth tergum through four branched muscles, to the basivalvulae of the ovipositor by one muscle and to the vagina by a single muscle. The external genitalia are operated by seven muscles. The movement of the eggs inside the ovipositor is achieved by the back and forth “rocking” movement of the first valvulae and valvifer. Eggs are deposited into the parenchymatous tissue alongside leaf veins. To the best of our knowledge, this is the first study describing the internal and external genitalia of N. variabilis.
Bibliometric Analysis of Trends in Mulberry and Silkworm Research on the Production of Silk and Its By-Products
Authors: Giora Domenico , Marchetti Giuditta , Cappellozza Silvia , Assirelli Alberto , Saviane Alessio , Sartori Luigi , Marinello Francesco
Published: June 2022

Traditionally, sericulture is meant as the agricultural activity of silk production, from mulberry (Morus sp.pl.) cultivation to silkworm (Bombyx mori L.) rearing. The aim of the present work is to analyze the trends and outputs of scientific research on sericulture-related topics during the last two decades, from 2000 to 2020. In this work the authors propose a text-mining analysis of the titles, abstracts and keywords of scientific articles focused on sericulture and available in the SCOPUS database considering the above-mentioned period of time; from this article collection, the 100 most recurrent terms were extracted and studied in detail. The number of publications per year in sericulture-related topics increased from 87 in 2000 to 363 in 2020 (+317%). The 100 most recurrent terms were then aggregated in clusters. The analysis shows how in the last period scientific research, besides the traditional themes of sericulture, also focused on alternative products obtainable from the sericultural practice, as fruits of mulberry trees (increment of +134% of the occurrences in the last five years) and chemical compounds as antioxidants (+233% of occurrences), phenolics (+330% of occurrences) and flavonoids (+274% of occurrences). From these considerations, the authors can state how sericulture is an active and multidisciplinary research field.
Genome-Wide Identification and Analysis of the Heat-Shock Protein Gene Superfamily in Bemisia tabaci and Expression Pattern Analysis under Heat Shock
Authors: Zheng Hao-Yuan , Qin Peng-Hao , Yang Kun , Liu Tong-Xian , Zhang You-Jun , Chu Dong
Published: June 2022

The thermal tolerance of Bemisia tabaci MED, an invasive whitefly species with worldwide distribution, plays an important role in its ecological adaptation during the invasion process. Heat-shock proteins (HSPs) are closely related to heat resistance. In this study, 33 Hsps (BtaHsps) were identified based on sequenced genome of B. tabaci MED belonging to six HSP families, among which 22 Hsps were newly identified. The secondary structures of a further 22 BtaHsps were also predicted. The results of RT-qPCR showed that heat shock could affect the expression of 14 of the 22 Hsps newly identified in this study. Among them, the expression level of six Hsps increased under 42 °C treatment. As the unstudied gene, BtaHsp90A3 had the highest increase rate. Therefore, BtaHsp90A3 was chosen for the RNAi test, and silencing BtaHsp90A3 by RNAi decreased the survival rate of adult B. tabaci at 42 °C. The results indicated that only a few Hsps were involved in the thermal tolerance of host whitefly although many Hsps would response under heat stress. This study conducted a more in-depth and comprehensive identification that demonstrates the evolutionary relationship of BtaHsps and illustrates the response of BtaHsps under the influence of thermal stress in B. tabaci MED.
A Novel Solution for Day-Ahead Scheduling Problems Using the IoT-Based Bald Eagle Search Optimization Algorithm
Authors: Alhasnawi Bilal Naji , Jasim Basil H. , Siano Pierluigi , Alhelou Hassan Haes , Al-Hinai Amer
Published: June 2022

Advances in technology and population growth are two factors responsible for increasing electricity consumption, which directly increases the production of electrical energy. Additionally, due to environmental, technical and economic constraints, it is challenging to meet demand at certain hours, such as peak hours. Therefore, it is necessary to manage network consumption to modify the peak load and tackle power system constraints. One way to achieve this goal is to use a demand response program. The home energy management system (HEMS), based on advanced internet of things (IoT) technology, has attracted the special attention of engineers in the smart grid (SG) field and has the tasks of demand-side management (DSM) and helping to control equality between demand and electricity supply. The main performance of the HEMS is based on the optimal scheduling of home appliances because it manages power consumption by automatically controlling loads and transferring them from peak hours to off-peak hours. This paper presents a multi-objective version of a newly introduced metaheuristic called the bald eagle search optimization algorithm (BESOA) to discover the optimal scheduling of home appliances. Furthermore, the HEMS architecture is programmed based on MATLAB and ThingSpeak modules. The HEMS uses the BESOA algorithm to find the optimal schedule pattern to reduce daily electricity costs, reduce the PAR, and increase user comfort. The results show the suggested system’s ability to obtain optimal home energy management, decreasing the energy cost, microgrid emission cost, and PAR (peak to average ratio).
Prenatal Diagnosis Using Chromosomal Microarray Analysis in High-Risk Pregnancies
Authors: Hsiao Ching-Hua , Chen Jia-Shing , Shiao Yu-Ming , Chen Yann-Jang , Chen Ching-Hsuan , Chu Woei-Chyn , Wu Yi-Cheng
Published: June 2022

Background: To assess the value of chromosomal microarray analysis (CMA) during the prenatal diagnosis of high-risk pregnancies. Methods: Between January 2016 and November 2021, we included 178 chorionic villi and 859 amniocentesis samples from consecutive cases at a multiple tertiary hospital. Each of these high-risk singleton pregnancies had at least one of the following indications: (1) advanced maternal age (AMA; ≥35 years; 546, 52.7%); (2) fetal structural abnormality on ultrasound (197, 19.0%); (3) high-risk first- or second-trimester Down syndrome screen (189, 18.2%), including increased nuchal translucency (≥3.5 mm; 90, 8.7%); or (4) previous pregnancy, child, or family history (105, 10.1%) affected by chromosomal abnormality or genetic disorder. Both G-banding karyotype analysis and CMA were performed. DNA was extracted directly and examined with oligonucleotide array-based comparative genomic hybridization. Results: Aneuploidies were detected by both G-banding karyotyping and CMA in 42/1037 (4.05%) cases. Among the 979 cases with normal karyotypes, 110 (10.6%) cases had copy number variants (CNVs) in CMA, including 30 (2.9%) cases with reported pathogenic and likely pathogenic CNVs ≥ 400 kb, 37 (3.6%) with nonreported VOUS, benign, or likely benign CNVs ≥ 400 kb, and 43 (4.1%) with nonreported CNVs < 400 kb. Of the 58 (5.6%) cases with aneuploidy rearrangements, 42 (4.1%) were diagnosed by both G-banding karyotyping and CMA; four inversions, six balanced translocations, and six low mosaic rates were not detected with CMA. Conclusions: CMA is an effective first step for the prenatal diagnosis of high-risk pregnancies with fetal structural anomalies found in ultrasonography or upon positive findings.
Non-Lipid Effects of PCSK9 Monoclonal Antibodies on Vessel Wall
Authors: Ugovšek Sabina , Šebeštjen Miran
Published: June 2022

Elevated low density lipoprotein (LDL) cholesterol and lipoprotein(a) (Lp(a)) levels have an important role in the development and progression of atherosclerosis, followed by cardiovascular events. Besides statins and other lipid-modifying drugs, PCSK9 monoclonal antibodies are known to reduce hyperlipidemia. PCSK9 monoclonal antibodies decrease LDL cholesterol levels through inducing the upregulation of the LDL receptors and moderately decrease Lp(a) levels. In addition, PCSK9 monoclonal antibodies have shown non-lipid effects. PCSK9 monoclonal antibodies reduce platelet aggregation and activation, and increase platelet responsiveness to acetylsalicylic acid. Evolocumab as well as alirocumab decrease an incidence of venous thromboembolism, which is associated with the decrease of Lp(a) values. Besides interweaving in haemostasis, PCSK9 monoclonal antibodies play an important role in reducing the inflammation and improving the endothelial function. The aim of this review is to present the mechanisms of PCSK9 monoclonal antibodies on the aforementioned risk factors.
Colour Duplex and/or Contrast-Enhanced Ultrasound Compared with Computed Tomography Angiography for Endoleak Detection after Endovascular Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-Analysis
Authors: Karaolanis Georgios I. , Antonopoulos Constantine N. , Georgakarakos Efstratios , Lianos Georgios D. , Mitsis Michail , Glantzounis Georgios K. , Giannoukas Athanasios , Kouvelos George
Published: June 2022

This study aims to assess the role of Color Duplex Ultrasound with or without contrast media for surveillance following endovascular aortic aneurysm repair (EVAR). A systematic search of the literature published until April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The pooled rates of endoleak detection through Contrast-Enhanced or Color Duplex Ultrasound (CEUS or CDUS) and Computed Tomography Angiography (CTA) with 95% confidence intervals (CIs) were estimated using random-effect analysis. Thirty-eight studies were considered eligible for inclusion. The total number of patients in the included studies was 5214 between 1997 and 2021. The overall pooled rate of endoleak detection using CDUS and CTA was 82.59% and 97.22%, while the rates for CEUS and CTA were 96.67% and 92.82%, respectively. The findings of the present study support the use of the CEUS for endoleak detection. However, it should be integrated into institutional protocols for EVAR surveillance to further evaluate its clinical utility in the post-EVAR period before it can be recommended as the sole imaging modality after EVAR.
Feasibility, Prediction and Association of Right Ventricular Free Wall Longitudinal Strain with 30-Day Mortality in Severe COVID-19 Pneumonia: A Prospective Study
Authors: Beyls Christophe , Ghesquières Tristan , Hermida Alexis , Booz Thomas , Crombet Maxime , Martin Nicolas , Huette Pierre , Jounieaux Vincent , Dupont Hervé , Abou-Arab Osama , Mahjoub Yazine
Published: June 2022

Introduction: Right ventricular (RV) systolic dysfunction (RVsD) is a common complication of coronavirus infection 2019 disease (COVID-19). The right ventricular free wall longitudinal strain parameter (RV-FWLS) is a powerful predictor of mortality. We explored the performance of RVsD parameters for predicting 30-day mortality and the association between RV-FWLS and 30-day mortality. Methods: COVID-19 patients hospitalized at Amiens University Hospital in the critical care unit with transthoracic echocardiography were included. We measured tricuspid annular plane systolic excursion (TAPSE), the RV S’ wave, RV fractional area change (RV-FAC), and RV-FWLS. The diagnostic performance of RVsD parameters as predictors for 30-day mortality was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC). RVsD was defined by an RV-FWLS < 21% to explore the association between RVsD and 30-day mortality. Results: Of the 116 patients included, 20% (n = 23/116) died and 47 had a RVsD. ROC curve analysis showed that RV-FWLS failed to predict 30-day mortality, as did conventional RV parameters (all p > 0.05). TAPSE (21 (19–26) mm vs. 24 (21–27) mm; p = 0.024) and RV-FAC (40 (35–47)% vs. 47 (41–55)%; p = 0.006) were lowered in the RVsD group. In Cox analysis, RVsD was not associated with 30-day mortality (hazard ratio = 1.12, CI 95% (0.49–2.55), p = 0.78). Conclusion: In severe COVID-19 pneumonia, RV-FWLS was not associated with 30-day mortality.
Sex Disparities in Outcome of Patients with Alcohol-Related Liver Cirrhosis within the Eurotransplant Network—A Competing Risk Analysis
Authors: Listabarth Stephan , König Daniel , Berlakovich Gabriela , Munda Petra , Ferenci Peter , Kollmann Dagmar , Gyöeri Georg , Waldhoer Thomas , Groemer Magdalena , van Enckevort Arjan , Vyssoki Benjamin
Published: June 2022

Alcohol use disorder (AUD) is one of the most important risk factors for the development of alcohol-related liver cirrhosis (ALC). Importantly, psychiatrists are an integral part of the interdisciplinary care for patients with AUD and ALC. The aim of the current study was to investigate whether sex influences the outcome within this group of patients. For this purpose, data of all registrations for liver transplantations due to ALC within the Eurotransplant region from 2010 to 2019 were analyzed for sex disparities using competing risk models and in-between group comparisons. Relevant sex differences in registration numbers (24.8% female) and investigated outcomes were revealed. Risk ratios for a positive outcome, i.e., transplantation (0.74), and those of adverse outcomes, i.e., removal from waiting list (1.44) and death on waiting list (1.10), indicated a relative disadvantage for female patients with ALC. Further, women listed for liver transplantations were significantly younger than their male counterparts. Notably, sex disparities found in registration and outcome parameters were independent of differences found in the prevalence of AUD and liver transplantations. Further research is necessary to identify the underlying mechanisms and establish strategies to ensure equity and utility in liver transplantations due to ALC.
Principal Parameters Analysis of the Double-Elastic-Constrained Flapping Hydrofoil for Tidal Current Energy Extraction
Authors: Zhou Junwei , Yan Wenhui , Mei Lei , Cong Lixin , Shi Weichao
Published: June 2022

Taking the rigid NACA0012 airfoil as the object, the key structural parameters of the spring–mass system that govern the dynamics of the double-elastic-constrained flapping hydrofoil are numerically studied in this paper. A two-dimensional numerical model, based on the CFD software FINE/Marine, is established to investigate the influence of the spring stiffness coefficient, frequency ratio, and damping coefficient on the motion and performance of the flapping hydrofoil. This study demonstrates that when the structural parameters are adequately adjusted, the power factor exceeding 1.0 has been achieved, and the corresponding efficiency is up to 37.8%. Moreover, this system can start and work within a wide range of damping coefficients. However, the hydraulic efficiency and power coefficient are sensitive to the change in damping coefficient, so it is very necessary to design an appropriate power output. Lastly, the most obvious parameter affecting the energy acquisition performance is the spring stiffness coefficients. Frequency ratios in the two directions have little influence on the peak value of the power coefficient, but they will cause the change of damping coefficients of the peak point. The key structural parameters studied in this paper provide a useful guideline for an optimized design of this interesting system through searching for the best performance.
Factors Affecting Risk Attitude of Rice Farmers: Evidence from Vietnam’s Mekong Delta
Authors: Dong Khuu Thi Phuong , Khoi Phan Dinh , Nhung Phan Hong , Binh Nguyen Thanh , Phuc Tran Thi Hanh
Published: June 2022

Agricultural production accounts for 64.2% of the Vietnam’s Mekong Delta. However, this sector has to face damage risks, especially from the natural disasters, such as flood, drought, severe soil salinity, pests, and erosion, which might factor into the farmers’ risk attitude and their decision-making relative to investment in production activities. This study analyzes the factors influencing the risk attitudes of the rice farmers, based on evidence from the Vietnamese Mekong Delta. The data were collected through face-to-face interviews and experimental games with 145 rice farmers. An ordered probit regression model was applied to estimate how the factors affected the rice farmers’ risk attitudes. The risk-neutral farmers comprised 53.72% of farmers in the survey, while 31.72% and 15.15% were risk-preferred and risk-averse farmers. The study results indicated that age, number of rice crops per year, household assets, income from rice production, and credit accessibility were the main factors affecting the farmers’ risk attitudes. The results suggest that the financial incentives’ policies to compensate for losses in uncertain conditions and increase the household income, diversification of income sources, and improving the accessibility of formal credit might be useful to increase farmers’ willingness to accept the risks of investing in better profitability projects and gaining a higher income.