bluuebunny/crossref_metadata_2025 huggingface dataset:
Novedades del orden Pucciniales sobre la familia Asteraceae en páramos de Antioquia (Colombia)
Authors: Vanegas-B Katherin Maritza , Salazar-Yepes Mauricio
Published: December 2018

Se presentan los Pucciniales colectados sobre la familia Asteraceae en el Páramo del Sol, Páramo Serranía las Baldías, Páramo de Sonsón y Páramo de Santa Inés, ubicados en el departamento de Antioquia (Colombia). Las colecciones parasitadas por royas fueron colectadas entre 2800 y 4050 m, identificándose un total de diez especies de royas sobre esta importante familia botánica. En los resultados se destacan: dos nuevas especies para la biota de Pucciniales: Puccinia baccharidis-antioquensis y Puccinia oritrophiae; Baeodromus eupatorii como nuevo registro de roya para Colombia; Gnaphalium antennarioides, Hieracium frigidum, Jungia ferruginea y Munnozia senecionidis como nuevos hospedantes parasitados por roya; y Puccinia alia, Puccinia gnaphaliicola y Puccinia mutisiae como nuevos registros para el departamento de Antioquia. Estos resultados amplían el conocimiento de la biota de Pucciniales colombianos, así como su distribución geográfica.
Supplementary material Article 65677. Tooth row variation in tadpoles of Dendropsophus labialis (Anura: Hylidae: Dendropsophini) and the evolution of oral morphology in the genus
Authors: Ballen Gustavo A.
Published: December 2018

Appendix S1.1. Dataset for embryos (GS 25 or younger) and referenced as “embryos.csv” in the script.Appendix S1.2. Dataset for larvae (GS 25 or older) and referenced as “larvae.csv” in the script.Appendix S2.1. iter.cor.test.R function needed for the analysis script. Written in R.Appendix S2.2. ontogeny.R script for carrying out the analyses.Appendix S3. Species of Dendropsophus and references describing oral morphology.
Ball characterizations in spaces of constant curvature
Authors: Jerónimo-Castro Jesus , Makai, Jr. Endre
Published: December 2018

High proved the following theorem. If the intersections of any two congruent copies of a plane convex body are centrally symmetric, then this body is a circle. In our paper we extend the theorem of High to spherical, Euclidean and hyperbolic spaces, under some regularity assumptions. Suppose that in any of these spaces there is a pair of closed convex sets of class C+2 with interior points, different from the whole space, and the intersections of any congruent copies of these sets are centrally symmetric (provided they have non-empty interiors). Then our sets are congruent balls. Under the same hypotheses, but if we require only central symmetry of small intersections, then our sets are either congruent balls, or paraballs, or have as connected components of their boundaries congruent hyperspheres (and the converse implication also holds).

Under the same hypotheses, if we require central symmetry of all compact intersections, then either our sets are congruent balls or paraballs, or have as connected components of their boundaries congruent hyperspheres, and either d ≥ 3, or d = 2 and one of the sets is bounded by one hypercycle, or both sets are congruent parallel domains of straight lines, or there are no more compact intersections than those bounded by two finite hypercycle arcs (and the converse implication also holds).

We also prove a dual theorem. If in any of these spaces there is a pair of smooth closed convex sets, such that both of them have supporting spheres at any of their boundary points Sd for Sd of radius less than π/2- and the closed convex hulls of any congruent copies of these sets are centrally symmetric, then our sets are congruent balls.
On ergodic properties of operator nets on the predual of von neumann algebras
Authors: Erkurşun Özcan Nazife
Published: December 2018

In this paper, we proved theorems which give the conditions that special operator nets on a predual of von Neumann algebras are strongly convergent under the Markov case. Moreover, we investigate asymptotic stability and existence of a lower-bound function for such nets.
ĐỊNH DANH CÁC LOÀI NẤM KÍ SINH VÀ GÂY BỆNH TRÊN BỆNH NHÂN NỮ NHẬP VIỆN Ở HẢI DƯƠNG BẰNG PHƯƠNG PHÁP SO SÁNH CHUỖI GEN VÀ PHÂN TÍCH PHẢ HỆ
Authors: Huy Nguyễn Xuân , Thanh Trần Văn , Hòa Lê Thanh
Published: December 2018

Sử dụng phương pháp “mã vạch” DNA (DNA-barcoding), 36 chuỗi nucleotide vùng giao gen ITS (internal transcribed spacer) từ 43 mẫu bệnh phẩm nuôi cấy nấm đơn bào của bệnh nhân nữ nhập viện ở Hải Dương đã được thu nhận và phân tích so sánh với các chủng tham chiếu quốc tế. Chuỗi ITS có độ dài khác nhau tùy từng loài (0,5 – 1,2 kb) thu thập bằng phản ứng PCR và giải trình tự (cặp mồi ITS1F/ITS4R), được sử dụng để truy cập Ngân hàng gen và xác định loài dựa trên so sánh chuỗi và phân tích phả hệ với các loài tương ứng. Kết quả cho thấy, trong số 36 mẫu thực hiện thành công giám định loài, có 29 mẫu được xác định thuộc chi Candida, trong đó 13 mẫu là loài Candida albicans, 2 mẫu là C. tropicalis, 3 mẫu là C. metapsilosis, 8 mẫu là C. glabrata, 2 mẫu là C. etchellsii và một mẫu chỉ được định danh là Candida sp. Ngoài ra, 7 mẫu còn lại gồm 2 mẫu thuộc loài Pichia kudriavzevii và Pichia norvegensis; và một số loài ít gặp khác: i) Kodamaea ohmeri; ii) Fereydounia khargensis; iii) Debaryomyces sp. (có thể là loài Debaryomyces subglobosus); iv) Hanseniaspora sp. (có thể là loài Hanseniaspora opuntiae); và v) Penicillium citrinum, với mức độ đồng nhất rất cao (99-100%). Cây phả hệ chủng/loài Candida của Việt Nam và thế giới, chia làm 7 nhóm riêng biệt, bao gồm: nhóm C. albicans, nhóm C. tropicalis, nhóm C. parapsilosis, nhóm C. metapsilosis, nhóm Candida spp., nhóm C. glabrata và nhóm C. etchellsii. Phả hệ của Pichia spp. cũng cho thấy P. kudriavzevii và P. norvegensis của Việt Nam tập hợp cùng với loài tham chiếu tương ứng. Trên một địa bàn hẹp như tỉnh Hải Dương, kết quả định danh trên bệnh nhân nhập viện đã có đến 6 loài Candida khác nhau và 7 loài đặc biệt khác cho thấy tình hình nhiễm nấm Candida và nấm đơn bào là khá phức tạp và lẫn tạp. C. albicans vẫn là một loài nấm gây bệnh nguy hiểm đang tồn tại, lan tỏa và gây bệnh phổ biến trong cộng đồng phụ nữ ở địa bàn Hải Dương nói riêng và Việt Nam nói chung.
XÂY DỰNG PROBE ĐỂ KHAI THÁC VÀ CHỌN GEN MÃ HÓA XYLAN 1-4 BETA XYLOSIDASE TỪ DỮ LIỆU GIẢI TRÌNH TỰ DNA METAGENOME
Authors: Giang Nguyễn Minh , Huyền Đỗ Thị , Nguyệt Phùng Thu , Trung Nguyễn Thị , Hải Trương Nam
Published: December 2018

Theo phân loại của CAZy, xylan 1-4 beta xylosidase thuộc họ glycoside hydrolase (GH) 1, 3, 31, 39, 43,51, 52, 54, 116, 120. Trong nghiên cứu này, probe được xây dựng dựa trên các trình tự axit amin của enzyme này từ mỗi họ GH đã được nghiên cứu trong thực nghiệm. Các trình tự thu thập để xây dựng probe đảm bảo cùng có nguồn gốc từ vi khuẩn, có các thông tin chi tiết về hoạt tính enzyme, nhiệt độ và pH hoạt động tối ưu. Kết quả các họ GH1, GH3 chỉ tìm được duy nhất 01 trình tự, GH52 tìm được 3 trình tự và GH43 tìm được 11 trình tự đáp ứng các tiêu chí thu thập. Với kết quả tìm kiếm này, chỉ có duy nhấthọ GH43 có đủ số lượng trình tự đáng tin cậy để xây dựng probe. Probe của họ GH43 có độ dài là 507 amino acid, trong đó chứa toàn bộ 7 amino acid hoàn toàn giống nhau ở các trình tự, 32 vị trí giống nhau ở đa số các trình tự và có 30 vị trí giống nhau ở một số trình tự, với độ bao phủ thấp nhất là 60% và độ tương đồng thấp nhất là 30%, điểm tối đa là 17. Sử dụng probe này đã khai thác được 25 trình tự mã hóa xylan 1-4 beta xylosidase từ dữ liệu giải trình tự DNA metagenome của vi sinh vật sống tự do trong ruột mối. So sánh với kết quả chú giải gen dựa trên dữ liệu KEGG của BGI chỉ có 20 trình tự trùng nhau. Kết quả ước đoán cấu trúc bậc ba của các trình tự cho thấy tất cả các trình tự có chỉ số điểm tối đa khi so sánh với probe bằng BLASTP cao trên 100 đều có cấu trúc giống với cấu trúc của xylosidase đã được nghiên cứu. Như vậy, probe này có thể sử dụng để khai thác gen beta - xylosidase từ dữ liệu metagenome khi sử dụng chỉ số điểm tối đa trên 100
BẢO QUẢN ĐÔNG LẠNH TUYẾN TRÙNG K. SINH GÂY BỆNH CÔN TRÙNG Ở VIỆT NAM TRONG NITROGEN LỎNG
Authors: Châu Nguyễn Ngọc , Anh Đỗ Tuấn
Published: December 2018

Bảo quản đông lạnh các chủng tuyến trùng k. sinh gây bệnh côn trùng trong nitrogen lỏng là giải pháp tối ưu để duy trì bảo tồn tài nguyên tuyến trùng có lợi ở Việt Nam. Trong bảo quản đông lạnh bằng nitrogen lỏng, 2 yếu tố ảnh hưởng quan trọng đến khả năng sống và độc lực của các chủng tuyến trùng là nồng độ ấu trùng cảm nhiễm và nồng độ dung dịch Glycerol. Thử nghiệm với các nồng độ khác nhau đã xác định nồng độ tối ưu là 12.000 IJs /mL và 15% Glycerol. Trên cơ sở đó lần đầu tiên ở Việt Nam đã triển khai bảo quản đông lạnh 27 chủng tuyến trùng k. sinh gây bệnh côn trùng bản địa, bao gồm 24 chủng giống Steinernema và 3 chủng giống Heterorhabditis. Sau 72 giờ bảo quản đông lạnh, kết quả kiểm tra đã xác định tỷ lệ sống trung bình của các chủng tuyến trùng EPN là 79,2%, trong đó, 79,2% (55,6 - 95,7%) đối với các chủng Steinernema và 79% (70,1 - 86,2%) đối với các chủng Heterorhabditis. Độc lực của các chủng tuyến trùng EPN sau đông lạnh 72 giờ được xác định bằng tỷ lệ chết của ấu trùng tuổi 5 bướm sáp lớn là 71,6% (60,0 - 83,3%) ở công thức nhiễm với ấu trùng cảm nhiễm (infective juveniles - IJs) đông lạnh và 70,6% (63,6 - 80%) ở công thức đối chứng. Kết quả thử nghiệm cho thấy sau đông lạnh cho thấy sự sai khác không có . nghĩa về hiệu lực gây chết của tuyến trùng đông lạnh và không đông lạnh. Như vậy, qua đông lạnh các chủng tuyến trùng k. sinh gây bệnh côn trùng vẫn duy trì độc lực như vốn có. Quy trình bảo quản đông lạnh được xác lập và áp dụng trong nghiên cứu này có thể đáp ứng yêu cầu bảo quản đông lạnh toàn bộ mẫu tuyến trùng k. sinh gây bệnh côn trùng sống đang được lưu giữ ở Việt Nam.
ĐÁNH GIÁ HIỆU QUẢ THAY THẾ Fe-EDTA BẰNG NANO SẮT TRONG VI NHÂN GIỐNG CÂY SALEM (LIMONIUM SINUATUM (L.) MILL)
Authors: Hiền Đỗ Thị , Cường Đỗ Mạnh , Tùng Hoàng Thanh , Nam Nguyễn Bá , Luận Vũ Quốc , Nhựt Dương Tấn
Published: December 2018

Hiện nay, vi nhân giống Salem vẫn còn gặp nhiều khó khăn như: lá cây in vitro và ex vitro dễ bị hoại tử do nấm, vi khuẩn và virus nội sinh; cây con phát triển chậm, tỉ lệ sống của cây con thấp ở giai đoạn vườn ươm. Nghiên cứu này bước đầu thử nghiệm vật liệu nano sắt hóa trị 0 (nZVI) thay thế cho Fe-EDTA trong môi trường nuôi cấy in vitro cây Salem, một loại cây hoa cắt cành có giá trị cao trên thế giới, nhằm đánh giá khả năng nhân nhanh chồi, sinh trưởng cây con in vitro và thuần hóa ex vitro của cây. Kết quả thu được cho thấy, khi gia tăng nồng độ nZVI (10-200 μM) bổ sung vào môi trường cảm ứng phát sinh chồi với 0,4 mg/L BA, 0,2 mg/L NAA, hệ số nhân chồi tăng so với sử dụng Fe-EDTA sau 5 tuần nuôi cấy. Trong giai đoạn ra rễ, tốc độ tăng trưởng của cây con trên môi trường ½ MS bổ sung nZVI với 0,4 mg/L NAA kém hơn các cây trên môi trường sử dụng Fe-EDTA. Tuy nhiên, sau 4 tuần nuôi trồng ngoài vườn ươm, các cây con in vitro trên môi trường bổ sung nZVI cho hiệu quả tăng trưởng và tỷ lệ sống cao vượt trội so với đối chứng sử dụng Fe-EDTA. Nano sắt với nồng độ 50 μM bổ sung vào môi trường nuôi cấy cho hệ số nhân chồi in vitro, chiều cao cây con, trọng lượng tươi, chiều dài rễ, chỉ số chlorophyll và tỷ lệ sống sót ngoài điều kiện vườm ươm tốt nhất (8,33 chồi; 11,67 cm; 2,89 g; 5,67 cm; 24,3; 99,17%; tương ứng). Nghiên cứu này cho thấy rằng việc sử dụng nano sắt trong môi trường vi nhân giống cho hiệu quả nhân nhanh và chất lượng cây giống ex vitro tốt hơn so với sử dụng muối sắt Fe-EDTA.
BIỂU HIỆN GEN XBXS14 MÃ HÓA XYLAN 1,4-Β-XYLOSIDASE CÓ NGUỒN GỐC TỪ VI KHUẨN RUỘT MỐI COPTOTERMES GESTROI TRONG TẾ BÀO ESCHERICHIA COLI ROSETTA (DE3)
Authors: Thu Nguyễn Minh , Giang Nguyễn Minh , Như Phạm Hải , Thái Đinh Nho , Huyền Đỗ Thị , Hải Trương Nam
Published: December 2018

Khung đọc mở GL0112518 gồm 1077 nucleotide (còn gọi là Xbxs14) mã hóa xylan 1,4-β-xylosidase kiềm đã được khai thác từ dữ liệu giải trình tự DNA metagenome của vi sinh trong ruột mối. Gen được tổng hợp nhân tạo và gắn vào vector pET22b(+) để tiến hành biểu hiện enzyme dạng tái tổ hợp cho đánh giá tính chất nzyme. Kết quả cho thấy gen được biểu hiện tốt trong ba chủng E. coli BL21, Rosetta (DE3) và JM109 (DE3), trong đó hai chủng E. coli BL21, Rosetta (DE3) thu được sinh khối lớn nhưng hầu hết enzyme nằm ở pha không tan. Bằng cách thay đổi điều kiện biểu hiện bao gồm nồng độ chất cảm ứng IPTG, nhiệt độ nuôi cấy biểu hiện gen và thời gian thu mẫu, một phần nhỏ enzyme đã được biểu hiện ở dạng tan. Điều kiện thích hợp cho việc biểu hiện Xbxs14 trong chủng E. coli Rosetta (DE3) là nuôi cấy lắc trong môi trường LB, cảm ứng ở IPTG 0,05 mM, nhiệt độ 20oC trong 2 ngày. Enzyme tái tổ hợp được biểu hiện ở pha tan (soluble fraction) có hoạt tính của xylosidase, phân cắt liên kết β(1→4) glycoside ở cơ chất pNPX tạo màu vàng đặc trưng của nitrophenyl. Trong 1 lít môi trường nuôi cấy thu được 3,15 U enzyme.
USING γ RAY-INDUCED SILVER NANOPARTICLES ON CONTROL OF CLUBROOT DISEASE OF CHINESE CABBAGE CAUSED BY PLASMODIOPHORA BRASSICAE
Authors: Anh Tu Le Thi , Le Ha Pham Thi
Published: December 2018

Plasmodiophora brassicae- the casual cause of clubroot disease of plants belonging to the family Brassicaceae. This soil-borne fungus infects plants through root hairs. Diseased roots become swollen and deformed. Thus, it’s difficult for plants to absorb water and nutrients. There are some methods used to control this disease including soil fumigation, soil pH control, fungicides, surfactants applications, calcium supplementation, but the results are still restricted. Plasmodiophora brassicae was isolated, identified and artificial inoculated on the Chinese cabbage. The rate of root hair infection and gall formation depended on the spore density and growth media. The increase of the pathogen density lead to the increase of disease symptoms. Silver nanoparticles (SNPs) are widely used as an agent for antifungal treatment. The antimicrobial activity of the nanoparticles varies on the size, shape, and the function of the surface area. The γ - irradiation method to synthesize SNPs is known as a method that can be controlled the out coming sizes, shapes and size distribution of particles. The average diameter of silver nanoparticles in this research was 9.5nm. In the liquid culture and soil, SNPs exhibited a controlling effect on P. brassicae. The fungicide activity depended on the SNP concentrations and the medium; no disease symptoms were found at the SNP concentrations of 1.06 ppm in the liquid culture, and 10 and 20 ppm in soil. Results of the study also showed that the biomass and height of infected plants were much lower than those of the healthy plants. Comparing to the plants that were grown in the sterilized soil, there was not significant difference between the biomass and the height of plants exposed to pathogen and treated with SNPs.
Safety and Activity of Sorafenib in Addition to Vinflunine in Post-Platinum Metastatic Urothelial Carcinoma (Vinsor): Phase I Trial
Authors: Shah Carl-Henrik , Pappot Helle , Agerbæk Mads , Holmsten Karin , Jäderling Fredrik , Yachnin Jeffrey , Grybäck Per , von der Maase Hans , Ullén Anders
Published: December 2018

Lessons Learned

First trial to report safety and activity of the microtubule inhibitor vinflunine plus the tyrosine kinase inhibitor sorafenib in post-platinum metastatic urothelial cancer (mUC) patients. A recommended phase II dose was identified for the treatment combination of vinflunine plus sorafenib, with main adverse events including fatigue, febrile neutropenia, neutropenia, hypertension, and hyponatremia. An overall response rate of 41% to second-line vinflunine plus sorafenib treatment in patients with platinum-resistant mUC was confirmed.

Background

Platinum-progressive metastatic urothelial carcinoma (mUC) is a clinical challenge. The tyrosine kinase inhibitor sorafenib has demonstrated varied activity in mUC. This trial was designed to examine safety and activity of vinflunine plus sorafenib in mUC.

Methods

In addition to standard dose of vinflunine (320 or 280 mg/m2), patients received sorafenib (400, 600, or 800 mg/day), in a 3 + 3 dose-escalation phase I design.

Results

Twenty-two patients (median age 62.5 years) were included. Five patients received vinflunine 320 mg/m2 and 17 received 280 mg/m2. The maximum tolerated dose (MTD) of sorafenib with vinflunine 280 mg/m2 was 600 mg, and with vinflunine 320 mg/m2 it was not determined, owing to toxicity. Adverse events (AEs) grades 3 + 4 consisted of neutropenia (6 patients), febrile neutropenia (5), and hyponatremia (5). The overall response rate (ORR) in the efficacy-evaluable patients was 41% (7 of 17), all partial responses evaluated by RECIST version 1.1. Median overall survival (OS) was 7.0 months (1.8–41.7).

Conclusion

The defined recommended phase II dose (RPTD) was vinflunine 280 mg/m2 plus sorafenib 400 mg. Sorafenib was too toxic in combination with vinflunine 320 mg/m2. The ORR of 41% to this second-line combination treatment of mUC is noteworthy and supports further trials.
The facilitators and barriers encountered by South African parents regarding sensory integration occupational therapy
Authors: Smit Jacintha , de Jongh Jo-Celene , Cook Ray Anne
Published: December 2018

Differences in parent perceptions regarding occupational therapy using a sensory integration approach to treatment have been noted. The various factors that may influence these perceptions, and how the perceptions may ultimately influence the outcome of the intervention for the child and family were questioned. A phenomenological study revealed a progression that all parents perceived and experienced as the "before", "input" and "after" phases of when their child received occupational therapy/sensory integration (OT/SI). This article focuses specifically on the "input" phase of OT/SI intervention. METHOD: Participants in this study were nine parents of children with difficulties processing and integrating sensory information, who live in the Western Cape, South Africa. Using a qualitative, phenomenological approach, data were collected during face-to-face interviews, participant observation and researcher's field notes FINDINGS: The main theme related to this phase of analysis was "Just suddenly everything made so much sense". For most participants, this phase brought to light a better understanding of sensory integration disorder (SID), also known as Sensory Processing Disorder (SPD) and OT/SI. Data analysis identified two subthemes that catalysed expansion in most participants' understanding, which were the role of the occupational therapist, and the OT/SI intervention process. Within these subthemes, the facilitating factors and barriers of OT/ SI intervention emerged CONCLUSION: Insight gained from the participants' recommendations and interpretation of findings allowed recommendations to be made within the OT/SI intervention received, in an attempt to overcome the barriers and promote the facilitators that will make a difference to OT/SI in South Africa Key words: Sensory integration; sensory integration disorder (SID); sensory processing disorder (SPD); parent(s) perceptions; facilitators; barriers
A survey of occupational therapists' involvement in facilitating self-employment for people with disabilities
Authors: Monareng Luther Lebogang , Franzsen Denise , van Biljon Hester
Published: December 2018

BACKGROUND: In South Africa, occupational therapists are involved with the facilitation of people with disabilities ability to work, but the high unemployment rate in the country affects placement opportunities. Utilising the option of self-employment is a way of addressing this problem OBJECTIVE: To explore the attitude of South African occupational therapists about facilitating self-employment with their clients, their awareness of available resources that support self-employment, if therapists are offering such intervention and what they perceive their role to be within the field METHOD: The study used a quantitative cross-sectional descriptive survey design RESULTS: A positive attitude (90%) and good awareness of available resources (74%) existed amongst participating occupational therapists. Occupational therapy practices did not offer self-employment facilitation in an evidence-based manner. Therapists believed their roles were undefined within the field of self-employment, and their training did not equip them to offer such intervention CONCLUSION: Occupational Therapists agree that self-employment is a good work option for people with a disability and are aware of resources that support such endeavours. The therapeutic practice and role definition is lacking. Occupational therapists have to create evidence that enables transformational and afro-appropriate interventions, for example, self-employment for people with disabilities within their profession Key words: Self-employment, Unemployment, SMME (Small, medium and micro enterprise) and PWDs (People with disabilities)
Targeting Atrial Fibrillation Patients for Left Atrial Appendage Occlusion with Epicardial Closing Devices
Authors: Crijns Harry J ,   Maastricht University Medical Center, Maastricht, The Netherlands, Spitzer Stefan G ,   Dresden Heart and Vessels Clinic, Dresden, Germany,   Brandenburg University of Technology Cottbus-Senftenberg, Institute of Medical Technology, Dresden, Germany, Tondo Claudio ,   Heart Rhythm Center, Monzino Cardiac Center, Scientific Institute for Research and Healthcare (IRCCS), Deptartment of Clinical Sciences and Community, University of Milan, Milan, Italy
Published: December 2018

The left atrial appendage (LAA) is a key source of thrombi in patients with non-valvular atrial fibrillation (AF) and a major clinical focus for stroke prevention. Current surgical exclusion remains suboptimal and percutaneous approaches targeting the LAA, although well validated, fail to offer complete and durable occlusion for all patients. The high anatomical variability of the LAA demands a more tailored and targeted treatment approach. Epicardial LAA clip occlusion represents an important alternative approach for patients with AF not amenable to catheter closure or where anticoagulation is contraindicated. In this article, we briefly review the clinical evidence for epicardial devices in LAA occlusion, with a focus on the AtriClip and discuss their role in stroke prevention strategies.
Mechanisms of Atrial Fibrillation and Their Impact on Strategies for Catheter Ablation
Authors: Guettler Norbert ,   Internal Medicine and Cardiology, German Air Force Center for Aerospace Medicine, Fuerstenfeldbruck, Germany,   Central Military Hospital, Koblenz, Germany, Nicol Edward ,   Department of Cardiology, Royal Brompton Hospital, London, UK, Schmitt Joern ,   Department of Cardiology, University Hospital Giessen, Giessen, Germany, Rajappan Kim ,   Cardiac Department, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Published: December 2018

Atrial fibrillation (AF) is the most common sustained arrhythmia, and is ubiquitous in clinical practice. The underlying mechanisms of initiation and maintenance of AF are complex and not completely understood. This knowledge, however, is fundamental for the development of treatment strategies for AF. Within the last 20 years, catheter ablation has played an increasing role as a rhythm control therapy. Based on diverse models for the initiation and maintenance of AF, various ablation strategies have been proposed. The cornerstone of AF ablation has been pulmonary vein isolation (PVI). In persistent AF, however, PVI alone is often not sufficient. This may be because of the structural remodelling of the atria leading to dilation and fibrosis amongst other factors. The optimal strategy for substrate modification, however, is still a matter of investigation. Current studies are concentrating on the ablation of fibrotic areas, especially in the left atrium, either detected by delayed enhancement magnetic resonance imaging or by identification of low-voltage areas as a surrogate marker. The second intensely evaluated strategy is the localisation and ablation of rotational activity. Many further randomised controlled trials will likely be needed to determine the optimal ablation strategy for individual patients.
A Case of Iatrogenic Wernicke Encephalopathy Following Prolonged Total Parenteral Nutrition
Authors: ÇETİNER Mustafa , Canbaz Kabay Sibel , Ocak Özgül , Ayas Selahattin
Published: December 2018

Thiamine is a water-soluble vitamin that plays a role in the metabolism of glucose. Thiamine deficiency affects cardiovascular and nervous systems. Wernicke encephalopathy is characterized by oculomotor abnormalities, ataxia and cognitive deterioration caused by thiamine deficiency. It is most commonly observed in chronic alcoholics. It may also occur in patients who receive long-term total parenteral nutrition. In this study, we present the case of a 50-year-old male patient who underwent surgery for laryngeal cancer, who stayed in the intensive care unit for a prolonged period and received total parenteral nutrition because of the inability of oral intake.
Assessment of Hematological and Inflammatory Parameters in Patients Receiving Isotretinoin Therapy for Acne Vulgaris
Authors: YALDIZ Mahizer , ÇETİNKAYA Reyhan , SOLAK Berna
Published: December 2018

Objectives:Isotretinoin (ISO) is a synthetic analog of vitamin A used at the doses of 0.5–2 mg/kg for four to five months in the treatment of moderate to severe acne vulgaris. In the present study, both hematological and inflammatory parameters were retrospectively assessed in patients receiving ISO therapy for acne vulgaris.Method: This study included 352 patients who were admitted to the Dermatology Clinic and received oral ISO for the treatment of acne vulgaris were included in the study. Each patient’s hematological and inflammatory parameters (hemoglobin, hematocrit, thrombocyte, mean platelet volume, leukocyte, erythrocyte, neutrophil, lymphocyte, monocyte, eosinophil, basophil, neutrophil/basophil, thrombocyte/lymphocyte, RDW, PCT and PDW) were evaluated before the treatment and retrospectively evaluated four months after the onset of treatment. Results: After treatment, a significant decrease was detected in the levels of leukocyte, neutrophil and neutrophil to lymphocyte ratio (NLR) (an indicator of inflammation), and a significant increase was detected in the levels of thrombocyte and procalcitonin (PCT).Conclusion: In our study, isotretinoin inhibited the anti-inflammatory effect of isotretinoin treatment of acne in patients with NLR decline after treatment with inflammatory markers. Patients with markedly elevated platelet counts or low leukocyte counts should be closely monitored.
TANDA PEIRCEAN DAN MAKNANYA DALAM UNSUR INTRINSIK CERPEN ‘INDAMA YA’TI AL-MASA’ KARYA NAGUIB MAHFOUZ (ANALISIS SEMIOTIKA CHARLES S. PEIRCE)
Authors: Mushodiq Muhamad Agus
Published: December 2018

Penelitian ini mengkaji tentang cerita pendek yang ditulis oleh Naguib Mahfouz dengan judul ‘Indama Ya’ti al-Masa. Cerpen tersebut menceritakan tentang kehidupan sepasang sumai istri di masa tua. Mahfouz, menurut hemat peneliti berhasil menampilkan gambaran kehidupan suami istri di masa tua yang dipenuhi dengan konflik keluarga yang kompleks. Peneliti memandang bahwa cerpen tersebut mengandung banyak sekali tanda yang harus dikaji maknanya. Hal tersebut dapat dibuktikan dengan judul yang disajikan Mahfouz yang tidak bisa dimaknai dengan makna leksikal. Dengan demikian, peneliti menggunakan teori tanda yang dirumuskan oleh Charles Sanders Peirce. Peirce memandang bahwa tanda dibangun atas unsur triadik, yaitu representamen, objek, dan interpretan. Sedangkan fokus kajian pada penelitian ini ada pada kajian objek yang terdiri dari tanda ikon, indeks, dan simbol. Adapun tanda-tanda peircean yang ditemukan adalah berupa indeks, simbol, dan ikon metafora. Salah satu tanda indeks ditemukan pada kalimat /nazratan fatirah/ ‘pandangan yang lemas dan tidak bersemangat’, bermakna bahwa orang yang memberikan respon tersebut tidak setuju dengan ajakan lawan bicara. Salah satu tanda simbol terdapat pada kata /al-qabri/ ‘kuburan’ tersimpan makna kematian. Tanda ikon metafora pada kata /al-masa’/ ‘sore’ yang merujuk pada makna masa tua, mengingat terdapat kesamaan antara keduanya.
AKSES, FUNGSI, DAN POLA PENGGUNAAN TEKNOLOGI INFORMASI DAN KOMUNIKASI (TIK) OLEH PETANI PADA KAWASAN PERTANIAN KOMERSIAL DI KABUPATEN BANTUL
Authors: Christian Ade Intan , Subejo Subejo
Published: December 2018

Information and Communication Technologies (ICTs) has been considered play an important role for supporting the need of new information and innovation for farmers. Extension and communication based ICTs in developing countries can be used for wider scope of activities including information related to various farming operations. This research discusses a new trend of emergence of ICTs in Bantul Regency for supporting daily life activities of farmer including agricultural activities. Research method of study was descriptive method. In general, farmers have been using television and radio with function for getting information, entertaining, and education. However, hand phone and smart phone to some extent have emerged as additional and important alternative media for farmer. The use of internet via smartphone has newly started to be utilized among farmer in Bantul Regency. Information on agriculture which accessed by farmers was still dominated by production aspect and marketing.
ON STABILITY CONTROL OF A PARABOLIC SYSTEMS WITH DISTRIBUTED PARAMETERS ON THE GRAPH
Authors: Zhabko Alexei Petrovich , Provotorov Vyacheslav Vasil’evich , Provotorova Elena Nikolaevna
Published: December 2018

The work is an attempt to demonstrate the concept of sustainability in the undisturbed state Lyapunov differential system for equations with partial derivatives, and show the ability to use a famous classical results in the studied case.
À descoberta de recursos naturais: uma atividade de outdoor com alunos do ensino primário
Authors: Tracana Rosa Branca , Lopes Ana , Farinha Ana Maria , Ferreira Maria Eduarda
Published: December 2018

O bloco curricular À descoberta do ambiente natural, do 4º ano de escolaridade do ensino primário, abrange temáticas e/ou estratégias de outdoor learning. O ensino em contexto não formal é proporcionador de aprendizagens significativas que podem desenvolver atitudes e valores de respeito para e/ou preservação da natureza e sensibilização para os aspetos estéticos do ambiente. O meio natural necessita que a educação ambiental desencadeie sentimentos ecocêntricos nas nossas crianças, de modo a que cesse a perspetiva antropocêntrica em relação ao meio ambiente. Assim, tomando como problema de investigação perceber se estas crianças do ensino primário conheciam o recurso natural do meio onde residem, o rio Zêzere, desenvolvemos um estudo qualitatito/quantitativo, por questionário. Face aos resultatos obtidos construímos e validámos um recurso didático, um guião, cuja finalidade é a descoberta deste recurso natural através de uma atividade de outdoor.
Propuestas de formación docente para la enseñanza de las Ciencias de la Tierra en Argentina
Authors: Regalía Diego Arias , Bonan Leonor , Gonçalves Pedro Wagner
Published: December 2018

Existe consenso respecto de la necesidad de incluir la enseñanza de contenidos de las ciencias de la Tierra en los distintos niveles del sistema educativo argentino. Sin embargo, la escasísima oferta horaria asociada a la disciplina parece no haber justificado hasta ahora la existencia de titulaciones específicas. ¿Cómo formar entonces docentes que puedan enseñar estos contenidos?. Planteamos un trabajo desde la investigación-acción que implica incorporar esta cuestión en la formación de profesores de biología, física y química, quienes en las etapas finales de su formación inicial diseñan unidades didácticas pensadas para la formación de maestros de primaria y dedicadas a la enseñanza de las geociencias, que luego materializan durante la residencia docente desarrollada en un profesorado de educación primaria de la ciudad de Buenos Aires. Encontramos que tener una idea clara sobre cuáles son los obstáculos principales para el aprendizaje de las cuestiones disciplinares aportaba un fuerte elemento organizador al diseño de la unidad didáctica, al tiempo que le brindaba a nuestros alumnos una puerta de acceso a este cuerpo de conocimientos nuevo. A su vez, resultó potente encontrar en las disciplinas de origen de los alumnos del profesorado elementos de esa formación que sirvieran como puntos de partida en los que anclar los nuevos conceptos del área de las geociencias. Resultó altamente valorado el trabajo de tutoría y acompañamiento que recibieron los alumnos durante todo el trabajo, así como los espacios de discusión y reflexión previos, paralelos y posteriores a la práctica. Esto les permitió enfrentar con buenos resultados el desafío de trabajar dos campos nuevos para ellos: las ciencias de la Tierra y la formación de docentes. Entendemos que el proceso llevado adelante ejemplifica la potencia del valor formador de las instancias de práctica y residencia docente.
How to find the lower altitude of a region using a pair of aerial photography?
Authors: Martins José R. S.
Published: December 2018

Nos dias atuais, os estudantes estão a viver em um mundo repleto de imagens e sentem falta de atividades educativas práticas e lúdicas na escola. A maioria dos currículos escolares não prevê formas de ensino que permitam que os alunos compreendam imagens e reflitam sobre a importância destas. Esse artigo visa mostrar que uma pergunta, formulada por um estudante durante uma atividade prática, pode funcionar como um estopim para deflagrar um processo de construção do conhecimento, cuja base foi um estudo analítico prévio do meio.
PERBEDAAN PENGETAHUAN REMAJA TENTANG SADARI SEBELUM DAN SESUDAH PENYULUHAN KESEHATAN DI SMKN 5 SURABAYA
Authors: Yulinda Arif
Published: December 2018

Kanker payudara merupakan kanker penyebab kematian tertinggi nomor 2 setelah kanker leher rahim. Saat ini, kanker payudara sudah mulai menyerang remaja. Namun remaja masih memiliki pengetahuan yang rendah mengenai kanker payudara dan deteksi dini kanker payudara. Tujuan dari penelitian ini adalah untuk menganalisis perbedaan pengetahuan sebelum dan sesudah penyuluhan kesehatan pada remaja putri di SMKN Negeri 5 Surabaya. Penelitian ini bersifat observational dengan desain cross-sectional dan analitik. Populasi penelitian adalah sebesar 100 orang. Besar sampel ditentukan dengan metode simple random sampling dan diperoleh 80 orang. Data didapatkan melalui penilaian pengetahuan sebelum dan sesudah penyuluhan kesehatan. Hasil penilaian menunjukkan terdapat peningkatan tingkat pengetahuan. Remaja putri dengan tingkat pengetahuan baik meningkat dari 64 orang (80%) menjadi 75 orang (83,75%). Dan tingkat pengetahuan cukup dari 16 orang (20%) menjadi  5 orang (6,25%). Hasil uji statistika dengan menggunakan Wilcoxon Signed Rank Test menunjukkan bahwa nilai p value (0,000) > α (0,05). Artinya bahwa terdapat perbedaan antara pengetahuanvsebelum dan sesudah penyuluhan kesehatan. Disarankan kepada remaja putri untuk melakukan SADARI secara rutin dan sekolah melakukan penyuluhan kesehatan siswanya. Kata kunci: kanker payudara, SADARI, pengetahuan, penyuluhan
Analysis of the Efficiency of Some Methods of Construction of Phylogenetic Trees Used in Evaluation of Microorganisms Evolutionary Relations
Authors: Volkov Yu. P. , Eroshenko G. A.
Published: December 2018

The review presents description of some methods of phylogenetic trees construction used in evaluation of different organisms evolutionary relations. Described are advantages and disadvantages of different groups of methods applicable for dendrograms construction.
Selection and Disinfection of Adsorbents Used for Transportation of Pathogenic Biological Agents
Authors: Malyukova T. A. , Sazanova E. V. , Kostyukova T. A. , Golovko E. M. , Boyko A. V.
Published: December 2018

Evaluated are available materials, having absorbability, in view of using them as adsorbents for transportation of pathogenic biological agents. Worked out is the way of their disinfection
Neuroendocrinal Aspects of Analysis of Biomodel Lymphoid Organs Response to Administration of Live Tularemia Vaccine
Authors: Bugorkova S. A. , Barulina I. S. , Schukovskaya T. N. , Sayapina L. V.
Published: December 2018

Evaluated were alterations in thymus, regional and remote lymphatic glands, and spleen of biomodels as well as neuroendocrinal cells reaction in these organs in simulating anti-tularemia vaccinal process. Received are quantitative characteristics of neuroendocrinal environment state of biomodels' lymphoid organs on the 5 day after administration of anti-tularemia vaccine in different doses. Elucidated were certain principles in cells' reaction of APUD-system of biomodel's lymphoid organs and lungs, associated with nature of their alterations. Identified were the prospects of application of the APUD-system cells quantitative characteristics in view of improving and optimizing the evaluation methods as regards safety and efficiency of live vaccines.
Study of Pathogenic Properties of Brucellosis Agents under Artificial Immunosuppression Conditions
Authors: Shabalin B. A. , Okhapkina V. Yu. , Darmov I. V. , Kuznetsov S. L.
Published: December 2018

The influence of artificial immunodeficiency state upon brucellosis course has been studied experimentally. Trials on laboratory animals demonstrated faster and more intensive progression of infectious process as well as increased frequency of the fatal cases of the disease caused by brucellosis agents.
Comparative Analysis of Diagnostic Plague Antiphage Sera Received from Producers of Different Types
Authors: Alenkina T. V. , Krasichkov G. G. , Fomina G. M. , Lobovikova O. A. , Mironova N. P. , Pudenkova O. S. , Nikiforov A. K. , Sayapina L. V. , Malakhaeva A. N.
Published: December 2018

Manufacturing process of ovine hyperimmune sera against Pokrovskaya plague bacteriophage was worked out. Their stability in the process of storage was studied. Sera received were used as raw material to produce three experimental series of diagnostic plague antiphage ovine dry serum. Physicochemical properties, specific activity and specificity of the developed preparation were evaluated in comparison with similar commercial preparation produced from the equine serum. Similarity of all test parameters was revealed that enabled to recommend diagnostic plague antiphage ovine serum for application.
Eliminación del cáncer de cérvix en América Latina
Authors: Herrero Rolando
Published: December 2018

[Not available]
White-tailed Deer Browsing and Rubbing Preferences for Trees and Shrubs That Produce Nontimber Forest Products
Authors: Hygnstrom Scott E. , Skelton Peter D. , Josiah Scott J. , Gilsdorf Jason M. , Virchow Dallas R. , Brandle James A. , Jayaprakash Anil K. , Eskridge Kent M. , VerCauteren Kurt C.
Published: December 2018

Nontimber forest products (food, herbal medicinals, and woody floral and handicraft products) produced in forest, agroforestry, and horticultural systems can be important sources of income to landowners. White-tailed deer (Odocoileus virginianus) can reduce the quality, quantity, and profitability of forest products by browsing twigs and rubbing stems, resulting in direct and indirect losses to production enterprises. We evaluated deer damage (frequency and intensity of browsing and rubbing) sustained by 26 species of trees and shrubs, the relationships among morphological features of trees and shrubs to damage levels, and the economic impacts of deer damage on the production of nontimber forest products. Levels of browsing were high (frequency >93% and intensity >50%) in most species of trees and shrubs, with the highest intensity (>60%) occurring in chinese chestnut (Castanea mollisima) and dogwood (Cornus spp.), and the lowest (<20%) in ginkgo (Ginkgo biloba), curly willow (Salix matsudana), ‘Scarlet Curls’ curly willow, smooth sumac (Rhus glabra), and pussy willow (Salix caprea). Species of trees or shrubs with one or a few stout stems unprotected by dense branching [e.g., american elderberry (Sambucus canadensis), smooth sumac, and curly willow] sustained the most damage by rubbing. Trees and shrubs with many small diameter stems or with dense tangled branching [e.g. redozier dogwood (Cornus sericea), forsythia (Forsythia suspensa), ‘Flame’ willow (Salix alba), and ‘Streamco’ basket willow (Salix purpurea)] were damaged the least by rubbing. Annual economic costs of deer damage to producers of nontimber forest products can range from $26/acre for pussy willow to $1595/acre for curly willow.
Exploratory Assessment of Consumer Preferences for Chestnut Attributes in Missouri
Authors: Aguilar Francisco X. , Cernusca Mihaela M. , Gold Michael A.
Published: December 2018

This article explores consumers' preferences for different chestnut (Castanea spp.) attributes and studies differences across potential market segments. The study was conducted between 2003 and 2007 during the Missouri Chestnut Roast festival. The festival, held annually in October during the chestnut harvest season, is one of mid-Missouri's premier family-oriented events. A longitudinal study completed among festival visitors in 2003, 2004, and 2006 to identify chestnut characteristics that influence purchasing decisions was complemented with a conjoint analysis in 2007. The conjoint analysis used a conditional logit model to investigate responses from pairwise product profile comparisons. The attributes investigated include chestnut size (small, medium, and large), price ($3, $5, and $7 per pound), production process (organic and conventional), and origin (Missouri, United States, and imported). Results suggest a strong preference for locally and U.S.-grown compared with imported chestnuts. Local growers that provide the market with medium-size chestnuts that carry organic certification could command a market premium compared with imported/nonorganic certified chestnuts.
Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone
Authors: Papinchak Heather L. , Holcomb E. Jay , Best Teodora Orendovici , Decoteau Dennis R.
Published: December 2018

Three common indoor houseplants, snake plant (Sansevieria trifasciata), spider plant (Chlorophytum comosum), and golden pothos (Epipremnum aureum), were evaluated for their species effectiveness in reducing ozone concentrations in a simulated indoor environment. Continuously stirred tank reactor (CSTR) chambers housed within a greenhouse equipped with a charcoal filtration air supply system were used to simulate an indoor environment in which ozone concentrations could be measured and regulated. Ozone was injected into the chambers and when concentrations reached 200 ± 5 ppb, the ozone-generating system was turned off and ozone concentrations over time (ozone was monitored every 5–6 min in each chamber) were recorded until about <5 ppb were measured in the treatment chamber. On average, ozone depletion time (time from when the ozone generating system was turned off at ≈200 ppb to <5 ppb in the chamber) ranged from 38 to 120 min per evaluation. Ozone depletion rates were higher within chambers that contained plants than within control chambers without plants, but there were no plant species differences.
Peel Fluorescence as a Means to Identify Freeze-damaged Navel Oranges
Authors: Obenland David , Margosan Dennis , Collin Sue , Sievert James , Fjeld Kent , Arpaia Mary Lu , Thompson James , Slaughter David
Published: December 2018

The use of ultraviolet fluorescence to identify freeze-damaged navel oranges (Citrus sinensis) was evaluated using fruit harvested following a natural freeze that occurred in California in Jan. 2007. Navel oranges were harvested after the freeze from 14 sites that were previously determined to have a slight to moderate amount of freeze damage. The fruit were evaluated for the presence of small yellow spots characteristic of freeze damage that fluoresce when viewed under a ultraviolet-A (365 nm) source and were then cut and rated using a method currently used by the California Department of Food and Agriculture (CDFA) to determine the presence of internal freeze damage. The percentage of freeze-damaged fruit in each lot as determined by the CDFA method ranged from 0% to 89%. The accuracy of classifying fruit as freeze damaged in each lot by peel fluorescence averaged 44%, with the fruit lots containing the greatest amount of freeze damage having the highest classification percentages. False-positives occurred at a lower rate than false-negatives among the lots. Although some fading was evident, the fluorescence persisted and was readily visible for at least 9 weeks after the freeze event. Removal of fruit with ultraviolet peel fluorescence was ineffective in reducing the percentage of damaged fruit within the examined lots. In the second part of the test, eighteen lots of potentially freeze-damaged fruit were obtained from a packing house, immediately evaluated for freeze damage using ultraviolet light, and then after 4 weeks of storage, were evaluated again using the CDFA method. Fruit that had a slight to moderate degree of freeze damage were tasted and evaluated for sensory characteristics. Both methods of freeze damage detection were poorly related to the sensory characteristics.
A Comparison of Rapid Potentiometric and Colorimetric Methods for Measuring Tissue Nitrate Concentrations in Leafy Green Vegetables
Authors: Ott-Borrelli Kristy A. , Koenig Richard T. , Miles Carol A.
Published: December 2018

Leafy green vegetables such as lettuce (Lactuca sativa), Asian greens (Brassica spp.) and spinach (Spinacia oleracea) have a tendency to accumulate high concentrations of potentially harmful nitrate–nitrogen (NO3-N). It would be advantageous for growers to have rapid and inexpensive methods to accurately measure plant tissue NO3-N to make fertility and harvest management decisions for these crops. This study compared fresh sap expressed from whole leaves and analyzed with a Cardy meter with the analysis of dry leaf tissue extracts analyzed with a benchtop ion selective electrode (ISE) and an automated colorimetric method for determining NO3-N concentration. Results from ISE and colorimetric analysis of the same dry leaf tissue extracts had a strong relationship (r2 = 0.92). The ISE was relatively easy to operate and affordable, suggesting it is an adequate substitute for automated colorimetric analysis of dry plant tissue extracts. Results of fresh whole leaf sap analyzed with the Cardy meter showed a poor relationship with dry leaf tissue extracted and analyzed using the ISE (r2 = 0.25) or with colorimetric analysis (r2 = 0.21). When fresh whole leaf sap was diluted 1:1 with aluminum sulfate [Al2(SO4)3] to adjust for potential matrix effects, there was still a relatively poor relationship (r2 = 0.41) between the diluted sap samples analyzed with a Cardy meter and the dry leaf tissue extracted and analyzed with the ISE. When the same dry leaf tissue extracts were analyzed with the Cardy meter and the ISE, the results related well (r2 = 0.96). As a result of tissue processing and/or instrument differences, Cardy meter analysis of sap expressed from whole leaves was not comparable to ISE or colorimetric analyses of dry leaf tissue extracts for leafy green vegetables.