bluuebunny/crossref_metadata_2025 huggingface dataset:
Potensi Senyawa Salisilanilida Dari Minyak Gandapura Sebagai Antiinflamasi dan Analgetik Secara In Vivo
Authors: Adhityasmara Dhimas , Hanhadyanaputri Eka Susanti , Indriyanti Erwin
Published: August 2024

Administration of non-steroidal anti-inflammatory drugs (NSAIDs) is the first therapeutic choice for the treatment of pain and inflammation. Several existing amide derivatives show their properties as anti-inflammatory, antidegenerative, anticancer, antimicrobial and analgesic, one of which is salicylanilide. The precursor for salicylanilide synthesis is carboxylic acid, using natural methyl salicylate from gondopuro oil and amines sonochemically with the help of Decyclocarbodiimide (DCC) coupling reagent. The research aims to carry out the synthesis of amide derivatives using DCC coupling reagent with the sonochemical method in 7 hours. Identification of synthetic compounds by spectrum elucidation using infrared spectrophotometry (FTIR-ATR), GC-MS and in-vivo anti-inflammatory and analgesic activity tests. In this study, the mixture was sonicated for 7Â hours at a temperature of Â±0oC, then left in the refrigerator overnight, evaporated at a temperature of 65oC. The precipitate formed was filtered using Buchner, washed using cold distilled water and washed again using methanol. The crystals obtained were then dried in an oven at 40ÂºC until dry, then the % yield of the synthesized compound was determined. Tests include organoleptic tests, melting point, solubility, FTIR, GC-MS In vivo anti-inflammatory and analgesic activity tests. The research results showed that salicylanilide compounds could be synthesized in 7 hours with a % yield of 27.55%. The resulting synthesis can melt from a temperature of 218-222Â°C and can dissolve in methanol, ethanol, chloroform and ether but does not dissolve in distilled water. FTIR testing on salicylanilide compounds showed the presence of phenolic -OH, aromatic C-H, C=O amide and aromatic C=C groups. The synthesized compound produced an abundance of 2.43%. The highest percentage of anti-inflammatory power was at dose 3 synthesis (7.56 mg/ 200 grams of rat body weight) at 44.46% and the highest analgesic effect was at dose 4 synthesis (10.08 mg/ 200 grams Rat BW)
Aktivitas Antiasma Nigella sativa L. Dan Amomum cardamomum Terhadap Otot Polos Bronkus, Epitel Bronkiolus, Jumlah Sel Mast, Eosinophil Mencit Asma
Authors: Firmansyah Gunawan , Widodo Gunawan Pamudji , Wijayanti Tri
Published: August 2024

Asthma is a chronic respiratory inflammation that limits expiratory air flow. Black cumin reduces the infiltration of inflammatory cells in the respiratory tract comparable to class III antihistamines, cardamom suppresses the formation of a Th2 immune response and has the potential to be therapeutic for allergic asthma. This study aims to determine the profile of black cumin & cardamom essential oils using GC-MS, the effect of the combination of black cumin & cardamom in reducing the thickness of bronchial smooth muscle, bronchiolar epithelium, number of mast cells, and eosinophils in asthmatic mice. This research is an experimental Post-test Only Control Group Design, creating an OVA-induced asthma test animal model of 30 Balb/C mice divided into 6 normal groups (N), asthma control (N-), positive control (P+) and 3 treatment groups with dose variations (K1, K2, K3). Day 7 desensitization OVA 10Î¼g+1 mg Al(OH)3 0.5mL NaCl intraperitoneally, day 14 re-desensitization OVA 20Î¼g+2 mg Al(OH)3 1 mL NaCl. On the 21st, 23rd and 25th days, 1% OVA was inhaled. Days 26 to 39 (K1), (K2), (K3) were given a combination of black cumin oil &Â cardamom. On the 40th day, histopathology was terminated. The results of the study showed that in 3 groups of dose variations with (P+) the thickness of bronchial smooth muscle, bronchiolar epithelium, mast cells and eosinophils was significantly greater (p>0.05), meaning that there was no statistically significant difference as an anti-asthma, the combination of black cumin & cardamom was proven. reducing the thickness of bronchial smooth muscle, bronchiolar epithelium, number of mast cells and eosinophils in asthmatic mice with optimal doses of a combination of black cumin oil and cardamom oil in a ratio of 75:25 (K2) showed better antiasthmatic potential, compared to K1 (50:50) and K3 (25 :75).
Aktivitas Antijamur Fraksi N-Heksana Kulit Buah Citrus sinensis (L.) Osbeck
Authors: Octaviani Melzi , Suryani Wiwin , Sandi Nofri Hendri
Published: August 2024

The sweet orange (Citrus sinensis (L.) Osbeck) is a fruit that is loved by all walks of life because of its sweet taste. The flesh part of the fruit is consumed, while the fruit peel is discarded. However, the fruit peel also contains secondary metabolites, which have various biological activities. The peel of this sweet orange fruit contains secondary metabolites of alkaloids, flavonoids, phenolics, steroids, and terpenoids. This study aims to determine the antifungal activity of the n-hexane fraction against Trichophyton mentagrophytes and Candida albicans using the disc diffusion method and the Minimum Inhibitory Concentration (MIC). The results of measuring the diameter of the inhibition zone formed on the fungus Trichophyton mentagrophytes at a concentration of 50; 25; 12.5; 6.25; 3.125 and 1.5625% w/v, respectively 12.29Â±0.08; 11.14Â±0.12; 9.54Â±0.17; 7.01Â±0.12; 6.19Â±0.03; 6.06 Â± 0.03 mm, with a MIC of 1.5625 %. Results of measuring the diameter of the inhibition zone formed against Candida albicans fungi respectively 9.97 Â± 0.02; 9.05Â±0.18; 8.32Â±0.38; 7.09Â±0.07; 6.00Â±0.00; 6.00Â±0.00 mm, with a MIC of 6.25%. The results of data analysis using one-way ANOVA statistics showed that there was a significant difference (p<0.05) between variations in the concentration of the test fraction with positive control and negative control. Based on the research that has been carried out, it can be concluded that the n-hexane fraction of sweet orange peel has activity in inhibiting the growth of the test fungus, with the best antibacterial activity at a concentration of 50% w/v.
A Vector Nanoplatform for the Bioimaging of Deep-Seated Tumors
Authors: Shramova E. I. , Deyev S. M. , Proshkina G. M.
Published: August 2024

Today, in preclinical studies, optical bioimaging based on luminescence and fluorescence is indispensable in studying the development of neoplastic transformations, the proliferative activity of the tumor, its metastatic potential, as well as the therapeutic effect of antitumor agents. In order to expand the capabilities of optical imaging, sensors based on the bioluminescence resonance energy transfer (BRET) mechanism and, therefore, independent of an external light source are being developed. A targeted nanoplatform based on HER2-specific liposomes whose internal environment contains a genetically encoded BRET sensor was developed in this study to visualize deep-seated tumors characterized by overexpression of human epidermal growth factor receptor type 2 (HER2). The BRET sensor is a hybrid protein consisting of the highly catalytic luciferase NanoLuc (an energy donor) and a LSSmKate1 red fluorescent protein with a large Stokes shift (an energy acceptor). During the bioimaging of disseminated intraperitoneal tumors formed by HER2-positive SKOV3.ip1cells of serous ovarian cystadenocarcinoma, it was shown that the developed system is applicable in detecting deep-seated tumors of a certain molecular profile. The developed system can become an efficient platform for optimizing preclinical studies of novel targeted drugs.
The integrated programs in medical education: modern trends and development prospects
Authors:   N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia, Snegireva Yu.Yu. , Gurtskoy L.D. ,   N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia,   The Federal State Budget Educational Institution of Higher Education “The Rostov State Medical University”, 344022, Rostov-on-Don, Russia, Tsoriev A.E. ,   The State Autonomous Health Care Institution of the Sverdlovsk Oblast “Thew Sverdlovsk Oblast Clinical Hospital”, 620102, Yekaterinburg, Russia
Published: August 2024

The article considers possibilities of forming integrated educational programs of personnel training. The integration supposes interdisciplinary approach and inclusion within curricula, besides medical subjects, disciplines from different fields of science. As practice demonstrates, this approach provides larger spectrum of professional knowledge, skills and competencies and contributes into better career guidance and subsequent employment of graduates.
SISTEM INFORMASI PERPUSTAKAAN BERBASIS WEB MENGGUNAKAN LARAVEL 10 DI UNIVERSITAS HINDU INDONESIA
Authors: Soekmawati Ni Ketut , Adi Wardana I Putu Mahendra , Asmarajaya I Kadek Andy
Published: August 2024

Sistem informasi merupakan hal yang sangat penting bagi perkembangan teknologi di era saat ini. Sistem akan membantu instansi untuk mengelola informasi dengan lebih efesien, seperti halnya perpustakaan dapat dibuat secara online agar mudah diakses. Perpustakaan di Universitas Hindu Indonesia masih menggunakan sistem yang manual dimana belum memiliki sistem yang online untuk dapat diakses oleh siapapun jadi masih sulit untuk melihat buku yang dimiliki perpustakaan Universitas Hindu Indonesia. Hal tersebut menyebabkan peneliti ingin membuat sebuah sistem informasi perpustakaan berbasis web yang nantinya sistem perpustakaan ini akan dapat diakses darimanapun dan kapanpun. Sistem ini akan dikembangkan menggunakan waterfall model karena prosesnya yang terstruktur dan sistematis dimana akan dimulai dari tahapan yang berurut yaitu requirements, design, implementation, testing dan maintenance. Pengumpulan informasi sebagai data pengembangan sistem akan menggunakan Teknik pengumpulan data primer dan sekunder seperti observasi, wawancara, studi kepustakaan dan dokumentasi. Sebelum sistem diimplementasikan perlu dibuatkan rancangan alur sistem yang mana akan menggunakan use case diagram, activity diagram, entitiy relationship diagram (ERD) dan data flow diagram (DFD). Selanjutnya sistem akan dilakukan implementasi menggunakan aplikasi visual studio code dengan framework Laravel 10 dan PHP 8.2. Setelah sistem diimplementasikan selanjutnya sistem akan dilakukan pengujian menggunakan blackbox testing untuk menguji masukan dan keluaran dari sistem. Hasil pengujian menyatakan bahwa sistem perpustakaan tidak terdapat error dan bug. Diharapkan sistem informasi perpustakaan berbasis web ini dapat membantu pihak perpustakaan menyebarkan informasi literasi dan meningkatkan intelektual nantinya.
GÂY TÊ THẦN KINH NGOẠI VI CHO PHẪU THUẬT KẾT HỢP XƯƠNG CẲNG CHÂN Ở NGƯỜI BỆNH SUY TIM NẶNG: BÁO CÁO CA LÂM SÀNG
Authors: Nguyễn Thị Ngọc Đào , Trần Thành Phát , Nguyễn Thành Sang
Published: August 2024

Đặt vấn đề: Gây mê hồi sức cho phẫu thuật trên người bệnh suy tim phân suất tống máu giảm nặng có nhiều nguy cơ và thách thức đối với bác sĩ gây mê hồi sức. Chúng tôi báo cáo trường hợp gây tê thần kinh ngoại vi cho phẫu thuật kết hợp xương cẳng chân ở người bệnh suy tim EF 27%.

Ca lâm sàng: Người bệnh nam 75 nhập cấp cứu sau tai nạn giao thông được chẩn đoán gãy 1/3 dưới hai xương cẳng chân phải. Người bệnh có bệnh nền gồm suy tim mạn EF 27% do bệnh mạch vành đã đặt stent. Người bệnh được lên chương trình phẫu thuật kết hợp xương gãy 1/3 dưới xương chày phải bằng nẹp vít và đặt nẹp vít khóa mắt cá ngoài chân phải. Người bệnh được gây tê thần kinh tọa vùng khoeo và thần kinh đùi để phẫu thuật. Thời gian phẫu thuật 2 giờ 30 phút, trong suốt quá trình phẫu thuật người bệnh tỉnh, sinh hiệu ổn.

Kết luận: Phẫu thuật vùng cẳng chân có thể thực hiện dưới gây tê thần kinh ngoại vi. Đây là phương pháp vô cảm an toàn và không gây ảnh hưởng huyết động do đó thích hợp với những người bệnh nguy cơ cao như suy tim…

Từ khóa: gây tê thần kinh tọa, gây tê thần kinh đùi, kết hợp xương chày, suy tim EF giảm
Impacts of Physiological Stress on Arab Simultaneous Interpreters
Authors: Almahasees Zakaryia , Abu-Rayyash Hussein
Published: August 2024

The study aimed to examine the substantial impact of stress on Arab simultaneous interpreters. The study designed a survey of two main constructs. The first construct aimed at identifying demographic information, while the second construct gathered information about stress assessment, physiological reactions to stress, and management mechanisms. The survey was shared with Arab simultaneous interpreters via the most common social networking sites: Facebook, LinkedIn, and Twitter. The study found that 50% of the respondents indicated having stress while doing their interpreting tasks. The study revealed that stress leads to a surge in heart rate, headaches, and muscle cramps. More importantly, the physiological symptoms impeded interpreters' cognitive performance. Therefore, interpreters could not focus and retrieve information properly, which inhibited the spoken message's accuracy and comprehension. For cognitive performance, the study showed that stress inhibits the quality of interpretation, which results in producing incomplete interpretation.
Razones que conducen al abandono de la lactancia materna en américa latina: una revisión integrativa
Authors: Torres Guevara Andrés Camilo , Hinestroza Rentería María Ximena , Echeverri Hernández Verónica , Bernal Ordoñez Lina Karina
Published: August 2024

Metodología: se realizó una revisión integradora de la literatura en noviembre de 2022. Para la búsqueda de artículos se utilizaron las siguientes bases de datos en línea: Scielo, Redalyc y Bdenf, mediante los términos de búsqueda lactancia materna y destete y cuyo idioma fuera español, inglés o portugués. Resultados: los principales motivos de abandono de la lactancia están relacionados con factores socio culturales influidos por los conocimientos que tenían sobre el tema, así como la mala técnica utilizada al amamantar. Conclusiones: es necesario continuar investigando sobre este tema para comprender mejor el contexto en el que se manifiestan los factores que conducen al abandono de la lactancia materna durante el primer año de vida del bebé, con el fin de mejorar las condiciones y determinantes del pro ceso de lactancia materna, así como la salud de los bebés y las madres lactantes de todo el mundo
Estrategias para el desarrollo de emprendimientos en el municipio de Sutatausa
Authors: Gutiérrez Arango Wilmer de Jesús , Pacheco Martínez Yefris José , Duque Cruz Oscar Yamith
Published: August 2024

Este estudio trata de la necesidad de desarrollar estrategias para que los jóvenes del municipio de Sutatausa pudieran adquirir conocimientos en la creación y formulación de proyectos de emprendimientos o creación de empresas. Este municipio es altamente minero y su economía se basa en la minería, la agricultura y la artesanía. La investigación se ejecutó basándose en informes de órganos de control gubernamentales, como la alcaldía del municipio y el DANE, junto a otras muestras de información; se identifican los factores influyentes, como la falta de oportunidades laborales, de formación profesional, la ausencia de instituciones académicas que faciliten el ingreso de los jóvenes y la falta de ingresos económicos. Finalmente, se pudo conocer que uno de los pilares fundamentales que tiene el municipio para brindar nuevas oportunidades de empleabilidad es el sector del turismo, dado que Sutatausa cuenta con atractivos turísticos culturales muy importantes y un hermoso paisaje
The compact circumstellar material of SN 2024ggi: another supernova with a pre-explosion effervescent zone and jet-driven explosion
Authors: Soker Noam
Published: August 2024

I examine recent theoretical studies and observations of the recent core-collapse supernova (CCSN) SN~20224ggi and find that the likely explanation for its dense, compact circumstellar material is an effervescent model, where parcels or streams of gas are uplifted by stellar convection and pulsation and fall back. The effervescent zone exists alongside the regular wind from the red supergiant (RSG) progenitor of SN~2024ggi. I find that an extended wind-acceleration zone encounters some difficulties in accounting for the required CSM mass. Recent modelling finds the explosion energy of SN~2024ggi to be erg, and up to erg. I examine this explosion energy against a recent study of the delayed neutrino explosion mechanism and find that this mechanism might have some difficulties in accounting for the required energy. This might suggest that the explosion was caused by the jittering jets explosion mechanism (JJEM). This adds to other recent pieces of evidence supporting the JJEM, particularly point-symmetric CCSN remnants.
External Debt Pass-through to Inflation in Nigeria
Authors: Asue Emmanuel , Ikyaator James
Published: August 2024

This study examines external debt pass-through to inflation in Nigeria using annual data from 1981 to 2020 based on structural vector autoregressive (SVAR) model. The results reveal that an increase in external debt service leads to a significant depreciation of the exchange rate, which leads to a contemporaneous increase in inflation, while the direct response of inflation to external debt is statistically not significant. The impulse response confirms these results. The forecast error variance decomposition depicts that future values of official exchange rate depend on external debt, inflation and external debt service. The study recommends that the Nigerian government should curtail its acquisition of external loans as much as possible and widen the tax net to ensure that all taxable citizens obey their tax obligations.
Drivers’ Knowledge, Attitude and Practices Towards Traffic Rules and Regulations
Authors: Abbas Sheer , Fatima Sidra , Sharif Azhar , Ramzan Kasuri Muhamman
Published: August 2024

Research frequently reports that the majority of crashes (up to 80%), are the fault of drivers. Further, the WHO reports that most fatal crashes occur in low- and middle-income countries (LMIC). In LMIC, including Pakistan, most drivers have low levels of knowledge about traffic rules and regulations, have negative attitudes towards rules and regulations and often violate road safety rules. This study used a structured survey of drivers in Karachi, Pakistan (n=260). Most respondents were aware that helmet use for motorbike riders is compulsory (74.6%), agreed it was important to follow road signs (74.2%) and wear a seat belt (64.6%). However, over half did not know the speed limit in residential areas (54.6%) and almost half considered drug use when driving was not dangerous or were against the penalty or fine for violation of traffic laws (45.4%). In addition, 45.8% of all drivers thought driving licenses were unnecessary. This study suggests there may be low levels of driver knowledge of certain road rules (e.g. speed limit), negative attitudes about certain safe driving practices (drug driving), and low levels of value placed on driving license in Karachi, Pakistan. Analysis suggest that knowledge and attitude affect driver practices in Karachi, Pakistan. Strengthening enforcement and related public communication measures about traffic rules and greater penalties that are sufficiently deterring for the violators of the traffic rules is needed. There must also be a formal mechanism to issue the driving licence after a proper test of the knowledge of road rules and driving following those rules.
Role of Culture, Income Level and Governance Quality on Driver Behaviours
Authors: Arslan Burcu , Özkan Türker
Published: August 2024

The regional differences in road safety parameters have been attributed to cultural and economic factors. Nevertheless, there are differences in road safety outcomes between countries with similar cultural backgrounds and income levels. The current study examines this fact by considering the role of governance quality in the relationship between culture, income level, and driver behaviours. In this study, we modelled driver behaviour scores from 65 countries with Hofstede’s cultural dimensions, Schwartz’s cultural values, and the worldwide governance indicators from the World Bank’s database. Hayes’ PROCESS macro was utilised to analyse the moderation roles of governance quality and income level in the relationship between culture and driver behaviours. High governance quality can prevent or discourage drivers to commit non-speeding violations. Governance quality could regulate the relationship between cultural variables, income level, and driver behaviours. The Power Distance dimension was associated with non-speeding violations in high-income countries with medium or low governance quality. The embeddedness value was associated with speeding behaviours in countries with low governance quality and high/medium income. Governance quality is a critical factor of road safety in high- and middle-income countries. Where there is a lack of qualified governance to establish and enforce rules and individuals have access to social and material power, the culture becomes the determinant of aberrant driver behaviours. This is the first study relating governance quality to driver behaviours at the country level. The implications and limitations of the study were acknowledged.
Retrospective comparison of thyroid hormones in Steller sea lions Eumetopias jubatus under professional care with and without thyroid disease
Authors: Lum AM , Weisbrod TC , Jacob SI , Isaza R , Goertz CEC , Tuttle AD , Deegan TC , Francis-Floyd R , Stacy NI
Published: August 2024

An evaluation of morbidity and mortality in Steller sea lions (SSLs) Eumetopias jubatus under professional care identified a high prevalence of thyroid disease in aged animals. While studies have investigated the effects of age, season, nutrition, stressors, and pollutants on thyroid hormones in pinnipeds, data from individuals with known thyroid disease are lacking. Histopathological reports of adult SSLs in North American aquariums from 1979 to 2022 with banked serum (n = 14) were reviewed. Radioimmunoassays, which have been validated in this species, were used to determine triiodothyronine (TT3), total thyroxine (TT4), and free thyroxine (fT4). A solid-phase chemiluminescent immunometric assay for thyroid-stimulating hormone (TSH) quantification was validated by testing inter- and intra-assay repeatability, recovery, and parallelism. Lesions included follicular cysts (n = 5), adenoma with thyroglossal duct or follicular cysts (n = 2), medullary or follicular C-cell carcinoma with follicular cysts and nodular hyperplasia (n = 1), neuroendocrine carcinoma with follicular cysts (n = 1), and sarcomatoid carcinoma metastasis to the thyroid (n = 1). Significantly lower concentrations of TT3, TT4, and fT4 in SSLs with thyroid disease (n = 10) versus those without (n = 4) were attributed to space-occupying lesions, advanced age, and/or season. TSH was not significantly different between groups. Fifty percent of diseased SSL profiles were within reference ranges, and all individuals with lesions were clinically euthyroid. These data expand the current understanding of thyroid disease in SSLs and underscore the need for additional diagnostics (e.g. cervical ultrasound) concurrently with hormone assays to effectively screen for underlying abnormalities.
Microhabitat selection by François’ langur Trachypithecus francoisi in Mayanghe National Nature Reserve, China
Authors: Han J , Zou Q , Dong B
Published: August 2024

Understanding microhabitat use and selection by terrestrial animals and their driving factors is one of the major tasks in ecology and conservation biology. Many habitat selection studies do not differentiate habitat characteristics between core (the key protection area of a national nature reserve) and non-core (the buffer zone and experimental zone of the reserve) areas, relying instead on presence/absence data. In this study, we compared microhabitat characteristics between core and non-core areas of François’ langur Trachypithecus francoisi in the Mayanghe National Nature Reserve, southwestern China. Using a resource selection function (RSF), we systematically surveyed 20 transects, establishing 228 tree quadrats (162 in the core area and 66 in the non-core area). The collected data included topographic, anthropogenic, and vegetation-related variables. The results indicate that quadrats in core areas had higher elevations and greater distances from roads, rivers, settlements, and agricultural land compared to those in non-core areas. Moreover, we found that elevation, distance to rivers, distance to roads, tree quantity, and tree diameter at breast height are key factors driving microhabitat selection by François’ langur. The findings highlight the importance of prioritizing high-elevation areas that are far from roads to improve habitat management and restoration for this species. This study enhances our understanding of habitat selection and contributes to current population conservation efforts.
Research on Experimental Hypertension in Prague (1966-2009)
Authors: Kuneš J , Zicha J
Published: August 2024

The study of ontogenetic aspects of water and electrolyte metabolism performed in the Institute of Physiology (Czechoslovak Academy of Sciences) led to the research on the increased susceptibility of immature rats to salt-dependent forms of hypertension since 1966. Hemodynamic studies in developing rats paved the way to the evaluation of hemodynamic mechanisms during the development of genetic hypertension in SHR. A particular attention was focused on altered renal function and kidney damage in both salt and genetic hypertension with a special respect to renin-angiotensin system. Renal damage associated with hypertension progression was in the center of interest of several research groups in Prague. The alterations in ion transport, cell calcium handling and membrane structure as well as their relationship to abnormal lipid metabolism were studied in a close cooperation with laboratories in Munich, Glasgow, Montreal and Paris. The role of NO and oxidative stress in various forms of hypertension was a subject of a joint research with our Slovak colleagues focused mainly on NO-deficient hypertension elicited by chronic L-NAME administration. Finally, we adopted a method enabling us to evaluate the balance of vasoconstrictor and vasodilator mechanisms in BP maintenance. Using this method we demonstrated sympathetic hyperactivity and relative NO deficiency in rats with either salt-dependent or genetic hypertension. At the end of the first decennium of this century we were ready to modify our traditional approach towards modern trends in the research of experimental hypertension.
Analysis of Associative Meaning in The Mini Album Song Kalah Bertaruh by Nadin Amizah
Authors: Yuyun Setiawati  , Udjang Pairin M.Basir
Published: August 2024

The rapid development of language not only has an impact on its use but also has an impact on changes in the meaning of words. Therefore, currently changes in meaning appear in various types, one of which is associative meaning. Associative meaning is defined as the meaning of a word that correlates with the context outside the language. Associative meaning consists of connotative meaning, stylistic meaning, effective meaning, collocative meaning and reflective meaning. This research aims to reveal whether or not there is associative meaning in the songs contained in the mini album lose bets by Nadin Amizah, this is also the research data used in this research using documentation type data collection techniques as well as reading and note taking. The results of the analysis concluded that the mini album losing bets by Nadin Amizah contained 23 data with associative meanings. The types of associative meaning include 9 data containing connotative meaning which is also interpreted as figurative meaning, 3 data containing collocative meaning because they relate to a word that was born from another word in the same context, 6 data containing stylisti meaning because they relate to the style of word choice. or social differences, 1 data contains a reflective meaning because it causes an automatic reaction so that it forms another meaning and the last is an effective meaning of 1 data because it reflects emotions related to something that is heard or discussed. The researcher then described these data using qualitative descriptive research.
The Shift of Javanese Language Krama in The Bilingual Community
Authors: Alfarobby Mufti , Agusniar Dian Savitri  , Kisyani Laksono
Published: August 2024

Language contact in social interaction in bilingual communities in Trenggalek district, especially in Miri hamlet, Mlinjon village, is an interesting phenomenon to be studied from a sociolinguistic perspective. Miri Hamlet is one of the areas in Trenggalek Regency with a remote geographical location category. The majority of the Miri hamlet community are bilingual people who master Javanese and Indonesian as a means of communication. This study uses a survey method with a quantitative approach. The source of data in this study is the local community and the data selected is a form of language variation that has undergone a shift. This phenomenon has a correlation not only with aspects of language, but also with socio-cultural aspects. This study aims to describe 1) the form of Javanese language shift in the family domain and 2) the influence of socio-cultural factors on the Javanese language shift in Miri hamlet. The results of this study indicate that (1) there is a shift in the use of the Javanese Krama language in communication between families in Miri hamlet (2) the factors causing the language shift include the influence of social media and the level of public awareness of the preservation of Javanese culture.
The Influence of The Relay Writing Method Assisted With Audio Visual Media on Procedure Text Writing Skills in Class VII Students at SMP Negeri 35 Palembang
Authors: ST. Fianda Kirana  , Dessy Wardiah  , Muhammad Ali
Published: August 2024

This research aims to determine the effect of the relay writing method assisted by audio-visual media on procedural text writing skills in class VII students at Palembang Public Junior School 35.. This type of research is quantitative research that uses simple linear regression testing and multiple linear regression testing to answer the hypothesis in the research. The subjects in this research were class VII.3 as an experimental class with a total of 31 students and class VII.4 as a control class with a total of 33 students. Data collection techniques in this research used documentation and test techniques. Based on the results of testing the first hypothesis, it was found that there was an influence of the application of the relay writing method on the ability to write procedural texts which received a significant value of 0.000. The results of testing the second hypothesis show that there is an influence of the use of audio-visual media on the ability to write procedural texts which gets a significant value of 0.000. The results of testing the third hypothesis prove that there is an influence of applying the relay writing method with the help of the use of audio-visual media on procedural text writing skills which obtained a significant value of 0.000.
Keywords  :  Estafet Writing, Audio Visual, Procedure Text.
Improving Poetry Appreciation Ability Through Demonstration Methods in Indonesian Language Students
Authors: Cahyo Prawoto Eko , Pana Pramulia  , Nur Rohmah
Published: August 2024

Literature teaching has a very important role in providing knowledge about life and fostering emotional sensitivity in students. Therefore, to create literature teaching that is in line with its objectives, Indonesian language teachers are needed who have adequate competence in appreciating literary works. This can be done through the presentation of literary learning in lecture rooms. However, in reality there are problems faced by students in appreciating poetry. For this reason, further efforts are needed to overcome this problem by applying demonstration methods. This research focuses on efforts to increase students' ability to appreciate poetry through demonstration methods. The research method used in this research is a descriptive qualitative method with an experimental approach. The subjects of this research were 24 class A students of the Indonesian Language Education study program class A. The result of the research carried out is the implementation of the demonstration method as an effort to increase student competence in appreciating poetry that works well, as well as achieving learning objectives. Because there was an increase in the average score obtained by students from 2.75 to 4.26 which is included in the good category.
Os impactos das emoções na aprendizagem: interfaces com o ensino de Ciências
Authors: Ribeiro de Lima Jairo , Barros de Lima José Ricardo , Lima Vasconcelos Francisco Herbert , De  Vasconcelos Silva Maria Goretti
Published: August 2024

No contexto do Ensino de Ciências, a escassa bagagem didática na formação inicial do professor tem levado ao ato pedagógico a valorização dos aspectos cognitivos em detrimento da dimensão emocional. Diante disso, o objetivo deste artigo é propor uma reflexão acerca dos impactos das emoções no ensino e na aprendizagem de ciências em interface com as percepções de professores da área de Ciências da Natureza, tendo como suporte teórico as ideias de Henri Wallon. O estudo ancora-se nos pressupostos da pesquisa de métodos mistos. O instrumento para coleta de dados foi o questionário aplicado por meio da ferramenta Google Forms a 22 professores de Biologia, Física e Química que atuam no Ensino Médio. A técnica de análise e interpretação dos dados fundamentou-se na análise temática. Os resultados apontaram para a necessidade de incluir a dimensão emocional no processo ensino-aprendizagem na formação docente, notadamente no campo do Ensino de Ciências, a fim de nortear e fortalecer a indissociabilidade dos aspectos afetivos e cognitivos na prática educativa. Nessa perspectiva, este estudo pode contribuir com os debates que destacam o papel central e decisivo das emoções como fator no processo de aquisição do conhecimento.
Mapeamento bibliográfico dos estudos sobre letramento financeiro no Brasil e no mundo
Authors: Frozza Mateus , Dalla Porta Leonardo , Alves Marcos Alexandre
Published: August 2024

O presente artigo apresenta os resultados de uma investigação acerva das principais produções científicas que abordam a temática envolvendo o letramento financeiro. Trata-se de uma pesquisa bibliográfica, cuja delimitação teórica ocorreu em torno de 17 publicações disponíveis em bancos de dados, como o Catálogo de Teses e Dissertações (CAPES), Biblioteca Digital Brasileira de Teses e Dissertações, e na Associação Nacional de Pós-Graduação e Pesquisa em Administração (ANPAD). Nesse caso, adotamos como critério, quatro eixos que sustentam a presente pesquisa, são eles: Educação Financeira, Letramento Financeiro, Aprendizagem Significativa e Matemática Financeira. Optou-se por trabalhos realizados entre os anos de 2010 a 2020, sendo que alguns trabalhos foram selecionados por conterem aspectos de relevância análogos à nossa pesquisa. Destaca-se que os referencias pesquisados demostraram as contribuições da temática, para a consolidação do conhecimento.
Educação de surdos: glossários de sinais-termo em Libras e a formação de professores bilíngues
Authors: Felix Silva Erliandro , Poletto Sonza Andréa , Martins da Rocha Luiz Renato , Aparecida Diniz Gomides Paula
Published: August 2024

O presente ensaio objetiva contextualizar algumas considerações sobre a construção de glossários de sinais-termos em Libras para a Educação Bilíngue de Surdos. Relacionamos as categorias ‘cultura’, ‘identidade’, ‘inclusão’, ‘acessibilidade’, ‘formação de professores’, ‘educação de surdos’ e ‘bilinguismo’, para indicar a configuração de novas oportunidades para o (re)conhecimento linguístico e identitário da comunidade surda. Esse reconhecimento foi potencializado pela Educação Bilíngue, sobretudo, a partir da publicação da Lei nº 14.191/2021. Indicamos as contribuições de autores como: Albres e Neves (2012), Oliveira (2015), Felten (2016), D’Azevedo (2019), Friedrich (2019), dentre outros. Dialogamos sobre a seguinte questão: quais os benefícios da construção de glossários em Libras para a Educação de Surdos e a formação de professores bilíngues? Nossa hipótese é a de que a construção de glossários de termos em Libras-língua portuguesa potencializa a formação de estudantes surdos, tradutores e intérpretes de Libras e professores bilíngues. A partir dos aspectos debatidos, indicamos que as legislações que abarcam o reconhecimento da surdez, sob o ponto de vista cultural e orientam a Educação de Surdos em nosso país, têm orientado a construção de políticas linguísticas atreladas ao bilinguismo, repercutindo na formação de professores e na expansão da língua em um cenário pluricultural.
Importância das ações educativas do Projeto Cetáceos da Costa Branca no nordeste do Brasil
Authors: Santana Vinícius Gabriel da Silva , Almeida Gavilan Simone , Fernandes Florêncio de Araújo Magnólia
Published: August 2024

Conservar a fauna marinha perpassa por ações educativas em comunidades. Objetivou-se caracterizar as ações do Projeto Cetáceos da Costa Branca da Universidade do Estado do Rio Grande do Norte, no Brasil. Seus membros foram entrevistados sobre sua formação e experiências educacionais e elaboração e execução das ações. Os resultados mostraram que as ações foram executadas em todo o litoral potiguar, sob metodologias voltadas ao público majoritariamente infantojuvenil. Concluímos que as ações buscam proporcionar a sensibilização e mais consciência de comunidades litorâneas sobre a importância ambiental da fauna marinha, reconhecendo seu potencial em prol da conservação.
Efeito da ambidestria organizacional no desempenho da internacionalização das instituições de ensino superior
Authors: Forte Sérgio H A C , Jucá Jane Mary Monteiro , Santos Gizelle Braga dos , Miranda Régis Paiva Alencar , Souza Júnior José de , Pompeu Randal Martins
Published: August 2024

O fenômeno da internacionalização das Instituições de Ensino Superior – IES está em expansão, principalmente depois da Internationalization at Home – IaH, da Internationalization of the Curriculum – IoC e da premência do desenvolvimento da capacidade de inovação das IESs para se diferenciarem e se expandirem. Nesse contexto, esta pesquisa objetiva entender o efeito da ambidestria organizacional no desempenho da internacionalização das instituições de ensino superior. Esta abordagem desenvolve e defende a relação entre os construtos mediante a revisão da literatura existente. O entrelaçamento entre a capacidade de inovação (ambidestria organizacional) e o desempenho de internacionalização é evidente e perceptível à existência de uma proporção de que quanto mais ambidestra for uma organização, maior o desempenho de internacionalização. O modelo conceitual investiga os construtos: a ambidestria organizacional (exploration e exploitation) e o desempenho da internacionalização das IESs (ensino e pesquisa), estruturados em um modelo conceitual, interligados por meio de proposição teórica.
Effect of controlled release of HGF on extracellular vesicle secretion by urine-derived stem cells
Authors: Alwan Abdelrahman , Khalil Fatma , Bowlby Joshua , Peko Gabrielle , Estrada Exel Valle , Singh Sangeeta , Deep Gagan , Zhang Yuanyuan , Farney Alan C. , Opara Emmanuel C.
Published: August 2024

Introduction

The hepatic growth factor (HGF) stimulates DNA synthesis and cell proliferation and plays a role in tissue protection and regeneration. In this study, we have examined the effect of incubation of HGF with urine-derived stem cells (USCs) on the secretion of small extracellular vesicles (sEV) by the cells.

Materials and Methods

HGF in the incubation medium was either a bolus administration or a controlled release of an equivalent amount from microbeads within the size range of 50–200 µm made with ultrapurified low-viscosity high-guluronic acid (UP-LVG) alginate. USCs were incubated with or without HGF for 3 days or 7 days before removal of the incubation media, followed by harvesting sEV by the precipitation method. The protein content of isolated sEV was measured by bicinchoninic acid assay (BCA) for these three groups: control (no HGF beads), bolus HGF, and HGF beads. We also performed nanoparticle tracking analysis (NTA), Western blot assay, and ELISA for the HGF content of samples.

Results

We found a significantly higher concentration of proteins in the HGF microbead group (control release group) compared to the bolus group and the control group after 7 days (p < 0.0017). The NTA data aligned with the BCA; they showed a significantly higher concentration of particles within the size range of sEV (<200 nm) in the group treated with HGF beads compared to the two other groups on day 7 (p < 0.0001).

Conclusion

We found that administration of HGF to USCs by controlled release of the growth factor significantly enhances the levels of sEV secretion during 7 days of incubation.
Integrating urban development and ecological sustainability: a study on land surface temperature and urban heat island effect in a Karst River Basin
Authors: Wu Yangyang , Wu Haobiao , Li Siliang , Wu Liqing , Guo Chunzi , Zhang Zhonghua , Fan Ruixue , Yang Xiaodong , Zhou Guanghong , Yang Jinli , Yuan Panli , Luo Guangjie
Published: August 2024

The Chishui River Basin, a vital waterway in Southwest China, has experienced rapid urbanization, leading to significant ecological and environmental changes, among which the urban heat island (UHI) effect is particularly pronounced. The UHI effect not only affects the quality of life for residents but also influences urban energy consumption and climate change, underscoring the need for in-depth study of its spatial distribution and contributing factors. The unique karst topography of the region further complicates UHI research, necessitating an investigation that can inform urban planning and sustainable development strategies. This study leveraged Landsat 8 TIRS satellite remote sensing imagery to examine the land surface temperature (LST) and UHI effect in the Chishui River Basin during the summers of 2016 and 2021. Employing the Mono-window Algorithm (MWA), the research quantitatively inverted the LST and analyzed its spatial distribution and the spatiotemporal characteristics of the surface urban heat island (SUHI) effect. The findings indicated a notable increase in average summer temperatures between the 2 years, with a 1.67°C rise from 2016 to 2021. Despite this increase, there was an observed reduction in the extent of SUHI areas, suggesting potential mitigation efforts. Additionally, the study revealed that karst regions were more susceptible to forming “abnormal” heat islands due to their distinct geomorphological features. The implications of this research are critical for urban development planning and the pursuit of sustainable urbanization in the Chishui River Basin. By understanding the thermal dynamics and their relationship with urbanization and karst landscapes, policymakers and urban planners can devise strategies to minimize the adverse effects of SUHI while promoting ecological balance and environmental health. Future research should extend the temporal analysis, employ higher resolution data, compare findings with other regions, and provide a detailed examination of mitigation efforts to enhance the robustness and applicability of the conclusions, provide stronger scientific evidence for the ecological sustainability of the Chishui River Basin.
Associations between SII, SIRI, and cardiovascular disease in obese individuals: a nationwide cross-sectional analysis
Authors: Liu Zhou , Zheng Longxuan
Published: August 2024

Background

Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are comprehensive markers of inflammatory status. However, the correlation between SII and SIRI and the prevalence of cardiovascular disease (CVD) in populations with obesity remains unknown.

Methods

This is a cross-sectional study with data obtained from the National Health and Nutrition Examination Survey from 1999 to 2018. SII and SIRI were calculated using the following equations: SII = (platelet count × neutrophil count)/lymphocyte count. SIRI = (neutrophil count × monocyte count)/lymphocyte count. Spearman’s rank correlation coefficient was used to assess the relationship between SII and SIRI and baseline variables. Logistic regression models and generalized additive model (GAM) with a spline smoothing function were used to evaluate the association between SIRI and CVD prevalence. Nomogram and receiver operating characteristic curve (ROC) analysis were used to assess the value of the risk prediction model.

Results

A total of 17,261 participants with obesity and SII and SIRI publicly available data were used for this study. Multivariate logistic regression analysis revealed that SIRI, rather than SII, was an independent risk factor for CVD prevalence. For every standard deviation increase in SIRI, there was a 13%, 15%, and 28% increase in the odds ratios of CVD prevalence (OR = 1.13, 95% CI: 1.04–1.22, P = 0.01), coronary heart disease (OR = 1.15, 95% CI: 1.05–1.26, P = 0.002), and congestive heart failure (OR = 1.28, 95% CI: 1.16–1.41, P < 0.001). ROC results demonstrated that SIRI had a certain accuracy in predicting CVD prevalence (AUC = 0.604), especially when combined with other variables used in the nomogram (AUC = 0.828). The smooth curve fitting regression analysis demonstrated a significant linear association between the risk of SIRI and the odds ratio of CVD prevalence (P for nonlinear = 0.275).

Conclusions

SIRI is a relatively stable indicator of inflammation and is independently associated with the prevalence of CVD. It may serve as a novel inflammatory indicator to estimate CVD prevalence in populations with obesity.
Developing mindsets for equity-focused continuous improvement: tracing shifts in an Ed.D. program using critical improvement science
Authors: Zumpe Elizabeth , Uy Phitsamay S. , Hakouz Abeer , Szczesiul Stacy Agee
Published: August 2024

Introduction

Two rising innovations in educational leadership development—using an equity lens and facilitating continuous improvement (CI)—depend upon leaders developing conducive mindsets for the work. However, little research has examined how educational leaders come to develop equity-focused CI mindsets. This is important given that countervailing habits of thinking are likely to develop within leaders’ typical work environments. This paper traces the extent to which an Ed.D. program centered around a pedagogy of critical improvement science can foster shifts from typical habits of thinking towards equity-focused CI mindsets.

Methods

Data consisted of 13 assignments and semi-structured interviews of six Ed.D. students participating in two parallel and interconnected courses during their first term. The two courses culminated in a common assessment: a White Paper about their equity-focused problem of practice and how their social identities shaped their understanding and role in addressing the problem. Through coding, analytic memos, and member checking, we traced patterns and shifts in students’ thinking over time around five key domains of learning: problem identification, problem diagnosis, use of evidence, social identity, and equity leadership practices.

Results

We found emergent mindset shifts for all six participants across all learning domains. Students demonstrated new insights about problem analysis and becoming evidence-informed and user-centered, challenging their initial framing of problems through a systems approach to diagnosing problem. These insights intersected with new understandings of their social identities and practices as equity leaders as they reflected on more oppressed and privileged aspects of their identity and wrestled with new understandings that acting as equity leaders would entail disrupting power dynamics and empowering others for collective learning and action.

Discussion

The results reveal the potential of developing equity-focused CI mindsets through leadership programs that intentionally integrate methods of CI with critical analysis of one’s social identity and leadership practices amid systems of oppression.