bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Meaning in Visual Memory: Face-Selective Brain Activity Predicts Memory for Ambiguous Face Stimuli
Authors: Brady Timothy F. , Alvarez George A. , Störmer Viola S.
Published: December 2018

How people process images is known to affect memory for those images, but these effects have typically been studied using explicit task instructions to vary encoding. Here, we investigate the effects of intrinsic variation in processing on subsequent memory, testing whether recognizing an ambiguous stimulus as meaningful (as a face vs as shape blobs) predicts subsequent visual memory even when matching the perceptual features and the encoding strategy between subsequently remembered and subsequently forgotten items. We show in adult humans of either sex that single trial EEG activity can predict whether participants will subsequently remember an ambiguous Mooney face image (e.g., an image that will sometimes be seen as a face and sometimes not be seen as a face). In addition, we show that a classifier trained only to discriminate between whether participants perceive a face versus non-face can generalize to predict whether an ambiguous image is subsequently remembered. Furthermore, when we examine the N170, an event-related potential index of face processing, we find that images that elicit larger N170s are more likely to be remembered than those that elicit smaller N170s, even when the exact same image elicited larger or smaller N170s across participants. Thus, images processed as meaningful, in this case as a face, during encoding are better remembered than identical images that are not processed as a face. This provides strong evidence that understanding the meaning of a stimulus during encoding plays a critical role in visual memory.

SIGNIFICANCE STATEMENTIs visual memory inherently visual or does meaning and other conceptual information necessarily play a role even in memory for detailed visual information? Here we show that it is easier to remember an image when it is processed in a meaningful way, as indexed by the amount of category-specific brain activity it elicits. In particular, we use single-trial EEG activity to predict whether an image will be subsequently remembered, and show that the main driver of this prediction ability is whether or not an image is seen as meaningful or non-meaningful. This shows that the extent to which an image is processed as meaningful can be used to predict subsequent memory even when controlling for perceptual factors and encoding strategies that typically differ across images.
The 1st John Wales Memorial Lecture 2018: Delivering better diabetes care – it’s about time!
Authors: Winocour Peter H
Published: December 2018

None
Hypogonadotropic hypogonadism and pituitary hypoplasia as recurrent features in Ulnar-Mammary syndrome
Authors: Galazzi Elena , Duminuco Paolo , Moro Mirella , Guizzardi Fabiana , Marazzi Nicoletta , Sartorio Alessandro , Avignone Sabrina , Bonomi Marco , Persani Luca , Bonati Maria Teresa
Published: December 2018

Ulnar-mammary syndrome (UMS) is characterized by ulnar defects, and nipple or apocrine gland hypoplasia, caused byTBX3haploinsufficiency. Signs of hypogonadism were repeatedly reported, but the mechanisms remain elusive. We aim to assess the origin of hypogonadism in two families with UMS. UMS was suspected in two unrelated probands referred to an academic center with delayed puberty because of the evident ulnar ray and breast defects in their parents. Clinical, biochemical and genetic investigations proved the existence of congenital normosmic IHH (nIHH) associated with pituitary hypoplasia in the two probands who were heterozygous for novelTBX3pathogenic variants. The mutations co-segregated with delayed puberty, midline defects (nose, teeth and tongue anomalies) and other variable features of UMS in the two families (absent axillary hairs and nipple hypoplasia, asymmetrical features including unilateral ulnar or renal abnormalities). The combined analysis of these findings and of the previous UMS reports showed delayed puberty and other signs of hypogonadism in 79 and 37% of UMS males, respectively. Proband 1 was followed up to adulthood with persistence of nIHH. In conclusion, UMS should be suspected in patients with delayed puberty and midline defects, including pituitary hypoplasia, in the presence of mild cues forTBX3mutation, even in the absence of limb malformations. In addition,TBX3should be included among candidate genes for congenital nIHH.
Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: a multicenter cohort study
Authors: Carlsen Esben Andreas , Fazio Nicola , Granberg Dan , Grozinsky-Glasberg Simona , Ahmadzadehfar Hojjat , Grana Chiara Maria , Zandee Wouter T , Cwikla Jaroslaw , Walter Martin A , Oturai Peter Sandor , Rinke Anja , Weaver Andrew , Frilling Andrea , Gritti Sara , Arveschoug Anne Kirstine , Meirovitz Amichay , Knigge Ulrich , Sorbye Halfdan
Published: December 2018

Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1–2 (G1–G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN G3) is largely unknown. We therefore aimed to assess the benefits and side effects of PRRT in patients with GEP NEN G3. We performed a retrospective cohort study at 12 centers to assess the efficacy and toxicity of PRRT in patients with GEP NEN G3. Outcomes were response rate, disease control rate, progression-free survival (PFS), overall survival (OS) and toxicity. We included 149 patients (primary tumor: pancreatic n = 89, gastrointestinal n = 34, unknown n = 26). PRRT was first-line (n = 30), second-line (n = 62) or later-line treatment (n = 57). Of 114 patients evaluated, 1% had complete response, 41% partial response, 38% stable disease and 20% progressive disease. Of 104 patients with documented progressive disease before PRRT, disease control rate was 69%. The total cohort had median PFS of 14 months and OS of 29 months. Ki-67 21–54% (n = 125) vs Ki-67 ≥55% (n = 23): PFS 16 vs 6 months (P < 0.001) and OS 31 vs 9 months (P < 0.001). Well (n = 60) vs poorly differentiated NEN (n = 62): PFS 19 vs 8 months (P < 0.001) and OS 44 vs 19 months (P < 0.001). Grade 3–4 hematological or renal toxicity occurred in 17% of patients. This large multicenter cohort of patients with GEP NEN G3 treated with PRRT demonstrates promising response rates, disease control rates, PFS and OS as well as toxicity in patients with mainly progressive disease. Based on these results, PRRT may be considered for patients with GEP NEN G3.
Insurance Mandates and Out-of-Pocket Spending for Children With Autism Spectrum Disorder
Authors: Candon Molly K. , Barry Colleen L. , Marcus Steven C. , Epstein Andrew J. , Kennedy-Hendricks Alene , Xie Ming , Mandell David S.
Published: December 2018

BACKGROUND:

The health care costs associated with treating autism spectrum disorder (ASD) in children can be substantial. State-level mandates that require insurers to cover ASD-specific services may lessen the financial burden families face by shifting health care spending to insurers.

METHODS:

We estimated the effects of ASD mandates on out-of-pocket spending, insurer spending, and the share of total spending paid out of pocket for ASD-specific services. We used administrative claims data from 2008 to 2012 from 3 commercial insurers, and took a difference-in-differences approach in which children who were subject to mandates were compared with children who were not. Because mandates have heterogeneous effects based on the extent of children’s service use, we performed subsample analyses by calculating quintiles based on average monthly total spending on ASD-specific services. The sample included 106 977 children with ASD across 50 states.

RESULTS:

Mandates increased out-of-pocket spending but decreased the share of spending paid out of pocket for ASD-specific services on average. The effects were driven largely by children in the highest-spending quintile, who experienced an average increase of $35 per month in out-of-pocket spending (P < .001) and a 4 percentage point decline in the share of spending paid out of pocket (P < .001).

CONCLUSIONS:

ASD mandates shifted health care spending for ASD-specific services from families to insurers. However, families in the highest-spending quintile still spent an average of >$200 per month out of pocket on these services. To help ease their financial burden, policies in which children with higher service use are targeted may be warranted.
The Use of Innovative Technologies to Guide Cardiac Procedures
Authors: Hügl Burkhard , Findeisen Zdravena
Published: December 2018

The advantages of intracardiac echocardiography (ICE) include shorter procedure times, reduced radiation exposure and the elimination of the need for general anesthesia. It is also effective in the safe performance of transseptal punctures. These have led to its increasing use in electrophysiology (EP) procedures. The use of ICE provides unrestricted access to the cardiac anatomy and guides interventional cardiac procedures by providing high-quality images of intracardiac structures and devices. As well as their use as imaging in catheter ablation of atrial fibrillation and other arrhythmias, ICE ultrasound catheters may be used in cardiac valve repair and the closure of atrial septal defects (ASDs). Integration of ICE catheters with electroanatomical mapping systems that construct three dimensional (3D) images have further increased the application of the technique. The use of magnetic navigation systems (MNS) have conferred further advantages including reduced exposure to fluoroscopy and increased operator comfort. This article presents four clinical cases and reviews clinical studies of these techniques.
Los escándalos de corrupción retratados por la prensa. El caso de El Banco Provincial de Santa Fe (Argentina) durante la segunda mitad del siglo xix
Authors: Garcilazo Romina
Published: December 2018

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Cultura política-judicial: gestión social del modelo del buen juez. Zona central de Chile, 1824-1875
Authors: Brangier Víctor
Published: December 2018

El artículo problematiza las actitudes y estrategias que desplegó José Mate Luna, pequeño agricultor de la zona central de Chile, en la querella criminal que abrió contra un juez de su territorio en la medianía del siglo xix, y examina las aristas de su “cultura política-judicial”. El documento integra expedientes por acusaciones criminales contra jueces legos, analizados a la luz del papel de la justicia en el mantenimiento de los equilibrios sociales en Hispanoamérica. Los resultados evidencian la gestión social del modelo del buen juez, noción que integró la cultura jurídica y política de la monarquía ibérica y de sus dominios americanos, que experimentaba profundos cambios en el siglo XIX.
Versión en punto menor del mapa Provincias Unidas de la Nueva Granada de Francisco José de Caldas
Authors: Mejía Macía Sergio Andrés
Published: December 2018

El artículo presenta y atribuye un mapa de Francisco José de Caldas hasta hoy desconocido, incorrectamente catalogado en el Archivo General de la Nación (agn), en Bogotá. En la primera sección, la atribución se sustenta en dos argumentos: el motivo y croquis del mapa, coincidentes con el incompleto Provincias Unidas de la Nueva Granada, y las artes para sugerir las montañas, propias de la cartografía tardía de Caldas. La segunda parte consiste en un estudio de naturaleza cronológica y progresiva sobre las razones de la inacabada producción cartográfica del payanés. Con recurso a sus memorias científicas, a otros mapas y a su correspondencia en el periodo 1795-1816, se explica, coyuntura tras coyuntura, su reticencia a componer el mapa general del Nuevo Reino de Granada, cuyo dibujo apenas emprendió en 1811 y nunca completó, a pesar de haberlo anunciado desde 1796 y habérsele comisionado desde finales de 1805.
Acute Moraxella catarrhalis airway infection of chronically smoke-exposed mice increases mechanisms of emphysema development: A pilot study
Authors: Fischer Katja , Doehn Jan-Moritz , Herr Christian , Lachner Carolin , Heinrich Annina , Kershaw Olivia , Voss Meike , Jacobson Max H. , Gruber Achim D. , Clauss Matthias , Witzenrath Martin , Bals Robert , Gutbier Birgitt , Slevogt Hortense
Published: December 2018

In chronic obstructive pulmonary disease (COPD), acute exacerbations and emphysema development are characteristics for disease pathology. COPD is complicated by infectious exacerbations with acute worsening of respiratory symptoms with Moraxella catarrhalis as one of the most frequent pathogens. Although cigarette smoke (CS) is the primary risk factor, additional molecular mechanisms for emphysema development induced by bacterial infections are incompletely understood. We investigated the impact of M. catarrhalis on emphysema development in CS exposed mice and asked whether an additional infection would induce a solubilization of pro-apoptotic and pro-inflammatory endothelial monocyte-activating-protein-2 (EMAPII) to exert its activities in the pulmonary microvasculature and other parts of the lungs not exposed directly to CS.

Mice were exposed to smoke (6 or 9 months) and/or infected with M. catarrhalis. Lungs, bronchoalveolar lavage fluid (BALF), and plasma were analyzed.

CS exposure reduced ciliated area, caused rarefaction of the lungs, and induced apoptosis. EMAPII was increased independent of prior smoke exposure in BALF of infected mice. Importantly, acute M. catarrhalis infection increased release of matrixmetalloproteases-9 and -12, which are involved in emphysema development and comprise a mechanism of EMAPII release.

Our data suggest that acute M. catarrhalis infection represents an independent risk factor for emphysema development in smoke-exposed mice.
Capsular Type, Sequence Type and Microbial Resistance Factors Impact on DNase Activity of Streptococcus agalactiae Strains from Human and Bovine Origin
Authors: Florindo Carlos , Barroco Cinthia Alves , Silvestre Inês , Damião Vera , Gomes João Paulo , Spellerberg Barbara , Santos-Sanches Ilda , Borrego Maria José
Published: December 2018

Extracellular deoxyribonucleases (DNases) contribute to the spread of pathogenic bacteria through the evasion from host innate immunity. Our main objective was to evaluate the production of extracellular DNases by human and bovine Streptococcus agalactiae clinical strains and perform a correlation of genetic lineages and DNase activity with capsular type, genetic determinants, clinical origin (colonization and infection), and host (human or bovine). DNase activity was evaluated by qualitative and quantitative assays for a collection of 406 human (n = 285) and bovine (n = 121) strains. All (121/121) bovine were isolated from mastitis and revealed to be DNase (+), indicating a putative pathogenic role in this clinical scenario. From the human S. agalactiae strains, 86% (245/285) showed DNase activity, among which all strains belonging to capsular types, namely, Ia, Ib, III-2, and IV. All CC17 strains (n = 58) and 56/96 (58.3%) of the CC19 displayed DNase activity. DNase (−) strains belonged to the CC19 group. However, the subcharacterization of CC19 S. agalactiae strains through multiple-locus variable number tandem repeat analysis (MLVA), antibiotic resistance, mobile elements, and surface proteins did not provide any distinction among DNase producers and non-producers.

The production of DNases by all human CC17 strains, about two-fifths of human CC19, and all bovine strains, suggest an important contribution of DNases to hypervirulence.
First record of Proechimys pattoni da Silva, 1998 (Rodentia, Echimyidae) in northwestern Bolivia
Authors: Sánchez-Vendizú Pamela , Cook Joseph A. , Wood James , Salazar-Bravo Jorge
Published: December 2018

Proechimys pattoni da Silva, 1998 is one of the 3 small-bodied species of Proechimys and its geographic range is only known in western Brazil and eastern and southern Peru. However, based on morphological and molecular analyses, we report P. pattoni from the lowland forest of Bolivia (Pando: Rio Madre de Dios, near San Rosa). This is the first report of P. pattoni in Bolivia and extends its distributional range 315 km to the southeast in the Amazon biogeographic region of Bolivia, representing the southeastern most record. Furthermore, we document the karyotype (2n = 40 / FN = 56) and morphological variation in diagnostic characters.
Lipomeningocele associated with diplomyelia in a dog
Authors: Ondreka Nele , Malberg Sara , Laws Emma , Schmidt Martin , Schulze Sabine
Published: December 2018

A 2-year-old male neutered mixed breed dog with a body weight of 30 kg was presented for evaluation of a soft subcutaneous mass on the dorsal midline at the level of the caudal thoracic spine. A further clinical sign was intermittent pain on palpation of the area of the subcutaneous mass. The owner also described a prolonged phase of urination with repeated interruption and re-initiation of voiding. The findings of the neurological examination were consistent with a lesion localization between the 3rd thoracic and 3rd lumbar spinal cord segments. Magnetic resonance imaging revealed a spina bifida with a lipomeningocele and diplomyelia (split cord malformation type I) at the level of thoracic vertebra 11 and 12 and secondary syringomyelia above the aforementioned defects in the caudal thoracic spinal cord. Surgical resection of the lipomeningocele via a hemilaminectomy was performed. After initial deterioration of the neurological status postsurgery with paraplegia and absent deep pain sensation the dog improved within 2 weeks to non-ambulatory paraparesis with voluntary urination. Six weeks postoperatively the dog was ambulatory, according to the owner. Two years after surgery the owner recorded that the dog showed a normal gait, a normal urination and no pain. Histopathological diagnosis of the biopsied material revealed a lipomeningocele which confirmed the radiological diagnosis.
Multimodale Therapie der kaninen Osteoarthritis – aktueller Stand und neue Optionen
Authors: Tünsmeyer Julia , Diehm Marius
Published: December 2018

Die Osteoarthritis des Hundes ist eine sehr oft vorkommende Erkrankung und die häufigste Ursache für chronische Schmerzen beim Hund. Durch eine progressive Degeneration des Gelenkknorpels sowie weiterer Gelenkstrukturen kommt es zur konsekutiven Entwicklung osteophytärer Zubildungen sowie Entzündungsreaktionen und Schmerz. Eine vollständige Heilung ist nicht möglich. Ein multimodales Behandlungsschema zielt darauf ab, das Fortschreiten der Erkrankung zu verlangsamen und die Lebensqualität des Hundes zu steigern. Der Artikel gibt einen Überblick zu den verschiedenen Therapieoptionen. Derzeit wird eine Vielzahl von Analgetika zur pharmazeutischen Therapie der Osteoarthritis eingesetzt. Für eine effektive Behandlung dieser Erkrankung ist eine antientzündliche Wirkung sehr wichtig, doch geht insbesondere die langfristige Anwendung antiinflammatorisch wirksamer Medikamente mit erheblichen Nebenwirkungen einher. Durch eine für den Hund neu zugelassene Wirkstoffklasse, die sogenannten Piprante, besteht die Hoffnung auf ein verbessertes Sicherheitsprofil bei der medikamentösen Therapie chronisch entzündlicher Gelenkerkrankungen.
BRCA1/2 Functional Loss Defines a Targetable Subset in Leiomyosarcoma
Authors: Seligson Nathan D. , Kautto Esko A. , Passen Edward N. , Stets Colin , Toland Amanda E. , Millis Sherri Z. , Meyer Christian F. , Hays John L. , Chen James L.
Published: December 2018

Background

Soft-tissue sarcomas (STS) describe a heterogeneous group of mesenchymal tumors with limited treatment options. Targeted therapies exist for BRCA1/2 gene alterations, but their prevalence and role have not been fully described in STS. Here, we present the largest effort to characterize the frequency of homologous recombination (HR) DNA repair pathway alterations in STS subtypes and highlight the unique nature of leiomyosarcoma (LMS).

Materials and Methods

DNA sequencing data were analyzed for HR pathway alterations for 1,236 patients with STS. DNA sequencing data from an additional 1,312 patients were used to confirm the prevalence of HR pathway alterations in LMS. Four uterine LMS (uLMS) patients with functional BRCA2 loss were evaluated for response to poly (ADP-ribose) polymerase (PARP) inhibition.

Results

In an unselected STS study population, BRCA2 alterations were identified in 15 (1%) patients, and homozygous BRCA2 loss was detected in 9 (<1%). However, subset analysis revealed that these BRCA2 alterations were concentrated in uLMS as compared with any other STS subtype. Notably, 10% of uLMS tumors had a BRCA2 alteration. We further report that PARP inhibitors had demonstrated durable clinical benefit in four uLMS patients with BRCA2 loss.

Conclusion

HR pathway alterations are rare in most STS. However, we identify uLMS to be enriched for BRCA2 loss and report the positive outcomes of a series of patients treated with PARP inhibitors. Our data suggest that patients with uLMS should be considered for somatic BRCA2 profiling. Prospective trials are necessary to confirm the efficacy of PARP inhibition in uLMS.
Biomarkers for Programmed Death-1 Inhibition in Prostate Cancer
Authors: Manogue Charlotte , Cotogno Patrick , Ledet Elisa , Lewis Brian , Wyatt Alexander W. , Sartor Oliver
Published: December 2018

Prostate cancer is the second leading cause of cancer death in American men. Despite the common nature of this disease, there is a poor understanding of biomarkers that predict responsiveness to immunotherapeutic agents such as the programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors. Herein we describe a case of complete remission with pembrolizumab therapy in a metastatic castrate-resistant prostate cancer patient with a complex germline MSH2 alteration (Boland inversion) in association with a tumor demonstrating high microsatellite instability. Potential utility of high mutational burden assessed by an experimental circulating tumor DNA assay is also shown. The literature concerning biomarkers for PD-1 inhibition is reviewed, including data for various mismatch repair gene deficiencies, microsatellite instability, tumor mutational burden, PD-L1 3' untranslated region mutations, selected POLE mutations, and biallelic CDK12 mutations. Taken together, although prostate cancer is generally believed to be a tumor unresponsive to PD-1 inhibition, careful dissection of tumor biology is able to provide an approach toward predictive biomarkers that has the potential for expanded clinical utility.

Key Points

Biomarkers for anti-PD1 and anti-PDL1 therapy are poorly defined in prostate cancer. Recent advances are defining new important classes of responsive patients.
Parameter estimation during dewatering in a shallow aquifer in Dubai, UAE
Authors: Paleologos Evan K
Published: December 2018

Coastal cities in the UAE lie on a flat terrain created by tidal inundation and with super-saline groundwater within a few metres of the ground surface. Construction requires almost always dewatering in order to allow activities to proceed in dry conditions. Due to the tidal environment, the proper conceptual and numerical model for dewatering that applies to coastal UAE locations is transient, radial flow to pumping wells in an unconfined aquifer. This work utilises two numerical codes to study flow conditions at a Dubai site. The value of the radial hydraulic conductivity was found to be consistent with the site’s geologic description and falls in the middle of the range of values for the observed horizontal hydraulic conductivities. The vertical hydraulic conductivity was representative of a silty-type material and was consistent with the value estimated through packer tests approximately in the middle of the saturated thickness.
A dinâmica da política constitucional: o que podemos extrair do caso “brown vs. board education”?
Authors: Leite Glauco Salomão
Published: December 2018

O presente artigo analisa importantes aspectos institucionais do crescente processo de empoderamento judicial que tem caracterizado o constitucionalismo brasileiro nos últimos anos. Em primeiro lugar, destaca fatores extrajurídicos que contribuem para um maior grau de interferência judicial em controvérsias constitucionais relevantes. Em segundo lugar, ressalta os riscos decorrentes de uma narrativa que põe os Tribunais como atores soberanos do constitucionalismo. Conclui apontando para dinâmica da política constitucional, onde juízes e atores políticos estabelecem canais de interação institucional na implementação de direitos fundamentais.
Luces y sombras del derecho fundamental al olvido
Authors: Garcete Juan Marcelino González
Published: December 2018

La humanidad ha avanzado en diversas áreas del saber, y ello genera, lógicamente el advenimiento de nuevos escenarios de ineludible interactuar. Somos conscientes, empero, que si bien es cierto que mayormente podríamos decir que son en beneficio de la humanidad, ello no es óbice para que se configure también, inconvenientes, situaciones no deseables, perjudiciales, etc.

Así, bajo el título de luces y sombras del derecho fundamental al olvido, analizaremos sucintamente este tema; puesto que el Derecho fiel a su naturaleza de ser sombra que sigue la realidad, para hacer posible la convivencia del ser humano en sociedad; advierte situaciones acontecidas en y como producto de la cada vez más masificada utilización de la Internet. Nos referimos, a la problemática —según nuestro modesto entender—que sobreviene a los efectos del incorrecto tratamiento de la información personal contenida en ella.
Florisztikai felmérések hibaforrásai I. „Jószándékú” flórahamisítások: „kakukk” a Medvesen
Authors: Csiky János , Lantos István
Published: December 2018

A tervezett cikksorozat a florisztikai térképezések, illetve az így keletkezett adatbázi­sok hibaforrásaira szeretné felhívni a figyelmet. E dolgozatban elsőként a „jószándékú” flórahamisítás esetét mutatjuk be egy kistáj, a Medves vidék példáján. Az adatok forrását azok a 2005-ben postázott levelek képezik, amelyeket Varga Ferenc az elsőszerző kérésére fogalmazott meg. A dolgozatban 10, a tájegység és/vagy a Pannonicum szempontjából növényföldrajzilag is jelentős faj (Adonis vernalis, Arum orientale, Asarum europaeum, Genista germanica, Phragmites australis, Pulsatilla grandis, P. nigricans, Salvia aethiopis, Viola alba, Xeranthemum annuum) átültetésének körülményeit listáz­zuk. A levelezésekből kiderül, hogy amatőr botanikusként milyen módon szólhatunk bele egy terület flórájának alakulásába. A fajok döntő részét Varga Ferenc déli irányból észak felé mozdította el, átlago­san mintegy 10 km-nyire az eredeti termőhelyüktől. Az Adonis vernalis és a Genista germanica kivételé­vel legalább egy áttelepítés sikeresen, meghonosodással végződött. A Salvia aethiopis esetében az új állomány csupán 1,25 km-nyire található Szlovákiától, ahol a faj már kifejezetten ritka, veszélyeztetett (EN) taxon.
USE OF SPACE AND INFORMATION TECHNOLOGIES IN EXCURSION AND TOURISTIC ACTIVITY
Authors: Vyshnevskyi V.
Published: December 2018

A large number of opportunities that are connected with achievements in space and information technologies can be used in excursion and tourist activity. The most significant among those are: visualization of territory in high quality, possibility to compare satellite images taken in different time period, designing of volumetric images, panoramic review of objects, opportunity to detect someone’s location via GPS, determination of road traffic, visualization of processes in the atmosphere, assessment of ecological state on certain area etc. The information about remote sensing and sources of satellite images, in particular, are given. This data can be found in the Google Earth program, Bing Maps, Yandex. In addition, satellite images can be found on the websites of the US Geological Service and the European Space Agency. Landsat and Sentinel satellites make the most prevalent images. Quite useful options of Google Earth program are “Search” and “Create routes” as first helps to find the objects on the surface of Earth and second to create the route from one point to another. The essence of STRM mission is analyzed. This information can be applied using Global Mapper program. It gives the possibility to create volumetric images of relief which are more realistic than geographical maps. The essence of GPS is described. This system gives the opportunity to fix on the geographic coordinates which are significant in tourism. Moreover, it allows getting similar information as to photos made on routes. Another practical program, which can be employed in excursion and tourism activity, is SAS.Planet. This platform has a functional option called Wikimapia, which helps to identify object names. Furthermore, SAS.Planet allows determining traffic congestion. This method is based on crowdsourcing. Some possible ways of ecological state assessment are described, which is also important for the tourism industry. The specific examples of how to use the resources and technologies mentioned above are depicted.
RESTORATION OF TOURISM OF LUGANSHCHINY IN THE POST-CONFLICT PERIOD: SOCIAL-GEOGRAPHICAL ASPECT
Authors: Zavarika G.
Published: December 2018

The possibilities of the restoration of tourist activity in the Luhansk region during the post-conflict period are considered. The geography of the tourist potential of the investigated territory is analyzed. The current state of the tourism industry, which experienced a significant decline in activity as a result of the conflict, is highlighted. The economic opportunities of tourism development in the region as an option for improving the socio-economic status are substantiated. It is proposed to develop the most promising types of tourism with an indication of specific tourist destinations with the purpose of forming a positive image of the region. Among the modern types of tourism, the most promising for the region are distinguished: health-improving, rural tourism (agrotourism), ecotourism, event tourism, industrial and religious tourism. It is proved that the development of tourism in the region is relevant because it can improve the socio-economic situation. It has been established that the revival of tourism will increase local incomes, create new workplaces, develop all industries related to the production of tourism services, including social and industrial infrastructure, intensify the activities of crafts, culture, and increase the living standards of the local population. Issues of development of new attractive tourist routes that are of interest to not only residents of Lugansk region, but also other regions, will promote the formation of a positive image of the region and, accordingly, the development of domestic tourism. It is established that the tourist-recreational branch of the economy of the region, taking into account the decline of tourism activity for 2014-2015, tends to slow growth. It is revealed that during the period of 2014-2016 in general, the Lugansk region has a tendency towards a slow increase in tourist fees. It is proved that tourism today is one of the most promising branches of economic activity in the post-conflict period. The necessity of awareness and desire of local communities to intensify internal regional tourism is emphasized.
Catheter-associated urinary tract infections in patients of TSBHI “Altai territory hospital for war veterans” urological unit
Authors: Sursyakova K. I. , Safyanova T. V.
Published: December 2018

Aim. To assess manifestations and risk factors of epidemiological process of catheter-associated urinary tract infections (UTI) in patients of the urological unit of “Altai Territory Hospital for War Veterans” (ATHWV).

Materials and methods. One hundred medical records of UTI patients, treated in this urological unit were analyzed to determine the association between the UTI sickness rate and the insertion of catheters among patients, treated in the urological unit of “Altai Territory Hospital for War Veterans” during 2017.

Results. Assessment of epidemiological process in catheter-associated UTI patients of “ATHWV” urological unit resulted in the following: UTI sickness rate in “ATHWV” is associated with urinary bladder catheterization and can be interpreted as health care-associated infections since all the observed patients underwent urinary tract catheterization procedure in conditions of “ATHWV” urological unit.

Conclusions. Microbiological urine analysis with determination of antibiotic-resistance and disinfectant-resistance of the excreted pathogens should be conducted in all the patients, who undergo urinary bladder catheterization procedure since there is a high percentage of microbiologically-evidenced symptomatic UTI (35.9 %).
Fenomena hamil di luar nikah di kalangan remaja ditinjau dalam perspektif pendidikan Islam
Authors: Syahri Akhmad , Afifah Lailia Anis
Published: December 2018

Mencuatnya fenomena hamil pranikah di kalangan remaja yang tidak segera ditangani akan menimbulkan konflik antar individu dan masyarakat. Oleh karena itu, diperlukan pendekatan Islami sebagai pisau analisisnya. Penelitian kualitatif dengan jenis studi kasus ini menggunakan pengumpulan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukan bahwa: 1) Fenomena hamil pranikah yang terjadi pada remaja di Kecamatan Jambu disebabkan oleh 3 faktor, yaitu: a) faktor perilaku: perilaku berpacaran yang terlalu bebas dan rasa penasaran terhadap hubungan seksual. b) faktor keluarga: perceraian, kurangnya perhatian orang tua terhadap anak, keluarga broken home, kondisi orang tua yang permisivisme dan jauh dari pendidikan Islam. c) faktor lingkungan: lingkungan pergaulan bebas, peluang yang mendukung untuk melakukan hubungan seksual. 2) Kondisi kehidupan remaja hamil pranikah, yaitu: a) lebih banyak bertanggung jawab. b) kebutuhan ekonomi masih dicukupi oleh orang tua. c) sebagian besar suaminya bekerja. d) kurang memahami nilai-nilai Islami sehingga hubungan setelah menikah ada yang harmonis dan bercerai. 3) Alasan remaja hamil pranikah, yaitu: a) orang tua tidak setuju. b) dicekoki minuman keras. c) rasa cinta terhadap pasangan. d) suka sama suka dan berniat melakukan hubungan seksual. e) ada kesempatan. 4) Islam memberi solusi tentang kasus ini melalui pernikahan.
Imprevisibilidad, contrato e imprevisión en el nuevo Código civil y comercial argentino
Authors: Grasso Manuel
Published: December 2018

Este trabajo problematiza el requisito de la imprevisibilidad como condición de aplicación de los remedios de adecuación o resolución del contrato previstos por el nuevo código civil y comercial argentino de 2014 para el supuesto de excesiva onerosidad sobrevenida. Pese a que el reciente texto normativo, a diferencia del sustituido, lo omite, la doctrina argentina y una incipiente jurisprudencia lo dan por existente. Tras un análisis del dispositivo legal y de las distintas interpretaciones, se propone una solución diversificada: la imprevisibilidad será un requisito cuando la onerosidad sobrevenida sea “excesiva”, pero no habrá de exigirse cuando, además de excesiva, sea manifiestamente “irrazonable o inicua”.
El sentido del fallo contemplado en el artículo 373.5 del Código general del Proceso: lo inane de la figura
Authors: Güette Hernández David Modesto
Published: December 2018

El artículo aborda una reflexión en torno a la figura del sentido del fallo, la cual fue implementada en el artículo 373.5 del código general del proceso, establecida como una excepción a la obligación de los jueces de emitir sentencia una vez finalizada la audiencia de instrucción y juzgamiento. El calificativo de inane, referido al sentido del fallo, corresponde a una crítica al desconocimiento de la complejidad de la decisión judicial, y a sostener que cuando el juez puede emitir el sentido del fallo, de igual manera puede emitir la sentencia, a menos que existan dificultades de tipo locativo o de tiempo; por ende, y en los restantes eventos, si no puede emitir la sentencia, por desconocimiento de la decisión que va a asumir, tampoco puede exigírsele que emita sentido del fallo.
Os limites dos negócios jurídicos processuais nas ações de família no direito brasileiro
Authors: Perazo Nunes de Carvalho Alexander , Martins Carmo Gabriela
Published: December 2018

O código brasileiro de processo civil de 2015 trouxe diversas inovações em seu bojo, entre elas os negócios jurídicos processuais. Este instituto visa possibilitar que as partes tenham mais liberdades e autonomia processuais, tornando o processo mais condizente com suas individualidades. Na presente pesquisa, busca-se justamente explicar um pouco mais deste instituto e analisar se ele pode ou não (e se sim, até que ponto) ser utilizado em ações familiares. Para tanto, a presente pesquisa foi dividida em três tópicos, além das considerações iniciais e finais, no qual o primeiro visa estudar este novo instituto em si, no segundo, analisar a autonomia privada no direito de família e no terceiro, avaliar se os negócios jurídicos processuais cabem em ações familiares. Vale salientar que a metodologia da pesquisa é eminentemente bibliográfica. Da pesquisa, concluiu-se que sim, cabe o uso de negócios jurídicos processuais em ações de família com base na sua autonomia privada.
ULUSLARARASI TİCARETİN GELECEĞİ İNSANSIZ GEMİLER: GZFT ANALİZİ VE HUKUKİ BOYUTLARI
Authors: ECE Nur Jale
Published: December 2018

Denizcilik taşımacılığında yakıt tüketimi, çevre
kirliliği ve insan hatasından kaynaklanan deniz kazalarını azaltmak ve yeşil
taşımacılık sağlamak amacıyla insansız gemiler denizcilik sektörünün
gündemindedir. İnsansız gemilerin; gemi sahipleri, daha fazla enerji
tasarrufu, seyir emniyeti ve çevre güvenliği açısından denizcilik sektörüne
birçok yararı olacaktır. Ancak insansız gemilerin; siber saldırılar, iş kayıpları, gemi adamlarının becerilerine olumsuz
etkileri, yüke ilişkin kazaların artması vb. yeni riskleri de beraberinde
getireceği düşünülmektedir. Çalışmanın amacı uluslararası ticaretin geleceği insansız
gemilerin güçlü ve zayıf taraflarını, fırsat ve tehditleri  (GZFT) ortaya koymak, insansız gemilerin
hukuki boyutlarını inceleyerek yapılması gereken hukuki ve teknik düzenlemelere
ilişkin önerilerde bulunmaktır. Çalışmada, dünyada insansız gemilere ilişkin
çalışmalar, sorunlar veriskler incelenmiş, insansız gemilerin Güçlü ve Zayıf
Yönler, Fırsatlar ve Tehditler (GZFT) Analizi yapılmış, 1982 Uluslararası Birleşmiş Milletler Deniz Hukuku Sözleşmesi,
Uluslararası Denizcilik Örgütü Sözleşmeleri, diğer uluslararası denizcilik
sözleşmeleri ve ulusal mevzuatta insansız gemiler ile ilgili düzenlemeler
gözden geçirilmiş olup, söz konusu mevzuatta yapılması gereken düzenlemelere
ilişkin öneriler verilmiştir.
TÜRK GEMİADAMLARININ DENİZCİLİK EĞİTİMİ VE DENİZDE ÇALIŞMA MEMNUNİYETİ HAKKINDAKİ GÖRÜŞLERİ ÜZERİNE BİR ARAŞTIRMA
Authors: YILMAZ Fatih
Published: December 2018

Bu çalışmada; Türk gemi çalışanlarının denizcilik eğitimi ve denizde çalışma memnuniyetleri hakkındaki görüşlerinin belirlenmesi, irdelenmesi ve bazı öneriler sunulması amaçlanmıştır. Bu amaçla bir anket formu oluşturularak 652 Türk gemi çalışanı üzerinde uygulanmıştır. Anket ile elde edilen veriler sınıflandırılmış ve SPSS 21 yazılımı ile analiz edilmiştir. Analiz sonucunda elde edilen başlıca bulgular şu şekildedir; anketin ilgili sorularını cevaplayan ‘Güverte’ ve ‘Makine’ sınıfı gemi çalışanlarının yaklaşık %50’si denizcilikle ilgili karada almış oldukları eğitimleri gemi hayatında ‘Yeterli’ ve ‘Çok yeterli’ bulurken, ‘Yardımcı’ sınıf gemi çalışanlarında bu oran %35 civarındadır. Yeterlik sınıflarına göre farklılık göstermekle birlikte, anketin ilgili sorularını cevaplayan gemi çalışanlarının genel olarak %50 ila 70’inin karada çalışma imkânı olsa gemide çalışmaya devam etmeyeceğini belirttiği görülmüştür. Karada çalışma isteği tüm yaş gruplarında %50’nin üzerinde olup 25-44 yaş arası katılımcılarda %68’e kadar çıkmaktadır. 24 yaş altı katılımcıların yaklaşık %60’ının karada çalışma imkânı olsa gemide çalışmaya devam etmeyeceğini belirtmiş olması ayrıca dikkat çekicidir. Sonuç itibariyle; denizcilik eğitimlerinin gemideki çalışma hayatındaki etkinliğinin ve fayda düzeyinin arttırılması, denizcilik öğrencilerinin kabulünde daha seçici bir sistem geliştirilmesi, gemiadamlarının işe alma ve yerleştirme süreçlerinin iyileştirilmesi, gemilerde tükenmişlik sendromunu önlemeye ve iş tatmin düzeyini arttırmaya yönelik daha fazla çabaya ihtiyaç olduğu değerlendirilmektedir.
Existem relações entre qualidade de vida no trabalho, comprometimento organizacional e entrincheiramento organizacional?
Authors: Milhome Jaqueline Cavalcante , Rowe Diva Ester Okazaki , Dos-Santos Marcos Gilberto
Published: December 2018

Uma vez reconhecendo-se a participação substancial do trabalhador no resultado organizacional, evidencia-se que a percepção acerca de diversos aspectos organizacionais pode influenciar e ser influenciada pelo tipo de vínculo que o trabalhador desenvolve com a organização. Nesse contexto, o presente estudo objetiva analisar as possíveis relações que podem se estabelecer entre a Qualidade de Vida no Trabalho e os vínculos Comprometimento e Entrincheiramento Organizacional. Para tanto, foi realizada uma pesquisa quantitativa e explicativa, cujo questionário foi composto por três escalas validadas, cada uma relacionada a um dos construtos investigados. A partir de uma amostra de 187 trabalhadores, os dados foram analisados a partir de Regressões Múltiplas. Os resultados confirmaram algumas hipóteses testadas e contribuiram para refletir sobre a importância da organização para o vínculo que o trabalhador desenvolve com a organização, bem como esses vínculos podem contribuir para a percepção acerca das práticas e posicionamentos organizacionais.
Publicidade e representação social da Naturologia em jornais e revistas não acadêmicas no Brasil
Authors: Oliveira Marcos Renato de , Vieira Daniele Vasconcelos Fernandes , Maranhão Thatiana Araujo , Torres Raimundo AugustoMartins
Published: December 2018

Objetivo: Identificar as representações sociais acerca da Naturologiadivulgados na mídia digital por jornais e revistas não acadêmicas no Brasil. Método: Pesquisa do tipo documental, realizada no acervo digital das revistas e jornais de maior circulação no Brasil. Os dados referentes à amostra de notícias foram processados no software IRAMUTEQ® e analisados a partir da freqüência, ocorrência e similitude entre os termos. A análise foi feita a luz da teoria da representação social por meio dos mecanismos de ancoragem e objetivação.Resultados: Foi possível identificar que a naturologia é representada em 4 grandes grupos (p<0,0001): formação profissional na área (31,0%), regulamentação governamental (26,7%), ensino de técnicas autoaplicáveis (25,4%), e práticas em grupos específicos (16,9%). Os assuntos são abordados objetivando apresentar a naturopatia como uma opção extra ao alcance do bem-estar. Conclusão: As representações da mídia colaboraram na apresentação da naturologiacomo uma formação acadêmica cercada de regulamentos, o que é um aspecto positivo, porém ainda é forte o caráter complementar e com aspectos negativos como temas centrais. Assim, considerando a influência destas mídias, faz-se necessário maior aprofundamento e acerca da representação social da Naturologia.
Educação a distância em Terapia Floral
Authors: Salles Léia Fortes , Turruni Ruth Natalia Teresa
Published: December 2018

Introdução: O crescimento de práticas educacionais online, como a Educação a distância, no mundo e no Brasil é um fato constatado. Cada vez mais instituições de ensino com diferentes objetivos e níveis educacionais oferecem cursos e disciplinas que empregam novas Tecnologias de Informação e Comunicação. Terapia floral é uma das Práticas Integrativas e Complementares da Saúde e utiliza as essências das flores para cuidar de aspectos mentais, emocionais e comportamentais das pessoas. Pode ser usada no nosso cotidiano, de forma preventiva ou restaurativa, promovendo melhora na qualidade de vida. Objetivo: Este projeto tem como objetivo principal analisar a satisfação dos inscritos no curso de Terapia Floral, na modalidade EaD. Método: Estudo observacional e descritivo, longitudinal com abordagem quantitativa e qualitativa. As ferramentas para a coleta de dados foram questionários respondidos online pelos voluntários antes e após os cursos. Resultados: As expectativas foram alcançadas para 93,3% dos participantes, que consideraram a plataforma de fácil manejo e material didático pedagógico adequado. A maioria considerou que a linguagem, o conteúdo e a metodologia utilizada favoreceram a aprendizagem. Considerações finais: O curso EaD introdutório em Terapia floral trouxe satisfação e conhecimento sobre o assunto aos participantes. Cumpriu seu objetivo no ensino e promoveu a inclusão, ao permitir a participação de indivíduos que teriam poucas chances de frequenta-lo devido a problemas principalmente de tempo e distância.
Avaliação histopatológica dos órgãos de camundongos com carcinoma de ehrlich tratados com cisplatina, acupuntura e euphorbia tirucalli l.
Authors: Dias Mirella , Nascimento Tamires Saches Santos do , Souza Ivone Antônia de , Lima Evilda Rodrigues de
Published: December 2018

Introdução: O câncer é uma das maiores causas de morte do mundo sendo considerado um problema de saúde pública. Objetivo: Objetivou-se realizar a avaliação histopatológica de órgãos de camundongos com carcinoma de Erhlich tratados com cisplatina, acupuntura e a planta Euphorbia tirucalli L.  Metodologia: Utilizou-se 25 camundongos, fêmeas, com 60 dias de idade, 25 e 35 g de peso corpóreo sendo divididos em Grupo 1 – Controle negativo - 1ml de Soro Fisiológico 0,9% (VO); Grupo 2 – Controle positivo - 2,5mg/kg de Cisplatina (VO); Grupo 3 - Pré-tratamento com acupuntura + 2mg/kg da Euphorbia tirucalli (VO); Grupo 4 – Acupuntura; Grupo 5 - Acupuntura + 2mg/kg Euphorbia tirucalli (VO). Inoculou-se células do carcinoma em todos os animais e durante 8 dias foi realizado os protocolos terapêuticos. No nono dia os camundongos foram pesados, eutanasiados por deslocamento cervical, necropsiados para avaliação macroscópica e histológica dos órgãos e do tumor. Os acupontos utilizados foram B10, VB30 e F3. Resultados: Houve variação significativa no peso dos órgãos (Rins, Baço, Fígado) e do Tumor. As principais alterações histopatológicas foram pneumonia, hepatite, necrose hepática, degeneração gordurosa e hiperplasia da polpa branca do baço. Conclusão: A cisplatina demonstrou ser o tratamento mais eficaz em camundongos com carcinoma de Erhlich quanto a redução do tumor. A dose utilizada na pesquisa do látex da Euphorbia tirucalli L. demonstrou ser hepatotóxica, no entanto os tratamentos com acupuntura e a planta proporcionaram uma resposta imunológica. Assim, sugere-se a associação da acupuntura e da Euphorbia tirucalli como tratamentos coadjuvantes em pacientes com carcinoma.Palavras-chaves: Câncer. Etnobotânica. Fitoterapia. Medicina Tradicional Chinesa.