bluuebunny/crossref_metadata_2025 huggingface dataset:
Gifted Children and Psychiatric Disorders: Is the Risk Increased Compared With Their Peers?
Authors: Aykutlu Hasan Cem , Dereli Fatih , Turan Bahadır , Türk Kurtça Tuğba , Dursun Onur Burak
Published: April 2024

This study examined the prevalence and correlates of psychopathology in gifted children (GC) and explored whether giftedness confers protection or risk for mental health problems. We used a comparative design to analyze a population-based sample of 100 GC and 100 controls matched by age and sex in Turkey. We assessed psychiatric diagnoses with the Development and Well-Being Assessment (DAWBA), a valid diagnostic tool for child and adolescent mental health, and measured resilience and temperament with standardized scales. GC and controls did not differ significantly in the frequency of psychiatric disorders. However, GC showed lower resilience and higher negative reactivity and activity than controls. Negative reactivity was a significant predictor of psychopathology in GC. Sex did not moderate the effects of giftedness on mental health outcomes, resilience, or temperament. Our findings suggest that GC may have increased vulnerability to stress and reduced coping skills. We highlight the need to identify and support GCs who experience mental health problems and face psychological challenges. Our results emphasize the importance of early intervention and prevention to enhance resilience and well-being in this population. Future research should investigate the underlying mechanisms and develop tailored strategies to support the mental health and well-being of GC.
In situ epoxidation of canola oil via peracetic acid mechanism-optimization and kinetic study
Authors: Abrar Shahrizan Ahmad Shauqi , Hanib Nurul Hazwani , Azmi Intan Suhada , Fauziyah Mar’atul , Jalil Mohd Jumain
Published: April 2024

Canola oil can serve as a substitute for polyol in the production of eco-friendly polyurethane. The aim of this study is to investigate the optimal conditions for the epoxidation of canola oil via the Taguchi optimization method. To date, there is no published work on optimization of process parameters for epoxidized canola oil production using the Taguchi method. In this study, the epoxidation of canola oil was performed using in situ-generated peracetic acid. Peracetic acid was formed by the reaction between acetic acid and hydrogen peroxide in the presence of a catalyst. The highest conversion to oxirane of 85% was achieved at a ratio of 2:1 of hydrogen peroxide to canola oil, a temperature of 65°C, and a stirring speed of 400 rpm. The Fourier-transform infrared spectroscopy (FTIR) characterization reveals the presence of the oxirane ring group, identified at a wavenumber of 1150 cm−1. Employing particle swarm numerical simulations, the results exhibit excellent agreement with the experimental data, thereby confirming the accuracy and validity of the kinetic model.
Investigations on morphology, tribology, rheology, thermo-mechanical properties, and EMI shielding of WC/MWCNT nanohybrids in polypropylene
Authors: Leena Snaha , Nanoth Rasana , Karingamanna Jayanarayanan , B Sabarish Narayanan , Bhagavatula Sai Gopal Krishna , Rajan Krishna Prasad , Gopanna Aravinthan
Published: April 2024

This study is focused to explore the synergism of dual nanofillers (tungsten carbide (WC) and multiwalled carbon nanotubes (MWCNTs)) in melt extruded PP composites. The synergy of fillers in PP enhanced the elastic modulus, tensile strength, and critical stress intensity factor by 141.8%, 35.4%, and 62.6%, respectively, at an optimum filler content of 1 wt% of WC and 2 wt% of MWCNTs. In the hybrid composites, activation energy to initiate thermal decomposition raised by 78% and wear resistance increased by 93%, and the hybrid composites exhibited enhanced reflectivity in the X band region, which contributed to high electromagnetic shielding effectiveness. The improvement in the properties makes the current hybrid composite system an ideal candidate in application sectors where high modulus, energy absorption, and thermal stability are required.
Occurrence of alkyl glucosides in rinse-off cosmetics marketed as hypoallergenic or for sensitive skin
Authors: Ćirin Dejan , Milutinov Jovana , Krstonošić Veljko
Published: April 2024

Rinse-off cosmetic products, primarily shampoos, are frequently implicated in the onset of allergic contact dermatitis (ACD) caused by alkyl glucosides (AGs). AGs are increasingly popular surfactants and known contact allergens. Glucoside-induced ACD was most frequently observed with shampoos and skin-cleansing products in both consumer and occupational settings. Thereby, studies have shown that atopic individuals are the most susceptible to ACD. Also, several investigations have indicated that individuals with sensitive skin might be more prone to skin allergies. This is why the presence of AGs was investigated in shampoos and body cleansers marketed as hypoallergenic or for sensitive skin. For this purpose, the website of Amazon.com was surveyed. Four groups of cosmetics were obtained by using the following keywords: “hypoallergenic shampoo for adults,” “sensitive skin shampoo for adults,” “hypoallergenic body cleanser for adults,” and “sensitive skin body cleanser for adults.” The first 30 best-selling cosmetics in each group were investigated for the presence of AGs, by analyzing the product information pages. The results showed that as much as 56.7% of hypoallergenic shampoos contained AGs, as ingredients, whereas the percentage was somewhat lower for other product categories. Even though decyl and lauryl glucoside were nearly ubiquitously used AGs in cosmetics over the past decade, the most commonly present AG in our analysis was coco-glucoside. The results of this study indicated a necessity to include coco-glucoside in the baseline series of patch testing allergens. Industry , regulators, and healthcare providers should be made aware of the frequent presence of AGs in rinse-off cosmetic products marketed as hypoallergenic or for sensitive skin to ensure the safety and well-being of consumers and patients.
Noninvasive Ventilation in the Cardiac Intensive Care Unit
Authors: Schenck Christopher S. , Chouairi Fouad , Dudzinski David M. , Miller P. Elliott
Published: April 2024

Over the last several decades, the cardiac intensive care unit (CICU) has seen an increase in the complexity of the patient population and etiologies requiring CICU admission. Currently, respiratory failure is the most common reason for admission to the contemporary CICU. As a result, noninvasive ventilation (NIV), including noninvasive positive-pressure ventilation and high-flow nasal cannula, has been increasingly utilized in the management of patients admitted to the CICU. In this review, we detail the different NIV modalities and summarize the evidence supporting their use in conditions frequently encountered in the CICU. We describe the unique pathophysiologic interactions between positive pressure ventilation and left and/or right ventricular dysfunction. Additionally, we discuss the evidence and strategies for utilization of NIV as a method to reduce extubation failure in patients who required invasive mechanical ventilation. Lastly, we examine unique considerations for managing respiratory failure in certain, high-risk patient populations such as those with right ventricular failure, severe valvular disease, and adult congenital heart disease. Overall, it is critical for clinicians who practice in the CICU to be experts with the application, risks, benefits, and modalities of NIV in cardiac patients with respiratory failure.
Forecasting the total building energy based on its architectural features using a combination of CatBoost and meta-heuristic algorithms
Authors: Qu Xiaoyu , Liu Ziheng
Published: April 2024

This research examines the overall energy usage in residential buildings, focusing on architectural characteristics. The study utilizes a combination of the CatBoost method and meta-heuristic algorithms for analysis. The main approach of this research is based on the accuracy defects of individual models, which leads to the employment of CatBoost as a group model. Due to the lack of enough examinations while utilizing CatBoost method, this model and its hyperparameters are optimized using various meta-heuristic methods, including Phasor Particle Swarm Optimization (PPSO), Slime Mould Algorithm (SMA), Sparrow Search Algorithm (SSA), Ant Lion Optimizer (ALO), Artificial Bee Colony (ABC), and Grey Wolf Optimizer (GWO). Eventually, the performance of all models is compared by conduction of a case study, using diverse statistical examination indexes divided by the dwelling types i.e., (1) Standard efficiency upgraded dwellings (D1), (2) High efficiency upgraded dwellings (D2), and (3) Ultra high efficiency upgraded dwellings (D3). The results show that the hybrid proposed method has a proper ability to investigate the total site energy. The results show that for the D1 dwelling and according to the test dataset, the integrated CatBoost-SMA model indicates the most desired performance in predicting the total site energy. But for D2 and D3 dwellings and referring to the test dataset, the statistical evaluation indexes emphasize that the integrated CatBoost-PPSO method shows the most reliable performance.
Robust H∞ control of heterogeneous connected vehicles platoon with random time-varying communication delay
Authors: Ru Shuangkun , Jiao Xiaohong
Published: April 2024

As an essential component of intelligent transportation systems (ITS), connected cruise control (CCC) has attracted much attention due to its potential to improve vehicle safety and reduce traffic congestion. However, besides the disturbance acting on the head vehicle of the platoon, the time-varying communication delay in vehicle-to-vehicle (V2V) also seriously impacts the CCC system’s stability. In this paper, we investigate a robust control scheme utilizing the Lyapunov-Krasovskii functional stability theory and [Formula: see text] technique to ensure the stability of the CCC system consisting of the connected and automated vehicle (CAV) and connected human-driven vehicles (CHVs) under random time-varying communication delay. The effectiveness and advantage of the designed robust controller are verified by MATLAB/Simulink simulation and comparison with the existing result of the literature.
Governing public investment in Europe: The politics of off-balance-sheet policymaking, the rise of Eurostat and contrasted regional policies in Belgium
Authors: Piron Damien
Published: April 2024

This paper focuses on a neglected yet crucial feature of public investment policies in the European Union (EU): the politics of statistical harmonization and off-balance-sheet policymaking. Drawing upon the instrument-centred approach and the sociology of quantification and accounting, it refines the concept of ‘fiscal ecosystem’ by highlighting the controversial and evolving nature of the boundary between on- and off-balance-sheet recording. It is argued that the accounting aggregates giving effect to EU fiscal rules favour marketized and privatized modes of public service delivery, including ‘market-based but state-led’ off-balance-sheet investment tools such as public–private partnerships. However, the effectiveness of this policy has decisively hinged upon the work of harmonizing public finance statistics carried out by Eurostat, the Statistical Office of the EU. This contested process has led to acute power struggles between statistical agencies and governments, and a substantial increase of Eurostat’s power in the wake of the Eurozone crisis. The comparison of the two main Belgian regions highlights contrasting responses to this European strategy of governing (sub)national investment policies through fiscal rules and statistical harmonization: while Flanders has consolidated the financialization of its investment policy, Wallonia has so far opposed this trend. This demonstrates that although financialization of public investment is promoted by EU fiscal integration, it is not inevitable; governments do have some leeway to follow an alternative path. As Wallonia also benefited from extraordinary economic and political circumstances, it remains to be seen whether its distinctive investment policy will withstand rising interest rates and tighter fiscal rules.
Religious and Counseling Discourses in Clinical Practice
Authors: Pearson Lisa , Bradley Loretta , Southern Stephen
Published: April 2024

The study expands the authors' previous findings to examine counseling and religious discourses more closely. Three themes were identified: value of Catholic Christian faith for life and counseling; autonomy and obedience; and healing, renewal, and the call to serve. Interview transcripts were reviewed through the lens of constructs from discourse analysis, including hegemony, analogization, and dialogism. Dialectics between the domains of counseling and religion were identified in the samples of discourses and their analyses. The results indicate the potential for integration of domains and strengthening of religious and counselor identities.
Slaying the Toothless Tiger: Social Equity as the Legal Element of the Blue Economy
Authors: Schweinberg Marcus J. , Raspotnik Andreas
Published: April 2024

The ‘blue economy’ is slowly emerging as a catch-all concept that captures the goals of sustaining economic development opportunities while simultaneously maintaining ocean ecosystem health. However, identifying the scope and boundaries of the blue economy has proven to be a challenging task. The aim of this article is to provide a new approach to finding a practical definition of the blue economy. Social equity is noted as the legal component and balancing mechanism that operates between the economy and the environment. This legal compensation mechanism has so far only been rudimentarily elaborated on in governance texts and must be given concrete form through legal methods and, in particular, through the creation of an institutional and procedural framework. The article introduces the idea that an advanced legal concept for the blue economy can be realised by using existing administrative processes and by strengthening the participation of private actors within these processes.
The governance of possible futures and the regime of modern historicity: Critical theory and the modality of possibility
Authors: Guéguen Haud , Jeanpierre Laurent
Published: April 2024

The inaugural project of German Critical theory was to break away from the cult of facts in order to investigate the real possibilities of the present. Part of sociology has also made the possible and the relationship to the possible its central object. Such a task has met with a considerable effort on the part of government agencies to pre-empt the legitimate definition of what is possible. The social sciences were mobilised to this end. We offer a schematic account of these efforts in order to situate the extent to which the definition of possible futures is an issue of struggle in which Critical theory and sociology have a role to play. The article examines the question of the future through its close link to the category of the possible, at two levels that are often treated separately: at the level of the problem of ‘governmentality’ and its close link to the question of forecasting and probability; and at the level of the ‘regimes of historicity’ from which to consider the possible with a view to collectively reappropriating the determination of the future.
Sub-ulcer Foam Sclerotherapy in Patients with Venous Leg Ulcer, Analysis and Technical Aspects of 134 Consecutive Patients
Authors: Pihlaja Toni , Kosunen Emmi , Ohtonen Pasi , Pokela Matti
Published: April 2024

Objective

For this retrospective study, we analyzed the sub-ulcer foam sclerotherapy technique in patients with venous leg ulcer (VLU).

Methods

This study included 134 patients treated with sub-ulcer foam sclerotherapy at the Oulu University Hospital vascular outpatient clinic from January 2012 to December 2021. All included patients received sub-ulcer foam sclerotherapy as part of the treatment strategy for superficial venous insufficiency. Compression therapy and local wound care were organized for VLU treatment. A follow-up visit was scheduled for one month after the sub-ulcer foam sclerotherapy. Change in ulcer size, local (skin necrosis, infection) or systemic (deep vein thrombosis, pulmonary embolism) complications, and time to ulcer healing were monitored. The occurrence of major limb-related complications (amputation, surgical revision) was monitored for one year postoperatively.

Results

One month after sub-ulcer treatment, ulcers were smaller or completely healed in 108 (81%) patients. Ulcer healing was completed in 123 (92%) patients at one year and 131 (98%) patients at two years. Complications were recorded in four (3%) patients, three (2%) who were diagnosed with erysipelas requiring antibiotic treatment and one (1%) patient diagnosed with local dermatitis. During the one-year follow-up, no major limb-related complications (surgical revisions or amputations) arose.

Conclusions

Sub-ulcer foam sclerotherapy may be a feasible addition to superficial vein reflux elimination in patients with VLU and a low risk for complications.
Neoliberal, trouble-free worlds for an aspirational middle-class in Chinese EFL publications: A multimodal critical discourse analysis
Authors: Zhang Lili , Smith Christopher A
Published: April 2024

For most English language learning engagements in expanding circle countries, textbooks play a key role in defining a syllabus and corralling students toward some measure of completion in a course of study. While scholars have shown how English is broadly seen as a prestigious skill, connected with upward socio-economic mobility, less work has been done on the discourses and ideologies carried by the textbooks, even though this is a billion-dollar-a-year industry with titles selling in the millions. Research clearly raises the need for further investigations of the discourses and world views that they carry as they appear in different territories. In this paper, using Multimodal Critical Discourse Analysis, we analyze a corpus of texts books produced domestically within China. In China, English language learning has become a fundamental part of the aspirations of the emerging middle classes, who also tend to consume Western-style products and increasingly take on more individualistic Western-style values. Analysis shows that these textbooks carry language learning activities which combine a gloss of signifiers of more local, cultural ideas embedded in a privileged world inhabited by an aspirational, international middle-class.
“Overgrown Children” and Where to Find Them: Film Portrayals of Coresiding and Residentially Independent Siblings’ Developmental Maturity
Authors: Gelech Jan M. , Wellsch Jordan , Smith Brenan , Mazurik Kathrina , Holt Paris
Published: April 2024

Though young adult coresidence (in which individuals aged 18–35 reside within the family home) is stigmatized in mass media, research has not explored how such depictions relate to understandings of development. We used qualitative content analysis to explore how contemporary Canadian and American films depicted coresiding young adults and their similarly aged, residentially independent siblings with respect to various markers of adulthood. We found that coresiding characters were largely portrayed as developmentally immature both socially (e.g., full-time work) and characterologically (e.g., relational competence). In contrast, residentially independent siblings were overwhelmingly cast as developmentally on time. We argue that these depictions and contrasts reinforce a stigmatized coresider trope, framing the traits and actions of coresiders in terms of atypical development and attributing this living arrangement to individual faults. Implications for social attitudes and the wellbeing of emerging adults are discussed.
Association Between Psychological Readiness to Return to Sports at 3 Months Postoperatively and Risk of Second ACL Injury
Authors: Ueda Yuya , Matsushita Takehiko , Shibata Yohei , Takiguchi Kohei , Ono Kumiko , Kida Akihiro , Nishida Kyohei , Nagai Kanto , Hoshino Yuichi , Matsumoto Tomoyuki , Sakai Yoshitada , Kuroda Ryosuke
Published: April 2024

Background:

Psychological readiness to return to sports (RTS) has been associated with second anterior cruciate ligament (ACL) injury. However, this relationship is controversial because covariates such as anatomic and knee function characteristics have not been adequately considered.

Purpose/Hypothesis:

To investigate whether psychological readiness in the early postoperative period can predict the occurrence of a second ACL injury within 24 months after primary ACL reconstruction (ACLR) using propensity score analysis. It was hypothesized that patients with high ACL–RSI after injury (ACL-RSI) scores at 3 months postoperatively would have a second ACL injury within the projected postoperative period.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Included were 169 patients who underwent primary ACLR using hamstring tendon autografts between November 2017 and July 2021 and also underwent knee functional assessments at 3 months postoperatively. The ACL-RSI scale was used to assess psychological readiness for RTS. A second ACL injury was defined if ipsilateral or contralateral ACL injury was confirmed by examination within 24 months postoperatively. Based on a previous study showing that 65 was the highest cutoff value for the ACL-RSI score for RTS, we classified patients into 2 groups: those with high ACL-RSI scores (≥65; group H) and those with low ACL-RSI scores (<65; group L). We generated 1-to-1 matched pairs using propensity score analysis and used log-rank testing to compare the rate of second ACL injury between the 2 groups.

Results:

More patients returned to any sports activities within 12 months in group H than in group L (90% vs 73%; P = .03). A second ACL injury within 24 months postoperatively was identified in 7% of patients (13/169). The rate of second ACL injury was significantly higher in group H than in group L (17.6% vs 3.4%; P = .001). In 43 matched pairs extracted using propensity scoring, the rate of second ACL injury was also higher in group H than in group L (18.6% vs 4.7%; P = .04).

Conclusion:

Patients with a higher ACL-RSI score at 3 months exhibited a significantly higher incidence of second ACL injury within 24 months after primary ACLR.
Factors Influencing Generation Z Bachelor of Nursing Students’ Decision to Choose Nursing as a Career: A Pilot Study
Authors: Lommi Marzia , Ricci Simona , Ivziku Dhurata , Filomeno Lucia , Badolamenti Sondra , Notarnicola Ippolito , Stievano Alessandro , Rocco Gennaro , Latina Roberto , Giannetta Noemi , Covelli Giuliana , Romigi Gaetano , Pozzuoli Gianluca , Bove Davide , Porcelli Barbara
Published: April 2024

Introduction

Despite nurses representing the largest healthcare professional group, the number is not enough for global health coverage. Understanding Generation Z students’ intrinsic and extrinsic motivations, internal and external influences, and beliefs in choosing nursing education is crucial. This knowledge empowers universities to enhance nursing program enrollment through targeted promotion and recruitment strategies.

Objective

The aim was to understand why Italian students of Generation Z choose the Nursing Degree Course.

Methods

In this pilot study, a cross-sectional design was used. A survey with closed and open answers analyzing demographics, opinions, and motivations among new enrolled nursing students was administered on the first day of the Bachelor of Nursing Degree course. Descriptive statistics were used. Quantitative data were analyzed with Chi-square and ANOVA tests and qualitative data underwent content analysis and coding. Correlation analysis explored relationships between qualitative and quantitative results.

Results

Forty first-year students (85% female, average age 22) completed the questionnaire. The choice of the degree pathway, as the first or second option, is influenced by intrinsic and extrinsic motivations, the student's opinions, and family and social influences. Significant positive and negative associations were evidenced. Negative factors affecting choice included location and the responsibility for nursing care, while positive factors included role models, family advice, passion, curiosity for healthcare, the desire to help others, and family influences on decision-making.

Conclusions

Among Italian generation Z students, the choice of the nursing degree pathway is influenced by social models, family advice, passion, the desire to help others, and curiosity. Universities should be more proactive in their recruitment and promotion efforts, transforming these events into vibrant meeting points for professionals from diverse nursing specialties. They should also implement robust information policies that highlight career possibilities spanning clinical practice, management, education, and research areas within the field.
Assessment of the cytotoxic effect of carboxymethyl chitosan-loaded amygdalin nanoparticles against human normal and cancer cell lines
Authors: El-Houssiny A. S. , Soliman A. A. F. , Abdel-Nour K. N.
Published: April 2024

In recent years, the development of antitumor drugs has been dedicated to natural products. Amygdalin is a natural herbal cyanoglycoside that has anticarcinogenic effect on many types of cancers once hydrogen cyanide (HCN) is released. The main objective of the present study is to synthesize and investigate the potential of carboxymethyl chitosan nanoparticles (CMC NPs) as drug delivery agents for amygdalin encapsulation and its delivery to cancer and normal cell lines. In this study, carboxymethyl chitosan nanoparticles encapsulated with amygdalin (CMC-Am NPs) were prepared and characterized through their particle size, surface charge, chemical structure and dielectric properties. Also, the invitro drug release of amygdalin from CMC NPs was studied. Additionally, the cytotoxcity of the amygdalin and CMC-loaded amygdalin NPs were evaluated through MTT assay. The results showed that the prepared CMC-loaded amygdalin NPs exhibited a small particle size of 129 nm, high zeta potential value of − 43 mV and confirmed the amygdalin stability and compatibility with CMC NPs. Furthermore, the CMC NPs demonstrated sustained release of amygdalin during 24 h. Moreover, compared to free amygdalin, amygdalin-loaded CMC NPs have significant anti-cancerous effect on human colon HCT-116 and breast MCF-7 cancer cell lines while being safe on normal cells BJ1. In conclusion, CMC NPs can be employed as an efficient drug delivery vehicle for controlled and sustained amygdalin release with enhanced cytotoxicity on malignant cells without harming normal cells.
Effect of stress urinary incontinence on vaginal microbial communities
Authors: Zhang Man , Zhou Yanhua , Yao Siqi , Zhao Yiming , Batool Syeda Sundas , Huang Jing , Jiang Li , Yan Dayu , Yan Wenguang , Yu Zheng
Published: April 2024

Background

Postpartum women often experience stress urinary incontinence (SUI) and vaginal microbial dysbiosis, which seriously affect women’s physical and mental health. Understanding the relationship between SUI and vaginal microbiota composition may help to prevent vaginal diseases, but research on the potential association between these conditions is limited.

Results

This study employed 16S rRNA gene sequencing to explore the association between SUI and vaginal dysbiosis. In terms of the vaginal microbiota, both species richness and evenness were significantly higher in the SUI group. Additionally, the results of NMDS and species composition indicated that there were differences in the composition of the vaginal microbiota between the two groups. Specifically, compared to postpartum women without SUI (Non-SUI), the relative abundance of bacteria associated with bacterial dysbiosis, such as Streptococcus, Prevotella, Dialister, and Veillonella, showed an increase, while the relative abundance of Lactobacillus decreased in SUI patients. Furthermore, the vaginal microbial co-occurrence network of SUI patients displayed higher connectivity, complexity, and clustering.

Conclusion

The study highlights the role of Lactobacillus in maintaining vaginal microbial homeostasis. It found a correlation between SUI and vaginal microbiota, indicating an increased risk of vaginal dysbiosis. The findings could enhance our understanding of the relationship between SUI and vaginal dysbiosis in postpartum women, providing valuable insights for preventing bacterial vaginal diseases and improving women’s health.
Impact of Limosilactobacillus fermentum probiotic treatment on gut microbiota composition in sahiwal calves with rotavirus diarrhea: A 16S metagenomic analysis study”
Authors: Murtaza Nadeem , Nawaz Muhammad , Yaqub Tahir , Mehmood Asim Khalid
Published: April 2024

Background

Diarrhea poses a major threat to bovine calves leading to mortality and economic losses. Among the causes of calf diarrhea, bovine rotavirus is a major etiological agent and may result in dysbiosis of gut microbiota. The current study was designed to investigate the effect of probiotic Limosilactobacillus fermentum (Accession No.OR504458) on the microbial composition of rotavirus-infected calves using 16S metagenomic analysis technique. Screening of rotavirus infection in calves below one month of age was done through clinical signs and Reverse Transcriptase PCR. The healthy calves (n = 10) were taken as control while the infected calves (n = 10) before treatment was designated as diarrheal group were treated with Probiotic for 5 days. All the calves were screened for the presence of rotavirus infection on each day and fecal scoring was done to assess the fecal consistency. Infected calves after treatment were designated as recovered group. Fecal samples from healthy, recovered and diarrheal (infected calves before sampling) were processed for DNA extraction while four samples from each group were processed for 16S metagenomic analysis using Illumina sequencing technique and analyzed via QIIME 2.

Results

The results show that Firmicutes were more abundant in the healthy and recovered group than in the diarrheal group. At the same time Proteobacteria was higher in abundance in the diarrheal group. Order Oscillospirales dominated healthy and recovered calves and Enterobacterials dominated the diarrheal group. Alpha diversity indices show that diversity indices based on richness were higher in the healthy group and lower in the diarrheal group while a mixed pattern of clustering between diarrheal and recovered groups samples in PCA plots based on beta diversity indices was observed.

Conclusion

It is concluded that probiotic Limosilactobacillus Fermentum N-30 ameliorate the dysbiosis caused by rotavirus diarrhea and may be used to prevent diarrhea in pre-weaned calves after further exploration.
A novel efficient multi-walled carbon nanotubes/gibberellic acid composite for enhancement vase life and quality of Rosa hybrida cv. ‘Moonstone’
Authors: El-Naggar Hany M. , Ali Shimaa M. , Osman Amira R.
Published: April 2024

The postharvest life of cut flowers is limited, which is a major challenge and varies greatly depending on plant varieties, cut flower stage, flower length of the harvested shoots, and storage conditions including postharvest treatments. As a result, improving the vase life and quality of cut flowers in regulating postharvest characteristics and overcoming these challenges is critical to the horticulture business. Novel engineered nanocomposites were created and tested for possible impacts on flower bud opening, postharvest life extension, longevity regulation, and preservation and enhancement of the strength and appearance of cut flowers. The experiment was conducted as a factorial experiment using a completely randomized design (CRD) with two factors. The first factor was two holding solutions (without or with sucrose at 20 gL−1). The second factor was 12 pulsing treatments for 24 h; distilled water as a control, 75 ppm GA3, multi-walled carbon nanotubes MWCNTs at 10, 20, 30, 40, and 50 ppm, and MWCNTs (10, 20, 30, 40, and 50 ppm)/GA3 (75 ppm) composites; each treatment had 3 replicates, for a total of 72 experimental units. In the present study, gibberellic acid (GA3) was synthesized in functionalized (MWCNT/GA3 composites) as a novel antisenescence agent, and their effect on the vase life quality of cut rose flowers Rosa hybrida cv. ‘Moonstone’ was compared by assaying several parameters critical for vase life. The adsorption of GA3 on MWCNTs was proven by performing FTIR spectroscopy which ensures that the formation of the MWCNTs/GA3 composite preserves the nanostructure and was examined by high-resolution transmission electron microscopy (HR-TEM). The results revealed that sucrose in the holding solution showed a significant increase in fresh weight, flower diameter, and vase life by 10.5, 10.6, and 3.3% respectively. Applying sucrose with MWCNTs 20 ppm/GA3 75 ppm composites or MWCNTs 20 ppm alone, was critical for the significant increase in flower opening by 39.7 and 28.7%, and longevity by 34.4 and 23.2%, respectively, and significantly increased chlorophyll a, b, total chlorophyll, anthocyanin, total phenolic content, and 2,2-Diphenyl-1-picrylhydrazyl scavenging activity as compared to the control.
Echocardiographic features of right ventricle in septic patients with elevated central venous pressure
Authors: Zhang Hongmin , Zhang Dingding , Lian Hui , Zhang Qing , Chen Xiukai , Wang Xiaoting
Published: April 2024

Background

Elevated central venous pressure (CVP) is deemed as a sign of right ventricular (RV) dysfunction. We aimed to characterize the echocardiographic features of RV in septic patients with elevated CVP, and quantify associations between RV function parameters and 30-day mortality.

Methods

We retrospectively reviewed a cohort of septic patients with CVP ≥ 8 mmHg in a tertiary hospital intensive care unit. General characteristics and echocardiographic parameters including tricuspid annular plane systolic excursion (TAPSE), pulmonary vascular resistance (PVR) as well as prognostic data were collected. Associations between RV function parameters and 30-day mortality were assessed using Cox regression models.

Results

Echocardiography was performed in 244 septic patients with CVP ≥ 8 mmHg. Echocardiographic findings revealed that various types of abnormal RV function can occur individually or collectively. Prevalence of RV systolic dysfunction was 46%, prevalence of RV enlargement was 34%, and prevalence of PVR increase was 14%. In addition, we collected haemodynamic consequences and found that prevalence of systemic venous congestion was 16%, prevalence of RV-pulmonary artery decoupling was 34%, and prevalence of low cardiac index (CI) was 23%. The 30-day mortality of the enrolled population was 24.2%. In a Cox regression analysis, TAPSE (HR:0.542, 95% CI:0.302–0.972, p = 0.040) and PVR (HR:1.384, 95% CI:1.007–1.903, p = 0.045) were independently associated with 30-day mortality.

Conclusions

Echocardiographic findings demonstrated a high prevalence of RV-related abnormalities (RV enlargement, RV systolic dysfunction and PVR increase) in septic patients with elevated CVP. Among those echocardiographic parameters, TAPSE and PVR were independently associated with 30-day mortality in these patients.
Models to predict length of stay in the emergency department: a systematic literature review and appraisal
Authors: Farimani Raheleh Mahboub , Karim Hesam , Atashi Alireza , Tohidinezhad Fariba , Bahaadini Kambiz , Abu-Hanna Ameen , Eslami Saeid
Published: April 2024

Introduction

Prolonged Length of Stay (LOS) in ED (Emergency Department) has been associated with poor clinical outcomes. Prediction of ED LOS may help optimize resource utilization, clinical management, and benchmarking. This study aims to systematically review models for predicting ED LOS and to assess the reporting and methodological quality about these models.

Methods

The online database PubMed, Scopus, and Web of Science (10 Sep 2023) was searched for English language articles that reported prediction models of LOS in ED. Identified titles and abstracts were independently screened by two reviewers. All original papers describing either development (with or without internal validation) or external validation of a prediction model for LOS in ED were included.

Results

Of 12,193 uniquely identified articles, 34 studies were included (29 describe the development of new models and five describe the validation of existing models). Different statistical and machine learning methods were applied to the papers. On the 39-point reporting score and 11-point methodological quality score, the highest reporting scores for development and validation studies were 39 and 8, respectively.

Conclusion

Various studies on prediction models for ED LOS were published but they are fairly heterogeneous and suffer from methodological and reporting issues. Model development studies were associated with a poor to a fair level of methodological quality in terms of the predictor selection approach, the sample size, reproducibility of the results, missing imputation technique, and avoiding dichotomizing continuous variables. Moreover, it is recommended that future investigators use the confirmed checklist to improve the quality of reporting.
Brain volumes, behavioral inhibition, and anxiety disorders in children: results from the adolescent brain cognitive development study
Authors: Hammoud Rawan A. , Ammar Lara Abou , McCall Stephen J. , Shamseddeen Wael , Elbejjani Martine
Published: April 2024

Background

Magnetic resonance imaging (MRI) studies have identified brain changes associated with anxiety disorders (ADs), but the results remain mixed, particularly at a younger age. One key predictor of ADs is behavioral inhibition (BI), a childhood tendency for high avoidance of novel stimuli. This study aimed to evaluate the relationships between candidate brain regions, BI, and ADs among children using baseline data from the Adolescent Brain Cognitive Development (ABCD) study.

Methods

We analyzed global and regional brain volumes of 9,353 children (9–10 years old) in relation to BI and current ADs, using linear mixed models accounting for family clustering and important demographic and socioeconomic covariates. We further investigated whether and how past anxiety was related to brain volumes.

Results

Among included participants, 249 (2.66%) had a current AD. Larger total white matter (Beta = -0.152; 95% CI [-0.281, -0.023]), thalamus (Beta = -0.168; 95% CI [-0.291, -0.044]), and smaller hippocampus volumes (Beta = 0.094; 95% CI [-0.008, 0.196]) were associated with lower BI scores. Amygdala volume was not related to BI. Larger total cortical (OR = 0.751; 95% CI [0.580;0.970]), amygdala (OR = 0.798; 95%CI [0.666;0.956]), and precentral gyrus (OR = 0.802; 95% CI [0.661;0.973]) volumes were associated with lower odds of currently having ADs. Children with past ADs had smaller total white matter and amygdala volumes.

Conclusions

The results show associations between brain volumes and both BI and ADs at an early age. Importantly, results suggest that ADs and BI have different neurobiological correlates and that earlier occurrences of ADs may influence brain structures related to BI and ADs, motivating research that can better delineate the similarities and divergence in the neurobiological underpinnings and building blocks of BI and ADs across their development in early life.
Patient experience with bronchoscopy: topical versus monitored anesthesia
Authors: Huang Chun-Ta , Chou Rou-Jun , Hu Geng-Ning , Lee Tien-Cheng , Tsai Yi-Ju , Ho Chao-Chi
Published: April 2024

Background

This study aimed to compare patient experiences during bronchoscopy procedures using either topical anesthesia (TA) or monitored anesthesia care (MA). The goal was to identify circumstances where patients could achieve similar levels of tolerance and satisfaction using only TA, especially in resource-limited settings.

Methods

This study included consecutive patients who underwent bronchoscopy with either TA or MA. Data collected included demographics, indications for bronchoscopy, procedure time, and complications during the procedure. A quality assurance survey was administered to assess patient experience and satisfaction with both procedures. A pre-specified subgroup analysis was performed based on procedure invasiveness and time.

Results

This study enrolled 350 (TA 251; MA 99) patients, with an average age of 65 years. Main indications for bronchoscopy included tumor diagnosis (38%), esophageal cancer staging (18%), and pulmonary infection (17%). The average duration of the procedures was 20 min, with MA being associated with a significantly longer procedure time than TA (31 min vs. 16 min; P < 0.001). The overall satisfaction rating with bronchoscopy was significantly higher in the MA group (visual analogue scale, 8.9 vs. 8.2; P = 0.001). Subgroup analyses showed that when less invasive or shorter procedures were performed, TA patients reported tolerance and satisfaction levels comparable to MA patients.

Conclusions

Bronchoscopy with MA offered patients a better experience and greater satisfaction; however, in settings with limited resources, TA alone may provide similar levels of patient tolerance and satisfaction during less invasive or shorter procedures.
Surgical management of lower limb radiculopathy following acute singe-level osteoporotic vertebral fracture of lower lumbar spine in geriatric patient: a retrospective study
Authors: Zhang Yao , Lu Yuzheng , Lin Wancheng , Yao Mingtao , Song Jipeng , Ding Lixiang
Published: April 2024

Background

Radiculopathy of the lower limb after acute osteoporotic vertebral fractures (OVFs) in the lower lumbar spine is uncommon in geriatric patients. Moreover, surgical intervention is generally recommended in patients who are irresponsive to conservative treatment. Determining an optimum surgical strategy is challenging considering the poor general condition of this population. Thus, herein, we established an algorithm for surgically managing this clinical scenario, hoping to provide a reference for making a surgical decision.

Methods

We retrospectively studied patients who suffered from new-onset radiculopathy of the lower limb after acute single-level OVFs in the lower lumbar spine and eventually underwent surgical intervention at our department. Information on the demographics, bone quality, AO spine classification of the vertebral fracture, pre-existing degenerative changes, including foraminal stenosis and lumbar disc herniation, and surgical intervention type was collected. Additionally, clinical outcomes, including preoperative and postoperative visual analog scale (VAS) scores for back and leg pain, Oswestry disability index (ODI), and MacNab criterion for response to surgery, were evaluated.

Results

From September 2019 to December 2021, a total of 22 patients with a mean age of 68.59 ± 9.74 years were analyzed. The most involved vertebra was L5 (54.5%), followed by L4 (27.3%) and L3 (18.2%). Among the 22 patients, 15 (68.2%) were diagnosed with the A1 type fracture of AO classification, and among them, 11 (73.3%) were characterized by the collapse of the inferior end plate (IEP). Three patients (13.6%) suffered from A2-type fractures, whereas four patients (18.2%) suffered from A3-type fractures. Pre-existing degenerative changes were observed in 12 patients (54.5%) of the patients. A total of 16 patients (72.7%) were treated by percutaneous kyphoplasty (PKP). Additionally, three patients underwent posterior instrumentation and fusion, two patients underwent a secondary endoscopic foraminoplasty, and one patient underwent a secondary radiofrequency ablation. The mean follow-up period was 17.42 ± 9.62 months. The mean VAS scores for leg and back pain and ODI decreased significantly after the surgery (P < 0.05). The total satisfaction rate at the last follow-up was 90.9% per the Macnab criterion.

Conclusion

Patients with OVFs in the IEP are predisposed to suffer from radiculopathy of the lower limb. PKP alone or in combination with other minimally invasive surgical strategies is safe and effective in treating stable fractures. Additionally, aggressive surgical intervention should be considered in patients with unstable fractures or severe foraminal encroachment.
Cross-cultural adaptation and psychometric validation of point-of-care outcome assessment tools in Chinese palliative care clinical practice
Authors: Dai Yunyun , Johnson Claire E , Ding Jinfeng , Chen Yongyi , Connolly Alanna , Wang Lianjun , Daveson Barbara A
Published: April 2024

Background

A standardized national approach to routinely assessing palliative care patients helps improve patient outcomes. However, a quality improvement program-based on person centered outcomes within palliative care is lacking in Mainland China. The well-established Australian Palliative Care Outcome Collaboration (PCOC) national model improves palliative care quality. This study aimed to culturally adapt and validate three measures that form part of the PCOC program for palliative care clinical practice in China: The PCOC Symptom Assessment Scale (PCOC SAS), Palliative Care Problem Severity Scale (PCPSS), Palliative Care Phase.

Methods

A study was conducted on cross-cultural adaptation and validation of PCOC SAS, PCPSS and Palliative Care Phase, involving translation methods, cognitive interviewing, and psychometric testing through paired assessments.

Results

Cross-cultural adaptation highlighted the need to strengthen the link between the patient’s care plan and the outcome measures to improve outcomes, and the concept of distress in PCOC SAS. Analysis of 368 paired assessments (n = 135 inpatients, 22 clinicians) demonstrated that the PCOC SAS and PCPSS had good and acceptable coherence (Cronbach’s a = 0.85, 0.75 respectively). Palliative Care Phase detected patients’ urgent needs. PCOC SAS and PCPSS showed fair discriminant and concurrent validity. Inter-rater reliability was fair for Palliative Care Phase (k = 0.31) and PCPSS (k = 0.23–0.30), except for PCPSS-pain, which was moderate (k = 0.53).

Conclusions

The Chinese version of PCOC SAS, PCPSS, and Palliative Care Phase can be used to assess outcomes as part of routine clinical practice in Mainland China. Comprehensive clinical education regarding the assessment tools is necessary to help improve the inter-rater reliability.