bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Gonadotropin-Releasing Hormone (GnRH) in Endometrial Cancer
Authors: Emons Günter , Gründker Carsten
Published: February 2021

Endometrial cancer (EC) is one of the most common gynecological malignancies. Gonadotropin releasing hormone (GnRH) is a decapeptide first described to be secreted by the hypothalamus to regulate pituitary gonadotropin secretion. In this systematic review, we analyze and summarize the data indicating that most EC express GnRH and its receptor (GnRH-R) as part of an autocrine system regulating proliferation, the cell cycle, and apoptosis. We analyze the available data on the expression and function of GnRH-II, its putative receptor, and its signal transduction. GnRH-I and GnRH-II agonists, and antagonists as well as cytotoxic GnRH-I analogs, have been shown to inhibit proliferation and to induce apoptosis in human EC cell lines in pre-clinical models. Treatment with conventional doses of GnRH-agonists that suppress pituitary gonadotropin secretion and ovarian estrogen production has become part of fertility preserving therapy of early EC or its pre-cancer (atypical endometrial hyperplasia). Conventional doses of GnRH-agonists had marginal activity in advanced or recurrent EC. Higher doses or more potent analogs including GnRH-II antagonists have not yet been used clinically. The cytotoxic GnRH-analog Zoptarelin Doxorubicin has shown encouraging activity in a phase II trial in patients with advanced or recurrent EC, which expressed GnRH-R. In a phase III trial in patients with EC of unknown GnRH-R expression, the cytotoxic GnRH doxorubicin conjugate was not superior to free doxorubicin. Further well-designed clinical trials exploiting the GnRH-system in EC might be useful.
The SC-35 Splicing Factor Interacts with RNA Pol II and A-Type Lamin Depletion Weakens This Interaction
Authors: Legartová Soňa , Fagherazzi Paolo , Stixová Lenka , Kovařík Aleš , Raška Ivan , Bártová Eva
Published: February 2021

The essential components of splicing are the splicing factors accumulated in nuclear speckles; thus, we studied how DNA damaging agents and A-type lamin depletion affect the properties of these regions, positive on the SC-35 protein. We observed that inhibitor of PARP (poly (ADP-ribose) polymerase), and more pronouncedly inhibitors of RNA polymerases, caused DNA damage and increased the SC-35 protein level. Interestingly, nuclear blebs, induced by PARP inhibitor and observed in A-type lamin-depleted or senescent cells, were positive on both the SC-35 protein and another component of the spliceosome, SRRM2. In the interphase cell nuclei, SC-35 interacted with the phosphorylated form of RNAP II, which was A-type lamin-dependent. In mitotic cells, especially in telophase, the SC-35 protein formed a well-visible ring in the cytoplasmic fraction and colocalized with β-catenin, associated with the plasma membrane. The antibody against the SRRM2 protein showed that nuclear speckles are already established in the cytoplasm of the late telophase and at the stage of early cytokinesis. In addition, we observed the occurrence of splicing factors in the nuclear blebs and micronuclei, which are also sites of both transcription and splicing. This conclusion supports the fact that splicing proceeds transcriptionally. According to our data, this process is A-type lamin-dependent. Lamin depletion also reduces the interaction between SC-35 and β-catenin in mitotic cells.
Polymeric Bioinks for 3D Hepatic Printing
Authors: Sarkar Joyita , Kamble Swapnil C. , Kashikar Nilambari C.
Published: February 2021

Three-dimensional (3D) printing techniques have revolutionized the field of tissue engineering. This is especially favorable to construct intricate tissues such as liver, as 3D printing allows for the precise delivery of biomaterials, cells and bioactive molecules in complex geometries. Bioinks made of polymers, of both natural and synthetic origin, have been very beneficial to printing soft tissues such as liver. Using polymeric bioinks, 3D hepatic structures are printed with or without cells and biomolecules, and have been used for different tissue engineering applications. In this review, with the introduction to basic 3D printing techniques, we discuss different natural and synthetic polymers including decellularized matrices that have been employed for the 3D bioprinting of hepatic structures. Finally, we focus on recent advances in polymeric bioinks for 3D hepatic printing and their applications. The studies indicate that much work has been devoted to improvising the design, stability and longevity of the printed structures. Others focus on the printing of tissue engineered hepatic structures for applications in drug screening, regenerative medicine and disease models. More attention must now be diverted to developing personalized structures and stem cell differentiation to hepatic lineage.
Social and Technological Impact of Businesses Surrounding Electric Vehicles
Authors: Vidhi Rachana , Shrivastava Prasanna , Parikh Abhishek
Published: February 2021

Electric vehicle (EV) penetration has been increasing globally and is expected to continue its exponential growth over the coming decades. Several countries have already announced plans to achieve total or partial electrification of their vehicle fleets. Such rapid transportation electrification will have a significant impact on society and businesses that support the transportation industry. Additionally, new business opportunities will be available to support this technological evolution. In this paper, the business opportunities emerging from EVs and their supporting infrastructure are reviewed. It has been observed that several businesses, such as sustainable mining and manufacturing, will need to be developed before EV growth as they provide the initial platform required for EV adoption. Other businesses such as fleet optimization, battery management, and recycling can be developed at a later stage. All of these businesses will also have social and technological impacts, which will drive policy decisions. Regional governments play a critical role in ensuring the smooth execution of a transition to transportation electrification through social programs, such as training and education for equitable growth, and legislative decisions, such as technology standardization.
Pancreatic Carcinoma Metastatic to the Gingiva
Authors: Zubović Arijan , Belušić-Gobić Margita , Harmicar David , Marušić Jasna , Vučinić Damir , Zamolo Gordana
Published: February 2021

Metastatic tumors to the oral cavity are uncommon, representing approximately 1% of all cases of oral malignant lesions even when a metastatic disease is present. The 53-year-old female is presented complaining of abdominal pain, weight loss, and a loose stool recurring not more than three times per day. A computed tomography (CT) scan of the abdomen showed a retroperitoneal mass expanding along the body of the pancreas. Colonoscopy and gastroscopy with a gastric mucosa biopsy showed a normal result. After laparoscopic surgery, the primary site of adenocarcinoma was not confirmed. The patient was referred to the Maxillofacial Surgery Clinic with pain, swelling, and occasional bleeding around the lower right second mollar. Immunohistochemicaly, the tumor cells were positive for Cytokeratin (CK) 19, Cytokeratin (CK) 7, and homebox protein (CDX-2), which are highly sensitive markers of pancreatobiliar cancer. Therefore, the patient was diagnosed with pancreatic carcinoma. This report describes a rare metastasis of malignant pancreatic tumor to the lower right gingiva and highlights the importance of immunohistochemical examination and how it helped identify both the origin and the nature of gingival neoplasm.
Measurement of the Level of Nitric Oxide in Exhaled Air in Patients Using Acrylic Complete Dentures and with Oral Pathologies
Authors: Wyszyńska Magdalena , Czelakowska Aleksandra , Rój Rafał , Zając Magdalena , Mielnik Michał , Kasperski Jacek , Skucha-Nowak Małgorzata
Published: February 2021

The measurement of nitric oxide (NO) in exhaled air is used in diagnostics and monitoring of the pathologies in the respiratory system but also in the oral cavity. Researchers have shown a huge increase of its level in asthma and diseases in the oral cavity. It seems reasonable to research the impact of pathologies in the oral cavity on the level of NO in exhaled air. The purpose of this study was to determine the impact of inflammation in the oral cavity (according to the material of dentures) on the level of nitric oxide in exhaled air. Three groups of patients were examined in this study. The hygiene of acrylic dentures, hard tissues, periodontal tissues, hygiene of the oral cavity, and level of NO in exhaled air were examined. Prosthetic stomatitis, denture plaque, tooth decay, poor sanitation and periodontitis increase levels of NO.
Drying Oil and Natural Varnishes in Paintings: A Competition in the Metal Soap Formation
Authors: Poli Tommaso , Chiantore Oscar , Diana Eliano , Piccirillo Anna
Published: February 2021

Metal soaps formation is a well-known issue in oil paintings. Along the lifetime of the painting, carboxylic acids coming from drying oil (free fatty acids, acids from hydrolysis of triglycerides and from oxidation processes) can react with cations of some pigments (in particular, smalt, lead white and zinc white) forming the related carboxylic salts. As observed by many authors, the formation of these carboxylates, with the tendency to migrate and to aggregate, not only modifies the behavior and the aspect of the paint film but also complicates the cleaning approach. In previous works we have demonstrated that a similar pigment reactivity is possible even in presence of natural resins (such as colophony, dammar, mastic, etc) historically used as final varnishes on paintings. In this case, in the reactions the terpenic acids, among the main components of the resins, are involved. In this work, the carboxylates formation kinetics has been studied starting from two representative acids (palmitic and abietic) of painting oils and natural varnishes. Successively, the reactivity of the palmitic acid with the potassium abietate and of the abietic acid with the potassium palmitate has been verified. This investigation aims at clarifying in which way terpenic acids can be involved in the metal soaps reactivity confirming that also surface varnishes may play a significant role in the carboxylates formation and reactivity. It is important to keep in mind that a finishing varnish can be removed and reapplied many times during the lifetime of a painting, thus renewing the provision of reactive terpenic acids at the interface of the painted layers.
The Mitochondrial Genome of Nematodontous Moss Polytrichum commune and Analysis of Intergenic Repeats Distribution Among Bryophyta
Authors: Goryunov Denis V. , Sotnikova Evgeniia A. , Goryunova Svetlana V. , Kuznetsova Oxana I. , Logacheva Maria D. , Milyutina Irina A. , Fedorova Alina V. , Fedosov Vladimir E. , Troitsky Aleksey V.
Published: February 2021

An early-branched moss Polytrichum commune is a widely accepted model object for ecological, environmental, physiological, and genetic studies. Its mitochondrial genome has been sequenced and annotated. The genome contains 67 genes in total and has a length equal to 114,831 bp, which exceeds the length of most known mitochondrial genomes for mosses. A phylogenetic tree based on 33 coding sequences of mitochondrial genome was constructed, and the pairwise identity of whole mitogenome sequences was estimated for 44 Bryophyta species. Based on the analysis of pairwise identity, it was shown that mitogenomes of Tetraphis pellucida and Buxbaumia aphylla sufficiently differ from those of other Bryophyta species. The first known Bryophyta mitogenome rearrangement was identified in Pogonatum inflexum within Polytrichopsida. Based on the intergenic repeats occurrence in 44 bryophyte mitochondrial genomes and available data on repetitive elements content in other Viridiplantae groups, it was noted for the first time that greater stability of the moss’s mitogenomes is probably associated mainly with the absence of long (>1 kb) repeats. The phenomenon of absence of the intergenic repetitive elements in the terminal clades species was discovered.
Nerve Ultrasound as Helpful Tool in Polyneuropathies
Authors: Kramer Magdalena , Grimm Alexander , Winter Natalie , Dörner Marc , Grundmann-Hauser Kathrin , Stahl Jan-Hendrik , Wittlinger Julia , Kegele Josua , Kronlage Cornelius , Willikens Sophia
Published: February 2021

Background: Polyneuropathies (PNP) are a broad field of diseases affecting millions of people. While the symptoms presented are mostly similar, underlying causes are abundant. Thus, early identification of treatable causes is often difficult. Besides clinical data and basic laboratory findings, nerve conduction studies are crucial for etiological classification, yet limited. Besides Magnetic Resonance Imaging (MRI), high-resolution nerve ultrasound (HRUS) has become a noninvasive, fast, economic and available tool to help distinguish different types of nerve alterations in neuropathies. Methods: We aim to describe typical ultrasound findings in PNP and patterns of morphological changes in hereditary, immune-mediated, diabetic, metabolic and neurodegenerative PNP. Literature research was performed in PubMed using the terms ‘nerve ultrasound’, neuromuscular ultrasound, high-resolution nerve ultrasound, peripheral nerves, nerve enlargement, demyelinating, hereditary, polyneuropathies, hypertrophy’. Results: Plenty of studies over the past 20 years investigated the value of nerve ultrasound in different neuropathies. Next to nerve enlargement, patterns of nerve enlargement, echointensity, vascularization and elastography have been evaluated for diagnostic terms. Furthermore, different scores have been developed to distinguish different etiologies of PNP. Conclusions: Where morphological alterations of the nerves reflect underlying pathologies, early nerve ultrasound might enable a timely start of available treatment and also facilitate follow up of therapy success.
Molecular Profiling of Merkel Cell Polyomavirus-Associated Merkel Cell Carcinoma and Cutaneous Melanoma
Authors: Mokánszki Attila , Méhes Gábor , Csoma Szilvia Lilla , Kollár Sándor , Chang Chien Yi-Che
Published: February 2021

Merkel cell carcinoma (MCC) is a rare, high-grade, aggressive cutaneous neuroendocrine malignancy most commonly associated with sun-exposed areas of older individuals. A relatively newly identified human virus, the Merkel cell polyomavirus (MCPyV) has been implicated in the pathogenesis of MCC. Our study aimed to examine nine MCC cases and randomly selected 60 melanoma cases to identify MCPyV status and to elucidate genetic differences between virus-positive and -negative cases. Altogether, seven MCPyV-positive MCC samples and four melanoma samples were analyzed. In MCPyV-positive MCC RB1, TP53, FBXW7, CTNNB1, and HNF1A pathogenic variants were identified, while in virus-negative cases only benign variants were found. In MCPyV-positive melanoma cases, besides BRAF mutations the following genes were also affected: PIK3CA, STK11, CDKN2A, SMAD4, and APC. In contrast to studies found in the literature, a higher tumor burden was detected in virus-associated MCC compared to MCPyV-negative cases. No association was identified between virus infection and tumor burden in melanoma samples. We concluded that analyzing the key morphologic and immunohistological features of MCC is critical to avoid confusion with other cutaneous malignancies. Molecular genetic investigations such as next-generation sequencing (NGS) enable molecular stratification, which may have future clinical impact.
Fuzzy Control System for Smart Energy Management in Residential Buildings Based on Environmental Data
Authors: Kontogiannis Dimitrios , Bargiotas Dimitrios , Daskalopulu Aspassia
Published: February 2021

Modern energy automation solutions and demand response applications rely on load profiles to monitor and manage electricity consumption effectively. The introduction of smart control systems capable of handling additional fuzzy parameters, such as weather data, through machine learning methods, offers valuable insights in an attempt to adjust consumer behavior optimally. Following recent advances in the field of fuzzy control, this study presents the design and implementation of a fuzzy control system that processes environmental data in order to recommend minimum energy consumption values for a residential building. This system follows the forward chaining Mamdani approach and uses decision tree linearization for rule generation. Additionally, a hybrid feature selector is implemented based on XGBoost and decision tree metrics for feature importance. The proposed structure discovers and generates a small set of fuzzy rules that highlights the energy consumption behavior of the building based on time-series data of past operation. The response of the fuzzy system based on sample input data is presented, and the evaluation of its performance shows that the rule base generation is derived with improved accuracy. In addition, an overall smaller set of rules is generated, and the computation is faster compared to the baseline decision tree configuration.
Toward a Self-Powered Vibration Sensor: The Signal Processing Strategy
Authors: Andò Bruno , Baglio Salvatore , Bulsara Adi R. , Marletta Vincenzo
Published: February 2021

This paper, for the first time, investigates the possibility of exploiting a nonlinear bistable snap-through buckling structure employing piezoelectric transducers, to implement an autonomous sensor of mechanical vibrations, with an embedded energy harvesting functionality. The device is operated in the presence of noisy vibrations superimposed on a subthreshold deterministic (sinusoidal) input signal. While the capability of the device to harvest a significant amount of energy has been demonstrated in previous works, here, we focus on the signal processing methodology aimed to extract from the sensor output the information about the noise level (in terms of the standard deviation) and the root mean square amplitude of the deterministic component. The developed methodology, supported by experimental evidence, removes the contribution to the overall piezoelectric output voltage ascribable to the deterministic component using a thresholding and windowing algorithm. The contribution to the output voltage due to the noise can be used to unambiguously estimate the noise level. Moreover, an analytical model to estimate, from the measurement of the output voltage, the RMS amplitude of the deterministic input and the noise-related component is proposed.
Improvement of Transverse-Flux Machine Characteristics by Finding an Optimal Air-Gap Diameter and Coil Cross-Section at the Given Magneto-Motive Force of the PMs
Authors: Viktor Grebenikov , Dobzhanskyi Oleksandr , Rostislav Gamaliia , Gouws Rupert
Published: February 2021

This paper presents analysis and study of the single-phase transverse-flux machine. The finite element method results of the machine are compared with the laboratory measurements to confirm the accuracy of the computer model. This computer model is then used to investigate the effect of the machine’s geometry on its output characteristics. Parametric analysis of the machine is carried out to find the optimal air-gap diameter at which the cogging torque of the machine is minimal. In addition, the influence of the coil cross-section on the torque and output power characteristics of the machine is investigated and discussed.
Generic EMT Model for Real-Time Simulation of Large Disturbances in 2 GW Offshore HVAC-HVDC Renewable Energy Hubs
Authors: Ganesh Saran , Perilla Arcadio , Rueda Torres Jose , Palensky Peter , Lekić Aleksandra , van der Meijden Mart
Published: February 2021

This paper proposes a Electro-Magnetic Transient (EMT) model of a 2 GW offshore network with the parallel operation of two Modular Multi-level Converter (MMC)—High Voltage Direct Current (HVDC) transmission links connecting four Offshore Wind Farms (OWFs) to two onshore systems, which represent a large scale power system. Additionally, to mitigate the challenges corresponding to voltage and frequency stability issues in large scale offshore networks, a Direct Voltage Control (DVC) strategy is implemented for the Type-4 Wind Generators (WGs), which represent the OWFs in this work. The electrical power system is developed in the power system simulation software RSCADTM, that is suitable for performing EMT based simulations. The EMT model of 2 GW offshore network with DVC in Type-4 WGs is successfully designed and it is well-coordinated between the control structures in MMCs and WGs.
Multi-Objective Load Dispatch Control of Biomass Heat and Power Cogeneration Based on Economic Model Predictive Control
Authors: Li Lianming , He Defeng , Jin Jianrong , Yu Baoyun , Gao Xiang
Published: February 2021

This paper proposes a multi-objective load dispatch algorithm based on economic predictive control to solve the real-time multi-objective load dispatch problem of biomass heat and power cogeneration. According to the energy conservation law and production process, a real-time multi-objective load dispatch optimization model for heat and power units is established. Then, the concept of multi-objective utopia points is introduced, and the multi-objective load comprehensive objective function is defined to coordinate the conflict between the economic performance and pollutant emission performance of the units. Furthermore, using the online receding optimization characteristics of economic predictive control, the comprehensive objective function of multi-objective load dispatching is optimized online. Then, the fuel rate satisfying the economic performance and pollutant emission performance of the units is calculated to realize the economic performance and environmental protection operation of biomass heat and power cogeneration. Finally, the proposed multi-objective load dispatch control method is compared to traditional dispatch strategies by using industrial data. The results show that the method presented here can well balance the production cost and pollutant emission objective under the fluctuation of the thermoelectric load demand, and provides a feasible scheme for real-time dispatching of the multi-objective load dispatch problem of biomass heat and power cogeneration.
Large Eddy Simulations of Strongly Non-Ideal Compressible Flows through a Transonic Cascade
Authors: Hoarau Jean-Christophe , Cinnella Paola , Gloerfelt Xavier
Published: February 2021

Transonic flows of a molecularly complex organic fluid through a stator cascade were investigated by means of large eddy simulations (LESs). The selected configuration was considered as representative of the high-pressure stages of high-temperature Organic Rankine Cycle (ORC) axial turbines, which may exhibit significant non-ideal gas effects. A heavy fluorocarbon, perhydrophenanthrene (PP11), was selected as the working fluid to exacerbate deviations from the ideal flow behavior. The LESs were carried out at various operating conditions (pressure ratio and total conditions at inlet), and their influence on compressibility and viscous effects is discussed. The complex thermodynamic behavior of the fluid generates highly non-ideal shock systems at the blade trailing edge. These are shown to undergo complex interactions with the transitional viscous boundary layers and wakes, with an impact on the loss mechanisms and predicted loss coefficients compared to lower-fidelity models relying on the Reynolds-averaged Navier–Stokes (RANS) equations.
Responses of Soil Organic Carbon Mineralization and Microbial Communities to Leaf Litter Addition under Different Soil Layers
Authors: Zhang Min , Dong Li-Guo , Fei Shi-Xuan , Zhang Jia-Wen , Jiang Xu-Meng , Wang Ying , Yu Xuan
Published: February 2021

The mechanism of how soil carbon pools change when coniferous forests are converted into conifer-broadleaf mixed forests is poorly understood. In this study, the impact of additional carbon inputs on soil organic carbon mineralization and microbial communities was evaluated. In a microcosm incubation experiment, three types of 13C-labeled litter (Pinustabulaeformis (PT), Robiniapseudoacacia (RP), and a mixture of PT and RP (1:1, PR)) were added in to top (0–20 cm) and deep (60–80 cm) soil collected from a Chinese pine plantation. The priming effect (PE) and specific microbial groups involved in PE were studied. PT and RP addition to topsoil induced a negative PE. In deep soil, the decomposition rates of soil organic matter (SOM) after adding PT and mixture increased by 16.6% and 34.6% compared to those without litter. The addition of RP with a lower C:N ratio had a stronger negative PE than adding PT or mixture. Moreover, the PE in deep soil was more intense after all litter additions. In topsoil, the litter-derived carbon was mainly incorporated into 16:0, 18:1ω9c, and 18:1ω7c fatty acids. In conclusion, the addition of broadleaf litter into coniferous plantations might be beneficial for enhancing deep soil carbon stocks.
Partners in Infectious Disease: When Microbes Facilitate Enteric Viral Infections
Authors: Engevik Kristen A. , Engevik Melinda A.
Published: February 2021

The lumen of the gastrointestinal tract harbors a diverse community of microbes, fungi, archaea, and viruses. In addition to occupying the same enteric niche, recent evidence suggests that microbes and viruses can act synergistically and, in some cases, promote disease. In this review, we focus on the disease-promoting interactions of the gut microbiota and rotavirus, norovirus, poliovirus, reovirus, and astrovirus. Microbes and microbial compounds can directly interact with viruses, promote viral fitness, alter the glycan structure of viral adhesion sites, and influence the immune system, among other mechanisms. These interactions can directly and indirectly affect viral infection. By focusing on microbe–virus interplay, we hope to identify potential strategies for targeting offending microbes and minimizing viral infection.
Characterization and Comparative Analysis of Complete Mitogenomes of Three Cacatua Parrots (Psittaciformes: Cacatuidae)
Authors: Kim Jung-Il , Do Thinh Dinh , Choi Yisoo , Yeo Yonggu , Kim Chang-Bae
Published: February 2021

Cacatua alba, Cacatua galerita, and Cacatua goffiniana are parrots of the family Cacatuidae. Wild populations of these species are declining with C. alba listed by the International Union for the Conservation of Nature and Natural Resources (IUCN) as Endangered. In this study, complete mitogenomes were sequenced for a comparative analysis among the Cacatua species, and a detailed analysis of the control region. Mitogenome lengths of C. alba,C. galerita, and C. goffiniana were 18,894, 18,900, and 19,084 bp, respectively. They included 13 protein coding genes, two ribosomal RNA genes, 24 transfer RNA genes, three degenerated genes, and two control regions. Ten conserved motifs were found in three domains within each of the two control regions. For an evolution of duplicated control regions of Cacatua, domain I and the 3′ end of domain III experienced an independent evolution, while domain II and most of the regions of domain III was subjected to a concerted evolution. Based on a phylogenetic analysis of 37 mitochondrial genes, the genus Cacatua formed a well-supported, monophyletic, crown group within the Cacatuidae. Molecular dating results showed that Cacatua diverged from other genera of Cacatuinae in the middle of Miocene.
Self-Esteem, Attitudes toward Love, and Sexual Assertiveness among Pregnant Adolescents
Authors: Moyano Nieves , Granados Reina , Durán Christian Andrés , Galarza Carlos
Published: February 2021

Adolescence is a stage of growth and development of great relevance. Unplanned teenage pregnancies can be considered a global public health problem due to the high impact on the present and future of these young people, as well as their possible offspring. The aim of this study was to analyze the relationship between self-esteem, attitudes toward love, and sexual assertiveness among pregnant and non-pregnant teenagers. We also considered whether their pregnancy was planned or not. The study was conducted with 225 women from Ecuador (34.2% pregnant; Mean age = 16; SD = 1.15). We administered self-reported measures such as the Rosenberg Self-Esteem Scale, the Love Attitudes Scale, and the Sexual Assertiveness Scale between 2018 and 2019. Self-esteem was higher in adolescents with a planned pregnancy than in those women whose pregnancy was not planned. Pregnant women reported greater acceptance and endorsement of beliefs related to the myth of “soulmate” in comparison to non-pregnant women. Sexual assertiveness related to the negotiation of the use of contraceptive methods was greater in non-pregnant adolescents than in pregnant girls. We discuss the implications of our findings in terms of sexual education and prevention in the sex education field. This study shows differences in self-esteem, attitudes toward love, and sexual assertiveness between pregnant and non-pregnant adolescents.
The Economic Cost of Diet and Its Association with Adherence to the Mediterranean Diet in a Cohort of Spanish Primary Schoolchildren
Authors: Pastor Rosario , Pinilla Noemi , Tur Josep A.
Published: February 2021

Background: Adoption of a certain dietary pattern is determined by different factors such as taste, cost, convenience, and nutritional value of food. Objective: To assess the association between the daily cost of a diet and its overall quality in a cohort of 6–12-year-old Spanish schoolchildren. Methods: A cross-sectional survey was conducted on a cohort (n = 130; 47% female) of 6–12-year-old children schooled in primary education in the central region of Spain. Three-day 24 h records were administered, and the nutritional quality of the diet was also determined by means of Mediterranean Adequacy Index (MAI). A questionnaire on sociodemographic data, frequency of eating in fast-food restaurants, and supplement intake were also recorded. The person responsible for the child’s diet and the schooler himself completed the questionnaires, and homemade measures were used to estimate the size of the portions. Food prices were obtained from the Household Consumption Database of the Spanish Ministry of Agriculture, Fisheries and Food. The economic cost of the diet was calculated by multiplying the amount in grams of the food consumed by each child by the corresponding price in grams and adding up the total amount for each participant. The total economic cost of the diet was calculated in €/day and in €/1000 kcal/day. Results: The area under the curve (AUC) for €/day and €/1000 kcal/day represent 62.6% and 65.6%, respectively. According to AUC values, adherence to Mediterranean diet (MD) is a moderate predictor of the monetary cost of the diet. A direct relationship between the cost of the diet and the adherence to MD was observed [OR (€/1000 kcal/day) = 3.012; CI (95%): 1.291; 7.026; p = 0.011]. Conclusions: In a cohort of Spanish schoolchildren with low adherence to the MD, a higher cost of the diet standardized to 1000 kcal was associated with above-average MAI values.
Relationship between Fixed Dental Crowns and Volatile Sulphur Compounds
Authors: Alzoman Hamad , Rashid Habib Syed , Alghamdi Sultan , Al-Juhani Hebah , Daabash Rawan , Al-Khalid Wijdan , Al-Askar Mansour , Al-Johany Sulieman
Published: February 2021

Objectives: The aim of this study was to investigate and compare the level of halitosis in patients with/without fixed crowns and in addition the influence of various crown parameters on halitosis was also explored. Methods: In total, 96 subjects (fixed crowns = 52; no crowns = 44) participated in the study. The levels volatile sulphur compounds (VSCs) of hydrogen sulphide (H2S), methyl mercaptan (CH3SH), and dimethyl sulphide (CH3SCH3) were evaluated with breath samples using gas chromatography and used for classification as presence or absence of halitosis. The periodontal clinical parameters for all the participants as well as the crown parameters for participants with fixed crowns were also evaluated. Cross tabulation, Chi-square test, and one-way analysis of variance tests were used for the statistical analysis and comparisons. Results: Breath samples revealed, 50 (52.1%) participants were suffering from halitosis. Out of VSCs, the level of CH3SCH3 (62.5%) was found to be the most prevalent. Significant correlations were observed between the presence of fixed crowns and oral halitosis (p < 0.001). Statistically significant difference in the concentration of H2S and CH3SH (p < 0.001) and no significance for CH3SCH3 (p = 0.075) between patients with/without fixed crowns was found. The presence of halitosis was more prevalent in the subjects with crown parameters (subgingival margin, over-contoured margin, open-crown margin, over-contoured and under-contoured crowns) considered clinically defective/unacceptable (p < 0.05). Conclusions: Presence of fixed dental crowns significantly contributes to the oral halitosis. Dental crowns with defects significantly impair the hygienic conditions and oral microflora resulting in high prevalence of halitosis.
Exercise-Induced Release of Cardiac Troponins in Adolescent vs. Adult Swimmers
Authors: Cirer-Sastre Rafel , Corbi Francisco , López-Laval Isaac , Carranza-García Luis Enrique , Reverter-Masià Joaquín
Published: February 2021

To examine the exercise-induced release of cardiac troponin T (cTnT) in adolescent and adult swimmers. Thirty-two trained male (18 adolescents, 14 adults) swam at maximal pace in a 45 min distance trial, and blood samples were drawn before, immediately and 3 h after exercise for subsequent cTnT analysis and comparison. Having comparable training experience and baseline values of cTnT (p = 0.78 and p = 0.13), adults exercised at lower absolute and relative intensity (p < 0.001 and p < 0.001, respectively), but presented higher immediate cTnT after exercise than adolescents (p < 0.001). Despite that, peak concentrations were observed at 3 h post exercise and peak elevations were comparable between groups (p = 0.074). Fourteen (44%) apparently healthy subjects exceeded the cutoff value for myocardial infarction (MI). Adolescents presented a delayed elevation of cTnT compared with adults, but achieved similar peak values.
Assessing Comfort in Urban Public Spaces: A Structural Equation Model Involving Environmental Attitude and Perception
Authors: Peng You , Peng Zhikai , Feng Tao , Zhong Chixing , Wang Wei
Published: February 2021

The research of comfort in urban public spaces has become increasingly important for improving environmental quality and encouraging people spend more time in outdoor activities. Among numerous approaches to understand comfort perception, the rational indices based on heat balance theory have prevailed to guide the research and practice in urban planning, design, and management. The limitations of a solely rational index-based approach reveal the necessity for a more comprehensive understanding of comfort by considering a wider range of influential factors from both individual and environmental perspectives during the assessing process. This study conceptualizes individuals’ comfort in urban public spaces as a latent construct, which is measured by indicators regarding perceptions on multifarious meteorological variables. The conceptual framework has been introduced involving hypothetical relationships among individuals’ comfort, attitudes, and environmental perceptions in urban public spaces. A series of field work including microclimate measurements and questionnaire-based surveys were carried out in two public squares in Changsha, China. Based on the dataset derived from 372 questionnaires and related meteorological measurements, this paper examines the relationships between the physical microclimatic variables, individuals’ socio-demographical characteristics and environmental attitudes and perceptions, and outdoor comfort assessment. The estimation results of the structural equation model quantitatively verified the conceptual framework at large, as many hypothetical relationships are identified, which indicates the importance of individuals’ role and the psychological factors in modeling comfort perception. This approach improves the understanding of comfort assessment, contributes to improving the quality of urban environment and the practices of urban planning and management.
Association between Physical Activity and Fundamental Movement Skills in Preschool-Aged Children: Does Perceived Movement Skill Competence Mediate This Relationship?
Authors: He Qing , Ng Johan Y. Y. , Cairney John , Bedard Chloe , Ha Amy S. C.
Published: February 2021

Objectives: The purpose of this research is to examine whether perceived fundamental movement skills (FMS) competence mediated the relationship between actual FMS and physical activity (PA) in Hong Kong preschool-aged children. Design: A cross−sectional study. Methods: 148 preschool-aged children (43% girls; mean age = 4.52 ± 0.67 years) from five preschools/childcare centres completed all assessments. Actual FMS was rated using the Test of Gross Motor Development−2, whilst perceived FMS was assessed via the Pictorial Scale for Perceived Movement Skill Competence. PA was measured through accelerometry. A bootstrap method was used to assess the potential mediating effect of perceived movement skill competence on the relationship between actual FMS and PA. All mediation models were adjusted for sex and age. Results: Mediation analyses showed that the direct path between actual FMS and moderate-to-vigorous physical activity (MVPA) was significant (b = 0.228, p = 0.008), as was the path between MVPA and actual FMS (b = 0.214, p = 0.008). However, perceived FMS competence did not mediate the association between actual FMS and MVPA in the models. Conclusions: Our results showed evidence of reciprocal pathways between actual FMS and MVPA, reinforcing the need to simultaneously target both domains as part of broader developmental strategies, initiated in early childhood. Unlike emergent adolescence, perceptions of movement skill competence do not play a significant role in influencing the relationship between actual FMS proficiency and MVPA in this developmental period.
“Just Be Strong, You Will Get through It” a Qualitative Study of Young Migrants’ Experiences of Settling in New Zealand
Authors: De Jacolyn Enoka , Stasiak Karolina , McCool Judith
Published: February 2021

Migration, when it occurs during adolescence, is particularly challenging as it coincides with a myriad of other developmental and social changes. The present study set out to explore recent young migrants’ experiences of settling in New Zealand. The qualitative study aimed to identify areas of particular challenge, examples of resilience and new insights into the acculturation process. Focus group interviews were conducted with migrant youth aged 16–19 from three urban secondary schools in Auckland The interviews were audio-recorded, transcribed and analyzed using a general inductive method. Key themes centered on new beginnings, confronting new realities, acceptance, support seeking and overcoming challenges. Young migrants in this study shared similar challenges during the early post-migration period. They were often faced with additional responsibility, being caught between two cultures while struggling with communication and language. However, they were able to draw on their own self-growth, gratitude, and social connections. This study provides an insight into experiences of young migrants in New Zealand, and offers suggestions for developing culturally relevant support to foster migrant youth wellbeing.
Global Population Exposed to Extreme Events in the 150 Most Populated Cities of the World: Implications for Public Health
Authors: Li Linze , Jiang Chengsheng , Murtugudde Raghu , Liang Xin-Zhong , Sapkota Amir
Published: February 2021

Climate change driven increases in the frequency of extreme heat events (EHE) and extreme precipitation events (EPE) are contributing to both infectious and non-infectious disease burden, particularly in urban city centers. While the share of urban populations continues to grow, a comprehensive assessment of populations impacted by these threats is lacking. Using data from weather stations, climate models, and urban population growth during 1980–2017, here, we show that the concurrent rise in the frequency of EHE, EPE, and urban populations has resulted in over 500% increases in individuals exposed to EHE and EPE in the 150 most populated cities of the world. Since most of the population increases over the next several decades are projected to take place in city centers within low- and middle-income countries, skillful early warnings and community specific response strategies are urgently needed to minimize public health impacts and associated costs to the global economy.
Transforming the Future Healthcare Workforce across Europe through Improvement Science Training: A Qualitative Approach
Authors: Sierras-Davo Maria Cristina , Lillo-Crespo Manuel , Verdu Patricia , Karapostoli Aimilia
Published: February 2021

Healthcare improvement science (HIS) is the generation of knowledge to cultivate change towards improving health systems performance. Our purpose was to evaluate the experience of European nursing students after an intensive one-week summer program conducted in 2019 at the University of Alicante in Spain. The educational intervention combined theoretical and practical HIS contents, with students from different countries, educational programs, and health systems. The intervention was evaluated under a qualitative approach through the open discussion group technique based on the method of participatory action research (PAR), with a total of 25 students who reflected about their experiences and perceptions during the intervention. The responses were used to improve the program’s contents, its didactics, and organization. Nursing empowerment, professional recognition, and healthcare research were some of the seven main categories identified through the systematic content analysis method triangulated by three experienced researchers. According to the students’ replies, values like compassion, respect, or empathy were identified as key elements of care. Promoting international students’ networking emerged as the key to creating a positive provision for change and the generation of improvement initiatives. Building a HIS culture may potentially provide future healthcare professionals with critical thinking skills and the resources needed to improve their future work settings.
Student-Led Motivational Interviewing for Physical Activity Promotion among Rural Adults: A Feasibility and Acceptability Trial
Authors: Dziano Jenelle , Milanese Emma , Bogomolova Svetlana , Dollman James
Published: February 2021

In many countries, rural residents have lower life expectancies and poorer health outcomes than urban residents. Adults living in rural Australia have lower physical activity levels than major city counterparts, contributing to this observed health disparity. As physical activity interventions in rural populations have shown minimal success, there is an urgent need for innovative and affordable interventions that facilitate active lifestyles in this vulnerable population. This study assessed the feasibility of physical activity-focused motivational interviewing, delivered by university health sciences undergraduates in a rural Australian region. “Health age” was assessed at baseline (n = 62) from physiological and behavioral measures, immediately followed by the motivational interview, with health age again assessed at 8 weeks follow-up. Mixed methods using a questionnaire (n = 41 at both time points) and one-on-one interview (n = 8) identified aspects of intervention acceptability and feasibility. A large majority rated the motivational interview as meaningful (98%), empathetic (96%), autonomy-focused (88%), and likely to lead to sustained behavior change (98%). Interviews highlighted several potential attitudinal and structural factors that might influence long-term behavior change. Further development of this strategy in rural regions will depend on a deeper understanding of individuals’ and communities’ awareness, attitudes, and beliefs in relation to active lifestyles.
Improvement of Workplace Environment That Affects Motivation of Japanese Dental Hygienists
Authors: Yamamoto Yuko , Nomura Yoshiaki , Okada Ayako , Kakuta Erika , Yoshida Naomi , Hosoya Noriyasu , Hanada Nobuhiro , Takei Noriko
Published: February 2021

Dental hygienists are in high demand due to insufficient workforce and a lack of an effective reinstatement support system. We investigated the reasons for willingness to work by analyzing the survey results of the employment status of Japanese dental hygienists conducted by Japan Dental Hygienists’ Association. In total, we mailed 16,113 questionnaires to all members of the association (response rate 53.4%). We carried out statistical analysis to determine the specific items to improve the hygienists’ working environment. Fourteen factors of working conditions that they wish to improve were determined. Structural equation modeling showed that a path, “Reduction of work volume”, “Reduction of working hours” and “Increased number of holidays” were higher than other items. A decision analysis demonstrated that most of the respondents answered “Yes” to “Improvement in working conditions including higher salary” out of those who answered, “Strongly disagree” for “Do you feel that dental hygienist work is rewarding?”. Improving workplace environment is integral to keeping high levels of work motivation and a low turnover rate. Most of the hygienists wish for a salary raise among all the conditions. The transition from conventional work styles to non-conventional flexible working patterns is needed.
Pure-Tone Hearing Thresholds and Otoacoustic Emissions in Students of Music Academies
Authors: Pawlaczyk-Łuszczyńska Małgorzata , Zamojska-Daniszewska Małgorzata , Dudarewicz Adam , Zaborowski Kamil
Published: February 2021

The objective of this study was to assess the hearing of music students in relation to their exposure to excessive sounds. A standard pure-tone audiometry, transient-evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) were determined in 163 students of music academies, aged 22.8 ± 2.6 years. A questionnaire survey and sound pressure level measurements during solo and group playing were also conducted. The control group comprised 67 subjects, mainly non-music students, aged 22.8 ± 3.3 years. Study subjects were exposed to sounds at the A-weighted weekly noise exposure level (LEX,w) from 75 to 106 dB. There were no significant differences in the hearing thresholds between groups in the frequency range of 4000–8000 Hz. However, music students compared to control group exhibited lower values of DPOAE amplitude (at 6000 and 7984 Hz) and signal-to-noise ratio (SNR) (at 984, 6000, and 7984 Hz) as well as SNR of TEOAE (in 1000 Hz band). A significant impact of noise exposure level, type of instrument, and gender on some parameters of measured otoacoustic emissions was observed. In particular, music students having LEX,w ≥ 84.9 dB, compared to those with LEX,w < 84.9 dB, achieved significantly lower DPOAE amplitude at 3984 Hz. Meanwhile, both TEOAE and DPOAE results indicated worse hearing in students playing percussion instruments vs. wind instruments, and wind instrument players vs. students playing stringed instruments.