bluuebunny/crossref_metadata_2025 huggingface dataset:
Tunneling dynamics of spin-orbit coupled BECs in a one-dimensional accelerating optical lattice
Authors: Ma Yun-E , Qiao Xin , Gao Rui , Zhang Ai-Xia , Xue Ju-Kui
Published: December 2022

We theoretically investigate the energy band structure, nonlinear Landau–Zener tunneling dynamics and tunneling probability of spin-orbit coupled Bose–Einstein condensates in a one-dimensional accelerating optical lattice by using mean-field and two-mode approximation. The critical condition for the appearance of the loop structure is obtained numerically in parameter planes. When the intraspecies atomic interaction is less than the interspecies atomic interaction, the loop only appears in the lower band. In this case, Raman coupling inhibits the appearance of loop, while spin-orbit coupling (SOC) promotes the appearance of loop. If the intraspecies atomic interaction is larger than interspecies atomic interaction, the loop can appear in either the upper band or the lower band. In this case, Raman coupling promotes the loop appearing in the lower band, while SOC suppresses the loop appearing in upper band. Interestingly, when the interspecies atomic interaction is equal to the intraspecies atomic interaction, there is a critical atomic intercation value determined by the optical lattice depth, only when the intraspecies atomic interaction is greater than the critical value, the loop will occur only in lower band. Especially, the emergence of the loop structure destroys the Bloch oscillation of the system and results in the nonlinear Landau–Zener tunneling of the system. Furthermore, the Landau–Zener tunneling probability of the system is calculated, and it is found that the nonlinear Landau–Zener dynamics and the tunneling probability can be manipulated by SOC and Raman coupling.
ACCOUNTING NOISE AND THE PRICING OF CoCos
Authors: DERKSEN MIKE , SPREIJ PETER , WIJNBERGEN SWEDER VAN
Published: December 2022

Contingent Convertible bonds (CoCos) convert into equity or are written down in times of distress. Existing pricing models assume conversion triggers based on market prices assuming that markets observe all relevant information. We incorporate that markets receive information through noisy accounting reports only, distinguish between market and accounting values and incorporate that coupon payments are subject to a Maximum Distributable Amount limit. We examine the impact of CoCo design and accounting noise on prices. Most importantly, we discuss the capital structure decision, explain why nondilutive CoCos tend to be chosen and how these increase the bank’s risk-taking incentives.
Principled Schedulability Analysis for Distributed Storage Systems Using Thread Architecture Models
Authors: Yang Suli , Liu Jing , Arpaci-Dusseau Andrea , Arpaci-Dusseau Remzi
Published: December 2022

In this article, we present an approach to systematically examine the
schedulability
of distributed storage systems, identify their scheduling problems, and enable effective scheduling in these systems. We use
Thread Architecture Models (TAMs)
to describe the behavior and interactions of different threads in a system, and show both how to construct TAMs for existing systems and utilize TAMs to identify critical scheduling problems. We specify three schedulability conditions that a schedulable TAM should satisfy: completeness, local enforceability, and independence; meeting these conditions enables a system to easily support different scheduling policies. We identify five common problems that prevent a system from satisfying the schedulability conditions, and show that these problems arise in existing systems such as HBase, Cassandra, MongoDB, and Riak, making it difficult or impossible to realize various scheduling disciplines. We demonstrate how to address these schedulability problems using both direct and indirect solutions, with different trade-offs. To show how to apply our approach to enable scheduling in realistic systems, we develop Tamed-HBase and Muzzled-HBase, sets of modifications to HBase that can realize the desired scheduling disciplines, including fairness and priority scheduling, even when presented with challenging workloads.
Permeability Characterization and Its Correlation with Pore Microstructure of Stress-Sensitive Tight Sandstone: Take Chang 6 in Ordos Basin for Example
Authors: Chang Yilin , Yang Zhengming , Zhang Yapu , Niu Zhongkun , Chen Xinliang
Published: December 2022

Tight reservoirs are sensitive to stress changes during fracturing and oil and gas production. Facing different production modes, the variation characteristics of rock permeability and pore structure need to be further clarified. In this study, using a self-built high temperature and pressure physical simulation device and NMR equipment, the influence of the stress loading method, cyclic loading, and loading rate on rock permeability and pore characteristics were analyzed, and the relationship between them was clarified. The permeability sensitivity under variable confining pressure (63.3%) was greater than that of variable flow pressure (46.4%). The damage rate decreased with repeated loading (63.3%-35.8%) and increased loading rate (53.1%-42.3%). As for the pore features, when the net stress increased, the volume variation range of micropores was greater than that of mesopores. The damage rate of permeability (63.3%) was obviously larger than that of pore volume (10.4%). The slope of the fitted curve of permeability and pore volume decreased evidently with loading times. The structure deformation of rock skeleton and the migration of cement had a great influence on permeability in the first loading. Later, it was mainly the bulk deformation of rock particles, the particles’ contact surface increasing and the seepage space shrinking slowly. Eventually, the permeability remained stable due to the limited pore compression. This study can provide a reference for designing reasonable production parameters and reducing formation damage.
An Efficient Algorithm to Enhance Nonoverlapping Coverage Area with Less Energy Consumption in WSN
Authors: Mufti Muhammad Rafiq , Awan Aqeel , Afzal Humaira , Malik Tauqeer Safdar , Gill Humera Batool
Published: December 2022

Several chargeable sensor nodes are deployed randomly to cover the target points with an efficient heuristic approach for the mobility of sensor nodes in an area of interest (AoI). The heuristic approach generates the cover set that includes the targets for a prolonged time. The cover sets are the subset of the total sensor node area where each set is capable of representing all the targets. The functionality of the sensor nodes depends upon the network lifetime of the target points covering an AoI. The network lifetime would improve by reducing the consumption of battery power through heuristic process. The proposed heuristic process can do this by generating cover sets and selecting sensor nodes with the highest remaining battery power. These cover sets remove the redundant sensor node in an AoI that causes the overlapping issue and assign the maximum lifetime which is the minimum amount of battery power of the sensor node, participating in the cover set. The results show the improvement in the mobility of sensor nodes by coverage and attain maximum network lifetime as compared to the existing algorithms.
Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking
Authors: Song Hanbing , Liu Hongpeng , Li Xiaodong , Lv Bing , Tang Zonghan , Chen Qipeng , Zhang Danqi , Wang Fei
Published: December 2022

Background. Marmesine, a major active ingredient isolated from Radix Angelicae biseratae (Duhuo), has been reported to have multiple pharmacological activities. However, its therapeutic effects against knee osteoarthritis (OA) remain poorly investigated. The present study is aimed at uncovering the core targets and signaling pathways of marmesine against osteoarthritis using a combined method of bioinformatics and network pharmacology. Methods. We utilized SwissTargetPrediction and PharmMapper to collect the potential targets of marmesine. OA-related differentially expressed genes (DEGs) were identified from GSE98918 dataset. Then, the intersection genes between DEGs and candidate genes of marmesine were subjected to protein-protein interaction (PPI) network construction and functional enrichment analysis. The core targets were verified using the molecular docking technology. Results. A total of 320 marmesine-related genes and 5649 DEGs and 60 ingredient-disease targets between them were identified. The results of functional enrichment analyses revealed that response to oxygen levels, neuroinflammatory response, PI3K-Akt signaling pathway, MAPK signaling pathway, FoxO signaling pathway, and osteoclast differentiation was identified as the potential mechanisms of marmesine against OA. EGFR, CASP3, MMP9, PPARG, and MAPK1 served as hub genes regulated by marmesine in the treatment of OA, and the molecular docking further verified the results. Conclusion. Marmesine exerts the therapeutic effects against OA through multitarget and multipathways, in which EGFR, CASP3, MMP9, PPARG, and MAPK1 might be hub genes. Our research indicated that the combination of bioinformatics and network pharmacology could serve as an effective approach for investigating the potential mechanisms of natural product.
Hölderlin e a questão da escrita em formas métricas antigas: aspectos de sua tradução no Brasil
Authors: Serpa Danilo
Published: December 2022

Após uma breve apresentação de Hölderlin e de sua poesia, o texto examina traduções de seus poemas no Brasil, considerando as formas métricas, dada a significância que certos metros têm para a caracterização de gêneros líricos, odes e elegias, praticados pelo autor, determinantes para sua compreensão. A análise leva em conta as diferenças no sistema de versificação (al. Verssysteme) (KAYSER 1964: 82-85) nas línguas de partida e de chegada, bem como reflexões e práticas tradutórias concebidas no Brasil no âmbito dos estudos clássicos, em que se lida, por sua vez, com outro sistema de versificação, diverso tanto do que é utilizado em língua portuguesa quanto alemã. Em especial desempenham papel reflexões de J. A. OLIVA NETO (2017; 2020) e a proposta de estabelecimento de equivalências entre formas, no que diz respeito ao metro da tradução e obra a ser traduzida. A escolha das traduções para a análise baseou-se em sua circulação e na apresentação de poemas em conjunto, o que foi considerado importante para a percepção de recorrências entre eles. Como resultado, correspondências sistemáticas na metrificação não puderam ser encontradas nas traduções analisadas. Porém, percebem-se nelas, de modo geral, possibilidades para um tal procedimento, delineadas de maneira incipiente.
A crença de que a felicidade de todos os seres humanos é possível: escrita, empatia e expansão dos direitos em Die Bürgerpflicht der Frau (1894 -1895) de Lily Braun
Authors: Decca Mauro Guzzo de
Published: December 2022

O presente artigo é uma análise do texto Die Bürgerpflicht der Frau (1895), da escritora alemã Lily Braun. O texto é um marco na história do movimento de mulheres alemão e oferece importantes subsídios para a reflexão sobre as contradições e tensões que marcam o pensamento e a atuação de Lily Braun. No artigo, ofereço um breve resumo da vida e obra da autora, apresento os contornos gerais do texto e procuro situá-lo em seu contexto histórico-social. Levanto a hipótese de que o movimento geral do texto de Lily Braun se explica como uma tentativa de expandir a esfera da empatia e o arco dos direitos para incluir segmentos da sociedade – como as mulheres e a classe trabalhadora mais pobre – então largamente excluídos. Essa tentativa deixa uma série de características textuais que procuro analisar em profundidade. Argumento ainda que o utilitarismo clássico milliano pode ter fornecido a Lily Braun uma base ético-filosófica para articular o seu esforço de mobilizar a empatia do público. Por fim, argumento que o texto nos permite refletir sobre as relações entre narrativa e empatia, e que o parâmetro textual do público exerce um papel mediador entre essas duas esferas.
Validação concorrente da OMNI para avaliação de percepção de esforço em adolescentes com espinha bífida
Authors: Mattiello-Sverzut Ana Claudia , Leonardi-Figueiredo Marisa Maia , Davoli Gabriela Barroso de Queiroz , Cruz Karoliny Lisandra Teixeira , Bertapelli Fabio
Published: December 2022

A avaliação da percepção de esforço (PE) é fundamental para auxiliar no monitoramento de intensidade e prescrição de atividades físicas em jovens com deficiências. Um método comumente usado para estimar a PE inclui a escala OMNI para ciclismo e OMNI adaptada para ergometria de braço.
Desafios da reabilitação em fibrodisplasia ossificante progressiva: relato de caso
Authors: Costa Thadeu Rocha da , Helfenstein Thomas , Oliveira Ana Alice Amaral
Published: December 2022

A Fibrodisplasia Ossificante Progressiva (FOP) acarreta limitação gradual da amplitude de movimento articular pela osteogênese heterotópica progressiva em diversas estruturas do tecido conjuntivo como músculos, fáscias, ligamentos e tendões.
Neuropatia motora multifocal um desafio diagnóstico
Authors: Hora João Sergio Ignacio , Rangel Ivan Orlando Castellanos , Vega Maria Patrícia Guerra , Rodas Patrícia Alexandra Viteri , Pinheiro Guilherme de Lima
Published: December 2022

Neuropatia motora multifocal (NMM), doença crônica inflamatória, desmielinizante, incapacitante, de baixa prevalência.
Desenvolvimento de displasia do quadril em crianças com síndrome congênita pelo Zika vírus
Authors: Lucca Vinícius Imakawa de , Magalhães Andréa Fernandes , Caldas Carla Andrea Tanuri
Published: December 2022

A síndrome congênita pelo Zika vírus (SCZ) envolve várias características clínicas secundárias à perda importante do volume intracraniano e danos neurológicos associados.
Os benefícios do marca-passo diafragmático em relação ao desmame da ventilação mecânica, técnica e resultado
Authors: Simões Luana Suely Barbosa
Published: December 2022

Apresentamos aqui os benefícios da implantação de um Marca-Passo Diafragmático (MPD) como opção de tratamento a pacientes que apresentam como condição clínica lesão medular cervical alta e que até então dependem de ventilação mecânica (VM).
Terapia por ondas de choque no tratamento da Síndrome da Disfunção Miofascial: qual melhor protocolo?
Authors: Costa Junior Carlos Antonio da , Braun Wellington Luiz Fagundes
Published: December 2022

Síndrome da disfunção miofascial (SDM) é uma síndrome musculoesquelética caracterizada por rigidez muscular, dor típica, surgimento de bandas tensas intramusculares, “twitch response” local e hiper-reatividade muscular.
Five new Brazilian species of Fuminana Freytag (Hemiptera: Cicadellidae: Gyponini) with new records and key to males
Authors: DOMAHOVSKI ALEXANDRE CRUZ , CAVICHIOLI RODNEY RAMIRO
Published: December 2022

Five new Brazilian species of Fuminana Freytag, 1989 are described and illustrated: F. diaphana sp. nov. from states of Maranhão and Piauí, F. guaricica sp. nov. from Paraná State, F. incurvata sp. nov. and F. retorta sp. nov. from Rondônia State, and F. niluga sp. nov. from states of Acre, Pará, Rondônia and Mato Grosso. The female genitalia is described and illustrated for the first time and a revised genus description is presented. New distribution records are given and seven species are newly recorded from Brazil: F. astra (DeLong & Freytag, 1969), F. conspicua (DeLong & Freytag, 1969), Fuminana curra (DeLong & Freytag, 1969), F. extata Freytag, 1989, F. jaculum (DeLong & Freytag, 1969), F. signa (DeLong & Freytag, 1969) and F. superba (DeLong & Freytag, 1969). A key to males is provided as well as some taxonomic notes about the genus.
Revisiting the Baroclinic Eddy Scalings in Two-Layer, Quasigeostrophic Turbulence: Effects of Partial Barotropization
Authors: Chen Shih-Nan
Published: December 2022

In this study, modifications of the Held scaling (Held) are proposed and tested against simulations of f-plane, two-layer quasigeostrophic turbulence. The aim is to better constrain the eddy mixing length and rms barotropic velocity in response to varied quadratic and linear bottom drag. The proposed modifications allow eddies to be partially barotropized, to relax the commonly invoked barotropization approximation, and consider a drag-dependent cascade rate per energy input, to account for the lack of an inertial range. Quantitative comparisons with the vortex gas scaling are also carried out. It is shown that the progressively weakened sensitivity in eddy scales to increased drag strength is mainly a result of eddy partial barotropization. For both drag forms except toward the limit of weak linear drag, accounting for partial barotropization alone leads to good predictions of eddy velocity, although not of mixing length. It also partly resolves the degeneracy of balance constraints for linear drag because partial barotropization acts like scale-dependent damping. Adding a cascade correction, which is interpreted as allowing for changes in spectral room for cascade, further improves the mixing length representation. Overall, the proposed theory can augment the existing scalings by extending the eddy scale predictions to O(1) quadratic drag and has skills generally comparable to the vortex gas scaling for linear drag. However, toward the weak linear drag limit where eddies approach complete barotropization, the proposed theory breaks down but the vortex gas performs well. Potential issues concerning the applicability of vortex gas to this limit are discussed.
Stochastic Ordering Inequalities in Parallel and Series Systems with Gumble Distributed Components
Authors: Biswas Surojit , Gupta Nitin
Published: December 2022

The stochastic comparisons of parallel and series systems are worthy of study. In this article, we present some stochastic comparisons of parallel and series systems having independent components from Gumble distribution which is also known as an extreme value type-I distribution with two parameters (one location and one shape). This study only deals with the location parameter. Here, we first put a condition for the likelihood ratio ordering of the parallel systems and second, we use the concept of vector majorization technique to compare the systems by the reversed failure rate ordering, the failure rate ordering, the dispersive ordering, and the less uncertainty ordering with respect to the location parameter.

AMS 2020 subject classifications: 62G30, 60E15, 60K10
Analysis on the Legal Definition of Jus Cogens Provided in Article 53 of the Vienna Convention on the Law of Treaties
Authors: Pak Hui-Chol , Son Hye-Ryon , Jong Son-Gyong
Published: December 2022

The 1969 Vienna Convention on the Law of Treaties is a fundamental treaty providing rights and obligations that states assume in the conclusion and implementation of treaties. Some of the provisions of the Convention, however, continue to divide the legal scholarship. One of them concerns the legal definition of jus cogens provided in Article 53 of the Vienna Convention on the Law of Treaties. The international community, particularly the International Law Commission, has exerted strenuous efforts for a long time to reach a consensus on jus cogens. Nevertheless, the legal definition of jus cogens is still open to varying interpretation among different countries and international publicists.

In this light, the article analyses the legal definition of jus cogens in three aspects. First, the connotation of the concept ‘peremptory norms of general international law’ is assessed in terms of particular, general and universal international law. Second, it analyses some problems arising in understanding the non-derogability from and modifiability of jus cogens. Finally, the article discusses some issues regarding ‘acceptance and recognition’ of jus cogens by the ‘international community of states as a whole’.
CBD Oil as a Miracle Drug: A Thematic Analysis of Caregivers’ Attitudes and Practices Towards Cannabidiol in Dementia Treatment
Authors: Kłosińska Urszula , Leszko Magdalena
Published: December 2022

The aim of this study was to understand caregivers of individuals with dementia attitudes toward CBD oil. Thematic analysis was conducted with 67 posts (570 comments) about CBD oil selected from a Polish online support forum for caregivers. We identified caregivers’ expectations, motivations, and practices of using CBD oil. Caregivers expected CBD to improve the behavior, cognition, communication, and daily activities of their loved ones. They motivated each other by sharing experiences about the positive effects of CBD oil and claimed to be administering CBD oil without medical advice, which led to dangerous practices such as an overnight withdrawal of all drugs or experimenting with CBD oil dosage. Caregivers perceive CBD oil as a safer and more effective treatment for those with dementia than the conventional methods. We recommend healthcare professionals inquire about possible CBD oil usage during follow-up visits and thoroughly explain what to expect from prescribed medications.
Dying a ‘Good’ Death: The Work, Care, and Support of End-of-Life Doulas
Authors: Dellinger Page Amy , Husain Jonelle H. , Kvanvig Ashley M.
Published: December 2022

End-of-life doulas (EOLDs) are a growing population of care providers who focus on the wishes of the dying person in order to cultivate an environment of comfort, peace, and support from the point of terminal diagnosis, during the dying process, and following death. The purpose of this study was to document the time commitment of EOLDs to dying persons and their loved ones during the dying process, as well as their experiences navigating family dynamics working towards increased acceptance of death. A mixed-methods approach was utilized to gather data on EOLDs, consisting of a quantitative survey with 618 respondents and subsequent qualitative interviews conducted with 39 participants. Results indicated that the amount of time spent with dying persons and their loved ones varies widely and often depends on when the EOLD is contracted regarding services. Factors that impede and lead to great acceptance of death are discussed as well as the role of EOLDs in navigating family dynamics.
Cross-electrospun PVDF/PVDF-HFP nanofibrous membrane with central combination design and its waterproof and moisture permeable composite fabric
Authors: Liu Yanbo , Zhu Xinyu , Chen Yunxia , Zhou Cong , Chen Zhijun , Hao Ming , Hu Xiaodong , Yang Bo
Published: December 2022

Waterproof and moisture permeable composite fabric with electrospun nanofibrous membrane has been widely used, because of its high specific surface area, high porosity, small pore size, uniform pore distribution and light weight. However, there are fewer studies on fabricating waterproof and permeable composite fabric with optimal polyvinylidene fluoride/polyvinylidene fluoride hexafluoropropylene electrospun nanofibrous membrane by multi-needle cross-electrospinning technology and hot-press process. In this study, excellent waterproof and moisture permeable polyvinylidene fluoride/polyvinylidene fluoride hexafluoropropylene electrospun nanofibrous membranes with the optimal process conditions were prepared through central combination design with Design Expert 8.0.5 and experimental validation. The composite fabrics with three different adhesives were prepared. The contact angle, waterproof and moisture permeability, and mechanical properties of composite fabrics were tested. The results showed that CF-1 had better performance with high hydrostatic pressure of 9840 mmH2O, strong moisture permeability of 10,280 g · m−2 · d−1, and excellent peel strength and tensile tenacity. It was of great significance to realize the industrial production of waterproof and breathable composite fabric with electrospun nanofibrous membrane by multi-needle cross-electrospinning technology and hot-press process.
Militarization as Personal Cultivation: Student Military Training in Guomindang China, 1928–1937
Authors: Fong Sau-yi
Published: December 2022

By examining the Guomindang’s (GMD’s) on-the-ground implementation of its student military training program, this article addresses the ideological tensions and diplomatic predicaments underlying the party-state’s youth mobilization strategies. While fetishizing a regimented society, the program incorporated a heterogeneous set of tactics to both inspire and control youth martial activism. The peculiar mix of military discipline, Confucian modes of education, and liberal ideals of voluntarism and competition gave rise to multifarious experiences and sentiments that muddied the main objective of the state—to convert military training into a form of personal cultivation. This study sheds light on the gap between Chiang Kai-shek’s conception of militarization as the practice of everyday discipline and Chinese students’ embrace of military training as patriotic resistance against Japanese invasion. Ultimately, the program’s mobilizational potential was undercut by its obsession with managing the trivialities of everyday life and Nanjing’s appeasement policy toward Japan.
Theoretical and Social Implications of Alternative ‘Feminist’ Media: Sexual Harassment and Intersectional Advocacy in India
Authors: Mukherjee Ishani , Shah Priya V. , Dexter Tina E.
Published: December 2022

What makes alternative digital media ‘alternative’ is critical content and being a ‘prosumer’ platform that champions social justice and change. An Indian digital zine, and our present case study for critical alternative media, is Feminism in India (FII) and its news coverage of the #MeTooIndia movement from 2017 to 2021. In this article, we adopt the critical theory of alternative media and transnational intersectionality frameworks to perform a critical-cultural review of the theoretical, sociopolitical, and change-making implications of FII . We aim to explore its role as alternative media that presents intersectional perspectives and advocacy opportunities in relation to India and its transnational #MeToo mobilizations against sexual harassment. As ‘critical content’ is what defines alternative media, we argue that FII is a critical news site that democratizes gender-diverse narratives and introduces a rupture within India's politically-pandered and patriarchally-primed mainstream media.
On the iron cage: Infrastructural worlding in Mandate Palestine
Authors: Meiton Fredrik
Published: December 2022

Perhaps the most famous image of Palestinian life under the British (1917–1948) is that of the “iron cage.” Rashid Khalidi, the historian who coined the term in the context of Palestine, was referring to a political and military apparatus, operated by the British mandatory government, that constrained the Palestinian leadership to the point of rendering it incapable of taking any effective political action. This article holds on to the notion of the iron cage, but proposes to stretch its meanings in two directions. First, toward the material: the precise properties of the materials and technologies used in building modern Palestine had important consequences for the nature of the territory that emerged, as well as for the Arab–Israeli conflict with which Palestine, as a late-colonial territory, coevolved. The second direction in which the article extends Khalidi’s image is toward its Weberian meaning, as the upshot of the “formal, calculative rationality” of modern capitalism. In doing so, the article argues that the iron cage also operated as a material regime.
Towards more valid scoring criteria for integrated reading-writing and listening-writing summary tasks
Authors: Chan Sathena , May Lyn
Published: December 2022

Despite the increased use of integrated tasks in high-stakes academic writing assessment, research on rating criteria which reflect the unique construct of integrated summary writing skills is comparatively rare. Using a mixed-method approach of expert judgement, text analysis, and statistical analysis, this study examines writing features that discriminate summaries produced by 150 candidates at five levels of proficiency on integrated reading-writing (R-W) and listening-writing (L-W) tasks. The expert judgement revealed a wide range of features which discriminated R-W and L-W responses. When responses at five proficiency levels were coded by these features, significant differences were obtained in seven features, including relevance of ideas, paraphrasing skills, accuracy of source information, academic style, language control, coherence and cohesion, and task fulfilment across proficiency levels on the R-W task. The same features did not yield significant differences in L-W responses across proficiency levels. The findings have important implications for clarifying the construct of integrated summary writing in different modalities, indicating the possibility of expanding integrated rating categories with some potential for translating the identified criteria into automated rating systems. The results on the L-W indicate the need for developing descriptors which can more effectively discriminate L-W responses.
Effects of clozapine treatment on the improvement of substance use disorders other than nicotine in individuals with schizophrenia spectrum disorders: A systematic review and meta-analysis
Authors: Rafizadeh Reza , Danilewitz Marlon , Bousman Chad A , Mathew Nickie , White Randall F , Bahji Anees , Honer William G , Schütz Christian G
Published: December 2022

Background:

Antipsychotic medications are the mainstay of treatment for schizophrenia and are associated with a reduction in psychiatric hospitalization and overall mortality. Some evidence suggest that antipsychotic medications might have a varying effect on the improvement of comorbid substance use disorders (SUDs), with clozapine showing more favorable outcomes.

Aim:

We systematically reviewed all available evidence on effects of clozapine on the improvement of SUDs other than nicotine.

Methods:

Electronic searches of MEDLINE, Embase, PsycINFO, and CINHAL were conducted up to March 1, 2022. Studies of any methodological design involving two concepts: (1) clozapine and (2) SUD terms (excluding nicotine) were included. For SUD outcomes with three or more comparative studies with available raw data meta-analysis was performed. SUD outcomes not meeting criteria for meta-analysis were described qualitatively. Risk of bias was examined using “Downs and Black,” and “Q-Coh” instruments.

Results:

The majority of individuals in the included 31 studies were male and of European ancestry. Abstinence was the most common outcome. Most of the studies were of low-to-moderate quality, and none of the studies met all the quality criteria. Pooled findings from four observational studies in samples of patients with predominantly comorbid alcohol use disorder showed that clozapine treatment is associated with significantly higher odds of remaining abstinent. In addition clozapine was associated with decreased odds of psychiatric hospitalization in all but one observational study.

Conclusions:

Our systematic review and meta-analysis builds upon previous reviews, and it suggests the association of clozapine treatment with significantly higher odds of remaining abstinent from substance use and decreased likelihood of psychiatric hospitalization, compared with continuing treatment with other antipsychotic medications. Still, the validity of this association needs greater exploration and providing recommendations for the utility of clozapine in individuals without treatment-resistant psychosis and comorbid SUDs would be premature.
Suggestions for Future Research in the Area of Workforce Development Systems and Regional Economic Development in the United States
Authors: Hollenbeck Kevin
Published: December 2022

Workforce development systems operate as a linchpin between individuals who desire or need to develop skills that will be remunerated well and will lead to fulfilling careers in the labor market and employers who desire skilled workers who will be productive in the workplace. These systems, however, have been criticized for failings at both ends of the system: they have not served well individuals from underrepresented populations, and they have not been responsive to the changing nature of work and employment relationships. This commentary suggests that these are the most cogent problems to be addressed in future workforce development research. Needed are subgroup analyses of each phase of education and training opportunities: outreach efforts, participation, interest and skill assessments, retention and completion, supportive services, and post-program labor market impacts. Also important will be research into the other side of the market: how can workforce development systems do a better job at inculcating skills that are needed to be productive in the workforce and skills that better meet the future demands of employers?
Characterization of Serous Cell-Free DNA in Myelodysplastic Syndromes
Authors: Zhu Hongbo , Feng Guangjia , Zhao Na , Wu Lei , Long Zhiguo
Published: December 2022

Myelodysplastic syndromes (MDS) are a group of malignant clonal diseases presenting abnormal development of acquired hematopoietic progenitor/stem cell myeloid differentiation. MDS have been clinically divided into different types. There is a lack of clear gold standard, which makes the diagnosis of MDS with clinical signs and laboratory examination difficult. Cell-free DNA (cfDNA) is a resource of DNA fragments from apoptotic or necrotic cells, and has been considered as a measurement with ample sensitive, specific, and effective traits for auxiliary diagnosis. In this study, we collected 25 cases of relatively high-risk MDS (HRM), 22 cases of low-risk MDS (LRM), and 15 cases of benign blood diseases (control) and conducted reduced representation bisulfite sequencing (RRBS) to investigate the variants and DNA methylation of cfDNA in serum of three cases of each group. We observed increased single-nucleotide polymorphisms (SNPs) particularly distributed in intergenic and intronic regions in HRM compared with LRM and control. Moreover, HRM presented more nonsynonymous and harmful variants that would affect amino acid sequence. Meanwhile, we also observed that global DNA methylation on non-CpG sites (CHG and CHH) in HRM was obviously higher than that in LRM and control. Finally, we picked up the candidate genes with specific variants and abnormal methylation at the promoter in HRM and LRM, and combined to examine the specificity and sensitivity of HRM and LRM diagnosis in our collection. We found that FANCM with T49G mutation at first exon and promoter hypermethylation (−835 to transcription start site [TSS]) was indicated as the most confident factor with the highest area under curve (AUC) value (0.9271) for HRM. Similarly, ICAM1 with C1211T mutation at sixth exon and promoter hypermethylation (−282 to TSS) was suggested to identify LRM (AUC = 0.9338). Taken together, our study characterized the variants and methylation pattern of cfDNA in MDS, and provided the potential biomarkers for HRM and LRM identification.
If You Give Bureaucrats an Inch, Will They Take a Yard? Lessons from Threshold Regulatory Reform in Italy
Authors: Finocchiaro Castro Massimo , Guccio Calogero , Romeo Domenica
Published: December 2022

The role of discretion in public procurement has been the subject of wide debate in regulation literature and practice. Greater discretion potentially may allow for greater efficiency in procurement. However, when social capital and institutional quality are low, more discretion can easily open the door to bribery and corruption. In this paper, adopting a semiparametric approach and using a large dataset of public works managed by Italian municipalities, we empirically assess the effects of a reform in the regulation of public works in Italy, approved in 2011, that has increased the discretion of bureaucrats in the choice of the firms. The results provide evidence that the reform has exerted a positive, although mild, effect on the performance of public works execution. However, the positive role of the reform is more relevant in those areas where the effect of public service norms and prosocial behaviors are higher.
Analysis of Sex-Specific Prostanoid Production Using a Mouse Model of Selective Cyclooxygenase-2 Inhibition
Authors: Upmacis Rita K , Becker Wendy L , Rattendi Donna M , Bell Raven S , Jordan Kelsey D , Saniei Shayan , Mejia Elena
Published: December 2022

Background:

Prostanoids are a family of lipid mediators formed from arachidonic acid by cyclooxygenase enzymes and serve as biomarkers of vascular function. Prostanoid production may be different in males and females indicating that different therapeutic approaches may be required during disease.

Objectives:

We examined sex-dependent differences in COX-related metabolites in genetically modified mice that produce a cyclooxygenase-2 (COX2) enzyme containing a tyrosine 385 to phenylalanine (Y385F) mutation. This mutation renders the COX2 enzyme unable to form a key intermediate radical required for complete arachidonic acid metabolism and provides a model of selective COX2 inhibition.

Design and Methods:

Mice heterozygous for the Y385F mutation in COX2 were mated to produce cohorts of wild-type, heterozygous, and COX2 mutant mice. We investigated whether the genotype distribution followed Mendelian genetics and studied whether sex-specific differences could be found in certain prostanoid levels measured in peritoneal macrophages and in urinary samples.

Results:

The inheritance of the COX2 mutation displayed a significant deviation with respect to Mendel’s laws of genetics, with a lower-than-expected progeny of weaned COX2 mutant pups. In macrophages, prostaglandin E2 (PGE2) production following lipopolysaccharide (LPS) and interferon gamma (IFNγ) stimulation was COX2-dependent in both males and females, and data indicated that crosstalk between the nitric oxide (NO) and COX2 pathways may be sex specific. We observed significant differences in urinary PGE2 production by male and female COX2 mutant mice, with the loss of COX2 activity in male mice decreasing their ability to produce urinary PGE2. Finally, female mice across all 3 genotypes produced similar levels of urinary thromboxane (measured as 11-dehydro TxB2) at significantly higher levels than males, indicating a sex-related difference that is likely COX1-derived.

Conclusions:

Our findings clearly demonstrate that sex-related differences in COX-derived metabolites can be observed, and that other pathways (such as the NO pathway) are affected.
The platformization of feminism: The tensions of domesticating Instagram for activist projects
Authors: Barbala Astri Moksnes
Published: December 2022

This article explores how contemporary feminism has become increasingly platformized, focusing on how Scandinavian feminist opinion leaders negotiate Instagram as an integral part of their everyday lives. Drawing on 3 years of digital observations and interviews with activists with over 12,000 followers each, the article investigates the meeting between Instagram’s script and feminist users who might not utilize the technology in line with the platform’s intentions. The analysis takes cues from domestication studies and underlines the morality and materiality involved in the appropriation of technology, pointing at the tensions arising when doing feminism and making culture is intertwined through the everyday use of social media platforms. Building on recent scholarship on the platformization of culture, the article offers novel contributions into how platformization affects non-profit countercultural projects.
Instructing the neoliberal student on the conduct of school: A case study of a schoolwide positive behavior system in kindergarten
Authors: Brown Christopher P , Englehardt Joanna , Ku Da Hei
Published: December 2022

Schoolwide positive behavior interventions and supports continue to be employed in elementary school settings that children attend across the globe. Such neoliberal systems of conduct teach children how to portray themselves as students so that they are ready to succeed in school and the larger society. For the most part, these systems are framed as successful behavior interventions. As a result, how such programs impact school personnel and students’ own conceptions of what it means to be a student is rarely troubled. Thus, through examining a case study of schoolwide positive behavior interventions and supports in a kindergarten classroom in the United States, we investigated this issue. Specifically, we employed Foucault’s conceptions of neoliberalism and biopolitics to examine how a sample of school personnel and kindergarteners made sense of their schoolwide positive behavior system. Doing so provided us with the opportunity to rethink and challenge these neoliberal systems of control.
Autoethnographic engagement in participatory action research: Bearing witness to developmental transformations for college student activists
Authors: Vang MaiNeng , Wolfgram Matthew , Smolarek Bailey , Lee Lena , Moua Payeng , Thao Ariana , Xiong Odyssey , Xiong Pa Kou , Xiong Ying , Yang Lisa
Published: December 2022

This article documents and analyzes autoethnographic engagement in participatory action research (PAR)—a reflective, irritative, and dialogic writing and team-discussion process which documents researcher-activist experiences and contextualizes them within the action research process. We document autoethnography as implemented in a research partnership between HMoob American college student activists and education researchers, to study the systems of oppression and inform advocacy to support HMoob American students at a predominantly white university. Autoethnography informs all aspects of the PAR project, from the development of research questions, to data collection, analysis, and writing, to the implementation of plans for action. We provide evidence from selections of the team’s autoethnographic journals, of the role of autoethnographic engagement as a PAR research technique that can facilitate and bear witness to the developmental transformations for emerging PAR activists—specifically, the cultivation of critical consciousness, the critical re-framing of issues of cultural-community identity, and the formation of an identity as a researcher-activist. We argue that autoethnography provides a practical technique for PAR teams for engaging in iterative cycles of critical self-reflective praxis (Freire, 2011), facilitating the development of critically-engaged researchers and the formation of analyses that are epistemologically grounded and action-oriented, addressing issues of power asymmetries within research.
A retrospective analysis on the product recall due to solvent and mineral residue issues
Authors: Ahmed Salman , Musyuni Pankaj , Aggarwal Geeta
Published: December 2022

Drug recalls are essential to maintaining the safety process because the medical industry’s top objective is primarily to deliver higher-quality goods to a larger population. They do this by eliminating subpar products from the market. Drug recalls are increasing quickly as a result of increased investigation rates, the emergence of industrialization and the online era into the sector, and regulatory authorities and health experts are now focusing on more stringent regulations to prevent further recalls of faulty pharmaceutical drugs. The purpose of the present write-up is to give an overview of how drug recalls work with the help pf examples of recalls due to presence of undesired solvents and mineral residue, how they affect the pharmaceutical business, and what can be done to stop them.
Prelacrimal Approach to Maxillary Sinus Pathology
Authors: Seresirikachorn Kachorn , Kondo Mickey , Png Lu Hui , Kalish Larry , Campbell Raewyn G. , Alvarado Raquel , Harvey Richard J.
Published: December 2022

Background

Access to the anterior, lateral, inferior, and inferomedial maxillary sinus has been a limitation of the middle meatal antrostomy. Expanded techniques such as the modified medial maxillectomy provide access to many of these areas but require remucosalization, and crusting can occur during the recovery phase. The prelacrimal approach (PLA) offers direct 0° endoscope access to these areas. Additionally, PLA can preserve the nasolacrimal duct and mucosal coverage.

Objectives

We describe the current surgical technique and outcomes of PLA patients.

Methods

Consecutive adult patients with pathology addressed by PLA to the maxillary sinus were assessed. The primary outcome was the restoration of the lateral wall, and the secondary outcomes were early (< 90 days) and late morbidity (> 90 days).

Results

Forty patients (52.8 ± 17 years, 62.5% female) were assessed. All patients had successful restoration of the lateral nasal wall (100% [95CI: 91.2%-100%]). The complications reported were primarily dysesthesia (early 10% and late 2.5%).

Conclusion

The PLA provides robust access to the anterior, lateral, inferior, and inferomedial maxilla. PLA offers rapid mucosal recovery while preserving the normal physiology and the lacrimal systems with low morbidity.
Latinization of the Kazakh Alphabet: Implications for Education, Inclusion, and Social Cohesion in Kazakhstan
Authors: Bekzhanova Zhazira , Makoelle Tsediso Michael
Published: December 2022

Kazakhstan’s decision to transition its Kazakh language from the Cyrillic to the Latin alphabet has serious implications for language policy, communication, education, inclusion, and social cohesion. This critical qualitative study, underpinned by a discourse-historical approach, employs critical discourse analysis to analyze statements of ex-President Nursultan Nazarbayev and semi-structured interviews with Kazakh language educators and social media articles to determine the nature and effects of the Latinization of Kazakh on social cohesion, inclusion, and inclusive education. The findings indicate that Latinization of Kazakh is gradually becoming more ethnically oriented, implying that the inevitable formation of included and excluded language groups. These patterns in society might undermine social cohesion and inclusion, hinder their maintenance and hamper efforts to achieve inclusive education, which prioritizes equality for all social groups through proper access to knowledge.
The roles of multinational enterprises in implementing the United Nations Sustainable Development Goals at the local level
Authors: Eang Monida , Clarke Amelia , Ordonez-Ponce Eduardo
Published: December 2022

Multinational enterprises (MNEs) play a fundamental role in advancing the implementation of the United Nations Sustainable Development Goals (SGDs), as they enable cities and communities to reach large-scale solutions. In this article, we analyze 348 MNEs’ sustainability reports with explicit reference to the SDGs to identify the different roles that MNEs play in advancing the SDGs at the local level. Through qualitative content analysis, the literature on MNEs’ roles was validated, extended, and two new roles were found. The five roles of MNEs in local sustainable development that were validated are financer, community capacity builder, product and service provider, partner, and innovator. The three that were extended are employee developer, supply chains and procurement developer, and program deliver, while the two new additions are consultant and awareness raiser. The results of bivariate analyses show that some MNE roles are correlated to headquarter region and the industry sector. The 10 roles are also relevant for implementing all 17 SDGs and 102 of the 169 SDG targets.

JEL CLASSIFICATION: M14