bluuebunny/crossref_metadata_2025 huggingface dataset:
MiR-106b-5p represses neuropathic pain by regulating P2X4 receptor in the spinal cord in mice
Authors: Du Huiying , Tan Xinran , Wei Xuhong , Yuan Zhongmin , Gong Qingjuan
Published: July 2020

Background: P2X4 receptor (P2X4R)-mediated spinal microglial activation makes a critical contribution to pathologically enhanced pain processing in the dorsal horn. It can be upregulated under conditions of neuropathic pain. However, the specific mechanism of pathogenesis and potential molecular targets has not yet been made explicit. MicroRNAs (miRNAs) are commonly recognized as indicators in neuropathic pain pathophysiology.Methods: We established the pain model of spared nerve injury (SNI), and the 50% paw withdrawal thresholds (PWMTs) were used to assess behavior of mouse. MiRNA expression profiling was performed to detect differential expressed miRNA. The western-bolt and quantitative real time PCR to examine P2X4R and miRNA expression in the mouse. Dual-luciferase reporter assays confirmed the correlation between P2X4R and miRNA. Fluorescence in situ hybridization was used to show location between P2X4R and miRNA. Results: In the present study, we found that P2X4R was up-regulated in the spinal dorsal horn of mice following spared nerve injury (SNI), and we identified 69 miRNAs (46 up-regulated and 23 down-regulated miRNAs) were differently expressed (fold change > 2, P < 0.05). P2X4R was a major target of miR-106b-5p (one of down-regulated miRNAs in SNI) with bioinformatics technology and quantitative real time PCR analysis validated the expressed change of miR-106b-5p, and dual-luciferase reporter assays confirmed the correlation between them. Fluorescence in situ hybridization showed that miR-106b-5p was co-localized with P2X4R in the spinal cord. Transfection with miR-106b-5p mimic on BV2 cells reversed the up-regulation of P2X4R induced by LPS. Moreover, miR-106b-5p overexpression significantly attenuated neuropathic pain induced by SNI, with decreased expression of P2X4R mRNA and protein in the spinal cord.Conclusion: Taken together, our results suggest that miR-106b-5p can serve as an important regulator of neuropathic pain development by targeting P2X4R.
Lower Diagnostic Costs Associated With Early Deployment of Capsule Endoscopy in Non-hematemesis Gastrointestinal Bleeding: A Cost-utilization Analysis
Authors: Jawaid Salmaan , Maranda Louise , Cave David
Published: July 2020

Introduction: Often, the diagnostic workup of patients presenting with non-hematemesis gastrointestinal bleeding (NHGIB) is inconclusive. Consequently, the diagnostic evaluation may incur unnecessary health care costs and diagnostic times. The use of a cost decision-analytical model of the current diagnostic management strategy applied to patients presenting with NHGIB may reveal alternative strategies for the evaluation of NHGIB.Methods: Cost decision-analytical model that retrospectively follows the diagnostic course of 231 consecutive patients presenting with NHGIB to the emergency department (ED) of a tertiary medical center. We measured the effect (cost and relative times) of selecting a specific procedure, plus the effect of pursuing secondary procedures after non-diagnostic primary procedures.Results: A primary VCE had a diagnostic rate of 68% vs. 45% and 48% for a primary EGD and COLO, respectively. Combining the diagnostic rates for each primary procedure with the cost of performing subsequent procedures (after non-diagnostic primary procedures), demonstrates the primary use of VCE (n=9) results in a total cost of $12,146 vs. $12,746 and $13,162 for a primary EGD (n=47) and COLO (n=33), respectively. Similarly, the use of VCE as a primary diagnostic procedure in NHGIB patients admitted to the floor would take 74 unit hours to reach a diagnosis compared to 104 and 131 for EGD and COLO, respectively.Conclusion: Our model suggests initial use of VCE for the diagnosis of acute NHGIB, may reduce time to diagnosis and management costs.
Impact of risk of bias on the magnitude of treatment effects of randomized controlled trials in implant dentistry
Authors: Ding Ruolin , Lu Wenxin , Yi Jianru , Zhang Liang , Zhao Zhihe
Published: July 2020

Background: Risk of bias (RoB) could influence the magnitude of treatment effects of randomized controlled trials (RCTs). This study aims to investigate the potential influence of RoB on treatment effects estimates in RCTs in implant dentistry. Methods: The RCTs published in five leading oral implant journals during the recent five years were electronically searched. The RoB was assessed using the Cochrane Collaboration RoB tool. The meta-regression analysis and Monte Carlo permutation test were performed to identify the association between RoB and the magnitude of treatment effects.Results: A considerable amount of studies have high RoB in blinding of participants and personnel, and unclear RoB in allocation concealment and selective reporting. The treatment effects were exaggerated by flaws in allocation concealment for binary outcomes and by deficiencies in random sequence generation and selective reporting for continuous outcomes.Conclusion: RoB frequently exists in RCTs recently published in implant dentistry, which may lead to the exaggeration of treatment effects. Better study design, implementation, and reporting are required for clinical trials in implant dentistry to ensure more reliable evidence.
Validation and Reliability of the Chinese Version of the Miller Behavioral Style Scale
Authors: Zhuo Qiqi , Liang Hongmin , Bai Yangjuan , Hu Qiulan , Hanum Ardani Latifah , Yang Mingfang , Wang Yanjiao , Wei Wei , Ding Lan , Ma Fang
Published: July 2020

Objectives: To test the psychometric properties of the Chinese version of Miller Behavioral Style Scale(C-MBSS).Methods: The forward-back-translation procedure was adopted in the translation of the Miller Behavioral Style Scale. Content validity was assessed in a panel of experts. In a sample of 1343 individuals, reliability and construct validity were assessed using Cronbach’s alpha coefficient and factor analysis. For exploratory factor analysis, parallel analysis was used to decide number of factors, principal axis factoring and direct oblimin rotation method were used to select factor. For confirmatory factor analysis, structural equation modelling was established to verify the extracted factor structure.Results: The C-MBSS achieved conceptual and semantic equivalence with the original scale. The item content validity index(I-CVI) of each item ranged from 0.78 to 1, and the averaging scale content validity index(S-CVI/ Ave) was 0.95. The cronbach`s alpha coefficient for the scale and sub-scales were over 0.6. The exploratory factor analysis resulted in 2-factor assumption for each hypothetical threat-evoking scenario. Confirmatory factor analysis provided confirmatory evidence for the second-order factor structure of 2-factor solution (Monitoring and Blunting) and demonstrated a good fit between theoretical model and data. Conclusions: This study verified the psychometric properties of the C-MBSS and indicated that the C-MBSS can be used to identify individual`s information-seeking style in Chinese population. With the use of the C-MBSS, health care professionals in China can deliver health education based on patients’ information-seeking behavior, which can improve the effect of health education and patients’ health outcomes.
Integrating Transcriptomics for the Identification of Potential Age-related Genes and Cells in Three Major Urogenital Cancers Across the Cancer Genome Atlas
Authors: Cao Jinlong , Li Jianpeng , Yang Xin , Li Pan , Yao Zhiqiang , Han Dali , Ying Lijun , Wang Lijie , Tian Junqiang
Published: July 2020

Background: Cancer is often defined as a disease of aging. The majority of patients with urogenital cancers are the elderly, whose clinical characteristics are greatly affected by age and aging. Here, we aimed to explore age-related biological changes in three major urogenital cancers by integrative bioinformatics analysis.Methods: First, mRNA (count format) and clinical data for bladder cancer, prostate cancer and renal cell carcinoma were downloaded from the Cancer Genome Atlas (TCGA) portal. The expressions of 64 cells were obtained by xCell deconvolution method. EdgeR package and limma package were used to analyze differentially expressed genes and cells in the young group and the old group, respectively. ClusterProfiler R package and clueGO plugin were used for enrichment analysis, and cytohubba plugin was used for hub genes analysis. Then co-expression analysis and chromosome distribution for hub genes were analyzed and demonstrated by RIdeogram R package. The clinical correlation of hub genes and key cells was analyzed by Graphpad Prism software. Finally, the correlation between hub genes and key cells was explored by corrplot R package.Results: We screened and identified 14 hub genes and 4 key cells related to age and urogenital cancers. The age-related differentially expressed genes and co-expressed genes were mainly enriched in muscle movement (Cl-, Ca2+), inflammatory response, antibacterial humoral immune response, substance metabolism and transport, redox reaction, etc. Most of the age-related genes are on chromosome 17. Moreover, the correlation between cells and genes was analyzed. Conclusion: Our study analyzed age-related genes and cells in the tumor microenvironment of urogenital cancers, and explored the pathways involved. This could contribute to personalized therapy for patients of different ages and a new understanding of the potential relationship between the aging microenvironment and urogenital cancers.
Mediating Effect of Deteriorated Kidney Function in Comorbidity-related Excess Deaths in COVID-19: A Retrospective Cohort Study
Authors: Luo Dongling , Liu Qiaomei , Xie Changming , Wang Weidong , Wang Xiong , Wu Juan , Xi Maomao , Yin Yilin , Xiong Di , Wu Yuwei , Xie Yuqing , Shi Ximin , Luo Pengcheng , Dong Fang , Huang Hui
Published: July 2020

Background In-hospital death risks vary in COVID-19 patients with comorbidities. Kidney function decline is prevalent in this course. Methods To explore the exact role of deteriorated kidney function, we applied a retrospective cohort study including 1266 participants in Wuhan Tongren Hospital between January 27 and March 3, 2020. Demographic characteristics, preexisting comorbidities history, organ function data and outcomes were extracted. Deteriorated kidney function was identified as the decline percentage, assessed by an increase in peak serum creatinine from the baseline. Mediating effect was calculated by mediation analysis. Key Results 1266 hospitalized COVID-19 patients (60±15 years, 47.8% are male) were included, with an overall in-hospital death rate of 4.42% (56/1266). For critical cases, 77.02% had at least one preexisting comorbidity. Patients with comorbidities suffered higher in-hospital death and more severe decline of kidney function. Compared to patients with minor function decline (<10%), significant risk increase was found in those with more severe one (OR 3.57; 95%CI 1.70 to 7.52; P=.001 for moderate with 10-50% decline, and 37.45; 95%CI 18.71 to 74.55; P＜.001 for severe with>50%). More interestingly, the mediation analysis found deteriorated kidney function played as an important mediator between different comorbidities and COVID-19 patients’ in-hospital death, with the mediation effect of 11%, 12%, 16% and 32% respectively for hypertension, COPD, CVD and CKD.Conclusions Deteriorated kidney function is strongly associated with increase of in-hospital death in COVID-19 and partially mediates the facilitating effect of preexisting comorbidities on in-hospital death. Thus, dynamic monitoring kidney function, preventing the deterioration of kidney function might be helpful to improve survival in COVID-19 patients, especially those with preexisting comorbidities.
“Patient-Related Risk Factors For Superficial Surgical Site Infection And The Correlation To Periprosthetic Joint Infection – A 5year Follow-up Of 1291 Elective Primary Total Joint Arthroplasties”
Authors: Eriksson Hannah K , Lazarinis Stergios
Published: July 2020

Background: The incidence of superficial surgical site infection (SSSI) may increase the risk of subsequent periprosthetic joint infection (PJI). Optimisation or even avoiding patient-related risk factors for SSSI preoperatively, may decrease the risk of subsequent PJI. Purpose: To identify patient-related risk factors associated with SSSI and investigate their correlation with the progression of PJI. Methods: 1,291 primary elective hip and knee prosthesis were included. Patients were personally contacted by a nurse ≥ 3 month after surgery to answer questions about the postoperative period, including any occurrences of SSSI. The diagnosed PJI was determined by an orthopaedic surgeon together with a specialist in infectious diseases, and all patients with PJI underwent revision surgery. The patient-related risk factors considered relevant were joint, age, sex, American Society of Anesthesiologists classification (ASA), body mass index (BMI), smoking, diabetes and rheumatological disease. Results: 7,0 % of included patients developed an SSSI, and 1,9 % a PJI. Factors with a significantly increased adjusted risk ratio for SSSI were; knee surgery 1,9 (95% CI: 1,2 – 3,1), age ≥ 65 years 1,7 (95% CI: 1,1 – 2,8), BMI ≥35 2,3 (95% CI: 1,2 – 4,2) and for PJI; knee surgery 2,6 (95% CI: 1,1 – 6,4), ASA-class ≥ 3 3,2 (95% CI: 1,3 – 7,9), BMI ≥35 3,0 (95% CI: (1,2 – 4,2) and male gender 3,0 (95% CI: (1,2 – 7,5). Male patients showed a significant risk of developing PJI following SSSI, with a risk ratio of 3,3 (95% CI: 1,1 – 10,5).Conclusions: Male patients planned for total knee prostheses (TKA) aged 65 or over, with high ASA-class and high BMI should be selected with care due to the increased risk of postoperative infection.
Mutually Risk Roles of Oral Cleanliness and Stroke-associated Pneumonia in Patients with Acute Ischemic Stroke: A Cross-Sectional Study
Authors: Yang Xiaohua , Chen Huijuan , Yang Wanling , Deng Bin , Zheng Jialing , Wei Juan , Li Chunguang , Huang Yanjun , Gao Xiaoya , Xie Haiting , Li Minzi , Chen Aimin , Huang Zhilin , Yang Qin , He Juan , Zhang Juan , Hu Tingting , Tao Xi , Wang Qing
Published: July 2020

Background: Stroke-associated pneumonia (SAP) is a major complication after stroke, oral microorganisms are important contributors to SAP. Here, we aimed to investigate whether the oral hygiene was associated with SAP and related risk factors of them in patients with acute ischemic stroke. Methods: We performed a cross-sectional study that recruited 331 patients with acute ischemic stroke from two medical centers. A series of assessments were performed to evaluate the neurological status and habits of oral hygiene. According to whether the oral hygiene was abnormal and SAP occurred, univariate analyses were performed in cohort 1 (normal / abnormal oral hygiene groups) and cohort 2 (SAP / non-SAP groups). Multiple logistic regression analyses were conducted to confirm risk factors of oral cleanliness and SAP in stroke patients. Results: A total of 12 and 8 independent variables were included in the model 1 and 2 analysis. After adjusting for confounders, multivariable logistic regression analysis showed that oral cleanliness was not only closely related to SAP (OR=2.219, P=0.026), dental caries (OR=1.292, P=0.005) and age (OR=1.030, P=0.006) in model 1, but also an independent risk factor for predicting SAP (OR=1.678, P=0.001) in model 2. Barthel index was a protective factor for oral cleanliness (OR=0.986, P=0.019) and SAP (OR=0.977, P=0.002) in ischemic stroke patients. Conclusions: Mutually primary risk roles of abnormal oral cleanliness and SAP exist in patients with acute ischemic stroke. Dental caries and aging are important risk factors for oral health disorders. Improving the activities of daily living would have protective effects on both oral hygiene and SAP prevention in stroke patients.
Impact of the Covid-19 lockdown period on adult musculoskeletal injuries and surgical management: a retrospective monocentric study
Authors: Crenn Vincent , Kinani Monia El , Pietu Guy , Marie Leteve , Persigant Mike , Toanen Cécile , Varenne Yoann , Goffinet Nicolas , Buffenoir Kevin , Javaudin François , Montassier Emmanuel
Published: July 2020

Background

The coronavirus disease 2019 (COVID-19) pandemic has led to the worldwide implementation of unprecedented public protection measures. On the 17th of March, the French government announced a lockdown of the population for 8 weeks. This monocentric study assessed the impact of this lockdown on the musculoskeletal injuries treated at the emergency department as well as the surgical indications.
Methods

We carried out a retrospective study in the Emergency Department and the Surgery Department of Nantes University Hospital from 18 February to 11 May 2020. We collected data pertaining to the demographics, the mechanism, the type, the severity, and inter-hospital transfer for musculoskeletal injuries from our institution. We compared the four-week pre-lockdown period and the eight-week lockdown period divided into two four-week periods: early lockdown and late lockdown.
Results

There was a 52.1% decrease in musculoskeletal injuries among patients presenting to the Emergency Department between the pre-lockdown and the lockdown period (weekly incidence: 415.3 ± 44.2 vs. 198.5 ± 46.0, respectively, p < .001). The number of patients with surgical indications decreased by 33.4% (weekly incidence: 44.3 ± 3.8 vs. 28.5 ± 10.2, p = .048). The policy for inter-hospital transfers to private entities resulted in 64 transfers (29.4%) during the lockdown period. There was an increase in the incidence of surgical high severity trauma (Injury Severity Score > 16) between the pre-lockdown and the early lockdown period (2 (1.1%) vs. 7 (7.2%), respectively, p = .010) as well as between the pre-lockdown and the late lockdown period (2 (1.1%) vs. 10 (8.3%), respectively, p = .004). We observed a significant increase in the weekly emergency department patient admissions between the early and the late lockdown period (161.5 ± 22.9, 235.5 ± 27.7, respectively, p = .028).
Conclusion

A pronounced decrease in the incidence of musculoskeletal injuries was observed secondary to the lockdown measures, with emergency department patient admissions being halved and surgical indications being reduced by a third. The increase in musculoskeletal injuries during the late confinement period and the higher incidence of severe trauma highlights the importance of maintaining a functional trauma center organization with an inter-hospital transfer policy in case of a COVID-19 second wave lockdown.
A Case Report on the Surgical Management of Subhepatic Perforated Appendicitis: A Rare Presentation
Authors: Hakim Mumin , Mostafa Rania , Shehri Mohammed Al , Sharawy Sherif
Published: July 2020

Background: Subhepatic appendicitis is an exceedingly rare presentation accounting for 0.01% of Acute appendicitis. It is of prime importance to be aware of various variants and thereby managing such challenging cases accordingly.Case presentation: We present a middle-aged female patient with subhepatic perforated appendicitis and peritonitis who underwent an exploratory laparotomy and appendectomy.Conclusions: Surgical management of such patients is challenging due to an atypical presentation. The surgical management of such patients is discussed with a brief review of literature.
Laboratory Markers and Characteristics of New HIV Infections Among Adolescents in Zambia
Authors: Moyo Tina Nanyangwe , Moyo Nkuye , Zheng Xiaoying , Kalibala Samuel , Qiao Xiaochun , Guo Chao , Sweeny Kim , Wu Jilei
Published: July 2020

Background

We aimed to explore HIV RNA (ribonucleic acid) virologic levels greater than 1,000 copies/millilitre (ml), among HIV-positive adolescents aged 15–24 years, establish the spread of CD4 T- cell counts and inspect characteristics of adolescents presenting with new HIV infections, including co-infections with Hepatitis B virus and syphilis.
Methods

We analysed data from the Zambia Population-based HIV Impact Assessment 2016 survey. Two-stage stratified cluster probability sample design was used to select the target population. Our study truncated the population to focus on the age-group 15–24 whose biomarker tests and household information were complete. Our primary outcome measure was “New HIV-positive Infections among 15-24-year-olds” defined as HIV-positive biomarker samples presenting with HIV RNA ≥ 1,000 copies/ml without detectable ARVs. We tested associations between new HIV infections and clinical characteristics using negative binomial models adjusting for age, sex, education, marital-status, residence among several covariates.
Results

Overall, 2·3% ([166/7320], 95% CI: 1·9–2·6) adolescents aged 15–24 years were diagnosed with new HIV infections, with greater proportions among females (3·3% [139/4,165], 95% CI: 2·8–3·9) than males (0·86% [27/3,155], 95% CI: 0·6–1·2). Almost half (47·6%) of seroconversions had HIV RNA ≥ 50,000 copies/ml and an average CD4 + T-cell count of 479 cells/mm 3. HBV– positive adolescents (IRR 8·6, 95% CI: 2·9–24·9, P < 0·001, model 2) were at increased risk of new infections unlike those testing positive for syphilis antibodies (IRR 1·22, 95% CI: 0·2–8·3, P < 0·84). Adjusting for confounders revealed that being married or cohabiting, testing positive for HBV, being a rural resident and attaining higher than secondary education emerged as strongest correlates of new infections.
Conclusion

High baseline levels of viral load and low CD4 + T-cell count in recent HIV infections among adolescents indicate weak immune repertoire at first diagnosis, increasing the risk of contagion. As the epidemic continues to spread within the adolescent population, HIV-infection will become more complex and greater proportions of adolescents will likely be infected by regular partners. This suggests growing need for interventions targeted at stable partnerships and intensified public health campaigns specific for adolescents.
IMPROVEMENT OF ORGANOLEPTIC INDICATORS OF CHEESE PRODUCTS BY CORRECTING FATTY ACID COMPOSITION OF FAT PHASE
Authors: Lepilkina О. V. , Mordvinova V. A. , Topnikova E. V. , Ostroukhova I. L. , Danilova E. S.
Published: July 2020

The aim of the study was to establish the possibility of improving the organoleptic characteristics of cheese products by introducing butyric acid into the composition of the used vegetable fat composition. Cheese products made using two fat compositions consisting of refined, deodorized vegetable fats, including those modified by interesterification, were studied. The experimental fat composition contained in its composition additional butyric acid added to the composition of triglycerides. The study of cheese products was carried out in the process of ripening and storage for 120 days in comparison with cheese, the fat phase of which is represented by milk fat. It was found that the degree of proteolysis, estimated by the ratio of total water-soluble nitrogen to total nitrogen, does not depend on the nature of the fat in the protein matrix. Milk fat in cheeses is more subjected to lipolysis than vegetable fats in cheese products. The addition of butyric acid to the vegetable composition in an amount of 0.8% increased the acidity of the fat phase by 0.1 mmol/100 g. According to the assessment of organoleptic characteristics, cheese with milk fat had the most pronounced cheese flavor and aroma, cheese product without butyric acid in fat phase had the least pronounced ones. A cheese product with a fat composition containing added butyric acid was close to cheese with milk fat in terms of the severity of cheese taste, rheological characteristics and the spectrum of volatile flavoring substances. It is concluded that the taste and aroma of cheese products have a positive effect on adjusting the fatty acid composition of vegetable fat compositions by introducing butyric acid into their composition.
Penelusuran Ragam Jenis Bambu di Kota Langsa, Aceh
Authors: Ritonga Muhammad Azli , Nurchalidah Siti , Karmiati Karmiati , Navia Zidni Ilman , Suwardi Adi Bejo
Published: July 2020

Langsa City has a wealth of plant species that need to be studied, especially bamboo plants. This study aims to explore the types of bamboo found in Langsa City. The study was conducted from April to July 2019 using the exploration method. The method of sample collection by purposive sampling. The results showed that in Langsa City there were found 4 genera bamboo namely Bambusa, Gigantochloa, Schizostachyum, and Thyrsostachys which consisted of 6 species of bamboo namely Bambusa multiplex (Lour.) Raeusch. Ex Schhult., Bambusa vulgaris Schrad. Ex Wendl., Gigantochloa apus (J.A. & J.H.Schult.) Kurz, Gigantochloa atter (Hassk.) Kurz, Schizostachyum brachycladum (Kurz) Kurz, and Thyrsostachys siamensis Gamble. The most widespread bamboo distribution in Langsa was found in Langsa Lama and Langsa Baro amounted to 5 species.
Kinetic analysis of sucrose activated carbon for nutrient removal in water
Authors: Jamaliniya Sara , Basu O. D. , Suresh Saumya , Musvoto Eustina , Mackintosh Alexis
Published: July 2020

A renewable, green activated carbon made from sucrose (sugar) was compared with traditional bituminous coal-based granular activated carbon (GAC). Single and multi-component competitive adsorption of nitrate and phosphate from water was investigated. Langmuir and Freundlich isotherm models were fitted to data obtained from the nitrate and phosphate adsorption experiments. Nitrate adsorption fits closely to either Freundlich or Langmuir model for sucrose activated carbon (SAC) and GAC with a Langmuir adsorption capacity of 7.98 and 6.38 mg/g, respectively. However, phosphate adsorption on SAC and GAC demonstrated a selective fit with the Langmuir model with an adsorption capacity of 1.71 and 2.07 mg/g, respectively. Kinetic analysis demonstrated that adsorption of nitrate and phosphate follow pseudo-second-order kinetics with rate constant values of 0.061 and 0.063 g/(mg h), respectively. Competitive studies between nitrate and phosphate were demonstrated in preferential nitrate removal with GAC and preferential phosphate removal with SAC. Furthermore, nitrate and phosphate removals decreased from 75% removal to 35% removal when subject to multi-component solutions, which highlights the need for adsorption analysis in complex systems. Overall, SAC proved to be competitive with GAC in the removal of inorganic contaminants and may represent a green alternative to coal-based activated carbon.
Chalcone Derived Pyrazole Synthesis via One-pot and Two-pot Strategies
Authors: Farooq Saba , Ngaini Zainab
Published: July 2020

Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal
fields. Pyrazole is stable compound that is particularly used in pharmaceutical applications
(i.e., anticancer, antifungal, antiviral, antimicrobial and antioxidant) and electronic industries.
This review depicted the synthesis of pyrazoles derivatives by employing chalcone
derivatives as a starting material via one and two-pot strategies. The one-pot strategy is an
exclusive method for chalcone cyclization and oxidation, while two-pot strategy is reported
through the preparation of chalcone derivatives, i.e., pyrazoline, hydrazone and bromochalcone
prior to the synthesis of pyrazole. One-pot strategy is frequently reported for pyrazole
synthesis purposes due to unique, stable, reactive and well-known chalcone reactants
having easy handing then two-pot strategy. This review is momentous in organic chemistry,
especially synthesis related to pyrazole and drug industry.
Withdrawal Notice: Organocatalyzed Asymmetric Mannich Reaction: An Update
Authors: Baagheri Ilnaz , Mohammadi Leila , Zadsirjan Vahideh , Heravi Majid M.
Published: July 2020

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Recent Progress in Iron-Catalyzed Reactions Towards the Synthesis of Bioactive Five- and Six-Membered Heterocycles
Authors: Adak Laksmikanta , Ghosh Tubai
Published: July 2020

Heterocyclic compounds are the largely diverse organic molecules and find
prevalent applications in the fine chemical industry, medicinal chemistry and agricultural
science. They are also among the most commonly bearing frameworks in numerous drugs
and pharmaceutical substances. Therefore, the development of convenient, efficient and
environmentally benign methods to produce various types of heterocyclic compounds is
an attractive area of research. For the synthesis and functionalization of heterocycles,
enormous achievements have been attributed over the past decades. Recently, ironcatalyzed
reactions have accomplished a noteworthy development in the synthesis of
heterocycles. This review highlights some remarkable achievements in the iron-catalyzed
synthesis of heterocyclic compounds published in the last five years.
The Tumor Suppressor Role of the Ras Association Domain Family 10
Authors: Hou Yulong , Li Shuofeng , Du Wei , Li Hailong , Wen Rumin
Published: July 2020

The Ras association domain family 10(RASSF10), a tumor suppressor gene, is located on human chromosome 11p15.2, which is one of the members homologous to other N-terminal RASSF families obtained through structural prediction. RASSF10 plays an important role in inhibiting proliferation, invasion, and migration, inducing apoptosis, making cancer cells sensitive to docetaxel, and capturing G2/M phase. Some studies have found that RASSF10 may inhibit the occurrence and development of tumors by regulating Wnt/β-catenin, P53, and MMP2. Methylation of tumor suppressor gene promoter is a key factor in the development and progression of many tumors. Various methylation detection methods confirmed that the methylation and downregulation of RASSF10 often occur in various tumors, such as gastric cancer, lung cancer, colon cancer, breast cancer, and leukemia. The status of RASSF10 methylation is positively correlated with tumor size, tumor type, and TNM stage. RASSF10 methylation can be used as a prognostic factor for overall survival and disease-free survival, and is also a sign of tumor diagnosis and sensitivity to docetaxel chemotherapy. In this review, we mainly elucidate the acknowledged structure and progress in the verified functions of RASSF10 and the probably relevant signaling pathways.
Модификация и полировка штриха голографической дифракционной решетки пучком нейтрализованных ионов Ar
Authors: Гарахин С.А. , Зорина М.В. , Зуев С.Ю. , Михаленко М.С. , Пестов А.Е. , Плешков Р.А. , Полковников В.Н. , Салащенко Н.Н. , Чхало Н.И.
Published: July 2020

Описан метод увеличения эффективности голографических дифракционных решеток (ГДР), предназначенных для рентгеновского диапазона длин волн. Описана процедура обработки поверхности ГДР пучком ускоренных ионов с целью понижения амплитуды и шероховатости штрихов. Для понижения амплитуды штриха применялись ионы Xe с энергией 600 eV, для ионной полировки --- ионы Ar с энергией 800 eV. Показано увеличение дифракционной эффективности решетки на длине волны 4.47 nm почти в 4 раза после ионной полировки. Ключевые слова: дифракционная решетка, монохроматор Черни-Тернера, ЭУФ диапазон длин волн, ионная полировка поверхности, атомно-силовая микроскопия.
Многослойные зеркала Cr/Sc с улучшенным отражением для диапазона "окна прозрачности воды"
Authors: Полковников В.Н. , Гарахин С.А. , Квашенников Д.C. , Малышев И.В. , Салащенко Н.Н. , Свечников М.В. , Смертин Р.М. , Чхало Н.И.
Published: July 2020

Изучены свойства многослойных зеркал Cr/Sc, синтезированных при пониженном значении электрической мощности на магнетронном разряде. Найдены модельные структурные параметры таких зеркал. Получен рекордный коэффициент отражения 21% на длине волны 3.12 nm. Ключевые слова: микроскопия, "водное окно", многослойные зеркала, рентгеновское излучение, магнетронное напыление.
Влияние коллективных эффектов на концентрационную зависимость предела текучести сплавов при высокоэнергетических воздействиях
Authors: Малашенко В.В.
Published: July 2020

The high-strain rate deformation of aged alloys is theoretically analyzed. In the framework of a unified approach, various types of concentration dependence of the yield strength observed in the experiment are explained.

Malashenko V.V., Donetsk Institute for Physics and Engineering named after A.A.Galkin, Donetsk National University
DURATION OF TREATMENT HOURS AND LEVEL OF DEPENDENCE OF CANCER PATIENTS AFFECT CAREGIVER’S STRESS LEVEL
Authors: Werdani Yesiana Dwi Wahyu
Published: July 2020

Introduction: Cancer is a disease with complex side effects that can interfere with the body functions, impacting on increasing patient dependence on caregivers. Objectives: This study objectives was to prove the duration of treatment hours and the level of dependence of cancer patients affect caregiver’s stress level. Methods: This was a cross-sectional study. Population 50 caregivers who live at the Indonesian Cancer Foundation East Java Branch Surabaya Indonesia and only 30 samples were chosen based on inclusion criteria. Instruments used duration of treatment hours questionnaire, KATZ index and caregiver stress self-assessment. All instruments had been tested validity and reliability. Ethical procedures were done before the research starts. After the data collected it was analyzed used a multinomial logistic regression test with p < 0.05. Result: The majority of participants taking care of cancer patients for 4 – 6 hours/day (56.7%), most of the cancer patients who treated by caregivers, experienced moderate levels of dependence (50%) and the majority of caregivers experienced stress at moderate levels (56.7%). There was a significant effect between the duration of treatment hours and the level of dependence of cancer patients on the caregiver’s stress level. The duration of treatment hours affect 34.3% on caregiver’s stress level (p = 0.03) and level of patient’s dependence affect 41.9% (p = 0.01). Conclusion: The longer hours of care lead to less caregiver’s free time for their personal needs, so that most of the time is used for patient care. Likewise, the higher the level of patient dependence on caregivers, the more time is given for care and can further trigger stress on caregivers.
Digital or Digitally Delivered Responses to Domestic and Intimate Partner Violence During COVID-19
Authors: Emezue Chuka
Published: July 2020

Before the coronavirus disease (COVID-19), 1 in 3 women and girls, globally, were victimized by an abusive partner in intimate relationships. However, the current pandemic has amplified cases of domestic violence (DV) against women and girls, with up to thrice the prevalence in DV cases compared to the same time last year. Evidence of the adverse effects of the pandemic on DV is still emerging, even as violence prevention strategies are iteratively being refined by service providers, advocacy agencies, and survivors to meet stay-at-home mandates. Emotional and material support for survivors is a critical resource increasingly delivered using digital and technology-based modalities, which offer several advantages and challenges. This paper rapidly describes current DV mitigation approaches using digital solutions, signaling emerging best practices to support survivors, their children, and abusers during stay-at-home advisories. Some examples of technology-based strategies and solutions are presented. An immediate priority is mapping out current digital solutions in response to COVID-19–related DV and outlining issues with uptake, coverage, and meaningful use of digital solutions.
Ozone therapy for patients with SARS-COV-2 pneumonia: a single-center prospective cohort study (Preprint)
Authors: Hernandez Alberto , Viñals Montserrat , Pablos Asunción , Vilas Francisco , Papadakos Peter J , Wijeysundera Duminda , Vives Marc
Published: July 2020

BACKGROUND

Aside from supportive management, there remains no specific treatment for Coronavirus Disease 2019 (COVID-19).

OBJECTIVE

Determine whether the use of ozonated autohemotherapy is associated with shorter time to clinical improvement in patients with severe COVID-19 pneumonia.

METHODS

Design: Single-center proof-of-concept prospective cohort study.
Setting: Internal Medicine ward at Policlinica Ibiza Hospital, Spain.
Participants: Eighteen consecutive patients with laboratory confirmed COVID-19 infection and severe pneumonia who were admitted to hospital between 20th March and 19th April 2020.
Patients in the ozonated autohemotherapy arm received hemotherapy twice daily starting on the day of admission for a median of 4 days. Each treatment involved administration of 200 mL autologous whole blood enriched with 200 mL of oxygen-ozone mixture with a 40 μg/mL ozone concentration. Patients in the control arm received supportive care. Assignment to hemotherapy versus usual care was determined based on the admitting physician on the day of admission, with only one of the three possible physicians prescribing ozonated autohemotherapy.
Main Outcomes: The primary outcome was time from hospital admission to clinical improvement, which was defined as either hospital discharge or a two-point improvement in clinical status measured on a six-point ordinal scale. Secondary outcomes were clinical improvement measured on the 7th, 14th and 28th day after admission, as well as time to a 2-fold reduction in concentrations of C-protein reactive, ferritin, D-dimer and lactate dehydrogenase.

RESULTS

The mean age of the cohort was 68 y and 72% (n=13) were male. Nine patients (50%) received ozonated autohemotherapy beginning on the day of admission. In unadjusted comparisons, ozonated autohemotherapy was associated with significantly shorter time to clinical improvement (median [IQR]), 7 days [6-10] vs 28 days [8-31], p=0.04) and significantly higher proportion of patients achieving 14-day clinical improvement (88.8% vs 33.3%, p=0.01). In risk-adjusted analyses, ozonated autohemotherapy was associated with a shorter mean time to clinical improvement (-11.3 days, p=0.04, 95% CI -22.25 to -0.42).

CONCLUSIONS

Ozonated autohemotherapy was associated with a significantly shorter time to clinical improvement in this prospective cohort study. Given the small sample size and single-center study design, these observations require evaluation in larger randomized controlled trials.

CLINICALTRIAL

NCT04444531
Determinant of Preemptive Corporate Restructuring
Authors: Lim Joohyun
Published: July 2020

In this paper, I investigate whether companies with high quality accounting information carry out preemptive corporate restructuring or not. I find the higher the quality of accounting information, the more proactive the corporate restructuring for the following reasons. First, Board of Directors overseeing the management basically identifies the financial position and performance of the entity through accounting information, it will encourage the management to make preemptive restructuring decisions when it is necessary to improve its operating performance or improve its financial structure through corporate restructuring such as the sale of assets, interests, affiliates and business units. Second, high-quality accounting information will play a role in enhancing possibility of completion of corporate restructuring. This finding suggests that high quality of accounting information was required as a determinant that could enhance the practicability of preemptive restructuring.
KOMPETENSI MAHASISWA PADA PEMBELAJARAN MATEMATIKA MENGGUNAKAN GEOMETER’S SKETCHPAD DENGAN AUTHENTIC ASSESSMENT
Authors: Syaifuddin Mohammad , Susanti Reni Dwi , Azmi Rizal Dian
Published: July 2020

Penelitian ini bertujuan untuk melihat bagaiamana penggunaan Geometer’s Sketchpad pada pemahaman konsep Matematika dengan authentic asessment dan bagaiama hasilnya. Penelitian ini menggunakan The One-Shot Case Study dan menggunakan tes, observasi dan pemberian angket sebagai teknik pengumpulan data. Penggunaan Geometer’s Sketchpad pada pemahaman konsep matematika dengan menggunakan Authentic Asessment dapat dikatakan sangat membantu dalam proses perkuliahan dan konsep tentang vektor lebih mudah dipahami. Hasil dari penggunaan Geometer’s Sketchpad pada pemahaman konsep matematika dikatakan sangat baik dan terdapat perbedaan yang sangat signifikan dibandingkan dengan kelas yang tanpa digunakan media Geometer’s Sketchpad dalam kegiatan pembelajaran.
A Design of Experiment Approach for Optimization and Characterization of Clarithromycin Ternary System Using Spray Drying
Authors: Shete Nikhil Arun , Swami Vishwajeet M. , Chaudhari Avinash , Khabiya Prachi N.
Published: July 2020

The aim of present work was to characterize Clarithromycin (CLT), Polyvinyl pyrrolidone K30 (PVP K30) and Hydroxypropyl β-cyclodextrin (HPB) ternary system so as to check the effect of complexation on solubility of CLT. Physical mixtures of a drug and polymers in several weight ratios (1:1, 1:2) were prepared to check the effect of individual polymers on solubility of CLT. Spray drying method was accustomed investigate the combined effect of PVP K30 and HPB on Drug release (DR), Dissolution efficiency (DE) and mean dissolution time (MDT) of CLT. For the preparation and optimization of ternary system the Design of experiment (DoE) was used . Drug polymer interactions were analyzed with Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray diffraction (XRD) and particle size analysis. Results of solubility study suggested that there was significant increase in solubility of CLT with increase within the concentration of PVP K30 and HPB (*p<0.05). This may be thanks to the solubilizing effect of PVP K30 and sophisticated formation of CLT with HPB. Various combinations of PVP K30 and HPB prepared using DoE approach by spray drying method showed greater solubility of CLT than its physical mixtures (*p<0.05). Results of FTIR, DSC, XRD and particle size analysis revealed the interaction between CLT, PVP K30 and HPB. This suggested formation of amorphous ternary system with mean particle diameter within the range of 312±1.35 nm. Combine use of PVP K30 and HPB with DoE approach was an efficient tool for formulating ternary system of CLT.

Keywords: Clarithromycin, Spray drying, polyvinyl pyrrolidone K30, Hydroxypropyl β-cyclodextrin, Design of experiments, Ternary system.
ANALISIS DAN PERANCANGAN SISTEM INFORMASI PENGARSIPAN SURAT BERBASIS WEB PADA KANTOR LURAH DESA DAYAH TUHA
Authors: Rozana Liza , Musfikar Rahmat
Published: July 2020

An archive is an important document that is saved with a purpose when it is needed again it is easy to find it. The archive plays an important role in Dayah Tuha Village's Lurah office, so it is highly hoped that the process of managing the archives is good, fast, and easy. If the files that are owned are not well managed it will impact the difficulty of finding the information and it can impede the next stage of work. Therefore, the archive must be managed with a good and correct management system. In this research, discusses the analysis and design of a web-based document, which is suitable for the needs of the office of Tuha Village. The design of this information system based on the design of systems that have been compiled include use case diagram, activity and sequence Diaram. Dayah Tuha Village's office is still using the manual way of managing the archives. So that by the existence of this system is expected to help the work in the head office of Dayah Tuha in terms of the management of archives.
IMPLEMENTASI ALGORITMA NAIVE BAYES DAN RANDOM FOREST DALAM MEMPREDIKSI PRESTASI AKADEMIK MAHASISWA UNIVERSITAS ISLAM NEGERI AR-RANIRY BANDA ACEH
Authors: Yusuf Bustami , Qalbi Muthmainna , Basrul Basrul , Dwitawati Ima , Malahayati Malahayati , Ellyadi Mega
Published: July 2020

Academic achievement is determined by two factors, namely internal factors originating from within the individual in this case students and external factors that come from outside the individual or things that are influenced by the environment. There are many ways to find an academic achievement, one of which uses data mining which aims to predict or classify data using a classification algorithm. This study aims to 1) find out how to apply the Naive Bayes algorithm to student achievement, and 2) see the accuracy of the Naive Bayes algorithm to student achievement. This type of research is secondary data in the form of student data obtained from the information technology center and the Ar-Raniry UIN database. This research uses Naive Bayes algorithm and random forest algorithm. The results obtained from this study indicate the highest correlation value in the initial IP variable of r = 0.783 and the leave variable has a very weak correlation level of r = 0.054. The accuracy value of Naive Bayes algorithm after cleaning is 78.0% and Random Forest algorithm variable is 76.7%.
HAKIKAT ADMINISTRASI PEMERINTAHAN ISLAM
Authors: Anzaikhan M.
Published: July 2020

As a teaching that originates from revelation, Islam does not only speak in the orientation of aqidah and worship alone. More than that, Islam also discusses all scientific dimensions including good and efficient administrative models. The process of Islamization can take the form of a classical concept that is being tried again, or an offer for the future as a media solution in responding to the current government administration. A nation as large as the era of the Prophet Muhammad would not have survived if there were no solid and ideal government administration system. Likewise, in the time of the Bani Ummayah, the Abbasids, even the Ottoman era which carved the history of Islam as the largest and most respected group of its time. Once again, this glory could not have been achieved if the Islamic government at that time did not have the knowledge of qualified government administration. Administration is divided into two. (1) Administration in the strict sense is an administrative activity which includes the activities of note-taking, correspondence, bookkeeping and filing of letters as well as other matters intended to provide information and facilitate obtaining information back if needed. (2) Administration in the broad sense is the translation of the narrow meaning that includes the external function of the correspondence itself. Whether it is the background of the letter, the purpose of the letter, the benefits of the letter, the deadline of the letter, and so forth. On the scientific plane, administration has close significance with other scholars such as history, politics, social science, psychology, and even other applied sciences.
EFFECT OF COUNSELOR COMPETENCE ON STUDENT INTEREST IN GROUP GUIDANCE SERVICES
Authors: BULANTIKA SITI ZAHRA
Published: July 2020

Personality counselor competence in the implementation of guidance and counseling, one of them in group guidance services are needed to be a competent counselor. It will continue to increase, in line with the development of counseling, especially to foster enthusiasm and be one of the reasons that students have an interest in participating in group counseling services. Attention plays a significant role in the lives of students and has a tremendous impact on attitudes and behavior. Through the provision of group guidance services, students are directed to participate in group discussion activities and function to prioritize the development of communication and socialization skills.