bluuebunny/crossref_metadata_2025 huggingface dataset:
Fibrosis score predicts mortality in patients with fibrotic hypersensitivity pneumonitis
Authors: Oh Ju Hyun , Kang Jieun , Song Jin Woo
Published: March 2023

Background

Variable clinical courses make it challenging to predict mortality resulting from fibrotic hypersensitivity pneumonitis (HP). This study evaluated the usefulness of radiologic parameters for predicting mortality in patients with fibrotic HP.

Methods

Clinical data and high-resolution computed tomography (HRCT) images, which were scored for reticulation, honeycombing, ground glass opacity (GGO), consolidation, and mosaic attenuation (MA) by visual assessment, were retrospectively analyzed in a total of 101 patients with fibrotic HP (all biopsy-proven cases). Fibrosis score was defined as the sum of reticulation and honeycombing scores.

Results

The mean age of the 101 patients was 58.9 years, and 60.4% were females. During the follow-up (median: 55.5 months; interquartile range: 37.7–89.0 months), the 1-, 3-and 5-year mortality rates were 3.9, 16.8, and 32.7%, respectively. The non-survivors were older and had significantly lower lung function and minimum oxygen saturation during the 6-min walk test than the survivors. The non-survivors had higher scores of reticulation, honeycombing, GGO, fibrosis, and MA on HRCT than survivors. In the multivariable Cox analysis, reticulation, GGO, and fibrosis scores were independent prognostic factors for mortality in patients with fibrotic HP, as well as age. Fibrosis score showed great performance for predicting the 5-year mortality (AUC = 0.752, p < 0.001) and higher mortality was recorded for patients with high fibrosis score (≥12.0%) (the mean survival time: 58.3 vs. 146.7 months, p < 0.01) than those without.

Conclusion

Our results suggest that radiologic fibrosis score may be a useful predictor of mortality in patients with fibrotic HP.
Genetically predicted green tea intake and the risk of arterial embolism and thrombosis
Authors: Jia Lingmei , Chen Yali , Liu Chang , Luan Yinyin , Jia Min
Published: March 2023

Background

In previous observational studies, green tea intake has been demonstrated to protect against arterial embolism and thrombosis. However, whether there is a causative connection between green tea intake and arterial embolism and thrombosis is currently unclear.

Methods

A two-sample Mendelian randomization (MR) study has been designed to explore whether there is a causal association between green tea intake and arterial embolism and thrombosis by acquiring exposure and outcome data from previously published research. Data from the MRC-IEU (data on green tea intake, 64,949 participants) consortium and the FinnGen project (data on arterial embolism and thrombosis, 278 cases of arterial thrombosis and 92,349 control participants) has been utilized to determine the causal impact of green tea intake on arterial embolism and thrombosis.

Results

We found that genetically predicted green tea intake was causally associated with a lower risk of arterial embolism and thrombosis (IVW odds ratio [OR] per SD decrease in green tea intake = 0.92 [95% confidence interval, 0.85–0.99]; p = 0.032). Moreover, the sensitivity analysis (both MR Egger regression and weighted median) yielded comparable estimates but with low precision. No directional pleiotropic effect between green tea intake and arterial embolism and thrombosis was observed in both funnel plots and MR-Egger intercepts.

Conclusions

Our study provided causal evidence that genetically predicted green tea intake may be a protective factor against arterial embolism and thrombosis.
The phylogeny and metabolic potentials of an n-alkane-degrading Venatorbacter bacterium isolated from deep-sea sediment of the Mariana Trench
Authors: Wang Jiahua , Zhang Yan , Liu Ying , Xie Zhe , Cao Junwei , Zhang Hongcai , Liu Jie , Bao Tianqiang , Sun Congwen , Liu Bilin , Wei Yuli , Fang Jiasong
Published: March 2023

Recently, several reports showed that n-alkanes were abundant in the hadal zone, suggesting that n-alkanes could be an important source of nutrients for microorganisms in hadal ecosystems. To date, most of the published studies on the microbial capacity to degrade hydrocarbons were conducted only at atmospheric temperature and pressure (0.1 MPa), and little is known about whether and which microbes could utilize n-alkanes at in situ environmental conditions in the hadal zone, including low temperature and high hydrostatic pressure (especially >30 MPa). In this study, a piezotolerant bacterium, strain C2-1, was isolated from a Mariana Trench sediment at depth of 5,800 m. Strain C2-1 was able to grow at in situ temperature (4°C) and pressure (58 MPa) with n-alkanes as the sole carbon source. Phylogenetically, strain C2-1 and related strains (TMPB967, ST750PaO-4, IMCC1826, and TTBP476) should be classified into the genus Venatorbacter. Metagenomic analysis using ~5,000 publicly available datasets showed that Venatorbacter has a wide environmental distribution in seawater (38), marine sediments (3), hydrothermal vent plumes (2), Antarctic ice (1), groundwater (13), and marine sponge ecosystems (1). Most Venatorbacter species are non-obligate n-alkane degraders that could utilize, at a minimal, C16−C18n-alkanes, as well as other different types of carbon substrates, including carbohydrates, amino acids, peptides, and phospholipids. The type II secretion system, extracellular proteases, phospholipase, and endonuclease of Venatorbacter species were robustly expressed in the metatranscriptomes of deep-sea hydrothermal vents, suggesting their important contribution to secondary productivity by degrading extracellular macromolecules. The identification of denitrifying genes suggested a genus-specific ecological potential that allowed Venatorbacter species to be active in anoxic environments, e.g., the oxygen-minimal zone (OMZ) and the deeply buried marine sediments. Our results show that Venatorbacter species are responsible for the degradation of hydrocarbon and extracellular macromolecules, suggesting that they may play an important role in the biogeochemistry process in the Trench ecosystems.
Alterations in theta-gamma coupling and sharp wave-ripple, signs of prodromal hippocampal network impairment in the TgF344-AD rat model
Authors: van den Berg Monica , Toen Daniëlle , Verhoye Marleen , Keliris Georgios A.
Published: March 2023

Alzheimer’s disease (AD) is a severe neurodegenerative disorder caused by the accumulation of toxic proteins, amyloid-beta (Aβ) and tau, which eventually leads to dementia. Disease-modifying therapies are still lacking, due to incomplete insights into the neuropathological mechanisms of AD. Synaptic dysfunction is known to occur before cognitive symptoms become apparent and recent studies have demonstrated that imbalanced synaptic signaling drives the progression of AD, suggesting that early synaptic dysfunction could be an interesting therapeutic target. Synaptic dysfunction results in altered oscillatory activity, which can be detected with electroencephalography and electrophysiological recordings. However, the majority of these studies have been performed at advanced stages of AD, when extensive damage and cognitive symptoms are already present. The current study aimed to investigate if the hippocampal oscillatory activity is altered at pre-plaque stages of AD. The rats received stereotactic surgery to implant a laminar electrode in the CA1 layer of the right hippocampus. Electrophysiological recordings during two consecutive days in an open field were performed in 4–5-month-old TgF344-AD rats when increased concentrations of soluble Aβ species were observed in the brain, in the absence of Aβ-plaques. We observed a decreased power of high theta oscillations in TgF344-AD rats compared to wild-type littermates. Sharp wave-ripple (SWR) analysis revealed an increased SWR power and a decreased duration of SWR during quiet wake in TgF344-AD rats. The alterations in properties of SWR and the increased power of fast oscillations are suggestive of neuronal hyperexcitability, as has been demonstrated to occur during presymptomatic stages of AD. In addition, decreased strength of theta-gamma coupling, an important neuronal correlate of memory encoding, was observed in the TgF344-AD rats. Theta-gamma phase amplitude coupling has been associated with memory encoding and the execution of cognitive functions. Studies have demonstrated that mild cognitive impairment patients display decreased coupling strength, similar to what is described here. The current study demonstrates altered hippocampal network activity occurring at pre-plaque stages of AD and provides insights into prodromal network dysfunction in AD. The alterations observed could aid in the detection of AD during presymptomatic stages.
Numerical study of magneto-optical binding between two dipolar particles under illumination by two counter-propagating waves
Authors: Abraham-Ekeroth Ricardo Martín
Published: March 2023

Introduction: The formation of a stable magneto plasmonic dimer with THz resonances is theoretically studied for the principal directions of the system. Unlike a recent report, our work provides a complete description of the full photonic coupling for arbitrary magnetic fields as, for instance, unbalanced particle spins.

Methods: As an illustration, we consider two small, n-doped InSb nanoparticles under illumination by two counter-propagating plane waves.

Results: Remarkably, when an external magnetic field exists, the symmetry in the system is broken, and a resonant radiation pressure for the dimer appears. Similarly, tunable inter-particle forces and spins are exerted on the non-reciprocal dimer. The system is also characterized when the magnetic field is absent. Moreover, we show how the mechanical observables truly characterize the dimer since their resonance dependency contains detailed information about the system.

Discussion: Unlike far-field observables like absorption, mechanical magnitudes depend on the system's near-field. In addition, the nature of the particle spins is originally explained by the energy flow's behavior around the dimer. This work constitutes a generalization of any previous approach to optical binding between small nanoparticles. It paves the way for fully controlling optical matter and nano factory designs based on surface plasmon polaritons.
Design of a medical decision-supporting system for the identification of brain tumors using entropy-based thresholding and non-local texture features
Authors: Reddy K. Rasool , Batchu Raj Kumar , Polinati Srinivasu , Bavirisetti Durga Prasad
Published: March 2023

Introduction

Brain tumors arise due to abnormal growth of cells at any brain location with uneven boundaries and shapes. Usually, they proliferate rapidly, and their size increases by approximately 1.4% a day, resulting in invisible illness and psychological and behavioral changes in the human body. It is one of the leading causes of the increase in the mortality rate of adults worldwide. Therefore, early prediction of brain tumors is crucial in saving a patient’s life. In addition, selecting a suitable imaging sequence also plays a significant role in treating brain tumors. Among available techniques, the magnetic resonance (MR) imaging modality is widely used due to its noninvasive nature and ability to represent the inherent details of brain tissue. Several computer-assisted diagnosis (CAD) approaches have recently been developed based on these observations. However, there is scope for improvement due to tumor characteristics and image noise variations. Hence, it is essential to establish a new paradigm.

Methods

This paper attempts to develop a new medical decision-support system for detecting and differentiating brain tumors from MR images. In the implemented approach, initially, we improve the contrast and brightness using the tuned single-scale retinex (TSSR) approach. Then, we extract the infected tumor region(s) using maximum entropy-based thresholding and morphological operations. Furthermore, we obtain the relevant texture features based on the non-local binary pattern (NLBP) feature descriptor. Finally, the extracted features are subjected to a support vector machine (SVM), K-nearest neighbors (KNN), random forest (RF), and GentleBoost (GB).

Results

The presented CAD model achieved 99.75% classification accuracy with 5-fold cross-validation and a 91.88% dice similarity score, which is higher than the existing models.

Discussions

By analyzing the experimental outcomes, we conclude that our method can be used as a supportive clinical tool for physicians during the diagnosis of brain tumors.
Diabetic rats with high levels of endogenous dopamine do not show retinal vascular pathology
Authors: Allen Rachael S. , Khayat Cara T. , Feola Andrew J. , Win Alice S. , Grubman Allison R. , Chesler Kyle C. , He Li , Dixon Jendayi A. , Kern Timothy S. , Iuvone P. Michael , Thule Peter M. , Pardue Machelle T.
Published: March 2023

Purpose

Limited research exists on the time course of long-term retinal and cerebral deficits in diabetic rodents. Previously, we examined short term (4–8 weeks) deficits in the Goto-Kakizaki (GK) rat model of Type II diabetes. Here, we investigated the long-term (1–8 months) temporal appearance of functional deficits (retinal, cognitive, and motor), retinal vascular pathology, and retinal dopamine levels in the GK rat.

Methods

In GK rats and Wistar controls, retinal neuronal function (electroretinogram), cognitive function (Y-maze), and motor function (rotarod) were measured at 1, 2, 4, 6, and 8 months of age. In addition, we evaluated retinal vascular function (functional hyperemia) and glucose and insulin tolerance. Retinas from rats euthanized at ≥8 months were assessed for vascular pathology. Dopamine and DOPAC levels were measured via HPLC in retinas from rats euthanized at 1, 2, 8, and 12 months.

Results

Goto-Kakizaki rats exhibited significant glucose intolerance beginning at 4 weeks and worsening over time (p < 0.001). GK rats also showed significant delays in flicker and oscillatory potential implicit times (p < 0.05 to p < 0.001) beginning at 1 month. Cognitive deficits were observed beginning at 6 months (p < 0.05), but no motor deficits. GK rats showed no deficits in functional hyperemia and no increase in acellular retinal capillaries. Dopamine levels were twice as high in GK vs. Wistar retinas at 1, 2, 8, and 12 months (p < 0.001).

Conclusion

As shown previously, retinal deficits were detectable prior to cognitive deficits in GK rats. While retinal neuronal function was compromised, retinal vascular pathology was not observed, even at 12+ months. High endogenous levels of dopamine in the GK rat may be acting as an anti-angiogenic and providing protection against vascular pathology.
A novel physiological feature selection method for emotional stress assessment based on emotional state transition
Authors: Li Zhen , Xing Yun , Pi Yao , Jiang Mingzhe , Zhang Lejun
Published: March 2023

The connection between emotional states and physical health has attracted widespread attention. The emotional stress assessment can help healthcare professionals figure out the patient's engagement toward the diagnostic plan and optimize the rehabilitation program as feedback. It is of great significance to study the changes of physiological features in the process of emotional change and find out subset of one or several physiological features that can best represent the changes of psychological state in a statistical sense. Previous studies had used the differences in physiological features between discrete emotional states to select feature subsets. However, the emotional state of the human body is continuously changing. The conventional feature selection methods ignored the dynamic process of an individual's emotional stress in real life. Therefore, a dedicated experimental was conducted while three peripheral physiological signals, i.e., ElectroCardioGram (ECG), Galvanic Skin Resistance (GSR), and Blood Volume Pulse (BVP), were continuously acquired. This paper reported a novel feature selection method based on emotional state transition, the experimental results show that the number of physiological features selected by the proposed method in this paper is 13, including 5 features of ECG, 4 features of PPG and 4 features of GSR, respectively, which are superior to PCA method and conventional feature selection method based on discrete emotional states in terms of dimension reduction. The classification results show that the accuracy of the proposed method in emotion recognition based on ECG and PPG is higher than the other two methods. These results suggest that the proposed method can serve as a viable alternative to conventional feature selection methods, and emotional state transition deserves more attention to promote the development of stress assessment.
Pickering emulsions stabilized by β-CD microcrystals: Construction and interfacial assembly mechanism
Authors: Kou Xingran , Zhang Xinping , Ke Qinfei , Meng Qingran
Published: March 2023

β-Cyclodextrin (β-CD) can combine with oil and other guest molecules to form amphiphilic inclusion complexes (ICs), which can be adsorbed on the oil–water interface to reduce the interfacial tension and stabilize Pickering emulsions. However, the subtle change of β-CD in the process of emulsion preparation is easily ignored. In this study, β-CD and ginger oil (GO) were used to prepare the Pickering emulsion by high-speed shearing homogenization without an exogenous emulsifier. The stability of the emulsion was characterized by microscopic observation, staining analysis, and creaming index (CI). Results showed that the flocculation of the obtained Pickering emulsion was serious, and the surface of the droplets was rough with lamellar particles. In order to elucidate the formation process of the layered particles, the GO/β-CD ICs were further prepared by ball milling method, and the X-ray diffraction (XRD), scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and interfacial tension analyses found that β-CD and GO first formed amphiphilic nanoscale small particles (ICs) through the host–guest interaction, and the formed small particles were further self-assembled into lamellar micron-scale amphiphilic ICs microcrystals. These amphiphilic ICs and microcrystals aggregated at the oil–water interface and finally formed the Pickering emulsion. In this study, by exploring the formation process and evolution of GO/β-CD self-assembly, the formation process and stabilization mechanism of the β-CD-stabilized GO Pickering emulsion were clarified preliminarily, with the aim of providing a theoretical basis for the development of high-performance CD-stabilized Pickering emulsions.
Deep learning for real-time detection of breast cancer presenting pathological nipple discharge by ductoscopy
Authors: Xu Feng , Zhu Chuang , Wang Zhihao , Zhang Lei , Gao Haifeng , Ma Zhenhai , Gao Yue , Guo Yang , Li Xuewen , Luo Yunzhao , Li Mengxin , Shen Guangqian , Liu He , Li Yanshuang , Zhang Chao , Cui Jianxiu , Li Jie , Jiang Hongchuan , Liu Jun
Published: March 2023

Objective

As a common breast cancer-related complaint, pathological nipple discharge (PND) detected by ductoscopy is often missed diagnosed. Deep learning techniques have enabled great advances in clinical imaging but are rarely applied in breast cancer with PND. This study aimed to design and validate an Intelligent Ductoscopy for Breast Cancer Diagnostic System (IDBCS) for breast cancer diagnosis by analyzing real-time imaging data acquired by ductoscopy.

Materials and methods

The present multicenter, case-control trial was carried out in 6 hospitals in China. Images for consecutive patients, aged ≥18 years, with no previous ductoscopy, were obtained from the involved hospitals. All individuals with PND confirmed from breast lesions by ductoscopy were eligible. Images from Beijing Chao-Yang Hospital were randomly assigned (8:2) to the training (IDBCS development) and internal validation (performance evaluation of the IDBCS) datasets. Diagnostic performance was further assessed with internal and prospective validation datasets from Beijing Chao-Yang Hospital; further external validation was carried out with datasets from 5 primary care hospitals. Diagnostic accuracies, sensitivities, specificities, and positive and negative predictive values for IDBCS and endoscopists (expert, competent, or trainee) in the detection of malignant lesions were obtained by the Clopper-Pearson method.

Results

Totally 11305 ductoscopy images in 1072 patients were utilized for developing and testing the IDBCS. Area under the curves (AUCs) in breast cancer detection were 0·975 (95%CI 0·899-0·998) and 0·954 (95%CI 0·925-0·975) in the internal validation and prospective datasets, respectively, and ranged between 0·922 (95%CI 0·866-0·960) and 0·965 (95%CI 0·892-0·994) in the 5 external validation datasets. The IDBCS had superior diagnostic accuracy compared with expert (0.912 [95%CI 0.839-0.959] vs 0.726 [0.672-0.775]; p<0.001), competent (0.699 [95%CI 0.645-0.750], p<0.001), and trainee (0.703 [95%CI 0.648-0.753], p<0.001) endoscopists.

Conclusions

IDBCS outperforms clinical oncologists, achieving high accuracy in diagnosing breast cancer with PND. The novel system could help endoscopists improve their diagnostic efficacy in breast cancer diagnosis.
Clinical efficacy of laparoscopic radical hepatectomy and laparotomy for hepatocellular carcinoma and factors of postoperative recurrence
Authors: Cao Qing , Yang Liang , Zhou Guanbao , Hu Yue
Published: March 2023

Objective

For exploring the clinical efficacy of laparoscopic radical hepatectomy and laparotomy for hepatocellular carcinoma and analysing related factors of postoperative recurrence.

Methods

Totally 212 patients with hepatocellular carcinoma admitted to our hospital between April 2017 and December 2020 were enrolled, and all of them were followed up after the operation. According to the treatment modes, the patients were assigned to a laparotomy group (n=106) and a laparoscopic group (n=106). Perioperative indicators, haematological examination results, complications and recurrence were compared between the two groups. The recurrence time of hepatocellular carcinoma after the operation was confirmed by imaging examination with definite mass, and logistic multivariate analysis was used for analyzing the risk factors associated with postoperative recurrence

Results

Patients in both groups were comparable in terms of general baseline data. The laparoscopic group experienced longer operation time and shorter incision length, less intraoperative blood loss, early time to have the first off-bed activity and time to eat liquid and shorter hospital stay than the laparotomy group (all P<0.05). Seven days after the operation, the laparoscopic group showed notably lower levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), tumour necrosis factor-α (TNF-α), interleukin-8 (IL-8), and C-reactive protein (CRP) than the laparotomy group (all P<0.05), and also showed notably higher levels of immunoglobulin A (IgA), IgG and IgM than the laparotomy group (all P<0.05). Additionally, the laparotomy group showed a higher total incidence rate of complications than the laparoscopic group (19.81% vs. 9.43%, P<0.05). During the one-year follow-up, the laparotomy group was not greatly different from the laparoscopic group in recurrence rate (22.64% (24/106) vs. 16.98% (18/106), P>0.05). Multivariate analysis showed that average tumour diameter and microvascular invasion were risk factors for postoperative recurrence (P<0.05).

Conclusion

Laparoscopic radical hepatectomy for hepatocellular carcinoma can reduce the influence on liver function and immune function, with less damage to tissues, and can ameliorate postoperative inflammatory reaction, and promote postoperative recovery of patients as soon as possible. There are many factors influencing the postoperative recurrence of hepatocellular carcinoma, and average tumour diameter and microvascular invasion are the risk factors.
Predicting pathological complete response after neoadjuvant chemotherapy: A nomogram combining clinical features and ultrasound semantics in patients with invasive breast cancer
Authors: Wang Ke-Nie , Meng Ya-Jiao , Yu Yue , Cai Wen-Run , Wang Xin , Cao Xu-Chen , Ge Jie
Published: March 2023

Background

Early identification of response to neoadjuvant chemotherapy (NAC) is instrumental in predicting patients prognosis. However, since a fixed criterion with high accuracy cannot be generalized to molecular subtypes, our study first aimed to redefine grades of clinical response to NAC in invasive breast cancer patients (IBC). And then developed a prognostic model based on clinical features and ultrasound semantics.

Methods

A total of 480 IBC patients were enrolled who underwent anthracycline and taxane-based NAC between 2018 and 2020. The decrease rate of the largest diameter was calculated by ultrasound after NAC and their cut-off points were determined among subtypes. Thereafter, a nomogram was constructed based on clinicopathological and ultrasound-related data, and validated using the calibration curve, receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and clinical impact curve (CIC).

Results

The optimal cut-off points for predicting pCR were 53.23%, 51.56%, 41.89%, and 53.52% in luminal B-like (HER2 negative), luminal B-like (HER2 positive), HER2 positive, and triple-negative, respectively. In addition, time interval, tumor size, molecular subtypes, largest diameter decrease rate, and change of blood perfusion were significantly associated with pCR (all p < 0.05). The prediction model based on the above variables has great predictive power and clinical value.

Conclusion

Taken together, our data demonstrated that calculated cut-off points of tumor reduction rates could be reliable in predicting pathological response to NAC and developed nomogram predicting prognosis would help tailor systematic regimens with high precision.
Serotonin is a gap junction-permeable neuronal tracer in the mouse retina
Authors: Szarka Gergely , Hoffmann Gyula , Kovács-Öller Tamás , Völgyi Béla
Published: March 2023

Introduction

Gap junctions are dynamically modulated bridges allowing the transcellular passage of ions and small molecules with a molecular mass of up to 1 kDa, a mechanism utilized for molecular communication purposes by living cells. This same mechanism is also exploited by scientists to reveal the existence of gap junction contacts by the cell-to-cell movement of tracers. However, multiple labeling experiments require the availability of multiple gap junction-permeable tracers.

Methods

To this end, we utilized the well-known transient OFF alpha retinal ganglion cell (RGC)-coupled array as a model system to study and compare the transjunctional movement of neurobiotin (NB), a commonly used tracer, and serotonin, a recently identified tracer.

Results

Although the transjunctional movement of serotonin has been established in cell cultures, here we show, for the first time, that serotonin is also a potent tracer in in vitro tissue. In addition, serotonin is lighter than the classical gap junction-permeable NB, and thus, we expected that tracer movement would be comparable to or better than that of serotonin. We found that intracellular serotonin injections result in the labeling of the coupled transient OFF alpha RGC array very similar to those of the classical NB-labeled arrays. Both serotonin and NB-injected transient OFF alpha RGCs displayed the well-known pattern with coupled RGCs and a cohort of coupled wide-field amacrine cells (ACs).

Discussion

By using morphological characteristics, we confirm that the serotonin and the NB-coupled AC arrays are identical, and thereby confirm that serotonin is a potent gap junction-permeable tracer and can be readily used as an alternative to NB in in vitro tissue. Moreover, serotonin can be utilized in parallel with other dyes or tracers, enabling the use of multiple labels in the same material.
Skin-to-skin contact—An effective intervention on pain and stress reduction in preterm infants
Authors: Pavlyshyn Halyna , Sarapuk Iryna
Published: March 2023

Introduction

The outcomes of pain and stress in preterm infants in the neonatal intensive care units (NICUs) compel the continued search for pain- and stress-reducing interventions.

The objective of the study

To investigate how skin-to-skin contact (SSC) influences chronic pain and stress in preterm infants in the NICU.

Materials and methods

The study included 140 preterm infants in the NICU with gestational age less than 34 weeks. The overall design was a baseline-response design. Urine and saliva were collected before (baseline) and after SSC to measure pain and stress markers by enzyme immunoassay method. The behavioral indicators of chronic pain were assessed using the EDIN (Échelle Douleur Inconfort Nouveau-Né—neonatal pain and discomfort).

Results

There was a significant decrease in the dopamine level in preterm infants after SSC in comparison with baseline values (85.99 [69.35; 112.20] pg/ml vs. 132.20 [104.80; 183.70] pg/ml), p < 0.001. The β-endorphin and serotonin levels increased after SSC (40.09 [26.81; 70.63] pg/ml vs. 29.87 [20.61; 46.94] pg/ml, p = 0.009 and 25.49 [20.45; 40.08] ng/ml vs. 22.30 [15.13; 31.65] ng/ml, p = 0.011, respectively). A significant decrease in cortisol levels in saliva and urine after SSC in comparison with baseline values (0.125 [0.079; 0.225] μg/dl vs. 0.371 [0.188; 1.002] μg/dl, p = 0.000 and 27.06 [14.59; 35.35] ng/ml vs. 35.25 [19.78; 61.94] ng/ml, p = 0.001, with a simultaneous increase of oxytocin level (57.00 [36.55; 88.49] pg/ml vs. 38.20 [28.78; 56.04] pg/ml, p = 0.009 were revealed. The total pain EDIN score in infants after SSC was below 6 points, significantly decreasing compared to the baseline (p < 0.05).

Conclusion

Preterm infants in the NICU experience stress and pain, which were confirmed by the EDIN pain scale and laboratory markers. The level of dopamine and cortisol as pain and stress hormones were reliably high, and normalized after regular SSC. Simultaneously, pain-relieving and anti-stress markers of oxytocin, β-endorphin and serotonin reliably increased in preterm infants in response to the SSC.
Using the national electronic prescription system to determine the primary non-adherence to medication in the Czech Republic
Authors: Bruthans Jan , Berger Jiří , Šoltés Ján , Michálek Pavel
Published: March 2023

The primary medication non-adherence occurs when a patient does not collect his or her newly prescribed medication. Various studies give estimates that this occurs between 0.2 percent and 74 percent. Recently, this topic has been researched by analyzing data in national electronic prescription systems. The database of the Czech electronic prescription system was used to obtain the number of all prescriptions issued and collected in 2021 for fifty particular substances (associated with six medication groups). Additionally, a similar query was performed with an additional criterion that the same substance had not been prescribed within the last 365 days. The data were obtained separately in five age categories. The total number of prescriptions analyzed in this study was over 21 million, which represents almost 30 percent of all prescriptions issued in the Czech Republic in 2021. The primary medication non-adherence in the selected substances was 4.56 percent, which negatively correlates (rxy = 0.707) with the age of a patient. There is a higher primary non-adherence in the Psychoanaleptics and Lipid modifying medication groups than in the whole studied sample (p < 0.05). Lipid-modifying medication group and several other particular substances showed a larger difference between primary non-adherence and overall non-adherence, indicating issues in the initiation of these drugs. The results of our study are following earlier studies with similar methodologies from other countries. However, the difference between primary non-adherence and overall non-adherence had not been observed in other studies before. The electronic prescription system proved to be a valuable tool for conducting this type of research.
Global trends in the health economics field of PD-1/PD-L1 inhibitors: A bibliometric and visualized study
Authors: Lai Sicen , Xu Licong , Zhang Liang , Peng Lanyuan , Li Yixin , Liu Yuancheng , Yu Nianzhou , Chen Wangqing , Huang Kai
Published: March 2023

Inhibitors of programmed cell death protein 1 and its associated ligand (PD-L1) are widely used in cancer treatment. However, medical costs and benefits of PD-1/PD-L1 inhibitors need attention owing to differences in response rates among individuals. This study explored global trends in the health economics field of PD-1/PD-L1 inhibitors to enhance their worldwide development. Bibliometric analysis of all documents currently indexed in Web of Science Core Collection from inception to 2022 was performed. Publication year, authors, countries, institutes, and journals were analyzed by Bibliometrix package (version 3.2.1) in R (version 4.1.3). CiteSpace (version 6.1.R6) and VOSviewer (version 1.6.18) were used to analyze burst words, co-authorship of institutes, co-cited journals, and co-cited references, while figures were mainly drawn by Ggplot2 package (version 3.3.5) in R (version 4.1.3) and SCImago Graphica Beta (version 1.0.23). A total of 2020 documents related to the health economics of PD-1/PD-L1 inhibitors were identified, and 1,204 documents met the selection criteria for inclusion in the study. A rapid increase in the number of publications since 2019 was observed, but this increase stopped in 2022, revealing research saturation in the field. Value in Health (166 publications, 13.79% of total documents) had the most publications, while New England Journal of Medicine (2,890 co-citations) was the most co-cited journal. The United States was the leading contributor in this field with 506 publications and the top two productive institutes globally. The main hot topics included the cost-effectiveness of treatment with PD-1 and/or PD-L1 inhibitors, and the comparison between the cost-effectiveness of PD-/PD-L1 inhibitors and other drugs. There were substantial differences between developed and developing countries in the health economics field of PD-1 and/or PD-L1 inhibitors. The cost-effectiveness analysis of combined treatment with PD-1/PD-L1 inhibitors and other drugs warrants further attention. Findings from this study may provide governments and pharmaceutical companies with a strong reference for future research.
Thulium-doped fiber laser with switchable single-wavelength output using polarization-dependent loss
Authors: Guan Biao , Yan Fengping , Qin Qi , Liu Yan , Yang Dandan , Tan Haoyu , Li Ting , Yu Chenhao , Wang Xiangdong , Jiang Youchao , Kumamoto Kazuo , Suo Yuping
Published: March 2023

A thulium-doped fiber laser (TDFL) with switchable single-wavelength output was proposed and experimentally constructed, and its output characteristics were investigated. The central wavelengths were 1940.52 nm and 2048.04 nm, defined by a superimposed uniform fiber Bragg grating (SI-UFBG) with reflectivity larger than 92%. Switchable output was successfully achieved by using polarization-dependent loss, with the help of a drop-in polarization controller and an in-line polarizer. For both output wavelengths, optical signal-to-noise ratios larger than 80 dB were achieved. Maximum fluctuations of the central wavelengths of 1940.52 nm and 2048.02 nm under 60 min were, respectively, 0.04 nm and 0.01 nm. Maximum fluctuations of output power for the same wavelengths over the same time period were, respectively, 1.09 dB and 0.12 dB. Maximum output powers of 215.12 mW and 155.53 mW were achieved for the respective output wavelengths of 1940.52 nm and 2048.02 nm. Moreover, a tuning range of ∼2 nm was realized by enforcing a strain on the SI-UFBG. The proposed TDFL may be applied in laser medicine and free-space-related applications.
“How sweet are your strawberries?”: Predicting sugariness using non-destructive and affordable hardware
Authors: Wen Junhan , Abeel Thomas , de Weerdt Mathijs
Published: March 2023

Global soft fruit supply chains rely on trustworthy descriptions of product quality. However, crucial criteria such as sweetness and firmness cannot be accurately established without destroying the fruit. Since traditional alternatives are subjective assessments by human experts, it is desirable to obtain quality estimations in a consistent and non-destructive manner. The majority of research on fruit quality measurements analyzed fruits in the lab with uniform data collection. However, it is laborious and expensive to scale up to the level of the whole yield. The “harvest-first, analysis-second” method also comes too late to decide to adjust harvesting schedules. In this research, we validated our hypothesis of using in-field data acquirable via commodity hardware to obtain acceptable accuracies. The primary instance that the research concerns is the sugariness of strawberries, described by the juice’s total soluble solid (TSS) content (unit: °Brix or Brix). We benchmarked the accuracy of strawberry Brix prediction using convolutional neural networks (CNN), variational autoencoders (VAE), principal component analysis (PCA), kernelized ridge regression (KRR), support vector regression (SVR), and multilayer perceptron (MLP), based on fusions of image data, environmental records, and plant load information, etc. Our results suggest that: (i) models trained by environment and plant load data can perform reliable prediction of aggregated Brix values, with the lowest RMSE at 0.59; (ii) using image data can further supplement the Brix predictions of individual fruits from (i), from 1.27 to as low up to 1.10, but they by themselves are not sufficiently reliable.
Factors affecting domestic tourists’ repeat purchase intention towards accommodation in Malaysia
Authors: SPR Charles Ramendran , Yong Hui Nee Au , Kalhoro Maryam , Dahari Kamarulzaman Bin Mohd , Shaikh Farhan Bashir
Published: March 2023

The hospitality and tourist industries depend on homestays and accommodations. Different factors, i.e., promotion strategies, service quality, cleanliness, and perceived health risks, influence tourists’ repeat purchase intention for accommodation. This study highlights different variables influencing domestic tourists’ accommodation repurchase decisions in Malaysia. Around 304 respondents from this quantitative survey are tourists who have already experienced choosing their accommodations during travel. Statistical Packages of Social science software (SPSS-23.0) were used to examine the data through multiple regression and descriptive approaches. The finding suggests that promotion, and services, can positively affect visitors’ purchasing decisions. However, there is a negative but statistically significant link between perceived health risk and repurchase decisions. Furthermore, the result revealed that the predictors of purchase decisions significantly influence selection. This study observed the undervalued quality of services and facilities provided by the hotel industry. The results identified that sustainable practices could enhance the impressive recovery of the tourism industry during and after the pandemic. Furthermore, cleanliness and cost are vital to be considered a primary quality service factor, reducing the perceived health risk, even if there is a pandemic. The study suggested that lodging providers could upgrade on-site facilities and acquire better promotion strategies. The study’s conclusions can increase satisfaction to avoid health risks in any circumstance and promote tourism.
Comparability and reliability of the positive and negative affect scales in the European Social Survey
Authors: Sortheix Florencia M. , Weber Wiebke
Published: March 2023

This study examined the measurement invariance of the positive and negative affect scales in the European Social Survey (ESS) in 2006 and 2012. We employed Multi-Group Confirmatory Factor Analysis with an estimator for ordinal data, allowing us to test threshold invariance, which had not been previously investigated for these scales. A 3-item measure of Positive Affect and a 5-item measure of Negative Affect showed that configural, threshold and metric (loading) and partial scalar (intercept) invariance held across almost all countries and between the two ESS Rounds. Our results provide cross-cultural validity to a broader measure of negative affect than past research using the ESS and examine these scales across more countries than any past study. Besides providing valuable insights for researchers interested in well-being and the ESS, our study also contributes to the ongoing discussion about diverging analytical choices in invariance testing.
Academic women’s negotiation of gender identities in non-elite Chinese universities
Authors: Yuan Boya , Tian Xiaoming
Published: March 2023

Introduction

This study employs Butler’s concept of identity to unpack how non-elite Chinese university academic women negotiate gender identities under the influence of the wider social discourses around gender in their institutional context.

Methods

The study includes two empirical investigations of (i) semi-structured interviews and (ii) photovoice interviews with six women academics from six different non-elite Chinese universities.

Results and Discussion

We found that most interviewees tended to value their teacher identity and meanwhile downplay their researcher identity in the professional field; while in the private field, they paid more attention to their mother identity at the cost of downplaying their career development. The study also reveals that, in the process of gender negotiation, the interviewees commonly adopted two strategies: (i) creating space and time for identity performance, and (ii) persuading with selves to accept multiple identities. This article contributes to the understanding of Chinese academic women in non-elite public universities from a Butlerian perspective.
Self-referential and social saliency information influences memory following attention orienting
Authors: Zhao Shuo , Uono Shota , Hu Rong Qing , Yoshimura Sayaka , Toichi Motomi
Published: March 2023

Self-referential information is a processing priority in individuals. Whether or how self-referential information plays a role in attention orienting by modulating memory encoding during attention orienting is presently unknown. First, we investigated this role with self-referential processing for words. Participants were trained to associate two cues (red and green arrows) with social labels (the words “self” and “other” in Experiment 1). Then, participants performed a cueing task to determine whether various targets were presented at a right or left location. Finally, a recognition task of target items was implemented to examine the influence of arrow cues on memory. Second, given that the difference in social salience also exists between self-and other-referential processing, we investigate whether the same effect as the self-referential processing of words exists for emotional faces with high social salience and regardless of emotional valence (a high and a low social salience in Experiment 2A; and a positive and a negative emotional face in Experiment 2B). The results showed that self-referential and emotional cues, irrespective of their emotional valence, enhance memory for the indicated target objects across experiments. This suggests that automatic prioritization of social salience for self-referential words or emotional faces plays an important role in subsequent cognitive processing through attention orienting to influence memory.
Relationships between selected indices of postural stability and sports performance in elite badminton players: Pilot study
Authors: Jaworski Janusz , Lech Grzegorz , Żak Michał , Witkowski Kazimierz , Piepiora Paweł
Published: March 2023

The main aim of this study was to determine the relationships between postural stability and the place in the ranking of badminton players. The study examined 10 elite players from Polish national badminton team. The scope of the study included basic somatic characteristics, such as body height, body weight, BMI, and training experience. A Microgate GYKO inertial sensor system was used to assess the postural stability of athletes. Using Spearman’s rank correlation, cause-and-effect relationships between the place in the sports ranking and the analyzed variables characterizing postural stability were recognized. Depending on the distribution and homogeneity of variance, the significance of differences in variables that characterize postural stability between players of different sports skill levels (two groups) was calculated. The Student’st-test or Mann–Whitney’s U-test was used for this purpose. In general, the athletes with higher positions on the ranking list presented a higher level of postural stability in both tests, which is also confirmed by the normalized values. However, for all variables of postural stability, no statistically significant correlations with sports ranking were observed. Higher values of Spearman’s rank correlation coefficients were found for the test performed in the one-foot standing test compared to the two-foot test. The results obtained indicate that particular attention in badminton training should be paid to the development of the level of postural stability in order to improve sports performance.
Distributed embodiment of metaphorical hope in hand, head, and eyebrow gestures
Authors: Khatin-Zadeh Omid , Farsani Danyal , Hu Jiehui , Farina Mirko , Banaruee Hassan , Marmolejo-Ramos Fernando
Published: March 2023

This study aimed to examine the embodied conceptualization of hope through metaphors. We asked a group of participants to discuss their hopes in a semi-structured interview. We examined the types of hand, head, and eyebrow gestures produced when they were talking about their future hopes. The obtained results showed that when participants talked about their future hopes, they mainly used forward hand gestures, rightward head gestures, and upward eyebrow gestures. Based on these results, it is suggested that various semantic components and emotional associations of hope are metaphorically embodied in different manners in various parts of the body. The future aspect of hope is conceptualized as a forward movement and is embodied as a forward hand gesture. The good or positive emotional aspect associated with future hopes is metaphorically conceptualized as a rightward head gesture or an upward eyebrow gesture. We call this process distributed embodiment of a metaphorical concept. Our proposal is supported by the findings of past studies that have found future is metaphorically embodied as something in front of us (or forward movement), and good is metaphorically embodied as upper space (or upward movement) or right side (or rightward movement).