bluuebunny/crossref_metadata_2025 huggingface dataset:
The Course of Glaucoma in Recovered COVID-19 Patients
Authors: Sevimli Neslihan , Saygın Işılay Özsoy , Saygın Efe
Published: November 2022

Purpose

To observe the course of glaucoma progression after coronavirus disease 2019 (COVID-19) treatment of patients with a previous history of glaucoma.

Design

Multicentric observational case-control study

Materials and Methods

This observational case-control study included total 74 patients with COVID-19 infection who were diagnosed with glaucoma previously. The study focused on the left eye of 37 patients each were treated as inpatient or outpatient. Age, gender, existence of systemic and ocular diseases, symptoms, laboratory results, drugs used for COVID-19 and glaucoma, length of hospital stay, intraocular pressure (IOP), and central corneal thickness (CCT) values were recorded. Peripapillary retinal nerve fiber layer thickness (ppRNFLT), ganglion cell–inner plexiform layer complex thickness (GCIPLT) and vertical cup-disc (C-D) ratio results were compared before (pre-COVID-19) and after (post-COVID-19) COVID-19 treatment in both groups.

Results

A significant increase was observed in IOP values in both inpatient and outpatient groups (p = 0,02, p < 0,01 respectively) after COVID-19 infection. However, mean difference (MD) was higher in inpatient group for IOP levels (-1,76). Inpatient and outpatient groups showed statistically significant decrease in GCIPLT values post-COVID-19 (p < 0,01 and p = 0,02, respectively). In addition, MD value was higher in inpatient group (2,72). A significant decrease was observed in ppRNFLT values in inpatient group after COVID-19 infection (p = 0,03). In both groups, the mean C-D ratio was higher post-COVID-19.

Conclusion

PpRNFLT and GCIPLT values were reduced and IOP and C-D ratio values were increased in glaucoma patients after COVID-19 infection. Infection progression observed to be worse in inpatient group.
Optimizing the performance of the neural network by using a mini dataset processing method
Authors: chen Jingliang , wu chenchen , Li hao
Published: November 2022

Data processing is one of the essential methods to optimize the performance of neural networks. In this paper, we give up the traditional data processing method and propose a method to optimize the deep neural network by processing the mini data set based on the loss. Using this method, each Literation training can obtain a relatively optimal result, and the optimization effects of each time are integrated to optimize the results of each epoch finally At the same time, in order to verify the effectiveness of this data processing method, experiments are carried out on MNIST, HAGRID, and CIFAR-10 datasets to compare the effects of using this method and not using this method under different hyperparameters, and finally, the effectiveness of this data processing method is verified. On this basis, the advantages and disadvantages of this method are summarized. Finally, the future research direction has been prospected.
Repair of aged restorations made in direct resin composite – A Systematic Review
Authors: Furtado Marcieli Dias , Immich Felipe , Rosa Wellington Luiz Oliveira da , Piva Evandro , Silva Adriana Fernandes da
Published: November 2022

Objective: to evaluate the different bonding strategies for repairing aged resin composite restorations.
Materials and Methods: The review was reported according to PRISMA Statement and registered in the Open Science Framework (DOI:10.17605/OSF.IO/WZTGS). Two reviewers performed a literature search across Embase (758), Pubmed (1244), Scopus (4300), The Cochrane library (128), and Web of Science (2538) databases. The risk of bias was assessed according to random sequence generation, blinding of outcome assessment, incomplete outcome data, selective reporting, coefficient of variation, and other bias.
Results: Forty-four in vitro studies with different repair strategies on aged resin composite substrates were included from 1990 up to July 2022 which evaluated superficial treatment using shear, flexural, tensile, and bond strength tests. The most frequent treatments were diamond bur and air abrasion. Meta-analysis showed an overall effect significant to diamond bur (shear test; p = 0.02), air abrasion (shear; p = 0.009; flexural, p = 0.003; tensile; p = 0.004 tests), and to phosphoric acid (tensile test, p < 0.00001).
Conclusions: Within the limitations of this study, strategies for improving bond to aged composites may consider better bond using air abrasion or diamond burs, and surface etching with phosphoric followed by the application of an adhesive system. Clinical Significance: This review presents the best treatments for performing the repair on aged resin composite, as guidance for clinical studies to improve emphasis on these findings, with the aim of creating a protocol that will enable dentists to promote minimally invasive treatments.
Clinical Significance: This review presents the best treatments for performing repair with resin composite, as guidance for clinical studies to improve emphasis on these findings, with the aim of creating a protocol that will enable dentists to promote minimally invasive treatments.
Assessment of a deep-learning system for colorectal cancer diagnosis using histopathology images
Authors: Kar Purna , Rowlands Sareh
Published: November 2022

Colorectal Cancer is the one of the most common forms of cancer hence, an early and accurate detection is crucial. Manual diagnosis is a tedious and time-consuming job which is prone to human errors as it involves visual examinations of pathological images. Therefore, it is imperative to use computer-aided detection (CAD) systems to interpret the medical images for a quicker and more accurate diagnosis. The traditional methods for diagnosis comprise extraction of features based on texture, pattern, illumination etc. from pathological images and then use these features in a Machine Learning model for binary classification i.e., cancerous, or non-cancerous. Deep-learning approaches like the Convolutional neural networks (CNNs) have proved to be very effective in classifying and predicting cancer from pathological images. In this study, we have assessed several CNN-based techniques for cancer diagnosis on digitized histopathology images. We have also compared the results of traditional methods for diagnosis with the deep-learning models. Moreover, we have proposed a new model by borrowing the idea from Xception architecture (Xception+), which outperforms the existing architectures. Furthermore, we have studied the effect of transfer learning technique by using models pre-trained on unrelated histopathology images.
Cytotoxic and Apoptotic Effects of Olive Leaf Extract Chitosan Nanoparticles on Breast Cancer MCF-7 and Lung Cancer A549 Cells
Authors: Özdamar Burcu , Sürmeli Yusuf , Mohamed Gülşah Şanlı
Published: November 2022

I. Background
Chitosan, which is a biocompatible and nontoxic material, is predominantly used as a polymer having the ability to nanoparticle formation. In this work, we immobilized olive leaf extract (OLE) with chitosan nanoparticles (CNPs), and elaborately characterized the OLE-CNPs. Also, the cytotoxic influence, the cell cycle distribution, and apoptosis stage of OLE and OLE-CNPs were analyzed on lung carcinoma (A549) and breast adenocarcinoma (MCF-7).
II. Methods and Results
OLE-CNPs were characterized by Zetasizer Nano-ZS and FT-IR Spectrometer. The cytotoxic effects of OLE-CNPs were performed by MTT assay, and cell cycle distribution and apoptotic effects of OLE-CNPs were carried out by using flow cytometer. The loading capacity and the size of OLE-loaded nanoparticles were found as 97.5% and about 100 nm, respectively, in the optimum conditions. In addition, OLE-CNPs were characterized by unique FTIR peaks and morphological display compared to the CNPs. In vitro cytotoxic assay indicated that IC50 values of OLE-CNPs were determined as 540 µg/mL for A549 and 810 µg/mL for MCF-7. The treatment of both A549 and MCF-7 with OLE-CNPs caused the highest cell arrest in G0/G1 in a dose-independent manner. OLE-CNPs affected cell cycle distribution different from free OLE treatment in both cancer cells. A549 and MCF-7 cells were predominantly found in the late apoptosis and necrosis phase, respectively, upon treatment of 1000 µM OLE-CNPs.
III. Conclusions
Our results suggest that CNPs enhance bioavailability OLE as nutraceuticals in cancer and OLE-CNPs might be offered as supplements for cancer therapy.
Fractal characterizations of MeV ion fractured CaF2 thin films
Authors: Pandey Ratnesh Kumar , Yadav Ram Pratap , Kumar Tanuj , Kumar Ashish , Pathak Sachin , Awasthi Shikha , Singh Udai B , Pandey Avinash C
Published: November 2022

We present the morphological evolution and fractal characterization of CaF2 thin film surfaces modified by bombardment with 100 MeV Au+8 ions at various fluences. Atomic force microscopy (AFM) combined with line profile and two-dimensional power spectral density (2D-PSD) analysis was utilized to investigate the evolution of surface morphology as a function of fluence. The AFM images were utilized to investigate the relationship between fractal dimension, roughness exponent, lateral correlation length, and ion fluence. The surface erosion owing to sputtering was depicted using Rutherford backscattering spectrometry (RBS). The structural characteristics’ dependency on fluence was explored with the help of glancing angle X-ray diffraction (GAXRD) measurements on virgin and irradiated samples. Tensile stress calculated using peak shift in the glancing angle X-ray diffractogram showed an increase in tensile stress with fluence that caused the surface to crack after the fracture strength of the surface was crossed. 2D-PSD analysis signified the role of sputtering over surface diffusion for the observed surface modifications. Fractal dimensions first increased and then decreased with ion fluence. Lateral correlation length decreased while roughness exponent increased with fluence after the threshold value.
A tissue-hybrid right ventricular pulsatile circulatory simulator with a functional tricuspid regurgitation
Authors: Takada Jumpei , Morimura Hayato , Hamada Kohei , Okamoto Yusei , Mineta Shiho , Tsuboko Yusuke , Hattori Kaoru , Iwasaki Kiyotaka
Published: November 2022

We hypothesize that the development of a pulsatile circulatory simulator with physiological morphology of tricuspid valve (TV) and right ventricle is essential to evaluate the performance after tricuspid valvuloplasty. This study aimed to develop a tissue-hybrid pulsatile circulatory simulator with clinically relevant tricuspid regurgitation (TR) to evaluate the effects of tricuspid annuloplasty. The tissue-silicone hybrid model consisted of a porcine TV sutured to a silicone right ventricular model with enlarged annulus, which can be pulsated while maintaining the relative position between the TV annulus and papillary muscle. The annulus of porcine TV was enlarged by degrading collagen fibers (pre- and post- annular perimeter 115.7 ± 5.5 vs. 133.1 ± 8.2 mm; p = 0.036). Severe TR models were successfully produced (pre- and post- regurgitation 0.64 ± 0.22 vs. 3.1 ± 0.59 L/min p = 0.0002). After the TV annuloplasty, regurgitation was reduced to a clinically mild grade (pre- and post-regurgitation 3.1 ± 0.59 vs 1.2 ± 0.27 L/min p = 0.013). The regurgitant jet in TR models was remarkably reduced after the annuloplasty. The novel tissue-hybrid system was useful to simulate severe TR and quantify the effects of the annuloplasty. The simulator would be useful to evaluate efficacy of emerging medical treatments and optimize them.
Overpartitions into distinct parts
Authors: Nadji Mohammed Lamine , Ahmia Moussa
Published: November 2022

We discuss a restricted overpartition, called overpartitions into distinctparts, by exploring its combinatorial and arithmetic properties, as well as providingboth generating function and bijective proofs, we also present some of its identities,beside a few congruences and asymptotic approach, the second part of this paperwill be about some new results on partitions and overpartitions.
Can the delta neutrophil index differentiate bacterial infection without bacteremia from viral infection in pediatric febrile patients?
Authors: Kim Maro , Lee Jin Hee , Kwak Young Ho , Kim Hyun Kyung , Kwon Hyuksool , Suh Dongbum , Kim Do Kyun , Lee Ha Ni , Kim Jin Hee , Jue Jie Hee , Hwang Soyun
Published: November 2022

Introduction
The delta neutrophil index (DNI) is a reported marker that can be used to predict the diagnosis, prognosis, and disease severity of bacteremia and sepsis.
We determined whether the DNI is useful in differentiating bacterial infection without bacteremia from viral infections in pediatric febrile patients in the emergency department (ED).
Method
This study involved a retrospective analysis of patient medical records from the pediatric ED of the teaching hospital. After extracting the list of patients with complete blood count (CBC) and DNI data,patients with bacterial infection (BI) without bacteremia and those with viral infection (VI) were identified.
The primary outcome was the diagnostic performance of DNI in differentiating BI without bacteremia from VI. The secondary outcome was a comparison of the diagnostic performances of DNI, CRP, WBC, and neutrophil count between the two groups.
Results
After excluding 756 patients, a total of 574 patients were included in the study. A total of 151 (26.3%) patients were in the BI group, and 423 (73.7%) were in the VI group. There was no significant difference in DNI between the two groups (3.07 (2.52~3.63) vs. 3.51 (2.40~4.62), mean (95% CI), BI vs. VI). There was no difference in WBC count, neutrophil levels, or RDW between the two groups, but CRP levels were significantly higher in the BI group than in the VI group (1.39 (1.19~1.60) vs. 4.56 (3.66~5.45), mean (95% CI), VI vs. BI, p < 0.05). The AUROCs achieved in analyses of DNI, WBC count, neutrophil levels, RDW, and CRP levels were 0.5016, 0.5531, 0.5631, 0.5131, and 0.7389, respectively, and only CRP levels were helpful in differentiating BI from VI.
Conclusion
In the absence of bacteremia, DNI wound not be helpful in differentiating BI from VI in pediatric febrile patients.
Evaluation of Lablab (Lablab purpureus L.) genotypes for Fodder production and their Nutritive Values for low lands of Southwest Ethiopia
Authors: Aleme Melkam , Mengistu Gezahegn , Tulu Dereje , Bogale Ararsa , Dejene Mesfin
Published: November 2022

The study was conducted to evaluate thirteen pre-screened lablab purpureus (L) genotypes out of ninety eight genotypes that introduced from ILRI Addis Ababa, Ethiopia for their potentials on dry matter and forage yield and also chemical compositions and in-vitro dry matter digestibility under lowland conditions of South West Ethiopia. The experiment was performed in three locations for two consecutive years during 2018–2019 and 2020–2021 cropping season. It performed by using completely randomized block design with three replications and analyzed by using SAS software version 9.3. Dry matter yield was significant (p < 0.001) whereas, seed yield was not significant (p > 0.05) among the genotypes. The second level interaction effect genotype-year-location was not significant (p > 0.05) for both dry matter and seed yield. However, the first level genotype-location interaction effect was significant at (p < 0.001) for dry matter and (p < 0.05) for seed yield. Those show that the genotypes vary in performances across the condition of study location. Genotypes indicated in T6 and T8 were better yield advantage for dry matter and seed yield with 72.1% and 21.1% and also 62.2% and 8.9% over the standard check (Gebisa) respectively. The stability of genotypes was estimated using the mean yield of genotypes (xi), regressing coefficient (bi) and regression deviation mean square (s2di). Stability analysis shows that even though the better stable genotypes are 11613 and 10953 genotypes in terms of dry matter yield, 11619 and 14459 were the most stable in terms of seed yield. These suggest that better performed and stabile genotypes need to be further evaluated on live animal performance through feeding trials including other agronomic activities for better production and productivity.
New Binary Sequences with Low Odd Correlation Via Interleaving Technique
Authors: Liu Bing , Qi Yanfeng , Tang Chunming , Yang Yang
Published: November 2022

Even correlation and odd correlation of sequences are two kinds of measures for their similarities. Both kinds of correlation have important applications in communication and radar. Compared with vast knowledge on sequences with good even correlation, relatively little is known on sequences with preferable odd correlation. In this paper, a generic construction of sequences with low odd correlation is proposed via interleaving technique. Notably, it can generate new sets of binary sequences with optimal odd correlation asymptotically meeting the Sarwate bound.
Mathematics Subject Classification: 11B50, 11B65, 11B83.
Coastscapes for a Metaverse: From height maps to virtual vegetated environments
Authors: Gross Felix , Petersen Lennart , Wallmeier Carolin , Karstens Svenja
Published: November 2022

Communicating environmental changes and scenarios to stakeholders and decision-makers can be challenging. Immersive environments offer a novel tool to transfer knowledge and allow the interactive discussion of scenarios. With the increase of space- and airborne remote sensing and coherent classification of ecosystems, many large-scale geospatial datasets are produced. Virtual environments can play an important role in conveying and discussing the findings gathered from these datasets. However, textured meshes and point clouds directly imported to a virtual reality are not always suited to create a truly immersive environment and often poste geometrical artifacts, which are miss-interpreted during the import to a game engine. In our study, we use an asset-based approach to create an immersive virtual representation of a coastscape. The focus hereby is on the coastal vegetation and changes in species distribution, potentially triggered by climate change impacts. We present an easy-to-use blueprint for the game engine EPIC Unreal Engine 5. In contrast to traditional virtual reality environments using static textured mesh data derived from photogrammetry, this asset-based approach enables the use of dynamics and physical properties (e.g. vegetation moving due to wind or waves) which makes the virtual environment more immersive.
Neutrino-induced Charged Current Electroweak Transition from Lambda-to Sigma-hyperon
Authors: Sheka Mohammed Jouhar , Adera Gashaw Bekele
Published: November 2022

In this paper, we present a fully relativistic description of charged current (CC) neutrino-hyperon scattering process near and above the threshold energy. The main focuses were the evaluations of the invariant matrix element (IME) and differential cross section (DCS) within the framework of the Glashow-Weinberg-Salam (GWS) model. By employing the standard model the exact expression of leptonic tensor in semi-leptonic electroweak interactions was determined. However, the hadronic tensor involves a vertex which is not fully understood by the electroweak theory since hyperons are composite particles. As such, hadronic vertex was parameterized by three unknown form factors to account for the effects of strong interaction. Then the unknown form factors were determined in the framework of the Cabibbo V-A theory and SU(3) symmetry. The angular distributions show that the DCS attains its peak near the forward scattering angles, whereas the energy distributions of the DCS indicate that dominate contribution comes from incident energies near the threshold energy. Based on our results, the quasielastic CC process under study can be considered as an intermediate energy phenomena as its DCS tends to vanish in high energy region.
Segmentation of COVID-19 lesions on computed tomography images: An approach using U-Net and pre-processing techniques
Authors: Marques Júlio , Ferreira José , Veras Rodrigo , Araujo Flavio , Carvalho-Filho Antonio , Silva Romuere
Published: November 2022

COVID-19 is an infectious disease caused by the novel coronavirus (SARS-COV-2). The global number of cases and deaths totaled 587 million and 6.4 million in August 2022. As this disease is highly contagious, the diagnosis must be made at its early stage to take necessary measures, including isolating the patient. In addition to the diagnosis, it is also essential to identify how this disease presents itself in patients, observing the involvement of the lungs. With this, it is possible to follow the evolution of this disease in the patient. Thus, we present a segmentation approach using U-Net, combined with a pre-processing and data augmentation methodology. In this work, we used several experiments where the K-Fold represents the best evaluation method. The methodology proposed in this experiment obtained the following metrics: 78.40% ± 0.05 from Dice, 64.80% ± 0.07 IoU, 78% ± 0.07 Sensitivity, and 100% ± 0.00 Specificity.
Microglia-derived exosomal miR-302a-3p suppresses ferroptosis to alleviate cerebral ischemia/reperfusion injury by inhibiting neuronal ferritinophagy via regulating the Keap1/Nrf2 axis
Authors: Yu Zhengtao , Zhuo Yi , Peng Jun , Li You , Jiang Junwen , Zhang Jikun , Xia Ying , Wang Lei
Published: November 2022

Objective: Recently, the protective effect of exosomes on ischemia/reperfusion (I/R) injury has become a research hotspot. The purpose of this study was to explore the therapeutic potential of microglia-derived exosomes on cerebral I/R injury.
Methods: BV2 cell-derived exosomes (BV2-Exo) were extracted and characterized. The cerebral I/R model was constructed in vivo and intervened by using exosomes loaded with miR-302a-3p. The oxygen and glucose deprivation (OGD) model was constructed in vitro to simulate cerebral I/R injury. The binding sites of miR-302a-3p to Keap1 were analyzed by bioinformatics prediction and confirmed by dual-luciferase reporter assay. A study of whether exosomal miR-302a-3p affected cerebral I/R injury via the Keap1/Nrf2 axis was carried out by overexpression of keap1 (oe-keap1).
Results: Experimental results in vivo showed exosomal miR-302a-3p significantly repaired the cognitive impairment and suppressed the apoptosis of hippocampal neurons induced by cerebral I/R injury. Besides, exosomal miR-302a-3p inhibited the expression of ferroptosis-related proteins NCOA4, PTGS2, and p53 in cerebral I/R-treated mice. Bioinformatics prediction and double-luciferase reporter assay showed that Keap1 was the direct downstream target of miR-302a-3p. Experiment results in vitro showed that oe-Keap1 reversed the therapeutic effect of exosomal miR-302a-3p on cerebral I/R injury via the Keap1/Nrf2 axis, promoting the high expression of NCOA4, PTGS2, and p53 and the increase of Fe2+, MDA and ROS levels.
Conclusion: The results demonstrated that microglia-exosomal miR-302a-3p suppressed ferroptosis to alleviate cerebral I/R injury by inhibiting neuronal ferritinophagy via regulating the Keap1/Nrf2 axis.
Multi-innovation gradient estimation for multivariate systems with colored noise based on the maximum likelihood principle
Authors: Liu Lijuan
Published: November 2022

The parameter estimation problems of the multivariate equation-error systems whose outputs are contaminated by an autoregressive noise process are studied by using the maximum likelihood principle and the coupling identification concept. The key is to decompose the system into several regressive identification subsystems based on the number of the outputs. By means of the negative gradient search, a multivariate coupled maximum likelihood generalized stochastic gradient algorithm is derived. In order to improve the parameter estimation accuracy, a multivariate coupled maximum likelihood multi-innovation generalized stochastic gradient algorithm is proposed by introducing the multi-innovation identification theory. The simulation example indicates that the proposed methods work well.
A tentative view on the GNSS receiver measurements
Authors: Xinli Zhou
Published: November 2022

In order to understand a problem in the ranging of GNSS receiver, by analyzing the starting point of the actual propagation distance of satellite signals in space, select a sufficient number of known geodetic coordinate points in a large range on the ground, and use the same number of GNSS receiver to conduct synchronous observation of more than four satellites in the sky. Conducting correlation analysis on the three coordinate axis direction errors ⊿x, ⊿y, and ⊿z of the GNSS three-dimensional rectangular coordinate value of this batch of known points, thus obtaining a tentative view that the GNSS range finding should actually take the spatial coordinates of the satellite when the receiver receives the satellite signal as the starting point!
WITHDRAWN: Non-Interference Pattern with Two Equal Maximum Intensities
Evolving to Interference Pattern with One Maximum Intensity
--- Novel Phenomena of Standard Double Slit Experiments
Authors: Peng Hui
Published: November 2022

The standard interpretation of Young’s double slit experiment is that the light behaves as waves before and after passing through the diaphragm of the double slit. There is one primary maximum intensity at the central position of the interference pattern. Recently, the photon chamber has been proposed and utilized to study the behavior of photons near the detecting screen. The experiments show that the light, near the screen, behaves as photons propagating along the straight-line trajectories that distribute as waves. Furthermore, the photon chamber placed near the double slit shows non-interference pattern.
In this article we show how the non-interference pattern evolving gradually to the interference pattern: (1) at 50 mm from the diaphragm of the double slit, the non-interference pattern shows and has two primary maximum intensities (Figure on left); (2) at 150 mm, there are two shape-changed maximum intensities (Figure at middle); (3) at 400 mm, the non-interference pattern evolves to the regular interference pattern (Figure on right). Those phenomena provide information for theoretical development.
Feature selection for software defect prediction using an improved firefly algorithm
Authors: Cao Lianglin , Ben Kerong , Zhang Xian , Song Li , Yang Jiahui , Peng Hu
Published: November 2022

As all we know, the performance of the data-based learning models heavily depend on the quality of data that feature selection (FS) method is used to reduce the redundant features and irrelevant features to improve the classification performance. In this research, a feature selection method using an improved firefly algorithm (FA) is proposed to address the "curse-of-dimensionality" problem in software defect prediction (SDP). In the proposed method, where simulated annealing (SA) approach is used to avoid falling into local traps, a multi-group strategy is employed to obtain a promising optimal solution to the optimization problems, called the multi-group simulated annealing firefly algorithm (MSAFA). To evaluate the performance of MSAFA, excessive experiments have been conducted on a total of 28 optimization benchmark problems (CEC2013) and 6 class-imbalanced datasets selected from the NASA repository. In the comparison with other state-of-the-art swarm-based intelligence algorithms, MSAFA outperforms them to provide the optimal solutions to most optimization problems and SDP models. In short, the proposed feature selection method can obtain the promising solution to support data-based classified models in SDP
DIGITAL MARKETING : STRATEGI PROMOSI APOTEK SAWOJAJAR MAS
Authors: Yuwana Siti Indah Purwaning
Published: November 2022

The rapid development of information technology has an impact on business activities ranging from small to large scale which requires utilizing sophistication in running their business. Innovative promotional strategies using the right media are needed to reach the market and increase sales volume. Digital Marketing is present as a marketing medium that is currently in great demand by all people. Sawojajar Mas Pharmacy is a business that sells medicines, foodstuffs and medical devices located in Malang City. The COVID-19 pandemic has limited visits to pharmacies, because it reduces physical contact with consumers. Of course this has a significant impact on sales turnover. To optimize sales volume, Sawojajar Mas Pharmacy utilizes online marketing and sales with various applications. This study aims to analyze how the promotion strategy carried out by Sawojajar Mas Pharmacy uses Digital Marketing to expand the market, increase sales turnover and attract new consumers. The research method in this study used a descriptive qualitative approach. Data collection uses 3 techniques, namely interviews, documentation and participant observation. Interviews were conducted with 3 informants who were appointed as resource persons. The results of the study explain that Sawojajar Mas Pharmacy as one of the pharmaceutical businesses in Malang City has succeeded in using Digital Marketing as an effective promotional tool, by utilizing social media, where its implementation provides enormous benefits for the company's marketing strategy.
AN EXPLORATION OF PUBLIC ADMINISTRATION IN PLANNING SUSTAINABLE DEVELOPMENT GOALS THE ROLES EXPECTED BY THE COMMON CITIZENS
Authors:   Faculty of Management Studies (FMS), Dept. of Public Administration Islamic University In Uganda, IUIU Mbale Main Campus, Mbale, Eastern Uganda., Shamsuddin Bolatito Aina-Obe
Published: November 2022

Sustainability is a philosophy associated with the long-run maintenance or improvement of human welfare and the preservation of natural capital and environmental integrity which public administrator needs to strengthen the Sustainable development goals (SDGs) an action directed by the philosophy of sustainability and is increasingly supported, promoted, and required by government actors and non-government actors to play a crucial role in the development of public beneficial programs by the United Nation. As the SDGs are critically receiving increased attention in public administration theory and practices, it has been accepted and tested to be promoting environmental well-being, while also improving the well-being of citizens. Can sustainable development goals promotes the well-being of the common citizens and citizenry participation in the implementation of SDGs and what be the expected concerns of the public administrators? This paper considers these questions by exploring case studies in which the application and practices of SDGs are integrated into public decision making. It also discusses the role expectations of sustainable development in public risk management and in promoting social justice through the use of UN approaches to life and environmental betterment programs.
FISTULOPLASTY FORFAILING AVF - AN INSTITUTIONAL EXPERIENCE
Authors:   Assistant Professor, Institute Of Vascular Surgery, MMC, Chennai., Mch Ramya , Mch Jayachander ,   Professor, Madras Medical College, Chennai., Ephreme Noble Collins ,   MCH Vascular Surgery Post Graduate, Madras Medical College, Chennai., Venkateshwar R. ,   MCH Vascular Surgery Post Graduate, Madras Medical College, Chennai.
Published: November 2022

Introduction: Failing AVF can be salvaged by open surgical technique, percutaneous encdovascular or hybrid methods. In this study our institutional experience on balloon fistuloplasty is described. The objective is To investigate the effectiveness of endovascular balloon angioplasty to preserve the patency of failing hemodialysis arteriovenous fistulas (AVF). Materials And Method: 1. Period Of Study - 3 YEARS AUG 2019 TO AUG 2022 2. Total No Of Patients â€“ 20 3. Study method â€“ retrospective observational study Results: In a total of 20 patients 16 cases (80%) were successful with immediate restoration of optimal flow rate during dialysis.At the end of 6 months â€“ 8 were successful. 5 had failed fistuloplasty, 3 â€“ expired. Conclusion:Fistuloplasty is a minimally invasive percutaneous procedure with established safety and efficacy to restore the normal function of AVF.Most common site is Cephalic V puncture sites. It is advised to follow Rope Ladder technique to avoid AVF failure.
PREDICTIVE FACTORS OF GOOD METABOLIC CONTROL IN CHILDREN WITH TYPE I DIABETES
Authors:   Pediatric Diabetes Unit, Childrens Hospital of Rabat., Saadaoui L. , Kebabi S. ,   Pediatric Diabetes Unit, Childrens Hospital of Rabat., Nahi C. ,   Pediatric Diabetes Unit, Childrens Hospital of Rabat., Tnacheri Ouazzani Z. ,   Pediatric Diabetes Unit, Childrens Hospital of Rabat., Benani N. ,   The House Of The Young Diabetic., Imane Z. ,   Pediatric Diabetes Unit, Childrens Hospital of Rabat.
Published: November 2022

Introduction: The management of children with type 1 diabetes has been revolutionized first by the discovery of insulin and then by the development of new technologies. Nevertheless, the majority of patients still do not reach their glycemic target. The main objective of this study is to determine the predictive factors of good metabolic control in children with type I diabetes, in order to develop tailored approaches to improve the quality of management and prevent disease-related complications. Materials and Methods : Prospective analytical and descriptive study spread over 6 years from January 2015 to January 2021 including type 1 diabetic children diagnosed between 2015 and 2019 and followed up at the House Of The Young Diabeticin collaboration with the diabetes department of the childrens hospital (P2). Clinical and epidemiological data were obtained from patients medical records and the Free diab database. Results :The number of patients meeting the inclusion criteria was 542. A mean A1C in the target range was associated in bivariate analysis with patient age (p=0.003), parental socioeconomic and academic level (p=0.001), adhesion to health coverage (p=0.001), initial HbA1C value (p=0.001), number of self-monitoring of blood glucose (p=0.001), and treatment regimen (p=0.001). In multivariate analysis, the association was statistically significant for 5 parameters: socioeconomic level ( ÃŸ 0.10 95%CI 0.10-0.26 p 0.03), parents academic level (ÃŸ 0.15 95%CI 0.24-0. 5 p=0.002), adhesion to health coverage (ÃŸ 0.12 95%CI 0.18-0.46 p=0.001), initial A1C level (ÃŸ 0.16 95%CI 0.15-0.38 p<0.001) and number of self-monitoring of blood glucose (ÃŸ 0.46 95%CI 0.21-0.3 p<0.001). Conlusion: Our study demonstrates parameters related to good glycemic control that need to be taken into account to develop new management strategies for children with type 1 diabetes.
A CASE REPORT OF GRANULOMA ANNULARE OCCURING IN UNBALANCED DIABETES: CLINICAL, DERMOSCOPIC, HISTOLOGICAL AND THERAPEUTIC FEATURES.
Authors:   Service de Dermatologie et Venerologie, Hopital Ibn Sina -Universite Mohammed V, Rabat, Maroc., S. Kerroum , C. Aitkhabba ,   Service de Dermatologie et Venerologie, Hopital Ibn Sina -Universite Mohammed V, Rabat, Maroc., Z. Zeggwagh ,   Service de Dermatologie et Venerologie, Hopital Ibn Sina -Universite Mohammed V, Rabat, Maroc., S. Darkaoui ,   Service dAnatomo-Pathologie, Hopital Ibn Sina - Universite Mohammed V, Rabat, Maroc., K. Znati ,   Service dAnatomo-Pathologie, Hopital Ibn Sina - Universite Mohammed V, Rabat, Maroc., M. Meziane ,   Service de Dermatologie et Venerologie, Hopital Ibn Sina -Universite Mohammed V, Rabat, Maroc., N. Ismaili ,   Service de Dermatologie et Venerologie, Hopital Ibn Sina -Universite Mohammed V, Rabat, Maroc., L. Benzekri ,   Service de Dermatologie et Venerologie, Hopital Ibn Sina -Universite Mohammed V, Rabat, Maroc., K. Senouci ,   Service de Dermatologie et Venerologie, Hopital Ibn Sina -Universite Mohammed V, Rabat, Maroc.
Published: November 2022

Granuloma annulare is a benign, inflammatory dermatosis of uncertain etiology, classically presenting with localized or generalized, skincoloured to violaceous, non-scaly, dermal papules/nodules which may be discrete or coalesce to form annular or roundish plaques. While granuloma annulare is a benign disease, little is known about its pathophysiology, etiology, and comorbidities. Furthermore, its treatment remains poorly standardized. This case of granuloma annular highlights the importance to look for associated diseases.
A STUDY TO ASSESS THE EFFECTIVENESS OF INTRADIALYTIC EXERCISE ON MUSCLE STRENGTHENING OF HEMODIALYTIC PATIENTS IN SELECTED HOSPITALS OF GANDHINAGAR
Authors:   Principal, Apollo Institute of Nursing, Gandhinagar., Mohan Singh Hari , Patel Hina ,   Assistant Professor Apollo Institute of Nursing, Gandhinagar.
Published: November 2022

A Quasi-experimental study was conducted to assess the effectiveness of intradialytic exercise on haemodialytic patients in selected areas of Gandhinagar. The study was conducted among the haemodialytic patients group in selected areas of Gandhinagar. The main aim of our study is to evaluate the effectiveness of intradialytic exercise on haemodialytic patients in selected areas of Gandhinagar. The general system model was used as conceptual framework. A quantitative approach with Quasi experimental study design was used to achieve the objective of the study. The study samples considered of 50 haemodialytic patients in selected hospitals of Gandhinagar. The observational checklist was used to assist the effectiveness of intradialytic on haemodialytic patients in selected areas of Gandhi The result shows that intradialytic exercise given to the haemodialytic patients in experimental group, the muscle strengthening improved which was assessed by observational checklist. In the experimental group, the pretest mean is 8.08 and posttest is 10.6, the mean difference was 2.52, standard deviation of pre-test was 1.87 and of posttest was 3.05 which showing that level of muscle strengthening was improved. In control group, the pre-test mean is 7.4 and the post-test is 7.12, the mean difference is 0.28, standard deviation of pre-test is 1.83 and of post-test is 1.94. Calculated value is 3.83 which is more than table value at level of 0.05 level of significance which showing effectiveness of intradialytic exercise. This study therefore, offers an encouraging solution towards improvement of muscle weakness and level of muscle strengthening score after administration of intradialytic exercise.nagar. The study intends to assess the effectiveness of intradialytic exercise on haemodialytic patients in selected areas of Gandhinagar. The study reveals that the post-testscore of haemodialytic patients on muscle strengthening is higher in the experimental group than the control group. It shows that Intradialytic exercise is more effective in experimental group so Null hypotheses is rejected and research hypotheses is accepted.
STUDY OF PATTERN OF ANTERIOR UVEITIS IN RURAL SET UP
Authors: Sharma Rashi
Published: November 2022

Introduction:Anterior uveitis includes iritis, iridocyclitis and anterior cyclitis. Aim of the study is to evaluate clinical profile of anterior uveitis in tertiary care centre in Western Maharashtra. Methodology:An observational ,descriptive , cross sectional study was conducted at tertiary care hospital in rural set up. A total 35 eyes of 27 patients diagnosed with anterior uveitis were evaluated. All patients underwent complete ophthalmic evaluation and systemic examination. Results:This study included 35 eyes of 27 patients. Anterior uveitis affected most commonly in people of age group of 5th and 6th decade. No gender predilection was seen. In majority of patients etiology was idiopathic (19 cases /70.37%) while of Rheumatoid Arthritis 2 cases were seen (7.40%). Majority of patients had non- granulomatous type of uveitis 91.42%. Unilateral presentation was seen in 70.37% of cases. Most common complication seen was complicated cataract seen in 7 eyes (20%).). Most of the eyes with anterior uveitis had cells of grade grade 2+( 37.14 %) and flare 1+ (28.57%). Conclusion:Anterior uveitis was most commonly observed in 5th and 6th decade of life. In most of the patients etiology was idiopathic. Acute anterior uveitis was most common common case presentation. Majority of patients of anterior uveitis had unilateral involvement and complicated cataract was the most common complication seen.
Predictive Factors of IT Systems Adoption by SME Employees in Developing Countries: Evidence from SME Employees in North Kivu, DRC
Authors: Kalumendo Rodrigue
Published: November 2022

This research aimed to identify the determinants of technology usage among SME employees in the North Kivu Province of the Democratic Republic of Congo. We based our model on the Technology Acceptance Model. In addition to perceived usefulness and ease of use, the proposed model includes relative advantage as a predictor of technology usage. This study used the PLS-SEM method to test the proposed hypotheses from 247 responses. The results confirmed the hypotheses. The research findings demonstrate a positive relationship between perceived usefulness and use, perceived ease of use and use, and relative advantages and use of new technologies. Congolese SME managers can rely on these findings to highlight these key determinants in promoting technology usage among SMEs in a country where technology usage by businesses remains low. Keywords: Perceived ease of use, Perceived usefulness, Relative advantages, SI adoption, Technology.
Access to Finance: The Determinants and Limitations to the Supply Side of Finance for Liberia’s Rural Market
Authors: Saye Gbatu Andy
Published: November 2022

This critical piece of research paper reviews the literature on the key determinants of finance for Liberia’s rural market. It also takes into account the limitations of the supply of finance for the rural market of Liberia, with the unabated need for the diversification of the Liberian economy in the face of intermittent shocks in the global economy. The study unearthed that investment in agricultural small and medium-sized enterprises (SMEs) will prove adequate in triggering sustainable economic growth and development through poverty alleviation, job creation, and food security which are the drivers of the supply of finance for rural dwellers in Liberia. Notwithstanding, the study found that the supply of finance for Liberian agricultural SMEs is constrained by the lack of creditworthiness information, weak judicial enforcement of contracts and corporate transparency, land ownership, high non-performing loans, and financial literacy. The keywords used in this article include gross domestic product, small and medium-sized enterprises, non-performing loans, inflation, credit rating, bankruptcy, value chain, urbanization, food security, human capital, and risk aversion. Keywords: Bankruptcy, Credit rating, Human capital, Inflation, Small and medium-sized enterprises, Value chain.
Drivers of Covid-19 Vaccine Hesitancy in Southern Nigeria
Authors: D.S. Adeniyi,
Published: November 2022

Hesitancy against the Covid-19 vaccines cuts across all nations of the world, but this may not be unconnected to the trolls of misinformation and politicization surrounding the Covid-19 science. Findings from this study reveal that 84.7% of the study population lacks adequate information about the Covid-19 vaccines. 50% of the study population is skeptical about the safety of the Covid-19 vaccines. 100% of the study participants make use of the internet and other social media platforms for their sources of news information. 55.3% of the study population would follow the advice of their healthcare workers pertaining to the Covid-19 vaccines. 26.7% of the study population would listen to instructions given by their parents pertaining to the Covid-19 vaccines, while 20.7% of the study population would follow the guidance of their religious leaders respectively. Thus, the main drivers of Covid-19 vaccine hesitancy in Southern Nigeria are a lack of correct information about the Covid-19 vaccines, misinformation on social media platforms, resistance from religious leaders and parents, and a lack of support for the Covid-19 vaccine uptake on the part of healthcare workers. It is, therefore, imperative that in order to overcome the present challenge, the population of Southern Nigeria should be educated on Covid-19 related subjects and engaged with health promotion initiatives. While accepting the Covid-19 vaccines by the hesitant populations in Southern Nigeria is largely dependent upon the attitudes and influences of religious leaders, parents, and healthcare workers, a much larger study is required to fully establish the ramifications of these important findings. Keywords: Covid-19, Healthcare Workers, Immunization, SARS-CoV-2, Southern Nigeria, Vaccine Hesitancy.
The Right оf а Person to Medical Care іn Ukraine
Authors: Prytyka Yurii , Nikitina Tetiana
Published: November 2022

Topicality. The relevance of the problem considered in the article is caused by the absence of the definition of the legal status of the participants in the relationships between the medical institution and the patient, as well as the object of this relationship, and the content of the “medical error” concept.
The purpose of the article. The aim of the article is to examine the legal status of the participants to the said relations (the medical professional and the patient), to determine the object of such legal relations and to define what constitutes the so-called “medical error”.
Research methods. The article provides a general overview of the legislation regulating the provision of medical services. The main features that characterize the person as a patient under the contract for the provision of medical services are determined. The practice of national courts is analyzed in the article in order to identify common problems with the application of legislation on compensation for damage caused by a “medical error”. Apart from that, the author focuses on the legal status of the parties to the agreement on the provision of medical services.
Results. The provision of medical care and services is aimed at the preservation of human life and health, which benefits not only the interests of the patient himself and his family members, but also in the long run the interests of the state and society as a whole. The relations between the medical institution and the patient are governed first and foremost by the norms of civil law, which means that legal disputes arising out of these relations (e.g. if the patient is harmed due to his physician’s failure to exercise due care) are considered as civil cases. The findings propose to determine the legal status of the healthcare professional and the patient, as well as to ensure the mandatory professional representation of patients in cases of “medical errors”.
Workshop untuk Meningkatkan Keahlian HCTS dalam Membuat Virtual Event
Authors:   Universitas Prasetiya Mulya BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia., Wibowo Andreas Christianto , Zahrandikaa Muhammad Raffi ,   Universitas Prasetiya Mulya BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia., Jayawardhana Irman ,   Universitas Prasetiya Mulya BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia.
Published: November 2022

Primary data was gathered from a group of stakeholders through direct interviews or online chat for those who are unavailable for such direct interviews. The objective of this research is to find the root problem that occurred during the 2020 HCTS as a virtual event held by Sun Eater, followed by a proposal of alternative solutions for said problems. The data collection is done with a qualitative research manner through the help of in-depth interviews with 2020 HCTS event personnels. The main problem was found to be “The lack of human resource skills in conducting an online event” by using the Severity and Urgency Matrix theory. The conceptual approach that was utilized during the construction of an alternative solution was the DMAIC, Event Management, and sub-domains knowledge of EMBOK theory.