bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytomorphological Profile of Graves' Disease and its Co-relation with anti-TPO Antibody
Authors:   Government Medical College, Haldwani, Nainital, Uttarakhand, India,, Shukla Sanjeev Kumar , Pant Prabhat , Singh Govind , Ahmad Shahzad
Published: June 2024

Objective: Thyroid diseases are major health problems in our society, which are manifested by alteration in hormone secretion, enlargement of the thyroid gland. FNAC plays a significant role in the diagnosis of thyroid lesions due to its simplicity and low cost and with a diagnostic accuracy rate of 92%. This study was designed to cytomorphological profile of Graves’ disease and its co relation with anti TPO antibody. Materials and Methods: This is a prospective analytical study of fifty patients with clinically enlarged thyroid gland presenting at STG Hospital, Haldwani, Nainital during Oct 2019 to Oct 2022. FNAC smears of these patients were studied and correlated with cytomorphological findings of different types, grades of thyroiditis and hormone level of T4, T3 and T.S.H. Results: Females were mostly affected by thyroid diseases than males. Female patients were 39 (78%) and male patients were 11 (22%). In the present study, patients were in the age group of 13 to 74 years of age. High T3 levels were noted in 80% high T4 levels were found in 90%. Low TSH level was found in only 64%, normal TSH level found in 34% and 2% presented with high TSH level. 34 patients (68%) found high anti-thyroid peroxidase antibody titre >34 U/ml. Cytomorphology revealed moderate to high cellularity in 88% cases, mild to moderate nuclear atypia in 86% and presence of marginal vacuoles in 82%. Lymphocytic infiltrate found in 24% cases and epithelioid cell granuloma in 14% cases. Conclusion: Thyroid cytology proves to be a reliable, simple, and cost-effective first-line diagnostic procedure with high patient acceptance and with rare, usually easily treated and not life-threatening complications. We recommend further studies with a larger population to validate our study. Keywords: Thyroiditis, Graves' Disease, Malignancy Goiter, Histopathology
A Cross-Sectional Study of Tumor Budding in Correlation with Clinicopathological Parameters in Invasive Breast Carcinoma
Authors:   Alluri Sitaramaraju Academy of Medical Sciences, 534005, Andhra Pradesh, Malla Swarupa , Suryadevara Sailaja , Umarani Pallivilla , Vahini Gudeli
Published: June 2024

Introduction: Breast carcinoma is the largest cause of mortality from cancer among women in India. Tumor budding is usually defined as isolated single cancer cells or clusters of up to four cancer cells located at the invasive tumor front. Tumor budding is associated with poor clinicopathological characteristics, such as Tumor size, tumor differentiation, lymph node invasion, lymphatic or vascular invasion etc. Aim: To study tumor budding and its association with known clinicopathological parameters and hormone receptor status in invasive breast carcinoma. Methods : A Cross-sectional study was conducted after approval from the ethics committee. The duration of study was 1.5 years (Jan 2022- June 2023). Results: A total of fifty cases of invasive breast carcinomas were included in this study. 70% (35cases) were >50yrs of age, 65% (33cases) were of T2 (tumor size) category. 82%(41cases) of Invasive duct carcinoma, No specific type, 12% (6 cases) of mixed carcinomas followed by three cases, one is invasive lobular carcinoma(6%), others are high grade papillary duct carcinoma(6%) and mucinous carcinoma (6%). 76%(38cases) showed presence of lymphovascular invasion, 74%(37cases) showed absence of necrosis, 54%(27 cases) are categorized as grade 2. High grade tumor budding was seen in 54% (27 cases). Conclusion: The following variables had a significant association with the tumor budding in present study: Tumor size, TNM staging, treatment status, lymphovascular invasion showing a p-value of <0.05. ER positive tumors are also associated with high grade tumor budding. Keywords: Breast Carcinoma, Clinicopathological Variables, Lymphovascular Invasion, Tumor Budding
Fostering Proficiency in Cell Identification: A Comparative Analysis of Diagrams and Microscopic Images for Optimal Cytopathology Learning in Competency Based Medical Education Curriculum
Authors:   Department of Pathology, S.S. Institute of Medical Sciences and Research Centre, NH4, Bypass Road, Davangere, 577005, Sreevidyalatha G M , Shashikala P
Published: June 2024

Background: Histopathology and Cytopathology are crucial aspects of medical education. With a paradigm shift from traditional to competency-based curriculum, teaching strategies are crucial to enable learning. we undertook a comparative analysis to evaluate the efficacy of two distinct teaching Learning tools—diagrams and microscopic images—in enhancing the observational and cognitive skills of medical students. Material and methods: A mixed method research design was planned to obtain quantitative data followed by qualitative data. These were later integrated for interpretation. A series of thirty microscopic images of cells, from topics already taught and diagrams of the same cells, drawn with Hematoxylin Eosin pencils, were projected to assess cell identification. Students were tasked with identifying and documenting their observations. The microscopic images were sourced from standard textbooks, while the diagrams were prepared by faculty and validated by subject experts. Responses were evaluated and scores analyzed using paired t-test. Focus group discussion was conducted to obtain qualitative data. Results: A group of 74 second-year medical students voluntarily participated in this study. Statistical analysis revealed that the scores for diagram identification were significantly higher than those for microscopic images, with a p-value of less than 0.05. Diagrams had a positive impact. Conclusion: Diagrams were superior to microscopic images in facilitating cell identification. This study underscores the importance of incorporating drawing-based teaching and learning methods in cytology as they encourage a more profound and effective learning process. Continued inclusion of diagrams in medical education to enhance students' cell identification skills is recommended. Keywords: Cytopathology, Curriculum, Medical Education, Drawing
Partially Empty Sella with Optic Disc Coloboma - Unique Association
Authors:   Department of Ophthalmology, KIMS Bhubaneswar, Patia, Bhubaneswar, Odisha, India, Sen Saswati , Dash Snehalata , Sidana Akash , Goel Anjali
Published: June 2024

Congenital anomalies in individuals, more often than not involve multiple organs. We present the case of a 26-year-old female who presented with headache and sleep disturbances as primary complaints. She was found to have a partially empty sella in association with iris and optic disc coloboma. Septo-optic dysplasia is commonly seen in patients with complete or partially empty sella where hypoplasia of optic nerve is seen. Association of iris coloboma and optic disc coloboma with partially empty sella has been reported rarely and was discovered in this patient. Keywords: Insomnia, Coloboma, Congenital Anomalies, Optic Nerve Head, Empty Sella
MENGINTEGRASIKAN KONSEP RAHMATAN LIL ALAMIN DALAM KURIKULUM PENDIDIKAN ISLAM DENGAN PENDEKATAN HOLISTIK
Authors: Ismail  , Tobroni  , Faridi
Published: June 2024

The concept of Rahmatan lil Alamin suggests that Islamic education can serve as a vehicle to improve human relations with nature, promote peace within society, and encourage sustainable spiritual and material development. This study aims to confirm the relevance of applying the concept of Rahmatan lil Alamin with a holistic approach at Madrasah Aliyah Muhammadiyah 01 Tegalombo. The research questions are formulated as follows: How does the integration of Rahmatan lil Alamin with holistic concepts manifest in the curriculum at Madrasah Muhammadiyah 01 Tegalombo? What are the implementation strategies for integrating Rahmatan lil Alamin with holistic concepts at Madrasah Muhammadiyah 01 Tegalombo? This qualitative research employs a case study approach. The findings reveal that Madrasah Aliyah Muhammadiyah 01 Tegalombo has successfully created an educational environment that is not only academic but also ethical and cultural. Their vision to produce academically and morally intelligent generations capable of being a mercy to all creation is reflected in their efforts to integrate Islamic values into the educational culture.
STRATEGI KUA KECAMATAN BANYUANYAR DALAM PENCEGAHAN PERNIKAHAN DINI
Authors: Rimawati  , Billah Ana
Published: June 2024

The purpose of this study is to analyze the strategic steps of the Banyuanyar District KUA to the community so that early marriage can be prevented by providing prevention efforts either through meetings with the community, especially women who have teenage children, or meetings or socialization to schools so that students understand early marriage. This study is a field study and uses a qualitative approach, and is analyzed descriptively. Data collection obtained directly based on the results of observations and interviews with sources at the location of a case or event being studied which was carried out directly by the researcher. The location of this research was carried out at the Banyuanyar District KUA office, Probolinggo Regency. The results of the study at the Banyuanyar District KUA are strategic steps in an effort to minimize or prevent early marriage which is carried out by providing a letter of rejection of early marriage. The Banyuanyar District KUA provides advice to prospective brides and grooms who are still underage so that there is no increase in early marriage. In implementing it, the KUA of Banyuanyar District provides direct socialization to teenagers in the form of character and mental development and training in order to reduce the high number of early marriages and additional funds are needed from the local government so that there is socialization of early marriage prevention either through the media or meetings in each region or area so that it can reduce or even suppress the number of early marriages.
Keywords:  Efforts; Prevention; Early Marriage.
The Effect Of Discounts And Word Of Mouth Communication On Purchasing Decisions At Src Al-Badar Wholesale Stores
Authors: Permana Romi , Nugraha Muhammad Rivaldhie Juniar , Amrullah Amir Arkhan , Misbak Misbak , Dedu May
Published: June 2024

Currently, the business world is very competitive, especially in Indonesia. This is shown by the increasing number of traditional businesses that are starting to transition to modern businesses, or perhaps new modern businesses. This study uses Quantitative Research, a research method that collects data in the form of numbers or numerical data to be analyzed statistically. The results of hypothesis testing show that the variable Price Discount, Word of Mouth simultaneously has a positive effect on consumer purchase decisions. From the partial results, the discount has a positive and significant effect on the purchase decision at the Al-Badr src graosir store. Simultaneously, discounts and word of mouth communication have a positive and significant effect on product purchase decisions at the Al-Badr src wholesale store.
LAW ENFORCEMENT AGAINST PERPETRATORS OF CHILD SEXUAL VIOLENCE
Authors: Jannah Lintang Nur , Apriliyanti Apriliyanti , Febriana Deby Wulandari , Hidayat Dudung , Rasta Gunadi
Published: June 2024

The definition of abuse (violence) is not only interpreted physically, but also mentally and even passively (neglect). It can be known, it is undeniable that on the other hand, Abuse in its implementation cannot be separated from the element of violence. Violence can be interpreted as wrong treatment, cruel treatment. In this regard, the problem is: how to enforce the law against sexual violence against children and how obstacles are to the implementation of law enforcement against sexual violence against children. The method used in this study uses a normative juridical method, namely research that focuses on finding legal norms, legal principles and legal doctrines to answer the legal issues to be studied. The results of this study found that the form of law enforcement used in this case uses a preventive method which prevents a person from committing a criminal act for the first time and also in the implementation of law enforcement there are still inhibiting factors that make the implementation of this law enforcement not run optimally, namely internal factors and external factors. Therefore, professional law enforcement is needed and also who can involve other stakeholders so that this law enforcement can run better.
Contextual-Based Development of Early Children's Learning In the Era of the Industrial Revolution 4.0
Authors: Rahmah Nur , Subhan Subhan , Nursyamsi Nursyamsi , Fitriani Fitriani , Nurliana Nurliana
Published: June 2024

The world has now entered the era of industrial revolution 4.0, or the fourth industrial revolution, where information technology has become the main basis in human life. This research aims to: (1) describe early childhood Islamic learning in PAUD Palopo City; (2) describe contextual learning; (3) find a factual model of contextual-based learning; (4) find a contextual development model (draft) of early childhood Islamic learning. This research is a development research (R&D). The research was conducted in PAUD Parama Bunda, Libukang Permai, and Aisiyah Bustanul Athfal Palopo City. Informants in this study were education managers, principals, educators, and related parties who supported the research data. Data collection techniques used in-depth interviews, participatory observation, and documentation studies. Retrieval and checking the validity of data using triangulation techniques, reviewing key informants, and checking with members. Data analysis techniques used data reduction, data presentation, and conclusion drawing. Early childhood learning in Palopo City PAUD generally refers to service standards in organizing PAUD learning. Contextual-based learning planning is prepared in the form of curriculum, syllabus, semester program, weekly learning implementation plan (RPPM), daily learning implementation plan (RPPH). In practice, this learning is integrated with contextual learning. The contextual learning model is presented to the stakeholders involved for feedback and suggestions for improvement. The factual model was then revised and enriched in the form of a development model (draft) to make it easier to implement.
Analysis of Factors in Reducing the Incidence of Anemia in Adolescent Girls at Ummi Kulsum Banjaran SMP Bandung District
Authors:   Immanuel Health Institute, Fuadah Fahmi , Saragih Berlina D ,   Immanuel Health Institute
Published: June 2024

Adolescence is a transition period from childhood to adulthood. In Indonesia, around 90% of women menstruate every month, but the onset of menstruation can cause anemia for teenagers who experience it. This is caused by several things, of course because there is irregular bleeding, this is caused by the teenager’s age itself. , parental factors, including education and work, each person’s food intake/nutritional status, and also the menstrual cycle/length of menstruation experienced each month. This research aims to determine the factors associated with the occurrence of anemia in adolescent girls at Umi Kulsum Banjaran Middle School in 2022. The research method used is a quantitative analytical approach research design with a cross sectional research design. The research population was all 120 female students and the sample used was 55 people using the random sampling technique. Data collection was carried out by means of interviews and direct examination of respondents. Data analysis went through three stages, univariate (frequency distribution), bivariate (chi square) and multivariate analysis (Logistic Regression). The results of the research show that there are factors that are associated with the incidence of anemia in adolescent girls, including age, nutritional status and length of menstruation with a p-value <0.05. It is recommended that students increase their knowledge about reproductive health, especially those related to enstruation, educational institutions can optimize education about adolescent reproductive health by collaborating with health workers in the surrounding environment.
Predictive Modeling in Remote Sensing Using Machine Learning Algorithms
Authors:   Dept of CSE, Crimson Institute of Technology, Hyderabad., Shaik Abdul Subhahan , Shaik Nazeer ,   Dept of CSE, Srinivasa Ramanujan Institute of Technology (Autonomous), Anantapur., Priya Dr. C. Krishna ,   Dept. of Computer Science & IT, Central University of Andhra Pradesh, Anantapur.
Published: June 2024

Predictive modeling in remote sensing using machine learning (ML) algorithms has emerged as a powerful approach for addressing various environmental and climatic challenges. This paper explores the integration of advanced ML techniques with remote sensing data to enhance predictive capabilities for applications such as land cover classification, crop yield prediction, climate change monitoring, and disaster management. We review related works and existing systems, highlighting platforms like Google Earth Engine (GEE), NASA Earth Exchange (NEX), and Sentinel Hub, which leverage cloud computing to handle large-scale data processing and model deployment. The proposed system incorporates data acquisition, preprocessing, feature extraction, model selection and training, and prediction and visualization to provide accurate and timely predictions. Future enhancements, including deep learning integration, real-time data processing, enhanced user interfaces, and collaboration with Internet of Things (IoT) devices, are discussed to further strengthen the system’s capabilities. The paper concludes by emphasizing the potential of ML algorithms in transforming remote sensing applications, supporting informed decision-making, and improving the management of Earth’s resources.
Green Accounting, Financial Performance, and Company Value: A Bibliometric Study
Authors:   UIN Sunan Ampel Surabaya, Jl. Ahmad Yani No 117, Indonesia, Bagraff Halida Achmad , Ahsan Muhammad ,   UIN Sunan Ampel Surabaya, Jl. Ahmad Yani No 117, Indonesia
Published: June 2024

This research aims to examine the interconnection between green accounting, financial performance, and company value. This study employs a bibliometric approach utilizing bibliographic coupling and co-occurrence analysis, identifying 119 relevant articles on Scopus. The results reveal two prominent clusters, namely sustainability and sustainable development. Green accounting not only influences financial performance and company value but also has the potential to impact sustainability and sustainable development. For companies to thrive, it is crucial to consider corporate interests and environmental sustainability. This research will benefit researchers and academics exploring the relationship between green accounting, financial performance, and company value.
HIGH ORDER ANTI EVEN LEAST SQUARE FOR APPROXIMATING PRIME NUMBERS BELOW 1000
Authors:   Department of Mathematics, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia, Henindya Permatasari Anindita , Dian Pratama Jovian ,   Department of Mathematics, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia
Published: June 2024

The study of prime numbers, pivotal in mathematics for centuries, holds significant importance in number theory and diverse applications like cryptography and computer science. This article introduces a novel approach, "High Order Anti Even Least Square," for approximating prime numbers below 1000. Integrating Least Square with specialized techniques tailored to complex prime number distributions, this method aims to enhance accuracy compared to traditional approaches. The research methodology involves polynomial approximation using both traditional and anti-even least squares methods, error calculation, visualization, and analysis. Results indicate that while traditional least squares generally performs better, the anti-even least squares method shows promise, particularly at higher polynomial degrees. This study contributes to advancing number theory and its practical applications by presenting a novel method for prime number approximation.
Understanding 30 Years of Integrated Marketing Communication (IMC) in the 2019 Indonesian Journal
Authors:   Faculty of Communication Sciences, Universitas Pancasila, Jakarta, Estaswara Helpris , Said Mashadi ,   Faculty of Communication Sciences, Universitas Pancasila, Jakarta
Published: June 2024

This article examines 10 journals on Integrated Marketing Communication (IMC) in Indonesia in 2019. Essentially, IMC consists of two core concepts, which have evolved into four stages of IMC implementation. The first concept, introduced in 1989, is known as the inside-out approach or tactical coordination of marketing communications. The second concept, emerging in 2004, is called the outside-in approach, encompassing internal support to external activities (Second Stage), application of information technology (Third Stage), and financial and strategic integration (Fourth Stage). Thus, this paper seeks to address: (1) What is IMC as described and applied?; (2) What communication elements are used?; (3) Is the brand the main message in the IMC program?; and (4) Is the IMC used inside-out or outside-in, and where are the boundaries? Using a systematic literature review method, the results indicate that IMC is marketing communication or promotion. The communication elements include advertising, personal selling, sales promotion, public relations, interactive marketing, corporate design, sponsorship, exhibitions, websites, merchandising, packaging, and social media. No articles used the brand as the main message in IMC, categorizing it as an inside-out approach since many did not involve the brand and only analyzed marketing communication or promotion. IMC in Indonesia does not align with the global development of the IMC concept but follows communication technology trends through the use of internet-based media, such as social media.
Analysis of BSF Maggot Farming Income in the Context of Organic Waste Management in NTB Province, Indonesia
Authors:   Faculty of Economics and Business, University of Mataram, Indonesia, Sulastri Gita , Diswandi Diswandi ,   Faculty of Economics and Business, University of Mataram, Indonesia
Published: June 2024

This study investigates the factors influencing the income of Black Soldier Fly (BSF) maggot farmers in the NTB province of Indonesia. Utilizing a descriptive quantitative analysis method, data were collected from 32 maggot farmers through purposive sampling. The primary data were obtained via questionnaires administered to the selected farmers. The analysis employed a multiple regression model to evaluate the impact of various factors on farmers' income. The results indicate that the average monthly income of BSF maggot farmers is Rp 5,938,750 (364.35 USD). The income is significantly influenced by the amount of production, production cost, and selling price. Specifically, an increase in production amount and selling price positively correlates with higher income, while an increase in production cost negatively affects income. These findings highlight the critical role of efficient production practices and market strategies in enhancing the economic viability of BSF maggot farming.
Resuscitation Guided by Cardiac Output using Transesophageal Echocardiography in Kidney Transplantation: Case Report.
Authors:   Critical Care Medicine and Anesthesiology Physician. Hospital Juarez de México, CDMX., Rodriguez Alfonso de Jesus Flores , Marines Karla Joselyne Manrique ,   General Surgery and High specialty in Abdominal Organ Transplant Surgery. Hospital Juarez de Mexico, CDMX., Cordero Angelica Mariana Salgado ,   Third year Anesthesiology Resident. Hospital Juarez de Mexico, CDMX., Camacho Mariana Elisa Guillen ,   Transplant Anesthesiology Physician. Hospital Juarez de Mexico, CDMX., Morelos Ricardo Daniel Romero ,   General Surgery and High specialty in Abdominal Organ Transplant Surgery. Hospital Juarez de Mexico, CDMX., -Espin Paulina Carpinteyro ,   General Surgery and High specialty in Abdominal Organ Transplant Surgery; Chief of Transplant Department. Hospital Juarez de Mexico, CDMX., Mondragón Xochitl Popoca ,   Anesthesiology Physician; Chief of Anesthesiology Department. Hospital Juarez de México, CDMX.
Published: June 2024

Introduction: During kidney transplant, monitoring fluid administration is essential to ensure graft function. Transesophageal echocardiography measures the impact of fluids/medications on real time at myocardium. Case Report: A 28-year-old female patient who underwent a kidney transplant with cardiac output resuscitation by transesophageal echocardiography: Initially, the patient presented a hypovolemic profile that responded to crystalloid infusion. By monitoring the cardiac output, fluid accumulation syndrome is avoided, leading to a distributive profile where the state of dynamic overload is physiologically de-escalated after reperfusion. Discusion: Cardiac output-guided resuscitation using transesophageal echocardiography ensures tissue perfusion without fluid accumulation in kidney transplant surgery.
Disseminated Superficial Actinic Porokeratosis: Case report
Authors:   Centro Médico Nacional 20 de noviembre, Lorely Montes-Flores Zyanya , Arely Luna-Salazar ,   Clínica de Oncodermatología UNAM, Nava Lucía-Achell ,   Centro Médico Nacional 20 de noviembre, Rosario Rosas- García Mariela ,   Clínica de Oncodermatología UNAM, Fernanda Pastrana-Otero María ,   Clínica de Oncodermatología UNAM, Xymena Dominguez-Navarrete ,   Clínica de Oncodermatología UNAM, Renata Dominguez-Navarrete ,   Clínica de Oncodermatología UNAM
Published: June 2024

Background: Disseminated superficial actinic porokeratosis is a rare disorder that presents abnormal clonal keratinization of unknown etiology. Frequently associated with UV radiation, genetic factors, and immunosuppression. It manifests clinically as solitary or multiple annular plaques surrounded by a hyperkeratotic border. Various clinical forms have been described, including disseminated superficial actinic porokeratosis, the most common subtype and represented in the following clinical case. Clinical case: A case of a 62-year-old male is presented who presents with dermatosis characterized by annular erythematosquamous plaques spread to the hands, chest and upper and lower extremities and chest with collarette scales of chronic evolution. A clinical diagnosis is made, confirmed by classic histopathology and dermoscopic findings. Conclusions. Disseminated superficial actinic porokeratosis is rare, difficult to diagnose and similar to multiple pathologies; This is why it is important to recognize them clinically and achieve timely treatment of potential malignancy that they present.
Functional and Aesthetic Outcomes in Facial Reconstructions with Multiple Composite Axial Flaps – Case Report
Authors:   “Carol Davila” University of Medicine and Pharmacy, Bucharest , Romania, EU &  Department of Plastic Surgery, “Bagdasar Arseni” Clinical Emergency Hospital, 12 Berceni Road, 041915, Bucharest, Romania, EU, Turcu Eugen Gabriel , Oltean Dan Alexandru ,   Department of Plastic Surgery, “Bagdasar Arseni” Clinical Emergency Hospital, 12 Berceni Road, 041915, Bucharest, Romania, EU, Branaru Matei Gheorghiu ,   Department of Plastic Surgery, “Bagdasar Arseni” Clinical Emergency Hospital, 12 Berceni Road, 041915, Bucharest, Romania, EU
Published: June 2024

The article presents a case of facial reconstruction with several facial axial flaps for a posttraumatic defect of the left upper lip, medial cheek region and left nasal wing. The case refers to a 58-year-old patient who is hospitalized for a facial trauma which involves only the soft tissues, resulting from a car accident.The immediate reconstruction of all the affected aesthetic units using multiple reconstructive techniques allowed the favorable resolution of the case in the shortest possible time. We used advancement and rotation orbicularis oris innervated musculocutaneous flaps for reconstruction of the left upper lip, cervicofacial cutaneous flap for the medial cheek defect and composite forehead flap for the reconstruction of the left nasal wing. The simultaneous use of different types of flaps made possible the total healing after 4 weeks after the accident and the social and professional integration of the patient.Complex facial trauma often involves both skeletal and soft tissue damage, presenting significant challenges in both initial management and long-term reconstruction. These injuries can result from various etiologies including motor vehicle accidents, assaults, sports injuries, and falls. Effective treatment requires a multidisciplinary approach to address the intricate anatomy and functional importance of facial structures.
Reassessing Antimicrobial Strategies: Antibiotics Outperform Nanoparticles in Controlling Bacterial Growth
Authors:   Department of microbiology, College of Veterinary Medicine, AL-Qasim Green University, Babylon 51013, Iraq., Abady Noor R , Mosa Ahmed Hamzah ,   Department of Internal and Preventive Veterinary Medicine, College of Veterinary Medicine, AL-Qasim Green University, Babylon 51013, Iraq., salman Abdul- Kareem ,   Department of microbiology, College of Veterinary Medicine, AL-Qasim Green University, Babylon 51013, Iraq, Muslim Zahraa A ,   Department of microbiology, College of Veterinary Medicine, AL-Qasim Green University, Babylon 51013, Iraq, Aljabory Hamed A. H. ,   Department of Internal and Preventive Veterinary Medicine, College of Veterinary Medicine, AL-Qasim Green University, Babylon 51013, Iraq
Published: June 2024

The purpose of this work was to investigate the possibility of using genetically modified E. coli as a platform for the large-scale production of metal nanoparticles (NPs) with particular morphological characteristics. Our findings defied the popular idea that nanomaterials always work better than traditional antibiotics by showing that antibiotics were more successful than nanoparticles at stopping the development of germs. Azithromycin, in particular, showed notable inhibitory zones in comparison to Ag-silver and silver nanoparticles. These results highlight the necessity of critically reevaluating the effectiveness of nanoparticles in antimicrobial applications and taking into account different approaches when intended results are not obtained. The demonstrated efficiency of conventional antibiotics underscores their ongoing significance.
The Influence of Health Education on Elderly Knowledge about Healthy Lifestyle Patterns at RW 08 Jayagiri Lembang Village
Authors:   Immanuel Health Institute, Fuadah Fahmi , Saragih Berlyna D ,   Immanuel Health Institute, Harun Irianti ,   Immanuel Health Institute, Purnasari Heni ,   Immanuel Health Institute, Sinaga Herwinda ,   Immanuel Health Institute
Published: June 2024

Knowledge about healthy lifestyles is an important factor that can influence the quality of life of the elderly. Health education is one intervention that can increase this knowledge. This research aims to determine the effect of health education on elderly people's knowledge about healthy lifestyles. This research method uses a quasi-experimental design with a pretest-posttest control group approach. The research sample consisted of 32 elderly people who were selected using purposive sampling and divided into two groups: an experimental group that was given health education and a control group that did not receive intervention. Health education was carried out through lectures, discussions and giving leaflets over four sessions. The results of data analysis using the Wilcoxon test showed a significant increase in knowledge about healthy lifestyles in the experimental group compared to the control group. The average knowledge score in the experimental group increased from 60.3 to 85.7 after the intervention, while the control group did not show a significant change. Health education has proven effective in increasing elderly knowledge about healthy lifestyles. This intervention can be a strategy in health promotion programs for the elderly. It is recommended that health education programs regarding healthy lifestyles be held more frequently and made part of routine services at community health centers or elderly communities. Apart from that, further research needs to be carried out to see the long-term influence of health education on changes in behavior and quality of life for the elderly
PEMILIHAN JENIS PELARUT EKTRAKSI PADA PENGUJIAN POTENSI ANTIBIOTIK NEOMISIN KRIM
Authors:   Balai Besar Pengawas Obat dan Makanan, Sachara Fuji , Prasetyo Budi ,   Universitas Terbuka
Published: June 2024

Neomycin krim merupakan obat antibiotik dalam bentuk campuran antara emulsi minyak dan air. Pada Neomycin krim perlu dilakukan pengujian secara mikrobiologi untuk mengukur efek senyawa terhadap pertumbuhan mikroba uji yang peka melalui proses ekstraksi menggunakan suatu pelarut agar zat aktif terpisahkan dari campurannya. Penelitian bertujuan untuk mengetahui pengaruh jenis pelarut (dietil eter, petroleum benzene, dan kloroform) terhadap kadar potensi antibiotik neomisin krim. Penelitian menggunakan metode eksperimental, terdiri atas tahapan ekstraksi (persiapan sampel) menggunakan metode maserasi melalui ektraksi cair-cair, dan tahapan penetapan kadar potensi antibiotik menggunakan metode lempeng-silinder. Hasil pengamatan ekstrak dari masing-masing pelarut menunjukkan bahwa ekstrak dari pelarut kloroform terpisah menjadi dua fase, yaitu fase terdispers (pelarut buffer) berwarna bening yang secara proposional berada pada bagian atas dan fase pendispers berada pada bagian bawah. Ekstrak petroleum benzene terpisah menjadi dua fase, yaitu fase terdispers berwarna putih yang secara proposional berada pada bagian bawah dan fase pendispers berada pada bagian atas, sedangkan pada ekstrak dietil eter terpisah menjadi dua fase namun tidak proposional, yaitu fase terdispers berwarna putih bening berada pada bagian bawah dengan porsi lebih banyak dibanding fase pendispers yang berada pada bagian atas. Hasil uji potensi menunjukkan pada ektrak kloroform diperoleh kadar potensi 97,15%, ekstrak dietil eter 80,88%, dan ekstrak petroleum benzene 45,78%. Dengan demikian, kadar potensi optimum diperoleh pada ekstraksi menggunakan pelarut kloroform.
Development of Optimized Strategy for Cloning, Expression and Analysis of a Recombinant Anti-CD20 Therapeutic Monoclonal Antibody in HEK-293 Cells
Authors:   National Institute of Biologicals, Ministry of Health and Family Welfare, Government of India, A-32, Sector-62, Noida, 201309, Uttar Pradesh, India, Kasana Harit , Chander Harish ,   National Institute of Biologicals, Ministry of Health and Family Welfare, Government of India, A-32, Sector-62, Noida, 201309, Uttar Pradesh, India, Mathur Ashwani ,   Department of Biotechnology, Jaypee Institute of Information Technology Noida, A-10, Sector-62, Noida, 201309, Uttar Pradesh, India
Published: June 2024

The significance of expression systems for quickly creating enough numbers of therapeutic monoclonal antibodies to make them available to patients has been heightened in recent years due to advances in the creation of genetically modified monoclonal antibodies. The conventional method for making recombinant proteins involves first cloning the desired gene into an expression vector, and then testing how well it expresses itself in cells. For cellular expression and perpetuation, a plasmid containing the chosen genes is then cloned. The most significant and lucrative subset of biopharmaceuticals is monoclonal antibodies (mAbs). To temporarily produce an anti-CD20 monoclonal antibody in mammalian cells, this work created and assessed an antiCD20 mAb expression construct. The gene fragment was transferred to the expression vector after the vector (pcDNA3.1+) was synthesised by sequentially cloning the Light Chain (LC) and Heavy Chain (HC). We co-transfected HEK 293 cells and then examined the cell culture supernatant for antibody clone expression. Using this technology to transiently express the whole monoclonal antibody in mammalian cells was a breeze, and our findings prove it.
From Headaches to Obstructive Ileus: Following the Dots
Authors:   Radiology Department, Konstantopouleio Hospital, Athens, Greece, Triantopoulou C
Published: June 2024

Meningioma and colorectal cancer can co-exist in the same patient and may share mutations in common genetic loci and similar cellcycle regulating proteins in comparable mechanisms of action.
Prospects of Cyber Security in Smart Cities
Authors: Asimithaa K  , Aishwarya R I  , Tanish Milind Salunkhe  , Eunice J
Published: June 2024

As the world continues to embrace digital transformation the concept of smart cites has gained significant transaction. The phrase “smart city” is widely used to denote the use of information and communication technologies(ICT) to improve urban services and infrastructure. These cities leverage information and communication technologies, community-wide data and intelligent solution to optimize governance and improve the quality of life for citizens. Smart cities encompass a wide range of interconnected system and technologies that are designed to enhance various aspects of urban life. These can include smart grids, smart buildings, smart transportation systems and smart health care solutions. By integrating these technologies cities can improve efficiency and sustainability of the residents. Due to the valuable data that smart cities gather and process, as well as the vulnerabilities in their intricate systems, these cities are attractive targets for malicious cyber attackers. Cyber-attacks may also result in the capture and misuse of citizens' private information or video footage of their activities. For these reasons, it is imperative that cities prioritise cyber security measures to safeguard their citizens and infrastructure from potential cyber threats.
Issues of Urbanization and Economic Development in Nagaland: An Analysis of Dimapur Town
Authors: Imtikokla Ozukum  , Dr. Debojit Konwar
Published: June 2024

Urbanization is an important indicator of economic development. It brings development by fostering modernisation and industrialisation. However, it also generates various issues which are obstacles to the path of development. In Nagaland, Dimapur is the most urbanized town which contributes to the overall development of the state. But at the same time the urbanization process is accompanied by a host of socio-economic issues. Thus, this study is an attempt to highlight the important issues of urbanization and economic development in Dimapur town. The study is based on primary data conducted through a random sample survey of 200 persons in Dimapur. Krejcie-Morgan model has been used to calculate the population sample for the survey. Garret Ranking Analysis has been used in order to find out the most important issue from among the different issues of urbanization such as population increase, urban poverty, pollution, traffic congestion, unemployment, lack of proper infrastructure, violence and crime, environmental degradation, housing problem etc. The study found out that the problem of pollution is the most urgent issue of urbanization and economic development followed by the problem of unemployment. The least important issue is the increase in diseases or health hazards caused due to urbanization. A comprehensive approach by investing in infrastructure, education, environment, employment generation, provision of basic urban amenities, housing and sustainable urban growth is the need of the hour. Government, civil society, NGOs and private sector play a vital role in promoting inclusive and sustainable economic development.
Prediction of Liver Cirrhosis Using Classification Algorithms
Authors: Ms. Swedha  , Dr. P. Rajesh  , S. Muruganandham
Published: June 2024

The liver is known as the largest internal organ of the body and is well known for its unique property of regeneration. One of the most common diseases of the liver is liver cirrhosis. Liver cirrhosis is one of the most widespread chronic diseases. It is characterized by the gradual replacement of the liver tissue with the scarring tissue. Liver cirrhosis, being asymptomatic, makes it difficult to identify the disease and diagnose it. Due to this factor, there is no cure for liver cirrhosis, but rather to prevent the spread of cirrhosis and reverse its effects. The main objective of this case study is to employ machine learning techniques to predict the probability of being affected by this disease. Various machine learning algorithms are employed for classifying whether a patient will develop liver cirrhosis or not [5-7]. By using various classification algorithms, the highest accuracy was achieved through Logistic Regression, XG Boost, and KNN. The accuracy was 81% for all three cases. Logistic regression, with an execution time of 0.094 seconds, outperformed the other two models. This shows that logistic regression provides a significantly more accurate prediction of liver cirrhosis disease.
PRACTICES OF DEVELOPING THE SPACE OF THE MEMORIAL LANDSCAPE AS AN ELEMENT OF THE SYMBOLIC CAPITAL OF ARKAIM
Authors: Simakova Svetlana I.
Published: June 2024

At the present stage of Russian history, when there are large migration flows of people from the regions to the capital cities, it is important to increase the connection of people with their native land, to form historical, cultural and national memory. One means of this could be the creation of symbolic capital of the territory. Asignificant element of the symbolic capital of the Chelyabinsk region is the Chelyabinsk State Historical and Archaeological Museum-Reserve “Arkaim”. Thearticle presents the practices of developing the memorial landscape and their role in the formation of the symbolic capital of the archaeological complex. Arkaim is considered as an element of the symbolic capital of the Chelyabinsk region and a territory that itself has symbolic capital. The practices of exploration of the space of Arkaim by its visitors, which were identified from the notes of observers, are compared with the elements of symbolic capital identified by the author of the article in previous studies. The results of the comparison are characterized by discrepancies in the elements of the symbolic capital of the archaeological site, which are formed by the management of the reserve on the one hand and visitors to Arkaim on the other. The duality of the image of Arkaim and the elements of its symbolic capital is revealed.
POLEMICAL DISCOURSE ON RUSSIAN RADIO BROADCAST
Authors: Guskova Svetlana V.
Published: June 2024

The article specifies the features of modern Russian media discourse in the post-Soviet space. The emphasis is on clarifying the key characteristics of modern radio content, which in Russia differs significantly from the content of previous periods.The hypothesis of this study is the assumption that radio materials that are polemical in their content and form of presentation, published on the domestic airwaves, are of greater interest to the audience. Attention is focused on a relatively new phenomenon for Russian radio broadcasts – podcasting, which is popular among the Russian audience. Measurements of the most popular topics among podcast listeners are provided.The purpose of this study is to find out the features of polemical discourse on the air of modern domestic radio channels.The material for the study was the programs of popular domestic radio channels – “Vesti FM”, “Radio Mayak”, “Radio Russia”, the broadcasts of which are presented on the unified Internet platform of the VGTRK holding. The criteria for selecting radio channels and specific radio programs were the following: the popularity of the radio channel according to various measurements, its long history, the presence of analytical and original radio programs on the air of the radio channel. The research material consisted of radio broadcasts from the designated radio stations, the release of which was dated 2023. The selection of broadcasts was carried out using a continuous sampling method, while their polemical component was taken into account. The method of linguistic analysis made it possible to identify the speech features of polemical radio materials and clarify the popular linguistic means characteristic of modern radio polemics.During the research, a sociological method is used: the work presents the results of an annual survey, which is conducted in student audiences and allows us to identify the characteristics of media consumption among modern youth. Thus, in particular, the degree of popularity of radio as a mass media among youth audiences is clarified.
THE CIVIL WAR OF 1917–1922 IN RUSSIAN POPULAR SCIENCE PUBLICATIONS ON THE EXAMPLE OF THE MAGAZINE “RODINA” FOR 1989–1996
Authors: Kurenkov Viacheslav Ju.
Published: June 2024

In the article the content analysis of all publications of the magazine “Rodina” for 1989–1996 devoted to the Russian Civil War (1917–1922) is made. 37 articles are used to trace the changes in assessments of events and shifts of emphasis in the study of the topic. The magazine “Rodina” was chosen as the object of the study as one of the largest in Russia historical publications of popular science character. The chronological framework of the study is chosen according to the following criteria: The year 1989 is a turning point not only in the political life of the country, it also became such for historical science. On the pages of periodicals there appeared more and more criticism of the Soviet era as a whole, the events of 1917 were condemned. At the same time, some researchers put forward proposals to take a new look at the events of the first years of Soviet power, without denying their positive significance in general.The article evaluates all publications by year. Moreover, the peak of publications about the Civil War is in 1990. October 1993 is followed by a decline of almost two years. The year 1996 is chosen as the final point for two reasons. In connection with the presidential elections and the threat of communist revenge, the authors return after a long break (in 1994 and 1995) to the theme of the Civil War. Inaddition, in 1996 the first collection of scientific articles summarizing the first period of post-Soviet historiography of this topic was published in Russia. The general conclusion of the article is that the journal Rodina 1989–1996 is an example of an objective popular science publication, whose authors, sharing new knowledge with readers, do not offer a single concept, but invite to discussion and comprehension of their past.