bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudio de los beneficios y riesgos para la salud del consumo de café en adultos
Authors: Palencia-Sánchez Francisco
Published: May 2020

El café es una de las bebidas más populares en el mundo, según un informe delMinisterio de Agricultura y Desarrollo Rural de Colombia y de la Organización delas Naciones Unidas para la Agricultura y la Alimentación (2005) los cincoprimeros consumidores de café del mundo son: Estados Unidos, Brasil, Alemania,Japón e Italia. En Estados Unidos por ejemplo el 52% de la personas mayores de10 años han tomado café. (Barone y Roberts, 1996) La base de la popularidad delas bebidas que contienen cafeína radica en las propiedades que estimulan elestado de ánimo, disminuyen la fatiga y mejoran la capacidad intelectual(Tagliafico, 2008)
Efficacy of Ventilation Perfusion Lung Scanning and Computed Tomography Pulmonary Angiography for Chronic Thrombo-Embolic Pulmonary Hypertension
Authors: Currie Geoff , Currie Geoff , Wheat Janelle , Tong Michael
Published: May 2020

Introduction: The diagnostic approach for patients with suspected Chronic Thrombo-Embolic Pulmonary
Hypertension (CTEPH) is a combination of clinical and pre-test probability assessment, and diagnostic
imaging of computed tomography pulmonary angiogram (CTPA) or lung ventilation and perfusion
scintigraphy (V/Q). There is a paucity of literature, particularly for Southeast Asia (SEA) populations,
regarding the efficacy of these imaging approaches. This study investigated the sensitivity and specificity
of V/Q and CTPA in the diagnosis of CTEPH.
Methods: A retrospective analysis was undertaken on 133 consecutive patients presenting for pulmonary
hypertension (PH). The population included 42 males, 91 females, 683 V/Q images and 6288 CTPA images
for patients in the age range 18 to 93 years (mean 66). All data was retrospectively analysed by two nuclear
medicine physicians and classified as findings consistent with CTEPH or inconsistent with CTEPH. These
classifications were independently and collectively correlated with a final diagnosis of CTEPH or no
CTEPH.
Results: The accuracy, sensitivity, and specificity of V/Q for detection of CTEPH was 83.5%, 57.5% and
97.7% respectively, with a positive predictive value (PPV) of 93.1% and a negative predictive value (NPV)
of 80.8% when only high probability reports were considered CTEPH positive. The accuracy, sensitivity,
and specificity of V/Q for detection of CTEPH was 96.2%, 97.9% and 95.4% respectively, with a PPV of
92.0% and a NPV of 98.8% when both high probability and intermediate probability reports were considered
CTEPH positive. The accuracy, sensitivity and specificity of CTPA for detection of CTEPH were 70.7%,
19.2% and 98.8% respectively, with 90% PPV and 69.1% NPV. All 47 CTEPH studies were reported as
having abnormal lung perfusion.
Conclusion: This investigation has shown that V/Q is a more valuable diagnostic imaging tool in detecting
CTEPH than CTPA. In suspected CTEPH, a high/intermediate V/Q report is consistent with a positive
diagnosis. This is an important finding as CTEPH is a potentially treatable condition.
Development and validation of a risk scoring model for postoperative adult moyamoya disease
Authors: Kim Moinay , Park Wonhyoung , Chung Yeongu , Lee Si Un , Park Jung Cheol , Kwon Do Hoon , Ahn Jae Sung , Lee Seungjoo
Published: May 2020

OBJECTIVE

The current grading system for moyamoya disease (MMD) is focused on angiographic studies with limited clinical application. The authors aimed to determine relevant factors that may impact postoperative outcome and establish a scoring system to predict the functional outcome.

METHODS

Adult patients with MMD who underwent treatment between 1998 and 2016 were included. Factors such as age, sex, comorbidity, smoking, MMD family history, initial presentation, multimodal imaging modalities, and types of surgical revascularization were thoroughly reviewed. These factors were analyzed to determine possible risk factors related to unfavorable 6-month postoperative outcomes using the modified Rankin Scale (mRS) (unfavorable: mRS score ≥ 3). A scoring system was developed using these independent risk factors to predict the outcome and validated using prospectively collected data from multiple centers between 2017 and 2018.

RESULTS

Of 302 patients for whom applications were submitted, 260 patients (321 hemispheres) met the diagnostic criteria. In multivariate analysis, hyperlipidemia, smoking, cerebral infarction on preoperative CT or MRI, and moderately to severely reduced regional cerebrovascular reserve results from Diamox SPECT were significantly related to unfavorable outcome. The authors developed a scoring system and stratified patients into risk groups according to their scores: low-risk (score 0–3), intermediate-risk (score 4–6), and high-risk (score 7–9) groups. This model demonstrated both good discrimination and calibration using C-statistics and the Hosmer-Lemeshow goodness-of-fit test showing 0.812 (95% CI 0.743–0.881) (p = 0.568) for the development and 0.954 (95% CI 0.896–1) (p = 0.097) for the temporal and external validation cohort.

CONCLUSIONS

The authors’ scoring system is readily adoptable to predict the postoperative outcome for MMD. Their data revealed the importance of smoking and hyperlipidemia, which were the only modifiable factors included in the scoring system. The authors validated their scoring system both internally and externally and maintained good performance, highlighting the system’s generalizability and reliability.
Near-complete regression 19 years after Gamma Knife radiosurgery of vestibular schwannoma with massive pseudoprogression: case report
Authors: Li Lai-fung , Yu Chung-ping , Tsang Anderson Chun-on , Taw Benedict Beng-teck , Lui Wai-man
Published: May 2020

Gamma Knife radiosurgery (GKRS) is a frequent treatment choice for patients with small- to moderate-sized vestibular schwannoma (VS). However, pseudoprogression after GKRS is commonly observed, with a reported incidence ranging from 7% to 77%. The wide range of the reported incidence of pseudoprogression reflects the fact that there is no consensus on how it should be diagnosed.

The authors present the case of a 66-year-old woman who had a 2.5-cm right-sided VS treated with GKRS in 1997. The first posttreatment MRI obtained 5 months later showed that the tumor volume had increased to 9.7 cm3. The tumor volume increased further and reached its peak 24 months after treatment at 20.9 cm3, which was a 161% increase from pretreatment volume. Thereafter, the tumor shrank gradually and mass effect on the brainstem reduced over time. By 229 months after treatment, the tumor volume was 1.0 cm3, equaling 12.5% of pretreatment tumor volume, or 4.8% of peak tumor volume after treatment. This case demonstrates that if a patient remains asymptomatic despite a dramatic increase in tumor volume after GKRS, observation remains an option, because even a very sizable tumor can shrink with near-complete resolution. Patients undergoing GKRS for VS should be counseled regarding the possibility of pseudoprogression, and followed carefully over time while avoiding premature decisions for surgical removal after treatment.
Europejskie prawne podstawy ochrony informacji
Authors: Fleszer Dorota , Rogacka-Łukasik Anna
Published: May 2020

Zagadnienie informacji i zapewnienie jej prawnego bezpieczeństwa, zwłaszcza wobec przetwarzania jej w systemach informatycznych staje się istotną kwestią nie tylko dla prawodawcy krajowego. Biorąc pod uwagę istnienie transgranicznego przepływu informacji – co jest przecież niezbędne z punktu widzenia tworzenia wspólnego rynku – pojawiają się nowe zagrożenia, choćby te związane z koniecznością zapewnienia ochrony prywatności osób. Rozwiązania prawne na poziomie unijnym mają owe zagrożenia jeżeli nie wyeliminować, to choćby zminimalizować poprzez tworzenie wspólnych ram prawnych bezpieczeństwa informacji i ochrony danych osobowych. Celem niniejszej publikacji jest analiza europejskich regulacji prawnych stanowiących podstawę dla zapewnienia bezpiecznego przetwarzania informacji w systemach informatycznych.
Lista wierzytelności a umorzenie postępowania sądowego GLOSA do uchwały Sądu Najwyższego z dnia 18 stycznia 2019 r. (sygn. akt III CZP 55/18)
Authors: Wrzaszcz Paweł
Published: May 2020

W postępowaniu upadłościowym wierzyciel uzyskuje tytuł egzekucyjny w postaci wyciągu  z zatwierdzonej listy wierzytelności. Może on stanowić podstawę prowadzenia egzekucji, jednak dopiero po zakończeniu postępowania upadłościowego. Wierzyciel (powód) może jednak wcześniej zainicjować postępowanie sądowe, w toku którego może dojść do ogłoszenia upadłości dłużnika (pozwanego). Prowadzenie jednocześnie postępowania upadłościowego i postępowania sądowego, którego celem jest uzyskanie tożsamego tytułu egzekucyjnego, nie znajduje uzasadnienia faktycznego. Wydaje się, że koniecznym jest znalezienie takiego rozwiązania prawnego, które hamowałoby „dublowanie” prowadzenia dwóch postępowań, których efekt jest częściowo identyczny. Autor, bazując na treści głosowanego orzeczenia Sądu Najwyższego, wskazuje na istniejący problem prawny i na brak efektywnego rozwiązania prawnego. Wyjaśnia, dlaczego teza Sądu Najwyższego nie stanowi również remedium na problemy sądów i wystarczającej wskazówki, co do dalszych czynności procesowych w taki zaistniałym stanie faktycznym.
Kara śmierci a prawa człowieka
Authors: Migdał Marcin
Published: May 2020

W artykule starano się przedstawić perspektywę aksjologiczną kary śmierci, opierając się o standardy międzynarodowe, ze szczególnym uwzględnieniem ochrony praw człowieka, ochrony życia i zakazu tortur, oraz nieludzkiego, okrutnego lub poniżającego traktowania lub karania, poprzez przedstawienie systemów ochrony takich organizacji światowych jak: ONZ, Rada Europy, Unia Europejska oraz wewnątrzkrajowych zawartych przede wszystkim w Konstytucji RP.
Predictive Processing of
Interoception, Decision-Making, and Allostasis
Authors: Ohira Hideki
Published: May 2020

Emotional intelligence is composed of a set of emotional abilities, including recognition of emotional states in the self and others, the use of emotions to guide thoughts and behaviours, and emotion regulation. Previous studies have demonstrated that emotional intelligence is associated with mental health, social problem solving, interpersonal relationship quality, and academic and job performance. Although emotional intelligence has received much interest both in basic research fields and applied and clinical fields, the mechanisms underlying the functions of emotional intelligence remain unclear. The aim of the present article was to consider the mechanisms of emotional intelligence using a computational approach. Recent theories of emotion in psychology and neuroscience have emphasized the importance of predictive processing. It has been proposed that the brain createsinternal models that can provide predictions for sensation and motor movement, and perception and behaviors emerge from Bayesian computations rooted in these predictions. This theoretical framework has been expanded to include interoceptive perception of the internal body to explain affect and decision-making as phenomena based on interoception. This perspective has implications for understanding issues of emotional intelligence.
FAKTOR YANG BERHUBUNGAN DENGAN PEMILIHAN PENOLONG PERSALINAN DI KECAMATAN SUNGAI TABUK TAHUN 2017
Authors: Zakiah Zakiah , Yuniarti Yuniarti
Published: May 2020

Kematian ibu bersalin sangat erat kaitannya dengan penolong persalinan, sehingga salah satu upaya penurunan angka kematian ibu dapat dilakukan melalui upaya kesehatan ibu yaitu pertolongan persalinan oleh tenaga kesehatan. Namun masih ditemukan kelahiran yang ditolong oleh dukun bayi melalui cara tradisional. Tujuan penelitian ini adalah mengetahui faktor yang berhubungan dengan pemilihan penolong persalinan di Kecamatan Sungai Tabuk tahun 2017. Metode penelitian yang digunakan adalah survei analitik dengan rancangan cross sectional study. Populasi penelitian adalah semua ibu bersalin di Kecamatan Sungai Tabuk pada bulan Maret-Juli 2017. Sampel adalah ibu bersalin bulan Maret-Juli 2017 yang memenuhi kriteria inklusi dan eksklusi sejumlah 180 responden dengan proporsional simple randem sampling. Uji statistik yang digunakan adalah uji Chi Square. Hasil: diperoleh 152 (84,4%) responden yang memilih fasilitas kesehatan sebagai tempat persalinan, 157 responden (87,2%) umur tidak berisiko, 162 responden (90%) paritas rendah, 99 responden (55%) jarak dekat dengan fasilitas kesehatan, 112 responden (62,2%) dengan pendapatan keluarga yang rendah. Ada hubungan yang bermakna antara jarak dengan pemilihan penolong persalinan (p=0,000) dan tidak ada hubungan yang bermakna antara umur (p=0,212), paritas (p=0,100) dan pendapatan keluarga (p=0,378) dengan pemilihan penolong persalinan. Kesimpulan: faktor yang memiliki hubungan bermakna dengan pemilihan penolong persalinan adalah jarak ke fasiitas kesehatan.

 

Kata Kunci: pemilihan penolong persalinan, umur, paritas, jarak ke faslirtas kesehatan, pendapatan keluarga
LAND CAPABILITY EVALUATION FOR THE EFFECTIVE LAND USE AND SOIL PROTECTION MEASURES IN DOBRICH REGION
Authors: Stoinova Vihra , Nekova Diyana
Published: May 2020

An assessment of the suitability of the arable land in the Dobrich region for its effective agricultural use has been prepared using an eight rate classification where the land valuation strategy guarantees the conservation of natural resources, with particular attention to erosion as a limiting factor. Maps of the area with Land Capability evaluation classes for effective agricultural and erosion control land use and the actual risk of water erosion have been developed.This allows the use of an integrated approach to the definition of soil protection measures - taking into account both soil constraints (labeled with subclass land) and the need for prevention against erosion processes.
A set of different soil protection practices is recommended, each determined according to the specific soil, topographical and climatic features of the studied area, determined by the class and subclass of the land and depending on the degree of erosion risk and the way of land use (defined by Physical Blocks, 2016).
The agronomic assessments according to the soil and climate conditions of the main agricultural crops are lnked to the detailed large-scale database created in the GIS format and the most suitable places for their cultivation on the territory of the Dobrich region have been identified. The agronomic fitness of arable land for the cultivation of wheat, maize, peaches and vines is assessed. Maps for the degree of their agronomic fitness were prepared. It is clear that almost all of the entire territory has a very good and good land for cultivation of these crops.
Study of the State of Water Bodies Located within Kharkiv City (Ukraine)
Authors: Loboichenko Valentyna , Andronov Vladimir , Strelets Victor , Oliinykov Oleksii , Romaniak Mikhailo
Published: May 2020

The state of the water bodies located within the city has been analyzed in the paper. The factors influencing the physicochemical and microbiological composition of the urban surface water bodies have been considered. An experimental study of the state of the surface water bodies located within the large industrialized city of Kharkiv (Ukraine) has been carried out. The water of five reservoirs located within the city (Lake Komsomolskoe, Lake Ocheret, Pavlovskiy reservoir, Pond No. 1 in the gorge Hlybokiy Yar, Petrenkiv reservoir) and two reservoirs located outside the city (Lake Glubokoe No. 1 and Lake Glubokoe No. 2) have been analysed in terms of conductivity and mineralization. It has been found that for the urban water bodies, these parameters, in general, have higher values compared to the water bodies located in the recreational zone outside the city. The water of Petrenkiv reservoir and Lake Komsomolskoe is characterized by the highest values of conductivity and mineralization, while Lake Komsomolskoe and Pavlovskiy reservoir, due to the supply peculiarities, are most vulnerable to the influence of the external factors. The average values of conductivity for the studied reservoirs of Kharkiv are 590-910 μS/cm, for Lakes Glubokoe No. 1 and Glubokoe No. 2 they are equal to 500 μS/cm. The typical average mineralization values for the studied urban reservoirs are 400-670 mg/l, and for Lakes Glubokoe No. 1 and Glubokoe No. 2 are 345 mg/l. The error of values in all cases does not exceed 2%.
A Critical Review of Wind Energy Based Power Generation Systems
Authors: Gandhar Shashi , Ohri Jyoti , Singh Mukhtiar
Published: May 2020

Wind energy based power generation is globally popular as renewable source of energy and nowadays it is bridging the gap of increasing energy demand of world. It is termed as one of the best solution to the usage reduction of fossil fuels and in turned fighting with the problem of global warming.

The presented manuscript not only enumerates the significance of wind power but also highlights the important issues associated with wind energy based power plants: important ones are social and environmental. A case study is also presented in the paper modeled as wind energy generation system. Researchers and scientists are welcomed to provide the solutions to these highlighted issues so that these solutions can be used worldwide. This will make wind energy more popular and will be promoted exponentially.
Development of Reservoir Water Quality Index (WQI) Based on Long-term Physicochemical Parameters and Their Spatio-temporal Variations
Authors: Mamun Md , An Kwang-Guk
Published: May 2020

The main objectives of this study were to develop a Water Quality Index (WQI) model based on the physicochemical parameters in Daecheong reservoirs by using datasets of 1995-2016. The parameters included total phosphorus (TP), total nitrogen (TN), biological oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), chlorophyll (CHL), electrical conductivity (EC), dissolved oxygen (DO) and hydrogen ion concentrations (pH). The results had showed that physicochemical parameters varied spatially and temporarily as well as were correlated. TP was the most important key regulating factor for chlorophyll growth in the reservoirs. Seasonal summer TP influenced the autumn algal growth. The concentrations of total phosphorus (TP) was highest during the summer season (36±2 μgL-1) while it was lowest in the winter season (15±1 μgL-1). Summer monsoon directly influences the concentrations of total phosphorus in the reservoirs. Overall, the calculated WQI value suggested that site 1 (129.44) was in poor condition whereas sites 2 (116.06), 3 (103.51), 4 (89.3), 5 (82.007) and 6 (90.22) were in fair condition.
Heavy Metals in Sediments of the Vasyugan River Basin (Russian Federation), Chemical Composition and Environmental Risk
Authors: Efimov O. , Kondratenko L. , Barsukova M. , Philippova A.
Published: May 2020

The study aims to analyze the state of bottom sediments of the Vasyugan river. The river’s pollution because of oil production is considered. Samples have been taken during 2018. To determine the concentration of microelements, semi-quantitative spectral analysis, atomic absorption, and inversion voltammetric analysis methods have been used. The concentration of petroleum products has been determined by infrared spectrophotometry. Sediments of metals have been found in Vasyugan, mainly iron, aluminum, silver, magnesium, calcium and barium. On average, it is 0.5-2.0 times higher concentration compared to tributaries ( p ≤ 0.05). River basin Vasyugan is characterized by a moderate level of pollution resulting from oil production. The horizontal (surface water) and vertical migration of heavy metals and oil products (bottom sediments in rivers, peat in marshy areas) have been revealed. In total, 23 chemical elements are found, with a predominance in the Vasyugan riverbed and its tributaries.
A priori estimates for semistable solutions of p-Laplace equations with general nonlinearity
Authors: Aghajani A. , Mottaghi S.F.
Published: May 2020

In this paper we consider the p-Laplace equation [Formula: see text] in a smooth bounded domain [Formula: see text] with zero Dirichlet boundary condition, where [Formula: see text], [Formula: see text] and [Formula: see text] is a [Formula: see text] function with [Formula: see text], [Formula: see text] and [Formula: see text]. For the sequence [Formula: see text] of minimal semi-stable solutions, by applying the semi-stability inequality we find a class of functions E that asymptotically behave like a power of f at infinity and show that [Formula: see text] is uniformly bounded for [Formula: see text]. Then using elliptic regularity theory we provide some new [Formula: see text] estimates for the extremal solution [Formula: see text], under some suitable conditions on the nonlinearity f, where the obtained results require neither the convexity of f nor the strictly convexity of the domain. In particular, under some mild assumptions on f we show that [Formula: see text] for [Formula: see text], which is conjectured to be the optimal regularity dimension for [Formula: see text].
Paget disease of the breast: A national retrospective analysis of the US population
Authors: Sisti Andrea , Huayllani Maria T. , Restrepo David J. , Boczar Daniel , Advani Pooja , Lu Xiaona , Spaulding Aaron C. , Ball Colleen T. , McLaughlin Sarah A. , Forte Antonio J.
Published: May 2020

BACKGROUND: Paget’s disease of the breast is rare. The National Cancer Database (NCDB) is one of the largest tumor databases in the United States. METHODS: We queried the NCDB to identify male and female patients with Paget’s disease of the breast who were treated from January 1, 2004, through December 31, 2015. No age limitations were applied. Descriptive statistical analysis and survival analysis were performed. RESULTS: We analyzed the demographic, disease, and treatment characteristics of 7,191 patients with Paget’s disease of the breast. The median (range) age was 64 (20–90) years. Only 2.1% of patients were men, and 85.4% were white. The most common treatment was complete mastectomy (65.3%), followed by partial mastectomy (30.3%). Tumor destruction was performed in 0.1% of patients, and 4.3% of patients did not undergo any surgery. We examined survival in the subset of 6,864 patients who were treated surgically with complete mastectomy or partial mastectomy. The 5-year survival rate after surgery was 82.5% (95% CI, 81.1%–83.9%). Factors associated with shorter survival were older age, black race/ethnicity, higher tumor grade, regional lymph node metastasis, higher cancer stage, metastatic cancer, and larger tumor size. CONCLUSIONS: Paget’s disease of the breast usually affects patients older than 60 years, and the most common treatment is complete mastectomy. The 5-year overall survival rate of patients with Paget’s disease of the breast is greater than 80% but is lower among older and black people.
Multi-behaviors coordination controller design with enzymatic numerical P systems for robots
Authors: Wang Xueyuan , Zhang Gexiang , Gou Xiantai , Paul Prithwineel , Neri Ferrante , Rong Haina , Yang Qiang , Zhang Hua
Published: May 2020

Membrane computing models are parallel and distributed natural computing models. These models are often referred to as P systems. This paper proposes a novel multi-behaviors co-ordination controller model using enzymatic numerical P systems for autonomous mobile robots navigation in unknown environments. An environment classifier is constructed to identify different environment patterns in the maze-like environment and the multi-behavior co-ordination controller is constructed to coordinate the behaviors of the robots in different environments. Eleven sensory prototypes of local environments are presented to design the environment classifier, which needs to memorize only rough information, for solving the problems of poor obstacle clearance and sensor noise. A switching control strategy and multi-behaviors coordinator are developed without detailed environmental knowledge and heavy computation burden, for avoiding the local minimum traps or oscillation problems and adapt to the unknown environments. Also, a serial behaviors control law is constructed on the basis of Lyapunov stability theory aiming at the specialized environment, for realizing stable navigation and avoiding actuator saturation. Moreover, both environment classifier and multi-behavior coordination controller are amenable to the addition of new environment models or new behaviors due to the modularity of the hierarchical architecture of P systems. The simulation of wheeled mobile robots shows the effectiveness of this approach.
Digital information diversity and political engagement: The impact of website characteristics on browsing behavior and voting participation
Authors: Al-Hasan Abrar , Khalil Omar , Yim Dobin
Published: May 2020

Digital information is a new source of political information for citizens. News websites differ in the diversity of news content that they deliver, and such difference may have varied impacts on political behavior. This study explores the impact of news website characteristics on users’ news browsing behaviors, and in turn on voting participation. Using datasets on Internet browsing and U.S. presidential elections, the study finds indications that both the popularity and apparent bias of websites have an impact on the browsing behaviors of users. Non-biased websites have more user visits and longer user visits than biased websites, which positively correlate with users’ voting behaviors. Also, the longer users navigate news websites and the more users visit the news website, the higher the apparent political participation. The paper concludes with the implications of the research for political systems and news content providers.
Evolution of the Research Literature and the Scientific Community of Alzheimer’s Disease from 1983-2017: A 35-Year Survey
Authors: Robert Claude , Wilson Concepción S. , Lipton Richard B. , Arreto Charles-Daniel
Published: May 2020

This study surveys the development of Alzheimer’s disease (AD) in the research literature, the scientific community, and the journals containing AD papers over a 35-year period. Research papers on AD published from 1983 to 2017 in journals indexed in the Web of Science were analyzed in seven five-year periods. The number of AD papers increased from 1,095 in 1983–1987 to 50,532 by 2013–2017 and in the same time period, the number of participating countries went from 27 to 152. The US was the most prolific country throughout, followed by several European countries, Canada, Australia, and Japan. Asian countries have emerged and by 2013–2017, China surpassed all but the US in productivity. Countries in Latin America and Africa have also contributed to AD research. Additionally, several new non-governmental institutions (e.g., ADNI, ADI) have emerged and now play a key role in the fight against AD. Likewise the AD scientific publishing universe evolved in various aspects: an increase in number of journals containing AD papers (227 journals in 1983–1987 to 3,257 in 2013–2017); appearance of several AD-focused journals, e.g., Alzheimer’ s & Dementia, Journal of Alzheimer’ s Disease; and the development of special issues dedicated to AD. Our paper complements the numerous extant papers on theoretical and clinical aspects of AD and provides a description of the research landscape of the countries and journals contributing papers related to AD.
Evolving Frontline Treatment Landscape for Advanced or Metastatic Renal Cell Carcinoma
Authors: Jain Rohit K. , Lara Primo N.
Published: May 2020

The treatment landscape of metastatic renal cell carcinoma (mRCC) is evolving very rapidly. Until recently, targeted monotherapy with vascular endothelial growth factor (VEGF)-tyrosine kinase inhibitors (TKIs) such as sunitinib, pazopanib and cabozantinib were considered the predominant frontline treatment options. In 2018, combination immune checkpoint inhibitor (ICI) therapy with ipilimumab and nivolumab was approved by the United States’ Food and Drug Administration (FDA) for intermediate- and poor-risk patients. Subsequently, the FDA approved combination regimens consisting of a VEGF-TKI with an immune checkpoint inhibitor for all risk categories: pembrolizumab-axitinib and avelumb-axitinib. In the context of these new developments and several ongoing trials in treatment naïve clear-cell mRCC, there remains a dilemma among treating physicians about the choice of the most appropriate therapy as well as how to sequence these agents. In this review, we aim to highlight the available data on immunotherapy-based combinations and to provide a contemporary perspective on the optimal approach to patients with mRCC.
Dosimetric evaluation of PASSAG-U polymer gel dosimeter: Dependence of dose rate and photon energy
Authors: Farhood Bagher , Mohammadi ASL Kamal , Sarvizadeh Mostafa , Aliasgharzadeh Akbar
Published: May 2020

OBJECTIVE:

Several physical factors such as dose rate and photon energy may change response and sensitivity of polymer gel dosimeters. This study aims to evaluate the R2-dose response and sensitivity dependence of PASSAG-U gel dosimeters with 3% and 5% urea on dose rate and photon energy.

MATERIALS AND METHODS:

The PASSAG-U gel dosimeters were prepared under normal atmospheric conditions. The obtained gel dosimeters were irradiated to different dose rates (100, 200, and 300 cGy/min) and photon energies (6 and 15 MV). Finally, responses ( R2) of the PASSAG-U gel dosimeters with 3% and 5% urea were analyzed by MRI technique at 1, 10, 14 days after the irradiation process.

RESULTS:

The findings showed that the R2-dose responses of PASSAG-U gel dosimeters with 3% and 5% urea do not vary under the differently evaluated dose rates and photon energies. The R2-dose sensitivity of PASSAG-U polymer gel dosimeter with 3% urea does not change under the differently evaluated dose rates and photon energies, but it changes for PASSAG-U polymer gel dosimeter with 5% urea. The dose resolution values ranged from 0.20 to 0.86 Gy and from 0.27 to 2.20 Gy for the PASSAG-U gel dosimeter with 3% and 5% urea for the different dose rates and photon energies, respectively. Furthermore, it was revealed that the R2-dose response and sensitivity dependence of PASSAG-U gel dosimeters with 3% and 5% urea on dose rate and photon energy can vary over post irradiation time.

CONCLUSIONS:

The study results demonstrated that dosimetric characteristics (dependence of dose rate and photon energy, and dose resolution) of PASSAG-U gel dosimeter with 3% were better than those of PASSAG-U gel dosimeter with 5% urea.
Consecuencias políticas de la unión monetaria para la Unión Europea y para Europa
Authors: TIETMEYER H.
Published: May 2020

En unos momentos en que abundan las expectativas y los interrogantes sobre la unión monetaria, que ya es un hecho para once países de la Unión Europea, RFS agradece vivamente a su autor la oportunidad de publicar este texto. Por la autoridad de quien lo escribe y por la claridad de sus planteamientos creemos ofrecer a nuestros lectores un testimonio de indiscutible interés. En él se subrayan las condiciones inexcusables para el éxito del euro, pero se expresan también algunas reflexiones de sumo interés sobre el futuro político de la Unión Europea. Aunque el texto está escrito antes de la Cumbre Europea de mayo, su contenido no ha perdido ni un ápice de su actualidad.
La pequeña y mediana empresa: límites, alcance y posibilidades
Authors: Morales Gutiérrez Alfonso Carlos
Published: May 2020

La pequeña y mediana empresa (PYME) es objeto de numerosas referencias en el mundo socioeconómico. Desencantados del impacto real de la gran empresa existe cierta tendencia a redescubrir el valor de las pequeñas experiencias empresariales. En el presente trabajo se plantean tres objetivos relacionados con este agente empresarial: delimitar el alcance de sus condicionamientos íntrínsecos –originados por su tamaño–, clarificar las posibilidades efectivas respecto a las expectativas que despiertan en el mundo económico, y por último, proponer algunas estrategias de acción entresacadas de algunas experiencias empresariales con éxito. En este empeño se pondrán de manifiesto los inconvenientes y ventajas de la PYME respecto a las empresas de otra dimensión. En segundo lugar, se tendrán que deshacer una serie de mitos acerca de la pequeña y mediana empresa que se han ido propagando poco a poco. Este horizonte desmitificado nos conducirá a un perfil más cercano de lo que está ocurriendo en la realidad empresarial, y nos permitirá trazar a grandes rasgos unas líneas básicas en las coordenadas de una pequeña y mediana dimensiónpara un funcionamiento empresarial con éxito.
"Cambios en la construcción social de lo rural. De la autarquía a la globalización" (Recensión)
Authors: Gómez Mateos Jesús
Published: May 2020

Recensión de la obra: ENTRENA DURÁN, F. (1998), Cambios en la construcción social de lo rural. De la autarquía a la globalización, Tecnos, Madrid, 197 págs.
"La Izquierda y el Cristianismo" (Recensión)
Authors: Sequeiros San Román Leandro
Published: May 2020

Recensión de la obra: DÍAZ-SALAZAR, R. (1998), La Izquierda y el Cristianismo, Ediciones Taurus, colección «Pensamiento», Madrid, 436 págs.
"Compasión y cálculo. Un análisis crítico de la cooperación no gubernamental al desarrollo" (Recensión)
Authors: Ortega Carpio Mª Luz
Published: May 2020

Recensión de la obra de: SOGGE, D. (ed.) (1998), Compasión y cálculo. Un análisis crítico de la cooperación no gubernamental al desarrollo, Icaria, Barcelona, 286 págs.
Argelia, de la independencia a la crisis
Authors: Gay Armenteros Juan C.
Published: May 2020

Nos apunta el autor de este estudio que «las muertes, las matanzas, el horror y la desesperanza de las gentes de Argelia requiere de nosotros, al menos, una atención más objetiva, que no se limite al desprecio y la incomprensión», ya que si no «cuando queramos reaccionar podemos tener instalado el horror en nuestras ciudades, pueblos y campos, (...) no por invasión sarracena, sino porque el horror de la sinrazón es el mismo entre musulmanes, cristianos, budistas y hasta ateos». Este artículo pretende precisamente eso: darnos una visión más objetiva de lo que está aconteciendo en la Argelia actual, y para ello se realiza un breve análisis de la situación político–social de este país desde su independencia hasta el día de hoy.
La influencia del estilo directivo en el compromiso organizativo
Authors: Ariza Montes José Antonio
Published: May 2020

La dirección de personas en las organizaciones ha sufrido un proceso de evolución cuyo futuro parece encontrarse en la gestión de los activos intelectuales –el conocimiento– y emocionales –los valores–. Este último aspecto es el objeto fundamental del presente trabajo. El compromiso individual con la organización constituye, en opinión del autor, un elemento clave que condicionará la gestión de las empresas y organizaciones del próximo siglo. Conocer cuáles son las implicaciones que se derivan de la utilización de un cierto estilo de dirección permitirá, por tanto, diseñar una política eficaz en la gestión del compromiso.
La solidaridad interterritorial en cuestión
Authors: Redacción Consejo de
Published: May 2020

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Tres paradigmas del trabajo social
Authors: Yuste, S.I. Rafael
Published: May 2020

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"Causes of Growth and Stagnation in the World Economy" (Recensión)
Authors: Rodero Cosano Javier
Published: May 2020

Recensión de la obra de: KALDOR, N. (1996), Causes of Growth and Stagnation in the World Economy. Cambridge University Press, Cambridge. 230 págs.
Karakteristik Guru dalam Tradisi Pendidikan Nahdlatul Wathan, Lombok
Authors: Hadisaputra Prosmala , Bin Yussuf Ahmad , Binti Tengku Kasim Tengku Sarina Aini
Published: May 2020

This article discusses the characteristics of teacher who teaches Islamic sciences in the perspective of the Nahdlatul Wathan educational tradition, comprehensively. On the other hand, this article is one form of response to the moral degradation of teachers that have recently been rife, especially in Indonesia. This article is the result of qualitative research with a literature approach. Primary data are the books of Tuan Guru Kiai Haji Muhammad Zainuddin Abdul Madjid (Sheikh), which include Wasiat Renungan Masa (Book), Batu Ngompal (Book), the struggle song of Nahdlatul Wathan, and the recording of Sheikh's speech during his lifetime. Secondary data consists of scientific journals and relevant research results, as well as Islamic education books, Sufism, tafsīr and hadīth. Data was collected offline and online, then analyzed by using the NVivo 12 Plus software. This study shows that nine characteristics must be possessed by religious teachers who teach in the Nahdlatul Wathan madrasas/pesantrean (Islamic boarding school), namely: murshīd, sincere, obedient, mandate, behave as the teacher's morals, have a clear pedigree (silsilah/sanad), wise and polite in speaking, competent, and straight (istiqamah). This study concludes that the characteristics of the teacher mentioned in the will of the Sheikh are based on the results of contemplation (tafakkur), empirical experience (tajrībah), and extensive knowledge.
Use of Column for the adsorption of Ni(II) and Cu(II) from aqueous solution using Acasia arabica tree bark substrate
Authors: A. D. Gharde , B. D. Gharde
Published: May 2020

Salt of various heavy metals and other potentially dangerous are being discharged into the aquatic environment. Water containing vital concentration of some of heavy metal ions are harmful to human being, animal as well as aquatic organisms. The toxicity of some heavy metal ions, even at the trace level has been recognised with respect to the public health for many years. Metals such as Mercury, Lead, Cadmium, Copper and Chromium are under this category. Many metals have been evaluated as harmful to aquatic life above certain toxicity level. Any type of pollution brings about noticeable changes in the physiochemical parameters of the water, therby making it unsuitable for some beneficial uses. Thus, pollution causes changes in almost in the parameter. When increasing the pace of industrialisation along with population explosion, urbanisation and green revolution are reflected in varying degree of purity of water, soil and air. Majority of industries are water based and considerable volume of waste water is discharged to the environment either untreated or inadequately treated leading to the problem of surface and ground water pollution. The capital cost and operating waste water treatment system are rising on one hand and on the other there is a pressing demand for the treatment of waste water generated by increase residential and industrial development.
Peran Tingkat Penyelesaian Tindak Lanjut Rekomendasi Hasil Pemeriksaan Dalam Memoderasi Faktor Kelemahan Sistem Pengendalian Internal
Authors: Triono Triono , Subowo Subowo
Published: May 2020

This study aims to determine the role of the level of follow up TLRHP in moderating the factors that influence the weaknesses of the district / city local government’s internal control system in Central Java Province in 2014-2016. The population in this study are total of 35 districts / cities. This study uses secondary data obtained by documentation studies. The sampling technique used in this study is a saturated sample technique. This study uses descriptive statistical techniques, classic assumption tests, and moderation regression analysis with absolute difference value test models processed using IBM SPSS 23 applications. Government size, local income, capital expenditure, the level of completion of the follow-up of the audit results and moderation result together influence the weaknesses of the internal control system. The level of completion of the follow-up of the audit results has a significant negative effect on the weaknesses of the internal control system, the completion level of follow-up recommendations results in moderating the relationship of capital expenditure with the weaknesses of the internal control system
Pengaruh Pengungkapan Corporate Social Responsibility Terhadap Return Saham Dengan Return On Asset Sebagai Variabel Moderating
Authors: Ikrima Alia Sifa , Asrori Asrori
Published: May 2020

The purpose of this study was to analyze about the effect of economic, environmental, and social corporate social responsibility disclosure of stock returns with ROA as a moderating variable. The data analysis methods used were Moderation Regression Analysis (MRA). The results of the study showed that the economic CSRD and environmental CSRD had no effect on stock returns. While, CSRD and the social CSRD had a positive and significant effect on stock returns. In addition, ROA was able to moderate the positive effect of social CSRD on stock returns. However, ROA was not able to moderate the effect of CSRD, economic and environmental CSRD on stock returns. The conclusion from this study was the higher the disclosure of CSRD and social CSRD, the higher the stock returns will be. On the other hand, ROA strengthens the effect of social CSRD on stock returns.
Commodity qualities of rainbow trout grown on feed “Aller Aqua”
Authors: Bobel I. Y. , Pivtorak J. I.
Published: May 2020

Growing trout under closed water supply is linked to economic issues such as high planting density per unit area and the choice of granular feed, which in terms of value should be inexpensive and fully meet the needs of fish with all the necessary nutrients and nutrition. This approach is reflected in the materials of the scientific and practical publication on the intensity of growth and assessment of marketable qualities of trout for use in the feeding of granulated compound feeds of the firm “Aller Aqua”. Scientific research consisted in determination of morphometric indices of different age groups of trout, studies of chemical, amino acid and lipid composition of tissues, which allowed us to draw conclusions about the efficiency of feeding fish with the investigated feed. The research and production experiment was conducted in the conditions of PJSC “Bilshevtsi-Fish”, located in the village Bilshevtsi of Ivano-Frankivsk region. In order to study the effect of different types of compound feed on the exchange processes in rainbow trout, three-stage studies were conducted. The research is based on a comparative assessment of the impact of the above granular feed on the overall functional state of fish growth and quality indicators of the products obtained. The selection of appropriate feed for the rational supply of fish needs with all the necessary nutrients is of particular importance in the planned production of salmon fisheries, the demand for which is constantly growing in human nutrition. Therefore, the nutrients contained in the feed should not only support the vital activity of the organism, but also promote its growth and ensure the normal functioning of the whole organism. The feed used granular feed from the manufacturer Aller Aqua and Biomar, the recipe and the diameter of the granules according to the age and weight of the fish. Feed composition and nutrition were consistent with the period of fish cultivation. The daily rate of feed was calculated in accordance with conventional methods in fisheries, taking into account the temperature of the water and the weight of the fish. The purpose of the study was to study the effect of the tested feed on the functional state of growth, biochemical parameters of muscle tissue and liver. Only healthy fish without visible damage, which were caught immediately prior to the study, were used for the study and were not fed for 24 h. During the research, the main linear indicators were determined using conventional techniques in fisheries. The conducted studies allow us to conclude on the direct link between the marketable qualities of rainbow trout and the feed consumed, their quality composition and nutritional value. In addition, the influence of abiotic factors, which were the same for all trout groups studied, were considered, which are equally important and, along with rational feeding, occupy a key place in production.
Management of acid sulfate soils under aerobic and anaerobic soil conditions revolves around organic matter and live plant macrophytes
Authors: Michael Patrick
Published: May 2020

In acid sulfate soils (ASS), it is well established that sulfuric soil acidity is managed by application of a neutralising agent and sulfidic soil oxidation is prevented by water table management. This review summarizes recent studies using organic matter in amelioration of sulfuric soil acidity and curtailing of sulfidic soil oxidation by discussing the changes induced on soil pH, Eh and sulfatecontents under varying soil moisture regimes. Increase in low pH, low Eh values and reduction in sulfate content have been observed in sulfuric and sulfidic soil following organic matter amendment under aerobic and anaerobic soil conditions. When organic matter co-existed with live plants, pH decreased with correspondingly high Eh values and high sulfate contents in almost all cases, even under anaerobic soil conditions. Practical consideration shows that application of organic matter by incorporation and spot application as surface mulch followed by establishment of plants under general soil use and management conditions create microniches conducive for root growth and negate the mechanisms that lead to severe acidification associated with live plants.
Adlay (Coix Iacryma-jobi L.) and Napier grass (Pennisetum purpureum Schum.) intercropping and fertilization schemes as climate smart strategy for food and feed production
Authors: Gorne Nello , Aradilla Agripina
Published: May 2020

Adlay is considered an alternate staple food crop in the Philippines while napier is a versatile multipurpose fodder crop. Effective intercropping and fertilization strategies for the production of these crops could help address the problems on food and feed supply. The objectives ofthe study were to 1) evaluatethe growth and yield of adlay with napier at various fertilization scheme; 2) determine the appropriate intercropping and fertilization schemes for maximum adlay production; 3) appraise the efficiency of intercropping scheme; and 4) assess the profitability of intercropping adlay with napier at various fertilization scheme. The study was laid out in split-plot with three intercropping scheme (C1=Monocrop adlay, C2=Adlay with napier at 1:1 row ratio, and C3=Adlay with napier at 2:1 row ratio) and five fertilization schemes (F0=Unfertilized, F1=120kg ha-1 N inorganic fertilizer, F2=60kg ha-1 N inorganic fertilizer+ 1t ha-1 chicken dung, F3=30kg ha-1 N inorganic fertilizer+ 1 .5t ha-1 chicken dung, and F4=2t ha-1 chicken dung). Fertilization scheme significantly affected the days to flowering and maturity, vegetative tillers, plant height, number of productive and unproductive tillers, panicle length, herbage and grain yields of adlay and also the tiller and herbage yield of napier as well as the land equivalent and area time equivalent ratios. Fertilization with pure inorganic fertilizer or with combinations ofchicken dung had ROI of 1.31 to 1.44 per peso invested.
Visualization 3D Mosaik Picture Formation
Authors: Firdaus Noor
Published: May 2020

This study aims to reveal and explore the visualization of the formation of Mosaic 3D Formation of 2,957 new students at UPN Veteran Jakarta. Visualization through the concept of Aerial Cinematography is expected to be an aesthetic enhancer in mosaic works. This mosaic is a work of art made of elements and arranged so that it becomes a 3-dimensional image or design. This research was designed as an experimental study which focused on two parts. First, try out the composition of the picture elements to form a unity that is in harmony with the overall formation movement. The second trial focused on visual exploration, which originated from the concept of aerial cinematography. The resulting mosaic visualization consists of three images with the writing of Patribera 2019, Kampus Bela Negara and PIKIR work culture logo with super high angles and long distances or called birds point of view.