bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship between Allostasis and Mental Health Patterns in a Pre-Deployment French Military Cohort
Authors: Trousselard Marion , Claverie Damien , Fromage Dominique , Becker Christel , Houël Jean-Guillaume , Benoliel Jean-Jacques , Canini Frédéric
Published: October 2021

(1) Background: While a number of studies among military personnel focus on specific pathologies such as post-traumatic stress disorder (PTSD), anxiety, and depression, they do not address the cumulative impact on mental health of stressors related to the profession. The present study aims to determine the relationship between allostatic load and mental health status in a cohort of fit-for-duty soldiers prior to their deployment to Afghanistan. The aim is to better-define the consequences of stressor adjustment. (2) Methods: A cohort of 290 soldiers was evaluated in a cross-sectional study with respect to psychopathology (PTSD, anxiety, depression), psychological functioning (stress reactivity, psychological suffering), and allostatic profile (urinary cortisol and 8-iso-PGF2α, blood cortisol and BDNF). A hierarchical cluster analysis was used to identify allostatic patterns. (3) Results: Around 10% of the cohort reported high scores for psychopathology, and biological alterations were identified. For the remainder, four allostatic profiles could be identified by their psychological functioning. (4) Conclusions: Both biological and psychological assessments are needed to characterize subthreshold symptomatology among military personnel. The psychological significance of allostatic load should be considered as a way to improve health outcomes.
Copeptin and Stress
Authors: Martino Marianna , Arnaldi Giorgio
Published: October 2021

Vasopressin (AVP) and copeptin are released in equimolar amounts from the same precursor. Due to its molecular stability and countless advantages as compared with AVP, copeptin perfectly mirrors AVP presence and has progressively emerged as a reliable marker of vasopressinergic activation in response to osmotic and hemodynamic stimuli in clinical practice. Moreover, evidence highlighting the prognostic potential of copeptin in several acute diseases, where the activation of the AVP system is primarily linked to stress, as well as in psychologically stressful conditions, has progressively emerged. Furthermore, organic stressors induce a rise in copeptin levels which, although non-specific, is unrelated to plasma osmolality but proportional to their magnitude: suggesting disease severity, copeptin proved to be a reliable prognostic biomarker in acute conditions, such as sepsis, early post-surgical period, cardiovascular, cerebrovascular or pulmonary diseases, and even in critical settings. Evidence on this topic will be briefly discussed in this article.
Taxonomy and Phylogeny of the Favolaschia calocera Complex (Mycenaceae) with Descriptions of Four New Species
Authors: Zhang Qiu-Yue , Dai Yu-Cheng
Published: October 2021

Favolaschia calocera was originally described from Madagascar, and reported to have a worldwide distribution. In the current study, samples of the Favolaschia calocera from Central America, Australia, China, Kenya, Italy, New Zealand, and Thailand were analyzed by using both morphological and molecular methods. Phylogenetic analyses were based on the internal transcribed spacer (ITS) dataset, and the combined five-locus dataset of ITS, large subunit nuclear ribosomal RNA gene (nLSU), the small subunit mitochondrial rRNA gene (mt-SSU), the small subunit of nuclear ribosomal RNA gene (nu-SSU), and the translation elongation factor 1α (TEF1). Our study proves that Favolaschia calocera is a species complex, and six species are recognized in the complex including four new species. Three new species F. brevibasidiata, F. brevistipitata, and F. longistipitata from China; and one new species F. minutissima from Asia. In addition, Favolaschia claudopus (Singer) Q.Y. Zhang & C. Dai, earlier treated as a variety of Favolaschia calocera R. Heim, were raised to species rank. Illustrated descriptions of these five new taxa are given. An identification key and a comparison of the characteristics of species in the Favolaschia calocera complex are provided.
Influence of Soil Properties on P Pools and Its Effect on Forest Productivity in Mediterranean Calcareous Soils
Authors: Martín-Sanz Ruth C. , Pando Valentín , Bueis Teresa , Turrión María-Belén
Published: October 2021

Although soil phosphorus is essential for vegetation growth it is not always found in labile forms, hampering its absorption by plants, and is limited in forest ecosystems. This study explores soil P state and availability in calcareous soils, determining which processes affect its different pools and which soil parameters influence forest productivity of a Mediterranean pine species. We used a sequential fractionation method to determine P fractions in the soil according to their lability and their organic or inorganic nature. Those fractions were related to different soil and climatic parameters and to the site index in 32 Pinus halepensis plots of the National Spanish Forest Inventory. Soil texture, carbonates content, water retention capacity and organic matter substantially affected P fractions in the calcareous soils studied. Membrane extractable P was mainly influenced by organic matter-related parameters while the predominant P fraction in these soils, the primary P, was linked to the carbonates content. The biological mineralization processes played a key role in the soil P cycle. Total P, carbonates content, soil texture and water availability drove forest productivity in the studied plots.
Thermally Modified Wood Exposed to Different Weathering Conditions: A Review
Authors: Godinho Delfina , Araújo Solange de Oliveira , Quilhó Teresa , Diamantino Teresa , Gominho Jorge
Published: October 2021

Outdoor wood applications are exposed to several different biotic and abiotic factors, and for that reason, they require protection to increase their service life. Several technologies of wood protection are already commercialized. One of these technologies is thermal modification, which refers to the structural, mechanical, and chemical transformations occurring in the lignocellulosic material when gradually heated up to specific temperature ranges. In the past few years, several researchers have undertaken weathering resistance evaluations on different wood species. Some cases have considered natural exposure in different countries with different climatic conditions, while others focused on artificial exposure under UV and xenon radiation tests. Most works evaluated the weathering effects on the chemical, mechanical and physical, and anatomical shifts compared to the original characteristics of the material. This review has established a considerable lack of studies in the bibliography focusing on abiotic factors, such as the industrial and maritime environment, or even isolated climatic factors such as salt spray (simulating maritime environments) or pollutant gases (simulating industrial environments). This lack of information can be an opportunity for future work. It could help to understand if thermally modified wood is or is not sensitive to pollutant gases or salinity, or to a combination of both. By knowing the degradation mechanisms caused by these factors, it will be possible to study other forms of protection.
Genetic Structure and Geographical Differentiation of Larix sibirica Ledeb. in the Urals
Authors: Chertov Nikita , Vasilyeva Yulia , Zhulanov Andrei , Nechaeva Yulia , Boronnikova Svetlana , Kalendar Ruslan
Published: October 2021

The Ural Mountains and the West Eurasian Taiga forests are one of the most important centers of genetic diversity for Larix sibirica Ledeb. Forest fragmentation negatively impacts forest ecosystems, especially due to the impact of their intensive use on the effects of climate change. For the preservation and rational use of forest genetic resources, it is necessary to carefully investigate the genetic diversity of the main forest-forming plant species. The Larix genus species are among the most widespread woody plants in the world. The Siberian larch (Larix sibirica, Pinaceae) is found in the forest, forest-tundra, tundra (Southern part), and forest-steppe zones of the North, Northeast, and partly East of the European part of Russia and in Western and Eastern Siberia; in the Urals, the Siberian larch is distributed fragmentarily. In this study, eight pairs of simple sequence repeat (SSR) primers were used to analyse the genetic diversity and population structure of 15 Siberian larch populations in the Urals. Natural populations in the Urals exhibit indicators of genetic diversity comparable to those of Siberia populations (expected heterozygosity, He = 0.623; expected number of alleles, Ne = 4017; observed heterozygosity, Ho = 0.461). Genetic structure analysis revealed that the examined populations are relatively highly differentiated (Fst = 0.089). Using various algorithms for determining the spatial genetic structure, the examined populations formed three groups according to geographical location. The data obtained are required for the development of species conservation and restoration programs, which are especially important in the Middle Urals, which is the region with strong forest fragmentation.
Net Energy Analysis and Techno-Economic Assessment of Co-Production of Bioethanol and Biogas from Cellulosic Biomass
Authors: Jarunglumlert Teeraya , Prommuak Chattip
Published: October 2021

Co-production is a process based on the biorefinery concept that maximizes the benefit of biomass by reusing residue from the production of one product to produce others. In this regard, biogas is one of the most researched second products for the production of ethanol from cellulosic biomass. However, operating this scheme requires additional investment in biogas processing equipment. This review compiles data from research studies on the co-production of bioethanol and biogas from lignocellulosic biomass to determine which is more worthwhile: leaving the residue or investing more to benefit from the second product. According to previous research, ethanol stillage can be converted to biogas via anaerobic digestion, increasing energy output by 2–3 fold. Techno-economic studies demonstrated that the co-production process reduces the minimum ethanol selling price to a level close to the market price of ethanol, implying the possibility of industrializing cellulosic ethanol production through this scheme.
Underwater Target Recognition Based on Multi-Decision LOFAR Spectrum Enhancement: A Deep-Learning Approach
Authors: Chen Jie , Han Bing , Ma Xufeng , Zhang Jian
Published: October 2021

Underwater target recognition is an important supporting technology for the development of marine resources, which is mainly limited by the purity of feature extraction and the universality of recognition schemes. The low-frequency analysis and recording (LOFAR) spectrum is one of the key features of the underwater target, which can be used for feature extraction. However, the complex underwater environment noise and the extremely low signal-to-noise ratio of the target signal lead to breakpoints in the LOFAR spectrum, which seriously hinders the underwater target recognition. To overcome this issue and to further improve the recognition performance, we adopted a deep-learning approach for underwater target recognition, and a novel LOFAR spectrum enhancement (LSE)-based underwater target-recognition scheme was proposed, which consists of preprocessing, offline training, and online testing. In preprocessing, we specifically design a LOFAR spectrum enhancement based on multi-step decision algorithm to recover the breakpoints in LOFAR spectrum. In offline training, the enhanced LOFAR spectrum is adopted as the input of convolutional neural network (CNN) and a LOFAR-based CNN (LOFAR-CNN) for online recognition is developed. Taking advantage of the powerful capability of CNN in feature extraction, the recognition accuracy can be further improved by the proposed LOFAR-CNN. Finally, extensive simulation results demonstrate that the LOFAR-CNN network can achieve a recognition accuracy of 95.22%, which outperforms the state-of-the-art methods.
Relationship between Acceptance of Insects as an Alternative to Meat and Willingness to Consume Insect-Based Food—A Study on a Representative Sample of the Polish Population
Authors: Modlinska Klaudia , Adamczyk Dominika , Maison Dominika , Goncikowska Katarzyna , Pisula Wojciech
Published: October 2021

Despite their nutritional and ecological potential, insect-based food is rarely accepted by consumers. There may be a discrepancy between the consumers’ understanding of the need to reduce meat consumption and their personal food preferences. Our goal was to investigate the relationship between the acceptance of insects as a meat substitute, the willingness to buy and consume insect-based food, and the underlying factors. The study was conducted on a representative sample of the Polish population, and as in previous studies, our results showed that men who are more familiar with entomophagy pay more attention to the environmental impact of their food choices, are convenience-orientated and are more willing to accept insects as a meat substitute. However, people with higher levels of food neophobia and disgust sensitivity and lower levels of variety-seeking tendency are less willing to consume insects. Our study showed that the acceptance of insects as an alternative to meat (general perspective) does not translate into a willingness to buy and eat them (individual perspective). Consumers who declare their acceptance of insects as a meat substitute might not be willing to purchase insects for their consumption.
Red-Fleshed Apple Anthocyanin Extract Reduces Furan Content in Ground Coffee, Maillard Model System, and Not-from-Concentrate Apple Juice
Authors: Wang Bin , Jiang Shenghui , Wang Yanbo , Xu Jihua , Xu Meng , Sun Xiaohong , Zhu Jun , Zhang Yugang
Published: October 2021

Furan is a volatile and carcinogenic heterocyclic chemical compound that occurs in a wide range of thermally processed food. It can be induced during food-preparing processes by high temperatures and UV-C light. In the present study, the degradation of furan content in ground coffee, Maillard model system, and not-from-concentrate (NFC) apple juice by red-fleshed apple anthocyanin extract (RAAE) was studied. The results demonstrated that RAAEs had different degrees of degradation of furan content in coffee powder, and the RAAE from ‘XJ3’ had the most significant effect, with a reduction rate of up to 20%. Moreover, by adding RAAE to the Maillard model system, we found the amounts of furan were significantly reduced. At the same time, RAAE from ‘XJ3’ could observably reduce the content of furan in pasteurized NFC juice, with ‘Fuli’ NFC juice furan content decreasing the most, which was 68%. Taken together, our study demonstrated that the use of RAAE could be a feasible way to reduce furan content in ground coffee, Maillard model system, and NFC apple juice.
A Comprehensive Evaluation of Flavor Instability of Beer (Part 1): Influence of Release of Bound State Aldehydes
Authors: Lehnhardt Florian , Nobis Arndt , Skornia Andreas , Becker Thomas , Gastl Martina
Published: October 2021

Flavor instability of pale lager beer depends decisively on aroma-active aldehydes from the Maillard reaction, Strecker degradation, and lipid oxidation, which are formed in various oxidative and non-oxidative reactions. Therein, aldehydes can be formed de novo and be released from bound states to a free, aroma-active form during aging. During malting and brewing, proteolysis affects the amount of soluble nitrogen and thus flavor instability in different ways (e.g., precursors for de novo formation and binding agents for bound states). To isolate nitrogen-related aging processes, beers from malts (two barley varieties, three proteolytic malt modifications) were produced on a 50 L scale in part 1 of this study. Sensory analysis revealed increased flavor instability for beers with higher amounts of soluble nitrogen. Especially Strecker aldehydes significantly increased with malt modification. The release of bound state aldehydes revealed most free aldehydes in fresh beers and with higher malt modification. During aging, the equilibrium between free and bound state aldehydes shifted toward the free form. These results reveal a nitrogen-dependent bound pool of aldehydes that is depleted during aging and is responsible for aged aroma, especially in the early and medium stages of aging. Therefore, bound state aldehydes are indicators of the early-stage prediction of flavor instability already in a fresh condition.
Maintenance of Postharvest Quality and Reactive Oxygen Species Homeostasis of Pitaya Fruit by Essential Oil p-Anisaldehyde Treatment
Authors: Xu Yanmei , Cai Zhijun , Ba Liangjie , Qin Yonghua , Su Xinguo , Luo Donglan , Shan Wei , Kuang Jianfei , Lu Wangjin , Li Liling , Chen Jianye , Zhao Yating
Published: October 2021

The performance of p-Anisaldehyde (PAA) for preserving pitaya fruit quality and the underpinning regulatory mechanism were investigated in this study. Results showed that PAA treatment significantly reduced fruit decay, weight loss and loss of firmness, and maintained higher content of total soluble solids, betacyanins, betaxanthins, total phenolics and flavonoids in postharvest pitaya fruits. Compared with control, the increase in hydrogen peroxide (H2O2) content and superoxide anion (O2•−) production was inhibited in fruit treated with PAA. Meanwhile, PAA significantly improved the activity of antioxidant enzymes superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT). Moreover, PAA-treated pitaya fruit maintained higher ascorbic acid (AsA) and reduced-glutathione (GSH) content but lower dehydroascorbate (DHA) and oxidized glutathione (GSSG) content, thus sustaining higher ratio of AsA/DHA and GSH/GSSG. In addition, activities of ascorbate peroxidase (APX), glutathione reductase (GR), monodehydroascorbate reductase (MDHAR) and dehydrogenation ascorbic acid reductase (DHAR), as well as the expression of HpSOD, HpPOD, HpCAT, HpAPX, HpGR, HpDHAR and HpMDHAR, were enhanced after PAA treatment. The findings suggest that postharvest application of PAA may be a reliable method to control postharvest decay and preserve quality of harvested pitaya fruit by enhancing the antioxidant potential of the AsA-GSH cycle and activating an antioxidant defense system to alleviate reactive oxygen species (ROS) accumulation.
Commercial Bio-Packaging to Preserve the Quality and Extend the Shelf-Life of Vegetables: The Case-Study of Pumpkin Samples Studied by a Multimethodological Approach
Authors: Di Matteo Giacomo , Di Matteo Paola , Sambucci Matteo , Tirillò Jacopo , Giusti Anna Maria , Vinci Giuliana , Gobbi Laura , Prencipe Sabrina Antonia , Salvo Andrea , Ingallina Cinzia , Spano Mattia , Sobolev Anatoly P. , Proietti Noemi , Di Tullio Valeria , Russo Paola , Mannina Luisa , Valente Marco
Published: October 2021

A multidisciplinary protocol is proposed to monitor the preservation of fresh pumpkin samples (FP) using three commercial polymeric films: A made of biodegradable cellophane from regenerated cellulose pulp; B from corn starch, cassava and eucalyptus, C made of polylactic acid from corn starch, and a polyethylene film used as reference (REF). Chemical, mechanical and microbiological analyses were applied on packaging and fresh and packaged samples at different times. After an 11-day period, NMR spectroscopy results showed a sucrose increase and a malic acid decrease in all the biofilms with respect to FP; fructose, glucose, galactose levels remained quite constant in biofilms B and C; the most abundant amino acids remained quite constant in biofilm A and decreased significantly in biofilm B. From microbiological analyses total microbial count was below the threshold value up to 7 days for samples in all the films, and 11 days for biofilm C. The lactic acid bacteria, and yeasts and molds counts were below the acceptability limit during the 11 days for all packages. In the case of biofilm C, the most promising packaging for microbiological point of view, aroma analysis was also carried out. In this paper, you can find all the analysis performed and all the values found.
Assessment of Arabian Gulf Seaweeds from Kuwait as Sources of Nutritionally Important Polyunsaturated Fatty Acids (PUFAs)
Authors: Al-Adilah Hanan , Al-Sharrah Tahani Khalaf , Al-Bader Dhia , Ebel Rainer , Küpper Frithjof Christian , Kumari Puja
Published: October 2021

The fatty acid (FA) compositions of ten seaweeds representative of Chlorophyta, Rhodophyta, and Ochrophyta from Kuwait in the Arabian Gulf region were determined and are discussed in the context of their potential nutritional perspectives for seaweed valorization. All the seaweeds had higher saturated fatty acid (SFA) and lower monounsaturated (MUFA) and polyunsaturated fatty acid (PUFA) contents than those typical of tropical environments. Palmitic, myristic, stearic, oleic, linoleic, α-linolenic, and stearidonic acids were the major FAs detected. Arachidonic, eicosapentaenoic, and docosahexaenoic acids were detected in minor amounts. Conserved fatty acid patterns revealed phylogenetic relationships among phyla, classes, and orders matching the molecular phylogenies at higher taxonomic ranks. Hierarchical clustering analyses clearly segregated different seaweeds (except Codium papillatum and Iyengaria stellata) into distinct groups based on their FA signatures. All but one species (Chondria sp.) had health-beneficial n6/n3 PUFAs (0.33:1–2.94:1) and atherogenic (0.80–2.52) and thrombogenic indices (0.61–5.17). However, low PUFA/SFA contents in most of the species (except Ulva spp.) may limit their utilization in the formulation of PUFA-rich functional foods. Ulva spp. had substantially high PUFAs with PUFA/SFA > 0.4, n6/n3 (0.33–0.66) and atherogenic (0.80–1.15) and thrombogenic indices (0.49–0.72), providing substantial potential for their utilization in food and feed applications.
Tejuino, a Traditional Fermented Beverage: Composition, Safety Quality, and Microbial Identification
Authors: Rubio-Castillo Ángel Eduardo , Méndez-Romero José I. , Reyes-Díaz Ricardo , Santiago-López Lourdes , Vallejo-Cordoba Belinda , Hernández-Mendoza Adrián , Sáyago-Ayerdi Sonia G. , González-Córdova Aarón F.
Published: October 2021

This study aims to analyze the chemical and microbial composition and characterize volatile compounds from the artisanal and commercial Tejuino beverage. For this, eight samples are analyzed (four artisanal and four commercial). The chemical and microbiological quality is determined by standard methods, and volatile compounds are determined by solid-phase microextraction. Overall, the physicochemical composition and microbiological quality are higher for artisanal Tejuino (p < 0.05). The pH values were 3.20 and 3.62, and 0.76 and 0.46 meq of lactic acid for artisanal and commercial Tejuino, respectively. With volatile compounds analyzed, esters, benzenes, and aldehydes were predominant; meanwhile, ethanol was a volatile compound with the highest concentration for all samples. Saccharomyces cerevisiae and Limosilactobacillus fermentum were identified in artisanal Tejuino; yeasts of the Pichia genera and Lactiplantibacillus plantarum, for commercial Tejuino, and Enterococcus genus were identified in both samples. The characterization of both types of Tejuino allows us to update the information available on this important Mexican beverage. In addition, the isolation of lactic acid bacteria, as representative bacteria of both drinks, offers an area of opportunity to know the potential functionality of these bacteria in traditional fermented products.
Advances in Regression Kriging-Based Methods for Estimating Statewide Winter Weather Collisions: An Empirical Investigation
Authors: Wong Andy H. , Kwon Tae J.
Published: October 2021

Winter conditions create hazardous roads that municipalities work hard to maintain to ensure the safety of the travelling public. Targeting their efforts with effective network screening will help transportation managers address these problems. In our recent efforts, regression kriging was found to be a viable and effective network screening methodology. However, the study was constrained by its limited spatial extent making the reported results less conclusive and transferrable. In addition, our previous work implemented what has long been adopted in most of conventional studies—the Euclidean distance; however, use of the road network distance would, intuitively, result in further improving kriging estimates, especially when dealing with transportation problems. Therefore, this study improves upon our previous efforts by developing a more advanced kriging model; namely, network regression kriging using the entire state of Iowa with the significantly expanded road network. The transferability of the developed models is also explored to investigate its generalization potential. The findings based on various statistical measures suggest that the enhanced kriging model vastly improved the estimation performance at the cost of greater computational complexity and run times. The study also suggests that regional semivariograms better represent the true nature of the local variances, though an overall model may still function adequately if higher fidelity is not required.
Reading the Entrails: The Extractive Work of a Fence
Authors: Pyke Sue Hall
Published: October 2021

This essay offers an evisceration of my troubled links to ‘cattle country’, seeking a truth-telling that responds to my mother’s romancing. I trace my family’s part in the cattle industry imposed upon Jiman Country and Wulli Wulli Country, drawing on stories populated with the hooves of cattle, the flight of emus, and the stare of a goanna. I find myself in uncomfortable territory, complicit in the actions of my settler relatives in this region of Central Queensland, but to not examine this informal archive of possession feels like a lie. The stories that shape me begin with the tales of Mum’s foster-mother, my great-aunt, about the dreadful murderous harms done during the early settler occupation of Jiman Country. My family’s later deployment of this stolen land is a related act of war. I see a related mode of violence in tales of terrified cattle in nearby Wulli Wulli Country, Mum’s girl-self perched on the back of a weary horse, whip in her hand. In all this, there is me, telling tales, like settler writers before me, caught in the writing act, exposed as a fence, dealing in stolen goods, part of the ongoing posts of making up and wires of making do. Nonetheless, I take up my extractive blade, sharpened by a field trip to this region, and carve into my family history, with its legacy of generational violence to humans, cows, waterways, and earth, exposing three extractions: the near-genocidal murders of the Jiman and Wulli Wulli people; the ongoing slaughter of cattle; and finally, there, on the kill floor, entrails exposed, the stories of my mother, laid bare for this critical reading.
Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review
Authors: Hernández-Díaz Yazmín , Genis-Mendoza Alma Delia , González-Castro Thelma Beatriz , Tovilla-Zárate Carlos Alfonso , Juárez-Rojop Isela Esther , López-Narváez María Lilia , Nicolini Humberto
Published: October 2021

Background: Suicide behavior (SB) has been highly associated with the response to stress and the hypothalamic–pituitary–adrenal (HPA) axis. The aim of this study was to summarize the results obtained in genetic studies that analyzed the HPA axis—stress pathway and SB through a systematic review. Methods: We performed an online search in PubMed, EBSCO, Web of Science, Scopus, and PsycoInfo databases up to May 2021. We followed the PRISMA guidelines for systematic reviews. We included case-control and expression studies that provided data on mRNA expression and single-nucleotide polymorphisms of genes associated with SB. Results: A total of 21,926 individuals participated across 41 studies (not repeats); 34 studies provided data on single-nucleotide polymorphisms in 21,284 participants and 11 studies reported data on mRNA expression in 1034 participants. Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. Conclusions: Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB.
Genetics and Genomics of Reproductive Medicine
Authors: Tomaiuolo Rossella
Published: October 2021

The rapidity of innovations has meant that reproductive medicine today represents clear example of how complex but essential an adaptation of clinical practice and laboratory techniques to new knowledge is in the context of the dynamic evolution of medicine [...]
Novel Candidate Genes Differentially Expressed in Glyphosate-Treated Horseweed (Conyza canadensis)
Authors: Yang Yongil , Gardner Cory , Gupta Pallavi , Peng Yanhui , Piasecki Cristiano , Millwood Reginald J. , Ahn Tae-Hyuk , Stewart C. Neal
Published: October 2021

The evolution of herbicide-resistant weed species is a serious threat for weed control. Therefore, we need an improved understanding of how gene regulation confers herbicide resistance in order to slow the evolution of resistance. The present study analyzed differentially expressed genes after glyphosate treatment on a glyphosate-resistant Tennessee ecotype (TNR) of horseweed (Conyza canadensis), compared to a susceptible biotype (TNS). A read size of 100.2 M was sequenced on the Illumina platform and subjected to de novo assembly, resulting in 77,072 gene-level contigs, of which 32,493 were uniquely annotated by a BlastX alignment of protein sequence similarity. The most differentially expressed genes were enriched in the gene ontology (GO) term of the transmembrane transport protein. In addition, fifteen upregulated genes were identified in TNR after glyphosate treatment but were not detected in TNS. Ten of these upregulated genes were transmembrane transporter or kinase receptor proteins. Therefore, a combination of changes in gene expression among transmembrane receptor and kinase receptor proteins may be important for endowing non-target-site glyphosate-resistant C. canadensis.
Factors Associated with Hepatitis C Antibody Positivity in Korean Adults: A Cross-Sectional Study Based on 2013–2018 Korea National Health and Nutrition Examination Survey
Authors: Kim Taehui , Kim Jiyoung
Published: October 2021

This study aimed to provide basic data on the prevention of hepatitis C infection by identifying factors related to it based on the data from the National Health and Nutrition Examination Survey (KNHANES). The sixth (2013–2015) and seventh (2016–2018) Korean National Health and Nutrition Examination Surveys conducted by the Korean Disease Control and Prevention Agency were analyzed. This is a population-based, nationally representative, multistage, cross-sectional survey of noninstitutionalized persons in Korea. Multivariate regression analysis was used to assess the significance of the variables. A total of 32,942 persons aged >20 years were selected for this study. Among them, 282 tested positive for hepatitis C antibodies, while 32,660 tested negative. Of the 282 persons who tested positive, 48.6% were men and 51.4% were women. The factors associated with hepatitis C infection were age, education level, self-rated health status, and liver cirrhosis. Therefore, there is a need to educate people and implement preventive programs based on age and education levels to reduce the incidence of hepatitis C infections. In addition, it is necessary to include hepatitis C screening as part of the National Health Examination to diagnose hepatitis C infections.
Private Healthcare Expenditure in China: A Regional Comparative Analysis
Authors: Yang Shangguang , Wang Danyang , Xu Lu , Wang Chunlan , Yang Xi , Lo Kevin
Published: October 2021

Private (out-of-pocket) healthcare expenditure (PHCE) is a complex phenomenon that is shaped by many different factors. In this paper, we analyzed the influencing factors of PHCE in China, with a specific focus on regional differences. We found that old-age dependency ratio, income, and education have significant impacts on PHCE in all regions, whereas public HCE, number of beds in medical institutions, and economic development levels have significant impacts only in some regions. The results indicate that the government should pay attention to regional inequality and implement targeted adjustments for improving the health service system. In particular, we recommend: (1) monitoring regional inequality in PHCE and other healthcare issues to unmask geographical differences in healthcare interventions; (2) adopting regional-specific policy measures—the government should divert some resources from eastern to western and central regions to increasing the support for public health undertakings and improve the quality of the local health services while providing matching medical resources by targeting the needs of the residents; (3) paying more attention to the healthcare demand of the elderly population; and (4) improving the education level of residents to improve public health and avoid high PHCE.
Time-Slip Journey to Jomon Period: A Case Study of Heritage Tourism in Aomori Prefecture, Japan
Authors: Drianda Riela Provi , Aritenang Adiwan Fahlan , Zohrah Laila , Noda Yuri
Published: October 2021

This study focuses on Aomori, a prefecture situated in the northern part of the Japanese main island Honshu. Riding on the popularity of time-slip-themed entertainment, Aomori began to brand itself as a place where people can experience a time-travel journey to the Jomon, the Japanese prehistoric era. Through this study, we investigated the practice of Aomori to incorporate fantasy in its heritage tourism. Mixed-method research was used to retrieve and analyze information about Aomori and its Jomon-themed time-slip tourism, including desk research and word frequency analysis. While selling fantasy in tourism is a not-so-new topic, the Aomori case shed light on the alternative strategy that regional areas can consider. The prefecture showed us the prospect to combine fantasy and the local culture to attract younger tourists and dedicated pop-culture fans to visit the local attractions. It also demonstrated the potential of thematic fantasy in heritage tourism, especially archaeotourism, often perceived as boring by the younger generation. Additionally, the Aomori case indicated the importance of tourism infrastructure, creative marketing, and innovation in heritage tourism. It further signifies the importance of speeding up digital transformation for the future of heritage tourism.
Effect of Opposite Tooth Condition on Marginal Bone Loss around Submerged Dental Implants: A Retrospective Study with a 3-Year Follow-Up
Authors: Dorj Odontuya , Lin Hsi-Kuei , Salamanca Eisner , Pan Yu-Hwa , Wu Yi-Fan , Hsu Yung-Szu , Lin Jerry C-Y , Lin Chin-Kai , Chang Wei-Jen
Published: October 2021

Background: The objective of this study was to evaluate the effects of opposite tooth conditions on change in marginal bone level (MBL) around submerged dental implants. Materials and methods: The study included healthy patients with one or two implants. Structures opposite implants were either natural teeth (NT) or fixed restorations (FRs). MBLs were measured on digital periapical radiographs at the mesial and distal aspects of each implant. Results: Sixty implants were inserted by the 3-year follow-up. Mean MBLs for NT were 0.21 ± 0.33 mm before prosthetic loading and 0.30 ± 0.41 mm 3 years later (p = 0.001). Mean MBLs with FRs were 0.36 ± 0.45 mm before loading and 0.53 ± 0.50 mm 3 years later (p < 0.001). Changes in mean MBL from the 6-month follow-up to the 1- and 3-year follow-ups were statistically significant (p < 0.01) for implants opposite NT. However, changes in mean MBL from the 6-month follow-up to the 1-year (p = 0.161) and 3-year follow-ups (p = 1.000) were not significant for implants opposite FRs. Between baseline and the 3-year follow-up, MBL change was relatively small and did not differ regarding NT and FRs. Conclusion: Bone loss was greater if submerged dental implants were opposed by FRs. MBLs around submerged implants continued to change after 3 years if NT opposed implants.
Acceptability of Clinical Trials on COVID-19 during Pregnancy among Pregnant Women and Healthcare Providers: A Qualitative Study
Authors: Marbán-Castro Elena , Pons-Duran Clara , García-Otero Laura , Chen Haily , Herrera Luis Bernardo , Gil María del Mar , Goncé Anna , Ferriols-Pérez Elena , Rodríguez Miguel Ángel , Toro Paloma , Bardají Azucena , González Raquel , Menéndez Clara , Enguita-Fernàndez Cristina
Published: October 2021

Participation of pregnant women in clinical trials entails challenges mainly related to concerns about the risks for fetuses. We undertook a qualitative study from June to October 2020 to assess the acceptability of participating in COVID-19 clinical trials among pregnant women in Spain. Phenomenology and grounded theory were used as methodological approaches. Semi-structured interviews were conducted with 24 pregnant women and six healthcare providers. Women were unsure if pregnancy was a risk factor to acquire the infection or to develop severe disease and expressed the limited information they had received, which led to uncertainties and emotional suffering. They had concerns regarding participation in clinical trials on COVID-19, regardless of the drug under study. Healthcare providers alluded to the importance of involving pregnant women’s relatives at the recruitment visit of the clinical trial. These findings may be useful to facilitate pregnant women’s participation in clinical trials.
Evolution Characters and Influencing Factors of Regional Eco-Efficiency in a Developing Country: Evidence from Mongolia
Authors: Xia Bing , Dong Suocheng , Li Yu , Li Zehong , Sun Dongqi , Zhang Wenbiao , Li Wenlong
Published: October 2021

The sandstorm in 2021 in East Asia demonstrated the ecological issues that culminated for decades in Mongolia. Mongolia is facing challenges to realize green and sustainable development. This article aims to increase the understanding of eco-efficiency and its influencing factors in Mongolia and to provide a reference for similar developing countries and regions to achieve green and sustainable development. This article used the Slacks-Based Measure of Efficiency (SBM) model with advantages of dimension freedom and unit variable to estimate the economic efficiency and eco-efficiency of 22 provinces in Mongolia from 2007 to 2016; energy consumption and undesirable environmental outputs were taken as ecological/environmental indicators in the input and output system of regional eco-efficiency in Mongolia, combining traditional indicators of economic efficiency to build Mongolia’s eco-efficiency input–output framework. This article applied hot spot analysis and gravity center analysis to reveal the temporal and spatial evolution characters of eco-efficiency in Mongolia. Finally, the article applied panel Tobit regression to analyze the influencing factors of eco-efficiency. We were found that Mongolia’s eco-efficiency slightly improved from 0.7379 in 2007 to 0.7673 in 2016, lower than the economic efficiency. The high eco-efficiency provinces appeared in the capital Ulaanbaatar and its surrounding areas, showing an obvious spatial spillover effect. The low eco-efficiency provinces were mainly in the undeveloped western region. The relationship between per capita GDP and eco-efficiency was U-shaped and consistent with environmental Kuznets theory. Accelerating economic growth, optimizing population distribution, and improving energy structure and green technology can improve Mongolia’s eco-efficiency.
Self-Determination Competencies, (Dis)Agreement in Decision-Making, and Personal Well-Being of Adults with Mild Intellectual Disabilities in Hong Kong
Authors: Wong Phyllis King Shui , Chow Amy Yin Man
Published: October 2021

Background: The self-determination of people with an intellectual disability (ID) in the contexts of adulthood and Chinese culture is under-examined in the field of ID, even though the concept of self-determination has vigorously developed in recent decades. This study examined the relationship between self-determination competencies and the personal well-being of adults with mild ID in Hong Kong, as well as their personal goals and decision-making (dis)agreements with their significant others. Methods: We interviewed 170 participants using the AIR Self-Determination Scale—Chinese Version (AIR SDS-C) and the Personal Well-Being—Intellectual Disability (Cantonese) (PWI-C), along with a self-constructed questionnaire. Results: When the demographic characteristics were controlled, self-determination competencies correlated positively with personal well-being (r = 0.313, p < 0.001), diverse personal goals were identified, and agreement with significant others was dominant in both daily and major decision-making. Conclusions: A positive correlation between self-determination and personal well-being was confirmed in a Chinese population with mild ID. These findings expand the understanding of the types of personal goals and agreement patterns of people with mild ID and yield implications for further research and practices.
Performing Simulated Basic Life Support without Seeing: Blind vs. Blindfolded People
Authors: Martínez-Isasi Santiago , Jorge-Soto Cristina , Barcala-Furelos Roberto , Abelairas-Gómez Cristian , Carballo-Fazanes Aida , Fernández-Méndez Felipe , Gómez-González Candela , Nadkarni Vinay M. , Rodríguez-Núñez Antonio
Published: October 2021

Previous pilot experience has shown the ability of visually impaired and blind people (BP) to learn basic life support (BLS), but no studies have compared their abilities with blindfolded people (BFP) after participating in the same instructor-led, real-time feedback training. Twenty-nine BP and 30 BFP participated in this quasi-experimental trial. Training consisted of a 1 h theoretical and practical training session with an additional 30 min afterwards, led by nurses with prior experience in BLS training of various collectives. Quantitative quality of chest compressions (CC), AED use and BLS sequence were evaluated by means of a simulation scenario. BP’s median time to start CC was less than 35 s. Global and specific components of CC quality were similar between groups, except for compression rate (BFP: 123.4 + 15.2 vs. BP: 110.8 + 15.3 CC/min; p = 0.002). Mean compression depth was below the recommended target in both groups, and optimal CC depth was achieved by 27.6% of blind and 23.3% of blindfolded people (p = 0.288). Time to discharge was significantly longer in BFP than BP (86.0 + 24.9 vs. 66.0 + 27.0 s; p = 0.004). Thus, after an adapted and short training program, blind people were revealed to have abilities comparable to those of blindfolded people in learning and performing the BLS sequence and CC.
Correlation between Severity of Fetal Growth Restriction and Oxidative Stress in Severe Small-for-Gestational-Age Infants
Authors: Ashina Mariko , Kido Takumi , Kyono Yuki , Yoshida Asumi , Suga Shutaro , Nakasone Ruka , Abe Shinya , Tanimura Kenji , Nozu Kandai , Fujioka Kazumichi
Published: October 2021

Severe small-for-gestational-age (sSGA) infants exhibit increased mortality and morbidity. Oxidative stress is suggested to be involved in intrauterine growth restriction. This retrospective study aimed to evaluate the oxidative stress level at birth in an sSGA population. Sera of 28 sSGA (sSGA group) and 31 non-sSGA (control group) infants, born at our hospital between March 2017 and March 2020, were evaluated. Oxidative stress (derivative of reactive oxidative metabolites: d-ROM level), biological antioxidant potential (BAP) level, and the ratio of d-ROM/BAP level (oxidative stress index: OSI) were measured. The sSGA group had a significantly lower birth weight (BW), BW z-score, head circumference, and height than the control group (all p < 0.05). No significant difference was noted in the BAP level; sSGA infants exhibited a significantly higher d-ROM level than control infants. sSGA infants showed a significantly increased OSI compared with control infants, and the BW z-score was inversely correlated with d-ROM levels and OSI in sSGA infants (R2 = 0.300; p < 0.01 and R2 = 0.319; p = 0.02, respectively) but not in controls. In conclusion, sSGA infants, including preterm infants, exhibited higher oxidative stress at birth. The severity of fetal growth restriction was significantly correlated with oxidative stress levels at birth in sSGA infants.
Investigating Caesarean Section Practice among Teenage Romanian Mothers Using Modified Robson Ten Group Classification System
Authors: Matei Alexandra , Dimitriu Mihai Cornel , Roșu George Alexandru , Furău Cristian George , Ionescu Crîngu Antoniu
Published: October 2021

The Robson ten-group classification system is a recognized effective method of assessing caesarean rate. It is based on dividing patients into ten mutually exclusive groups, focusing on six maternal and newborn variables (parity, gestational age, plurality, foetal presentation, previous caesarean, and mode of labour onset). The aim of our analysis was twofold: first, to present the implementation of Robson classification in a pregnant teenage population; and second, to identify the indications for CS in the adolescent population. This study was designed as a one-year prospective analysis and considered all women younger than 20 years of age who delivered in a tertiary care hospital. Before discharge, women who had caesarean delivery responded to a questionnaire regarding their education, prenatal surveillance, and obstetrical history. Caesarean sections accounted for 47.01% of all births. A proportion of 24.57% of the participants had at least one previous caesarean section. Group 10 (all women with a single cephalic preterm pregnancy) was second most often identified among women in middle adolescence (14.03%); 32.20% of the participants in late adolescence were in group 5 (multiparas with a scarred uterus, single cephalic term pregnancy). Differences between the two age groups were not statistically different (p = 0.96). Abnormal cardiotocographic findings (38.23%), the arrest of descent (19.11%) and arrest of dilation (19.11%), were the most frequent indications for caesareans in Robson group 1. Neonates from mothers in Robson groups 8 (women with a multiple pregnancy) and 7 (multiparas single breech pregnancy) had the most unfavourable outcomes regarding gestational age at delivery and admission to the intensive care unit. We concluded that future focus on obstetrical management is mandatory in Robson groups 7 and 8. Adolescents in Robson group 1 (nulliparas, single cephalic term pregnancy, spontaneous labour) are the primary beneficiaries of strategies to reduce caesarean sections rates.