bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepciones sobre la política de seguridad democrática de Colombia en la frontera Tachira – Norte de Santander (2002-2010)
Authors: Bustamante Ana Marleny
Published: May 2021

El presente artículo evalúa los cambios en la percepción sobre la política de seguridad democrática de Colombia (PSD) y su efecto en la seguridad de la frontera de Táchira y Norte de Santander (TNS) durante el período 2002- 2010. Siguiendo la revisión teórica desde las disciplinas que confluyen en el análisis de la seguridad de las poblaciones fronterizas, su interrelación con el entorno local, nacional e internacional se realizó una investigación de tipo cualitativo con entrevistas a informantes para conocer sus percepciones y contrastarlas a la luz de la teoría y los constructos emergentes de la información cualitativa. Los resultados muestran la emergencia de tres categorías principales: Ambivalencia sobre la capacidad del Estado, oscilaciones en la credibilidad del Estado y pérdida de la calidad de vida. Dichas categorías se subdividen en dimensiones como fortalecimiento y debilidad del Estado, violencia, éxodo poblacional, desempleo, falta de acompañamiento con políticas de desarrollo, pérdida de libertades y seguridad pública y resiliencia, entre otras. En su conjunto evidencian que la PSD fortaleció relativamente la capacidad del Estado aunque aún necesita rescatar y construir institucionalidad y cambió percepciones sobre las dinámicas de seguridad fronteriza y de la vida en la frontera de TNS. Una evaluación más apropiada requiere mayor investigación a más largo plazo con el fin de evitar los matices y pasiones propios del momento; por lo tanto, es necesario continuar profundizando y evaluando tendencias sobre la PSD en las fronteras de Colombia.
Origin and Genetic Diversity of Nepalese Indigenous Goats (Capra hircus)
Authors: Gorkhali Neena Amatya , Lin Jiang , Sapkota Saroj , Pokhrel Bhoj Raj , Ma Yue-Hui , Han Jian-Lin
Published: May 2021

Background: A very little study has been conducted on the phylogenetic diversity of Nepalese indigenous goats where four breeds, Khari, Chyangra, Terai and Sinhal, have been identified. Methods: The 625-bp long sequences of the mitochondrial DNA hyper-variable region obtained from 93 goats in this study revealed high haplotype diversity among breeds, which come under four haplogroups (A-D). Result: The study demonstrated a certain level of gene flow among the neighboring goat populations exhibiting no correspondence between the geographic regions of origin and relationships among breeds. The complex mtDNA diversity and structure identified among indigenous Nepalese goats can be explained by gene flow through ancient trading and the current ‘free’ movement of goats across the geographic vicinities in India and China. Furthermore, HapG B showed the southward direction of gene flow which does not cross the Himalayas, whereas HapG B1 revealed the South-West gene flow from the claimed domestication center for HapG B, China, to Nepal.
Principal Component Analysis and Stability of Genotypes in French Bean (Phaseolus vulgaris L.)
Authors: Reddy B. Rajasekhar , Pandey Maneesh , Singh J. , Singh P.M. , Rai N.
Published: May 2021

Background: Principal component analysis and Finlay-Wilkinson stability analysis were carried out at research farm of ICAR-Indian Institute of Vegetable Research, Varanasi to identify diverse french bean genotypes for green pod yield and suitable genotypes for stable yield and yield related parameters. Methods: All the 24 genotypes were laid out in randomized block design with two replications during winter, 2017 and 2018. Principal component analysis and stability analysis was done to identify the diverse and stable genotypes. Result: Eight principal components were observed and the maximum variability was concentrated in the first three principal components PC1, PC2 and PC3 which contributed to 68.61% variance. Cluster analysis from principal component scores formed three clusters with a maximum of seventeen genotypes in cluster I followed by six genotypes in cluster II and one genotype in cluster III. High heritability was observed for 10 pod weight, number of pods per cluster and number of seeds per pod and moderate heritability was observed for yield per plant. Finlay-Wilkinson stability analysis identified the stable genotypes viz., FMGCV 1378, FMGCV 0958, Arka Suvidha, Valentino, Banoa and VRFBB-14-2 for green pod yield per plant, Cartagenta for pod length (cm) and Paulista, Slender Pack, Arka Suvidha, Valentino, FMGCV 0958, Banoa, FORC 6V 1136, VRFBB-14-1, VRFBB-14-2 for number of pods per plant.
PREVALENCE OF STRONGYLOIDES SP INFECTION IN BALI CATTLE IN MENGWI BADUNG AND BATURITI TABANAN OF THE BALI PROVINCE
Authors: Suastini Ni Ketut , Apsari Ida Ayu Pasti , Suratma Nyoman Adi
Published: May 2021

Penelitian ini bertujuan untuk mengetahui prevalensi infeksi Strongyloides sp. pada sapi bali di dataran rendah basah (Kecamatan Mengwi Badung) dan dataran tinggi basah (Kecamatan Baturiti Tabanan) Provinsi Bali. Jumlah sampel yang diteliti sebanyak 300 sampel, 150 berasal dari dataran rendah basah dan 150 berasal dari dataran tinggi basah. Sampel diperiksa dengan metode pengapungan menggunakan larutan gula jenuh sebagai larutan pengapung. Hasil penelitian dianalisis secara deskriptif menunjukkan prevalensi infeksi Strongyloides sp. pada sapi bali di Provinsi Bali sebesar 5% (15/300) yang berasal dari dataran rendah basah 2,7% (4/150) dan tinggi basah 7,3 % (11/150). Hasil analisis dengan uji chi-square, menunjukkan umur berhubungan dengan prevalensi infeksi Strongyloides sp. sedangkan jenis kelamin dan ketinggian wilayah tidak berhubungan dengan prevalensi infeksi Strongyloides sp.
PIGS CLUSTERIZATION BASED ON BODY WEIGHT IN PESANGGARAN SLAUGHTERHOUSE, OF DENPASAR
Authors: Maheswari Ni Putu Permata Dewi , Sampurna I Putu , Sukada I Made
Published: May 2021

Penelitian ini bertujuan untuk mengelompokkan babi yang dipotong di Rumah Pemotongan Hewan Pesanggaran berdasarkan bobot badan. Bobot badan babi menjadi salah satu hal yang penting, sebab bobot badan menentukan harga jual daging babi. Pengumpulan data dilakukan dengan pengukuran langsung bobot badan babi dan melakukan pendataan terhadap jenis kelamin, jenis babi, pakan, sistem pemeliharaan, umur, dan daerah asal babi tersebut. Data yang diperoleh dianalisis dengan deskriptif distribusi frekuensi kuantitatif, dilanjutkan dengan analisis klaster hierarki, dan dijelaskan dalam bentuk tabel keanggotaan klaster. Hasil penelitian terhadap 220 ekor babi yang dipotong di Rumah Pemotongan Hewan Pesanggaran diperoleh rata-rata bobot badan sebesar 109,64 ± 17,053 kg dan berdasarkan distribusi frekuensi komulatif, sebaran data tersebut masuk ke dalam kategori sebaran normal dan tidak ada faktor dominan yang memengaruhi variasi bobot badan babi tersebut. Dapat disimpulkan bahwa klaster bobot badan babi yang dipotong di Rumah Pemotong Hewan Pesanggaran diperoleh hasil lima keanggotaan klaster dan kelima keanggotaan klaster tidak dipengaruhi oleh jenis kelamin dan daerah asal babi termasuk jenis babi, umur, pakan, serta sistem pemeliharaan.
THE IMPACT ORAL ADMINISTRATION OF MINYAK RAJAS ON LIVER HISTOPATOLOGY AND AMINOTRANSPHERASE ACTIVITIES IN MALE KAMPONG CHICKEN
Authors: Teja Putu Tessa Hariys Septianda , Arjana Anak Agung Gde , Setiasih Ni Luh Eka , Merdana I Made
Published: May 2021

Penelitian ini dilakukan untuk mengetahui gambaran histopatologi hati dan aktivitas aminotransferase ayam kampung yang diberikan minyak rajas secara oral. Penelitian ini menggunakan sampel ayam kampung jantan fase grower umur 8 minggu dengan berat 500 – 800 g sebanyak 24 ekor. Hewan coba dibagi menjadi 4 kelompok perlakuan yaitu P0, P1, P2 dan P3 dengan tiap perlakuan terdiri dari 6 ekor hewan coba. Aklimatisasi terhadap semua hewan coba dilakukan selama 1 minggu dengan pemberian pakan ayam komersial dan air minum secara adlibitum terhadap semua kelompok. Selanjutnya minggu ke-2 sampai minggu ke-8, hewan coba dalam kelompok P1, P2 dan P3 diberikan minyak rajas sesuai dosis yang dicampur dengan pakan ayam komersial secara oral, sedangkan kelompok P0 diberikan placebo. Pemeriksaan kadar AST ALT dan pembuatan preparat histopatologi hati dilakukan pada minggu ke-5. Organ hati diambil secukupnya dan dimasukan ke dalam pot yang telah diisi dengan Neutral Buffer Formalin 10% untuk dibuat preparat histopatologi dengan pewarnaan Hematoxyilin-Eosin (HE). Variabel yang diamati dari sediaan histopatologi berupa nekrosis dan infiltrasi sel radang, kongesti dan degenerasi melemak. Data pemeriksaan sediaan histopatologi di analisis dengan uji statistik non parametrik Kruskal-Wallis dan uji Mann-Whitney, sedangkan data kadar AST dan ALT dianalisis dengan uji sidik ragam dan uji Duncan. Hasil penelitian menunjukan ditemukan adanya perubahan histapotologi hati serta kadar AST dan ALT ayam kampung jantan.
PREVALENCE AND RISK FACTORS OF STRONGYLOIDES PAPILLOSUS IN GOATS IN DENPASAR CITY
Authors: Handojo Chindi Meilina , Apsari Ida Ayu Pasti , Widyastuti Sri Kayati
Published: May 2021

Kambing merupakan salah satu ternak yang memiliki potensi besar untuk dikembangkan di Kota Denpasar. Namun, dalam pengembangannya terdapat beberapa kendala, salah satunya adalah penyakit parasitik yang disebabkan oleh nematoda gastrointestinal Strongyloides papillosus. Terdapat beberapa faktor yang memengaruhi infeksi nematoda ini pada kambing, di antaranya adalah; umur, jenis kelamin, jumlah kambing per kandang, ras/breed serta sistem perkandangan. Tujuan dari penelitian ini adalah untuk mengetahui prevalensi infeksi S. papillosus dan hubungannya dengan faktor risiko yang memengaruhi infeksi pada kambing yang dipelihara di Kota Denpasar. Sejumlah 150 faeses berbeda dari kambing yang dipelihara di Kota Denpasar diambil sebagai sampel pada penelitian ini. Pemeriksaan sampel dilakukan dengan metode apung dan data yang diperoleh dianalisis dengan analisis univariat dan bivariat berupa uji chi-square. Hasil penelitian menunjukkan prevalensi S. papillosus pada kambing yang dipelihara di Kota Denpasar adalah 24,7%. Uji chi-square mendapatkan bahwa umur dan jumlah kambing per kandang memiliki hubungan dengan prevalensi infeksi cacing S. papillosus, sedangkan jenis kelamin, breed serta sistem perkandangan tidak berhubungan dengan prevalensi infeksi cacing S. papillosus.
A Difficult Diagnosis of Plasmodium ovale Malaria
Authors: Santos-Reis Ana , Nina Jaime
Published: May 2021

Malaria is a major cause of suffering, disease, and death worldwide and is considered the most important of all human parasitic diseases. Malaria is still endemic in most tropical and sub-tropical areas and globalization has contributed to an increase of imported cases around the world. We report a Plasmodium ovale infection in a traveler with recent return from a long land trip across West Africa. He declared adherence to mefloquine chemoprophylaxis only at the start of the trip. Initially, he was seen at two different hospitals and in both he was screened for malaria by microscopy and rapid diagnostic test, but his diagnosis was not confirmed. The traveler was then diagnosed at our hospital with a malaria infection by Plasmodium ovale. Complete blood count showed mild anemia, but leukocytes and platelets were already normal. Symptoms resolved in 24 hours after treatment started. Microscopy of stained blood films remains the gold standard for malaria diagnosis, which is critically dependent on trained eyes. In non-endemic regions with few cases during the year, training programs in malaria microscopy are crucial. The aim is to prevent the reintroduction of malaria in Europe, reduce individual morbidity and suffering, and thus contribute towards reduction in deaths caused by this disease.
Recurrent decisions and innovation management in tourism
Authors: Brajdić Igor
Published: May 2021

A possible starting point when considering the theory of decision-making is offered in the concept of recurrence of problem situations as a concept which is in direct connection with innovative management. The importance of innovative management is present in all activities including too tourism. For the successful realisation of innovation in tourism two aims should be satisfied: • Foresee as much as possible non-recurrent problem situations. • Increase the number of self-occurring, non-recurrent problem situations. Decisions made by innovative managers, and especially top managers in tourism, who are often confronted with non-recurrent situations, and need to make non-structured decisions, can best be described using the descriptive model for decision-making. To enable the realisation of given goals of quality decision-making in management for Croatia's tourism it is necessary to depart from recurrent and self-transcendental systems (to which belongs also tourism), and include an intelligent support system for decision-making. To enable a practical realisation it is necessary to create and maintain a completely new culture of tourism management directed towards the concept of creativity and innovation.
Correction of the Koenig Formula for the Kinetic Energy of a Rotating Solid
Authors: Alyushin Yuriy
Published: May 2021

An exact solution is obtained for the kinetic energy in the general case of the spatial motion of solids with arbitrary rotation, which differs from the Koenig formula by three additional terms with centrifugal moments of inertia. The description of motion in the Lagrange form and the superposition principle are used, which provides a geometric summation of the velocities and accelerations of the joint motions in the Lagrange form for any particle at any time. The integrand function in the equation for kinetic energy is represented by the sum of the identical velocity components of the joint plane-parallel motions. The moments of inertia in the Koenig formula do not change during movement and can be calculated from the current or initial state of the body. The centrifugal moments change and turn to 0 when rotating relative to the main central axes only for bodies with equal main moments of inertia, for example, for a ball. In other cases, the difference in the main moments of inertia leads to cyclic changes in the kinetic energy with the possible manifestation of precession and nutation, the amplitude of which depends on the angular velocities of rotation of the body. An example of using equations for a robot with one helical and two rotational kinematic pairs is given.
Los Efectos de la terapia acuática VS la terapia en tierra en los trastornos motores en niños con parálisis cerebral: una Revisión Sistemática
Authors: Robles Zamorano Sheila , Llanos Tranque Cristina , Gómez Andrés Alba
Published: May 2021

Antecedentes: La Parálisis Cerebral (PC) es un conjunto de trastornos del desarrollo del movimiento y de la postura que causan limitación en la actividad. Es la discapacidad física más frecuente en la infancia. La fisioterapia toma un papel muy importante en la rehabilitación de estos pacientes. La hidroterapia aporta una gran estimulación sensorial y propioceptiva al sistema nervioso, proporcionando nuevas adaptaciones motrices. Esta terapia en niños tiene un gran valor lúdico y educativo. Objetivos: Revisar la efectividad de la terapia en el medio acuático en la función motora gruesa de los niños con PC, frente a las intervenciones en tierra. Método: Se ha realizado una revisión siguiendo los criterios PRISMA con búsquedas en PubMed, PEDro y WOS sobre el tratamiento en medio acuático de niños con PC. Se ha evaluado la calidad metodológica de estos a través de la escala PEDro. Resultados: Han sido seleccionados cinco artículos que cumplían los criterios de selección marcados. Existe mejora en la función motora gruesa e incluso se mantiene en un periodo de 10 semanas. El disfrute y adherencia en este medio es mayor frente en tierra. Conclusión: La intervención fisioterapéutica en el medio acuático aporta mayores beneficios en la función motora gruesa en niños con PC, frente a intervenciones realizadas en el medio terrestre.
La relación del método con el objeto de enseñanza en la escuela uruguaya ¿actividades acuáticas y/o natación?
Authors: Chirigliano Inés
Published: May 2021

Background: Throughout history, the teaching of water activities in our country has gone through various methodologies. Issue that in several cases was and is usually explained in a restricted way, mainly depending on the physical contexts where they develop and in them, attending to issues related to the number of students and teachers, available materials, and infrastructure, leaving aside teaching, and the different methodological ways to implement it. Objectives: This qualitative study set out to know and understand the methodologies used by teachers who teach aquatic activities in physical education in public schools, in the eastern area of Montevideo, Uruguay. Method: The research used two procedures: first, it made twelve non-participant observations of the classes of four teachers in the pool (three each), second, four semi-structured and in-depth interviews were conducted (one with each teacher). Results: The conclusions of the study reveal how teachers conceive of teaching, almost synonymously, swimming and aquatic activities, showing the same ways of teaching when it comes to a different object of study. Regarding the methodological, the observed panorama is quite homogeneous, characterized by analytical proposals, typical of traditional methods for teaching the sport of swimming. It is also observed, the majority use of descriptive and explanatory techniques, where decision-making is closer to the teacher than to the student. Conclusions: The conclusions reveal how teachers conceive of teaching, almost synonymously, swimming and aquatic activities, showing the same ways of teaching when it comes to a different object of study.
Quality of life in a randomized phase II study to determine the optimal dose of 3-week cycle nab-paclitaxel in patients with metastatic breast cancer
Authors: Taira Naruto , Kashiwabara Kosuke , Tsurutani Junji , Kitada Masahiro , Takahashi Masato , Kato Hiroaki , Kikawa Yuichiro , Sakata Eiko , Naito Yoichi , Hasegawa Yoshie , Saito Tsuyoshi , Iwasa Tsutomu , Takashima Tsutomu , Aihara Tomohiko , Mukai Hirofumi , Hara Fumikata
Published: May 2021

Background
To report our findings on quality of life (QoL) in a randomized phase II study to determine the optimal dose of 3-week cycle nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer (MBC).
Methods
Patients with HER2-negative MBC were randomly assigned to three different doses of q3w nab-PTX (SD: 260 mg/m2 vs. MD: 220 mg/m2 vs. LD: 180 mg/m2). QoL was assessed at baseline and during the 2nd, 4th and 6th courses of treatment using the Functional Assessment of Cancer Therapy-Taxane (FACT-Taxane), Cancer Fatigue Scale (CFS) and EuroQol 5-Dimension (EQ-5D). Comparisons were performed with mixed-model repeated-measures (MMRM).
Results
A total of 141 patients were enrolled in the parent study, and 136 (96%) (44, 45 and 47 in the SD, MD, and LD groups) were included in the analysis. MMRM analysis showed that the difference from the baseline FACT-Taxane trial outcome index at MD and LD were significantly higher than that at SD (MD vs. SD P < 0.001, LD vs. SD P < 0.001). Differences from baseline for FACT-Taxane total, physical and emotional well-being, and taxane subscale scores at MD and LD were also higher than at SD. The difference from baseline for the CFS score at LD was lower than at SD (P = 0.013) and those for EQ-5D utility scores at MD and LD were higher than at SD (MD vs. SD P = 0.011, LD vs. SD P < 0.001).
Conclusion
QoL of patients treated with 220 or 180 mg/m2 of q3w nab-PTX was significantly better than that of patients treated with 260mg/m2.
Trial registration:
The protocol was registered at the website of the University Hospital Medical Information Network (UMIN), Japan (protocol ID: UMIN000015516), on 01/11/2014. Details are available at the following address:
Experiment Regarding Magnetic Fields with Gravity
Authors: Lee Jong-hoon
Published: May 2021

The ground-based device simulates the potential energy (voltages) between gravity and magnetic seas. The gravity generator (GG) generated currents and voltages on the mesoscopic scale in the vacuum. Gravity interacts to generate electricity in the Earth's direction or the opposite direction by the repulsive magnetic force. A trapped gravity was set to behave as free relativistic quantum particles or fluids, which made it possible to measure the particle position as a function of time. Our result is grounded on a rigorous proof based on numerical and analytic computations, which took it accessible to study the magnetic sea for different initial superposition of positive- negative-gravity spinor state. It might explain the relativistic quantum gravity and the heating mechanism of the Sun.
Association between MTHFR C677T polymorphism and the susceptibility to nonsyndromic cleft lip with or without cleft palate in Chinese Han population: a case-control study and meta-analysis
Authors: Lu Xuemei , Deng Xiaoling , Liu Tingying , Zhang Qiufang , Xu Mingyan
Published: May 2021

Background: Functional polymorphisms on methylenetetrahydrofolate reductase (MTHFR) gene are reported to be involved in the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P), but the conclusions are still inconsistent. The aim of our study is to investigate the association between the susceptibility of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and MTHFR C677T polymorphism in Chinese Han population．Methods: A case-control study was performed, followed by a Meta-analysis. Electronic databases including PubMed, Embase, CNKI, VIP and Wanfang database were searched for relevant literature from inception of databases to November 2020. Meta-analysis was performed using Revman 5.3 and STATA 12.0 software. Results: The case-control study included 358 NSCL/P cases and 354 controls, which indicated that the variant T allele significantly increased NSCL/P risk in Southern China. Then, in the present Meta-analysis, a total of nine case-control studies with 1444 cases and 1555 controls were included. Overall, there was a significant association between MTHFR C677T polymorphism and NSCL/P susceptibility under all genetic models. The subgroup analysis of NSCL/P types showed significantly increased risk of CLO but not CPO or CLP. In terms of the stratified analysis by geographical location, a significantly association was observed in Southern China under all genetic models, while there was no significant association in Northern China. Sensitivity analyses, Begg's funnel plot and Egger’s regression test further suggest the stable and trustworthy of these results. Conclusion: MTHFR C677T polymorphism is associated with the risk of NSCL/P in Chinese Han population, especially increasing the risk of NSCL/P in southern Chinese Han populations.
Predicting LQ45 Financial Sector Indices using RNN-LSTM
Authors: Hansun Seng , Young Julio Christian
Published: May 2021

As one of the most popular financial market instruments, the stock has formed one of the most massive and complex financial markets in the world. It could handle millions of transactions within a short period and highly unpredictable. In this study, we aim to implement a famous Deep Learning method, namely the Long Short-Term Memory (LSTM) networks, for the stock price prediction. We limit the stocks to those that are included in the LQ45 financial sectors indices, i.e., BBCA, BBNI, BBRI, BBTN, BMRI, and BTPS. We propose to use a simple three layers LSTM network architecture in predicting the stocks’ closing prices and found that the prediction results fall in the reasonable forecasting category. It is worthy to note that two of the considered stocks, i.e., BBCA and BMRI, have the lowest MAPE values at 19.1020 and 18.6135 which fall in the good forecasting results. Hence, the proposed LSTM model is recommended to be used on those two stocks.
Influence of The Expression Vector And of Its Elements On Recombinant hPRL Bacterial Synthesis: The Co-Directional Orientation of Replication And Transcription is Highly Critical
Authors: Affonso Regina , Suzuki Miriam Fussae , Magalhães Geraldo Santana , Bartolini Paolo
Published: May 2021

The aim of the present work was to define a bacterial expression system that is particularly efficient for the synthesis of human prolactin (hPRL). In previous work, the synthesis of rec-hPRL by the p1813-hPRL vector in E. coli HB2151 was >500 mg/L, while it was much lower now (2.5-4-fold), in the strains RB791 and RRI. The highest positive influence on rec-hPRL synthesis was due to the transcription-replication co-orientation of hPRL cDNA and the ori/antibiotic resistance gene, responsible for up to a ~5-6-fold higher expression yield. In conclusion, this work confirmed that each bacterial strain of E. coli has a genetic set that can allow a different level of heterologous protein synthesis. The individual study of each element indicated that its action critically depends on the reading orientation in which it is located inside the vector: co-directional orientation of replication and transcription, in fact, greatly increased the level of rec-hPRL expression.
Study of teenage students’ musculoskeletal health, teenage students training program: the application of intervention mapping approach to Develop Implementation Strategies
Authors: NeJhaddadgar Nazila , Tavafian Sedigheh Sadat , ziapour arash , Abbas Jaffar , Jamshidi Ahmad Rreza
Published: May 2021

Background: According to the studies conducted, teenage and its related health issues are of the most significant issues. The purpose of the study was to develop a Musculoskeletal Health intervention-training program using intervention mapping approach (IMA)for teenagers 12 to 14 years old.Methods: The present study is a study protocol where IMA has been used as a planning framework for developing musculoskeletal Health intervention-training program. Six intervention mapping steps have been completed in the study. As the first step, needs assessment has been performed by systematic review and qualitative evaluation . In the second step, matrix of change objectives was designed. Later on, after designing the program and planning the program implementation, the program evaluation plan was developed.Results: IMA guided us in designing and implementing a control-oriented training program with the participation of the participants along with the definition of outcomes, performance goals and determinants, theoretical methods and practical applications, intervention program, implementation and step by step assessment.Conclusion: Intervention mapping is a participation-based approach to design and implement promotion programs.
Tunable Multi-Frequency Optoelectronic Oscillator Based on a Microwave Photonic Filter and an Electrical Filter
Authors: Zhang Jin , Wang Yalan , Li Xiang , Liu Zhuangzhuang , Wo Jianghai
Published: May 2021

We propose and experimentally demonstrate a multi-frequency optoelectronic oscillator (OEO) based on phase-modulation to intensity-modulation (PM-IM) conversion. A microwave photonic filter (MPF) incorporating an optical fiber Bragg grating Fabry-Perot (FBG-FP) filter and an electrical yttrium iron garnet (YIG) filter in two branches are used to select the oscillation modes of the OEO. By adjusting the wavelength of laser source or the central frequency of YIG filter, two frequencies can be tuned independently within a wide range. The single sideband (SSB) phase noises of the generated frequencies are measured experimentally. Moreover, the OEO shows potential ability to achieve more frequencies oscillation by multiplexing more optical and electrical filters.
New Classification Based on CT and Its Value Evaluation for Fractures of the Lateral Process of the Talus
Authors: Wang Yuchuan , Deng Xiangtian , Zhu Yanbin , Wang Zhongzheng , Fu Lei , Chen Wei , Zhang Yingze
Published: May 2021

Background : The common classifications of the fractures of the lateral process of the talus（LTPFs）are based on radiographs and may underestimate the complexity of LTPF, therefore. The aim of this study was to propose a comprehensive CT-based classification system, and to evaluate its prognostic value, reliability and reproducibility.Material and Methods: We retrospectively reviewed 42 patients involving LTPF and clinical and radiographic evaluations were performed at an average follow-up of 35.9 months. In order to create a comprehensive classification, a panel of experienced orthopedic surgeons discussed the cases. All fractures were classified according to Hawkins, McCrory-Bladin and new proposed classification system by four surgeons. The analysis of interobserver and intraobserver agreements was done using kappa statistics.Results: This new classification included two types based on presence of concomitant injuries or not, with type I consisting of three subtypes and type II of five subtypes. Average AOFAS score was 91.5 in the type Ia of new classification proposed, 86 in type Ib, 90.5 in type Ic, 89 in type IIa, 76.7 in type IIb, 76.6 in type IIc, 91.3 in type IId, and 83.5 in type IIe. Interobserver and intraobserver reliability of the new classification system were almost perfect (κ=0.846 and 0.823, respectively)，showing a higher interobserver and intraobserver reliability compared to the Hawkins classification (κ=0.737 and 0.689, respectively) as well as McCrory-Bladin classification (κ=0.748 and 0.714, respectively). Conclusion: The new classification system is a comprehensive one that takes into account concomitant injuries and it shows good prognostic value with clinical outcomes. It is more reliable and reproducible and could be a useful tool for decision-making on treatment options for LTPFs.
Recurrent transperineal aggressive angiomyxoma: a case report
Authors: Li Xiaoli , Zhou Chunxia , Lin Jun
Published: May 2021

Background: aggressive angiomyxoma is a rare disease that may cause misdiagnosed in the clinical work and the characteristic of this disease is low potential malignancy. This case show a recurrent case of aggressive angiomyxoma 7 years after the surgery which was mistakenly diagnosed at that time.Case presentation: the patient presented a large mass in the right labium majus without any pain. This mass was recurrent 7 years after she received a surgery about the mass occurred at the same place which was diagnosed as vulvar angiomyofibroblastoma. She took the ultrasound scan and MRI scan and underwent the surgery again. This mass was excision completely. At this time, pathologist checked the HE stained slides and immunohistochemistry staining slides, then come the conclusion that this mass was aggressive angiomyxoma. We rechecked the pathological slides 7 tears ago and found out it was misdiagnosed at that time.Conclusions: Aggressive angiomyxoma is a rare tumor. This case presents a rare disease that may be misdiagnosed as other benign vulvar disease even after the surgery which get pathologic evidence. So we need to know more abou this disease.
Honey Bees Extract Map Coordinates from the Dance
Authors: Wang Zhengwei , Chen Xiuxian , Becker Frank , Greggers Uwe , Walter Stefan , Werner Marleen , Gallistel Charles , Menzel Randolf
Published: May 2021

Honeybees communicate locations by the waggle dance, a symbolic form of information transfer. Here we ask whether the recruited bee uses only the indicated course vector or translates it into a location vector on a cognitive map. Recruits were captured on exiting the hive and displaced to distant release sites. Their flights were tracked by radar. Both the vector portions of their flights and the ensuing tortuous search portions were strongly and differentially affected by release site. Search patterns were biased toward the true location of the food and away from the location given by adding release-site displacement to the danced vector. The results imply that the bees recruited by the dance access the indicated location of the food on a shared spatial representation. Thus, the bee dance communicates two messages, a flying instruction and a map location.
Thermodynamics of Ideal Gas at Planck Scale with Strong Quantum Gravity Measurement
Authors: Lawson Latevi Mohamed
Published: May 2021

More recently in J. Phys. A: Math. Theor. 53, 115303 (2020), we have introduced a set of noncommutative algebra that describes the space-time at the Planck scale. The interesting significant result we found is that the generalized uncertainty principle induced a maximal length of quantum gravity which has different physical implications to the one of generalized uncertainty principle with minimal length. The emergence of a maximal length in this theory revealed strong quantum gravitational effects at this scale and predicted the detection of gravity particles with low energies. To make evidence of these predictions, we study the dynamics of a free particle confined in an infinite square well potential in one dimension of this space. Since the effects of quantum gravity are strong in this space, we show that the energy spectrum of this system is weakly proportional to the ordinary one of quantum mechanics free of the theory of gravity. The states of this particle exhibit proprieties similar to the standard coherent states which are consequences of quantum fluctuation at this scale. Then, with the spectrum of this system at hand, we analyze the thermodynamic quantities within the canonical and micro-canonical ensembles of an ideal gas made up of N indistinguishable particles at the Planck scale. The results show a complete consistency between both statistical descriptions. Furthermore, a comparison with the results obtained in the context of minimal length scenarios and black hole theories indicates that the maximal length in this theory induces logarithmic corrections of deformed parameters which are consequences of a strong quantum gravitational effect.
Protective PEEP and Lung Capacity May Be Determined by a Rapid PEEP-step Procedure
Authors: Grivans Christina , Stenqvist Ola
Published: May 2021

Background: A protective ventilation strategy should be based on assessment of lung mechanics and transpulmonary pressure, as this is the pressure that directly “hits” the lung. Esophageal pressure has been used for this purpose but has not gained widespread clinical acceptance. Instead, respiratory system mechanics and airway driving pressure have been used as surrogate measures. We have shown that the lung P/V curve coincides with the line connecting the end-expiratory airway P/V points of a PEEP trial. Consequently, transpulmonary pressure increases as much as PEEP is increased. If the change in end-expiratory lung volume (ΔEELV) is determined, lung compliance (CL) can be determined as ΔEELV/ΔPEEP and ΔPTP as tidal volume times ΔPEEP/ΔEELV. Methods: In ten patients with acute respiratory failure, ΔEELV was measured during each 4 cmH2O PEEP-step from 0 to 16 cmH2O and CL for each PEEP interval calculated as ΔEELV/ΔPEEP giving a lung P/V curve for the whole PEEP trial. Results: Lung P/V curves showed a marked individual variation with an overall lung compliance of 43–143 ml/cmH2O (total inspiratory volume divided by end-inspiratory transpulmonary plateau pressure at PEEP 16 cmH2O). The two patients with lowest lung compliance were non-responders to PEEP with decreasing lung compliance at high PEEP levels, indicating over-distension. Patients with higher lung compliance had a positive response to PEEP with successively higher lung compliance when increasing PEEP. A two-step PEEP procedure starting from a clinical PEEP level of 8 cmH2O gave almost identical lung P/V curves as the four PEEP-step procedure. The ratio of airway driving pressure (ΔPAW) to transpulmonary driving pressure (ΔPTP/ΔPAW) varied between patients and changed with PEEP, reducing the value of ΔPAW as surrogate for ΔPTP in individual patients. Conclusion: Separation of lung and chest wall mechanics can be achieved without esophageal pressure measurements if ΔEELV is determined when PEEP is changed . Only a two-step PEEP procedure is required for obtaining a lung P/V curve from baseline clinical PEEP to end-inspiration at the highest PEEP level, which can be used to determine the PEEP level where transpulmonary driving pressure is lowest and possibly least injurious for any given tidal volume.Trial registration: ClinicalTrials.gov, NCT04484727. Registered 24 July 2020 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04484727?term=Lindgren%2C+Sophie&cntry=SE&draw=2&rank=1
Surface Chemistry Studies of Emission and Thermal Behaviour of Developed Composites for Building Ceiling Materials
Authors: DIRISU JOSEPH OSEKHOGHENE , Oyedepo Sunday , Fayomi Ojo , Salawu Enesi , Oyekunle John , Asere Abraham , Efemwenkiekie Kelvin
Published: May 2021

The emission of harmful elements from burning building ceiling materials and their attendant health effects on inhabitants within the vicinity of the emitted harmful elements is increasingly becoming a source of concern globally. Hence, the need to develop eco-friendly flame-retardant composite materials suitable for house ceiling purposes to forestall unwanted toxic emissions. This work identified the chemical structure of developed composite products and their emission performance during combustion. X-ray Diffraction (XRD) analysis was used for phase quantification and E550 combustion gas analyzer for emission characterization of the developed composites. Thermolyne 950oC oven was employed for the combustion analysis of the prepared composite at 500oC. Quasi negligible SO2 level and CO2 exist; however, A4, 0.3Aldr0.23Cmt0.3Si0.05G0.12CS recorded maximum CO level, an indication of toxic affluence. The low mass losses of all of the composite materials, especially for A2, 0.6Aldr0.34Cmt0.05G0.01OBSretard significantly due to its activities by the retardant constituent. The flame retardant nature of all produced composite was evidenced in their elemental composition, as there was an absence of flammable element and presence of stable insulating compound providing retardance to flame occurrences. These suppressions in the flame inclination of the reinforced materials were noticed within the boundaries of the ceiling crystals from the structural examination. The intermetallic phase from the diffraction intensities showed the presence of a significant second bond interstitial solid-phase across the matrix, especially for 0.6Aldr0.34Cmt0.05G0.01OBS ceiling material.
Divergent Metastatic Patterns Between Esophageal Squamous-cell Carcinoma and Esophageal Adenocarcinoma: a Propensity-matched Analysis
Authors: Liu Ganwei , Yang Feng , Wang Shaodong , Li Jianfeng , Zhou Zuli
Published: May 2021

Background: To explore the different metastatic patterns between esophageal squamous-cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).Methods: For this propensity-matched analysis, we used data from the latest iteration of the Surveillance, Epidemiology, and End Results (SEER) database and included patients diagnosed with esophageal cancer from 2010 to 2017. Results: A total of 20,189 patients were identified, including 6,610 ESCC and 13,579 EAC. After propensity score matching, 4597 pairs were selected. Compared with ESCC, EAC had a higher rate of liver metastasis (P < 0.001) and brain metastasis (P < 0.001), and a lower rate of lung metastasis (P < 0.001), with no signiﬁcant diﬀerence in bone metastasis (P = 0.255). The liver preferentially co-metastasized with lung in both cohorts. Brain metastasis was commonly observed in combination with other organ metastases in EAC. Conclusions: There are major differences in metastatic patterns between ESCC and EAC. The patterns identified may reflect the underlying biology of metastatic esophageal cancer and have potential to influence future monitoring strategies depending on clinical settings.
Decreased Sperm Motility is Associated with Increased Seminal Plasma IGF-I, IGF-II, IGFBP-2 and PSA Levels in Male Infertility
Authors: Fu Li , Yuen Kevin , Tint Aye Nyein , Hoffman Andrew R. , Bongso Ariff T. , Lee Kok Onn
Published: May 2021

PurposePrevious studies have suggested the involvement of serum IGFs and IGFBPs in the regulation of the female reproductive system. Little is known of these peptides in the seminal plasma (SP) of men and their potential effects on fertility. We assessed SP levels of these peptides in infertile men with low sperm motility (asthenozoospermic; AZ) and low sperm counts (oligozoospermic; OZ), its effects on in vivo sperm motility, and whether aging affects these peptides.MethodsTwenty eight infertile men (AZ; n = 18 and OZ; n = 10) and 20 fertile normozoospermic (NZ) men were studied. Seminal plasma IGF-I, IGF-II, IGFBP-2, IGFBP-3 and PSA levels were measured, and spermatozoa mRNA transcript patterns were examined.ResultsAsthenozoospermic men had higher SP IGF-I, IGF-II, IGFBP-2 and PSA levels than NZ and OZ men (all P < 0.05), whereas SP IGFBP-3 levels were no different between the three groups. Sperm count positively correlated with SP IGF-I, IGF-II and IGFBP-2; sperm motility negatively correlated with SP IGF-II and IGFBP-2; and age correlated positively with SP IGF-II (all P < 0.04). The expression of IGF-I and IGF-II mRNA and mRNA receptors was detectable, but no variations in transcript levels were noted. ConclusionDecreased sperm motility, but not sperm count, in infertile AZ men is associated with increased SP IGF-I, IGF-II, IGFBP-2 and PSA levels. Changes in SP IGFs and their interactions with IGFBPs and IGF receptors, and PSA levels suggest a role of these SP peptides in modulating sperm motility and possibly prostate disease development in aging men.
Identification and functional analysis of bacteria in sclerotia of Cordyceps militaris
Authors: Luo Li , Zhou Jia-Xi , Xu Zhong-Shun , Gao Ying-Ming , Zou Xiao
Published: May 2021

Background
Cordyceps militaris is a fungus that parasitizes insects. Compounds from C. militaris are valuable in medicine and functional food. There are many kinds of bacteria in the natural sclerotia of C. militaris. However, the community structure of microorganisms in samples from different places may be different, and the corresponding ecological functions require experimental verification.
Results
We used high-throughput sequencing technology to analyze bacterial 16S rRNA gene sequences in sclerotia of three samples of C. militaris from Liaoning Province, China. Pseudomonas, Pedobacter, Sphingobacterium, and Serratia were the dominant bacterial genera in the sclerotia. Pseudomonas and Pedobacter are heterotrophic, Sphingobacterium decomposes urea, and Serratia reduce nitrate. Two strains of bacteria, N-2 and N-26, were isolated from the sclerotia of the C. militaris, cultured, biochemically characterized, and identified as Stenotrophomonas maltophilia and Pseudomonas baetica, respectively. When these isolated strains were respectively cocultured with C. militaris, the mycelium biomass, mycelium pellet diameter, and cordycepin content decreased.
Conclusions
Bacteria in sclerotia have an important effect on the growth of C. militaris and the production of its metabolites.
miR-17-5p promotes the invasion and migration of colorectal cancer by regulating HSPB2
Authors: Yu Weifang , Wang Jia , Li Chao , Xuan Mingda , Han Shuangshuang , Zhang Yingfu , Liu Pengfei , Zhao Zengren
Published: May 2021

MicroRNA (miRNA) can affect tumor progression by regulating cell proliferation, apoptosis and metastasis. A significant upregulation of miR-17-5p expression was found in colorectal cancer (CRC) tissues by miRNA microarray chip analysis. However, the underlying mechanism of miR-17-5p in CRC is still unclear. The mRNA expression of miR-17-5p was significantly higher in CRC tissues than in adjacent normal tissues. In CRC group, the expression of miR-17-5p in cancer tissues with lymph node metastasis was higher compared with those without lymph node metastasis. The biological function of miR-17-5p was demonstrated through CCK-8, colony formation, flow cytometry and transwell assays. Overexpression of miR-17-5p inhibited CRC cell apoptosis, as well as promoting proliferation, migration and invasion. Transcriptome sequencing and miRNA target prediction software suggested that HSPB2 might be a target gene of miR-17-5p and luciferase reporter detection validated for the first time that miR-17-5p binds directly to the 3'-UTR of HSPB2. In the rescue experiment, the tumor suppressive effect of HSPB2 was detected and miR-17-5p could promote cell proliferation, migration and invasion by targeting HSPB2. Taken together, miR-17-5p promotes invasion and migration by inhibiting HSPB2 in CRC, thereby implicating its potential as a novel diagnostic biomarker and therapeutic target for CRC.
ANOSMIA IN COVID-19 INFECTION - A CASE SERIES
Authors:   Senior Resident, Department of E.N.T., Symbiosis Medical College for Women & Symbiosis University Hospital and Research Centre, Symbiosis International (Deemed) University (SIU), Lavale, Pune, Maharashtra, India - 412115., Mahesh Mohanty Roshni , Satyaprakash Gupta Anuya ,   Senior Resident, Department of E.N.T., Symbiosis Medical College for Women & Symbiosis University Hospital and Research Centre, Symbiosis International (Deemed) University (SIU), Lavale, Pune, Maharashtra, India - 412115.
Published: May 2021

Background:The aim of this study is to highlight anosmia as an important symptom to predict SARS-CoV-2 infection. The presentation of the disease commonly includes fever, cough, weakness, myalgia and breathlessness making anosmia a rare symptom. Methods:We included a total of 10 patients in the study who were between the age group of 18-70 years with the complaints of anosmia. Results:8 out of the 10 patients had come with fever and cough initially and developed anosmia later. However, 2 patients had presented to us with anosmia alone as the first symptom and then on further evaluation were found to be COVID-19 positive. The available clinical data was collected, recorded and the results were analyzed. Conclusion:Anosmia is a rare or late, but contributory symptom of the coronavirus disease. Thus, clinicians should keep in mind the diagnosis of COVID-19 while treating patients presenting with such atypical symptoms for early detection & in-time treatment of COVID 19 infection to prevent complications associated with the disease.
THE RELATION OF HUMOR TO DEPRESSION AND PERSONALITY
Authors: Saleh Almahdi Intesar
Published: May 2021

Background:Depression is a common illness in the world.Humor plays an important role in mental health filed as a coping mechanism. Different personality variables seem to be factors associated with depression. Therefore, in this study, we aimed to study the relationship among different personalities and coping humor which may lead to identified associated depression Methodology:An online website of the questionnaires was created for data collection using three scales combined: Coping humor scale (CHS), Zung depression scale, Eysencks Personality Inventory (EPI) which was conducted on a convenience sample population of at least 200 college students participants from King Faisal University. After conducting the research, the data was collected, analyzed and processed in tables using the appropriate statistical measurements, in return the results were given and concluded. Results: We collected data from 502 participants with mean age 23.6 Ã‚Â± 3.5 years old and 74.3 % of participants were females. The mean scores of CHS, depression scales, extraversion/introversion and Neuroticism/emotional stability were 20.27 (out of 28), 44.42 (out of 80), 18.27 (out of 24), and 10.99 (out of 24).There is a significant negative correlation between coping humor scale and depression scale (P=0.00). Conclusion:There is a significant negative correlation between depression and coping of humor among students in Al Alahsa, Saudi Arabia. Moreover, extraverted participants and emotional stable participants were associated with higher usage of humor to cope and less level of depression.