bluuebunny/crossref_metadata_2025 huggingface dataset:
Introdução à acessibilidade urbana: um guia prático em R
Authors: Pereira Rafael H. M.
Published: April 2024

O objetivo deste livro é equipar seus leitores com os conceitos fundamentais e as ferramentas de análise e processamento de dados necessários para realizar análises de acessibilidade urbana e conduzir avaliações de impacto de projetos e políticas de transporte. O livro foi escrito pensando nas necessidades de trabalho de gestores públicos, analistas, alunos e pesquisadores de planejamento e transporte urbano, e, por isso, possui caráter prático. Todo o material do livro é apresentado com exemplos reproduzíveis e dados abertos, utilizando para isso a linguagem de programação R.
A Review on Natural Gas Origin and Composition
Authors: Kaur Harpreet
Published: April 2024

Natural gas is obtained naturally. It is a hydrocarbon mixture. Natural gas is clean fossil fuel. It is safe when transported. Methane is main constituent of natural gas. It may also contain higher order hydrocarbons, carbon dioxide, helium, hydrogen sulphide and noble gases. World is facing problem of environmental pollution. To combat menace of pollution alternative sources of energy should be used. Natural gas is the cleanest fuel. Demand of natural gas all over the world is increasing.
La subversión socrática, de Óscar Velásquez
Authors: Ugalde Benjamín
Published: April 2024

Reseña de Benjamín Ugalde del libro La subversión socrática, de Óscar Velásquez. Santiago: Ediciones Universidad Diego Portales, 2023.
Comparative antimicrobial evaluation of synthetic antibiotics and essential oils against human pathogenic bacteria and fungi
Authors: Khaliq Ayman , Mishra Akhilesh Kumar , Rabbani Ahmad
Published: April 2024

In pathological conditions, surgeries, or immunodeficiency, opportunistic pathogens that normally coexist harmlessly within the human body can escalate the human system, leading to infections ranging from mild to life-threatening. Combatting such infections requires reliance on either natural or synthetic antimicrobial molecules. Plant secondary metabolites, particularly essential oils, present a potential natural remedy for addressing these infections. The study aimed to qualitatively and quantitatively assess the efficacy of eight synthetic drugs and three essential oils against various pathogenic bacteria and fungi, including Staphylococcus aureus, Staphylococcus epidermidis, Mycobacterium smegmatis, Enterococcus faecalis, Malassezia furfur, and Candida albicans (K4-1). Our results showed that penicillin was highly effective against S. aureus and E. faecalis, while gentamicin was effective against S. epidermidis. Vancomycin exhibited antimicrobial activity against all bacteria except S. epidermidis. Notably, clotrimazole and amphotericin-B demonstrated potent inhibition of fungal pathogens. Essential oils, particularly lemongrass displayed prominent zones of inhibition against all the examined pathogens including the resistant strains. Palmarosa oil showed substantial inhibition at a concentration of 3% v/v.
Genotypic variation in flowering, fruit set, and cherelle wilt, and their relationship with leaf nutrient status in cocoa (Theobroma cacao L.) grown in humid tropics of India
Authors: Bhavishya  , Bhat Ravi , Apshara S. Elain , Pushpa T. N. , Prasad D. Srikanta , Nayana H. , Thube S. H. , Pandian R. T. P. , Ramesh S. V.
Published: April 2024

Cocoa is an important plantation crop grown for its beans, used in the chocolate and confectionary industry. It produces a large number of perfect flowers on the stem (cauliflorous), but the fruit set is low. There is a lack of comprehensive information regarding the genotypic variability in flowering, fruit set, and cherelle wilt, as well as their relationship with leaf nutrient status. Thus, a field study was undertaken at ICAR-Central Plantation Crops Research Institute, Regional Station, Vittal, to elucidate the influence of leaf nutrient status on flowering, fruit set, and cherelle wilt in cocoa. The study revealed significant variations among twenty cocoa genotypes for flower production, fruit set, and cherelle wilt. The highest number of flowers (106) produced on a one-meter marked area on the stem and fruit set (13.7) was recorded in VTLC 05. The lowest number of flowers was observed in genotype VTLCH 2 (16). The maximum fruit set percentage was found in VTLC 182 (13.8%), whereas the minimum fruit set percentage was observed in VTLC 30A (1.3%). Cherelle wilt was maximum in upper Amazon clone VTLC 155 (72.9%), whereas the lowest cherelle wilting percentage was recorded in VTLC 148 (22.9%). Pearson’s correlation coefficients indicated that fruit setting percentage in different genotypes had no significant association with leaf nutrient status, except for calcium which had a significant association (r = 0.596). The result indicated that genotypic variability exists for fruit set and cherelle wilt, and an optimum level of calcium should be maintained in the leaf for better fruit setting in cocoa.
Morphological and molecular diversity of eggplant accessions (Solanum melongena L) using simple sequence repeats (SSR) markers
Authors: Musa Ibrahim , Yusop Mohd Rafii , Magaji Usman , Chukwu Samuel Chibuike , Muhammad Isma’ila , Ayanda Arolu Fatai , Rini Bashir Yusuf , Kiri Audu Sanusi
Published: April 2024

The evaluation of various desirable traits in eggplant genotypes has facilitated the efficient process of selecting and improving them. Morphological parameters have proven to be valuable in assessing the similarities or differences among different accessions, while molecular data have been used to support the conclusions drawn from the morphological analysis. This study was conducted to evaluate the performance of 42 eggplant genotypes collected from Malaysia, China, and Thailand. The characteristics under investigation were shown to be highly significant (p < 0.01) by analysis of variance (ANOVA). It was noted that the plants TV17 (5.59 kg) and MV18 (5.97 kg) produced large yields per plant. The SSR markers used exhibited moderate average values for the number of alleles (2.53). The major allele frequency displayed a high average value (0.53) and a moderate average number of effective alleles (2.31). Additionally, the observed Shannon’s information index, expected heterozygosity, and PIC were high (0.84, 0.54, and 0.45, respectively). Using the unweighted pair-group approach with arithmetic averages based on similarity matrices (UPGMA) Dendrogram, 42 accessions were sorted into five primary groups based on similarities. The findings of this study indicate that the use of simple sequence repeat (SSR) markers can effectively estimate genetic diversity and analyze phylogenetic relationships. Moreover, these markers can assist eggplant breeders in selecting desirable quantitative traits within their breeding program.
Les temps recomposés des beaux-parents : du temps avec au temps pour les beaux-enfants
Authors: Buisson Guillemette , Le Pape Marie-Clémence
Published: April 2024

En France, l’approche statistique conventionnelle met l’accent sur le critère de la résidence principale pour définir le statut de beau-parent. Ce choix invisibilise la situation de nombreuses femmes qui, sans avoir les enfants de leur conjoint à temps plein chez elles, sont pourtant impliquées dans leur prise en charge. En s’appuyant sur l’exploitation de plusieurs enquêtes, cet article interroge ces différences de genre, en analysant les profils de beaux-pères et de belles-mères selon le temps passé dans le même logement avec les beaux-enfants et ce qui est fait durant ce temps partagé (répartition des tâches parentales). Il montre que le temps passé par les enfants au domicile ne correspond pas à un profil social particulier de beaux-pères (à l’exception des cas de résidence alternée) tandis que celui des belles-mères est, a contrario, très fortement distinct selon le temps qu’elles passent avec leurs beaux-enfants. Quand ces derniers sont présents au quotidien, les belles-mères prennent davantage en charge les tâches parentales contraintes tandis que les beaux-pères y sont moins impliqués. La présence des enfants n’a donc pas les mêmes effets pour les beaux-pères et pour les belles-mères, révélant ainsi les inégalités sociales et de genre qui se jouent dans les recompositions familiales.
Repenser l’innovation
Authors: Venne Jean-François
Published: April 2024

Sacrifierons-nous l’avenir de l’humanité sur l’autel du dieu Innovation, convaincus qu’il nous offre les clés de notre salut ? Des penseurs appellent à éviter ce piège en révisant la notion d’innovation et en redonnant une place centrale à l’être humain.
Vers un monde inassurable ?
Authors: Venne Jean-François
Published: April 2024

Les changements climatiques menacent de rendre certaines zones inassurables et contribuent à augmenter le coût des primes d’assurance des citoyens et des entreprises. Seule piste de solution : diminuer les risques en devenant plus résilients.
Jean-François Fortin-Verreault : la gestion, une façon d’être utile
Authors: Auger Claudine , Chauvin Maude
Published: April 2024

À la tête du Centre intégré universitaire de santé et de services sociaux de l’Est-de-l’Île-de-Montréal depuis décembre 2021, Jean-François Fortin-Verreault est l’un des plus jeunes PDG du réseau québécois de la santé. D’ambitieux projets l’attendaient à son arrivée en fonction, notamment le chantier de l’Hôpital Maisonneuve-Rosemont, mais rien ne semble résister à sa volonté de construire.
Ivo Brughmans : le pouvoir du paradoxe
Authors: Barlow Julie
Published: April 2024

Selon le philosophe et consultant en leadership Ivo Brughmans, les vieilles formules du type « il faut couper la poire en deux » pour résoudre des conflits ne tiennent plus la route. Dans son nouveau livre, Paradoxical Leadership: How to Make Complexity an Advantage 1 , l’auteur belge propose de mieux utiliser les tensions vécues dans les entreprises. Elles sont, d’après lui, un outil pour accroître la productivité et l’innovation.
Souffre-t-on d’obésité numérique ?
Authors: Venne Jean-François
Published: April 2024

L’euphorie causée par les possibilités apparemment infinies du virage numérique commence à se heurter à la prise de conscience de son impact environnemental et social. Les entreprises devront apprendre à résoudre ce dilemme.
L’ère numérique pourrait-elle prendre fin plus vite qu’on pense ?
Authors: Venne Jean-François
Published: April 2024

L’essor du domaine numérique semble actuellement irrépressible, mais il pourrait se fracasser sur ses propres limites matérielles. « Raison de plus pour se tourner vers la sobriété numérique », soutient le fondateur de Green IT, Frédéric Bordage.
Le travail hybride, comment l’optimiser ?
Authors: Chabault Denis , Jiollent Jérome
Published: April 2024

Optimiser le travail hybride reste un véritable défi. Bien souvent, les entreprises ont une vision partielle de sa mise en place qui ne leur permet pas d’équilibrer performance et bien-être des employés. Comment faire ?
Accorde-t-on assez d’importance à l’expérience gestionnaire ?
Authors: Bertholet Jean-François , Rousseau Alexandre
Published: April 2024

« Les leaders héroïques sont littéralement capables de galvaniser les troupes » : voilà un mythe tenace qui occulte parfois le fait que les gestionnaires sont avant tout des êtres humains ayant eux aussi des besoins et des préoccupations qui leur sont propres, et qui influent sur leur bien-être comme sur leur performance.
Pour en finir avec les cultures toxiques
Authors: Mathieu Cynthia , Labelle-Deraspe Rémi
Published: April 2024

Bien qu’on en parle de plus en plus, les cultures toxiques restent omniprésentes dans les milieux de travail. Celles-ci se maintiennent au détriment du bien-être des employés et des gestionnaires, en plus d’avoir un effet réel sur l’image que les organisations projettent. Mais quels sont donc les mécanismes qui contribuent à leur maintien, malgré tous les efforts et les investissements mis de l’avant par les entreprises afin de favoriser des milieux de travail sains ?
Innovez autrement, disnovez !, d’Arnaud Groff et Lionel Meneghin
Authors: Jézéquel Myriam
Published: April 2024

Innover d’une manière qui profite à tous et qui préserve la planète, c’est possible. Disnover, c’est innover en se plaçant au service de l’humanité et pas uniquement du marché. Le principe ? Faire entrer les entreprises dans une ère (nouvelle) de « progrès holistique » avant que la planète ne soit à bout de souffle. Réflexion rafraîchissante – et croisée – d’un entrepreneur et d’un philosophe.
Feedback : le pouvoir des conversations, de Stéphane Moriou
Authors: Jézéquel Myriam
Published: April 2024

Soudain, une remarque se glisse dans la conversation, un conseil à la dérobée s’invite à la table, une suggestion est émise. Il existe un « génie » du feedback , affirme l’entrepreneur et conférencier Stéphane Moriou. De quoi est fait ce simple outil de transformation ?
Effects of different reproduction management protocols on the reproduction efficiency of three indigenous Greek sheep breeds
Authors: Symeon George K. , Giantsis Ioannis A. , Avdi Melpomeni
Published: April 2024

The aim of this study was to evaluate the effects of two different methods of controlling ovine reproduction (ram effect and a combination of eco-friendly substances) in three Greek indigenous sheep breeds, namely Florina, Karagouniko, and Chios. 180 ewes, aged 2–3 years old, were used, equally divided between the three Greek sheep breeds. Each breed was divided in two equal experimental groups: In group ECO (combination of eco-friendly substances), a dose of Gonadotropin-releasing hormone (GnRH) was administered at day 0, followed by an intramuscular injection of prostaglandin seven days later and another dose of GnRH at day 9. In group ME, sexually active males were introduced to the females that have been isolated for 3 months. The experiment was conducted in three consecutive years: 2020, 2021, and 2022. Average estrus expression and fecundity in all three examined breeds was comparable, with the exemption of Florina ewes treated with the eco-friendly substances in the first year, a result that could be attributed to the strong seasonal pattern in estrus expression of the Florina breed. The average length to estrus expression in days was significantly lower in the eco-friendly method than the procedure using male effect and the prolificacy was higher for the Chios sheep than the Florina and the Karagouniko breeds. Overall, both methods for the induction and synchronization of estrus (male effect and PGF2a administration) could be used in sheep reproduction with promising results. Nevertheless, the male effect seems to be more efficient in indigenous breeds with long anestrus periods.
Least squares solutions of matrix equation $ AXB = C $ under semi-tensor product
Authors: Wang Jin
Published: April 2024

This paper mainly studies the least-squares solutions of matrix equation $ AXB = C $ under a semi-tensor product. According to the definition of the semi-tensor product, the equation is transformed into an ordinary matrix equation. Then, the least-squares solutions of matrix-vector and matrix equations respectively investigated by applying the derivation of matrix operations. Finally, the specific form of the least-squares solutions is given.
A new approach to Leonardo number sequences with the dual vector and dual angle representation
Authors: Babadağ Faik , Atasoy Ali
Published: April 2024

In this paper, we introduce dual numbers with components including Leonardo number sequences. This novel approach facilitates our understanding of dual numbers and properties of Leonardo sequences. We also investigate fundamental properties and identities associated with Leonardo number sequences, such as Binet's formula and Catalan's, Cassini's and D'ocagne's identities. Furthermore, we also introduce a dual vector with components including Leonardo number sequences and dual angles. This extension not only deepens our understanding of dual numbers, it also highlights the interconnectedness between numerical sequences and geometric concepts. In the future it would be valuable to replicate a similar exploration and development of our findings on dual numbers with Leonardo number sequences.
On Cauchy-type problems with weighted R-L fractional derivatives of a function with respect to another function and comparison theorems
Authors: Othmane Iman Ben , Nisse Lamine , Abdeljawad Thabet
Published: April 2024

The main aim of this paper is to study the Cauchy problem for nonlinear differential equations of fractional order containing the weighted Riemann-Liouville fractional derivative of a function with respect to another function. The equivalence of this problem and a nonlinear Volterra-type integral equation of the second kind have been presented. In addition, the existence and uniqueness of the solution to the considered Cauchy problem are proved using Banach's fixed point theorem and the method of successive approximations. Finally, we obtain a new estimate of the weighted Riemann-Liouville fractional derivative of a function with respect to functions at their extreme points. With the assistance of the estimate obtained, we develop the comparison theorems of fractional differential inequalities, strict as well as nonstrict, involving weighted Riemann-Liouville differential operators of a function with respect to functions of order $ \delta $, $ 0 < \delta < 1 $.
Probabilistic type 2 Bernoulli and Euler polynomials
Authors: Chen Li , Dolgy Dmitry V. , Kim Taekyun , Kim Dae San
Published: April 2024

Assume that the moment-generating function of the random variable $ Y $ exists in a neighborhood of the origin. The aim of this paper is to investigate the probabilistic type 2 Bernoulli polynomials associated with $ Y $ and the probabilistic type 2 Euler polynomials associated with $ Y $, along with the probabilistic type 2 cosine-Bernoulli polynomials associated with $ Y $, the probabilistic type 2 sine-Bernoulli polynomials associated with $ Y $, the probabilistic type 2 cosine-Euler polynomials associated with $ Y $, and the probabilistic type 2 sine-Euler polynomials associated with $ Y $. We deal with their properties, related identities and explicit expressions.
A two-step iteration method for solving vertical nonlinear complementarity problems
Authors: Guo Wenxiu , Lu Xiaoping , Zheng Hua
Published: April 2024

In this paper, for vertical nonlinear complementarity problems, a two-step modulus-based matrix splitting iteration method is established by applying the two-step splitting technique to the modulus-based matrix splitting iteration method. The convergence theorems of the proposed method are given when the number of system matrices is larger than 2. Numerical results show that the convergence rate of the proposed method can be accelerated compared to the existing modulus-based matrix splitting iteration method.
Les collections vestimentaires du musée de Bretagne
Authors: Prod’homme Laurence
Published: April 2024

Les collections textiles du musée de Bretagne (Rennes, Ille-et-Vilaine) sont conséquentes en nombre et ont vocation à représenter l’ensemble des modes portées dans la région, qu’il s’agisse du costume régional ou du vêtement de travail. Elles rassemblent essentiellement des vêtements, mais aussi du linge de maison, des bannières et drapeaux, des échantillons textiles… Leur constitution est révélatrice de l’évolution du musée lui-même, qui au fil du temps a laissé aux collections vestimentaires une place plus conséquente. Les premières décennies du xxe siècle voient arriver des collections d’uniformes et tenues militaires, accompagnées de quelques embryons de pièces vestimentaires régionales. En 1913, une exposition d’ethnographie permet la première présentation de costumes bretons et entraîne une légère dynamique dans ce domaine. Il faut attendre les années 1950-1960 avec l’ouverture de la « galerie des costumes », pour que ces collections, sous le contrôle de René-Yves Creston et Georges Henri Rivière, prennent davantage d’ampleur. Des années 1980 à aujourd’hui, les enrichissements n’ont pas cessé, mais la politique d’acquisition a dès lors tenté d’appréhender le vêtement comme un objet culturel et social au même titre que toutes les collections matérielles. Les collections photographiques du musée, par leur ampleur et leur diversité, servent aussi de pendants et de sources aux collections vestimentaires et permettent de réinterroger la question du vêtement dans la société bretonne.
Un japonisme patrimonial
Authors: Delille Damien
Published: April 2024

L’origine des patrimoines de mode venus du Japon répond à une histoire complexe, associée à la vogue du japonisme en France, durant la seconde moitié du xixe siècle. Cet article analyse les différentes étapes historiques d’intégration dans les collections privées et publiques de ces objets textiles et vestimentaires japonais, à partir des acteurs – marchands, collectionneurs, artistes, scientifiques – qui s’y sont intéressés. La notion de patrimoine vestimentaire et textile au Japon est interrogée dans le contexte d’occidentalisation de l’archipel durant l’ère Meiji entre 1868 et 1912. L’étude du rôle moteur des Expositions universelles, en particulier celle de Vienne en 1873, contribue ensuite à identifier la constitution des premières collections de fukusa, kimonos et autres éléments de l’habit nippon, dont les créations sont antérieures à l’ouverture du pays à l’Occident. À l’orée du xxe siècle, le musée des Arts décoratifs de Paris et le musée des Tissus de Lyon se portent acquéreurs de plusieurs de ces collections, afin de rendre accessibles des pratiques singulières auprès des publics d’amateurs et des industries textiles. L’article explore ce long processus qui permet de faire entrer ces objets vestimentaires non-occidentaux dans l’histoire patrimoniale en France et au Japon.
Le vêtement historique hors des vitrines
Authors: Deschênes Janie
Published: April 2024

Les guides-interprètes costumés sont nombreux dans les sites patrimoniaux et les musées en plein air de l’Est du Canada. Arborant des reproductions de vêtements d’époque, ils sont chargés de répondre aux questions des visiteurs, de les guider à travers les expositions et de leur faire vivre une expérience hors du commun. Ils sont également parfois responsables d’animations théâtrales ou de vulgarisation de métiers anciens. Les habits qu’ils revêtent participent d’une scénographie muséale recherchée mettant en valeur les bâtiments et les artéfacts environnants. Cette démarche permet d’admirer à la lumière du jour et de faire se mouvoir des costumes dont les originaux sont généralement gardés sous vitrine dans les musées. Véritable image de marque de certaines institutions, les costumes portés par les guides-interprètes sont soumis à de nombreuses contraintes techniques et financières qui peuvent menacer ce choix. La difficulté de trouver au Canada des boutiques spécialisées en reconstitution historique, l’augmentation des prix des tissus et la rareté des ateliers de couture génèrent de nombreux défis pour les musées qui souhaitent continuer à costumer leurs employés. La planification d’une politique annuelle de financement, d’actualisation des coupes et d’entretien peut cependant faciliter la gestion d’une garde-robe pour les guides et contribuer au maintien de cet apport intéressant à l’ambiance d’un site patrimonial.
Durability Properties of Engineered Cementitous Composites (ECC)
Authors: Üstündağ Özlem
Published: April 2024

The brittle structure of concrete and the crack formation easily under various chemical and physical effects adversely affect its durability against long-term effects under difficult environmental conditions. Unlike ordinary concrete materials, tight microcrack formation under tensile loads, superior strain hardening behavior, and self-healing properties provide ECC high durability under harsh environmental conditions. These properties also make ECC a unique repair material used to renovate damage to existing structures. This study presents a detailed review of ECC's durability properties under aggressive environmental effects such as shrinkage, freeze-thaw, high temperature, water permeability, sulfate, chloride, sea water, acid, abrasion, and its use as a repair material under these harsh environmental conditions and makes recommendations.
Corrosion Resistance and Permeability Properties of UHPC-ECC
Authors: Athibaranan S. , Jayakumar Karthikayan , Ganesh Prabhu G. , Sridhar J.
Published: April 2024

Ultra high performance engineered cementitious composites (UHP-ECCs) are advanced cementitious materials that exhibit exceptional strength, durability, and ductility. This chapter reviews the corrosion resistance and permeability properties of UHP-ECCs, which are critical factors in determining their suitability for various applications. UHP-ECCs have been shown to exhibit excellent resistance to corrosion in harsh environments due to their high cement content, low water-to-cement ratio, and the incorporation of various fibers. Additionally, UHP-ECCs exhibit extremely low permeability to liquids, gases, and ions, which makes them suitable for a wide range of applications, including water storage, wastewater treatment, and transportation infrastructure. The chapter concludes that UHP-ECCs are a highly desirable material for applications where corrosion resistance and low permeability properties are essential.
Current Investigations and Field Performances of Engineered Cementitious Composites (ECC) in Transportation Infrastructure
Authors: Chandrasekhar Chintada , Ransinchung G. D. R. N.
Published: April 2024

Engineered cementitious composites (ECC) or strain-hardening cement-based composites (SHCC) were initially developed in the early 1990s, and later, many advancements were made in matrix composition. The development of ECC hinged on gaining a comprehensive understanding of how the materials integrated into the matrix performed in in-situ conditions. The field application provides an opportunity to capitalize on ECC's enhanced mechanical properties, particularly the structural performance caused by various loading conditions. This chapter briefly introduces concrete pavement cracking and fiber-reinforced concrete (FRC) classification and then introduces ECC and its mix design characteristics. Later, the developments and applications of ECC in transportation-related infrastructure were introduced. The innovative ideas related to highway or airport pavement with conventional or ultra-thin white topping overlay, field-related construction, and their current performance were discussed in separate sections.
O processo de compartilhamento do conhecimento em cursos de graduação EaD: uma análise da relação inLintra e entre setores
Authors: Calvi Gabriel Coutinho , Rosa Jaqueline Ganassin , Almeida Iara  Carnevale de , Sartori Viviane
Published: April 2024

Cada vez mais, detecta-se a importância de comunicação e compartilhamento adequado das informações entre os diferentes agentes que constroem conteúdos de aprendizagem. Caso contrário, o conhecimento pode chegar de forma fragilizada e/ou segmentada aos discentes, por meio dos diferentes canais, como aulas, material didático, ambiente virtual de aprendizagem, dentre outros. Este estudo tem o objetivo geral de analisar o processo de comunicação intra e entre setores de cursos de graduação na modalidade de Educação a Distância (EaD) de uma Instituição de Ensino Superior (IES) privada no estado do Paraná. A pesquisa é de natureza aplicada com abordagem quantitativa e, para atender aos objetivos propostos, foi aplicado um questionário on-line junto aos colaboradores dos diferentes setores da IES do estudo de caso, com uma posterior análise estatística dos dados coletados e com apoio da ferramenta Google Forms. O resultado da análise é um panorama sobre os processos de comunicação e compartilhamento do conhecimento dessa IES, identificando que os profissionais da tutoria off-line e os outros profissionais (coordenador, tutor pedagógico, tutor on-line e professor formador) devem procurar estar em sinergia durante o fechamento de cada uma das disciplinas, bem como com a efetividade das atividades disponibilizadas para os discentes, a fim de que se possa promover o refinamento contínuo desses materiais.
CONHECIMENTO DE GRADUANDOS DA SAÚDE DA UNIVERSIDADE ESTADUAL DE MARINGÁ SOBRE O IMPACTO DOS ABSORVENTES NO MEIO AMBIENTE
Authors: Laguila Altoé Isadora , Trannin de Mello Sônia
Published: April 2024

Este estudo investigou o conhecimento dos alunos de cursos da saúde da Universidade Estadual de Maringá (UEM) sobre alternativas ecológicas e impacto ambiental dos absorventes. Utilizou-se um questionário online e a análise envolveu abordagens quantitativas e qualitativas. Resultados revelaram que a maioria acha importante discutir menstruação, métodos e descarte de absorventes. Porém, isso contrasta com a falta de inclusão desses tópicos na grade curricular. Mais de 80% dos participantes desconheciam o tempo de decomposição dos absorventes descartáveis. Sobre as opções ecológicas, muitos conheciam essas alternativas. Constatou-se que a maioria ainda usa absorventes descartáveis, embora tenham interesse nos métodos ecológicos. O preço foi importante na compra de absorventes, afetando a renda familiar de alguns participantes. Concluiu-se que os alunos da saúde da UEM têm lacunas no conhecimento do impacto ambiental dos absorventes descartáveis, apesar de estarem cientes das opções ecológicas, o que é promissor, considerando seu futuro na assistência à população.
Exploring the effects of the past civil war in terms of the prevalence and associating factors of PTSD
Authors: Monaragala R. M. M.
Published: April 2024

The Sri Lanka Army experienced a civil war, which ended in 2009. PTSD is a chronic psychological complication following trauma associated with war, and this study intends to explore the extent of PTSD ten years after the civil war in the Army.Aims:This study aimed at describing the prevalence of PTSD and its associated factors among armed personnel with combat experience.Methods: This was a cross-sectional study, conducted in 2019, in the East of Sri Lanka with a total sample of 3365. The other ranks were selected from 71 clusters by multi-stage cluster sampling method whilst the officers were selected by systematic random sampling method from the Officers’ Seniority List. The locally validated PTSD checklist military version (PCL-M) questionnaire was used to screen PTSD. A standard questionnaire was used to obtain data on sociodemographics, aggression, smoking, and cannabis usage, whereas locally validated tools (PHQ-9, Chalder fatigue scale, and AUDIT) were used to gather information on psycho-logical and behavioral factors. Data were analyzed with SPSS-20, and the significance of factors associated with PTSD (p≤0.05) was determined by the Chi-Square test. Multiple logistic regression was used to exclude confounders. The study was conducted after the ethical clearance from the Ethical Review Committee of the Faculty of Medicine, KDU.Results: Of the sample, 1845 (75 officers and 1772 other ranks) had combat exposure and were chosen for this study.  The prevalence of PTSD was 3.9%. Battle events and consequences, probable depression, fatigue, high-risk drinking (HRD), childhood abuse, expression of aggression, psychiatric family history, inward admission, absenteeism, and psychosocial dysfunction were significantly associated with PTSD. After adjusting the odds ratios, probable depression, fatigue, aggression, and family history of mental disorder, were predictive of PTSD.Conclusions: Even after ten years, the psychological effect of the civil war persists. Early exposure to childhood abuse, psychiatric family history, and younger age at combat exposure could be risk factors for PTSD, and HRD, depression, fatigue, psychosocial dys-function, absenteeism, aggression, and tendency to seek medical treatment can be outcomes of PTSD. Screening and psychosocial intervention are recommended in the field.
Towards the same goal from different ends: the use of arts in psychiatric practice
Authors: Liyanage N.
Published: April 2024

Various artistic modalities are used as an alternative or supplementary treatment method in modern-day psychiatric practice. It has been shown that artistic activities are beneficial to patients as they provide a platform to open up and share the experiences, feelings, perceptions, views, and expectations of their lives with mental illnesses. Artistic activities can be used as a powerful tool to improve empathy not only in clinicians but also in patients by allowing them to view the world from a different perspective. Artistic modalities can be effectively used in mental health promotion and prevention when adopted by cultures. The ultimate goal of biologically driven psychiatric practice is to reduce the suffering due to mental illnesses, and the incorporation of non-pharma-cological treatment modalities like artistic activities can complement achieving the same target.
Complete Genomic Assembly of Mauritian Cynomolgus Macaque Killer Ig-like Receptor and Natural Killer Group 2 Haplotypes
Authors: Prall Trent M , Karl Julie A , Varghese Joshua M , Baker David A , Minor Nicholas R , Raveendran Muthuswamy , Harris R Alan , Rogers Jeffery , Wiseman Roger W , O’Connor David H
Published: April 2024

Mauritian-origin cynomolgus macaques (MCMs) serve as a powerful nonhuman primate model in biomedical research due to their unique genetic homogeneity, which simplifies experimental designs. Despite their extensive use, a comprehensive understanding of crucial immune-regulating gene families, particularly killer Ig-like receptors (KIR) and NK group 2 (NKG2), has been hindered by the lack of detailed genomic reference assemblies. In this study, we employ advanced long-read sequencing techniques to completely assemble eight KIR and seven NKG2 genomic haplotypes, providing an extensive insight into the structural and allelic diversity of these immunoregulatory gene clusters. Leveraging these genomic resources, we prototype a strategy for genotyping KIR and NKG2 using short-read, whole-exome capture data, illustrating the potential for cost-effective multilocus genotyping at colony scale. These results mark a significant enhancement for biomedical research in MCMs and underscore the feasibility of broad-scale genetic investigations.
Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways
Authors: Hussein Ramadan S , Eyada Moustafa M , Mostafa Rashad M , Elaidy Samah M , Elsayed Shereen H , Saad Hany M
Published: April 2024

Thyroid hormones play essential roles in spermatogenesis, but their effects on infertile males remain poorly understood. This study aimed to evaluate the impact of combining carbimazole (CBZ) with vitamin E (VE) on testicular injury induced by experimental hyperthyroidism in adult albino rats, focusing on oxidative, inflammatory, and apoptotic pathways. In this experimental study, 64 adult male albino Wistar rats were divided into eight groups: Group I (control-untreated), Group II (CBZ-control), Group III (VE-control), Group IV (CBZ + VE-control), Group V (levothyroxine-induced testicular injury), Group VI (levothyroxine + CBZ-treated), Group VII (levothyroxine + VE-treated), and Group VIII (levothyroxine + CBZ + VE-treated). The study was conducted in the Faculty of Medicine, Suez Canal University (Ismailia, Egypt). After cervical decapitation, both testes and epididymis were examined histopathologically and immunohistochemically. Significant differences were observed among groups concerning malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT; all P < 0.001). Polymerase chain reaction analysis showed significant differences in tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), Bcl-2-associated X protein (BAX), B-cell lymphoma 2 protein (Bcl2), p53, Caspase-3, Caspase-8, Caspase-9, and nuclear factor-kappa B (NF-κB) mRNA levels (all P < 0.001). Hyperthyroid group treated with CBZ alone (Group VI) exhibited testicular side effects, affecting seminiferous tubules and spermatogenesis. However, the Group VIII showed improved spermatogenesis and a decrease in testicular side effects. The addition of VE to the treatment of hyperthyroid rats with CBZ reduced testicular side effects and seminiferous tubular affection when potentially improving spermatogenesis. Further research is needed to elucidate the underlying mechanisms fully.
Male reproductive function before and after the adjustment of the COVID-19 prevention policy: a multicenter study in China
Authors: Li Jian-Zheng , Wu Han , Wang Li , Wang Yun-Shan , Kong Feng , Cao Long-Qiao , Liang Ming , Wang Xiong , Yuan Ming-Zhen
Published: April 2024

At the end of 2022, the adjustment of the coronavirus disease 2019 (COVID-19) pandemic control policy in China resulted in a large-scale increase in public infection. To compare the fertility parameters of male patients before and after the adjustments of the COVID-19 pandemic control policy in China, we collected data on patients’ medical histories and laboratory examinations on their first visits between June 2022 and March 2023 in five different hospitals. Data were divided into five groups according to the timeline of the policy adjustment. The data we collected from male patients included semen quality and serum reproductive hormone levels, and intergroup comparisons were made using the Mann–Whitney U and Chi-square tests. In total, 16 784 cases underwent regular semen analysis, 11 180 had sperm morphology assessments, and 7200 had reproductive hormone analyses. The data showed declining trends in semen volume, sperm motility, and the progressive sperm motility rate after the policy adjustment. Subgroup comparison revealed an initial decrease and gradual recovery in progressive motility rate. Sperm morphology analysis showed increased neck and tail abnormalities after the policy adjustment. No significant change in hormone levels was observed. Following the adjustment of the COVID-19 prevention policy in China, a decline in sperm motility and morphology was observed. This trend may gradually recover over 2 months. After the policy adjustment, reproductive hormone levels were relatively stable throughout, except for an increase in luteinizing hormone (LH). These changes in semen parameters suggest that the policy adjustment had a short- to medium-term impact on male reproductive function.
Orchiopexy: one procedure, two diagnoses – different male infertility outcomes
Authors: Newman Nitza Heiman , Farber Idan , Lunenfeld Eitan , Zeadna Atif , Vardi Iris Har , Assi Zaki
Published: April 2024

Infertility, affecting one in six couples, is often related to the male partner’s congenital and/or environmental conditions or complications postsurgery. This retrospective study examines the link between orchiopexy for undescended testicles (UDT) and testicular torsion (TT) in childhood and adult fertility as assessed through sperm analysis. The study involved the analysis of semen samples from 7743 patients collected at Soroka University Medical Center (Beer Sheva, Israel) between January 2009 and December 2017. Patients were classified into two groups based on sperm concentration: those with concentrations below 5 × 106sperm per ml (AS group) and those above (MN group). Medical records and surgical histories were reviewed, categorizing orchiopexies by surgical approach. Among 140 individuals who had undergone pediatric surgery, 83 (59.3%) were placed in the MN group and 57 (40.7%) in the AS group. A higher likelihood of being in the MN group was observed in Jewish compared to Arab patients (75.9% vs 24.1%,P= 0.006). In cases of childhood UDT, 45 (78.9%) patients exhibited sperm concentrations below 5 × 106sperm per ml (P< 0.001), and 66 (76.7%) had undergone unilateral and 18 (20.9%) bilateral orchiopexy. Bilateral orchiopexy was significantly associated with lower sperm concentration, total motility, and progressive motility than unilateral cases (P= 0.014,P= 0.001, andP= 0.031, respectively). Multivariate analysis identified UDT as a weak risk factor for low sperm concentration (odds ratio [OR]: 2.712,P= 0.078), with bilateral UDT further increasing this risk (OR: 6.314,P= 0.012). Jewish ethnicity and TT diagnosis were associated with a reduced risk of sperm concentrations below 5 × 106sperm per ml. The findings indicate that initial diagnosis, surgical approach, and ethnicity markedly influence male fertility outcomes following pediatric orchiopexy.
Anaesthetic Challenges in a Child with Noma (Necrotising Ulcerative Stomatitis) for Abbe Flap Reconstructive Surgery
Authors: Patil Shruti , Kawale Netraj , Shashidhar Kshithija , Parikh Devangi
Published: April 2024

Noma, also known as necrotising ulcerative stomatitis, gangrenous stomatitis or cancrum oris is an orofacial gangrene. It is usually seen in children of developing countries, between the age group of 2 and 7 years, who are malnourished and debilitated by disease. We present a case of a 7-year-old child posted for Abbe flap reconstruction followed by division. We have discussed the airway challenges in this case and suggest a tailored approach as per the patient’s requirement, the anaesthesiologist’s skills and the equipment available.
Outcome and late effects of matched related peripheral-blood stem-cell transplantation in children with severe aplastic anemia
Authors: Mohamed Wafaa EI , Monaem Mowafy Nadia MA , Talkhan Hala AS , Sayed Safa M , Ali AbdelZaher Alaa TM
Published: April 2024

Background

Aplastic Anemia (AA) is a life- threatening disease. Cure can be achieved in a large proportion of patients with prompt treatment with matched sibling donor Hematopoietic Stem Cell Transplantation (HSCT) as first line therapy.

Aim

Study of the outcomes and late effects among children with severe aplastic anemia after receiving matched related peripheral-blood stem-cell (PBSC) transplantation and cyclophosphamide/antithymocyte globulin conditioning regimen at Ain Shams University Pediatric Bone Marrow Transplantation Unit, Cairo, Egypt.

Methods

Data of 15 patients with severe aplastic anemia who received matched related PBSC transplantation between January 2011 and December 2018 were analysed retrospectively. All long-term survivors were followed up for 2 years. Follow up studies included detailed assessment of growth, graft evaluation, immune reconstitution, long-term effects on the liver, kidney, pulmonary, cardiac, endocrine functions, chronic graft-versus-host disease (GVHD), and infectious complications.

Results

The median duration of the study was 87 months (43–115 months). The overall survival was 73.3%. Event-free survival was 66.7%. All mortality was within 2 months posttransplant. Blood counts were within normal limits. Chimerism was complete for all except one. Growth assessment revealed Z score of weight, height, and BMI 0 (−1.8–1.6), −0.7 (−1.8–0.95), and 0.34 (−1.29–2). Abnormal thyroid function was found in three (27%) patients. No documented high-grade acute GVHD or extensive chronic GVHD. Cardiac, pulmonary, hepatic, and renal functions showed no abnormality. Immune reconstitution was consistent, and no malignant complications were reported.

Conclusion

This study confirmed the feasibility and safety of matched related PBSC transplantation in the pediatric population in low-income countries. Overall survival and event-free survival were satisfactory.
A T-cell receptor as a promising immunotherapeutic target in acute myeloid leukemia: expression of T cell immunoglobulin and mucin-containing-3 on bone marrow hematopoietic cells
Authors: Atif Heba M , Eid Inas A M
Published: April 2024

Background

The emergence of immunotherapy has changed the treatment landscape of various types of cancers. However, limited target antigen remains to be a challenge for its application in acute myeloid leukemia (AML). T cell immunoglobulin and mucin-containing-3 (Tim-3) is an immune checkpoint receptor that plays a major role in the escape of host immune surveillance in AML. Thus, its role in cancer treatment needs to be thoroughly investigated.

Methods

Tim-3 expression on blasts, lymphocytes, and monocytes was analyzed by flow cytometry in bone marrow samples of 60 newly diagnosed AML patients and 30 matched non-neoplastic controls. Its association with different prognostic clinicopathological parameters was also evaluated. ROC curve confirmed the value of Tim-3 expression in discriminating AML patients from healthy controls and the role of Tim-3 in disease aggressiveness was also investigated.

Results

The median percentage of myeloblasts positive for Tim-3% and MFI were significantly higher in AML than normal controls (64.27% and 1.34 in patients vs. 41.89% and 1.12 in controls) and it was markedly associated with poor overall survival of the patients. Besides, the upregulation of Tim-3 on AML blasts was significantly higher than on lymphocytes and monocytes in denovo AML patients (P <0.001).

Conclusion

This study indicates Tim-3 as a poor prognostic marker in AML and highlights Tim-3 as a new therapeutic target antigen for immunotherapy with low off-target toxicity.
Prevalence of anti-glycoprotein V in patients with primary immune thrombocytopenia
Authors: Azzazi Mohamed O , Nabeeh Nermeen A , Mohamed Asmaa M , Abdelfatah Rana G
Published: April 2024

Background

Glycoprotein (GP) V is a well-characterized immune target in Varicella-associated and drug-induced thrombocytopenia. Recent studies have focused on the involvement of anti-GP V in the mechanism of platelet clearance as a recent paradigm in the pathophysiology of immune thrombocytopenia (ITP), rather than other anti-GPs like GP IIb/IIIa, GP Ib/IX and less frequently GP Ia/IIa.

Objectives

This study was conducted to determine the prevalence of anti-GP V in adult ITP Egyptian patients and to detect its impact on the outcome in these patients.

Patients and methods

This was a cross-sectional study in which, using enzyme-linked immunosorbent assay, the level of serum anti-GP antibodies V was measured in the peripheral blood of 90 patients with primary ITP compared with 20 age-matched and sex-matched normal healthy controls and its relationship with clinical, laboratory parameters, and response to treatment.

Results

Our study revealed that anti-GP antibodies V level in the cases group was statistically significantly higher as compared with the control group (P=0.005). There was weak statistically significant positive correlation between platelet count and anti-GP V level antibodies in the cases group after treatment with a P value of 0.0548. However, the level of anti-GP V did not show significant correlation with the bleeding score (P=0.123), degree of thrombocytopenia (P=0.967), sex (P=0.067), bone marrow findings (P=0.448), spleen size (P=0.992), or with the response to steroid therapy (P=0.171).

Conclusion

This study points out that GP V is a frequent immune target in ITP and that the detection of GP-specific autoantibodies being of value in the pathogenesis of ITP. We recommend that further studies including GP V are required before ITP treatment can be tailored according to platelet autoantibody specificity.