bluuebunny/crossref_metadata_2025 huggingface dataset:
Ks. Adolf Józef Bożeniec Jełowicki (1863-1937) – pierwszy Polak w jerozolimskiej szkole biblijnej
Authors: Marczewski Jarosław Roman
Published: January 2020

The aim of this paper is to discuss and answer for the first time the question of the earliest Polish presence at the École biblique et archéologique française de Jérusalem. As an outcome of archival research carried out at St. Stephan’s Convent in Jerusalem following conclusions can be drawn. First of all, the attendance of Poles at the École biblique dates back to the very beginning of the school. As early as in 1892 that is only two years after its first commencement a Polish priest from the Archdiocese of Warsaw, Rev. Adolf Józef Bożeniec Jełowicki started his biblical studies there. He had an occasion to meet in person the founder of the school and the famous professor Fr. Marie-Joseph Lagrange. Rev. Jełowicki was also a witness to the creation of the important periodical “Revue Biblique”. Lectures at that time were few, and in the process of studying, the emphasis was put not only on theoretical knowledge, but also on discovering the Holy Land through practical classes in archeology and topography. Lastly, the stay of Rev. Jełowicki at the École biblique was only one year long nevertheless it resulted in the publication of a professional guide to Jerusalem and its surroundings, as well as several dozen encyclopedic entries on biblical topics. However, after returning to the homeland, Jełowicki could not pursue an academic career path, but the lessons learned at the École biblique became his important asset to future pastoral challenges as a rector in Warsaw, and then as an auxiliary bishop in Lublin.
Trends in development of technologies at hospitality business in the conditions of economy digitalization
Authors: Voronova O. V. , Khareva V. A.
Published: January 2020

This article discusses trends in development of technologies at hospitality business in the conditions of economy digitalization. At the current time economy digitalization of the Russian Federation significantly affects hospitality industry, in particular, hotel automation associated with the use of modern technologies that improves the quality of customer service. This research focuses on such technologies as artificial intelligence, blockchain, augmented reality technologies, cloud technologies, analysis of speech scripts, face recognition technologies, voice assistants, and many others.

The results of the study show that despite the fact that hotel business is successfully mastering modern digital technologies, only fulfillment of continuous data collection, processing, analysis and aggregation will allow the hospitality industry management to achieve one of their main goals, which is to better understand their customers and interact with them.
Multiple scattering camouflaged as magnetic stripes in single crystals of superconducting (La,Sr)2CuO4
Authors: Ţuţueanu Ana E. , Tejsner Tim B. , Lǎcǎtuşu Monica E. , Hansen Henriette W. , Eliasen Kira L. , Böhm Martin , Steffens Paul , Niedermayer Christof , Lefmann Kim
Published: January 2020

Neutron diffraction has been a very prominent tool to investigate high-temperature superconductors, in particular through the discovery of an incommensurate magnetic signal known as stripes. We here report the findings of a neutron diffraction experiment on the superconductor (La,Sr)2CuO4, where a spurious signal appeared to be magnetic stripes. The signal strength was found to be strongly dependent on the neutron energy, peaking at [Formula: see text]. We therefore attribute the origin of this signal to be a combination of multiple scattering and crystal twinning. A forward calculation of the scattering intensity including these two effects almost completely recovers our experimental observations. We emphasize the need for employing such analysis when searching for ways to avoid spurious scattering signals.
IMPLEMENTASI MODEL SUPERVISI BERBASIS KEIKHLASAN DALAM PENINGKATAN KINERJA GURU PAI DI SMP NEGERI KABUPATEN NAGAN RAYA
Authors: Herman Herman , Idris Jamaluddin
Published: January 2020

The sincerity-based supervision model is one of the supervision models in promoting the values of sincerity as the first principle in the workplace, building identity in performing and taking actions, and becoming moral force for PAI supervisors when performing the main tasks and functions. However, the problem that most likely to arise in supervising tasks is the lack of sincerity of PAI supervisor when guiding, developing, and improving the performance of PAI teachers. This study uses a "descriptive" method, by discussing qualitative and inductive thought patterns of events, phenomena or natural phenomena encountered in the field. Data collection instruments were carried out through observation, interviews, and documentation studies. Furthermore, data analysis techniques will be based on the opinion of Miles and Huberman employing data reduction, data presentation, and concluding. Whereas checking the validity of the data is done through source triangulation, method triangulation, and theory triangulation. The results showed that the PAI supervisor had applied the value of sincerity when performing supervisory task for the PAI teacher through a model that was afraid of praise and fame that potentially  cause slander, regarding himself as inferior in the eyes of Him, performing acts of charity quietly and model of non-profit-seeking at work, and type of person who respect at others who surpass themselves. While due to the failure to uphold the values of sincerity at work, the sincerity-based supervision model performed by PAI supervisors, in terms of the effectiveness, has not shown optimal  results in improving the performance of PAI teachers.
Epidemiology of Pediatric Brain Tumor in the Center of Referral Hospital in North Sumatera from 2013 -2017
Authors: Putra Prawira , Tala Ihsan Z , Dharmajaya Ridha , Mouza Abdurrahman , Tandean Steven
Published: January 2020

Brain tumors are the most common disease group of solid tumors in childhood, and children with brain tumors have a relatively poor survival rate. Epidemiologic data from a hospital-based registry provide the necessary information to obtain a full picture of the frequency of this disease, which is a great challenge in pediatric oncology. One hundred thirty four tumors in children between 0 and 17 years of age diagnosed between 2013 to 2017 were classified according the sex, and topography. Incidence of brain tumor in boys were higher than girls. From the registry data, the prevalence for boys was higher (67%). In the whole series, 54% were supratentorial, 46% infratentorial. The most common histopathologic pattern seen in the registry were pilocytic astrocytoma which accounts for 42 cases (31%) followed by medulloblastoma and craniopharygioma with the percentage of 25% and 18% respectively. The least histopathologic pattern of pediatric tumor seen in our center are diffuse astrocytoma and choroid plexus papiloma which was only seen in 1 patient for the last 5 years of our experience.
Medulloblastoma: Intraventricular Recurrences
Authors: Hendy Setiawan  , Celia  , Ridha Dharmajaya
Published: January 2020

Medulloblastoma is the most common malignant pediatric brain tumor. Incidence in adult population is less than 1 %. Medulloblastoma in adult usually between 20 and 40 years old, which is lateral hemispheric and not midline vermian. Survival rate in adult is 67% lower than adolescents is 69% and children is 72%. Location of recurrences most commonly presents at posterior fossa, spinal, supratentorial, and bone metastases. Recurrences of medulloblastoma in supratentorial ventricular is uncommon. The outcome for patients with recurrent medulloblastoma has historically been poor. 37 years old male who presented with severe headache gradually. Patient has history of headache 2 months ago and gait ataxia 1,5 months ago. Patient had surgery 2 years ago with result of hystopathology medulloblastoma. He had irradiation completely 22 months ago. Physical examination showed GCS 15 with gait ataxia. Head CT scan show multiple isodense lesion intraventricular. Before patient had surgery, Head CT scan showed hiperdense lesion at cerebellopontine angle. Seeding medulloblastoma to intraventricular is recurrences which have poor prognosis. Patient had poor condition in few days. Patient died before got reriradiation
Penetrating Brain Injury in Children
Authors: Ula Mutammamin , Dharmajaya Ridha
Published: January 2020

Background: Accidental penetrating brain injury through supraorbital route is an unusual occurrence in emergency practice of civilian cases. At time, it could be potentially life threatening. We report an interesting case of supraorbital penetrating brain injury with an iron stick in a 12-year-old female patient. The stick was removed successfully through supraorbital exploration, without any neurovascular complications.

Case Report: A 12-year-old female presented to our emergency department with injury to his right eye. History revealed that she was practicing marching band in her school as the leader. As she thrown the iron stick, she lost balance and that iron stick entered into her right supraorbital. Her Glasgow Coma Scale (GCS) score, on admission, was 15. There was circumferential laceration on the right supraorbital, flat margins, visible iron stick penetration with diameter 3 cm but no active bleeding was found. Rest of the physical and neurological examination findings were within normal limits. He was resuscitated promptly according to the advanced trauma life support system.

Discussion: Intravenous fluids are given and efforts are taken to maintain high blood oxygen levels.Management of patients with transorbital brain injuries and foreign bodies in situ should follow basic surgical principles, including removal of the object under direct vision in order to reduce further brain tissue damage by the foreign bodies catching on bone fragments. Following removal of the foreign body, thorough debridement with removal of all involved skull bone and foreign materials, hematoma evacuation followed by careful hemostasis along the trajectory, and meticulous dural closure to reduce the possibility of CSF fistula are mandatory.  A transorbital or transcranial approach can be chosen depending on the location of the fragment.

Conclusion: In conclusion, supraorbital penetrating brain injury caused by an iron stick is a rare but fatal event. High index of suspicion toward the presence of foreign bodies and emergent surgical intervention is to be considered in spite of consistent lack of evidence on CT scan. Retrieval should be performed on the operating table under direct vision only after preoperative imaging of neurovascular structures.

Keyword: Penetrating brain injury, Iron Stick
Od Piotrusia Pana do Tajemnic motyli. Stefania Szuchowa, Zofia Rogoszówna, James Matthew Barrie i inni – historia (prawie) rodzinna
Authors: Wieczorkiewicz Aleksandra
Published: January 2020

Celem artykułu jest przeprowadzenie analizy komparatystycznej pokrewieństw tekstowych łączących debiutancki utwór polskiej pisarki Stefanii Szuchowej zatytułowany Tajemnice motyli (1920) z opowieścią Jamesa Matthew Barriego Peter Pan in Kensington Gardens [Piotruś Pan w Ogrodach Kensingtońskich] (1906), która w literaturze polskiej zaistniała po raz pierwszy w roku 1913 dzięki przekładowi Zofii Rogoszówny jako Przygody Piotrusia Pana. Istotnym kontekstem, który towarzyszy prowadzonym przez autorkę tekstu dociekaniom, jest również niemal nieznana biografia Szuchowej, pisarki debiutującej w dwudziestoleciu międzywojennym, będącym w Polsce szczególnie intensywnym okresem w rozwoju oryginalnej oraz przekładowej twórczości literackiej dla dzieci. Analizę filiacji tekstowych między utworami Szuchowej i Barriego uzupełnia studium porównawcze niezwykłych podobieństw ilustracji Stefana Norblina, które towarzyszą pierwszemu wydaniu Tajemnic motyli, do grafik Arthura Rackhama z książki Peter Pan in Kensington Gardens.
Widokówka z Paryża. O polskich przekładach Madeline Ludwiga Bemelmansa
Authors: Olech Karolina
Published: January 2020

Artykuł dotyczy jedynych dotychczasowych przekładów Madeline (1939) Ludwiga Bemelmansa na język polski, które zostają zaprezentowane na tle rozważań o bio­grafii i pozostałej twórczości pisarza. Tłumaczenia wykonane przez Zofię Kierszys (1998) i Małgorzatę Pietrzyk (2015) pozwalają polskiemu czytelnikowi zapoznać się z twórczością anglojęzycznego autora literatury dziecięcej. Autorka tekstu do­wodzi, że różne strategie obrane przez dwie tłumaczki mogą wpływać na odbiór picturebooka, który w Polsce pojawił się prawie sześćdziesiąt lat po amerykań­skiej premierze. Zestawiając ze sobą oryginał i polskie przekłady dzieła, ukazuje również na konkretnym przykładzie ewolucję norm tłumaczeniowych i tendencji translatorskich.
Mujer de 63 años portadora de prótesis de cadera con astenia, cefaleas e hipotiroidismo
Authors: Salvador-Marín Jorge , Ferrández-Martínez Francisco Javier , Gutiérrez-Pastor Aarón , Martínez-López José Fernando , Seguí-Ripoll José Miguel
Published: January 2020

Los pacientes intervenidos de artroplastia de cadera a los que se implanta una prótesis con par de fricción metal-metal pueden desarrollar patologías locales o sistémicas relacionadas con la liberación de partículas de cobalto y cromo como consecuencia del roce continuo de sus superficies metálicas, fenómeno denominado metalosis. Conocer las patologías producidas por esta metalosis es fundamental para, tras su sospecha, solicitar una determinación sérica de cobalto y cromo que confirme el diagnóstico. El tratamiento de la metalosis sintomática consiste en la retirada y sustitución protésica, consiguiendo un descenso en las concentraciones sanguíneas de cobalto, y mejorando el cuadro clínico sistémico. Se presenta el caso de una mujer portadora de prótesis de cadera evaluada en Medicina Interna por presentar de forma crónica astenia, cefaleas, alteraciones sensitivas (vista, oído) e hipotiroidismo.
Kebijakan Redaksi Media dalam Pemberitaan Kehumasan (Analyzing Editorial Policy in Public Relations Release)
Authors: Virajati Cakra , Setianto Widodo Agus
Published: January 2020

Media relations merupakan salah satu fungsi kehumasan yang dilaksanakan dengan menjalin hubungan dengan media melalui produk berita kehumasan.  Kebijakan redaksi terkait hal tersebut menarik untuk dikaji mengingat berita kehumasan berbeda karakteristiknya dengan produk berita lainnya. Penelitian dengan metode studi kasus ini berfokus pada kebijakan redaksi di Harian Jogja dan Kedaulatan Rakyat. Hasil penelitian menunjukkan redaksi menganggap public relations sebagai mitra dan sumber berita dengan menjunjung tinggi etika jurnalistik dan profesionalisme. Latar belakang wartawan, isu yang dipilih redaksi dan tujuan dari masing-masing media, nilai berita, iklan, pembaca, pangsa pasar serta lokalitas konten menjadi faktor dalam menentukan kebijakan redaksi. Pemuatan produk berita kehumasan dilakukan melalui proses gatekeeping berupa penyeleksian, penulisan, penyuntingan, penempatan posisi berita, penjadwalan dan pengulangan.
Archaeology as the meaning of life (in the memory of Leonid Matskevyj)
Authors: Panakhyd Halyna
Published: January 2020

The article is dedicated to the memory of Leonid Matskevyj – Ukrainian archaeologist who studied Palaeolithic and Mesolithic period. Main epochs of his life were highlighted and major publications were listed.
Kolaborasi Antara Pt Gas Negara Dengan Pemerintah Kota Yogyakarta Dalam Mewujudkan Smart City
Authors: Kurniasari Lenny , Purnomo Eko Priyo , Salsabila Lubna
Published: January 2020

This study aims to describe the form of collaborative governance between the Government of Yogyakarta City and the business sector, namely PT Gas Negara in realizing smart cities. The focus of this research is to describe the process of cooperation between the two parties (Government and Private) so that a memorandum of understanding is created to support smart city. This study uses the cross-sector collaboration theory of John M Bryson and Barbara C. Crosby who mentioned collaborative governance must pay attention to the process. This study uses a qualitative patterned research method, while the data from this study are obtained through participant observation, in-depth interviews, document analysis, media and literature. Data in this study were analyzed using data triangulation techniques. Following are some of the findings from this study. First, PT Perusahaan Gas Negara Tbk signed a memorandum of understanding with the Yogyakarta City Government in supporting the smart city program by providing infrastructure and utilizing natural gas as an alternative energy source. Second, PT PGN developed the PGN 360 Degree Integrated Solution service as a follow-up to the provision of electronic-based services and thirdly, the Yogyakarta City Government utilized the ICT services / provider of optical fiber networks owned by PT PGN as a support for smart cities.
Pengembangan Perangkat Pembelajaran Matematika dengan Menggunakan Model Pembelajaran Berbasis Masalah
Authors: Anwar Zakiyah , Ruslan Ruslan
Published: January 2020

Penelitian ini adalah penelitian pengembangan dengan ujicoba terbatas yang bertujuan untuk mengembangkan perangkat pembelajaran dengan Penerapan model pembelajaran berbasis masalah pada pokok bahasan Sistem Persamaan Linear dan Kuadrat yang terdiri dari Buku Siswa, Lembar Kegiatan Siswa, dan Rencana Pelaksanaan Pembelajaran. Subjek Penelitian ini adalah siswa SMA Al Amin Kota Sorong. Prosedur pengembangan yang digunakan dalam penelitian ini adalah model Thiagarajan atau model 4D (Define, Design, Develop, dan Disseminate) yang meliputi empat tahap, yaitu tahap pembatasan, tahap perancangan, tahap pengembangan, dan tahap penyebaran. Hasil dari Validasi instrument dari dua validator menunjukkan perangkat pembelajaran memiliki derajat validitas dan layak untuk di gunakan. Hasil uji coba terbatas perangkat pembelajaran dengan menggunakan model pembelajaran berbasis masalah efektif dan praktis dengan perolehan skor rata-rata hasil tes belajar siswa adalah 82,17 dari skor ideal 100 dengan standar deviasi 10,34. dengan perangkat pembelajaran dengan penerapan model pembelajaran berbasis masalah, siswa jadi lebih aktif dalam proses pembelajaran; pada umumnya siswa memberikan respon yang positif terhadap perangkat pembelajaran, tingkat kemampuan guru dalam mengelola proses pembelajaran dengan menggunakan model pembelajaran berbasis masalah termasuk dalam kategori tinggi, artinya penampilan guru dapat dipertahankan. Penelitian ini sangat penting untuk terus dikembangkan agar dalam pembelajaran di kelas siswa dapat belajar lebih aktif dan efektif.
Delik Penganiayaan Terhadap Anak di Kota Makassar
Authors: Hidaya Wahab Aznul
Published: January 2020

Suatu perlakuan yang dianggap sebagai suatu tindakan yang semena-mena ialah tindak kejahatan terhadap orang. Pada dasarnya kejahatan adalah suatu perbuatan yang merugikan kepentingan umum dan pelakunya dapat dikenakan pidana. Yang mana salah satunya adalah tindak Penganiayaan. Baik yang dilakukan terhadap diri sendiri maupun terhadap orang lain. Beberapa perbuatan atau tindakan-tindakan yang melanggar hukum dan mengganggu keserasian hidup bersama, salah satunya adalah penganiayaan terhadap anak yang mana hampir setiap hari banyak diberitakan di media massa maupun elektronik lainnya. Kasus-kasus penganiayaan sebagaimana kita jumpai dalam kehidupan sehari-hari, merupakan fenomena tersendiri, mengingat dimana seseorang adalah individu yang memiliki emosi yang masih sangat stabil, maka penanganan kasus penganiayaan terhadap anak perlu mendapat perhatian khusus, dimulai dari Hukum acara pidana yang berlaku dalam masyarakat.
Rechtspositie Badan Hukum Privat Dalam Penyelenggaraan Pemerintahan
Authors: R.S. Rakia A. Sakti
Published: January 2020

Penelitian ini bertujuan untuk menganalisis mengenai kedudukan hukum (rechtspositie) badan hukum privat dalam dalam ketatanegaraan, serta kedudukan badan hukum privat dalam penyelenggaraan pemerintahan. Tipe penelitian yang digunakan adalah penelitian hukum normatif-yuridis, yakni mengacu pada norma hukum peraturan perundang-undangan (statute approach), serta teori dan asas hukum sebagai pendukung. Penelitian ini bersifat deskriptif-analitis, dengan pendekatan kualitatif. Hasil penelitian menunjukan bahwa terdapat perbedaan secara paradigmatik antara kajian ketatanegaraan serta administrasi negara, dan kajian keperdataan mengenai konsep badan hukum. Dalam pada itu, praktik sehari-hari menunjukan bahwa badan hukum privat juga terlibat dalam proses penyelenggaraan pemerintahan, walaupun dengan batasan kewenangan tertentu (quasi). Walaupun demikian, diperlukan kajian mendasar sebab negara dalam pengertian staat in beweging memiliki ruang lingkup yang sangat luas. Hal ini dimaksudkan agar hak menguasai negara berdasarkan Pasal 33 ayat (2) dan (3) UUD NRI 1945, tidak bersifat koorporatis semata, sebab menyangkut hajat hidup orang banyak. Pembentukan peraturan perundang-undangan yang mengatur tentang badan hukum secara tersendiri merupakan salah satu opsi konstitusional.Hukum Tata negara, Hukum Administrasi Negara, Badan Hukum.
Pemetaan Kualitas Air Sumur Bor Warga Kota Sorong
Authors: Afdaliah Nur , Pristianto Hendrik
Published: January 2020

Air merupakan kebutuhan dasar bagi kehidupan khususnya bagi manusia yang selama hidupnya selalu memerlukan air, namun demikian air dapat menjadi malapetaka bilamana tidak tersedia dalam kondisi yang benar. Kualitas air menyatakan tingkat kesesuaian air terhadap penggunaan tertentu dalam memenuhi kebutuhan hidup manusia, mulai dari air untuk memenuhi kebutuhan langsung seperti minum dan kebutuhan sehari-hari lainnya, air irigasi atau pertanian, peternakan, perikanan, rekreasi dan transportasi. Kualitas air dapat diketahui dengan melakukan pengujian tertentu terhadap air tersebut. Pengujian yang biasa dilakukan adalah uji kimia, dan fisika. Pada penelitian ini bertujuan untuk mengidentifikasi serta memetakan kualitas air sumur bor warga Kota Sorong berdasarkan parameter fisik dan kimia. Pengukuran parameter fisik terdiri dari turbidity (kekeruhan), salinitas, konduktivitas, TDS, ORP dan parameter kimia terdiri dari pH, DO, dan Fe. Sampel yang digunakan pada penelitian ini terdiri dari empat belas titik sumur bor warga yang tersebar di Kota Sorong, data hasil pengukuran sampel yang dilakukan secara in-situ (pengukuran langsung di lapangan). Dari hasil analisa 28,57 % titik sampel yang memenuhi baku mutu kelas II, III dan IV, 21,43 % yang memenuhi baku mutu kelas III, dan 50 % titik sampel yang hanya memenuhi baku mutu kelas IV. Adapun hasil kualitas air sumur bor warga Kota Sorong diolah dengan menggunakan aplikasi sofware untuk pemetaan arcgis dengan parameter TDS 100 % memenuhi baku mutu, pH 92,8 % memenuhi baku mutu, FE 50 % memenuhi baku mutu, dan DO untuk kelas II 25 % memenuhi baku mutu, kelas III 21,4% memenuhi baku mutu, dan kelas IV 50 % memenuhi baku mutu.
Pengaruh Kadar Semen Terhadap Stabilitas Tanah Lempung Ditinjau Dari Kuat Geser Tanah
Authors: Purwati Wulan Novita , Rokhman Rokhman , Pristianto Hendrik
Published: January 2020

Stabilitas tanah merupakan salah satu usaha untuk meningkatkan kapasitas daya dukung tanah. Tanah lempung plastisitas tinggi berpotensi menjadi tanah yang bermasalah karena mempunyai kekuatan rendah dan penurunan yang tinggi. Salah satu metode untuk meningkatkan daya dukung adalah stabilisasi tanah lempung salah satunya menggunakan Portland Cement Type I. Penelitian ini diharapkan untuk mengetahui seberapa besar pengaruh perubahan semen terhadap nilai kuat geser tanah. Dalam penelitian ini tanah yang digunakan berasal dari Jalan Makam Kelurahan Malason, Distrik Aimas, Kabupaten Sorong. Pengujian tanah ini terdiri dari pengujian fisik dan mekanis, pengujian yang utama dilakukan adalah pengujian Direct Shear Test (Uji Kuat Geser Langsung) yang dilakukan di Laboratorium Mekanika Tanah Fakultas Teknik Universitas Muhammadiyah Sorong dan berpedoman pada SNI dengan variasi campuran semen sebesar 2%, 4%, 6%, 8% dan 10%. Dari hasil penelitian didapatkan bahwa semakin besar variasi semen maka tegangan geser, kohesi dan sudut geser semakin meningkat. Nilai tegangan geser, kohesi dan sudut geser yang tertinggi pada penambahan bahan stabilitas sebesar 10% dengan waktu pemeraman 3 hari dengan nilai tegangan geser 0,541 kg/cm² kohesi sebesar 0,172 Kg/cm² dan sudut geser sebesar 42,62°. Hal ini menunjukan bahwa semen dapat dijadikan bahan stabilisasi untuk meningkatkan kekuatan dan daya dukung tanah lempung ditinjau dari peningkatan nilai tegangan geser, kohesi tanah dan sudut geser yang dihasilkan.
Retailers of the Lviv region
Authors: Klapchuk Viktoria A. , Lozynskyy Roman M.
Published: January 2020

We analyzed trading networks operating in the territory of the Lviv region. Also we determined the fraction of each retailers in the general structure of the retailers by region coverage. The research objects are 251 modern trade establishments, represented by such formats as minimarket, supermarket, hypermarket, discounters and cash & carry. The article analyzes the spatial development of the retail chains of Lviv as the largest city in the Lviv region. Determination of geospatial organization of the Lviv retailers allow us to identify perspective areas for the development of retailers. In the course of the research, it was found that one of the key indicators, in addition to the numbers of networks, is the general trading area of their establishments, after all it reflects the possibilities of the retailer’s in customer service. The largest areas, as a rule, have establishments in international trade networks, somewhat smaller – national networks, the smallest, respectively, in local area networks. For getting the complete information about the area of the trading establishments we used GIS methods. According to the received results, it was determined that the largest average area of retail establishments has international trade networks, and despite their small number, their fraction from the general is one of the largest. Using different indicators we created a database for cluster analysis, which makes possible to combine regions and cities of regional significance into certain groups according to the similarity of indicators. According to the results of the analysis, the districts of Lviv region were divided into 6 groups, and cities of regional significance for 4 groups. Received results can be used to determine the accessibility of the population to modern trade establishments, thus showing the level of development of social benefits, and also to create the investment attractiveness of some districts of the Lviv region.
ANALISIS PENGARUH KONSUMSI KOPI DENGAN DENYUT JANTUNG PADA PEMUDA
Authors: Rahayu Monita
Published: January 2020

Penelitian ini bertujuan untuk mengetahui pengaruh konsumsi kafein khususnya kopi terhadap denyut jantung seseorang. Penelitian dilakukan pada pemuda RW 04 Pondok Kacang Barat Tangerang Selatan. Kafein yang merupakan zat yang banyak terkandung dalam kopi, teh, minuman cola, minuman berenergi, coklat, serta banyak digunakan untuk berbagai macam terapi kesehatan memiliki efek samping terhadap kardiovaskular atau jantung berkaitan dengan hal tersebut maka perlu dilakukan penelitian lanjutan untuk mengetahui ada atau tidaknya peningkatan denyut jantung setelah mengkonsumsi kopi. Merupakan penelitian kuantitatif dan pengambilan sampel secara random. Analisis data menggunakan SPSS dengan jumlah sampel 60 orang. Hasil penelitian ini terdapat pengaruh positif antara konsumsi kafein terhadap denyut jantung seseorang. Kata kunci : kopi, denyut jantung
Moderating Role of Stress, Anxiety, and Depression in the Relationship Between Tinnitus and Hearing Loss Among Patients
Authors: Ahmed Ammar , Aqeel Muhammad , Akhtar Tanvir , Salim Sammeen , Ahmed Bashir
Published: January 2020

Adaptation level theory of tinnitus and neuropsychological theory of tinnitus are extensively used frameworks for understanding emotional and psychological distress among tinnitus sufferers. Objective of the present study was to investigate potential associations between hearing loss, tinnitus, anxiety, depression, and stress. The Tinnitus Handicap Inventory (Newman, Jacobson, & Spitzer, 1996) and the Depression, Anxiety, Stress Scale (Lovibond & Lovibond, 1995)scales were administered to a sample of 110 tinnitus outpatients recruited from Audiology departments of Lahore and Rawalpindi hospitals. Results revealed tinnitus was positively linked with psychological problems. Additionally, it was established that tinnitus is a positive significant predictor for anxiety, stress and depression. The moderation models related to the interactions between psychological problems and hearing loss were negative significant predictors for tinnitus symptoms. Moreover, the comparative analysis between gender differences revealed a significant diversity in the levels of stress, anxiety, and depression. Results also elucidated that patients at initial stages of hearing loss were more prone towards reporting tinnitus symptoms along with emerging psychological problems.
Influence of Organizational Justice, Supervisor Support, and Group Cohesiveness on Organizational Commitment: Mediated Role of Ethical Behavior
Authors: Mushtaq Rabia , Ellahi Abida , Bashir Khan Muhammad
Published: January 2020

Present study contributes to the ethical behavior field by assessing the role of justice, supervisor support, and group cohesiveness indirectly effecting organizational commitment through ethical behavior. Data were collected through onsite administration of a survey on individuals working in 12 companies of three different sectors including Pakistan Airlines, banks, and a Fast Food Services in Pakistan. Measures related to Organizational Commitment (Meyer & Allen, 1997), Ethical Behavior (Hunt, Chonko, & Wilcox, 1984), Distributive Justice (Price & Mueller, 1986), Procedural Justice (Moorman, 1991), Supervisor Support (Greenhauset al.,1990), and Group Cohesion Seashore’s (1954) were administered on the sample. The results supported the role of ethical behavior as a mediator. Organizational justice, supervisor support, ans group cohesiveness depicted significant association with organizational commitment. The findings showed that initiating action factors like supervisor support, justice in the organization, and harmony among employees tasks reciprocate through affirmative employees’ behaviour as honesty, fairness, equality, dignity, etc. which enhances the attachment level of employees with organization as well as employees’ stress level is reduced in encouraging work environment. The results provide useful insights for managers and consultants, especially, of human resource (HR) to design training programs for employees to resolve novel issues related to ethical trepidations.
Effect of Carbon Emission and Human Errors on a Two-Echelon Supply Chain under Permissible Delay in Payments
Authors: Gilotra Manavi , Pareek Sarla , Mittal Mandeep , Dhaka Vinti
Published: January 2020

Environmental worries in production and inventory models have received large attention in inventory management literature. In this paper, an economic production model is proposed with two-echelon supply chain when trade credit is offered by the supplier. This paper proposes human errors of Type I and Type II due to fatigue and inexperience of the inspector during screening. It considers the use of energy for production along with greenhouse gases (GHG) emission from production and transportation operations. The developed model optimizes the environmental and economic performances of the supply chain. Our aim is to explore the effects of human errors during inspection on the emission cost, transportation cost and delay in payment on the replenishment of order sizes and the expected total profit of the retailer. A mathematical model is developed and numerical examples are provided to illustrate the solution procedure.
Influence of Hybrid Fibres on Bond Strength of Concrete
Authors: Naraganti Srinivasa Rao , Pannem Rama Mohan Rao , Putta Jagadeesh
Published: January 2020

Bond strength between embedded bar and concrete plays vital role in the design of various reinforced concrete structural elements. Use of metallic and synthetic fibres has been shown to be an effective method to enhance tensile strength, reduce shrinkage and improve durability properties of concrete. However, making of synthetic fibres will not only deplete the natural hydrocarbon resources, but also add greenhouse pollutants to the environment. Hence, sisal fibre was considered as a potential alternative to polypropylene fibre. An experimental study was conducted to evaluate the influence of sisal fibres as mono-fibre and in combination with steel as hybrid fibre on bond strength of concrete. The performance of steel polypropylene fibre reinforced concrete (SPFRC) is compared with that of steel sisal fibre reinforced concrete (SSiFRC). Bond strength was conducted onM30 grade concrete for curing periods of 7, 28 and 90 days. Fibre dosages of 0.50%, 1.00%, 1.25% and 1.50% by volume of concrete were used. Results indicated that increase in steel fibre dosage improved the bond strength slightly. However, increase in fibre dosage of either PP fibres or sisal fibres resulted decrease in bond strength. Furthermore, sisal fibre reinforced concrete (SiFRC) showed inferior performance in bond strength as compared to polypropylene fibre reinforced concrete (PFRC). A detailed statistical analysis revealed that although no strong correlation between the compressive strength and the bond strength was evident from the experimental study, means of bond strength of both the hybrid groups did not differ significantly. In addition, empirical equations were proposed to predict the bond strength of fibre reinforced concrete (FRC) based on compressive strength.
Pre-Grazing Herbage Mass Affects Grazing Behavior, Herbage Disappearance, and the Residual Nutritive Value of a Pasture during the First Grazing Session
Authors: Piña Luis F. , Balocchi Oscar A. , Keim Juan Pablo , Pulido Rubén G. , Rosas Felipe
Published: January 2020

During the first hours after the allocation of a grazing strip (first grazing session, GS), dairy cows eat most of the daily dry matter (DM) available. There are few studies that analyze how the grazing-down process changes the characteristics of the pasture during the first GS. The objective of this study was to evaluate the effect of two pre-grazing herbage masses (HM; medium herbage mass (MHM) and high herbage mass (HHM) on the DM disappearance, grazing behavior of dairy cows, and the residual nutritive value of a pasture during the first GS. Two groups of twelve dairy cows were used to evaluate the grazing-down process, during a period of 62 days. The pre-grazing HM modified the bite rate, bite mass, and dry matter intake during the first GS. The pre-grazing HM affected the process of herbage disappearance of the pasture, especially during the first 60 min of the GS. The nutrient selection differential for acid detergent fiber was greater for HHM compared with MHM (0.93 vs. 0.86). In conclusion, pre-grazing HM affects the structural characteristics and the residual nutritive value of the pasture. The grazing process in the first GS was modified by the HM, affecting the defoliation and the DM disappearance rate of the pasture.
Importance of Basic Research on the Causes of Feather Pecking in Relation to Welfare
Authors: Fijn Lisa B. , van der Staay F. Josef , Goerlich-Jansson Vivian C. , Arndt Saskia S.
Published: January 2020

Feather pecking is a prominent issue in the commercial egg industry, associated with economic losses and welfare problems. A non-systematic literature search suggests that studies on feather pecking are predominantly concerned with applied research goals. That is to say, they aim to solve or diminish the effects of this problematic behavior by orienting towards practical approaches. The strong emphasis on this research approach has skewed our knowledge of the causes of feather pecking in relation to welfare. While the need for such research is high, there is an equivalent need for basic research that has not received corresponding effort. Also, current research predominantly focuses on the negative effects on the birds being pecked, whereas too little attention is given to the possible welfare problems of the peckers. We argue that more basic research is needed for obtaining comprehensive science-based knowledge of behavioral needs and abilities of hens, in particular with respect to behavioral problems that threaten their welfare.
The Use of Antioxidants in the Treatment of Migraine
Authors: Goschorska Marta , Gutowska Izabela , Baranowska-Bosiacka Irena , Barczak Katarzyna , Chlubek Dariusz
Published: January 2020

Despite numerous studies concerning the pathophysiology of migraine, the exact molecular mechanism of disturbances underlying migraine is still unknown. Furthermore, oxidative stress is considered to play a significant role in migraine pathogenesis. The notion of oxidative stress in migraine patients has been discussed for several decades. Over the past few years, among the substances that could potentially be used for migraine treatment, particular attention has been paid to the so-called nutraceutics, including antioxidants. Antioxidants supplied with food prevent oxidative stress by inhibiting initiation, propagation, and the oxidative chain reaction itself. Additionally, the agents used so far in the prevention of migraine indeed show some anti-oxidative action. The antioxidants discussed in the present paper are increasingly more often used by migraine patients not only due to mild or even a lack of side effects but also because of their effectiveness (decreased frequency of migraine episodes or shortening of an episode duration). The present review provides a summary of the studies on nutraceuticals with antioxidative properties.
Spontaneous Subarachnoid Hemorrhage in a Patient with a Co-Existent Posterior Communicating Artery Aneurysm and Cervical Spine Aneurysm Associated with Ventral Arterio-Venous Fistula
Authors: Hejčl Aleš , Lodin Jan , Cihlář Filip , Sameš Martin
Published: January 2020

Severe spontaneous subarachnoid hemorrhage (SAH) is predominantly caused by aneurysm rupture, with non-aneurysmal vascular lesions representing only a minority of possible causes. We present the case of a 58-year old lady with a coincidental posterior communicating artery (PCom) aneurysm and a high cervical spine arterio-venous fistula associated with a small ruptured aneurysm. After the emergency clipping of the PCom aneurysm, additional diagnostic procedures—repeated digital subtraction angiography and spinal magnetic resonance imaging, revealed the actual cause of the SAH, a type-A ventral intradural fistula at cervical level C2/3. The fistula was treated micro surgically via a ventral approach using C3 somatectomy and C2-4 stabilization after the initial failure of endovascular therapy. Furthermore, the patient was treated for complications associated with severe SAH, including acute hydrocephalus and meningitis. In cases where the SAH pattern and perioperative findings do not suggest an intracranial aneurysm as the source of SAH, further diagnostic investigation is warranted to discover the real cause. Patients with severe non-aneurysmal SAH require a similar algorithm in diagnosing the cause of the hemorrhage as well as complex conditions such as ruptured aneurysms.
Low Dosed Curcumin Combined with Visible Light Exposure Inhibits Renal Cell Carcinoma Metastatic Behavior in Vitros
Authors: Rutz Jochen , Maxeiner Sebastian , Justin Saira , Bachmeier Beatrice , Bernd August , Kippenberger Stefan , Zöller Nadja , Chun Felix K.-H. , Blaheta Roman A.
Published: January 2020

Recent documentation shows that a curcumin-induced growth arrest of renal cell carcinoma (RCC) cells can be amplified by visible light. This study was designed to investigate whether this strategy may also contribute to blocking metastatic progression of RCC. Low dosed curcumin (0.2 µg/mL; 0.54 µM) was applied to A498, Caki1, or KTCTL-26 cells for 1 h, followed by exposure to visible light for 5 min (400–550 nm, 5500 lx). Adhesion to human vascular endothelial cells or immobilized collagen was then evaluated. The influence of curcumin on chemotaxis and migration was also investigated, as well as curcumin induced alterations of α and β integrin expression. Curcumin without light exposure or light exposure without curcumin induced no alterations, whereas curcumin plus light significantly inhibited RCC adhesion, migration, and chemotaxis. This was associated with a distinct reduction of α3, α5, β1, and β3 integrins in all cell lines. Separate blocking of each of these integrin subtypes led to significant modification of tumor cell adhesion and chemotactic behavior. Combining low dosed curcumin with light considerably suppressed RCC binding activity and chemotactic movement and was associated with lowered integrin α and β subtypes. Therefore, curcumin combined with visible light holds promise for inhibiting metastatic processes in RCC.
Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma
Authors: H.S. Richter Günther , Hensel Tim , Schmidt Oxana , Saratov Vadim , von Heyking Kristina , Becker-Dettling Fiona , Prexler Carolin , Yen Hsi-Yu , Steiger Katja , Fulda Simone , Dirksen Uta , Weichert Wilko , Wang Shudong , Burdach Stefan , Schäfer Beat W.
Published: January 2020

Background: Previously, we used inhibitors blocking BET bromodomain binding proteins (BRDs) in Ewing sarcoma (EwS) and observed that long term treatment resulted in the development of resistance. Here, we analyze the possible interaction of BRD4 with cyclin-dependent kinase (CDK) 9. Methods: Co-immunoprecipitation experiments (CoIP) to characterize BRD4 interaction and functional consequences of inhibiting transcriptional elongation were assessed using drugs targeting of BRD4 or CDK9, either alone or in combination. Results: CoIP revealed an interaction of BRD4 with EWS-FLI1 and CDK9 in EwS. Treatment of EwS cells with CDKI-73, a specific CDK9 inhibitor (CDK9i), induced a rapid downregulation of EWS-FLI1 expression and block of contact-dependent growth. CDKI-73 induced apoptosis in EwS, as depicted by cleavage of Caspase 7 (CASP7), PARP and increased CASP3 activity, similar to JQ1. Microarray analysis following CDKI-73 treatment uncovered a transcriptional program that was only partially comparable to BRD inhibition. Strikingly, combined treatment of EwS with BRD- and CDK9-inhibitors re-sensitized cells, and was overall more effective than individual drugs not only in vitro but also in a preclinical mouse model in vivo. Conclusion: Treatment with BRD inhibitors in combination with CDK9i offers a new treatment option that significantly blocks the pathognomonic EWS-ETS transcriptional program and malignant phenotype of EwS.
Targeting CD47 as a Novel Immunotherapy for Multiple Myeloma
Authors: Sun Jennifer , Muz Barbara , Alhallak Kinan , Markovic Matea , Gurley Shannon , Wang Zhe , Guenthner Nicole , Wasden Katherine , Fiala Mark , King Justin , Kohnen Daniel , Salama Noha Nabil , Vij Ravi , Azab Abdel Kareem
Published: January 2020

Multiple myeloma (MM) remains to be incurable despite recent therapeutic advances. CD47, an immune checkpoint known as the “don’t eat me” signal, is highly expressed on the surface of various cancers, allowing cancer cells to send inhibitory signals to macrophages and impede phagocytosis and immune response. In this study, we hypothesized that blocking the “don’t eat me” signaling using an anti-CD47 monoclonal antibody will induce killing of MM cells. We report that CD47 expression was directly correlated with stage of the disease, from normal to MGUS to MM. Moreover, MM cells had remarkably higher CD47 expression than other cell populations in the bone marrow. These findings indicate that CD47 is specifically expressed on MM and can be used as a potential therapeutic target. Further, blocking of CD47 using an anti-CD47 antibody induced immediate activation of macrophages, which resulted in induction of phagocytosis and killing of MM cells in the 3D-tissue engineered bone marrow model, as early as 4 hours. These results suggest that macrophage checkpoint immunotherapy by blocking the CD47 “don’t eat me” signal is a novel and promising strategy for the treatment of MM, providing a basis for additional studies to validate these effects in vivo and in patients.
Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective
Authors: Liarte Sergio , Bernabé-García Ángel , Nicolás Francisco J.
Published: January 2020

Chronic wounds are characterized for their incapacity to heal within an expected time frame. Potential mechanisms driving this impairment are poorly understood and current hypotheses point to the development of an unbalanced milieu of growth factor and cytokines. Among them, TGF-β is considered to promote the broadest spectrum of effects. Although it is known to contribute to healthy skin homeostasis, the highly context-dependent nature of TGF-β signaling restricts the understanding of its roles in healing and wound chronification. Historically, low TGF-β levels have been suggested as a pattern in chronic wounds. However, a revision of the available evidence in humans indicates that this could constitute a questionable argument. Thus, in chronic wounds, divergences regarding skin tissue compartments seem to be characterized by elevated TGF-β levels only in the epidermis. Understanding how this aspect affects keratinocyte activities and their capacity to re-epithelialize might offer an opportunity to gain comprehensive knowledge of the involvement of TGF-β in chronic wounds. In this review, we compile existing evidence on the roles played by TGF-β during skin wound healing, with special emphasis on keratinocyte responses. Current limitations and future perspectives of TGF-β research in chronic wounds are discussed.
From Genetic Alterations to Tumor Microenvironment: The Ariadne’s String in Pancreatic Cancer
Authors: Bazzichetto Chiara , Conciatori Fabiana , Luchini Claudio , Simionato Francesca , Santoro Raffaela , Vaccaro Vanja , Corbo Vincenzo , Falcone Italia , Ferretti Gianluigi , Cognetti Francesco , Melisi Davide , Scarpa Aldo , Ciuffreda Ludovica , Milella Michele
Published: January 2020

The threatening notoriety of pancreatic cancer mainly arises from its negligible early diagnosis, highly aggressive progression, failure of conventional therapeutic options and consequent very poor prognosis. The most important driver genes of pancreatic cancer are the oncogene KRAS and the tumor suppressors TP53, CDKN2A, and SMAD4. Although the presence of few drivers, several signaling pathways are involved in the oncogenesis of this cancer type, some of them with promising targets for precision oncology. Pancreatic cancer is recognized as one of immunosuppressive phenotype cancer: it is characterized by a fibrotic-desmoplastic stroma, in which there is an intensive cross-talk between several cellular (e.g., fibroblasts, myeloid cells, lymphocytes, endothelial, and myeloid cells) and acellular (collagen, fibronectin, and soluble factors) components. In this review; we aim to describe the current knowledge of the genetic/biological landscape of pancreatic cancer and the composition of its tumor microenvironment; in order to better direct in the intrinsic labyrinth of this complex tumor type. Indeed; disentangling the genetic and molecular characteristics of cancer cells and the environment in which they evolve may represent the crucial step towards more effective therapeutic strategies