bluuebunny/crossref_metadata_2025 huggingface dataset:
Reductions in hospitalisations and emergency department visits with early antibiotic initiation in nontuberculous mycobacterial lung disease
Authors: Winthrop Kevin , Waweru Catherine , Hassan Mariam , Burns Sara , Lucci Matthew , Chatterjee Anjan
Published: March 2024

Background

While antibiotics are recommended for treatment of nontuberculous mycobacterial lung disease (NTMLD), the impact of early antibiotic initiation on healthcare resource utilisation is unclear. This study compared healthcare resource utilisation with earlyversusdelayed antibiotic initiation in NTMLD.

Methods

A retrospective, claims database study (Merative MarketScan) of patients diagnosed with NTMLD between 1 July 2015 and 30 June 2019. Patients were divided into early antibiotic initiation,i.e.≤3 months after the first medical claim for NTMLD (index date), and delayed antibiotic initiation groups. Hospitalisations and outpatient visits during a 2-year post-index period were compared to baseline per treatment group; a difference-in-difference analysis compared early and delayed antibiotic initiation groups adjusting for confounding.

Results

Out of 481 NTMLD treated patients, 364 (76%) and 117 (24%) comprised the early and delayed antibiotic initiation groups, respectively. The early antibiotic initiation group showed significant reductions from baseline in hospitalisations (all-cause, respiratory) and emergency department (ED) visits at follow-up. A significant increase from baseline in mean number of hospitalisations per patient was observed in the delayed antibiotic initiation group in year 1 post-index. Compared to delayed antibiotic initiation, the early antibiotic initiation group showed significantly greater reductions in all-cause hospitalisations in years 1 and 2 post-index (relative risk 0.62 (95% CI 0.41–0.95) and 0.62 (95% CI 0.39–0.98), respectively), and in respiratory-related hospitalisations.

Conclusions

The early antibiotic initiation group showed significant reductions from baseline in hospitalisations and ED visits over time. Compared to delayed antibiotic initiation, early antibiotic initiation was associated with significantly greater reductions in hospitalisations.
Total sputum nitrate/nitrite is associated with exacerbations andPseudomonas aeruginosacolonisation in bronchiectasis
Authors: Zhou Yaya , He Xinliang , Tang Jian , Zhang Dongmei , Liu Yao , Xue Yu'e , Jiang Nanchuan , Zhang Jianchu , Wang Xiaorong
Published: March 2024

Background

Sputum nitrate/nitrite, which is the main component of reactive nitrogen species, is a potential biomarker of disease severity and progression in bronchiectasis. This study aimed to determine the association between nitrate/nitrite and exacerbations and airway microbiota in bronchiectasis.

Methods

We measured total nitrate/nitrite concentration in sputum samples collected from 85 patients with stable bronchiectasis, performed 16S ribosomal RNA sequencing of sputum samples and predicted the denitrification ability of airway microbiota using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). Relationships between sputum total nitrate/nitrite and disease severity, exacerbations and airway microbiota were examined.

Results

Higher total sputum nitrate/nitrite was associated with more severe bronchiectasis defined by E-FACED (exacerbation, forced expiratory volume in 1 s, age, chronic colonisation byPseudomonas aeruginosa, radiological extension and dyspnoea) (p=0.003) or Bronchiectasis Severity Index (p=0.006) and more exacerbations in the prior 12 months (p=0.005). Moreover, total sputum nitrate/nitrite was significantly higher in patients with worse cough score (p=0.03), worse sputum purulence score (p=0.01) and worse Medical Research Council dyspnoea score (p=0.02). In addition, the total sputum nitrate/nitrite of theP. aeruginosacolonised (PA) group was higher than that of the non-P. aeruginosacolonised (NPA) group (p=0.04), and the relative abundance ofP. aeruginosawas positively correlated with total nitrate/nitrite (r=0.337, p=0.002). Denitrification module (M00529) was also significantly enriched in the PA group compared to the NPA group through PICRUSt analyses. Using receiver-operating characteristic analysis, total nitrate/nitrite was associated with exacerbations during 1-year follow-up (area under the curve 0.741, p=0.014).

Conclusions

Sputum nitrate/nitrite is a biomarker of disease severity and associated withP. aeruginosacolonisation in bronchiectasis.
Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients
Authors: Pahari Purbanka , Korkalainen Henri , Arnardóttir Erna Sif , Islind Anna Sigridur , August Elias , Oksenberg Arie , Töyräs Juha , Leppänen Timo , Nikkonen Sami
Published: March 2024

Introduction

Intermittent hypoxaemia is closely associated with cardiovascular dysfunction and may be a more accurate indicator of obstructive sleep apnoea (OSA) severity than conventional metrics. Another key factor is the lung-to-finger circulation time (LFCt), defined as the duration from the cessation of a respiratory event to the lowest point of oxygen desaturation. LFCt serves as a surrogate marker for circulatory delay and is linked with cardiovascular function. Yet, the specific associations between respiratory and hypoxaemia characteristics and LFCt in patients with OSA remain unclear. This study aims to investigate these associations, ultimately contributing to a more nuanced understanding of OSA severity.

Methods

The study comprised 878 in-lab polysomnographies of patients with suspected OSA. The conventional OSA metrics were computed along with nine hypoxaemia metrics and then divided into quartiles (Q1–Q4) based on respiratory event duration. In addition, these were further divided into subquartiles based on LFCt. The empirical cumulative distribution functions (CDFs) and linear regression models were used to investigate the association between desaturation metrics and LFCt.

Results

The results showed that prolonged LFCt was associated with increased hypoxic severity. Based on CDFs, the hypoxic severity significantly increased with longer LFCt despite the duration of respiratory events. Furthermore, fall duration was elevated in patients with longer LFCt (Q1- desaturation fall duration (FallDur): 14.6 s; Q4-FallDur: 29.8 s; p<0.0001). The regression models also showed significant association between hypoxic severity and LFCt (Q1-desaturation fall slope (FallSlope): β=−3.224; Q4-FallSlope: β=−6.178; p<0.0001).

Discussion

Considering LFCt along with desaturation metrics might be useful in estimating the association between the severity of OSA, physiological consequences of respiratory events and cardiac health.
Heuristic Expanding Disconnected Graph: A Rapid Path Planning Method for Mobile Robots
Authors: Tao Yong , Duan Lian , Gao He , Zhang Yufan , Song Yian , Wang Tianmiao
Published: March 2024

Existing mobile robots mostly use graph search algorithms for path planning, which suffer from relatively low planning efficiency owing to high redundancy and large computational complexity. Due to the limitations of the neighborhood search strategy, the robots could hardly obtain the most optimal global path. A global path planning algorithm, denoted as EDG*, is proposed by expanding nodes using a well-designed expanding disconnected graph operator (EDG) in this paper. Firstly, all obstacles are marked and their corners are located through the map pre-processing. Then, the EDG operator is designed to find points in non-obstruction areas to complete the rapid expansion of disconnected nodes. Finally, the EDG* heuristic iterative algorithm is proposed. It selects the candidate node through a specific valuation function and realizes the node expansion while avoiding collision with a minimum offset. Path planning experiments were conducted in a typical indoor environment and on the public dataset CSM. The result shows that the proposed EDG* reduced the planning time by more than 90% and total length of paths reduced by more than 4.6%. Compared to A*, Dijkstra and JPS, EDG* does not show an exponential explosion effect in map size. The EDG* showed better performance in terms of path smoothness, and collision avoidance. This shows that the EDG* algorithm proposed in this paper can improve the efficiency of path planning and enhance path quality.
A survivor with unexplained chest scars
Authors: Donner Viviane , Affaticati Mathieu , Izydorczyk Elodie , Cereghetti Sara
Published: March 2024

This case illustrates chest scars after piston-based chest compression device resuscitation and raises the awareness of the potential benefits of following up survivors of critical illness.
Species and structural diversity of trees at the structural type level
Authors: Li Yuanfa , Wei Liting
Published: March 2024

Background

Species and structural diversity are important for understanding the formation of forest communities, key ecological processes, and improving forest ecological functions and services, but their spatial characteristics have received little attention. Based on the spatial relationships among neighbouring trees, we proposed to divide trees within a structural unit into 15 structural types, and used the univariate distributions of the uniform angle index (W), mingling (M), and dominance (U), along with four common species diversity indices, to analyse the diversity of structural types in natural forests near the Tropic of Cancer.

Results

Only a portion of clumped class maintained aggregation, most exhibited a random pattern. Species mixture increased exponentially across distribution classes, and abundance and richness exhibited an initial increase followed by a slight decrease. The distribution patterns of mixture classes varied from highly clustered to random, and M distributions gradually shifted from an inverted J-shaped curve to a J-shaped curve. Abundance and richness exhibited an exponential distribution, whereas the Shannon–Wiener index increased linearly. The W distribution of differentiation classes approximated a normal distribution, whereas M distributions exhibited a J shape. The U distribution of each structure type was approximately 0.2.

Conclusions

These results reveal the species and structural diversity characteristics of trees at the structural type level and expand our knowledge of forest biodiversity. The new method proposed here should significantly contribute to biodiversity monitoring efforts in terrestrial ecosystems, and suggests that higher standards for the simulation and reconstruction of stand structure, as well as thinning in near-natural forests, is warranted.
Assessment of the E-value in the presence of bias amplification: a simulation study
Authors: Barrette Eric , Higuera Lucas , Wherry Kael
Published: March 2024

Background

The E-value, a measure that has received recent attention in the comparative effectiveness literature, reports the minimum strength of association between an unmeasured confounder and the treatment and outcome that would explain away the estimated treatment effect. This study contributes to the literature on the applications and interpretations of E-values by examining how the E-value is impacted by data with varying levels of association of unobserved covariates with the treatment and outcome measure when covariate adjustment is applied. We calculate the E-value after using regression and propensity score methods (PSMs) to adjust for differences in observed covariates. Propensity score methods are a common observational research method used to balance observed covariates between treatment groups. In practice, researchers may assume propensity score methods that balance treatment groups across observed characteristics will extend to balance of unobserved characteristics. However, that assumption is not testable and has been shown to not hold in realistic data settings. We assess the E-value when covariate adjustment affects the imbalance in unobserved covariates.

Methods

Our study uses Monte Carlo simulations to evaluate the impact of unobserved confounders on the treatment effect estimates and to evaluate the performance of the E-Value sensitivity test with the application of regression and propensity score methods under varying levels of unobserved confounding. Specifically, we compare observed and unobserved confounder balance, odds ratios of treatment vs. control, and E-Value sensitivity test statistics from generalized linear model (GLM) regression models, inverse-probability weighted models, and propensity score matching models, over correlations of increasing strength between observed and unobserved confounders.

Results

We confirm previous findings that propensity score methods – matching or weighting – may increase the imbalance in unobserved confounders. The magnitude of the effect depends on the strength of correlation between the confounder, treatment, and outcomes. We find that E-values calculated after applying propensity score methods tend to be larger when unobserved confounders result in more biased treatment effect estimates.

Conclusions

The E-Value may misrepresent the size of the unobserved effect needed to change the magnitude of the association between treatment and outcome when propensity score methods are used. Thus, caution is warranted when interpreting the E-Value in the context of propensity score methods.
Analysis of related factors for sarco-osteoporosis in middle-aged and elderly inpatients and development and validation of a nomogram
Authors: Juan Peng Dao , Gao Feng Qiong , Lou Yijiao , Ma Yan , Xia Tongxia
Published: March 2024

Background

Sarco-osteoporosis is a skeletal muscle disease associated with aging and complex pathological factors. At present, there are few studies on the analysis of its related factors, and a nomogram to estimate the risk of sarco-osteoporosis in middle-aged and elderly patients is not available.

Methods

A total of 386 patients admitted to our hospital from October 2021 to October 2022 were collected, and the general demographic data and clinical data of the patients were collected.386 subjects were enrolled in the study and randomly divided into training set and validation set at a ratio of 7:3. In the training set, the Least absolute shrinkage and selection operator(LASSO)regression technique was used to select the optimal predictive features, and multivariate logistic regression was used to screen the factors associated with sarco-osteoporosis, and a nomogram was constructed using meaningful variables from multivariate analysis. The performance of the nomograms was assessed and validated by Area Under Curve (AUC) and calibration curves.

Results

There were no significant differences in baseline characteristic of individuals in training set and validation set, six variables with non-zero coefficients were screened based on LASSO regression in the training set. Multivariate logistic regression analysis showed that the related factors for sarco-osteoporosis in middle-aged and elderly inpatients included age (OR = 1.08, 95%CI 1.03 ∼ 1.14), regular exercise (OR = 0.29, 95%CI 0.15 ∼ 0.56), albumin (OR = 0.9, 95%CI 0.82 ∼ 0.98), height (OR = 0.93, 95%CI 0.88 ∼ 0.99) and lean mass index (OR = 0.66, 95%CI 0.52 ∼ 0.85), and a nomogram was constructed based on the above factors. AUC of nomogram were 0.868(95%CI 0.825 ∼ 0.912) in the training set and 0.737(95%CI 0.646 ∼ 0.828) in the validation set. Calibration curve analysis showed that the predicted probability of sarco-osteoporosis had high consistency with the actual probability, and the absolute error of the training set and verification set was 0.018 and 0.03, respectively.

Conclusions

Our research showed that the occurrence of sarco-osteoporosis was associated with age, regular exercise, albumin, height and lean mass index, and we have developed a nomogram that can be effectively used in the preliminary and in-depth risk prediction of sarco-osteoporosis in middle-aged and elderly hospitalized patients.
Influence of education level and gender of dental students on perception of dental aesthetics
Authors: Kovačić Ines , Miloš Manuela , Kurkutović Matej , Čelebić Asja , Petričević Nikola
Published: March 2024

Background

Fulfilling aesthetic norms is an imperative of modern society. Accordingly, aesthetics has found its important role in dental medicine. The aim was to study whether there is a difference in the perception of tooth shade change and anatomical variations of anterior maxillary teeth among dental students depending on the level of education, gender, and experience in assisting in a dental office.

Methods

The research was conducted among dental students via the Google Forms platform. Students evaluated the aesthetic acceptability of a smile on the unaltered, reference photograph (RP) and on the other 28 photographs in which the tooth shade (lighter and darker teeth), length (shortened central incisors, elongated, and beveled lateral incisors, elongated canines) and position (atypical and typical rotations and diastemas) of the upper maxillary teeth were altered by digital manipulation. The 1–10 assessment scale was used. Statistical analysis comprised one-way Kolmogorov-Smirnov test, X2 tests, t-test, and 3-way MANOVA.

Results

In the research 208 students participated, 113 were preclinical students, 104 assisted in dental office and 175 were females. There were no significant effects of gender regarding length and position modifications (p > .05), while women were stricter in evaluation of lighter shade (p < .05). Clinical students were stricter in evaluating all manipulated photographs (MP) except those towards darker shade modifications, while assisting in a dental office or having a dentist in close family showed no significant effects (p > .05).

Conclusions

With a higher level of targeted academic education, dental students sharpen their ability to notice deviations from the aesthetic norms of a smile.
Core components of end-of-life care in nursing education programs: a scoping review
Authors: Taheri-Ezbarami Zahra , Jafaraghaee Fateme , Sighlani Ali Karimian , Mousavi Seyed Kazem
Published: March 2024

Background

So far, there have been many studies on end-of-life nursing care education around the world, and in many cases, according to the cultural, social, and spiritual contexts of each country, the results have been different. The present study intends to gain general insight into the main components of end-of-life care in nursing education programs by reviewing scientific texts and the results of investigations.

Methods

This study was a scoping review conducted with the Arksey and O’Malley methodology updated by Peters et al. First, a search was made in Wos, ProQuest, Scopus, PubMed, Science Direct, Research Gate, and Google Scholar databases to find studies about end-of-life care education programs. Then, the screening of the found studies was done in four stages, and the final articles were selected based on the inclusion and exclusion criteria of the studies. Due to the nature of the research, editorials, letters, and commentaries were excluded. The screening steps are shown in the PRISMA-ScR diagram.

Results

23 articles related to end-of-life care education programs were reviewed. The studies included eleven descriptive and cross-sectional studies, two qualitative studies, eight interventional studies, one concept analysis article, and one longitudinal study. By summarizing the data from the studies, six themes were obtained as the main components of end-of-life care education: principles of end-of-life care, communication skills, physical considerations, psychosocial and spiritual considerations, ethical considerations, and after-death care.

Conclusion

End-of-life care is one of the most challenging nursing care in the world. Since many nurses are not prepared to provide such care, the information obtained from this review can help nursing education and treatment managers develop more comprehensive training programs to improve the quality of end-of-life care.
Insight into antioxidant-like activity and computational exploration of identified bioactive compounds in Talinum triangulare (Jacq.) aqueous extract as potential cholinesterase inhibitors
Authors: Afolabi Olakunle Bamikole , Olasehinde Oluwaseun Ruth , Owolabi Olutunmise Victoria , Jaiyesimi Kikelomo Folake , Adewumi Funmilayo Deborah , Idowu Olajumoke Tolulope , Mabayoje Samson Olatunde , Obajuluwa Adejoke Olukayode , Akpor Oghenerobor Benjamin
Published: March 2024

Background

Recent reports have highlighted the significance of plant bioactive components in drug development targeting neurodegenerative disorders such as Alzheimer’s disease (AD). Thus, the current study assessed antioxidant activity and enzyme inhibitory activity of the aqueous extract of Talinum triangulare leave (AETt) as well as molecular docking/simulation of the identified phytonutrients against human cholinesterase activities.

Methods

In vitro assays were carried out to assess the 2,2- azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) cation radicals and cholinesterase inhibitory activities of AETt using standard protocols. High performance liquid chromatography coupled with diode-array detection (HPLC–DAD) was employed to identify compounds in AETt. Also, for computational analysis, identified bioactive compounds from AETt were docked using Schrodinger's GLIDE against human cholinesterase obtained from the protein data bank (https://www.rcsb.org/).

Results

The results revealed that AETt exhibited a significant concentration-dependent inhibition against ABTS cation radicals (IC50 = 308.26 ± 4.36 µg/ml) with butylated hydroxytoluene (BHT) as the reference. Similarly, AETt demonstrated a significant inhibition against acetylcholinesterase (AChE, IC50 = 326.49 ± 2.01 µg/ml) and butyrylcholinesterase (BChE, IC50 = 219.86 ± 4.13 µg/ml) activities with galanthamine as the control. Molecular docking and simulation analyses revealed rutin and quercetin as potential hits from AETt, having showed strong binding energies for both the AChE and BChE. In addition, these findings were substantiated by analyses, including radius of gyration, root mean square fluctuation, root mean square deviation, as well as mode similarity and principal component analyses.

Conclusion

Overall, this study offers valuable insights into the interactions and dynamics of protein–ligand complexes, offering a basis for further drug development targeting these proteins in AD.
A closer look: obsessive-compulsive symptoms among intern nurses amidst COVID-19 pandemic
Authors: El-Sayed Mona Metwally , Elhay Eman Sameh Abd , Hawash Manal Mohammed , Sonbol Hassan Mohammed , Taha Samah Mohamed
Published: March 2024

Background

The distinctive circumstances and socio-cultural context in Egypt make it crucial to explore the psychological well-being of intern nurses amid the COVID-19 pandemic, with a specific focus on obsessive-compulsive symptoms. This study aimed to investigate the influence of fear of COVID-19 on obsessive-compulsive symptoms among intern nurses.

Methods

A cross-sectional survey involving 375 randomly recruited intern nurses was conducted. Data collected included the Fear of COVID-19 Scale and the Short Version of the Arabic Obsessive-Compulsive Scale.

Results

A significant relationship was found between the fear of COVID-19 and the severity of obsessive-compulsive symptoms among the participants (r = 0.472, p = 0.000). A stepwise regression analysis indicated that the fear of COVID-19, living in urban regions, frequency of COVID-19 infection, and increased number of infected family members may contribute to the severity of Obsessive-Compulsive Symptoms with adjusted R2 value = 27.5%.

Conclusion

The findings suggest that the COVID-19 pandemic has had significant psychological impacts on newly qualified nurses during their internship training period, including the manifestation of mental health symptoms such as Obsessive-Compulsive Symptoms. It was observed that urban residents, intern nurses with recurrent COVID-19 infections, and those with more infected family members exhibited a higher severity of OCS. These findings underscore the need for further research to investigate additional factors that may influence OCS severity.
Benchmark findings from a veteran electronic patient-reported outcomes evaluation from a chronic pain management telehealth program
Authors: Haun Jolie N. , Fowler Christopher A. , Smith Bridget M. , Cao Lishan , Stroupe Kevin T. , Lapcevic William A. , Saenger Michael S. , Benzinger Rachel C. , French Dustin D.
Published: March 2024

Background

Chronic pain is a leading cause of disability and negatively impacts biological/physical, psychological, and social aspects of life resulting in significant pain interference or disability. This project was part of a longitudinal mixed-methods implementation evaluation of the TelePain-Empower Veterans Program (EVP), a non-pharmacological chronic pain intervention. The purpose of this quality management project was to examine electronic patient-reported outcome measures (ePROs) including primary pain-related (intensity, interference, catastrophizing, kinesiophobia) and secondary outcomes (physical, psychological, acceptance, social) to determine TelePain-EVP effectiveness. Secondary purpose was to examine dosing effects to better understand potential dose relationships between EVP use and ePROs.

Methods

Standardized ePRO measures were examined at week 1 (baseline), week 10 (post-EVP), and week 26 (follow-up). Qualtrics, a cloud-based platform was used to collect ePRO data at each time point. Veterans that completed at-least one survey at any specified time point were categorized as responders (n = 221). Linear-mixed models (LMMs) were fit to assess changes for each primary and secondary ePRO.

Results

Participants ranged from 24 to 81 years old; veterans were typically male (65.16%), black or African American (76.47%), married or partnered (41.63%), attended at-least some college or vocational school (67.87%), and reported low back as their primary pain location (29.41%). There was a significant decrease in pain catastrophizing from baseline to post-TelePain-EVP (p < .001). However, pain catastrophizing improvement from baseline was not present at week 26 (p = .116). Pain interference also decreased from baseline to post-treatment (p = .05), but this improvement did not exceed the adjusted significance threshold. Additional pre-post improvements were also observed for certain secondary ePROs: psychological (anxiety, depression), acceptance (activities engagement). Only the activities engagement effect remained 26 weeks from baseline. Mixed results were observed for EVP dose across primary and secondary outcomes.

Conclusions

Evidence from this evaluation indicate that TelePain-EVP has positive outcomes for certain pain (catastrophizing), psychological (anxiety, depression), and acceptance (activities engagement) for veterans with chronic pain. More TelePain related studies and enterprise-wide evaluations are needed along with comparative and cost effectiveness methods to determine patient benefits and the economic value gained of treatment options such as TelePain-EVP.
Relationships between pig farm management and facilities and lung lesions' scores and between lung lesions scores and carcass characteristics
Authors: Kuberka Zbigniew , Mee John F. , Walaszek-Kayaoglu Aurelia , Klimowicz-Bodys Małgorzata D. , Dors Arkadiusz , Rząsa Anna
Published: March 2024

Background

The objective of this study was to examine the inter-relationships between pig farm management and facilities (as assessed by questionnaire) and post-mortem lung lesion (lung score assesment), which are the result of respiratory infections. The relationships between carcass characteristics and post-mortem lung lesion scores were also investigated.

Results

Questionnaire responses were collected from 22 self-selecting pig farmers about their farm facilities/management and health condition of the respiratory system of pigs, including the occurrence of clinical respiratory signs, results of laboratory testing for respiratory pathogens, and the use of respiratory vaccines. When fatteners were sent to the abattoir, their carcasses (n = 1,976) were examined for evidence of respiratory disease by lung lesion (pleuritis pneumonia-like (PP-like) and enzootic pneumonia-like (EP-like) lesions) scoring and the Actinobacillus pleuropneumoniae Index (APPI) was calculated. Carcass characteristics were recorded and, retrospectively, the prevalence of cachectic pigs was calculated. Using these variables, the relationships between farm facilities/management and lung lesions scores and the relationships between the latter and carcass characteristics and cachexia were explored. The key findings relating farm facilities and management to lung lesions were: slatted floors were associated with significantly higher EP-like lesions scores than litter bedding in weaners, single-stage fattening in the same building was associated with significantly higher EP-like lesions scores than two-stage fattening, but herd size, stocking density, use of all-in/all-out (AIAO) rule, technological break duration and variation in daily temperature did not affect lung lesions scores. The key findings relating lung lesion scores to carcass characteristics were: a significant, negative correlation between EP-like scores and carcass weight but not with other carcass characteristics, a significant positive correlation between PP-like scores and carcass meat content and prevalence of cachectic carcasses and a significant positive correlation between lung APPI and prevalence of cachectic carcasses.

Conclusions

It can be concluded that both farm facilities and management affect lung lesions scores and that the latter affect carcass characteristics. Lung lesion scoring is an inexpensive technique suitable for rapid monitoring of large numbers of carcasses that can be performed after animal slaughter. It provides useful information to inform producers about possible deficits in farm facilities or management and is a predictor of economic loss due to poorer quality carcasses.
Design and evaluation of mobile application for adolescents’ self-care: protocol for a randomized controlled field trial
Authors: Rezaee Razieh , Ghaffari Mohtasham , Rabiei Reza , Kavousi Amir , Rakhshanderou Sakineh
Published: March 2024

Background

Adolescence is a critical stage for the development of self-care. Many adolescents use mobile apps to monitor and improve their health. Health information technology plays a significant role in the field of self-care. This article provides a protocol for a study to design and evaluate mobile applications for adolescent self-care.

Methods

The present research is a combination of applied development study, methodological, and intervention experimental. This study will be done in three stages: The first stage is the design and evaluation of a mobile application for adolescent self-care. The second stage is, designing and evaluating the psychometric properties of the “Questionnaire for Measuring Adolescent Self-Care Performance.” This questionnaire will be used before and after using the application in the third stage. The third stage is determining the effectiveness of self-care interventions based on mobile applications among adolescents. The target group will be adolescents aged 10–19 from the schools of Amol City. In the first stage, the opinions of 30 people adolescents, parents, and experts will be used. In the second stage, the number of samples will be 10 times the number of items in the questionnaire. In the third stage, 50 people will be in the intervention group and 50 people will be in the control group. Descriptive statistics will be used for data analysis. Between-group and intra-group comparisons will be calculated about quantitative variables, independent t-test and paired t-test, and analysis of variance. The chi-square test and Fisher’s exact test will be used in SPSS 16 software to test the homogeneity of qualitative variables between the two groups.

Discussion

In the first stage, based on the opinions received from the target group, a user-centered educational application for self-care of adolescents will be designed. In the second stage, after determining the validity and reliability, a questionnaire will be designed to measure the self-care performance of adolescents. In the third stage, using an intervention study for 3 months, the effectiveness of the training will be determined through the designed application. Our findings are scheduled for a full analysis, with expectations that analyses will be completed by September 2023.
Sex differences in the physiological responses to cardiac rehabilitation: a systematic review
Authors: Bouakkar J. , Pereira T.J. , Johnston H. , Pakosh M. , Drake J. D. M. , Edgell H.
Published: March 2024

Background

Heart disease is one of the leading causes of death in Canada. Many heart disease patients are referred for cardiac rehabilitation, a multidisciplinary outpatient program often consisting of exercise training. Cardiac rehabilitation has been proven to be a successful secondary preventative measure in reducing mortality and improving overall health in heart disease patients, and its completion is important for both sexes as there is growing evidence that women benefit as much as men, if not more, with regard to mortality. It is important to note that previous studies have shown that healthy men and women respond differently to aerobic and resistance training, possibly due to hormones, body composition, autonomic and/or cardiovascular differences. However, evaluating sex differences in the efficacy of standard cardiac rehabilitation programs has not yet been fully explored with many studies investigating clinical or anthropometric data but not physiological outcomes. This systematic review aimed to investigate physiological differences in male and female heart disease patients after cardiac rehabilitation. The inclusion criteria were purposefully broad to encompass many cardiac rehabilitation scenarios, many cardiac disease states, and various program lengths and intensities with the intention of highlighting strengths and weaknesses of the current body of literature.

Methods

To conduct a synthesis without meta-analysis, a search strategy was generated to examine the relationships between heart disease patients, a supervised exercise program, physiological outcomes, and sex differences. The review was registered (Prospero: CRD42021251614) and the following databases were searched from inception to 19 December 2023: APA PsycInfo (Ovid), CINAHL Complete (EBSCOhost), Embase (Ovid), Emcare Nursing (Ovid), Medline All (Ovid; includes PubMed non-Medline), and Web of Science Core Collection. Eighty-eight studies pertaining to fitness, metabolism, body composition, respiratory function, cardiac function and C-reactive protein underwent data extraction.

Results and conclusions

Importantly, this review suggests that men and women respond similarly to a wide-range of cardiac rehabilitation programs in most physiological variables. However, many studies discussing maximal oxygen consumption, functional capacity, six-minute walk distances, and grip strength suggest that men benefit more. Further research is required to address certain limitations, such as appropriate statistical methods and type/intensity of exercise interventions.
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Authors: Mosquera Orgueira Adrián , Krali Olga , Pérez Míguez Carlos , Peleteiro Raíndo Andrés , Díaz Arias José Ángel , González Pérez Marta Sonia , Pérez Encinas Manuel Mateo , Fernández Sanmartín Manuel , Sinnet Daniel , Heyman Mats , Lönnerholm Gudmar , Norén-Nyström Ulrika , Schmiegelow Kjeld , Nordlund Jessica
Published: March 2024

Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still pose significant risks of mortality and long-term complications. To address this challenge, we employed a supervised machine learning technique, specifically random survival forests, to predict the risk of relapse and mortality using array-based DNA methylation data from a cohort of 763 pediatric ALL patients treated in Nordic countries. The relapse risk predictor (RRP) was constructed based on 16 CpG sites, demonstrating c-indexes of 0.667 and 0.677 in the training and test sets, respectively. The mortality risk predictor (MRP), comprising 53 CpG sites, exhibited c-indexes of 0.751 and 0.754 in the training and test sets, respectively. To validate the prognostic value of the predictors, we further analyzed two independent cohorts of Canadian (n = 42) and Nordic (n = 384) ALL patients. The external validation confirmed our findings, with the RRP achieving a c-index of 0.667 in the Canadian cohort, and the RRP and MRP achieving c-indexes of 0.529 and 0.621, respectively, in an independent Nordic cohort. The precision of the RRP and MRP models improved when incorporating traditional risk group data, underscoring the potential for synergistic integration of clinical prognostic factors. The MRP model also enabled the definition of a risk group with high rates of relapse and mortality. Our results demonstrate the potential of DNA methylation as a prognostic factor and a tool to refine risk stratification in pediatric ALL. This may lead to personalized treatment strategies based on epigenetic profiling.
Systemic risk assessment of Lithuanian second-pillar pension funds through connectedness and spillover
Authors: Kabašinskas Audrius
Published: March 2024

Pension funds are an essential part of retirement planning, and their performance and risks play a significant role in ensuring financial stability for retirees. This study aims to analyse the connectedness and spillover effects in the Lithuanian second-pillar pension fund market. The findings of this study provide insight on the interdependence within the second-pillar pension funds market and with other financial markets, and contribute to a better understanding of the risk-return trade-off of pension funds, especially during high-volatility periods. Differently from other studies in this paper market regimes are identified using Hidden Markov Models (HMM). Interdependence (including multivariate and non-linear) and causality between pension funds are analysed in different market regimes. Finally, returns spillover in different regimes is estimated using VAR and VECM models. The results of this paper are expected to be useful for pension fund managers, participants, and pension system supervisors in making decisions about investment strategies and in practices of systemic risk management regulation.
Specific emitter identification based on ensemble domain adversarial neural network in multi-domain environments
Authors: Li Dingshan , Yao Bin , Sun Pu , Li Peitong , Yan Jianfeng , Wang Juzhen
Published: March 2024

Specific emitter identification is pivotal in both military and civilian sectors for discerning the unique hardware distinctions inherent to various launchers, it can be used to implement security in wireless communications. Recently, a large number of deep learning-based methods for specific emitter identification have been proposed, achieving good performance. However, these methods are trained based on a large amount of data and the data are independently and identically distributed. In actual complex environments, it is very difficult to obtain reliable labeled data. Aiming at the problems of difficulty in data collection and annotation, and the large difference in distribution between training data and test data, a method for individual radiation source identification based on ensemble domain adversarial neural network was proposed. Specifically, a domain adversarial neural network is designed and a Transformer encoder module is added to make the features obey Gaussian distribution and achieve better feature alignment. Ensemble classifiers are then used to enhance the generalization and reliability of the model. In addition, three real and complex migration environments, Alpine–Montane Channel, Plain-Hillock Channel, and Urban-Dense Channel, were constructed, and experiments were conducted on WiFi dataset. The simulation results show that the proposed method exhibits superior performance compared to the other six methods, with an accuracy improvement of about 3%.
Response mechanism of soil microorganisms to simulated precipitation in the source wetland of Qinghai Lake
Authors: Wang Xinye , Zhang Ni , Chen Kelong , Chen Tiexi , Qi Desheng , Ma Yuanxi
Published: March 2024

Background

Changes in precipitation patterns crucially impact soil microbial communities, and the ecosystem in Qinghai-Tibet Plateau (QTP) is highly vulnerable to climate change. However, we do not fully understand how soil microbial communities in the source wetlands of QTP respond to changes in precipitation. In this study, we employed advanced techniques such as high-throughput sequencing and metabolomics to investigate how soil microbial communities in a source wetland of Qinghai Lake respond to changes in precipitation after quadrennial precipitation treatment.

Results

Our findings showed that the predominant microbiota in the source wetland was Proteobacteria. Interestingly, alterations in precipitation levels, whether increased or reduced, did not significantly impact the diversity or functional groups of the microbial community. However, the structure of the microbial community did respond notably to changes in precipitation, leading to shifts in the relative abundance of Spirochaetes and Treponema. A notable finding was that reduced precipitation levels (– 25% and − 50%) and mild increases in precipitation (25%) within the region contributed to increased soil carbon content. However, this effect ceased to manifest when precipitation increased by 50%. Additionally, the reduction in precipitation prompted the release of soil metabolites like syringic acid and aldosterone, while enhanced precipitation resulted in a decrease in aldosterone content.

Conclusions

Precipitation changes altered the relative abundance of soil microbial communities and metabolites, which was conducive to increasing carbon storage in this alpine wetland.
C-Test construct validity: Evidence from nonparametric item response theory
Authors: Shoahosseini Roya , Baghaei Purya , Khodabakhshzadeh Hossein , Ashraf Hamid
Published: March 2024

C-Test is a gap-filling test designed to measure first and second language proficiency. Over the past four decades, researchers have shown the fit of C-Test data to parametric item response theory (IRT) models, but no study so far has shown the fit of C-Tests to nonparametric IRT models. The purpose of this study is to contribute to the ongoing C-Test validation project by providing evidence of fit to the Mokken scale analysis as a widely used nonparametric IRT model. A six-passage C-Test battery was analyzed using the monotone homogeneity model and the double monotonicity model of Mokken. Unidimensionality was evaluated using the automatic item selection procedure. Findings showed that the C-Test passages form a strong unidimensional scale, fit well to the monotone homogeneity model, and, after deleting one item, have a sufficient fit to the double monotonicity model. The findings also indicated that the items form a hierarchy, and persons can be located on an ordinal scale using their C-Test sum scores. Implications of the study for C-Test validity and application are discussed.
English language teachers’ attitudes toward using electronic portfolio on Iranian EFL learners’ speaking: a grounded theory approach
Authors: Esmaeilee Soheila
Published: March 2024

In recent decades, technology has changed the methods of teaching and assessment in educational settings all over the world. One notable innovation that has gained prominence in English language teaching (ELT) is the utilization of e-portfolios to evaluate and enhance students’ writing and, potentially, speaking skills. While students have shown positive attitudes toward integrating e-portfolios in speaking classes, teachers’ attitudes toward this pedagogical method remain undisclosed. Therefore, this study investigates teachers’ attitudes toward e-portfolios in speaking classes based on the data collected from semi-structured and focused group interviews. The data was obtained from the Iran Language Institute (ILI), a leading institution for teaching English in Tehran. A grounded theory approach was used to analyze and evaluate 10 semi-structured interviews and focus groups. While some challenges are to overcome, teachers appear positive about implementing e-portfolios in speaking classes. As a result of teachers’ attitudes towards e-portfolios, four categories emerged: ownership and responsibility, reflection (peer and self), teacher self-improvement, and drawbacks.
Impact of skeletal muscle mass on postoperative complications in oral cancer surgery
Authors: Fujii Arisa , Suzuki Taiki , Sakai Katsuhiko , Matsuura Nobuyuki , Sugahara Keisuke , Katakura Akira , Nomura Takeshi
Published: March 2024

Background

Sarcopenia is characterized by a progressive and generalized loss of skeletal muscle mass and strength. The aim of this retrospective study was to investigate the impact of skeletal muscle mass on adverse events in free-flap reconstruction for defects after oral cancer resection.

Results

Of 120 patients, recipient-site adverse events occurred in 56 patients (46.7%), and recipient-site surgical site infections occurred in 45 patients (37.5%). Skeletal muscle index was significantly associated with recipient-site adverse events in univariate analysis (P < 0.05). Lower body mass index and skeletal muscle index were significantly associated with recipient-site surgical site infection in univariate analysis (P < 0.05). In the multiple logistic regression model, a lower skeletal muscle index was a significant risk factor for recipient-site adverse events and surgical site infections (adverse events odds ratio; 3.17/P = 0.04; surgical site infection odds ratio; 3.76/P = 0.02).

Conclusions

The SMI at level Th12 was an independent factor for postoperative AEs, especially SSI, in OSCC patients with free-flap reconstruction.
Enhanced revision rhinoplasty with processed costal cartilage guided by preoperative computed tomography and 3D scanning
Authors: Szychta Pawel
Published: March 2024

Background

Revision rhinoplasty presents unique challenges, particularly in achieving structural integrity and aesthetic harmony. This study explores the efficacy of costal grafts in addressing these challenges, focusing on anatomical corrections and patient outcomes.

Materials and methods

A prospective analysis was conducted on patients undergoing revision rhinoplasty with costal grafts. An algorithmic approach was applied to tailor the surgical technique to individual anatomical needs, documented through pre- and postoperative assessments, including CT imaging and 3D scanning.

Results

A total of 34 patients were included. Significant improvements were noted in nasal structure and function post-surgery. The mean NOSE score improved from 94.47 ± 5.48 preoperatively to 12.59 ± 13.43 postoperatively, and the mean ROE score increased from 18.44 ± 10.02 to 92.65 ± 13.00, indicating substantial enhancement in both nasal airway function and patient satisfaction. The use of costal grafts facilitated effective corrections for a broad spectrum of nasal deformities, with a complication rate of 2.94%.

Conclusions

Costal grafts in revision rhinoplasty offer a versatile and effective solution for complex nasal deformities. The algorithmic approach used in this study enhances repeatability and outcomes, suggesting a promising avenue for achieving desired aesthetic and functional results in revision cases. Further research is warranted to optimize techniques and evaluate long-term outcomes.

Level of evidence

II.