bluuebunny/crossref_metadata_2025 huggingface dataset:
Peramalan Permintaan Dan Pengendalian Persediaan Produk Daging Babi Beku Di PT. XYZ
Authors: Luswiantini Ni Nyoman Dian , Yoga I Wayan Gede Sedana , Triani I Gusti Ayu Lani
Published: December 2023

ZYX is a distributor of frozen pork. Various product types, high product demand, resulting in inventory shortages and order delays. This study aims to classify products based on usage and cost levels using the ABC method, obtaining the best forecasting method from the time series method, obtaining the optimal order quantity using the Economic Order Quantity method, as well as sensitivity analysis of the optimal quantity for classified A products. five types of products are included in class A, namely: pork belly skin on, pork belly skin off, pork leg boneless, pork neck, and pork shoulder. The best demand forecasting results with exponential smoothing method for pork belly skin on, pork belly skin off, and pork shoulder products, as well as the linear trend line model method for pork leg boneless and pork neck. The percentage of savings on total inventory costs is 13 percent to 60 percent. The results of the sensitivity analysis show that the input cost of storage is the most sensitive to changes in the optimal order value. The application of some of these methods can provide sufficient raw materials and avoid shortages of inventory so that there are no delays in orders, and can improve cost efficiency

Keywords : Abc analysis, eoq, sensitivity, inventory, forecasting

XYZ merupakan distributor daging babi beku. Jenis produk beragam, permintaan produk yang tinggi, mengakibatkan terjadinya kekurangan persediaan dan penundaan pesanan. Penelitian ini bertujuan untuk mengklasifikasikan produk berdasarkan tingkat pemakaian dan biaya dengan metode ABC, memperoleh metode peramalan terbaik dari metode time series, memperoleh kuantitas pemesanan optimal dengan metode economic order quantity, serta analisis sensitivitas terhadap kuantitas optimal pada produk terklasifikasi A. Hasil penelitian menunjukkan bahwa 5 jenis produk masuk ke dalam kelas A yaitu: pork belly skin on, pork belly skin off, pork leg boneless, pork neck, dan pork shoulder. Hasil peramalan permintaan terbaik dengan metode exponential smoothing pada produk pork belly skin on, pork belly skin off, dan pork shoulder, serta metode linear trend line model untuk pork leg boneless dan pork neck. Hasil persetase penghematan terhadap total biaya persediaan 13 persen sampai 60 persen. Hasil analisis sensitivitas menunjukkan input biaya simpan paling sensitif terhadap perubahan nilai pemesanan optimal. Penerapan beberapa metode ini dapat, menyediakan bahan baku yang cukup dan tidak terjadinya kekurangan persediaan sehingga tidak terjadinya penundaan pesanan, serta dapat meningkatkan efisiensi biaya.

Kata kunci : Analisis abc, eoq, sensitivitas, persediaan, peramalan
Síntesis de la jurisprudencia casacional sobre empleo público más significativa del segundo periodo del año 2023
Authors: Chaves García José Ramón , Rastrollo Suárez Juan José
Published: December 2023

A lo largo de la presente sección presentamos una síntesis de la jurisprudencia casacional sobre empleo público más significativa durante el segundo período del año 2023.
„Einem Menschen begegnen heißt, von einem Rätsel wachgehalten werden." (E. Levinas) Perspektiven zur Weiterentwicklung des Personzentrierten Ansatzes
Authors: Schmid Peter F.
Published: December 2023

10 Jahre nach dem Tod von Carl Rogers läßt sich ein Resümee ziehen: Was haben uns bald sechs Jahrzehnte des Personzentrierten Ansatzes gebracht? Welche Folgerungen ergeben sich daraus - wissenschaftlich, gesellschaftlich, praktisch? Und wie sehen die Perspektiven für die Zukunft des Personzentrierten Ansatzes aus? In welche Richtung steht eine Weiterentwicklung an?
Es wird die These vertreten, daß dies auf einen wahrhaft personalen und sozialen Ansatz hin geschehen soll, der dann auch zu einem Grundkonsens jener Schulen beitragen kann, die sich einem dialogischen und begegnungsorientierten Verständnis von Psychotherapie verpflichtet wissen und den entsprechenden Paradigmenwechsel in Theorie und Praxis vollziehen. Insofern tritt der Ansatz an, - wie jeder gute Therapeut in einer Therapie - sich selbst überflüssig zu machen. Nicht etwa, weil eine solche „Therapie der Zukunft" (Carl Rogers) bereits Realität wäre; im Gegenteil, die konsequente Verwirklichung des Rogerianischen Paradigmenwechsels steht auch für den Personzentrierten Ansatz selbst erst noch aus.
Client-Centered Family Therapy: Individual and Ecosystemic Issues
Authors: Gaylin Ned L.
Published: December 2023

Conducted within the context of the family, client-centered family therapy incorporates but also transcends dimensions of classic individual client-centered psychotherapy. When client-centered therapy is conducted within the family context its impact and efficaciousness is profoundly enhanced. Rogers' "necessary and sufficient conditions" for psychotherapeutic change are directly transferable to the context of client centered family therapy but require conceptual augmentation which create subtle but portentous new dimensions in the milieu of family therapy.
Pengamatan morfologi β-tcp yang disintesis dari cangkang kerang hijau
Authors: Urrohman Auliya , Eddy  , Permata Setiana Putri Tansza
Published: December 2023

β-Tricalcium Phosphate (β-TCP) is a biomaterial commonly used in dentistry as a bone substitute. β-TCP is a calcium phosphate compound where β-TCP requires a calcium source to be synthesized. The source of calcium could be obtained from green mussel shells because they have high calcium carbonate (CaCO3). The purpose of this study was to determine the effect of sintering temperature on the morphology of β-TCP synthesized from green mussel shells. The method of this research is an exploratory research conducted by knowing the effect of sintering temperature on the morphology of β-TCP synthesized from green mussel shells. The results of the synthesis were tested for characterized with a Scanning Electron Microscope (SEM). In the SEM characterization results, the higher the sintering temperature used in the sample, the more fused and resulting larger particle size. β-TCP with sintering temperature variations of 950℃, 1.000℃, 1.050℃ and 1.100℃ has a morphology consisting of small particles of irregular shape and bonding to each other to form micropores. The conclusion in this study is that the higher the sintering temperature applied, the more the particles coalesce and form larger particles.
Perawatan kaping pulpa indirek disertai restorasi resin komposit pada premolar kedua kanan maksila
Authors: Moniaga Winny , Elline  , Elsa Prahasti Anastasia , Ratnasari Dina
Published: December 2023

Background: Dental caries remains a common condition among people of all ages, as indicated by its impact on the elderly and young people. Proximal caries become more prevalent and eventually dominate the decayed filled surfaces (DFS) score

The current restorative dentistry technique aims to induce remineralization of hypomineralized carious dentine, thus conserving and preserving the vital pulp, it could reduce the need for more invasive endodontic therapy. Unexposed pulp with minor inflammation from traumatic injuries or cavities has a good chance of being repaired, It is predicted that pulp tissue will have a repair capacity following removal of a caries lesion. The goal of indirect pulp therapy is to preserve tooth life by regenerating reparative dentin at the material-pulpal complex, which functions as a biological seal.Case report:  A 26-year-old male patient presented to the endodontic and conservative dentistry department complaining of discomfort caused by thermal stimulation on the permanent maxillary right premolar and molar. The radiograph examinations revealed no radiolucencies in the periapical region and an interproximal caries lesion on the maxillary right second premolar and first molar with a deep distal caries lesion on the secondary premolar, close to the pulp. Thermal pulp vitality testing confirmed the sensitivity of the pulp. The treatment approach was devised to maintain the vitality of the pulp. Infected dentin was removed and lined with a calcium silicate-based substance, followed by the placement of composite resin as a final restoration.Conclusion: Using light-cured calcium silicate material showed advantages in clinical performance as an indirect pulp capping agent.
Perbandingan penilaian senyum yang estetis menggunakan konsep Golden Proportion, Recurring Esthetic Dental (RED), dan Golden Percentage
Authors: Ayu Ratih Utari Mayun I Gusti
Published: December 2023

Background : Various studies have shown that facial aesthetics is determine by the harmonization and aesthetic teeth. One important aspect of aesthetic dentistry focuses on improving the appearance especially the rehabilitation of the maxillary anterior teeth. There are several concepts in aesthetic dentistry that can be use as a guideline in determining the shape and size of the maxillary anterior teeth to get the harmonization of aesthetic smile and function of the teeth, such as  Golden Proportion, Reccuring Esthetic Dental (RED) dan Golden Percentage. Golden Proportion was the first and most often used as a guideline in determining the proportion of the frontal width maxillary anterior teeth. But it has some weaknesses, therefor an alternative concept was developed, such as Recurring Esthetic Dental (RED) and Golden Percentage. Recurring Esthetic Dental (RED) is the proportion of the successive of the frontal width of the maxillary anterior teeth remaining constant, when progressing distally from the midline. While Golden Percentage is the percentage proportion of the frontal width of maxillary anterior teeth should be 10%, 15%, 25%, 25%, 15%, 10%. Summary : The proportion of the width of the maxillary anterior teeth are unsuitable with the concept of the Golden Proportion, Recurring Esthetic Dental (RED) and Golden Percentage. But the concept of Golden Percentage assessed more applicable in its use.
Gambaran kebutuhan perawatan ortodonti berdasarkan indikator kebutuhan perawatan ortodonti (ikpo) (Kajian Pada Remaja Usia 15 – 17 tahun di SMA GITA KIRTTI 3)
Authors: Nofrizal Riko , Auliashinta Annisa
Published: December 2023

Background: Adolescent are often aware of their physical performance and they will find solutions in order to achieve the ideal appearance. The ideal appearance especially on the teeth is an important factor in increasing facial attractiveness which is important in social interactions. There are several important factors that affect the appearance of teeth, including color, shape, and position of the teeth especially the anterior teeth and if there is trauma to the anterior teeth that can be overcome with orthodontic treatment. There is an indicator that can be used to determine the level of need for orthodontic treatment. Objective: The purpose of this study was to determine the orthodontic treatment needs of Gita Kirtti 3 High School students based on the Orthodontic Care Needs Indicator (IKPO). in this study there were 51 subjects aged 15-17 years who were determined as research subject. The subject then filled out the IKPO questionnaire that had been given. Results: The results of this study showed that based on the IKPO score, 45 subjects (88.2%) need orthodontic treatment and 6 subjects (11.8%) did not need orthodontic treatment. Based on the distribution of gender, both men and women have more scores who need orthodontic treatment than those who do not need orthodontic treatment. Conclusion: From this study, it can be concluded that the number of orthodontic treatment needs in Gita Kirtti 3 high school students is high, this shows that adolescent knowledge and awareness of orthodontic treatment is good enough so that the level of willingness to undergo orthodontic treatment is so high.
Hubungan antara kebiasaan parafungsional dan gangguan temporomandibula pada anak usia remaja (Kajian terbatas di Jakarta)
Authors: Budiman Michael , Damayanti Marpaung Carolina
Published: December 2023

Background: Temporomandibular disorders (TMD) are musculoskeletal disorders involving the temporomandibular joints, masticatory muscles, and associated structures. The etiology of temporomandibular disorders is complex and multifactorial. Parafunctional activities are considered main factors that are associated with TMD. Objective: To examine the association between parafunctional habits and temporomandibular disorders in adolescence. Methods: An analytical observational study with a cross-sectional design was carried out on 443 children (236 men and 207 women) aged 12-13 years. The data obtained consisted of univariate and bivariate data on parafunctional habits and temporomandibular disorders based on the results of the adolescent’s questionnaire V.2. The data were analyzed by Chi-square test. Result: Bivariate analysis showed a significant association (p <0.05) between sleep clenching and awake clenching with temporomandibular pain (p = 0.047 and p = 0.001). A significant association was found between sleep grinding and biting the lips / cheeks habits with joint sounds (click / pop) (p = 0.045 and p = 0.020). Analysis of the association between sleep grinding and sleep clenching with limited jaw motion also showed a significant association (p = 0.014 and p = 0.004). Conclusion:  There are associations between clenching and temporomandibular pain; sleep grinding and biting the lips / cheeks with joint sounds (click / pop); and between sleep bruxism and limited jaw motion.
DIMENSÕES ANDRAGÓGICAS NA FORMAÇÃO DOS MESTRANDOS DE ENSINO NOS SERVIÇOS DE SAÚDE: APRENDIZADOS PARA A DOCÊNCIA
Authors: Lopes Soares Geórgia Karine , De Vasconcelos André Morais Duarte , De Souza Fernanda Araújo , De Sousa Francisco Alain Peixoto , De Almeida Iana Maria Dinis , Maia Isabelly Duarte , Volpi Maria Gleice Carneiro Teixeira , Da  Sillva Neta Maria de Lourdes
Published: December 2023

educação é a base de todo processo de transformação do sujeito. Nos diversos estágios, desde a educação religiosa, quando era ministrada pelos jesuítas, passando pela educação prática na época da revolução industrial, até os dias atuais, voltada para a profissionalização do sujeito. Este artigo trata-se de um estudo descritivo do tipo relato de experiência, realizado por estudantes de um curso de mestrado, sobre teorias e princípios de aprendizagem do adulto, usando como norteadores os princípios da andragogia. Tem-se como objetivo geral relatar a vivência dos estudantes de um curso de mestrado profissional em ensino na saúde, suas formas de conhecimento sobre o processo de ensino e aprendizagem com seus desafios, além de trazer para si novos conceitos e atividades para desenvolver o conhecimento centrado na autonomia dos estudantes. Este estudo possibilitou a aplicação prática dos conceitos de andragogia com abordagens inovadoras a fim de atender às exigências de um mundo em constante transformação, aproximando teoria e prática no processo de formação de novos multiplicadores desse conhecimento.
A GESTÃO DA EDUCAÇÃO NO ESTADO DE GOIÁS, 2019-2022, CORONELISMO E NEOLIBERALISMO
Authors: Das Chagas Filho João Roque , Rosa da Silva Viviane , Mendanha de Oliveira Túlio Fernando
Published: December 2023

Neste trabalho buscamos uma tentativa de desvelar as características dos grupos que exercem a hegemonia no campo de poder goiano, bem como a construção dos habitus políticos destes grupos como forma de perpetuação no poder, da manutenção do status quo e as implicações deste modo de fazer política na atual gestão da Secretaria de Educação do Estado de Goiás (SEDUC). Tentamos também reconhecer como os desdobramentos da política neoliberal se coloca nesse modo de operar político. Para levantamento de algumas informações que utilizamos aqui com relação a temática apresentada, acessamos matérias publicadas em sites oficiais do Governo de Goiás, assim como nas outras mídias, sites e jornais. Como aporte teórico-metodológico, nos fundamentamos em estudiosos como Pierre Bourdieu, Pierre Dardot, Christian Laval e Michael Apple, no sentido de que estes autores se dedicam em analisar como as relações de poder se colocam dentro da sociedade neoliberal. Para uma melhor compreensão do cenário atual faremos um breve apanhado histórico com o intuito de conhecer a estruturação política, econômica e cultural do Estado de Goiás. Desta forma o presente trabalho está organizado em três momentos. O primeiro é um breve relato de como se constitui a relação de poder no Estado historicamente, assim como seus desdobramentos nas políticas públicas e na educação. No segundo, abordamos a atual gestão frente a Seduc e a implementação do “Novo Ensino Médio” no Estado de Goiás, e por fim, apresentamos reflexões a respeito da postura política da atual gestão da Secretaria de Educação do Estado de Goás.
Ascent and emplacement controls of mafic magmas in the mid crust − evidence from 3D modelling of basic bodies of the Koperberg Suite, Namaqualand
Authors: Bester A. , Kisters A.
Published: December 2023

The 3D modelling of basic bodies of the Koperberg Suite (1060 to 1030 Ma) and their wall rocks from Narrap Mine illustrates the distribution, geometries and, by implication, processes that determined the ascent and emplacement of the mantle-derived mafic magmas into the partially-molten, mid-crustal granite-gneiss sequence of the Okiep Copper District in Namaqualand. The lens-like, discontinuous geometry of basic bodies suggests the transfer of the mafic magmas as self-contained, buoyancy-driven hydrofractures. The presence of both shallowly-dipping, foliation-parallel sills and subvertical lenses in zones of steep foliation development, so-called steep structures, indicates an emplacement of the mafic magmas under low deviatoric stresses and irrespective of the regional stress field. Instead, the emplacement of the mafic magmas parallel to pre-existing anisotropies (tectonic fabrics or lithological contacts) highlights those differences in tensile strength and fracture toughness parallel to or across anisotropies determined the propagation of the magmas. This also accounts for the common occurrence of basic bodies in steep structures in which the vertical gneissosity promoted the buoyancy-driven ascent of the mafic magmas.

On a regional scale, the mechanical stratification of the subhorizontal, sheet-like granite gneisses and interlayered metasediments exerted important controls on the ascent of Koperberg Suite magmas. The preferential emplacement of basic bodies in schist and gneiss units suggests that the lower rigidity of the ductile wall rocks facilitated magma emplacement through a combination of viscous wall-rock deformation and fracture blunting that led to the arrest of the magma-filled hydrofractures. Multiple intrusive relationships of successively emplaced magma batches suggest that later magmas reutilised earlier established magma pathways, particularly in steep structures. High-rigidity lithologies, such as the massive Springbok Quartzite, in contrast, only allowed for smaller fracture apertures and limited dilation, resulting in the pinching of basic bodies and rather stringer-like geometries. It is conceivable that the higher fracture toughness of the quartzite may also have prevented propagation of the mafic magmas through the Springbok Quartzite and, instead, led to the ponding of basic bodies below the metasediments.

The geometry and structural and lithological controls of basic bodies at Narrap Mine are similar to Koperberg Suite intrusions documented from many of the other mine workings in the Okiep Copper District. This suggests similar underlying emplacement controls of the cupriferous rocks, which can be extrapolated on a regional scale and that may guide exploration.
ANALISIS KALIMAT EFEKTIF PADA SOAL CERITA BIDANG STUDI MATEMATIKA DI SMK
Authors: Fitriah Lailatul , Eka savitri Devandra , Hoang Van Anh Huynh
Published: December 2023

ABSTRAK: Soal cerita matematika merupakan salah satu tipe soal yang digunakan untuk melatih kemampuan berhitung siswa  dan membaca pemahaman. Namun banyak kesalahan dalam penulisan soal cerita matematika sehingga soal membingungkan dan tidak mudah dipahami, yang biasanya disebabkan oleh adanya kata yang berlebih. Penelitian ini menggunakan metode deskriptif, data dianalisis dengan mendeskripsikan ketidakefektifan kalimat. Sumber data merupakan soal cerita matematika yang terdapat dalam soal Try out SMK tahun ajaran 2020-2021. Hasil penelitian ini memperlihatkan bahwa, 1. Ketidakefektifan kalimat disebabkan  karena adanya penggunaan kata yang berlebihan atau pemborosan kata. 2. Ketidakefektifan kalimat yang menyebabkan ambiguitas atau bermakna ganda.
KATA KUNCI: Soal Cerita; Matematika; kalimat Efektif; Ambiguitas
 
ANALYSIS OF EFFECTIVE SENTENCES ON STORY QUESTIONS IN THE FIELD OF MATHEMATICS STUDY IN VOCATIONAL SCHOOL
 
ABSTRACT: Mathematical story questions are one type of problem that is used to train students' numeracy skills and reading comprehension. However, there are many mistakes in writing math story problems so that the problems are confusing and not easy to understand, which is usually caused by the presence of excess words. This study used a descriptive method, the data were analyzed by describing the ineffectiveness of the sentence. The data source is a math story problem contained in the Vocational High School try out questions for the 2020-2021 school year. The results of this study indicate that, 1. The ineffectiveness of sentences is caused by excessive use of words or waste of words. 2. Ineffective sentences that cause ambiguity or have multiple meanings.
KEYWORDS: Problem Stories; Mathematics; Effective Sentences; Ambiguity
DE DENÚNCIAS DE VIOLÊNCIA SEXUAL AO #METOO
Authors: De Souza Paes Paula , Colussi Juliana
Published: December 2023

RESUMO – O objetivo principal deste artigo é identificar os elementos combativos que caracterizam as práticas profissionais das jornalistas norte-americanas Jodi Kantor e Megan Twohey, centrando-se nos trabalhos investigativos sobre violência sexual contra mulheres publicados no New York Times. Para o estudo de caso, realizou-se uma análise qualitativa do livro Ela disse: os bastidores da reportagem que impulsionou o #MeToo e de reportagens de autoria de ambas as jornalistas, pelas quais receberam o Prêmio Pulitzer de 2018. Os resultados indicam que as jornalistas realizaram uma investigação exaustiva, caracterizada por legitimar falas femininas, ao visibilizar as denúncias de mulheres vítimas de assédio sexual. Também é evidente o comprometimento das jornalistas em confrontar os agressores e revelar os fatos silenciados por figuras poderosas, como Donald Trump.
ABSTRACT – The main objective of this paper is to identify the combative elements in the professional practices of American journalists Jodi Kantor and Megan Twohey, focusing on investigative reports on sexual violence against women published in the New York Times. For this case study, a qualitative analysis was carried out on the book She Said: Breaking the Sexual Harassment Story That Helped Ignite a Movement and on the 2018 Pulitzer Prize-winning reports authored by these same journalists. The results show that these journalists conducted a thorough investigation, legitimizing female speech by bringing to light the complaints of women victims of sexual harassment. The commitment these journalists have to confronting aggressors and uncovering facts that are concealed by powerful figures, such as Donald Trump, is also evident.
RESUMEN – El objetivo principal de este artículo es identificar los elementos combativos que caracterizan las prácticas profesionales de las periodistas estadounidenses Jodi Kantor y Megan Twohey, enfocándose en los trabajos de investigación sobre violencia sexual contra mujeres publicados en New York Times. Para el caso de estudio, se realizó un análisis cualitativo del libro She said: la investigación periodística que destapó los abusos de Harvey Weinstein e impulsó el movimiento #MeToo y de reportajes de autoría de ambas periodistas, por los cuales recibieron el premio Pulitzer de 2018. Los resultados indican que las periodistas realizaron una investigación exhaustiva, caracterizada por legitimar las hablas femeninas al visibilizar las denuncias de mujeres víctimas de acoso sexual. También es evidente el compromiso de las periodistas al confrontar a los agresores y revelar los hechos que estaban silenciados por figuras poderosas, como Donald Trump.
Palavras-chave: Jornalismo combativo. Jornalismo investigativo. Assédio sexual. #MeToo. New York Times.
PARA UMA PERSPECTIVA CONTRA-HEGEMÔNICA DOS DIREITOS HUMANOS DE ADOLESCENTES: REFLEXÕES A PARTIR DA DOUTRINA DE PROTEÇÃO INTEGRAL E DO SISTEMA SOCIOEDUCATIVO BRASILEIRO
Authors: Bruzaca Ruan Didier , Costa Greycianne Mendes , Guimarães Sâmella Conceição Vale Silva
Published: December 2023

O presente artigo científico aborda os direitos humanos do adolescente, especificamente o autor de ato infracional, trazendo para reflexão a proteção integral e o sistema socioeducativo no Brasil. Neste aspecto, leva-se consideração que, apesar dos dispositivos legais que dispõem acerca da proteção integral no tratamento dispensado a adolescentes em cumprimento de medida socioeducativa, percebe-se a manutenção do cenário de violações de direitos característico da sociedade brasileira. Assim sendo, encara-se como problema o questionamento da efetividade de direitos humanos de adolescentes no sistema socioeducativo no contexto legislativo e do sistema socioeducativo brasileiro. Objetiva, de forma geral, destacar a efetividade de direitos humanos de adolescentes no sistema socioeducativo no contexto brasileiro e, especificamente, discutir os fundamentos jurídicos da proteção integral no sistema socioeducativo e seu panorama, bem como abordar a efetividade dos direitos humanos de adolescentes segundo a abordagem contra-hegemônica. A proposta metodológica utilizada foi a pesquisa básica, exploratória e bibliográfica, com abordagem qualitativa.
Perfil clínico e epidemiológico de indivíduos submetidos à profilaxia da infecção pelo vírus HIV no interior da Amazônia
Authors: Santos Alexandre Gomes dos , Coelho Aldine Lima Cecília , Silva Ícaro Breno Rodrigues da , Souza Juarez de
Published: December 2023

Objetivo: Descrever o perfil de pacientes que buscaram as profilaxias para o vírus da imunodeficiência humana em um Centro de Testagem e Aconselhamento. Métodos: Trata-se de um estudo do tipo observacional, transversal e descritivo de carácter retrospectivo, baseado na análise das fichas de acolhimento dos pacientes maiores de 18 anos que utilizaram das profilaxias pré e pós exposição (PrEP e PEP), durante o ano de 2022. Foi utilizada estatística descritiva e inferencial, adotando o valor de P<0,05 como critério de análise da significância estatística. Resultados: Durante o período analisado, foram atendidos 337 pacientes, sendo cerca de 87% dos pacientes com a PEP e os outros 13% com  a PrEP. Um número considerável de informações omitida das sugerem subnotificação. Apenas 7 das 20 variáveis analisadas foram consideradas significativas estatisticamente ao se comparar com a variável “Modalidade de Profilaxia”. Conclusão: Embora o serviço analisado seja de grande importância na prevenção da infecção no interior da Amazônia, muitos desafios ainda persistem, o que demonstra a necessidade de investir em apoio técnico e social no intuito de melhorar os registros de informações e fortalecer a relação profissional-paciente.
Transtorno bipolar tipo II: a relação entre nefrite intersticial e o uso do lítio
Authors: Araújo Amanda Fernandes Borges de , Silva Leandro Soares Macedo , Ribeiro Lylian Machado Palmiere , Alencar Thalyta dos Santos , Bernardes Filho Walter José , Silva Junior George Martins Ney da
Published: December 2023

Objetivo: Relatar o caso de uma paciente diagnosticada com nefrite intersticial aguda, secundária ao uso do Lítio no tratamento de Transtorno Bipolar (TB), revisando cientificamente a correlação entre o medicamento e as nefropatias. Detalhamento de caso: Paciente do sexo feminino, 24 anos, atendida em consultório particular relatando ideias suicidas, com diagnóstico de síndrome disfórica grave. Foram iniciadas sessões de psicoterapia cognitivo-comportamental, bem como seu tratamento medicamentoso, seguido por diversas crises e tentativas frustradas de introdução de Lítio como uma opção viável. Entretanto, após uma década de tratamento, a paciente concordou em iniciar seu uso. Oito anos depois, foi diagnosticada nefrite intersticial aguda, secundária ao uso do Lítio, substituindo-o por Carbamazepina. A paciente continuou seu tratamento por mais quatro anos, até que foi encaminhada para outro profissional, em uma localidade distinta. Considerações finais: O TB é um distúrbio psiquiátrico complexo, com alterações drásticas de humor e comportamentais, sendo o Lítio o seu tratamento de primeira linha. Entretanto, essa medicação é responsável por desenvolver doença renal progressiva em uma porcentagem significativa dos pacientes, sendo que alguns deles desenvolvem quadros graves, como nefrite intersticial.
Avaliação do nível de conhecimento em primeiros socorros pelos acadêmicos de medicina da região do Alto Tietê
Authors: Grigoletto Karen Kofity , Galvão Gustavo Ghirelli Nunes , Carvalho Victoria Sideri de , Rodrigues Gregory Carvalho , Lima Maria Fernanda Marques , Nunez Pedro Rogatis , Menegidio Fabiano Bezerra , Sueoka Júnia Shizue
Published: December 2023

Objetivo: Analisar o nível de conhecimento dos estudantes de medicina do primeiro e quarto ano da Faculdade de Medicina da região do Alto Tietê sobre o tema primeiros socorros. Métodos: Foi realizado um estudo transversal com a aplicação de um questionário online quali-quantitativo para analisar o nível de conhecimento dos estudantes, maiores de idade e de ambos os sexos, acerca das técnicas de primeiros socorros e das situações de emergência em que se sentem mais confortáveis para intervir. Foram elaboradas 37 questões de múltipla escolha abordando temas como: presença de sinais vitais, convulsões, entorse, suspeita de fratura da coluna cervical e imobilização, massagem cardíaca, distensão muscular, fraturas, desmaio e choque. Resultados: Durante a coleta de dados, foram obtidas 83 respostas. Entre as respostas fornecidas, observou-se que 97,6% dos estudantes concordavam com a necessidade do conhecimento das técnicas de primeiros socorros para evitar mortes e prevenir sequelas durante sua prática. Conclusão: O estudo evidencia a importância das intervenções e práticas educativas sobre primeiros socorros na formação dos estudantes de medicina. Esses conhecimentos serão essenciais para suas futuras práticas clínicas.
Associação entre hipotireoidismo e depressão clínica
Authors: Santis Letícia Almeida de , Cremonezi Isabela Marangoni , Vidal Luiza , Santos Carla Mikaela Brandão , Sarmento Kellen , Papes Kéli Daiane , Silva Mariana Arruda da , Ruschel Laurence Vezzani , Mourão Nathália Lanes , Silveira Myrna Maria Costa de Melo
Published: December 2023

Objetivo: Avaliar a associação entre hipotireoidismo e depressão clínica, explorando a prevalência e a gravidade dos sintomas depressivos em pacientes com hipotireoidismo e buscando entender os mecanismos fisiopatológicos subjacentes a essa associação. Métodos: Revisão Integrativa, através da base de dados PubMed com os termos MeSH "hypothyroidism", "depressive disorder" e "depression", em combinação com os operadores booleanos "OR" e "AND". A busca inicial resultou em 330 artigos, dos quais 16 foram selecionados para análise, com base em critérios de inclusão e exclusão rigorosos. Resultados: Evidencia-se uma interação significativa entre hormônios tireoidianos e funções neuronais. Estudos revelam que adultos com hipotireoidismo subclínico apresentam um risco aproximadamente 2,5 vezes maior de desenvolver sintomas depressivos, com uma prevalência mais acentuada na população geriátrica. No entanto, estudos prospectivos de coorte que investigam essa correlação exibem resultados divergentes, possivelmente devido a variáveis como idade, gênero, critérios de referência para o hormônio estimulante da tireoide e intensidade dos sintomas depressivos iniciais. Considerações finais: Investigações adicionais são necessárias para elucidar de forma mais precisa a inter-relação entre hipotireoidismo e depressão. Variáveis como idade, gênero e gravidade do hipotireoidismo parecem influenciar significativamente a interação entre essas duas patologias.
Earth’s large lakes are shrinking
Authors: Yao Fangfang , Livneh Ben , Rajagopalan Balaji
Published: December 2023

Lakes play a crucial role in providing freshwater and support many essential ecosystem services. In a new study, we found significant water losses in 53% of large lakes on Earth in the past 28 years. These losses are attributed to human consumption, warming climate, and sedimentation. Two billion people reside in areas where lakes are drying, underscoring the urgent need for management solutions.
Impact of timing of decompressive craniectomy on outcomes in pediatric traumatic brain injury
Authors: Nagy Laszlo , Morgan Ryan D. , Collins Reagan A. , Kharbat Abdurrahman F. , Garza John , Belirgen Muhittin
Published: December 2023

Background:

Decompressive craniectomy (DC) can be utilized in the management of severe traumatic brain injury (TBI). It remains unclear if timing of DC affects pediatric patient outcomes. Further, the literature is limited in the risk assessment and prevention of complications that can occur post DC.

Methods:

This is a retrospective review over a 10-year period across two medical centers of patients ages 1 month–18 years who underwent DC for TBI. Patients were stratified as acute (<24 h) and subacute (>24 h) based on timing to DC. Primary outcomes were Glasgow outcome scale (GOS) at discharge and 6-month follow-up as well as complication rates.

Results:

A total of 47 patients fit the inclusion criteria: 26 (55.3%) were male with a mean age of 7.87 ± 5.87 years. Overall, mortality was 31.9% (n = 15). When evaluating timing to DC, 36 (76.6%) patients were acute, and 11 (23.4%) were subacute. Acute DC patients presented with a lower Glasgow coma scale (5.02 ± 2.97) compared to subacute (8.45 ± 4.91) (P = 0.030). Timing of DC was not associated with GOS at discharge (P = 0.938), 3-month follow-up (P = 0.225), 6-month follow-up (P = 0.074), or complication rate (P = 0.505). The rate of posttraumatic hydrocephalus following DC for both groups was 6.4% (n = 3).

Conclusion:

Although patients selected for the early DC had more severe injuries at presentation, there was no difference in outcomes. The optimal timing of DC requires a multifactorial approach considered on a case-by-case basis.
Factors determining the requirement of surgical intervention and prognosis in cases of traumatic bifrontal contusions: A prospective observational study
Authors: Ratan Raj , Mohindra Sandeep , Tripathi Manjul , Singla Raghav , Chauhan Rajeev
Published: December 2023

Background:

Traumatic brain injury, being a notorious cause of mortality and morbidity across the globe, presents with a variety of lesions. One of the distinct patterns of injury is characterized by contusions of both frontal lobes, labeled “traumatic bifrontal contusions” (TBCs). TBC is often associated with the presence of significant edema and mass effect leading to rapid clinical deterioration after a usually benign presentation at the time of first evaluation. Formulating a management plan in a patient with TBC is often more difficult than in a patient with a major intracranial hematoma.

Methods:

A prospective observational study with aims and objectives to identify predictors of an unfavorable outcome, analysis of the evolution of TBC, evaluation of the specific indications for surgery, and determination of the prognosis. All head trauma patients harboring bifrontal contusions were included in the study. Patients with other associated operable injuries involving blunt trauma abdomen and orthopedic injuries, counter-coupe injuries, and obvious open fractures noted over calvaria were excluded from the study. Glasgow coma scale (GCS) was recorded during the first assessment, followed by non-contrast computerized tomography (NCCT) Head.

Results:

A total of 53 patients satisfying inclusion and exclusion criteria were included in the study. The average GCS score recorded before surgical intervention was 9. The mean and median best motor response noted was M5. The interval from the time of injury to the first NCCT of the brain at the study hospital ranged from 3 h to 163 h, averaging 17.66 h. The median category w.r.t Marshall’s CT classification observed was “Diffuse Injury IV.” The volume of the contusions in each scan was estimated, and the average anterior cranial fossa volume observed was 125 mL. “Upfront surgery” (“Bifrontal decompressive craniectomy” or “unilateral Fronto-Temporo-Parietal [FTP] decompressive hemicraniectomy”) was carried out on the day of admission based on the findings on the first NCCT brain. About 49% of patients at presentation needed surgical intervention as per existing protocols. The duration of observation for patients who were initially observed but eventually had to undergo surgery ranged from 1 to 5 days, with an average observation period of 2 days. The duration of observation in those who did not subsequently need surgery ranged from 7 to 10 days, with an average duration of 9 days.

Conclusion:

What leads to the poorly predictable, delayed, and rapid deterioration that sets TBCs apart from other traumatic brain injuries is still unclear. Our study finds that having a low threshold for repeat CT imaging of the patient led to earlier identification of progression, and a low threshold for surgical intervention led to favorable outcomes.
Lipotranferences in post neurosurgical esthetic defects
Authors: Demichelis Mickaela Del Rosario Echavarría , Barrera Augusto , Campero Alvaro , Sufianov Albert , Ramírez Manuel De Jesus Encarnación , Nurmukhametov Renat , Montemurro Nicola , Castillo-Rangel Carlos , Rosario Andreina Rosario , Baldoncini Matias
Published: December 2023

Background:

There are numerous procedures in which, beyond adequate manipulation of the temporalis muscle and cranial closure, patients may present bone and muscle defects due to atrophy and consequent facial asymmetry, causing psychological discomfort and functional deterioration. The objective of our work is to combine the knowledge of plastic surgery and apply it to cranial reconstructions with fat transfers in post-neurosurgical patients, analyzing its results.

Methods:

During the year 2022, 45 fat transfer procedures were performed for the correction of craniofacial defects, of which 29 were female and 16 were male. All had a surgical history of pterional craniotomies and their variants, orbitozygomatic and transzygomatic approaches, with the consequent volume deficit.

Results:

The procedure was performed on an outpatient basis, with local anesthesia, and in an average time of 30–40 min. The lower hemiabdominal region was used as the donor area, processing the fat using the decantation technique and injecting it into the receptor area at the craniofacial level. The patients tolerated the procedure adequately without intraoperative complications or superadded events.

Conclusion:

Fat transfer is a minimally invasive, effective, and cost-effective technique that plastic surgery offers us to implement in post-neurosurgical patients, as it achieves natural results that stand the test of time.
Realisation, elision and intrusion of /h/ in French learners of English
Authors: CAPLIEZ Marc
Published: December 2023

As the phonological systems of English and French diverge both at the segmental level and at the prosodic level, French learners encounter difficulties with English pronunciation. One example is the glottal fricative /h/ since it is absent from the French phonemic inventory–with the exception of the onomatopoeia “haha” to express laughter. Following studies by Exare (2017) and Kamiyama et al. (2011), this paper aims to provide further empirical evidence of the realisation, elision, and intrusion of /h/ in French speakers’ English productions. The learners were university students who did not major in English. The participants were given three tasks, i.e., word reading, sentence reading, and spontaneous speech. Auditory analyses were then carried out by the researcher. Results show four speaker-profiles: (1) /h/ is absent altogether; (2) /h/ is accurately realised; (3) /h/ is accurately realised in addition to regular occurrences of intrusive /h/; (4) only intrusive /h/ occurs. Although the speaking task has an influence on intra-speaker variability, intra-speaker consistency has been observed, with participants belonging to one of the above learner-profiles. Also of interest were the differences between men and women. These results suggest that different teaching strategies should be established to better suit the needs of the different profiles.
On analytical corrections for restraints in absolute binding free energy calculations
Authors: Boresch Stefan
Published: December 2023

Alchemical absolute binding free energy simulations require an intermediate state at which the ligand is held solely by restraints in a position and orientation resembling the bound state. One possible choice consists of one distance, two angle and three dihedral angle restraints. Here, I demonstrate that in practically all cases, the analytical correction derived under the rigid rotator harmonic oscillator approximation is sufficient to account for the free energy of the restraint.
On the Valorisation of Chitin-Derived Furans by Ball Milling.
Authors: Mattioli Renan , Santos Camila , De Souza Bruna , Branco Pedro , Bolt Robert , Raby-Buck Sarah , Cabral Tadeu , Tormena Claúdio , Browne Duncan , Pastre Julio
Published: December 2023

Aromatic compounds containing nitrogen atoms in their structure are currently obtained from non-renewable sources with the incorporation of nitrogen from ammonia, which is industrially produced by the highly energy demanding Haber process. To minimize the carbon footprint of nitrogen containing chemicals and drive the production of nitrogenated aromatic compounds in a Haber-independent manner, the use of furans derived from chitin has become an affordable and promising source for nitrogen fixation in compounds with high added-value. Herein, we address the challenge of using two chitin-derived furans, 3-acetamido-5-acetylfuran (3A5AF) and 3-acetamido-5-furfural aldehyde (3A5F), to favor the formation of exo Diels–Alder adducts and 4-acetylaminophthalimides using Mechanochemistry, as a more sustainable and cleaner synthesis compared to the classical methods in solution-phase. The Mechanochemistry activation is explored through the synthesis of novel 7-oxa-norbornene backbones and it showed an improvement in both yield and exo:endo selectivity when compared to solution-phase, with yields reaching up to 77% and selectivity >19:1. We also investigated the use of a less toxic and commercially available hydrazine in order to promote the synthesis of 4-acetylaminophthalimides from 3A5F in yields ranging 20–79%.
Studies on circular dichroism behaviors of aggregated poly(1,4-phenylene)s with head-to-tail regioregularity
Authors: Tanaka Rikuya , Yamaoka Seiha , Ikeda Shuichi , Okano Kentaro , Horie Masaki , Minami Hideto , Suzuki Nozomu , Mori Atsunori
Published: December 2023

Circular dichroism (CD) studies on poly(1,4-phenylene)s bearing a chiral side chain in the aggregated conditions were carried out. Little CD was observed in a solution form, while addition of a poor solvent into the polyphenylene solution induced aggregation and a strong CD was observed, accordingly. Applying the controlled degree of polymerization (DP) of poly(1,4-phenylene) in the use of bidentate diphosphine Chiraphos as a ligand for the nickel catalyst, the relationship of DP with CD strength was studied to reveal to show the highest CD at the DP = 84 (gabs = ca. 2 x 10–2). It was also found that the related aggregation was observed in good solvent 1,2-dichloroethane upon standing the solution at 4 °C for 3–23 days to observe gabs = ca. 10–1. Studies on the substituent effect of poly(1,4-phenylene) suggested that CD behaviors were dependent on the type of non-chiral substituent on the aromatic ring as well as the side-chain chirality.
A Bimolecular Homolytic Substitution-Enabled Platform for Multicomponent Cross-Coupling of Unactivated Alkenes
Authors: Cong Fei , Sun Guo-Quan , Ye Si-Han , Hu Rui , Rao Weidong , Koh Ming Joo
Published: December 2023

The construction of C(sp3)-C(sp3) bonds remains one of the most difficult challenges in cross-coupling chemistry. Here, we report a photoredox/nickel dual catalytic approach that enables the simultaneous formation of two C(sp3)-C(sp3) linkages via trimolecular cross-coupling of alkenes with alkyl halides and hypervalent iodine-based reagents. The reaction harnesses a bimolecular homolytic substitution (SH2) mechanism and chemoselective halogen-atom transfer (XAT) to orchestrate the regioselective addition of electrophilic and nucleophilic alkyl radicals across unactivated alkenes without the need for a directing auxiliary. Utility is highlighted through late-stage (fluoro)alkylation and (trideutero)methylation of C=C bonds bearing different substitution patterns, offering straightforward access to drug-like molecules comprising sp3-hybridized carbon scaffolds.
Spin-Forbidden Formation of Amide Molecules in the Interstellar Medium
Authors: Mirzanejad Amir , Varganov Sergey
Published: December 2023

In this study, two-state spin-forbidden mechanisms are proposed for the barrierless formation of amide isomers in the C2H5NO family of molecules. This family belongs to the first level of complexity among the molecules with peptide bond that are precursors to proteins, which are building blocks of life, and therefore are highly relevant to astrochemistry and astrobiology. Our density functional theory study demonstrates the significance of spin-forbidden pathways in the formation of acetamide (CH3CONH2), N-methyl-formamide (CH3NHCHO), and acetimidic acid (CH3COHNH) from the acetaldehyde, imidogen, formamide, and methylene reactants. Considering the rate constants of analogous reactions in the interstellar medium (ISM), we anticipate that the detected abundances of acetamide and N-methyl-formamide in the Sagittarius B2 North region can be rationalized by the suggested formation pathways. The proposed mechanism also predicts the synthesis of acetimidic acid, motivating future observational efforts to identify this molecule in the ISM.