bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S18 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S18. Univariate Cox regression results for only primary tumor samples. Covariates found to be significant in Univariate Cox regressions for (A) OS and (B) PFS outcomes. Results are shown for main text Figure 5 if analysis restricted to only primary tumor samples (n = 69). Hazard ratio estimates are colored by feature category.
Figure S17 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S17. Outcome variable distributions. Histograms of the two outcome variables used in our analysis (A) OS, in months, and (B) PFS, in months. For predictive modeling, both outcome variables are split at their respective medians into high and low categories to create a binary prediction task.
Figure S16 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S16. Survival curves. Kaplan-Meier survival curves for (A) survival and (B) recurrence outcomes.
Figure S15 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S15. Cell type region size distributions. (A) The proportion of cells of each type found within a region of equal or larger size, displayed with a logarithmic x-axis. (B) The log-log complementary cumulative distribution function of cell type region sizes aggregated across all connected regions in all samples included in the final analysis.
Figure S3 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S3. In vitro tests of virus thermostability.
Figure S12 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S12. Cell type counts across all 83 samples. Counts of each cell type across all identified cells.
Supplementary Table 2 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Table 2. Known Cancer-testis antigen genes used in this study.
Supplementary Table 1 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Table 1. A summary of the clinical trial datasets used in this study.
Supplementary Figure 6 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 6. Two-dimensional density plots showing the correlation between Ecotyper CD8 T cell S3 state with T cell exhaustion (a) and T effector signatures (b).
Figure S7 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Authors: Georgiev Peter , Han SeongJun , Huang Amy Y. , Nguyen Thao H. , Drijvers Jefte M. , Creasey Hannah , Pereira Joseph A. , Yao Cong-Hui , Park Joon Seok , Conway Thomas S. , Fung Megan E. , Liang Dan , Peluso Michael , Joshi Shakchhi , Rowe Jared H. , Miller Brian C. , Freeman Gordon J. , Sharpe Arlene H. , Haigis Marcia C. , Ringel Alison E.
Published: November 2024

Supplemental Figure 7
Figure S6 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Authors: Georgiev Peter , Han SeongJun , Huang Amy Y. , Nguyen Thao H. , Drijvers Jefte M. , Creasey Hannah , Pereira Joseph A. , Yao Cong-Hui , Park Joon Seok , Conway Thomas S. , Fung Megan E. , Liang Dan , Peluso Michael , Joshi Shakchhi , Rowe Jared H. , Miller Brian C. , Freeman Gordon J. , Sharpe Arlene H. , Haigis Marcia C. , Ringel Alison E.
Published: November 2024

Supplemental Figure 6
Figure S2 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Authors: Georgiev Peter , Han SeongJun , Huang Amy Y. , Nguyen Thao H. , Drijvers Jefte M. , Creasey Hannah , Pereira Joseph A. , Yao Cong-Hui , Park Joon Seok , Conway Thomas S. , Fung Megan E. , Liang Dan , Peluso Michael , Joshi Shakchhi , Rowe Jared H. , Miller Brian C. , Freeman Gordon J. , Sharpe Arlene H. , Haigis Marcia C. , Ringel Alison E.
Published: November 2024

Supplemental Figure 2
Supplementary Figure 12 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 12. The receiver operating characteristic curves of TAA burden and CTA burden for predicting ICB benefits in two HNSC ICB clinical trial datasets. Left panel shows a neoadjuvant trial of advanced-stage HNSC patients treated with the anti-PD-1 antibody nivolumab (Obradovic dataset). Right panel shows patients recruited for a neoadjuvant pembrolizumab trial (Uppaluri dataset). All patient subjects in the two trials are included in the analyses.
Supplementary Figure 11 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 11. TAA burden in responders and non-responders of nivolumab treatment in HNSC patients stratified based on Ecotyper CD8 S3 scores. Figure shows the patients from a neoadjuvant trial of advanced-stage HNSC patients treated with the anti-PD-1 antibody nivolumab (Obradovic dataset). P-values are based on one-tailed Welch’s T test.
Supplementary Figure 1 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 1. The pathological response rates of patients from different IC groups in the IMVigor210 trial.
Supplementary Data File S1 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Data File S1
Supplementary Table S1 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Primer sequences for real-time PCR
Figure S6 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S6. HER1-CAR-CAR-NK cells inhibit the migration and invasion of TNBC cells under H2O2-enriched and hypoxic conditions. (A) Scheme of the setup for the transwell migration assay. (B-C) Optical microscopic observation (B) and corresponding semiquantitative analysis (C) of the migration rate of parental and brain metastatic MDA-MB-231 cells after coincubation with different CAR-NK cells under different conditions, as indicated by the color code. (D) Scheme of the experimental schedule for the transwell invasion assay. (E-F) Optical microscopic examination (E) and corresponding semiquantitative analysis (F) of the invasion rate of parental and brain metastatic MDA-MB-231 cells after coincubation with different CAR-NK cells under different conditions, as indicated by the color code. (*p < 0.05).
Figure S3 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S3. The percentages of live parental MDA-MB-231 cells (A) and brain metastatic MDA-MB-231 cells (B) incubated with different concentrations of H2O2 for 24 h determined via propidium iodide staining.
Figure S17 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S17. The representative flow plots related to Figure 7G.
Figure S15 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S15. Figure 6B shows the individual tumor growth curves of PDX tumor-bearing mice subjected to different treatments.
Figure S14 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S14. Postoperative recurrence and brain metastasis rates.
Figure S10 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S10. The representative flow plots of Figure S10A-B are shown in Figure 4C-D.
Figure S1 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Authors: Pant Ayush , Jain Aanchal , Chen Yiyun , Patel Kisha , Saleh Laura , Tzeng Stephany , Nitta Ryan T. , Zhao Liang , Wu Caren Yu-Ju , Bederson Maria , Wang William Lee , Bergsneider Brandon Hwa-Lin , Choi John , Medikonda Ravi , Verma Rohit , Cho Kwang Bog , Kim Lily H. , Kim Jennifer E. , Yazigi Eli , Lee Si Yeon , Rajendran Sakthi , Rajappa Prajwal , Mackall Crystal L. , Li Gordon , Tyler Betty , Brem Henry , Pardoll Drew M. , Lim Michael , Jackson Christopher M.
Published: November 2024

Figure S1: CCR6 and CCL20 expression is increased in multiple tumors.
Data from Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
Authors: Xiang Xiaonan , Wang Kai , Zhang Hui , Mou Haibo , Shi Zhixiong , Tao Yaoye , Song Hongliang , Lian Zhengxing , Wang Shuai , Lu Di , Wei Xuyong , Xie Haiyang , Zheng Shusen , Wang Jianguo , Xu Xiao
Published: November 2024

Abstract
The efficacy of immune checkpoint inhibitors in the treatment of hepatocellular carcinoma (HCC) remains limited, highlighting the need for further investigation into the mechanisms underlying treatment resistance. Accumulating evidence indicates that tumor-associated macrophages (TAM) within the tumor microenvironment demonstrate a key role in immune evasion and treatment resistance. This study explored the role of TAMs in the HCC tumor microenvironment. Our findings reveal that TAMs expressing CX3C motif chemokine receptor 1 (CX3CR1) induced T-cell exhaustion through IL27 secretion in orthotopic models of HCC following treatment with anti-PD1. Moreover, we identified prostaglandin E2 (PGE2), released by immune-attacked tumor cells, as a key regulator of TAM transition to a CX3CR1+ phenotype. To augment the therapeutic response to anti-PD1 therapy, we propose targeting CX3CR1+ TAMs in addition to anti-PD1 therapy. Our study contributes to the understanding of the role of TAMs in cancer immunotherapy and highlights potential clinical implications for HCC treatment. The combination of targeting CX3CR1+ TAMs with anti-PD1 therapy holds promise for enhancing the efficacy of immunotherapeutic interventions in patients with HCC.
Data from Organ-Specific Immune Setpoints Underlie Divergent Immune Profiles across Metastatic Sites in Breast Cancer
Authors: Egelston Colt A. , Guo Weihua , Simons Diana L. , Ye Jian , Avalos Christian , Solomon Shawn T. , Nwangwu Mary , Nelson Michael S. , Tan Jiayi , Bacon Eliza R. , Ihle Kena , Schmolze Daniel , Tumyan Lusine , Waisman James R. , Lee Peter P.
Published: November 2024

Abstract
Immune composition within the tumor microenvironment (TME) plays a central role in the propensity of cancer cells to metastasize and respond to therapy. Previous studies have suggested that the metastatic TME is immune-suppressed. However, limited accessibility to multiple metastatic sites within patients has made assessing the immune TME difficult in the context of multiorgan metastases. We utilized a rapid postmortem tissue collection protocol to assess the immune composition of numerous sites of breast cancer metastasis and paired tumor-free tissues. Metastases had comparable immune cell densities and compositions to paired tumor-free tissues of the same organ type. In contrast, immune cell densities in both metastatic and tumor-free tissues differed significantly between organ types, with lung immune infiltration being consistently greater than that in the liver. These immune profiling results were consistent between flow cytometry and multiplex immunofluorescence–based spatial analysis. Furthermore, we found that granulocytes were the predominant tumor-infiltrating immune cells in lung and liver metastases, and these granulocytes comprised most PD–L1–expressing cells in many tissue sites. We also identified distinct potential mechanisms of immunosuppression in lung and liver metastases, with the lung having increased expression of PD-L1+ antigen-presenting cells and the liver having higher numbers of activated regulatory T cells and HLA-DRlow monocytes. Together, these results demonstrate that the immune contexture of metastases is dictated by organ type and that immunotherapy strategies may benefit from unique tailoring to the tissue-specific features of the immune TME.
Data from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Abstract
Oncolytic adenoviruses (oADV) are promising cancer treatment agents. However, in vivo hepatic sequestration and the host immunologic response against the agents limit the therapeutic potential of oADVs. In this study, we present a combined method with a rational design for improving oADV infection efficiency, immunogenicity, and treatment efficacy by self-biomineralization. We integrated the biomimetic nucleopeptide W6p into the capsid of oADV using reverse genetics, allowing calcium phosphate mineralization to be biologically induced on the surface of oADV under physiologic conditions, resulting in a mineral exterior. This self-biomineralized, modified oADV (oADV-W6-CaP) enhanced infection efficiency and therapeutic efficacy in coxsackievirus and adenovirus receptor (CAR)–negative cancer cells wherein protecting them against neutralization by preexisting neutralizing antibodies. In subcutaneous mouse tumor models, systemic injection of oADV-W6-CaP demonstrated improved antitumor effectiveness, which was associated with increased T-cell infiltration and CD8+ T-cell activation. In addition, the anticancer immune response elicited by oADV-W6-CaP was dependent on CD8+ T cells, which mediated long-term immunologic memory and systemic antitumor immunity against the same tumor. Finally, the addition of PD1 or CD47 inhibition boosted the anticancer effects of oADV-W6-CaP and increased the rate of complete tumor clearance in tumor-bearing animals. The self-biomineralized oADV shifted the suppressive tumor microenvironment from a “cold” to “hot” state and synergized with immune checkpoint blockade to exert outstanding tumoricidal effects, demonstrating promising potential for cancer immunotherapy.
Data from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Authors: Pant Ayush , Jain Aanchal , Chen Yiyun , Patel Kisha , Saleh Laura , Tzeng Stephany , Nitta Ryan T. , Zhao Liang , Wu Caren Yu-Ju , Bederson Maria , Wang William Lee , Bergsneider Brandon Hwa-Lin , Choi John , Medikonda Ravi , Verma Rohit , Cho Kwang Bog , Kim Lily H. , Kim Jennifer E. , Yazigi Eli , Lee Si Yeon , Rajendran Sakthi , Rajappa Prajwal , Mackall Crystal L. , Li Gordon , Tyler Betty , Brem Henry , Pardoll Drew M. , Lim Michael , Jackson Christopher M.
Published: November 2024

Abstract
Regulatory T cells (Treg) are important players in the tumor microenvironment. However, the mechanisms behind their immunosuppressive effects are poorly understood. We found that CCR6–CCL20 activity in tumor-infiltrating Tregs is associated with greater glycolytic activity and ablation of Ccr6 reduced glycolysis and lactic acid production while increasing compensatory glutamine metabolism. Immunosuppressive activity toward CD8+ T cells was abrogated in Ccr6−/− Tregs due to reduction in activation-induced glycolysis. Furthermore, Ccr6−/− mice exhibited improved survival across multiple tumor models compared to wild-type mice and Treg and CD8+ T-cell depletion abrogated the improvement. In addition, Ccr6 ablation further promoted the efficacy of anti-PD-1 therapy in a preclinical glioma model. Follow-up knockdown of Ccl20 with siRNA also demonstrated improvement in antitumor efficacy. Our results unveil CCR6 as a marker and regulator of Treg-induced immunosuppression and identify approaches to target the metabolic determinants of Treg immunosuppressive activity.
Table 5 from Increased Red Cell Superoxide Dismutase Activity Is Associated with Cancer Risk: A Hidaka Cohort Study
Authors: Tanaka Shin-ichiro , Fujioka Yoshio , Tsujino Takeshi , Ishida Tatsuro , Hirata Ken-ichi
Published: November 2024

Multivariable-adjusted analyses of sex-specific quartiles of R-SOD activities and cancer risk
Table 1 from Increased Red Cell Superoxide Dismutase Activity Is Associated with Cancer Risk: A Hidaka Cohort Study
Authors: Tanaka Shin-ichiro , Fujioka Yoshio , Tsujino Takeshi , Ishida Tatsuro , Hirata Ken-ichi
Published: November 2024

Baseline characteristics of the study cohort
Impact of the COVID-19 Pandemic on Cockroach Allergy: A 4-Year Retrospective Study
Authors: Evcen Recep , Çölkesen Fatih , Yıldız Eray , Sadi Aykan Filiz , Kılınç Mehmet , Arslan Şevket
Published: November 2024

Introduction: Sensitivity to indoor allergens increases the risks of asthma and the emergence of allergic diseases. Indoor allergens include house dust mite (HDM), pet dander, cockroach (CR), and molds. We investigated how CR sensitivity was affected during the pandemic period. Methods: This study included patients aged ≥18 years who visited the allergy unit of our clinic between March 2018 and March 2022 and who underwent skin prick tests (SPTs) for aeroallergens. Patients were divided into two groups: those of the prepandemic and pandemic periods, depending on the visit dates. Results: In all, 7,687 patients were recruited; 5,074 individuals with negative SPT results were excluded. Among the 2,613 atopic patients, CR sensitivity was detected in 278 (10.6%). The prevalence of CR sensitivity was significantly higher in the pandemic group than in the prepandemic group (12% vs. 8.6%; p < 0.05). The frequency of asthma was higher in patients with CR sensitivity than in others (33.1% vs. 26%, p = 0.011). In addition, individuals with CR sensitivity were older than others (p = 0.001). CR sensitivity was more common in males than in females (44.2% vs. 37.7%, p = 0.034). Moreover, dog and HDM sensitivities were more common in individuals with CR sensitivity than in others (p = 0.004, p < 0.001, respectively). Conclusion: This study reveals an increased sensitivity to CR during the pandemic and establishes an association between such sensitivity and the frequency of asthma. Variability in terms of CR sensitivity across different countries is emphasized. In addition, HDM and dog sensitivities were more common in individuals with CR sensitivity.
The Association between Migration and Prevalence of Allergic Diseases: A Systematic Review and Meta-Analysis
Authors: Wong Qi Yi Ambrose , Chew Fook Tim
Published: November 2024

Introduction: Allergic diseases remain of concern due to their increasing prevalence worldwide. Intrinsic and environmental risk factors have been implicated in the pathogenesis of allergic disease. Among the possible risk factors, migration has been associated with the manifestation of allergic diseases. We aimed to consolidate the existing evidence, review the hypotheses for the relationship between environmental factors and allergic disease, and provide a direction for future work. Methods: This systematic review and meta-analysis complied with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Web of Science database was searched in September 2023 to retrieve publications investigating the relationship between allergic rhinitis (AR), atopic dermatitis (AD), or asthma and the following factors: (i) migrant status (i.e., migrants vs. natives) or (ii) duration since migration among migrants. Risk of bias was assessed using the JBI critical appraisal tool. Details and findings from the included studies were also summarized and meta-analyses were conducted where appropriate. Results: Fifty studies encompassing an estimated 3,755,248 individuals were reviewed. Articles investigated asthma (n = 46), AR (n = 16), and AD (n = 14). A variety of migration-related factors were also studied: movement of individuals across regions (n = 40), duration since immigration (n = 12), age at immigration (n = 9), and acculturation (n = 2). Migration status was not significantly associated with AD (pooled odds ratio [pOR] = 0.68, 95% confidence interval (CI) = 0.31, 1.49). Although AR prevalence was lower among immigrants than natives (pOR = 0.58, 95% CI = 0.45, 0.74), immigrants who had resided at least 10 years in the destination country had a higher risk of AR than immigrants with a duration of residence of less than 10 years (pOR = 8.36, 95% CI = 4.15, 16.81). Being an immigrant was also associated with a decreased risk of asthma (pOR = 0.56, 95% CI = 0.44, 0.72). Among immigrants, residing in the host country for at least 10 years was associated with increased asthma manifestation (pOR = 1.85, 95% CI = 1.25, 2.73). Immigrants who migrated aged 5 and below did not exhibit a significantly higher likelihood of asthma than migrants who immigrated older than 5 years (pOR = 1.01, 95% CI = 0.68, 1.50). Conclusion: This review was limited by the primarily cross-sectional nature of the included studies. Objective diagnoses of allergic disease, such as using the spirometry of bronchodilator reversibility test for asthma rather than questionnaire responses, could add to the reliability of the outcomes. Furthermore, immigrant groups were mostly nonspecific, with little distinction between their country of origin. Overall, migration appears to be a protective factor for allergic diseases, but the protection subsides over time and the prevalence of allergic diseases among the immigrant group approaches that of the host population.
FIBRINOLYSIS WAS REPLACED BEFORE IT WAS UNDERSTOOD
Authors: Gurewich Victor , Segarnick David
Published: November 2024

Introduction

Fibrinolysis is often wrongly believed to be due to tissue plasminogen activator (tPA) alone. Instead, both endogenous plasminogen activators are required, but only a mini bolus of tPA is needed to initiate fibrinolysis. This is due to tPA’s unique high fibrin affinity binding site located on the fibrin D-domain. Both activators are present in all normal plasma, consistent with both being involved in biological fibrinolysis, which is also the model for optimal therapeutic fibrinolysis.

Methods

This uses a sequential combination of a 5 mg mini bolus of tPA followed by an infusion of proUK (40 mg/hr) for 90 minutes. This treatment is both highly effective and free of side effects.

Results

By contrast, due to a misunderstanding of fibrinolysis, tPA is often administered alone. This requires doses of 90-100 mg of tPA over 60 minutes, which is neither very effective nor safe, due to a risk of bleeding complications from the lysis of hemostatic fibrin by tPA’s fibrin affinity. Due to this problem, fibrinolysis was replaced by interventional procedures, like percutaneous coronary intervention (PCI), which is much slower, limited to clots larger than the catheter, but is generously reimbursed by third party payers.
Management strategies and corticophobia among healthcare professionals involved in the care for atopic dermatitis: a Dutch survey
Authors: Ragamin Aviël , van Halewijn Karlijn F. , Schappin Renske , Witkam Willemijn C.A.M. , Arends Nicolette J.T. , Hoogeterp Jaap , Bohnen Arthur M. , Elshout Gijs , Schuttelaar Marie L.A , Pasmans Suzanne G.M.A.
Published: November 2024

Background:
Many healthcare professionals (HCPs) deliver care for patients with atopic dermatitis (AD). Although pivotal, management strategies and the relation with corticophobia among HCPs have not been investigated. This study aimed to investigate management strategies for AD and its relation with corticophobia among HCPs.
Methods:
Dutch general practitioners (GPs), youth healthcare physicians (YHPs), pediatricians, dermatologists, pharmacists, and pharmacy assistants participated in a survey on management strategies and corticophobia. The Topical Corticosteroid Phobia questionnaire for professionals (TOPICOP-P) was used to measure attitudes toward topical corticosteroids (TCS). Higher scores reflect a more negative attitude.
Results:
A total of 407 HCPs (124 GPs, 33 YHPs, 51 pediatricians, 56 dermatologists, 58 pharmacists, and 85 pharmacy assistants) participated. Compared to dermatologists other HCPs were more reluctant with TCS as illustrated by the portion (50%) of GPs that reported to prescribe TCS of only mild potency for infants with severe AD, compared to dermatologists (9%). Dermatologists had lowest TOPICOP-P scores (median: 19, IQR:12-28). GPs and pharmacy assistants had highest scores (GPs median: 36, IQR:31-44, pharmacy assistants: median: 36, IQR:31-42). More corticophobia was significantly associated with prescription of a lower TC potency class (B -0.04, 95%CI: -0.07-0.01, P=0.01), and a trend was found between more corticophobia and longer perceived durability of one TCS tube.
Conclusions:
This study shows the differences in management of AD and reluctance towards TCS in HCPs. Furthermore, corticophobia among HCPs and its effect on management of AD was confirmed. To reduce corticophobia and improve care for AD, more education is needed.
Dossiê Terror e intimidade: perspectivas etnográficas e desafios conceituais
Authors: Vianna Adriana , Facundo Navia Angela , Efrem Filho Roberto
Published: November 2024

The Special Issue proposed here gathers five articles that, stemming from ethnographic research, propose a reflection on the radical relationship between terrorist practices and experiences of intimacy. The Special Issue focuses on the ways in which these two dimensions are linked, suggesting that terrorist practices involve technologies that directly affect experiences considered intimate, concerning bodies, homes, routines, and affections. We argue, with the present proposal, that this is also why the effects of such practices reverberate far beyond the time and place in which they occur. Starting from ethnographic contexts involving routines of state violence in the favelas of Rio de Janeiro; an episode of sexual violence in an agrarian conflict in Paraíba; experiences of forced displacement and exile related to the Colombian conflict; and the armed conflict in Brazil from its urban peripheries; we also want to investigate the political effects of the presence of terror in the midst of everyday life and intimate networks of relationships.
Sobre santos, doces e crianças: devoções a Cosme e Damião no Rio de Janeiro
Authors: Oliveira Sueli do Carmo
Published: November 2024

A review of the book ‘Doces Santos: devções a Cosme e Damião’, organised by Renata Menezes, Lucas Bártolo and Morena Freitas and published by the National Museum/UFRJ in 2020.
Cartografiar los cuidados: salud, género y territorialidades en la periferia de Posadas (Misiones, Argentina)
Authors: Lorenzetti Mariana Isabel , Avalos Miguel Alejandro , Almada Jorge Sebastián
Published: November 2024

En este trabajo analizamos los significados y las prácticas de cuidados para la reproducción de la vida en contextos de pauperización agudizados en la postpandemia. Reflexionamos sobre el potencial de la cartografía social en el enfoque etnográfico, como modalidad de trabajo colaborativo para la reconstrucción de las redes de cuidado en salud. Retomamos la experiencia de un mapeo comunitario realizado con la Coordinadora de Trabajadores Desocupados Aníbal Verón Nacional (Posadas-Misiones). La cartografía social constituyó una herramienta para la interpretación de las dinámicas sociales entre las familias, los espacios comunitarios y las agencias estatales, recuperando particularmente la mirada de las mujeres. Desde el ensamble del dibujo-narración reconstruimos la gramática de las interacciones y reciprocidades que configuran la territorialidad de los cuidados donde se ponen en juego distintos alcances de las nociones de salud.
O Vigia/Watchman: mulheres espectrais
Authors: Oliveira Flávio Célio Rodrigues , Araújo Aryanne de Oliveira
Published: November 2024

Busca dar continuidade às análises de artigos anteriores que relacionam as obras O Vigia/Watchman do artista Flávio CRO, a história em quadrinhos Watchmen, de Alan Moore e Dave Gibbons, e a obra literária 1984 de George Orwell, a partir das percepções possíveis sobre o feminino nessas obras. A análise se dará a partir dos estudos feministas sobre gênero e a espectatorialidade com Teresa de Lauretis e Laura Mulvey, observando as continuidades e deslocamentos da imagem da mulher na tradição dos produtos da cultura pop. Adicionalmente, são levantadas as questões dos espectros de Jacques Derrida como rastros da presença/ausência do feminino nas tramas analisadas. Em sua maioria, as personagens mulheres das produções citadas são colocadas em posições secundárias que servem ao propósito de sustentar a construção do caráter dos heróis e anti-heróis na história. Observa-se nas associações dos nomes das personagens “Espectral” (mãe e filha) uma possível denúncia e apontamento do lugar fantasmagórico desses corpos femininos na tradição dos quadrinhos, assim como a existência da personagem Júlia é mediada pela memória e voz espectral de Winston em 1984.
Racial and Socioeconomic Health Disparities in Peripheral Artery Disease
Authors: Thomas Victoria E. , Beckman Joshua A.
Published: November 2024

Peripheral artery disease (PAD) is a progressive atherosclerotic disease that causes lower extremity arterial stenosis or occlusion. Patients with PAD are at increased risk of myocardial infarction, stroke, limitations in ambulation, and amputation. Despite the advances in medicine and technology, the outcomes from PAD, including critical limb‐threatening ischemia, acute limb ischemia amputation, and mortality, remain increased among specific racial and ethnic groups that have been historically marginalized in America, including Black, Hispanic, and American Indian individuals in the United States when compared with White persons. The purpose of this review is to summarize PAD literature that incorporates racial and ethnic disparities in PAD. There are a rising number of studies focused on the interface of racial and ethnic disparities and PAD. The majority of these studies are specifically focused on Black race, whereas there are limited studies focused on other minoritized racial and ethnic groups in the United States. The application of race and ethnicity has also been shown to play a synergistic role with socioeconomic status on PAD outcomes. Effective strategies focused on implementing policies that support quality measures and focus on social determinants of health have been shown to promote health equity and reduce disparities. Current evidence suggests that biological differences are less likely to be the leading cause of disparities in PAD between racial and ethnic groups compared with White Americans and supports a renewed focus on social determinants of health to achieve health equity.
Clinical Significance of Optical Coherence Tomography–Guided Percutaneous Coronary Intervention for In‐Stent Restenosis Within Drug‐Eluting Stents: Impact on Patient Outcomes
Authors: Han Yan , Yuan Xiaohang , Wang Wei , Wang Ningyuan , Zhang Yingqian , Jing Jing , Chen Yundai , Gao Lei
Published: November 2024

Background

The evidence for optical coherence tomography (OCT)–guided percutaneous coronary intervention (PCI) in improving the prognosis of individuals with in‐stent restenosis (ISR) is lacking.

Methods and Results

This retrospective study enrolled 588 consecutive individuals with drug‐eluting stent ISR undergoing PCI from March 2010 to March 2022. Two hundred seven (35.2%) underwent OCT guidance, and 381 (64.8%) underwent angiography guidance. Clinical outcomes were analyzed using survival curves. The primary clinical endpoint was 2‐year major adverse cardiovascular events (MACEs), a composite of all‐cause death, myocardial infarction, and target‐vessel revascularization. Compared with angiography guidance, OCT guidance demonstrated a higher frequency of drug‐coated balloon use and adjunctive therapeutic modalities, including predilation, postdilation, nonslip element balloons, and noncompliant balloons (
P
<0.05). Following PCI, the OCT‐guided group achieved a significantly larger minimum lumen diameter (2.36 versus 2.15 mm,
P
<0.001) and a lower percentage diameter stenosis (17% versus 20%,
P
<0.001) than the angiography‐guided group. Survival analysis revealed significantly lower 2‐year MACEs in the OCT‐guided group compared with the angiography‐guided group (7% versus 15%,
P
=0.007), validated in the propensity matching analysis (7% versus 15%,
P
=0.001). Multiple sensitivity analyses showed that OCT‐guided PCI treatment was an independent protective factor for 2‐year MACEs in individuals with drug‐eluting stent ISR.

Conclusions

Compared with angiography guidance, OCT guidance is associated with a lower 2‐year MACE risk among individuals with drug‐eluting stent ISR. Therefore, OCT should be actively considered for guiding PCI treatment in individuals with drug‐eluting stent ISR.

Registration

Url:
clinicaltrials.gov
. Identifier: NCT03809754.
Effect of Intravenous Tirofiban Versus Placebo on First‐Pass Successful Reperfusion in Endovascular Stroke Thrombectomy: Insights From the RESCUE BT Randomized Clinical Trial
Authors: Yuan Junjie , Ge Hanming , Tao Zhaojun , An Huijie , Han Qin , Saver Jeffrey L. , Nguyen Thanh N. , Zhou Simin , Mao An , Wu Yuelu , Nogueira Raul Gomes , Sun Yaxuan , Jiang Shunfu , Wei Liping , Fu Xinmin , Bai Yongjie , Yang Shunyu , Hu Wei , Zhang Guling , Pan Chengde , Zhang Shuai , Qiao Lin , Chen Qiong , Sang Hongfei , Qiu Zhongming , Wu Fengfu , Chang Mingze , Ruan Zhongfan
Published: November 2024

Background

First‐pass successful reperfusion (FPSR), defined as a successful/complete reperfusion achieved after a single thrombectomy pass, is predictive of favorable outcome in patients with acute ischemic stroke with large‐vessel occlusion. It is unknown whether intravenous tirofiban is effective in increasing the rate of FPSR in acute anterior large‐vessel occlusion stroke.

Methods and Results

Patients who had acute large‐vessel occlusion stroke presenting within 24 hours and underwent endovascular thrombectomy were analyzed from the RESCUE BT (Intravenous Tirofiban for Patients With Large Vessel Occlusion Stroke) clinical trial, of which the main analysis was neutral. The RESCUE BT trial randomized patients to receive either intravenous tirofiban or placebo before endovascular thrombectomy. The primary end point was FPSR, defined as successful reperfusion (extended thrombolysis in cerebral infarction scale 2b50, 2c, or 3) at first thrombectomy attempt. A modified Poisson regression analysis assessed the association between intravenous tirofiban treatment and FPSR. Of 948 enrolled patients, 463 patients were randomized to the tirofiban group and 485 to the placebo group. The mean age was 67 years, and 41.0% of the patients were women. FPSR was achieved more often in the tirofiban group (30.5% versus 23.5%; adjusted risk ratio, 1.24 [95% CI, 1.01–1.51];
P
=0.04). FPSR was associated with a favorable shift to lower modified Rankin Scale disability levels at 90 days (common odds ratio, 1.42 [95% CI, 1.08–1.86];
P
=0.01).

Conclusions

In this post hoc analysis of the RESCUE BT trial, treatment with intravenous tirofiban before endovascular thrombectomy was associated with increased FPSR in patients with acute ischemic stroke due to large‐vessel occlusion in the anterior circulation. FPSR was associated with reduced 90‐day levels of disability.

Registration

URL:
http://chictr.org
; Unique Identifier: ChiCTR‐INR‐17014167.
Quercus purhepecha (Fagaceae), a new species of shrub oak endemic to the state of Michoacán, Mexico
Authors: LUNA-BONILLA OSCAR ANGEL DE , GONZÁLEZ-RODRÍGUEZ ANTONIO , RODRÍGUEZ-CORREA HERNANDO , PIÑA-TORRES JAVIER , COOMBES ALLEN J. , VALENCIA-A. SUSANA
Published: November 2024

Within the genus Quercus there are species with a shrubby habit that have been little studied worldwide. In Mexico, several shrub species within section Quercus are taxonomically highly problematic. These include eight named taxa that share traits such as abaxially tomentose leaves and growth of stems from one or multiple rhizomes, and there is evidence of additional undescribed species. Here, Quercus purhepecha is described and illustrated as a new tomentose shrubby white oak species, with a very restricted distribution within the Cuitzeo basin in the Trans-Mexican Volcanic Belt (TMVB), Michoacán state, Mexico. This new species is morphologically compared with Q. frutex, Q. microphylla and Q. repanda, which are similar taxa also distributed in the TMVB. In addition, a potential distribution model of Q. purhepecha for the Cuitzeo basin is presented.
Clematis jialasaensis var. macrantha and C. napoensis (Ranunculaceae), another two new synonyms of C. armandi from China
Authors: HUANG QIAO-LAN , FEI WEN-QUN , YUAN QIONG , YANG QIN-ER
Published: November 2024

Based on consultation of literature, survey of specimens (including type material), and observations of living plants in the wild, we confirm that Clematis jialasaensis var. macrantha and C. napoensis (Ranunculaceae), described respectively from northeastern Yunnan and southwestern Guangxi, China, actually belong to C. armandi, a species widely distributed in the country. We therefore place both C. jialasaensis var. macrantha and C. napoensis in synonymy with C. armandi. We also determine that two collections of Clematis, J.M. Delavay 4 and J.M. Delavay 5146, from Tchen-fong Chan in northeastern Yunnan, China, the type locality of C. jialasaensis var. macrantha, also belong to C. armandi. These two collections have been previously referred to C. meyeniana or C. finetiana.
Biography and contributions of Joaquim do Espírito Santo (1901-1984) to the botany of Guinea-Bissau and São Tomé and Príncipe
Authors: LIMA RICARDO FAUSTINO DE , SILVA VASCO , DUARTE MARIA CRISTINA , CATARINO LUÍS
Published: November 2024

A biography of Joaquim Viegas da Graça do Espírito Santo (1901–1984) is provided by integrating information from botanical collections and from his record as a civil servant. Born in São Tomé Island (São Tomé and Príncipe), he finished his studies in Portugal in 1924, spent most of his career as an agricultural technical engineer in Guinea-Bissau (1927–1956), and after retiring continued collecting, mostly in São Tomé. He collected at least 5 412 herbarium specimens, including 23 types of plant names. He remains the most prolific plant collector in Guinea-Bissau and is a somewhat neglected collector in São Tomé and Príncipe. He also produced 22 publications. Finally, these contributions are contextualised, taking into consideration that he was one of the few non-white plant collectors from the Portuguese colonial period, while being a member of a family that was pivotal in the inception of independence movements in Lusophone Africa.
A revision and addition to Zopheridae (Coleoptera: Tenebrionoidea) in Baltic amber: possible connections between modern Holarctic distributions and Eocene ‘amber forests’
Authors: ALEKSEEV VITALII , MCKELLAR RYAN C. , BUKEJS ANDRIS
Published: November 2024

One new extinct genus and six new extinct species of Zopheridae are described and illustrated from Eocene Baltic amber: Usechus andrushchenkoi Alekseev et Bukejs sp. nov., Coxelus carstengroehni Alekseev et Bukejs sp. nov., Paha vanivanitatum Alekseev et Bukejs sp. nov., Lasconotus tenebrisilvarum Alekseev et Bukejs sp. nov., Helioctamenus groehni Alekseev et Bukejs sp. nov., and Thanatoplagia tamutisi Alekseev et Bukejs gen. et sp. nov. These described taxa include the first fossil representatives of five extant genera and two extant tribes of the family Zopheridae. The assumed paleoecology of these taxa within the amber-producing forest paleohabitat, as well as zoogeography of new fossils are discussed. In addition, new fossil records of Xylolaemus legalovi Alekseev et Bukejs, 2016, X. richardklebsi Alekseev et Bukejs, 2016, Endophloeus gorskii Alekseev et Bukejs, 2016, Yantaroxenos colydioides Nabozhenko, Kirejtshuk et Merkl, 2016, and Zopheromimus auriborussiensis Alekseev et Nabozhenko, 2023 from Baltic amber are presented. A catalogue of Zopheridae described from Baltic amber (currently 19 species within 16 genera) is compiled herein, and an identification key for all taxa is provided. The zoogeographical affinities of the Baltic amber zopherid assemblage are assessed. The present-day disjunct distributions of the zopherid genera that have survived since the Eocene and are currently present in the Holarctic region probably resulted from a uniform fauna in the warm temperate regions of the Northern Hemisphere in the first half of the Paleogene. This uniform fauna was followed by independent reduction of distributions within four regions (West Palearctic, East Palearctic, West Nearctic, and East Nearctic). The ‘circum-Arctic quadrants’ schema is proposed for visualisation of this hypothesis. Additionally, a zonal middle to late Eocene ‘amberiferous ring’ is hypothesized as a probable migration pathway for several zopherids in this part of the Eocene. This ‘ring’ is a belt of amber-producing forests in the Northern Hemisphere, with the potential to preserve a wider distribution of taxa that relied on mixed conifer-fagacean forests similar to the Baltic amber forest flora and its faunal assemblage.
Psammobiont halacarid mites (Acari: Halacaridae) from Türkiye: description of two new species of the genus Atelopsalis Trouessart, 1896 and Scaptognathus Trouessart, 1889 and two new records
Authors: DURUCAN FURKAN
Published: November 2024

In this paper, two new species from the genera Atelopsalis Trouessart, 1896 and Scaptognathus Trouessart, 1889 are described from the eastern Mediterranean Sea, off the coast of Antalya, Türkiye. Atelopsalis mediterranea sp. nov. is described based on female, male, and deutonymph specimens collected from soft sand sediment in Kaş, Antalya. Scaptognathus antalyaensis sp. nov. is described based on female and male specimens from soft sediment in Kundu, Antalya. In addition to these new species, two arenicolous halacarid mites, Acarochelopodia delamarei Angelier, 1954 and Anomalohalacarus anomalus (Trouessart, 1894), are reported from the Turkish coasts for the first time. Both psammic halacarid mites were found in medium coarse sand sediment habitats at Örnekköy Beach.
A Framework for Understanding Credibility: What Makes Credible Messengers “Credible” in a New York City–Based Sample of Gun Violence Intervention Programs?
Authors: Szkola Jason , Blount-Hill Kwan-Lamar
Published: November 2024

The use of credible messengers to deliver violence reduction programs has spread rapidly since it was first used in a criminal justice context by Cure Violence in 1999. However, there is no clear conceptualization of what a credible messenger is, aside from vague definitions contained in the evaluation literature. We provide a “broad strokes” framework for developing a general theory of credibility that might extend from criminal justice across disciplines. The framework also provides the basis for developing a middle theory on credibility within the area of violence intervention. We demonstrate how this might be done, using the theoretical framework to explore a set of 22 interviews with credible messenger staff.