bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors for the development of macular edema in children with uveitis
Authors: Friling Ronit , Berliner Ori , Eiger-Moscovich Maya , Chen Yi-Hsing , Tomkins-Netzer Oren , Kramer Michal
Published: June 2023

Aim

To determine the risk factors for macular edema (ME) in children with uveitis.

Methods

A retrospective study was conducted of 150 pediatric patients (264 eyes) with uveitis attending 2 tertiary medical centers. Data were collected from the medical files on demographics, type of uveitis, etiology, clinical findings, treatment, and time to development of ME. Risk factors for the development of ME were identified.

Results

ME developed in 63 eyes (23.9%) over a mean period of 15.3 ± 2.95 months from diagnosis of uveitis, at a rate of 0.08 eyes per eye-year. On univariate analysis, risk factors for the development of ME were the non-anterior location of the inflammation (p=0.002), band keratopathy (p <0.0001), posterior synechiae (p=0.003), cataract (p=0.002), and vision impairment at presentation (p <0.0001). On multivariate analysis, non-anterior uveitis, which includes intermediate, pan, and posterior-uveitis, and vision impairment retained significance as independent risk factors of ME.

Conclusion

Within the pediatric population with uveitis, non-anterior location is associated with the highest risk of ME, followed by the presence of complications, such as band keratopathy and posterior synechiae. These findings indicate a need for close follow-up in children with uveitis for early detection of ME.
Use of perennial plants in the fight against gastrointestinal nematodes of sheep
Authors: Bosco Antonio , Prigioniero Antonello , Falzarano Alessandra , Maurelli Maria Paola , Rinaldi Laura , Cringoli Giuseppe , Quaranta Giovanni , Claps Salvatore , Sciarrillo Rosaria , Guarino Carmine , Scarano Pierpaolo
Published: June 2023

Background

Gastrointestinal nematodes (GINs) are a serious problem in ruminant pastures worldwide. They generate production losses, from the point of view of both the food chain and animal mortality. This study provides preliminary results concerning the use of pasture plants in the Campania region (of southern Italy) to control GINs in sheep.

Methods

Sixteen species of wild and cultivated perennial plants present in seminatural pastures were sampled. All species were extracted with the conventional maceration technique, using three different solvents (i.e., H2O, EtOH, and an EtOH:H2O (8:2) mixture) in order to extract different bioactive compounds. The total phenolic content (TPC; assessed via the Folin–Ciocȃlteu assay) of all extract samples was preliminarily characterized. Each sample was aliquoted across six different concentrations and an in vitro egg hatching test (EHT) was conducted to evaluate the ovicidal effect on sheep GINs.

Results

The results indicated that Cichorium intybus L. and Foeniculum vulgare Mill. extracts greatly inhibited egg hatching within 48 hours of exposure, showing efficacy (≥ 62.6%) at the three higher concentrations when compared with the other plants.

Conclusion

The use of extracts of wild and cultivated perennial plant species in pastures can be a valid alternative to the use of synthetic anthelmintic drugs, which can generate problems, such as anthelmintic resistance, in the long term. Looking forward, further in vitro studies that evaluate the in vitro effect of these extracts on ruminant cell cultures, and field application through in vivo studies, would likely confirm the results obtained from preliminary in vitro EHTs. All these studies should be aimed at evaluating the therapeutic potential and future applicability of specific plant cultures in pastures to achieve sustainable pest control.
An evaluation of the association between lockdown during the SARS-CoV-2 pandemic and prematurity at the Nice University Hospital
Authors: Lorenzi Marine , Mayerus Mathilde , Eleni Dit Trolli Sergio , Hue-Bigé Amandine , Legueult Kévin , Guellec-Renne Isabelle , François-Garret Bérengère
Published: June 2023

Aim

To study the association between lockdown in France due to the SARS-CoV-2 pandemic and premature births at the Nice University Hospital.

Methods

Data concerning neonates born at the level III maternity of the Nice University Hospital and immediately hospitalised in the neonatal reanimation unit or the neonatology department of the hospital with their mothers between the 1st of January 2017 and the 31st of December 2020, included.

Results

We did not find a significant decrease in the global number of premature births <37 weeks of gestation, in low weight at birth or a significant increase in stillbirths during lockdown compared to a period with no lockdown. The profiles of the mothers and their newborns were compared when birth occurred during lockdown vs. no lockdown.

Conclusion

We did not find any evidence of an association between lockdown and prematurity at the Nice University Hospital. This result is in agreement with meta-analyses published in the medical literature. The possible decrease in factors of risk of prematurity during lockdown is controversial.
Selected cutaneous adverse events in patients treated with ICI monotherapy and combination therapy: a retrospective pharmacovigilance study and meta-analysis
Authors: Lu Wenchao , Zhang Huiyun , Guo Qixiang , Gou Zhuoyue , Yao Jiannan
Published: June 2023

Introduction: Cutaneous adverse events are commonly reported immune-related adverse events (irAEs), some of which are serious or even life-threatening, and it is essential to study these specific cutaneous AEs to understand their characteristics and risk.

Methods: We performed a meta-analysis of published clinical trials for immune checkpoint inhibitors (ICIs) to evaluate the incidence of cutaneous adverse events, using data from PubMed, Embase, and the Cochrane Library databases.

Results: A total of 232 trials with 45,472 patients were involved. Results showed that anti-PD-1 and targeted therapy combinations were associated with higher risk for most of the selected cutaneous adverse events. In addition, a retrospective pharmacovigilance study was conducted using the Food and Drug Administration (FDA) Adverse Events System database. Reporting odds ratio (ROR) and Bayesian information components (IC) were used to perform the disproportionality analysis. Cases were extracted from January 2011 to September 2020. We identified 381 (20.24%) maculopapular rash, 213 (11.32%) vitiligo, 215 (11.42%) Stevens‐Johnson syndrome (SJS), and 165 (8.77%) toxic epidermal necrolysis (TEN) cases. For vitiligo, anti-PD-1/L1 combined with anti-CTLA-4 therapy showed the strongest signal (ROR: 55.89; 95% CI: 42.34–73.78; IC025: 4.73). Palmar-plantar erythrodysesthesia (PPE) was reported with the most significant association with combined anti-PD-1/L1 and VEGF (R)-TKIs (ROR: 18.67; 95% CI: 14.77–23.60; IC025: 3.67). For SJS/TEN, antiPD-1 inhibitors showed the strongest signal (ROR: 3.07; 95% CI: 2.68–3.52; IC025: 1.39). The median onset time of vitiligo and SJS/TEN was 83 and 24 days, respectively.

Conclusion: Overall, in selected cutaneous AEs, each of them showed specific characteristics. It is necessary to realize their differences and take appropriate interventions in patients with different regimens.
Achieving abiotic stress tolerance in plants through antioxidative defense mechanisms
Authors: Mishra Neelam , Jiang Chenkai , Chen Lin , Paul Abhirup , Chatterjee Archita , Shen Guoxin
Published: June 2023

Climate change has increased the overall impact of abiotic stress conditions such as drought, salinity, and extreme temperatures on plants. Abiotic stress adversely affects the growth, development, crop yield, and productivity of plants. When plants are subjected to various environmental stress conditions, the balance between the production of reactive oxygen species and its detoxification through antioxidant mechanisms is disturbed. The extent of disturbance depends on the severity, intensity, and duration of abiotic stress. The equilibrium between the production and elimination of reactive oxygen species is maintained due to both enzymatic and non-enzymatic antioxidative defense mechanisms. Non-enzymatic antioxidants include both lipid-soluble (α-tocopherol and β-carotene) and water-soluble (glutathione, ascorbate, etc.) antioxidants. Ascorbate peroxidase (APX), superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR) are major enzymatic antioxidants that are essential for ROS homeostasis. In this review, we intend to discuss various antioxidative defense approaches used to improve abiotic stress tolerance in plants and the mechanism of action of the genes or enzymes involved.
Two distinct light-induced reactions are needed to promote germination in spores of Ceratopteris richardii
Authors: Cannon Ashley E. , Sabharwal Tanya , Salmi Mari L. , Chittari Ganesh Kumar , Annamalai Valli , Leggett Lindsey , Morris Hope , Slife Cameron , Clark Greg , Roux Stanley J.
Published: June 2023

Germination of Ceratopteris richardii spores is initiated by light and terminates 3-4 days later with the emergence of a rhizoid. Early studies documented that the photoreceptor for initiating this response is phytochrome. However, completion of germination requires additional light input. If no further light stimulus is given after phytochrome photoactivation, the spores do not germinate. Here we show that a crucial second light reaction is required, and its function is to activate and sustain photosynthesis. Even in the presence of light, blocking photosynthesis with DCMU after phytochrome photoactivation blocks germination. In addition, RT-PCR showed that transcripts for different phytochromes are expressed in spores in darkness, and the photoactivation of these phytochromes results in the increased transcription of messages encoding chlorophyll a/b binding proteins. The lack of chlorophyll-binding protein transcripts in unirradiated spores and their slow accumulation makes it unlikely that photosynthesis is required for the initial light reaction. This conclusion is supported by the observation that the transient presence of DCMU, only during the initial light reaction, had no effect on germination. Additionally, the [ATP] in Ceratopteris richardii spores increased coincidentally with the length of light treatment during germination. Overall, these results support the conclusion that two distinct light reactions are required for the germination of Ceratopteris richardii spores.
On the contrasting morphological response to far-red at high and low photon fluxes
Authors: Kusuma Paul , Bugbee Bruce
Published: June 2023

Plants compete for sunlight and have evolved to perceive shade through both relative increases in the flux of far-red photons (FR; 700 to 750 nm) and decreases in the flux of all photons (intensity). These two signals interact to control stem elongation and leaf expansion. Although the interacting effects on stem elongation are well quantified, responses for leaf expansion are poorly characterized. Here we report a significant interaction between far-red fraction and total photon flux. Extended photosynthetic photon flux density (ePPFD; 400 to 750 nm) was maintained at three levels (50/100, 200 and 500 µmol m-2 s-1), each with a range of 2 to 33% FR. Increasing FR increased leaf expansion in three cultivars of lettuce at the highest ePPFD but decreased expansion at the lowest ePPFD. This interaction was attributed to differences in biomass partitioning between leaves and stems. Increased FR favored stem elongation and biomass partitioning to stems at low ePPFD and favored leaf expansion at high ePPFD. In cucumber, leaf expansion was increased with increasing percent FR under all ePPFD levels showing minimal interaction. The interactions (and lack thereof) have important implications for horticulture and warrant further study for plant ecology.
Simulated microgravity affects directional growth of pollen tubes in candidate space crops
Authors: Iovane Maurizio , Izzo Luigi Gennaro , Romano Leone Ermes , Aronne Giovanna
Published: June 2023

Background

Long-term space missions will necessarily require producing viable seeds to be used for plant cultivation over time under altered gravity conditions. Pollen is known to play a key role in determining seed and fruit production over seed-to-seed cycles, but very few studies have evaluated pollen functionality under altered gravity.

Methods

We performed ground-based experiments to test how simulated microgravity can affect the directional growth of pollen tubes as a potential bottleneck in seed and fruit sets. The effect of clinorotation was assessed in the pollen of Solanum lycopersicum L. cv. ‘Micro-Tom’ and Brassica rapa L. var. silvestris, both eligible for cultivation in space. Pollen tube length and tortuosity were compared under 1g and simulated microgravity with a uniaxial clinostat.

Results

The main results highlighted that simulated microgravity significantly increased pollen tube length and tortuosity compared to 1g conditions. Further, clinorotation prompted a differential effect on pollen germination between S. lycopersicum and B. rapa. A more in-depth analysis evaluating the effect of gravity on the directional growth of pollen tubes excluded gravitropic responses as responsible for the tube tip position reached after germination.

Discussion

This research provides new insights into how altered gravity can interfere with plant reproduction and, in particular, microgametophyte functionality. Our findings represent a basis for further studies aimed at understanding the effect of real microgravity on plant reproduction and developing countermeasures to ensure seed-to-seed cultivation in long-term space missions and achieve self-sufficiency in food supplies from Earth.
Quality of life and emotional distress in sarcoma patients diagnosed during COVID-19 pandemic: a supplementary analysis from the SarCorD study
Authors: Onesti Concetta Elisa , Vari Sabrina , Minghelli Denise , Nardozza Francesca , Rossi Barbara , Sperati Francesca , Checcucci Elisa , Faltyn Wioletta , Cercato Maria Cecilia , Cosimati Antonella , Salvatori Francesca , Biagini Roberto , Ciliberto Gennaro , Ferraresi Virginia , Maggi Gabriella
Published: June 2023

Background

The COVID-19 outbreak had a negative psychological impact on cancer patients. In this study, we analyzed emotional distress and quality of life in patients diagnosed with sarcoma during the first year of the pandemic compared to the previous year.

Methods

We retrospectively enrolled patients with soft tissue, bone sarcoma, and aggressive benign musculoskeletal diseases diagnosed during the pandemic (COVID group) or the year before (control group) at the IRCCS Regina Elena National Cancer Institute in Rome. Patients who had undergone a psychological assessment with the EORTC QLQ-C30 and the Distress Thermometer at diagnosis were included in the final analysis. We analyzed whether there is a difference in the various domains of quality of life between the two groups and whether there are changes over time in each group.

Results

We enrolled 114 patients (72 control group; 42 COVID group), affected by soft tissue (64%), bone sarcoma (29%), and aggressive benign musculoskeletal diseases (7%). We did not observe significant differences in the health-related quality of life domains in the control and COVID groups, except for the financial domain (p = 0.039), with 9.7% vs. 23.8% of patients with a score > 0 in the control and COVID groups, respectively. We observed emotional distress at diagnosis in 48.6% of patients in the control group vs. 69.0% in the COVID group (p = 0.034). In the control group, we observed an improvement in physical function (p = 0.043) and in QoL (p = 0.022), while in the COVID group, we observed a deterioration in role function (p = 0.044) during follow-up. In the COVID group, 22.2% of patients were concerned about COVID-19, 61.1% by tumor, 91.1% stated that the pandemic worsened their subjective perception of cancer, and 19.4% perceived that their quality of care had worsened.

Conclusion

We observed a higher level of distress among patients diagnosed during the pandemic compared to the year before, probably due to the increased concern for both infection and cancer, the worsened perception of health status, and the perception of a poorer quality of health care.
Stressors related to the COVID-19 pandemic and their association with distress, depressive, and anxiety symptoms in cancer out-patients
Authors: Frank Tamara , Pichler Theresia , Maier Sabrina , Batenhorst Ineke , Abawi Tanja , Harbeck Nadia , Algül Hana , Heinemann Volker , Hermelink Kerstin , Mumm Friederike , Dinkel Andreas
Published: June 2023

Patients with cancer might be particularly prone to stress caused by the COVID-19 pandemic. The aim of this study was to investigate the impact of pandemic-related stressors on oncological patients’ psychological well-being. During the second wave of the COVID-19 pandemic in Germany 122 cancer out-patients of the Comprehensive Cancer Center Munich reported on COVID-19-related stressors (information satisfaction, threat perception, and fear of disease deterioration) and answered standardized questionnaires for psychosocial distress (DT) as well as depression and anxiety symptoms (PHQ-2, GAD-2). Multiple linear regression analyses were used to identify associations of the COVID-19-related stressors with psychological symptoms, controlling for sociodemographic, psychological (self-efficacy, ASKU) and clinical (somatic symptom burden, SSS-8) variables. Initially, satisfaction with information was significantly negatively associated with all three outcome variables. Fear of disease deterioration was associated with distress and depressive symptoms. After controlling for additional variables, only satisfaction with information remained an independent determinant of anxiety (β = −0.35, p < 0.001). All three outcomes were most strongly determined by somatic symptom burden (β ≥ 0.40, p < 0.001). The results of this study tentatively suggest that physical well-being overrides the relevance of some COVID-19-related stressors for oncological patients’ psychological wellbeing. Physical symptoms are strongly tied to personal wellbeing as they are associated with suffering from cancer, which might be more central to personal wellbeing than the possibility of getting infected with SARS-CoV-2. However, satisfaction with the information received seems to be important beyond physical wellbeing, as this emerged as an independent determinant of anxiety.
An exploration of the personal experiences of digital forensics analysts who work with child sexual abuse material on a daily basis: “you cannot unsee the darker side of life”
Authors: Strickland Clare , Kloess Juliane A. , Larkin Michael
Published: June 2023

Introduction

Digital forensics analysts are a specialist group of police officers who are involved in investigating cases of online child sexual exploitation and abuse (CSEA), and identifying and classifying child sexual abuse material (CSAM) according to levels of severity, respectively. The existing literature that has examined this phenomenon suggests that this group of police officers are at greater risk of psychological harm as a result of being exposed to CSAM, and that working with this type of material has the potential to significantly affect their mental health and wellbeing.

Methods

The study presented here used Interpretative Phenomenological Analysis (IPA) to explore digital forensics analysts’ personal experiences of working in this role, and with CSAM, on a daily basis, as well as how they feel this has impacted on them, and how they manage this. Seven digital forensics analysts from a specialist unit in the UK took part in semi-structured, in-person interviews.

Results

Three themes were identified, namely: (i) Once you know you cannot unknow, (ii) Constant struggle to decompress, and (iii) The ups and downs of working as a digital forensics analyst. Participants talked about the difficulty of escaping the reality of the sheer prevalence of CSEA, and that working as a digital forensics analyst ultimately takes a toll on one’s mental health and wellbeing.

Discussion

As a result of undertaking this work on a daily basis, participants reported experiencing symptoms comparable to compassion fatigue, secondary traumatic stress, and burnout, and reflected about the long-term or irreversible psychological effect that working in this role may have. Findings are discussed in relation to theoretical and practical implications, as well as directions for future research.
Ultraviolet light affects the color vocabulary: evidence from 834 languages
Authors: Dediu Dan
Published: June 2023

It has been suggested that people living in regions with a high incidence of ultraviolet light, particularly in the B band (UV-B), suffer a phototoxic effect during their lifetime. This effect, known as lens brunescence, negatively impacts the perception of visible light in the “blue” part of the spectrum, which, in turn, reduces the probability that the lexicon of languages spoken in such regions contains a word specifically denoting “blue.” This hypothesis has been recently tested using a database of 142 unique populations/languages using advanced statistical methods, finding strong support. Here, this database is extended to 834 unique populations/languages in many more language families (155 vs. 32) and with a much better geographical spread, ensuring a much better representativity of the present-day linguistic diversity. Applying similar statistical methods, supplemented with novel piecewise and latent variable Structural Equation Models and phylogenetic methods made possible by the much denser sampling of large language families, found strong support for the original hypothesis, namely that there is a negative linear effect of UV-B incidence on the probability that a language has a specific word for “blue.” Such extensions are essential steps in the scientific process and, in this particular case, help increase our confidence in the proposal that the environment (here, UV-B incidence) affects language (here, the color lexicon) through its individual-level physiological effects (lifetime exposure and lens brunescence) amplified by the repeated use and transmission of language across generations.
A pilot study of a modification EAT-26 questionnaire for screening pathological eating behavior in competitive athletes
Authors: Stackeová Daniela , Barešová Tereza , Přibylová Barbora
Published: June 2023

This study deals with pathological forms of eating behavior and disorders of athletes with the aim to verify a newly created questionnaire method focused on their screening. First, a detailed analysis of one of the most frequently used methods, EAT-26, was carried out, which was subsequently reworked into a newly created questionnaire that should meet the criteria for application to a group of competitive athletes. This new questionnaire was then verified on a group of athletes in risky sports disciplines. It was distributed among athletes of aesthetic sports, specifically among aerobics (gymnastic, sport, and fitness), gymnastics (modern and sport), professional dance, figure skating, and bodybuilding/fitness (classic bodybuilding, bikini fitness, and men’s physique). In total, 100 respondents, 79 women and 21 men, with 20 persons from each sport branch, aged 16–26, participated in the research. The main results of the research investigation were determined using factor analysis, which yielded positive results. Five strong factors (dietary control, body weight control, training obsession, appetite, and calorie counting) were identified, which can be defined as common and well-known characteristics in the eating and training regime of competitive athletes. At the same time, the factors found can be defined as essential factors influencing the emergence of disturbed eating behavior or the later development of an eating disorder. Compared to the original EAT-26, the point score was adjusted, and its critical value was determined at 57 points. Of the respondents, 33%, i.e., 33 out of a possible 100, achieved this value or above. Respondents with a point score of 57 and above were found in every sport tested. Of the 33 respondents reaching this point limit, 6% were in aerobics, 24% in gymnastics, 15% in professional dance, 27% in figure skating, and 27% in bodybuilding/fitness. Respondents from the bodybuilding and fitness sports sector achieved the highest number of points on average and those were the only ones who exceeded the threshold of 57 points on average. The results of the work correspond with the opinion of many experts that the sports environment is ideal for covering up disturbed eating behavior or eating disorders, and diagnosis in this environment is difficult.
Contextualizing the tone of the operating room in practice: drawing on the literature to connect the dots
Authors: Lia Hillary , Hammond Mobilio Melanie , Rudzicz Frank , Moulton Carol-anne
Published: June 2023

The study of teamwork in the operating room has made significant strides in uncovering key constructs which shape safe and effective intraoperative care. However, in recent years, there have been calls to understand teamwork in the operating room more fully by embracing the complexity of the intraoperative environment. We propose the construct of tone as a useful lens through which to understand intraoperative teamwork. In this article, we review the literature on culture, shared mental models, and psychological safety, linking each to the construct of tone. By identifying tone as a theoretical orientation to demonstrate the overlap between these concepts, we aim to provide a starting point for new ways to understand intraoperative team dynamics.
Perceiving animacy from kinematics: visual specification of life-likeness in simple geometric patterns
Authors: Parovel Giulia
Published: June 2023

Since the seminal work of Heider and Simmel, and Michotte’s research, many studies have shown that, under appropriate conditions, displays of simple geometric shapes elicit rich and vivid impressions of animacy and intentionality. The main purpose of this review is to emphasize the close relationship between kinematics and perceived animacy by showing which specific motion cues and spatiotemporal patterns automatically trigger visual perceptions of animacy and intentionality. The animacy phenomenon has been demonstrated to be rather fast, automatic, irresistible, and highly stimulus-driven. Moreover, there is growing evidence that animacy attributions, although usually associated with higher-level cognition and long-term memory, may reflect highly specialized visual processes that have evolved to support adaptive behaviors critical for survival. The hypothesis of a life-detector hardwired in the perceptual system is also supported by recent studies in early development and animal cognition, as well as by the issue of the “irresistibility” criterion, i.e., the persistence of animacy perception in adulthood even in the face of conflicting background knowledge. Finally, further support for the hypothesis that animacy is processed in the earliest stages of vision comes from recent experimental evidence on the interaction of animacy with other visual processes, such as visuomotor performance, visual memory, and speed estimation. Summarizing, the ability to detect animacy in all its nuances may be related to the visual system’s sensitivity to those changes in kinematics – considered as a multifactorial relational system - that are associated with the presence of living beings, as opposed to the natural, inert behavior of physically constrained, form-invariant objects, or even mutually independent moving agents. This broad predisposition would allow the observer not only to identify the presence of animates and to distinguish them from inanimate, but also to quickly grasp their psychological, emotional, and social characteristics.
Intranasal esketamine as therapeutic option: a case report of an adolescent with treatment resistant depression
Authors: Skala Katrin , Doganay Kamer , Eder Harald , Mairhofer Dunja , Neubacher Katrin , Plener Paul L.
Published: June 2023

Depression is among the most common mental health disorders worldwide and treatment resistant depression (TRD) represents a major challenge for both patients and clinicians. In recent years ketamine has received attention as an antidepressant agent, demonstrating promising results in TRD in adults. To date, few attempts have been made in treating adolescent TRD with ketamine and none have used intranasal application. This paper discusses a case of a 17-year-old female adolescent suffering from TRD who underwent treatment with intranasal esketamine application (Spravato 28 mg). As symptoms showed clinically insignificant improvement despite modest gains in objective assessments (GAF, CGI, MADRS), treatment was prematurely discontinued. However, the treatment was tolerable and side effects were scarce and mild. Although this case report does not demonstrate clinical effectiveness, ketamine may nonetheless be a promising substance in treating TRD in other adolescents. Questions regarding the safety of ketamine use in the rapidly developing brains of adolescents still remain unanswered. To further explore the potential benefits of this treatment method a short term RCTs for adolescents with TRD is recommended.
Impact of different interventions on preventing suicide and suicide attempt among children and adolescents in the United States: a microsimulation model study
Authors: Zhang Chengchen , Zafari Zafar , Slejko Julia F. , Camelo Castillo Wendy , Reeves Gloria M. , dosReis Susan
Published: June 2023

Introduction

Despite considerable investment in suicide prevention since 2001, there is limited evidence for the effect of suicide prevention interventions among children and adolescents. This study aimed to estimate the potential population impact of different interventions in preventing suicide-related behaviors in children and adolescents.

Methods

A microsimulation model study used data from national surveys and clinical trials to emulate the dynamic processes of developing depression and care-seeking behaviors among a US sample of children and adolescents. The simulation model examined the effect of four hypothetical suicide prevention interventions on preventing suicide and suicide attempt in children and adolescents as follows: (1) reduce untreated depression by 20, 50, and 80% through depression screening; (2) increase the proportion of acute-phase treatment completion to 90% (i.e., reduce treatment attrition); (3) suicide screening and treatment among the depressed individuals; and (4) suicide screening and treatment to 20, 50, and 80% of individuals in medical care settings. The model without any intervention simulated was the baseline. We estimated the difference in the suicide rate and risk of suicide attempts in children and adolescents between baseline and different interventions.

Results

No significant reduction in the suicide rate was observed for any of the interventions. A significant decrease in the risk of suicide attempt was observed for reducing untreated depression by 80%, and for suicide screening to individuals in medical settings as follows: 20% screened: −0.68% (95% credible interval (CI): −1.05%, −0.56%), 50% screened: −1.47% (95% CI: −2.00%, −1.34%), and 80% screened: −2.14% (95% CI: −2.48%, −2.08%). Combined with 90% completion of acute-phase treatment, the risk of suicide attempt changed by −0.33% (95% CI: −0.92%, 0.04%), −0.56% (95% CI: −1.06%, −0.17%), and −0.78% (95% CI: −1.29%, −0.40%) for reducing untreated depression by 20, 50, and 80%, respectively. Combined with suicide screening and treatment among the depressed, the risk of suicide attempt changed by −0.27% (95% CI: −0.dd%, −0.16%), −0.66% (95% CI: −0.90%, −0.46%), and −0.90% (95% CI: −1.10%, −0.69%) for reducing untreated depression by 20, 50, and 80%, respectively.

Conclusion

Reducing undertreatment (the untreated and dropout) of depression and suicide screening and treatment in medical care settings may be effective in preventing suicide-related behaviors in children and adolescents.
Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population
Authors: Sun Dongren , Song Mingyu , Zeng Chang , Chen Hengshu , Zhang Jingyuan , Liu Fan , Luo Shihang , Liao Qiao , Xiao Yeqing , Xu Weiye , Zeng Danfeng , Tan Zheren , Tian Fafa , Huang Xia
Published: June 2023

Objective

To investigate the relationship between single nucleotide polymorphisms (SNPs) related to vitamin D (VitD) metabolism and post-stroke depression (PSD) in patients with ischemic stroke.

Methods

A total of 210 patients with ischemic stroke were enrolled at the Department of Neurology in Xiangya Hospital, Central South University, from July 2019 to August 2021. SNPs in the VitD metabolic pathway (VDR, CYP2R1, CYP24A1, and CYP27B1) were genotyped using the SNPscan™ multiplex SNP typing kit. Demographic and clinical data were collected using a standardized questionnaire. Multiple genetic models including dominant, recessive, and over-dominant models were utilized to analyze the associations between SNPs and PSD.

Results

In the dominant, recessive, and over-dominant models, no significant association was observed between the selected SNPs in the CYP24A1 and CYP2R1 genes and PSD. However, univariate and multivariate logistic regression analysis revealed that the CYP27B1 rs10877012 G/G genotype was associated with a decreased risk of PSD (OR: 0.41, 95% CI: 0.18–0.92, p = 0.030 and OR: 0.42, 95% CI: 0.18–0.98, p = 0.040, respectively). Furthermore, haplotype association analysis indicated that rs11568820-rs1544410-rs2228570-rs7975232-rs731236 CCGAA haplotype in the VDR gene was associated with a reduced risk of PSD (OR: 0.14, 95% CI: 0.03–0.65, p = 0.010), whereas no significant association was observed between haplotypes in the CYP2R1 and CYP24A1 genes and PSD.

Conclusion

Our findings suggest that the polymorphisms of VitD metabolic pathway genes VDR and CYP27B1 may be associated with PSD in patients with ischemic stroke.
Nurses’ experiences of a screening and associated psychosomatic consultation service for mental comorbidities in somatic care inpatients – a qualitative study
Authors: Braunschneider Lea-Elena , Seiderer Johannes , Loeper Siobhan , Löwe Bernd , Kohlmann Sebastian
Published: June 2023

Background

Screening for mental comorbidities and related liaison service can reduce hospital length of stay in somatic hospital care. To develop, test and sustain such health care services, stakeholder feedback is required. One of the most important stakeholders in general hospital care and health care processes are nurses.

Aim

The aim of this study is to explore nurses’ experiencess on standardized nurse-led screening for mental comorbidities and associated psychosomatic consultation service in routine somatic inpatient care.

Method

Semi-structured qualitative interviews were conducted with 18 nurses that were involved in a nurse-led screening service for mental comorbidities on internal medicine or dermatological wards. Data were analyzed using thematic analysis.

Results

Eight thematic groups were developed. On the one hand, participants reported benefits of screening: mental health education, general mental health awareness, holistic treatment approach, opportunity to build rapport with patients and reduction in workload. On the other hand, possible psychological effects of the intervention, reasons why patients may not want to be referred and application requirements to facilitate delivery were identified. None of the nurses opposed screening and associated psychosomatic consultation service.

Conclusion

All nurses endorsed the screening intervention and considered it meaningful. Nurses particularly emphasized the potential for holistic patient care and nurses’ improved skills and competencies, but partly critizised current application requirements.

Relevance to clinical practice

This study adds on existent evidence on nurse-led screening for mental comorbidities and associated psychosomatic consultation service by emphasizing its potential to improve both patient care as well as nurses’ perceived self-efficacy and job satisfaction. To take full advantage of this potential, however, usability improvements, regular supervision, and ongoing training for nurses need to be considered.
Rasch analyses of the Quick Inventory of Depressive Symptomatology Self-Report in neurodegenerative and major depressive disorders
Authors: Vaccarino Anthony L. , Black Sandra E. , Gilbert Evans Susan , Frey Benicio N. , Javadi Mojib , Kennedy Sidney H. , Lam Benjamin , Lam Raymond W. , Lasalandra Bianca , Martens Emily , Masellis Mario , Milev Roumen , Mitchell Sara , Munoz Douglas P. , Sparks Alana , Swartz Richard H. , Tan Brian , Uher Rudolf , Evans Kenneth R.
Published: June 2023

Background

Symptoms of depression are present in neurodegenerative disorders (ND). It is important that depression-related symptoms be adequately screened and monitored in persons living with ND. The Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) is a widely-used self-report measure to assess and monitor depressive severity across different patient populations. However, the measurement properties of the QIDS-SR have not been assessed in ND.

Aim

To use Rasch Measurement Theory to assess the measurement properties of the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) in ND and in comparison to major depressive disorder (MDD).

Methods

De-identified data from the Ontario Neurodegenerative Disease Research Initiative (NCT04104373) and Canadian Biomarker Integration Network in Depression (NCT01655706) were used in the analyses. Five hundred and twenty participants with ND (Alzheimer’s disease or mild cognitive impairment, amyotrophic lateral sclerosis, cerebrovascular disease, frontotemporal dementia and Parkinson’s disease) and 117 participants with major depressive disorder (MDD) were administered the QIDS-SR. Rasch Measurement Theory was used to assess measurement properties of the QIDS-SR, including unidimensionality and item-level fit, category ordering, item targeting, person separation index and reliability and differential item functioning.

Results

The QIDS-SR fit well to the Rasch model in ND and MDD, including unidimensionality, satisfactory category ordering and goodness-of-fit. Item-person measures (Wright maps) showed gaps in item difficulties, suggesting poor precision for persons falling between those severity levels. Differences between mean person and item measures in the ND cohort logits suggest that QIDS-SR items target more severe depression than experienced by the ND cohort. Some items showed differential item functioning between cohorts.

Conclusion

The present study supports the use of the QIDS-SR in MDD and suggest that the QIDS-SR can be also used to screen for depressive symptoms in persons with ND. However, gaps in item targeting were noted that suggests that the QIDS-SR cannot differentiate participants falling within certain severity levels. Future studies would benefit from examination in a more severely depressed ND cohort, including those with diagnosed clinical depression.
Anxiety and posttraumatic stress in post-acute sequelae of COVID-19: prevalence, characteristics, comorbidity, and clinical correlates
Authors: Ferrando Stephen J. , Lynch Sean , Ferrando Nicole , Dornbush Rhea , Shahar Sivan , Klepacz Lidia
Published: June 2023

Background

Anxiety and post-traumatic stress symptoms have been reported in association with acute and post-acute sequelae of COVID-19 (PASC).

Purpose

This study aimed to document the cross-sectional prevalence, characteristics and clinical correlates of anxiety and post-traumatic stress in a study of neuropsychiatric sequelae of COVID-19.

Method

75 participants recruited from a post-COVID-19 recovery program and the community were assessed for sociodemographic, medical, psychiatric, and neurocognitive symptoms and performance. The generalized anxiety questionnaire-7 (GAD-7) and post-traumatic stress disorder questionnaire for DSM5 (PCL5) were utilized to measure anxiety and PTSD symptoms. Established cutoff scoring for the GAD-7 and algorithm-based scoring of the PCL5 were utilized to determine clinically significant anxiety symptoms and PTSD, respectively.

Results

The cohort was 71% female, 36% ethnic minority, with the main age of 43.5 years, 80% employment, 40% with the prior psychiatric treatment history and 2/3 seeking post-COVID care for PASC. Clinically significant anxiety symptoms were found in 31% and PTSD was found in 29% of the cohort. Nervousness and excessive worry were the most prominent anxiety symptoms, while changes in mood/cognition and avoidance were most frequent in PTSD. There was a high degree of comorbidity between clinically significant anxiety symptoms, PTSD, depression and fatigue. In logistic regression, acute COVID illness severity, prior psychiatric history, and memory complaints (but not objective neuropsychological performance) predicted clinically significant anxiety symptoms and/or PTSD.

Conclusion

Clinically significant anxiety and PTSD are found in approximately 1 of 3 individuals after COVID-19 infection. They are highly comorbid with each other as well as with depression and fatigue. All patients seeking care for PASC should be screened for these neuropsychiatric complications. Symptoms of worry, nervousness, subjective changes in mood, and cognition as well as behavioral avoidance are particularly important targets of clinical intervention.
Is befriending a valuable intervention in schizophrenia? A scoping review
Authors: Farcas Adriana , Campbell Mackenzie , Wong Charmaine , Iftene Felicia
Published: June 2023

Background

Schizophrenia is a severe, chronic mental disorder that involves disruptions in cognitive processes, emotional responsiveness, and social interactions. Psychotherapeutic and social integration practices have increasingly been added to the pharmacological treatment in an effort to improve the level of functioning and the quality of life of individuals affected by this condition. Befriending, defined as a one-on-one companionship provided by a volunteer who aims to act as an emotionally supportive liaison, is hypothesized to be an effective such intervention, offering support for building and maintaining social relationships in the community. Despite its increase in popularity and acceptance, befriending remains poorly understood and under-researched.

Methods

We performed a systematic search for studies targeting befriending either as an intervention or a controlled condition in studies on schizophrenia. Searches were performed in four databases: APA PsycInfo, Pubmed, Medline and EBSCO. The keywords “schizophrenia,” AND “befriending,” were searched for on all databases.

Results

The search yielded 93 titles and abstracts, of which 18 met the criteria for inclusion. The studies included in this review have all incorporated befriending as an intervention or a controlled condition, as per our search criteria, and aimed at depicting the value and feasibility of this intervention to address social and clinical deficits in individuals with schizophrenia.

Conclusion

The studies selected for this scoping review revealed inconsistent findings regarding the effect of befriending on overall symptoms and the subjective reporting of quality of life in individuals with schizophrenia. This inconsistency may be attributed to differences between the studies and their specific limitations.
Shorter telomere length in children with autism spectrum disorder is associated with oxidative stress
Authors: Zhang Tong , Sun Yanan , Wei Jing , Zhao Guoqiang , Hao Wenqi , Lv Zhihai , Chen Xiaohang , Liu Yanan , Wei Fengxiang
Published: June 2023

Objective

Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder caused by a complex interaction between genetic and environmental risk factors. The balance between antioxidant capacity and oxidative stress (OS) induced free radicals may be crucial during the pathophysiological development of ASD.

Methods

In this study, 96 children with ASD who met the diagnostic and statistical manual of mental disorders were collected, and the number of children in the typical development (TD) group was matched by 1:1. Digital PCR (dPCR) for telomere length (TL) expression in ASD in peripheral blood leukocytes. Urine levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) content were measured by tandem triple quadrupole mass spectrometry and corrected by urinary creatinine levels. The levels of superoxide dismutase (SOD), catalase (CAT), and capacity (AOC) were detected by kits.

Results

The TL of the ASD group was shorter than the TD group (p < 0.01) and had some accurate predictive significance for the identification of ASD (AUC = 0.632, 95% CI: 0.533–0.710, p = 0.002). Both 8-OHdG content and SOD activity in the ASD group were significantly higher than those in the TD group (p < 0.05). Shortened TL (Monofactor: 2.20 (1.22, 3.96), p = 0.009; Multifactor: 2.22 (1.22, 4.00), p = 0.008) and reduced CAT activity (Monofactor: 2.31 (1.28, 4.17), p = 0.006; Multifactor: 2.31 (1.28, 4.18), p = 0.006) are risk factors for the development of ASD, while reduced 8-OHdG content (Monofactor: 0.29 (0.14, 0.60), p = 0.001; Multifactor: 0.27 (0.13, 0.57), p = 0.001) and reduced SOD activity (Monofactor: 0.55 (0.31, 0.98), p = 0.042; Multifactor: 0.54 (0.30, 0.98), p = 0.042) are protective factors for the development of ASD.

Conclusion

In this study, TL and OS were significantly different between the ASD group and the TD group. As guanine-rich telomere sequences were likely damaged by oxygen free radicals, creating OS, which is a factor in the incidence and progression of ASDs. In conclusion, oxidative damage occurs in the bodies of children with ASD, which may lead to sustained disease progression and severe clinical manifestations. We assume that timely supplementation of antioxidants is very likely to be a potential treatment for early intervention in children with ASD. Identification and detection of OS-related biomarkers may contribute to early diagnosis and timely interventions in young patients with ASD.
Keeping kids in school: modelling school-based testing and quarantine strategies during the COVID-19 pandemic in Australia
Authors: Abeysuriya Romesh G. , Sacks-Davis Rachel , Heath Katherine , Delport Dominic , Russell Fiona M. , Danchin Margie , Hellard Margaret , McVernon Jodie , Scott Nick
Published: June 2023

Background

In 2021, the Australian Government Department of Health commissioned a consortium of modelling groups to generate evidence assisting the transition from a goal of no community COVID-19 transmission to ‘living with COVID-19’, with adverse health and social consequences limited by vaccination and other measures. Due to the extended school closures over 2020–21, maximizing face-to-face teaching was a major objective during this transition. The consortium was tasked with informing school surveillance and contact management strategies to minimize infections and support this goal.

Methods

Outcomes considered were infections and days of face-to-face teaching lost in the 45 days following an outbreak within an otherwise COVID-naïve school setting. A stochastic agent-based model of COVID-19 transmission was used to evaluate a ‘test-to-stay’ strategy using daily rapid antigen tests (RATs) for close contacts of a case for 7 days compared with home quarantine; and an asymptomatic surveillance strategy involving twice-weekly screening of all students and/or teachers using RATs.

Findings

Test-to-stay had similar effectiveness for reducing school infections as extended home quarantine, without the associated days of face-to-face teaching lost. Asymptomatic screening was beneficial in reducing both infections and days of face-to-face teaching lost and was most beneficial when community prevalence was high.

Interpretation

Use of RATs in school settings for surveillance and contact management can help to maximize face-to-face teaching and minimize outbreaks. This evidence supported the implementation of surveillance testing in schools in several Australian jurisdictions from January 2022.