bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Renessans (Iodine Complex Molecule) Safety in Human Beings: An Open-Labeled Clinical Study
Authors: Kamal Ahmad , Mahmood Asif , Zaman Muhammad , Farooq Muhammad , Nasir Bilal , Islam Nasir , Sarfraz Rai Muhammad , Zafar Nadiah , Murtaza Ghulam , Raheel Abdul-Basit , Shahid Areeba , Abid Zahra , Ahmed Sajjad
Published: October 2022

Extensive studies on evaluation of effectiveness/toxicity of different oral doses of iodine have not been explored yet. An open-labeled phase I clinical studies were conducted using iodine complex based research compound called Renessans. Study groups were observed for development of any adverse/serious adverse events and alteration in laboratory values of vital organs, TSH and T4 hormones before and after the administration of the products. Out of 31 consented individuals, 24 healthy individuals participated in the study. Rate of occurrence of mild Adverse Events (AEs) in group A was 8.3% while in Group B it was 33.33% but these Adverse Events were self-resolving. After completion of study treatment blood serum iodine was reported to 3522.88 µg/l while mean urine iodine concentration (MUIC) was greater than 2000 µg/l. Hormonal and vital organ’s testing revealed that all parameters of TSH and T4, LFT, CBC, RFT remained unaltered except from ALT-SGPT ( P-value = .006) and AST-SGOT ( P-value = .02). From all of these findings, it can be inferred that the use of Renessans formulations did not pose any sort of risk to human body and can be considered safe through this pilot study.
Familiarization with White Whole Wheat Improves Acceptability of Whole Grain-Based Baked Products Made with White Whole Wheat Among College Students
Authors: Samuel Lalitha , Wimmer Ilana , Glassberg Gila , Boyar Andrea
Published: October 2022

Research corroborates that high whole grain intake is associated with lower risk for obesity, type 2 diabetes, cardiovascular diseases, and cancers. Unfamiliarity with, and negative sensory appeal of whole grains limit voluntary food choices to increase their consumption. This study aimed to explore the effectiveness of familiarization with white whole wheat, to improve college students’ acceptability of shortened cakes, muffins, and yeast breads made with white whole wheat flour (WWWF). All-purpose flour (APF) was replaced with WWWF in standardized recipes, and the products scored by 102 college students. Independent t-test was used to analyze if sensory scores for appearance, taste, texture, and overall acceptability between APF and WWWF products were statistically significant. Before familiarization with WWWF, all three APF products scored significantly higher than whole grain counterparts ( P < .05). When participants were familiarized with health benefits and expected sensory profile of whole grain products, sensory scores for appearance, taste, and overall acceptability of WWWF products did not significantly differ from APF counterparts ( P > .05). Familiarization significantly increased overall acceptability scores of WWWF products ( P < .05). Familiarization also increased proportion of students willing to bake with WWWF. Results underscore that familiarization can improve acceptability of WWWF in baked products and students’ willingness to incorporate it in baking, with potential to stimulate dietary modifications.
Attention and expectation likely underlie temporal binding measured using the Libet Clock
Authors: Hon Nicholas
Published: October 2022

An interesting finding that has emerged in studies of the sense of agency is that of a perceived compression of the temporal interval between actions and the outcomes they produce. This is generally referred to as temporal binding. Although temporal binding has been studied using various paradigms, possibly the most popular of these is the Libet Clock task. The Libet task is also interesting because it suggests that temporal binding can be decomposed into two components, one purportedly relating to actions and the other relating to outcomes. These are termed action binding and outcome binding, respectively. In this article, I focus specifically on temporal binding revealed using the Libet Clock task and propose the idea that attention underpins the action binding effect, while outcome binding, on the other hand, is driven by the effects of expectation.
Multiple Sclerosis immunotherapies and COVID-19 mortality: an analysis of the FDA Adverse Event Reporting System
Authors: Pistor Maximilian , Hoepner Robert , Hoepner Andreas G.F. , Lin Yanan , Jung Simon , Bassetti Claudio L. , Chan Andrew , Salmen Anke
Published: October 2022

Background:

Evidence on mortality risks associated with MS-immunotherapies during the SARS-CoV2 pandemic derived thus far mainly from single country experiences.

Objective:

In this analysis, we aim to determine the frequency of COVID-19 associated fatality reports of patients receiving an MS-immunotherapy as reported to the international Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) from February 2020 to March 2021.

Methods:

In all, 1071 cases for this cross-sectional analysis were retrieved from FAERS and a multivariable logistic regression was performed. We adjusted for sex, age, region, month of report to FDA, immunotherapy-class and additionally for healthcare-system and pandemic-related metrics.

Result:

Anti-CD20 therapies (60%) followed by sphingosine-1 phosphate modulators (12%) and dimethylfumarat (10%) were reported most frequently. In 50% of the cases, MS-phenotype is not reported, relapsing MS in 35% and progressive MS in 15%. Besides older age (odds ratio [OR]: 1.1; 95% confidence interval [CI]: 1.07–1.13; p < 0.01), anti-CD20 therapies were significantly associated with a higher risk of death (OR: 4.1; 95% CI: 1.17–14.46; p = 0.03), whereas female sex was associated with a reduced mortality risk (OR: 0.4, 95% CI: 0.22–0.72; p < 0.01).

Conclusion:

Using international open access data and a multidisciplinary approach for risk prediction, we identified an increased mortality risk associated with anti-CD20 therapies, which is in line with national and multi-national cohort studies.
Charting developmental trajectories from 12 to 36 months and associated early risk and protective factors
Authors: Roe Elizabeth , Jensen Lynn , Finlay-Jones Amy , White Scott W , Wong Kingsley , Leonard Helen , Straker Leon , Downs Jenny
Published: October 2022

Aim

To investigate developmental trajectories in early childhood and predictors of class assignment.

Methods

Data were available for Gen2 infants at 12 ( n = 2275), 24 ( n = 1845) and 36 ( n = 2110) months of age in the Raine Study. Latent growth class analysis was used to identify developmental trajectories based on the Ages and Stages Questionnaire. Multivariate logistic regression analyses were used to estimate associations between foetal growth restriction, gestational age, child biological sex, breast feeding, parental age, socioeconomic factors and developmental trajectories.

Results

Two groups of infants were identified, one typically performing and one poorer performing. Being born early-term, pre-term and male were associated with poorer development. Not exposed to breastfeeding was associated with the lower trajectories in the adaptive and personal-social domains.

Conclusions

Developmental surveillance and advice for early-term infants should be considered. Findings highlight the continued need to support and promote breastfeeding as a protective mechanism for child development.
The Effect of Nanocurcumin Supplementation on Protein C, Partial Thromboplastin Time, Transforming Growth Factor-β1, and Simplified Acute Physiology Score II in Patients With Systemic Inflammatory Response Syndrome: A Randomized Clinical Trial
Authors: Zarei Elham , Tarighat-Esfanjani Ali , Mahmoodpoor Ata , Karimi Arash
Published: October 2022

Systemic inflammatory response syndrome (SIRS) is a general inflammation that involves many patients’ organs in intensive care units and significantly affects the risk of morbidity and mortality. This study aimed to investigate the effect of nanocurcumin on protein C, partial thromboplastin time (PTT), transforming growth factor-β1 (TGF-β1), and simplified acute physiology score II (SAPS II) in patients with SIRS. In this randomized, clinical trial, 40 SIRS-positive patients were randomly assigned to the intervention group who received 160 mg/day of nanocurcumin and the control group that received routine treatment for 10 days. Before, the 5th and 10th days of the study, the SAPS II questionnaire was completed, and protein C, PTT, and TGF-β1 levels were measured. At the end of the study, the PTT levels in the intervention and control groups increased and decreased, respectively. However, the significant increase of protein C levels was shown only in the intervention group. SAPS II scores were also decreased significantly only in the intervention group. There was no significant difference in serum levels of TGF-β1 in both groups. According to the results of this study, supplementation with nanocurcumin can decrease the SAPS II and improve the coagulation status in patients with SIRS.
Built Environment Design Interventions at the Exits of Secured Dementia Care Units: A Review of the Empirical Literature
Authors: Anderson Diana C. , Kota Shalini S. , Yeh Leigh , Budson Andrew E.
Published: October 2022

Purpose:

To review evidence around design interventions that influence exiting attempts in dementia care units, informing architectural and clinical practice.

Background:

Built environment design is recognized as important in the care and management of responsive behaviors for those living with Alzheimer’s disease and other dementias in secured dementia care units (e.g., exiting attempts, agitation). The repetitious behavior of “walking with purpose” (previously termed wandering) in those with dementia has influenced safety-related architectural design components of dementia care units that decrease exiting attempts. Empirical literature addressing design interventions to prevent exiting for those with dementia is lacking and outdated.

Methods:

We sought to describe known design techniques through a topical analysis of experimental studies. A thorough search for empirical studies that assessed interior design interventions at exit doors within dementia care units was undertaken. The review included an extensive search for existing literature and a screening of each study identified for its relevance, quality, and applicability.

Results:

The experimental studies included in the review collectively assessed five interior design interventions at egress doorways: implementing horizontal and vertical floor grid patterns, mirrors, murals, conditioning responses to color cues, and camouflaging door hardware or vision panels. Why empirical studies have not continued more recently as built environment trends have shifted toward promoting meaningful and purposeful movement through design are considered. Advances in our understanding around the pathophysiology of dementia which might affect future design interventions related to egress are also identified.

Conclusion:

The built environment is an important part of dementia care, and further prospective research is needed on the role of design interventions in the context of exiting attempts within secured units and subsequent behavior outcomes.
Medial Ankle Instability: Review of Anatomy, Evaluation, and Treatment
Authors: Gopinath Rohan , Pigott Matthew , Lindsey Benjamin , Finney Fred T. , Holmes James R. , Walton David M. , Talusan Paul G.
Published: October 2022

The medial ankle ligamentous complex, which includes the deltoid, talocalcaneal, and calcaneonavicular ligaments, functions to provide stability to the medial ankle. Injuries to the deltoid ligament can lead to medial-sided ankle pain, subsequent instability, and posttraumatic osteoarthritis given the altered biomechanics of the ankle joint. After completing a thorough physical examination, imaging modalities such as stress radiographs and magnetic resonance imaging can be used to confirm the diagnosis. Acute injuries to the deltoid ligament should be managed conservatively with a short course of immobilization. For patients with continued pain and instability following a regimen of nonoperative management, surgical intervention can be considered. Primary repair using suture anchor fixation to the medial malleolus can be utilized if sufficient tissue remains. However, if reconstruction is necessitated, autograft or allograft can be utilized in several described techniques.

Levels of Evidence: Therapeutic
Contrasting Cases of HIV Vasculopathy Associated Fusiform Aneurysms
Authors: Kyle Kevin , Maher Mary , Achhra Amit C. , Venna Nagagopal
Published: October 2022

Background

Human Immunodeficiency Virus (HIV) vasculopathy encompasses the development of aneurysms, stenosis and vessel occlusions. Intracranial fusiform aneurysms in Human Immunodeficiency Virus (HIV) were originally described in children; however, HIV-associated aneurysms are increasingly recognized in adults. Purpose: We present two cases to highlight the spectrum of severity and outline instructive clinical courses.

Results

Case one is a 52-year-old woman with HIV, Acquired Immunodeficiency Syndrome (AIDS)-defining progressive multifocal leukoencephalopathy (PML) and an 18 years course of cerebral aneurysms, aneurysm thrombosis and the development of right middle cerebral artery (MCA) moyamoya pattern collaterals. Case two is a 55-year-old man with AIDS-defining cerebral toxoplasmosis, complicated by IRIS and anterior and posterior circulation fusiform aneurysm formation. Conclusions: The combination of both fusiform abnormalities and Moyamoya, discussed in our first case has not been previously described. In comparison, our second case actually demonstrated improvement in vasculopathy after nine-months of antiretroviral therapy (ART) adherence.
National Patterns and Outcomes of Neurologist Care in Acute Ischemic Stroke
Authors: Moody Kate A. , Maillie Luke , Dhamoon Mandip S.
Published: October 2022

Background & Purpose

Specialist care of acute ischemic stroke patients has been associated with improved outcomes but is not well-characterized. We sought to elucidate the involvement and influence of neurologists on acute ischemic stroke care.

Methods

Using 100% Medicare datasets, index acute ischemic stroke admissions from 2016-2018 were identified with International Classification of Diseases, 10th Revision codes. Neurologists were identified by NPI code. Neurologist involvement in care was defined as: “neurologist involved in care”; “hospital with a neurologist”; and “percent of acute ischemic stroke treated by neurologist.” Adjusted logistic regression models summarized exposure to neurologists and their association with outcomes (inpatient mortality, good outcome, and 30-day readmission).

Results

Among 647838 index AIS admissions from 2016-2018, 15.6% included a neurologist involved in care, associated with receiving intravenous thrombolysis (19.1% vs 6.5%), endovascular thrombectomy (13.2% vs 1.4%), treatment at a teaching hospital (87.7% vs 55.5%), and treatment at a hospital in the highest volume quartile (95.3% vs 75.6%). Of 4797 hospitals, 36.1% had a neurologist, among which the mean percent of admissions treated by a neurologist was 14.7% (SD 24.4). Neurologist involvement was associated with increased inpatient mortality (OR 1.81; 95% CI 1.75-1.86), decreased odds of a good outcome (OR .92; 95% CI .90-.93), and increased 30-day readmission (OR 1.04; 95% C: 1.01-1.06).

Conclusions

The minority of acute ischemic stroke admissions among the elderly in the US are treated by neurologists. Neurologist involvement in care is associated with worse outcomes, possibly from the allocation of severe cases to neurologists.
Circulating T Cell Subsets and ILC2s are Altered in Patients With Chronic Rhinosinusitis With Nasal Polyps After Dupilumab Treatment
Authors: Matsuyama Toshiyuki , Takahashi Hideyuki , Tada Hiroe , Chikamatsu Kazuaki
Published: October 2022

Background

Chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly associated with type 2 inflammation and is often unmanageable, regardless of the treatment. Dupilumab, a monoclonal antibody targeting the interleukin (IL)-4 receptor alpha to inhibit IL-4 and IL-13 signaling, has recently been shown to significantly improve the condition of patients with CRSwNP. However, the mechanisms underlying this response to dupilumab are not yet fully understood.

Objective

We sought to examine whether circulating T cell subset proportions and their functions are altered by dupilumab treatment.

Methods

We first investigated the proportion of circulating T cell subsets and group 2 innate immune cells (ILC2s) in patients with CRSwNP treated with dupilumab using mass and flow cytometry. We then assessed cytokine gene expression and cytokine production in peripheral blood mononuclear cells (PBMCs) using quantitative reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).

Results

The type 2 T helper (Th2) cell proportion significantly decreased after dupilumab treatment, whereas that of type 1 T helper (Th1) cells increased. Moreover, programmed death-1 (PD-1) expression in regulatory T (Treg) cells was significantly reduced. The proportion of ILC2s significantly increased after dupilumab treatment. Unfortunately, neither cytokine gene expression nor cytokine production in PBMCs showed significant changes.

Conclusions

Our findings suggest that in CRSwNP patients treated with dupilumab, Th2, Treg, and ILC2 cells, which regulate type 2 inflammation, are modulated in the peripheral circulation. Further analysis of circulating immune cells could provide novel insights into understanding the pathophysiologic mechanisms of dupilumab and the development of tailored therapeutic strategies for patients with CRSwNP.
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and cancer risk: an updated meta-analysis of observational studies
Authors: Shin Kayeong , Yang Jiwoo , Yu Yeuni , Son Eunjeong , Kim Kihun , Kim Yun Hak
Published: October 2022

Introduction:

Debate on the association between the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) and the risk of developing cancer has been ongoing for decades. This study aimed to generate reliable results by analysing observational studies published in the decade after our last meta-analysis was conducted.

Methods:

We searched Embase and Medline databases on 21 January 2021 for cohort and case-control studies. Two researchers independently reviewed the literature and assessed the title and abstract of each publication. The I2 statistic used to evaluate the heterogeneity of the effect measures. Risk of bias was qualitatively assessed using the Newcastle–Ottawa scale.

Results and discussion:

We included an additional 16 cohort, 6 nested case-control, and 9 conventional case-control studies in the updated analysis. Overall HRs decreased, while overall relative risks increased.

Conclusion:

Our results show some protective effects through the hazard ratio and some detrimental effects through the relative risk. Large-scale investigations of cohorts followed up for decades are needed to clarify association.

Plain Language Summary

Introduction: Two types of drug, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), have been linked to the risk of developing cancer. We performed a meta-analysis by aggregating individual studies looking into the cancer risk of ACEIs and ARBs. Methods: We searched for articles on Embase and Medline databases until 21 January, 2021. Two researchers independently reviewed the literature and assessed the title and abstract of each publication. Results: Overall, the hazard ratio showed less than 1, while the relative risks showed higher than 1. Conclusion: Our results show some protective effects through the hazard ratio and some detrimental effects through the relative risk. Evidence supporting the risk of developing cancer is insufficient to prevent prescribing ACEIs or ARBs for patients with high blood pressure.
Text messaging to increase patient engagement in a large health care for the homeless clinic: Results of a randomized pilot study
Authors: Kershaw Karyn , Martelly Lisa , Stevens Cassidy , McInnes D. Keith , Silverman Allie , Byrne Thomas , Aycinena Diana , Sabin Lora L. , Garvin Lynn A. , Vimalananda Varsha G. , Hass Robert
Published: October 2022

Objectives

To assess the feasibility and effectiveness of text messaging to increase outpatient care engagement and medication adherence in an urban homeless population in Boston.

Methods

Between July 2017 and April 2018, 62 patients from a clinic serving a homeless population were sent automated text messages for four months. Messages were either appointment reminders and medication adherence suggestions (intervention group) or general health promotion messages (control group). Medical records were reviewed to evaluate appointment keeping, emergency room (ER) use, and hospitalizations. Pre- and post-surveys were administered to measure self-reported medication adherence.

Results

No significant differences were found in inpatient or outpatient care between the intervention and control groups, though differences in no-show rates and medication adherence approached significance. Appointment no-show rates were 21.0% vs. 30.6% ( p = 0.08) for intervention and control, respectively, and rates of completed appointments were 65.8% vs. 56.7% ( p = 0.12). Mean ER visits were 3.86 vs 2.33 ( p = 0.16) for intervention and control groups, and mean inpatient admissions were 0.6 versus 1.24 ( p = 0.42). Self-reported medication adherence increased from 8.27 to 9.84 in intervention participants, compared to an increase from 8.27 to 8.68 in control participants ( p = 0.07), on a 1–11 scale.

Conclusions

Text messaging showed the potential to improve patient engagement in care and medication adherence in an urban homeless population (findings approaching but not achieving statistical significance). Work is needed to enhance the effectiveness of text-messaging interventions, which may involve increasing ease of use for mobile phones and texting apps, and addressing high rates of phone theft and loss.
Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021
Authors: Zhao Jie , Mao Jie , Tan Jing
Published: October 2022

Objective

Extended reality technologies (e.g. virtual reality (VR), augmented reality (AR) and mixed reality (MR)) are gaining popularity in sports owing to their unique advantages. This study aims to analyse the progress of the application of extended reality technology in sports and reveal its cooperative features, research hotspots and development trends.

Methods

We searched the literature in the Web of Science Core Collection (WoSCC) database within the period 2000 to 2021 and conducted a bibliometric analysis. The analysis methods included statistical, co-occurrence, hierarchical clustering and social network analyses.

Results

A total of 340 articles were gathered. The literature related to its research showed an increasing trend over time. The paper collaboration rate was 90.88% (309/340 papers), and the degree of author collaboration was 3.96 (1345/340). VR was found to be the most productive journal, and Queen's University Belfast was the most productive institution. The United States, China and the United Kingdom were the three main contributors to the field. The foundational themes in sports extended reality research were (i) sports games and extended reality systems, (ii) virtual simulation devices and artificial intelligence, (iii) sports training and performance and (iv) age-appropriate physical activity, sports rehabilitation and physical education.

Conclusion

The level of author collaboration was low, but the degree of author collaboration is largely on the rise. The closeness of the collaboration between institutions and countries was also low. In addition, the subject of sport extended reality is relatively fragmented. Therefore, more research is needed to strengthen it in the future.
Left Ventricular Pseudoaneurysm: Unexpected Sequel of Tamponade-Complicated Infectious Pericarditis in Infancy
Authors: Rakha Shaimaa , Elgamal Mohamed-Adel F. , Sobh Donia M. , Elmarsafawy Hala
Published: October 2022

Left ventricular pseudoaneurysm (LV-PsA) is a critical finding that could result in a fatal outcome. It may complicate myocardial infarction, cardiac surgery, trauma, or endocarditis but rarely follows pericarditis. We report a case of infectious pericarditis complicated by pericardial tamponade in an infant. After effusion drainage and medical therapy, a large LV-PsA was detected. Successful closure of the pseudoaneurysm᾽s neck was accomplished using a Gore-tex patch.
Primary Cervical Disc Arthroplasty Among Medicare Beneficiaries Versus Alternative Payers: Is It Time to Consider Nationwide Coverage?
Authors: Gordon Adam M , Golub Ivan J , Lam Aaron W , Ng Mitchell K , Saleh Ahmed
Published: October 2022

Study Design

Retrospective cohort study.

Objectives

As of 2022, the Centers for Medicare and Medicaid Services does not provide nationwide coverage for cervical disc arthroplasty (CDA). The aim was to determine whether Medicare beneficiaries have differences in: (1) lengths of stay (LOS); (2) complications; (3) readmissions; and (4) costs of care.

Methods

Using the 2010 to 2020 PearlDiver database, we queried patients undergoing primary CDA for degenerative disc pathology. Study groups patients were those undergoing CDA with Medicare coverage (n = 1467); patients without Medicare coverage were the comparison cohort (n = 15,389). Endpoints were to compare demographics and comorbidities within the Elixhauser comorbidity index (ECI), LOS, 90-day complications, 90-day readmissions, and 90-day reimbursements. A multivariate logistic regression was used to calculate odds (OR) of medical complications and readmissions within 90-days. A P-value less than .003 was significant.

Results

Patients with Medicare coverage undergoing CDA had higher mean ECI compared to alternative payers (5.24 vs 3.26; P < .0001). Mean LOS was significantly higher for Medicare beneficiaries (2.20 vs 1.76 days; P < .010). There was no significant differences in odds of all medical complications (OR: 1.19, 95% CI: .98-1.44; P = .069) or readmission rates (1.77% vs 1.33%, OR:0.82, 95% CI: .50-1.29; P = .417) within 90-days following the index procedure among Medicare beneficiaries vs alternative payers. Non-Medicare beneficiaries had higher 90-day reimbursements compared to Medicare beneficiaries ($6,700 vs $7,086, P < .001).

Conclusions

Medicare beneficiaries despite having slightly longer lengths of stay did not have higher rates of medical complications or readmissions. Surgeons and policy makers may use this data to consider alternative treatments in Medicare patients.
Impacts of COVID-19 on HIV/AIDS-Related Services in California
Authors: Koester Kimberly A. , Fuller Shannon M. , Steward Wayne T. , Arnold Emily A.
Published: October 2022

The degree to which COVID-19 has disrupted the advances in reducing new HIV infections and preventing AIDS-related deaths is unknown. We present findings related to the effect COVID-19 had on HIV, sexual health and harm reduction service delivery in the state of California. We conducted a qualitative rapid assessment with health care providers, as well as representatives from non-medical support service agencies serving clients living with HIV in a range of counties in California. Some organizations adapted fairly easily while others struggled or were unable to adapt at all. Clinics were better positioned than community-based organizations to accommodate COVID restrictions and to quickly reestablish services. Influential forces that softened or calcified the hardships created by COVID-19 included influx of funding, flexibility in managing funds, networking and relationships, and workforce vulnerabilities. These data clearly suggest that an enhanced level of flexibility within funding streams and reporting requirements should be continued.
War and decolonization in Ukraine
Authors: Barkawi Tarak
Published: October 2022

This essay considers the Ukraine conflict as a war of decolonization. It understands decolonization as a practice of world order making that creates international relations out of imperial relations. What does such a perspective tell us about the conflict in Ukraine and its implications for world politics?
About the King of Han-Winu (漢委奴國王) on the gold seal
Authors: Deno Fumiri
Published: October 2022

This paper discusses the text of a gold seal Hanweinu guowang 漢委奴國王 and points out why the traditional theories about ‘the king of Na (奴) of Wa (委)’ and ‘King of Ito (伊都)’ are wrong. Next, the content of the gold seal will be interpreted from the historical aspect and the study of Chinese characters, and the author will prove that ‘委奴’ is synonymous with ‘倭人’, which is the state name of the Japanese archipelago.
Botox: Should It Ever Be Used? (Surgery Perspective)
Authors: O’Connor Amber L. , Wood Stephanie G.
Published: October 2022

Botox was first described for its use in achalasia in 1995, demonstrating that it could be safely used to temporarily improve the outflow obstruction and relieve patient symptoms such as dysphagia, regurgitation and chest pain for several months. Though highly effective, Botox loses efficacy long-term compared to other endoscopic or surgical treatments, with the majority requiring repeated injections. Therefore, Botox is not favored as a long-term treatment strategy for patients with otherwise surgically treatable achalasia. It instead serves as an alternative to bridge patients to definitive treatment, to treat poor surgical candidates, and to confirm achalasia diagnosis in complex patients.
The vulnerability of tropical peatlands to oil and gas exploration and extraction
Authors: Lawson Ian T , Honorio Coronado Eurídice N , Andueza Luis , Cole Lydia , Dargie Greta C , Davies Althea L , Laurie Nina , Okafor-Yarwood Ifesinachi , Roucoux Katherine H , Simpson Michael
Published: October 2022

Tropical peatlands store globally significant quantities of carbon and are ecologically and culturally important, but little is known about their vulnerability to oil and gas exploration and extraction. Here, we analyse the exposure of tropical peatlands to the activities of the petroleum industry and review what is known about the sensitivity of peatlands to these activities. We find that 8.3% (107,000 km2) of the total area of tropical peatlands overlaps with a 30-km buffer area around oil and gas infrastructure. Major areas of overlap include the Sumatra Basin (Indonesia), the Niger Delta (Nigeria) and the Putumayo-Oriente-Marañón Basin (Peru/Ecuador/Colombia). Documented environmental impacts include deforestation and habitat loss associated with the exploration and development of oil fields, and contamination from spills of oil and produced water (well brine). Peatlands, and the ecosystem services they provide, are sensitive to these impacts due to unique aspects of their ecology and hydrology, the easy spread of contamination by flowing water, the long-term storage of contaminants in peat, and the slow degradation of oil under anoxic, waterlogged conditions. Given the potential negative consequences for human health, resource security, biodiversity, and carbon storage, we propose a research agenda to provide an improved evidence base to support effective governance.
Polyandrous females but not monogamous females vary in reproductive ageing patterns in the bean bug Riptortus pedestris
Authors: Park Yi Hang , Shin Donggyun , Han Chang S.
Published: October 2022

Background

In general, reproductive performance exhibits nonlinear changes with age. Specifically, reproductive performance increases early in life, reaches a peak, and then declines later in life. Reproductive ageing patterns can also differ among individuals if they are influenced by individual-specific strategies of resource allocation between early-life reproduction and maintenance. In addition, the social environment, such as the number of available mates, can influence individual-specific resource allocation strategies and consequently alter the extent of individual differences in reproductive ageing patterns. That is, females that interact with more partners are expected to vary their copulation frequency, adopt a more flexible reproductive strategy and exhibit greater individual differences in reproductive ageing patterns.

Methods

In this study, we evaluated the effect of mating with multiple males on both group- and individual-level reproductive ageing patterns in females of the bean bug Riptortus pedestris by ensuring that females experienced monogamous (one female with one male) or polyandrous conditions (one female with two males).

Results

We found that group-level reproductive ageing patterns did not differ between monogamy-treatment and polyandry-treatment females. However, polyandry-treatment females exhibited among-individual variation in reproductive ageing patterns, while monogamy-treatment females did not.

Conclusion

Our findings provide the first empirical evidence regarding the influence of the social environment on individual variation in reproductive ageing patterns. We further suggest that the number of potential mates influences group- and individual-level reproductive ageing patterns, depending on which sex controls mating. We encourage future studies to consider interactions between species-specific mating systems and the social environment when evaluating group- and individual-level reproductive ageing patterns.
Efficacy and safety of anti-PD-1/PD-L1 therapy in the treatment of advanced colorectal cancer: a meta-analysis
Authors: Li Yuegang , Du Yuwei , Xue Chi , Wu Pei , Du Nan , Zhu Guolian , Xu Huimian , Zhu Zhi
Published: October 2022

Background

Immune checkpoint inhibitors have shown promise in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) advanced colorectal cancer (CRC) immunotherapy, and many clinical trials have been conducted.

Objective

To evaluate the efficacy and safety of PD-1/PD-L1 inhibitors in advanced CRC.

Method

PubMed, Web of Science, Embase, and The Cochrane Library were searched for relevant studies up to September 2021. A retrospective cross-sectional data analysis was performed and Stata 16 software was used for analyses.

Results

Sixteen studies including 1503 patients were analyzed. The objective response rate (ORR) of anti-PD-1/PD-L1 was 23% (95% CI 0.14, 0.31); the overall 1-year survival rate (OSR) was 57% (95% CI 0.42, 0.73). The ORR of MSI-H/dMMR advanced CRC was 37% (95% CI 0.25, 0.48) and that of microsatellite stable/mismatch repair proficient (MSS/pMMR) disease was 11% (95% CI 0.06, 0.16). The ORR was 42% in the BRAF mutant subgroup and 19% in the RAS mutant group. The ORR was 14% in the PD-L1 ( +) subgroup and 32% in the PD-L1(-) subgroup. The rate of adverse effects was 85% (95% CI 0.80, 0.91).

Conclusion

Anti-PD-1/PD-L1 therapy in MSI-H/dMMR advanced CRC was associated with improved survival. Anti PD-1/PD-L1 combined with antiangiogenic drugs, targeted agents, or chemotherapy might be effective in MSS mCRC. Immunotherapy was effective for the BRAF mutant and KRAS/NRAS(RAS) mutant CRC. Low expression of PD-L1 was a potential predictive marker for positive response and outcome. The high incidence of adverse events at 85% was worthy of further investigation. Further analysis with a higher number of high-quality studies is needed to verify the conclusions.
Qualitative and quantitative study of fetal posterior fossa during the first trimester in a Chinese population
Authors: Feng Li , Sun Lijuan , Wang Jingjing , Sun Congxin , Lu Lijuan , Zhang Zhikun , Hu Yu , Wu Qingqing
Published: October 2022

Background

To establish the normal reference ranges for parameters related to the fetal posterior fossa in the first trimester (11 ~ 13+6 weeks of gestation) and to analyze the relationship between them and crown-rump length (CRL) among the Chinese population.

Methods

Singleton pregnancies of 11 ~ 13+6 weeks (CRL:45 ~ 84 mm) with both parents from China were randomly selected from January 2021 to November 2021. The related parameters of the posterior fossa including cisterna magna (CM), intracranial translucency (IT), brain stem (BS), brain stem to the occipital bone (BSOB), and brain stem/brain stem to occipital bone (BS/BSOB) were evaluated and measured in nuchal translucency (NT) mid-sagittal section clearly by an experienced sonographer (operator 1). To assess the reproducibility of the measurements, we randomly selected 50 pregnant women. According to the blind method, operators 1 and 2 respectively screened and measured relevant parameters. In addition, operator 1 examined and measured relevant parameters again 2 h after the first.

Results

This study included 1663 fetuses. All fetuses can clearly show the three spaces of the fetal posterior fossa. The ICCs (95% CI) of intra-operator reproducibility of CM, IT, BS, BSOB, BS/BSOB were 0.981 (0.952 ~ 0.991, P < 0.001), 0.929 (0.866 ~ 0.961, P < 0.001), 0.970 (0.946 ~ 0.983, P < 0.001), 0.991 (0.974 ~ 0.996, P < 0.001), 0.939 (0.892 ~ 0.965, P < 0.001), respectively; The ICCs (95% CI) of inter-operator reproducibility 0.926 (0.860 ~ 0.960, P < 0.001), 0.810 (-0.083 ~ 0.940, P < 0.001), 0.820 (0.645 ~ 0.904, P < 0.001), 0.804 (0.656 ~ 0.888, P < 0.001), 0.772 (0.599 ~ 0.871, P < 0.001), respectively. There was a linear correlation between CRL and the parameters related to the posterior fossa (CM, IT, BS, BSOB, BS/BSOB). CM (mm) = -1.698 + 0.532 × CRL (cm) (r = 0.829, P < 0.001); IT (mm) = 0.701 + 0.179 × CRL (cm) (r = 0.548, P < 0.001); BS (mm) = 0.403 + 0.349 × CRL (cm) (r = 0.716, P < 0.001); BSOB (mm) = -0.277 + 0.719 × CRL (cm) (r = 0.829, P < 0.001); BS/BSOB = 0.747—0.021 × CRL (cm) (r = 0.196, P < 0.001).

Conclusions

Qualitative and quantitative assessment of the fetal posterior fossa structure was feasible in the first trimester. We constructed the normal reference ranges of CM, IT, BS, BSOB, and BS/BSOB. Furthermore, CM, IT, BS, and BSOB were positively correlated with CRL, but BS/BSOB was negatively correlated with CRL.
The U.S. COVID-19 County Policy Database: a novel resource to support pandemic-related research
Authors: Hamad Rita , Lyman Kristin A. , Lin Feng , Modrow Madelaine F. , Ozluk Pelin , Azar Kristen M. J. , Goodin Amie , Isasi Carmen R. , Kitzman Heather E. , Knight Sara J. , Marcus Gregory M. , McMahill-Walraven Cheryl N. , Meissner Paul , Nair Vinit , O’Brien Emily C. , Olgin Jeffrey E. , Peyser Noah D. , Sylwestrzak Gosia , Williams Natasha , Pletcher Mark J. , Carton Thomas
Published: October 2022

Background

It is increasingly recognized that policies have played a role in both alleviating and exacerbating the health and economic consequences of the COVID-19 pandemic. There has been limited systematic evaluation of variation in U.S. local COVID-19-related policies. This study introduces the U.S. COVID-19 County Policy (UCCP) Database, whose objective is to systematically gather, characterize, and assess variation in U.S. county-level COVID-19-related policies.

Methods

In January-March 2021, we collected an initial wave of cross-sectional data from government and media websites for 171 counties in 7 states on 22 county-level COVID-19-related policies within 3 policy domains that are likely to affect health: (1) containment/closure, (2) economic support, and (3) public health. We characterized the presence and comprehensiveness of policies using univariate analyses. We also examined the correlation of policies with one another using bivariate Spearman’s correlations. Finally, we examined geographical variation in policies across and within states.

Results

There was substantial variation in the presence and comprehensiveness of county policies during January-March 2021. For containment and closure policies, the percent of counties with no restrictions ranged from 0% (for public events) to more than half for public transportation (67.8%), hair salons (52.6%), and religious gatherings (52.0%). For economic policies, 76.6% of counties had housing support, while 64.9% had utility relief. For public health policies, most were comprehensive, with 70.8% of counties having coordinated public information campaigns, and 66.7% requiring masks outside the home at all times. Correlations between containment and closure policies tended to be positive and moderate (i.e., coefficients 0.4–0.59). There was variation within and across states in the number and comprehensiveness of policies.

Conclusions

This study introduces the UCCP Database, presenting granular data on local governments’ responses to the COVID-19 pandemic. We documented substantial variation within and across states on a wide range of policies at a single point in time. By making these data publicly available, this study supports future research that can leverage this database to examine how policies contributed to and continue to influence pandemic-related health and socioeconomic outcomes and disparities. The UCCP database is available online and will include additional time points for 2020–2021 and additional counties nationwide.
Exploring spatial distribution of social vulnerability and its relationship with the Coronavirus disease 2019: the Capital region of South Korea
Authors: Kim Donghyun
Published: October 2022

Background & objective

The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to cause death and socioeconomic problems worldwide. This study examined the spatial distribution of social vulnerability to COVID-19 and its relationship with the number of confirmed COVID-19 cases in 2020, focusing on the Capital region of South Korea.

Methods

A traditional social vulnerability index (SVI), healthy SVI, and the difference of each SVI were constructed in 2015 and 2019. The traditional SVI was constructed across five domains: age, socioeconomic disadvantage, housing, income, and environment. The healthy SVI domains were: prevention, health-related habits, chronic disease, healthcare infrastructure, and mortality. The spatial distribution of the traditional SVI, healthy SVI, and confirmed cases of COVID-19 was explored using ArcGIS 10.5. Pearson correlation was used to identify the relationship between confirmed COVID-19 cases and the two SVIs and their changes between 2015 and 2019. Four multiple linear regression models were used to identify the impact of the changes of the two SVIs on the confirmed COVID-19 cases for the three episodes and total period with control of population using STATA/MP 16.1.

Results

Confirmed COVID-19 cases were concentrated in a specific area of the Capital region. The traditional SVI was more vulnerable in the outer regions of the Capital region, and some central, western, and eastern areas reflected an increase in vulnerability. Healthy SVI was more vulnerable in the northern part of the Capital region, and increase in vulnerability showed in some central areas above Seoul. By multiple regression with the population controlled, the difference of the traditional SVI between 2015 and 2019 showed a positive relationship with the confirmed COVID-19 cases in all models at a significance level of 0.05, and the 2019 integrated SVI showed a negative relationship with confirmed COVID-19 cases in all models.

Conclusions

The results of this study showed that the confirmed COVID-19 cases are associated with increased traditional SVI vulnerability between 2015 and 2019 and have a high positive relationship with the spread of COVID-19. Policy efforts are needed to reduce confirmed COVID-19 cases among the vulnerable in regions with relatively increased traditional SVI.
Positive intervention effect of mobile health application based on mindfulness and social support theory on postpartum depression symptoms of puerperae
Authors: Liu Chao , Chen Hao , Zhou Fang , Long Qiqi , Wu Kan , Lo Liang-Ming , Hung Tai-Ho , Liu Chia-Yih , Chiou Wen-Ko
Published: October 2022

Objective

This study investigated the effects of mobile health application designed based on mindfulness and social support theory on parenting self-efficacy and postpartum depression symptoms of puerperae.

Methods

We recruited 130 puerperae from a hospital in China and randomized them to an App use group (n = 65) and a waiting control group (n = 65). The App group underwent an 8-week app use intervention while the control group underwent no intervention. We measured four main variables (mindfulness, perceived social support, maternal parental self-efficacy and postpartum depressive symptoms) before and after the App use intervention.

Results

In the App group, perceived social support, maternal parental self-efficacy were significantly higher and postpartum depressive symptoms was significantly lower. In the control group, there were no significant differences in any of the four variables between the pre-test and post-test.

Conclusions

Our findings indicated that the mobile health application may help to improve perceived social support, maternal self-efficacy and reduce postpartum depressive symptoms. The finding of the mobile health application's effect extends our understanding of integrative effects of mindfulness and perceived social support on reduction of postpartum depressive symptoms and suggests clinical potentials in the treatment of postpartum depressive symptoms.
Developing and validating a comprehensive measure of coordination in patient aligned care teams
Authors: Amspoker Amber B. , Lester Houston F. , Spitzmueller Christiane , Thomas Candice L. , Hysong Sylvia J.
Published: October 2022

Background/Objective

Despite numerous extant measures assessing context-specific elements of care coordination, we are unaware of any comprehensive, team-based instrument that measures the requisite mechanisms and conditions required to coordinate successfully. In this study we develop and validate the psychometric properties of the Coordination Practices Survey, a context-agnostic measure of coordination for primary care teams.

Methods

Coordination items were developed based on a systematic literature review; items from previously developed scales were adapted and new items were created as needed; all items were refined after subject matter expert review and feedback. We collected data from Primary Care teams drawn from 1200 Veterans Health Administration (VHA) medical centers and outpatient clinics nationwide. 1645 primary care team members from 512 patient aligned care teams in the Veterans Health Administration completed the survey from 2015 to 2016. Psychometric properties were assessed after data collection using Cronbach’s alpha, intraclass correlations and multilevel confirmatory factor analysis to assess the factor structure.

Results

Our findings confirmed the psychometric properties of two distinguishable subscales of coordination: (a) Accountability and (b) Common Understanding. The within- and between-team latent structure of each subscale exhibited adequate fit to the data, as well as appropriately high Cronbach’s alpha and intraclass correlations. There was insufficient variability in responses to the predictability subscale to properly assess its psychometric properties.

Conclusion

With context-specific validation, our subscales of accountability and common understanding may be used to assess coordination processes in other contexts for both research and operational applications.