bluuebunny/crossref_metadata_2025 huggingface dataset:
Unilateral perineal hernia surgery. Case report
Authors: Carvalho Viana D. , Nakaza P. S. , Rodrigues Silva A. C. , Alves de Brucker A. L. , Carnauba Vicente P. U. , Cirqueira dos Santos J. , Mesquita Grangeiro D.
Published: December 2022

Perineal hernia results from weakening and/or the inability of the pelvic diaphragm to support the rectal wall, promoting caudal displacement of abdominal or pelvic organs in the perineum. Unneutered male dogs aged between 7 and 10 years are the most affected, being rare in females. The main clinical signs are unilateral or bilateral swelling of the perineal region, associated or not with tenesmus, dysuria, urinary and/or fecal incontinence, anuria and pain during defecation. The diagnosis is based on clinical history, anamnesis, physical examination, and complementary tests such as radiography and ultrasound. Clinical treatment can be done in some cases, but surgical intervention is required to resolve the problem. The present work aims to report the case of a patient treated at the FullPet Veterinary Clinic in Guarulhos, São Paulo, Brazil, a 7-year-old male Yorkshire canine, unneutered, weighing 4.5 kg. The same was submitted to surgery by the tradi­tional method of suture with nylon thread and enteropexy. When there was recurrence, surgical reintervention was necessary to correct the hernia using a polypropylene mesh.
Isolation and characterization of major degradants in dihydroergotamine injection
Authors: Basappa Praveen , MS Uma Shankar , Dama Venugopala Rao
Published: December 2022

In this study, we report the systematic approach for characterization of two major degradant impurities, which are not listed in any compendia and were formed during the stability studies of Dihydroergotamine mesylate injection (DHE). An ion-pair UPLC chromatographic method was developed to quantify the related substances present in the DHE injection drug product. The same was used to monitor the impurity profiling during its stability. The two unknown impurities were observed at RRT about 0.08 (Impurity-1) and RRT about 0.80 (Impurity-5) and found to be significantly increasing on stability. Forced degradation studies revealed the nature of the impurity and conditions required for enriching them. A Mass compatible HPLC method was developed to quantify only these two impurities using 25% ammonia and formic acid in water. Their mass numbers were identified using LC MS/MS with triple quadruple mass spectrometer coupled with a HPLC. These two impurities were then isolated from enriched products using preparative HPLC. These impurities were then characterized using Mass and NMR analysis along with Q-TOF elemental analysis.
Ders Değerlendirme Ölçeği (DDÖ): Geçerlik ve Güvenirlik Çalışması
Authors: KOÇ Ahmet , BULUT İsmail
Published: December 2022

Kalite sürecinde yürütülen faaliyetlerin iyileştirilmeye açık yönlerinin tespit edilebilmesi için paydaş görüşlerine başvurulması kaçınılmazdır. Eğitim- öğretim faaliyetlerinin temel öznesi konumunda olan öğrenci görüşleri sürekli iyileştirmede en önemli veri kaynaklarından biridir. Eğitim programlarının temel taşı olan derslerin planlamadan çıktılarına kadar tüm süreçlerinde öğrenci görüşlerine başvurulması önerilmektedir. Literatür incelendiğinde derslerin niteliğinin değerlendirilmesine yönelik öğrenci görüşlerine başvurulduğu çalışmaların oldukça sınırlı sayıda olduğu görülmüştür. Planlamadan ölçme değerlendirme aşamasına kadar tüm süreçlerde etkili bir ders nasıl tasarlamalıdır, temel problemi üzerine kurgulanan bu çalışma bir ölçek geliştirmesi çalışmasıdır. Öğrenci görüşlerini dikkate alarak tasarlanan bir ders planının dersin niteliğini artıracağı düşüncesinden hareketle bu çalışmada eğitim öğretim faaliyetlerinin niteliğini artırmaya çalışan ve kalite ve akreditasyon sürecini yürüten kurumlar için geçerliği ve güvenirliği sağlanmış ve dersin tüm boyutlarını ölçen bir veri toplama aracı geliştirilmesi amaçlanmıştır. Nicel araştırma yöntemiyle gerçekleştirilen bu çalışma, tarama yolu ile durum tespiti yapmak amacıyla 2022 yılında Hitit Üniversitesindeki 636 öğrenci ile yürütülmüştür. Açımlayıcı faktör analizi neticesinde ölçeğin 24 maddeden oluşan dört faktörlü bir yapıda olduğu belirlenmiştir. Doğrulayıcı faktör analizi neticesinde uyum indekslerinin kabul edilebilir düzeyde olduğu saptanmıştır. Ölçeğin tümü için iç tutarlık (Cronbach’nın Alfa) katsayısı 0,94; faktörleri için ise sırasıyla 0,93, 0,91, 0,86 ve 0,93 olduğu tespit edilmiştir. Bu netice, ölçeği oluşturan maddeler arasında yüksek düzeyde bir iç tutarlılığının bulunduğunu ve ölçeğin aralarında güçlü ilişki olan maddelerden oluştuğunu göstermektedir. Korelasyon analizinde ölçekteki bütün faktörler arasında pozitif ve anlamlı bir ilişki olduğu belirlenmiştir. Tüm bu analizlerin sonucunda “Ders Değerlendirme Ölçeği (DDÖ)”nin yükseköğretim programlarında yürütülen bir dersin niteliğini belirlemeyi sağlayan geçerli ve güvenilir bir ölçme aracı olduğu söylenebilir.
Bir Eleştirinin Eleştirisi: İmsâk Vakti Tartışmaları
Authors: ERDOĞAN Tunahan , KARAGÖZOĞLU İsmail
Published: December 2022

Ülkemizde 1982 yılına kadar güneşin ufkun altında 19 derecede bulunduğu vakte temkîn süresi eklenerek ilan edilen imsâk vakti, Diyanet İşleri Başkanlığı’nın yeni uygulamasıyla 1983 yılından itibaren -18 derece olarak değiştirilmiş, temkîn uygulaması ise tamamen kaldırılmıştır. Kamuoyunda hararetli tartışmalara ve kafa karışıklığına yol açan değişiklik kararı, Başkanlığa birtakım eleştiriler ve ithamlar yöneltilmesine neden olmuştur. Eleştirilerin özellikle iki konu üzerinde yoğunlaştığı görülmektedir: Birincisi, orucun başlangıç vakti olan fecr-i sâdıkın tespiti için aydınlığın ilk belirdiği anın mı yoksa iyice yayıldığı anın mı esas alınacağı. İkincisi, fecr-i sâdıkın tespitinde güneşin yükseklik açısının -19 derece mi yoksa -18 derece mi olacağı. İddia sahiplerine göre her iki konuda da İslâm âlimleri birinci görüşü, Avrupalı Hristiyan astronomi bilginleri ikinci görüşü tercih etmektedirler. DİB ise değişiklik kararı ile İslâm âlimlerinin görüşünü bırakıp Hristiyanların görüşünü benimsemiştir. Bu makale orucun başlangıç vaktinde yapılan değişikliğe Prof. Dr. Ahmet Şimşirgil tarafından yöneltilen ve bazı takvim hazırlayıcıları tarafından da dile getirilen eleştirilerin tetkik, tahlil ve tenkidini konu edinmektedir. Çalışmanın amacı iddia sahipleri tarafından dile getirilen eleştirilerdeöne sürülen argümanların doğru olup olmadığını tespit etmektir. Başka bir ifadeyle bu çalışma imsâk vaktinde yapılan değişikliğe yöneltilen eleştirilerin eleştirisini ele almaktadır. Çalışmada tarafların DİB’in ilgili kararına yönelttiği eleştirilerin ve ileri sürdükleri delillerin temel fıkıh ve astronomi eserlerindeki bilgilerle örtüşüp örtüşmediği metin analizine dayalı olarak mukayeseli biçimde ele alınmaktadır. Ulaşılan sonuçlara göre her iki konuda da fıkıh ve astronomi âlimleri arasında görüş birliği bulunmamakta, eleştirilerde öne sürülen deliller ise iddiaları ispatlayıcı bir nitelik taşımamaktadır. Araştırma, toplumun büyük bir kesimini meşgul eden güncel imsâk tartışmalarına eleştirel katkı sunması ve tartışmaların bilimsel bir zemine oturtulması bakımından önem arz etmektedir.
Concepções de estudantes do Ensino Fundamental sobre o SARS-CoV-2
Authors: Da Silva Goulart Aline , Athaide Rocha Kellen Mariane , Colman Espíndola Lima Quelen , De Vargas Barbosa Nilda Berenice , Teixeira da Rocha João Batista , Folmer Vanderlei
Published: December 2022

Em decorrência da pandemia COVID-19, as atividades escolares presenciais foram substituídas pelo ensino remoto. Assim, acreditamos que muitos estudantes tiveram dificuldades em entender questões relacionadas ao vírus. Diante disso, o objetivo deste estudo foi conhecer as concepções dos estudantes sobre o vírus. Foi realizada uma investigação com estudantes do 7º ao 9º ano, onde os mesmos desenharam e escreveram sobre o que entendiam sobre o SARS-CoV-2. Os resultados mostram que os estudantes apresentam conhecimentos errôneos sobre vírus. Os alunos também representaram o coronavírus com características humanizadas e o associaram com bactérias. No entanto, os estudantes enfatizam em suas descrições que os vírus são invisíveis, mas não sabem ao correto o tamanho real do mesmo. Assim, ressalta-se a importância de abordagens mais aprofundadas acerca dessa temática, que facilitem a aprendizagem dos estudantes para que os mesmos sejam conhecedores e disseminadores de informações corretas.
Como calcular o equilíbrio de Hardy-weinberg para o ensino de polimorfismos genéticos? Uma planilha facilitadora para aula remota de biologia molecular
Authors: Ribeiro Junior Howard Lopes , Goes João Vitor Caetano
Published: December 2022

Este artigo descreve uma planilha de autopreenchimento completa para o cálculo de Hardy-Weinberg Equilibrium (HWE) para facilitar a compreensão da importância do cálculo de HWE para pesquisa experimental sobre análise de polimorfismo em uma classe remota de biologia molecular durante o período pandêmico do Coronavirus 2019 (COVID-19).
Functional status after PICU hospitalization – a six-month follow-up: a multicenter study
Authors: Oliveira Jéssica Knisspell de , Schaan Camila W. , Campos Camila M. de , Vieira Nathalia , Rodrigues Rayane S. , Moraes Larissa S. de , Lukrafka Janice L. , Ferrari Renata S.
Published: December 2022

BACKGROUND: After a critical disease many complications could appear, one of them is functional impairment. OBJECTIVES: To evaluate the functional status of critical pediatric patients after hospital discharge. MATERIALS AND METHODS: Prospective longitudinal observational study, included 214 patients with age between one month and <18 years old, who needed PICU admission. The functional status was evaluated with Functional Status Scale (FSS-Brazil) at baseline, PICU discharge, hospital discharge, three and six months after this and new morbidity was defined as a worsening in functional status in the FSS-Brazil of two or more points in the same domain compared with the baseline score. The Generalized Estimating Equation model was used to compare the FSS-Brazil scores. McNemar Chi-square test was used to evaluate the difference between the categories of functional status in each domain. Poisson regression was performed to determine associations between clinical variables and functional status. RESULTS: Of the 214 patients, 135 finished the follow-up. The majority of the sample was males (57.5%), with some chronic condition (76.2%) and 45.8% were readmitted to the hospital. It was observed moderate dysfunction in FSS-Brazil score (10-15) at PICU discharge (42.1%) and the new morbidity was observed in 11.5% of the sample after hospital discharge. More days in invasive mechanical ventilation increases 1.02 the risk of new morbidity. CONCLUSIONS: Patients who needed PICU recovered functional status after hospital discharge and remained stable in three and six months. The incidence of new morbidity was low and invasive mechanical ventilation was a risk factor for new morbidity.
Sichere und effiziente Produktion durch Agentensysteme
Authors: Heid Manuel , Pfeifer Michael , Richter Detlev , Harder Dimitri , Motsch William , Gafur Nigora , Gösling Henning , David Alexander , Thomas Oliver , Ruskowski Martin , Wagner Achim
Published: December 2022

Im Bereich der modularen und flexiblen Produktion stellen konventionelle Ansätze für die Maschinensicherheit (Safety) Hürden in der Produktivität und Wirtschaftlichkeit dar. In diesem Artikel wird ein Konzept mit Fokus einer digitalen Produktionsplanung und -durchführung für Betreiber diskreter Produktionen entwickelt, welches die Sicherheits-Problematik durch einen Smart-Safety-Ansatz beantwortet und zur Steigerung der Effizienz der Produktion beiträgt. Im entwickelten Konzept werden verschiedene Akteure durch Softwareagenten repräsentiert, die je nach  Anforderung auf wissensbasierte oder erlernte und freigegebene Nebenbedingungen zurückgreifen.
Three‐Generation Households in a Central and Eastern European Country: The Case of Hungary
Authors: Monostori Judit
Published: December 2022

Using data from censuses and a microcensus between 1980 and 2016, this study examines the trends in three‐generational living arrangements, along with the factors that determine the prevalence and characteristics of the phenomenon in Hungary. Apart from the period between 1990 and 2001, the proportion of three‐generation households declined in all periods among households with children. In the decade after 1990, the rate increased due to the post‐transition economic recession and the severe housing shortage. The factors predicting a higher risk of three‐generation households were fairly consistent across the period considered, and the direction of the effect remained stable. However, some of those factors became more relevant over time (e.g., the education level of parents and single parenthood) and some became less relevant (e.g., rural residence). Meanwhile, three‐generation living is increasingly linked to social disadvantage, which is also the leading cause of poverty. This living arrangement is strongly associated with a stage in life where young people start to have children. Using data from the Hungarian Generations and Gender Survey, we determine that three‐generation living affects a significant proportion of families with children at a particular, relatively brief stage in their lives.
Hirayama Disease: Review on Pathophysiology, Clinical Features, Diagnosis and Treatment
Authors: Gomathy Saranya B ,   Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, Agarwal Ayush ,   Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, Garg Ajay ,   Department of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India, Vishnu Venugopalan Y ,   Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
Published: December 2022

Hirayama disease is a relatively unusual cause of cervical myelopathy characterized by uni- or bilateral asymmetric weakness, fasciculations and atrophy of the distal upper limbs, mostly seen in young males. The insidious weakness progresses over 3–5 years, after which it stops. Hirayama disease results from the abnormal anterior shifting of the posterior cervical dura that occurs during cervical flexion, leading to cord impingement. Electrophysiologic studies reveal denervation of C7–T1 myotomes and absence of sensory involvement. Dynamic magnetic resonance imaging of the cervical spine is essential in confirming the diagnosis. Treatment is aimed at primarily avoiding neck flexion, which is achieved with the help of a cervical brace; however, progressive disease calls for surgical intervention. Although the disease is self-limiting, it causes many functional impairments in affected individuals. In this review, we describe the epidemiology, pathophysiology, clinical manifestations, imaging characteristics, electrophysiologic findings, differential diagnoses and updates in the treatment of Hirayama disease. This review also aims to improve the awareness of this disease among clinicians, enabling early suspicion, diagnosis and management.
Extraditing Persons from Italy to Vatican City: Chimera or Real Possibility?
Authors: Seatzu Francesco
Published: December 2022

In the course of the last year Italy was confronted with the unusual request from the Vatican City to extradite an Italian national to face charges of embezzlement and misappropriation of Holy See funds. The Holy See requested the extradition of Cecilia Marogna, a self described intelligence analyst and private spy from Sardinia, who worked for Cardinal Angelo Becciu, a senior Vatican official who was demoted over embezzlement claims. The case has received considerable press coverage and attention through print and online media worldwide, not least because of its numerous twists and turns such as the arrest of Marogna in Milan on an Interpol warrant issued at the Holy See’s request, the sudden drop of the extradition request by the Vatican authorities, and Italy’s highest court ruling thatCecilia Marogna never should have been arrested before a court evaluated whether she could be extradited. The aim of this Article is to explore whether the extradition of an Italian national, from Italy to the Vatican, unlike what has been claimed by Marogna’s defense lawyers and implicitly accepted by the Vatican authorities that dropped the extradition request, is instead possible. The thesis defends this possibility regardless of the absence of a bilateral extradition treaty between Italy and the Vatican and of an ad hoc extradition agreement between Italy and the Holy See. But this is only provided that the request for extradition concerns an Italian citizen convicted or accused of corruption-related crimes like Cecilia Marogna. This Article will proceed as follows: after an introduction,Section 1 will discuss and reject an argument that infers a prohibition of extradition from Italy to the Vatican from the wording of Article 22 of the Lateran Treaty of 1929. Sections 2 and 3 will consider and exclude that an obstacle to extradition from Vatican City to Italy may be inferred from the poor quality of the criminal justice system in Vatican City or from the authoritarian character of the Vatican’s internal legal order that is only presumed but not demonstrated. Finally, Section 4 will claim and argue that a proper duty toextradite persons not only from the Vatican to Italy but also from Italy to the Vatican should be inferred from Articles 43 to 49 of the United Nations Convention against Corruption (UNAC) of which both Italy and the Vatican City/Holy See are bound as contracting parties.
The Political Economy of Technology Transfer Rules of the US-China Phase One Trade Agreement: Competition of Global Technology Leadership
Authors: Tian George
Published: December 2022

Over the past four decades, Intellectual Property (IP) has been one of the main controversies of US-China trade relations. But the current US-China trade war contains a new focus – technology transfer. This article adopts a socio-legal and economic approach to examine the current technology and trade tensions between these two countries and why China became an Information Technology (IT) powerhouse. It first provides an overview of IP and technology transfer rules under the Phase One US-China Economic and Trade Agreement (POA). It then explores different forms of forced technology transfer activities and the in-depth reasons for the US to shift its main IP concerns from IP enforcement to technology transfer. It explains why the US and China trade war is inevitable, why the current US-China IP-trade war is significantly different from previous ones, and the economic and political reasons behind the global technology leadership competition by the two countries. Finally, the author concludes that the POA and its technology transfer rules are not the ends of the game but just the start of the global technology leadership competition between the US and China.
Innovative Foundation Alternative Inspired from Tree Roots
Authors: Larranaga Macie
Published: December 2022

It is not easy to find a more efficient foundation system than the roots of a tree. Trees create a vast three-dimensional network of roots to support and anchor the critical above-ground trunks, leaves, and limbs. In this work, investigations are made for the feasibility of imitating such a technique and creating similar networks to support civil infrastructure, particularly those subjected to moment loads such as traffic signal posts. Some of the raised questions were: Is it feasible to have a shallow tree root-based foundation system to provide the same capacities as conventional foundation alternatives? If this is feasible: What would be the ideal depth of the Root Foundation System? How far should the roots extend to provide comparable support to a conventional deep foundation system? What diameter should the root bulb of the configuration be? How far should a vertical shaft extend into the ground?

Hence, the main objective of this research is to identify and test the most effective Root Foundation System geometric configurations that can provide a similar capacity as a conventional foundation for traffic signal posts. Finite element model simulations on 54 different root-based foundation models show potential for replacing the conventional drilled shaft foundation for traffic signal posts. The conventional foundation was also modeled and produced a 0.528 mm deflection. Whereas some of the best performing root foundation models achieved 0.23 mm. By comparing the resulting deflection of the conventional foundation model to the deflection of the root foundation models, the best performing root foundation models were constructed from steel and physically tested. The root foundation models were then calibrated to predict the performance of root foundation models. Results show that the RFSs with half the length and diameter of conventional deep foundations (for traffic signal poles) were able to provide more than four times the lateral load capacity compared to the control sections. This shows that RFSs have excellent potential to replace the conventional deep foundation alternatives used to support traffic signal posts. The economic and environmental impacts due to the root-inspired foundation systems could be tremendous owing to the reductions in the material requirements.
Measuring Engineering Students' Engagement in Sustainability Design Concepts
Authors: Perez Karen Aide
Published: December 2022

Within industries, governments, and accreditation organizations, there has been a push to incorporate sustainability concepts into their models. Universities like Boise State University (BSU) have already begun to place greater emphasis in inclusion of sustainability concepts in different engineering department curricula. As part of this effort, BSU plans to redesign courses to integrate sustainability concepts using active learning modules (ALMs) suited for each grade level and discipline. The effectiveness of these modules will be evaluated across disciplines. In support of this larger goal, the work in this study will specifically focus on mechanical engineering students.

A survey instrument was developed for distribution to BSU mechanical engineering students and mechanical engineering alumni to investigate their knowledge and attitudes towards these topics but particularly in sustainable practices. In addition, interviews were conducted where alumni were able to discuss their values and learning retention with sustainable development. It is estimated that there will be approximately 200 participants across both the student and alumni survey. By applying a mixed methods approach to the survey instrument, students and Boise State Engineering alumni will have the opportunity to express their perception of BSU’s current integration of sustainability concepts. The responses will allow mechanical engineering courses to accurately and effectively present sustainable concepts. The results will be presented with demographics Likert-scaled bar graphs that includes the interpretation of the p-value, standard deviation and mean. This paper addresses the challenges and issues that academic and industry facilities face when bridging these engineering practices with these concepts.
Ranchers' and Federal Land Managers' Perceptions of Rangeland Management Across an Environmental Gradient
Authors: Puntenney Calandria
Published: December 2022

Managing semi-arid rangelands to meet social-ecological goals requires monitoring of key ecological indicators that will inform management responses. These goals and monitoring objectives are in turn grounded in land managers’ understandings, or “mental models,” of how the rangeland system operates. Rangeland managers’ mental models are often highly place-specific, which can enable management actions to be matched to local conditions. In the western United States, ranchers and federal agency resource specialists, like those in the Bureau of Land Management (BLM), are two of the primary groups involved in rangeland management. We compared ranchers’ and BLM agency specialists’ rangeland mental models in two regions of southern Idaho, along a climatic and elevational gradient. We conducted semi-structured interviews about their land management goals and objectives, as well as important rangeland system dynamics, from their perspectives. We used a mixed-methods approach, including network analysis metrics, to elucidate similarities and differences in their mental models, and in the ecological indicators that they use to assess rangeland health and to trigger management actions in service of their goals and objectives. We also investigated self-assessed constraints on ranchers’ and agency specialists’ ability to take the actions necessary to make progress towards their goals. We found that their overarching goals differed more between social groups than by geographic regions, whereas specific management objectives differed more by region. Ranchers’ and agency specialists’ mental models indicated divergent perspectives on the seasonal impacts of livestock on soils and vegetation and about the use of grazing to maintain processes in the ecosystem. There were also geographic differences in the mental models related to the reliability of plant growth and the prioritization of managing for invasive annual grasses and fire. Similarities between ranchers’ and agency specialists’ mental models included ways in which they viewed plant species diversity and abundance as indicators of rangeland health and the use of plant height as an indicator for management actions, such as moving livestock. These findings indicate that ranchers and agency specialists have place-specific knowledge, but that their mental models are often more similar to others in their social group than to those outside their social group in the same region. Differences in their conceptions of rangeland management suggest areas for increased communication between ranchers and agency specialists, as well as potential opportunities for collaboration where complementary perspectives could better enable both groups to reach their management goals.
Automated Detection of Sockpuppet Accounts in Wikipedia
Authors: Sakib Mostofa Najmus
Published: December 2022

Wikipedia is a free Internet-based encyclopedia that is built and maintained via the open-source collaboration of a community of volunteers. Wikipedia’s purpose is to benefit readers by acting as a widely accessible and free encyclopedia, a comprehensive written synopsis that contains information on all discovered branches of knowledge. The website has millions of pages that are maintained by thousands of volunteer editors. Unfortunately, given its open-editing format, Wikipedia is highly vulnerable to malicious activity, including vandalism, spam, undisclosed paid editing, etc.

Malicious users often use sockpuppet accounts to circumvent a block or a ban imposed by Wikipedia administrators on the person’s original account. A sockpuppet is an “online identity used for the purpose of deception.” Usually, several sockpuppet accounts are controlled by a unique individual (or entity) called a puppetmaster. Currently, suspected sockpuppet accounts are manually verified by Wikipedia administrators, which makes the process slow and inefficient.

The primary objective of this research is to develop an automated ML and neural-network-based system to recognize the patterns of sockpuppet accounts
as early as possible and recommend suspension. We address the problem as a binary classification task and propose a set of new features to capture
suspicious behavior that considers user activity and analyzes the contributed content. To comply with this work, we have focused on account-based and
content-based features. Our solution was bifurcated into developing a strategy to automatically detect and categorize suspicious edits made by the same
author from multiple accounts. We hypothesize that “you can hide behind the screen, but your personality can’t hide.” In addition to the above-mentioned method, we have also encountered the sequential nature of the work. Therefore, we have extended our analysis with a Long Short Term Memory (LSTM) model to track down the sequential pattern of users’ writing styles.

Throughout the research, we strive to automate the sockpuppet account detection system and develop tools to help the Wikipedia administration maintain the quality of articles. We tested our system on a dataset we built containing 17K accounts validated as sockpuppets. Experimental results show that our approach achieves an F1 score of 0.82 and outperforms other systems proposed in the literature. We plan to deliver our research to the Wikipedia authorities to integrate it into their existing system.
Toxicological Investigation, Identification, and Bioactivity Evaluation of Steroidal Alkaloids Derived from Veratrum parviflorum
Authors: Seale Jared Taylor
Published: December 2022

Plants of the Veratrum genus have been used throughout history for their emetic properties, rheumatism, and for the treatment of
high blood pressure. However, inadvertent consumption of these plants, which resemble wild ramps, induces life threatening side effects attributable
to an abundance of steroidal alkaloids. Several of the steroidal alkaloids from Veratrum spp. have been investigated for their
ability to antagonize the Hedgehog (Hh) signaling pathway, a key pathway for embryonic development and cell proliferation. Uncontrolled activation
of this pathway is linked to the development of various cancers, most notably basal cell carcinoma and acute myeloid leukemia. Additional
investigation of Veratrum spp. may lead to the identification of novel alkaloids with potential to serve as chemotherapeutics.
This project aimed to identify steroidal alkaloids in V. parviflorum, perform a toxicological investigation for the presence of
these alkaloids in the blood and breast milk of patients who ingested V. parviflorum, and evaluate the bioactivity of these alkaloids
for inhibiting the Hh signaling pathway. Four steroidal alkaloids were identified in the ethanolic extract of V. parviflorum: cyclopamine,
veratramine, jervine, and muldamine. Cyclopamine, veratramine, and jervine were identified in patient blood while cyclopamine and veratramine were
identified in patient breast milk. A bioactivity assessment of the V. parviflorum extract using Shh-Light cells suggested that there
are additional compounds within the plant that are antagonistic to the Hh signaling pathway.
Study as Form-of-Life
Authors: Weeks Bryan K.
Published: December 2022

The aim of this thesis is to explore what potential that the concept of 'inoperativity' has in the philosophy and theory of education. I will discuss the method of critique used which aims to think through the problems in existing theory rather than discard good thinking when problems are found. The strengths and weaknesses of deschooling and democratic approaches will be at the center of this critique. As a response to the weaknesses of both, the philosophy of Emmanuel Levinas, focusing on the way that interiority and enjoyment are essential concepts for the philosophy of education, as well as Giorgio Agamben, the philosopher of form-of-life, will be analyzed, demonstrating that we might find something vitally important in an inoperative understanding of concepts like study and and school.
Regression Analysis of Resilience and COVID-19 in Idaho Counties
Authors: Zaman Ishrat
Published: December 2022

Global pandemic Coronavirus Disease 2019 (COVID-19) has serious harmful effects on our day-to-day lives. To overcome challenges such as this, critical preparedness, readiness, and response actions are required. This thesis uses estimates of community resilience available through the CRE Tool, published by the US Census Bureau, and COVID19 cases published by John Hopkins Coronavirus Research Center for Idaho counties. Simple linear regression analysis was performed to identify a correlation between COVID-19 cases and deaths in Idaho counties and measures of their resilience. Understanding this correlation could lead to better estimation and prediction of the effect of disasters in Idaho’s counties.

We determined that there is a weak negative correlation exists between the number of COVID-19 cases and the percentage of people who fall into low-risk categories, a weak positive correlation between the number of cases and the percentage of people who fall into medium-risk categories. We also determined that there is a moderate positive correlation between the number of deaths and the percentage of people in a high-risk category. Analysis of the residuals requires further study.
I-optimal Designs for three and four component mixture models in orthogonal blocks
Authors: Hasan Taha , Hussain Syed Adil
Published: December 2022

In Industrial and Pharmaceutical experiments it is desired to have best predictions of the response on the basis of small amount of data.  Mixture experiment generally aims to predict the response(s) for all possible mixture blends. When we compute optimal design for mixture response surface we must focus on prediction capability of the design. The conventional optimal criteria, such as D-, A- and E-optimality are not suitable for determining the prediction capability of designs. As I-optimal design minimizes the average variance of prediction over the mixture region, so it clearly focuses on prediction capability of the design. Hence I-optimal criterion seems to be more appropriate in this conjecture.  In this paper we propose the construction of I-optimal mixture designs for a quadratic Scheffé’s and Darroch and Waller’s model in three and four components, using two orthogonal blocks.  I-efficiency of designs is compared with the I-efficiency of D-optimal designs for Scheffé’s and Darroch and Waller’s models.
The Topp-Leone Extended Exponential Distribution: Statistical properties, different estimation methods and applications to life time data
Authors: Aidi Khaoula , Seddik-Ameur Nacira , Ahmed Abdelbaset , Mundher A. Khaleel
Published: December 2022

Al-Shomrani et al. (2016) introduced a new family of distributions (TL-G) based on the Topp-Leone distribution (TL) by replacing the variable x by any cumulative distribution function G(t). With only one extra parameter which controls the skewness, this family is a good competitor to several generalized distributions used in statistical analysis. In this work, we consider the extended exponential as the baseline distribution G to obtain a new model called the Topp-Leone extended exponential distribution TL-EE. After studying mathematical and statistical properties of this model, we propose different estimation methods such as maximum likelihood estimation, method of ordinary and weighted least squares, method of percentile, method of maximum product of spacing, method of Cramer Von-Mises, modified least squares estimators and chi-square minimum method for estimating the unknown parameters. In addition to the classical criteria for model selection, we develop for this distribution a goodness-of-fit statistic test based on a modification of Pearson statistic. The performances of the methods used are demonstrated by an extensive simulation study. With applications to covid-19 data and waiting times for bank service, a comparison evaluation shows that the proposed model describes data better than several competing distributions.
Bayesian bivariate spatial shared component model: mapping breast and cervical cancer mortality in Southern Brazil
Authors: Martinez Edson Zangiacomi , Gafuri Silva Diego , Intrebartoli Resende Larissa , Aparecida da Silva Lizzi Elisangela , Achcar Jorge Alberto
Published: December 2022

Spatial analysis techniques are used in the data analysis of ecological studies, which consider geographical areas as observation units. In this article, we propose a Bayesian bivariate spatial shared component model to mapping the breast and cervical cancer mortality in Southern Brazil, based on the models introduced by Knorr-Held and Best (2001) and Held et al. (2005). Markov Chain Monte Carlo (MCMC) methods were used to spatially smooth the standardized mortality ratios (SMR) for both diseases. Local Indicator of Spatial Association (LISA) was used to verify the existence of spatial clusters in specific geographical areas. This study was carried out using secondary data obtained from publicly available health information systems.
Discrepancy of blood pressure between limbs bilateral subclavian artery stenosis: a case report
Authors: Ravichandran Arvindraj , Anand N. N. , Ramalingam A. Karthick , Mohan Anandh
Published: December 2022

Bilateral subclavian artery stenosis is a rare condition which usually presents with claudication pain associated with severe cardiac complications. Here we describe a rare case of asymptomatic bilateral subclavian artery stenosis. On examination, the patient was drowsy, dehydrated, and hypotensive, with evidence of DKA, for which the patient was treated, but the hypotension was persistent, with blood pressure in the lower limb more than that of the upper limb. A complete examination was done, and the USG neck and CT Aortogram showed retrograde flow in the left vertebral artery, increased flow velocity in the subclavian artery and filling defect in the bilateral subclavian artery, respectively. Thus, bilateral subclavian artery stenosis was diagnosed and treated accordingly.
An overview of pigmented lesions of the oral cavity
Authors: Alanazi Dalal Mufadhi , Alanazi Badria Moashi , Alanazi Hilalah Masoud , Al-Shahrani Ghada Khairallah , Alanazi Abeer Abdulhai , Alenazy Tamam Mohammed , Alruwaili Amirah Hamoud , Almutairi Reem Awwadh , Alanazi Suad Murdhi
Published: December 2022

It might be difficult to diagnose pigmented lesions of the mouth and perioral regions. Although several lesions may be correctly identified on the basis of clinical findings alone and while epidemiology may be helpful in guiding the clinician, the histological examination is typically necessary for the final diagnosis. Oral hyperpigmentation may present exogenously/ endogenously; pathologically/physiologically. The differential diagnosis depends on factors like medication usage, familial history in addition to the position, spread, and length as well as hue and pattern variations. Physiological pigmentation, melanotic macule, melanocytic nevus, smoker's melanosis, oral melanoacanthoma, pigmentation caused by foreign matter or medicines, Peutz-Jeghers syndrome, Addison's disease, and oral melanoma are examples of dark or black pigmented discolorations that can be unifocal, multifocal, or dispersed macular lesions.
Risk factors and screening benefits in pregestational and early gestation diabetes
Authors: Dahab Amaal Abdo , Aljohani Taghreed Mohamed , Heameed Roaa Ali , Alshehri Faisal Abdullah , Alrasheedi Maha Zaidan , Alsaegh Amna Ismaeel , Yahya Safa Metahr , Alanazi Deema Faleh , Alsomali Abdullah Jama , Zainaldeen Amani Mohammed Al , Slais Zainab Adel
Published: December 2022

Gestational diabetes is one of the most widespread complications of pregnancy posing a serious clinical and public health challenge. Globally, 16.5% of pregnancies are affected by the gestational diabetes, and this percentage is expected to rise as the obesity pandemic spreads. It has severe short-term and long-term negative health effects on both the mother and the child, which emphasizes the importance of identifying the risk factors for gestational diabetes and taking steps to prevent the illness. Gestational diabetes occurs when pregnant women who have never been diagnosed with diabetes experience chronic hyperglycaemia caused by impaired glucose tolerance. Obesity, physical inactivity, multiparity, family history of diabetes mellitus, certain ethnicities, birth of a previous macrocosmic child are all risk factors for gestational diabetes. Maternal cardiovascular disease, type 2 diabetes, macrosomia, and difficulties in delivery are all some of the complications of gestational diabetes. Additionally, there is a longer-term risk for the child to develop obesity, type 2 diabetes, and cardiovascular disease. Screening and diagnostic tests for gestational diabetes are essential to identify the women who are at risk for developing gestational diabetes and thereafter reduce or eliminate the risk of unfavourable outcomes for both mother and child associated with gestational diabetes. Oral glucose tolerance test is the widely accepted screening test conducted between 24-28 weeks of pregnancy for the diagnosis of gestational diabetes. The purpose of this research is to review the available information about risk factors and screening benefits in pregestational and early gestational diabetes.
Dioses útiles. Naciones y nacionalismos
Authors: Lima Salvador
Published: December 2022

José Álvarez Junco, Dioses útiles. Naciones y nacionalismos, Barcelona, Galaxia Gutenberg, 2016, 316 pp.  ISBN 978-84-17088-92-7
Cluster Initiatives and Economic Resilience: Evidence from a Technology Cluster in Argentina
Authors: Díaz de Astarloa Bernardo , Tacsir Ezequiel
Published: December 2022

In this paper, we study the role of a cluster initiative in fostering economic resilience among firms in a local technology cluster in Argentina. We focus on two aggregate shocks that hit the Argentine economy, including first wave of the COVID-19 pandemic. Our analysis is based on interviews with authorities and members of the cluster initiative, local firms, and policy makers, as well as on firm-level administrative tax records. We find that the cluster organization provides members with resources that could foster resilience, including access to specialized human capital, information on business opportunities, and assistance in applying for government support programs. However, while members of the cluster organization appear to be more resilient than non-members, even within the same regional cluster, after conditioning on firm characteristics we find little evidence of a positive association between belonging to the cluster organization and economic resilience. Members of the cluster organization are neither less likely to exit nor adapt by switching their main economic activity and did not show statistically significantly higher revenue growth than nonmembers. Member firms do appear to have been more able than non-members to keep up with tax obligations during the first wave of the COVID-19 pandemic.
Analysis of Regulatory Policy in the Context of Sustainable Development of Eastern European Countries
Authors: Safonov Yuriy , Abramova Alla , Kotelevets Dmytro , Lozychenko Oleksandr , Popov Oleksandr , Almazrouei Suhail Zayed Hamad Khamis
Published: December 2022

The purpose of the article is to study the peculiarities of the implementation of regulatory policy on the example of Eastern European countries in the context of sustainable development. The methodological basis of the study is a comprehensive approach to the improvement of the methodology for determining the system of integral indicators of the implementation of the regulatory policy of economic development through the statistical analysis of the determination of the indicators of international ratings of the business environment and the assessment of the determining integral indicators of the regulatory policy according to the criterion of sustainable development. Completing the calculations of the proposed stages of the study made it possible to rank the countries selected for analysis. The article examines the factors of sustainable development of countries that generate a set of indicators of the factor load of the system of economic, social, innovative and infrastructural components based on the results of the implementation of the regulatory policy of the studied countries. The system of directions and measures for increasing efficiency, as well as improving the regulatory policy, which are expedient to implement in order to create conditions for the sustainable development of research objects, are substantiated. Based on the results of the research, it was established that the defining directions of improving regulatory policy in the context of sustainable development of Eastern European countries at the current stage are: increasing competitiveness, increasing economic activity of economic entities, improving public administration and regulatory tools. The proposed measures are aimed at improving the effectiveness of regulatory policy implementation.
Effects of Noise Pollution on Residents Living in Birzebbuga and the Introduction of Effective Mitigation Measures
Authors: Falzon Joseph , Gonzi Rebecca Emily Dalli , Camilleri Mario , Grima Simon
Published: December 2022

There exists a direct influence of noise pollution on people's quality of life which can lead to several short and long-term health consequences. This paper presents the first phase of a mixed-method study conducted to understand the effects of noise pollution on residents living in Birzebbuga, Malta, followed by a second phase project completed in 2021. A questionnaire was completed by 477 inhabitants to obtain demographic information and data about noise pollution, its influence on residents' activities, and noise source discomfort. The study utilised the International Commission on the Biological Effects of Noise's five-scale technique to quantify noise irritation. The survey took place between February and May 2021. Data reported that in 98% of the participants noise pollution is a problem. 61.6% of respondents reported noise annoyance as the main category of pollution on health and well-being, followed by sleeping disorders and fatigue, stress, nervousness, loss of concentration, headaches and reduced ability to work. Given high levels of noise and the effects on the quality of life of residents, this study concludes that noise reduction regulations are a must, and a permanent sound monitoring network within the district of Birzebbuga is a crucial component for an effective low-noise implementation plan.
Analysis of Content Validity on Mathematical Computational Thinking Skill Test for Junior High School Student Using Aiken Method
Authors: Putri Yusriyyah Febriani , Kadir Kadir , Dimyati Ahmad
Published: December 2022

Computational thinking skills are a relevant approach to future problem-solving. Therefore, these skills need to be integrated into mathematics learning in schools. This research is part of developing mathematical computational thinking skill tests for junior high school students. In this segment, the study aims to analyze the content validity of the mathematical computational thinking skill test. The main stages in this research are define, design, and develop. Expert validation data were collected using Google Form sheets. The analysis technique used is the content validity technique with the V Aiken method.  The results of the study revealed that the results of content validation through the assessment of 7 experts, developed a test specification containing 20 items that measure mathematical computational thinking skills with a coefficient (V) in the interval (0.770 – 0.920) with an average of 0.866 or very good category. The test instrument is valid for measuring decomposition indicators, pattern recognition, abstraction, algorithmic thinking, and evaluation indicators. Each indicator is measured by 4 items with a coefficient of V decomposition indicator of 0.868, pattern recognition 0.883, abstraction 0.865, algorithmic thinking 0.833, and evaluation 0.883. The study concludes that the indicators of decomposition, pattern recognition, abstraction, algorithmic thinking, and evaluation indicators are valid in measuring mathematical computational thinking skills.