bluuebunny/crossref_metadata_2025 huggingface dataset:
Family functioning and insomnia in secondary vocational school students: the chain-mediated role of paranoia and anxiety
Authors: Wang Xinyue , Duan Xiang , Wu Taimin , Deng Weixi , Yang Bing Xiang , Luo Dan , Xie Yaofei , Liu Lianzhong
Published: November 2024

Objective
Investigate the current state of insomnia among secondary vocational school students, identify its influencing factors, and explore potential mechanisms of action.
Methods
The study population consisted of 2150 students (968 male, 1182 female) enrolled in a secondary vocational school in Wuhan, China. A cross-sectional research design was employed for the purpose of analyzing the data using descriptive statistics, correlation analysis, structural equation modeling, and bootstrap.
Results
Adolescents with poorer family functioning, higher levels of paranoid personality traits, and higher levels of anxiety are more likely to experience insomnia. There was a significant direct association between family functioning and insomnia (β = -0.153, p < 0.001). Paranoid personality traits and anxiety were not only significant independent mediators in the relationship between family functioning and insomnia (paranoid personality traits: β = 0.021, 95% CI: [-0.035, -0.008]; anxiety: β = 0.173, 95% CI: [-0.204,-0.114]), but also chain mediators (β = 0.059, 95% CI: [-0. 073,-0.048]).
Conclusion
Managing insomnia in secondary vocational school students requires familial and individual strategies, including reducing family conflict, improving family functioning, and addressing cognitive biases and anxiety.
Compound probiotic alleviates hyperuricemia-induced renal injury via restoring gut microbiota and metabolism
Authors: Liu Ping , Hu Ping , Jin Meiping , Sun Weiqian , Wu Jiajun , Tang Yuyan , Shi Danye , Ting Xie , Tong Yijing , Huang Lusheng , Zhang Dongliang , Zheng Hui , Xu Xudong , He Haidong
Published: November 2024

To investigate the role and mechanisms of intestinal microbiota in hyperuricemia-induced renal injury, renal failure models were established using unilateral nephrectomized mice. Following four weeks of a diet supplemented with adenine and potassium oxalate, a probiotic intervention was implemented. H&E staining and plasma biochemical assessments were employed to monitor renal pathological and functional alterations. Changes in intestinal microbiota and metabolites were analyzed through fecal microbial 16S rRNA gene sequencing and non-targeted metabolomics. The compound probiotic was found to alleviate renal functional impairment and interstitial fibrosis associated with hyperuricemia, while also reducing oxidative stress, mitophagy, and apoptosis in renal tubules. Furthermore, probiotics enhanced the diversity of the intestinal flora, significantly increasing the abundance of Prevotella_9, Dorea, and unclassified Bacteroidota, while decreasing the abundance of unclassified Desulfovibrio. KEGG enrichment analysis indicated that probiotic intervention upregulates arginine and proline metabolism, as well as tyrosine metabolism in feces. Additionally, it enhances the metabolism of arginine, proline, valine, leucine, and isoleucine in plasma. Sulfocholic acid and urocanic acid were negatively correlated with indicators of oxidative stress, autophagy, and apoptosis, while L-proline in plasma also exhibited a negative correlation with these parameters. The compound probiotic may ameliorate kidney damage resulting from hyperuricemia by restoring the imbalance of intestinal flora and mitigating metabolite loss in plasma and feces. The underlying mechanisms may involve the reduction of oxidative stress and mitochondrial dysregulation associated with hyperuricemia, as well as phagocytosis-induced apoptosis. These findings suggest that probiotic supplementation could serve as a promising intervention for renal injury induced by hyperuricemia.
Novel ACSL5 Gene Mutation Causing Failure to Thrive: A Case Report
Authors: Vafadar Mehdi , Saeedi Vahid , Zarei Elham , Kamalzadeh Leila
Published: November 2024

Failure to thrive (FTT) in pediatrics is often attributed to various factors, including genetic anomalies. Acyl-CoA synthetase long-chain 5 (ACSL5), a critical player in fatty acid metabolism, has emerged as a candidate in monogenic causes of FTT. This case report presents a female infant with severe FTT, whose clinical course was marked by abnormal growth, gastrointestinal symptoms, and metabolic disturbances. Whole Exome Sequencing identified a novel homozygous missense mutation (Chr10-114182186 G>A; c.G1748A: p.G583D) in the ACSL5 gene, linking her condition to impaired fatty acid activation and palmitoylation. The patient's response to a low-fat formula containing medium-chain triglycerides (MCTs) showcased the potential of targeted therapy. Our study adds to the limited knowledge of ACSL5 deficiency, highlighting the clinical significance of genetic testing and the role of fatty acid metabolism in pediatric health.
Self-compassion, body appreciation, and eating disorder symptoms: A diary study
Authors: Batchelor Rachel , O'Leary Bree , Egan Sarah J , Thøgersen-Ntoumani Cecilie
Published: November 2024

Purpose
Body image concerns and disordered eating are common among young adults. Previous research has shown that self-compassion is associated with less disordered eating and greater body appreciation. However, the majority of this research has examined between-person associations. The aim of this study was to examine dynamic within-person associations between self-compassion, body appreciation, and disordered eating in young adults.
Methods
Fifty-seven participants (40 females, 17 males) (mean = 25.28, standard deviation = 3.09, age range 18–30 years) aiming to lose weight reported their levels of self-compassion, body appreciation, and disordered eating twice daily over a one-week period.
Results
The findings showed that when participants were more self-compassionate, they expressed more body appreciation and engaged in less disordered eating. Further, when participants reported higher levels of body appreciation, they reported engaging in less disordered eating.
Conclusion
The findings suggest that further research should examine whether fostering self-compassion and body appreciation may be putative targets to reduce disordered eating in young adults who aim to lose weight.
Level of evidence
Level III Evidence obtained from welldesigned cohort or case control analytic studies.
Surveillance and Characterization of Carbapenem-resistant Enterobacter cloacae Complex from China, 2015-2018
Authors: Ye Kun , Zhang Yongqing , Qiu Xuemei , Ye Liyan , Ma Yanning , Yang Jiyong
Published: November 2024

Background: The carbapenem-resistant Enterobacter cloacae (CREC) has become a global health concern. However, our understanding of its epidemiological trends and resistance mechanisms still needs to be improved.
Methods: 92 non-repetitive clinical CREC isolates were collected from 12 hospitals across China and identified using MALDI-TOF MS, rMLST, ANI, MASH, and dDDH. Minimal inhibitory concentrations were determined via broth microdilution. Resistance genes and plasmid replicons were identified using ResFinder and PlasmidFinder. Carbonyl cyanide 3-chlorophenylhydrazone suppression test and OmpC and OmpF overexpression test were conducted on 32 non-carbapenemase-producing (NCP) isolates. A phylogenetic tree was constructed with kSNP4 and visualized through iTOL.
Results: Among the 92 CREC isolates, E. hormaechei was predominate (76 isolates), followed by E. kobei (five isolates). Within E. hormaechei, E. hormaechei subsp xiangfangensis was the most widespread subspecies. Sixty isolates produced carbapenemase, with blaNDM-1 identified in 36 isolates, blaKPC-2 in six isolates, and blaNDM-5 in six isolates. Two isolates harbored both blaNDM-1 and blaKPC-2. Thirty-two isolates were NCP isolates, primarily due to carbonyl cyanide 3-chlorophenylhydrazone suppression.
Conclusions: Among CREC in China, the blaNDM-1 was the dominant carbapenemase-coding gene. For NCP isolates, efflux pumps was the main reason for carbapenem resistance, and susceptibility could be restored in an antibiotic-free environment.
Rumen fermentation profile and anti-methanogenic properties of Mango and Avocado byproducts as feed ingredients and supplements
Authors: Jalal Hassan , Sucu Ekin , Cavallini Damiano , Giammarco Melania , Akram Muhammad Zeeshan , Karkar Büşra , Gao Min , Pompei Luigi , López Jorge Eduardo Angulo , Prasinou Paraskevi , Fusaro Isa
Published: November 2024

Fruit byproducts represent a sustainable alternative to conventional feed for ruminants, addressing food-feed competition and environmental concerns. Two experiments were performed to investigate the use of mango and avocado byproducts as feed ingredients and supplements, focusing on chemical composition, in vitro digestibility, and rumen fermentation characteristics. Experiment 1 assessed these parameters for mango peel (MP), mango seed kernel (MSK), mango seed coat (MSC), avocado peel (AP), and avocado seed (AS). Experiment 2 evaluated rumen fermentation parameters using a control (200 mg alfalfa hay) and four treatments, each with 200 mg alfalfa hay supplemented with 15 mg beta-cyclodextrin microencapsulated extracts: MPE (mango peel microencapsulated extract), APE (avocado peel microencapsulated extract), MSKE (mango seed kernel microencapsulated extract), or ASE (avocado seed microencapsulated extract). MSK had the highest crude protein content, whereas AP had the highest ether content. MSC and AP presented the highest fiber fractions. AP and MP showed higher total phenolic content and antioxidant capacity. In experiment 1, MSK, AS and MP resulted in greater invitro dry matter digestibility, metabolizable energy, and cumulative gas production compared to MSC and AP. AS, MSC, and MSK presented higher acetate to propionate ratios than MP and AP did. MSK resulted in the highest methane concentration, while AP and MSC produced the lowest. Ammonia nitrogen was highest in AP and lowest in MSC. In experiment 2, MSKE, ASE and the control had the highest cumulative gas production, followed by APE and MPE. Compared with the other treatments, APE reduced both the acetate-to-propionate ratio and methane production. Compared with the control, all the encapsulated extracts lowered the ammonia nitrogen concentration. Overall, MP, MSK, and AS have emerged as the most promising ingredients because of their relatively high digestibility, metabolizable energy, and fermentation efficiency, whereas APE and MPE have potential as feed supplements for reducing methane production.
Exploring the Impact of Cash-Based Interventions on Alleviating Food Insecurity Among Displaced Populations Amidst COVID-19: A Case Study of Cox Bazar, Bangladesh.
Authors: Achore Meshack , Abu Thelma , Mbaya Pindar Yawulda , Yeboah Eugene Osei
Published: November 2024

Food insecurity is a significant issue impacting millions of people compelled to abandon their homes due to conflict, natural disasters, or economic difficulties. Cash incentives have become a critical mitigating tool in alleviating the food insecurity challenges of these displaced populations amid COVID-19. This paper examines the determinants of food insecurity and how cash incentives alleviate food insecurity among displaced populations. The study used the 2020–2021 high-frequency survey data to achieve this objective. The high-frequency survey continues the 2019 Cox Bazar Panel Survey baseline, representative research of Rohingya displaced after 2017 in host communities in Bangladesh's Cox's Bazar district. Receiving cash transfers (incentives) is significantly associated with lower odds of experiencing food insecurity (OR = 0.19, CI = 0.91-0.380). Female participants have higher odds (OR = 3.44, CI = 1.41-5.36) of experiencing food insecurity than their male counterparts. Being a recipient of assistance from UN agencies was associated with slightly lower odds (OR = 0.88, CI = 0.69-0.97) of experiencing food insecurity. To achieve sustainable food security, we must integrate cash incentives into a comprehensive social support system that includes employment initiatives, affordable housing, healthcare, and education. This holistic strategy can address the underlying reasons why people face food insecurity, giving them the tools and chances to become stable in the long term and less reliant on short-term monetary incentives.
A Colloidal Nanofoundry for Catalytically Active Solid-Liquid-Solid Nanoparticles
Authors: Boulanger Coline , Esteban Daniel Arenas , Kumar Krishna , Leemans Jari , Albertini Petru , You Haoxuan , Assendjee Eachann , Stoian Dragos , Bals Sara , Buonsanti Raffaella
Published: November 2024

Nanoreactors represent a unique strategy to synthesize nanoclusters and nanoparticles with a diverse chemical nature and with a level of tunability that is difficult to achieve with conventional methods. Liquid metals (LMs) have emerged as an intriguing medium for materials synthesis, which hints at opportunities to their use as nanoreactors. Yet, their underdeveloped chemistry at the nanoscale has so far hindered the full exploitation of this research direction. Herein, we advance the chemical knowledge on the synthesis of LM nanoparticles (NPs) and demonstrate their use as a novel type of nanoreactor to access well-defined multi-metallic NPs. We propose a novel approach for the synthesis of colloidal solid-liquid-solid core-shell-shell NPs wherein a solid metal core (i.e. Ag, Au, Cu, Pd) is embedded into a liquid Ga NP surrounded by its native oxide skin. Using state of the art characterization tools, including in-situ electron microscopy and X-Ray absorption spectroscopy, we learn that a dissolution and recrystallization of the solid core within the liquid Ga NP occurs during the synthesis. We leverage this understanding to access unprecedented multi-metallic NPs, exemplified by Ag-Au nanodimers, within the liquid Ga shell. Finally, we demonstrate how the synergistic interactions between the solid metal core, the liquid Ga domain and the oxide skin are promising to explore these materials as a new class of electrocatalysts. The findings of this work deepen our understanding of LM NPs and advance the ability to design these unique nanomaterials with tailored properties for various applications using a novel nanoreactor strategy.
Structural Optimization Applied to Submarine Pressure Hulls
Authors: Shinoka Thiago Kenji Leao , Netto Theodoro Antoun
Published: November 2024

Submarine pressure hulls are designed in such a way that the total buoyancy is balanced by the total weight to maintain a specific desired water depth. Structural efficiency is, therefore, translated directly into a better payload and deeper operational range. This paper presents a study of the effectiveness of three optimization tools for the problem of minimizing the weight of pressure hulls: Differential Evolution (DE), Particle Swarm (PS) and Simulated Annealing (SA). Their convergence rate and final resulting structure were compared using an analytical model. The influence of the primary dimensions, design pressure and variations in the partial safety factors are also factored into the evaluation of the optimization tools. Once optimal structures according to different partial safety factors are attained, these are verified with Finite Elements Analysis (FEA) models considering an initial imperfection and with hydrostatic external pressure applied using the path-following Riks method. The results of this study indicate that the DE is the most effective method for the proposed problem among the tools evaluated and that the implementation of optimization tools in early design stages could potentially reduce the weight and improve the payload of submarines.
Development of 3D-structured tilt capillary valve for lab-on-a-disc devices
Authors: Murano Yuito , Yamamoto Shoji , Matsuzawa Hayato , Morioka Kazuhiro , Hemmi Akihide , Nakajima Hizuru
Published: November 2024

Lab-on-a-disc (LoD) devices utilize centrifugal force to regulate fluid movement and are widely employed in biochemical applications. LoDs facilitate biochemical analysis by integrating different essential steps such as mixing samples and reagents, separating target components from the sample, and detecting analytes in a single platform. This integration on a single disc substrate enables the miniaturization and automation of various biochemical workflows. However, current LoD systems frequently rely on active valves, which increase complexity and limit versatility. To address these challenges, this study employed 3D printing technology to develop a 3D-structured tilt capillary valve acting as a passive control mechanism. Tilt capillary valves with inclination angles ranging from 50° to 80° were fabricated, and their burst rotational speeds and repeatability were compared with those of conventional capillary and slope valves. The tilt capillary valve demonstrated superior performance, achieving high-speed fluid control with relative standard deviations ranging from 1.5% to 2.1%. This improvement was attained by distributing the effects of centrifugal and gravitational forces along the inclined flow path. Additionally, the capillary structure stabilized the effects of surface tension, further enhancing reproducibility. These findings suggest that the developed tilt capillary valve enhances the LoD system performance, enabling more precise and rapid fluid control. The enhanced passive valve presented in this study can be incorporated in advanced microfluidic device designs, opening new possibilities for biochemical assays, particularly in resource-limited environments.
b-move: Faster Lossless Approximate Pattern Matching in a Run-Length Compressed Index
Authors: Depuydt Lore , Renders Luca , de Vyver Simon Van , Veys Lennart , Gagie Travis , Fostier Jan
Published: November 2024

Background: Due to the increasing availability of high-quality genome sequences, pan-genomes are gradually replacing single consensus reference genomes in many bioinformatics pipelines to better capture genetic diversity. Traditional bioinformatics tools using the FM-index face memory limitations with such large genome collections. Recent advancements in run-length compressed indices like Gagie et al.'s r-index and Nishimoto and Tabei's move structure, alleviate memory constraints but focus primarily on backward search for MEM-finding. Arakawa et al.'s br-index initiates complete approximate pattern matching using bidirectional search in run-length compressed space, but with significant computational overhead due to complex memory access patterns.
Results: We introduce b-move, a novel bidirectional extension of the move structure, enabling fast, cache-efficient, lossless approximate pattern matching in run-length compressed space. It achieves bidirectional character extensions up to 7 times faster than the br-index, closing the performance gap with FM-index-based alternatives. For locating occurrences, b-move performs φ and φ inverse operations up to 7 times faster than the br-index. At the same time, it maintains the favorable memory characteristics of the br-index, for example, all available complete E. coli genomes on NCBI's RefSeq collection can be compiled into a b-move index that fits into the RAM of a typical laptop.
Conclusions: b-move proves practical and scalable for pan-genome indexing and querying. We provide a C++ implementation of b-move, supporting efficient lossless approximate pattern matching including locate functionality, available at https://github.com/biointec/b-move under the AGPL-3.0 license.
Prevalence and Determinants of Still birth in Mothers Delivered by Cesarean Section in Orotta National Referral Maternity Hospital: A Cross Sectional Study
Authors: Gebremariam Hailemichael , Tesfai Berhe , Frezgi Okbu , Hussein Khalid , Asrat Kibreab , Kibreab Fitsum
Published: November 2024

Background: Stillbirth is a growing public health issues worldwide and accounts for majority of perinatal death. In resources limited countries, 40% of stillbirth occurs during labor and this loss could be avoided with improved monitoring and timely access to emergency obstetric care when required. The aim of this study was to determine the prevalence of stillbirth and identify its determinants among mothers delivered by cesarean section.
Methods: It was a hospital based retrospective unmatched case control study. Mothers who delivered by cesarean section with the outcome of still birth were cases and three consecutive cesarean section deliveries with live birth were controls. Data were collected using structured data extraction tool developed from literature related to stillbirth and modified according to the local context by the investigators. Variables with p<0.05 in the univariable logistic regression were entered to multivariable logistic regression and declared significant at p<0.05.
Results: A total of 380 sampled chart of mother’s delivered by cesarean section were included in study. Of those, 95 were stillbirth and 285 were live birth. The prevalence of still birth on cesarean section deliveries was 3.3% and 48% of stillbirth and 54% of live birth were in mother’s aged 25 to 34 years. Emergency cesarean section was performed in 93% of stillbirth and 71% of live birth. The major indications for cesarean section were antepartum hemorrhage (37%) for stillbirth and mal-presentation (21%) for live birth. Besides, 70% of stillbirth and 73% of live birth have birth weight of 2500-4000gram. The result showed that emergency cesarean section (AOR: 0.32; 95%CI: 0.14-0.75) and male newborn (AOR: 3.03; 95%CI: 1.78-5.19) were found to have a significant association with stillbirth.
Conclusion: Our study indicates emergency cesarean section for antepartum hemorrhage was associated with increased stillbirth rate. Focusing on causes of antepartum hemorrhage during antenatal care, appropriate intrapartum monitoring and early risk assessment for complications is paramount for early intervention and prevention of still birth.
A Novel Hybrid Particle Swarm Optimization-Simulated Annealing Algorithm for Maximizing Coverage in IoT-Enabled Wireless Sensor Networks
Authors: Benelhouri Abdelkader , IDRISSI-SABA Hafida , Antari Jilali
Published: November 2024

This paper presents a novel hybrid Particle Swarm Optimization-Simulated Annealing (PSO-SA)algorithm for optimizing coverage in IoT-enabled Wireless Sensor Networks (WSNs). We addressthe critical challenge of maximizing network coverage while considering computationalcomplexity. Our approach combines the global search capabilities of PSO with the local optimizationstrengths of SA to achieve superior performance across various network scales. Weconducted extensive simulations for networks ranging from 10 to 50 nodes. The proposed algorithmsignificantly improved network coverage, with improvements of up to 27.8% for smallernetworks (N=10) and 9.16% for larger networks (N=50). The optimized configurations consistentlyachieved coverage ratios above 95% for networks up to 20 nodes, and maintained coverageabove 75% for larger networks of 30-50 nodes. The algorithm demonstrated rapid convergence,typically achieving near-optimal solutions within 200-300 iterations. However, we observed anexponential increase in execution time as network size grew, from approximately 200ms for 10nodes to over 6000ms for 50 nodes. This highlights the trade-off between optimization qualityand computational cost for larger networks. Our results also show that the hybrid PSO-SAapproach maintains higher solution diversity for larger networks, allowing for more thoroughexploration of the solution space. The algorithm achieved a balance between coverage improvementand computational efficiency, with the number of function evaluations remaining relativelyconstant (around 1.8 ∗ 10^5) across all network sizes.
Rumen Metagenomic Sequencing Profiling Reveals the Differential Regulation of Microbial Related to Key Mutton Flavor 4-Alkyl-Branched-Chain Fatty Acids in the Longissimus Dorsi Muscle of Lamb Feeding Allium mongolicum Regel
Authors: Wang XiaoYuan , Bai Chen , Erdene Khas , Cao QiNa , Zheng YanKai , Han GuoLi , Ao ChangJin
Published: November 2024

Background Three key branched-chain fatty acids (4-methyloctanoic acid, 4-ethyloctanoic acid, 4-methylnonanoic acid) (KBCFAs) have been identified as the primary contributors to the formation of mutton odor. Given the potential of Allium mongolicum regel in regulating mutton flavor (MF) and the regulation of rumen microbiota, it is hypothesized that Allium mongolicum regel may alter the structure of the gastrointestinal microbiota, subsequently affecting pathways related to odor synthesis, thus improving the flavor of lamb meat.
Methods A total of twenty lambs (Small-tailed Han sheep × Dorper sheep) were randomly selected and divided into two experimtetal groups. (1) basal diet as control group (CON); (2) basal diet supplement with 15 g/lamb/day Allium mongolicum regel powder as treatment group (AMR). The experimental period lasted for a total of 75 days. The effects of dietary AMR supplementation on lamb rumen fermentation, the three branched-chain fatty acids in the longissimus dorsi (LD) muscle, and rumen microbiota were evaluated.
Reasults. A comparison of the two groups revealed that the AMR group exhibited a notable reduction in the concentration of propionate and total volatile fatty acids (P < 0.05), while the AMR group demonstrated a significant decline in the concentration of KBCFAs in the LD muscle (P < 0.05). The relative abundance of Prevotellaat the genus level was found to be significantly reduced in the AMR group (P< 0.05), as was the relative abundance of Prevotella sp. Rep29 at the species level is significantly reduced in the AMR group (P < 0.05). The GH94 showed the positive correlation with MOA (R = 0.88, P < 0.05), while GT2 showed a negative correlation with EOA (R = -0.92, P = 0.03 ). The influential heatmap revealed that MNA demonstrated significantly negative correlations with Eubacterium callanderi, Intestinibaculum porci, Collinsella aerofaciens, and Serratia marcescens (P < 0.05). MOA showed significantly positive correlations with Prevotella sp. Rep29, and Chamaesiphon minutus, and showed significantly negative correlations with Eubacterium callanderi (P < 0.05). EOA were positively correlated with Prevotella sp. Rep29 and Pyramidobacter piscolens (P < 0.05). The co-occurrence networks indicate that bacterial stability in the rumen surpasses that of archaea, which in turn exceeds that of fungi. The KEGG pathways K01579, K17723, and K18933 are significantly upregulated in the AMR group in the pantothenate and CoA biosynthesis pathway (P < 0.05).
Balancing Performance and Cost in EC2 Instance Selection for Energy-Efficient Cloud Computing
Authors: Mishra Abheelash , B Ida Seraphim
Published: November 2024

This paper introduces a dynamic decision-making framework designed to optimize cloud resource allocation through the selection of the most suitable Amazon EC2 instance types based on specific workload demands. The system categorizes workloads into general-purpose, memory-intensive, and compute-intensive types, allowing user input to be translated into detailed technical requirements, such as the necessary virtual CPUs, RAM, expected usage duration, and performance needs. Leveraging a cost-performance scoring algorithm, the system filters and evaluates various EC2 instances to recommend optimal configurations that balance computational performance with budgetary constraints. This method not only maximizes cost-effectiveness but also reduces unnecessary resource utilization, minimizing operational inefficiencies and environmental impact associated with cloud over-provisioning. The proposed framework is particularly relevant in the context of scalable, energy-efficient cloud computing environments, as it aligns infrastructure usage with specific application requirements, thereby supporting more sustainable cloud operations. By helping users effectively match their cloud investment to workload necessities, this system offers a valuable solution for organizations looking to achieve both economic and ecological benefits in their cloud deployments.
Design and research of business processor of electricity consumption information collection system
Authors: CHENG Xingliang , Mingli ZHOU , LI Xiaojun , Tongyang ZOU , Siyu MEN , Lin CHEN
Published: November 2024

In order to improve the electricity consumption information collection system, this research designed a new type of business processor, which can realize the information collection of the user's electricity collection environment, and realize the collection of different information on the surrounding environment to detect the data information of the surrounding environment. Through the marketing and utilization of smart IoT, it realizes the operation of electricity data collection, parameter issuance, electricity statistics and line loss calculation for residential users, special transformer users, and substation gateways, which improves the intelligence and automation capabilities of electricity information collection. When designing the front-end processor, the power consumption information collection function is improved by establishing a connection with the front-end processor. The research also designed an active queue management (Active Queue Management, AQM) algorithm model, which can improve the power consumption information data transmission and application capabilities. Through experiments, the method of this research has greatly improved the business capability of the electricity consumption information collection system with high accuracy.
Stacking multi-timescale graph attention network and bidirectional gated recurrent units for traffic flow prediction
Authors: Liu Yizhi , Zou Zhengbiao , Tang Jingxin , Liao Zhuhua , Liu Yuxuan , Fang Zhixiong
Published: November 2024

Accurately predicting traffic flow becomes more and more important to intelligent transportation systems in the age of autonomous driving. Some existing methods extract spatial and temporal features of road networks respectively via graph convolutional network and recurrent neural network for traffic flow prediction. However, there are still threefold challenge of spatiotemporal coupling interrelations, dynamic spatial correlations, and the impact of periodic patterns and external factors. Addressing at these challenges, this paper proposes a novel approach of stacking multi-timescale graph attention network (GAT) and bidirectional gated recurrent units (BiGRU) for traffic flow prediction, called SMGAT-BiGRU. Firstly, a GAT feature extraction module is explored to capture the dynamic spatial correlation of different road segments, and then a multi-timescale feature fusion module is constructed to mine hidden periodic patterns and to capture the impact of external factors by extracting fine-grained spa-tiotemporal features and external dynamic time-varying features. Secondly, a BiGRU module with attention is proposed to capture temporal dependencies from dynamic spatial dependency sequences. Furthermore, a GAT-BiGRU module is presented to be stacked to fully capture the spatiotemporal coupling interrelations. Experimental results on two PeMS datasets show that SMGAT-BiGRU 1 can remarkably improve the performance of traffic flow prediction and outper-forms many state-of-the-art methods (such as T-GCN, STGCN, STSGCN, and DMSTGCN).
The effect of psychological capital on athlete burnout: the mediating role of coping strategies and the moderating effect of perceived stress
Authors: YU Xiaomei , XING Suxuan , YANG Yang
Published: November 2024

Athlete burnout represents a critical concern in sports psychology, significantly affecting athletes' well-being and performance. This study investigated the relationships among psychological capital, coping strategies, perceived stress, and athlete burnout. A cross-sectional survey was conducted among 344 athletes, and data were analyzed using SPSS Statistics 25.0 and PROCESS Macro v4.1 for hierarchical stepwise regression and moderated mediation analysis. Control variables included age, gender, sport type, and competitive experience. The results revealed that psychological capital negatively predicted burnout both directly ( β = -0.539, p <0.01) and indirectly (a*b = -0.803, p < 0.01) through coping strategies. Furthermore, perceived stress moderated both the relationship between psychological capital and coping strategies and the indirect effect of psychological capital on burnout via coping strategies. Notably, under high-stress conditions, the protective effect of psychological capital was more pronounced, with a more substantial indirect effect compared to low-stress conditions (β = -1.020, p < 0.01 vs. β = -0.299, p < 0.01). These findings underscore the importance of cultivating psychological resources and adaptive coping mechanisms to mitigate burnout, offering valuable insights for targeted interventions aimed at enhancing the well-being of athletes, particularly those experiencing elevated stress levels.
The Mediating Role of the Care Factor in the Effect of Nomophobia on Job Satisfaction in Nurses: a cross-sectional study
Authors: ÖNER Uğur , ASLAN Sinan , EKİNGEN Erhan
Published: November 2024

Background: This study aimed to reveal the mediating role of the Care Factor in the effect of nomophobia on job satisfaction in nurses.
Methods: The population of this descriptive, cross-sectional study consisted of nurses working in a province in the Southeastern Anatolia region of Turkey. A total of 1,083 nurses participated in the study, and the data were collected between May and September 2024. The data were gathered using the "Descriptive Form," "Fırat Nomophobia Scale (FNS)," "Care Factor Scale (CFS)," and the "Nurse Job Satisfaction Scale (JSSN)." Data were analyzed using the SPSS 25 program, with descriptive statistics, Pearson correlation, and regression analyses applied. Additionally, analysis was conducted using PROCESS macro version 4.0 (Model 4).
Results: It was observed that the Care Factor Scale—Caring for Self (CFS-CS) (-.063) and the Care Factor Scale—Caring of Manager (CFS-CM)(-.096) have a moderate mediating role in the effect of the Fırat Nomophobia Scale on the Job Satisfaction Scale for Nurses (JSSN).When the parallel mediation role was tested, the effect size increased to (-.159) and remained moderate.
Conclusion: In this study, a significant negative relationship was found between nomophobia and both job satisfaction and the Care Factor, while a significant positive relationship was found between the Care Factor and job satisfaction. Furthermore, the Care Factor was found to mediate the relationship between nomophobia and job satisfaction.
Still safe; still respectful: a mixed methods study exploring the early experiences of a rural community hospice in providing voluntary assisted dying
Authors: Auret Kirsten , Pikora Terri , Briand Beatriz Cuesta
Published: November 2024

Background
Voluntary assisted dying has become available as an end-of-life choice in many countries, including Australia. There is evidence on the mixed impact of voluntary assisted dying legislation on palliative care healthcare professionals, however, less is known about the interface between palliative care and voluntary assisted dying in smaller rural settings. This study explored the experiences of staff at a hospice in rural Western Australia in the two years following the implementation of voluntary assisted dying legislation.
Methods
A mixed-methods research methodology was used, with data collected via a brief anonymous survey and semi-structured interviews conducted with hospice staff in one rural location in Western Australia. Survey data was exported into SPSS and descriptive statistics were performed. Interviews were audio recorded and after deidentification, the transcripts were analysed thematically.
Results
A total of 30 participants took part in the survey and 10 were interviewed. The majority (n = 19) of survey respondents had been involved in voluntary assisted dying, yet only seven reported that their day-to-day role had changed. Supporting patient choice and autonomy were the most cited benefits of the introduction of voluntary assisted dying. Analysis of the qualitative data yielded three main themes: everyone is involved with patients accessing VAD; nothing changes but everything changes; and perceived support, education and training needs.
Conclusions
This study has described day-to-day work and experiences of those working in a small rural hospice which has integrated VAD into the care offered within the facility, observing there are subtle changes in the organisational atmosphere when VAD occurs. The education and support activities in place and the noted gaps may be a useful checklist for other hospices in the early phases of integrating VAD into their facility. Recommendations for future research are made.
Investigating miRNA-Driven DNA Methylation: Statistical Evidence of Gene-Specific Modulation
Authors: Jeon Seyeon , Jun Ha Ra , Lee Ji-Young , Sung Chang Ohk , CHUN SUNG-MIN
Published: November 2024

DNA methylation plays a crucial role in the epigenetic regulation of gene expression and is closely associated with the development of cancer. Abnormal regulation of gene expression due to changes in DNA methylation patterns of specific genes has been frequently observed in tumor cells. However, the specific mechanisms underlying the induction of DNA methylation in certain genes have not been fully elucidated. This study aimed to investigate the potential of microRNAs (miRNAs) as statistically significant regulators guiding promoter methylation of specific genes. MiRNAs are known to specifically recognize DNA sequences and exhibit various degrees of complementarity. We performed Spearman's rank correlation between the expression levels of 734 microRNAs and the CpG island methylation levels of 20,587 genes, collected from 813 cell lines in the Cancer Cell Line Encyclopedia (CCLE) database. Subsequently, we validated the dependent relationship between the selected target microRNAs and gene clusters using linear regression analysis. We identified 25 target genes in which promoter methylation was induced by the expression of four target miRNAs (hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-141) with statistically significant values. The correlations of the target pairs between methylation level of target genes and matched miRNAs were most pronounced in colorectal, gastric, lung, and ovarian cancers. Cancer-related genes, including ST14, OVOL1, and EPCAM, were identified as the target genes, confirming the possibility that promoter methylation of these genes is regulated by miRNA. Using bioinformatics-based screening analysis, we discovered target pairs that exhibited statistically significant changes in promoter methylation patterns due to specific miRNA expression. Furthermore, we confirmed the potential for miRNAs to regulate the expression of cancer-related genes through miRNA-induced promoter methylation. This expands our understanding of the mechanism underlying tumor development through methylation and provides a new perspective on the utilization of microRNAs in the field of cancer treatment.
The Reporting of Setting in Psychedelic Clinical Trials (ReSPCT) Guidelines: An international Delphi consensus study
Authors: Pronovost-Morgan Chloé , Greenway Kyle , Roseman Leor
Published: November 2024

Background
Psychedelic substances exhibit complex interactions with the ‘set and setting’ of use, i.e., the internal state of the user and the external environment in which a psychedelic experience takes place. Despite the known importance of these contextual variables, psychedelic research has suffered from methodological weaknesses in reporting extra-pharmacological factors and from a lack of consensus regarding their relative importance.
Methods
The study aimed to generate consensus-based guidelines for the reporting of settings in psychedelic clinical research, according to a diverse international group of psychedelic researchers, clinicians, and past trial participants. We conducted a large international Delphi consensus study composed of four iterative rounds of quasi-anonymous online surveys and facilitated debates.
Findings
Eighty-nine experts from 17 countries initially identified hundreds of potentially important psychedelic setting variables. These 770 responses were synthesized into 49 distinct items that were then rated, debated, and refined in subsequent rounds. The process resulted in 30 extra-pharmacological variables reaching pre-defined consensus thresholds: rated “important” or “very important” for reporting by at least 70% of experts. These items compose the Reporting of Setting in Psychedelic Clinical Trials (ReSPCT) guidelines, categorized into: physical environment, dosing session procedure, therapeutic framework and protocol, and subjective experiences. Emergent study findings reveal significant ambiguities in current conceptualizations of set and setting.
Interpretation
The ReSPCT guidelines and its accompanying explanatory document provide a new standard for the design and documentation of extra-pharmacological variables in psychedelic clinical research. Drug-context interactions warrant further attention to ensure the methodological rigor of psychedelic research.
Funding
Societal Engagement Seed Fund, Imperial College London.
Allelic variation and duplication of the dmrt1 were associated with sex chromosome turnover in three representative Scatophagidae fish species
Authors: Jiang Dongneng , Huang Yuan-Qing , Zhang Xinhui , Bian Chao , Jiao Kai-Zhi , Zhang Lin , Huang Yu , Yang Wei , Li Yu , Shi Gang , Huang Yang , Tian Changxu , Chen Huapu , Deng Si-Ping , Zhu Chun-Hua , Shi Qiong , Li Guang-Li
Published: November 2024

With known candidate sex-determining genes (male-specific dmrt1Ys), fish species of the family Scatophagidae are good models for studying sex chromosome evolution. Here, we analyzed sex chromosome turnover events in three representative fish species from two genera of the family Scatophagidae that have diverged 12.8 million years ago (Mya). Scatophagus argus and Sc. tetracanthus possess dmrt1Ys that arose from allelic variation before they diverged 7.2 Mya, and their loci are truncated dmrt1ΔX. The Y chromosome (Chr1) of Sc. tetracanthus is the result of the fusion of the original Y chromosome (Chr4) with an autosome (Chr13). The Selenotoca multifasciata dmrt1Y arose from a duplication of dmrt1 on Chr4 and then translocated to the new Y chromosome (Chr18). The different evolutionary trajectories of the dmrt1Ys were accompanied by sex chromosome turnover in these three species. The sex chromosomes of the Scatophagidae family have evolved rapidly, but not randomly.
A literature review on the benefits of wordless picture books for children’s development.
Authors: Goriot Claire , Jongstra Wenckje , Mensink Lotte
Published: November 2024

Wordless picture books contain no printed text, a narrative is conveyed solely through illustrations. Professionals are not always convinced of the usefulness of wordless picture books, and an overview of the benefits or disadvantages of these books is also lacking. The aims of this review study were to 1) investigate the benefits and/or disadvantages of wordless picture books for children’s development, and 2) provide an overview of the characteristics of research on using wordless picture books with children. A systematic search yielded 35 peer-reviewed articles on the use of wordless picture books with children (aged 0 to 12). These articles show that wordless books may benefit children’s speech and language development and their psychosocial development. Wordless books may also have a positive impact on children’s environment, which may in turn benefit child development. For example, adults seem to interact with wordless picture books in such a way that they provide the right preconditions for children’s language development. Research on wordless picture books is characterised by small-scale studies with young English-speaking children. Studies with larger and other participant groups are needed. Nevertheless, this study provides evidence that wordless picture books are a promising tool for benefiting children's development.
Resid�ncia agr�ria no semi�rido da Para�ba (Nordeste do Brasil): contribui��o para a forma��o do profissional das Ci�ncias Agr�rias
Authors: Melo Leandro Silva de , Santos Jos� Nailson Barros , Medeiros Robson Luis Silva de , Pimentel Diogo Jos� Oliveira , Barbosa Alex da Silva , Medeiros Marcos Barros de , Araujo Luis Felipe de
Published: November 2024

Este relato buscou validar a experi�ncia do Est�gio Interdisciplinar de Viv�ncia em Resid�ncia Agr�ria como etapa da materializa��o do conhecimento e forma��o do profissional de Ci�ncias Agr�rias em comunidades rurais. A metodologia foi executada em tr�s etapas: (i) preparat�ria do discente para a viv�ncia: discuss�o dos m�todos de coleta de dados e observa��o da realidade das comunidades rurais; (ii) viv�ncia coparticipa��o e troca de saberes: onde se realizaram as observa��es, conforme costumes dom�sticos, aspectos de produ��o agr�cola, padr�es de consumo, colheita, beneficiamento e comercializa��o; (iii) diagn�stico rural participativo: car�ter avaliativo e descritivo com compartilhamento de saberes dos discentes. A resid�ncia agr�ria com a materializa��o do Est�gio Interdisciplinar de Viv�ncia contribui na constru��o de experi�ncias para a educa��o do campo. A imers�o na realidade prepara e qualifica os futuros profissionais de Ci�ncias Agr�rias para a transforma��o da sociedade rural, fortalecendo os meios de coopera��o, interven��o e coparticipa��o e forma��o mais s�lida junto � comunidade rural. Sugere-se que o Est�gio Interdisciplinar de Viv�ncia em Resid�ncia Agr�ria deve ser inserido como um componente pedag�gico dentro do curr�culo em Cursos de Ci�ncias Agr�rias no pa�s.