bluuebunny/crossref_metadata_2025 huggingface dataset:
The microbiological quality of minced pork treated with garlic in combination with vacuum packaging
Authors: Kunová Simona , Haščík Peter , Lopašovský Ľubomír , Kačániová Miroslava
Published: May 2021

The present study aimed to evaluate the microbial quality of minced pork treated with fresh garlic, dried garlic, and garlic oil in combination with vacuum packing. The growth of Total Viable Counts (TVC), Coliform Bacteria (CB), and Pseudomonas spp. were evaluated. The microbiological analyses were performed by the plate dilution method. The average value of TVC was 8.45 log CFU.g-1 in aerobically packed samples, 5.59 log CFU.g-1 in samples treated with garlic oil, 5.36 log CFU.g-1 in vacuum packed samples, and samples treated with dried garlic, and 4.98 log CFU.g-1 in samples treated with fresh garlic on 8th day of storage. The number of TVC was significantly lower in samples treated with fresh garlic compared to samples treated with dried garlic and garlic oil on the 8th day of storage (p <0.05). The average value of CB was 4.13 log CFU.g-1 in aerobically packed samples, 1.82 log CFU.g-1 in samples treated with garlic oil, the value of CB in vacuum packed samples, in samples treated with fresh garlic and also with dried garlic was lower than 1.00 log CFU.g-1 on 8th day of storage. The number of CB was significantly higher in aerobically packed samples and samples treated with garlic oil compared to vacuum-packed samples, samples treated with fresh garlic and dried garlic on the 8th day of storage (p <0.05). The average number of Pseudomonas spp. was 2.45 in aerobically packed samples, count of Pseudomonas spp. was lower than 1.00 log CFU.g-1 in vacuum packed samples and in the sample with garlic on the 8th day of storage. The number of Pseudomonas spp. was significantly higher in aerobically packed samples in comparison with vacuum-packed samples, samples with fresh garlic, dried garlic, and garlic oil (p <0.05).
Ascorbic acid supplementation suppresses cadmium-derived alterations in the fission yeast Schizosaccharomyces pombe
Authors: Kovár Marek , Navrátilová Alica , Trakovická Anna , Požgajová Miroslava
Published: May 2021

Cadmium (Cd) a highly toxic environmental pollutant, that does not have any physiological function in the organism, represents a great concern for human health as it can be easily transported from its environmental sources to the food chain. Food, water, and air are the major sources of Cd exposure to the population. Cd-mediated impairments of the basic cellular properties largely depend on its ability to enhance the formation of reactive oxygen species (ROS) and thus triggers oxidative stress to the cell. With the use of fission yeast Schizosaccharomyces pombe (S. pombe) as the model organism, we have analyzed the impact of Cd on the cell growth intensity, as it represents the fundamental feature of all living organisms. Cells were incubated with different Cd concentrations for 3, 6, and 9 hours to investigate the effect of Cd on cell growth in a time and dose-dependent manner. Further possible Cd-derived alterations, as the peroxidation of membrane lipids or the functional impairment of the enzymatic antioxidant protection mechanisms, were investigated by determination of the MDA content and via catalase (CAT) activity detection. Moreover, ascorbic acid (AsA) pre-treatment was subjected to investigate the assumed positive effect of AsA against Cd toxicity. We show here on one hand that cells suffer under the influence of Cd, but on the other hand, they substantially profit from AsA supplementation. Because S. pombe is known to shares many molecular, and biochemical similarities with higher organisms, the effect of AsA in cadmium toxicity elimination might be expected to a similar extent also in other cell types.
Necesitatea aplicării cunoștințelor de genetică moleculară în gestionarea resurselor genetice forestiere din Republica Moldova
Authors:   ", Postolache Dragos ,   Alexandru Ciubotaru",   National Botanical Garden (Institute)
Published: May 2021

Molecular genetics plays a crucial role in the assessment of forest genetic resources. Using recently acquired genetic knowledge based on molecular markers, can contribute significantly to the development of advanced strategies for in-situ dynamic conservation of forest genetic resources in the Republic of Moldova.
Componența substratului pentru aclimatizarea vitroplantulelor de goji
Authors:   ", Trofim Mariana ,   Alexandru Ciubotaru",   National Botanical Garden (Institute), Ciorchina Nina ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Tabara (Gorceag) Maria ,   "Alexandru Ciubotaru" National Botanical Garden (Institute)
Published: May 2021

The survival of wolfberry plantlets obtained by tissue culture, under ex vitro conditions, depends directly on the artificially created environmental conditions at stage I of acclimatization: protection from water stress, excessive sunlight, thermal extremes, air currents and establishing an optimal substrate for adequate growth.
New data on rare species Digitalis lanata Ehrh. (Scrophulariaceae) in the Republic of Moldova
Authors:   ", Belous Stefan ,   Alexandru Ciubotaru",   National Botanical Garden (Institute), Izverscaia Tatiana ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Munteanu Mihaela ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Ciocarlan Nina ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Ghendov Veaceslav ,   "Alexandru Ciubotaru" National Botanical Garden (Institute)
Published: May 2021

The description of extant wild population of Digitalis lanata Ehrh. in the vicinity of vill. Nimoreni, Ialoveni distr. (N 47° 00’ 03”, E 28° 39’ 38”), some morphometric parameters, density of individuals and the attempts of ex-situ propagation with the aim of reintroduction into the natural biotope is presented.
Convolvulus cantabrica L. (Convolvulaceae) in the «Lower Prut» Biosphere Reserve (Republic of Moldova)
Authors:   Natural Scientific Reserve” Lower Prut”, Republic of Moldova, Cassir Polina , Izverscaia Tatiana ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Ciocarlan Nina ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Ghendov Veaceslav ,   "Alexandru Ciubotaru" National Botanical Garden (Institute)
Published: May 2021

The morphometric parameters, density of individuals, reproductive strategy and the ability of adaptation of the populations of Convolvulus cantabrica L. in the “Lower Prut” Biosphere reserve (Cahul district) were studied. There were registered 7 fragmented populations (the biggest being cca 0,5 ha).
Pilosella flagellaris (Willd.) Arv.-Touv. (Asteraceae) – vulnerable taxon in the flora of the Republic of Moldova
Authors:   ", Ionita Olga ,   Alexandru Ciubotaru",   National Botanical Garden (Institute)
Published: May 2021

New data on the distribution and the study of the populations of the rare species Pilosella flagellaris (Willd.) Arv.-Touv. (Asteraceae) in the natural habitats of the Republic of Moldova are presented in the article.
Contribuții la studiul productivității și calității unor pajiști din Parcul Național Orhei
Authors:   ", Miron Aliona ,   Alexandru Ciubotaru",   National Botanical Garden (Institute), Titei Victor ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Teleuta Alexandru ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Pavliuc Alina ,   "Alexandru Ciubotaru" National Botanical Garden (Institute)
Published: May 2021

The paper presents data on the production and biochemical composition of hay of some types of grasslands in Orhei National Park in the conditions of 2020 year.
Specii de Digitalis L. în Grădina Botanică Națională – aspecte de conservare și cultivare ex-situ
Authors:   ", Munteanu Mihaela ,   Alexandru Ciubotaru",   National Botanical Garden (Institute), Belous Stefan ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Izverscaia Tatiana ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Ghendov Veaceslav ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Ciocarlan Nina ,   "Alexandru Ciubotaru" National Botanical Garden (Institute)
Published: May 2021

The paper presents scientific data on 4 species of the genus Digitalis L. (D. lanata Ehrh., D. grandiflora Mill., D. purpurea L. and D. ferruginea L.). The bibliographic study was performed regarding the multiplication methods, biological aspects and the conservation strategies of rare species. Phenological observations and biometric measurements were performed and the behavior of the plants under cultivation conditions was monitored. The preliminary results demonstrated the perspective of ex-situ cultivation and conservation.
Note floristice din Rezervaţia Știinţifică „Codru”
Authors:   ", Pinzaru Pavel ,   Alexandru Ciubotaru",   National Botanical Garden (Institute), Cantemir Valentina ,   "Alexandru Ciubotaru" National Botanical Garden (Institute), Jardan Natalia ,   “Codru” Scientific Reserve, Republic of Moldova
Published: May 2021

Three new species of the flora of the “Codru” Scientific Reserve have been detected: Artemisia pontica L., Centaurea stereophylla Besser, Crataegus ucrainica Pojark. and new sites where some rare species grow have been identified.
Introduction and improvement of ornamental plants: history, current affairs and trends
Authors:   ", Sirbu Tatiana ,   Alexandru Ciubotaru",   National Botanical Garden (Institute)
Published: May 2021

In this paper are briefly presented the results of the Laboratory Ornamental Plants for 70 years since its existence. Mobilization, research and adaptation, conservation and sustainable use of plant diversity are the main objectives of the laboratory. During this period a rich genofond was accumulated (over 1700 intraspecific taxa), the largest and most diverse in the country, exhibited in unique collections: non-traditional perennials, annuals, rare plants; generic collections (Paeonia L., Hemerocallis L., Hosta Tartt., Chrysanthemum L. etc.). The accumulated genetic fund serves as a basis in the breeding activity, which resulted in the creation of hundreds of forms, hybrids of ornamental plants. Over 200 cultivars have been tested, approved, some - certified with certificates for varieties or patented.
The Introduction of Greenhouse Plants in the “Al. Ciubotaru” National Botanical Garden (Institute)
Authors:   ", Timbali Valentina ,   Alexandru Ciubotaru",   National Botanical Garden (Institute)
Published: May 2021

The “Greenhouse Plants” Laboratory was founded in 1983 according to the Decision of the Presidium of the ASM. For about 50 years, in the “Al. Ciubotaru” National Botanical Garden (I), the collection of tropical, subtropical and succulent plants was developed so that by the end of 2020 it counted 3069 taxa, belonging to 133 families and 589 genera. The gene pool includes representatives of the phyla Psilotophyta, Lycopodiophyta, Polypodyophyta, Pinophyta, Cycadophyta and Magnolyophyta, with the classes Magnoliopsida and Liliopsida. The collection of succulents is the largest – about 1700 taxa (including the family Cactaceae with 1009 taxa), the group of subtropical plants consists of 505 taxa and tropical plants 857 taxa.
The Big Mac Index Dynamics
Authors: Chen Yu-Tsang , Li Amy
Published: May 2021

The Big Mac Index is a tool that makes exchange-rate theory more palatable. In recent years the Big Mac Index has been used as a practical way to determine the over- or under-valued international currencies according to the theory of Purchasing Power Parity. The theory uses the Big Mac as a tradable single-good basket to equalize the Dollar-value of the hamburger around the world through arbitrage. The enormous popularity of the Big Mac Index arose the questions of how effective the Big Mac price is as an indicator of income level and how accurate the exchange rate movement predictions are based on the Big Mac prices over time? The statistical analysis of this paper is implemented using data from 2013 to 2020 from The Economist and from the World Bank for 42 countries. US Dollar, Euro, British Pound, Chinese Yuan, and Japanese Yen are used as base currencies to track the dynamics of stability and convergence. As a qualitative indicator of movement in the nominal exchange rate, however, there is no significant difference in countries of different income levels and economic stability. The Big Mac Index estimation consists with previous studies in convergence for countries with high income level. Contradictory to previous studies, the Big Mac Index estimation tends to fluctuate for currency in country with high income level like US Dollar only in 2020. The stability of Big Mac Index dynamics from 2013 to 2020 holds for the rest of the other four currencies.
COVID-19 Pandemic on China’s Economy: Impacts and Suggestions
Authors: Feng Jing , Liao Wen-Chao
Published: May 2021

COVID-19 has caused an uproar in China and around the world since the end of 2019. It is coming violently, and it has serious impacts on the Chinese economy since the time of the Chinese New Year. With the passage of time, in the spring of 2020, the new virus ravaged the world’s major economies; the world would fall into recession in 2020, and the financial markets had fluctuated sharply. “Taking back time and making up for the loss” is China’s general tone for promoting economic and social development in the context of the current epidemic (Chen, Dou, & Long, 2020). How to get rid of the adverse effects of the epidemic on the society and to promote better social development are topics of practical significance. We study the background of the epidemic which impact on China’s domestic and foreign economic, as well as the fluctuations in the world economy. We analyze various economic issues arising in the current context, investigate relevant data, apply the Mundell effective market classification principle for relevant analysis, and put forward reasonable suggestions accordingly.
Research on the Impact of Takeout Platform’s Electronic Service Quality on Customer Loyalty
Authors: Zhang Ju-Xiang , Sun Hui-Jie
Published: May 2021

This paper analyzed the influence of electronic service quality of takeout platform on customer loyalty. The results showed that the ease of use, food safety, performance, privacy, interactivity, compensation and diversity of service quality of takeaway platform had a positive impact on customer loyalty. Customer satisfaction played an intermediary role between electronic service quality and customer loyalty. Based on the results, this paper put forward some advices such as improving delivery speed, improving the safety quality, protecting user information security, expanding service categories, and improving operational efficiency to enhance service quality as well as customer loyalty.
The Impact of Trade Liberalization on the Environment: A Case Study of Fujian Province, China
Authors: Jin Qiao-Ling , Liu Li
Published: May 2021

With the rapid development of international trade and the continuous deterioration of the environment worldwide, the issue of impact of trade on energy consumption and pollution emissions has drawn widespread attention of the international community. Theoretical circles have different views on the impact of trade liberalization on the environment. The hypotheses of “Pollution Haven” and “Environmental Factor Endowment” are both representative theories. Based on the revised input-output model, this paper estimates the trade embodied carbon emissions of import and export commodities in Fujian Province from 2008 to 2016. The results show that Fujian Province is a net export region with implicit carbon emissions, and there is a significant pollution surplus in international trade. But because the embodied carbon pollution per unit of imports is greater than the embodied carbon pollution per unit of exports, the terms of trade for carbon emissions are less than 1. Therefore, the hypothesis of “Environmental Factor Endowment” can explain the environmental impact of Fujian’s trade liberalization better than the “Pollution Haven”.
Precision Marketing Strategies for Small and Medium-sized Clothing E-commerce Enterprises Based on Big Data
Authors: Chang Yu-Chung
Published: May 2021

Based on the big data analysis technology of small and medium-sized clothing e-commerce enterprises, this paper provides theoretical and practical methods for e-commerce enterprises to apply big data technology. The data sources come from questionnaires and online data grab. Through the Google online questionnaire survey, 252 valid questionnaires were received. Python is used to search valid reviews on Tmall and Internet with some keywords, and a total of 11,864 valid comments were obtained. We find that the reason why men buy clothes is as high as 68% because of the seasonal change, but only 31% of women buy clothes because of the seasonal change. The higher the average monthly income of women, the more attention is paid to whether the style of clothing design is suitable for themselves, and the more attention is paid to the service attitude of e-commerce enterprises. From decision tree analysis, the fit of clothing style is the most important factor affecting the shopping choice of customers. From the data of customer reviews, the most mentioned variables are clothing style, fashion, service attitude and price. The number of reviews and the sentiment analysis score on clothing style are all ranking first. The number of reviews and the sentiment analysis score on clothing fashion are all ranking second. We also proposes corresponding precision marketing strategies based on the results of big data analysis, such as gender recommendation strategies, personalized recommendation strategies, differentiated marketing strategies, enterprise training and clothing design strategies.
Social-Emotional Learning and At-Risk Children and Youth
Authors:   Indiana University South Bend, Larrier Yvonne , Lewis Tinisha ,   GCSCORED
Published: May 2021

More and more, behaviors of children, youth, and communities are being classified as at-risk in societies locally and globally. Behaviors associated with the at-risk classification are aggression at home, school and in the community, underperformance and underachievement at school, and truancy. Acquiring social emotional competencies (SECs) is an effective way of diminishing and eventually eliminating these behaviors. Acquiring these SECs from as early as kindergarten acts as a protective factor against maladaptive and risky behaviors later on in life. Social emotional education, or learning, is the acquisition of five core skills: self-awareness, self-management, social awareness, responsible decision-making, and relationship skills. As children and youth acquire these skills, they are better able to relate to themselves, others, and situations. These highly developed SECs can be seen in children’s enhanced academic achievement and performance, decreased incidents of violence, improved school attendance, and empathy.
RE-CONCEPTUALIZING EDUCATION INTERVENTIONS: FRUIT TO ROOT AND SILOS TO SYSTEMS
Authors:   Indiana University South Bend, Larrier Yvonne
Published: May 2021

Can you help our school district/corporation increase student achievement and student attendance and decrease suspensions? Too many of our K-12 grade students are coming to school having lived through, and still living through, traumatic challenges at home and in their communities. For many, trauma is visited upon them early and is a frequent daily occurrence. These traumatic student experiences show up in the classroom in a variety of ways, such as aggression toward peers and adults, self-harm, inattentiveness, drug and alcohol use, failing grades, etc. As a result, these non-productive behaviors impede learning for the students and can cause our educators to feel ill-equipped and ineffective as they teach students who exhibit them.
WORKING WITH NON-COMPLIANT CLIENTS: A STAGES OF CHANGE APPROACH FOR ENGAGING CLIENTS IN TREATMENT
Authors: Linton Jeremy M.
Published: May 2021

Client non-compliance in counseling has long been discussed in the literature (e.g, Miller & Rollnick, 2012). This is especially true in the areas of addiction, assaultive behaviors, and extrinsically motivated reasons for seeking treatment (Lee, Sebold, & Uken, 2003; Linton, Bischof, & McDonell, 2005). There are, though, many other explanations for client non-compliance with counseling interventions. In this article, client non-compliance in counseling is conceptualized and methods for working with that non-compliance are discussed. First, client non-compliance is defined as it pertains to participation and follow-through with treatment recommendations. Following this, suggestions for addressing client non-compliance in counseling are offered. These discussions are framed within Prochaska and DiClemente’s (1984) Transtheoretical model, also known as the Stages of Change approach. These suggestions will focus on techniques for use by counselors designed to increase client compliance with treatment. A case vignette is provided to enhance this discussion.
Small-scale agricultural product marketing innovation through BUMDes and MSMEs empowerment in coastal areas
Authors: Syahza Almasdi , Savitri Enni , Asmit Brilliant , Meiwanda Geovani
Published: May 2021

A region’s economic growth depends on the development policies based on the wealth determined from the potential of human, institutional and local resources. Furthermore, tThe development needs to link primary sectors with future processing to increase agricultural products’ added value and marketing competitiveness. This study develops an innovative marketing model in agricultural products for small-scale farmers through village-owned enterprises (BUMDes) and micro, small, and medium enterprises (MSMEs) empowerment in coastal areas. One way of realizing this program is by building agribusiness and agro-industry partnerships that are well-planned and associated with other economic sectors' development. The partnership involves community economic institutions, including BUMDes, credit institutions, farmer entrepreneurs, as well as Micro, Small, and Medium Enterprises. BUMDes is a rural-based business with a legal entity managed by the village government to create added value for the community’s agricultural products. Together with MSMEs, these businesses need to support the agribusiness subsystem's development, including trading in agricultural production facilities and business activities. Furthermore, they need to promote agricultural production, support services, a source of market information for rural communities, the main actors of appropriate technology for agricultural products.
The effect of intangible service quality on retailing during the COVID-19 pandemic in Saudi Arabia
Authors: Alzaydi Zyad
Published: May 2021

The purpose of this study is to investigate how online to offline service quality influences the customer’s perceived risk and trust towards the retailer and how these factors impact customer satisfaction and intention to revisit. The present study incorporates intangible service quality offline aspects, such as empathy, and online aspects, such as mobility. The objective of the research is to examine the integration of online to offline service quality models in Saudi Arabia during the COVID-19 pandemic, using key aspects of offline, online and mobile service quality. The data was collected using an online survey of 289 respondents from Saudi Arabia. The analysis was conducted using partial least square and structural equation modelling. This study finds that the intangibility of service quality has a positive impact on perceived trust; however, the direct relationship between the intangibility of service quality and perceived risk is not supported. The study’s results support the hypothesis that customer satisfaction has a positive impact on the intention to revisit and that received trust positively affects satisfaction. The results have implications for service managers in the retailing and e-commerce sectors and offer a better understanding of how different channels of service affect customers’ perceptions and intentions to revisit.
Drivers, barriers and incentives to implementing environmental management systems in the manufacturing industry
Authors: Mabrouk Nejah Ben , Ibrahim Saber
Published: May 2021

Industrial development has made major breakthroughs in the last decade in the wake of increased production, government policies and public demand. At the same time, problems related to environmental sustainability have become a major concern for producers. The unsatisfactory dimension of environmental protection has always been highlighted, because the environmental management system (EMS) is ignored and not consistently implemented in certain Tunisian companies. This increasing interest in environmental consciousness is pushing manufacturers to aspire to adopt successful environmental management strategies. Organizations are in fact increasingly responsible for monitoring and enhancing their environmental efficiency. The present work is intended to resolve these issues by establishing the essential factors and modelling their interrelationships in the Tunisian context. By reviewing literature and expert opinions, 14 critical factors have been identified which leads to responsive in the implementation of EMS- based ISO 14001. For better understanding, the MICMAC research was used to identify the critical variables according to their driving and dependence power. The present study highlights “Top management commitment and support” and “Government policies and legislation” as the most significant factors for ISO 14001 implementation. This research will facilitate organizations' readiness for implementation of ISO 14001 by providing a detailed understanding of mutual relationships among EMS factors based on ISO 14001.
A study on the success factors for knowledge management in supply chains of electronics industry
Authors: Rattanawiboonsom Vichayanan
Published: May 2021

This research aimed to 1) study the success factors for knowledge management through electronics industry supply chains, and 2) study guidelines and recommendations regarding the success factors for knowledge management through electronics industry supply chains. The study employed the quantitative research methodology. The statistical devices used included frequency, percentage and Structure Equation Modeling (SEM). The population and sample group comprised executives of the electronics industry in the electronics and electrical appliances sector in Thailand. The results revealed that the factors regarding the information technology system, leadership support and knowledge management had positive effects on the success of the knowledge management through electronics industry supply chains with the statistical significance (β) of 0.519, 0.621 and 0.448, respectively. However, the factors regarding human resource management affected the success of the knowledge management negatively at the statistical significance of 0.323. As for the effects of variables on the success of the knowledge management, it was found that the factors with the most positive indirect effects (IE) and total effects (TE) were those regarding 1) leadership support (IE = 0.278, TE = 0.278), 2) information technology system (IE = 0.233, TE = 0.233), and 3) knowledge management, which had a positive direct effect (DE) at 0.448 and a total effect (TE) at 0.448. However, the factors regarding human resource management had a negative indirect effect (IE) on the success of the knowledge management at -0.145.
The effect of supply chain integration on hotel performance through green supply chain management
Authors: Tarigan Zeplin Jiwa Husada , Andreani Fransisca , Basana Sautma Ronni
Published: May 2021

Internal and external integration in hotel industries is essential to improve Green Supply Chain Management (GSCM) to maintain hotel performance and sustainability. This research is to examine the impact of internal and external integration on GSCM and hotel performance. It is quantitative research with judgmental sampling. Questionnaires were distributed to 72 hotel employees from 62 hotels of three-star hotels and above, who understand GSCM and hotel performance in East Java. But 66 questionnaires were returned, and only 62 questionnaires were valid for data analysis. Structural Equation Modelling (SEM) is used to analyze with the help of Java Web Start software. The results show that all six hypotheses are supported, internal integration with Use technology to significantly determine plans and coordination capable of external integration and GSCM. External integration with Sharing knowledge with partners and Collaborating in solving problems can improve GSCM significantly. Supply chain integration, which consists of internal integration and external integration, impacts hotel performance by reducing hotel waste and Efficient use of resources. GSCM in implementing Eco green, green procurement and product life cycle have a significant impact on improving hotel performance.
Process Validation of Isoniazide and Rifampin Tablet
Authors: Kailas Borse Priyanka , Dhamak Kiran B.
Published: May 2021

The plethora subscribed in this research is directed towards the process validation of tablet formulation containing Isoniazide and Rifampin. The different process parameters were identified and studied for the tablet formulation batches. Three process validation batches of same size, manufacturing process, equipment and validation criteria was taken. The critical parameter involved in sifting, dry mixing, preparation of granulating agent, wet mixing, wet milling, drying, sizing, lubrication and compression stages were identified and evaluated. The outcome indicated that this process validation data provides high degree of assurance that manufacturing process produces product meeting its predetermined specifications and quality attributes.
Targeting influenza at the Topologically conserved substructures
Authors: Ahamed Zubair , Kamjula Vandana , Kakunuri Bhuvaneswari
Published: May 2021

H9N2 avian influenza virus is a low pathogenic endemic strain in the domestic poultry of most of the Asian countries. Attempts have extensively failed in eradicating its diverse strains. To find the drug against the evolutionarily conserved substructures, the target protein sequence is analyzed through sequence and modelled structure for mapping the structurally conserved topology. The available drugs are screened against the deciphered topological map through the predicted ADMET and drug-likelihood scores. This study helps to build a theoretical framework to make the foremost potent drug.
Patient with Diabetes Mellitus and Ocular Complications: A Brief review
Authors: K L Naveen , Josvi Veigas Grinton , Bhattacharjee Ananya
Published: May 2021

Diabetes mellitus is metabolic disorder characterised by hyperglycaemia of human blood due to inadequate secretion and action of hormone insulin. Different classes of DM are Type-1, Type-2, neonatal, gestational and maturity onset of diabetes at young stage. The main pathologic cause for the DM is autoimmune destruction of β-cells and insulin deficiency due to resistance of insulin action caused by the abnormalities in metabolism of carbohydrates, protein and lipids which intern cause lack of insulin action on target tissues. Chronic stage of hyperglycaemia is associated with permanent damage, failure and dysfunction of various organs system, which includes heart, blood vessel, eyes, neurones and kidney. Long term DM may causes some health complications in patient such as nephropathy, neuropathy, retinopathy and other complications like peripheral vasculopathy and ischemia of heart. In current era ocular complications associated with DM are rapid and progressive, becoming world top most cause of morbidity. This article covers brief information regarding ocular complications and vision loss in patient with DM.
ظاهرة التضاد في معجم متن اللغة دراسة في التغير الدلالي
Authors: Aamir Muhammad Muhammad , Ismail Alewi Hayam
Published: May 2021

الحمد لله من أول الدنيا إلى فنائها ومن الآخرة إلى بقائها وصل اللهم على محمد خير الأنام وعلى آله الطيبين الطاهرين الكرام أهل الذكر وأولي الأمر وبعد:

أن ظاهرة التضاد في اللغة العربية وغيرها من اللغات لها أهمية كبيرة في استيضاح معاني الكلمات, وهذا ما دعى الباحثين في هذا الشأن أن يغوصوا في أعماق بحر اللغة بحثاً عن المفردات المتضادة ودلالتها على معانيها, ولم يكن البحث في هذا الموضوع مقتصر على جيل معين, فقد بحث فيه القدامى والمحدثين على حد سواء, وكل منهم توصل إلى ما توصل إليه في هذا الشأن, فاكتنفت هذه الظاهرة( التضاد) آراء منها ما كان ينكر هذه الظاهرة ومنها مؤيد ومنها ينكر أو يؤيد لكن بقيود وشروط ومنهم من حدد هذه الظاهرة بظروف معينة, ونحن نستعرض في هذا البحث البسيط اهتمام الشيخ أحمد رضا العاملي(ت1372م) بهذه الظاهرة في معجمه متن اللغة, فقد زخر هذا المعجم بالعديد من الظواهر اللغوية وكان من ضمنها ظاهرة التضاد, ويعني بها وجود كلمتان مختلفتان متضادتان لفظاً ومعنى كالفرح والحزن, مما يلحظ أن الشيخ قد نبه عليها في معجمه بصورة واضحة وجلية من خلال استخدامه بعض العبارات المعبرة عن التضاد منها( مقابل ونقيض وخلاف مكان ضد).

سأتناول في هذه الصفحات المتواضعة مطلبين لدراسة التضاد، الأول: الجانب النظري: تتناول الباحثة فيه: مفهوم التضاد، وموقف اللغويين منه، وأسباب نشوء التضاد في اللغة، وأنواع التضاد . والثاني: الجانب النظري: تتناول الباحثة فيه تحليل بعض الأمثلة في المادة المدروسة لمعجم متن اللغة .
وليم سيدني كريفز ودوره في قيادة الحملة الأميركية في سيبيريا عام 1918م
Authors: عبد الحسن حسين حسين
Published: May 2021

تطرق البحث لحياة القائد العسكري وليم سيدني كريفز منذ ولادته عام 1865م و رعاية والده له ودراسته, ثم التحاقه في أكاديمية كاديت التي كان لها أثر بارز في صقل شخصيته , تدرج في المراتب وخدم في أماكن عدة لا سيّما الحرب الإسبانية الأميركية 1898م, و القضاء على التمردات في الفلبين 1902م, و في عام 1918م أسندت له قيادة الحملة الأميركية في سيبيريا التي كانت وفق أسباب تتعلق بشخصيته , واجه كريفز العديد من العقبات منها تواجد قوات الحلفاء التي حاولت تقطيع أوصال روسيا , لا سيما دعم اليابانيين للأدميرال كولتشاك الذي أعلن نفسه حاكما لسيبيريا , ولكن كريفز بحنكته و شخصيته استطاع أن يحافظ على الأهداف التي رسمتها له الرئاسة الأميركية و يمنع الحلفاء من احتلال أي جزء من روسيا , لغاية انتهاء الحملة في تشرين الثاني 1918م .
Đặc điểm lâm sàng và chẩn đoán điện tổn thương dây thần kinh đoạn cẳng tay ở đối tượng giám định thương tích
Authors: Hiếu Đỗ Lập , Hưng Nguyễn Trọng , Tuấn Đào Quốc
Published: May 2021

Các dây thần kinh ở vùng cẳng tay trong các vụ giám định thương tích thường được phát hiện tổn thương khi đến giám định mà trước đó không được chẩn đoán và xử trí. Nghiên cứu nhằm mô tả triệu chứng lâm sàng, mức độ tổn thương và đánh giá bất thường trên chẩn đoán điện của các dây thần kinh trụ, giữa, quay ở vùng cẳng tay trên 30 người bệnh giám định thương tích tổn thương một hoặc nhiều dây. Tất cả các bệnh nhân đều được hỏi bệnh, khám lâm sàng thần kinh, đánh giá mức độ tổn thương thần kinh dựa trên thang điểm Quick DASH và thăm dò chẩn đoán điện bằng đo tốc độ dẫn truyền thần kinh cùng ghi điện cực kim. Kết quả nghiên cứu cho thấy tổn thương ưu thế tay trái (60%), trong đó vị trí ở 1/3 trên cẳng tay là 46,7%. Tổn thương hỗn hợp vận động và cảm giác chiếm tỷ lệ cao nhất (74%). Điểm Quick DASH thấp nhất 16, cao nhất 48 và trung bình là 31,4, trong đó tỷ lệ các mức độ nhẹ, vừa và nặng theo thứ tự là 20%, 40% và 40%. Các bất thường trên thăm dò chẩn đoán điện ghi nhận giảm tốc độ dẫn truyền và giảm biên độ đáp ứng một cách rõ rệt tại các dây thần kinh trụ, giữa, quay ở vùng cẳng tay ở bên tổn thương. Biểu hiện mất chi phối thần kinh cơ có tỷ lệ thấp ở nhóm không được khâu nối dây thần kinh và không có sự khác biệt về tốc độ dẫn truyền, biên độ giữa bên bị bệnh và bên lành ở 3 nhóm điều trị được nối vi phẫu, nối không vi phẫu và không được nối dây thần kinh. Kết luận: Tổn thương ưu thế tay trái, chủ yếu dây trụ và quay; mức độ tổn thương là vừa và nặng (theo thang điểm Quick DASH). Trên chẩn đoán điện, tổn thương rõ hỗn hợp myelin - sợi trục ở các dây thần kinh vùng cẳng tay bên bệnh và không khác biệt về sự chệnh lệch giữa 3 nhóm điều trị. Tổn thương mất chi phối thần kinh cơ có tỷ lệ thấp ở nhóm không được nối thần kinh.
Kết quả điều trị hội chứng rối loạn sinh tủy bằng decitabine tại Viện Huyết học - Truyền máu Trung ương
Authors: Hảo Nguyễn Quang , Anh Trần Tuấn , Hương Lưu Thị Thu , Phương Vũ Minh , Bình Vũ Đức , Dũng Nguyễn Ngọc , Thanh Nguyễn Hà , Khánh Bạch Quốc , Chính Dương Quốc
Published: May 2021

Hội chứng rối loạn sinh tủy là một nhóm bệnh lý ác tính của tủy xương. Việc chẩn đoán và điều trị bệnh tương đối phức tạp. Những năm gần đây, các thử nghiệm lâm sàng sử dụng các thuốc giảm methyl hóa đã cho kết quả đầy hứa hẹn, mà điển hình trong đó là decitabine. Mục tiêu của nghiên cứu là đánh giá kết quả điều trị bằng phác đồ decitabine đơn trị trên bệnh nhân hội chứng rối loạn sinh tuỷ ở Viện Huyết học - Truyền máu Trung ương. Đối tượng nghiên cứu là 43 bệnh nhân được chẩn đoán hội chứng rối loạn sinh tủy theo WHO 2016 tại viện Huyết học - Truyền máu Trung ương từ 2018 đến 5/2020. Các bệnh nhân được phân nhóm nguy cơ theo tiêu chuẩn IPSS - R và được điều trị bằng phác đồ decitabin đơn trị. Nghiên cứu đã thu được một số kết quả như sau: tỷ lệ đáp ứng toàn bộ là 60,5%, trong đó 41,9% lui bệnh hoàn toàn và 18,6% lui bệnh một phần. Thời gian sống toàn bộ của bệnh nhân là 25,6 ± 2,9 tháng. Thời gian chuyển cấp trung bình ở 9 bệnh nhân là 21,8 tháng. Các tác dụng không mong muốn ở máu ngoại vi gồm giảm bạch cầu trung tính, giảm tiểu cầu và giảm hồng cầu với tỷ lệ lần lượt là: 27,9%, 18,6% và 41,9%. Có 9 tác dụng phụ khác thường gặp với tỷ lệ ở nhóm bệnh nhân nghiên cứu như sau: chán ăn 46,5%, đau đầu 37,2%, táo bón 32,6%, nôn 27,9%, ho 23,3%, sốt 18,6%, tăng men gan 18,6%, tiêu chảy 16,3% và viêm phổi kẽ 16,3%. Kết quả từ nghiên cứu này cho thấy phác đồ điều trị decitabine đơn trị đã cải thiện rõ tỷ lệ đáp ứng điều trị, kéo dài thời gian sống thêm với một số tác dụng không mong muốn thường gặp.
Las Anotaciones de Herrera a Garcilaso como texto polémico: aspectos materiales, editoriales y autorialesHerrera’s Anotaciones to Garcilaso as a Polemical Text: Material, Editorial and Authorial Aspects
Authors: Montero Juan
Published: May 2021

Herrera’s commented edition of Garcilaso de la Vega’s works advances an innovative formula in comparison to El Brocense’s edition in material and editorial aspects. Our analysis shows that with those innovations Herrera strove to underscore his authorial role (against Garcilaso and El Brocense) and his attempt to hijack the leadership of Spanish letters with the help of the group of Seville learned men who supported him. Under his nationalist discourse lurks, therefore, controversy and the rivalry between regional groups (Andalusians against Castilians) and social tiers (men of letters against nobles).
Poética y polémica en la poesía de Bartolomé Leonardo de ArgensolaPoetic and Polemic in Bartolomé Leonardo de Argensola’s Poetry
Authors: D’Agostino Maria
Published: May 2021

Bartolomé Leonardo de Argensola never took part in the polemic typical of his own time, but this attitude did not prevent him from expressing his disapproval of Góngora. Thus far critics have always thought that Bartolomé had not commented on the greatest literary scandal of that time: the Soledades. However, a more careful analysis of his texts highlights how Argensola fiercely criticized Gongora’s poem, even stating—although in Horatian mode—that poetry had become a monster, referring precisely to the verses in which Góngora offers one of the best proves of his genius: the dedication to the Duke of Béjar.
Trabajo social en la dictadura
Authors: Ramírez Marchant Constanza
Published: May 2021

El trabajo social como disciplina y espacio de resistencia histórica guarda un análisis político y social desde su formación y rápido desarrollo. La dictadura militar instaurada por Augusto Pinochet en Chile, encarnó un recorrido de represión, tortura y clandestinidad para la disciplina, por lo que fue necesario generar nuevas esferas de intervención profesional, lejos de la mirada asesina del gobierno de facto. Los movimientos feministas de la época y el rol de las trabajadoras sociales, se convirtieron en ejes claves para organizar a la comunidad y resistir ante el estado de terror generado por el gobierno de facto. Además de visualizar dicha trinchera de lucha, la disciplina logró construir procesos de resistencia que hoy mantienen en su identidad profesional.
Historia del ensayo y la literatura antiimperialista en Nicaragua: un acercamiento a los conceptos de soberanía y antiimperialismo desde la memoria ensayística y literaria
Authors: Narváez Fidel Ernesto
Published: May 2021

La historia geopolítica de Centroamérica, y en particular la de Nicaragua, ha estado transida por la cuestión del imperialismo. Su posición geográfica canalera, similar a la de Panamá, ha procurado que los grandes eventos históricos del país tales como la resistencia indígena, la independencia, la Guerra Nacional, la intervención yanqui y la Revolución Popular Sandinista, sean eventos con un marcado carácter antiimperialista y de defensa de la soberanía que en la memoria literaria y ensayística no han pasado desapercibidos. Este artículo pretende demostrar que tanto el ensayo como la literatura antiimperialista en Nicaragua componen un corpus de memoria histórica bastante amplio que es susceptible de ser conceptualizado y analizado como un movimiento o tendencia propia dentro de las expresiones literarias y ensayísticas de este país centroamericano.
ON THE ESSENTIAL SPECTRA OF GENERAL DIFFERENTIAL OPERATORS
Authors: IBRAHIM SOBHY EL-SAYED
Published: May 2021

In this paper, it is shown in the cases of one and two singular end-points and when all solutions of the equation $M[u]-\lambda uw=0$, and its adjoint $M^+[v] -\lambda wv = 0$ are in $L_w^2 (a, b)$ (the limit circle case) with $f\in L^2_w(a,b)$ for $M[u]-\lambda wu=wf$ that all well-posed extensions of the minimal operator $T_0(M)$ generated by a general ordinary quasi-differential expression $M$ of $n$-th order with complex coefficients have resolvents which are Hilbert-Schmidt integral operators and consequently have a wholly discrete spectrum. This implies that all the regularly slovable operators have all the standard essential spectra to be empty. These results extend those of formally symmetric expression $M$ studied in [1] and [12], and also extend those proved in [8] in the case of one singular end-point of the interval [a,b).
Kasper Cichocki (1545–1616) — A Catholic polemicist from Tarnów
Authors: Smoła Marek
Published: May 2021

The article constitutes a biography of a religious writer, born in Tarnów, educated at the universities in Cracow, Italy and Germany, a scholar and clergyman. He attained certain ecclesiastical dignities (the canon of Wilno and Sandomierz, the parson of three parishes), however, first and foremost, he achieved fame and recognition as the writer of two Latin texts. Both texts were created in defence of the Jesuit Order, at that time greatly attacked because of their uncompromising nature in fighting against the Protestants residing in Poland. In particular, the second text of Kasper Cichocki, “Alloquiorum Osieciensium”, became widely known in Poland as well as in Europe. Due to the fact that the text targeted the then reigning king of England and Scotland, James I Stuart, it met with acute diplomatic opposition from the court of London, who demanded a severe punishment for the author and a public burning of his work.
CHARMED BY THE KARKONOSZE MOUNTAINS: PRZEMYSŁAW WIATER (1958–2020)
Authors: Danielska Bożena
Published: May 2021

Przemysław Wiater PhD was a historian, art historian, museum curator, and a regionalist. In 1994–2020, he worked as a certified curator at the Carl and Gerhart Hauptmann House in Szklarska Poręba. In February 2020, he became Director of the Karkonosze Museum in Jelenia Góra. Furthermore, in 2008–2017, he ran courses at the Higher School of Management in Legnica. Committed to recovering historic monuments from Lower Silesia, he also served as a councillor for several terms of office in Szklarska Poręba, where he lived. An outstanding regionalist, Wiater focused on investigating the history of Lower Silesia, particularly the Karkonosze and Izera Mountains. He was the first to undertake research into the local tangible and non-tangible cultural heritage, popularizing it in publications describing the history of Szklarska Poręba, Walloon mineral and gem prospectors, old herbalists and laborants, history of glassworks, or the figure and legend of the Spirit of the Mountains. Having discovered the phenomenon of artistic colonies, he popularized it and adapted to harmonize with contemporary times. His idea was to culturally integrate the region basing on historical cultural contents and the heritage imported by post- -WW II settlers. Sharing his knowledge in a popular way, he infected others with his passion, particularly young people to whom he provided support and inspiration. It was at his instigation that the W.E. Peuckert Guild of the Sudety Mountains Guides was formed; member of the Chapter of the Sudety Mountains Walloon Brotherhood, he was also the knight of the informal Society of the Evening Castle, additionally cooperating with the Izery Society. Originator of the Izery Retro Run and the Flannel Rally, he inspired the formation of several tourist routes, such as the ‘Juliusz Naumonowicz Walloon Hiking Trail’, contributing to the creation of the ‘W.E. Peuckert Trail’ and the Polish-Czech ‘Laborants’ Trail’.
Bilateral relations between the Republic of India and the Republic of Serbia
Authors: Marić Vladimir
Published: May 2021

The text outlines and analyses the relations between India and Serbia from the formal establishment of diplomatic relations in 1948 till the present. The author gives special attention to the political and economic relations between the two countries. In the context of political relations, the author discusses the meetings that took place at the highest level as well as the significance of the Non-Aligned movement. With regard to economic relations, the paper points to the importance of bilateral cooperation that has developed since the establishment of diplomatic relations and has intensified in the past few years, with concrete results being achieved.
Strengthening the historical ties between Serbia and Cyprus in view of 21st century challenges and opportunities in Europe: The elevated geostrategic position in the Balkans and Eastern Mediterranean, the common legacy of neutrality and future engagement
Authors: Teofilaktu Dimitrios
Published: May 2021

The foundations of the strong historical ties between Serbia and Cyprus lie on common struggles, dating back to the 19th and 20th centuries, particularly during the two great wars. Their long struggles against various aggressors, like the Ottoman Turks, Nazi Germany and British colonialism, have left long-lasting wounds on their societies, but also a legacy of bravery, resilience, perseverance and national pride. The deep friendship is also premised on common cultural and Orthodox roots, which helped the two peoples overcome major challenges and preserve their national identity and cultural values. This analysis explores the challenges ahead and assesses the new strategic partnership, including the trilateral cooperation between Serbia-Greece-Cyprus, particularly in light of EU enlargement in the Western Balkans and the volatile situation in the Eastern Mediterranean. The article also attempts to evaluate how the policy of neutrality, that both Yugoslavia and Cyprus have pursued as founding members of the Non-Aligned Movement, would serve today the national interests of Serbia and Cyprus and, by extension, stability and security in their respective regions and the European continent at large, given their elevated geostrategic position.