bluuebunny/crossref_metadata_2025 huggingface dataset:
Possibility of HIV-1 Protease Inhibitors-Clinical Trial Drugs as Repurposed Drugs for SARSCoV-2 Main Protease: A Molecular Docking, Molecular Dynamics and Binding Free Energy Simulation Study
Authors: Iruthayaraj Ancy , Magudeeswaran Sivanandam , Poomani Kumaradhas
Published: April 2020

Initially, the SARS-CoV-2 virus was emerged from Wuhan, China and rapidly spreading across the world and urges the scientific community to develop antiviral therapeutic agents. Among several strategies, drug repurposing will help to react immediately to overcome COVID-19 pandemic. In the present study, we have chosen two clinical trial drugs TMB607 and TMC310911 are the inhibitors of HIV-1 protease to use as the inhibitors of SARS-CoV-2 main protease (Mpro) enzyme. To make use of these two inhibitors as the repurposed drugs for COVID-19, it is essential to know the molecular basis of binding mechanism of these two molecules with the SARS-CoV-2 main protease (Mpro). Understand the binding mechanism; we performed the molecular docking, molecular dynamics (MD) simulations and binding free energy calculations against the SARS-CoV-2 Mpro. The docking results indicate that both molecules form intermolecular interactions with the active site amino acids of Mpro enzyme. However, during the MD simulations, TMB607 forms strong interactions with the key amino acids of Mpro and remains intact. The RMSD and RMSF values of both complexes were stable throughout the MD simulations. The MM-GBSA binding free energy values of both complexes are -43.7 and -34.9 kcal/mol, respectively. This in silico study proves that the TMB607 molecule binds strongly with the SARS-CoV-2 Mpro enzyme and it is suitable for the drug repurposing of COVID-19 and further drug designing.
Editorial
Authors: Parayre Catherine
Published: April 2020

Editorial, Voix plurielles 17.1 (2020)
Ferland, Charles-Etienne. Une dent contre l’ordinaire
Authors: Parayre Catherine
Published: April 2020

Compte rendu, Ferland, Charles-Etienne. Une dent contre l’ordinaire
Enzymatic hydrolysis as an approach to produce alternative protein from cephalopods ink powder: a short review
Authors: Z. Ayu Shazwani , M.S. Rabeta
Published: April 2020

Cephalopoda is a class of Mollusca that lives in marine environments, well-known as the
most distinctive features of their ink especially squid and cuttlefish species. The various
valuable constituents in their ink have been used over millennia for practical and
commercial purposes. The current world population of 7.6 billion is expected to reach 8.6
billion in 2030, 9.8 billion in 2050, and 11.2 billion in 2100. Thus, the amount of food,
types of food in demand, and their relative contribution to diets will all change. We may
face a reduction in protein sources worldwide. Humans need protein in their daily diet to
maintain good health. To date, information on the benefits of squid and cuttlefish ink
hydrolysates in Malaysia as an alternative protein is lacking. This study aims to review
this gap and propose the potential of squid and cuttlefish ink hydrolysates as an alternative
protein.
EFEKTIVITAS MODEL PEMBELAJARAN KOOPERATIFTIPE TWO STAY-TWO STRAY DENGAN NUMBERED HEADS TOGETHER TERHADAP KEMAMPUAN BERPIKIR KRITIS MATEMATIKA SISWA
Authors: Denensi Fransiska , Gunur Bedilius , Jehadus Emilianus
Published: April 2020

Penelitian ini bertujuan untuk mengetahui: 1) efektifitas model pembelajaran kooperatif tipe Two Stay Two Stray (TSTS) terhadap kemampuan berpikir kritis matematika siswa, 2) efektifitas model pembelajaran kooperatif tipe Numbered Heads Together (NHT) terhadap kemampuan berpikir kritis matematika siswa, 3) membandingkan efektifitas penggunaan model pembelajaran kooperatif tipe Two Stay Two Stray (TSTS) dengan Numbered Heads Together (NHT) terhadap kemampuan berpikir kritis matematika siswa. Penelitian ini melibatkan siswa kelas VIII SMP Swasta Widya Bhakti Ruteng yang berjumlah 116 orang.  Pengambilan sampel menggunakan teknik random sampling, dengan terlebih dahulu dilakukan uji kesetaraan kelas. Hasil penelitian ini menunjukan, 1) model pembelajaran kooperatif tipe Two Stay Two Stray (TSTS) efektif terhadap kemampuan berpikir kritis matematika siswa; 2)  model pembelajaran kooperatif tipe Numbered Heads Together (NHT) efektif terhadap kemampuan berpikir kritis matematika siswa; 3) model pembelajaran kooperatif tipe Two Stay Two Stray (TSTS) lebih efektif dibandingkan dengan Numbered Heads Together (NHT)  terhadap kemampuan berpikir kritis matematika siswa.
2 : expérimenter l’hypermédia dans la bande dessinée numérique
Authors: Molina Fernández Margarita
Published: April 2020

Cet article tente d’explorer les rapports entre narration, interactivité et représentation visuelle dans la bande dessinée numérique. L’article vise à dévoiler la relation d’interdépendance établie entre l’interactivité et la narration, qui se manifeste dans le design narratif ; les possibilités de matérialisation des mécaniques interactives dans le design d’interface ; et enfin les stratégies d’intégration des ressources propres à d’autres médias au système de la bande dessinée. L’argumentation se développe à partir de l’analyse de l’œuvre 2 (www.2-bd.fr), une bande dessinée hypermédiatique dont la création conduit mon projet doctoral de recherche-création. Les exemples traités montrent comment la narration et l’interaction travaillent conjointement pour susciter l’engagement, les relectures et le changement de la motivation des choix du lectacteur ; comment le design d’objets interactifs et à la fois narratifs soutient l’immersion et l’empathie ; et la compatibilité de l’image fixe et en mouvement avec le contrôle du rythme de lecture et l’unicité de l’expérience de lecture interactive.
Otantik Liderlik Davranışının ve Çevresel Dinamizmin İşletmelerin İç Girişimcilik Eğilimi Üzerine Etkisi
Authors: ATTAR Melis , ÇETİNKAYA Buket
Published: April 2020

Çalışmanın amacı Konya’da dört ve beş yıldızlı otellerde beyaz yakalı çalışanların otantik liderlik düzeylerinin ve çevresel dinamizmin iç girişimcilikleri üzerindeki rolünü belirlemek olmuştur. Yazında geçerliliği ve güvenilirliği analiz edilen 62 ifadeden oluşan ölçek kullanılmıştır. Çalışanların otantik liderlik algısını ölçmek amacıyla Walumbwa vd.(2008)’nin geliştirdiği ölçek; iç girişimcilik eğilimini ölçmek amacıyla Antoncic ve Hisrich (2001) tarafından geliştirilen ölçek; çevresel dinamizmi ölçmek amacıyla Achrol ve Stern (1988) tarafından geliştirilen ölçek kullanılmıştır. Detaylı literatür taraması sonucu geliştirilen hipotezler 143 çalışan üzerinde test edilmiş ve kabul edilmiştir. Değişkenler tanımlayıcı istatistiki analize tabi tutularak incelenmiş ve SPSS 24.0 istatistik paket programı kullanılarak gerekli analizler yapılmıştır. Araştırma hipotezlerini test edebilmek amacıyla basit doğrusal regresyon analizi yapılmıştır. Analiz sonucunda, otantik liderliğin, iç girişimciliği pozitif yönde etkilediği sonucuna ulaşılmıştır (F(1,141)= 147,942, p<.001). Ayrıca çevresel dinamizm, işletmelerin iç girişimcilik eğilimini pozitif yönde etkilemiştir (F(1,141)= 189,016, p<.001).
A new hope: introducing comprehensive sex education to a Christian secondary school in Uganda after repeal of parliamentary ban
Authors: Boozalis Jaclyn A , Nakibuule Margaret H , Realini Janet P , Rosenfeld Jason
Published: April 2020

Background

One quarter of Ugandan girls aged 15-19 years have become pregnant, and by age 50, one quarter of women report experiencing a sexually transmitted infection (STI). Adolescent pregnancies pose health challenges because teenage mothers are constrained in their future pursuit of education and have an increased likelihood of adverse pregnancy outcomes. Uganda lifted a parliamentary ban on sexual education beyond abstinence in May 2018. This study aimed to introduce and evaluate a comprehensive sex education curriculum to prevent pregnancies and sexually transmitted infections at a secondary school in Uganda.

Methods

Over three weeks in June 2018, our team implemented a comprehensive reproductive health education curriculum called ‘big decisions’ in a secondary school in Uganda. Hope Comprehensive High School is a Christian school in Masaka, Uganda with approximately 400 students. We trained 15 teachers and co-facilitated the curriculum with a pilot group of 30 students. We measured student demographics and knowledge/attitudes toward sex, relationships, STIs, and contraception before and after the program.

Results

There was a statistically significant improvement in student knowledge about pregnancy, contraceptives, and STIs. We also noted an increase in positive attitudes toward condom use.

Conclusions

Engaging the faculty and staff with an appropriate and fact-based curriculum was crucial to the success of the project. Myths on contraceptive education and condoms were significantly debunked within the pilot group. This project demonstrates the viability of a non-faith based sex education curriculum in a Christian Ugandan secondary school.
The Curious Case of a Missing Coeliac Trunk: A Case Report and Review of the Literature
Authors: Saricilar Erin Cihat , Heyworth Ashley Peter , Singla Animesh
Published: April 2020

Introduction

The anatomy of the coelic trunk is highly variable. An understanding of the variations is important in general and vascular surgery due to the implications of disruption and consequent visceral ischaemia.

Case Description

A case is described of a 69-year-old woman presenting with undifferentiable abdominal pain, eventually leading to a diagnosis of aortitis and uterine cancer. Computed tomography (CT) angiography revealed a unique coeliac trunk variation with the common hepatic artery (CHA) arising directly from the abdominal aorta, and a splenogastric trunk, a relatively rare variant.

Discussion

The clinical picture was unique, with the anatomical variant complicating case. There are several clinical consequences of these anomalies, but it is critical for operative surgeons to understand the normal anatomy as well as variants to reduce surgical risks. The literature describes various classification methodologies, which assist in approaches intraoperatively. Predominantly stenting, chemoembolisation and catheterisation based procedures require a rigid understanding of the various anomalies that can be encountered, even though this case (Morita Class III) only presents in 0.23% of cases. This is sufficiently often enough that it is important to bring to light variations in the anatomy of the coeliac trunk.
Integrating Cognitive Antecedents to UTAUT Model to Explain Adoption of Blockchain Technology Among Malaysian SMEs
Authors: Khazaei Hamed
Published: April 2020

Blockchain technology is gaining consideration more and more and will potentially revolutionize most of the industries. Bitcoin cryptocurrency which uses Blockchain platform, has even promoted this technology more. Blockchain is a decentralized source and encrypted database for storing transaction information. Instead of being dependent on a centralised mediator like bank, by using blockchain, parties can transfer fund promptly trough connected ledgers called blocks. Using this method transactions will significantly be more transparent for both parties. Consequently, transactions are performed based on the distributed trust among other blockchain users in the network. Blockchain will promote transparency in every industry, yet implementation of blockchain technology is still limited. This study focuses to study the possible factors affecting adoption of blockchain technology by focusing on literature review and using Unified Theory of Acceptance and Use of Technology as a theoretical basis.
Elämäkerrallista helskyttelyä.
Authors: Maijala Minna
Published: April 2020

Panu Rajala: Virvatuli: Eino Leinon elämä. Helsinki: WSOY, 2017, 596 s.
Moderneja yhteisöjä ja yksinäisyyttä
Authors: Kuortti Joel , Anna-Leena Anna-Leena
Published: April 2020

Uuden vuosikymmenen ensimmäisen Avaimen artikkelien aiheet nivoutuvat yhteisön ja yhteisöllisyyden sekä toisaalta yksinäisyyden teemoihin modernisoituvan kansakunnan ja kyläyhteisön sekä modernin kaupunkiympäristön konteksteissa. Avain on itse avoin yhteisö ja toivottaa tervetulleiksi erilaisia kirjoituksia kirjallisuudesta.
Genus Allium L. (Alliaceae) in Siberia
Authors: Sinitsyna Т. A.
Published: April 2020

The genus Allium in Siberia has been revised. The materials of LE, WIR, MW, ALTB, NSK, OSBU herbarium collections, information resources on the Internet, literature data on the flora of various regions of Russia and neighboring states, as well as materials personally gathered during collecting missions have been analyzed. As a result, it was established that 62 Allium species grow in Siberia, of which 11 are endemic. The synopsis presented in the article reflects the modern system of the genus Allium. The information provided for each species includes that on the initial description, ecological confinement and geographical distribution, as well as the most common synonyms. The geographical analysis of Siberian alliums revealed the largest representation of species (18) with the South Siberian type of distribution area, which confirms one of the points of view that distinguishes this territory as a special center of species diversity of the studied genus.
Manejo del cáncer colorrectal durante la pandemia por SARS-CoV-2
Authors: Pinilla-Morales Raúl Eduardo , Caycedo-Marulanda Antonio , Castro-Beltrán Jorge Mario , Fuentes-Sandoval María Alejandra
Published: April 2020

El virus SARS-CoV-2 (Severe Respiratory Acute Síndrome por Coronavirus-2) es un beta-coronavirus, que se transmite de persona a persona a través de aerosoles generados por tos o estornudos y por contacto directo con las manos contaminadas a través de las mucosas, causando principalmente compromiso respiratorio. Su origen se considera la ciudad de Wuhan en China y debido a su alta transmisibilidad se convirtió rápidamente en una pandemia, afectando de diferentes formas un gran porcentaje de la población, incluido el personal de la salud, con gran morbi-mortalidad. Esto ha llevado a tomar medidas estrictas con respecto a la disponibilidad del recurso sanitario para atender a la población afectada, así como a la prevención y el manejo de la contaminación de los pacientes no infectados que requieren seguir siendo atendidos por otro tipo de patologías, como es el caso de los pacientes oncológicos. 

En este trabajo pretendemos revisar el manejo de los pacientes con cáncer colorrectal a la luz de la pandemia, del momento ideal de ser llevados a cirugía, de las opciones del abordaje quirúrgico, de la pertinencia de la colonoscopia diagnóstica y terapéutica, así como de la importancia que reviste la experiencia del cirujano y la institución en el manejo multidisciplinario de la patología colorrectal y de la pandemia de COVID-19. Considerando que la literatura actual está basada en recomendaciones de expertos con bajo grado de evidencia, la intención es presentar algunas sugerencias motivadas en la experiencia de nuestras propias instituciones, guiadas por la literatura disponible y en constante evolución.
Respuesta temporal al ambiente lumínico y la sequía inducida en el regenerado de una masa mixta en el entorno mediterráneo
Authors: Pardos Mínguez Marta , Madrigal Guillermo , De Dios-García Javier , Gordo Javier , Calama Rafael
Published: April 2020

El trabajo se desarrolla en las masas mixtas de pino piñonero, sabina y encina de los páramos calizos de la Meseta Norte. Se estudia la supervivencia, crecimiento, respuesta fisiológica y reparto de biomasa de una plantación de las tres especies a lo largo de un gradiente lumínico y bajo condiciones de sequía inducida. Se establecieron 12 parcelas (45 m2), divididas en dos subparcelas, a su vez con 4 bloques, donde se plantaron 9 plantas (3 plantas por especie). Se fijaron 3 niveles de luz (HL: GSF~0.75: ML: GSF~0.45; LL: GSF~ 0.26); y dos niveles de disponibilidad hídrica (Co: condiciones ambientales naturales; y W-: reducción de precipitación del 30% mediante sistema de exclusión de precipitación). El ensayo duró desde diciembre 2011 hasta mayo 2015. Se evaluó la supervivencia en 19 ocasiones y se midió la fluorescencia a la clorofila 4 veces. En mayo 2015 se hizo cosecha final,  analizándose el reparto de biomasa y crecimiento. Las mayores tasas de mortalidad se registraron tras el primer verano, con  efecto negativo del tratamiento HL sobre la supervivencia de encina y pino, y poco efecto  de la exclusión. Bajo sombra, las tasas de supervivencia fueron mayores. La supervivencia estuvo íntimamente relacionada con su comportamiento fisiológico,  modificado por el ambiente lumínico y la época del año, pero no por la exclusión. Los resultados confirman la mejor capacidad adaptativa de la sabina y la encina en estas masas mixtas, aunque a largo plazo se reducirá la resiliencia de la encina, afectando a su capacidad rebrotadora.
Entresaca por bosquetes pequeños y corta a hecho en dos tiempos sobre repoblaciones de Pinus pinaster Ait.
Authors: De Frutos López Sergio , Fernández Ramírez Sergio , Barrero David , Martínez Guillermo , García-Plansencia Susana , Castilla Miguel Angel , Del Rio Miren , Ruiz-Peinado Ricardo , Roig-Gomez Sonia , Bravo-Fern´ández José Alfredo
Published: April 2020

La gran superficie ocupada en España por repoblaciones protectoras con edades cercanas al turno exige abordar urgentemente su regeneración. El temperamento de luz de Pinus pinaster Ait. obliga a aplicar cortas continuas, justificadas selvícolamente pero que provocan impacto paisajístico y riesgo de erosión. Buscando conseguir regeneración suficiente y diversificación estructural y específica pero minimizando riesgos, se han instalado dos dispositivos experimentales en repoblaciones de Pinus pinaster de 50-65 años de edad situadas en Arbancón (Guadalajara) y Fuencaliente (Ciudad Real), sobre los que otoño de 2017 se cortó a hecho por bosquetes circulares (entresaca por bosquetes) de tamaños reducidos; en Fuencaliente también se ejecutaron cortas a hecho en dos tiempos sobre grandes superficies. Un año después de las cortas, los primeros resultados muestran que en Arbancón se ha conseguido regeneración suficiente en bosquetes con diámetros iguales a 1,5 y 2,5 veces la altura dominante de la masa: densidades medias en otoño de alrededor de 4500 pies ha-1 uniformemente repartidas, supervivencia estival del 67 % y nueva regeneración otoñal, con valores significativamente superiores a los de las zonas sin tratar). En Fuencaliente (bosquetes con diámetros entre 2 y 3,5 la altura dominante), la inadecuada ejecución de las cortas mecanizadas provocó remoción y compactación excesivas en el suelo, a pesar de lo cual en el otoño siguiente se alcanzan densidades de regeneración medias de 1500 pies ha-1 (en bosquetes) y de 2300 pies ha -1 (cortas a hecho en dos tiempos). En ningún caso se han apreciado signos de erosión.
Pengenalan Perangkat Keras pada Komputer
Authors: parnesia Putri
Published: April 2020

Hardware atau dalam bahasa Indonesia disebut juga dengan nama perangkat keras komputer adalah salah satu komponen dari sebuah komputer yang sifat alatnya bisa dilihat dan diraba secara langsung atau yang berbentuk nyata, yang berfungsi untuk mendukung proses komputerisasi. Perangkat keras digunakan untuk mengerjakan fungsi-fungsi penyiapan data, pemasukan data, penghitungan, pengawasan perhitungan, penyimpanan, dan pengeluaran (presentasi atau peragaan) hasil. Berdasarkan fungsinya hardware atau perangkat keras komputer dibagi menjadi 5 bagian : Input Device, Process Device, Output Device, Storage Device, Peripheral Device.
Tugas Komputer APRIANI (0305193142)
Authors: Apriani
Published: April 2020

Perangkat keras didefinisikan sebagai komponen-komponen perangkat yang dapat ditangkap dengan indra peraba manusia. Perangkat keras komputer (computer hardware) adalah komponen-komponen fisik yang membentuk satu kesatuan sistem Personal Computer (PC). Biasanya perangkat- perangkat ini dirakit dan sebagian besar dimasukkan ke dalam sebuah casing komputer dan sebagian lain berada di luar casing.
When Religion Helps: Aspects of Healthy Religiosity
Authors: Chelladurai Joe
Published: April 2020

Research on religion has been increasing steadily over the recent decades. There are several academic journals and international and national organizations interested in the social scientific scope of religion. It is well known that religion has been a powerful influence for good and bad, and debates of this nature are likely to continue. As a bystander to such conversations, I am curious to learn why does religion have such an influence. Relatedly I wonder in what ways and in what conditions can religion be a positive and helpful aspect of people's lives. While previous research has focused on the correlates and the influence of religion on health outcomes, I aim to examine what type of religious observance is related with such outcomes. What religious beliefs are facilitative? which aspects of religion can be beneficial to people?, and relatedly, how does one practice religion in a healthy way? Finding some answers to these questions can have potential implications for religious and non-religious people, clergy, and for people who have high religious priorities.
Social Value in the Novel Hatta: Aku Datang Karena Sejarah by Sergius Sutanto as Teaching Materials in Teaching Literature in Schools
Authors: Sulaeman Agus , Goziyah  , Purawinangun Ira Anisa , Noermanzah
Published: April 2020

A good novel can teach the value of life and benefits to its readers. One novel that has a life value, especially social values, is the novel Hatta: Aku Datang karena Sejarah by Sergius Sutanto. For this reason, this study aims to describe the social values in Hatta: Aku Datang karena Sejarah by Sergius Sutanto. This research uses a qualitative approach with the content analysis research method. Data collection techniques using documentation techniques that are based on the novel Hatta: Aku Datang Karena Sejarah by Sergius Sutanto. Data analysis techniques with steps: define the unit of analysis, set categories, coding, interpretation, and conclusions. Test the validity of the data using member checks and expert validity. From the results of this study indicate that the social values in the novel Hatta: Aku Datang karena Sejarah by Sergius Sutanto in the form ofthe value of love, the value of responsibility, the value of harmony in life. The most dominant value of love is found especially about devotion, caring, family, please help, and loyalty. The results of this study are expected to be used as teaching material in schools, especially in strengthening the character of students in Indonesian subjects that contain material about novels so that the social values contained in this novel can be implemented in social life.
Pembelajaran Berbasis Saintifik dan Multikultural dalam Menghadapi Era Masyarakat Ekonomi Asean (MEA) 2015
Authors: Noermanzah
Published: April 2020

Penulisan makalah ini bertujuan memberikan pemahaman tentang pembelajaran berbasis saintifik dan multikultural dalam menghadapi era Masyarakat Ekonomi ASEAN (MEA) 2015. Metode penulisan menggunakan metode tinjauan pustaka. Teknik pengumpulan data menggunakan teknik dokumentasi yang bersumber dari beberapa data referensi, seperti buku dan internet. Sedangkan teknik analisis data dengan beberapa langkah, di antaranya: reduksi data, seleksi data, sintesis, interpretasi, dan kesimpulan. Hasil penulisan makalah yaitu pembelajaran berbasis saintifik dengan langkah-langkah: mengamati, menanya, mencoba, mengolah, menyajikan, menyimpulkan, dan mencipta. Sedangkan pembelajaran berbasis multikultural merupakan pembelajaran yang penerapan strategi dan konsep pendidikan berbasis pada pemanfaatan keragaman yang ada di masyarakat, khususnya yang ada pada siswa seperti keragaman etnis, budaya, bahasa, agama, status sosial, gender, kemampuan, umur, dan ras sehingga tumbuh rasa menghargai setiap perbedaan.
Protection from uncertainty in the exploration/exploitation trade-off
Authors: Walker Adrian Raymond , Navarro Danielle , Newell Ben R , Beesley Tom
Published: April 2020

The exploration/exploitation trade-off (EE trade-off) describes how, when faced with several competing alternatives, decision-makers must often choose between a known good alternative (exploitation) and one or more unknown but potentially more rewarding alternatives (exploration). Prevailing theory on how humans perform the EE trade-off states that uncertainty is a major motivator for exploration: the more uncertain the environment, the more exploration that will occur. The current paper examines whether exploratory behaviour in both choice and attention may be impacted differently depending on whether uncertainty is onset suddenly (unexpected uncertainty), or more slowly (expected uncertainty). It is shown that when uncertainty was expected, participants tended to explore less with their choices, but not their attention, than when it was unexpected. Crucially, the impact of this "protection from uncertainty" on exploration only occurred when participants had an opportunity to learn the structure of the task prior to experiencing uncertainty. This suggests that the interaction between uncertainty and exploration is more nuanced than simply more uncertainty leading to more exploration, and that attention and choice behaviour may index separate aspects of the EE trade-off.
Priors in a Bayesian Audit: How Integration of Existing Information into the Prior Distribution Can Improve Audit Transparency and Efficiency
Authors: Derks Koen , de swart jacques , van Batenburg Paul , Wagenmakers Eric-Jan , wetzels ruud
Published: April 2020

Auditors often have prior information about the auditee before starting the substantive testing phase. We show that applying Bayesian statistics in substantive testing allows for integration of this information into the statistical analysis through the prior distribution. For example, an auditor might have performed an audit last year, they might have information on certain controls in place, or they might have performed analytical procedures in an earlier stage of the audit. Incorporating this information directly in the statistical procedure enables auditors to tailor their sampling plan to the auditee, thereby increasing audit transparency and efficiency. However, defining a suitable prior distribution can be difficult because what constitutes a suitable prior depends on the specifics of the audit and the auditee. To help the auditor in constructing a prior distribution we introduce five methodologies, consider their pros and cons, and give examples of how to apply them in practice.
Cultural participation in digital environments: Goals and stakes for Quebec cultural policies
Authors: Casemajor Nathalie , Bellavance Guy , Sirois Guillaume
Published: April 2020

Digital environments have expanded the forms of cultural participation. This paper has two aims: first, to elucidate the changing definitions of cultural participation in relation to digital environments; second, to examine the ways in which cultural policies respond to the new digital conditions of cultural participation. Focusing on Quebec (Canada), this paper is based on a critical review of grey literature in the public policy. We identified three main goals pursued by Quebec cultural policies regarding digital participation: 1) to produce and promote national cultural content; 2) to promote cultural equity; 3) to foster digital equity. The analysis shows that these goals partially exceed the scope of cultural policies to intersect with economic, educational, and youth policies. We also argue that policy frameworks and funding programs in support of cultural policies tend to legitimize an overlap of the social, economic, and political dimensions of cultural participation.
Pengaruh kebijakan dividen, kebijakan leverage, keputusan investasi dan manajemen laba terhadap nilai perusahaan pertambangan yang terdaftar di BEI tahun 2015-2018
Authors: Nurhasanatang Siti , Taufik Taufeni , Azlina Nur
Published: April 2020

Penelitian ini bertujuan untuk mengetahui pengaruh kebijakan dividen, kebijakan leverage, keputusan investasi dan manajemen laba terhadap nilai perusahaan pertambangan yang terdaftar di BEI Tahun 2015-2018. Jumlah populasi sebanyak 41 perusahaan, sedangkan jumlah sampel dalam penelitian ini sebanyak 10 perusahaan dengan periode data selama 4 tahun, sehingga data yang akan disajikan menjadi 40 data. Penarikan sampel menggunakan metode purposive sampling sedangkan analisis data menggunakan regresi Linier Berganda. Hasil penelitian menyimpulkan bahwa variabel kebijakan dividen, kebijakan leverage, keputusan investasi dan manajemen laba berpengaruh terhadap nilai perusahaan, sedangkan berdasarkan hasil uji koefisien determinasi diperoleh nilai sebesar 75,1%. Hal ini menunjukkan bahwa secara keseluruhan variabel berpengaruh terhadap nilai perusahaan sebesar 75,1%, sedangkan sisanya sebesar 24,9% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.This research aims to the effect of dividend policy, leverage policy, investment decision, and earning management on value company of mining listed at Indonesia stock exchange in 2015-2018. The total population are 41 companies, while the sample size in this study is ten companies with a data period of 4 years so that the data will be presented as 40 data. Sampling uses a purposive sampling method, while data analysis uses Multiple Linear Regression. The results of the study concluded that the dividend policy variable, leverage policy, investment decisions and earnings management affect the value of the company, while based on the results of the coefficient of determination test obtained value of 75.1%. This shows that overall the variables affect the firm value of 75.1%, while the remaining 24.9% is influenced by other variables not examined in this research leverage.
Incidental findings on multimodel comparison, hypothesis testing error, and its solution
Authors: Lim Weng Marc , Mandrinos Symeon
Published: April 2020

This article sheds light on an incidental discovery of hypothesis testing error and its solution in a study that compared the multimodel effects of information and knowledge on career decisions. Using a sample of 500 second and third year undergraduates who were simple randomly recruited from 10 simple randomly selected universities, the study demonstrates how hypothesis testing error could occur when multimodel comparison of the effects of the same set of independent constructs (information and knowledge) on a different but related set of dependent constructs (career pursuit and rewarding career pursuit) is performed and how that error can be avoided through detailed scrutiny of the psychic distance between the dependent constructs. It is hoped that the insights herein will be useful for scholars to avoid and overcome the pitfall of hypothesis testing error arising from multimodel comparison involving a different but related set of dependent constructs.
Coil2Stack: Ein innovatives Verfahren zur formatflexiblen Batteriezellherstellung
Authors: Weinmann Hannes W. , Töpper Hans-Christoph , Fleischer Jürgen
Published: April 2020

Kurzfassung

Die wirtschaftliche Herstellung von Lithium-Ionen-Batteriezellen in verschiedenen Formaten und aus unterschiedlichen Materialien fordert flexible Anlagen für die Stapelbildung. Im Rahmen dieses Beitrags werden deren Prozesse, aktuell verfügbare Lösungen sowie Trends in der Materialentwicklung analysiert, um ein neuartiges Anlagenkonzept abzuleiten, welches den Forderungen nach Flexibilität bezüglich Zellformat und Material gerecht wird und bisher bestehende Defizite ausgleicht.
Flexibilisierung des Energiebedarfs während der Warmlauf-phase einer Hauptspindel
Authors: Brecher Christian , Strachkov Anton , Steinert Alexander , Neus Stephan
Published: April 2020

Kurzfassung

Die Fertigungsgenauigkeit bei der Fräsbearbeitung ist von einer Vielzahl von Einflussfaktoren abhängig. Einige der wichtigsten Faktoren sind thermo-elastische Effekte. Zur Reduktion des thermisch bedingten Geometriefehlers wird vor dem Produktionsbetrieb obligatorisch ein Warmlaufprogramm ausgeführt. Die Minimierung der Dauer des Warmlaufprogramms kann die Produktivität positiv beeinflussen. In diesem Beitrag wird eine Methodik zur Flexibilisierung des Energieverbrauchs einer Werkzeugmaschine während der Warmlaufphase durch eine Erweiterung des Kühlkreislaufs vorgestellt.
Urbane Mikrofabriken für die hybride Produktion
Authors: Hildebrandt Lennart , Moritz Manuel , Seidel Benedikt , Redlich Tobias , Wulfsberg Jens P.
Published: April 2020

Kurzfassung

Dezentrale, vernetzte und offene Mikrofabriken im urbanen Raum, die mit moderner digitaler Fertigungstechnologie ausgestattet sind und sowohl Akteure und Bedarfe der industriellen Wertschöpfung als auch der Maker-Bewegung adressieren (hybride Produktion), haben das Potenzial, gesellschaftliche Mehrwerte zu erzeugen (Partizipation an Wertschöpfung, Innovationsförderung) und aktuellen Herausforderungen zu begegnen (Nachhaltigkeit, MINT-Bildung). In diesem Beitrag werden hierfür eine Definition der hybriden Produktion und ein eigens entwickeltes Planungsvorgehen für urbane Mikrofabriken vorgestellt.
РОЗРОБКА ІНСТРУМЕНТАЛЬНОГО МЕТОДУ ДОСЛІДЖЕННЯ ФАКТУРИ ТКАНИНИ
Authors: Нода О. М.  , Закора О. В.  , Рязанова О. Ю.
Published: April 2020

Modern consumers attach increasing importance to tactile sensations and the general perception of the surface of fabrics, therefore, the study of the structure and properties of woven textures is an urgent task of textile production. In textile technologies, organoleptic research methods are used mainly, which give a subjective visual and tactile assessment of the surface of the tissues. Therefore, there was a need to develop an instrumental method for determining the texture of fabrics, which was implemented on the basis of the existing method for studying the texture of hard surfaces. It is based on the idea of creating a constant mode of illumination of the object of observation, which is a tissue sample. The proposed method is based on the use of a special optical device for determining the qualitative and quantitative characteristics of textures and is a viewing chamber containing a mechanism for changing the lighting mode and a mechanism for capturing tissue images. For an objective assessment of the state of the surface of the tissues, the invoice indicator is calculated − the invoice coefficient. The implementation of the developed method allows to increase the efficiency of the processes of design-design of fabrics, to predict the appearance of fabrics and to ensure compliance with the texture of the fabric of the model of the garment.
USE OF WOUND PROTECTOR FOR PREVENTION OF SURGICAL SITE INFECTION IN LAPAROSCOPIC CHOLECYSTECTOMY
Authors: Vadim V. Kryzhevskii  , Mykola A. Mendel  , Anna P. Brodskaya  , Yulia V. Pavlovych
Published: April 2020

The work is based on the experience of 759 cholecystectomies performed in 2015-2018. Patients with a 3-4 grades of microbial contamination of wounds were divided into two groups: the first, with removal of the gallbladder traditionally with specimen retrieval container and the second, where proposed method of combined use of container and wound protector was used − 19 patients.Surgical site infection in laparoscopic cholecystectomy was detected in 5.40% (41 patients out of 759). During surgical interventions related to the second grade of microbial contamination (clean-contaminated), the frequency of SSI was 2.50%, to the third grade (contaminated) − 11.76%, and to the fourth grade (dirty) − 34.92%. Using the proposed method for the simultaneous use of the retrieval container and the double-ring wound protector in the second and third grades of wounds in LC allowed to reduce the frequency of SSI from 37.70% to 5.26%.
PROBLEMS RELATED TO PEDAGOGICAL SUPPORT SYSTEM OF CHILDREN WITH HEARING IMPAIRMENT OR DISORDERS IN REPUBLIC OF ARMENIA
Authors: Babayan L. A.  , Manukyan N. N.
Published: April 2020

In this article distinctive features related to the characteristic of children with hearing disorders due to story perception, teachers’ awareness level of research results related to mentioned problems, and some cultivated and justified approaches are presented. All researches are implemented in Republic of Armenian Tigranyan No 14 special school.
STIMULATION OF STUDENTS’ COGNITIVE ACTIVITIES IN THE PROCESS OF FOREIGN LANGUAGE LEARNING
Authors: Hadaichuk Nataliia  , Herasymenko Nadiia  , Melnyk Olesia  , Nykyporets Svitlana  , Slobodianiuk Alla
Published: April 2020

Currently the stimulation of students’ cognitive activity in learning a foreign language is one of the most pressing problems of pedagogy. In organizing the educational process of a foreign language, the motivation of students plays a significant role. Successful student motivation helps to set priorities, activate and concentrate thinking, increase interest in learning a foreign language as a whole and perform specific tasks in particular. The article considers the most relevant and actual methods of stimulating students’ cognitive activity in the modern technical non- linguistic university, aimed at modern youth, their interests and hobbies. The most expedient methods of activating students' educational activities have been mentioned.
FORMATION OF COMMUNICATIVE AND SPEAKING COMPETENCE OF SOCIAL WORKERS IN THE PROCESS OF PROFESSIONAL TRAINING
Authors: Liudmyla Berezovska
Published: April 2020

The article analyses the levels of communication skills of future social workers at the final stage of the research. It is stated that implementation of communication and speaking training is conditioned by the necessity of forming a competent specialist who has deep theoretical knowledge, communication skills necessary for establishing constructive interpersonal interaction and providing assistance to different groups of clients, and operates innovative technologies methods of assistance. It is possible to achieve a high level of professional competence during training, through a specially organized educational process aimed at the development of professional, communication and speaking skills that form the basis of future work of a social worker. The results of the study showed positive changes in the students of the experimental group, which made it possible to conclude on the efficiency of the proposed experimental method of forming the communicative and speaking competence of future social workers in the process of professional training.
Microsurgery in the Sickle Cell Trait Population: Is It Actually Safe?
Authors: Alperovich Michael , Park Eric , Alperovich Michael , Allam Omar , Abraham Paul
Published: April 2020

Although sickle cell disease has long been viewed as a contraindication to free flap transfer, little data exist
evaluating complications of microsurgical procedures in the sickle cell trait patient. Reported is the case of
a 55-year-old woman with sickle cell trait who underwent a deep inferior epigastric perforator (DIEP)
microvascular free flap following mastectomy. The flap developed signs of venous congestion on postoperative day two but was found to have patent arterial and venous anastomoses upon exploration in the
operating room. On near-infrared indocyanine green angiography, poor vascular flow was noted despite
patent anastomoses and strong cutaneous arterial Doppler signals. Intrinsic microvascular compromise or
sickling remains a risk in the sickle cell trait population as it does for the sickle cell disease population. Just
like in sickle cell disease patients, special care should be taken to optimize anticoagulation and minimize
ischemia-induced sickling for patients with sickle cell trait undergoing microsurgery.
Sleep Disorders and Dual Masculine Desires in Charles Dickens's “Lying Awake” and “Night Walks”
Authors: Lewis Daniel
Published: April 2020

Charles Dickens's examinations of sleep, dreaming, and sleep disorders illustrate a complicated negotiation between hegemonic ideals of masculinity that rest on notions of bodily control and mental acuity, but they also present an ambivalent (and sometimes adventurous) position open to expanding the definition of masculinity to include a desire to relinquish mental and physical control. Hegemonic masculine ideals are often in tension with one another, and Dickens explores the specific control–freedom contradiction in personal essays, namely “Night Walks” and “Lying Awake.” While the depiction of the bedroom as a space of male anxiety appears throughout Dickens's work, he expresses this idea most clearly and directly in the above nonfiction texts. The nonfiction essay, over and against the fictional text, allows Dickens to write about sleep disorders and their relation to male anxiety in more personal and pragmatic terms, and to represent the issue in detail without having to be concerned about plot and characterization.
The Oceanic Silence of Rebecca Horn
Authors: Halstead India
Published: April 2020

In this article, I reconsider the early work of artist Rebecca Horn as situated at the threshold of complex new theoretical, political, and artistic movements. Horn's performance pieces of the late 1960s and early 1970s formally echo this social upheaval, vibrating with tension between intimacy and isolation, pleasure and pain, human and machine. Horn's prosthetic sculptures gesture toward a continuity between body and world reminiscent of the Radical Freudian concept of Eros, echoed in the body art and sexual liberation movements of the 1960s, in which the body becomes a fluid expression of polymorphous, nonbinary desire. The sinister backdrop of postwar Germany, however, haunts the artist's work to the extent that silence becomes a motif of its own. Through her work, I ask the question: can the oceanic vision of a genderless Eros be realized, while the wounds of atrocity and of patriarchy are still inscribed on the body, or must polymorphous fluidity remain a fantasy, a utopia deferred?
Minority Report
Authors: Jones II Darryl L.
Published: April 2020

Black men are an integral part of the American pornographic industry, but their participation requires confronting and navigating a variety of simplified categorizations and assumptions that favor their sexuality over their humanity. Utilizing interviews with twelve prominent heterosexual black male figures (also known as “talent”) currently active in the industry, this article seeks to offer insight into the realities that the men face while participating in an industry viewed as taboo by mainstream society. Among the issues explored are their reasons for joining the industry, interracialism and racism, and moral and ethical dilemmas. Also employed are Lewis Gordon's concept of “epistemic closure,” or the cessation of inquiry, and Frantz Fanon's concept of the “phobogenic object,” or “stimulus to anxiety.”
Factores de riesgo de violencia a la mujer de parte del cónyuge
Authors: Arias Eugenia Fabián , Vilcas Baldeón Luz María , Alberto Bueno Yovana
Published: April 2020

El objetivo del presente trabajo fue realizar una revisión bibliográfica sobre los factores de riesgo de la violencia a la mujer por parte de su cónyuge, considerando que factores de riesgo son característicos o circunstancia que tienen la probabilidad de desarrollar algún efecto y/o consecuencias adversas. Se analizan las investigaciones que se han realizado sobre los factores de riesgo, los resultados de esta revisión permiten concluir que la violencia a la mujer es histórica ha permanecido y aún permanece en gran porcentaje oculta, porque la mayoría no denuncia por temor a sufrir más violencia. Los factores de riesgo para que ocurra la violencia contra la mujer es multifactorial por las características de la dinámica familiar de cada país. Los resultados de los estudios evidencian que los factores de riesgo de la violencia a la mujer se encuentran en el nivel macro estructural; exosistema, y microsistema. Además, se tiene diversas teorías y modelos que explican los factores que están asociados a la violencia contra la mujer.
Intelligent infusion controller with a physiological information feedback function
Authors: Li Jing , Dong Pengfei , Lai Yongxin , Qin Xiansheng , Bai Jing , Wang Hongbo , Wan Zhanxi , Ji Zhenyu , Shi Xuetao
Published: April 2020

BACKGROUND:

In hospitals, some problems still exist, such as transfusion reaction that cannot be dealt with in time, medical staff cannot observe the physiological information of the infusion patients in real time, and the infusion speed cannot be controlled smartly.

OBJECTIVE:

To address these problems, we propose a method for intelligent monitoring and designed a controller for dripping speed regulation.

METHODS:

A photoelectric sensor was used to obtain the heart rate (HR) information, and a PID parameter self-tuning controller based on the fuzzy control principle was developed to establish a multi-stage adaptive control method based on HR feedback. By controlling the rotation of the motor to drive the cam to control the drip rate smartly. Also, the infusion and physiological information are transmitted to the nurse station to monitor the possible transfusion reaction.

RESULTS:

The experiments show that the intelligent infusion controller can achieve HR signal detection with an average accuracy of over 94%, dripping speed detection and adjustment with an average accuracy of above 98% and adjustment time within 35 seconds.

CONCLUSION:

Our study proved that the intelligent infusion controller can control the infusion process intelligently and effectively, and has excellent reliability, small steady-state error and high practical value.
TLD environmental monitoring of new scanner facilities at the Nuclear Medicine Department of the Taiwan Medical University Hospital
Authors: Le Yingyi , Weng Jui-Hung , Lee Tsung-Min , Lee Yueh-Chun , Kao Pan-Fu , Pan Lung-Kwang , Chen Chien-Yi
Published: April 2020

OBJECTIVE:

Single-photon emission computed tomography (SPECT) as well as dual energy X-ray absorptiometry (DXA) scanners were designed in July 2018 at the Nuclear Medicine Department (NM), of the Taiwan Medical University Hospital. These scanners emit substantial X-rays from the target, which are tungsten, iron. Therefore, patients undergoing SPECT and DXA diagnosis, in addition to medical personnel, are exposed to undesirable photon leakage.

METHODS:

Following administration of radiopharmaceuticals, patients become radioactive sources; thus, it is necessary to evaluate a possible increase in the environmental gamma exposure rates in the NM as a result of the operation of the new scanners. A three month evaluation of environmental radiation in the NM was performed using the accurate and sensitive TLD-100H approach, which gives an error rate less than 10%.

RESULTS:

Detected exposure radiation rates in the NM ranged from 0.12 [Formula: see text] 0.02 to 1.00 [Formula: see text] 0.15 mSv per month, indicating that the imaging room had significantly different radiation rates. The results were compared with previous results, and no significant contribution to the enhancement of environmental gamma radiation was detected, which remained far below the occupational dose recommended by ICRP 60. The minimum detectable dose (MDD) for environmental radiation is also discussed herein to demonstrate the reliability of TLD-100H.

CONCLUSION:

Recommendations were sent to the authorities of AEC-ROC to implement actions that could reduce doses at these high-dose locations to meet the ALARA principle.