bluuebunny/crossref_metadata_2025 huggingface dataset:
Rezyliencja ekonomiczna i model biznesu przedsiębiorstwa logistycznego
Authors: Banaszyk Piotr
Published: June 2022

In 2020, many pressures have accumulated affecting the real economy and the existing economic theories describing and explaining them. These pressures include the global economic crisis, natural and climate disaster, political tensions and the COVID-19 pandemic, which are mutually reinforcing and represent a temporal turning point in the practice and theory of economics and management. The shock of 2020 also undoubtedly concerns the principles and methods of managing a logistics company. The study analyses and critically evaluates the current method of evaluating the efficiency of logistics company management and the business model corresponding to this method. The economic, social and natural consequences of the hitherto economic activity of logistics companies were indicated. In order to overcome the identified negative effects of their activities, new evaluation criteria and a new business model were proposed. It is postulated that the so-called economic resilience (RE), which consists of a set of specific criteria related to economic productivity, safety and agility. Economic productivity ensures the financial profitability of business activity, safety refers to sanitary and social guarantees, and agility to effective market adjustments. The proposed business model should be composed of three key mechanisms – sectoral, innovative and cultural. The sectoral mechanism is created by the driving forces of competition, the innovative mechanism - striving to improve the existing facts, and the cultural mechanism – the applicable ethical and moral standards.
Logistyka ostatniej mili jako najdroższy odcinek łańcucha dostaw
Authors: Boichuk Nataliia
Published: June 2022

Last mile logistics is considered the most expensive part of the supply chain. This is due to the high cost of deliveries related to the costs of organizing the transport of small parcels to individual customers, including the costs of fuel, vehicle operation and couriers. Considering the growing popularity of e-commerce among citizens, the growing problem of the last mile of deliveries should be analysed. The study focuses on the analysis of the literature on the subject, as well as on the existing or possible solutions to issues related to deliveries to the end customer. The main aim of the study is to present the proposed solutions to the last mile problem in the light of possible benefits for the development and improvement of urban logistics and the associated negative aspects. The indirect goal is to present solutions in Poland regarding the last section of the supply chain.
Valoración de inversiones mediante juegos de opciones reales
Authors: Moreno Arias Juan Marcos
Published: June 2022

En el presente artículo se valora un proyecto de inversión a través de la Teoría de Juegos de Opciones Reales (ROG, por sus siglas en inglés), este enfoque permite ampliar el análisis estándar de valoración al incorporar escenarios de flexibilidad e incertidumbre en estructuras de mercado como monopolio y oligopolio. Dada la importancia que tiene la toma de decisiones en los proyectos de inversión, nace la necesidad de poder identificar estrategias con herramientas que permitan superar las limitaciones de los métodos tradicionales basados en el modelo de flujo de caja descontado (FCD), analizando los impactos que puedan existir sobre la inversión al incorporar las acciones de los demás participantes del mercado.
Optimización robusta de portafolios: conjuntos de incertidumbre y contrapartes robustas
Authors: Zapata Quimbayo Carlos Andrés
Published: June 2022

Los modelos de optimización robusta (OR) han permitido superar las limitaciones del modelo media-varianza (MV), que comprende el enfoque tradicional para la selección de portafolios óptimos de inversión, al incorporar la incertidumbre de los parámetros del modelo (retornos esperados y covarianzas). En este trabajo se presentan los desarrollos de la OR en la teoría de portafolio mediante el enfoque del peor de los casos, a partir del cual se incorporan las formulaciones robustas para el modelo MV, teniendo en cuenta los trabajos de Markowitz y Sharpe. A partir de estas formulaciones, se lleva a cabo una sencilla aplicación en la que se resaltan las ventajas y bondades de las contrapartes robustas frente al modelo MV original. Al final, se presenta una breve discusión de formulaciones adicionales en materia de conjuntos de incertidumbre y otras medidas de desempeño.
Investigation of the relationship between contrast nephropathy development and body mass index in patients receiving contrast media in the emergency department
Authors: DİLEK Mehmet Seyit Şerif , İŞLER Yeşim , KAYA Halil , YÜKSEL Melih
Published: June 2022

Objectives: This study aims to investigate the risk factors in patients presenting to the emergency department, undergoing contrast-enhanced computed tomography (CT), and developing contrast-induced nephropathy (CIN) and whether there is a relationship between CIN and body mass index (BMI).
Methods: A total of 336 patients presenting to the emergency department between 15.3.2019 -31.12.2019 and underwent CT by administering intravenous (IV) contrast agent (CA) were prospectively analyzed. Patients' age, gender, chronic diseases, height, weight, BMI, and hospitalization or discharge information were recorded. Control creatinine was measured at 72nd and 120th hours. Patients who developed CIN were recorded.
Results: The mean age of the patients was 57 years (min: 18-max: 96) and 56.5% were male. CIN developed in 6.5% of the patients. Congestive heart failure (CHF) was associated with the increased risk of CIN (p = 0.045). There was a significant increase in CIN risk in patients aged 40-70 years (p = 0.008). The risk of CIN development was increased with advanced age (p = 0.002). Dialysis was required in 13% of patients who developed CIN. There was no significant relationship between BMI and CIN development (p = 0.740).
Conclusions: We did not find a significant relationship between BMI and CIN. However, the risk of CIN development was higher in patients over 40 and especially in patients with CHF.
ferramenta bow-tie no gerenciamento de riscos em projetos
Authors: De Souza Jeferson Tadeu , Souza João Artur
Published: June 2022

O processo de gestão de riscos é uma importante ferramenta para que se possa aumentar a probabilidade de sucesso em projetos. A ferramenta Bow-Tie é uma abordagem apontada pela ISO 31010:2012 para o auxílio no processo de avaliação de riscos. Este instrumento tem sido usado no setor industrial em várias partes do mundo, para a gestão de riscos em assuntos diversos, contudo se mostra assunto pouco explorado no Brasil. Dado a isso, o presente artigo pretende por meio de pesquisa bibliográfica sistemática buscar entender se a ferramenta é eficiente para a gestão de riscos em projetos. Constatou-se que, embora o estudo entre o PMBOK, a ISO 31000:2009 e a ISO 31010:2012 apontem para a viabilidade do seu uso, os textos acadêmicos não incipientes para uma conclusão mais precisa.
DATA-DRIVEN NA INDÚSTRIA DA MODA:
Authors: Paasch Marcio Rodolfo , Maximiliano Cristiani , Prado Vitória , Schneider Thaissa
Published: June 2022

O desenvolvimento de produtos representa um processo central na indústria da moda, é um conjunto de ações que conectam o mercado, tendências e o comportamento do consumidor com o ambiente industrial, que por sua natureza inovadora precisa ser constantemente aprimorado para aumentar a vantagem competitiva. Neste contexto, uma cultura orientada por dados deve ser promovida e compartilhada entre os vários atores e processos nas diferentes fases do produto. A utilização de uma pesquisa exploratória permitiu aos autores responder o objetivo de identificar como os profissionais da indústria de moda de Santa Catarina utilizam os dados no processo de criação de produto. Após uma análise da literatura existente foram identificadas ações e estratégias que envolvem a cultura data-driven na indústria da moda e posteriormente estas informações foram confrontadas com as respostas obtidas nos questionários aplicados aos profissionais da área de criação de moda. Ao final percebe-se uma predominância pela utilização de dados obtidos no processo de vendas, pouco explorado no que tange os conceitos do data-driven, criando assim uma oportunidade de melhoria quanto ao uso de dados para o processo de criação de produtos de moda.
PROSPECÇÃO DE FERRAMENTAS PARA GESTÃO DE PESQUISA E DESENVOLVIMENTO EM INSTITUIÇÕES DE CIÊNCIA E TECNOLOGIA
Authors: Nhoatto Fabiano , Justino Adrielson , Lopes de Souza Efren , Lobato Fábio Manoel França
Published: June 2022

A análise de grupos de pesquisadores e de suas respectivas produções são atividades relevantes e complexas. Na medida em que novos conhecimentos são gerados, é necessário que seja conduzida uma avaliação de todas essas produções, sobretudo quanto a qualidade e impacto. No Brasil, os pesquisadores alimentam a base de dados Lattes com todas as suas produções técnico-científicas pertinentes. Sendo à luz deste cenário, o presente estudo objetiva apresentar o cenário das principais ferramentas de extração e análise da Plataforma Lattes por meio da realização de uma prospecção tecnológica. E ainda, identificar como as Instituições de Ensino Superior publicizam a produção técnico-científica de seus pesquisadores. Este estudo é caracterizado como pesquisa exploratória, descritiva e de abordagem quanti-qualitativa. Os resultados mostram que nenhuma das ferramentas de extração analisadas atendeu todas as funcionalidades necessárias para avaliação cienciométrica de pesquisadores. Também, identificado que as Instituições de Ensino Superior, possuem maior tendência a organizar seus indicadores e divulgar dados em conjuntos de páginas estáticas. O estudo conclui sugerindo a necessidade de uma nova solução tecnológica, que atenda funcionalidades indispensáveis para o auxílio em tomadas de decisão na gestão de pesquisas, principalmente no que tange a visualização da informação de forma interativa.
ESTRATÉGIAS PARA A AQUISIÇÃO E A CRIAÇÃO DO CONHECIMENTO NA PERSPECTIVA DA ENGENHARIA DO CONHECIMENTO:
Authors: Cravo Ana Cristina , Aparecida Rauen De Luca Canto Cleunisse , Hahn de Lima Raquel , Cid Bastos Rogério
Published: June 2022

Objetivo: Identificar métodos e técnicas que podem ser observados na literaturapara a aquisição e a criação do conhecimento na perspectiva da engenharia doconhecimento. Método: Uma revisão de escopo foi realizada em cinco bases dedados. Os estudos incluídos foram os que apresentaram o constructo ‘knowledgecriation’ no título, abstract ou palavras-chave e que durante a leitura completapermitissem identificar métodos e técnicas auxiliares a criação do conhecimento,tendo como suporte a engenharia do conhecimento. Resultado: Vinte e cinco(25) estudos estão contemplados, sendo treze (13) dentro do espaço temporalde 2016 a 2020 e doze (12) de 2004 a 2015. As dimensões organizacionaisabrangidas são cultura organizacional, aprendizagem organizacional, cogniçãoorganizacional, processos e rotinas, capital intelectual e capacidade absortiva/inovação. Conclusão: Observou-se que a engenharia do conhecimento disponibilizadiferentes ferramentas tecnológicas como estratégia para a aquisição ea criação do conhecimento, dando suporte à gestão do conhecimento.
Models of Bounded Arithmetic Theories and Some Related Complexity Questions
Authors: Alam Abolfazl , Moniri Morteza
Published: June 2022

In this paper, we study bounded versions of some model-theoretic notions and results. We apply these results to the context of models of bounded arithmetic theories as well as some related complexity questions. As an example, we show that if the theory \(\rm S_2 ^1(PV)\) has bounded model companion then \(\rm NP=coNP\). We also study bounded versions of some other related notions such as Stone topology.
Tolerating Inconsistencies: A Study of Logic of Moral Conflicts
Authors: Mishra Meha , Sarma A.V. Ravishankar
Published: June 2022

Moral conflicts are the situations which emerge as a response to deal with conflicting obligations or duties. An interesting case arises when an agent thinks that two obligations A and B are equally important, but yet fails to choose one obligation over the other. Despite the fact that the systematic study and the resolution of moral conflicts finds prominence in our linguistic discourse, standard deontic logic when used to represent moral conflicts, implies the impossibility of moral conflicts. This presents a conundrum for appropriate logic to address these moral conflicts. We frequently believe that there is a close connection between tolerating inconsistencies and conflicting moral obligations. In paraconsistent logics, we tolerate inconsistencies by treating them to be both true and false. In this paper, we analyze Graham Priest’s paraconsistent logic LP, and extend our examination to the deontic extension of LP known as DLP. We illustrate our work, with a classic example from the famous Indian epic Mahabharata, where the protagonist Arjuna faces a moral conflict in the battlefield of Kurukshetra. The paper aims to avoid deontic explosion and allows to accommodate Arjuna’s moral conflict in paraconsistent deontic logics. Our analysis is expected to provide novel tools towards the logical representation of moral conflicts and to shed some light on the context-sensitive paraconsistent deontic logic.
Teachers' perceptions of the factors influencing rural school Grade 12 Business Studies learner performance in the National Senior Certificate
Authors: Mtshali Muntuwenkosi Abraham , Ngwenya Jabulisile Cynthia , Myende Thandanani Hansford
Published: June 2022

The purpose of this study is to examine teachers’ perceptions of teacher factors affecting the dwindling Grade 12 learners’ performance in Business Studies National Senior Certificate (NSC) examinations at the rural Umbumbulu circuit of Umlazi district, in the province of KwaZulu-Natal, South Africa. The study employed a qualitative research methodology to explore teachers’ perceptions. Five Grade 12 teachers were purposively selected from five rural secondary schools that offered Business Studies as a subject of teaching and learning in the Umbumbulu circuit. The case study research design was used to focus on a few participants who had lived experiences of teaching Business Studies at Grade 12 in rural schools and could relate to dominant factors influencing learner performance in this subject. Data were generated through faceto- face, semi-structured interviews, and thematic analysis was used as a method of analysing qualitative data with the purpose of identifying salient traits in data that could develop into themes. The study found that teacher factors influencing learner performance in Grade 12 Business Studies were teacher approaches to teaching Business Studies, timetabling and impediments to innovative teaching and assessment in the form of rural contextual factors such as large classes and a shortage of textbooks. The study nurtures awareness of teacher factors influencing rural school learners’ performance in Grade 12 Business Studies, so that Business Studies teachers in emerging economies can think of ways to address these factors to improve learner performance.
Adapting to technology tools in a learning environment: A case study of first-year students at a traditional African university
Authors: Olaitan Olutoyin , Mavuso Nosipho
Published: June 2022

The introduction of technology to teaching and learning has brought about modernisation of academic activities. The drastic paradigm shift faced by the education sector is inevitable, especially as the impact of the much-touted Fourth Industrial Revolution is being felt in key sectors of the economy. This reality imposes the need for technology-enhanced learning for tertiary students as it represents the future of the workplace for which they are being prepared at university. For effective learning to take place, institutions need to incorporate technological tools in their teaching and learning. Adapting to a myriad of technology tools can be challenging, especially for less privileged learners who might be adjusting to tertiary life and previously have not been exposed to the basics of computers and other technology tools. This challenge is further compounded by the fact that most of these learners are experiencing the independence of tertiary education for the first time and are still struggling to balance their academic workload with the anxieties of social blending. This paper investigated how first-year students at a traditional, previously disadvantaged university in the Eastern Cape province, South Africa, adapted to Blackboard Learn (also referred to as WiseUP), the learning management system (LMS) adapted for blended learning at the university. The paper explored the challenges faced by the new students and thereafter employed a combination of the Theory of Planned Behaviour and the Technology Acceptance Model to build a new model, which reveals the critical factors that influence students to embrace technology. This model will assist lecturers, faculty and student support structures to understand the underpinning factors that influence first-year students to embrace the technology tool, namely, the university’s LMS. Quantitative data collection and analysis were used in the case study, which was conducted with two groups of first-year students in management and information technology courses. Results show the significant factors that influence students’ attitudes positively towards the use of technology for learning.
Estudio de la productividad y biomasa arriba del suelo, mediante el uso de índices de vegetación en plantaciones de Tectona grandis L. (Teca) ubicadas en Guanacaste, Costa Rica
Authors: Porras Granados Arleth , Arias Aguilar Dagoberto , Soto Montoya Casia , Ríos Garro Vinicio
Published: June 2022

La estimación del volumen de la madera o de la biomasa en plantaciones forestales es una de las variables clave para la toma de decisiones del manejo forestal, para mejorar la productividad y la rentabilidad de los productos y servicios ambientales que ofrecen. Las técnicas tradicionales se han basado en inventarios de campo, mediante muestreo con parcelas y con intervención humana en la adquisición de variables a nivel de árbol y de rodal. La tecnología actual permite realizar estimaciones mediante sensores en vehículos autónomos y en satélites. En Costa Rica los estudios con imágenes satelitales Landsat y RapidEye han permitido generar mapas actualizados sobre cobertura y uso del suelo, incluyendo los tipos de bosques. Sin embargo, hay pocos estudios sobre la relación entre los valores de volumen y biomasa, calculados a partir de los datos medidos en campo y los calculados con percepción remota. Este artículo presenta la metodología propuesta, para estimar la productividad de plantaciones forestales de Tectona grandis L. (Teca) utilizando imágenes satelitales Sentinel-2, se tomó en cuenta las recomendaciones de otros autores y la experiencia de los investigadores. Se propone comparar la información generada con Sentinel-2 y la adquirida con un VANT con una cámara multiespectral. Se espera aportar una metodología que utilice sitios de muestreo representativos, con un tamaño de muestra adecuado, con un control de las condiciones ambientales, que tome en cuenta la edad, el estado fenológico y los tratamientos silviculturales.
Vivienda nómada: solución de vivienda móvil en Costa Rica para ambientes urbanos y rurales sostenibles
Authors: Solis-Mejia Isaac Jose , Ugalde-Hernández Carlos , Arias Aguilar Dagoberto
Published: June 2022

Este trabajo cita, sintetiza, puntualiza y describe información, elementos e interacciones que generan diferencias cuantitativas y cualitativas en cuanto al comportamiento del individuo y su vivienda enmarcado en el contexto de la evolución histórica de la especie humana y los distintos conceptos arquitectónicos bajo criterios de sostenibilidad. Es por medio del entendimiento del proceso histórico de la especie humana en el desarrollo, esfuerzo y mejoramiento de lo que significa la vivienda tradicional sedentaria lo que contribuye e inspira la gestión de nuevos procesos de investigación para definir y proponer un nuevo modelo de vivienda móvil contemporáneo, basado en el origen nómada de nuestra especie. Es por medio de la experiencia profesional, investigación y citación de documentación formal existente, que se propone una solución de vivienda móvil nómada que permita alivianar los ambientes urbanos y rurales contemporáneos, para acoplarnos a la norma del ordenamiento territorial existente de Costa Rica siendo diferentes al modelo tradicional sedentario.
Índices de calidad de agua en México y Colombia. Evolución, criterios y cambios
Authors: Gaytán-Alarcón Ana Patricia , González-Elizondo María del Socorro , Vergara Gómez Inés , Díaz Lagos Mercedes , Alarcón Herrera María Teresa
Published: June 2022

The Water Quality Index (WQI) is a simple and easy-to-understand tool for analyzing and reporting quality trends. Water quality is not static and depends on multiple factors, in this sense; globally various indices have been developed based on local water quality criteria. This paper explores and discusses about water quality assessment and their steps taking into account the widely used index models in the world. These steps include selecting the parameters, sub-index generation, weightings of the parameters, and sub-indices aggregation. The advantages and disadvantages of each index identified,and the main limitations that arise in the calculation of the different methodologies detected. These limitations are the subjectivity in selecting and weighing the parameters and the ambiguity and eclipsing in the aggregation stage. Objectivemethodological tools to solve these limitations consider the use of statistical and fuzzy logic techniques. The CCMEWQI is a versatile water quality index, since it allows the determination of the temporal and spatial conditions for the different uses in a specific way, achieving with regulations, and based on the analysis of monitoring data for each region.
NANOPARTÍCULAS DE ORO FUNCIONALIZADAS CON L-CISTEÍNA PARA DETECCIÓN DE ARSÉNICO EN AGUA
Authors: González Edgar E. , Acuña Yesid A. , Quiroz Ana M.
Published: June 2022

En este artículo se reportan resultados experimentales de interacciones del aminoácido L-cisteína (Cis) con nanopartículas de oro (AuNPs) y nanopartículas de oro funcionalizadas con Cis (AuNPs+Cis) cuando se incorpora en la solución iones de As3+. En los procesos de agregación se evalúa el papel de la concentración de la Cis en la funcionalización, además del tamaño de las nanopartículas cuando se incorpora a la solución el agente iónico de interés. Los resultados muestran una sensible dependencia en la agregación de las nanosondas AuNPs+Cis en función de su tamaño, con un registro de mayor sensibilidad para nanopartículas de mayor diámetro. Se observa que la concentración de la Cis en el proceso defuncionalización es condición necesaria para la programación de la estabilidad de las nanosondas, aspecto esencial paraconfigurar un modo estable para detección del agente iónico. De manera que, estos resultados permiten establecer criteriosútiles para el diseño de sensores colorimétricos para detección de metales pesados en aguas contaminadas.
Hepatit-B virüs ilişkili hepatosellüler karsinomda tümöral glipikan 3 mRNA seviyesinin diagnostik ve prognostik biyobelirteç olabilme potansiyelinin entegratif transkriptomik meta-analiz ve biyoinformatik ile değerlendirilmesi
Authors: ATAY Sevcan
Published: June 2022

Amaç: Bu çalışmanın amacı HBV-ilişkili hepatosellüler kansinom hastalarında tümöral GPC3 mRNA seviyesinin diagnostik ve prognostik biyobelirteç olabilme potansiyelinin değerlendirilmesidir. Gereç ve Yöntem: Eşlenik tümör içermeyen karaciğer dokularına göre HBV-ilişkili HCC tümör dokularında GPC3 mRNA ekspresyonu entegratif transkriptomik meta-analiz yöntemi ile belirlendi. Sonuçlar farklı bir hasta kohortunda valide edildi ve GPC3 mRNA seviyesi ile klinik değişkenler arasındaki ilişki değerlendirildi. Bulgular: Meta-analize 4 farklı veri setinden (GSE19665;GSE84402;GSE121248;GSE55092) HBV-ilişkili hepatosellüler karsinom dokuları (n=61) ile eşlenik tümör içermeyen dokulara (n=61) ait transkriptomik veriler dahil edildi. GPC3 mRNA seviyesi’nin eşlenik dokulara göre tümörde daha yüksek olduğu bulundu (kat değişimi=12,88; p=0; FDR=0). Sonuçlar GSE14520 veri setinde (HBV-ilişkili HCC tümör (n)=203;eşlenik non-tümöral doku (n)=203) valide edildi (log-kat değişimi= 4,82; adj.p=1, 43 E-79). ROC analizi sonucunda GPC3 mRNA seviyesinin tümör dokularını tümör içermeyen eşlenik karaciğer dokularından yüksek spesifite ve sensitivite ile ayırabildiği bulundu (n=203;AUC=0,9108;%95CI=0,08792-0,9424;p<0,0001). Tümöral GPC3 mRNA seviyesi ile hastalarda genel sağkalım (HR (logrank)= 0,81; %95CI=0,5223-1,2771; p= 0,3663), 3 yıl içinde rekürrans gelişimi (p=0.5793) ya da erken (<1 yıl) ve geç rekürrans (>3 yıl) (p= 0.9950) arasında bir ilişki bulunmadı. Çok-değişkenli Cox orantılı tehlikeler regresyon analizleri sonucunda da GPC3 mRNA seviyesi ile genel sağkalım arasında bir ilişki bulunmadı. Yüksek GPC3 mRNA seviyesi yüksek serum AFP seviyesi, küçük tümör boyutu ve aktif viral replikasyon ile ilişkili bulundu. GPC3 mRNA seviyesi CLIP evre 0’a göre evre 1’de daha yüksekti, fakat TNM ve BCLC evreleme arasında ilişki yoktu. Sonuç: Çalışma sonuçları HBV-ilişkili HCC ve yakın tümör içermeyen karaciğer doku ayrımında GPC3 mRNA seviyesinin yüksek spesifite ve sensitivite ile iş görebilecek bir diagnostik biyobelirteç olma potansiyelinin oldukça yüksek, fakat prognostik bir biyobelirteç olabilme potansiyelinin düşük olduğunu önermektedir.
Miyelodisplastik sendrom hastalığında P53 polimorfizmlerinin önemi
Authors: VATANSEVER Bahar , AYGÜNEŞ JAFARİ Duygu , GÜLER KARA Hale , SEVİNÇ Ege , KAYMAZ Burçin , ALP Gülay , ŞAHİN Fahri , SAYDAM Güray , KOSOVA Buket
Published: June 2022

Amaç: Miyelodisplastik sendrom (MDS) akut miyeloid lösemiye dönüşüm riski yüksek olan, artmış apoptozis ve azalmış hematopoez oranlarıyla karakterize klonal bir hastalıktır. MDS patogenezi tam olarak açıklanabilmiş değildir. Olguların ~%50' si anormal karyotiptedir ve bu oran ikincil MDS' de %80 civarındadır. P53 proteini kök hücre homeostazının önemli düzenleyicisidir ve hücre döngüsünün düzenlenmesi, apoptotik ile enflamatuar yanıt gibi bir dizi hücresel olayda yer alır. Genomik bütünlüğün korunmasında da önemli görevleri bulunan TP53 geni kanserlerde sıklıkla mutasyona uğramaktadır; ancak, mutasyonlarının yanında bazı gen polimorfizmlerinin de kanserle ilişkili oldukları bilinmektedir. Çalışmadaki amacımız, dört yaygın p53 tek nükleotid polimorfizminin MDS’ deki yaygınlıklarını ve hastalık gelişimi üzerine etkilerini belirlemektir. Bu amaçla, Ege Üniversitesi Tıp Fakültesi Dahiliye Anabilim Dalı Hematoloji Bilim Dalı' nda MDS tanısı ile takip edilen ya da yeni tanı almış 100 olgu çalışmaya dahil edildi.
Gereç ve Yöntem: MDS’li olguların periferik kan lökositlerinden izole edilen DNA’lar gerçek-zamanlı PCR yöntemiyle çalışılarak, p53 polimorfizmleri (rs35163653, rs35993958, rs1800371, rs1042522) uygun probların kullanımıyla ve erime eğrisi analizleriyle belirlendi.
Bulgular: İncelenen dört yaygın p53 polimorfizmin arasında özellikle rs1042522 polimorfizmindeki atasal olmayan G alelinin MDS’li olgularda artmış olduğu gözlenmiştir (C:%30.3; G:%69.7). Fonksiyonel olduğu, yani sentez edilen proteinin fonksiyonunu etkilediği bilinen bu polimorfizmde 417. pozisyonundaki C nukleotidinin G’ye transisyonu (C>G), proteinin 72. pozisyonundaki prolin amino asidinin arjinine (P72R) kodlanmasına yol açmaktadır.
Sonuç: Çalışmamız, MDS hastalık grubunda rs35163653, rs35993958, rs1800371 ve rs1042522 p53 polimorfizmlerinin araştırıldığı ilk çalışmadır. Bunlardan, rs1042522 polimorfizminin kansere yatkınlık ve duyarlılıkla ilişkili olduğu yapılan diğer bazı çalışmalarla gösterilmiş olması nedeniyle, MDS hastalığı için de yüksek risk oluşturabileceği düşünülmektedir. Sonuç olarak, MDS hastalığı için gerçekleştirilen bu çalışmanın daha geniş bir olgu grubuyla tekrarlanmasıyla rs1042522 polimorfizmi ileride MDS teşhisinde belirteç olarak kullanılabilecektir.
Could diabetes mellitus be a risk factor for postoperative hypoparathyroidism?
Authors: CAN Bülent , AGAÇ Zubeyr Said , ÇETİN Zeynep
Published: June 2022

Aim: Postoperative hypoparathyroidism (postop hypoPT) is usually seen after aggressive neck surgery, and can be fatal if left untreated. To the best our knowledge there is no study in literature that directly investigates the association between diabetes mellitus (DM) and postop hypoPT. In this study, we aimed to determine whether DM increases the risk of permanent postop hypoPT.
Materials and Methods: Patients presenting to endocrinology outpatient clinic with a diagnosis of permanent postoperative hypoparathyroidism, were studied retrospectively. Patients older than 18 years of age were included in the study if one year had passed after the neck operation.
Results: The average age of 131 patients who met the inclusion criteria was 49 ± 12. 93.9% of the patients were women and the patients were generally obese or overweight (mean body mass index= 30±5.29 kg/m2). While 14.5% of the patients were diabetic and 32.8% prediabetic (47.3% had impaired carbohydrate tolerance), 52.7% had normal glucose metabolism.
Conclusion: The rate of DM / prediabetes (preDM) in patients diagnosed with postop hypoPT and the prevalence of DM / preDM in Turkish population were similar. Even though DM is associated with endothelial dysfunction, our findings suggest that DM is not a risk factor for postop hypoPT.
Perinatal trends and birth outcomes of Syrian refugee and turkish women
Authors: İLERİ Alper , ATA Can , İLERİ Hande , YILDIRIM KARACA Suna , ŞENKAYA Ayşe Rabia
Published: June 2022

Aim: The impact of migration on health is far-reaching, making migrant populations particularly vulnerable, fueling health inequalities and resulting in serious implications for global health. The aim of our study to assess antenatal care, pregnancy and neonatal outcomes of Syrian refugee women in Turkiye.
Material and Methods: Syrian and Turkish pregnants who delivered between 2013-2019 were recruited and categorized into groups according to maternal age at delivery. First trimester combined test, second trimester triple test, preterm delivery, maternal anemia; neonatal stillbirth, APGAR scores, birth weight and breastfeeding status were assessed.
Results: 4992 Syrian and 6846 Turkish pregnants were included. Maternal anemia was higher in Turkish patients in 20-34 and ≥35 groups. First trimester combined test, APGAR scores and birth weights were lower in Syrian women. Preterm rates higher in Turkish patients in only 20-34 age group. Second-trimester triplet tests were only higher in Turkish women in ≥35 age group. Low birth weight was higher in younger Syrian patients. Satisfying breastfeeding results were found in Syrian women.
Conclusion: Our study stated that Syrian women are at risk of low birth weight in adolescent and 20-34 age groups and low rates in first trimester combined test in all age groups. However decreased risk of pregnancy complications such as maternal anemia, preterm delivery, cesarean delivery and satisfying breastfeeding results were found in Syrian patients.
Tradução, Adaptação Cultural e Contributos para a Validação da Escala Nijmegen Cochlear Implant Questionnaire (NCIQ) para o Português Europeu
Authors: Roque Reis Luis , Castelhano Luís , Gani Kaamil , Correia Filipe , Nunes Gonçalo , Santos Ricardo , O'Neill Assunção , Escada Pedro
Published: June 2022

Introdução: O questionário Nijmegen Cochlear Implant Questionnaire (NCIQ) consiste numa escala simples e de rápida aplicação para avaliar a satisfação dos indivíduos que utilizam implantes cocleares. O objetivo deste estudo foi a validação do NCIQ para o Português Europeu e avaliação da qualidade de vida em adultos utilizadores de implantes cocleares. Material e Métodos: Participaram no estudo 50 adultos utilizadores de implante coclear multicanal (uni ou bilateral), com surdez pós-lingual, no mínimo com 12 meses de uso, implantados e seguidos no serviço de Otorrinolaringologia do Hospital Egas Moniz em Lisboa. Foram pedidas a autorização e as normas para a tradução do questionário aos autores da escala e realizada a tradução e retroversão do questionário, a adaptação cultural, e a avaliação da reprodutibilidade e da consistência interna.Resultados: Os participantes eram 44,0% do género masculino e 56,0% do feminino, com idades compreendidas entre os 20 e os 79 anos (55,50 ± 15,69). Os resultados obtidos neste estudo demonstraram um nível de satisfação global de 65,07 nos utilizadores de implantes cocleares. O nível de satisfação dos subdomínios foi de 64,40 na perceção básica do som, 71,35 na perceção avançada do som, 57,91 na produção da fala, 59,05 na autoestima, 69,75 na atividade e 68,50 nas interações sociais. A versão traduzida do questionário NCIQ apresentou uma boa consistência interna para todos os domínios existentes no questionário (α de Cronbach = 0,96). Verificou-se também uma boa reprodutibilidade inter-pesquisadores. Para a pontuação global e das subescalas do questionário, os resultados médios obtidos demonstraram não haver diferenças significativas com a escala original.Conclusão: A adaptação do Nijmegen Cochlear Implant Questionnaire para Português Europeu deve ser considerada um bom instrumento para a avaliação da satisfação dos utilizadores de implantes cocleares e é, até ao momento, a única escala neste domínio validada para aplicação na população portuguesa.
The Effectiveness of Time Equilibration Before Freezing in Sapera Goat Spermatozoa After Electric Separating Sperm
Authors: Saputro Amung Logam , Prastiya Ragil Angga , Ulinuha Meidina Zulva , Widayani Prasita
Published: June 2022

The purpose of this study was to determine the effectiveness of time equilibration before freezing sapera goat spermatozoa after ESS (Electric Separating Sperm) on motility, viability, membrane integrity, normality and abnormality of spermatozoa. Sapera goat spermatozoa were collected using an artificial vagina and then separated using the ESS method. This study used a completely randomized formula with three treatments, which are the equilibration time of P1 (1 hour), P2 (3 hours), and P3 (4 hours), with six replications. The analysis in this study used the ANOVA test followed by the Duncan test to determine the real difference between treatments. The conclusion of this study showed the highest percentage of motility, viability, membrane integrity, normality of sapera goat spermatozoa at 1-hour treatment, for the lowest percentage of abnormalities at 1-hour treatment. Significantly different results (p <0.05) on the anode and cathode sides in all equilibration time treatments.
Surgical Procedure for Pyometra and Mammae Tumor Treatment in a Pitbull Dog
Authors: Rickyawan Nofan , Virgiantari Cheptien Winda , Lesmana Muhamad Arfan , Vidiastuti Dian
Published: June 2022

Pyometra is an infection or inflammation of the uterine wall characterized by the accumulation of pus in the uterine lumen. Predisposing factors include age, breed, bacterial infection, and hormones. Another disease that is often correlated with an imbalance in reproductive hormones is mammary tumors. A 7-year-old unspayed female Pitbull dog weighed 27.9 kg has clinical symptoms of frequent discharge of mucopurulent reddish-brown discharge with a foul odor from the vagina. The left mammary glands of the second, third, and fourth nipples have lumps about 20 cm in diameter, are solid in consistency, well-defined, the same color as the skin surface, and can be moved. Diagnosis performed on physical examination, hematology, blood chemistry, and cytology was pyometra and mammary tumors. Treatment was done by ovariohysterectomy and unilateral mastectomy. Post-surgery therapy was enrofloxacin 5 mg/kg, ketoprofen 2 mg/kg, phytomenadione 1 mg/kg, and Biodin® 0.1 ml/kg, followed by intensive surgical wound care. The patient recovered after two months of treatment.
Medical Treatment for Pyometra in Cat
Authors: Palupi Tantri Dyah Whidi , Suprayogi Tri Wahyu , Ismudiono Ismudiono
Published: June 2022

The Pyometra case is a case that is often found in Female Cat. This case report will discuss the handling of a case of pyometra in a 7-year-old mixed breed cat who is being treated at Harmoni Pet Care, Menanggal, Gayungan, Surabaya, Indonesia. Reports from the owner that these cats are still in good appetite but sanguino-purulent discharge from the vagina was found. In clinically diagnosed with a pyometra, the treatment used to treat pyometra case was ovariohysterectomy. Postoperative care was carried out by administering antibiotics (Clanexi; Amoxicillin-Clavulanic Acid, 1 cc/kg, IM) given twice a day for 14 days, with the first 3 days being treated in the Harmoni Pet Care inpatient room and the 4th day to the 14th day of care is done at the owner's house, local antiseptic dressing at the incision site is continued for up to 14 days until the sutures in the skin sutures were absorbed by the cat's body.
Morphometry Identification of Lice on Male Javan Langur (Trachypithecus auratus)
Authors: Titisari Nurina , Cahyaningrum Yunita , Yesica Reza , Rickyawan Nofan
Published: June 2022

A rehabilitation center for Javan Lutung animals in East Java carries out routine checks on rehabilitated animals to prevent diseases that can affect health. Diseases that can infect these endangered animals are not only diseases that are inside the body but also outside the body such as lice infestation. The purpose of this study was to identify the species of louse that attack Javan langurs in an effort to increase information on ectoparasite species in these endemic animals. The sample was obtained from an adult Javan langur, then the sample was preserved by the unstained Slide mounting method. The results were observed using a microscope and body length was measured using the ImageJ software. The results showed that the ectoparasite shape has a flat-dorsoventral body with a total body length of 1.65 mm. From morphometry and morphological characteristics, the samples identified were the male species of Pedicinus ancoratus.
Comparison of Antigenicity Between Local and Massachusetts Strains of Infectious Bronchitis Virus using Indirect ELISA Test
Authors: Rahmahani Jola , Akbar Daniswara Irwanza , Suwarno Suwarno
Published: June 2022

The aim of this study was to compare the antigenicity between the whole virus and protein S of both local strain I-147 and Massachusetts strain of Infectious bronchitis virus with indirect ELISA. We used 10 positive serums from post vaccinated chickens for further reaction with four groups of antigens in this study that are: P1) S protein (spike glycoprotein) antigen of local strain IB virus; P2) S protein (spike glycoprotein) antigen of Massachusetts strain IB virus; P3) whole virus antigen of local strain IB virus; P4) whole virus antigen of Massachusetts strain IB virus. The results of this research are Optical Density (OD) values of each treatment, then to be analyzed using One Way ANOVA and followed by Duncan Multiple Range Test 5%. The results show that there are differences between the antigenicity of the whole virus and S protein in both local strain and Massachusetts strain of IB virus. The whole virus antigen of both strains has a significant difference (p<0.05) with the S protein antigen in both strains. Specifically, the whole virus antigen of Massachusetts strain has the highest OD among the other groups.
Study of Performance Index and Business Analysis on Chicken Infected by Escherichia coli with Probiotic Provision of Lactic Acid Bacteria
Authors: Abdurrahman Farid , Soeharsono Soeharsono , Soepranianondo Koesnoto
Published: June 2022

This study was conducted to determine the performance index and business analysis of broilers infected with Escherichia coli by administering lactic acid bacteria probiotics in the form of Lactoped® (Lactobacillus casei, Lactobacillus plantarum, Lactobacillus fermentatum, Lactobacillus acidophilus). This type of research was true experimental research using a post-test-only control group design. The design used in this study was a completely randomized design (CRD). 30 broilers were randomized into three treatments (P0, P1 and P2) in each group with a minimum of six times. Probiotic lactic acid bacteria (LAB) with a concentration of 108 CFU/ml in broilers infected with Escherichia coli showed a higher performance index. It could cover the entire fixed costs so still feasible to do, meanwhile, for the scale of research (10 heads/treatment), it was not yet feasible to implement due to it has suffered losses.
Risk Factors and Scabious Prevalence in Cats During 2020 in Griya Satwa Clinic, Magetan
Authors: Cahya Nedriana , Primarizky Hardany , Yunita Maya Nurwartanti
Published: June 2022

Scabious is a disease that often infests cats, originating from the family Sarcoptidae. This study aimed to determine the prevalence and factors that can affect the risk of scabious in cats. The study was evaluated at the Griya Satwa Clinic, Magetan in January-February 2021. The design of this study was a retrospective cohort study by taking secondary data during the 2020 period as study material. The data obtained were then entered into the Statistical Package for the Social Sciences (SPSS) version 20 for windows to analyze the association's relationship and increased risk by calculating the Chi-Square and Odds Ratio. The samples obtained were 76 cats infested with scabious. The analysis of the association of risk factors for scabious was breed (P = 0.428), age (P = 0.793), sex (P = 0.426). The results of the prevalence of scabious in cats from the study during January-February 2021 in the 2020 period were 9.5%, and the analysis of the association (Chi-Square) and the increased (Odds Ratio) of factors including breed, age, sex on the risk of scabious in cats were not significance / absent influence, The probability of error obtained is outside the tolerance set by the researcher, so the results are not significant (p>0,05).
Business Analysis of Probiotic Administration of Lactic Acid Bacteria on The Performance of Kampung Super Chicken
Authors: Utomo Gogik Satrio Margo , Hidanah Sri , Al Arif Muhammad Anam , Lokapirnasari Widya Paramita , Yuniarti Wiwik Misaco
Published: June 2022

This study aimed to determine the effect of lactic acid bacteria probiotics on the performance of kampung super chicken. Kampung super chicken is the result of a cross between a layer chicken and a superior kampung super chicken. A total of 48 kampung super chickens aged 14 days were randomized into 4 treatments and each treatment consisted of 12 chickens. This study was conducted for 1 week of adaptation and 5 weeks of treatment. This study used 4 different treatments including P0 not using probiotics, P1 using probiotics as much as 1 ml/liter drinking water, P2 using probiotics as much as 2 ml/liter drinking water and P3 using probiotics as much as 4 ml/liter drinking water. In conclusion, based on the results of the Analysis of Variance (ANOVA) showed that p<0.05, which means that the data had a significant difference in the final weight increase, carcass weight increase and carcass weight percentage to the control treatment.
Exploring the challenges of forensic technology in responding to credit card fraud in Sedibeng Region, South Africa
Authors: Motseki Morero , Tseko Mofokeng Jacob
Published: June 2022

Today use of Credit Card even in developing countries has become a common scenario. People use it to shop, pay bills and for online transactions. This study explored the challenges of forensic technology in responding to credit card fraud as an approach used by the South African Police Service (SAPS) in Sedibeng region. This study was carried out utilising a qualitative approach and thirty nine interviews were carried out among officials deployed in the SAPS, community leaders, members of the community and bank managers. The key findings indicated that the challenges in responding to this scourge is that the perpetrators utilise advanced technologies resources (computer hacking software) as opposed to SAPS which does not have systems nor capacity to effectively respond to this crime. The limited resources to respond to this crime adequately. For recommendations; significant emphases should be directed on the promotion of public awareness through public education. The intensive training of SAPS officials and inter-governmental collaboration between the SAPS, community police forums, bank managers and South African Banking Risk Information Centre (SABRIC) in understanding this technology are highly advised.
A criminological study on obstacles to the response to human trafficking in Durban Metropolitan
Authors: Nkosi Sphamandla Lindani , Mphatheni Mandlenkosi Richard
Published: June 2022

Human trafficking has plagued the rights of many people worldwide, and it has continually put their protection in jeopardy. Thus, a need to explore the challenges and barriers encountered by stakeholders such as the South Africa Police Service (SAPS) and non-government organisations (NGOs) to respond to this scourge remains essential. The study understood the obstacles to combatting human trafficking in Durban Metropolitan through in-depth interviews. The findings of this study revealed loopholes in measurements of human trafficking; for instance, instability in partnerships of relevant stakeholders adversely impacts the fight against the menace of human trafficking. Also, current resources are perceived to be minimal to match the severity of this crime. As a recommendation, SAPS and NGOs should advance their technological capacities, and acquiring appropriate knowledge and regular training of officials should remain the focal point of any response to human trafficking. Moreover, technological advancement should match or surpass the sophistication in crime commission to rapidly identify human traffickers and victimisation instances.
“Why fix it if ain’t broke”: Nature and extent of crime in the railway environment in South Africa
Authors: Madzivhandila Cynthia , Mofokeng Jacob , Motsepe Lesiba L.
Published: June 2022

This article explores the nature and extent of crime in the railway environment in South Africa. Crimes against Passenger Rail Agency of South Africa, Transnet Freight Rail, Gautrain, and commuters are prevalent and the victims are being exposed to serious damage emanating from criminal activities. The challenges and implications for individuals and businesses, rich or poor consumers are recurrent themes in this study. A qualitative research approach was adopted to follow a non-probability purposive sample comprising 25 participants from the South African Police Service Rapid Rail Police Units. The data were collected through semi-structured interviews from research participants deployed in the Division: Visible Policing. The findings highlighted that the most prevalent crimes are cable theft, robberies and malicious property damage. The targeted trains are the Metro trains that operate locally, as they transport many commuters because it is the affordable mode of public transport in South Africa. The perpetrators also target this mode of transport because the train stations have an open system where perpetrators can easily access the entrance, therefore some do not even buy tickets and board the trains illegally. It is understood that Gautrain has a closed system and the security is advanced and watertight because of extra security measures such as the closed-circuit television cameras. Based on the findings, effective implementation of policies to improve safety is essential. Critical dialogues between all relevant.