bluuebunny/crossref_metadata_2025 huggingface dataset:
Histological assessment of a septum in the first dorsal compartment: a fresh cadaver study
Authors: Sugiura Shiro , Matsuura Yusuke , Suzuki Takane , Nishikawa Satoru , Kuniyoshi Kazuki , Ohtori Seiji
Published: March 2019

Resistance of de Quervain’s disease to conservative treatment has been associated with an intertendinous septum in the first compartment; little is known about the histological features of such a septum. This study aimed to examine the intertendinous septum histologically and note its variations. After dissecting the first extensor compartment of 24 hands from 12 fresh frozen cadavers, the presence of any intertendinous septa was determined. The length of the extensor retinaculum and intertendinous septum was measured; histological findings of the first compartment with or without septa were studied and compared with those of the third/fourth compartment. Intertendinous septa were observed in 12 of 24 wrists. Histological assessment of the intertendinous septum revealed tissue similar in composition to the retinaculum observed between the third and fourth compartments.
Pan-European Economic Analysis to Identify Cost Savings for the Health Care Systems as a Result of Integrating Glucose Monitoring Based Telemedical Approaches Into Diabetes Management
Authors: Fritzen Katharina , Basinska Kornelia , Rubio-Almanza Matilde , Nicolucci Antonio , Kennon Brian , Vergès Bruno , Zakrzewska Katerina , Schnell Oliver
Published: March 2019

Background:

Self-monitoring of blood glucose supported by the diabetes-app OneTouch Reveal® has demonstrated to improve HbA1c. We aimed at analyzing costs savings related the integration of telemedical features into diabetes management.

Methods:

Data from a randomized controlled trial were used to assess the 10-year risk of patients for fatal myocardial infarction (MI). On the basis of this risk assessments—also related to a 5% or 10% reduction of hypoglycemic episodes—cost savings for the health care systems of five European countries—France, Germany, Italy, Spain, and the United Kingdom—were modeled.

Results:

HbA1c reduction of 0.92% in insulin-treated type 2 diabetes patients (T2DM) was associated with a 2.3% decreased 10-year risk for fatal MI. In combination with a 10% reduction of hypoglycemic events this risk reduction led to cost savings of €16.1 million (France), €57.8 million (Germany), €30.9 million (Italy), €23.8 million (Spain), and €5.8 million (UK), considering all insulin-treated T2DM patients in the respective countries.

Conclusion:

Improving metabolic control and thus risk for comorbidities like MI by combining the glucose meter with CRI with telemedical features has the potential to reduce costs for European health care systems.
Sex Differences in Common Sports-Related Injuries
Authors: Matzkin Elizabeth , Garvey Kirsten
Published: March 2019

Sex plays a role in mediating different susceptibilities and outcomes of disease and injury. Sports injuries are included in this phenomenon, as recent research demonstrates that males and females show differences in incidences of varying injuries, presentations of injury, and treatment outcomes. Incidence of certain sports injuries like anterior cruciate ligament injury or patellofemoral pain syndrome may vary widely between male and female athletes, with female athletes being more susceptible to anterior cruciate ligament injury and patellofemoral pain syndrome. Treatment outcomes for males and females may also vary widely. For example, males have a higher risk of recurrent shoulder instability compared with females. These variances among incidence and outcome following certain injuries highlight the necessity of understanding these differences to provide quality care. It is especially important for the school nurse to be aware of these sex differences as they are well positioned to make youth athletes and their families aware of the varying injury susceptibilities among them.
Capturing the personal through the lens of the professional: The use of external data sources in autoethnography
Authors: Lee Catherine
Published: March 2019

This article shows how external data sources can be utilised in autoethnographic research. Beginning with an account of a critical incident that examines the incompatibility of private and professional identities, I show how, through the collection of data sources, I capture the impact of homophobic and heteronormative discursive practices on health, wellbeing and identity. In the critical incident, I explore how I prospered as a teacher at a British village school for almost 10 years by censoring my sexuality and carefully managing the intersection between my private and professional identities. However, when a malicious and homophobic neighbour and parent of children at the school exposed my sexuality to the Headteacher, I learned the extent to which the rural school community privileged and protected the heteronormative discourse. A poststructuralist theoretical framework underpins this article. My experience of being a subject is understood as the outcome of discursive practices. Sexual identity, teacher identity and autoethnographer identity are understood to be fluid, and constantly produced and reproduced in response to social, cultural and political influences. The article describes how email correspondence, medical records and notes from a course of cognitive behaviour therapy were deployed to augment my personal recollection and give a depth and richness to the narrative. As the critical incident became a police matter, examination takes place of how I sought to obtain and utilise data from the police national computer in the research. Attempts to collect data from the police and Crown Prosecution Service were problematic and provided an unexpected development in the research and offered additional insight into the nature of the British rural community and its police force.
Beryllium Standard Update
Authors: Phillips Jennan A.
Published: March 2019

The updated Occupational Safety and Health Administration’s (OSHA) beryllium standard for general industry, construction, and shipyards reduced exposure limits for this known human carcinogen and became effective in 2018. Occupational and environmental health nurses need to monitor updates recently proposed for general industry to clarify implementation of the standard.
Mental health screening for children in care using the Strengths and Difficulties Questionnaire and the Brief Assessment Checklists: Guidance from three national studies
Authors: Tarren-Sweeney Michael , Goemans Anouk , Hahne Anna Sophie , Gieve Matthew
Published: March 2019

Although children residing in statutory out-of-home care and those adopted from care are more likely than not to have mental health difficulties requiring clinical intervention or support, their difficulties often remain undetected. Children’s agencies have a duty of care to identify those child clients who require therapeutic and other support services, without regard to the availability of such services. The present article proposes a first-stage mental health screening procedure (calibrated for high sensitivity) for children and adolescents (ages 4–17) in alternative care, which children’s agencies can implement without clinical oversight using the Strengths and Difficulties Questionnaire (SDQ) and Brief Assessment Checklists (BAC). The screening procedure was derived from analyses of BAC, SDQ, and “proxy SDQ” scores obtained in three national studies of children and adolescents residing in alternative care (Australia, the Netherlands, and England). The SDQ and BAC demonstrated moderate to high screening accuracy across a range of clinical case criteria—the SDQ being slightly better at predicting general mental health problems and the BAC slightly better at predicting attachment- and trauma-related problems. Accurate first-stage screening is achieved using either the SDQ or the BAC alone, with recommended cut points of 10 (i.e., positive screen is 10 or higher) for the SDQ and 7 for the BAC. Greater accuracy is gained from using the SDQ and BAC in parallel, with positive screens defined by an SDQ score of 11 or higher or a BAC score of 8 or higher. Agencies and post-adoption support services should refer positive screens for comprehensive mental health assessment by clinical services.
Risk assessment in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Authors: Humbert Marc , Farber Harrison W. , Ghofrani Hossein-Ardeschir , Benza Raymond L. , Busse Dennis , Meier Christian , Hoeper Marius M.
Published: March 2019

Background

Current pulmonary hypertension treatment guidelines recommend use of a risk stratification model encompassing a range of parameters, allowing patients to be categorised as low, intermediate or high risk. Three abbreviated versions of this risk stratification model were previously evaluated in patients with pulmonary arterial hypertension (PAH) in the French, Swedish and COMPERA registries. Our objective was to investigate the three abbreviated risk stratification methods for patients with mostly prevalent PAH and chronic thromboembolic pulmonary hypertension (CTEPH), in patients from the PATENT-1/2 and CHEST-1/2 studies of riociguat.

Methods

Risk was assessed at baseline and at follow-up in PATENT-1 and CHEST-1. Survival and clinical worsening-free survival were assessed in patients in each risk group/strata.

Results

With all three methods, riociguat improved risk group/strata in patients with PAH after 12 weeks. The French non-invasive and Swedish/COMPERA methods discriminated prognosis for survival and clinical worsening-free survival at both baseline and follow-up. Furthermore, patients achieving one or more low-risk criteria or a low-risk stratum at follow-up had a significantly reduced risk of death and clinical worsening compared with patients achieving no low-risk criteria or an intermediate-risk stratum. Similar results were obtained in patients with inoperable or persistent/recurrent CTEPH.

Conclusions

This analysis confirms and extends the results of the registry analyses, supporting the value of goal-oriented treatment in PAH. Further assessment of these methods in patients with CTEPH is warranted.
Comparing Paclitaxel Plus Fluorouracil Versus Cisplatin Plus Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Cancer: A Randomized, Multicenter, Phase III Clinical Trial
Authors: Chen Yun , Ye Jinjun , Zhu Zhengfei , Zhao Weixin , Zhou Jialiang , Wu Chaoyang , Tang Huarong , Fan Min , Li Ling , Lin Qin , Xia Yi , Li Yunhai , Li Jiancheng , Jia Huixun , Lu Saiquan , Zhang Zhen , Zhao Kuaile
Published: March 2019

PURPOSE

This trial aimed to assess the efficacy and safety of the paclitaxel plus fluorouracil regimen versus the cisplatin plus fluorouracil regimen in definitive concurrent chemoradiotherapy (dCRT) in patients with locally advanced esophageal squamous cell carcinoma (ESCC).

PATIENTS AND METHODS

Patients with locally advanced ESCC were enrolled and randomly assigned to either the paclitaxel plus fluorouracil group or the cisplatin plus fluorouracil group. The patients in the paclitaxel plus fluorouracil group were treated with paclitaxel and fluorouracil one cycle per week in dCRT for five cycles followed by paclitaxel and fluorouracil one cycle per month in consolidation chemotherapy for two cycles. The patients in the cisplatin/5-fluorouracil group were treated with cisplatin and fluorouracil one cycle per month in dCRT for two cycles followed by two cycles in consolidation chemotherapy. The radiotherapy dose was 61.2 Gy delivered in 34 fractions. The primary end point was 3-year overall survival (OS).

RESULTS

Four hundred thirty-six patients with ESCC in six centers were recruited at a 1:1 ratio between April 2012 and July 2015. The median follow-up of the surviving patients was 48.7 months (interquartile range, 42.6-60.9). The 3-year OS was 55.4% in the paclitaxel plus fluorouracil group and 51.8% in the cisplatin plus fluorouracil group (hazard ratio, 0.905 [95% CI, 0.698 to 1.172]; P = .448). The 3-year progression-free survival was also not significantly different between the paclitaxel plus fluorouracil group and the cisplatin plus fluorouracil group (43.7% v 45.5%, respectively; hazard ratio, 0.973 [95% CI, 0.762 to 1.243]; P = .828). Compared with the cisplatin plus fluorouracil group, the paclitaxel plus fluorouracil group had significantly lower incidences of acute grade 3 or higher anemia, thrombocytopenia, anorexia, nausea, vomiting, and fatigue ( P < .05), but higher incidences of acute grade 3 or higher leukopenia, radiation dermatitis, and radiation pneumonitis ( P < .05).

CONCLUSION

The paclitaxel plus fluorouracil regimen did not significantly prolong the OS compared with the standard cisplatin plus fluorouracil regimen in dCRT in patients with locally advanced ESCC.
Counseling and Management of the Risks of Living With Epilepsy
Authors: Noe Katherine
Published: March 2019

PURPOSE OF REVIEW

For patients living with epilepsy, quality of life is determined not only by seizure control but by mood, antiepileptic drug adverse effects, relationships, and access to education, employment, and transportation. This article reviews some of the most commonly encountered concerns associated with epilepsy, including mood disorders, driving, injuries, mortality, bone health, genetic burden, and impact on relationships.

RECENT FINDINGS

People with epilepsy are at increased risk for anxiety, depression, and suicide. Depression is underrecognized in patients with epilepsy, but effective validated screening tools are available for use. Mortality rates for people with epilepsy are 2 times higher than those of the general population, but much of this is attributable to underlying conditions rather than seizures. Sudden unexpected death in epilepsy (SUDEP) occurs in an estimated 1:1000 adults with epilepsy per year, and the risk can be reduced by improved observation and seizure control. An increased risk of injury, including fractures, is also present in patients with epilepsy. Reduced bone health leading to increased fracture risk is an important negative consequence of long-term use of antiepileptic medication. Seizures while driving can also cause accidents and injury. Despite the importance of driving for people with epilepsy, physicians are underperforming in providing counsel about driving.

Optimal care of the patient with epilepsy includes addressing risks to emotional health, physical health including fractures and SUDEP, social health, and an independent lifestyle. Identification of and treatments to reduce these risks can do more to improve quality of life than a narrow clinical focus on seizure control alone.
Treatment of Women With Epilepsy
Authors: Sazgar Mona
Published: March 2019

PURPOSE OF REVIEW

This article provides the latest information to guide practitioners in counseling and treating women with epilepsy.

RECENT FINDINGS

There is an increasing body of literature on the multidirectional effects of sex hormones on seizure frequency and severity and of seizures altering areas of the brain involved in neuroendocrine function. Ongoing pregnancy outcome data from pregnancy registries and meta-analysis of observational studies have provided key information on the safety of using antiseizure medications during pregnancy and the risk to the fetus.

In treating and counseling women with epilepsy from puberty to menopause, it is important to understand the complex interactions of sex hormones, seizures, and antiseizure medications on reproductive health and pregnancy outcomes.
C1–C2 Motion During C-MAC D-Blade Videolaryngoscopy and Endotracheal Intubation in 2 Patients With Type II Odontoid Fractures: A Case Report
Authors: Hindman Bradley J. , Woodroffe Royce W. , Zanaty Mario , Kawasaki Hiroto , Yamaguchi Satoshi , Puttlitz Christian M. , Gadomski Benjamin C.
Published: March 2019

Laryngoscopy and endotracheal intubation in patients with unstable cervical spines may cause pathological spinal motion and resultant cord injury. Cadaver and mathematical (finite element) models of a type II odontoid fracture predict C1–C2 motions during intubation to be of low magnitude, especially with the use of a low-force videolaryngoscope. Using continuous fluoroscopy, we recorded C1–C2 motion during C-MAC D videolaryngoscopy and intubation in 2 patients with type II odontoid fractures. In these 2 patients, C1–C2 extension and change in C1–C2 canal space were comparable to motions predicted by cadaver and finite element models and did not cause neurological injury.
Blood Flow–restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial
Authors: AMPOMAH KWASI , AMANO SHINICHI , WAGES NATHAN P. , VOLZ LAUREN , CLIFT RACHEL , LUDIN ARIMI FITRI MAT , NAKAZAWA MASATO , LAW TIMOTHY D. , MANINI TODD M. , THOMAS JAMES S. , RUSS DAVID W. , CLARK BRIAN C.
Published: March 2019

Purpose

The goal of this trial was to determine whether low-load blood flow–restricted (BFR) exercise of appendicular muscles induces a cross-transfer of effect to the trunk extensor (TE) muscles, such that low-load TE exercise would enhance TE size and function to a greater extent than standard low-load exercise in people with recurrent low back pain (LBP). We also investigated the direct effects of BFR exercise in the appendicular muscles.

Methods

Thirty-two adults with recurrent, nonspecific LBP were randomized into two groups: Appendicular BFR exercise (BFR exercise) or control exercise (CON exercise). All participants trained (two times per week) for 10 wk, with a 12-wk follow-up. Participants performed three sets of leg extension (LE), plantar flexion (PF), and elbow flexion (EF) exercises followed by low-load TE exercise without BFR. Outcome measures included magnetic resonance imaging–derived muscle size (quadriceps and TE), strength (LE, PF, EF, and TE), and endurance (LE and TE).

Results

There was no evidence for a cross-transfer of effect to the TE. There was also no statistically significant enhancement of limb skeletal muscle size or function of BFR relative to CON exercise at any time point; though, moderate effect sizes for BFR exercise were observed for enhanced muscle size and strength in the leg extensors.

Conclusions

Low-load BFR exercise of the appendicular muscles did not result in a cross-transfer of effect to the TE musculature. There was also no significant benefit of low-load BFR exercise on the appendicular muscle size and function, suggesting no benefit from low-load BFR exercise in adults with recurrent, nonspecific LBP.
Physiological Evaluation for Endurance Exercise Prescription in Sickle Cell Disease
Authors: MESSONNIER LAURENT A. , GELLEN BARNABAS , LACROIX ROXANE , PEYROT SANDRINE , RUPP THOMAS , MIRA JOSÉ , PEYRARD ARTHUR , BERKENOU JUGURTHA , GALACTÉROS FRÉDÉRIC , BARTOLUCCI PABLO , FÉASSON LÉONARD
Published: March 2019

Purpose

Although strenuous exercise may expose sickle cell disease (SCD) patients to risks of vaso-occlusive crisis, evidence suggests that regular endurance exercise may be beneficial. This study aimed to test (i) the safety and usefulness of a submaximal incremental exercise in evaluating physical ability of SCD patients and identify a marker for the management of endurance exercise and (ii) the feasibility of endurance exercise sessions in SCD patients.

Methods

Twenty adults with SCD (12 men and 8 women) performed a submaximal incremental exercise used to determine the first lactate threshold (LT1) and stopped as soon as blood lactate concentration ([lactate]b) reached ≥4 mmol·L−1. Fifteen of those patients (8 men and 7 women) also performed three 30-min endurance exercise sessions at ~2.5 mmol·L−1 of [lactate]b on separate occasions.

Results

LT1 occurred at 47 ± 3 and 33 ± 3 W for men and women, respectively, demonstrating the extreme deconditioning and, thus, low physical ability of adult SCD patients. During endurance exercise, peripheral oxygen saturation and [lactate]b most often remained stable and within acceptable ranges.

Conclusions

The proposed strategy of submaximal incremental exercise allowed safe determination of LT1, an important parameter of patients’ physical ability. The study also demonstrated the feasibility and safety of individually tailored endurance exercises at ~2.5 mmol·L−1 of [lactate]b. These latter results suggest that endurance training programs may be considered for adult SCD patients and that the method proposed here may be helpful in that regard.
Delegated Expertise, Authority, and Communication
Authors: Deimen Inga , Szalay Dezs˝o
Published: March 2019

A decision maker needs to reach a decision and relies on an expert to acquire information. Ideal actions of expert and decision maker are partially aligned and the expert chooses what to learn about each. The decision maker can either get advice from the expert or delegate decision making to him. Under delegation, the expert learns his privately optimal action and chooses it. Under communication, advice based on such information is discounted, resulting in losses from strategic communication. We characterize the communication problems that make the expert acquire information of equal use to expert and decision maker. In these problems, communication outperforms delegation. (JEL D82, D83)
Targeting with In-Kind Transfers: Evidence from Medicaid Home Care
Authors: Lieber Ethan M. J. , Lockwood Lee M.
Published: March 2019

Making a transfer in kind reduces its value to recipients but can improve targeting. We develop an approach to quantifying this tradeoff and apply it to home care. Using randomized experiments by Medicaid, we find that in-kind provision significantly reduces the value of the transfer to recipients while targeting a small fraction of the eligible population that is sicker and has fewer informal care-givers than the average eligible. Under a wide range of assumptions within a standard model, the targeting benefit exceeds the distortion cost. This highlights an important cost of recent reforms toward more flexible benefits. (JEL D82, H51, H75, I18, I38)
Critical aspects in research infrastructure management
Authors: Souyioultzoglou Irakleitos
Published: March 2019

As the scholarly communication landscape is constantly evolving, the development of an ecosystem of infrastructures supporting digitally-oriented research practices becomes a necessity. This paper is a contribution to the ongoing discussion on the sustainability of digital research infrastructures∙ it describes four key operating principles and their interrelationships.
Psychotherapy in the era of artificial intelligence: Therapist Panoptes
Authors: Brailas Alexios
Published: March 2019

“What will happen when an artificial intelligence entity has access to all the information stored about me online, with the ability to process my information efficiently and flawlessly? Will such an entity not be, in fact, my ideal therapist?” Would there ever come a point at which you would put your trust in an omniscient, apperceptive, and ultra-intelligent robotic therapist? There is a horizon beyond which we can neither see nor even imagine; this is the technological singularity moment for psychotherapy. If human intelligence is capable of creating an artificial intelligence that surpasses its creators, then this intelligence would, in turn, be able to create an even superior next-generation intelligence. An inevitable positive feedback loop would lead to an exponential intelligence growth rate. In the present paper, we introduce the term Therapist Panoptes as a working hypothesis to investigate the implications for psychotherapy of an artificial therapeutic agent: one that is able to access all available data for a potential client and process these with an inconceivably superior intelligence. Although this opens a new perspective on the future of psychotherapy, the sensitive dependence of complex techno-social systems on their initial conditions renders any prediction impossible. Artificial intelligence and humans form a bio-techno-social system, and the evolution of the participating actors in this complex super-organism depends upon their individual action, as well as upon each actor being a coevolving part of a self-organized whole.
Selection and regeneration of purple sweet potato calli against drought stress simulated by polyethylene glycol
Authors: Sunaryo Widi , Darnaningsih Darnaningsih , Nurhasanah Nurhasanah
Published: March 2019

Background: Water shortage due to natural and/or technical drought stress, widespread throughout Sumatra, Java, Sulawesi and Kalimantan islands, significantly reduces crop production. The development of varieties tolerant to drought stress is important since it is more effective rather than improving irrigation infrastructure to increase the sweet potato productivity.

Methods: Selection and regeneration experiments assessing purple sweet potato callus tolerance of drought stress, simulated by polyethylene glycol (PEG), were conducted to generate new variant plants tolerant of drought stress. Sterile explants (leaf and petiole) generated from previous in vitro culture were inoculated to the Murishage and Skoog (MS) medium containing plant growth regulator combination as treatments to induce calli. The calli were then transferred to half-MS medium containing 0, 5, 10, 15 and 20% PEG as selection agent for drought tolerance. The surviving calli were regenerated in the MS medium containing 0, 0.5, 1 or 1.5 mg l-1 6-benzylaminopurine (BAP). The callus formation, growth and survivability during in vitro culture were measured.

Results: Calli were successfully formed in almost all media containing 2,4-Dichlorophenoxyacetic acid (2,4-D ) with the concentration of 1, 2, 3 and 4 mg l-1 and BAP (concentration: 0.5 and 1 mg l-1), but the medium of MS + 2 mg l-1 2,4-D + 0.5 mg l-1 BAP resulted in the highest number of induced calli per treatment (mean=11.36), with the percentage of responsive explants standing at around 96%. The higher the concentration of PEG, the lower the number of surviving calli. At 20% PEG, only 54.42% calli survived. There were five plants successfully regenerated from the survived calli at 20% PEG, using MS medium containing 1.5 mg l-1 BAP.

Conclusions: The experiment has successfully produced putative drought-tolerant plants by callus screening using PEG as drought-tolerance-selecting agent in purple sweet potato.
Comparing simulated client experiences with phone survey self-reports for measuring the quality of family planning counseling: The case of depot medroxyprogesterone acetate – subcutaneous (DMPA-SC) in Nigeria
Authors: Diamond-Smith Nadia , Treleaven Emily , Omoluabi Elizabeth , Liu Jenny
Published: March 2019

Background: The quality of family planning services can have important implications for uptake and continued method use. The aim of this analysis is to examine aspects of quality for a new injectable contraceptive method, DMPA-SC (depot medroxyprogesterone acetate – subcutaneous, known as Sayana Press®), service provision and contraceptive services more broadly in Nigeria.

Methods: We compared self-reports from follow-up phone surveys with users to simulated client interactions that were designed to measure the same concepts. Through mixed-methods, we sought to more deeply understand the biases associated with different data collection methods that ultimately lead to different conclusions regarding quality of contraceptive services, and to further assess to what extent these methods were suitable for detecting differences in quality across sub-groups using the case of married versus unmarried women.

Results: We found that simulated clients reported lower levels of quality across all comparable quality indicators than phone survey respondents attending the same facilities. Both methods were able to detect differential treatment by marital status.

Conclusions: A mixed-methods approach can provide differential insights into quality of family planning services, especially when aiming to understand both objective and subjective aspects of quality.
Práticas sustentáveis: adoção de cultura institucional em IES
Authors: Zeitone Bruno , Trigo José Aires , Trigo Aline , Maruyama Úrsula
Published: March 2019

As Instituições de Ensino Superior (IES) têm um papel relevante no despertar da consciência ambiental e formação de um pensamento crítico dos futuros profissionais, a fim de propiciar um ambiente adequado ao desenvolvimento de uma realidade sustentável e de que os alunos se constituam sujeitos coletivos e voltados à participação efetiva nos processos sociais. Nesse sentido, o presente estudo tem como objetivo demonstrar a importância do desenvolvimento de práticas e iniciativas sustentáveis nas Instituições de Ensino Superior, investigando a gestão com responsabilidade socioambiental, através de disciplinas e projetos, que tratem da temática da sustentabilidade dentro da instituição de ensino em questão. Ao incentivar projetos e práticas sustentáveis que colaborem com a educação ambiental, as IES poderão contribuir para a formação de um novo modelo de cultura institucional, que se baseia na mudança do comportamento de indivíduos de uma comunidade frente ao uso dos recursos ambientais.
ELABORAÇÃO DE ESCORE DE RISCO PARA RASTREAMENTO DE DOENÇA CELÍACA
Authors: Igarsaba Luiza Arregui , De Oliveira Mônica Maria Celestina , Vinholes Daniele Botelho
Published: March 2019

Objetivo: O objetivo deste estudo é elaborar um escore de risco que auxilie no rastreamento de doença celíaca, baseado nos fatores de risco já descritos na literatura. Metodologia: Trata-se de um estudo caso-controle com dois grupos: indivíduos que referem ter doença celíaca e indivíduos que referem não ter doença celíaca. Para a coleta de dados foi elaborado um questionário com base na revisão bibliográfica, respondido de forma online pelos participantes da pesquisa. Os dados coletados foram digitados no programa Excel e analisados no programa SPSS 23.0. Resultados: Dentre estes questionários, 72 eram casos (com doença celíaca) e 54 controles (sem doença celíaca). Houve diferença significativa, com valor-p de 0,005, entre os resultados dos escores médios do grupo de casos, 7,09 (desvio padrão: 1,47), e do grupo de controle, 4,59 (desvio padrão: 1,94). Discussão: O principal benefício esperado é que, com mais estudos, o doente celíaco possa iniciar o tratamento precocemente, reduzindo o risco de complicações e de comorbidades associadas, além de reduzir o índice de morte de doentes celíacos não diagnosticados ou com diagnóstico tardio. Conclusão: Conclui-se que existe uma diferença significativa entre os escores médios, mostrando que os casos possuem um maior escore em relação aos controles. É importante deixar claro que esse escore será usado apenas para fins de estudo de rastreamento e não para diagnóstico de doença celíaca.
PERCEPÇÕES DE DOENTES CELÍACOS SOBRE AS CONSEQUÊNCIAS CLÍNICAS E SOCIAIS DE UM POSSÍVEL DIAGNÓSTICO TARDIO NA DOENÇA CELÍACA
Authors: Santos Andressa Singolani dos , Ribeiro Cilene Da Silva Gomes
Published: March 2019

O objetivo deste estudo foi identificar percepções em relação às consequências clínicas e emocionais dos possíveis diagnósticos tardios da doença celíaca. O modo como o celíaco se vê enquanto doente, seus sentimentos quanto aos novos hábitos alimentares e sociais, a visão e comportamento da sociedade diante de sua comorbidade, bem como os sintomas clínicos sofridos pelo corpo, se refletem no seu estado clínico e emocional. Foram entrevistadas exclusivamente doentes celíacas do sexo feminino, sendo todas frequentadoras de reuniões da Associação de Celíacos do Estado do Paraná (ACELPAR), com base em um roteiro semiestruturado. A pesquisa, de cunho quanti-qualitativa, teve sua análise realizada através do conteúdo, e seus resultados retratam que 77% dos participantes consideraram seu diagnóstico tardio, sendo que dos mesmos, 38% declararam que os sintomas clínicos da doença surgiram na infância. O conhecimento produzido a partir deste estudo pode conscientizar profissionais e a sociedade sobre as consequências clínicas e sociais geradas pelo diagnóstico tardio da doença celíaca no corpo que já sofre, transmitindo suporte e compreensão.DOI: 10.12957/demetra.2019.33310
ESTIMATIVA DO PADRÃO ALIMENTAR DE ESTUDANTES DE NUTRIÇÃO DE UMA UNIVERSIDADE ESTADUAL DO RIO DE JANEIRO, BRASIL
Authors: Lanzillotti Haydée Serrão , Barros Maria Elisa , Jesus Leticia Da Silva , Marchitto Rebeca Regly , Portella Emilson Souza , Soares Eliane Abreu
Published: March 2019

Objetivo: verificar o padrão alimentar de um grupo específico de acadêmicas de Nutrição pautado nos pressupostos de uma alimentação saudável. Metodologia: Análise documental utilizando registros alimentares de acadêmicos de Nutrição, período 1994-2009. Mineração dos dados e aplicação do método para estimativa da contribuição energética. Teste de normalidade de Shapiro-Wilk. Determinação do valor energético utilizando tabelas de composição nutricional e rotulagem de alimentos. Classificação dos alimentos/bebidas em ordem decrescente nos percentis 75, 50 e 25. O padrão alimentar foi sustentado pela classificação da NOVA. Resultados: Participaram 671 acadêmicas, totalizando 1.342 registros, tendo sido declarados 240 alimentos/bebidas. A maioria das porções alimentares não apresentou comportamento gaussiano. Mediana representou a quantidade consumida. Padrão alimentar desenhado com alimentos/bebidas estimados por contribuição energética percentual (³ P 75, 0,0588%), captando-se 62 no total. Conclusão: O consumo alimentar das acadêmicas de Nutrição está centrado em alimentos in natura/minimamente processados, à exceção da ausência de hortaliças, sem deixar de abrir espaço para o consumo de processados e ultraprocessados.DOI: 10.12957/demetra.2019.35717
Representações sociais da morte para pessoas que vivem com HIV/AIDS
Authors: Gomes Antonio Marcos Tosoli , Santos Ana Dulce Santana dos , Maques Sérgio Corrêa , Nogueira Virgínia Paiva Figueiredo , Paula Glaudston Silva de , Vargens Octavio Muniz da Costa
Published: March 2019

Objetivo: descrever os conteúdos e a organização das representações sociais da morte para pessoas que vivem com HIV/AIDS. Método: estudo descritivo, exploratório, de abordagem qualitativa, e delineado por meio da Teoria das Representações Sociais. Participaram, 165 pessoas vivendo com HIV/AIDS, em tratamento no ambulatório de referência na cidade do Rio de Janeiro, aprovado com parecer número 699.220. Utilizou-se o software Evoc, ao final construiu-se o quadro de quatro casas. Resultados: abalizam uma dimensão emocional e do conhecimento das representações da morte, como um objeto multifacetado com diversos significados e variados sentimentos, apontando para a naturalização da morte. Conclusão: ainda que a morte contenha uma representação negativa, em pessoas com HIV/AIDS, pelos sentimentos ligados a tristeza, medo e dor, as estratégias políticas e governamentais, medidas de prevenção e tratamento no controle da doença delineiam uma nova direção, diante da cronicidade da síndrome, resultando em representações imbricadas no sentido da vida, do viver e do morrer como processo natural.
Demandas de idosos hospitalizados pós-correção de fratura de fêmur proximal por queda
Authors: Jacobi Caren Da Silva , Beuter Margrid , Venturini Larissa , Benetti Eliane Raquel Rieth , Bruinsma Jamile Laís , Santos Naiana Oliveira dos
Published: March 2019

Objetivo: conhecer as demandas dos idosos hospitalizados pós-correção de fratura de fêmur proximal por queda e de seus acompanhantes e realizar ações de educação em saúde. Método: pesquisa convergente assistencial, realizada de janeiro a dezembro de 2016, com 102 idosos hospitalizados pós-correção de fratura de fêmur proximal por queda e seus acompanhantes. Produziram-se os dados por meio de entrevista conversação e observação participante. Resultados: os idosos e acompanhantes manifestaram dúvidas e receio sobre mobilização, restrições de movimentos, uso e obtenção de andador e revelaram a necessidade de receber orientações dos profissionais sobre modificações na residência e prevenção de novas quedas. Conclusão: Com a problematização e diálogo estabelecido, eles puderam expor suas necessidades e refletirem possíveis estratégias para solucionar ou minimizar suas demandas. O envolvimento dos idosos e acompanhantes nas ações educativas é importante para um cuidado condizente com necessidades e realidade vivenciada.
Raciocínio clínico do enfermeiro: uma abordagem segundo a teoria do processo dual
Authors: Quaresma Adrieli , Xavier Daiani Modernel , Cezar-Vaz Marta Regina
Published: March 2019

Objetivo: refletir acerca do raciocínio clínico do enfermeiro na perspectiva da Teoria do Processo Dual. Conteúdo: trata-se de um estudo teórico-reflexivo construído, a partir da leitura crítica da Teoria do Processo Dual e de artigos científicos acerca do raciocínio clínico em enfermagem, buscados na Biblioteca Virtual em Saúde e Pubmed. O raciocínio clínico é composto por dois sistemas de processamento de informações que possibilitam a tomada de decisões em um contexto clínico. Constitui base para o desenvolvimento do processo de enfermagem e gerência do cuidado. Ademais, favorece identidade, visibilidade e confiabilidade da enfermagem como profissão da área da saúde, ao proporcionar a ruptura com a prática do cuidado mecanizado, tornando-o algo pensado e sustentado por conhecimentos científicos. Conclusão: este estudo permitiu a reflexão acerca do raciocínio clínico do enfermeiro na perspectiva da Teoria do Processo Dual. Espera-se subsidiar ações de desenvolvimento e aprimoramento dessa habilidade na assistência e no ensino.
Preparo de alta para o cuidado domiciliar de recém-nascidos de baixo risco
Authors: Duarte Fernanda Carla Pereira , Góes Fernanda Garcia Bezerra , Rocha Andrea Lyra Arnozo da , Ferraz Joana De Andrade Nobre , Moraes Juliana Rezende Montenegro Medeiros de , Silva Liliane Faria da
Published: March 2019

Objetivo: analisar o preparo de alta de famílias no Alojamento Conjunto quanto aos cuidados domiciliares dos recém-nascidos. Método: pesquisa qualitativa, desenvolvida através de Dinâmicas de Criatividade e Sensibilidade Corpo Saber, do Método Criativo Sensível, junto a dezessete participantes, entre puérperas e familiares, no Alojamento Conjunto de um hospital municipal da baixada litorânea do Rio de Janeiro, cujos dados foram submetidos à análise temática. Resultados: o preparo de alta abarca orientações principalmente sobre aleitamento materno e manejo do coto umbilical, mas incluem conteúdos sobre banho, posições confortáveis e vacinas. As enfermeiras assumem o papel social de educadoras, por meio de uma prática educativa pontual baseada na transmissão de informações e na demonstração do cuidado do recém-nascido.  Conclusão: existem lacunas no preparo de alta quanto às orientações essenciais para o cuidado domiciliar do recém-nascido com segurança e qualidade, ademais, é preciso buscar abordagens pedagógicas dialógicas que partam da realidade das famílias.
Understanding the foot's functional anatomy in physiological and pathological conditions: The calcaneopedal unit concept
Authors: Ghanem I. , Massaad A. , Assi A. , Rizkallah M. , Bizdikian A. J. , El Abiad R. , Seringe R. , Mosca V. , Wicart P.
Published: March 2019

Background

A thorough review of the available orthopaedic literature shows significant controversies, inconsistencies and sparse data regarding the terminology used to describe foot deformities. This lack of consensus on terminology creates confusion in professional discussions of foot anatomy, pathoanatomy and treatment of deformities. The controversies apply to joint movements as well as static relationships between the bones.

Description

The calcaneopedal unit (CPU) is a specific anatomical and physiological entity, represented by the entire foot excepted the talus. The calcaneus, midfoot and forefoot are solidly bound by three strong ligaments that create a unit that articulates with the talus. The movement of the CPU is complex, as it rotates under the talus, around the axis of Henke that coincides with the talo-calcaneal ligament of Farabeuf. This calcaneopedal unit is deformable. It is compared with a twisted plate, able to adapt to many physiological situations in standing position, in order to acheive a plantigrade position. Moreover, the calcaneopedal unit and the talo-tibiofibular complex are interdependent; rotation of the latter produces morphologic modifications inside the former and vice versa.

Purpose

This paper is a review article of this concept and of its physiopathological applications.
‘It’s just houses’: the role of community space in a new housing development in the digital era
Authors: Jacklin-Jarvis Carol , Cole Marion
Published: March 2019

This paper explores the role played by social media and physical community space in creating community identity in a new residential area. It argues that physical space still matters in a digital era, as social media tends to draw similar people together, rather than building bridges between diverse groups of residents. To build community identity that is both cohesive and inclusive, it is important that community space is available from early on in a building programme.
Adaptive Behavior and Intelligence in Adolescents With Down Syndrome: An Exploratory Investigation
Authors: Sabat Camila , Tassé Marc , Tenorio Marcela
Published: March 2019

Down syndrome (DS) is characterized by difficulties in both intellectual functioning and adaptive behavior. These sets of abilities are considered as separate but related domains with small to moderate correlations. The main objective of this study was to explore the relationship of intellectual functioning and adaptive behavior in adolescents with DS because previous studies have shown different relationship patterns between these constructs across other syndromes. Fifty-three adolescents with DS were assessed regarding their intellectual functioning whereas adaptive behavior was reported by parents and teachers. Participants showed a better performance on verbal than nonverbal tasks when assessing intellectual functioning, contrary to previous findings. Regarding adaptive behavior, higher social skills were reported than conceptual and practical skills. Intellectual functioning and adaptive behavior showed a medium correlation, consistent with observations in typical population. These results support the exploration of the variability across the DS phenotype.
Latrophilin2 is involved in neural crest cell migration and placode patterning in Xenopus laevis
Authors: Yokote Natsumi , Suzuki-Kosaka Marianna Y. , Michiue Tatsuo , Hara Takahiko , Tanegashima Kosuke
Published: March 2019

Latrophilin2 (Lphn2) is an adhesion-class of G protein-coupled receptor with an unknown function in development. Here, we show that Xenopus laevis lphn2 (Xlphn2) is involved in the migration and differentiation of neural crest (NC) cells and placode patterning in Xenopus laevis embryos. Although Xlphn2 mRNA was detected throughout embryogenesis, it was expressed more abundantly in the placode region. Morpholino antisense oligonucleotide-mediated knockdown of Xlphn2 caused abnormal migration of NC cells, irregular epibranchial placode segmentation, and defective cartilage formation. Transplantation of fluorescently-labeled NC regions of wild-type embryos into Xlphn2 morpholino-injected embryos reproduced the defective NC cell migration, indicating that Xlphn2 regulates the migration of NC cells in a non-cell autonomous manner. Our results suggest that Xlphn2 is essential for placode patterning and as a guidance molecule for NC cells.
Evidence for an evolutionary relationship between Vmp1 and bacterial DedA proteins
Authors: Tábara Luis-Carlos , Vincent Olivier , Escalante Ricardo
Published: March 2019

VMP1 and DedA proteins are conserved families of transmembrane proteins in eukaryotes and prokaryotes respectively. Despite numerous reports involving these proteins in multiple cellular processes, their molecular function is still unknown. They share the domain of unknown function PF09335, suggesting a possible functional relationship between these protein families. Here we show that VMP1 from different species contain two short motifs conserved in the bacterial DedA proteins and the yeast protein Tvp38. The hallmark of one of these motifs is a glycine residue previously shown to be strictly conserved in all the DedA proteins. Substitution of this residue to leucine, glutamate or arginine in Dictyostelium Vmp1 inactivates the protein, as shown by the inability of the mutants to rescue the phenotypes associated with the lack of Vmp1 including development and lipid homeostasis. This is the first experimental approach that supports an evolutionary relationship between Vmp1 and DedA proteins and highlights the importance of the conserved glycine residue in the PF09335 domain.
On the biomechanical properties of osteosarcoma cells and their environment
Authors: Müller Daniel A. , Silvan Unai
Published: March 2019

Although rare among the general population, bone malignancies have a high rate of incidence among children and adolescents and are associated with high mortality rates. Osteosarcoma (also known as osteogenic sarcoma) is the most frequent primary cancer of bone and shows a high tendency to metastasize to the lung. Despite the frequent use of osteosarcoma-derived cell lines in basic biomechanical research and for the evaluation of cell responses to new biomaterials, the mechanical phenotype and the differences between osteosarcoma cells and related cell types, such as mesenchymal cells, osteoblasts and osteocytes, remain largely unknown. In the present review we summarize current knowledge of the biophysical and mechanical properties of the niche of primary osteosarcomas and of the malignant cells, and discuss the impact of these features on the progression of malignancy.
O tempo de exceção do riso no reisado: a cartografia da performance de brincantes transviados e o terreiro do mestre como espaço educativo
Authors: Oliveira Ribamar José de , Fortes Lore
Published: March 2019

A partir do pensamento de Albuquerque Junior (2013) sobre a comemoração como a experiência de um tempo fronteiriço e diante das reflexões de Barroso (2018) sobre o riso do brincante nas cenas de Reisado nordestino, o trabalho propõe realizar uma cartografia da performance de pessoas LGBTT+ nos grupos de Reisado do Congo em Juazeiro do Norte, interior do Ceará, para pensar a construção do território existencial no plano cartográfico (ALVAREZ; PASSOS; 2009) como espaço educativo na tessitura da cultura popular na região do Cariri cearense.
DESIGUALDADE DE GÊNERO E ALTAS HABILIDADES/SUPERDOTAÇÃO
Authors: Neumann Patricia
Published: March 2019

Gênero e altas habilidades/superdotação são temas contemporâneos na educação e sociedade. Assim, o objetivo foi analisar artigos sobre ambos. O método foi bibliográfico. A fonte foi o Google Acadêmico e a análise qualitativa. Os resultados foram 4 artigos com diferentes objetos e métodos, mas com um ponto comum: há menos meninas identificadas com superdotação e menos mulheres na ciência. Isto aponta para a desigualdade de gênero, a qual é influenciada pela heteronormatividade e mitos pautados numa ideia específica de racionalidade. Considera-se que a diversidade de pesquisas é positiva, mas há imensa falta de estudos sobre as identidades de gênero e superdotação.
Ah, é amor!?
Authors: Silveira VERÔNICA Canteiro
Published: March 2019

O relato trata de atividades realizadas em turmas do ensino fundamental - anos finais- sobre os relacionamentos abusivos.