bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovative development of a credit market
Authors:   Uman national university of horticulture, Bechko P. K. , Bondarenko N. V. , Bechko V. P. , Natalych O. S.
Published: June 2021

Various processes of transformation of the national economy, which are a necessary prerequisite for the formation of a new economic model using digital and cognitive technologies, were researched in the article. State support for the integration of the credit market into the innovation process, which should be considered as a system of measures providing regulatory support for credit institutions was studied. The innovative development of the domestic economy was investigated, and it was found that it largely depended on the development of the credit market. It was determined that the initiators of the innovation process should be banks, as they should stimulate the launch and development of innovative projects of their corporate clients. It was studied that the participants of the credit market used innovative technologies and as a result of which transaction costs were reduced. Banking services for different groups of clients became more accessible, and banking services became differentiated, and as a result of which the profitability of the banking business increased due to obtaining of higher commission income. It was defined that the NBU participated in the creation of technologies and platforms for improving the efficiency of credit market regulation and inspection, as well as providing all market participants with equal secure access to information necessary to comply with modern high standards of banking activity. Despite the fact that the activity of the NBU on the formation a digital space of financial and credit markets, of course, deserves the most positive estimation, it should be noted that this activity are limited by individual decisions in the absence of a systematic approach. It is necessary that the ecosystem of the credit market will be integrated with the ecosystems of the largest domestic banks, as well as with the platforms of other credit institutions. It is noted that the further development of the innovative component of the credit market is contained in the creation of the conditions stimulating more active participation of banks in the implementation of projects aimed at modernization and innovative development of the national economy. Banks, applying an innovative approach to work with clients, must not only take into account but also anticipate the requests of different customer groups. Innovations are the part of the business model for banks. They connect the prospects of their own development to the needs of the client groups of new generations.
THEORETICAL ASPECTS OF HARMONIZATION OF UKRAINIAN TAX SYSTEM IN CONTEXT OF BEHAVIORAL FINANCE
Authors:   Uman national university of horticulture, Barabash L. V.
Published: June 2021

The tax system of Ukraine in the way in which it now operates, in terms of performance does not meet the conditions of modern tax systems of the world's leading countries. Proof of this is 84th place in the ranking of competitiveness and 23rd place in the ranking of the Top 25 countries with the highest level of taxation. Therefore, harmonization of the tax system is needed to simplify tax treatment and reduce the tax burden or average it in order to reduce the prices of goods production means. It is noteworthy that harmonization is now considered primarily as the harmonization of the standards of the tax systems of different countries in the framework of cooperation and the achievement of mutual positive effects. However, each state has its own economic traits and national traditions, which are reflected in the functioning of taxes. Therefore, harmonization, as a phenomenon of an economic nature, is quite applicable within a particular tax system. Among plenty of factors influencing the operating of the tax system, a group of behavioral aspects is relatively new for the native economic environment. They are based on the habits, traditions and culture of the population, public consciousness and the level of psychological and social tension in society. Although it is notable that behavioral factors arise and worsen under the influence of other groups of parameters. And one of these is the level of fiscalization of the economy and its basis - the tax system. The high level of fiscalization of the tax system has formed a negative attitude of taxpayers to taxation, which has intensified the shadow trends in the state economy. The inconsistency between the amounts of taxes paid and the quality and amount of services and benefits received from the state, as well as the low level of social guarantees, caused a general cognitive dissonance. Transformed into a prejudice, he acquired a national social character, forming a model of economic behavior that in fact denies the defining role of the state in the life of the modern individual. Therefore, it should be emphasized that the harmonious functioning of the tax system should be based on a comprehensive approach, taking into account various factors. And from this point of view, behavioral finance becomes a factor of core and direct influence.
Tourist zoning of the territory of Cherkasy region
Authors:   Uman national university of horticulture, Neshchadym L. N. , Tymchuk S. V. , Tereshchuk N. V.
Published: June 2021

The constant growth of the popularity of tourism in Ukraine and the world, the intensification of entrepreneurial activity in this area make tourism one of the most promising sectors of the economy. Modern processes of transformation in the economic complex and the service sector cause profound changes, requiring a new look at all manifestations of socio-economic activity of society. The leading place is given to the balanced and efficient use of local recreational resources. Given this, in those regions that have natural and recreational potential and have a positive ecological status, special importance is attached to the further development and improvement of tourism and recreation of the region. Cherkasy region has all the opportunities to become one of the main tourist regions due to its natural-recreational and historical-cultural potential. Cherkasy region has a well-developed infrastructure, active tourist flows and a rich historical heritage. All this, combined with recreational and social conditions, contributes to the intensive development of tourism business in the region. It should be noted that the intensity of tourism today does not directly depend on the recreational base of region, but on quality of relevant resources and modern infrastructure. Recreational zoning of Cherkasy territory should be carried out in order to determine the most promising and cost-effective areas of investment and systematization of future costs. It is important to pay attention to the organization of clusters in the tourist zoning of Cherkasy region. It should be noted that the cluster effect is created due to the synergistic effect. The synergetic effect provides an increase in efficiency as a result of integration, the merging of individual parts into a single system by creating a systemic effect. Synergism means the excess of the sum of the factors that make it up. The synergistic effect provides an opportunity to solve the problems of the relationship between different activities of one or more entities to achieve higher results than in the case of autonomous actions for each activity of each enterprise that operates in a particular group of enterprises. Optimization due to the interaction of all activities on the basis of the synergetic effect is strategic in nature, because it provides advantages over other entities. Thus, we can conclude that Cherkasy region has objective prerequisites for tourism development. Certain shortcomings of modern territories are an obstacle to tourism development, but they cannot be interpreted as impeding the development of the industry in the region
Aggressive tax planning
Authors:   Uman national university of horticulture, Nepochatenko O. O. , Bechko P. K. , Bechko V. P. , Ptashnyk S. A.
Published: June 2021

The article forms and systematizes the author's approach to the legislative enshrinement in the Tax Code of Ukraine of the essence of economic categories "aggressive tax planning", "minimization of tax liabilities". These terms are widely used in the practice of the OECD and countries with developed market relations. The article highlights the results of the work of the 10th OECD Working Group on Aggressive Tax Planning and the OECD Forum on Tax Administration. Generalized issues regarding the inconsistency of the tax base, which allows taxpayers to minimize and evade their payment. Methodological and theoretical foundations of the study are economic theory, scientific developments of foreign and domestic scientists on the problems of aggressive tax planning. The following research methods were used in the research process: abstract –logical, comparison, monographic and scientific generalization. Studies show that aggressive tax planning as a relatively new category still requires painstaking improvements from those international structures that have sponsored it. Note that the OECD has proposed two somewhat vague definitions of aggressive tax planning that have already been criticized by experts. Thus, according to one definition, it is planning that includes a tax position that is rational, but leads to a result that is unpredictable for the tax authorities, given its inconsistency with the purpose of the law. The experience of foreign countries in identifying and regulating aggressive tax planning should be adapted to domestic realities and reflected in the tax system at the legislative level, which will help improve tax administration, support big business, solve investment, innovation and social problems. The results of the study show that the management of any socially important process requires the ability to constantly maneuver in a large number of changes and new opportunities. The OECD's experience shows that responding to new taxpayer schemes for aggressive tax planning is a challenge. With the enactment of legislation to counter aggressive planning to eliminate them from tax practice, taxpayers are finding new, more sophisticated methods, using them to minimize tax liabilities. This struggle between the two subjects of tax relations will continue as long as the states function mainly through taxes and other obligatory payments.
Exploring Teachers’ Perceptions in Managing Interracial Interactions in a Multicultural setting: A Case study of Five Malaysian Secondary Schools in Klang Valley
Authors: Othman Azam , Sheikh Ahmad Ismail , Abdul Rahman Hamidon , Fhaizal Shabu Shahrul
Published: June 2021

The multicultural school environment at the Malaysian national schools presents a number of issues and challenges for the in-service teachers. This study investigated the experiences of 16 teachers in five selected national type schools in Klang Valley. Through a series of semi-structured interviews, responses from the teachers provided insights to the multiculturalism school environment in a multiracial society such as Malaysia. The findings of this study revealed that low proficiency of the national language among non-Malay students, inadequate multicultural trainings for teachers, and lack of programmes and initiatives that promote unity in a multicultural environment are among the major hurdles faced by teachers. The implications of the findings and recommendations from the teachers on ways to improve the multicultural environment in schools are also presented.

 

Abstrak

 

Persekitaran sekolah kebangsaan yang majmuk budaya di Malaysia menampilkan beberapa isu dan cabaran bagi guru-guru dalam perkhidmatan.  Kajian ini menyelidik pengalaman 16 orang guru daripada lima buah sekolah jenis kebangsaan yang dipilih di sekitar Lembah Klang.  Respons daripada para guru melalui satu siri temubual separa berstruktur, memberi maklumat lebih dalam tentang persekitaran sekolah majmuk budaya dalam masyarakat majmuk seperti Malaysia.  Hasil kajian mendapati penguasaan Bahasa kebangsaan yang rendah dalam kalangan pelajar bukan Melayu, kekurangan latihan tentang kemajmukan budaya dalam kalangan guru dan kekurangan program dan inisiatif bagi memajukan perpaduan kaum dalam persekitaran majmuk budaya merupakan beberapa halangan utama yang dihadapi oleh guru. Kertas ini turut membentangkan implikasi bagi dapatan kajian dan mengesyorkan beberapa saranan daripada para guru tentang cara untuk menambahbaik persekitaran majmuk budaya di sekolah.

Kata kunci: pendidikan majmuk budaya; kemajmukan budaya di Malaysia; sekolah di Malaysia; pengalaman guru tentang kepelbagaian bangsa.
Üniversite Öğrencilerinin Bilinçli Farkındalıkları ile Bilişsel Esneklikleri Arasındaki İlişki
Authors: Peker Akman Tuğçe , Demir Melek
Published: June 2021

Bu çalışmanın amacı, üniversite öğrencilerinin bilinçli farkındalıkları ile bilişsel esneklikleri arasındaki ilişkiyi incelemektir. Bu araştırmanın çalışma grubunu 187 kadın ve 57 erkek toplam 244 üniversite öğrencisi oluşturmaktadır. Çalışma grubundaki üniversite öğrencilerinin yaşları 18 ile 34 arasında değişmekte olup, yaş ortalaması 20.27’dir. Veri toplama sürecinde Bilinçli Farkındalık Ölçeği, Bilişsel Esneklik Envanteri ve katılımcıların demografik bilgilerinin toplandığı kişisel bilgi formu kullanılmıştır. Bilinçli farkındalık ile bilişsel esneklik (alternatif ve kontrol) arasındaki ilişkileri belirlemek amacıyla Pearson momentler çarpımı korelasyon katsayıları kullanılmıştır. Korelasyon analizi sonuçlarına göre, bilinçli farkındalık ile bilişsel esneklik ve bilişsel esnekliğin alt boyutları olan alternatif ve kontrol arasında pozitif yönde anlamlı ilişkiler tespit edilmiştir. Bilinçli farkındalık ile bilişsel esneklik arasındaki ilişkinin cinsiyete göre anlamlı bir farklılık oluşturup oluşturmadığını belirlemek amacıyla Çok değişkenli varyans analizi (MANOVA) kullanılmıştır. Manova testi sonuçlarına göre cinsiyetin bilinçli farkındalık ile bilişsel esneklik arasındaki ilişkide anlamlı bir etkisinin olduğu belirlenmiştir. Bilinçli farkındalığın bilişsel esnekliği ne derece yordadığını belirlemek amacıyla Basit doğrusal regresyon analizi yapılmıştır. Regresyon analizi sonucunda bilinçli farkındalığın bilişsel esnekliğin toplam varyansının % 29.4’ünü açıkladığı sonucuna ulaşılmıştır. Araştırma sonuçları ışığında, rehberlik ve psikolojik danışmanlık alanında gerçekleştirilen etkinliklerde bilinçli farkındalık ve bilişsel esnekliğin geliştirilmesine yönelik psikoeğitim programları hazırlanabilir.
Child marriage briefing: Mali
Authors:   Population Council
Published: June 2021

This brief provides an overview of child marriage as well as the particulars of child marriage in Mali. Mali is home to 11.6 million people, with 47 percent of its population under age 15. Approximately 73 percent of the population live on less than US$1 a day, and life expectancy is 45 years. Mali has one of the most severe crises of child marriage in the world today. The legal age of marriage is 18 for girls and 21 for boys, but girls may be married as early as age 15 with parental consent. For civil marriages, the law dictates that prospective spouses discuss and agree on whether their union will be polygynous or monogamous; however, a woman’s say in the matter is minimal given her limited options. The payment of bride price is recognized by law, promoting the perception that wives are the property of husbands. In addition, female genital circumcision affects nearly all Malian women, with 61 percent of circumcisions occurring before age 5. Included in this brief are recommendations to promote later, chosen, and legal marriage.
Pengukuran Nilai Grounding Terbaik Pada Kondisi Tanah Berbeda
Authors: Arifin Jaenal
Published: June 2021

Sistem pentanahan atau grounding  yang baik diharapkan dapat melindungi perangkat elektronika, baik secara langsung ataupun secara tidak langsung jika terjadi sambaran petir saat terjadi hujan. Karakteristik dan kondisi tanah merupakan salah satu faktor yang dapat mempengaruhi nilai pentanahan atau grounding. Pada penelitian ini dilakukan kegiatan pengukuran pentanahan atau grounding pada kondisi tanah berbeda, yaitu pada kondisi tanah berair atau tanah liat, tanah kering, tanah berbatu, tanah pasir dan tanah rawa. Penelitian ini bertujuan untuk mengetahui besarnya tahanan pentanahan atau grounding. Metode pengukuran menggunakan tiga titik (three point methode) dan empat titik (four electrode methode) dengan menancapkan elektroda batang ke dalam tanah. Nilai resistansi tahanan yang tertampil pada alat ukur (Earth Resistance Tester) akan semakin kecil jika penanaman elektroda ditanam lebih dalam dan adanya penambahan batang elektroda, serta jarak antar elektroda diatur 5 sampai 10 meter.
Perancangan Lapis Pondasi Agregat Tanpa Penutup Aspal Pada Gradasi Batas Tengah Dengan Menggunakan Clay Stone
Authors: Norhadi Ahmad , Fauzi H. Muhammad , Marzuki Akhmad , Zuraida Zuraida
Published: June 2021

“Lapis Pondasi Agregat tanpa penutup aspal” is a strong layer structure because it receives a direct load of vehicles above the surface. In general, the making of access roads for mining sites does not use pavement with asphalt. One of the materials for mining pavement generally uses the mine's surface excavation using a clay stone as an addition to a mixture or filler for the aggregate layer structure. Clay stone is a sedimentary rock that is strong if it is in the soil and will become soft when submerged in water. “Lapis Pondasi Agregat tanpa penutup aspal” is dominated by fine particles which is a maximum diameter of 19 mm making it difficult to adjust the gradation composition. So to get the ideal gradation of “Lapis Pondasi Agregat tanpa penutup aspal” composition, it is necessary to do Research on “Lapis Pondasi Agregat tanpa penutup aspal” on Middle Border Gradations Using Clay Stone". The purpose of this study was to determine the value of the mixture composition between clay stone and broken stone, the value of PI content (plastic index) and CBR value

“Lapis Pondasi Agregat tanpa penutup aspal” must meet the requirements of material properties in accordance with the General Revised 3rd Edition of Bina Marga specifications, the gradation consists of material passed the filter ¾, maximum liquid limit value of 35%, minimum plasticity index value of 4% and maximum 15 %, clumps of clay and fragile granules of at least 0% and a maximum of 5%, coarse aggregate abrasion is a maximum of 40% and has a minimum CBR (California Bearing Ratio) value of 60%.

From the results of this study, it can be seen the mixture composition between clay stone and stone, PI value (plastic index) and CBR value from the gradation of the middle boundary of the “Lapis Pondasi Agregat tanpa penutup aspal”. The composition of the mixture of clay stone and aggregate rock broke on the middle boundary gradation, ie 1-2% broken stone by 20%, 1-1 broken stone by 33%, stone ash by 35%, and clay stone by 12%. Based on the results of the examination of the liquid limit and plastic limit, the Plastic Index (PI) value of the clay stone was 35.696% and for the combination of the mixture of broken stone with an additional 12% clay stone was 13.941%. Based on the results of laboratory density and CBR examinations, it was found that the design CBR value of broken stone aggregate was 73%, the clay stone was 1,150% and for the combination of clay stone and aggregate rock was broken by 64%.
KUALITAS LAPIS PONDASI ATAS KELAS A DENGAN MENGGUNAKAN MATERIAL BERASAL DARI KUARI BENTOK DAN AWANG BANGKAL SUATU STUDI KASUS
Authors: Rozi Fathur , Sukmawan Fajar
Published: June 2021

Uji Kualitas Material untuk pekerjaan Lapisan Pondasi Agregat Kelas A pada penulisan ini bermaksud untuk melakukan pengujian awal terhadap kualitas material Lapis Pondasi pada tumpukan material di stockpile pelaksanaan pekerjaan perkerasan jalan yang akan digelar di jalan Hercules Kecamatan Landasan Ulin Banjarbaru. Material  yang diuji berasal dari kuari Bentok dan material dari kuari Awang Bangkal dengan tujuan ingin mengetahui apakah produk Lapis Pondasi Agregat yang dihasilkan dari  kedua sumber material ini dapat memenuhi dan berkesesuaian dengan syarat standard spesifikasi Bina Marga. Metode yang digunakan dalam pengujian ini yakni dengan mengambil sampel material dari lapangan yang kemudian dilakukan pengujian di Laboratorium Politeknik Negeri Banjarmasin, dengan mengacu pada metode pengujian Standar Nasional Indonesia (SNI).

Dari hasil pemeriksaan dengan menggunakan material asal Bentok diperoleh nilai Berat Jenis Agregat Halus  2.594, Berat Jenis Agregat Kasar 2.663, Abrasi 30.38%  berat volume kering maksimum gabungan 2.178 gr/cm3 dan CBR Rendaman 4 hari 91%. Adapun hasil pemeriksaan dengan menggunakan material asal Awang Bangkal diperoleh nilai Berat Jenis Agregat Halus 2.611, Berat Jenis Agregat Kasar 2.6719, Abrasi 32.12%  berat volume kering maksimum gabungan 2.178 gr/cm3 dan CBR Rendaman 65 %. Syarat spesifikasi Bina Marga, CBR rencana minimum untuk Lapis Pondasi Agregat Kelas A adalah 90% dan nilai abrasi minimum adalah 40 %.
Model Kajian Implementasi Sistem Informasi Penelitian Dan Pengabdian Kepada Masyarakat Politeknik Negeri Banjarmasin
Authors: Rozaq Abdul , Hardinto Raden Kelik , Sholihin Fuad
Published: June 2021

Pusat Penelitian dan Pengabdian kepada Masyarakat (P3M) POLIBAN merupakan sebuah Pusat yang memiliki tugas dan fungsi mefasilitasi kegiatan penelitian dan pengabdian kepada masyarakat yang dilaksanakan oleh dosen di lingkungan Politeknik Negeri Banjarmasin. Mulai tahun 2018 data penelitian dan pengabdian kepada masyarakat pengelolaan dengan mengembangkan Sistem Informasi penelitian dan pengabdian kepada masyarakat (SIPMA). Pengelolaan data tersebut dimulai dari menentukan skema yang akan diberikan pendanaan yang di dalamnya sudah dijelaskan mulai dari ruang lingkup penelitian, jadwal pengajuan proposal, review proposal sampai dengan pelaksanaan dan pelaporan. Sedangkan untuk melihat tingkat keberhasilan implementasi SIPMA, P3M Poliban belum melakukan evaluasi implementasi SIPMA tersebut.

Berdasarkan permasalahan di atas, maka P3M Poliban membutuhkan sebuah kajian implementasi SIPMA, sehingga dapat diketahui tingkat keberhasilan dan kepuasan pengguna SIPMA. Penelitian ini menyebarkan alat ukur berupa kuesioner kepada pengguna SIPMA. Dimana dalam proses analisisnya digunakan kerangka kerja penerapan Partial Least Square (PLS) di dalam SEM yang merupakan sebuah model statistik yang memberikan perkiraan perhitungan dari kekuatan hubungan hipotesis di antara variabel dalam sebuah model teoritis.

Hasil dari penelitian menunjukan bahwa Kualitas Sistem berpengaruh signifikan terhadap Kepuasan Pengguna dengan T-statistik sebesar 3,107 (> 1,96). Kualitas Informasi berpengaruh signifikan terhadap Kepuasan Pengguna dengan T-statistik sebesar 2,215 (> 1,96). Kualitas Pelayanan berpengaruh signifikan terhadap Kepuasan Pengguna dengan T-statistik sebesar 2,909 (> 1,96). Kepuasan Pengguna berpengaruh signifikan terhadap Dampak Individual dengan T-statistik sebesar 15,652 (> 1,96). Dampak Individual berpengaruh signifikan terhadap Dampak Organisasi dengan T-statistik sebesar 10,410 (> 1,96).
Developing Critical Resilient Leadership Behavior Through Collaborative Management: A Logical Perspective
Authors: Buradum Tende Friday , Okebiobramama Lawson Abiye
Published: June 2021

This study attempts to understand how collaborative management could enhance and improve organizational leadership and elicit resilient behaviors. Thus, collaboration and resilience are basic characteristics that can help any organization surmount unpredictably challenging situations, and even thrive in the process. A systematic review was used in which relevant theories were examined in line with this objective. It was found that; cultivating, developing, and refining collaborative efforts in organizational leadership, employee-employer relationships, and organizational success are key factors in the pursuit and actualization of predetermined organizational objectives. This outcome demonstrates that leading successfully in an unpredictable and change-prone environment is a huge task. Hence, for organizational leadership to survive and thrive, it has to develop the capacity to be adaptive, swiftly recover from setbacks, maintain relatively stable and functional health, and harness all its resources to remain in business. Therefore, an organization that collaborates on several fronts will create a resilient spirit to face and surmount unpredictably challenging situations if/when they arise. Thus, organizations that intend to succeed in this regard must promote cohesion, diversity, interdependence, inclusion, and social support through enthusiastic and enterprising capabilities.
EFFECT OF AGE AND SEX ON MORPHOMETRIC MEASUREMENTS OF SAHELIAN GOATS IN FASKARI LOCAL GOVERNMENT AREA OF KATSINA STATE
Authors: Aliyu A. M. , Rotimi E. A. , Galadima N. M.
Published: June 2021

This research was conducted to determine the effect of age and sex on morphometric measurements and estimate correlation between body weights and morphological traits of Sahelian goat in Faskari Local Government Area, Katsina state. Experimental animals aged from 1-5 years were used for this study and were identified using physical appraisal. Physically healthy of both sexes and non-pregnant goats were sampled.  The pairs of permanent incisors in the dentition of the goat were used to determine age, body weight by using bathroom weighing scale (kg), linear measurements using flexible tailor’s measuring tape and sex using physical observations. The results obtained, showed that age had significant (P<0.05) effects on RH, EL, HoL and TL, non-significant (P˃ 0.05) effect was found on BW, NL and BL. Sex had significant effect on BW, BL, HG and HoL and non- significant effect (P˃ 0.05) was found on RH, EL, TL and NL. Correlation coefficient between body weight and linear measurement shows that BW was highly correlated (P<0.01) with BL, HG and NL. BW was slightly correlated with RH and it was negatively correlated EL and HoL.
Pulmonary and intranasal delivery of thymoquinone-loaded nanoparticles for Mucormycosis & Covid-19
Authors: Sommer Andrei , Försterling Horst-Dieter , Naber Kurt , Pitchappan Ramasamy
Published: June 2021

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India is currently reporting a massive increase of mucormycosis infection among Covid-19 patients. The opportunistic black fungus infection affects the lungs and the brain. Depending on the infected organs, morbidity and mortality rates are between 50% and 100%. To save patients’ life, it is frequently necessary to remove jaws and eyes. The drug of the first choice for the treatment of mucormycosis in the subcontinent is amphotericin B. There are two problems with amphotericin B: First, it is currently not available in many pharmacies in India, and second, its effect is restricted by its limited passage across the blood-brain barrier. Recently, it was shown that thymol is highly effective against Rhizopus oryzea, the fungus causing 70% of mucormycosis. In contrast to amphotericin B, which in the case of mucormycosis is administered intravenously, thymol can reach the lungs via inhalation and the brain via the nose-to-brain route. Importantly, thymoquinone (TQ) has all the relevant biological properties of thymol and has already been successfully used to treat Covid-19, as demonstrated in clinical studies. In addition to the action spectrum of thymol, TQ can act as a reactive oxygen species and oxidize pathogens upon contact, thereby recommending itself for both treatment of Covid-19 and infections with the black fungus. For maximum efficacy, comprising biodistribution, bioavailability, and drug functionality, we describe innovative strategies based on nanomedicines for targeted delivery of TQ to the lungs and intranasal delivery to the brain, bypassing the blood-brain barrier. After these promising strategies as the next step, a clinical study for proof of concept should be initiated.
Health-care activities protect and restore health and save lives. But what about the waste and by-products they generate?
Authors: Khan M Karim
Published: June 2021

Abstract not available

CBMJ 2016 July: Vol. 05 No. 02 P: 01-03
Adolescent Health needs - Special attention and a New Subspeciality - Adolescent Medicine
Authors: Yasmeen BH Nazma
Published: June 2021

Abstract Not Available

Northern International Medical College Journal Vol.11 (2) Jan 2020: 443- 446
Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients
Authors: Chung Hyun Woo , Park Ji-Hye , Yoo Chungkwon , Kim Yong Yeon
Published: June 2021

Purpose: To evaluate the effects of baseline trabecular meshwork (TM) and Schlemm’s canal (SC) microstructures on intraocular pressure (IOP) reduction amount in treatment-naïve patients with primary open-angle glaucoma (POAG).Methods: A total 69 eyes of POAG patients who had not been treated with IOP-lowering agent were enrolled in this retrospective study. The patients had been prescribed topical IOP-lowering agent and used it for 1 year. The morphologic features of the TM and SC were collected using anterior segment module of spectral-domain optical coherence tomography with enhanced depth imaging at baseline. Images of the nasal and temporal corneoscleral limbus were obtained with serial horizontal enhanced depth imaging B-scans and TM width and SC area were measured in each scan. We investigated the effects of baseline TM and SC microstructures on IOP reduction amount.Results: The baseline IOP of 69 glaucomatous eyes was 17.9 ± 3.8 mmHg, and the mean amount of IOP reduction was 3.5 ± 2.1 mmHg after 1 year. Mean TM widths of nasal and temporal sector were 470.33 ± 80.05 and 479.74 ± 79.59 μm, respectively. SC area was measured as 4,818.50 ± 1,464.28, 4,604.23 ± 1,567.73 μm2 at nasal sector and temporal sector, respectively. The correlation analysis revealed a positive correlation between SC area and average amount of IOP reduction, indicating that the larger baseline SC area, the greater the IOP drop with topical IOP-lowering agents. However, no correlation was found between TM width and IOP lowering amount in patients with POAG.Conclusions: The baseline SC area showed positive correlation with the IOP reduction amount in patients with POAG. This finding suggests that the SC area can be a clinical parameter to predict the IOP reduction amount before using IOP-lowering agents in POAG patient.
A SURVEY ON STOCK PRICE PREDICTION USING MACHINE LEARNING
Authors: Mishra Manavi , Patil Manjushree , Raut Geetanjali , Chaudhari Tushar
Published: June 2021

Stock returns are very fluctuating in nature.
They rely upon various factors like previous stock prices,
current market trends, financial news, etc. To feature their
annual income, people have now started watching stock
investments as a remunerative option. There are many tools
available to investors using technical analysis to form
decisions. With expert guidance and intelligent planning, we
will almost double our annual income through stock
returns. These days, social media has become a mirror. It
reflects people’s thoughts and opinions on any particular
event or news. Sentiments of the general public associated
with an organization can have an upshot on its stock prices.
This paper surveys various machine learning techniques
and algorithms employed to boost the accuracy of stock
price prediction.
Moving is in Every Direction
Authors: Flach Sabine
Published: June 2021

Traditionally, art history divided the arts into four genres: painting and sculpture, poetry and music. Hence the art-historical canon was dominated by a strict division into the arts of space and those of time. Movement (both of an internal and externalized kind) did not find a place within this classificatory corset. In 1766, Gotthold Ephraim Lessing framed the classical art-theoretical approach through his famous text ‚Laocoon: An Essay on the Limits of Painting and Poetry‘, in which he splits the arts into those unfolding in time and those unfolding in space. Lessing’s ‚Laocoon‘ is the founding text defining poetry and music as time-based, sculpture and painting as space-orientated. By 1900, this strict system of classification and hierarchization began to dissolve, giving way to cross-border experiments in the arts of the twentieth century up to the present day. This overturning of classical genre divisions between the static and the dynamic arts, between sculpture, installation, and performance enables us to examine artworks as variations of movement in terms of ‚constellations between scene and scenario‘. Furthermore, the development of movement as an artform implies the activation of the audience in participatory arts practice.
Bewegung, Mythologie der Moderne
Authors: Hülk Walburga
Published: June 2021

Paul Valéryʼs remark »Nouvelle mythologie / les formes en mouvement / connaître c’est former« (1894) states the argument of the present article. Its intention is to highlight the importance of movement in modern arts and research studies. It observes the fascination which movement held for artists and scientists who were trying to comprehend the dynamics of physical and mental processes in creative work and to find appropriate forms for volatility and complexity in traditional and recent arts and media. The focal point of this article are the works of Charles Baudelaire, Hippolyte Taine and the futurist avantgarde, especially Umberto Boccioni, as well as physiological studies on the effects of huge cities, crowds, sports, acceleration, and aeroplanes (Angelo Mosso, William James). In this context, Valéry’s poems, essays and notes appear as a crossover project and Valéry himself as a protagonist of the intense dialogue between the arts, media and sciences concerningmovement as physical and mental phenomenon and stylistic challenge.
Notieren im Tanz
Authors: Wortelkamp Isa
Published: June 2021

Note taking is a choreographic writing practice that implies processes of thinking, projecting and rejecting ideas. Note by note, a complex scenery of movement emerges through reflexive practices of writing, which are designed for a performative event. This article explores different forms of choreographic notation from the perspective of their performative dimensions and draws on approaches from literary theory, procedures of drafting and drawing, as well as considerations of writing as a thought process. The emphasis will be on specific examples of contemporary dance.
Closing (Policy): Building international partnerships to support and achieve adaptation and resilience
Authors: Mfitumukiza David , Bueno Rubial María del Pilar , Ranger Nicola , West Rosalind , Huq Saleemul , Lombardi Patrizia
Published: June 2021

This session builds on the insights from the session Accelerating Adaptation in the Global South, with a strong policy focus. The panel discussion will focus around the various initiatives being developed to mainstream and expand the amount of action-orientated research being undertaken to rise to the global climate emergency. In particular, the session will discuss the role of agriculture in the Adaptation Research Alliance and how to transform agricultural systems innovation for people, nature and climate.
Engaging people as agents of change
Authors: Davies Anna , Wilson Charlie , Otto Ilona , Whitmarsh Lorraine , Munang Richard
Published: June 2021

This session will explore contrasting perspectives on social engagement as an enabler of mitigation solutions.
Product Inhibition and pH Affect Stoichiometry and Kinetics of Chain Elongating Microbial Communities in Sequencing Batch Bioreactors
Authors: Allaart Maximilienne Toetie , Stouten Gerben Roelandt , Sousa Diana Z. , Kleerebezem Robbert
Published: June 2021

Anaerobic microbial communities can produce carboxylic acids of medium chain length (e.g., caproate, caprylate) by elongating short chain fatty acids through reversed β-oxidation. Ethanol is a common electron donor for this process. The influence of environmental conditions on the stoichiometry and kinetics of ethanol-based chain elongation remains elusive. Here, a sequencing batch bioreactor setup with high-resolution off-gas measurements was used to identify the physiological characteristics of chain elongating microbial communities enriched on acetate and ethanol at pH 7.0 ± 0.2 and 5.5 ± 0.2. Operation at both pH-values led to the development of communities that were highly enriched (>50%, based on 16S rRNA gene amplicon sequencing) in Clostridium kluyveri related species. At both pH-values, stably performing cultures were characterized by incomplete substrate conversion and decreasing biomass-specific hydrogen production rates during an operational cycle. The process stoichiometries obtained at both pH-values were different: at pH 7.0, 71 ± 6% of the consumed electrons were converted to caproate, compared to only 30 ± 5% at pH 5.5. Operating at pH 5.5 led to a decrease in the biomass yield, but a significant increase in the biomass-specific substrate uptake rate, suggesting that the organisms employ catabolic overcapacity to deal with energy losses associated to product inhibition. These results highlight that chain elongating conversions rely on a delicate balance between substrate uptake- and product inhibition kinetics.
HIF-1α Affects the Neural Stem Cell Differentiation of Human Induced Pluripotent Stem Cells via MFN2-Mediated Wnt/β-Catenin Signaling
Authors: Cui Peng , Zhang Ping , Yuan Lin , Wang Li , Guo Xin , Cui Guanghui , Zhang Yanmin , Li Minghua , Zhang Xiaowei , Li Xiaoqiang , Yin Yuxin , Yu Zhendong
Published: June 2021

Hypoxia-inducible factor 1α (HIF-1α) plays pivotal roles in maintaining pluripotency, and the developmental potential of pluripotent stem cells (PSCs). However, the mechanisms underlying HIF-1α regulation of neural stem cell (NSC) differentiation of human induced pluripotent stem cells (hiPSCs) remains unclear. In this study, we demonstrated that HIF-1α knockdown significantly inhibits the pluripotency and self-renewal potential of hiPSCs. We further uncovered that the disruption of HIF-1α promotes the NSC differentiation and development potential in vitro and in vivo. Mechanistically, HIF-1α knockdown significantly enhances mitofusin2 (MFN2)-mediated Wnt/β-catenin signaling, and excessive mitochondrial fusion could also promote the NSC differentiation potential of hiPSCs via activating the β-catenin signaling. Additionally, MFN2 significantly reverses the effects of HIF-1α overexpression on the NSC differentiation potential and β-catenin activity of hiPSCs. Furthermore, Wnt/β-catenin signaling inhibition could also reverse the effects of HIF-1α knockdown on the NSC differentiation potential of hiPSCs. This study provided a novel strategy for improving the directed differentiation efficiency of functional NSCs. These findings are important for the development of potential clinical interventions for neurological diseases caused by metabolic disorders.
Social-Emotional Learning Amidst COVID-19 School Closures: Positive Findings from an Efficacy Study of Adventures Aboard the S.S. GRIN Program
Authors: Li Linlin , Flynn Kylie S. , DeRosier Melissa E. , Weiser Gary , Austin-King Kelsey
Published: June 2021

School closures because of natural phenomena, such as COVID-19, have emphasized the importance of effective distance learning strategies when there are no in-person alternatives. Although infrequently mentioned in discussions of student performance, social-emotional skill building came to the forefront of conversations due to the isolation and stresses created by stay-at-home protocols. Our original research study describes the implementation of a game-based online social-emotional learning program during in-person learning and how we adapted implementation to distance learning due to COVID-19 based on schools’ infrastructure, preparations, and resource availability. In addition to the successful implementation, the results have indicated that the program was significantly and positively associated with gains in students’ social emotional skills.
Association Between the Concentration and Rangeability of Cystatin C and Mortality of COVID-19 Patients With or Without Type 2 Diabetes Mellitus: A Retrospective Analysis
Authors: Yang Lei , Xu Dou , Tan Yiqing , Li Bolin , Zhu Dan , Wang Jingbo , Sun Hui , Liu Xinglong , Zheng Xiaopu , Zhu Ling , Li Zhongyu
Published: June 2021

Background

We investigated if the concentration and “rangeability” of cystatin C (CysC) influenced the prognosis of coronavirus disease 2019 (COVID-19) in patients suffering from, or not suffering from, type 2 diabetes mellitus (T2DM).

Methods

A total of 675 T2DM patients and 572 non-T2DM patients were divided into “low” and “high” CysC groups and low and high CysC-rangeability groups according to serum CysC level and range of change of CysC level, respectively. Demographic characteristics, clinical data, and laboratory results of the four groups were analyzed.

Results

COVID-19 patients with a high level and rangeability of CysC had more organ damage and a higher risk of death compared with those with a low level or low rangeability of CysC. Patients with a higher level and rangeability of CysC had more blood lymphocytes and higher levels of C-reactive protein, alanine aminotransferase, and aspartate aminotransferase. After adjustment for possible confounders, multivariate analysis revealed that CysC >0.93 mg/dL was significantly associated with the risk of heart failure (OR = 2.231, 95% CI: 1.125–5.312) and all-cause death (2.694, 1.161–6.252). CysC rangeability >0 was significantly associated with all-cause death (OR = 4.217, 95% CI: 1.953–9.106). These associations were stronger in patients suffering from T2DM than in those not suffering from T2DM.

Conclusions

The level and rangeability of CysC may influence the prognosis of COVID-19. Special care and appropriate intervention should be undertaken in COVID-19 patients with an increased CysC level during hospitalization and follow-up, especially for those with T2DM.
Low-Cost Single Chamber MFC Integrated With Novel Lignin-Based Carbon Fiber Felt Bioanode for Treatment of Recalcitrant Azo Dye
Authors: Fatima Masoom , Kiros Yohannes , Farooq Robina , Lindström Rakel W.
Published: June 2021

A flow through anaerobic microbial fuel cell (MFC) was designed and optimized for efficient treatment of recalcitrant textile wastewater. The membrane-less MFC was first time fabricated with a unique combination of electrodes, a novel bioanode of synthesized lignin-based electrospun carbon fiber supporting a biofilm ofGeobacter sulfurreducensfor acetate oxidation and an air-breathing cathode, consisting of a pyrolyzed macrocycle catalyst mixture on carbon bonded by polytetrafluoroethylene (PTFE). The effects of different organic loadings of acetate along with Acid Orange (AO5), operation time and ionic strength of auxiliary salts (conductivity enhancers) were investigated and responses in terms of polarization and degradation were studied. In addition, the decomposition of the organic species and the degradation of AO5 along with its metabolites and degraded products (2-aminobenzenesulfonic acid) were determined by chemical oxygen demand (COD) analysis, UV-Vis spectrophotometry and high-performance liquid chromatography (UV-HPLC) techniques. SEM and TEM images were also used to find out the biocompatibility of the microbes on lignin-based electrospun carbon felt anode and the morphology of the cathode. Reduction and breakage of the azo bond of AO5 occurs presumably as a side reaction, resulting in the formation of 2-aminobenzenesulfonic acid and unidentified aromatic amines. Maximum current density of anode 0.59 Am−2and power density of 0.12 Wm−2were obtained under optimized conditions. As a result, decolouration of AO5 and chemical oxygen demand (COD) removal efficiency was 81 and 58%, respectively. These results revealed that the low-cost MFC assembly can offer significant potential for anaerobic decolouration of recalcitrant textile wastewater.
Application of Machine Learning for Drug–Target Interaction Prediction
Authors: Xu Lei , Ru Xiaoqing , Song Rong
Published: June 2021

Exploring drug–target interactions by biomedical experiments requires a lot of human, financial, and material resources. To save time and cost to meet the needs of the present generation, machine learning methods have been introduced into the prediction of drug–target interactions. The large amount of available drug and target data in existing databases, the evolving and innovative computer technologies, and the inherent characteristics of various types of machine learning have made machine learning techniques the mainstream method for drug–target interaction prediction research. In this review, details of the specific applications of machine learning in drug–target interaction prediction are summarized, the characteristics of each algorithm are analyzed, and the issues that need to be further addressed and explored for future research are discussed. The aim of this review is to provide a sound basis for the construction of high-performance models.
A Decade of Incorporating Social Sciences in the Integrated Marine Biosphere Research Project (IMBeR): Much Done, Much to Do?
Authors: van Putten Ingrid , Kelly Rachel , Cavanagh Rachel D. , Murphy Eugene J. , Breckwoldt Annette , Brodie Stephanie , Cvitanovic Christopher , Dickey-Collas Mark , Maddison Lisa , Melbourne-Thomas Jess , Arrizabalaga Haritz , Azetsu-Scott Kumiko , Beckley Lynnath E. , Bellerby Richard , Constable Andrew J. , Cowie Greg , Evans Karen , Glaser Marion , Hall Julie , Hobday Alistair J. , Johnston Nadine M. , Llopiz Joel K. , Mueter Franz , Muller-Karger Frank E. , Weng Kevin C. , Wolf-Gladrow Dieter , Xavier José C.
Published: June 2021

Successful management and mitigation of marine challenges depends on cooperation and knowledge sharing which often occurs across culturally diverse geographic regions. Global ocean science collaboration is therefore essential for developing global solutions. Building effective global research networks that can enable collaboration also need to ensure inter- and transdisciplinary research approaches to tackle complex marine socio-ecological challenges. To understand the contribution of interdisciplinary global research networks to solving these complex challenges, we use the Integrated Marine Biosphere Research (IMBeR) project as a case study. We investigated the diversity and characteristics of 1,827 scientists from 11 global regions who were attendees at different IMBeR global science engagement opportunities since 2009. We also determined the role of social science engagement in natural science based regional programmes (using key informants) and identified the potential for enhanced collaboration in the future. Event attendees were predominantly from western Europe, North America, and East Asia. But overall, in the global network, there was growing participation by females, students and early career researchers, and social scientists, thus assisting in moving toward interdisciplinarity in IMBeR research. The mainly natural science oriented regional programmes showed mixed success in engaging and collaborating with social scientists. This was mostly attributed to the largely natural science (i.e., biological, physical) goals and agendas of the programmes, and the lack of institutional support and push to initiate connections with social science. Recognising that social science research may not be relevant to all the aims and activities of all regional programmes, all researchers however, recognised the (potential) benefits of interdisciplinarity, which included broadening scientists’ understanding and perspectives, developing connections and interlinkages, and making science more useful. Pathways to achieve progress in regional programmes fell into four groups: specific funding, events to come together, within-programme-reflections, and social science champions. Future research programmes should have a strategic plan to be truly interdisciplinary, engaging natural and social sciences, as well as aiding early career professionals to actively engage in such programmes.