bluuebunny/crossref_metadata_2025 huggingface dataset:
Les Conditions D’Approfondissement de L’Union Européenne
Authors: Gagnon Jonathan
Published: October 2019

Since the creation of the first European Community in 1951, countries of Europe have somewhat integrated somewhat their political and economic realms into one supranational entity. It has been observed by some that throughout the integration process, economic factors, rather than political factors, have dominated the integration of Europe. This main assumption is challenged by the author in this article. However, if the alleged predominance of the economy in European integration is proven, further questions regarding the conditions for a authentic political integration of the European Union, more than 50 years after its creation, will be assessed.[...]
MEREKONTRUKSI KURIKULUM BERBASIS KARAKTER DI SEKOLAH DASAR
Authors: Sutrisno Tri
Published: October 2019

Akhir-akhir ini konsentrasi pemerintah seolah terkuras dengan fenomena dekadensi moralitas bangsa. Membangun karakter bukanlah sesuatu yang mudah, juga tidak teramat sulit, membutuhkan proses, strategi dan koordinasi. Pendidikan merupakan wahana peserta didik untuk memperoleh layanan pembentukan karakter. Pendidikan karakter seyogyanya dilakukan sejak usia dini atau selambat-lambatnya dibangku sekolah dasar (SD). Diusia inilah seseorang dapat dengan mudah dibentuk, diarahkan dan dibina sesuai keinginan. Pendidikan juga terus melakukan perubahan, yang semua itu bermuara terhadap pembentukan karakter siswa. Akhir-akhir ini, program penguatan pendidikan karakter (PPK) bentukan Mendikbud menjadi dambaan besar dari pengembangan karakter anak. Sebagai inti dari kegiatan pendidikan karakter adalah pembelajaran yang menyesuaikan dengan kondisi anak. Pembelajaran dirancang tidak hanya melejitkan ranah kognitif saja, tetapi juga ranah afektif, yang terdiri dari pengembangan emosi, sosial dan spiritual (karakter). Sebagai pendukung utama dalam pendidikan karakter, layanan BK juga mempunyai peran strategis menemani anak dalam mengembangkan karakter positif. Sekolah adalah komponen dari beberapa individu yang mempunyai visi terselenggaranya pendidikan secara efektif. Efektifitas dari pendidikan saat ini adalah, mampu mengembangkan karakter positif anak ditengah mencuatnya krisis moral pada generasi bangsa.
Arte versus Cultura
Authors: Montechiare Renata
Published: October 2019

Este trabalho considera o cenário museológico europeu contemporâneo como ponto de partida para o debate sobre como coleções etnográficas vêm sendo reinterpretadas e exibidas sob novas condições. A Sala de África do Museo de Culturas del Mundo de Barcelona (MCM) é aqui tomada como caso que aglutina percepções contrastantes sobre o que se considera que museus como este devem ser, como devem lidar com as coleções que possuem, a quem se dirigem e em que medida criam pontes com os campos de pesquisa que acionam. Arte, antropologia e museologia compõem o universo de disputas que envolveu a criação do MCM na Catalunha em 2015.
STRUCTURE OF NOSOCOMIAL INFECTIOUS AND INFLAMMATORY COMPLICATIONS AFTER ABDOMINAL DELIVERY
Authors:   Department of Women’s Reproductive Health, North-West State Medical University named after I.I. Mechnikov, Korobkov Nikolay Aleksandrovich
Published: October 2019

Objective: Analysis of the frequency and structure of postoperative infectious and inflammatory complications in the puerperae after abdominal delivery, which were under treatment in the specialized department of the third-level hospital for 2017. Methods: s: Examined and treated of 66 parturient women with infectious complications after cesarean section. The spectrum of nosocomial microflora and resistance to antimicrobial agents determined using an automatic microbiological analyzer based on mass spectrometry. Results: The main recorded nosological form was infection of the area of surgical intervention. In 3% of cases, postoperative metroendometritis complicated by the inconsistency of sutures on the uterus with the development of obstetric peritonitis, and in 7.6% by sepsis. The structure of isolated microflora in postoperative infection was different after planned and emerged delivery, which should be taken into account when developing a local form of perioperative antibiotic prophylaxis and therapy. Conclusion: At present, there is an underestimation of the severity of metroendometritis after cesarean section with premature discharge or a belated transfer from the maternity hospital to the specialized observatory department of the multi-profile hospital. One in five postoperative metroendometritis caused by multidrug-resistant hospital microflora. Keywords: Caesarean section, infectious complications, observational department, obstetric wound infection, postnatal metroendometritis, postpartum sepsis, obstetric peritonitis.
THE INCIDENCE OF LEUKAEMIA IN KYRGYZSTAN IN CHILDREN UNDER 5 YEARS
Authors:   Department of Surgical Diseases, International Higher School of Medicine, Usenova Asel Abdumomunovna
Published: October 2019

Objective: To study the incidence rates of acute lymphoblastic and myeloblastic leukaemia in the age category of children under 5 years. Methods: For the period 2006-2016 were registered 175 cases of acute leucosis in the age category under 5 years in Kyrgyzstan. In 144 cases (82.9%) there was acute lymphoblastic and in 30 cases (17.1%) acute myeloblastic leukaemia. Results: The incidence rates in the age group from one to 5 years, in both groups had higher rates compared to the age of up to 1 year. For boys under 1 year the incidence was 12.14 and at the age of 1 to 5 years – 30.76 per 1 million population, for girls these figures were equal to 7.89 and 17.76 respectively. In contrast to the incidence of acute lymphoblastic leukaemia, morbidity of the incidence of acute myeloblastic leukaemia in rural areas turned out to be more than inhabitants of the city, amounting to 5.47 and 2.88 per million people, respectively. Conclusion: The incidence of acute leukaemia in the age category under 1 year is low. The highest incidence rates are registered in the age category from one to 5 years. The incidence of acute leukaemia in boys was higher than that of girls. Keywords: Acute lymphoblastic leukaemia, acute myeloblastic leukaemia, infant leukaemia, standardized incidence rate.
PECULIARITIES OF DIAGNOSTICS, SURGICAL TACTICS AND RESTORATION OPERATIONS IN NECROTIZING INFECTION OF SOFT TISSUES
Authors:   Department of General Surgery № 2, Avicenna TSMU, Nabiev Muzaffar Kholnazarovich , Yusupova Shoira ,   Department of General Surgery № 2, Avicenna TSMU, Azimov Akhtamshoh Talabshoevich ,   Department of General Surgery № 2, Avicenna TSMU, Boronov Talabshoh Boronovich ,   Department of General Surgery № 2, Avicenna TSMU
Published: October 2019

Objective: Improving diagnostic results and surgical treatment of necrotizing soft tissue infection. Methods: Analyzed the results of diagnostics and treatment of 68 patients with various forms of necrotizing infection for the period 2010-2017. There were 32 men (53.8%), women – 36 (46.2%) at the age of 30-84. In 27 (39.7%) patients the necrotic form of erysipelas occurred, in 41 (60.3%) necrotizing fasciitis and myonecrosis. In 60.3% of cases, the pathological process was localized in the region of the lower extremities. More than 90% of the patients had concomitant diseases, among them diabetes mellitus (78.2%), arterial hypertension (83.3%), coronary artery disease (75.6%) and anaemia of varying severity (74.3%). Results: The clinical picture of streptococcal necrotizing fasciitis (n=31) and myonecrosis (n=10) in the early stages was characterized by the absence of pathognomonic symptoms. The discrepancy between the severity of the general condition and local status in a number of cases led to the belated surgical intervention and, as a result, extensive postoperative wounds, requiring 16 cases of plastic closure. In 12 (75%) cases, full engraftment was noted, in 3 (18.7%) partial engraftment and in 1 (6.3%) observation – complete necrosis of the graft. Conditions of transplant engraftment were corrected carbohydrate metabolism, preserved regional hemodynamics and the presence of actively granulating wound surface. Conclusion: Necrotizing infection, which is a nonspecific inflammatory process of soft tissues, is characterized by progressive necrosis, rapid spreading, difficulty in diagnosing in the early stages of the disease, pronounced intoxication and high lethality. Keywords: Necrotizing infection , fasciitis , free skin grafting , surgical tactics.
Resources in shaping the efficiency of dynamic capabilities of Polish enterprises
Authors: Tsifert Sh. , Kshakevich K.
Published: October 2019

The dynamic capabilities, representing the organization’s competence to integrate, create and reconfigure internal and external competencies to ensure compliance with constantly changing environmental conditions, allow the organization to achieve a competitive advantage in the long term. The assumption of the background about the importance of dynamic capabilities for understanding the phenomenon of competition raises the question of the variables, affecting the effectiveness of the processes of formation of dynamic capabilities.

The aim of this paper is discussion of the results of studies on the impact of resources on the effectiveness of the processes of formation of dynamic capabilities of Polish enterprises. The nature and essence of dynamic abilities of enterprises have been characterized in the article, the value of resources in the processes of formation of dynamic abilities of Polish enterprises has been noted, which subsequently allowed to formulate conclusions about the relationship between resources and efficiency of processes of formation of dynamic abilities of Polish enterprises have been formulated. The results of the research resources in the processes of formation of dynamic capabilities of Polish enterprises, presented in the paper, are fragment of the research project, whose goal is to develop a paradigm concept of dynamic capabilities from the perspective of strategic management, identification and analysis of dynamic capabilities of Polish enterprises.

According to respondents in the process of questioning, sources of efficiency should be sought in external variables (customer loyalty, market share, sales growth), but not in internal variables (employment growth). Such a state, indicating the orientation of the organization outward, should be considered correct from the point of view of the logic of the dominant ways of constructing a strategy, since it indicates an understanding of the needs of the environment, while dynamically comparing with the expectations of this environment and the resources available to the organization.
Formation of competitive advantages of Russian transnational corporations in the context of globalization
Authors: Mozgovoy A.
Published: October 2019

The general issues of competitiveness of transnational corporations have been considered. Research of the problem of competitiveness of Russian transnational corporations on the world market and the formation of their competitive advantages for sustainable development in a globalized economy has been сonducted. The author’s interpretation of the concept of “enterprise competitiveness” has been proposed.

In a global liberalized economy, transnational corporations have the opportunity to influence geopolitical issues in international trade and employment, as well as dictate their own rules. The constant increase in the level of competitiveness of a small group of transnational corporations has been noted in the article, the format of competition in industry and regional markets is often oligopolistic. Building a true global strategy for the development of transnational corporations and obtaining a competitive advantage by them is impossible without sufficient knowledge of current trends in globalization: globalization of the market, globalization of costs, globalization of competition, globalization of government policies. The methods of obtaining competitive advantages of transnational corporations have been adduced and сharacterized.

For Russian transnational corporations, the issue of their competitiveness is very acute in the markets of rapidly turning goods or in the markets of new technologies. Factors, hindering the growth of the competitiveness of Russian corporations: incorrect corporate policies, leading to inefficiency of personnel motivation, corporate culture, inconsistency with international standards, incorrect alignment of the global strategy, lack of reciprocity principles and correct negotiation. This creates a negative image of the company, which affects its position, and subsequently its competitiveness. Competitiveness is one of the most important factors for ensuring the sustainable development of the economy of Russian corporations. The criteria for assessing sustainability, the corporations should meet have been suggested.
Online sales funnel as an analytical tool for business efficiency management
Authors: Vasilieva E. , Loseva V.
Published: October 2019

The possibilities of online sales strategy analysis based on unit-economy metrics (Unit Economics is a new economic modeling method used to determine the effectiveness of a digital business model by assessing the profitability of a product unit or a single customer), as well as on the theory of restrictions, have been shown. The peculiarities of settings of problems on monitoring the process of attracting customers to the electronic resource of a company, and their support up to conclusion of commercial transaction (product sale) have been revealed. A scenarios matrix for promoting information about a product, a brand, or a service using various communication channels has been compiled.

Among various strategies of a sales funnel management the following three main strategies have been highlighted: the strategy of a proportional expansion (when increasing a traffic at the entrance of a funnel, which gives a large conversion, the funnel expands at all next stages, and the output result is increased); the strategy of stretching (increasing of a conversion at each level results in the output increasing), and the strategy of a key level (this strategy demands to determine the level of the funnel, which limits the entire system, and to apply efforts to improve conversion indicators at this special level). A methodology for constructing and analyzing the product funnel using unit-economy metrics has been adduced. The peculiarities of development of strategies for sales funnel using the critical-chain method (Critical Chain Management, CPM) and method of Theory of Constraints (TOC) have been highlighted, when the company’s results depend on the interacting elements of the system, that create the constraints. A method of searching bottlenecks in the sales funnel has been proposed, which consists in a consistent assessment of the impact on the profits of each of its five basic metrics, for each of which there are special development tools, allowing one to find points of rapid profit growth. Scenario analysis of sales funnel using unit metrics has been сarried out.
Competitive strategies of differentiation and cost minimization
Authors: Mikhailov O.
Published: October 2019

The strategies of differentiation and cost minimization are oriented on reception of competitive advances in the broad range of industries/branches, that allows companies to achieve effective exceed in the industry-average indicators. Using the both strategies can bring the synergetic effect in competition of the subjects and objects. These strategies can reinforce each other and the competitive advances of the company. Strategies of cost minimization and differentiation can coexist and compete. Cost leadership strategy focuses on getting advantages by reducing cost below analogies of all competitors. It is unsufficient the single of cost minimization in the international competing, it is necessary the complex and creative decision of the compound problems, associated with differentiation of products and services.

Product differentiation is a business strategy, whereby firms attempt to gain a competitive advantage by increasing the perceived value of their products/services relative to perceived value the other products/services firms; with recording dissatisfied inquiring the customers. Especially distinctive characteristics, properties, attributes of products or services can be one or more-the main thing that they were really important, more useful and valuable for buyers. The differentiation can create on the basis the timing of product introduction, product customization, the best joining the product and services or simultaneously combination of these advantages. Product differentiation is ultimately an expression of the creativity of individuals and groups within the firm. It is limited not only by opportunities, than exist, or than can be created, in particular industry, but by the willingness and ability of firms to creatively explore ways to take advantage of those opportunities.

The willingness of consumers to pay more suggests, that important perceptual bases of product differentiation exist. Successful implementation of these strategies can increase consumer sensations/perceptions of the greater value of products/ services and contribute to the expansion of their exports and strengthen the competitiveness of the company in the global economy. The ideal strategy-building process is to achieve a high level of commitment of employees and consumers around a high-quality strategy and the best ways to implement it.
Transformer-CNN: Fast and Reliable Tool for QSAR
Authors: Karpov Pavel , Godin Guillaume , Tetko Igor
Published: October 2019

We present SMILES-embeddings derived from internal encoder state of a Transformer model trained to canonize SMILES as a Seq2Seq problem. Using CharNN architecture upon the embeddings results in a higher quality QSAR/QSPR models on diverse benchmark datasets including regression and classification tasks. The proposed Transformer-CNN method uses SMILES augmentation for training and inference, and thus the prognosis grounds on an internal consensus. Both the augmentation and transfer learning based on embedding allows the method to provide good results for small datasets. We discuss the reasons for such effectiveness and draft future directions for the development of the method. The source code and the embeddings are available on https://github.com/bigchem/transformer-cnn, whereas the OCHEM environment (https://ochem.eu) hosts its on-line implementation.
In-Situ Formation of H-Bonding Imidazole Chains in Break-Junction Experiments
Authors: Wu Chuanli , Alqahtani Aminah , Sangtarash Sara , Vezzoli Andrea , Sadeghi Hatef , Robertson Craig M. , Cai Chenxin , Lambert Colin , Higgins Simon , Nichols Richard
Published: October 2019

As a small molecule possessing both strong H-bond donor and acceptor functions, 1H-imidazole can participate in extensive homo- or heteromolecular H-bonding networks. These properties are important in Nature, as imidazole moieties are incorporated in many biologically-relevant compounds. Imidazole also finds applications ranging from corrosion inhibition to fire retardants and photography. We have found a peculiar behaviour of imidazole during scanning tunnelling microscopy-break junction (STM-BJ) experiments, in which oligomeric chains connect the two electrodes and allow efficient charge transport. We attributed this behaviour to the formation of hydrogen-bonding networks, as no evidence of such behaviour was found in 1-methylimidazole (incapable of participating in intramolecular hydrogen bonding). The results are supported by DFT calculations, which confirmed our hypothesis. These findings pave the road to the use of hydrogen-bonding networks for the fabrication of dynamic junctions based on supramolecular interactions.
Structure-Property Relationships in Unsymmetric Bis(antiaromatics): Who Wins the Battle Between Pentalene and Benzocyclobutadiene?
Authors: Mayer Péter J. , El Bakouri Ouissam , Holczbauer Tamás , Samu Gergely F. , Janáky Csaba , Ottosson Henrik , London Gábor
Published: October 2019

According to the currently accepted structure-property relationships, aceno-pentalenes with angular shape (fused to the 1,2-bond of the acene) exhibit higher antiaromaticity than those with linear shape (fused to the 2,3-bond of the acene). To explore and expand the current view, we designed and synthesized molecules where two isomeric, yet, different, 8π antiaromatic subunits, a benzocyclobutadiene (BCB) and a pentalene are combined into, respectively, an angular and a linear topology via an unsaturated 6-membered ring. The antiaromatic character of the molecules are supported experimentally by 1H NMR, UV-Vis and cyclic voltammetry measurements and X-ray crystallography. The experimental results are further confirmed by theoretical studies including the calculation of several aromaticity indices (NICS, ACID, HOMA, FLU, MCI). In the case of the angular molecule, double bond-localization within the connecting 6-membered ring resulted in reduced antiaromaticity of both the BCB and pentalene subunits, while the linear structure provided a competitive situation for the two unequal [4n]π subunits. We found that in the latter case pentalene drew the shorter straw. The BCB unit alleviated its unfavorable antiaromaticity more efficiently, leaving the pentalene with enhanced antiaromaticity. Thus, a reversed structure-antiaromaticity relationship when compared to aceno-pentalenes was achieved.
Origins of Negative and Positive Electromechanical Response of Oligopeptide Piezoelectrics
Authors: Gayatri Ni Nyoman D. , Hutchison Geoffrey
Published: October 2019

In response to an applied electric field, materials and even individual molecules can exhibit electromechanical response. Previous work has demonstrated the piezoelectric distortion of polar organic crystals, biomaterials, and even single molecular monolayers, increasing length in response to the change in potential energy of interaction between the polarization or dipole moment and the applied electric field. In this work, we demonstrate through density functional calculations that helical oligopeptides, depending on sequence can exhibit both positive and surprisingly also negative piezoresponse. While the overall molecular dipole moment may favor positive piezoresponse, individual hydrogen bonding interactions along the backbone have the opposite direction, enabling tailored sequences to yield either net expansion or contraction in response to an electric field. While negative piezoresponse has largely been considered in polyvinylidene difluoride (PVDF) and related systems, understanding the atomic and molecular basis for both electromechanical effects will yield interesting new applications.
The Catalytic Acid-Base in GH109 Resides in a Conserved GGHGG Loop and Allows for Comparable α-Retaining and β-Inverting Activity in an N-Acetylgalactosaminidase from Akkermansia Muciniphila
Authors: Teze David , Shuoker Bashar , Chaberski Evan Kirk , Kunstmann Ruth Sonja , Fredslund Folmer , Peters Günther H.J. , Karlsson Eva Nordberg , Welner Ditte Hededam , Abou Hachem Maher
Published: October 2019

The study describes the first glycoside hydrolase that exhibits comparable levels of activity on α- and β-linked saccharide substrates. This enzyme, assigned into GH109, is encoded by the genome of the human gut symbiont Akkermansia muciniphila that is a model primary degrader of the heavily O-glycosylated mucin glycoprotein that coats the epithelial enterocytes.The elusive catalytic acid/base catalyst in GH109 enzymes is identified as a histidine that is presented by a flexible loop that positions it for catalysis on both α- and β-substrates. This dual activity may be an evolutionary adaptation to extend the range of substrates targeted by a single non-canonical NAD+-dependant GH.
HIV Capsid Inhibitor Capacity of Different Isomers of Di-Pyridine Benzene and Its Alkyl and Halide Derivatives
Authors: Biswas Nilanjana , Ghosh Sangita , Bag Arijit
Published: October 2019

HIV-1 Capsid-A inhibitor capacity of different isomers of di-pyridine benzene and its alkyl and halide derivatives are studied systematically. It is found that p-di-pyridine o-ethyl benzene has very good inhibition constant. It is a small, cost effective organic compound and very promising as a HIV drug. It is a molecular docking based study.
Probing the Inverse Trans Influence in Americium and Lanthanide Tribromide Tris(tricyclohexylphosphine oxide)
Authors: Windorff Cory , Celis-Barros Cristian , Sperling Joseph , Mckinnon Noah , Albrecht-Schmitt Thomas
Published: October 2019

The synthesis, characterization, and theoretical analysis of meridional americium tribromide tris(tricyclohexylphosphine oxide), mer-AmBr3(OPcy3)3 has been achieved and is compared with its early lanthanide (La to Nd) analogs. The data show that homo trans ligands show significantly shorter bonds than the cis or hetero trans ligands. This is particularly pronounced in the americium compound. DFT along with multiconfigurational CASSCF calculations show that the contraction of the bonds relates qualitatively with overall covalency, i.e. americium shows the most covalent interactions compared to lanthanides. . However, the involvement of the 5p and 6p shells in bonding follows a different order, namely cerium > neodymium ~ americium. This study provides further insight into the mechanisms by which ITI operates in low-valent f-block complexes.
Minimum Mode Saddle Point Searches Using Gaussian Process Regression with Inverse-Distance Covariance Function
Authors: Koistinen Olli-Pekka , Ásgeirsson Vilhjálmur , Vehtari Aki , Jónsson Hannes
Published: October 2019

The minimum mode following method can be used to find saddle points on an energy surface by following a direction guided by the lowest curvature mode. Such calculations are often started close to a minimum on the energy surface to find out which transitions can occur from an initial state of the system, but it is also common to start from the vicinity of a first order saddle point making use of an initial guess based on intuition or more approximate calculations. In systems where accurate evaluations of the energy and its gradient are computationally intensive, it is important to exploit the information of the previous evaluations to enhance the performance. Here, we show that the number of evaluations required for convergence to the saddle point can be significantly reduced by making use of an approximate energy surface obtained by a Gaussian process model based on inverse inter-atomic distances, evaluating accurate energy and gradient at the saddle point of the approximate surface and then correcting the model based on the new information. The performance of the method is tested with start points chosen randomly in the vicinity of saddle points for dissociative adsorption of an H2 molecule on the Cu(110) Surface and three gas phase chemical reactions.
Theoretical Examination of Efficiency of Anthocyanidins as Sensitizers in Dye-Sensitized Solar Cells
Authors: Abdulsalami Ibrahim Olasegun , Semire Banjo , Bello Issa Adewale
Published: October 2019

After experimental studies on the application of anthocyanidins as sensitizers in dye-sensitized solar cells (DSSCs) we have used computational methods to further elucidate the data obtained in the experimental study. In this study structural effects and electronic contributions of four anthocyanidins, cyanidin (Cy), delphinidin (Dp), malvidin (Mv) and pelargonidin (Pg), to improve the efficiency of DSSCs were investigated, using quantum chemical method, the density functional theory (DFT), to calculate parameters such as frontier molecular orbitals, band gap energies, reactivity descriptors.
Key conditions of alpha-tocopherol encapsulation in gum Arabic dispersions
Authors: Muhammad Fuad Al Khafiz  , Yuanita Hikmahwati  , Khairul Anam  , Dwi Hudiyanti
Published: October 2019

Alpha-tocopherol or TOC is among substances that has medicinal capabilities. However, alpha-tocopherol is vulnerable to surrounding milieu settings. This leads to the necessity to shield it against unforeseen alterations during the storing or handling procedures. Encapsulation is presented as a procedure which can shield active agents from adverse changes by means of coating with polymers. In this study, gum Arabic (GA), a biopolymer derived from Acacia species, was used as the encapsulation matrix. Encapsulation process was done at different concentrations of GA dispersions (10%, 20%, 30% and 40%) and at various pH levels (5.4, 6.4, 7.4 and 8.4). To evaluate the key conditions of TOC encapsulation in GA dispersion we analysed TOC encapsulation efficiency (EE) and rate of release (RR) from GA dispersions as well as loading capacity (LC) of GA for TOC. The EE, RR and LC were determined by measuring the TOC concentration in the GA dispersions using UV Visible spectrophotometry at 291 nm. Results disclosed that the key conditions for achieving a high LC by GA with high efficiency of TOC encapsulation were in a dispersion of 20% GA at pH range of 6.4 and 7.4. The best EE of TOC and LC of GA were 48% and 2.8%, respectively, with a TOC average RR of 1.05-1.09 ppm/day. The results indicate that gum Arabic is a potential matrix to encapsulate alpha-tocopherol.
Face and content validation of Phacoemulsification Techniques Related To Surgically Induced Astigmatism questionnaire
Authors: Md Muziman Syah Md Mustafa  , Nazaryna Marzuki  , Khairidzan Mohd Kamal  , Noorhazayti Ab. Halim
Published: October 2019

Phacoemulsification surgical techniques are associated with surgically induced astigmatism (SIA) in post-cataract surgery. However, no established tool is currently available to gather information on the surgeon's phacoemulsification techniques. This study aimed to validate a newly developed ‘Phacoemulsification Techniques Related to Surgically Induced Astigmatism’ (PTechSIA) questionnaire. PTechSIA questionnaire was designed to collect information on surgical techniques used by surgeons during phacoemulsification. Questionnaire items were generated based on peer-reviewed literature of related domains to phacoemulsification surgical techniques. The self-administered tool consisted of fifteen close-ended questions. Ten subject-matter experts (SMEs) were recruited for face validation using qualitative approach and content validation using Lawshe’s method. The items in the questionnaire were modified based on feedback from the SMEs. Content validation ratio (CVR) was calculated for each item; items with CVR value of less than 1.00 were eliminated, and the final content validity index (CVI) of the questionnaire was obtained. Out of fifteen items, six items with CVR value of less than 1.00 were eliminated (items number 2, 7, 11, 13, 14, 15) with initial CVI of 0.61. After the modification process, the number of final items was nine, with an overall final CVI score of 1.00. Overall, the finalised PTechSIA questionnaire achieved appropriate validity. Hence, the findings indicate that the PTechSIA questionnaire can be utilized for future assessments of surgical techniques and its association with SIA.
Hepato & nephro protective effects of naringenin-loaded tpgs polymeric nanosuspension against cisplatin-induced toxicity
Authors: Sumathi Rajamani  , Gobinath Kalyanasundaram  , Tamizharasi Sengodan  , Sivakumar Thangavelu  , Nikhitha K Shanmukhan  , Arun Radhakrishnan
Published: October 2019

Cisplatin (Cis-Diammineplatinum (II) dichloride/CIS) is one of the most potent chemotherapeutic agents widely used in treatment of various cancers. Naringenin (NAR), a natural flavonoid, protect against CIS-induced injury in rats without hampering CIS beneficial cytotoxic activity. Even though NAR exhibits therapeutic potency, clinical evolution of the molecule is embarrassed because of very less aqueous solubility which corresponds to low availability at the site of the tumor. In our former analysis, nanosuspension of naringenin (NARNS) was developed by the method of high-pressure homogenization. The study had been continued to evaluate the protective role of D-α-Tocopheryl polyethylene glycol succinate (TPGS) coated NARNS, against oxidative stress-induced hepato and nephrotoxicity in male Wistar rats upon CIS treatment. Induction of acute hepato and neprotoxicity was done by intraperitoneal injection (i.p) injection of CIS (7 mg/kg of body weight) and administration of NAR and NARNS. Administration of NARNS virtually suppressed CIS-induced and liver injury evidenced by a reduction of lipid peroxidation level, blood urea nitrogen, serum uric acid, creatinine and elevated enzymatic antioxidant activities of superoxide dismutase, catalase, and glutathione peroxidase in rats liver tissue. Histological studies substantiated the biochemical parameters. The study suggests that NARNS has strong hepato and nephroprotective effect compared to NAR.
A study to evaluate and assess the antibiotic prescription pattern for the surgical prophylaxis to prevent post-operative wound infection (SSI) in a tertiary care hospital
Authors: Kisshore Kumar G  , Preethy R  , Srinivasan V
Published: October 2019

Surgical site infection is a major complication following surgery affecting up to 50 % of operated patients which can be prevented by appropriate antibiotic prophylaxis. Hence this study aims to investigate the pattern of the prophylactic antibiotic usage in patients undergoing elective surgery and to assess the percentage of drugs included in the National List of Essential Medicines (NLEM). This is a Prospective study conducted at Saveetha Medical College and Hospital from April 2018 to April 2019 included medical records of 1093 Patients above 18yrs of age including both sex (male and female) who has undergone elective surgery in Department of General Surgery. Patient's demographic data and comorbidities was also collected and verified for antibiotic prophylaxis, i.e. choice and duration of antibiotics, time of administration, intra-operative dosing, choice and duration of the postoperative use. Pediatrics, Neonatal Surgeries, Pregnant and lactating women were excluded from this study. The obtained data was analyzed, and conclusions were drawn with the help of SPSS analysis software. The results shows Third-generation cephalosporin's injection Taxim (Cefotaxime) was mainly used preoperatively in 486(44.46%) patients by intravenous route followed by cefixime-191(17.47%),ciprofloxacin-161(14.73%). In addition,458(41.90%) patients received either Inj.TT or Metronidazole along with the 1st pre-operative drug. The antibiotics were administered in 2 doses (i.e.) overnight dose and other dose is given just half an hour prior to surgery. No intraoperative redosing was given. The duration of the postoperative prophylaxis was extended to 3 days to 5 days in all 1093 cases. SSI was identified in 25 cases, and overall incidence in our study is 2% which is quite compatible with other studies and incidence is common among patients with age-related risk factors and comorbidities. This study revealed that third-generation cephalosporin Cefotaxime was considered as the main pre and post-operative drug, which is based on surgeon's experience, type of surgery and local antibiotic resistance pattern. Various measures like the development of local hospital Policy, surveillance on SSIs, hospital antibiotic policy, promoting good surgical techniques and strict asepsis in the operating theatre, usage of single antibiotics, and completion of course of antibiotics can prevent the emergence of multi-resistant organisms.
Design of the mirror antenna of a spacecraft with the ultralight high precision size-stable reflector
Authors: Taygin V. B. , Lopatin А. V.
Published: October 2019

The paper discusses the existing design of mirror antennas used on spacecraft. The requirements are formulated under which the reliable performance of antennas is ensured under operating conditions. Innovative construction of the space high frequency axisymmetric mirror antenna of an ultralight class is presented. Antenna’s body consists of several conjugate carbon fiber shells. Antenna’s design technology which gives an opportunity to create the shell of a reflector with minimal deflection from a full-paraboloid is developed. Using the finite element method, a parametric modal analysis of the antenna is performed. Based on this analysis, geometric parameters were determined that provide optimal mechanical and mass characteristics of the structure. The calculation results were used to create a prototype mirror antenna. It is shown that the created antenna possesses the parameters required for generation of the high-directional electromagnetic emission of Q and V frequency domain. Successful ground experimental perfection of the construction of the antenna is made. It included the stages of mechanical, thermal vacuum, and radio engineering tests. The proposed design can be used to create advanced spacecraft.
Adopting BIM Technology in Fall Prevention Plans
Authors: Abed Hayder Razzaq , Hatem Wadhah A. , Jasim Nidal A.
Published: October 2019

Building Information Modeling is a modern technique that has contributed in improvement of construction industries. Early detection of hazards during the life cycle of the project will contribute to protect the working environment from exposure to risks that will affect the time and cost. The changing nature of the sites makes it difficult in identifying the fall risks accurately. Based on BIM 4D simulation, the objective of this study is to create a computer model by using BIM technology to help accurately determine (a) the hazards of falling from the edges (b) the hazards from struck by falling objects, by relying on the opinions of safety experts in identifying potential risks and demonstrating the effectiveness of this technique in facilitating hazards acknowledgment. In this research, Iraqi safety rules and safety rules of OSHA were adopted. The research idea was applied to a school building project under construction as a case study to benefit from the research outputs in improving the safety of school’s buildings projects. The results displayed that the model prepared by the researchers helped the safety managers in understanding the details and sequence of work easily, thus contributed to the precise identification of the falling hazards, use suitable safety equipment for each risk, in addition to the possibility of using this model as a training program for workers in the workplace to help give an idea of the nature of risk which they may be exposed it, increase safety communication and generate time schedule empty from risks. Safety managers believe that this model can contribute to improve workplaces safety and prevent time and cost losses due to reliance on inaccurate methods based on static 2D schemes and sense in risk identification.
ALGILANAN AŞIRI VASIFLILIK VE BİREYSEL KARİYER PLANLAMASI İLİŞKİSİNDE ALGILANAN ÖRGÜTSEL DESTEĞİN DÜZENLEYİCİLİK ETKİSİ
Authors: IŞIK Metin
Published: October 2019

﻿     Bireysel
kariyer planlaması, bireyin kariyeriyle ilgili amaçlar belirlediği ve bu
amaçlara ulaşmak için kullanacağı yol/ları değerlendirdiği bir süreçtir. Bu
süreci etkileyen birçok faktör olmakla birlikte, bunlardan biriside bireyin belirli
iş gereksinimlerini aşan beceri ve eğitime sahip olma düşüncesi olarak ifade
edilen aşırı vasıflılık olgusudur. Öte yandan bireyin çalışma hayatında
sergilediği birçok davranışın arka planında bireyin örgütüne yönelik destek
algısı yatmaktadır. Bu bağlamda, araştırmada algılanan aşırı vasıflılık algısı
ile bireysel kariyer planlaması ilişkisinde algılanan örgütsel desteğin
düzenleyicilik etkisi incelenmeye çalışılmıştır. Bu amaç doğrultusunda nicel
bir araştırma yapılmıştır. Araştırma verileri Bitlis faaliyet gösteren kamu ve
özel sektör çalışanlarından elde edilmiştir. Veriler üzerinde güvenilirlik,
geçerlilik, açımlayıcı ve hiyerarşik regresyon analizleri yapılmıştır. Yapılan
analizlerde, algılanan örgütsel desteğin, algılanan aşırı vasıflılık ve
bireysel kariyer planlaması ilişkisinde düzenleyici bir etkiye sahip olduğu
tespit edilmiştir. Ayrıca kontrol değişkenlerinden eğitim durumunun da
düzenleyici bir etkiye sahip olduğu ortaya çıkmıştır. Araştırmanın literatüre
katkı sunmasının yanı sıra işletme yöneticilerine de yol göstermesi
beklenmektedir.
TÜRKİYE'DE PARA POLİTİKASININ ÖDEMELER BİLANÇOSUNA ETKİSİ:2003-2015
Authors: KOÇ Sebahattin , GÖVDERE Bekir
Published: October 2019

﻿Bu çalışmanın temel amacı, Türkiye ekonomisi için para
politikasının ödemeler dengesi üzerindeki etkisini analiz etmektir. Çalışmada analiz
dönemi olarak 2003-2015 yılları seçilmiştir. Değişken olarak reel efektif döviz
kuru, reel faiz oranları, M2 para arzı, kredi hacmi, büyüme oranları ile cari
işlemler dengesi kullanılmıştır. Çalışmada serilerin durağanlığını test etmek
amacıyla ADF (Augmented Dickey-Fuller) birim kök testi kullanılırken; etki-tepki
fonksiyonları, Varyans ayrıştırması ile VAR analizi gerçekleştirilmiş ve
nedenselliğin tespitinde Granger nedensellik testi uygulanmıştır. Nedensellik
testi sonuçlarına göre; cari açıktan reel efektif döviz kuru, reel faiz
oranları, M2 para arzı ve kredi hacmine doğru tek yönlü bir nedensellik tespit
edilmiştir. Ayrıca büyüme oranından cari işlemler açığına doğru tek yönlü bir
nedensellik söz konusudur. Cari açıktaki değişikliğin nedenleri olarak sırasıyla
büyüme oranları, reel efektif döviz kuru, reel faiz oranları ve kredi hacmi varyans
ayrıştırması ile tespit edilmiştir.
VERGİ DENETİMİNDE YENİ BİR YAKLAŞIM OLARAK BLOK ZİNCİRİ TEKNOLOJİSİ
Authors: DEMİRHAN Habip
Published: October 2019

﻿Vergi tarih boyunca kamu harcamalarının finansmanında
devletin en önemli enstrümanlarından biri olmuştur. Devletin en önemli
finansman aracı olan verginin denetimi ekonomik, sosyal ve hukuki nedenlere
dayanmaktadır.  Beyan esasına dayalı bir
vergi sisteminde ortaya çıkacak aksaklıkları gidermede güçlü bir denetimin
etkisi yadsınamayacak derecede önem arz etmekte ve bu konudaki en önemli görev
bu alanda çalışanlara düşmektedir. Vergi denetiminin işlevi, vergi idaresinin
ve mükelleflerin yasal mevzuata uygun olarak hareket etmelerini temin etmektir.
Bunun için de verimli, etkin, şeffaf ve hesap verebilir bir vergi denetiminin
varlığı önem arz etmektedir. Son yıllarda gelişen Bilgi ve İletişim
Teknolojileri ile birlikte kamu yönetim yapılarında e-uygulamalar giderek
artmaya başlamıştır.  Çalışmada, son
yıllarda sıkça zikredilen blok zinciri uygulamaları çerçevesinde vergi
denetiminin geleceği değerlendirilmiştir. Blok zincirinin gelecekte diğer
alanlarda olduğu gibi vergi denetiminde de ciddi derecede etkili olacağı, vergi
tahsilatının hızlı bir şekilde yapılmasını ve kayıt dışılık ile mücadele etkin
bir rol alacağı sonucuna varılmıştır.
Aktivitas Ekstrak Etanol 70% Biji Nangka (Artocarpus heterophyllus Lam.) dalam Penurunan Kadar Gula Darah Tikus Diabetes Gestasional Yang Diinduksi Streptozotocin
Authors: Dwitiyanti Dwitiyanti , Efendi Kriana , Rachmania Rizky Arcinthya , Septiani Riri
Published: October 2019

Biji Buah Nangka (Artocarpus heterophyllus L.) dilaporkan memiliki aktivitas sebagai antihiperglikemia. Pada penelitian ini bertujuan menguji ekstrak etanol 70% biji nangka dan diharapkan dapat dimanfaatkan sebagai penurun kadar gula darah tikus diabetes gestasional yang diinduksi streptozotocin. Hewan uji tikus betina bunting galur Sprague dawley dibagi 6 kelompok perlakuan, masing-masing terdiri dari 4 ekor tikus. Kelompok I (kontrol normal), kelompok II (kontrol negatif), kelompok III (kontrol positif) diberi metformin dosis 51.37 mg/kgBB, kelompok IV (Dosis Uji 100 mg/kgBB), kelompok V (Dosis Uji 200 mg/kgBB) dan kelompok VI (Dosis Uji 400 mg/kgBB), kelompok IV,V dan VI diberi sediaan uji biji buah nangka secara oral. Tikus diinduksi terlebih dahulu dengan streptozotocin agar tikus mengalami hiperglikemia, kemudian diberi perlakuan sediaan uji selama 14 hari. Pengambilan darah dilakukan pada hari ke-14, untuk menghitung kadar glukosa darah menggunakan fotometer klinikal. Hasil uji ANOVA satu arah menunjukkan adanya perbedaan antar kelompok perlakuan. Semua kelompok sediaan uji ekstrak biji buah nangka memiliki aktivitas menurunkan kadar glukosa darah terhadap tikus diabetes gestasional. Hasil uji Tukey penurunan kadar glukosa darah menunjukan kelompok uji sediaan biji nangka dosis 400 mg/kg BB sebanding dengan kelompok positif yang diberikan Metformin  51.37 mg/kgBB.
Ticari Havayolu Taşımacılığı Sektöründe Makine Öğrenmesi Uygulamalarının İncelenmesi
Authors: ŞEKERLİ Eyüp Bayram
Published: October 2019

Karmaşıklığın oldukça fazla olduğu, dinamik bir çevrede
operasyonlarını sürdüren havayolu işletmelerinin birçok kısıta rağmen doğru
karar almaları oldukça önemlidir. Bugün çok çeşitli veri ve büyük miktarda veri
üreten havayolu işletmelerinin bu verileri en doğru şekilde değerlendirebilme
becerileri kararlarının etkinlik derecesini belirleyebilecektir. Bu nedenle, bu
çalışma kapsamında Yapay Zeka (YZ) uygulaması olan Makine Öğrenmesinin (MÖ)
havayolu işletmelerinin hangi süreçlerinde, hangi algoritmalar ile
kullanılabileceği alanyazında yer alan çalışmalar incelenerek tespit edilmeye
çalışılmıştır. Elde edilen sonuçlar, özellikle son yıllarda MÖ’nün “dispeç
güvenilirliği”, “uçuş emniyeti”, “gelir yönetimi/fiyatlama” ve “müşteri davranışları”
konularına uygulanmasında bir artış olduğunu ortaya koymaktadır.azarlarına aittir.
PENGARUH PENERAPAN IFRS, AUDIT EFFORT, DAN KOMPLEKSITAS OPERASI PERUSAHAAN TERHADAP AUDIT DELAY
Authors: Wijayanti Santi , Effriyanti Effriyanti
Published: October 2019

This study aims to test and prove empirically the influence of IFRS implementation, audit effort and complexity of company operations. This research was conducted at a jasa real estate company listed on Indonesia Stock Exchange (BEI) in 2009-2017. The sample in this research by purposive sampling method. Research type is quantitative with quantitative descriptive method, obtained 9 companies that used as research sample with observation for 9 (nine) year, so total observation is 81 financial report which have been audited. The analysis method used is descriptive statistics, data quality test and hypothesis test with significance level of5%. The results of this study indicate that the application of IFRS has no significant effect on audit delay, while audit effort has no effect on audit delay and the company's operating complexity has no significant effect on auditdelay
PENGARUH PRINSIP-PRINSIP GOOD GOVERNANCETERHADAP KINERJA PEMERINTAH DAERAH PADA BADAN PENGELOLA PAJAK DAN RETRIBUSI DAERAH KABUPATEN MUSI RAWAS
Authors: Sunardi Sunardi , Yanti Darma , Ariansyah Wendi
Published: October 2019

Rumusan masalah dalam penelitian ini adalah bagaimanakah pengaruh prinsip-prinsip good governance terhadap kinerja pemerintah daerah. Tujuan penelitian ini adalah untuk mengukur pengaruh prinsip-prinsip good governance terhadap kinerja pemerintah daerah pada Badan Pengelola Pajak dan Retribusi Daerah Kabupaten Musi Rawas. Penelitian ini merupakan jenis penelitian asosiatif. Data yang digunakan dalam penelitian ini adalah data primer. Penelitian ini menggunakan sampel, sampel yang digunakan sebanyak 34 responden. Analisis data yang digunakan dalam penelitian ini adalah analisis kualitatif dan analisis kuantitatif. Hasil dari penelitian ini menunjukkan bahwa prinsip-prinsip good governance secara signifikan berpengaruh positif terhadap kinerja pemerintah daerah pada Badan Pengelola Pajak dan Retribusi Daerah Kabupaten Musi Rawa
Determinants of The Effectiveness Of Implementation Performance Based-Budgeting and Budget Absorption in Local Governments
Authors: Friyani Rita , Hernando Riski
Published: October 2019

This study aims to try to examine the influence of Local Government Employee Understanding, Training, and External Pressure (Determinants) on the Effectiveness of Implementation Performance-Based Budgeting and Budget Absorption in Local Governments (Study on Jambi City Government). The population is all Dinas and SKPD in Jambi City Government. The sampling technique uses a purposive sampling approach. The criteria used are those involved in performance-based budgeting and budget execution practices. So, that the total sampel used was 60 people. Data were obtained by questionnaire distribution techniques to respondents throughout the Dinas and SKPD in Jambi City Government. Data analysis using SEM PLS. The results of data processing found that training, understanding, education and external pressure had a positive effect on the effectiveness of performance-based budget implementation and budget absorption.