bluuebunny/crossref_metadata_2025 huggingface dataset:
El aporte de las colecciones osteológicas documentadas: líneas de investigación en la Colección “Prof. Dr. Rómulo Lambre” (La Plata, Argentina)
Authors: Plischuk Marcos , Garizoain Gonzalo , Petrone Selene , Desántolo Bárbara , García Mancuso Rocío , Salceda Susana , Inda Ana María
Published: September 2020

Las colecciones osteológicas documentadas contribuyen a resolver problemas en la bioantropología desde su particular aporte a partir de la combinación de rasgos esqueléticos e información individual. Es por esto que posibilitan la generación de métodos estandarizados para la caracterización biológica de los individuos y permiten el análisis de características anatómicas, histológicas y patológicas desde una perspectiva poblacional, considerando su contexto socio-histórico. En el año 2005 en la Facultad de Ciencias Médicas (Universidad Nacional de La Plata, La Plata, Argentina), a fin de formar una colección documentada regional, se integró la Colección Osteológica Prof. Dr. R. Lambre a partir de restos esqueletéticos donados por el Cementerio Municipal La Plata (CMLP). Dichos restos provienen de cadáveres no reclamados, destinados a cremación u osario y exhumados por personal de la institución. La Colección está compuesta en la actualidad por 435 individuos con información documental asociada, (58,16% de sexo masculino y 41,84% de sexo femenino), con edades de muerte desde nonatos a 101 años, mientras que las fechas de muerte abarcan el período 1900-2003. Este artículo tiene como propósito describir las líneas de investigación desarrolladas en la colección Lambre desde su conformación y los principales resultados alcanzados. Para esto, se describen las tareas realizadas en relación con la caracterización biológica de individuos subadultos a partir de su esqueleto, se detallan los análisis histológicos en hueso y diente, principalmente enfocados en los métodos de estimación de edad de muerte, se comentan los estudios realizados en antropología dental, y finalmente, se describe el análisis osteopatológico. Se destacan tres aportes específicos hacia la bioantropología. En primer lugar, el aporte académico en la generación de conocimiento acerca de la variación histomorfológica del esqueleto durante la ontogenia. En segundo lugar, la formación de recursos humanos; el trabajo en la colección permitió la consolidación de un equipo interdisciplinario que se constituyó como formador de formadores en la investigación científica, docencia y extensión. Por último, y principalmente durante los últimos años, el incremento de transferencia de los resultados hacia organismos gubernamentales y no gubernamentales.
Starość w starzejącej się Europie
Authors: Krajewski Piotr
Published: September 2020

The development of relationships between young people and the generation of the grandparents must be accompanied by a sense of solidarity and the need to share experiences, especially in the family circle. In this way, young people are slowly gaining experience in finding thread of understanding and creating relations with other people from the atomising population. Mutual understanding and keeping good relations between the generations also prevents the isolation and marginalization of the older generation; then the young people do not see any interest to „help” them in this. Today we can observe with concern how the culture of the nations living with the present moment is getting exhausted and disappears because the individual gradually is losing its connection with family members and the roots of its own history. After all, the older people are able to offer invaluable assistance to young people, they can be and should be the trustees of the past and all these things in order to prevent a young generation from forgetting traditions, customs, art, religion, music, culture, and crafts of their fathers.
Propozycja zrównoważonego rozwoju w myśli naukowej Profesora Stefana Kozłowskiego
Authors: Skowroński Antoni
Published: September 2020

The article is connected with the life and scientific works of Professor Stephen Kozlowski died in September 2007. He was a great research scientist working with the geology of raw materials and then with the conservation and formation of natural environment. Last 25 years of his scientific work he was engaged in the creation of the concept of sustainable development and in the promotion of the concept in Polish social, economic and political life. Using the term “sustainable development” he meant all the activities which improve man’s life conditions and which do not cause the degradation of natural environment. Such effect can be obtained by equalizing of three development vectors: natural, economic and cultural. He proposed that Poland should adapt the economic progress to natural conditions of environment. He said that the idea of the sustainable development being based on the foundations of ecological era had all chances to make a success in our conditions of weather, soil, water and raw minerals.
Realizacja przez administrację publiczną odpowiedzialności w ochronie środowiska
Authors: Jabłoński Maciej
Published: September 2020

Environmental protection is an area of interdisciplinary, in which the rule is the use of concepts relevant to the legal sciences, natural sciences, engineering, or chemical. Therefore, in practice, they may mean different things depending on the conceptual context in which they are used. The concept, which draws attention to the rights and duties of citizens, public authorities, or environmental organizations, is a responsibility in protecting the environment. The state authorities should support citizens in their efforts to protect and improve the environment. Ecological safety, which is to be provided by a public authority is a state of the environment that allows you to safely stay in it and use it. The instrument to ensure that safety is the protection of the environment, which acts as a directive interpretation when there are doubts as to the scope of duties, such duties, and how they are implemented.
Znaczenie prawa ochrony środowiska
Authors: Karski Leszek
Published: September 2020

This article addresses the concept of environmental law. The paper begins with a general background on the justification for the study of environmental law. The second section focuses on the nature of law. In the next section the author analyses legal definitions of environmental protection and environment. As the analysis shows that environmental legislation plays a crucial role, the final section discusses its location in the Polish legal system. This study highlights that environmental law should be treated as a branch of law.
Stanowienie oraz stosowanie polityki ekologicznej przez administrację publiczną w Polsce oraz Unii Europejskiej
Authors: Jabłoński Maciej
Published: September 2020

Environmental protection is a field of law about interdisciplinary character, which using notions typical of legal, natural, technical, or chemical theories is a rule in. Therefore in practice, they can have the notional various meaning depending on the context they stayed in which used. A notion which is paying attention to the rights and duties of citizens, bodies of a public authority or also environmental organizations, is an ecological politics.
Zmienność osobnicza a dynamika metapopulacji: model osobniczy
Authors: Uchmański Janusz
Published: September 2020

The individual-based model is presented for describing the dynamics of metapopulations. The model of the local population describes the dynamics of the population with non-overlapping generations. The growth of the individuals is followed in every generation. The growth rate of individuals is affected by the level of resources. The individuals compete for these resources, which are therefore not evenly distributed among the individuals. The persistence of a local population in which the individuals could not disperse was compared to the persistence of the metapopulation. Metapopulation models differed in the conditions under which individuals disperse. In some versions of the model the individuals that dispersed were the weaker individuals in the local population - they dispersed because they could not acquire any resources in the original local habitat, or because they could not acquire enough resources to reproduce. In another version, the individuals that dispersed were the stronger individuals. They migrated immediately before the extinction of the local population. In the last version of the model, the dispersing individuals were selected at random. The model showed that the reason for which the individuals dispersed affected the persistence of the metapopulation. In contrast to classic models, one cannot assume that dispersion could be adequately described in terms of the diffusion equation. The effect of the reproduction rate and the variability of the individuals in the population on the persistence of different version of the metapopulation model was also analyzed.
The Effect of Probiotics Supplementation on Maternal-Fetal Care
Authors: Mardani Mahnaz , Rezapour Sadegh
Published: September 2020

Pregnancy-related complications can have long-term effects on mothers and fetus/child.
Microbiome within the human gut is an important factor in maintaining optimum health during
pregnancy and possibly reduces the incidence of these complications. Probiotics are active living
microorganisms that can provide the host with health benefits such as; immune and hormonal regulatory
and metabolic benefits when administered in adequate and optimum dose. Probiotic supplementations
also regulate an abnormal and unbalanced microflora population that can control the
pathogenesis of several diseases like obesity and diabetes. Probiotics also play a protective role in
complications like preeclampsia, gestational diabetes mellitus and maternal weight gain and enhance
successful outcomes of reproduction. This mini-review summarizes the maternal and fetal
effects of probiotics during pregnancy.
A Review on Catastrophic Evolution of SARS-CoV to SARS-CoV2: A Global Pandemic
Authors: Krishnan Sushmita , Subramanian Darshini , Rajamani Sri Sakthi Priyadarshini
Published: September 2020

:

The coronaviruses, belonging to the family Coronaviridae, have caused a massive pandemic
in December 2019 after their previous outbreaks as SARS-CoV and MERS. The outbreak is believed to
have originated from the seafood and live market in the Hubei province of China. The Rhinolophus
species are the natural hosts of this virus. This virus caused pneumonia and took away many lives before
it was recognized as the novel Coronavirus. Very little information is available about the biology
and nature of the novel Coronavirus. This article reviews multiple aspects encompassing its origin, epidemiology,
pathogenesis, symptoms, and the global statistics of spread. Acute respiratory distress syndrome
(ARDS) is the key symptom of this condition. Angiotensin-converting enzyme 2 (ACE2) helps
in the penetration of the virus into the target cells. Deeper research and understanding are essential for
the identification of antibodies that inhibit ACE2 and can prevent viral replication. Drug design and
control of disease are crucial. In countries like India, where plant diversity is extensive, it is prudent to
focus on plant-based alternative drugs. Many attempts have been made to review and curate the drug
discovery attempts using immuno-informatic and bioinformatic tools.
From the Editor - May 2009
Authors: Stark Ernie
Published: September 2020

A letter from the editor.
The Impact of Human Resource Development on Organisational Performance: Test of a Causal Model
Authors: Katou Anastasia A.
Published: September 2020

Although a number of studies have recognized the relationship between human resource development (HRD), and organisational performance, the mechanisms through which HRD leads to organisational performance remain still unexplored. The purpose of this paper is to investigate the pathways leading from HRD to organisational performance by using structural equation modelling. Specifically, we used this analytical tool to test a research framework that is constituted by a set of causal relationships between organisational and other contingencies, resourcing and HRD, skills, attitudes and behaviour, and organisational performance. Employing data from organisations operating in the Greek manufacturing sector, results indicate that the impact of HRD on organisational performance is positive and serially mediated through skills, attitudes and behaviour, and moderated by resourcing, organisational context and other contingencies. Thus, the paper not only supports that HRD has a positive impact on organisational performance but also explains the mechanisms through which HRD improves organisational performance.
Developing a Blockchain-Based Supply Chain System for Advanced Therapies: Protocol for a Feasibility Study
Authors: Lam Ching , van Velthoven Michelle Helena , Meinert Edward
Published: September 2020

Background

Advanced therapies, including cell and gene therapies, have shown therapeutic promise in curing life-threatening diseases, such as leukemia and lymphoma. However, these therapies can be complicated and expensive to deliver due to their sensitivity to environment; troublesome tissue, cell, or genetic material sourcing; and complicated regulatory requirements.

Objective

This study aims to create a novel connected supply chain logistics and manufacturing management platform based on blockchain, with cell and gene therapy as a use case. Objectives are to define the requirements and perform feasibility evaluations on the use of blockchain for standardized manufacturing and establishment of a chain of custody for the needle-to-needle delivery of autologous cell and gene therapies. A way of lowering overall regulatory compliance costs for running a network of facilities operating similar or parallel processes will be evaluated by lowering the monitoring costs through publishing zero-knowledge proofs and product release by exception.

Methods

The study will use blockchain technologies to digitally connect and integrate supply chain with manufacturing to address the security, scheduling, and communication issues between advanced therapy treatment centers and manufacturing facilities in order to realize a transparent, secure, automated, and cost-effective solution to the delivery of these life-saving therapies. An agile software development methodology will be used to develop, implement, and evaluate the system. The system will adhere to the EU and US good manufacturing practices and regulatory requirements.

Results

This is a proposed study protocol, and upon acceptance, grant funding will be pursued for its execution in 2021.

Conclusions

The successful implementation of the integrated blockchain solution to supply chain and manufacturing of advanced therapies can push the industry standards toward a safer and more secure therapy delivery process.

International Registered Report Identifier (IRRID)

PRR1-10.2196/17005
Resilience and Leadership Effectiveness
Authors: , Ph.D. Léo Bruno
Published: September 2020

The study sought to evaluate the resilience profile, the predominant leadership styles, the leadership effectiveness, and the relationship between the resilience factor and leadership effectiveness of a group of executives. In order to evaluate the resilience profile a closed instrument of Likert type has been developed and applied. To identify the predominant leadership styles, as well as the leadership effectiveness of the involved executives, it has been used an instrument available in the market. To verify the relationship between resilience factor and leadership effectiveness, it has been used the linear regression method computing the linear correlation coefficient between the before mentioned variables, involving 100 executives. The study has shown that the executives have a moderate resilience level in their resilience profile, with predominance of self-efficacy and reaching out. Additionally the study has uncovered lack of flexibility regarding the leadership styles, presenting styles of selling and sharing ideas as dominants. The study also showed that the leadership effectiveness of the involved executives was at a moderate level. Finally, the research pointed out a high positive relationship between executives resilience factor and leadership effectiveness.
Stella’s Choice - Re-read A Streetcar Named Desire
Authors: Pei GAO
Published: September 2020

Tennessee Williams’ A Streetcar Named Desire reveals Blanche’s tragic fate in the period of social change from the perspective of sexual conflict, and reveals the contest between the declining traditional civilization of the South and the emerging industrial civilization in American history. The play renders symbolism to show incisively and vividly the collision between the industrial civilization of the north and the planting civilization of the south, as well as the collision between personal fantasy and the reality of that time. In order to highlight the theme better, the writer skillfully uses various symbolic techniques to make the tragic fate of the heroine full of strong appeal, thus successfully deducing the tragedy of the fall of modern society.
STUDENTS’ KNOWLEDGE AND RISK OF COMMITTING MEDICATION ERRORS IN TWO SCHOOLS OF PHARMACY IN NIGERIA
Authors: CM UBAKA , C EKWE , A ISAH , AB MUKHTAR , CV UKWE
Published: September 2020

Objective: The aim of this study was to determine the knowledge of prescription errors, the certainty of such knowledge, and the risk of committing medication errors among pharmacy students in two universities in Nigeria.

Methods: This study was a cross-sectional comparative survey between pharmacy students of two universities in Nigeria: University of Nigeria, Nsukka (UNN) and Nnamdi Azikiwe University (NAU), Awka. Study variables were measured using four simulated prescriptions and questionnaires. Chi-square test, independent t-test, and ordinal regression analyses were used to assess study outcomes.

Results: A total of 339 pharmacy students (239 in UNN and 100 in NAU), with a mean age of 24 (2.8) years and 57.2% (n=194) male students, participated in this study. Their accurate knowledge of each of the prescriptions were 294 (86.72%), 166 (48.97%), 199 (58.70%), and 248 (73.16%) for prescriptions with error of drug allergy, error of drug interaction, no error, and wrong dose of a drug, respectively. Students from UNN were more likely to commit a statistically significant high risk of error compared to NAU students in prescriptions with a drug allergy and wrong dose, while students in the 4th year class had a statistically significant higher odds of committing a drug interaction prescription error compared to final year students.

Conclusion: Pharmacy students evaluated in this study had good knowledge of medication error detection. The risk of these pharmacy students committing a prescription error was evident in nearly all prescriptions tested and the students’ school was the major predictor of these risks.
CORONAVIRUS DISEASE 2019, DENGUE HEMORRHAGIC FEVER, AND THE CLINICAL SIMILARITY
Authors: SURYANA KETUT
Published: September 2020

Recently, coronavirus disease-19 (COVID-19) case is increasing in Indonesia, simultaneously with the outbreak of dengue hemorrhagic fever (DHF). DHF is generally observed to rise at the beginning of the year that peaks between March and April due to the rainy season and high temperatures. The outbreak of COVID-19 started in Wuhan, China, since December 2019, and it has spread quickly worldwide as a pandemic. COVID-19 and DHF have had comparable clinical indication, laboratory highlights, and it has serious implications for the patients as well as for the general health. Therefore, to distinguish, all the doctors in the primary health care have to be aware and to work carefully.
SPECTROPHOTOMETRIC DETERMINATION OF CEFPIROME IN PHARMACEUTICAL PREPARATION
Authors: CHAFLE DILIP M
Published: September 2020

Objective: A simple, sensitive and precise visible spectrophotometric method has been proposed for the determination of cefpirome (CFM) in pure and oral injectable dosage form.

Methods: A spectrophotometric method is based on the formation of stable red color product by oxidation of drugs by ferric nitrate and subsequent complexation with 1, 10 – phenanthroline with maximum absorption at 515 nm.

Result: The red color complex was formed between Fe (II) and 1, 10 – phenanthroline after reduction of Fe (III) to Fe (II) in the presence of CFM drug. The phosphoric acid solution was used only for quenching the complex formation reaction. Several parameters such as the maximum wavelength of absorption, the volume of reagents, sequence of addition and effect of temperature and time of heating were optimized to achieve high sensitivity, stability and reproducible results. Under the optimum conditions, linear relationship with good correlation coefficient (0.994) was found over the concentration range from 0.20 to 6.00 μg/mL with a molar extinction coefficient 7.7813 × 104 L/mol/cm, limit of detection 0.2026 and limit of quantification 0.6141 μg/mL, respectively.

Conclusion: The proposed method was evaluated statistically for linearity, accuracy, and precision in terms of standard deviation, percentage recovery, percentage error and relative standard deviation. The proposed method can be applied for the routine estimation of CFM in the laboratory.
ANTIMICROBIAL POTENTIALS OF SOIL FUNGI METABOLITES, MOLECULAR DYNAMICS AND THEIR 3D PROTEIN STRUCTURAL PREDICTION USING BIOINFORMATICS TOOL
Authors: O. N. MAJOLAGBE , D. A. AINA , I. O. OMOMOWO , A. THOMAS
Published: September 2020

Objective: To determine the antimicrobial potentials of secondary metabolite of soil fungi and predict their 3D structure and molecular identity.

Methods: Pure soil fungi were isolated from soil samples and cultured under submerged fermentation (Smf) for their metabolites using Potato Dextrose Agar and Broth. The secondary metabolites of the isolated fungi were obtained intracellularly after 21 d of incubation in a rotary shaker incubator. The antimicrobial potentials of the metabolites were investigated against four (4) clinical isolates, namely: Staphylococcus aureus, Klebsiella spp, Candida albicans and Escherichia coli. These soil fungi were further characterized to the molecular level and their evolutionary relationships established using bioinformatics tools. Protein structure of each of the fungi isolates was predicted using PHYRE-2.

Results: Out of all the soil fungi isolated, the metabolite of Aspergillus aculeatus showed the highest antimicrobial activities against Staphylococcus aureus (23.00±2.34 mm), Escherichia coli (9.00±1.44 mm) and Klebsiella spp (24.00±3.45 mm). The 3D protein structure predicted showed that each of the organisms consists of different amino-acid compositions such as: serine, tyrosine, proline, arginine, glycine, phenylalanine leucine with other notable biological properties.

Conclusion: The work revealed that secondary metabolites of the isolated fungi carry an important role in combating infectious agents thereby, providing roadmaps for the biosynthesis of many synthetic and semi-synthetic drugs and bio-products which are environmentally friendly.
DEVELOPMENT AND VALIDATION OF UV-SPECTROSCOPIC METHOD FOR ESTIMATION OF IPRATROPIUM BROMIDE IN API AND IN PHARMACEUTICAL DOSAGE FORM
Authors: SHINDE BHAGYASHRI S. , KALSHETTI M. S. , KOKANE ANJALI P.
Published: September 2020

Objective: To developed and validated UV spectrophotometric method for the estimation of ipratropium bromide in API and pharmaceutical formulation.

Methods: Methanol is used as a solvent and the absorbance of the drug was measured at absorbance’s maxima of ipratropium bromide max is 214 nm.

Results: Maximum absorbance obtained in 214 nm. Calibration curve plotted in concentration range 20-120 µm/ml exhibit the linearity relationship with line equation y=.0.0091x+0.1503 The Accuracy was found to be 99.7-100.2%, the precision %RSD= 0.08613-0.2668, and the LOD and LOQ is 6.33, 19.19. The method was found to comply all the validation parameters as per the ICH guideline indicating the sensitivity of the method analyte.

Conclusion: This method is used as satisfactory for the routine analysis of ipratropium bromide in API and pharmaceutical dosage forms.
ISOLATION AND PURIFICATION OF APIGENIN FROM ALLIUM FISTULOSUM
Authors: V. TEENA MAGLINE IMMACULATE , P. SHLINI , H. MARY CLARE
Published: September 2020

Objective: The objective of this study is to optimize the extraction of apigenin (4′, 5, 7-trihydroxy-flavone) from Allium fistulosum.

Methods: The present study aims at extracting flavonoids from the plant using methanol as a solvent. Phytochemical screening was performed to analyse the phytochemical constituents present in the extract. Apigenin was isolated from the leaves of A. fistulosum and further purified and identified by TLC and HPLC.

Results: Phytochemical screening showed the presence of various constituents like terpenoids, tannins, flavonoids, reducing sugars, phenolics, cardiac glycosides and amino acids. TLC results indicated the presence of apigenin in the plant extract with the Rf value of 0.88, which coincided with the standard apigenin of Rf value 0.83. HPLC results showed a similarity in the peak of 17.1 min of the standard with the minor peak of 17.324 min of the sample. This proved the presence of apigenin in low quantities.

Conclusion: This present study suggests that Allium fistulosum can be a moderate source of apigenin. This compound was isolated for the first time from this plant.
Снижение уровня ошибок при передаче высокочастотных оптических сигналов в условиях турбулентной атмосферы за счет использования статистики уровня приемного сигнала
Authors: Керносов М.Ю. , Кузнецов С.Н. , Огнев Б.И. , Паршин А.А.
Published: September 2020

Анализ распределения вероятности принимаемого сигнала в беспроводной оптической линии связи в различных условиях показывает существенную зависимость уровня ошибок в канале связи от уровня стабилизации мощности на приемнике. Существенное отличие статистики уровня принимаемого сигнала от известных распределений не позволяет использовать их для аппроксимации вероятностей больших отклонений уровня сигнала от среднего значения. Предложен алгоритм оценки оптимальности и корректировки уровня стабилизации приемной мощности на основе оценки статистики распределения. Согласно экспериментальным данным предложенный алгоритм существенно снижает уровень ошибок в атмосферном канале связи.
Влияние импульсного освещения на прорастание семян некоторых овощных, масличных и лекарственных растений
Authors: Зеленков В.Н. , Латушкин В.В. , Иванова М.И. , Лапин А.А. , Карпачев В.В. , Кособрюхов А.А. , Верник П.А. , Гаврилов С.В.
Published: September 2020

Представлены результаты комплексного исследования влияния импульсного светового облучения на прорастание семян, рост и урожайность микрозелени растений. Объекты исследования – ​8 овощных, лекарственных и масличных растительных культур. Выдвинуто положение о необходимости разработки дифференцированных режимов светового облучения растений (в частности, периода следования и длительности импульсов). Установлено, что влияние импульсного облучения в значительной степени зависит от генетических особенностей объектов. Обнаружены наиболее благоприятные и худшие режимы облучения по сравнению с темновым проращиванием для повышения урожайности растений. Параметры флуоресценции хлорофилла различаются при облучении импульсным светом в секундном и миллисекундном диапазонах. Анализ суммарной антиоксидантной активности (САОА) зеленой массы (микрозелени) также показал существенные отличия в зависимости от генетической природы растения.
Intersectionality: A Means for Addressing the Needs of Children with Mental Health Issues who are Engaged with the Family Law and Criminal Justice Systems?
Authors: Bergman Jennifer
Published: September 2020

Huge numbers of children in Canada suffer from mental health issues, yet only a fraction gets needed supports and services.  Left untreated, childhood mental illnesses carry serious consequences for children, families, and society as a whole.  This public health crisis is significantly more pronounced for children who are engaged with the family law (child welfare) and youth criminal justice systems (“crossover youth”).  Crossover youth face multiplicative challenges, including disproportionate rates of mental health issues.  In this article, I explore how the failure to provide crossover youth with needed supports and services, and the related dire consequences suffered by these children and society more generally (e.g. deteriorating mental health, repeated engagement in the criminal justice system) is tied to the failure in the family law (child welfare) and youth criminal justice systems to recognize the effects of the intersection of the various challenges and disadvantages (e.g. poverty, racism, instability) experienced by these children. I describe the paradigm of intersectionality, and argue that the adoption of an intersectional approach by the family law (child welfare) and youth criminal justice systems is imperative in order for the legal system to meet its mandate and protect and promote the well-being of these vulnerable children.
L’égalité réelle et la mise en œuvre intégrale du principe de Jordan
Authors: Levesque Anne
Published: September 2020

Cet article porte sur les problèmes et les retards dans la mise à œuvre du principe de Jordan au sein du gouvernement du Canada. Premièrement, l’article passe en survol les allégations de discrimination mises de l’avant par Assemblée des Premières Nations et la Société de soutien à l’enfance et aux familles des Premières Nations dans leur plainte de droits de la personne contre le Canada en ce qui a trait aux conflits de compétence et du manque de coordination entre les différents paliers et ministères de gouvernements et leur impact néfaste sur les enfants des Premières Nations. Deuxièmement, il résume la décision initiale du Tribunal canadien des droits de la personne [TCDP], rendue en janvier 2016, concernant le principe de Jordan. En troisième lieu, l’article examine les problèmes et les retards liés à la mise en œuvre de la décision du TCDP. Quatrièmement, il aborde en détail l’ordonnance de mai 2017 du TCDP obligeant le Canada de prendre des mesures concrètes pour se conformer à sa décision initiale. Dans la cinquième partie, l’article avance la thèse selon laquelle, qu’afin de véritablement assurer l’égalité réelle dans la société canadienne, le Canada doit être plus proactif dans l’identification et la remédiation de ses pratiques discriminatoires. En l’occurrence, la mise en œuvre du « Plan l’Ourson Spirit » au sein du gouvernement canadien offre une voie prometteuse vers la fin des iniquités dans la prestation de services publics pour les enfants des Premières Nations.
Autophagy inhibition enables Nrf2 to exaggerate the progression of diabetic cardiomyopathy in mice
Authors: Admin Ada , Zang Huimei , Wu Weiwei , Qi Lei , Tan Wenbin , Nagarkatti Prakash , Nagarkatti Mitzi , Wang Xuejun , Cui Taixing
Published: September 2020

Nuclear
factor-erythroid factor 2-related factor 2 (Nrf2) may either ameliorate or
worsen diabetic cardiomyopathy. However, the underlying mechanisms are poorly
understood. Herein we report a novel mechanism of Nrf2-mediated myocardial
damage in type 1 diabetes (T1D). Global Nrf2 knockout (Nrf2KO) hardly affected the
onset of cardiac dysfunction induced by T1D but slowed down its progression in
mice independent of sex. In addition, Nrf2KO inhibited cardiac pathological
remodeling, apoptosis and oxidative stress associated with both onset and advancement
of cardiac dysfunction in T1D. Such Nrf2-mediated progression of diabetic
cardiomyopathy was confirmed by cardiomyocyte-restricted (CR) Nrf2 transgenic (Tg)
approach in mice. Moreover, cardiac autophagy inhibition via CR KO of autophagy
related 5 gene (CR-Atg5KO) led to early onset and accelerated development of cardiomyopathy
in T1D, and CR-Atg5KO-induced adverse phenotypes were rescued by additional
Nrf2KO. Mechanistically, chronic T1D leads to glucolipotoxicity inhibiting
autolysosome efflux, which in turn intensifies Nrf2-driven transcription to
fuel lipid peroxidation while inactivating Nrf2-mediated antioxidant defense
and impairing Nrf2-coordinated iron metabolism, thereby leading to ferroptosis
in cardiomyocytes. These results demonstrate that diabetes over time causes
autophagy deficiency, which turns off Nrf2-mediated defense while switching on
Nrf2-operated pathological program toward ferroptosis in cardiomyocytes,
thereby worsening the progression of diabetic cardiomyopathy.
Knowledge and Attitudes towards Dementia among Clinical Years Medical Students at Jazan University: A Cross-sectional Study
Authors: Elmahdy Mona H. , Ajeebi Maryam E. , Hudisy Arwa A. , Madkhali Jnadi M. , Madkhali Athar M. , Hakami Ammar A.
Published: September 2020

Background: The literature suggests that training in dementia among medical students appears to be inadequate. This study aimed to evaluate medical students’ knowledge and attitudes toward dementia. Aim: To assess knowledge and attitudes of Saudi medical students towards dementia. Methods: This cross-sectional study was conducted at College of Medicine, Jazan University, Jazan, Saudi Arabia using a sample of 241 medical students from clinical years (4th, 5th, and 6th). A structured and self-assessment questionnaire was used and included the socio-demographic data and questions related to knowledge and attitudes toward dementia. Data were presented as frequency and percentage, and as mean and standard deviation (SD). Results: A total of 241 participants agreed to take part in our study; 155 (64.3%) of them were females. Only 44 (18.3%) participants stated that they had a good training in dementia (mostly theoretical, 16.6%) and 17 (7.1%) mentioned having an extracurricular course in the subject. Out of 14 questions, participants obtained a mean of 1.49 (SD = 1.48). Regarding attitudes, participants agreed that much can be done to improve the quality of life of patients with dementia and their caregivers, that it is useful to provide the diagnosis of dementia to the family, and that dementia is better diagnosed in specialized service units. Conclusions: The findings of the present study suggest that while medical students generally have positive attitudes toward dementia, they have poor knowledge about the subject. More effort is needed to bridge knowledge gaps in dementia understanding at undergraduate level.
Aplikasi Kendali Optimal Untuk Model Persediaan yang Mengalami Kerusakan pada Persediaan dan Perubahan Tingkat Permintaan
Authors: Andiraja Nilwan , Agustina Dinda
Published: September 2020

Permasalahan kenaikan dan penurunan barang pada persediaan merupakan penelitian yang pernah diteliti sebelumnya oleh Affandi (2015). Tujuan dari penelitian ini untuk mendapatkan persamaan tingkat produksi dan analisa kestabilan tiingkat persediaan barang yang optimal. Oleh karena itu, penelitian ini membahas tentang kendali optimal dari sistem persediaan dengan kasus penurunan barang yang diakibatkan oleh kerusakan dan perubahan permintaan. Untuk mendapatkan tingkat produksi dan analisa tingkat persediaan, pada model ini digunakan teori kendali, Berdasarkan persamaan differensial dinamik dan fungsi tujuan yang diberikan dapat dibentuk persamaan Hamilton dan Lagrange. Kemudian ditentukan produksi dan persamaan tingkat persediaan yang optimal. Fungsi kendali yang telah diperoleh, digunakan untuk menganalisa kestabilan persamaan differensial dinamik. Berdasarkan contoh yang telah diberikan, maka diperoleh bahwa kurva tingkat persediaan menurun dan meningkat pada waktu yang telah ditentukan. Selanjutnya, penelitian ini dapat dikembangkan lebih lanjut dengan merubah tingkat kerusakan dengan eksponensial.
Premi Tahunan Asuransi Jiwa Dwiguna Pada Generali Insurance Group dengan Asumsi Seragam untuk Status Gabungan
Authors: Aprijon Aprijon , Angriani Della
Published: September 2020

Penelitian ini dilakukan pada perusahaan Generali Insurance Group, terletak di Jl. Arifin Ahmad Pekanbaru. Penelitian ini menggunkan metode asumsi seragam untuk menghitung premi tahunan asuransi jiwa dwiguna untuk status hidup gabungan. Untuk menghitung besarnya premi tahunan perlu dihitungterlebih faktor diskon, anuitas hidup awal, premi tunggal dan premi tahunan. Premi dapat dibayarkan secara bulanan, kwartil dan tahunan. Berdasarkan penelitian diperoleh pada setiap kasus, bahwa besarnya premi tahunan asuransi jiwa dwiguna dengan menggunakan asumsi seragam lebih kecil dibandingkan dengan premi tahunan asuransi jiwa yang diperoleh dari perusahaan.
Determinan Matriks Segitiga Atas Bentuk Khusus Ordo 3×3 Berpangkat Bilangan Bulat Positif Menggunakan Kofaktor
Authors: Rahma Ade Novia , Rahmawati Rahmawati , Vitho Ricken Husnudzan
Published: September 2020

Determinan mempunyai peranan penting dalam menyelesaikan beberapa persoalan dalam matriks dan banyak dipergunakan dalam ilmu matematika maupun ilmu terapannya. Salah satu cara sederhana dalam menentukan determinan suatu matriks menggunakan ekspansi kofaktor. Penelitian ini bertujuan untuk menentukan determinan dari suatu matriks segitiga atas bentuk khusus ordo 3×3 dengan mengguanakan ekspansi kofaktor. Dalam menentukan determinan matriks segitiga atas bentuk khusus ordo 3×3 tersebut, terdapat beberapa langkah yang dikerjakan. Pertama perhatikan bentuk pola perpangkatan matrikx segitiga atas bentuk khusus ordo 3×3 pangkat 1 sampai 10. Dan kemudian, membuktikan bentuk umum pola perpangkatan menggunakan metode induksi matematika. Selanjutnya perhatikan bentuk pola determinan dari matriks segitiga atas bentuk khusus ordo 3×3 pangkat 1 sampai 10. Kemudian membuktikan bentuk umum determinan dengan pembuktian langsung. Hasil yang diperoleh adalah didapatnya bentuk umum determinan dari matriks  segitiga atas bentuk khusus ordo 3×3.
NILAI TOTAL KETAKTERATURAN TITIK PADA GRAF SERI PARALEL sp(m,1,3)
Authors: Marzuki Corry Corazon , Laraza Laraza , Aryani Fitri
Published: September 2020

Pada paper ini ditentukan nilai total ketakteraturan titik pada graf seri paralel  untuk . Penentuan nilai total ketakteraturan titik graf seri paralel dilakukan dengan menentukan batas bawah terbesar dan batas atas terkecil. Hasil dari penelitian ini, diperoleh nilai total ketakteraturan titik dari graf seri paralel sp(m,1,3)  adalah sp(m,1,3), untuk .
PENGARUH BLENDED LEARNING TERHADAP MOTIVASI BELAJAR MAHASISWA PADA MATA KULIAH METODOLOGI PENELITIAN JURUSAN PENDIDIKAN EKONOMI FE UNP
Authors: Arlena Afifah , Effendi Z Mawardi , Sofya Rani
Published: September 2020

The purpose of this research is to find out and analyze the influence of blended learning to the  student’s motivation. The method of this research is Ex-posfacto. The population of this research is 50 students who take the Methodology Research Subject in the semester July-December 2017 with the blended learning assembling. The sampel is taken by using sampel total technical. The data of Blended Learning and student’s motivation use the primary data by using the questionnaire. The instrument is tested by using validity and reliability test. The data is analyzed by using description and inductive (inferensial) analyze which is the normality test, homogenitas test and the hypothesis test is analyzed by using the linear regression, determined coefficient and T experiment with the a = 0,05.The result of this research has showed that there has been a significant influence of blended learning to the student’s motivation. It has showed by the significant of 0,000 <0,05. It has indicated that blended learning has contributed to the student’s motivation 37,9% in the methodology Research Subject and for the rest 62,1% might be effected by others factors.The students should be suggested more active in the blended learning lesson to increase their motivation for the better result. Keyword: blended learning and student’s motivation, Methodology Research
Analisis Pengangguran di Kelurahan Gates Nan XX Kecamatan Lubuk Begalung Kota Padang
Authors: Astuti Meza Yulia , Yulhendri Yulhendri , Siwi Menik Kurnia
Published: September 2020

This study aims to analyze unemployment in Kelurahan Gates Nan XX Lubuk Begalung Subdistrict of Padang City which is seen from the aspect of family social status, education, income and time allocation. This research is a qualitative descriptive study. The sampling technique used is purposive sampling. Data collection techniques are observation, interview and documentation. To test the validity of data used Triangulation Technique. The results of this study indicate that unemployed are classified as half-unemployed come from families who have low economy. This can be seen from the work of parents as Fishermen, Merchants, and Daily laborers. Furthermore, many youth drop out and choose to work as fishermen, casual laborers, and fish traders in Gates Nan XX Village with an average income of Rp 50,000 per day and have 3-5 hours working hours per day. Keywords:Unemploymen
PERANAN PENGAWASAN PIMPINAN DAN DISIPLIN KERJA TERHADAP KINERJA PEGAWAI DINAS PENDIDIKAN PROVINSI SUMATERA BARAT
Authors: Marta David Ardi , Cerya Efni , Syamwil Syamwil
Published: September 2020

This study aims to examine: (1) Influence Supervision of Leadership and Work Discipline on Employee Performance,(2) Supervision of Leadership on Employee Performance (3) Influence of Work Discipline on Employee Performance of Education Office of West Sumatera Province. The type of this research was descriptive associative. The population in this study amounted to 276 people. The sampling technique used was Propotional Random Sampling. Data of this research was primary data with research instrument in the form of questionnaire which have been tested for validity and reliability. Further data analyzed by using multiple regression analysis with SPSS. Based on the results of the study, it was advisable Provincial Education Office of West Sumatra to be better again in improving the performance of employees, especially in terms of commitment in the employee to be more improved so that it can be have an impact on the improving employee performance. It then increases Leadership Supervision in comparing employee job results to predefined standards for feedback on the work they undertake. Employee Discipline to be more improved especially in the case of compliance with work standards that is by taking into account the standards and time set by the Education Office of the Province of West Sumatra for work done in line with organizational goals and can be completed in a timely manner. Keywords: Leadership Supervision, Work Discipline and Employee Performance
PENGARUH BRAND IMAGE DAN BRAND TRUST TERHADAP BRAND LOYALTY VASELINE HAND & BODY LOTION PADA MAHASISWA UNIVERSITAS NEGERI PADANG
Authors: Novalia Dini , Rahmidani Rose , Tasman Abel
Published: September 2020

This research aims to know and prove how much the influence ofBrand Image and Brand Trust on Brand Loyaltytoward the studentsat Padang State University.This type of this research is causative. Population of this research werethe students of Padang State University. While the samples were taken as much as 100 respondents using purposive sampling method by Wibisono formula.Kinds of the data (sample) which was used in this research are primary and secondary . The analysis of data (sample) used pathtechnique by using SPSS program version 21.00. The results of this researchshow that: 1) Brand imagedoes not give thesignificant effecttowardbrand trust, 2) Brand imagedoes not give thesignificant effect towardbrand loyalty, 3) Brand trustgives significant effect towardbrand loyalty. Keywords: Brand Image, Brand Trust, and Brand Loyalty
ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI PENDAPATAN PETANI PADI DI KECAMATAN TANJUNG GADANG, KABUPATEN SIJUNJUNG
Authors: Putra Robi Muhardi , Silvia Armida , Siwi Menik Kurnia
Published: September 2020

This study aims to determine and analyze the influence of the amount of production (X1), land area (X2), the price of grain (X3), education (X4) and production costs (X5) on revenues of rice farmers in the district of Tanjung Gadang, Sijunjung . This type of research is descriptive and associative, wherein the data used are primary data in the form of Cross Section. In June 2018, the object of the research is rice farmers in the district of Tanjung Gadang, Sijunjung, with data collection techniques using direct observation, data collection tools using a questionnaire. The sampling method using Stage One cluster sampling method, the total sample in this study were 71 farmers of rice. Analysis of the data used is descriptive analysis and inductive analysis. In inductive analysis, there are several tests which are: (1) Linear Regression Model, (2) Prerequisites Test Analysis, (3) Test F and Test t. The results of this study show that (1) Total production of positive and significant impact on the income of rice farmers, means increasing the number of production will result in increased incomes of rice farmers in the district of Tanjung Gadang (2) The land area but not significant effect on the income of rice farmers, means increasing the land area then it will not have an impact on increasing the income of rice farmers in Tanjung Gadang  (3) Price grain positive and significant impact on the income of rice farmers, It means that the increase in grain prices will result in increased incomes of rice farmers in the district of Tanjung Gadang (4) The education level did not significantly affect the income of rice farmers, increasing educational means it will not have an impact on the decrease in income of rice farmers in the district of Tanjung Gadang (5) Cost of business no significant effect on the income of rice farmers, means increasing the cost of business then it will not have an impact on the decrease in income of rice farmers in the district of Tanjung Gadang, Simultaneously the amount of production, the land area, the price of grain, level of education and business costs affect the income of rice farmers in the district of Tanjung Gadang. Keyword: Rice Farmers' Income, Production, Land, Grain Prices and Education
IMPLEMENTASI KURIKULUM 2013 PADA MATA PELAJARAN EKONOMI DI SMA NEGERI DI KOTAPADANG (TINJAUAN RENCANA PELAKSANAAN PEMBELAJARAN)
Authors: Hanisa Hanisa , Syamwil Syamwil , Susanti Dessi
Published: September 2020

The purpose of this study is to analyze the lesson plans that have been prepared by teacher of economics. The type of this study is descriptive. The population in this study are the lesson plans that have been prepared by teachers of senior high school in Padang city that have nine lesson plans. The sample is selected by using purposive sampling technique, it is schools that have different accreditation values that location in Koto Tangah and Padang Utara. The data collected are lesson plans for 10th grade in second semester. The lesson plans analyzed by using instrument assessment of lesson plan based on the regulation of ministry education Number 22 A Year 2016. The result showed that the completeness of lesson plans that have been categorized very good. Most of lesson plans curiculum 2013 that prepared by teachers based on the regulation of ministry education Number 103 Tahun 2014 and not based on the regulation of ministry education Number 22 A Year 2016. The contents of lesson plans showed that the learning objectives, indicators, learning methods, learning media, learning resources, and learning steps have “very good” category. Learning materials and assessment have “very good” category. This showed that the contents of lesson plans that prepared by economics teachers are comformity with curriculum 2013.Keyword : Lesson Plan, Implementation of Curriculum 2013