bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenesis of (smoking-related) non-communicable diseases—Evidence for a common underlying pathophysiological pattern
Authors: Kopp Wolfgang
Published: December 2022

Non-communicable diseases, like diabetes, cardiovascular diseases, cancer, stroke, chronic obstructive pulmonary disease, osteoporosis, arthritis, Alzheimer’s disease and other more are a leading cause of death in almost all countries. Lifestyle factors, especially poor diet and tobacco consumption, are considered to be the most important influencing factors in the development of these diseases. The Western diet has been shown to cause a significant distortion of normal physiology, characterized by dysregulation of the sympathetic nervous system, renin-angiotensin aldosterone system, and immune system, as well as disruption of physiological insulin and oxidant/antioxidant homeostasis, all of which play critical roles in the development of these diseases. This paper addresses the question of whether the development of smoking-related non-communicable diseases follows the same pathophysiological pattern. The evidence presented shows that exposure to cigarette smoke and/or nicotine causes the same complex dysregulation of physiology as described above, it further shows that the factors involved are strongly interrelated, and that all of these factors play a key role in the development of a broad spectrum of smoking-related diseases. Since not all smokers develop one or more of these diseases, it is proposed that this disruption of normal physiological balance represents a kind of pathogenetic “basic toolkit” for the potential development of a range of non-communicable diseases, and that the decision of whether and what disease will develop in an individual is determined by other, individual factors (“determinants”), such as the genome, epigenome, exposome, microbiome, and others. The common pathophysiological pattern underlying these diseases may provide an explanation for the often poorly understood links between non-communicable diseases and disease comorbidities. The proposed pathophysiological process offers new insights into the development of non-communicable diseases and may influence the direction of future research in both prevention and therapy.
Effectiveness of either short-duration ischemic pre-conditioning, single-set high-resistance exercise, or their combination in potentiating bench press exercise performance
Authors: Salagas Andreas , Tsoukos Athanasios , Terzis Gerasimos , Paschalis Vassilis , Katsikas Christos , Krzysztofik Michal , Wilk Michal , Zajac Adam , Bogdanis Gregory C.
Published: December 2022

This study compared the effects of short-duration ischemic preconditioning, a single-set high-resistance exercise and their combination on subsequent bench press performance. Twelve men (age: 25.8 ± 6.0 years, bench press 1-RM: 1.21 ± 0.17 kg kg−1 body mass) performed four 12 s sets as fast as possible, with 2 min of recovery between sets, against 60% 1-RM, after: a) 5 min ischemic preconditioning (IPC; at 100% of full arterial occlusion pressure), b) one set of three bench press repetitions at 90% 1-RM (PAPE), c) their combination (PAPE + IPC) or d) control (CTRL). Mean barbell velocity in ischemic preconditioning was higher than CTRL (by 6.6–9.0%, p < 0.05) from set 1 to set 3, and higher than PAPE in set 1 (by 4.4%, p < 0.05). Mean barbell velocity in PAPE was higher than CTRL from set 2 to set 4 (by 6.7–8.9%, p < 0.05), while mean barbell velocity in PAPE + IPC was higher than CTRL only in set 1 (+5.8 ± 10.0%). Peak barbell velocity in ischemic preconditioning and PAPE was higher than CTRL (by 7.8% and 8.5%, respectively; p < 0.05). Total number of repetitions was similarly increased in all experimental conditions compared with CTRL (by 7.0–7.9%, p < 0.05). Rating of perceived exertion was lower in ischemic preconditioning compared with CTRL (p < 0.001) and PAPE (p = 0.045), respectively. These results highlight the effectiveness of short-duration ischemic preconditioning in increasing bench press performance, and suggest that it may be readily used by strength and conditioning coaches during resistance training due to its brevity and lower perceived exertion.
Genetic basis of maize kernel protein content revealed by high-density bin mapping using recombinant inbred lines
Authors: Lu Xin , Zhou Zhiqiang , Wang Yunhe , Wang Ruiqi , Hao Zhuanfang , Li Mingshun , Zhang Degui , Yong Hongjun , Han Jienan , Wang Zhenhua , Weng Jianfeng , Zhou Yu , Li Xinhai
Published: December 2022

Maize with a high kernel protein content (PC) is desirable for human food and livestock fodder. However, improvements in its PC have been hampered by a lack of desirable molecular markers. To identify quantitative trait loci (QTL) and candidate genes for kernel PC, we employed a genotyping-by-sequencing strategy to construct a high-resolution linkage map with 6,433 bin markers for 275 recombinant inbred lines (RILs) derived from a high-PC female Ji846 and low-PC male Ye3189. The total genetic distance covered by the linkage map was 2180.93 cM, and the average distance between adjacent markers was 0.32 cM, with a physical distance of approximately 0.37 Mb. Using this linkage map, 11 QTLs affecting kernel PC were identified, including qPC7 and qPC2-2, which were identified in at least two environments. For the qPC2-2 locus, a marker named IndelPC2-2 was developed with closely linked polymorphisms in both parents, and when tested in 30 high and 30 low PC inbred lines, it showed significant differences (P = 1.9E-03). To identify the candidate genes for this locus, transcriptome sequencing data and PC best linear unbiased estimates (BLUE) for 348 inbred lines were combined, and the expression levels of the four genes were correlated with PC. Among the four genes, Zm00001d002625, which encodes an S-adenosyl-L-methionine-dependent methyltransferase superfamily protein, showed significantly different expression levels between two RIL parents in the endosperm and is speculated to be a potential candidate gene for qPC2-2. This study will contribute to further research on the mechanisms underlying the regulation of maize PC, while also providing a genetic basis for marker-assisted selection in the future.
Genome-wide association scan and transcriptome analysis reveal candidate genes for waterlogging tolerance in cultivated barley
Authors: Luan Haiye , Chen Changyu , Yang Ju , Qiao Hailong , Li Hongtao , Li Shufeng , Zheng Junyi , Shen Huiquan , Xu Xiao , Wang Jun
Published: December 2022

Waterlogging is the primary abiotic factor that destabilizes the yield and quality of barley (Hordeum vulgare L.). However, the genetic basis of waterlogging tolerance remains poorly understood. In this study, we conducted a genome-wide association study (GWAS) by involving 106,131 single-nucleotide polymorphisms (SNPs) with a waterlogging score (WLS) of 250 barley accessions in two years. Out of 72 SNPs that were found to be associated with WLS, 34 were detected in at least two environments. We further performed the transcriptome analysis in root samples from TX9425 (waterlogging tolerant) and Franklin (waterlogging sensitive), resulting in the identification of 5,693 and 8,462 differentially expressed genes (DEGs) in these genotypes, respectively. The identified DEGs included various transcription factor (TF) genes, primarily including AP2/ERF, bZIP and MYB. By combining GWAS and RNA-seq, we identified 27 candidate genes associated with waterlogging, of which three TFs (HvDnaJ, HvMADS and HvERF1) were detected in multiple treatments. Moreover, by overexpressing barley HvERF1 in Arabidopsis, the transgenic lines were detected with enhanced waterlogging tolerance. Altogether, our results provide new insights into the genetic mechanisms of waterlogging, which have implications in the molecular breeding of waterlogging-tolerant barley varieties.
Effects of chicken manure substitution for mineral nitrogen fertilizer on crop yield and soil fertility in a reduced nitrogen input regime of North-Central China
Authors: Ning Linyirui , Xu Xinpeng , Zhang Yitao , Zhao Shicheng , Qiu Shaojun , Ding Wencheng , Zou Guoyuan , He Ping
Published: December 2022

Organic manure has been proposed to substitute part of the chemical fertilizers. However, past research was usually conducted in regimes with excessive nitrogen (N) fertilization, which was not conducive to the current national goal of green and sustainable development. Therefore, exploring the potential of organic fertilizer substitution for mineral N fertilizer under regimes with reduced N inputs is important to further utilize organic fertilizer resources and establish sustainable nutrient management recommendations in the winter wheat (Triticum aestivum L.) – summer maize (Zea mays L.) rotation system in North-central China. In this study, a 4-year field experiment was conducted to investigate the effects of different chicken manure substitution ratios on crop yield, N recovery efficiency (REN), soil N and soil organic matter contents, to clarify the optimal organic substitution ratio of N fertilizer under reduced N application (from 540 kg N ha−1 year−1 to 400 kg N ha−1 year−1). Six substitution ratios were assessed: 0%, 20%, 40%, 60%, 80% and 100% under 200 kg N ha−1 per crop season, respectively, plus a control with no N application from chemical fertilizer or chicken manure. Results showed that the highest yield was achieved under the 20% substitution ratio treatment, with 1.1% and 2.3% higher yield than chemical N alone in wheat season and maize seasons, respectively. At the chicken manure substitution ratios of 20% in wheat season and 20%-40% in maize season, the highest REN reached to 31.2% and 26.1%, respectively. Chicken manure application reduced soil residual inorganic N with increasing substitution ratio. All organic substitution treatments increased soil organic matter and total N content. Implementing 20% organic substitution in wheat season and 20%-40% in maize season under the reduced N application regime in the North-central China is therefore recommended in order to achieve high crop yields and REN, improve soil fertility and enhance livestock manure resource utilization.
Machine learning and analysis of genomic diversity of “Candidatus Liberibacter asiaticus” strains from 20 citrus production states in Mexico
Authors: Huang Jiaquan , Alanís-Martínez Iobana , Kumagai Lucita , Dai Zehan , Zheng Zheng , Perez de Leon Adalberto A. , Chen Jianchi , Deng Xiaoling
Published: December 2022

Background

Huanglongbing (HLB, yellow shoot disease) is a highly destructive citrus disease associated with a nonculturable bacterium, “Candidatus Liberibacter asiaticus” (CLas), which is transmitted by Asian citrus psyllid (ACP, Diaphorina citri). In Mexico, HLB was first reported in Tizimin, Yucatán, in 2009 and is now endemic in 351 municipalities of 25 states. Understanding the population diversity of CLas is critical for HLB management. Current CLas diversity research is exclusively based on analysis of the bacterial genome, which composed two regions, chromosome (> 1,000 genes) and prophage (about 40 genes).

Methods and results

In this study, 40 CLas-infected ACP samples from 20 states in Mexico were collected. CLas was detected and confirmed by PCR assays. A prophage gene(terL)-based typing system (TTS) divided the Mexican CLas strains into two groups: Term-G including four strains from Yucatán and Chiapas, as well as strain psy62 from Florida, USA, and Term-A included all other 36 Mexican strains, as well as strain AHCA1 from California, USA. CLas diversity was further evaluated to include all chromosomal and prophage genes assisted by using machine learning (ML) tools to resolve multidimensional data handling issues. A Term-G strain (YTMX) and a Term-A strain (BCSMX) were sequenced and analyzed. The two Mexican genome sequences along with the CLas genome sequences available in GenBank were studied. An unsupervised ML was implemented through principal component analysis (PCA) on average nucleotide identities (ANIs) of CLas whole genome sequences; And a supervised ML was implemented through sparse partial least squares discriminant analysis (sPLS-DA) on single nucleotide polymorphisms (SNPs) of coding genes of CLas guided by the TTS. Two CLas Geno-groups, Geno-group 1 that extended Term-A and Geno-group 2 that extended Term-G, were established.

Conclusions

This study concluded that: 1) there were at least two different introductions of CLas into Mexico; 2) CLas strains between Mexico and USA are closely related; and 3) The two Geno-groups provide the basis for future CLas subspecies research.
Peptides/receptors signaling during plant fertilization
Authors: Yu Tian-Ying , Xu Chun-Xia , Li Wen-Jia , Wang Bo
Published: December 2022

Double fertilization is a unique and particularly complicated process for the generation alternation of angiosperms. Sperm cells of angiosperms lose the motility compared with that of gymnosperms. The sperm cells are passively carried and transported by the pollen tube for a long journey before targeting the ovule. Two sperm cells are released at the cleft between the egg and the central cell and fused with two female gametes to produce a zygote and endosperm, respectively, to accomplish the so-called double fertilization process. In this process, extensive communication and interaction occur between the male (pollen or pollen tube) and the female (ovule). It is suggested that small peptides and receptor kinases play critical roles in orchestrating this cell-cell communication. Here, we illuminate the understanding of phases in the process, such as pollen-stigma recognition, the hydration and germination of pollen grains, the growth, guidance, and rupture of tubes, the release of sperm cells, and the fusion of gametes, by reviewing increasing data recently. The roles of peptides and receptor kinases in signaling mechanisms underlying cell-cell communication were focused on, and directions of future studies were perspected in this review.
Histone variants and modifications during abiotic stress response
Authors: Nunez-Vazquez Rocío , Desvoyes Bénédicte , Gutierrez Crisanto
Published: December 2022

Plants have developed multiple mechanisms as an adaptive response to abiotic stresses, such as salinity, drought, heat, cold, and oxidative stress. Understanding these regulatory networks is critical for coping with the negative impact of abiotic stress on crop productivity worldwide and, eventually, for the rational design of strategies to improve plant performance. Plant alterations upon stress are driven by changes in transcriptional regulation, which rely on locus-specific changes in chromatin accessibility. This process encompasses post-translational modifications of histone proteins that alter the DNA-histones binding, the exchange of canonical histones by variants that modify chromatin conformation, and DNA methylation, which has an implication in the silencing and activation of hypervariable genes. Here, we review the current understanding of the role of the major epigenetic modifications during the abiotic stress response and discuss the intricate relationship among them.
Is it possible to defeat right-wing populist authorities by winning elections? The erosion of democracy and the system of the triple-masters class in Poland
Authors: Żuk Piotr , Pacześniak Anna
Published: December 2022

The article poses an extremely important question of whether it is possible to remove authoritarian authorities using the methods of parliamentary democracy in a situation where the government has weakened or dismantled democratic mechanisms and institutions. The article treats the rule of right-wing populists as a comprehensive ruling system of the triple-masters class (identified with the apparatus of the ruling party), who fully controls the political, cultural, and economic spheres. The nationalist cultural and ideological superstructure legitimizes the rule of right-wing populists, but it is only a means to build the economic hegemony of the triple-masters class and strengthen their political power. Based on the material gathered during focus group interviews with opposition party activists, the article outlines the main problems faced by the opposition in the state of the triple-masters class.
Predicting school readiness program implementation in community-based childcare centers
Authors: Hunter Leah J. , Bayly Benjamin L. , Bierman Karen L. , Welsh Janet A. , Gest Julia M.
Published: December 2022

Introduction

Targeted curricular interventions can increase preschool program quality and boost children’s academic and social–emotional readiness skills, but variable funding and weak organizational infrastructure in many community-based childcare centers may reduce the effective implementation of these programs.

Method

This study examined individual teacher and workplace predictors of the REDI program implementation, a targeted school readiness program that was adapted to support delivery in childcare centers. REDI was delivered by 63 teachers in 37 community-based childcare centers with center directors serving as local implementation coaches.

Results

Results showed that individual teacher factors (e.g., teaching skills and receptivity to intervention consultation) predicted the quality with which REDI activities and teaching strategies were delivered, and workplace factors were important predictors across multiple implementation indicators.

Discussion

Practice and policy implications for improving intervention implementation and corresponding program quality in childcare centers are highlighted.
Teacher autonomy support and externalizing problems: Variations based on growth mindset toward personality and ethnicity
Authors: Ma Yongfeng , Ma Chunhua , Lan Xiaoyu
Published: December 2022

Introduction

Given the prevalence of externalizing problems during adolescence, the present study investigated the main and interactive relationships between environmental-level (teacher autonomy support) and person-level (growth mindset toward personality) factors related to externalizing problems. This study further estimated ethnic variations of these relationships among the majority Han and one ethnic minority group (Hui) in China.

Methods

To achieve the research objectives, the study involved 704 Han (Mage = 12.57; 53.7% female) and 642 Hui adolescents (Mage = 12.45; 49.4% female) who completed a suite of research questionnaires.

Results

The results of the hierarchical linear regression analysis, after controlling for sociodemographic characteristics and comorbid internalizing problems, showed that teacher autonomy support was directly and negatively related to externalizing problems. This negative relationship was also moderated by growth mindset toward personality and ethnicity. More specifically, a high growth mindset buffered the undesirable effect of low teacher autonomy support on externalizing problems for Hui adolescents but not Han adolescents.

Discussion

The finding from the current research suggests that teacher autonomy support plays a universally beneficial role in youth mental health across two selected ethnic groups. At the same time, identifying the protective role of growth mindset has important practical implications for the design of personalized school-based activities that aim to facilitate adaptive youth behaviors.
A behaviorally informed financial education program for the financially vulnerable: Design and effectiveness
Authors: de Bruijn Ernst-Jan , Antonides Gerrit , Madern Tamara
Published: December 2022

Financially vulnerable consumers are often associated with suboptimal financial behaviors. Evaluated financial education programs so far show difficulties to effectively reach this target population. In our attempt to solve this problem, we built a behaviorally informed financial education program incorporating insights from both motivational and behavioral change theories. In a quasi-experimental field study among Dutch financially vulnerable people, we compared this program with both a control group and a traditional program group. In comparison with the control group, we found robust positive effects of the behaviorally informed program on financial skills and knowledge and self-reported financial behavior, but not on other outcomes. Additionally, we did not find evidence that the behaviorally informed program performed better than the traditional program. Finally, we discuss the findings and limitations of this study in light of the financial education literature and provide implications for policymaking and directions for future research.
Top management team boundary-spanning leadership: Measurement development and its impact on innovative behavior
Authors: Liu Xuemei , Yu Yuan , Zhao Xiuwen , Zhang Ningjun
Published: December 2022

With the advancement of digital economy, organizations around the world need to stretch the boundaries of their strategy, business, and knowledge to gain a competitive advantage and achieve sustainable growth. Although boundary-spanning leadership, with a set of practical tools developed by the Center for Creative Leadership (CCL), has been explored over the past 10 years, the comprehensive understanding of top management team boundary-spanning leadership has still reached no consensus. This research focuses on the concept of top management team boundary-spanning leadership (TMTBSL) and its effect on employees’ innovative behavior. Study 1 comprises the concept of TMTBSL and the measurement of its development. The classical grounded theory was used to analyze biographical texts and in-depth interview data from local Chinese organizations. We developed a 5-dimension scale with14 items for TMTBSL. In Study 2, we empirically examined the impact of TMTBSL on employees’ innovative behavior. The results demonstrate that TMTBSL can promote employee innovative behavior through perceived motivational climate. The theoretical and practical implications are also outlined.
Mental but no bio-physiological long-term habituation to repeated social stress: A study on soldiers and the influence of mission abroad
Authors: Maier Tanja , Rappel Manuela , Rhee Dae-Sup , Brill Sebastian , Maderner Julia , Pijahn Friederike , Gündel Harald , Radermacher Peter , Friemert Benedikt , Becker Horst-Peter , Waller Christiane
Published: December 2022

Soldiers regularly participate in missions abroad and subjectively adapt to this situation. However, they have an increased lifetime cardiovascular risk compared to other occupational groups. To test the hypothesis that foreign deployment results in different stress habituation patterns, we investigated long-term psychological and bio-physiological stress responses to a repeated social stress task in healthy soldiers with and without foreign deployment. Ninety-one female and male soldiers from the BEST study (German armed forces deployment and stress) participated three times in the Trier Social Stress Test for groups (TSST-G) prior to, 6–8 weeks after and 1 year after the mission abroad and were compared to a control group without foreign deployment during the study period. They completed the State-Trait-Anxiety Inventory scale (STAI), the Primary Appraisal Secondary Appraisal questionnaire (PASA) and the Multidimensional Mood State Questionnaire (MDBF). Salivary cortisol and α-amylase, blood pressure, heart rate and heart rate variability were determined. Soldiers showed mental habituation over the three times with a significant decrease after the TSST-G in anxiousness (STAI) and cognitive stress appraisal (PASA), they were calmer and reported better mood (MDBF). Prior to the social stress part, the mood (MDBF) declined significantly. None of the biological and physiological markers showed any adaptation to the TSST-G. Mission abroad did not significantly influence any measured psychobiological marker when compared to soldiers without foreign deployment. Foreign deployment does not result in alterations in psychobiological social stress response patterns over 1 year after mission abroad which indicates that adaptation to acute social stress is highly maintained in healthy soldiers. The discrepancy between subjective perception and objective stress response has numerous clinical implications and should receive more attention.
Recognition of social health: A conceptual framework in the context of dementia research
Authors: Vernooij-Dassen Myrra , Verspoor Eline , Samtani Suraj , Sachdev Perminder S. , Ikram M. Arfan , Vernooij Meike W. , Hubers Claudia , Chattat Rabih , Lenart-Bugla Marta , Rymaszewska Joanna , Szczesniak Dorota , Brodaty Henry , Welmer Anna-Karin , Maddock Jane , van der Velpen Isabelle F. , Wiegelmann Henrik , Marseglia Anna , Richards Marcus , Melis Rene , de Vugt Marjolein , Moniz-Cook Esme , Jeon Yun-Hee , Perry Marieke , Wolf-Ostermann Karin
Published: December 2022

Objective

The recognition of dementia as a multifactorial disorder encourages the exploration of new pathways to understand its origins. Social health might play a role in cognitive decline and dementia, but conceptual clarity is lacking and this hinders investigation of associations and mechanisms. The objective is to develop a conceptual framework for social health to advance conceptual clarity in future studies.

Process

We use the following steps: underpinning for concept advancement, concept advancement by the development of a conceptual model, and exploration of its potential feasibility. An iterative consensus-based process was used within the international multidisciplinary SHARED project.

Conceptual framework

Underpinning of the concept drew from a synthesis of theoretical, conceptual and epidemiological work, and resulted in a definition of social health as wellbeing that relies on capacities both of the individual and the social environment. Consequently, domains in the conceptual framework are on both the individual (e.g., social participation) and the social environmental levels (e.g., social network). We hypothesize that social health acts as a driver for use of cognitive reserve which can then slow cognitive impairment or maintain cognitive functioning. The feasibility of the conceptual framework is demonstrated in its practical use in identifying and structuring of social health markers within the SHARED project.

Discussion

The conceptual framework provides guidance for future research and facilitates identification of modifiable risk and protective factors, which may in turn shape new avenues for preventive interventions. We highlight the paradigm of social health in dementia as a priority for dementia research.
Staff’s experiences of implementing patient-initiated brief admission for adolescents from the perspective of epistemic (in)justice
Authors: Moberg Jennie , Schön Ulla-Karin
Published: December 2022

Background

The implementation of Patient-Initiated Brief Admission (PIBA) in child and adolescent psychiatry (CAP) in Sweden is ongoing. This intervention enables adolescents between the ages of 13–17 and with complex mental health problems to initiate a short care period for relief and support rather than the care apparatus being controlling in this process. Offering it is likely to promote epistemic agency, an exchange of knowledge and recovery from mental health problems.

Aim

The aim of this study was to explore staff’s perspectives of PIBA for adolescents with complex mental health problems, and what facilitates or hinders its implementation.

Methods

Twenty seven employees, 21 women and six men, with various professions in CAP were interviewed and the material was analyzed thematically.

Results

Two overall themes emerged: “Staff’s Experiences of PIBA” and “Managing Clinical PIBA Work.” The results were discussed in relation to the theoretical frameworks of epistemic injustice and Normalization Process Theory (NPT). The main findings indicate that PIBA was generally viewed in a positive way, but that obstacles arose when it was actually put into practice. Findings also point at an overall lack of agency among staff when implementing this new way of working, at the same time as the need to adapt PIBA from an adult psychiatric intervention to one for adolescents in CAP is addressed.

Conclusion

This article offers insights into the views of psychiatric staff regarding the implementation of PIBA. If staff wish to support epistemic agency and recovery among adolescents, their agency may be an important aspect in the continued implementation. Furthermore, in order for PIBA to become normalized in a sustainable way, we suggest that the continued implementation should be characterized by a youth-friendly framework.
Transition patterns of metabolism-weight phenotypes over time: A longitudinal study using the multistate Markov model in China
Authors: Zhang Hongya , Tang Xiao , Hu Dongmei , Li Guorong , Song Guirong
Published: December 2022

Background

A change in weight or metabolic status is a dynamic process, yet most studies have focused on metabolically healthy obesity (MHO) and the transition between MHO and metabolically unhealthy obesity (MUO); therefore, they have not fully revealed the nature of all possible transitions among metabolism-weight phenotypes over the years.

Methods

This was a longitudinal study based on a retrospective health check-up cohort. A total of 9,742 apparently healthy individuals aged 20–60 years at study entry were included and underwent at least two health check-ups. Six metabolism-weight phenotypes were cross-defined by body mass index (BMI) categories and metabolic status as follows: metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), MHO, metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW), and MUO. A multistate Markov model was used to analyse all possible transitions among these phenotypes and assess the effects of demographic and blood indicators on the transitions.

Results

The transition intensity from MUNW to MHNW was the highest (0.64), followed by the transition from MHO to MUO (0.56). The greatest sojourn time appeared in the MHNW state (3.84 years), followed by the MUO state (2.34 years), and the shortest sojourn time appeared in the MHO state (1.16 years). Transition intensities for metabolic improvement gradually decreased with BMI level as follows: 0.64 for MUNW to MHNW, 0.44 for MUOW to MHNW, and 0.27 for MUO to MHO; however, transition intensities for metabolic deterioration, including MHNW to MUNW, MHOW to MUOW, and MHO to MUO, were 0.15, 0.38, and 0.56, respectively. In the middle-aged male group, elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and uric acid (UA) increased the risk of deterioration in weight and metabolic status and decreased the possibility of improvement.

Conclusion

Maintaining a normal and stable BMI is important for metabolic health. More attention should be given to males and elderly people to prevent their progression to an unhealthy metabolic and/or weight status. MHO is the most unstable phenotype and is prone to convert to the MUO state, and individuals with abnormal ALT, AST and UA are at an increased risk of transitioning to an unhealthy weight and/or metabolic status; therefore, we should be alert to abnormal indicators and MHO. Intervention measures should be taken early to maintain healthy weight and metabolic status.
Access to quality health resources and environmental toxins affect the relationship between brain structure and BMI in a sample of pre and early adolescents
Authors: Adise Shana , Marshall Andrew T. , Kan Eric , Sowell Elizabeth R.
Published: December 2022

Background

Environmental resources are related to childhood obesity risk and altered brain development, but whether these relationships are stable or if they have sustained impact is unknown. Here, we utilized a multidimensional index of childhood neighborhood conditions to compare the influence of various social and environmental disparities (SED) on body mass index (BMI)-brain relationships over a 2-year period in early adolescence.

Methods

Data were gathered the Adolescent Brain Cognitive Development Study® (n = 2,970, 49.8% female, 69.1% White, no siblings). Structure magnetic resonance imaging (sMRI), anthropometrics, and demographic information were collected at baseline (9/10-years-old) and the 2-year-follow-up (11/12-years-old). Region of interest (ROIs; 68 cortical, 18 subcortical) estimates of cortical thickness and subcortical volume were extracted from sMRI T1w images using the Desikan atlas. Residential addresses at baseline were used to obtain geocoded estimates of SEDs from 3 domains of childhood opportunity index (COI): healthy environment (COIHE), social/economic (COISE), and education (COIED). Nested, random-effects mixed models were conducted to evaluate relationships of BMI with (1) ROI * COI[domain] and (2) ROI * COI[domain]* Time. Models controlled for sex, race, ethnicity, puberty, and the other two COI domains of non-interest, allowing us to estimate the unique variance explained by each domain and its interaction with ROI and time.

Results

Youth living in areas with lower COISE and COIED scores were heavier at the 2-year follow-up than baseline and exhibited greater thinning in the bilateral occipital cortex between visits. Lower COISE scores corresponded with larger volume of the bilateral caudate and greater BMI at the 2-year follow-up. COIHE scores showed the greatest associations (n = 20 ROIs) with brain-BMI relationships: youth living in areas with lower COIHE had thinner cortices in prefrontal regions and larger volumes of the left pallidum and Ventral DC. Time did not moderate the COIHE x ROI interaction for any brain region during the examined 2-year period. Findings were independent of family income (i.e., income-to-needs).

Conclusion

Collectively our findings demonstrate that neighborhood SEDs for health-promoting resources play a particularly important role in moderating relationships between brain and BMI in early adolescence regardless of family-level financial resources.
Decentralized clinical trials (DCTs): A few ethical considerations
Authors: Petrini Carlo , Mannelli Chiara , Riva Luciana , Gainotti Sabina , Gussoni Gualberto
Published: December 2022

Decentralized clinical trials (DCTs) are studies in which the need for patients to physically access hospital-based trial sites is reduced or eliminated. The CoViD-19 pandemic has caused a significant increase in DCT: a survey shows that 76% of pharmaceutical companies, device manufacturers, and Contract Research Organizations adopted decentralized techniques during the early phase of the pandemic. The implementation of DCTs relies on the use of digital tools such as e-consent, apps, wearable devices, Electronic Patient-Reported Outcomes (ePRO), telemedicine, as well as on moving trial activities to the patient's home (e.g., drug delivery) or to local healthcare settings (i.e., community-based diagnosis and care facilities). DCTs adapt to patients' routines, allow patients to participate regardless of where they live by removing logistical barriers, offer better access to the study and the investigational product, and permit the inclusion of more diverse and more representative populations. The feasibility and quality of DCTs depends on several requirements including dedicated infrastructures and staff, an adequate regulatory framework, and partnerships between research sites, patients and sponsors. The evaluation of Ethics Committees (ECs) is crucial to the process of innovating and digitalizing clinical trials: adequate assessment tools and a suitable regulatory framework are needed for evaluation by ECs. DCTs also raise issues, many of which are of considerable ethical significance. These include the implications for the relationship between patients and healthcare staff, for the social dimension of the patient, for data integrity (at the source, during transmission, in the analysis phase), for personal data protection, and for the possible risks to health and safety. Despite their considerable growth, DCTs have only received little attention from bioethicists. This paper offers a review on some ethical implications and requirements of DCTs in order to encourage further ethical reflection on this rapidly emerging field.
Assessment of facility-level antiretroviral treatment patient status utilizing a national-level laboratory cohort: Toward an understanding of system-level tracking and clinic switching in South Africa
Authors: Murphy Joshua P. , Shumba Khumbo , Jamieson Lise , Nattey Cornelius , Pascoe Sophie , Fox Matthew P. , Miot Jacqui , Maskew Mhairi
Published: December 2022

Background

Most estimates of HIV retention are derived at the clinic level through antiretroviral (ART) patient management systems, which capture ART clinic visit data, yet these cannot account for silent transfers across HIV treatment sites. Patient laboratory monitoring visits may also be observed in routinely collected laboratory data, which include ART monitoring tests such as CD4 count and HIV viral load, key to our work here.

Methods

In this analysis, we utilized the NHLS National HIV Cohort (a system-wide viewpoint) to investigate the accuracy of facility-level estimates of retention in care for adult patients accessing care (defined using clinic visit data on patients under ART recorded in an electronic patient management system) at Themba Lethu Clinic (TLC). Furthermore, we describe patterns of facility switching among all patients and those patients classified as lost to follow-up (LTFU) at the facility level.

Results

Of the 43,538 unique patients in the TLC dataset, we included 20,093 of 25,514 possible patient records (78.8%) in our analysis that were linked with the NHLS National Cohort, and we restricted the analytic sample to patients initiating ART between 1 January 2007 and 31 December 2017. Most (60%) patients were female, and the median age (IQR) at ART initiation was 37 (31–45) years. We found the laboratory records augmented retention estimates by a median of 860 additional active records (about 8% of all median active records across all years) from the facility viewpoint; this augmentation was more noticeable from the system-wide viewpoint, which added evidence of activity of about one-third of total active records in 2017. In 2017, we found 7.0% misclassification at the facility-level viewpoint, a gap which is potentially solvable through data integration/triangulation. We observed 1,134/20,093 (5.6%) silent transfers; these were noticeably more female and younger than the entire dataset. We also report the most common locations for clinic switching at a provincial level.

Discussion

Integration of multiple data sources has the potential to reduce the misclassification of patients as being lost to care and help understand situations where clinic switching is common. This may help in prioritizing interventions that would assist patients moving between clinics and hopefully contribute to services that normalize formal transfers and fewer silent transfers.
Robust and accurate pulmonary nodule detection with self-supervised feature learning on domain adaptation
Authors: Liu Jingya , Cao Liangliang , Akin Oguz , Tian Yingli
Published: December 2022

Medical imaging data annotation is expensive and time-consuming. Supervised deep learning approaches may encounter overfitting if trained with limited medical data, and further affect the robustness of computer-aided diagnosis (CAD) on CT scans collected by various scanner vendors. Additionally, the high false-positive rate in automatic lung nodule detection methods prevents their applications in daily clinical routine diagnosis. To tackle these issues, we first introduce a novel self-learning schema to train a pre-trained model by learning rich feature representatives from large-scale unlabeled data without extra annotation, which guarantees a consistent detection performance over novel datasets. Then, a 3D feature pyramid network (3DFPN) is proposed for high-sensitivity nodule detection by extracting multi-scale features, where the weights of the backbone network are initialized by the pre-trained model and then fine-tuned in a supervised manner. Further, a High Sensitivity and Specificity (HS2) network is proposed to reduce false positives by tracking the appearance changes among continuous CT slices on Location History Images (LHI) for the detected nodule candidates. The proposed method’s performance and robustness are evaluated on several publicly available datasets, including LUNA16, SPIE-AAPM, LungTIME, and HMS. Our proposed detector achieves the state-of-the-art result of 90.6% sensitivity at 1/8 false positive per scan on the LUNA16 dataset. The proposed framework’s generalizability has been evaluated on three additional datasets (i.e., SPIE-AAPM, LungTIME, and HMS) captured by different types of CT scanners.
Detection of Mycoplasma bovirhinis and bovine coronavirus in an outbreak of bovine respiratory disease in nursing beef calves
Authors: McDaneld Tara G. , Workman Aspen M. , Chitko-McKown Carol G. , Kuehn Larry A. , Dickey Aaron , Bennett Gary L.
Published: December 2022

Introduction

Respiratory disease incidence is intimately associated with an animal’s commensal bacteria populations (microbiome), as microbes that are involved with morbidity and mortality are commonly found in animals with no sign of disease. In addition, viral pathogens affect the immune system and appear to play an integral role in the overall incidence of bovine respiratory disease (BRD); so, an understanding of the interaction of the bacterial and viral pathogens in the upper respiratory tract (URT) may help us to understand the impact of these pathogens on development of BRD. For this research, the overall goal was to characterize bacterial and viral populations in the URT of nursing beef calves at initial vaccination and at the time of a BRD outbreak.

Methods

Nasal swabs from the URT were collected at initial vaccination (average 45 days of age) and again at the time of the BRD outbreak (average 126 days of age). DNA and RNA were extracted from nasal swabs to evaluate bacterial and viral populations in the URT. Whole blood was also collected at the time of the BRD outbreak for determination of complete blood counts. To evaluate the microbiome, hypervariable regions 1 through 3 along the 16S ribosomal RNA (rRNA) gene were amplified by PCR and sequenced using next-generation sequencing (Illumina MiSeq) for identification of the bacterial taxa present. To evaluate the viral pathogens, multiplex reverse transcription real-time polymerase chain reaction and next-generation sequencing (Illumina NextSeq) was completed.

Results

Overall, evaluation of these samples revealed that at the time of the BRD outbreak, all calves were nasally shedding bovine coronavirus and a large percentage had a coinfection with Mycoplasma sp., with Mycoplasma bovirhinis being the predominant species. Neither bovine coronavirus nor Mycoplasma sp. were present at high abundance at the earlier timepoint of initial vaccination. When comparing bacterial population diversity between the two sampling timepoints, alpha diversity was significantly greater at initial vaccination compared to the BRD outbreak (P-value <0.001). Values of leukocytes at the time of the BRD outbreak were also identified to be significantly different between calves with normal or elevated rectal temperatures (P-value <0.05).

Discussion

Analysis of the respiratory microflora in the URT during initial vaccination and a BRD outbreak will provide insight into the distribution of bacterial and viral populations in nursing beef calves.
Advancements in autonomous mobility of planetary wheeled mobile robots: A review
Authors: Zarei Mahboubeh , Chhabra Robin
Published: December 2022

Mobility analysis is crucial to fast, safe, and autonomous operation of planetary Wheeled Mobile Robots (WMRs). This paper reviews implemented odometry techniques on currently designed planetary WMRs and surveys methods for improving their mobility and traversability. The methods are categorized based on the employed approaches ranging from signal-based and model-based estimation to terramechanics-based, machine learning, and global sensing techniques. They aim to detect vehicle motion parameters (kinematic states and forces/torques), terrain hazards (slip and sinkage) and terrain parameters (soil cohesion and friction). The limitations of these methods and recommendations for future missions are stated.
Key metrics to measure the performance and impact of reusable packaging in circular supply chains
Authors: Betts Kellen , Gutierrez-Franco Edgar , Ponce-Cueto Eva
Published: December 2022

Circular supply chains comprise the industrial production and supply chain systems used by companies to eliminate waste and recover value in products and materials. There are a variety of circular strategies including recycling in waste management, returns and repair in consumer-facing industries, and reusable packaging in supply chains. Successful implementation and management of these circular strategies requires the ability to measure and report on progress across different functions and processes. In this paper, we propose a new set of metrics to measure the performance of reusing items in a circular supply chain. We review the literature on metrics in circular supply chain management and reusable packaging in supply chains. We then classify the proposed metrics based on whether they measure the circularity of a circular supply chain initiative or impact of implementing the initiative. They also are segmented based on the level of detail they incorporate from the product level to the system level. We then demonstrate the use of the proposed metrics through a case study with an omnichannel retail company. We find that product-level metrics facilitate the comparison of different types of reusable and single-use packages with the potential to reduce lifecycle greenhouse gas emissions. We also find that measuring system-level Total Logistics Costs helps identify potential challenges with the feasibility of a reusable packaging system including the implications of not recovering packages and amortizing initial costs across multiple use cycles. Our aim in this paper is to address the gap in circularity and impact metrics focused on reuse strategies in supply chains. This new set of metrics provides companies with a tool to measure and report on progress toward a circular economy. It also suggests future avenues for research to assess the economic, environmental, and social dimensions of sustainability.
Assessing the sustainability impacts of food sharing initiatives: User testing The Toolshed SIA
Authors: Mackenzie Stephen George , Davies Anna R.
Published: December 2022

The food system is unsustainable and requires reconfiguration, however more data is required to assess the impacts of action which might contribute to a more sustainable food future. Responding to this, extensive research with food sharing initiatives—activities which have been flagged for their potential sustainability credentials—led to the co-design of an online sustainability impact assessment (SIA) tool to support food sharing initiatives to asses and evidence their sustainability impacts. This paper reports on the initial user testing of the resulting online tool: The Toolshed which forms the indicator based SIA element of the SHARE IT platform. Feedback gathered from the initiatives testing the tool are analyzed and summaries of their reported impacts detailed. This analysis confirms the need for the tool, the relevance of the indicators included and the value of SIA reports for internal reflection and external communication. Nonetheless, challenges remain in relation to resourcing the practice of SIA reporting. We conclude with a plan for expanding engagement with The Toolshed and the wider SHARE IT platform.