bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between education level, age , and knowledge of pregnant women with antenatal care status
Authors: Fegita Primadella , Hikmah Miftahul , Malik Rifkind
Published: June 2022

Background: Maternal mortality in Indonesia was still quite high. To reduce the mortality rate of the government made a health care program for pregnant women, namely antenatal care services (ANC). Education, knowledge and age of mothers were one of the determinants of maternal death. The purpose of this study was to determine the relationship of formal education levels, maternal age and level of knowledge with health to ANC. Method: Observational analytic research type with a cross-sectional approach, using primary data, namely quizerer and secondary book data KIA. Data were analyzed univariate and bivariate using Spearman Rho test. Results: Univariate analysis, pregnant women with a higher education level of 7 people (21.9%), while 8 people (25.0%), 17 people (53.1%); Pregnant women with the same high and low knowledge level, 50%; Mother's age <20 years and> 35 years 10 people (31.3%) and mothers age 20-35 years 22 people (68.8%); Pregnant women with a complete ANC status of 15 people (46.9%), and 17 people were incomplete (53.1%); Spearman Rho Bivariat Test, the relationship of the level of formal education and the level of maternal knowledge with ANC P <0.05, while maternal age relations with ANC P> 0.05. Conclusion: The majority of pregnant women with low educated with the age range of 20-35 years. There was a significant and direct relationship between the level of education and the level of knowledge with ANC status.
VALIDATION OF LC-MS/MS METHOD FOR DETERMINATION OF CYPROHEPTADINE IN DIETARY SUPPLEMENTS
Authors: Nguyen Van Sy , Le Hong Dung
Published: June 2022

Aims: A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was validated for determination of prohibited cyproheptadine hydrochloride (CP) in dietary supplements.

Methods: CP was extracted by sonication in methanol for 30 min. The chromatography separation of CP took place on C18 column (100 mm x 2.1 mm, 1.8 µm) with gradient mobile phase of both of acetonitrile and water containing 0.1% formic acid. Multiple reaction monitoring (MRM) in the positive mode was used to quantify and confirm CP at m/z 288.2/191.1  and 288.1/96.0, respectively.

Results: The method was validated according to the AOAC requirements. The linearity ranges were found from 0.1 to 50 ng. mL-1 of CP (R2 = 1). The limit of detection and limit of quantification were 1.5 ng/g or ng/mL and 5 ng/g or ng/mL, respectively. The accuracy was within the range from 92 to 99%, with the relative standard deviation (RSD%) of 2.0-5.9%.

Conclusion: The validated parameters have met the requirement of Association of Official Agricultural Chemists (AOAC). This reliable method would be useful for the monitoring of cyproheptadine in dietary supplements.
PHÁT TRIỂN VI KHUẨN LẬU KHÁNG KHÁNG SINH BẰNG KỸ THUẬT LAI PHÂN TỬ TẠI BỆNH VIỆN DA LIỄU TRUNG ƯƠNG NĂM 2020
Authors: Hoa Nguyễn Thị Phương , Hải Lê Hạ Long , Hưng Lê Văn
Published: June 2022

Sự kháng kháng sinh của vi khuẩn lậu diễn biến rất phức tạp gây rất nhiều khó khăn cho chẩn đoán và điều trị. Vì vậy, những nghiên cứu về phát triển kỹ thuật mới và tình hình kháng kháng sinh của vi khuẩn lậu là rất cần thiết nhằm giúp bác sỹ lâm sàng điều trị có hiệu quả và giám sát được các chủng đa đề kháng. Nghiên cứu xác định tỷ lệ nhiễm vi khuẩn lậu bằng kỹ thuật lai phân tử và tình trạng kháng kháng sinh của vi khuẩn lậu phân lập được tại Bệnh viện Da liễu Trung ương năm 2020. Phương pháp: Vi khuẩn lậu được phân lập từ bệnh phẩm là mủ hoặc dịch viêm của 780 bệnh nhân mắc hội chứng tiết dịch niệu đạo, âm đạo được xác định bằng kỹ thuật: Lai phân tử, nhuộm soi, nuôi cấy, định danh và làm kháng sinh đồ. Kết quả: 1. Tỷ lệ nhiễm vi khuẩn lậu ở bệnh nhân mắc hội chứng tiết dịch niệu đạo, âm đạo là 16,67%; 2. Vi khuẩn lậu kháng: ciprofloxacin (100%), nalidixic acid (77,45%), penicillin (50,98%), tetracyclin (77,50%); azithromycin (17,65%). Nhậy cảm: Spectinomycin (100%), cefotaxim (99,02%), cefixime (97,06%), ceftriaxone (99,02%). Kết luận: Ceftriaxone, spectinomycin, cefixime và cefotaxim là những kháng sinh nên được khuyến cáo để điều trị vi khuẩn lậu. Các kháng sinh sau không nên khuyến cáo điều trị vi khuẩn lậu là: Ciprofloxacin, tetracyclin, azithromycin và penicillin.
HIỆU QUẢ ĐIỀU TRỊ BẠCH BIẾN THỂ KHU TRÚ BẰNG BÔI TACROLIMUS KẾT HỢP CHIẾU ĐÈN EXCIMER
Authors: Nguyễn Thái Minh Hảo  , Đỗ Thị Thu Hiền
Published: June 2022

Mở đầu: Ánh sáng excimer (308nm) là một trong những lựa chọn ưu tiên trong điều trị bạch biến thể khu trú những năm gần đây. Nguồn dữ liệu về phương pháp kết hợp chiếu đèn excimer và tacrolimus bôi trong điều trị bạch biến thể khu trú còn hạn chế.

Mục tiêu: Nghiên cứu nhằm đánh giá kết quả điều trị bạch biến thể khu trú bằng bôi tacrolimus kết hợp chiếu đèn excimer.

Phương pháp: Thử nghiệm lâm sàng có so sánh trước – sau điều trị, thực hiện trên 30 bệnh nhân bạch biến thể khu trú tại Bệnh viện Da liễu Trung ương từ 7/2019 – 9/2021. Đánh giá đáp ứng dựa trên mức thay đổi VASI trước và sau điều trị: đáp ứng rất tốt (76 – 100%), đáp ứng tốt (51 – 75%), đáp ứng trung bình (26 – 50%), đáp ứng kém (0 – 25%).

Kết quả: Sau 12 tuần điều trị, 53,3% số bệnh nhân đáp ứng tốt và rất tốt, 26,7% đáp ứng trung bình, 20% đáp ứng kém. Đáp ứng điều trị tăng lên theo thời gian, tỷ lệ đáp ứng rất tốt tăng từ 0 lên 20%, tỷ lệ đáp ứng tốt tăng từ 10% lên 33,3% sau 6 tuần và 12 tuần. Tác dụng không mong muốn xuất hiện ở 43,3% số bệnh nhân, gồm đỏ rát (43,3%), ngứa (10%) và phỏng nước (6,7%), đều ở mức độ nhẹ.

Kết luận: Phương pháp phối hợp bôi tacrolimus và chiếu đèn excimer có hiệu quả và an toàn trong điều trị bạch biến thể khu trú.
BỆNH U LYMPHO T DẠNG VIÊM MÔ MỠ DƯỚI DA
Authors: Lê Thị Thanh Hằng , Trần Thị Vân Anh
Published: June 2022

Subcutaneous panniculitis like T-cell Lymphoma (SPTCL) - U lympho T dạng viêm mô mỡ dưới da là bệnh lý u lympho Tnguyên phát tại da có biểu hiện lâm sàng giống viêm mô mỡ dưới da, đặc trưng bởi nhiểu nốt hoặc các mảng thâm nhiễm dưrới da, thường xuất hiện ở các chi và thường tiên lượng xấunếu có kèm theo hội chứng thực bào máu. Năm 2008, WHO chính thức phân loại bệnh ra làm hai thểlâm sàng: u lympho T dạng viêm mô mỡ dưới da nhỏm alpha/beta và nhóm gamma/delta [1].
Peranan Administrasi Pendidikan dalam Meningkatkan Profesionalisme Guru Pendidikan Agama Islam (PAI) pada MTs DDI Cilellang Kabupaten Barru
Authors: Salmiati Salmiati , Septiawansyah Riyang
Published: June 2022

This research discusses the role of educational administration, in this case, the learning device as an effort to increase Islamic education teacher professionalism at MTs DDI Cilellang, Barru Regency. The aims are to analyze: 1) the state of educational administration made by the teacher; 2) the form of teacher professionalism; and 3) the contribution of educational administration in increasing teacher professionalism. The type of this research is qualitative with descriptive method. Informants in this research were teachers of Al-Qur’an-Hadis, teachers of Akidah Akhlak, teachers of Fikih, and teachers of Islamic Culture History (SKI) at MTs DDI Cilellang, Barru Regency. The results showed that the state of teacher education administration at MTs DDI Cilellang, Barru Regency was complete and was well applied in the learning process in the classroom. The form of teacher professionalism is carrying out duties, roles, and responsibilities as teachers well. The contributions of educational administration in developing teacher professionalism at MTs DDI Cilellang, Barru Regency are five, namely: (1) time management, (2) class management, (3) stimulating to innovate, (4) stimulating to develop technical skills, (5) and the concept of transformation of students.
Peranan Pendidikan Akhlak dalam Mengembangkan Kepribadian Peserta Didik di Madrasah Aliyah Negeri 1 Parepare
Authors: Idris Djamaluddin M , Usman Usman
Published: June 2022

The purpose of this study was to analyze the role of moral education in developing the personality of students in Madrasah Aliyah Negeri 1 Parepare which focused on 1) the implementation of moral education in developing the personality of students; 2) contribution of moral education in developing the personality of students; and 3) supporting and inhibiting factors to the implementation of moral education in developing the personality of students. This type of research is qualitative. The source of the data came from respondents consisting of faith-moral (akidah akhlak) teachers and some students from Madrasah Aliyah Negeri 1 Parepare. Data are collected through observation, interviews, and documentation. Then analyzed through three stages: data reduction, data display, and conclusion. The results showed that the implementation of moral education in Madrasah Aliyah Negeri 1 Parepare uses two forms of learning, namely classroom learning and learning outside the classroom. The contributions of moral education in developing the personality of students are 1) as a filter of negative influences from outside and 2) as fostering students’ faith and moral values so that they determine their attitudes and behavior. Supporting factors for the implementation of moral education in developing the personality of students in the Madrasah Aliyah Negeri 1 Parepare are 1) professional teaching staff; 2) good cooperation from all stakeholders; 3) facilities and infrastructure. The inhibiting factors are 1) lack of religious education in the family and attention from parents; 2) heterogeneity of environmental conditions of students; and 3) lack of awareness of students.
Fitrah Perspektif Hadis dan Implikasinya terhadap Konsep Pendidikan Islam Mengenai Perkembangan Manusia
Authors: Rosdiana Rosdiana , Muzakkir Muzakkir
Published: June 2022

This study discusses fitrah in hadith perspective which is divided into three research focuses, namely 1) the quality and understanding of hadith about fitrah; 2) the relevance of hadith about fitrah to the theory of human development; and 3) fitrah as the concept of Islamic education. This research is a study of thematic hadith. Starting with takhrij-hadith, i’tibar-sanad, hadith criticism, hadith understanding, and development analysis about fitrah as the concept of Islamic education in constructing human development system through education. The results indicate that the quality of the hadith about fitrah is sahih. Fitrah according to the hadith is the initial condition (creation) or the origin of human born in an Islamic (muslim). Various developments or deviations from Islamic fitrah are the responsibility of parents (educators) as an educational environment. Various views of the flow of education regarding the theory of human development are refined by the concept of Islamic thought contained in the hadith about fitrah. There is a correlation between the potential (innate) of children and the environment in their development. Where the orientation of development must be based on Ilahiah values without forgetting the biological side. That the fitrah is the potential that brings humanity to be happy in the world and fortunate in the hereafter. Fitrah has an inseparable correlation with Islamic education because it is a basic human potential to be developed in order to optimize functions and achieve the goal of human creation through education so that fitrah becomes a basic in designing Islamic education.
Penerapan Nilai-nilai Tasawuf dalam Pembinaan Akhlak Santri pada Pondok Pesantren Miftahul Huda Gading Malang
Authors: Yasin Nur , Sutiah Sutiah
Published: June 2022

This study aims to find out (1) the program of implementing Sufism values in the moral development of santri at Miftahul Huda Gading Malang Islamic Boarding School; (2) the process of implementing Sufism values in the moral development of santri at Miftahul Huda Gading Malang Islamic Boarding School; and (3) the success of Sufism values in the moral development of santri at Miftahul Huda Gading Malang Islamic Boarding School. The type of study is a case study with the qualitative method. The data collection uses the method of observation, interviews, and documentation. As for the data analysis using a case study qualitative analysis. The results show that the implementing Sufism values in the moral development of santri Miftahul Huda Islamic Boarding School have three programs: (1) Diniyah formal namely Madrasah Matholiul Huda with the Sufism curriculum that obligatory follow for every santri; (2) Nonformal learning namely cottage learning in outside the formal time which took place in the mosque, hall and in the house of the caregiver; (3) Toriqoh namely toriqoh qodiriyah wa naqsabandiyah followed only by santri who fulfilled the requirements. While the process of implementing the values of Sufism in the moral development of santri at Miftahul Huda Islamic Boarding School (a) through habituation of dhikr to fard prayer, (b) uswatun hasanah or caregiver status, (c) tasawuf through education, and (d) toriqoh. The success implementing Sufism values in the moral development of santri Miftahul Huda Islamic Boarding School is characterized by changes in santri’s behavior and attitudes or can be judged by the evaluation of Bloom, namely cognitive, affective, and psychomotor.
NEW APPROACH TO STRONG EARTHQUAKE PREDICTION IN THE SOUTH BAIKAL REGION ON THE BASIS OF ROCK DEFORMATION MONITORING DATA: METHODOLOGY AND RESULTS
Authors: Bornyakov S. A. , Miroshnichenko A. I. , Vstovsky G. V. , Sintsov A. E. , Salko D. V.
Published: June 2022

The Southern Baikal is located within the actively developing Baikal rift zone (BRZ) that is characterized by a significant seismic potential, and M>7 earthquakes occur periodically with intensive shaking in the epicenters (up to 10 units). The problem of prediction and forecasting of strong earthquakes has always been critical for this region, considering its increasing urbanization, industrial clusters and transport systems. The article describes the methodology based on rock deformation monitoring data, which aims at developing a technology capable of efficient prediction and forecasting of strong earthquakes. In the Institute of Earth’s Crust SB RAS a set of studies is carried out in order to solve this problem, including those associated with the instrumental study of current movements of the lithosphere through GPS geodesy and deformations of rocks by strain gauges. The existing GPS sites and deformation measurements are combined into the Large-Scale Research Facilities "South Baikal instrumental complex for monitoring hazardous geodynamic processes" in frame of the Shared Research Facilities "Geodynamics and Geochronology" at the Institute of the Earth’s Crust, Siberian Branch of the Russian Academy of Science.

In this article, the deformation monitoring methodology is described in application to the monitoring sites installed in the study area. The description includes the details of its conceptual basis, technical support and data processing methods. The discussion focuses on the instrumental measurements of rock deformation related to three strong events in the study area – Kultuk (August 27, 2008), Bystrinskoe (September 21, 2020), and Kudara (December 10, 2020) earthquakes. The features of the deformation process before these seismic events are given special attention with account of the structural-geodynamic settings and positions of local monitoring sites relative to the earthquake epicenters.
The Effect of Perphenazine Add-On Therapy to Matrix Intervention on Control of Craving and Relapse in Methamphetamine Users: A Randomized Controlled Trial
Authors: Nasr Valli Alla , Salehi Mehrdad , Kheirabadi Gholamreza
Published: June 2022

Background: Compulsive behaviors, loss of control, and social and occupational dysfunctions are complications of methamphetamine dependence. Objectives: This study aimed to investigate the effectiveness of perphenazine on control of craving and relapse in methamphetamine users. Patients and Methods: This double-blind randomized controlled trial was performed in 2017 - 2018 in Isfahan, Iran. The samples included 40 methamphetamine-dependent subjects referred to drug rehab centers in Isfahan. While the intervention group received perphenazine for eight weeks, the control group received placebo tablets. Also, both groups were followed up for four months. Cocaine Craving Questionnaire-Brief (CCQ-Brief) was filled for each patient before and after the intervention. The comparison were conducted using the repeated measures analysis of covariance (ANCOVA). All analyses were performed by SPSS 20 Software. A P-value equal to 0.05 was considered as significant. Results: CCQ-Brief scores were significantly lower in the intervention group compared to the control group (P < 0.0001). The changes in CCQ-Brief scores were also significant among both groups. Conclusions: Adding perphenazine to the matrix program in the treatment of methamphetamine use disorder showed significant effect on the reduction of the craving to methamphetamine.
At tage plads i andres kulturhistoriske helligdom
Authors: Romme Larsen Birgitte
Published: June 2022

Artiklen bygger på en antropologisk undersøgelse om ’udflytningen af statslige arbejdspladser’ fra København til provinsen i form af et etnografisk casestudie af statsinstitutionen Notas omplacering til Nakskov på Vestlolland. Belyst fra et samtidigt arbejdsplads- og lokalsamfundsperspektiv og med udgangspunkt i materialitet og tidslighed og disses forbundethed analyseres det, hvordan Notas indflytning i akkurat byens tidligere rådhusbygning får betydning for lokalsamfundets modtagelse af arbejdspladsen og hermed også for indretningen af dennes nye dagligdag. Mens det er med tanke på Danmarks samlede fremtid, at Nota må ”flytte ud”, viser artiklen omvendt, hvordan det i høj grad bliver med tanke for Nakskovs kulturhistorie og lokale kollektive erindring som forhenværende selvstændig bykommune, at Nota må flytte ind.
Turystyczne wykorzystanie oznaczeń granic w Polsce = Tourist use of border markers in Poland
Authors: Więckowski Marek
Published: June 2022

Contemporary and relict borders have recently emerged as tourist attractions in their own right – to the extent that specific tourist products have even been made ready on the basis of them. This article has turned its attention to the marking of borders and the way this acts in support of the tourism-related objectives now seen to represent a novel function served by borders. Specifically, results are presented here in relation to the marking and delimitation of borders of Poland both past and present. The most in-depth analysis was then based around four case studies, i.e. one for each of the following identified periods in existence of given borders in operation at one time or another on the Polish lands. The research sustained several key conclusions, in line with which it has been worth stressing that each of the examples or aspects of border marking serves, not only as a factual tourist attraction, but also as a significant message conveyed. And what is being passed on in that way can be seen to have 3 key thrusts, i.e.: events from history, meaning old divisions (but also the loss of independence due to the Partitions of Poland, and its regaining, as well as the remembrance of heroes, changes to the lines followed by borders, and the associated regaining of land in the west, extending as far as the River Oder); local conditioning and the symbolic significance attachable to the most important border markings.
Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans
Authors: Wirak Gregory S , Florman Jeremy , Alkema Mark J , Connor Christopher W , Gabel Christopher V
Published: June 2022

In the aging brain, many of the alterations underlying cognitive and behavioral decline remain opaque. Caenorhabditis elegans offers a powerful model for aging research, with a simple, well-studied nervous system to further our understanding of the cellular modifications and functional alterations accompanying senescence. We perform multi-neuronal functional imaging across the aged C. elegans nervous system, measuring an age-associated breakdown in system-wide functional organization. At single-cell resolution, we detect shifts in activity dynamics toward higher frequencies. In addition, we measure a specific loss of inhibitory signaling that occurs early in the aging process and alters the systems’ critical excitatory/inhibitory balance. These effects are recapitulated with mutation of the calcium channel subunit UNC-2/CaV2α. We find that manipulation of inhibitory GABA signaling can partially ameliorate or accelerate the effects of aging. The effects of aging are also partially mitigated by disruption of the insulin signaling pathway, known to increase longevity, or by a reduction of caspase activation. Data from mammals are consistent with our findings, suggesting a conserved shift in the balance of excitatory/inhibitory signaling with age that leads to breakdown in global neuronal dynamics and functional decline.
Admixture of evolutionary rates across a butterfly hybrid zone
Authors: Xiong Tianzhu , Li Xueyan , Yago Masaya , Mallet James
Published: June 2022

Hybridization is a major evolutionary force that can erode genetic differentiation between species, whereas reproductive isolation maintains such differentiation. In studying a hybrid zone between the swallowtail butterflies Papilio syfanius and Papilio maackii (Lepidoptera: Papilionidae), we made the unexpected discovery that genomic substitution rates are unequal between the parental species. This phenomenon creates a novel process in hybridization, where genomic regions most affected by gene flow evolve at similar rates between species, while genomic regions with strong reproductive isolation evolve at species-specific rates. Thus, hybridization mixes evolutionary rates in a way similar to its effect on genetic ancestry. Using coalescent theory, we show that the rate-mixing process provides distinct information about levels of gene flow across different parts of genomes, and the degree of rate-mixing can be predicted quantitatively from relative sequence divergence (FST) between the hybridizing species at equilibrium. Overall, we demonstrate that reproductive isolation maintains not only genomic differentiation, but also the rate at which differentiation accumulates. Thus, asymmetric rates of evolution provide an additional signature of loci involved in reproductive isolation.
Post-qualitative seductions: (Re)turning research(er) bodies
Authors: Carey Neil , Benozzo Angelo
Published: June 2022

The contribution is an uncertain experiment; a series of fractured and fabulated video (re)turnings that tell on and in the seductive forces making (im)possible claims to know, and takes the form of fragmentary visual re-tellings of the becoming research(er) body.  These visual re-tellings are assembled in video format and can be viewed at this link https://youtu.be/aulMQNEDhGo .  This ‘paper’ contributes to ongoing debates that seek shifts from representationalist research foundations. The (re)turnings (the visual re-tellings) offered here pose questions of what is at stake for qualitative researchers in (dis)claiming the ‘I’ that legitimates them as researching bodies; they expose the limits of reason, the precarity of being thus – seduced by and in discipline, reason and rigor, and contained in and by bodies of research.
Leptin administration does not influence migratory behaviour in white-throated sparrows (Zonotrichia albicollis)
Authors: Churchman Emma , MacDougall-Shackleton Scott A.
Published: June 2022

Migratory flights by birds are among the most energetically demanding forms of animal movement, and are primarily fueled by fat as an energy source. Leptin is a critical fat-regulation hormone associated with energy balance in non-avian species but its function in birds is highly controversial. Prior research indicated the effects of leptin differed between birds in migratory condition or not, but no research has assessed the effect of leptin on migratory behaviour itself. In this study, our objective was to determine if leptin affects migratory restlessness and fat deposition in migratory songbirds. We used photoperiod manipulation to induce spring migratory condition, and measured migratory restlessness in leptin-injected and saline-injected white-throated sparrows (Zonotrichia albicollis). Leptin treatment had no effect on migratory restlessness nor fat deposition, providing evidence that leptin does not influence avian migratory motivation or behaviour. Our results also further support the idea that birds in a hyperphagic migratory condition may be insensitive to leptin.
Pensamientos amazónicos e intensidades icónicas. El devenir animal entre Deleuze-Guattari, Derrida y Viveiros de Castro.
Authors:   Universidad Alberto Hurtado (Santiago de Chile), Vignola Jacopo
Published: June 2022

El diálogo entre Derrida y el pensamiento amazónico remonta a De la gramatología, cuestionando el etnocentrismo subyacente a la interpretación lévi-straussiana del aprendizaje escrito de los nambikwara. Por su parte, Deleuze y Guattari defienden una desterritorialización mutua entre hombre y animal que, mediante la tensión entre ‘mayor’ y ‘menor’, marca la posibilidad de nuestros devenires. Solo lo menor constituye un devenir-del-pensamiento capaz de promover imprevisibles manifestaciones de vida. A pesar de una cierta lejanía de Derrida frente al devenir-animal deleuze-guattariano, relacionaremos este último con la superación derridiana del dualismo animal/hombre, a partir del “perspectivismo amerindio” (de Castro, 2013). Éste, en la perspectiva yanomami, logra hacer de la heterogeneidad entre ‘sensible’ e ‘inteligible’, un puente comunicativo entre la teoría derridiana de la escritura y lo anómalo deleuziano como devenir-menor del pensamiento. Finalmente, las intensidades icónicas del chamanismo baniwa acercarán el perspectivismo amerindio a la horizontalidad del devenir-menor deleuziano.
El instante de legibilidad del pensar en obra, una práctica escritural filosófica
Authors:   Claustro de Doctores de la Universidad de Barcelona (España), Hernández Gutiérrez Luis Eduardo
Published: June 2022

El presente ensayo configura una constelación de imágenes del pensar en obra, principalmente desde Nietzsche, Benjamin y Foucault, teniendo a la vista el concepto de política de la experiencia figurado por Miguel Morey. Se muestran algunos referentes críticos al Biopoder y a la Biopolítica, sobre todo la idea de progreso del orden burgués decimonónico en medio de la reproducción técnica de la mercancía y sus consecuencias. Se muestra una posibilidad de figuración del instante de legibilidad desde el Eterno Retorno, el Jetztzeit y la Militancia cínica, para darle forma a un esquema que reúna doctrina y práctica filosófica, asumiendo el esfuerzo expresivo de una escritura que aprehende y construye esos instantes de interrupción del pensar que podrían generar una experiencia genuina y singular para una vida otra
Análisis de algunos componentes textuales del proyecto de tesis doctoral en Educación: título, justificación del problema y recurso a otros textos
Authors:   Universidad Nacional de Cuyo (Argentina), Difabio de Anglat Hilda
Published: June 2022

El proyecto de tesis doctoral es un texto de importancia en tanto garantía de que las decisiones respecto de la fase teórica, la formulación de los objetivos, los métodos propuestos, estén debidamente alineadas con las prácticas de la buena investigación. Sin embargo, no es un género explícitamente bajo examen, escrutinio inexistente en el caso de propuestas de formalidad pedagógica. En este trabajo analizamos, desde encuadres teóricos y procedimientos analíticos probados, 31 proyectos de dos doctorados en Educación de la Universidad Nacional de Cuyo y de la Universidad Católica de Cuyo, Argentina, con el objeto de explorar qué clases de títulos aparecen, cómo se justifica el problema y qué modalidades adopta la incorporación de otros textos (citación y referenciación). Se seleccionan estos componentes textuales porque son los que se asocian directamente con la lógica inicial de una investigación, cuya relevancia reside en que es el requisito sine qua non que debe satisfacer un proyecto para ser aprobado. Los resultados muestran que las clases de títulos configuran un conjunto restringido en el que prevalece la construcción nominal que anuncia el tema; la justificación del problema aparece como un área débil, con preeminencia de la basada en su importancia y en el aporte de los hallazgos; prima la función atributiva de la citación, esto es, la cita asociada a un uso enciclopédico de las publicaciones referidas.
Relaciones entre aspecto y modalidad epistémica: algunas consecuencias de las restricciones temporales sobre la evaluación de predicados
Authors:   Universidad de Playa Ancha (Chile), Jaque Hidalgo Matías
Published: June 2022

En este trabajo examinamos la restricción aspectual que bloquea la lectura modal epistémica orientada al presente en predicados no estativos, patrón que se verifica en distintos contextos gramaticales del español, en el que aquí nos concentramos, y otras lenguas. Proponemos, desde un marco de análisis semántico y sintáctico de tipo formalista, que esta restricción se deriva de las condiciones temporales de evaluación de los distintos predicados y su posibilidad de coordinarse con el momento de habla puntual: los estados pueden ser evaluados en puntos de tiempo, mientras los eventos requieren para ello un intervalo (Hallman, 2010). El artículo desarrolla las consecuencias empíricas de esta idea, aduciendo la necesidad de distinguir dos clases de estados: estados puros y de intervalo (Dowty, 1979; Jaque, 2014). Finalmente, se presentan los correlatos formales que la hipótesis tiene en la representación sintáctico-semántica de la frase verbal.
Understanding the Inflammatory Biomarkers in Patients with Acrochordons: A Case-control Study
Authors: Patel Kinjal Prahaladbhai , Nilayangode Haridas Neelakandan , Nair Pragya Ashok
Published: June 2022

Introduction: Acrochordons kown as Skin Tags (ST) are common benign skin tumours usually occurring on the neck and major flexors of older and obese people. A few studies with conflicting results have been reported regarding the abnormalities of carbohydrate or lipid metabolisms, and the involvement of some inflammatory markers in patients with acrochordons. Aim: Comparison of Fasting Blood Sugar (FBS), lipid profile, and C-Reactive Protein (CRP) between patients with acrochordon, and healthy controls. Materials and Methods: The case-control study was conducted in the Department of Biochemistry and Dermatology of Pramukhswami Medical College, Karamsad, Gujarat, India. A total number of 160 subjects (80 healthy controls and 80 cases with acrochordons) were included. The FBS, lipid profile, and CRP were measured. Statistical analysis was performed by Independent t-test, one-way Analysis of Variance (ANOVA), frequency, descriptive statistics and Pearson’s correlation coefficient (r). Results: Total 160 subjects were included in study, 80 in each case and control group (51 female and 29 male in both groups). Age and sex between two groups were matched with mean age 47.68 years. The mean FBS for cases and controls were 133.24 and 84.9 mg/dL respectively. The mean CRP for cases and controls were 17.33 and 1.66 mg/L respectively. Significant differences were recognised for means of BMI, FBS and CRP between two groups (p-value <0.001). These parameters had significant difference between two groups in aspect of various size, colour and number of acrochordons (p-value <0.001). Conclusion: Threat of progress of metabolic syndrome is significantly higher in patients with acrochordons. Among the many elements of inflammations and metabolic syndrome, BMI, CRP, lipid profile and plasma sugar are remarkably linked with acrochordons.
Crossword Puzzles- An Interesting Teaching Tool to Facilitate Teaching Learning Process in Undergraduate Students of Biochemistry
Authors: Maheshwari Amitkumar , Sadariya Bhavesh , Javia Hardikkumar N , Sharma Dinesh
Published: June 2022

Introduction: Traditional medical teaching emphasis more on didactic lectures where participation of students is minimum with lowest retention rate and it promotes the learning at the base of cognitive level. Teaching through crossword puzzles enhances active participation of students, evokes student’s interest, motivates them and enhance their critical thinking. Aim: To compare the effectiveness of crossword puzzle and traditional teaching method based on student’s performance and to evaluate perception of undergraduate medical students and faculties about crossword puzzle as a teaching learning method. Materials and Methods: The present study was a cross-sectional study which was conducted in the Department of Biochemistry, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India, among the first year MBBS students. Total 150 participants were selected. Suitable two topics from the syllabus were chosen. Crossword puzzle prepared by online tools was circulated to the students during lecture of biochemistry. Performance of students were assessed by 10 pre-validated Multiple Choice Questions (MCQs) based test on knows (K) and knows how (KH) levels for both teaching learning methods viz traditional method and crossword puzzle method. Student’s and teacher’s perception were also recorded using pre-validated questionnaire based on 5 point likert scale. Data was compiled and analysed in MS Excel. To test the significance difference between the averages scored by students, independent t-test was used at significant level p<0.05. Results: Average percentage score of students of crossword puzzle group was 97.1% in Diabetes Mellitus (DM) topic and 96.95% in Gout topic; which were significantly more than the average percentage scored by students of traditional method group (p<0.01). More than 80% students felt that crossword puzzles help in better understanding of the topics as well as in remembering the newer terminology. All the students and 79% teachers have suggested more use of crossword puzzles in teaching. Conclusion: Crossword puzzles improve learning through recreation and it breaks the monotony of traditional lectures. Crossword puzzle based teaching improves the student’s performance as compared to the traditional teaching.
Determination of Nutrient Content of Guava Cv. ‘Pant Prabhat’ Affected by Different Canopy Heights and Planting Densities
Authors: Prusty Reena , Kumar Rajesh , Chand Satish , Devi Pooja
Published: June 2022

The study was conducted to determine the changes in nutrient composition of both affected by canopy heights, planting densities, and their interactions in comparison with both rainy and winter seasons. The experiment was composed of 4 different canopy heights [1.25m (H1), 1.5m (H2), 1.75m (H3), and unpruned (H4)] and 3 planting densities [5555 (D1), 3333 (D2), and (D3) 4444 plants ha-1] with total 12 treatment combinations laid out in factorial RBD was conducted. Fruits from the winter season were high in the nutrient content than in the rainy season. Canopy height H1 (1.75 m) recorded the maximum N, P, K, Zn, Cu, Fe and Mn (1.43%, 0.40%, 1.22%, 2.31 ppm, 2.28 ppm, 2.50 ppm and 1.31 ppm) in the winter season while, in the rainy season, maximum (0.88%, 0.35%, 0.98%, 2.07 ppm, 1.92 ppm, 2.14 ppm, 1.05 ppm) canopy height H3 (1.75m). Planting density D2 (3333 plant ha-1) recorded the maximum nutrient content for both seasons. It is therefore concluded canopy height H1 (1.25m) with planting density D2 (3333 plant ha-1) is best for producing fruits with high nutrient content for the winter crops.
Morphology and Influence of Abiotic Factors on Magnaporthe grisea
Authors: Dagar Bintu , Kumar Rakesh , Malik Vinod Kumar , Verma Preety , Yadav Pankaj , Yadav Lokesh , Verma Tarun
Published: June 2022

The present study entitled “Studies on Magnaporthe grisea incitant of blast disease of pearl millet [Pennisetum glaucum (L.) R. Br.]” was conducted during the kharif 2019 at research farm, Department of Plant Pathology, CCS Haryana Agricultural University, Hisar. Pearl millet blast disease is a devastating fungal disease causing considerable yield losses. Blast of pearl millet incited by Magnaporthe grisea is the most widespread and destructive disease of pearl millet in India and other pearl millet growing area of the world. This disease is a major factor limiting full exploitation of high yield potential hybrids in India. In the present investigation, culture medium plays an important role in growth and sporulation of fungus. Among 5 media tested, rice meal agar was found most effective for all the 3 isolates of pearl millet blast were tested. Combined effect of temperature and relative humidity also play an important role in growth and spore germination of fungus. Among five combination of temperature and relative humidity, 30℃ temperature with 100 % relative humidity was found most effective for spore germination.
Pigmented Bowen Disease of the Nail Unit
Authors: Lewis Daniel J. , Miller Christopher J. , Rubin Adam I.
Published: June 2022

This case report describes a black and red, hyperkeratotic scaly thin plaque with irregular borders on the proximal and lateral nail folds of the right third toe.
Eliminating the Reverse ISC Bottleneck of TADF Through Excited State Engineering and Environment‐Tuning Toward State Resonance Leading to Mono‐Exponential Sub‐µs Decay. High OLED External Quantum Efficiency Confirms Efficient Exciton Harvesting
Authors: Yersin Hartmut , Czerwieniec Rafał , Mataranga‐Popa Larisa , Mewes Jan‐Michael , Cheng Gang , Che Chi‐Ming , Saigo Masaki , Kimura Shuji , Miyata Kiyoshi , Onda Ken
Published: June 2022

The electronic structure and photophysics of the recently designed organic direct singlet harvesting (DSH) molecule are explored, in which donor (D) and acceptor (A) are held at distance by two bridges. One of the bridges is functionalized with fluorene. This structure leads to an ultrasmall singlet–triplet energy gap of ∆E (S1−T1) ≈ 10 cm−1 (≈1 meV) between the charge transfer states 1,3CT and shows an energetically close‐lying 3ππ* state localized on fluorene. Dielectric constant variation of the environment leads to state crossing of 3ππ* and 1,3CT near ε = 2.38 (toluene), as confirmed through time‐dependent density functional theory (DFT) and state‐specific DFT/polarizable continuum model excited‐state calculations. Transient absorption (TA) and time‐resolved luminescence in the femtosecond to microsecond regimes show rates of intersystem crossing (ISC) and reverse ISC (rISC) of >109 s–1. Thus, a strictly mono‐exponential short‐lived photo‐luminescence decay (431 ns) is observed, revealing that rISC is no longer the bottleneck responsible for long thermally activated delayed fluorescence. Ultrafast TA displays a time constant of ≈700 fs, representing the relaxation time of DSH and its solvent environment to the relaxed 1CT state with a molecular dipole moment of ≈40 D. Importantly, OLED devices, emitting sky‐blue light and showing high external quantum efficiency of 19%, confirm that singlet and triplet excitons are harvested efficiently.
Graphite Recycling from End‐of‐Life Lithium‐Ion Batteries: Processes and Applications
Authors: Abdollahifar Mozaffar , Doose Stefan , Cavers Heather , Kwade Arno
Published: June 2022

The number of lithium‐ion batteries (LIBs) from hybrid and electric vehicles that are produced or discarded every year is growing exponentially, which may pose risks to supply lines of limited resources. Thus, recycling and regeneration of end‐of‐life LIBs (EoL‐LIBs) is becoming an urgent and critical task for a sustainable and environmentally friendly future. In this regard, much attention, especially in industry, is expended for developing recycling of cathode materials and the other valuable materials, but not much attention is dedicated to the recycling and reuse of graphite (Gr) from EoL‐LIBs. Herein, the current status of EoL‐LIB regeneration is summarized, with a focus on the recycling and purification of Gr, a state‐of‐the‐art anode material for most of the commercial LIBs. According to the recent advances regarding Gr recycling, three major regeneration processes of Gr are categorized, including i) washing Gr with different solvents, ii) thermal treatment process, and iii) hybrid (chemical and thermal) treatment processes. Depending on the source of the LIBs, and the method and quality of separation and purification, the recycled Gr can be reutilized as an active material for battery industries, including graphene production, as well as many other alternative applications, which are also addressed here.
High Performance NIR OLEDs with Emission Peak Beyond 760 nm and Maximum EQE of 6.39%
Authors: Zhang Hongyang , Chen Zhao , Zhu Longzhi , Wu Yongquan , Xu Yuqing , Chen Shuming , Wong Wai‐Yeung
Published: June 2022

Advances in achieving high external quantum efficiency (EQE) of near‐infrared (NIR) organic light‐emitting diodes (OLEDs) are lagging behind that of the visible‐light OLEDs, according to the energy gap law. Herein, two structurally simple NIR‐phosphorescent Ir(III) complexes, DTCNIr and PTCNIr, with the cyclometalated ligands functionalized by the 1‐phenylisoquinoline‐4‐carbonitrile moiety and thieno/benzo[b]thiophene moiety are handily accessed within three synthetic steps. The introduction of the cyano unit can significantly lower the lowest unoccupied molecular orbitals whereas incorporating the conjugated group can elevate the highest occupied molecular orbitals of the newly designed Ir(III) complexes. The intramolecular charge transfer (ICT) transitions are enhanced due to the increased donor–acceptor interaction inside the metallophosphor. As a result, the emissions are red‐shifted to the NIR region with fast radiative decay. A maximum external quantum efficiency (EQE) of 8.11% with the emission peak at 726 nm for DTCNIr and a maximum EQE of 6.39% with the emission peak at 763 nm for PTCNIr are achieved in the NIR OLEDs by using these Ir(III) materials as the dopant emitters, a champion efficiency in the Ir(III)‐based OLEDs with the emission peak exceeding 760 nm.
Piezoelectric Polymeric Foams as Flexible Energy Harvesters: A Review
Authors: Ansari Manauwar Ali , Somdee Patcharapon
Published: June 2022

Piezoelectric energy harvesters (PEHs) have the potential to power low‐power electronic devices and can advance, self‐powered, autonomous electronics to the next level. Conventional ceramic‐based piezoelectrics have various properties such as fragility, rigidity, toxicity, high density, and lack of design flexibility which limit their use in more flexible environments. A ton of research has been carried out and published on novel piezomaterials, their transduction mechanisms, analytical models, and electrical circuits to improve various aspects of PEHs. Among these materials, studies on polymeric cellular (or foamed) ferroelectrets or piezoelectrets as PEHs have grown significantly since their discovery. Also, very limited or short reviews are available covering only few aspects. There is a necessity of recognizing their past and present advances in their various generation technology and polymer systems. Herein, a broader review of almost all conventional and recent polymeric foam‐based piezoelectrics for PEH applications is summarized. These cellular polymer piezoelectric systems either in bulk, composite, layered, or film form can be fabricated, and depending on the application and conditions, different polymers groups, mainly, polyolefins, polyester, fluoropolymer, and others, are considered. Their applications and future perspectives are also presented and discussed.
Compound heterozygous variants of the NARS2 gene in siblings with developmental delay, epilepsy, and neonatal diabetes syndrome
Authors: Yagasaki Hideaki , Sano Fumikazu , Narusawa Hiromune , Watanabe Daisuke , Kaga Yoshimi , Kobayashi Koji , Asano Yoshihiro , Nagata Miho , Yonei Ayumi , Inukai Takeshi
Published: June 2022

Neonatal diabetes mellitus (NDM) with developmental delay and epilepsy is classified as developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome. The majority of DEND syndrome are due to severely damaging variants of K‐ATP channels, and few mitochondria‐related genes have been reported. We report here two Japanese siblings who were clinically diagnosed with DEND syndrome in whom NARS2 compound heterozygous variants were detected. Patient 1 was a 3‐year‐old girl and presented with diabetes ketoacidosis at 3 months old. Patient 2 was a 1‐year‐old boy who presented with severe hyperglycemia and started insulin therapy at 3 days old. After the first episodes, they both presented with severe developmental delay, hearing loss and treatment‐resistant epilepsy accompanied by progressive brain atrophy. Whole‐exome sequencing revealed compound heterozygous NARS2 p.R159C and p.L217V variants, and the GATA4 p.P407Q variant in both patients. They were treated by mitochondrial supportive therapy of vitamin B1, L‐carnitine, and coenzyme Q10. Patient 2 was withdrawn from insulin therapy at 6 months old. This is the first report of NDM in which variants of the NARS2 gene coding mitochondrial protein were detected. Genetic analysis including mitochondrial genes should be considered in patients with neonatal onset diabetes associated with neurogenic symptoms.
Longitudinal Retinal Changes in MOGAD
Authors: Oertel Frederike Cosima , Sotirchos Elias S. , Zimmermann Hanna G. , Motamedi Seyedamirhosein , Specovius Svenja , Asseyer Eva Susanna , Chien Claudia , Cook Lawrence , Vasileiou Eleni , Filippatou Angeliki , Calabresi Peter A. , Saidha Shiv , Pandit Lekha , D'Cunha Anitha , Outteryck Olivier , Zéphir Hélène , Pittock Sean , Flanagan Eoin P. , Bhatti M. Tariq , Rommer Paulus S. , Bsteh Gabriel , Zrzavy Tobias , Kuempfel Tania , Aktas Orhan , Ringelstein Marius , Albrecht Philipp , Ayzenberg Ilya , Pakeerathan Thivya , Knier Benjamin , Aly Lilian , Asgari Nasrin , Soelberg Kerstin , Marignier Romain , Tilikete Caroline Froment , Cobo Calvo Alvaro , Villoslada Pablo , Sanchez‐Dalmau Bernardo , Martinez‐Lapiscina Elena H. , Llufriu Sara , Green Ari J. , Yeaman Michael R. , Smith Terry J. , Brandt Alexander U. , Chen John , Paul Friedemann , Havla Joachim ,   with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group
Published: June 2022

Objective

Patients with myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro‐axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON‐independent retinal atrophy can be detected in MOGAD.

Methods

Eighty patients with MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired with (1) Spectralis spectral domain OCT (MOGAD: N = 66 and HCs: N = 103) and (2) Cirrus high‐definition OCT (MOGAD: N = 14 and HCs: N = 36). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were quantified.

Results

At baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD‐ON) compared with MOGAD eyes without a history of ON (MOGAD‐NON) and HCs (p < 0.001). MOGAD‐NON eyes had lower GCIPL volume compared to HCs (p < 0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow‐up up to 3 years), MOGAD‐ON with ON within the last 6–12 months before baseline exhibited greater pRNFL thinning than MOGAD‐ON with an ON greater than 12 months ago (p < 0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with the HC cohort.

Interpretation

Our study suggests the absence of attack‐independent retinal damage in patients with MOGAD. Yet, ongoing neuroaxonal damage or edema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in patients with MOGAD. ANN NEUROL 2022;92:476–485