bluuebunny/crossref_metadata_2025 huggingface dataset:
Improvement of the qualification system in Korea for foreign nurses eligible to take Korean nursing licensing examination
Authors: Lee Young Whee , Suh Yeon Ok , Chae Kyoung Sook
Published: September 2019

Purpose: We aimed to review and provide a quality improvement for the document utilized by the relevant Korean government body to verify and evaluate foreign university/college graduates’ eligibility for nursing and qualification to take the Korean nursing licensing examination.Methods: This was a descriptive study. We analyzed the current Korean qualification system for foreign graduates to Korean nursing licensing examination and the same system utilized in some other countries. Then, we created a draft of the reviewed qualification standards document based on the 2 prior analyses and their comparisons, and applied a questionnaire in an open hearing with 5 experts to enhance the draft’s quality. Finally, we presented and discussed the final draft.Results: The reviewed criteria of the qualification standards included confirming whether the foreign graduate’s university has an accreditation provided by its relevant government body, the exclusion of foreign graduates’ provision of several documents previously required, a minimum number of credits (1,000 hours) for their original course, a 3-year minimum enrollment period for their original course, and a mandatory reassessment of the foreign graduates’ university recognition in a 5-year cycle.Conclusion: We believe that by creating a review draft that addresses the flaws of the current document utilized to determine the qualification for foreign graduates to take the Korean nursing licensing examination, we have simplified it for a better understanding of the application process. We hope that this draft will contribute to a more objective and equitable qualification process for foreign university nurse graduates in Korea.
Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China
Authors: Liu Ziyi , Xiao Xia , Li Yan , Liu Yuan , Li Ruichao , Wang Zhiqiang
Published: September 2019

Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks.
Reproductive Cold Stress Tolerance in Sorghum F1 Hybrids is a Heterotic Trait
Authors: Schaffasz André , Windpassinger Steffen , Snowdon Rod , Wittkop Benjamin
Published: September 2019

The sensitivity of sorghum to pre-flowering cold stress, resulting in reduced pollen viability and poor seed set, is a major constraint for expanding growing areas into higher altitudes and latitudes. Nevertheless, compared to juvenile cold tolerance, reproductive cold tolerance in sorghum has received much less attention so far, and very little is known about its inheritance in F1-hybrids. We have composed a representative factorial (n = 49 experimental F1-hybrids) for a comprehensive study on heterosis and combining ability for crucial tolerance traits as spikelet fertility (panicle harvest index), seed yield and pollen viability, using field trials in stress- and control environments in Germany and Mexico as well as climate chamber experiments. Our results indicate a heterotic and rather dominant inheritance of reproductive cold tolerance in sorghum, with strong effects of female general combining ability (GCA) on F1-hybrid performance in our material. These findings, together with the comparatively low contribution of specific combining ability (SCA) effects and high heritability estimates, suggest that robust and efficient enhancement of reproductive cold tolerance is feasible via hybrid breeding.
Laterality as a Tool for Assessing Breed Differences in Emotional Reactivity in the Domestic Cat, Felis silvestris catus
Authors: Wells Deborah L. , McDowell Louise J.
Published: September 2019

Cat breeds differ enormously in their behavioural disposition, a factor that can impact on the pet-owner relationship, with indirect consequences for animal welfare. This study examined whether lateral bias, in the form of paw preference, can be used as a tool for assessing breed differences in emotional reactivity in the cat. The paw preferences of 4 commonly owned breeds were tested using a food-reaching challenge. Cats were more likely to be paw-preferent than ambilateral. Maine Coons, Ragdolls and Bengals were more likely to be paw-preferent than ambilateral, although only the Bengals showed a consistent preference for using one paw (left) over the other. The strength of the cats’ paw use was related to cat breed, with Persians being more weakly lateralised. Direction of paw use was unrelated to feline breed, but strongly sex-related, with male cats showing a left paw preference and females displaying a right-sided bias. We propose that paw preference measurement could provide a useful method for assessing emotional reactivity in domestic cats. Such information would be of benefit to individuals considering the acquisition of a new cat, and, in the longer term, may help to foster more successful cat-owner relationships, leading to indirect benefits to feline welfare.
Frequency of Owner-Reported Bacterial Infections in Pet Guinea Pigs
Authors: Roberts-Steel Shannon , Oxley James A. , Carroll Aisling , Wills Alison P.
Published: September 2019

Domestic guinea pigs suffer morbidity and mortality due to a range of bacterial infections amongst other causes. Microorganisms such as Bordetella bronchiseptica and Streptococcus pneumoniae are commonly implicated in respiratory disease; however, there is a lack of research surrounding the prevalence of these bacterial infections. The aim of this study was to investigate the frequency with which owners reported bacterial infections in pet guinea pigs and to assess owner knowledge of correct husbandry practices to inform prevention of the development of bacterial infections. An online questionnaire, consisting of 30 questions was promoted to guinea pig owners. Of all respondents (n = 524), 39.39% reported that their guinea pig(s) had been clinically diagnosed with a bacterial infection, with upper respiratory tract infections the most commonly reported (46.95%), followed by urinary tract (15.49%) and then gastrointestinal infections (11.73%). Owners demonstrated knowledge of correct husbandry practices and there was no significant effect (p = 0.475) of owner knowledge on having owned a guinea pig with a bacterial infection. Bacterial infections may be more common in guinea pigs than was previously thought. Further research is required to understand why bacterial infections are common in pet guinea pigs and to help owners to prevent and recognize these infections.
Chrysophanol, Physcion, Hesperidin and Curcumin Modulate the Gene Expression of Pro-Inflammatory Mediators Induced by LPS in HepG2: In Silico and Molecular Studies
Authors: Selim Nabil Mohamed , Elgazar Abdullah Abdurrahman , Abdel-Hamid Nabil Mohie , Abu El-Magd Mohammed Rizk , Yasri Aziz , El Hefnawy Hala Mohamed , Sobeh Mansour
Published: September 2019

Hepatitis is an inflammatory condition that can develop hepatocellular carcinoma. Traditional medicine has always been the pillar of medical practice. However, it became less compatible with the current understanding of the diseases and the possible treatment. Therefore, in silico tools could be utilized for building the bridge between the legacy of the past and the current medical approaches allowing access to new therapeutic discoveries. In this work, a Chinese traditional medicine database was screened using structure-based virtual screening to identify molecules that could inhibit p38 alpha mitogen-activated protein kinase (MAPK). Out of the identified compounds, four selected compounds: chrysophanol, physcion, curcumin and hesperidin were isolated from their respective sources and their structures were confirmed by spectroscopic methods. These compounds decreased the gene expression of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1beta (IL-1β) in lipopolysaccharide (LPS) induced inflammation in a hepatocellular carcinoma cell line (HepG2) in a dose-dependent manner. The molecular docking study revealed the specificity of these compounds towards p38 MAPK rather than other MAPKs. In conclusion, the molecular and in silico studies suggest that the isolated compounds could be a potential treatment for hepatitis by resolving inflammation controlled by MAPKs, thus limiting the development of further complications and lower side effects.
Major Depressive Disorder and Oxidative Stress: In Silico Investigation of Fluoxetine Activity against ROS
Authors: Muraro Cecilia , Dalla Tiezza Marco , Pavan Chiara , Ribaudo Giovanni , Zagotto Giuseppe , Orian Laura
Published: September 2019

Major depressive disorder is a psychiatric disease having approximately a 20% lifetime prevalence in adults in the United States (U.S.), as reported by Hasin et al. in JAMA Psichiatry 2018 75, 336–346. Symptoms include low mood, anhedonia, decreased energy, alteration in appetite and weight, irritability, sleep disturbances, and cognitive deficits. Comorbidity is frequent, and patients show decreased social functioning and a high mortality rate. Environmental and genetic factors favor the development of depression, but the mechanisms by which stress negatively impacts on the brain are still not fully understood. Several recent works, mainly published during the last five years, aim at investigating the correlation between treatment with fluoxetine, a non-tricyclic antidepressant drug, and the amelioration of oxidative stress. In this work, the antioxidant activity of fluoxetine was investigated using a computational protocol based on the density functional theory approach. Particularly, the scavenging of five radicals (HO•, HOO•, CH3OO•, CH2=CHOO•, and CH3O•) was considered, focusing on hydrogen atom transfer (HAT) and radical adduct formation (RAF) mechanisms. Thermodynamic as well as kinetic aspects are discussed, and, for completeness, two metabolites of fluoxetine and serotonin, whose extracellular concentration is enhanced by fluoxetine, are included in our analysis. Indeed, fluoxetine may act as a radical scavenger, and exhibits selectivity for HO• and CH3O•, but is inefficient toward peroxyl radicals. In contrast, the radical scavenging efficiency of serotonin, which has been demonstrated in vitro, is significant, and this supports the idea of an indirect antioxidant efficiency of fluoxetine.
A 3D Simulation of Single-Channel High-Temperature Polymer Exchange Membrane Fuel Cell Performances
Authors: Yaghoub Abdollahzadeh Jamalabadi Mohammad , Ghasemi Milad , Alamian Rezvan , Afshari Ebrahim , Wongwises Somchai , Mehdi Rashidi Mohammad , Safdari Shadloo Mostafa
Published: September 2019

The fuel cell is an electrochemical energy converter that directly converts the chemical energy of the fuel into electrical current and heat. The fuel cell has been able to identify itself as a source of clean energy over the past few decades. In order to achieve the durability and stability of fuel cells, many parameters should be considered and evaluated Therefore, in this study, a single-channel high-temperature polymer exchange membrane fuel cell (HT-PEMFC) has been numerically simulated in three-dimensional, isothermal and single-phase approach. The distribution of the hydrogen and oxygen concentrations, as well as water in the anode and cathode, are shown; then the effect of different parameters of the operating pressure, the gas diffusion layer porosity, the electrical conductivity of the gas diffusion layer, the ionic conductivity of the membrane and the membrane thickness are investigated and evaluated on the fuel cell performance. The results showed that the pressure drop in the cathode channel was higher than the anode channel, so that the pressure drop in the cathode channel was higher than 9 bars but, in the anode channel was equal to 2 bars. By examining the species concentration, it was observed that their concentration at the entrance was higher and at the output was reduced due to participation in the reaction and consumption. Also, with increasing the operating pressure, the electrical conductivity of the gas diffusion layer and ionic conduction of the membrane, the performance of the fuel cell is improved.
Monitoring of Evolving Laser Induced Periodic Surface Structures
Authors: Lübcke Andrea , Pápa Zsuzsanna , Schnürer Matthias
Published: September 2019

Laser induced periodic surface structures (LIPSS) are generated on titanium and silicon nitride surfaces by multiple femtosecond laser pulses. An optical imaging system is used to observe the backscattered light during the patterning process. A characteristic fringe pattern in the backscattered light is observed and evidences the surface modification. Experiments are complemented by finite difference time domain numerical simulations which clearly show that the periodic surface modulation leads to characteristic modulations in the coherently scattered light field. It is proposed that these characteristic fringe pattern can be used as a very fast and low-cost monitor of LIPSS formation formation during the manufacturing process.
Understanding of Molecular Contribution of Quinhydrone/Methanol Organic Passivation for Improved Minority Carrier Lifetime on Nanostructured Silicon Surface
Authors: Choi Jea-Young
Published: September 2019

In this report, we present a study of the quinhydrone/methanol (QHY/MeOH) organic passivation technique for a silicon (Si) surface. The roles of p-benzoquinone (BQ) and hydroquinone (HQ), which make up QHY, in controlling the uniformity and coverage of the passivation layer as well as the minority carrier lifetime (τeff) of Si were investigated. The uniformity and coverage of the passivation layer after treatment with diverse mixture ratios of BQ and HQ in MeOH were studied with two different atomic force microscope (AFM) techniques, namely tunneling mode (TUNA) and high-resolution tapping mode AFM (HR-AFM). In addition, the τeff and surface potential voltages (SPV) of passivated surfaces were measured to clarify the relationship between the morphologies of the passivation layers and degrees of surface band bending. The molecular interactions between BQ and HQ in MeOH were also analyzed using Fourier-transform infrared spectroscopy (FT-IR). In our study, we successfully demonstrated the role of each molecule for effective Si surface passivation with BQ working as a passivation agent and HQ contributing as a proton (H+) donator to BQ for accelerating the passivation rate. However, our study also clearly revealed that HQ could also hinder the formation of a conformal passivation layer, which raises an issue for passivation over complex surface geometry, especially a nanostructured surface.
Vortex Identification across Different Scales
Authors: Schielicke Lisa , Gatzen Christoph Peter , Ludwig Patrick
Published: September 2019

Vortex identification in atmospheric data remains a challenge. One reason is the general presence of shear throughout the atmosphere that interferes with traditional vortex identification methods based on geopotential height or vorticity. Alternatively, kinematic methods can avoid some of the drawbacks of the traditional methods since they compare the rotational and deformational flow parts. In this work, we apply the kinematic vorticity number method ( W k -method) to atmospheric datasets ranging from the synoptic to the convective scales. The W k -method is tested for winter storm Kyrill, a high-impact extratropical cyclone that affected Germany in January 2007. This case is especially challenging for vortex identification methods since it produced a complex wind occurrence associated with a derecho along a narrow cold-frontal rain band and an area of high winds close to the low pressure center. The W k -method is able to identify vortices in differently-resolved datasets and at different height levels in a consistent manner. Additionally, it is able to determine and visualize the storm characteristics. As a result, we discovered that the total positive circulation of the vortices associated with Kyrill remains of similar order across different data sets though the vorticity magnitude of the most intense vortices increases with increasing resolution.
Application of Finite Element Analysis in Modeling of Bionic Harrowing Discs
Authors: Chirende Benard , Li Jian Qiao , Vheremu Wonder
Published: September 2019

Ansys software was used to carry out three-dimensional finite element analysis (FEA) for biomimetic design of harrowing discs based on the body surface morphology of soil burrowing animals like dung beetle (Dicranocara deschodt) which have non-smooth units such as convex domes and concave dips. The main objective was to find out the effects of different biomimetic surface designs on reducing soil resistance hence the horizontal force acting on the harrowing disc during soil deformation was determined. In this FEA, soil deformation was based on the Drucker–Prager elastic–perfectly plastic model which was applied only at the lowest disc harrowing speed of 4.4 km/h which is within the limits of model. The material non-linearity of soil was addressed using an incremental technique and inside each step, the Newton–Raphson iteration method was utilized. The model results were analyzed and then summation of horizontal forces acting on the soil-disc interface was also done. An experiment was then conducted in an indoor soil bin to validate the FEA results. The FEA results are generally in agreement with those of the indoor experiment with a difference of less than or equal to the acceptable 10% with an average difference of 4%. Overall, convex bionic units gave the highest resistance reduction of 19.5% from 1526.87 N to 1228.38 N compared to concave bionic units.
Effects of Transpulmonary Administration of Caffeine on Brain Activity in Healthy Men
Authors: Ueda Kazutaka , Nakao Masayuki
Published: September 2019

The present study aimed to examine the effect of transpulmonary administration of caffeine on working memory and related brain functions by electroencephalography measurement. The participants performed working memory tasks before and after vaporizer-assisted aspiration with inhalation of caffeinated- and non-caffeinated liquids in the caffeine and sham conditions, respectively. Transpulmonary administration of caffeine tended to increase the rate of correct answers. Moreover, our findings suggest that transpulmonary administration of caffeine increases the theta-band activity in the right prefrontal, central, and temporal areas during the task assigned post-aspiration. Our results may indicate an efficient and fast means of eliciting the stimulatory effects of transpulmonary administration of caffeine.
Revisiting Happiness and Well-Being in Later Life from Interdisciplinary Age-Studies Perspectives
Authors: Stončikaitė Ieva
Published: September 2019

Important demographic shifts and the so-called ‘longevity revolution’ have generated profound transformations in social interpretations of old age, an increased interest in age studies and new ideas on how to age well. The majority of current successful ageing models, however, represent rather a prevailing construct in Western societies. Physical and psychosocial well-being and the ability to adjust to the ideals of successful ageing are often seen as an integral part of a good quality in life. Those who do not or cannot follow these lines are often regarded as morally irresponsible and seem to be doomed to have a lonely, unhealthy and unhappy later life. This paper questions the current discourses of successful ageing in terms of healthy and happy living and calls for a reconsideration of more global, integrated and holistic understandings of the process of growing old.
What Is the Fuss about Integrins and the Tumor Microenvironment?
Authors: Eble Johannes A. , Gullberg Donald
Published: September 2019

In recent years the tumor microenvironment (TME) has received increasing attention [...]
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells
Authors: Martínez-Meza Samuel , Díaz Jorge , Sandoval-Bórquez Alejandra , Valenzuela-Valderrama Manuel , Díaz-Valdivia Natalia , Rojas-Celis Victoria , Contreras Pamela , Huilcaman Ricardo , Ocaranza María Paz , Chiong Mario , Leyton Lisette , Lavandero Sergio , Quest Andrew F.G.
Published: September 2019

The renin–angiotensin receptor AT2R controls systemic blood pressure and is also suggested to modulate metastasis of cancer cells. However, in the latter case, the mechanisms involved downstream of AT2R remain to be defined. We recently described a novel Caveolin-1(CAV1)/Ras-related protein 5A (Rab5)/Ras-related C3 botulinum toxin substrate 1 (Rac1) signaling axis that promotes metastasis in melanoma, colon, and breast cancer cells. Here, we evaluated whether the anti-metastatic effect of AT2R is connected to inhibition of this pathway. We found that murine melanoma B16F10 cells expressed AT2R, while MDA-MB-231 human breast cancer cells did not. AT2R activation blocked migration, transendothelial migration, and metastasis of B16F10(cav-1) cells, and this effect was lost when AT2R was silenced. Additionally, AT2R activation reduced transendothelial migration of A375 human melanoma cells expressing CAV1. The relevance of AT2R was further underscored by showing that overexpression of the AT2R in MDA-MB-231 cells decreased migration. Moreover, AT2R activation increased non-receptor protein tyrosine phosphatase 1B (PTP1B) activity, decreased phosphorylation of CAV1 on tyrosine-14 as well as Rab5/Rac1 activity, and reduced lung metastasis of B16F10(cav-1) cells in C57BL/6 mice. Thus, AT2R activation reduces migration, invasion, and metastasis of cancer cells by PTP1B-mediated CAV1 dephosphorylation and inhibition of the CAV1/Rab5/Rac-1 pathway. In doing so, these observations open up interesting, novel therapeutic opportunities to treat metastatic cancer disease.
Effect of Co-Feeding Inorganic and Organic Molecules in the Fe and Co Catalyzed Fischer–Tropsch Synthesis: A Review
Authors: Muleja Adolph Anga , Gorimbo Joshua , Masuku Cornelius Mduduzi
Published: September 2019

This short review makes it clear that after 90 years, the Fischer–Tropsch synthesis (FTS) process is still not well understood. While it is agreed that it is primarily a polymerization process, giving rise to a distribution of mainly olefins and paraffins; the mechanism by which this occurs on catalysts is still a subject of much debate. Many of the FT features, such as deactivation, product distributions, kinetics and mechanism, and equilibrium aspects of the FT processes are still subjects of controversy, regardless of the progress that has been made so far. The effect of molecules co-feeding in FTS on these features is the main focus of this study. This review looks at some of these areas and tries to throw some light on aspects of FTS since the inception of the idea to date with emphasis and recommendation made based on nitrogen, water, ammonia, and olefins co-feeding case studies.
Potential of Adult Endogenous Neural Stem/Progenitor Cells in the Spinal Cord to Contribute to Remyelination in Experimental Autoimmune Encephalomyelitis
Authors: Maeda Yuki , Nakagomi Nami , Nakano-Doi Akiko , Ishikawa Hiroto , Tatsumi Yoshiki , Bando Yoshio , Yoshikawa Hiroo , Matsuyama Tomohiro , Gomi Fumi , Nakagomi Takayuki
Published: September 2019

Demyelination and remyelination play pivotal roles in the pathological process of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), a well-established animal model of MS. Although increasing evidence shows that various stimuli can promote the activation/induction of endogenous neural stem/progenitor cells (NSPCs) in the central nervous system, the potential contributions of these cells to remyelination following inflammatory injury remain to be fully investigated. In the present study, using an adult mouse model of EAE induced by myelin oligodendrocyte glycoprotein (MOG) peptide, we investigated whether adult NSPCs in the spinal cord can lead to remyelination under inflammatory conditions. Immunohistochemistry showed that cells expressing the NSPC marker Nestin appeared after MOG peptide administration, predominantly at the sites of demyelination where abundant inflammatory cells had accumulated, whereas Nestin+ cells were rarely present in the spinal cord of PBS-treated control mice. In vitro, Nestin+ NSPCs obtained from EAE mice spinal cords could differentiate into multiple neural lineages, including neurons, astrocytes, and myelin-producing oligodendrocytes. Using the Cre–LoxP system, we established a mouse strain expressing yellow fluorescent protein (YFP) under the control of the Nestin promoter and investigated the expression patterns of YFP-expressing cells in the spinal cord after EAE induction. At the chronic phase of the disease, immunohistochemistry showed that YFP+ cells in the injured regions expressed markers for various neural lineages, including myelin-forming oligodendrocytes. These results show that adult endogenous NSPCs in the spinal cord can be subject to remyelination under inflammatory conditions, such as after EAE, suggesting that endogenous NSPCs represent a therapeutic target for MS treatment.
Human Immunodeficiency Virus (HIV) Infection and Use of Illicit Substances Promote Secretion of Semen Exosomes that Enhance Monocyte Adhesion and Induce Actin Reorganization and Chemotactic Migration
Authors: Lyu Yuan , Kaddour Hussein , Kopcho Steven , Panzner Tyler D. , Shouman Nadia , Kim Eun-Young , Martinson Jeremy , McKay Heather , Martinez-Maza Otoniel , Margolick Joseph B. , Stapleton Jack T. , Okeoma Chioma M.
Published: September 2019

Semen exosomes (SE) from HIV-uninfected (HIV−) individuals potently inhibit HIV infection in vitro. However, morphological changes in target cells in response to SE have not been characterized or have the effect of HIV infection or the use of illicit substances, specifically psychostimulants, on the function of SE been elucidated. The objective of this study was to evaluate the effect of HIV infection, psychostimulant use, and both together on SE-mediated regulation of monocyte function. SE were isolated from semen of HIV− and HIV-infected (HIV+) antiretroviral therapy (ART)-naive participants who reported either using or not using psychostimulants. The SE samples were thus designated as HIV−Drug−, HIV−Drug+, HIV+Drug−, and HIV+Drug+. U937 monocytes were treated with different SEs and analyzed for changes in transcriptome, morphometrics, actin reorganization, adhesion, and chemotaxis. HIV infection and/or use of psychostimulants had minimal effects on the physical characteristics of SE. However, different SEs had diverse effects on the messenger RNA signature of monocytes and rapidly induced monocyte adhesion and spreading. SE from HIV infected or psychostimulants users but not HIV−Drug− SE, stimulated actin reorganization, leading to the formation of filopodia-like structures and membrane ruffles containing F-actin and vinculin that in some cases were colocalized. All SE stimulated monocyte chemotaxis to HIV secretome and activated the secretion of matrix metalloproteinases, a phenotype exacerbated by HIV infection and psychostimulant use. SE-directed regulation of cellular morphometrics and chemotaxis depended on the donor clinical status because HIV infection and psychostimulant use altered SE function. Although our inclusion criteria specified the use of cocaine, humans are poly-drug and alcohol users and our study participants used psychostimulants, marijuana, opiates, and alcohol. Thus, it is possible that the effects observed in this study may be due to one of these other substances or due to an interaction between different substances.
Impact of Cholesterol on Ischemic Stroke in Different Human-Like Hamster Models: A New Animal Model for Ischemic Stroke Study
Authors: Wei Lili , Shi Haozhe , Lin Xiao , Zhang Xin , Wang Yuhui , Liu George , Xian Xunde
Published: September 2019

Rationale: While high low-density lipoprotein cholesterol (LDL-C) and low high-density lipoprotein cholesterol (HDL-C) levels are positively associated with cardiovascular events, it is still unclear whether familial hypercholesterolemia (FH) and Tangier’s disease (TD), caused by mutations in LDLR and ABCA1, respectively, influence ischemic stroke (IS) in humans. Objective: We sought to establish an easier, more effective, and time-saving method to induce IS, then studied the precise effects of different types of lipoproteins on IS. Methods and Results: A new technique termed contralateral middle cerebral artery occlusion (c-MCAO) was introduced to human-like hamster models to induce IS. Compared to traditional distal MCAO (d-MCAO) induced by electrocoagulation, c-MCAO resulted in a more severe IS with larger infarct sizes and more blood–brain barrier (BBB) disruption after 24 h. It was shown that c-MCAO markedly elicited an increase in brain infarct volume and BBB leakage in both homozygous LDLR (LDLR–/–) and ABCA1 knockout (ABCA1–/–) hamsters, but not in heterozygous LDLR knockout (LDLR+/–) hamsters when compared to wild-type (WT) controls. Conclusions: Using human-like genetically engineered hamsters, our findings demonstrated that both high LDL-C level caused by homozygous LDLR deficiency and severe low HDL-C level caused by deleting ABCA1 were risk factors of IS. As such, we believe the development of this novel IS hamster model is suitable for future ischemic/reperfusion studies.
Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment
Authors: Yamaguchi Seiji , Thi Minh Le Phuc , Ito Morihiro , Shintani Seine A. , Takadama Hiroaki
Published: September 2019

The main problem of orthopedic and dental titanium (Ti) implants has been poor bone-bonding to the metal. Various coatings to improve the bone-bonding, including the hydroxyapatite and titania, have been developed, and some of them have been to successfully applied clinical use. On the other hand, there are still challenges to provide antibacterial activity and promotion of bone growth on Ti. It was shown that a calcium-deficient calcium titanate coating on Ti and its alloys exhibits high bone-bonding owing to its apatite formation. In this study, Sr and Ag ions, known for their promotion of bone growth and antibacterial activity, were introduced into the calcium-deficient calcium titanate by a three-step aqueous solution treatment combined with heat. The treated metal formed apatite within 3 days in a simulated body fluid and exhibited antibacterial activity to Escherichia coli without showing any cytotoxicity in MC3T3-E1 preosteoblast cells. Furthermore, the metal slowly released 1.29 ppm of Sr ions. The Ti with calcium-deficient calcium titanate doped with Sr and Ag will be useful for orthopedic and dental implants, since it should bond to bone because of its apatite formation, promote bone growth due to Sr ion release, and prevent infection owing to its antibacterial activity.
Bifunctional TiO2/AlZr Thin Films on Steel Substrate Combining Corrosion Resistance and Photocatalytic Properties
Authors: Villardi de Oliveira Caroline , Alhussein Akram , Creus Juan , Schuster Frédéric , Schlegel Michel L. , Dong Zhili , Jiménez Carmen , Sanchette Frédéric
Published: September 2019

A novel multi-functional bilayer coating combining an anti-corrosion Al–Zr (4 at.% Zr) underlayer and an anti-biofouling TiO2 top layer was deposited on high-speed steel (HSS) substrates. Al–Zr (4 at.% Zr) film, deposited by DC magnetron sputtering, which is a single phased supersaturated solid solution of Zr in Al, is used to provide sacrificial corrosion resistance of steels and TiO2 is added as a top layer to induce photocatalytic activity and hydrophilic behavior which can generate antifouling properties in order to slow down the biofouling process. The top TiO2 films, deposited at 550 °C by AACVD (aerosol-assisted chemical vapor deposition), consisting of anatase TiO2 microflowers physically attached to the TiO2 thin films present a high decomposition rate of Orange G dye (780 × 10−10 mol L−1·min−1). The enhanced photocatalytic performance is associated with the rough network and the presence of TiO2 microflowers capable of supporting the enhanced loading of organic contaminants onto the film surface. Electrochemical tests in saline solution have revealed that bilayer films provide cathodic protection for the steel substrate. The Al–Zr/TiO2 bilayer presents a lower corrosion current density of 4.01 × 10−7 A/cm2 and a corrosion potential of −0.61 V vs. Ag/AgCl, offering good protection through the preferential oxidation of the bilayer and an increased pitting resistance. The proposed functionalized coating combining anticorrosion and photocatalytic properties is a promising candidate for an anti-fouling system in sea water.
Principles and Challenges for Multi-Stakeholder Development of Focused, Tiered, and Triggered, Adaptive Monitoring Programs for Aquatic Environments
Authors: Munkittrick Kelly R. , Arciszewski Tim J. , Gray Michelle A.
Published: September 2019

In Canada, there is almost 30 years of experience in developing tiered and triggered adaptive monitoring programs focused on looking at whether environmental concerns remain when pulp and paper mills, or metal mines, are in compliance with their discharge limits. These environmental effects monitoring programs were based on nationally standardized designs. Many of the programs have been developed through multi-stakeholder working groups, and the evolution of the program faced repeated frictions and differing opinions on how to design environmental monitoring programs. This paper describes key guidance to work through the initial steps in program design, and includes scientific advice based on lessons learned from the development of the Canadian aquatic environmental effects monitoring program.
Even When No One Is Looking: Students’ Perceptions of Social Work Professions. A Case Study in a Northern Ireland University
Authors: MacDermott Denise
Published: September 2019

Public perceptions, increased scrutiny and successive governments’ reshaping and attempting to define what is and what is not social work has eroded the progressive and radical force of the profession. This article explores how students’ perceive the profession and presents evidence from a small-scale study conducted in a Northern Ireland University with 37 undergraduate social work students and 25 postgraduate student social workers (training-as-practice educators) on their perceptions of the characteristics of a professional social worker. A quantitative research design was used, consisting of a face-to-face survey distributed to respondents following an input on the Place Model, (Clarke, 2016). Respondents also shared their perceptions in relation to Freidson’s (2001) three logics: professionalism, bureaucracy and the free market, with Ternary graphs and word clouds used as a novel way to present this data. Several themes emerged as important characteristics of social work professionals including reliability, accountability, ethics and appearance. At the other end of the scale, respondents identified unprofessional, de-personalised and cynical as the least aspirational qualities of the profession.
Identification of Noise, Vibration and Harshness Behavior of Wind Turbine Drivetrain under Different Operating Conditions
Authors: Gioia Nicoletta , Peeters Cédric , Guillaume Patrick , Helsen Jan
Published: September 2019

Noise, vibration and harshness (NVH) problems are critical issues to be tackled for wind turbine drivetrains. Tracking the behavior of modal parameters of the machines’ fundamental modes during operation it is of high interest to validate complex simulation models. A powerful approach for this purpose is represented by operational modal analysis (OMA). This paper describes the investigation of an automated technique for continuously tracking the modes of a rotating mechanical system running in normal operating conditions. The modal estimation procedure is based on an automatic version of the pLSCF (poly-reference Least-Square Complex Frequency-Domain) algorithm. The latter is coupled with a method that automatically tracks the modal parameters along different data sets. The use of OMA on a rotating component of the wind turbine creates the need to deal with harmonics in order to satisfy one of the assumptions of OMA. For this purpose, the use of a cepstrum editing procedure is analyzed and implemented. Modal estimates obtained from an automated analysis on stand still data and normal operating conditions data are compared, to test the added value of the cepstrum editing procedure and the robustness of the method when used on real data. To illustrate and validate the implemented methodology, data acquired during a long-term monitoring campaign of a wind turbine drivetrain are used.
Using Q Methodology to Explore Risk Perception and Public Concern about Tree Pests and Diseases: The Case of Ash Dieback
Authors: Urquhart Julie , Potter Clive , Barnett Julie , Fellenor John , Mumford John , Quine Christopher P.
Published: September 2019

This paper seeks to address the need for a more nuanced understanding of public perceptions of risk-related events by investigating the nature of and drivers for a ‘concerned public’ to an environmental issue, using the case study of the ash dieback outbreak in the UK. Q Methodology, an approach that combines both quantitative and qualitative data through factor analysis to identify different ways of thinking about a particular issue, was used to investigate the subjective response of local publics to ash dieback in East Kent, England, one of the early outbreak locations. Five narratives are identified, distinguishing perceptions of risk and management preferences: (1) call for better biosecurity; (2) resilient nature and techno-scientific solutions; (3) fatalistic; (4) disinterested; and (5) pro-active citizens. Four narratives demonstrated concern about the impacts of ash dieback on woodland ecosystems, but beliefs about whether the disease arrived in the UK on infected imported nursery stock or on windblown spores varied. The results of this study contribute to improving understanding of the drivers of differing public perceptions of tree health risks, an important consideration for designing socially acceptable strategies for managing tree pests and diseases, and other environmental risks, in the future.
The Effect of Pine Forest Structure on Bird-Mobbing Behavior: From Individual Response to Community Composition
Authors: Dagan Uzi , Izhaki Ido
Published: September 2019

Pine-forest bird communities are affected by the forest structure and the density and composition of its understory vegetation. In this study, we focused on the combined effects of vegetation structure and caller identity on the mobbing behavior of birds in breeding and non-breeding seasons. We examined the effect of the understory structure and the density of three types of conifer forest habitats on bird behavior by broadcasting three different types of mobbing calls: Those of two all-year resident species in the state Israel (Sardinian warbler Sylvia melanocephala Gmelin and great tit Parus major L.) and one European species (coal tit Periparus ater L.), which is absent from these habitats. The mobbing call attracted 689 birds of 17 species, which represented 31% to 95% of the forest bird species that we detected in point counts at the same study plots. Bird reactions to mobbing calls were affected by the status and season, depending on forest type. Our results show that responses were stronger in forests with developed understory in comparison to forests with no understory, especially in winter. The highest number of responders and highest species richness of responders were observed in winter. P. major calls generated more interspecific than intraspecific responses, whereas S. melanocephala calls generated equal levels of inter- and intraspecific reactions. Both species generated different response patterns across the three forest habitat types. The response level of responders is higher when the mobbing calls are issued by local species rather than the P. ater. In winter, the response of non-resident species was higher than of resident species. Based on these results, we encourage the managers to maintain well-established understory vegetation, with special attention to the shrubs layer, to promote species diversity and rich behavioral responses of birds in the conifer forests in the eastern Mediterranean region.
Shallow Shear-Wave Velocity Beneath Jakarta, Indonesia Revealed by Body-Wave Polarization Analysis
Authors: Ry Rexha Verdhora , Cummins Phil , Widiyantoro Sri
Published: September 2019

Noting the importance of evaluating near-surface geology in earthquake risk assessment, we explored the application to the Jakarta Basin of a relatively new and simple technique to map shallow seismic structure using body-wave polarization. The polarization directions of P-waves are sensitive to shear-wave velocities (Vs), while those of S-waves are sensitive to both body-wave velocities. Two dense, temporary broadband seismic networks covering Jakarta city and its vicinity were operated for several months, firstly, from October 2013 to February 2014 consisting of 96 stations, and secondly, between April and October 2018 consisting of 143 stations. By applying the polarization technique to earthquake signals recorded during these deployments, the apparent half-space shear-wave velocity (Vsahs) beneath each station is obtained, providing spatially dense coverage of the sedimentary deposits and the edge of the basin. The results showed that spatial variations in Vsahs obtained from polarization analysis are compatible with previous studies, and appear to reflect the average Vs of the top 150 m. The low Vs that characterizes sedimentary deposits dominates most of the area of Jakarta, and mainly reaches the outer part of its administrative margin to the southwest, more than 10 km away. Further study is required to obtain a complete geometry of the Jakarta Basin. In agreement with previous studies, we found that the polarization technique was indeed a simple and effective method for estimating near-surface Vs that can be implemented at very low-cost wherever three-component seismometers are operated, and it provides an alternative to the use of borehole and active source surveys for such measurements. However, we also found that for deep basins such as Jakarta, care must be taken in choosing window lengths to avoid contamination of basement converted phases.
Nanotechnology in Roman Opaque Red Glass from the 2nd Century AD. Archaeometric Investigation in Red Sectilia from the Decoration of the Lucius Verus Villa in Rome
Authors: Bandiera Mario , Lehuédé Patrice , Verità Marco , Alves Luis , Biron Isabelle , Vilarigues Marcia
Published: September 2019

This work aims to characterise the chemical composition of Roman opaque red glass sectilia dated to the 2nd century A.D and to shed light on Roman glassmaking production of different shades of red, from red to reddish-brown. Due to the lack of technical historical sources for this period many questions about technological aspects still remain. In this project a multi-disciplinary approach is in progress to investigate the red glass sectilia with several red hues from the Imperial Villa of Lucius Verus (161–169 A.D.) in Rome. First, colorimetric measurements were taken to identify the various red hues. The second step was chemical characterization of the samples and the identification of crystalline colouring phases. Particle Induced X-Ray Emission (PIXE) analysis was used to investigate the chemical composition of these glass samples, while the crystalline phases were identified by Raman Spectroscopy and Scanning Electrons Microscope with Energy Dispersive X-ray Spectrometry (SEM-EDS). Using SEM-EDS nanoparticles were detected as a colouring agent, the chemical composition and the morphology of which has been studied in depth. This information has been compared with the colorimetric analysis to establish any correlation with the different colour hues.
The Reliability and Validity of the Telephone-Based and Online Polish eHealth Literacy Scale Based on Two Nationally Representative Samples
Authors: Duplaga Mariusz , Sobecka Karolina , Wójcik Sylwia
Published: September 2019

Adequate ehealth literacy is one of the key instruments safeguarding people against unreliable health-related information obtained from the Internet. This paper presents an assessment of the reliability and the validity of a Polish version of the ehealth literacy scale (Pl-eHEALS). The assessment was carried out on the basis of two nationally representative samples of the Polish population. In the first survey of adults at least 50 years old, the technique of computer-assisted telephone interviewing (CATI) was applied. In the second survey of young adult women (18–35 years old), the technique of computer-assisted web interviewing (CAWI) was used. The reliability and the validity of the Pl-eHEALS was analyzed. There were no floor or ceiling effects revealed in either sample. The Cronbach’s alpha coefficients were 0.90 and 0.88, and Guttman split-half coefficients were 0.89 and 0.81, respectively. Exploratory factors analysis revealed single factor models in both cases. The sum of squared loadings in the first survey was 6.090 and accounted for 58.72% of the variance. In the second survey, the sum was 5.927 and was responsible for 55.06% of the variance. Hypothesis testing showed that, for older adults, higher ehealth literacy was prevalent in the respondents who used the Internet more frequently. Among young adult women, higher readiness to use the Internet as a primary source of health-related information and to undertake specific internet health-related activities was associated with higher ehealth literacy. The analysis reported in this paper confirmed the reliability and the validity of the instrument. It should be stressed that, prior to this study, there was no validated Polish version of the eHEALS that could be used with Polish-speaking respondents.