bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers
Authors: Dhakal Aastha , Upadhyay Rituraj , Wheeler Caroline , Hoyd Rebecca , Karivedu Vidhya , Gamez Mauricio E. , Valentin Sasha , Vanputten Meade , Bhateja Priyanka , Bonomi Marcelo , Konieczkowski David J. , Baliga Sujith , Mitchell Darrion L. , Grecula John C. , Blakaj Dukagjin M. , Denko Nicholas C. , Jhawar Sachin R. , Spakowicz Daniel
Published: December 2022

Purpose/Objective(s): Microbiome has been shown to affect tumorigenesis by promoting inflammation. However, the association between the upper aerodigestive microbiome and head and neck squamous cell carcinoma (HNSCC) is not well established. Hypoxia is a modifiable factor associated with poor radiation response. Our study analyzed the HNSCC tumor samples from The Cancer Genome Atlas (TCGA) to investigate the relationship between different HNSCC tumor subsites, hypoxia, and local tumor microbiome composition. Results: A total of 357 patients were included [Oral cavity (OC) = 226, Oropharynx (OPx) = 53, and Larynx/Hypopharynx (LHPx) = 78], of which 12.8%, 71.7%, and 10.3%, respectively, were HPV positive. The mean (SD) hypoxia scores were 30.18 (11.10), 24.31 (14.13), and 29.53 (12.61) in OC, OPx, and LHPx tumors, respectively, with higher values indicating greater hypoxia. The hypoxia score was significantly higher for OC tumors compared to OPx (p = 0.044) and LHPx (p = 0.002). There was no significant correlation between hypoxia and HPV status. Pseudomonas sp. in OC, Actinomyces sp. and Sulfurimonas sp. in OPx, and Filifactor, Pseudomonas and Actinomyces sp. in LHPx had the strongest association with the hypoxia score. Materials/Methods: Tumor RNAseq samples from TCGA were processed, and the R package “tmesig” was used to calculate gene expression signature, including the Buffa hypoxia (BH) score, a validated hypoxia signature using 52 hypoxia-regulated genes. Microbe relative abundances were modeled with primary tumor location and a high vs. low tertile BH score applying a gamma-distributed generalized linear regression using the “stats” package in R, with adjusted p-value < 0.05 considered significant. Conclusions: In our study, oral cavity tumors were found to be more hypoxic compared to other head and neck subsites, which could potentially contribute to their radiation resistance. For each subsite, distinct microbial populations were over-represented in hypoxic tumors in a subsite-specific manner. Further studies focusing on an association between microbiome, hypoxia, and patient outcomes are warranted.
Conductive Mediators in Oxidation Based on Ferrocene Functionalized Phosphonium Ionic Liquids
Authors: Ermolaev Vadim V. , Kadyrgulova Liliya R. , Khrizanforov Mikhail N. , Gerasimova Tatiana P. , Baembitova Gulnaz R. , Lazareva Anna A. , Miluykov Vasili A.
Published: December 2022

Herein, the synthesis of ferrocene-containing salts is presented. Acylation of ferrocene (Fc) according to the Friedel–Crafts method led to ω-bromoacyl ferrocenes. The ω-bromoacyl ferrocenes were subsequently introduced to quaternization reaction with tri-tert-butyl phosphine, which resulted in phosphonium salts. Obtained phosphonium salts were characterized by physical methods. The electrochemical properties of phosphonium salts were studied by cyclic voltammetry (CV). It was found that the replacement of n-butyl fragments at the phosphorus atom by tert-butyl leads to a more anodic potential shift. In contrast to isolobal structures Fc-C(O)(CH2)nP+(n-Bu)3X− and Fc-(CH2)n+1P+(n-Bu)3X−, the CV curves of Fc-C(O)(CH2)nP+(t-Bu)3X− and Fc-(CH2)n+1P+(t-Bu)3X− did not show a large discrepancy between forward and reverse currents. The transformation of the C=O groups to CH2 fragments had a significant effect on the electrochemical properties of ferrocene salts, the oxidation potential of which is close to that of pure ferrocene.
Immunomodulation of HDAC Inhibitor Entinostat Potentiates the Anticancer Effects of Radiation and PD-1 Blockade in the Murine Lewis Lung Carcinoma Model
Authors: Kim Yeeun , Park Kyunghee , Kim Yeon Jeong , Shin Sung-Won , Kim Yeon Joo , Choi Changhoon , Noh Jae Myoung
Published: December 2022

Although the combination of radiotherapy and immunotherapy has proven to be effective in lung cancer treatment, it may not be sufficient to fully activate the antitumor immune response. Here, we investigated whether entinostat, a histone deacetylase inhibitor, could improve the efficacy of radiotherapy and anti-PD-1 in a murine syngeneic LL/2 tumor model. A total of 12 Gy of X-rays administered in two fractions significantly delayed tumor growth in mice, which was further enhanced by oral entinostat administration. Flow cytometry-aided immune cell profiling revealed that entinostat increased radiation-induced infiltration of myeloid-derived suppressor cells and CD8+ T cells with decreased regulatory T-cells (Tregs). Transcriptomics-based immune phenotype prediction showed that entinostat potentiated radiation-activated pathways, such as JAK/STAT3/interferon-gamma (IFN-γ) and PD-1/PD-L1 signaling. Entinostat augmented the antitumor efficacy of radiation and anti-PD-1, which may be related to an increase in IFN-γ-producing CD8+ T-cells with a decrease in Treg cells. Comparative transcriptomic profiling predicted that entinostat increased the number of dendritic cells, B cells, and T cells in tumors treated with radiation and anti-PD-1 by inducing MHC-II genes. In conclusion, our findings provided insights into how entinostat improves the efficacy of ionizing radiation plus anti-PD-1 therapy and offered clues for developing new strategies for clinical trials.
A State of the Art Review of Fillet Welded Joints
Authors: Chandramohan Dinesh Lakshmanan , Roy Krishanu , Taheri Hafez , Karpenko Michail , Fang Zhiyuan , Lim James B. P.
Published: December 2022

Fillet welded joints are commonly used in steel structures for various engineering applications such as buildings, bridges, railways, ships, and marine structures. Fillet welded joints are generally subjected to static and fatigue loading, resulting in failures of such welded joints. A number of experimental and numerical investigations on the strength and failure behaviour of fillet welded joints have been published. This paper presents a comprehensive review of research results on the static strength, fatigue life, and thermal performance of fillet welded joints. The review covers the various influential factors, such as loading direction, weld geometry, grades of steel, filler materials, welding process, weld penetration, strength mismatch of weld metal, and post-welded treatment. In total, 100 papers were critically reviewed, which were published from 1970 till date. The key findings and research developments on fillet welded joints are summarised. It was found that the transverse fillet welded joints have a higher static strength than the longitudinal fillet welded joints. Filler materials, post-welded treatment, and penetration of weld metal can offer significant strength enhancements in terms of their static and fatigue strength. Lastly, research gaps have been found in the existing body of knowledge, which will help guide future research.
Effect of an Adaptive-Density Filling Structure on the Mechanical Properties of FDM Parts with a Variable Cross-Section
Authors: Liu Jian , Su Zhou , Wang Chenyue , Xu Zhuofei
Published: December 2022

Fused deposition modeling (FDM) technique is one of the most popular additive manufacturing techniques. Infill density is a critical factor influencing the mechanical properties of 3D-printed components using the FDM technique. For irregular components with variable cross-sections, to increase their overall mechanical properties while maintaining a lightweight, it is necessary to enhance the local infill density of the thin part while decreasing the infill density of the thick part. However, most current slicing software can only generate a uniform infill throughout one model to be printed and cannot adaptively create a filling structure with a varying infill density according to the dimensional variation of the cross-section. In the present study, to improve the mechanical properties of irregular components with variable cross-sections, an adaptive-density filling structure was proposed, in which Hilbert curve with the same order was used to fill each slice, i.e., the level of the Hilbert curves in each slice is the same, but the side length of the Hilbert curve decreases with the decreasing size of each slice; hence, the infill density of the smaller cross-section is greater than that of the larger cross-section. The ultimate bearing capacity of printed specimens with the adaptive-density filling structure was evaluated by quasi-static compression, three-point bending, and dynamic compression tests, and the printed specimens with uniform filling structure and the same overall infill density were tested for comparison. The results show that the maximum flexural load, the ultimate compression load, and the maximum impact resistance of the printed specimens with the adaptive-density filling structure were increased by 140%, 47%, and 82%, respectively, compared with their counterparts using the uniform filling structure.
Interpretation and Transformation of Intrinsic Camera Parameters Used in Photogrammetry and Computer Vision
Authors: Lin Kuan-Ying , Tseng Yi-Hsing , Chiang Kai-Wei
Published: December 2022

The precision modelling of intrinsic camera geometry is a common issue in the fields of photogrammetry (PH) and computer vision (CV). However, in both fields, intrinsic camera geometry has been modelled differently, which has led researchers to adopt different definitions of intrinsic camera parameters (ICPs), including focal length, principal point, radial distortion, decentring distortion, affinity and shear. These ICPs are indispensable for vision-based measurements. These differences can confuse researchers from one field when using ICPs obtained from a camera calibration software package developed in another field. This paper clarifies the ICP definitions used in each field and proposes an ICP transformation algorithm. The originality of this study lies in its use of least-squares adjustment, applying the image points involving ICPs defined in PH and CV image frames to convert a complete set of ICPs. This ICP transformation method is more rigorous than the simplified formulas used in conventional methods. Selecting suitable image points can increase the accuracy of the generated adjustment model. In addition, the proposed ICP transformation method enables users to apply mixed software in the fields of PH and CV. To validate the transformation algorithm, two cameras with different view angles were calibrated using typical camera calibration software packages applied in each field to obtain ICPs. Experimental results demonstrate that our proposed transformation algorithm can be used to convert ICPs derived from different software packages. Both the PH-to-CV and CV-to-PH transformation processes were executed using complete mathematical camera models. We also compared the rectified images and distortion plots generated using different ICPs. Furthermore, by comparing our method with the state of art method, we confirm the performance improvement of ICP conversions between PH and CV models.
Automated Detection of Substance-Use Status and Related Information from Clinical Text
Authors: Alzubi Raid , Alzoubi Hadeel , Katsigiannis Stamos , West Daune , Ramzan Naeem
Published: December 2022

This study aims to develop and evaluate an automated system for extracting information related to patient substance use (smoking, alcohol, and drugs) from unstructured clinical text (medical discharge records). The authors propose a four-stage system for the extraction of the substance-use status and related attributes (type, frequency, amount, quit-time, and period). The first stage uses a keyword search technique to detect sentences related to substance use and to exclude unrelated records. In the second stage, an extension of the NegEx negation detection algorithm is developed and employed for detecting the negated records. The third stage involves identifying the temporal status of the substance use by applying windowing and chunking methodologies. Finally, in the fourth stage, regular expressions, syntactic patterns, and keyword search techniques are used in order to extract the substance-use attributes. The proposed system achieves an F1-score of up to 0.99 for identifying substance-use-related records, 0.98 for detecting the negation status, and 0.94 for identifying temporal status. Moreover, F1-scores of up to 0.98, 0.98, 1.00, 0.92, and 0.98 are achieved for the extraction of the amount, frequency, type, quit-time, and period attributes, respectively. Natural Language Processing (NLP) and rule-based techniques are employed efficiently for extracting substance-use status and attributes, with the proposed system being able to detect substance-use status and attributes over both sentence-level and document-level data. Results show that the proposed system outperforms the compared state-of-the-art substance-use identification system on an unseen dataset, demonstrating its generalisability.
Evolution of vibration disease terminological concepts and issues of causal relationship assessment between disease and occupation and professional suitability
Authors:   FSBEI HE Samara State Medical University of the Ministry of Health of the Russia Federation, Babanov S. A. , Azovskova T. A. ,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russia Federation, Kiryushina T. M. ,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russia Federation, Agarkova A. S. ,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russia Federation, Bezshanova A. E. ,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russia Federation
Published: December 2022

The article analyzes the pathological changes in the human body caused by the impact of vibration. Each variant of the vibration disease is distinguished by the corresponding clinical manifestations depending on the etiological factor. The evolution of terminological concepts in vibration disease and the issues of causal relationship assessment between disease and occupation and professional suitability are presented.
Laboratory diagnostics of helminthiases and parasitosis
Authors:   Infectious Diseases Hospital in Geok Tepe, Ahal Region, Turkmenistan, Yusupova G. K.
Published: December 2022

The main role in the diagnosis of helminthiases and parasitosis is played by laboratory tests. Taking into account the fact that the same person may have a combination of several helminthiases and parasitosis, it is recommended to perform several tests at once or a comprehensive analysis for common helminthiasis and parasitosis, which is more convenient for the doctor and the patient.
Working conditions and their hygienic assessment in multidisciplinary medical organizations
Authors:   FSBEI HE Samara State Medical University of the Ministry of Health of the Russia, Tupikova D. S.
Published: December 2022

At present, one of the main tasks of the state and society is preservation and strengthening of the health of the able-bodied population. Employees of medical organizations are exposed to the combined effects of a significant number of harmful production and professional factors. In particular, the factors of the working environment include biological, chemical, and physical factors, while those of the labor process involve tension and severity. Therefore, the study of working conditions of medical personnel is a priority in occupational health. The purpose of the study is to analyze the working conditions of employees of medical organizations and iden tify priority production-related and occupational pathologies arising from the impact of unfavorable production and occupational factors in order to develop preventive measures. Materials and methods. The object of the study was 1,443 reports of the special assessment of working conditions. We carried out our own studies of the parameters of the microclimate and lighting in the premises: the number of measurements was 5,398, measurements were carried out in 60 premises of medical organizations, and 727 air samples were taken to determine the microbial load. Results. According to the studies of the conditions and nature of work at the workplaces of medical workers in the examined medical organizations and according to the results of a special assessment of working conditions and our own research, the conditions corresponded to a harmful class of 1–3 degrees and of the 4th degree for workers of the oncological hospital. The level of maximum microbial load in the doctors' lounges and nursing rooms increased by the middle of the work shift and remained high until the end of the working day. Since the air movement speed in the studied rooms was very low, this criterion may be a risk factor for aggravation of the course of general somatic pathologies and, as a result, the development of work-related morbidity in medical workers. It can also be noted that fungi were found in 100 % of samples, with their number decreasing by the end of the work shift, while the number of the genus Staphylococcus representatives, on the contrary, tended to increase by the end of the working day. Conclusion. According to the results of the special assessment of working conditions, the conditions and nature of the labor of medical workers in the studied medical organizations corresponded to the harmful class of 1–4 degrees. The 4th degree of the 3rd class of working conditions was due to the personnel’s work with cytostatic drugs. Microclimatic parameters corresponded to hygienic standards (at low air speeds). Fungi and representatives of the genus Staphylococcus were found in 100 % of air samples. A detailed study of the species identification of micromycetes in the indoor air showed that the number of Penicillium and Aspergillus micromycetes significantly exceeded the number of other species.
Professor V. A. Danilin. Biography milestones (to the 50th anniversary of the Department of Occupational Diseases and Clinical Pharmacology, Samara State Medical University)
Authors:   FSBEI HE Samara State Medical University of the Ministry of Health of Russia, S. A. Babanov S. A. Babanov
Published: December 2022

The article describes the main milestones of the biography of professor V. A. Danilin, PhD in Medicine.
Recurrence of rare disease after kidney transplant
Authors: Farnood Farahnoosh , Hejazian Seyyedeh Mina , Boostani Kamal , Mardomi Alireza , Ardalan Mohammadreza
Published: December 2022

The incidence of chronic kidney diseases (CKDs) by rare etiologies is growing along with other CKDs. This mini-review discusses the epidemiology, pathogenesis, clinical presentation, and diagnosis of rare kidney disease recurrence after kidney transplantation (KTx) including primary hyperoxaluria (PH), adenine phosphoribosyl transferase (APRT), C3 glomerulopathy (C3 GP), and fibrillary glomerulonephritis (FGN). It was shown that PH, like acute rejection, causes delayed graft function, confusing the physicians. Moreover, C3 GP is more prevalent than FGN among kidney transplant patients. Therefore, it is necessary to monitor rare diseases (RDs) before KTx in patients with any history of bilateral nephrocalcinosis or nephrolithiasis.
The effect of oral zinc sulfate on prevention of chemotherapy-induced oral mucositis in breast cancer patients treated with adriamycin and cyclophosphamide; a double-blind randomized clinical trial
Authors: Roayaei Mahnaz , Andalib Zeynab , Akhavan Ali
Published: December 2022

Introduction: One of the most important complications faced by cancer patients is chemotherapy-induced oral mucositis (CIOM). In addition, the role of orally used zinc sulfate in its prevention and treatment is still a controversial issue and the results in this regard have not been conclusive. Objectives: Evaluation the effect of zinc sulfate supplement on prevention of CIOM in breast cancer patients treated with adriamycin and cyclophosphamide was the aim of this study. Patients and Methods: The current double-blind randomized clinical trial was conducted on 87 patients with breast cancer. Consumption of two oral zinc sulfate tablets and two placebo tablets with food was prescribed in the case (44 patients) and control (43 patients) groups, respectively. During the 4 cycles of chemotherapy, the incidence and severity of CIOM, the onset time of mucositis from the start of chemotherapy, the severity of pain, and the severity of dry mouth were recorded. In addition, the patients’ quality of life was recorded using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Results: Findings revealed that the severity of CIOM in the first, second, and third sessions with the values of 1.22±1.01, 1.18±0.97 and 1.02±0.79, respectively, was significantly lower in the case group than the control group with the values of 1.91±0.89, 1.80±0.92, and 1.67±0.85, respectively (P<0.05). In addition, the severity of pain and dry mouth in the first and second sessions of chemotherapy was significantly lower in the case group (P<0.05). However, no significant difference was observed between the two groups in quality of life (P>0.05). Conclusion: Oral zinc sulfate had a significant role in reduction of the incidence and severity of CIOM, the severity of dry mouth, and the severity of pain in the initial sessions of chemotherapy. However, no significant difference was in postponing the incidence of CIOM and the quality of life of patients in the case group. Trial Registration: This trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20150304021338N2; https://irct.ir/trial/51105, ethical code# IR.MUI.MED. REC.1399.277).
Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge
Authors: Tolouian Ramin , Tolouian Audrey , Dastan Farzaneh , Farhangi Vida , Peymani Payam , Saeifar Sanam , Montes Oscar Felipe Borja , Mohmoodnia Leila , Khosravifarsani Mohammadreza , Sadighpour Tella
Published: December 2022

Cisplatin is a first-line antitumor drug which is applied in the therapeutic field of numerous kinds of cancers. The main dose-dependent adverse effect of cisplatin is nephrotoxicity in approximately one-third of patients, who received this drug during their treatment. Oxidative stress is one of the most significant mechanisms in cisplatin nephrotoxicity. Cisplatin-induced oxidative stress stimulates apoptosis, inflammation, mitochondrial damage within cells, and endoplasmic reticulum (ER) stress. The administration of an antioxidant in this context could be a suitable approach for preventing of cisplatin nephrotoxicity. Antioxidants are categorized into four classes: dietary antioxidants, free radical scavengers, thiol-containing compounds, and iron chelators.
Systemic lupus erythematosus following SARS-CoV-2 vaccination; a review of literature
Authors: Mahmoudnia Leila , Roshan Bijan , Jahantigh Hamid Reza , Mojtahedi Zahra , Montes Oscar F Borja , Sadighpour Tella , Khosravifarsani Mohammadreza
Published: December 2022

From March 2020, the coronavirus disease 2019 (COVID-19) pandemic challenged public health and healthcare systems worldwide. Viral infection is one of the environmental factors that has been associated with the development, relapse, or exacerbation of systemic lupus erythematosus (SLE). SLE patients are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of immune system dysfunction related to their disease as well as immunosuppression medications. So far, the most effective way to reduce SARS-CoV-2 infection-induced hospitalization and death is vaccination. On the other hand, SLE patients present distinct challenges related to the safety and effectiveness of SARS-CoV-2 vaccination. We have reviewed some reports on the onset or flare of SLE post-COVID-19 vaccination. Of note, the mRNA COVID-19 vaccines are associated with increased SLE disease activity, more frequently than the other types of COVID-19 vaccines.
Syntheses and Antioxidant Activity of 1-Isonicotinoyl-4-phenylthiosemicarbazide and Crystal Structures of N-Phenyl-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amine Hydrochloride and 4-Phenyl-3-(pyridin-4-yl)-1H-1,2,4-triazole-5(4H)-thione derived from 1 Isonicotinoyl-4-phenylthiosemicarbazide
Authors: Faye Ndama , Mbow Bédié , Gaye Aïssatou Alioune , Ndoye Cheikh , Diop Mayoro , Excoffier Grégory , Gaye Mohamed
Published: December 2022

The title compound C13H12N4OS (I) is synthetized from isonicotinic hydrazide and isothiocynate. Compounds C13H11N4OCl (II) and C13H10N4S (III) where obtained upon reaction of (I) with Fe(II) or Mn(II) salts. Compound (II) is heterocyclic 1,3,4-oxadiazole while compound (III) is heterocyclic 1,2,4-triazole. The 1,3,4-oxadiazol derivative is almost planar with dihedral angle of 2.66 (8) and 5.14 (8)° between 1,3,4-oxadiazole ring and phenyl and pyridinium rings respectively; the dihedral angle between the phenyl and pyridinium rings is 3.92 (8)°. The 1,2,4-triazole derivative is non-planar. The phenyl and pyridyl rings form dihedral angles of 58.35 (5) and 58.33 (5)°, respectively, with the 1,2,4-triazole ring; the dihedral angle between the phenyl and pyridyl rings is 36.85 (4)°. In the compound (II) intramolecular hydrogen bonds of type N—H···Cl, C—H···N and C—H···Cl resulting in S(6) ring stabilize the structure. Intermolecular hydrogen bonds of type N—H···N, C—H···N, C—4···Cl link the molecule thus forming a three-dimensional network. In the structure of compound (III), intermolecular hydrogen bonds of type N—H···N, C—H···N, C—H···S1,link the monomer in a three-dimensional network.
Irkutsk institute of chemistry named after A.E. Favorskii SB RAS – achievements in the field of pharmaceutical research
Authors:   SSC RF State Research Institute chemistry and technology of organoelement compounds, Storozhenko P.A. , Rybakov Y. L. ,   State Center for Expertise in the Field of Scientific Research Institute – Federal Research Centre for Projects Evaluation and Consulting Services, Gukasov V.M. ,   Scientific Research Institute FRCEC, Myakinkova L.L. ,   cientific Research Institute – Federal Research Centre for Projects Evaluation and Consulting Services, Kuznetsov I.A. ,   Astrakhan State University of Architecture and Civil Engineering, Bekmetova M.Kh. ,   Astrakhan State Technical University, Zhigacheva I.V. ,   Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Rasulov M.M. ,   Astrakhan State Technical University
Published: December 2022

The data showing on an example only of one scientific school potential of a domestic chemic-pharmaceutical science are resulted. It is marked. Presence of two mainstreams — creation of original domestic preparations and food additives, and also development of medicines-generics taking place in Irkutsk institute of chemistry of the Russian Academy of Science. Affirms, that development of these most perspective directions keeps on enthusiasm devoted to the business and school experts of the highest class. It is recommended to integrate efforts of all experts within the limits of RAS.
Some aspects of smart prosthesis safety for transradial amputees taking into account the use of Bluetooth technology
Authors:   Mechanical Engineering Research Institute of the Russian Academy of Sciences, Sergeev A.M. , Kovalev N.S.
Published: December 2022

The article describes some safety aspects of Bluetooth technology for upper limb below the elbow joint smart prostheses.
Influence of Trekrezan on psychoemotional state and hemodynamic on young men
Authors:   Astrakhan State Technical University, Rasulov M.M. , Rybakov Y. L. ,   Scientific Research Institute – Federal Research Centre for Projects Evaluation and Consulting Services, Gukasov V.M. ,   Scientific Research Institute FRCEC, Myakinkova L.L. , Kuznetsov I.A. ,   Astrakhan State University of Architecture and Civil Engineering, Begmetova M. Kh. ,   Astrakhan State Technical University, Lakeikina I. A.
Published: December 2022

28 young men aged 18 to 21 were examined. Main group received Trekrezan in a doze of 600 mg/day within 3 months. Trekrezan improved exchange parameters intimate hemodynamic and mental state with hypernension.
Software for bacterial cells scanning probe microscopy
Authors:   Lomonosov Moscow State University, Yaminsky I.V. , Akhmetova A.I. , Maximova N.E.
Published: December 2022

The article discusses high-speed probe microscopy of biological objects and software for processing the results. The study of biological objects using probe microscopy does not require complex sample preparation, but direct selection of the optimal scanning mode requires experience and practical skills.
Actual aspects of creation вasics of the national protection system from new infections
Authors:   Maikop State Technological University, Agirov A.H. , Alekhnovich A.V. ,   Central Military Clinical Hospital named after A.A. Vishnevsky, Gukasov V.M. ,   Scientific Research Institute FRCEC, Zakharov V.A. ,   JSC Research and Production Center Modul, Konyshev I.S. ,   Research Institute of Military Medicine of the Ministry of Defense of the Russian Federation, Tarasov B.V. ,   CJSC SPC «Modul»
Published: December 2022

The threats to biological safety at the present stage are analyzed, the value of the System is assessed. we provide intellectual support for management decisions implemented in the Republic of Adygea in 2014-2018. in countering these threats (project «SIP-RA») and the creation of the basis of the National system of protection against new infections (Decree of the President of the Russian Federation of October 12, 2020, No. 620)
Türkiye İç Sularında Dağılım Gösteren 13 Gobio Türünün Boy-Ağırlık İlişkisi
Authors: ŞENYİĞİT Gökçen , MAZLUM Rahşan Evren
Published: December 2022

Bu çalışma, Türkiye iç sularında dağılım gösteren Gobio türlerinin bazı populasyon parametrelerinin belirlenmesi amacıyla yapılmıştır. Çalışma kapsamında Recep Tayyip Erdoğan Üniversitesi Su Ürünleri Fakültesi Su Ürünleri Müzesi’nde bulunan 13 Gobio türüne ait 468 birey incelenmiştir. Bireylerin toplam boy (TL), çatal boy (FL), standart boy (SL) ve ağırlık (W) ölçümleri yapılmıştır. 13 Gobio türünün boy-ağırlık ve boy-boy ilişkileri incelenmiştir. Boy- ağırlık ilişkilerinin “b” değeri 2,732 (G. insuyanus) ile 3,933 (G. bulgaricus) arasında değişmiştir. Büyümenin G. artvinicus (P
The Relationship of Barn and Animal Hygiene with Milk Yield, Milk Composition and Mastitis in Holstein and Simmental Cows
Authors: ÇELEBİ Ayşe , AKDAĞ Filiz
Published: December 2022

This study was conducted to determine the effect of barn hygiene on animal hygiene in Holstein and Simmental cows and the relationship between animal hygiene and milk yield, milk composition and somatic cell count (SCC). In the study, some hygiene traits of four different barns with 40 heads of Holstein and Simmental cows in the early and middle lactation period, the degree of cleanliness of the upper rear leg, lower rear leg, abdomen, udder and tail head of cows, the milk yield and composition of animals, and the SCC were determined. In the study, it was determined that bedding was more dirtiness in Holstein barns than Simmental barns. In terms of body hygiene, breed and breed X lactation period interaction were determined to be effective (P
Farklı Ses Uyarılarının Sazan Balıklarında (Cyprinus carpio L. 1758) Büyüme Performansı ve Vücut Kompozisyonuna Etkisi
Authors: GENÇER Macit , DOĞANKAYA Levent
Published: December 2022

Bu çalışmada, farklı ses uyarılarının balıklarda büyüme performansına etkilerinin incelenmesi amaçlanmıştır. Bu doğrultuda 240 adet sazan balığı (Cyprinus carpio) ile 3 tekerrürlü 75 günlük bir deney kurulmuştur. Ses dosyaları (klasik müzik, rock müzik, tasavvuf müziği) bilgisayar ile kontrol edilen yönlendirilmiş hoparlör düzenekleri ile gruplara günde 3 kez birer saat süreyle toplam 3 saat uygulanmış ve balıklar günde iki kez ticari akvaryum balığı yemi ile doyuncaya kadar beslenmiştir. Canlı ağırlık artışında gruplar arası istatistiksel fark görülmemiştir (p>0,05). Oransal ağırlık artışı (OAA) ve spesifik büyüme oranı (SBO) bakımından grup değerleri istatistiki olarak önemli farklılık göstermiştir (p0,05). Deneme sonunda en yüksek yaşama oranı (YO) rock müzik dinletilen grupta hesaplanırken diğer iki deneme grubu bunu takip etmiş ve en düşük yaşama oranı değerini Kontrol grubu sergilemiştir. Elde edilen sonuçlar, farklı ses uygulamalarının sazan balıklarında ağırlık kazancı ve yaşama oranı üzerinde olumlu etkisi olabileceğine işaret etmektedir. Bu çalışmada kullanılan sistem ve izlenen prosedür balıklar için fiziksel ya da kimyasal müdahale gerektirmeyen ve çevreci bir büyüme artırıcı olarak potansiyel taşımaktadır.
BLDC MOTOR : MODELING AND OPTIMIZATION SPEED CONTROL USING FIREFLY ALGORITHM
Authors: Anshory Izza , Hadidjaja Dwi , Jakaria Ribangun Bambang
Published: December 2022

BLDC motor applications used in various forms in instrumentation, robotics, household, and transportation. One application of transportation equipment used as a propeller of electric bicycle vehicles. The value of the bicycle vehicle adjusted to the speed set, the amount that has determined. The purpose used in this study is to improve the efficiency of the regulation of BLDC motors on electric bicycles. Indicators of increasing performance are increasingly steady-state errors, and transient response required. The method used in this research is to do mathematical modeling in the form of transfer and optimization function equations. The model used is the model with the structure of the transfer function, while the optimization method used in this study is the Ziegler-Nichols method and firefly algorithm. The firefly algorithm is used in this study to obtain optimal Kp, Ki, and Kd values. The results showed that the firefly algorithm achieved better performance compared to the Ziegler-Nichols method.
Penanaman Nilai Pendidikan Agama Islam Pada Kegiatan Ekstrakurikuler Sdit Al Manar Purwakarta
Authors: Putri Tiara , Yustika Nur Destiyani  , Imam Tabroni
Published: December 2022

Agama Islam merupakan agama yang mengatur segala aspek kehidupan serta memiliki nilai-nilai pendidikan yang tentunya bermanfaat bagi umatnya. Pendidikan agama adalah pendidikan yang memberikan pengetahuan dan membentuk sikap kepribadian dan keterampilan peserta didik dalam mengamalkan ajaran agamannya. Guru memiliki tugas untuk menanamkan nilai-nilai pendidikan agama Islam salah satunya dalam kegiatan ekstrakurikuler. Tujuan dari penelitian ini yaitu untuk mengetahui nilai-nilai pendidikan agama Islam yang ditanamkan kepada peserta didik melalui kegiatan ekstrakurikuler yang ada di sekolah SDIT Al-Manar. Dalam penelitian artikel ini menggunakan metode kualitatif deskrifsi melalui pendekatan dengan wawancara. Hasil penelitian ini, dari data ekstrakurikuler yang ada di sekolah SDIT Al-Manar terdapat nilai-nilai pendidikan agama Islam yang ditanamkan kepada peserta didik, yaitu melatih mental spiritual/keruhanian, membentuk sikap pemberani, percaya diri, tanggung jawab, rendah hati, pantang menyerah, disiplin, sabar, jujur, bersikap iffah dan lain-lain. Nilai-nilai pendidikan agama Islam tersebut sangat penting dan tentunya bermanfaat untuk peserta didik
Penanganan Problematika Menghafal Al-Qur’an Bagi Santri Di Pondok Pesantren Baitul Quran Cirata
Authors: Nurtsany Raihan , Putra Raihan Nur Alam  , Linda Hodijah  , Imam Tabroni
Published: December 2022

Menghafal al-Qur’an adalah proses memelihara, menjaga dan mempertahankan kemurnian al-Qur’an. Allah berfirman Di dalam al-Qur’an surat al-Qamar ayat 17 bahwa sungguh telah aku mudahkan Qur’an  untuk dipelajari dan dihafalkan. Dan pada bagian akhir dari ayat tersebut merupakan pertanyaan yang bermakna perintah. Hal ini menunjukkan bahwa al-Qur’an mudah untuk dihafalkan dan Allah juga menantang hamba-Nya untuk membuktikan statemen tersebut. Hasil penelitian menunjukkan bahwa para santri penghafal Qur’an memiliki beragam problem selama kegiatan menghafal al-Qur’an. Ada 2 Problem yang dibedakan yaitu problem internal (dalam diri) dan problem eksternal (luar diri). Seperti rasa malas, tidak sabar dan putus asa, tidak bisa mengatur waktu dan memanfaatkan waktunya dengan baik, tidak mampu disiplin pada kegiatan tahfidz, lupa, bermaksiat, ada masalah dengan lingkungan fisik dan sosialnya. Beragam problem yang dihadapi para santri penghafal Qur’an, menuntut santri untuk aktif serta inovatif untuk mencari solusi atas problematika yang mereka dihadapi. Dan usaha-usaha yang mereka lakukan adalah dengan cara berwudlu, ber-mujahaddah, mencari kegiatan yang positif, berkonsultasi dengan para asatidz, orang tua dan teman , membaca buku-buku inspiratif, bersabar dan tetap beristiqamah meski mengalami kendala dalam menghafal, istirahat yang cukup, berusaha memahami dan mengamalkan isi ayat yang sudah dihafal untuk menguatkan hapalan. Dengan begitu para santri menciptakan suasana dan lingkungan yang kondusif dan nyaman untuk mereka menghafal.
Pengaruh Aplikasi Tik Tok Terhadap Akhlak Anak Di Desa Ciherang, Pasawahan
Authors: Husniyah Hasna , Imam Tabroni
Published: December 2022

Akhlak merupakan elemen yang paling utama dalam pendidikan agama islam. Dimana dalam pembahasan akhlak memuat sifat baik dan buruk. Terdapat banyak ayat al-Quran  yang berkaitan dengan akhlak, hal ini menunjukkan bahwa betapa pentingnya penanaman akhlak dalam ajaran Islam.  Kemajuan  teknologi tentunya mempengaruhi seluruh aspek kehidupan manusia terutama akhlak anak. Penggunaan platform digital dan aplikasi-aplikasi digital seperti Tik Tok tentunya dapat mempengaruhi karakteristik atau akhlak anak. Dalam proses pencarian informasi peneliti menggunakan metode;observasi, dan studi literatur dari berbagai sumber seperti ilmiah jurnal dan buku. Kajian ini menganalisis pengaruh aplikasi tik tok terhadap akhlak anak di Desa Ciherang, Pasawahan. Adapun hasilnya, pengaruh penggunaan aplikasi Tik Tok lebih dominan ke arah negatif. Hal ini menjadi perhatian bagi para pendidik, orang tua dan masyarakat kedepannya untuk saling bekerja sama dalam membentuk anak muda yang berakhlak baik
Upaya Menanamkan Pendidikan Karakter Pada Remaja Dengan Kegiatan Keagamaan Di Kp.Tabrik 2
Authors: Rosmiati Mia , Imam Tabroni
Published: December 2022

Remaja adalah masa yang penting dalam pembentukan generasi bagi penerus bangsa dan agama. Masa remaja merupakan masa peralihan dan masa mencari jati diri. Pada masa inilah remaja banyak dipengaruhi oleh beberapa faktor salah satunya faktor lingkungan. Sekarang ini tidak sedikit remaja yang acuh terhadap perintah agama ataupun orang tuanya dalam kegiatan kegaamaan salah satunya dalam kegiatan tadarus al-qur’an. Karena pengaruh dampak negatif dari perkembangan zaman yaitu dengan adanya gadget, banyak para remaja yang mengajak teman sebayanya bermain game. Dampak ini sangat terasa dalam lingkungan masyarakat banyaknya para remaja yang berkumpul bermain game dengan teman-temannya dibandingkan remaja yang berkumpul melakukan kegiatan keagamaan di masjid. Dalam rangka upaya menanamkan pendidikan karatkter kepada remaja dengan kegiatan keagamaan dapat memperdalam serta memperluas pengetahuan keagamaan. Sekaligus memperkuat karakter remaja yang berlandaskan pada nilai serta norma religi yang kokoh. Dengan menanamkan pedidikan karakter pada remaja melalui kegiatan keagamaan ini diharapkan dapat mencegah adanya waktu luang yang dimanfaatkan pada kegiatan tidak bermanfaat.
Management of Scabies Cases with Secondary Infection in Children through Family Medicine Approach
Authors: Luwito Jeffry , Indah Lestari Dewi , Putri Yulius Christabella , Putri Liviansyah Melvira
Published: December 2022

Scabies is a skin infestation caused by Sarcoptes scabiei (var. hominis). The prevalence of scabies in Indonesia is 4.60% - 12.95% and ranks the third most common disease. The Cikupa Public Health Center experienced an increase in the number of new scabies cases as many as 34 new cases in January - June 2022 compared to June - December 2021 as many as 21 new cases. Female patient aged 5 years and 10 months suffered from scabies with secondary infection and had transmitted it to other family members. Problem analysis was carried out by mapping the Mandala of Health with the principles of family medicine and comprehensive management. Ms. K and her family members recovered from scabies and no new lesions appeared. The patient and her families have been given education about scabies and there are no new infections in them so further transmission of scabies can be prevented. The family medicine approach and Mandala of Health have helped Ms. K and her family in the treatment and eradication of scabies.
A Comparative Study on Organizational Satisfaction between State and Private Prison
Authors:   The Correction Welfare Society of Korea, Chun Jung Hwan
Published: December 2022

This study is to empirically determine whether there is a difference accordingly by verifying the effect on satisfaction of national correctional oraganization and private correctional organization. To this end, organizational factors such as sense of mission are used as independent variables in this study and I tested the influencing factors of organizational factors on organizational satisfaction through multiple regression analysis throughout a research model with demographic and sociological characteristics of two oraganization staffs as control variables and organizational satisfaction as dependent variables study result have shown that role conflict had a negative effect on organizational satisfaction in two oraganization that national correctional oraganization value a sense of mission compared to other factors and communication is more important than a sense of mission in private correctional organization. Therefore, considering that this study has limitations in that there are differences in bureaucratic sociological perspectives and representation of samples, I suggested the need for an organizational plan of motivational strategy mission-building and communication activation and production-oriented organizational management plan strategies to minimize role conflict conforming to the characteristics of both organizations, etc as an implication
A Tutorial on Bayesian Latent Class Analysis Using JAGS
Authors: Qiu Meng
Published: December 2022

This tutorial introduces readers to latent class analysis (LCA) as a model-based approach to understand the unobserved heterogeneity in a population. Given the growing popularity of LCA, we aim to equip readers with theoretical fundamentals as well as computational tools. We outline some potential pitfalls of LCA and suggest related solutions. Moreover, we demonstrate how to conduct frequentist and Bayesian LCA in R with real and simulated data. To ease learning, the analysis is broken down into a series of simple steps. Beyond the simple LCA, two extensions including mixed-model LCA and growth curve LCA are provided to aid readers’ transition to more advanced models. The complete R code and data set are provided.
THE PROCESS OF MANAGING INNOVATIVE DEVELOPMENT AS AN OBJECT OF ACCOUNTING AND ANALYSIS
Authors: Zavitii Olha , Belova Iryna
Published: December 2022

Introduction. The basis of the innovative development of production entities is the creation of a unique combination of internal capabilities, taking into account the factors of the external environment. To ensure effective management of the innovative development of enterprises, it is extremely important to create a dynamic accounting and analysis system that reflects the components of internal potential and the determination of external trends. The development of accounting and analytically based management principles for the innovative development of enterprises will create the prerequisites for the stabilization of economic growth. Methods. During the preparation of the article, a systematic research approach was used, which made it possible to assess the state of implementation of the process of managing innovative development in the domestic practice of entrepreneurship; the method of theoretical comparison to improve legislative regulation and areas of accounting and analytical procedures; the method of expert evaluations - in the development of organizational provisions for the implementation of the mechanism of accounting and analytical principles of management of innovative development of enterprises in Ukraine. Results. The article defines the process of managing innovation and development of the enterprise and modern principles of innovative activity and development of the enterprise. Factors affecting the success of innovation implementation were analysed. The study revealed the main problems of the formation of the mechanism of innovation and development of the enterprise, which require a comprehensive solution. Discussion. Further research on the development of the process of managing the innovative development of enterprises will consist in the substantiation of the implementation of modern trends in the formation of an information system based on strategically oriented accounting data and analytical procedures. Keywords: enterprise, innovations, innovative development, management of innovative development, information economy.
MODERN TECHNOLOGIES OF BUSINESS ANALYTICS AS A TOOL FOR IMPROVING THE COMPANY'S BUSINESS COMMUNICATIONS
Authors: Putsenteilo Petro , Dovbush Andrii , Bincharovska Tetiana , Homotiuk Viktoriia
Published: December 2022

Introduction. Modern information and digital solutions qualitatively change all chains of business processes of companies and open wide opportunities for business communications. However, companies need to independently determine their needs in the development and implementation of appropriate information and software solutions, substantiation the reasons for the rational choice of adequate options for analytical procedures from the multitude of digital options currently available. In fact, the problems of choosing directions for the analysis of business indicators are in the general direction of solving the problems of the informational-communicative and organizational-analytical functions of the development of economic entities. Methods. The theoretical and methodological basis of the research is the fundamental provisions of modern economic science, the work of domestic and foreign scientists. The following methods were used in the research process, in particular: analysis and synthesis - to study the object and subject of research; abstract and logical (theoretical generalizations and formulation of conclusions); constructive and experimental (formation of a management decision with the help of analytical support). Results. According to the results of the research, it was found that business analysis integrates technical and economic knowledge, which ensures their applied use, contributes to the acquisition and systematization of information about the company's work at all levels, and establishes logical connections between stakeholders. The connection between business analytics, accounting system, information support and control procedures were revealed. The close relationship between business analytics and business communications as a set of information-analytical relationships determined by the specifics of the activity and different levels of the company's organizational culture, based on the interaction of the system of social and economic, organizational-management and technical-technological relations, is substantiated. Discussion. The results of the study can be used in the formation of a strategy for the development of analytical work and the construction of modern communication links between stakeholders in the process of their interaction. Keywords: information, business analysis, business analytics, business communication, company, accounting, management.