bluuebunny/crossref_metadata_2025 huggingface dataset:
Rate and Timing of Return to Golf After Hip, Knee, or Shoulder Arthroplasty: A Systematic Review and Meta-analysis
Authors: Robinson Patrick G. , Williamson Tom R. , Creighton Andrew P. , Cheng Jennifer , Murray Andrew D. , Prather Heidi , Dines Joshua S. , Gulotta Lawrence V. , Su Edwin P. , Press Joel M. , Hawkes Roger , Clement Nick D.
Published: January 2022

Background:

The physical and mental health benefits of golf are well recognized, and as a moderate-intensity activity, it is an ideal sport for patients after joint arthroplasty.

Purpose:

To assess the rate and timing of returning to golf and the factors associated with these after hip, knee, or shoulder arthroplasty.

Study Design:

Meta-analysis; Level of evidence, 4.

Methods:

A search of PubMed and Medline was performed in March 2021 in line with the 2009 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Search terms included sport, golf, and arthroplasty. The criterion for inclusion was any published research article studying return to golf after arthroplasty. Random-effects modeling was used to measure rates of returning to golf for each type of arthroplasty.

Results:

A total of 23 studies were included for review. All studies were retrospective in their methodology. The mean age of patients was 66.8 years (SD, 3.37). Four studies reported on hip arthroplasty, 6 on knee arthroplasty, and 13 on shoulder arthroplasty. Among 13 studies, the mean rate of returning to golf was 80% (95% CI, 70%-89.9%). Hip, knee, and shoulder arthroplasty had mean return rates of 90% (95% CI, 82%-98%), 70% (95% CI, 39%-100%), and 80% (95% CI, 68%-92%), respectively. Among 9 studies, the mean time to return to golf was 4.4 months (95% CI, 3.2-6). Change in handicap was reported in 8 studies (35%) with a mean change of −0.1 (95% CI, –2.4 to +2.2). There were no studies presenting factors associated with return to golf.

Conclusion:

This is the first meta-analysis of returning to golf after joint arthroplasty. The study reports a high rate of returning to golf, which was greatest after hip arthroplasty. However, the study highlights the paucity of prospective data on demographic, surgical, and golf-specific outcomes after arthroplasty. Future prospective studies are required to eliminate response bias and accurately capture golf and patient-specific outcomes.
Associations Between Canada's Cannabis Legalization and Emergency Department Presentations for Transient Cannabis-Induced Psychosis and Schizophrenia Conditions: Ontario and Alberta, 2015–2019
Authors: Callaghan Russell C. , Sanches Marcos , Murray Robin M. , Konefal Sarah , Maloney-Hall Bridget , Kish Stephen J.
Published: January 2022

Objective

Cannabis legalization in many jurisdictions worldwide has raised concerns that such legislation might increase the burden of transient and persistent psychotic illnesses in society. Our study aimed to address this issue.

Methods

Drawing upon emergency department (ED) presentations aggregated across Alberta and Ontario, Canada records (April 1, 2015–December 31, 2019), we employed Seasonal Autoregressive Integrated Moving Average (SARIMA) models to assess associations between Canada's cannabis legalization (via the Cannabis Act implemented on October 17, 2018) and weekly ED presentation counts of the following ICD-10-CA-defined target series of cannabis-induced psychosis (F12.5; n = 5832) and schizophrenia and related conditions (“schizophrenia”; F20-F29; n = 211,661), as well as two comparison series of amphetamine-induced psychosis (F15.5; n = 10,829) and alcohol-induced psychosis (F10.5; n = 1,884).

Results

ED presentations for cannabis-induced psychosis doubled between April 2015 and December 2019. However, across all four SARIMA models, there was no evidence of significant step-function effects associated with cannabis legalization on post-legalization weekly ED counts of: (1) cannabis-induced psychosis [0.34 (95% CI −4.1; 4.8; P = 0.88)]; (2) schizophrenia [24.34 (95% CI −18.3; 67.0; P = 0.26)]; (3) alcohol-induced psychosis [0.61 (95% CI −0.6; 1.8; P = 0.31); or (4) amphetamine-induced psychosis [1.93 (95% CI −2.8; 6.7; P = 0.43)].

Conclusion

Implementation of Canada's cannabis legalization framework was not associated with evidence of significant changes in cannabis-induced psychosis or schizophrenia ED presentations. Given the potentially idiosyncratic rollout of Canada's cannabis legalization, further research will be required to establish whether study results generalize to other settings.
“The Internal Police Officer Has Not Retired but Has Slowed Down”: Israeli Women Reframe Their Aging Experiences in the Second Half of Life
Authors: Ayalon Liat , Lir Shlomit Aharoni
Published: January 2022

Compared with gains, losses have received a substantial amount of research and public attention. The present study aims to shed light on the positive gains associated with older age from the perspective of older women. Five focus groups with 19 Israeli women over the age of 54 were conducted. Trailers of three different films were used to stimulate discussion about old age and aging and allow for reflections on societal norms in light of personal experiences. Focus group interviews were analyzed thematically. Respondents identified four contexts, characterized by reframing their experiences against societal norms. These included gender stereotypes, physical appearance, interpersonal relations, and employment. This study represents an opening to a different discourse around old age, which is characterized by gains and possibilities brought about by changes in reframing one’s experiences, while distancing oneself and exerting free will vis à vis social norms.
Entertainment Video Games for Academic Learning: A Systematic Review
Authors: Martinez Léa , Gimenes Manuel , Lambert Eric
Published: January 2022

Entertainment video games are very popular among young audiences. Nevertheless, despite their potential to improve cognitive functioning, they are still studied rarely as a tool for digital game-based learning. To better understand video gaming practices’ value in the classroom, this article provides a systematic review of literature on the effect of entertainment video games on academic learning. Our literature search yielded 49 relevant intervention studies published between 2005 and 2019 that integrated entertainment video games into academic curricula from preschool to college. Our review revealed that entertainment video games can be an effective educational tool and are beneficial in almost all academic disciplines, particularly in foreign language and science. However, research on entertainment video gaming’s effects on academic learning is still not extensive enough and remains mostly qualitative. Future studies need to provide a quantitative approach to complete and confirm already-existing literature, particularly in the environmental and social sciences, physical education, and programming. Given entertainment video games’ popularity and benefits on cognition and learning, it seems essential to investigate their practical value further in the education sector and to determine the mechanisms that mediate their effects on academic learning.
Gender-Inclusive Fellowship Naming and Equity, Diversity, and Inclusion in Radiology: An Analysis of Radiology Department Websites in Canada and the United States
Authors: Yan Tyler D. , Mak Lauren E. , Carroll Evelyn F. , Khosa Faisal , Yong-Hing Charlotte J.
Published: January 2022

Purpose: Transgender and gender non-binary (TGNB) individuals face numerous inequalities in healthcare and there is substantial work to be done in fostering TGNB culturally competent care in radiology. A radiology department’s online presence and use of gender-inclusive language are essential in promoting an environment of equity, diversity, and inclusion (EDI). The naming of radiology fellowships and continuing medical education (CME) courses with terminology such as “Women’s Imaging” indicates a lack of inclusivity to TGNB patients and providers, which could result in suboptimal patient care. Methods: We conducted a cross-sectional analysis of all institutions in Canada and the United States (US) offering training in Breast Imaging, Women’s Imaging, or Breast and Body Imaging. Data was collected from each institution’s radiology department website pertaining to fellowship names, EDI involvement, and CME courses. Results: 8 Canadian and 71 US radiology fellowships were identified. 75% of Canadian and 90% of US fellowships had gender-inclusive names. One (12.5%) Canadian and 29 (41%) US institutions had EDI Committees mentioned on their websites. Among institutions publicly displaying CME courses about breast/body or women’s imaging, gender-inclusive names were used in only 1 (25%) of the Canadian CME courses, compared to 81% of the US institutions. Conclusions: Most institutions in Canada and the US have gender-inclusive names for their radiology fellowships pertaining to breast and body imaging. However, there is much opportunity to and arguably the responsibility for institutions in both countries to increase the impact and visibility of their EDI efforts through creation of department-specific committees and CME courses.
Review: The evolution of chemometrics coupled with near infrared spectroscopy for fruit quality evaluation
Authors: Anderson Nicholas T , Walsh Kerry B
Published: January 2022

Short wave near infrared (NIR) spectroscopy operated in a partial or full transmission geometry and a point spectroscopy mode has been increasingly adopted for evaluation of quality of intact fruit, both on-tree and on-packing lines. The evolution in hardware has been paralleled by an evolution in the modelling techniques employed. This review documents the range of spectral pre-treatments and modelling techniques employed for this application. Over the last three decades, there has been a shift from use of multiple linear regression to partial least squares regression. Attention to model robustness across seasons and instruments has driven a shift to machine learning methods such as artificial neural networks and deep learning in recent years, with this shift enabled by the availability of large and diverse training and test sets.
Does Tourism Affect Sustainable Development in MINT Countries?
Authors: Osinubi Tolulope , Adedoyin Ajayi , Olufemi Osinubi , Ajide Folorunsho
Published: January 2022

Following the failure to achieve Millennium Development Goals by most countries in the world, Sustainable Development Goals are now at the center of developmental issues. Consequently, this study aims to examine if tourism can be an ally to sustainable development in MINT (Mexico, Indonesia, Nigeria, Turkey) countries between 1995 and 2018. The study uses adjusted net saving and international tourism receipts in these countries as measures of sustainable development and tourism, respectively. In achieving its objectives, the study employs the augmented mean group (AMG) estimation technique to estimate the long-run parameters. Besides, mean group (MG) and common correlated effects MG techniques are employed to check the robustness of the estimates obtained via the AMG approach. The results from the three estimators show that tourism is indeed an ally to sustainable development in MINT countries since there is a significant positive relationship between tourism and sustainable development. In other words, tourism can put the MINT countries on the path to sustainable development. This implies that any policy that will enhance the performance of the tourism industry will ensure sustainable development in MINT countries. Thus, the governments of MINT countries should focus basically on achieving sustainable tourism development, as this will translate to sustainable development in their countries.
Defining ‘woman': A governmentality analysis of how protective policies are created in elite women's sport
Authors: Posbergh Anna
Published: January 2022

Women's sport remains a contested realm that frequently features standards and regulations premised on women's inferiority and physiological distinctions from men. In response to these purported sex-based differences, a range of protective policies have been implemented to ostensibly ensure women's safety and health, defend “fair competition” in women's sport, and/or prevent the violation of social and medical boundaries that define who is a “woman.” Yet, protective policies encompass a multitude of rationales and strategies, demonstrating the malleability of “protection” in terms of who is protected and why. In this article, I draw from Michel Foucault's theory of “governmentality” to investigate the nuances of protective policies, especially their placed importance on sex differences. To do so, I examine three case studies: World Athletics’ (WA) 2019 female eligibility policy, WA's 2019 transgender eligibility policy, and the International Olympic Committee's (IOC) consensus statement on relative energy deficiency in sport (RED-S). Using document texts and semi-structured interviews with eight scientists involved with developing the case studies, I find that protective policies are developed through messy and often contentious processes that selectively draw from varying knowledges and discourses. This then culminates in contrasting methods of defining, protecting, and governing women athletes and their bodies.
Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm
Authors: Goldstein Jake , Dieter Robert S , Bansal Vinod , Wieschhaus Keaton , Dieter Robert S , Bontekoe Emily , Hoppensteadt Debra , Fareed Jawed
Published: January 2022

Background

Patients with end-stage renal disease (ESRD) often present with an increased risk of cardiovascular disease. Conditions of compromised cardiovascular health such as atrial fibrillation (AFIB) and peripheral arterial disease (PAD) may alter biomarker levels in a way that reflects worsening ESRD. This study profiled biomarkers and laboratory parameters of endothelium dysfunction in patients with ESRD, categorized by additional AFIB and PAD conditions.

Methods

Citrated blood samples were collected from 95 patients with ESRD. Biomarker levels were measured from plasma samples using sandwich ELISAs, including tissue plasminogen activator (tPA), D-dimer, and nitrotyrosine. Lab parameters, including BUN, calcium, creatinine, parathyroid hormone, phosphate, alkaline phosphatase, ferritin, transferrin, and total iron capacity, and patient comorbidities were obtained from patient medical records. The comorbidities were determined through provider notes, and evidence of applicable testing.

Results

14.89% of patients were found to have atrial fibrillation (n = 14), 30.85% of patients were found to have peripheral arterial disease (n = 29), and 6.38% of patients were found to have both peripheral arterial disease and atrial fibrillation (n = 6). When compared to patients with only ESRD, patients with ESRD and PAD showed elevated levels of D-Dimer (p = .0314) and nitrotyrosine (p = .0330). When compared to patients with only ESRD, patients with atrial fibrillation showed elevated levels of D-Dimer (p = .0372), nitrotyrosine (p = .0322), and tPA (p = .0198).

Conclusion

When compared to patients with just ESRD, patients with concomitant PAD had elevated levels of Nitrotyrosine and D-dimer; while patients with concomitant Afib had elevated levels of nitrotyrosine, D-dimer, as well as tPA.
Role of clinical pharmacist in the palliative care of adults and elderly patients with cancer: A scoping review
Authors: Franco Julia , de Souza Rafael N , Lima Tácio de M , Moriel Patricia , Visacri Marília B
Published: January 2022

Objective

We conducted this scoping review to map and summarize scientific evidence on the role of clinical pharmacists in the palliative care of adults and elderly patients with cancer.

Data Sources

A literature search was performed in MEDLINE, PubMed Central, Embase, Web of Science, Scopus, and BVS/BIREME for studies published until November 22nd, 2020. Studies that reported work experiences adopted by clinical pharmacists in the palliative care of adults and elderly patients with cancer were included. Two independent authors performed study selection and data extraction. Any disagreements were resolved by discussion with the third and fourth authors. The pharmacist interventions identified in the included studies were described based on key domains in the DEPICT v.2.

Data Summary

A total of 586 records were identified, of which 14 studies fully met the eligibility criteria. Most of them were conducted in the United States of America (n  =  5) and Canada (n  =  5) and described the workplace of the pharmacist in clinic/ambulatory (n  =  10). Clinical pharmacists performed several activities and provided services, highlighting medication review (n  =  12), patient and caregivers education (n  =  12), medication histories and-or medication reconciliation (n  =  6). The pharmacist interventions were mostly conducted for patients/caregivers (n  =  13), by one-on-one contact (n  =  14), and by face-to-face (n  =  13). Pharmacists were responsible mainly for change or suggestion for change in therapy (n  =  12) and patient counselling (n  =  12). Pharmacist interventions were well accepted by the clinical team. Overall, studies showed that pharmacists, within an interdisciplinary team, had significant impacts on measured outcomes.

Conclusions

In recent years, there have been advances in the role of the pharmacist in palliative care of patients with cancer and there are great opportunities in this field. They play an important role in managing cancer pain and other symptoms, as well as resolving drug related problems. We encourage more research to be carried out to strengthen this field and to benefit patients with advanced cancer with higher quality of life.
Community Pharmacists’ Knowledge on Cancer and Screening Methods
Authors: Uygun Aysen , Caliskan Nazli Dilek , Tezcan Songul
Published: January 2022

Background and Objective

The aim of the study is to evaluate the knowledge of community pharmacists on cancer and screening methods.

Setting and Method

This study was a descriptive cross-sectional study and was conducted between January-June 2020 in Istanbul/Turkey. a structured questionnaire was applied to pharmacists as online. The questionnaire was prepared by the researchers and consisted of 49 questions; basic information about cancer (15 items), signs and symptoms (11 items), causes and risk factors (14 items), cancer screening methods (9 items).

Results

It was determined that the majority (>90%) of the pharmacists did not receive any education on cancer and/or cancer screening methods after graduation. The sufficient knowledge level of the pharmacists about cancer basics, signs and symptoms, and risk factors were found to be as 80%, 77%, and 67%, respectively. The internal consistency level of the questionnaire was calculated (Cronbach's alpha = 0.814). The item “Every woman should perform breast self-examination and notify a health professional when there is a change in breast appearance or feeling,” was answered correctly by 98% of the pharmacists. It was determined that 71% of the pharmacists gave the correct answer to the item “Women aged 21–30 years should have a PAP smear every 3 years”.

Conclusion

According to the results of the study, while the rate of sufficient knowledge level on cancer was found to be low, knowledge on cancer screening was found to be sufficient. We think that pharmacists should receive training on cancer and screening methods and to follow the guidelines closely.
CO2 laser-assisted sclerectomy surgery in the treatment of open-angle glaucoma in Chinese patients
Authors: Xin ZhiYuan , Chen Jeremy , Wang DaJiang , Wu Xing , Han Ying
Published: January 2022

Purpose: To evaluate the efficacy and safety of CO2-Laser Assisted Sclerectomy Surgery (CLASS) with 5-fluorouracil (5-FU) in treating open-angle glaucoma (OAG) in Chinese patients. Methods: This was a retrospective, uncontrolled, interventional case series. All patients from 2016 to 2017 who received CLASS were recruited in this study. The primary outcome was the change in intraocular pressure (IOP) and the number of IOP-lowering medications over a 12-month follow-up period. Adverse events were evaluated as secondary outcomes. Results: Data were collected from forty-two eyes of 31 patients. The average preoperative IOP was 31.33 ± 7.60mmHg. The mean percentage of IOP reduction from baseline at postoperative months (POM) 1, 3, 6, 9, and, 12 were 48.1% ± 24.6%, 51.4% ± 19.3%, 51.2% ± 17.2%, 50.9% ± 15.0%, 49.2% ± 16.3%, respectively (all P < 0.001). The number of glaucoma medications decreased from a baseline of 3.02 ± 0.81 to 0.05 ± 0.22, 0.10 ± 0.37, 0.12 ± 0.40, 0.17 ± 0.44, and 0.24 ± 0.58 at POM 1, 3, 6, 9, and 12, respectively (all P < 0.001). At POM 1, 3, 6, 9, and 12, complete success rates were 66.7%, 73.8%, 76.2%, 69.1%, and 71.4%, respectively. At POM 1, 3, 6, 9, and 12, qualified success rates were 71.4%, 82.0%, 85.3%, 83.3%, and 90.5%, respectively. Major postoperative complications include peripheral iris synechia, iris incarceration, and anterior chamber shallowing. Conclusions: CLASS with 5-FU shows safety and efficacy for decreasing IOP and the number of IOP-lowering medications over a 12-month follow-up period. It could be an alternative treatment for patients with OAG.
A comparative study of mental health diagnoses, symptoms, treatment, and medication use among Orthodox Jews
Authors: Pirutinsky Steven , Rosmarin David H.
Published: January 2022

Historical clinical reports and media narratives suggest that Orthodox Jews are reticent to seek treatment for mental illness, present only with serious concerns, and hesitate to comply with treatment in general and psychopharmacology in particular. On the other hand, recent developments, and some limited research, suggest that Orthodox Jews may be likely to seek and comply with treatment. The current study compared the diagnostic, symptomatic, and treatment characteristics of 191 Orthodox Jews and 154 control patients all presenting to a large private mental health clinic with offices throughout greater New York. Results indicated that the groups were largely demographically similar, and that their diagnoses did not significantly differ. Orthodox Jews initially presented with lower levels of symptoms, terminated with similar symptom levels, attended a similar number of sessions, and were equally likely to use psychopharmacological interventions of similar types, compared to controls. This was equally true of ultra-Orthodox and modern Orthodox Jews. Clinicians providing mental health services to Orthodox Jews should be aware of these findings, which contrast with existing clinical and popular stereotypes. Further, excessive efforts to protect Orthodox Jewish patients against stigma may be unnecessary and counterproductive.
“If you didn’t take a selfie, did you even vote?”: Embodied mass communication and citizenship models in “I voted” selfies
Authors: Butkowski Chelsea P
Published: January 2022

After participating in US elections, voters have begun to share “I voted” selfies, or networked self-portraits that display their political participation. “I voted” selfies exist at the intersection of competing ideals of citizenship, including dutiful citizenship, which centers civic duty and voting, and self-actualizing citizenship, which focuses on individualized and expressive forms of political participation. I argue that these images can be understood through historically resonant communication practices, namely, as a mediated manifestation of 19th-century political congregations that I term embodied mass communication. To trace how voters perform embodied visions of citizenship through shared practices of digital self-representation, I conducted a content analysis of “I voted” selfies posted to Twitter on US Election Day 2016. In these selfies, voters present their bodies as civic evidence, frame individual representations to signify visual collectives, and creatively contextualize their political participation. Their selfies suggest how representational rituals can reflect and reconstitute citizenship models.
Autologous Fat Grafting – A Step Forward in Wound Management
Authors: Saeed Komal , Khan Farid Ahmad , Qudus Saad Bin Abdul , Javed Sundas
Published: January 2022

Autologous fat grafting (AFG) is an emerging therapeutic option for wounds that are not ready for grafting. The regenerative potential of autologous fat lies in the adipose derived stem cells (ADSCs) contained within the stromal vascular fraction (SVF), which are capable of differentiating into multiple cell lineages. However to date, there has been no comprehensive evaluation of its efficacy in acute complicated wounds. This study aims to critically evaluate the efficacy and safety of AFG in cutaneous wound healing. Materials and Methods: This prospective, quasi experimental study was conducted in the Department Of Plastic Surgery, SIMS, Lahore, between June 2020 and June 2021. Thirty patients with pale granulation, not ready for grafting with no vital structure exposed were included in the study after detailed history, examination and were photographed pre and postoperatively. The procedure was performed under local anaesthesia. 40 to 80 ml fat was harvested from lower abdomen and after emulsification, placed over the wound wrapped in sufra tulle dressing. The dressing was changed on third postoperative day and outcome was assessed on clinical grounds. Results: Thirty patients (M:F Ratio 1.75:1) with mean age 30 years (Range 13-45 years) were included in this study with post traumatic (n = 23) and post infective (n = 7). Of 27 patients who completed their follow up, all had healthy granulation tissue which was later on grafted. Mean number of fat dressing sessions were 2 (Range 1-3). Conclusion: Autologous fat grafting has shown promising results for cutaneous wounds without any unacceptably high complication rates reported so far. Randomised controlled trials should be done on a larger scale to prove its efficacy in the management of complicated wounds.
Can arrows change the subjective perception of space? Exploring symbolic attention repulsion
Authors: Lawrence Rebecca K , Schneider Lucas R , Pratt Jay
Published: January 2022

The attention repulsion effect (ARE) refers to distortions in the perception of space for areas near the focus of attention. For instance, when attending to the right-hand side of the visual field, objects in central vision may appear as though they are shifted to the left. The phenomenon is likely caused by changes in visual cell functioning. To date, research on the ARE has almost exclusively used exogenous manipulations of attention. In contrast, research exploring endogenous attention repulsion has been mixed, and no research has explored the effects of nonpredictive arrow cues on this phenomenon. This gap in the literature is unexpected, as symbolic attention appears to be a unique form of attentional orienting compared with endogenous and exogenous attention. Therefore, this study explored the effects of symbolic orienting on spatial repulsion and compared it with an exogenously generated ARE. Across four experiments, both exogenous and symbolic orienting resulted in AREs; however, the magnitude of the symbolic ARE was smaller than the exogenous ARE. This difference in magnitude persisted, even after testing both phenomena using stimulus timing parameters known to produce optimal effects in traditional attentional cueing paradigms. Therefore, compared with symbolic attention, it appears that exogenous manipulations may tightly constrict attention resources on the cued location, in turn, potentially influencing the functioning of visual cells for enhanced perceptual processing.
Meta-Analysis of the Associations Among Constructs of Intrapersonal Emotion Knowledge
Authors: Park Juhyun , Zhan Xinyi , Gainey Kristin Naragon-
Published: January 2022

To better define the boundaries of conceptually overlapping constructs of intrapersonal emotion knowledge (EK), we examined meta-analytic correlations among five intrapersonal EK-related constructs (affect labelling, alexithymia, emotional awareness, emotional clarity, emotion differentiation) and attention to emotion. Affect labelling, alexithymia, and emotional clarity were strongly associated, and they were moderately associated with attention to emotion. Alexithymia and emotional awareness were weakly associated, and emotion differentiation was unrelated with emotional clarity. Sample characteristics and measures moderated some of the associations. Publication bias was not found, except for the alexithymia-emotional awareness association. This study helped to clarify the extent to which similarly defined constructs overlap or are distinct, which can inform our decision to adequately label important constructs and employ corresponding measures.
Healing Architecture in Healthcare: A Scoping Review
Authors: Simonsen Thorben , Sturge Jodi , Duff Cameron
Published: January 2022

Objectives:

The purpose of this scoping review is to identify evidence on how characteristics of healing architecture in clinical contexts impact clinical practice and patient experiences. Based on these insights, we advance a more practice-based approach to the study of how healing architectures work.

Background:

The notion of “healing architecture” has recently emerged in discussions of the spatial organization of healthcare settings, particularly in the Nordic countries. This scoping review summarizes findings from seven articles which specifically describe how patients and staff experience characteristics of healing architecture.

Methods:

This scoping review was conducted using the framework developed by Arksey and O’Malley. We referred to the decision tool developed by Pollock et al. to confirm that this approach was the most appropriate evidence synthesis type to identify characteristics related to healing architecture and practice. To ensure the rigor of this review, we referred to the methodological guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews.

Results:

There are two main findings of the review. First, there is no common or operative definition of healing architecture used in the selected articles. Secondly, there is limited knowledge of how healing architecture shapes clinical and patient outcomes.

Conclusions:

We conclude that further research is needed into how healing architectures make a difference in everyday clinical practices, both to better inform the development of evidence-based designs in the future and to further elaborate criteria to guide postoccupancy evaluations of purpose-built sites.
Effects of repetitive transcranial magnetic stimulation combined with cognitive training on resting-state brain activity in Alzheimer’s disease
Authors: Qin Yuanyuan , Zhang Fengxia , Zhang Min , Zhu Wenzhen
Published: January 2022

Objectives

Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to modulate brain plasticity, but the neural basis has been little addressed. The purpose was to investigate the effects of rTMS on resting-state brain activity in patients with Alzheimer’s disease (AD).

Methods

Seventeen patients with mild or moderate AD were enrolled and randomly divided into one of the two intervention groups: (1) real rTMS combined with cognitive training (real group, n = 9); (2) sham rTMS with cognitive training (sham group, n = 8). 10 Hz rTMS was used to stimulate the left dorsolateral prefrontal cortex and then the left lateral temporal lobe for 20 min each day for 4 weeks. Each patient underwent neuropsychological assessment and resting-state functional magnetic resonance imaging (rsfMRI) before and after treatment. The fractional amplitude of low frequency fluctuation (fALFF) of rsfMRI data in real group were: (1) compared to sham; (2) correlated with rTMS-induced cognitive alterations.

Results

Significantly increased fALFF in right cerebellum/declive, left lingual/cuneus and left cingulate gyrus, as well as decreased fALFF in left middle frontal gyrus were found after 10 Hz rTMS, but not after sham stimulation. Using these suprathreshold regions, we found that rTMS increased functional connectivity between the right cerebellum/declive and left precentral/postcentral gyrus. The fALFF increase in left lingual/cuneus and right cerebellum/declive was associated with significant improvement in cognitive function.

Conclusions

rTMS combined with cognitive training induced increased low frequency fluctuation neural oscillations and functional connectivity in brain regions subserving cognition, suggesting a possible neuronal mechanism of the beneficial effects of rTMS.
A Prospective Study of the Relationship Between Sleep Quality and Depression in Pregnancy
Authors: Chan Cassandra , Poon Shi Hui , Chua Tze-Ern , Razali Nurul Syaza , Tan Kok Hian , Chen Helen
Published: January 2022

Objective

Poor sleep and depression are common problems during pregnancy, but there has been little investigation into the association between them. This prospective study aims to examine the relationship between sleep quality and depression during pregnancy.

Methods

Pregnant women under 14 weeks’ gestation attending routine outpatient antenatal care in Singapore’s largest maternity hospital were recruited between 2012 and 2014. Women with multiple pregnancies and deemed at high risk of miscarriage were excluded. Six hundred and forty participants completed the Pittsburgh Sleep Quality Index (PSQI) and Edinburgh Postnatal Depression Scale (EPDS) at the three trimesters during pregnancy.

Results

Mean PSQI score was highest in the third visit, suggesting poorer quality sleep in the late third trimester compared to other trimesters. 15.6% of participants at each time point fulfilled the criteria for antenatal depression according to the EPDS cut-off score > 14. PSQI scores were significantly correlated with EPDS scores, and also prospectively predicted EPDS scores in all three trimesters.

Conclusion

Sleep quality in Singaporean pregnant women was poorest in the third trimester, and was associated with the development of depressive symptoms. With more than 1 in 10 women having antenatal depression, interventions targeting sleep quality might be particularly beneficial.
Rhino-orbital Mucormycosis in a COVID-19 Patient: The First Case in Malaysia
Authors: Chang Chee Yik , Gan Yi Lung , Zamri Fatin Izni , P. Radhakrishnan Anuradha
Published: January 2022

Mucormycosis is an aggressive and potentially fatal fungal infection caused by fungi of the order Mucorales. There has been an increase in the number of cases of rhino-orbital mucormycosis in people with COVID-19, particularly in India. Rhino-orbital-cerebral mucormycosis is the most common manifestation of mucormycosis associated with COVID-19. We report the first case of rhino-orbital mucormycosis in a diabetic patient with SARS-CoV-2 infection in Malaysia. The diagnosis of mucormycosis was confirmed by histopathological examination, but the fungal culture and PCR results were negative. He was treated with antifungal therapy and had extensive debridement. Treatment of mucormycosis requires a multidisciplinary approach that includes addressing underlying risk factors, effective antifungal therapy, and surgical debridement.
Cerebrospinal fluid evaluation in patients with progressive motor impairment due to critical central nervous system demyelinating lesions
Authors: Barakat Benan , Messina Steve , Nayak Shreya , Kassa Roman , Sechi Elia , Flanagan Eoin P , Kantarci Orhun , Weinshenker Brian G , Keegan B. Mark
Published: January 2022

Background

Elevated intrathecal immunoglobulin G (IgG; oligoclonal bands (OCBs)) or IgG in people with progressive motor impairment due to “critical” demyelinating lesions are of uncertain significance.

Objective

Compare clinical/radiological features of people with “critical” demyelinating lesion-induced progressive motor impairment with/without elevated intrathecal IgG synthesis.

Methods

A total of 133 people with progressive motor impairment attributable to “critical” demyelinating lesions (corticospinal tract location, consistent with the progressive motor deficit) were compared regarding clinical and radiological presentation with and without ≥2 unique cerebrospinal fluid (CSF) OCB and/or IgG index ≥0.85.

Results

Ninety-eight (74%) had CSF-elevated OCB and/or IgG index, higher with increased magnetic resonance imaging-lesion burden. No differences were found with/without CSF abnormalities in sex (46 of 98 female (47%) vs. 22 of 35 (63%), p = 0.11), onset-age (median 49 vs. 50 years, p = 0.5), progression from onset (62 of 98 (63%) vs. 25 of 35 (71%)), progression post-relapse (36 of 98 (37%) vs. 10 of 35 (29%), p = 0.4), and duration between demyelinating disease onset and CSF examination (30 (0–359) vs. 48 (0–323) months p = 0.7). “Critical” lesions were radiologically similar, most commonly cervical spine located (72 of 98 (74%) vs. 19 of 35 (54%), p = 0.18) both with/without CSF abnormalities.

Conclusions

People with “critical” demyelinating lesion-induced progressive motor impairment typically have elevated intrathecal IgG (OCB and/or IgG) and similar clinical and radiological presentation regardless of CSF findings, therefore representing valid presentations of progressive demyelinating disease.
Parental Mentalizing During a Pandemic: Use of Mental-State Language on Parenting Social Media Before and During the COVID-19 Pandemic
Authors: Yatziv Tal , Simchon Almog , Manco Nicholas , Gilead Michael , Rutherford Helena J. V.
Published: January 2022

The COVID-19 pandemic has been a demanding caregiving context for parents, particularly during lockdowns. In this study, we examined parental mentalization, parents’ proclivity to consider their own and their child’s mental states, during the pandemic, as manifested in mental-state language (MSL) on parenting social media. Parenting-related posts on Reddit from two time periods in the pandemic in 2020, March to April (lockdown) and July to August (postlockdown), were compared with time-matched control periods in 2019. MSL and self–other references were measured using text-analysis methods. Parental mentalization content decreased during the pandemic: Posts referred less to mental activities and to other people during the COVID-19 pandemic and showed decreased affective MSL, cognitive MSL, and self-references specifically during lockdown. Father-specific subreddits exhibited strongest declines in mentalization content, whereas mother-specific subreddits exhibited smaller changes. Implications on understanding associations between caregiving contexts and parental mentalization, gender differences, and the value of using social-media data to study parenting and mentalizing are discussed.
Return to Play and Player Performance After Meniscal Tear Among Elite-Level European Soccer Players: A Matched Cohort Analysis of Injuries From 2006 to 2016
Authors: Lavoie-Gagne Ophelie Z. , Korrapati Avinaash , Retzky Julia , Bernstein David N. , Diaz Connor C. , Berlinberg Elyse J. , Forlenza Enrico M. , Fury Matthew S. , Mehta Nabil , O’Donnell Evan A. , Forsythe Brian
Published: January 2022

Background:

Meniscal injuries are extremely common in soccer athletes, and little is known about postrecovery performance.

Purpose:

To (1) identify characteristics associated with return to play (RTP) to the same league level and (2) evaluate long-term effects that injury and management approach may have on player performance.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Using publicly available records, we identified athletes who sustained meniscal tears across the 5 major European soccer leagues (English Premier League, Bundesliga, La Liga, Ligue 1, and Serie A) between 2006 and 2016. Injured athletes were matched to controls 1:2 by demographics and performance. Investigations included rate of RTP to the same league level, reinjury, player characteristics associated with RTP within 2 seasons, long-term availability, field time, and performance metrics standardized to 90 minutes of play during the next 4 seasons.

Results:

A total of 250 players sustaining meniscal tears were included, of which 106 (42%) received surgical management. Median absence was 57.5 days (interquartile range [IQR], 35-92) or 7 games (IQR, 4-12). Rate of RTP was 70%, and the reinjury rate 5% if a player could RTP. Age greater than 30 years was a negative predictor for RTP (odds ratio [OR], 0.62; P = .002), whereas higher preinjury goals per game (OR, 2.80; P = .04) and surgical management (OR, 1.38; P = .002) were positive predictors for RTP. Surgical management was associated with higher long-term availability ( P < .01). As compared with the control, there were no significant differences in field time or performance metrics after RTP, either overall or by player position. As compared with nonoperative management, defenders undergoing surgery demonstrated decreased field time. Attackers and midfielders demonstrated similar field time and performance regardless of management.

Conclusion:

RTP of elite soccer athletes sustaining meniscal tear is contingent on age, preinjury performance, and management approach. Those who RTP to the same league level can be expected to demonstrate equivalent field time, performance, and long-term availability as noninjured athletes.
New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. XVII. Paraberzeliite, NaCaCaMg2(AsO4)3, an alluaudite-group member dimorphous with berzeliite
Authors: Pekov Igor V. , Koshlyakova Natalia N. , Belakovskiy Dmitry I. , Vigasina Marina F. , Zubkova Natalia V. , Agakhanov Atali A. , Britvin Sergey N. , Sidorov Evgeny G. , Pushcharovsky Dmitry Yu.
Published: January 2022

The new alluaudite-group mineral paraberzeliite was found in the Arsenatnaya fumarole, Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. In the deepest zone of Arsenatnaya, paraberzeliite (holotype) is associated with anhydrite, diopside, hematite, svabite, berzeliite, schäferite, calciojohillerite, magnesioferrite, ludwigite, fluorapatite, powellite, baryte, and rhabdoborite-group and aphthitalite-group members. In the middle zone of the fumarole, paraberzeliite occurs with hematite, calciojohillerite, badalovite, johillerite, nickenichite, tilasite, svabite, fluorophlogopite, sanidine, cassiterite, anhydrite, metathénardite and belomarinaite. Paraberzeliite forms prismatic crystals up to 0.2 mm × 0.2 mm × 1 mm often occurring in open-work aggregates. It is transparent, brown (from light to dark brown, sometimes with purple or red hue) or green (from pale greenish to yellow–green). The mineral is brittle, cleavage was not observed. The Mohs hardness is 3½. Dcalc is 3.811 g cm–3. Paraberzeliite is optically biaxial (+), α = 1.718(4), β = 1.728(4), γ = 1.742(4) and 2Vmeas. = 85(5)°. The chemical composition (wt.%, electron-microprobe; holotype) is: Na2O 6.43, CaO 16.65, MgO 11.64, MnO 1.65, CuO 0.06, Fe2O3 2.45, V2O5 1.10, As2O5 59.46, total 99.44. The calculated empirical formula based on 12 O atoms per formula unit is (Na1.20Ca1.71Mg1.66Mn0.13Fe3+0.18)Σ4.88(As2.98V0.07)Σ3.05O12. Paraberzeliite is monoclinic, C2/c, a = 12.3143(7), b = 13.0679(5), c = 6.7717(4) Å, β = 113.657(7)°, V = 998.14(10) Å3 and Z = 4. The crystal structure was solved from single-crystal X-ray diffraction data, R = 0.0349. Paraberzeliite is isostructural with other alluaudite-group minerals. Its simplified crystal chemical formula is A(1)CaA(2)'NaM(1)CaM(2)Mg2(TAsO4)3. The idealised formula is NaCa2Mg2(AsO4)3, or, according to the actual nomenclature of alluaudite-group arsenates, NaCaCaMg2(AsO4)3. The name paraberzeliite reflects the dimorphism of this alluaudite-group mineral with the arsenate garnet berzeliite, ideally (Ca2Na)Mg2(AsO4)3.
Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects
Authors: Rawley Orla , Swystun Laura L. , Brown Christine , Nesbitt Kate , Rand Margaret , Hossain Taneya , Klaassen Robert , James Paula D. , Carcao Manuel D. , Lillicrap David
Published: January 2022

von Willebrand factor (VWF) is an extremely cysteine-rich multimeric protein that is essential for maintaining normal hemostasis. The cysteine residues of VWF monomers form intra- and intermolecular disulfide bonds that regulate its structural conformation, multimer distribution, and ultimately its hemostatic activity. In this study, we investigated and characterized the molecular and pathogenic mechanisms through which a novel cysteine variant p.(Cys1084Tyr) causes an unusual, mixed phenotype form of von Willebrand disease (VWD). Phenotypic data including bleeding scores, laboratory values, VWF multimer distribution, and desmopressin response kinetics were investigated in 5 members (2 parents and 3 daughters) of a consanguineous family. VWF synthesis and secretion were also assessed in a heterologous expression system and in a transient transgenic mouse model. Heterozygosity for p.(Cys1084Tyr) was associated with variable expressivity of qualitative VWF defects. Heterozygous individuals had reduced VWF:GPIbM (<0.40 IU/mL) and VWF:CB (<0.35 IU/mL), as well as relative reductions in high-molecular-weight multimers, consistent with type 2A VWD. In addition to these qualitative defects, homozygous individuals also displayed reduced factor VIII (FVIII):C/VWF:Ag, leading to very low FVIII levels (0.03-0.1 IU/mL) and reduced VWF:Ag (<0.40 IU/mL) and VWF:GPIbM (<0.30 IU/mL). Accelerated VWF clearance and impaired VWF secretion contributed to the fully expressed homozygous phenotype with impaired secretion arising because of disordered disulfide connectivity.
Sex, gender and the pulmonary physiology of exercise
Authors: Dominelli Paolo B. , Molgat-Seon Yannick
Published: January 2022

In this review, we detail how the pulmonary system's response to exercise is impacted by both sex and gender in healthy humans across the lifespan. First, the rationale for why sex and gender differences should be considered is explored, and then anatomical differences are highlighted, namely that females typically have smaller lungs and airways than males. Thereafter, we describe how these anatomical differences can impact functional aspects such as respiratory muscle energetics and activation, mechanical ventilatory constraints, diaphragm fatigue, and pulmonary gas exchange in healthy adults and children. Finally, we detail how gender can impact the pulmonary response to exercise.
The evolving landscape of sex-based differences in lung cancer: a distinct disease in women
Authors: Ragavan Meera , Patel Manali I.
Published: January 2022

In stark contrast to a few decades ago when lung cancer was predominantly a disease of men who smoke, incidence rates of lung cancer in women are now comparable to or higher than those in men and are rising alarmingly in many parts of the world. Women face a unique set of risk factors for lung cancer compared to men. These include exogenous exposures including radon, prior radiation, and fumes from indoor cooking materials such as coal, in addition to endogenous exposures such as oestrogen and distinct genetic polymorphisms. Current screening guidelines only address tobacco use and likely underrepresent lung cancer risk in women. Women were also not well represented in some of the landmark prospective studies that led to the development of current screening guidelines. Women diagnosed with lung cancer have a clear mortality benefit compared to men even when other clinical and demographic characteristics are accounted for. However, there may be sex-based differences in outcomes and side effects of systemic therapy, particularly with chemotherapy and immunotherapy. Ongoing research is needed to better investigate these differences to address the rapidly changing demographics of lung cancer worldwide.