bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of quantitative characteristics of three cultures (peonies, hostas, irises) for their use in urban landscaping
Authors: Gusev Andrey Viktorovich , Mamaeva Natalia Anatol’evna , Savel’eva Galina Aleksandrovna , Khokhlacheva Yulia Anatol’evna
Published: May 2023

Abstract The purpose of this study is a scientifically based selection of representatives of the genera Paeonia L., Hosta L. and Iris L., promising for use in urban landscaping. The choice of research objects is determined by three criteria. These are: 1) representatives of the genera Paeonia, Hosta and Iris - large generic complexes with a large number of cultivars; 2) their cultivars are characterized by a wide morphological diversity; 3) in Russia, these cultures have long been actively used in landscape design. Their own set of characteristics has been studied for them. These signs are important for the selection of plants used in the greened objects of the city. The genus Paeonia is represented by a sample of 19 cultivars of P. lactiflora Pall. with a Japanese flower shape. The variability of three quantitative characteristics was studied - the length of the stem, its thickness at the base and the diameter of the flower. The genus Hosta is represented by a sample of 23 names. The variability was studied according to four characteristics - the length and width of the leaf blade, the leaf area, and the length of the petiole. The genus Iris is represented by a selection of 10 names. The variability of six characteristics was studied - the height of the plant, the number of flowers on the peduncle, the length of the flower and the width of the flower, the length and width of the leaf blade. Statistical processing of the obtained data was carried out using the program “Statistica Base”. Classical methods of data processing are used. The development of models of flower beds is carried out using the AutoCAD program. From the total composition of the sample, promising varieties and forms were selected for each culture under study. In representatives of the genus Paeonia - this is the cultivar ‘Bu-Te’. For the genus Hosta, these are the cultivars ‘Frances Williams’ and ‘Liberty’. In the genus Iris, it is a form of natural origin I. sibirica f. albiflora. Based on the data obtained, 3 mixborders were designed with the participation of these cultivars and one form of natural origin.
Effect of growth regulator paclobutrazol on size fitting of basil as a potted plant
Authors: Kurniawati Ani , Krisantini Krisantini , Firdausa Nadia Putri , Suketi Ketty
Published: May 2023

Abstract Basil (Ocimum basilicum L., Lamiaceae) is an herbal species cultivated primarily for culinary and aromatherapy. Basil plant height could reach more than 60 cm, and the plants tend to elongate, particularly in low-light environments. Our current study examined the potential uses of plant growth retardant paclobutrazol to control sweet basil height and improve potted basil’s ornamental quality. The treatment tested was paclobutrazol concentration at 0, 5, 10, and 20 ppm, applied as 100 mL media drenching per pot five weeks after planting. The control plants were water-drenched using the same volume at the same time. Basil treated with PBZ at 10 ppm or 20 ppm had significantly shorter, smaller shoot canopy diameter, node and leaf number than the control, but had a similar number of branches to the control. Basil treated with PBZ at 10 ppm or 20 ppm showed a more compact and bushy pot plants with the height to pot ratio of 1.5. Higher leaf chlorophyll, indicated by a higher index value, was recorded only with the PBZ concentration of 20 ppm compared to the control and the other PBZ concentrations. Basil growth responses to PBZ at 10 ppm were not significantly different from those treated with PBZ at 20 ppm, therefore the use of PBZ at a lower concentration (10 ppm) is preferable. Further studies should examine whether repeated PBZ applications at lower concentration is more effective in producing shorter and more compact pot plants.
The impact of Covid-19 pandemic on Aglaonema farming income: a comparison between the height and the post trend
Authors: Haryanto Lorenta In , Maulana Fandy Achmad , Sukrianto Sukrianto
Published: May 2023

Abstract The expansion of the COVID-19 pandemic from 2019 to 2021 has weakened the performance of critical industries in Indonesia. Aglaonema as one of the ornamental plants had a surge in demand as part of the farming industry until its height in 2020. Currently, the response to the demand for ornamental plants has declined considerably. This study discussed the revenue and income of Aglaonema farming during two periods, at height and the post of the COVID-19 pandemic, and analyzed the distribution of inputs data as information related to the allocation of production. The respondents comprised 32 active farmers from the Aglaonema community (ASA) in Depok City, who produced 10 varieties of premium Aglaonema, namely Super Pink, Suksom Jaipong, Khanza, Lotus Delight, Audrey, Tiara, Widuri, Adelia, Bidadari, and Pride of Sumatra. The data was collected from June to November 2022 using the recall method to tabulate data in 2020 (the year of the height of COVID-19 pandemic) and 2022 (the year of the post COVID-19 pandemic). The R/C ratio was used as a profit indicator by considering the implicit and explicit costs. The findings revealed that Aglaonema farming in Depok City was highly profitable at the height of the COVID-19 pandemic, evidenced by an R/C ratio of 7.50. The R/C ratio has changed in 2022 value to 1.79, indicating a decline in farming profitability. Suppose the farmers pay the implicit costs in the current situation, the farming becomes less profitable as shown by the return value which is just slightly above the break-even point.
CONECTANDO ASPECTOS SOCIOCULTURAIS AO PENSAMENTO COMPUTACIONAL EM ATIVIDADES DESPLUGADAS NO ENSINO FUNDAMENTAL
Authors: Salgado Luciana , Araujo Aleteia , Frigo Luciana Bolan , Bim Sílvia Amélia
Published: May 2023

RESUMO A inserção do pensamento computacional no ensino fundamental tem sido valorizada na educação contemporânea, no entanto boa parte dos docentes não tem formação na computação para trabalhar com esses conteúdos. Algumas iniciativas usam atividades desplugadas por causa da limitação de recursos nas escolas, entretanto identificamos que as propostas não conectam os aspectos socioculturais do público envolvido e o pensamento computacional. Este artigo avalia a ausência desses aspectos socioculturais e propõe uma atividade inclusiva contemplando todos esses fatores.
TECNOLOGIA NA EDUCAÇÃO INFANTIL: LETRAMENTO DIGITAL E COMPUTAÇÃO DESPLUGADA
Authors: Miguel Carolina Costa
Published: May 2023

RESUMO Neste artigo, propõe-se uma discussão para compreender como é possível promover o desenvolvimento do pensamento computacional mediante a aprendizagem de ciências e da tecnologia na educação infantil. Com o objetivo de pensar propostas que ampliem qualitativamente as interações entre professores e alunos no ambiente escolar e as interações entre as crianças e os recursos tecnológicos digitais e não digitais, são discutidas questões das linguagens de interação da interação humano-computador e apresentados caminhos para se trabalhar com crianças pequenas o letramento digital e a computação desplugada.
PENSAMENTO COMPUTACIONAL PARA CRIANÇAS POR MEIO DO PROJETO DE EXTENSÃO ACADEMIA HACKTOWN
Authors: Martins Danielle Juliana Silva , Oliveira Fábio Cristiano Souza
Published: May 2023

RESUMO Este trabalho apresenta o relato de experiência realizada no sertão de Pernambuco, por meio do Projeto Academia HackTown, que promove atividades de ensino que potencializam o pensamento computacional em crianças de 7 a 10 anos, em cursos de programação em jogos e robótica. Os cursos oferecidos fazem uso de metodologias como gamificação, computação desplugada, game learning, storytelling, clube de leitura, robótica educacional e programação, bem como adotam a ludicidade nas atividades propostas e compreendem que a diversidade metodológica promove a aprendizagem significativa.
COMPUTAÇÃO NA EDUCAÇÃO BÁSICA: EXPERIÊNCIAS E REFLEXÕES POSSIBILITADAS PELO PROJETO POR DENTRO DO COMPUTADOR
Authors: Beleti Junior Carlos Roberto , Bezerra Maytê Gouvêa Coleto , Santiago Junior Robertino Mendes , Sforni Marta Sueli de Faria
Published: May 2023

RESUMO Este artigo apresenta uma iniciativa de trabalho com tecnologias digitais voltada para crianças e adolescentes. São descritos ações, cursos e intervenções realizados por docentes e estudantes no projeto de extensão universitária Por Dentro do Computador. O desafio de organizar o ensino para esse público permitiu reconhecer a necessidade de novos estudos sobre a especificidade dos processos de aprendizagem e desenvolvimento de alunos desse nível de escolarização, para que se possa avançar na prática pedagógica com tecnologias digitais na educação básica.
Canine visceral leishmaniasis: risk factors and spatial analysis in an endemic area of Northeastern Brazil
Authors: Silva Samuel Souza , Macedo Lucia Oliveira de , Oliveira Jéssica Cardoso Pessoa de , Alves Leucio Câmara , Carvalho Gílcia Aparecida de , Ramos Rafael Antonio Nascimento
Published: May 2023

Abstract Canine visceral leishmaniasis is a disease caused by the protozoon Leishmania infantum, an important agent of zoonotic concern. In this study we determined the seroprevalence, risk factors and spatial distribution of infection by L. infantum among dogs in the Pajeú microregion of the Sertão region of Pernambuco, Brazil. Canine serum samples (n = 247) were tested using the Dual Path Platform (DPP®) rapid screening test and ELISA/S7® confirmatory test; and risk factors were assessed through univariate analysis and logistical regression. The spatial distribution of reactive dogs was analyzed by drawing a map using QGIS. Seroprevalence of 13.7% (34/247) was detected, with cases predominating in the municipality of Tabira (26.4%; 9/34). Age above 10 years was considered to be a risk factor associated with the presence of anti-L. infantum antibodies. The high overall prevalence and spatial distribution of positive cases showed wide dispersion of reagents dogs in the study area. Therefore, preventive measures are needed in order to reduce the risk of infection for animals and humans.
ARQUIVOS PESSOAIS DE CIENTISTAS E CONSERVACIONISTAS: A EXPERIÊNCIA DO INSTITUTO NACIONAL DA MATA ATLÂNTICA (INMA)
Authors: Gonçalves Alyne dos Santos
Published: May 2023

RESUMO Este artigo apresenta alguns resultados da nova linha de pesquisa do Instituto Nacional da Mata Atlântica (INMA), referente a arquivos de cientistas e conservacionistas. Entre os pioneiros da ciência e conservação da Mata Atlântica estão: Augusto Ruschi, Alvaro Aguirre, Adelmar Coimbra-Filho e Ibsen Câmara, cujos documentos encontram-se em tratamento arquivístico no INMA. Ao transformar suas memórias em patrimônio cultural e educativo, pretende-se reforçar ou criar identidades sociais conectadas a discursos ambientalmente responsáveis. Considerando o pouco que resta desse bioma, torna-se estratégico manter e organizar os registros de seu passado recente, ampliando e qualificando o acesso público a essas fontes.
“ARQUIVAR A PRÓPRIA VIDA” 25 ANOS DEPOIS: DIÁLOGOS COM PHILIPPE ARTIÈRES
Authors: Vieira Henrique Júlio
Published: May 2023

Resumo Este artigo pretende estabelecer diálogos entre as reflexões de Philippe Artières (1998) no ensaio “Arquivar a própria vida”, com questões teórico-críticas dos estudos literários e do trabalho com acervos de escritores. As práticas de arquivamento podem ser acessadas a posteriori na condição de rastros dos escritores, por meio da ordem dos fundos e dos discursos produzidos pelos titulares e pelos arcontes. Documentos dos acervos literários Ildásio Tavares e Judith Grossmann são analisados, a partir das imagens teóricas do rastro, traço e da sobrevivência, inseridas no paradigma indiciário da crítica biográfica, na condição de a posteriori, proposta pela psicanálise.
DO ARQUIVO À MONTAGEM: UMA ANÁLISE DA PRODUÇÃO E USOS DE IMAGENS PÚBLICAS E DOMÉSTICAS DOS ANOS DA DITADURA MILITAR NO BRASIL
Authors: Machado Patrícia
Published: May 2023

RESUMO Este artigo reflete sobre as relações entre a iniciativa de constituir um arquivo pessoal com imagens e documentos públicos e privados, as possibilidades de remontar esse material e as maneiras de enfrentar as políticas de silenciamento do período pós-Ditadura Militar brasileira a partir do cinema documentário. Nesse processo, cartas e imagens domésticas são usadas como fontes para narrativas femininas historicamente invisibilizadas. Propomos analisar o contexto de produção, usos e sentidos que ganham imagens públicas e domésticas em Fico te devendo uma carta sobre o Brasil, discorrendo sobre a história dessas imagens de arquivo, analisando como elas ganham o espaço público e de que forma contribuem para a constituição de uma memória coletiva. Outro interesse é compreender um movimento contrário: como e quando imagens públicas ganham um caráter memorialístico, familiar e afetivo.
Occurrence and ecological risk assessment of pharmaceutically active compounds in neotropical small basins, Brazil
Authors: Minillo Alessandro , Isique William Deodato , Cardoso Claudia Andrea Lima , Súarez Yzel Rondon
Published: May 2023

Abstract: Aim The aim of our study was to evaluate the contamination levels of selected pharmaceutically active compounds (PAC) and their potential ecological threat to forested streams. Methods Samples of stream water were collected in the second largest city in Mato Grosso do Sul State in center-west of Brazil. Physicochemical parameters and concentrations of PAC were quantified in samples collected in six field campaigns. Ecological risk assessment (ERA) based on risk quotient (RQ) was performed based on the maximum measured concentration of PAC in water. Results Six pharmaceutical compounds were successfully quantified in the forested streams, namely caffeine, naproxen, diclofenac, estriol, estradiol and ethinylestradiol. From the point of view of ecological risk, ethinylestradiol (22,57), estradiol (1,46), diclofenac (16.99) and caffeine (5.30) can be considered as priorities PAC, as they present moderate to high risks to aquatic organisms and may also cause damage to the food chain. Conclusions This study provides valuable information to emphasize the importance of continuous monitoring of forested streams in the west central region of the country, as well as efforts to control the input of these micropollutants into watercourses.
БЕЗОПАСНОСТЬ ЧЕЛОВЕКА В СЕТИ ИНТЕРНЕТ: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ
Authors: Дементьев Сергей Александрович
Published: May 2023

В этой статье предпринимается попытка изучить понятие безопасности человека в сети Интернет. Для этого автор разбирает понятия экзистенциальной, психологической и информационной безопасности в контексте виртуализации человеческих отношений в сети Интернет. Очерчены основные проблемные поля, связанные с каждым из вышеописанных видов безопасности, и сделан вывод о том, что глобальная сеть может считаться полноценной социальной реальностью, обладающей своими нормами и ценностями, к которым пользователь должен приспособиться. Основные риски для безопасности человека в сети Интернет связаны с низкой технической грамотностью пользователей и попустительским отношением к собственным персональным данным. Автор утверждает, что запретительные меры со стороны законодателя по отношению к глобальной сети не являются эффективными, и предлагает сосредоточить внимание на повышении культуры общения и повышении технической грамотности пользователей.
Desalting of Peptides to Prepare for Mass Spectrometry Analysis v2
Authors: not provided jconsi
Published: May 2023

Prior to proteomic analysis, peptide samples are desalted and eluted with freshly prepared 50% acetonitrile, 0.1% trifluoroacetic acid, followed by concentration in a vacuum concentrator. Peptides are then resuspended in freshly prepared 5% acetonitrile, 0.1% formic acid.
Older Adults Learning Digital Skills Together: Peer Tutors’ Perspectives on Non-Formal Digital Support
Authors: Korpela Viivi , Pajula Laura , Hänninen Riitta
Published: May 2023

In later life, digital support is predominantly received outside of formal education from warm experts such as children, grandchildren, and friends. However, as not everyone can rely on this kind of informal help, many older adults are at risk of being unwillingly left without digital support and necessary digital skills. In this article, we examine non-formal digital support and peer tutoring as a way to promote digital and social inclusion through the acquisition of necessary digital skills. First, we ask: (a) What is peer tutoring, in the field of digital training, from the peer tutors’ point of view? Then, based on the first research question, we further ask (b) what are the key characteristics of peer tutoring in relation to other forms of digital support? Our thematic analysis is based on semi-structured interviews (n = 21) conducted in Central Finland in 2022 with peer tutors aged between 63 and 84. Peer tutors offered individual guidance by appointment and also supported their peers in group-based settings. Based on our study, we argue that from the peer tutors’ point of view, being a peer entails sharing an age group or a similar life situation and provides an opportunity for side-by-side learning. Although every encounter as a peer tutor is different and the spectrum of digital support is wide, these encounters share specific key characteristics, such as the experience of equality between the tutor and the tutee that distinguishes non-formal peer support from formal and informal learning.
Re-Orienting Planning Practice
Authors: Doan Petra L.
Published: May 2023

This commentary reflects on the articles in the thematic issue on queering urban planning and municipal governance and the ways that they suggest that planning practice must be re-oriented to be more inclusive and incorporate more insurgent perspectives. Planning practice is susceptible to capture by neo-liberal corporate interests that marginalize vulnerable queer populations. More insurgent planning approaches are needed to resist the corporate take-over of queer spaces by empowering the voices of LGBTQ+ people.
Predicting a clinically narrow pelvis using neural network data analysis
Authors: Ziganshin A. M. , Dikke G. B. , Mudrov V. A.
Published: May 2023

Aim: to improve the efficiency of predicting a clinically narrow pelvis (СNP) using neural network data analysis and to evaluate its prognostic characteristics.

Materials and Мethods. The study was designed as a retrospective non-randomized clinical trial. An analysis of 184 born neonates was carried out: group 1 included 135 female patients whose delivery occurred through the natural birth canal, group 2 – 49 patients whose delivery was complicated by СNP development and ended up with emergency caesarean section. Examination of patients was carried out on the eve of childbirth (1–2 days) and included anamnesis, general and special obstetric examination, including pelvimetry, a clinical assessment of cephalopelvic disproportion was carried out during childbirth. The condition of newborns was assessed using the Apgar scale, height and body weight were measured. Neural network analysis was performed using the built-in Neural Networks module of SPSS Statistics Version 25.0 (IBM, USA).

Results. Despite hypothetically important role of anatomically narrowed pelvis in development of cephalopelvic disproportion, no significant inter-group differences were found. Significant parameters (abdominal circumference, uterine fundus height and woman’s weight, fetal head circumference, as well as data on the presence or absence of oligohydramnios and fetal macrosomia) were determined, which were included in the test database to create the basis for training the multilayer perceptron. Out of 135 patients of group 1, the prognosis was negative in 131 (97.0 %), positive in 4 (3.0 %); out of 49 patients in group 2, negative in 0 (0.0 %), positive in 49 (100.0 %). The forecast accuracy of the developed model was 98 % (sensitivity – 100 %, specificity –97 %). The information content of neural network data analysis in СNP predicting is presented in ROC analysis: area under the curve (AUC) = 0.99 (95 % confidence interval = 0.97–1.00). Neonatal anthropometric parameters were significantly higher in group 2 vs. group 1, and the Apgar score at 1 minute was correspondingly lower.

Conclusion. The use of neural network analysis of clinical data obtained on the eve of childbirth allows to predict СNP development at sufficient degree of accuracy (98.0 %), which, in the future, after being introduced into clinical practice, will optimize a choice of delivery method in patients at risk (anatomically narrow pelvis, large fetus), reduce emergency caesarean sections and improve birth outcomes.
Iron deficiency in the practice of a gynecologist: therapeutic efficacy
Authors: Dzhobava E. M. , Knysheva I. G. , Artizanova D. P.
Published: May 2023

Introduction. Iron deficiency (ID) of varying severity is the most common and rather serious extra-gynecological complication of adenomyosis resulting from meno/metrorrhagia of varying intensity, up to abnormal uterine bleeding requiring surgical hemostasis. Taking into account the chronic course of the disease, the complexity of radical therapy as well as a systemic effect ID also particularly affecting reproductive system, an issue of sufficient and timely ID correction in patients with adenomyosis of varying severity remains relevant.

Aim: to study an efficacy of ID therapy with drug containing ferrous fumarate and folic acid in patients with adenomyosis.

Materials and Methods. An observational study was conducted, which included 90 patients with isolated adenomyosis of varying severity: 30 patients with degree 1 adenomyosis (group 1), 30 patients with degree 2 adenomyosis (group 2), 30 women with degree 3–4 (group 3). All patients received ferrous fumarate plus folic acid for 30 days. To identify an ID variant, the level of serum ferritin, iron, transferrin, total iron-binding capacity of blood serum (TIBC), clinical blood test parameters such as hemoglobin level, erythrocyte count, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) were measured.

Results. A significant increase in ferrokinetic parameters was found in all patient groups. The most significant and clinically important dynamics was noted for serum iron level and TIBC. For instance, after the therapy, the level of serum iron increased in group 1 from 11.0 ± 0.6 μmol/l up to 15.0 ± 1.1 μmol/l, in group 2 – from 9.0 ± 1.6 μmol/l up to 14 .0 ± 0.8 μmol/l, in group 3 from 7.0 ± 1.3 μmol/l up to 12.0 ± 1.3 μmol/l (p < 0.05). In addition, a decreased TIBC was found in group 3: from 68.0 ± 1.8 μmol/l down to 58.0 ± 1.7 μmol/l (p < 0.05); in groups 2 and 3 TIBC level tended to insignificantly decrease.

Conclusion. The use of a preparation containing ferrous fumarate along with folic acid can effectively correct background ID of varying severity in patients with adenomyosis of varying intensity. An earlier and longer administration of iron preparations in patients with adenomyosis along with clinical and laboratory parameter monitoring is recommended to achieve more pronounced clinical effect.
Hemostasis parameters as prognostic biomarkers in gynecological cancer patients
Authors: Slukhanchuk E. V. , Bitsadze V. O. , Solopova A. G. , Khizroeva J. Kh. , Gris J.-C. , Elalamy I. , Shcherbakov D. V. , Shkoda A. S. , Pankratyeva L. L. , Ungiadze J. Yu. , Ashrafyan L. A. , Makatsariya A. D.
Published: May 2023

Hypercoagulation is a typical condition for cancer patients. In addition, various arms of the hemostasis system become involved in tumor growth, invasion, metastasis, neoangiogenesis as well as immunoevasion. The magnitude of activated hemostasis is driven by tumor phenotype. Parameters characterizing coagulation, intensity of fibrinolysis processes, platelet aggregation and activation as well as endothelial activation mirror magnitude of hemostasis activation in oncological process, but may also be considered as candidate markers of tumor progression and predictors of oncological diseases outcome. This review summarizes the study data assessing a value of predictive hemostasis biomarkers for overall survival and response to therapy in oncogynecology and mammology. The most promising biomarkers have been identified and used in the future for risk stratification as well as personalized patient management.
Impact of beta-D-glucan on survival and hematopoietic parameters of mice after exposure to X-rays
Authors: Murzina Elena V. , Sofronov Genrikh A. , Simbirtsev Andrey S. , Aksenova Natalia V. , Zagorodnikov Gennady G. , Veselova Olga M. , Zhirnova Natalya A. , Dmitrieva Elena V. , Klimov Nicolay A. , Vorobeychikov Evgeniy V.
Published: May 2023

BACKGROUND: There is a high need for drugs to reduce the side effects of radiation exposure on people in extreme, military, marine, space medicine, at nuclear facilities, in hematology and oncology.
AIM: To evaluate the antiradiation efficacy of beta-D-glucan derived from Oyster mushroom (Pleurotus ostreatus) after total body irradiation of mice in terms of survival and hematopoiesis.
MATERIALS AND METHODS: The study was conducted on a mouse model of the acute radiation hematopoietic syndrome caused by exposure to X-rays. Radioprotective effect of intragastrically administered beta-D-glucan derived from Pleurotus ostreatus at a dose of 500 mg/kg was studied. The parameters of the 30-day survival of irradiated mice were analyzed using the KaplanMeyer method. Dose reduction factor of X-ray radiation was calculated to evaluate the radiomodifying effect. The hematopoiesis was assessed by the endogenous colony formation test and hematological parameters in irradiated mice. Statistical analysis was performed using the Statistica 8.0 software.
RESULTS: The antiradiation efficacy of orally administered beta-D-glucan has been shown. DRF was 1.16 when the drug was administered 0.5 hours before irradiation and 1.06 during therapeutic use (after 1 or 2 hours). There was a decrease in weight loss in lethally irradiated mice and its faster recovery. Single oral administration of beta-D-glucan at a dose of 500 mg/kg stimulated the growth of splenic endogenous colony-forming units in mice on day 9 after total body irradiation at doses of 7 and 7.8 Gy, contributed to a decrease in the severity of leukopenia and thrombocytopenia. The antiradiation effect of beta-D-glucan was associated with an increase in the viability of bone marrow stem cells and a faster restoration of hematopoiesis.
CONCLUSIONS: The results obtained indicate the possibility of using beta-D-glucan from P. ostreatus both before irradiation to increase the radioresistance and for early therapy of the hematopoietic syndrome of acute radiation sickness.
Role of the intestinal microbiota in the pathogenesis of multiple sclerosis. Part 2. Gut microbiota as a predisposition factor for the multiple sclerosis development
Authors: Abdurasulova Irina N.
Published: May 2023

This part of the review focuses on the proposed involvement of the gut microbiota in the realization of the genetic risk of multiple sclerosis, the formation of the intestinal microbiome in early life, and provides data supporting the hypothesis that aberrant formation of the intestinal microbiota in early life may be a predisposing factor to multiple sclerosis.
Reducing of the respiratory effects of dizocilpine by recombinant interleukin-1β in experiment
Authors: Tumanova Tatiana S. , Merkurjev Vladimir A. , Danilova Galina A. , Aleksandrov Viacheslav G.
Published: May 2023

BACKGROUND: For a deeper understanding of the pathogenesis of COVID-19, it is necessary to study the mechanisms that implement the influence of pro-inflammatory cytokines on the processes of regulation of the external respiratory system. In experiments on anesthetized rats, the effect of the pro-inflammatory cytokine interleukin-1 on the respiratory effects of dizocilpine (MK-801), which has an inhibitory effect on neurotransmitter systems involved in the control of the respiratory system, was studied. It was considered that, first of all, dizocilpine is a highly effective non-competitive NMDA-type glutamate receptor blocker.
AIM: The objectives of the study were to identify the effect of the influence of dizocilpine on the parameters of the breathing pattern and to assess the degree of change in this effect when dizocilpine was administered against the background of an elevated systemic level of interleukin-1.
MATERIALS AND METHODS: The study was performed on 24 anesthetized tracheostomy spontaneously breathing rats. To register the volume-time parameters of external respiration, a pneumotachographic technique was used. In the process of processing the obtained results, the value of the recorded parameter was determined immediately before the introduction of MK-801 and 1 min after its introduction
RESULTS: At a dosage of 0.1 mg/kg, dizocilpine was found to cause a reversible short-term decrease in respiratory rate, tidal volume, and minute respiratory volume. It has been shown that this effect of dizocilpine does not appear after intravenous administration of interleukin-1 (at a dosage of 2 g/kg). The results obtained confirm the assumption about the effect of an elevated systemic level of interleukin-1 on the state of neurotransmitter systems involved in the control of respiration.
CONCLUSIONS: Based on the correlation of the obtained results with the literature data, an assumption was made about a change in the state of NMDA-type glutamate receptors under the influence of pro-inflammatory cytokines, which may be one of the mechanisms of cardiorespiratory dysfunctions observed in a systemic inflammatory reaction accompanied by hypercytokinemia.
Visualisation of kupffer cells in the rat liver with poly- and monoclonal antibodies against microglial-specific protein Iba-1
Authors: Nikitina Inga A. , Razenkova Valeria A. , Kirik Olga V. , Korzhevskii Dmitrii E.
Published: May 2023

BACKGROUND: A necessary attribute of any study, which is related to the cell biology of various structural components of the digestive tract, is the usage of modern immunohistochemical methods. One of the most difficult objects are resident liver macrophages, or Kupffer cells. This determines the high significance to develop a reliable approach for Kupffer cells visualization.
AIM: The aim of the study was to develop a protocol for the immunohistochemical research of Kupffer cells in rat liver using two types of primary antibodies against Iba-1, and to analyze the advantages and disadvantages of this approach, taking into account the use of zinc-ethanol-formaldehyde as a fixative.
MATERIALS AND METHODS: The study was carried out on liver samples of adult Wistar rats (n = 5). Goat polyclonal and rabbit monoclonal antibodies against calcium-binding protein Iba-1 were used for the ligh microscopy immunohistochemistry assay of resident liver macrophages.
RESULTS: Using two types of antibodies it was shown by quantitative analysis that rabbit monoclonal antibodies most completely reveal Iba-1-immunopositive structures compared to goat polyclonal antibodies. Fixation with zinc-ethanol-formaldehyde made it possible to reveal Iba-1-immunopositive cells in all studied rat liver samples.
CONCLUSIONS: Iba-1 immunohistochemistry using rabbit monoclonal antibodies was considered as the most optimal immunohistochemical approach. Fixation with zinc-ethanol-formaldehyde preserves the antigenic epitopes and allows the effective use of different antibodies.
The concept of endothelial transcytosis as a theoretical prerequisite for the development of prevention and treatment of atherosclerosis
Authors: Parfenova Nina S. , Tanyanskiy Dmitry A.
Published: May 2023

This part of the review focuses on the proposed involvement of the gut microbiota in the realization of the genetic risk of multiple sclerosis, the formation of the intestinal microbiome in early life, and provides data supporting the hypothesis that aberrant formation of the intestinal microbiota in early life may be a predisposing factor to multiple sclerosis.
Detection of macrophages in human and rat heart using a single antibody variant
Authors: Guselnikova Valeria V. , Pavlova Valeria S. , Razenkova Valeria A. , Kirik Olga V. , Korzhevskii Dmitrii E.
Published: May 2023

BACKGROUND: Resident macrophages of the myocardium are necessary for the normal development and functioning of the cardiovascular system and play an important role in the pathogenesis of a number of cardiovascular diseases.
AIM: To develop a universal methodological approach for the immunohistochemical identification of macrophages in the human and rat myocardium.
MATERIAL AND METHODS: For the study, samples of the myocardium of people of both sexes aged from 28 to 52 years (n=7) and Wistar female rats (at the age of 15 months, (n=5)) were used. The work was performed using immunohistochemical staining method.
RESULTS: The possibility of using polyclonal antibodies against the calcium-binding protein Iba1, which is a well-known microglial marker marker, for the detection of macrophages in the myocardium was shown. An optimal drug processing protocol was developed, the use of which makes it possible to equally effectively detect macrophages in the human and rat myocardium using only one antibody variant.
CONCLUSION: A universal methodological approach has been proposed for the identification of macrophages in the human and rat myocardium, which can be successfully used in scientific and clinical diagnostic studies.
The Importance of Place and Space
Authors:   , Jose Rini , Welles Seth L
Published: May 2023

Hepatitis C virus (HCV) is a bloodborne infectious disease that has increased in prevalence across the United States. In recognition of this issue, the U.S. has committed to eliminating HCV infection by the year 2030. Although we have made strides in expanding availability of HCV screening and curative therapies, eliminating HCV will require a more granular understanding of the drivers behind HCV infection, including the importance of contextual and structural barriers. This dissertation harnesses the inherent strengths of surveillance data while simultaneously addressing epidemiologic biases that often plague these ubiquitous data sources. Surveillance data collected by the Philadelphia Department of Public Health (PDPH) will examine and explore contextual and individual risk factors of HCV infection and subsequent treatment in three chapters. The first study explores the association between availability of healthcare and HCV, geospatially. The second study corrects for misclassification of treatment of HCV then uses this corrected measure to quantify the relationship between healthcare availability and HCV treatment within a multilevel logistic model. In our final study, we use propensity scores to measure and model the impact of selection within the data source, then correct for this bias. We hope this research will contribute to the growing body of HCV literature, as well as highlight the importance of considering structural, contextual factors that affect testing and treatment of HCV. Given the limited resources of public health departments, a coordinated approach to testing and treatment among particularly high-need, high-risk communities are integral towards eliminating HCV in the next ten years.
Evaluation of Hospital Information Systems (HIS) in terms of their Suitability for Tasks
Authors: Gutlapalli Sai Srujan , Mandapuram Mounika , Reddy Manjunath , Bodepudi Anusha
Published: May 2023

In the context of hospital information systems (HIS), "suitability for the task" refers to several factors, including not imposing additional tasks on users, executing everyday activities in their entirety, and displaying all relevant information on the screen. In this descriptive cross-sectional study, a multi-stage sampling strategy was utilized to select hospitals to participate in the study. In other words, the first thing done was to locate hospitals with companies that supplied them with health information systems. Then, one hospital was selected among those that were provided funding by each of the companies. The ISO Metric Standard Questionnaire 9241 was utilized for this investigation. The evaluation of HIS aptitude for the job will be based on his responses to these 15 questions in the questionnaire. The data were examined by employing descriptive tests and the software SPSS. According to the investigation results, the average number of HIS characteristics suitable for the undertaking was 3.04 out of 5. This feature has an average rating of 2.96 out of 5 stars from paraclinical users. The scores of 3.03 and 3.13 given by secretaries and nurses, respectively, are presented here. Items that received bad ratings, such as the imposition of tasks that were not within the user's obligations, highlight the fact that the majority of users consider that such systems are not following their responsibilities, despite all of the claims that have been made regarding the benefits of computer information systems in the field of medicine. In other words, these kinds of systems have not only failed to simplify the regular duties of their users, but they have also resulted in the users having to execute those actions multiple times. The users initially write the data down on paper before entering it into the digital information systems. As a result, those responsible for developing computerized information systems used in healthcare should emphasize the appropriateness of these systems for the job.
ALTERNATİF HABER SİTELERİNİN SOSYAL MEDYA GAZETECİLİĞİ PRATİKLERİ: GZT, SPUTNİK TÜRKİYE VE ODA TV ÖRNEĞİ
Authors: Livberber Tuba , Ayvaz Süheyla
Published: May 2023

Dijitalleşmeyle birlikte habercilik alanındaki çeşitlenmeler hem biçimsel hem de içeriksel açıdan oldukça artmıştır. Yeni iletişim teknolojilerinin sunduğu özellikler geleneksel ve alternatif gazetelerin haber pratiklerini değiştirmiş ve değiştirmeye devam etmektedir. Bu süreçte özellikle alternatif medya, kitlelere ulaşma ve sesini duyurma noktasında yeni fırsatlar elde etmiş, kendine yeni bir alan yaratma olanağını yakalamıştır. Alternatif medya ilk olarak internet gazeteciliğiyle kendine alan açmaya başlamış ardından sosyal medya gazeteciliğiyle daha fazla kitleye ulaşmaya başlamıştır. Günümüzde sosyal medya platformlarının haber edinme ve paylaşma bağlamında sıklıkla tercih edilmesi, sosyal medya gazeteciliğini önemli kılmaktadır. Bu doğrultuda bu çalışmada, alternatif haber sitelerinin sosyal medya gazeteciliği pratikleri incelenmiştir. Bu bağlamda, genel tarama modeli çerçevesinde GZT, Sputnik Türkiye ve Oda TV haber sitelerine ilişkin sayfaların sosyal medya gazeteciliği açısından incelenmesi amaçlanmıştır. Çalışmada söz konusu haber sitelerinin 25-30 Haziran 2021 ile 25-30 Haziran 2022 tarihleri arasındaki YouTube, Facebook, Instagram ve Twitter hesaplarındaki takipçi/hayran/abone sayıları, hakkında konuşanlar, haftalık takipçi/hayran/abone artış oranları, ileti dağılımları ve ileti türleri ile etkileşim oranları incelenerek sosyal medya gazeteciliği açısından değerlendirilmiştir. Bu kapsamda, analiz edilen internet siteleri arasından sırasıyla GZT, Oda TV ve Sputnik Türkiye’nin sosyal medya gazeteciliği pratiklerinde etkin olduğu saptanmıştır.
ZEYTİNLİADA MERYEM ANA KİLİSESİ’NDE ELE GEÇEN SİKKELER
Authors: Murat Mehmet Kayhan
Published: May 2023

Zeytinliada, Marmara Denizi’nde Balıkesir İli’nin Erdek İlçesi’nin 250 m açıklarında yer almaktadır. Antik Dönem’de Artake ve Arteceon adlarıyla anılan adadaki kazılara 2006 yılında başlanıp 2016 yılında bitirilmiştir. Adanın kuzeydoğusunda yer alan Meryem Ana Kilisesi 2006-2009 yıllarında yapılan kazılarda açığa çıkarılmıştır. Erken Bizans Dönemi’ne tarihlenen kilise 3 nefli bazilikal bir plana sahiptir. Bu çalışmada kilisedeki kazılarda ele geçen küçük buluntular arasında yer alan 44 sikke incelenmiştir. Kilisede ele geçen 44 sikkeden 36’sı tanımlanmış, 8 sikke uğradıkları aşırı bozulmadan dolayı tanımlanamamıştır. Tanımlanan sikkeler Roma, Bizans ve Osmanlı İmparatorluğu Dönemleri’ne aittir. Sikkeler 10 farklı imparatorun hanedanlık yıllarında darp edilmiştir. Zeytinliada Meryem Ana Kilisesi’nde ele geçen sikkeler 4 ayrı darphaneye ait olup 7 farklı birimdedir. İncelenen sikkelerden en erken tarihlisi MS 276-282, en geç tarihlisi 1861 yıllarına aittir. Sikkelerin genel çoğunluğunu 32 sikkeyle kilise ile çağdaş olan Bizans sikkeleri oluşturmaktadır. Bizans sikkelerinden 16 tanesi Erken Bizans Dönemi’ne, 2 tanesi Orta Bizans Dönemi’ne tarihlenmektedir. İncelediğimiz sikkeler yapının tarihlendirilmesi ve dönemin sikke dolaşımı hakkında önemli bilgiler vermektedir.
Thermodynamic analysis of the apci skikda liquefaction process
Authors: DERBAL Chaima , HAOUAM Abdallah
Published: May 2023

In this paper, the mixed refrigeration cycle of Skikda APCI (Air Products and Chemicals Inc.) process in Algeria was studied thermodynamically in order to determine the optimal operat-ing conditions. The energy and exergy balance equations for each process component were es-tablished. The distribution of the exergy destruction of the basic cycle equipment revealed that the compressors had the highest exergy destruction rate. The effects of operating conditions on performance coefficient of the cycle (COP) and exergy efficiency of the APCI process were evaluated; mainly the inlet temperature of the compressors, natural gas (NG) temperature af-ter cooling in the main cryogenic heat exchanger (MCHE) and inlet temperature of the mixed refrigerant (MR) expansion valve. The results of the numerical simulation validated using Aspen HYSYS software indicate that the COP and exergy efficiency of the basic cycle are 2.66 and 59.99% respectively. These results can be improved by reducing the inlet temperature of the compressor and the expander as well as that of the NG after cooling in the MCHE. Finally, the results of the optimization performed using the genetic algorithms (GA) are in agreement with those of the literature. They show signs of improvement in the COP and exergy efficiency of the APCI process by 1.48% and 3.64% respectively compared to the basic cycle.
An investigation of the MHD Cu-Al2O3/H2O hybrid-nanofluid in a porous medium across a vertically stretching cylinder incorporating thermal stratification impact
Authors: PAUL Ashish , MANI NATH Jintu , KANTI DAS Tusar
Published: May 2023

The thermal aspects of 𝐶𝑢 − 𝐴𝑙2𝑂3/𝑤𝑎𝑡𝑒𝑟 hybrid nanofluid in a porous medium across a ver-tically stretched cylinder with the incorporation of heat sink/source impact are investigated in this numerical study. A magnetic field along the transverse direction of the stretching cylinder and the thermal buoyancy effect is considered in the flow problem. A pertinent similarity vari-able has been employed to simplify the boundary layer equations which govern the flow and convert the coupled nonlinear partial differential equations into a set of non-linear ordinary differential equations. The numerical results are computed using the 3-stage Lobatto IIIa tech-nique, Bvp4c. The impacts of non- dimensional parameters, including Prandtl number, heat source/sink parameter, magnetic parameter, porosity parameter, curvature parameter, ther-mal stratification parameter, and thermal buoyancy parameter on the velocity curve, thermal curve, skin-friction coefficient, and Nusselt number, are illustrated graphically and numeri-cally portrayed in tables. The important results demonstrate that hybrid nanofluids are more thermally conductive than nanofluids. Therefore, the hybrid nanofluid has a considerable im-pact on improving thermal developments. It has been found that the absolute skin friction of the hybrid nanofluid is up to 31% higher compared to the nanofluid. The heat transport rate of the hybrid nanofluid is 7.5% enhanced in comparison to the nanofluid. The influence of heat stratification of the hybrid nanofluid flow is appreciably significant.
Predicting heat transfer performance of Fe3O4-Cu/water hybrid nanofluid under constant magnetic field using ANN
Authors: TAŞKESEN Edip , DIRIK Mahmut , TEKIR Mutlu , PAZARLIOĞLU Hayati Kadir
Published: May 2023

In this study, the experimental results using mono (Fe3O4/water and Cu/water) and hybrid (Fe3O4-Cu/water) type nanofluid with nanoparticle volume concentrations of (0≤φ≤0.02) under laminar flow conditions (994≤Re≤2337) were compared with the results obtained by ANN. While the Reynolds number (Re), hydraulic diameter (Dh), thermal conductivity (k) of working fluid, and volume concentration of the nanoparticles (φ) were selected as input layers, the Nusselt number (Nu) were considered as output layers. The %75 of the findings obtained from experiments were used to train Artificial Neural Network (ANN). The estimated data by ANN is in perfect agreement with the experimental data. The success of ANN was deter-mined by comparing it with SVM, Dec Tree, and their variations. Mean square error (MSE), root mean square error (RMSE), R-sq (R2), and mean absolute error (MEA) were considered in evaluating the results obtained. According to findings, MAE 0.00088274, MSE 1.4106e-06, RMSE 0.0011877 and R2 1.00 were measured. These findings show that the use of ANN is a feasible way to predict the convective heat transfer performance of hybrid nanofluid under a magnetic field (MF).
Спектрофотометрический способ идентификации пропранолола и небиволола в мягких лекарственных формах, приготовленных на геле «Тизоль»
Authors: Попова М.И. , Кобелева Т.А. , Сичко А.И. , Шаповалова Е.М.
Published: May 2023

Для качественной оценки лекарственных средств из фармакологической группы «Бетаадреноблокаторы» в мягких лекарственных формах, приготовленных на гидрофильной основе «Тизоль» («Пропранозоль» и «Небиволозоль»), были построены спектры поглощения пропранолола и небиволола в различных pH-средах, рассчитаны молярные показатели при экстремумах, разработаны методики с использованием спектрофотометрии в УФ-области. В ходе исследования применяли метод производной спектрофотометрии, где строились спектральные кривые второго порядка, определялись числовые значения молярных показателей поглощения второй производной.
Актуальность государственных информационных систем обеспечения градостроительной деятельности
Authors: Горбачѐв А.Ю. , Гулякин Д.В.
Published: May 2023

Развитие цифровых технологий происходит во всем мире стремительными темпами. Возможность цифровизации имеет место быть в любой отрасли человеческой деятельности. Строительная отрасль – не исключение. Однако, развитие цифровых технологий в строительстве, процесс столь многогранен, динамичен и разнороден, сколько и сама сфера деятельности. Мы уже знаем о таком инструменте цифровых технологий, как BIM (Building Information Model) – цифровая модель здания. Также, на сегодняшний день все чаще встречается аббревиатура ТИМ (Технология информационного моделирования). Суть в том, что ТИМ есть совокупность всех аспектов цифровой среды в строительстве, когда BIM лишь его часть, пусть и не самая малая. Вникая во всевозможные аббревиатуры, любая дорога приводит нам к родоначальнику – ГИСОГД. ГИСОГД предназначена для консолидации и работы с базами данных строительной сферы, и имеет схожие преимущества с BIM технологиями, это: повышение качества государственного менеджмента, сокращение сроков и оптимизация всего строительного процесса.