bluuebunny/crossref_metadata_2025 huggingface dataset:
Intraoral Scanning for Monitoring Dental Wear and Its Risk Factors: A Prospective Study
Authors: Díaz-Flores García Víctor , Freire Yolanda , David Fernández Susana , Gómez Sánchez Margarita , Tomás Murillo Beatriz , Suárez Ana
Published: May 2024

Dental wear arises from mechanical (attrition or abrasion) and chemical (erosion) factors. Despite its prevalence and clinical significance, accurately measuring and understanding its causes remain challenging in everyday practice. This one-year study with 39 participants involved comprehensive examinations and full-arch intraoral scans at the start and after 12 months. Volume loss exceeding 100 µ on each tooth’s surfaces (buccal, lingual/palatine and incisal/occlusal) was measured by comparing three-dimensional scans from both time points. This study also assessed factors such as abrasion and erosion through clinical exams and questionnaires. There were no significant differences in dental wear in participants with sleep bruxism. However, noticeable wear occurred in the front teeth of those with waking bruxism and joint-related symptoms. Increased wear was associated with frequent consumption of acidic drinks, regular swimming, dry mouth, nocturnal drooling and heartburn, while no significant wear was found in patients with reflux. The used methodology proved effective in accurately assessing the progression of dental wear, which is important as many patients may initially be asymptomatic. The variability observed in dental wear patterns underscores the need to develop specific software applications that allow immediate and efficient comparison of wear areas based on extensive analysis of patient databases.
Can SPAD Values and CIE L*a*b* Scales Predict Chlorophyll and Carotenoid Concentrations in Leaves and Diagnose the Growth Potential of Trees? An Empirical Study of Four Tree Species
Authors: Wei Lai , Lu Liping , Shang Yuxin , Ran Xiaodie , Liu Yunpeng , Fang Yanming
Published: May 2024

Photosynthetic pigments are fundamental for plant photosynthesis and play an important role in plant growth. Currently, the frequently used method for measuring photosynthetic pigments is spectrophotometry. Additionally, the SPAD-502 chlorophyll meter, with its advantages of easy operation and non-destructive testing, has been widely applied in land agriculture. However, the application prospects of its test results in horticultural plants have not yet been proven. This study examines the reliability of SPAD values for predicting chlorophyll concentrations. Using fresh and senescent leaves from four common horticultural plants, we measured SPAD values, photosynthetic pigment concentrations, and leaf color parameters. A generalized linear mixed model demonstrated that SPAD values are a reliable indicator for predicting chlorophyll concentrations, yet interspecific variations exist. Based on the predictive power of SPAD values for chlorophyll, we first propose an Enrichment Index (CEI) and a Normal Chlorophyll Concentration Threshold (NCCT). The CEI can be used to compare SPAD values among different species, and the NCCT value can serve as a more accurate indicator for assessing the growth potential of old trees. However, due to a limited sample size, further research with larger samples is needed to refine the diagnosis of plant growth potential and enhance the management of ornamental plant cultivation.
Exploring the Feasibility of an Electronic Tool for Predicting Retention in HIV Care: Provider Perspectives
Authors: Kromash Jacqueline , Friedman Eleanor E. , Devlin Samantha A. , Schmitt Jessica , Flores John M. , Ridgway Jessica P.
Published: May 2024

Retention in care for people living with HIV (PLWH) is important for individual and population health. Preemptive identification of PLWH at high risk of lapsing in care may improve retention efforts. We surveyed providers at nine institutions throughout Chicago about their perspectives on using an electronic health record (EHR) tool to predict the risk of lapsing in care. Sixty-three percent (20/32) of providers reported currently assessing patients’ risk for lapsing in care, and 91% (29/32) reported willingness to implement an EHR tool. When compared to those with other job roles, prescribers agreed (vs. neutral) that the tool would be less biased than personal judgment (OR 13.33, 95% CI 1.05, 169.56). Prescribers were also more likely to identify community health workers as persons who should deliver these interventions (OR 10.50, 95% CI 1.02, 108.58). Transportation, housing, substance use, and employment information were factors that providers wanted to be included in an EHR-based tool. Social workers were significantly more likely to indicate the inclusion of employment information as important (OR 10.50, 95% CI 1.11, 98.87) when compared to other participants. Acceptability of an EHR tool was high; future research should investigate barriers and evaluate the effectiveness of such a tool.
Predictive Factors Associated with Future Decline in Swallowing Function among Japanese Older People Aged ≥ 75 Years
Authors: Iwai Komei , Azuma Tetsuji , Yonenaga Takatoshi , Sasai Yasuyuki , Komatsu Yoshinari , Tabata Koichiro , Nomura Taketsugu , Sugiura Iwane , Inagawa Yujo , Matsumoto Yusuke , Nakashima Seiji , Abe Yoshikazu , Tomofuji Takaaki
Published: May 2024

Predictive factors associated with a decline in swallowing function after 2 years were examined in 3409 Japanese older people aged ≥ 75 years who had undergone a dental checkup in Gifu Prefecture, Japan. Participants with normal swallowing function in a baseline survey in April 2018 were followed for 2 years. Swallowing function was assessed using a repetitive saliva swallowing test. In our study, 429 participants (13%) who were swallowing less than three times in 30 s based on a repetitive saliva swallowing test after 2 years were diagnosed as those with decline in swallowing function. Multivariate logistic regression analyses showed the decline in swallowing function after 2 years was associated with the male gender (odds ratio [ORs]: 0.772; 95% confidence interval [CIs]: 0.615–0.969), age ≥ 81 years (presence; ORs: 1.523; 95% CIs: 1.224–1.895), support/care-need certification (presence; ORs: 1.815; 95% CIs: 1.361–2.394), periodontal pocket depth (PPD) ≥ 4 mm (presence; ORs: 1.469; 95% CIs: 1.163–1.856), difficulty in biting hard food (yes; ORs: 1.439; 95% CIs: 1.145–1.808), choking on tea and water (yes; ORs: 2.543; 95% CIs: 2.025–3.193), and dry mouth (yes; ORs: 1.316; 95% CIs: 1.052–1.646) at baseline. Therefore, the dental checkup items associated with a decline in swallowing function after 2 years were a PPD ≥ 4 mm, difficulty in biting hard food, choking on tea and water, and dry mouth. PPD status and confirming to the self-administered questionnaire about biting, choking, and dry mouth may be useful in predicting future decline in swallowing function.
Civil Integrated Management (CIM) for Advanced Level Applications to Transportation Infrastructure: A State-of-the-Art Review
Authors: Taheri Ali , Sobanjo John
Published: May 2024

The recent rise in the applications of advanced technologies in the sustainable design and construction of transportation infrastructure demands an appropriate medium for their integration and utilization. The relatively new concept of Civil Integrated Management (CIM) is such a medium; it enhances the development of digital twins for infrastructure and also embodies various practices and tools, including the collection, organization, and data-management techniques of digital data for transportation infrastructure projects. This paper presents a comprehensive analysis of advanced CIM tools and technologies and categorizes its findings into the following research topics: application of advanced surveying methods (Advanced Surveying); geospatial analysis tools for project planning (Geospatial Analysis); multidimensional virtual design models (nD Modeling); Integrated Geospatial and Building Information Modeling (GeoBIM); and transportation infrastructure maintenance and rehabilitation planning (Asset Management). Despite challenges such as modeling complexity, technology investment, and data security, the integration of GIS, BIM, and artificial intelligence within asset-management systems hold the potential to improve infrastructure’s structural integrity and long-term performance through automated monitoring, analysis, and predictive maintenance during its lifetime.
Thought to Be Extinct, but Still Alive Today: The Miocene Genus Primascena Klimaszewsi, 1997 (Hemiptera: Psyllidae) in the Light of Two Extant Species from Brazil
Authors: Burckhardt Daniel , Queiroz Dalva L.
Published: May 2024

Fossils can document the morphological diversification through time and date lineages, providing relevant characters are preserved. Primascena Klimaszewsi, 1997 was erected for P. subita Klimaszewsi, 1997 on the basis of a single, partly damaged male from Dominican amber. Originally assigned to Rhinocolidae: Paurocephalinae, the genus was subsequently transferred to Psyllidae: Aphalaroidinae. Recently, two undescribed species resembling the fossil species were discovered in Brazil (Mato Grosso do Sul), allowing a detailed morphological study of adults and immatures. Based on the morphological study, a revised diagnosis of the genus is provided, including the previously unknown female and fifth instar immatures. Primascena subita is redescribed and P. empsycha n. spec. and P. ruprechtiae n. spec. are formally described and illustrated. An identification key is provided for the species of Primascena. A cladistic morphological analysis supports the placement of the two new species in Primascena, and of this genus in the Aphalaroidinae. It is sister to all but Aphalaroida, though with little support. The two Brazilian species develop on Ruprechtia spp. (Polygonaceae: Eriogonoideae), an unusual psyllid host. Immatures of P. ruprechtiae are free-living on the lower leaf face and do not induce galls.
Rheological Behavior Features of Feedstocks with a Two-Component Wax–Polyolefin Binder Compared to Analogs Based on Polyoxymethylene
Authors: Muranov Alexander N. , Lysenko Viktor R. , Kocharov Maxim A.
Published: May 2024

Despite the large number of studies devoted to different compositions of polymer binders for PIM technology, the actual task is still a comparative analysis of the properties of different types of binders to determine their advantages and disadvantages and optimize the compositions used. In this regard, this study aims at the identification and comparative analysis of the rheological properties of the most demanded feedstocks with binders based on polyoxymethylene and a wax–polyolefin mixture under the condition of using identical steel powder filler. The rate of change in the volume fraction of the liquid phase of the binder in the compared feedstocks with temperature change was determined by the calculation–experimental method. As shown, the temperature dependence of the viscosity of feedstocks with a binder based on a polymer blend depends on factors with variable power, i.e., the viscosity change with temperature occurs by different mechanisms with their relaxation spectra. Thus, the principle of temperature–time superposition for feedstocks with multicomponent binders is not applicable, and the study of the viscosity of such materials should involve a wide range of shear rates and temperatures using experimental methods. Capillary rheometry was used to measure the flow curves of feedstocks based on polyoxymethylene and wax–polyolefin binders. The analysis of flow curves of feedstocks showed that feedstocks with a binder of solution–thermal type of debinding have significantly lower viscosity, which is an advantage for molding thin-walled products. However, their difference of 1.5 times sensitivity to the shear rate gradient leads to their lower resistance to “jets” and liquation of components because of shear rate gradients when molding products with elements of different cross-sectional areas.
Past and Future Impacts of the Relative Sea Level Rise on the Seafront of Ancient Delos (Cyclades, Greece) and Flooding Scenarios by 2150
Authors: Mourtzas Nikos , Kolaiti Eleni
Published: May 2024

Sea level rise due to global warming is a continuing and, disappointingly, accelerating process which has already affected and will further impact coastal lowlands and the social and economic activities in these areas. Delos Island, situated in the middle of the Cyclades in the Aegean Sea, was considered the most sacred of all islands in ancient Greek culture and was a trading hub for the entire eastern Mediterranean. Uninhabited since the 7th century AD, and consistently the focus of research and touristic attention, the island is designated as an archaeological site and inscribed on the UNESCO World Heritage List. Previous studies on the relative sea level (rsl) changes suggest a steadily rising rsl during the last 6300 years, starting from a sea level of −4.80 ± 0.20 m in the Late Neolithic. The seafront of the ancient city of Delos is subject to the effects of rsl rise, which have caused significant coastline retreat and exposure to the northerly winds and waves, whereas parts of the coastal lowland, where the remains of the ancient city lie, are inundated, forming extended wetlands. The future impacts of rsl rise on the seafront of ancient Delos are illustrated on very-high-resolution digital surface models, evaluating both the flooding risk under different climatic projections, as provided by the IPCC AR6 report, and the ongoing land subsidence, as recorded by GNSS data. An rsl rise ranging from 87 cm (SSP1-2.6 scenario) to 148 cm (SSP5-8.5 scenario) is anticipated by 2150, requiring both resilience strategies and adaptation solutions as well as mitigation policies to cope with the effects of climate change.
Ship Bridge OOW Activity Status Detection Using Wi-Fi Beamforming Feedback Information
Authors: Chen Mengda , Zhang Liang , Liu Yang , Zhang Yifan , Liu Cheng , Chen Mozi
Published: May 2024

Officers on Watch (OOWs) of the ship’s bridge play a vital role in maritime navigation safety, monitoring the ship’s navigational status, and ensuring maritime safety. The status of inactive watch officers, such as fatigued driving and negligence on lookout, is one of the main causes of accidents. Intelligent technology for real-time perception and state evaluation of ship OOWs significantly reduces accidents caused by human factors. The traditional computer vision method is difficult to adapt to the complex environment of a ship bridge, and carries strong privacy risks. With the development of Internet of Things technology, sensing technology based on ubiquitous Wi-Fi devices provides a new way to accurately monitor the status of ship OOWs. In this paper, we use commercial off-the-shelf (COTS) Wi-Fi devices to propose a ship driving activity state detection method based on beamforming feedback information (BFI). Using wireless sensing data to sense the number of OOWs and their driving behavior realizes low-cost and high-precision detection of the behavioral status of the ship’s bridge watchkeeper. Experiments were conducted in a ship-driving simulation laboratory and on a real-world Yangtze River cruise ship. The experimental results demonstrate that our proposed method achieves 92.4% and 98.1% accuracy for tracking active status and estimating the number of OOWs, respectively.
Rice Weevil (Sitophilus oryzae L.) Gut Bacteria Inhibit Growth of Aspergillus flavus and Degrade Aflatoxin B1
Authors: Al-Saadi Haneen Abdullah , Al-Sadi Abdullah Mohammed , Al-Wahaibi Ali , Al-Raeesi Ali , Al-Kindi Mohamed , Soundra Pandian Sathish Babu , Al-Harrasi Majida Mohammed Ali , Al-Mahmooli Issa Hashil , Velazhahan Rethinasamy
Published: May 2024

In this study, bacteria residing in the gut of the rice weevils (Sitophilus oryzae L.) (Coleoptera: Curculionidae) feeding on aflatoxin-contaminated corn kernels were isolated and evaluated for their ability to suppress Aspergillus flavus and to remove/degrade aflatoxin B1 (AFB1). Four morphologically distinct S. oryzae gut-associated bacterial isolates were isolated and identified as Bacillus subtilis (RWGB1), Bacillus oceanisediminis (RWGB2), Bacillus firmus (RWGB3), and Pseudomonas aeruginosa (RWGB4) based on 16S rRNA gene sequence analysis. These bacterial isolates inhibited A. flavus growth in the dual culture assay and induced morphological deformities in the fungal hyphae, as confirmed by scanning electron microscopy. All four bacterial isolates were capable of removing AFB1 from the nutrient broth medium. In addition, culture supernatants of these bacterial isolates degraded AFB1, and the degradation of toxin molecules was confirmed by liquid chromatography-mass spectrometry. The bacterial isolates, B. subtilis RWGB1, B. oceanisediminis RWGB2, and P. aeruginosa RWGB4, were capable of producing antifungal volatile organic compounds that inhibited A. flavus growth. These results suggest that the bacterial isolates from S. oryzae gut have the potential to bind and/or degrade AFB1. Further research on their application in the food and feed industries could enhance the safety of food and feed production.
Investing in US Timberland Companies
Authors: Francis Jack Clark , Zhang Ge
Published: May 2024

Are common stocks issued by timberland companies a good investment? Portfolios of large US timberland corporations are compared to simultaneous investments in a diversified US common stock index. Over a 20-year sample period it turns out that the US timberland corporations, on average, perform about as well as the highly diversified US stock market index. It is surprising that the timberland companies do not outperform the stock market indexes because, in order to encourage tree planting, the US Congress has almost completely exempted timberland companies from paying federal income taxes. Furthermore, it is scientifically impossible to assess the value of the large amounts of photosynthesis that the timberland companies produce. As a result of these two ambiguities, it is difficult to state decisively that the timberland companies are better investments than a diversified portfolio of common stocks. However, valuing timberland companies is more practical than endeavoring to value the trees directly.
Synthesis and Antibacterial Studies of a New Au(III) Complex with 6-Methyl-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One
Authors: Marinova Petya , Burdzhiev Nikola , Blazheva Denica , Slavchev Aleksandar
Published: May 2024

This article describes the synthesis of a new metal complex using 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one. The compound was analyzed using several methods, including determining its melting point and employing UV-Vis, IR, ATR, 1H NMR, HSQC, and Raman spectroscopy for the free ligand. The metal complex was formed by combining aqueous solutions of metal salts with the ligand dissolved in DMSO and water, along with NaOH in a metal-to-ligand-to-base ratio of 1:4:2. The NMR signals of the ligand were assigned using 1H-1H COSY, DEPT-135, HMBC, and HMQC spectra. Furthermore, the compound’s antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeasts, was assessed.
Optimal Routing and Scheduling of Flag State Control Officers in Maritime Transportation
Authors: Qiao Xizi , Yang Ying , Guo Yu , Jin Yong , Wang Shuaian
Published: May 2024

Maritime transportation plays a pivotal role in the global merchandise trade. To improve maritime safety and protect the environment, every state must effectively control ships flying its flag, which is called flag state control (FSC). However, the existing FSC system is so inefficient that it cannot perform its intended function. In this study, we adopt an optimization method to tackle this problem by constructing an integer programming (IP) model to solve the FSC officer routing and scheduling problem, which aims to maximize the total weight of inspected ships with limited budget and human resources. Then we prove that the IP model can be reformulated into a partially relaxed IP model with the guarantee of the result optimality. Finally, we perform a case study using the Hong Kong port as an example. The results show that our model can be solved to optimality within one second at different scales of the problem, with the ship number ranging from 20 to 1000. Furthermore, our study can be extended by considering the arrangement of working timetables with finer granularity and the fatigue level of personnel.
Reliability Estimation in Stress Strength for Generalized Rayleigh Distribution Using a Lower Record Ranked Set Sampling Scheme
Authors: Dong Yinuo , Gui Wenhao
Published: May 2024

This paper explores the likelihood and Bayesian estimation of the stress–strength reliability parameter (R) based on a lower record ranked set sampling scheme from the generalized Rayleigh distribution. Maximum likelihood and Bayesian estimators as well as confidence intervals of R are derived and their properties are studied. Furthermore, two parametric bootstrap confidence intervals are introduced in the paper. A comparative simulation study is conducted to assess the effectiveness of these four confidence interval methodologies in estimating R. The application of the methods is demonstrated using real data on fiber strength to showcase their practicability and relevance in the industry.
Identification and Free Radical Scavenging Activity of Oligopeptides from Mixed-Distillate Fermented Baijiu Grains and Soy Sauce Residue
Authors: Zhao Yunhao , Liu Xiangyue , Zhang Sijie , Wang Zhengwei , Tian Shanlin , Wu Qiang
Published: May 2024

This study aimed to explore the potential antioxidant activity and mechanism of oligopeptides from sauce-aroma Baijiu. The oligopeptides of Val-Leu-Pro-Phe (VLPF), Pro-Leu-Phe (PLF), Val-Gly-Phe-Cys (VGFC), Leu-Tyr-Pro (LYP), Leu-Pro-Phe (LPF), and Phe-Thr-Phe (FTF) were identified by liquid chromatography–mass spectrometry (LC–MS) from the mixed-distillate of Baijiu fermented grains and soy sauce residue (MDFS). The antioxidant mechanism of these oligopeptides on scavenging DPPH•, ABTS•+, and hydroxide radicals was investigated, respectively. Among them, VGFC had the strongest potential antioxidant activity, which was responsible for its hydrogen bonds with these radicals with high affinity. The binding energies between VGFC and these radicals were −1.26 kcal/mol, −1.33 kcal/mol, and −1.93 kcal/mol, respectively. Additionally, free radicals prefer to bind the oligopeptide composed of hydrophobic amino acid residues such as Leu, Val, Phe, and Pro, thus being scavenged for exerting antioxidant activity. It provided a new idea for the development and utilization of bioactive oligopeptides in sauce-aroma Baijiu.
Bioactive Phyto-Compounds with Antimicrobial Effects and AI: Results of a Desk Research Study
Authors: Mihaylova Silviya , Tsvetkova Antoaneta , Georgieva Emiliya , Vankova Desislava
Published: May 2024

Resistance of microorganisms to antibiotics represents a formidable global challenge, manifesting in intricate public health ramifications including escalated mortality rates and augmented healthcare costs. The current efforts to manage antimicrobial resistance (AMR) are limited mainly to the standard therapeutic approaches. The aim of this study is to present and analyze the role of artificial intelligence (AI) in the search for new phyto-compounds and novel interactions with antimicrobial effects. The ambition of the current research study is to support researchers by providing summarized information and ideas for future research in the battle with AMR. Inevitably, the AI role in healthcare is growing exponentially. The reviewed AI models reveal new data on essential oils (EOs) as potential therapeutic agents. In terms of antibacterial activity, EOs show activity against MDR bacteria, reduce resistance by sensitizing bacteria to the action of antibiotics, and improve therapeutic efficiency when combined with antibiotics. AI models can also serve for the detailed study of other therapeutic applications of EOs such as respiratory diseases, immune diseases, neurodegenerative diseases, and oncological diseases. The last 5 years have seen an increasing application of AI in the search for potential plant sources to control AMR. For the time being, the application of machine-learning (ML) models is greater in the studies of EOs. Future attention of research teams may also be directed toward a more efficient search for plant antimicrobial peptides (PAMPs). Of course, investments in this direction are a necessary preface, but the excitement of new possibilities should not override the role of human intelligence in directing research processes. In this report, tradition meets innovation to address the “silent pandemic” of AMR.
A Systematical Study on Bands and Defects of CsBX3 (B = Pb, Sn, Ge, X = Cl, Br, I) Perovskite Based on First Principles
Authors: Zhang Chunqian , Wang Hao , Huang Wenqi , Zuo Yuhua , Cheng Jin
Published: May 2024

Metal halide perovskites have attracted considerable attention as novel optoelectronic materials for their excellent optical and electrical properties. Inorganic perovskites (CsPbX3, X = Cl, Br, I) are now viable alternative candidates for third-generation photovoltaic technology because of their high photoelectric conversion efficiency, high carrier mobility, good defect tolerance, simple preparation method and many other advantages. However, the toxicity of lead is problematic for practical implementation. Thus, the fabrication of lead-free perovskite materials and devices has been actively conducted. In this work, the energy band and photoelectric properties of inorganic perovskites CsBX3 (B = Pb, Sn, Ge, X = Cl, Br, I) have been investigated with the first principles calculation, and the possible defect energy levels and their formation energies in different components, in particular, have been systematically studied. The advantages and disadvantages of Sn and Ge as replacement elements for Pb have been demonstrated from the perspective of defects. This study provides an important basis for the study of the properties and applications of lead-free perovskites.
Synthesis, X-ray Studies and Photophysical Properties of Iridium(III) Complexes Incorporating Functionalized 2,2′:6′,2″ Terpyridines and 2,6-Bis(thiazol-2-yl)pyridines
Authors: Zowiślok Bartosz , Świtlicka Anna , Maroń Anna , Siwy Mariola
Published: May 2024

A series of iridium(III) triimine complexes incorporating 2,2′:6′,2″-terpyridine (terpy) and 2,6-bis(thiazol-2-yl)pyridine (dtpy) derivatives were successfully designed and synthesized to investigate the impact of the peripheral rings (pyridine, thiazole) and substituents (thiophene, bithiophene, EDOT) attached to the triimine skeleton on their photophysical properties. The Ir(III) complexes were fully characterized using IR, 1H, elemental analysis and single crystal X-ray analysis. Their thermal properties were evaluated using TGA measurements. Photoluminescence spectra of [IrCl3L1–6] were investigated in solution at 298 and 77 K. The experimental studies were accompanied by DFT/TDDFT calculations. The photophysical properties of the synthesized triimine ligands and Ir(III) complexes were studied in detail by electronic absorption and emission. In solution, they exhibited photoluminescence quantum yields ranging from 1.27% to 5.30% depending on the chemical structure. The experimental research included DFT/TDDFT calculations. The photophysical properties of the synthesized triimine ligands and Ir(III) complexes were conducted using electronic absorption and emission techniques. In solution, they displayed photoluminescence quantum yields ranging from 1.27% to 5.30% depending on the chemical structure.
Population Pharmacokinetics of Dasatinib in Healthy Subjects
Authors: Hassouneh Walaa B. , Al-Ghazawi Mutasim A. , Saleh Mohammad I. , Najib Naji
Published: May 2024

Background and Objectives: Dasatinib is one of the tyrosine kinase inhibitors. The main use of these agents is inhibition of cancerous cell proliferation. The therapeutic importance of tyrosine kinase inhibitors raises the necessity of many types of investigations, especially the pharmacokinetic analysis of these drugs in humans. This analysis, along with other investigations and clinical research, will contribute to the overall knowledge of the drug. This study focused on the population pharmacokinetics of dasatinib. The objective of the study was to investigate the sources of the variability of dasatinib in a population pharmacokinetics study in healthy participants. Methods: We utilized 4180 plasma observations from 110 subjects who were administered SPRYCEL® on two separate occasions under fasting conditions; data from 20% of the subjects (22 subjects) were extracted for the purpose of internal model evaluation and data from 88 subjects were used in modeling. The model was evaluated by visual predictive check of three different datasets. A two-compartmental model with first order absorption and transit compartment was considered the simplest base model to describe the data based on the corrected Bayesian information criterion evaluation. Covariates were tested through conditional sampling for the stepwise approach-screening procedure in Monolix 2020R1 version. Conditional sampling for the stepwise approach was used to include the correlated covariates within the base model in the forward inclusion step and then to eliminate them backwardly to ensure that the key covariates were kept in the model at the final stage. Results: The effect of body mass index on the absorption rate constant was considered as significant covariate in the final established model. Visual predictive check for simulations, 20% of the original dataset (internal dataset) and an external dataset demonstrated the appropriateness of the final model. Conclusions: Population pharmacokinetic modeling was performed to describe dasatinib pharmacokinetics in healthy subjects. Body mass index was considered as a factor that might be used in the future along with studies on patients to adjust the dosing regimens. Key Points: Dasatinib is classified as a highly variable drug; this variability was demonstrated in the study by the effect of body mass index on the absorption rate constant.
Complex Emulsions as an Innovative Pharmaceutical Dosage form in Addressing the Issues of Multi-Drug Therapy and Polypharmacy Challenges
Authors: Yandrapalli Naresh
Published: May 2024

This review explores the intersection of microfluidic technology and complex emulsion development as a promising solution to the challenges of formulations in multi-drug therapy (MDT) and polypharmacy. The convergence of microfluidic technology and complex emulsion fabrication could herald a transformative era in multi-drug delivery systems, directly confronting the prevalent challenges of polypharmacy. Microfluidics, with its unparalleled precision in droplet formation, empowers the encapsulation of multiple drugs within singular emulsion particles. The ability to engineer emulsions with tailored properties—such as size, composition, and release kinetics—enables the creation of highly efficient drug delivery vehicles. Thus, this innovative approach not only simplifies medication regimens by significantly reducing the number of necessary doses but also minimizes the pill burden and associated treatment termination—issues associated with polypharmacy. It is important to bring forth the opportunities and challenges of this synergy between microfluidic-driven complex emulsions and multi-drug therapy poses. Together, they not only offer a sophisticated method for addressing the intricacies of delivering multiple drugs but also align with broader healthcare objectives of enhancing treatment outcomes, patient safety, and quality of life, underscoring the importance of dosage form innovations in tackling the multifaceted challenges of modern pharmacotherapy.
Focused Ultrasound-Mediated Disruption of the Blood–Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington’s Disease
Authors: Owusu-Yaw Bernie S. , Zhang Yongzhi , Garrett Lilyan , Yao Alvin , Shing Kai , Batista Ana Rita , Sena-Esteves Miguel , Upadhyay Jaymin , Kegel-Gleason Kimberly , Todd Nick
Published: May 2024

Huntington’s disease (HD) is a monogenic neurodegenerative disorder caused by a cytosine–adenine–guanine (CAG) trinucleotide repeat expansion in the HTT gene. There are no cures for HD, but the genetic basis of this disorder makes gene therapy a viable approach. Adeno-associated virus (AAV)-miRNA-based therapies have been demonstrated to be effective in lowering HTT mRNA; however, the blood–brain barrier (BBB) poses a significant challenge for gene delivery to the brain. Delivery strategies include direct injections into the central nervous system, which are invasive and can result in poor diffusion of viral particles through the brain parenchyma. Focused ultrasound (FUS) is an alternative approach that can be used to non-invasively deliver AAVs by temporarily disrupting the BBB. Here, we investigate FUS-mediated delivery of a single-stranded AAV9 bearing a cDNA for GFP in 2-month-old wild-type mice and the zQ175 HD mouse model at 2-, 6-, and 12-months. FUS treatment improved AAV9 delivery for all mouse groups. The delivery efficacy was similar for all WT and HD groups, with the exception of the zQ175 12-month cohort, where we observed decreased GFP expression. Astrocytosis did not increase after FUS treatment, even within the zQ175 12-month group exhibiting higher baseline levels of GFAP expression. These findings demonstrate that FUS can be used to non-invasively deliver an AAV9-based gene therapy to targeted brain regions in a mouse model of Huntington’s disease.
Tunable Near-Infrared Transparent Bands Based on Cascaded Fabry–Perot Cavities Containing Phase Change Materials
Authors: She Yuchun , Zhong Kaichan , Tu Manni , Xiao Shuyuan , Chen Zhanxu , An Yuehua , Liu Dejun , Wu Feng
Published: May 2024

In this paper, we construct a near-infrared Fabry–Perot cavity composed of two sodium (Na) layers and an antimony trisulfide (Sb2S3) layer. By cascading two Fabry–Perot cavities, the transmittance peak splits into two transmittance peaks due to the coupling between two Fabry–Perot modes. We utilize a coupled oscillator model to describe the mode coupling and obtain a Rabi splitting of 60.0 meV. By cascading four Fabry–Perot cavities, the transmittance peak splits into four transmittance peaks, leading to a near-infrared transparent band. The near-infrared transparent band can be flexibly tuned by the crystalline fraction of the Sb2S3 layers. In addition, the effects of the layer thickness and incident angle on the near-infrared transparent band and the mode coupling are investigated. As the thickness of the Na layer increases, the coupling strength between the Fabry–Perot modes becomes weaker, leading to a narrower transparent band. As the thickness of the Sb2S3 layer increases, the round-trip propagating of the Sb2S3 layer increases, leading to the redshift of the transparent band. As the incident angle increases, the round-trip propagating of the Sb2S3 layer decreases, leading to the blueshift of the transparent band. This work not only provides a viable route to achieving tunable near-infrared transparent bands, but also possesses potential applications in high-performance display, filtering, and sensing.
Performance Analysis of Six Electro-Optical Crystals in a High-Bandwidth Traveling Wave Mach-Zehnder Light Modulator
Authors: Ataei Abtin , McManamon Paul , Sarangan Andrew
Published: May 2024

In this study, a traveling wave Mach-Zehnder intensity modulator (TW-MZM) was designed and optimized for six different electro-optical (EO) crystals: lithium niobate (LNB), potassium niobate (KNB), lithium titanate (LTO), beta barium borate (BBO), cadmium telluride (CdTe), and indium phosphide (InP). The performance of each EO crystal, including optical and radio frequency (RF) loss, applied voltage, and modulation bandwidth, was estimated and compared. The results suggest that, in theory, KNB, LTO, BBO, and CdTe have the potential to outperform LNB. However, it should be noted that the loss associated with KNB and LTO is comparable to that of LNB. The findings demonstrated that BBO and CdTe exhibit a modulation bandwidth exceeding 100 GHz and demonstrate the lowest loss among the considered crystals based on the assumed geometry.
An Experimental Study on the Flash Boiling Characteristics of Liquid Ammonia Spray in a Constant Volume Chamber under High Injection Pressure
Authors: He Haibin , Wu Jie , Wang Lei , Lou Hua , Li Songfeng , Huang Lvmeng , Chen Zhanming
Published: May 2024

The spray characteristics of liquid ammonia under various ambient pressures and temperatures were analyzed in a constant volume chamber to cover a wide range of superheat degrees. The injection pressure was set as 70 and 80 MPa with ambient pressure ranging from 0.2 to 4 MPa. The ambient temperature was 500 K. The results showed that the higher the injection pressure, the greater the kinetic energy obtained. The droplet fragmentation was enhanced, and the phenomenon of gradual separation of the gas–liquid region occurred with increasing injection pressure. Under flash boiling spray conditions, the spray developed faster than non-flash boiling and transition flash boiling spray under the same injection pressure. In addition, the flash boiling spray tip penetration of the gas and liquid increased more than that of cold spray, and the fluctuation of the late stage of the injection was relatively large. Therefore, the injection pressure has a greater effect on the spray tip penetration of flash boiling spray. Moreover, ambient pressure greatly influences the flare flash boiling spray. The spray resistance phenomenon was found during the spray development in the flare flash boiling condition. With the increase in ambient pressure, the spray tip penetration of flash boiling spray decreases due to the reduction in the pressure difference inside and outside the spray hole and the restriction of ambient gas. Meanwhile, owing to the low ambient pressure and ambient density, the liquid penetration in the initial phase of the flare flash boiling spray will be abnormally shorter than that of the non-flash boiling spray.
The Impact of Installation Angle on the Wind Load of Solar Photovoltaic Panels
Authors: Jiang Hai-Bing , Huang Hui-Fan , Zhang Yu-Liang , Xu Xiao-Wei , Zhao Yan-Juan
Published: May 2024

In order to explore the wind load characteristics acting on solar photovoltaic panels under extreme severe weather conditions, based on the Shear Stress Transport (SST) κ-ω turbulence model, numerical calculations of three-dimensional incompressible viscous steady flow were performed for four installation angles and two extreme wind directions of the solar photovoltaic panels. The wind load characteristics on both sides of the photovoltaic panels were obtained, and the vortex structure characteristics were analyzed using the Q criterion. The results indicate that, under different installation angles, the windward side pressure of the solar photovoltaic panel is generally higher than the leeward side. The leeward side is prone to forming larger vortices, increasing the fatigue and damage risk of the material, which significantly impacts the solar photovoltaic panel. As the installation angle increases, the windward side pressure of the solar photovoltaic panel also gradually increases. Therefore, optimal installation methods include installing the panel facing the wind at angles of 30° and 45°, or installing it facing away from the wind at a 60° angle, to minimize the impact of wind load on the solar photovoltaic panel.
Development and Properties of Recycled Biomass Fly Ashes Modified Mortars
Authors: Hubert Julien , Grigoletto Sophie , Michel Frédéric , Zhao Zengfeng , Courard Luc
Published: May 2024

The production of biomass fly ash has been increasing every year in Europe, reaching 5.5 million tons in 2020. Fly ash produced by burning biomass is not yet accepted in the standards as a substitute material for cement in mortar and concrete. In a first approach, the substitution limit of biomass ash is determined by comparing the mechanical strengths (among others, compressive strength), fresh state properties and hardened properties of mortars produced with fly ash with those of mortars produced with coal fly ash (EN 450-1 and ASTM C618). Masonry and rendering mortars have been designed with different substitution rates of fly ashes from wood combustion in thermal power plants. Although there is an overall decrease in performance, mortars made with biomass ash retain properties that make them suitable for use in masonry (loss of 13% compressive strength for masonry mortars with 10% substitution rate after 90 days) or rendering (loss of 20% compressive strength for rendering mortars with 10% substitution rate after 90 days). Water absorption and porosity (24.1 and 23.7% for masonry and rendering mortars, respectively) are, however, not significantly modified, which potentially contributes to good durability properties.
The World Is the Road to God: The Encyclical Laudato Si’ and the “Ecological” Vision of Pope Francis
Authors: Tarzia Fabio , Ilardi Emiliano
Published: May 2024

Today, the response to the consequences of present and future environmental catastrophes tends to take three forms: one purely technological-productive coming from the alliance between States and the Market; another one, which is essentially movementist, is confusedly fragmented into initiatives, often contradictory to each other, without having a strong ideological–political vision at its base; and the third one refers to apocalyptic or posthuman messianisms of a philosophical–religious nature. None of the three forms envisions a radical transformation of the current political–economic system. In this context, the voice of the Catholic Church emerges strongly to denounce the systemic reasons for the environmental disaster and at the same time to oppose the current system another system, centered on alternative assumptions. This article will analyze the encyclical Laudato Si’ (2015), which, sometimes mistaken for a simple text on Christian ecology, should actually be interpreted as a manifesto for a new world, based on the idea of a total anthropological and socio-political revolution. The analysis of the Encyclical is intended to highlight the historical–theological foundations and the ability to adapt some of the cornerstones of Catholicism (in particular of the Franciscan and Jesuit matrix) to the resolution of the current ecological emergency.
From Singing “Out-of-Tone” to Creating Contextualized Cantonese Contemporary Worship Songs: Hong Kong in the Decentralization of Chinese Christianity
Authors: Hung Shin Fung
Published: May 2024

For over a century, Hong Kong Christians have sung Chinese hymns in an “out-of-tone” manner. Lyrics in traditional hymnals were translated or written to be sung in Mandarin, the national language, but most locals speak Cantonese, another Sinitic and tonal language. Singing goes “out-of-tone” when Mandarin hymns are sung in Cantonese, which often causes meaning distortions. Why did Hong Kong Christians accept this practice? How did they move from singing “out-of-tone” to creating contextualized Cantonese contemporary worship songs? What does this process reveal about the evolution of Chinese Christianity? From a Hong Kong-centered perspective, this article reconstructs the city’s hymnological development. I consider the creation of national Mandarin hymnals during Republican China as producing a nationalistic Mainland-centric and Mandarin-centric Chinese Christianity. Being on the periphery, Hong Kong Christians did not have the resources to develop their own hymns and thus continued to worship “out-of-tone”. With the decline of the old Chinese Christian center of Shanghai, the growth of Cantonese culture and Hongkonger identity, and the influence of Western pop and Christian music, local Christians began to create Cantonese contemporary worship songs. This hymnological contextualization reflects and contributes to not only the decolonization but, more importantly, the decentralization of Chinese Christianity.
Some Results on Bivariate Squared Maximum Sharpe Ratio
Authors: Mousavi Samane Al-sadat , Dolati Ali , Dastbaravarde Ali
Published: May 2024

The Sharpe ratio is a widely used tool for assessing investment strategy performance. An essential part of investing involves creating an appropriate portfolio by determining the optimal weights for desired assets. Before constructing a portfolio, selecting a set of investment opportunities is crucial. In the absence of a risk-free asset, investment opportunities can be identified based on the Sharpe ratios of risky assets and their correlation. The maximum squared Sharpe ratio serves as a useful metric that summarizes the performance of an investment opportunity in a single value, considering the Sharpe ratios of assets and their correlation coefficients. However, the assumption of a normal distribution in asset returns, as implied by the Sharpe ratio and related metrics, may not always hold in practice. Non-normal returns with a non-linear dependence structure can result in an overestimation or underestimation of these metrics. Copula functions are commonly utilized to address non-normal dependence structures. This study examines the impact of asset dependence on the squared maximum Sharpe ratio using copulas and proposes a copula-based approach to tackle the estimation issue. The performance of the proposed estimator is illustrated through simulation and real-data analysis.
Monitoring Long-Term Land Cover Change in Central Yakutia Using Sparse Time Series Landsat Data
Authors: Lee Yeji , Kim Su-Young , Jung Yoon Taek , Park Sang-Eun
Published: May 2024

Recently, as global climate change and local disturbances such as wildfires continue, long- and short-term changes in the high-latitude vegetation systems have been observed in various studies. Although remote sensing technology using optical satellites has been widely used in understanding vegetation dynamics in high-latitude areas, there has been limited understanding of various landscape changes at different spatiotemporal scales, their mutual relationships, and overall long-term landscape changes. The objective of this study is to devise a change monitoring strategy that can effectively observe landscape changes at different spatiotemporal scales in the boreal ecosystems from temporally sparse time series remote sensing data. We presented a new post-classification-based change analysis scheme and applied it to time series Landsat data for the central Yakutian study area. Spectral variability between time series data has been a major problem in the analysis of changes that make it difficult to distinguish long- and short-term land cover changes from seasonal growth activities. To address this issue effectively, two ideas in the time series classification, such as the stepwise classification and the lateral stacking strategies were implemented in the classification process. The proposed classification results showed consistently higher overall accuracies of more than 90% obtained in all classes throughout the study period. The temporal classification results revealed the distinct spatial and temporal patterns of the land cover changes in central Yakutia. The spatiotemporal distribution of the short-term class illustrated that the ecosystem disturbance caused by fire could be affected by local thermal and hydrological conditions of the active layer as well as climatic conditions. On the other hand, the long-term class changes revealed land cover trajectories that could not be explained by monotonic increase or decrease. To characterize the long-term land cover change patterns, we applied a piecewise linear model with two line segments to areal class changes. During the former half of the study period, which corresponds to the 2000s, the areal expansion of lakes on the eastern Lena River terrace was the dominant feature of the land cover change. On the other hand, the land cover changes in the latter half of the study period, which corresponds to the 2010s, exhibited that lake area decreased, particularly in the thermokarst lowlands close to the Lena and Aldan rivers. In this area, significant forest decline can also be identified during the 2010s.