bluuebunny/crossref_metadata_2025 huggingface dataset:
Harnessing the Power of Generative AI to Support ALL Learners
Authors: Evmenova Anya S. , Borup Jered , Shin Joan Kang
Published: May 2024

While generative AI such as ChatGPT has important drawbacks, it can potentially unlock new types of learning and support – specially for English learners and students with disabilities – by facilitating teachers’ Universal Design for Learning (UDL) efforts. As generative AI is quickly becoming an integral part of our lives (e.g., being incorporated into existing tools such as Google products), teachers will need to decide how they can use and benefit from this new technology. Our analysis of data collected during a summer teacher institute found that in Summer 2023 the majority of teachers had never used generative AI and were evenly split on whether it was a “friend” or “foe” in their teaching efforts. Overall, 43% of teachers reported, “ChatGPT and other generative AI will help make instruction more accessible for ALL learners,” while 32% of teachers were “undecided” indicating an opportunity to improve teacher perceptions. In this article we discuss strategies for using generative AI for improving UDL to benefit ALL learners brainstormed by the teachers. Practical implications for multilingual learners are discussed.
Impact of Ohmic Heating and Ultrasound Pretreatments on Oil Absorption and Other Quality Parameters of Fried Potato
Authors: Sari Ferda , Incedayi Bige , Turkmen Erol Nihal , Akpinar Pınar , Copur Omer Utku
Published: May 2024

In this study, the effect of pretreatments ((hot water blanching (HWB), ultrasound (US) and ohmic heating (OH)) on reducing the oil absorption of potato during frying and the changes in the quality parameters of the product ((total polyphenol (TP), in vitro digestion, total flavonoid (TF), antioxidant capacity (AC), chlorogenic acid (CA), textural and sensorial properties)) were investigated. The pretreatments applied significantly affected oil absorption and quality parameters of fried potato. The oil content of fried potatoes ranged from 26.06 to 32.01% depending on the pretreatment. OH-pretreated potato had the highest content of TP (41.27 mg GAE/100 g dry matter-DM), TF (32.89 mg RE/100 g DM) and CA (1.72 mg/100 g DM). However, there was no significant difference between the pretreatments in terms of bioaccessibility of polyphenols at the end of digestion. Also, AC value of fried potato pretreated by OH (124.13 mmol AAE/100 g DM) was higher compared to that of fresh potato (83.91 mmol AAE/100 g DM), but other two pretreatments caused a decrease in AC. The highest hardness was observed in HWB-treated potato strips. OH-treated potato had the best color parameters. Sensory data indicated that US-pretreated potato had the highest sensory scores followed by OH- and HWB-pretreated ones, respectively. Consequently, based on the above comprehensive quality evaluation, it can be suggested that OH pretreatment is a better choice for preparing deep fried potato.
Multiparametric approach with synthetic MR imaging for diagnosing salivary gland lesions
Authors: Takumi Koji , Nakanosono Ryota , Nagano Hiroaki , Hakamada Hiroto , Kanzaki Fumiko , Kamimura Kiyohisa , Nakajo Masatoyo , Eizuru Yukari , Nagano Hiromi , Yoshiura Takashi
Published: May 2024

Purpose

To determine whether synthetic MR imaging can distinguish between benign and malignant salivary gland lesions.

Methods

The study population included 44 patients with 33 benign and 11 malignant salivary gland lesions. All MR imaging was obtained using a 3 Tesla system. The QRAPMASTER pulse sequence was used to acquire images with four TI values and two TE values, from which quantitative images of T1 and T2 relaxation times and proton density (PD) were generated. The Mann–Whitney U test was used to compare T1, T2, PD, and ADC values among the subtypes of salivary gland lesions. ROC analysis was used to evaluate diagnostic capability between malignant tumors (MTs) and either pleomorphic adenomas (PAs) or Warthin tumors (WTs). We further calculated diagnostic accuracy for distinguishing malignant from benign lesions when combining these parameters.

Results

PAs demonstrated significantly higher T1, T2, PD, and ADC values than WTs (all p < 0.001). Compared to MTs, PAs had significantly higher T1, T2, and ADC values (all p < 0.001), whereas WTs had significantly lower T1, T2, and PD values (p < 0.001, p = 0.008, and p = 0.003, respectively). T2 and ADC were most effective in differentiating between MTs and PAs (AUC = 0.928 and 0.939, respectively), and T1 and PD values for differentiating between MTs and WTs (AUC = 0.915 and 0.833, respectively). Combining T1 with T2 or ADC achieved accuracy of 86.4% in distinguishing between malignant and benign tumors. Similarly, combining PD with T2 or ADC reached accuracy of 86.4% for differentiating between malignant and benign tumors.

Conclusions

Utilizing a combination of synthetic MRI parameters may assist in differentiating malignant from benign salivary gland lesions.
Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke
Authors: Prisco Domenico , Canfora Maria , Mazzetti Matteo , Mattioli Irene , Bettiol Alessandra
Published: May 2024

Stroke is one of the most common causes of mortality and disability worldwide. Antithrombotic therapy represents the mainstay in primary and secondary prevention, both in cardioembolic and non-cardioembolic stroke. Particularly, direct oral anticoagulants play a crucial role in atrial fibrillation, the most common cause of cardioembolic stroke, whereas single or dual antiplatelet therapy is preferred in non-cardioembolic stroke. However, the limitations related to the residual risk of cardioembolic or cerebrovascular events, and the risk of major bleeding, still represent unmet medical needs. To overcome them, new drugs inhibiting Factor XI (FXI) and Factor XII have been proposed, with a selective inhibition of contact pathway of coagulation, delineating a new anticoagulant approach. This review provides a summary of the currently available evidence and future perspectives on FXI inhibitors, that can represent an additional therapeutic option in the primary and secondary prevention of cardioembolic and non-cardioembolic ischemic stroke, also in challenging therapeutic contexts.

Graphical Abstract
Towards a definition of “mathematical digital competency for teaching”
Authors: Geraniou Eirini , Jankvist Uffe Thomas , Elicer Raimundo , Tamborg Andreas Lindenskov , Misfeldt Morten
Published: May 2024

When students engage with a digital tool to tackle a mathematical task, the interplay between their digital competencies and mathematical abilities gives rise to what is termed mathematical digital competency (MDC). Recognising the significance of MDC as an integral component for contemporary students, the relevance of cultivating mathematical digital competency for teaching (MDCT) becomes apparent. We posit that for teachers to effectively guide students in the development of their MDC, possessing MDCT is imperative. In this paper, drawing upon the theoretical frameworks of instrumental orchestration, the documentational approach to didactics, and the Danish competencies framework’s six didactico-pedagogical competencies of mathematics teachers, we propose a theoretical conceptualization of teachers’ mathematical and digital competencies in the context of teaching mathematics with technology. Expanding upon the preliminary definition of students’ MDC, we incorporate pedagogic, theoretical elements tailored to teachers, encapsulating it as MDCT. To expound on the various facets of MDCT, we provide an illustrative example featuring a mathematics teacher proficient in the utilisation of digital technologies and programming.
Integrative Medicine Across the Pediatric Cancer Care Trajectory: A Narrative Review
Authors: Ben-Arye Eran , Samuels Noah , Seifert Georg , Gressel Orit , Peleg Raviv , Jong Miek
Published: May 2024

Purpose of the review

Children and adolescents with cancer, along with their parents and other informal caregivers, often report using complementary and alternative medicine (CAM) during active oncology and hemato-oncology treatment. Some adopt an “alternative” approach to conventional medical care, which often entails the use of these practices without the knowledge of the treating pediatrician. In contrast, many others search for consultation provided by a pediatric integrative oncology (IO) practitioner working with the conventional medical team. IO seeks to provide evidence-based complementary medicine therapies, many of which have been shown to augment conventional supportive and palliative care, while ensuring the patient’s safety. The present narrative review examines the current state of and future direction for the IO setting of care.

Recent findings

A large body of published clinical research supports the effectiveness of leading Pediatric IO modalities, while addressing potential safety-related concerns.

Despite the growing amount of clinical research supporting the beneficial effects and implementation of Pediatric IO models of care, there is still a need for further studies in order to establish clinical guidelines in the treatment of children and adolescents with cancer. Such IO-directed guidelines will need to address both the effectiveness and the safety of the CAM modalities being used in pediatric oncology and hemato-oncology settings, promoting a better understanding among pediatric healthcare professionals and helping them understand the indications for referral to the IO treatment service.
Exploring Quantitative Biological Major, Trace, and Ultratrace Elements Composition and Qualitative Primary-Secondary Metabolites in Lamiaceae Medicinal Plants from Turkey
Authors: Tekman Enes , Asgarlı Tugay , Yuca Hafize , Atila Alptuğ , Çeçen Ömer , Karakaya Songül
Published: May 2024

Medicinal plants comprise a spectrum of constituents, encompassing both organic and inorganic elements. Elemental composition of 27 species of medicinal plants of Lamiaceae (including 17 endemic) family grown in Turkey was carried out by ICP-MS. The following elements were determined in analysed samples: Na, Mg, Al, K, Ca, Sc, Cr, Mn, Fe, Co, Zn, As, Rb, Sr, Cs, Ba, La, Ce, Sm, U, Se. Quantitative analysis of specific primary and secondary metabolites was carried out. Na and K are major constituents in plants. The concentrations of Na range from 332,495.590 g/kg (in sample 10SA) to 279,690.674 g/kg (in sample 4SA), while those of K vary from 67,492.456 g/kg (in sample 15SA) to 3347.612 g/kg (in sample 1A). Some metals such as Al, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Cs, and Ba were also detected. Flavonoids, carbohydrates and tannins were present in all sample. Saponins were found in all samples except 1C and 2O. Coumarin were detected in samples 2N, 1 T, 1O, 1Z, 3SA, 1C, 4SA, 6SA, 8SA, 1 M, 11SA, 13SA, 2O, 14SA, 1H, and 16SI. Lipids were present in samples 6S, 9S, 1A, 10S, 1 M, 11SA, 12SA, 13SA, 14SA, and 16SI. Plants contain essential, rare earth, and trace elements at mg/kg concentrations, while major elements such as K and Na are present in high levels. Toxic element As (arsenic) was detected in all analyzed plants, but in most samples, its concentration was below the threshold set by World Health Organization.

Graphical Abstract
Civil Conflict’s Impact on the Pursuit of Inclusivity, Safety, Resilience and Sustainability in Anglophone Cities of Cameroon
Authors: Cho Derrick Teneng
Published: May 2024

Cities are increasingly becoming sites where violence and conflict thrive. In the African continent, civil conflict has been rife, with cities not only being targets but also hosts to civil unrest. Since 2016, Anglophone (English-speaking) cities in Cameroon have been host to a civil conflict that has had devastating impacts on the socio-economic well-being of the Anglophone regions, impeding efforts to achieve sustainable development goal 11 (SDG 11), related to inclusivity, safety, resilience and sustainability in Anglophone cities. Moreover, the conflict has deepened the divide between the Anglophone and Francophone populations, making peaceful coexistence between them increasingly difficult. Utilising a content analysis methodological approach, this paper examines the Anglophone Cameroon civil conflict through the lens of urban sustainability, looking to unravel how the conflict has affected efforts towards pursuing SDG 11 in Anglophone cities. The paper argues that civil conflict has robbed Anglophone cities of the required ingredient of socio-economic and political stability necessary for SDG 11 to thrive, and unless the civil conflict is curbed and a stable peace attained, the pursuit of inclusivity, safety, resilience and sustainability in Anglophone cities would be a futile venture. This paper recommends the establishment of a comprehensive approach to resolve the conflict in a way that considers the root causes of the conflict, as well as measures to foster urban sustainability in Anglophone cities. When this is done, it would be more feasible to attain inclusivity, safety, resilience, and sustainability in Anglophone cities.
Family functioning and mental health before and during the COVID-19 pandemic: a two-cohort comparison of emerging adults
Authors: del Carmen García-Mendoza María , de la Fuente Rocío , Sánchez-Queija Inmaculada , Parra Águeda
Published: May 2024

The aim of the present study was to analyze how family relationships changed during the COVID-19 pandemic and to determine whether the health crisis modified the association between family dimensions and emerging adult children’s mental health. A large sample of 1732 emerging adults was recruited at two different moments. In 2015, 755 emerging adults were recruited, 201 from campus A (sample 1) and 554 from campus B (sample 2). In 2020, a new sample was recruited and 977 emerging adults completed the questionnaire, 198 from campus A (sample 1 / “Pre-pandemic sample”, recruited before the lockdown) and 779 from campus B (sample 2 / “COVID-19 sample” / recruited after the lockdown. The results reveal that the COVID-19 sample of emerging adults perceived poorer parent-child relationships (lower parental involvement and warmth) and reported poorer mental health (lower flourishing and higher psychological distress) than their counterparts in Cohort 1. For their part, the Pre-pandemic sample reported higher levels of psychological distress than their counterparts in Cohort 1. In all samples (Cohort 1 and Cohort 2, both Pre-pandemic and COVID-19), parenting functions were positively associated with children’s flourishing and negatively associated with their psychological distress. However, these associations were stronger in Cohort 2 than in Cohort 1, both when assessed before and when assessed during the pandemic. The results of the study support the increasingly important role played by the family as a protective factor for mental health, even in stressful situations when family relationships tend to deteriorate. Study limitations include the use of a sample composed mainly of young emerging adult university students. Future studies should strive to include more emerging adults from the entire age range encompassed by emerging adulthood, as well as members of the non-university-going emerging adult population. Investing in public programs focused on family functions during emerging adulthood is an essential strategy for protecting and improving young adults’ mental health and promoting positive family relationships in stressful situations.
The moderating role of psychological power distance on the relationship between destructive leadership and emotional exhaustion
Authors: Korkmazyurek Yavuz , Ocak Metin
Published: May 2024

Destructive leadership, a prevalent negative behavior in modern organizations, continues to captivate the interest of scholars and professionals due to its detrimental aftermath. Drawing from social psychological (culture) and conservation of resources theory, we explore the moderating impact of psychological power distance on the link between destructive leadership and emotional exhaustion. The main contribution of this study is that it has created new information about the moderating role of some specific sub-dimensions of psychological power distance (e.g., hierarchy, prestige) in the relationship between destructive leadership and emotional exhaustion. Our findings also reveal a positive correlation between a destructive leadership style and emotional exhaustion. Furthermore, the prestige aspect of psychological power distance amplifies the influence of deficient leadership abilities and unethical conduct on emotional exhaustion. Notably, our study highlights that in the Turkish context, characterized by high power distance, and escalating hierarchies the impact of nepotism disparities on emotional exhaustion. In conclusion, these novel insights underscore a significant research avenue regarding cultural facets.
An examination of the relationship between height, height dissatisfaction, drive for thinness and muscularity, and eating disorder symptoms in north American women
Authors: Talbot Daniel , Mahlberg Justin
Published: May 2024

Recent research has evidenced the importance of height dissatisfaction in male body image, however the impact of height on body image in women remains relatively unexplored. Our study aimed to investigate the association between height, heightdissatisfaction, body dissatisfaction, and eating disorder symptoms in a sample of 139 women from the USA. Participants were recruited using Amazon's MTurk and reported their actual and ideal height, as well as completing measures of height dissatisfaction, and drive for thinness, drive for muscularity, and eating disorder symptoms. A paired sample t-test was utilised to examine differences in participants’ actual and ideal height. Additionally, linear hierarchical multiple regression was used to assess whether height, eating disorder symptoms, drive for thinness, and drive for muscularity uniquely predicted height dissatisfaction, and significant interactions were explored using a simple slope analysis complemented with a Johnson-Neyman analysis. Results showed that 48.92% of women reported identical actual and ideal height, 33.09% of women wanted to be taller, and 13.67% wanted to be shorter than their actual height. Additionally, shorter women tended to report greater height dissatisfaction, and higher levels of drive for thinness and drive for muscularity were associated with increased height dissatisfaction. However, eating disorder symptoms did not uniquely account for significant variance in height dissatisfaction once accounting for drive for thinness and muscularity. Our exploratory analysis also revealed that for taller than average women, height dissatisfaction was more strongly predicted by drive for muscularity, thus implicating the significance of height and muscle dissatisfaction for taller women. Overall, our study demonstrated that height and height dissatisfaction are important components to the theoretical construct of women’s body image, and therefore should be integrated into theoretical models of female body dissatisfaction and considered in assessment, formulation, and treatment of body image-related disorders. Further research with larger and more diverse samples, including clinical populations, is warranted to validate and extend our findings.
The Current State of Meniscus Replacements
Authors: van Minnen B. S. , van Tienen T. G.
Published: May 2024

Purpose of Review

The field of meniscus replacement is changing continuously, with new devices emerging and others disappearing from the market. With the current tendency to preserve the knee joint, meniscus implants may become more relevant than ever. The purpose of this review is to provide an overview of the current state of partial and total meniscus replacements that have been developed beyond the academic phase. The available clinical and pre-clinical data is evaluated, and omissions are identified.

Recent Findings

Recent systematic reviews have shown a lack of homogenous clinical data on the CMI and Actifit meniscal scaffolds, especially regarding long-term performance without concomitant surgical interventions. Clinical studies on the medial total meniscus prostheses NUsurface and Artimis are ongoing, with the NUsurface being several years ahead. New techniques for meniscus replacement are rapidly developing, including the Artimis lateral meniscus prosthesis and the MeniscoFix 3D-printed scaffold.

All evaluated clinical studies point towards improved clinical outcomes after implantation of partial and total meniscus replacements. Long-term data on survival and performance is of low quality for CMI and Actifit and is unavailable yet for NUsurface and Artimis. It is of major importance that future research focuses on optimizing fixation methods and identifying the optimal treatment strategy for each patient group. New techniques for total and partial replacement of the medial and lateral meniscus will be followed with interest.
Environmentally Friendly Coloration of Polyamide Fabrics with the Use of Natural Dyes: A Study Including Results of Industrial Scale Applications
Authors: Atav Rıza , Soysal Selma , Hajı Aminoddin
Published: May 2024

In recent years, it is seen that there have been many publications on natural dyes in literature. In the studies carried out, one or more plants were taken and the color and fastness obtained with them in the presence of different mordants were examined. Beyond that, functionalities such as odor, antibacterial activity, and UV protection that natural dyes impart to the fabric were examined. However, the important thing that the literature needs is to represent also the results related to the industrial scale production since industry shows high interest to be able to use natural dyes. In this study, seven plant dyes have been used for the coloration of polyamide fabric. The studies have been conducted both on an industrial scale and at the laboratory scale. Based on the statistical analyses, four dyes with the highest color strength and fastness properties including catechu, madder, mulberry leaf, and pomegranate peel were selected for more studies on industrial scale. The results confirmed the good color strength and satisfactory fastness properties against repeated washing, rubbing, water, and perspiration for all selected dyes. The samples dyed with those dyes exhibited excellent protection against UV radiation. The results obtained in this study showed the potential of the selected natural dyes in eco-friendly industrial dyeing of nylon fabric with acceptable fastness properties.
Are Subjective Benefits of Mindfulness-Based Stress Reduction Related to Changes in Cardiac and Cortical Responses to a Stress Task?
Authors: Nyklíček Ivan , van Boxtel Geert J. M. , van der Donk Loek J. , Kop Willem J. , Lodder Paul
Published: May 2024

Objectives

Mindfulness-Based Stress Reduction (MBSR) has been shown to decrease general feelings of distress. It is not known to what extent such beneficial effects are associated with attenuation of physiological responses to challenging psychological situations. The aim of the present study was to examine potential associations between general decreases in subjective distress and changes in acute cardiac and cortical responses during recall of a recent stressful episode between pre- and post-MBSR.

Method

Fifty-eight MBSR participants (77.6% female, mean age 43.8 years, SD = 13.1) took part in a laboratory examination before and after MBSR. Measurements of the electrocardiogram (ECG) and electroencephalogram (EEG) were performed during the whole protocol including the stress recall task.

Results

The MBSR group showed overall decreases in general negative affect and an increase in heart rate variability from pre- to post-intervention. Out of six physiological outcomes (heart rate, heart rate variability, theta, alpha, beta, and gamma power at Fz), only a decreased response of gamma power during the stress task was significant. The subjective and physiological changes were unrelated.

Conclusions

The present results suggest that the favourable effects of MBSR on general stress reduction may not be clearly reflected in cortical electrical wave activity or vagal cardiac response during recall of a recent stressful episode. The few changes found in cardiac and cortical activity may be due to either effects independent of general subjective feelings or independent of the intervention altogether.

Preregistration

The study is not preregistered.
Identification of NINJ1 as a novel prognostic predictor for retroperitoneal liposarcoma
Authors: Zhao Yu , Qin Da , Li Xiangji , Wang Tiange , Zhang Tong , Rao Xiaosong , Min Li , Wan Zhiyi , Luo Chenghua , Xiao Mengmeng
Published: May 2024

Background

Retroperitoneal liposarcoma (RPLS) is known for its propensity for local recurrence and short survival time. We aimed to identify a credible and specific prognostic biomarker for RPLS.

Methods

Cases from The Cancer Genome Atlas (TCGA) sarcoma dataset were included as the training group. Co-expression modules were constructed using weighted gene co-expression network analysis (WGCNA) to explore associations between modules and survival. Survival analysis of hub genes was performed using the Kaplan–Meier method. In addition, independent external validation was performed on a cohort of 135 Chinese RPLS patients from the REtroperitoneal SArcoma Registry (RESAR) study (NCT03838718).

Results

A total of 19 co-expression modules were constructed based on the expression levels of 26,497 RNAs in the TCGA cohort. Among these modules, the green module exhibited a positive correlation with overall survival (OS, p = 0.10) and disease-free survival (DFS, p = 0.06). Gene set enrichment analysis showed that the green module was associated with endocytosis and soft-tissue sarcomas. Survival analysis demonstrated that NINJ1, a hub gene within the green module, was positively associated with OS (p = 0.019) in the TCGA cohort. Moreover, in the validation cohort, patients with higher NINJ1 expression levels displayed a higher probability of survival for both OS (p = 0.023) and DFS (p = 0.012). Multivariable Cox analysis further confirmed the independent prognostic significance of NINJ1.

Conclusions

We here provide a foundation for the establishment of a consensus prognostic biomarker for RPLS, which should not only facilitate medical treatment but also guide the development of novel targeted drugs.
A ferroptosis-related signature predicts the clinical diagnosis and prognosis, and associates with the immune microenvironment of lung cancer
Authors: Zhou Hua , Zhou Xiaoting , Zhu Runying , Zhao Zhongquan , Yang Kang , Shen Zhenghai , Sun Hongwen
Published: May 2024

Targeting ferroptosis-related pathway is a potential strategy for treatment of lung cancer (LC). Consequently, exploration of ferroptosis-related markers is important for treating LC. We collected LC clinical data and mRNA expression profiles from TCGA and GEO database. Ferroptosis-related genes (FRGs) were obtained through FerrDB database. Expression analysis was performed to obtain differentially expressed FRGs. Diagnostic and prognostic models were constructed based on FRGs by LASSO regression, univariate, and multivariate Cox regression analysis, respectively. External verification cohorts GSE72094 and GSE157011 were used for validation. The interrelationship between prognostic risk scores based on FRGs and the tumor immune microenvironment was analyzed. Immunocytochemistry, Western blotting, and RT-qPCR detected the FRGs level. Eighteen FRGs were used for diagnostic models, 8 FRGs were used for prognostic models. The diagnostic model distinguished well between LC and normal samples in training and validation cohorts of TCGA. The prognostic models for TCGA, GSE72094, and GSE157011 cohorts significantly confirmed lower overall survival (OS) in high-risk group, which demonstrated excellent predictive properties of the survival model. Multivariate Cox regression analysis further confirmed risk score was an independent risk factor related with OS. Immunoassays revealed that in high-risk group, a significantly higher proportion of Macrophages_M0, Neutrophils, resting Natural killer cells and activated Mast cells and the level of B7H3, CD112, CD155, B7H5, and ICOSL were increased. In conclusion, diagnostic and prognostic models provided superior diagnostic and predictive power for LC and revealed a potential link between ferroptosis and TIME.
HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation
Authors: Li Jiamin , Wang Zixin , Li Jiameng , Zhao Haiping , Ma Qingfeng
Published: May 2024

Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration of rtPA is essential for restoring perfusion in acute ischemic stroke, though it concurrently elevates the risk of hemorrhagic transformation. High-mobility group box 1 (HMGB1) emerges as a pivotal player in neuroinflammation after brain ischemia and ischemia–reperfusion. Released passively by necrotic cells and actively secreted, including direct secretion of HMGB1 into the extracellular space and packaging of HMGB1 into intracellular vesicles by immune cells, glial cells, platelets, and endothelial cells, HMGB1 represents a prototypical damage-associated molecular pattern (DAMP). It is intricately involved in the pathogenesis of atherosclerosis, thromboembolism, and detrimental inflammation during the early phases of ischemic stroke. Moreover, HMGB1 significantly contributes to neurovascular remodeling and functional recovery in later stages. Significantly, HMGB1 mediates hemorrhagic transformation by facilitating neuroinflammation, directly compromising the integrity of the blood–brain barrier, and enhancing MMP9 secretion through its interaction with rtPA. As a systemic inflammatory factor, HMGB1 is also implicated in post-stroke depression and an elevated risk of stroke-associated pneumonia. The role of HMGB1 extends to influencing the pathogenesis of ischemia by polarizing various subtypes of immune and glial cells. This includes mediating excitotoxicity due to excitatory amino acids, autophagy, MMP9 release, NET formation, and autocrine trophic pathways. Given its multifaceted role, HMGB1 is recognized as a crucial therapeutic target and prognostic marker for ischemic stroke and hemorrhagic transformation. In this review, we summarize the structure and redox properties, secretion and pathways, regulation of immune cell activity, the role of pathophysiological mechanisms in stroke, and hemorrhage transformation for HMGB1, which will pave the way for developing new neuroprotective drugs, reduction of post-stroke neuroinflammation, and expansion of thrombolysis time window.
“Sex Out of Boredom”: Key Stakeholders’ Perspectives on Teen Pregnancy Prevention in Emerging Immigrant Latino Rural Communities
Authors: Barral Romina L. , Fortenberry J. Dennis , Avitia Astrid Guerrero , Ramirez Mariana , Masonbrink Abbey R. , Brindis Claire D.
Published: May 2024

Introduction

Teen pregnancy (TP) rates are 1.5 times higher among Latina youth than the United States national average and one-third times higher in rural counties. The Socio-Ecological framework recognizes the myriad of issues that impact TP, including four bidirectional levels of influence on teenagers’ behaviors: macro, community, institutional, and interpersonal levels. We aim to fill critical knowledge gaps regarding the influence of key community stakeholders living in rural, Latino-majority communities shaping Latino/a, immigrant adolescents’ TP-related environments.

Methods

A purposive sample of 48 key stakeholders was drawn from three rural counties (Finney, Ford, and Seward) in southwestern Kansas from 2016 to 2017; participants completed a brief demographic survey and a semi-structured qualitative interview. Qualitative data analysis followed grounded theory within a Socio-Ecological framework, and we used descriptive statistics to analyze survey data.

Results

Respondents (N = 48) included 5 public health department staff, 8 community health workers, 8 healthcare workers, 9 community members, and 18 high school/college administrators. The mean age was 43 years (SD = 15.5) and 50% self-identified as Latino/a. Recommendations included developing TP prevention education programs for parents, utilizing ongoing events and familiar venues, and keeping content consistent with local culture and norms.

Conclusions

Key stakeholders’ perceptions regarding TP are often unaccounted for but play a role in shaping youth’s decision-making environments.

Policy Implications

This information could inform the development of culturally specific TP prevention interventions, especially considering the controversial politics centered on immigration to the U.S. and its negative impact on the overall health of Immigrant Latinos living in the U.S.
Enhancing a machine learning model for predicting agricultural drought through feature selection techniques
Authors: Nikdad Pardis , Mohammadi Ghaleni Mehdi , Moghaddasi Mahnoosh , Pradhan Biswajeet
Published: May 2024

This study aims to determine the crucial variables for predicting agricultural drought in various climates of Iran by employing feature selection methods. To achieve this, two databases were used, one consisting of ground-based measurements and the other containing six reanalysis products for temperature (T), root zone soil moisture (SM), potential evapotranspiration (PET), and precipitation (P) variables during the 1987–2019 period. The accuracy of the global database data was assessed using statistical criteria in both single- and multi-product approaches for the aforementioned four variables. In addition, five different feature selection methods were employed to select the best single condition indices (SCIs) as input for the support vector regression (SVR) model. The superior multi-products based on time series (SMT) showed increased accuracy for P, T, PET, and SM variables, with an average 47%, 41%, 42%, and 52% reduction in mean absolute error compared to SSP. In hyperarid climate regions, PET condition index was found to have high relative importance with 40% and 36% contributions to SPEI-3 and SPEI-6, respectively. This suggests that PET plays a key role in agricultural drought in hyperarid regions because of very low precipitation. Additionally, the accuracy results of different feature selection methods show that ReliefF outperformed other feature selection methods in agricultural drought modeling. The characteristics of agricultural drought indicate the occurrence of drought in 2017 and 2018 in various climates in Iran, particularly arid and semi-arid climates, with five instances and an average duration of 12 months of drought in humid climates.
Skating into the Unknown: Scoping the Physical, Technical, and Tactical Demands of Competitive Skateboarding
Authors: Diewald Shelley N. , Neville Jono , Cronin John B. , Read David , Cross Matt R.
Published: May 2024

Background

The inclusion of skateboarding in the Olympics suggests that athletes and coaches are seeking ways to enhance their chances of succeeding on the world stage. Understanding what constitutes performance, and what physical, neuromuscular, and biomechanical capacities underlie it, is likely critical to success.

Objective

The aim was to overview the current literature and identify knowledge gaps related to competitive skateboarding performance and associated physical, technical, and tactical demands of Olympic skateboarding disciplines.

Methods

A systematic scoping review was performed considering the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (Extension for Scoping Reviews) guidelines. Data sources were MEDLINE (Ovid), Scopus, SPORTDiscus, and PubMed. We included all peer-reviewed literature after 1970 describing the physiological, neuromuscular, biomechanical, and/or tactical aspects of skateboarding.

Results

Nineteen original articles explored the physiological (n = 9), biomechanical (n = 8), and technical (n = 10) demands of skateboarding. No research explored the tactical demands of competition. Moreover, although competitive males (n = 2 studies) and females (n = 1 study) were recruited as participants, no research directly related skateboarding demands to performance success in competitive environments.

Conclusions

Ultimately, what constitutes and distinguishes competitive skateboarding is unexplored. There is some evidence indicating aspects of the sport require flexibility and elevated and fast force output of the lower limbs, which may be valuable when attempting to maximise ollie height. Nonetheless, a lack of ecological validity, such as using static ollie tests as opposed to rolling, restricted our ability to provide practical recommendations, and inconsistency of terminology complicated delineating discipline-specific outcomes. Future researchers should first look to objectively identify what skaters do in competition before assessing what qualities enable their performance.
Multi-agent dynamic formation interception control based on rigid graph
Authors: Wang Chuanyun , Sun Yunfei , Ma Xiaoping , Chen Qi , Gao Qian , Liu Xiaona
Published: May 2024

In this study, dynamic formation tracking and interception are performed by controlling multi-agent using a Euler-like Lagrangian model. The purpose is to use the distance-based rigid graph method to control multi-agent, and ultimately achieve dynamic formation tracking and target interception of multi-agent. Initially, distance-based graph stiffness and back-stepping techniques were considered to address the formation control challenge. This method helps achieve the initial expected formation and effectively complete the formation mission. Leaders continue to chase the moving target, while followers stick to the expected arrangement. The leader then precisely tracks the moving target and surrounds it within the formation. By using Lyapunov stability theory with adaptive control, it is ensured that the total distance meets finite and consistent error limits. Finally, the numerical simulation of the interception plan was carried out by 6 multi-agents and 1 target at different times to verify the effectiveness of the control method.
Inhibitory Effect and Mechanism upon Glucose-Insulin-Potassium Administration on Postpartum Mice with Uterine Cramping Pain
Authors: Yang Guiying , Long Zonghong , Chen Fang , Bao Xiaohang , Zuo Dukun , Tang Hong , Wu Zhuoxi , Li Hong
Published: May 2024

This study aimed to explore the effect of glucose-insulin-potassium (GIK) on postpartum uterine cramping pain(UCP) in mice and the possible underlying mechanisms. Thirty full-term pregnancy C57BL/6 mice, within 6 h after spontaneous labor, the mice were randomly assigned into the following three groups: the control group (group C), the oxytocin group (group O), and the GIK plus oxytocin group (group G). Group G and group O were administered GIK and normal saline, respectively, and 10 min later, oxytocin was injected intraperitoneally; group C received normal saline twice. The pain scores of the mice were assessed after establishment of the postpartum UCP model. The differential expressions of energy metabolism and oxidized lipid metabolites in the uterus were analyzed. The behavioral scores in group G were significantly lower than those in group O (P < 0.05).When compared to group O, group G showed a significant increase in ATP levels (P = 0.046), and group G exhibited elevated levels of amino acids, including L-glutamine, L-aspartic acid, and ornithine. Additionally, phosphate compounds (2-phosphoglyceric acid and 3-phosphoglyceric acid) showed elevated levels. When compared to group O, group G exhibited a decrease in 19R-hydroxy PGF2α, an increase in 9,10-EpOME and 12,13-EpOME, and a decrease in trans-EKODE-E-Ib. Additionally, group G showed an elevation in 16,17-EpDPE and 8-HDoHE. This study confirms the analgesic effect of GIK during postpartum oxytocin infusion. Metabolomics and glycolysis product analysis suggest that GIK’s alleviation of UCP is associated with its enhancement of glycolysis and the influence of phenylalanine synthesis, aspartate metabolism, and arginine synthesis pathways. Additionally, the effects of GIK appears to be linked to its influence on the linoleic acid metabolic pathway.
Cyclic AMP-regulatory element-binding protein: a novel UV-targeted transcription factor in skin cancer
Authors: Nayar Julianne C. , Abboud Myriam , Dixon Katie M.
Published: May 2024

Common therapeutics in relation to melanoma and non-melanoma cancers include the use of kinase inhibitors. The long-term benefits of kinases, however, are limited by development of drug resistance. An alternative approach for treatment would be to focus on transcription factors. Cyclic AMP-regulatory element-binding protein (CREB) is a transcription factor that is commonly overactivated or overexpressed in many different cancers including skin cancer. Ultraviolet radiation (UVR), one of the main causes of skin cancer, can activate CREB in both melanocytes and keratinocytes. In addition, CREB has been found to be activated in skin cancers. Considering the prominent role that CREB plays in skin cancers, the studies reviewed herein raise the possibility of CREB as a potential prognostic and diagnostic marker of skin cancer and a novel target for therapeutic intervention.

Graphical Abstract
Multiscale study of reactive transport and multiphase heat transfer processes in catalyst layers of proton exchange membrane fuel cells
Authors: Zhang Ruiyuan , Chen Li , Min Ting , Mu Yu-Tong , Hao Liang , Tao Wen-Quan
Published: May 2024

Improving the performance of proton exchange membrane fuel cells (PEMFCs) requires deep understanding of the reactive transport processes inside the catalyst layers (CLs). In this study, a particle-overlapping model is developed for accurately describing the hierarchical structures and oxygen reactive transport processes in CLs. The analytical solutions derived from this model indicate that carbon particle overlap increases ionomer thickness, reduces specific surface areas of ionomer and carbon, and further intensifies the local oxygen transport resistance (Rother). The relationship between Rother and roughness factor predicted by the model in the range of 800-1600 s m-1 agrees well with the experiments. Then, a multiscale model is developed by coupling the particle-overlapping model with cell-scale models, which is validated by comparing with the polarization curves and local current density distribution obtained in experiments. The relative error of local current density distribution is below 15% in the ohmic polarization region. Finally, the multiscale model is employed to explore effects of CL structural parameters including Pt loading, I/C, ionomer coverage and carbon particle radius on the cell performance as well as the phase-change-induced (PCI) flow and capillary-driven (CD) flow in CL. The result demonstrates that the CL structural parameters have significant effects on the cell performance as well as the PCI and CD flows. Optimizing the CL structure can increase the current density and further enhance the heat-pipe effect within the CL, leading to overall higher PCI and CD rates. The maximum increase of PCI and CD rates can exceed 145%. Besides, the enhanced heat-pipe effect causes the reverse flow regions of PCI and CD near the CL/PEM interface, which can occupy about 30% of the CL. The multiscale model significantly contributes to a deep understanding of reactive transport and multiphase heat transfer processes inside PEMFCs.
Exploring the significant problems confronting secondary schools history education: a baseline study
Authors: Fufa Fekede Sileshi , Tulu Abera Husen , Ensene Ketebo Abdiyo
Published: May 2024

The purpose of this baseline study is to determine the significant problems confronting history education in secondary school. The researchers employed qualitative research methods and case study design. The techniques that were employed to acquire credible data were document analysis, interviews, and classroom observation. Six experienced history education teachers and eight top-ten students from Sebeta town public secondary school were interviewed, and academic achievement statistics of 174 students in history education were analyzed. In addition eight lesson observations were carried out to validate the information gleaned from the interviews and document analysis. The study's findings show that the primary challenges influencing history education in Sebeta town public secondary schools were teaching strategy, a lack of awareness about implementing participatory teaching methods, a lack of comprehensiveness of the contents of history education teaching materials, and the issue of the bulkiness and scope of history education texts being covered on time. The findings also indicate the significance of training history education teachers to use participatory teaching tactics, as well as the need for curriculum experts to better coordinate the range of history education content and teaching strategies. The findings of this study will help teachers, practitioners, scholars, policymakers, and educational professionals find solutions to significant problems in secondary school history education, as well as develop effective techniques for teaching history education in secondary schools that involve twenty-first century skills and abilities.
The effect of leachates on the physical and engineering properties of subsoil varies across different rock types and depth layers
Authors: Ale Temitayo Olamide , Ogunribido Tolulope Henry , Ademila Omowumi , Akingboye Adedibu Sunny
Published: May 2024

Waste disposal on land is a major environmental issue that affects groundwater through soil. The aim of this study is to evaluate and compare the physical and engineering properties of subsoil at varying depths from different dumpsites and to determine the effects of leachates and parent rock types on these soil properties. Thirty-six subsoil samples were obtained from twelve trial pit profiles at depths of 0.5 m, 1.0 m and 1.5 m respectively. These soil samples were subjected to both geotechnical index and strength tests. Grain size analysis, linear shrinkage, CBR and compaction tests revealed that many of the soil samples from dumpsites and their environs met the criteria of a good landfill material. All the soil samples have low permeability that ranges from 2.07 × 10–6 to 1.49 × 10–4. Liquid limit, plasticity index and MDD values were higher in the control samples while the dumpsite soils became more permeable. The results of grain size analysis, linear shrinkage and CBR revealed that there was no significant difference in the properties of dumpsite and control soils. All the soil samples have TDS and EC values below 1000 ppm and 1000 µS/cm, except for trial pit 1, suggesting that the soil has a low risk of leaching contaminants into groundwater. For analysis of variance and Pearson’s correlation coefficient, the P values of some parameters such as pH, EC, TDS, CBR, OMC, MDD, SG, LS, PI and LL were significant at a 0.05 level of significance. The following pairwise parameters: pH-MDD, TDS-CBR, EC-CBR, OMC-MDD and TDS-EC recorded strong positive correlation values for the three dumpsites. The statistical analyses reveal that the soil's properties were only slightly influenced by parent rock types and can be used to limit contaminant flow into the groundwater in the short term.