bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning
Authors: Consortium The COVID Moonshot , Chodera John , Lee Alpha , London Nir , Delft Frank von
Published: November 2020

Herein we provide a living summary of the data generated during the COVID Moonshot project focused on the development of SARS-CoV-2 main protease (Mpro) inhibitors. Our approach uniquely combines crowdsourced medicinal chemistry insights with high throughput crystallography, exascale computational chemistry infrastructure for simulations, and machine learning in triaging designs and predicting synthetic routes. This manuscript describes our methodologies leading to both covalent and non-covalent inhibitors displaying protease IC50 values under 150 nM and viral inhibition under 5 uM in multiple different viral replication assays. Furthermore, we provide over 200 crystal structures of fragment-like and lead-like molecules in complex with the main protease. Over 1000 synthesized and ordered compounds are also reported with the corresponding activity in Mpro enzymatic assays using two different experimental setups. The data referenced in this document will be continually updated to reflect the current experimental progress of the COVID Moonshot project, and serves as a citable reference for ensuing publications. All of the generated data is open to other researchers who may find it of use.
Total Synthesis of Tiacumicin B: Study of the Challenging β-Selective Glycosylations
Authors: Tresse cedric , François-Heude Marc , Servajean Vincent , Ravinder Rubal , Lesieur Clemence , Geiben Lucie , Jeanne-Julien Louis , Steinmetz Vincent , Retailleau Pascal , Roulland Emmanuel , Beau Jean-Marie , Norsikian Stephanie
Published: November 2020

We report here a full account of the total synthesis of tiacumicin B (Tcn-B), a natural glycosylated macrolide with remarkable antibiotic properties. Our strategy is based on our experience with the synthesis of the tiacumicin B aglycone and on unique 1,2-cis-glycosylation steps. It features the conclusive use of sulfoxide anomeric leaving-groups in combination with a remote 3-O-picoloyl group on the donors allowing highly beta-selective rhamnosylation and noviosylation that rely on H-bond-mediated Aglycone Delivery (HAD). The rhamnosylated C1-C3 fragment was anchored to the C4-C19 aglycone fragment by a Suzuki-Miyaura cross-coupling. Ring-size selective Shiina macrolactonization provided a semi-glycosylated aglycone that was engaged directly in the noviosylation step with a virtually total beta-selectivity. Finally, a novel deprotection method was devised for the removal of a 2-naphthylmethylidene (Nap) ether on a phenol and efficient removal of all the protecting groups provided synthetic tiacumicin B.
Algerian Bee Pollen Classification by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) Combined with Chemometrics Analysis
Authors: Rebiai Abdelkrim
Published: November 2020

Bee pollen is prepared themselves by pollens collecting from plants and has nutritive and therapeutic properties that make it attractive for human health. It has a typical composition related to the botanical origin and geographical location. This study aims to distinguish and identify bee pollen belonging to different Algerian regions and different plants. A methodology for the identification of pollen was developed based on Attenuated Total Reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. This method is simple and fast where samples are not destroyed, also unsupervised statistical methods principal component analysis (PCA) and hierarchical clustering analysis (HCA) are performed. Seventy-two pollen samples were collected and the ATR-FTIR spectra were recorded without processing the samples. ATR-FTIR spectra analysis allowed a reliable determination of the components present in the different samples. Further, PCA and HCA were utilized to evaluate the differences and similarities between the collected samples. Indeed, the PCA score plot and HCA based on ATR-FTIR revealed the same discriminatory trend, where the samples were divided into three main classes based on their total bee pollen. As a result, the PCA along with the HCA was a good and consistent model for identifying and distinguishing pollen grains.
Measuring Attitude Towards Chemistry, Biology, and Math at a Hispanic-Serving Institution
Authors: Chang Jordan , Menke Erik
Published: November 2020

The Attitude toward the Subject of Chemistry Inventory (ASCI V1), as well as two modified versions of the ASCI V1, were administered twice (pre- and post-semester) to three samples of students. Confirmatory factor analysis (CFA) was performed to compare the survey structure with prior work by others, and showed similar structure for the three versions. The survey results were then evaluated to compare student attitude with respect to chemistry, biology, and math as well as changes in attitudes. This work was approved by UC Merced's IRB.
Novel Inhibitors of the Main Protease of SARS-CoV-2 Identified via a Molecular Dynamics Simulation-Guided in Vitro Assay
Authors: Loschwitz Jennifer , Jäckering Anna , Keutmann Monika , Olagunju Maryam , Eberle Raphael J. , Coronado Monika A. , Olubiyi Olujide O. , Strodel Birgit
Published: November 2020

For the COVID-19 pandemic caused by SARS-CoV-2, there are currently no effective drugs or vaccines to treat this coronavirus infection. In this study, we focus on the main protease enzyme of SARS-CoV-2, 3CL pro , which is critical for viral replication. We employ explicit solvent molecular dynamics simulations of about 150 compounds docked into 3CL pro ’s binding site and that had emerged as good main protease ligands from our previous in silico screening of over 1.2 million compounds. By incoporating protein dynamics and applying a range of structural descriptors, such as the ability to form specific contacts with the catalytic dyad residues of 3CL pro and the structural fluctuations of the ligands in the binding site, we are able to further refine our compound selection. Fourteen compounds including estradiol shown to be the most promising based on our calculations were procured and screened against recombinant 3CL pro in a fluorescence assay. Eight of these compounds have significant activity in inhibiting the SARS-CoV-2 main protease. Among these are corilagin, a gallotannin, and lurasidone, an antipsychotic drug, which emerged as the most promising natural product and drug, respectively, and might thus be candidates for drug repurposing for the treatment of COVID-19. In addition, we also tested the inhibitory activity of testosterone, and our results reveal testosterone as possessing moderate inhibitory potency against the 3CL pro enzyme, which may thus provide an explanation why older men are more severely affected by COVID-19.
Investigation of Island/ Single Core and Archipelago/ Multicore Enriched Asphaltenes and Their Solubility Fractions by Thermal Analysis Coupled to High Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Authors: Neumann Anika , Chacón-Patiño Martha L. , Rodgers Ryan P. , Rüger Christopher , Zimmermann Ralf
Published: November 2020

Despite extensive research, the molecular-level chemical characterization of asphaltenes, a highly aromatic solubility fraction of petroleum, remains an analytical challenge. This fraction is related to diverse problems in crude oil exploration, transportation, and refining. Two asphaltene architecture motifs are commonly discussed in literature, “island” (single core) and “archipelago” (multicore) type structures. The thermal desorption and pyrolysis behavior of island- and archipelago-enriched as-phaltenes and their extrography fractions was investigated. For this purpose, the evolved chemical pattern was investigated by thermal analysis coupled to ultrahigh resolution mass spectrometry (FT-ICR MS). Soft atmospheric pressure chemical ionization preserved the molecular information of the thermal emission profile. Time/temperature-resolved analysis allowed the chemical characterization of occluded material as well as of asphaltene building blocks during pyrolysis.Regarding the thermogravimetric information, the island-type enriched sample (Wyoming asphal-tenes) revealed a significantly higher coke residue after the pyrolysis process compared to the archi-pelago-type enriched sample (Athabasca asphaltenes). In contrast to whole asphaltenes, extrograph-ic fractions revealed occluded material evolved during the desorption phase. For the acetone frac-tion, this effect was most abundant and suggests cooperative aggregation.Pyrolysis revealed a bimodal behavior for most of the compound classes suggesting the presence of both architecture motifs in each asphaltene. DBE versus #C diagrams of the pyrolysis molecular pro-file revealed specific compositional trends: compounds with high DBE values and short alkylation likely to be originated from island-type asphaltenes, whereas species with low DBE values and high carbon numbers likely derive from archipelago-type asphaltenes.In the asphaltene structural debate, thermal analysis ultrahigh resolution mass spectrometry serves as additional technique and supplements results obtainable by other techniques, such as direct infu-sion approaches. Consistent results on the structural motifs are indicated by the molecular finger-print visualized by DBE versus #C diagrams and serve as measure for the dominance of a structural motif.
A Broadly Accessible Liquid Chromatography Method for Quantification of Six Nitrosamine Compounds and N,N-Dimethylformamide in Metformin Drug Products Using High Resolution Mass Spectrometry
Authors: Wu Qian , Kvitko Evgenia , Zenzola Nicola , Kucera Kaury , Light David
Published: November 2020

N-nitrosodimethylamine (NDMA) and the industrial solvent, N,N-dimethylformamide (DMF), are both probable human carcinogens that have been detected in pharmaceutical drug products like metformin, which is used to treat type II diabetes. Some lots of metformin drug products have exceeded the United States Food and Drug Administration (FDA) daily allowable intake limit for NDMA, while the presence of DMF has been detected at several orders of magnitude higher than NDMA. A recent study found that a low abundance isotope of DMF interferes with NDMA quantification by using a unique subset of LC-MS instruments capable of high mass resolution. In this study, an LC-HRMS method is developed that chromatographically separates NDMA from DMF in metformin drug products to eliminate interference. The method can detect nitrosamines and DMF under the current regulatory guidance for industry and provides a solution for simultaneously quantifying nitrosamines and DMF for a broad range of LC-MS instruments.
GULLY PLUGGING SPILLWAY IS AN EFFECTIVE GULLY REHABILITATION MEASURE: A CASE STUDY OF DISTRICT GUJRAT-PAKISTAN
Authors: Ayub Aqsa
Published: November 2020

Soil erosion is the universal land degradation event which invites an enormous challenge for its rehabilitation. Among all forms, gully erosion is the most worst and visible form of water erosion which cannot be controlled without any permanent gully stabilization structure. Therefore, the study was conducted to evaluate the impact of gully plugging spillway to rehabilitate the eroded land. For this purpose, a highly eroded site was selected within the study area, surveyed to estimate the structural design and brick masonry work was executed accordingly. The consequences of study clearly illustrated that straight drop spillway is an effective hydraulic structure which considerably fulfilled its objectives by plugging the gully to stop further erosion as well as stabilizing the eroded land.
GROUNDWATER STORAGE CHANGE ESTIMATION USING GRACE SATELLITE DATA IN INDUS BASIN
Authors: Salam Muhammad , Masud Cheema Muhammad Jehanzeb , Zhang Wanchang , Hussain Saddam , Khan Azeem , Bilal Muhammad , Arshad Arfan , Ali Sikandar , Zaman Muhammad Awais
Published: November 2020

Over exploitation of Ground Water (GW) has resulted in lowering of water table in the Indus Basin. While waterlogging, salinity and seawater intrusion has resulted in rising of water table in Indus Basin. The sparse piezometer network cannot provide sufficient data to map groundwater changes spatially. To estimate groundwater change in this region, data from Gravity Recovery and Climate Experiment (GRACE) satellite was used. GRACE measures (Total Water Storage) TWS and used to estimate groundwater storage change. Net change in storage of groundwater was estimated from the change in TWS by including the additional components such as Soil Moisture (SM), Surface water storage (Qs) and snowpack equivalent water (SWE). For the estimation of these components Global Land Data Assimilation system (GLDAS) Land Surface Models (LSMs) was used. Both GRACE and GLDAS produce results for the Indus Basin for the period of April 2010 to January 2017. The monitoring well water-level records from the Scarp Monitoring Organization (SMO) and the Punjab Irrigation and Drainage Authority (PIDA) from April 2009 to December 2016 were used. The groundwater results from different combinations of GRACE products GFZ (GeoforschungsZentrum Potsdam) CSR (Center for Space Research at University of Texas, Austin) JPL (Jet Propulsion Laboratory) and GLDAS LSMs (CLM, NOAH and VIC) are calibrated (April 2009-2014) and validated (April 2015-April 2016) with in-situ measurements. For yearly scale, their correlation coefficient reaches 0.71 with Nash-Sutcliffe Efficiency (NSE) 0.82. It was estimated that net loss in groundwater storage is at mean rate of 85.01 mm per year and 118,668.16 Km3 in the 7 year of study period (April 2010-Jan 2017). GRACE TWS data were also able to pick up the signals from the large-scale flooding events observed in 2010 and 2014. These flooding events played a significant role in the replenishment of the groundwater system in the Indus Basin. Our study indicates that the GRACE based estimation of groundwater storage changes is skillful enough to provide monthly updates on the trend of the groundwater storage changes for resource managers and policy makers of Indus Basin.
WATER RESOURCES HELPS İN THE EXPANSİON OF MOSQUİTOES COLONİES
Authors: Haroona Atif , Yaseen Tayyaba , Husnain Aqarab , Mehfooz Mehran , Umair Muhammad Umer , Jarar Muhammad Husnain , Naveed Usama , Khalid Faraz
Published: November 2020

In Pakistan, water storage bodies are often the most plentiful and active habitats of immature stages of mosquitoes. Mosquitoes are blood feeding type of vectors that bite a particular host and suck blood. As a result, these vectors transmit disease causing agents to the host system. The most common mosquitoes borne viral diseases in Pakistan are Chicken gunya, Dengue fever, west nile and Zika fever. These diseases are common in low and poor living standard areas. Death rate increases due to more attack of these fatal diseases. Mosquitoes breeding sites are water bodies, discarded tyres, water tanks, bottles, cups and ant traps. Various environmental agents i.e. temperature fluctuations and water resources, now increase the rate of mosquitos in most areas of Pakistan. There is a lack of basic medical education and knowledge about its pervention techniques in mosquito affected areas in Pakistan. The purpose of this review is to highlight the current status of emerging mosquito borne viral diseases in Pakistan, i.e. Chicken gunya, Dengue fever, est nile and Zika fever. There is more need of prevention strategies and understanding about factors involved in spreading of mosquito borne diseases.
PREVENTING THE TRANSITION OF CORONA THROUGH SCIENCE & TECHNOLOGY:GLOBALLY INTEGRATED SOCIETY TOWARDS POSITIVE CHANGE
Authors: Khan Adil Hakeem
Published: November 2020

The entire basis of science is technology, technology that facilitates us, it also cautions us how destructive it can be to use it wrongly. Such as Bhopal Gas Tragedy containing leakage of Methyl isocyanate or radiation from Japan’s atomic reactor due to Tsunami, it is an event that the slightest negligence of science or technology can lead to a major tragedy.Covid-19 is one such phenomenon, and it took a while to understand and it convert into form of a serious illness. The Pandemic Disease of the century, which is spreading its infection in the whole world, and is likely to be Seriously thought.
APPLICATION OF THE WESTERN ART FORM BASED ON ARTIFICIAL INTELLIGENCE
Authors: Filomeno Aguilar
Published: November 2020

The western artistic school understands the world through its form of expression, images creation from the consciousness which induces illusion, deal with concretion through decomposition, synthesis, overlap, art cross thinking.it reflects subconscious progress; The art school evolution from classical to modern, based on the objectives, from concretion ,impression to abstract art expression, artificial intelligence deepen the objective, scientific, rational and artistic exploration, less considering the unity of formation and content of the art in exploring the breakthrough, but the transcendence mechanism itself will continuing to research in the art field because of art nature, It will prompts the rationalization of western art in convergence and development constantly.
BENJAMIN FRANKLIN’S RELIGIOUS VIEWS MANIFESTED IN HIS AUTOBIOGRAPHY
Authors: Zhang Duan,
Published: November 2020

The Autobiography of Benjamin Franklin (hereafter referred to as Autobiography) by Benjamin Franklin is really recognized as an American spiritual book that highlights the struggle course of the American dream and shows meaningful moral truths. Within the work, Franklin’s unique experiences towards RELIGION and his deep reflections on it are surly “on display”. By a close reading of his Autobiography, this paper delves into and analyzes those religious statements contained in it, trying to help readers sort out Franklin’s complex religious complex. By paying special attention to certain narrative strategies used by Franklin, the present paper believes that Franklin’s religious, moral and ethical thoughts are full of contradictions and conflicts. However, Franklin’s organic absorption of puritanism, dialectical use of deism, and rational speculations of all religions enable him to form kind and tolerant religious ideas, and rational moral values, thus realizing the self-consummation of moral under religious philosophy.
UNIFICATION OF FORMER FATA WITH KPK AND ITS IMPACT ON DOMESTIC SANCTUARY
Authors: Nisar Muhammad , bibi Nafeesa , Malik Saba , khan Naushad , Majid Muhammad sakandar
Published: November 2020

FORMER FATA (Federally Administered Tribal Area), is the most praiseworthy part of Pakistan, always deemed to be the rudimentary part of Pakistani province known as KPK (Khyber Pakhtunkhwa). After countless efforts and protracted delay, it came into being on 31st, May 2018. However, after this historically important incident, many changes were observed in the overall economy as well as the sanctuary situation of the country. Very little research is available to highlight the positive as well as negative impacts on domestic sanctuary. Therefore, keeping in view the above-explained scenario present study is devised to highlight all these concerns as well as future perspectives to put Pakistan on the success staircase. In this study, various aspects of FORMER FATA are highlighted including the unification of cultural attributes of FORMER FATA and KPK, conversion of the Jirga method into legal management, transfiguration of educational set up from Madrassa to schools, colleges, and universities. The Domino effect of this study enlightens the unsatisfactory attitude of government authorities for bringing up the living standards of inhabitants of FORMER FATA along with dawdling development projects. Therefore, it is the utmost need of the hour for government authorities to understand the subject matter and reconsider the attributes of FORMER FATA by considering it vital part of KPK as well as of Pakistan.
AN ANALYSIS OF ABSALOM, ABSALOM! FROM THE PERSPECTIVE OF NEW HISTORICISM
Authors: Zhang Duan,
Published: November 2020

New Historicism subverts the traditional binary opposition between literature and history, highlights the operation of “power” and “discourse” within texts, and explores two-way concerns for history and texts. Under the perspective of new historicism, this paper aims to interpret how HISTORICITY OF TEXTS and TEXTUALITY OF HISTORY are embodied in Absalom, Absalom! by William Faulkner. The paper concludes that, Faulkner’s resorting to literary creation, on one hand, reflects the history and on the other hand, highlights the reality, which realizes the interaction between literature and history.
CLOUD BASED E-HEALTH CARE DATA SECURITY AND PRIVACY BY USING ADVANCED ENCRYPTION STANDARD AND WATERMARKING TECHNIQUE
Authors: Jaffar Daniya , Sajid Ahthasham , Jahangeer Asma , Wagan Raja Asif
Published: November 2020

In 21st century technological word now has bring a tremendous change to health care system is widely used by doctor patients and researchers. Patients use wearable device such as smart eyewear, foot wear, smart watches, which is use by both patient to wear and by doctor to monitor patient condition remotely on cloud. This provides time savage fastest treatment facility but as this data is huge in amount it’s very important to take care of security and privacy of the big data on cloud. Because the big data is not between patient and doctor it’s on cloud were several third parties like service providers and other unauthorized user are also present and they can easily fetch patient’s personal information for their own benefit. In this paper a novel approach based on advance encryption method and watermarking technique is presented to provide protection and security to e health data on cloud.
MARKETING OF MANDARIN ORANGE IN JAJARKOT DISTRICT: A VALUE CHAIN ANALYSIS
Authors: Sharma Sushmita , Upadhayaya Sachin
Published: November 2020

The study was conducted to analyze the value chain of mandarin orange in Jajarkot district with the objective of drawing value chain map, defining linkage and value governance and finding major constraints. Total 82 respondents were interviewed by a semi-structured questionnaire including 60 farmers, 5 retailers, 5 collectors, 10 consumers, and 2 processors. EXCEL 2019 and SPSS 20 were used to enter and analyze data. Grading and sorting were major value-adding activities while processing was done at the retailer level in end markets. Grading fetched 4.188% and 3.94% more profit in contractor and consumer level respectively. The Most dominating channel was farmer-local consumer (46%) where farmers sold produce to Jajarkot fair. The Average price at farmgate, retailer, collector and contractor were 39.08/kg, 61.2/kg, 46.75/kg, and 49.75/kg respectively. Productivity of mandarin was found 8.54 mt/ha and B/C ratio was found 2.56. Margin in farmer-collector-retailer-consumer channel was 29.25 and in farmer-retailer-consumer channel was 23.08. Producer share was found highest in channel 5 (60.13%) and market efficiency was found higher in channel 3 (4.88%). Similarly, price spread in channels 3,4 and 5 were 34.33%, 64.19%, and 66.75% respectively. Vertical Integration included farmer and nurseries in backward linkage and farmer and farmer collector in the forward linkage. High transport cost was the reason for the high price of mandarin. Overall, the trade of mandarin in Jajarkot was found buyer-driven. Major problems related to marketing were poor storage (0.877) and processing facilities (0.833). The study revealed that mandarin production is profitable and potential in Jajarkot.
IMPACT OF CUSTOMER SATISFACTION AND ATTITUDE TOWARDS INSURANCE COMPANY
Authors: Sarmad Muhammad , Younas Khadija , Raza Ali , Razzaq Allena , Younas Umair
Published: November 2020

The purpose of this study was to inspect the effect of customer satisfaction and customer attitude towards the investment in Insurance Companies. After the data was collected, SPSS 2.0 version were used to measure the data. Correctness of data entry was checked. Descriptive and percentage techniques are used for data analysis. Chi square and cross tabulation analysis are used to assess both relationships and effects as per the hypotheses of the study. The data which was collected through survey. About 120 Questionnaire were distributed in Burewala area, from which 103 questionnaire were received back. The limitations connected with analysis area unit acknowledged. There must to be more study on this subject to know the connection between these factors and their impact on one another. This analysis was on little scale, the sample size was also little. So, the study should conducted on large scale area along with larger sample size. This study is very helpful to see the effect of customer satisfaction toward insurance sector. Policies makers should developed the strategies for also those person whose income level is low. The originality in this research was the specific area. This research applied in Burewala area. Because in this area the research with these variable are not applied before.
COMPARATIVE STUDY ON CHINESE LIVE BROADCASTING INFLUENCE UNDER EPIDEMIC
Authors: Lv Qin
Published: November 2020

Under the impact of the new coronavirus epidemic, 2020 will become the most popular year for live streaming influence. This year, various industries, platforms and brands began to sell their products in the form of live broadcast influence. In addition to the super internet celebrity, live broadcast influencers also include entrepreneurs, stars and taobao grassroot bosses. Different identities of influencers have the same purpose, that is to marketing more products. This article will conduct a comparative analysis on the current status of the four types of influencers, and finally make a future outlook and put forward the challenges of live broadcasting influence to the traditional supply chain.
EFFECTIVENESS OF MAGNETIC STIMULATION FOR SCIATIC NERVE NEUROPATHY TREATMENT OF CHILDREN
Authors:   Tashkent Institute for Postgraduate Medical Education of the Republic of Uzbekistan, Shamansurov Sh. , Mirsaidova N.
Published: November 2020

24 children observed and treated, aged 3 to 15 years, with sciatic neuropathy. The first group of children (8 patients) received traditional medication and physiotherapy treatment. In the second group (14 patients), children and medication and physiotherapy received the damaged nerve's magnetic stimulation
CONDITION OF CENTRAL HEMODYNAMICS AND HEMOSTASIS IN PATIENTS WITH DIABETES DURING ANGIOPLASTIC VESSELS OF LOWER EXTREMITY
Authors:   Tashkent Medical Academy of the Republic of Uzbekistan, Alavi А. , Jabbarov A. , Maqsudova M. , Isomiddinov A.
Published: November 2020

The increase in the number of diabetes patients and its complications remains one of the medical and social problems, despite modern medicine’s achievements. According to WHO estimates, in 2010, 239.4 million people were registered in the world with diabetes. By 2025, this figure is expected to reach 350 million. In diabetes, the risk of cardiovascular diseases increases, and many studies have shown that peripheral artery disease is one of the main causes of death in diabetes.
ROLE OF ULTRASOUND IN THE DETECTION OF RECURRENT OVARIAN CANCER
Authors:   Tashkent Medical Academy of the Republic of Uzbekistan, Alisherova M. , Ismailova M.
Published: November 2020

Currently, there are no standard approaches to monitoring patients with ovarian cancer (OC). While the role of ultrasound (US) has been identified in the primary diagnosis of OS, it is still controversial during the subsequent surgical treatment of OC. In world statistics, ovarian cancer is consistently among the four main localizations of malignant tumors of the female reproductive system, along with tumors of the breast, body and cervix.
ASSESSMENT OF KIDNEY FUNCTIONAL RESERVE ON THE BACKGROUND OF ANTI-AGGREGATE THERAPY IN CHRONIC KIDNEY DISEASE II-III STAGE
Authors:   Tashkent Medical Academy of the Republic of Uzbekistan, Barnoev Khabib
Published: November 2020

The article presents the results of a study to assess the functional reserve of the kidneys against the background of a comparative study of antiaggregant therapy dipyridamole and allthrombosepin in 50 patients with a relatively early stage of chronic kidney disease. Studies have shown that long-term administration of allthrombosepin to patients has resulted in better maintenance of kidney functional reserves. Therefore, our research has once again confirmed that diphtheridamol, which is widely used as an antiaggregant drug in chronic kidney disease, does not lag behind the domestic raw material allthrombosepin
PLANTING BASICS FOR VEGETABLE GROWING
Authors:   Samarkand institute of veterinary medicine of the Republic of Uzbekistan, Shodiev Xodjimurod , Mirzaxodjayev Sherzodxuja
Published: November 2020

Currently, the technological process of planting (transplanting) seedlings of such crops as tomatoes, eggplants, cabbage, bell peppers, bitter gourd, grown when growing high-yielding, vitamin-rich vegetable crops, is almost 100%. With power, work gets done at low productivity and high costs
PHYTOPLANKTON DEVELOPMENT DEPENDING ON THE SEASON IN THE PONDS OF THE CLEANING FACILITIES
Authors:   Bukhara branch of Tashkent Institute of Irrigation and Agricultural Mechanization Engineers of the Republic of Uzbekistan, Mustafaeva Mamlakat , Khakimova Zarina
Published: November 2020

The article presents an ecofloristic analysis of the natural algal population of reservoirs used as biological storage ponds, sedimentation tanks. Studies have shown that phytoplankton communities in reservoirs are not constant, and the composition and quantitative indicators of algaein them vary depending on meteorological conditions. In this Chapter, we consider seasonal changes in the abundance and biomass of phytoplankton, as well as their ratios in different ponds
ESG risks Management in Commercial Organizations
Authors: Smirnov V. D.
Published: November 2020

The study subject of this paper is the identification of changes in public perception of environmental problems, social and corporate governance issues, and the risks arising from its. The goal is going to be finding ways to manage these risks. The research’s methodology envisages a consistent analysis of impact of the amended approaches of society on the basic aspects of companies’ activities, starting from the investment stage, with definition of qualitative and quantitative parameters of the likely risks and benefits associated with the introduction of sustainable development principles by commercial organizations. The result of the study is identification a degree of impact of acceptance of importance or refusal of management of the specified risks on companies’ financial result and its value for shareholders and investors. It is substantiated that nowadays the motivation of investors is determined not only by financial performance of the company, but also by its efforts to comply with the changed ideas of state and society about interaction of the economy and the environment, relations between people. Recommendations are formulated for companies to manage these risks, which are important for all sectors of the economy.
Legal competence development of the teacher in sphere of preschool education
Authors: Bicheva I. B. , Kaznacheeva S. N.
Published: November 2020

Introduction.The authors point to the relevance of the problem of the legal competence development of a teacher in the sphere of preschool legal education. The requirements determined by the Federal State Educational Standards of Preschool Education in the field of legal education and social training of the child indicate the need for its development.

Materials and Methods.The authors used methods of analysis, systematization and generalization of scientific literature according to the research problem, experimental research of the development level of a preschool teacher's legal competence. The purpose of the article is to develop a model for the development of legal competence of a preschool teacher.

Results.The authors understand legal competence of a preschool teacher as a complex of components (value-motivational, content-legal, functional-activity, reflexive-evaluative), the formation of which ensures a more effective organization of work on legal education of pupils. The authors distinguish three levels of its formation (high, medium, low) and characterize them. There are results of studying the level of formation of the legal competence of a preschool teacher.

The authors have developed a model for the development of legal competence of a preschool teacher, focused on the modern values of the preschool education system, the continuity of the teacher's personal and professional development, the formation of his legal attitudes, methods of professional and legal activity. There are the pedagogical conditions for its realization. There are examples of recommended forms and methods of developing the legal competence of a preschool teacher in a preschool educational organization.

Discussion and Conclusions.The authors emphasize the need to develop the legal competence of a preschool teacher as a component of their professional competence. Its high level of formation is the basis for the formation of the legal competence of pupils. As a prospect for further research, the authors designate the approbation of the model for the development of legal competence of a preschool teacher and the verification of the pedagogical conditions for its implementation in the conditions of a preschool educational organization.
Professional portrait of Teacher of Russian as a Foreign Language: competence-based approach
Authors: Latukhina A. L. , Marinina Ju. A.
Published: November 2020

Introduction. One of the urgent problems of modern education is building a professional competence model of a specialist in order to increase the effectiveness of training and the formation of professional competencies necessary for a successful entry into the profession. From this point of view, the description of a professional portrait of Teacher of Russian as a Foreign Language will contribute to the most effective design of educational programs in this area of training.

Materials and Methods. In the course of the work, theoretical and empirical research methods were used: analysis, synthesis, generalization, comparison, juxtaposition, scientific theorization.

Results.In the preparation of Teacher of Russian as a Foreign Language, two models were initially laid down: when the teacher is a native speaker and when he himself learns Russian as a foreign language and subsequently broadcasts the acquired knowledge to foreign students. The main difference between these portraits of teachers is the presence of a foreign language communicative competence in the training of foreign language teachers, as well as the formation and improvement of a foreign language reading competence. At the same time, the common, uniting both models, are the psychological, pedagogical, methodological, intercultural and acmeological competences, which constitute the portrait of Teacher of Russian as a Foreign Language. The designated competencies made it possible to formulate professional competencies in educational programs in the direction of training «Pedagogical education» at the bachelor's and master's degrees at the Nizhny Novgorod State Pedagogical University named after Kozma Minin (44.03.01 «Russian as a foreign language» and 44.04.01 «Teaching Russian as a foreign language») and the corresponding sets of regulatory documents. 

Discussion and Conclusions. Teacher of Russian as a foreign language being a translator of Russian culture, it should be a competent, erudite, tolerant, ready for intercultural communication, striving for constant professional improvement, having both general pedagogical and specialized competencies.
THE EFFECTS OF PYRETHRUM EXTRACT ON Galleria mellonella HEMOLYMPH PHENOLOXIDASE ENZYME
Authors: KAYA Serhat
Published: November 2020

Pyrethrum is a natural neurotoxic insecticide which is obtained from the flowers of Chrysanthemum cinerariaefolium plant. Pyrethrum extract causes DNA damage, genotoxic effect, induction of autophagy and apoptosis, mitochondrial dysfunction, oxidative stress, inhibition of biochemical processes. The greater wax moth Galleria mellonella L. (Lepidoptera: Pyralidae) is gaining increasing attention in immunity studies as an invertebrate model organism. Melanization, which is the most important response of invertebrate humoral immunity, occurs when inactive prophenoloxidase turns into phenoloxidase enzyme. Changes in phenoloxidase enzyme activity are an important marker for humoral immunity. In our study, the phenoloxidase enzyme activity of hemolymph collected from G. mellonella larvae treated with different doses of pyrethrum extract was determined by reading against a certain absorbance in an ELISA microplate reader. The findings obtained from this study showed that 0.6 mg/ml pyrethrum extract increased phenoloxidase enzyme activity. Doses above and below this dose did not cause a significant change in phenoloxidase activity compared to control groups. In the evaluation made in terms of the change of enzyme activity over time, while the enzyme activity increased rapidly in the first 15 minutes, the enzyme activity rate decreased after the 20th minute. The effect of pyrethrum extract on phenoloxidase enzyme activity in G. mellonella larval hemolymph at a certain dose is consistent with the literature. The reason for this effect of the extract is closely related to its genotoxic and cytotoxic effects.
Non-financial value creation due to non-financial data reporting quality
Authors:   Silesian University of Technology, Faculty of Organization and Management, Department of Economics and Computer Science, ORZEŁ Bartosz
Published: November 2020

Purpose:The main purpose of this article is to show non-financial value creation due to CSR 6reporting processes, a study on reports standards, types of reports submit by Polish enterprises 7and the statistics of the usage of these standards.8Design/methodology/approach:In this paper,GRI guideline requirements werepresented as 9a path to good-quality report creation. Additionally, anexample of quality assurance in CSR 10reporting in accordance withGRI guideline requirements was presented. The paper is based on 11the case study method. 12Findings:The result of the literature analysis is to show an approach to reportingnon-financial 13data in a comprehensive manner and in accordance with GRI guidelines.The other aspect is to 14show theinfluence of CSR reporting quality onnon-financial value.15Social implications:Reporting ofcorporate social responsibility by business organisations and 16entities is an example of improving the quality of human life, in particular in economic, social 17and environmental issues. The constant improvement of non-financial data reporting has 18significant impact on safety and sustainability in business and social development.19Originality/value: The paper shows specific view on non-financial value in connectionwith20stakeholders and organisations’ interest groups. 21Keywords:Non-financial value, CSR report quality, CSR reports, CSR reporting statistics, 22GRI guidelines.23Category of the paper: Case study, literature review.
THE FINANCIAL CRISIS: WHAT IMPACT ON THE ECONOMY AND ON THE FINANCIAL MARKET?
Authors: Samout Ammar , Raddaoui Et Amel
Published: November 2020

In this article we are interested in a current issue, namely to what extent and by what mechanisms can the COVID-19 health crisis influence the economy and the financial market. This article proposes, after having defined the concepts "the health crisis, economic crisis and financial crisis", to assess the impact of the health crisis on the economy and on the financial market. To answer this question, we have opted for a methodology that consists of reviewing the theoretical literature on the subject first, and then going on to a study of the socio-economic and financial impact of COVID-19.
COVID-19 ASSOCIADA A PANCREATITE AGUDA: UM RELATO DE CASO
Authors: Paravidino Letícia Martins , Valencia Heitor Carvalho Moulin , Barreto Letícia Oliveira , Wekid Maria Luiza Fagundes , Almeida Miguel Ribeiro , Valencia Márcia Maria Moulin
Published: November 2020

Resumo:

A infecção pelo vírus SARS-CoV-2, comumente chamado de “novo coronavírus”, foi a responsável pelo estado de pandemia instaurado desde o final do ano de 2019. A COVID-19, como é popularmente conhecida, acomete principalmente as vias respiratórias (superiores e inferiores). As manifestações clínicas mais comuns são febre, tosse, mialgia e fadiga. O paciente também pode apresentar secreção respiratória, dor de cabeça, hemoptise e distúrbios gastrointestinais como diarreia, náuseas, vômitos e hiporexia. Apesar da taxa de mortalidade do vírus não ser elevada na grande maioria da população, os indivíduos idosos, imunodeprimidos, cardiopatas, obesos, diabéticos e hipertensos, constituem o grupo de risco para a infecção pelo coronavírus. No presente estudo, relatamos o caso de uma paciente do sexo feminino, 51 anos, que apresentava como sintoma principal a dor abdominal em barra, característica de um quadro de pancreatite. Durante a internação, a paciente apresentou novos sinais e sintomas, testando positivo para COVID-19. A paciente teve alta após um longo período de internação, sinalizando a importância da equipe multidisciplinar no tratamento precoce dos indivíduos infectados pelo SARS-CoV-2. 

 

Palavras-chave: Coronavírus; Pancreatite, COVID-19, SARS-CoV-2
Hemodynamic Data Analysis and Site of Measurement in Children and Adolescents
Authors: Močnik Mirjam , Varda Nataša Marčun
Published: November 2020

Pulse wave velocity is a method of functional vascular evaluation. The gold standard is the carotid-femoral pulse wave velocity measurement. However, the software allows measurement among radial, carotid and femoral artery. The goal of our prospective pilot study was to compare pulse wave velocity measurement among different arteries, not only carotid-femoral, in children and adolescents to find out, if the measurement can be performed in a simplified version with comparable results which would be especially important in younger children. Pulse wave velocity was measured in three different ways: carotid-femoral pulse wave velocity in lying position, carotid-radial pulse wave velocity in lying position and carotid-radial pulse wave velocity in sitting position. Additionally, central hemodynamic data were collected. There was statistically significant difference between: carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity in lying position and carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity in sitting position (p < 0.0001 for both). There was no significant difference between carotid-radial pulse wave velocity in lying or sitting position (p = 0.158). Analysis of central hemodynamic data showed statistically significant differences between subendocardial viability ratio (p = 0.001), end systolic pressure (p = 0.001) and central diastolic pressure (p = 0.001) when central hemodynamic data of carotid-radial measurements lying and sitting were compared, but there were no differences when the same parameters were compared between hemodynamic data of both lying positions, except for subendocardial viability ratio. The site of measurement significantly affects pulse wave velocity and can not be interchangeable. On the contrary, the position of the child does not affect pulse wave velocity, but could be important in hemodynamic data analysis.
Deterioration effects of heat stress on farm animals performance in tropical and subtropical regions
Authors: Alsaied Alnaimy Mostafa Habeeb
Published: November 2020

The thermal comfort region for greatest animals is between 4 °C and 25 °C and when environmental temperature surpasses 25°C, animals suffer from heat stress conditions. Over 50% of the cattle population is located in the tropics and it has been appraised that heat causes severe economic loss in approximately 60% of the dairy farms around the world. In tropical and subtropical countries, the climatic characteristic is the major constraint on animal productivity. In severe heat stress, growth, milk yield, milk composition and reproductive traits are reduced as a result of the extreme changes in biological functions affected by heat stress. Heat stress disturbs the steady-state concentrations of free radicals, resulting in both cellular and mitochondrial oxidative damage. Although heat stress causes a decline in dry matter intake, the cow's energy and protein requirements in hot environments increase. This review provides an overview of the impact of heat stress on farm animals.
Significados de viver com ferida crônica: estudo de metassíntese
Authors: Araújo Wilkslam Alves de , Assis Wagner Couto , Vilela Alba Benemérita Alves , Boery Rita Narriman Silva de Oliveira , Rodrigues Vanda Palmarella , Rocha Roseanne Montargil
Published: November 2020

Objetivo: explorar pesquisas qualitativas sobre os significados de viver com ferida crônica. Método: trata-se de uma metassíntese qualitativa. Foram incluídos 13 artigos, totalizando uma amostra de 248 indivíduos que autorreportaram viver com ferida crônica. Utilizou-se o instrumento do Critical Appraisal Skills Programme para avaliação dos artigos elegíveis, e para relatar a síntese qualitativa, seguiram-se as recomendações do Enhancing transparency in reporting the synthesis of qualitative research. A análise e extração das informações e construção da síntese foram feitas por dois revisores independentes, sob o auxílio de um terceiro revisor especialista. Resultados: viver com ferida crônica envolve preocupações iniciais e aparecimento dos sintomas, especialmente dor marcante. Relatam que o aumento da dor levou à baixa capacidade funcional, bem como relações sociais e condição financeira fragilizadas. As experiências ilustram os desafios da carga emocional e das implicações do adoecimento, que contribuíram para o isolamento social. A religiosidade e espiritualidade foram as principais estratégias de enfrentamento. Conclusão: viver com ferida crônica significa uma condição de dor, limita a capacidade física e funcional, provoca sentimentos e emoções negativas que resultam no isolamento das pessoas.
Civil Society Organisations beyond the European Union: Normative Expectations and Local Realities
Authors: Buzogány Aron
Published: November 2020

This article analyses the development of the EU's external civil society agenda and how this is interpreted by various actors. Using qualitative interviews carried out in Ukraine, Georgia and Brussels, the article shows how the EU's external civil society agenda has developed in parallel with the EU's internal ‘governance turn’. Changes in this narrative from a partnership-orientated role towards a more political watchdog-role for civil society organisations are (re)interpreted differently by EU actors, EU-based civil society organisations and those in the neighbourhood countries. By focusing on localised interpretations and the inherent contradictions this policy produces, this article shows that civil society's new watchdog role is not only directed towards controlling domestic governments but also the EU.