bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing and Development of a DNA Vaccine Expressing HER2/ HER3 and CCL20 as a Novel Candidate for Breast Cancer Vaccine
Authors: Heshmatzad Katayoun , Gholamzad Amir , Gholamzad Mehrdad , Eslami Maryam
Published: March 2023

Background: Breast cancer (BC) is one of the most common diseases among women worldwide and about 2.1 million new cases were diagnosed in 2018. Despite effective treatments such as chemotherapy, radiotherapy and Hormone therapy, BC has been remained as one of the significant reasons of women ‘s death. Recent progress in the new field called as immunotherapy have changed the management of breast cancer completely and plays a major role in the efficacy improvement of BC conventional treatments. One of the significant types of Antigen-specific immunotherapy is DNA vaccine. This type of vaccine is based on designing a plasmid which can encode peptides which are important in cancer immunothrapy. In this study Bioinformatics Tools and In-silico prediction methods were used in order to select the appropriate HER2, HER3, CCL20 sequences and the standard form of the recombinant Vector(PIRES2-GFP). PIRES2-GFP transfection in to HECK 293 T cell line was carried out and its expression was evaluated by fluorescence microscope.
Reuslt: This study results indicated that plasmid containing HER2 and HER3 and CCL20 can be expressd as an fusion protein that can be used as breast cancer vaccine.
Conclusion: Cancer vaccines have led to modest effects in treatment of cancer affected patients due to immunosuppression in micro environment of Tumors. Some strategies have been taken in order to overcome this problem including Optimization of the Antigens and the combination of vaccine with other complementary therapies. The cytokine-based adjuvants such as interleukin-12 (IL-12) have been suggested as one of the most effective enhancing immune responses options.
Plant community compositional stability over 40 years in a Fraser River Estuary tidal freshwater marsh
Authors: Lane Stefanie , Shackelford Nancy A. , Bradfield Gary E. , Denoth Madlen , Martin Tara G.
Published: March 2023

Long-term data sets documenting temporal changes in vegetation communities are uncommon, yet imperative for understanding trends and triggering potential conservation management interventions. For example, decreasing species diversity and increasing non-native species abundance may be indicative of decreasing community stability. We explore long-term plant community change over a 40-year period through the contribution of data collected in 2019 to two historical datasets collected in 1979 and 1999 to evaluate decadal changes in plant community biodiversity in a tidal freshwater marsh in the Fraser River Estuary in British Columbia, Canada. We examine whether characteristic plant assemblages are consistent over time, whether alpha (α) and beta (β) diversity change within and between assemblages, and whether associated indicator species change. We found that plant assemblages were characterized by the same dominant indicator species, but most other indicator species changed, and that overall α-diversity decreased while β-diversity increased. Further, we found evidence for plant assemblage homogenization through the increased abundance of non-native invasive species such as yellow flag iris (Iris pseudacorus) and reed canary grass (Phalaris arundinacea). These observations may inform concepts of habitat stability in the absence of pulse disturbance pressures, and corroborate globally observed trends of native species loss and non-native species encroachment. Our results indicate that within the Fraser River Estuary, active threat management may be necessary in areas of conservation concern in order to prevent further native species biodiversity loss.
What factors significantly impact Chinese subjective well-being and survival? A longitudinal study using joint modelling
Authors: Qiao Xiaoyan , Nie Huilan , Chen Zhi , Lan Yifu , Zhang Han , Hao Yabin , Webb Lucy , Shi Xin
Published: March 2023

Background

Well-being is the goal that everyone and every country pursues. However, studies of the dependence between time-varying longitudinal measures of subjective well-being and survival outcomes are still scarce. The aim of this study was to conduct joint model analysis of longitudinal data and survival data to explore the influencing factors of Chinese residents' subjective well-being and survival, and to assess the impact of longitudinal dynamic measurements on survival outcomes.

Methods

Based on adult data (≥16) from the China Family Panel Studies obtained between 2010-2018, a spatiotemporal analysis of Chinese subjective well-being levels was conducted and joint modelling was used to analyze subjective well-being. In addition, the individual dynamic survival probability was predicted.

Results

In terms of the demographic characteristics, Han nationality, male, urban living, and married or cohabiting individuals are happier than non-Han, female, rural living, and being single. The older group was happier than the youth group. People with fewer children were happier. In terms of the SES, access to medical insurance, higher education, high social status, high per capita net income of households, large housing area, and ownership of other properties were protective factors for subjective well-being, while being a member in organizations was significantly negative. In terms of the living habits, smokers had worse subjective well-being than non-smokers; Physical exercise could enhance people's subjective well-being and drinking had a positive impact on subjective well-being. In terms of the health status, physical health had a positive impact on subjective well-being, while both hospitalization and chronic diseases had a negative impact on subjective well-being. As regards the survival outcomes, the study demonstrated that each unit increase in subjective well-being was associated with a 13% reduction in the risk of death.

Conclusions

In general terms, population subjective well-being in China tends to decline over time. This study aims to provide powerful evidence and decision-making support for government-level improvements to the subjective well-being of residents and prolong their lifespan.
Application of a novel improved Manhattan distance on bearing fault diagnosis
Authors: Wang Wei , Li Shaohui , Sun Yongjian
Published: March 2023

Rolling bearing is a common rotating machine in industry. Once it is damaged, the industrial machinery associated with it will be affected, and if it is serious, it may threaten life safety. Thus, an effective fault diagnosis method can reduce the occurrence of accidents. In the light of the principle of Manhattan distance and symmetrized dot pattern (SDP), the Manhattan distance is improved and a new variable is obtained. It is used as characteristic parameter to diagnose fault type. Firstly, sample data of rolling bearing under various working conditions is extracted, and it’s split into 10 pieces of data. Then, through the SDP principle, the equal part of the data is became a picture, and the symmetrical image in polar coordinate system is obtained. After binarization of the SDP image, the local area of the binarized SDP image is selected, and the mean value matrix of the local matrix is computed, and salt and pepper denoising is carried out for each local matrix and mean value matrix, and the maximum characteristic value of average value array after salt and pepper denoising is computed. Finally, local images are corresponded with their average images one by one, and the Manhattan distance between them is calculated. According to the feature method, the improved new value is obtained by linear transformation, which is called the improved Manhattan distance, and then the average value is obtained. Through the experimental data to verify whether the method can effectively distinguish the fault type.
Difficult-to-treat TAFRO syndrome associated with Sjögren’s syndrome successfully treated with Dual B cell depletion therapy: A case report
Authors: Watanabe Mitsuru , Okada Masato , Haji Yoichiro , Kato Mizuki , Ito Takanori , Amari Yui , Mizuno Yukina , Hozumi Mirai
Published: March 2023

TAFRO syndrome is a systemic inflammatory disease of unknown etiology. It is characterized by thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. Herein, we report the case of a 60-year-old male with TAFRO syndrome. A few weeks after the patient developed an intermittent fever, he presented to our hospital with diarrhea, abdominal distension, and whole-body edema (face, extremities, and abdomen). Autoantibody and lip biopsy findings supported the diagnosis of primary Sjögren’s syndrome (pSS). High-dose steroids and tocilizumab were used to treat his refractory thrombocytopenia and ascites. However, systemic inflammation and renal dysfunction did not improve, resulting in temporary hemodialysis. Eventually, dual B-cell depletion therapy with rituximab and belimumab ameliorated the patient’s symptoms. About 16 weeks after discharge, the patient’s overall condition had improved. The TAFRO syndrome may be a severe manifestation of pSS. Considering the immunological context, B cell-targeted therapy provides new insights into improving this life-threatening disease and enables rapid steroid tapering.
A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review
Authors: Upadhyay Sonal , Bhushan Ravi , Pandey Vivek , Tripathi Anima , Sahu Alakh N. , Rani Anjali , Diwakar Amita , Gupta Rashmi , Dubey Pawan K.
Published: March 2023

Uterine fibroids (UFs) or leiomyoma is the most common gynaecological disorder affecting 70% of premenopausal women and one of the leading causes of infertility. To date, there is no specific therapy available except surgical intervention including hysterectomy or myomectomy. However, to manage UFs, lot of high cost medications are prescribed although they have serious side effects on women’s reproductive health. Recently an increasing trend has been seen on consuming dietary phytochemicals to control diverse gynaecological ailments. This review's goal is to provide a summary of the knowledge that is currently available regarding the mechanisms of action of various botanical medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (Dehydroxyelephantopin, Butein, Capsaicin, Fisetin, Kaempferol, Resveratrol, Silibinin and Curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setup through modulating various signalling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of ULM. This review provides key molecular insights for development of phytochemical based novel personalized therapy for non-surgical management of ULMs which may help to avoid hysterectomy.
Open parotid gland biopsy under combined superficial cervical plexus and auriculotemporal nerve block
Authors: Mourouzis Constantinos , Panagiotopoulos Theodoros , Rallis George
Published: March 2023

Purpose
In high-risk patients often regional anaesthesia is more preferable and easier to perform compared to general anaesthesia. In this case report we evaluate the efficacy of combined superficial cervical plexus block and auriculotemporal nerve block in an open parotid gland biopsy.
Methods
Under combined superficial cervical plexus block and auriculotemporal nerve block we performed an open parotid gland biopsy in a patient who suffered from severe systemic problems posing high risk for general anaesthesia.
Results
The operation was uneventful, the duration of anaesthesia and analgesia until the first analgesic request were satisfactory.
Conclusion
It can be concluded that the combination of a regional anaesthesia technique with a superficial cervical plexus nerve block and auriculotemporal block is an alternative and safe technique for patients with parotid gland tumours requiring biopsy for setting a diagnosis.
Uncommon Presentation of Meningococcal Pneumonia in Vietnam: A Case Report
Authors: Trong Thang Khong , Nguyen Tung Phi , Nguyen Nam Ngoc Phuong , Vu Hoai Thi Thu , Nguyen Khanh Phuong Hoang
Published: March 2023

This is a case report of an elderly male patient who was diagnosed with meningococcal pneumonia resulting in respiratory failure. The patient had pre-existing conditions of chronic obstructive pulmonary disease (COPD) and prostate cancer. Upon admission, the patient exhibited symptoms such as a purulent cough producing sputum, dyspnea, decreased oxygen saturation, and chest X-ray images that were consistent with pneumonia. The bacteria responsible for the infection was identified as Neisseria meningitidis through bacterial culture, which was found to be antibiotic-resistant. The patient did not show any signs of septicemia or meningitis. Treatment was initiated with an appropriate antibiotic regimen, and the patient was discharged after demonstrating improvement over 10 days. Close contacts of the patient were given prophylactic antibiotics, and no secondary infections were recorded. In this article, we will present a detailed case report, and provide an overview of the epidemiology of meningococcal infections in Vietnam, as well as summarizing the clinical characteristics of meningococcal pneumonia cases globally.
Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: Relevance for their antitumor activity
Authors: Bosca Lisardo , Povo-Retana Adrián , Fariñas Marco , Landauro-Vera Rodrigo , Mojena Marina , Alvarez-Lucena Carlota , Fernández-Moreno Miguel , Castrillo Antonio , Rosa Juan de la , Sánchez-García Sergio , Foguet Carles , Mas Francesc , Marin Silvia , Cascante Marta
Published: March 2023

In recent years, the central role of cell bioenergetics in regulating immune cell function and fate has been recognized, giving rise to the interest in immunometabolism, an area of research focused on the interaction between metabolic regulation and immune function. Thus, early metabolic changes associated with the polarization of macrophages into pro-inflammatory or pro-resolving cells under different stimuli have been characterized. Tumor-associated macrophages are among the most abundant cells in the tumor microenvironment; however, it exists an unmet need to study the effect of chemotherapeutics on macrophage immunometabolism. Here, we use a systems biology approach that integrates transcriptomics and metabolomics to unveil the immunometabolic effects of trabectedin (TRB) and lurbinectedin (LUR), two DNA-binding agents with proven antitumor activity. Our results show that TRB and LUR activate human macrophages toward a pro-inflammatory phenotype by inducing a specific metabolic rewiring program that includes ROS production, changes in the mitochondrial inner membrane potential, increased pentose phosphate pathway, lactate release, TCA cycle, serine and methylglyoxal pathways in human macrophages. Glutamine, aspartate, histidine, and proline intracellular levels are also decreased, whereas oxygen consumption is reduced. The observed immunometabolic changes could explain additional antitumor activities of these compounds and open new avenues to design therapeutic interventions that specifically target the immunometabolic landscape in the treatment of cancer.
Radiologic and histopathology features of follicular dendritic cell sarcoma in the stomach and abdominal cavity: a case report
Authors: zhan ting , xing shanshan , lu chunhua
Published: March 2023

It is highly uncommon for the gastrointestinal tract to be affected by follicular dendritic cell sarcoma(FDCS), a rare mesenchymal tumor that typically develops in the lymph nodes. Here, we describe a 64-year-old woman who discovered a lump in her left upper abdomen six months ago and was just taken to the hospital due to excruciating abdominal pain. An abdominal CT scan shows a soft tissue mass around the cardia. The patient underwent “radical total gastrectomy and esophagojejunostomy (Roux-Y anastomosis)”. Immunohistochemical and postoperative histopathology results were compatible with FDCS. The pathogenic characteristics of FDCS have received substantial discussion in the literature, however, the imaging characteristics of FDCS that involves the stomach and abdominal cavities have received less attention. This case report aims to enhance clinicians' understanding and diagnosis of dendritic cell sarcoma in the stomach and abdominal cavities of abdominal follicles and reduce the rate of clinical misdiagnosis.
Knowledge-Graph Based Multi-Domain Model Integration Method for Digital-Twin Workshops
Authors: Wang Xiangdong , Hu Xiaofeng , Ren Zijie , Tian Tianci , Wan Jiafu
Published: March 2023

The digital twin workshop is a new workshop operation paradigm that enables precise decision-making by fusing virtual and physical space. As a complex manufacturing system, the digital twin model of the workshop must integrate models from different domains in order to provide personalized services. The interoperability of multi-domain models and the dynamic update of parameters become obstacles. In this paper, a knowledge graph (KG)-based multi-domain model integration method for digital twin workshops is proposed. The multi-domain model integration architecture based on KG is consisted of model element, model ontology, model data, semantic integration and network connection. Then, the KG of multi-domain model for design, manufacturing and simulation is constructed through ontology modeling and knowledge extraction. On this basis, multi-domain model integration is realized through semantic inference and knowledge query. The model parameters are updated through file exchange during the dynamic simulation. Finally, multiple scenarios in the subassembly workshop for hull construction are used to verify the efficacy of the proposed method. During the assembly and welding of hull parts, the integration of the product model, equipment model, and simulation model is realized, which assists in meeting the service requirements of multiple business scenarios.
Dietary Diversity Practice and its associated factors among Adult People Living with HIV who go to health facilities in Ilu Abbabor Zone, South West Ethiopia: a facility-based cross-sectional study
Authors: negera ebissa , Belachew Tefera , Hassan Kalkidan
Published: March 2023

Introduction: Patients with HIV/AIDS are at high risk of consuming low-quality, monotonous food. The current study aimed to assess dietary intake adequacy and its associated factors among adult ART patients in Ilu Abbabor Zone, South West, Ethiopia. Methods: A facility-based cross-sectional study was conducted in six different health care facilities. Epi-Data was used for data entry, and SPSS version 21 was used for analysis. The level of significance in the final model was set at (P < 0.05). Results: The current study found that the majority of respondents (61.2%) had an inadequate dietary diversity practice. Adults on ART, on the other hand, have adequate dietary diversity practice. On the other hand, dietary diversity practice of adult people on ART, significantly associated with; being ever married [AOR = 0.366; 95% CI: (0.211, 0.634)], household number >/=5 [AOR = 2.45; 95% CI: (1.522, 4.088)], clinical stage of disease [AOR = 2.474; 95% CI (1.124, 5.444), and obesity [AOR = 0.290; 95% CI: (0.099, 0.846)]. Conclusions: The vast majority of study subjects (61.2%) had an inadequate dietary diversity practice. Furthermore, the adequacy of adult ART dietary intake was significantly related to marital status, household number, clinical stage of disease, and nutritional status. As a result, unmarried adult people living with HIV/AIDS must receive care and support. It is strongly advised to integrate nutrition with RH services, particularly family planning. Finally, early HIV/AIDS diagnosis and management, as well as nutrition, are critical for delaying the rapid progression of HIV to Acquired Immune Deficiency Syndrome (AIDS).
Catalytic activity of phenol oxidation over iron and cooper-exchanged pillared bentonite
Authors: CHELLAL Khalida , HAMIDOUCHE Fahim , Naima BOUDIEB , MEGUELLATI Zineb , TRARI Mohamed
Published: March 2023

Al, mixed Al-Fe and Al-Cu pillared clays were prepared. The solids were characterized by X-ray diffraction (XRD), N2 adsorption and H2-TPR. The dispersion of the cold clay suspension, before the pillaring, increases the basal spacing and the specific surface area. CWPO of phenol under mild conditions (25 °C, 1 atm) was carried out without correction of pH. Mixed Al-Fe and Al-Cu pillared clays have comparable performances, although they showed some differences in the H2O2 decomposition kinetics. A total conversion of H2O2 is obtained without the complete phenol conversion over mixed Al-Fe pillared clays suggesting the presence of active species in these catalysts. In a slight excess of H2O2, the activity increased for all iron-based clays catalysts with the increase in Fe content. A total conversion of phenol is obtained after 15 h of reaction over Fe/MR-AlFe(10) and after extending the reaction time to 30 h in the presence of Fe/MR-Al. While MR-AlFe(10) only converted 57.12% under the same conditions. MR-AlFe(10) has the greater basal space (17.44 Å) and is more active for H2O2 decomposition than Fe/MR-Al, which certainly allowed greater accessibility of the reactant to the iron species. Iron exchanged and post-pillared clay with mixed (Al-Fe) solution containing 10% of iron expressed as molar percentage {Fe/MR-AlFe (10)} was the most efficient for this reaction combining good catalytic activity with high stability against iron leaching (0.02%). It showed a total phenol degradation, the highest H2O2 decomposition (85.7%) and more than 80% of TOC removal after 15 h of reaction.
WITHDRAWN: Developing a novel cylindrical dielectric resonator antenna fed by microstrip line for millimeter-wave applications
Authors: Hasnaoui Yassine El , Mazri Tomader
Published: March 2023

The current work presents a novel cylindrical dielectric resonator (CDR) antenna geometry operating at 28 GHz for fifth-generation wireless communication networks (5G). Because of its high radiating power factor, the used dielectric resonator is regarded as a promising new candidate in the field of antennas. The CDR antenna is made up of a FR4 Epoxy Resin substrate with a relative permittivity of 4.4 and a height of 1.8 mm, to which we added a dielectric resonator with a relative permittivity of 8.3, a height of 1.5 mm and a radius of 1.34 mm and it fed by a single microstrip line. The designed antenna geometry was simulated and optimized with the electromagnetic solver HFSS, and the results were validated with the CST microwave studio software. The results allowed us to obtain an antenna radiation at the desired frequency of 28 GHz with an interesting return loss value, a good radiation pattern, a high gain, a large bandwidth and a high directivity. As a result, this antenna is suitable for a wide range of wireless satellite applications.
Impact of Pension Income on Healthcare Utilization of Older Adults in Rural China
Authors: Yan Peizhe , Li Fenghang , Nicholas Stephen , Maitland Elizabeth , Tan Jialong , Chen Chen , Wang Jian
Published: March 2023

OBJECTIVE
In China, rural residents experience poorer health conditions and a higher disease burden compared to urban residents but have lower healthcare services utilization. Rather than an insurance focus on enhanced healthcare services utilization, we focus on an income shock, in the form of China’s New Rural Pension Scheme (NRPS), on outpatient, inpatient and discretionary over-the-counter drug utilization by over 60-year-old rural NRPS residents.
METHODS
Providing a monthly pension of around RMB88(USD12.97), NRPS covered all rural residents over 60 years old. Fuzzy regression discontinuity design (FRDD) was employed to explore the NRPS causal effect on healthcare services utilization, measured by outpatient and inpatient visits and discretionary over-the-counter drug purchases. The nationwide China Health and Retirement Longitudinal Study (CHARLS) 2018 provided the data.
RESULTS
Without significant changes in health status and medication needs, 60-plus-year-old NRPS recipients significantly increased the probability of discretionary drug purchases by 33 percentage points. NRPS had no significant effect on the utilization of outpatient and inpatient utilization. The increase in the probability of discretionary drug purchases from the NRPS income shock was concentrated in healthier and low-income rural residents. Robustness tests confirmed that FRDD was a robust estimation method and our result is robust.
CONCLUSION
NRPS was an exogenous income shock that significantly increased the probability of discretionary over-the-counter drug purchases among over 60-year-old rural residents, but not the utilization of inpatient or outpatient healthcare services. Income remains an important constraint for rural residents to improve their health. We recommend policymakers consider including commonly used over-the-counter drugs in basic health insurance reimbursements for rural residents; provide health advice for rural residents to make discretionary over-the-counter drug purchases; and to mount an information campaign on over-the-counter drug purchasing in order to increase the health awareness of rural residents.
The combination of subclonal and clonal TP53 and KRAS alterations and poor response to first line therapy identifies ultra-high-risk patients with pediatric T-lymphoblastic leukemia (T-ALL)
Authors: Kempter Tamara , Richter-Pechanska Paulina , Michel Katarzyna , Rausch Tobias , Erarslan-Uysal Busra , Eckert Cornelia , Zimmermann Martin , Stanulla Martin , Schrappe Martin , Cario Gunnar , Köhrer Stefan , Kirschner-Schwabe Renate , Korbel Jan , Kunz Joachim , Kulozik Andreas
Published: March 2023

It has been the hypothesis of this study that clonal or subclonal variants of TP53 and KRAS that signify ultra-high risk in relapsed pediatric T-ALL indicate a poor prognosis at initial disease. We analyzed two cohorts of 160 and 226 BFM-patients, one consisting of 81 patients who later relapsed and 79 matched non-relapsing controls. Cohort-2 consisted of consecutive patients of whom 30 relapsed. In cohort-1 targeted sequencing revealed TP53 clonal and subclonal variants in 6/81 relapsing but in none of the non-relapsing patients (p=0.014). KRAS alterations occurred in 9/81 relapsing and 2/79 non-relapsing patients (p=0.032). No relapsing patient with TP53 and/or KRAS alterations survived, whereas 19/67 relapsing patients without such variants did (p=0.023). In cohort-2, 196 patients without relapse included 10 with TP53 or KRAS variants, all of whom were non-high risk based on treatment response. However, in the entire group of 386 patients the 188 patients with poor treatment response included 9 with such a variant of whom 8 relapsed and died. Of these, 5 had not undergone stem-cell-transplantation. In conclusion, these data show that subclonal and clonal TP53 and KRAS alterations at initial diagnosis indicate a dismal prognosis in children with T-ALL and poor treatment response.
Investigation of the stability and gastrointestinal digestion of camellia oleifera oil bodies as a natural delivery system for curcumin
Authors: Huang Zi-Wei , wu xuehui , lan xiaohe , zhang bing
Published: March 2023

We extracted Camellia oleifera oil bodies (COOB) from Camellia oleifera seeds (COS) to evaluate the function of oil bodies in delivering lipophilic bioactive compounds. Curcumin was loaded into COOB by pH shift method to form Curcumin-Camellia oleifera oil body emulsion (COB). Characterization analysis of COB with different mass fractions showed that COB had the best encapsulation efficiency (80.56%), particle size (2.17 μm), and environmental stress, could show excellent stability at salt concentrations from 100 to 500 mmol/L or pH values of 3 and 5 to 9 and at different temperature treatments when the addition of curcumin was 1%. Based on the digestion of COB in the gastrointestinal tract, a stable and sustained release of the active substance and, ultimately, a bioavailability of 81.51% of curcumin and 37.33 μmol/ml of free fatty acids were obtained in COOB carriers, which indicated COOB has the potential as a natural delivery system for lipophilic bioactive compounds.
Juxtaglomerular cell tumor：how to identify this rare disease by ultrasound?
Authors: Wang Li , Li Meiying , Jin Siqi , Ouyang Yunshu , Wang Fenglan , Lv Ke , Li Jianchu , Jiang Yuxin , Liu He , Zhu Qingli
Published: March 2023

Purpose：To study the value of ultrasound in the diagnosis of juxtaglomerular cell tumor (JGCT).
Methods: From January 2005 to July 2020, fifteen patients diagnosed as JGCT by surgical pathology in Peking Union Medical College Hospital were collected. All patients underwent preoperative ultrasound examination. The clinical, laboratory, ultrasound, computed tomography (CT), surgical, and pathological features of the patients were analyzed retrospectively.
Results: The 15 patients were 5 males and 10 females with a median age of 29 years (10~72 years). 14 of them had hypertension and one had normal blood pressure. The tumors were all solitary, with a median diameter of 1.5 cm (0.9-5.9 cm). Among the fifteen patients, eleven were corrected detected by preoperative ultrasound, and four were missed. There was a significant difference in tumor size (2.64±1.48 cm vs. 1.23±0.21 cm) and whether the tumor protruded outward (9/11 vs. 0/4) between the ultrasound-detected group and the ultrasound-missed group (p=0.010, p=0.011). Of the 11 tumors detected by ultrasound, four were extremely hypoechoic, two were hypoechoic, three were isoechoic, and two were hyperechoic. Color Doppler showed no blood flow in five tumors no more than 2cm, and mild blood flow in six tumors more than 2cm.
Conclusions: JGCT is rare, and has characteristic clinical manifestations. Diagnosis should be suspected in case of secondary hypertension, particularly in young women, if no renal vascular cause is found. Ultrasound, combined with clinical manifestations, was helpful for the diagnosis.
A novel image encryption scheme combing optical chaos scrambling, DNA diffusion strategy and MOPSO algorithm
Authors: Xiao Tao , Li Qiliang , Bai Haoruo
Published: March 2023

A secure encryption scheme, combining multi-objective particle swarm optimization (MOPSO), optical chaos, and DNA algorithm is proposed and demonstrated. In this paper, a secure encryption and decryption architecture based on optical chaotic synchronization system with injection-locking is analyzed. We prove that a main laser (ML) can drive two-pair secondary lasers (TPSLs) to generate the synchronized optical chaos with high complexity. The system employs the XOR operation between the Hash value of the initial image and optimized value by MOPSO, which modulates the bias current of ML, thus TPSLs are driven to generate two pair synchronized chaotic sequences, which combine the Hash value of the initial image to generate two keys through a certain algorithm. Furthermore, two keys are used to scramble the pixel positions of the image and diffuse image pixels through DNA rules, and then in receiving end, two same keys are used to unscramble and reversely diffusethe encrypted image. Besides modulating the bias current of ML, the other aim of MOPSO is to optimize the entropy of the encrypted image and the correlation between the adjacent pixels. In order to ensure the recovery of real image, we compute and compare the digest-message of two pair synchronized chaotic sequences by using Hash algorithm in two ends before transmitting the encrypted image over optical fiber link. By synchronizing with the lasers at the sending end, we obtained two same keys to decrypt the ciphertext image in the receiving end. The simulation results show that this scheme can achieve secure communication of image against various attacks by analyzing and testing the security of the encrypted image.
Shade canopy density variables in cocoa and coffee agroforestry systems
Authors: Somarriba Eduardo , Saj Stéphane , Orozco-Aguilar Luis , Somarriba Aurelio , Rapidel Bruno
Published: March 2023

An estimated 3.41 million hectares of cocoa and 8.08 million hectares of coffee are cultivated under shade trees i.e. in agroforestry systems. Shade canopies are usually characterized in terms of tree density (N, trees ha-1), tree basal area (G, m2 ha-1) and percent canopy cover (%C). This article shows that these variables have cross-compensation effects that reduce their capacity to inform on the shading conditions in the understory. Density and basal area are not directly related to canopy cover (and hence to shading) and need additional assumptions about both tree size and species-specific allometric relationships between stem diameter and crown diameter. This article explores the compensatory effects between these variables and uses simulations with the software ShadeMotion (www.shademotion.net) to show how 24 different, simple, even-sized, mono-layered, Cordia alliodora shade canopies with constant N, G and %C display significantly different shade levels and temporal patterns of shading depending on tree stem and crown diameters, tree height, spatial planting configurations (square, random and alleys) and leaf fall patterns. A minimum set of variables capable of providing a more informative description of the shading characteristics of a cocoa or coffee shade canopy is proposed. Findings in this study can shed light on the current, heated debate on the pros and cons of definitions of cocoa agroforestry used by chocolate companies, governments, certification companies, NGOs, and donors, especially in West and Central Africa. In this article, emphasis is given to cocoa, but the analysis, results and conclusions are equally applicable to coffee agroforestry systems.
Barriers to and facilitators of advance care planning implementation for medical staff after the coronavirus disease 2019 pandemic: An overview of reviews
Authors: Inokuchi Ryota , Hanari Kyoko , Shimada Kensuke , Iwagami Masao , Sakamoto Ayaka , Sun Yu , Mayers Thomas , Sugiyama Takehiro , Tamiya Nanako
Published: March 2023

Background:The coronavirus disease 2019 (COVID-19) pandemic has impacted the capacity for advance care planning between patients, families, and healthcare teams. The barriers to and facilitators of advance care planning vary with settings. This study sought toidentify and review the barriers to and facilitators of advance care planning implementation for medical staff in different settings (e.g., hospitals, outpatients, care and nursing homes) during the COVID-19 pandemic.Methods:This study followed an overview of review design and was registered in the International Prospective Register of Systematic Reviews (CRD42022351362).A search of MEDLINE, CENTRAL, Web of Science, and Embase databases was performed through November 14, 2022. AMSTAR 2 was used to assess the risk of bias.Results:The final analyses included seven studies. Common barriers to advance care planning implementation included visitation restrictions, limited resources and personnel, and lack of coordination among health professionals. In care and nursing homes, the lack of palliative care physicians and the psychological burden on staff were identified as barriers. Using telemedicine for information-sharing was a common facilitator. In hospitals, facilitators were short-term training in palliative care and palliative care physicians joining the acute care team; in care homes and nursing homes, they were advance care planning education and emotional support for staff.Conclusions:Although inadequate staff education regarding advance care planning in hospitals and facilities and the lack of community-level information-sharing have long been noted, the pandemic highlighted these issues. Short-term training programs for staff and immediate information-sharing could facilitate advance care planning.
Scattering of Free Electrons with Hydrogen Atoms in Proton Exchange Membrane Fuel Cell System
Authors: Dhobi Saddam Husain , Gupta Suresh Prasad , Nakarmi Jeevan Jyoti , Koirala Bibek , Yadav Kishori , Oli Sharad Kumar , Gurung Milan
Published: March 2023

The objective of this work is to study the Klein-Nishina (KN) cross section during the collision of free electrons and atoms (H-atom and Pt-atom) near the cathode of Proton Exchange Membrane Fuel Cell (PEMFCs). The developed KN cross section was computed using MATLAB shows KN cross section decrease with an increase with the temperature. The maximum KN cross section recorded for single scattering is about -70.2m2 and -66m2 in natural log terms during the collision of free electrons with H-atom and Pt-atom, respectively. The maximum KN cross section recorded for 1ml flow of hydrogen is about -26.6m2 and -22.25m2 in natural log term during the collision of free electrons with H-atom and Pt-atom, respectively.
İDARİ DAVALARDA EŞİTLİK DENETİMİNİN YOĞUNLUĞU
Authors: KESKİN Züleyha
Published: March 2023

Eşitlik ilkesi, temel bir ilke ve hak normu olarak idarenin yargısal denetiminde önemli bir yer tutmaktadır. Yargısal denetim yoğunluğu, idari yargı yetkisinin sınırlarına göndermede bulanan ve idari dava konusunun nasıl ve ne kadar denetlendiği ile ilgili bir kavramdır. Denetimin yoğunluğunu maddi denetim ölçütleri, usuli yetkiler ve kanıt standardı belirler. Eşitlik ilkesinin denetim ölçütü olarak kullanıldığı davalarda denetim yoğunluğu, belirli bir dava konusuna ve sınıflandırmaya bu hususlar göz önüne alınarak hangi düzeyde bir denetim uygulanacağına bağlıdır. İdari davalarda eşitlik denetimin yoğunluğunun bilinmesi, yargısal denetiminin belirliliği ve öngörülebilirliği açısından önemlidir. Eşitlik ilkesinin benzer davalarda tutarlı bir şekilde uygulanması, mahkemelerin ‘duruma göre’ davranmasını engellediği gibi kişi hak ve özgürlüklerinin en üst düzeyde korunmasını da sağlar. Bu çalışma, eşitlik ilkesinin norm yapısını ve kapsamı ile birlikte yargıç yetkilerini dikkate alarak idari davalarda eşitlik denetiminin yoğunluğunu ortaya koymayı amaçlamaktadır. Çalışma, özellikle kural-ilke ayrımına ve eşitlik ilkesinin kapsamına odaklanarak eşitlik testinin idari davalarda ne kadar etkili kullanılabileceğini göstermeye çalışmaktadır
Indirect determinants of online purchase decisions: A case study of different generations in Peru
Authors: Zirena-Bejarano Patricia , Myreyle Chávez Zirena Elbia , De La Gala Velasquez Bernardo
Published: March 2023

This study aims to analyze the mediation effect of subjective norms and perceived behavioral control on the linkage between online consumer attitude and online purchase decisions of generation X, generation Y (millennials), and generation Z (centennials) in developing countries, particularly Peru. This empirical investigation surveyed 121 respondents of generation X, 200 millennials, and 200 centennials in Peru. The data were processed through structural equation modeling approach. This study demonstrates that online consumer attitude positively and significantly influences online purchase decisions; this relationship is enhanced through the mediation effect of subjective norms and perceived behavioral control. Furthermore, the results indicate that the effect of the proposed variables is improved progressively in each generation, showing a greater willingness of centennials to purchase online, followed by millennials and generation X. This study assessed online consumer attitudes of different generations in Peru toward the online purchase decisions and the mediation effect of subjective norms and perceived behavior control on the mentioned relationship, which showed improved results when incorporated into a single model.
AcknowledgmentsThe authors thank the Universidad Nacional de San Agustín de Arequipa for supporting this project.
Training of Adding Turmeric and Curcuma as Food Additives for Laying Hens
Authors: Fitriani Ika Nur , Kholidah Kholidah , Hafshah Mutista , Hashona Achmad Hasmy
Published: March 2023

The use of bioactive plants to replace antibiotics is now widely used. The program's purpose is to provide a solution for natural feed additives to laying hens in Ngaliyan as a substitute for Antibiotics Growth Promotor (AGP), which is prohibited by the government, and provide knowledge to farmers about the use of medicinal plants to improve the productivity of livestock. The target was laying hens farmers in Ngaliyan. The problem was chicken feed is made without AGP and egg prices fell while feed prices had risen. The solution offered to the partner was adding food additives from turmeric and Curcuma. Turmeric and Curcuma will improve immunity to increase livestock productivity, feed efficiency, and egg quality. Based on this reason, we conducted community services for laying hens farmers in Ngaliyan. Community service activities were carried out using the PAR method for two months through socialization, training, assistance in providing additional natural feed, and evaluation. Giving turmeric and Curcuma flour can improve the quality of eggs. The result of the community service showed an understanding of partners to formulate and produce feed additives in raising laying hens was improved. In addition, farmers were able to formulate and produce herbal feed based on requirements.
Creating Santripreneurs: Empowerment of Jepara Santri in Entrepreneurship with 3D-Based Furniture Design Training
Authors: Abdullah Shodiq , Ratnawati Zulfa , Hadi Nor
Published: March 2023

As technology developed, santri in Jepara started a furniture business with the skills gained when learning in Pesantren (Islamic boarding schools), studying (nyantrik) and training. This training aims to equip students with the skills to design 3D furniture to support their businesses. The training is carried out in two stages: 1) the preparation stage, selecting interested potential participants who have the motivation and potential to set up a furniture business; 2) the implementation stage with lecture, practice, question and answer methods and simulations. The results of the training show that; 1) Santri in Jepara is very interested in the furniture business, so they are excited and could learn 3D furniture design faster; 2) After attending the training, the students are able to: a) operate the SketchUp  program and can make simple furniture designs, b) develop furniture designs with various shapes, and some have tried to make carving designs, c) have a great enthusiasm to develop expertise in the furniture business by self-learning through social media.
Positive Self-Talk Intervention to Decrease Stress in Parents of Children with Special Needs
Authors: Rohmah Prilia Zulfatur , Hidayati Diajeng Laily , Aisha Maulita Noor , Purwandari Eny
Published: March 2023

The caregiving experience of parents of children with special needs (CSN) can be challenging and can lead to significant stress and negative impacts on mental health. To address this issue, a community service activity was implemented to provide positive self-talk training to 25 parents of CSN who are members of the Indonesian Special Family Forum (FORKESI) in South Sumatra. The training was conducted online using the Zoom Meeting platform and employed the Asset Based Community Development (ABCD) method. The results of the community service indicated that the average stress levels of the participants decreased after participating in the training. Additionally, participants reported feeling more grateful for the condition of their children, more accepting of their children's condition, and having more open minds. These findings suggest that positive self-talk training is an effective strategy for reducing stress in parents of children with special needs and may have broader implications for supporting caregivers in the community.
Kiai as the Activator for Accelerating the Implementation of Child-Friendly Pesantren Based on the Local Wisdom
Authors: Mubarok Zaki , Zakiyah Zakiyah , Khofifah Ani
Published: March 2023

This service is done to accelerate the implementation of child-friendly Islamic boarding schools in Tegal Regency which has come to the piloting stage or as prospective models. The service method is Participatory Action Research (PAR) whose process aims at learning in overcoming problems and meeting the practical needs of the pesantren by identifying problems, evaluating and exploring potential in accelerating the implementation of child-friendly pesantren. The output of the community service is that the Kiai and the management of the pesantren understand the laws and regulations regarding child protection and various types of child abuse that must be avoided, propose a Regent's Regulation as a follow-up to the Regional Regulation on Facilitation of Pesantren Development, strengthen the governance of pesantren for the creation of child-friendly pesantren, cooperate with various related parties for socialization and counseling related to child-friendly pesantren, and design a pesantren curriculum with standard student behavior.
Semantic Analyses of Open-Ended Responses From Professional Development Workshop Promoting Computational Thinking in Rural Schools
Authors: Gillenwaters Amber , Iqbal Razib , Piccolo Diana , Davis Tammi , Franklin Keri , Cornelison David , Martinez Judith , Homburg Andrew , Cottrell Julia , Page Melissa
Published: March 2023

The development of curriculum and access to educational resources related to applied computing is lacking for students in K-12 schools particularly in rural areas, despite the large and growing demand for computing skills in the job market. Motivated by this need, an interdisciplinary professional development workshop was designed to promote computational thinking and curriculum integration among teachers involved in teaching core curricula including writing, math, science, and social studies in grades 3-8 in a rural midwestern state in the USA, as part of a longitudinal grant-funded program. Open-text feedback was collected before, during, and immediately after the workshop in response to multiple types of formative assessments. In this paper, we present several forms of data representation from exploratory textual analyses based on the feedback collected from the workshop participants. Semantic analysis tools including sentiment analysis and thematic analysis facilitated the identification of common themes in perception among grade 3-8 teachers relating to the implementation of computational concepts in their classrooms. Results suggest that these techniques can be useful in evaluating open-ended feedback to represent patterns of response which may aid in the identification of actionable insights related to adult learner perceptions, including interest and self-efficacy.