bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of Radiation Exposure for Various Flights from Athens International Airport
Authors: Tezari Anastasia , Stassinakis Argyris N. , Makrantoni Panagiota , Paschalis Pavlos , Alexandridis Dimitris , Gerontidou Maria , Mavromichalaki Helen , Karaiskos Pantelis , Crosby Norma , Dierckxsens Mark
Published: January 2024

In recent decades, the exposure of aviation crews and passengers to cosmic radiation has been progressively increasing due to the growing need of flights. Therefore, there is a need for radiation assessment software tools to act as a complement to other radiation protection techniques and countermeasures. In this work, the exposure to cosmic radiation is estimated for flights from Athens International Airport to various international destinations, by performing Monte Carlo simulations with the validated tool DYASTIMA/DYASTIMA-R. The results of the estimated total ambient dose equivalent, as well as the ambient dose equivalent rate for different flights, applying a typical flying level and constant atmospheric conditions, are presented for the first time. This study is carried out for different phases of solar activity for the time period from 1996 to 2019, which includes the two recent Solar Cycles 23 and 24.
Quantification of Shortwave Surface Albedo Feedback Using a Neural Network Approach
Authors: Diaz Garcia Diana Laura , Huang Yi
Published: January 2024

Radiative transfer is a nonlinear process. Despite this, most current methods to evaluate radiative feedback, such as the kernel method, rely on linear assumptions. Neural network (NN) models can emulate nonlinear radiative transfer due to their structure and activation functions. This study aims to test whether NNs can be used to evaluate shortwave radiative feedbacks and to assess their performance. This study focuses on the shortwave radiative feedback driven by surface albedo. An NN model is first trained using idealized cases, simulating truth values from a radiative transfer model via the partial radiative perturbation method. Two heuristic cases are analyzed: univariate feedback, perturbing the albedo; and bivariate feedback, perturbing the albedo and cloud cover concurrently. These test the NN’s ability to capture nonlinearity in the albedo–flux and albedo–cloud–flux relationships. We identify the minimal NN structure and predictor variables for accurate predictions. Then, an NN model is trained with realistic radiation flux and atmospheric variable data and is tested with respect to its predictions at different order levels: zero-order for the flux itself, first-order for radiative sensitivity (kernels), and second-order for kernel differences. This paper documents the test results and explains the NN’s ability to reproduce the complex nonlinear relationship between radiation flux and different atmospheric variables, such as surface albedo, cloud optical depth, and their coupling effects.
Comparison of Atmospheric Ionization for Solar Proton Events of the Last Three Solar Cycles
Authors: Maurchev Eugene A. , Shlyk Nataly S. , Dmitriev Alexey V. , Abunina Maria A. , Didenko Kseniia A. , Abunin Artem A. , Belov Anatoly V.
Published: January 2024

Numerical modeling of primary cosmic ray protons’ transport through the Earth’s atmosphere was performed for the energy spectra of solar energetic particle events (SEPs). Several events in the last three solar cycles were considered. A comparative analysis of the characteristics of coronal mass ejections and primary proton fluxes was carried out. The main results were quantitative estimates of the calculated atmospheric ionization count rate for a wide range of altitudes (from sea level up to 98 km). The difference in the influence of solar protons on the Earth’s atmosphere is considered for seven SEPs divided into three groups with similar solar sources (X-flare magnitude and coordinates) but with different characteristics of accelerated particle fluxes. The data obtained in this work are very important for future studies of radio wave propagation, atmospheric chemistry and climate change.
Assessing Nowcast Models in the Central Mexico Region Using Radar and GOES-16 Satellite Data
Authors: Islas-Flores Diana , Magaldi Adolfo
Published: January 2024

In this study, the nowcast models provided by the Python pySTEPS library were evaluated using radar derived rain rate data and the satellite product Split-Window Difference (SWD) based on GOES-16 data, focusing on central Mexico. Initially, we obtained a characterization of the rainfall that occurred in the region using the radar rain rate and the SWD. Subsequently the nowcasts were evaluated using both variables. Two nowcast models were employed from pySTEPS: Extrapolation and S-PROG. The results indicate that average SWD is below 2.5 K, 90 min before the onset of rainfall events, and, on average, the SWD is 2 K during rainfall events. The results from both nowcast models were accurate and produced similar results. The nowcasts performed better when SWD data were used as input, having an average Probability of Detection (PoD) above 70% and a False Alarm Rate (FAR) reaching 40% for the 15-min prediction. The nowcasts were less accurate using the radar rain rate as input for the 15-min forecast, where the PoD was maximum 70% and FAR reaching 40%. However, these nowcasts were more reliable during well-organized precipitation events. In this work, it was determined that the nowcast models provided by pySTEPS can provide valuable rain forecasts using GOES-16 satellite and radar data for the central Mexico region.
Computational Fluid Dynamics Analysis of Wet Dust Removal in High-Gravity Countercurrent Rotating Packed Bed
Authors: Guo Shuwei , Liu Youzhi , Zhang Chao , Zhang Chengqian , Wang Shufei , Li Yuliang , Cheng Shangyuan
Published: January 2024

High-gravity wet dust removal technology has attracted much attention because of its potential to cut liquid into smaller liquid droplets and lower energy consumption. However, the complex structure and the high-speed rotation of the rotating packed bed do not allow us to analyze the flow field using conventional methods, and thus the capture mechanism of fine particles in a high-gravity environment is poorly understood. In this study, a two-dimensional computational fluid dynamics model was established to investigate the distribution of the gas–liquid two-phase flow field inside of a rotating packed bed. The characteristics of the flow field, such as the liquid form, gas–liquid contact time, and gas flow path, were investigated, and the droplet size distribution and gas–liquid slip velocity were quantitatively analyzed. The inertial capture efficiency was calculated using the Stokes number, and the dust removal efficiency distribution in the rotating packed bed was compared. The reason for the high collection efficiency of fine particles by the high-gravity wet dust removal technology was explained by numerical simulations. Two new structures were designed to improve the total dust removal efficiency.
Geomagnetic and Cosmic Ray Activity Effect on Heart Rate during the Solar Cycle 24
Authors: Papailiou Maria-Christina , Ioannidou Sofia , Tezari Anastasia , Mavromichalaki Helen
Published: January 2024

The number of investigations relevant to the study of geomagnetic activity, solar events, and cosmic rays, i.e., space weather phenomena, and their impact on human health has increased dramatically over the past few years. Numerous studies examine the reaction of the cardiovascular, nervous, and other functional systems to variations observed in geospace. These studies examine the behavior of human physiological parameters not only during different levels of activity of the Sun and in the interplanetary space (from no activity to remarkably intense activity) but also through geomagnetic activity storms and Forbush decreases. Here, individuals from the Hippocratio General Hospital in Athens, the cardiology clinics of Nikaia General Hospital in Piraeus, and the Heraklion University Hospital in Crete, Greece, were assessed during the time period from 2011 until 2018. The heart rate of the individuals was recorded every hour via the Holter electrocardiogram method. Data were analyzed using the analysis of variance (ANOVA) and the method of superimposed epochs. The investigation covers not only the ascending but also the descending phase of the solar cycle 24 (lasting until 2019 and with its maximum in the year 2014).
The Return Period Wind Speed Prediction of Beijing Urban Area Based on Short-Term Measured Wind Speed
Authors: Chen Weihu , Tian Yuji
Published: January 2024

To predict and explore the return period wind speed distribution in Beijing urban area, based on the short-term measured wind speed record, the measured independent storm peak samples are extracted and the Monte–Carlo numerical simulation method is used to randomly generate pseudo-independent storm peak samples with the same distribution as the independent storm peak samples. In addition, the appropriate threshold is used to select and extract the over-threshold independent storm peak samples from the measured samples. And, then, the return period wind speed of the whole wind direction is predicted. Further, the traditional Cook method is used to predict and analyze the return period wind speed of each wind direction according to the measured wind speed data. The results show that the return period wind speed prediction results of the whole wind direction corresponding to the simulated pseudo samples and the measured over-threshold samples are basically close to each other, and the maximum relative deviation is less than 7%. The mean relative deviation of the return period wind speed prediction results is about 10.6% between each wind direction and the whole wind direction, and the mean relative deviation is about 9.4% between the RPWS prediction result of each wind direction and the design value of the code. In addition, the return period wind speed prediction values of the west by southwest, northwest and north by northeast wind directions exceed the design value of the code, while the predicted values of the other wind directions are within the envelope range of the design value of the code. Finally, the research content of this paper can provide some reference for the wind resistance design analysis of building structures in Beijing area.
Iridescence Mimicking in Fabrics: A Ultraviolet/Visible Spectroscopy Study
Authors: Fernandes Rui D. V. , Pranovich Alina , Valyukh Sergiy , Zille Andrea , Hallberg Tomas , Järrendahl Kenneth
Published: January 2024

Poly(styrene-methyl methacrylate-acrylic acid) photonic crystals (PCs), with five different sizes (170, 190, 210, 230 and 250 nm), were applied onto three plain fabrics, namely polyamide, polyester and cotton. The PC-coated fabrics were analyzed using scanning electronic microscopy and two UV/Vis reflectance spectrophotometric techniques (integrating sphere and scatterometry) to evaluate the PCs’ self-assembly along with the obtained spectral and colors characteristics. Results showed that surface roughness of the fabrics had a major influence on the color produced by PCs. Polyamide-coated fabrics were the only samples having an iridescent effect, producing more vivid and brilliant colors than polyester and cotton samples. It was observed that as the angle of incident light increases, a hypsochromic shift in the reflection peak occurs along with the formation of new reflection peaks. Furthermore, color behavior simulations were performed with an illuminant A light source on polyamide samples. The illuminant A simulation showed greener and yellower structural colors than those illuminated with D50. The polyester and cotton samples were analyzed using scatterometry to check for iridescence, which was unseen upon ocular inspection and then proven to be present in these samples. This work allowed a better comprehension of how structural colors and their iridescence are affected by the textile substrate morphology and fiber type.
Solution-Induced Degradation of the Silicon Nanobelt Field-Effect Transistor Biosensors
Authors: Lin Jung-Chih , Zhou Zhao-Yu , Cheng Yi-Ching , Chang I-Nan , Lin Chu-En , Wu Chi-Chang
Published: January 2024

Field-effect transistor (FET)-based biosensors are powerful analytical tools for detecting trace-specific biomolecules in diverse sample matrices, especially in the realms of pandemics and infectious diseases. The primary concern in applying these biosensors is their stability, a factor directly impacting the accuracy and reliability of sensing over extended durations. The risk of biosensor degradation is substantial, potentially jeopardizing the sensitivity and selectivity and leading to inaccurate readings, including the possibility of false positives or negatives. This paper delves into the documented degradation of silicon nanobelt FET (NBFET) biosensors induced by buffer solutions. The results highlight a positive correlation between immersion time and the threshold voltage of NBFET devices. Secondary ion mass spectrometry analysis demonstrates a gradual increase in sodium and potassium ion concentrations within the silicon as immersion days progress. This outcome is ascribed to the nanobelt’s exposure to the buffer solution during the biosensing period, enabling ion penetration from the buffer into the silicon. This study emphasizes the critical need to address buffer-solution-induced degradation to ensure the long-term stability and performance of FET-based biosensors in practical applications.
Velocity-Selective Arterial Spin Labeling Perfusion in Monitoring High Grade Gliomas Following Therapy: Clinical Feasibility at 1.5T and Comparison with Dynamic Susceptibility Contrast Perfusion
Authors: Lambrecht Sebastian , Liu Dapeng , Dzaye Omar , Kamson David O. , Reis Jonas , Liebig Thomas , Holdhoff Matthias , Van Zijl Peter , Qin Qin , Lin Doris D. M.
Published: January 2024

MR perfusion imaging is important in the clinical evaluation of primary brain tumors, particularly in differentiating between true progression and treatment-induced change. The utility of velocity-selective ASL (VSASL) compared to the more commonly utilized DSC perfusion technique was assessed in routine clinical surveillance MR exams of 28 patients with high-grade gliomas at 1.5T. Using RANO criteria, patients were assigned to two groups, one with detectable residual/recurrent tumor (“RT”, n = 9), and the other with no detectable residual/recurrent tumor (“NRT”, n = 19). An ROI was drawn to encompass the largest dimension of the lesion with measures normalized against normal gray matter to yield rCBF and tSNR from VSASL, as well as rCBF and leakage-corrected relative CBV (lc-rCBV) from DSC. VSASL (rCBF and tSNR) and DSC (rCBF and lc-rCBV) metrics were significantly higher in the RT group than the NRT group allowing adequate discrimination (p < 0.05, Mann–Whitney test). Lin’s concordance analyses showed moderate to excellent concordance between the two methods, with a stronger, moderate correlation between VSASL rCBF and DSC lc-rCBV (r = 0.57, p = 0.002; Pearson’s correlation). These results suggest that VSASL is clinically feasible at 1.5T and has the potential to offer a noninvasive alternative to DSC perfusion in monitoring high-grade gliomas following therapy.
Cognitive-Motor Training Improves Reading-Related Executive Functions: A Randomized Clinical Trial Study in Dyslexia
Authors: Ramezani Mehdi , Fawcett Angela J.
Published: January 2024

Children with developmental dyslexia (DD) often struggle with executive function difficulties which can continue into adulthood if not addressed. This double-blinded randomized clinical trial study evaluated the short-term effects of the Verbal Working Memory-Balance (VWM-B) program on reading-related executive functions, reading skills, and reading comprehension in Persian children with DD. The active control group [12 children with DD with a mean age of 9 years (SD = 0.90)] received training using the single-task VWM program, while the experiment group [15 children with DD with a mean age of 8 years (SD = 0.74)] received training with the dual-task VWM-B program. Both groups received fifteen training sessions, and assessments were conducted before and after the intervention. The groups were homogenized for possible confounders of age, gender, IQ level, and attention level. The study employed separate mixed ANOVA analyses to estimate the impact of training programs on various measured functions. Significant improvements were observed in the outcome measures of backward digit span, text comprehension, verbal fluency, Stroop color–word test and interference, and the reading subtests. Additionally, significant correlations were found between reading skills and backward digit span, text comprehension, verbal fluency, and Stroop variables. In conclusion, the dual-task VWM-B program was found to be more effective than the single-task VWM program in improving selective attention, cognitive inhibition, verbal working memory capacity, information processing speed, naming ability, and lexical access speed. These enhanced executive functions were associated with improved reading skills in children with DD.
The Urban–Rural Heterogeneous Effect of Family SES on Achievement: The Mediating Role of Culture
Authors: Wang Ningning
Published: January 2024

Previous studies have fully discussed the relationship between family socioeconomic status (SES) and achievement, but few of them regarded urban–rural differences as the moderating factor, which is an essential issue in urban–rural educational equalization in terms of educational outcomes. This study discusses the urban–rural heterogeneous effect of family SES on achievement and manifests the mediating role of education-related cultural factors. Based on the China Education Panel Survey data of 18,672 junior high school students, this study found the following: (1) family SES had a weaker positive effect among rural children than among urban children; (2) the urban–rural heterogeneous effect could be mediated by education-related cultural factors, i.e., learning environments and beliefs; and (3) in this regard, contemporary China is experiencing cultural reproduction rather than a cultural mobility mode. In Conclusion, although the urban–rural achievement gap will be maintained or even expanded in China, improving rural children’s learning environments and beliefs opens up the possibility of alleviating disadvantages in achievement resulting from family socioeconomic disadvantages. Therefore, narrowing down the urban–rural achievement gap from a cultural perspective provides policy implications for educational development in rural areas.
Navigating Adult Life from Emerging to Middle Adulthood: Patterns of Systemic Influences and Time Perspective in Migrants
Authors: Sgaramella Teresa Maria , Zammitti Andrea , Magnano Paola
Published: January 2024

This study emerges at the intersection of adult development and systems theory frameworks and their contributions to understanding migration experiences and associated cultural transitions. The adult development approach enables a deep understanding of the complexities that adults experience when they move from exploring themselves and their environment in emerging adulthood to establishing their identities and roles during middle adulthood. The systems theory framework, on the other hand, provides insights into the role of social and cultural dimensions in the lives of emerging and middle-adult immigrants who have navigated diverse cultures, roles, and identities. The study highlights the patterns and dynamic interactions of diverse systems of influences and their roles in shaping the self and relational identities of thirty emerging and middle-aged adults who have experienced migration.
Not All Levels of Social Re-Inclusion Allow for Recovery from Negative Outcomes of Social Exclusion: The Moderating Role of Self-Esteem
Authors: Kuang Beibei , Ng Sik Hung , Peng Shenli , Hu Ping , Wei Yanqiu
Published: January 2024

Previous studies on social exclusion have focused on its adverse effects, rarely exploring how social re-inclusion can aid recovery from exclusion-induced distress. The level of social re-inclusion that can help individuals recover from social exclusion, and whether the recovery effect is influenced by individual characteristics are unclear. The present experimental study extends the Cyberball paradigm, adding a re-inclusion stage to explore the recovery effects of four levels of social re-inclusion on affect; furthermore, it tests the moderating role of self-esteem in the recovery effect. A total of 154 Chinese college students participated in the experiment. Results showed that (1) recovery was effective when the level of re-inclusion was equal to (replica re-inclusion) or greater than (moderate and high over-re-inclusions) the pre-exclusion level of inclusion, but ineffective when it was below this level (token re-inclusion); (2) the re-inclusion level positively predicted recovery, and this was moderated by self-esteem—the prediction was effective for participants with middle and high self-esteem, but not for participants with low self-esteem. These results are discussed from a group process and self-psychology perspective.
Evaluation of Residential Buildings Savings for Various Envelope Retrofits and Heating Energy Sources: A Simulation Study
Authors: Ponechal Radoslav , Jandačka Jozef , Ďurica Pavol
Published: January 2024

The paper considers the issue of the thermal refurbishment of residential buildings built between 10 and 40 years ago in some European countries. It suggests that, while facade retrofitting is the most effective solution for older dwellings, all actions are equally less effective for newer dwellings built in this millennium. According to the current situation, as society shifts away from the use of fossil fuels, this paper presents the expected energy and financial savings that were calculated using one of four different heating sources. The study shows that the efficiency of the additional thermal retrofitting of the structures is low when the building is heated with a heat pump. The addition of thermal insulation to already well-insulated roofs or floors results in minimal savings of approximately 0.15 kWh per square meter of heated floor area per year. The potential advantage of replacing existing windows with new windows in a top thermal quality was shown. After window replacement, the financial benefits could be twice as high in houses heated by district heating compared to houses heated by gas or a heat pump, including an alternative heat pump with photovoltaics.
Assessing the Delay, Cost, and Quality Risks of Claims on Construction Contract Performance
Authors: Antoniou Fani , Tsioulpa Alexandra Vassiliki
Published: January 2024

Conflicts are frequent within the complex professional environment of the construction industry. If claims cannot be overcome amicably, they result in disputes that lead to litigation. Identification of the causes of these claims and their impact on the duration, cost, and quality of the final project is expected to facilitate the prevention of unsuccessful performance of construction contracts. The novelty of this study is that after codifying the most common causes of construction contract claims derived from the extant literature, they are further investigated in terms of their probability of occurrence and the perceived impact they have on the project completion time, its total cost, and quality. Based on calculated relative importance indices from expert opinion, this paper proposes probability and severity of impact values for 39 common causes of claims in the construction industry. These can be applied to calculate their risk values for stakeholders in public construction contracts to plan mitigation measures for contractual claims. The findings show that the top five highest risk causes of contractual claims in the Greek construction industry are changes in quantities, work, or scope, design quality deficiencies or errors, payment delays, delays in work progress, and the financial failure of the contractor.
Reporting on the Development of a Web-Based Prototype Dashboard for Construction Design Managers, Achieved through Design Science Research Methodology (DSRM)
Authors: Gledson Barry , Rogage Kay , Thompson Anna , Ponton Hazel
Published: January 2024

Construction Design Management (DM) involves the coordination of design processes and activities to ensure quality project design, yet it involves many challenges. This study reports on a collaborative Knowledge Transfer Partnership (KTP) project with a Case Study Organization (CSO) that tackled several issues faced by construction design managers. Employing a design science research methodology (DSRM), qualitative analysis of semi-structured interviews with purposefully identified design managers uncovered real-world concerns around design co-ordination and performance monitoring. To address these concerns, a web-based design management prototype dashboard was developed using typical project data to aid in the management of design coordination, task prioritization, and reporting functionalities. The web-based Design Management prototype dashboard enhances design management productivity in construction firms by monitoring design production, assessing designer performance trends, and focusing on Technical Queries (TQs) and Requests for Information (RFIs). Digitalizing selected design management processes improves efficiency and productivity. The visual reporting of the dashboard enables design production monitoring at project and portfolio levels, assesses trends in designer performance, and maintains focus on TQs and RFIs. Demonstrating how web-based Design Management dashboards can enhance productivity, this study emphasizes practical solutions derived from employing a design science research methodology. The development and application of the web-based dashboard contribute to the growing evidence that employing design science research methodology in construction can yield tangible solutions to address real-world construction concerns.
Critical Review on the Energy Retrofitting Trends in Residential Buildings of Arab Mashreq and Maghreb Countries
Authors: Almomani Ahmad , Almeida Ricardo M. S. F. , Vicente Romeu , Barreira Eva
Published: January 2024

In the 21st century, global energy security is a critical concern. Buildings contribute to over 40% of the worldwide energy consumption, primarily due to heating and cooling, resulting in a third of greenhouse gas emissions. The residential sector accounts for 25% of global electricity consumption, and in the Arab Mashreq and Maghreb (AMM) countries, the residential sector consumes around 41% of the total electricity. Existing residential buildings constitute a significant portion of the building sector, playing a crucial role in the overall performance of the building sector. To address this issue, it is essential to invest in the energy retrofitting of existing unsustainable residential buildings. This study aims to provide a comprehensive critical review of the literature on residential buildings’ energy retrofitting trends in the AMM countries. Using a keyword-based search, 41 relevant studies were identified and critically analysed to identify gaps in the literature, benchmarking against global retrofit studies’ trends, including the absence of top-down and bottom-up physical approaches and the limited use of modern tools like BIM. Additionally, there is a significant lack of studies that present measured and verified case studies of implemented energy retrofitting projects. The study concludes with recommendations for future research to bridge the gaps in the literature.
Advancing Efficiency in Mineral Construction Materials Recycling: A Comprehensive Approach Integrating Machine Learning and X-ray Diffraction Analysis
Authors: Wilhelm Markus , Lotter Frank , Scherdel Christian , Schmitt Jan
Published: January 2024

In the context of environmental protection, the construction industry plays a key role with significant CO2 emissions from mineral-based construction materials. Recycling these materials is crucial, but the presence of hazardous substances, i.e., in older building materials, complicates this effort. To be able to legally introduce substances into a circular economy, reliable predictions within minimal possible time are necessary. This work introduces a machine learning approach for detecting trace quantities (≥0.06 wt%) of minerals, exemplified by siderite in calcium carbonate mixtures. The model, trained on 1680 X-ray powder diffraction datasets, provides dependable and fast predictions, eliminating the need for specialized expertise. While limitations exist in transferability to other mineral traces, the approach offers automation without expertise and a potential for real-world applications with minimal prediction time.
Combining Classic and Novel Neutrophil-Related Biomarkers to Identify Non-Small-Cell Lung Cancer
Authors: Ren Yunzhao , Wang Qinchuan , Xu Chenyang , Guo Qian , Dai Ruoqi , Xu Xiaohang , Zhang Yuhao , Wu Ming , Wu Xifeng , Tu Huakang
Published: January 2024

Background: Recent studies have revealed that neutrophils play a crucial role in cancer progression. This study aimed to explore the diagnostic value of neutrophil-related biomarkers for non-small-cell lung cancer (NSCLC). Methods: We initially assessed the associations between classic neutrophil-related biomarkers (neutrophil-to-lymphocyte ratio (NLR), absolute neutrophil counts (NEU), absolute lymphocyte counts (LYM)) and NSCLC in 3942 cases and 6791 controls. Then, we measured 11 novel neutrophil-related biomarkers via Luminex Assays in 132 cases and 66 controls, individually matching on sex and age (±5 years), and evaluated their associations with NSCLC risk. We also developed the predictive models by sequentially adding variables of interest and assessed model improvement. Results: Interleukin-6 (IL-6) (odds ratio (OR) = 10.687, 95% confidence interval (CI): 3.875, 29.473) and Interleukin 1 Receptor Antagonist (IL-1RA) (OR = 8.113, 95% CI: 3.182, 20.689) shows strong associations with NSCLC risk after adjusting for body mass index, smoking status, NLR, and carcinoembryonic antigen. Adding the two identified biomarkers to the predictive model significantly elevated the model performance from an area under the receiver operating characteristic curve of 0.716 to 0.851 with a net reclassification improvement of 97.73%. Conclusions: IL-6 and IL-1RA were recognized as independent risk factors for NSCLC, improving the predictive performance of the model in identifying disease.
Targeting NPC1 in Renal Cell Carcinoma
Authors: Fazliyeva Rushaniya , Makhov Peter , Uzzo Robert G. , Kolenko Vladimir M.
Published: January 2024

Rapidly proliferating cancer cells have a greater requirement for cholesterol than normal cells. Tumor cells are largely dependent on exogenous lipids given that their growth requirements are not fully met by endogenous pathways. Our current study shows that ccRCC cells have redundant mechanisms of cholesterol acquisition. We demonstrate that all major lipoproteins (i.e., LDL, HDL, and VLDL) have a comparable ability to support the growth of ccRCC cells and are equally effective in counteracting the antitumor activities of TKIs. The intracellular trafficking of exogenous lipoprotein-derived cholesterol appears to be distinct from the movement of endogenously synthesized cholesterol. De novo synthetized cholesterol is transported from the endoplasmic reticulum directly to the plasma membrane and to the acyl-CoA: cholesterol acyltransferase, whereas lipoprotein-derived cholesterol is distributed through the NPC1-dependent endosomal trafficking system. Expression of NPC1 is increased in ccRCC at mRNA and protein levels, and high expression of NPC1 is associated with poor prognosis. Our current findings show that ccRCC cells are particularly sensitive to the inhibition of endolysosomal cholesterol export and underline the therapeutic potential of targeting NPC1 in ccRCC.
Treatment Patterns and Health Outcomes among Patients with HER2 IHC0/-Low Metastatic or Recurrent Breast Cancer
Authors: Farah Eliya , Carbonell Chantelle , Boyne Devon J. , Brenner Darren R. , Henning Jan-Willem , Moldaver Daniel , Shokar Simran , Cheung Winson Y.
Published: January 2024

Improved understanding of the biological heterogeneity of breast cancer (BC) has facilitated the development of more effective and personalized approaches to treatment. This study describes real-world evidence on treatment patterns and outcomes for a population-based cohort of patients with human epidermal growth factor receptor (HER2) IHC0 and -low BC with de novo or recurrent disease from Alberta, Canada. Patients 18+ years old diagnosed with HER2 IHC0/-low, de novo/recurrent BC from 2010 to 2019 were identified using Alberta’s cancer registry. Analyses of these patients’ existing electronic medical records and administrative claims data were conducted to examine patient characteristics, treatment patterns, and survival outcomes. A total of 3413 patients were included in the study, of which 72.10% initiated first line hormonal and non-hormonal systemic therapy. The 1-year overall survival (OS) was 81.09% [95% CI, 79.52–82.69]. Recurrent patients had a higher OS compared to de novo patients: 54.30 months [95% CI, 47.80–61.90] vs. 31.5 months [95% CI, 28.40–35.90], respectively. Median OS was 43.4 months [95% CI, 40.70–47.10] and 35.80 months [95% CI, 29.00–41.70] among patients with HER2-low and HER2 IHC0 cancer, respectively. The study results provide real-world evidence regarding the clinical outcomes of HER2 IHC0/-low and de novo/recurrent disease.
Long-Term Functional Outcomes Following Surgical Treatment of Spinal Schwannomas: A Population-Based Cohort Study
Authors: Singh Aman , Fletcher-Sandersjöö Alexander , El-Hajj Victor Gabriel , Burström Gustav , Edström Erik , Elmi-Terander Adrian
Published: January 2024

Spinal schwannomas are the second most common form of primary intradural spinal tumor. Despite being benign, they may cause spinal cord compression and subsequently acute or chronic neurological dysfunction. The primary treatment is surgical resection. The aim of this study was to identify pre- and postoperative predictors of favorable outcomes after surgical treatment for spinal schwannoma. All adult patients surgically treated for spinal schwannoma between 2006 and 2020 were eligible for inclusion. Medical records and imaging data were retrospectively reviewed. The primary outcome measures were neurological improvement according to the modified McCormick Scale (mMC) and changes in motor deficit, sensory deficit, gait disturbance, bladder dysfunction, and pain at long-term follow-up. In total, 180 patients with a median follow-up time of 4.4 years were included. Pain was the most common presenting symptom (87%). The median time between symptom presentation and surgery was 12 months, while the median time between diagnosis (first MRI) and surgery was 3 months. Gross total resection (GTR) was achieved in 150 (83%) patients and the nerve root could be preserved in 133 (74%) patients. A postoperative complication occurred in 10 patients (5.6%). There were significant postoperative improvements in terms of motor, sensory, gait, and bladder functions, as well as pain (p < 0.001). Of these symptoms, bladder dysfunction was the one most often improved, with complete symptom resolution in all cases. However, no other predictors of improvement could be identified. There were three cases of recurrence after GTR and nine cases of regrowth after STR. Reoperation was performed in six (3.3%) cases. GTR was associated with a significant improvement in neurological status at long-term follow-up and increased the chance of progression-free survival.
Obesity and Cancer Rehabilitation for Functional Recovery and Quality of Life in Breast Cancer Survivors: A Comprehensive Review
Authors: Lippi Lorenzo , de Sire Alessandro , Folli Arianna , Turco Alessio , Moalli Stefano , Marcasciano Marco , Ammendolia Antonio , Invernizzi Marco
Published: January 2024

Obesity is a global health challenge with increasing prevalence, and its intricate relationship with cancer has become a critical concern in cancer care. As a result, understanding the multifactorial connections between obesity and breast cancer is imperative for risk stratification, tailored screening, and rehabilitation treatment planning to address long-term survivorship issues. The review follows the SANRA quality criteria and includes an extensive literature search conducted in PubMed/Medline, Web of Science, and Scopus. The biological basis linking obesity and cancer involves complex interactions in adipose tissue and the tumor microenvironment. Various mechanisms, such as hormonal alterations, chronic inflammation, immune system modulation, and mitochondrial dysfunction, contribute to cancer development. The review underlines the importance of comprehensive oncologic rehabilitation, including physical, psychological, and nutritional aspects. Cancer rehabilitation plays a crucial role in managing obesity-related symptoms, offering interventions for physical impairments, pain management, and lymphatic disorders, and improving both physical and psychological well-being. Personalized and technology-driven approaches hold promise for optimizing rehabilitation effectiveness and improving long-term outcomes for obese cancer patients. The comprehensive insights provided in this review contribute to the evolving landscape of cancer care, emphasizing the importance of tailored rehabilitation in optimizing the well-being of obese cancer patients.
The Effect of Precursor Concentration on the Crystallite Size of CeO2 to Enhance the Sulfur Resistance of Pt/CeO2 for Water Gas Shift
Authors: Hong Ga-Ram , Kim Kyoung-Jin , Ahn Seon-Yong , Kim Beom-Jun , Shin Bong-Gyeong , Oh Min-Ju , Lee Yeol-Lim , Roh Hyun-Seog
Published: January 2024

To develop customized sulfur–resistant catalysts for the water gas shift (WGS) reaction in the waste–to–hydrogen process, the effects of changing the nucleation conditions of the CeO2 support on catalytic performance were investigated. Supersaturation is a critical kinetic parameter for nuclei formation. The degree of supersaturation of the CeO2 precipitation solution was controlled by varying the cerium precursor concentration from 0.02 to 0.20 M. Next, 2 wt.% of Pt was impregnated on those various CeO2 supports by the incipient wetness impregnation method. The prepared samples were then evaluated in a WGS reaction using waste–derived synthesis gas containing 500 ppm H2S. The Pt catalyst supported by CeO2 prepared at the highest precursor concentration of 0.20 M exhibited the best sulfur resistance and catalytic activity regeneration. The sulfur tolerance of the catalyst demonstrated a close correlation with its oxygen storage capacity and easier reducibility. The formation of oxygen vacancies in CeO2 supports is promoted by the formation of small crystals due to a high degree of supersaturation.
Gas-Phase Oxidative Dehydrogenation of n-Octane over Metal Oxide Catalysts: A Review
Authors: Ntola Pinkie , Shozi Mzamo
Published: January 2024

The oxidative dehydrogenation (ODH) of alkanes, whereby hydrogen is removed to form unsaturated compounds, is an important process, particularly in the petrochemical industry. The ODH of lighter alkanes (C3–C6) is well-reported in the literature, and while there are several reports on the ODH of n-octane (C8), there is no reported review of the important findings in the literature. This review discusses the gas-phase ODH of n-octane occurring at high temperatures (300–550 °C). The mechanisms via which the n-octane ODH of occurs are also briefly discussed. The oxidants (mainly O2 and CO2) and catalysts (supported and unsupported metal oxides) are discussed as well as the effect of these and the temperature on the type of products formed and their various distributions. Furthermore, the review looks at the acid–base and redox properties of the catalysts and how they affect product formation. Some challenges as well as perspectives of the ODH process are also highlighted.
Unravelling the Influence of Binder Typology during the Additive Manufacturing of Hybrid Multi-Channel Cylinders for Catalytic Purposes
Authors: Todaro Serena , Bonura Giuseppe , Cajumi Alessandro , Santoro Mariarita , Randazzo Fabrizio , Giacoppo Giosuè , Frusteri Francesco , Cannilla Catia
Published: January 2024

In this work, a 3D printing methodology based on the robocasting of catalytic ink pastes was applied to obtain structured matrix-like cylinders as innovative materials for an effective utilization of carbon dioxide. The influence of three different binders (i.e., PEI, HPMC and MC) on the physio-chemical, mechanical and catalytic properties of multi-channel monoliths was studied against a reference binder-free powdered system in order to envisage the effectiveness of the printing procedure in realizing hybrid advanced materials at a higher control and reproducibility than from traditional preparation techniques. In terms of textural and structural properties, the micro-extruded 3D cylinders only evidenced a slight difference in terms of relative crystallinity, with minor effects on the surface area exposure in relation to the specific binder used during the direct ink writing process. More importantly, the typology of binder significantly affected the rheological properties of the catalytic ink, with the need of a controlled viscosity to ensure a suitable thixotropic behaviour of the extrudable pastes, finally determining an optimal mechanical resistance of the final 3D monolith. The experimental validation of the hybrid multi-channel cylinders under conditions of CO2 hydrogenation demonstrated the great potential of additive manufacturing in the realization of catalyst architectures characterized by unique features and fidelity scarcely reproducible via conventional synthetic techniques.
Innovative Catalytic Materials for Environmental Remediation and Energy Applications
Authors: Bampos Georgios , Petala Athanasia , Frontistis Zacharias
Published: January 2024

The need for low-cost and environmentally friendly energy is greater than ever nowadays due to the global population growth as well as the modern lifestyle [...]
Putative Roles and Therapeutic Potential of the Chaperone System in Amyotrophic Lateral Sclerosis and Multiple Sclerosis
Authors: Noori Leila , Saqagandomabadi Vahid , Di Felice Valentina , David Sabrina , Caruso Bavisotto Celeste , Bucchieri Fabio , Cappello Francesco , Conway de Macario Everly , Macario Alberto J. L. , Scalia Federica
Published: January 2024

The putative pathogenic roles and therapeutic potential of the chaperone system (CS) in amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are reviewed to provide a bibliographic and conceptual platform for launching research on the diagnostic and therapeutic applications of CS components. Various studies suggest that dysfunction of the CS contributes to the pathogenesis of ALS and MS, and here, we identify some of the implicated CS members. The physiology and pathophysiology of the CS members can be properly understood if they are studied or experimentally or clinically manipulated for diagnostic or therapeutic purposes, bearing in mind that they belong to a physiological system with multiple interacting and dynamic components, widespread throughout the body, intra- and extracellularly. Molecular chaperones, some called heat shock protein (Hsp), are the chief components of the CS, whose canonical functions are cytoprotective. However, abnormal chaperones can be etiopathogenic factors in a wide range of disorders, chaperonopathies, including ALS and MS, according to the data reviewed. Chaperones typically form teams, and these build functional networks to maintain protein homeostasis, the canonical role of the CS. However, members of the CS also display non-canonical functions unrelated to protein homeostasis. Therefore, chaperones and other members of the CS, if abnormal, may disturb not only protein synthesis, maturation, and migration but also other physiological processes. Thus, in elucidating the role of CS components in ALS and MS, one must look at protein homeostasis abnormalities and beyond, following the clues emerging from the works discussed here.
EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor
Authors: Sprinzen Lisa , Garcia Franklin , Mela Angeliki , Lei Liang , Upadhyayula Pavan , Mahajan Aayushi , Humala Nelson , Manier Lisa , Caprioli Richard , Quiñones-Hinojosa Alfredo , Casaccia Patrizia , Canoll Peter
Published: January 2024

Isocitrate Dehydrogenase-1 (IDH1) is commonly mutated in lower-grade diffuse gliomas. The IDH1R132H mutation is an important diagnostic tool for tumor diagnosis and prognosis; however, its role in glioma development, and its impact on response to therapy, is not fully understood. We developed a murine model of proneural IDH1R132H-mutated glioma that shows elevated production of 2-hydroxyglutarate (2-HG) and increased trimethylation of lysine residue K27 on histone H3 (H3K27me3) compared to IDH1 wild-type tumors. We found that using Tazemetostat to inhibit the methyltransferase for H3K27, Enhancer of Zeste 2 (EZH2), reduced H3K27me3 levels and increased acetylation on H3K27. We also found that, although the histone deacetylase inhibitor (HDACi) Panobinostat was less cytotoxic in IDH1R132H-mutated cells (either isolated from murine glioma or oligodendrocyte progenitor cells infected in vitro with a retrovirus expressing IDH1R132H) compared to IDH1-wild-type cells, combination treatment with Tazemetostat is synergistic in both mutant and wild-type models. These findings indicate a novel therapeutic strategy for IDH1-mutated gliomas that targets the specific epigenetic alteration in these tumors.
Beyond Allergies—Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis
Authors: Lerner Liron , Babina Magda , Zuberbier Torsten , Stevanovic Katarina
Published: January 2024

Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic diseases, where recent data show that non-IgE-mediated activation is also of relevance, especially in chronic urticaria (CU) and atopic dermatitis (AD). Skin MCs express Mas-related G-protein-coupled receptor X2 (MRGPRX2), a key protein in non-IgE-dependent MC degranulation, and its overactivity is one of the triggering factors for the above-mentioned diseases, making MRGPRX2 a potential therapeutic target. Reviewing the latest literature revealed our need to focus on the discovery of MRGPRX2 activators as well as the ongoing vast research towards finding specific MRGPRX2 inhibitors for potential therapeutic approaches. Most of these studies are in their preliminary stages, with one drug currently being investigated in a clinical trial. Future studies and improved model systems are needed to verify whether any of these inhibitors may have the potential to be the next therapeutic treatment for CU, AD, and other pseudo-allergic reactions.