bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of a short-term multi-modal prehabilitation intervention on the systemic stress response in patients undergoing semi-elective surgery for gastrointestinal cancer: a randomized controlled clinical trial
Authors: Fang Fang , Tai Rui , Han Chao , Huang Chen , Zhang Yaqing
Published: November 2023

Objective
To evaluate the possible effects of short-term multi-modal prehabilitation intervention on the post-operative stress response in patients undergoing semi-elective surgery for gastrointestinal cancer.
Methods
A prospective and randomized clinical study was conducted in 84 patients with gastrointestinal cancers who underwent semi-elective surgery in a single university clinical hospital from June 2023 to October 2023. Patients were randomized into the standard (SD) group and the short-term prehabilitation (STP)group (1:1). The SD group received routine treatment and care, while the STP group received one-week prehabilitation including physical exercise, nutritional, and psychosocial interventions. Changes in post-operative stress response, outcome and recovery of patients in each group were observed.
Results
The two groups of patients were similar in terms of age, gender, body mass index, ASA grade and tumor type. After surgery, concentrations of epinephrine(6h), C-reactive protein(7d), and IL-6(6h) levels were significantly lower in the STP group than in the SD group(P < 0.05). There were no significant differences in patients postoperative norepinephrine, insulin, glucose, IL-8 expression levels between the two groups at all time points. Besides, the time to first flatus(P = 0.02), first diet(P = 0.01) and ambulation(P = 0.01) were significantly reduced in the STP group than those in the SD group. Differences in drainage removal time, postoperative hospital stay, postoperative complications were not statistically significant.
Conclusion
Our findings demonstrated that levels of certain metabolic(epinephrine), acute phase(CRP) and cytokine(IL-6) parameters were significantly lower in the STP group than in the SD group, which reflected a lesser degree of postoperative stress response in gastrointestinal cancer patients associated with the short-term prehabilitation. Furthermore, patients gastrointestinal function and exercise tolerance could recover more quickly.
Registration number
This randomized, and controlled clinical trial was approved by the ethics committee of our hospital and registered in Chinese Clinical Trial Registry in January 2022 with the registration number ChiCTR2200055764.
Another market segment: Sport Event Tourism (SET) by Disabled Athletes (DA)
Authors: Yun Seokmin , Kim Kyungjin , Lee Sangyung , Kim Young Hoon
Published: November 2023

Sports and tourism are connected in various parts of economies, cultures, and nations. However, there has been a limited understanding of sports event tourism involving disabled athletes. This study explored the behavioral and socio-demographic implications of the disabled sports event tourism and investigated the motivational factors Involved. An in-person survey was administered to 108 disabled athletes who attended the summer and winter Paralympics. The results showed that life satisfaction had a significant direct effect on future intentions. Emotional happiness had a significant direct effect on the perceived value of an event. Escapism had significant direct effects on perceived value and future intentions. Perceived value significantly influenced future intentions. The relationship between emotional happiness and future intention was fully mediated by perceived value. However, the relationship between escapism and future intention was only partially mediated by perceived value. The results of this study are valuable for developing future management and marketing policies for disabled athletes and tourists.
Carrot Pomace Powder: A Promising Source of Polyphenols and Prebiotics for Improving Gut Health
Authors: Mall Urvashi P. , Patel V. H.
Published: November 2023

Purpose: This study aimed to evaluate the properties of carrot pomace, including its nutritional composition, physiochemical attributes, change in polyphenols, and prebiotic potential during in vitro gastrointestinal digestion and fermentation.
Methods:The study involved evaluating the nutritional and physiochemical properties of carrot pomace. It also assessed an in vitro gastrointestinal digestion model to evaluate changes in polyphenol levels and antioxidant properties at different digestive stages. The study also examined the prebiotic potential by analysing the growth of Lactobacillus acidophilus and short-chain fatty acid production by in vitro fermentation assay. High-resolution LC-MS analysis was used to identify polyphenolic compounds before and after digestion.
Results: The findings demonstrated that carrot pomace powder contained 43.59% dietary fiber. During in vitro digestion, polyphenols content and antioxidant properties (TPC, TFC, FRAP, DPPH-RSA, and ABTS-RSA) were significantly different at each digestive stage, with strong correlations observed among polyphenols and antioxidant. Notably, polyphenol recovery percentages were significant throughout the digestion phases. Carrot pomace also exhibited prebiotic properties by promoting the growth of L. acidophilus and enhancing short-chain fatty acid production. High-resolution LC-MS analysis revealed eight polyphenolic compounds and their metabolites found in carrot pomace powder (CPP) before and three polyphenolic compounds present after in vitro gastrointestinal digestion.
Conclusion:This research indicated that polyphenols from carrot pomace could potentially play a role in gastrointestinal and colonic health. The utilization of valuable bio-resources as carrot by-products is another step forward in waste management and reducing the primary waste generated by the industry.
Development of Warp Knitted-Based Filtration Media
Authors: Lenfeldová Irena , Ryvolová Martina , Kdýrová Adéla
Published: November 2023

Biological wastewater treatment based on the removal of various nitrogen forms using activated sludge is a highly efficient and economical method with environmental benefits. The activated sludge comprises bacteria that form colonies on solid carriers (e.g., the most commonly used carrier, AnoxKaldnes). The initial concept behind designing a warp knitted fabric structure (i.e., spacer fabric) with holes is based on the appearance similarity of a three-dimensional fabric and a solid carrier, focusing on potential industrial production. In this study, the longitudinal textile properties of multi- and monofilament materials are measured. A structural analysis is conducted to produce samples unraveled and separated by mono and multifilaments. Density, weight, loop length, filament consumption, specific surface area, and effective area are calculated. Through a basic experiment in a laboratory nitrification reactor, a biofilm is formed on the carriers. The analysis results of the O2 consumption rate of individual design variants reveals minimal differences after 6 and 14 weeks. The efficient carrier area on the outer and inner front and back sides of four developed carrier variants is measured after cutting the monofilaments with the image analysis support. This study might be helpful in designing other textile-based carriers. The warp knitted carrier presented herein demonstrates the capture and presence of an active biofilm evidenced by a higher oxygen consumption rate of up to 8 mg/L/h in 6 weeks. It also shows the benefit of commercially available warp knitted carrier manufacturing.
Palynomorphological study of Azerbaijanian Rubus species in comparison with the morphology of pollen of the whole genus
Authors: Asilbeyova Terlan , Gavrilova Olga , Krasovskaya Liudmila , Pozhidaev Andrey
Published: November 2023

We investigated pollen morphology of Rubus species from Azerbaijan. Pollen of 24 specimens from 15 species of all three Rubus subgenera has been studied using light, confocal laser scanning and scanning electron microscopes to estimate pollen characteristic variability and to describe pollen polymorphism and taxonomic value. Pollen grains are small or medium-sized, mainly three-colporate and spheroidal; composed apertures include meridional directed, long, narrow colpi and clear ori on the equator. Exine is thin, tectate and columellate, ornamentation is striate or striate-perforate with thin mainly long striae and perporations from zero to numerous between striae. Pollen of Azeri Rubus species are similar to European ones and it is difficult to distinguish from each other. Intraspecific and individual variability is manifested in size, shape, number and location of apertures, and patterns of ornamentation. The ordered structure of the individual variability of the characteristic shape (number and location of apertures) of pollen grains in the genus Rubus is described. An abundance of deviant forms was noted in the subgenus Rubus. An analysis of pollen morphology of investigated Rubus taxa around the world demonstrated that diagnostic feature into genus is ornamentation which can be divided into three groups: typical striate; non-typical striate and non-striate. The subgenus Rubus is uniform in exine pattern. Typical striate pollen is found throughout the world; however, variations of non-typical striate and non-striate pollen is revealed in Southeast Asia. Pollen data indicate a geographical center of species diversity in Southeast Asia.
Machine Learning Analysis of Gene Expression Reveals TP53 Mutant-like AML With Wild Type TP53 And Poor Prognosis
Authors: Sachs Zohar , Lee Yoonkyu , Baughn Linda , Myers Chad
Published: November 2023

Acute myeloid leukemia (AML) with TP53 mutations (TP53Mut) has poor clinical outcomes. We investigated whether this AML subtype harbors a distinct gene expression profile (GEP) and whether this GEP is prognostic in TP53 wild type (TP53WT) AML.
We applied a supervised machine-learning approach to detect the TP53Mut GEP. We divided the samples in the Beat-AML dataset into training and testing datasets. The TCGA LAML dataset was used as a validation dataset. We trained a ridge regression machine learning model to classify TP53Mut and TP53WT cases. This model was highly accurate in distinguishing TP53Mut versus TP53WT cases in both the test and validation datasets. Additionally, we identified TP53WT samples with high ridge regression scores. These high-scoring TP53WT samples also have poor overall survival, suggesting they share clinical and GEP features with TP53Mut AML. We defined these TP53WT samples as TP53Mut-like. Using drug sensitivity data in the Beat AML dataset, we found TP53Mut-like AMLs have distinct drug sensitivity patterns that phenocopy TP53Mut cases. Finally, we identified a 25-gene signature that can identify TP53Mut-like AML. This signature could be used clinically to identify this novel subset of poor-prognosis AML.
Adverse Event Management in Patients with Platinum-Resistant Ovarian Cancer Treated with Niraparib and Anlotinib: Updates from the Phase II, Multi-Center ANNIE Study
Authors: Deng Ting , Yan Lei , Li Jing , Liu Guochen , Yin Aijun , Feng Yanling , Zheng Min , Zhang Chuyao , Huang He , Huang Qidan , Lin An , Jiang Jie , Kong Beihua , Liu Jihong
Published: November 2023

Background: The primary analysis of the ANNIE study demonstrated promising anti-tumor activity of the niraparib-anlotinib combination in platinum-resistant recurrent ovarian cancer (PROC). We report updated overall survival (OS) and safety data and the management of key treatment-emergent adverse event (TEAE) from the ANNIE study.
Methods: In the multi-center, single-arm, phase 2 ANNIE study, enrolled patients received oral niraparib 200 mg or 300 mg (baseline bodyweight-directed) once daily and anlotinib 10 mg (12 mg before protocol amendment) once daily on days 1–14 of each 21-day cycle. Safety management involved a multidisciplinary team comprising specialist physicians, who performed monitoring and intervention for key comorbidities and TEAEs.
Results: Forty patients were enrolled. After a median follow-up of 19.0 months, the updated median OS was 18.2 months (95% confidence interval: 12.1–not evaluable). The most common TEAEs were hypertension (n=22, 55%), leukopenia (n=18, 45%), hand-foot syndrome (n=17, 43%), thrombocytopenia (n=15, 38%), neutropenia (n=14, 35%), and hypertriglyceridemia (n=12, 30%). Hypertension and cardiovascular events were mostly managed by early interventions using beta-blockers. Hypertriglyceridemia was mostly managed using atorvastatin and simvastatin. Hematological toxicities were consistent with prior studies and no severe hematologic events occurred. Protocol amendment was implemented to reduce the incidence of hand-foot syndrome, while topical glucocorticoids and non-steroidal anti-inflammatory drugs were used in patients with apparent symptoms.
Conclusions: The updated OS analysis showed sustained long-term efficacy of niraparib-anlotinib in PROC patients. The safety data reflected satisfactory tolerability and adverse event management, supporting the involvement of a multidisciplinary disease management team in ovarian cancer care.
Clinical trial registration: NCT04376073
Functional Inorganics Driven by Immiscibility
Authors: Li Yizhe
Published: November 2023

The authors have requested that this preprint be removed from Research Square.
The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis
Authors: Naval-Baudin Pablo , Pons-Escoda Albert , Castillo-Pinar Albert , Martínez-Zalacaín Ignacio , Arroyo-Pereiro Pablo , Flores-Casaperalta Susanie , Garay-Buitron Francis , Calvo Nahum , Martínez-Yélamos Antonio , Cos Mònica , Martínez-Yélamos Sergio , Majós Carles
Published: November 2023

Objectives:
Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic biomarker of disability progression in multiple sclerosis (MS). However, SWI is not always available in clinical practice. The objective of this study is to define a novel imaging sign, the T1-dark rim, identifiable in a standard 3DT1 gradient-echo sequence, such as 3D T1 turbo field echo (3DT1FE) and explore its performance as a SWI surrogate to define PRLs.
Materials & Methods:
This observational cross-sectional study analyzed MS patients who underwent 3T magnetic resonance imaging (MRI) including 3DT1TFE and SWI. Rim lesions were evaluated in 3DT1TFE, processed SWI, and SWI phase and categorized as true positive, false positive, or false negative based on the value of the T1-dark rim in predicting SWI phase PRLs. Sensitivity and positive predictive values of the T1-dark rim for detecting PRLs were calculated.
Results:
Overall, 80 rim lesions were identified in 63 patients (60 in the SWI phase and 78 in 3DT1TFE; 58 true positives, 20 false positives, and two false negatives). The T1-dark rim demonstrated 97% sensitivity and 74% PPV for detecting PRLs. More PRLs were detected in the SWI phase than in processed SWI (60 and 57, respectively).
Conclusion:
The T1-dark rim sign is a promising and accessible novel imaging marker to detect PRLs whose high sensitivity may enable earlier detection of smoldering inflammation to guide MS treatment escalation. The relevance of T1-dark rim lesions that are negative on SWI opens up a new field for analysis.
Unravelling the Three-Dimensional Structure-Function Relationships of Interstitial Cells of Cajal Networks: A Graph Theoretical Approach to Neurogastroenterology
Authors: Mah Sue Ann , Avci Recep , Vanderwinden Jean-Marie , Du Peng
Published: November 2023

Specific structural traits such as deficient or altered networks of interstitical cells of Cajal (ICC) are often observed in gastroparesis, constipation, chronic intestinal pseudo-obstruction, and Hirschsprung disease based on qualitative histopathological findings, serve as key factors in inferring the health of gastrointestinal (GI) motility function. However, the assessment of ICC at present is limited by the lack of readily available 3D quantitative metrics. Although confocal microscopy can image and quantify the spatial distribution of ICC networks, current techniques to evaluate ICC in histological studies are limited to nuclei counts, or simply by objective visual grading. Although a suite of numerical metrics for the quantitative assessment of the structural features of ICC networks has previously been developed. However, the analysis has been limited to the analysis of ICC structure in 2D images. A 3D framework for quantifying and visualising these ICC networks could provide a valuable tool to elucidate the pathophysiology of GI motility disorders.
In our analysis, 3D visualization techniques namely, 3D structure tensor analysis, 3D Fourier analysis, 3D Graph Network, capable of providing whole-mount gastric antrum tissue imaging representations of proximal and distal regional descriptors based on fluorescence data acquisition have been developed.
Using the murine stomach as a model, the methods outlined in this paper allowed us to analyse and interrogate the gastrointestinal ICC networks structural variations and orientation distribution and better infer and delineate the underlying structural network in unprecedented detail.
Critical aspects of electromagnetic compatibility on board ships
Authors:   Mircea cel Batran Naval Academy, DOBREF V
Published: November 2023

The electromagnetic environment on board a military ship is a bounded space with disturbance sources and receivers. It is defined by the maximum disturbance levels in each interior compartment and on the ship's decks. The electromagnetic environment on board a ship is extremely complex, as it depends to a large extent on the density of equipment on board, the characteristics of the equipment installed (frequency bands, power, modulation types, etc.), the measures to prevent electromagnetic radiation pollution taken by designing the ship in such a way that the electromagnetic field strength inside the ship is as low as possible, with reduced risks to the normal operation of the equipment on board and to the personnel on board. The installation of radars in the on-board electromagnetic environment requires an analysis of the electromagnetic compatibility standards that apply to them. To prevent electromagnetic interference in such systems involves describing the composition of the environment and the interaction between different components. The paper presents a risk-based characterisation of the on-board electromagnetic environment for electromagnetic compatibility analysis.
Case study on the shaft line alignment for a 180 000 tdw bulk carrier vessel
Authors:   Mircea cel Batran Naval Academy, Pintilie A.
Published: November 2023

Alignment means the determination of displacements and breaks between two shafts and their elimination so that the geometric axes of the shafts become approximately collinear, and the deviations are within the permissible limits. This paper presents the methodological steps of the shaft line alignment (as a case study for a bulk carrier vessel of 180 000 tdw) through two classic approaches: with the help of a ruler and feeler gauge (templet) respectively with the help of dial gauge. Comparative analysis of the performances of the two methods, can provide essential information to an engineer in choosing the optimal option for alignment of the shaft lines both in the case of vessels in service and, mainly, in the case of new building’s. The originality of the work consists in carrying out the detailed calculations for displacements and breaks, with the graphical highlighting of the calculated values in the limit allowed intervals. Also, for each method are presented and commented the advantages and disadvantages.
GIS applications for modern-style military operations planning
Authors:   Military Academy of the Armed Forces, Chisinau, R. of Moldova, MARIT E
Published: November 2023

The primary objective of the article is to reflect the practical necessity and possibilities of using GIS software for planning of military operations in the contemporary information environment. The results analysed by the GIS platforms can be used by the specialists in all fields of operational planning by providing the requested data that can improve the performance of operational planning. The obvious need for the development process of the operational planning system in the context of the adoption of planning procedures appears as an opportunity, especially in the current stage of the reformation of the National Army. The geographical characteristics of the area of operation are thoroughly analysed from all available geographical sources. Until now, the most effective method of determining the geographical features of the terrain in the area of operation was considered to be reading from printed topographic maps, which included a series of additional determinations and analyses that were carried out through complex and long-lasting procedures. Accordingly, this fact was not allowing quick decision-making, and often, erroneous analysis of the terrain could lead to incorrect deductions that required commanders of all levels to make wrong conclusions, accordingly to expose them by orders.
Online Teaching and Learning: A Conversation about Digitalisation
Authors:   Mircea cel Batran Naval Academy, CIZER L
Published: November 2023

It is generally agreed that the new technologies have brought about a dramatic change in the way work has been performed worldwide in recent years; therefore, adapting teaching/learning materials to the digital environment has become the norm. But what did this entail? Such questions might arise throughout this process: does face-to-face traditional teaching still find its place within the maritime classroom? what novelties does e-learning (as didactic method) bring to it? which digital methods to use? is there a discernable shift from instructor to facilitator of instructional activities?, etc. This paper sets out to report on a close examination of the above-mentioned issues that the field of teaching/learning maritime/naval terminology in English is currently facing, as presented and discussed during a webinar related to this key topic.
Instances of linguistic contact. The impact of French on Romanian maritime terminology
Authors:   Mircea cel Batran Naval Academy, SANDIUC C
Published: November 2023

The linguistic contact between French and Romanian has long been validated. The neologisms borrowed from French seem to have a privileged status, being dominant in the second half of the nineteenth century and early twentieth century. The contact between the two Romance languages contributed not only to the formation of the modern Romanian language, but also to the innovation of specialized languages. French was the language of diplomacy and international trade several centuries prior to the standardization of English as the international maritime language. As a result, many terms of French origin have entered the Romanian maritime vocabulary since the eighteenth century and continue to show strength today, in spite of the English influence. In this paper, we will demonstrate how linguistic contact has influenced the development of Romanian maritime terminology, focusing on the external means of vocabulary enrichment, namely the loan and the calque.
Leadership to Overcome the Limits of Virtual Education at Tertiary Level
Authors:   Piri Reis University
Published: November 2023

The development of technology, increasing innovation in every field and the influx of digital natives into schools and work have inevitably led to dramatic changes in almost every aspect of life. One of the areas where these changes have begun to manifest themselves is leadership. In this study, leadership, which is one of the indispensable prerequisites for an effective education, will be discussed in the context of digital education. For this purpose, the characteristics of a leader who aims to maximize student satisfaction and educational achievement in the digital classroom context are investigated. In addition to the literature review, the opinions of experienced teachers were also taken into consideration while collecting the data. The findings reveal that the skills that a good e-leader should possess can be categorized under six headings. These are consistency, inclusiveness, empathy, technological and pedagogical competence, and strong ethical values. The study also explores what each group encompasses and what skills good digital leadership may require in the coming years.
Comparative Teaching/ Evaluation Methods in Simulation Didactic Activities
Authors:   Piri Reis University, DEMIREL E
Published: November 2023

In traditional teaching, the instructor provides information and lectures to the learners. This method does not consider the different learning styles and preferences of individuals. It assumes that all learners have similar learning styles and can learn by hearing or seeing. Didactic teaching refers to a teaching approach where the teacher is the primary source of information and directs the learning process. In this approach, the teacher assumes the role of an expert and imparts knowledge to the students in a one-way communication process, with little or no interaction or collaboration. Simulation didactic activities are an effective way to prepare students and professionals for realworld situations by providing a safe environment where they can practice and gain experience. However, the effectiveness of simulation activities depends on the quality of teaching and evaluation methods used. The aim is to make a comparative study of the teaching and evaluation methods used in the simulator training which will ensure quality learning.
The Importance of Mentoring in Building the Professional Excellence in Maritime Sector
Authors:   Mircea cel Batran Naval Academy, COJOCARU C L
Published: November 2023

The present study is seeking to explore the conceptual perspectives and the practicaloperational aspects of the mentoring process with an emphasis on its intrinsic achieving mechanisms, peculiar for two distinct types of learning and training processes: the cognitive and the social dimensions. The authors have considered the mentoring process in the broader scope of the social learning theory, which describes it as an essential element in the context of growth, development, maturation throughout life, complementary to the specific learning context of other processes such as: coaching, training, tutoring, consulting.
On the particularities of the maritime education
Authors:   ”Dunarea de Jos” University, NOVAC V
Published: November 2023

The paper figures out the peculiarities of the maritime learning system considering the actual challenges and requirements of both merchant and naval seafarer professions with risks of accidents, war or conflict zones, sea deriving mines, robbery, and piracy with their plethora of negative intricacies on seafarers life and impacting the life and wellbeing of their families, too. The article also focuses on reducing maritime strain and increasing marine profession attractivity in a complex environment with demanding positions regarding erratic pandemic situations or a global economy changing continuously. Not at last, computer-based or simulator training is considered beneficial for maritime education.
https://www.anmb.ro/buletinstiintific/buletine/2023_Issue1/02_EEA/169-177.pdf
Authors:   Department of Economic Informatics and Cybernetics, Bucharest University of Economic Studies, BARA A
Published: November 2023

The Photovoltaic (PV) systems are more present in the communities’ landscape providing energy to the consumers, public buildings, municipalities, and industry, smoothen the electricity prices fluctuations and reducing the dependency on the public grid. They are reliable energy sources for boats and ships as some of the PV technologies are flexible and can be located on plane surfaces or even on the water surface especially when the ships dock at sea or at the seashore. However, the operation of PV systems depends on several weather factors, and it is important to predict their operation to manage the controllable load. Furthermore, it is essential to know if the PV systems generate in surplus or additional energy is required to cover the load. The surplus can be offered for local trading or aggregated and offered for centralized markets. Therefore, in this paper, we aim to predict the output of the PV systems using machine learning algorithms and recurrent neural networks (RNN), especially a multivariate Long Short-Term Memory (LSTM) model. Data extraction, feature engineering, and forecast of the PV power are depicted and the simulations are performed using 4 PV systems located in Constanta County. The results are assessed with prediction performance metrics such as RMSE, MAPE, etc.
System based on autonomous aerial and maritime surface vehicles to identify sea mines and support the intervention team in the neutralization mission
Authors:   Mircea cel Batran Naval Academy, DOBREF V
Published: November 2023

As naval forces continue to be increasingly present in today's operational environment, European maritime forces are poised to successfully exploit autonomous mine countermeasures (MCM) technology, not only to save manpower but also to increase operational efficiency. Successfully detecting and removing mines from the maritime environment (especially drifting mines, which have re-emerged in the spotlight following the outbreak of war in Ukraine in February 2022) remains a key requirement for maritime forces trying to maintain the security of waterways and oceans around the world. The overall objective of the project, which is the subject of this paper, is to develop and integrate autonomous means (UAVs and USVs) into the concept of action of specialized forces for the search and identification of sea mines. As a starting point in the definition of the overall objective, it has been taken into account that the intervention of specialized forces to neutralize explosive devices involves a series of complex actions, including search, detection, identification, location-based assessment, safe destruction/neutralization, recovery, and destruction of improvised explosive devices or munitions.
Appraisal of irrigation land suitability of semi-arid climatic zone of Rajasthan, India
Authors: Mishra Leena Rani , Singh P. K. , Kothari Mahesh , Bhakar S. R. , Yadav K. K. , Meena S. S.
Published: November 2023

Planning how to use the land resources that are available for irrigation is crucial for reducing the problem of food security. Analytical hierarchy process methodologies were used to undertake an analysis of the appropriateness of land using the GIS approach. Each parameter's weight was assessed using a 6 × 6 pairwise comparison matrix because six parameters, including slope, distance to the nearest road, land use land cover, population density, soil texture and rainfall deficit, are taken into account. After all, the weighted overlay approach of the GIS application was used to create the ultimate land suitability map for irrigation. Using the natural break classification approach, the final map was divided into land suitability classes. Of the entire region, 12.9% fell into the highly suitable (S1) class, 85.14% fell into the moderately suitable (S2) class, and 2.57% fell into the least suitable (S3) class. The finding of the study will play a significant role in performing irrigation taking into account the input parameters and ultimately defining suitable land classes and lands that may be used in accordance with current irrigation technology.
Echocardiographic Evaluation of the Right Heart in Pulmonary Hypertension
Authors: Kusner Jonathan , Krasuski Richard A.
Published: November 2023

Pulmonary hypertension (PH) is characterized by increased right ventricular (RV) afterload, which is accommodated early by dramatic increases in RV contractility to maintain right ventriculoarterial coupling. Related to its tissue biology, characteristics of RV contractility differ from those of the left ventricle (LV). As the RV undergoes adaptation in PH, echocardiographic signs emerge which can help identify PH and can be reassessed to noninvasively prognosticate outcomes in PH. Many of these indices can be calculated from standard echocardiographic views without significant modification to scanning procedures. This review will discuss contemporary diagnosis of PH, highlighting the role of echocardiography in this process. We will describe the differences between the LV and RV, including adaptations of the RV in PH, and how these factors impact echocardiographic assessment. We will conclude with a discussion of specific echocardiographic parameters and describe their role in diagnosis and reassessment. Routine assessment of the right heart improves noninvasive risk stratification in PH, may reduce delays in diagnosis, and ultimately may impact the significant and potentially modifiable disease burden in this patient population.
Nonpharmacological Management of Heart Failure
Authors: Stewart Traci
Published: November 2023

Self-care abilities in patients with heart failure (HF) are directly related to quality of life and outcomes such as hospitalizations and mortality. Patient education is essential in helping patients gain knowledge and skills to become successful in self-care. As the trajectory of the patient’s course changes, the HF team members identify barriers, help the patient adapt, and work toward desired goals. Communication and shared decisions about prognosis, symptom management, and treatment options require the HF team to connect with patients and have difficult conversations that can be facilitated with palliative care consultations.
Social and environmental issues related to the mining industry in the Central African Republic
Authors: Zang Mengue Lucien Antoine , Higueras Higueras Pablo León
Published: November 2023

Considering the differences between the European and African continents concerning the management of the mining production sector, we decided to carry out this study with the main objective of demonstrating that, in Africa, mining can improve the quality of life of the populations where it develops and, at the same time, it is possible to respect the environment, which is our main wealth. To achieve these objectives, it is necessary to present the mining activity of the continent, emphasizing both the negative aspects and its strong points. The most important thing is to make a good diagnosis of the situation, which will allow us to cure our “patient”, that is, African mining production. Therefore, it is important that these states have access to the maximum amount of information and technical solutions that facilitate their decision for a better management of their mineral resources and, by extensi on, the improvement of the living conditions of millions of Africans who still live below of the poverty threshold. Today, the African continent is experiencing a great revolution, and many governments are considering reviewing the mining contracts signed with the multinationals that exploit their resources. The Central African Republic is not to be outdone; despite its strong mining potential it has never really been able to take off. Today, in addition to poverty, a war has been set up directly related to the exploitation of mineral resources. People who were working for themselves yesterday are enslaved by militias that not only destroy nature, but also social cohesion.
Crystal Structure Determination of Nucleotide-sugar Binding Domain of
Human UDP-glucuronosyltransferases 2B10
Authors: Yin Xinli , Lu Xi , Qi Xudan , Tu Yuxi , Zhang Na , Yang Yuan , Chen Xiabin , Tong Junsen
Published: November 2023

Background:

UDP-glucuronosyltransferases (UGTs) play a crucial role in maintaining
endobiotic homeostasis and metabolizing xenobiotic compounds, particularly clinical drugs. However,
the detailed catalytic mechanism of UGTs has not been fully elucidated due to the limited
availability of reliable protein structures. Determining the catalytic domain of human UGTs has
proven to be a significant challenge, primarily due to the difficulty in purifying and crystallizing
the full-length protein.

Objective:

This study focused on the human UGT2B10 C-terminal cofactor binding domain, aiming
to provide structural insights into the fundamental catalytic mechanisms.

Method:

In this study, the C-terminal sugar-donor binding domain of human UGT2B10 was purified
and crystallized using the vapor-diffusion method. The resulting UGT2B10 CTD crystals displayed
high-quality diffraction patterns, allowing for data collection at an impressive resolution of
1.53 Å using synchrotron radiation. Subsequently, the structure of the UGT2B10 CTD was determined
using the molecule replacement method with a homologous structure.

Results:

The crystals were monoclinic, belonging to the space C2 with unit-cell parameters a =
85.90 Å, b = 58.39 Å, c = 68.87 Å, α = γ = 90°, and β = 98.138°. The Matthews coefficient VM
was determined to be 2.24 Å3 Da-1 (solvent content 46.43%) with two molecules in the asymmetric
unit.

Conclusion:

The crystal structure of UGT2B10 CTD was solved at a high resolution of 1.53 Å, revealing
a conserved cofactor binding pocket. This is the first study determining the C-terminal cofactor
binding domain of human UGT2B10, which plays a key role in additive drug metabolism.
Inflammation and Mental Health Disorders: Immunomodulation as a Potential
Therapy for Psychiatric Conditions
Authors: Safari Hanieh , Mashayekhan Shohreh
Published: November 2023

Mood disorders are the leading cause of disability worldwide and their incidence has significantly
increased after the COVID-19 pandemic. Despite the continuous surge in the number of people diagnosed
with psychiatric disorders, the treatment methods for these conditions remain limited. A significant number of
people either do not respond to therapy or discontinue the drugs due to their severe side effects. Therefore, alternative
therapeutic interventions are needed. Previous studies have shown a correlation between immunological
alterations and the occurrence of mental health disorders, yet immunomodulatory therapies have been barely
investigated for combating psychiatric conditions. In this article, we have reviewed the immunological alterations
that occur during the onset of mental health disorders, including microglial activation, an increased number
of circulating innate immune cells, reduced activity of natural killer cells, altered T cell morphology and
functionality, and an increased secretion of pro-inflammatory cytokines. This article also examines key studies
that demonstrate the therapeutic efficacy of anti-inflammatory medications in mental health disorders. These
studies suggest that immunomodulation can potentially be used as a complementary therapy for controlling
psychiatric conditions after careful screening of candidate drugs and consideration of their efficacy and side effects
in clinical trials.
Role of Cerium Oxide Nanoparticles and Doxorubicin in Improving Cancer
Management: A Mini Review
Authors: Girigoswami Agnishwar , Adhikesavan Harini , Mudenkattil Shurfa , Devi Sobita , Girigoswami Koyeli
Published: November 2023

abstract:

Cancer is one of the significant issues with public health and the second leading cause of death
worldwide. The three most lethal cancers in the general population are stomach, lung, and liver cancers, in
which lung and breast cancers cause the majority of cancer-associated deaths among men and women, respectively.
CeO2 nanoparticles have a cytoprotectant effect in normal cells and a cytotoxic effect in cancer cells
that enables them to induce the reactive oxygen species (ROS) production within cancer cells, which in turn develops
reactive nitrogen species (RNS) that interfere with intracellular activities, and this property makes them
an excellent anticancer agent. Because of its biofilm suppression, free radical scavenging ability, redox activity,
and other unique properties, attention has been bestowed on cerium oxide nanoparticles as a potential alternative
to solve many biomedical issues in the future. This review mainly focuses on the combinatorial effect
of cerium dioxide nanoparticles and Doxorubicin in cancer management.
A Comprehensive Review on Phytochemistry and Pharmacology ofRosaSpecies (Rosaceae)
Authors: Fayaz Faheem , Singh Kanwaljeet , Gairola Sumeet , Ahmed Zabeer , Shah Bhahwal Ali
Published: November 2023

The Rosa L. genus is a significant plant family in the Rosaceae group, consisting of around 200 species, primarily shrubs. In India, it has 37 species, most located in the Western Himalayan region of Jammu and Kashmir and Himachal Pradesh. Roses are highly regarded for their beauty and growth and are popular worldwide for their nutritional, therapeutic, ornamental, and cosmetic value. The rose hips are utilized in creating various food and drink items, such as jams, jellies, teas, and alcoholic beverages. The Rosa species has various pharmacological activities, including anti-inflammatory, antidiabetic, hepatoprotective, antimicrobial, anti-proliferative/anticancer, anti-arthritic, neurological, and anti-obesity activity. This review aims to provide an in- -depth overview of the phytochemistry and pharmacology of the Rosa species in India, focusing on Rosa indica L., which has significant potential for future chemical and biological research.
Clinical Applicability of Autologous Chondrocyte Implantation for the
Treatment of Osteochondral Defects: A Meta-analysis
Authors: Almohaileb Faisal I. , Rasheed Zafar
Published: November 2023

Purpose:

Osteoarthritis and other joint disorders are the leading cause of disability in
the elderly and the treatment of joint lesions is challenging. Autologous chondrocyte implantation
(ACI) has been reported with variable effects for the treatment of osteochondral and other joint lesions.
In this study, we performed a meta-analysis of the recent literature to determine the clinical
applicability of ACI for osteochondral defects.

Methods:

A meta-analysis was performed on the recent literature showing the effects of ACI on
osteochondral defects. The PUBMED, ScienceDirect and Google Scholar databases were used to
identify eligible studies from Jan 2010 to Sep 2022. Both fixed and random models of meta-analysis
were applied with all reported scoring systems to quantify the effectiveness of ACI on osteochondral
defects.

Results:

The pool data of 965 patients as a case series after ACI from a fixed model showed a significant
improvement in the osteochondral defects (odds ratio = 8.75, 95%CI = 7.127 to 10.743, p
= 0.000). These results were further verified by a random model of meta-analysis. The data also
showed a substantial heterogeneity among the studies used in the meta-analysis (Q-value =
160.41, I-squared = 87.53, p = 0.000). Furthermore, this meta-analysis also compared different
ACI procedures with different scoring systems but the overall outcome remains the same as ACI
was found to be useful for the healing of the osteochondral defects.

Conclusion:

This meta-analysis of 965 case series revealed that the ACI markedly improved the
damage osteochondral defects scores but the optimal treatment is still controversial, therefore further
studies are needed to validate these findings in a clinical setting.
Benign Multicystic Peritoneal Mesothelioma: Two Rare Cases and Review of the
Literature
Authors: Incesu Mustafa Mehmet , Ucar Murat , Kozan Ramazan , Simsek Berkay , Esendagli Guldal
Published: November 2023

Background::

Benign multicystic peritoneal mesothelioma is a multiloculated cystic mass which originates from the peritoneum. This rare tumor is usually seen
in women of childbearing age and has a high recurrence rate after surgery.

Case Presentation::

We present two benign multicystic peritoneal mesothelioma cases with different imaging modalities, which were also pathologically proven.

Conclusion::

The imaging features which may be diagnostic should be well known as there are very few reports regarding this entity
Determination of Novel SARS-CoV-2 Inhibitors by Combination of
Machine Learning and Molecular Modeling Methods
Authors: Güner Ersin , Özkan Özgür , Yalcin-Ozkat Gözde , Ölgen Süreyya
Published: November 2023

Introduction::

Within the scope of the project, this study aimed to find novel inhibitors
by combining computational methods. In order to design inhibitors, it was aimed to produce molecules
similar to the RdRp inhibitor drug Favipiravir by using the deep learning method.

Method::

For this purpose, a Trained Neural Network (TNN) was used to produce 75 molecules
similar to Favipiravir by using Simplified Molecular Input Line Entry System (SMILES) representations.
The binding properties of molecules to Viral RNA-dependent RNA polymerase (RdRp)
were studied by using molecular docking studies. To confirm the accuracy of this method, compounds
were also tested against 3CL protease (3CLpro), which is another important enzyme for the
progression of SARS-CoV-2. Compounds having better binding energies and RMSD values than
favipiravir were searched with similarity analysis on the ChEMBL drug database in order to find
similar structures with RdRp and 3CLpro inhibitory activities.

Result::

A similarity search found new 200 potential RdRp and 3CLpro inhibitors structurally similar
to produced molecules, and these compounds were again evaluated for their receptor interactions
with molecular docking studies. Compounds showed better interaction with RdRp protease
than 3CLpro. This result presented that artificial intelligence correctly produced structures similar
to favipiravir that act more specifically as RdRp inhibitors. In addition, Lipinski's rules were applied
to the molecules that showed the best interaction with RdRp, and 7 compounds were determined
to be potential drug candidates. Among these compounds, a Molecular Dynamic simulation
study was applied for ChEMBL ID:1193133 to better understand the existence and duration of the
compound in the receptor site.

Conclusion::

The results confirmed that the ChEMBL ID:1193133 compound showed good Root
Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), hydrogen bonding, and
remaining time in the active site; therefore, it was considered that it could be active against the
virus. This compound was also tested for antiviral activity, and it was determined that it did not
delay viral infection, although it was cytotoxic between 5mg/mL-1.25mg/mL concentrations. However,
if other compounds could be tested, it might provide a chance to obtain activity, and compounds
should also be tested against the enzymes as well as the other types of viruses.
Nanotechnology-based Assays for the Detection of Cancer through Sputum
Authors: Singh Dilpreet
Published: November 2023

Cancer remains a formidable global health challenge, underscoring the critical need for
early and accurate diagnostic tools. In recent years, nanotechnology has emerged as a promising
frontier in cancer detection, offering innovative approaches to enhance sensitivity, specificity, and
convenience in diagnostics. This comprehensive review delves into the intersection of nanotechnology
and sputum-based assays for cancer detection. Sputum, a readily accessible biomarker source, has
gained increasing attention due to its potential to house early cancer biomarkers. By harnessing the
unique properties of nanoparticles, this review explores how nanotechnology is revolutionizing sputum-
based cancer detection. We examine the intrinsic attributes of sputum as a diagnostic fluid, the
diverse applications of nanoparticles, and the evolving landscape of cancer-specific biomarkers.
Moreover, we provide insights into various nanotechnology assay techniques and their clinical implications
while highlighting the challenges and future prospects in this dynamic field. This review
aims to elucidate the transformative impact of nanotechnology on cancer diagnostics through sputum,
offering a roadmap towards earlier and more accurate cancer detection.