bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical efficacy, safety and tolerance of the Kerawort (imiquimod) cream used for treatment of anogenital warts
Authors: Rakhmatulina M. R. , Kubanov A. A. , Samtsov A. V. , Sukharev A. V. , Bondar O. I. , Semenenko A. V.
Published: February 2022

Goal of the study. To assess the efficacy and safety of Kerawort (Imiquimod, 5% cream for topical administration) vs. placebo used for treatment of anogenital warts. Methods and materials. The single-blind comparative placebo-controlled study involved 90 patients (44 female and 46 male) with anogenital warts. The patients were randomized into two groups: the main group (n = 45) receiving treatment with Kerawort (Imiquimod, 5% cream) and the control group (n = 45) receiving placebo. The diagnosis was confirmed by the identification of human papillomavirus by the polymerase chain reaction method. The patients received treatment three times a week until clinical signs disappeared but for not more than 16 weeks. Results. In 95.6% of patients from the main group and 8.9% of patients from the control group, anogenital warts disappeared completely or the quantity/area of pathological eruptions reduced at least by 70% as compared to the baseline. No relapses occurred during the treatment and follow-up period (28 days after the completion of treatment) in patients from the main group. An increase in the size and/or area of anogenital warts and/or development of new eruptions on the skin and mucous membrane of the genitals were recorded in 11.1% of patients from the control group. No serious adverse events were revealed during the study. Conclusion. Higher efficacy (р < 0.0000001) and comparable safety of Kerawort (Imiquimod, 5% cream for topical administration) used for treatment of anogenital warts vs. placebo were reliably established.
Urogenital chlamydia infection in women: patient management tactics according to present-day foreign and Russian recommendations
Authors: Khryanin A. A.
Published: February 2022

The article present data on current approaches to laboratory diagnostics and treatment of urogenital chlamydia infection in women. According to Russian and foreign guidelines, azithromycin, josamycin and doxycycline monohydrate belong to the most efficient antimicrobial drugs for the treatment of urogenital chlamydia infection in non-pregnant women. As for the treatment of pregnant patients suffering from this pathology, azithromycin and josamycin are the most optimal drugs in terms of safety and treatment efficacy according to both Russian and foreign guidelines.
Duration of the determination of specific Igm antibodies in primary syphilis patients after treatment
Authors: Rotanov S. V. , Ermatova F. A.
Published: February 2022

It was carried out a study with ALISAIgM of 341 samples of the blood, obtained from the patients with the early forms of syphilis 3-36 months later the end of adequate antibacterial therapy with the purpose for studying the duration of circulation in the blood of specific antibodies IgM to the antigens T. pallidum after the treatment. It was shown gradual reduction of the levels of the anti-treponema antibodies of the class M in the blood with an increase of the period of observation and their total elimination to the period of 36 months. It was not established reliable differences within the dynamics of a decrease in the levels of specific IgM and the periods of negativation of the ALISAIgM results depending on the adequate method of antibacterial therapy.
Justification of the efficacy of antibacterial therapy for the treatment of chronic endometritis
Authors: Tapilskaya N. I. , Karpeyev S. A. , Gaidukov S. N.
Published: February 2022

A review of studies on chronic endometritis enables the authors to conclude that bacterially contaminated endometrium is the reason causing reduced fertility in case of confirmed subclinical inflammation. Chronic subclinical inflammation of the endometrium is often associated with genital endometriosis, which apparently leads to abnormal uterine bleedings. The identification of a microbial agent in case of endometritis in the routine outpatient practice is not mandatory because global experience including high-level evidence-based studies confirms the expediency of an empirical therapy based on minimum clinical criteria; otherwise, there may be irreversible consequences for the reproductive system. A preventive antibacterial therapy during the pre-conception period in infertile patients suffering from recurrent miscarriages is an efficient method to prevent reproductive losses.
Trends in Russian and USSR Venerology Development (1950-1959)
Authors: Belova-Rakhimova L. V. , Prokhorenkov V. I. , Gusey T. N.
Published: February 2022

The article presents the history of venerology in Russia and USSR in 1950-1959.
Gonococcal infection: diagnostics and therapy tactics according to russian and foreign clinical recommendations
Authors: Rakhmatulina M. R.
Published: February 2022

The article discusses current approaches to management of adult patients suffering from the gonococcal infection according to federal (national) clinical recommendations of the Russian Society of Dermatovenerologists and Cosmetologists (2013), European Guideline on the Diagnoses and Treatment of Gonorrhoeae in Adults (2012) and Sexually Transmitted Diseases Treatment Guidelines (CDC, 2010). The article describes indications for gonococcal infection examinations and diagnostics methods presented in Russian and foreign recommendations. The article describes the treatment regimen based on N. gonorrhoeae antibacterial resistance monitoring results.
Clinical application of gancyclovir in the complex treatment of the different forms of true acantholytic pemphigus
Authors: Baltabaev M. K. , Baltabaev A. M.
Published: February 2022

Short summary and results of the own clinical observations on efficacy of developed complex method on the treatment of true acantholytic pemphigus composed of traditional immunosuppressive therapy and antiviral remedy - gancyclovir are presented. The etiology of herpesvirus infection had been discussed in the pathogenesis of the disease.
A comparative analysis of the efficacy of a combined topical therapy in patients suffering from mild to moderate papulopustular acne
Authors: Kondratiyeva YU. S. , Shepileva T. N. , Kokina O. A. , Subbotin YE. A.
Published: February 2022

The goal of this study was to compare the efficacy and safety of Azelic (15% gel of azelaic acid), 1% Clindamycin gel and 0.1% Adapalene gel as a complex therapy in patients suffering from mild to moderate acne. Materials and methods. An open-label comparative study involving 40 patients suffering from mild to moderate papulopustular acne. The study was based on the medical history, a questionnaire form, physical examination results, assessment of morphological and functional skin parameters and dynamics of the life quality index (DLQI). Key findings and conclusions. Positive dynamics of the skin process was observed by the end of Week 6 of the treatment depending on the combination treatment type. The administration of Azelic gel resulted in an increased moisture level of the skin and reduced sebometry indices, skin relief intensity and pigmentation level.
Clinical and morphological diagnostics of skin manifestations in case of graft-versus-host disease
Authors: Krivolapova A. YU. , Smirnova I. O. , Lisukova YE. V. , Moiseyev I. S. , Belousova I. E. , Baikov V. V.
Published: February 2022

The graft-versus-host disease is a life-threatening complication of allogeneic bone marrow transplantation, which demands fast and reliable diagnostics. Goal. To study clinical features of the graft-versus-host disease as well as differential and diagnostic value of histological and immunohistochemical signs in skin biopsy samples in case of graft-versus-host disease (GvHD). Materials and methods. The authors made a comparative assessment of clinical data available for patients suffering from acute GvHD (50 patients) and toxic dermatitis (10 patients). Skin biopsy samples taken from patients from both groups underwent postmortem and immunohistochemistry examinations: the drugs were stained with hematoxylin and eosin as well as by using anti-CD3, CD20, CD4, CD8, FOXP3, CD56, CD1a and CD 68 antibodies. Results. Based on the results of clinical data assessments, no significant differences in the groups were revealed. The morphological examination revealed that the number of eosinophils, CD8+, CD1a+, CD3+ and FOXP3+ cells and share of FOXP3+ cells among Т lymphocytes was higher in the group with toxic dermatitis. Conclusion. An integrated assessment of clinical data and morphological examination results accompanied by the analysis of the population composition of the infiltrate is needed to diagnose the acute GvHD.
Treatment of superficial mycosis of glabrous skin of itraconasole
Authors: Tarasova M. A. , Ermoshina E. A. , Nagornova I. V. , Stepanova S. V.
Published: February 2022

The treatment of fungal infections of the skin is actual problem of modern dermatology. The goal of the research. The study of the clinical efficacy, tolerance and safety of the use of the systemic antifungal drug itraconazole (Irunin) in treatment of extensive and often recidivic clinical forms of superficial mycosis of glabrous skin. Material and methods. The authors observed 56 patients aged from 18 to 60 with different clinical forms of dermatomycosis (33 - with extensive pytiriasis vesicolor, 13 - with chronic recidivic tinea pedis, 7 - with extensive mycosis of body and large flexures, 3 - with mycosis of different localizations). All patients received monotherapy of itraconazole (Irunin): two capsules (200 mg) once a day for 7 days, then one capsule (100 mg) once a day for 14 days. The duration of the treatment was 21 days. Results. Clinical and mycological recovery was achieved in all number of the cases. Serious unnecessary effects of treatment was not observed. Conclusions. The results of the study have shown high therapeutic efficacy and good tolerability of antifungal drug itraconazole (Irunin) in the systemic treatment of fungal infections of the skin.
Influence of azelaic acid on acne pathogenesis
Authors: Khlebnikova A. N.
Published: February 2022

I In current literature review the physicochemical properties, peculiarities of mode of action and pharmacokinetics of azelaic and influence of azelaic on pathogenetic aspects of acne are characterized.
Efficiency and tolerance of acne therapy using system isotretinoin
Authors: Perlamutrov Yu. N. , Olkhovskaya K. B. , Kokhan M. M. , Keniksfest Yu. V. , Shaibakova Yu. B. , Polyakova N. V. , Topychkanova E. P. , Kashcheeva Ya. V. , Samtsov A. V. , Statsenko A. V. , Belousova I. E. , Khayrutdinov V. R. , Volkova S. V. , Zhukov A. S.
Published: February 2022

Purpose. Determination of efficiency and tolerance of Sotret product in treatment of patients with different clinical forms and severe acne in three clinical investigations. Materials and methods. 103 patients with acne (moderate and severe acne, acne conglobata and acne inversa) were examined and treated. All patients underwent monotherapy with Sotret with clinical effectiveness assessment and records of adverse events. Results. Sotret therapy facilitated clinical remission of acne in 90-100% of cases. Adverse events were easily tolerated and were not serious. Conclusion. Established therapeutic efficiency of Sotret determines its potential in treating various severity and various forms of acne.
Evaluation of the quality of life in patients with alopecia areata and androgenetic alopecia
Authors: Kondrakhina I. N. , Mareeva A. N.
Published: February 2022

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
Seborrheic keratosis and insulin resistans
Authors: Aleksandrova A. K. , Smolynnikova V. A.
Published: February 2022

Regardless of multiple studies performed, aetiology and pathogenesis of seborrheic keratosis (SK) remain unknown. Insulin resistance may play the leading role. For instance, hyperinsulinemia is responsible for development of fibroepithelial polyps and acanthosis nigricans, diseases frequently associated with seborrheic keratosis. The purpose of the investigation is to study clinical factors and carbohydrate metabolism of patients with SK. Material and methods. The results of examination of 130 patients divided in two groups, were presented: 1st group with a single instance of SK (n = 60) and 2nd group with multiple SK (n = 70). All patients underwent histologic examination, analysis of carbohydrate metabolism: blood glucose, plasma insulin, level of glycated hemoglobin, glucose tolerance test; based on the results, advice from an endocrinologist was provided. Results and conclusions. Link between multiple SK and carbohydrate dysbolism was revealed: insulin resistance was found in 85.7% of patients from the 2nd group (16.6% in the 1st group). In our study, the association of multiple SK with fibroepithelial polyps and adiposity has evidenced that the patient suffered from type 2 diabetes mellitus.
Phototherapy of extragenital white spot disease
Authors: Volnukhin B. A. , Znamenskaya L. F. , Kappusheva I. A. , Muradyan N. L. , Dvornikov A. S.
Published: February 2022

Objective. To study the effectiveness of UVA1therapy and PUVA therapy in patients with extragenital lichen sclerosus. Materials and methods. Effectiveness of the phototherapy methods was studied in 12 patients with extragenital lichen sclerosus (8 women, 4 men) aged from 19 to 61 years old with the disease history of 1-25 years. 6 patients received UVA1therapy while 3 patients received general PUVA therapy and 3 patients - local PUVA therapy. All the patients underwent phototherapy in the form of monotherapy. Results. After the treatment clinical improvement was observed in 6 patients from the UVA1 group (100%) and 4 patients from the PUVA group (66.7%), significant improvement of clinical picture and clinical remission were registered in 1 (16.7%) and 2 (33.3%) patients from the PUVA group, respectively. Phototherapy caused partial or full regress of main lichen sclerosus symptoms: sclerosis, induration, erythema, epidermal atrophy and skin hypopigmentation. The tolerability of treatment was satisfying, serious adverse effects were not reported. Conclusion. Conducted research indicates the effectiveness of UVA1therapy and PUVA therapy in patients with extragenital lichen sclerosus. Phototherapy may be a choice in the management of the disease.
Preventing of transfusion syphilis
Authors: Chechetkin A. V. , Danil’Chenko V. V. , Chebotkevich V. N. , Kas’Ianov A. D. , Makeev A. B. , Soldatenkov V. E.
Published: February 2022

Goal of the study. To study the prevalence of syphilis markers in donors in the Russian Federation, and to evaluate the effectiveness of measures to prevent blood transfusion syphilis and other bloodborne infections in the Blood Service in Russia. Materials and methods. Performance analysis of sectoral statistical surveys Russian Ministry of Health in the form number 39, «Report of the station, department of blood transfusion, hospital blood leading procurement» and the explanatory notes to them for the period from 2009 to 2013. Analysis of the results of screening donated blood for markers of syphilis. Results. It was found that the incidence of syphilis markers in donors in the whole of Russia was significantly (p < 0,05) decreased (from 0.79% in 2009 to 0.49% in 2013). However, there was heterogeneity in the proportion of donors with markers of syphilis in different regions of the Russian Federation. (From 0.68 to 0.35%). In 2013, the causative agent of syphilis markers are more often detected in donors of the North Caucasus and Siberian Federal Districts, seldom in donors in the North-Western and Urals Federal District. Hence, there remains a certain risk of transfusion transmission of syphilis. In recent years, widely implemented method viral inactivation of plasma and platelet concentrate. In 2013, the procedure viral inactivation subjected to 8% of the total issued for transfusion platelet concentrate. Conclusion. There remains a certain risk of transfusion transmission of syphilis. Further implementation of the methods of inactivation of pathogens in Blood Service of Russia will also contribute to reducing the risk of blood-borne transmission of Treponema pallidum.
Atopic dermatitis in children. A current algorithm for the disease treatment and control
Authors: Proshutinskaya D. V.
Published: February 2022

The article discusses key aspects of the pathogenesis of atopic dermatitis and issues of the selection of pathogenetically substantiated therapy methods. The authors provide data on the efficient use of basic drugs used to treat dermatosis in children - topical glucocorticosteroids and calcineurin inhibitors. The authors also describe a current algorithm for using topical calcineurin inhibitors during the period of an exacerbation of atopic dermatitis and to prevent relapses.
A case of psoriasiform syphilid (from clinical practice)
Authors: Koshkin S. V. , Chermnykh T. V. , Kovrova O. S. , Ryabov N. YU.
Published: February 2022

The current article analyzes a clinical case of general psoriasis-form syphilid in a 28-year patient. Attention is paid to combination of exudative psoriasis and syphilis in in a sex partner. Problems of differential diagnosis for clinical evidence of secondary syphilis and psoriasis were analyzed.
PASI (Psoriasis Area and Severity Index) in the evaluation of the clinical manifestations of psoriasis
Authors: Kubanov A. A. , Karamova A. E. , Znamenskaya L. F. , Chikin V. V. , Kondrashova V. V.
Published: February 2022

Psoriasis is one of the most prevalent chronic inflammatory skin diseases. The severity of its clinical manifestations can vary greatly. Objective assessment of psoriasis severity is required to select an adequate therapy. One of the simplest and most consistent methods used to determine psoriasis severity is to calculate the PASI (Psoriasis Area and Severity Index). This index is based on the doctor’s determination of the sum of indices showing the intensity of the main symptoms of psoriasis: erythema, infiltration and peeling in view of the affected skin area. The PASI can also be used to assess the efficacy of treatment for psoriasis patients.
Human papilomavirus infection in couples. A discussion
Authors: Lysenko O. V. , Ziganshin O. R. , Shevchenko S. Yu.
Published: February 2022

In the Russian literature, insufficient attention is given to the study of the flow of human papillomavirus infection in couples. The aim of the study was to establish the frequency of infection with oncogenic HPV types and clinical manifestations of human papillomavirus infection in regular sexual partners. Surveyed 38 couples who are regular sexual partners in the past three years and denying unauthorized sex. PVI revealed at 70.9 per cent of women who had contact with an infected partner and 79.8 per cent of men. The average age for first sexual intercourse in women was 18.2 years, men - 16.7 years. 80% of men before marriage had more than 5 sexual partners. In 37 of 38 pairs of HPV types of high oncogenic risk coincide. The most frequently detected HPV type 16, are a few less - HPV 51, 31 and 39. Clinical manifestation of HPV infection among sexual partners of the 38 couples not identified, subclinical form of infection in women and men after colposcopy and peniscopy were found with equal frequency (18.4%) and (15,8%), respectively. The descriptions of peniscopy in men with HPV of high oncogenic risk was done.
Systemic therapy in patients with severe rosacea
Authors: Bakhlykova E. A. , Filimonkova N. N. , Matusevich S. L.
Published: February 2022

Rosacea is a polietiologic disease with a complex pathogenesis, resulting in the problem is the selection of therapeutic tactics, especially in severe disease. The result of the study revealed that the isotretinoin treatment for rosacea had a positive result, even in the absence of the effect of previous systemic antibiotic therapy. Aim of the study. To study the effect and tolerability of systemic isotretinoin treatment for severe rosacea that is resistant to antibiotic therapy. Materials and methods. Under the supervision and treatment were 16 patients with severe course of rosacea, 14 of them had pustules and papules and 2 - fimatodes subtype. The severity was estimated by the method a 4-point scale proposed by V.P. Adaskevich, and was in average 18.6 points. All patients had a duration of 3 ± 1.2 years for systemic antibacterial therapy (clarithromycin, Ornidazole) with insufficient effect in the past. All patients (n = 16) was conducted therapy with isotretinoin (using Aknekutan). Daily dose was calculated on body weight, the initial dose was 0.2-0.3 mg/ kg, with subsequent dose reduction. Topically patients received clindamycin phosphate gel 1% treatment (5-7 days), then metronidazole 1% cream (Rosamet) 1-2 times a day. The duration of therapy ranged from 3 to 5 months. Results. After the course of therapy using Aknekutan remission or significant improvement was achieved in 87.5% of cases. The severity of the disease fell to 6.5 points, i.e. 2.8 times. Conclusion. Aknekutan showed a high therapeutic effect in severe rosacea, so it can be recommended to patients with resistance to conventional therapy. As external therapy, and supportive treatment patients are recommended - cream metronidazole 1% (Rosamet) and adequate skin care, photoprotective creams.
On the 95th anniversary of the department of dermatovenereology and the 100th anniversary of Perm State Medical University by academician E.A. Wagner
Authors: Elkin V. D. , Sedova T. G. , Plotnikova E. V. , Kopytova E. A.
Published: February 2022

September 2016 marks 95 years since the foundation of Dermatology and Venereology Department in Perm State Medical University. This article provides information on its organization, formation and development, the brightest and the most outstanding representatives of the department, main directions of scientific, educational and therapeutic activities.
Chronic inflammation, insulin resistance, psoriasis - which have in common?
Authors: Rasin M. S.
Published: February 2022

Psoriasis is recognized as system immune inflammatory disease at a certain genetic basis. It was found that psoriasis develops under the influence of chronic systemic inflammation low intensity (low grade inflammation) that induced insulin resistance, and is one of the clinical forms of the Immune Metabolic Disease (IMD), along with atherosclerosis, hypertension, type 2 diabetes, obesity and many other diseases, whose tight relationship with psoriasis are installed. Knowledge of the etiology, pathogenesis and molecular mechanisms of communication with other clinical forms of the IMD opens up new ways of prevention and treatment of psoriasis. Please note that other diseases associated with psoriasis, occurring hidden, often have greater predictive value for the life and health of the patient than mild or moderate forms of psoriasis, and be not limited to ascertaining the diagnosis and symptomatic treatment and actively participate in prevention. Debated question of the application of funds, suppressing systemic inflammation and insulin resistance in the treatment of psoriasis.
Basal cell skin cancer with sebaceous glands nevus: clinical presentation and differential diagnostics
Authors: Karacheva Y. V. , Guzey T. N. , Yakovleva T. A. , Smykova A. N. , Vinnik Y. U.
Published: February 2022

The description of two clinical cases of basal cell skin cancer, which developed against the background of a nevus of sebaceous glands.The article reflects the clinical features and criteria for the differential diagnosis of pigmented form of basal cell skin cancer.
On the new model of funding and quality assurance of dermatovenereologic care
Authors: Martynov A. A. , Stadchenko N. N. , Vlasova A. V.
Published: February 2022

The article deals with modern approaches to organization of delivery and financial support of high-tech medical care on the profile of “dermatovenereology”, and with introduced mechanisms for quality assurance of medical care and independent evaluation of the services provided.
Clinical efficasy of L-arginine and ursodeoxycholic acid in the complex treatment of rosacea
Authors: Baltabaev M. K. , Shakirova A. T. , Baltabaev A. M.
Published: February 2022

Under clinical observation were 77 patients suffered from different clinical forms of acne rosacea that using L-arginin and Ursodeoxycholic acid had treated All patients have functional and organic disturbances of hepatobiliary system before treatment. Complex treatment including L-arginin and Ursodeoxycholic acid led to improvement of balance of liver enzymes and lipid fractions in peripheric blood of investigated patients.
Topical antibacterial medications for therapy of patient with acne
Authors: Pashinjan A. G. , Shahnovich A. A.
Published: February 2022

Problems of acne pathogenesis are reviewed. Efficacy evaluation and safety use of 1% clindamycin solution at patient with acne are demonstrated.
Improvement of laboratory diagnostics of urogenital chlamydial infection in patients with impaired reproductive functions found to be infected with Chlamydia trachomatis
Authors: Fedorova V. A. , Sultanakhmedov E. S. , Saltykov Y. V. , Utz S. R. , Motin V. L.
Published: February 2022

The dominant role in human infertility has been attributed to sexually transmitted infections (STIs) with a leading contribution of urogenital chlamydial infection (UGCI) caused by Chlamydia trachomatis (CT). the two variants of this pathogen are represented by the wild-type (wtCT) and new Swedish (nvCT) strains containing 377 bp deletion within the cryptic plasmid orf1 gene. Objective. The purpose of the study was investigation of the clinical specimens obtained from the urogenital tract of couples coping with infertility for the presence of genetic material of wtCT and nvCT. Material and methods. Clinical samples (scrapings from the urethra and cervix) obtained from 25 to 41 years old couples (n = 14) were tested for the presence of identifiable wtCT and nvCT chlamydia DNA by monoplex and duplex PCR, specific antigens C. trachomatis in elementary bodies by using immunofluorescence analysis (IFA), while detection of anti-chlamydia antibodies in sera was determined by immunoenzymatic assay (IEA). Results. The nvCT variant with typical deletion of 377 bp within the orf1 gene that belongs to the genovar e subtype E1 was detected in 100% of couples with infertility. The negative results of DNA testing for wtcT were registered in 87.5% of patients from this group, while one individual (12.5%) was likely coinfected with nvCT and wtCT of E1 and D genovars, respectively. The wtCT strains of genovar E (subtypes E1, E2, E6), g (subtypes G1, G2), F (subtypes F1), and K were identified in control group among patients with UGCI. The study revealed difficulties in detection of nvCT by nucleic acid amplification test (NAAT), IFA, and IEA; data on comparison of the efficacy of these methods are presented. Conclusion. Chronic UGCI in patients with reproductive dysfunctions can be caused by nvCT alone or as result of co-infection with nvCT and wtCT. The negative results in NAAT may not 100% correlate with the absence of UGCI that requires further confirmation in tests allowing detection of all known variants of C. trachomatis.
Acquired bullous epidermolysis: complexity of diagnostics
Authors: Al'banova V. I. , Nefedova M. A.
Published: February 2022

The article describes the case of acquired bullous epidermolysis in a woman of 45 years old, suffering from a disease from 2.5 years. As a child, she was diagnosed with herpetiform dermatitis on the base of a clinical picture and histological data. After the period of puberty, when in addition to skin blistering a lesion of the oral mucosa, dystrophy and absence of nail plates, contracture of the 2 fingers of the hands arose, the diagnosis was changed to dystrophic congenital bullous epidermolysis, which did not contradict with re-histological examination of the skin. In order to clarify the diagnosis, another biopsy of the leg skin was performed in 2016. The light microscopy data corresponded to the herpetiform dermatitis or vesicular form of the bullous pemphigoid, the acquired bullous epidermolysis was not also excluded. Indirect RIF allowed to reject the diagnosis of herpetiform dermatitis. The possibility of bullous pemphigoid developing on the background of preexisting congenital bullous epidermolysis was investigated by immunofluorescence mapping with antibodies to 13 structural proteins of the dermo-epidermal junction. Expression of all the studied proteins corresponded to that of healthy individuals, which conflicted with the diagnosis of congenital bullous epidermolysis. Additional immunofluorescence study of the sites of spontaneous cleavage of the biopsy specimen, as well as of n- and u-patterns in the structure of the luminescence line, made possible to exclude the bullous pemphigoid. So, the use of a complex of immunomorphological methods helped to establish the correct diagnosis.
EFFECTIVENESS OF CREAM CONTAINING VERAPAMIL HYDROCHLORIDE, IN THE THERAPY OF RUBTS IN EXPERIMENT
Authors: Okhlopkov V. A. , Skalsky S. V. , Sokolova T. F.
Published: February 2022

The data in respect to efficacy of verapamil-containing scar cream for treatment of hypertrophic and keloid scars are presented in the article. Skin scars were simulated in rats by excision of a full-thickness skin flap size 5x4 cm2 in the center of the back. Upon wound healing and scar formation a daily twofold fomentation of verapamil-containing cream was carried out. Treatment efficacy was checked after 10, 30 and 60 days. The following indices were studied: an area of the scar, its type, consistence, color, sensitivity, and scar microcirculation according to biomicroscopy. The proposed novel method for treatment of hypertrophic and keloid scars with verapamil-containing cream allowed to obtain a sustained clinical result demonstrating a reducing area of the scar by 25%, a physiological scar formation, improving the consistence and scar colour changing to the normal skin colour, its softening and flattening, and pain disappearance. Due to the dermal application, the method was painless, safety and did not affect on the surrounding tissues. According to biomicroscopy a scar remodeling approximated the indices to the level of healthy skin in 93% of rats. The most significant clinical effect the cream with verapamil was observed in experimental animals in 60 days after treatment.
SYSTEM THERAPY OF PSORIASIS IN CHILDREN (PART I)
Authors: Namazova-Baranova L. S. , Murashkin N. N. , Ambarchyan EH. T. , Materikin A. I.
Published: February 2022

We include a review of modern methods of systemic therapy of psoriasis in children, indications for which are moderate and severe forms of psoriasis with PASI 10, skin pathological process that is uncontrollable with topical drugs, skin lesions with functional localization (lesions of genitals, palms and soles, facial skin), erythrodermic psoriasis, pustular psoriasis, psoriatic arthritis. We provide information on the techniques of narrow-band phototherapy (UVB 311 nm) that are used in the treatment of psoriasis in children. We provide data on efficacy, safety, necessary monitoring of clinical and laboratory indicators, peculiarities of vaccination during treatment of children with acitretin, methotrexate, cyclosporine.
Experience of using peroral cosmetic products from the Emolium series in the complex therapy of children suffering from atopic dermatitis
Authors: TEKUCHEVA L V , ZNAMENSKAYA L F
Published: February 2022

The authors summarized the current data on the function of the epidermal barrier, mechanisms of its affection and its role in the development of atopic dermatitis. They present the results confirming the efficacy of complex administration of basic skin care products in the therapy of children suffering from atopic dermatitis. Basic skin care products were cosmetic products from the Emolium series in the form of cream and emulsion as well as skin hygiene products (bath emulsion, cream washing gel).
Cephalosporins of the third generation for the treatment of gonorrhea
Authors: Frigo N V , Guchev I A , Sidorenko S V , Lesnaya I N , Solomka V S , Frigo N V , Guchev I A , Sidorenko S V , Lesnaya I N , Solomka V S
Published: February 2022

The article presents the data on antibiotic resistance and N. gonorrhoeae mechanisms for developing resistance to antimicrobial drugs belonging to different pharmacologic groups and applied for causal treatment of gonorrhea. The article proves the key problem related to the treatment of gonococcal infection in Russia lies in the prevalence of strains being resistant to most of the antibacterial drugs that used to be applied in the clinical practice on a broad scale and efficiently. So, cephalosporins of the third generation are presently the only drug type that N. gonorrhoeae remains sensitive to. Their application ensures the maximum efficacy against the gonococcal infection. According to the presentday international recommendations complying with the WHO criteria as well as accumulated experience, cefixime, a drug belonging to cephalosporins of the third generation, can be a drug of choice for the antibacterial therapy of gonorrhea along with ceftriaxon.
Xerosis and xemose
Authors: Kochergin N G , Kochergin N G
Published: February 2022

This article covers current concepts of the barrier function of skin, major pathophysiological mechanisms of skin xerosis
development, its fillagrin-dependent mutations and major clinical signs by the example of atopic dermatitis. The author
gives recommendations for using moisturizers on the basis of Uriage Thermal Water comprising Xemose Cream, Xemose
Cerate and Xemose Gel-Cream for efficient reduction of extra skin dryness.
A rare case study of a female patient suffering from Kyrle disease (hyperkeratosis follicularis etparafollicularis in cutem penetrans)
Authors: L'vov A N , Katunina O R , Matushevskaya Yu I , Svishchenko S I , Voytsekhovskaya M A , LVOV A N , KATUNINA O R , MATUSHEVSKAYA YU I , SVISHCHENKO S I , VOITSEKHOVSKAYA M A
Published: February 2022

The article presents a literature review and case study of a rare form of dermatitis in a female patient aged 61 - Kyrle disease (hyperkeratosis follicularis et parafollicularis in cutem penetrans). It also provides a detailed description of the clinical picture and differential diagnostics of the disease. The following typical changes were observed based on the results of histological examination: epidermic invaginations filled with corneous masses and areas of focal parakeratosis. Essential improvement in skin process dynamics was achieved against the background of treatment with Acitretin.
A case of the Neu-Laxova syndrome
Authors: Melashenko T V , Milyavskaya I R , Leina L M , MELASHENKO T V , MILYAVSKAYA I R , LEINA L M
Published: February 2022

Neu-Laxova syndrome is a rare lethal genetic disorder characterized by multiple congenital abnormalities, microcephaly
and ichthyosiform skin lesions. The authors describe a case of this syndrome in a newborn baby.
Association of polymorphism of IL12B gene and predisposition to psoriasis among the populationof the Northwestern region of Russia
Authors: Khayrutdinov V R , Mikhaylichenko A F , Piskunova A A , Samtsov A V , Ivanov A M , Imyanitov E N , KHAIRUTDINOV V R , MIKHAILICHENKO A F , PISKUNOVA A A , SAMTSOV A V , IVANOV A M , IMYANITOV YE N
Published: February 2022

The IL12B gene encodes protein р40 being a common subunit of interleukin-12 and interleukin-23 playing an important
part in the pathogenesis of psoriasis. The IL12B gene has polymorphism rs12188300, which can be associated with the
risk of psoriasis development. The goal of the study was to assess the distribution of alleles of polymorphism rs12188300
in psoriatic patients in the Northwestern region of Russia. Genotyping was carried out using the real-time allele-specific
polymerase chain reaction. An increased occurrence of a rare allele T in psoriatic patients as compared to healthy people
was observed (OR = 1.96, р = 0.0007). The occurrence of the rare allele T in patients with psoriatic arthritis was higher
than in the control group (OR = 3.49, р = 0.005). These results suggest that rs12188300 polymorphism of the IL12B gene
is a new genetic marker of psoriasis and psoriatic arthritis.
Sexual dysfunctions in men suffering from sexually transmitted infections
Authors: Rakhmatullina M R , Filon O F
Published: February 2022

The authors present the results of a clinical, laboratory and sex study of patients suffering from sexually transmitted diseases (STD) and sexual dysfunctions. Goal. To study clinical features and risk factors related to the development of sexual dysfunctions in men suffering from STDs. Materials and methods. The study involved 106 men suffering from STDs, who were subdivided into the principal (patients with sexual dysfunctions) and control (patients without any sexual dysfunctions) groups. All of the subjects underwent clinical, laboratory (identification of pathogens causing STDs as well as opportunistic microorganisms) and instrumental (transrectal ultrasonic examination of the prostate) examinations. The sex study was conducted using the male sexual formula (MSF) quantification scale and Marriage Satisfaction questionnaire prepared by V.B. Stolin, T.L. Romanov and G.T. Butenko; sex constitution was assessed by using the Vector Scale for Determining the Male Sex Constitution. Results. The study revealed that both men suffering from STDs and men suffering from urogenital diseases caused by opportunistic microbial flora can develop sexual dysfunctions. A reliable difference in the structure of sexual pathologies in the subjects was established: predomination of isolated sexual dysfunctions in primary patients with sexual dysfunctions and prevalence of concomitant disorders in patients with sexual dysfunctions in the past medical history. Neurohumoral premorbidity (weak and weakened sex constitution) and disharmonious relations between sex partners were proved to be the key reasons of sexual disorders in patients with STDs. Conclusion. The established reasons and particular features of sexual disorders in patients with STDs need to be taken into consideration when examining patients for the purposes of early diagnostics and prevention of these disorders as well as for referring the patients to sexologist and/or psychotherapist on a timely basis.
Skin leiomyoma — clinical observation
Authors: Sheklakova M N , Kappusheva I A , Katunina O R , Butareva M M , Samarova N V , Nefedova M A
Published: February 2022

The authors describe a clinical observation of quite a rare neoplasm such as back skin leiomyoma in a female patient aged 56. They describe the clinical picture, differential diagnostics and pathohistological picture of the disease. The pain syndrome was arrested due to the treatment with calcium channel blockers in a combination with alpha-blockers.
Results of a study of genetic factors predisposing to the development of psoriasis among the population of the Russian Federation
Authors: MINEYEVA A A , KOZHUSHNAYA O S , ZNAMENSKAYA L F , CHIKIN V V , FRIGO N V
Published: February 2022

Goal. To assess the incidence of genes predisposing to the development of psoriasis based on selected molecular and genetic study methods among the Russian population. Materials and methods. By using allele specific hybridization methods in the form of real-time PCR and RFLP assay (Restriction Fragment Length Polymorphism), single-nucleotide polymorphisms of fragments of 13 genes associated with predisposition to the development of psoriasis were studied in whole blood samples obtained from 45 psoriatic patients: rs4649203 (gene IL-28RA), rs11209026 (gene IL-23R), rs610604 (gene TNFAIP3), rs514315 (gene SERPINB8), rs9304742 (gene ZNF816A), rs17728338 (gene TNIP1), rs13190932 (gene TRAF3IP2), rs2235617 (gene ZNF313), rs27524 (gene ERAP1), rs702873 (gene REL), rs3213094 (gene IL-12B), rs12720356 (gene TYK2), and rs8016947 (gene NFKBI). Results. A set of data on the genotype structure and incidence in respective loci of 13 genes associated with predisposition to develop psoriasis was obtained for the first time based on a Russian sample of patients. At this stage of the study, we failed to reveal any reliable differences concerning the incidence of individual genotypes between psoriatic patients and healthy people because of the small size of the sample. Gene TYK2 (rs1272035) served as an exclusion. The homozygous T/T genotype was revealed more often (p < 0.01) in psoriatic patients (95.6%) vs. healthy people (77.8%), which makes it possible to consider the carriers of this genotype as people predisposed to the development of psoriasis.
Current methods for preventing the development of cervical cancer in patients with papilloma viral infection
Authors: RAKHMATULINA M R , KITSAK V YA , BOLSHENKO N V
Published: February 2022

The article presents the results of recent studies of the role of human papillomavirus in potentiating cancer in the cervix. the authors describe methods for organizing efforts aimed at early diagnostics of cancer pathologies associated with papilloma viral infection. they describe aspects of the prevention of cervical cancer in Russia and abroad. they also disclose current screening strategies related to cancer pathologies of the cervix based on a combination of diagnostics methods.
Current concepts of genetic variability of genital mycoplasmas and their role in the development of inflammatory diseases of the urogenital system
Authors: Rakhmatullina M R , Kirichenko S V
Published: February 2022

The authors disclose current concepts of the taxonomic and morphologic characteristics of genital mycoplasmas and their role in the development of inflammatory urogenital diseases and reproductive disorders. They also discuss such issues as genetic variability of genital mycoplasmas and possible interrelation with different variants of the clinical course of inflammatory processes in the urogenital tract.
Immunohistochemistry detection of kappa-opioid receptors in human skin
Authors: Bobko S I , Lotts T , Metze D , Lvov A N , Staender S
Published: February 2022

The imbalance of p- and kappa-opioid receptors in the skin or central nervous system is currently deemed to be one of the reasons of chronic pruritus. A number of studies demonstrated a positive effect of system agonists of kappa-opioid receptors in the treatment of uremic pruritus, nodular pruritus, paraneoplastic and cholestatic pruritus. This research demonstrates an expression of kappa-opioid receptors in human skin (basal keratinocytes, dendritic cells, epidermal melanocytes and fibroblasts of the upper dermis) detected with the use of different immunochemistry methods.
Erythrokeratodermia variabilis (Mendes da Costa type). A case study
Authors: LVOV A N , ZNAMENSKAYA L F , MATUSHEVSKAYA YU I , VAKHITOVA I I
Published: February 2022

The article describes a clinical observation of a female patient who has suffered from Erythrokeratodermia variabilis (Mendes da Costa type) since the early childhood. It presents data on the pathogenesis, clinical forms and applied treatment methods.
Melanocytic nevi in psoriasis patients: results of a study with the use of dermatoscopy
Authors: Sergeyeva I G , Krinitsyna Yu M , Onipchenko V V , Makarova N G
Published: February 2022

According to the results of a study that involved 32 psoriatic patients, nevi with the diameter exceeding 5 mm are found in 68.8% of patients including 36% of patients with iatrogenic melanoma development risk factors (treatment with methotrexate and phototherapy), 50% of patients with anamnestic (burn injuries including vesication at the age below 18) and 4.5% of patients with inherited risk factors (melanoma in their relatives). As many as 32.4% of the nevi met the dysplastic nevi criteria in the course of the Pehamberger model analysis.
Pathogenic value of neuropeptides and growth factor proteins for the development of inflammation and itching in patients with prevalent dermatoses
Authors: CHIKIN V V , ROTANOV S V , KHAIRULLIN R F , ZNAMENSKAYA L F , VAKHITOVA I I , INOYATOVA L A
Published: February 2022

Goal. To determine the value of neuropeptides and growth factor proteins for the development of inflammation and itching in patients with atopic dermatitis and psoriasis. Materials and methods. There was a study of 13 patients with atopic dermatitis, 28 patients with psoriasis and eleven healthy volunteers. The severity and prevalence of the skin lesion in patients with atopic dermatitis was compared using the SCORAD score, and in psoriatic patients — using the PASI index. The extent of itching was assessed using a visual analog scale. The level of neuropeptides in blood serum of the subjects was determined using the enzyme-linked immunoelectrodiffusion assay: substance P and calcitonin gene-related peptide as well as nerve growth factor, amphiregulin, an epidermal growth factor, and semaphorin 3A, a nerve repulsion factor. Results. A statistically significant increase in the level of nerve growth factors in blood serum of patients with atopic dermatitis was observed (91.37 ± 16.39 pg/mL) vs. the control group (10.68 ± 8.37 pg/mL) (p < 0.05) as well as increased level of amphiregulin (46.09 ± 5.22 pg/mL) vs. the control group (10.21 ± 2.10) (p < 0.05). A positive correlation between the level of the nerve growth factor and SCORAD score was revealed. Conclusion. The results obtained confirm that nerve growth factors and amphiregulin are involved in the pathogenesis of atopic dermatitis.
Langerhans cell histiocytosis (histiocytosis x): a case study
Authors: Gorlanov I A , Zaslavsky D V , Mineyeva O K , Leina L M , Milyavskaya I R , Peredereyev S S , Bolshakova Ye S
Published: February 2022

The authors provide a case study of Langerhans cell histiocytosis (histiocytosis X) in a two-year-old girl. They describe major stages of the etiology and pathogenesis as well as clinical forms of the disease. Langerhans cell histiocytosis (histiocytosis X) is a rare disease characterized by lesions of the skin and internal organs.
The experience of treatment of patients suffering from medium and severe acne with the use of isotretinoin
Authors: Kungurov N V , Kokhan M M , Shabardina O V
Published: February 2022

Ural Research Institute of Dermatovenerology and Immunopathology, Ekaterinburg, Russia Shherbakova street 8, 620076, Ekaterinburg, Russia Objective: assessment of the clinical efficacy and safety of the treatment of patients suffering from acne of different forms of severity with the use of isotretinoin (Acnecutan). Materials and methods. Thirty-two patients with acne underwent treatment and made up 3 groups: 11 patients with the moderate to severe form of acne, 12 patients with the severe form of acne, and 9 patients with acne conglobata. The Basic Acne Severity Index (BASI) was used to assess objective manifestations of the disease. Results: As a result of treatment, the BASI reduced in patients with moderate to severe acne from 25.1 ± 1.6 to 1.5 ± 0.7, in patients with severe acne - from 31.5 ± 2.0 to 1.3 ± 0.8, with acne conglobata - from 45.3 ± 5.2 to 2.8 ± 0.7. Adverse effects that were recorded (such as skin dryness and xerosis, cheilitis and retinoid dermatitis, increased ASAT and ALAT levels in the blood serum) were eliminated with the use of skin care products or by reducing the drug dose. Conclusion: The authors demonstrated high efficacy and safety of Acnecutan in the treatment of patients suffering from acne vulgaris.