bluuebunny/crossref_metadata_2025 huggingface dataset:
Gümüş Nanopartiküllerin Morfolojisinin Protein Etkileşimleri Üzerindeki Etkisi
Authors: TOMAK Aysel , ÖKSEL KARAKUŞ Ceyda
Published: January 2024

Nanoteknolojideki gelişmelere paralel olarak biyomedikal uygulamalarda kullanılan nanopartiküllerin sayısında hızlı bir artış yaşanmıştır. Gümüş nanopartiküller, farklı metalik nanopartikül grupları arasında başta antibakteriyel etkinlik olmak üzere tıbbi uygulamaların gereksinimleriyle örtüşen çeşitli avantajlara sahip olmalari dolayısıyla öne çıkmakta ve yaygın olarak kullanılmaktadır. Gümüş nanopartikülleri avantajlı kılan yapı ve yüzey özellikleri biyolojik ortam etkileşimleri sonucunda değişiklik gösterebilmekte ve bu değişimler dolayısıyla biyolojik aktivite ve foksiyonellik gibi nanopartikül özellikleri de doğrudan etkilenmektedir. Nanopartiküllerin biyolojik ortamlarda değişen yüzey özelliklerinin en büyük nedeninin yüzeylerine tutunan proteinler olduğu bilinmektedir. Ancak nanopartiküllerin morfolojik özelliklerinin etraflarında oluşan bu protein halkasının bileşimine ve miktarına olan etkisi tam olarak aydınlatılmamıştır. Bu çalışmada, partikül morfolojisinin nanopartikül-protein etkileşimleri üzerine etkisi incelenmiştir. Bu amaçla küresel ve prizma-benzeri yapıya sahip gümüş nanopartikülleri detaylı olarak karakterize edilmiş ve yüzeylerine tutunan proteinler sodyum dodesil sülfat–poliakrilamid jel elektroforezi (SDS–PAGE) yöntemiyle analitik olarak tayin edilmiştir. Spesifik olarak, küresel ve prizmatik morfolojiye sahip gümüş nanopartikülleri protein eklentili hücre kültürü ortamı içerisinde farklı süre (15 dk, 2 sa ve 24 sa) ve sıcaklıklarda (22 oC ve 37 oC) inkübe edilmiş ve yüzeylerine tutunan proteinler tür ve miktar açısından karşılaştırılmıştır.
Cyber Security for IEEE 802.1 Time Sensitive In-Vehicle Networking: Recent Advances and Impact Analysis of DoS Attacks
Authors: TOPSAKAL Mustafa , CEVHER Selçuk
Published: January 2024

Dedicated computers control the operation of Cyber Physical Systems such as in-vehicle architectures with the help of sensors and actuators. Securing the real-time communication technologies for in-vehicle platforms attracts the attention of the research community. IEEE 802.1 Time Sensitive Networking (TSN) task group targets the standardization of Ethernet-based deterministic communication technologies due to its high bandwidth and low cost. IEEE P802.1DG working group specifies the profile for secure and real-time automotive embedded systems relying on TSN, which is envisioned to be widely used in future in-vehicle platforms. In this paper, we present an elaborate review of the research work on the security of in-vehicle communication networks with TSN support, and define various Denial of Service (DoS) attack scenarios targeting the real-time traffic in in-vehicle networks. We evaluate the impact of our attack scenarios on the performance of two different realistic in-vehicle communication networks with varying sizes. Experimental results show that DoS attacks can lead to severe consequences disrupting the healthy operation of safety-critical functions in a TSN-compliant in-vehicle network.
Maker Days for Kids
Authors: Grandl Maria , Bunke-Emden Hannah , Dietsch Danilo , Ebner Martin , Narr Kristin , Schaffert Anna , Schön Sandra
Published: January 2024

Als «Maker Days for kids» werden offene (digitale) Werkstätten für Kinder und Jugendliche von 8 bis 14 Jahren bezeichnet, die von einem Netzwerk rund um den Verein BIMS e. V. temporär aufgebaut und für mehrere Tage geöffnet und betreut werden. Die ersten Maker Days fanden im Jahr 2015 in Bad Reichenhall (Deutschland) statt. Seit 2018 gab es (bis dato) insgesamt vierzehn weitere Durchführungen in Graz (Österreich), Leipzig, Görlitz und Traunstein (alle in Deutschland). Das Netzwerk steht im engen Austausch im Hinblick auf Zielsetzung, Inhalte, didaktisch-pädagogische Vorgehensweise und Organisation. Obwohl sich die Verantwortlichen an den gleichen Prinzipien orientieren, gibt es doch mehrere Varianten der Durchführung – nicht zuletzt auch aufgrund von Herausforderungen, ausgelöst durch die Corona-Pandemie. Dieser Praxisbeitrag beschreibt die Merkmale und Prinzipien des Konzepts und stellt vergleichend dar, wie bei der Umsetzung des Konzepts vorgegangen wurde. Ziel dieses Beitrags ist es, erstmals einen Überblick über die durchgeführten Varianten der Maker Days for kids zu geben und die Hintergründe, Besonderheiten und Erkenntnisse der einzelnen Veranstaltungen aus Praxissicht zu beleuchten.
Effect of solvent polarity of phytochemical analysis of different Moroccan sites of Opuntia ficus-indica (L.) Mill. pads
Authors: RAZZAK Sara , AOUJI Marouane , SABRI Chaima , BENCHEHIDA Hiba , TAIBI Mariame , TABOZ Youness
Published: January 2024

The current study focuses on the study of phenolic compounds in methanol, dichloromethane, and chloroform extracts as solvents with increasing polarity, in order to quantify the secondary metabolites of Opuntia ficus indica pads collected from three Moroccan sites (Oulad Boubker, Imzouren, and Skoura). The findings showthat betalains and carotenoids were present, in varying amounts depending on the study area. The methanolic extracts had the concentrations of compounds. When analyzing the chemical composition using Gas Chromatography-Mass Spectrometry, it was found that linoleic acid was the unsaturated fatty acid accounting for 14.279%. Palmitic acid, fatty acid derivatives and alkanes were also detected in all regions. Among the extracts Imzouren had the concentration of fatty acids (24.874%) followed by Oulad Boubker (13.907%) and Skoura (13.319%). However, oleic acid was detected only in the extract of Skoura. Hence, we were able to confirm that the chemical differences among the various Opuntia extracts were primarily influenced by the selection of the extracting solvent and the prevailing climatic and geographical factors.
Habitar la concha
Authors: Marín Escobar Paloma , Murillo Lopera Isabel
Published: January 2024

Selección de poemas
Çalışanların Örgütsel Bağlılık İle Örgütsel Özdeşleşme Davranışının Yeşil Örgütsel Davranış Üzerindeki Etkisinde Çevre Tutkusunun Aracı Rolü
Authors: REŞAT CİCA Habibe , KARABULUT Tuğba
Published: January 2024

Bu çalışmanın amacı, çalışanların örgütsel bağlılık ile örgütsel özdeşleşme davranışının yeşil örgütsel davranış üzerindeki etkisinde çevre tutkusunun aracı rolünü araştırmaktır. Çalışmadaki araştırmanın örneklemi İstanbul’da Çevre Yönetim Belgesine (ISO 14001) sahip üç kamu kurumunda görev yapan 780 kişidir. Katılımcılardan demografik sorular, örgütsel bağlılık, örgütsel özdeşleşme, çevre tutkusu ve yeşil örgütsel davranış ölçeklerini içeren anket soruları ile veriler toplanmıştır. Verilerin analizleri SPSS 24, AMOS 24 ve PROCESS programları ile gerçekleştirilmiştir. Araştırmada yargısal örnekleme yöntemi uygulanmıştır. Değişkenler arasındaki ilişkileri ve aracılık rolünü incelemek için Yapısal Eşitlik Modellemesi kullanılmıştır. Araştırma sonucunda, örgütsel bağlılığın yeşil örgütsel davranış üzerinde anlamlı etkiye sahip olduğu, örgütsel bağlılığın çalışanların çevre tutkusu üzerinde anlamlı etkiye sahip olduğu, çalışanların çevre tutkusunun yeşil örgütsel davranış üzerindeki anlamlı etkisinin bulunduğu, örgütsel özdeşleşmenin yeşil örgütsel davranış üzerinde anlamlı etkiye sahip olduğu, örgütsel özdeşleşmenin çalışanların çevre tutkusu üzerinde anlamlı etkiye sahip olduğu tespit edilmiştir. Ayrıca örgütsel bağlılığın yeşil örgütsel davranış üzerindeki etkisinde çalışanların çevre tutkusunun kısmi aracı rolünün, örgütsel özdeşleşmenin yeşil örgütsel davranış üzerindeki etkisinde çalışanların çevre tutkusunun tam aracı etkisinin bulunduğu sonucuna ulaşılmıştır. Bu çalışma, örgütsel davranış literatüründe yeni olan yeşil örgütsel davranış kavramının ele alındığı az sayıdaki çalışmalardan birisi olduğu için bulgularının çevresel sürdürülebilirlik ve yeşil örgüt kavramlarını inceleyen literatüre özgün katkıda bulunacağı düşünülmektedir.
Covıd-19 Döneminde Sosyal Devlet Harcamaları: Milli Bir Model Önerisi
Authors: KAYA Zekayi
Published: January 2024

2007 Küresel Krizi ve sonrasında Covid-19 döneminde devletlerin harcamalarının ve dolayısıyla ekonomide rolünün arttığı görülmüştür. Maliye politikası araçlarına ve özellikle sosyal devlet harcamalarını oluşturan harcama kalemlerine ekonomideki dengesizliklerin ve istikrarsızlıkların giderilmesinde son dönemde daha yoğun olarak başvurulmuştur. Küresel kriz döneminde ve çalışmanın kapsamını oluşturan Covid-19 döneminde talep ve arzı etkileyen olumsuzlukların aşılması için devletler sosyal devlet harcamalarını artırarak ekonomiye müdahale etmişlerdir. Sosyal devlet harcamalarının artırılması ekonomide talep yetersizliği ve arz tıkanıklığı sorunlarının çözümünde etkili olmuştur. Covid-19 dönemi ve diğer dönemlerde ekonomide yaşanılan istikrarsızlık sorunları devletlerin düzenleyici ve destekleyici gücünün sürekli bir şekilde olması gerektiğini göstermektedir. Bu büyümenin ve istihdamın sürekliliği için gereklidir. Devletler sosyal devlet harcamaları vasıtasıyla ekonomide tüketici ve üreticiyi destekleyici harcamalar yapmalıdır. Bu çalışmada Covid-19 dönemini oluşturan 2020-2021 yıllarında yapılan sosyal devlet harcamaları diğer yıllar göz önünde tutularak ve Covid-19’un etkili olduğu bazı ülkeler bazında incelenmiştir. Bu dönemde sosyal devlet harcaması olarak; sosyal koruma harcamaları, işsizlik sigortası, kısa çalışma uygulamaları, ihtiyaç sahiplerine yapılan sosyal yardım harcamaları, sağlık harcamaları, evrensel temel gelir, vatandaşlık geliri (maaşı) uygulamaları gibi harcamaların değişik ülkelerce uygulamaya koyulduğu görülmüştür. Çalışmada, sosyal devlet harcamaları kapsamında, her ülke için sürdürülebilir büyüme ve istihdamı sağlayacak her durumda uygulanabilir millî bir model önerisi yapılmıştır.
Further Thoughts and Observations About Silent Arguments in Turkish
Authors: KORNFİLT Jaklin
Published: January 2024

The question of how silence is interpreted by native speakers, as well as when silence is possible to begin with, is one of the most basic issues with respect to the syntactic (and morpho-syntactic) investigations cross-linguistically. In these brief remarks, I would like to address some data in Turkish and their analysis to be found in this context in prior studies. More specifically, I would like to suggest that some of the claims made in the (scarce) literature on empty pronouns versus ellipsis in Turkish should be weakened somewhat, given that the generalizations proposed can be overridden in some contexts.
N. V. Gogol'ün "Ölü Canlar" Poemasında Yol Kronotopu
Authors: ŞENEL Melda
Published: January 2024

19. yüzyıl Rus edebiyatının ve eleştirel gerçekçiliğin en önde gelen temsilcilerinden olan Nikolay Vasilyeviç Gogol (1809-1852); trajik, gülünç, fantastik, grotesk tüm unsurları hiciv sanatıyla birleştirerek muazzam öyküler ve tiyatro yapıtları kaleme almıştır. Bir hiciv ustası olarak; devlet kurumları, bürokratları, toprak beyleri, serfleri ve tüm sınıftan insanlarıyla I.Nikolay dönemi Rusya’sını ağır bir eleştiriye tâbi tutmuş; yapıtlarıyla Rus halkını kendi gerçekliğiyle yüzleştirmek, ona yol göstermek ve onu bu yozlaşmışlıktan kurtarmak istemiştir. Bu bağlamda, konusunu Aleksandr Sergeyeviç Puşkin’in verdiği, gerçekte yaşanmış bir dolandırıcılık hikâyesine dayanan ve Gogol’ün poema olarak adlandırdığı, 1842 yılında yayımlanan Ölü Canlar romanı, Gogol’ün Rusya ile birlikte, ona karşı görevini yerine getirerek, âdeta kendi ruhunu da kurtarmak istediği bir yapıt olarak sanatının zirvesini oluşturmuştur. İlk yayımlandığında “Çiçikov’un Maceraları, ya da Ölü Canlar” başlığıyla okura sunulan roman, büyük oranda pikaresk özellikler taşımaktadır. Başkahraman Pavel İvanoviç Çiçikov romanın başından sonuna kadar yolda görülür; tüm olaylar, Çiçikov’un Rusya’da yaptığı yolculuklarla birbirine eklemlenerek romanın bütününü oluşturur. Rus edebiyat teorisyeni Mihail Bahtin’in zaman-uzam birlikteliği olarak edebiyat teorisine kazandırdığı kronotop kavramıyla ve bu bağlamda yol kronotopu temelinde yapıtın incelenmesinin sebebi; bu kronotopun zaman-uzam birlikteliğiyle, romanın türünden olay örgüsü oluşturmaya, roman karakterlerinin analizinden, yapıtın değerler bütünüyle okura vermek istediği mesaja kadar romanın temel bileşenleriyle analiz edilmesine olanak tanıması ve bu bağlamda yol kronotopu’nun yapıttaki önemini ortaya koymaktır. Çiçikov romanda farklı toprak sahiplerine yaptığı yolculuklarla yoldadır; ancak yazar, kahramanının metaforik olarak doğru yolu bulup bulamayacağı sorusuyla da okuru yüzleştirir. Yol artık sadece Çiçikov’un değildir; tüm Rusya’nın yoluna, yazarın da yaşam yoluna dönüşmüştür.
Sodium Glyceroxide: An Efficient Homogeneous Alkaline Catalyst for Biodiesel Synthesis
Authors: Santos Samuel , Braun João , Espíndola Guilherme , da Silva Josué , Renner Rodrigo , Fontoura Luiz
Published: January 2024

Biodiesel is obtained from the alcoholysis of triglycerides and has been used as a renewable alternative to diesel. Though the methanolysis of triglycerides in the presence of MeONa catalyst has been widely used, searching for alternatives that may improve the competitiveness of the production chain is still a challenge. The aim of this work was to evaluate sodium glyceroxide as a catalyst in the methanolysis of soy oil. Sodium glyceroxide was obtained from glycerol and NaOH in ethanol, and characterized by thermogravimetric analysis (TGA), X-ray powder diffraction (XRD) and, Fourier transform infrared (FTIR) spectroscopy. The transesterification reaction was optimized after two sets of experiments based on the Doehlert matrix experimental design. In the first one, the influence of the molar ratio of methanol/triglyceride, and the amount of catalyst (m/m with respect to the triglyceride) were studied. In the second set, the temperature, and the reaction time were studied. The best conditions were found as 12:1 molar ratio, 2% of catalyst, 50 ºC, and 60 min. The conditions were applied in the transesterification of canola and sunflower oils, and tallow. All the biodiesels were obtained with an ester content superior to 98%, free from methanol and triglycerides. Specific mass, viscosity, and pour point were determined and met the international specifications.
Estimación mensual de la biomasa, reclutamiento y mortalidad por pesca de la Anchoveta (Engraulis ringens) de la zona Norte de Chile en el período 1986-1989
Authors: Cubillos Luis
Published: January 2024

Se estima mensualmente la biomasa, el reclutamiento y la mortalidad por pesca de la anchoveta (Engraulis ringens) de la zona norte de Chile (18o21'S-24°00'S), en el período 1986-1989, mediante el Análisis de Población Virtual estructurado para datos de frecuencia de longitud. La serie de tiempo del reclutamiento considera a peces de 7,25 cm de longitud total, aproximadamente de 7 meses de edad. Las relaciones de stock-reclutamiento del tipo Ricker ajustadas, señalan un fuerte efecto denso-dependiente. Además, se demuestra el impacto sobre el reclutamiento del evento El Niño de 1987.
Ciclo reproductivo de Calyptraea (TROCHITA) trochiformis (GASTROPODA: CALYPTRAEIDAE) en bahía La Herradura , Coquimbo, Chile, utilizando un índice de producción de cápsulas ovígeras.
Authors: Cañete Juan I. , Illanes Juan E. , Ambler Rattcliff P.
Published: January 2024

Se describe el ciclo reproductivo anual de una población submareal del gastrópodo incubador Calyptraea (Trochita) trochiformis (Bom, 1778) a través de un índice de producción de cápsulas ovígeras, calculado como el cuociente entre el número de cápsulas ovígeras con estados embrionarios tempranos (huevos a trocófora) y la longitud de la concha de la hembra. Las muestras fueron recolectadas mensualmente entre febrero de 1989 y marzo de 1990 en Bahía La Herradura (29°58'55" S, 71°22'20" O), Coquimbo, Chile. Se detectó producción continua de cápsulas ovígeras durante todo el año. El valor del índice de producción de ovicápsulas fluctuó entre 0.68 -1.01 cápsulas mm1, siendo menor durante los meses de verano (< 0.88 cápsulas mm '). Se encontró una relación lineal positiva entre la longitud de la concha de la hembra (LO y el número de cápsulas ovígeras (NC):NC = 3,28 + 0,79 LC. La longitud de la hembra de menor tamaño con presencia de cápsulas fue 28 mm. El bajo valor del índice reproductivo durante el verano se debería a efectos negativos producidos por el incremento de la temperatura del agua de mar, canalización de energía hacia el crecimiento corporal en detrimento de la reproducción y una disminuciónde la concentración deoxígenodisueltoen el agua de mar por la intrusión de masas de aguas originadas por las surgencias.
Aspectos teóricos para el análisis de datos de captura y esfuerzo de pesca mediante modelos de función de transferencia.
Authors: Cubillos Luis , Sobarzo Pamela
Published: January 2024

La evaluación de recursos pesqueros a menudo se realiza a través de la relación entre las capturas o captura por unidad de esfuerzo y los esfuerzos de pesca anuales. Esta relación se utiliza para establecer niveles adecuados con el objeto de asegurar la conservación del recurso y por ende la explotación pesquera. Dado que las capturas, captura por unidad de esfuerzo, y esfuerzo de pesca son series de tiempo, en este trabajo se presentan aspectos teóricos para analizar mediante modelos de función de transferencia las relaciones entre estas variables, tomando en cuenta la estructura de autocorrelación de las series. Se demuestra la equivalencia entre la aproximación propuesta y los modelos clásicos de producción históricamente utilizados en el análisis de pesquerías, y se incorpora a éstos la estructura correlacionada del error en forma sistemática. Finalmente, se discute sobre la potencial aplicación de los modelos de función de transferencia en la investigación de pesquerías.
Ciclo reproductivo del Lenguado de Ojos Chicos, Paralichthys microps (GÜNTHER, 1881) (PLEURONECTIFORMES, PARALICHTHYDAE) frente al litoral de Concepción, Chile.
Authors: Chong Javier , González Paola
Published: January 2024

Se efectuó un estudio del ciclo reproductivo del lenguado de ojos chicos, Paralichthys microps (Günther, 1881), sobre la base de 366 ejemplares capturados frente al litoral de Concepción, Chile, entre octubre de 1992 y marzo de 1994. El examen macroscópico de las gónadas mostró la presencia de hembras sexualmente maduras durante todo el período de estudio, en cambio, en los machos se detectó tanto especímenes inmaduros como en maduración. El índice gonadosomático en las hembras presentó valores altos a lo largo de todo el período, confirmando un extenso lapso de actividad gonádica. El análisis histológico reveló la presencia simultánea de ovocitos en diferentes estados de desarrollo a través de los meses, a lo cual se agrega una época reproductiva principal en primavera y verano con desoves de menor intensidad en otoño e invierno, lo que señala para P. microps una modalidad de desove múltiple o fraccionado.
In Silico Immunogenicity Assessment of Therapeutic Peptides
Authors: Li Wenzhen , Wei Jinyi , Jiang Qianhu , Zhou Yuwei , Yan Xingru , Xiang Changcheng , Huang Jian
Published: January 2024

The application of therapeutic peptides in clinical practice has significantly
progressed in the past decades. However, immunogenicity remains an inevitable and crucial
issue in the development of therapeutic peptides. The prediction of antigenic peptides
presented by MHC class II is a critical approach to evaluating the immunogenicity
of therapeutic peptides. With the continuous upgrade of algorithms and databases in recent
years, the prediction accuracy has been significantly improved. This has made in silico
evaluation an important component of immunogenicity assessment in therapeutic
peptide development. In this review, we summarize the development of peptide-MHC-II
binding prediction methods for antigenic peptides presented by MHC class II molecules
and provide a systematic explanation of the most advanced ones, aiming to deepen our
understanding of this field that requires particular attention.
Recent Advancement in Inhaled Nano-drug Delivery for Pulmonary, Nasal, and Nose-to-brain Diseases
Authors: Fu Qiuxia , Liu Yangjie , Peng Cao , Muluh Tobias Achu , Anayyat Umer , Liang Liu
Published: January 2024

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Pulmonary, nasal, and nose-to-brain diseases involve clinical approaches, such as bronchodilators,
inhaled steroids, oxygen therapy, antibiotics, antihistamines, nasal steroids, decongestants,
intranasal drug delivery, neurostimulation, and surgery to treat patients. However, systemic
medicines have serious adverse effects, necessitating the development of inhaled formulations that
allow precise drug delivery to the airways with minimum systemic drug exposure. Particle size, surface
charge, biocompatibility, drug capacity, and mucoadhesive are unique chemical and physical
features that must be considered for pulmonary and nasal delivery routes due to anatomical and permeability
considerations. The traditional management of numerous chronic diseases has a variety of
drawbacks. As a result, targeted medicine delivery systems that employ nanotechnology enhancer
drug efficiency and optimize the overall outcome are created. The pulmonary route is one of the
most essential targeted drug delivery systems because it allows the administering of drugs locally
and systemically to the lungs, nasal cavity, and brain. Furthermore, the lungs' beneficial characteristics,
such as their ability to inhibit first-pass metabolism and their thin epithelial layer, help treat
several health complications. The potential to serve as noninvasive self-administration delivery sites
of the lung and nasal routes is discussed in this script. New methods for treating respiratory and some
systemic diseases with inhalation have been explored and highlight particular attention to using specialized
nanocarriers for delivering various drugs via the nasal and pulmonary pathways. The design
and development of inhaled nanomedicine for pulmonary, nasal, and respiratory medicine applications
is a potential approach for clinical translation.
Bromodomain Protein-directed Agents and MYC in Small Cell Lung
Cancer
Authors: Hamilton Gerhard , Stickler Sandra , Rath Barbara
Published: January 2024

Small cell lung cancer (SCLC) has a dismal prognosis. In addition to the inactivation of
the tumor suppressors TP53 and RB1, tumor-promoting MYC and paralogs are frequently overexpressed
in this neuroendocrine carcinoma. SCLC exhibits high resistance to second-line chemotherapy
and all attempts of novel drugs and targeted therapy have failed so far to achieve superior
survival. MYC and paralogs have key roles in the oncogenic process, orchestrating proliferation,
apoptosis, differentiation, and metabolism. In SCLC, MYC-L and MYC regulate the neuroendocrine
dedifferentiation of SCLC cells from Type A (ASCL1 expression) to the other SCLC subtypes.
Targeting MYC to suppress tumor growth is difficult due to the lack of suitable binding
pockets and the most advanced miniprotein inhibitor Omomyc exhibits limited efficacy. MYC
may be targeted indirectly via the bromodomain (BET) protein BRD4, which activates MYC transcription,
by specific BET inhibitors that reduce the expression of this oncogenic driver. Here, novel
BET-directed Proteolysis Targeting Chimeras (PROTACs) are discussed that show high antiproliferative
activity in SCLC. Particularly, ARV-825, targeting specifically BRD4, exhibits superior
cytotoxic effects on SCLC cell lines and may become a valuable adjunct to SCLC combination
chemotherapy.
Targeted Mevalonate Pathway and Autophagy in Antitumor
Immunotherapy
Authors: Xing Zongrui , Jiang Xiangyan , Wu Yuxia , Yu Zeyuan
Published: January 2024

Tumors of the digestive system are currently one of the leading causes of cancer-related
death worldwide. Despite considerable progress in tumor immunotherapy, the prognosis for
most patients remains poor. In the tumor microenvironment (TME), tumor cells attain immune escape
through immune editing and acquire immune tolerance. The mevalonate pathway and autophagy
play important roles in cancer biology, antitumor immunity, and regulation of the TME.
In addition, there is metabolic crosstalk between the two pathways. However, their role in promoting
immune tolerance in digestive system tumors has not previously been summarized. Therefore,
this review focuses on the cancer biology of the mevalonate pathway and autophagy, the regulation
of the TME, metabolic crosstalk between the pathways, and the evaluation of their efficacy as
targeted inhibitors in clinical tumor immunotherapy.
Redox Imbalance and Cardiovascular Pathogenesis: Exploring the Therapeutic
Potential of Phytochemicals
Authors: Arandhara Arunabh , Saha Dipankar , Deka Dhruva Jyoti , Deka Mrinmoy , Kumar Das Bhrigu
Published: January 2024

The intriguing role of the oxidation system in cardiovascular disease lies in its contribution
to chronic and acute increases in intracellular reactive oxygen species (ROS), driving the
progression of cardiovascular diseases (CVDs). ROS, produced as by-products of oxidative physiological
and metabolic events, act as mediators in various signaling pathways contributing to
cardiovascular pathology. The delicate equilibrium between the production of free radicals and
antioxidant defense shifts in favor of the former, resulting in redox imbalance and extensive cellular
damage. Among CVDs, coronary artery disease (CAD) remains as the leading cause of
death globally. Understanding the significance of oxidative damage in the dysfunction of endothelial
cells, atherosclerosis, and other pathogenic events and pathways is crucial for preventing
and managing CVD. Consequently, it is imperative to comprehend the mechanism/s underlying
the pathogenic alterations of CVD due to oxidative damage to develop effective prevention strategies.
Many studies have reported bioactive phytochemical/s as potential therapies against CVDs,
modulating ROS generation, controlling the CVD-related inflammatory mediators and protecting
the vascular system. Therefore, this review provides an update for understanding how the phytoconstituents
exhibit preventive roles in oxidative stress-related CVD, thus improving the quality
of life of people. This study conducted a thorough literature search on CVD, oxidative imbalance,
and phytoconstituents. The search was performed using multiple search engines and the main
keywords, and only English publications until June 2023 were included. However, there is a need
for more research and clinical trials to fully elucidate the efficacy and safety of these phytochemicals
for managing the disease.
Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions
Authors: Mody Deepansh , Joshi Priyanka , Antil Monika , Gupta Rakesh K. , Gupta Vibha
Published: January 2024

:

Multidrug-resistant ESKAPE pathogens are the leading cause of hospital-acquired
infections across the globe, posing challenges for clinicians. Random genetic mutations and constant
exposure to antibiotics in healthcare settings result in strains resistant to commonly used
antibiotics, creating life-threatening conditions. If the magic of “antibiotics” is to be sustained, a
new class of antimicrobials against novel targets is urgently needed. This necessitates understanding
and identifying novel biochemical pathways and bacterial virulence factors that can be
targeted for therapeutic interventions. Keeping in view the unambiguous role of the kinome in
bacterial survival and virulence, this review provides a survey of effector bacterial kinases involved
in evading host immune responses and drug resistance. The formation of biofilms is a
critical feature associated with the pathogenesis and survival of ESKAPE organisms in the hostile
host milieu. Hence, kinases involved in the biofilm pathway are also elucidated for clinical
relevance. In addition, endeavors in the development of therapeutics against ESKAPE kinases
are also summarized to provide direction to researchers pursuing the field.
Biological Potential and Therapeutic Effectiveness of Artemetin from
Traditional to Modern Medicine: An Update on Pharmacological
Activities and Analytical Aspects
Authors: Patel Kanika , Patel Dinesh Kumar
Published: January 2024

Background::

Background: Plant products derived from natural sources have been used in
medicine as a raw material and newer kinds of drug molecules in pharmaceuticals and other
allied health sectors. Phytochemicals have numerous medicinal potentials, including anti-
ageing, anti-carcinogenic, anti-microbial, anti-oxidant, and anti-inflammatory activity in
medicine. Development and biological application of herbal products in modern medicine
signified the value of traditional medicinal plants in health care systems.

Methods::

The objective of the present study was to explore the scientific knowledge of the
medicinal importance and therapeutic potential of artemetin in medicine. However, scientific
investigations for their pharmacological activities in medicine have been done through
scientific data analysis of different scientific research work collected from PubMed,
Google, Science Direct and Google Scholar in order to know the biological importance of
artemetin in medicine. Moreover, analytical data of artemetin have also been discussed in
the present work.

Results::

The present work scientific data signified the biological potential of artemetin in
medicine. Artemetin has been derived from numerous medicinal plants and dietary herbs,
including Artemisia absinthium, Artemisia argyi, Achillea millefolium, and Vitex trifolia.
Artemetin has anti-malarial, anti-oxidant, anti-apoptotic, anti-microbial, anti-tumoral, antiatherosclerotic,
anti-inflammatory, hypotensive and hepatoprotective effects. Further, the
biological role of artemetin on lipid oxidation, cytokine production, lipoxygenase, and estrogen-
like effects was also investigated in the present work. Analytical data on artemetin in the
present paper signified their important role in the isolation, separation, and identification of
different classes of pure phytochemicals, including artemetin in medicine.

Conclusion::

Scientific data analysis of artemetin signified its therapeutic potential in medicine
for the development of newer scientific approaches for different human disorders.
Terahertz Communication with MIMO-OFDM in FANETs for 6G
Authors: Mustari Nazifa , Karabulut Muhammet Ali , Shah A. F. M. Shahen , Tureli Ufuk
Published: January 2024

Background:

Unmanned aerial vehicles (UAVs) are envisioned in several intelligent transport system (ITS) application fields due to their autonomous operation, mobility, and communication/processing capabilities.

Methods:

In order to increase performance, dependability, and customer satisfaction, wireless communications are being used for essential and noncritical services in a variety of transportation systems. Terahertz (THz) communication aims to raise the wireless communication frequency band to the terahertz level and is one of the technologies that shows the most promise in addressing needs like the exponential increase in the number of devices, the necessity for higher data rates, and the need for larger channel capacity. For meeting the demands of 5G and 6G users, the hybrid combination of multiple input multiple output (MIMO) and orthogonal frequency division multiplexing (OFDM) appears to be an excellent technology. Therefore, it is essential to investigate the performance of THz communication with MIMO-OFDM in flying ad hoc networks (FANETs) for 6G. FANETs are multi-UAV systems arranged in an ad hoc way.

Results:

In this paper, the performance of the THz communication with MIMO-OFDM in FANETs for 6G is evaluated. The Markov chain model-based analytical study is used to derive how parameters and performance measures relate to one another.

Conclusion:

The equations for path loss, outage probability, bit error rate, and throughput are attained. Moreover, numerical results are shown to justify the outcomes of the analytical studies.
Islamic Epistemology in the Bangladesh Government System (1996–2022): An Analysis of Political Ideologies
Authors: Ruhullah Mohammad Eisa , Ushama Thameem
Published: January 2024

This study aims to explore the extent of Islamization in Bangladesh during the tenure of democratically elected leaders Sheikh Hasina and Khaleda Zia. The objective is to analyze the state of democratic governance in Bangladesh from a religious perspective, focusing specifically on Islamic political epistemology. It begins by defining Islamic Political Epistemology and its significance in acknowledging Islam’s role in democratic power. This qualitative descriptive analysis examines recent research papers from highly ranked resources such as Scopus. It is important to note that specific methods can strengthen strategies for enforcing electoral decrees, improve credentials for arbitration through sovereignty within the dominion branch, and increase national participation in political acts and society through Islamic Political Epistemology. Sheikh Hasina’s new regime has achieved significant progress in implementing Islamic development in bureaucracy and regulations. Qawmi Madrasah has contributed significantly to Islamic Education in Bangladesh, and the current government recognizes their educational certificates. The salaries of teachers and Imams at Government Madrasah-e-Alia have been increased, which is a significant policy change. The study revealed that Khaleda Zia’s government could have succeeded despite its alliance with Islamic political parties. Having a coalition with Islamic political parties does not necessarily mean that the country’s political ideology is institutionalized in an Islamic way. Opposite, Bangladesh’s government, with partial financing from Saudi Arabia, is constructing 560 mosques that will also serve as artistic centres to promote Islamic epistemology and combat extremism. However, this government operates under a one-party system with the Awami League party, led by Sheikh Hasina, idolizing Sheikh Mujibur Rahman.
Árelemzési gyakorlatok a sertéságazatok aspektusában
Authors: Marczin Tamás
Published: January 2024

The analysis of sales prices has become a particularly important topic in pig production research, including statistical analysis. With globalisation, we can say that today we are talking about a sector constantly exposed to the effects of the world market. It is also worth pointing out that, compared with other sectors, the impact of external regulation and influence is less pronounced. Thus, the aim of the present research was to identify the journal articles published on the subject of price analysis and, on the basis of these, to establish the correlation with the methodologies often used. It examines the spatial location of price analysis. The results obtained show that the practice of price analysis is mainly carried out in the context of market leading countries, usually on the basis of a cross product chain issue. The research shows the emergence in recent years of increasingly sophisticated methodologies that allow more accurate conclusions to be drawn, while also facilitating planning from a practical point of view.
Ways of Expressing the Gender Aspect in a Lyrical Text
Authors: Gromenko M. V.
Published: January 2024

The article attempts to describe and identify the linguistic means of expressing the gender aspect in the lyrics of V. M. Tushnova. This is due to the fact that the consideration of linguistic means of expressing the gender aspect in a lyrical work will allow not only to analyze the means of representation in the text, but also in speech. The analysis of language structures allows us to obtain information about the role gender plays in a particular culture, what behavioral norms for men and women are fixed in texts of different types, how the idea of gender norms, masculinity and femininity changes over time, what stylistic features can be attributed to predominantly female or predominantly male, how it is understood masculinity and femininity in different languages and cultures, how gender identity affects language acquisition, with which fragments and thematic areas of the linguistic picture of the world it is associated.

The research material is also relevant for the stylistics and hermeneutics of a literary text, as it allows us to see the ways of lexical development of the image of a man and a woman in a poetic text, to trace the emergence of associative meanings, to identify which male images are present in female poetry
Development of State Support Measures for Special Economic Zones to Ensure the Transition to Advanced Development of the Russian Federation
Authors: Bakharev K. I.
Published: January 2024

Relevance. In order to strengthen the economy and reduce dependence on imports under sanctions, the state is taking measures to support domestic producers whose activities are related to import substitution. In this regard, the creation, development and provision of state support measures to special economic zones will lead to the development of domestic production, which will contribute to the growth of the regional economy, create jobs, improve living standards and transition to advanced development.The purpose of the study is to assess the measures of state support for SEZ residents, to study the stages of their development, to develop recommendations for improving regulatory policy in this area. Substantiation of promising areas of SEZ operation based on the assessment of existing ones.Objectives: identify and characterize the types of SEZs in the Russian Federation; to identify the criteria for the creation of SEZs; to conduct an economic and statistical assessment of the results of their functioning; to substantiate recommendations for improving the state regulatory policy in this area.Methodology. In order to achieve the set research goals, the author used general scientific methods, generalization of scientific practice, economic and statistical analysis, synthesis, deduction, induction.Results. In the course of the study, the author reviewed the main state support measures provided by the state to SEZ residents, assessed tax benefits, analyzed the regulatory framework and criteria for the creation of SEZ in Russia.Conclusions. The main instrument of SEZ support is the provision of benefits to their residents. This advantage makes SEZs attractive platforms for entrepreneurs, which allows them to increase competitiveness, increase profits, create jobs and increase production volumes. The regulatory and legal framework of the SEZ continues to be improved and supplemented, including due to the growing practice of SEZ functioning in Russia. Statistics show that SEZs are developing and becoming effective levers for the development of the regional economy to ensure the transition to advanced development.
Da caridade à cidadania em fluxos
Authors: Silva Neto João Damasio da
Published: January 2024

Este trabalho analisa a circulação dos posicionamentos espíritas nas eleições presidenciais de 2018 no Brasil como indícios de uma transformação mais ampla na relação entre religião e política na sociedade em vias de midiatização. Historicamente, os espíritas se basearam no paradoxo entre laicidade e neutralidade para eleger a caridade como exercício político. O circuito-ambiente aqui analisado aponta para aberturas desse modelo na forma de uma cidadania em fluxos. Foram analisados três âmbitos (sócio-organizacional, técnico-midiático e político-discursivo) em que os posicionamentos espíritas operam: a) tentativas de neutralização política; b) expressão de motivações sociais espíritas; c) aberturas para estratégias mediadoras e d) aberturas para fluxos adiante e táticas coletivas progressistas, correspondendo às lógicas de midiatização.
Apresentação
Authors: Cervi Emerson Urizzi , Mendonça Ricardo Fabrino , Chagas Viktor
Published: January 2024

Editorial da Revista Compolítica, v. 10, n. 2, 2020.
"Construindo o amanhã"
Authors: Araujo Mayara , Oliveira Alana
Published: January 2024

O artigo discute a difusão do soft power japonês no século XXI, tomando como lócus de investigação a utilização da campanha Cool Japan no contexto das Olimpíadas de 2021. Percebe-se que na virada do século XX o Japão modificou suas estratégias de política externa, investindo na diplomacia cultural como um dos métodos para atingir seus objetivos. Através de uma discussão teórica realizada com o apoio de alguns materiais oficiais do evento, partimos da hipótese de que o Japão instrumentaliza o Cool Japan para promover seu soft power e criar uma imagem positiva do país internacionalmente, sustentando, assim, seu branding nacional baseado em prestígio e simpatia diante do cenário internacional.
política na bancada
Authors: Fernandes Carla Montuori , Oliveira Luiz Ademir de , Coimbra Mayra Regina , Gomes Vinícius Borges
Published: January 2024

Este artigo tem por objetivo analisar as entrevistas realizadas pelo Jornal Nacional com os cinco principais candidatos nas eleições presidenciais de 2018. Diante da posição marcante do telejornal em cenários eleitorais, o artigo traz a hipótese de que o JN, ao se utilizar das premissas da legitimidade jornalística, transforma as sabatinas em espaços de debate e confronto argumentativo. Exibida no horário nobre, as sabatinas ganharam enorme visibilidade, diante do tempo de exposição dos candidatos, que em algumas circunstâncias superaram o espaço do presidenciável no Horário Gratuito de Propaganda Eleitoral (HGPE). Para compreender como o telejornal conduziu as sabatinas, será utilizada metodologia da análise de conteúdo (Bardin, 2011).
mídia comercial e a legitimidade da mídia pública
Authors: Oliveira Gisele Pimenta de , Del Bianco Nelia Rodrigues
Published: January 2024

As rádios e TVs públicas esbarram em desafios institucionais, políticos, econômicos e culturais para alcançar posição de serviço legítimo e socialmente relevante. Partindo da premissa de que a mídia comercial difunde visões sobre determinados temas, este artigo mapeia os argumentos usados por jornais de referência ao abordarem o serviço público de radiodifusão. Metodologicamente, utiliza-se da análise de conteúdo para observar 36 editoriais, publicados entre 2007 e 2018 por Folha de S. Paulo, Estado de São Paulo e O Globo. De forma geral, nota-se que a mídia pública é apresentada por uma ótica predominantemente negativa, evidenciando que estão a serviço de uma comunicação oficial, partidária e propagandística.
crise do liberalismo estadunidense
Authors: Garcia da Silva Luiz Eduardo
Published: January 2024

Como foi possível a eleição de Donald Trump em 2016 e por que o campo progressista norte-americano não conseguiu fazer frente a sua ascensão? Essas são as perguntas que Mark Lilla em seu novo livro se propõe a responder. Observando a construção de uma cultura política cada vez mais centrada no individualismo, o autor critica a maneira como os agentes do campo liberal dos Estados Unidos cristalizaram um modo de fazer política caracterizado em pautas puramente identitárias que tornam incapaz a construção de uma agenda política compartilhada. Esta “pseudopolítica” faz com que as demandas dos progressistas sejam crescentemente refratárias gerando como consequência o enfraquecimento eleitoral do partido democrata e um vácuo político que é capaz de ser preenchido por figuras que saibam adaptar seu discurso à essa nova mentalidade antidemocrática.
Apresentação
Authors: Chagas Viktor , Mendonça Ricardo Fabrino , Cervi Emerson Urizzi
Published: January 2024

Editorial 2020.3.
Tanques e togas
Authors: Dutra Luma Poletti
Published: January 2024

O Supremo Tribunal Federal (STF) não se opôs ao golpe militar em 1964. Sua atuação durante a ditadura foi marcada por um misto de conivência e episódios de enfrentamento, manifestados principalmente por meio da concessão de habeas corpus a presos políticos. O livro do jornalista Felipe Recondo apresenta uma corte que possuía atribuições diferentes das de hoje. Uma instituição fechada, formada por ministros reservados, que atraía pouca atenção do público. Cenário oposto ao atual, em que o STF é alvo de protestos, ameaças, suas sessões são televisionadas e seus ministros concedem entrevistas e tecem comentários em redes sociais. A leitura revela, porém, alguns desafios que permanecem mesmo após a redemocratização, como a constante tentativa de interferência do poder Executivo.
A expansão da agenda deliberativa, poder e populismo (Entrevista com Nicole Curato)
Authors: Mendes Motta Filipe
Published: January 2024

Nicole Curato é professora associada no Centre for Deliberative Democracy and Global Governance, na Universidade de Camberra, na Austrália. Nos últimos anos, fez numerosas contribuições teóricas e empíricas para a pesquisa deliberativa, publicando os livros Power in Deliberative Democracy (2019, em coautoria com Marit Hammond e John Min) e Democracy in a Time of Misery (CURATO, 2019), uma extensa etnografia sobre como a vida pública foi reconstruída no sequência de um tufão mortal nas Filipinas. Nicole também tem colaborado para as discussões sobre populismo e democracia. Nesta conversa, Nicole discute os últimos avanços nos estudos sobre democracia deliberativa, incluindo a ampliação da diversidade de questões abordadas por esse campo de pesquisa, as relações entre poder e deliberação, a intensificação de experimentos deliberativos com minipúblicos e a importância de abordagens etnográficas para a pesquisa democrática.
As ações do (des)governo Bolsonaro contra a Empresa Brasil de Comunicação
Authors: Pinheiro Elton Bruno
Published: January 2024

O presente estudo dedica-se a refletir sobre aspectos contemporâneos – “ações sociais” / “comportamentos humanos” – que tensionam o processo de conformação do Serviço de Radiodifusão Pública brasileiro. Para tanto, parte de uma perspectiva teórica e metodológica alicerçada na Sociologia Compreensiva (Weber, 1995; 2012; 2014). O caso analisado está delimitado pelas ações da gestão Bolsonaro no âmbito da Empresa Brasil de Comunicação (EBC), focando, sobretudo, no seu plano de desestatização – e nas ameaças de extinção – da Empresa, o que se configura como uma ação inconstitucional, tendo em vista o que rege o Artigo nº 223 da Constituição Federal sobre a complementaridade entre os sistemas de radiodifusão público, estatal e privado. Como resultado, o estudo des(en)cobre como o governo Bolsonaro tem buscado deslegitimar a EBC a partir de ações voltadas a fins particulares (políticos/partidários), a valores / crenças / convicções (sobretudo ideológicos), a estados emocionais (relacionados a promessas de campanha e situações factuais) e à tradição (em contraposição ao “direito”).
visibilidade de atores sociais no noticiário político
Authors: Araújo Arthur
Published: January 2024

Esta pesquisa tem o objetivo de comparar a presença de atores políticos nos websites Folha de S. Paulo e Nexo Jornal, sendo um a amostra de um veículo de jornalismo tradicional e outro de jornalismo independente, e estudá-las de acordo com a lógica do campo jornalístico. Para isso, analisamos os elementos de abertura de 95 matérias da editoria de Poder na Folha de S. Paulo e da tag Política no Nexo Jornal. A metodologia utilizada é a Análise de Conteúdo (BARDIN, 1977; SAMPAIO, LYCARIÃO, 2021), com investigação quantitativa e qualitativa de citações e menções. Como resultados, temos que a categoria “independente” não é suficiente para assegurar a construção de uma esfera de visibilidade diferenciada; a linha editorial do Nexo garante número relevante de citações a fontes especializadas e atores internacionais e a organização das rotinas de trabalho, valores (interesse público), funções (fiscalização) e critérios de noticiabilidade (conflito e polêmica) influenciam no acesso dos atores ao noticiário