bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies
Authors: Chervin Adam S. , Stone Jennifer D. , Konieczna Iwona , Calabrese Kelly M. , Wang Ningyan , Haribhai Dipica , Dong Feng , White Michael K. , Rodriguez Luis E. , Bukofzer Gail T. , Ellis Paul A. , Cosgrove Cormac , Hecquet Claudie , Clarin Jerry D. , Palma Joann P. , Reilly Edward B.
Published: August 2023

Abstract
CD3 bispecific T-cell engagers (TCE), comprised of a tumor-targeting domain linked to a CD3 binding domain, function by bridging target-positive tumors and CD3-expressing effector T cells enabling redirected T cell–mediated killing of tumor cells. Although the majority of CD3 bispecific molecules in clinical development incorporate tumor-targeting antibody-based binding domains, many tumor-associated antigens derive from intracellular proteins and are not accessible to targeting via antibody. Intracellular proteins processed into short peptide fragments and presented on the cell surface by MHC proteins are recognized by T-cell receptors (TCR) on the surface of T cells. Here we describe the generation and preclinical evaluation of ABBV-184, a novel TCR/anti-CD3 bispecific composed of a highly selective soluble TCR that binds a peptide derived from the oncogene survivin (BIRC5) bound to the class I MHC allele human leukocyte antigen (HLA)-A*02:01 expressed on tumor cells, linked to a specific binder to the CD3 receptor on T cells. ABBV-184 drives an optimal distance between T cell and target cell thereby enabling sensitive recognition of low-density peptide/MHC targets. Consistent with the expression profile of survivin across a broad range of both hematologic and solid tumors, treatment of acute myeloid leukemia (AML) and non–small cell lung cancer (NSCLC) cell lines with ABBV-184 results in T-cell activation, proliferation, and potent redirected cytotoxicity of HLA-A2–positive target cell lines, both in vitro and in vivo, including patient-derived AML samples. These results indicate that ABBV-184 is an attractive clinical candidate for the treatment of patients with AML and NSCLC.
Data from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for treatment of Nectin-4-expressing Cancers
Authors: Zhou Wei , Fang Peng , Yu Dongan , Ren Hongyuan , You Meng , Yin Long , Mei Fei , Zhu Huikai , Wang Zhenzhen , Xu Hui , Cao Yuxia , Sun Xiaowei , Xu Xiaohong , Bi Jianjun , Wang Jin , Ma Lanping , Wang Xin , Chen Lin , Zhang Yongliang , Cen Xiaowei , Zhu Xi , Lou Liguang , Liu Datao , Tan Xiaoding , Yang Jinliang , Meng Tao , Shen Jingkang
Published: August 2023

Abstract
Overexpression of nectin cell adhesion protein 4 correlates with cancer progression and poor prognosis in many human malignancies. Enfortumab vedotin (EV) is the first nectin-4-targeting antibody drug conjugate approved by the US Food and Drug Administration for treatment of urothelial cancer. However, inadequate efficacy has limited progress in the treatment of other solid tumors with EV. Furthermore, ocular, pulmonary, and hematological toxic side effects are common in nectin-4-targeted therapy, which frequently results in dose reduction and/or treatment termination. Thus, we designed a second generation nectin-4-specific drug, 9MW2821, based on interchain-disulfide drug conjugate technology. This novel drug contained a site-specifically conjugated humanized antibody and the cytotoxic moiety monomethyl auristatin E. The homogenous drug-antibody ratio and novel linker chemistry of 9MW2821 increased the stability of conjugate in the systemic circulation, enabling highly efficient drug delivery and avoiding off-target toxicity. In preclinical evaluation, 9MW2821 exhibited nectin-4 specific cell binding, efficient internalization, bystander killing, and equivalent or superior antitumor activity compared with EV in both cell-line-derived xenograft and patient-derived xenograft models. In addition, 9MW2821 demonstrated a favorable safety profile; the highest non-severely toxic dose in monkey toxicological studies was 6 mg/kg, with milder adverse events compare to EV. Overall, 9MW2821 is a nectin-4-directed, investigational antibody-drug conjugate based on innovative technology that endowed the drug with compelling preclinical antitumor activity and a favorable therapeutic index. The 9MW2821 antibody-drug conjugate is being investigated in a Phase I/II clinical trial (NCT05216965) in patients with advanced solid tumors.
Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells
Authors: Hardin Haley M. , Dinh Christine T. , Huegel Julianne , Petrilli Alejandra M. , Bracho Olena , Allaf Abdulrahman M. , Karajannis Matthias A. , Griswold Anthony J. , Ivan Michael E. , Morcos Jacques , Gultekin Sakir H. , Telischi Fred F. , Liu Xue Zhong , Fernandez-Valle Cristina
Published: August 2023

Neurofibromatosis Type 2 (NF2) is a tumor predisposition syndrome caused by germline inactivating mutations in the NF2 gene encoding the merlin tumor suppressor. Patients develop multiple benign tumor types in the nervous system including bilateral vestibular schwannomas (VS). Standard treatments include surgery and radiation therapy, which may lead to loss of hearing, impaired facial nerve function, and other complications. Kinase inhibitor monotherapies have been evaluated clinically for NF2 patients with limited success, and more effective nonsurgical therapies are urgently needed. Schwannoma model cells treated with PI3K inhibitors upregulate activity of the focal adhesion kinase (FAK) family as a compensatory survival pathway. We screened combinations of 13 clinically relevant PI3K and FAK inhibitors using human isogenic normal and merlin-deficient Schwann cell lines. The most efficacious combination was PI3K/mTOR inhibitor omipalisib with SRC/FAK inhibitor dasatinib. Sub-GI50 doses of the single drugs blocked phosphorylation of their major target proteins. The combination was superior to either single agent in promoting a G1 cell-cycle arrest and produced a 44% decrease in tumor growth over a 2-week period in a pilot orthotopic allograft model. Evaluation of single and combination drugs in six human primary VS cell models revealed the combination was superior to the monotherapies in 3 of 6 VS samples, highlighting inter-tumor variability between patients consistent with observations from clinical trials with other molecular targeted agents. Dasatinib alone performed as well as the combination in the remaining three samples. Preclinically validated combination therapies hold promise for NF2 patients and warrants further study in clinical trials.
Supplementary Figure 2 from Desmoglein 2 Functions as a Receptor for Fatty Acid Binding Protein 4 in Breast Cancer Epithelial Cells
Authors: Chen Dongmei , Wirth Keith M. , Kizy Scott , Muretta Joseph M. , Markowski Todd W. , Yong Peter , Sheka Adam , Abdelwahab Hisham , Hertzel Ann V. , Ikramuddin Sayeed , Yamamoto Masato , Bernlohr David A.
Published: August 2023

S2. Predicted orientation of the F57 side chain in the apoFABP4 form.
Figure S6 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: August 2023

Single cell analyses of cell progeny of the alternate stem cells mobilized by the western diet to maintain the mucosa.
Supplementary Table 6 from ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis
Authors: Perez-Oquendo Mabel , Manshouri Roxsan , Tian Yanhua , Fradette Jared J. , Rodriguez B. Leticia , Kundu Samrat T. , Gibbons Don L.
Published: August 2023

Protein expression values of the immunoprecipitated samples
Figure 5 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Authors: Cai Ling , DeBerardinis Ralph J. , Xie Yang , Minna John D. , Xiao Guanghua
Published: August 2023

NE score–associated protein and metabolic features are largely consistent in SCLC and neuroblastoma cell lines. Heat maps visualizing the relationship between NE scores and selected functional proteomic feature (A) or metabolites (B). In each heat map, the left-side column denotes the Pearson correlation between the selected feature on the row and the NE score. The top colored rows denote NE scores and SCLC TF expression. The features were selected on the basis of NE score correlation from the SCLC cell lines, adjusted P value (P.adj) < 0.05 was used to select RPPA features and P.adj < 0.1 was used to select metabolic features. Note that although the selection was made from SCLC cell lines, a very similar pattern could be observed in neuroblastoma cell lines. Scatterplots visualizing the relationship between selected RPPA (C) and metabolic (D) features and NE scores in neuroblastoma and SCLC cell lines.
Figure 3 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Authors: Cai Ling , DeBerardinis Ralph J. , Xie Yang , Minna John D. , Xiao Guanghua
Published: August 2023

NE score is not associated with overall survival in SCLC or neuroblastoma. A, Survival association analysis for SCLC based on 79 patients from the George_2015 study. NE score is not significantly associated with overall survival in univariate Cox regression or a multivariate model controlling for sex and TNM stage. B, Meta-analysis for neuroblastoma based on seven studies and 1,531 patients. The result is also not statistically significant although significant results could be observed for individual studies, the trend was different. C, NE scores are not significantly altered in neuroblastoma relapsed samples. Paired samples from the same patients in two independent studies were compared.
Data from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: August 2023

Abstract
New Western-style diet 1 (NWD1), a purified diet establishing mouse exposure to key nutrients recapitulating levels that increase human risk for intestinal cancer, reproducibly causes mouse sporadic intestinal and colonic tumors reflecting human etiology, incidence, frequency, and lag with developmental age. Complex NWD1 stem cell and lineage reprogramming was deconvolved by bulk and single-cell RNA sequencing, single-cell Assay for Transposase-Accessible Chromatin using sequencing, functional genomics, and imaging. NWD1 extensively, rapidly, and reversibly, reprogrammed Lgr5hi stem cells, epigenetically downregulating Ppargc1a expression, altering mitochondrial structure and function. This suppressed Lgr5hi stem cell functions and developmental maturation of Lgr5hi cell progeny as cells progressed through progenitor cell compartments, recapitulated by Ppargc1a genetic inactivation in Lgr5hi cells in vivo. Mobilized Bmi1+, Ascl2hi cells adapted lineages to the nutritional environment and elevated antigen processing and presentation pathways, especially in mature enterocytes, causing chronic, protumorigenic low-level inflammation. There were multiple parallels between NWD1 remodeling of stem cells and lineages with pathogenic mechanisms in human inflammatory bowel disease, also protumorigenic. Moreover, the shift to alternate stem cells reflects that the balance between Lgr5-positive and -negative stem cells in supporting human colon tumors is determined by environmental influences. Stem cell and lineage plasticity in response to nutrients supports historic concepts of homeostasis as a continual adaptation to environment, with the human mucosa likely in constant flux in response to changing nutrient exposures.
Implications:
Although oncogenic mutations provide a competitive advantage to intestinal epithelial cells in clonal expansion, the competition is on a playing field dynamically sculpted by the nutritional environment, influencing which cells dominate in mucosal maintenance and tumorigenesis.
Data from ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis
Authors: Perez-Oquendo Mabel , Manshouri Roxsan , Tian Yanhua , Fradette Jared J. , Rodriguez B. Leticia , Kundu Samrat T. , Gibbons Don L.
Published: August 2023

Abstract
Epithelial-to-mesenchymal transition results in loss of specialized epithelial cell contacts and acquisition of mesenchymal invasive capacity. The transcription repressor zinc finger E-box-binding homeobox 1 (ZEB1) binds to E-boxes of gene promoter regions to suppress the expression of epithelial genes. ZEB1 has inconsistent molecular weights, which have been attributed to posttranslational modifications (PTM). We performed mass spectrometry and identified K811 acetylation as a novel PTM in ZEB1. To define the role of ZEB1 acetylation in regulating function, we generated ZEB1 acetyl-mimetic (K811Q) and acetyl-deficient (K811R) mutant-expressing non–small cell lung cancer cell lines (NSCLC). We demonstrate that the K811R ZEB1 (125 kDa) has a shorter protein half-life than wild-type (WT) ZEB1 and K811Q ZEB1 (∼225 kDa), suggesting that lack of ZEB1 acetylation in the lower molecular weight form affects protein stability. Further, the acetylated form of ZEB1 recruits the nucleosome remodeling and deacetylase (NuRD) complex to bind the promoter of its target genes mir200c-141 and SEMA3F. RNA-sequencing revealed that WT ZEB1 and K811Q ZEB1 downregulate the expression of epithelial genes to promote lung adenocarcinoma invasion and metastasis, whereas the K811R ZEB1 does not. Our findings establish that the K811 acetylation promotes ZEB1 protein stability, interaction with other protein complexes, and subsequent invasion/metastasis of lung adenocarcinoma via epithelial-to-mesenchymal transition.
Implications:
The molecular mechanisms by which ZEB1 is regulated by K811 acetylation to promote protein stability, NuRD complex and promoter interactions, and function are relevant to the development of treatment strategies to prevent and treat metastasis in patients with NSCLC.
Data from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Authors: Cai Ling , DeBerardinis Ralph J. , Xie Yang , Minna John D. , Xiao Guanghua
Published: August 2023

Abstract
Lineage plasticity has long been documented in both small cell lung cancer (SCLC) and neuroblastoma, two clinically distinct neuroendocrine (NE) cancers. In this study, we quantified the NE features of cancer as NE scores and performed a systematic comparison of SCLC and neuroblastoma. We found neuroblastoma and SCLC cell lines have highly similar molecular profiles and shared therapeutic sensitivity. In addition, NE heterogeneity was observed at both the inter- and intra-cell line levels. Surprisingly, we did not find a significant association between NE scores and overall survival in SCLC or neuroblastoma. We described many shared and unique NE score–associated features between SCLC and neuroblastoma, including dysregulation of Myc oncogenes, alterations in protein expression, metabolism, drug resistance, and selective gene dependencies.
Implications:
Our work establishes a reference for molecular changes and vulnerabilities associated with NE to non-NE transdifferentiation through mutual validation of SCLC and neuroblastoma samples.
Exon Junction Complex Mediates the Cap-Independent Translation of Circular RNA
Authors: Lin Hui-Hsuan , Chang Chiu-Yuan , Huang Yi-Ren , Shen Che-Hung , Wu Yu-Chen , Chang Kai-Li , Lee Yueh-Chun , Lin Ya-Chi , Ting Wen-Chien , Chien Han-Ju , Zheng Yi-Feng , Lai Chien-Chen , Hsiao Kuei-Yang
Published: August 2023

Evidence that circular RNAs (circRNA) serve as protein template is accumulating. However, how the cap-independent translation is controlled remains largely uncharacterized. Here, we show that the presence of intron and thus splicing promote cap-independent translation. By acquiring the exon junction complex (EJC) after splicing, the interaction between circRNA and ribosomes was promoted, thereby facilitating translation. Prevention of splicing by treatment with spliceosome inhibitor or mutating splicing signal hindered cap-independent translation of circRNA. Moreover, EJC-tethering using Cas13 technology reconstituted EJC-dependent circRNA translation. Finally, the level of a coding circRNA from succinate dehydrogenase assembly factor 2 (circSDHAF2) was found to be elevated in the tumorous tissues from patients with colorectal cancer, and shown to be critical in tumorigenesis of colorectal cancer in both cell and murine models. These findings reveal that EJC-dependent control of circSDHAF2 translation is involved in the regulation of oncogenic pathways.

Implications:

EJC-mediated cap-independent translation of circRNA is implicated in the tumorigenesis of colorectal cancer.
Supplementary Table S3 from Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Authors: Gupta Harshath , Inoue Hitoshi , Nakai Yasutomo , Nakayama Masashi , Jones Tracy , Hicks Jessica L. , Kumar Balasubramanian , Gurel Meltem , Nelson William G. , De Marzo Angelo M. , Yegnasubramanian Srinivasan
Published: August 2023

Supplementary Table S3 shows the phased methylation of the GSTP1 promoter region across 908 alleles, or clones, classified by density of methylation.
Supplemental Table 2 from Polymorphisms in the Nonhomologous End-joining DNA Repair Pathway are Associated with HPV Integration in Cervical Dysplasia
Authors: Geris Jennifer M. , Amirian E. Susan , Marquez-Do Deborah A. , Guillaud Martial , Dillon Laura M. , Follen Michele , Scheurer Michael E.
Published: August 2023

Supplemental Table 2: Integration assay primer and probe sequences
Data from Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Authors: Gupta Harshath , Inoue Hitoshi , Nakai Yasutomo , Nakayama Masashi , Jones Tracy , Hicks Jessica L. , Kumar Balasubramanian , Gurel Meltem , Nelson William G. , De Marzo Angelo M. , Yegnasubramanian Srinivasan
Published: August 2023

Abstract
Glutathione S-transferase pi 1 (GSTP1) is lowly expressed in normal prostate luminal cells and becomes induced in most proliferative inflammatory atrophy (PIA) lesions. GSTP1 becomes silenced in prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma (CaP) via cytosine-phospho-guanine (CpG) island promoter hypermethylation. However, GSTP1 methylation patterns in PIA and PIN, and their relationship to patterns in CaP are poorly understood. We used bisulfite genomic sequencing to examine patterns of GSTP1 promoter CpG island methylation in laser capture microdissected benign, PIA, PIN, and CaP regions from 32 subjects that underwent radical prostatectomy. We analyzed 908 sequence clones across 24 normal epithelium, 37 PIA, 18 PIN, and 23 CaP regions, allowing assessment of 34,863 CpG sites with allelic phasing. Normal and PIA lesions were mostly unmethylated with 0.52 and 1.3% of total CpG sites methylated, respectively. PIN and CaP lesions had greater methylation with 24% and 51% of total CpG sites methylated, respectively. The degree of GSTP1 methylation showed progression from PIA << PIN < CaP. PIN lesions showed more partial methylation compared with CaP lesions. Partially methylated lesions were enriched for methylation changes at AP1 and SP1 transcription factor binding sites. These results demonstrate that methylation density in the GSTP1 CpG island in PIN was intermediate relative to that in normal prostate epithelium/PIA and CaP lesions. These results are consistent with gradual spreading of DNA methylation centered at the SP1/AP1 transcription factor binding sites in precursor lesions, with subsequent spreading of methylation across the entire CpG island in transition to CaP.
Prevention Relevance:
DNA hypermethylation at the GSTP1 promoter progressively spreads from being unmethylated in normal prostate to intermediate levels in precursor lesions to extensive methylation in cancer. This molecular progression of GSTP1 promoter methylation patterns in early prostate carcinogenesis could be useful for identification and interception of prostate cancer precursors.
Data from Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan (GTX-CI) as First-line Treatment for Metastatic Pancreatic Cancer
Authors: Wilbur H. Catherine , Durham Jennifer N , Lim Su Jin , Purtell Katrina , Bever Katherine M. , Laheru Daniel A. , De Jesus-Acosta Ana , Azad Nilofer S. , Wilt Bradley , Diaz Luis A. , Le Dung T. , Wang Hao
Published: August 2023

Abstract
Purpose:

Treatment of advanced pancreatic cancer with a single therapeutic at a maximal dose has been largely ineffective at increasing survival. Combination therapies are commonly studied but often limited by toxicity. We previously showed that low-dose multi-agent therapy with gemcitabine, docetaxel (taxotere), capecitabine (xeloda) and cisplatin (GTX-C) was safe, well-tolerated and effective. Here, we hypothesize that adding irinotecan to GTX-C may improve survival with minimal toxicity.

Patients and Methods:

Patients with treatment-naïve metastatic pancreatic adenocarcinoma were treated with GTX-CI. Treatment consisted of capecitabine 500 mg BID on days 1-14 and gemcitabine 300 to 500 mg/m2, docetaxel 20 mg/m2, cisplatin 15 to 20 mg/m2 and irinotecan 20 to 60 mg/m2 on days 4 and 11 of a 21-day cycle. The primary objective was nine-month overall survival (OS). Secondary objectives included response rate (RR), disease control rate (DCR), progression free survival (PFS) and OS.

Results:

The regimen was well-tolerated. The recommended phase 2 dose was gemcitabine 500mg/m2, docetaxel 20mg/m2, capecitabine 500 mg/m2, cisplatin 20mg/m2 and irinotecan 20mg/m2. Median follow-up in phase II was 11.02 months (2.37 -45.17). Nine-month OS rate was 57% (95% CI: [41%, 77%]. RR was 57% (95% CI: [37%, 75%] 50% PR and 7% CR). DCR was 87% (95% CI: [69%, 96%]). Median OS and PFS were 11.02 (95% CI: [8.54, 21.09]) and 8.34 (95% CI: [6.34, NA]) months, respectively.

Conclusions:

The addition of irinotecan to GTX-C was safe and well-tolerated. While the study did not meet its primary objective, the responses were clinically meaningful using a well-tolerated regimen.
Elementos principais da geometria descritiva
Authors:   Universidade de São Paulo. Escola Politécnica, Kawano Alexandre , Petreche João Roberto Diego ,   Universidade de São Paulo. Escola Politécnica
Published: August 2023

A Geometria Descritiva tem como objetivo representar objetos tridimensionais em planos bidimensionais, utilizando projeções de elementos geométricos como pontos e retas. É baseada em um conjunto de princípios que permitem representar a forma e a posição de objetos tridimensionais em um sistema de projeções ortogonais. Ela permite aos profissionais visualizarem e analisarem objetos complexos em um plano bidimensional, facilitando o processo de projeto, construcção e fabricação. O objetivo principal desta obra é apresentar ao leitor os fundamentos da geometria descritiva, que é uma ferramenta gráfica para a solução de problemas geométricos no espaço. A experiência dos autores indica que o tema, apesar de ser de fácil leitura, é de difícil aprendizado. A melhor forma de se aprender a matéria, é fazendo exercícios.
Reaction of soybean cultivars to two races of Meloidogyne enterolobii and their aggressiveness under plastic house conditions
Authors: Verssiani Jorge B.S. , Souza Caio F.B. , Santos Paulo S. , Arias Carlos A.A. , Cares Juvenil E. , Carneiro Regina M.D.G.
Published: August 2023

Limited information is available regarding the susceptibility or resistance of soybean cultivars to Meloidogyne enterolobii. Recently, a new race of this species was detected in Brazil parasitising cotton and soybean. This nematode has the potential to pose a problem in both of these crops, since it is pathogenic and virulent to several economically important plants that have resistance genes to other Meloidogyne species. The aim of this study was to assess the responses of EMBRAPA’s main soybean cultivars with confirmed resistance to M. incognita and M. javanica to the two races of M. enterolobii detected in Brazil. Additionally, this study aimed to characterise the aggressiveness of these nematode races. The experiments were conducted in a plastic house, in a factorial scheme with 16 soybean cultivars × two M. enterolobii races (guava and cotton), totalling 32 treatments × eight replications, and evaluated with two replications over time. Soybean sowing took place in pots containing 1.7 l of a mixture of soil, sand and Bioplant® substrate (1:1:1), previously autoclaved. Each soybean plant was inoculated with 5000 eggs of M. enterolobii. After 75 days for the first experiment, and 90 days for the second, the following variables were evaluated: gall index (GI), egg mass index (EMI), total number of eggs per g root (NEGR) and the reproduction factor (RF). Both races of M. enterolobii showed reproductive ability in all soybean genotypes (with or without known genetic resistance), albeit with moderate to low values in comparison to their reproduction on tomato plants. The race from cotton was considered statistically more aggressive than the guava population on soybean cultivars. Only ‘BRS 7180 IPRO’ was moderately resistant to both races in both experiments. In view of the importance and prospects for expansion of the soybean crop, the findings of this study contribute to a better understanding of the resistance and aggressiveness exhibited by the two races of M. enterolobii, Moreover, the study highlights the significant challenge that lies ahead in developing breeding programmes to select soybean genotypes with multiple resistance to Meloidogyne spp.
Aphelenchoides tenuis n. sp. (Tylenchina: Aphelenchoididae) found in loblolly pine logs imported from the USA
Authors: Gu Jianfeng , Fang Yiwu , Ma Xinxin , Sánchez-Monge Alcides
Published: August 2023

Aphelenchoides tenuis n. sp. found in loblolly pine (Pinus taeda L.) logs imported from the USA, is described. It is characterised by a very slim body (a = 56.8 (45.8-67.2) and 49.1 (42.2-54.2) in males and females, respectively), three incisures in the lateral field, short stylet (9-12 μm), the excretory pore located at the level of nerve ring, the vagina is not sclerotised, the vulva has slightly protruding lips and lacks a flap and the post-uterine sac is well developed, forming ca 36.2 (28.4-48.2)% of the vulva to anus distance. The spicules are smoothly arcuate, the apex and rostrum are rounded and well developed, and the dorsal limb is 23.3 (21.1-25.5) μm long, without a hook-like structure at the distal tip. The male tail bears three pairs (2 + 2 + 2) of caudal papillae. The tail of both sexes is sub-cylindrical, the terminus bearing a bluntly pointed mucron with tiny nodular protuberances. The new species belongs to the Group 2 category of Aphelenchoides species sensu Shahina and is defined as A2-B1/2-C1-D1/2-E2-F2/3 according to the categorisation codes of OEPP/EPPO. Phylogenetic analysis based on 18S and 28S D2-D3 of rDNA, along with ITS and mtCOI, confirmed its status as a new species.
Economic Governance Quality and Effective Taxation System in Africa
Authors: Bekana Dejene M.
Published: August 2023

The study aims at examining the effect of Economic governance institutions on tax revenue mobilization using an empirical panel dataset from 30 African countries for the period 1996–2018. The empirical estimation methods employed in this study is based on Quantile Regression techniques. To this end, one bundled economic governance institution indicator (i.e., general economic governance) is employed. The inspiration for this estimation technique is based on two fundamental reasons. First, the argument that the effect of governance quality on taxation effectiveness is contingent on the existing level of tax revenue mobilization. Second, the economic governance – tax revenue mobilization policies, to be effective, need to be tailored differently across countries with low, intermediate and high levels of tax mobilization effort. The general findings are as follows: First, development in economic governance institutions promotes tax mobilization effort. Second, the effect of economic governance is stronger in terms of significance and magnitude for direct taxes than for indirect taxes. Third, in most of the cases, the impact of economic governance institutions is higher in terms of magnitude in the upper quantiles of the economic governance distributions. The results remain robust over alternative econometric estimation techniques.
Angels of Destruction (Mal’akhei Ḥabalah): Two Millennia of Jewish Horror
Authors: Kabalek Kobi , Zinger Nimrod
Published: August 2023

This article traces the meanings and uses of the Hebrew concept mal’akhei ḥabalah [angels of destruction], a common designation for monsters that has been mentioned in Jewish texts for over two millennia. Thus far, scholars have considered mal’akhei ḥabalah only in isolated contexts. In contrast, we examine these monsters’ long history, which provided Jews with familiar horror images and figures to visualize and embody experienced and anticipated fears and threats. We argue that Jewish references to them were intended to horrify in order to deter people from sin and to express God’s might and authority, thus maintaining religious and communal order in Jewish societies. At the same time, mal’akhei ḥabalah were used to articulate the crises that threatened and challenged the existing social and political order. Although mal’akhei ḥabalah developed within religious interpretations, by the modern era they expanded their applications and relevance for various avenues of Jewish life.
Gender Differences in Disaffiliation from Orthodox Judaism
Authors: Keller Yehudis , Chavarga Alla , Hirsch Estee , Eisen Pesach , Miles Rona
Published: August 2023

Religious disaffiliation from Orthodox Judaism is becoming more prevalent and of interest to researchers. In Orthodox Judaism, though gender norms dictate everyday life, research on the role of gender in disaffiliation is scarce. This study analyzed data from a parent study describing the personal experiences of men and women raised as Orthodox Jews who either disaffiliated from the practice (Nwomen = 153, Nmen = 153) or continued practicing (Nwomen = 168, Nmen = 146), examined through the lens of gender. Gender differences had a divergent pattern: disaffiliated women reported adverse social/emotional experiences at a significantly higher rate than disaffiliated men and all affiliates, while all men reported adverse education experiences at a significantly higher rate than women. These patterns may, in part, be due to community norms and differential willingness to report outcomes by disaffiliated and affiliated individuals. Our findings highlight the influence of gender on the experiences within the religious community and the complex process of disaffiliation.
Agouti historiography: the problem of widespread lexical forms and deep linguistic history in Central and South America
Authors: Urban Matthias
Published: August 2023

Throughout Central and South America, similar words for salient rodent species, the agoutis (Dasyprocta spp.), reconstruct to some of the most ancient known languages families in the species’ range, including Chibchan (*’kuri), Cariban (*akuri), Tupian (*akutˀi), and others. Unless these are dismissed as mere chance, this makes for as interesting as problematic evidence for deep linguistic history: what mechanisms account for the striking similarities that must go back far into prehistory? One possibility is that the words are lexical evidence for very old genealogical connections. While this is a possibility worth bearing in mind also in light of current and past suggestions that involve some of the relevant groups, we cannot conclude that this is indeed the case on the basis of the available evidence. Another, and perhaps less costly, hypothesis is very old borrowing involving relevant proto-languages or their ancestors However, is this a plausible scenario? On the basis of a large set of data featuring more than 400 languages from Central and South America, I show that neighboring languages have relatively frequently borrowed agouti-words from one another, involving reflexes of the above forms, but also others. This shows that it is natural to expect borrowing my. In either case, the similarities likely demonstrate very old interactions between the mentioned lineages, something with interesting implications on homeland hypotheses and scenarios of early spread.
Time, Experience and Belief
Authors: Skokowski Paul
Published: August 2023

A model is proposed for human-like information-gathering and -utilizing systems. This model uses sensory experience, and subsequent processed belief contents, to provide a notion of psychological time for these agents. This model shows how a narrative can be formed to provide concepts of a ‘now’, a ‘past’, a ‘future’, and perhaps even a ‘flow’ for psychological time. The proposal is that conscious, occurrent access at any moment to registers with different kinds of contents warrants beliefs about relations in time, while recognizing differences between interpretations of psychological time and time as understood in physical theories.
Stormy Images: Elemental Kinetics in the Recent Films of Takashi Makino (2018–2021)
Authors: Turan Kaya
Published: August 2023

This article examines the movements of the elements (water, air, fire, and earth) in the recent (2018–2021) films of Japanese experimental filmmaker Takashi Makino. It proposes that Makino’s unique style of filmmaking – which consists of layering thousands of moving images of the natural world on top of each other – expresses and encompasses elemental tensions between form and formlessness, clarity and obscurity, and identity and transformation. Taking the storm as an ecological force which foregrounds elemental kinetics, Makino’s films are analyzed in their capacity to disclose natural motion. This allows for a renewed conception of the elemental, understood as process and flow rather than individual units. An elemental politics of the storm emerges, which calls for the fostering of productive and complex movement rather than the stasis of conservation.
Untamed Storms: Cinema’s Oceanic Contingency and Mati Diop’s Atlantics
Authors: Kent Laurence
Published: August 2023

The ocean, for Jean Epstein, figures the disruption that the cinematograph offers for human perception, presenting a nonhuman view on the world. This article will critically engage with Epstein’s writings on water to reflect on Mati Diop’s Atlantics (2019) and its particular conception of the oceanic. Atlantics positions the ocean within the perspectives of its filmic subjects but also in excess of them. This perspectival nature of the oceanic speaks to a liminal space between male and female, living and dead, human and nonhuman, which mirrors contemporary debates within Black studies around the exclusion of Blackness from the normative category of the human: the contingency of the definition of humanity based on racial exclusion. As a result, it is not only the nonhuman perspective that the ocean provides in Atlantics, but a spectral haunting of those deemed other than human by global capitalism, which disrupts, as a queer prophecy, the veneer of necessity that the neocolonial order requires to sustain itself.
Animated Waters and the Circulation of Indigenous Instruction
Authors: Hearne Joanna
Published: August 2023

While water as setting and as mirror have driven animation technologies in mainstream American animated features (requiring, in Disney’s 1937 Snow White, the enormous resources of the multiplane camera), contemporary Indigenous productions activate another relationship of viewer to screen and viewer to water, converging to form a new Indigenous screen imaginary that connects instruction with care. This article traces the integration of North American Indigenous animation aesthetics with interrelated relationships and obligations around water and water protection. Drawing on examples from an expanding corpus of short animated productions, I argue that Indigenous ways of envisioning water present viewers with instruction towards action: water conveys a teaching. Following Lenape critic Joanne Barker’s turn to water as an analytic – “a water that (in)forms, a water that instructs” – I explore Indigenous animation of water as both pedagogy and technology, a conjunction that foregrounds human creative authorship even as it decenters the human in favor of water as a teacher.
Taxonomic implications of leaf epidermal characteristics in subfamily Caesalpinioideae (Leguminosae)
Authors: PANDEY SHIVARAMAN , CHAUDHARY LAL BABU , SINGH LAV , SRIVASTAVA RAVI PRAKASH , SINGH ARPIT , MSIHRA AJAY KUMAR , DIXIT POOJA , SAXENA GAURI
Published: August 2023

This paper deals with the foliar epidermal anatomy of 25 species belonging to 14 genera (i.e., Bauhinia, Caesalpinia, Cassia, Delonix, Guilandina, Hardwickia, Libidibia, Lysiphyllum, Parkinsonia, Peltophorum, Phanera, Saraca, Senna and Tamarindus) of subfamily Caesalpinioideae (Leguminosae) using light microscopy (LM). The target species were collected from different regions (Terai Region, Gangetic Plain, Vindhyan Region and Semiarid region) of Uttar Pradesh, India. Several leaf micromorphological characters such as anticlinal wall pattern, epidermal cells shape, stomatal complex andtrichomes were assessed in the present study. Both quantitatively and qualitativelystudy revealed that species understudy mostly consisted of polygonal epidermal cells with straight anticlinal walls, were amphi stomatic with paracytic stomata, non-glandular and unicellular trichomes. An attempt was also made to establish phylogenetic relationships in members of Caealpinioideae growing in Uttar Pradesh on the basis of these characters.
Dictyosporium duliujiangense sp. nov. (Dictyosporiaceae, Pleosporales) from freshwater habitat in Guizhou Province, China
Authors: LIU LING-LING , SONG LIAN-CHAI , GU XIAO-FENG , WEI QUAN-QUAN , ZHANG MENG , LIU ZUO-YI , GOU JIU-LAN
Published: August 2023

A survey of the taxonomy and diversity of freshwater fungi from Karst Plateau wetlands in Guizhou Province, China, three fresh collections were collected from a freshwater river. They have cheiroid, digitate, dictyosporous conidia with one or two hyaline appendages. Phylogenetic analysis of the combined ITS, LSU and tef1-α sequence data support their placement with genera Dictyocheirospora and Dictyosporium (Dictyosporiaceae, Pleosporales). Two collections represent the same species, Dictyocheirospora rotunda. The other collection is introduced as a new species Dictyosporium duliujiangense. An updated phylogenetic backbone tree, descriptions and illustrations of the two taxa are provided for Dictyosporiaceae.
A new species of Cristarmadillidium from central Spain with remarks on Estenarmadillidium and Iberiarmadillidium (Isopoda: Oniscidea: Armadillidiidae)
Authors: GARCIA LLUC
Published: August 2023

The terrestrial isopod Cristarmadillidium cabanillasi sp. nov. (Isopoda: Oniscidea: Armadillidiidae) is described from Sierra Oeste and from the foothills of Sierra de Guadarrama (Madrid, Spain) in the Iberian Peninsula. The new species is the second of this genus to be discovered in the southwestern/central Iberian regions. In addition, morphological aspects of other endemic species of the related genera Estenarmadillidium and Iberiarmadillidium, are also discussed.
1. Introduction
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.

Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.

Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.
5. Structured Decisions and Decision Processes
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.

Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.

Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.
6. Procurement Competence
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.

Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.

Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.
8. Project Portfolios
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.

Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.

Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.
9. Managing Projects
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.

Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.

Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.