bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenotyping in the era of genomics: MaTrics—a digital character matrix to document mammalian phenotypic traits
Authors: Stefen Clara , Wagner Franziska , Asztalos Marika , Giere Peter , Grobe Peter , Hiller Michael , Hofmann Rebecca , Jähde Maria , Lächele Ulla , Lehmann Thomas , Ortmann Sylvia , Peters Benjamin , Ruf Irina , Schiffmann Christian , Thier Nadja , Unterhitzenberger Gabriele , Vogt Lars , Rudolf Matthias , Wehner Peggy , Stuckas Heiko
Published: December 2021

A new and uniquely structured matrix of mammalian phenotypes,MaTrics(MammalianTraits for Comparative Genomics) in a digital form is presented. By focussing on mammalian species for which genome assemblies are available,MaTricsprovides an interface between mammalogy and comparative genomics.

MaTricswas developed within a project aimed to find genetic causes of phenotypic traits of mammals usingForward Genomics.This approach requires genomes and comprehensive and recorded information on homologous phenotypes that are coded as discrete categories in a matrix.MaTricsis an evolving online resource providing information on phenotypic traits in numeric code; traits are coded either as absent/present or with several states as multistate. The state record for each species is linked to at least one reference (e.g., literature, photographs, histological sections, CT scans, or museum specimens) and soMaTricscontributes to digitalization of museum collections. Currently,MaTricscovers 147 mammalian species and includes 231 characters related to structure, morphology, physiology, ecology, and ethology and available in a machine actionable NEXUS-format*. FillingMaTricsrevealed substantial knowledge gaps, highlighting the need for phenotyping efforts. Studies based on selected data fromMaTricsand usingForward Genomicsidentified associations between genes and certain phenotypes ranging from lifestyles (e.g., aquatic) to dietary specializations (e.g., herbivory, carnivory). These findings motivate the expansion of phenotyping inMaTricsby filling research gaps and by adding taxa and traits. Only databases likeMaTricswill provide machine actionable information on phenotypic traits, an important limitation to genomics.MaTricsis available within the data repository Morph·D·Base (www.morphdbase.de).
In and Out in Senegal: Unearthing Queer Roots in Mohamed Mbougar Sarr’s De purs hommes
Authors: Bryson Devin
Published: December 2021

Mohamed Mbougar Sarr’s 2018 novel De purs hommes fictionalizes recent incidents of homophobia in Senegal to interrogate the relationship between queer men and social dynamics in the country. This article demonstrates that the novel deploys multidirectional critical discourse and oblique narrative tactics to highlight the foundational role in Senegalese culture and society of the fraught dichotomy between private and public life. Bryson contends that the novel unearths these queer roots in order to incorporate all normative identities into queer existence, conceptually blurring the social barriers to LGBTQ+ agency in the country.
Data linkage for early intervention in the UK: Parental social license and social divisions
Authors: Edwards Rosalind , Gillies Val , Gorin Sarah
Published: December 2021

Electronic linking of public records and predictive analytics to identify families for preventive early intervention increasingly is promoted by governments. We use the concept of social license to address questions of social legitimacy, agreement, and trust in data linkage and analytics for parents of dependent children, who are the focus of early intervention initiatives in the UK. We review data-steered family policy and early intervention operational service practices. We draw on a consensus baseline analysis of data from a probability-based panel survey of parents, to show that informed consent to data linkage and use is important to all parents, but there are social divisions of knowledge, agreement, and trust. There is more social license for data linkage by services among parents in higher occupation, qualification, and income groups, than among Black parents, lone parents, younger parents, and parents in larger households. These marginalized groups of parents, collectively, are more likely to be the focus of identification for early intervention. We argue that government awareness-raising exercises about the merits of data linkage are likely to bolster existing social license among advantaged parents while running the risk of further disengagement among disadvantaged groups. This is especially where inequalities and forecasting inaccuracies are encoded into early intervention data gathering, linking, and predictive practices, with consequences for a cohesive and equal society.
Impact of decreasing vancomycin exposure on acute kidney injury in stem cell transplant recipients
Authors: Hambrick Horace Rhodes , Greco Kimberly F. , Weller Edie , Ganapathi Lakshmi , Lehmann Leslie E. , Sandora Thomas J.
Published: December 2021

Objective:

To evaluate the change in vancomycin days of therapy (DOT) and vancomycin-associated acute kidney injury (AKI) after an antimicrobial stewardship program (ASP) intervention to decrease vancomycin use in stable patients after hematopoietic stem cell transplantation (HSCT).

Design:

Retrospective cohort study and quasi-experimental interrupted time series analysis. Change in unit-level vancomycin DOT per 1,000 inpatient days after the intervention was assessed using segmented Poisson regression. Subject-specific risk of vancomycin-associated AKI was evaluated using a random intercept logistic regression model with mediation analysis.

Setting:

HSCT unit at a single quaternary-care pediatric hospital.

Participants:

Inpatients aged 3 months and older who underwent HSCT between January 1, 2015, and March 31, 2019 (27 months before and after the intervention) who received any dose of vancomycin.

Intervention:

An ASP intervention in April 2017 creating a new practice guideline to decrease prolonged (>72 hours) vancomycin courses for stable HSCT patients with febrile neutropenia.

Results:

Overall, 439 vancomycin exposures (234 before the intervention and 205 after the intervention) occurring across 300 transplants and 259 subjects were included. The mean vancomycin DOT was 307 per 1,000 inpatient days (95% confidence interval [CI], 272–342) and decreased after the intervention to 207 per 1,000 inpatient days (95% CI, 173–240). In multivariable analyses, the odds of AKI in the postintervention period were 37% lower than in the preintervention period (adjusted OR, 0.63; 95% CI, 0.42–0.95; P = .0268); 56% of the excess risk was mediated by vancomycin DOT.

Conclusions:

An ASP intervention successfully decreased vancomycin use after HSCT and resulted in a decrease in AKI. Reducing empiric antibiotic exposure for stable patients after HSCT can improve clinical outcomes.
Viscous transfer of momentum across a shallow laminar flow
Authors: Devauchelle O. , Popović P. , Lajeunesse E.
Published: December 2021

In a shallow channel, the flow transfers most of its momentum vertically. Based on this observation, one often neglects the momentum that is transferred across the stream – the core assumption of the shallow-water theory. In the context of viscous flows, this approximation is referred to as the ‘lubrication theory’, in which one assumes that the shear stress exerted by the fluid on the substrate over which it flows is proportional to its velocity. Here, we revise this theory to account for the momentum that viscosity transfers across a shallow laminar flow, while keeping the problem low-dimensional. We then test the revised lubrication theory against analytical and numerical solutions of the exact problem. We find that, at a low computational cost, the present theory represents the actual flow more accurately than the classical lubrication approximation. This theoretical improvement, devised with laboratory rivers in mind, should also apply to other geophysical contexts, such as ice flows or forming lava domes.
Under an iron sky: On the entropy at the start of the Universe
Authors: Barnes Luke A. , Lewis Geraint F.
Published: December 2021

Curiously, our Universe was born in a low entropy state, with abundant free energy to power stars and life. The form that this free energy takes is usually thought to be gravitational: the Universe is almost perfectly smooth, and so can produce sources of energy as matter collapses under gravity. It has recently been argued that a more important source of low-entropy energy is nuclear: the Universe expands too fast to remain in nuclear statistical equilibrium, effectively shutting off nucleosynthesis in the first few minutes, providing leftover hydrogen as fuel for stars. Here, we fill in the astrophysical details of this scenario and seek the conditions under which a Universe will emerge from early nucleosynthesis as almost-purely iron. In so doing, we identify a hitherto-overlooked character in the story of the origin of the second law: matter–antimatter asymmetry.
Quantitative risk–benefit assessment of Portuguese fish and other seafood species consumption scenarios
Authors: Carvalho Catarina , Correia Daniela , Severo Milton , Afonso Cláudia , Bandarra Narcisa M. , Gonçalves Susana , Lourenço Helena M. , Dias Maria Graça , Oliveira Luísa , Nabais Pedro , Carmona Paulo , Monteiro Sarogini , Borges Marta , Lopes Carla , Torres Duarte
Published: December 2021

Portugal has high fish/seafood consumption, which may have both risks and benefits. This study aims to quantify the net health impact of hypothetical scenarios of fish/seafood consumption in the Portuguese population using a risk–benefit assessment methodology. Consumption data from the National Food, Nutrition and Physical Activity Survey 2015–2016 (n 5811) were used to estimate the mean exposure to methylmercury and EPA + DHA in the current and the alternative scenarios considered. Alternative scenarios (alt) were modelled using probabilistic approaches to reflect substitutions from the current consumption in the type of fish/seafood (alt1: excluding predatory fishes; alt2: including only methylmercury low-level fishes) or in the frequency of weekly fish/seafood consumption (alt3 to alt6: 1, 3, 5 or 7 times a week, replacing fish/seafood meals with meat or others). The overall health impact of these scenarios was quantified using disability-adjusted life years (DALY). In the Portuguese population, about 11 450 DALY could be prevented each year if the fish/seafood consumption increased to a daily basis. However, such a scenario would result in 1398 extra DALY considering the consumption by pregnant women and the respective risk on fetal neurodevelopment. Our findings support a recommendation to increase fish/seafood consumption up to 7 times/week. However, for pregnant women and children, special considerations must be proposed to avoid potential risks on fetal neurodevelopment due to methylmercury exposure.
Triassic trachytic volcanism in the Bangong–Nujiang Ocean: geochemical and geochronological constraints on a continental rifting event
Authors: Zheng Ming , Song Yang , Li Haifeng , Guilmette Carl , Tang Juxing , Zhang Qing , Liu Zhibo , Li Faqiao
Published: December 2021

The Bangong–Nujiang suture zone (BNSZ), which separates the Gondwana-derived Qiangtang and Lhasa terranes, preserves limited geological records of the Bangong–Nujiang Ocean (BNO). The timing of opening of this ocean has been hotly debated due to the rare and complicated rock records in the suture zones, which span over 100 Ma from Carboniferous–Permian to Early Jurassic time, based on geological, palaeontological and palaeomagnetic data. A combination of geochemical, geochronological and isotopic data are reported for the Riasairi trachytes, central BNSZ, northern Tibet, to constrain its petrogenesis and tectonic settings. Zircon U–Pb dating by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) yields mean ages of 236 Ma. Geochemically, these rocks are high-K calc-alkaline with moderate SiO2 (59.1–67.5 wt%) and high K2O + Na2O (8.1–11.6 wt%) contents. They are enriched in light rare earth elements with negative Eu anomalies, and show enrichments in high-field-strength elements with positive ‘Nb, Ta’ anomalies, similar to the intra-continental rift setting-related felsic lavas from the African Rift System. The high positive zircon ϵHf(t) and bulk ϵNd(t) values, as well as high initial Pb isotopes, imply a heterogeneous source involving both asthenospheric and subcontinental lithospheric mantle. The field and geochemical data jointly suggest that the Riasairi trachytes within the Mugagangri Group were formed in a continental rift setting. We interpret that the continental-rift-related Riaisairi trachytic lavas as derived from the southern margin of the Qiangtang terrane, implying that the BNO would have opened by Middle Triassic time, well after the commonly interpreted break-up of the Qiangtang terrane from Gondwana.
Disseminating and Containing Communist Propaganda to Overseas Chinese in Southeast Asia through Hong Kong, the Cold War Pivot, 1949–1960
Authors: Mok Florence
Published: December 2021

This article explores an understudied aspect in Asia's Cold War history: how the Chinese Communist Party (CCP) used Hong Kong as a Cold War pivot to produce and disseminate left-wing literature for overseas Chinese living in Southeast Asia. It argues that the CCP's expanding cultural influence can be attributed to the Party's commercial acumen. Operating within a permissive colonial regulatory regime, the CCP expanded its control of local and regional markets for left-wing printed materials. The content of CCP literature was inevitably propagandistic – that is, shaped by the changing demands of the Chinese government's foreign policy and by a need to attract foreign remittances and accommodate socialist transformation at home. Hong Kong's emergence as a pivot in propaganda wars that were global in scope created tensions between the United States and Britain, and led governments in Southeast Asia to strengthen state controls on imported communist media. As such, this article makes an original contribution to Hong Kong colonial history and deepens our understanding of transnational dynamics within Southeast Asia.
Effects of cultivar, seed rate, N rate and plant growth regulator on key processing quality parameters of winter and spring-sown oats
Authors: McCabe C. P. , Burke J. I.
Published: December 2021

The effects of three seeding rates (250, 350 and 450 seeds/m2), six applied N rates (40, 70, 100, 130, 160 and 190 kg N/ha) and the application of plant growth regulator on the grain quality of two spring oat cultivars (Husky and Keely) were evaluated at four spring-sown sites over a 3-year period (2016–2018). The same cultivars, seeding rates and five applied N rates (80, 110, 140, 170 and 200 kg N/ha) were evaluated at three winter-sown sites, in 2017–2019. Keely had a significantly higher kernel content (KC) in spring (0.7%) and winter-sown (0.6%) oats. Specific weight (SW) decreased as N rate increased in spring-sown crops (1 kg/hl) with no effect observed in winter-sown oats. Hullability (HB) increased (0.92%) in spring-sown crops as N rate increased with a reduction (0.9%) observed when winter-sown. Increases in grain protein percentage (GPP) were observed in spring (1.8%) and winter (1.2%) sowings in response to N rate. The application of plant growth regulator reduced SW (0.4 kg/hl), GPP (0.3%), KC (0.6%) with no effect on HB. Kernel size was highly responsive too applied N rate, with reductions in grains >2.5 mm and increases in grains of smaller size observed as N rate increased. HB had a marked relationship to kernel size with GP inconsistently linked to SW. The results of this study suggest that cultivar, N rate and PGR application are of importance to milling quality and that changes in grain size in response to agronomic practices contribute to changes in specific weight and hullability.
A review of the genusNarcissiaGray, 1840 (Echinodermata: Asteroidea: Ophidiasteridae)
Authors: Cunha Rosana , Tavares Marcos
Published: December 2021

Since the taxonomic revision of the Ophidiasteridae by H.L. Clark (1921), in which 20 genera were recognized as valid, several new genera and species were included in this family, and the boundaries between some of them became largely arbitrary. This also applies toNarcissiaGray, 1840, whose morphology and taxonomy are still very poorly understood today. The main goals of this research were: review the taxonomy of the genusNarcissia, from morphological studies; redescribeN.trigonariaSladen, 1889s.str.; characterizeN.canariensis(d'Orbigny, 1839) andN.gracilisA.H. Clark, 1916, the two valid species most similar toN.trigonaria; review the validity ofN.ahearnaePawson, 2007 andN.trigonariavar.helenaeMortensen, 1933; review the validity ofN.gracilis malpeloensisDowney, 1975. Altogether 370 specimens were analysed. All morphological structures of taxonomic importance have been illustrated, and, for the first time, the internal characters of this group were studied, from electron microscopy and microtomography. A new diagnosis for the genusNarcissiawas constructed.Narcissia trigonariawas redescribed from a large specimen, from the type locality (Bahia, Brazil).Narcissia ahearnaeis considered a valid species, andN.canariensisandN.trigonariadistinct entities.Narcissia trigonariavar.helenaeis placed in the synonymy ofN.trigonaria, andN.gracilis malpeloensisinto the synonymy ofN.gracilis. The dataset obtained in this work is by far the most complete acquired for the genusNarcissia.
The transdiagnostic origins of anxiety and depression during the pediatric period: Linking NIMH research domain criteria (RDoC) constructs to ecological systems
Authors: Doom Jenalee R. , Rozenman Michelle , Fox Kathryn R. , Phu Tiffany , Subar Anni R. , Seok Deborah , Rivera Kenia M.
Published: December 2021

In the last decade, an abundance of research has utilized the National Institute of Mental Health (NIMH) research domain criteria (RDoC) framework to examine mechanisms underlying anxiety and depression in youth. However, relatively little work has examined how these mechanistic intrapersonal processes intersect with context during childhood and adolescence. The current paper covers reviews and meta-analyses that have linked RDoC-relevant constructs to ecological systems in internalizing problems in youth. Specifically, cognitive, biological, and affective factors within the RDoC framework were examined. Based on these reviews and some of the original empirical research they cover, we highlight the integral role of ecological factors to the RDoC framework in predicting onset and maintenance of internalizing problems in youth. Specific recommendations are provided for researchers using the RDoC framework to inform future research integrating ecological systems and development. We advocate for future research and research funding to focus on better integration of the environment and development into the RDoC framework.
Translating RDoC to real-world impact in developmental psychopathology: A neurodevelopmental framework for application of mental health risk calculators
Authors: MacNeill Leigha A. , Allen Norrina B. , Poleon Roshaye B. , Vargas Teresa , Osborne K. Juston , Damme Katherine S. F. , Barch Deanna M. , Krogh-Jespersen Sheila , Nielsen Ashley N. , Norton Elizabeth S. , Smyser Christopher D. , Rogers Cynthia E. , Luby Joan L. , Mittal Vijay A. , Wakschlag Lauren S.
Published: December 2021

The National Institute of Mental Health's Research Domain Criteria (RDoC) framework has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally based tools for clinical decision making has limited the real-world impact of the RDoC. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between the RDoC multiple units of analysis and developmental science.
Sleep problems predict next-day suicidal thinking among adolescents: A multimodal real-time monitoring study following discharge from acute psychiatric care
Authors: Glenn Catherine R. , Kleiman Evan M. , Kearns Jaclyn C. , Boatman Anne E. , Conwell Yeates , Alpert-Gillis Linda J. , Pigeon Wilfred
Published: December 2021

Suicidal thoughts and behaviors (STBs) are major public health concerns among adolescents, and research is needed to identify how risk is conferred over the short term (hours and days). Sleep problems may be associated with elevated risk for STBs, but less is known about this link in youth over short time periods. The current study utilized a multimodal real-time monitoring approach to examine the association between sleep problems (via daily sleep diary and actigraphy) and next-day suicidal thinking in 48 adolescents with a history of STBs during the month following discharge from acute psychiatric care. Results indicated that specific indices of sleep problems assessed via sleep diary (i.e., greater sleep onset latency, nightmares, ruminative thoughts before sleep) predicted next-day suicidal thinking. These effects were significant even when daily sadness and baseline depression were included in the models. Moreover, several associations between daily-level sleep problems and next-day suicidal thinking were moderated by person-level measures of the construct. In contrast, sleep indices assessed objectively (via actigraphy) were either not related to suicidal thinking or were related in the opposite direction from hypothesized. Together, these findings provide some support for sleep problems as a short-term risk factor for suicidal thinking in high-risk adolescents.
Using development and psychopathology principles to inform the Research Domain Criteria (RDoC) framework
Authors: Conradt Elisabeth , Crowell Sheila E. , Cicchetti Dante
Published: December 2021

In 2010, the Research Domain Criteria (RDoC) were developed to advance our understanding of the pathophysiology of mental illness across multiple levels of analysis, ranging from cells to circuits to self-report instruments. Several conceptual RDoC-informed manuscripts have highlighted the importance of studying how developmental processes give rise to psychopathology. However, there are few empirical studies that integrate the RDoC framework with development and psychopathology principles. This special issue was developed to fill this empirical gap. In this introduction to the special issue, we describe how the developmental psychopathology field predates and informs the RDoC framework. We highlight three important ways in which developmental psychopathology and the RDoC framework can mutually inform one another, leading to novel discoveries to identify, prevent, and treat mental health problems across the life span.
Measuring the biological embedding of racial trauma among Black Americans utilizing the RDoC approach
Authors: Carter Sierra E. , Gibbons Frederick X. , Beach Steven R.H.
Published: December 2021

The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) initiative aims to understand the mechanisms influencing psychopathology through a dimensional approach. Limited research thus far has considered potential racial/ethnic differences in RDoC constructs that are influenced by developmental and contextual processes. A growing body of research has demonstrated that racial trauma is a pervasive chronic stressor that impacts the health of Black Americans across the life course. In this review article, we examine the ways that an RDOC framework could allow us to better understand the biological embedding of racial trauma among Black Americans. We also specifically examine the Negative Valence System domain of RDoC to explore how racial trauma is informed by and can help expand our understanding of this domain. We end the review by providing some additional research considerations and future research directives in the area of racial trauma that build on the RDoC initiative.
Between Dialogue and Denunciation: The World Council of Churches, Religious Freedom, and Human Rights during the Cold War
Authors: Bouwman Bastiaan
Published: December 2021

While the historiography on the religious Cold War has tended to focus on Christian anticommunism, the World Council of Churches (WCC) sought to transcend the Cold War while simultaneously advancing religious freedom in the Soviet Union. This article connects the WCC's ecclesiastical diplomacy to the wider story of human rights, from which religion has too often been excluded. The WCC's quest for Christian fellowship led it to integrate the Russian Orthodox Church into its membership, but this commitment generated tensions with the rise of Soviet dissidence. Moreover, the WCC's turn towards the left and the Third World contrasted with newly ascendant voices for human rights in the 1970s: Amnesty International's depoliticised liberalism, evangelical anticommunism, and the Vatican under John Paul II. Thus, the WCC, an early and prominent transnational voice for human rights, ran afoul of shifts in both the Cold War and the politics of protest.
Patient–physician conversations about life-sustaining treatment: Treatment preferences and participant assessments
Authors: Tuesen Lone Doris , Bülow Hans-Henrik , Ågård Anne Sophie , Strøm Sverre Maintz , Fromme Erik , Jensen Hanne Irene
Published: December 2021

Objective

In 2019, the Danish parliament issued legislation requiring Danish physicians to clarify and honor seriously ill patients’ treatment preferences. The American POLST (Physician Orders for Life-Sustaining Treatment) document could be a valuable model for this process. The aim of the study was to examine patients' preferences for life-sustaining treatment and participant assessment of a Danish POLST form.

Methods

The study is a prospective intervention based on a pilot-tested Danish POLST form. Participant assessments were examined using questionnaire surveys. Patients with serious illness and/or frailty from seven hospital wards, two general practitioners, and four nursing homes were included. The patients and their physicians completed the POLST form based on a process of shared decision-making.

Results

A total of 95 patients (aged 41–95) participated. Hereof, 88% declined cardiopulmonary resuscitation, 83% preferred limited medical interventions or comfort care, and 74% did not require artificial nutrition. The preferences were similar within age groups, genders, and locations, but with a tendency toward younger patients being more in favor of full treatment and nursing home residents being more in favor of cardiopulmonary resuscitation. Questionnaire response rates were 69% (66/95) for patients, 79% (22/28) for physicians, and 31% (9/29) for nurses. Hereof, the majority of patients, physicians, and nurses found that the POLST form was usable for conversations and decision-making about life-sustaining treatment to either a high or very high degree.

Significance of results

The majority of seriously ill patients did not want a resuscitation attempt and opted for selected treatments. The majority of participants found that the Danish POLST was usable for conversations and decisions about life-sustaining treatment to either a high or a very high degree, and that the POLST form facilitated an opportunity to openly discuss life-sustaining treatment.
The Politics of Women's Presence on High Courts: Bias and the Conditional Nature of Cultivating Legitimacy
Authors: Shortell Christopher , Valdini Melody E.
Published: December 2021

While we know that women's presence in the legislature positively impacts how citizens view the institution, little is known about the impact of women's presence on the legitimacy of high courts. We argue that despite differences in public expectations for courts, women's presence on the high court does impact citizen perceptions of legitimacy. However, this effect is dependent on both the level and the type of bias held by citizens. That is, when a person feels hostile bias toward women, the bias disrupts the potential legitimacy that the court could gain. On the other hand, we argue that benevolent sexism does not trigger any change in how citizens view the high court in a democracy. Using evidence from an experiment, we find that the presence of women on the high court has a strong positive impact on citizen perceptions of court legitimacy, though not among those with hostile gender bias.
The potentials of heresthetic and rhetoric in an open framing situation: theory and evidence from a survey experiment
Authors: Körösényi András , Patkós Veronika , Plesz Bendegúz , Susánszky Pál
Published: December 2021

To win a policy debate, political actors may apply two analytically distinct counterframing strategies, rhetoric and heresthetic. Rhetoric is when counterarguments are formulated in the original dimension of the debate, while heresthetic is using arguments in a different dimension compared to the original frame. Although both rhetoric and heresthetic are ubiquitous phenomena in the process of public opinion formation, there are no general rules to specify their efficacy. Drawing on a survey experiment carried out in Hungary in 2020 (N = 2000), this paper uncovers the factors determining the effect of the two strategies. Introducing a conceptual distinction between open and trade-off framing situations, the paper demonstrates that the structure of the situation matters. While heresthetic has a robust effect in trade-off framing situations, rhetoric may have a strong impact in open framing situations. Moreover, the effectiveness of counterframing depends on the party affiliation of respondents and the strength of their related attitudes.
Properties of Plasmoids Observed in Saturn's Dayside and Nightside Magnetodisc
Authors: Xu Y. , Guo R. L. , Yao Z. H. , Pan D. X. , Dunn W. R. , Ye S.‐Y. , Zhang B. , Sun Y. X. , Wei Y. , Coates A. J.
Published: December 2021

Plasmoid is a key structure for transferring magnetic flux and plasma in planetary magnetospheres. At Earth, plasmoids are key media which transfer energy and mass in the “Dungey Cycle.” For giant planets, plasmoids are primarily generated by the dynamic processes associated with “Vasyliunas cycle.” It is generally believed that planetary magnetotails are favorable for producing plasmoids. Nevertheless, recent studies reveal that magnetic field lines could be sufficiently stretched to allow magnetic reconnection in Saturn's dayside magnetodisc. In the study, we report direct observations of plasmoids in Saturn's dayside magnetodisc for the first time. Moreover, we perform a statistical investigation on the global plasmoid electron density distribution. The results show an inverse correlation between the nightside plasmoid electron density and local time, and the maximum plasmoid electron density around prenoon local time on the dayside. These results are consistent with the magnetospheric circulation picture associated with the “Vasyliunas cycle.”
Performance of Earth Troposphere Calibration Measurements With the Advanced Water Vapor Radiometer for the Juno Gravity Science Investigation
Authors: Buccino D. R. , Kahan D. S. , Parisi M. , Paik M. , Barbinis E. , Yang O. , Park R. S. , Tanner A. , Bryant S. , Jongeling A.
Published: December 2021

The performance of an atmospheric water vapor radio path delay measurement and correction is reported using observations of the Juno Spacecraft during gravity field mapping of Jupiter. The Juno Gravity Science instrument measures the Doppler shift on the radio signals between the Juno spacecraft and the Earth‐based observing stations of NASA's Deep Space Network (DSN) during times of closest approach to Jupiter in order to map Jupiter's gravity field. These Doppler measurements are affected by noise sources between the spacecraft and DSN which include charged particles plasma and Earth's troposphere. A pair of redundant Advanced Water Vapor Radiometers (AWVR) co‐located at the DSN's DSS‐25 antenna in Goldstone, CA measure the brightness temperatures at the 22.2, 23.8 and 31.4 GHz spectral lines for water vapor content in Earth's atmosphere. The measurements of water vapor content are reduced into a measurement of radio path delay, which provides high‐precision calibrations of tropospheric noise on the radio links. Analyses of AWVR measurements show that spacecraft tracking errors, after removing other measurable errors from charged particles, are reduced by 46% on average and by as much as 70%, depending on local weather conditions near the Goldstone site.
Advances in biomineralization-inspired materials for hard tissue repair
Authors: Tang Shuxian , Dong Zhiyun , Ke Xiang , Luo Jun , Li Jianshu
Published: December 2021

Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties, including the bones and teeth in vertebrates. The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues. In particular, the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization. Here, we review recent advances in biomineralization-inspired materials developed for hard tissue repair. Biomineralization-inspired materials are categorized into different types based on their specific applications, which include bone repair, dentin remineralization, and enamel remineralization. Finally, the advantages and limitations of these materials are summarized, and several perspectives on future directions are discussed.
Measuring adherence to antihypertensive medication using an objective test in older adults attending primary care: cross-sectional study
Authors: Sheppard James P. , Albasri Ali , Gupta Pankaj , Patel Prashanth , Khunti Kamlesh , Martin Una , McManus Richard J. , Hobbs F. D. Richard
Published: December 2021

Analysis of urine samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) has previously revealed high rates of non-adherence to antihypertensive medication. It is unclear whether these rates represent those in the general population. This study aimed to investigate whether it is feasible to collect urine samples in a primary care setting and analyse them using LC-MS/MS to detect non-adherence to antihypertensive medication. This study used a prospective, observational cohort design. Consecutive patients were recruited opportunistically from five general practices in UK primary care. They were aged ≥65 years with hypertension and had at least one antihypertensive prescription. Participants were asked to provide a urine sample for analysis of medication adherence. Samples were sent to a laboratory via post and analysed using LC-MS/MS. Predictors of adherence to medication were explored with multivariable logistic regression. Of 349 consecutive patients approached for the study, 214 (61.3%) gave informed consent and 191 (54.7%) provided a valid urine sample for analysis. Participants were aged 76.2 ± 6.6 years and taking a median of 2 antihypertensive medications (IQR 1–3). A total of 27/191 participants (14.2%) reported not taking all of their medications on the day of urine sample collection. However, LC-MS/MS analysis of samples revealed only 4/27 (9/191 in total; 4.7%) were non-adherent to some of their medications. Patients prescribed more antihypertensive medications were less likely to be adherent (OR 0.24, 95%CI 0.09–0.65). Biochemical testing for antihypertensive medication adherence is feasible in routine primary care, although non-adherence to medication is generally low, and therefore widespread testing is not indicated.
Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study
Authors: Chen Min , Tian Hongjun , Huang Guoyong , Fang Tao , Lin Xiaodong , Shan Jianmin , Cai Ziyao , Chen Gaungdong , Chen Suling , Chen Ce , Ping Jing , Cheng Langlang , Chen Chunmian , Zhu Jingjing , Zhao Feifei , Jiang Deguo , Liu Chuanxin , Huang Guangchuan , Lin Chongguang , Zhuo Chuanjun
Published: December 2021

Brain pathological features during manic/hypomanic and depressive episodes in the same patients with bipolar disorder (BPD) have not been described precisely. The study aimed to investigate depressive and manic-phase-specific brain neural activity patterns of BPD in the same murine model to provide information guiding investigation of the mechanism of phase switching and tailored prevention and treatment for patients with BPD. In vivo two-photon imaging was used to observe brain activity alterations in the depressive and manic phases in the same murine model of BPD. Two-photon imaging showed significantly reduced Ca2+ activity in temporal cortex pyramidal neurons in the depression phase in mice exposed to chronic unpredictable mild stress (CUMS), but not in the manic phase in mice exposed to CUMS and ketamine. Total integrated calcium values correlated significantly with immobility times. Brain Ca2+ hypoactivity was observed in the depression and manic phases in the same mice exposed to CUMS and ketamine relative to naïve controls. The novel object recognition preference ratio correlated negatively with the immobility time in the depression phase and the total distance traveled in the manic phase. With recognition of its limitations, this study revealed brain neural activity impairment indicating that intrinsic emotional network disturbance is a mechanism of BPD and that brain neural activity is associated with cognitive impairment in the depressive and manic phases of this disorder. These findings are consistent with those from macro-imaging studies of patients with BPD. The observed correlation of brain neural activity with the severity of depressive, but not manic, symptoms need to be investigated further.
“Real-life” data of the efficacy and safety of belantamab mafodotin in relapsed multiple myeloma—the Mayo Clinic experience
Authors: Vaxman I. , Abeykoon J. , Dispenzieri A. , Kumar S. K. , Buadi F. , Lacy M. Q. , Dingli D. , Hwa Y. , Fonder A. , Hobbs M. , Reeder C. , Sher T. , Hayman S. , Kourelis T. , Warsame R. , Muchtar E. , Leung N. , Go R. , Gonsalves W. , Siddiqui M. , Kyle R. A. , Rajkumar S. V. , Kristen McCullough , Kapoor P. , Gertz M. A.
Published: December 2021

Belantamab mafodotin is a highly selective targeted therapy for multiple myeloma. It targets the B cell maturation antigen (BCMA) on plasma cells and showed promising results in several randomized clinical trials. We report the outcomes of 36 patients treated at Mayo Clinic. Our cohort received a median of eight prior lines of therapy. Six patients received belantamab in combination with other medications (pomalidomide, cyclophosphamide, thalidomide), 13 patients (36%) were 70 years or older, two patients had a creatinine of >2.5 mg/dL, and one patient was on dialysis. All three patients with renal failure received full dose belantamab. Chimeric antigen receptor (CAR-T) therapy was used prior to belantamab in seven patients and none of them responded to belantamab therapy. The overall response rate (ORR) was 33% (CR 6%, VGPR 8%, PR 19%), like the ORR reported in the DREAMM-2 trial. Keratopathy developed in 16 patients (43%), grade 1 in six patients, grade 2 in seven patients, and grade 3 in three patients. Eight percent discontinued therapy due to keratopathy. The median PFS and OS was 2 months and 6.5 months, respectively.
Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
Authors: Martinez-Val Ana , Bekker-Jensen Dorte B. , Steigerwald Sophia , Koenig Claire , Østergaard Ole , Mehta Adi , Tran Trung , Sikorski Krzysztof , Torres-Vega Estefanía , Kwasniewicz Ewa , Brynjólfsdóttir Sólveig Hlín , Frankel Lisa B. , Kjøbsted Rasmus , Krogh Nicolai , Lundby Alicia , Bekker-Jensen Simon , Lund-Johansen Fridtjof , Olsen Jesper V.
Published: December 2021

Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry-based proteomics in combination with subcellular fractionation can provide comprehensive maps of spatio-temporal regulation of protein networks in cells, but involves laborious workflows that does not cover the phospho-proteome level. Here we present a high-throughput workflow based on sequential cell fractionation to profile the global proteome and phospho-proteome dynamics across six distinct subcellular fractions. We benchmark the workflow by studying spatio-temporal EGFR phospho-signaling dynamics in vitro in HeLa cells and in vivo in mouse tissues. Finally, we investigate the spatio-temporal stress signaling, revealing cellular relocation of ribosomal proteins in response to hypertonicity and muscle contraction. Proteomics data generated in this study can be explored through https://SpatialProteoDynamics.github.io.
Improving the alkali metal electrode/inorganic solid electrolyte contact via room-temperature ultrasound solid welding
Authors: Wang Xinxin , Chen Jingjing , Wang Dajian , Mao Zhiyong
Published: December 2021

The combination of alkali metal electrodes and solid-state electrolytes is considered a promising strategy to develop high-energy rechargeable batteries. However, the practical applications of these two components are hindered by the large interfacial resistance and growth of detrimental alkali metal depositions (e.g., dendrites) during cycling originated by the unsatisfactory electrode/solid electrolyte contact. To tackle these issues, we propose a room temperature ultrasound solid welding strategy to improve the contact between Na metal and Na3Zr2Si2PO12 (NZSP) inorganic solid electrolyte. Symmetrical Na|NZSP | Na cells assembled via ultrasonic welding show stable Na plating/stripping behavior at a current density of 0.2 mA cm−2 and a higher critical current density (i.e., 0.6 mA cm−2) and lower interfacial impedance than the symmetric cells assembled without the ultrasonic welding strategy. The beneficial effect of the ultrasound welding is also demonstrated in Na|NZSP | Na3V2(PO4)3 full coin cell configuration where 900 cycles at 0.1 mA cm−2 with a capacity retention of almost 90% can be achieved at room temperature.
Patterns of livestock depredation and Human–wildlife conflict in Misgar valley of Hunza, Pakistan
Authors: Bano Rubina , Khan Akbar , Mehmood Tahir , Abbas Saeed , Khan Muhammad Zafar , Shedayi Arshad Ali , Zaman Sher , Nawaz Muhammad Ali
Published: December 2021

Throughout the world, livestock predation by mammalian carnivores causes significant economic losses to poor farmers, and leads to human–wildlife conflicts. These conflicts result in a negative attitude towards carnivore conservation and often trigger retaliatory killing. In northern Pakistan, we investigated livestock depredation by large carnivores between 2014 and 2019, and subsequent Human–wildlife conflict, through questionnaire-based surveys (n = 100 households). We used a semi-structured questionnaire to collect data on livestock population, depredation patterns, predation count, and conservation approaches. We found a statistically significant increasing pattern of predation with influential factors such as age, gender, occupation, education of respondents, population of predators, threats index for predators and conservation efforts. Some 310 livestock heads with an average of 51 animals per year out of the total 9273 heads were killed by predators, and among them 168 (54%) were attributed to the wolf and 142 (45.8%) to snow leopard. Major threats to carnivores in the area included retaliatory killing, habitat destruction and climate change. Incentivization against depredation losses, guarded grazing and construction of predator-proof corral may reduce Human–wildlife conflict and both livelihood and predator can be safeguarded in the study area.
Disruptions to shared mental models from poor quality of service in collaborative virtual environments
Authors: Milef Nicholas , Ryason Adam , Qi Di , Alfred Samuel O. , Jackson Cullen D. , De Suvranu
Published: December 2021

Collaborative virtual environments are being used in various applications ranging from online games to complex team training scenarios. The key to the success of such environments is the ability of the participants to form a shared mental model of the collaborative task being performed. Poor quality of service can deteriorate user performance and quality of experience, leading to a disruption of this mental model. While the effects of quality of service have been analyzed for traditional desktop environments, these effects remain unclear in collaborative virtual environments during user-to-user interactions. Here, we analyze the role of latency and packet bursts, two common problems in collaborative applications, on both simulator perception and actual task performance in a collaborative fire-fighting simulator. This exploratory study indicates that large latencies have a significant (p < 0.05) impact on the quality of experience, but not task performance. In contrast, packet bursts have a much larger impact on both the quality of experience and performance. Additionally, the network role, such as whether a user is a client or server, showed a significant (p < 0.05) impact on task performance in conditions impaired by packet bursts.
Increased rates of dispersal of free-ranging cane toads (Rhinella marina) during their global invasion
Authors: Shine Richard , Alford Ross A. , Blennerhasset Ryan , Brown Gregory P. , DeVore Jayna L. , Ducatez Simon , Finnerty Patrick , Greenlees Matthew , Kaiser Shannon W. , McCann Samantha , Pettit Lachlan , Pizzatto Ligia , Schwarzkopf Lin , Ward-Fear Georgia , Phillips Benjamin L.
Published: December 2021

Invasions often accelerate through time, as dispersal-enhancing traits accumulate at the expanding range edge. How does the dispersal behaviour of individual organisms shift to increase rates of population spread? We collate data from 44 radio-tracking studies (in total, of 650 animals) of cane toads (Rhinella marina) to quantify distances moved per day, and the frequency of displacement in their native range (French Guiana) and two invaded areas (Hawai’i and Australia). We show that toads in their native-range, Hawai’i and eastern Australia are relatively sedentary, while toads dispersing across tropical Australia increased their daily distances travelled from 20 to 200 m per day. That increase reflects an increasing propensity to change diurnal retreat sites every day, as well as to move further during each nocturnal displacement. Daily changes in retreat site evolved earlier than did changes in distances moved per night, indicating a breakdown in philopatry before other movement behaviours were optimised to maximise dispersal.