bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel hydration assessment techniques employing thirst and a water intake challenge in healthy men
Authors: Armstrong Lawrence E. , Ganio Matthew S. , Klau Jennifer F. , Johnson Evan C. , Casa Douglas J. , Maresh Carl M.
Published: July 2013

Exploring novel hydration indices is important because no human biomarker has been shown to be incontrovertibly valid in all life situations. The present investigation was designed to identify inexpensive, nontechnical methods to use when self-assessing hydration status. This investigation evaluated the validity and efficacy of 2 novel techniques (i.e., thirst sensation and urine volume) to assess hydration state of 29 active men (mean ± SD; age, 23 ± 4 years; body mass, 76.02 ± 11.94 kg) at rest. Eight combinations of 4 water challenges (4.8, 9.3, 11.0, or 14 mL·kg−1) and 2 hydration states (mildly hypohydrated (HY), –2.0%; euhydrated (EU), –0.2% body mass) were employed. First, thirst was linearly related to body water loss, and ratings of thirst distinguished HY from EU (p < 0.001) subsequent to 19 h of controlled food and fluid intake. Second, measurements of urine volume 60 min after consuming a water bolus (11.0 or 14 mL·kg−1) were strongly and inversely correlated with entering hydration state, assessed by urine specific gravity (r2 = 0.76, p < 0.0001) and urine osmolality (r2 = 0.77, p < 0.0001). We concluded that healthy men can employ simple measurements of morning thirst sensation and urine volume to identify the presence of mild hypohydration and to guide fluid replacement. These 2 techniques are relevant because HY (–2% body mass) is the approximate threshold for the onset of thirst, reduced endurance exercise performance, and decrements of working memory and mood.
Pyroclastic kimberlite deposits from the Victor Northwest pipe (Ontario, Canada): the transition from phreatomagmatic to magmatic explosivity
Authors: van Straaten Bram I. , Kopylova M.G.
Published: July 2013

Magmas of all compositions, including kimberlites, may undergo both magmatic and phreatomagmatic fragmentation during emplacement. In this contribution we assess the extent of phreatomagmatism at different stages of the pipe formation for the Victor Northwest kimberlite (northern Ontario, Canada). Detailed drill core and petrographic observations of all volcanic facies within the pipe suggest emplacement in two volcanic cycles, each consisting of three repeated eruptive phases. Pyroclastic kimberlite formed at the start of both cycles is characterized by the presence of fine-grained, poorly sorted deposits containing broken olivine crystals, angular country rock fragments, accretionary lapilli, and variably vesicular irregular-shaped juvenile pyroclasts. All observations indicate these deposits formed by phreatomagmatism. Subsequent clastogenic coherent kimberlite deposits were formed as a result of Hawaiian fire-fountaining during the second phase of both cycles. These phases were followed by mass wasting into the partly filled crater. The evolution from phreatomagmatic to magmatic fragmentation is commonplace in volcanic systems, and our study provides the first indication that the evolution from a phreatomagmatic to magmatic eruption style is also present in kimberlite volcanoes, suggesting kimberlite volcanism is not significantly different from more common basaltic to rhyolitic systems. In addition, this research indicates that high fragmentation intensities recorded by the presence of broken olivines, accretionary lapilli, abundant (angular) country rock clasts, and retention of ash are important textural criteria for recognition of phreatomagmatic kimberlite deposits.
HIGH-ORDER LATTICE-BOLTZMANN EQUATIONS AND STENCILS FOR MULTIPHASE MODELS
Authors: MATTILA KEIJO K. , SIEBERT DIOGO N. , HEGELE LUIZ A. , PHILIPPI PAULO C.
Published: July 2013

The lattice Boltzmann (LB) method, based on mesoscopic modeling of transport phenomena, appears to be an attractive alternative for the simulation of complex fluid flows. Examples of such complex dynamics are multiphase and multicomponent flows for which several LB models have already been proposed. However, due to theoretical or numerical reasons, some of these models may require application of high-order lattice-Boltzmann equations (LBEs) and stencils. Here, we will present a derivation of LBEs from the discrete-velocity Boltzmann equation (DVBE). By using the method of characteristics, high-order accurate equations are conveniently formulated with standard numerical methods for ordinary differential equations (ODEs). In particular, we will derive implicit LB schemes due to their stability properties. A simple algorithm is presented which enables implementation of the implicit schemes without resorting to, e.g. change of variables. Finally, some numerical experiments with high-order equations and stencils together with two specific multiphase models are presented.
Cardio-Protection by Ginkgo biloba Extract 50 in Rats with Acute Myocardial Infarction is Related to Na+–Ca2+ Exchanger
Authors: Liu Ai-Hua , Bao Yi-Min , Wang Xing-Yu , Zhang Zhi-Xiong
Published: July 2013

Ginkgo biloba has been used for medical purposes for centuries in traditional Chinese medicine. Ginkgo biloba extract 50 (GBE50) is a new standardized GBE product that matches the standardized German product as EGb761. This paper is aimed at studying the cardio-protection effects of GBE50 Salvia miltiorrhiza on myocardial function, area at risk, myocardial ultra-structure, and expression of calcium handling proteins in rat ischemic myocardium. Myocardium ischemia was induced by the left anterior descending (LAD) coronary artery occlusion and myocardial function was recorded by a transducer advanced into the left ventricle on a computer system. In vitro myocardial infarction was measured by 2,3,5-triphenyltetrazolium chloride (TTC) and Evans blue staining of heart sections. Morphological change was evaluated by electric microscopy and Western blotting was used for protein expression. Hemodynamic experiments in vivo showed that postischemic cardiac contractile function was reduced in ischemic rats. Salvia miltiorrhiza (7.5 g/kg/d×7) and Ginkgo biloba extract 50 (GBE50) (100 mg/kg/d×7) improved post-schemic cardiac diastolic dysfunction while not affecting the systolic function. In hearts of GBE50 group and Salvia miltiorrhiza (SM) group, the area at risk was significantly reduced and myocardial structure was better-preserved. Moreover, Na +– Ca 2+ exchanger (NCX) expression increase and sarcoplasmic reticulum Ca 2+– ATPase 2 (SERCA2), LTCC, and ryanodine receptor 2 (RyR2) expression decreases were smaller than those in ischemia group. There was a significant difference between the GBE50 and ischemia group in NCX expression. GBE50 could improve recovery in contractile function and prevent myocardium from ischemia damage, which may be caused by attenuating the abnormal expression of NCX.
Intravenous Administration of Tetramethylpyrazine Reduces Intestinal Ischemia-Reperfusion Injury in Rats
Authors: Tóth Štefan , Pekárová Tímea , Varga Ján , Tóth Štefan , Tomečková Vladimíra , Gál Peter , Veselá Jarmila , Guzy Juraj
Published: July 2013

Intestinal ischemia-reperfusion injury (IIRI) is a life-threatening condition requiring prompt medical intervention. Tetramethylpyrazine (TMP) is a biologically active alkaloid isolated from Ligusticum wallichii. Previously, it was shown that TMP causes vasodilatation and inhibition of platelet aggregation as well as exhibits significant antioxidant effects. Therefore, the aim of the present study was to evaluate possible therapeutic effects of TMP in the prevention of IIRI. Wistar rats (n = 80) were randomly divided into eight experimental groups and subjected to a 1 h occlusion of cranial mesenteric artery followed by 0, 1, 12, and 24 h period of reperfusion. Thirty minutes before the IIRI animals received either TMP (30 mg/kg, i.v.) or identical volume of saline. In addition, a control group of 10 animals was not exposed to IIRI. Intestine morphology was evaluated by using histopathological injury index examination (HII), goblet and Paneth cells quantification as well as by applying immunofluorescent methods such as InSitu TUNEL and caspase-3 positivity assessment. Here we showed that preconditioning with TMP prior IIRI decreases the grade of injury. Significant reduction of HII was detected in TMP pretreated groups after 0, 1, and 12 h of reperfusion where injury reduction up to 75% was found. Lower histopathological damage in preconditioned groups was accompanied with increased number of secretory epithelial cells and decreased number of apoptotic cells. These results demonstrate the protective effect of TMP on the small intestine mucosa, suggesting administration of TMP as a molecule for pharmacological intervention against IIRI.
Effect of Arecoline on Regeneration of Injured Peripheral Nerves
Authors: Lee Sheng-Chi , Tsai Chin-Chuan , Yao Chun-Hsu , Hsu Yuan-Man , Chen Yueh-Sheng , Wu Ming-Chang
Published: July 2013

The present study provides in vitro and in vivo evaluation of arecoline on peripheral nerve regeneration. In the in vitro study, we found that arecoline at 50 μg/ml could significantly promote the survival and outgrowth of cultured Schwann cells as compared to the controls treated with culture medium only. In the in vivo study, we evaluated peripheral nerve regeneration across a 10-mm gap in the sciatic nerve of the rat, using a silicone rubber nerve chamber filled with the arecoline solution. In the control group, the chambers were filled with normal saline only. At the end of the fourth week, morphometric data revealed that the arecoline-treated group at 5 μg/ml significantly increased the number and the density of myelinated axons as compared to the controls. Immunohistochemical staining in the arecoline-treated animals at 5 μg/ml also showed their neural cells in the L4 and L5 dorsal root ganglia ipsilateral to the injury were strongly retrograde-labeled with fluorogold and lamina I–II regions in the dorsal horn ipsilateral to the injury were significantly calcitonin gene-related peptide-immunolabeled compared with the controls. In addition, we found that the number of macrophages recruited in the distal sciatic nerve was increased as the concentration of arecoline was increased. Electrophysiological measurements showed the arecoline-treated groups at 5 and 50 μg/ml had a relatively larger nerve conductive velocity of the evoked muscle action potentials compared to the controls. These results indicate that arecoline could stimulate local inflammatory conditions, improving the recovery of a severe peripheral nerve injury.
Carpesium macrocephalum Attenuates Lipopolysaccharide-Induced Inflammation in Macrophages by Regulating the NF-κB/IκB-α, Akt, and STAT Signaling Pathways
Authors: Koppula Sushruta , Kim Wan-Jae , Jiang Jun , Shim Do-Wan , Oh Na-Hyun , Kim Tack-Joong , Kang Tae-Bong , Lee Kwang-Ho
Published: July 2013

Carpesium macrocephalum (CM) Fr. et Sav. (Compositae) has been used in Chinese folk medicine as an analgesic, hemostatic, antipyretic, and to suppress inflammatory conditions. In the present study we aimed to provide scientific evidence for the anti-inflammatory properties of CM extract and evaluate the intrinsic mechanisms involved in both in vitro and in vivo experimental models. In in vitro findings, CM significantly inhibited the LPS-stimulated release of proinflammatory mediators such as nitric oxide, tumor necrosis factor-alpha, prostaglandin E2, and interleukin-6 in RAW264.7 macrophages in a concentration-dependent fashion. The attenuation of inflammatory responses in LPS-activated RAW264.7 cells by CM was closely associated with the suppression of nuclear factor-kappa B (NF-κB) phosphorylation, IκB-α degradation, and phosphorylation of Akt. CM treatment also attenuated the phosphorylation of STAT through TRIF dependent pathways in LPS-activated RAW264.7 cells. In vivo studies revealed that CM extract concentration dependently suppressed the acetic acid-induced vascular permeability in mice. Considering the data obtained regulation of multiple signaling mechanisms involving TRIF and Akt/NF-κB pathways might be responsible for the potent anti-inflammatory action of CM, substantiating its traditional use in inflammatory diseases.
Anti-fatigue Activity of Hovenia dulcis on a Swimming Mouse Model through the Inhibition of Stress Hormone Expression and Antioxidation
Authors: Na Chun-Soo , Yoon Sun Young , Kim Jin Beom , Na Dae-Seung , Dong Mi-Sook , Lee Moo-Yeol , Hong Cheol Yi
Published: July 2013

Hovenia dulcis (H. dulcis) Thunb., which is distributed in Korea, China, and Japan, has been known to show hepatoprotective and free radical scavenging effects and enhance physical activity. Therefore, the objectives of this present study were to determine the anti-fatigue activity of hot-water extract from H. dulcis peduncle, and to find the reason why H. dulcis extract (HDE)-ingested mice had enhanced physical activity against swimming performance. The mice orally administrated with HDE (HDE-mice) dramatically enhanced their swimming time compared to the control mice. HDE significantly decreased serum levels of stress hormones, such as cortisol and adrenocorticotropic hormone (ACTH) in mice. The levels of thiobarbituric acid reactive substances (TBARS) were dramatically decreased in gastrocnemius muscle from both 100 mg/kg of HDE (LHDE) and 200 mg/kg of HDE (HHDE)-ingested mice compared to the control mice. The liver activities of superoxide dismutase (SOD) were significantly increased in HHDE-mice with increasing tendency in LHDE-mice. In addition, HHDE-mice significantly decreased the levels of blood glucose, total cholesterol (T-Chol), and triglyceride (TG). These results suggest that HDE had a significant anti-fatigue effect via its anti-stress and antioxidant activities, and thereby enhanced physical activity in swimming performance.
HOLOGRAPHIC SUPERCONDUCTORS WITH WEYL CORRECTIONS VIA GAUGE/GRAVITY DUALITY
Authors: MOMENI D. , MYRZAKULOV R. , RAZA M.
Published: July 2013

In this paper, we analytically investigate the properties of Weyl's corrected p-wave holographic superconductors by the matching method. The relation between the critical temperature Tc and the charge density ρ has been obtained as Tc ∝ ρ⅓ and the dependence of the expectation value of the condensation operator on the temperature has been found analytically in the form [Formula: see text]. The critical exponent of the condensation also comes out to be ½, which is the universal value in the mean field theory and which has nothing to do with the Weyl coupling γ. Our results are in very good agreement with the existing numerical results and have been obtained using the variational method.
IRREPARABLE ROTATOR CUFF TEAR; A SURGICAL DILEMMA
Authors: Kumar Nishikant , Mehtani Anil
Published: July 2013

Rotator cuff tear are common injuries in modern day orthopedic practice. Irreparable rotator cuff tear are those massive tear which cannot be repaired primarily. Their management depends on several factors like symptoms, age of patient, location of tear and examination findings. However, most chronic rotator cuff tear especially in older age group can be treated conservatively, when shoulder has reasonably good range of movement.
ON CLASS-PRESERVING COLEMAN AUTOMORPHISMS OF FINITE SEPARABLE GROUPS
Authors: HAI JINKE , LI ZHENGXING
Published: July 2013

Let G be a finite separable group. It is shown that under some conditions class-preserving Coleman automorphisms of 2-power order of G are inner. Interest in such automorphisms arose from the study of the normalizer problem for integral group rings. Our theorems generalize some well-known results.
POLYNOMIALS THAT KILL EACH ELEMENT OF A FINITE RING
Authors: WERNER NICHOLAS J.
Published: July 2013

Given a finite (associative, unital) ring R, let K(R) denote the set of polynomials in R[x] that send each element of R to 0 under evaluation. We study K(R) and its elements. We conjecture that K(R) is a two-sided ideal of R[x] for any finite ring R, and prove the conjecture for several classes of finite rings (including commutative rings, semisimple rings, local rings, and all finite rings of odd order). We also examine a connection to sets of integer-valued polynomials.
SYNTHESES OF NANOSTRUCTURE BUNDLES BASED ON SEMICONDUCTING METAL SILICIDES
Authors: LI WEN , ISHIKAWA DAISUKE , TATSUOKA HIROKAZU
Published: July 2013

A variety of nanostructure bundles and arrays based on semiconducting metal silicides have been synthesized using abundant and non-toxic starting materials. Three types of fabrication techniques of the nanostructure bundles or arrays, including direct growth, template synthesis using natural nanostructured materials and template synthesis using artificially fabricated nanostructured materials are demonstrated. CrSi 2 nanowire bundles were directly grown by the exposure of Si substrates to CrCl 2 vapor at atmospheric pressure. A hexagonal MoSi 2 nanosheet, Mg 2 Si / MgO composite nanowire and Mg 2 Si nanowire bundles and MnSi 1.7 nanowire array were synthesized using a MoS 2 layered material, a SiO x nanofiber bundle, a Si nanowire array, and a Si nanowire array as the templates, respectively. Additionally, the fabrication phenomenon and structural properties of the nanostructured semiconducting metal silicides were investigated. These reactions provided the low-cost and controllable synthetic techniques to synthesize large scale and one-dimensional semiconducting metal silicides for thermoelectric applications.
Fluvial architecture and connectivity of the Williams Fork Formation: use of outcrop analogues for stratigraphic characterization and reservoir modelling
Authors: Pranter Matthew J. , Hewlett Alicia C. , Cole Rex D. , Wang Huabing , Gilman James
Published: July 2013

This study addresses the stratigraphic architecture and connectivity of fluvial sandstones of the Williams Fork Formation through outcrop analysis, and static and dynamic modelling of equivalent reservoirs in the Piceance Basin, Colorado. The Williams Fork Formation is a succession of fluvial channel sandstones, crevasse splays, floodplain mudstones and paludal coals that were deposited by meandering- and braided-river systems within coastal- and alluvial-plain settings.

Three-dimensional (3D) static and dynamic reservoir models that are constrained to both outcrop-derived and subsurface data show how static connectivity is sensitive to sandstone-body type and width, and varies with net to gross ratio. Connectivity analyses of 3D outcrop-based architectural-element models show how relatively wide sandstone bodies enhance connectivity. At Mamm Creek Field, connectivity of sandstones that are pay within the middle Williams Fork Formation is 12–18% higher than for the lower Williams Fork Formation. For highly constrained 3D object-based models of architectural elements, connectivity is only 4% higher when crevasse splays are included as reservoir-quality sandstones. Dynamic simulation results also suggest that the best history match is possible by considering only point bars and channel bars (reservoir-quality sandstones) as pay. Additional research is necessary to determine the impact of crevasse splays on reservoir connectivity.
Trading obliviousness for modularity with cooperative aspect-oriented programming
Authors: Hoffman Kevin , Eugster Patrick
Published: July 2013

The potential of aspect-oriented programming to adequately capture crosscutting concerns has yet to be fully realized. For example, authors have detailed significant challenges in creating reusable aspect component libraries. One proposed solution is to introduce Explicit Join Points (EJPs) to increase modularity by reducing obliviousness, enabling a
Cooperative
Aspect-Oriented Programming (Co-AOP) methodology where base code and aspects synergistically collaborate.

This article explores the trade-offs between obliviousness and modularity. We briefly introduce EJPs and Co-AOP, and hypothesize how to balance obliviousness and modularity using Co-AOP. We build upon a prior empirical study to refactor three real-life Java applications to implement the exception handling concern using three distinct strategies: (1) using fully oblivious aspects in AspectJ, (2) using EJPs in a fully explicit fashion, and (3) using EJPs while following the Co-AOP methodology. We study other crosscutting concerns by refactoring a fourth application, JHotDraw. The differences in terms of common code metrics are analyzed, and the impact on modularity is assessed using design structure matrices. Results indicate that the Co-AOP methodology can in many cases significantly improve code quality attributes versus fully oblivious or fully explicit approaches. We conclude with guiding principles on the proper use of EJPs within the Co-AOP methodology.
LINQits
Authors: Chung Eric S. , Davis John D. , Lee Jaewon
Published: July 2013

We present LINQits, a flexible hardware template that can be mapped onto programmable logic or ASICs in a heterogeneous system-on-chip for a mobile device or server. Unlike fixed-function accelerators, LINQits accelerates a domain-specific query language called LINQ. LINQits does not provide coverage for all possible applications---however, existing applications (re-)written with LINQ in mind benefit extensively from hardware acceleration. Furthermore, the LINQits framework offers a graceful and transparent migration path from software to hardware.

LINQits is prototyped on a 2W heterogeneous SoC called the ZYNQ processor, which combines dual ARM A9 processors with an FPGA on a single die in 28nm silicon technology. Our physical measurements show that LINQits improves energy efficiency by 8.9 to 30.6 times and performance by 10.7 to 38.1 times compared to optimized, multithreaded C programs running on conventional ARM A9 processors.
T-Type Ca2+Channels in Normal and Abnormal Brain Functions
Authors: Cheong Eunji , Shin Hee-Sup
Published: July 2013

Low-voltage-activated T-type Ca2+channels are widely expressed in various types of neurons. Once deinactivated by hyperpolarization, T-type channels are ready to be activated by a small depolarization near the resting membrane potential and, therefore, are optimal for regulating the excitability and electroresponsiveness of neurons under physiological conditions near resting states. Ca2+influx through T-type channels engenders low-threshold Ca2+spikes, which in turn trigger a burst of action potentials. Low-threshold burst firing has been implicated in the synchronization of the thalamocortical circuit during sleep and in absence seizures. It also has been suggested that T-type channels play an important role in pain signal transmission, based on their abundant expression in pain-processing pathways in peripheral and central neurons. In this review, we will describe studies on the role of T-type Ca2+channels in the physiological as well as pathological generation of brain rhythms in sleep, absence epilepsy, and pain signal transmission. Recent advances in studies of T-type channels in the control of cognition will also be briefly discussed.
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Authors: Balla Tamas
Published: July 2013

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they control almost all aspects of a cell's life and death. These lipids gained tremendous research interest as plasma membrane signaling molecules when discovered in the 1970s and 1980s. Research in the last 15 years has added a wide range of biological processes regulated by PIs, turning these lipids into one of the most universal signaling entities in eukaryotic cells. PIs control organelle biology by regulating vesicular trafficking, but they also modulate lipid distribution and metabolism via their close relationship with lipid transfer proteins. PIs regulate ion channels, pumps, and transporters and control both endocytic and exocytic processes. The nuclear phosphoinositides have grown from being an epiphenomenon to a research area of its own. As expected from such pleiotropic regulators, derangements of phosphoinositide metabolism are responsible for a number of human diseases ranging from rare genetic disorders to the most common ones such as cancer, obesity, and diabetes. Moreover, it is increasingly evident that a number of infectious agents hijack the PI regulatory systems of host cells for their intracellular movements, replication, and assembly. As a result, PI converting enzymes began to be noticed by pharmaceutical companies as potential therapeutic targets. This review is an attempt to give an overview of this enormous research field focusing on major developments in diverse areas of basic science linked to cellular physiology and disease.
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
Authors: Iskander Kendra N. , Osuchowski Marcin F. , Stearns-Kurosawa Deborah J. , Kurosawa Shinichiro , Stepien David , Valentine Catherine , Remick Daniel G.
Published: July 2013

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes substantial human morbidity resulting in hundreds of thousands of deaths each year. Despite decades of intense research, the basic mechanisms still remain elusive. In either experimental animal models of sepsis or human patients, there are substantial physiological changes, many of which may result in subsequent organ injury. Variations in age, gender, and medical comorbidities including diabetes and renal failure create additional complexity that influence the outcomes in septic patients. Specific system-based alterations, such as the coagulopathy observed in sepsis, offer both potential insight and possible therapeutic targets. Intracellular stress induces changes in the endoplasmic reticulum yielding misfolded proteins that contribute to the underlying pathophysiological changes. With these multiple changes it is difficult to precisely classify an individual's response in sepsis as proinflammatory or immunosuppressed. This heterogeneity also may explain why most therapeutic interventions have not improved survival. Given the complexity of sepsis, biomarkers and mathematical models offer potential guidance once they have been carefully validated. This review discusses each of these important factors to provide a framework for understanding the complex and current challenges of managing the septic patient. Clinical trial failures and the therapeutic interventions that have proven successful are also discussed.
Vagal Blocking Improves Glycemic Control and Elevated Blood Pressure in Obese Subjects with Type 2 Diabetes Mellitus
Authors: Shikora S. , Toouli J. , Herrera M. F. , Kulseng B. , Zulewski H. , Brancatisano R. , Kow L. , Pantoja J. P. , Johnsen G. , Brancatisano A. , Tweden K. S. , Knudson M. B. , Billington C. J.
Published: July 2013

Background. An active device that downregulates abdominal vagal signalling has resulted in significant weight loss in feasibility studies.Objective. To prospectively evaluate the effect of intermittent vagal blocking (VBLOC) on weight loss, glycemic control, and blood pressure (BP) in obese subjects with DM2.Methods. Twenty-eight subjects were implanted with a VBLOC device (Maestro Rechargeable System) at 5 centers in an open-label study. Effects on weight loss, HbA1c, fasting blood glucose, and BP were evaluated at 1 week to 12 months.Results. 26 subjects (17 females/9 males,51±2years, BMI37±1 kg/m2, mean ± SEM) completed 12 months followup. One serious adverse event (pain at implant site) was easily resolved. At 1 week and 12 months, mean excess weight loss percentages (% EWL) were9±1% and25±4% (P<0.0001), and HbA1cdeclined by0.3±0.1% and1.0±0.2% (P=0.02, baseline7.8±0.2%). In DM2 subjects with elevated BP (n=15), mean arterial pressure reduced by7±3 mmHg and8±3 mmHg (P=0.04, baseline100 ± 2 mmHg) at 1 week and 12 months. All subjects MAP decreased by3 ± 2 mmHg (baseline95 ± 2 mmHg) at 12 months.Conclusions. VBLOC was safe in obese DM2 subjects and associated with meaningful weight loss, early and sustained improvements in HbA1c, and reductions in BP in hypertensive DM2 subjects. This trial is registered with ClinicalTrials.govNCT00555958.
Dietary Intake as a Link between Obesity, Systemic Inflammation, and the Assumption of Multiple Cardiovascular and Antidiabetic Drugs in Renal Transplant Recipients
Authors: Guida Bruna , Cataldi Mauro , Maresca Immacolata Daniela , Germanò Roberta , Trio Rossella , Nastasi Anna Maria , Federico Stefano , Memoli Andrea , Apicella Luca , Memoli Bruno , Sabbatini Massimo
Published: July 2013

We evaluated dietary intake and nutritional-inflammation status in ninety-six renal transplant recipients, years after transplantation. Patients were classified as normoweight (NW), overweight (OW), and obese (OB), if their body mass index was between 18.5 and 24.9, 25.0 and 29.9, and ≥30 kg/m2, respectively. Food composition tables were used to estimate nutrient intakes. The values obtained were compared with those recommended in current nutritional guidelines. 52% of the patients were NW, 29% were OW, and 19% were OB. Total energy, fat, and dietary n-6 PUFAs intake was higher in OB than in NW. IL-6 and hs-CRP were higher in OB than in NW. The prevalence of multidrug regimen was higher in OB. In all patients, total energy, protein, saturated fatty acids, and sodium intake were higher than guideline recommendations. On the contrary, the intake of unsaturated and n-6 and n-3 polyunsaturated fatty acids and fiber was lower than recommended. In conclusion, the prevalence of obesity was high in our patients, and it was associated with inflammation and the assumption of multiple cardiovascular and antidiabetic drugs. Dietary intake did not meet nutritional recommendations in all patients, especially in obese ones, highlighting the need of a long-term nutritional support in renal transplant recipients.
Modeling of Random Delays in Networked Control Systems
Authors: Ge Yuan , Chen Qigong , Jiang Ming , Huang Yiqing
Published: July 2013

In networked control systems (NCSs), the presence of communication networks in control loops causes many imperfections such as random delays, packet losses, multipacket transmission, and packet disordering. In fact, random delays are usually the most important problems and challenges in NCSs because, to some extent, other problems are often caused by random delays. In order to compensate for random delays which may lead to performance degradation and instability of NCSs, it is necessary to establish the mathematical model of random delays before compensation. In this paper, four major delay models are surveyed including constant delay model, mutually independent stochastic delay model, Markov chain model, and hidden Markov model. In each delay model, some promising compensation methods of delays are also addressed.
Geopolymer Binders: A Need for Future Concrete Construction
Authors: Srinivasan K. , Sivakumar A.
Published: July 2013

Applications of polymer based binder material can be an ideal choice in civil infrastructural applications since the conventional cement production is highly energy intensive. Moreover, it also consumes significant amount of natural resources for the large-scale production in order to meet the global infrastructure developments. On the other hand the usage of cement concrete is on the increase and necessitates looking for an alternative binder to make concrete. Geopolymer based cementitious binder was one of the recent research findings in the emerging technologies. The present study is aimed at providing a comprehensive review on the various production processes involved in the development of a geopolymer binder. More studies in the recent past showed a major thrust for wider applications of geopolymer binder towards a cost economic construction practice. This also envisages the reduction of global warming due to carbon dioxide emissions from cement plants.
Selective Cu(II) Adsorption from Aqueous Solutions Including Cu(II), Co(II), and Ni(II) by Modified Acrylic Acid Grafted PET Film
Authors: Rahman Nazia , Sato Nobuhiro , Yoshioka Satoru , Sugiyama Masaaki , Okabe Hirotaka , Hara Kazuhiro
Published: July 2013

Acrylic acid (AAc) grafted polyethylene terephthalate (PET) films were prepared by γ irradiation. The graft films showed little metal ion adsorption due to compact structure of the graft chains as shown by the scanning electron microscopy (SEM) images which restricted the access of metal ions to the functional groups. Therefore, the graft films were modified with KOH treatment for expansion of the graft chains to facilitate the access of metal ions to the functional groups. The modified films were used to study the selective Cu2+ adsorption from aqueous solution containing Cu2+, Co2+, and Ni2+. Langmuir and Freundlich isotherm models were used for interpretation of selective equilibrium adsorption data and Langmuir model showed better fitting with experimental data. Again pseudo-first-order and pseudo-second-order equations were used for interpretation of selective kinetic adsorption data and pseudo-second-order equation showed better prediction of experimental data. The adsorbent film showed high selectivity towards Cu2+ in presence of Cu2+, Co2+, and Ni2+ in the pH range of 1.5 to 4.5. Desorption and reuse of the adsorbent film were also studied which indicated that the film can be used repeatedly for selective Cu2+ sorption from aqueous solution.
Malfunctioning Plastic Biliary Endoprosthesis: Percutaneous Transhepatic Balloon Pulling Technique
Authors: Rossi Umberto G. , Rigamonti Paolo , Cariati Maurizio
Published: July 2013

Percutaneous transhepatic removal techniques for malfunctioning plastic biliary endoprosthesis are considered safe and efficient second-line strategies, when endoscopic procedures are not feasible. We describe the percutaneous transhepatic balloon pulling technique in a patient with an unresectable malignant hilar cholangiocarcinoma.
Repetitive Breech Presentations at Term
Authors: Zubor Pavol , Zigo Imrich , Sivakova Jana , Moricova Petra , Kapustova Ivana , Krivus Stefan , Danko Jan
Published: July 2013

The authors present a case of 38-year-old laboring woman with four-time repetitive breech presentation of the fetus at term. This rare condition affects the mode of delivery and represents serious obstetrical problem as it is associated with increased perinatal morbidity or mortality. The authors give details on risk factors for breech presentation, its diagnosis, and the discussion points on possible causes leading to repetitive breeches in laboring women.
Treatment of Uterine Myoma with 2.5 or 5 mg Mifepristone Daily during 3 Months with 9 Months Posttreatment Followup: Randomized Clinical Trial
Authors: Carbonell Josep Lluis , Acosta Rita , Pérez Yasmirian , Garcés Roberto , Sánchez Carlos , Tomasi Giuseppe
Published: July 2013

Objectives. To evaluate the efficacy, safety, and quality of life by using 2.5 and mifepristone 5 mg daily doses to treat uterine fibroids over 3 months with a 9-month followup period. Design. Randomized clinical trial. Place. “Eusebio Hernández” Hospital, Havana, Cuba. Subjects. 220 women with symptomatic uterine fibroids. Treatment. One-half (2.5 mg) or one-whole 5 mg mifepristone tablet. Variables to Evaluate Efficacy. Changes in fibroid and uterine volumes, in symptomatic prevalence and intensity, and in quality of life. Results. After 3-month treatment, fibroid volume decreased by 27.9% (CI 95% 20–35) and 45.5% (CI 95% 37–62), in the 2.5 and 5 mg groups, respectively, P=0.003. There was no difference in the prevalence of symptoms at the end of treatment, unlike after 6- and 9-month followup when there was a difference. Amenorrhea was significantly higher in the 5 mg group, P=0.001. There were no significant differences in mifepristone side effects between the groups. Both groups displayed a similar improvement in quality of life. Conclusions. The 2.5 mg dosage resulted in a lesser reduction in fibroid size but a similar improvement in quality of life when compared to the 5 mg dose. This trial is registered with ClinicalTrials.gov NCT01786226.
The Immune Interplay between the Host and the Pathogen inAspergillus fumigatusLung Infection
Authors: Sales-Campos Helioswilton , Tonani Ludmilla , Cardoso Cristina Ribeiro Barros , Kress Márcia Regina Von Zeska
Published: July 2013

The interplay betweenAspergillus fumigatusand the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors ofA. fumigatusare related to the fungus biological characteristics, for example, structure, ability to grow and adapt to high temperatures and stress conditions, besides capability of evading the immune system and causing damage to the host. In this context, the fungus recognition by the host innate immunity occurs when the pathogen disrupts the natural and chemical barriers followed by the activation of acquired immunity. It seems clear that a Th1 response has a protective role, whereas Th2 reactions are often associated with higher fungal burden, and Th17 response is still controversial. Furthermore, a fine regulation of the effector immunity is required to avoid excessive tissue damage associated with fungal clearance, and this role could be attributed to regulatory T cells. Finally, in this work we reviewed the aspects involved in the complex interplay between the host immune response and the pathogen virulence factors, highlighting the immunological issues and the importance of its better understanding to the development of novel therapeutic approaches for invasive lung aspergillosis.
Application of Simulation Methods for Evaluating the Sea Waterways Traffic Organisation
Authors: Blokus-Roszkowska Agnieszka , Smolarek Leszek
Published: July 2013

Maritime transport is of great importance as it is the basis of international trade. Shipping is a global industry and highly complex business. Further safety development at sea is determined by the growth of maritime traffic intensity. Therefore, new ideas and technologies are needed to optimize the sea transport system. In the paper, the cellular automaton model is suggested to describe traffic flow at grade roundabout and simple crossing. Not only the cell state but also neighborhood as well is defined for presented cellular automaton. The model, describing vessels motion, takes into account vessel’s type, speed and length, vessel’s behavior and maneuverability, lane status, and flow density. It provides the basis for simulation. Two types of traffic schemes, namely, roundabout and simple routes crossing, are considered. Some results of simulation, including ships safety prediction, illustrate possible applications for evaluation of maritime traffic organization. Final conclusion and remarks outline further work development.
Antimalarial Activity ofCocos nuciferaHusk Fibre: Further Studies
Authors: Adebayo J. O. , Balogun E. A. , Malomo S. O. , Soladoye A. O. , Olatunji L. A. , Kolawole O. M. , Oguntoye O. S. , Babatunde A. S. , Akinola O. B. , Aguiar A. C. C. , Andrade I. M. , Souza N. B. , Krettli A. U.
Published: July 2013

In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties ofCocos nuciferawere evaluatedin vitro. The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25–500 mg/kg body weight) using various organ function indices. The results revealed that WAT ethyl acetate extract fraction (WATEAEF) contained alkaloids, tannins, and flavonoids and was active againstPlasmodium falciparumW2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was activein vivoagainstPlasmodium bergheiNK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter (P>0.05) function indices of the liver and cardiovascular system at all doses administered but significantly increased (P<0.05) plasma creatinine concentration at 250 and 500 mg/Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.
Effect of Seed Size and Pretreatment Methods on Germination of Albizia lebbeck
Authors: Missanjo Edward , Maya Chikumbutso , Kapira Dackious , Banda Hannah , Kamanga-Thole Gift
Published: July 2013

Albizia lebbeck is a multipurpose tree species prioritised for conservation in Malawi. The different plant parts are used in traditional medicine to treat different diseases. However, the seeds are dormant, and the tree species remain undomesticated. A study was conducted to evaluate the effect of seed size and presowing on the germination of Albizia lebbeck in a nursery. Seeds were grouped into four categories in regard to their length, small (≤0.5 cm), medium ( cm), large (≥0.8 cm), and mixture of small, medium, and large seeds. The seeds were subjected to five main seed pretreatment methods, namely, soaking in sulphuric acid for 2 minutes, nicking, soaking in hot water for 5 minutes, soaking in cold water for 24 hours, and control where seeds were sown without any treatment. The results indicate that combination of nicking and large seeds produced the highest (100%) germination. Hot water treatment was effective in large seeds producing 67.5% germination. The increased germination for mechanically scarified seeds through nicking suggests that seed dormancy in Albizia lebbeck is mainly due to its hard seed coat. Therefore, it is recommended to farmers to adopt use of nicking and large seeds, since it is safe and effective.
Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China
Authors: Shi Zhihong , Zhang Ying , Yue Wei , Liu Mengyuan , Huo Ya Ruth , Liu Shuling , Liu Shuai , Xiang Lei , Liu Ping , Lu Hui , Wang Jinhuan , Ji Yong
Published: July 2013

Aims: The aim of this study was to estimate the prevalence of cognitive impairment (CI) in individuals aged 80 years and over in rural China and to analyze the associated risk factors. Methods: We conducted a two-phase door-to-door survey of a population in rural Ji County (China). The reference population consisted of individuals aged 80 years or older. A total of 723 individuals were interviewed in their homes, and demographic variables and comorbidities were recorded. Diagnoses were divided into the following 3 categories: normal cognitive function, cognitive impairment no dementia (CIND), and dementia. The odds ratio for each risk factor was calculated by logistic regression analysis. Results: The prevalence of CI among individuals aged 80 years and older was 73.2% (47.4% CIND and 25.7% dementia). The risk of CI decreased with a higher level of education and a higher level of social involvement. The risk of CI was higher in females than in males and among people with a history of stroke (p < 0.01). Conclusions: The observed raw prevalence of CI was 73.2%. Female gender and a history of a previous stroke increased the risk of CI, while a higher educational level and engagement in social activities reduced the risk of CI.
The NIHSS Supplementary Motor Scale: A Valid Tool for Multidisciplinary Recovery Trials
Authors: Leira Enrique C. , Coffey Christopher S. , Jorge Ricardo E. , Morton Susanne M. , Froehler Michael T. , Davis Patricia H. , Adams Jr. Harold P.
Published: July 2013

Background: There is a growing interest in therapies that may augment motor recovery that could be initiated in the acute stroke unit and maintained through the rehabilitation period. Homogenization of the currently fragmented stroke clinicometrics is necessary before such multidisciplinary trials can be conducted. The supplementary motor scale of the NIH Stroke Scale (SMS-NIHSS) is a simple and reliable scale for assessing proximal and distal motor function in the upper and lower extremities. We hypothesized that the currently underutilized SMS-NIHSS is a valid tool for assessing motor recovery with prognosticative value. Methods: We performed an analysis of SMS-NIHSS scores recorded in 1,281 patients enrolled in the Trial of ORG 10172 in Acute Stroke Treatment (TOAST). We plotted the probability of a favorable outcome (FO) and very favorable outcome (VFO) at 3 months based on the baseline SMS-NIHSS scores. In order to better study the relationship between SMS-NIHSS and 3-month functional outcome, we performed multivariate logistic regression analyses using both FO and VFO as outcome measures. Analyses were adjusted for potential confounders such as age, sex, side of the lesion, time from symptom onset to emergency room arrival, temperature, systolic blood pressure, blood glucose level and treatment group assignment (ORG 10172 vs. placebo). We also calculated the Spearman correlation coefficient between the SMS-NIHSS, Barthel Index (BI) and Glasgow Outcome Score (GOS) obtained at the 3-month visit. Results: The mean SMS-NIHSS scores were 8.18 at baseline and 4.68 at 3 months. The SMS-NIHSS scores showed a gradual improvement during the first 3 months after stroke. There was a linear relationship between the baseline SMS-NIHSS scores and the probability of an FO or VFO at 3 months. The SMS-NIHSS baseline score was an independent predictor of FO (OR = 0.86; 95% CI 0.84-0.87; p < 0.0001) and VFO (OR = 0.85; 95% CI 0.84-0.87; p < 0.0001) at 3 months after adjusting for confounders. The degree of improvement in the SMS-NIHSS scores from baseline to 3 months was also independently associated with FO and VFO (p < 0.0001). At 3 months, SMS-NIHSS scores showed a strong correlation with the BI (r = -0.70; p < 0.0001) and GOS (r = 0.73; p < 0.0001). Conclusions: The SMS-NIHSS is a valid scale for assessing motor recovery with prognosticative value, and may be sensitive to changes during recovery. Given that the SMS-NIHSS is an extension of the widely accepted NIHSS, it could be easily implemented in trials conducted in a variety of clinical research settings, including acute stroke hospitals and rehabilitation units.
Erythropoietin Combined with ACE Inhibitor Prevents Heart Remodeling in 5/6 Nephrectomized Rats Independently of Blood Pressure and Kidney Function
Authors: Gut Nadezda , Piecha Grzegorz , Aldebssi Firas , Schaefer Sebastian , Bekeredjian Raffi , Schirmacher Peter , Ritz Eberhard , Gross-Weissmann Marie-Luise
Published: July 2013

Background: Cardiovascular disease is the primary cause of mortality in patients with chronic kidney disease (CKD). Heart remodeling in CKD comprises mainly interstitial fibrosis and capillary loss. Beyond correcting renal anemia, erythropoietin (Epo) has potentially beneficial pleiotropic effects on heart remodeling. Methods: 12-week-old male Sprague-Dawley rats were randomized to 5/6 nephrectomy (NX) or sham operation (sham-op); subsequently, they received murine Epo (2.5 μg/kg/week), enalapril (12 mg/kg/day), Epo + enalapril, Epo + dihydralazine (25 mg/kg/day), or vehicle. Heart function and morphology was assessed after 16 weeks of treatment. Results: Compared with sham-op (81.2%), left ventricle fractional shortening was reduced in vehicle-treated NX (66.3%) and this was ameliorated by Epo (72.6%) and even prevented by enalapril (80.6%). Capillary length density was lower and the area of fibrosis more marked in vehicle-treated NX compared to sham-op. Capillary rarefaction and heart fibrosis were prevented in NX treated with Epo + enalapril and reduced in NX treated with enalapril and Epo + dihydralazine. Despite higher blood pressure, treatment with Epo reduced heart fibrosis but failed to prevent capillary loss. In parallel, expression of the p47phox NADPH oxidase was higher in untreated NX and was effectively reduced in NX treated with Epo + enalapril. Under basal conditions there was no difference between the groups regarding myocardial hypoxia as reflected by pimonidazole staining. Conclusion: Epo in combination with enalapril caused additive reduction of cardiac fibrosis and microvessel disease in 5/6 nephrectomized rats presumably by decreasing myocardial oxidative stress.