bluuebunny/crossref_metadata_2025 huggingface dataset:
Recruitment of low-income pregnant women into a dietary and dental care intervention: lessons from a feasibility trial
Authors: Adegboye Amanda Rodrigues Amorim , Cocate Paula G , Benaim Camila , Carvalho Maria Claudia da Veiga , Schlüssel Michael M , Castro Maria Beatriz T , Kac Gilberto , Heitmann Berit L
Published: July 2019

Background

There are difficulties in carrying out research in low-income urban communities, but the methodological challenges and suggestions on how to deal with them are often undocumented. The aim of this study is to describe the challenges of recruiting and enrolling low-income pregnant women with periodontitis to a clinical trial on vitamin D/calcium milk fortification and periodontal therapy (PT) and describe the patient-, study protocol- and setting-related factors related to women’s ineligibility and refusal to participate in the study

Methods

Qualitative and quantitative data on recruitment to a 2x2 factorial feasibility clinical trial were used. 18 women attending the health centre in a low-income area in Duque de Caxias (Rio de Janeiro, Brazil) took part in focal group discussions and data were thematically analysed. Quantitative data were analysed using appropriate descriptive statistics, including absolute and relative frequencies.

Results

Of all referrals (767), 548 (78.5%) did not meet the initial eligibility criteria. The main reason for exclusion (58%) was advanced gestational age (>20 weeks) at first prenatal appointment. The study recruited 70 women in 56 weeks and did not reach the benchmark of 120 women in 36 weeks (58.3% of the original target). Recruitment was severely hindered by health centre closures due to general strikes. Non-participation of those eligible after periodontal examination was approximately 24% (22 out 92) and predominantly associated with patient-related barriers (e.g. transportation barriers, family obligations, unresponsive to phone calls, and disconnected telephones). The recruitment yields were 9.1% (70/767) of all women contacted at first prenatal visit and 76.1% (70/92) of those screened eligible and enrolled in the trial. Women did not report concerns regarding random allocation and considered fortified milk as a healthy and safe food for pregnant women. Some women reported that financial constraints (e.g. transportation cost) could hinder participation in the study.

Conclusion

Engagement between the research team and health centre staff (e.g. nurses) facilitated referral and recruitment, yet some pregnant women failed to participate in the study largely due to significant patient-related socio-demographic barriers and setting-related factors. Our data illustrates the complexity of overcoming recruitment and enrolment challenges for clinical trials in resource-limited settings.
Accessibility of basic paediatric emergency care in Malawi: analysis of a national facility census
Authors: Johansson Emily White , Lindsjo Cecilia , Weiss Daniel , Nsona Humphreys , Selling Katarina Ekholm , Lufesi Norman , Hildenwall Helena
Published: July 2019

Background

Emergency care is among the weakest parts of health systems in low-income countries. Previous studies estimated accessibility to emergency care based on population travel times to nearest hospital with no assessment of hospital readiness to provide such care. We analysed a Malawi national facility census with comprehensive inventory audits and geocoded facility locations to identify hospitals equipped to provide basic paediatric emergency care with estimated travel times to these hospitals from non-equipped facilities and relative to Malawi’s population distribution.

Methods

We analysed a Malawi national facility census in 2013-2014 to identify hospitals equipped to manage critically ill children according to an extended version of WHO Emergency Triage, Assessment and Treatment (ETAT) guidelines. These guidelines include 25 components including staff, transport, equipment, diagnostics, medications, fluids, feeds and consumables that defined an emergency-equipped hospital in our study. We estimated travel times to emergency-equipped hospitals from non-equipped facilities and relative to population distributions using geocoded facility locations and an established accessibility mapping approach using global road network datasets from OpenStreetMap and Google.

Results

Four (3.5%, 95% CI: 1.3-8.9) of 116 Malawi hospitals were emergency-equipped. Least available items were nasogastric tubes in 34.5% of hospitals (95% CI: 26.4-43.6), blood typing services (40.4%, 95% CI: 31.9-49.6), micro nebulizers (50.9%, 95% CI: 41.9-60.0), and radiology (54.2%, 95% CI: 45.1-63.0). Nationally, the median travel time from non-equipped facilities to the nearest emergency-equipped hospital was 73 minutes (95% CI: 67-77) ranging 1-507 minutes. Approximately one-quarter (27%) of Malawians lived over 120 minutes from an emergency-equipped hospital with significantly better accessibility in Central than North and South regions (16% vs. 38% and 35%, p<0.001).

Conclusions

There are unacceptable deficiencies in accessibility of basic paediatric emergency care in Malawi. Reliable supply chains for essential drugs and commodities are needed, particularly nasogastric tubes, asthma drugs and blood, along with improved capacity for time-sensitive referral. Further child mortality reductions will require substantial investments to expand basic paediatric emergency care into all Malawi hospitals for better managing critically ill children at highest mortality risk.
Husband’s Willingness-to-Pay for HIV and Syphilis Screening at Antenatal Care Clinic under the Thai Universal Coverage Scheme
Authors: Anunsittichai Orawan , Pongpirul Krit , Puthanakit Thanyawee , Roowicha Koranit , Kaewprasert Jirarat , Songtaweesin Wipaporn Natalie , Chaithongwongwattana Surasith
Published: July 2019

Background Screening for sexually transmitted infection (STI) especially HIV as early detection and treatment have been financially supported under the Thai Universal Coverage (UC) scheme since 2009 (THB140 for HIV). However, there has been no evidence-based strategic risk-based implementation nor economic evaluation whereas husbands who accompanied the pregnant women are likely to have lower risk than those who did not come along. This study is aimed to explore husband’s willingness-to-pay (WTP) for his HIV and syphilis screenings at ANC.
Methods A survey of 200 randomly selected husbands of pregnant women was conducted at King Chulalongkorn Memorial Hospital from April to June 2018. A pilot study using an open-ended question was conducted to estimate the mean and standard deviation of WTP for HIV and syphilis screenings. Then, two contingent valuation methods (bidding and payment scale) were performed for the final WTP assessments, using the mean WTP identified from the pilot study as a starting WTP with 1⁄4 SD step up/down. Multivariate linear regression was performed to explore potential determinants of the price that the husbands are willing to pay.
Results During the study period, 597 pregnant women received their first ANC. Of 368 accompanying husbands, 200 were enrolled in the study. Their median age was 31 (IQR 27-36) years old and 67% had a first child. Eighty-eight percent of the participants were willing to test for STIs. Based on the bidding method, WTP for HIV and syphilis tests were US$14.5 (IQR 12.4-14.5) and US$9.7 (IQR 10-12), respectively. The payment scale method suggested approximately three-quarter of the price. Expecting the first child and higher education were associated with a higher price (P <0.01).
Conclusions The husbands presented at antenatal care clinic are willing to pay at least two times the cost of the STI test. The financial support to promote STI screenings should be reconsidered to cover other groups with higher sexual behavior risks and less willingness-to- pay.
Management Outcome and Associated Factors among Intestinal Obstruction Patients Treated Surgically, Eastern Ethiopia
Authors: Derseh Tesfaye , Minuye Biniam , Yusouf Mohammed , Dingeta Tariku
Published: July 2019

Background

Intestinal obstruction is a global problem consuming much in terms of surgical services. It is a common surgical emergency and a significant health problem in Ethiopia. Several factors contribute to poor management outcomes in the case of intestinal obstruction. Post-operative mortality rate ranges from 3% to 30%. Despite this high rate of mortality, there is no recently published literature that has explored Intestinal Obstruction and its associated factors at Chiro General Hospital.

Methods

Institution based cross-sectional study was conducted among 254 of patients admitted with Intestinal obstruction who treated surgically at Chiro General Hospital. Data were collected using checklists from individual patient cards by trained three BSc nurses from 13 to 18 July 2018 and completeness of data collection was checked every day by the principal Investigator. Data were entered to Epi-Data version 3.1 computer software and exported to SPSS statistical software version 22 for analysis. Bivariable binary logistic regression was used to saw the association between each independent variable and dependent variable. All variables with P-value < 0.2 during bi-variable analyses were considered for multivariable logistic regression analyses. Odds ratio along with 95%CI were estimated to measure the strength of the association. Level of statistical significance was declared at p value less or equal to 0.05.

Results

In this study the magnitude of unfavorable outcome of Intestinal Obstruction was 21.3% (95% CI: (16.5, 26.4). Age group of 55 years or above [AOR=2.9, 95%CI: (1.03, 8.4)], duration of illness of 24hrs or above [AOR=3.1, 95%CI: (1.03, 9.4)], pre-operative diagnosis of gangrenous SBO & gangrenous LBO [(AOR=3.6, 95%CI: (1.3, 9.8)), (AOR=4.2, 95%CI: (1.3, 13.7))], respectively were significantly associated with unfavorable outcome.

Conclusions

The magnitude of unfavourable management outcome of patients with Intestinal obstruction who treated surgically in this study was high. Old age, late presentation of illness and gangrenous bowel obstruction were significantly associated with unfavourable management outcome. So that early detection prompt management of patients with Intestinal obstruction reduce the occurrence of unfavourable outcome of patients.
IS RADIOGRAPHIC LUMBAR SPONDYLOLISTHESIS ASSOCIATED WITH OCCUPATIONAL EXPOSURES? FINDINGS FROM A NESTED CASE CONTROL STUDY WITHIN THE WAKAYAMA SPINE STUDY
Authors: Ishimoto Yuyu , Cooper Cyrus , Ntani Georgia , Yamada Hiroshi , Hashizume Hiroshi , Nagata Keiji , Muraki Shigeyuki , Tanaka Sakae , Yoshida Munehito , Yoshimura Noriko , Walker-Bone Karen
Published: July 2019

Objective

To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS).

Design

The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures.

Results

In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, occupational driving ≥ 2hours/day was associated with a doubling of the risk of being a case (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, working in the agricultural/ fishing industries was associated with a greater than 3-fold increased risk of spondylolisthesis (OR 3.47, 95% CI 1.29-9.29) among those aged <75 years. Climbing slopes/steps and walking were associated with reduced odds ratios.

Conclusions

A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.
Simulation Study on the Effect of Grading Diagnosis and Treatment Based on System Dynamics Model in the Context of Medical Alliance——Taking Jiangsu Province as An Example
Authors: tang shaoliang , Qiu Jiahuan , Tang Kean
Published: July 2019

Abstract: Objective

To study the core influencing factor of the implementation of Grading diagnosis and treatment system in the context of Jiangsu medical alliance. Methods By constructing the grading diagnosis and treatment system dynamics model under the background of medical alliance, the number of first-time treatments at the primary level was taken as the core evaluation index. By intervening on different targets, we would study the influence on the core evaluation index. Results The selected six intervention targets had positive effects on graded diagnosis and treatment. Among them, the intervention of medical resource subsidence, the construction of information platform between medical alliances and the technical level of primary level had the greatest impact. Conclusion In order to better promote the development of the grading diagnosis and treatment system, we can focus on the construction of medical alliances: For example, implementing the sinking of high quality medical resources in the medical alliance to strengthen the discipline construction of primary level; breaking the information island in the medical alliance, and strengthening the construction of information platform; building and expanding the green channel for two-way referral, implementing the differentiation of medical insurance policies, and improving the mechanism of benefit sharing in the medical alliances to gradually realize the orderly rationalization of medical treatment.
The emotional labour of quality improvement work in end of life care: a qualitative study of Patient and Family Centred Care in England
Authors: Boulton Richard , Boaz Annette
Published: July 2019

BACKGROUND
There is a growing emphasis on understanding patient experience in order to inform efforts to support improvement. This paper reports findings from an implementation study of an evidence based intervention called Patient and Family Centred Care (PFCC) designed to tap into patient experience as a basis for improvement. In this study the PFCC intervention was spread to a new service area (end of life care) and delivered at scale in England. The findings presented here focus specifically on one key aspect of the intervention: staff shadowing of patients, designed to help staff connect emotionally with patients’ experiences of their service in order to bring about improvements.
METHODS
The study methods were ethnographic observations of key events, semi-structured interviews with members of participating teams and the programme implementation support team and managers, and a review of the documents used in the set up and running of the programme.
RESULTS
One of the key strengths of the PFCC approach is to encourage staff through shadowing to engage with patient experience of services. Many staff described the process of shadowing as a transformative experience that alerted them to immediate areas where their services could be improved. However, engaging with patient experience of end of life care services also had unintended consequences for some staff in the form of emotional labour. Furthermore, we observed difficulties encountered by staff that are not accounted for in the existing PFCC literature relating to how care service structures may unevenly distribute the amount of ‘emotional labour’ that staff members need to invest in implementing the programme.
CONCLUSIONS
Connecting with patient experience is a crucial aspect of a number of quality improvement interventions that aim to help staff to engage with the lived experience of their services and reconnect their motivations for working in the health care system. However, there may be unintended consequences for health care staff, particularly in sensitive areas of service delivery such as end of life care. The ‘emotional labour’ for staff of engaging in quality improvement work informed by patient experience should be considered in planning and supporting patient experience led quality improvement.
The diversity between curatively resected pancreatic head and body-tail cancers based on the 8th edition of AJCC staging system: a multicenter cohort study
Authors: Sheng Weiwei , Dong Ming , Wang Guosen , Shi Xiaoyang , Gao Wei , Wang Kewei , Song He , Shi Gang , Tan Xiaodong
Published: July 2019

Background
To our knowledge, there are no studies to systematically compare the detailed clinical significance between curatively resected pancreatic head (ph) and body-tail (pbt) ductal cancers based on the new 8th edition of AJCC staging system (8th AJCC stage) that was just applied in clinical practice in 2018.

Methods

351 cases of curatively resected pancreatic adenocarcinoma (PC) patients from three center hospitals were entered into this multicenter cohort study.

Results

Increasing tumor size (P<0.001), T stage (T1+T2 vs T3+T4, P=0.003), frequent postoperative liver metastasis (PLM) (P=0.002) and 8th AJCC stage (IA to VI, P<0.001; I+II vs III+IV, P=0.002) were closely associated with the progression of pbt cancers compared with that in ph cancer patients. Moreover, tumor size≥3cm (P=0.012), 8th AJCC stage (III+IV) (P=0.025) and PLM (P=0.010) were identified as independent risk factors in pbt cancers in logistic analysis. Patients with pbt cancers had a significantly worse overall survival compared with ph cancer patients (P=0.007). Moreover, pbt was an independent unfavorable factor in multivariate analysis (P=0.009). In addition to 8th AJCC stage, vascular invasion and PLM, increasing tumor size tumor size and advanced T stage were also closely associated with the poor prognosis in 131 cases of pbt cancer patients compared with Ph cancers.

Conclusion

Pbt, as an independent unfavorable factor for the prognosis of PC patients, are much more aggressive than that in ph cancers according to 8th AJCC staging system. 8th AJCC staging system are more comprehensive and sensitive to reflect the malignant biology of pbt cancers.
Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases?
Authors: Cortez-Maya Sandra , Moreno-Herrera Antonio , Palos Isidro , Rivera Gildardo
Published: July 2019

Parasitic diseases, caused by helminths (ascariasis, hookworm, trichinosis, and schistosomiasis)
and protozoa (chagas, leishmaniasis, and amebiasis), are considered a serious public
health problem in developing countries. Additionally, there is a limited arsenal of anti-parasitic
drugs in the current pipeline and growing drug resistance. Therefore, there is a clear need for the
discovery and development of new compounds that can compete and replace these drugs that have
been controlling parasitic infections over the last decades. However, this approach is highly resource-
intensive, expensive and time-consuming. Accordingly, a drug repositioning strategy of the
existing drugs or drug-like molecules with known pharmacokinetics and safety profiles is alternatively
being used as a fast approach towards the identification of new treatments. The artemisinins,
mefloquine, tribendimidine, oxantel pamoate and doxycycline for the treatment of helminths, and
posaconazole and hydroxymethylnitrofurazone for the treatment of protozoa are promising candidates.
Therefore, traditional antiprotozoal drugs, which were developed in some cases decades ago,
are a valid solution. Herein, we review the current status of traditional anti-helminthic and antiprotozoal
drugs in terms of drug targets, mode of action, doses, adverse effects, and parasite resistance
to define their suitability for repurposing strategies. Current antiparasitic drugs are not only
still viable for the treatment of helminth and protozoan infections but are also important candidates
for new pharmacological treatments.
Plant Extracts Loaded in Nanostructured Drug Delivery Systems for Treating Parasitic and Antimicrobial Diseases
Authors: Gondim Brenna L.C. , Oshiro-Júnior João A. , Fernanandes Felipe H.A. , Nóbrega Fernanda P. , Castellano Lúcio R.C. , Medeiros Ana C.D.
Published: July 2019

Background: Plant extracts loaded in nanostructured drug delivery systems (NDDSs) have been reported
as an alternative to current therapies for treating parasitic and antimicrobial diseases. Among their advantages,
plant extracts in NDSSs increase the stability of the drugs against environmental factors by promoting
protection against oxygen, humidity, and light, among other factors; improve the solubility of hydrophobic compounds;
enhance the low absorption of the active components of the extracts (i.e., biopharmaceutical classification
II), which results in greater bioavailability; and control the release rate of the substances, which is fundamental
to improving the therapeutic effectiveness. In this review, we present the most recent data on NDDSs using
plant extracts and report results obtained from studies related to in vitro and in vivo biological activities.
The Relationship between Ferroptosis and Tumors: A Novel Landscape for Therapeutic Approach
Authors: Xia Xiaojun , Fan Xiaoping , Zhao Mingyi , Zhu Ping
Published: July 2019

Background:

Ferroptosis is a newly discovered form of iron-dependent oxidative cell death characterized by lethal accumulation of lipid-based reactive oxygen species (ROS). It is distinct from other forms of cell death including apoptosis, necrosis, and autophagy in terms of morphology, biochemistry and genetics.

Discussion:

Ferroptosis can be induced by system xc- inhibitors or glutathione peroxidase 4 (GPx4) inhibitors, as well as drugs such as sorafenib, sulfasalazine (SAS), and artesunate (ART). Ferroptosis has been recently shown to be critical in regulating growth of tumors, such as hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC), ovarian cancer, pancreatic carcinoma, and diffuse large B cell lymphoma (DLBCL). Ferroptosis is also associated with resistance to chemotherapeutic drugs and the anti-tumor efficacy of immunotherapy.

Conclusion:

This review summarizes the mechanism of ferroptosis and its relationship with different types of tumors, to advance our understanding of cell death and to find a novel approach for clinical cancer management.
Recent Advances of Small Molecular Regulators Targeting G Protein- Coupled Receptors Family for Oncology Immunotherapy
Authors: He Peng , Zhou Wenbo , Liu Mingyao , Chen Yihua
Published: July 2019

The great clinical success of chimeric antigen receptor T cell (CAR-T) and PD-1/PDL-1 inhibitor therapies suggests the drawing of a cancer immunotherapy age. However, a considerable proportion of cancer patients currently receive little benefit from these treatment modalities, indicating that multiple immunosuppressive mechanisms exist in the tumor microenvironment. In this review, we mainly discuss recent advances in small molecular regulators targeting G Protein-Coupled Receptors (GPCRs) that are associated with oncology immunomodulation, including chemokine receptors, purinergic receptors, prostaglandin E receptor EP4 and opioid receptors. Moreover, we outline how they affect tumor immunity and neoplasia by regulating immune cell recruitment and modulating tumor stromal cell biology. We also summarize the data from recent clinical advances in small molecular regulators targeting these GPCRs, in combination with immune checkpoints blockers, such as PD-1/PDL-1 and CTLA4 inhibitors, for cancer treatments.
Cell Penetrating Peptide: Sequence-Based Computational Prediction for Intercellular Delivery of Arginine Deiminase
Authors: Zarei Mahboubeh , Rahbar Mohammad Reza , Negahdaripour Manica , Morowvat Mohammad Hossein , Nezafat Navid , Ghasemi Younes
Published: July 2019

Background:

Cell-Penetrating Peptides (CPPs), a family of short peptides, are broadly used as the carrier in the delivery of drugs and different therapeutic agents. Thanks to the existence of valuable databases, computational screening of the experimentally validated CPPs can help the researchers to select more effective CPPs for the intercellular delivery of therapeutic proteins. Arginine deiminase of Mycoplasma hominis, an arginine-degrading enzyme, is currently in the clinical trial for treating several arginine auxotrophic cancers. However, some tumor cells have developed resistance to ADI treatment. The ADI resistance arises from the over-expression of argininosuccinate synthetase 1 enzyme, which is involved in arginine synthesis. Intracellular delivery of ADI into tumor cells is suggested as an efficient approach to overcome the aforesaid drawback.

Objective:

In this study, in-silico tools were used for evaluating the experimentally validated CPPs to select the best CPP candidates for the intracellular delivery of ADI.

Results:

In this regard, 150 CPPs of protein cargo available at CPPsite were retrieved and evaluated by the CellPPD server. The best CPP candidates for the intracellular delivery of ADI were selected based on stability and antigenicity of the ADI-CPP fusion form. The conjugated forms of ADI with each of the three CPPs including EGFP-hcT (9-32), EGFP-ppTG20, and F(SG)4TP10 were stable and nonantigenic; thus, these sequences were introduced as the best CPP candidates for the intracellular delivery of ADI. In addition, the proposed CPPs had appropriate positive charge and lengths for an efficient cellular uptake.

Conclusion:

These three introduced CPPs not only are appropriate for the intracellular delivery of ADI, but also can overcome the limitation of its therapeutic application, including short half-life and antigenicity.
Azacyanines as Novel Topoisomerase II Alpha Inhibitors
Authors: Guloglu Sercan , Kirmaci Fahriye Nur , Çetinkol Özgül Persil , Forough Mehrdad , Gulkaya Aybuke
Published: July 2019

Introduction:

Topoisomerase II alpha (Topo IIα) has become one of the extensively exploited targets in chemotherapy due to its role in regulating the topological constraints of DNA during replication and transcription. Small molecules targeting Topo IIα’s activity such as etoposide (VP-16) and doxorubicin are extensively used in the treatment of many different types of cancer.

Objective:

Here, the effects of three small molecules, named as azacyanines, on Topo IIα have been assessed.

Methods:

In-vitro Topoisomerase IIα drug screening kit and agarose gel imaging were used for the assessment of Topo IIα’s activity.

Results:

Our results revealed that all the azacyanines investigated decreased the catalytic activity of Topo IIα dramatically. More importantly, the decrease in the catalytic activity of Topo IIα in the presence of azacyanines was higher than the presence of VP-16, which is a commercially available chemotherapy drug. Upon further investigation, it has been observed that Azamethyl’s catalytic inhibition of Topo IIα was concentration dependent and the catalytic activity of Topo IIα was almost completely abolished in the presence of 100.0 μM of Azamethyl.

Conclusion:

These findings reveal the potential of azacyanines as effective Topo IIα inhibitors and chemotherapeutic agents.
Positive Association Between Plasma Levels of Advanced Glycation and Precursor of Lipoxidation end Products with Gastrointestinal Problems in Children with Autism
Authors: Ghodsi Ramin , Kheirouri Sorayya
Published: July 2019

Background:

Increased oxidative stress has been reported in autistic patients besides,
evidence linking oxidative stress to enhancement of advanced glycation and lipoxidation end products
(AGEs and ALEs) and their precursors.

Objective:

This study aimed to compare the plasma levels of the AGEs and precursors of ALEs in
autistic and healthy children and to evaluate their relationship with autism comorbidities.

Methods:

In this descriptive study, 54 children, 36 autistic and 18 healthy participated. Plasma levels
of AGEs and precursors of ALEs were measured by ELISA method. Severity of autism and
Gastrointestinal (GI) disorders were measured by GARSII questionnaire and QPGS-ROME III
questionnaire, respectively.

Results:

Plasma levels of AGEs and precursors of ALEs in autistic children were comparable with
healthy children. Plasma levels of AGEs and precursor of ALEs were correlated with physical activity
and GI disorders in autistic children. A strong association was also found between AGEs and
precursors of ALEs.

Conclusions:

The results indicate that AGEs and ALEs have a strong correlation together but the
AGEs and precursor of ALEs in autistic children are not different from healthy children.
Cognitive Behavioral Therapy Online for Adult Depression: A 10 Year Systematic Literature Review
Authors: Stavropoulos Vasileios , Cokorilo Sandra , Kambouropoulos Alexa , Collard James , Gomez Rapson
Published: July 2019

Background:

Acceptance, adherence and efficacy aspects of Cognitive Behavioural Therapy (CBT) online have invited significant interest, especially in the context of “stepped care” models, which advocate progressive stages of intervention in addressing depression. Objectives: The current work aspires to comprehensively identify critical factors linked to the applicability of online CBT, in order to inform clinical practices and future research targeting depressive behaviors in early and middle adulthood.

Methods:

To serve these goals: a) the PRISMA systematic literature perspective is followed; b) a systematic search of online databases between 2008-2018 was undertaken and; c) a compositehybrid model, resulting from the integration of broadly adopted conceptualizations from the areas of psychological treatment and internet use behaviors, was combined with an interpretative phenomenological analysis perspective to organize the findings.

Results:

In total, 28 studies were included in the present review. Factors defining the efficacy, adherence and acceptability of online CBT targeting depression (during early and middle adulthood) were classified into parameters related to the individual receiver, the context and the CBT activities involved.

Conclusion:

Despite the cautiousness warranted by the limitations, as well as the diverge methodology of the reviewed studies, findings appear to favour the provision of brief, therapist supported, online CBT interventions, especially in addressing moderate depression during early and middle adulthood.
The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy
Authors: Chen Wan , Liang Xingmei , Nong Zhihuan , Li Yaoxuan , Pan Xiaorong , Chen Chunxia , Huang Luying
Published: July 2019

Hyperbaric Oxygenation Therapy (HBOT) is used as an adjunctive method for multiple diseases. The method meets the routine treating and is non-invasive, as well as provides 100% pure oxygen (O2), which is at above-normal atmospheric pressure in a specialized chamber. It is well known that in the condition of O2 deficiency, it will induce a series of adverse events. In order to prevent the injury induced by anoxia, the capability of offering pressurized O2 by HBOT seems involuntary and significant. In recent years, HBOT displays particular therapeutic efficacy in some degree, and it is thought to be beneficial to the conditions of angiogenesis, tissue ischemia and hypoxia, nerve system disease, diabetic complications, malignancies, Carbon monoxide (CO) poisoning and chronic radiation-induced injury. Single and combination HBOT are both applied in previous studies, and the manuscript is to review the current applications and possible mechanisms of HBOT. The applicability and validity of HBOT for clinical treatment remain controversial, even though it is regarded as an adjunct to conventional medical treatment with many other clinical benefits. There also exists a negative side effect of accepting pressurized O2, such as oxidative stress injury, DNA damage, cellular metabolic, activating of coagulation, endothelial dysfunction, acute neurotoxicity and pulmonary toxicity. Then it is imperative to comprehensively consider the advantages and disadvantages of HBOT in order to obtain a satisfying therapeutic outcome.
Preparation of Quercetin Loaded Microparticles and their Antitumor Activity against Human Lung Cancer Cells (A549) in vitro
Authors: Li Chen , Gao Liufang , Zhang Yi , Simpson Benjamin K.
Published: July 2019

Background:

Novel quercetin-loaded microparticles (QM) were fabricated using coaxial
electrospraying, characterized for surface morphology and release profile, and evaluated for antitumor
activity in vitro.

Methods:

QM exhibited an average diameter of 1.69 ±1.13 mm, which was an appropriate size suitable
for respiratory delivery. X-ray diffraction patterns showed that the components in QM existed in an
amorphous physical form, leading to favorable interactions between the drug (quercetin), the polymer
matrix (polyvinylpyrrolidone, PVP) and other excipients (sodium dodecyl sulfate and sucralose).

Results:

QM performed much faster release rate compared with free quercetin powder (Q) in vitro.
Furthermore, QM also showed more potent inhibitory effects on A549 cell growth with reduced cell
viability, decreased cell migration and induced more G0/G1 phase cell cycle arrest than Q.

Conclusion:

Thus, the quercetin loaded microparticles exhibited more potent inhibitory effects than
free quercetin on A549 cell. The increased antitumor activity could be attributed to the enhanced
accumulation of quercetin in the A549 cells with the QM. However, further studies are necessary to
elucidate the exact mechanisms.
Corrigendum to: The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome
Authors: Dikci Seyhan , Öztürk Emrah , Fırat Penpe Gül , Yılmaz Turgut , Taşkapan Mehmet Çağatay , Yoloğlu Saim
Published: July 2019

In the Original Article by Dikci et al. “The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/
Syndrome” (Endocr Metab Immune Disord Drug Targets. 2019; 19(2):166-170) after publication of the article it has
come to the corresponding author's attention that there were some errors in the article. In the introduction section, reference 3
should be changed as reference 2 (paragraph 1, line 4) and references 4-6 should be changed as references 3-6 (paragraph 1,
lines 6,7). Reference numbers in the references section should be as follows. References 25-28 should be changed as references
7-10 respectively. References 7-24 should be changed as references 11-28 respectively.
Evaluation of TG-HDL Ratio Instead of HOMA Ratio as Insulin Resistance Marker in Overweight and Children with Obesity
Authors: Behiry Eman G. , El Nady Nazih Mohamed , AbdEl Haie Omima M. , Mattar May Kamel , Magdy Amira
Published: July 2019

Background:

Homeostasis model assessment for insulin resistance (HOMA-IR) is widely
used as a marker of insulin resistance in adults and has also been validated in children and adolescents.
Triglyceride (TG) and HDL-C on the other hand is a routine test and inexpensive compared to insulin.
Previous studies reported conflicting findings on the usefulness of the triglyceride to HDL-C ratio
(TG:HDL-C ratio) as predictor or marker of IR. The aim of this work was to investigate the usefulness
of Triglyceride to HDL-C ratio (TG/HDL-C) as an Insulin Resistance (IR) marker in overweight and
children with obesity.

Methods:

This study was a comparative cross sectional study which was conducted on ninety overweight
and children with obesity attending National Nutrition Institute “Pediatric obesity clinic. They
were classified into 2 groups as follows: group (1) included overweight and children with obesity with
insulin resistance, group (2) included overweight and children with obesity with non-insulin resistance.
All the subjects were subjected to history, clinical examination and laboratory investigations including
total lipid profile, fasting glucose, insulin and TG:HDL-C ratio instead of HOMA ratio.

Results:

Prevalence of IR among the studied sample was 42 (46.7%). Mean value of TG/ HDL-C ratio
was greater among the insulin resistance group than non insulin resistance group (p value= <
0.001)value). TG/HDL ratio ≥1.36 had 85.7% sensitivity, 66.7% specificity. There was statistically
significant positive correlation between TG/HDL ratio and HOMA-IR.

Conclusion:

TG:HDL ratio ≥1.36 is a significant early and sensitive predictor of insulin resistance in
children instead of HOMA-IR.
Pengembangan model aquarobic exercise untuk pembakaran lemak pada overweight
Authors: Sanusi Rahmat , Widiyanto Widiyanto
Published: July 2019

Penelitian ini bertujuan menghasilkan model latihan alternatif yang layak untuk pembakaran lemak dan sebagai latihan non-traumatic untuk orang dengan overweight. Penelitian ini merupakan penelitian pengembangan (research and development) yang mengacu pada langkah yang dikembangkan Borg & Gall melalui tahapan: pengembangan draf awal, model awal, model, uji coba produk, evaluasi dan revisi. Subjek uji coba terbatas sebanyak 3 orang dan subjek uji coba lapangan sebanyak 6 orang dengan kriteria mengalami masalah kelebihan berat badan (overweight). Pengumpulan data melalui uji pelaksanaan, penilaian ahli dengan lembar kuisioner, tes pengukuran denyut nadi dan pengukuran penurunan persentase lemak. Teknik analisis data menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa model aquarobic exercise untuk pembakaran lemak ditinjau dari bentuk, isi dan tujuan latihan oleh ahli kebugaran jasmani, ahli fisiologi dan ahli renang dikategorikan “Baik”. Hasil data pre dan post test menujukkan peningkatan nilai rata-rata denyut nadi dan penurunan persentase lemak. Disimpulkan bahwa model aquarobic exercise layak dan efektif untuk pembakaran lemak pada overweight. Developing aquarobic exercise model for fat burn in overweight AbstractThis research aim to development a alternative model for fat burn This model can and as non-traumatic exercise to people with overweight. This research is the development (research and development) which refer from  Borg & Gall prosedur was done through stage developing preliminary model, developing model, trials of product, evaluation and revision. Limited scale trials was conducted on 3 women and large scale trials was conducted on 6 womens. The instrumen used to collect data were implementation test, assessment from expert with quisioner sheet, heart rate and estimate fat percentage. Analysis techniques in this research used descriptive statistic. The results of the research show that aquarobic exercise model review from the form, content and purpose the exercise from expert assessment by physical fitnees expert, fisiologi expert and swiming expert are “good”. The result of pre and post test show there is an increase mean score heart rate and decrease fat percentage. So, it can be conclude that the aquarobic exercise modelis suitable and effetive for fat burner in overweight.
Pengembangan aplikasi tes keterampilan sepakbola berbasis web
Authors: Supriyono Eko
Published: July 2019

Penelitian bertujuan untuk menghasilkan produk Aplikasi Tes Keterampilan Sepakbola (Soccer Skill Test) Berbasis Web dan buku panduan. Penelitian ini merupakan penelitian pengembangan, melalui 5 tahapan, yaitu: (1) studi pendahuluan dan pengumpulan informasi, (2) desain produk awal, (3) validasi ahli/revisi, (4) ujicoba lapangan skala kecil/revisi, (5) uji coba skala besar dan produk akhir. Subjek penelitian adalah ahli materi, ahli media, dan pelatih Sekolah Sepakbola di Daerah Istimewa Yogyakarta. Instrumen berupa angket dan observasi. Hasil penelitian yaitu Aplikasi Tes Keterampilan Sepakbola (Soccer Skill Test) Berbasis Web yang berisi  menu pokok yaitu: (1) Menu Home, (2) Menu Panduan Tes dan Konversi Hasil Tes Keterampilan Sepakbola yang bisa di input secara individu maupun data Excel, (3) Aplikasi tes terdiri dari 7 item tes keterampilan sepakbola yaitu: tes dribbling, passing-control, shooting, passing lambung, juggilng, heading, (4) Menu contak admin. Developing web-based soccer skills test application AbstractThis research aimed to produce web-based soccer skills test application. This research belonged to research and development with model of procedural descriptive that outlined the steps which should be followed to create a product. The development of web-based soccer skills test application were done in 5 steps, namely: (1) undertaking pre-study and information collection, (2) developing design of initial product, (3) expert validation and revision, (4) small-scale field test and product revision, (5) large-scale field test and final product. The subjects of this research and development were material expert, media expert and coaches of soccer school of Yogyakarta Province (DIY). The instrument of this research were questionnaire and observation. The result of this research was a web-based soccer skills test application was produced that contained main menu, namely: (1) Home, (2) menu of test guide and the conversion of result of soccer skill test which could be inputted individually or by Excel data, (3) the test application consisted of 7 items of soccer skills, that were: test of dribbling, passing-control, shooting, long-passing, juggling, heading, (4) menu of administrator’s contact.
Karakteristik psikologis atlet Sea Games Indonesia ditinjau dari jenis cabang olahraga dan jenis kelamin
Authors: Nopiyanto Yahya Eko , Dimyati Dimyati
Published: July 2019

Penelitian ini bertujuan untuk mengungkapkan: (1) karakteristik psikologis atlet SEA Games Indonesia ditinjau dari cabang olahraga individu, (2) ditinjau dari cabang olahraga tim, (3) perbedaan karakteristik psikologis atlet SEA Games Indonesia ditinjau dari cabang olahraga individu berdasarkan jenis kelamin, dan (4) olahraga tim berdasarkan jenis kelamin. Pendekatan penelitian ini adalah ex-post facto. Penelitian ini merupakan penelitian populasi. Semua subjek dalam populasi diikutsertakan dalam penelitian dengan jumlah 273 atlet. Pengumpulan data menggunakan kuesioner The Psychological Skills Inventory for Sports. Teknik analisis data menggunakan independent sample t-test. Hasil penelitian ini menunjukkan bahwa: (1) karakteristik psikologis atlet SEA Games Indonesia ditinjau dari cabang olahraga individu dalam kategori tinggi (2) ditinjau dari cabang olahraga tim dalam kategori tinggi (3) tidak ada perbedaan yang signifikan karakteristik psikologis atlet SEA Games Indonesia ditinjau dari cabang olahraga individu berdasarkan jenis kelamin dengan nilai sig. = 0,092  > 0,05; dan (4) ada perbedaan yang signifikan karakteristik psikologis atlet SEA Games Indonesia ditinjau dari cabang olahraga tim berdasarkan jenis kelamin dengan nilai nilai sig. = 0,000 < 0,05. The psychological characteristics of Indonesian Sea Games athletes in terms of sports and sex AbstractThis research was aimed to investigate : (1) the psychological characteristics of  Indonesian SEA Games athletes in terms of individual sports, (2) in terms of team sports, (3) the psychological characteristic differences of Indonesian SEA Games athletes in terms of individual sports based on sex, and (4) the psychological characteristic differences of  Indonesian SEA Games athletes in terms of team sports based on sex. This research employed the quantitative approach using the survey method with a restrospective causal-comparative design. This research was population research. All subjects in the population were included in this research with a total of 273 athletes. The data were collected using the Psychological Skills Inventory for Sports questionnaire and analyzed using the independent sample t test at. The research findings revealed that: (1) the psychological characteristics of  Indonesian SEA Games athletes in terms of individual sports were in a high category, (2) the psychological characteristics of  Indonesian SEA Games athletes in terms of team sports are in high category, (3) there were no significant differences in the psychological characteristics of  Indonesian SEA Games athletes in terms of individual sports based on sex sig. values = 0.092  > 0.05, and (4) there were significant differences in the psychological characteristics of Indonesian SEA Games athletes in terms of team sports based on sex with sig. values = 0.000 < 0.05.
Persepsi mahasiswa Fakultas Ilmu Keolahragaan Universitas Negeri Yogyakarta terhadap atribut produk minuman kesehatan
Authors: Vidya Chairina , Nisa Fatma Zuhrotun , Palupi Ika Ratna
Published: July 2019

Pemberian cairan sangat penting bagi atlet untuk menghindari dehidrasi yang dapat menyebabkan gangguan fisiologis tubuh. Produk minuman kesehatan diyakini mampu meningkatkan energi dan menjaga produktivitas pada saat dan setelah melakukan aktivitas fisik seperti bekerja dan olahraga, terutama bagi para olahragawan. Perilaku membeli produk minuman kesehatan dilakukan berdasarkan preferensi dan kebutuhan konsumen, salah satunya mempertimbangkan atribut produk. Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa Fakultas Ilmu Keolahragaan Universitas Negeri Yogyakarta (FIK UNY) terhadap atribut produk minuman kesehatan (harga, kemasan, merek, label, dan rasa). Penelitian menggunakan desain observasional cross sectional dengan subjek penelitian 100 orang mahasiswa FIK UNY yang diambil secara purposif. Analisis data menggunakan statistik deskriptif. Hasil penelitian menunjukkan bahwa sebagian besar subjek memiliki persepsi positif terhadap atribut produk minuman kesehatan. Kemasan yang mudah dibawa dan dipegang serta informasi nilai gizi merupakan indikator yang dianggap paling penting oleh subjek. Perception on healthy drink product attributes among sports sciences college students in Universitas Negeri Yogyakarta AbstractIntake of fluids is very important for athletes to avoid dehydration which can cause physiological disorders of the body. Health drink products are supposed to increase energy and maintain productivity during and after physical activities such as work and exercise, especially for athletes. The behavior of buying health drink products is based on consumer preferences and needs, one of them considering product attributes. This study aimed to determine perception of students of the Faculty of Sport Sciences Yogyakarta State University (FIK UNY) on the attributes of health drink products (price, packaging, brand, label, and taste). The research used observational cross-sectional design. Subjects were 100 students of FIK UNY selected through purposive sampling. Data analysis employed descriptive statistics. The results showed that most respondents had positive perceptions on health drink product attributes. Packaging that was easy to carry and hold as well as information of nutritional value was an indicator that was considered most important by the subjects.
The effectiveness of video and deck card use in crafting the skills of writing experience within the elementary school students
Authors: Ambarwati Wulan , Budiningsih C Asri
Published: July 2019

The aims of this research are to find out (1) the differences of the use of video and random cards with pictures and worksheets on the skill of writing experience-story of fifth grade students of SD Negeri Panggang; (2) the effectiveness of the use of video and random cards compared to the pictures and worksheets on the skill of writing experience-story of fifth grade students of SD Negeri Panggang.The research approach is quantitative and the method is quasi-experimental with pretest and posttest. Based on the results of the calculation of the t-test, the score of posttest on the experimental group and the control group is 2.193 with df=38 obtained p=0.035 which are less than 5% (p <0.05). The t-test results showed that there was the difference between the skills of writing experience-story from the experimental group that uses video and random cards with pictures and worksheets. Gain score showed the differences in the level of per cent (t = 2.895; P <0.05) (t = 2.895; 0.006 <0.05). The results showed that video has more effective effects than random cards with pictures and worksheets on improving the skills of writing experience story of fifth-grade students of SD Negeri Panggang.