bluuebunny/crossref_metadata_2025 huggingface dataset:
Icariin Metabolism by Human Intestinal Microflora
Authors: Wu Hailong , Kim Mihyang , Han Jaehong
Published: August 2016

Icariin is a major bioactive compound of Epimedii Herba, a traditional oriental medicine exhibiting anti-cancer, anti-inflammatory and anti-osteoporosis activities. Recently, the estrogenic activities of icariin drew significant attention, but the published scientific data seemed not to be so consistent. To provide fundamental information for the study of the icaritin metabolism, the biotransformation of icariin by the human intestinal bacteria is reported for the first time. Together with human intestinal microflora, the three bacteria Streptococcus sp. MRG-ICA-B, Enterococcus sp. MRG-ICA-E, and Blautia sp. MRG-PMF-1 isolated from human intestine were reacted with icariin under anaerobic conditions. The metabolites including icariside II, icaritin, and desmethylicaritin, but not icariside I, were produced. The MRG-ICA-B and E strains hydrolyzed only the glucose moiety of icariin, and icariside II was the only metabolite. However, the MRG-PMF-1 strain metabolized icariin further to desmethylicaritin via icariside II and icaritin. From the results, along with the icariin metabolism by human microflora, it was evident that most icariin is quickly transformed to icariside II before absorption in the human intestine. We propose the pharmacokinetics of icariin should focus on metabolites such as icariside II, icaritin and desmethylicaritin to explain the discrepancy between the in vitro bioassay and pharmacological effects.
Milk Protein Polymer and Its Application in Environmentally Safe Adhesives
Authors: Guo Mingruo , Wang Guorong
Published: August 2016

Milk proteins (caseins and whey proteins) are important protein sources for human nutrition; in addition, they possess important natural polymers. These protein molecules can be modified by physical, chemical, and/or enzymatic means. Casein is one of the oldest natural polymers, used for adhesives, dating back to thousands years ago. Research on milk-protein-based adhesives is still ongoing. This article deals with the chemistry and structure of milk protein polymers, and examples of uses in environmentally-safe adhesives. These are promising routes in the exploration of the broad application of milk proteins.
Correlation or Causality between Land Cover Patterns and the Urban Heat Island Effect? Evidence from Brisbane, Australia
Authors: Deilami Kaveh , Kamruzzaman Md. , Hayes John
Published: August 2016

Numerous studies have identified associations between the surface urban heat island (SUHI) effect (i.e., SUHI, hereinafter is referred to as UHI) and urban growth, particularly changes in land cover patterns. This research questions their causal links to answer a key policy question: If cities restrict urban expansion and encourage people to live within existing urban areas, will that help in controlling UHI? The question has been answered by estimating four models using data from Brisbane, Australia: Model 1—cross-sectional ordinary least square (OLS) regression—to examine the association between the UHI effect and land cover patterns in 2013; Model 2—cross-sectional geographically weighted regression (GWR)—to examine whether the outputs generated from Model 1 possess significant spatial variations; Model 3—longitudinal OLS—to examine whether changes in land cover patterns led to changes in UHI effects between 2004 and 2013; and Model 4—longitudinal GWR—to examine whether the outputs generated from Model 3 vary significantly over space. All estimations were controlled for potential confounding effects (e.g., population, employment and dwelling densities). Results from the cross-sectional OLS and GWR models were consistent with previous findings and showed that porosity is negatively associated with the UHI effect in 2013. In contrast, population density has a positive association. Results from the longitudinal OLS and GWR models confirm their causal linkages and showed that an increase in porosity level reduced the UHI effect, whereas an increase in population density increased the UHI effect. The findings suggest that even a containment of population growth within existing urban areas will lead to the UHI effect. However, this can be significantly minimized through proper land use planning, by creating a balance between urban and non-urban uses of existing urban areas.
Mapping Forest Health Using Spectral and Textural Information Extracted from SPOT-5 Satellite Images
Authors: Meng Jinghui , Li Shiming , Wang Wei , Liu Qingwang , Xie Shiqin , Ma Wu
Published: August 2016

Forest health is an important variable that we need to monitor for forest management decision making. However, forest health is difficult to assess and monitor based merely on forest field surveys. In the present study, we first derived a comprehensive forest health indicator using 15 forest stand attributes extracted from forest inventory plots. Second, Pearson’s correlation analysis was performed to investigate the relationship between the forest health indicator and the spectral and textural measures extracted from SPOT-5 images. Third, all-subsets regression was performed to build the predictive model by including the statistically significant image-derived measures as independent variables. Finally, the developed model was evaluated using the coefficient of determination (R2) and the root mean square error (RMSE). Additionally, the produced model was further validated for its performance using the leave-one-out cross-validation approach. The results indicated that our produced model could provide reliable, fast and economic means to assess and monitor forest health. A thematic map of forest health was finally produced to support forest health management.
Adaptive Sampling-Based Information Collection for Wireless Body Area Networks
Authors: Xu Xiaobin , Zhao Fang , Wang Wendong , Tian Hui
Published: August 2016

To collect important health information, WBAN applications typically sense data at a high frequency. However, limited by the quality of wireless link, the uploading of sensed data has an upper frequency. To reduce upload frequency, most of the existing WBAN data collection approaches collect data with a tolerable error. These approaches can guarantee precision of the collected data, but they are not able to ensure that the upload frequency is within the upper frequency. Some traditional sampling based approaches can control upload frequency directly, however, they usually have a high loss of information. Since the core task of WBAN applications is to collect health information, this paper aims to collect optimized information under the limitation of upload frequency. The importance of sensed data is defined according to information theory for the first time. Information-aware adaptive sampling is proposed to collect uniformly distributed data. Then we propose Adaptive Sampling-based Information Collection (ASIC) which consists of two algorithms. An adaptive sampling probability algorithm is proposed to compute sampling probabilities of different sensed values. A multiple uniform sampling algorithm provides uniform samplings for values in different intervals. Experiments based on a real dataset show that the proposed approach has higher performance in terms of data coverage and information quantity. The parameter analysis shows the optimized parameter settings and the discussion shows the underlying reason of high performance in the proposed approach.
Trajectory Correction and Locomotion Analysis of a Hexapod Walking Robot with Semi-Round Rigid Feet
Authors: Zhu Yaguang , Jin Bo , Wu Yongsheng , Guo Tong , Zhao Xiangmo
Published: August 2016

Aimed at solving the misplaced body trajectory problem caused by the rolling of semi-round rigid feet when a robot is walking, a legged kinematic trajectory correction methodology based on the Least Squares Support Vector Machine (LS-SVM) is proposed. The concept of ideal foothold is put forward for the three-dimensional kinematic model modification of a robot leg, and the deviation value between the ideal foothold and real foothold is analyzed. The forward/inverse kinematic solutions between the ideal foothold and joint angular vectors are formulated and the problem of direct/inverse kinematic nonlinear mapping is solved by using the LS-SVM. Compared with the previous approximation method, this correction methodology has better accuracy and faster calculation speed with regards to inverse kinematics solutions. Experiments on a leg platform and a hexapod walking robot are conducted with multi-sensors for the analysis of foot tip trajectory, base joint vibration, contact force impact, direction deviation, and power consumption, respectively. The comparative analysis shows that the trajectory correction methodology can effectively correct the joint trajectory, thus eliminating the contact force influence of semi-round rigid feet, significantly improving the locomotion of the walking robot and reducing the total power consumption of the system.
A Simple BODIPY-Based Viscosity Probe for Imaging of Cellular Viscosity in Live Cells
Authors: Su Dongdong , Teoh Chai , Gao Nengyue , Xu Qing-Hua , Chang Young-Tae
Published: August 2016

Intracellular viscosity is a fundamental physical parameter that indicates the functioning of cells. In this work, we developed a simple boron-dipyrromethene (BODIPY)-based probe, BTV, for cellular mitochondria viscosity imaging by coupling a simple BODIPY rotor with a mitochondria-targeting unit. The BTV exhibited a significant fluorescence intensity enhancement of more than 100-fold as the solvent viscosity increased. Also, the probe showed a direct linear relationship between the fluorescence lifetime and the media viscosity, which makes it possible to trace the change of the medium viscosity. Furthermore, it was demonstrated that BTV could achieve practical applicability in the monitoring of mitochondrial viscosity changes in live cells through fluorescence lifetime imaging microscopy (FLIM).
An H2S Sensor Based on Electrochemistry for Chicken Coops
Authors: Zeng Lihua , He Mei , Yu Huihui , Li Daoliang
Published: August 2016

The recent modernization of the livestock industry lags behind the scale of the livestock industry, particularly in indoor environmental monitoring. In particular, the H2S gas concentration in chicken coops affects the growth and reproductive capacity of the chickens and threatens their health. Therefore, the research and development of a low-cost, environmentally friendly sensor that can achieve on-line monitoring of H2S gas has a notably important practical significance. This paper reports the design of an H2S gas sensor, with selection of an electrochemical probe with high accuracy and wide measurement range using the relatively mature technology of electrochemical sensors. Although the probe of the sensor is the main factor that affects the sensor accuracy, the probe must be combined with a specifically designed signal condition circuit that can overcome the lack of an electrode to satisfy the requirements for the interconnection and matching between the output signal and the test instrument. Because the output current of the electrochemical electrode is small and likely to be disturbed by noise, we designed signal-conditioning modules. Through the signal-conditioning circuit, the output signal of the current electrode can be converted into a voltage and amplified. In addition, we designed a power control module because a bias voltage is necessary for the electrode. Finally, after the calibration experiment, the accurate concentration of H2S gas can be measured. Based on the experimental analysis, the sensor shows good linearity and selectivity, comparatively high sensitivity, perfect stability and an extremely long operating life of up to two years.
Cardinality Balanced Multi-Target Multi-Bernoulli Filter with Error Compensation
Authors: He Xiangyu , Liu Guixi
Published: August 2016

The cardinality balanced multi-target multi-Bernoulli (CBMeMBer) filter developed recently has been proved an effective multi-target tracking (MTT) algorithm based on the random finite set (RFS) theory, and it can jointly estimate the number of targets and their states from a sequence of sensor measurement sets. However, because of the existence of systematic errors in sensor measurements, the CBMeMBer filter can easily produce different levels of performance degradation. In this paper, an extended CBMeMBer filter, in which the joint probability density function of target state and systematic error is recursively estimated, is proposed to address the MTT problem based on the sensor measurements with systematic errors. In addition, an analytic implementation of the extended CBMeMBer filter is also presented for linear Gaussian models. Simulation results confirm that the proposed algorithm can track multiple targets with better performance.
Combining Remote Temperature Sensing with in-Situ Sensing to Track Marine/Freshwater Mixing Dynamics
Authors: McCaul Margaret , Barland Jack , Cleary John , Cahalane Conor , McCarthy Tim , Diamond Dermot
Published: August 2016

The ability to track the dynamics of processes in natural water bodies on a global scale, and at a resolution that enables highly localised behaviour to be visualized, is an ideal scenario for understanding how local events can influence the global environment. While advances in in-situ chem/bio-sensing continue to be reported, costs and reliability issues still inhibit the implementation of large-scale deployments. In contrast, physical parameters like surface temperature can be tracked on a global scale using satellite remote sensing, and locally at high resolution via flyovers and drones using multi-spectral imaging. In this study, we show how a much more complete picture of submarine and intertidal groundwater discharge patterns in Kinvara Bay, Galway can be achieved using a fusion of data collected from the Earth Observation satellite (Landsat 8), small aircraft and in-situ sensors. Over the course of the four-day field campaign, over 65,000 in-situ temperatures, salinity and nutrient measurements were collected in parallel with high-resolution thermal imaging from aircraft flyovers. The processed in-situ data show highly correlated patterns between temperature and salinity at the southern end of the bay where freshwater springs can be identified at low tide. Salinity values range from 1 to 2 ppt at the southern end of the bay to 30 ppt at the mouth of the bay, indicating the presence of a freshwater wedge. The data clearly show that temperature differences can be used to track the dynamics of freshwater and seawater mixing in the inner bay region. This outcome suggests that combining the tremendous spatial density and wide geographical reach of remote temperature sensing (using drones, flyovers and satellites) with ground-truthing via appropriately located in-situ sensors (temperature, salinity, chemical, and biological) can produce a much more complete and accurate picture of the water dynamics than each modality used in isolation.
Carded Tow Real-Time Color Assessment: A Spectral Camera-Based System
Authors: Furferi Rocco , Governi Lapo , Volpe Yary , Carfagni Monica
Published: August 2016

One of the most important parameters to be controlled during the production of textile yarns obtained by mixing pre-colored fibers, is the color correspondence between the manufactured yarn and a given reference, usually provided by a designer or a customer. Obtaining yarns from raw pre-colored fibers is a complex manufacturing process entailing a number of steps such as laboratory sampling, color recipe corrections, blowing, carding and spinning. Carding process is the one devoted to transform a “fuzzy mass” of tufted fibers into a regular mass of untwisted fibers, named “tow”. During this process, unfortunately, the correspondence between the color of the tow and the target one cannot be assured, thus leading to yarns whose color differs from the one used for reference. To solve this issue, the main aim of this work is to provide a system able to perform a spectral camera-based real-time measurement of a carded tow, to assess its color correspondence with a reference carded fabric and, at the same time, to monitor the overall quality of the tow during the carding process. Tested against a number of differently colored carded fabrics, the proposed system proved its effectiveness in reliably assessing color correspondence in real-time.
Resonance Frequency of Optical Microbubble Resonators: Direct Measurements and Mitigation of Fluctuations
Authors: Cosci Alessandro , Berneschi Simone , Giannetti Ambra , Farnesi Daniele , Cosi Franco , Baldini Francesco , Nunzi Conti Gualtiero , Soria Silvia , Barucci Andrea , Righini Giancarlo , Pelli Stefano
Published: August 2016

This work shows the improvements in the sensing capabilities and precision of an Optical Microbubble Resonator due to the introduction of an encaging poly(methyl methacrylate) (PMMA) box. A frequency fluctuation parameter σ was defined as a score of resonance stability and was evaluated in the presence and absence of the encaging system and in the case of air- or water-filling of the cavity. Furthermore, the noise interference introduced by the peristaltic and the syringe pumping system was studied. The measurements showed a reduction of σ in the presence of the encaging PMMA box and when the syringe pump was used as flowing system.
Reconfiguring the Contours of Statehood and the Rights of Peoples of Disappearing States in the Age of Global Climate Change
Authors: Skillington Tracey
Published: August 2016

Many of the elements that have traditionally supported state level normative self-organization, most notably territory, are being actively undermined by rising sea levels, flooding, desertification, amongst other climate change effects. As more and more states come to be redefined as “disappearing”, that is, states losing their territories to the natural environment through no specific fault of their own, a question arises as to how displaced communities will be assisted in their desire (and right) to continue to practice principles of self-determination and self-government? What is clear is that the international community can no longer continue with the fiction of a unified or unchanging model of the liberal democratic state. Instead, alternative ontological models of sovereign community are required, as is a re-imagining of how statehood might be re-constituted in the future in response to deepening ecological problems. The international community must now begin to address the immanent nature of threats posed to disappearing states and consider how a model of statehood that does not privilege territory as a fixed component of state identity could be operationalized. This paper considers how a democratic reform of statehood might proceed and resettlement agreements for displaced communities determined. The transition to an era of peaceful sovereign relations under deteriorating global climate conditions and growing natural resource scarcity, it argues, will require a significant extension of established traditions of democratic compromise, human rights solidarity and cosmopolitan justice.
Sustainable Stormwater Management: Examining the Role of Local Planning Capacity in Mitigating Peak Surface Runoff
Authors: Kim Hyun , Li Ming-Han
Published: August 2016

The Chesapeake Bay, the largest estuary in the United States, is rich in natural resources. Its watershed has been impacted by excessive and degraded stormwater runoff from rapid urbanization. We used an empirical approach to investigate how local planning capacity in the Chesapeake Bay watershed affected stream flow. A multiple regression analysis was employed to examine to what extent that the planning factors and other contextual variables were associated with peak runoff. Counterintuitively, we found that sub-basins included in the sample jurisdictions with a relatively high plan quality score tend to generate higher volumes of peak runoff. Results further indicate that specific geographical, basin characteristic, and biophysical factors affected mean annual peak runoff significantly. Overall, our findings highlight the importance of local planning capacity and sustainable stormwater management concepts in mitigating excessive runoff.
Risk vs. Reward: A Methodology to Assess Investment in Marine Energy
Authors: Hutcheson John , De Andrés Adrián , Jeffrey Henry
Published: August 2016

The majority of WEC (wave energy converter) projects are expensive and pose a large risk to a developer. Currently no developers have been successful in commercialising a WEC. So far, many wave energy feasibility studies have only considered the LCOE (levelised cost of electricity), assessing investment in marine energy technologies from a purely financial point of view. No previous studies have, however, explicitly accounted for development risk as well as the LCOE to determine the feasibility of a project. This paper proposes a new methodology that can be used to account for both risk and the LCOE to give a clearer picture of the feasibility of a WEC development. By combining the LCOE and risk score for a particular development, the “value for risk” can be calculated, presented here as the “RR ratio” (“Risk/Reward ratio”). A number of case studies were chosen to test the model, investigating the RR ratio for a number of different WEC technologies and ranking them to suggest an optimal development path for the industry. Results showed that projects that combine many innovative technologies provide the best “value for risk”. These devices overall had the highest risk, suggesting that multiple developers are likely required to collaborate in order to reduce the risk down to acceptable levels for each.
The Conformal Camera in Modeling Active Binocular Vision
Authors: Turski Jacek
Published: August 2016

Primate vision is an active process that constructs a stable internal representation of the 3D world based on 2D sensory inputs that are inherently unstable due to incessant eye movements. We present here a mathematical framework for processing visual information for a biologically-mediated active vision stereo system with asymmetric conformal cameras. This model utilizes the geometric analysis on the Riemann sphere developed in the group-theoretic framework of the conformal camera, thus far only applicable in modeling monocular vision. The asymmetric conformal camera model constructed here includes the fovea’s asymmetric displacement on the retina and the eye’s natural crystalline lens tilt and decentration, as observed in ophthalmological diagnostics. We extend the group-theoretic framework underlying the conformal camera to the stereo system with asymmetric conformal cameras. Our numerical simulation shows that the theoretical horopter curves in this stereo system are conics that well approximate the empirical longitudinal horopters of the primate vision system.
Exposure Assessment of Infants to Aflatoxin M1 through Consumption of Breast Milk and Infant Powdered Milk in Brazil
Authors: Ishikawa Angélica , Takabayashi-Yamashita Cássia , Ono Elisabete , Bagatin Artur , Rigobello Fabiana , Kawamura Osamu , Hirooka Elisa , Itano Eiko
Published: August 2016

Aflatoxin M1 (AFM1) is an important biomarker that can be used to evaluate aflatoxin exposure in both humans and animals. The aim of this study was to evaluate the exposure degree of infants to AFM1 through consumption of breast milk and infant powdered milk in Brazil. For this purpose, the estimated daily intake (EDI) for infants was calculated based on the AFM1 levels analyzed in 94 breast milk (BM) samples collected in Southern Brazil, and 16 infant powdered milk (IPM) samples commonly commercialized in Brazil. AFM1 was detected in 5.3% (n = 5) and 43.8% (n = 7) of BM and IPM samples, with mean levels of 0.003 ng/g and 0.011 ng/g, respectively. All the IPM samples showed AFM1 levels lower than those established by the Brazilian guidelines (5 ng/g), and in most of the samples (81.25%) levels were below the maximum limit tolerated by the European Commission (0.025 ng/g). The EDI of AFM1 for infants aged zero to 12 months old showed values from 0.018 to 0.069 ng/kg body weight/day for BM, and 0.078 to 0.306 ng/kg body weight/day for IPM. Hazard index (HI) values for BM and IPM were less than one, except for IPM intended for infants up to one month. In conclusion, the exposure of infants to AFM1 was low, but continuous monitoring of mycotoxin levels is essential to minimize infant health risk.
The Teleparallel Equivalent of General Relativity and the Gravitational Centre of Mass
Authors: Maluf José
Published: August 2016

We present a brief review of the teleparallel equivalent of general relativity and analyse the expression for the centre of mass density of the gravitational field. This expression has not been sufficiently discussed in the literature. One motivation for the present analysis is the investigation of the localization of dark energy in the three-dimensional space, induced by a cosmological constant in a simple Schwarzschild-de Sitter space-time. We also investigate the gravitational centre of mass density in a particular model of dark matter, in the space-time of a point massive particle and in an arbitrary space-time with axial symmetry. The results are plausible, and lead to the notion of gravitational centre of mass (COM) distribution function.
Ehrlichioses: An Important One Health Opportunity
Authors: Saito Tais , Walker David
Published: August 2016

Ehrlichioses are caused by obligately intracellular bacteria that are maintained subclinically in a persistently infected vertebrate host and a tick vector. The most severe life-threatening illnesses, such as human monocytotropic ehrlichiosis and heartwater, occur in incidental hosts. Ehrlichia have a developmental cycle involving an infectious, nonreplicating, dense core cell and a noninfectious, replicating reticulate cell. Ehrlichiae secrete proteins that bind to host cytoplasmic proteins and nuclear chromatin, manipulating the host cell environment to their advantage. Severe disease in immunocompetent hosts is mediated in large part by immunologic and inflammatory mechanisms, including overproduction of tumor necrosis factor α (TNF-α), which is produced by CD8 T lymphocytes, and interleukin-10 (IL-10). Immune components that contribute to control of ehrlichial infection include CD4 and CD8 T cells, natural killer (NK) cells, interferon-γ (IFN-γ), IL-12, and antibodies. Some immune components, such as TNF-α, perforin, and CD8 T cells, play both pathogenic and protective roles. In contrast with the immunocompetent host, which may die with few detectable organisms owing to the overly strong immune response, immunodeficient hosts die with overwhelming infection and large quantities of organisms in the tissues. Vaccine development is challenging because of antigenic diversity of E. ruminantium, the necessity of avoiding an immunopathologic response, and incomplete knowledge of the protective antigens.
Causes of Domestic Water Consumption Trends in the City of Alicante: Exploring the Links between the Housing Bubble, the Types of Housing and the Socio-Economic Factors
Authors: Morote Álvaro-Francisco , Hernández María , Rico Antonio-Manuel
Published: August 2016

The European Mediterranean coastline has experienced major tourism-related urbanization since 1960. This is a dynamic that has led to increased spending on water consumption for urban and tourism-related uses. The objective of this paper is to define and to analyze how domestic water consumption in the city of Alicante evolved between 2000 and 2013. Real billing figures for individual households were analyzed according to the type of housing and the income level of the occupants. The conclusions drawn show that consumption fell over the period studied, and that there are different patterns in water expenditure depending on the type of housing and the inhabitants.
Nouvelle étude du Lokeśvara khmer du Musée national de Colombo (Sri Lanka)
Authors: Vincent Brice
Published: August 2016

Découvert et publié au début des années 1920 par Victor Goloubew, le Lokeśvara khmer du Musée national de Colombo reste un témoignage historique majeur des relations anciennement tissées entre le Cambodge et le Sri Lanka. C’est à ce titre qu’il nous paraît utile de réexaminer cette statuette en bronze : en prenant d’abord en compte des considérations d’ordre technique, iconographique et stylistique, puis en discutant en détail les conditions de sa découverte. Une telle approche aide notamment à mieux comprendre l’hypothèse de V. Goloubew, qui proposa d’identifier l’idole comme un ex-voto offert par le souverain khmer, et Roi lépreux « historique », Jayavarman VII. À la légende est toutefois préféré le contexte des interactions politiques et religieuses entretenues entre les royaumes khmer et singhalais à partir du milieu du XIIe siècle. Le long voyage de l’idole est ainsi attribué à un pèlerin bouddhiste, sans doute venu du Cambodge pour vénérer Avalokiteśvara en un sanctuaire local réputé et dédié au bodhisattva guérisseur.
TERRESTRIAL PLANET FORMATION FROM AN ANNULUS
Authors: Walsh Kevin J. , Levison Harold F.
Published: August 2016

It has been shown that some aspects of the terrestrial planets can be explained, particularly the Earth/Mars mass ratio, when they form from a truncated disk with an outer edge near 1.0 au. This has been previously modeled starting from an intermediate stage of growth utilizing pre-formed planetary embryos. We present simulations that were designed to test this idea by following the growth process from km-sized objects located between 0.7 and 1.0 au up to terrestrial planets. The simulations explore initial conditions where the solids in the disk are planetesimals with radii initially between 3 and 300 km, alternately including effects from a dissipating gaseous solar nebula and collisional fragmentation. We use a new Lagrangian code known as LIPAD, which is a particle-based code that models the fragmentation, accretion, and dynamical evolution of a large number of planetesimals, and can model the entire growth process from km-sizes up to planets. A suite of large (∼ Mars mass) planetary embryos is complete in only ∼1 Myr, containing most of the system mass. A quiescent period then persists for 10–20 Myr characterized by slow diffusion of the orbits and continued accretion of the remaining planetesimals. This is interrupted by an instability that leads to embryos crossing orbits and embryo–embryo impacts that eventually produce the final set of planets. While this evolution is different than that found in other works exploring an annulus, the final planetary systems are similar, with roughly the correct number of planets and good Mars-analogs.
ENSEMBLE LEARNING METHOD FOR OUTLIER DETECTION AND ITS APPLICATION TO ASTRONOMICAL LIGHT CURVES
Authors: Nun Isadora , Protopapas Pavlos , Sim Brandon , Chen Wesley
Published: August 2016

Outlier detection is necessary for automated data analysis, with specific applications spanning almost every domain from financial markets to epidemiology to fraud detection. We introduce a novel mixture of the experts outlier detection model, which uses a dynamically trained, weighted network of five distinct outlier detection methods. After dimensionality reduction, individual outlier detection methods score each data point for “outlierness” in this new feature space. Our model then uses dynamically trained parameters to weigh the scores of each method, allowing for a finalized outlier score. We find that the mixture of experts model performs, on average, better than any single expert model in identifying both artificially and manually picked outliers. This mixture model is applied to a data set of astronomical light curves, after dimensionality reduction via time series feature extraction. Our model was tested using three fields from the MACHO catalog and generated a list of anomalous candidates. We confirm that the outliers detected using this method belong to rare classes, like Novae, He-burning, and red giant stars; other outlier light curves identified have no available information associated with them. To elucidate their nature, we created a website containing the light-curve data and information about these objects. Users can attempt to classify the light curves, give conjectures about their identities, and sign up for follow up messages about the progress made on identifying these objects. This user submitted data can be used further train of our mixture of experts model. Our code is publicly available to all who are interested.
THE DISTANT OUTER GAS ARM BETWEEN l = 35° AND l = 45°
Authors: Su Yang , Sun Yan , Li Chong , Zhang Shaobo , Zhou Xin , Fang Min , Yang Ji , Chen Xuepeng
Published: August 2016

The Galactic plane has been mapped from l = 34.°75 to 45.°25 and b = −5.°25 to 5.°25 in the CO (J = 1–0) emission with the 13.7 m telescope of the Purple Mountain Observatory. The unbiased survey covers a large area of 110 square degrees sampled every 30″ with a velocity resolution of

. In this paper, we present the result of an unbiased CO survey of this longitude and latitude range in the velocity range from −60 to

. Over 500 molecular clouds (MCs) are picked out from the 12CO (J = 1–0) emission, and 131 of these MCs are associated with 13CO emission. The distant MCs, which lie beyond the solar circle and are mostly concentrated in the Galactic plane, trace the large-scale molecular gas structure over 10 degrees of Galactic azimuth. We find that the distribution of the distant MCs can be well fitted by a Gaussian function with a full width at half maximum (FWHM) of 0.°7 with the Galactic latitude. We suggest that the CO emission of the segment is from the Outer Arm. The physical mid-plane traced by the Outer Arm seems to be slightly displaced from the IAU-defined plane on a large scale, which could be explained by the warped plane at large Galactocentric distances of ≳10 kpc and the apparent tilted mid-plane to the projected IAU-defined plane caused by the Sun’s z-height above the disk for distances near and within the Solar circle. After removing the effect of the warp and tilted structure, the scale height of the MCs in the Outer Arm is about 0.°6 or 160 pc at a heliocentric distance of 15 kpc. If the inner plane of our Galaxy is flat, we can derive an upper limit of the Sun’s offset of ∼17.1 pc above the physical mid-plane of the Milky Way. We also discuss the correlations between the physical parameters of the distant MCs, which is quite consistent with the result of other studies of this parameter.
SUPRATHERMAL SOLAR WIND ELECTRONS AND LANGMUIR TURBULENCE
Authors: Kim Sunjung , Yoon Peter H. , Choe G. S. , moon Y.-J.
Published: August 2016

The steady-state model recently put forth for the solar wind electron velocity distribution function during quiet time conditions, was originally composed of three population electrons (core, halo, and superhalo) with the core remaining nonresonant with any plasma waves while the halo and superhalo separately maintained steady-state resonance with whistler- and Langmuir-frequency range fluctuations, respectively. However, a recent paper demonstrates that whistler-range fluctuations in fact have no significant contribution. The present paper represents a consummation of the model in that a self-consistent model of the suprathermal electron population, which encompasses both the halo and the superhalo, is constructed solely on the basis of the Langmuir fluctuation spectrum. Numerical solutions to steady-state particle and wave kinetic equations are obtained on the basis of an initial trial electron distribution and Langmuir wave spectrum. Such a finding offers a self-consistent explanation for the observed steady-state electron distribution in the solar wind.
FERMI STUDY OF 5–300 GeV EMISSION FROM THE HIGH-MASS PULSAR BINARY PSR B1259-63/LS 2883
Authors: Xing Yi , Wang Zhongxiang , Takata Jumpei
Published: August 2016

We report the results from our detailed analysis of the Fermi Large Area Telescope data for the pulsar binary PSR B1259−63/LS 2883. During the GeV flares that occurred when the pulsar was in the periastron passages, we have detected a 5–300 GeV component at ≃5σ in emission from the binary. The detection verifies the presence of the component that has been marginally found in previous studies of the binary. Furthermore, we have discovered that this component was marginally present even in the quiescent state of the binary, specifically the mean anomaly phase 0.7–0.9. The component can be described by a power law with a photon index Γ ∼ 1.4, and the flux in the flares is approximately one order of magnitude higher than that in quiescence. We discuss the origin of this component. It likely arises from the inverse-Compton process: due to the interaction between the winds from the pulsar and its massive companion, high-energy particles from the shock scatter the seed photons from the companion to GeV/TeV energies. Based on this scenario, model fits to the broad-band X-ray to TeV spectra of the binary in the flaring and quiescent states are provided.
Sexually transmitted infections case notification rates in the Kingdom of Saudi Arabia, 2005–2012
Authors: Memish Ziad A , Filemban Sanaa M , Al-Hakeem Raafat F , Hassan Majdy H , Al-Tawfiq Jaffar A
Published: August 2016

Introduction: Sexually transmitted infections (STIs) are major public health concerns around the world. This study describes the epidemiology of reported STI cases from 2005 to 2012 in the Kingdom of Saudi Arabia. Methodology: The annual registry was the main source of data as reported by healthcare providers. Case definitions were based on positive human immunodeficiency virus (HIV) antibodies detectable by enzyme-linked immunosorbent assay (ELISA) and confirmed by western blot test for HIV cases. The definitions of other STIs were based on published Centers for Disease Control and Prevention (CDC) definitions. Results: During the study period, 68,886 new cases were reported, with nongonococcal urethritis being the highest STI (25.4) per 100,000 population (25.4), followed by trichomoniasis (9.1), HIV (7), human papillomavirus (HPV) infection (2.9), and syphilis (1.3). The cases included nongonococcal urethritis (n = 35,613; 51.7%), trichomoniasis (n = 12,679; 18.4%), gonococcal urethritis (n = 3,006; 4.4%), syphilis (n = 1,769; 2.6%), HIV (n = 9,843; 14.3%), genital warts (n = 4,018; 5.8%), genital herpes (n = 1,508; 2.2%), and chancroid (n = 450; 0.7%). Saudi contribution to HIV cases increased from 28.9% in the preceding decade to 43.5% in the current study. Conclusions: Nongonococcal urethritis, trichomoniasis, and HIV were the most commonly reported STIs in the Kingdom of Saudi Arabia.
An outbreak of Serratia liquefaciens at a rural health center in The Gambia
Authors: Ikumapayi Usman Nurudeen , Kanteh Abdoulie , Manneh Jarra , Lamin Modou , Mackenzie Grant Austin
Published: August 2016

Introduction: Healthcare-associated infections (HAIs) are better documented in developed than in developing countries. There are emerging reports regarding the high frequency of HAIs in developing countries. We aimed to report an outbreak of an HAI caused by Serratia liquefaciens at a rural health center in The Gambia. Methodology: Following an abrupt increase in the isolation of S. liquefaciens in clinical samples, laboratory and clinical consumables, as well as staff, were screened for contamination with S. liquefaciens. Conventional microbiological techniques and biochemical identification tests were used. A phenotypic typing was achieved using the Kirby-Bauer antibiotic susceptibility method. Strategies to control the outbreak were implemented. Results: A total of 794 samples were processed during the outbreak; 44 (6%) grew S. liquefaciens. Five (25%) of the 20 suspected contaminated materials (hospital consumables and equipment) screened yielded growth of the organism. The primary source of the outbreak was hospital consumables. Three (7%) of the 44 infected children died with no other known cause than S. liquefaciens infection. Ninety-nine percent similarity of the antibiogram phenotypic typing suggests the isolates were from the same clonal origin. The outbreak was successfully controlled after the removal and sterilization of the respective contaminated fluids and equipment. Conclusions: This HAI was caused by poor practice in the preparation of medications for nebulization and intravenous infusion, hygiene practices, and a lack of awareness among staff about infection control. We recommend further studies to delineate the role played by HAIs in the developing world.
Estimated burden of fungal infections in Kenya
Authors: Guto John Abuga , Bii Christine C , Denning David W
Published: August 2016

Introduction: Kenya is a developing country with a high rate of tuberculosis (TB) and a moderate HIV infection burden. No estimate of the burden of fungal diseases in Kenya is published. Methodology: We used specific populations at risk and fungal infection frequencies from the literature to estimate national incidence or prevalence of serious fungal infections. Used sources were: 2010 WHO TB statistics, Kenya Acquired Immunodeficiency Syndrome (AIDS) Epidemic Update 2012, Kenya Facts and figures 2012, Kenya Demographic and Health Survey 2008-2009. Results: Of Kenya’s population of ~40 million, 43% are under 15 years old and approximately 594,660 Kenyan women get >4 episodes Candida vulvovaginitis annually (2,988/100,000). The HIV/AIDS population at risk of opportunistic infections (OI) is 480,000 and the OI estimates include 306,000 patients with oral thrush (768/100,000), 114,000 with oesophageal candidiasis (286/100,000), 11,900 with cryptococcal meningitis (29/100,000) and 17,000 patients with Pneumocystis pneumonia (42/100,000). Chronic pulmonary aspergillosis following TB has a prevalence of 10,848 cases (32/100,000). The adult asthma prevalence is 3.1% and assuming 2.5% have allergic bronchopulmonary aspergillosis then 17,696 (44/100,000) are affected.  Invasive aspergillosis, candidaemia and Candida peritonitis are probably uncommon. Tinea capitis infects 9.6% of children in Kenya, while fungal keratitis and otomycoses are difficult to estimate. Conclusion: At any one time, about 7% of the Kenyan population suffers from a significant fungal infection, with recurrent vaginitis and tinea capitis accounting for 82% of the infections. These estimates require further epidemiological studies for validation.
Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
Authors: García Elizabeth , Bianco María V , Blanco Federico C , Bigi Fabiana
Published: August 2016

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Polyphasic characterization of Bacillus species from anthrax outbreaks in animals from South Africa and Lesotho
Authors: Lekota Kgaugelo Edward , Hassim Ayesha , Mafofo Joseph , Rees Jasper , Muchadeyi Farai Catherine , Van Heerden Henriette , Madoroba Evelyn
Published: August 2016

Introduction: Bacillus anthracis is the causative agent of anthrax, a disease endemic in regions of Northern Cape Province and Kruger National Park of South Africa. Accurate identification of virulent B. anthracis is essential but challenging due to its close relationship with other members of B. cereus group. This study characterized B. anthracis and Bacillus species that were recovered from animals and the environment where animals died of anthrax symptoms in southern Africa using a polyphasic approach. Methodology: For this purpose, 3 B. anthracis and 10 Bacillus isolates were subjected to microbiology tests, BiologOmniLog identification system (Biolog), 16S ribosomal RNA (rRNA) sequence analysis, polymerase chain reaction (PCR) detection of protective antigen (pag) and capsule (cap) regions, and real-time PCR using hybridization probes targeting chromosomal, pag, and capC genes. Results: The Bacillus isolates were non-hemolytic, non-motile, and susceptible to penicillin, which is typical of B. anthracis, but resistant to gamma phage, unlike typical B. anthracis. The Biolog system and 16S rRNA gene sequence analysis identified most of the Bacillus isolates as B. endophyticus (7 of 10). Conventional PCR revealed that most of the Bacillus isolates contained capBCA gene regions. This highlights the limitation of the specificity of conventional PCR and the fact that the real-time PCR is more specific and reliable for anthrax diagnosis. Conclusions: Real-time PCR, 16S rRNA sequencing, and confirmatory microbiology tests including phage resistance distinguished Bacillus isolates from B. anthracis in this study. Identification of B. anthracis should be done using a polyphasic approach.
Uma matemática na ponta dos dedos com dispositivos touchscreen
Authors: Bairral Marcelo Almeida , Assis Alexandre Rodrigues de , Silva Bárbara C. C. da
Published: August 2016

Os recursos informáticos continuam crescendo e trazendo desafios a educação. O contínuo desenvolvimento das tecnologias digitais móveis propicia inovações nas práticas pedagógicas e promove reflexões sobre os impactos causados pelas mudanças. Esse artigo é parte de uma investigação interessada no uso de dispositivos com manipulação touchscreen direcionados para os processos de ensino e aprendizagem de matemática, particularmente em geometria.  Apresentaremos um levantamento de dispositivos touchscreen e os primeiros resultados de atividades desenvolvidas em dois softwares o Geometric Constructer (GC) e o Sketchometry, realizados no período de novembro de 2012 a outubro de 2013, focado na descrição e natureza desses dispositivos. Verificamos que os aplicativos (APPs) são de dois tipos: softwares e jogos. Escolhemos trabalhar com softwares, pois estes proporcionam ambientes com recursos livres para construções geométricas. Esse estudo serve de ponto de partida que pode auxiliar professores e pesquisadores interessados na inserção de dispositivos touchscreen em novas práticas educativas.
Uma proposta didática com abordagem CTS para o estudo dos gases e cinética química utilizando a temática da qualidade do ar interior
Authors: Oliveira Silvaney De , Guimarães Orliney Maciel , Lorenzetti Leonir
Published: August 2016

As propostas de abordagens que contemplam as interações ciênciatecnologia-sociedade (CTS) têm se mostrado como alternativa para um Ensino de Ciências que promova a Alfabetização Científica e Tecnológica (ACT) dos estudantes. Nessa perspectiva, desenvolvemos uma pesquisa qualitativa de natureza interpretativa através de uma intervenção pedagógica na disciplina de Química com uma turma do Ensino Médio de uma escola pública na região metropolitana de Curitiba-PR. A proposta didática de uma abordagem temática CTS foi construída a partir de uma série de parâmetros de ACT articulados com a temática da Qualidade do Ar Interior (QAI) e com os conteúdos disciplinares relativos ao Estudo dos Gases e a Cinética Química. Neste artigo, discutimos os pressupostos teóricos que amparam a referida proposta, descrevemos a sequência das aulas e explicitamos os parâmetros utilizados para sua construção e desenvolvimento. Consideramos que a proposta permite uma efetiva implementação de abordagens CTS a partir da temática analisada.
Concepções e Práticas Avaliativas no Estágio Supervisionado de Ciências e Biologia
Authors: Queiroz Amaral Anelize , Cutchma Taís Regina , Daneluz Débora , Miguel Kassiana , Battisti Lucas , Auache Filho Alexandre Augusto
Published: August 2016

Este trabalho faz parte de uma reflexão proposta na disciplina de Estágio Supervisionado do Curso de Licenciatura em Ciências Biológica, de uma universidade pública do Estado do Paraná, Brasil. Esta pesquisa objetivou diagnosticar concepções e práticas avaliativas, no sentido de apontar anseios e dúvidas dos alunos em formação inicial. Para tanto, foi aplicado um questionário para doze acadêmicos e em seguida os dados foram submetidos a uma análise quanti-qualitativa. Os dados analisados evidenciaram que o conceito de avaliação ainda necessita de uma reflexão que ultrapasse a visão de um processo puramente classificatório e burocrático, cujo o instrumento avaliativo mais utilizado é a prova escrita. Verificou-se que, após as discussões no decorrer da disciplina de Estágio Supervisionado  sobre as práticas avaliativas utilizadas, esse trabalho colaborou com uma melhor compreensão do processo avaliativo, sugerindo e instigando os futuros professores a reverem algumas concepções e práticas avaliativas em seu dia-a-dia.