bluuebunny/crossref_metadata_2025 huggingface dataset:
Getting a (big) data-based grip on ideological change. Evidence from Belgian Dutch
Authors: Grondelaers Stefan , Speelman Dirk , Lybaert Chloé , van Gent Paul
Published: May 2020

In this paper we introduce a computationally enriched experimental tool designed to investigate language ideology (change). In a free response experiment, 211 respondents returned three adjectives in reaction to the labels for five regional varieties, one ethnic variety and two supra-regional varieties of Belgian Dutch, as well as the standard accent of Netherlandic Dutch. Valence information (pertaining to the positive/negative character of the responses) and big data–based distributional analysis (to detect semantic similarity between the responses) were used to cluster the response adjectives into 11 positive and 11 negative evaluative dimensions. Correspondence analysis was subsequently used to compute and visualize the associations between these evaluative dimensions and the investigated language labels, in order to generate “perceptual maps” of the Belgian language repertoire. Contrary to our expectations, these maps unveiled not only the dominant value system which drives standard usage, but also the competing ideology which frames the increasingly occurring non-standard forms. In addition, they revealed a much richer stratification than the “one variety good, all other varieties bad” dichotomy we had anticipated: while VRT-Dutch remains the superior (albeit increasingly virtual) standard for Belgian Dutch, the stigmatized colloquial variety Tussentaal is gradually being accepted as a practical lingua franca, and the Ghent-accent is boosted by modern prestige (dynamism) features. Even more crucially, separate perceptual maps for the older and younger respondents lay bare generational change: there is a growing conceptual proximity between VRT-Dutch and Tussentaal in the younger perceptions.
Cosmogenic10Be and36Cl geochronology of cryoplanation terraces in the Alaskan Yukon-Tanana Upland
Authors: Nyland Kelsey E. , Nelson Frederick E. , Figueiredo Paula M.
Published: May 2020

Cryoplanation terraces are prominent but enigmatic landforms found in present and past periglacial environments. Geomorphologists have debated for more than a century over processes involved in the formation of these elevated, step-like, bedrock features. Presented here are the first numerical surface exposure ages and scarp retreat rates from cryoplanation terraces in the Yukon-Tanana Upland (YTU) in Alaska, part of unglaciated eastern Beringia, obtained from terrestrial cosmogenic nuclides (TCN) in surface boulders. Ages comprise six10Be TCN ages from two terrace treads near Eagle Summit and six36Cl ages from two treads on Mt. Fairplay. Based on these exposure ages, scarps at both locations were last actively eroding from 49 to 22.4 ka. Both locations exhibit time-transgressive development, particularly near scarp-tread junctions. Boulder exposure ages and distances between sampled boulder locations were used to estimate scarp retreat rates of 0.11 to 0.56 cm/yr. These numerical exposure ages presented here demonstrate that the cryoplanation terraces in the YTU are diachronous surfaces actively eroding during multiple cold intervals. With these results, hypotheses for cryoplanation terrace formation are discussed and evaluated for the YTU, including those based on geologic structure, nivation, and the influence of permafrost.
Dietary patterns and relative expression levels of PPAR-γ, VEGF-A and HIF-1α genes in benign breast diseases: case–control and consecutive case-series designs
Authors: Asemani Sanaz , Montazeri Vahid , Foroutan-Ghaznavi Mitra , Pirouzpanah Seyed-Sajjad , Baradaran Behzad , Jafari Sahar , Barzegar Ali , Shanehbandi Dariush , Asadi Nahideh , Pirouzpanah Saeed
Published: May 2020

We aimed to study dietary patterns in association with the relative expression levels of PPAR-γ, vascular endothelial growth factor-A (VEGF-A) and hypoxia-inducible factor-1α (HIF-1α) in women with benign breast disease (BBD). The study design was combinative, included a case-series and case–control compartments. Initially, eligible BBD patients (n 77, aged 19–52 years old) were recruited at Nour-Nejat hospital, Tabriz, Iran (2012–2014). A hospital-based group of healthy controls was matched for age (n 231, aged 20–63 years old) and sex. Dietary data were collected using a valid 136-item FFQ. Principal component analysis generated two main components (Kaiser–Meyer–Olkin = 0·684), including a Healthy pattern (whole bread, fruits, vegetables, vegetable oils, legumes, spices, seafood, low-fat meat, skinless poultry, low-fat dairy products, nuts and seeds) and a Western pattern (starchy foods, high-fat meat and poultry, high-fat dairy products, hydrogenated fat, fast food, salt and sweets). High adherence to the Western pattern increased the risk of BBD (ORadj 5·59; 95 % CI 2·06, 15·10; P < 0·01), whereas high intake of the Healthy pattern was associated with a 74 % lower risk of BBD (95 % CI 0·08, 0·81; P < 0·05). In the BBD population, the Western pattern was correlated with over-expression of HIF-1α (radj 0·309, P < 0·05). There were inverse correlations between the Healthy pattern and expressions of PPAR-γ (radj −0·338, P < 0·05), HIF-1α (radj −0·340, P < 0·05) and VEGF-A (radj −0·286, P < 0·05). In conclusion, new findings suggested that the Healthy pattern was associated inversely with the risk of BBD, and this could be correlated with down-regulation of PPAR-γ, VEGF-A and HIF-1α genes, which might hold promise to preclude BBD of malignant pathological transformation.
Appraisal of nitric oxide priming to improve the physiology of bread wheat
Authors: Bibi Asia , Qureshi Sadia , Shehzadi Iram , Amjad Muhammad Shoaib , Azhar Nosheen , Batool Tahira , Firdous Sadiqa , Khan Muhammad , Shokat Sajid
Published: May 2020

Seed priming is a pre-sown treatment and it is often used to improve the performance of plants in any environment, especially germination. In the current study, various concentrations of nitric oxide (NO) were used to evaluate its role for the induction of physiological variations within seven different wheat (Triticum aestivum L.) genotypes. Two experiments were conducted during 2013 and 2014 and the data were statistically analysed for significance. All these genotypes after treatment with sodium nitroprusside (SNP) as NO donor at 10−4 and 10−5 M concentrations were sown following randomized complete block design with triplicates in the fields of District Muzaffarabad, Pakistan. The concentration of NO at 10−4 M showed promising results and most of the studied characters were found improved compared to control. Wheat varieties primed with 10−4 M SNP showed highest germination speed and germination percentage. NARC-2011 and Uqab-2002 showed much improvement in physiological attributes at both concentrations of NO priming. However, Uqab-2002 and Punjab-2011 showed a significant increase in chlorophyll contents and leaf moisture content with 10−4 and 10−5 M SNP priming compared to control. Highest relative water content was observed within unprimed Lasani, whereas the relative injury was found to be decreased at 10−4 M SNP primed Faisalabad-2008. Wheat varieties Punjab-2011 and Faisalabad-2008 showed the highest increase in grain yield and biological yield by 10−4 M SNP. Hence, it is concluded that sowing of crops after priming at 10−4 M NO concentration can improve the germination, biochemistry and physiology that ultimately lead to an increase in crop yield.
The role of homofermentative and heterofermentative lactic acid bacteria for alfalfa silage: a meta-analysis
Authors: Blajman J. E. , Vinderola G. , Páez R. B. , Signorini M. L.
Published: May 2020

Lactic acid bacteria (LAB) are usually employed as alfalfa silage inoculants to obtain high-quality feed for animal husbandry. However, the effects of these inoculants are still unclear and need to be studied extensively. Therefore, the objective of this meta-analysis was to quantitatively summarize published research studies that assess the effects of homofermentative (HoLAB) and heterofermentative lactic acid bacteria (HeLAB) on fermentation parameters, nutritive value, microbiological composition and aerobic stability of alfalfa silage. PubMed, ScienceDirect and Scopus have been screened for articles published from 1980 to 2018. The criteria for inclusion were: randomized and controlled trials using alfalfa silage and published in peer-reviewed journals. It was found that inoculation with LAB decreased silage pH, neutral detergent fibre, acid detergent fibre and ammoniacal nitrogen, while it increased dry matter and crude protein compared to control in the pooled raw mean difference random-effect model. Additionally, LAB inoculation decreased acetate, propionate, ethanol and butyrate concentrations, whereas it increased lactate. In addition, inoculants reduced the counts of yeasts and moulds. Lastly, LAB inoculation improved aerobic stability. To the best of our knowledge, this is the first meta-analysis that aims at comparing the application of HoLAB and HeLAB for alfalfa silage. In the pool estimate, positive effects attributable to the application of microbial silage inoculants were found in most of the evaluated parameters; supporting the importance of applying both types of inoculants to improve forage preservation for the livestock industry.
Internal Labor Markets, Wage Convergence, and Investment
Authors: Silva Rui C.
Published: May 2020

I document wage convergence in conglomerates using detailed plant-level data: Workers in low-wage industries collect higher-than-industry wages when the diversified firm also operates in high-wage industries. I confirm this effect by exploiting the implementation of the North American Free Trade Agreement (NAFTA) and changes in minimum wages at the state level as sources of exogenous increases in wages in some plants. I then track the evolution of wages of the remaining workers of the firm, relative to workers of unaffiliated plants. Plants where workers collect higher-than-industry wages operate with higher capital intensity, suggesting that internal labor markets may affect investment decisions in internal capital markets.
Baltic cod endohelminths reflect recent ecological changes
Authors: Setyawan A.C. , Jensen H.M. , Kania P.W. , Buchmann K.
Published: May 2020

We suggest helminthological investigations of cod as a supplement to traditional biological and hydrographical methods for elucidation of ecological changes in the Baltic Sea. It is under discussion if oxygen deficit or seal abundance should explain the present critical situation of Baltic cod. A comparative investigation of endoparasitic helminths in Baltic cod (Gadus morhua), captured in the same marine habitat with an interval of 35 years (1983/2018) recorded 11 species of helminths comprising trematodes (Hemiurus luehei, Podocotyle atomon, Lepidapedon elongatum), nematodes (Contracaecum osculatum, Hysterothylacium aduncum, Capillaria gracilis, Cucullanus cirratus), cestodes (Bothriocephalus sp.) and acanthocephalans (Echinorhynchus gadi, Pomphorhynchus laevis, Corynosoma semerme). Significant prevalence and intensity increases were recorded for third-stage larvae of the nematode C. osculatum (liver location) and larvae of C. semerme (encapsulated in viscera). Both parasite species use grey seal as their final host, indicating the recent expansion of the Baltic seal population. A lower E. gadi intensity and an increased prevalence of L. elongatum of small cod (31–40 cm body length) suggest a lowered intake of amphipods (intermediate host) and elevated ingestion of polychaetes, respectively, but no significant changes were seen for other helminths.
ON SEVERAL PROPERTIES OF A CLASS OF PREFERENTIAL ATTACHMENT TREES—PLANE-ORIENTED RECURSIVE TREES
Authors: Zhang Panpan
Published: May 2020

In this paper, several properties of a class of trees presenting preferential attachment phenomenon—plane-oriented recursive trees (PORTs) are uncovered. Specifically, we investigate the degree profile of a PORT by determining the exact probability mass function of the degree of a node with a fixed label. We compute the expectation and the variance of degree variable via a Pólya urn approach. In addition, we study a topological index, Zagreb index, of this class of trees. We calculate the exact first two moments of the Zagreb index (of PORTs) by using recurrence methods. Lastly, we determine the limiting degree distribution in PORTs that grow in continuous time, where the embedding is done in a Poissonization framework. We show that it is exponential after proper scaling.
A conceptual tool for environmentally benign design: development and evaluation of a “proof of concept”
Authors: Acharya Shakuntala , Chakrabarti Amaresh
Published: May 2020

Design is a decision-making process for which knowledge is a prerequisite. Most decisions are taken at the conceptual stage and have pronounced influence on the final design. The literature, therefore, recommends the incorporation of sustainability criteria, such as environment, at this stage. Difficulty in performing life cycle assessment (LCA) due to low availability of information at the conceptual stage for evaluation and highly abstract nature of solutions, inadequate incorporation of DfE (Design for Environment) guidelines and LCA reports into the design process, and a lack of effective communication of the same to the designers for prompt decision-making are major motivations for the development of a support. This paper discusses a “conceptual Tool for environmentally benign design” – concepTe – that supports designers in decision-making during the conceptual design stage, by offering environmental impact (EI) estimates of abstract solutions with associated uncertainty, for evaluation and selection of the most environmentally benign solution as concept. The EI estimates are calculated by a module in the tool based on a proposed EI estimation method, which requires the support of a knowledge base to fetch appropriate LCA information corresponding to the design element being conceptualized. This knowledge base is grounded in the domain-agnostic SAPPhIRE model ontology, allows semantic operability of the knowledge, and offers the results to the designers in a familiar domain language to aid decision-making. A “proof of concept” of the tool is developed for application in design of building in the AEC (Architectural design, Engineering, and Construction) domain. Further, empirical studies are conducted to evaluate the effectiveness of the “proof of concept” to support decision-making and results are found favorable. The paper also discusses the future scope for further development of the tool into a holistic design decision-making platform.
Beyond binaries. Interrogating ancient DNA
Authors: Crellin Rachel J. , Harris Oliver J.T.
Published: May 2020

In this paper we explore ancient DNA (aDNA) as a powerful new technique for archaeologists. We argue that for aDNA to reach its full potential we need to carefully consider its theoretical underpinnings. We suggest that at present much aDNA research rests upon two problematic theoretical assumptions: first, that nature and culture exist in binary opposition and that DNA is a part of nature; second, that cultures form distinct and bounded identities. The nature–culture binary, which underpins much aDNA research, not only is a misunderstanding of our world but also results in placing archaeology and material culture in a secondary and subservient position to science and aDNA. Viewing cultures as distinct and bounded creates exclusionary, simplistic and singular identities for past populations. This stands in contrast to the work of social scientists, which has revealed identity to be complex, multiple, changing and contradictory. We offer a new way forward drawing upon assemblage thinking and post-humanism. This allows us to consider the messy and complex nature of our world and of human identities, and demands that we expect equally messy and complex results to emerge when we bring aDNA into conversation with other forms of archaeological evidence.
Deep Neural Network Enabled Space Group Identification in EBSD
Authors: Kaufmann Kevin , Zhu Chaoyi , Rosengarten Alexander S. , Vecchio Kenneth S.
Published: May 2020

Electron backscatter diffraction (EBSD) is one of the primary tools in materials development and analysis. The technique can perform simultaneous analyses at multiple length scales, providing local sub-micron information mapped globally to centimeter scale. Recently, a series of technological revolutions simultaneously increased diffraction pattern quality and collection rate. After collection, current EBSD pattern indexing techniques (whether Hough-based or dictionary pattern matching based) are capable of reliably differentiating between a “user selected” set of phases, if those phases contain sufficiently different crystal structures. EBSD is currently less well suited for the problem of phase identification where the phases in the sample are unknown. A pattern analysis technique capable of phase identification, utilizing the information-rich diffraction patterns potentially coupled with other data, such as EDS-derived chemistry, would enable EBSD to become a high-throughput technique replacing many slower (X-ray diffraction) or more expensive (neutron diffraction) methods. We utilize a machine learning technique to develop a general methodology for the space group classification of diffraction patterns; this is demonstrated within the $\lpar 4/m\comma \;\bar{3}\comma \;\;2/m\rpar$ point group. We evaluate the machine learning algorithm's performance in real-world situations using materials outside the training set, simultaneously elucidating the role of atomic scattering factors, orientation, and pattern quality on classification accuracy.
Secular evolution and pseudo-bulges
Authors: Combes Francoise
Published: May 2020

Through vertical resonances, bars can produce pseudo-bulges, within secular evolution. Bulges and pseudo-bulges have doubled their mass since z=1. The frequency of bulge-less galaxies at z=0 is difficult to explain, especially since clumpy galaxies at high z should create classical bulges in all galaxies. This issue is solved in modified gravity models. Bars and spirals in a galaxy disk, produce gravity torques that drive the gas to the center and fuel central star formation and nuclear activity. At 0.1-1kpc scale, observations of gravity torques show that only about one third of Seyfert galaxies experience molecular inflow and central fueling, while in most cases the gas is stalled in resonant rings. At 10-20pc scale, some galaxies have clearly revealed AGN fueling due to nuclear trailing spirals, influenced by the black hole potential. Thanks to ALMA, and angular resolution of up to 80mas, it is possible to reach the central black hole (BH) zone of influence, discover molecular tori, circum-nuclear disks misaligned with the galaxy, and the BH mass can be derived more directly from the kinematics.
Proper motion of the Magellanic Bridge: Removal of foreground stars
Authors: Schmidt Thomas , Cioni Maria-Rosa L. , Niederhofer Florian , Diaz Jonathan , Queiroz Anna B. A. , Matijevic Gal , Chiappini Cristina
Published: May 2020

The Large and Small Magellanic Cloud (LMC and SMC) are the most luminous dwarf galaxy satellites of the Milky Way. Thanks to their close proximity (50-60 kpc), they provide one of the best opportunities to study in detail the kinematics of resolved stellar populations in an interacting pair of galaxies. Large photometric surveys like the ongoing Gaia mission and the near-infrared VISTA survey of the Magellanic Cloud system (VMC) will have a significant impact on our insight into the Magellanic system. We have combined the individual strengths of VMC and Gaia DR2 data to improve our understanding of the internal kinematics of the galaxies. In this study, we present results from our ongoing project dedicated to measure and analyse the proper motions of large samples of stars across the Magellanic Clouds, efficiently removing Milk Way foreground stars utilising distances derived with the StarHorse code.
Effect of the gas percentage on the thickness of the galactic discs during minor mergers using hydrodynamical simulations
Authors: Thakkalapally Swetha , Hasan Priya , Hasan S. N.
Published: May 2020

We study the minor mergers of galaxies using simulations. For this we use GADGET2 code. We present results of simulations of minor mergers of disc galaxies of mass ratio 1:10. These simulations consist of collisionless as well as hydrodynamical runs including a gaseous component in the galactic disc of primary galaxy. Our goal is to establish the characteristics of discs obtained after the merger.We observe that the primary galaxy discs are not destroyed after the merger. We take different initial conditions for the primary galaxy varying the gas percentage in disc from 0–40 percentage and study the thickness of the disc after the merger. We generally observe that the thickness of the disc increases after the merger for any gas percentage. We also observe that as the gas percentage increases in the disc of initial primary galaxy, the increase in the thickness keeps decreasing.
Constraining the Milky Way non-axisymmetries with Gaia
Authors: Famaey B. , Monari G. , Siebert A. , Bienaymé O. , Ibata R. , Wegg C. , Gerhard O.
Published: May 2020

The unprecedented amount and accuracy of kinematic data from the second release of the Gaia mission have started revolutionizing our understanding of the dynamics of the Milky Way disk. The detailed stellar velocity field in the Galactic disk should allow us to constrain with unprecedented precision the parameters of the non-axisymmetric modes of the disk. We present here the status of our current modelling efforts in this area, and their implication on the dynamics of the Galactic bar in particular.
Measuring torque of galactic bar from Gaia DR2
Authors: Kipper Rain , Tempel Elmo
Published: May 2020

Since past few decades, observations have improved so strongly that when modelling Milky Way (MW) dynamics it is required to include small perturbations to the modelling process. It is difficult task that we try to solve by selecting regions to model so small that the perturbation can be considered to give nearly constant effect. We use Solar Neighbourhood (SN) as our test sample and assume that the bar effects show more or less constant contribution to SN. By extrapolating and smoothing observed stars on their orbits, and requiring that smoothed and observed phase space are consistent we were able to deduce acceleration vector. We conclude from non-radial acceleration component that the bar must cause about one third of total acceleration near SN.
New structures of the Milky Way stellar and dark halos revealed from the Subaru/Hyper Suprime-Cam survey
Authors: Chiba Masashi
Published: May 2020

We present the recent discovery of new halo structures in the Milky Way (MW) based on the Hyper Suprime-Cam (HSC) Subaru Strategic Program (SSP). HSC is a wide-field imager installed at the prime focus of the Subaru Telescope, and a 300-night survey with this instrument is being carried out in this program. The combination of the superb image quality and depth and the fact that it is a multi-band survey allows us to identify new faint satellites as well as field halo stars in the outskirts of the MW halo beyond the reach of previous surveys. We report here on the new insights into the nature of both stellar and dark halos in the MW as revealed from this on-going survey program and show prospects based on the upcoming large spectroscopic survey with Subaru Prime Focus Spectrograph.
Tracing the rotational velocity of the halo with K-giant stars in LAMOST-Gaia era
Authors: Tian Hao , Liu Chao , Xu Yan , Xue Xiang-Xiang
Published: May 2020

LAMOST has obtained a large number of spectra for K-giant stars whose metallicities are well measured and released in DR5. Combining with the distances, radial velocities and proper motions provided by Gaia DR2, the full position and velocity information has been obtained. Using the Bayesian method we have constrained the rotational velocity of the halo and thick disk components in the local volume within 4 kpc from the Sun. The values of the rotational velocity are and for the halo and disk respectively, with the velocity of LSR assumed to be 232 km s−1. The dispersions of the rotational velocity are and for the two components. What’s more, another hot retrogradely rotating component is discovered.
VVV Microlensing events in the far side of the Milky Way
Authors: Gabriela Navarro María , Minniti Dante , Ramos Rodrigo Contreras
Published: May 2020

In order to study the most reddened areas of the Milky Way we used near-IR data from the VVV Survey. For the first time, the VISTA telescope allows us to observe the mid-plane through the Galactic bulge and study the disk in the other side of the Milky Way. Motivated by the detection of hundreds of microlensing events in the inner regions of the Galaxy, we propose three new configurations of microlensing events, placing the sources in the far-disk and the lenses in the far-disk/bulge/near-disk. These new configurations will change the usual way to interpret the timescale distributions due to the different populations along the line of sight, that exhibit varied transverse velocities and relative distances.
Galactic dynamics and DM profile of NGC1380 with ALMA and VLT/MUSE
Authors: Tsukui Takafumi , Iguchi Satoru , Onishi Kyoko
Published: May 2020

In order to understand the interaction between dark matter and baryonic matter in the galaxy evolution history, it is fundamental to constrain dark matter (DM) distribution in galaxies. However, it is difficult to constrain DM profile in the central region of early type galaxy because of the lack of extended neutral hydrogen gas and the degeneracy between dynamical stellar M/L and DM profile. To resolve this difficulty, we conducted combined analysis of ALMA cold molecular gas kinematics and MUSE stellar kinematics of early type fast rotator galaxy NGC1380. In addition, we used HST image to trace the stellar luminosity distribution. With the help of high resolution of ALMA image and large field of view of MUSE, we derived the central BH mass, stellar bulge, disk and DM profile.
SiO maser emission as a stellar line-of-sight velocity tracer in the Bulge Asymmetries and Dynamical Evolution (BAaDE) survey
Authors: Stroh Michael C. , Pihlström Ylva M. , Sjouwerman Loránt O. , Lewis Megan O. , Claussen Mark J , Morris Mark R. , Rich R. Michael ,   the BAaDE collaboration
Published: May 2020

The Bulge Asymmetries and Dynamical Evolution (BAaDE) survey aims to explore the complex structure of the inner Galaxy and Galactic Bulge, by using the 43 GHz receivers at the Karl G. Jansky Very Large Array (VLA) and the 86 GHz receivers at the Atacama Large Millimeter/submillimeter Array (ALMA) to observe SiO maser lines in red giant stars. The goal is to construct a sample of stellar point-mass probes that can be used to test models of the gravitational potential, and the final sample is expected to provide at least 20,000 line-of-sight velocities and positions. A possible bias between the VLA and the ALMA SiO maser lines is explored, and the 86 GHz SiO line-peak velocities agree using either of the four sampled lines. Additionally, the SiO maser velocities agree with the OH maser derived velocities.
Elliptical galaxies/stellar halos connection
Authors: Arnaboldi Magda , Pulsoni Claudia , Gerhard Ortwin ,   the ePN.S team
Published: May 2020

Cosmological simulations predict that early-type galaxies (ETGs) are the results of extended mass accretion histories. The latter are characterized by different numbers of mergers, mergers’ mass ratios and gas fractions, and timing. Depending on the sequence and nature of these mergers that follow the first phase of the in-situ star formation, these accretion histories may lead to ETGs that have low or high mass halos, and that rotate fast or slow. Since the stellar halos maintain the fossil records of the events that led to their formation, a discontinuity may be in place between the inner regions of ETGs and their outer halos, because the time required for the halos’ stars to exchange their energies and momenta is very long compared with the age of these systems. Exquisite deep photometry and extended spectroscopy for significant samples of ETGs are then used to quantify the occurrence and significance of such a transition in the galaxies’ structural and kinematical parameters. Once this transition radius is measured, its dependency with the effective radius of the galaxies’ light distribution and total stellar masses can be investigated. Such correlations can then be compared with the predictions of accreted, i.e. ex-situ vs. in-situ components from cosmological simulations to validate such models.
Transnational Corporate Liability for Environmental Damage and Climate Change: Reassessing Access to Justice afterVedantav.Lungowe
Authors: Varvastian Samvel , Kalunga Felicity
Published: May 2020

On 10 April 2019 the Supreme Court of the United Kingdom delivered judgment in the case ofVedantav.Lungowe, which concerned the liability of an English company for environmental damage caused by its subsidiary in Zambia. The decision confirms that English parent companies can owe a duty of care to foreign claimants affected by operations of their subsidiaries abroad and that the English courts may have jurisdiction to hear such cases, even when a foreign court is a more appropriate place for the trial. It establishes an important precedent for providing access to justice for foreign claimants in transnational corporate liability litigation. Given the global presence of English companies and the fact that their foreign subsidiaries have been involved in multiple cases of environmental damage in the host states, the decision could give an impetus to future claims being brought in the English courts. Also, the decision opens some interesting possibilities for climate change liability litigation against English parent companies and their foreign subsidiaries, as their cumulative greenhouse gas emissions are likely to be considerably higher than when taken separately, arguably making prospective claims against them more viable.
Perjury in Early Tudor England
Authors: Cavill Paul
Published: May 2020

The break with Rome was enforced through a nationwide programme of oath-taking. The Henrician regime resorted to oaths because they were already fundamental to the functioning of the polity. In the preceding half-century, activities as diverse as heresy prosecution, tax assessment and debt litigation depended upon oaths. Irrespective of their often mundane subject matter, oaths were held to be religious acts. Prolific oath-taking, however, led to frequent oath-breaking. Perjury was therefore a more pressing and broader concept than it is today. It was an offence against God, against oneself and against others. How this crime was prosecuted and punished sheds light on the intersection of religious doctrine, legal systems and social practice in pre-Reformation England. An analysis of perjury also draws attention to a jurisdictional shift that was underway before the Reformation. In 1485, church courts had exercised an extensive cognizance of perjury; by 1535, they no longer did. The most important factor contributing to this decline in ecclesiastical jurisdiction was the constraint imposed by common lawyers on what cases the church courts could hear. Common law defined the crime of perjury more narrowly than did canon law. Hence the contraction of the church's jurisdiction would alter how perjury was perceived.
Conscience and the King's Household Clergy in the Early Tudor Court of Requests
Authors: Flannigan Laura
Published: May 2020

The early Tudor Court of Requests was closely attached to the king's person and his duty to provide ‘indifferent’ justice. In practice, however, it was staffed by members of the attendant royal household and council. Utilizing the little-studied but extensive records of the court, this article traces the rising dominance of the dean of the Chapel Royal and the royal almoner as administrators and judges there from the 1490s to the 1520s. It examines the relationship between supposedly ‘secular’ and ‘spiritual’ activities within the central administration and between the formal and informal structures and ideologies of the church, the law and the royal household. It explores the politics of proximity and the ad hoc nature of early Tudor governance which made the conscience-based jurisdiction in Requests especially convenient to the king and desperate litigants alike. Overall the article argues that although the influence of clergymen in the court waned towards the end of the sixteenth century in favour of common-law judges, its enduring association with ‘poor men's causes’ and ‘conscience’ grew directly from these early clerical underpinnings.
Protestant Dissent and the Law: Enforcement and Persecution, 1662–72
Authors: Wykes David L.
Published: May 2020

Religious Dissent was shaped by the law. The Act of Uniformity (1662) set out the terms of conformity, and those who could not accept those terms risked prosecution. A great many were convicted under the earlier Elizabethan and Jacobean recusancy statutes, but new laws, such as the Conventicle Acts (1664, 1670) and the Five Mile Act (1665), were also passed. Anthony Fletcher's essay, published in 1984, remains almost the only study of enforcement, in which he argued that the impact of the penal laws on Dissent has been exaggerated because the Conventicle Acts were not systematically enforced. A range of contemporary accounts will be used to suggest that their impact was greater than has been appreciated because of the enforcement of other statutes and the harassment of ejected ministers and their supporters.
A Motivational Framework for Psychopathy: Toward a Reconceptualization of the Disorder
Authors: Groat Lindsay L. , Shane Matthew S.
Published: May 2020

Abstract. The link between psychopathy and violence has been well documented. Estimates suggest psychopathic offenders are responsible for as much as 40% of violence-related crime, and that they show rates of violent recidivism up to five times higher than non-psychopathic offenders. Existing theories of the disorder argue that this violence stems from a core insensitivity to emotional/aversive information, or from a core inability to optimally allocate processing resources in complex environments. However, some newer findings have been difficult for existing theories to assimilate; moreover, successful treatment programs based off current conceptualizations have been slow to develop. With this in mind, the current paper proposes a new motivational framework for psychopathy, within which the disorder is conceptualized as stemming from more strategic, motivated processes. The paper begins by reviewing traditional theories of psychopathy and highlighting their explanatory strengths and limitations. The proposed motivational framework is then outlined, and a supportive rationale for the framework provided. Next, the paper undertakes a selective review of some of the most empirically supported features of the disorder, to highlight how these features may be productively reformulated within a motivational framework. Finally, the paper suggests several methods through which an empirical evaluation of the proposed ideas may be undertaken, and explores potential implications of a motivational framework for next-generation rehabilitation and treatment opportunities.
Crustal Structure in Southeastern Texas From Joint Inversion of Ambient Seismic Noise and P to S Receiver Functions
Authors: Porritt R. W. , Savvaidis A. , Young B. , Shirley M. , Li P.
Published: May 2020

The detection and classification of earthquakes in regions previously considered aseismic has led to significant advances in our understanding of anthropogenically induced earthquakes in productive basins. The Eagle Ford of southeastern Texas is one such basin that has seen an increase in earthquakes, and a recent TexNet temporary network was deployed in this region to better detect and locate earthquakes. Here we present new results from a joint inversion of ambient noise‐derived group and phase velocity maps with P to S receiver functions for shear velocity. The first‐order features of this model include a clear velocity contrast parallel to the Ouachita‐Marathon Front and thickening of the low‐velocity upper crust from the northwest toward the Gulf Coast. Secondary features include NE‐SW striking variations in the middle to upper crust, related to isolated uplifts inferred throughout the region, and variations in the presence and thickness of a high‐velocity lower crust. These features are anticorrelated such that the region of high‐velocity upper crust has little lower crust high‐velocity material. The Luling Uplift is identified as one of these features, and we suggest the variations in lower crust structure indicate along‐strike variations in the processes involved in the formation and subsequent breakup of Pangea. This model suggests the United States‐Gulf of Mexico margin morphology is shaped by deformation around the edges of strong blocks and that induced seismicity is focused by these structurally competent features.
Surrogate‐Based Joint Estimation of Subsurface Geological and Relative Permeability Parameters for High‐Dimensional Inverse Problem by Use of Smooth Local Parameterization
Authors: Xiao Cong , Tian Leng
Published: May 2020

This paper introduces an efficient surrogate model with the aim of accelerating joint estimation of subsurface geological properties and relative permeability parameters for high‐dimensional inversion problems. We fully replace the high‐fidelity model with a set of subdomain linear models through integrating model linearization with smooth local parameterization where the Gaussian geological parameters and non‐Gaussian facies indicators are locally parameterized. These subdomain linear models with smooth local parameterization, referred to as SLM‐SLP, are constructed in each subdomain individually using only a few high‐fidelity model simulations. An adaptive scheme, that is, weighting smooth local parameterization (WSLP), is introduced as well to mitigate the negative effects of inappropriate domain decomposition schemes by adaptively optimizing the domain decomposition strategy. The computational advantages of the proposed algorithm are demonstrated on a synthetic non‐Gaussian facies model and a real‐world high‐dimensional Gaussian model. The amount of computational cost has been drastically reduced while reasonable accuracy remains. Specifically, SLM‐SLP only needs 220 fidelity simulations to optimize 302 parameters. Compared to ensemble smoother with multiple data assimilation (ES‐MDA), SLM‐SLP effectively and efficiently mitigates the ensemble collapse problem in the course of uncertain quantification.
Humans Colonized Polynesia Much Earlier Than Previously Thought
Authors: Sima Richard
Published: May 2020

Evidence from mud, charcoal, and feces suggests humans arrived in East Polynesia during the driest period in 2 millennia.
No Mask? You May Not Worry About Climate Change, Either
Authors: Duncombe Jenessa
Published: May 2020

People untroubled by climate change are more likely to forgo masks in public.
Feasibility of Near‐Real‐Time GOLD Data Products
Authors: Codrescu S. M. , Rowland W. F. , Plummer T. M. , Vanier B. A. , Berger T. E. , Codrescu M. V.
Published: May 2020

A primary limitation for accurate specification and forecasting of the thermosphere‐ionosphere (TI) system is uncertainty in the system forcing. This significantly impacts users who have operational and real‐time interests in the current and future state of the TI system. Since Global‐Scale Observations of the Limb and Disk (GOLD) observations are expected to provide information about both the current state and forcing of the TI system, GOLD products could be an operational asset if they could be provided in near real time. Production of GOLD data products requires knowledge of the satellite pointing and location. The current scientific processing implementation contains an operationally significant delay to await definitive location and as‐flown pointing. We present the results of a demonstration low‐latency processing system that assumes the nominal satellite position and pointing to produce low‐latency GOLD data products. The resulting products are reasonably similar to the scientific version but are available within minutes rather than hours.
Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome
Authors: Willerslev-Olsen Andreas , Buus Terkild B. , Nastasi Claudia , Blümel Edda , Gluud Maria , Bonefeld Charlotte M. , Geisler Carsten , Lindahl Lise M. , Vermeer Maarten , Wasik Mariusz A. , Iversen Lars , Becker Jürgen C. , Andersen Mads Hald , Gjerdrum Lise M. R. , Litvinov Ivan V. , Litman Thomas , Krejsgaard Thorbjørn , Woetmann Anders , Ødum Niels
Published: May 2020

Sézary syndrome (SS) is a heterogeneous leukemic subtype of cutaneous T-cell lymphoma (CTCL) with generalized erythroderma, lymphadenopathy, and a poor prognosis. Advanced disease is invariably associated with severe immune dysregulation and the majority of patients die from infectious complications caused by microorganisms such as,Staphylococcus aureus, rather than from the lymphoma per se. Here, we examined if staphylococcal enterotoxins (SE) may shape the phenotype of malignant SS cells, including expression of the regulatory T-cell-associated marker FOXP3. Our studies with primary and cultured malignant cells show that SE induce expression of FOXP3 in malignant cells when exposed to nonmalignant cells. Mutations in the MHC class II binding domain of SE-A (SEA) largely block the effect indicating that the response relies at least in part on the MHC class II-mediated antigen presentation. Transwell experiments show that the effect is induced by soluble factors, partly blocked by anti-IL-2 antibody, and depends on STAT5 activation in malignant cells. Collectively, these findings show that SE stimulate nonmalignant cells to induce FOXP3 expression in malignant cells. Thus, differences in exposure to environmental factors, such as bacterial toxins may explain the heterogeneous FOXP3 expression in malignant cells in SS.
MYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma
Authors: Wei Sung-Jen , Nguyen Thinh H. , Yang In-Hyoung , Mook Dustin G. , Makena Monish Ram , Verlekar Dattesh , Hindle Ashly , Martinez Gloria M. , Yang Shengping , Shimada Hiroyuki , Reynolds C. Patrick , Kang Min H.
Published: May 2020

Despite the improvement in clinical outcome with 13-cis-retinoic acid (13-cisRA) + anti-GD2 antibody + cytokine immunotherapy given in first response ~40% of high-risk neuroblastoma patients die of recurrent disease. MYCN genomic amplification is a biomarker of aggressive tumors in the childhood cancer neuroblastoma. MYCN expression is downregulated by 13-cisRA, a differentiating agent that is a component of neuroblastoma therapy. Although MYC amplification is rare in neuroblastoma at diagnosis, we report transcriptional activation of MYC medicated by the transcription factor OCT4, functionally replacing MYCN in 13-cisRA-resistant progressive disease neuroblastoma in large panels of patient-derived cell lines and xenograft models. We identified novel OCT4-binding sites in the MYC promoter/enhancer region that regulated MYC expression via phosphorylation by MAPKAPK2 (MK2). OCT4 phosphorylation at the S111 residue by MK2 was upstream of MYC transcriptional activation. Expression of OCT4, MK2, and c-MYC was higher in progressive disease relative to pre-therapy neuroblastomas and was associated with inferior patient survival. OCT4 or MK2 knockdown decreased c-MYC expression and restored the sensitivity to 13-cisRA. In conclusion, we demonstrated that high c-MYC expression independent of genomic amplification is associated with disease progression in neuroblastoma. MK2-mediated OCT4 transcriptional activation is a novel mechanism for activating the MYC oncogene in progressive disease neuroblastoma that provides a therapeutic target.
A circular RNA derived from DAB1 promotes cell proliferation and osteogenic differentiation of BMSCs via RBPJ/DAB1 axis
Authors: Chia Weekai , Liu Jiali , Huang Yi-Gang , Zhang Changqing
Published: May 2020

Osteogenesis (OS) is a type of differentiation that is of great importance for bone homeostasis. Increasing studies suggest circular RNAs (circRNAs) as pivotal regulators in OS. This study proposed to investigate mechanism mediated by circRNAs in OS. Based on GEO data and qRT-PCR assay, we found that circ-DAB1 (has_circ_0113689) was significantly up-regulated during osteogenic differentiation in human BMSCs. Overexpressing circ-DAB1 proliferation and osteogenic differentiation of BMSCs, whereas silencing circ-DAB1 elicited opposite functions. Subsequently, recombination signal-binding protein for immunoglobulin kappa J region (RBPJ), an important transcription factor in NOTCH pathway, was found to interact with DAB1 promoter while not to combine with circ-DAB1. Interestingly, circ-DAB1 overexpression could result in the increasing binding between RBPJ and DAB adaptor protein 1 (DAB1) promoter. Overexpressing circ-DAB1 upregulated RBPJ in BMSCs to induce DAB1 level. Further, we uncovered that circ-DAB1 upregulated RBPJ through sequestering miR-1270 and miR-944. Restoration experiments demonstrated that knocking down either RBPJ or DAB1 partially recovered BMSC proliferation and osteogenic differentiation that was suppressed by circ-DAB1 overexpression. Conclusively, circ-DAB1 promotes cell proliferation and osteogenic differentiation of BMSCs via NOTCH/RBPJ pathway.
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo
Authors: Sanna Simona , Esposito Sonia , Masala Alessandra , Sini Paola , Nieddu Gabriele , Galioto Manuela , Fais Milena , Iaccarino Ciro , Cestra Gianluca , Crosio Claudia
Published: May 2020

TDP-43 pathology is a disease hallmark that characterizes both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). TDP-43 undergoes several posttranslational modifications that can change its biological activities and its aggregative propensity, which is a common hallmark of different neurodegenerative conditions. New evidence is provided by the current study pointing at TDP-43 acetylation in ALS cellular models. Using both in vitro and in vivo approaches, we demonstrate that TDP-43 interacts with histone deacetylase 1 (HDAC1) via RRM1 and RRM2 domains, that are known to contain the two major TDP-43 acetylation sites, K142 and K192. Moreover, we show that TDP-43 is a direct transcriptional activator of CHOP promoter and this activity is regulated by acetylation. Finally and most importantly, we observe both in cell culture and in Drosophila that a HDCA1 reduced level (genomic inactivation or siRNA) or treatment with pan-HDAC inhibitors exert a protective role against WT or pathological mutant TDP-43 toxicity, suggesting TDP-43 acetylation as a new potential therapeutic target. HDAC inhibition efficacy in neurodegeneration has long been debated, but future investigations are warranted in this area. Selection of more specific HDAC inhibitors is still a promising option for neuronal protection especially as HDAC1 appears as a downstream target of both TDP- 43 and FUS, another ALS-related gene.