bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytological and Histopathological Characteristics of Canine Transmissible Venereal Tumour in Male and Female Dogs Before and After Vincristine Treatment
Authors: Katjimune J.T. , Mathew C.
Published: September 2021

Canine transmissible venereal tumour (CTVT) is a neoplasia naturally transmitted in susceptible dogs through coitus. CTVT has a worldwide distribution, with a high prevalence in tropical and sub-tropical urban environments. The study aimed at evaluating CTVT lesions in local breeds of dogs and to assess morphological changes based on sex before and after administration of vincristine sulphate. Clinical and gross morphology, fine needle aspirates cytology (FNAC) and routine histopathology methods were used. Two FNAC and histopathological microscopic slide sections from each of the seven sampled dogs were stained with Giemsa stain and Hematoxylin and Eosin. All dogs were treated with vincristine once weekly over a six weeks period after which clinical morphological and histopathological changes were assessed. Grossly, before treatment the tumour masses appeared irregular, cauliflower like with tendency to bleed, sizes ranged from ≥5cm to ≤2cm with or without metastasis to regional lymph nodes. Cytologically, the tumours had homogenous, sheet-like cellular mass. Cytoplasm with punctate vacuoles, anisokaryosis with anisonucleoliosis and coarse to reticulate nuclear chromatin were seen. Lymphocytoid cell pattern was dominant cell type. Histopathology showed sheets of round cells with nuclear and cytoplasmic variations. Histopathology of the treated dog revealed hyper-cellularity, absence of nucleoli, prominent mitotic figures, reduced cell size and presence of inflammatory cells. There was no difference on the cellular changes after vincristine treatment between female and male dogs. Cytology and histopathology showed that vincristine sulphate suppresses the development of tumour through alteration of cellular morphology with no difference between male and female dogs.
The Effect of Oil Contamination on some Geotechnical Properties of West Qurna Oilfield Soils at Basrah, Southern Iraq
Authors: Al-Nimah Ahmed K.
Published: September 2021

Oil contamination in soils causes several geotechnical problems that must be considered during construction. The contamination occurs due to oil seepage which could happen during oil explorations and production processes or oil transportation. The site of West Qurna oilfield in Basrah was selected for this study because it has witnessed oil seepages many times. In order to study the significant impact on geotechnical properties of soils in the West Qurna site, as uncontaminated bulk soil sample was taken at a depth of 1 m, and crude oil was added at weight ratios of 2, 4, 6, 8, and 10 %. Laboratory tests were performed on all samples; these tests included particle size distribution, moisture content, Atterberg’s limits, consolidation, unconfined compressive strength, and water absorption. The results show that soil at the West Qurna site is clayey silt with little sand and the moisture content is 29.21%. The values of liquid limit and plasticity index were gradually decreased, while the plastic limit was increased with increasing of crude oil in the soil of study. There was an increase in consolidation coefficients [compressive index, swelling index, pre-consolidation pressure, and coefficient of consolidation] with an increase in the percentages of crude oil in the soil. The results also show that there was a decrease in the values of unconfined compressive strength and absorption of water as the crude oil was increased in the soil.
Water Phase Inclination Theory for Hydraulic Conductivity Determination of Vadose Zones in Shallow Water Table Systems
Authors: Ali Arkan Radi
Published: September 2021

Water Phase Inclination is an innovative theory for hydraulic conductivity and determination of vadose zone overlying shallow water table systems. It was originated and analytically derived from Darcy's Law and based on some physio-mechanical properties of soil. Al-Musayab area of 176 Km2 at Mesopotamian region, mid-Iraq was undertaken as a case study. It consists of unconsolidated quaternary deposits and is usually finer-grained than the underlying pebbly sandstone with Mediterranean weather. The Experimental part was divided into field tests which include double ring infiltrometer tests, water table depth measurements and sampling of 32 undisturbed soil samples of surface layers scattered over the study area Whereas lab tests include; the falling and constant head permeability, grain size distribution (sieve and hydrometer analysis), soil specific gravity, direct shear tests and the measuring of Water Phase Inclinations. Angle \emptyset a glassy infiltration box is an experimental device that was manufactured to measure the Water Phase Inclination angle and aquifer simulation. It is found a generalized linear relationship between  and the angle of internal friction which is valid for   23.37 with correlation factor R² = 0.99 and both angles depend on soil texture. The k values estimated by WPI theory and that measured by traditional techniques offer a linear relationship with acceptable Root Mean Square Error equals 0.0642 < 0.1 the max allowable limit and correlation factor R² = 0.96, pointing out to the reliability and stability of the Water Phase Inclination results.
Effect of Discharge on Water Quality in Euphrates River Between Hit and Ramadi, Iraq
Authors: Abdulrahman May F.
Published: September 2021

The objective of this study was to determine the relationship between water drainage rates in Hit and Ramadi cities and the water quality of the Euphrates River. The studied area of Euphrates River extends from Hit to Ramadi, where two sampling stations were selected monthly in 2012, 2013, and 2018. The results indicate variations and decreasing in the monthly discharge rate of the study period; the year 2012 had higher discharge rate values than 2013, which in turn was higher than in 2018, for both gauging stations. Our results indicate that with decreasing discharge trends, some selected water quality parameters had an increasing trend. During the selected years, there was an increase in levels of sulfate, nitrate, dissolved oxygen, magnesium, and turbidity in the Ramadi station compared to the Hit station, as the rate of discharge of the river increases in the former. A positive significant correlation between discharge rate and dissolved oxygen and dissolved solids were reported. The Haditha Dam and its reservoir affect the downstream discharge rate and in turn the water quality at Hit and Ramadi Cities.
Church Pew Exercise Integrated With Conventional Physical Therapy Following Total Knee Arthroplasty (TKA): Case Report
Authors: Gonzales Randell , Danoff Jerome
Published: September 2021

Background and Purpose: Physical therapy treatment following Total knee Arthroplasty (TKA) consists of a combination of strengthening and range of motion exercises. The exercise technique, church pew exercise (CPE), has been proposed to enhance quadriceps facilitation and improve function. This is a technique that has the patient standing and rocking forward/back. The backward motion is arrested by engagement of the upper calf against a solid object, creating a sudden flexion torque at the knee and a sudden extension torque at the hip. The combination of CPE with standard physical therapy is claimed to provide better quadriceps control and faster walking post TKA. In this case study, a 51-year-old female with decreased knee active and passive range of motion (ROM), decreased lower extremity (LE) muscle strength, and limited ambulation post left knee TKA, received conventional physical therapy treatment plus CPE. Methods: The patient received 11 physical therapy home sessions. The first 8 sessions were used to strengthen her knee and increase active and passive ROM. The CPE intervention was performed 3 weeks post-surgery, during the last 3 physical therapy sessions. At these three sessions the patient performed the Timed Up and Go (TUG) before and after CPE. Outcomes: At initial evaluation, 4 days post left knee TKA, this patient’s left knee active ROM was only 15 to 76 degrees, and manual muscle testing at her hip and knee indicated strengths of 2- (hip flexors), 3- (hamstrings and quadriceps), and 3+ (hip abductors), all out of 5, and her times on two trials of the TUG were 30.31 and 30.65 sec, indicating impaired functional ability. At all CPE sessions (3 weeks post-surgery) the patient demonstrated increased gait speeds (i.e. shorter times) on the TUG after the CPE (pre CPE mean = 13.2 sec; post CPE mean = 11.2), increased stance time on her affected lower extremity, and increased step length on her contra-lateral lower extremity. The patient reported increased knee stability. Clinical Relevance: Rationale for CPE is based on neurological facilitation of quadriceps and other lower extremity muscles. However, to engage in this exercise the patient must have the ability to balance and to control the hip and knee joints. This patient required several weeks of strengthening and active and passive ROM exercises before she could perform the CPE. Once able to perform the CPE, she demonstrated improvements in her walking ability, and she expressed greater confidence. Conclusion: Provided a minimal level of strength and active and passive ROM has been attained, CPE may be a valuable short-term supplement to current strengthening regimens addressing quadriceps functional deficits following TKA. Other conditions that involve gait problems related to quadriceps insufficiency might also benefit. The long-term efficacy of CPE remains to be determined.
Workplace Access to Journals: Is it Sufficient to Support Quality Healthcare Practice in Medical Imaging Workers?
Authors: Shanahan Madeleine
Published: September 2021

Introduction: Journals are important tools for disseminating new knowledge to health professionals. The purpose of this study was to investigate workplace access to journals. Medical imaging workers (MIWs) were the allied health professional group studied. Methods: A two phase sequential exploratory mixed methods design was adopted to collect data from MIWs to develop a list of professionally relevant journals and to examine accessibility of journals across the profession. In addition, the derived list of journals was further examined to determine open access and open article availability. Results: Twenty-seven percent (n=88) of survey respondents (N=362) reported that they have access to one (18%, n=58) or none (9%, n=30) of the 94 identified professionally relevant journals. Difference in access was statistically significant for work setting (university, clinical), health sector (public, private), workplace type (teaching, non-teaching hospital, clinic), and area of specialization (nuclear medicine, radiation therapy, radiography, sonography). A positive relationship was shown to exist between increased effective workplace access to journals and frequency of use. This study also identified that open access journals and articles are currently limited for Medical Imaging workers. Conclusion: Whilst journals provide access to current peer-reviewed evidence, this study established that workplace access is currently problematic for medical imaging workers. Workplaces must act to increase access to journals for Medical Imaging Workers so that these professionals can harness new knowledge and base their practice on current peer–reviewed evidence.
Assessing Self-Reported Interprofessional Competency in Health-Care Education: Impact of New Curriculum
Authors: Goreczny Anthony , Bednarek Melissa , Hawkins Susan , Hertweck Mark , Schreiber Jodi , Sterrett Susan
Published: September 2021

Purpose: The Interprofessional Education Collaborative Expert Panel (IPEC) has identified four competencies essential for interprofessional functioning in the health professions. Those four competencies are (a) values/ethics for interprofessional practice, (b) roles/responsibilities, (c) interprofessional communication, and (d) teams and teamwork. Design of effective curricula to develop competence in these skills will improve interprofessional functioning in healthcare. The purpose of this study at a small northeastern university was to examine impact of a small group interprofessional education (IPE) curriculum on student awareness of one of the competencies, understanding roles and responsibilities. Methods: The quantitative study data consisted of student completion of a 13-item self-report questionnaire based on the four competencies of IPE after participating in two interprofessional events in the same semester (one large group introductory event and one small group case event). Students were enrolled in professional educational programs, including counseling psychology, nursing, occupational therapy, physical therapy, and physician assistant. Students were divided into groups of 8-10 students from participating academic programs forming interprofessional groups. They completed a 13-item self-report questionnaire based on the four competencies after each of the two events. Results: Results of Multivariate Analysis of Variance (MANOVA) revealed a significant difference between the first and second events, multivariate F (13, 476) = 24.61, p = .000. Results of univariate ANOVAs revealed significant differences for each variable, with scores from the case study session higher on each item than scores for the opening event. Factor analysis of data from the opening event yielded a single factor, which accounted for 63.4% of the variance in the scale. Factor analysis of data from the small group case event also yielded a single factor accounting for 65.9% of scale variance. Cronbach’s alpha revealed a very high internal consistency of .951 and.952, for the two events respectively. Conclusions: IPE events can positively increase self-report measures of IPE competencies. The assessment tool used may have measured one overarching construct of collaboration. The tool represents an initial effort toward measurement of each of the four specific competencies, an area in need of refinement. This study demonstrated impact of IPE events housed within an IPE curriculum.
The Effects of Plyometric Training on Spinal and Supraspinal Motor Control
Authors: Doeringer Jeffrey
Published: September 2021

Purpose: The purpose of this study was to determine the effects of plyometric training on spinal and supraspinal motor control in healthy active females. Methods: A 2 (Group) x 2 (Session) x 2 (Stance) mixed model design was used for homosynaptic depression (HD) and recurrent inhibition (RI) data. A 2 (Group) x 2 (Session) mixed model design was used for H:M ratios and V-waves (V:M ratios) data. Thirty-one participants were recruited to participate in the study. Participants participated in either the training or control group for 6-weeks. All participants were measured pre- and post-intervention on H:M ratios, HD, RI, and V-waves. Results: There were no statistically significant interactions for any of the dependent variables (p > 0.05). There was a session main effect for RI (p = 0.01) as well as a group main effect (p = 0.01) and a stance main effect (p < 0.01) for HD. Conclusions: Performing plyometric training does not modulate the spinal or supraspinal motor control based on the findings of this study. Plyometric training is not the only component that should be used in Anterior Cruciate Ligament Injury Prevention Programs to alter motor control. A more challenging and higher impact plyometric exercises are suggested to allow more demand on the neural drive of the physically active participants.
An investigation of screening for medical referral by Physical Therapists
Authors: Mount Heather , Graham Cecilia , Clark Diane , Morris David , Foley Kathleen
Published: September 2021

Screening for medical referral is essential to physical therapist practice; however, no studies have examined medical screening across physical therapy practice settings. The purpose of this study was to determine if physical therapists in a variety of practice settings, given brief clinical vignettes, would screen for medical referral in a similar manner. The Delphi Technique was implemented to establish content validity, although only 2 vignettes reached 100% consensus by the expert panel. After reviewing the vignettes, physical therapist subjects determined if they would provide intervention, provide intervention and refer, or refer before intervention. To determine which variables were associated with identified appropriate decisions in each category, 4 sets of logistic regressions were performed. A random sample of APTA members in targeted sections (n=214) completed the survey. Physical therapists with more than 23 years experience were 7 times more likely to make similar management decisions in noncritical vignettes then those with 11 years or less. Half of the participants practiced in outpatient practice settings. In critical medical vignettes, 86% of physical therapists made similar decisions. Physical therapists in this study made identified appropriate management decisions for 90% of the vignettes. Board certification, practice setting and highest earned degree were not found to be statistically significant. It is imperative not only to ensure that the client is appropriate for physical therapy intervention, but it is also vital to recognize and identify signs and symptoms that warrant evaluation by other health care providers.
Knowledge and behavioral patterns of youth ice hockey parents regarding sport concussion: a pilot study
Authors: Konin Jeff , Horsley Delaney
Published: September 2021

Purpose: There is an abundance of available concussion education programs for parents of youth ice hockey players. Parents play a vital role in recognizing signs and symptoms of a concussion sustained by a child, and therefore their knowledge and retention of such information is deemed to be very important. The purpose of the pilot survey is identify the general knowledge parents of youth ice hockey players possess regarding concussion. Methods: A survey of a sample of convenience was utilized. Forty-five parents (40 to 49 years of age) of youth ice hockey players were asked to complete a one-page survey to assess their knowledge of concussion. The ages of their children ranged from seven through ten, and all parents were recruited to participate while attending a team practice session at a local ice hockey arena. Results: Parents generally were aware of common concussion related symptoms (headache 98%, difficulty with concentrating 96%, mental confusion 91%, vomiting 91%, sensitivity to light 91%, and blurred vision 82%) while not so familiar with symptoms such as tinnitus (62%) and agitated behaviors (47%). Fifty percent of those surveyed were unaware if their youth hockey organization had a concussion policy. Conclusion: Parents of youth ice hockey players seem to fail to retain information learned from concussion education programs. Barriers to learning retention may include the ages of the youth participating, the abundance of informal and inconsistent information that is available, and the lack of organizational administration of concussion education programs. Parents appear to be receptive to receiving more information regarding the safety of their children. Parental recognition of the signs and symptoms of a concussion sustained while playing youth ice hockey may lead to more appropriate and timely management of the injury.
reputación corporativa y el uso de las Tecnologías en la Era Digital del Siglo XXI ¿influyen en la reputación corporativa y la permanencia de las empresas?
Authors: Ruíz Contreras Angélica Belén
Published: September 2021

En esta investigación se presenta el análisis de resultados de los factores que influyen en la falta de continuidad de las empresas y si la variable tecnología es pieza clave en la actividad o inactividad de estas. Se analizó una muestra de 832 empresas de diversos sectores en los Municipios de Ajalpan, Altepexi, Tehuacán y Santiago Miahuatlán, Puebla y se encontró que aun en esta Era Digital del Siglo XXI, la variable Tecnología no tiene una influencia significativa para la reputación corporativa y su permanencia en el mercado. Los factores con mayor impacto son los externos y la variable economía del país la más significativa. “El siguiente documento es parte de una investigación desarrollada por Relayn” (Peña,N.B., Aguilar, O.C. & Posada, R, 2017).
Abstract
This research presents the analysis of the results of the factors that influence the lack of continuity of the companies and whether the variable technology is a key element in the activity or inactivity of the same. A sample of 832 companies from different sectors in the municipalities of Ajalpan, Altepexi, Tehuacán and Santiago Miahutlán, Puebla was analyzed and it was found that even in this Digital Age of the XXI Century, the variable Technology does not have a significant influence for the corporate reputation and his stay in the market. The factors with the greatest impact are the external factors and the variable economy of the country the most significant. "The following document is part of an investigation developed by Relayn" (Peña, N.B., Aguilar, O.C. & Posada, R, 2017)
impacto de factores externos en la estructura organizacional de las mypes en Nogales, Sonora Luján Gil
Authors: Luján Gil Juan Manuel , Perea Camacho Ana Luisa , González López Adrián , Chiquete Bermúdez Rosa Isela
Published: September 2021

El artículo muestra las correlaciones existentes entre la influencia percibida de los factores externos sobre la estructura organizacional de las Mype’s del municipio de Nogales, Sonora. Su fundamentación se da a partir de la importancia del análisis de factores externos para la planeación estratégica de una empresa. Se encontró que, en Nogales, Sonora existe una correlación de 0.095 ** entre la percepción de influencia de los factores externos y la estructura organizacional. El artículo aborda a detalle las correlaciones existentes y establece la implementación del Perfil de Oportunidades y Amenazas para medir su impacto.

Abstract

The article shows the correlations between the perceived influence of external factors on the organizational structure of Mype's in the municipality of Nogales, Sonora. Its foundation is based on the importance of analyzing external factors for the strategic planning of a company. It was found that, in Nogales, Sonora there is a correlation of 0.095 ** between the perception of influence of external factors and the organizational structure. The article deals in detail with the existing correlations and establishes the implementation of the Opportunities and Threats Profile to measure its impact.
análisis de las actividades de mercadotecnia como factor de permanencia de las mypes en Paraíso, Tabasco
Authors: De la Cruz Alcudia Abi Roxana , Ligonio Hernández Nínive , Valenzuela Córdova Florelis , de la  Cruz González Flor
Published: September 2021

El objetivo de este artículo es generar información que sirva como punto de partida para identificar áreas de oportunidad y de mejora en las Mypes del municipio de Paraíso, Tabasco con la finalidad de incrementar la competitividad y lograr la permanencia de las mismas. Para ello, se hizo un análisis de los resultados de las principales actividades de mercadotecnia que se efectúan en las Mypes del municipio y se determinó el impacto de dichas actividades en su permanencia y crecimiento en el mercado. El estudio se realizó a partir del método cuantitativo con un alcance descriptivo, donde se identifican a las empresas que dentro de sus procesos promueven esfuerzos e implementan acciones en materia de mercadotecnia elevando su competitividad.
Abstract 
The objective of this article is to generate information that serves as a starting point to identify areas of opportunity and improvement in the Mypes of the municipality of Paraíso, Tabasco in order to increase competitiveness and achieve their permanence. To do this, an analysis was made of the results of the main marketing activities that take place in the Mypes of the municipality and the impact of these activities on their permanence and growth in the market was determined. The study was carried out using the quantitative method with a descriptive scope, where companies that promote their efforts and implement actions in marketing matters are identified, increasing their competitiveness.
conocimiento, métodos e innovación empresaria
Authors: Cárdenas Jairo Alberto , Cristancho José Alberto , Sayago Ortiz Nhora Esperanza , Flórez Leal Martha Rocío
Published: September 2021

La innovación crea organizaciones de valor, que se apalancan desde su gestión del conocimiento, permitiéndose entender “que sabemos”, lo cual determina un proceso de cultura organizacional de creación de valor del negocio donde la innovación y los procesos metodológicos para innovar constituyen la base del apalancamiento del nivel de desarrollo del producto, modelo del negocio de la empresa, gestión y liderazgo de los equipos de trabajo y las relaciones con los clientes.
Abstract
nnovation creates value organizations, which are leveraged from their knowledge management, allowing them to understand "what we know", which determines a process of organizational culture to create business value where innovation and methodological processes to innovate form the basis of the leverage of the level of product development, business model of the company, management and leadership of work teams and customer relations.
impacto del perfil académico de los directivos en la gestión del talento humano en las mypes
Authors: Cruz Estudillo Erika , Pérez Barroso Gustavo , Torres Gómez Maribel , Luna Santiago Néstor Jehová
Published: September 2021

El artículo muestra los resultados de la investigación realizada a los directivos de las micro y pequeñas empresas (mypes) del municipio de Oaxaca de Juárez. El objetivo es analizar la relación del grado de estudios deldirector con la gestión del recurso humano (RH). El método utilizado en la es de tipo cuantitativo con alcance correlacional. Se analizaron 5 items relacionados con el perfil demográfico del director y 9 ítems relacionados con la gestión detalento humano, todos con una escala de respuesta tipo Likert de 5 puntos. Se identificó que no existe una relación en las variables analizadas, pero existe una tendencia que a mayor grado de estudios menor impacto en la gestión de R.H.
AbstractThe article shows the results of the research carried out by the directors of the Micro and small Enterprises (mypes) of the municipality of Oaxaca de Juárez. The objective is to analyse the relationship of the Director's degree of studies with the management of the Human Resource (RH). The method used in the quantitative type is with correlational scope. We analyzed 5 items related to the demographic profile of the Director and 9 items related to the management of human talent, all with a Likert type response scale of 5 points. It Was identified that there is no relationship in the variables analyzed, but there is a trend that a higher degree of studies less impact on the management of R.H.
diagnóstico de competitividad del sector de mezcal de Durango, México
Authors: Arreola Gurrola Sergio , Saldaña Durán Claudia Estela
Published: September 2021

El objetivo del presente trabajo fue desarrollar un diagnóstico de la competitividad del clúster de mezcal de Durango. Se utilizó un diseño concurrente de métodos mixtos, en el enfoque cualitativo se usó un diseño fenomenológico y en el cuantitativo un cuestionario adaptado. Resultando que cuatro fuerzas competitivas (la amenaza de nuevos competidores, amenaza de productos sustitos, poder negociador de los compradores y la rivalidad de la industria) erosionan el valor que pueden generar las empresas en el sector de mezcal en Durango, así mismo se hallaron tres grupos estratégicos que difieren en sus indicadores de competitividad.
Abstract
The objective of this work was to develop a diagnosis of the competitiveness of theDurango mezcal cluster. A concurrent design of mixed methods was used, thequalitative approach used a phenomenological design and in quantitative an adaptedquestionnaire. It turns out that four competitive forces (the threat of new competitors,threat of substitute products, buyer trading power and industry rivalry) erode the valuethat companies can generate in the mezcal sector in Durango, as well as threestrategic groups that differ in their competitiveness indicators.
Screening for Inverdale (FecXI) Mutation in BMP15 Gene in Prolific Turkish Awassi Sheep
Authors: GEDİK Yasemin
Published: September 2021

In the early 1980s, by the determination of the Boorola gene (FecB) in Booroola sheep with high ovulation rate, there has been a great interest for identification of genes that are responsible for prolificacy and their use in breeding programs. The mutation occurred in Bone morphogenetic protein 15 (BMP15), Bone morphogenetic protein-1B (BMPR-1B) and Growth differentiation factor 9 (GDF9) genes have been found to increase the ovulation rate. Additionally some others gene are known to exist based on expressed inheritance patterns although the location of mutations has yet to be found. In the BMP15 gene, with almost the same phenotypic expression eight distinct mutations have been recognized, among them Hanna (FecXH) and Inverdale (FecXI) were identified first in Romney sheep in New Zealand. X-linked dominant genes with sterility in homozygous females are the modes of inheritance of the BMP15 gene. A total of 88 prolific Awassi sheep were screened for the presence of the FecXI mutation in the BMP15 gene and FecXI mutation was not found in any of the sheep tested.
A Review on – Estimation of Residual Solvents by Different Analytical Method
Authors: Umamaheswari D. , T Neha Gupta , Kumar M. , Venkateswarlu B.S.
Published: September 2021

Residual solvents are the unwanted substances (solvents) used or created throughout the manufacture of a excipients, drug or
pharmaceutical formulation and don't seem to be utterly removed by sensible ways within the final finished product. These solvents
may be harmful in nature. Therefore, analysis of residual solvents becomes a necessary tool for the standard management of
prescribed drugs. The appropriate limits for these substances are given in ICH. Solvents are widely used during the manufacturing,
purification and processing of pharmaceutical substances. The residues of these solvents must be removed to the extent possible, as they do not have any therapeutic effect but can cause undesirable effects in the consumers. These solvent residues concentrationshould not exceed the limits prescribed in the ICH guidelines. This present review work is emphasized on various techniques (Loss on drying, Thermogravimetric analysis, Near- IR spectroscopy).
Formulation and Evaluation of Fluvastatin Loaded Solid Lipid Nanoparticles
Authors: Sundari DR. P. Tripura , G. Akhila
Published: September 2021

In the present work Fluvastatin was taken which is anti-hyper lipidemic drug used for chronic treatment. It belongs to BCS class-II
which means low soluble & high permeable drug. The current dosage regimen is 20-80mg for 2-3 times a day. The present work aims at reducing the dose of the drug by converting it into nanocarrier systems. For this purpose, SLN’s were prepared by employing Compritol as lipid, Soyalecithin as lipophilic surfactant, Tween-80/PEG-400 as hydrophilic surfactant systems. The prepared formulations were named as T1 to T4 with Tween-80 and P1 to P4 with PEG-400. All the prepared formulations are evaluated for drug content, entrapment efficiency and drug release studies. Among all the preparations best formulation was found to be P3 in terms of Drug content of 96.2%, Entrapment efficiency of 90.87% , Drug release of 61.0%, Particle size of 578nm with Zeta potential of -26mV. The present study conclusively demonstrated that the solubility of drug was improved by entrapment of drug into solid lipid carrier which led to prolongation of drug release.
Orodispersible Tablets: A New Trend in Drug Delivery
Authors: Singh Harkirat , Kaur Lakhvir , Singh Gurjeet , Dhawan RK
Published: September 2021

The oral route is the most popular and favoured method of drug administration. Orodispersible tablets are becoming more common
among novel oral drug delivery systems because they increase patient compliance and provide some additional benefits over other
oral formulations. They are also strong unit dosage types that, in the presence of saliva, disintegrate in the mouth within a minute
due to super disintegrants in the formulation. As a result, this method of drug delivery aids in proper peroral administration of
paediatric and geriatric patients who have difficulty swallowing. Various scientists have used various methods to create orodispersible tablets. The compression process is, however, the most popular method of preparation. Molding, melt granulation, phase-transition technique, sublimation, freeze-drying, spray-drying, and the effervescent method are some of the other unique processes. The flavour of these tablets is significant since they dissolve immediately in the mouth. To mask the drug's acidic flavour, a variety of techniques have been used. In this area, a number of scientists have looked at a variety of drugs. They are tested in the fields of stiffness, friability, wetting time, moisture absorption, disintegration test, and dissolution test, much as any other solid dosage types.
A Review on Six Membered Nitrogen Containing Heterocyclic Compounds with Various Biological Activities
Authors: Sanu Meenu C , Joseph Jincy , Chacko Divya
Published: September 2021

The heterocycles are currently considered as promising compounds for the development of novel therapeutic agents. The analogs of
nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More
than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the
forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based
heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and
promising applications in medicinal chemistry is ever-growing. This paper aims to review on the pharmacological activities of six
membered nitrogen contains heterocyclic compounds.
Formulation and Evaluation of Transdermal Patch of Blonanserin
Authors: Patel Dhaval J. , Patel Saurav M. , Rathi Sanjesh G. , Shah Shrenik K.
Published: September 2021

The objective of the present study was to formulate and evaluate transdermal patch of Blonanserin. Blonanserin transdermal patches
were prepared by solvent casting method using natural and synthetic polymer. Various plastisizer were screened along with polymers. Drug excipient compatibility studies concluded that the drug and excipient are compatible with each other. The prepared patches were evaluated for physico-chemical parameters to justify their suitability for transdermal use. Formulations containing Xanthan Gum with plasticizer propylene glycol gives best drug release in 8 hours. More than 90% drug release found after 8 hours in formulation F5. Hence F5 formulation is considered as optimized batch. F5 batch was found stable during stability study. Blonanserin transdermal patches were successfully prepared by solvent casting method using Xanthan Gum natural polymer.
Antioxidant Activity and In-vitro Cytotoxicity Study of Novel Dombeya wallichii (An invasive plant) against Human Lung Cancer Cell Line
Authors: Kumar U Deepak , L Nivetha , Nisha P Devipriya
Published: September 2021

Recent research is focusing on the search for new types of natural chemotherapeutic agents derived from plants which are proving
to be excellent sources of new compounds. The present research article was aimed to study the antioxidant activity of ethanolic
extracts of Dombeya wallichii, which is an invasive plant (Plants that do not occur naturally in a region but proliferate in the area they have been introduced into) by DPPH radical scavenging method which exhibited antioxidant activity with IC50 value of 744.04 µg /ml. The cytotoxic activity of ethanolic extracts from the leaves of Dombeya wallichii, by in-vitro cytotoxic assays like MTT against lung adenocarcinoma epithelial cell line A549 which exhibited anticancer activity with IC50 value of 2.50 µg /ml concentration. This study creates the awareness about this plant which is having potential antioxidant activity, cytotoxic activity and the outcomes propose that D. wallichii as a potential source of alternative medication drugs for treating cancer. Further research is required to find out the effective mechanisms responsible for anticancer properties and for curating the therapeutic benefits of the less explored and exploited invasive species.
A Study on Physical and Physiological Impact of Polycystic Ovary Syndrome
Authors: B.P Sathish Kumar , Ghosh Dr. Sayantan , Das Dr. Lipika , Jose Dr. Aksa Merin
Published: September 2021

Polycystic ovary syndrome is a relatively common hormonal disorder that causes a number of different symptoms in women of
reproductive age. In such conditions, enlarged ovaries containing multiple small cysts (polycystic ovaries), are found. Although most
women with PCOS have polycystic ovaries, some affected women do not. Common to all women with PCOS is an irregularity in
menstrual cycle and the presence of excess male hormones (androgen). It disrupts the functioning of the reproductive organs that produce progesterone and estrogen, the hormones that regulate the menstrual cycle. A prospective observational study was carried out in 125 inpatients, after taking written informed consent from patients those who met the study criteria. A total of 125 patients were enrolled in the study, it was observed that 17.74% have experienced moderate depression, 18.54% patients experienced major irregular menstrual period problem, 2-25% of the patients were dealing with body weight, and 6.45% patients were identified that the growth of visible hair on the upper lip as a major problem. It was also found that 8.87% of patients experienced major menstrual cramps and patients were found worried about PCOS and hence disturbing their quality of life. Various long-term complication and co morbidities have been associated with PCOS and early diagnosed and therapeutic interventions are needed. PCOS is a chronic disease with manifestations across the life span and represents a major health and economic burden. Management should focus on support, education, addressing physiological factors and strongly emphasizing healthy lifestyle with targeted medical therapy as required. Addressing hyperandrogenism is clinically important and monitoring for and managing longer-term metabolic complications including dyslipidemia, IGT, DM2, cardiovascular risk factors, is crucial. Overall, further research is needed in this complex condition.
Pensar juntos: intelectuales, perspectivas y prospectivas de la crisis del 2020
Authors: Fernández Anna María
Published: September 2021

En todas las sociedades, los intelectuales —y la gente en general— tienen ideas sobre el pasado, el presente y el futuro, desde memorias, historias, cosmovisiones e ideologías hasta utopías o distopías; narrativas e interpretaciones fruto del pensamiento humano que, en ciertas circunstancias y coyunturas importantes, resurgen para analizar y caracterizar procesos, proponiendo o esbozando posibilidades sobre el porvenir. En este artículo, se realiza una revisión provisional de los análisis y proyecciones sociológicas situadas y posicionadas, mediante escritos y declaraciones de pensadores contemporáneos considerados referentes en el marco de las ciencias sociales, con relación a la pandemia del año 2020. Se trata de presentar sus perspectivas y prospectivas de la dimensión social de la crisis según dos tendencias semánticas: las oportunidades y miradas esperanzadoras, y los riesgos y voces pesimistas; ello mediante un análisis documental de sus exposiciones y la clasificación de enfoques. Como resultado, cabe adelantar que la visión optimista es mayoritaria, aunque matizada, y que hay especial énfasis en la revisión de la vida social y su reordenamiento para un mundo mejor.
Study of Sustainable Development of Natural Resources in Economic Development of MP: Special Reference to SDGSs
Authors: Saifee Mazahir
Published: September 2021

Sustainable development (SD) has become a popular catchphrase in contemporary development discourse. However, in spite of its pervasiveness and the massive popularity it has garnered over the years, the concept still seems unclear as many people continue to ask questions about its meaning and history, as well as what it entails and implies for development theory and practice. In the present study, an attempt has been made to establish cause and effect relationship in between different land use patterns, total population, urban population and net state domestic products (NSDPs) for entire Madhya Pradesh (MP) from the year 1990-91 to 2000-01and to make an effective policy implications for sustainable forest management. The secondary information has been collected to fulfill the requirement of objectives. The purpose of this paper is to contribute to the discourse on SD by further explaining the paradigm and its implications for human thinking and actions in the quest for sustainable development. This is done through extensive literature review.
A Conceptual Study The Emerging Issues of Sustainable Development of Natural Resources in Economic Development
Authors: Saifee Mazahir
Published: September 2021

Sustainable development (SD) has become a popular catchphrase in contemporary development discourse. However, in spite of its pervasiveness and the massive popularity it has garnered over the years, the concept still seems unclear as many people continue to ask questions about its meaning and history, as well as what it entails and implies for development theory and practice. The exploitation of natural resources in India is still done in an unsustainable manner. The social-environmental impacts of mega projects are disdain following which people’s disappointment in the form of movements is a common phenomenon in the region. Owing to underdevelopment, the need for developmental activities is inevitable; however, the approach should focus on sustainable and inclusive growth so that the fulfilment of the basic requirements of the society is sustained at a minimal level while safeguarding the existing rich environmental resources and culture of the indigenous people. The purpose of this paper is to contribute to the discourse on SD by further explaining the paradigm and its implications for human thinking and actions in the quest for sustainable development.
Networks of Threats: Interconnection, Interaction, Intermediation
Authors: Theron Julien
Published: September 2021

The rapidly changing global security environment requires to constantly adapt our understanding of threats. The findings of this paper confirm that threats interact with each other on three levels. Security, conflict, war, and strategic studies converge to build a new qualitative theoretical framework for threat analysis. Shaping the global security environment, threats communicate on three levels. Firstly, the interconnection of agents with similar ideological and/or strategic motivations connects threats. Secondly, interaction exacerbates incidental threats through cooperation, competition, and convergence. Thirdly, intermediation occurs between antagonistic threats trying to achieve common intermediary objectives. These networks are driven by agents maximizing their impact and reveals the autonomization and socialization of threats. Tackling these networks requires a global approach and the mobilization of collective security.
Biomechanical changes in women with chronic pelvic pain: a case-control study
Authors: M. Elbesh Rovan , A. Hamada Hamada , A. Elanen Mohamed , M. Yousef Amel , Mohamed Shousha Tamer , Reda Mohamed Rania
Published: September 2021

Purpose

Chronic pelvic pain can influence women’s quality of life and activity levels; it can lead to several adverse side effects, such as changes in posture and biomechanical alignment. The purpose of this study was to determine the biomechanical changes that occur in women experiencing chronic pelvic pain, either cyclic or noncyclic.

Methods

A case-control study was conducted among 60 females from the Gynecology Physiotherapy Clinic of El-Hosary Women Health Care in 6th of October city. The participants were assigned into 3 groups: cyclic chronic pelvic pain group (A), noncyclic chronic pelvic pain group (B), and normal women group (C). An inclinometer was used to assess biomechanical changes in the angles of the cervical, thoracic, and lumbar region; furthermore, a pelvic inclinometer served to measure the pelvic inclination angle.

Results

Statistical analysis revealed that there was a significant increase in biomechanical variables at the lumbar, thoracic, and cervical angles in group B compared with groups A and C and in group A compared with group C. Moreover, there was a significant increase in right and left pelvic inclination angles in groups A and B compared with group C, and no significant difference was observed between groups A and B.

Conclusions

Biomechanical alignment changes are seen more frequently in women with noncyclic chronic pelvic pain and cyclic chronic pelvic pain than in normal women.
Die Novelle frisst ihre Kinder
Authors: Röhl Thomas
Published: September 2021

Nachdem das Bundeskabinett den Entwurf der Novelle des Verpackungsgesetzes verabschiedet hat, gibt es weiterhin noch viel Handlungsbedarf. Vor allem ein gesetzgeberischer Zwang pro Mehrwegverpackungen bei Serviceverpackungen wird von vielen Akteuren als kontraproduktiv betrachtet.
Hackfleisch nur noch im Flow-Pack
Authors: Deininger Sabrina
Published: September 2021

70 Prozent weniger Kunststoff, komplett recycelbare Materialen: Die süddeutsche Supermarktkette Feneberg mit Hauptsitz in Kempten bietet in knapp 80 Filialen SB-Hackfleischprodukte nicht mehr in der MAP-Schale an, sondern ausschließlich im Flow-Pack.
Rohstoffe händeringend gesucht!
Authors: Röhl Thomas
Published: September 2021

Eine ganze Reihe sich gegenseitig verstärkender Probleme bringen die Verpackungsbranche in ganz Europa unter Druck: Die gestiegenen Kosten für Rohstoffe aller Art, die Verknappung der vorgelagerten Lieferketten, Kostensteigerungen durch Covid-19 und dramatisch gestiegene Frachtkosten aufgrund der geringeren Verfügbarkeit von Containern sind nur einige Beispiele für eine Vielzahl destabilisierender Faktoren.
Was die Branche bewegt Kaum Raum für Zweifel
Authors: Röhl Thomas
Published: September 2021

Ein Ziel der Single-Use-Plastic-Richtlinie (SUP) der EU liegt in der Reduzierung der Vermüllung unserer Weltmeere. Dieser Punkt wird von der Richtlinie selbst als eine Schlüsselmaßnahme zur Erreichung des UN-Ziels für nachhaltige Entwicklung (Sustainable Development Goal 14) hervorgehoben.
Produktion rauf – Kosten runter
Authors: Röhl Thomas
Published: September 2021

Karteks zählt zu den führenden Herstellern von Faltkisten aus Wellpappe in Serbien – und ist hier nach Smurfit Kappa und DS Smith der drittgrößte Anbieter. Jetzt hat Karteks in eine Flachbettstanze Bobst Expertcut 1.6 investiert.
Vliesstoffoberfläche macht den Unterschied
Authors: Sachs Melanie
Published: September 2021

Um ein Produkt im Wellpappen-Direktdruck weiter zu verbessern, war ein Unterbau mit einfachem Positionierverhalten auf dem Druckzylinder die Lösung.
Für die Shisha nur das Beste
Authors: Röhl Thomas
Published: September 2021

Das Schweizer Unternehmen Toff Drehteile fertigt unter dem Label Toff Design Shishas hochwertige Wasserpfeifen im puristisch funktionalen Design. Damit die Premiumprodukte ohne Kratzer und Beschädigungen beim Kunden ankommen, setzt der Familienbetrieb auf eine neue E-Commerce-Verpackung.