bluuebunny/crossref_metadata_2025 huggingface dataset:
Water quality polluted by total suspended solids classified within an artificial neural network approach
Authors: Luviano Soto Itzel , Sánchez Yajaira Concha , Raya Alfredo
Published: December 2024

This study investigates the application of an artificial neural network (ANN) framework for analysing water pollution caused by solids. To address the challenge, we develop a convolutional neural network trained under a transfer learning strategy with AlexNet. We feed the network with pictures of samples of water with low, medium, and high concentrations of total suspended solids and achieve a high validation accuracy of 99.85% with a precision of 99.85%, which is highly competitive with other approaches. Our model demonstrates significant improvements in speed and reliability over conventional image processing methods, effectively predicting pollution levels. Our findings suggest that ANNs can serve as an effective tool for real-time monitoring and management of water pollution, facilitating proactive decision-making and policy formulation.
Probing the Mesenchymal Stem Cell Aging through In silico Assessment of Extracellular Vesicle-mediated miRNAs
Authors: Mi Ningning , Liu Xibin , Gao Yuhua , Bai Chunyu , Li Xiangchen
Published: December 2024

Introduction:

During mesenchymal stem cell (MSCs) aging, a decrease in its proliferation
and regenerative capacity occurs, which is implicated in human aging. The MSCs aging process is
regulated by genetics, metabolism, the external environment, and various complex pathways

Method:

The aging of MSCs during in vitro culture poses a major challenge for developing cell therapy
aimed at combating human diseases and aging. To identify the contributing factors underlying
MSCs aging, we obtained datasets of mRNA expression changes before and after aging from the
Gene Expression Omnibus (GEO) database and datasets of extracellular vesicles (EVs) microRNAs
(miRNAs) expression changes (GSE153752, GSE195634, and GSE226464). We conducted an indepth
analysis to screen the correlation between EVs-miRNAs and MSCs aging.

Result:

Our analysis identified significant differences in the expression of hsa-miR-146a-5p, hsamiR-
432-5p, hsa-miR-7706, hsa-miR-409-3p, and hsa-miR-17-5p in EVs before and after MSCs
aging. These differences arise from the post-MSCs aging activation of signaling pathways, such as
FOXO and P53, which promote the expression of hsa-miR-146a-5p, hsa-miR-432-5p, hsa-miR-7706,
hsa-miR-409-3p, and hsa-miR-17-5p.

Conclusion:

Subsequently, these miRNAs are transported to EVs upon binding to the RNA-binding
proteins A2BP1, SFRS2, MBNL1, EIF4B, and ACO1. This study used the correlation between
MSCs aging and specific EVs-miRNAs to predict MSCs aging during the culture process.
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots
Authors: Tu Binbin , Fu Xibei , Han Xiaowei , Wang Fei , Wu Baoju
Published: December 2024

Aims:

external interference and slow localization response. The primary objective is to
propose an algorithm that integrates admittance control and non-singular fast terminal sliding mode
control, verifying its effectiveness through simulation experiments while exploring its potential for
patent application.

Background:

Due to their versatility and efficiency, UAVs are increasingly utilized in various aerial
operations. However, they are susceptible to external disturbances, which may affect their stability
and accuracy during tasks such as contact operations. Additionally, inherent delays in localization
response speed may impact their performance in dynamic environments. Addressing these issues
is essential for improving the reliability and robustness of UAV-based systems.

Methods:

To achieve the objectives, the kinematics and dynamics of a hexacopter aerial carrier robotic
arm system were initially modeled. Subsequently, an external admittance controller was designed
to mitigate disturbances encountered during contact operations, achieving smooth control of
the robotic arm end-effector by adjusting the desired position to enhance system stability and disturbance
rejection. Additionally, to prevent performance degradation stemming from controller saturation,
an internal position control mechanism utilizing a non-singular fast terminal sliding mode
control algorithm was implemented. This approach enhances system robustness and convergence
speed, ensuring accurate positioning.

Results:

To validate the effectiveness and feasibility of the proposed control algorithm, numerical
simulations were conducted. The outer loop's admittance control exhibited a smoother control process,
particularly during sudden stiffness changes when the actuator contacts the environment. The
inner loop, employing Non-Singular Fast Terminal Sliding Mode Control (NFTSMC), improved
joint angle tracking speed by 41%-58% compared to PID control, and by 20%-50% compared to
traditional Sliding Mode Control (SMC). This algorithm demonstrated faster convergence rates and
smoother transitions, significantly reducing steady-state errors in contact force while exhibiting robustness
to environmental parameters. The findings indicate that the algorithm effectively addresses
the issues of external interference and sluggish localization response encountered by UAVs during
aerial operations.

Conclusion:

The algorithm based on admittance control and non-singular fast terminal sliding
mode control demonstrates superior performance compared to traditional sliding mode control and
PID control in mitigating external disturbances and enhancing the precision of UAV aerial operations.
This ensures the resilience to disturbances and the speed of localization response of the rotary-
wing flying robotic arm system during cleaning processes, thus enhancing its reliability and robustness
in dynamic environments.
Integrating Digital Twin Technology with AA7050 and AA5083 Alloys for Advanced Resistance Spot Welding Monitoring
Authors: R Girimurugan , Kumar Viranshu , D Magesh Babu , Shukla Anoop Kumar , L Girisha
Published: December 2024

Introduction:

To improve product design and production iteratively, virtual-real interaction
was made possible by using a Digital Twin (DT) to build an information mapping bridge between
the virtual and physical worlds. Digital twins are an important tool in the execution of intelligent
manufacturing. Resistance spot welding techniques are used to construct thin sheet structures
in many aerospace and automotive industries. The production of high-quality joints during resistance
spot welding is highly dependent on the fusion nugget growth process. Due to its large, integrated,
complex process, it is difficult to exact quality monitoring using physical models of resistance
spot welding.

Method:

This study investigates the utilization of digital twin (DT) technology for the purpose of
monitoring and enhancing resistance spot welding (RSW) operations, with a specific emphasis on
the welding of AA7050/AA5083 materials. A full digital twin model was created by merging realtime
data collecting and processing using wavelet threshold noise removal analysis.

Result:

The model effectively achieved synchronization with the physical welding process, providing
a comprehensive examination of the temperature distribution and the kinetics of nugget production
during Resistance Spot Welding (RSW). The digital twin demonstrated remarkable accuracy,
achieving a 96% success rate in measuring the diameter of the molten core. This greatly improved
the precision of assessing the quality of welding.

Conclusion:

These findings validate the digital twin's capacity as a pragmatic instrument for realtime
process control and optimization in intricate industrial settings, thus promoting the fusion of
virtual models with physical production processes.
Parasitic Diseases in Goats: Therapeutics and Control Measures
Authors: Gupta Snehil , Sharma Diksha , Gupta Surbhi , Kumar Rajender
Published: December 2024

Goats act as a crucial source of meat, milk, and wool for humans worldwide.
Due to their browsing and foraging activity, their health and production constantly
suffer from the threat of helminth infection and ectoparasitic infestation. However,
there is limited and scattered information on the therapeutics and control of parasites in
goats. The information available for the sheep and cattle industry is often reinforced in
the goat industry without any safety and efficacy trials of particular formulations in
goats. This chapter emphasizes the fact that goat metabolism differs widely from other
small ruminants. Therefore, the therapeutic dosage regimen of anthelmintics and other
oral medications in goats differs significantly from other animals. Secondly, refugia
must be maintained in the animal farms to maintain the efficacy of available drugs. The
emergence of anthelmintic and acaricide resistance can be delayed by using integrated
parasite management practices. Prudent implication of available therapeutics in light of
available scientific literature can significantly impact the livelihood of farmers engaged
in the goat industry.
Effectiveness of an Internet-Based, Self-Guided, Short-Term Mindfulness Training (ISSMT) Program for Relieving Depressive Symptoms in the Adult Population in China: Single-Blind, Randomized Controlled Trial
Authors: Zhu Tingfei , Zhang Liuyi , Weng Wenqi , Gan Ruochen , Sun Limin , Wei Yanping , Zhu Yueping , Yu Hongyan , Xue Jiang , Chen Shulin
Published: December 2024

Background

Depression is a significant global public health issue, and in China, access to mental health services remains limited despite high demand. Research has shown that mindfulness can effectively alleviate depressive symptoms and that telehealth solutions offer a promising avenue for addressing this service gap. Despite this potential, there are currently few studies in China focusing on short-term online mindfulness training. Most existing online mindfulness studies relied on traditional 8-week programs, which can be challenging for participant adherence due to limited accessibility and high dropout rates. Additionally, limited research exists on short-term online mindfulness interventions, and findings remain inconsistent.

Objective

This study aimed to develop and evaluate an internet-based, self-guided, short-term mindfulness training (ISSMT) program based on the Monitor and Acceptance Theory (MAT) to reduce depression symptoms.

Methods

The ISSMT program was delivered via an online platform, “Hi Emotion,” and was accessible to the general public. Interested individuals aged 18 years and older were randomized into either the ISSMT group or a wait-list control group. Participants in the ISSMT group received daily reminders to participate in a 15- to 20-minute session over a 14-day training period. Measurements, including mindfulness and depressive symptoms, were collected at baseline and weekly for the subsequent 3 weeks.

Results

A total of 205 adults participated in the 14-day online intervention. Linear mixed models were used to analyze both per-protocol (PP) and intention-to-treat (ITT) samples. Compared with the wait-list control group, participants in the ISSMT group showed significant improvements in mindfulness (Cohen d=0.44 for ITT; Cohen d=0.55 for PP) and reductions in depressive symptoms (Cohen d=0.50 for ITT; Cohen d=0.53 for PP). Furthermore, participants expressed high acceptance of this training format with a relatively low dropout rate (<40%).

Conclusions

The ISSMT program based on the MAT effectively enhanced mindfulness and alleviated depressive symptoms. This intervention could be considered for integration into psychosocial service systems to improve mental health outcomes and help bridge the gap between limited resources and the high demand for services in China. Future research should focus on personalizing these programs and incorporating advanced technologies to enhance their effectiveness and user engagement.

Trial Registration

Open Science Framework; https://doi.org/10.17605/OSF.IO/8P4V6
A Remotely Delivered Light-Intensity Physical Activity Intervention for Older Cancer Survivors: Protocol for a Feasibility Randomized Controlled Trial
Authors: Blair Cindy K , Brown-Glaberman Ursa , Walters Scott T , Pestak Claire , Boyce Tawny , Barriga Laura , Burgess Ellen , Tawfik Bernard , Killough Cynthia , Kinney Anita Y , Demark-Wahnefried Wendy , Meisner Angela L , Wiggins Charles L , Pankratz V Shane , Davis Sally
Published: December 2024

Background

Older cancer survivors face age- and treatment-related comorbidities, including physical functional impairment, which are exacerbated by physical inactivity and sedentary behavior. Regular physical activity can reduce this risk, yet less than 30% of older cancer survivors meet the recommended guidelines for physical activity.

Objective

This study aims to describe the design, methods, and rationale for a remotely delivered intervention that uses a whole-of-day approach to physical activity in older cancer survivors. This approach focuses on the accumulation of intermittent bouts of light-intensity activity throughout the entire day by disrupting and reducing sedentary activity. The intervention was guided by social cognitive and self-determination theories and incorporated motivational interviewing.

Methods

The 12-week Move for Your Health trial randomly assigned 64 older cancer survivors to a theory-based physical activity intervention or a waitlist control. A Fitbit (Google) activity tracker and smartphone app were used to promote awareness of activity levels and enable self-monitoring of both activity and inactivity in tandem with health coaching phone calls. Motivational interviewing was used to engage participants and tailor strategies to achieve goals during the 12-week intervention. Data were collected at baseline, immediately after the intervention, and at longer-term follow-up (3 months thereafter). Feasibility outcomes included recruitment, retention, adherence, adverse events, and acceptability. Other outcomes included obtaining the parameter estimates for changes in physical function, physical performance, physical activity, sedentary behavior, and quality of life.

Results

Recruitment for the Move for Your Health randomized controlled trial was completed in June 2023. Data collection was completed in March 2024. Data analyses are ongoing.

Conclusions

The results of this trial will provide information on the feasibility of implementing this intervention in the target patient population, as well as data that will provide information about the potential impact of the intervention on the outcomes. Both of these outcomes will inform the design of a larger randomized controlled trial to more fully test a physical activity intervention in an older cancer survivor population.

Trial Registration

ClinicalTrials.gov NCT05582889; https://clinicaltrials.gov/study/NCT05582889

International Registered Report Identifier (IRRID)

DERR1-10.2196/59504
Close-Up on Ambulance Service Estimation in Indonesia: Monte Carlo Simulation Study (Preprint)
Authors: Brice Syaribah N , Boutilier Justin J , Palmer Geraint , Harper Paul R , Knight Vincent , Tuson Mark , Gartner Daniel
Published: December 2024

BACKGROUND

Emergency medical services have a pivotal role in giving timely and appropriate responses to emergency events caused by medical, natural, or human-caused disasters. To provide adequate resources for the emergency services, such as ambulances, it is necessary to understand the demand for such services. In Indonesia, estimates of demand for emergency services cannot be obtained easily due to a lack of published literature or official reports concerning the matter.

OBJECTIVE

This study aimed to ascertain an estimate of the annual volume of hospital emergency visits and the corresponding demand for ambulance services in the city of Jakarta.

METHODS

In this study, we addressed the problem of emergency services demand estimation when aggregated detailed data are not available or are not part of the routine data collection. We used survey data together with the local Office of National Statistics reports and sample data from hospital emergency departments to establish parameter estimation. This involved estimating 4 parameters: the population of each area per period (day and night), the annual per capita hospital emergency visits, the probability of an emergency taking place in each period, and the rate of ambulance need per area. Monte Carlo simulation and naïve methods were used to generate an estimation for the mean ambulance needs per area in Jakarta.

RESULTS

The results estimated that the total annual ambulance need in Jakarta is between 83,000 and 241,000. Assuming the rate of ambulance usage in Jakarta at 9.3%, we estimated the total annual hospital emergency visits in Jakarta at around 0.9-2.6 million. The study also found that the estimation from using the simulation method was smaller than the average (naïve) methods (P<.001).

CONCLUSIONS

The results provide an estimation of the annual emergency services needed for the city of Jakarta. In the absence of aggregated routinely collected data on emergency medical service usage in Jakarta, our results provide insights into whether the current emergency services, such as ambulances, have been adequately provided.
Appropriately Matching Transport Care Units to Patients in Interhospital Transport Care: Implementation Study (Preprint)
Authors: Hasavari Shirin , Esmaeilzadeh Pouyan
Published: December 2024

BACKGROUND

In interfacility transport care, a critical challenge exists in accurately matching ambulance response levels to patients’ needs, often hindered by limited access to essential patient data at the time of transport requests. Existing systems cannot integrate patient data from sending hospitals’ electronic health records (EHRs) into the transfer request process, primarily due to privacy concerns, interoperability challenges, and the sensitive nature of EHR data. We introduce a distributed digital health platform, Interfacility Transport Care (ITC)–InfoChain, designed to solve this problem without compromising EHR security or data privacy.

OBJECTIVE

This study aimed to detail the implementation of ITC-InfoChain, a secure, blockchain-based platform designed to enhance real-time data sharing without compromising data privacy or EHR security.

METHODS

The ITC-InfoChain platform prototype was implemented on Amazon Web Services cloud infrastructure, using Hyperledger Fabric as a permissioned blockchain. Key elements included participant registration, identity management, and patient data collection isolated from the sending hospital’s EHR system. The client program submits encrypted patient data to a distributed ledger, accessible to the receiving facility’s critical care unit at the time of transport request and emergency medical services (EMS) teams during transport through the PatienTrack web app. Performance was evaluated through key performance indicators such as data transaction times and scalability across transaction loads.

RESULTS

The ITC-InfoChain demonstrated strong performance and scalability. Data transaction times averaged 3.1 seconds for smaller volumes (1-20 transactions) and 6.4 seconds for 100 transactions. Optimized configurations improved processing times to 1.8-1.9 seconds for 400 transactions. These results confirm the platform’s capacity to handle high transaction volumes, supporting timely, real-time data access for decision-making during transport requests and patient transfers.

CONCLUSIONS

The ITC-InfoChain platform addresses the challenge of matching appropriate transport units to patient needs by ensuring data privacy, integrity, and real-time data sharing, enhancing the coordination of patient care. The platform’s success suggests potential for regional pilots and broader adoption in secure health care systems. Stakeholder resistance due to blockchain unfamiliarity and data privacy concerns remains. Funding has been sought to support a pilot program to address these challenges through targeted education and engagement.
Quality of an Assistive Technology Web App for Primary Care Physicians Serving Older Adults: A Concurrent Mixed Methods Study (Preprint)
Authors: Orellano-Colon Elsa M , Bonilla-Díaz Wency , Revilla-Orellano Radamés , Mejías-Castro Jesús , Roche-Lima Abiel
Published: December 2024

BACKGROUND

Older Latinos living in Puerto Rico (PR) experience significantly higher rates of functional disabilities (FDs) (27.8%) compared to older adults in the continental US (13.3%). While assistive technologies (AT) can improve daily function and support aging in place, primary care physicians (PCPs), who are essential in addressing FDs resulting from chronic diseases, often lack knowledge about AT devices and services. The Mi Guía de Asistencia Tecnológica (MGAT; My Assistive Technology Guide) web application was empirically developed to address this gap by providing comprehensive information and videos about AT devices for older adults with functional difficulties in daily living activities.

OBJECTIVE

Assess the quality of MGAT among PCPs and describe their experiences using this tool to increase older Latino access to AT.

METHODS

Ten PCPs participated in this usability project, receiving MGAT training prior to a 30 day implementation period. Using a concurrent mixed-method design, data were collected using the User Version of the Mobile User Application Rating Scale (uMARS) and individual interviews. The analysis included descriptive statistics and a directed content analysis.

RESULTS

The MGAT received high overall uMARS objective quality ratings (mean 4.06 ± 1.05), with information scoring highest (mean 4.60 ± 0.51) and engagement lowest (mean 3.34 ± 1.51). The subjective quality was also high (mean 3.9 3.34 ± 1.19), with perceived impact receiving the highest score (mean 4.82; SD 0.39). PCPs reported positive experiences using MGAT for the education of AT devices and services and provided recommendations for improving the tool and integrating it into medical practice.

CONCLUSIONS

The high-quality and usefulness ratings suggest MGAT could be an effective tool for PCPs in managing older adults' FDs. Future research should evaluate the effectiveness of MGAT in managing FDs among older adults.

CLINICALTRIAL
Discovering Topics and Trends in Artificial Intelligence Chatbots in Medicine: Using Latent Dirichlet Allocation Topic Modeling (Preprint)
Authors: Ni Ming Yue , Jiang Yun Xia , Li Ming Run , Lin Xin , Xu Shao Hua , Zhou Yun Ping
Published: December 2024

BACKGROUND

With the widespread adoption of the internet and smart devices, chatbots have emerged as significant auxiliary tools for public health activities. Despite the increasing application of chatbots in the medical field, comprehensive assessments of research topics and trends in this area remain relatively scarce.

OBJECTIVE

This study analyzed the application topics of chatbot technology in the medical field and explored the trends of these topics across different time periods, various journals, and different countries.

METHODS

In this study, a bibliometric approach was used to systematically search the PubMed, CINAHL, Web of Science and Embase databases for literature on medicine and chatbots between 2004 and 2024. By applying Latent Dirichlet Allocation (LDA) topic modeling, the study identified and analyzed the thematic applications of chatbots in the medical field, and explored the temporal evolution of these topics as well as their distribution characteristics across journals and countries.

RESULTS

We ultimately identified 3,029 articles for analysis. Utilizing the Latent Dirichlet Allocation (LDA) topic modeling technique, we identified nine core topics from the abstracts: ChatGPT medical quiz accuracy research, digital healthcare support assistants, mental health intervention research, epidemic health conversation application research, cancer patient diagnosis and treatment care, artificial intelligence (AI) healthcare education potential research, natural language processing models, human-computer interaction emotion research, and AI reading assistance systems. This study also found that these topics have shown diverse developmental trajectories over time, reflecting the evolution of research interests. In addition, researchers from different journals and countries have shown significant differences in the topics they focus on.

CONCLUSIONS

This study analyzed the topic distribution, temporal trends, journal, and country distribution characteristics of chatbots in the medical field. The results revealed popular and less researched topics, as well as emerging directions and trends, providing researchers with a tool for rapid identification. These findings not only provide guidance for researchers in selecting research directions but also offer references for journals and countries in determining research priorities, formulating strategic plans, and promoting international collaborative research.
PREDICTIVE VALUE OF TUMOR SIZE ON THE INCIDENCE OF PERITUMORAL EDEMA ON PRE-SURGERY HEAD MRI OF MENINGIOMA PATIENTS
Authors: Pangestu Rahmawati Dianing , Faisal Arif , Utomo Bambang Purwanto
Published: December 2024

Background : Peritumoral brain edema (PTBE) of meningioma causes morbidity, poor clinical outcomes and complicates surgery. Tumor size correlates with the incidence of PTBE. However, the threshold value for tumor size that cause PTBE in meningioma has not been widely studied. Objective: To determine the threshold value for meningioma size that can predict the incidence of peritumoral edema in general and based on specific intracranial locations on pre-operative head MRI.Methods: This is a cross sectional study on patients with intracranial meningioma who had undergone head MRI imaging at Dr.Sardjito Hospital in the period of 2018-2022 retrospectively. An analysis was carried out to find the threshold value for meningioma size and the prevalence ratio to predict the incidence of PTBE. Results: The cut-off volume for intracranial meningioma was >44 cm3 with RP of 3.61 (p=0.01) in general. Simultaneously, large tumor volume (≥44 cm3) has the strongest correlation to the incidence of peritumoral edema (p=0.01). The cut-off volume for meningioma in supratentorial non-skull base was >22 cm3 with RP of 2.54, while in supratentorial skull base was >54 cm3 with RP of 23.33 (p=0.01). The cut off volume for meningioma in infratentorial region was >19.75 cm3 with RP 3.0 (p=0.52). Conclusion: The cut-off value for intracranial meningioma volume to predict the incidence of peritumoral edema is 44 cm3. There are differences in the cut-off values of meningioma volume and prevalence ratios based on specific intracranial locations to predict the incidence of PTBE in meningioma.
Qualitative analysis of Indonesian hospital pharmacist’s perceptions of their roles and behaviour during the covid-19 pandemic
Authors: Prasetyaningrum Dina Ayu , Purwonugroho Tunggul Adi , Mustikaningtia Ika , Ilma Dewi Latifatul , Sholihat Nia Kurnia , Maharani Laksmi
Published: December 2024

AbstractBackground: Pharmacists are health workers who play an important role in dealing with COVID-19 pandemic problems. This study explored the hospital pharmacist's perception of their roles and behaviours and the influence factors during the COVID-19 pandemic period.Material and Methods: The research was conducted using phenomenological qualitative methods through in-depth online interviews using an online meetings platform. Informants were taken until the data was saturated. Credibility tests by member checking, dependability, and confirmability tests were performed to ensure data validity. The results of the interviews then were analyzed by thematic analysis.Results: Eight informants were included with 5 emerging themes revealed from this study. The theme consists of the pharmacist's high commitment to his important role as a team member of the healthcare provider in providing the best service by adapting their services, ensuring rational therapy for COVID-19 patients, and maintaining the availability of medicines, medical devices, and consumable medical materials. Furthermore, pharmacists described some innovation strategies, like drug delivery for outpatients and telepharmacy services. The supporting factors for pharmacists in their services were interprofessional collaboration between pharmacists and other healthcare providers. Support from colleagues, hospital management, government, donations and technology were also revealed as positive factors. The barrier factors included uncertain pandemic conditions, pharmacists who were exposed to the virus and the mental health condition of healthcare professionals during the pandemic.Conclusion: Pharmacists have a strong commitment to playing a crucial part in the healthcare team in offering the most treatment possible and providing management work. They created some innovative initiatives to tackle the COVID-19 burden. Supportive and barrier factors that affect pharmacist performance during pandemics were also disclosed and examined in this paper.Keywords:
LUNG CANCER CHEMOTHERAPY REGIMEN ADMINISTRATION STUDY AT THE ACADEMIC HOSPITAL OF GADJAH MADA UNIVERSITY
Authors: Oktariyanto Efel Erlambang , Yasin Nanang Munif , Puspitasari Ika
Published: December 2024

Background: One of the main ways to treat lung cancer is through chemotherapy regimens. Due to the complexity of lung cancer pathophysiology, the variability of chemotherapy given tends to cause drug interactions and toxicity in patients.Objective: Based on this, this study aims to determine the characteristics of lung cancer patients and identify chemotherapy administration patterns based on the NCCN therapy guidelines, identify interactions and side effects of chemotherapy that occur in patients diagnosed with lung cancer who are undergoing outpatient therapy at the Universitas Gadjah Mada Academic Hospital.Method: This research was carried out with a case-series design, namely by conducting a study using descriptive methods that provide an overview of patient characteristics, chemotherapy regimen patterns and their conformity to NCCN guidelines, potential drug-drug interactions (DDIs), and the incidence of side effects experienced by patients. Data was collected retrospectively through medical records of lung cancer patients undergoing outpatient treatment in the period April 2022 – April 2023 who met the inclusion and exclusion criteria.Result: There were a total of 27 patients in this study with patient characteristics predominantly in the elderly age range (> 60 years), 18 patients (66.7%), with exon 19 mutation NSCLC lung cancer type (n = 13; 92.6%), stage IV (n = 25 ; 92.6%), as well as non-smoking patients (n = 15 ; 55.6%). Chemotherapy regimen patterns at Gadjah Mada University Academic Hospital for lung cancer patients included afatinib (n = 14; 51.9%), gefitinib (n = 12; 44.4%), and cisplatin pemetrexed (n = 1; 3.7 %) with conformity reaching 100% in the accuracy of indications, dosage and usage information. In this study, it was identified that there were 2 Potential DDIs that occurred in 1 patient (3.7%) with respective risks, namely C and B which included cisplatin-furosemide and cisplatin-ondansetron interactions. Side effects were known to occur in almost all patients (n = 23; 85.2%) where side effects in the form of skin toxicity and diarrhoea were the two most frequently identified types of side effects with a percentage of 59.3% (n = 16). and 40.7% (n = 11).Conclusion: More than 90% of NSCLC showed exon 19 mutation. The most chemotherapy given to the patients was afatinib. There were a potential interaction between cisplatin and either furosemide or ondansetron.
Relationship between Microvascular Complications and Elevated Neutrophil-to-Lymphocyte Ratio in Patients with Diabetes Mellitus
Authors: Rico-Chávez Pedro , Pérez-Pérez Mireya , Reyes-Jiménez Olivia
Published: December 2024

Objective: To evaluate the relationship between microvascular complications and elevated neutrophil-to-lymphocyte ratio (NLR) values in patients with type 2 diabetes mellitus (T2DM) from a family medicine unit. Methods: A cross-sectional analytical study was conducted at Family Medicine Unit 92 of the Mexican Institute of Social Security. A total of 232 medical records of T2DM patients were analyzed through probabilistic sampling. A data collection form, designed by the researchers, was used to collect sociodemographic, biochemical, and clinical variables, which were analyzed with GraphPad Prism 10 using χ2 and Student’s t-tests. Results with a p-value <0.05 were considered statistically significant. Results: NLR was calculated for each medical record, and it was found that 51 patients (22%) had elevated NLR values. Elevated nlr was associated with sex, hypertension, and poor glycemic control (p<0.05) but not with body mass index (BMI), age, and duration of T2DM. A statistically significant relationship was observed between elevated nlr and the presence of microvascular complications such as nephropathy, neuropathy, cardiopathy, and retinopathy (p<0.05). Logistic regression analysis showed a significant association between elevated NLR and diabetic cardiopathy (OR: 7.93, 95% CI, 3.29-20.33, p<0.05). Conclusion: Elevated NLR values were associated with the presence of microvascular complications in t2dm patients, suggesting that nlr may be useful as a biomarker for managing diabetic patients in family medicine consultations.
Govorno-jezična obrada tipičnosti u dihotomiji semantičkih kategorija “živo/neživo”
Authors:   Faculty of Humanities and Social Sciences, University of Zagreb, Croatia, Sekulić Sović Martina
Published: December 2024

Cilj ove studije bio je na temelju zadatka govorno-jezične produkcije i zadatka procjene tipičnosti identificirati razlike u udjelu visokotipičnih, odnosno niskotipičnih riječi između leksičko-semantičkih kategorija koje označavaju prirodne koncepte (domaće životinje, ptice, voće, povrće i cvijeće) i kategorija koje označavaju artefakte (odjeća, namještaj, prijevozna sredstva, alati i glazbeni instrumenti). Rezultati ovog istraživanja pokazali su da je kod većine leksičko-semantičkih kategorija visoka tipičnost dominantna kod živih koncepata (domaće životinje, ptice, voće, povrće), a niska tipičnost kod neživih koncepata (odjeća, prijevozna sredstva i alati). Daljnja analiza pokazala je da leksičko-semantička kategorija domaće životinje ima značajno veći udio visokotipičnih riječi, dok kategorija alati ima značajno veći udio niskotipičnih riječi. Na temelju tih nalaza možemo zaključiti da leksičko-semantička obrada tipičnosti i živosti ima važnu ulogu u govorno-jezičnoj produkciji i percepciji i kod zdravih govornika i u metodološkom izboru materijala za ispitivanje atipičnih promjena jezika.
Govorni proces u frazeologiji: somatski frazemi sa sastavnicom jezik/tongue/Zunge
Authors: Sarić Ana
Published: December 2024

Cilj provedenoga istraživanja bio je utvrditi koja se obilježja govornog procesa i artikulacije odražavaju u somatskim frazemima sa sastavnicom jezik u hrvatskom, engleskom i njemačkom jeziku. Metodom kontrastivne analize nastojalo se utvrditi razinu formalne i semantičko-konceptualne ekvivalencije unutar trojezičnoga korpusa, kao i motivacijske mehanizme koji sudjeluju u oblikovanju i procesiranju njihova značenja. Dobiveni rezultati pokazali su značajna podudaranja, ali i različitosti u domeni motivacije i leksikalizacije koncepata vezanih uz govorni proces i artikulaciju u trima jezicima. Riječ je o temeljnim obilježjima i fazama govornog procesa kao što su fluentnost ili disfluentnost u govoru, poticaj i želja za govorom, kao i šutnja kao izostanak ili prestanak govora. Zaključilo se kako su ustanovljene sličnosti primarno određene univerzalnom funkcijom jezika kao organom govora, dok različitosti govore u prilog jezičnoj raznolikosti i poimanju frazema kao kulturno označenih izraza.
Upotreba diskursnih markera u glasovnim porukama na odabranim primjerima korpusa Les Vocaux
Authors:   Faculty of Philosophy, University of Sarajevo, Šišić Emir
Published: December 2024

U ovom radu analizirat će se upotreba diskursnih markera u spontanom govoru na suvremenom francuskom jeziku na temelju jednojezičnoga usmenog korpusa Les Vocaux na sveučilištima u Strasbourgu, Lorraineu i Liègeu. Analiza korpusa obuhvaća 745 audiodokumenata, odnosno više od deset sati glasovnih poruka koje su snimljene mobilnim aplikacijama. Rad će pokušati dokazati da diskursni markeri imaju ulogu artikulatora u govornim iskazima na francuskom jeziku. Iako se radi o neobaveznim partikulama u govoru na sintaktičkom planu, one su vrlo česte i važne su u primanju poruke na pragmatičkom planu. S obzirom na opsežnost korpusa i frekvenciju upotrebe markera, analizirat ćemo upotrebu samo jedanaest onih koji su najprisutniji u korpusu: du coup, genre, ben, mais, enfin, en fait, bon, voilà, après, quoi, donc. Rezultati istraživanja pokazuju da navedeni diskursni markeri imaju različite uloge na makrosintaktičkom planu te da, iako predstavljaju periferne elemente govora, doprinose razvoju i organizaciji ilokucijske snage.
Linguistics/healthcare interface: Research-based development
Authors:   Faculty of Humanities and Social Sciences, University of Zagreb, Croatia, Kovač Hrvoje
Published: December 2024

Upravo je pokretanje novoga studija poslužilo kao prigoda i motivacija za međunarodni panel Linguistics/healthcare interface: Research-based development / Sučelje filologije i zdravstva: razvoj utemeljen na istraživanjima, koji se održao 17. lipnja 2024. godine u popodnevnim satima na spomenutome zagrebačkom Filozofskom fakultetu, a u zajedničkoj organizaciji Odsjeka za fonetiku i Odsjeka za lingvistiku. S osnovnim ciljem informiranja akademske zajednice i šire javnosti o sadržaju i primjenjivosti novoga studijskog programa, na panelu je govorilo četvero uglednih znanstvenika iz Hrvatske i inozemstva, koji su primjerima iz vlastita rada zorno prikazali izazove na sučelju filologije i zdravstva na koje klinička lingvistika i fonetika mogu odgovoriti.
EXPLORING THE LEVEL OF SELF-CONFIDENCE AMONG STUDENTS WITH DIFFERENT SPEAKING PERFORMANCE
Authors: Lestari Linda Dwi Ayu , Hidayati Kuni Hikmah , Laeli Anita Fatimatul
Published: December 2024

This study aimed to investigate the variation of students' self-confidence level in their speaking performance in English. Using a qualitative approach, live experiences, and influencing factors related to self-confidence in speaking English were explored. Data were collected through classroom observations, reflective journals, and interviews to get a deep understanding of participants’ perspectives and behavior. This research was conducted at an English course located in Kaliwates, Jember. The sample consists of two male students and two female students, all at the same CEFR level (A2 Elementary), but with varying levels of self-confidence and speaking performance. The results showed that students with low self-confidence can achieve high scores in speaking performance, while students with high self-confidence do not necessarily achieve high scores. They may still receive a low score in speaking performance, even if they have a high level of self-confidence.
Construindo a soberania sanitária no Mercosul: a experiência do curso de desenvolvimento e produção de vacinas
Authors: Tobar Sebastián , Carlos Santos da Costa Jorge , Nakamura  Gouvea Mirian , Alberto Medeiros Marco , Fernandes Delgado Isabella
Published: December 2024

Introduction: This paper reports on the experience of the Vaccine Development and Production Course, an initiative promoted by Fiocruz within the framework of the MERCOSUR Health Ministers’ Meetings. The experience was developed in the second half of 2023, with the participation of students from Argentina, Brazil, Paraguay, and Uruguay as member states of the bloc and Chile as an associate state. Objective: To support the hypothesis that we will only be able to advance health sovereignty in the field of vaccines if we simultaneously implement sovereignty in terms of strategy and the process of training human resources, articulating the region’s capabilities in a network. Method: This is a report that presents reflections onhealth sovereignty in the production of biological  products, based on a training experience that involved  the mobilisation of existing capacities at Fiocruz, Instituto Butantan and Nortec, based on synchronous remote classes and personal technical visits. Results: Details of this experience were presented and based on this, we sought to outline appropriate strategies for continuing professional development in the region, with the aim of achieving health sovereignty in terms of regional vaccine production with a view to self-sufficiency. Conclusions: It is noted that despite the language barriers and institutional differences between the bloc and the associated countries, the evaluation carried out at the end of the course confirms the relevance and the need to expand experiences such as the one developed. The need to create capacities in the region to effectively achieve health sovereignty is evident, as well as the importance of incorporating some strategic themes identified by the students to continue the qualification of professionals in the region, in a continuous and permanent training process.
The Significance of Location: Practicing American History in Sweden
Authors: Blanck Dag
Published: December 2024

This article deals with the teaching of American history in Sweden. It focuses on developments at Uppsala University where a course in American history has been taught since 1996, as a part of our American studies sequence. Placing it within the larger context of doing American studies in Sweden, it traces the development of the course discusses important topics taught and the challenges of finding suitable reading materials for students enrolled in the course.
EKSPLORASI DAN SINERGI VISUAL DALAM KOREOGRAFI TARI DI KUALA LUMPUR EXPLORATION AND VISUAL SYNERGY IN DANCE CHOREOGRAPHY IN KUALA LUMPUR
Authors: Samsudin Muhammad , Samsuddin Mohd Effindi
Published: December 2024

Kajian kualitatif ini mengeksplorasi proses kreatif antara koreografer dan seniman multimedia dalam menciptakan elemen koreografi yang mempunyai projeksi visual. Fokus penulisan ialah pada aspek motivasi koreografer dalam menghasilkan projeksi visual di dalam koreografi. Kajian ini melibatkan tiga produksi koreografi di Kuala Lumpur yang menggabungkan tari dan projeksi visual. Data dikumpulkan melalui temu bual dengan empat koreografer dan tiga seniman multimedia, serta pemerhatian dan penelitian dokumen. Penulisan ini mengadaptasi teori proses kreatif dan sinergi koreografi dan visual dalam menganalisis proses kreatif eksplorasi koreografi terbaru yang ditampilkan di Malaysia. Penulisan ini mengemukakan hasil dapatan yang menghubungkait dan menghuraikan corak proses pemikiran kreatif yang dirangkakan dalam karya koreografi terkini.
SOROTAN KAJIAN ANTROPOLOGI BUDAYA MASYARAKAT MELAYU DI KELANTAN A REVIEW OF CULTURAL ANTHROPOLOGY STUDIES ON THE MALAY COMMUNITY IN KELANTAN
Authors: Fan Yang , Silahudin Shafa'atussara
Published: December 2024

Artikel ini bertujuan untuk menganalisis kajian lepas dalam bidang antropologi budaya yang telah dilakukan di negeri Kelantan. Objektif kajian ini adalah untuk memberi gambaran keseluruhan terhadap tema utama yang dikaji dalam bidang antropologi budaya di Kelantan serta mengenal pasti kekurangan dalam kajian terdahulu dan cadangan bagi penyelidikan masa depan. Permasalahan kajian ini ialah jurang pengetahuan lantaran perkembangan terbaharu yang belum dikaji dalam literatur yang sedia ada. Pendekatan ini justeru mengenal pasti isu yang memerlukan penelitian lanjut untuk menghasilkan pemahaman yang menyeluruh. Kajian ini mendapati terdapat empat tema utama yang diberi perhatian. Ini meliputi struktur sosial dan ekonomi, adat-istiadat masyarakat Melayu di Kelantan, kesenian tradisi, dan hubungan dan integrasi budaya antara etnik yang berbeza di Kelantan. Kajian ini menggariskan keistimewaan negeri Kelantan dari segi ekonomi, perkembangan politik, budaya, adatistiadat, gaya hidup, hubungan etnik dan dialek. Dapatan kajian juga menunjukkan masyarakat Melayu Kelantan dapat menyesuaikan diri menghadapi cabaran moden meskipun masih mengekalkan budaya tradisi. Daya penarik bagi penyelidik tempatan dan antarabangsa menjalankan kajian dalam bidang antropologi budaya di Kelantan ialah negeri ini kaya dengan sumber sejarah, budaya dan warisan masyarakat yang berbeza dari negeri-negeri lain di Malaysia. Kajian ini menegaskan kepentingan pemahaman mendalam terhadap elemen budaya dan sosial yang bukan sahaja menambah kepada literatur antropologi budaya tempatan, malah memberi manfaat dalam memahami kerencaman budaya masyarakat Melayu. Negeri Kelantan menawarkan konteks penyelidikan yang kaya dengan nilai budaya yang tidak hanya menarik bagi kajian akademik tetapi berguna untuk merangka dasar yang menyokong pemeliharaan budaya tempatan.
A relação entre pré-escola e família em tempos de pandemia
Authors: Brandão Joyce Lima , Silva Marta Regina Paulo da
Published: December 2024

A construção e manutenção dos vínculos entre famílias e instituições educacionais representaram um desafio significativo durante o período pandêmico. Este artigo apresenta os resultados de uma pesquisa de mestrado que investigou a influência desse momento histórico na Educação Infantil. O objetivo foi o de compreender a relação entre família e pré-escola durante a pandemia. A pesquisa, de natureza qualitativa e exploratória, utilizou entrevistas semiestruturadas com professoras e responsáveis pelas crianças como principal procedimento metodológico. Os resultados indicaram que tanto os familiares quanto as docentes precisaram se adaptar ao ensino remoto, (re)formulando estratégias de interação mediadas por tecnologias digitais para preservar os vínculos e implementar propostas pedagógicas com as crianças. O estudo também revela o impacto da pandemia nas rotinas diárias, particularmente, pelo aumento da carga de trabalho. Apesar das dificuldades enfrentadas, as participantes destacaram que algumas ações foram bem-sucedidas na consolidação da parceria entre família e pré-escola e sugeriram que essas práticas devam ser incorporadas ao atendimento presencial.
Migracije u drugom desetljeću 18. stoljeća između južnoga Prekodunavlja i hrvatskih krajeva
Authors: Gőzsy Zoltán , Lovaš Eldina
Published: December 2024

U radu se na temelju transmigracijskoga popisa koji je najvjerojatnije nastao 1717. i 1718. godine, pomoću kvantitativne, kvalitativne i statističke metode, analiziraju preseljavanja kmetova iz Šomođske županije na područje Hrvatske. Analiza obuhvaća broj, podrijetlo i mjesto naseljavanja zavisnih seljaka, kao i udaljenost između spomenutih naselja. Unatoč tomu što spomenuti popis ne navodi uzroke njihove migracije, pokušat će ih se utvrditi i uklopiti ih u migracijske trendove u prvim desetljećima 18. stoljeća.