bluuebunny/crossref_metadata_2025 huggingface dataset:
Postabortion Contraceptive Acceptance Rate and Its Determinants among Women Receiving Abortion Service before Discharge from the Health Facilities in Harar, Eastern Ethiopia
Authors: Atnafu Endalkachew , Geda Biftu , Oljira Lemessa , Atnafe Genanaw , Tamiru Dawit , Birhanu Abdi , Tiruye Getahun , Kibret Haregeweyn , Debella Adera
Published: January 2022

Background. Annually, around 121 million unintended pregnancies occur in the world and more than 73 million encountered abortion. Ethiopia is also losing 19.6% of mothers due to unsafe abortion. Despite that postabortion contraceptive service is a climactic entry point for the prevention of unwanted pregnancy and associated deaths, the service magnitude and determinants immediately before discharge are not characterized well in Ethiopia. Hence, this study aimed to assess the magnitude of postabortion contraceptive utilization and associated factors among women receiving abortion care service before being discharged from health facilities in Harar, Eastern Ethiopia. Methods. A facility-based cross-sectional study was conducted among 390 women receiving abortion care services. At discharge, data about contraceptive acceptance and related maternal characteristics were collected. A binary logistic regression model was used to assess the association between independent and dependent variables (postabortion contraceptive utilization). Analysis was done with SPSS 22. Statistical significance was considered at

P
<
0.05

. Result. The overall prevalence of postabortion contraceptive utilization was 81.5% (95% CI: 77.9, 85.4). Being unmarried (AOR, 0.05; 95% CI (0.02, 0.16)), having no history of previous abortion (AOR, 0.11; 95% CI (0.04, 0.34)), being multigravida (AOR 8.1; 95% CI (2.20, 13.40), lacking desire to have an additional child (AOR, 6.3; 95% CI (2.65, 15.34), and history of family planning use (AOR, 17.20; 95% CI (6.5, 38.60)) were determinants of postabortion contraceptive utilization before being discharged from the health facilities. Conclusion. Postabortion contraceptive utilization in Harar health facilities still needs improvement as per the WHO and national recommendations. Therefore, the family planning provision strategies should be convincing and friendly, especially for unmarried mothers, and those who had no history of abortion should be counseled in friendly and systematically convincing schemes for enabling them to take the service before discharge from the health facility.
Timed Automaton-Based Quantitative Feasibility Analysis of Symmetric Cipher in Embedded RTOS: A Case Study of AES
Authors: Ke Yawen , Xia Xiaofeng
Published: January 2022

The real-time operating system (RTOS) has a wide range of application domains and provides devices with the ability to schedule resources. Because of the restricted resources of embedded devices and the real-time constraints of RTOS, the application of cryptographic algorithms in these devices will affect the running systems. The existing approaches for RTOS ciphers’ evaluation are mainly provided by experimental data performance analysis, which, however, lack a clear judgment on the affected RTOS performance indicators, such as task schedulability, bandwidth, as well as a quantitative prediction of the remaining resources of RTOS. By focusing on task schedulability in RTOS, this paper provides a timed automaton-based quantitative approach to judge the feasibility of ciphers in embedded RTOS. First, a cryptographic algorithm execution overhead estimation model is established. Then, by combining the overhead model with a sensitivity analysis method, we can analyze the feasibility of the cryptographic algorithm. Finally, a task-oriented and timed automaton-based model is built to verify the analysis results. We take AES as a case study and carry out experiments on embedded devices. The experimental results show the effectiveness of our approach, which will provide specific feasibility indicators for the application of cryptographic algorithms in RTOS.
Big Data Precision Marketing Approach under IoT Cloud Platform Information Mining
Authors: Li Wang
Published: January 2022

In this article, an in-depth study and analysis of the precision marketing approach are carried out by building an IoT cloud platform and then using the technology of big data information mining. The cloud platform uses the MySQL database combined with the MongoDB database to store the cloud platform data to ensure the correct storage of data as well as to improve the access speed of data. The storage method of IoT temporal data is optimized, and the way of storing data in time slots is used to improve the efficiency of reading large amounts of data. For the scalability of the IoT data storage system, a MongoDB database clustering scheme is designed to ensure the scalability of data storage and disaster recovery capability. The relevant theories of big data marketing are reviewed and analyzed; secondly, based on the relevant theories, combined with the author’s work experience and relevant information, a comprehensive analysis and research on the current situation of big data marketing are conducted, focusing on its macro-, micro-, and industry environment. The service model combines the types of user needs, encapsulates the resources obtained by the alliance through data mining for service products, and publishes and delivers them in the form of data products. From the perspective of the development of the telecommunications industry, in terms of technology, the telecommunications industry has seen the development trend of mobile replacing fixed networks and triple play. The development of emerging technologies represented by the Internet of Things and cloud computing has also led to technological changes in the telecommunications industry. Operators are facing new development opportunities and challenges. It also divides the service mode into self-service and consulting service mode according to the different degrees of users’ cognition and understanding of the service, as well as proposes standardized data mining service guarantee from two aspects: after-sales service and operation supervision. A customized data mining service is a kind of data mining service for users’ personalized needs. And the intelligent data mining service guarantee is proposed from two aspects of multicase experience integration and group intelligence. In the empirical research part, the big data alliance in Big Data Industry Alliance, which provides data mining service as the main business, is selected as the research object, and the data mining service model of the big data alliance proposed in this article is applied to the actual alliance to verify the scientific and rationality of the data mining service model and improve the data mining service model management system.
Analysis and Research of the High-Cycle Fatigue Fracture Mode Based on Stress Ratio and Residual Stress of Ti-6Al-4V
Authors: Wang Fu , Wang Jian-Jun , Li Qin-Sheng , Ren Guo-Zhu , Zhang Xin-Jian , Zhang Shu-quan
Published: January 2022

The content of titanium is about 0.63% in the earth’s crust, and it ranks 10th among all elements. The content of titanium is next to the metal elements of aluminum, iron and magnesium, iron, and magnesium; titanium alloys have low density, high specific strength (the ratio of tensile strength to density), wide working range (−253°C–600°C), and excellent corrosion resistance melting point; the chemical activity of titanium alloy is very high, and it easily reacts with hydrogen, oxygen, and nitrogen, so it is difficult to be smelted and processed, and the processing cost is high. Titanium alloys also have poor thermal conductivity (only 1/5 of iron and 1/15 of aluminum), small deformation coefficient, large friction coefficient, and other characteristics. They are widely used in aircraft fuselage, gas turbine, petrochemical, automotive industry, medical, and other fields for important parts.
Automobile Industry under China’s Carbon Peaking and Carbon Neutrality Goals: Challenges, Opportunities, and Coping Strategies
Authors: Zhao Fuquan , Liu Xinglong , Zhang Haoyi , Liu Zongwei
Published: January 2022

China has already committed to peaking carbon dioxide emissions by 2030 and achieving carbon neutrality by 2060 (referred to as the 30·60 Target), which has brought both daunting challenges and great opportunities to the automobile industry in China. However, there is still a lack of comprehensive and in-depth studies on the challenges, paths, and strategies for reducing carbon emissions to fulfill the 30·60 Target in automobile industries. Therefore, this paper proposes low-carbon development strategies for China’s automobile industry. This study’s method is to integrate the results from different literature to summarize the status, challenges, opportunities, and refine the coping strategies for carbon emission of the automobile industry. The results indicated that the paths for achieving the 30·60 Target include joint carbon emission reduction by upstream and downstream enterprises inside the industry. It also needs cross-industry and cross-sector coordinated decarbonization outside the industry. Meanwhile, the low-carbon policy and regulation system should be established to provide a direct driving force and fundamental guarantee for the low-carbon development of China’s automobile industry.
[Retracted] Identification of Molecular Biomarkers and Key Pathways for Esophageal Carcinoma (EsC): A Bioinformatics Approach
Authors: Islam Md. Rakibul , Alam Mohammad Khursheed , Paul Bikash Kumar , Koundal Deepika , Zaguia Atef , Ahmed Kawsar
Published: January 2022

Esophageal carcinoma (EsC) is a member of the cancer group that occurs in the esophagus; globally, it is known as one of the fatal malignancies. In this study, we used gene expression analysis to identify molecular biomarkers to propose therapeutic targets for the development of novel drugs. We consider EsC associated four different microarray datasets from the gene expression omnibus database. Statistical analysis is performed using R language and identified a total of 1083 differentially expressed genes (DEGs) in which 380 are overexpressed and 703 are underexpressed. The functional study is performed with the identified DEGs to screen significant Gene Ontology (GO) terms and associated pathways using the Database for Annotation, Visualization, and Integrated Discovery repository (DAVID). The analysis revealed that the overexpressed DEGs are principally connected with the protein export, axon guidance pathway, and the downexpressed DEGs are principally connected with the L13a‐mediated translational silencing of ceruloplasmin expression, formation of a pool of free 40S subunits pathway. The STRING database used to collect protein‐protein interaction (PPI) network information and visualize it with the Cytoscape software. We found 10 hub genes from the PPI network considering three methods in which the interleukin 6 (IL6) gene is the top in all methods. From the PPI, we found that identified clusters are associated with the complex I biogenesis, ubiquitination and proteasome degradation, signaling by interleukins, and Notch‐HLH transcription pathway. The identified biomarkers and pathways may play an important role in the future for developing drugs for the EsC.
A Family of Bayesian Estimators for the Two-Parametric Burr Type II Distribution
Authors: Alshenawy R. , Feroze Navid , Al-Alwan Ali , Saleem Mahreen , Islam Sahidul
Published: January 2022

This study discusses the posterior estimation for the parameters of the Burr type II distribution (BIID). The informative and noninformative priors along with different loss functions have also been assumed for the posterior estimation. The applicability of the proposed distribution has also been discussed. The modeling capability of the proposed model has been compared with seven classes of the lifetime distributions using real data. The generalizations of Weibull, exponential, Rayleigh, gamma, log normal, Pareto, Maxwell, Levy, Laplace, inverse gamma, Gompertz, chi-square, inverse chi-square, half normal, and log-logistic distributions have been considered for the comparison. The comparison has been made based on different goodness-of-fit criteria, such as Akaike information criteria (AIC), Bayesian information criteria (BIC), and Kolmogorov-Smirnov (KS) test. Based on the results from the study, it can be suggested that the BIID can efficiently replace commonly used lifetime distributions and their modifications. The results under this model were comparable with different conventional/modified distributions having up to six parameters.
Microstructural Dynamics of the Myocardium: Orientation of the Muscle Fibers and Occurrence of Cardiomyopathies
Authors: Djoumessi René Thierry , Pelap François Beceau
Published: January 2022

This paper considers the Holzapfel–Ogden (HO) model to examine the behavior of the left ventricle myocardium. At the tissue level, we analyze the contributions of the orientation angle of muscle fibers (MFs) and investigate their effects on the occurrence of certain cardiomyopathies and congenital diseases at the organ level. Knowing the importance of myocardial microstructure on cardiac function, we vary the angle between the direction of collagen sheets and MFs in all layers of the myocardium (from epicardium to endocardium) to model the effects of tilted MFs. Based on the HO model in which the directions of the fibers are orthogonal and using the strain energy of HO, we construct a tensile-compression test and simulate the dynamics of a cubic sample. We recover the authors’ results exhibiting the existence of residual stresses in various directions. Then, we modify the energy of HO slightly to assess the impact of the same stress states on the system with tilted MFs. A numerical tensile-compression test performed on this new cubic sample shows that, in certain directions, the heart tissue is more resistant to shear deformations in some planes than in others. Moreover, it appears that the residual stress is smaller as the angle of orientation of the MFs is small. Furthermore, we observe that the residual stress is greater in the new model compared to the normal HO model. This could affect the heart muscle at the organ level leading to hypertrophied/dilated cardiomyopathy.
Video Content Analysis of Human Sports under Engineering Management Incorporating High-Level Semantic Recognition Models
Authors: Hui Ruan
Published: January 2022

In this paper, a high-level semantic recognition model is used to parse the video content of human sports under engineering management, and the stream shape of the previous layer is embedded in the convolutional operation of the next layer, so that each layer of the convolutional neural network can effectively maintain the stream structure of the previous layer, thus obtaining a video image feature representation that can reflect the image nearest neighbor relationship and association features. The method is applied to image classification, and the experimental results show that the method can extract image features more effectively, thus improving the accuracy of feature classification. Since fine-grained actions usually share a very high similarity in phenotypes and motion patterns, with only minor differences in local regions, inspired by the human visual system, this paper proposes integrating visual attention mechanisms into the fine-grained action feature extraction process to extract features for cues. Taking the problem as the guide, we formulate the athlete’s tacit knowledge management strategy and select the distinctive freestyle aerial skills national team as the object of empirical analysis, compose a more scientific and organization-specific tacit knowledge management program, exert influence on the members in the implementation, and revise to form a tacit knowledge management implementation program with certain promotion value. Group behavior can be identified by analyzing the behavior of individuals and the interaction information between individuals. Individual interactions in a group can be represented by individual representations, and the relationship between individual behaviors can be analyzed by modeling the relationship between individual representations. The performance improvement of the method on mismatched datasets is comparable between the long-short time network based on temporal information and the language recognition method with high-level semantic embedding vectors, with the two methods improving about 12.6% and 23.0%, respectively, compared with the method using the original model and with the i-vector baseline system based on the support vector machine classification method with radial basis functions, with performance improvements about 10.10% and 10.88%, respectively.
Influence of Network Multimedia Nutritional Supplements on Basketball Exercise Fatigue Based on Embedded Microprocessor
Authors: Chen Qiao , Liu Shihong
Published: January 2022

Sports can cause the consumption of energy materials in the body. The rational use of nutritional supplements can maintain the homeostasis of the organism, which plays a very important role in improving the competitive performance of sports athletes. The purpose of this study is to explore the effect of nutritional supplements on basketball sports fatigue. The method of this study is as follows: first of all, 15 basketball players in our city were selected as the experimental objects, and they were randomly divided into the experimental group and the control group. The members of the experimental group took nutrients. After the training, 6 days a week, 3 hours in the morning and 3 hours in the afternoon, and the rest was adjusted on Sunday. Before training, four weeks and eight weeks of training, the blood routine indexes and body functions of athletes were tested. The results showed that the number of red blood cells, hemoglobin concentration, and average hemoglobin concentration of ligustilide supplement of the athletes were at the level of 0.05 after 4 weeks and 8 weeks, and the difference was significant (

P
<
0.05

). The nutritional supplements were used in sprint (3.4 s less), long-distance running (12.8 s less), and weight lifting (6.2 kg more) to a certain extent. Nutritional supplements are used as an auxiliary means of diet to supplement the amino acids, trace elements, vitamins, minerals, etc. required by the human body. The conclusion is that nutrition supplement can effectively improve the indexes of athletes’ body in about four weeks, but the effect is not obvious after a long time. This study provides a certain method for the research of nutritional supplements in the field of sports.
Fractional Model and Exact Solutions of Convection Flow of an Incompressible Viscous Fluid under the Newtonian Heating and Mass Diffusion
Authors: Sene Ndolane
Published: January 2022

In this paper, we consider a natural convection flow of an incompressible viscous fluid subject to Newtonian heating and constant mass diffusion. The proposed model has been described by the Caputo fractional operator. The used derivative is compatible with physical initial and boundaries conditions. The exact analytical solutions of the proposed model have been provided using the Laplace transform method. The obtained solutions are expressed using some special functions as the Gaussian error function, Mittag–Leffler function, Wright function, and G‐function. The influences of the order of the fractional operator, parameters used in modeling the considered fluid, Nusselt number, and Sherwood number have been analyzed and discussed. The physical interpretations of the influences of the parameters of our fluid model have been presented and analyzed as well. We use the graphical representations of the exact solutions of the model to support the findings of the paper.
Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared β-Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018)
Authors: Strazzulla Alessio , Postorino Maria Concetta , Belfeki Nabil , Iordache Laura , de Pontfarcy Astrid , Pitsch Aurelia , Leroy Pierre , Jochmans Sebastien , Monchi Mehran , Diamantis Sylvain
Published: January 2022

Introduction. The risk of extended spectrum β-lactamase (ESBL) bacterial acquisition in patients with β-lactam allergy has been poorly investigated. In a previous study conducted over a 6-year long period (2007-2012), we found that patients with declared β-lactam allergy had a higher risk of ESBL bacterial carriage at admission in intensive care unit (ICU), but they had not a higher risk of ESBL bacterial acquisition. We present the final results of the study which was eventually conducted over a 12-year long period (2007-2018). Materials and Methods. The study included all patients admitted in ICU and receiving antibiotic treatment from January 2007 to December 2018. ESBL bacterial acquisition was the main clinical outcome. Mortality in ICU, multidrug resistant bacterial carriage at admission and discharge were the secondary outcomes. Results. Overall, 3332 patients were included, 132/3332 (3.9%) were labelled β-lactam allergic, while 3200/3332 (96.1%) did not presented β-lactam allergy. No significant difference in rates of ESBL acquisition was detected (4/132, 3% vs. 78/3200, 2.4%;p=0.17). Patients with β-lactam allergy had higher rates of ESBL bacterial carriage at admission (19/132, 14.4% vs. 248/3200, 7.8%,p=0.01) and at discharge (22/132, 16.7% vs. 351/3200, 11%,p=0.04) than nonallergic patients. No differences in mortality, duration of hospitalization, and carriage of methicillin resistant Staphylococcus aureus were reported. Female gender was the only factor associated with β-lactam allergy at the multivariate analysis. Conclusions. This study confirms that patients with declared β-lactam allergy had not a higher risk of ESBL bacterial acquisition during hospitalization in ICU. However, they had a higher ESBL bacterial carriage at admission.
Numerical Simulation of Flow-Induced Vibration of Three-Dimensional Elastic Heat Exchanger Tube Bundle Based on Fluid-Structure Coupling
Authors: Ai Shiqin , Sun Chao , Liu Yuechan , Li Yuelin
Published: January 2022

The reliability of the heat exchanger tube bundle not only affects the economic efficiency of production but also relates to the normal development of production safety and health. To study the flow-induced vibration of tube bundles, a three-dimensional finite element model of heat exchange tubes and watersheds inside and outside the tubes was established to explore the flow-induced vibration characteristics of tube bundles and analyze the natural frequencies of single-span and multispan heat exchange tubes. Considering the randomness of the effective support between the tube bundle and the support plate of the heat exchanger, the natural frequency and vibration mode of the four-span tube with failure of the tube bundle support are analyzed. On this basis, the vibration caused by the two-way coupling flow between tube and tube outflow is calculated. Finally, the flow-induced vibration characteristics of the five-tube bundle with two different pitch-diameter ratios are analyzed. The calculation results show that the error between the calculated natural frequencies and the theoretical values is less than 3%, and within the allowable error range, the natural frequencies of the same order decrease with the increase of the number of support failures. The vibration frequencies of single-span and multispan tube bundles are consistent with the lift and drag frequencies, the vibration displacement curves show typical Strouhal modes, and the amplitude increases with the increase of fluid velocity. Vibration displacement curves of symmetrical spans of multispan tube bundles are similar in shape and amplitude. With the increase of tube bundle spacing, the vibration characteristics become more obvious.
Modelling the Impact of RCEP Agreement on the Economic and Trade Environment of Beijing
Authors: Liu Yuanqing , Chen Xiongying , Tian Yuan
Published: January 2022

As a national economic, political, and cultural center that ranks first in terms of openness to the outside world, the signing of the RCEP agreement has undoubtedly brought a series of opportunities and challenges to Beijing. Based on the analysis of the two main features embodied in the RCEP agreement, this paper precisely analyzes the areas where the RCEP agreement has a key impact on Beijing’s economy and trade and points out the opportunities and challenges brought by the RCEP agreement to Beijing’s economic and trade development.
Radio Network Forensic with mmWave Using the Dominant Path Algorithm
Authors: Kamboh Usman Rauf , Shahid Muhammad Rehman , Aldabbas Hamza , Rafiq Ammar , Alouffi Bader , Habib Muhammad Asif , Ullah Ubaid
Published: January 2022

For the last two decades, cybercrimes are growing on a daily basis. To track down cybercrimes and radio network crimes, digital forensic for radio networks provides foundations. The data transfer rate for the next-generation wireless networks would be much greater than today’s network in the coming years. The fifth-generation wireless systems are considering bands beyond 6 GHz. The network design of the next-generation wireless systems depends on propagation characteristics, frequency reuse, and bandwidth variation. This article declares the channel’s propagation characteristics of both line of sight (LoS) and non-LOS (NLoS) to construct and detect the path of rays coming from anomalies. The simulations were carried out to investigate the diffraction loss (DL) and frequency drop (FD). Indoor and outdoor measurements were taken with the omnidirectional circular dipole antenna with a transmitting frequency of 28 GHz and 60 GHz to compare the two bands of the 5th generation. Millimeter-wave communication comes with a higher constraint for implementing and deploying higher losses, low diffractions, and low signal penetrations for the mentioned two bands. For outdoor, a MATLAB built-in 3D ray tracing algorithm is used while for an indoor office environment, an in-house algorithmic simulator built using MATLAB is used to analyze the channel characteristics.
KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGFβ Activity
Authors: Xiao Jin-Fen , Kua Ley-Fang , Ding Ling-Wen , Sun Qiao-Yang , Myint Khine Nyein , Chia Xiu-Rong , Venkatachalam Nachiyappan , Loh Xinyi , Duex Jason E. , Neang Vanessa , Zhou Siqin , Li Ying , Yang Henry , Koeffler H. Phillip , Theodorescu Dan
Published: January 2022

KDM6A, an X chromosome-linked histone lysine demethylase, was reported to be frequently mutated in many tumor types including breast and bladder cancer. However, the functional role of KDM6A is not fully understood. Using MCF10A as a model of non-tumorigenic epithelial breast cells, we found that silencing KDM6A promoted cell migration and transformation demonstrated by the formation of tumor-like acini in three-dimensional culture. KDM6A loss reduced the sensitivity of MCF10A cells to therapeutic agents commonly used to treat patients with triple-negative breast cancer and also induced TGFβ extracellular secretion leading to suppressed expression of cytotoxic genes in normal human CD8+ T cells in vitro. Interestingly, when cells were treated with TGFβ, de novo synthesis of KDM6A protein was suppressed while TGFB1 transcription was enhanced, indicating a TGFβ/KDM6A-negative regulatory axis. Furthermore, both KDM6A deficiency and TGFβ treatment promoted disorganized acinar structures in three-dimensional culture, as well as transcriptional profiles associated with epithelial-to-mesenchymal transition and metastasis, suggesting KDM6A depletion and TGFβ drive tumor progression.

Implications:

Our study provides the preclinical rationale for evaluating KDM6A and TGFβ in breast tumor samples as predictors for response to chemo and immunotherapy, informing personalized therapy based on these findings.
Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation
Authors: Vanhaesebroeck Bart , Burke John E. , Madsen Ralitsa R.
Published: January 2022

PIK3CA, which encodes the p110α catalytic subunit of PI3Kα, is one of the most frequently genetically activated kinases in solid tumors. In this issue of Cancer Discovery, Song and colleagues report that the related PI3Kα inhibitors taselisib and inavolisib trigger receptor tyrosine kinase (RTK)–dependent degradation of the mutant p110α protein in breast cancer cells that are positive for HER2 RTK, limiting feedback-mediated drug resistance and potentially widening the therapeutic index of PI3Kα inhibition.

See related article by Song et al., p. 204.
Patritumab Deruxtecan: Paving the Way for EGFR-TKI–Resistant NSCLC
Authors: Lim Sun Min , Kim Chang Gon , Lee Jii Bum , Cho Byoung Chul
Published: January 2022

HER3 is ubiquitously expressed in EGFR-mutant non–small cell lung cancer (NSCLC) irrespective of resistant mechanisms to EGFR tyrosine kinase inhibitors, thus garnering attention as a valuable therapeutic target. In this issue of Cancer Discovery, Jänne and colleagues highlight early clinical data supporting patritumab deruxtecan as a potentially appreciable agent for previously treated EGFR-mutant NSCLC.

See related article by Jänne et al., p. 74.
Azacitidine to Consolidate and Deepen the Therapeutic Response Achieved by Intensive Induction Treatment in a Young Patient Affected by NPM1mut-AML Who Has Become Ineligible for High-Dose Consolidation
Authors: Cenfra Natalia , Lapietra Gianfranco , Perrone Salvatore , Voso Maria Teresa , Divona Mariadomenica , Mecarocci Sergio , La Barbera Elettra Ortu , Cimino Giuseppe
Published: January 2022

Acute myeloid leukemia (AML) is the most common leukemia in adults. In spite of the most recent discoveries about the molecular landscape of this disease, the treatment of elderly and unfit young patients continues to be a great challenge. The hypomethylating agents (HMA) still represent an effective therapeutic option for these categories, especially for the low-risk subgroups. We report the case of a young patient with NPM1mut-AML who underwent a first cycle of intensive induction treatment, achieving a complete remission, but suffered from a serious life-threatening neurologic toxicity. Due to the ineligibility to further lines of intensive chemotherapy, we decided to consolidate the response with azacitidine, administered according to the regular schedule. The minimal residual disease (MRD), monitored through the NPM1 mutation at diagnosis, progressively decreased and became undetectable after 36 cycles of hypomethylating therapy. After 1 year from discontinuation of azacitidine, MRD remains undetectable. Therefore, HMA might still represent a feasible and effective option for patients with low-risk AML, especially when the standard chemotherapy is not indicated, or as maintenance therapy in nontransplantable patients.
Identification of Serum Biomarkers in Patients with Alzheimer’s Disease by 2D-DIGE Proteomics
Authors: Zhang Xuezhi , Yu Wenwen , Cao Xuelei , Wang Yongbin , Zhu Chao , Guan Jialiang
Published: January 2022

Aim: The aim of this study is to identify potential serum biomarkers of Alzheimer’s disease (AD) for early diagnosis and to evaluate these markers on a large cohort. Methods: We performed two-dimensional difference gel electrophoresis to compare the serum of AD patients and normal controls. Western blot or enzyme-linked immunosorbent assay (ELISA) was used to identify the expression levels of proteins. Results: In this study, a total of 13 differentially expressed proteins were identified. Among them, 2 proteins (inter-alpha-trypsin inhibitor heavy chain H4 [ITI-H4], Apolipoprotein A-IV) were validated by Western blot and 4 proteins (Cofilin 2, Tetranectin, Zinc-alpha-2-glycoprotein [AZGP1], Alpha-1-microglobulin/bikunin precursor [AMBP]) were validated by ELISA, respectively. Western blot results showed that the full size of the ITI-H4 protein was increased, while a fragment of ITI-H4 was decreased in AD patients. In contrast, 1 fragment of Apo A-IV was mainly found in control group and rare to be detected in AD patients. On the other hand, ELISA results showed that Cofilin 2, Tetranectin, AZGP1, and AMBP were significantly increased in AD patients, and Cofilin 2 is strongly correlated with the Mini-Mental State Examination scores of the AD patients. Serum Cofilin 2 was unchanged in Parkinson disease patients as compared to the control group, indicating a specific correlation of serum Cofilin 2 with AD. Moreover, Cofilin 2 was increased in both the serum and brain tissue in the APP/PS1 transgenic mice. Conclusion: Our study identified several potential serum biomarkers of AD, including: ITI-H4, ApoA-IV, Cofilin 2, Tetranectin, AZGP1, and AMBP. Cofilin 2 was upregulated in different AD animal models and might play important roles in AD pathology.
Hydrogen: A Novel Treatment Strategy in Kidney Disease
Authors: Wang Bo , Li Zhuoshu , Mao Longfei , Zhao Mingyi , Yang Bingchang , Tao Xiaowu , Li Yuxiang , Yin Guangming
Published: January 2022

Background: Hydrogen is a chemical substance that has yet to be widely used in medicine. However, recent evidence indicates that hydrogen has multi-faceted pharmacological effects such as antioxidant, anti-inflammatory, and antiapoptotic properties. An increased number of studies are being conducted on the application of hydrogen in various diseases, especially those affecting the renal system. Summary: Hydrogen can be inhaled, as a gas or liquid, and can be administered orally, intravenously, or locally. Hydrogen can rapidly enter suborganelles such as mitochondria and nucleus by simple diffusion, producing reactive oxygen species (ROS) and triggering DNA damage. Hydrogen can selectively scavenge hydroxyl radical (•OH) and peroxynitrite (ONOO−), but not other reactive oxygen radicals with physiological functions, such as peroxyanion (O2−) and hydrogen peroxide (H2O2). Although the regulatory effect of hydrogen on the signal transduction pathway has been confirmed, the specific mechanism of its influence on signal molecules remains unknown. Although many studies have investigated the therapeutic and preventive effects of H2 in cellular and animal experiments, clinical trials are few and still far behind. As a result, more clinical trials are required to investigate the role of hydrogen in kidney disease, as well as the effect of its dose, timing, and form on the overall efficacy. Large-scale randomized controlled clinical trials will be required before hydrogen can be used to treat renal illnesses. Key Messages: This article reviews the mechanisms of hydrogen in the treatment of renal disease and explores the possibilities of its use in clinical practice.
Cleft Lip Palate in a Patient with 5q14.3 Deletion Syndrome: A Possible Unreported Feature?
Authors: Fernández Hernández Liliana , Alcántara Ortigoza Miguel A. , Ramos Angeles Sandra E. , González-del Angel Ariadna
Published: January 2022

5q14.3 deletion syndrome (MIM#613443) is an uncommon but well-known syndrome characterized by intellectual disability, epilepsy, hypotonia, brain malformations, and facial dysmorphism. Most patients with this syndrome have lost one copy of the MEF2C gene (MIM*600662), whose haploinsufficiency is considered to be responsible for the distinctive phenotype. To date, nearly 40 cases have been reported; the deletion size and clinical spectrum are variable, and at least 6 cases without MEF2C involvement have been documented. We herein report the clinical and cytogenomic findings of an 11-year-old girl who has a 5q14.3q21.1 de novo deletion that does not involve MEF2C but shares the clinical features described in other reported patients. Moreover, she additionally presents with bilateral cleft-lip palate (CLP), which has not been previously reported as a feature of the syndrome. The most frequent syndromic forms of CLP were ruled out in our patient mainly by clinical examination, and Sanger sequencing was performed to discard the presence of a TBX22 gene (MIM*300307) defect. Our report suggests CLP as a possible unreported feature and redefines the critical phenotypic regions of 5q14.3 deletion syndrome.
Deciphering the Mechanism of Glyphosate Resistance in Amaranthus palmeri by Cytogenomics
Authors: Koo Dal-Hoe , Sathishraj Rajendran , Friebe Bernd , Gill Bikram S.
Published: January 2022

In agriculture, various chemicals are used to control the weeds. Out of which, glyphosate is an important herbicide invariably used in the cultivation of glyphosate-resistant crops to control weeds. Overuse of glyphosate results in the evolution of glyphosate-resistant weeds. Evolution of glyphosate resistance (GR) in Amaranthus palmeri (AP) is a serious concern in the USA. Investigation of the mechanism of GR in AP identified different resistance mechanisms of which 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene amplification is predominant. Molecular analysis of GR AP identified the presence of a 5- to >160-fold increase in copies of the EPSPS gene than in a glyphosate-susceptible (GS) population. This increased copy number of the EPSPS gene increased the genome size ranging from 3.5 to 11.8%, depending on the copy number compared to the genome size of GS AP. FISH analysis using a 399-kb EPSPS cassette derived from bacterial artificial chromosomes (BACs) as probes identified that amplified EPSPS copies in GR AP exist in extrachromosomal circular DNA (eccDNA) in addition to the native copy in the chromosome. The EPSPS gene-containing eccDNA having a size of ∼400 kb is termed EPSPS-eccDNA and showed somatic mosacism in size and copy number. EPSPS-eccDNA has a genetic mechanism to tether randomly to mitotic or meiotic chromosomes during cell division or gamete formation and is inherited to daughter cells or progeny generating copy number variation. These eccDNAs are stable genetic elements that can replicate and exist independently. The genomic characterization of the EPSPS locus, along with the flanking regions, identified the presence of a complex array of repeats and mobile genetic elements. The cytogenomics approach in understanding the biology of EPSPS-eccDNA sheds light on various characteristics of EPSPS-eccDNA that favor GR in AP.
Use of Rituximab as an Off-Label Medication in Glomerular Diseases: Clinical Perspective
Authors: AlSahow Ali , Al-Muhaiteeb Abdullah , Nawar Hani , AlHelal Bassam , AlYousef Anas , Abdallah Emad , AbuShall Ahmad , Elmekawi Sameh , Meshal Basem , AlQallaf Ahmed , AlRajab Heba
Published: January 2022

Objectives: The aim of this study was to review the use rituximab (RTX) and outcomes in immune-mediated glomerular diseases (glomerulonephritis [GN]) and to compare it to the established literature. Methods: Adult GN patients who received RTX between January 2014 and January 2018 in three public hospitals were reviewed. Membranous nephropathy (MN) and minimal change disease (MCD) were considered diseases with the literature supporting RTX use. Lupus nephritis (LN), primary focal segmental glomerulosclerosis (1o FSGS), IgA nephropathy, IgG4-related disease (IgG4-RD), and C3GN had insufficient literature support for RTX use. Clinical remission was assessed 6 months after receiving RTX. Results: A total of 61 cases were analyzed. RTX was an add-on therapy in 87%. The remission rate was 95% in the MCD and MN versus 56% in the off-label group (p = 0.002). LN patients had a mean initial estimated glomerular filtration rate (eGFR) of 69 mL/min. All class III LN achieved remission, and 11 of 21 class IV achieved remission. The mean initial eGFR for 1o FSGS was 33 mL/min, and it did not improve, and only 2 of 5 had partial resolution of proteinuria. Proteinuria improved in 3 of 5 IgG4-RD cases with eGFR stabilization but failed to improve in C3GN cases with eGFR deterioration. Vasculitis cases (6 ANCA-associated vasculitis and 2 IgA vasculitis) were analyzed separately. Remission was achieved in only 2 ANCA-associated vasculitis cases, and none in IgA vasculitis cases. Conclusions: Our data support the use of RTX in resistant MCD and MN. RTX showed success in LN and IgG4-RD but not FSGS or C3GN. The small number of cases of vasculitis does not allow drawing a conclusion on RTX effectiveness.
A Reevaluation of the 1990 “Minnesota Study of Twins Reared Apart” IQ Study
Authors: Joseph Jay
Published: January 2022

In 1990, Thomas J. Bouchard Jr. and colleagues published the widely cited 1990 “Minnesota Study of Twins Reared Apart” (MISTRA) Science IQ study. To arrive at the conclusion that “IQ is strongly affected by genetic factors,” Bouchard and colleagues omitted their control group reared-apart dizygotic twin (DZA) IQ score correlations. Near-full-sample correlations published after the study’s 2000 end point show that the reared-apart monozygotic twin (MZA) and DZA group IQ correlations did not differ at a statistically significant level, suggesting that the study failed the first step in determining that IQ scores are influenced by heredity. After bypassing the model-fitting technique they used in most non-IQ MISTRA studies, the researchers assumed that the MZA group IQ score correlation alone “directly estimates heritability.” This method was based on unsupported assumptions by the researchers, and they largely overlooked the confounding influence of cohort effects. Bouchard and colleagues then decided to count most environmental influences they did recognize as genetic influences. I conclude that the MISTRA IQ study failed to discover genetic influences on IQ scores and cognitive ability across the studied population, and that the study should be evaluated in the context of psychology’s replication problem.
Antecedentes, contexto y problemáticas de los fideicomisos en México
Authors: Cruz Bermea Alejandro
Published: January 2022

En México, el fideicomiso público como figura jurídica de larga tradición es actualmente objeto de controversias políticas vinculadas a su funcionamiento, principalmente por la falta de transparencia y de rendición de cuentas, corrupción, antinomias, desempeño limitado, extinción institucional, entre otras problemáticas de interés para las ciencias sociales y la teoría organizacional. El artículo está orientado a reflexionar sobre los fideicomisos en México, considerando sus antecedentes, problemáticas y contexto, con atención particular al Fideicomiso de Fomento Minero (FIFOMI), institución de la banca de fomento, y unidad empírica de este estudio etnográfico en proceso sobre su cultura, estructura y procesos organizacionales, en un momento político donde se cuestiona su permanencia tras decretarse la eliminación de 109 fideicomisos en materia de derechos humanos, ciencia, energías renovables y desastres naturales. Los resultados preliminares aquí expuestos son parte de un trabajo etnográfico en curso.      
 La exposición está orientada a reflexionar en torno a los antecedentes, problemáticas y contexto de los fideicomisos en México, con atención particular al Fideicomiso de Fomento Minero (FIFOMI), institución de la banca de fomento y unidad empírica de un estudio etnográfico en proceso sobre su cultura, estructura y procesos organizacionales, en un contexto político donde se cuestiona la opacidad financiera y falta de transparencia de los fideicomisos y se ha decretado la eliminación de 109 de ellos en materia de derechos humanos, ciencia, energías renovables y desastres naturales.
descolonização literária latino-americana segundo Gutiérrez
Authors: Mendes Daniel
Published: January 2022

Este artigo fundamenta a tese da descolonização literária latino-americana por meio de uma proposta de releitura anti-exótica sobre a obra Trilogía sucia de La Habana (1998) do escritor cubano Pedro Juan Gutiérrez (1950-  ). A releitura foi realizada a partir da percepção da obra como uma experiência da literatura na América Latina que deve ser compreendida a partir dos movimentos descoloniais do seu autor, do propósito de não aderir a modelos hegemônicos do campo literário e de criar caminhos condizentes com o seu lugar de expressão. Tal movimento foi fundamentado a partir de uma retomada da teoria crítica literária de Silviano Santiago (1936 -  ) sobre o entre-lugar do discurso latino-americano, que nos serviu como fio condutor analítico. Nesse trajeto, estabelecemos diálogos com outros estudos sobre tradução cultural e literária neste continente, especialmente quanto a abordagens teóricas da antropofagia, heterogeneidade, transculturação narrativa, assim como com os estudos decoloniais latino-americanos, dentre outros estudos pertinentes, no intuito de evidenciarmos na Trilogía a tese da descolonização literária proposta por Gutiérrez. Assim, subvertemos o exotismo imposto pela crítica euro-estadunidense a esta obra apontando caminhos plausíveis para abordagens críticas sobre a mesma
Higher Plasma Aldosterone Concentrations Are Associated With Elevated Risk of Aortic Dissection and Aneurysm: a Case-Control Study
Authors: Zhu Qing , Heizhati Mulalibieke , Lin Mengyue , Wang Menghui , Yao Xiaoguang , Gan Lin , Luo Qin , Zhang Weiwei , Hong Jing , Yue Na , Li Nanfang
Published: January 2022

Background:

Animal models demonstrate circulating aldosterone leads to aortic dissection and aneurysm, whereas data from humans are lacking. Therefore, we aimed to examine the associations of plasma aldosterone concentrations (PAC) with aortic dissection and aneurysm.

Methods:

We identified patients with aortic dissection and aneurysm with assessed PAC before disease onset from hospital-based electronic database and set as case group. Simultaneously, age and gender-matched cohort with PAC measurement whereas without aortic dissection and aneurysm were selected as control group using ratio of 1:4. Multi-variable logistic regression analysis was used to assess the relationship of PAC with aortic dissection and aneurysm.

Results:

Totally, 133 cases and 531 controls (all hypertensive) were enrolled between 2004 and 2021, with 77.9% men, mean age of 55.5 years and PAC of 13.9 ng/dL. Case group showed significantly higher PAC(14.51 versus 13.65 ng/dL,
P
=0.012) than did control group. In logistic regression analysis, higher PAC exhibited 1.68-fold higher odds (95% CI, 1.14–2.48,
P
=0.008) for presence of aortic dissection and aneurysm, significant in adjusted model (odds ratio, 1.69 [95% CI, 1.11–2.57],
P
=0.015). In stratified analysis, the association between the two was observed in women of all ages and in men with coronary artery disease. Sensitivity analysis by excluding those under interfering agents at PAC measurement and those with primary aldosteronism did not change the relationship of the two.

Conclusions:

Higher PAC is associated with the increased odd for aortic dissection and aneurysm in patients with hypertension, even in the absence of primary aldosteronism, implying that PAC might be a target for prevention.
NeuMapper: A scalable computational framework for multiscale exploration of the brain’s dynamical organization
Authors: Geniesse Caleb , Chowdhury Samir , Saggar Manish
Published: January 2022

For better translational outcomes, researchers and clinicians alike demand novel tools to distill complex neuroimaging data into simple yet behaviorally relevant representations at the single-participant level. Recently, the Mapper approach from topological data analysis (TDA) has been successfully applied on noninvasive human neuroimaging data to characterize the entire dynamical landscape of whole-brain configurations at the individual level without requiring any spatiotemporal averaging at the outset. Despite promising results, initial applications of Mapper to neuroimaging data were constrained by (1) the need for dimensionality reduction and (2) lack of a biologically grounded heuristic for efficiently exploring the vast parameter space. Here, we present a novel computational framework for Mapper—designed specifically for neuroimaging data—that removes limitations and reduces computational costs associated with dimensionality reduction and parameter exploration. We also introduce new meta-analytic approaches to better anchor Mapper-generated representations to neuroanatomy and behavior. Our new NeuMapper framework was developed and validated using multiple fMRI datasets where participants engaged in continuous multitask experiments that mimic “ongoing” cognition. Looking forward, we hope our framework will help researchers push the boundaries of psychiatric neuroimaging toward generating insights at the single-participant level across consortium-size datasets.