bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of an Intelligent Virtualization Platform Key Metrics Monitoring System: Collaborative Implementation with Self-Training and Bagging Algorithm
Authors: Wu Ruey-Chyi
Published: January 2024

In recent years, virtualization platforms have not only been used to integrate data from traditional application systems but have also actively collected Internet of Things (IoT) data from various network transmissions. To address the challenges of real-time monitoring for key metrics on virtualization platforms, this study proposes an optimal machine learning training model that combines semi-supervised Self-Training algorithms with supervised ensemble algorithms. In the application of semi-supervised training learning algorithms, this study utilizes a Self-Training learning algorithm to label a large number of unlabeled virtual machine operational states with a small amount of labeled data, laying the foundation for subsequent model construction. Subsequently, an ensemble learning classification algorithm is introduced to further validate and identify learning models suitable for generalization. Empirical evaluations show that the RandomForest algorithm serves as the optimal base estimator for Self-Training, while the Bagging algorithm is the optimal choice for ensemble learning. The synergy of these two achieves an accuracy exceeding 99%, enabling the model to accurately differentiate between various operational states such as normal operation, resource insufficiency, and faults. Finally, the integrated training model is deployed to a dashboard, displaying the real-time operational status of virtual machines through different colored lights. Simultaneously, operational status information is communicated to stakeholders through various media, further improving coordination, decision-making, and resource allocation issues on the virtualization platform. This study provides an efficient and feasible solution for monitoring and managing virtualization platforms.
On the Specificities of the Arion Mosaic in the Villa del Casale (Piazza Armerina): Contribution to the Study of Arion Representations in Ancient Art
Authors: Gavrilović Anđela
Published: January 2024

The paper deals with the representation of Arion on the monumental floor mosaic in one of the most representative rooms of the Roman Villa del Casale in Sicily, dating from the beginning of the 4th century (fig. 1, 2). It is special in many respects. It is the most monumental and magnificent representation of Arion in ancient art. Arion is depicted in the central part of а complex mosaic consisting of many scenes, figures and motifs. He is sitting on a dolphin and playing music on his instrument. The dolphin motif in this scene is unique and not examined in the literature, leaving much room for research. To our knowledge, it is a unique example of a dolphin ridden by Arion, shown hunting its prey, which is certainly not a coincidence or a descriptive detail of the artist, but a reflection of his knowledge and the clear intention of the patrons of the mosaic. On the contrary, this detail subtly explains the meaning of the entire mosaic illustrating the story of Arion and the reasons for his appearance. It suggests that the owners of the villa either belonged to the highest Roman aristocracy of their time, or perhaps were even related to the imperial family. By examining the history of the specific dolphin motif it is shown that this detail bears  the symbolism of victory, thus, corresponding to the meaning of the Arion mosaic and other mosaics in Villa del Casale.
Infrastructure and Spatial Transformation of Mrzla Vodica Village in Croatia
Authors: Jarec Morana
Published: January 2024

Infrastructure projects, encompassing the construction of roads, railways, power facilities, and other structures, have a tangible impact on the physical landscape. When implemented within or through a settlement, these projects also influence cultural and social aspects of life. Despite their intention to enhance citizens' well-being as part of modernization endeavours, infrastructure initiatives often produce uneven effects on different social groups. This study focuses on the transformative processes that unfolded in the village of Mrzla Vodica, located in Gorski Kotar, Croatia, following the construction of a road in the early 19th century and a dam in the mid-20th century, up to the present day. Employing a classic ethnographic approach and a literature review, this research aims to demonstrate how infrastructure can generate both prosperity and significant disruptions to space, potentially leading to the decline or even disappearance of a community. By shedding light on the inequality produced by infrastructural development, this study contributes to a deeper understanding of modernization processes in rural area.
Profile and pattern of histology specimen of thyroidectomy patients operated in Mankweng hospital, Limpopo province, South Africa
Authors: Bhuiyan Mirza M. Z. U.
Published: January 2024

Object of study: To evaluate the histopathologic pattern of the thyroidectomy specimen in patients with goitre who underwent thyroidectomy operation at Mankweng Hospital and to review the profile of thyroid disease in relation to the age, gender & Distribution of thyroid disease which are referred to Mankweng hospital from the districts of Limpopo Province.

The problem to be solved: The demographic profile of thyroidectomy patients in this hospital is identified. Hence outreach program can be initiated according to demographic profile.

Main scientific results: Total of 62 patients analyzed: Male 2, female 60. Age range 15-70: District: Capricorn 23, Sekhukhune 33, Mopani 6. Histology: 62: Multinodular goitre 47, Papillary carcinoma 5: Hurtle cell carcinoma 3, colloid goitre 2, Diffuse colloid goitre 1, Cavernous haemangioma 1, follicular neoplasm 1, Hashimoto`s Thyroiditis 1, benign thyroid parenchyma with cyst 1

The area of practical use of research results: General surgery department in Regional & Tertiary hospital

An innovative technological product: Patient demographic profile for health outreach program.

Scope of application of an innovative technological product: General surgery department.
Bioengineering research on sesame anti-alimentary factors inactivation for confectionery industry
Authors: Tytarenko Mykhailo , Krychkovska Lidiia , Masalitin Oleksii , Varankin Volodymyr , Stankevych Serhii , Belinska Anna , Zabrodina Inna , Horiainova Viktoriia , Zhukova Liubov , Haliasnyi Ivan
Published: January 2024

The object of research. The process of inactivation of inhibitors of proteolytic enzymes of sesame seeds for use in the confectionery industry.
Investigated problem. The use of sesame seeds in the confectionery industry is very popular, as it adds a unique taste and texture to products. However, inhibitors of seed proteolytic enzymes can limit the absorption of nutrients such as proteins. This can be a problem in terms of nutritional value and efficient use of sesame seeds in the food industry. Inactivation of inhibitors of proteolytic enzymes in sesame seeds will contribute to the stability and uniformity of the quality of raw materials, which is an important aspect in the confectionery industry. This allows enterprises to ensure high sustainable quality of products containing sesame seeds and competitive advantages of such products.
The main scientific results. The features of the inactivation of anti-alimentary factors of sesame were studied, namely the influence of the initial humidity and the time of treatment with ultra high frequency (UHF) radiation on the inactivation degree of inhibitors of proteolytic enzymes of the seeds. Rational conditions for pre-treatment of sesame seeds for inactivation of anti-alimentary factors were established: moisture to 10–13 %, treatment time with UHF radiation 220–240 s. The peculiarities of the use of crushed sesame seeds with an inactivated anti-alimentary complex in the technology of high-nutrition chocolate pastes were studied. Organoleptic evaluation of test samples with different content of sesame seeds was carried out, during which the products were evaluated according to their appearance, uniformity, plasticity, color, taste and aroma. The effect of the content of crushed sesame seeds with an inactivated anti-alimentary complex on the consumer properties of chocolate pastes was determined.
The area of practical use of research results. Taking into account the results of the research can contribute not only to the improvement of technological processes in confectionery production, but also to the development of new products that meet the modern requirements of consumers.
Innovative technological product. As a result of research, an innovative food product was created, which is an innovative approach to the use of sesame seeds in the technology of chocolate pastes with increased nutritional value.
Scope of the innovative technological product. The developed innovative technological product can be implemented in food technology. In particular, the use of sesame seeds with an inactivated anti-alimentary complex in the production of chocolate pastes should become an additional advantage for manufacturers in the market, especially in the context of increased demand for health food products.
Study of the adsorption ability of natural components and their influence on product quality
Authors: Tlevlessova Dinara , Alimardanova Mariam , Bakiyeva Venera , Altayeva Balgyn
Published: January 2024

Object of research: The object of this research is the process of integrating enterosorbents, such as rice bran, pear pomace extracts, activated charcoal from rice bran, and pumpkin peel powder, into yogurt with the aim of enhancing the body's ability to eliminate heavy metals.

Investigated problem: The main problem addressed in this research is not only identifying the prospects of integrating enterosorbents into yogurt but also developing methods and approaches for the implementation of this process. Various techniques for optimal incorporation of enterosorbents are considered to create functional products that contribute to detoxifying the body.

The main scientific results: Identification of the potential and methodology for incorporating enterosorbents into yoghurt to enhance the body's ability to eliminate heavy metals.

Exploring the prospects and various methods of incorporating enterosorbents, opening up opportunities for the development of functional products that promote detoxification. Evaluating the potential use of rice husk, dried pear squeeze powder, activated charcoal and pumpkin peel powder as natural enterosorbents. These results demonstrate the significance of the study in addressing health and environmental issues, emphasizing the potential of natural ingredients to create functional and environmentally friendly products.

Practical use of research results: The practical application of the research results lies in the field of food innovations. They provide a response to current challenges related to the level of heavy metals in the environment. The practical domain includes the development of functional products promoting detoxification using natural components.

Innovative technological product: The innovative technological product proposed as a result of the research is a novel method for producing yogurts with integrated enterosorbents. This approach offers an opportunity to enhance the removal of heavy metals from the body through innovative products.

Scope of the innovative technological product: The new technological product, specifically yogurts with enterosorbents, extends its application to clinical practice and the functional food sector. It not only contributes to health improvement but also addresses challenges of heavy metal contamination, aligning with principles of sustainable consumption.
Comparison of the efficiency of phytoremediation of soil contaminated with different types of oil products
Authors: Cherniak Larysa , Maniecki Tomasz , Tykhenko Oksana , Proskurnia Оksana , Dmytrukha Tetiana
Published: January 2024

The object of research. Effectiveness of phytoremediation of soil contaminated with different types of oil products.
Investigated problem. When studying the problem of soil contamination by oil products and when looking for ways to restore soils disturbed by the chemical effects of hydrocarbon fuels, the type of oil product is not always taken into account. And a generalization is used for this type of pollution, as pollution by oil products, which does not take into account the difference in the component composition of hydrocarbon motor fuels and their different impact on the ecological state of the soil.
The main scientific results. The research results established the dependence of the effectiveness of phytoremediation of soil contaminated with oil products on the type of oil product. The obtained data made it possible to draw a conclusion about the nature of the dependence of qualitative and quantitative indicators of the level of soil phytoremediation by a certain type of plant, depending on the hydrocarbon composition of the oil product.
The area of practical use of research results. The results of the research will be used in practice when choosing the type of plants to restore the quality of soil contaminated with a certain type of oil product.
Innovative technological product. The results of the study created the basis for the development of a scientific and methodological approach to the resolved issues of restoring the quality of soil contaminated by various types of petroleum products. What can be used by specialists in the future in the development of new technologies for the restoration of soils contaminated with petroleum products.
Scope of the innovative technological product. Research results and the proposed scientific and methodological approach concern the sphere of environmental protection and transport enterprises.
Yemek Bağlamında Kültürlerarası Etkileşim: Göç, Yemek ve Kimlik İlişkisi Üzerine Kavramsal Bir Çalışma (Interaction in the Context of Food: A Conceptual Study on the Relationship between Migration, Food, and Identity)
Authors: DURSUN Furkan , DURSUN Furkan , GÜZELLER Cem Oktay
Published: January 2024

Bu çalışma, göç, yemek ve kimlik kavramlarının birbirleriyle ilişkisini incelemektedir. Farklı akademik çalışmalara dayanarak, göçmenlerin yemek kültürünün ev sahibi toplum üzerindeki etkileri ve etkileşimleri üzerinde durulmuştur. Araştırmalar, göçmen mutfağının ev sahibi toplumun mutfak kültürüne karşı direnç gösterebileceğini, uyum sağlayabileceğini ve hatta ev sahibi toplumun tüketim tercihlerini etkileyebileceğini ortaya koymaktadır. Aynı zamanda, göçle taşınan yemek kültürünün, ev sahibi toplumun mutfak kültürüyle birleşerek yeni bir füzyon mutfağının ortaya çıkmasına olanak sağlayabileceği vurgulanmaktadır. Bu çalışmanın gerekçesi, göçmen ve ev sahibi toplumların yemek kültürleri arasındaki etkileşimleri anlayabilmektir. Bu bağlamda, bahsi geçen etkileşimlerin nasıl şekillendiği ve hangi faktörlerin bu süreci etkilediği incelenmiştir. Bu sayede, göç ve yemek arasındaki ilişkiyi daha derinlemesine kavrayarak, toplumlar arası iletişimi ve anlayışı artırma amacı güdülmektedir.
Observation of non-local impedance response in a passive electrical circuit
Authors: Zhang Xiao , Zhang Boxue , Zhao Weihong , Lee Ching Hua
Published: January 2024

In media with only short-ranged couplings and interactions, it is natural to assume that physical responses must be local. Yet, we discover that this is not necessarily true, even in a system as commonplace as an electric circuit array. This work reports the experimental observation of non-local impedance response in a designed circuit network consisting exclusively of passive elements such as resistors, inductors and capacitors (RLC). Measurements reveal that the removal of boundary connections dramatically affects the two-point impedance between certain distant nodes, even in the absence of any amplification mechanism for the voltage signal. This non-local impedance response is distinct from the reciprocal non-Hermitian skin effect, affecting only selected pairs of nodes even as the circuit Laplacian exhibits universally broken spectral bulk-boundary correspondence. Surprisingly, not only are component parasitic resistances unable to erode the non-local response, but they in fact give rise to novel loss-induced topological modes at sufficiently large system sizes, constituting a new manifestation of the critical non-Hermitian skin effect. Our findings chart a new route towards attaining non-local responses in photonic or electrical metamaterials without involving non-linear, non-local, active or amplificative elements.
Analysis and Design of Web-Based E-Commerce At CMYK.Project
Authors: Sonida Ramadhan
Published: January 2024

The research objective is to design an e-commerce website in the CMYK.PROJECT company where customers can make purchases in the company's website and the company can also provide information and serve the customers in e-commerce website. Research methods in this study, using data collection and methods of system design e-commerce. Collecting data in this thesis is done through interviews, questionnaires, and direct observation to the company. In this thesis analyzes used is the analysis of SEM-PLS and E-Commerce Strategy. Designing for the e-commerce company in this thesis using OOAD and Framework 7C. Results is in getting the results of e-commerce website for the company to sell products to customers, and customers can make purchases in the e-commerce company. The conclusion obtained is with their e-commerce website, it can shorten the sales process of the company's products to customers, and also facilitates the transaction purchase the company's products.
Analysis of Consumer Market Preferences of Electronic Products In 8 Sub-Districts of South Bogor to Predict Demand In PT. Ruma
Authors: Nindyantika Vicianti
Published: January 2024

Understanding the factors that influence preference is an opportunity for companies to understand market segments. With market segmentation, marketers can identify potential group and predict customer demand. Understanding the market segment can also make marketers develop strategies of differentiation and positioning formation on the right target market. This study aims to determine the market preference for electronic products based on psychographic segments to predict demand of member PT. RUMA. Methods of data collection using questionnaires distributed to 100 customers by using conjoint and cluster analysis.
Analysis The Impact of Service Quality, Customer Satisfaction, Customer Commitment, On Word of Mouth
Authors: Viadi Kevin
Published: January 2024

The development of an Internet service influenced by the quality of services provided and customer satisfaction that have an impact on customers who are committed to continue to subscribe to the impact to the customer to do word of mouth. The purpose of this study was to determine the effect of service quality and customer satisfaction, for customer commitment and its impact on word of mouth that is useful to get a promotion without charge on the internet located around Jakarta. The method used in this study is path analysis by distributing questionnaires and then tested for normality, validity, and reliability as evidence that the data obtained feasible to do research. Analysis of the results achieved is the influence of service quality and customer satisfaction that have an impact on customer commitment that influence word of mouth. From data processing, the quality of service and customer satisfaction affects customer commitmentt. While the quality of service, customer commitment and customer commitment influence word of mouth.
Comparação dos ganhos profissionais de egressos cotistas e não cotistas das universidades federais brasileiras
Authors: Carvalho Junior José Roberto Abreu de , Xavier Wescley Silva , Ferreira Marco Aurélio Marques
Published: January 2024

Após 10 anos da política de cotas das universidades federais, a literatura ainda carece de pesquisas sobre a inserção dos egressos cotistas e não cotistas no mercado de trabalho. Diante desse problema, o objetivo do artigo foi comparar os ganhos no mercado de trabalho entre egressos cotistas e não cotistas dos cursos de graduação das universidades federais brasileiras. Para tanto, aplicamos um questionário eletrônico, que foi respondido por uma expressiva amostra de 11.458 egressos, de 248 cursos de graduação, de todas as áreas do conhecimento, de 18 universidades federais e das cinco regiões do Brasil. Por meio do Teste de Qui-Quadrado, comparamos o status de ocupação, o motivo de não trabalhar, o setor de atuação, o tipo de cargo/emprego, a remuneração, o porte da empresa/organização e a ocupação de cargos de chefia ou de direção entre os egressos. Os resultados sugerem que egressos cotistas obtêm altas taxas de ocupação, com uma boa inserção no mercado de trabalho, trabalhando em cargos/empregos ditos mais qualificados, em empresas/organizações de grande porte e recebendo boas remunerações. Porém, os resultados sugerem que, em geral, os ganhos ocupacionais e salariais de egressos cotistas ainda são inferiores aos de egressos não cotistas. Logo, nossos resultados sugerem que a política de cotas das universidades federais é uma importante ferramenta de inclusão socioeconômica dos estudantes cotistas, justificando sua existência, mas que ela, por si só, ainda não completamente elimina a forte desigualdade social entre as famílias brasileiras, que parece afetar diferentemente os ganhos dos profissionais no mercado de trabalho.
Diversidade e inclusão nas Big Four: a abordagem dos vieses inconscientes
Authors: Silveira Maysa Lélia da , Alberton Anete , Ghedini Tatiana
Published: January 2024

O tema da “Diversidade e Inclusão” tem estado na agenda das organizações nas últimas décadas, devido à pressão dos movimentos da sociedade civil e da necessidade das empresas em atuar nos mercados globais. Mesmo assim, não houve avanços significativos no panorama da diversidade e da inclusão no mercado de trabalho, pois o preconceito sobre o desconhecido e sobre o diferente permanece. O objetivo deste estudo foi analisar as estratégias da abordagem dos vieses inconscientes nos programas de Diversidade e Inclusão no ambiente de trabalho das Big Four. A pesquisa realizou uma análise documental pela técnica de análise de conteúdo descritiva e a coleta de dados deu-se pelo acesso aos materiais corporativos de acesso público entre os anos de 2018 e 2022. No entanto, os primeiros relatórios incluídos na pesquisa foram a partir do ano de 2013, início da divulgação eletrônica. Dentre os resultados deste estudo, foi possível identificar que a neurociência se apresenta como base teórica e que o treinamento vem sendo a estratégia mais utilizada para esta abordagem. Percebe-se que a alta liderança das empresas tem se comprometido publicamente com metas de Diversidade e Inclusão e que nas quatro empresas se busca atingir níveis de diversidade também na composição da liderança em todos os níveis.
USO DE DADOS PARA SUBSIDIAR A TRANSFORMAÇÃO DIGITAL DAS ATIVIDADES OFERTADAS PELO COMPAZ ARIANO SUASSUNA
Authors: Batista Getulio Valdemir , Silva Edilene Maria da
Published: January 2024

No contexto atual, o uso de dados para tomada de decisão tornou-se um dos bens mais preciosos, mas que só agrega valor quando bem gerenciados. Essa nova realidade demanda atenção e esforços de toda a organização, desde os gestores estratégicos até os times operacionais. Dado o contexto do uso massivo das tecnologias da informação e comunicação, cumpre destacar que instituições, sejam públicas ou privadas, estão sendo desafiadas a prestarem serviços digitais e de alto valor para seus usuários. Para tal, o uso de dados constitui-se um dos elementos essenciais para operacionalizar a transformação digital, transformação essa que constitui um meio para reestruturação das organizações, de modo a tornarem-se mais eficientes em seus modelos de negócios e gerar valor para os serviços ofertados. Assim, o objetivo deste artigo é apresentar como o uso de dados pode ser uma ferramenta de suporte para a implantação da transformação digital das atividades ofertadas pelo Centro Comunitário Pela Paz - Ariano Suassuna. Para viabilizar o objetivo proposto este artigo se enquadra como descritivo, quanto à abordagem metodológica é qualitativo e como procedimento classifica-se como pesquisa-ação, realizada no Centro Comunitário pela Paz - Ariano Suassuna. Os resultados permitem visualizar onde os dados essenciais das atividades são utilizados e quais decisões podem ser tomadas a partir dele. Foram apresentados fatores críticos, forças, fraquezas, oportunidades e ameaças no contexto do uso de dados e informações do Compaz Ariano Suassuna. Conclui-se que o processo de transformação digital leva em consideração os dados e necessidades da organização, todavia apesar da cultura organizacional está caminhando para ser orientada a dados, muitos são os desafios que precisam ser superados.
A Novel Phytocolorant, Neoxanthin, as a Potent Chemopreventive:
Current Progress and Future Prospects
Authors: Parida Sudhamayee , Jena Mrutyunjay , Behera Akshaya Kumar , Mandal Amiya Kumar , Nayak Rabindra , Patra Srimanta
Published: January 2024

:

Cancer is a general term for a group of similar diseases. It is a combined process
that results from an accumulation of abnormalities at different biological levels,
which involves changes at both genetic and biochemical levels in the cells. Several modifiable
risk factors for each type of cancer include heredity, age, and institutional screening
guidelines, including colonoscopy, mammograms, prostate-specific antigen testing,
etc., which an individual cannot modify. Although a wide range of resources is available
for cancer drugs and developmental studies, the cases are supposed to increase by about
70% in the next two decades due to environmental factors commonly driven by the way
of living. The drugs used in cancer prevention are not entirely safe, have potential side
effects and are generally unsuitable owing to substantial monetary costs. Interventions
during the initiation and progression of cancer can prevent, diminish, or stop the transformation
of healthy cells on the way to malignancy. Diet modifications are one of the
most promising lifestyle changes that can decrease the threat of cancer development by
nearly 40%. Neoxanthin is a xanthophyll pigment found in many microalgae and
macroalgae, having significant anti-cancer, antioxidant and chemo-preventive activity.
In this review, we have focused on the anti-cancer activity of neoxanthin on different
cell lines and its cancer-preventive activity concerning obesity and oxidative stress. In
addition to this, the preclinical studies and future perspectives are also discussed in this
review.
Bile Acid-conjugate as a Promising Anticancer Agent: Recent Progress
Authors: Rathod Neha V. , Mishra Satyendra
Published: January 2024

Bile acids have outstanding chemistry due to their amphiphilic nature and have
received a lot of interest in the last few decades in the fields of biomedicine, pharmacology,
and supramolecular applications. Bile acids are highly sought after by scientists looking
for diverse and effective biological activity due to their chirality, rigidity, and hydroxyl
group. The hydroxyl group makes it simple to alter the structure in a way that improves
bioactivity and bioavailability. Bile acid-bioactive molecule conjugates are compounds in
which a bile acid is linked to a bioactive molecule by a linker in order to increase the bioactivity
of the bioactive molecule against the target cancer cells. This method has been
used to improve the therapeutic efficacy of cytotoxic drugs while reducing their adverse
side effects. These new bile acid conjugates are gaining attention because they overcome
bioavailability and stability issues. The design, synthesis, and anticancer effectiveness of
various bile acid conjugates are discussed together with recent advances in understanding
in this review.
Single-cell RNA Sequencing Analysis Reveals the Role of Cancerassociated Fibroblasts in Skin Melanoma
Authors: Lian Wenqin , Xiang Pan , Ye Chunjiang , Xiong Jian
Published: January 2024

Aims:

Mechanism of fibroblasts in skin melanoma (SKME) revealed by single-cell
RNA sequencing data.

Background:

SKME is responsible for more than 80% of skin-related cancer deaths. Cancer-associated
fibroblasts (CAFs) generate inflammatory factors, growth factors and extracellular matrix
proteins to facilitate cancer cell growth, metastasis, drug resistance and immune exclusion. However,
molecular mechanisms of CAFs in SKME are still lacking.

Objective:

Our goal was to reveal the role of CAFs in SKME.

Methods:

We downloaded the single-cell RNA sequencing (scRNA-seq) dataset from the Gene
Expression Omnibus (GSE215120) database. Then, the Seurat package was applied to analyze the
single-cell atlas of SKME data, and cell subsets were annotated with the CellMarker database.
The molecular mechanisms of CAFs in SKME were disclosed via differential gene expression and
enrichment analysis, Cellchat and SCENIC methods.

Results:

Using scRNA-seq data, three SKME cases were used and downscaled and clustered to
identify 11 cell subgroups and 5 CAF subsets. The enrichment of highly expressed genes among
the 5 CAF subsets suggests that cell migration-inducing hyaluronan-binding protein (CEMIP) + fibroblasts
and naked cuticle homolog 1 (NKD1) + fibroblasts were closely associated with epithelial
to mesenchymal transition. Cellchat analysis revealed that CAF subpopulations promoted melanocyte
proliferation through Jagged1 (JAG1)-Notch homolog 1 (NOTCH1), JAG1-NOTCH3
and migration through pleiotrophin (PTN)-syndecan-3 (SDC3) receptor-ligand pairs. The
SCENIC analysis identified that most of the transcription factors in each CAF subpopulation
played a certain role in the metastasis of melanoma and were highly expressed in metastatic
SKME samples. Specifically, we observed that CEMIP+ fibroblasts and NKD1+ fibroblasts had potential
roles in participating in immune therapy resistance. Collectively, we uncovered a single--
cell atlas of SKME and revealed the molecular mechanisms of CAFs in SKME development, providing
a base for immune therapy and prognosis assessment.

Conclusion:

Our study reveals that 5 CAFs in SKME have a promoting effect on melanocyte proliferation
and metastasis. More importantly, CEMIP+ fibroblasts and NKD1+ fibroblasts displayed
close connections with immune therapy resistance. These findings help provide a good basis for future
immune therapy and prognosis assessment targeting CAFs in SKME.
Integrating Single-cell and Bulk RNA-seq to Construct a Metastasis-related Model for Evaluating Immunotherapy and Chemotherapy in Uveal Melanoma
Authors: Du Yue , Jiang Xue , Zhang Yanyan , Ying Jianing , Yi Quanyong
Published: January 2024

Background:

Metastasis is a major cause of death in UM, highlighting the
need to use highly specific and sensitive prognostic markers to identify patients with a
risk of developing metastasis.

Aims:

The aim of this study was to improve the current precision treatment for patients
with metastatic uveal melanoma (UM).

Objective:

The objective of this work was to investigate the heterogeneity between primary
human UM and metastatic UM at the single-cell level and to discover potential
molecules regulating UM metastasis.

Methods:

Seurat R toolkit was employed to analyze single-cell sequencing data of UM
and to identify differentially expressed genes (DEGs) between primary and metastatic
UM. Least absolute shrinkage and selection operator (LASSO) and Cox regression analyses
were performed on the DEGs from the bulk RNA-seq cohort to develop a prognostic
model. Based on the model, patients were divided into high and low groups. The correlations
among the risk score, immune indicators, immune checkpoint blockade (ICB)
therapy, and anti-tumor drug therapy were analyzed.

Results:

Cell types in primary UM and metastatic UM tumors include B/plasma cells,
endothelial cells, melanocytes, monocytes/macrophages, photoreceptor cells, and T
cells. Among 157 DEGs between the two tumor types, S100A4, PDE4B, CHCHD10,
NSG1, and C4orf48 were selected to construct a prognostic model. The model could accurately
and independently predict response to ICB treatment and sensitivity to antineoplastic
drugs for UM patients as well as their immune infiltration levels, risk of death,
and metastasis possibility.

Conclusions:

This study analyzed the tumor ecosystem of primary and metastatic UM,
providing a metastasis-related model that could be used to evaluate the prognosis, risk
of metastasis, immunotherapy, and efficacy of antineoplastic drug treatment of UM.
New Emerging Aspect of Herbal Extracts for the Treatment of
Osteoporosis: Overview
Authors: Kumari Priyanka , Shirumalla Raj K. , Bhalla Vijay , Alam Md Sabir
Published: January 2024

As the global population ages, osteoporosis is becoming a more common silent disease.
Osteoporosis is characterized by decreased bone quality and strength, which increases the risk of
fragility fractures in the elderly. According to estimates, 50% of women eventually suffer from an
osteoporotic fracture. Due to increasing disability, more frequent hospital hospitalizations, and
most critically, fragility fractures have been linked to a reduced quality of life. Osteoporotic fractures
have been linked to an increased mortality risk; and must be considered in awareness as a serious
health concern. There are anti-osteoporotic medications available that improve bone quality.
Considering the availability of various treatment options, still there are a lot of underserved needs
in the treatment of fractures and osteoporosis. For example, the application of natural products
and herbal resources for fracture healing, because of the androgen-like and antioxidant characteristics
of the plants, they can play a crucial for accelerating the repair of bone fractures. In this article,
we’ll discuss the herbal remedies that are essential for treating osteoporosis (bone disease).
Stem Cells Reprogramming in Diabetes Mellitus and Diabetic Complications: Recent Advances
Authors: Madkor Hafez R. , Abd El-Aziz Mostafa K. , Abd El-Maksoud Mostafa S. , Ibrahim Islam M. , Ali Fares E.M.
Published: January 2024

Background:

The incidence of diabetes mellitus (DM) is dramatically increasing
worldwide, and it is expected to affect 700 million cases by 2045. Diabetes influences health care
economics, human quality of life, morbidity, and mortality, which were primarily seen extensively in developing countries. Uncontrolled DM, which results in consistent hyperglycemia, may
lead to severe life-threatening complications such as nephropathy, retinopathy, neuropathy, and
cardiovascular complications.

Methodology:

In addition to traditional therapies with insulin and oral anti-diabetics, researchers
have developed new approaches for treatment, including stem cell (SC) therapy, which exhibits
promising outcomes. Besides its significant role in treating type one DM (T1DM) and type two
DM (T2DM), it can also attenuate diabetic complications. Furthermore, the development of insulin-producing cells can be achieved by using the different types of SCs, such as embryonic stem
cells (ESCs), induced pluripotent stem cells (iPSCs), and multiple types of adult stem cells, such
as pancreatic, hepatic, and mesenchymal stem cells (MSC). All these types have been extensively
studied and proved their ability to develop insulin-producing cells, but every type has limitations.

Conclusion:

This review aims to enlighten researchers about recent advances in stem cell research and their potential benefits in DM and diabetic complications.
Preoperative T-staging of Colorectal Cancer by Dual-energy Computed
Tomography: A Retrospective Study
Authors: Qin Mi , Liu Manrong , Huang Ruisui , Gong Mofeng , Huang Haibo , Wei Xue , Wei Haotang , Lu Wei , Ding Ke
Published: January 2024

Background::

Preoperative T-staging is essential for planning optimal treatment and care for colorectal cancer (CRC).

Objective::

To evaluate the accuracy of Dual-energy CT (DECT) in preoperative T-staging of CRC.

Methods::

The clinical data and DECT images of 37 patients with 39 CRC lesions were retrospectively analyzed. The performance of the DECT quantitative
parameters in CRC T-staging was evaluated. Postoperative pathologic results were used as a gold standard. Receiver operating characteristic
curves were used to assess the diagnostic efficacy of DECT parameters. P & 0.05 was deemed significant.

Results::

The overall accuracy of T-staging by DECT was 76.9%. The DECT parameters were significantly different between the T3 pericolic fat stranding,
T4a pericolic fat stranding, and normal pericolic fat stranding. Arterial phase λHU had the best diagnostic performance with a cut-off value of
≥0.967, resulting in a 70.6% sensitivity and a 100% specificity in differentiating between T3 and T4a stages of CRC.

Conclusion::

DECT has high accuracy in the T-staging of CRC. Arterial phase λHU has the best diagnostic performance in differentiating between T3 and T4a
stages of CRC.
A Survey on Beamspace Millimeter-wave Massive Mimo Systems: An
Overview of Open Issues, Challenges, and Future Research Trends
Authors: Jayakumar Roscia Jeya Shiney , Arul Allwyn Clarence Asis
Published: January 2024

The channel sparsity is exploited by transforming the channel into an angular domain from
the spatial domain at millimeter wave frequencies in Beamspace Multiple-Input Multiple-Output
(B-MIMO) systems. Every beam in B-MIMO corresponds to an individual radio frequency (RF)
chain, and thus, beam selection techniques can reduce the RF hardware complexity. RF chain limitation
is needed for an ideal beamspace precoding scheme to attain good system performance across
the entire bandwidth. New methods of beamspace channel estimation with a small amount of estimation
error and low computational complexity are challenging in the beam domain due to the larger
antenna arrays deployed. A novel beamspace processing technique to improve the direction of arrival
estimation performance for different array configurations with improvement in system performance
is desired in a 5G system. A detailed review of the B-MIMO system with its architecture and various
beam selection techniques is presented in this paper. The scope of the work is elaborated by incorporating
various existing beamspace precoding and channel estimation methods. The paper also presents
various beamspace processing schemes for parameter estimation with a focus on the direction
of arrival estimation performance.
Optimized Multi-objective Clustering using Fuzzy Based Genetic
Algorithm for Lifetime Maximization of WSN
Authors: Pandey Shivendra Kumar , Singh Buddha
Published: January 2024

Background:

Wireless Sensor Networks (WSNs) have gained significant attention
due to their diverse applications, including border area security, earthquake detection, and fire
detection. WSNs utilize compact sensors to detect environmental events and transmit data to a
Base Station (BS) for analysis. Energy consumption during data transmission is a critical issue,
which has led to the exploration of additional energy-saving techniques, such as clustering.

Objective:

The primary objective is to propose an algorithm that selects optimal Cluster Heads
(CHs) through a fuzzy-based genetic approach. This algorithm aims to address energy consumption concerns, enhance load balancing, and improve routing efficiency within WSNs.

Methods:

The proposed algorithm employs a fuzzy-based genetic approach to optimize the selection of CHs for data transmission. Four key parameters are considered: the average remaining energy of CHs, the average distance between CHs and the BS, the average distance between member nodes and CHs, and the standard deviation of the distance between member
nodes and CHs.

Results:

The algorithm's effectiveness is demonstrated through simulation results. When compared to popular models like LEACH, MOEES, and FEEC, it demonstrates an 8-20% improvement in the lifetime of WSNs. The proposed approach achieves enhanced efficiency, lifetime extension, and improved performance in CH selection, load balancing, and routing.

Conclusion:

In conclusion, this study introduces a novel algorithm that utilizes fuzzy-based
genetic techniques to optimize CH selection in WSNs. By considering four key parameters and
addressing energy consumption challenges, the proposed algorithm offers significant improvements in efficiency, lifespan, and overall network performance, as validated through simulation results.
The Increase in E-commerce Purchases and the Impact on the Newest European City Logistics Development
Authors: Campisi Tiziana , Russo Antonio , Bouhouras Efstathios , Tesoriere Giovanni , Basbas Socrates
Published: January 2024

Background:

In recent times, the advancement of urban logistics has encountered a series of pivotal challenges pertaining to the efficient distribution of goods and associated concerns such as congestion and pollution. In response, efforts have been directed towards identifying enhanced solutions. Notably, the growing development of electronic commerce of electronic commerce has underscored the necessity of devising viable approaches, both functionally and economically, to bolster the evolution of city logistics. The document focuses on a comparative analysis of e-commerce purchase demand data in Europe, focusing on two product macro-categories, namely clothing and e-grocery. It points out that the pandemic, but the health crisis has accelerated this practice.

Objective:

The acquired findings unequivocally validate the necessity for a fundamental reassessment of delivery transport methods, taking into account the perishability of materials, sustainable urban accessibility, and the incorporation of cutting-edge technologies.

Methods:

The comparison in the different European contexts and the different trends recorded with the variation of the macro product categories was defined by QGIS maps and they underline how some of the states have restored their context of demand for mobility while others have preferred online commerce by reducing physical movements.

Results:

Analysis of the available data revealed that between 2020 and 2022 e-commerce concerning clothing, online food purchase and home delivery these are the findings; for the clothing category,, the distribution remained very similar; for the online food purchase category, the situation is quite similar and for home delivery category of ready-to-eat restaurant and fast-food food, many countries exceeded percentages of 20%.

Conclusion:

This could lead to an improvement in urban mobility planning, prompting an integration of these issues within the Sustainable Urban Mobility Plans (SUMPs) and at the same time it would allow logistics service managers to be able to introduce more sustainable and efficient modal forms.
Strategic Utilization of Microsimulation for Sustainable Traffic Analysis and Intersection Improvement
Authors: Riaz Malik Sarmad , Aziz Khizar , Mufeez Zeeshan Ali , Ghafoor Fazal e , Saker Louai , Aziz Kashif , Azab Marc
Published: January 2024

Background:

Traffic congestion is a worldwide challenge that poses significant economic, social, and environmental impacts. Countries worldwide, especially in urban areas, are confronted with the pressing challenge of managing traffic congestion.

Methods:

Traffic simulation can help create a model of the current situation of the state of the traffic and subsequently, simulate alternatives based on the current demand. To address this problem, this study aims to assess the traffic flow at a critical four-legged intersection (Sector G/11) in Islamabad, Pakistan, as a case study. It proposes a solution to alleviate traffic congestion using microsimulations. By utilizing software as a tool, we have created a model of the current state of the intersection, and, subsequently, proposed changes to the intersection's geometric features by designing an optimal solution for it.

Results:

The resulting modifications led to improved traffic flow, and reduced emissions and fuel consumption by 47%, minimized delays to 40%, resulting in an overall enhancement of the Level of Service from ‘E’ to ‘B’.

Conclusion:

Overall, this study demonstrates the potential benefits of using microsimulations in traffic management and underscores the need for innovative and sustainable solutions to address the complex issue of traffic congestion. The novelty of this paper lies in its pioneering approach of employing microsimulation techniques to analyze the intricacies of traffic conditions within a country like Pakistan, characterized by a multitude of factors contributing to congestion.
A literature review of Upavasa in PCOD w.r.t. Intermittent Fasting
Authors: Swapnali Sambhaji Patil  , More Sunil Sadashiv
Published: January 2024

Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine and metabolic diseases affecting women of childbearing age. It is associated with an increased prevalence of metabolic syndrome, cardiovascular diseases and type 2 diabetes. PCOD is major cause for infertility in today’s era. This metabolic syndrome affecting the females very fast but the treatment part for this is very restricted, as this is metabolic disease there is definitely scope in life style modification and reduce its severity of disease. In Ayurveda there is one type treatment known as Langhan, our Acharyas told that - Langhanam Param Aushadham, Upavasa is amongst one from Langhan Chikitsa. Many published studies indicate positive effects of fasting on PCOD.
Avascular Necrosis - A Conceptual Interpretation in Ayurveda
Authors: V Balendu Krishnan
Published: January 2024

Avascular Necrosis is a major health problem which results in the complete collapse of a Bone which may end up in permanent disabilities in the patient. Ayurveda with its vast concept of effective analysis and treatment aspects can be much fruitful in Avascular Necrosis cases without hampering other systems of the body. Here in this article an attempt is made to understand Avascular Necrosis by the concepts of Vatarakta in understanding its pathogenesis and its Treatment.
Alteration of Dinacharya and Ratricharya in Greeshma Ritu: An In-Depth Review
Authors: Nepal Prashanna , Ravi Sharma  , Umesh Shukla
Published: January 2024

Dinacharya are the activities which are done in a day. Similarly, Ratricharya are the activities done in the night. These regimens are described in sequences. There are separate sets of activities and guidelines to be followed during each season, collectively termed as Ritucharya. There are six seasons as per Ayurveda viz. Shishira, Vasanta, Greeshma, Varsha, Sharad and Hemanta. Although daily regimens have been advised for individuals, they might not be always applied for all the seasons. One needs to modify or alter certain activities in each season. Hence, this study is an effort that has been made to opt for following the sequence of Dinacharya in Greeshma Ritu based on Ayurvedic texts advocated for healthy individuals.