bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of urinary podocalyxin in early diagnosis of diabetic nephropathy
Authors: Kostovska Irena , Trajkovska Katerina Tosheska , Cekovska Svetlana , Topuzovska Sonja , Kavrakova Julijana Brezovska , Spasovski Goce , Kostovski Ognen , Labudovic Danica
Published: August 2020

Introduction. Podocyte injury has been reported as an early feature of DN therefore, the assessment of podocyte injury can be accomplished by estimation of podocalyxin in urine. This study aimed to estimate the urinary podocalyxin levels and to determine the sensitivity and specificity of this biomarker for early detection of DN.

Materials and methods. A total of 90 patients with type 2 diabetes mellitus (T2DM) were included in this cross-sectional study. Sixty of them were without diagnosed DN, and 30 with diagnosed DN. A control group consisted of 30 healthy subjects. All patients with T2DM were divided into three subgroups according to urinary microalbumin/creatinine ratio (UM/CR): normoalbuminuric, microalbuminuric and macroalbuminuric patients. Urine samples, were used for measurement of podocalyxin by ELISA, creatinine and microalbumin. Fasting venous blood samples was collected for biochemical analyses.

Results. The levels of urinary podocalyxin (u-PDX) were higher in patients with T2DM compared to control subjects and a statistically significant difference among studied subgroups regarding u-PDX was found (p < 0.05). Levels of u-PDX are increasing gradually with the degree of DN (p < 0.029). u-PDX levels were positively correlated with UM/CR (r = 0.227, p = 0.002). A cut-off level of 43.8 ng/ml u-PDX showed 73.3% sensitivity and 93.3% specificity to detect DN in early stage. A cut-off level of 30 mg/g UM/CR showed 41.5% sensitivity and 90% specificity in predicting DN. u-PDX was elevated in 48,2% of normoalbuminuric patients.

Conclusion. Urinary podocalyxin be useful and more sensitive and specific marker in early detection of DN than microalbuminuria.
Total Errors of TSH results by fluorescent immunoassay technique from dried blood spots in a newborn screening program for congenital hypothyroidism - variations in time
Authors: Oprea Oana Roxana , Zaharia Mihaela , Dobreanu Minodora
Published: August 2020

Objective:the aim of this study was to evaluate the imprecision of the method used to determine TSH (Thyroid Stimulating Hormone) levels from dried blood spots in a newborn screening program and how the value of the coefficient of variation influences the total error of the method.

Methods:A short-term evaluation of imprecision was compared with the imprecision of the method assessed over five years. The coefficient of variation from the best quality control period and the worst quality control period were used. For Bias assessment mean results from the external quality program were used. Total Error was calculated with Bias and Coefficient of Variation values. A freely available software was used for standard deviation and coefficient of variation profiling.

Results:The values of the coefficient of variation for the short-term were lower than values obtained in worst quality control period but higher than in the best quality control period. Total error was higher than the accepted value for low-level control in the worst quality control period. Images obtained with the software showed that for high-level control coefficient of variation is concentration-dependent but this finding is not similar for low-level control.

Conclusions:Total Error of the Method may be subject to change in time. Initial evaluation of imprecision must be performed on a short term analysis but a continuous evaluation should be performed as the performance of a method may change in time. The evaluation should be performed on clinically significant levels for each parameter.
“Aspects of an anti-Trump guerrilla campaign”
Authors: Stănese Radu
Published: August 2020

During the 2016 presidential election debates, Donald Trump became the subject of a guerrilla campaign initiated by the anarchist group Indicline, through which five grotesque nude statues of the Republican candidate were installed in various cities in the United States. The message was not accidental considering that nude photos of Melania Trump from the beginning of her modelling career were re-published simultaneously. Through aesthetic antithesis, the image of the naked body was supposed to stigmatize the couple in public perception, starting from an artificial reality created in the everyday landscape, but which had to become viral in the online environment.
The Practice of Open Innovation by SMEs in the Food Industry
Authors: Sadat S Hijrat , Nasrat Sayed
Published: August 2020

This paper examines the practice of open innovation by Small and Medium-sized Enterprises (SMEs) in the food industry. We adopted a multiple case study approach and conducted in-depth semi-structured interviews with four food SMEs in the Flanders region of Belgium. The results of the analysis show that food SMEs practice open innovation mostly through inbound open innovation activities rather than outbound, mainly due to lack of sufficient resources. Food SMEs typically lack sufficient financial capital, technology, and human capital. Within inbound open innovation activities, collaboration with organizations is found to be a key element for food SMEs’ internal development and innovation of new products.
In vitro response and effect of gamma irradiation on four local indica rice varieties
Authors: Islam Md. Monirul , Rahman Md Taufiqur , Hasanuzzaman Md. , Islam Md. Shahidul , Uddin Md. Imtiaz , Saha Nihar Ranjan
Published: August 2020

In vitro response of four local Indica rice cultivars viz. Sadamota, Kachamota, Moulata and Dudhkalam was evaluated. The aim of this study is to develop an efficient protocol for callus induction, plant regeneration and to observe the effect of gamma radiation on plant regeneration for creating possible genetic variability. In Different concentration of 2,4-D and growth regulators were supplemented with MS medium (Murashige and Skoog’s) to observe their callus induction frequency using mature embryo as explant. Among the cutivars, the highest primary callus (92.55%) as well as embryogenic callus induction (56.26%) was showed in sadamota at 3.0 mgl-1 2,4-D and 10 mgl-1 kinetin under dark condition. Twenty one days old embryogenic calli were exposed to 0, 2, 4 and 6 Gy of gamma rays and transferred to regeneration medium. Both callus growth and regeneration capacity were found to be decreased with increasing level of exposure to gamma rays. The doses of 4 Gy of gamma radiation were found to be the 50% inhibition dose for callus growth and plant regeneration in sadamota and kachamota, repectively whereas the 50% inhibition dose for moulata and dudhkalam at 2 Gy. This results indicate that sentivity of gamma radiation on rice callus depends on genotype of a genus.
Analysis Effect of Accrual Quality, Growth Opportunity and Gender Diversity on Firm Performance (Empirical Evidence from Listed Company in Indonesia Stock Exchange)
Authors: Fambudi Imam N. , Fitriani Dara
Published: August 2020

The research aims to analyze the relationship of accrual quality, growth opportunity, and gender diversity to firm performance which is divided into two-equation models namely Tobin's Q and ROA with control variables firm size, firm age and leverage using multiple regression analysis methods. The sample in this study is manufacturing companies listed on the Indonesia Stock Exchange from 2015 to 2017 with a total sample of 117 companies. The results showed that accrual quality and growth opportunity had a significant positive effect on the ROA model while gender diversity had a significant negative effect on Tobin's Q.
TRUE SALE ACCOUNTING ON SECURITIZATION IN INDONESIA
Authors: Heliantono Heliantono
Published: August 2020

Asset securitization is one of the financing solutions. One application for the use of asset securitization is in the residential mortgage sector. Securitization in Indonesia so far has been discussed in terms of financial management and legal aspects. This article discusses about securitization in Indonesia in term of accounting perspective. The accounting aspects of securitization transactions are based on the occurrence or non-occurrence of the derecognition of the financial assets securitized (true sale in accounting).  Asset securitization in Indonesia is carried out with the issuance of Asset-Backed Securities Collective Investment Contracts (KIK EBA) and Asset-Backed Securities in the form of Participation Certificate (EBA SP) with a total of 15 EBAs which are still traded at present. Eighty percent are residential mortgages backed securities (RMBS), the rest are non-RMBS.  The accounting treatment of securitization transactions conducted by the originator and in the event of an accounting true sale and non-true sale are discussed, also the securitization accounting treatment for originator, Special Purpose Vehicle (SPV), and investors. Broader socialization is needed so securitization can be applied in various economic activities to benefit national development in Indonesia
THE INFLUENCE OF AN AUDITOR'S EXPERTISE, OBEDIENCE PRESSURE, AND INDEPENDENCE ON AUDIT JUDGMENT
Authors: Sitanggang Tikkos
Published: August 2020

This study aims to empirically test whether the auditor’s expertise, obedience pressure, and independence  affects the audit judgment. The data used is the primary data through questionnaires that contain the answers of respondents. The population in this study auditor registered in the central Jakarta public accountant. The selected sample is 80 respondents with technical purposive sampling. This research uses quantitative method where the data obtained from questionnaire. Analysis of research data using multiple linear regression, with SPSS version 24. Based on the results of the analysis that has been done, this study shows that the auditor’s expertise, obedience pressure, and independence, have a positive and significant impact on the use of audit judgment compliance with adjusted R square of 74.7%. Partially, the results of this study indicate that auditor’s expertise, obedience pressure, and independence together positively and significantly influence the audit judgment.
ROLE OF AUDIT COMMITTEE IN THE FRAUD PENTAGON AND FINANCIAL STATEMENT FRAUD
Authors: Lastanti Hexana Sri
Published: August 2020

The research aims to detect financial statement fraud by means of Fraud Pentagon, with Audit Committee as a moderating variable. Variables applied in this research are a dependent variable in form of Financial Statement Fraud, an independent variable in form of Fraud Pentagon consisting of Pressure, Opportunity, Rationalization, Competence or Capability and, Arrogance factors, and Audit Committee as a moderating variable. Meanwhile, this research analyzes 49 manufacturing companies listed on Indonesia Stock Exchange (IDX) during 2016-2018 as the research sample and conducts 149 observations by means of a purposive sampling method. The research finds out that Pressure, Opportunity, and Rationalization determine Financial Statement Fraud with respect to the existence or inexistence of moderation by the size of Audit Committee. Other factors (i.e., Capability and Arrogance) most likely are insignificant to Financial Statement Fraud. This research suggests that the corporate management should cautiously take into account the Pressure factor measured by financial stability, the Opportunity factor measured by effective monitoring, and the Rationalization factor measured by change in auditor. Those three aspects are highly significant to Financial Statement Fraud. Besides, the corporate management should also enhance the effectiveness of Audit Committee because this variable is able to magnify the effect of Pressure, Opportunity, and Rationalization factors on Financial Statement Fraud.
The Discourse of Impressionism in Beta’s (B. V. Butkevich) Poetics
Authors: Silantev I. V. , Shatin Yu. V.
Published: August 2020

The article analyzes the impressionistic poetics of Boris Butkevich, a literary figure of the first wave of Russian emigration, a representative of the Harbin literary school. Like most impressionists, the composition of the poetic text by Boris Butkevich lacks a clearly defined beginning and end. The described lyrical situation can theoretically be continued in both directions. The reference points of impressions turn out to be significant, and not their poetic analysis. A similar principle is also found in the author’s prose, which largely repeats and develops the poetics of his lyric poems. Along with repeated melodic tricks in Butkevich’s prose, cross-cutting motives play an important role, passing from one text to another and organizing the unity of the cycle. At the same time, the author maintains the basic principle of impressionistic discourse – the paradoxical inconsistency of the scale of values. The value of an event is determined not by the accuracy of coincidences with the accepted doxes, but by the fact of a random incident of an event in the author’s field of vision.
Semantics of the Fictional Draft: Once again about B. L. Pasternak’s poem “A Fairy Tale” (“Skazka”)
Authors: Gelfond M. M.
Published: August 2020

The article deals with the fictional creative story of Boris Pasternak’s poem “The Fairy Tale” (“Skazka”), described in the novel “Doctor Zhivago”. It is fundamentally different from the real story: if Pasternak changed the plot and partly the genre of “The Fairy Tale”, as evidenced by his letter to Nina Tabidze, Yuri Zhivago in the novel changes the poetic meter twice – and at the same time comprehends its semantics. The differences between the real and the “novelistic” creative history focus on the semantic halo both of trochaic trimeter – the meter of “The Fairy Tale”, and of trochaic pentameter and trochaic tetrameter, used at starting of the first and intermediate edition. The article shows how the first edition, written in pentameter (trochaic or iambic), connects “The Fairy Tale” with “Hamlet” and “The Gethsemane Garden”. The assumption of a genetic link between the three texts and a few significant plot coincidences enables to find invariant embodiments of one lyrical plot in different genres in them. The triangle: “Hamlet” – “The Fairy Tale” – “The Gethsemane Garden” built within the cycle varies the most important topic of the cycle and the novel – the strategy of individual, personal confrontation with “the twilight of night” and “the years of timelessness”. The study of the second stage of the fictional story “The Fairy Tale” clarifies a number of Pushkin’s contexts, not only in the “Poems of Yuri Zhivago”, but also in the novel as a whole. The study of semantic halos arising at different stages of Zhivago’s work on “The Fairy Tale” allows including it in the context of Russian lyrics.
Ekphrasis as a Semiotic Experiment
Authors: Brazgovskaya E. E.
Published: August 2020

This article is focusing on two cognitive-semiotic processes: verbal representation of physical world objects and reverse translation of a sign into a thing – on creation of mental pictures based on verbal descriptions. Simultaneously, we study the cognitive-semiotic phenomenon of reading: the degree of certainty of mental images and their reliability which are determined by semiotic techniques of representation. The object of analysis are series of verbal pictures – representations of a work of art in Goran Petrovich’s novel “Atlas Composed by Sky”. The iconism of ekphrasis is the basis for the creation of gestalt paintings. According to the degree of iconism, there are distinguished the “absolute” copies (reproductions of pages of books and letters); ekphrasis in the form of a list of picture’s characters (icons as a schemes) and representations which creates the effect of “animated” or “living” pictures – like cinema images. The other side of the word is the image of another modality. The hidden multilingualism of verbal representations (for example, a visual image behind the verbal signs) explains why we not only see our mental images, but also hear, smell them and can touch their objects. So, the process of reading is based on working with «cognitive tango» of languages (L. Zbikowsky), where verbal system is presented in the current mode, while the visual image has a mental nature. This phenomenon of consciousness becomes the reason that missing (in direct perception) art objects become “real”. The possibility of a symbolic interpretation of mental images in the contexts of intellectual history allows us to define ekfrasis as more creative than mimetic practice.
Gestión deportiva en el contexto económico de Norte de Santander
Authors: Duarte-Rey Diego Mauricio
Published: August 2020

El deporte forma parte de lo que se llama cultura definida como el sistema de valores, costumbres, conductas y recreación que comparten con muchas personas y se usan en interacción con ellos mismos y su mundo. El deporte, actividad que permite ejercitarse, disfrutar recrearse, y que engloba un amplio valores, normas y comportamientos deportivos, que casi siempre son al Aire libre. Este trabajo investigativo descriptivo y cualitativos permite analizar el impacto económico que ha tenido la ciudad de Cúcuta desde el año 2012 desde el evento más importante del país como son los Juegos nacionales hasta el 2019 con inversiones en nuevas infraestructuras y adecuaciones deportivas que permiten que la ciudad pueda crecer y obtener más eventos deportivos de talla nacionales e internacional. La ciudad le ha apostado a que la económica de la ciudad pueda crecer por medio de invertirle al deporte y deportistas que representan el departamento y hace que muchas más personas puedan practicarlo e invertir no solamente recreativamente sino también competitivamente.
Avance de los factores protectores de la salud a través de la actividad instructiva en la enseñanza de la matemática
Authors: Mendoza Flores Derling Isaac , Flores Rodríguez Luz Marina , Mendoza Velazco Derling José
Published: August 2020

El articulo investigativo, tuvo como objetivo proponer actividades dirigidas para la promoción de los factores protectores de la salud a través de la actividad formativa en la enseñanza de la matemática dirigida a los estudiantes del Colegio Giordano Bruno de la ciudad de Quito - Ecuador (CGB), la misma se enfocó dentro de un diseño de campo de carácter descriptivo, bajo la modalidad de proyecto factible, la población se delimito por veinte (20) estudiantes que estudian en la institución antes descrita, para recopilar la información se aplicó la técnica de la observación y un cuestionario después de recopilado los datos de acuerdo a los hallazgos se elaboraron las conclusiones del diagnóstico, las cuales fomentaron la necesidad de la conformación de una propuesta para dar respuesta a los objetivos planteados. Dentro de la misma, se enmarcaron una serie de actividades que buscan transformar la práctica pedagógica ejecutada por los docentes asumiendo diferentes espacios de aprendizajes que realcen el proceso de aprendizaje que se requiere en la educación matemática afianzado a la salud. Asimismo, propiciar procesos participativos e innovadores que faciliten el conocimiento pero que a su vez sea pertinente con las necesidades e intereses de los estudiantes como los de su contexto. Por consiguiente, dar respuestas a cualquier necesidad relacionada con la salud debe ser el compromiso de la universidad como ente formador en la proyección de ambientes que propicie el sentido de pertenencia efectiva entre la institución, estudiantes y comunidad generando un clima de alta productividad.
KONTRIBUSI MINAT BACA TERHADAP KEMAMPUAN MEMBACA PEMAHAMAN SISWA
Authors: Halawa Noibe
Published: August 2020

AbstrakTujuan penelitian ini adalah mendeskripsikan kontribusi minat baca tinggi dan rendah, dengan model pembelajaran SQ3R dan konvensional dalam keterampilan  membaca pemahaman siswaPengambilan sampel penelitian dilakukan dengan teknik purposive sampiling, yaitu siswa kelas VII.4 sebagai kelas eksperimen berjumlah 32 orang yang dibelajarkan dengan model pembelajaran SQ3R dan siswa kelas VII.7 sebagai kelas kontrol berjumlah 32 orang yang dibelajarkan dengan model pembelajaran konvensional. Hasil thitung sebesar2,48 dan ttabel 1,746 pada taraf nyata α 0,05 dan dk 16 Jadi, th> tt maka Ho ditolak dan H1 diterima, artinya terdapat kontribusi yang signifikan model pembelajaran SQ3R terhadap keterampilan membaca pemahaman siswa yang memiliki minat baca tinggi. Keterampilan membaca pemahaman siswa yang memiliki minat baca tinggi yang dibelajarkan dengan model SQ3R lebih baik daripada siswa yang memiliki minat baca tinggi yang dibelajarkan dengan model pembelajaran konvensional. Hasil t hitung9,47 dan t tabel 1,746 pada taraf nyata α 0,05 dan dk 16. Jadi, th> tt maka Ho ditolak dan H1 diterima, artinya terdapat kontribusi yang signifikan model pembelajaran SQ3R terhadap keterampilan membaca pemahaman siswa yang memiliki minat baca rendah. Keterampilan membaca pemahaman siswa yang memiliki minat baca rendah yang dibelajarkan dengan model SQ3R lebih baik daripada siswa yang memiliki minat baca rendah yang dibelajarkan dengan model pembelajaran konvensional. Disimpulkan bahwa minat baca berkontribusi terhadap keterampilan membaca pemahaman.Kata kunci : Kontribusi, Minat Baca,  Membaca Pemahaman
ANALISIS IMPLEMENTASI PENDIDIKAN KARAKTER DALAM KONTEKS PENDIDIKAN UMUM MENURUT KAJIAN TEORI KRITIS JURGEN HUBERMAS
Authors: Dahliyana Asep , Rizal Ahmad Syamsu , Nurdin Encep Syarief
Published: August 2020

Pendidikan karakter bukan merupakan hal yang baru di Indonesia. Akan tetapi, implementasi pendidikan karakter di sekolah hasilnya tidak begitu menyenangkan. Pendekatan yang digunakan dengan dirumuskannya mata kuliah wajib dalam konteks pendidikan umum yang diproses melalui bangku perkuliahan kurang memuaskan. Pendekatan yang digunakan untuk memperoleh data yaitu dengan mix method yaitu melalui teknik survey dan wawancara. Hasil penelitian menunjukkan bahwa (1) implementasi pendidikan karakter di Indonesia baru pada tataran nilai 2,65; (2) implementasi pendidikan karakter terhadap perkembangan karakter peserta didik belum dapat optimal sebab kurangnya pelatihan-pelatihan kepada pendidik; (3) implementasi pendidikan karakter dalam konteks pendidikan umum masih lemah, sebab pendidikan umum masih mengalami tumpang tindih dengan ranah disiplin ilmu lainnya.
Reabilitação oral conservadora em paciente juvenil com alterações orofaciais secundárias ao tratamento de rabdomiossarcoma em cabeça e pescoço: relato de caso / Conservative oral rehabilitation in a juvenile patient with orofacial alterations secondary to the treatment of rhabdomyosarcoma in the head and neck: case report
Authors: Moreira Paula Guimarães , Mendonça Regina Maria Holanda de , Santos Paulo Sérgio Da Silva , Cappellaro Katia Maria Coutinho , Silva Luis Cândido Pinto da
Published: August 2020

Introdução: O tratamento antineoplásico multimodal para tumores em cabeça e pescoço de crianças frequentemente acarreta distúrbios de desenvolvimento em dentes e estruturas faciais. Dentre as alterações observadas estão as anomalias ósseas, agenesias dentárias, microdontia, anomalias de esmalte e, sobretudo, malformações radiculares e coronárias.A frequência e intensidade dessas alterações estão relacionadas com a idade da criança durante o tratamento, a modalidade terapêutica, o tipo de quimioterápico, a dose de radiação e o campo irradiado. Objetivo/Relato de Caso: Este trabalho tem como objetivo descrever o tratamento reabilitador oral conservador, por meio de confecção de prótese total superior do tipo overdenture, em paciente juvenil com severos distúrbios de desenvolvimento dentário e ósseo, consequentes do tratamento de rabdomiossarcoma em nasofaringe realizado aos dois anos de idade. Conclusão: Este relato enfatiza a importância do acompanhamento odontológico regular de pacientes pediátricos irradiados em face, até que o crescimento facial se complete, permitindo a manutenção da função e estética.Palavras Chave: Reabilitação bucal, Pediatria, Rabdomiossarcoma, Face, NasofaringeABSTRACTIntroduction: Multimodal antineoplastic treatment for tumors in the head and neck of children often leads to developmental disorders in teeth and facial structures. Among the alterations observed are bone anomalies, dental agenesis, microdontia, enamel anomalies and, mainly, root and coronary malformations. The frequency and intensity of these changes are related to the age of the child during treatment, the therapeutic modality, the type of chemotherapy, the radiation dose and the irradiated field. Aim/Report Case: This work aims to describe the conservative oral rehabilitation treatment, by means of the construction of a superior overdenture, in a patient with severe dental and bone developmental disorders resulting from the treatment of nasopharyngeal rhabdomyosarcoma performed at two years of age. Conclusion: This report emphasizes the importance of regular dental follow-up of pediatric irradiated patients on the face, until facial growth is complete, allowing maintenance of function and aesthetics.Keywords: Mouth rehabilitation, Pediatrics, Rhabdomyosarcoma, Face, Nasopharynx
Distinct RNA N-Demethylation Pathways Catalyzed by Non-Heme Iron ALKBH5 and FTO Enzymes Enable Regulation of Formaldehyde Release Rates
Authors: Toh Joel D.W. , W. M. Crossley Steven , Bruemmer Kevin , Ge Eva J. , He Dan , Iovan Diana , Chang Christopher
Published: August 2020

Abstract

The AlkB family of non-heme-Fe(II)/2-oxoglutarate(2OG)-dependent oxygenases are essential regulators of RNA epigenetics by serving as erasers of one-carbon marks on RNA with release of formaldehyde (FA). Two major human AlkB family members, FTO and ALKBH5, both act as oxidative demethylases of N6 methyladenosine (m6A) but furnish different major products, N6 hydroxymethyladenosine (hm6A) and adenosine (A), respectively. Here we identify foundational mechanistic differences between FTO and ALKBH5 that promote these distinct biochemical outcomes. In contrast to FTO, which follows a traditional oxidative N-demethylation pathway to catalyze conversion of m6A to hm6A with subsequent slow release of A and FA, we find that ALKBH5 catalyzes a directm6A-to-A transformation with rapid FA release. We identify a catalytic R130/K132/Y139 triad within ALKBH5 that facilitates release of FA via an unprecedented covalent-based demethylation mechanism with direct detection of a covalent intermediate. Importantly, a K132Q mutant furnishes an ALKBH5 enzyme with an m6A demethylation profile that resembles that of FTO, establishing the importance of this residue in the proposed covalent mechanism. Finally, we show that ALKBH5 is an endogenous source of FA in the cell by activity-based sensing of FA fluxes perturbed via ALKBH5 knockdown. This work provides a fundamental biochemical rationale for non-redundant roles of these RNA demethylases beyond different substrate preferences and cellular localization, where m6A demethylation by ALKBH5 versus FTO results in release of FA, an endogenous one-carbon unit but potential genotoxin, at different rates in living systems.

Significance Statement

Non-heme iron enzymes FTO and ALKBH5 play central roles in epigenetic RNA regulation by catalyzing the oxidation of N6-methyladenosine (m6A) to produce N6-hydroxymethyladenosine (hm6A) and adenosine (A), respectively. Here, we provide a mechanistic rationale for these distinct biochemical outcomes by identifying that ALKBH5 performs m6A demethylation via an unprecedented covalent-based mechanism with concomitant and rapid release of A and formaldehyde (FA), whereas FTO liberates hm6A to release A and FA over longer timescales. This work reveals foundational biochemical differences between these closely related but non-redundant epigenetic enzymes and identifies ALKBH5 as an endogenous source of rapid formaldehyde generation in cells.
Defluorosilylation of Trifluoromethane: Upgrading an Environmentally Damaging Fluorocarbon
Authors: Sheldon Daniel , Coates Greg , Crimmin Mark
Published: August 2020

The rapid, room-temperature defluorosilylation of trifluoromethane, a highly potent greenhouse gas, has been achieved using a simple silyl lithium reagent. An extensive computational mechanistic analysis provides a viable reaction pathway and demonstrates the unexpected electrophilic nature of LiCF3. The reaction generates a bench stable fluorinated building block that shows promise as an easy-to-use difluoromethylating agent. The difluoromethyl group is an increasingly important bioisostere in active pharmaceutical ingredients, and therefore our methodology creates value from waste. The potential scalability of the process has been demonstrated by achieving the reaction on a gram-scale.
One-Step Synthesis of Acylboron Compounds via Cu-Catalyzed Carbonylative Borylation of Alkyl Halides
Authors: Li-Jie Cheng , Siling Zhao , Mankad Neal
Published: August 2020

A Cu-catalyzed carbonylative borylation of unactivated alkyl halides has been developed, enabling efficient synthesis of aliphatic potassium acyltrifluoroborates (KATs) in high yields by treating the in-situ formed tetracoordinated acylboron intermediates with aqueous KHF2. A variety of functional groups are tolerated under the mild reaction conditions, and primary, secondary and tertiary alkyl halides are all applicable. In addition, this method also provides facile access to N-methyliminodiacetyl (MIDA) acylboronates as well as α-methylated potassium acyltrifluoroborates in a one-pot manner. Mechanistic studies indicate a radical atom transfer carbonylation (ATC) mechanism to form acyl halide intermediates that are subsequently borylated by (NHC)CuBpin.
Lockdown Lifestyle: Engaging the invisible Enemy
Authors: Tejas N. Wanjari  , Gaurav Sawarkar
Published: August 2020

At present, COVOID-19 has created such a worse pandemic situation worldwide. The virus is responsible for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). During quarantine, outside, there is the danger of getting physically sick due to infection (spreads with social contact) and inside due to mental and psychological stiffness. Once found proof of a range of psychological conditions during previous epidemics such as SARS, from post-traumatic stress symptoms to confusion, anger, depression, stress, insomnia, and emotional exhaustion. It is essential to look over schedule during this lockdown. From the sleeping time, exercise, diet, remain physically and mentally calm and relaxed. An estimated 2.6 billion people – one-third of the world's population – are living under some lockdown or quarantine. This is arguably the most massive psychological experiment ever conducted. There was no option to combat the COVID-19 crisis. Lockdown helps to break the chain of virus scattering in society and to minimize the disease rate as well as control the mortality rate. People didn’t seem aware of how to face or schedule the lockdown period, and that creates a panic situation in the society. Thus, it is necessary to plan out the lockdown schedule to overcome physical as well as mental illness.
Experience of managing covid-19 suspected case in labour in a green zone district tertiary care hospital
Authors: Priyanka Singh  , Neema Acharya  , Neha Verma
Published: August 2020

Coronavirus disease 2019 (COVID-19) is a novel type of highly contiguous pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Pregnant ladies are vulnerable to the virus infection due to alteration in anatomic and immune system. The chance of infection would apparently rise due to antenatal visits but inadequate medical care facilities during pregnancy can be harmful for both maternal and perinatal outcome. The Government of India has divided the districts of various states into Red, Orange and Green zones. Most of the hospitals from Red and Orange zones have made it mandatory COVID -19 testing for all antenatal patients near term making it easier to isolate and manage patients accordingly. The green zone hospital presently not doing COVID testing for all peripartum patients. Thus, proper maternal health care management at tertiary level is required with minimum exposure and risk in suspected cases especially in green zone hospitals. Here, we present our experience as a team at our Obstetrics and Gynaecology department of pregnant women with upper respiratory tract infection/suspected case of COVID-19 infection during hospitalization in our rural setup and further we will discuss patient triage based on risk level, antenatal care planning and handling emergencies during COVID- 19 lockdown.
ANALISIS YURIDIS MEKANISME PEMAKZULAN PRESIDEN DAN WAKIL PRESIDEN MENURUT UUD NEGARA REPUBLIK INDONESIA TAHUN 1945 (SETELAH PERUBAHAN)
Authors: Arifin Zainal
Published: August 2020

The term impeachment is not explicitly written in the constitution. In Big Indonesian Dictionary New Edition deposed mentioned is put positions; king abdicated. Prof. Jimly Asshiddiqie explained, impeachment is the uptake of the Arabic language which means derived from office. Or equal to the term 'impeachment ' in the constitution of Western countries. Dismissal of the President and / or Vice President of the mechanism is already provided for in Article 7A and 7B 1945. Prior to MPR dismiss both the President and / or Vice President , the mechanisms that must be taken is the first , the proposed dismissal of the President and / or Vice- president of the Board House of Representatives to the Assembly with only first submit a request to the Constitutional Court to examine, and decide upon the opinion of the House that the President and / or Vice President has violated the law in the form of treason against the State , corruption , bribery , criminal acts other heavy , or moral turpitude ; and / or opinions that the president and / or vice president is no longer eligible as president and / or vice president.
ANTRIAN GERBANG KELUAR PARKIR DI UNIVERSITAS JENDERAL ACHMAD YANI CIMAHI
Authors: Damayanto Antono , Virgiawan Fernanda , Juana Prima Sukma , Pratama Yogi
Published: August 2020

Abstract The number of vehicles at Jenderal Achmad Yani University continues to increase, thus requiring increased parking security on campus. For this reason, Jenderal Achmad Yani University implemented a paid parking gate system, but this turned out to have an impact on the emergence of a long vehicle queue at the parking exit gate. This study aims to find a solution to minimize the length of the queue at the parking gate. In this study two alternatives are proposed, namely adding ticket booths (Alternative 1) or improving service time by using an automatic card system (Alternative 2). The results obtained show that for the next 5 years, Alternative 1 needs to add 1 ticket booth and Alternative 2 does not need to add ticket booth. For the next 10 years, Alternative 1 needs to add 1 more ticket booth in 2027, while Alternative 2 requires the addition of 1 ticket booth in 2026. Keywords: parking, queue, service time, automatic card system  Abstrak Jumlah kendaraan di Universitas Jenderal Achmad Yani meningkat terus, sehingga memerlukan peningkatan keamanan parkir di kampus. Dengan alasan itu, Universitas Jenderal Achmad Yani menerapkan sistem gerbang parkir berbayar, tetapi hal ini ternyata berdampak pada timbulnya antrian kendaraan yang panjang di gerbang keluar parkir. Tujuan penelitian adalah mencari solusi untuk meminimalkan panjang antrian di gerbang keluar parkir. Pada studi ini diusulkan 2 alternatif, yaitu menambah gardu (Alternatif 1) atau memperbaiki waktu pelayanan dengan menggunakan sistem kartu otomatis (Alternatif 2). Hasil yang didapat menunjukkan bahwa untuk 5 tahun mendatang Alternatif 1 perlu menambah 1 gardu dan Alternatif 2 tidak perlu menambah gardu. Untuk 10 tahun mendatang, Alternatif 1 perlu menambah 1 gardu lagi pada tahun 2027, sedangkan Alternatif 2 membutuhkan penambahan 1 gardu pada tahun 2026. Kata-kata kunci: parkir, antrian, waktu pelayanan, sistem kartu otomatis
Et Dionysos sortit des flots… Dionysos et la mer sur les mosaïques des salles de réception
Authors: GUİMİER-SORBETS Anne-marie
Published: August 2020

Dionysos had to jump into the sea in order to escape from Lycurgos; in another episode, the god was attacked by Tyrrhenian pirates who were transformed into dolphins. These two little known episodes of the myth of the god are depicted, directly or indirectly, on the pavements of reception halls. We will first study this iconography on the mosaics of the Hellenistic period, and then on those of the Imperial period, and pay particular attention to the scenes of the marine triumph of Dionysos (Dion, Corinth) and on the depiction of black swimmers (Pompeii, North Italy, the Narbonnaise). In line with the works of Jean-Pierre Darmon, we will inquire into the transmission of iconographic schemes through the ages, first in the Greek koine and then in the Roman Empire; and, finally, into their meaning according to architectural contexts in which they are found.
O SMARTPHONE NA SALA DE AULA DE LÍNGUA INGLESA: integrando artefato e tarefas pela abordagem da Teoria Ator-Rede
Authors: Khatchadourian Luana De França Perondi
Published: August 2020

O presente artigo é parte uma pesquisa de doutorado em linguística aplicada cujo objeto é o uso do aparelho celular do tipo smartphone na sala de aula de lingua inglesa em escolas públicas de periferia. O uso do aparelho celular em sala de aula já foi proibido e hoje é liberado para uso pedagógico. Mas o que seria, de fato, uso pedagógico? Liberar tal artefato no contexto escolar pressupõe dizer como ele deve ser apropriado? Com base na teoria ator-rede de Bruno Latour e colegas, este trabalho defende a tese de que o aparelho celular precisa ser tratado como um elemento mediador inserido em toda uma rede de agências e agentes que constitui o que chamamos de aula, e que o efeito da sua entrada na sala de aula depende das diferentes relações entre atores humanos e não-humanos que já ocorrem nessa rede. Toma-se por hipótese que usando-se a aprendizagem baseada em tarefas e mobile language assisted learning é possível possível integrar o aparelho ao fluxo do ensino-aprendizagem sem descaracterizar excessivamente o potencial desse artefato na vida real, e, ao mesmo tempo, mantendo-se a sala de aula produtiva, gerando aprendizagem, mesmo que de forma diferente da tradicional.
DE QUE FORMA AS AVALIAÇÕES ESCOLARES E OS EXAMES DE LARGA ESCALA DE LÍNGUA PORTUGUESA SÃO INSTRUMENTOS PARA EDUCAR E FORMAR PESSOAS COM PENSAMENTO REIFICADO E ALIENADO?
Authors: Baron Roberto , Baltar Marcos Antonio Rocha
Published: August 2020

O artigo descreve os efeitos da padronização social, étnica, cultural, histórica e geográfica a que são submetidos estudantes brasileiros que participam das provas de língua portuguesa nas escolas e de exames de larga escala como o vestibular, o ENEM e PISA. Problematiza-se, através da Linguística Aplicada, da teoria crítica de gêneros e da teoria crítica de Adorno, Letramentos, e Análise do Discurso de linha francesa, as avaliações escolares e exames de larga escala que medem e diagnosticam problemas de aprendizagem no ensino da língua portuguesa ao questionar de como as avaliações e exames se transformaram em instrumentos de submissão, dominação, reificação e alienação por meio da educação e não num instrumento de libertação e formação de cidadãos com autonomia de decisão.
A case of partial leucism in the Blue-black Grassquit (Volatinia jacarina) from Venezuela
Authors: Verea Carlos
Published: August 2020

Reports of plumage aberrations in wild birds, as well as their distribution and frequency, are important because of their implications in bird conservation, since they are likely associated with environmental factors (e.g. contamination), population genetics, population size (e.g. endogamy) or nutrition (e.g. resource scarcity). This article documents a case of plumage aberration in a Blue-black Grassquit (Volatinia jacarina) female individual sighted and photographed in a suburban area of northern Venezuela. The aberrant individual was mostly (> 70%) white, except for the crown, wings (primary feathers and its coverts), crisum, and tail. The white plumage showed a symmetrical distribution pattern. The eyes, tarsi and beak had normal pigmentation. Based on literature consulted and a dichotomous key to identify pigmentary abnormalities, the plumage aberration corresponds to partial leucism. This record constitutes the first case of leucism for the Blue-black Grassquit in Venezuela, and adds to other observations of plumage aberration in wild birds of the Neotropical area.
Evaluating and Ranking the Development level of Rural Areas of Tabriz using Copeland Model and Comparison the Results with Topsis, Vikor and Electre Models
Authors: HEİDARZADEH Soheila , POURDARBANİ Razieh , ZADVALİ Fatemeh , PASHAZADEH Asghar
Published: August 2020

Agricultural development is a major part of the rural development process, and it is impossible to imagine a developed world without agricultural development. Thus, the purpose of this study was to determine the level of agricultural development in Tabriz rural areas and to rank them in terms of agricultural development using Topsis, Vikor, Electre, and Copeland models. In this study, 8 agricultural criteria including level of Education, area of fields and orchards, mechanization level, livestock, fish farming, service-support and yield were used. The weight of the criteria was determined by paired comparison method and all the analysis steps were performed by Excel software and finally GIS software was used to produce the map. The results indicated that in the Topsis model, Lahijan was ranked first and Ajichai was the last, and in the Vikor model, Lahijan was ranked first and Maidanchai was the last. Thus to obtain consensus on the results of the models, Copeland method was used. Copeland's method is a Condorcet method in which the winner is determined by finding the candidate with the most pairwise victories. According to the Copeland model, Lahijan and Ajichai were ranked first and sixth, respectively. The status of all the considered rural areas was at "in developing" status. Coefficient of variation showed that fish farming criteria (CV=2.24) had the most distribution inequality among the villages and rice yield criteria (CV=0) had the most suitable distribution among the villages.
Is The Natural Honey Bee Biodiversity of Anatolia in the Process of Extinction?
Authors: KAMBUR Merve , KEKEÇOĞLU Meral
Published: August 2020

This study was conducted through the geometric morphometric method by making a sampling as to represent seven geographical regions of Turkey and also all honeybee races that are reported to be found in Turkey. Nineteen landmarks on the wings of bees detected by using right front wings of worker bees were measured by the Bs200Pro program. According to the results of discriminant function analysis based on individual data, the true classification rate was found to be 54.1%. While the Marmara, Aegean, Eastern Anatolia and Black Sea Regions formed a strictly single group, the Southeastern Anatolia Region distinctly separated from other regions. The honey bee population of eastern and western parts of the Mediterranean Sea were divided into two, while the western part formed close groups with other regions, the eastern part got closer to the Southeastern Anatolia Region. The group center of the Central Anatolia Region partly separated from the other regions and formed a group at the edge. Beside the split of the Mediterranean Region as East and West, the samples taken from Southeastern Anatolian Region create a separate group supported the existence of Apis mellifera syriaca and Apis mellifera meda races in the South. The separation of the Central Anatolia Region supports the existence of Apis mellifera anatoliaca in Central Anatolia of Turkey. However, the examples taken from other regions nested together to create a group show that the honey bee biodiversity in Turkey has been affected by the migratory beekeeping and commercial queenbee activities in recent years.
Bazı Ağaç Yapraklarının İn Vitro Gaz Üretim Tekniğiyle Yem Değerlerinin Belirlenmesi
Authors: ÖZDEMİR Özlem , KAYA Adem
Published: August 2020

Erzurum ilinde doğal olarak yetişen, akasya (Robinia pseudocacia L), kayın (Fagos adsidue), meşe (Quercus L), salkım söğüt (Salix alba) ve kavak (Populus L) ağaçlarına ait gazel formundaki yaprakların in vitro gaz üretim tekniği ile yem değerlerinin belirlenmesi amacıyla yürütülen çalışmada, in vitro gaz üretim tekniğinde kullanılan rumen sıvısı 2 yaşlı 2 baş İvesi koçtan temin edilmiştir. Kimyasal kompozisyonlarına ait ortalama değerler bakımından ağaç yaprakları arasındaki farklar önemli bulunmuştur (p<0.01). En yüksek HP içeriği ve en düşük NDF, ADF ve ADL değerleri akasya yaprağında saptanmıştır. Mevcut çalışmada, ağaç yapraklarına ait 24 saatlik gaz üretimi, ME, NEL, OMS ve metan üretim değerleri sırasıyla 17.33-31.00 ml/200 mg KM, 4.61- 7.03 MJ/kg KM, 3.18-4.53 MJ/kg KM, %35.43-50.02 ve 2.70-3.01 ml/200 mg KM arasında belirlenmiştir. En yüksek ME, NEL ve OMS ile gaz üretimi değerlerine ve en düşük tanen içeriğine kayın yaprağının sahip olduğu belirlenmiştir. En düşük metan ve in vitro gaz üretimi meşe yaprağında saptanmıştır. Ağaç yapraklarına ait nisbi yem değerlerinin (NYD) 138.88-278.04 arasında değiştiği ve meşe yaprağı hariç incelenen diğer yaprakların en iyi kaliteye sahip oldukları tespit edilmiştir. Sonuç olarak bu çalışamadan elde edilen in vitro verilere dayanarak; yeterli miktar ve kalitede kaba yemin temin edilemediği dönemlerde yüksek kondanse tanen içeriğine sahip olan akasya, söğüt ve kavak yapraklarının kaba yem rasyonlarının belli bir kısmını oluşturabileceği, özellikle kayın yaprağının ruminantların beslenmesi açısından iyi bir alternatif yem kaynağı olabileceği belirlenmiştir Ancak, ruminant hayvan beslemede ağaç yapraklarının gerçek besleyici değerlerini belirlemek için in vitro çalışmaların yanı sıra in vivo çalışmaların da yapılması gerektiği kanaatine varılmıştır.
Factors Affecting the Adoption of Innovations in Dairy Cattle Farms in TR22 South Marmara Region of Turkey
Authors: ÖZSAYIN Damla
Published: August 2020

The present study was aimed to define the factors affecting the adoption of innovations in dairy cattle farms in Balıkesir and Çanakkale provinces in TR22 South Marmara Region, Turkey. The data were collected from 221 farms by a stratified random sampling method. The study was performed between March and November 2019. This study was used the ordered probit model to evaluate the data. The results revealed that the age of the farmers, household size, dairy cattle experience, household income, the number of dairy cattle, frequency of the internet use, meeting frequency with other farmers and contact frequency with agricultural extension personnel had a positive impact on farmers' adoption of innovations; whereas farmers' contact frequency with veterinaries had a negative impact. As a result, farmers' adoption of innovations in dairy farming activity can be increased with farmers who are open to innovations regarding animal husbandry and knowledgeable about the importance and the necessity of innovations adoption
PENERAPAN MODEL PREDICT OBSERVE EXPLAIN BERBANTUAN MEDIA SCRAPBOOK UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA SD
Authors: Linda Ayu Kusumaningsih  , Fakhriyah Fina , Roysa Mila
Published: August 2020

This study aims to describe the increase in critical thinking skills using the predict observe explain learning model assisted by scrapbook media in class V SD 1 Jepang Kudus. This type of research is classroom action research. This type of research is classroom action research. This research consists of 4 stages namely planning, action, observation, and reflection. The research was conducted in 2 cycles with 2 meetings each cycle. The subjects of this study were 27 students of grade V SD 1 Jepang Kudus in the 2019/2020 school year. The results showed that students' critical thinking skills in cycle 1 obtained classical completeness by 63% with the criteria needed guidance, while in cycle 2 they obtained classical completeness by 85% with good criteria.