bluuebunny/crossref_metadata_2025 huggingface dataset:
In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model
Authors: Rudy Shannon F. , Brenner J. Chad , Harris Jennifer L. , Liu Jun , Che Jianwei , Scott Megan V. , Owen John Henry , Komarck Christine M. , Graham Martin P. , Bellile Emily L. , Bradford Carol R. , Prince Mark EP , Carey Thomas E.
Published: April 2016

Background

Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic agent.

Methods

We tested anti-metastatic effects of a WNT pathway inhibitor, WNT974 (also known as LGK974), which targets porcupine (PORCN) the palmityl-transferase that is essential for secretion of Wnt proteins. CAM assays were performed with 8 HNSCC cell lines: UM-SCC-1, UM-SCC-10A, UM-SCC-10B, UM-SCC-11A, UM-SCC-14A UM-SCC-17A, UM-SCC-17B, UM-SCC-25, and UM-SCC-34.

Results

UM-SCC-1 (University of Michigan Squamous Cell Carcinoma cell line) CAM xenografts contain CD44+ and ALDH+ cancer stem cell (CSC) proportions similar to UM-SCC-1 mouse xenografts supporting the applicability of the CAM assay for study of CSCs. Inhibition of WNT signaling by the PORCN inhibitor WNT974 reduced metastatic spread of UM-SCC cells, especially in UM-SCCs with Notch1 deficiency.

Conclusions

Our data demonstrate decreased tumor growth and metastases in tumors from cell lines that showed in vitro responses to WNT974, providing evidence that this agent may have a role in future HNSCC therapy.
Response to Cetuximab With or Without Irinotecan in Patients With Refractory Metastatic Colorectal Cancer Harboring the KRAS G13D Mutation: Australasian Gastro-Intestinal Trials Group ICECREAM Study
Authors: Segelov Eva , Thavaneswaran Subotheni , Waring Paul M. , Desai Jayesh , Robledo Kristy P. , Gebski Val J. , Elez Elena , Nott Louise M. , Karapetis Christos S. , Lunke Sebastian , Chantrill Lorraine A. , Pavlakis Nick , Khasraw Mustafa , Underhill Craig , Ciardiello Fortunato , Jefford Michael , Wasan Harpreet , Haydon Andrew , Price Timothy J. , van Hazel Guy , Wilson Kate , Simes John , Shapiro Jeremy D.
Published: April 2016

Purpose

RAS mutations predict lack of response to epidermal growth factor receptor monoclonal antibody therapy in patients with metastatic colorectal cancer (mCRC), but preclinical studies and retrospective clinical data suggest that patients with tumors harboring the exon 2 KRAS G13D mutation may benefit from cetuximab. We aimed to assess cetuximab monotherapy and cetuximab plus irinotecan in patients with molecularly selected (G13D mutation) chemotherapy-refractory mCRC in a randomized phase II trial of this rare molecular subtype.

Patients and Methods

Patients with chemotherapy-refractory KRAS G13D mutation–positive mCRC who had progressed within 6 months of irinotecan therapy were randomly assigned to cetuximab 400 mg/m2 loading dose and then 250 mg/m2 once per week with or without irinotecan 180 mg/m2 once every 2 weeks. The primary end point was 6-month progression-free survival; secondary end points were response rate, overall survival, quality of life, and toxicity.

Results

Fifty-one of 53 patients recruited over 2 years were eligible. The 6-month progression-free survival rate was 10% (95% CI, 2% to 26%) for cetuximab versus 23% (95% CI, 9% to 40%) for cetuximab plus irinotecan with a hazard ratio of 0.74 (95% CI, 0.42 to 1.32). Response and stable disease rates were 0% and 58% for monotherapy versus 9% and 70% for combination treatment, respectively. Overall survival and quality of life were similar; toxicities were higher with combination therapy.

Conclusion

In patients with G13D-mutated chemotherapy-refractory mCRC, there was no statistically significant improvement in disease control at 6 months with either cetuximab monotherapy or cetuximab plus irinotecan. No responses were seen with single-agent cetuximab. The responses observed with the combination of cetuximab and irinotecan may reflect true drug synergy or persistent irinotecan sensitivity. The ICECREAM (Irinotecan Cetuximab Evaluation and Cetuximab Response Evaluation Among Patients with a G13D Mutation) study demonstrates the need to prospectively evaluate hypotheses that were previously supported by retrospective analyses and exemplifies the value of international collaboration in trials of rare molecular subtypes.
THE HOUSE
Authors: Bynum Caroline Walker
Published: April 2016

Caroline Walker Bynum has written extensively about medieval religious objects and about the background to medieval understandings of materiality in theology, natural philosophy, and science. Here she turns to a very different consideration of objects, asking how they reflect and sharpen personal and contemporary memories. Using autobiographical reminiscences of her mother's Virginia girlhood a hundred years ago and of her own encounters with that Southern past, she considers how the story of two lost or destroyed objects—a photograph of a house and a portrait of a Southern beauty—help anchor the story of two lives, yet leave it mysteriously open as well.
WHO WAS BADSHAH KHAN?
Authors: Nagler Michael N.
Published: April 2016

Khan Abdul Ghaffar Khan (1890–1988), also called Badshah (“the king”) Khan, is a nearly unknown champion of nonviolence in South Asia and a forgotten Muslim ally of Mohandas Gandhi. The story of Khan's Khudai Khidmatgars (“Servants of God”) movement in what was to become Pakistan is not only inspirational but also instructive, exploding as it does several widespread myths about nonviolence. Today, the United States (with some allies) is embroiled in that region in the longest war in American history and among the Pashtun people from whom Khan arose. Thus his story, according to this article, has a revolutionary potential. When young Malala Yousafzai cited Badshah Khan in a speech at the United Nations in 2013, therefore, she may have done more good than she realized.
CHINESE HISTORICITY
Authors: Pocock J. G. A.
Published: April 2016

This piece is an essay review of Wang Hui's book China from Empire to Nation-State (2014), which is a translation of the introduction to Wang's four-volume Rise of Modern Chinese Thought (2004). According to the reviewer, Wang studies less the modern history of China than its historicity and does so in the context of China's transition from being an empire, inhabiting a cosmos that is the product of its own self-reflection, to being one among a number of nation-states, inhabiting a number of histories of their own, all of which are now simultaneously present. But the Euro-American terms empire and nation-state, which increasingly pervade Chinese perceived realities, lack precise Chinese equivalents. Meanwhile, the terms that the Chinese use in referring to the same historical transition, tianli (“Heavenly Principle”) and gongli (“Universal Principle”), are obscure to the Euro-American mind. The reviewer asks whether the Chinese, now facing a plurality of histories, wonder if there may be a plurality of li (principles), as well, or at least if there can be a li that is “universal” in the sense that it is common to them all. The problem here, the reviewer argues, in part derives from Wang's binaries being Hegelian, while the breakdown of the nation-state in Europe projects a postpolitical order in which human communities are incapable of state-based action or of determining their own li (i.e., Geist). The review ends by questioning whether China is capable of following this path and, in any case, whether Wang's vocabulary is able to encompass it.
Beyond Jews of the Orient: A New Interpretation of the Problematic Relationship between the Thai State and Its Ethnic Chinese Community
Authors: Wongsurawat Wasana
Published: April 2016

“Jews of the Orient,” the infamous and highly polemical article penned by King Vajiravudh Rama VI of Siam and first published in one of the nation's leading newspapers in 1914 has long been employed as the fundamental evidence of the innate anti-Chinese nature of Siam's particular brand of royalist nationalism. The general line of the argument based on the interpretation of Vajiravudh's infamous articles is the king singled out the ethnic Chinese—known to be the largest ethnic minority as well as the dominant force controlling the Siamese economy—as the national other against which Thai nationalism was to be defined and developed. The situation of the ethnic Chinese was not unlike the unfortunate position the Jewish Diaspora found themselves in in Europe in the late nineteenth century to early twentieth century. This line of explanation, however, is not only outdated, but also incorrect in many ways. The proportion of the ethnic Chinese population in Siam is much greater than that of the Jews in Europe and, perhaps more important, the Chinese in Siam were much more closely related to the ruling class. As G. William Skinner had elaborated, even during Vajiravudh's reign, Chinese ancestry made up more than half of the Chakri royal bloodline. In other words, the Chinese were the ruling class in Siam. This article argues that, instead of discriminating against the Chinese, the Siamese ruling classes replaced their Chinese identity with a new Anglicized/Americanized identity, which appeared to be the more modern and influential style of the late nineteenth century to early twentieth century. The Chinese merchants and entrepreneurs who made up most of the Siamese middle class were allowed to keep their Chinese identity provided that they clearly, and oftentimes overtly, expressed their absolute and undivided loyalty toward the crown. The lower-/working-class Chinese either assimilated with the majority or faced persecution for sedition of all sorts—from republicanism and Bolshevism in Vajiravudh's reign to communism during the Cold War years. In reality, the Thai state's relationship with the ethnic Chinese community was more a class issue than a matter of ethnicity and, perhaps more interesting, the state's policy toward the ethnic Chinese changed very little despite the transformation of the state from an absolute monarchy to a constitutional monarchy through the People's Party Revolution of 1932.
A Preliminary Study on Human Placental Tissue Impaired by Gestational Diabetes: A Comparison of Gel-Based versus Gel-Free Proteomics Approaches
Authors: Roverso Marco , Brioschi Maura , Banfi Cristina , Visentin Silvia , Burlina Silvia , Seraglia Roberta , Traldi Pietro , Lapolla Annunziata
Published: April 2016

Gestational diabetes (GDM) is the most common complication of pregnancy and it is associated with maternal and fetal short- and long-term consequences. GDM modifies placental structure and function, but many of the underlying mechanisms are still unclear. The aim of this study is to develop and compare two different methods, based respectively on gel-based and gel-free proteomics, in order to investigate the placental proteome in the absence or in the presence of GDM and to identify, through a comparative approach, possible changes in protein expression due to the GDM condition. Placenta homogenates obtained by pooling six control samples and six samples from GDM pregnant women were analyzed by two-dimensional (2D) electrophoresis coupled with mass spectrometry [nano-liquid chromatography (nano-LC) tandem mass spectrometry (MS/MS) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS)] and by a label-free mass spectrometry method based on LC-MSE. The gel-based approach highlights 13 over-expressed proteins and 16 under-expressed proteins, while the label-free method shows the over-expression of 10 proteins and the under-expression of nine proteins. As regards 2D gel electrophoresis, a comparison between two different protein identification methods, based respectively on nLC-electrospray ionization-MS/MS and MALDI-MS/MS, was performed taking into consideration the sequence coverage, the MASCOT score and the exponentially modified protein abundance index. The analysis of the complex proteome through an integrated strategy revealed that the quantitative gel-free and label-free MS approach might be suitable to identify candidate markers of GDM.
Flip-Flopping, Primary Visibility, and the Selection of Candidates
Authors: Agranov Marina
Published: April 2016

We present an incomplete information model of two-stage elections in which candidates can choose different platforms in primaries and general elections. Voters do not directly observe the chosen platforms, but infer the candidates' ideologies from observing candidates' campaigns. The ability of voters to detect candidates' types depends on the visibility of the race. This model captures two patterns: the post-primary moderation effect, in which candidates pander to the party base during the primary and shift to the center in the general election; and the divisive-primary effect, which refers to the detrimental effect of hard-fought primaries on a party's general-election prospects. (JEL D11, D72, D83)
Separating Bayesian Updating from Non-Probabilistic Reasoning: An Experimental Investigation
Authors: Levin Dan , Peck James , Ivanov Asen
Published: April 2016

Through a series of decision tasks involving colored cards, we provide separate measures of Bayesian updating and non-probabilistic reasoning skills. We apply these measures to (and are the first to study) a common-value Dutch auction. This format is more salient than the strategically equivalent first-price auction and silent Dutch formats in hinting that one should condition one's estimate of the value on having the highest bid. Both Bayesian updating skills and non-probabilistic reasoning skills are shown to help subjects correct for the winner's curse, as does the saliency of the active-clock Dutch format. (JEL D12, D44, D83)
Affirmative Action: One Size Does Not Fit All
Authors: Krishna Kala , Tarasov Alexander
Published: April 2016

This paper identifies a new reason for giving preferences to the disadvantaged using a model of contests. There are two forces at work: the effort effect working against giving preferences and the selection effect working in favor of them. When education is costly and easy to obtain (as in the United States), the selection effect dominates. When education is heavily subsidized and limited in supply (as in India), preferences are welfare reducing. The model also shows that unequal treatment of identical agents can be welfare improving, providing insights into when the counterintuitive policy of rationing educational access to some subgroups is welfare improving. (JEL H52, H75, I23, I28, J15, O15)
Estimated probability of Corporate Bankruptcy by the Example of PJSC «Rostelecom»
Authors: Солтаханов  , Soltakhanov A.
Published: April 2016

Th is article gives a brief overview of the economic situation in Russia in 2014-2015, an analysis was carried

out to determine the fi nancial situation and the probability of bankruptcy of PJSC «Rostelecom» using the most famous

foreign and domestic multifactor models which predict insolvency of the organization.
Biomechanical Rupture Risk Assessment
Authors: Gasser T. Christian
Published: April 2016

Abdominal aortic aneurysm (AAA) rupture is a local event in the aneurysm wall that naturally demands tools to assess the risk for local wall rupture. Consequently, global parameters like the maximum diameter and its expansion over time can only give very rough risk indications; therefore, they frequently fail to predict individual risk for AAA rupture. In contrast, the Biomechanical Rupture Risk Assessment (BRRA) method investigates the wall’s risk for local rupture by quantitatively integrating many known AAA rupture risk factors like female sex, large relative expansion, intraluminal thrombus-related wall weakening, and high blood pressure. The BRRA method is almost 20 years old and has progressed considerably in recent years, it can now potentially enrich the diameter indication for AAA repair. The present paper reviews the current state of the BRRA method by summarizing its key underlying concepts (i.e., geometry modeling, biomechanical simulation, and result interpretation). Specifically, the validity of the underlying model assumptions is critically disused in relation to the intended simulation objective (i.e., a clinical AAA rupture risk assessment). Next, reported clinical BRRA validation studies are summarized, and their clinical relevance is reviewed. The BRRA method is a generic, biomechanics-based approach that provides several interfaces to incorporate information from different research disciplines. As an example, the final section of this review suggests integrating growth aspects to (potentially) further improve BRRA sensitivity and specificity. Despite the fact that no prospective validation studies are reported, a significant and still growing body of validation evidence suggests integrating the BRRA method into the clinical decision-making process (i.e., enriching diameter-based decision-making in AAA patient treatment).
Indications for peripheral, midline and central catheters: summary of the MAGIC recommendations
Authors: Moureau Nancy , Chopra Vineet
Published: April 2016

Patients admitted to acute care frequently require intravenous access to effectively deliver medications and prescribed treatment. For patients with difficult intravenous access, those requiring multiple attempts, those who are obese, or have diabetes or other chronic conditions, determining the vascular access device (VAD) with the lowest risk that best meets the needs of the treatment plan can be confusing. Selection of a VAD should be based on specific indications for that device. In the clinical setting, requests for central venous access devices are frequently precipitated simply by failure to establish peripheral access. Selection of the most appropriate VAD is necessary to avoid the potentially serious complications of infection and/or thrombosis. An international panel of experts convened to establish a guide for indications and appropriate usage for VADs. This publication summarises the work and recommendations of the panel for the Michigan Appropriateness Guide for Intravenous Catheters (MAGIC).
Hot Pressing of Wood-Based Composites: A Review
Authors: Wei Peixing , Rao Xin , Yang Jing , Guo Yeyingzi , Chen Huimin , Zhang Yue , Chen Shihui , Deng Xi , Wang Zheng
Published: April 2016

The hot-pressing process is a vital step in the manufacture of wood-based composites and directly affects the properties and quality of the final products. During hot pressing, the heat and mass transfer process interact with each other, coupling with the mechanical deformation process of wood-based composites under the high-temperature interaction. In addition, the curing of resin, although governed by the laws of chemical reactions, can result in the release or absorption of heat and water, which may, in turn, affect the heat and mass transfer process. Realizing its complex and coupling nature, many scientists have conducted long-term, multisided and multilevel studies to better understand hot pressing. This work reviews the development of wood composite hot pressing, including the heating methods of hot pressing, the mechanism of heat and mass transfer, the hot-pressing models, and the experimental testing of the internal environment. The shortage of current studies and potential directions for future research are also discussed.
Post-Irradiated Human Submandibular Glands Display High Collagen Deposition, Disorganized Cell Junctions, and an Increased Number of Adipocytes
Authors: Nam Kihoon , Maruyama Christina L. , Trump Bryan G. , Buchmann Luke , Hunt Jason P. , Monroe Marcus M. , Baker Olga J.
Published: April 2016

Salivary glands are vital for maintaining oral health. Head and neck radiation therapy is one of the most common causes of salivary gland hypofunction. Little is known about the structural changes that occur in salivary glands after radiation therapy. The aim of this study is to understand the structural changes that occur in post-irradiated human (submandibular gland [SMG]) as compared with untreated ones. We determined changes in epithelial polarity, presence of collagen deposition, and alteration in adipose tissue. We used formalin-fixed paraffin-embedded human SMG from two female subjects exposed to head and neck irradiation. We utilized hematoxylin and eosin staining and Masson’s Trichrome staining. The immunostained tissue sections were examined using confocal microscopy. The number and size of adipocytes per tissue section were calculated using ImageJ, Prism, and SPSS software. Post-irradiated human SMG displayed high collagen deposition, disorganized cell junctions, and an increased number of adipocytes as compared with non-irradiated controls. These findings are important to improve our understanding of the individual risk and variation in radiation-related salivary gland dysfunction.
Aborto por Leptospira en una yegua en Salta, Argentina
Authors: MICHELOUD Juan , MARTÍNEZ M , ZURITA S , GRUNE S , ROMERO G , BRIHUEGA B
Published: April 2016

La leptospirosis en equinos es generalmente asintomática, aunque existen regiones donde la enfermedad constituye un problema. Aquí se describe un caso de aborto en yegua debido a la infección por este agente. Se efectuó la necropsia completa de un feto a término donde se colectaron muestras para inmunofluorescencia directa (IFD), histopatología y microbiología. Además, se efectuó un estudio serológico de la tropilla y se evaluó seroconversión en la yegua abortada. El feto evidenció hepatomegalia, esplenomegalia e ictericia. Microscópicamente se apreció hepatitis mononuclear con disociación de los hepatocitos, esplenitis aguda y glomérulo-nefritis. Aunque el microrganismo no pudo ser aislado, la enfermedad se confirmó por la seroconversión observada en la yegua abortada, y debido a la identificación del agente mediante IFD en la impronta renal. Este caso demuestra la presencia del agente localmente y evidencia que la enfermedad puede ser un problema para la producción ecuestre.
A IMPORTÂNCIA DA PESSOA IDOSA/AVÓS NA EDUCAÇÃO INFANTIL: ESTRATÉGIAS E VIVÊNCIA EXITOSA DE INCLUSÃO
Authors: Barros Leite Salgueiro Cláudia Daniele , De Souza Brito Dias Cristina Maria , Coelho Larissa De Siqueira
Published: April 2016

Este artigo reflete sobre a importância da pessoa idosa no processo de educação pré-escolar e expõe situações exitosas. Analisa questões e fundamentos teóricos relacionados às temáticas dos direitos humanos, inclusão e apoio social. O presente estudo é de caráter qualitativo descritivo e utilizou amostra intencional. O trabalho de campo lançou mão da observação – de inspiração etnográfica e a análise dos dados foi feita por meio de retratos sociológicos. Os resultados evidenciaram que: os pais mostraram-se satisfeitos com a iniciativa da escola; as crianças e os idosos sentiram satisfação em ficar juntos; os educadores alargaram sua compreensão acerca da inclusão do idoso no contexto escolar e puderam ampliar suas atividades. Acredita-se que esta experiência tem implicações importantes em nível das práxis de formação dos educadores, do trabalho realizado com as famílias e das práticas educativas desenvolvidas na educação pré-escolar. http://dx.doi.org/10.14572/nuances.v26i3.3475
DO LETRAMENTO LITERÁRIO À FORMAÇÃO DO ALUNO-AUTOR
Authors: Barbosa Raquel Lazzari Leite , Souza Anderson Ibsen Lopes de
Published: April 2016

O presente artigo visa analisar como atividades didáticas envolvendo a literatura em sala de aula, numa perspectiva de letramento, podem levar o educando ao desenvolvimento de suas capacidades crítica e argumentativa, ou seja, podem contribuir com a formação de seres reflexivos, que apresentem indícios de autoria em suas atividades interlocutivas, que demonstrem autonomia quando do contato com a linguagem. Entendendo que as atividades de reflexão sobre textos literários têm o potencial de formar leitores com papel ativo na relação comunicativa, basear-nos-emos na teoria do letramento literário de Rildo Cosson (2007), buscando compreender como esse processo se dá entre jovens cujo contato com obras literárias fora do ambiente escolar é reduzido ou praticamente nulo, e entender como essa formação cultural influencia na construção textual a partir da organização sintática do código linguístico. http://dx.doi.org/10.14572/nuances.v26i3.3699
COMPREENDER O PASSADO PARA REPENSAR O PRESENTE: A LITERATURA INFANTIL NA HISTÓRIA DA FORMAÇÃO DE PROFESSORES
Authors: Oliveira Fernando Rodrigues de
Published: April 2016

Com os objetivos de compreender a história do ensino da literatura infantil nos cursos de formação de professores e contribuir para o debate sobre as políticas e práticas atuais relacionadas a esse ensino, apresentam-se, mediante pesquisa histórica, aspectos de como foi prescrito o “ensina a ensinar” literatura infantil no estado de São Paulo, entre 1947 e 2003. A institucionalização desse ensino na formação de professores esteve diretamente relacionada à construção de um saber escolar, que encontrou sua sustentação teórica especialmente em conceitos da Psicologia, contribuindo diretamente para a formação de um conceito de literatura infantil ligado ao desenvolvimento psíquico infantil. Com a força de uma “tradição inventada”, esse ensino contribuiu para a construção de um modo específico de dar a conhecer a literatura infantil no Brasil e por subsidiar as relações de ensino referentes a esse gênero literário, ainda identificadas no presente. http://dx.doi.org/10.14572/nuances.v26i3.3703
O PEDAGOGO E A EDUCAÇÃO FÍSICA NO ENSINO FUNDAMENTAL I: DESAFIOS E LIMITAÇÕES DA FORMAÇÃO
Authors: Cândido Cícero Eduardo Souza , Floro Elisângela Ferreira
Published: April 2016

Esta pesquisa fez um estudo dos nove cursos de Pedagogia em funcionamento no Triângulo CRAJUBAR, localidade situada na Região do Cariri Cearense, com o objetivo de analisar o processo de formação dos pedagogos, visto que a Lei n. 11.274/2009 responsabilizou o professor de referência das séries iniciais do Ensino Fundamental I, em geral, um pedagogo por ministrar as aulas de Educação Física. Por isto, propusemo-nos investigar em que aspectos a matriz curricular e as ementas das disciplinas que se referem à Educação Física permitem ao Pedagogo planejar, avaliar e desenvolver aulas de Educação Física que favoreçam o desenvolvimento corpóreo/cognitivo dos estudantes das séries iniciais do Ensino Fundamental I. Trata-se de uma pesquisa básica, de caráter qualitativo, cuja análise se fundamentou na teoria crítico superadora. Os dados coletados foram organizados em categorias, por meio das quais pudemos constatar a ênfase na recreação, em detrimento de uma experiência corporal intergral, ampla e cultural. http://dx.doi.org/10.14572/nuances.v26i3.3722
LITERATURA NA INFÂNCIA: A CRIANÇA, O LIVRO E CAPACIDADE DE LER
Authors: Girotto Cyntia Graziella Guizelim Simões
Published: April 2016

Trata-se de texto base de uma apresentação oral em mesa redonda intitulada “Crianças e jovens, leitores literários” durante o Congresso Internacional de Leitura Infantil e Juvenil: celebrando a leitura, em sua quarta edição(2015), fruto de 20 anos do CELLIJ – Unesp – Presidente Prudente. Nele são discutidas questões relacionadas à educação literária na Infância e a constituição do estatuto leitor, mediante um acesso adequadamente mediado ao livro, articulado às regularidades do desenvolvimento infantil. O debate tematiza a conjugação entre as palavras eleitas para expressar o título: literatura, capacidade de ler, livro e criança.http://dx.doi.org/10.14572/nuances.v26i3.3745
REDES SOCIAIS E O ENSINO: O SKOOB COMO FERRAMENTA PARA O LETRAMENTO DIGITAL E LITERÁRIO
Authors: Burlamaque Fabiane Verardi , Barth Pedro Afonso
Published: April 2016

Neste artigo buscamos refletir sobre o ensino de língua e literatura na contemporaneidade e, para tanto, analisaremos o site Skoob que funciona como uma rede social de leitores e proporemos um diálogo entre os conceitos de letramento digital e letramento literário. A metodologia que permeou este estudo se dá por meio de uma pesquisa bibliográfica com abordagem qualitativa. A principal contribuição do estudo está na reflexão sobre as possibilidades de utilizar a rede social Skoob nas aulas de língua e literatura, uma vez que a escola, no papel de formadora de cidadãos, precisa incorporar práticas relacionadas ao letramento digital e o Skoob pode ser uma ferramenta de auxílio para desenvolver também o letramento literário. http://dx.doi.org/10.14572/nuances.v26i3.3838
Von Hippel-Lindau disease: the clinical manifestations and genetic analysis results of two cases from a single family
Authors: Kinyas S , Ozal SA , Guclu H , Gurlu V , Esgin H , Gurkan H
Published: April 2016

von Hippel-Lindau (VHL) disease is an autosomal dominant inherited multi systemic cancer syndrome that is classically associated with neoplasms in multiple organs, and caused by mutations in the VHL gene on chromosome 3p25-p26. Retinal hemangioblastoma (RH) is the most frequent and the earliest clinical sign of the disease, which is seen in 40.0-60.0% of patients. In recent years, studies of patients with VHL tried to put forward the relationship between genotype and phenotype. In this study, two VHL cases in the same family with clinical findings and genetic analysis results are presented. As a consequence of the genetic studies, a heterozygous missense mutation c.202 T>C, p.S68P (Ser68Pro) in exon 1 of the VHL gene that is mapped to chromosome 3p25.3, was found in the patients’ DNA sample. The germline mutation of [c.202T>C, p.S68P (Ser68Pro)] that was detected in both cases, has been reported in only two cases in the literature. However, in these reported cases, any systemic involvement except RH, were not reported. Although our cases had the same mutation, we detected renal involve-ment in both cases, and also central nervous system (CNS) involvement in one case, in addition to RH.
Modelling of Piezothermoelastic Beam with Fractional Order Derivative
Authors: Kumar Rajneesh , Sharma Poonam
Published: April 2016

This paper deals with the study of transverse vibrations in piezothermoelastic beam resonators with fractional order derivative. The fractional order theory of thermoelasticity developed by Sherief et al. [1] has been used to study the problem. The expressions for frequency shift and damping factor are derived for a thermo micro-electromechanical (MEM) and thermo nano-electromechanical (NEM) beam resonators clamped on one side and free on another. The effect of fractional order derivative on the derived expressions is observed analytically and shown graphically in the case of Lead Zirconate Titanate (PZT)-5A material. For α = 1, our results agree with those that are obtained by Grover and Sharma [20] and other particular cases of interest are also discussed.
Effects of exposure to three environmental chemicals on the selected biochemical parameters of the blood plasma of rainbow trout, Oncorhynchus mykiss (Walbaum)
Authors: Řehulka Jiří , Minařík Bohumil , Machala Miroslav
Published: April 2016

Rainbow trout Oncorhynchus mykiss at a weight of 115 ± 24 g (mean ± SD) were experimentally injected with di(2-ethylhexyl)phthalate (DEHP), 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD) and gamma isomer of hexachlorocyclohexane (γ-HCH ) to evaluate nitrogen metabolism (total protein [TP], blood urea nitrogen, uric acid [UA], creatinine), carbohydrate metabolism (glucose), mineral metabolism (inorganic phosphate[P], total calcium [Cat]), and catalytic activity of enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], lactate dehydrogenase [LD]). After 21 days, the tested xenobiotics, administered by the intraperitoneally route, caused the following effect: in comparison with negative controls, fish injected with DEHP at concentrations of 200 or 50 mg kg-1 of body weight were found to have a higher level of P and lower level of Cat and decreased catalytic concentrations of ALT, AST, ALP and LD in the plasma of the peripheral blood. A higher level of TP and P and a decreased catalytic concentration of ALT were found when TCDD was administered at a dose of 2 μg kg-1. A decrease in the catalytic concentrations of ALT and ALP occurred in fish injected with γ-HCH in a dose of 50 mg kg-1. UA and P levels were decreased in fish injected with γ-HCH in a dose of 5 mg kg-1. DEHP and TCDD caused neutrophilic leucocytosis with a marked left shift. Both concentrations of γ-HCH led to an increase in polychromatophilic erythrocytes. The frequency of micronuclei varied in all experimental groups, including the controls, ranging between 0.8 and 2.1 ‰. Histological examination in fish injected with DEHP at a concentration of 200 mg kg-1 revealed eosinophilic droplets in the epithelium of renal tubules and histological examination in fish injected with γ-HCH at a higher concentration revealed an increased activation of sinusoidal cells in the liver, a fibrous thickening of bile duct walls, bile duct hyperplasia and a periductal inflammatory.
New records of the flat-footed flies (Diptera: Platypezidae) from the Czech Republic and Bohemia
Authors: Tkoč Michal
Published: April 2016

Flat-footed fly (Diptera: Platypezidae) Agathomyia cinerea (Zetterstedt, 1852) is recorded from the Czech Republic for the first time, based on specimens found in the Bukovec Nature Reserve near Jizerka (Kořenov) in the Jizerské hory Mts and Svatý Petr in the Krkonoše Mts. The distribution, seasonal occurrence and habitat preference of this species in Europe are commented. Additionally, two other flat-footed flies, Polyporivora picta (Meigen, 1830) and Seri obscuripennis (Oldenberg, 1916) are recorded for the first time from the territory of Bohemia.
Branding Raw Material to Improve Human Rights: Intel’s Ban on Conflict Minerals
Authors: Osburg Thomas
Published: April 2016

Many companies seek to take over more responsibility for their supply chain and their raw materials. Intel was one of the first companies investigating the origin of conflict minerals like tin, tantalum, gold or tungsten, which are used in many electronic products. Their path to ultimately offering conflict-free microprocessors took more than five years of consistent preparation and intensive reengineering of the business process. They identified smelters as a bottleneck in the supply chain and started cooperating closely with them to trace their minerals’ supply. By developing a bag-and-tag system the company is now able to ensure that their minerals are not sourced from illegal mines, which often finance illegal warlords, for example, in the eastern Democratic Republic of Congo. The cooperation with the smelters brings about higher demand and in consequence higher prices for the legally sourced minerals. Many small miners and their families in the region directly benefit from the higher earnings.
Optimization of Storage Conditions of Malta (Citrus sinensis) Using Response Surface Methodology
Authors: Richa Rishi , Pandey J.P. , Shahi N.C. , Kautkar S.S.
Published: April 2016

Response surface methodology was used to determine the optimum storage conditions of malta fruits that give minimum weight loss and maximum total soluble solid (TSS) retained value. Scavenger (3–5 g), polythene thickness (75–125 gauge) and fungicide concentration (75–200 ppm) were the factors investigated. Experiments were designed according to Box–Behnken design with these three factors, including central points. For each response, a second-order polynomial model was developed using multiple linear regression analysis. Applying desirability function method, optimum storage conditions were found to be 5 g scavenger, 125 gauge polythene thickness and 200 ppm fungicide concentration.
Poeticizing the Psalter in an African Language
Authors: Wendland Ernst R.
Published: April 2016

This study illustrates the application of a literary methodology to the analysis and translation of
biblical poetry. The aim is twofold: first and foundational, to reveal salient aspects of the beauty and power
of Psalm 13 in the original Hebrew; and second, to experiment with different methods of communicating
the original meaning of the psalmist’s passionate prayer with respect to lyric form, content, and function
in Chichewa, a major Bantu language. After a thorough examination of the principal structural and
stylistic features of the biblical text, a typical lament psalm, several published and unpublished Chewa
translations are critically discussed. The ultimate purpose is, as the title of this paper suggests, to produce
an acceptable, functionally equivalent, poetic version of the Hebrew text in the vernacular. In conclusion,
the main principles illustrated in this study are summarized in an effort to encourage more dynamic,
idiomatic, indeed melodic translations of the Scriptures in local languages, where circumstances allow.
“How long” must so many reader-hearers suffer under the burden of a less than communicative version of
the Psalter in their mother tongue?
Theology Without Walls: Sic et Non
Authors: Feldmeier Peter
Published: April 2016

The emerging project, Theology Without Walls, is fascinating and potentially highly fruitful,
particularly given the recognized imperative for doing theology in light of a religiously plural world. But it
is also a project with daunting methodological and philosophical problems. In the first part of the paper,
the author describes why he is attracted to the project and how it might bear theological insight. He also
frames the project along the lines of multiple religious belonging, comparative theology, and the current
cultural zeitgeist. In the second part of the paper, he challenges how such a project would actually work,
given various religions’ diverse and competing metaphysical claims which undergird their theological
principles. Finally, he questions whether such a project would undermine the very purpose of theology for
the kind of public most inclined to being influenced by it. His title’s Sic et Non (Yes and No) refers to both
his commending Theology Without Walls and challenging its viability. He concludes that the collective
weight leads him to challenge the project, at least until it provides a method that satisfactorily addresses
his fundamental concerns.
A ‘No’ at the Core of Life
Authors: Weidenbaum Jonathan
Published: April 2016

The purpose of this essay is to unpack the relevance of William James for the project of a
transreligious theology. While the resources of reason and spiritual experience have long been employed to
arbitrate both within and between different spiritual traditions, I argue that James offers a third principle:
the encouragement of the morally active life, along with a corresponding depiction of the universe in which
our efforts may contribute to the nature of things.
Theology Without Walls: The Future
of Transreligious Theology
Authors: Wildman Wesley J.
Published: April 2016

Transreligious theology is possible. The question we now face concerns how to do it. With that
question in mind, this paper discusses five interpretative angles on transreligious theology, five resources
for transreligious theology, and five challenges facing transreligious theology.
The Breadth of the Riches
Authors: Sydnor Jon Paul
Published: April 2016

Is transreligious theology possible? Yes, but only as a very specific practice. If we accept the
neologism „transreligious“ then we must understand it in contrast with the more traditional terms
„interreligious“ and „comparative“. Interpreted this way, „transreligious theology“ describes religious
discourse about ultimate reality between those with no particular religious identity. Their conversation is
panreligious, treating all theological resources equally, without preference for any tradition over any other
tradition. This conversation will be quite different from interreligious dialogue or comparative theology, in
which participants claim a religious identity while remaining open to the insights of other traditions. Hence,
„transreligious theology“ is a descriptive term rather than a prescriptive method. It is already practiced by
the non-religiously affiliated who hold an interest in the spirituality of all religions. Even though it may
be helpful to some, it is not a necessary practice, since effective theological development can still occur
between those with specific religious identities, and by those who only study their own religious traditions.
Clinical and Pastoral Implications of the
Ministry of Martin Luther and the Protestant
Reformation
Authors: Judd Daniel K.
Published: April 2016

While acknowledging that many theological beliefs and religious practices facilitate mental
health and emotional stability, the major purpose of this paper is to identify and demonstrate that some
of these same beliefs and practices can also contribute to mental instability if understood incorrectly
and practiced unwisely. The unique content of this paper is a pastoral, clinical, and historical narrative
concerning the relationships of religious belief and practice with the mental health of 16th century priest,
pastor, professor, and Protestant reformer Martin Luther. Specifically, this paper discusses Luther’s personal
experiences with mental and emotional instability, including depression and scrupulosity, and explores
ways that discovering and embracing the principle of grace assisted him in dealing with his own mental
and emotional crises. This paper also treats ways that both psychological and theological understanding of
the relationship between the doctrinal principles of grace and human volition can assist both health care
professionals and clergy to provide effective care to those they serve.
Electrocapillary Curves for the Polarisable Liquid–Liquid Interface in Presence of the Peptide Melittin
Authors: Uyanik Ibrahim , Cengeloglu Yunus
Published: April 2016

The adsorption of the anti-microbial peptide melittin at the polarisable water/1,2-DCE (W–DCE) interface is expected to
manifest itself by changes in the interfacial tension. These interfacial tension changes during the peptide adsorption at
the interface were measured by a custom-built quasi-elastic light scattering (QELS) setup. Electrocapillary curves
obtained for melittin at physiological pH evidences the strong affinity of this peptide for the W–DCE interface. In other
words, it is evident that at negative potentials the peptide are readily adsorbed and that at more positive potentials
desorption of adsorbed peptide from the interface proceeds leading to an increase of interfacial tension.
c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea
Authors: Anttonen Tommi , Herranen Anni , Virkkala Jussi , Kirjavainen Anna , Elomaa Pinja , Laos Maarja , Liang Xingqun , Ylikoski Jukka , Behrens Axel , Pirvola Ulla
Published: April 2016

Prevention of auditory hair cell death offers therapeutic potential to rescue hearing. Pharmacological blockade of JNK/c-Jun signaling attenuates injury-induced hair cell loss, but with unsolved mechanisms. We have characterized the c-Jun stress response in the mouse cochlea challenged with acoustic overstimulation and ototoxins, by studying the dynamics of c-Jun N-terminal phosphorylation. It occurred acutely in glial-like supporting cells, inner hair cells, and the cells of the cochlear ion trafficking route, and was rapidly downregulated after exposures. Notably, death-prone outer hair cells lacked c-Jun phosphorylation. As phosphorylation was triggered also by nontraumatic noise levels and none of the cells showing this activation were lost, c-Jun phosphorylation is a biomarker for cochlear stress rather than an indicator of a death-prone fate of hair cells. Preconditioning with a mild noise exposure before a stronger traumatizing noise exposure attenuated the cochlear c-Jun stress response, suggesting that the known protective effect of sound preconditioning on hearing is linked to suppression of c-Jun activation. Finally, mice with mutations in the c-Jun N-terminal phosphoacceptor sites showed partial, but significant, hair cell protection. These data identify the c-Jun stress response as a paracrine mechanism that mediates outer hair cell death.
El proyecto cultural liberador de José Martí para su tiempo y para el siglo xxi
Authors: Escribano Ervis Elmys
Published: April 2016

En el artículo se sostiene la validez y significación del proyecto cultural liberador de José Martí para América Latina. Se analiza desde el momento en que fue concebido a fines del siglo xix y para la actualidad. La determinación y defensa de los puntos de vista que se presentan han sido posibles mediante el análisis de la obra completa de José Martí recogida en los 28 tomos editados en 1963, por la Editorial Nacional de Cuba. El análisis textual de dichas fuentes lo completa su contrastación con el contexto condicionante de las últimas décadas del siglo xix, especialmente en Cuba, México, Guatemala, Venezuela y Estados Unidos, sus contradicciones y tendencias de desarrollo. La exposición del contenido del artículo se ha estructurado en tres apartados: el primero es titulado “América Latina hasta fines del siglo XIX”; el segundo, “José Martí, su conocimiento y vocación latinoamericana”; y el tercero, “El proyecto cultural liberador martiano para América Latina en todos los tiempos”. Se sostiene la idea de la libertad en José Martí como centro vital del proyecto de cambio y desarrollo para América Latina, en la que vertebró coherentemente su discurso cultural al que se integra la educación, la ciencia, la prensa y el arte, en distintas manifestaciones.
Humanidades digitales: la censura y los laudatorios en las preliminares del Siglo de Oro español; Madrid y Guzmán de Alfarache
Authors: Becerra Mayorga Witton , Camacho Machado Joice
Published: April 2016

Este artículo presenta los resultados del estudio de la censura y los laudatorios en algunas preliminares de la literatura del Siglo de Oro español. Fue realizado con la metodología de “queries” en la plataforma Sylvadb del Laboratorio Culturplex. El trabajo se divide en cuatro partes: introducción, donde se definen los elementos teóricos desde los cuales se aborda la investigación; metodología, en la que se tratan los pasos de la investigación desde la lectura, la elaboración de la base de datos, las consultas (searchs) y preguntas (queries); resultados, en los cuales se indican los resultados obtenidos de la investigación, y por último están las conclusiones, que señalan dos asuntos que aportan nuevas propuestas al campo de los estudios literarios respecto a las humanidades digitales y al trabajo sobre las preliminares.
A solução apresentada por R. M. Hare para os problemas do emotivismo e do descritivismo em filosofia moral
Authors: Oliveira Anselmo Carvalho de
Published: April 2016

Na primeira parte, argumento que o descritivismo proposto por Moritz Schlick não compreende adequadamente a função dos juízos morais. Na segunda parte, argumen-to que o emotivismo não apresenta uma explicação adequada para o papel da razão na ética. Na terceira parte, argumento que o prescritivismo universal proposto por R. M. Hare avança na solução dos problemas do emotivismo, porque amplia o papel da razão na ética, e na solução dos problemas do descritivismo, porque compreende a função dos juízos morais na linguagem ordinária.