bluuebunny/crossref_metadata_2025 huggingface dataset:
Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina
Authors: Donval Alicia , Hernandez Puente Cinthia Violeta , Lainé Anaïs , Roman Diana , Vessely Romain , Leclercq Julien , Perron Muriel , Locker Morgane
Published: December 2023

A growing wealth of data suggest that reactive oxygen species (ROS) signalling might be crucial in conferring embryonic or adult stem cells their specific properties. However, how stem cells control ROS production and scavenging, and how ROS in turn contribute to stemness, remain poorly understood. Using the Xenopus retina as a model system, we first investigated the redox status of retinal stem cells (RSCs). We discovered that they exhibit higher ROS levels compared with progenitors and retinal neurons, and express a set of specific redox genes. We next addressed the question of ROS functional involvement in these cells. Using pharmacological or genetic tools, we demonstrate that inhibition of NADPH oxidase-dependent ROS production increases the proportion of quiescent RSCs. Surprisingly, this is accompanied by an apparent acceleration of the mean division speed within the remaining proliferating pool. Our data further unveil that such impact on RSC cell cycling is achieved by modulation of the Wnt/Hedgehog signalling balance. Altogether, we highlight that RSCs exhibit distinctive redox characteristics and exploit NADPH oxidase signalling to limit quiescence and fine-tune their proliferation rate.
Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis
Authors: Pei Fei , Ma Li , Guo Tingwei , Zhang Mingyi , Jing Junjun , Wen Quan , Feng Jifan , Lei Jie , He Jinzhi , Janečková Eva , Ho Thach-Vu , Chen Jian-Fu , Chai Yang
Published: December 2023

Nerves play important roles in organ development and tissue homeostasis. Stem/progenitor cells differentiate into different cell lineages responsible for building the craniofacial organs. The mechanism by which nerves regulate stem/progenitor cell behavior in organ morphogenesis has not yet been comprehensively explored. Here, we use tooth root development in mouse as a model to investigate how sensory nerves regulate organogenesis. We show that sensory nerve fibers are enriched in the dental papilla at the initiation of tooth root development. Through single cell RNA-sequencing analysis of the trigeminal ganglion and developing molar, we reveal several signaling pathways that connect the sensory nerve with the developing molar, of which FGF signaling appears to be one of the important regulators. Fgfr2 is expressed in the progenitor cells during tooth root development. Loss of FGF signaling leads to shortened roots with compromised proliferation and differentiation of progenitor cells. Furthermore, Hh signaling is impaired in Gli1-CreER;Fgfr2fl/fl mice. Modulation of Hh signaling rescues the tooth root defects in these mice. Collectively, our findings elucidate the nerve-progenitor crosstalk and reveal the molecular mechanism of the FGF-SHH signaling cascade during tooth root morphogenesis.
Longitudinal Changes in Quadriceps Morphology over the First Three Months Following Anterior Cruciate Ligament Reconstruction
Authors: Johnston Christopher D. , Dewig Derek R. , Pietrosimone Brian , Padua Darin , Ryan Eric D. , Hart Joe , Spang Jeffrey , Blackburn Troy
Published: December 2023

Purpose

Neuromuscular deficits and atrophy following anterior cruciate ligament reconstruction (ACLR) may be accompanied by changes in muscle composition and poor quadriceps muscle quality (QMQ). Quadriceps atrophy occurs following ACLR, but improves within the first three post-operative months, yet this hypertrophy could be attributable to increases in non-contractile tissue (i.e. poor QMQ). The purposes of this study were to evaluate changes in QMQ following ACLR and determine if changes in QMQ and cross-sectional area (CSA) occur in parallel or independently.

Methods

A longitudinal prospective cohort design was implemented to evaluate QMQ and CSA in 20 individuals with ACLR and 12 healthy controls. Participants completed three testing sessions (baseline/pre-surgery, 1 month, and 3 months) during which ultrasound images were obtained from the vastus lateralis (VL) and rectus femoris (RF). QMQ was calculated as the echo intensity (EI) of each image, with high EI representing poorer QMQ. Anatomical CSA was also obtained from each image.

Results

RF and VL EI were greater at 1 and 3 months in the ACLR limb compared to baseline and the contralateral limb, and did not change between 1 and 3 months. VL and RF CSA in the ACLR limb were smaller at 1 and 3 months compared to the contralateral limb and controls (VL only), but increased from 1 to 3 months. Changes in QMQ and CSA were not correlated.

Conclusions

QMQ declines within the first month following ACLR and does not improve by 3 months even though hypertrophy occurs, suggesting that these morphological characteristics change independently following ACLR. Poorer QMQ represents greater concentration of noncontractile tissues within the muscle and potentially contributes to chronic quadriceps dysfunction observed following ACLR.
Device-Measured Physical Activity in 3,506 Individuals with Knee or Hip Arthroplasty
Authors: Small Scott R. , Khalid Sara , Price Andrew J. , Doherty Aiden
Published: December 2023

Purpose

Hip and knee arthroplasty aims to reduce joint pain and increase functional mobility in patients with osteoarthritis; however, the degree to which arthroplasty is associated with higher physical activity is unclear. The current study sought to assess the association of hip and knee arthroplasty with objectively measured physical activity.

Methods

This cross-sectional study analysed wrist-worn accelerometer data collected in 2013-2016 from UK Biobank participants (aged 43-78). Multivariable linear regression was performed to assess step count, cadence, overall acceleration, and activity behaviours between non-arthritic controls, end-stage arthritic, and postoperative cohorts, controlling for demographic and behavioural confounders. From a cohort of 94,707 participants with valid accelerometer wear time and complete self-reported data, electronic health records were used to identify 3,506 participants having undergone primary or revision hip or knee arthroplasty and 68,389 non-arthritic controls.

Results

End-stage hip or knee arthritis was associated with taking 1,129 fewer steps/day [95% CI: 811, 1,447] (p < 0.001), and having 5.8 fewer minutes/day [95% CI: 3.0, 8.7] (p < 0.001) of moderate-to-vigorous activity compared to non-arthritic controls. Unilateral primary hip and knee arthroplasty were associated with 877 [95% CI: 284, 1,471] (p = 0.004) and 893 [95% CI: 232, 1,554] (p = 0.008) more steps than end-stage osteoarthritic participants, respectively. Postoperative unilateral hip arthroplasty participants demonstrated levels of moderate-to-vigorous physical activity and daily step count equivalent to non-arthritic controls. No difference in physical activity was observed between any cohorts in terms of overall acceleration, or time spent in daily light activity, sedentary behaviour, or sleep.

Conclusions

Hip and knee arthroplasty are associated with higher levels of physical activity compared to participants with end-stage arthritis. Unilateral hip arthroplasty patients, in particular, demonstrate equivalence to non-arthritic peers at more than 1 year following surgery.
Effect of comprehensive nursing intervention on quality of life and treatment outcomes in elderly patients with Gout and Hyperuricemia complicated with hypertension
Authors: Liu Jing , Lu Na , Shen Shilu , Zhang Wen
Published: December 2023

Objective: To evaluate the effect of comprehensive nursing intervention on the quality of life and treatment outcomes of elderly patients with gout and hyperuricemia complicated with hypertension.

Methods: This is a clinical comparative study. One hundred and twenty elderly patients with gout and hyperuricemia complicated with hypertension who were hospitalized at Baoding No.1 Central Hospital were included from March 20, 2021 to March 20, 2022, and randomly divided into two groups. Patients in the control group were given conventional nursing care in the perioperative period, while those in the experimental group were given comprehensive nursing intervention on the basis of the control group. The differences between the two groups in terms of clinical effects, quality of life were compared and analyzed.

Results: The response rate of the experimental group was higher than control group,with a statistically significant difference. After the intervention, the above indicators improved significantly in the experimental group compared to the control group, with statistically significant differences. There was no significant difference in Self-Rating Anxiety Scale(SAS) and Self-rating depression scale(SDS) levels between the two groups before the intervention. After the intervention, SAS and SDS decreased significantly in the experimental group compared to the control group, with statistically significant differences . The patient satisfaction rate of the experimental group was also higher than control group, with a statistically significant difference.

Conclusion: Comprehensive nursing intervention is an effective treatment option for elderly patients with gout and hyperuricemia complicated with hypertension, resulting in obvious improvements in patient quality of life, improved mood, patient satisfaction and treatment outcomes.

doi: https://doi.org/10.12669/pjms.40.3.7535

How to cite this: Liu J, Lu N, Shen S, Zhang W. Effect of comprehensive nursing intervention on quality of life and treatment outcomes in elderly patients with Gout and Hyperuricemia complicated with hypertension. Pak J Med Sci. 2024;40(3):---------.  doi: https://doi.org/10.12669/pjms.40.3.7535

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Μορφές τουριστικής ανάπτυξης στη σύγχρονη Ελλάδα
Authors: Σπυρόπουλος Ιωάννης
Published: December 2023

Η υπόθεση ότι ο τουρισμός αποτελεί ένα συνεχώς εξελισσόμενο φαινόμενο ως αποτέλεσμα ευρύτερων σύνθετων κοινωνικών, πολιτισμικών, τεχνολογικών, πολιτικών και οικονομικών αλλαγών, δημιουργούν στην εθνική τουριστική νομοθεσία, την ανάγκη συχνών αναμορφώσεων. Στο πλαίσιο της προαναφερθείσας υπόθεσης, διαμορφώνεται, την τελευταία δεκαετία, στην Ελλάδα, μια νέα και συνεχώς μεταβαλλόμενη τουριστική πολιτική και ένα νέο πρότυπο χωρικής οργάνωσης, ως προϊόντα των μεταβολών που συμβαίνουν στο εσωτερικό και διεθνές περιβάλλον του τουρισμού. Αναλυτικότερα, διαμορφώνονται στην Ελλάδα, ειδικά τουριστικά προϊόντα και νέες μορφές χωρικής οργάνωσης της τουριστικής ανάπτυξης (εν προκειμένω: από τη μία, ανάπτυξη σε Οργανωμένους Υποδοχείς Τουριστικών Δραστηριοτήτων (ΟΥΤΔ), καθοδηγούμενη από το αντίστοιχο θεσμικό πλαίσιο, στην οποία κυριαρχούν τα Σύνθετα Τουριστικά Καταλύματα (ΣΤΚ) και οι τουριστικές κατοικίες, και από την άλλη, διάχυτη και «αυθόρμητη» ανάπτυξη της οικονομίας διαμοιρασμού, απουσία κανονιστικού πλαισίου, με κύριο εκφραστή τα ακίνητα βραχυχρόνιας μίσθωσης), οι οποίες εκφράζονται και συνυπάρχουν στις περιοχές της χώρας με ένα αδιευκρίνιστο προς το παρόν τρόπο και διακρίνονται για την χωρική τους υπόσταση. Η έρευνα με αφετηρία, λοιπόν, τις παραπάνω διαπιστώσεις επιχειρεί να συμβάλλει στη περαιτέρω διερεύνηση της ανάπτυξης των μορφών τουριστικής δραστηριότητας στην σύγχρονη Ελλάδα, όπως αυτή διαμορφώνεται μέσω των ΟΥΤΔ, ΣΤΚ, τουριστικών κατοικιών και ακινήτων βραχυχρόνιας μίσθωσης της οικονομίας διαμοιρασμού. Με αυτό τον στόχο και μέσω της ανάδειξης του μεγέθους των υπό διερεύνηση μορφών και της αναζήτησης και αξιολόγησης των προοπτικών, καθώς και των ανασταλτικών παραγόντων, που ενέχουν οι προαναφερθείσες τουριστικές επενδυτικές πρωτοβουλίες στη βιώσιμη και υπεύθυνη τουριστική ανάπτυξη της χώρας, επιχειρείται να αναδυθούν, επιπρόσθετα, οι αρχές και οι προϋποθέσεις ενσωμάτωσης αυτών των μορφών, στο πλαίσιο μιας πολυδιάστατης και ολοκληρωμένης προσέγγισης της τουριστικής δραστηριότητας στην Ελλάδα. Τέλος, η έρευνα επιχειρεί να εμβαθύνει στον τρόπο με τον οποίο μπορεί να ανατροφοδοτηθεί ο υφιστάμενος χωρικός και τουριστικός σχεδιασμός ώστε να συμβάλει, αφενός στην περαιτέρω ενίσχυση της ανταγωνιστικότητας του τουριστικού προϊόντος της χώρας με όρους αειφορίας, και αφετέρου στην αντιμετώπιση των χρόνιων παθογενειών της ελληνικής τουριστικής ανάπτυξης.
Αισθητική και αρχιτεκτονικές αξίες στο "μη αρχιτεκτονημένο" βιομηχανικό ερείπιο
Authors: Καλλέα Σοφία
Published: December 2023

Πρόθεση της διατριβής είναι η διερεύνηση ενός μη καταγεγραμμένου τμήματος βιομηχανικών κτιριακών καταλοίπων και του τοπίου που τα περιβάλλει. Πρόκειται για τα ανενεργά, εγκαταλελειμμένα λατομεία της περιόδου 1950-1980 (ή και προγενέστερα σε ορισμένες περιπτώσεις). Η διερεύνηση αυτή έχει διττή στόχευση: - Η πρώτη, με καταγραφικό χαρακτήρα, επιχειρεί μέσω επιτόπιας έρευνας, καταρχήν να εντοπίσει τους λατομικούς χώρους και, ακολούθως να αποτυπώσει τις ερειπωμένες εγκαταστάσεις επεξεργασίας πετρωμάτων που λειτούργησαν εκεί.-Η δεύτερη φιλοδοξεί να ιχνηλατήσει τα ποιοτικά εκείνα χαρακτηριστικά των τελευταίων που στοιχειοθετούν και εξηγούν την ακούσια ανάδυση αισθητικών και αρχιτεκτονικών αξιών. Η υιοθετηθείσα μεθοδολογία στηρίχθηκε –κατ’ αντιστοιχία με τη διττή φύση της στόχευσης– σε δύο επιχειρησιακούς πόλους: -Ο πρώτος περιλαμβάνει όλες τις διαδικασίες που αφορούν στην πρωτογενή έρευνα πεδίου: αρχικά, πραγματοποίηση ταξιδιών στο χερσαίο τμήμα της ελληνικής επικράτειας, εντοπισμός ανενεργών λατομικών εγκαταστάσεων της προαναφερθείσας περιόδου, σχεδιαστική και φωτογραφική τους αποτύπωση, καθώς και χρονολογική τους τεκμηρίωση μέσω αναζήτησης και σύγκρισης υποβάθρων (χάρτες-αεροφωτογραφίες της περιόδου 1950-1980). -Ο δεύτερος επιστρατεύει στοχαστικούς τρόπους, ερμηνευτικές ατραπούς και θεωρητικά εργαλεία με τα οποία το αντικείμενο της μελέτης μπορεί να θεωρηθεί κριτικά, με την προσοχή εστιασμένη όχι πια στη λειτουργική του φύση (εκείνη δηλαδή που απορρέει από την πρακτική αναγκαιότητα) αλλά, τώρα, στραμμένη προς τις πτυχές του εκείνες όπου διακρίνονται να υποφώσκουν συνθήκες, έννοιες, υλικές και άυλες ποιότητες που άπτονται άμεσα ενός αρχιτεκτονικού και αισθητικού ενδιαφέροντος.
First genetic survey on the invasive rayed pearl oyster Pinctada radiata (Leach, 1814) populations of the Balearic Islands (Western Mediterranean)
Authors: AGUILO-ARCE JOSEBA , FERRAGUT F. JOANA , PNG-GONZALEZ LYDIA , CARBONELL AINA , CAPA MARÍA
Published: December 2023

A survey of the invasive pearl oyster Pinctada radiata along the Balearic Archipelago was conducted based on the COI mitochondrial marker. Results confirmed the identity of the specimens as P. radiata. The Balearic populations are certainly of Indo-Pacific origin but not from the Persian Gulf nor from other introduced populations in the eastern or central Mediterranean, therefore the precise origin remains to be discovered. Despite the small number of samples from the Persian Gulf compared to the Mediterranean, the haplotype diversity is higher in the native populations compared to the non-native.
Ρυθμός και μουσικότητα στα προφορικά παιδικά ποιήματα και τραγούδια. Από το πλαίσιο της άτυπης εκπαίδευσης σε σύγχρονες διδακτικές προεκτάσεις.
Authors: Κόκκινος Δημήτρης Εμμανουήλ , Κολιάδη-Τηλιακού Ανθούλα
Published: December 2023

Τα παιδικά ποιήματα/τραγούδια της λαϊκής προφορικής παράδοσης αποτελούν μία μορφή διαχρονικής και οικουμενικής πολιτισμικής δημιουργίας που απασχολεί, εκτός από τους τομείς της εθνογραφικής έρευνας και των λαογραφικών σπουδών, κι εκείνους της παιδαγωγικής επιστήμης, της γλωσσολογίας και της μουσικολογίας. Η παρούσα μελέτη, βασιζόμενη σε ευρήματα της βιβλιογραφικής επισκόπησης, εστιάζει το ενδιαφέρον της στη σημασία και τον ρόλο που παίζει ο ρυθμός ως πρωτογενές στοιχείο των παιδικών ποιημάτων/τραγουδιών της λαϊκής προφορικής παράδοσης. Τα πορίσματα της μελέτης μέσα από παραδείγματα διαφορετικών γλωσσών, με έμφαση σε εκείνα της Ελληνικής, επιβεβαιώνουν την ύπαρξη ενός παγκόσμιου κοινού κώδικα που συνδέει οργανικά δυο πρωτογενή στοιχεία της προφορικής ποιητικής των παιδιών τα οποία απαντώνται σε καθολικό επίπεδο και συνιστούν οικουμενικά χαρακτηριστικά: τον ρυθμό και τη μουσικότητα. Ο περίφημος «παιδικός ρυθμός», όπως τον αποκάλεσε ο Ρουμάνος εθνομουσικολόγος C. Brailoiu, ο οποίος και τον ανέδειξε πρώτος, είναι ένας δυαδικός ρυθμός που βασίζεται σε σειρές που διαρκούν όσο οκτώ  κτυπήματα ή οκτώ σύντομες συλλαβές. Η επιτέλεσή του στο πλαίσιο της προφορικότητας του προσδίδει έναν αυθόρμητο, βιωματικό και κιναισθητικό χαρακτήρα με ποικίλες παιδαγωγικές προεκτάσεις. Η ύπαρξη του παιδικού ρυθμού έχει κατά καιρούς απασχολήσει αρκετούς θεωρητικούς (Α. Arleo, Β. De Cornulier, S. Baud-Bovy) τόσο από γλωσσική όσο και από μουσικολογική άποψη. Η διερεύνηση και αποτύπωση του πολυδιάστατου χαρακτήρα της παιδικής προφορικής ποίησης παρέχει ικανά ερεθίσματα για περαιτέρω αξιοποίησή της στην εκπαιδευτική διαδικασία, καθώς δύναται να την εμπλουτίσει με παιδαγωγικό υλικό και πρακτικές που συμβάλλουν στη γλωσσική, μουσική, και εν γένει πολιτισμική και κοινωνική καλλιέργεια των παιδιών.
The impact of a therapy dog program on children’s with ASD social skills, communication, and behavioral difficulties
Authors: Karpoutzaki Chrysoula , Markodimitraki Maria , Kypriotaki Maria , Charitaki Garyfalia
Published: December 2023

Recent research findings confirm the mediating role of animals, especially dogs, between a therapist and a child during therapy sessions. The presence of dogs has been studied in clinical studies. In cases of children with disabilities dogs facilitate the therapeutic session as they distract children from their real problems and make them feel relaxed. However, there is a research gap on the impact of a therapy dog in a school setting. The present study aims to explore the effectiveness of therapy dogs’ presence in an intervention programme for students with Autism Spectrum Disorder (ASD). Three primary school students with ASD, their teachers and parents, and a therapy dog with its attendant were enrolled in the study. Data collection was based on teachers’ and parents’ observations of students’ social responses and behavioural difficulties before and after the intervention, on teachers’ diaries, and on the micro-analysis of the six videotaped therapeutic sessions. Results show that the dog’s presence increased student response to social stimuli and reduced the symptoms of ASD, not only during the intervention but also in the post-intervention phase. No aggressive or self-injurious behaviours were exhibited during the sessions.  The study highlights the healing impact for children with ASD when a dog is incorporated in a school setting.
DEVELOPMENT OF SOFTWARE FOR THE GROUP LOCALIZATION OF PHRASES IN THE DATABASE
Authors: Gareeva Gulnara A. , Khamidullin Marat R. , Nurutdinov Riyaz R. , Shaikhutdinov Rinas Y.
Published: December 2023

When creating modern cars, in addition to analog and mechanical devices, digital technologies are also very widely used.

The article considers the process of software development for group unloading of text phrases into a database in the C# programming language and using Windows Presentation Framework, which is reasonable to apply to facilitate the tasks of developing car diagnostics procedures.

The goal is to development of software for group uploading of text phrases to a database in the C# programming language and using the Windows Presentation Framework (WPF).

The method or methodology of the work: the article discusses a project to develop a WPF application for group uploading of text phrases to a database.

Results: a program with a UI interface has been developed to automate the unloading of phrases into the database.

Scope of the results: the obtained results should be used to facilitate the tasks of developing car diagnostic procedures.
ASSESSMENT OF THE UNEVENNESS OF THE MOVEMENT OF VEHICLES IN THE PLACES OF SEPARATION OF TRAFFIC FLOWS
Authors: Borodulin Igor V. , Gasilova Olga S. , Maltseva Anastasia A. , Sidorov Boris A.
Published: December 2023

The movement of vehicles in the places of separation of traffic flows is analyzed. The high-speed mode of movement of vehicles along traffic lanes at a regulated intersection in the places of traffic flow separation has been determined. It is recorded that the number of formed “bundles” increases in the places of separation of transport flows. The movement of the formed “packs” of moving cars determines the speed mode of vehicles. The experiment showed that the speed of movement along the lanes is different. In a lane with a large number of formed “bundles”, the speed of cars is less than in a lane with a smaller number of “bundles”. It is established that the presence of “bundles”, especially in the areas of separation of traffic flows, leads to a large variation in the range of changes in the speed of vehicles at the intersection. The highest value of the speed mode of vehicles when driving on the experimental section is within 15-20 km/h, and the lowest is less than 5 km/h.

Purpose – determination of the factors influencing the change in the speed regime of vehicles in the places of separation of traffic flows.

Methodology statistical methods of processing a full-scale experiment were used in the work.

Results: the ranges of changes in the speed of vehicles in places where traffic flows are separated by lanes and the reasons for their changes are determined.

Practical implications: the obtained results should be used in the development of measures to ensure road safety in places of separation of traffic flows and the organization of traffic at intersections.
ANALYSIS OF ROUTING PROTOCOLS EFFECTIVENESS IN COMPUTER NETWORKS
Authors: Avetisyan Tatiana V. , Lvovich Yakov E. , Lvovich Igor Ya. , Blinov Roman A.
Published: December 2023

The main task of networks is to transport information from the sending computer to the receiving computer. In most cases, you need to make several transfers to do this. The problem of choosing a path is solved by routing algorithms. The routing algorithm must have well-defined properties: reliability, correctness, stability, simplicity and optimality. The latter property is not as transparent as it may seem at first glance, it all depends on which or which parameters are optimized. This task is sometimes not at all easy even for relatively simple local networks. Optimization parameters may include minimum delivery delay, maximum throughput, minimum price, maximum reliability, or minimum error probability. In this paper, reactive, proactive and hybrid routing protocols are considered. When making their choice, we relied on the method of hierarchy analysis. Based on the results obtained during the simulation of a network with video conference traffic, a matrix was constructed for each of the criteria studied. The protocols were compared in terms of the possibility of information loss. The results of the research can be useful in the course of building modern computer networks.
Integration of Sustainable Development Principles into the Corporate Strategy of State-Owned Companies: Development of an Eff ective System for Disclosing ESG Factors in Reporting
Authors: Mamedova S.
Published: December 2023

This article explores the integration of sustainable development principles into the corporate strategy of state-owned enterprises. The primary focus is on developing an effective system for disclosing ESG-factors (Environmental, Social and Governance) in corporate reporting. Th e article explores the advantages and challenges of integrating ESG-factors into corporate strategy, along with recommendations for optimal approaches to disclosure and consideration of these factors in reporting.
Project Activity in an Educational Institution of Secondary Vocational Education
Authors: Romanchenko M. , Filippov B.
Published: December 2023

The article discusses the possibilities of forming professional competencies when performing a diploma project in educational institutions of secondary vocational education through the involvement of students in project activities. The substantiation of the approach to the design activity of the pedagogical worker is proposed, the procedural scheme of the design of the educational process in the implementation of the diploma project is proposed. The role of project activity in achieving educational goals, as well as the impact on the professional development of the student is shown. The conducted studies allow us to conclude that it is necessary to divide the design process into stages that differ in priority deterministic goals. The structure of the professional module, made on the basis of the federal state standard in the system of secondary vocational education, is given.
Human rights and modern international relations
Authors: Kartashkin Vladimir
Published: December 2023

The collection contains scientific articles published mainly in the period from 2021 to 2023.
The articles included in the collection explore current problems, modern achievements and shortcomings of international relations, as well as contain specific proposals by the author to improve cooperation between states in the field of human rights in the process of transition to a new stage of development — international protection of human rights.
For students, undergraduates, postgraduates and for anyone interested in international law and human rights issues.
Development of a simulation model of the influence of communication with users on management and decision-making to assess the investment attractiveness of the region
Authors: Soldatova Mariya
Published: December 2023

Communication with users is of great importance for management and decision-making in assessing the investment attractiveness of the region. Most app users have little interest in updates to the financial situation of the regions or the adoption of new laws on subsidizing the regions. To better inform users, applications use various forms of notifications. Many Russian companies are considering the use of direct communication with users and most of them choose the communication channel – email. Informing about important changes via email is most convenient for users due to its conciseness and unobtrusiveness of the solution. The article presents the results of a study of the impact of sending email notifications on the investment activity of users of the application for assessing the investment attractiveness of the regions of the Russian Federation. From this study, conclusions were drawn that information based on the results of assessing the investment attractiveness of regions will become more widespread and popular, which will allow a greater number of private investors to participate in investment projects in the regions. If the application sends updated information on the investment attractiveness of the regions of the Russian Federation, new provisions in legislation and subsidies, this will increase private investment activity.
Prácticas no laborales de calidad: coordenadas a partir de la Resolución del Parlamento Europeo de 14 de junio de 2023.
Authors: Bini Stefano
Published: December 2023

El presente Estudio pretende abordar algunos aspectos de la regulación del complejo y multifacético tema de las prácticas no laborales en entornos profesionales, centrando la atención en la Resolución del Parlamento Europeo de 14 de junio de 2023, con recomendaciones destinadas a la Comisión sobre períodos de prácticas de calidad en la Unión.
Rekolekcje internowanych w stanie wojennym
Authors: Dróżdż Andrzej
Published: December 2023

Wiara w Boga i bliski związek z Kościołem utwierdzały internowanych działaczy opozycji antykomunistycznej w przekonaniu, że doczekają Polski sprawiedliwej, demokratycznej, suwerennej i opartej na trwałych wartościach moralnych. Rekolekcje były dla nich zbieraniem sił, okazją do uporządkowania zarówno własnego życia, jak i planów działania na rzecz wspólnego dobra. Książka, którą przekazujemy Czytelnikowi, wyróżnia się na tle innych tego typu publikacji z serii Pokolenie Solidarności niezwykłą możliwością przesłuchania siedmiu godzin oryginalnych nagrań, dokonanych w trzech ośrodkach odosobnienia przez duszpasterzy internowanych. Są wśród nich homilie ks. Władysława Palmowskiego i o. Pawła Mynarza Cist., wygłaszane z pasją i odwagą, są przesłania internowanych mężczyzn do załóg zakładów pracy i działających w podziemiu członków „Solidarności”, są oryginalne słuchowiska poetycko-muzyczne, a zwłaszcza pieśni i piosenki, układane przez uwięzionych. Książka ta jest ważnym dokumentem epoki, skierowanym zwłaszcza do młodego pokolenia Polaków, aby nie zapominało o tamtych czasach.
Contest Schemes and Dynamic Incentive Provision
Authors: Fan Qintao , Johnson Nicole
Published: December 2023

Simple contest schemes, which tend to use extreme contemporaneous peer benchmarking, are generally thought to be less efficient at motivating productive and cooperative effort than explicit bonus contracts that optimally weight observed own and peer outputs. We show, however, that contest schemes can outperform explicit bonus contracts in a two-period dynamic setting if periodic output is correlated over time, and contract terms can be renegotiated. In our model, all parties update their beliefs about ex ante unknown time-invariant noise upon observing first-period outputs, and second-period wage offers are updated accordingly. This creates first-period shirking incentives for the agents. We show that relative to bonus contracts, the extreme contemporaneous peer benchmarking in contest schemes can weaken or even eliminate the adverse incentives created by prior-period benchmarking, even though the available information and the learning process are the same under both schemes. This dynamic advantage allows contest schemes to outperform repeated bonus contracts for a wide range of parameter values, despite imposing higher static efficiency losses in each period. If competing agents are assigned to sufficiently similar tasks, a contest scheme’s ability to sever the statistical link between periods can yield not only higher early productive effort compared with bonus contracts, but also less uncooperative behavior, despite putting the agents in a more contest-like situation.

This paper was accepted by Brian Bushee, accounting.

Supplemental Material: The online appendices are available at https://doi.org/10.1287/mnsc.2022.00035 .
CIBERCULTURA E O ENSINO SUPERIOR: EXPERIÊNCIAS DOCENTES COM/NO ENSINO REMOTO EMERGENCIAL
Authors: Mancio Geidy Dalia da Costa , Vale-Silva Priscila
Published: December 2023

A Covid-19, pandemia iniciada em 2020, no Brasil, trouxe inúmeras mudanças sociais, sobretudo para a esfera escolar. Professores substituíram o espaço físico pelo espaço virtual, o que demandou habilidades para lidar com diferentes tecnologias, resultando assim na ampliação de letramentos digitais.  Diante disso, mais do que nunca, o tema cibercultura revestiu-se de fundamental importância, pois se inseriu nas práticas pedagógicas docentes. Partindo desse contexto, apresentamos uma investigação realizada com nove professores do curso de Pedagogia da Universidade do Estado do Rio Grande do Norte, campus Avançado de Assú, objetivando descrever e analisar práticas de letramentos desenvolvidas pelos docentes no contexto da cibercultura, durante o período do ensino remoto emergencial. Fundamentamos a pesquisa em estudos que tratam a cibercultura como um conjunto de atividades desenvolvidas em espaços virtuais e que demandam diferentes tipos de letramentos, sobretudo os letramentos digitais. Assumimos a abordagem qualitativa e o estudo de caso para os procedimentos de geração de dados, que teve como instrumento um questionário online. Os resultados indicam que a maioria dos professores tinha domínio de algumas ferramentas tecnológicas e conheciam os suportes para utilizá-las, mas sentiam dificuldades para fazer uso dessas tecnologias com o novo formato de ensino. Verificamos que houve uma busca por formações continuadas em tecnologias digitais voltadas para o ensino e concluímos que o formato de ensino remoto emergencial possibilitou aos professores ampliar suas práticas de letramentos digitais, em benefício das suas práticas pedagógicas, além de favorecer a interação com os alunos no processo de ensino-aprendizagem no contexto da cibercultura.
Contato pele a pele em um centro de referência do Método Canguru: estudo descritivo
Authors: Delgado Bruna Schiphorst , Costa Roberta , Souza Janaina Medeiros de , Pina Juliana Coelho , Azevedo Vívian Mara Gonçalves de Oliveira , Almeida Débora Evelin Felix Quirino de
Published: December 2023

Objetivo: descrever como ocorre a prática do contato pele a pele em uma unidade neonatal referência para o Método Canguru. Método: estudo descritivo, transversal, realizado em unidade intensiva neonatal do sul do Brasil. Dados analisados por meio de estatística descritiva simples. Protocolo aprovado pelo Comitê de Ética em Pesquisa. Resultados: analisados dados de 29 recém-nascidos pré-termo, com peso menor de 1.800 gramas. O primeiro contato pele a pele foi realizado, em média, com 6,38 dias. A frequência de contato pele a pele foi de 1,6 vezes ao dia, sendo o tempo mínimo de 56 minutos e o ganho ponderal médio de 26,98 gramas por dia. Conclusão: a realização do contato pele a pele acontece, em sua maioria, após o quinto dia de vida, na primeira etapa do Método. A frequência de realização deste contato foi de uma vez por dia e o tempo de duração médio foi de 120 minutos. Na segunda etapa do Método, os dados pouco variaram.
Tendência de mortalidade prematura por doenças crônicas não transmissíveis no estado de São Paulo
Authors: Pereira Helena Nayara Santos , Uehara Sílvia Carla da Silva André
Published: December 2023

Objetivo: analisar a tendência de óbitos prematuros relacionados às doenças crônicas não transmissíveis e sua relação com o nível de escolaridade e renda da população do estado de São Paulo. Método: estudo ecológico, utilizando dados do Departamento de Informática do Sistema Único de Saúde (DATASUS), referentes aos óbitos registrados no período de 2012 a 2019, de pessoas na faixa etária de 30 a 69 anos em decorrência de doenças cardiovasculares e respiratórias; neoplasias e diabetes mellitus. Os dados foram analisados por meio de modelo linear generalizado de distribuição binomial-negativa com função de ligação logarítmica Resultados: o coeficiente de mortalidade prematura por doenças crônicas não transmissíveis apresentou aumento, passando de 313,16 óbitos/ 100.000 habitantes no ano de 2012 para 315,08/100.000 habitantes em 2019. Conclusão: há necessidade de uma atenção especial da gestão em saúde às doenças crônicas não transmissíveis, ações para a prevenção, promoção e diagnóstico precoce, destacando-se o papel relevante dos serviços da atenção primária à saúde.
Administração de anti-infecciosos em pacientes críticos: gestão proativa de riscos
Authors: Castro Alaíde Francisca de , Rodrigues Maria Cristina Soares
Published: December 2023

Objetivo: analisar a gestão de riscos proativa do processo de administração de anti-infecciosos em Unidade de Terapia Intensiva. Método: estudo qualitativo, em pesquisa-ação, com observação participante e grupo focal, realizado de 2019 a 2021. Foi mapeado o processo, analisados os riscos, planejadas ações de melhorias e redesenhado o processo. Resultados: a prescrição ocorria em sistema eletrônico e os registros da administração em impressos. O processo de administração de anti-infecciosos possuía 19 atividades, dois subprocessos, 16 modos de falhas e 23 causas potenciais. Os modos de falhas foram relacionados à assepsia e erro de dose no preparo de anti-infecciosos e as causas apontadas foram a falha humana na violação das técnicas e o lapso de memória. Cinco especialistas redesenharam o processo resultando em alterações de atividades e no sistema. Conclusão: a gestão de riscos proativa aplicada ao processo de administração de anti-infecciosos propiciou identificar riscos, suas causas e priorizar ações de melhorias, o que pode viabilizar tomadas de decisões apropriadas.
Diversity, inclusivity and widening participation: VN Futures campaigns 2023
Authors: Pace Charlotte
Published: December 2023

The VN Diversity, Inclusion and Widening Participation Working Group seeks to actively promote diversity and inclusivity for those considering a career in veterinary nursing, while also addressing the support needed by those from diverse backgrounds who are already working in the profession. This article looks at the campaigns that have taken place in 2023.
Rehabilitation following surgical management of canine osteoarthritis
Authors: Corral Cheryl
Published: December 2023

A multimodal approach is often considered best for the successful management of canine osteoarthritis. While most cases of mild or moderate osteoarthritis can be managed well without surgical intervention, surgery should be considered as a treatment option for severe cases that are not responding well to conservative management alone. The surgical options available for the patient vary depending on a number of factors such as the individual joint(s) worse affected, and the age and size of the patient. Rehabilitation is indicated following surgery in order to maximise patient outcome regardless of the procedure; and is likely to be beneficial longer term in order to continue to manage the clinical signs associated with osteoarthritis.
The Main Genome is a Source of Adaptogens and the Basis for the Development of a New Vaccination Technology
Authors: Vladyko A.S. , Petkevich A.S.
Published: December 2023

The appearance of viruses in mammals and plants is provoked by environmental factors - xenobiotics, formed mainly due to unreasonable human activity and resulting from the formation of an ecological (epidemiological) niche filled with molecular motifs of the microbiota - the intestines of mammals and the root system of plants.  To do this, bacteria and archaea use retrovirus-like “cut and paste” mechanisms, including, for example, the CRISPR/Cas system, when the molecular motifs of the microbiota try to adapt the immune and hormonal systems. It all depends on how much xenobiotics damage the immune and hormonal systems. Therefore, viruses are not the cause, but the consequence of the disease. The fight against viruses with the help of vaccines prepared on their basis has been violating and restraining the natural mechanisms of regulation of biological processes in plants and mammals. Thus, molecular motifs arising from microbiota bacteria become either apaptogens (viruses) or adaptogens. In the first and second cases, genetic information is released into the environment. In the latter case, there is an adaptation or a kind of vaccination of others by a natural mechanism. This mechanism is also applicable to somatic diseases, such as cardiovascular, autoimmune, oncological, etc. As for the original properties of coronaviruses, it is their ability to suppress innate and acquired nonspecific viral immunity in the respiratory tract. This leads to the reactivation of chronic, mainly bacterial, respiratory infections - pneumococci, staphylococci, hemophiluses, however, fungal infections can also be observed – mucormycosis, aspergillosis, etc. This feature of the virus prompted doctors at the beginning of the epidemic (2020) to use a pneumococcal vaccine, which, as it turned out, similarly to the coronavirus vaccine reduces the severity of the disease and mortality. As for the diagnosis of coronavirus infection and its treatment, as practice has shown, everything depends on the stage of the disease, starting with a viral and ending with a bacterial infection. Similar and identical antigenic determinants in coronavirus and respiratory group bacteria often caused confusion when analyzing the results of serological and molecular biological diagnostic tests in patients with COVID-19. Moreover, the justified use of antibiotics in the post-viral, that is, in bacterial periods, made it possible to successfully treat patients with a positive PCR test for coronavirus on an outpatient basis.
Functional outcome of routine versus on-demand removal of the syndesmotic screw
Authors: van den Heuvel Stein , Penning Diederick , Sanders Fay , van Veen Ruben , Sosef Nico , van Dijkman Bart , Schepers Tim
Published: December 2023

Aims

The primary aim of this study was to present the mid-term follow-up of a multicentre randomized controlled trial (RCT) which compared the functional outcome following routine removal (RR) to the outcome following on-demand removal (ODR) of the syndesmotic screw (SS).

Methods

All patients included in the ‘ROutine vs on DEmand removal Of the syndesmotic screw’ (RODEO) trial received the Olerud-Molander Ankle Score (OMAS), American Orthopaedic Foot and Ankle Hindfoot Score (AOFAS), Foot and Ankle Outcome Score (FAOS), and EuroQol five-dimension questionnaire (EQ-5D). Out of the 152 patients, 109 (71.7%) completed the mid-term follow-up questionnaire and were included in this study (53 treated with RR and 56 with ODR). Median follow-up was 50 months (interquartile range 43.0 to 56.0) since the initial surgical treatment of the acute syndesmotic injury. The primary outcome of this study consisted of the OMAS scores of the two groups.

Results

The median OMAS score was 85.0 for patients treated with RR, and 90.0 for patients treated with ODR (p = 0.384), indicating no significant difference between ODR and RR. The secondary outcome measures included the AOFAS (88.0 in the RR group and 90.0 for ODR; p = 0.722), FAOS (87.5 in the RR group and 92.9 for ODR; p = 0.399), and EQ-5D (0.87 in the RR group and 0.96 for ODR; p = 0.092).

Conclusion

This study demonstrated no functional difference comparing ODR to RR in syndesmotic injuries at a four year follow-up period, which supports the results of the primary RODEO trial. ODR should be the standard practice after syndesmotic screw fixation.

Cite this article: Bone Jt Open 2023;4(12):957–963.
A Quantitative Model to Characterize and Measure Granular Flow Behavior and Grain Layer Mixing
Authors: Tenboer Heather H. , Mosher Gretchen Ann , Hurburgh Charles R.
Published: December 2023

Abstract.

Highlights

Introduction of a practical model for evaluating granular flow behavior.

Results show that in-bin behavior of granular flow is consistent regardless of flow amount.

Implications for traceability and recall of bulk products are addressed.

Food quality and safety concerns have led to the national and global implementation of regulation and legislation focused on food and feed practices. The food and feed industry also benefit from traceability tools because data collected from such systems are useful as metrics for internal decision making. Bulk commodity grain traceability systems are challenging because most shipments are aggregated mixtures of grain from multiple sources. The amount of mixing that occurs due to the layering of grain and the flow regimes present as grain is removed has not been previously quantified. This lack of certainty on where specific lots are located leads to costly and inefficient recalls. This experiment is the first step in developing an understanding of how much mixing is occurring in grain storage bins to better predict flow regimes for traceability purposes. Accordingly, a small model similar in structure to a flat-floored cylindrical grain bin was designed to test grain flow. The experimental model presented consistent flow behavior data that aligned with expected regimes for flat-floored structures across 30 replications. These outcomes suggest that grain bin mixing and flow remain consistent regardless of flow amount. The data also provide the basis for the development of a probability model. Keywords: Bulk grain, Food security, Grain traceability, Granular flow, Grain mixing, Traceability systems.
Design of a Distance Measuring System for Sugarcane Collection and Transfer Vehicle Based on Mutation Numerical Feature Extraction and Processing
Authors: Wen Chunming , Wu Wanling , Yan Yunzhi , Hou Bingxu , Cui Wenxuan , Huang Youzong , Li Kaihua , Long Xiaozhu , Nong Hongliang , Lu Yuchun , Lan Zimian
Published: December 2023

Highlights

Maintaining the appropriate distance between two vehicles can effectively reduce the loss of sugarcane harvesting.

The data processing method of numerical mutation feature extraction combined with sliding mean filtering can effectively filter out the interference from the sugarcane field environment on the distance measurement.

The distance measurement system has been successfully constructed and applied to practical work, and the average relative error of distance measurement is 0.05%.

Abstract. To improve the automation of the whole stalk sugarcane combine harvester and reduce the work intensity of the driver of the sugarcane collection and transfer vehicle, a sugarcane field collection and transfer vehicle that follows a ranging system was independently designed in this article. Then, a data processing method that extracts the numerical mutation features and combines the sliding mean filtering of the fluctuation characteristics of the ranging data in rugged and hilly land was proposed. First, frequency modulated continuous wave (FMCW) radar was used to measure the distance between two vehicles. The effects of the travel speed and shaking angle on the ranging accuracy were analyzed according to the working environment. The results showed that they have significant effects on the ranging results. Second, the abnormal data were identified and replaced using numerical mutation features, and then sliding mean filtering was applied to the replaced overall data. Finally, the system was implemented in an experiment in the field, and the results showed that the ranging accuracy of the system was significantly improved. The average relative error was reduced from 0.12% to 0.05%, and the ranging stability was good. Keywords: FMCW radar, Numerical feature extraction, Ranging system, Sliding mean filtering, Sugarcane collection and transportation.
Chemical and Physical Properties of Organic Bedding Materials
Authors: Spiehs Mindy , Woodbury Bryan L. , Brown-Brandl Tami M.
Published: December 2023

Highlights

Finely ground particles absorb more water than medium or coarse particles.

Corn stover and wheat straw have highest water holding capacity and a moderate rate of evaporative water loss.

Corn cobs absorb the least amount of water but retain the water longer than other bedding materials.

Corn stover, wheat straw, and soybean stover have highest fertilizer value.

Considering all characteristics, wheat straw, corn stover, and soybean stover are the most favorable materials to use in livestock housing systems.

Abstract. Physical and chemical characteristics of organic bedding materials determine how well they will absorb and retain moisture and may influence the environment in livestock facilities where bedding is used. The objective of this study was to determine water holding capacity (WHC) and rate of evaporative water loss (EWL) of organic materials used as bedding in livestock facilities. Corn stover, soybean stover, wheat straw, switch grass, paper, corn cobs, and wood (pine and cedar) were evaluated; coarse, medium, and fine particle sizes of each bedding material were measured. The WHC was determined by submerging bedding materials in permeable nylon bags for 1, 3, 5, 10, 20, and 30 min, and 1, 3, 6, 9, 12, 24, 48, and 72 h. Generally, finely ground particles had higher WHC (P < 0.05) than the medium or coarsely ground particles of the same material. Corn stover (3.2 g g-1) and wheat straw (3.3 g g-1) had the highest WHC. Switch grass, dry cedar, green cedar, and corn cobs (1.4, 1.5, 1.6 and 1.9 g g-1, respectively) absorbed the least amount of water. Corn cobs retained water the longest when EWL was measured at 100°C, 25°C, and 15°C (6.0, 33.0, and 38.1 days, respectively). Based on N, P, and K content, corn stover, wheat straw, and soybean stover bedding had the highest fertilizer value of the bedding materials studied. Considering all characteristics, wheat straw, corn stover, and soybean stover are the most favorable bedding materials to use in livestock housing systems. Keywords: Bulk density, Corn stover, Evaporative water loss, Soybean stover, Switch grass, Water holding capacity, Wheat straw, Wood chips.