bluuebunny/crossref_metadata_2025 huggingface dataset:
Over-the-Counter Hearing Aids Versus Traditional Hearing Aids in Patients With Mild-to-Moderate Hearing Loss: Protocol for a Noninferiority Randomized Controlled Trial (Preprint)
Authors: Kim Ga-Young , Jo Mini , Cho Young Sang , Moon Il Joon
Published: October 2024

BACKGROUND

With the aging of society, the prevalence of hearing loss (HL) is increasing. Currently, approximately 5% of the global population has HL, and this number is projected to reach 7 million by 2050. Although hearing aids (HAs) are the primary treatment for HL, their use is limited by barriers such as high costs and social stigma. To address these limitations, over-the-counter (OTC) HAs have been introduced, but their effectiveness and drawbacks require further investigation.

OBJECTIVE

This study aims to conduct a noninferiority randomized controlled trial comparing OTC HAs with traditional HAs to assess the clinical effectiveness of OTC HAs.

METHODS

We designed a noninferiority randomized controlled trial comparing OTC HAs and traditional HAs in adults with mild-to-moderate HL. A total of 64 participants (32 per group) will be recruited. Randomization will be performed using block randomization (block sizes of 2 or 4) with an equal allocation ratio. The study will include 2 types of HAs: an OTC HA (Jabra Enhance Pro) and a traditional HA (LiNX Quattro LE561-DRW) by GN ReSound A/S. OTC HAs will be self-fitted using a smartphone app, while traditional HAs will be fitted by a licensed audiologist using the National Acoustics Laboratories–Non-Linear Prescription, second generation. Assessments, including functional gain, real-ear measurement, speech audiometry, and questionnaires, will be conducted at 6-month intervals over the course of 3 visits. Statistical analysis will compare the 2 outcomes, focusing on functional gain, to determine noninferiority.

RESULTS

This study is scheduled to begin in August 2024 and has not yet recruited any participants. The study will be conducted over 2 years, from August 2024 to July 2026. Each participant will have 2 follow-up visits at 6-month intervals, making the total follow-up period 1 year.

CONCLUSIONS

Since 2022, the introduction of OTC HAs has revolutionized access to these devices. Researchers, clinicians, and the general public are keen to evaluate the clinical effectiveness of OTC HAs, as more individuals will likely use them for HL. This increased usage will provide valuable real-world data to understand the benefits and limitations of OTC HAs. Monitoring the outcomes and user feedback will provide insights into their effectiveness and impact on hearing rehabilitation.

CLINICALTRIAL

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/59894
Screening and Risk Analysis of Atrial Fibrillation after Radiotherapy for Breast Cancer: Protocol for a Cross-Sectional Cohort Study (Watch Your HeaRT – WATCH study) (Preprint)
Authors: Saint-Lary Laura , Pinel Baptiste , Panh Loic , Jimenez Gaelle , Geffrelot Julien , Kirova Youlia , Camilleri Jeremy , Broggio David , Bernier Marie-Odile , Mandin Corinne , Levy Christelle , Boveda Serge , Thariat Juliette , Jacob Sophie
Published: October 2024

BACKGROUND

Post-radiotherapy atrial fibrillation (AF) in breast cancer (BC) patients is a relatively new and understudied topic. AF can increase the risk of stroke and other serious cardiovascular complications, compromising patients' quality of life and survival. Detection of AF, both asymptomatic and symptomatic forms, is therefore essential for optimal management.

OBJECTIVE

The aim of the WATCH study is to assess the incidence of AF (symptomatic or asymptomatic) occurring throughout a 5-years follow-up after RT and to investigate whether cardiac radiation exposure is associated with the occurrence of such events.

METHODS

WATCH is a cohort study that will include 200 patients over 65 years old, treated with radiotherapy for BC five years before inclusion, without history of AF. Cross-sectional screening for AF at the time of the scheduled five-year post-radiotherapy visit is conducted by recording data from a Withings ScanWatch smartwatch for one month, confirmed by an ECG, and validated by a physician. In addition, a transthoracic echocardiography is performed, providing comprehensive assessment of cardiac structures, and allowing to investigate underlying etiology and assess the risk of complications. Patient's medical record provides retrospective information on the timing and risk factors for the occurrence of AF and other arrhythmias and cardiac diseases during the 5 years following RT. The development of deep learning algorithms for auto-segmentation analysis of potentially critical sub-structures for the occurrence of AF, including cardiac chambers, sinoatrial node, atrioventricular node, coronary arteries, pulmonary veins, will produce dosimetry linked to previous radiotherapy treatment for all contoured structures.

RESULTS

The inclusions started in October 2023 and will continue until mid-2026 to include 200 patients. The results are expected by the end of 2026.

CONCLUSIONS

This study will contribute to generating new knowledge on AF after radiotherapy for BC, and help considering AF screening into routine clinical practice in these patients. Identifying the dose-risk associations would improve RT delivery protocols to limit the occurrence of these arrhythmias and, if necessary, initiate appropriate treatment.

CLINICALTRIAL

ClinicalTrials.gov:NCT06073509. Registration date: 10/09/2023
Dampak Penundaan Jadwal Kemoterapi Terhadap Rekurensi Pada Pasien Kanker payudara
Authors: Mukrinin Walit Uhkri , Nurrochmad Arief , Rahmawati Fita
Published: October 2024

Kemoterapi merupakan modalitas pengobatan utama pada kanker payudara bersama dengan operasi dan radioterapi. Kemoterapi memberikan manfaat dalam peningkatan ketahanan hidup pasien, namun manfaat tersebut dipengaruhi oleh kepatuhan terhadap jadwal kemoterapi. Dampak prognostik negatif dari keterlambatan dosis kemoterapi ini dapat berpengaruh pada hasil ketahanan hidup. Tujuan dari penelitian ini adalah untuk mengetahui gambaran penundaan jadwal kemoterapi (alasan dan durasi penundaan) serta dampaknya terhadap rekurensi. Penelitian ini menggunakan desain kohort retrospektif, melibatkan 138 pasien wanita kanker payudara stadium awal (stadium I-IIB) yang mendapatkan kemoterapi. Ekposur dalam penelitian adalah penundaan jadwal kemoterapi dan durasi penundaan, sedangkan luaran penelitian adalah rekurensi kanker payudara. Data penelitian diperoleh dari rekam medik pasien di RSUP Dr. Sardjito Yogyakarta. Analisis penelitian menggunakan metode Chi-square, Kaplan-Meier serta Cox-regression untuk mengetahui Hazard Ratio dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa penundaan jadwal kemoterapi pada pasien kanker payudara berhubungan dengan meningkatkan resiko rekurensi (HR 4,718; 95% Cl: 1,533-14,520, log rank tes p=0,003). Sementara durasi penundaan jadwal kemoterapi ≤7 hari dan >7 hari tidak berhubungan dengan peningkatan resiko rekurensi (HR 1,001; 95% Cl: 0.307-3,260, log rank tes p=0,999). Keterlibatan farmasi klinis sangat diperlukan untuk mencegah dan menyelesaikan masalah terkait efek samping obat serta monitoring pengobatan sehingga luaran pengobatan menjadi optimal.
Gambaran Terapi dan Luaran Klinik Bedaquiline Pada Pasien MDR TB di RSUP Dr Kariadi Semarang
Authors: Puspitasari Niken , Puspitasari Ika , Nuryastuti Titik
Published: October 2024

Tuberkulosis (TB) merupakan penyakit infeksi penyebab kematian terbanyak di dunia. Bedaquiline adalah antimikroba baru yang mempunyai aktivitas spesifik melawan Mycobacterium tuberculosis. Tujuan penelitian ini untuk mengetahui gambaran terapi dan luaran klinik Bedaquiline pada pasien MDR TB di RSUP Dr Kariadi Semarang. Subyek penelitian yaitu pasien MDR TB di RSUP Dr. Kariadi Semarang periode 1 Januari 2017 sampai dengan 31 Juli 2021. Analisis data dilakukan secara deskriptif menggunakan metode univariat meliputi data karakteristik subyek, gambaran penggunaan obat, luaran klinik pasien. Terdapat 125 pasien MDR TB yang memenuhi kriteria inklusi dan eksklusi. Rata-rata usia pasien 46,6 tahun ± 13,1 tahun; 57,6% merupakan laki-laki; 53,6% berpendidikan SMA; 67,2% pasien mempunyai pekerjaan; 8,2% pasien berstatus menikah; dan 88,0% pasien mempunyai IMT normal. Jenis obat tuberkulosis yang paling banyak digunakan bersamaan dalam regimen mengandung Bedaquiline yaitu Clofazimin (87,2%), Cycloserin dan Ethambutol (82,4%), Pyrazinamid (80,8%), Isoniazid (69,6%), Ethionamid (65,6%), Levofloxacin (64,8%) dan Linezolid (48,8%). Pasien mengalami konversi kultur sputum rata-rata 52,2 hari dengan SD 42 hari. Tingkat keberhasilan terapi mencapai 74,4% (pasien sembuh 73,6% dan pengobatan lengkap 0,8%). Pasien yang meninggal dunia sebanyak 18 pasien (14,4%); putus berobat 8 pasien (6,4%); dan gagal pengobatan 6 pasien (4,8%).
Narrative Review: Efektivitas Sitikolin vs Asam Folat dalam Menurunkan Disabilitas Neurologis Pasien Stroke Iskemik Akut
Authors: Purwandityo Ayuningtyas Galuh , Ikawati Zullies , Pinzon Rizaldy Taslim
Published: October 2024

Stroke adalah penyebab kedua kematian di seluruh dunia serta menyebabkan disabilitas fisik dan neurologis jangka panjang. Keparahan defisit neurologis dini adalah penentu yang paling penting dari hasil fungsional akhir pada stroke iskemik akut. Tujuan dari penelitian ini adalah membandingkan efektivitas penggunaan sitikolin dan asam folat dalam memperbaiki disabilitas neurologis pasien stroke iskemik akut. Penelitian ini dilakukan dengan cara narrative review dan dilakukan dalam empat tahap yaitu penentuan kata kunci, kriteria inklusi dan eksklusi, seleksi literatur, dan analisis hasil. Pencarian literatur dilakukan melalui database elektronik seperti PubMed, Scopus, Science Direct, Wiley Online Library dan Springer Link. Berdasarkan review yang dilakukan diperoleh data bahwa sitikolin terbukti neuroprotektor yang aman dan efektif diberikan pra, pasca serta pengobatan stroke jangka panjang sebab mampu menurunkan disabilitias neurologis. Pada penggunaan asam folat juga cenderung terbukti efektif untuk mencegah stroke, namun biasanya dikombinasi dengan vitamin B12 atau vitamin B6. Selain itu, data terkait fungsi asam folat dalam menurunkan disabilitas neurologis pasca stroke atau sebagai pengobatan jangka panjang masih sangat terbatas.
Karakteristik Klinis dan Profil Terapi Pasien Rawat Inap COVID-19 di Rumah Sakit Akademik Universitas Gadjah Mada Yogyakarta Periode Maret – Agustus 2020
Authors: Maturbongs Graciano Aristides , Ikawati Zullies , Yasin Nanang Munif
Published: October 2024

Coronavirus Disease (COVID-19) muncul sebagai sebuah pandemi yang menjadi masalah kesehatan global. Terapi untuk mengobati COVID-19 hingga saat ini masih berkembang dinamis. Penelitian ini bertujuan untuk memberikan gambaran karakteristik, regimen terapi, dan luaran pasien COVID-19 yang dirawat pada periode Maret – Agustus 2020 di Rumah Sakit Akademik Universitas Gadjah Mada Yogyakarta. Penelitian ini merupakan penelitian deskriptif dengan rancangan serial kasus yang dilakukan secara retrospektif. Jumlah pasien yang memenuhi kriteria inklusi adalah 24 pasien dengan 18 pasien laki-laki dan 6 pasien perempuan. Derajat keparahan pasien COVID-19 dalam penelitian ini terdiri dari tanpa gejala (25%), ringan (37,5%), sedang (29,2%), dan berat (8,3%). Batuk merupakan gejala yang paling banyak dialami oleh pasien (62,5%) diikuti demam (37,5%). Gejala lain yang juga dialami oleh pasien antara lain sesak (16,7%), pilek (12,5%), pusing (8,3%), sakit tenggorokan (8,3%), mual (8,3%), dan myalgia (11,1%). Data laboratorium menunjukkan nilai hitung leukosit dan limfosit cenderung normal namun nilai NLR cenderung meningkat. Regimen terapi yang diperoleh pasien adalah adalah antibiotik (91,7%), antivirus (4,2%), hidroksiklorokuin/klorokuin (75%), kortikosteroid (12,5%), antikoagulan (16,7%), suplemen (100%). Lama rawat inap semua pasien dalam penelitian ini adalah 9-15 hari dengan status luaran klinis pasien sembuh sebesar 20,8% dan membaik sebesar 79,2%.
Perancangan Desain Model Management Inventory System Apotek
Authors: Doko Karmelia Intany , Kristina Susi Ari , Lazuardi Lutfan
Published: October 2024

Salah satu standar pelayanan kefarmasian di apotek adalah pengelolaan obat dan dapat dijadikan indikator mutu pelayanan kefarmasian di apotek. Sistem informasi merupakan salah satu faktor pendukung kefektifan dan efisiensi pengelolaan obat. Sistem informasi manajemen (SIM) saat ini terbatas pada pencatatan dan pelaporan proses operasional yang ada di apotek dan belum ada fitur tambahan dalam pengelolaan obat di apotek. Penelitian ini bertujuan untuk membuat model sistem informasi manajemen pengendalian persediaan obat melalui pendekatan user centered design (UCD). Penelitian ini merupakan deskriprif yaitu analisis kebutuhan pengguna menggunakan metode focus group discussion (FGD) dan observasi. Prototype didesain dapat berinteraksi langsung ke pengguna untuk dapat dilakukan perancangan lanjutan. Subyek penelitian ini berjumlah 10 orang yang terdiri dari 5 orang pemilik sarana apotek (PSA) dan 5 orang apoteker. Kebutuhan data dalam pengelolaan obat di apotek meliputi data barang, data satuan, data supplier, data penerimaan dan penjualan, data inkaso, data barang rusak dan kadaluarsa, data usulab obat baru, data pengadaan dan data stock opname. Desain sistem pengelolaan obat yang dibuat merupakan desain dalam bentuk data flow diagram (DFD). Kesimpulan penelitian ini adalah perlu dibuat desain model lanjutan pengelolaan obat yaitu entity relationship diagram (ERD), data dictionary, dan data dummy sehingga akan menghasilkan prototype sistem informasi yang bisa berjalan tanpa adanya error pada sistem.
Hubungan Tingkat Pengetahuan dan Kepatuhan Pasien Hipertensi di Apotek di Yogyakarta
Authors: Supadmi Woro , Sary Mega Indah , Gailea Astrimulyana , Monica Lia , Saputri Ginanjar Zukhruf , Hastuti Dwi
Published: October 2024

Jumlah penderita hipertensi tahun 2021 di Daerah Istimewa Yogyakarta mencapai 251.100 kasus. Jumlah pasien yang sudah mendapat pelayanan kesehatan 129.420 kasus (51,5%). Pengetahuan tentang obat hipertensi dapat berpengaruh terhadap kepatuhan penggunaan obat. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dengan kepatuhan pada pasien hipertensi di Apotek di Yogyakarta. Rancangan penelitian ini adalah cross-sectional dengan pengambilan data secara prospektif pada Maret-April 2023. Jumlah sampel di tentukan dengan rumus Lameshow. Sampel diambil dengan menggunakan teknik non-probability sampling dengan metode purposive sampling sesuai kriteria inklusi. Pengumpulan data meliputi karakteristik pasien, data penggunaan obat, pengetahuan menggunakan kuesioner dan kepatuhan kuesioner MARS. Data dianalisis secara univariat dan biavariat untuk mengetahui hubungan tingkat pengetahuan dan kepatuhan. Hasil penelitian yang dilakukan dengan 200 pasien didapatkan hasil tingkat pengetahuan tinggi 68,0% dan kepatuhan patuh 80,0%. Hasil uji menggunakan uji chi-square dan kolerasi Spearman diperoleh p-value<0,05, koefisien kolerasi 1,000. Hal ini menunjukkan bahwa adanya hubungan sangat kuat antara tingkat pengetahuan dan kepatuhan pasien hipertensi di Apotek di Yogyakarta. Terdapat hubungan sangat kuat antara tingkat pengetahuan dengan kepatuhan terapi pada pasien hipertensi di Apotek di Yogyakarta.
Gambaran Efektivitas Terapi Antiretroviral Paduan Rejimen TLD (Tenofovir + Lamivudin+ Dolutegravir) pada Pasien HIV di RSUP Dr. Mohammad Hoesin Palembang
Authors: Susanti Diah , Nuryastuti Titik , Ikawati Zullies
Published: October 2024

Dolutegravir (DTG) merupakan obat Antiretroviral (ARV) golongan integrase inhibitor (INSTI) terbaru yang pada tahun 2019 World Health Organization (WHO) merekomendasikannya sebagai pilihan terapi ARV lini pertama dan kedua pada pasien Human Immunodeficiency Virus (HIV). Di Indonesia, DTG direkomendasikan pada Juli 2020 sebagai penyempurna pedoman rejimen ARV. Tujuan penelitian ini untuk mengetahui gambaran efektivitas terapi ARV paduan rejimen TLD (Tenofovir + Lamivudin + Dolutegravir) yang merupakan rejimen pilihan dan alternatif baru pada pasien HIV di RSUP Dr. Mohammad Hoesin Palembang. Analisis data dilakukan secara deskriptif dengan rancangan kohort retrospektif, menggunakan statistik univariat meliputi data karakteristik subjek dan efektivitas terapi ARV paduan rejimen TLD. Sampel penelitian ini terdiri dari 100 pasien HIV yang mulai menggunakan terapi ARV selama periode 1 April 2020 sampai dengan 30 September 2021. Kriteria inklusi dalam penelitian ini adalah pasien HIV baru yang mendapat terapi ARV paduan rejimen TLD dan berusia ≥18 tahun, sedangkan kriteria eksklusi adalah pasien HIV yang menggunakan terapi ARV paduan rejimen TLD mengganti paduan rejimen sebelum enam bulan terapi. Pasien HIV yang menggunakan paduan rejimen TLD pada penelitian ini lebih banyak berjenis kelamin laki-laki (77%), berusia produktif 20-49 tahun (89%), berpendidikan lulusan SLTA (51,8%), bekerja (68,9%), sudah menikah (48,5%) dan berasal dari luar kota Palembang (55%). Saat awal terdiagnosa HIV, pasien paling banyak pada stadium klinis satu (36,4%), status fungsional kerja (61%) dan ada infeksi oportunistik (61%). Hasil dari pemeriksaan viral load dan CD4 setelah enam bulan terapi yaitu lebih banyak pasien yang viral load < 200 kopi/ml (93,8%) dan kadar CD4 ≥ 200 mm3/sel (66,7%), hal ini menunjukkan bahwa terapi TLD efektif berdasarkan dari respon virologis dan imunologis yang baik. Namun dari hasil analisis hubungan karakteristik dengan viral load dan CD4, nilai P > 0,05 yang artinya karakteristik pasien tidak berpengaruh signifikan terhadap hasil viral load dan CD4 setelah enam bulan terapi.
Persepsi Pengguna terhadap Keberhasilan Implementasi SIMRS di Rawat Inap Rumah Sakit Santo Borromeus
Authors: Susanti Eni , Lazuardi Lutfan , Satibi Satibi
Published: October 2024

Sistem Informasi Manajemen Rumah Sakit (SIMRS) terintegrasi di Rumah Sakit Santo Borromeus telah diterapkan sejak tahun 2019. Implementasi SIMRS ini sudah banyak dirasakan manfaatnya, namun masih ditemui permasalahan. Penelitian ini bertujuan untuk mendapatkan gambaran keberhasilan implementasi SIMRS di rawat inap RS Santo Borromeus. Jenis penelitian ini adalah deskriptif kuantitatif dengan desain cross sectional. Teknik pengumpulan data dengan survei melalui kuesioner. Populasi penelitian adalah seluruh pegawai RS Santo Borromeus dengan kriteria inklusi adalah petugas rumah sakit yang memiliki hak akses terhadap penggunaan SIMRS dan secara langsung menggunakan SIMRS di rawat inap dalam menunjang pekerjaan sehari-hari. Kriteria eksklusi adalah petugas rumah sakit yang tidak bersedia dilibatkan dalam penelitian dan dengan masa kerja kurang dari 1 tahun. Teknik pengumpulan data dengan proportionate stratified random sampling, sebanyak 204 responden terlibat dalam penelitian ini. Analisis data dilakukan secara deskriptif dengan cara menjelaskan destribusi prosentase dan rata-rata (mean) atas jawaban yang telah diberikan oleh responden. Hasil analisis menunjukkan tingkat keberhasilan implementasi SIMRS adalah tinggi dengan skor rata-rata kualitas sistem, kualitas informasi, kualitas layanan, penggunaan sistem, kepuasan pengguna, struktur, lingkungan, dan manfaat berturut-turut adalah 3,0; 2,9; 2,9; 3,2; 2,7; 3,1; 3,2; dan 3,0. Masih diperlukan pengembangan baik pada aspek teknologi, manusia, dan organisasi guna meningkatkan kualitas layanan pasien di rawat inap RS Santo Borromeus.Kata kunci:  SIMRS; evaluasi sistem informasi; imlementasi SIMRS
Metode Hanlon Sebagai Cara Menentukan Prioritas Masalah Perencanaan dan Pengadaan Obat di RS Wijayakusuma Purwokerto
Authors: Lubis Muammar , Yuniarti Endang , Wiedyaningsih Chairun
Published: October 2024

Metode Hanlon adalah sebuah metode yang digunakan untuk membandingkan berbagai macam masalah kesehatan secara adil dan obyektif, serta sebagai dasar untuk merencanakan strategi perbaikan guna meningkatkan pelayanan. Tujuan penelitian ini untuk mengetahui gambaran pengelolaan obat tahap perencanaan dan pengadaan di RS Wijayakusuma Purwokerto dibandingkan dengan indikator standar dan dilakukan penetapan prioritas masalah dengan metode Hanlon kemudian memberikan rekomendasi perbaikan untuk penyelesaian masalah. Rancangan penelitian bersifat deskriptif, pengambilan data secara retrospektif dan concurent. Data yang dihasilkan berupa data kuantitatif dari penelusuran dokumen tahun 2022 dan penilaian metode Hanlon pada saat penelitian. Indikator standar yaitu kemenkes RI (2010), Satibi et al. (2019) dan Pudjaningsih (1996). Pemilihan responden penilaian metode Hanlon secara purposive sampling. Hasil penelitian menunjukkan, tiga indikator tidak memenuhi standar yaitu persentase kesesuaian jumlah permintaan (83,21%) dengan nilai OPR (22,65), persentase dana yang tersedia terhadap dana yang dibutuhkan (75,38%) dengan nilai OPR (26,15) dan frekuensi tertundanya pembayaran oleh RS terhadap waktu yang telah ditetapkan (32 kali) dengan nilai OPR (23,52). Kesimpulan dari penelitian ini bahwa prioritas utama diselesaikan yaitu indikator kecukupan dana, kedua indikator tertundanya pembayaran faktur dan ketiga indikator kesesuaian jumlah permintaan. Rekomendasi perbaikan: melakukan evaluasi dan penyesuaian anggaran, penyediaan anggaran yang memadai, menerapkan sistem pengadaan yang kompetitif dan meningkatkan fleksibilitas pengadaan obat.
Current Self-Medication Practices and Literacy among People in Yogyakarta Province, Indonesia: A Cross-Sectional Study
Authors: Ekasari Marlita Putri , Kristina Susi Ari , Yuliani Rizka Prita
Published: October 2024

In developing countries, self-medication is now becoming a common lifestyle as primary health care. Despite the benefits, the current challenges of inappropriate self-medication practices have potential risks for drug abuse and can lead to drug resistance. Therefore, the aim of this descriptive cross-sectional study was to assess the practice of self-medication related to public knowledge and health literacy in Yogyakarta Province among a sample of 954 respondents who consented to fulfill a validated questionnaire. A convenience sampling approach was applied. Descriptive analysis was performed to describe knowledge and practice of self-medication, and a chi-square test was used for bivariate analysis (p<0.05). The majority of respondents are female (62.58%) with age more than 50 years old (32.91%), and have chronic diseases (38.26%). Moreover, 43.29% of respondents have a low educational background. The results showed predominantly of the respondents had poor knowledge (51.39%) and lack of medicine literacy (53.88%). It seems educational background and chronic medical conditions are associated with the poor practice of self-medication. In conclusion, respondents in Yogyakarta had low knowledge and health literacy level of self-medication and it performs a poor practice. Health education of self-medication should be considered to improve the appropriate practices, especially among individuals with chronic diseases.
Herding Behavior and Its Impact on Purchasing Decisions Among Beginner Crypto Investors: An Experimental Analysis
Authors: Wijaya Yohanes Hendy , Elgeka Honey Wahyuni Sugiharto
Published: October 2024

In recent years, cryptocurrency has garnered significant interest from investors. Herding behavior bias frequently influences the rationality of purchasing decisions in novice crypto investors. In addition, greed can affect the decision-making process regarding the nominal of investment. This study aimed to examine the role of herding behavior in novice crypto investors' purchasing decisions and assess the role of greed as a moderator. The study employed an experimental method with a posttest-only control group design. Thirty participants were selected using convenience sampling techniques and divided into two groups (experiment and control groups). Data analysis was conducted using the Mann-Whitney U test for comparison testing and PROCESS Hayes for moderation analysis. The results indicated that herding behavior played a significant role in purchasing decision-making (U = 60; p < 0.05), whereas greed did not serve as a moderator in the relationship between herding behavior and nominal decision-making (b = -0.001; CI = -0.075, 0.072; p > 0.05). Instead of relying on rational decision-making, novice cryptocurrency investors frequently succumb to herding behavior. The ambiguity of information and investors' inability to make informed decisions lead to herding behavior being perceived as the most viable option.
Can Religious Modest Dress be Included in the Feminist Project
Authors: Barry Lucy
Published: October 2024

In 2009, Nicolas Sarkozy, the former French president, claimed that the burqa was not a symbol of faith but rather a sign of enslavement, and was therefore unwelcome in French society (La Fornara, 2018). Feminism aims to free women from any such ‘enslavement’ that would act as a barrier to gender equality. Nevertheless, the intersectional injustices that impact religious women make this debate more complicated than what Sarkozy suggested. This essay will therefore explore the ethical significance of religious modest dress, and advocate for its compatibility with the feminist project. This will be achieved through focusing on Jewish and Muslim women, living as minoritised groups in Western countries. While religious patriarchal structures seem to contradict the strive for gender equality through dictating how women present themselves, this should not permit the Western world to act as ‘saviours’ and reduce these women to victims. Instead, they should be included in the feminist cause and an effort should be made to truly understand their perspectives in order to strive for a modern world that treats men and women from all backgrounds more equally than it does currently.
Long-Term Impact of Mergers and Acquisitions on Firm Performance: A Panel Data Study
Authors: Anchan Veerendra
Published: October 2024

Purpose - This study aims to examine the long-term impact of mergers and acquisitions (M&As) on firm performance, particularly within the pharmaceutical industry. Using a panel data regression model, the study assesses how key financial ratios such as Net Profit Margin, Return on Capital Employed (ROCE), Debt to Equity Ratio, and Enterprise Value influence postmerger firm performance over time. Design/methodology/approach - A panel data approach has been conducted using data from 10 pharmaceutical companies from their post-merger period, focusing on the effects of M&As on firm performance as measured by Net Profit Margin. Financial ratios related to profitability, liquidity, and valuation were used as independent variables. Findings - The study finds that M&As have a positive long-term impact on firm performance, particularly in companies with strong Earnings per Share (EPS), efficient capital management, and good liquidity. ROCE, Debt to Equity Ratio, and Current Ratio were significant predictors of improved Net Profit Margin, highlighting the importance of financial efficiency and debt management in the post-merger phase. Research limitations/implications - The focus on the pharmaceutical industry limits the generalizability of the findings to other sectors. Future studies should examine a broader range of industries to better understand the effects of M&As across different contexts
A Review of Environmental Conditions between Planned and Unplanned Urbanization with Special Emphasis on Kalyani and Ranaghat Urban Areas
Authors: Paul Suvajit
Published: October 2024

Urban settlements in India are generally classified as planned or unplanned as opposed to planned or unplanned urban areas due to land use and taking into account various factors including physical social and economic considerations and land use patterns. Rapid urban growth in India, mostly in an unplanned fashion, is currently a major problem. Urban growth occurs through replacement of vegetation, agricultural areas, wetlands, etc. This results in an unprecedented increase in heat, which dominates the microclimate of urban areas and creates an environmental crisis. Geospatial technology plays a unique role in planned and unplanned urban areas of West Bengal by monitoring spatio-temporal changes in urban heat by estimating land surface temperature and analyzing built-in indices of vegetation cover. It can be classified as NDVI and NDBI suggests that urban heat is controlled by surface character which is analyzed for proper planning for sustainability of urban areas
ASPECTOS DE ESTRESSE DO CUIDADO AOS IDOSOS E ESTRATÉGIAS DE COPING NO CONTEXTO DA ATENÇÃO DOMICILIAR
Authors: Sena Juliana Pinto de , Rocha Tatiana Silva da , Silva Alandelon Dourado da , Nascimento Isabel Regiane Cardoso do
Published: October 2024

The global demographic transition projects an increase in the elderly population by 2050, impacting Brazil. Scientific advances contribute to an epidemiological transition, with an increasing prevalence of chronic non-communicable diseases (NCDs), such as diabetes and hypertension. The Home Care Service (SAD), known as the “Better at Home Program”, emerges as an alternative for patients with reduced mobility, with family caregivers playing a crucial role. This research aimed to investigate the challenges faced by caregivers and their coping strategies, based on the Folkman and Lazarus Coping Model. Conducted in Fortaleza-CE, a research used qualitative methods, including sociodemographic questionnaires, semi-structured interviews and the Scale to assess the burden of caregivers of elderly people. The results highlight the burden of caregivers and identify two main coping strategies: problem-focused and emotion-focused, showing how these strategies are adaptive mechanisms in the face of burden. These findings reinforce the importance of supporting caregivers in the context of SAD, emphasizing the need for interventions that promote coping strategies to deal with the challenges associated with home care for patients with NCDs.
Selecting an analytical model and quantitative indicators for geoinformation analysis of territorial entities sustainable development
Authors: Zhurkin I.G. , Orlov P.Yu. , Gruzinov V.S. , Mineev A.N.
Published: October 2024

Currently, there are no generally accepted algorithms for assessing, analyzing and forecasting the sustainable development of administrative-territorial units. The authors introduce the definition of this term, which implies the successful functioning of a human community over time carrying out economic activities without threats to its environment. Also, an analytical model for representation of its regional integrated indicator in the form of a vector with differential components, which characterize economic growth, environmental and social metrics, in a three-dimensional affine space, is proposed. Furthermore, we present a multiplicative criterion for assessing partial criteria of sustainable development efficiency and the basic expression for its parameters computation based on the set of economic, environmental and social ones, including such as the availability and quality of natural resources, regional labour resources, eco-factors, etc. The proposed vector model is based on the geoinformation approach and can be deployed within the framework of GIS of sustainable development for geo-analysis, modeling and mapping of natural resource potential and ecological state of intensively advancing territories, considering the dynamics of this process. Important properties of the geoinformation approach to assessing territorial entities’ forward growth, spatial and semantic scalability, are noted. In addition, the functional requirements and preliminary architecture of the core, modules, clients and layers of the related thematic geographic information system for the management, planning and forecasting the said indicator within the framework of digital economy are described
Technology adoption at scale: the success of USAID’s agriculture diversification project in Malawi
Authors: Said Jonathan , Goldsmith Peter
Published: October 2024

Dr. Fenton Sands, USAID’s new contract representative, faced some challenges. His office, USAID-Malawi over many years showed great commitment to the country, yet there seemed to be insufficient progress in poverty reduction, agricultural yield improvement, and smallholder farmer incomes. Now in 2017, the mission managed 25 different multimillion-dollar projects that touched on agriculture, the economy, resilience, gender, and nutrition, with little sustainability evident. Dr. Sands’ task was twofold, specifically, how to depart from past practice and actually achieve sustainable impact at scale here in Malawi, as he launched the new $60m Ag Div activity and more generally, if successful, how should USAID scale the success across the region. This case study provides unique insights into how Dr. Sands and his team jettisoned traditional development approaches and builds sustainable economic impact at scale through a novel private sector platform. USAID Malawi’s brave new venture successfully leveraged university research via the Soybean Innovation Lab to assure sound science and evidenced based decision making. Dr. Sand’s novel approach, presented here as a teaching case study, provides an explicit pathway for development officers, university researchers, program implementers, and leaders in the donor community to build sustainable impact in partnership with the private sector.
Hacia una plataforma de apoyo al multilingüismo de señas
Authors: Chacón-Rivas Mario , Schlunzen Junior Klaus
Published: October 2024

El uso y aprendizaje de las lenguas de señas es de interés tanto de personas sordas como oyentes, ya que esto garantiza los derechos de acceso a la información para todo tipo de personas.   Por lo que el crear tecnologías de apoyo para el uso, mejora y dominio de las lenguas de señas es de vital importancia, y más aun si estas tecnologías apoyan el multilingüismo en un mundo tan globalizado.  Por esta razón el proyecto PIELS como plataforma internacional de edición de lengua de señas, busca la unión del Instituto Tecnológico de Costa Rica y de universidades del estado de Sao Paulo, para enriquecer una plataforma con contenidos en LESCO y LIBRAS que apoyen el multilingüismo.
Towards a legal framework for corporate governance amid artificial intelligence.
Authors: Al-Mahameed Mohammad
Published: October 2024

This paper addresses the procedures to develop a legal framework for corporate governance amid artificial intelligence technology in Jordanian legislation. The analytical and descriptive approach is adopted to analyze the texts of the Jordanian Companies Law No. 22 of 1997, its amendments, and Instructions for the Corporate Governance for Shareholding Listed Companies for the year 2017. Though the Jordanian legislation has established rules and principles of governance, whether, in the corporate law or governance instructions, the Jordanian legislation does not incorporate legal texts that simulate the artificial intelligence into these principles (Yazid, 2016). The results demonstrate that the Jordanian legislation is still in the process of organizing and legalizing the concept of artificial intelligence in the Jordanian Companies Law and the principles of commercial companies’ governance. With that, this article recommends that the Jordanian legislator should amend the law that regulates artificial intelligence issues in the governance of commercial companies to keep up with the development in the era of the digital economy. This would protect commercial companies and those with interests in them by enhancing the principles of transparency, independence, and disclosure, and preserving information security in them according to the artificial intelligence.
Optimizing the potential of meeting, incentive, conference, and exhibition destinations through a creative economic development model: A local government study
Authors: Rumerung Jeaneta , Mundung Deky , Manopo Meiske , Rumimper Grace
Published: October 2024

Manado City is a potential meeting, incentive, conference, and exhibition (MICE) destination because it has a strategic position as a gateway for international trade in Eastern Indonesia. The MICE industry is a driving force for the creative industry through MICE activities (Fitri, 2020). The suboptimal development of the creative economy has an impact on the underdevelopment of the MICE industry. The main objective of this research is to design a creative economy development model that has an impact on optimizing the potential of MICE destinations. The research design uses qualitative research. Data analysis in this research uses strengths, weaknesses, opportunities, and threats (SWOT) analysis and the quadruple helix model. The research results show that the development of the creative economy using the quadruple helix development model which describes the role of four helixes has a positive impact on optimizing the potential of MICE destinations.
A Two-Dimensional Amplitude Study of True-Amplitude Time Migration and Time Remigration – 2.5-D Synthetic Examples
Authors: Augusto Sarmento Ferreira Carlos , P. Gomes Karina , S. Oliveira Alexandre
Published: October 2024

In this synthetic study, we present semi-automatically picked true-amplitude comparisons after time migration and time remigration (Tygel et al.,1996; and Oliveira et al.,2023). Since the examples considered are synthetic, emphasis is put on the generally disregarded dimensional aspects of the amplitudes that are modeled to simulate compressional-only seismic data when using a Kirchhoff a p proximation. By bearing in mind in this work that theoretical amplitudes work as “densities”, we show that when comparisons of true-amplitude weighted diffraction-stack time migration and weighted isochrone-stack time remigration are performed, in order to “correct” the dimensions involved certain multiplicative physical constants must come into play and that must be effectively dealt with, for plotting reasons.
Econometric analysis of factors influencing export performance of soybean (Glycine max) production in NIGERIA: An auto-regressive distributive lag (ARDL) approach
Authors:   Kaduna State University (KASU), Kaduna State, Nigeria, Maharazu Ibrahim , Alabi Olugbenga Omotayo ,   University of Abuja, Federal Capital Territory, Nigeria, Atteh Paul Akinwumi ,   Federal University of Lafia, Lafia, Nasarawa State, Nigeria, Obida Augustine ,   Federal University of Agriculture, Zuru, Kebbi State, Nigeria
Published: October 2024

This study presents an econometric analysis of factors influencing the export performance of soybean (Glycine max) production in Nigeria using an auto-regressive distributive lag (ARDL) approach. The study used a secondary data covering the period from 2011 to 2022. The used data were collected from CBN (Central Bank of Nigeria), NBS (National Bureau of Statistics), FAO (Food and Agriculture Organization), and the General Household Survey-Panel (GHS-P) in conjunction with the Federal Ministry of Agriculture and Rural Development, and the World Bank publication. The data analysis included descriptive statistics, Augmented Dickey-Fuller (ADF) unit root test, Bound test, ARDL, and principal component model. The result of the ADF unit root test showed that the trade openness, consumer price index, exchange rate, population growth, world trade in oil seeds, agricultural labor, and soybean production were stationary at first difference I (1), while agricultural machinery was stationary at level I (0). The results of ARDL method showed that the consumer price index, population growth rate, world trade in oil seeds, agricultural labor, and agricultural machinery were significant factors influencing export performance of soybean in Nigeria. The trade openness and exchange rate were not different significantly from zero. The trade openness could not expand market access due to non-competitiveness of the Nigerian’s soybean. The exchange rate has lost its role with respect to soybean seed partners in international trade. The policies that would encourage exportation of this crop should be pursued by provision of storage facilities, granting of tax holidays, long term export credit at concessionary interest rate to exporters, and research activities towards improving the quality of produced agricultural products. Keywords: Export Performance, Augmented Dickey-Fuller, Auto-Regressive Distributive Lag, Soybean Production, Nigeria
Determinants of profit among maize farmers in Osogbo ADP zone of Osun State, Nigeria
Authors:   Osun State University, Osogbo, Nigeria, Akintunde Olaide K. , Jimoh Lateef O. ,   Osun State University, Osogbo, Nigeria, Idris-Adeniyi Kaothar M. ,   Osun State University, Osogbo, Nigeria, Bamiwuye Olubunmi A. ,   Osun State University, Osogbo, Nigeria
Published: October 2024

Maize output in Nigeria is declining and worsening economic situations continue to afflict rural households increasing the level of food insecurity. This study examined the determinants of profit among maize farmers in Osogbo ADP zone of Osun State, Nigeria. Primary data were sourced using a well-structured questionnaire from a total of 120 maize farmers. A two-stage sampling procedure was employed to select the farmers. The analytical tools used were descriptive statistics, farm budgetary techniques and regression analysis. The results showed that maize cultivation was dominated by male farmers with an average age of 50 ± 9.4 years. Additionally, less than 30.8% of the maize farmers had formal education above secondary school. The farming experience of the maize farmers was 14.7 ± 5.3 years and the average farm size was estimated at 7.85 ± 2.15 acres. The average farm income was N207 314.40 ± 23 290.95 with the Benefit-Cost Ratio (BCR) of 2.24. The major constraints of maize production, ranked based on their higher values of WMS, were the high labour costs, expenditures for pest and disease control, and the high costs of fertilizers The determinants of farm income that had positive relationship and were significant at 1% level of significance include years of formal education, expenditure on fertilizer while age of the framers negatively influenced the farm income. Also, the farm size and years of farming experience were positive and statistically significant to farm income at 5%. The study suggests a policy focus of training farmers in modern farming system and implement sustainable farm inputs subsidy programs. Keywords: determinants, profit, maize, farmers, Nigeria
An age-group ranking model for facial age estimation
Authors: Akinyemi Joseph D. , Onifade Olufade F. W.
Published: October 2024

Age prediction has become an important Computer Vision task. Although this task requires the age of an individual to be predicted from a given face, research has shown that it is more intuitive and easier for humans to decide which of two individuals is older than to decide how old an individual is. This work follows this intuition to aid the age prediction of a face by exploiting the age information available from other faces. It goes further to explore the statistical relationships between facial features within age groups to compute age-group ranks for a given face. The resulting age-group rank is low-dimensional and age-discriminatory, thus improving age prediction accuracy when fed into an age predictor. Experiments on publicly available facial ageing datasets (FGnet, PAL, and Adience) reveal the effectiveness of the proposed age-group ranking model when used with traditional Machine learning algorithms as well as Deep Learning algorithms. Cross-dataset validation, a method of training and testing on entirely different datasets, was also employed to further investigate the effectiveness of this method.
Internal Connectedness and Accrual Quality: Evidence from Employee LinkedIn Connections
Authors: Li Shelley Xin , Zhou Aner
Published: October 2024

SYNOPSIS

We investigate the impact of employee connectedness on a firm’s accrual quality. Using data from the largest professional network, LinkedIn, we measure the degree to which employees are connected—which we label “internal connectedness”—and are therefore likely to interact and share information. We hypothesize and find that a firm’s internal connectedness increases its accrual quality and that the positive effect is stronger when external monitoring or internal formal monitoring is weaker or when accrual estimation is more difficult. That is, the effects of internal connectedness are stronger when greater benefits can be expected from enhanced informal internal information sharing. Our results provide insights for academics and practitioners in understanding the determinants of financial reporting quality and the crucial yet often neglected role of the internal information environment.

Data Availability: Data are available from the sources cited in the text.
5. Offloading the Diabetic Foot Wound
Authors: Wu Stephanie C. , Armstrong David G. , Crews Ryan T.
Published: October 2024

Nonremovable Knee-High Offloading Devices Removable Offloading Devices Other Offloading Techniques Surgical Offloading Contralateral Footwear Considerations Conclusions References
6. Debridement of the Diabetic Foot
Authors: Meyr Andrew J. , Steinberg John S. , Kim Paul , Attinger Christopher E.
Published: October 2024

Timing of a Debridement Surgical Debridement Nonsurgical Modes of Debridement After Debridement Summary References
8. Dressings and Local Wound Care for People with Diabetic Foot Wounds
Authors: Badran Fatimah , Chyung Kevin , Sibbald Gary
Published: October 2024

Treating the Cause of Diabetic Foot Wounds Patient-Centered Concerns Determine Healability Local Wound Care Case Vignette 1 Case Vignette 2 Case Vignette 3 Evidence-Informed Dressing Selection Summary Acknowledgement References Suggested Readings
12. Evaluation and Management of Peripheral Artery Disease
Authors: Mills Joseph L.
Published: October 2024

Arteriosclerosis Obliterans Myths about PAD Treating Infection Pulse Palpation and Noninvasive Vascular Testing Surgical and Endovascular Revascularization Options Summary References Suggested Readings
13. Interdisciplinary Team Approach to Targeted Diabetic Foot Care
Authors: Armstrong David G. , Khan Tanzim , Mills Joseph L.
Published: October 2024

Team Approach and a Viable Model The Interdisciplinary Pathway Toe and Flow References
Vivencias de líderes sociales afro e indígenas ante amenazas en Cauca, Colombia, en 2020
Authors: Chía Cepeda Luz Carime
Published: October 2024

Este artículo examina las vivencias emocionales de los líderes sociales y comunitarios del consejo afrodescendiente Zanjón de Garrapatero y el resguardo indígena de Canoas, frente a las amenazas en 2020, en Santander de Quilichao, Cauca, Colombia. Estos líderes trabajan para transformar y proteger los territorios; fortalecer la cultura, la educación y la inclusión étnica en los sistemas, y defender los derechos humanos. No obstante, debido a sus acciones, se ha venido evidenciando un incremento en las amenazas hacia su integridad personal, lo que genera vivencias emocionales sobre las que no hay registro. Se evidencia, por lo tanto, una situación que merece ser analizada y visibilizada para desarrollar alternativas de actuación diferenciada frente a los hallazgos.
Calidad de la gestión con base en resiliencia organizacional. Experiencia SENA-Tolima, 2005-2016, Parte 1
Authors: Trujillo Hoyos Manuel César , Castro Bocanegra Fabian Enrique
Published: October 2024

Este artículo evidencia la experiencia de implementar, en el periodo 2005-2016, el estilo de dirección denominado Calidad de la gestión, en el SENA-Regional Tolima, en el contexto de la teoría de la resiliencia, la calidad de la gestión y la calidad organizacional, todo esto asociado con los atributos de la cultura escrita y el control integral en la gestión, asumidos como buenas prácticas de gestión institucional (BPGI). Se eligió el método descriptivo para mostrar el proceso de la implementación que pretendía motivar el desarrollo del compromiso institucional con el sistema de gestión de la calidad, su certificación y mejora