bluuebunny/crossref_metadata_2025 huggingface dataset:
MetodologÃ­a basada en procesos para la implementaciÃ³n de un sistema de gestiÃ³n de la investigaciÃ³n formativa en la universidad peruana.
Authors: Mendoza de los Santos Alberto
Published: November 2019

La presente investigaciÃ³n presenta una proposiciÃ³n metodolÃ³gica para facilitar la implementaciÃ³n de un sistema que gestione la investigaciÃ³n formativa en la universidad peruana, que permita a su vez fortalecer el sistema investigativonacional y garantice el cumplimiento de la Ley Universitaria NÂº 30220Con esta metodologÃ­a se espera contribuir al impulso de fortalecer la investigaciÃ³n formativa en las universidades peruanas, tan necesaria para dar ese gran salto que se requiere para hacer de nuestro paÃ­s, un paÃ­s que investiga y genera conocimiento propio.

Palabras clave: Sistema de gestiÃ³n, InvestigaciÃ³n.
Rubber band ligation of hemorrhoids: a hospital based study
Authors: Mir Irfan Nazir , Rashid Tajamul , Suhail Malik , Kumar Irshad Ahmad
Published: November 2019

Background: Hemorrhoids are symptomatic anal cushions containing arteriovenous anastomosis. Patient with haemorrhoids can present as bleeding per rectum, something (mass) coming out per rectum, perianal itching, Anaemia due to occult blood loss. Various modalities of treatment have been developed to treat symptomatic haemorrhoids. This study was undertaken to determine the efficacy of rubber band ligation in the management of haemorrhoids.Methods: This study was a prospective study conducted in the Department of Surgery, Government Medical College, Srinagar from June 2015 to June 2018. Patients at any age with first, second- or third-degree internal haemorrhoids were included in the study. Patients with fourth degree, complicated haemorrhoids, previous anorectal surgery or anorectal pathology, and chronic liver disease were excluded. A total of 212 patients were included in the study. Rubber band ligation was done as an OPD procedure. The patients were followed at 2 weeks, 4 weeks, 3-month, 6 month and 1 year after the procedure.Results: In this study, out of 212 patients, 154(72.6%) were males and 58(27.4%) females. The mean age of this study was 38.7 yr. (Range 17-73 yr.). Patients presented with the complaints of bleeding (184, 86.8%), prolapse (114, 53.7%), constipation (116, 54.7%), priuritis ani (36, 17.0%), pain (12, 5.6%). Band ligation was successful in 188(88.8%) patients, 169(79.7%) patients were cured and in 19(8.9%) improvement was obtained. Various complications occurred after band ligation including vasovagal syncope (2, 0.9%), bleeding per anum (6, 2.8%), pain (12, 5.6%), fissure in ano (1, 0.5%). Recurrence after one year was seen in 9(4.2%) patients.Conclusions: Author concluded in this study that RBL is an effective outpatient treatment for grade II and III internal haemorrhoids without much complications.
Specific inhibition of procollagen C-endopeptidase activity by synthetic peptide with conservative sequence found in chordin.
Authors: Lesiak Marta , Augusciak-Duma Aleksandra , Szydlo Anna , Pruszczynska Ksymena , Sieron Aleksander L
Published: November 2019

Procollagen C-endopeptidase (BMP-1) and N-endopeptidase (ADAMTS-2) are key enzymes for correct and efficient conversion of fibrillar procollagens to their self assembling monomers. Thus, they have an essential role in building and controlling the quality of extracellular matrices (ECMs). Here, we tested inhibition of activity of the largest variant of BMP-1, a recombinant mammalian tolloid (mTld), in vitro by three synthetic peptides with conservative amino-acid sequences found in chordin using procollagen type I as a substrate. We also verified the specific action of best inhibitory 16 amino-acid peptide in the procollagen type I cleavage assay with the use of ADAMTS-2 (procollagen N-endopeptidase). Subsequently, we determined the critical residues and minimal sequence of six amino acids in the original 16 amino-acid peptide required to maintain the inhibitory potential. Studies on the interactions of 6 and 16 amino acid long peptides with the enzyme revealed their binding to non-catalytic, regulatory domains of mTld; the inhibitory activity was not due to the competition of peptides with the substrate for the enzyme active center, because mTld did not cleave the peptides. However, in the presence of mTld both peptides underwent cyclization by disulfide bond formation. Concluding, we have shown that procollagen C-endopeptidase may be specifically blocked via its non-catalytic domains by synthetic peptide consisting of 6 amino acids in the sequence found in highly conservative region of chordin. Thus, we hypothesize that the 6 amino-acid peptide could be a good candidate for anti-fibrotic drug development.
Corpora amylacea from multiple sclerosis brain tissue consists of aggregated neuronal cells.
Authors: Selmaj Krzysztof , Pawłowska Zofia , Walczak Agata , Koziołkiewicz Wiktor , Raine Cedric S , Cierniewski Czesław S
Published: November 2019

In this report, we describe proteomic analysis of corpora amylacea collected by postmortem laser microdissection from multiple sclerosis (MS) brain lesions. Using low level protein loads (about 30 microg), a combination of two-dimensional electrophoresis with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and database interrogations we identified 24 proteins of suspected neuronal origin. In addition to major cytoskeletal proteins like actin, tubulin, and vimentin, we identified a variety of proteins implicated specifically in cellular motility and plasticity (F-actin capping protein), regulation of apoptosis and senescence (tumor rejection antigen-1, heat shock proteins, valosin-containing protein, and ubiquitin-activating enzyme E1), and enzymatic pathways (glyceraldehyde-3-dehydrogenase, protein disulfide isomerase, protein disulfide isomerase related protein 5, lactate dehydrogenase). Samples taken from regions in the vicinity of corpora amylacea showed only traces of cellular proteins suggesting that these bodies may represent remnants of neuronal aggregates with highly polymerized cytoskeletal material. Our data provide evidence supporting the concept that biogenesis of corpora amylacea involves degeneration and aggregation of cells of neuronal origin.
Ergenlerde Olumlu ve Olumsuz Duygulanımın Yordanmasında Temel Psikolojik İhtiyaçlar İrrasyonel İnanışlarının Rolü
Authors: ARTIRAN Murat
Published: November 2019

Öz Belirleme
Kuramı, motivasyonu belirleyici olan değişkenlerin insanların yeterlilik,
özerklik ve aidiyet temel psikolojik ihtiyaçları olduğunu iddia eder. Bu
araştırmada irrasyonel ve işlevsiz düşünsel süreçler üç temel psikolojik
ihtiyaç bağlamında pozitif ve negatif duygular ile birlikte sınanmıştır. Veri
seti 207 katılımcının katılımıyla oluşturulmuştur. Bulgular temel psikolojik
ihtiyaçlar irrasyonel inanışlarının negatif duygular ile orta derecede, pozitif
duygular ile zayıf derecede ilişkili olduğunu ortaya koymuştur. Sonuçlar özerklik,
yetkinlik ve aidiyet irrasyonel inanışlarının negatif duyguları, özerklik ve
aidiyet psikolojik ihtiyaçları irrasyonel inanışlarının da pozitif duyguları yordadığını
göstermektedir. Yetkinlik irrasyonel inanışlarının ise pozitif duyguları yordamadığı
bulgulanmıştır. Sonuçlar temel psikolojik ihtiyaçların irrasyonel inanışlarının
psikoloji alanında diğer değişkenlerle
araştırılmasının gerekliliğini ortaya koymuştur.
Ortaokul Öğrencilerinin “Güneş Sistemi” İle İlgili Zihinsel Modelleri
Authors: GÖRECEK BAYBARS Meryem , ÇİL Mustafa
Published: November 2019

Bu araştırmanın amacı
ortaokul öğrencilerinin “Güneş sistemi” ile ilgili zihinsel modellerinin
belirlenmesidir. Araştırma, 2017-2018 eğitim-öğretim yılı bahar döneminde
Türkiye’nin batı bölgesinde yer alan iki devlet okulunun tüm ortaokul
öğrencileri ile gerçekleştirilmiş olup, araştırmaya toplam 340 öğrenci
katılmıştır. Araştırmada kullanılan veri toplama aracı, iki açık uçlu sorudan
oluşmaktadır. Veri toplama aracında yer alan sorular, öğrencilerin Güneş
sistemini betimleme ve görselleme durumlarını ortaya çıkaracak şekilde
hazırlanmıştır. Veri analizinde, öncelikle öğrencilerin Güneş sistemini
betimleme ve görselleme durumları ayrı ayrı analiz edilmiş, sonra betimleme ve
görselleme sorularına verilen cevaplar birlikte değerlendirilerek öğrencilerin
zihinsel modelleri belirlenmiştir. Araştırma sonucunda ortaokul öğrencilerinin
“Güneş sistemi” ile ilgili bilimsel zihinsel modele sahip olmadığı,
öğrencilerin daha çok sentez ve ilkel model düzeyinde zihinsel modele sahip
olduğu sonucuna ulaşılmıştır.
DESEMPENHO ECONÔMICO DAS EMPRESAS FAMILIARES E NÃO FAMILIARES NA CRISE DE 2012
Authors: Lunardi Micheli Aparecida , Hein Nelson , Kroenke Adriana
Published: November 2019

Esta pesquisa consistiu em analisar o comportamento do desempenho econômico das empresas familiares e não familiares na crise de 2012 das empresas brasileira listadas na BM&FBovespa. Para tanto, desenvolveu-se um estudo descritivo, documental e quantitativo, com a utilização da distância DP2. O período de análise compreendeu os anos de 2008 a 2016. Os resultados revelaram que nos anos de 2008 a 2012 as empresas familiares obtiveram valores de desempenho econômico superior às empresas não familiares, apresentando melhor posicionamento da distância DP2. Nos quatro anos avaliados posteriores a crise de 2012, as empresa que apresentaram melhor posicionamento no ranking forma as empresas não familiares. Nos anos de 2011, 2012 e 1013 as empresas familiares apresentaram melhor colocação no ranking. Conclui-se que houve uma mudança no comportamento econômico das empresas familiares e não familiares principalmente nos anos próximo a Crise de 2012, sendo que as empresas familiares passaram a ocupar o primeiro lugar no ranking de desempenho econômico, quando anteriormente era mantido pelas empresas não familiares. Sendo assim, em um cenário de crise o desempenho econômico das empresas familiares são superiores as empresas não familiares. Como contribuição, o estudo apresenta o comportamento econômico das empresas familiares e não familiares, indicando como o desempenho econômico das empresas familiares e não familiares se comportam em um cenário de crise.
Imagen del destino desde la perspectiva del turista
Authors: Castro Analuiza Juan Carlos , Palacios Pérez Jheimy Morelia , Plazarte Alomoto Lauro Vladimiro
Published: November 2019

La imagen del destino turístico influye en la calidad percibida, la satisfacción y la experiencia de las vacaciones de los visitantes. El objetivo del estudio fue analizar la formación de dicha imagen mediante la revisión sistemática de informes de investigación que consideran la combinación de los tres continuos bipolares. Se llevó a cabo el meta análisis sobre la base de estudios previos en distintos campos, como ocio, hotelería, turismo y marketing. El proceso meta analítico de 46 artículos se desarrolló a partir del análisis de efectos aleatorios. Se destaca que el continuo con mayor representatividad en la imagen del destino es el común-único. Se demuestra que el turista toma su decisión de visita con base en características comunes funcionales, psicológicas y aquellas características únicas y exclusivas que proporciona un destino. Por lo tanto, los resultados del estudio aportan significativamente a la gestión del marketing de destino.
La banalización de la aventura: la (POS) modernización de la actividad turística
Authors: Botero-Cedeño Eduardo Andrés
Published: November 2019

El presente es un excurso crítico que se deriva de las reflexiones preliminares del ejercicio de tesis doctoral tentativamente titulado “De la energéia a la dynamis: bases conceptuales para una aprehensión crítica y compleja de la organización antroposocial”. En este caso concreto, se trata de un análisis de los procesos de producción y consumo de los servicios turísticos en la denominada era pos (posmoderna y posfordista) a partir de la mitocrítica como apuesta metodológica. Ha surgido en este ejercicio un argumento que se presenta como evidente y claro: la aventura heroica y el llamado trascendente implícitos en la actividad turística desde los albores de la humanidad han sido banalizados en medio de la vorágine consumista de la sociedad contemporánea. De igual manera, es claro que el planteamiento de la crítica en el marco de lo onírico/simbólico responde a una intencionalidad revolucionaria advertida por Žižek, para quien cualquier transformación radical de los dispositivos sociales, económicos, políticos y culturales deberá edificarse sobre estructuras imaginarias que permitan situar los problemas inherentes a la era pos en coordenadas analíticas distintas a las impuestas por la ideología consumista imperante.
Donald Trump’s Administration Confronting Missile Defence: Key Challenges and Probabilistic Overview
Authors: Nycz Grzegorz
Published: November 2019

The text describes main US missile defence efforts in the first years of D. Trump’s administration. The analysis of current aspects of BMD (Ballistic Missile Defence) deployments is enhanced by probability analysis examining missile defence reliability. Donald Trump took office in the time of increased military competition between the West and Russia and a dangerous regional crisis related to North Korean nuclear arsenal and its ballistic tests. BMD appeared to bring additional chances to US deterrence options in regional scale, allowing more successful first strike or active defence posture. Notably, D. Trump’s administration managed to raise defence expenditures including BMD spending.
Searching for Solid Ground in Polish-American Relations in the Second Year of the Trump Administration
Authors: Szklarski Bohdan , Ilowski Piotr
Published: November 2019

Since the beginning of the Trump Administration, analysts of American foreign policy have observed several changes in the style substance and style of Washington’s international behavior with regard to both foes and friends. President Trump in his rhetoric (including social media communication) and style represent a disturbing discontinuity, especially for allies that undermines the stability of American international commitments. American allies are forced to develop new strategies for managing this new risk in relations with Washington. This paper examines the tactics employed by the government in Warsaw in that regard.
A New Alliance against the US? Sino-Russian Relations in Response to Trump’s Redefined Foreign Policy Priorities
Authors: Ciborek Przemysław
Published: November 2019

The current state of bilateral relations between the Russian Federation and the People’s Republic of China is described by many international relations experts as the best in history. After taking the president office by Donald Trump, the bilateral relations between America and abovementioned powers are cooling down. Current foreign policy of the People’s Republic of China and the Russian Federation focuses on holding a common position in the international political arena, which is in fact an attempt to counterweight political influence of the US administration and their allies. The dimension of the strategic partnership between China and Russia is also determining the mutual economic dependence, which is now crucial for both powers to build a strong position on the international forum. In addition, Russia is one of the crucial partners for the Chinese-led Belt and Road Initiative (BRI) – by many recognized as the Chinese attempt to break the American economic domination. The collisional course of the American foreign policy towards Russia and China forces the latter to look for Central and Eastern European allies as well as to gain influence in the region of Central Asia which is leading to a constant increase in tensions between China and Russia.
Territorial Manifestations in Times of Globalization: Implications for State-Centrism in International Relations
Authors: Aleksandrova Boryana
Published: November 2019

Globalization challenges the state-centric realist view of space and authority within International Relations. Using multifaceted concepts of territoriality and non-territoriality, this article goes into three versions of current territorial fragmentation or connectivity – deterritorialization, extraterritorialization and reterritorialization. They are to enable us to reveal the proliferation of globally relevant social and power dynamics above, below and within the state domain. At the same time, they are to illuminate the ambivalent role of states played in an era of global interconnectedness.
Shia Armed Groups and the Future of Iraq
Authors: Rached Kardo , Bali Ahmed Omar
Published: November 2019

The rising and acceleration of the Shia armed group in Iraq, Syria, Yemen, and Lebanon require a deep understanding of the root of the multi-dimensional conflicts in the Middle East. An appropriate and sufficient approach to the research about these militias will be from an internal conflict rather than an external conflict. The legitimization for the existence of the majority of these militias if not all of them is to fight and struggle against an entity which is the Sunni sect, in this case, that will assimilate them not integrate them peacefully.
Prevalence of inflammatory bowel disease in the Chelyabinsk Region
Authors: Dolgushina A. I. , Khusainova G. M. , Vasilenko A. G. , Kononets V. A.
Published: November 2019

Background: Epidemiological data on the prevalence of ulcerative colitis (UC) and Crohn's disease (CD) in Russia are limited.

Aim: To evaluate the proportions and clinical particulars of inflammatory bowel diseases (IBD) in patients living in the Chelyabinsk Region.

Materials and methods: We performed a  retrospective analysis of a  database of IBD patients residing in the city of Chelyabinsk and the Chelyabinsk Region for the period from 2016 to 2019.

Results: The database includes 693 patients, among them 582 (84%) with UC and 111 (16%) with CD. With UC, the ratio of women (313 people) to men (269 people) was 1.16:1, while with CD (70 women and 41 men) it was 1.7:1. The mean age of UC patients was 46.3±15.8 years, of those with CD 45.79±18.1 years. 631 (90%) IBD patients live in the city, the number of rural residents was significantly lower (62, or 10%) (p<0.001). Disability caused by the underlying disease was 11.9% of the patients with UC and 23.4% of the CD patients. The mean age of the disease manifestation was 39.3±15.03 years (UC) and 38.7±17.8 years (CD). The time to diagnosis of UC was 6.1±4.0 months and of CD 7.6±5.5 months (р=0.045). Proctitis was diagnosed in 56 patients with UC (9.6%), left-sided colitis in 301 (51.7%), and total colitis in 225 (38.7%). Terminal ileitis was detected in 34 (30.6%) CD patients, colitis in 25 (22.6%), mixed colon and small intestine involvement in 52 (46.8%), and combined involvement of the upper gastrointestinal tract in 3 (3%) patients. The course of UC was acute in 25 (4.3%) patients, chronic continuous in 52 (8.9%), and chronic recurrent in 505 (86.8%). Extraintestinal manifestations were observed in 135 (19.5%) patients with IBD. Genetically engineered biological therapy was prescribed to 77 (11%) patients.

Conclusion: The epidemiological trends for IBD, which we have identified through the analysis of the database for the city of Chelyabinsk and the Chelyabinsk Region, are consistent with the results of studies in other regions of the Russian Federation: IBD manifests in the middle age, the time to diagnosis of CD is longer for that of UC. Total colitis is most frequent in UC, whereas in CD mixed colon and small intestine involvement is most prevalent. Ninety percent (90%) of IBD patients at the time of the database entry had a mild or moderate exacerbation of their disease.
Guenter Lewy Osmanlı Ermenilerine Ne Oldu ?
Authors: DURMAZ Gülseher
Published: November 2019

Guenter Lewy '1915 Osmanlı Ermenilerine Ne Oldu?' adlı kitabında Ermeni ve Türk ilişkilerini tarihsel çerçevede, iki tarih yazımı bağlamında analiz ederek aktarmayı hedeflemiştir.
The Role of Cultural and Artistic Institutions in Promoting the Values of Tolerance and Coexistence in the United Arab Emirates
Authors: Jarrah Hani Yousef , Serhan Hussein Salem
Published: November 2019

This study aims at revealing the role of cultural and artistic institutions in promoting the values of tolerance and coexistence in the United Arab Emirates (UAE). In this research, the researchers followed the analytical descriptive method and used the questionnaire for data collection. The study sample consisted of 80 randomly chosen employees of the cultural and artistic institutions in the UAE. Results show there are no statistically significant differences (α = 0.05) due to the effect of personal variables (gender, qualification, experience, type of work, nationality). The targeted institutions did not play their role appropriately in promoting the culture of dialogue and values of tolerance and promotion of human rights. It is recommended that there should be public relations programme aimed at developing a culture of tolerance and dialogue, allowing everyone to express their opinions and beliefs freely without hesitation or fear, and this is the case of those who are dealing with humanitarian affairs and democratic activities.
Witch-Hunting in Assam: Myth or Reality
Authors: Borah Lekha , Das Madhushree
Published: November 2019

Assam, like many other parts across the country, often witnesses deaths, injuries, and miseries resulting from witch hunting, an atrocious practice and a socially sanctioned violence. Reiterated incidents of killings in the name of witch-hunting have alarmingly challenged the laws and have led to various anti-witch hunting programs. Often veiled under superstition, the factors that render this social menace unabated is a matter of grave concern for every conscious mind. Official records suggest 196 cases of the terrible violence to occur in the state between 1989-2014, but newspaper reports and other agencies present the actual social reality which echoes manifold of official records. The practice of witch-hunting, however, is not evenly distributed in all the areas of Assam, but have gripping roots in the customary beliefs of many tribal communities residing in the state. This research, therefore, is an attempt to illuminate the genesis of the witch hunt in Assam from the perspective of a crime having cross-community dimensions. Further, gaining insights from primary field survey and secondary data, it is evident that accessibility plays a trump card in this case of witchcraft in Assam along with the superstitious belief of the communities, intermingling with personal motives, illness and devious role of ojhas (village medicine men) which exaggerates the menace.
Publication Watch
Authors: India Space and Culture,
Published: November 2019

Here are some of the latest open access articles from different journals of social sciences.  In addition,  there is information of  few  important information from open knowledge repository.
Entropy, Information and Symmetry: Ordered is Symmetrical
Authors: Edward Bormashenko
Published: November 2019

Entropy is usually understood as the quantitative measure of “chaos” or “disorder”. However, the notions of “chaos” and “disorder” are definitely obscure. This leads to numerous misinterpretations of entropy. We propose to see the disorder as an absence of symmetry and to identify “ordering” with symmetrizing of a physical system; in other words, introducing the elements of symmetry into initially disordered physical system. We demonstrate with the binary system of elementary magnets that introducing elements of symmetry necessarily diminishes its entropy. This is true for 1D and 2D systems of elementary magnets. Imposing symmetry does not influence the Landauer Principle valid for the addressed systems. Imposing the symmetry restrictions onto the system built of particles contained within the chamber divided by the permeable partition also diminishes its entropy.
Indigenous Pig Genetic Resources in Southern Africa: Progress and Prospects
Authors: Halimani Tinyiko Edward , Mapiye Obvious , Marandure Tawanda , Januarie Diedre , Chikosi Venancio Edward Imbayarwo , Dzama Kennedy
Published: November 2019

Pig genetic resources in Africa originate from different regions. Genetic analysis has shown a strong phylogeographic pattern with the pigs on the eastern parts showing a high frequency of alleles from the Far East while the ones on the western parts show a strong European influence. This highlights the influence of trade routes on the genetic legacy of African pigs. They have, however, since adapted to the local environments to produce unique populations with unique attributes. Most of the pigs are now reared in resource-constrained smallholdings under free-range conditions. They are largely owned by women who spread ownership of the resource through kinship networks. Very little work has been done to characterize, conserve and sustainably utilize pig genetic resources in Southern Africa. The risk status of the breeds together with population numbers, distribution and other attributes are largely unknown. This paper proposes several strategies for the sustainable utilization of the pig genetic resources: a market-driven in situ conservation program and two complementary ex situ strategies. In addition, the possibility of community-based breed improvement programs is discussed.
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren
Authors: Castañeda-Zegarra Sergio , Huse Camilla , Røsand Øystein , Sarno Antonio , Xing Mengtan , Gago-Fuentes Raquel , Zhang Qindong , Alirezaylavasani Amin , Werner Julia , Ji Ping , Liabakk Nina-Beate , Wang Wei , Bjørås Magnar , Oksenych Valentyn
Published: November 2019

Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological abnormalities and immunodeficiency both in humans and mice. The NHEJ pathway is required for the V(D)J recombination in developing B and T lymphocytes, and for class switch recombination in mature B cells. Ku heterodimer formed by Ku70 and Ku80 recognizes DSBs and facilitates the recruitment of accessory factors (e.g., DNA-PKcs, Artemis, Paxx and Mri/Cyren) and downstream core factors subunits XLF, XRCC4 and Lig4. Accessory factors might be dispensable for the process depending on the genetic background and DNA lesion type. To determine the physiological role of Mri in DNA repair and development, we introduced frame-shift mutation in the Mri gene in mice. We then analyzed the development of Mri-deficient mice as well as wild type and immunodeficient controls. Mice lacking Mri possessed reduced levels of class switch recombination in B lymphocytes and slow proliferation of neuronal progenitors when compared to wild type littermates. Human cell lines lacking Mri were as sensitive to DSBs as WT controls. Overall, we concluded that Mri/Cyren is largely dispensable for DNA repair and mouse development.
Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective
Authors: Kirlioglu Simge Seren , Balcioglu Yasin Hasan
Published: November 2019

Several lines of evidence support a relationship between circadian disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders. Current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. However, much more work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders, and to develop sound pharmacologic interventions.
Green Synthesis of Copper Nanoparticles Using a Hydroalcoholic Extract of Moringa oleifera Leaves and Assessment of Their Antioxidant and Anti-microbial Activities
Authors: Das Prince Edwin , Abu-Yousef Imad A. , Majdalawieh Amin F. , Narasimhan Srinivasan , Poltronieri Palmiro
Published: November 2019

The synthesis of metal nanoparticles using plant extracts is a very promising method in green synthesis. The medicinal value of Moringa oleifera leaves and the anti-microbial activity of metallic copper were combined in the present study to synthesize copper nanoparticles having a desirable added-value inorganic material. The use of a hydroalcoholic extract of M. oleifera leaves for the green synthesis of copper nanoparticles is an attractive method as it leads to the production of harmless chemicals and reduces waste. The total phenolic content in the M. oleifera leaves extract was 23.0 ± 0.3 mg gallic acid equivalent/g of dried M. oleifera leaves powder. The M. oleifera leaves extract was treated with a copper sulphate solution. A color change from brown to black indicates the formation of copper nanoparticles. Characterization of the synthesized copper nanoparticles was performed using UV-Vis spectrophotometer, FT-IR spectrometer, TEM, SEM, and XRD. The synthesized copper nanoparticles have an amorphous nature and particle size of 35.8-49.2 nm. We demonstrate that the M. oleifera leaves extract and the synthesized copper nanoparticles display considerable antioxidant activity. Moreover, the M. oleifera leaves extract and the synthesized copper nanoparticles exert potent anti-bacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecalis (MIC values for the extract: 500, 250, 250, and 250 μg/mL; MIC values for the cooper nanoparticles: 500, 500, 500, and 250 μg/mL, respectively). Similarly, the M. oleifera leaves extract and the synthesized copper nanoparticles exert relatively more potent anti-fungal activity against Aspergillus niger, Aspergillus flavus, Candida albicans, and Candida glabrata (MIC values for the extract: 62.5, 62.5, 125, and 250 μg/mL; MIC values for the cooper nanoparticles: 125, 125, 62.5, and 31.2 μg/mL, respectively). Our study reveals that the green synthesis of copper nanoparticles using a hydroalcoholic extract of M. oleifera leaves was successful. In addition, the synthesized copper nanoparticles can be potentially employed in the treatment of various microbial infections due to their potent antioxidant, anti-bacterial, and anti-fungal activities.
REDESAIN WEBSITE UPT PERPUSTAKAAN UNIVERSITAS SEBELAS MARET SEBAGAI MEDIA PENDIDIKAN PENGGUNA BAGI PEMUSTAKA
Authors: Satiawardana Tri Hardian
Published: November 2019

Library website is one of the information retrieval media for students who are in the academic environment. Library website thus should adapt to the needs of students especially in conducting research. This study aimed to analyze the effectiveness of the Sebelas Maret University Library website (UNS) as library education media after the redesign. Redesigning the website focuses on how to present the information sources in which the collections of UNS Library either in printed or electronic form exists. The results of the analysis after redesigning the website showed that the use of the website is as expected. This is showed through the statistics of the web pages most frequently accessed, the number of visitors, time spent from new visitors and returning visitors to visit the Library website UNS, user behavior -especially switching between web pages- and device platform used by a visitor to visit the Library website UNS. As a conclusion, after the redesign, UNS Library website is capable of facilitating student learning behavior that is independent, techie and mobile.

Keywords: library website design, user education, user behavior
PEMANFAATAN JURNAL ONLINE PERPUSTAKAAN BPTP YOGYAKARTA
Authors: Titaningsih Dwi , Suharno Suharno
Published: November 2019

The online journal is one of the sources of information from various sources of information availability, available good from the hearts and abroad to get literature review. It is influenced by the development of technology and information wichis increasingly advanced so that information can be obtained easily.Along with advances in information technology (ICT), efforts in obtaining and providing information is not limited to the distance, space, and time. The use of the online journal by researchers and extension workers are rarely used. The use of the online journal by researchersand extension workers are rarely used. Effort to examine the use of online journals was conducted to determine show far the use of the online journal by researchers, extension workers, and other library user in IAIT Yogyakarta. The studies was conducted in September 2015 and arranged in randomized design with 30 respondents. The result of this studies showed that (1) frequency of using journal online are more dominant in one to two times a week wich is done by 22 library user (73,34%), (2) the length of time utilization for accessing online journals most are one to two hours wich is done by 13 library user (43,34%), (3) the level of ability of library user wich using Boolean operator AND, OR, NOT evidently 11 library user does not understand (36,67%), (4) the action to download from the search result conducted by is library user (50%), (5) The access point information in the most preferred search by keyword is done by 21 library user (70%), (6) the purpose of utilizing the online journal access research were 12 library user (40%), (7) completeness of information required by library user perceived by 23 library user (76,66%), (8) accesing online journal wich are mostly done at the work space is as much as 20 library user (66,67%), (9) the domestic online journals are more affractive was choosen by 17 library user (56,66%).

Keywords: benefit of journal, journal online, library user
KONTRIBUSI PERPUSTAKAAN UNIVERSITAS SEBELAS MARET DALAM MENINGKATKAN MINAT MEMBACA MASYARAKAT DI ERA GADGET
Authors: Hermanto Bambang
Published: November 2019

Di era gadget ini membawa perubahan yang pesat dalam kegiatan membaca masyarakat.
Perpustakaan perguruan tinggi sebagai sumber informasi, sumber belajar dan sumber
pengetahuan dapat memperkuat perannya dalam meningkatkan minat baca dan sebagai
sarana mencerdaskan masyarakat. Upaya yang dapat dilakukan oleh Perpustakaan
Universitas Sebelas Maret antara lain : (1). melakukan pendidikan pemakai, (2).
orientasi perpustakaan, (3). library tour, (4). penyebaran brosur perpustakaan, (5).
menerbitkan jurnal ilmiah, (6) magang perpustakaan, (7). pengadakan berbagai
perlombaan di Perpustakaan, (8) memberikan penghargaan kepada pemustaka teraktif,
(9). menambah jam layanan.
Kata kunci : Perpustakaan perguruan tinggi, membaca, mencerdaskan masyarakat
dan era gadget
MOTIVASI MAHASISWA JURUSAN ILMU PERPUSTAKAAN UNTUK MEMANFAATKAN KOLEKSI PERPUSTAKAAN FAKULTAS FISIP SEBAGAI RUJUKAN PERTAMA
Authors: Putri Ayu K.
Published: November 2019

Perpustakaan perguruan tinggi merupakan sumber rujukan yang penting pada dunia
pendidikan, dalam kegiatan belajar, penelitian maupun sebagai informasi tambahan
lainnya. Berbagai koleksi yang ada di perpustakaan digunakan sebagai bahan belajar
juga sebagai acuan dalam mengembangkan ilmu pengetahuan mereka. Selain buku
pegangan perpustakaan fakultas juga memiliki berbagai koleksi yang lain seperti
skripsi dan beberpa koleksi referensi. Tulisan ini dimaksud untuk mengetahui motivasi
mahasiswa ilmu perpustakaan dan informasi tahun 2015 dalam memanfaatkan
koleksi yang ada di perpustakaan fakultas ilmu sosial dan politik sebagai sumber
rujukan pertama. Metode penelitian yang digunakan adalah kualitatif, dengan data
dari wawancara dan hasilnya direduksi, disajikan serta dianalisa. Hasil dari penelitian
ini, mahasiswa untuk datang ke perpustakaan adalah lokasi, dan motivasi pertama
menggunakan koleksi karena koleksi yang dicari berada di perpustakaan tersebut,
serta mudah didapat. Koleksi yang dimiliki mutahir dan penelusuran yang tidak sulit,
selain motivasi utama karena dosen memberikan tugas yang bahan rujukan berada di
perpustakaan fakultas.
Kata kunci : Perpustakaan, Motivasi, Rujukan, Koleksi
PERAN PERPUSTAKAAN DALAM PENINGKATAN MINAT BACA MASYARAKAT
Authors: Anawati Sri
Published: November 2019

Pertumbuhan pengetahuan dan teknologi yang begitu kencang menjadikan informasi
menjadi hal yang penting bagi kehidupan manusia. Dalam mengahadapi hal tersebut
dibutuhkan kemampuan membaca agar dapat menyerap informasi. Membaca
berpengaruh dalam kehidupan manusia, setelah kita membaca berbagai manfaat bisa
kita dapatkan. Untuk membudayakan minat baca masyarakat perlu mendapatkan
perhatian yang intensif dari berbagai pihak antara lain dari para orang tua, sekolah,
pemerintah, masyarakat dan tak ketinggalan perpustakaan. Perpustakaan menjadi
sarana penghubung atau jembatan yang menyambungkan antara sumber informasi
dengan para pemustaka, sehingga keberadaannya sangat penting sebagai sarana media
sumber belajar.
Kata kunci: Minat baca, perpustakaan, membaca
Orthopedic Elective Rotations for the Physician Assistant Student
Authors: Murphy Emily A. , Beck David C. , Cloutier Dagan , Kuchta Jason D. , Peterson Chad H. , Weikert William B. , Lauziere Anneline C.
Published: November 2019

This article explores the most important factors to consider for the success of both students and preceptors during an orthopaedic rotation. The article describes how both students and preceptors can prepare for the rotation. It also discusses the challenges of precepting in the orthopaedic setting and the challenges that a student may face during the rotation in this specialty. Finally, the article describes ways that preceptors can assist students not only in meeting or exceeding these challenges but also by providing advice for students as they prepare for a possible career as an orthopaedic physician assistant.
Percentual de postura de codornas europeias alimentadas com diferentes níveis de lisina utilizando regressão beta
Authors: Silva M.C.S. , Lucena L.R.R. , Holanda M.A.C. , Holanda M.C.R.
Published: November 2019

A criação de codornas para a produção de ovos está se expandindo nos últimos anos, sendo uma boa alternativa para qualidade nutricional da população. A grande procura por ovos de alta qualidade envolve o processo de produção com relevância nas características de peso, cor, integridade da casca e uniformidade. Para explicar o percentual de postura de codornas europeias alimentadas com diferentes níveis de lisina foi utilizado o modelo de regressão beta. O modelo de regressão beta é utilizado para modelar taxas e proporções como no caso do percentual de postura das cordonas. Após ajuste, o modelo apresentou poder de explicação de 96,61%, e identificou como variáveis explicativas para o percentual de posturas das codornas nível de lisina inseridos na dieta, número de ovos por aves alojadas, conversão alimentar e consumo de lisina. Observou-se que a cada incremento do nível de lisina espera-se em média um aumento de 29,3% no percentual de postura, já a cada incremento do número de ovos por ave alojada esta taxa é de 56,5%, enquanto que para cada incremento na conversão alimentar e no consumo de lisina, respectivamente espera-se um decréscimo de 0,3% no percentual de postura das codornas. O modelo de regressão beta se mostrou bastante eficaz quando comparado aos modelos empregados usualmente na modelagem do percentual de postura das codornas europeias.
Óleos essenciais como modificadores da fermentação ruminal em substituição a monensina sódica in vitro
Authors: Antunes Stella L. , Rosa Prates V. , Zubieta A. , Bayer C. , Jardim Barcellos J.O.
Published: November 2019

The objective of this study to evaluate the effect of secondary plant compounds present in essential oils in replacement of monensin on in vitro ruminal fermentation parameters. It was adopted a completely randomized design with nine treatments and four replicates. The treatments were: control (CON), monensin (MON), garlic oil (ALH), cinnamon oil (CAN), clove oil (CRA), mint oil (HOR), juniper oil (JUN), bitter orange oil (LAR), and melaleuca oil (MEL). The in vitro gas technique was used to record total gas production at 4, 8, 12 and 24 h after incubation. MON, CAN and CRA increased gas production Only the garlic and cinnamon treatments reduced the digestibility of organic matter in 20 and 26% in relation to the control treatment. Methane production reduced (P
EVIDENCE ON MONETARY POLICY TRANSMISSION DURING TRANQUIL AND TURBULENT PERIODS
Authors: Nwosu Chioma Peace , Salisu Afees , Hilili Margaret Johnson , Okafor Izuchukwu Ifeanyi , Oji-Okoro Izuchukwu , Adediran Idis
Published: November 2019

This paper evaluates monetary policy transmission in both tranquil and turbulentperiods for Mexico, Indonesia, Nigeria, and Turkey. Using a structural vectorautoregressive model, we find that the effect of structural shocks from supply, demand,and financial sources tend to fizzle out faster for Nigeria and Mexico compared toIndonesia and Turkey. Another important finding is that while monetary authoritiesin Indonesia and Turkey are more responsive to inflation those in Mexico and Nigeriaare more influenced by the exchange rate. We also observe differences in the conductof monetary policy between the tranquil and turbulent periods.
Subsea Water-Treatment System Installed in Pilot Test at Ekofisk
Authors: Feder Judy
Published: November 2019

This article, written by JPT Technology Editor Judy Feder, contains highlights of paper OTC 29552, “Subsea Water Treatment Pilot Testing at the Ekofisk Field in the North Sea,” by Eirik Dirdal, National Oilwell Varco, prepared for the 2019 Offshore Technology Conference, 6–9 May, Houston. The paper has not been peer reviewed. Copyright 2019 Offshore Technology Conference. Reproduced by permission.

A subsea water-treatment system designed to leverage space availability, steady temperatures, lower bacteria levels, and other natural benefits of the seabed environment was successfully installed during pilot testing at the Ekofisk field offshore Norway. After several phases of testing, a full-scale water-treatment module was built and installed, and at the time the complete paper was written, the pilot had moved into the long-term testing phase to determine the system’s viability under North Sea field conditions. According to the author, if the system succeeds, it could drive a major change in injection-water management offshore.

Introduction

The Ekofisk field was originally developed with pressure depletion as the primary drive mechanism. After several decades of production, significant resources are still in place. Limited gas injection and comprehensive water injection have contributed to a substantial increase in oil recovery. Large-scale water injection began in 1987, and has been extended in several phases. Water displacement of the oil has been successful, and the recoverable resources have been adjusted correspondingly upward from the original 17% to an estimated final recovery factor of greater than 50%.

An important factor in the success of a waterflood project is the quality of the injected water. In worst-case scenarios, poor water quality can cause plugging and reservoir souring. Water quality is greatly affected by contaminants such as suspended solids, corrosion products, scale, and bacteria. Controlling corrosion and disinfection of biomass are two major challenges associated with waterflood. The two challenges are linked because oxidants are required to reduce bacterial activities that could lead to microbial-induced corrosion, but the oxidants also promote corrosion.

Joint-Industry Project (JIP) Results

Development of the injection-water treatment system described in the paper began in 2004. Det Norske Veritas’ recommended practice for qualification of new technology has been used throughout the development process. On the basis of successful experimental testing that demonstrated proof of the concept, a JIP supported by several oil and gas majors was launched in 2009. A prototype was built and tested in 65 m of water depth in Oslofjorden, a sheltered environment in a fjord, to verify the water-treatment module’s performance and reliability through seasonal variations in real offshore conditions. Results demonstrated that the treatment method, which combined various electrolysis approaches, provided very good water quality, in many aspects superior to that achieved by topside seawater-treatment plants.
Comparison of intraocular pressure measured by ocular response analyzer and Goldmann applanation tonometer after corneal refractive surgery: a systematic review and meta-analysis
Authors: Zhang Hui , Sun Zhengtao , Li Lin , Sun Ran , Zhang Haixia
Published: November 2019

Background: Accurate measurement of intraocular pressure (IOP) after corneal refractive surgery is of great significance to clinic, and comparisons among various IOP measuring instruments are not rare, but there is a lack of unified analysis. Although Goldmann Applanation Tonometer (GAT) is currently the internationally recognized gold standard for IOP measurement, its results are severely affected by central corneal thickness (CCT). Ocular Response Analyzer (ORA) takes certain biomechanical properties of cornea into account and is supposed to be less dependent of CCT. In this study, we conducted the meta-analysis to systematically assess the differences and similarities of IOP values measured by ORA and GAT in patients after corneal refractive surgery from the perspective of evidence-based medicine.
Methods: The authors searched electronic databases (MEDLINE, EMBASE, Web of science, Cochrane library and Chinese electronic databases of CNKI and Wanfang) from Jan. 2005 to Jan. 2019, studies describing IOP comparisons measured by GAT and ORA after corneal refractive surgery were included. Quality assessment, subgroup analysis, meta-regression analysis and publication bias analysis were applied in succession.
Results: Among the 273 literatures initially retrieved, 8 literatures (13 groups of data) with a total of 724 eyes were included in the meta-analysis, and all of which were English literatures. In the pooled analysis, the weighted mean difference (WMD) between IOPcc and IOPGAT was 2.67 mmHg (95% CI: 2.20~3.14 mmHg, p < 0.0001), the WMD between IOPg and IOPGAT was -0.27 mmHg (95% CI: -0.70~0.16 mmHg, p = 0.2174). In the subgroup analysis of postoperative IOPcc and IOPGAT, the heterogeneity among the data on surgical procedure was zero, while the heterogeneity of other subgroups was still more than 50%. The comparison of the mean difference of pre- and post-operative IOP (∆IOP) was: mean-∆IOPg > mean-∆IOPGAT > mean-∆IOPcc.
Conclusions: IOPcc, which is less dependent on CCT, may be more close to the true IOP after corneal refractive surgery compared with IOPg and IOPGAT, and the recovery of IOPcc after corneal surface refractive surgery may be more stable than that after lamellar refractive surgery.