bluuebunny/crossref_metadata_2025 huggingface dataset:
Construct Validity of The Nijmeegse Schoolbekwaamheids Test (NST)
Authors: Tarigan Medianta , Fadillah
Published: August 2022

This study aims is to provide construct validity information about the psychometric properties of the Nijmeegse Schoolbekwaamheids Test (NST). NST is one of the instruments that is widely used to measure school readiness. The NST has 10 subtests in the form of pictures and stories that were adapted from the Netherlands. This study involved 471 pre-school students aged 4-6 years. This study used IRT to determine the quality of each item, Exploratory Factor Analysis to determine the new factors formed from the 10 available subtests, and Confirmatory Factor Analysis to determine to construct validity. The IRT 3PL model showed that all items in the NST are valid, but it is necessary to review several items, especially in subtest 10. In the EFA factor analysis, 4 new factors were found that measure the level of factor: logic reasoning ability, memory, fine motor skill, and conceptual maturity in children. These are valid and reliable as evidenced by the RMSEA value on the CFA of 0.05 and the reliability value of 0.87.
The First Description of Acute Compartment Syndrome, by Al-Zahrawi
Authors: Aslanabadi Arash , Zare Zakieh , Aslanabadi Majid
Published: August 2022

Acute compartment syndrome (ACS) is defined as increased pressure within a confined compartmental space, leading to a decline in the perfusion pressure of the tissue within that compartment. To date, the commonly held belief has been that ACS was first described by Richard von Volkmann in 1881. However, we propose that ACS was originally described by Abul Qasim Al-Zahrawi approximately 900 years earlier.
SAGE-PEDD user manual
Authors: Wenren Yonghu , Allen Luke , Haehnel Robert
Published: August 2022

SAGE-PEDD is a computational model for estimating snowdrift shapes around buildings. The main inputs to the model are wind speed, wind direction, building geometry and initial ground or snow-surface topography. Though developed mainly for predicting snowdrift shapes, it has the flexibility to accept other soil types, though this manual addresses snow only. This manual provides detailed information for set up, running, and viewing the output of a SAGE-PEDD simulation.
bioéconomie en France. Une étude scientométrique
Authors: Duquenne Marianne , Schöpfel Joachim , Dumeignil Franck , Prost Hélène
Published: August 2022

Dans le cadre d’une recherche sur l’application des principes de la science ouverte au domaine de la bioéconomie, nous avons mené une étude scientométrique de la production scientifique de la France dans ce domaine, pour la période de 2015 à 2019. L’étude a permis d’identifier 1913 publications dans la base de données Scopus. Nous avons analysé ce corpus sous différents aspects : types et sources des documents, avec volumétrie et impact ; auteurs, organismes et établissements ; sources de financement ; degré d’internationalité et taux d’ouverture (libre accès). La discussion porte sur la terminologie et les sources d’une telle étude scientométrique, sur l’accessibilité des publications et sur la position de la France dans ce domaine. La conclusion propose quelques recommandations pour la conduite d’une étude similaire, notamment à destination des professionnels de l’information.
Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Authors: Delgado-Diaz David Jose , Jesaveluk Brianna , Hayward Joshua A. , Tyssen David , Alisoltani Arghavan , Potgieter Matthys , Bell Liam , Ross Elizabeth , Iranzadeh Arash , Allali Imane , Dabee Smritee , Barnabas Shaun , Gamieldien Hoyam , Blackburn Jonathan M. , Mulder Nicola , Smith Steven B. , Edwards Vonetta L. , Burgener Adam D , Bekker Linda-Gail , Ravel Jacques , Passmore Jo-Ann S. , Masson Lindi , Hearps Anna C. , Tachedjian Gilda
Published: August 2022

Background: Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at reduced risk of acquiring sexually transmitted infections including HIV but the biological mechanisms involved remain poorly defined. Here we performed metaproteomics on vaginal swab samples from young South African women (n=113) and transcriptomics analysis of cervicovaginal epithelial cell cultures to examine the ability of lactic acid, a metabolite produced by cervicovaginal lactobacilli, to modulate genital epithelial barrier function. Results: Compared to women with Lactobacillus-depleted microbiota, women dominated by vaginal lactobacilli exhibit higher abundance of bacterial lactate dehydrogenase, a key enzyme responsible for lactic acid production, which is independently associated with an increased abundance of epithelial barrier proteins. Physiological concentrations of lactic acid enhance epithelial cell culture barrier integrity and increase intercellular junctional molecule expression. Conclusions: These findings reveal a novel ability of vaginal lactic acid to enhance genital epithelial barrier integrity that may help prevent invasion by sexually transmitted pathogens.
An Optimized Deep Features Based Intrusion Detection Framework for the Wireless Networks
Authors: Majjaru ChandraBabu , K Senthilkumar
Published: August 2022

Nowadays, Internet-of-things (IoT) facilities have been used worldwide in all digital applications. Hence, maintaining the IoT communication system's security range is crucial to enrich the IoT advanced better. However, the harmful attacks can destroy security and degrade the IoT communication channel by making network traffic, system shutdown, and collapse. The present work has introduced a novel Frog Leap-based Hyper-parameter Tuned Deep Neural (FLbHTDN) model to overcome these issues to detect intrusion in the IoT communication paradigm. Hence, the dataset called Nsl-Kdd has been utilized to validate the pressed model. Initially, the preprocessing process functioned to remove the error from the trained dataset. Consequently, the present features in the dataset have been tracked, and the malicious features have been extracted and classified as specific attack classes. The designed model is executed in the Java platform, and the improvement measure of the developed technique has been validated by performing the comparative analysis. The proposed FLbHTDN approach has obtained the finest attack prediction score in less duration than the compared models.
Outcome and learning curve for laparoscopic intra-corporeal inguinal hernia repair in children
Authors: Fung Adrian Chi Heng , Chan Ivy Hau Yee , Wong Kenneth Kak Yuen
Published: August 2022

Background
Laparoscopic inguinal hernia repair is one of the procedures most commonly performed by paediatric surgeons. Current research on the learning curve for laparoscopic hernia repair in children is scarce. This study aims to evaluate the clinical outcome and learning curve of laparoscopic intra-corporeal inguinal hernia repair in children.
Methods
A retrospective single-centre analysis of all paediatric patients who underwent laparoscopic intra-corporeal inguinal hernia repair between 2010 and 2019 was performed. The clinical outcomes were analysed. The data on the achievement of the learning curve by surgical trainees were evaluated with the CUSUM technique, focusing on operative time.
Results
There were 719 patients with laparoscopic intra-corporeal inguinal hernia repair (comprising 1051 sides) performed during the study period. The overall ipsilateral recurrence rate was 1.8% without other complications detected. CUSUM analysis showed that there were 3 phases of training, for which the trainees underwent initial learning phase (Phase 1) for the first 7 cases. After mastering of the skills and extrapolating the skills to male patients with smaller body size (Phase 2), they then achieved performance comparable to that of the senior surgeons after 18 procedures (Phase 3).
Conclusions
18 procedures seem to be the number required to reach the learning curve plateau in terms of operative time by surgical trainees. The clinical outcomes show that laparoscopic intra-corporeal inguinal hernia repair is a safe and transferrable technique, even in the hands of trainees, with adequate supervision and careful case selection. It also provides skill acquisition for minimally invasive surgery.
Usefulness of the Combination of FilmArray and procalcitonin in respiratory infections in the Pediatric Intensive Care Unit
Authors: Gonzalez Carolina Bonilla , Camargo-Agón Laura , Barrera Pedro Alexander , Rodríguez Sebastián Peña , Chain Alejandra Mal , Uribe Camila , Vera-Chamorro Jose Fernando
Published: August 2022

Introduction. Acute respiratory infections represent one of the main causes of preventable infant mortality and morbidity in children, and although a significate proportion of cases are of viral etiology, antibiotic treatment is the overly-excessive norm. Studies suggest that the combined use of serum procalcitonin (PCT) and polymerase chain reaction (PCR) multiplex (FilmArray) may be used to guide antibiotic therapy. Methods. A prospective cohort study was conducted of patients between 1 month and 17 years of age with acute respiratory infection hospitalized in the PICU with a negative viral panel report and both respiratory FilmArray and procalcitonin performed in the first 72 hours of hospitalization. A diagnostic algorithm was then applied to these patients, tailored to the result of both tests. Results. Of the total 326 patients recluted, 110 met the inclusion criteria; 23 patients were excluded for infections other than respiratory origin. Of the 87 remaining patients, all had a respiratory FilmArray performed prior to the PCT sample, demonstrating a diagnostic yield of over 80%. Procalcitonin was requested in slightly more than half of the patients and was positive in a third of these cases. When combined in the diagnostic algorithm, FilmAray and PCT lead to changes in treatment plan in 30% of patients in terms of antibiotic management prescribed on admission, with the most frequent treatment plan change being suspending the antibiotic altogether (from 41.4% to 10.3%, for a total of 89.7% of patients without antibiotic therapy following the algorithm. None of the patients died and only 1/87 patients required re-initiating antibiotics after having suspended treatment. The interaction between the identification of a viral pathogen in the FilmArray and a negative PCT result yielded statistically significant results (p=0.004) and affected the change in treatment management mainly in antibiotic discontinuation.Conclusions. The combined use of FilmArray and serum PCT as tools in the diagnostic algorithm is a safe way to guide tailored antibiotic therapy in pediatric patients with ARI in critical state.
Manufacturing agglomeration, urban form and haze pollution
Authors: Wei Jishi , Ye Yunling , Yu Haichao
Published: August 2022

Manufacturing agglomeration promotes rapid economic development while also causing severe environmental pollution. This paper investigates the impact and mechanism of manufacturing agglomeration on haze pollution from the Chinese city level. Furthermore, we discuss the moderating effect and threshold effect of the three urban forms of urban external shape complexity, urban compactness, and urban fragmentation on the relationship between the two. The result shows: (1) The aggregation of the manufacturing industry presents an inverted U-shaped characteristic of promoting first and then inhibiting haze pollution in China's overall, eastern and central regions. (2) The complexity of the city's external shape and the city's fragmentation has a positive moderating effect on the relationship between manufacturing agglomeration and haze pollution. And urban fragmentation shows a negative moderating effect on the relationship between the two when the level of manufacturing agglomeration is on the right side of the inverted U-shaped curve. (3) The urban form shows a significant double threshold characteristic for haze pollution, increasing the complexity of the city's external shape and the city's fragmentation. The agglomeration of manufacturing shows the characteristics of first inhibiting and then promoting haze pollution. As urban compactness increases, the inhibitory effect of manufacturing agglomeration on haze pollution increases.
Degradation of cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) using ozone process: influencing factors and mechanism
Authors: Yan Boyin , Han Chunyu , Liu Zhiquan , Wu Guizhi , Wang Songxue , Li Jincheng , Xia Wenxiang , Cui Fuyi
Published: August 2022

β-N-methylamino-L-alanine (BMAA) is a new kind of cyanobacterial neurotoxin, which is widely present in water sources contaminated by algae and may threaten human health through drinking water. The ozone process is an advanced water treatment process widely used in drinking water treatment plants. In this work, the effectiveness of ozone oxidative degradation of BMAA was systematically explored, and the effect of operating parameters on the effectiveness of ozone oxidative degradation of BMAA was investigated, and the degradation mechanism of ozone oxidative degradation of BMAA was speculated. The results showed that BMAA could be quickly eliminated by ozone, and the removal rates of BMAA were nearly 100% in pure water, but the removal rates were reduced in actual water. BMAA was primarily degraded by direct oxidation of ozone molecules in acidic and near-neutral conditions, and indirect oxidation of •OH accounted for the main part under strong alkaline conditions. The pH value had a significant effect on the decomposition of BMAA, and the degradation rate of BMAA was fastest at near neutral pH value. The degradation rates of TOC were significantly lower than that of BMAA, indicating that by-products were generated during the degradation process. Three by-products ([M-H]+ = 105, 90 and 88) were identified by UPLC-MS/MS and the degradation pathways of BMAA were proposed. The production of by-products was attributed to the fracture of the C-N bonds. This work is helpful for the in-depth understanding on the mechanism and demonstration of the feasibility of the oxidation of BMAA by the ozone process.
Angiotensin II-pretreated hucMSCs attenuate inflammation and reverse pulmonary fibrosis in SD rat lung
Authors: Wang Wei , Song Aishi , Deng Weiyue , Zhang Yuying , Mukama Omar , Habimana Jean de Dieu , Xie Wei , Zhou Peng , Li Amy L. , Li Jiaxing , Deng Sihao , Ni Bin , Peng Kexin , Zhang Shusheng , Yan Xiaoxin , Huang Jufang , Li Zhiyuan
Published: August 2022

Background: Pulmonary fibrosis (PF) is an irreversible disease with a poor prognosis and a serious impact on patients' health. PF is also associated with COVID-19, especially in immunocompromised people. Herein, efforts have been made to treat PF using pretreatment of human umbilical cord mesenchymal stem cells (hucMSCs) with angiotensin II (Ang II) as a novel therapeutic method. Methods: PF model of Sprague Dawley (SD) rats were established by tracheal injection of bleomycin (BLM) (5U/Kg). On day 15 after modeling, PBS, hucMSCs or hucMSCs-Ang II were injected into tail vein. On the 23rd day after modeling, samples were taken and corresponding indexes were tested.Results: Our results first showed that Ang II pretreatment induced more hucMSCs to reach the injured lung and alleviated pulmonary fibrosis. Transplantation of hucMSCs-Ang II reduced inflammatory infiltration, increased IL-10 expression and enhanced macrophage matrix-metallopeptidase-9 (MMP-9) expression for collagen degradation. Moreover, the Ang II-treated hucMSCs decreased hydroxyproline (HYP) and alpha-smooth muscle actin (α-SMA) expression in SD rats and promoted collagen and collagen fiber degradation.Conclusions: Ang II pretreatment enhanced the homing ability of hucMSCs, and hucMSCs-Ang II transplantation reversed PF by inhibiting inflammation and promoting collagen and collagen fiber degradation, promising its clinical application in the treatment of post-inflammatory PF caused by various disorders, including COVID-19 and related pneumonia.
Operando Spectroscopic Insight into the Synergistic Catalysis on Dual-hetero-atom Sites in Zinc-air Battery
Authors: Sun Zhiguo , Zhang Huijuan , Cao Linlin , Ru Sen , Liu Xiaokang , Wu Dan , Shen Xinyi , Zhang Xue , Chen Zihang , Luo Qiquan , Xu Faqiang , Yao Tao
Published: August 2022

The construction and understanding of synergy in well-defined dual-atom active sites is an available avenue for promoting the multistep tandem catalytic reaction. Herein, guiding by the theoretical screening, we construct a dual-hetero-atom catalyst that comprises adjacent Cu-N4 and Se-C3 active sites for high-efficiency Zn-air battery. Device-based operando X-ray absorption spectroscopy coupled with theoretical calculations provide in-depth insights into this dual-atom synergy mechanism during realistic Zn-air battery operation conditions. We demonstrate that foreign-heteroatom Se modulators can efficiently polarize the charge distribution around symmetrical Cu-N4 moieties, and serve as the synergistic site to facilitate the second oxygen reduction step, in which the key OOH*-(Cu1-N4) transforms to O*-(Se1-C2) intermediate on the dual-hetero-atom sites after gaining one electron. As a result, the Se modified dual-hetero-atom catalyst achieves ultrahigh ORR activity with a half-wave potential of 0.905 V vs. RHE and a maximum output power density of 206.5 mW cm-2 in Zn-air battery.
Optimization of Array System Configuration Using the Smoothed-Pad Algorithm
Authors: Batubara Mario , Manik Timbul , Sitompul Peberlin , Lathif Muthofa
Published: August 2022

The source of astronomical objects, in general, is a very far distance from the observation instrument so that the transmitted signal is received very small and is at risk of being disturbed by other sources around the receiving system. Therefore, the concept of multiple receivers with array interferometry configuration arrays is used to improve the quality of the source signal detected by the receiving system. The position of each receiving system, known as the antenna pad, determines the quality performance of the received signal output. The antenna positions are arranged in a discrete grid system so that there is a vacancy between antenna pads. In this paper, a computational technique is present to overcome the region’s emptiness between one antenna to its neighbor. As an initial result, the integrating of each position with its neighboring pads with some of its smoothing functions is optimal in filling the void region and maximizing the u-v coverage.
Based annual classification of precipitation fallow period in dryland the Loess Plateau of China
Authors: Noor Hafeez , Min Sun , Li· Tingliang , Gao Zhiqiang
Published: August 2022

In order to clarify the relationship between wheat yield and precipitation in dryland region, the annual classification method of precipitation in fallow period was summarized in this paper by analyzing precipitation, precipitation distribution and its relationship with yield in Wenxi Experimental Base of Shanxi Province and major meteorological stations on the Loess Plateau from 1983 to 2020.The results showed that the average precipitation during fallow period was 296mm (coefficient of variation CV=10%), accounting for 58% (coefficient of variation CV=6%) of annual precipitation in the upland region of the Loess Plateau. With the increase of precipitation in fallow period, the wheat yield in dryland increased logarithmically (Y =2526.5 lnX-10148, R2=0.42, P<0.05). The method of annual classification of precipitation in fallow period. Divide the year type by annual precipitation, wet year: Pi>Pm + 0.33δ; Pm-0.33 δ≤ Pi ≤ Pm + 0.33δ; Dry years: Pi< Pm-0.33 δ, Pi was annual precipitation (mm); Pm is perennial average annual precipitation (mm); δ is mean variance of annual precipitation (mm). The proportion of perennial and humid fallow precipitation was lower than the multi-year average were defined as abnormal years, and the years in which the proportion of arid fallow precipitation was higher than the multi-year average were defined as abnormal years.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer in an Australian institution: Lessons from 20 years' experience
Authors: Farrell Rhonda , Liauw Winston , Morris David
Published: August 2022

Objectives: We report the 20-year experience of the largest Australian unit performing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer and reflect on learning opportunities. Methods: A retrospective review of all cases of CRS for ovarian cancer at St George Peritonectomy Unit from Jan 1998- Jan 2018 was performed. Prospectively collected data include age, stage, histology, disease extent (PCI), completeness of cytoreduction (CC score), HIPEC regime, 30-day surgical morbidity, disease recurrence, and death. Survival was computed using Kaplan-Meier method and analysed using log-rank tests and Cox-proportional hazards models. Results: Forty-one women with advanced ovarian cancer (11 primary stage III/IV, 30 recurrent) underwent CRS, 29 (71%) with HIPEC. Most (68%) had high-volume disease (PCI >15). In 98%, CC0/CC1 (residual <2.5mm) was achieved. Fourteen (34%) had grade 3/4 complications, 1 patient (2%) died within 30 days and 2 patients (5%) died within 90 days. Progression-free and median overall survival was 30.0 and 67.0 months for primary cancer, and 6.7 and 18.1 months for recurrent cancer. Survival was associated with platinum-sensitivity, PCI£15, and CC score 0, but not HIPEC. Conclusion: This study reports outcomes for patients with advanced ovarian cancer patients treated in an Australian centre offering CRS and HIPEC. Whilst survival and morbidity outcomes were good for primary disease, they were poorer than predicted from the literature for cases of recurrent disease. The incorporation of evidence-based predictors of survival and multidisciplinary input are essential to achieve the best survival outcomes.
Dissemination and Genome Characterization of a Human Adenovirus F41 in a Patient with B-Cell Lymphoma
Authors: Fall Amary , Campodonico Victoria L. , Howard Craig , Gallagher Nicholas , Bailey Gabrielle , Kajon Adriana E. , Mostafa Heba H.
Published: August 2022

Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, a fifty-eight-year-case with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemotherapy was diagnosed with disseminated adenovirus infection. HAdV DNA was quantified in stool, plasma, and urine with viral loads of 7, 4, and 3 log10 copies/mL, respectively. The patient’s course was rapidly progressive and he passed away 2 days after initiation of antiviral therapy. The patient’s infecting virus was characterized as HAdV-F41 by whole genome sequencing.
Cross-sectional uncertainties influences on sensitivity studies of DUNE and T2HK experiments
Authors: Devi Ritu , Singh Jaydip , Potukuchi Baba
Published: August 2022

The ultimate objectives of ongoing and upcoming neutrino experiments are the precise measurement of neutrino mixing parameters and the confirmation of mass hierarchy. The systematic inaccuracy in the cross-section models introduces inaccuracy in the neutrino mixing parameters
estimation. It is important to secure a large decrease of uncertainties, particularly those relating to cross-section, neutrino-nucleus interactions, and neutrino-energy reconstruction, in order to achieve these ambitious goals. In this research article, we use three alternative neutrino event
generators, GENIE, NuWro, and GiBUU, to analyze sensitivity studies of T2HK, DUNE, and combined sensitivity of DUNE, and T2HK for mass hierarchy, CP violation, and octant degeneracy caused by cross-section uncertainties. The cross-section models of these generators are separate
and independent.
Local environment drives rapid shifts in composition and phylogenetic clustering of seagrass microbiomes
Authors: Kardish Melissa , Stachowicz John
Published: August 2022

Plant microbiomes depend on environmental conditions, stochasticity, species, and genotype identity. Eelgrass (Zostera marina) is a unique system for plant-microbe interactions as a physiologically-challenged, marine angiosperm growing in anoxic sediment, periodic exposure to air at low tide, and gradients in water clarity and flow. We tested the influence of host origin versus environment on microbiome composition by transplanting 768 plants among four sites within Bodega Harbor, CA. Over three months following transplantation, we sampled microbial communities monthly on leaves and roots and sequenced the V4-V5 region of the 16S rRNA gene to assess community composition. The main driver of leaf and root microbiome composition was destination site; more modest effects of origin site did not last over a month. Community phylogenetic analyses suggested that environmental filtering structures these communities, but the strength and nature of this filtering varies among sites and over time. We demonstrate that local environmental differences create rapid shifts in associated microbial community composition with potential functional implications for hosts under shifting environmental conditions.
Study on Amino-functionalized Porous Carbon Materials for MB and Cr (VI) Adsorption
Authors: Song Jie , Chen Lijun , Niu Yuhua , Han Yuying , Sun Yonghui
Published: August 2022

From the perspective of environmental protection, high removal rate, reusability and degradability, Amino-functionalized porous hydrogel material P-(EA-β-CD/KHA/AC) was synthesized by introducing ethylamino cyclodextrin, humic acid and activated carbon, using polyacrylic acid as the carrier. The gel materials before and after adsorption were characterized by FTIR, XRD and XPS. The removal of organic matter (MB) and heavy metal ions (Cr (VI)) showed high adsorption capacity. At 298K and pH 8, the adsorption capacity of P-(EA-β-CD/KHA/AC) hydrogel for MB and Cr (VI) was as high as 262.31mg/g, 170.12mg/g, and the removal rate was 98.96% and 70.27%. The adsorption behavior follows the pseudo-second-order kinetic equation, conforming the Langmuir model, and through intermolecular forces, π-π conjugation, chelation and other interactions, an entropy-increasing, endothermic, and spontaneous process is formed. The regeneration and degradability experiments of P-(EA-β-CD/KHA/AC) hydrogel were carried out, verified that it has recycling performance, the weight loss rate of degradation in water and acid-base buffer solution for 6 months reached 45.82%, 28.25% and 30.70%, respectively.
Malicious Attack Classification Based-on Continuous Hidden Markov Models in Wireless Sensor Networks
Authors: SATORI Hassan , Boutazart Youssef , Abderahim Ezzine , satori Khalid
Published: August 2022

Alongside the rapid progress of Wireless sensor networks (WSNs) technologies, sensors and networks can rapidly be victim of distributed attacks. Attackers can perform intrusions to breakdown the network during the routing process, intercept gathered data by dropping or re-sharing them. To avoid the increasing of security issues, many attack identification models were proposed in WSNs in which detection systems are deployed to collect sensed data and categorize them using machine learning and stochastic

binary-classification techniques. In this work, a new method is introduced to analyze and classify WSN dataset. We aim to design an anomaly identification approach to improve the sensor network security, it efficiency with high accuracy. To reach this goal, machine learning approaches are used to define a detection system which learn from routing dataset to identify network malicious entries.

The proposed models is based on Hidden Markov Model (HMM), Gaussian Mixture Model (GMM) stochastic assumptions. Also, dimensionality reduction technique was deployed to select the most relevant features for training. The experimentation phase was realized on own made dataset reflecting different network situations of normal and attacked cases. The outcomes performances of the proposed method were obtained with classification accuracy of 92.18% using 2HMM/3GMMclassifier. This result demonstrate the quality of our proposed approach compared with existing literature and its usefulness to improve the security of WSN.
Development of 3D body shape creation methodology for obesity information and body shape management for tracking body condition check: body type in their 20s and 30s
Authors: Kim Changgyun , Youm Sekyoung
Published: August 2022

This paper demonstrates how to generate a three-dimensional (3D) body model through a small number of images and derive body values ​​similar to the actual values ​​by using the generated 3D body data. In this study, a 3D body model that can be used for body type diagnosis was developed using two full-body pictures of the front and side taken with a mobile phone. For data learning, 400 3D body datasets (male: 200, female: 200) provided by Size Korea were used, and four models, i.e., 3D recurrent reconstruction neural network, point cloud generative adversarial network, skinned multi-person linear model, and pixel-aligned impact function for high-resolution 3D human digitization, were used. The models proposed in this study were analyzed and compared. Total 10 men and women were analyzed, and their corresponding 3D models were verified by comparing the 3D body data derived from 2D image inputs with those obtained using a body scanner. The model was verified through the difference between the 3D data derived from the 2D image and those derived using an actual body scanner. Unlike the 3D generation models that could not be used to derive the body values in this study, the proposed model was successfully used to derive various body values, indicating that this model can be implemented to identify various body types and monitor obesity in the future.
Paternal genetic diversity, differentiation and phylogeny of three white yak breeds/populations in China
Authors: Luo Jing , Wei Xudong , Liu Wenxian , Chen Shengmei , Ahmed Zulfiqar , Sun Wenping , Lei Chuzhao , Ma Zhijie
Published: August 2022

The white yak, a unique and valuable farm animal of the Qinghai-Tibetian Plateau, is mainly distributed in Tianzhu (County of Gansu Province), Menyuan, Huzhu and Ledu (three Counties of Qinghai Province) in China. In the present study, the Y-chromosomal based genetic diversity, differentiation and phylogeny of three Chinese white yak breeds/populations (Tianzhu, Huzhu and Menyuan) were comprehensively explored using five Y-SNPs (SRY4, USP9Y, UTY19, AMELY3 and OFD1Y10) and one Y-STR (INRA189) markers. The results of this study showed that six Y-haplotypes (H1Y1, H9Y1, H10Y1, H11Y2, H12Y2 and H13Y2) were identified in 97 male yaks from three white yak breeds/populations. Among haplotypes, H1Y1, H10Y1 and H11Y2 were shared haplotypes for all of breeds/populations and H12Y2 was shared by Tianzhu and Huzhu populations. However, H9Y1 and H13Y2 haplotypes were only detected in Menyuan and Tianzhu white yak populations, respectively. The Y-haplotype diversity was maximum in Huzhu white yak (0.7500±0.0349), the medium in Tianzhu white yak (0.6881±0.0614) and lowest in Menyuan white yak (0.5720±0.0657), respectively. The total Y-haplotype diversity of three white yak breeds/populations was 0.7567±0.0233, indicating rich paternal genetic diversity in white yak. The FST values showed a moderate differentiation between Tianzhu and Menyuan (FST =0.0763, P<0.05) populations, weak differentiation between Huzhu and Tianzhu white yak breeds/populations (FST =0.0186, P>0.05) and Huzhu and Menyuan (FST =-0.005, P>0.05) populations. The clustering analysis showed a close genetic relationship between Huzhu and Menyuan white yaks and far from Tianzhu white yak breed. The phylogenetic analyses showed that white yak had two Y-haplogroups/lineages (Y1 and Y2) with two potential paternal origins. The data of present study could contribute to the conservation and utilization of special white yak genetic resources.
Baicalein inhibits renal cancer cell growth and metastasis via ERK and p38 pathway
Authors: Guo Zhaoxin , Liu Tianyu , Lv Renguang , Zhang Yongzhen , Meng Liwei , Zhou Zunlin , Liu Zhaoxu , Yan Lei
Published: August 2022

Background
Baicalein has exhibited anti-tumor effects against several cells of different origins. However, the potential effects of baicalein on renal cancer has not been investigated.
Methods
Human A498 and 786-O cell lines were used to investigate the antirenal acitivity of baicalein. CCK-8 assay was used to detect cell viability. Cell migration was assessed by scratch assay and transwell migration assay in vitro. Transwell invasion assay was carried out to evaluate the effect of baicalein on cell invasion. Apoptosis assay was performed to detect cell apoptosis using the Annexin V-FITC/PI apoptosis detection kit. The protein expression of ERK, p-ERK, p38, p-p38, p53, bax, bcl-2 and survivin were measured by WB assay.
Results
Baicalein significantly inhibited the proliferation of A498 and 786-O cells in a time- and dose-dependent manner. The similar effect of baicalein on cell migration, invasion and cell apoptosis were observed. Mechanismlly, ERK and p38 MAPK pathways account for the anti-tumor effects of baicalein.
Conclusions
Baicalein can induce apoptosis and inhibit metastasis of renal caner cells through inhibition of the ERK and p38R pathway.
The association between the shoulder abductor strength and the tracheostomy in patients with traumatic cervical spinal cord injury
Authors: Jian Yunbo , Mu Zhiping , Sun Dawei , Zhang Dan , Zhang Zhengfeng
Published: August 2022

Background
Early prediction of tracheostomy in traumatic cervical spinal cord injury (TCSCI) patients is often difficult. This study aims to clarify the association between the shoulder abductor strength (SAS) and the tracheostomy in patients with TCSCI.
Methods
We retrospectively analyzed 513 TCSCI patients who were treated in our hospital. Patients were divided into two groups according to whether they had undergone a tracheostomy. Potential predictors were assessed for their association with tracheostomy in patients. A nomogram was developed based on multivariable logistic regression analysis (MLRA) to visualize the predictive ability of the SAS. Validation of the nomogram was performed to judge whether the nomogram was reliable for visual analysis of the SAS. Receiver operating characteristics curve, specificity, and sensitivity were also performed to assess the predictive ability of the SAS.
Results
The proportion of patients with the SAS grade 0–2 was significantly higher in the tracheostomy group than in non-tracheostomy group (88.1% vs. 54.8%, p = 0.001). The SAS grade 0–2 was identified as a significant predictor of the tracheostomy (OR: 4.505; 95% CI: 2.080–9.758; p = 0.001). Points corresponding to both the SAS grade 0–2 and the neurological level of injury at C2-C4 were between 60 and 70 in the nomogram. The area under the curve for the SAS grade 0–2 was 0.692. The sensitivity of SAS grade 0–2 was 0.239. The specificity of SAS grade 0–2 was 0.951.
Conclusions
The SAS is a novel predictor of tracheostomy in patients after TCSCI. The SAS grade 0–2 had a good predictive ability of tracheostomy.
Exploitation of indigenous knowledge to control gastrointestinal nematodes in cattle during droughts
Authors: Kamba Evelyn Tatenda , Chimonyo Michael
Published: August 2022

Gastrointestinal nematodes (GIN) exacerbate the impact of droughts on the survival of cattle. Because of the inadequacies of conventional system, it is becoming increasingly important to explore indigenous knowledge systems to create drought tolerant herds through GIN control. The objective of the study was to explore the indigenous methods of GIN control during droughts. Face-to-face interviews with experts on indigenous knowledge were conducted to give insight on importance, methods and ranking of GIN control. The experts sampled 86 cattle that were used to test their assertions. The control methods used were; identification of susceptible cattle using predisposing factors, diagnosis of GIN burdens using faecal appearance and treatment using phytotherapy. Experts ranked predisposing factors as the most important control strategy and identified body condition, class, sex, coat colour, pregnancy status and lactation status as predisposing factors to high GIN burdens. Thin, older, dark coloured cattle as well as pregnant and lactating cows were considered susceptible. Pregnancy status, coat colour and sex, however, were significantly associated to high GIN burdens. Females were 2.6 times more likely to have high GIN burdens as opposed to males. Dark coloured cattle were 3.5 times more likely to have high GIN burdens as compared to light coloured ones and likelihood of pregnant cows was 4.9 times higher than non-pregnant cows. A dark coloured pregnant cow was extremely susceptible to high GIN burdens. Knowledge of predisposing factors informed selection decisions when purchasing foundation stock. Susceptible animals were prioritized during droughts or culled where resources were scarce.
The relationship between glycemic status and the risk of third, fourth, and sixth cranial nerve palsy: a nationwide population-based study (2009-2018)
Authors: Lee Chaeyeon , Han Kyung Do , Yoo Juhwan , Park Kyung-Ah , Oh Sei Yeul
Published: August 2022

Abstract: The incidence of diabetes is increasing globally and prediabetes is clinically important. However, the relationship between diabetic duration and ocular motor cranial nerve palsy (CNP) was not evaluated in large scale study and studies on ocular motor CNP in pre-diabetes are sparse.Backgroud/Objectives: This study aimed to assess the association between glycemic status and the incidence of ocular motor CNP.Subjects/Methods: This is a retrospective nationwide population-based cohort study using National Health Insurance Service (NHIS) of South Korea data from 2009. Health checkup data of 4,067,842 individuals aged between 20 and 90 years between January 1, 2009, and December 31, 2018, were analyzed. The subjects were classified based on glycemic status as nondiabetes, impaired fasting glucose (IFG), newly detected diabetes, diabetes duration <5 years, and diabetes duration ≥5 years. The primary end point of this study was incidence of CNP. Hazard ratio (HR) and 95% confidence interval (CI) of CNP were estimated using Cox proportional hazards regression analysis. Model 3 adjusted age, sex, smoking status, alcohol consumption, physical activity of individuals and body mass index in the analysis. Results: We identified 5,835 incident CNP cases and 4,062,007 control cases during the follow-up period (average, 6.3 years). In the adjusted model 3, the adjusted HR for the IFG group was 1.104 (95% CI 1.035 - 1.177), for the newly detected diabetes group was 1.793 (95% CI 1.6 - 2.009), for the diabetes duration <5 years group was 1.959 (95% CI 1.768 - 2.169) and for the diabetes duration ≥5 years group was 2.606 (95% CI 2.38 - 2.854). Using the Kaplan-Meier curve, the log-rank test showed increase in the incidence of CNP according to the duration of diabetes (p < 0.001).Conclusions: Our population-based large-scale cohort study suggests that both IFG and diabetes significantly increased the risk of the development of ocular motor CNP compared to the normal glycemic status.
An LTR Retrotransposon Insertion inside CsERECTA for an LRR Receptor-like Serine/threonine-Protein Kinase Results in compact (cp) plant architecture in cucumber
Authors: Chen Feifan , Yong Jianpeng , Liu Mengying , Wang Qiqi , Zhong Huili , Pan Yupeng , Chen Peng , Weng Yiqun , Li Yuhong
Published: August 2022

The compact (cp) phenotype in cucumber (Cucumis sativus L.) is an important plant architecture-related trait with a great potential for cucumber improvement. In this study, we conducted map-based cloning of the cp locus, identified and functionally characterized the candidate gene. Comparative microscopic analysis suggested that the short internode in the cp mutant is due to fewer cell numbers. Fine genetic mapping delimited cp into an 8.8-kb region on chromosome 4 harboring only one gene, CsERECTA (CsER) that encodes a leucine rich repeat receptor-like kinase. The insertion of a 5.5-kb insertion of along terminal repeat retrotransposon in the 22nd exon resulted in loss-of-function of CsER in the cp plant. Spatiotemporal expression analysis in cucumber and CsER promoter-driven GUS assays in Arabidopsis indicated that CsER was highly expressed in the stem apical meristem and young organs, but the expression level was similar in the wild type and mutant cucumber plants. However, CsER protein accumulation was reduced in the mutant as revealed by western hybridization. The mutation in cp also did not seem to affect self-association of CsER for formation of dimers. Ectopic expression of CsER in Arabidopsis was able to rescue the plant height of the loss-of-function AtERECTA mutant, whereas the compact inflorescence and small rosette leaves of the mutant could be partially recovered. Transcriptome profiling in the mutant and wild type plants revealed hormone biosynthesis/or signaling, and photosynthesis pathways associated with CsER-dependent regulatory network. Our work from the present study provides new insights for the use of cp in cucumber breeding.
Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury
Authors: huynh tai , Reed Cassandra , Blackwell Zain , Phelps Payton , Herrera Luis C. Pinzon , Almodovar Jorge , Zaharoff David A. , Wolchok Jeffrey C
Published: August 2022

This study was designed to test the hypothesis that in addition to repairing the architectural and cellular cues via regenerative medicine, the delivery of immune cues (immunotherapy) may be needed to enhance regeneration following volumetric muscle loss (VML) injury. We identified IL-10 signaling as a promising immunotherapeutic target. To explore the impact of targeting IL-10 signaling, tibialis anterior (TA) VML injuries were created and then treated in rats using autologous minced muscle (MM). Animals received either recombinant rat IL-10 or phosphate buffered saline (PBS) controls injections at the site of VML repair beginning 7 days post injury (DPI) and continuing every other day (4 injections total) until 14 DPI. At 56 DPI (study endpoint), significant improvements to TA contractile torque (82% of uninjured values & 170% of PBS values), TA mass, and myofiber size in response to IL-10 treatment were detected. Whole transcriptome analysis at 14 DPI revealed activation of IL-10 signaling, muscle hypertrophy, and lymphocytes signaling pathways. Expression of ST2, a regulatory T (Treg) cell receptor, was dramatically increased at the VML repair site in response to IL-10 treatment when compared to PBS controls. The findings suggest that the positive effect of delayed IL-10 delivery might be due to immuno-suppressive Treg cell recruitment.
In situ growth of graphene catalyzed by phase-change material at 400 oC for wafer-scale optoelectronic device application
Authors: Xie Yiyang , Hu Liangchen , Dong Yibo , Qian Fengsong , Chang Pengying , Fan Mengqi , Deng Jun , Xu Chen
Published: August 2022

The use of metal foil catalysts in chemical vapor deposition of graphene films makes graphene transfer an ineluctable part in graphene device fabrication, which greatly limits the industrialization. Here, an oxide phase-change material (V2O5) was found to have the same catalytic effect on graphene growth as conventional metals. A uniform large-area graphene film can be obtained on a 10 nm V2O5 film. Density functional theory was used to quantitatively analyze the catalytic effect of V2O5. Due to the high resistance property of V2O5 at room temperature, the obtained graphene can be directly used in devices with the V2O5 as an intercalation layer. A wafer-scale graphene-V2O5-Si Schottky photodetector array was successfully fabricated. Illuminated by a 792 nm laser, the responsivity of the photodetector can reach 266 mA/W at 0 V bias and 420 mA/W at 2 V. The transfer-free device fabrication process enables high feasibility in industrialization.
Streamlining urban forest monitoring based on a large-scale tree survey: A case study of highway vegetation in Hong Kong
Authors: Him Louis Lee Shing , Zhang Hao , Kwun Kathy Ng Tze , Lo Shun Cheong , Lun Alan Yu Siu
Published: August 2022

Urban tree monitoring is essential to successful urban forestry. Transport land use accommodates huge tree stock which require substantial monitoring efforts. In Hong Kong, more research is needed to take into considerations how monitoring works can be modified in response to variations in tree stand characteristics. This case study aimed to illustrate the usefulness of a large-scale tree survey in mainstreaming future tree monitoring and management in transport land use. 7,209 trees were found in a large-scale tree survey conducted in 53 slopes and 52 verges along San Tin Highway in Hong Kong. Dominance by Corymbia citriodora (72%) was observed, especially for the highway verges. Using chi-square tests, significant associations were found between monospecific stands, habitat type, and tree risk rating. A logistic regression model was constructed to predict the occurrence of monoculture. Every metre increase in maximum tree height, the odds of a stand being monospecific would be 1.22 times greater. Stands on verges had 5.26 times greater odds of being monospecific against slope. The associations and relationships were attributed to the dominance of C. citriodora. By boosting the logistic model, model reliability increased as kappa rose from 0.51 to 0.63, while balanced accuracy improved from 0.72 to 0.85. The occurrence of monospecific stands could be reliably predicted using maximum tree height and habitat type of tree stands. These quantitative findings monitoring can guide urban forest monitoring. Through a better understanding of urban forest structure and composition, future monitoring can aid the mainstreaming of urban forestry in transport planning.
Modeling and simulation of SWARA path loss model for underwater acoustic communication in multipath environment
Authors: More Sangram Sampatrao , Bartakke Prashant P. , Aggarwal Monika
Published: August 2022

The propagation loss varies with underwater channel conditions which might considered to be random phenomena. Modeling propagation loss will become meaningful iff mathematical model includes parameters namely viz projector's transmit voltage response (TVR), hydrophone's open circuit receiving response (OCRR), directivity patterns of both, channel parameters such as salinity, temperature, pressure, enclosure boundary conditions along with placements of Tx & Rx nodes & their operating frequency. To best of our knowledge, existing simulators are unable to trace eigen rays for very short range i.e. less than 0.1 km and therefore they are not suitable for computation of such short-range propagation losses. We have made an attempt to overcome limitations of existing simulators wherein we proposed mathematical model SWARA which includes parameters as mentioned above to study very short-range propagation losses using plane wave theory. To validate simulated propagation loss, we conducted tank trials at UWAA Lab, CARE, IIT Delhi to investigate effects of placements of projector & hydrophone on occurrence of transmission loss. The Simulated results of SWARA mathematical model shows that simulated maximum transmission loss is -0.18 to 0.10 times experimental maximum transmission loss, whereas simulated minimum transmission loss is -0.36 to 0.19 times experimental minimum transmission loss for placements of projector (ITC 1042) and hydrophone (Keltron 8240000001) at depths varying from 0.3m-1.2m & range varying from 2m-3.2m in uw tank facility of 3.85m long 2.4 wide 2m deep for 30kHz chirp signal (10kHz bandwidth) under static channel conditions.