bluuebunny/crossref_metadata_2025 huggingface dataset:
Subseasonal Forecast Skill of Snow Water Equivalent and Its Link with Temperature in Selected SubX Models
Authors: Diro G. T. , Lin H.
Published: December 2019

Accurate and skillful subseasonal forecasts have tremendous potential for sectors that are sensitive to hazardous weather and climate events. Analysis of prediction skill for snow water equivalent (SWE) and near-surface air temperature (T2m) is carried out for three (GEPS, GEFS, and FIM) global models from the subseasonal experiment (SubX) project for the 2000–14 period. The prediction skill of SWE is higher than the skill of T2m at week-3 and week-4 lead times in all models. The GEPS forecast tends to yield higher (lower) prediction skill of SWE (T2m) compared to the other two systems in terms of correlation skill score. The snow–temperature relationship in reanalysis is characterized by a strong negative correlation over most of the midlatitude regions and a weak positive correlation over high-latitude Arctic regions. All forecast systems reproduced well these observed features; however, the snow–temperature relationship is slightly weaker in the GEPS model. Despite the apparent lack of skill in temperature forecasts at week 4, all three models are able to predict the sign of temperature anomalies associated with extreme SWE conditions albeit with reduced intensity. The strength of the predicted temperature anomaly associated with extreme snow conditions is slightly weaker in the GEPS forecast compared to reanalysis and the other two models, despite having better skill in predicting SWE. These apparent disparities suggest that weak snow–temperature coupling strength in the model is one of the contributing factors for the lower temperature skill.
A grounded theory of local ownership as meta-conflict in Afghanistan
Authors: Collins Andrew EE , Thiessen Chuck
Published: December 2019

Internationally sponsored interventions in fragile and conflict-affected states are often resisted by domestic actors who have deep local knowledge, profoundly different expectations of political processes, and keen desires to shape their country’s future. Many forms of local resistance can damage or stall the progress of externally driven peacebuilding, but the critical peacebuilding literature has suffered from an inability to articulate coherent strategic alternatives to the dominant paradigm of liberal interventionism. This paradigm, we argue, is actually part of what fuels continued resistance: as external actors seek to implant liberal democratic norms into local bureaucratic and political cultures, countless sites of conflict emerge, with local and international actors jockeying between and amongst each other for position, resources, and control over the specificities of reform. These struggles – effectively a competition over local ownership – are at the centre of peacebuilding and will determine short- and long-term intervention outcomes. Focusing on the case of political reform in Afghanistan, this article develops a grounded theory of ownership as ‘meta-conflict’, in which participant voices from local and international peacebuilding leaders, working in-country, are given a primary role in determining the compatibility of the donor community’s prevailing liberal agenda with local requirements for building peace.
Cost-effectiveness of Argatroban Versus Heparin Anticoagulation in Adult Extracorporeal Membrane Oxygenation Patients
Authors: Cho Angelina E. , Jerguson Kathleen , Peterson Joy , Patel Deepa V. , Saberi Asif A.
Published: December 2019

Purpose: The purpose of this study was to evaluate the cost effectiveness of argatroban compared to heparin during extracorporeal membrane oxygenation (ECMO) therapy. Methods: This was a retrospective study of patients who received argatroban or heparin infusions with ECMO therapy at a community hospital between January 1, 2017 and June 30, 2018. Adult patients who received heparin or argatroban for at least 48 hours while on venovenous (VV) or venoarterial (VA) ECMO were included. Patients with temporary mechanical circulatory assist devices were excluded. Each continuous course of anticoagulant exposure that met the inclusion criteria was evaluated. The primary endpoint was the total cost of anticoagulant therapy for heparin versus argatroban, including all administered study drugs, blood or factor products, and associated laboratory tests. Secondary endpoints included safety and efficacy of anticoagulation with each agent during ECMO. Documentation of bleeding events, circuit clotting, and ischemic events were noted. Partial thromboplastin time (PTT) values were evaluated for time to therapeutic range and percentage of therapeutic PTTs. Results: A total of 11 courses of argatroban and 24 courses of heparin anticoagulation were included in the study. The average cost per course of argatroban was less than the average cost per course of heparin ($7,091.98 vs $15,323.49, respectively; P value = 0.15). Furthermore, argatroban was not associated with an increased incidence of bleeding, thrombotic, or ischemic events. Conclusion: Argatroban may be more cost-effective during ECMO therapy in patients with low antithrombin III levels without increased risk of adverse events.
Y-Site Compatibility of Intravenous Levetiracetam With Commonly Used Critical Care Medications
Authors: Lee Tyler M. , Villareal Carolyn L. , Meyer Lisa M.
Published: December 2019

Purpose: Levetiracetam is an antiepileptic medication commonly used in critical care areas for seizure treatment or prophylaxis. Compatibility data of levetiracetam with other critical care medications are limited, which can make administration challenging. This study aims to assess the physical Y-site compatibility of intravenous levetiracetam with some other commonly used critical care medications. Methods: Y-site administration was simulated by independently mixing levetiracetam with each of 11 selected medications in a 4-dram, colorless, screw-cap, glass vial, at a 1:1 ratio. Clinically used concentrations of each medication were compounded in 0.9% sodium chloride following United States Pharmacopeia chapter 797 standards. Physical compatibility was observed and assessed at 0, 15, and 30 minutes after mixing. Medication mixtures were considered physically incompatible if there was visual evidence of color change, gas evolution, haze, or particulate formation, pH change >10%, or if they had an absorbance value >0.010 A. Results: No evidence of physical incompatibility was observed during simulated Y-site testing with cisatracurium 1 mg/mL, dexmedetomidine 4 µg/mL, fosphenytoin 15 mg PE/mL, norepinephrine 16 mg/mL, norepinephrine 32 mg/mL, norepinephrine 64 mg/mL, piperacillin-tazobactam 33.75 mg/mL, propofol 10 mg/mL, vancomycin 5 mg/mL, or vasopressin 1 unit/mL when tested in 0.9% sodium chloride. Levetiracetam was incompatible with piperacillin-tazobactam 45 mg/mL. Conclusion: Levetiracetam 5 mg/mL in 0.9% sodium chloride was found to be physically compatible for 30 minutes with 10 of the 11 medications tested during simulated Y-site administration.
The effect of radiation exposure on carbon fiber-reinforced Rohacell® core laminate structural composites
Authors: Zaldivar Rafael J , Marques D , Barrie C , Patel D
Published: December 2019

Two equivalent density foams with identical shear strengths were used to manufacture carbon-fiber reinforced composite sandwich structures. One foam core system (Rohacell® 71 WF) has a cell diameter of 1117 µm and a wall thickness of 29 µm, while the second one (Rohacell® 71 HERO) has cell diameter of 146 µm and a wall thickness of 3 µm. A 60Co source was used to expose composites from 0 to 12 Mrads of radiation. Tests were used to evaluate the effect of radiation on the core shear strength and failure mechanism for both types of composites. The WF composites experienced a 75% decrease in core shear strength, while the HERO only exhibited an 8% decrease. The fracture behavior of the WF composites changed from a more compliant to a brittle fracture path with increased radiation. The fracture modes for the HERO were similar and did not change characteristics, even with maximum radiation dosage. Thermal analysis also showed that even after composite thermal processing, the WF foam retained a lower Tg in comparison to the HERO foam. Dynamic mechanical analyzer also indicated a faster rate of Tg degradation for the WF foam composites as a function of radiation, suggesting a lower degree of crosslinking which resulted in fragmentation of the network. Thermal gravimetric analysis and size exclusion chromatography also exhibited an earlier onset of thermal degradation for the WF foams with radiation. This investigation suggests that changes in composite mechanical properties with radiation are related to both foam macrostructure and the degree of crosslinking of the polymer foam. Careful evaluation must be performed to establish proper selection of the composite core material based on end of life environmental exposure.
Climate Shocks, Political Institutions, and Nomadic Invasions in Early Modern East Asia
Authors: Yin Weiwen
Published: December 2019

While a large literature argues negative climate shocks can trigger conflicts, recent findings suggest moderate climatic conditions lead to war. This article proposes a conditional theory by incorporating political institution as a moderating variable. I argue that, under the impact of negative climate shocks, centralized societies can mobilize more resources for war, compared to decentralized societies. Thus, the former is more likely to resort to well-organized plundering to address the scarcity problem caused by detrimental climate shocks. Besides, centralized societies have little incentive to plunder when the climatic conditions are moderate, as they can collect taxes regularly through centralized institutions. A comparison between the more centralized Manchurian and the less centralized Mongols on their conflictual behavior serves as an empirical test. I find that temperature was negatively associated with the probability of Manchurian invasion after they embraced centralization but had a positive effect on the likelihood of Mongol invasion.
Awareness of “The Real Cost” Campaign Among US Middle and High School Students: National Youth Tobacco Survey, 2017
Authors: Delahanty Janine , Ganz Ollie , Bernat Jennifer K. , Trigger Sarah , Smith Alexandria , Lavinghouze René , Rao Pamela
Published: December 2019

Objectives:

Monitoring awareness of a public education campaign can help to better understand the extent of sustained population-level exposure to the campaign. We examined unaided awareness (awareness that does not include a visual image to remind the respondent of the campaign or advertisement) and correlates of unaided awareness of “The Real Cost,” a national youth tobacco education campaign developed by the US Food and Drug Administration and implemented in 2014.

Methods:

This secondary analysis examined unaided campaign awareness by using data from the 2017 National Youth Tobacco Survey, a nationally representative school-based sample of young persons aged 9-19 years (n = 17 269) surveyed approximately 3 years after campaign launch. We compared unaided campaign awareness among various cigarette user groups (experimenters, susceptible nonsmokers, current or former smokers, and nonsusceptible nonsmokers). We examined associations between unaided campaign awareness and demographic and tobacco-related correlates, overall and by cigarette user group.

Results:

Three years after “The Real Cost” campaign was launched, most middle and high school students (58.5%) still reported unaided campaign awareness. Of 17 269 middle and high school students in the sample, 62.0% of susceptible nonsmokers and 64.5% of experimenters reported unaided campaign awareness. Among susceptible nonsmokers, unaided campaign awareness differed by age and race/ethnicity and was higher among students with greater tobacco-related harm perceptions (vs lower harm perceptions) and exposure to pro-tobacco marketing (vs no exposure).

Conclusions:

Future surveillance and research could examine awareness of “The Real Cost” campaign and effects of the campaign on young persons’ knowledge, attitudes, and beliefs to further assess the public health impact of tobacco prevention campaigns.
Effect of weave structure on the slicing cut resistance of woven fabrics
Authors: Messiry Magdi El , El-Tarfawy Shaimaa
Published: December 2019

Cutting processes using blades have found applications in many industries; for example, in garments, fiber–polymer composites, and high-performance fabric forming. In recent decades, the process of cutting the material using a robotic-controlled blade has raised concern about the value of the pressure and the cut force required for a certain type of woven fabric and the estimation of its value before the pressing and cutting process. A simple theoretical relation was established based on the fabric structure and yarn shear stress. The model formulation and experimental results to describe the basic theory of blade cutting fracture for woven fabric of different designs was derived. In this work, the experimental investigation of the effect of the fabric specifications, normal load, and the cutting speed on the cutting force was carried out, which indicates that the value of the specific cutting resistance of the fabric was found to be highly correlated with the fabric structure, warp and weft yarn count, Young’s modulus of the fabric, and fractional cover factors ratio ζ.
Grasping for Metaphors: Identity Ambiguity Contributes to the Preference for Metaphor Usage
Authors: Bultmann Michael N. , Wheeler Nathan , Jimenez Tyler , Arndt Jamie
Published: December 2019

Metaphors are frequently used linguistic devices that have the power to clarify ambiguous topics. In turn, a clear and stable self-concept is important to psychological functioning. The current article examines the potential role of self-concept clarity in understanding metaphor usage. Study 1 found that self-concept clarity negatively predicts metaphor usage. Study 2 found that experimentally lowering self-concept clarity led to more metaphor usage in general, and that self-reported self-concept clarity was implicated as a potential mediating factor. Implications are discussed.
The influence of media use on public perceptions of artificial intelligence in China: Evidence from an online survey
Authors: Cui Di , Wu Fang
Published: December 2019

With support from government and business, artificial intelligence is growing quickly in China. However, little is known of how media use shapes the Chinese public’s perception of artificial intelligence. Based on a national online survey (N = 738), this pilot study explored the linkages between media use and people’s risk perception, benefit perception, and policy support of artificial intelligence. Results showed that respondents perceive artificial intelligence as more beneficial than risky. Newspaper use was negatively associated with benefit perception and policy support, whereas television and WeChat use positively predicted both. Analyses of interaction effects showed that personal relevance could partly mitigate the influence of media use.
Preparation of high-strength SEBS nanocomposites reinforced with halloysite nanotube: Effect of SEBS-g-MA compatibilizer
Authors: Arman Nazlı , Tekay Emre , Şen Sinan
Published: December 2019

Poly(styrene -b-ethylene- co-butylene -b-styrene) (SEBS)/organophilic halloysite nanotube (Org-HNT) nanocomposites were prepared by solution mixing and then compression molded. Maleic anhydride grafted SEBS (SEBS- g-MA) was also used as a compatibilizer in preparation of SEBS/SEBS- g-MA/Org-HNT ternary nanocomposites. Surface morphologies and both static and dynamic mechanical analyses as well as thermal stabilities of the nanocomposites were carried out. Both the binary and ternary nanocomposites exhibited higher tensile moduli, tensile strength, and toughness values compared to neat SEBS. The elastic modulus was found to increase about 385% and 320% with addition of 3 and 5 phr Org-HNT into the SEBS matrix, respectively, while the maximum toughness was achieved via SEBS-5H composite with an increase of 45%. The ternary nanocomposite having 3 phr Org-HNT and 10 phr SEBS- g-MA (3H10SMA) gave about a 325% and 103% increase in the elastic modulus and toughness, respectively, together with a 75% increase in the tensile strength as the maximum value. This result was ascribed to interactions of the surface of the nanotubes with the maleic anhydride (MA) group of the compatibilizer. The same nanocomposite was also found to have two times higher dynamic storage modulus at 25°C than neat SEBS and almost the same damping value, which is an indication of improvement in the elastic character of SEBS without impairing its damping ability. Although a much higher damping value was obtained via use of 20 phr SEBS- g-MA with the same amount of nanotubes, the corresponding storage modulus decreased too much, close to that of neat SEBS. The enhanced tensile modulus, strength, and toughness of the 3H10SMA nanocomposite, which is consistent with its dynamic mechanical properties, indicate a good balance between the toughness/damping and stiffness. Moreover, all the nanocomposites exhibited better thermal stabilities than neat SEBS, showing higher midpoint degradation temperatures and peak maximum temperatures at which the maximum degradation occurs.
A review of pressure strain correlation modeling for Reynolds stress models
Authors: Panda JP
Published: December 2019

Most investigations of turbulent flows in academic studies and industrial applications use turbulence models. Out of the different turbulence modeling approaches Reynolds stress models have the highest potential to replicate complex turbulent flow phenomena at a reasonable computational expense. The Reynolds stress modeling framework is constituted by individual closures that approximate the effects of separate turbulence processes like dissipation, turbulent transport, pressure strain correlation, etc. Owing to its complexity and importance in flow evolution the modeling of the pressure strain correlation mechanism is considered the crucial challenge for the Reynolds stress modeling framework. In the present work, the modeling of the pressure strain correlation for homogeneous turbulent flows is reviewed. The importance of the pressure strain correlation and its effects on flow evolution via energy transfer are established. The fundamental challenges in pressure stain correlation modeling are analyzed and discussed. Starting from the governing equations we outline the theory behind models for both the slow and rapid pressure strain correlation. Established models for both these are introduced and their successes and shortcomings are illustrated using theoretical analysis, computational fluid dynamics simulations, and comparisons against experimental and numerical studies. Recent advances and developments in this field are presented and discussed. The application of machine learning algorithms such as Deep Neural Networks, Random Forests, and Gradient Boosted Regression Trees is summarized and examined. We report fundamental problems in the application of machine learning algorithms for pressure strain correlation modeling. Finally, challenges and hurdles for pressure strain correlation modeling are outlined and explained in detail to guide future investigations.
Effect of nozzle angle, turbine inlets and mass flow rate on the performance of a bladeless turbine
Authors: Ali Kamran Muhammad , Manzoor Shahryar
Published: December 2019

A comprehensive experimental study on the effects of different operating parameters on the efficiency of tesla turbine is reported. A bladeless turbine with nine discs and up to four turbine inlets was used, with water as the working fluid. The parameters investigated are the nozzle angle, number of turbine inlets and mass flow rates. Contrary to earlier studies, an effort was made to determine the performance under varying loading conditions, and hence identify the complete performance characteristics. The study revealed that efficiency of the turbine increases at lower nozzle angles and higher number of turbine inlets. It was observed that the nozzle angle becomes a significant parameter when the number of turbine inlets is increased. Efficiencies up to 78% were achieved when the working fluid entered the turbine through two nozzles at an angle of 7°. It was also noted that the turbine is most efficient at the designed mass flow rate, and the efficiency reduces appreciably if lower mass flow rates are fed to the turbine. The results obtained are an important contribution to the available knowledge and can be used as design references for further studies.
Polymer electrolyte membrane fuel cell flow field designs and approaches for performance enhancement
Authors: Çelik Erman , Karagöz İrfan
Published: December 2019

Polymer electrolyte membrane fuel cells are carbon-free electrochemical energy conversion devices that are appropriate for use as a power source on vehicles and mobile devices emerging with their high energy density, lightweight structure, quick startup and lower operating temperature capabilities. However, they need more developments in the aspects of reactant distribution, less pressure drops, precisely balanced water content and heat management to achieve more reliable and higher overall cell performance. Flow field development is one of the most important fields of study to increase cell performance since it has decisive effects on performance parameters, including bipolar plate, and thus fuel cell weight. In this study, recent developments on conventional flow field designs to eliminate their weaknesses and innovative design approaches and flow field architectures are obtained from patent databases, and both numerical and experimental scientific studies. Fundamental designs that create differences are introduced, and their effects on the performance are discussed with regard to origin, objective, innovation strategy of design besides their strength and probable open development ways. As a result, significant enhancements and design strategies on flow field designs in polymer electrolyte membrane fuel cells are summarized systematically to guide prospective flow field development studies.
Bovine cardiac mesothelial hyperplasia: a common incidental finding in adult cattle
Authors: Goldsmith Dayna A. , Adaska John M.
Published: December 2019

Cardiac mesothelial hyperplasia forming pale plaque lesions on the epicardial surface is a common incidental finding in the hearts of aged humans. A similar phenomenon with a more papillary appearance has also been reported as an incidental finding in dogs and mice. These lesions are believed to occur in response to friction between the epicardium and overlying pericardium. We investigated this lesion in adult cattle, a phenomenon that has been associated with bovine leukemia virus infection and epicardial lymphoma. We examined 73 hearts from adult cattle, predominantly of dairy breeds: 53 from a rendering facility and 20 from a state diagnostic laboratory. Cardiac mesothelial hyperplasia was much more prevalent in cattle than in other reported species (97% of examined hearts). The most common distribution was overlying the great vessels in a dark red papillary pattern. Cardiac mesothelial hyperplasia was also variably observed on all 4 cardiac chambers and the pericardium. Occasionally these lesions took on a smooth plaque-like appearance resembling those observed in humans. The lesions varied from 0.25 cm2 to covering 90% of the epicardial surface. No association was observed between cardiac mesothelial hyperplasia and bovine leukemia virus infection or cardiac lymphoma. Cardiac mesothelial hyperplasia was a common incidental finding in bovine hearts that must be distinguished from neoplasia and acute or chronic inflammation.
Resilience in Caregivers: A Systematic Review
Authors: Palacio G Carolina , Krikorian Alicia , Gómez-Romero María José , Limonero Joaquín T.
Published: December 2019

Background:

Resilience is a multidimensional construct that explains why people facing the consequences of adversity and stress can have a positive outcome, emphasizing adjustment to experiences that are perceived as threatening.

Objective:

The aim of this study is to review the construct of resilience and associated variables in caregivers of patients with chronic, advanced illness and at the end of life.

Methods:

The review included studies published between January 2009 and January 2019, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide reporting. The Medline, ScienceDirect, HINARI, PsychINFO, and SciELO databases were used for bibliographic exploration to identify research studies that examined the impact of resilience on adaptation and overall well-being in caregivers of patients with chronic and advanced illness.

Results:

A total of 23 quantitative and qualitative studies were identified whose aim was to describe the role of resilience in adaptation and coping in caregivers. In these studies, resilience was associated with a positive impact on the quality of life and emotional distress. Communication and social support increase resilient coping strategies. In most selected articles, the sampling strategy used was convenience sampling. Data collection used evaluation scales related to resilience and associated variables for quantitative studies, and semistructured interviews were used for qualitative studies.

Conclusion:

Promoting a resilient coping style in caregivers reduces the distress that normally results from illness-related changes in the biopsychosocial and spiritual dimensions. A resilient coping style can diminish the risk of stress and burden, and promote adaptation in the caregiver.
About a “New” Technique for Uvular Repair
Authors: Rossell-Perry Percy
Published: December 2019

This letter is about a recent publication in the Cleft Palate Craniofacial Journal titled: “The significance of uvula after palatoplasty: A new technique to improve the aesthetic outcome” published by Elsherbiny et al (Cleft Palate Craniofacial J 2018;55(3):451-455). The authors present the use of one hemi-uvula for uvular repair during primary palatoplasty as their “new technique.” The method of primary uvuloplasty using one-hemiuvula was extensively used by different surgeons in south America and presented and published in different scientific meetings and indexed scientific journals since the 90s. The original concept was described by Carlos Navarro in Perú and published by me in different scientific indexed journals and a textbook.
Negative-Pressure Wound Therapy in Foot and Ankle Surgery
Authors: Kunze Kyle N. , Hamid Kamran S. , Lee Simon , Halvorson Jason J. , Earhart Jeffrey S. , Bohl Daniel D.
Published: December 2019

Negative Pressure Wound Therapy (NPWT) is frequently utilized to manage complex wounds, however its mechanisms of healing remain poorly understood. Changes in growth factor expression, micro- and macro-deformation, blood flow, exudate removal, and bacterial concentration within the wound bed are thought to play a role. NPWT is gaining widespread usage in foot and ankle surgery, including the management of traumatic wounds; diabetic and neuropathic ulcers; wounds left open after debridement for infection or dehiscence; high-risk, closed incisions; tissue grafts and free flaps. This article reviews the rationale for NPWT, its proposed mechanisms of action, and the evidence regarding its clinical applications within the field of foot and ankle surgery.

Level of Evidence: Level V, expert opinion.
Arthroscopic tendon release for iliopsoas impingement after primary total hip arthroplasty: a retrospective, consecutive series
Authors: Tassinari Enrico , Castagnini Francesco , Mariotti Federica , Biondi Federico , Montalti Maurizio , Bordini Barbara , Traina Francesco
Published: December 2019

Introduction:

Aim of this study was to describe the clinical outcomes of 16 patients with iliopsoas (IP) impingement after primary total hip arthroplasty (THA), treated with an arthroscopic tendon release.

Methods:

16 patients (11 females/5 males), with a mean age of 57.8 ± 11.1 years (age at THA: 54.4 ± 11 years) and a diagnosis of IP impingement after primary THA, were treated with the Wettstein tenotomy. Preoperatively, every patient underwent a diagnostic ultrasonography guided peritendinous injection and a computed tomography (CT) scan. Every patient was clinically evaluated using WOMAC score. Subjective pain relief and active hip flexion strength were measured.

Results:

No complications related to arthroscopy were detected. Every cup was prominent with a mean axial overhang of 13 ± 4.8 mm (range 5–20 mm). At a mean follow-up of 27 ± 20.1 months (range 6–48 months), the WOMAC score was 83.7 ± 10.1 points. 13 patients out of 16 (81.3%) had a complete pain relief. 14 patients out of 16 (88%) regained full active hip flexion strength at the final follow-up. 1 patient was scheduled for cup revision after 6 months, due to persistent symptomatology. No demographic data or CT measurements about cup position statistically influenced the outcome.

Conclusions:

When preceded by an appropriate diagnosis, arthroscopic tenotomy proved safe and effective for IP impingement, regardless the magnitude of cup protrusion.
Party organizational change and leader effects on voting behavior: Linking the electoral and party faces of presidentialization
Authors: Ferreira da Silva Frederico
Published: December 2019

Changes in electoral markets in the late 20th century have forced political parties to adapt. Having lost much support and facing growing disaffection, parties often resorted to organizational structure reforms as means to reengage with a dealigned electorate. This article explores the impact of two changes in party organization—democratization of leadership selection procedures and increasing leadership power—on the extent to which leaders have an effect on voting behavior. In doing so, it analyzes the understudied interconnection between the electoral and the party faces of the presidentialization of politics thesis. The results provide mixed evidence regarding the relationship between both dimensions of presidentialization: more leadership power boosts leader effects, but only non-divisive direct leadership elections favor leader effects. This is a comparative study on Western democracies, combining individual-level data from the Comparative of Study of Electoral Systems with contextual data from the Political Party Database Project.
Complex families and health complaints among adolescents: A population-based cross-sectional study
Authors: Nilsen Sondre Aasen , Hysing Mari , Breivik Kyrre , Heradstveit Ove , Vingen Sunde Eilif , Stormark Kjell Morten , Bøe Tormod
Published: December 2019

Aims: The structure of adolescents’ families has become more complex over the last decades in several western countries. In parallel, health complaints among adolescents appear to have risen in the Nordic countries. This study aimed to examine the association between family structure and health complaints among Norwegian adolescents while capturing biological, half-, and stepsiblings (sibship-type) in the families. Methods: Data stem from the youth@hordaland study, an epidemiological study of adolescents aged 16–19 years ( N = 10,257; participation rate = 53%) conducted in 2012. This study is based on a subsample of 8808 adolescents who lived with parent(s). The adolescents provided detailed information on sociodemographics, family structure, sibship-type, and common health complaints among youth (headache, dizziness, and abdominal, neck, back, and shoulder pain). Results: Adolescents in nuclear families and joint physical custody (JPC) reported significantly lower levels of health complaints compared to peers in single- or stepparent families. Independent of family structure, biological siblings were associated with lower levels of health complaints, while stepsiblings were associated with higher levels of health complaints, but only among girls. These findings were robust to adjustments of sociodemographic variables. Conclusions: Health complaints are frequent but unequally distributed across family structures. Adolescents in nuclear families and JPC report lower levels of health complaints compared to peers in single- or stepparent families. Considering siblings appears to be relevant, as biological- and stepsiblings were related to adolescents’ symptoms, independent of family structure. In combination, knowledge about family structure and sibship-type may aid the identification of adolescents at risk of experiencing health complaints.
A Review of the First Long-term Implantable Continuous Glucose Monitoring System Available in the United States
Authors: Cowart Kevin
Published: December 2019

Background:

Although real-time continuous glucose monitoring (rtCGM) has been shown to improve glycemic control in patients with type 1 diabetes mellitus and type 2 diabetes mellitus treated with insulin, rates of adoption have been low. A novel approach, with the use of a long-term implantable continuous glucose monitoring (LTI CGM) has the potential to overcome barriers to rtCGM. The purpose of this review is to provide a background on the first LTI CGM technology to be approved, along with a review of contraindications, interference, safety, accuracy, and efficacy. Considerations for patient selection are discussed based on the available evidence.

Methods:

PubMed, EMBASE, and Cochrane Library were searched for keywords and subject headings to identify studies assessing LTI CGM.

Results:

Seven studies were identified which assessed LTI CGM. Mean absolute relative difference is similar to available CGM devices. Rates of adverse events were low. Change in hemoglobin A1c with LTI CGM may be comparable to rtCGM.

Conclusions:

Based on the available evidence, LTI CGM appears to be safe and accurate. Additional clinical trial investigation is warranted to evaluate the glycemic efficacy of LTI CGM.
Prevalence of ECG abnormalities and risk factors for QTc interval prolongation in hospitalized psychiatric patients
Authors: Ansermot Nicolas , Bochatay Meredith , Schläpfer Jürg , Gholam Mehdi , Gonthier Ariane , Conus Philippe , Eap Chin B
Published: December 2019

Background:

Psychiatric patients are at risk of cardiovascular diseases, and many psychotropic drugs can prolong QTc interval. Requirements for electrocardiogram (ECG) monitoring have been set up in our psychiatric university hospital. The objective of this study was to determine the proportion of adult patients who had an ECG during their hospitalization, the prevalence of ECG abnormalities, the evolution of the QTc after admission, and the risk factors for QTc prolongation.

Methods:

Retrospective analysis of ECGs and clinical data of all patients with a complete hospitalization in 2015. Assessment of the influence of covariates on QTc using linear mixed-effects models.

Results:

At least one ECG ( n = 600) was performed during 37.6% of the stays ( n = 1198) and in 45.5% of the patients ( n = 871). Among the patients with an ECG, 17.9% had significant ECG abnormalities, including 7.6% with a prolonged QTc. QTc measured at admission and during hospitalization did not change significantly ( n = 46, 419.4 ± 29.7 ms, 417.2 ± 27.6 ms, p = 0.71). In the multivariate model (292 patients, 357 ECGs), the covariates significantly associated with the QTc were gender (+15.9 ms if female, p < 0.0001), age (+0.4 ms/year, p = 0.0001), triglyceride levels (+5.7 ms/mmol/l, p = 0.005), and drugs with known risk of torsades de pointes (+6.2 ms if ⩾1 drug, p = 0.028).

Conclusions:

The prevalence of hospitalized psychiatric patients with an abnormal ECG indicates that ECGs should be performed systematically in this population. Prescription of psychotropic drugs should be done cautiously, particularly in patients with QTc prolongation risk factors.
Determinants of adherence to anti-hypertensive medications among adult hypertensive patients on follow-up in Hawassa Referral Hospital: A case–control study
Authors: Getenet Atsede , Tesfa Mulugeta , Ferede Aster , Molla Yalew
Published: December 2019

Introduction

Hypertension is a global challenge which accounts for high morbidity and mortality rates in the world. The availability of effective anti-hypertensive medications does not result in a good outcome in controlling blood pressure which points towards poor adherence. Thus, this study was conducted to assess the determinants of adherence to anti-hypertensive medication among hypertensive patients on follow-up in Hawassa Referral Hospital.

Methods

Institution-based case–control study was conducted on a sample of 289 clients from February to May 2018. Census was conducted on 1600 clients to select cases and controls. Then, systematic random sampling was used to select study subjects, and adherence was measured by Morisky medication adherence scale. The associations of variables were analyzed using bivariable followed by multivariable logistic regression analyses.

Results

The respondent’s adherence to medication was found to be 67% as measured by Morisky medication adherence scale. The multivariate logistic regression analysis showed that medication adherence was found to be better in younger age (<45) (AOR = 3.8), clients living in urban areas (AOR = 6.84), those clients who had good knowledge (AOR = 3.13), those with no co-morbidities (AOR = 3.14) and patients who controlled their blood pressure (<140/90) (AOR = 2.35).

Conclusions

The rate of medication adherence was found to be low, and hence educational interventions focusing on factors promoting adherence and patients’ health support should be implemented.
State Control and the Online Contestation of Iranian Female Spectators and Activists
Authors: Mohammadi Shahrzad
Published: December 2019

Drawing on feminist cultural studies, this article critically analyzes the interrelationship between state ideology and gender policies in the sporting domain with a particular focus on the prolonged interdiction of Iranian female spectators from stadiums. Data were collected from online social spaces such as Twitter, Facebook, and Instagram. The findings suggest that in the absence of free and democratic public spaces for negotiation of their rights, Iranian women have increasingly used social media and online campaigns as enabling platforms to partake in a communication discourse, raise awareness, practice democracy, mobilize masses, and protest against social injustice.
Clinical, radiographic, and survivorship analysis of a modular fluted tapered stem in revision hip arthroplasty
Authors: Picado Celso Hermínio Ferraz , Savarese Aniello , Cardamoni Vitor dos Santos , Sugo Arthur Tomotaka , Garcia Flávio Luís
Published: December 2019

Purpose:

Modular fluted tapered stems are one of the most commonly used implants in femoral revision surgery. Due to the relative lack of studies on the Restoration modular fluted tapered stem, we conducted a study to evaluate its short- to mid-term clinical, radiographic, and survival outcomes.

Methods:

We identified all 45 patients treated with this revision stem at our institution. Five patients did not complete the minimum 2-year follow-up, leaving 40 patients (41 hips) for assessment. Mean follow-up was 5.1 years (range 2–11 years). Clinical outcomes were assessed using the Harris hip score (HHS). Radiographs were evaluated for subsidence and loosening. Kaplan–Meier survival analysis was performed using revision of the stem for any reason as end point.

Results:

The mean HHS improved from 44.6 points preoperatively to 78.4 points at the most recent follow-up ( p < 0.0001). Nonprogressive subsidence occurred in 83% of the hips (mean 2.8 mm; range 1–7 mm). One stem (2.4%) showed progressive subsidence (20 mm) and was considered loose. The most common cause for reoperation was dislocation (three hips, 7.3%). The 10-year survivorship with revision of the stem for any reason as the end point was 93.5% (95% CI, 84.9–100%).

Conclusion:

There was a significant improvement in the HHS and a low likelihood of revision at short- to mid-term follow-up, adding to the current evidence base for use of this implant in revision surgery. A longer follow-up and a larger number of cases are necessary to fully evaluate its role and performance.
Safety assessment of Euglena gracilis ATCC 12894 whole cell biomass
Authors: Symonds Jennifer , Zhang Chonggang , Noble Adam , Kruger Claire
Published: December 2019

A safety assessment of the dried whole cell biomass of Euglena gracilis ATCC 12894 was performed by the bacterial reverse mutation (Ames) assay, an in vitro micronucleus assay, and a 90-day repeat oral toxicity study in Wistar rats. E. gracilis ATCC 12894 whole cell biomass has no added excipients and contains 33.8% protein, 28.8% β-glucans, 19.8% fat, 7.1% ash, and 2.8% moisture. The bacterial reverse mutation assay found no evidence of mutagenicity after exposure to E. gracilis ATCC 12894 whole cell biomass, with or without metabolic activity, at levels up to 1581 µg/plate, the limit dose for the assay. Similarly, no evidence of genotoxicity was observed in the micronucleus assay, with or without metabolic activation, up to 320 µg/mL, the limit dose for the assay. The subchronic toxicity study was performed with the following test article dose groups: 0 (control), 1250, 2500, and 5000 mg/kg/day, administered to male and female Wistar rats via oral gavage for 90 days. No test article-related mortalities or adverse events were reported during the study. Histopathological examination revealed some vacuolation in the livers of males in the 5000 mg/kg/day group. This finding was considered adaptive, due to the approximately 20% fat content of whole cell biomass, and was therefore test article-related, but not adverse. No such findings were reported in female rats in the study. The results of the subchronic toxicity study describe a no observed adverse effect level of at least 5000 mg/kg/day.
Urban planning in the post-zoning era: From hierarchy to self-organisation in the reform of the Finnish Land Use and Building Act
Authors: Rantanen Annuska , Rajaniemi Juho
Published: December 2019

Encountering cities as complex systems has been pictured as both an intellectual challenge and an urge to reconceptualise planning practices accordingly. Statutory planning in Finland, like in many other European countries, is built on the principles of hierarchical three-level zoning and area reservation codes. The zoning system reflects two historical tasks: the industrialising society’s need to separate uses and the post-war desire for hierarchical administrative structures. Both these demands are rapidly losing their importance. The article focuses on current urban planning practices and planning rules, discussing their limitations to cope with urban complexity and self-organised dynamics, and aiming to develop new rules that could potentially turn complexity into an asset. Evolving digital technologies provide completely new opportunities for developing urban planning into a more transparent and interactive tool. In this framework, we set out to study the development potentials of planning rules in Finland, where the drafting of a new Land Use and Building Act is currently underway calling for a reassessment of the operative role of the planning system.
Experimental investigation on tribological properties of UHMWPE with the addition of basalt fiber
Authors: Han Yi , Chen Jihong
Published: December 2019

To seek the effective and feasible way to enhance the tribological properties of ultrahigh-molecular-weight polyethylene (UHMWPE) materials, a comparative investigation on the tribological behavior of basalt fiber (BF) as filler in UHMWPE composites was carried out. BF/UHMWPE composites were investigated through friction and wear tests to evaluate its frictional and lubricate properties. The results showed that the friction coefficient of the UHMWPE composite decreased significantly under water sliding condition; under water and dry friction conditions, the friction coefficient decreases with the increase in load and rises as the rotational speed growing. When the BF/UHMWPE composites were tested under water-lubricated conditions, the material folding and pieces of debris were reduced obviously and the variation of wear depth was consistent with the results of friction coefficient. To evaluate the tribological properties of UHMWPE under various conditions, the research results make useful reference for UHMWPE manufacture and other relative experiments.
Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML
Authors: Masciarelli Silvia , Capuano Ernestina , Ottone Tiziana , Divona Mariadomenica , Lavorgna Serena , Liccardo Francesca , Śniegocka Martyna , Travaglini Serena , Noguera Nelida I. , Picardi Alessandra , Petrozza Vincenzo , Fatica Alessandro , Tamagnone Luca , Voso Maria Teresa , Lo Coco Francesco , Fazi Francesco
Published: December 2019

Key Points

RA synergizes with the N-glycosylation inhibitor tunicamycin and ATO to induce AML cell death via generation of ER and oxidative stress.
von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD
Authors: Atiq Ferdows , Schütte Lisette M. , Looijen Agnes E. M. , Boender Johan , Cnossen Marjon H. , Eikenboom Jeroen , de Maat Moniek P. M. , Kruip Marieke J. H. A. , Leebeek Frank W. G.
Published: December 2019

Key Points

VWF and FVIII levels after desmopressin, which mimic hemostatic response, are associated with the bleeding phenotype of type 1 VWD patients. Variability in VWF and FVIII response to hemostatic challenges may partly explain heterogeneity in bleeding phenotype of VWD patients.