bluuebunny/crossref_metadata_2025 huggingface dataset:
PARKING DEMAND ANALYSIS OF REST AND SERVICE AREA ALONG EXPRESSWAY IN SOUTHERN REGION, JOHOR MALAYSIA
Authors: Ramli Izzul , Hassan Sitti Asmah , Hainin Mohd. Rosli
Published: July 2024

Rest and Service Area (RSA) is an important aspect in highway operation in terms of safety and comfort for highway users. Stopping and resting at these facilities will help reducing users fatigue and thus avoiding possible accidents. Existing guidelines for RSA planning apparently provides insufficient information on the design capacity for estimating parking requirements for RSA. The objectives of this study were to determine the parking demand trend on RSA, and to evaluate significant parameters related to parking demand. This study was conducted on six RSA located in southern region of Peninsular Malaysia, Johor. Variations of traffic volume on major road and the size of the facilities on RSA were observed on two days for 10 hours for each site. Correlation analyses were conducted to determine the relationship of these two parameters as related to parking demand on RSA. It was found that the parking demand varies with time of the day and day of week. The analysis showed that there is a significant correlation between vehicular volume on major road and gross floor area to parking demand on RSA. Linear regression models were developed to predict parking demand on the RSA land use type. The developed models equations are recommended to be used for RSA land use type.
IDENTIFICATION OF PHARMACEUTICAL RESIDUES IN TREATED SEWAGE EFFLUENTS IN JOHOR, MALAYSIA
Authors: Yacob Halim , Ling Yong Ee , Hee-Young Kim , Oh Jeong-Eun , Noor Zainura Zainon , Mohd Din Mohd Fadhil , Mat Taib Shazwin , Ting Hun Lee
Published: July 2024

The introduction of pharmaceutical residues into aquatic environment has threatened the livelihood of aquatic organisms worldwide. The entrance of these residues into the environment originates from sewage effluents discharged from domestic wastewater treatment plants. Up to date, their presence in the sewage effluent is not monitored in Malaysia. Therefore, this study aims to identify the presence of pharmaceutical residues in the effluent domestic sewage treatment plants employed in Johor Bahru, Malaysia. Briefly, ten pharmaceutical compounds, including acetaminophen, sulfathiazole, sulfamethazine, sulfamethoxazole, clarithromycin, trimethoprim, lincomycin, carbamazepine, naproxen and ibuprofen, were selected based on their worldwide consumption. Sewage samples from five different types of sewage treatment system were collected. The samples were filtered prior to solid-phase extraction. Finally, the extracted samples were analysed with LC-MS/MS. The analyses showed that only sulfathiazole was not present in all effluent samples. Acetaminophen recorded the highest concentration of 9299 ng/L in an Imhoff Tank. Meanwhile, the lowest concentration of pharmaceutical residue detected was sulfamethazine, i.e. 0.843 ng/L, in a sequencing batch reactor. Overall, six out from ten pharmaceutical residues were found in all sewage samples denoting the inefficiency of current biological treatment systems in removing trace pharmaceutical compounds from sewage.
PATH CYCLABILITY ASSESSMENT INDEX MODEL USING DECISION TREE MAKING METHOD: A CASE OF DOHA-QATAR
Authors: Ferwati Mohammad Salim , Shafaghat Arezou , Keyvanfar Ali
Published: July 2024

Transportation is the major contributor of ever-increasing CO2 and Greenhouse Gas emissions in cities all around the world; while the number of vehicles is rapidly growing. Growing concern on reducing transportation hazardous emissions and securing energy sources has led to New Urbanism and Smart Growth policies declarations. The urban and transportation professionals are attempting to develop innovative techniques to change peopleâ€˜s travel mode selection to less energy-intensive modes, particularly, cycling. The current research has developed an urban index assessment model evaluates and analyzes cyclability of path segments in association with residentsâ€˜ decision making in cyclable route selection, called Path Cyclability Assessment Index (PACEX). The model was developed based on decision-tree-making (DTM) method to measure the qualitative data quantifiable. The model involves ninety (90) physical and environmental cyclability variables clustered into three layers of decision-tree-making (Layer 1: Features, Layer 2: Criteria, Layer 3: Sub-criteria). Although the model is applicable in any neighborhood, this research was implemented it in Doha, Qatar where specially needs for hosting FIFA 2022. The analysis result shows the sub-criterion F1.C1.S2 Existence of Crossing mostly affects to neighborhood cyclability (24.25%), in contrast, the sub-criterion F1.C3.S7 Street Surveillance affects least (4.82%); and overall neighborhood was ranked as grade B of cyclability ranking. The model supports both personal and society needs, preferences, and priorities of cyclable environment design and development. Using this model contributes to less energy consumption, less CO2 and GHG emissions, less street fatalities and accidents, simultaneously, promotes public health. Juxtaposing using the PACEX model aids decision makers and policy makers in sustainable urban development in prioritizing the allocation of resources for development and/or redevelopment of the area concerned.
LARGE DIAMETER PILE LOAD TEST WITH A CASE STUDY USING OSTERBERG - CELL
Authors: Bagui S. K. , Dinesh B. C. , Md. Kamal Khan , Sharif Shajib Ahsan Ahmad , Wahid Ruso Inthaqab
Published: July 2024

Static loading test using single level bidirectional â€“Cell was tested in March 2017 atPaira bridge in Bangladesh for initial load testing. Soil consists of soft silt with traced clay from0.0 m to 10.5 m underlain by various layer with very dense silty sand at the toe level and below.Pile was constructed reverse circulation method. Drilling slurry was composed of bentonite sluryfor 2.5 m diameter pile. The load cells were attached to a reinforcing cage at 18 m above toe.Static load test was 28days of casting the pile and tested. Testing was carried as per ASTM 1143with load increment 7.5 % estimated ultimate load. It was observed that downward movement ofreaching 220 mm and locked downward movement and O-Cell was given force for upwardmovement to find out skin fraction. Detailed analysis was carried out and it was found thatultimate load consisted of 49 MN skin frication and 30 MN end bearing sand safe design loadwas calculated as 33 MN.
MODELING SINGLE BARRETTES AS ELASTIC SUPPORT BY CCT
Authors: El Gendy Mahmoud , Ibrahim Hassan , El Arabi Ibrahim
Published: July 2024

Classical analyses of barrette foundation taking into account full interactions between barrette and the surrounding soil leads to a huge barrette stiffness matrix. Consequently, a large system of linear equations must be solved, especially for analyzing barrette group and barrette raft. To overcome this problem, a Composed Coefficient Technique (CCT) is developed for analyzing barrette. In the analysis, the elasticity of the barrette body is considered using the finite element method, while that of the soil elements is considered using flexibility coefficients. The compatibility between the vertical displacements of the barrette and the soil settlements at the soil-barrette interface is taken in the vertical direction only. This assumption is that the external load on the barrette head, which is expected to be heavy load, is applied in the vertical direction. For comparative examinations, the barrette elasticity is determined using either 1D or 3D finite elements. A series of examinations is carried out to verify the application for analyzing barrette by CCT. It was found that, treating the barrette as an elastic body and representing the barrette by either 1D or 3D finite elements, gives nearly the same results.
TRENDS AND SPATIAL VARIABILITY OF CLIMATE CHANGE IN NIGERIA’S COASTAL REGION
Authors: Agbonaye Augustine Iyekeoretin , Okonofua Ehizonomhen Solomon
Published: July 2024

A major challenge facing the Coastal Region of Nigeria is climate change and climate variability. An assessment of the trends and spatial variability of climate, critical for knowledge-based strategies needed for planning adequate mitigation and adaptation measures for the region, requires urgent attention. This study analysed spatial variability and temporary trends of climate change in the Nigeria Coastal Region .. Gridded monthly climatic data from the Climate Research Unit (CRU 0.5 x 0.5) for two climatic periods ((1956- 1986 and 1987-2016) were obtained. Tests for trend detection and magnitude determination utilized:  Mann-Kendal and Linear Regression—Thei-Sen Slope test. Climatic maps for rainfall and temperature from 1956 to 2016 for the coastal regions of Nigeria were developed by ordinary kriging. The results from statistical analyses suggest that there is very high rainfall variability with the coefficient of variability (CV) values ranging between 62.43% and 69.46 % and low-temperature variability with CV values ranging between 4.314% and 6.037%. The annual rainfall and temperature increased at the average rate of 3.047 mm yr-1. and 0.0126 oC yr-1 respectively. In 75% of the region, rainfall was decreasing, while in 25%, it was increasing. The implementation of adaptation and mitigation strategies should be mandatory due to the notable increase in temperature.
WAVE SPECTRUM ANALYSIS FOR OPERATIONAL OFFSHORE PLATFORM IN MALAYSIA WATER
Authors: Ahmad Saharuddin Syamil Aziem , Dzulkifli Nur Fatin Maisarah , Mukhlas Nurul ‘Azizah , Abu Husain Mohd Khairi , Mohd Zaki Noor Irza , Ahmad Shah Mohamad Shazwan , Umar Sarehati , Teng Ng Chiew , Syed Ahmad Sayyid Zainal Abidin
Published: July 2024

As an ageing platform has passed its design life of 20 to 30 years, it is crucial to identify wether it is still fit for operation based on the current environmental behaviour, particularly due to the wave impact.  Hence, an analytical approach of wave spectrum analysis between the wave behaviour and offshore structural response will be conducted. The aim is to verify the stability and safety of ageing offshore platforms with the current wave behaviour based on identifying wave characteristics, developing a normalized wave energy spectral density, and analyzing the natural frequency of offshore structural response. The methodology includes data collection from structural dynamic monitoring assessments, wave spectrum development using empirical models, and evaluation of offshore platform stability. The results will provide insights into platform stability, resonance risks, and safety assessment of ageing offshore platforms in Malaysian waters. The findings will contribute to recommendations for modifications or improvements to ensure the safety and integrity of offshore platforms in the specific region.
COMPUTERISED CALCULATIONS FOR WATER LEVEL AND VELOCITY VARIATIONS IN THE SURGE TANK SYSTEM
Authors: Demun Amat Sairin
Published: July 2024

Water level variations in the surge tank and velocity vanatlOn in the pressure conduits in a surge tank system can be computed by using the finite difference solution of the governing differential equations. A computer program that was written in Fortran 77 is based on the solution technique. A laboratory experiment in determining the variations of water level in a surge tank was conducted to complement the development of the computer program. The results of the calculated and recorded surge tank water level variation:>are compared and a goodness of a regression curve is expected.
ANALYSIS OF AN URBAN WATER SUPPLY BY LINEAR PROGRAMMING
Authors: Ismail Tarmizi
Published: July 2024

This study investigates the use of linear programming to determine waters distribution schedule from different sources to different water-demanding sectors as well as to determine the scheduled priority use of different types of water resources. For this purpose, the transportation and mixed integer programming algorithms are used. The formulation of both algorithms were analyzed using LINDO program. The method of linear programming (LP) is adopted to optimize water delivery schemes for Icbid City, the second largest city in Jordan. This city as well as the whole country depends mainly upon surface water, and groundwater resources which are scarce and expensive to exploit. The result of the study shows a reasonable argument where all surface water from all sources (Mukhaiba, Wadi Arab and Local supply) is used and none of the groundwater supply is diverted for agricultural purposes due to'its higher cost.
Développement Historique et Défis Actuels de la Responsabilité Sociale des Entreprise (Rse) Au Brésil
Authors: Pratlong Florent
Published: July 2024

Cet article examine le développement historique et les défis actuels de la responsabilité des entreprises au Brésil. Il propose une analyse approfondie de l'évolution des entreprises brésiliennes, qui sont passées d'activités philanthropiques ciblées à une perspective plus large incluant les impacts durables de leurs pratiques de gestion. Cette transition met en évidence l'importance croissante de la responsabilité sociale des entreprises (RSE) au Brésil, soutenue par les initiatives de fondations et d'instituts, malgré l'absence d'un cadre réglementaire strict. L'article souligne le caractère volontaire de la RSE parmi les entreprises brésiliennes, où les dirigeants adoptent des pratiques de gestion durable visant à promouvoir la qualité de vie et le développement en harmonie avec la conservation de l'environnement.
Checklist of oribatid mites (Acari: Oribatida) from China
Authors: Liu Dong , Chen Jun
Published: July 2024

The species checklist is the basic data that reflects the species diversity in a country or region. In order to commemorate the 100th anniversary of the taxonomic study of oribatid mites in China and the 60th anniversary of the Special Committee of Acarology of the Entomological Society of China, and to explore the China's biodiversity, and scientifically answer “how many species and what species are there in China”, we compiled a checklist of Chinese oribatid mites, including a total of 1000 species and 35 subspecies in 311 genera and 158 subgenera representing 112 families. In addition, we provided a brief history of taxonomic research on oribatid mites in China in the past 100 years, Chinese name, literature citations and provincial distribution information of each species and subspecies, and a list of species nomina nuda. This work will support China's actions to implement the “Convention on Biological Diversity”, and promote biodiversity research and protection.
A Comprehensive Planning Framework for Designing Effective Physical Activity Interventions in Youth
Authors: Saunders Ruth P. , Dowda Marsha , Dishman Rod K. , Pate Russell R.
Published: July 2024

Background: Effective physical activity (PA) interventions are needed to counter the insufficient and declining levels of PA in youth. These require an updated, comprehensive planning framework that consolidates recent decades of progress in promoting PA in young children, children, and adolescents. Effective PA interventions require program planning and conceptual model development that target a coordinated and multilevel set of age-specific PA determinants. Accordingly, this paper presents a comprehensive planning framework that researchers can use to design intervention research to promote PA in youth. Methods: The first author conducted targeted searches through Google Scholar to compile PA models/frameworks/guides applicable to youth, a comprehensive set of PA determinants, and determinant-linked strategies to promote PA focusing on review articles. The information was summarized in tables, synthesized, and used to create a planning framework, all of which were reviewed by coauthors. Results: The APPLE Framework for Planning PA Opportunities for Youth (APPLE = Age, PA focus, Place and time, Leverage relevant influences and strategies, and ensure Enjoyable PA opportunities) incorporated all core elements from targeted reviews to create a comprehensive planning framework. The APPLE Planning Framework has a set of questions/prompts that guide the intervention planning process and conceptual model templates to organize planning efforts for designing intervention research. Conclusions: The APPLE Framework for Planning PA Opportunities for Youth will enable researchers to develop comprehensive conceptual models to guide the design of PA interventions for youth. Future research should refine the model and its components to enable PA intervention research in youth to move forward.
How Transfer Behavior Impacts Consumer Perceptions and Intentions Toward College Athletes Who Pursue Name, Image, and/or Likeness Activities
Authors: Matthews Andrea L. , Pelkowski Jodi
Published: July 2024

Recent changes to the National Collegiate Athletic Association policy on name, image, and/or likeness and transfer policies have transformed how college athletes may market themselves as human brands. Above all, branding success depends on consumer perceptions. Using a national survey of U.S. consumers and an experiment, we test how transfer behavior impacts consumer purchase intentions for a collegiate athlete’s brand. We find that transferring to a National Collegiate Athletic Association Division I or Division II school decreases purchase intentions by lowering consumer identification with the athlete through perceived profit motive or perceived athlete quality, respectively. These findings contribute to branding theory and provide insight to players and schools, as they navigate the changing landscape of college athletics.
Exploring Sport Employees’ Conceptualizations of Meaningful Work
Authors: Baer Nathan R. , Zvosec Claire C. , Oja Brent D.
Published: July 2024

Modern sport management scholars have paired the fields of positive organizational behavior and human resource development with sport management to enhance the productivity of sport organizations through their employees. One area of study receiving increased attention is meaningful work, an emerging employee well-being metric whose definition is debated. The purpose of this study was to explore the ways in which sport employees conceptualize meaningful work. Semistructured interviews were conducted with 32 sport employees. The following themes were identified: meaningful work is work that serves, meaning gained from sport organizations, and individual meaningful work experiences. Discussion offers valuable implications for practitioners of sport management, as well as the emerging scholarly field of human resource development in sport management, and the evolving discourse surrounding meaningful work.
A Comparison of 2 Exercise Protocols in Athletes With Primary Subacromial Impingement Syndrome: A Randomized Clinical Trial
Authors: Ehsani Fatemeh , Taghizadeh Delkhoush Cyrus , Mirmohammadkhani Majid , Ehyaie Hanna
Published: July 2024

Context: To stabilize the humeral head within the glenoid fossa during arm elevation, the rotator cuff muscles may contribute through internal and external rotation. The main purpose of the current study was to compare the acromiohumeral distance between athletes with primary subacromial impingement syndrome who received progressive resistance exercises consisting of either shoulder internal or external rotation. Design: A randomized and controlled clinical study. Methods: Thirty athletes with primary subacromial impingement syndrome were enrolled and randomly divided into 2 experimental groups. The progressive resistance exercise protocol in experimental group I comprised shoulder internal rotation, while in experimental group II consisted of shoulder external rotation. The experimental groups worked out 3 days a week for 6 weeks. The experimental groups were compared with the control group consisting of 15 healthy athletes. The acromiohumeral distance was measured before and after the intervention using an ultrasound machine under the passive and active across no arm elevation and 45°of arm elevation. Results: The acromiohumeral distance significantly increased in both experimental groups under the passive and active arm positions following the intervention (P < .001), with no significant differences detected between the experimental groups (P > .665). The paired comparisons of the acromiohumeral distance discrepancy indicated a significant difference between the control group and each experimental group under the active and passive arm positions (P < .001), while no significant difference was observed between the experimental groups (P > .999). Conclusions: The present study revealed, for the first time, that both progressive resistance exercise protocols involving either the shoulder internal or the external rotation increased the acromiohumeral distance in individuals with primary subacromial impingement syndrome and improved associated pain and disabilities.
Nitrogen fixation in the widely distributed marine γ-proteobacterial diazotroph
Candidatus
Thalassolituus haligoni
Authors: Rose Sonja A. , Robicheau Brent M. , Tolman Jennifer , Fonseca-Batista Debany , Rowland Elden , Desai Dhwani , Ratten Jenni-Marie , Kantor Ella Joy H. , Comeau André M. , Langille Morgan G.I. , Jerlström-Hultqvist Jon , Devred Emmanuel , Sarthou Géraldine , Bertrand Erin M. , LaRoche Julie
Published: July 2024

The high diversity and global distribution of heterotrophic bacterial diazotrophs (HBDs) in the ocean has recently become apparent. However, understanding the role these largely uncultured microorganisms play in marine N
2
fixation poses a challenge due to their undefined growth requirements and the complex regulation of the nitrogenase enzyme. We isolated and characterized
Candidatus
Thalassolituus haligoni, a member of a widely distributed clade of HBD belonging to the Oceanospirillales. Analysis of its
nifH
gene via amplicon sequencing revealed the extensive distribution of
Cand.
T. haligoni across the Pacific, Atlantic, and Arctic Oceans. Pangenome analysis indicates that the isolate shares >99% identity with an uncultured metagenome-assembled genome called Arc-Gamma-03, recently recovered from the Arctic Ocean. Through combined genomic, proteomic, and physiological approaches, we confirmed that the isolate fixes N
2
gas. However, the mechanisms governing nitrogenase regulation in
Cand.
T. haligoni remain unclear. We propose
Cand.
T. haligoni as a globally distributed, cultured HBD model species within this understudied clade of Oceanospirillales.
Making sense of scattering: Seeing microstructure through shear waves
Authors: Annio Giacomo , Holm Sverre , Mangin Gabrielle , Penney Jake , Bacquët Raphael , Mustapha Rami , Darwish Omar , Wittgenstein Anna Sophie , Schregel Katharina , Vilgrain Valérie , Paradis Valérie , Sølna Knut , Nordsletten David Alexander , Sinkus Ralph
Published: July 2024

The physics of shear waves traveling through matter carries fundamental insights into its structure, for instance, quantifying stiffness for disease characterization. However, the origin of shear wave attenuation in tissue is currently not properly understood. Attenuation is caused by two phenomena: absorption due to energy dissipation and scattering on structures such as vessels fundamentally tied to the material’s microstructure. Here, we present a scattering theory in conjunction with magnetic resonance imaging, which enables the unraveling of a material’s innate constitutive and scattering characteristics. By overcoming a three-order-of-magnitude scale difference between wavelength and average intervessel distance, we provide noninvasively a macroscopic measure of vascular architecture. The validity of the theory is demonstrated through simulations, phantoms, in vivo mice, and human experiments and compared against histology as gold standard. Our approach expands the field of imaging by using the dispersion properties of shear waves as macroscopic observable proxies for deciphering the underlying ultrastructures.
Species-specific microsymbiont discrimination mediated by a
Medicago
receptor kinase
Authors: Yu Xiaocheng , Liu Jinge , Qin Qiulin , Zribi Ikram , Yu Jingyin , Yang Shengming , Dinkins Randy D. , Fei Zhangjun , Kereszt Attila , Zhu Hongyan
Published: July 2024

Host range specificity is a prominent feature of the legume-rhizobial symbiosis.
Sinorhizobium meliloti
and
Sinorhizobium medicae
are two closely related species that engage in root nodule symbiosis with legume plants of the
Medicago
genus, but certain
Medicago
species exhibit selectivity in their interactions with the two rhizobial species. We have identified a
Medicago
receptor–like kinase, which can discriminate between the two bacterial species, acting as a genetic barrier against infection by most
S. medicae
strains. Activation of this receptor-mediated nodulation restriction requires a bacterial gene that encodes a glycine-rich octapeptide repeat protein with distinct variants capable of distinguishing
S. medicae
from
S. meliloti
. This study sheds light on the coevolution of host plants and rhizobia, shaping symbiotic selectivity in their respective ecological niches.
Quantifying suicide contagion at population scale
Authors: Shaman Jeffrey , Kandula Sasikiran , Pei Sen , Galanti Marta , Olfson Mark , Gould Madelyn , Keyes Katherine
Published: July 2024

The spread of suicidal behavior among individuals is often described as a contagion; however, rigorous modeling of suicide as a dynamic, contagious process is minimal. Here, we develop and validate a model-inference system depicting suicide ideation and death and use it to quantify the contagion processes in the US associated with two prominent celebrity suicide events: Robin Williams during 2014 and Kate Spade and Anthony Bourdain, which occurred 3 days apart during 2018. We show that both events produced large transient increases of suicide contagion contact rates, i.e., the spread of suicidal thought and behavior, and a period of elevated suicidal ideation in the general population. Our modeling approach provides a framework for quantifying suicidal contagion and better understanding, preventing, and containing its spread.
Functional and epigenetic changes in monocytes from adults immunized with an AS01-adjuvanted vaccine
Authors: Bechtold Viviane , Smolen Kinga K. , Burny Wivine , de Angelis Simone P. , Delandre Simon , Essaghir Ahmed , Marchant Arnaud , Ndour Cheikh , Taton Martin , van der Most Robbert , Willems Fabienne , Didierlaurent Arnaud M.
Published: July 2024

The adjuvant AS01 plays a key role in the immunogenicity of several approved human vaccines with demonstrated high efficacy. Its adjuvant effect relies on activation of the innate immune system. However, specific effects of AS01-adjuvanted vaccines on innate cell function and epigenetic remodeling, as described for Bacille Calmette-Guérin (BCG) and influenza vaccines, are still unknown. We assessed the long-term functional and epigenetic changes in circulating monocytes and dendritic cells induced by a model vaccine containing hepatitis B surface antigen and AS01 in healthy adults (NCT01777295). The AS01-adjuvanted vaccine, but not an Alum-adjuvanted vaccine, increased the number of circulating monocytes and their expression of human leukocyte antigen (HLA)–DR, which correlated with the magnitude of the memory CD4
+
T cell response. Single-cell analyses revealed epigenetic alterations in monocyte and dendritic cell subsets, affecting accessibility of transcription factors involved in cell functions including activator protein-1 (
AP-1
),
GATA
,
C/EBP
, and interferon regulatory factor. The functional changes were characterized by a reduced proinflammatory response to Toll-like receptor activation and an improved response to interferon-γ, a cytokine critical for the adjuvant’s mode of action. Epigenetic changes were most evident shortly after the second vaccine dose in CD14
+
monocytes, for which accessibility differences of some transcription factors could persist for up to 6 months postvaccination. Together, we show that reprogramming of monocyte subsets occurs after vaccination with an AS01-adjuvanted vaccine, an effect that may contribute to the impact of vaccination beyond antigen-specific protection.
Supplemental Material: Double subduction controls on long-lived continental tectonics and subcontinental mantle temperatures
Authors: Li Lin-Sen , al. et
Published: July 2024

 Model parameters and methods, Figures S1–S7, Tables S1–S2, and Movies S1–S2.  
Recurrent haemorrhagic venous infarct in a patient with sickle cell disease
Authors: Al Ali Alyaa , Taji Sulaima Mhd , Al Zeyoudi Fatmah , Ramsi Musaab
Published: July 2024

Cerebrovascular accidents are uncommon but devastating complications of sickle cell disease (SCD). Notably, cerebral sinovenous thrombosis is rarely reported in SCD and poses a therapeutic dilemma regarding anticoagulation. Herein, we describe a challenging case of a patient with sickle thalassaemia admitted to the hospital with recurrent haemorrhagic infarct secondary to cerebral sinus thrombosis. The patient was successfully treated with anticoagulation without neurological deficit. No embolic or other thrombotic aetiology was found, and the stroke was presumed due to sickle cell disease, leading to a hypercoagulable state. Our case report highlights the value of early recognition of this rare but potentially life-threatening condition in SCD, considers other options of anticoagulation therapy and emphasises the importance of close multidisciplinary follow-up particularly post hospital discharge.
Management of pediatric pial arteriovenous fistulas with a single connection: two illustrative cases
Authors: Costa Matias Luis , Dennis Bryce Garrison , Chen Karen , Kan Peter
Published: July 2024

Pediatric arteriovenous fistulas (PAVFs) are rare, representing only 7.3–17.2% of all pediatric shunts.1 2 In a number of cases they can lead to life-threatening venous hypertension, hydrocephalus and macrocrania,3 heart failure,1 hemorrhagic stroke,4 5 seizures,3 and cognitive developmental issues.1–3 In selected circumstances, early and aggressive treatment is recommended.

We present two cases of single-connection, high-flow PAVFs. Case 1 represents a mid-basilar PAVF treated through a transarterial approach, while case 2 represents a quadrigeminal cistern PAVF treated with several transarterial sessions followed by a final transvenous session. The procedures are shown in video 1.

Video 1

 Clinical cases demonstrating endovascular treatment of pediatric pial arteriovenous fistulas.
On constituent links of genus two handlebody-knots
Authors: Okazaki Shin’ya
Published: July 2024

A genus two handlebody-knot is a genus two handlebody embedded in the three-sphere. In this paper, we describe some necessary conditions for a two-component link to be a constituent link of a genus two handlebody-knot. We give a lower bound of the crossing number of constituent links of a genus two handlebody-knot such that two-variable Alexander polynomial of the link is nonzero.
h-Extra r-Component Connectivity of 3-Ary n-Cubes
Authors: Jagadale Uday , Shinde Amruta , Malavadkar Prashant
Published: July 2024

For a vertex subset [Formula: see text] of a connected graph [Formula: see text] the [Formula: see text]-extra [Formula: see text]-component connectivity of [Formula: see text] is the minimum cardinality of [Formula: see text] such that [Formula: see text] is disconnected with [Formula: see text]-components and each component contains more than [Formula: see text] vertices. It is denoted by [Formula: see text] In this paper, we investigate the [Formula: see text]-extra 3-component connectivity of [Formula: see text]-ary [Formula: see text]-cube [Formula: see text] for [Formula: see text] For [Formula: see text] [Formula: see text] and [Formula: see text]
3D Face Reconstruction Based on ResNet Feature Extraction and CBAM
Authors: Yan Tianxing , Zhao Yuhang , Xue Zhichao , Yilihamu Yaermaimaiti
Published: July 2024

In view of the scarcity, high cost and lack of diversity of three-dimensional (3D) face datasets, this paper designs an end-to-end self-supervised learning 3D face reconstruction network, which uses single 2D face image as input. The model bypasses the 3D face datasets and only uses the 2D face datasets for training to achieve high-precision 3D face reconstruction without any 3D face prior. First, the improved ResNet50 feature extraction module is introduced to extract and characterize the input image by deep convolutional network. Then, a lightweight convolutional block attention module is added to the face prediction subnetwork. On the one hand, channel attention extracts different information included in the image, and on the other hand spatial attention finds the location of the information. So, the serialized attention operation could accurately find the features required for different parameter predictions, further improving face reconstruction parameters’ prediction accuracy. Finally, training, ablation and comparison experiments were conducted on CelebFaces Attributes, basel face model and Photoface datasets, and the combined loss function of pixel loss and perception loss was selected. The pixel loss function was calculated at the pixel microscopic level, and the perception loss function was calculated at the image macroscopic convolution level. The combination of the two could complement each other. Compared with the historical optimal results of the same network structure, the scale-invariant depth error and mean angle deviation of the proposed algorithm are improved by 5.2% and 8.2%, respectively. Experimental results strongly prove the effectiveness of the algorithm.
Linear codes locating m-repeated solid burst errors
Authors: Kumar Subodh , Sinha Uttam Kumar , Lata Tarun
Published: July 2024

This study provides necessary condition (lower bound) and sufficient condition (upper bound) for the existence of Solid Burst (SB) errors locating PCD’s codes within a sub-block where the length of the code is assumed that it is split up into a fix number of identically sized sub-blocks. An example of such a code is also provided. The codes obtained here have been compared with the previously existing codes that are capable to detect and locate the repeated burst errors.
Chemostratigraphic characterization of the Lower Paleozoic Amdeh Formation outcrops and correlation to the subsurface Haima Supergroup and Nimr Group, Sultanate of Oman
Authors: Moss Jamie , Tansell Clare , Gómez-Pérez Irene , McCabe Ross , Fairey Brenton , al Thohli Badar
Published: July 2024

A chemostratigraphic correlation between the siliciclastic Lower Paleozoic Amdeh Formation outcrops of the Saih Hatat area, just south of Muscat, and the hydrocarbon-bearing Haima Supergroup and Nimr Group of subsurface Oman is presented. The Amdeh Formation is a 3.4 km-thick succession of Cambrian to Ordovician-aged sandstones and shales, divided into five lithological members (Am1–Am5). The Amdeh Formation type section was sampled throughout for inorganic elemental geochemistry, quantitative mineralogy and U–Pb zircon geochronology.

A robust chemostratigraphic framework for the equivalent Haima Supergroup and Nimr Group intervals, defined in the subsurface, is utilized to correlate with the Amdeh Formation. The Amdeh is interpreted to be a basinward, fully marine, time equivalent of the subsurface Haradh (and likely also the Karim), Amin, Miqrat, Al Bashair, Barik, Mabrouk, Barakat, Ghudun and Saih Nihayda formations. This correlation is based on the identification of key mineralogical, depositional, provenance and sequence stratigraphic events within the inorganic geochemical data, guided by outcrop observations of depositional facies and key surfaces, and existing biostratigraphy.

Positioned beyond the northern edge of the Ghaba Salt Basin, the Amdeh Formation outcrops provide important constraints on subsurface reservoir distribution, palaeogeography and basin evolution, factors that are relevant to deep gas prospectivity.
Triangle Centrality
Authors: Burkhardt Paul
Published: July 2024

Triangle centrality is introduced for finding important vertices in a graph based on the concentration of triangles surrounding each vertex. It has the distinct feature of allowing a vertex to be central if it is in many triangles or none at all.

Given a simple, undirected graph

\(G=(V,E)\)

with

\(n=|V|\)

vertices and

\(m=|E|\)

edges, let

\(\triangle(v)\)

and

\(\triangle(G)\)

denote the respective triangle counts of

\(v\)

and

\(G\)

. Let

\(N(v)\)

be the neighborhood set of

\(v\)

. Respectively,

\(N_{\triangle}(v)\)

and

\(N_{\triangle}[v]=\{v\}\cup N_{\triangle}(v)\)

denote the set of neighbors that are in triangles with

\(v\)

and the closed set including

\(v\)

. Then the triangle centrality for a vertex

\(v\)

is

\(\begin{align*}TC(v)=\frac{\frac{1}{3}\sum_{u\in N_{\triangle}[v]}\triangle(u)+\sum_{w\in\{N(v)\setminus N_{\triangle}(v)\}}\triangle(w)}{\triangle(G)}.\end{align*}\)

We show experimentally that triangle centrality is broadly applicable to many different types of networks. Our empirical results demonstrate that 30% of the time triangle centrality identified central vertices that differed with those found by five well-known centrality measures, which suggests novelty without being overly specialized. It is also asymptotically faster to compute on sparse graphs than all but the most trivial of these other measures.

We introduce optimal algorithms that compute triangle centrality in

\(O(m\overline{\delta})\)

time and

\(O(m+n)\)

space, where

\(\overline{\delta}\leq O(\sqrt{m})\)

is the
average degeneracy
introduced by Burkhardt, Faber, and Harris (2020). In practical applications,

\(\overline{\delta}\)

is much smaller than

\(\sqrt{m}\)

so triangle centrality can be computed in nearly linear time. On a Concurrent Read Exclusive Write (CREW) Parallel Random Access Machine (PRAM), we give a near work-optimal parallel algorithm that takes

\(O(\log n)\)

time using

\(O(m\sqrt{m})\)

CREW PRAM processors. In MapReduce, we show it takes four rounds using

\(O(m\sqrt{m})\)

communication bits and is therefore optimal. We also derive a linear algebraic formulation of triangle centrality which can be computed in

\(O(m\overline{\delta})\)

time on sparse graphs.
Energy‐Efficient Routing Algorithm for Optimizing Network Performance in Underwater Data Transmission Using Gray Wolf Optimization Algorithm
Authors: Khan Gulista , Mishra Prashant Kumar , Agarwal Ambuj Kumar , Alroobaea Roobaea , Asenso Evans , Kolla Bhanu Prakash , Sengan Sudhakar
Published: July 2024

Due to the aquatic nature of communication in the underwater world, the underwater acoustic sensor network (UASN) is commonly used. However, it has inherent limitations, such as limited bandwidth, high transmission energy, long propagation delays, void regions, and expensive battery replacement. Improving network lifetime (NL) is the primary objective since replacing batteries in UWSN is very expensive and challenging. NL is improved by having a high packet delivery ratio (PDR), reduced dead nodes, and reduced energy consumption (EC). If two more node batteries are depleted, they become dead nodes, causing partitions on the network and resulting in a void region problem. Void regions occur when a node has no forwarder node to forward data packets toward the sink node. Void nodes affect the routing techniques’ overall performance regarding end‐to‐end delay (EED), data loss, and EC. So, the primary objective of this work is to avoid void regions. For the same, this paper proposes a void hole detection algorithm. The algorithm selects the best next hop node based on the fitness function calculated by the gray wolf optimization (GWO) algorithm, considering only the vertical directions despite horizontal directions, further reducing the EED. The proposed approach is simulated using MATLAB, and the evaluation is based on data broadcast copies, PDR, EC, dead node number (DNN), average operational time (AOT), NL, and EED. The paper has presented a comparison with weighting depth and forwarding area division depth‐based routing (WDFAD‐DBR) routing protocol for underwater acoustic sensor network (UASN) and energy and depth variance‐based opportunistic void avoidance scheme (EDOVS) for UASN. WDFAD‐DBR avoids void holes by selecting forwarding nodes and taking the weighting sum of depth differences of two hops; in comparison, EDOVS considers not only the depth parameters but also the normalized residual energy. The proposed paper contributes to developing an energy‐efficient routing algorithm that removes void nodes by selecting the appropriate forwarder node in void regions based on the GWO algorithm. The proposed work increases the network lifetime by avoiding void regions and balancing the EC. The simulation results show that the proposed algorithm gains more than 20% PDR, less EC, and 60% less broadcasted copies of data packets and has more NL than the WDFAD‐DBR, and 10% improved PDR and lesser broadcasted copies were sent than EDOVS along with the enhanced NL, by varying the transmission range the proposed algorithm showing the better performance in terms of EC, PDR, and DNN along with the values of 61.6, 0.97, and 35 (scenario node 60 and transmission range 600 m) and 64.1, 0.89, and 25, respectively, by variable network size.
Analysis of Aeromagnetic Data for Enhancing Geologic Features Using Filtering Techniques Over the Congo Craton–Pan‐African Belt Contact, Centre‐East Cameroon
Authors: Mono Jean Aimé , Bouba Apollinaire , Amougou Olivier Ulrich Igor Owono , Ngoh Jean Daniel , Nyam Françoise Martine Enyegue A. , Mbarga Théophile Ndougsa
Published: July 2024

The Pan‐African mobile zone, situated at the margin of the Congo Craton in Cameroon, is characterized by a geological setting with polyphased tectonics, which can be summarised as the alternation of compression and extension events. The present study, conducted in a portion of the aforementioned zone, is aimed at investigating crustal structures using aeromagnetic data. To achieve this, a variety of advanced analysis and interpretation techniques were applied to reduce aeromagnetic data at the equator, including total horizontal derivative (THD), Centre for Exploration Targeting (CET), 3D Euler deconvolution (ED), spectral analysis, and 2D3/4 modeling. The results indicate that the study area can be divided into four magnetic units based on the magnetic properties (magnetic susceptibility, geometry, and depth) of the underlying rocks. The THD method reveals the presence of pseudocircular and linear structures, which are associated with mafic intrusions and faults, respectively. The structural trends of the lineament generated semiautomatically using the CET method suggest that the structures are oriented in order of priority: E‐W, WNW‐ESE, ENE‐WSW, and NE‐SW. These directions are probably related to the Pan‐African orogeny. According to the ED, the depths of these lineaments extend beyond 1250 m. A spectral analysis conducted on a profile intersecting some of the significant anomalies on the reduction to the equator (RTE) map indicates that the average depths of superficial and deep magnetic sources along this profile are approximately 0.5 and 6.5 km, respectively. The geological model obtained along this profile by direct 2D3/4 modeling indicates the presence of an ancient granitic basement, which is overlain by younger formations belonging to the Pan‐African.
Comparison of Genetic Diversity between Hatchery‐Reared and Wild Rock Bream (Oplegnathus fasciatus) Based on Microsatellite Markers and Mitochondrial COI Sequences
Authors: Liu Simiao , Yu Qin , Chen Ruiyi , Hu Weihua , Yan Xiaojun , Han Qingxi , Xu Dongdong , Zhu Qihui
Published: July 2024

Hatchery release of rock bream (Oplegnathus fasciatus) is common in the Zhoushan Sea region of the East China Sea as an efficient method for stock enhancement. Clarifying the genetic effects of farm‐raised populations on wild ones is important for understanding the health of fish stocks. Thus, this study collected six rock bream stocks (two wild, three hatchery‐reared, and one parental) for genetic diversity analysis using microsatellite markers and mitochondrial sequences. Although the results of mitochondrial sequence analysis showed that 61.26% of the genetic diversity resided among groups, indicating a high degree of genetic differentiation among wild, hatchery‐reared, and parental groups, the results of microsatellite analysis showed that 30% of the genetic diversity resided within the populations, indicating no obvious genetic differentiation among different groups. Our study suggests that though releasing hatchery‐reared rock bream for stock enhancement may not noticeably decrease the genetic diversity of wild populations in the Zhoushan Sea in the short term, long‐term genetic evaluations shall be taken to monitor genetic diversity in wild rock bream and ensure that the populations remain healthy.
Data from Phase I/Ib Clinical Trial of Sabatolimab, an Anti–TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti–PD-1 Antibody, in Advanced Solid Tumors
Authors: Curigliano Giuseppe , Gelderblom Hans , Mach Nicolas , Doi Toshihiko , Tai David , Forde Patrick M. , Sarantopoulos John , Bedard Philippe L. , Lin Chia-Chi , Hodi F. Stephen , Wilgenhof Sofie , Santoro Armando , Sabatos-Peyton Catherine A. , Longmire Tyler A. , Xyrafas Alexandros , Sun Haiying , Gutzwiller Sabine , Manenti Luigi , Naing Aung
Published: July 2024

AbstractPurpose:
Sabatolimab (MBG453) and spartalizumab are mAbs that bind T-cell immunoglobulin domain and mucin domain-3 (TIM-3) and programmed death-1 (PD-1), respectively. This phase I/II study evaluated the safety and efficacy of sabatolimab, with or without spartalizumab, in patients with advanced solid tumors.
Patients and Methods:
Primary objectives of the phase I/Ib part were to characterize the safety and estimate recommended phase II dose (RP2D) for future studies. Dose escalation was guided by a Bayesian (hierarchical) logistic regression model. Sabatolimab was administered intravenously, 20 to 1,200 mg, every 2 or 4 weeks (Q2W or Q4W). Spartalizumab was administered intravenously, 80 to 400 mg, Q2W or Q4W.
Results:
Enrolled patients (n = 219) had a range of cancers, most commonly ovarian (17%) and colorectal cancer (7%); patients received sabatolimab (n = 133) or sabatolimab plus spartalizumab (n = 86). The MTD was not reached. The most common adverse event suspected to be treatment-related was fatigue (9%, sabatolimab; 15%, combination). No responses were seen with sabatolimab. Five patients receiving combination treatment had partial responses (6%; lasting 12–27 months) in colorectal cancer (n = 2), non–small cell lung cancer (NSCLC), malignant perianal melanoma, and SCLC. Of the five, two patients had elevated expression of immune markers in baseline biopsies; another three had >10% TIM-3–positive staining, including one patient with NSCLC who received prior PD-1 therapy.
Conclusions:
Sabatolimab plus spartalizumab was well tolerated and showed preliminary signs of antitumor activity. The RP2D for sabatolimab was selected as 800 mg Q4W (alternatively Q3W or Q2W schedules, based on modeling), with or without 400 mg spartalizumab Q4W.
Supplementary Table S1 from CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
Authors: Pal Sumanta K. , Tran Ben , Haanen John B.A.G. , Hurwitz Michael E. , Sacher Adrian , Tannir Nizar M. , Budde Lihua E. , Harrison Simon J. , Klobuch Sebastian , Patel Sagar S. , Meza Luis , Dequeant Mary-Lee , Ma Anna , He Qiuling Ally , Williams Leah M. , Keegan Alissa , Gurary Ellen B. , Dar Henia , Karnik Sushant , Guo Changan , Heath Heidi , Yuen Rachel R. , Morrow Phuong K. , Agarwal Neeraj , Srour Samer A.
Published: July 2024

Summary of Treatment-Related TEAEs in Safety Analysis Set by Dose Level
Supplementary Figure S3 from CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
Authors: Pal Sumanta K. , Tran Ben , Haanen John B.A.G. , Hurwitz Michael E. , Sacher Adrian , Tannir Nizar M. , Budde Lihua E. , Harrison Simon J. , Klobuch Sebastian , Patel Sagar S. , Meza Luis , Dequeant Mary-Lee , Ma Anna , He Qiuling Ally , Williams Leah M. , Keegan Alissa , Gurary Ellen B. , Dar Henia , Karnik Sushant , Guo Changan , Heath Heidi , Yuen Rachel R. , Morrow Phuong K. , Agarwal Neeraj , Srour Samer A.
Published: July 2024

CTX130 construct