bluuebunny/crossref_metadata_2025 huggingface dataset:
Efek Mutasi K-RAS pada Kanker Kolorektal terhadap Terapi Antibodi Monoklonal anti EGFR
Authors: Nagara Farid Sastra , Utomo Ahmad R. , Sandra Ferry
Published: June 2022

Kanker kolorektal merupakan salah satu jenis kanker yang banyak diderita oleh masyarakat dan dapat disembuhkan jika terdeteksi dini. Salah satu penyebab kanker adalah terjadinya mutasi pada gen-gen tertentu. Mutasi pada gen K-RAS sering ditemui pada tahap awal kanker kolorektal. Cetuximab dan Panitumumab merupakan contoh antibodi monoklonal yang telah digunakan dalam penanganan kanker kolorektal. Dari penelitian-penelitian yang telah dilakukan, penanganan pasien kanker kolorektal menggunakan Cetuximab dan Panitumumab menunjukkan respon yang positif terhadap pasien yang tidak memiliki mutasi pada gen K-RAS. Pemberian Cetuximab atau Panitumumab pada pasien yang memiliki mutasi pada gen K-RAS memiliki kemungkinan kecil untuk mendapatkan manfaat klinis sehingga hal ini dapat menjadi pertimbangan dalam pemberian obat kepada pasien.Kata kunci: KRAS, kanker kolorektal, antibodi anti EGFR
Validitas Diagnostik Fine Needle Aspiration Biopsy Kelenjar Getah Bening Inguinal yang Teraba pada Karsinoma Penis di RSUP Sanglah, Denpasar
Authors: - Suarsana , - Sastrodihardjo , Oka Gde
Published: June 2022

Penelitian ini bertujuan untuk mengetahui validitas diagnostik dari pemeriksaan fine-needle aspiration biopsy (FNAB) dalam mendeteksi metastasis karsinoma penis pada kelenjar getah bening inguinal yang teraba. Untuk itu, semua penderita yang bersedia dan secara klinis didiagnosis sebagai karsinoma penis disertai kelenjar getah bening inguinal yang teraba dilakukan tindakan FNAB serta biopsi pada kelenjar getah bening inguinal. Selanjutnya, spesimen biopsi diperiksa secara histopatologi. Kemudian dilakukan uji diagnostik terhadap 36 penderita karsinoma penis dengan stage I (0), stage II (13), stage III (19), dan stage IV (4). Hasil FNAB pada kelenjar getah bening yang teraba memiliki sensitivitas sebesar 92,31%; spesifisitas 86,36%; positive likelihood ratio 6,77; dan negative likelihood ratio sebesar 0,09. Kesimpulannya, FNAB adalah sebuah modalitas diagnostik yang valid dan akurat dalam mendeteksi metastasis karsinoma penis pada kelenjar getah bening inguinal yang teraba. Karena modalitas ini sederhana, mudah, cepat, dan murah maka FNAB dapat digunakan sebagai uji diagnostik rutin dalam mendeteksi adanya metastasis karsinoma penis pada kelenjar getah bening inguinal yang teraba.Kata kunci: FNAB, karsinoma penis, kelenjar getah bening inguinal yang teraba, sensitivitas, spesifisitas, positive likelihood ratio, negative likelihood ratio.
Penanganan Kanker Prostat Stadium II pada Penderita Berusia 70 Tahun atau Lebih: Pengalaman Dua Rumah Sakit Tersier di Jakarta
Authors: Umbas Rainy
Published: June 2022

Saat ini, terdapat beberapa cara pengobatan kanker prostat dan usia penderita merupakan salah satu faktor untuk menentukan pilihan pengobatan selain derajat dan stadium penyakit. Tujuan penelitian ini adalah untuk mengetahui cara dan hasil pengobatan penderita kanker prostat stadium II yang berusia 70 tahun atau lebih di rumah sakit Cipto Mangunkusumo dan rumah sakit kanker Dharmais, Jakarta. Selama periode Januari 1995 sampai dengan Desember 2007, terdapat 74 penderita kanker prostat sesuai tujuan penelitian ini di kedua rumah sakit tersebut. Terdapat 40,5% penderita yang mendapat radioterapi dengan rerata survival 54,3 bulan dan 47,3% menerima pengobatan hormonal dengan rerata survival 55,2 bulan. Sekitar 60% pengobatan hormonal dilakukan dengan pemberian suntikan GnRH agonis. Angka survival 5 tahun penderita yang mendapat radioterapi lebih besar dibanding penderita yang mendapat pengobatan hormonal, yaitu masing-masing 69,3% dan 63,6% namun secara statistik tidak berbeda bermakna. Sebagai kesimpulan, penderita kanker prostat stadium II berusia lanjut lebih banyak yang mendapat pengobatan hormonal. Angka survival 5 tahun pada penderita yang mendapat radioterapi lebih baik daripada penderita yang diobati dengan cara lain walaupun tidak berbeda bermakna.Kata kunci: radioterapi, prostatektomi radikal, terapi hormonal, pengobatan berlebihan, pengobatan yang kurang.
Psikolojik Sermaye ve Örgütsel Adalet Algısının Akış Deneyimi Üzerindeki Etkisinde İşe Tutulmanın Aracılık Rolü: Türk Savunma Sanayinde Bir Araştırma
Authors: AKIN Kutay
Published: June 2022

Bu araştırmada, örgütsel adalet algısı ve psikolojik sermayenin, akış deneyimi üzerindeki etkisi ve bu etkiye işe tutulmanın aracılık edip etmediği irdelenmiştir. Araştırmanın örneklemini, ciroları itibariyle Türk Savunma Sanayini temsil eden kurumsal özel işletmelerin 533 çalışanı oluşturmaktadır. Araştırmanın değişkenlerini ölçmek amacı ile; Utrecht İşe Tutulma Ölçeği Kısa Formu, Psikolojik Sermaye Ölçeği Kısa Formu, Örgütsel Adalet Ölçeği ve Akış Deneyimi Ölçeği kullanılmıştır. Elde edilen veriler; demografik veriler ve tanımlayıcı istatistiklerin analizi; değişkenler arası anlamlılıkların sınanması; ölçüm modeli ve yapısal modelin test edilmesi gibi üç aşamalı bir analize tabi tutulmuştur. Analizler ışığında, işe tutulma davranışının anlamlı şekilde akış deneyimine öncül olduğu, bu kapsamda psikolojik sermaye ve örgütsel adalet algısı ile akış deneyimi ilişkisine aracılık ettiği görülmüştür. Örgütsel adalet algısının akış deneyimi ile anlamlı bir ilişkisi olmadığı ancak, işe tutulma üzerinden akışı etkilediği sonucuna varılmıştır. İşe tutulma ve akış deneyiminin alt boyutları itibari ile birbirlerine yakın kavramlar olduğu ancak belirli şekilde birbirinden ayrıştığı da görülmüştür.
Spor Taraftarı Aşk ve Nefret Ölçeği ile Spor Takımı Lisanslı Ürün Satın Alma Niyeti Ölçeğinin Geçerlik Güvenirlik Çalışması
Authors: Özsoy Ahmet , Karlı Ünal
Published: June 2022

Bu çalışmanın amacı “Spor Taraftarı Aşk ve Nefret” ve “Spor Takımı Lisanslı Ürün Satın Alma Niyeti” ölçeklerinin Türkçe formunun geçerlik ve güvenirliğini test etmek ve spor taraftarlarının takımlarına olan bağlılıkları, lisanslı takım ürünü satın alma niyetleri, gelir düzeyleri ve taraftarlık düzeyleri arasındaki ilişkiyi incelemektir. Araştırmanın örneklemini ölçüt örnekleme yöntemiyle seçilen 51 kadın (%28,3), 129 erkek (%71,7) olmak üzere toplam 180 üniversite öğrencisi oluşturmaktadır. Çalışmada “Spor Taraftarı Aşk ve Nefret Ölçeği” ve “Spor Takımı Lisanslı Ürün Satın Alma Niyeti Ölçeği” nin Türkçe formu ve araştırmacılar tarafından geliştirilen katılımcıların taraftarlık düzeylerini ve gelir seviyelerini sorgulayan kişisel bilgiler bölümü veri toplama araçlarını oluşturmuştur. Ölçeklere geçerlik ve güvenirlik analizleri uygulanmıştır. İstatistiksel bulgular her iki ölçeğinde geçerlik ve güvenirlik analizlerinde referans ölçütleri sağladığını ortaya koymuştur. Ayrıca taraftarın, taraftarlık seviyesi ile kendi takımına yönelik aşkı, taraftarlık seviyesi ile ezeli rakibi olan takıma yönelik nefreti ve taraftarlık seviyesi ile spor takımı lisanslı ürün satın alma niyeti arasında istatistiksel olarak pozitif anlamlı ilişki saptanmıştır. Bununla birlikte, taraftarların takımlarına duydukları aşk ve ezeli rakibine duydukları nefret ile taraftarı oldukları takımın lisanslı ürününü satın alma niyetleri arasında istatistiksel olarak pozitif anlamlı ilişki tespit edilmiştir. Sonuç olarak, Spor Taraftarı Aşk ve Nefret Ölçeği ile Spor Takımı Lisanslı Ürünü Satın Alma Niyeti Ölçeğinin Türk popülasyonu üzerinde yapılacak çalışmalarda kullanılabilecek geçerli ve güvenilir ölçekler olduğu ve taraftarın taraftarı olduğu takımın lisanslı ürünlerini satın alma niyetinin takımına duyduğu aşk ve ezeli rakibi olan takıma hissettiği nefret duyguları ile ilişkili olduğu ortaya konmuştur.
Performa Mesin Pencacah Pelepah Kelapa Sawit dengan Sistem Rotary
Authors: Arriyani Yang Fitri , Idiar Idiar , Subkhan Subkhan , Dwi Krishnaningsih Shanty
Published: June 2022

Pemanfaatan limbah pelepah sawit dapat diolah sebagai pakan ternak, kompos, pembuatan briket, dan bahan dasar panel komposit. Pemanfaatan limbah pelepah kelapa sawit untuk berbagai tujuan tersebut diproses dengan cara mencacahnya menjadi cacahan berukuran kecil. Proses pencacahan dengan menggunakan mesin pencacah memberikan kemudahan bagi petani dan mempercepat waktu pencacahan. Beberapa penelitian telah dilakukan pada proses pencacahan pelepah daun kelapa sawit  dengan menggunakan motor penggerak yang berbeda-beda dan berbagai model pisau potong, daya motor, serta kecepatan putaran motor yang bervariasi dengan tujuan untuk mendapatkan kapasitas efektif mesin yang optimal. Metode perancangan yang digunakan dalam pembuatan mesin adalah metode Pahl Beitz, yaitu perencanaan, perancangan konsep produk, perancangan bentuk, dan perancangan detail. Parameter yang diamati dan diukur pada mesin adalah kapasitas efektif mesin, rendemen cacahan, dan ukuran panjang hasil cacahan. Uji coba dilakukan sebanyak tiga kali pengulangan dengan mencacah pelepah yang ditimbang masing-masing seberat 5 kg. Hasil uji coba terhadap mesin pencacah pelepah kelapa sawit sistem rotary menunjukkan bahwa kapasitas efektif mesin rata-rata adalah sebesar 244,06 kg/jam sehingga termasuk dalam kategori kelas A. Rendemen cacahan rata-rata pada mesin adalah sebesar 97 % dan ukuran rata-rata cacahan ? 50 mm adalah sebesar 89,5 % dan telah memenuhi syarat SNI 7580 : 2010.
A Self-Resolving Flare of Psoriasis after COVID-19 Vaccination
Authors: Kaur Ikwinder , Bansal Pankaj
Published: June 2022

Flares of autoimmune disorders have been rarely reported after COVID-19 infection as well as vaccinations. The authors report a case of psoriasis flare after COVID-19 vaccination, which was successfully treated with topical steroids. This case illustrates that although autoimmune disease flares might be seen post-vaccination, they are usually mild and self-resolving. Therefore, based on overall safety and efficacy, COVID-19 vaccination is strongly encouraged in vulnerable patient populations.
PENGARUH PUPUK HAYATI CAIR DAN JARAK TANAM TERHADAP PERTUMBUHAN DAN HASIL TANAMAN KACANG TANAH ( Arachis hypogaea L. ) VARIETAS TALAM 1
Authors: Kurnia Asep , Jaenudin Amran , Sungkawa Iman
Published: June 2022

This study aimed to: (1) determine the effect of the interaction between liquid biofertilizer  and plant spacing on growth and yield of peanut (Arachis hypogea L.) varieties Talam 1, (2) determine the concentration of liquid biofertilizer that gives effect the best on the growth and yield of peanut (Arachis hypogea L.) varieties Talam 1, and  (3) determine the relationship between growth and yield components of peanut (Arachis hypogea L.) varieties Talam 1. The experiment was conducted from April until July 2018 at Sangkanurip Village, Cigandamekar District, Kuningan Regency. Located at a hight of 434,2 m above sea level.The method used in this study is the experimental method. The experimental design used was a randomized block design (RBD) factorial. The study consisted of two treatment factors, is the dose of biofertilizer concentration and the plant spacing repeated three times. The first factor, namely the concentration liquid biofertilizer consists of four levels, namely: K1 (concentration 0 ml / 1 liter of water) K2 (concentration 5 ml / 1 liter of water) K3 (concentration 10 ml / 1 liter of water) K4 (concentration 15 ml / 1 liter of water). The second factor is a spacing (J) consists of three levels, namely: J1 (30 x 15 cm), J2 (30 x 20 cm), and J3 (30 x 25 cm).The results showed that: (1) there is an interaction between liquid biofertilizer and plant spacing on plant height DAP age 41, fresh pods weight per hill, and the weight of dry pods per plot, (2) The treatment of concentration 10 ml / 1 liter of water (K3) and a spacing of 30 x 20 cm (J2) showed  the best effect on the weight of dry pods each plot which produces 1.43 kg/plot, equivalent to the average yield of 2,33 tons / ha, with assuming  80% effective field, (3) there is a significant correlation between plant height age 31, 41 DAP, number of leaves age 21, 41 DAP, leaf area index, and root volume with the weight of dry pods for each  plot.
PRODUKTIVITAS PADI PADA MUSIM PENGHUJAN DAN MUSIM KEMARAU DI WILAYAH DESA CIREBON GIRANG (Rice Productivity in The Rainy and Dry Seasons in The Cirebon Village Area)
Authors: Jaenudin Amran , Tadjudin E. , Parsetyo Meilina , Maryuliyanna Maryuliyanna
Published: June 2022

This research aims to determine the appropriate rice cultivation and cropping patterns in the rainy and dry seasons and to find out the analysis of rice farming in the rainy and dry seasons. The time of the research is from January to April 2019. The research location was in the village of Cirebon Girang, Talun District, Cirebon. The method used in this research is descriptive qualitative. The results showed that rice cultivation in the rainy and dry seasons experienced differences especially in fertilization, different plant disturbing organisms, different cropping patterns from the two farmer groups, as well as the highest farming business analysis in the Talun Makmur Rainy Season Farmer group Rp. 22,772,885 and the lowest farming business is the Tanjung Makmur farmer group. Rainy season Rp. 17,044,044. While the large profits obtained in the Talun Makmur Rainy season farmers group of Rp. 24,718,667.
PENGARUH PUPUK MIKRO MAJEMUK TERHADAP PEMBIBITAN TANAMAN KARET (Hevea Brasiliensis L) PADA TANAH INSEPTISOL JATINANGOR
Authors: Widayat Dedi , Umiyati Uum , Riswandi Dani , Deden Deden
Published: June 2022

Percobaan yang bertujuan untuk mengetahui efektivitas pupuk mikro majemuk Pupuk Mikro terhadap pertumbuhan tanaman karet dipembibitan pada tanah inceptisol Jatinangor telah dilaksanakan di Laboratorium Kultur Terkendali Fakultas Pertanian UNPAD pada bulan Januari sampai bulan September 2019. Pengujian mengunakan rancangan Acak Kelompok dengan 8 perlakuan diulang 4 kali. Perlakuan terdiri dari kontrol (tanpa pemupukan); NPK stndar; NPK+Pupuk Mikro 0,5 g/pohon; NPK+Pupuk Mikro 1,0 g/pohon; NPK+Pupuk Mikro 1,5 g/pohon; NPK+Pupuk Mikro 2,0 g/pohon; NPK+Pupuk Mikro 2,5 g/pohon, NPK+Pupuk Mikro 3,0 g/pohon. Hasil pengujian menunjukan Aplikasi pupuk mikro dengan dosis 1,5 sd 2,5 g/pohon dapat meningkatkan tinggi tanaman, diameter batang, bobot segar dan bobot keing bibit tanaman karet sampai 6 BST. Aplikasi pupuk mikro dengan dosis 2 g/pohon efektif meningkatkan bobot tanaman karet umur 6 BST di pembibitan pada tanah inseptisol asal jatinangor, dibandingkan dengan perlakuan pupuk NPK standar dengan nilai RAE 151 %.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PERMINTAAN IKAN PADA TINGKAT RUMAH TANGGA (Kasus di Desa Kaliwulu Kecamatan Plered Kabupaten Cirebon)
Authors: Faqih Achmad , Rangga Kordiana K
Published: June 2022

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi permintaan ikan pada tingkat rumah tangga di Desa Kaliwulu Cirebon. Penelitian ini dilakukan di Desa Kaliwulu Kecamatan Plered Kabupaten Cirebon pada bulan Januari-Maret 2019. Metode dasar yang digunakan adalah analisis deskriptif. Lokasi penelitian dilakukan secara pusposive di Desa Kaliwulu. Data yang dikumpulkan berupa data primer yang diperoleh menggunakan kuesioner. Pengambilan sampel dilakukan secara incidental sampling, sebesar 30 responden konsumen ikan, analisis data menggunakan analisis asumsi klasik dan analisis regresi linier berganda, analisis koefisien determinasi (R2) dan analisis pengujian hipotesis. Hasil penelitian menunjukkan bahwa faktor yang mempengaruhi permintaan ikan pada tingkat rumah tangga adalah harga ikan dengan nilai sig yaitu 0,001 < 0,05 dan jumlah tanggungan keluarga dengan nilai sig yaitu 0,015 < 0,05 sedangkan untuk faktor yang tidak berpengaruh adalah faktor pendapatan dengan nilai sig yaitu 0,189< 0,05. Sedangkan untuk nilai R2 adjusted sebesar 0,431 yang berarti proporsi sumbangan variabel bebas terhadap variabel terkait sebesar 43,1%, sedangkan sisanya sebesar 56,9% dijelaskan oleh variabel lain diluar penelitian seperti selera dan harga barang lain. Berdasarkan uji parsial (uji t) variabel harga ikan dan jumlah tanggungan keluarga berpengaruh nyata terhadap permintaan ikan.
AN INQUIRY INTO EFL LEARNERS� PERCEPTIONS OF WHATSAPP FOR ORAL PEER ASSESSMENT
Authors: Wulandari Ika , Purwati Oikurema , Setiawan Slamet , Anam Syafi'ul
Published: June 2022

The current global pandemic triggers English teachers to be innovative and competent in delivering teaching instructions in online classrooms. Even though Mobile-Assisted Language Learning (MALL) is widely used to support online language teaching and learning, nonetheless, the integration of Mobile-Assisted Language Assessment (MALA) in speaking skills has not been immensely examined. Thus, this current study aimed to scrutinize Indonesian EFL learners perceptions of the use of WhatsApp as a tool for peer assessment in an online speaking class, as well as its potential benefits and drawbacks. This qualitative study employed a semi-structured interview to gain the data which were then analyzed by using phenomenological analysis. Fourteen secondary learners participated in two sessions of an online class by assessing their peers oral performances via the WhatsApp application. In the end, they were interviewed regarding their views on the method employed to assess their oral skills. The results indicated the participants positive perceptions towards the method along with various benefits and drawbacks they encountered during the process which were divided into technical and academic aspects. The results suggested that WhatsApp as a tool for mobile-assisted language assessment was not supposed to be perceived as a single major assessment for speaking skills, rather as an alternative to complement traditional assessments.
Using Podcast Media on Teaching Listening in New Normal Era
Authors: Fatika Nenna Firmi , Rahayu Endang Mastuti
Published: June 2022

The objective of this study was to describe the application of using podcast media on the teaching listening. The students did not interest and experience difficulty while learning listening because the media of listening was too monotonous and lack of innovation. Podcast is a combination of two words namely "iPod" (the name of a brand) and broadcast. This is a medium in the form of sound or video that can be accessed and followed via internet. This study used qualitative appoarch. The subject of this study was the 10th grade students on X sosbas 1(b) class of Antartika Sidoarjo Senior High School with total 15 students. In this study, researcher used participant observation, questionnaire and interview as a data collection techniques. The data of this study analyzed using data reduction, data display and conclusion drawing. Based on the result of participant observation, questionnaire and interview, it can be seen that the use of podcast in learning listening made the students easier to understand the material and the students felt happy and comfort while learning listening.Keywords: Podcast, teaching listening, new normal era
UNDERGRADUATE STUDENTS� EXPERIENCES ON ONLINE LEARNING DUE TO COVID-19 PANDEMIC: THE INFLUENCE OF ENGAGEMENT AND PEDAGOGICAL CHARACTERISTIC IN EFL CONTEXT
Authors: Nurhadi Kardi , Putri Sister Ninda , Wati Atikah
Published: June 2022

This study is aimed to report undergraduate students experiences on online learning due to the Covid-19 pandemic. While online learning is not new, this was a novel and sudden experience for students who normally attend school, relatively little empirical evidence explore how undergraduate students experience during online learning due to the Covid-19 pandemic in terms of their engagement and pedagogical aspects. To fill this gap, this present study focused on investigating undergraduate students' experience of online learning in engagement included students active involvement category and pedagogical characteristics such as personalization, authenticity, and collaboration. Grounded in qualitative approach with phenomenological case study design. Out of thirty-one undergraduate students of 2nd semester major in English education in one of universities in West Java, three undergraduate students were recruited as the participants voluntarily in this study. The data were collected from online interviews adopting the three-interview series framework by Seidmans (2013) consisting of thirteen questions. The data were qualitatively analyzed by inductive phenomenological reduction from Seidmans (2013). The result of this study showed two emergent findings on undergraduate students' experience during online learning. First of all, the term of engagement on online learning of undergraduate students shows that each participant has a wide range of class involvement. Secondly, the pedagogical characteristic of personalization aspect indicated that students have independent learning such as read repeatedly the material and access more than one learning source.
Note on the Odd Perfect Numbers
Authors: Vega Frank
Published: June 2022

The Riemann Hypothesis is a conjecture that the Riemann zeta function has its zeros only at the negative even integers and complex numbers with real part $\frac{1}{2}$. Under the assumption of the Riemann Hypothesis, we prove that there is not any odd perfect number at all.
Concepções das professoras do atendimento educacional especializado com foco em crianças dos centros de educação infantil
Authors: Cordeiro Aliciene Fusca Machado , Steiner Daiana Rabock
Published: June 2022

Este artigo teve como principal objetivo discutir a concepção de professoras do Atendimento Educacional Especializado (AEE) que atuam na Educação Infantil sobre infância, aprendizagem e desenvolvimento e como essas concepções relacionam-se com o seu trabalho no AEE. Para a coleta de dados utilizou-se entrevista semiestruturada com cinco professoras do AEE, usando a análise de conteúdo para a interpretação dos dados. Utilizaram-se para a fundamentação teórica os seguintes autores: Sarmento e Pinto (1997), Tebet (2013), Baptista (2013), entre outros. Por meio da análise dos relatos percebeu-se uma urgência em reconhecer a infância como um processo histórico e cultural e a necessidade de superação de uma visão patológica da deficiência.
Jogos eletrônicos e aprendizagem: aspectos motivacionais na percepção de jovens jogadores
Authors: Ramos Daniela Karine
Published: June 2022

Este trabalho tem o objetivo discutir os aspectos motivacionais presentes nos jogos eletrônicos e suas relações com a aprendizagem, apontando para possíveis contribuições às dinâmicas do contexto escolar. A pesquisa realizada caracteriza-se por ser um estudo exploratório e qualitativo, utilizando como procedimentos para coleta a observação naturalística e a entrevista. A partir disso, descrevem-se aspectos relacionados à atratividade dos jogos – a satisfação de desejos, a competição e a superação de desafios – e as contribuições à aprendizagem – a contextualização do conteúdo, a proposição de problemas e o exercício da autonomia.
O vir a ser e o trágico pós-moderno
Authors: Maffesoli Michel , Barros Eduardo Portanova
Published: June 2022

O vir a ser e o trágico pós-moderno
O tornar-se arte do público. A obra, a massa e a mídia depois da sociedade do espetáculo
Authors: Susca Vincenzo
Published: June 2022

O princípio moderno da criação – seja artística, produtiva ou espetacular – reside na separação entre o indivíduo e a matéria; dito de outra forma, entre o público e a obra. Isso impõe, de um lado, o sacrifício do trabalhador em nome do objeto, e, de outra, a reverência ou a subordinação do público diante do espetáculo, mesmo na sua versão entertainment. A obra surge aqui como resultado de alienação da massa trabalhadora ou como a incorporação do público no interior desse cenário. Se não existe mercadoria sem o apagamento do operário, também existe o espetáculo sem uma espécie de aniquilamento do espectador. A criação da obra corresponde, pois, ao desaparecimento do sujeito no seio do dispositivo material e imaterial, ao seu esboroamento. Ao contrário, a cultura digital, epifenômeno do imaginário contemporâneo, tende a abolir a separação que acabamos de escrever. Como? Com quais resultados? O que se tornou a obra de arte à época de sua reprodutibilidade digital?
Ensino de Matemática e tecnologia digital: concepções de estudantes de Pedagogia e de professores dos anos iniciais
Authors: Souza Ana Paula Gestoso de , Passos Cármen Lúcia Brancaglion
Published: June 2022

Apresenta-se e analisam-se as concepções manifestas em narrativas elaboradas por licenciandos em Pedagogia e professores dos anos iniciais do Ensino Fundamental sobre a integração entre tecnologia digital e o ensino de matemática. A análise dos depoimentos possibilitou destacar as seguintes concepções: a) as tecnologias devem ser inseridas na escola, pois estão presentes na sociedade, b) os recursos tecnológicos podem promover a motivação dos estudantes para a realizarem as atividades, c) as escolas devem oferecer infraestrutura e propiciar a capacitação dos docentes para o uso das tecnologias, d) os avanços tecnológicos requerem mudanças no papel e na prática docente, e) os recursos tecnológicos não substituem o professor, f ) os professores podem utilizar as ferramentas tecnológicas para abordar os conteúdos de diferentes formas, g) os estudantes precisam aprender a ler criticamente as informações. A partir das análises dos dados apontam-se alguns elementos a serem considerados em cursos de formação objetivando que os cursistas explicitem, analisem e (re)signifiquem suas concepções.
A Review of Bioactive Compounds in Oyster Shell and Tissues
Authors: Ulagesan Selvakumari , Krishnan Sathish , Nam Taek-Jeong , Choi Youn-Hee
Published: June 2022

Oysters are saltwater bivalves with high nutritional and medicinal value that are consumed widely around the world. As well as being highly nutritious, oysters are a low-calorie, low-cholesterol source of protein and an exceptional source of zinc, which strengthens the immune system; and a rich source of bioactive compounds, which comprise various biological activities. The present review summarizes the biological applications and bioactive compounds from oyster shells, whole tissue, gill tissue, and mantle tissue. The various biological compounds present in an oyster shell, and their chemical constituents, have applications in the food, pharmaceutical, and medical industries. Bioactive peptides and proteins obtained from the whole, mantle, and gill tissues of oysters exhibit antioxidant, antimicrobial, antihypertensive, anticancer, antifatigue, anticoagulant, and anti-wrinkle effects, as well as enhance osteoblast differentiation. This review clearly shows that oysters have great potential for functional food production and that various compounds therein can have pharmaceutical applications.
ARPC2: A Pan-Cancer Prognostic and Immunological Biomarker That Promotes Hepatocellular Carcinoma Cell Proliferation and Invasion
Authors: Huang Shenglan , Dong Cairong , Li Dan , Xu Yongkang , Wu Jianbing
Published: June 2022

Background: Actin-related protein 2/3 complex subunit 2 (ARPC2) plays a fundamental role in actin filament nucleation and is critical for tumor cell migration and invasion. However, its abnormal expression, clinical significance, and biological function in human pan-cancer have been poorly explored. Thus, we focused on ARPC2 as an entry point for identifying novel pan-cancer prognostic biomarkers.

Methods: The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases were used to assess the differential expression of ARPC2 in pan-cancer. The Human Protein Atlas was used for the tissue/cell-specific expression analysis of ARPC2. The genetic alteration information of ARPC2 was obtained from the cBioPortal database and the GSCALite platform. The prognostic value of ARPC2 was explored in pan-cancer using Cox regression and Kaplan–Meier analyses. Spearman correlation analysis was performed to investigate the relationship between ARPC2 expression and tumor mutational burden (TMB), DNA methyltransferases, microsatellite instability (MSI), immune-related genes, and mismatch repairs (MMRs). The ESTIMATE and CIBERSORT algorithms were used to evaluate the association between ARPC2 expression and the tumor microenvironment (TME) and immune infiltrating cells. We also conducted differential expression analysis of ARPC2 in hepatocellular carcinoma (HCC) tissues and cell lines using qPCR, western blotting, and immunohistochemistry and explored its role in tumor proliferation, migration, and invasion of HCC cells.

Results: ARPC2 expression was significantly upregulated in multiple tumor types and significantly correlated with worse prognosis and higher clinicopathological stage. Genetic alterations and DNA methylation in tumor tissues may contribute to the aberrant expression of ARPC2. ARPC2 expression was significantly correlated with the tumor microenvironment (TME), infiltrating immune cells, TMB, microsatellite instability (MSI), and immune checkpoint-related genes in certain cancer types. In this experimental study, we found that the expression of ARPC2 was dramatically upregulated in HCC tissues and cell lines compared to adjacent liver tissues and normal liver cell lines. Functionally, ARPC2 silencing in HCC cells significantly inhibited cell proliferation, migration, and invasion, while the overexpression of ARPC2 promotes tumor proliferation, migration, and invasion.

Conclusion: ARPC2 is a promising prognostic and immunological biomarker for multiple tumor types and is likely to play an important role in HCC progression and metastasis.
Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy
Authors: Leifeld Jennifer , Förster Eckart , Reiss Gebhard , Hamad Mohammad I. K.
Published: June 2022

The extracellular matrix (ECM) of the nervous system can be considered as a dynamically adaptable compartment between neuronal cells, in particular neurons and glial cells, that participates in physiological functions of the nervous system. It is mainly composed of carbohydrates and proteins that are secreted by the different kinds of cell types found in the nervous system, in particular neurons and glial cells, but also other cell types, such as pericytes of capillaries, ependymocytes and meningeal cells. ECM molecules participate in developmental processes, synaptic plasticity, neurodegeneration and regenerative processes. As an example, the ECM of the hippocampal formation is involved in degenerative and adaptive processes related to epilepsy. The role of various components of the ECM has been explored extensively. In particular, the ECM protein reelin, well known for orchestrating the formation of neuronal layer formation in the cerebral cortex, is also considered as a player involved in the occurrence of postnatal granule cell dispersion (GCD), a morphologically peculiar feature frequently observed in hippocampal tissue from epileptic patients. Possible causes and consequences of GCD have been studied in various in vivo and in vitro models. The present review discusses different interpretations of GCD and different views on the role of ECM protein reelin in the formation of this morphological peculiarity.
Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research
Authors: Kent Robyn S. , Briggs Emma M. , Colon Beatrice L. , Alvarez Catalina , Silva Pereira Sara , De Niz Mariana
Published: June 2022

In the age of big data an important question is how to ensure we make the most out of the resources we generate. In this review, we discuss the major methods used in Apicomplexan and Kinetoplastid research to produce big datasets and advance our understanding ofPlasmodium, Toxoplasma, Cryptosporidium, TrypanosomaandLeishmaniabiology. We debate the benefits and limitations of the current technologies, and propose future advancements that may be key to improving our use of these techniques. Finally, we consider the difficulties the field faces when trying to make the most of the abundance of data that has already been, and will continue to be, generated.
Antiviral Effects and Underlying Mechanisms of Probiotics as Promising Antivirals
Authors: Wang Yanjin , Moon Assad , Huang Jingshan , Sun Yuan , Qiu Hua-Ji
Published: June 2022

Probiotics exert a variety of beneficial effects, including maintaining homeostasis and the balance of intestinal microorganisms, activating the immune system, and regulating immune responses. Due to the beneficial effects of probiotics, a wide range of probiotics have been developed as probiotic agents for animal and human health. Viral diseases cause serious economic losses to the livestock every year and remain a great challenge for animals. Moreover, strategies for the prevention and control of viral diseases are limited. Viruses enter the host through the skin and mucosal surface, in which are colonized by hundreds of millions of microorganisms. The antiviral effects of probiotics have been proved, including modulation of chemical, microbial, physical, and immune barriers through various probiotics, probiotic metabolites, and host signaling pathways. It is of great significance yet far from enough to elucidate the antiviral mechanisms of probiotics. The major interest of this review is to discuss the antiviral effects and underlying mechanisms of probiotics and to provide targets for the development of novel antivirals.
Applying Meta-Learning and Iso Principle for Development of EEG-Based Emotion Induction System
Authors: Miyamoto Kana , Tanaka Hiroki , Nakamura Satoshi
Published: June 2022

Music is often used for emotion induction. ince the emotions felt when listening to it vary from person to person, customized music is required. Our previous work designed a music generation system that created personalized music based on participants' emotions predicted from EEG data. Although our system effectively induced emotions, unfortunately, it suffered from two problems. The first is that a long EEG recording is required to train emotion prediction models. In this paper, we trained models with a small amount of EEG data. We proposed emotion prediction with meta-learning and compared its performance with two other training methods. The second problem is that the generated music failed to consider the participants' emotions before they listened to music. We solved this challenge by constructing a system that adapted an iso principle that gradually changed the music from close to the participants' emotions to the target emotion. Our results showed that emotion prediction with meta-learning had the lowest RMSE among three methods (p < 0.016). Both a music generation system based on the iso principle and our conventional music generation system more effectively induced emotion than music generation that was not based on the emotions of the participants (p < 0.016).
Spatiotemporal Discharge Variability of the Doce River in SE Brazil During MIS 6 and 5
Authors: Arndt Iris , Voigt Silke , Petschick Rainer , Hou Alicia , Raddatz Jacek , Albuquerque Ana Luiza S. , Bahr André
Published: June 2022

The modern precipitation balance in southeastern (SE) Brazil is regulated by the South American summer Monsoon and threatened by global climate change. On glacial-interglacial timescales, monsoon intensity was strongly controlled by precession-forced changes in insolation. To date, relatively little is known about the spatiotemporal distribution of tropical precipitation in SE Brazil and the resulting variability of fluvial discharge on glacial-interglacial timescales. Here, we present X-ray diffraction-derived mineralogical data for the 150–70 ka period (marine isotope stage (MIS) 6 to MIS 5) from the Doce River basin. This area was sensitive to changes in monsoonal precipitation intensity due to its proximity to the South Atlantic Convergence Zone. The data, obtained from a marine sediment core (M125-55–7) close to the Doce river mouth (20°S), show pronounced changes in the Doce River suspension load’s mineralogical composition on glacial-interglacial and precessional timescales. While the ratio of silicates to carbonates displays precession-paced changes, the mineralogical composition of the carbonate-free fraction discriminates between two assemblages which strongly vary between glacial and interglacial time scales, with precession-forced variability only visible in MIS 5. The first assemblage, dominated by high contents of kaolinite and gibbsite, indicates intensified lowland erosion of mature tropical soils. The second one, characterized by higher contents of the well-ordered illite, quartz and albite, points to intensified erosion of immature soils in the upper Doce Basin. High kaolinite contents in the silicate fraction prevailed in late MIS 6 and indicate pronounced lowland soil erosion along a steepened topographic gradient. The illite-rich mineral assemblage was more abundant in MIS 5, particularly during times of high austral summer insolation, indicating strong monsoonal rainfall and intense physical erosion in the upper catchment. When the summer monsoon weakened in times of lower insolation, the mineral assemblage was dominated by kaolinite again, indicative of lower precipitation and runoff in the upper catchment and dominant lowland erosion.
A Study on the Inhomogeneous Sedimentation—Diagenesis– Reservoir Formation Mode of Deep Tight Marine Clastic Rock Reservoirs in the Silurian Xiaoheba Formation, Southeast Sichuan
Authors: Cheng Lixue
Published: June 2022

By means of thin section authentication, physical characteristics analysis, scanning electron microscopy (SEM), X-ray diffraction, and vitrinite reflectance analysis, this paper, based on regional geological research achievements, studies the sedimentary facies and diagenesis of the southern and northern Silurian Xiaoheba Formation areas of Southeast Sichuan and their relationships with the physical characteristics of the reservoirs. The results indicate that, in the northern study area, the microfacies are mainly deposited in the underwater distributary main channel of the distal shallow-water delta front; while in the south, the microfacies include an estuary bar, sheet sand, distal bar, and interdistributary bay, which are far away from the main channel. The physical characteristics of sandstone are positively correlated with its particle sizes and thickness. The sand body of the underwater distributary main channel microfacies features high porosity, large crack opening, and good connectivity, followed by the sandstone of the estuary bar microfacies regarding those characteristics. By contrast, the physical characteristics of the sandstone reservoirs corresponding to the microfacies including the distal bar, sheet sand, and interdistributary bay are poor. The Xiaoheba Formation reservoir is located in the late diagenetic stage, with the reservoir space dominated by dissolved pores and micro-cracks; the diagenesis and pore evolution in the south are significantly different from those in the north. The Xiaoheba Formation reservoir in the northern area is far away from the carbonate rock platform of the same period in the south but is close to the center of hydrocarbon generation. Besides, the reservoir was sufficiently reformed by organic acid dissolution in the early-medium diagenetic stage, with only a little carbonate cementation formed in the early stage, while the cementation in the late diagenetic stage was weak. Therefore, the reservoir pores were relatively well preserved. However, the Xiaoheba Formation reservoir in the southern area has a large amount of calcite cement that was formed in the early diagenetic stage and the pores were blocked due to the influence of the carbonate platform. Since the dissolution was weak at the same time, the reservoir in the southern area is tight. Based on the understanding above, this paper established the inhomogeneous sedimentation–diagenesis–reservoir formation mode of the northern and southern areas of the study area.
Experimental Study on Mechanical Properties of Gas Storage Sandstone and Its Damage Under Temperature and Pressure
Authors: Wang Xiaoping , Wang Lehua , Zhao Baoyun , Wu Yingjie , Yang Jiaosheng , Sun Junchang
Published: June 2022

With the ever-increasing demand for energy, energy mining is developing in the deep underground. In this paper, a conventional triaxial test and a triaxial test at different temperatures (45 MPa confining pressure) have been carried out for sandstone in Hutubi gas storage, and the mechanical properties of the sandstone at different temperatures are analyzed. Based on the damage theory, the damaged relationship of sandstone under thermal-mechanical coupling is deduced, and the damage evolution law of sandstone in gas storage is analyzed. The results show that: 1) In the conventional triaxial test, as the confining pressure increases, the peak strength and elastic modulus of the sandstone are higher, and the specimen is partially sheared and damaged. 2) In the triaxial test under the effect of temperature, the peak strength of the sample decreases with the increase of temperature. Compared with the four stages of the conventional triaxial test, the stress-strain curve adds a ductility stage. The failure mode of the sample is mainly micro-cracks extended ductile destruction. 3) Under the thermal-mechanical coupling of sandstone, the higher the test temperature, the greater the initial damage of the sample. With the joint action of axial force and temperature, the damage of specimen becomes more obvious. This research results can provide the experimental basis and mechanism understanding for the analysis of mechanical properties of gas storage sandstone and the application of deep underground engineering.
The Reproductive Outcome of Women with Hypogonadotropic Hypogonadism in IVF
Authors: Zhang Chun-mei , Zhang Hua , Yang Rui , Chen Li-xue , Liu Ping , Li Rong , Qiao Jie , Wang Ying
Published: June 2022

Objective

The purpose of this study was to evaluate the reproductive outcome of patients with hypogonadotropic hypogonadism (HH) receiving in vitro fertilization and embryo transfer (IVF-ET).

Methods

The reproductive outcome of 81 HH patients and 112 controls who underwent oocyte retrieval was evaluated retrospectively in the Center for Reproductive Medicine of Peking University Third Hospital from 2010 to 2019.

Results

The basic levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), androstenedione (A) and prolactin (PRL) were significantly lower in the HH group than the control group. Although the HH patients required a significantly longer stimulation and higher gonadotropin (Gn) doses than the control patients, the total number of oocytes retrieved, fertilized embryos, two pronuclear (2PN) embryos, transferable embryos, fertilization and 2PN rates were comparable between the two groups. Although the live birth rate (LBR) of the first fresh cycle was higher in the control group than the HH group, there was no statistical significance. Then we further divided HH patients into two subgroups according to the etiology. Forty-one cases were termed as congenital HH (CHH), while the other 40 cases were termed as acquired HH (AHH), the latter includes functional hypothalamic amenorrhea (FHA) and pituitary HH (PHH). Our results showed that there were no significant differences in basic clinical characteristics and IVF parameters between the two groups. In the HH group, a total of 119 oocyte retrieval cycles were carried out and they responded adequately to ovulation induction. Urinary human menopausal gonadotropin (HMG) was used alone in 90 cycles while combination of HMG and recombinant human follicle stimulating hormone (rFSH) in the other 29 cycles. There were no significant differences in IVF-related parameters between the two groups. The conservative cumulative live birth rates (CLBRs) after the first, the second and ≥third cycles were 43.21%, 58.02% and 60.49%, respectively, while the corresponding optimal CLBRs were 43.21%, 68.45% and 74.19%. The preterm birth (PTB) rates of singletons and twin pregnancy in HH patients were 8.33% (3/36) and 30.77% (4/13), respectively.

Conclusion

IVF-ET is an effective treatment for HH patients with infertility and patients can get satisfactory pregnancy outcomes.
Prevalence and Trends in Gestational Diabetes Mellitus Among Women in the United States, 2006–2017: A Population-Based Study
Authors: Zhou Tao , Du Shan , Sun Dianjianyi , Li Xiang , Heianza Yoriko , Hu Gang , Sun Litao , Pei Xiaofang , Shang Xiaoyun , Qi Lu
Published: June 2022

The prevalence of gestational diabetes mellitus (GDM) has increased with the increasing rate of obesity. However, national data on the prevalence and secular trends of GDM during the past decade in the United States are lacking. This study included 37,357 women aged more than 18 years and who had ever been pregnant from the National Health Interview Survey (NHIS). We examined GDM prevalence in 2006, 2016, and 2017, with age-standardized to the US population in 2000. We found that the prevalence of GDM per 100 people increased from 4.6 (95% CI, 4.1–5.1) in 2006 to 8.2 (95% CI, 7.5–8.9) in 2016 (test for difference; P <0.001), with a relatively increased rate of 78%. Non-Hispanic white women tended to have a lower increase (2.8%) than non-Hispanic black women (3.8%), Hispanic women (4.1%), and women of other race/ethnicity (8.4%). The prevalence of GDM in non-Hispanic white women was higher than that in non-Hispanic black women in 2006 (4.8% vs 3.5%, P = 0.006); such differences became non-significant in 2016 (P = 0.72). Additionally, the increase of GDM from 2006 to 2016 tended to be more evident among women who were overweight (25≤ BMI ≤30 kg/m2), physically inactive, and with family income below the poverty threshold than women in other BMI ranges, with more physical activity, and with higher incomes. The prevalence of GDM per 100 people in 2017 was 8.4 (7.6–9.2), and there was no significant change in the overall and subgroup prevalence compared with 2016. Collectively, in the United States, the prevalence of GDM continuously increased, nearly doubled, from 2006 to 2016, and then leveled off in 2017. The increase appeared more marked among the minority populations and subpopulations with overweight people, insufficient activity, and family incomes below the poverty threshold.
Prognostic Value of Cancer-Associated Fibroblast-Related Gene Signatures in Hepatocellular Carcinoma
Authors: Dong Wenge , Xie Yangyang , Huang Hai
Published: June 2022

Hepatocellular carcinoma (HCC) is a global health challenge with an increasing incidence worldwide. Cancer-associated fibroblasts (CAFs) function critically in HCC initiation and development. However, the prognostic significance of CAF-related gene signatures in HCC remains unknown. Therefore, the specific functions of CAF-related genes in HCC were investigated to help develop potential therapeutic strategies. In this study, CAF-related genes were screened from three CAF-related gene sets. HCC data from the Gene Expression Omnibus (GEO) database was applied to verify the screened CAF-related genes. Cluster analysis was used to identify clusters based on the expression pattern of CAF-related genes and two identified clusters were found to have a significant difference in overall survival (OS) and progression free intervals (PFI). The prognosis of HCC patients was predicted using the prognostic risk score model developed based on HCC data from The Cancer Genome Atlas (TCGA) databases. High-risk group patients had a worse OS than those in low-risk group in TCGA. These results were validated in International Cancer Genome Consortium (ICGC) database. Moreover, combining the clinicopathological characteristics related to prognosis with the model, a nomogram was built for a more accurate prediction of OS of HCC patients. In addition, analyses of immune infiltration characteristics of tumor microenvironment (TME), chemosensitivity, and immunotherapy response were conducted to further evaluate the prognostic value of CAF-related genes. Patients with low-risk scores were found to have higher chemosensitivity to cisplatin, doxorubicin, and sorafenib. Individuals with high-risk scores were found with a higher expression of most immune checkpoints which indicated patients with high-risk scores may benefit more from treatment with immune checkpoint inhibitors. Furthermore, a correlation between immune infiltration characteristics of TME and patients with different risk levels was found. These findings provide a possibility for the further development of personalized treatments in HCC.