bluuebunny/crossref_metadata_2025 huggingface dataset:
No clinical consequence of liner malseating in dual-mobility THAs at short term: a systematic review
Authors: Karczewski Daniel , Andronic Octavian , Akgün Doruk , Adelhoefer Siegfried , Kriechling Philipp , Bäcker Henrik
Published: April 2023

Background

Liner malseating is well described in ceramic-on-ceramic total hip arthroplasties (THAs). However, limited information is known on this complication among dual-mobility articulations. As such, this systematic review analyzed liner malseating in dual-mobility THAs concerning prevalence, clinical implications, and associated risk factors.

Methods

A PRISMA criteria-based systematic review was performed, and PubMed, Web of Science, MEDLINE, and Cochrane used as data bases. All original studies from 1980 to 2022 were considered eligible for inclusion, and Methodological Index for Nonrandomized Studies (MINORS) used for quality assessment.

Results

In total, five retrospective cohort studies with 2330 patients (2673 dual-mobility THAs) were included. Mean age was 66.9 years, mean BMI was 29.8 kg/m2, and 35% of patients were female. Rates of malseating ranged from 0.15% to 5.8%, with a total of 53 malseated liners identified throughout all studies (1.98%). Based on THA manufacturer, malseating occurred in 48 Stryker (1.96%) and 5 Biomet Zimmer (2.14%) THAs. Mean clinical follow-up was 2.2 years (mean range, 1.3 to 6.4 years). Except one patient reporting of pain at 2 years, no revision or negative clinical implication was noted in any of the malseated liners, including normal ranged metal ions measured in four cases. A smaller acetabular component size was identified as a statistically significant risk factor for malseating in one study. Mean MINORS score was 9.8.

Conclusions

Liner malseating is a rare finding in patients undergoing THAs with dual-mobility articulations. While prelim results demonstrate no negative clinical consequences to date, existing studies are limited, refer to short-term outcomes only, and do not prospectively follow-up affected patients.

Level of evidence: IV.
Chronobiological changes due to school closures during the COVID-19 pandemic among adolescents in the DOrtmund Nutritional and Anthropometric Longitudinally Designed cohort study
Authors: Perrar Ines , Alexy Ute , Jankovic Nicole
Published: April 2023

Due to the lockdown of schools as one of the COVID-19 control measures, adolescents have had the opportunity to re-organise their daily lives; e.g. some of them have adapted their bedtimes to the new situation during the lockdown in favour of their own chronotype. Hence, we investigated differences in chronobiological characteristics (e.g., the midpoint of sleep, sleep duration or social jetlag (SJL); i.e., a discrepancy between biological and social timing) before and during the pandemic lockdown to examine potential changes. We asked participants from the ongoing open cohort Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study to fill out the Munich Chronotype Questionnaire during the COVID-19 lockdown and received the information of participants (n = 66) during the pandemic. A reference group matched for age, season, and sex was randomly selected from the DONALD study to assess participants’ chronobiological characteristics prior to (n = 132) the pandemic. Analyses of covariance were applied to examine differences between the two groups reflecting the situation before and during the COVID-19 pandemic. Participants were aged 9–18 years (52% males). In the current examination, average sleep duration across the week was higher among adolescents during the pandemic (β = 00:30; p = 0.0006) and social jetlag was significantly lower (β =  −00:39; p < 0.0001).

Conclusion: Our results showed that the COVID-19 lockdown enabled adolescents to adapt their sleeping habits according to their naturally late chronotype, which led to a significant reduction in SJL. These observations are likely to be explained by the effect of school closure.

What is Known:• Under ‘normal conditions’ without pandemic lockdowns, adolescents accumulate a lack of sleep due to social obligations such as school starts, resulting in social jetlag.• A late chronotype or exposure to social jetlag is a known risk factor for the development of chronic diseases.

What is New:• The COVID-19 lockdown represents a ‘natural experiment’ that enables adolescents to adhere to their internal biological clock. Without the usual social obligations, social jetlag can be significantly reduced.
Differences in the intraspecies copy number variation of Arabidopsis thaliana conserved and nonconserved miRNA genes
Authors: Samelak-Czajka Anna , Wojciechowski Pawel , Marszalek-Zenczak Malgorzata , Figlerowicz Marek , Zmienko Agnieszka
Published: April 2023

MicroRNAs (miRNAs) regulate gene expression by RNA interference mechanism. In plants, miRNA genes (MIRs) which are grouped into conserved families, i.e. they are present among the different plant taxa, are involved in the regulation of many developmental and physiological processes. The roles of the nonconserved MIRs—which are MIRs restricted to one plant family, genus, or even species—are less recognized; however, many of them participate in the responses to biotic and abiotic stresses. Both over- and underproduction of miRNAs may influence various biological processes. Consequently, maintaining intracellular miRNA homeostasis seems to be crucial for the organism. Deletions and duplications in the genomic sequence may alter gene dosage and/or activity. We evaluated the extent of copy number variations (CNVs) among Arabidopsis thaliana (Arabidopsis) MIRs in over 1000 natural accessions, using population-based analysis of the short-read sequencing data. We showed that the conserved MIRs were unlikely to display CNVs and their deletions were extremely rare, whereas nonconserved MIRs presented moderate variation. Transposon-derived MIRs displayed exceptionally high diversity. Conversely, MIRs involved in the epigenetic control of transposons reactivated during development were mostly invariable. MIR overlap with the protein-coding genes also limited their variability. At the expression level, a higher rate of nonvariable, nonconserved miRNAs was detectable in Col-0 leaves, inflorescence, and siliques compared to nonconserved variable miRNAs, although the expression of both groups was much lower than that of the conserved MIRs. Our data indicate that CNV rate of Arabidopsis MIRs is related with their age, function, and genomic localization.
A vision of 14 T MR for fundamental and clinical science
Authors: Bates Steve , Dumoulin Serge O. , Folkers Paul J. M. , Formisano Elia , Goebel Rainer , Haghnejad Aidin , Helmich Rick C. , Klomp Dennis , van der Kolk Anja G. , Li Yi , Nederveen Aart , Norris David G. , Petridou Natalia , Roell Stefan , Scheenen Tom W. J. , Schoonheim Menno M. , Voogt Ingmar , Webb Andrew
Published: April 2023

Objective

We outline our vision for a 14 Tesla MR system. This comprises a novel whole-body magnet design utilizing high temperature superconductor; a console and associated electronic equipment; an optimized radiofrequency coil setup for proton measurement in the brain, which also has a local shim capability; and a high-performance gradient set.

Research fields

The 14 Tesla system can be considered a ‘mesocope’: a device capable of measuring on biologically relevant scales. In neuroscience the increased spatial resolution will anatomically resolve all layers of the cortex, cerebellum, subcortical structures, and inner nuclei. Spectroscopic imaging will simultaneously measure excitatory and inhibitory activity, characterizing the excitation/inhibition balance of neural circuits. In medical research (including brain disorders) we will visualize fine-grained patterns of structural abnormalities and relate these changes to functional and molecular changes. The significantly increased spectral resolution will make it possible to detect (dynamic changes in) individual metabolites associated with pathological pathways including molecular interactions and dynamic disease processes.

Conclusions

The 14 Tesla system will offer new perspectives in neuroscience and fundamental research. We anticipate that this initiative will usher in a new era of ultra-high-field MR.
Progradation of a shallow carbonate platform developed on a fault-block in the Western Tethys (lower Aptian, Sierra de Bedmar-Jódar, Prebetic of Jaén, Spain)
Authors: Martínez-Rodríguez Rafael , Nieto Luis M. , Castro José M. , de Gea Ginés A. , Ruiz-Ortiz Pedro A. , Molina José M. , Skelton Peter W.
Published: April 2023

The Middle Member of the Llopis Fm in the Sierra de Bedmar-Jódar Unit of the Prebetic Zone of Jaén (southern Spain) was deposited on a shallow-marine platform of the Southern Iberian Continental Margin during the earliest Aptian. Detailed field logging of nine stratigraphic sections and facies mapping have allowed seven lithofacies associations (L1–L6) to be distinguished, one siliciclastic (L1) and five carbonate facies (L2–6). The succession is composed of eight consecutive elemental sequences of lithofacies associations L1–L6. Each elemental sequence is interpreted as representing one episode of shallowing-upwards carbonate deposition in a very shallow platform-lagoon that was bounded shoreward by clastic/ooid bars and passed seaward either to stromatoporoid bioconstructions (bioherms and biostromes) or rudist biostromes. The successive elemental sequences show north-eastward progradational geometries. Three phases of platform development are identified: (1) installation of the shallow platform; (2) development of a lagoon bounded by a stromatoporoid barrier and (3) development of an Urgonian-type platform dominated by rudists. During the early Aptian, the Bedmar-Jódar platform was partially isolated from the rest of the Prebetic platform and showed overall progradation towards the NE, in contrast to the general south-eastward progradational trend of the Prebetic platform. Sedimentation was controlled by rift-generated extensional tectonics that resulted in tilting of the platform block, causing the deviation of progradation from the general trends of the Prebetic Platform. In addition, climatic influence is inferred from the presence of siliciclastic sediments derived from weathering of the hinterland, which restricted the carbonate factory.
Residential building stock in Serbia: classification and vulnerability for seismic risk studies
Authors: Blagojević Nikola , Brzev Svetlana , Petrović Milica , Borozan Jovana , Bulajić Borko , Marinković Marko , Hadzima-Nyarko Marijana , Koković Veljko , Stojadinović Božidar
Published: April 2023

Regional seismic risk assessment is necessary for designing effective seismic risk mitigation measures. In general, such risk assessment studies consist of three components: hazard, vulnerability, and exposure modelling. This paper lays the foundations for regional seismic risk assessment of the residential building stock in Serbia and addresses each of the three seismic risk assessment components, either by reviewing the existing or proposing novel models. First, a review of seismic hazard models and seismic design codes used in Serbia in the past 70 years was presented. Next, an overview of Serbia’s population metrics and historical development of Serbian’s residential building stock was presented to provide the context for the exposure model. Furthermore, the paper proposed a novel building classification for Serbia's residential building stock, which is based on the existing building taxonomies, but it has been adapted to account for the local building characteristics. Building damage patterns reported in past earthquakes in Serbia and neighbouring countries were reviewed as a basis for damage classification pertaining to building typologies included in the proposed classification. Finally, the results of a preliminary vulnerability model were presented in the form of expert-based fragility functions derived for buildings typical of Serbia's residential building stock.
Temporal trend evaluation in monitoring programs with high spatial resolution and low temporal resolution using geographically weighted regression models
Authors: von Brömssen Claudia , Fölster Jens , Eklöf Karin
Published: April 2023

Data from monitoring programs with high spatial resolution but low temporal resolution are often overlooked when assessing temporal trends, as the data structure does not permit the use of established trend analysis methods. However, the data include uniquely detailed information about geographically differentiated temporal trends driven by large-scale influences, such as climate or airborne deposition. In this study, we used geographically weighted regression models, extended with a temporal component, to evaluate linear and nonlinear trends in environmental monitoring data. To improve the results, we tested approaches for station-wise pre-processing of data and for validation of the resulting models. To illustrate the method, we used data on changes in total organic carbon (TOC) obtained in a monitoring program of around 4800 Swedish lakes observed once every 6 years between 2008 and 2021. On applying the methods developed here, we identified nonlinear changes in TOC from consistent negative trends over most of Sweden around 2010 to positive trends during later years in parts of the country.
Air pollution modeling to support strategic environmental assessment: case study—National Emission Reduction Plan for coal-fired thermal power plants in Serbia
Authors: Josimović Boško , Todorović Dušan , Jovović Aleksandar , Manić Božidar
Published: April 2023

The paper presents a specific method of environmental impact assessment applied in Strategic Environmental Assessment (SEA) for the National Emission Reduction Plan (NERP) in the Republic of Serbia, based on air quality. The specificity of the approach is in the application of a semiquantitative method of multicriteria evaluation based on air dispersion modeling and the integration of SEA goals, indicators and criteria for assessing the impact of the NERP on the quality of air and other environmental elements in this method. When predicting changes in air quality for the planning horizon to 2028, the physical, geographical and climatic characteristics of the area were taken into account, as well as technical measures to reduce SO2 emissions, since this was the dominant pollutant from the Serbian coal-fired power plants studied by the NERP. Air pollution modeling was carried out using the AERMOD software package based on the data collected, and the quantitative results obtained were used in a multicriteria evaluation as part of the SEA. The results of the research indicated the importance of applying this approach in order to significantly increase objectivity in the SEA process, since it is an important element of decision making at the strategic level. In addition, a comparative presentation of the modeling results before and after application of the NERP was an important part of the SEA process, and it provided a clear insight into expected changes in the air quality. This is a key argument for making appropriate policy decisions on spatial, energy, environmental and socio-economic development in the Republic of Serbia, which, like other developing countries, is sluggishly following global trends in energy transition.
Nitrogen translocation by Highland cattle grazing in Alnus viridis-encroached pastures
Authors: Svensk Mia , Pittarello Marco , Mariotte Pierre , Nota Ginevra , Schneider Manuel K. , Frund David , Dubois Sébastien , Allan Eric , Probo Massimiliano
Published: April 2023

During the last decades, Alnus viridis has expanded over former montane pastures and meadows, due to land use and abandonment. This nitrogen-fixing woody species has triggered negative agro-environmental impacts, such as nitrogen (N) leaching, soil acidification and a reduced biodiversity. The aim of this study was to estimate the N translocation from A. viridis-encroached areas to adjacent open pastures by Highland cattle. In 2019 and 2020, Highland cattle herds equipped with GPS collars were placed in four A. viridis-encroached paddocks across Italy and Switzerland. The N content was measured in A. viridis leaves, herbaceous vegetation, and cattle dung pats, which were collected throughout the grazing season. Using GPS locations and collar activity sensors, livestock activity phases were discriminated. The N ingested by cattle was estimated through the N content of herbaceous vegetation and A. viridis leaves of vegetation patches visited by cattle during 24 h before dung sampling (N24H). The N content of herbaceous vegetation significantly increased with increasing A. viridis cover. The average N content in dung pats (31.2 ± 3.4 g.kg−1 DM) was higher than average values from literature on grazing cattle. Moreover, it was positively related to the N24H. Most of this N (29.5 ± 10.3 kg ha−1 yr−1) was translocated towards resting areas, which generally occurred on flat open pastures. Our results highlight the potential of Highland cattle to effectively translocate part of the ingested N from A. viridis-encroached towards targeted open areas, thus bringing new perspective for forage yield and quality improvement in the long-term.
Crisscrossing scapes in the global flow of elite mainland Chinese students
Authors: Woo Etienne , Wang Ling
Published: April 2023

This paper applies Appadurai’s notion of scapes in globalisation to study international student mobility. Thirty mainland Chinese students were interviewed; the majority of whom studied at prestigious institutions in the West before enrolling in their current PhD programmes at a research-intensive university in Hong Kong (HK) in the immediate aftermath of HK’s large-scale social protests and amidst the Covid-19 pandemic. We seek to understand why these students relocated to HK to further their studies given these turbulent circumstances and how their mainlander identity and sojourns in the West influence their perceptions of HK’s social movements from the perspectives of ethnoscape and ideoscape, respectively. Our findings reveal that HK represented the ‘best’ compromise for our participants, mitigating their nostalgia for home (i.e. mainland China) whilst offering a superior education to the Chinese mainland. Most participants perceived HK as a nationalistic ideoscape, wherein HK people’s pursuit of autonomy is subordinated to the putative Chinese national interests. Moreover, ethnoscape and ideoscape dynamics were found to crisscross other scapes. Generous scholarships (i.e. financescape) provided additional incentives driving student relocations. The persistent consumption of Chinese social media (techno-mediascape) was found to have resulted in worldview conformity between our participants and the Chinese state.
DESMILS: a decision support approach for multi-item lot sizing using interactive multiobjective optimization
Authors: Kania Adhe , Afsar Bekir , Miettinen Kaisa , Sipilä Juha
Published: April 2023

We propose a decision support approach, called DESMILS, to solve multi-item lot sizing problems with a large number of items by using single-item multiobjective lot sizing models. This approach for making lot sizing decisions considers multiple conflicting objective functions and incorporates a decision maker’s preferences to find the most preferred Pareto optimal solutions. DESMILS applies clustering, and items in one cluster are treated utilizing preferences that the decision maker has provided for a representative item of the cluster. Thus, the decision maker provides preferences to solve the single-item lot sizing problem for few items only and not for every item. The lot sizes are obtained by solving a multiobjective optimization problem with an interactive method, which iteratively incorporates preference information and supports the decision maker in learning about the trade-offs involved. As a proof of concept to demonstrate the behavior of DESMILS, we solve a multi-item lot sizing problem of a manufacturing company utilizing their real data. We describe how the supply chain manager as the decision maker found Pareto optimal lot sizes for 94 items by solving the single-item multiobjective lot sizing problem for only ten representative items. He found the solutions acceptable and the solution process convenient saving a significant amount of his time.
Antibacterial and pH-sensitive methacrylate poly-L-Arginine/poly (β-amino ester) polymer for soft tissue engineering
Authors: Heydari Parisa , Varshosaz Jaleh , Kharaziha Mahshid , Javanmard Shaghayegh Haghjooy
Published: April 2023

During the last decade, pH-sensitive biomaterials containing antibacterial agents have grown exponentially in soft tissue engineering. The aim of this study is to synthesize a biodegradable pH sensitive and antibacterial hydrogel with adjustable mechanical and physical properties for soft tissue engineering. This biodegradable copolymer hydrogel was made of Poly-L-Arginine methacrylate (Poly-L-ArgMA) and different poly (β- amino ester) (PβAE) polymers. PβAE was prepared with four different diacrylate/diamine monomers including; 1.1:1 (PβAE1), 1.5:1 (PβAE1.5), 2:1 (PβAE2), and 3:1 (PβAE3), which was UV cross-linked using dimethoxy phenyl-acetophenone agent. These PβAE were then used for preparation of Poly-L-ArgMA/PβAE polymers and revealed a tunable swelling ratio, depending on the pH conditions. Noticeably, the swelling ratio increased by 1.5 times when the pH decreased from 7.4 to 5.6 in the Poly-L-ArgMA/PβAE1.5 sample. Also, the controllable degradation rate and different mechanical properties were obtained, depending on the PβAE monomer ratio. Noticeably, the tensile strength of the PβAE hydrogel increased from 0.10 ± 0.04 MPa to 2.42 ± 0.3 MPa, when the acrylate/diamine monomer molar ratio increased from 1.1:1 to 3:1. In addition, Poly-L-ArgMA/PβAE samples significantly improved L929 cell viability, attachment and proliferation. Poly-L-ArgMA also enhanced the antibacterial activities of PβAE against both Escherichia coli (~5.1 times) and Staphylococcus aureus (~2.7 times). In summary, the antibacterial and pH-sensitive Poly-L-ArgMA/PβAE1.5 with suitable mechanical, degradation and biological properties could be an appropriate candidate for soft tissue engineering, specifically wound healing applications.

Graphical Abstract
Facilitated Subcutaneous Immunoglobulin Treatment in Patients with Immunodeficiencies: the FIGARO Study
Authors: Borte Michael , Hanitsch Leif G. , Mahlaoui Nizar , Fasshauer Maria , Huscher Dörte , Speletas Matthaios , Dimou Maria , Kamieniak Marta , Hermann Corinna , Pittrow David , Milito Cinzia
Published: April 2023

Purpose

The FIGARO study aims to provide insights on real-world utilization and tolerability of facilitated subcutaneous immunoglobulin (fSCIG) for primary immunodeficiency disease (PID) or secondary immunodeficiency disease (SID).

Methods

This prospective, multicenter, observational study, evaluated medical records, charts, and diaries of patients who had received at least 1 fSCIG infusion for PID or SID. Data were analyzed by cohort (PID, SID) and age groups (pediatric [< 18 years], adult [18–64 years], older adult [≥ 65 years]). Patients were followed up to 36 months.

Results

The study enrolled 156 patients: 15 pediatric, 120 adult, 21 older-adult. Twelve-month follow-up data were available for 128 patients. fSCIG was mainly prescribed for PID among patients aged < 65 years and for SID among older adults. At inclusion, 75.6% received their fSCIG infusion at home, and 78.7% self-administered. Adults were more likely to receive their initial infusion at home and self-administer (81.7% and 86.6%, respectively) than pediatric patients (53.3% each) and older adults (57.1% and 52.4%, respectively). At 12 months, the proportion of patients infusing at home and self-administering increased to 85.8% and 88.2%. Regardless of age, most patients self-administered the full fSCIG dose at home every 3–4 weeks and required a single infusion site. The tolerability profile was consistent with previous pivotal trials. Acute severe bacterial infections occurred in 0%–9.1% of patients during follow-up visits (full cohort).

Conclusions

FIGARO confirms the feasibility, tolerability, and good infection control of fSCIG in PID and SID patients across the age spectrum in both the home-setting and medical facility.

Trial registration number

ClinicalTrials.gov NCT03054181
The Devil’s in the Detail: Implementation Fidelity in Evaluating a School-Based Prevention Programme for Children Under 12
Authors: Kurdi Zain , Millar Annemarie , Barter Christine Anne , Stanley Nicky
Published: April 2023

Purpose

This paper examines implementation fidelity (IF) and the underpinning conceptual framework drawing on the evaluation of a UK-wide, manualized child abuse and neglect prevention program for elementary schools. We describe and assess our approach to assessing IF and consider how IF can inform program development.

Method

We drew on the literature on program fidelity and critical components of the program evaluated to identify three dimensions of IF: Coverage, Quality and Context. Data was collected through external observations using systemized observation schedules which were extracted to be scored using scoring protocols for each intervention type. Scores were calculated by two researchers with a random sample cross-checked by a third member of the research team.

Results

Observation analysis demonstrated consistency in the coverage of content when delivering assemblies for both younger and older children with at least 76% coverage of content across the assemblies. However, observation analysis revealed greater levels of variability in the delivery of workshops. Material on sexual abuse was less fully covered and children reported that some facilitators lacked confidence and clarity in delivering this material (Stanley et al., 2023).

Conclusion

Our results indicate the usefulness of systemized observations in capturing coverage of content, these findings underscore the importance of developing scoring protocols and training observers prior to evaluating program delivery. We highlight the significance of integrating implementation fidelity training for program facilitators and implementers to both assist with monitoring and to maintain quality, despite variations in the actual delivery and setting of the program.
A Decision Aid to Support Vocational Rehabilitation Professionals Offering Tailored Care to Benefit Recipients with a Long-Term Work Disability: A Feasibility Study
Authors: de Geus Christa J. C. , Huysmans Maaike A. , van Rijssen H. Jolanda , Juurlink Trees T. , de Maaker-Berkhof Marianne , Anema Johannes R.
Published: April 2023

Purpose

This feasibility study focusses on the implementation and use of a decision aid, which supports vocational rehabilitation (VR) professionals in helping clients with a disability pension return to work in practice. The decision aid shows an overview of the clients’ return to work barriers and suggests suitable VR interventions based on these barriers.

Methods

The study population consisted of VR professionals working at the Dutch Social Security Institute and their clients receiving a (partial) work disability pension. The feasibility was measured with concepts of the Linnan and Steckler framework and the attitude, social norm and self-efficacy model. Data were collected using questionnaires, checklists and qualitative interviews.

Results

Ten professionals participated in this study. Fifty-four clients were asked to fill in the questionnaire of the decision aid and 32 clients received VR care based on the decision aid. In general, VR professionals and clients were satisfied with the decision aid and perceived a few barriers for using the decision aid.

Conclusions

This study showed that it is feasible to implement and use the decision aid. To improve the implementation of this decision aid, it should be implemented in digital systems used by professionals to improve efficiency of working with the decision aid.
Makerspaces Fostering Creativity: A Systematic Literature Review
Authors: Soomro Sohail Ahmed , Casakin Hernan , Nanjappan Vijayakumar , Georgiev Georgi V.
Published: April 2023

Makerspaces are gaining popularity in the educational activities of all age groups, from primary schools to higher education institutions, particularly in science, technology, engineering, and mathematics (STEM) disciplines. Due to makerspaces’ hands-on learning approach, it is generally believed that learning in makerspaces influences students’ creative and thinking skills. Experiments have been performed to explore this relationship; however, they are limited to a particular type of makerspace and address only some aspects of creativity. Therefore, using a systematic literature review (SLR) approach, we attempted to understand the relationship between makerspaces and creativity in the context of STEM education. The SLR offers a holistic view of makerspaces fostering four aspects of creativity from primary to higher education. This SLR used three primary categories of terms in its search string: (i) makerspace and associated terms, (ii) creativity and innovation, and (iii) variants of the term “STEM.” Using the Summon meta-database, we searched 103 digital databases (including Scopus, IEEE, and ASEE). The initial search considered peer-reviewed scholarly journal articles and conference proceedings focusing on STEM disciplines published from 2000 to August 2021. After following the PRISMA guidelines for reporting systematic reviews, 34 relevant papers remained eligible for inclusion. The selected papers were analyzed using thematic analysis. Various types of makerspaces show empirical evidence of fostering creativity. This review additionally identifies seven factors that foster creativity in a makerspace environment. These findings will be beneficial for applying makerspace tools and interventions to enhance creativity in the context of STEM disciplines.
Pathfollowing for parametric mathematical programs with complementarity constraints
Authors: Kungurtsev Vyacheslav , Jäschke Johannes
Published: April 2023

In this paper we study procedures for pathfollowing parametric mathematical programs with complementarity constraints. We present two algorithms, one based on the penalty approach for solving standalone MPCCs, and one based on tracing active set bifurcations arising from doubly-active complementarity constraints. We demonstrate the performance of these two approaches on a variety of examples with different types of stationary points and also a simple engineering problem with phase changes.
The COVID-19 pandemic and family business performance
Authors: Miroshnychenko Ivan , Vocalelli Giorgio , De Massis Alfredo , Grassi Stefano , Ravazzolo Francesco
Published: April 2023

This study examines the impact of the COVID-19 pandemic on corporate financial performance using a unique, cross-country, and longitudinal sample of 3350 listed firms worldwide. We find that the financial performance of family firms has been significantly higher than that of nonfamily firms during the COVID-19 pandemic, accounting for pre-pandemic business conditions. This effect is pertinent to firms with strong family involvement in management or in both management and ownership. We also identify the role of firm-, industry-, and country-level contingencies for family business financial performance during the COVID-19 pandemic. This study offers a novel understanding of the financial resilience across different types of family business and sets an agenda for future research on the drivers of resilience of family firms to adverse events. It also provides important and novel evidence for policymakers, particularly for firms with different ownership and management structures.
A Systemic Perspective on Organizations: International Experience with the Systemic Constellation Method
Authors: Scholtens Salome , Boer Hedwig , Kiltz Lisa , Fleer Joke
Published: April 2023

A systemic perspective is considered helpful when facing complex organizational challenges, but its practical implementation may be challenging. A potential effective method that facilitates the practical application of a systemic perspective may be the Systemic Constellation method. This method aims to raise individuals’ awareness of their social context and to render explicit their tacit knowledge relating to this social context. In recent decades, consultants, coaches, and other professionals, worldwide, have adopted this method, acquired through self-education. However, thus far, this method received only little attention from the scientific community and scientific evidence on the effectiveness of the method is limited. There is currently almost no data on professionals using the Systemic Constellation method within organizations or on how and when they apply it. This lack of insights impedes its scientific evaluation and quality monitoring. We collected data from 273 professionals who use this method. Our results confirmed the existence of a diverse and growing international community. Respondents reported that the primary advantage of using this method is its perceived effectiveness. They felt that the method could benefit from a stronger scientific foundation. Our results shed light on a potentially effective and feasible method for applying a systemic perspective within organizations and suggest directions for future research.
Influences of adjacent suburbia, fire regimes and vegetation on the mammals of a peri-urban reserve
Authors: Kirkpatrick Jamie B. , Driessen Michael M. , Jarman Peter J. , Jakob Lauren
Published: April 2023

Urban development is thought to negatively affect most native mammals. Here we assess whether adjacent suburbia, fire regime and vegetation influence the activity of mammal species in a reserve in Hobart, Tasmania, Australia. We used multiple regression to analyse the relationship between distance from houses, fire history, vegetation structure and floristics, and mammal activity, derived from camera visits and signs. Animal diggings and visits by long-nosed potoroos, southern brown bandicoots and cats were greater close to houses, while visits by red-necked wallabies, rufous-bellied pademelons, brushtail possums and short-beaked echidnas were not. The structure of the vegetation, particularly related to shelter, was important in many models. Many models also included floristic ordination axes that reflected drainage, fire regime and distance from high-density housing. Positive relationships between the introduced predatory cat and some of its potential native prey animals may reflect the influences of close proximity to suburbia, such as elevated domestic mesopredator populations, and elevated resource availability in domestic gardens. Our results suggest that urban areas can have a valuable role in nature conservation, despite, or because of, their effects on remnant native ecosystems.
Bioaugmentation potential of inoculum derived from anaerobic digestion feedstock for enhanced methane production using water hyacinth
Authors: Obi Linda U. , Roopnarain Ashira , Tekere Memory , Adeleke Rasheed A.
Published: April 2023

The utilisation of water hyacinth for production of biogas is considered to be a solution to both its control and the global renewable energy challenge. In this instance, an investigation was conducted to evaluate the potential of water hyacinth inoculum to enhance methane production during anaerobic digestion (AD). Chopped whole water hyacinth (10% (w/v)) was digested to prepare an inoculum consisting mainly of water hyacinth indigenous microbes. The inoculum was incorporated in the AD of freshly chopped whole water hyacinth to set up different ratios of water hyacinth inoculum and water hyacinth mixture with appropriate controls. The results of batch tests with water hyacinth inoculum showed a maximal cumulative volume of 211.67 ml of methane after 29 days of AD as opposed to 88.6 ml of methane generated from the control treatment without inoculum. In addition to improving methane production, inclusion of water hyacinth inoculum reduced the electrical conductivity (EC) values of the resultant digestate, and, amplification of nifH and phoD genes in the digestate accentuates it as a potential soil ameliorant. This study provides an insight into the potential of water hyacinth inoculum to enhance methane production and contribute to the feasibility of the digestate as a soil fertility enhancer.
Secure Key Management and Mutual Authentication Protocol for Wireless Sensor Network by Linking Edge Devices using Hybrid Approach
Authors: Sharmila  , Kumar Pramod , Bhushan Shashi , Kumar Manoj , Alazab Mamoun
Published: April 2023

Wireless Sensor Networks (WSNs) play a crucial role in developing the Internet of Things (IoT) by collecting data from hostile environments like military and civil domains with limited resources. IoT devices need edge devices to perform real-time processing without compromising the security with the help of key management and authentication schemes. The above applications are prone to eavesdropper due to cryptographic algorithms' weaknesses for providing security in WSNs. The security protocols for WSNs are different from the traditional networks because of the limited resource of sensor nodes. Existing key management schemes require large key sizes to provide high-security levels, increasing the computational and communication cost for key establishment. This paper proposes a Hybrid Key Management Scheme for WSNs linking edge devices which use Elliptic Curve Cryptography (ECC) and a hash function to generate key pre-distribution keys. The Key establishment is carried out by merely broadcasting the node identity. The main reason for incorporating a hybrid approach in the key pre-distribution method is to achieve mutual authentication between the sensor nodes during the establishment phase. The proposed method reduces computational complexity with greater security and the proposed scheme can be competently applied into resource constraint sensor nodes.
Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging
Authors: Tang Bowen , Li Xia , Wang Yunzhang , Sjölander Arvid , Johnell Kristina , Thambisetty Madhav , Ferrucci Luigi , Reynolds Chandra A. , Finkel Deborah , Jylhävä Juulia , Pedersen Nancy L. , Hägg Sara
Published: April 2023

Aging is a major risk factor for many chronic diseases. This study aimed to examine the effects of antihypertensive, lipid-lowering, and antidiabetic drugs on biological aging. We included 672 participants and 2746 repeated measurements from the Swedish Adoption/Twin Study of Aging. Self-reported medicine uses were categorized into antidiabetic, antihypertensive, and lipid-lowering drugs. A total of 12 biomarkers for biological aging (BA biomarkers) were included as outcomes. Conditional generalized estimating equations were applied conditioning on individuals to estimate the drug effect on BA biomarker level within the same person when using or not using the drug. Chronological age, body mass index, smoking status, number of multiple medication uses, blood pressure, blood glucose level, and apoB/apoA ratio were adjusted for as covariates in the model. Overall, using antihypertensive drugs was associated with a decrease in one DNA-methylation age (PCGrimAge: beta = − 0.39, 95%CI = − 0.67 to − 0.12). When looking into drug subcategories, calcium channel blockers (CCBs) were associated with a decrease in several DNA-methylation ages (PCHorvathAge beta = − 1.28, 95%CI = − 2.34 to − 0.21; PCSkin&bloodAge beta = − 1.34, 95%CI = − 2.61 to − 0.07; PCPhenoAge beta = − 1.74, 95%CI = − 2.58 to − 0.89; PCGrimAge beta = − 0.57, 95%CI = − 0.96 to − 0.17) and in functional biological ages (functional age index beta = − 2.18, 95%CI = − 3.65 to − 0.71; frailty index beta = − 1.31, 95%CI = − 2.43 to − 0.18). However, the results within other drug subcategories were inconsistent. Calcium channel blockers may decrease biological aging captured by the BA biomarkers measured at epigenetic and functional level. Future studies are warranted to confirm these effects and understand the underlying biological mechanisms.
Quasi-Newton Methods for Partitioned Simulation of Fluid–Structure Interaction Reviewed in the Generalized Broyden Framework
Authors: Delaissé Nicolas , Demeester Toon , Haelterman Rob , Degroote Joris
Published: April 2023

Fluid–structure interaction simulations can be performed in a partitioned way, by coupling a flow solver with a structural solver. However, Gauss–Seidel iterations between these solvers without additional stabilization efforts will converge slowly or not at all under common conditions such as an incompressible fluid and a high added mass. Quasi-Newton methods can then stabilize and accelerate the coupling iterations, while still using the solvers as black boxes and only accessing data at the fluid–structure interface. In this review, the IQN-ILS, IQN-MVJ, IBQN-LS, MVQN, IQN-IMVLS and IQN-ILSM methods are reformulated in the generalized Broyden framework to illustrate their similarities and differences. Also related coupling techniques are reviewed and a performance comparison is provided where available.
Screening of Lactic Acid Bacteria Strains to Improve the Properties of Non-fat Set Yogurt by in situ EPS Production
Authors: Ramos Inés María , Seseña Susana , Poveda Justa María , Palop María Llanos
Published: April 2023

Some lactic acid bacteria (LAB) are capable of producing exopolysaccharides (EPS), which can be used in the dairy industry to reduce syneresis and improve the viscosity and texture of fermented products. The aim of the present study was to screen the EPS-producing capacity of 123 LAB strains isolated from fermented foods to search for those able to produce EPS with the optimal technological aptitude to be applied in non-fat set yogurt manufacture. They were grown on MRS-sucrose and assigned to ropy or mucoid phenotype depending on the appearance of the colonies. Twenty-five of them were selected and assayed for production of both cell-bound EPS (EPS-b) and EPS released to the medium (EPS-r). Those resulting in the most EPS producers (Levilactobacillus brevis UCLM-Lb47, Leuconostoc mesenteroides subsp. mesenteroides 6F6-12 and Leuconostoc mesenteroides subsp. mesenteroides 2F6-9) were used to manufacture non-fat set yogurts. These yogurts were analyzed for microbiological and physicochemical properties (pH, titratable acidity, total solids), water-holding capacity, apparent viscosity, and sensory characteristics during a 28-day cold storage period. The yogurts made with the selected strains showed higher values of water-holding capacity, EPS concentration, and viscosity in the mouth than the control yogurt, which presented a more fluid texture. The results obtained suggest that the three selected strains could be used to replace hydrocolloids in non-fat set yogurt formulation, obtaining a clean-label product that would improve consumer acceptance.

Graphical Abstract
A Method for In-Vivo Mapping of Axonal Diameter Distributions in the Human Brain Using Diffusion-Based Axonal Spectrum Imaging (AxSI)
Authors: Gast Hila , Horowitz Assaf , Krupnik Ronnie , Barazany Daniel , Lifshits Shlomi , Ben-Amitay Shani , Assaf Yaniv
Published: April 2023

In this paper we demonstrate a generalized and simplified pipeline called axonal spectrum imaging (AxSI) for in-vivo estimation of axonal characteristics in the human brain. Whole-brain estimation of the axon diameter, in-vivo and non-invasively, across all fiber systems will allow exploring uncharted aspects of brain structure and function relations with emphasis on connectivity and connectome analysis. While axon diameter mapping is important in and of itself, its correlation with conduction velocity will allow, for the first time, the explorations of information transfer mechanisms within the brain. We demonstrate various well-known aspects of axonal morphometry (e.g., the corpus callosum axon diameter variation) as well as other aspects that are less explored (e.g., axon diameter-based separation of the superior longitudinal fasciculus into segments). Moreover, we have created an MNI based mean axon diameter map over the entire brain for a large cohort of subjects providing the reference basis for future studies exploring relation between axon properties, its connectome representation, and other functional and behavioral aspects of the brain.
Efficacy of Pembrolizumab Monotherapy in Japanese Patients with Advanced Gastric or Gastroesophageal Junction Cancer
Authors: Muro Kei , Shitara Kohei , Yamaguchi Kensei , Yoshikawa Takaki , Satake Hironaga , Hara Hiroki , Sugimoto Naotoshi , Machida Nozomu , Goto Masahiro , Kawakami Hisato , Amagai Kenji , Omuro Yasushi , Esaki Taito , Hironaka Shuichi , Nishina Tomohiro , Komatsu Yoshito , Matsubara Hisahiro , Shiratori Shinichi , Han Shirong , Satoh Taroh , Ohtsu Atsushi
Published: April 2023

Purpose

Pembrolizumab demonstrated antitumor activity in programmed death ligand 1 positive (combined positive score (CPS) ≥ 1) gastric/gastroesophageal junction cancer in KEYNOTE-059 (third line or beyond), KEYNOTE-061 (second line), and KEYNOTE-062 (first line). We characterized efficacy and safety of pembrolizumab monotherapy in Japanese patients across several lines of therapy in these studies.

Methods

This analysis was conducted in 34 patients from KEYNOTE-059 cohort 1 (all pembrolizumab), including 13 patients with CPS ≥ 1, 65 patients with CPS ≥ 1 from KEYNOTE-061 (pembrolizumab, n = 27; chemotherapy, n = 38), and 70 patients with CPS ≥ 1 from KEYNOTE-062 (pembrolizumab, n = 38; chemotherapy, n = 32). Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and safety were evaluated.

Results

In KEYNOTE-059, ORR with pembrolizumab was 9%, median PFS was 2 months, and median OS was 10 months. In KEYNOTE-061, median OS was 12 months with pembrolizumab versus 10 months with chemotherapy (hazard ratio (HR), 0.67; 95% confidence interval (CI), 0.39–1.15). Median PFS (pembrolizumab vs. chemotherapy) was 2 months versus 4 months (HR, 1.21; 95% CI, 0.69–2.13); ORR was 7% versus 18%. In KEYNOTE-062, median OS was 20 months with pembrolizumab versus 18 months with chemotherapy (HR, 0.76; 95% CI, 0.43–1.33). Median PFS (pembrolizumab vs. chemotherapy) was 6 months versus 7 months (HR, 1.03; 95% CI, 0.61–1.74); ORR was 29% versus 34%.

Conclusions

The current analysis provides valuable information that anti–PD-1 therapies are worthy of further assessment for gastric cancer.

Trial Registration

ClinicalTrials.gov: NCT02335411 (KEYNOTE-059), NCT02370498 (KEYNOTE-061), and NCT02494583 (KEYNOTE-062).