bluuebunny/crossref_metadata_2025 huggingface dataset:
No obvious advantage of hyperthermic intraperitoneal chemotherapy after interval debulking surgery in the treatment of advanced ovarian cancer: A retrospective study
Authors: Lyu Mengmeng , Lu Jin , Shen Yang , Chen Qianqian , Deng Fei , Wang Jinhua
Published: September 2022

Objective

To study the efficacy of interval debulking surgery (IDS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) compared to IDS alone for the treatment of ovarian cancer after neoadjuvant chemotherapy (NACT).

Methods

We conducted a retrospective study of patients with stage IIIC/IV high-grade serous ovarian carcinoma who underwent surgery at our center from January 2018 to December 2019. Patients who underwent IDS after NACT with (N = 20) or without (N = 42) HIPEC were included. HIPEC was administered after surgery and was combined with 1–2 courses of intraperitoneal hyperthermic perfusion with normal saline only. We analyzed clinical information and outcomes for the two groups.

Results

The median progression-free survival (PFS) was 14.05 months in the IDS plus HIPEC group and 12.97 months in the IDS group (P = 0.597). The median overall survival (OS) was not reached. After adjustment for age between the two groups, the differences in PFS and OS remained nonsignificant. The change ratio of postoperative CA-125 to preoperative CA-125 was 0.66 in the IDS plus HIPEC group and 0.53 in the IDS group (P = 0.341). The difference in human epididymis protein 4 (HE-4) change ratio between the two groups was nonsignificant (P = 0.225). No significant difference was observed in the occurrence of grade 3 and 4 adverse events between the two groups (P = 0.201).

Conclusion

After NACT, IDS plus HIPEC did not show significant PFS and tumor index change ratio benefits over IDS alone in patients with primary ovarian cancer. Further investigations are needed to assess the role of HIPEC in the treatment of ovarian cancer.
Fortification of diets with omega-3 long-chain polyunsaturated fatty acids enhances feedlot performance, intramuscular fat content, fat melting point, and carcass characteristics of Tattykeel Australian White MARGRA lambs
Authors: Pewan Shedrach Benjamin , Otto John Roger , Kinobe Robert Tumwesigye , Adegboye Oyelola Abdulwasiu , Malau-Aduli Aduli Enoch Othniel
Published: September 2022

Meat eating quality indices such as intramuscular fat content (IMF) and fat melting point (FMP) of the Longissimus thoracis et lumborum muscle and the feedlot performance, carcass traits, and commercial wholesale cuts of lot-fed Tattykeel Australian White (TAW) MARGRA lambs as a result of dietary fortification of the diet with omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) were evaluated. A total of 75 TAW MARGRA lambs at 6 months of age with an average liveweight of 30 ± 1.2 kg were used. The lambs were randomly allocated to the following three dietary treatments of 25 lambs each in a 47-day feeding trial using a completely randomized experimental design: (1) control diet of hay plus pellets without omega-3 oil, (2) hay plus commercial whole grain pellets (MSM) without omega-3 oil, and (3) hay plus pellets fortified with omega-3 oil. It was hypothesized that dietary supplementation with omega-3 fortified pellets will improve feedlot performance, meat-eating quality indices of IMF, FMP, and carcass characteristics. Lot-fed lambs on the MSM whole grain had the highest feed intake of 1.69 kg/day, followed by the control at 1.57 kg/day and the lowest in the omega-3 diet at 1.01 kg/day (p = 0.0001). However, the omega-3 diet had the highest average daily gain of 230 g/head/day (p = 0.0001), indicating the greatest feed efficiency since it had the best growth response with minimal feed intake. Post-slaughter evaluation of the Longissimus thoracis et lumborum muscle revealed significant treatment variations in IMF (p = 0.0001), FMP (p = 0.0001), pH (p = 0.0380), and wholesale French rack primal cut (p = 0.0001). Strong correlations (p < 0.05) between liveweight, temperature, pH, FMP, and IMF were observed. Similarly, significant correlations between carcass characteristics of total saleable meat yield, lean trim, fat trims, bones, and leg shank were evident (p < 0.05). However, there were no treatment differences in the final liveweight, GR fat depth, hot standard carcass weight, or dressing percentage. The findings indicate that feedlot performance, meat-eating quality traits such as IMF and FMP, and commercial wholesale French rack cuts can be further improved during feedlot finishing of TAW MARGRA lambs through dietary supplementation with omega-3 oils, and hence the tested hypothesis of improved meat quality attributes is partially confirmed.
Cranial thoracic myelopathies (T1-T6 vertebrae): Retrospective evaluation of the signalment, clinical presentation, and, presumptive or final diagnoses in 84 dogs
Authors: Lopes Bruno A. , Ives Edward J. , José-López Roberto , Gutierrez-Quintana Rodrigo , Abouzeid Jad , Freeman Paul , Redondo José Ignacio , Sánchez-Masián Daniel
Published: September 2022

The aim of the study was to describe the signalment, clinical presentation and presumptive or final diagnoses of dogs with cranial thoracic spinal cord lesions identified on advanced imaging. Retrospective evaluation of the databases of three veterinary specialty centres, between 2009 and 2021, was performed to identify dogs with a lesion affecting the cranial thoracic vertebral column (T1-T6 vertebrae) as the primary cause for presenting signs of myelopathy and/or spinal pain. Eighty-four dogs were included in the study, with the majority (n = 76) presenting with a progressive history of over 4-weeks' duration. On neurologic examination, most dogs were ambulatory (n = 64), and the most common neuroanatomic localisation was the T3-L3 spinal cord segments (n = 63). Twelve dogs (14%) showed a short-strided thoracic limb gait on clinical examination. The most common diagnosis was neoplasia (n = 33), followed by anomalies (n = 22, including vertebral body malformations in 14 dogs) and degenerative disorders (n = 16, with intervertebral disc protrusion diagnosed in 9 dogs). The most common vertebrae affected were T3 and T5. Most dogs with degenerative conditions showed asymmetric clinical signs, and the majority of dogs with neoplasia showed signs of spinal hyperaesthesia on examination. The findings of this study describe the clinical signs and presumptive or final diagnoses associated with lesions affecting the cranial thoracic spinal cord. When combined with the signalment and clinical history, this information can assist in both the recognition of and problem-based approach to these cases.
Early life environment affects behavior, welfare, gut microbiome composition, and diversity in broiler chickens
Authors: de Jong Ingrid C. , Schokker Dirkjan , Gunnink Henk , van Wijhe Maudia , Rebel Johanna M. J.
Published: September 2022

This study aimed to identify whether early-life conditions in broiler chickens could affect their behavior and welfare, and whether or not this was associated with an altered gut microbiome composition or diversity. Broilers were tested in a 2 x 2 factorial design with hatching conditions [home pen (OH) or at the hatchery (HH)] and enrichment (dark brooder (EE) or no brooder (NE) until 14 days of age) as factors (N= 6 per treatment combination). Microbiota composition was measured in the jejunum on days (d) 7, 14, and 35 and in pooled fecal samples on day 14. A novel environment test (NET) was performed on days 1 and 11, and the behavior was observed on days 6, 13, and 33. On day 35, composite asymmetry was determined and footpad dermatitis and hock burn were scored. In their home pen, HH showed more locomotion than OH (P= 0.05), and NE were sitting more and showed more comfort behavior than EE at all ages (P<0.001 andP= 0.001, respectively). On days 6 and 13 NE showed more eating and litter pecking while sitting, but on day 33 the opposite was found (age*enrichment:P= 0.05 andP<0.01, respectively). On days 1 and 11, HH showed more social reinstatement in the NET than OH, and EE showed more social reinstatement than NE (P<0.05). Composite asymmetry scores were lower for EE than NE (P<0.05). EE also had less footpad dermatitis and hock burn than NE (P<0.001). Within OH, NE had a more diverse fecal and jejunal microbiome compared to EE on day 14 (feces: observed richness:P= 0.052; jejunum: observed richness and Shannon:P<0.05); the principal component analysis (PCA) showed differences between NE and EE within both HH and OH in fecal samples on day 14, as well as significant differences in bacterial genera such asLactobacillusandLachnospiraceae(P<0.05). On day 35, PCA in jejunal samples only showed a trend (P= 0.068) for differences between NE vs. EE within the OH. In conclusion, these results suggest that especially the dark brooder affected the behavior and had a positive effect on welfare as well as affected the composition and diversity of the microbiome. Whether or not the behavior was modulated by the microbiome or vice versa remains to be investigated.
Hospital discharge planning: a qualitative study of new-graduate physiotherapists' experiences
Authors: Martin Romany , Phan Andrew , Tan Shaun , Mandrusiak Allison , Forbes Roma
Published: September 2022

Purpose: Discharge planning constitutes a large part of a physiotherapist's role when working in hospital settings. The challenges of decision-making relating to discharge planning have been identified by experienced physiotherapists. Despite known challenges associated with the transition from student to clinician, the experiences of new-graduates undertaking discharge planning are largely unknown. Therefore, this study aimed to explore:1)    new-graduate physiotherapists' experiences of discharge planning in hospital settings, and2)    the influence of pre-professional training on their perceived preparedness for discharge planning.Design: A qualitative general inductive approach using semi-structured interviews. New-graduate physiotherapists (n = 14) working in hospital settings were recruited.Finding: Four themes were generated: 1) responding to the pressures associated with discharging patients, 2) complex decision-making, 3) the role of the interprofessional team, and 4) desiring additional context and complexity from pre-professional training.Practice Implications: The study has identified that new-graduates underestimate the extent to which discharge planning features in their roles within hospital settings, and are unaware of the interprofessional practice required. Whilst they felt that their pre-professional training provides the technical skills required for their roles, they felt that they were not prepared for their role within the broader healthcare system, nor the complexity of clinical practice. This study encourages education providers to emphasise the role of physiotherapists within the broader health care system, through highlighting contexts where physiotherapy knowledge can be applied (i.e., discharge planning) and understanding the role of the physiotherapist within the interprofessional team.Limitations: Important perspectives of mentors and other members of the interprofessional team involved in discharge planning have not been included in this study which may have impacted the interpretation of the results.
Katarzyna Maksymiuk, Geography of Roman-Iranian wars. Military operations of Rome and Sasanian Iran, Siedlce 2015, SS 143; ISBN 978-83-6244-713-8
Authors: KETTENHOFEN Erich
Published: September 2022

Book Review
Czesław Jeśman, Communicable diseases in the Polish Army in the years 1918-1939 as a prophylactic and therapeutic issue, Łódź 1997 (2009)
Authors: KOWALCZYK Tomasz
Published: September 2022

Book Review
Neural Network and Back Propagation
Authors: Agarwal Nikunj
Published: September 2022

Humans and computers are suited to different types of tasks. Like, finding the sine of any number is difficult for humans, but easy for the computers. On the other hand, looking and identifying the image of a bird is very easy for us, as compared to the machines [1]. But nowadays, Artificial neural networks or ANNs are most commonly used in image processing. In fact, the recent deep learning algorithms have surpassed the human ability of image recognition. It is proved and stated that BPNN (Backpropagation Neural Networks) have a very high accuracy. A large part of recent success of neural network is explained on the basis of very high data availability. Thus, in B-P the network is trained with a lot of training examples so that it doesn’t compromise with the efficiency of the system. By the end of this century, it is expected that computers will be training neural networks with as many neurons as the human brain has [1][2]. Although it is difficult to predict what the true abilities of artificial intelligence will be by then, our experience with computer vision should prepare us to expect something unexpected. So, with this attempt paper tries to give the idea of how image is recognized and how back propagation works.
Paratuberculosis bovina: Efecto de las micobacterias ambientales en el diagnóstico serológico
Authors:   , Di Paolo Leandro Adrián
Published: September 2022

Esta tesis pretende ser un aporte para el diagnóstico serológico de la paratuberculosis bovina a través del desarrollo y puesta a punto de una técnica de ELISA indirecto con el agregado de urea (ELISA-u) como agente caotrópico mejorador de la especificidad. Además, se realizó el aislamiento e identificación de micobacterias ambientales (MA) a partir de materia fecal y se probó el ELISA con sueros inmunoabsorbidos con MA mayormente identificadas. Se trabajó sobre tres rodeos con infección endémica y sobre muestras de suero ingresadas al servicio de diagnóstico del CEDIVE. Se procesaron más de 2000 muestras con ELISA-u. Además, se obtuvo el índice urea (IU), el cuál mejora la interpretación de los resultados. El ELISAu tuvo una sensibilidad del 52% y una especificidad del 91%. Con estadística Bayesiana se calculó un VPP de 62%, un VPN de 90%, un LR+ de 6 y el LR- de 0,46. La prueba de ROC determinó un AUC de 0.86 y de 0.90 para ELISA-u e IU respectivamente, sin que existan diferencias significativas (p= 0.13) entre pruebas. El odds ratio calculado para IU demostró que los individuos que presentan un IU por encima del 80 (expuestos) tienen 28 más probabilidades de tener PTBC, considerándose un fuerte factor de riesgo para el rodeo donde se encuentran esos individuos. La presencia de MA en la materia fecal mostró asociación estadística significativa con la positividad al ELISA-u (p=<0.00), siendo M. nonchromogenicum la cepa mayormente aislada; mientras que el uso de la urea como mejorador de la especificidad presentó diferencias estadísticas significativas comparado con la utilización de sueros inmunoabsorbidos con M. phlei y M. nonchromogenicum. Tanto el ELISA-u como el IU mostraron características operativas y predictivas más que alentadoras para la detección de animales con paratuberculosis, principalmente en mayores de 2 años.
DESIGN AND EXPERIMENT OF STEPLESS ADJUSTABLE SOWING AMOUNT HOLE-TYPE METERING WHEEL FOR RICE
Authors: CHEN Xiongfei , XIA Haiyang , LIU Jun’an , TU Tuanpeng , SUN Zeyu , YU Jiajia , LIU Muhua
Published: September 2022

The performance of hole-type metering device influenced the adaption of different rice varieties in the mechanical direct hill-drop seeding technology, and the stepless adjustable sowing amount hole-type metering wheel was designed to solve this problem. The mechanical characteristics of different seeds were analyzed to acquire the parameters including hole diameter, depth, number, diameter of metering wheel and jogger slider mechanism, and the performance of metering wheel was tested on JPS-12 experimental bench by using Yongyou 12, Huanghuazhan and Wanxiang youhuazhan varieties. The hole depth and rotating speeds of metering wheel were the independence variance, the average seed numbers per hole, the coefficient of variance and the cavity rate were taken as the evaluation indexes. The results showed that the metering wheel could sow 3.58~7.82 seeds per hole with less than 40% of the coefficient of variance in average seeds number per hole and less than 5% of the cavity rate, and the regression model of average seed numbers per hole was built by employing the length of seeds, the rotating speed of metering wheel and the hole depth. The correlation coefficient was 0.952, the prediction error of regression mode was 0.32~11.35% by the field experiment. This study could be used for designing the hole-type metering device for rice.
EXPERIMENTAL RESEARCH ON A FEED PELLETIZING EQUIPMENT DESIGNED FOR SMALL AND MEDIUM-SIZED FISH FARMS
Authors: NENCIU Florin , VOICEA Iulian , STEFAN Vasilica , NAE Gabriel , MATACHE Mihai , MILIAN Gabriela , ARSENOAIA Vlad-Nicolae
Published: September 2022

Due to the recent rise in the price of energy and grains, purchasing high-quality pelletized food has caused significant challenges for small and medium-sized fishing farms. The present article aims to assist breeders and farmers with limited financial resources in producing high quality feeder by providing in detail the design and performance of a wet pelletizing equipment. The proposed pelletizing technology demonstrated high efficiency in use, reduced operating expenses, and a high productivity. Four different feed mixes were processed with the pelleting equipment, functioning with a 5 mm die. The experiment results indicated a maximum processing rate of 100 kg/h at an average pelletizing efficiency of 91.5%. The total pelletizing capacity of 0.8 - 1 tons per day is sufficient to provide feed for a medium-sized fishing farm, reducing dependence on the feed market and allowing for a simple nutritional mix customization.
DESIGN OF DYNAMIC COMPENSATION SYSTEM FOR CORN SEEDING POSITION BASED ON FUZZY PID CONTROL AND ANALYSIS OF BENCH TEST
Authors: CHEN Kaikang , YUAN Yanwei , ZHAO Bo , ZHOU Liming , NIU Kang , DONG Xin , JIN Xin , ZHENG Yongjun
Published: September 2022

Aiming at the problem that the existing planters cannot accurately maintain the seeding spacing and row spacing in the field, the high-speed photography technology is used to analyze the seeding trajectory, so as to determine the key factors affecting the seeding position. First, a dynamic compensation system for maize seeding position based on fuzzy PID control was designed. In the dynamic compensation system, the biaxial angle sensor was used to detect the angle of seeding monomer, and the space rotation theory was used to calculate the offset of the seeding position. Then, the dynamic compensation of seeding position was completed by the fuzzy PID control servo electric push rod, and the response time of fuzzy PID control system was 0.035 s. When the seed spacing of maize was 30 cm, the conveyor speed was 1.67 m/s and the seed tray speed was 30 r/min. Finally, the bench test was carried out under the conditions of random disturbance signal, sinusoidal wave disturbance signal and random disturbance signal plus sinusoidal wave disturbance signal. The results showed that compared without dynamic compensation, the variation coefficient of the longitudinal grain spacing and the transverse grain spacing decreased by an average of 6.94 % and 9.16 %, respectively. In this way, this study can provide a reference for improving the stability of seeding row spacing and plant spacing.
MECHANISED HARVESTING OF INFLORESCENCES OF MEDICINAL AND AROMATIC PLANT SPECIES CULTIVATED ON A SMALL SCALE
Authors: MUSCALU Adriana , TUDORA Cătălina , SORICĂ Cristian , MÎRZAN Oana , NAIE Margareta , BARCANU-TUDOR Elena
Published: September 2022

The quality of plant material obtained from cultivated medicinal and aromatic plants depends on several important factors, including harvesting, which must be carried out according to the requirements of each cultivation technology. Current producers, especially those who grow these species on small and medium-sized areas, face the high price of labour or its acute shortage, as well as limited access to specialized equipment. The paper provides a brief summary of current concerns about mechanised harvesting of inflorescences of medicinal species cultivated on a small-scale, with mechanisation generally being a guarantee of economic efficiency and quality.
DESIGN AND EXPERIMENT OF TELESCOPIC ROD TOOTH-RIBBED ROD ROLLER TYPE BUCKWHEAT THRESHING DEVICE
Authors: WANG Jiawei , WANG Xiaoguo , YU Xiaohong , ZHENG Decong , LI Zhiwei , SONG Haiyan
Published: September 2022

Aiming at the problems of high moisture content of stems during buckwheat harvesting and easy clogging of grid concave plates, a telescopic rod tooth-ribbed rod roller type threshing device was designed. The device is mainly composed of a ribbed rod roller and telescopic rod teeth. When the ribbed rod roller type rotates, the telescopic rod teeth do reciprocating telescopic motion. When the rod teeth rotate to the minimum threshing gap, the outstretch length is the smallest. When the rod teeth rotate to the top, the outstretch length maximum. The device solves the problems of poor material flow between threshing devices and clogging of grid concave plates. This threshing device was attached to the threshing performance test bench, and the buckwheat threshing test was performed. Through the single factor test, the threshing parameter range under the condition of low loss rate and damage rate of the threshing device was obtained: the speed of the threshing roller is 350~450 r/min, the feeding amount is 0.8~1.2 kg/s, and the threshing gap is 9~11 mm. Through the quadratic orthogonal rotation combination test, the results were fitted by multiple linear regression, and the regression equations of the loss rate and the broken rate were obtained, and the significance test was carried out. The response surface analysis of the main influencing factors was carried out to explore the influence of threshing parameters on the loss rate and damage rate. Through parameter optimization, the threshing parameter combination with the lowest loss rate and damage rate of the threshing device was obtained. The speed of the threshing roller is 405.47 r/min, the feed amount is 1.06 kg/s, and the threshing gap is 10.49 mm. Under these conditions, the loss rate is 0.05%, and the damage rate is 4.05%. The overall performance of the threshing device is good, which provides a theoretical basis for the research and development of buckwheat mechanized harvesting equipment.
The influence of the police on vehicle speed in built-up areas
Authors: Dębiński Marcin , Bohatkiewicz Janusz
Published: September 2022

In many cases, the effects of road accidents have significant impact on human health. This translates directly into society, in both material and emotional terms. The severity of the injury in a road event depends largely on the speed of the vehicles. Excessive vehicle speed is of particular concern in incidents involving vulnerable road users. As confirmed by literature analysis and research, in most cases drivers do not respect the speed limits introduced by the road signs. Existing solutions allow to introduce permanent or temporary speed control. This paper investigates speeding and driver behaviour in built-up areas near schools and pedestriancrossings. The aim of the research described in the paper is to determine the influence of the effectiveness of police actions on speed reduction and improvement of road safety.
PENGARUH KONSTRUKSI SOSIAL BUDAYA TERHADAP KETERWAKILAN POLITIK PEREMPUAN DI PROVINSI JAMBI
Authors: Sutri Destemi Elsi  , Riri Maria Fatriani  , Rahman  , Maratun Saadah
Published: September 2022

This paper discusses the influence of socio-cultural construction on women's political representation in Jambi Province. Women continue to be underrepresented in the public sphere, particularly in politics. In three districts in Jambi Province, namely Merangin Regency, Kerinci Regency, and Sungai Penuh City, there is no representation of women in the 2019 election results. This study was carried out using a descriptive quantitative method, which began by mapping the indicators of socio-cultural construction. According to the findings, 225 people out of 300 respondents stated that they did not vote for female legislative candidates in the 2019 election due to the strong patriarchal culture in the three districts, as well as the lack of popularity of female candidates due to their lack of activity in public spaces thus far. Another factor is women's low participation in party membership; political careers are viewed as more appropriate to pursue if they begin as partisan party cadres.
Transitional Justice for Legacy of State Violence and Transformative Justice
Authors:   Korean Association of Victimology, Kim Hyekyung
Published: September 2022

With the revision of the "Basic Act on the Settlement of Past History for Truth and Reconciliation" in 2020, the legal basis for the activities of the 2nd Truth and Reconciliation Committee was established. And based on this, the committee began investigating 328 cases, including the Brotherhood Welfare Support Case, on May 27, 2021, and began activities to investigate the past truth.
Apart from the historical causality after liberation, it cannot be denied that Korea has also undergone a transitional history of state violence and infringement of basic rights due to military dictatorship and anti-communist ideology. In addition, in this regard, There have already been tried to shed light on our history, such as the May 18 Democratic Movement, forced mobilization of Japanese colonial era, and the liquidation of Korea-Japan history in Japanese colonial era, from the perspective of the transitional justice. Even before the introduction of the international standard of liquidation of the implementation period in Korea, such historical events had been mentioned under the name of past liquidation or fact-finding for the purpose of truth finding, restoring honor, or compensation.
The definition of transitional justice is not completely unified and although the concept is not consistent, it can be understood as the process of securing responsibility by the state or society in the process of transition to a free democratic society after massive human rights violations by state power or state violence.
In other words, it would be appropriate to understand the transitional justice as a means of realizing the transition in the process of pursuing the social ideal of freedom and democracy, not as a society that realizes complete purpose like the term 'transitional'. In other words, past liquidation through compensation and honor recovery is not the direction in which society should ultimately proceed, but is itself a transitional definition. The international community also sees the direction that society should pursue after liquidation in the past as a transformative justice, which means realizing or pursuing justice through systematic transformation not only in law but also in all fields of society.
Regarding the activities of the 2nd Truth Reconciliation Committee and the direction of the committee, there would be first looked at the concept and background of the transitional justice in the international community, and then examine the relationship between transitional justice and transformative justice to realize social transformation after past liquidation.
The Construction of Ergodic Maps with Prescribed Invariant Density and Power Spectrum Poles
Authors: McDonald Andre , van Wyk Anton
Published: September 2022

We propose an analytical method for constructing ergodic and piecewise linear hat maps with a piecewise constant invariant density selected to approximate a prescribed invariant density, and a rational power spectral density with an arbitrary number of prescribed nonrepeating poles. These semi-Markov maps permit a matrix representation of the Frobenius-Perron operator, referred to as the Frobenius-Perron matrix. We prove that the poles of a piecewise linear hat map's power spectral density coincide with the unique nonzero and nonunity (in absolute value) eigenvalues of the map's Frobenius-Perron matrix. A  hat map is constructed such that it possesses a Frobenius-Perron matrix with a selectable eigenspectrum, thereby allowing for the prescription of its poles. A topological conjugate of this map is subsequently constructed. The conjugate map's poles are equal to those of the original map, but its piecewise constant invariant density is selected to approximate the prescribed invariant density. Similar to previous methods, the novel method does not afford the opportunity to prescribe the zeros of the map's power spectral density. However, unlike these methods, all of the poles are prescribable and no numerical search is performed during construction. We characterize several piecewise linear hat maps constructed using the novel method.
PENGARUH CAPITAL ADEQUACY RATIO, NET INTEREST MARGIN, DAN LOAN TO DEPOSIT RATIO TERHADAP RETURN ON ASSETS PADA PT. BANK BNI (PERSERO), TBK.
Authors: Moorcy Nadi Hernadi
Published: September 2022

“Pengaruh Capital Adequacy Ratio (CAR), Net Interest Margin (NIM), dan Loan to Deposit Ratio Terhadap Return On Assets (ROA) pada PT. Bank BNI (Persero), Tbk.”. Tujuan penelitian ini adalah untuk mengetahui pengaruh CAR, NIM, dan LDR terhadap ROA pada PT. Bank BNI (Persero), Tbk. Populasi yang digunakan dalam penelitian ini adalah semua Laporan Keuangan PT. Bank BNI (Persero), Tbk. dengan menggunakan teknik purposive sampling dengan kriteria yang ditetapkan penulis. Analisis yang digunakan adalah metode analisis regresi linier berganda. Berdasarkan hasil pengujian secara simultan diperoleh bahwa variabel CAR, NIM, dan LDR secara simultan mempunyai pengaruh yang signifikan terhadap ROA pada PT. Bank BNI (Persero), Tbk., sedangkan secara parsial variabel CAR mempunyai pengaruh negatif dan signifikan sekaligus dominan terhadap ROA pada PT. Bank BNI (Persero), Tbk., NIM mempunyai pengaruh positif dan tidak signifikan terhadap ROA pada PT. Bank BNI (Persero), Tbk., dan LDR mempunyai pengaruh negatif dan tidak signifikan terhadap ROA pada PT. Bank BNI (Persero), Tbk.
PENGARUH PROMOSI DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN PADA PT. SIMPATIK CABANG UNAAHA KABUPATEN KONAWE
Authors: Melati Melati
Published: September 2022

Penelitian ini bertujuan untuk mengetahui dan menjelaskan Pengaruh Promosi dan Kualitas Produk Terhadap Keputusan Pembelian Pada PT. Simpatik Cabang Unaaha Kabupaten Konawe. Populasi dalam penelitian ini adalah Populasi dalam penelitian ini adalah sebagian konsumen PT. Simpatik Cabang Unaaha periode Januari s/d Desember 2015 yang berjumlah 482 Orang. Penelitian ini menggunakan analisis regresi linear berganda.

 

Hasil penelitian menunjukkan bahwa: Secara simultan terdapat pengaruh yang signifikan variabel promosi dan kualitas produk terhadap keputusan pembelian. Fakta ini menunjukkan bahwa semakin baik promosi dan kualitas produk maka semakin tinggi pula keputusan pembelian pada PT.Simpatik Cabang Unaaha.Variabel promosi berpengaruh signifikan terhadap keputusan pembelian. Semakin baik promosi yang diberikan maka semakin tinggi pula keputusan pembelian pada PT.Simpatik Cabang Unaaha. Fakta ini menunjukkan bahwa semakin baik citra merek yang diberikan memiliki kontribusi dalam peningkatan keputusan pembelian.Variabel kualitas produk berpengaruh signifikan terhadap keputusan pembelian. Semakin baik kualitas produk yang diberikan maka semakin tinggi pula keputusan pembelian pada PT.Simpatik Cabang Unaaha. Fakta ini menunjukkan bahwa semakin baik kualitas produk yang diberikan memiliki kontribusi dalam peningkatan keputusan pembelian.
PENGARUH INFLASI, SUKU BUNGA, DAN NILAI TUKAR TERHADAP INDEKS HARGA SAHAM GABUNGAN DI BURSA EFEK INDONESIA
Authors: Hernadi Moorcy Nadi , Alwi Mahfud , Yusuf Tamzil
Published: September 2022

Pengaruh Inflasi, Suku Bunga, dan Nilai Tukar Terhadap Indeks Harga Saham Gabungan Di Bursa Efek Indonesia. Tujuan penelitian ini adalah Penelitian ini bertujuan untuk mengetahui pengaruh Inflasi, Suku Bunga dan Nilai Tukar terhadap Indeks Harga Saham Gabungan di Bursa Efek Indonesia.. Populasi yang digunakan dalam penelitian ini adalah sebanyak 718 perusahaan, dengan menggunakan teknik purposive sampling dengan kriteria yang ditetapkan penulis. Analisis yang digunakan adalah metode analisis regresi linier berganda. Berdasarkan hasil pengujian secara simultan diperoleh bahwa variabel Inflasi, Suku Bunga, dan Nilai Tukar secara simultan mempunyai pengaruh yang signifikan terhadap Indeks Harga Saham Gabungan Di Bursa Efek Indonesia, sedangkan secara parsial variabel Inflasi mempunyai pengaruh positif dan signifikan terhadap Indeks Harga Saham Gabungan Di Bursa Efek Indonesia., Suku Bunga mempunyai pengaruh positif dan signifikan terhadap Indeks Harga Saham Gabungan Di Bursa Efek Indonesia., dan Nilai Tukar mempunyai pengaruh negatif dan signifikan sekaligus dominan terhadap Indeks Harga Saham Gabungan Di Bursa Efek Indonesia.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KINERJA PADA TENAGA KERJA BANTUAN (HONORER) DINAS PERHUBUNGAN KOTA BALIKPAPAN
Authors: Cipto Ajeng
Published: September 2022

In carrying out the functioning of the government of the Balikpapan subdistrict government, the role of outsourced workers is needed to maintain the operational activities in the field. The number of outsourced employees reached 46 people who became total respondents in the implementation of their duties were divided into 10 groups of fields. With the number of operational workers that much, the performance of the transportation service is still considered low. Therefore this study aims to determine the effect of work discipline, compensation, work motivation and competention on the performance of outsourcing employees. Type of research used in this research is quantitative research method. Data collection techniques were conducted through interviews, questionnaires and observations. Testing The reliability of the questionnaire in this study was assisted by SPSS 21 software. The analysis technique used in this study was F-test, t-test and simultaneous discussion. The results of the F-test show that the variables of Work Discipline, Compensation, Work Motivation and Competention of Cooperation together (simultaneously) have an effect on outsourced employee performance, whereas from the T-test results,  motivation and Competention variables affect the performance when the work discipline and compensation variables have no effect significantly to performance. Based on the results of simultaneous test or F test F calculate can be concluded that the variable of Work Discipline, Compensation, Work Motivation  And Competention simultaneously have a significant influence on employees Performance.
PERBANDINGAN KINERJA KEUANGAN PERUSAHAAN SEBELUM DAN SESUDAH MERGER DAN AKUISISI YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Anani Putri , Gusnardi Gusnardi , Riadi RM.
Published: September 2022

Entering the era of globalization at this time and with the enactment of the free market, competition in the business world or business is getting tighter. This condition requires companies to be able to develop strategies. One strategy that can be done by the company is by conducting mergers and acquisitions. However, often the failure or deteriorating performance of the company occurs after the company conducts mergers and acquisitions. The purpose of this study is to compare the company's financial performance before and after mergers and acquisitions. This type of research is comparative research. The population in this study are all public companies listed on the IDX that have conducted mergers and acquisitions in the 2015-2016 period as many as 15 companies. The sample of this study amounted to 6 companies. The sampling technique used purposive sampling. This study uses secondary data. Data collection technique is documentation. The data analysis technique used is the Wilcoxon Signed Rank Test and thetest Manova. The results showed that partially there was no significant difference in the company's financial performance before and after mergers and acquisitions based on financial ratios, namely NPM, ROA, ROE, DER, EPS and TATO before mergers and acquisitions. Simultaneously there is no significant difference in the company's financial performance as measured by all financial ratios of NPM, ROA, ROE, DER, EPS and TATO before mergers and acquisitions.
Impacts of Mobile Phone and Social Media Use among the Medical Students of Chittagong
Authors: Akther Dr. Nahida , Uddin Dr. M Jalal , Deb Dr. Ajoy , Jahan Dr. Rifat , Sultana Dr. Kawsar
Published: September 2022

Now-a-days mobile phone has become an essential part of our life. However despite the convenience its use along with social media brings to affect our daily life in negative sense. The aim of the study is to explore the pattern of mobile phone and social media usage among the medical students of the Chittagong city, Bangladesh to observe the extent of addictive behavior towards the usage of mobile phone and social media. This will be an observational study. The study will be performed in different medical colleges of Chittagong for a period of 1 year. Responses on general and specific variables will be documented. Data will be collected with predesigned questionnaire. At the end of the study data will be analyzed by using windows based computer software devised with SPSS-23 using statistical method. Results will be published, presented and utilized for the quality usages of mobile phone and social media and betterment of our life.
The Impact of Financial Sector Development on Inflation in CEMAC
Authors: Georges Kobou , Dorcas Mbanga Pagal Emmanuelle
Published: September 2022

As an extension of existing empirical research, the paper shows that despite the structure of a financial sector, the financial sector development moves in opposite directions with inflation. Empirical verification using fixed-effects method from 2000 to 2018 in CEMAC countries provides datum about the theoretical hypothesis that there is negative relationship between inflation and financial sector development. Besides, results show that despite the low level of inflation target in CEMAC, the negative relationship between inflation and financial sector development exit and the credit risk associated to credit supply activity increases inflation in an important proportion. This increase of inflation reduces the performance of the financial sector and delays the central banker actions. The main policy recommendation addressed to monetary and financial policy actors in CEMAC is to improve strategies to contain the spillover effects due to the development financial sector.
Polymorphism of genes of immune-inflammatory response, thrombophilia, and arterial hypertension in kidney diseases in children (literature review)
Authors: Vyalkova A. A. , Zorin I. V. , Karymova G. K. , Chesnokova S. A.
Published: September 2022

Modern scientific data and the emergence of new opportunities for the development of pediatrics and nephrology are inextricably linked with medical genetics, the role of which is especially important for understanding the etiology and pathogenesis of many diseases of the urinary system. In 35–80 % of children with diffuse connective tissue diseases, kidney damage is formed, which is one of the leading causes of comorbidity of pathology and mortality of patients. Modern genetic research will allow not only to decipher the nature of diseases but also to scientifically substantiate adequate therapy. The active development of methods for the molecular diagnosis of kidney diseases opens up a large section of medicine, which can be called "molecular nephropathology". Further study of kidney diseases from the standpoint of molecular biology will allow us to take a fresh look at the pathogenesis of many diseases and solve a number of problems from the standpoint of personalized therapy, which takes into account the genetic characteristics of the patient. The active development of genetic research in nephrology has led to an understanding of the role of genetic mutations and polymorphisms leading to the occurrence of nephropathies in children. Correct clarification of the causes of the development of the disease can radically change the tactics of managing a patient by a nephrologist and rheumatologist. Determination of the genetic cause of the development of nephropathy is important in children since it justifies the need to examine other family members, it will allow predicting the risk of developing kidney pathology in diffuse connective tissue diseases, which is very important, predicting the response to immunosuppressive therapy. The development of molecular diagnostic methods is increasingly opening up prospects for a personalized approach to the study of pathology at various levels of interaction; these achievements provide a qualitative assessment of DNA, RNA, proteins, and their metabolites, which makes it possible to determine new biomarkers. The article deals with gene polymorphisms in secondary nephropathies in children with diffuse connective tissue diseases (systemic lupus erythematosus, systemic microthrombovasculitis, rheumatoid arthritis).
Comparative efficacy of mycophenolic acid and cyclosporine A in treatment of children with steroid-dependent nephrotic syndrome
Authors: Rusakova E. S. , Petrosyan E. K. , Molchanova M. S. , Gavrilova V. A. , Ryzhova A. V. , Kushnir B. L. , Povilaitite P. E. , Shumilov P. V.
Published: September 2022

BACKGROUND. Steroid-dependent nephrotic syndrome (SDNS) treatment is still an important problem in pediatric nephrology since the proper use of steroid-sparing agents can reduce the frequency of relapses and avoid steroid toxicity.

   THE AIM of our study was to compare the efficacy of cyclosporine A (CsA) and mycophenolic acid (MPA) in children with SDNS.

   PATIENTS AND METHODS. We observed 91 children (30 girls, 61 boys) with SDNS in 2015-2020. Age at the disease debut was 3 years [2,1; 5,0]. The age at steroid-sparing therapy debut was 8 years [4,0; 16,0]. All children received standard clinical and laboratory examinations and kidney biopsy.

   RESULTS: 25 children were treated with CsA, and 66 children were treated with MPA. The steroid-sparing therapy duration was 36 months [29; 44]. The frequency of relapses before the steroid-sparing therapy onset was 1,32 ± 0,62 (0,5; 4,3)/year, during steroid-sparing therapy it became 0,5 ± 0,58 (0; 2)/year (р < 0,05). Relapse rate in the MPA group was 0,36 ± 0,49 (0; 1,76)/year compared to 0,85 ± 0,66 (0; 2)/year in the CsA group (p < 0,05). Withdrawal of prednisolone was achieved in 44 (48,4 %) children. The relapse-free period during steroid-sparing therapy with steroid withdrawal was 25 months [6; 120]. 15 children (16,5 %) showed long–term stable remission with no immunosuppressive therapy. 14 of them were treated with MPA and only one with CsA (χ2=9,7, р = 0,0021). The remission duration was 7-32,9 months. There were no severe side effects of CsA and MPA requiring discontinuation of therapy.

   CONCLUSION: steroid-sparing therapy of SDNS with CsA and MPA significantly reduces relapse frequency. Relapse risk in patients treated with CsA was significantly higher than with MPA. So, it is justified to prescribe MPA as a first-choice immunosuppressive therapy in patients with SDNS.
Vigilantes do Sono amplia atuação e passa a cuidar também de ansiedade e depressão
Authors: Sherlock Comms
Published: September 2022

A partir do segundo semestre, a startup contará com novas jornadas desenvolvidas para outras condições, como: depressão e ansiedade; a healthtech reconhecida por oferecer terapia para insônia, contará com novo método voltQado às mulheres na menopausa e para trabalhadores noturnos ou em turnos que estejam com problemas com o sono
Demonstrativo do crescimento de cepas multirresistentes fora do ambiente de UTI em hospital referencia em infectologia
Authors: Maranhão da Cruz Walkiria Maria , Damasceno de Jesus Lucely , Pimentel Assis Ronny , Salles Arraes Pedrosa Barreto Antônio , Brito Albuquerque de Oliveira Priscila , Ribeiro da Silva Andreia , Amaral Dantas Taís , De Souza Lopes Suliete , De Souza Rezende Ariana Mayza , Portela de Azevedo Arimatéia
Published: September 2022

Introdução: Atualmente existem muitos microrganismos resistentes a diferentes classes de antimicrobianos e são considerados como importante causadores de infecções hospitalares pela fácil transmissibilidade de uma pessoa à outra por meio do contato das mãos e de materiais contaminados. Objetivo: Descrever perfil de cepas resistentes e os possíveis fatores predisponentes para o aparecimento destas em pacientes imunossuprimidos internados em enfermarias de um hospital de referência em infectologia. Metodologia: Estudo do tipo retrospectivo, descritivo com uma abordagem quantitativa. Resultados: O perfil microbiológico de resistência observado nas culturas de pacientes internados nas enfermarias de um hospital referência em infectologia mostrou que, 58% das infecções eram causadas por Escherichia coli seguidos por 22,5% Klebsiella pneumoniae e 19,5% Pseudômonas aeruginosa. Em relação ao perfil de resistência, 12,5% eram resistentes aos carbapenêmicos de espectro estendido, 12,5% as cefalosporinas de 4° geração e 12,5% as cefalosporinas de 3° geração. Também foram analisadas informações existentes em 98 planilhas com registros de auditorias internas, destas, 57% continham erros cometidos por servidores e estas não-conformidades poderiam estar intimamente ligadas a contaminação intra-hospitalares, o restante (43%) eram relacionadas ao ambiente. Conclusão: O estudo mostra que para auxiliar na prevenção da quebra de cadeia de transmissão de bactérias multirresistentes se faz necessário a instauração de protocolos de cultura de vigilância que se resume na coleta de amostras de pacientes internados ou que necessitam de internação, principalmente em unidades onde albergam pacientes imunossuprimidos.
Os benefícios da fotobiomodulação nas complicações da mastoplastia de aumento: um relato de experiência
Authors: Neves da Silva Marilene , Vieira-Damiani Gislaine , Aparecida Masson Valéria , Cezar Castilho João , Gonçalves de Oliveira Pedro
Published: September 2022

Objetivo: Apresentar os resultados obtidos no tratamento com fotobiomodulação associado as terapias tópicas de hidrogel e ácido hialurônico 0,2% (AH) em lesões por deiscência cirúrgica de mastoplastia de aumento. Metodologia: Trata-se de um estudo descritivo exploratório de relato de experiência de uma mulher, 26 anos, sem comorbidades, que desenvolveu deiscência de sutura após submeter-se a uma mastoplastia de aumento. Na abordagem inicial, preconizou-se o protocolo com aplicação semanal de fotobiomodulação (660nm) combinado com administração tópica diária de hidrogel. Na finalização do tratamento optou-se pelo uso tópico de AH 0,2% , visando a melhora da estética do processo cicatricial. A análise dos efeitos dos tratamentos foi realizada por meio de registro fotográfico com câmera digital 16 megapixels, a uma distância de 20 centímetros. As imagens foram examinadas por meio do software ImageJ. Resultados: O fechamento da lesão ocorreu após 90 dias do início do tratamento. A reparação tecidual apresentou ótima cicatrização após tratamento tópico diário com hidrogel, sem prejuízo da área adjacente à lesão. Não foram observados eventos adversos locais ou sistêmicos durante o período de estudo da lesão. Os resultados permitem constatar que a aplicação tópica de hidrogel e AH associada a fotobiomodulação em lesões do tipo deiscência contribuiu para acelerar a cicatrização, melhorou a evolução das lesões e o resultado estético no caso estudado. Conclusão: É possível inferir que a fotobiomodulação associada à terapia tópica de hidrogel pode ser indicada como recurso importante para potencializar os processos biológicos envolvidos com a recuperação de lesões tipo deiscência. Já o uso tópico de AH evidenciou melhora da remodelação dérmica e da hiperpigmentação e diminuição dos sinais de hipertrofia.