bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of a Life Skills Enhancement Program on the Life Skills and Risk Behaviors of Social Media Addiction in Early Adolescence
Authors: Kumkronglek Jedbordin , Sirisatayawong Pornpen , Chupradit Supat
Published: January 2023

Objective:

This research aimed to develop and investigate the effects of a life skills enhancement program on the life skills and risk behaviors of social media addiction in early adolescence.

Methods:

This research used a quasi-experimental design for a controlled study with a pre-test and post-test that collected data through a general information questionnaire, Social Media Addiction Screening Scale: S-MASS, and a life skills test. There were 48 samples recruited by purposive sampling from 5 schools in Chiang Mai, Thailand. The life skills enhancement program was developed under the theory of cognitive and behavioral therapy in combination with group therapy or occupational therapy. The program had a total of 10 sessions, with 1 session per week for 60 minutes and 10 weeks in total.

Results:

For the results, a statistically significant difference in post-test SMASS scores between the control and experimental group was found (p<0.01). Moreover, a statistically significant difference in the experimental group between pre-test and post-test using S-MASS scores decreased significantly after participating in the program but not in the control group. This result is similar to the comparative data of life skills scores that revealed there was a statistically significant difference between the pre-test and post-test only in the experimental group. For the comparative data between the control and experimental group, however, there were no statistically significant differences in pre-test and post-test life skills scores between the two groups.

Conclusion:

From the results, it can be summarized that the life skills enhancement program had affected an increase in life skills and a decrease in risky social media usage among adolescents.
Patent and Marketing Exclusivities 101 for Drug Developers
Authors: Oronsky Bryan , Caroen Scott , Brinkhaus Franck , Reid Tony , Stirn Meaghan , Kumar Raj
Published: January 2023

Despite an ever-increasing need for newer, safer, more effective, and more affordable
therapies to treat a multitude of diseases and conditions, drug development takes
too long, costs too much, and is too uncertain to be undertaken without the conferment of
exclusionary rights or entry barriers to motivate and sustain investment in it. These entry
barriers take the form of patents that protect intellectual property and marketing exclusivity
provisions that are provided by statute. This review focuses on the basic ins and outs of
regulatory and patent exclusivities for which new chemical entities (NCEs), referring to
never-before approved drugs with an entirely new active ingredient, are eligible and uses
RRx-001, a small molecule aerospace-derived NCE in development for the treatment of
cancer, radiation toxicity, and diseases of the NLR family pyrin domain containing 3
(NLRP3) inflammasome, as a “real world” example. This is intended as a ‘101-type’ of
primer; its aim is to help developers of original pharmaceuticals navigate the maze of
patents, other IP regulations, and statutory exclusivities in major markets so that they can
make proper use of them.
Effect of Ice Bag Application to Femoral Region on Pain and Vital signs in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Randomized Controlled Trial
Authors: Sokhanvar Shima , Tirgari Batool , Forouzi Mansooreh Azizzadeh , Salari Mehdi , Jahani Yunes
Published: January 2023

Background:

Patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI) experience a great deal of pain and discomfort in the femoral region induced by femoral catheter removal, which can stimulate the sympathetic system and affect some vital signs.

Objective:

The aim of this study was to determine the effect of ice bag application to femoral region on pain and vital signs in patients with acute MI undergoing PCI.

Methods:

This is a double-blind randomized controlled trial study. The sample of this study consisted of 60 patients with acute MI undergoing PCI, including 30 patients per group, selected by convenience sampling method and assigned to intervention and control groups by block randomization method. The intervention included the use of an ice bag in the femoral catheter insertion site. Data collection tools included demographic information form, Numerical Rating Scale (NRS), and vital signs form. Femoral site pain and vital signs were measured in both groups before, during, and after femoral catheter removal. The data were entered into SPSS ver. 22. Using descriptive statistics, Chi-square and Mann Whitney test, data were analyzed.

Results:

Two groups were matched in terms of all demographic and disease-related variables (p>0.05). Pain score was lower in intervention group than in control group during and after the intervention (p<0.0001). Also, systolic, diastolic blood pressure, and temperature scores of the patients in the intervention group were significantly lower than the control group during and after catheter removal (p<0.05). Respiratory rate of the intervention group was significantly lower than the control group (p = 0.005). No significant difference between the two groups in the mean of heart rate in all three time periods (p>0.05).

Conclusion:

Application of the ice bag on the femoral region is effective in stabilizing the vital signs and decreasing the pain caused by femoral catheter removal in MI patients undergoing PCI. Therefore, considering its low cost and complications, topical application of an ice bag, as a nursing intervention to control the pain and keep stable vital signs, is recommended.

Clinical Trial Registration No:IRCT201511070249191N7.
Factors Influencing Quetiapine Pharmacokinetic Variability: A
Review of Population Pharmacokinetics
Authors: Methaneethorn Janthima
Published: January 2023

Atypical antipsychotic quetiapine (QTP) exhibits high pharmacokinetic variability
and population pharmacokinetic (PopPK) analysis is one of the approaches used to characterize
factors influencing QTP pharmacokinetic variability. Though QTP is not regarded as a narrow
therapeutic index drug, knowledge of this area is of importance. Thus, this review was conducted
to summarize significant predictors for QTP pharmacokinetic variability identified using
a PopPK analysis and to explore any knowledge gaps to be investigated. PubMed, Scopus,
and CINAHL Complete databases were searched for eligible studies, and 75 articles were identified.
Of these, only five studies were included as they were conducted using a nonlinear
mixed-effects approach. This review found that only limited predictors for QTP pharmacokinetics
were identified, with body weight being a predictor for the volume of distribution and
age and γ-glutamyl transpeptidase being predictors for QTP clearance. None of the studies included
elderly patients aged >65 years, and thus factors associated with aging were not investigated.
Also, most of the participants in the PopPK analyses were from clinical trials which
might not reflect real-world patients e.g., the impacts of polypharmacy may not be available.
Moreover, while a population pharmacokinetic-pharmacodynamic model explaining QTP exposure
and clinical response using the scores of the Brief Psychiatric Rating Scale is available,
knowledge relevant to the relationship between exposure and QTP side effects has not been
explored. Based on this limited information, future PopPK research encompassing a wide range
of patient characteristics is required.
Pre-Clinical and Clinical Evidence of Recent Therapeutic Trends and Spotting Possibility of Cure in Near Future
Authors: Muraleedharan Amitha , Kumar Sagar , Mittal Rashmi
Published: January 2023

Substantial cohort studies, pre-clinical, clinical trials, and in-depth genomic
and proteomic analysis underlie that several molecular alterations exist in TNBC that
may be favorable or detrimental to cancer progression. Molecular heterogeneity in
TNBC has shortened the disease-free survival rate in response to adjuvant and
neoadjuvant therapies. To determine possible vulnerabilities in TNBC, several drugs
were under investigation. This chapter highlighted the current paradigm of the
therapeutic approach including surgery, radiotherapy, and chemotherapy. In this
review, we also highlighted the clinical trials involved in the management of TNBC by
targeting angiogenesis, apoptosis, androgen receptors, cell cycle, and pro-survival
signalling pathways. To overcome the constraints associated with the mono-therapeutic
approach, pre-clinical and clinical studies of combinational therapy have also been
discussed to improve OS, DFS, and DMFS in TNBC patients. 
Herbal Medicine: Prejudice to Realm of Reality Against TNBC
Authors: S. Vinod Balachandran , John Anto Ruby
Published: January 2023

In triple-negative breast cancers, there exist tumor-specific vulnerabilities
that can be targeted to avoid compensatory adaptation of cancer cells in response to
standard pharmaceutical therapies. Natural moieties are well-known to possess a
multitude of medicinal properties and deserve attention for TNBC prevention and
therapy. To overcome drug resistance and efficacy issues, the exploration of natural
moieties as targeting agents may emerge as dynamic, promising, and new therapeutic
strategies to benefit TNBC patients. This chapter summarizes the role of
polysaccharides, flavonoids, phenols, saponins, and taxanes in targeting TNBC. The
potent role of herbal medicine in targeting molecular signalling pathways with special
emphasis on their ability to target uncontrolled proliferation, metastasis, angiogenesis,
and autophagy has also been discussed. Furthermore, the ability of herbal medicine in
inhibiting PI3K/Akt/mTOR, STAT3, and Wnt/β-Catenin has also been explored.
Combinational therapy comprising chemotherapeutic drugs and active plant
constituents was also explored to overcome the complications of TNBC. 
An Analysis of the Curriculum Ideology in the Lesotho General Certificate of Secondary Education English Language Syllabus
Authors: Moea Kananelo Sylvester
Published: January 2023

The role of the English Language is undeniable in maintaining the growth and development of skilled workforces that are globally compatible. This study sets out to analyze the curriculum ideology of the Lesotho General Certificate of Secondary Education (LGCSE) English Language syllabus. The study was qualitatively conducted through the use of document analysis- analyzing the syllabus document. The findings reveal that the LGCSE English Language syllabus has the four curriculum ideologies, though in varying degrees. It appears that the dominant ideology in this syllabus is the learner-centered ideology which appears in four syllabus aims, followed closely by social efficiency appearing in three aims, the social reconstruction appearing in two aims. Trailing behind is the scholar’s academic ideology appearing in one syllabus aim. This LGCSE English Language syllabus positions a learner largely as an affiliate of society and also one who can function effectively in various milieus in a society. The current study suggests curriculum ideology awareness programs should be given to teachers and prospective teachers of the English Language to assist them in their teaching of the English Language. The study also recommends that a survey study can be conducted on teachers and teacher educators before designing the national curriculum of Lesotho because much curriculum is affected by the ideology of the teacher.
Estrategias para mantener las funciones cognitivas en adultos mayores
Authors: Sánchez-Nieto José Miguel
Published: January 2023

Entre los problemas de salud que pueden limitar la independencia y autonomía de las personas adultas mayores, se encuentran la enfermedad de Alzheimer y la demencia vascular, además otros padecimientos que pueden afectar las funciones cognitivas, como el deterioro cognitivo leve. Para evitar o retardar la pérdida de la funcionalidad por una disminución en las funciones cognitivas, se han propuesto varias estrategias como la alimentación, el ejercicio, la participación social e intervenciones específicas para mejorar la cognición. En este sentido, la integración de dichos estilos de vida son la mejor opción, para mantener y prolongar la funcionalidad cognitiva.
The safeness of Ramadan intermittent fasting among patients who undergone primary Percutaneous Coronary Intervention
Authors: Amen Shwan , Rasool Banan , Rashid Alaa , Shakir Sara , Qadr Parez , Shawkat Asia , Abdulkarem Rangen , Yousif Salah , Lucero-Prisno Don , Shehata Dina
Published: January 2023

Objective: This study aims to assess the ability and the safety of fasting among patients who underwent PPCI within two specified periods.
Methods: This study was a Retrospective Cohort Study with a convenience sample size of 200 consecutive patients who were divided into two groups based on the duration of their last primary PCI for an attack of acute myocardial infarction (AMI) and the start of the month of Ramadan. The patients were admitted to the Causality Department of the Surgical Specialty Hospital-Cardiac Center, Erbil/Iraq. Group I included patients undergone PPCI 6 weeks or less before the start of Ramadan while group II included patients undergone PPCI for more than 6 weeks before the start of the fasting month of Ramadan. Furthermore, each of these two groups was subdivided based on their ability to complete the Ramadan Intermittent Fasting (RIF) with no recurring or worsening of symptoms into those who fasted the whole Ramadan month, those who did not fast, those who could not continue fasting, and those who passed away. At the end of the RIF, patients’ symptoms were recorded along with their status according to the New York Heart Association (NYHA).
Results: In a comparison of the proportion of fasting and non-fasting patients among the two groups, 14% in group I were able to complete the 30 days of intermittent fasting during the Ramadan month while this percentage in group II was 54% (P-value=0.001). Among our findings, there were significant associations between post-PCI symptoms (exertional shortness of breath and palpitations) and RIF (P-values=0.001and P-values=0.004, respectively). With regards to New York Heart Association (NYHA) classifications assessment, Group I had a higher proportion of patients classified as Class III and Class IV compared to Group II (P-value=0.001) meaning patients were more symptomatic during the lesser interval between the start of the fasting month and the primary PCI. 
Conclusion: Patients with PPCI within the first 6 weeks after the procedure, as well as patients with NYHA class III, are at a higher risk for health deterioration and are advised not to observe RIF.
TAX REVENUE ASSESSMENT FROM THE PERSPECTIVE OF IMPLEMENTING THE STATE FISCAL POLICY IN MODERN CONDITIONS
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Елена Николаевна Голик
Published: January 2023

The sanction impact on the country's economy and its financial system necessitated the use of internal reserves and opportunities, which was a priority in the development of the tax system. The work analyzes tax revenues to the state budget from the standpoint of implementing the main directions of tax policy determined by government documents. It is concluded that the modern tax system demonstrates the stability of foreign economic challenges, which is confirmed by the positive dynamics of tax revenues at all levels of the budget system. The article justifies that these results were achieved not only due to an increase in economic activity of businesses and households, improvement of tax administration procedures, but also an increase in consumer prices for goods, energy raw materials and products of its processing. In order to neutralize tax pressure on consumption and increase the level of social justice in society, it is proposed to transfer part of the tax burden to the highly profitable part of the population, as well as continue to work towards further increasing the fiscal significance of rent payments, ensuring the growth of the tax base of the real sector of the economy.
SUGGESTIONS FOR IMPROVEMENT THE PERFORMANCE ASSESSMENT METHODOLOGY FOR SUBORDINATE ORGANIZATIONS OF THE MINISTRY OF PHYSICAL CULTURE AND SPORTS IN THE ROSTOV REGION
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Мария Николаевна Аширова , Анна Дмитриевна Черкасская ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

The article provides performance assessment methodology for subordinate organizations of the Ministry of Physical Culture and Sports, which differs from the existing one in a wider range of monitoring agents (supervisors and coachers), and in the extended number of sports indicators, including the group of scoring gradation indicators and the formation of a complex parameter, which allows to optimize the distribution of incentive allowances.
JOINT CONSUMPTION IN THE WORLD ECONOMY: INNOVATIVE TRENDS IN THE CONDITIONS OF DIGITALIZATION
Authors:   Ростовский государственный экономический университет (РИНХ), Ростов-на-Дону, Россия, Петр Владимирович Таранов , Александр Михайлович Басенко ,   Ростовский государственный экономический университет (РИНХ), Ростов-на-Дону, Россия
Published: January 2023

This article is devoted to the analysis of the sharing economy, within which innovative trends have emerged related to digital technologies and the process of total digitalization. The authors identify three innovative basic levels of the sharing economy (macro-, meso- and microeconomic), which are based on digital technologies. As new trends in the sharing economy, the following are given: joint investment in innovative economic ideas, joint ownership of a company, crowdsourcing, freelancing, the crown of which is the online sharing economy.
WESTERNIZATION AS A THREAT TO THE RUSSIAN NATIONAL MENTALITY IN THE CONTEXT OF THE PROTECTION OF STATE NATIONAL SECURITY
Authors:   Северо-Западный институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте Российской Федерации, Санкт-Петербург, Россия, Андрей Андреевич Ковалев
Published: January 2023

The purpose of this study is to examine the detrimental impact of Westernization processes on the national mentality as an integral part of the national security of the state. The following scientific approaches and methods were used: axiological approach, historical approach, as well as analysis and political forecasting. Modern Russia is facing a difficult task - to protect its national interests and defend its independence in the international arena, as well as to reverse the processes of Westernization that have begun inside the country and minimize the negative consequences from them. The author concludes that only an equitable dialogue between all states is able to form a just world order. The unipolar world is outdated, demonstrating its practical inconsistency. And Westernization as a synonym for globalization (which, incidentally, the modern world needs) has not resonated with many countries of the non-Western world.
KEY CONCEPTS IN POLITICAL RISK RESEARCH
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Елизавета Александровна Морозова
Published: January 2023

Today, the issue of risks is given great importance, which is associated with an increase in their role due to the processes of globalization. Their main feature is that they penetrate into completely different spheres of public life, creating total uncertainty. In addition, they are different from the dangers of pre-industrial society, which were local in nature and did not pose such threats to humanity. In connection with the global spread of modern risks, the directions of their research are constantly expanding, and the methodological apparatus is being improved. Their analysis occupies an important part in the decision-making process, including in political activity.
POLITICAL ANALYSIS OF IMPERIAL STATEHOOD
Authors:   Ростовский филиал Российского государственного университета правосудия, Ростов-на-Дону, Россия, Андрей Викторович Семенов
Published: January 2023

The article is devoted to the emergence and development of imperial statehood. Its analysis is carried out from the standpoint of political science. The definition of empire is formulated and its typological features are highlighted. The development of imperial systems in the past and present is considered. Special attention is paid to the Bonapartist empires of the XIX century. The specifics of the development of the Russian Empire and the problems of imperial statehood at the present stage are analyzed. The colonial aspect of imperial statehood is considered. The reactionary nature of the fascist empires of the mid-twentieth century is shown and the main features of US imperial liberalism are highlighted.
DEVELOPMENT OF PROPOSALS FOR OPTIMIZING THE MANAGEMENT STRUCTURE IN THE MINISTRY OF HOUSING AND COMMUNAL SERVICES OF THE ROSTOV REGION
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Анастасия Васильевна Скидан , Ксения Сергеевна Архипова ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

The article presents a historical overview of the formation and development of the housing and communal services of the Russian Federation, in particular the Rostov region. The analysis of the current management structure of the Ministry of Housing and Communal Services of the Rostov Region is carried out, its problems are identified through case methods, brainstorming, methods for conducting foresight sessions, methods of reflection and questioning. In order to solve the identified problems, proposals were developed to optimize the management system and staffing of the Ministry of Housing and Communal Services of the Rostov Region, and the effectiveness of the proposed solutions was also assessed as a result of testing the study.
FORMING BUSINESS COMMUNICATION OF FUTURE ECONOMISTS: FROM THE EDUCATION PHILOSOPHY TO THE LABOR MARKET
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Нина Сергеевна Котова , Людмила Аврамовна Томашевская ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Нина Анатольевна Колесникова ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Елена Александровна Гельпей ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

The article is devoted to the training of future economists in business communication in English. The article describes the specifics, functions, principles of the system for preparing future economists for business communication in accordance with the requirements of employers. A pedagogical experiment was carried out: the appropriate pedagogical conditions and the author's program were created to form the communicative competence of students in situations of business and professional communication), control and formative testing was carried out, and the analysis of the results obtained was carried out.
DEVELOPMENT OF PROPOSALS FOR AMENDMENTS TO THE CODE OF ADMINISTRATIVE OFFENCES OF THE RUSSIAN FEDERATION REGARDING CHANGES IN ADMINISTRATIVE FINES FOR VIOLATIONS OF ENVIRONMENTAL LEGISLATION, AS WELL AS THE LAW ON SUBSOIL
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Юлия Алексеевна Героева , Альберт Аршакович Карапетян ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

In the Russian Federation, statistics on the number of offenses in the field of environmental protection activities are increasing every year, in particular, for illegal extraction of minerals and the subsoil of the earth. In the article, the author draws attention to the commission of a large number of administrative offenses for the use of mineral resources without a license for the use of mineral resources or violation of the conditions provided for by the license for the use of mineral resources, as well as the need to amend the Code of the Russian Federation on Administrative Offenses in terms of increasing the administrative fine for violation of part 1, chapter 7.3 of Article Administrative Code of the Russian Federation.
Auditing quality between share price and liquidity regarding investor’s decision
Authors: Thuneibat Nawaf , AlHalaseh Rula Hani
Published: January 2023

Financial statements and the fact that many investors depend on the most critical outputs of the auditing quality. We documented the impact of audit quality as measured by audit firm size, tenure, fees, and firm experience on the stock prices and the liquidity of stock companies listed on the Amman Stock Exchange (ASE). The research adopted the deductive approach considering the least squares dummy variable approach following Pham et al. (2020), Sumiadji et al. (2019), Ugwunta et al. (2018), and Al-Thuneibat et al. (2011) to study the relationship between time-varying predictors and outcomes of 185 shareholding companies listed on ASE from 2016 to 2020. The characteristics of an audit firm vary in their effects on both the stock price and the liquidity. Management of the listed companies should be discussed to address the barriers that limit the impact of audit quality on the reliability of information associated with financial statements aiming to reduce information asymmetry and boost investor confidence, and then the share price should rise, and smaller audit firms should be encouraged to perform more specific audit assignments.
Vascularization underlies differences in sexually selected skin coloration in a wild primate
Authors: DeLacey Patricia , Sen Sharmi , Scheider-Crease India , Chiou Kenneth , Lemma Alemayehu , Ayele Ferehiwot , Haile Abebaw , Lu Amy , Bergman Thore , Beehner Jacinta , Snyder-Mackler Noah
Published: January 2023

Male reproductive competition can select for condition-dependent,
conspicuous traits that signal some aspect of fighting ability and
facilitate assessment of potential rivals. However, the underlying
mechanisms that link the signal to a male’s current condition are
difficult to investigate in wild populations, often requiring invasive
experimental manipulation. Here, we use digital photographs and chest
skin samples to investigate mechanisms of a visual signal used in male
competition in a wild primate, the red chest patch in geladas
(Theropithecus gelada). We analyzed photographs collected during natural
(n=144) and anesthetized conditions (n=38) to understand variability in
male and female chest redness, and we used chest skin biopsies (n=38) to
explore sex differences in gene expression. Male and female geladas
showed similar average redness, but males exhibited a wider
within-individual range in redness under natural conditions. These sex
differences were reflected at the molecular level, with 10.5% of genes
exhibiting significant sex differences in expression. Subadult males
exhibited intermediate gene expression patters between adult males and
females, pointing to mechanisms underlying the development of the red
chest patch. We found that genes more highly expressed in males were
associated with blood vessel development and maintenance but not with
androgen or estrogen activity. Together, our results suggest male gelada
redness variability is driven by increased blood vessel branching in the
chest skin, providing a potential link between male chest redness and
current condition as increased blood circulation to exposed skin could
lead to heat loss in the cold, high-altitude environment of geladas.
Trends in the Prevalence and Treatment of Diabetic Macular Edema and Vision-Threatening Diabetic Retinopathy Among Commercially Insured Adults Aged <65 Years
Authors: Lundeen Elizabeth A. , Kim Minchul , Rein David B. , Wittenborn John S. , Saaddine Jinan , Ehrlich Joshua R. , Holliday Christopher S.
Published: January 2023

  

Objective: Examine the ten-year trend in the prevalence and treatment of diabetic macular edema (DME) and vision-threatening diabetic retinopathy (VTDR) among commercially insured adults with diabetes.

Research Design and Methods: We analyzed the ten-year trend (2009–2018) in healthcare claims for adults 18–64 years using the IBM® MarketScan® Database, a national convenience sample of employer-sponsored health insurance. We included patients continuously enrolled in commercial fee-for-service health insurance for 24 months who had a diabetes ICD-9/10-CM code on ≥1 inpatient or ≥2 different day outpatient claims in the index year or previous calendar year. We used diagnosis and procedure codes to calculate the annual prevalence of patients with ≥1 claims for: 1) any DME, 2) either DME/VTDR, and 3) anti-vascular endothelial growth factor injections [anti-VEGF] and laser photocoagulation treatment, stratified by any DME, VTDR with DME, and VTDR without DME. We calculated Average Annual Percent Change (AAPC).

Results: From 2009–2018, there was an increase in the annual prevalence of patients with DME/VTDR (2.1% to 3.4%; AAPC=7.5%; p<0.001) and any DME (0.7% to 2.6%; AAPC=19.8%; p<0.001). There were sex differences in the annual prevalence of DME/VTDR and any DME, with males having a higher prevalence than females. Annual claims for anti-VEGF increased among those with any DME (327%) and VTDR with DME (206%); laser photocoagulation decreased among patients with any DME (-68%), VTDR with DME (-54%), and VTDR without DME (-62%). 

Conclusions: Annual claims for DME/VTDR and anti-VEGF injections increased while laser photocoagulation decreased among commercially insured adults with diabetes.
PERAN HUMOR TOKOH NAGABONAR DALAM SKENARIO FILM NAGABONAR KARYA ASRUL SANI
Authors:   SMP Yasmida Ambarawa, Abidin Mukhtar , Rama Ratna Fauzi ,   SMKN 1 Negerikaton Pesawaran
Published: January 2023

This article proves the film scenario as a literary work, and discusses the role of humor in Nagabonar characters and jokes about the values of the struggle for independence in Asrul Sani's Nagabonar film scenario. The method used is Charles Sanders Peirce's semiotics and the study of humor in a psychological perspective. The results of the analysis obtained based on structural analysis in the perspective of text communication prove that a film scenario is a textual work that can be studied based on the nature of a literary work. And an analysis of humor created and acting as a response or self-defense mechanism to the Nagabonar character, as well as a reversal of the concept and logic of stereotypes of heroism in Indonesia.
Molecular Detection of the Effect of Malaria Infection on Nutritional Status in Paediatrics Attending Primary Health Care Hospitals (PHC) Around Sokoto Metropolitan, Sokoto, Nigeria
Authors: Suleiman Jafaru , Lema Sani Y. , Isyaku Nike T.
Published: January 2023

Molecular diagnosis is now considered to be the most efficient and reliable method for detection of malaria parasites; hence the present research was designed to access the effect of malaria infection on the nutritional status of the pediatrics attending PHC in Sokoto, 400 children were recruited randomly, nutritional status was determined using mid-upper armed circumference (MUAC) tape, blood samples was collected then subjected to Nested Polymerase Chain Reaction (nPCR) test. Out of 400 samples analyzed, 199/400 (49.75%) were acutely malnourished, 117/400 (44.25%) were normal and 84/400 (21.00%) were severely malnourished. Although 237 (59.25%,) were found positive for Plasmodium falciparum, those that are severely malnourished had the highest infection rate [78/84 (92.86%)] followed by those that are normal [124/199 (62.31%)] than those that were acutely malnourished [35/84 (41.67%)], a significant association was reported for those that are severely malnourished based on parent’s occupation (P=0.001), place of living (P=0.000), and sleeping under nets (P=0.012), there was also significant relationship in those that are normally based on gender (P=0.001), and sleeping under nets (P=0.021) only while those that were normal showed significant relationship based on sleeping under nets (P=0.001) and parents occupation (P=0.000). The high prevalence of malaria in the study demonstrates high sensitivity and specificity of molecular diagnosis. There is a need to embark on massive community campaigns and adoption of mosquito control measures in the study area.
Manejo integral de residuos en una empresa prestadora de servicios de aseo: propuesta de mejora
Authors: Ramírez Alejandro , Carvajal Flórez Elizaberh
Published: January 2023

El aumento en las actividades industriales ha llevado a una mayor producción de residuos sólidos, el mal manejo de éstos impacta negativamente el medio ambiente y la salud humana, por tanto, se tiene la necesidad de promover la correcta gestión de residuos a nivel nacional, regional y local. el objetivo de este estudio es actualizar las tasas de generación e identificación de las problemáticas asociadas a la gestión de residuos, para poder formular una propuesta de mejora para el Manejo Integral Residuos Sólidos (no peligrosos) que se lleva a cabo en dos sedes principales de una empresa prestadora del servicio público de aseo. En una primera fase se recopilaron las características generales de las sedes mediante una búsqueda en la página oficial de la empresa. En la segunda fase se realiza un diagnóstico de la situación actual del manejo de los residuos mediante visitas de campo, diligenciamiento de listas de chequeo, registro fotográfico, entre otros. Posteriormente se ejecutó la caracterización y cuantificación de los residuos siguiendo los lineamientos del Manual para el Manejo Integral de Residuos en el Valle de Aburrá y la norma técnica ASTM D5231–92. Finalmente se evaluó si las actividades de gestión ambiental están en concordancia con los aspectos técnicos y normativos para posteriormente formular las medidas de manejo que optimizarían la gestión interna de residuos. Como resultados obtuvimos que la base de operaciones y mantenimiento es la que mayor generación de residuos posee con un promedio de 12,81 kg/día, levemente mayor que los 9,90 kg/día de la sede administrativa. En ambas sedes los residuos aprovechables son los que mayor participación tienen, representando el 49,31% y el 45,25%; para base de operaciones y sede administrativa, respectivamente. Las tasas de generación están por debajo de algunas empresas del sector manufacturero y educativo.
Peculiarities of disciplinary responsibility of professional athletes
Authors: Kyselova O.
Published: January 2023

The article is devoted to the study of the peculiarities of the disciplinary responsibility of professional athletes. The article reveals the meaning of the concept of disciplinary responsibility, the features of a professional athlete's disciplinary offense, and the specifics of bringing an athlete to disciplinary responsibility. Within the framework of the article, the issue of the admissibility of applying certain types of sanctions, particularly a fine, will also be investigated, and attention will be paid to the point of responsibility for violation of the sports regime. The issue of disciplinary responsibility of this category of employees is relevant and necessary to study in connection with the lack of a clear understanding of the specifics of the mentioned institute, the lack of distinction between disciplinary responsibility and other types of legal responsibility, as well as some other problems that arise when applying disciplinary sanctions to athletes professionals’ Legal regulation must be effective and meet the requirements of the time. The completeness of the liability rules is a guarantee of ensuring the constitutional rights of subjects of labor relations. Detailing the rules on disciplinary responsibility allows for the definition of clear boundaries of acceptable behavior for the employer and necessary behavior for the employee. The disciplinary responsibility of athletes is fully established depending on the specific sport by disciplinary statutes, regulations, regulations rules of the relevant international sports federations, national sports federations, clubs, and associations. Therefore, the legal regulation of the activities of professional athletes differs from the general regulation, has its characteristics, and requires special attention from the legislator. In particular, the article focuses attention on the need to introduce special disciplinary responsibilities for professional athletes, in particular through the adoption of a special law regulating the professional activity of athletes. The article proposes other measures to improve the current labor legislation.
Comparative analysis of deposit operations of the largest commercial banks in Russia
Authors: Spiridonov S. P. , Petrenko N. A.
Published: January 2023

The article presents a comparative analysis of deposit operations of Sberbank, VTB Bank and Russian Agricultural Bank for 2020–2021. In all banks over the period presented, there has been an increase in the volume of the deposit portfolio, the largest share of which is accounted for by funds of individuals and corporate clients.
Diabetic foot assessment using skin impedance in a custom made sensor-sock
Authors: Tronstad Christian , Amini Maryam , Olesen Eline , Qvigstad Elisabeth , Pabst Oliver , Martinsen Tormod , Abie Sisay M. , Martinsen Ørjan G. , Hisdal Jonny , Jenssen Trond G. , Kalvøy Håvard
Published: January 2023

Diabetic peripheral neuropathy (DPN) may lead to several changes in the skin, and some of these may influence the skin impedance spectrum. In the present study we have developed a prototype solution for skin impedance spectroscopy at selected skin sites (big toe pulp, heel and toe ball) that was tested in a pilot study on five patients with DPN and five healthy controls. At the big toe, most of the controls had markedly lower impedance than the DPN group, especially in the range of 1-100 kHz. The separation between the groups seems to be weaker at the heel and weakest at the toeball. The results may indicate that monitoring of the skin impedance spectrum may be a method for detection of skin changes associated with DPN, encouraging further studies with the big toe sensor in particular.
Development of a small footprint device for measuring electrodermal activity in the palm of the hand
Authors: Aukrust Åsmund , Foseid Leah Marie , Holm Kristiane
Published: January 2023

This paper describes the proof of concept for a wearable device that measures skin conductance, to provide a way of quantifying an individual’s physiological stress response to external stimuli. Important goals of the project were to have reliable measurements that correlate with the external stimuli, as well as a small footprint and low power consumption to facilitate battery powered operation.

These goals were accomplished using a STM32L476 micro-controller to generate an AC sine voltage across two solid gel electrodes placed in the palm of the hand, converting the resulting current to a voltage with a trans-impedance amplifier, which was then sampled and processed digitally in a lock-in amplifier, to eliminate signals differing from the desired (reference) frequency and phase. The output of the lock-in amplifier represents the skin conductance and was transmitted over USB to a computer with software for serial capture.
اتحاد الصناعات العراقي 1956 -1983 دراسة تاريخية اقتصادية
Authors: ABBAS SALAH ORAIBI
Published: January 2023

على اثر التطور الصناعي الكبير في فترة الخمسينيات من القرن العشرين في العراق اصبحت الحاجة ملحة لا يجاد  مؤسسة تضم اصحاب المشاريع الصناعية لتمكينهم من مواصلة المسيرة الصناعية ، وتكون حلقة وصل بينهم وبين الحكومة وتعمل على حماية الصناعة الوطنية، لذلك تم تأسيس اتحاد الصناعات العراقي في الثاني من حزيران عام 1956 وفق قانون اتحاد الصناعات المرقم (52) ، وقد عمل الاتحاد منذ تأسيسه وحتى دمجه عام 1983 مع الاتحاد العام لغرف التجارة العراقية على تنشيط الصناعة الوطنية وتذليل العقبات التي تعترض طريقها ، وذلك عن طريق اتباع عدة أساليب منها ارسال البرقيات والمذكرات والتواصل مع الجهات الحكومية ، وعقد لقاءات مع الصناعيين والتجار ، وعقد الندوات والمؤتمرات المحلية ، واستقبال الوفود القادمة للعراق ، والمشاركة في المؤتمرات الخارجية والمعارض من أجل توثيق علاقات العراق الاقتصادية مع الدول العربية وبقية دول العالم ، وكذلك اصدار التقارير الصناعية والمسوحات ودليل الصناعات العراقية ، واصدار مجلة تعنى بالشؤون الصناعية ، وكتابة البحوث والدراسات التي تسلط الضوء على الواقع الصناعي وكيفية النهوض به .
A Discourse Analysis of Interactions with Alexa Virtual Assistant Showing Reproductions of Gender Bias
Authors:   Universidade Tecnológica Federal do Parana (Brasil), Oliveira Christiane Burle de , Amaral Marilia Abrahão ,   Universidade Tecnológica Federal do Parana (Brasil)
Published: January 2023

Virtual assistants are everywhere, and most of these artifacts come by default with a female name and voice. This article refers to Science, Technology and Society (STS) studies to analyze the reproduction of gender bias in the discourse of Alexa virtual assistant, making use of the French Discourse Analysis method. From the interaction with Alexa and comparison of its responses with those found in previous surveys, it is identified the discursive and ideological formations in such speech, aiming to find stereotypic patterns. By working on the identification of unconscious gender biases in the discourse, approaching HumanComputer Interaction, this study presents how the prejudice-laden patriarchal culture presents itself in mediation with technology. By analyzing the assistant’s answers to genderrelated interactions, an awareness can be developed to help with a strategy of technological solutions that adjust this experience and create a less harmful and more inclusive design
Puleo, Alicia H. Ser feministas. Pensamiento y acción. Editorial Cátedra, 2020. 280 pp. ISBN: 978-84-9134-630-2
Authors:   Universidad de La Laguna (España), Cabrera Castro Paula
Published: January 2023

Review of the monographic volume Ser feministas. Pensamiento y acción published in the Cátedra publishing house in 2020. This work aims to be a basic guide to key concepts and elements for feminism. It is constituted as a kind of dictionary of terms and slogans and slogans relevant to the feminist movement.
The Syntax of Genesis 1:1–3
Authors: Holmstedt Robert
Published: January 2023

It is well known that Gen 1:1–3 contains considerably more linguistic complexity than readers may initially notice. As the first verses in the Hebrew Bible, they have engendered significant theological and scholarly analysis and been caught up in the modern “creation-science” debate. Yet, for all this attention, the linguistic details are often overlooked or, in some cases, disregarded in favour of ideologically-bound analyses that preference tradition over plain grammatical sense. In this essay, I address two basic linguistic issues methodically: (1) the grammar of the first orthographic word, bereshit, and its implications for the syntactic analysis of verse 1, and (2) the syntactic analysis of verse 2. I conclude that there are only two linguistically plausible analyses of Gen 1:1–3, neither of which matches the traditional rendering “In the beginning, God created ... ”.
Emigracja a proces uczenia się małżonków
Authors: Kupis Karolina , Kalus Alicja Maria , Mazurek Emilia
Published: January 2023

Wstąpienie Polski do struktur Unii Europejskiej zapoczątkowało emigrację poakcesyjną Polaków, dla której charakterystyczne było pojawienie się nowych kierunków wyjazdów emigracyjnych. Jednym z najbardziej popularnych stała się Wielka Brytania. Wyjazd emigracyjny jest wydarzeniem znaczącym w biografii człowieka i całej jego rodziny. W świetle koncepcji Agnieszki Bron (2000, 2006), wiąże się on z licznymi napięciami, ambiwalencją, poczuciem bezradności i zawieszenia (tzw. floating), a jednocześnie jest wydarzeniem o potencjale edukacyjnym. Celem badań uczyniono wyjaśnienie procesu uczenia się małżonków doświadczających emigracji. Przeprowadzono badania biograficzne z wykorzystaniem autobiograficznego wywiadu narracyjnego i analizy dokumentów osobistych. W badaniach wzięło udział 10 diad małżeńskich przebywających na emigracji długookresowej w Wielkiej Brytanii. W wyniku analizy materiału empirycznego wyróżniono następujące kategorie doświadczeń wpisujące się we floating: zaskoczenie zastaną rzeczywistością, poczucie zagubienia i osamotnienia, niepewność co do słuszności podjętej decyzji, utrata poczucia bezpieczeństwa, podejmowanie prób radzenia sobie z kryzysem, wybór strategii radzenia sobie i uczenia się. Jednak nie w każdej narracji autobiograficznej występują wszystkie z wyróżnionych kategorii. W porównaniu z koncepcją A. Bron struktura floating w badanych biografiach składa się z większej liczby elementów, a jednocześnie traci swą etapowość, staje się rozmyta, ma charakter mozaikowy. Zidentyfikowano także dziesięć strategii radzenia sobie z poczuciem zawieszenia, nisko bądź wysoko zorientowanych na jedną z kultur: kraju przyjmującego lub kraju macierzystego. Strategie te w większości sprzyjały poznawaniu nowej kultury. Natomiast samo uczenie się od początku pobytu na emigracji było postrzegane jako wartość sprzyjająca adaptacji do życia w nowych uwarunkowaniach społeczno-kulturowych.
Mechanical thrombectomy for acute paradoxical cerebral embolism due to pulmonary arteriovenous malformation: A case report and review of literature
Authors: Inoue Satoshi , Fujita Atsushi , Kurihara Eiji , Sasayama Takashi
Published: January 2023

Background:

We report a case of acute occlusion of the middle cerebral artery (MCA) due to pulmonary arteriovenous malformation (PAVM), for which mechanical thrombectomy was performed and a good outcome was achieved.

Case Description:

A 59-year-old woman presented with severe right hemiplegia and dysarthria, and a National Institutes of Health Stroke Scale (NIHSS) score of 10. Magnetic resonance imaging (MRI) diffusion-weighted imaging revealed high-signal areas in the left lenticular nucleus to the corona radiata, and right temporal lobe. Magnetic resonance angiography revealed the left MCA occlusion. Chest plain computed tomography (CT) revealed PAVM in the lower lobe of the left lung. Transvenous thrombolytic therapy was started 2 h after onset, and mechanical cerebral thrombectomy was performed with an aspiration catheter and stent retriever. A red thrombus was retrieved in one pass and complete recanalization was achieved. After treatment, her symptoms improved markedly, but a symptomatic intracerebral hematoma was observed in the contralateral right temporal lobe. The patient underwent embolization for PAVM on day 24 and was transferred for rehabilitation (NIHSS score = 2).

Conclusion:

Although rare, PAVM is a treatable cause of stroke in relatively young adults; thus, it is important to keep in mind the possibility of its presence.