bluuebunny/crossref_metadata_2025 huggingface dataset:
Sub-acute and long-term effects of ayahuasca on mental health and well-being in healthy ceremony attendants: A replication study
Authors: van Oorsouw Kim I. , Uthaug Malin V. , Mason Natasha L. , Broers Nick J. , Ramaekers Johannes G.
Published: August 2021

Background and aims

There is a growing body of evidence suggesting that the psychedelic plant tea, ayahuasca, holds therapeutic potential. Uthaug et al. (2018) demonstrated that a single dose of ayahuasca improved mental health sub-acutely and 4-weeks post-ceremony in healthy participants. The present study aimed to replicate and extend these findings. A first objective was to assess the sub-acute and long-term effects of ayahuasca on mental health and well-being in first-time and experienced users. A second aim was to extend the assessment of altered states of consciousness and how they relate to changes in mental health.

Method

Ayahuasca ceremony attendants (N = 73) were assessed before, the day after, and four weeks following the ceremony.

Results

We replicated the reduction in self-reported stress 4-weeks post ceremony, but, in contrast, found no reduction in depression. Also, increased satisfaction with life and awareness the day after the ceremony, and its return to baseline 4 weeks later, were replicated. New findings were: reduced ratings of anxiety and somatization, and increased levels of non-judging 4-weeks post-ceremony. We replicated the relation between altered states of consciousness (e.g., experienced ego dissolution during the ceremony) and mental health outcomes sub-acutely. The effects of ayahuasca did not differ between experienced and first-time users.

Conclusion

Partly in line with previous findings, ayahuasca produces long-term improvements in affect in non-clinical users. Furthermore, sub-acute mental health ratings are related to the intensity of the psychedelic experience. Although findings replicate and highlight the therapeutic potential of ayahuasca, this needs to be confirmed in placebo-controlled studies.
Bribery and Control in Stable Marriage
Authors: Boehmer Niclas , Bredereck Robert , Heeger Klaus , Niedermeier Rolf
Published: August 2021

We initiate the study of external manipulations in Stable Marriage by considering  several manipulative actions as well as several manipulation goals. For instance, one goal  is to make sure that a given pair of agents is matched in a stable solution, and this may be  achieved by the manipulative action of reordering some agents' preference lists. We present  a comprehensive study of the computational complexity of all problems arising in this way.  We find several polynomial-time solvable cases as well as NP-hard ones. For the NP-hard  cases, focusing on the natural parameter "budget" (that is, the number of manipulative  actions one is allowed to perform), we also conduct a parameterized complexity analysis  and encounter mostly parameterized hardness results.
Todesspritze, Massenimpfung und Welterneuerung: Fantastische Störästhetik und therapeutische Utopie in Constanze Dennigs Dramen und Romanen (am Beispiel von Exstasy Rave, Klonküsse und Die rote Engelin)
Authors: Coelsch-Foisner Sabine
Published: August 2021

This paper explores central generic and anthropological aspects of Constanze Dennig’s prose and drama in terms of their »disruptive aesthetic«, which is non-mimetic and disrupts all things familiar: logic, perception, morals and narrative patterns. To this end, I shall focus on three exemplary works: her play Exstasy Rave (2003) and her two novels Die rote Engelin, Eros, Omam und ich (2002) and Klonküsse (2005). Exstasy Rave, which was a huge success on and beyond Austrian stages, deals with the challenges of an aging society and its implications for the individual. Die rote Engelin, Eros, Omam und ich (The Red Angel, Eros, Omam and Me) is about a woman who is abandoned by her husband and embarks on a fantastic feminist journey of emancipation, which culminates in world power, betrayal and death by murder. Klonküsse (Clone Kisses) is about a female scientist and her cloned daughter who pursue a revolutionary project of freeing humanity from emotions through mass vaccination. As Dennig’s heroines both succeed and fail in their rebellion against social constraints and power structures that delimit their individual freedoms, the disruptive aesthetic of her texts serves a fundamental critique of whatever forces discriminate against, inhibit or stunt individual lives. The power of her absurdist-macabre texts lies not in offering trumped-up solutions, but in revealing what she calls the »unlived moments of life«. Being both a writer and a practising psychiatrist, she considers these – ultimately therapeutic – fancies far more interesting than people's actual life-stories.  
Covid-19 Pandemisi Sürecinde Seyahatten Kaçınma Niyetinin Karmaşıklık Bakış Açısı ile Analizi
Authors: ÇİZEL Beykan , KIRTIL İsmail Gökay , ÇİZEL Rabia , AŞKUN Volkan
Published: August 2021

Kriz ve afet dönemleri gibi, sistemlerin olağan dinamiklerinden uzaklaştığı ve kaotik örüntüler sergilediği süreçlerde turistlerin seyahat niyetlerinde farklılıklar ortaya çıkabilmektedir. Bu çalışmanın amacı, Covid-19 gibi yüksek risk ve belirsizlik içeren bir dönemde yerli turistlerin seyahatten kaçınma niyetini karmaşıklık teorisi bakış açısıyla bir model içerisinde incelemektir. Araştırmanın çalışma grubunda çevrimiçi anket vasıtasıyla ulaşılan 349 yerli turist yer almıştır. Veri toplama için kullanılan soru formunda demografik sorular hariç, toplam beş değişken yer almış ve her bir değişken üç soruyla ölçülmüştür. Bulanık küme nitel karşılaştırmalı analiz (fsQCA) yoluyla araştırma değişkenleri arasındaki asimetrik ilişkiler yedi konfigürasyon altında incelenmiştir. Bu konfigürasyonların farklı yaş, cinsiyet, eğitim düzeyi, medeni hal durumlarında ve farklı koşul değişkenleri bağlamında sonuç değişkeni üzerinde ne tür etkileri olduğu tartışılmıştır. Buna göre, pandemi sürecindeki hijyen ve ekonomik kaygıların turistlerin seyahatten kaçınma niyetini etkilediği saptanmıştır.
İyi Öğretmen Ölçeğinin Türk Kültürüne Uyarlanması Çalışması
Authors: ILTER İlhan
Published: August 2021

Bu araştırmada Devine, Fahie ve McGillicuddy (2013) tarafından geliştirilen “İyi Öğretmen Ölçeği”nin Türk kültürüne uyarlanması amaçlamıştır. Bu amaçla çalışmanın verileri bir yükseköğretim kurumunun eğitim fakültesinin farklı bölümlerinde öğrenim gören 350 öğrenciden elde edilmiştir. Araştırmada ilk olarak orijinal ölçek uzman görüşleri doğrultusunda dil ve kültürel açıdan Türkçeye uyarlanmış ve ölçeğin dilsel eşdeğerliği sağlanmıştır. Daha sonra ölçeğin yapı geçerliği çalışmaları için birinci ve ikinci düzey doğrulayıcı faktör analizleri yapılmıştır. Ölçeğin güvenirlik çalışmaları için ise Cronbach Alfa iç tutarlık katsayısı hesaplanmıştır. Birinci ve ikinci düzey DFA sonuçları birlikte değerlendirildiğinde ölçeğin orijinal formunda yer alan beş faktörlü yapının araştırmanın örneklem grubu üzerinde doğrulandığı görülmüştür. Ölçeğin faktörleri “Öğretme ve öğrenme tutkusu”, “Sosyal ve ahlaki boyut”, “Yansıtıcı uygulayıcı”, “Öğrenmeyi etkili planlama ve yönetme” ve “Çocuklara/gençlere sevgi” şeklindedir. Ölçeğin bütünü için hesaplanan Cronbach Alfa iç tutarlık katsayısının .86 olduğu; ölçekteki faktörler için hesaplanan iç tutarlık katsayılarının ise .77 ile .82 arasında değiştiği bulunmuştur. Araştırmanın bulguları, Türk kültürüne uyarlanan İyi Öğretmen Ölçeği’nin öğretmen adaylarının iyi öğretmen özellikleri hakkındaki farkındalık düzeylerini ölçmede geçerli ve güvenilir bir ölçme aracı olduğunu göstermektedir.
Tasarım Odaklı Düşünme Yaklaşımı Aracılığıyla Sosyal Bilgiler Dersine Yönelik Geliştirilen Ürünlerin Etkililiği
Authors: AYDEMİR Arcan , ÇETİN Turhan
Published: August 2021

Ürün geliştirmede sıkça kullanılan tasarım odaklı düşünme yaklaşımı özellikle eğitim-öğretim ortamlarında sorun veya eksikliklerin belirlenmesi ve giderilmesinde çok önemlidir. Tasarım odaklı düşünme sürecinde geliştirilen ürünlerin etkililiğine odaklanan bu çalışmada hem nitel hem de nicel yöntem kullanılarak, kullanılan ürünlerin akademik başarıya etkisi ve sürece yönelik görüşlerin ortaya çıkarılması amaçlanmıştır. Araştırmanın nicel boyutunda deney-kontrol gruplu deneysel desen, nitel boyutunda ise olgubilim (fenomenoloji) kullanılmıştır. Araştırmanın çalışma grubunu ortaokul 6.sınıfta öğrenim gören öğrenciler oluşturmaktadır. Araştırmada elde edilen veriler “Elektronik Yüzyıl” başarı testi ve yarı yapılandırılmış görüşme formu kullanılmıştır. Araştırmada elde edilen nitel veriler içerik analizi, nicel veriler ise Mann Whitney u ile Wilcoxon İşaretli Sıralar testleri kullanılarak analiz edilmiştir. Araştırma sonucunda tasarım odaklı düşünme aracılığıyla tasarlanan ürünlerle gerçekleştirilen süreç sonucunda elde edilen puanların, programın ön gördüğü şekilde gerçekleştirilen süreç sonunda elde edilen puanlara göre istatistiki olarak anlamlı bir şekilde farklılaştığına ulaşılmıştır. Buna ek olarak deneysel işlemin uygulandığı öğrenci grubu ise süreci, kolay öğrenme sağlaması, derste oyunların kullanılması, dersin eğlenceli hale gelmesi şeklinde değerlendirmişlerdir.
Derslik Dışı Fen Etkinliklerinin Öğretmen Adayları Üzerindeki Etkileri: Bir Eylem Araştırması
Authors: ATMACA Sevilay
Published: August 2021

Özellikleri nedeniyle Fen eğitiminin sınıfta yapılabilecek etkinliklerinin derslik dışı etkinliklerle desteklenmesi büyük önem taşımaktadır. Bu çalışmada derslik dışı fen etkinliklerine (DDFE) yönelik öğretim programı, Eğitim Fakültesi öğrencilerinden bir gruba uygulanmış̧ ve öğretmen adayları üzerindeki etkilerine bakılmıştır. Araştırma yöntemi olarak “eylem araştırması yöntemi” benimsenmiştir ve toplanan nitel veriler “yöntem çeşitlemesi” yoluyla elde edilmiştir. Araştırmanın problemi farklı yerlerdeki (botanik park, bilim merkezi ve hayvanat bahçesi) sınıf dışı etkinliklerin öğretmen adayları üzerindeki etkilerinin ortaya çıkarılmasıdır. DDFE uygulaması boyunca öğretmen adaylarına ilişkin gözlemler ve görüşmeler yapılmış̧, dokümanlar toplanmıştır. İçerik analizi ve betimsel analiz için endüktif (inductive) analiz NVivo 9 Programı yardımıyla kullanılmıştır. Verilerden elde edilen dört ana tema: Ggezi öncesi”, “Gezi sırası”, “Gezi sonrası” ve “Fen Bilimleri eğitimine katkılar” olarak belirlenmiştir. Sonuç olarak, DDFE dersini aldıktan sonra öğretmen adayları sınıf dışı fen eğitimi etkinliklerine profesyonel ve ciddi bir boyut getirmişlerdir. Araştırmanın problemi “öğretmen adaylarına açık alan/doğal ortamlarda (Botanik Parkı), bilim merkezlerinde (Feza Gürsey Bilim Merkezi), müzelerde (Atatürk Orman Çiftliği Hayvanat Bahçesi) verilen DDFE ve bu alanlardaki uygulamaların öğretmen adayları üzerindeki yansımaları nelerdir?” olarak belirlenmiştir. DDFE uygulaması boyunca öğretmen adaylarına ilişkin gözlemler ve görüşmeler yapılmış̧, dokümanlar toplanmıştır. İçerik analizi ve betimsel analiz için endüktif (inductive) analiz kullanılmıştır. Verilerden elde edilen dört ana tema, “gezi öncesi”, “gezi sırası”, “gezi sonrası” ve “fen ve teknoloji eğitimine katkılar” olarak belirlenmiştir. Sonuç olarak, DDFE dersini aldıktan sonra öğretmen adaylarının konuyu profesyonel bir bakış̧ açısıyla daha ciddiye aldıkları, kuramsal anlamda ve uygulama konusunda yetersizliklerini tamamlayarak alanda yeni uygulamalar tasarlayabilecek duruma geldikleri söylenebilir.
Review of problem-solving measurement: an assessment developed in the Indonesian context
Authors: WİCAKSONO Azizul Ghofar Candra , KOROM Erzsébet
Published: August 2021

The accuracy of learning results relies on the evaluation and assessment. The learning goals, including problem solving ability must be aligned with the valid standardized measurement tools. The study on exploring the nature of problem-solving, framework, and assessment in the Indonesian context will make contributions to problem solving assessment in Indonesian educational learning system. This review involved 32 studies that focus on problem-solving test development conducted in Indonesia and have the Indonesian version of the test. All tests are in the scope of certain subjects (mathematics, science, physics, and chemistry) and administered grade 7 to undergraduate level. Each test revealed a good value of reliability. Most of them have acceptable reliability score (r-value between .60 and .80) and high-reliability score (r > .80). Besides, they also showed content and construct validity (acceptable r value in Pearson product moment analysis and INFIT MNSQ index), but additional analysis is needed to fully develop the tests’ empirical evidence. All the tests are categorized as domain specific problem solving which focus on mathematics, science for junior high school, physics, chemistry, and biology. In addition, the topic coverage in the test should be improved and further studies about the measurement of problem-solving and test development are needed in the case of the Indonesian context.
Ultrasound guided rectus sheath block to reduce oral analgesic requirement after ambulatory laparoscopic tubal resection v1
Authors: not provided oomaliwa
Published: August 2021

A prospective, randomized controlled, superiority trial was conducted among patients who had been scheduled for ambulatory laparoscopic tubal resection between September 2015 and January 2019 at tertiary care hospitalin southern Thailand. Anesthesia was induced following protocol. The intervention group was allocated to receive a rectus sheath block after intubation. All patients received a multimodal analgesia regimen as follows: fentanyl and ketorolac intraoperatively and fentanyl and oral acetaminophen at the post-anesthetic care unit. Postoperative time to first analgesic requirement, oral analgesia (acetaminophen/ibuprofen) and pain score at 6 and 24 hours were accessed via telephone interviews.Patients and accessor were blinded to the study intervention. Percentage, effect size (ES) and 95% confidence interval (CI) were presented.
From Home to Community: Reflecting Emotions Related to Mobility
Authors: Holmberg Suvi , Räsänen Jenni-Mari
Published: August 2021

This study investigates how clients’ emotions are invoked and reflected in client–worker interactions and themeanings they have regarding leaving home. We concentrate on floating support work, which aims to support people suffering from mental health and substance abuse‐related issues to improve their living in the community. Our theoretical framework is based on the geography of emotions, and we draw on both the interactional and relational approaches thereto. The research material is gathered from Finland and England. We draw on mobile ethnographic and discursive approaches, and our data consists of transcriptions and field notes gathered during floating support visits (N = 19) that took place either at or outside of a client’s home. Our findings demonstrate how the connections between places and emotions, the emotions connected to leaving one’s home, the emotions reflected while being out in the community, and the reflections of emotions after being out in the community are constructed and reflected in client–worker interactions. The study highlights that these emotions are a necessary and demanding part of promoting clients’ social inclusion in the context of floating support work.
Generalized Topp-Leone-Weibull AFT Modelling: A Bayesian Analysis with MCMC Tools using R and Stan
Authors: Ashraf-Ul-Alam Md. , Khan Athar Ali
Published: August 2021

The generalized Topp-Leone-Weibull (GTL-W) distribution is a generalization of Weibull distribution which is obtained by using generalized Topp-Leone (GTL) distribution as a generator and considering Weibull distribution as a baseline distribution. Weibull distribution is a widely used survival model that has monotone- increasing or decreasing hazard. But it cannot accommodate bathtub shaped and unimodal shaped hazards. As a survival model, GTL-W distribution is more flexible than the Weibull distribution to accommodate different types of hazards. The present study aims at fitting GTL-W model as an accelerated failure time (AFT) model to censored survival data under Bayesian setting using R and Stan languages. The GTL-W AFT model is compared with its sub-model and the baseline model. The Bayesian model selection criteria LOOIC and WAIC are applied to select the best model.
Analysis of slotted waveguide antenna array excited by tuning screws
Authors:   , Azar Tony Joseph , Coren Richard L.
Published: August 2021

A radiating array consisting of Longitudinal, centered slots, excited by objects inside the waveguide have several advantages that makes it attractive for the broadcast industry. This dissertation analyses a waveguide with a slot in the center of its broad wall, excited by a tuning screw. The waveguide can be made to radiate at different channels and with different elevation patterns. Parameters of the analysis are post position and penetration and slot position and length. We present a Method of Moments analysis of such a unit element, consisting of screw and slot, and of two unit elements, including their mutual coupling. Also, a fast and accurate analysis of a truncated post is presented. The results are presented in the form of scattering matrices and the data are compared to the widely used finite element code HFSS. The post/slot combination is shown to be equivalent to a shunt element on a transmission line. In comparison with all available commercial software, it is found that our Method of Moments code is fast, accurate and efficient. It requires only normally available hardware and runs in a matter of minutes. The complete radiation pattern of an eight element array is shown.
Histologi, Histomorfometri, dan Histokimia Hati Ayam Buras (Gallus gallus domesticus) Selama Periode Sebelum dan Setelah Menetas
Authors: Siswandy Siswandy , Rahmi Erdiansyah , Masyitha Dian , Fitriani Fitriani , Gani Fadli A. , Zuhrawaty Zuhrawaty , Akmal Muslim
Published: August 2021

ABSTRAK. Hati adalah kelenjar terbesar yang terdapat di dalam tubuh dan dapat dianggap sebagai organ pusat dalam pemeliharaan suplai energi. Penelitian ini bertujuan untuk mengetahui histologi, histomorfometri, dan histokimia sebaran glikogen pada hati ayam buras sebelum dan sesudah menetas. Sampel penelitian dibagi menjadi empat kelompok tingkat umur berbeda dan masing-masing kelompok berjumlah enam hati ayam. Hasil penelitian menunjukkan perbedaan nyata (P0,05) pertumbuhan hati ayam buras secara makroskopis. Pada setiap perkembangan sudah terdapat hepatosit berbentuk poligon yang memiliki inti sel bulat di tengah hepatosit, terdapat juga vena central yang dilapisi sel endotel pipih selapis serta didapati sinusoid yang berada diantara hepatosit, dan juga ditemukan Kupffer’s cell hanya pada hati ayam setelah menetas hari ke-7. Hasil pengukuran diameter vena central hati ayam buras hari ke-7, hari ke-14, hari ke- 20 sebelum menetas dan hari ke-7 setelah menetas berturut-turut adalah 17,70 ± 1,16 µm; 60,32 ± 2,22 µm; 49,316 ± 1,93 µm; dan 129,11 ± 7,43 µm. Hasil histokimia sebaran glikogen pada hati ayam buras hari ke-14, hari ke- 20 sebelum menetas dan hari ke-7 setelah menetas berturut-turut adalah 1,44 ± 0,93; 2,27 ± 0,74; dan 2,77 ± 0,15. Dapat disimpulkan, bahwa diameter vena central dan sebaran glikogen meningkat seiring pertumbuhan ayam buras. (Histological, histomorphometrical, and histochemical of liver on native chicken (Gallus gallus domesticus) during pre and posthatch period) ABSTRACT. The liver is the largest gland in the body and considered as a central organ in maintaining energy supplies. The study aimed to determine the histologic, histomorphometric and histochemical of glycogen distribution in the liver of native chicken during pre and posthatching period.. The study sample were divided into four different age groups and each group consisted of six chicken livers. The results showed a significant difference (P0,05) in native chicken liver growth macroscopically. In every development there are already polygonal hepatocytes that have a round cell nucleus in the middle of the hepatocytes, there is also a central vein that is coated with a layer of flat endothelial cells and also sinusoids that are between the hepatocytes, and kupffer's cells also found in chicken liver 7th day posthatching. The results measurements of the central vein diameter in liver native chickens on the 7th, 14th, 20th pre hatching period and 7th post hatching were 17.70 ± 1.16 µm; 60.32 ± 2.22 µm; 49.32 ± 1.93 µm; and 129.11 ± 7,43 µm; The measure results of the glycogen distribution in liver native chickens on the 14th, 20th pre hatching period and 7th post hatching were 1,44 ± 0,93; 2,27 ± 0,74; and 2,77 ± 0,15. It can be concluded, that central vein diameter and glycogen distribution were increased by growth of native chickens.
Histologis Perkembangan Embrio Ayam pada Masa Inkubasi Satu sampai Tujuh Hari
Authors: Fitriani Fitriani , Husmimi Husmimi , Masyitha Dian , Akmal Muslim
Published: August 2021

ABSTRAK. Penelitian ini bertujuan melihat perkembangan embrio ayam secara histologi pada waktu 1, 2, 3, 4, 5, dan 7 hari inkubasi. Sampel yang digunakan adalah telur fertil yang didapat dari teaching farm Fakultas Pertanian Jurusan Peternakan Universitas Syiah Kuala. Pengamatan secara makroskopis dilakukan pada setiap sampel embrio ayam, sementara pengamatan mikroskopis struktur embrio ayam dilakukan dengan pembuatan preparat histologi. Hasil penelitian ini menampilkan data perkembangan embrio ayam secara spesifik dari umur inkubasi hari ke-1 sampai hari ke-7. Secara makroskopik dan mikroskopis, gambaran umum perkembangan embrio ayam selaras dengan informasi tabel pertumbuhan embrio ayam. Secara histologis, gambaran perkembangan struktur embrio ayam baru dapat diamati dengan baik yaitu pada umur inkubasi hari ke-3 sampai hari ke-7. Dapat disimpulkan bahwa secara histologi perkembangan embrio ayam baru dapat diamati pada masa inkubasi hari ke-3. Penelitian ini juga dapat dijadikan sebagai bahan acuan dasar untuk penelitian lanjutan terutama terhadap organogenesis pada embrio ayam.  (Histological evaluation on the development of chicken embryo during the incubation periodfrom 1st to 7th days) ABSTRACT. The aim of this study was to find out the development of chicken embryos at day 1st, 2nd, 3rd, 4th, 5th, and 7th of incubation by histological method. The samples used were the fertile eggs obtained from the teaching farm of the Faculty of Agriculture, Department of Animal Husbandry, Syiah Kuala University. Macroscopic observations were made on each embryos sample, while microscopic observations of the embryos structure were carried out by histological preparations procedure. The results of this study presented the specific data of chicken embryos development from day 1st to day 7th of incubation. The macroscopic and microscopic data showed the general description of chicken embryos development similar to the information on the chicken embryo growth table. The microscopic results showed the structure description of the chicken embryos can be well observed at day 3rd to the day 7th of incubation. It can be seen the development of chicken embryos can be observed by histology method on day 3rd of incubation. This research can also be used as a basic reference for further research, especially on organogenesis of chicken embryos.
Effects of Using Fermented Moringa (Moringa oleifera) Leaf Meal and Yellow Corn in the Diets on the Performances and Income Over Feed Cost of the Broiler Chickens
Authors: Zulfan Zulfan , Zulfikar Zulfikar , Latif Herawati , Allaily Allaily , Nazarullah Taufik , Shaleha Rhaudatul
Published: August 2021

ABSTRAK. Recently, exploring unconventional feedstuffs were not merely interested at the point of lower cost, but also natural sources and supporting bird health have been noticing on the critical assessments by poultry nutritionists to serve well broiler meat. This study aimed to examine the effect of including fermented moringa leaf meal (fMOL) + yellow corn (yC) to substitute fractionally commercial diet (CD) on the performances and Income over Feed Cost (IOFC) of the broiler chickens. The study was done in the Field Laboratory of Animal Husbandry, Animal Husbandry Department, Syiah Kuala University from August 4 until September 15, 2020. The study used 100 broiler chicks strain CP 707, unsex. This study was set up into Block Randomized Design (BRD) consisting of 4 treatments and 5 blocks. The treatments were MC0 = 100% CD, MC1= 95% CD + 2,5% fMOL + 2,5% yC, MC2= 90% CDR + 5% fMOL + 5% yC, and MC3= 85% CD + 7,5% fMOL + 7,5% yC. The results of studies showed that including fMOL + yC to substitute partly commercial diet significantly (P0.05) reduced final body weight (FBW) and increased feed conversion ratio (FCR) of the broilers. Feed consumption statistically was not significantly affected but tended to reduce. Using fMOL + yC reduced feed cost but revenue and IOFC also declined. (Pengaruh penggunaan campuran daun kelor dan jagung terhadap performan dan IOFC ayam broiler) ABSTRACT. Tujuan penelitian ini adalah untuk melihat pengaruh penggunaan tepung daun kelor fermentasi (TKF) ditambah dengan jagung kuning (JK) sebagai pengganti sebagian ransum komersil (RK) terhadap performan ayam broiler. Penelitian ini dilakukan di Laboratorium Lapangan Peternakan, Fakultas Pertanian Universitas Syiah Kuala, Banda Aceh. Materi yang digunakan adalah 100 ekor DOC ayam broiler strain CP 707. Ransum perlakuan adalah MC0= RK 100%, MC1= 95% RK + 2,5% TKF + 2,5% JK, MC2= 90% RK + 5% TKF + 5% JK, dan MC3= 85% RK + 7,5% TKF + 7,5% JK. Rancangan yang digunakan adalah Rancangan Acak Kelompok (RAK) terdiri dari 4 perlakuan dan 5 kelompok. Pengelompokan didasarkan pada berat badan ayam pada awal minggu ketiga. Parameter yang diamati meliputi berat badan akhir, konsumsi dan konversi ransum, dan Income Over Feed and Cost (IOFC), Hasil penelitian memperlihatkan bahwa penggunaan TKF + JK sebagai substitusi sebagian ransum komersil nyata (P0,05) menurunkan berat badan akhir dan meningkatkan konversi ransum. Konsumsi ransum tidak nyata berpengaruh, namun cenderung menurun. Pengunaan daun kelor menurunkan biaya ransum, dan IOFC.
Construir una iglesia (Vom Bau der Kirche) SCHWARZ, Rudolf
Authors: Fernández-Cobián Esteban
Published: August 2021

Este libro se escribió en la hora más oscura de Alemania, pero por primera vez arroja luz sobre la cuestión de la construcción de iglesias e ilumina todo el problema de la arquitectura en sí mismo. Rudolf Schwarz, el gran constructor de iglesias alemán, es uno de los pensadores más profundos de nuestro tiempo. Su libro, a pesar de su claridad, no es fácil de leer, pero quien se tome la molestia de estudiarlo con detenimiento obtendrá una visión real de los problemas discutidos
Breast Cancer Treatment and Antibody Drug Conjugates: Beyond T-DM1
Authors: Ung Mony , Lacaze Jean , Maio Eleonora , Dalenc Florence
Published: August 2021

Antibody–drug conjugates (ADCs) are a new class of anticancer agents that combine cytotoxic agents attached by a linker to a monoclonal antibody. These engineered drugs can selectively deliver a cytotoxic payload to targeted cancer cells and the local microenvironment (bystander effect), thereby increasing activity and reducing off-target toxicity. The association of ADCs with other anti-cancer therapies is therefore promising. Trastuzumab-emtansine was the first approved ADC in breast cancer (BC), specifically for the management of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. New ADCs are in development in BC. Some have shown meaningful clinical benefit and have been recently approved, such as trastuzumab deruxtecan in HER2-positive trastuzumab emtansine (T-DM1) pretreated BC and Trop-2 guided sacituzumab govitecan in triple-negative BC. Trastuzumab deruxtecan also has potential clinical activity in HER2-low BC thanks to a bystander effect. In this article, we review the ADCs under development in advanced BC.
Impacts of Transportation Emissions on the Risk of Mortality: Findings from the Literature and Policy Implications
Authors: Nadafianshahamabadi Razieh , Tayarani Mohammad , Gao H.
Published: August 2021

Introduction: Externalities from transportation, and in particular exposure to vehicle emissions have been considered a possible cause of several negative health outcomes including mortality. However, the existing findings are too inconsistent to drive a well-founded exposure-response function to be fully exploited to curb the negative impacts of transportation systems on public health. In this study, we investigate the association between exposure to air pollution and mortality. We then evaluate how using different air quality methods may result in detecting different health outcomes. Methods: We conduct an analysis of reviewing a representative sample of main published studies that specifically focused on the association between vehicle air pollution and mortality. Results: Our study finds that vehicle air pollution may increase the risk of mortality through a slightly high association. Most importantly, the risk of overall mortality increases by 5% per 10 µg/m3 increase in NO2 concentration, 2% per unit of traffic intensity on the road, and 7% per unit of distance closer to the road. Conclusion: The findings imply the role of exposure to vehicle emissions in increasing the risk of mortality. The method used to detect the health outcomes can alter the health finding from positive to null or vice versa and even extensively affect the analysis outcomes. The results suggest the need for establishing indicators to benchmark the performance of air quality methods and emphasize the necessity to integrate public health measures into the urban and transportation planning process.
Doctor-patient relationship and public trust in health science in post-COVID world: Lessons from USA and India
Authors: Saha Kunal
Published: August 2021

Building better trust between doctors and patients is key to improving the standard of healthcare delivery system in rich and poor countries alike. Trust between doctors and patients depends on a variety of ill-defined factors that include physician behavior, skill, cost of healthcare and societal perception of integrity of the medical community. Mode of practice of medicine has undergone radical changes during the COVID-19 pandemic with frequent use of PPE and long-distance video consultancy. COVID-19 pandemic has caused enormous pain, suffering and death across the globe. While many morbidities and mortalities due to COVID-19 were inevitable, gross medical mismanagements of COVID-19 have also contributed to increased rate of death of COVID-19 patients in many countries. Most importantly, shocking political intrusion of medical science during the COVID-19 pandemic has caused unprecedented erosion of public trust in the medical profession in several countries, particularly in USA and India. Top medical leaders in the Center for Disease Control (CDC) and Food and Drug Administration (FDA) in USA, the “gold standard” medical authorities, stood speechless next to the USA president, Donald Trump, as he brazenly made numerous false, unscientific and dangerous claims to prevent and cure COVID-19. Top government healthcare authorities in India also spread misinformation and baseless claims about COVID-19 morbidities and mortalities to misguide ordinary people. While some devious medical leaders shamelessly supported the bogus claims under sinister pressure from their political leaders, other doctors around the world made tremendous selfless sacrifice and stepped forward to save the victims of COVID-19 even at the risks to their own lives. Although there is little doubt that experience during the COVID-19 pandemic may have significant impact on public trust in the medical profession in the future, whether doctor-patient relationship will improve or deteriorate in the post-COVID world remains uncertain at this juncture. But it is imperative that the medical community must send a strong and clear message now disparaging any exploitation of the scientific evidence on COVID-19 pandemic in fear of any political or medical retribution.
Comparison of post-dural puncture headache incidence among patients undergoing spinal anaesthesia for elective caesarean section by using quincke 25-G and 29-G spinal needles
Authors: Omer Tahreem , Anwar Anum , Ahmed Hina Nabi , Khan Mohammad Harris , Barlas Maaz , Zia Ashraf
Published: August 2021

Background: Multiple complications including hypotension, nausea, vomiting, urinary retention, transient neurological symptoms and headache have been associated with spinal anaesthesia. Importantly, post dural puncture headache (PDPH) varies with the type and size of spinal needle employed for inducing anaesthesia. Here, we aimed to compare the frequency of PDPH in patients underwent spinal anaesthesia for elective caesarean section using 25-gauge (G) and 29-G Quincke spinal needle.Methods: We designed a randomized control trial at Obstetrics and Gynecology Operation Theatres, Jinnah Hospital, Lahore. A total of 152 patients having age 30.28±8.21 years were enrolled in the study and divided into two groups each comprising of 76 patients. In group 1, spinal anaesthesia was performed using 25-G Quincke spinal needle while in group 2 spinal anaesthesia was administered employing 29-G Quincke spinal needle. A standard dose of 10.5-12.0 mg (1.4-1.6 ml) of 0.75% bupivacaine is infiltrated in subarachnoid space at lumber region L3-L4 or L4-L5 following aseptic measures. The patients were evaluated for PDPH during the follow up period.Results: The previous history of PDPH was observed in 20.39% patients. The comparative study showed that the PDPH was observed in 12 (15.7%) patients in group 1 while the group 2 revealed PDPH in only 2 (2.6%) patients.Conclusions: Thus 29-G spinal needle can be regarded as a better option to reduce PDPH in patients subjected to spinal anaesthesia for elective cesarean in contrast to the use of 25-G Quincke spinal needle.
Mucormycosis: a rare but rising fungal infection in COVID-19 patients at tertiary care centre
Authors: Samale Anuja A. , Rathod Vimal S. , More Sanjaykumar R. , Gujrathi Atish B.
Published: August 2021

Background: New pandemic Coronavirus disease 2019 (COVID-19) shows wide range of disease pattern from mild to life threatening pneumonia in association with bacterial and fungal infections. Invasive fungal infections are becoming new burden in COVID-19 patients especially when associated with diabetes mellitus.Methods: We have studied 90 patients of invasive fungal sinusitis at tertiary care centre over a period of 3 months from March 2021 to June 2021 prospectively. All patients suspected for invasive fungal sinusitis in association with covid19 are included. Results: 67 males and 23 females of age group 41 to 70 years were presented as case of invasive fungal sinusitis with suspicion of Mucormycosis. Disease extended to orbit in 90 patients, to hard palate in 33 and skin involved in 5 patients. Diagnosis based on clinical presentation, computed tomography (CT scan) findings, KOH preparation and culture. KOH showing fungal elements in 62 patients and fungi isolated in 37 patients. Aspergillus group and mucorales contribute equally being found in 17 samples each. 23 patients lost their life due to this disease. This study is done and reported first time from this tertiary care centre.Conclusions: Invasive fugal sinusitis including Mucormycosis otherwise rare disease has significantly increased in COVID-19 pandemic. Immune dysregulation due to COVID-19, Diabetis mellitus and wide spread use of corticosteroids/antibiotics all contributed to this rise in cases of invasive fungal diseases. Early diagnosis, surgical intervention and antifungal treatment help to reduce mortality and morbidity.
Vitamin C supplementation as adjuvant analgesic therapy in post-operative pain management in patients undergoing surgical decompression in a case of prolapsed intervertebral disc
Authors: Mahajan Neetin P. , Narvekar Mrugank A. , Chandanwale Ajay S. , Gadod Lalkar L. , Prasannakumar G. S.
Published: August 2021

Background: The management of postoperative pain has been a major challenge for the operating surgeons. Vitamin C has shown analgesic effects in specific clinical conditions, reducing patient suffering and improving the quality of life. The objective of this study was to evaluate the efficacy of vitamin C as an adjuvant in postoperative pain management and its effect on analgesia requirements in patients undergoing spinal decompression surgery.Methods: The present study was a prospective study of 50 patients aged 30-60 years with low back pain due to prolapsed intervertebral disc requiring surgical decompression, conducted in a tertiary care institute from 2018 to 2020. All patients underwent open discectomy. 25 patients each were randomized into two groups, those that were given vitamin c supplementation (group A) and those that weren't (group B). The patients were then followed up 1st, 2nd, 4th, and 6th week and the pain was graded at each follow-up according to the NRS scale. The total amount of diclofenac sodium consumed in the 6 weeks was calculated.Results: The mean NRS (A vs B) at 2 (2.68 vs 3.56) and 4 (0.88 vs 1.48) weeks follow-up showed a statistically significant difference between the two groups, but the difference was not significant at 6 (0.16 vs 0.36) weeks follow up. The difference in the consumption of analgesic (3.56 vs 5.46) at 6 weeks was statistically significant.Conclusions: In this clinical outcome-based study, we suggest that for postoperative pain management, vitamin C acts as an efficacious adjuvant with a dose-sparing effect on the consumption of analgesics.
Clinical profile and risk factors associated in patients of mucormycosis in COVID-19 pandemic: a study in a tertiary centre
Authors: Anas M. , Choudhary R. K. , Alam Noman
Published: August 2021

Background: The objective of this study was to determine the clinical profile and risk factors associated in patients of mucormycosis in COVID-19 pandemic.Methods: It was a prospective observational study conducted at a tertiary care centre in the month of May and June 2021. It involved all patients of mucormycosis mainly involving paranasal sinuses and orbit. The clinical profile and associated risk factors leading to mucormycosis were studied.Results: Thirty patients of mucormycosis mean age 56.62 years out of them 25 (83.33%) male and 5 (16.66%) female were studied. Twenty-four patients (80%) had COVID-19 infection, out of them 7 (29.2%) were active and 17 (70.8%) had recovered within 4 weeks. Five (16.6%) patients were suspected as they had symptoms of COVID-19 previously   but never got tested. One   patient had no history of COVID infection. All the patients were diabetic at the time of presentation, out of them 26 (86.6%) of patients were known diabetic and 4 (13.3%) became diabetic after COVID-19 infection. The ethmoids were the most common sinuses affected. Intra-orbital extension was seen in 13 (43.3%) of cases   while intracranial extension was seen in 4 (13.3%) patients. Twenty-eight (93.3%) patients gave history of steroids intake. Antibiotics were taken by 76.6% patients while zinc supplement was used by 83.3% patients. Oxygen was used 10 (33.3%) patients, 80% of them using face mask or canula and 4 of them requiring mechanical ventilatory support.  Conclusions: The risk factors associated with mucormycosis in COVID pandemic must be given serious consideration as there is sudden increase in the case and mortality is very high. Uncontrolled diabetes and over use of steroids in COVID management are two main aggravating factors, however other factors must also be studied thoroughly.
Surgical treatment of congenital malenocytic nevus of cheek in adult: an interesting case report
Authors: Gupta Madhusoodan , Varshney Deepti
Published: August 2021

Congenital melanocytic nevus (CMN) is a rare disease, which is present from birth. CMN has pigmented surface and hairs. CMN are classified in three types according to their size, small size less than 2 cm, medium size 2-20 cm and large or giant size more than 20 cm. If CMN is present over the cheek it causes significant aesthetic deformity. It poses a great challenge to aesthetic and reconstruction surgeon to excise and reconstruct this lesion over the cheek. Cheek is central facial unit and make the largest part of face. Here author presents a case of 20 years old young female who had medium size congenital melanocytic nevi over the left cheek at malar aesthetic subunit. Author planned a single stage excision followed by primary closure. Wound healed well without any complication and sutureline was camouflaged in left nasolabial crease with good aesthetic result.
COVID-19 and Indian frontline workers
Authors: Chaudhary Ankit , . Priyanka , Chamotra Shaina
Published: August 2021

The pandemic of COVID-19 has posed challenges and revealed so many shortcomings in vision and execution of health system. Despite of threats, it has also given ample opportunities for improvement in health care delivery. Health professional of each category has contributed beyond their capability in curbing the pandemic. Frontline workers like health workers and accredited social health activist (ASHA) workers have worked at the grass root level and given their absolute best despite their already stringent work schedule and job profile. Already trusted with so many health programs and community activities, they have excelled in management of the pandemic. However, this has posed a serious question and threat to already burdened health system. The pandemic has further worsened already compromised plight of frontline health personnel. It is high time that appropriate consideration be given to such workers in order to improve health system. Some form of appreciation in terms of monetary benefits, some administrative commendation or welfare measures must be thought to recognize their sincere efforts.
Prevalence of low back pain and associated factors among office workers in Kano city, Nigeria
Authors: Salihu Muhammad Nuhu , Lawal Mamman Muhammad , Musa Abuhuraira Ado , Abdullahi Yusuf Muhammad , Umar Maryam Dahiru , Amaka Oruche Chinyere , Addi Jacob Jonah , Muhammad Faisal
Published: August 2021

Background: Many studies across the globe have reported the prevalence of low back pain (LBP) among office workers. This study aimed to find out the prevalence of LBP and associated factors among office workers in Kano city, Nigeria.

Methods: A cross-sectional type of study was conducted among the office workers in Kano metropolitan from September to December 2019. A total of 300 office workers were selected using a convenience sampling technique. The data was collected from the respondents by face-to-face interview technique using a semi-structured questionnaire and all the data collected were analyzed using statistical software (SPSS version 22.0).

Results: In this study, the mean age of the respondents was 38.6±9.6 years and 72.7% of them were male. More than half (54.7%) of the respondents had a bachelor's degree and above. About 71.3% of the respondents had a familial history of LBP. About 68.0% of the respondents had suffered musculoskeletal disorder in the past and the majority (54.4%) mentioned they suffered hip pain. Only 33.7% of the respondents were maintaining the proper posture and 37.7% of the respondents were using an ergonomic chair.

Conclusions: The findings of this study found a 65.3% prevalence of low back pain among the office workers in Kano metropolitan. Office workers should be encouraged to maintain proper postures at work and there is a need for more educational programs regarding the prevention measures of low back pain.
Nora’s lesion: bizarre parosteal osteochondromatous proliferation in right foot: a case report
Authors: Yadav Shikhar , G. Divya , Mohan Jithin , Varghese Joice
Published: August 2021

Nora’s lesion is a benign lesion involving mainly the proximal phalanges, metatarsals or metacarpals in the hands and feet. It may be easily confused with a malignant entity and was first identified and reported by Nora et al. in 1983. We present a case of a 12 years old female with complains of a swelling over the right foot noticed 4 months ago. Plain radiograph revealed heterotrophic calcification over the dorso-lateral aspect of the head of the first metatarsal. MRI scan of the foot was suggestive of a benign pathology with a differential of bizarre parosteal osteochondromatous proliferation (BPOP) or an osteochondroma. The patient was managed with excision biopsy and lesion was excised along with the pseudo-capsule and adjoining periosteum. Cortex appeared normal and wound was washed with hydrogen peroxide and incision closed. Histopathology report was suggestive of Nora’s lesion. One year follow up of the patient showed no recurrence. BPOP proliferation is a benign lesion however differentials need to be kept in mind and treatment with excision of the lesion along with the pseudo-capsule and periosteal tissue beneath the lesion has low rates of recurrence.
An invitro study of synergetic effect of Vitamin C on antimicrobial activity of antibiotics against isolated from respiratory samples
Authors: Nasimuddin Sowmya , Malaiyan Jeevan , Kandasamy Mohanakrishnan , J Nithyalakshmi , M Kamalraj , G Sumathi
Published: August 2021

Vitamins are essential for various biological responses such as immune function and gene expression in humans. The infections of respiratory tract with is quite common throughout the world. Vitamin C supplements reduces the duration and symptoms of the respiratory infections shown by few therapeutic trials. This study was undertaken to find out whether Vitamin C has got any effect upon the sensitivity pattern of antibacterial prescribed for isolated from respiratory samples using disc diffusion method in vitro. In our study, by using student T test analysis, Vitamin C significantly decreased the inhibition zone of antibiotics Ciprofloxacin (40%), Imipenem (72%) indicating a decrease in their antibacterial effect invitro. Also, Vitamin C enhanced the antibacterial effect of Doxycycline (64%) and Ceftazidime-Clavulanic acid (36%) significantly. Significant decrease in zone diameter was observed on addition of Vitamin C to antibiotics, Imipenem (56%), Ciprofloxacin (40%). It is to be noted that effect of Vitamin C on Ceftazidime-Clavulanic acid is both increase and decrease in zone diameter which were also statistically significant. This might be due to small sample size of isolates (Number – 50) undertaken in the study. The observations noted in this study need further development in terms of increased number of isolates and proper standardization of Vitamin concentrations, with respect to each antibiotic. Being an invitro study, it does not establish any chemical interactions between Vitamins and antibiotics and needs further research by clinical methods.

: The interaction of Vitamin C on antibacterial against common respiratory pathogens needs further exploration in the area of research as they show interesting results when studied invitro under a small sample size.
Mid upper arm circumference in pregnant women and its relationship with birth weight
Authors: Nath Soren Surendra , Sarathi Sahu Partha
Published: August 2021

: Mid upper arm circumference (MUAC) is considered as a good indicator of maternal nutritional status in pregnant women. Very few studies have been done to establish a relationship between MUAC and birth weight of newborn. This study was carried out to analyze the relationship between MUAC and birth weight of newborn in a tertiary health care facility.

This cross sectional study was conducted in 240term pregnant women. MUAC was measured to the nearest millimeters using a non-stretchable tape at the midpoint between acromian process and olecranon process. Newborn baby weight was measured within 24 hrs of birth. The association between MUAC and birth weight was established by linear regression analysis.

The mean of MUAC among pregnant women delivering LBW was 21.68±2.27 cm which was significantly low (p<0.001) compared to women delivering normal babies (23.47±2.56 cm). There wasa positive correlation(r=0.32;p<0.05)between MUAC and birth weight of newborn.The cut off value of MUAC for the prediction of LBW in our study was found to be 22.59 cm with 62.77% sensitivity and 71.55% specificity.

Among the various maternal factors for the prediction of LBW, mid-upper arm circumference (MUAC) can be correlated with birth weight outcome effectively.