bluuebunny/crossref_metadata_2025 huggingface dataset:
Albert Katthoff Ein Bremer Pastor im Übergangsfeld von linkem Reform-Protestantismus und freigeistiger Bewegung
Authors: Auwärter Thomas
Published: December 2009

The religious history of Bremen includes many impressive figures. Probably the most enigmatic figure of Bremen's church life around 1900 was the pastor at St. Martini, Albert Kalthoff (1850-1906). However, his impact reached beyond the borders of local religious history: He was important for the history of the Protestant culture of piety as well as for a religious historical analysis of reform attempts within Protestantism in Imperial Germany. Kalthoff was part of the leftist reform movement within German Protestantism. Furthermore, he can be said to have had certain sympathies for the free thinker movement. This article wants to situate Kalthoff and his public works and goals in religious history with regard to the religious-confessional, cultural-religious, and cultural-political tendencies of his time. His example delineates the contours of a transitional space between Protestantism and the free thinker movement.
Feminist Theology: Where is it Going?
Authors: Ruether Rosemary Radford
Published: December 2009

This article explores five stages of the development of feminist theology as a public theology. Starting with feminist theology in liberal Protestant seminaries in the US, it shows its development as multi-ethnic theology, then as international theology, including the third world, then as an interfaith theology and finally through transnational feminism. The article concludes with some suggestions about new horizons for feminist theology as a public theology in 2009.
Catholicism, Choice and Consciousness: A Feminist Theological Perspective on Abortion
Authors: Beattie Tina
Published: December 2009

Despite the apparently irreconcilable conflict between ‘pro-life’ and ‘pro-choice’ activists in the abortion debate, many feminists and Catholic theologians agree that questions of consciousness, relationality and foetal development are of greater ethical significance than theological claims about the personhood of the embryo or feminist claims about women’s autonomy. This article argues that absolutist positions based on the embryo’s right to life or the woman’s right to choose fail to represent the reality of abortion and the dilemmas it poses. It suggests an approach in which maternal consciousness and foetal development are together recognized as intrinsic to the process of humanization, and argues for a gradual shift in emphasis from the primacy of the woman’s right to choose in the first trimester, to the right to life of the foetus in the third semester. It concludes with a reflection on Mary and Eve, as symbols of women’s eschatological hope and existential reality with regard to childbearing.
Social representations of history, wars and politics in Latin America, Europe and Africa
Authors: Techio Elza , Bobowik Magdalena , Páez Darío , Cabecinhas Rosa , Liu James , Zubieta Elena , Espinosa Agustín
Published: December 2009

This study analyzes how people perceive world history on three continents: Latin America, Europe and Africa. A total of 1179 university students form Argentina, Brazil, Peru, Portugal, Spain, Guinea-Bissau, and Cape Verde were asked to evaluate world events and leaders in terms of their valence and importance. The results demonstrated that social representations of history show a Euro/North American-centric, long-term positive evaluation, recency, and socio-centric bias. Euro/North American-centric events and leaders were found to be rated as more important and were more positively perceived in general. Distant political events, like French or American Revolution, were considered to be more positive than XX century similar events, which supports the long-term positive evaluation bias hypothesis. The hypothesis on recency bias was partially substantiated. Confirming the existence of such bias, World War II was rated as more important than the previous XX century wars and revolutions. Socio-centric bias also received partial support. African participants rated Mandela as a more important leader than other participants did. Latin Americans rated Che Guevara less positively, which suggests that some leaders are generally idealized icons, not based on group belongingness. However, results did not bring support to the centrality of war hypothesis. Wars were indeed negatively evaluated and World War II was rated as an important and negative event. Nevertheless, war- and politics-related events were not perceived as more important than the Industrial Revolution, suggesting that people appraise the importance of long-term socioeconomic factors of history when responding to close-ended quantitative measures (vs. open-ended salience measures). Results are discussed in the framework of social representations of history.
Official or political apologies and improvement of intergroup relations: A neo-Durkheimian approach to official apologies as rituals
Authors: Páez Darío
Published: December 2009

This article argues that institutional apologies are rituals that can be conceived from a neo-Durkheimian viewpoint as external social tools of collective emotion, which allow people to assume collective guilt and shame, increase agreement with reparatory behaviors, and reinforce social cohesion. The review of studies presented in this monograph shows that an apology reactivates and intensifies collective emotions, mainly of shame and guilt, above and beyond merely reminding people of past misdeeds, and increases support for reparation. Shame and sorrow fuel and support reparative tendencies. Finally, salience of past collective violence together with an apology improves social climate to some extent, enhances intergroup reconciliation by decreasing prejudice and improving intergroup contact, and helps to reconstruct in-group collective memory in a more critical way. Changes in collective emotions and representations of the past mediate the positive effects of apologies on reparation and social cohesion.
Effect of Reactive Hyperemia on Carotid-Radial Pulse Wave Velocity in Hypertensive Participants and Direct Comparison With Flow-Mediated Dilation: A Pilot Study
Authors: Kamran Haroon , Salciccioli Louis , Eun Hee Ko  , Qureshi Ghazanfar , Kazmi Haris , Kassotis John , Lazar Jason
Published: December 2009

This pilot study assessed the effects of hyperemia on carotid-radial pulse wave velocity (PWV) in 39 normotensive (NT) and 23 hypertensive (HT) participants using applanation tonometry. Pulse wave velocity was measured at 1- and at 2-minute intervals. Baseline PWV was similar between the groups (P = .59). At 1 minute, PWV decreased (8.5 ± 1.2 to 7.1 ± 1.4 m/s, P < .001) in NT but not in HT (P = .83). Hyperemic PWV (ΔPWV) response differed between the groups (-16% vs + 1.0%, P < .001). On multivariate analysis, HT, not age or blood pressure was independently related to ΔPWV (R2 = .43, P < .01). Among patients with cardiovascular risk factors/disease, ΔPWV was inversely related to flow-mediated dilation (FMD; R 2 = .43, P < .003). Conclusion: hyperemia decreases PWV1min in NT but not in HT. ΔPWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.
Predictors of Response to Intervention of Word Reading Fluency in Dutch
Authors: Scheltinga Femke , van der Leij Aryan , Struiksma Chris
Published: December 2009

The objective of this study was to investigate the contribution of rapid digit naming, phonological memory, letter sound naming, and orthographic knowledge to the prediction of responsiveness to a school-based, individual intervention of word reading fluency problems of 122 Dutch second and third graders whose reading scores were below the 10th percentile in comparison with the normative group. Degree of responsiveness was determined by comparison of a pre- and posttest measure of word reading fluency with a 6-month interval. At posttest, 38% of the children had improved their reading scores above the 10th percentile. Maintenance scores revealed no significant growth on average, confirming that word reading fluency skills of poor readers are hard to remediate. Except rapid digit naming, none of the measures predicted responsiveness after controlling for the autoregressive effect of initial performance on fluency of word reading. A large part of the variance remained unexplained, supporting the advantage of a response-to-intervention approach above traditional psychometric testing to identify severe reading disabilities.
Not So Fast: The (Not-Quite-Complete) Dissociation Between Accuracy and Confidence in Thin-Slice Impressions
Authors: Ames Daniel R. , Kammrath Lara K. , Suppes Alexandra , Bolger Niall
Published: December 2009

After decades of research highlighting the fallibility of first impressions, recent years have featured reports of valid impressions based on surprisingly limited information, such as photos and short videos.Yet beneath mean levels of accuracy lies tremendous variance—some snap judgments are well-founded, others wrongheaded. An essential question for perceivers, therefore, is whether and when to trust their initial intuitions about others. In three studies of first impressions based on photos and videos, the authors examined accuracy for Big Five trait judgments as well as corresponding reports of confidence. Overall, perceivers showed a limited ability to intuit which of their impressions were more accurate than others, although a curvilinear effect emerged: In the relatively few cases where perceivers reported an absolute lack of confidence, their accuracy was indeed comparatively low. Across the studies, judgment confidence was shaped by sources at the judgment level and the judge level that were unrelated to accuracy.
Capitalizing on Multiple Social Identities to Prevent Stereotype Threat: The Moderating Role of Self-Esteem
Authors: Rydell Robert J. , Boucher Kathryn L.
Published: December 2009

One troubling aspect of membership in a stigmatized group is that negative stereotypes about the group’s performance affect one’s personal performance (i.e., stereotype threat). Women who are made aware of the negative stereotype that “women are bad at math” perform worse than women who are not made aware of this stereotype. However, women can use an “escape hatch” to avoid stereotype threat by identifying with another social identity (i.e., college students) that has positive stereotypes for math performance and having greater feelings of self-worth. This research shows that women who had greater self-esteem and were presented with an alternative, positive social identity were buffered from stereotype threat by eliminating working memory decrements responsible for poor math performance. Women lower in self-esteem, however, did not benefit from a positive, alternative social identity when it was available and thus fell prey to stereotype-based working memory and performance decrements.
What Do Children Write in Science? A Study of the Genre Set in a Primary Science Classroom
Authors: Honig Sheryl
Published: December 2009

This article reports on the types of scientific writing found in two primary grade classrooms. These results are part of a larger two-year study whose purpose was to examine the development of informational writing of second- and third-grade students as they participated in integrated science-literacy instruction. The primary purpose of the present article is to report on the “genre set” (Bazerman, 2004) established in this community around science instruction. Using Halliday’s (1993) Systemic Functional Linguistics approach and Hasan’s (1985, 1994) Generic Structure Potential, I describe the genres of scientific writing and drawing activities in which these children regularly participated. Findings indicate that children participated in several distinct scientific genres, some of which were flexible, and some of which were highly constrained by the teachers. Each of the genres represented a distinct purpose, structure, and linguistic nature of scientific discourse. The influence of this particular genre set on children’s appropriation of scientific discourse is discussed.
Central System Nervous Tuberculosis in Infants
Authors: Tinsa Faten , Essaddam Leila , Fitouri Zohra , Boussetta Khadija , Ben Becher Saida , Bousnina Souad
Published: December 2009

The lack of specific symptoms and signs in patients with tuberculous meningitis makes early diagnosis difficult. In this report, we reviewed the clinical features and laboratory findings of 6 infants with central system nervous tuberculosis during a 10-year period. One of the patients had multifocal tuberculosis. The mean time to the diagnosis was 32 ± 13.4 days. A contact source was identified in only 2 patients. All 6 patients had abnormal cerebrospinal fluid findings, less than 500 cells/μL with lymphocytic predominance. Computerized tomography (CT) and/or magnetic resonance imaging (MRI) revealed hydrocephalus with basal enhancement in 2 patients. One patient developed pontocerebellar and pituitary tuberculomas, which were responsible for compression and diabetes insipidus, 1 year after antituberculous treatment. These localizations are very rare. On the follow-up, 3 patients had hypoacousia and only 1 had severe sequelae, despite a diagnostic delay.
Toward a Narrower, More Pragmatic View of Developmental Dyspraxia
Authors: Steinman Kyle J. , Mostofsky Stewart H. , Denckla Martha B.
Published: December 2009

Apraxia traditionally refers to impaired ability to carry out skilled movements in the absence of fundamental sensorimotor, language, or general cognitive impairment sufficient to preclude them. The child neurology literature includes a much broader and varied usage of the term developmental dyspraxia. It has been used to describe a wide range of motor symptoms, including clumsiness and general coordination difficulties, in various developmental disorders (including autistic spectrum disorders, developmental language disorders, and perinatal stroke). We argue for the need to restrict use of the term developmental dyspraxia to describe impaired performance of skilled gestures, recognizing that, unlike acquired adult-onset apraxia, coexisting sensory and motor problems can also be present.
Intellectual Foundations of Current Research in Family Business: An Identification and Review of 25 Influential Articles
Authors: Chrisman James J. , Kellermanns Franz W. , Chan Kam C. , Liano Kartono
Published: December 2009

This article identifies 25 articles that have been particularly influential in shaping the state of the art of research on family businesses. These works were identified based on a citation analysis of family business articles published over the past 6 years in the four journals that publish most of the research. The authors summarize those influential studies and discuss their most important contributions to scholars’ current understanding of family business. By identifying common themes among those studies, the authors are able to provide directions for future research in the field.
“Mullin’ the Yarndi” and Other Wicked Problems at a Multiracial Early Childhood Education Site in Regional Australia
Authors: Kameniar Barbara Maria , Imtoual Alia , Bradley Debra
Published: December 2009

In this article, Grint’s model of leadership is used to shape discussions of how “problems” are responded to in the context of a preschool in an Australian regional town. Authority styles are described as command, management, or leadership. These authority styles result in approaching problems as “crises,” “tame problems” or “wicked problems” and approaching racial difference in terms of computed“essentialism,” “evasion,” or “cognizance.” This article engages with the approach to “wicked problems” by arguing that framing complex issues, such as race differences, as “wicked problems” allows for multiple ways of thinking through issues which are not possible if they are framed as “crises” or “tame problems.” In this article, we examine a number of examples from the preschool of how “wicked problems” occur in daily practice.
I’m Mad and I’m Bad
Authors: Mouttapa Michele , Watson Donnie W. , McCuller William Jason , Sussman Steve , Weiss Jie W. , Reiber Chris , Lewis Deanna , Tsai Winnie
Published: December 2009

This preliminary study examined whether anger and identification with the ‘‘gang member’’ peer group are associated with heavy alcohol use. Participants were 91 (53.8% male) juvenile offenders in four juvenile probation camps in Southern California who completed a self-report survey. More than half (53.4%) indicated that they best fit in with the ‘‘gang member’’ peer group. In a multivariate model, identification with the ‘‘gang member’’ peer group was associated with heavy alcohol use during the past 30 days prior to their incarceration. Identification with peer groups other than gang members may prevent juvenile offenders from engaging in heavy alcohol use.
Increased Utilization of Flexible Endoscopic Methods During Colorectal Resection Over a 3-Year Period
Authors: DiMaggio Vincent , Hoffman Keith , Baxter Ray , Cekic Vesna , Nasar Abu , Whelan Richard L.
Published: December 2009

Introduction. Intraoperative endoscopy (IE) is performed during some colorectal resections (CRR) mainly to inspect circular stapled anastomoses (CSA) and to locate small neoplasms. This study’s purpose was to determine how often rigid and flexible lower endoscopic methods were used during CRR by one colorectal surgeon over three 1-year periods. Methods. Data concerning the indication for surgery and IE, type of resection, and the use of rigid and flexible methods were obtained from a prospective database and from hospital charts during Period 1 (P1), 1/1/05 to 12/31/05; P2, 7/1/06 to 6/31/07; and P3, 7/01/07 to 6/30/08. The endoscopic CO2 insufflation device was introduced during P2. The utilization rates (UR) for rigid and flexible methods and the overall UR in each time period were compared. The χ2 and Fisher exact test were used for analysis. Results. No significant differences were found in overall endoscopy UR between periods (94-109/per period.) A significantly higher flexible UR was noted during P3 (43.1% of all CRR) than during P1 (18.6%, P < .001) or P2 (28.7%, P < .03). There was a concomitant significant drop in the rigid UR during Period 3 (1.8% of all CRR) when compared with P1 (24.5%, P < .001) or P2 (27.7%, P < .001). Conclusion. The overall UR did not significantly vary; however, during P3 the flexible UR increased whereas the rigid UR decreased (vs P1, P2; P < .05). The addition of extra endoscopes and an endoscopic CO2 insufflation device to the operating room coincided with increased flexible UR.
Surgical Abdominal Wall (SAW): A Novel Simulator for Training in Ventral Hernia Repair
Authors: Seagull F. Jacob , George Ivan , Ghaderi Iman , Vaillancourt Marilou , Park Adrian
Published: December 2009

Laparoscopic ventral hernia repair (LVHR) is a relatively common procedure that requires advanced minimally invasive surgical skills to perform. The role for simulation is increasingly supported as an effective way to teach surgical skills and accelerate the learning curve. This article describes The University of Maryland’s Surgical Abdominal Wall, an inexpensive procedure-specific physical simulator for LVHR, and summarizes the authors’ early experiences using this model in a curriculum for surgery residents.
Long-term results following osteotomy of the thumb delta phalanx in Rubinstein–Taybi Syndrome
Authors: Jain A. , Rehman S. , Smith G.
Published: December 2009

Rubinstein–Taybi Syndrome is a rare condition affecting 1:125,000 children. It is associated with short broad radially deviated thumbs, secondary to a delta proximal phalanx of the thumb. We undertook a retrospective review of seven children (13 thumbs) with Rubinstein–Taybi syndrome whose thumbs were treated using a corrective osteotomy to the delta phalanx over a 13 year period. The types of osteotomy used in the series were reverse wedge osteotomy, opening wedge osteotomy and dome shaped osteotomy. The mean preoperative radial deviation of thumbs was 68° (range 45–85°). At follow up five of the 13 thumbs demonstrated some residual radial deviation. All recurrences occurred in the dome shaped osteotomy group. Our data suggest that surgery is effective in correcting the deformity, but there is a risk of incomplete correction or recurrence. Despite the recurrence the mean postoperative deformity was significantly better than preoperatively and the majority of patients families subjectively reported good function. No patient in our series has yet undergone further corrective surgery.
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
Authors: Morales-Tirado Vanessa , Sojka Dorothy K. , Katzman Shoshana D. , Lazarski Christopher A. , Finkelman Fred D. , Urban Joseph F. , Fowell Deborah J.
Published: December 2009

Patients with Wiskott-Aldrich syndrome (WAS) have numerous immune cell deficiencies, but it remains unclear how abnormalities in individual cell types contribute to the pathologies of WAS. In T cells, the WAS protein (WASp) regulates actin polymerization and transcription, and plays a role in the dynamics of the immunologic synapse. To examine how these events influence CD4 function, we isolated the WASp deficiency to CD4+ T cells by adoptive transfer into wild-type mice to study T-cell priming and effector function. WAS−/− CD4+ T cells mediated protective T-helper 1 (Th1) responses to Leishmania major in vivo, but were unable to support Th2 immunity to Nippostrongylus brasiliensis or L major. Mechanistically, WASp was not required for Th2 programming but was required for Th2 effector function. WAS−/− CD4+ T cells up-regulated IL-4 and GATA3 mRNA and secreted IL-4 protein during Th2 differentiation. In contrast, cytokine transcription was uncoupled from protein production in WAS−/− Th2-primed effectors. WAS−/− Th2s failed to produce IL-4 protein on restimulation despite elevated IL-4/GATA3 mRNA. Moreover, dominant-negative WASp expression in WT effector T cells blocked IL-4 production, but had no effect on IFNγ. Thus WASp plays a selective, posttranscriptional role in Th2 effector function.
Using patient and physician perspectives to develop a shared decision-making framework for colorectal cancer
Authors: Leon-Carlyle Marisa , Spiegle Gillian , Schmocker Selina , Gagliardi Anna , Urbach David , Kennedy Erin
Published: December 2009

Background

Colorectal cancer is the third leading cause of death from cancer worldwide with over 900,000 diagnoses and 639,000 deaths each year. Although shared decision making is broadly advocated as a mechanism by which to achieve patient-centred care, there has been little investigation of patient and physician shared decision-making preferences and practices or the outcomes associated with shared decision making in the context of colorectal cancer.

Aim

The aim of this study is to determine patient and physician attitudes towards the use of shared decision making in the setting of colorectal cancer.

Methods

Standard principles of qualitative research will be used to sample and interview 20 colorectal cancer patients in each of three tertiary care hospitals (n = 60) and 15 surgeons, radiation oncologists, and medical oncologists (n = 45) affiliated with cancer centres. The interview questions will be guided by a conceptual framework defining patient and physician factors that influence the shared decision-making process and associated outcomes in the setting of colorectal cancer. An inductive, grounded approach will be used by two investigators to independently analyze the interview transcripts. These investigators will meet to compare and achieve consensus on themes that will be tabulated to compare barriers, enablers, and outcomes of shared decision making by patient, physician, and contextual factors.

Discussion

This study is the first to examine both patient and physician perspectives on the use of shared decision making for colorectal cancer in North America or elsewhere. It will provide a framework that can be used to describe the shared decision-making process and its outcomes, and evaluate strategies to facilitate this process for patients with colorectal cancer.
Postmenopausal estrogen and progestin effects on the serum proteome
Authors: Pitteri Sharon J , Hanash Samir M , Aragaki Aaron , Amon Lynn M , Chen Lin , Busald Buson Tina , Paczesny Sophie , Katayama Hiroyuki , Wang Hong , Johnson Melissa M , Zhang Qing , McIntosh Martin , Wang Pei , Kooperberg Charles , Rossouw Jacques E , Jackson Rebecca D , Manson JoAnn E , Hsia Judith , Liu Simin , Martin Lisa , Prentice Ross L
Published: December 2009

Background

Women's Health Initiative randomized trials of postmenopausal hormone therapy reported intervention effects on several clinical outcomes, with some important differences between estrogen alone and estrogen plus progestin. The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated.

Methods

Baseline serum samples were compared with samples drawn 1 year later for 50 women assigned to active hormone therapy in both the estrogen-plus-progestin and estrogen-alone randomized trials, by applying an in-depth proteomic discovery platform to serum pools from 10 women per pool.

Results

In total, 378 proteins were quantified in two or more of the 10 pooled serum comparisons, by using strict identification criteria. Of these, 169 (44.7%) showed evidence (nominal P < 0.05) of change in concentration between baseline and 1 year for one or both of estrogen-plus-progestin and estrogen-alone groups. Quantitative changes were highly correlated between the two hormone-therapy preparations. A total of 98 proteins had false discovery rates < 0.05 for change with estrogen plus progestin, compared with 94 for estrogen alone. Of these, 84 had false discovery rates <0.05 for both preparations. The observed changes included multiple proteins relevant to coagulation, inflammation, immune response, metabolism, cell adhesion, growth factors, and osteogenesis. Evidence of differential changes also was noted between the hormone preparations, with the strongest evidence in growth factor and inflammation pathways.

Conclusions

Serum proteomic analyses yielded a large number of proteins similarly affected by estrogen plus progestin and by estrogen alone and identified some proteins and pathways that appear to be differentially affected between the two hormone preparations; this may explain their distinct clinical effects.
The Follistatin-288 Isoform Alone Is Sufficient for Survival But Not for Normal Fertility in Mice
Authors: Kimura Fuminori , Sidis Yisrael , Bonomi Lara , Xia Yin , Schneyer Alan
Published: December 2009

Follistatin (FST) is a natural antagonist of activin and related TGFβ superfamily ligands that exists as three protein isoforms differing in length at the C terminus. The longest FST315 isoform is found in the circulation, whereas the shortest FST288 isoform is typically found in or on cells and tissues, and the intermediate FST303 isoform is found in gonads. We recently demonstrated that the FST isoforms have distinct biological actions in vitro that, taken together with the differential distribution, suggests they may also have different roles in vivo. To explore the specific role of individual FST isoforms, we created a single-isoform FST288-only mouse. In contrast to the neonatal death of FST global knockout mice, FST288-only mice survive to adulthood. Although they appear normal, FST288-only mice have fertility defects including reduced litter size and frequency. Follicles were counted in ovaries from 8.5- to 400-d-old females. Significantly fewer morphologically healthy antral follicles were found in 100- to 250-d FST288-only ovaries, but there were significantly more secondary, primary, and primordial follicles detected at d 8.5 in FST288-only ovaries. However, depletion of this primordial follicle pool is more rapid in FST288-only females resulting in a deficit by 250 d of age and early cessation of reproduction. Superovulated FST288-only females have fewer ovulated eggs and embryos. These results indicate that the FST isoforms have different activities in vivo, that the FST288-only isoform is sufficient for development, and that loss of FST303 and FST315 isoforms results in fertility defects that resemble activin hyperactivity and premature ovarian failure.
Refined convergence for the Boolean model
Authors: Calka Pierre , Michel Julien , Paroux Katy
Published: December 2009

In Michel and Paroux (2003) the authors proposed a new proof of a well-known convergence result for the scaled elementary connected vacant component in the high intensity Boolean model towards the Crofton cell of the Poisson hyperplane process (see, e.g. Hall (1985)). In this paper we investigate the second-order term in this convergence when the two-dimensional Boolean model and the Poisson line process are coupled on the same probability space. We consider the particular case where the grains are discs with random radii. A precise coupling between the Boolean model and the Poisson line process is first established. A result of directional convergence in distribution for the difference of the two sets involved is then derived. Eventually, we show the convergence of the process, measuring the difference between the two random sets, once rescaled, as a function of the direction.
Likelihood-based inference for Matérn type-III repulsive point processes
Authors: Huber Mark L. , Wolpert Robert L.
Published: December 2009

In a repulsive point process, points act as if they are repelling one another, leading to underdispersed configurations when compared to a standard Poisson point process. Such models are useful when competition for resources exists, as in the locations of towns and trees. Bertil Matérn introduced three models for repulsive point processes, referred to as types I, II, and III. Matérn used types I and II, and regarded type III as intractable. In this paper an algorithm is developed that allows for arbitrarily accurate approximation of the likelihood for data modeled by the Matérn type-III process. This method relies on a perfect simulation method that is shown to be fast in practice, generating samples in time that grows nearly linearly in the intensity parameter of the model, while the running times for more naive methods grow exponentially.
Maximum likelihood estimation for cooperative sequential adsorption
Authors: Penrose Mathew D. , Shcherbakov Vadim
Published: December 2009

We consider a model for a time series of spatial locations, in which points are placed sequentially at random into an initially empty region of ℝd, and given the current configuration of points, the likelihood at location x for the next particle is proportional to a specified function βk of the current number (k) of points within a specified distance of x. We show that the maximum likelihood estimator of the parameters βk (assumed to be zero for k exceeding some fixed threshold) is consistent in the thermodynamic limit where the number of points grows in proportion to the size of the region.
The secretary problem of minimizing the expected rank: a simple suboptimal approach with generalizations
Authors: Krieger Abba M. , Samuel-Cahn Ester
Published: December 2009

The secretary problem for selecting one item so as to minimize its expected rank, based on observing the relative ranks only, is revisited. A simple suboptimal rule, which performs almost as well as the optimal rule, is given. The rule stops with the smallestisuch thatRi≤ic/(n+1-i) for a given constantc, whereRiis the relative rank of theith observation andnis the total number of items. This rule has added flexibility. A curtailed version thereof can be used to select an item with a given probability P, P<1. The rule can be used to select two or more items. The problem of selecting a fixed percentage, α, 0<α<1, ofn, is also treated. Numerical results are included to illustrate the findings.
Conditional percolation on one-dimensional lattices
Authors: Axelson-Fisk Marina , Häggström Olle
Published: December 2009

Conditioning independent and identically distributed bond percolation with retention parameter p on a one-dimensional periodic lattice on the event of having a bi-infinite path from -∞ to ∞ is shown to make sense, and the resulting model exhibits a Markovian structure that facilitates its analysis. Stochastic monotonicity in p turns out to fail in general for this model, but a weaker monotonicity property does hold: the average edge density is increasing in p.
Transition phenomena for ladder epochs of random walks with small negative drift
Authors: Wachtel Vitali
Published: December 2009

For a family of random walks {S(a)} satisfying E S1(a)=-a<0, we consider ladder epochs τ(a)=min {k≥1: Sk(a)<0}. We study the asymptotic behaviour, as a⇒0, of P (τ(a)>n) in the case when n=n(a)→∞. As a consequence, we also obtain the growth rates of the moments of τ(a).
Does Waste Recycling Really Improve the Multi-Proposal Metropolis–Hastings algorithm? an Analysis Based on Control Variates
Authors: Delmas Jean-Françcois , Jourdain Benjamin
Published: December 2009

The waste-recycling Monte Carlo (WRMC) algorithm introduced by physicists is a modification of the (multi-proposal) Metropolis–Hastings algorithm, which makes use of all the proposals in the empirical mean, whereas the standard (multi-proposal) Metropolis–Hastings algorithm uses only the accepted proposals. In this paper we extend the WRMC algorithm to a general control variate technique and exhibit the optimal choice of the control variate in terms of the asymptotic variance. We also give an example which shows that, in contradiction to the intuition of physicists, the WRMC algorithm can have an asymptotic variance larger than that of the Metropolis–Hastings algorithm. However, in the particular case of the Metropolis–Hastings algorithm called the Boltzmann algorithm, we prove that the WRMC algorithm is asymptotically better than the Metropolis–Hastings algorithm. This last property is also true for the multi-proposal Metropolis–Hastings algorithm. In this last framework we consider a linear parametric generalization of WRMC, and we propose an estimator of the explicit optimal parameter using the proposals.
Systems with Failure-Dependent Lifetimes of Components
Authors: Burkschat M.
Published: December 2009

A model for describing the lifetimes of coherent systems, where the failures of components may have an impact on the lifetimes of the remaining components, is proposed. The model is motivated by the definition of sequential order statistics (cf. Kamps (1995)). Sequential order statistics describe the successive failure times in a sequential k-out-of-n system, where the distribution of the remaining components' lifetimes is allowed to change after every failure of a component. In the present paper, general component lifetimes which can be influenced by failures are considered. The ordered failure times of these components can be used to extend the concept of sequential order statistics. In particular, a definition of sequential order statistics based on exchangeable components is proposed. By utilizing the system signature (cf. Samaniego (2007)), the distribution of the lifetime of a coherent system with failure-dependent exchangeable component lifetimes is shown to be given by a mixture of the distributions of sequential order statistics. Furthermore, some results on the joint distribution of sequential order statistics based on exchangeable components are given.
On Consecutive Records in Certain Bernoulli Sequences
Authors: Holst Lars
Published: December 2009

In an infinite sequence of independent Bernoulli trials with success probabilities pk=a/(a+b +k-1) for k=1,2,3,…, let Nr be the number of r≥2 consecutive successes. Expressions for the first two moments of Nr are derived. Asymptotics of the probability of no occurrence of r consecutive successes for large r are obtained. Using an embedding in a marked Poisson process, it is indicated how the distribution of Nr can be calculated for small r.
An Inequality for Variances of the Discounted Rewards
Authors: Feinberg Eugene A. , Fei Jun
Published: December 2009

We consider the following two definitions of discounting: (i) multiplicative coefficient in front of the rewards, and (ii) probability that the process has not been stopped if the stopping time has an exponential distribution independent of the process. It is well known that the expected total discounted rewards corresponding to these definitions are the same. In this note we show that, the variance of the total discounted rewards is smaller for the first definition than for the second definition.
Natural and artificial RNAs occupy the same restricted region of sequence space
Authors: Kennedy Ryan , Lladser Manuel E. , Wu Zhiyuan , Zhang Chen , Yarus Michael , De Sterck Hans , Knight Rob
Published: December 2009

Different chemical and mutational processes within genomes give rise to sequences with different compositions and perhaps different capacities for evolution. The evolution of functional RNAs may occur on a “neutral network” in which sequences with any given function can easily mutate to sequences with any other. This neutral network hypothesis is more likely if there is a particular region of composition that contains sequences that are functional in general, and if many different functions are possible within this preferred region of composition. We show that sequence preferences in active sites recovered by in vitro selection combine with biophysical folding rules to support the neutral network hypothesis. These simple active-site specifications and folding preferences obtained by artificial selection experiments recapture the previously observed purine bias and specific spread along the GC axis of naturally occurring aptamers and ribozymes isolated from organisms, although other types of RNAs, such as miRNA precursors and spliceosomal RNAs, that act primarily through complementarity to other amino acids do not share these preferences. These universal evolved sequence features are therefore intrinsic in RNA molecules that bind small-molecule targets or catalyze reactions.
Pentoxifylline added to freezing or post-thaw extenders does not improve the survival or in vitro fertilising capacity of boar spermatozoa
Authors: Gil María A , Hernandez Marta , Roca Jordi , Almiñana Carmen , Lucas Xiomara , Cuello Cristina , Vazquez Juan M , Martínez Emilio A
Published: December 2009

This study evaluated whether pentoxifylline added to freezing and thawing extenders influenced the function of boar spermatozoa. In Experiment 1, pooled ejaculated sperm-rich fractions were frozen in 0.5 ml straws after dilution in extender supplemented with pentoxifylline to a final concentration of 0, 2, 4, 8, 16 or 32 mM. The addition of 4, 8, 16 and 32 mM pentoxifylline to the freezing extender significantly decreased the progressive and total motility of spermatozoa. The percentage of viable spermatozoa with intact acrosomes as well as the penetration rate and the efficiency of fertilisation were significantly lower in pentoxifylline-treated groups compared with the untreated control. In Experiment 2, a pool of three straws with ‘good’ post-thaw sperm quality parameters and another three straws with ‘poor’ sperm quality were diluted in extender with 0, 1, 2, 4, 8, 16 or 32 mM pentoxifylline. Post-thaw samples with both ‘good’ and ‘poor’ sperm quality with 0, 2, 4, 8 and 16 mM were used to assess IVF parameters. The addition of pentoxifylline to post-thaw extender did not improve the post-thaw motility or viability of spermatozoa compared with the control. Thein vitropenetration was higher (P<0.05) than the control for oocytes fertilised with spermatozoa that were thawed and incubated in extender with 4, 8 and 16 mM pentoxifylline. However, no differences were observed in the efficiency of fertilisation. We conclude that pentoxifylline, as a supplement added to the freezing extender, has a deleterious effect and that it does not improve the survival orin vitrofertilising efficiency of frozen–thawed boar spermatozoa when added after thawing.
Transient estrogen exposure from birth affects uterine expression of developmental markers in neonatal gilts with lasting consequences in pregnant adults
Authors: Chen Joseph C , Wiley Anne A , Ho Teh-Yuan , Frankshun Amy-Lynn , Hord Kristin M , Bartol Frank F , Bagnell Carol A
Published: December 2009

Disruption of estrogen-sensitive, estrogen receptor (ER)-dependent events during porcine uterine development between birth (postnatal day=PND 0) and PND 14 affects patterns of uterine morphoregulatory gene expression in the neonate with lasting consequences for reproductive success. Uterine capacity for conceptus support is reduced in pregnant adult gilts exposed to estradiol valerate (EV) for 14 days from birth. Objectives here were to determine effects of EV exposure from birth through PND 13 on neonatal uterine and adult endometrial markers of growth, patterning, and remodeling. Targets included the relaxin receptor (RXFP1), estrogen receptor-α (ESR1) and vascular endothelial growth factor (VEGFA), morphoregulatory markers HOXA10 and WNT7A, and the matrix metalloproteinases (MMP)2 and MMP9. Gilts were treated daily with EV (50 μg/kg body weight per day, i.m.) or corn oil vehicle from birth through PND 13. Uteri were obtained from neonates on PND 14 and from adults on pregnancy day 12 (PxD 12). In neonates, EV exposure from birth increased uterineRXFP1gene expression, and both ESR1 and VEGFA proteins. At PxD 12, endometrialRXFP1mRNA remained elevated, while ESR1 protein was reduced. Early EV treatment decreased neonatal uterineWNT7A, but increasedHOXA10expression.WNT7Aexpression was reduced in EV-treated adults. Transient EV exposure increasedMMP9transcripts at PND 14, whereas both latent and active MMP9 activity was increased due to early EV treatment in adults on PxD 12. Results support the hypothesis that transient, estrogen-induced disruption of porcine uterine development from birth alters early programming events that lead to functional consequences in the adult.
Localized surface plasmon resonance sensing properties of photocatalytically prepared Ag/TiO2 films
Authors: Chang Gang , Tanahashi Ichiro , Oyama Munetaka
Published: December 2009

Photocatalytic deposition of Ag nanoparticles from a mixed aqueous solution of AgNO3 and polyvinylpyrrolidone (PVP) onto TiO2 film supported on indium-tin oxide-coated glass slide (Ag/TiO2 film) was carried out by using UV light irradiation. The size and shape of the Ag nanoparticles were controlled by the addition of PVP during the photodeposition. In the optical absorption spectra of the Ag/TiO2 film, the localized surface plasmon resonance (LSPR) absorption of the Ag nanoparticles was observed. When the film was immersed in various kinds of alcohols with the refractive index at 20°C (), ranging between 1.3292 and 1.4103, the peak LSPR absorption was shifted to longer wavelengths and the peak absorbance increased with increasing . The spectral change of the Ag/TiO2 film with larger spherical Ag nanoparticles was more prominent than that with smaller ones.
Synthesis and characterization of anatase TiO2 nanolayer coating on Ni–Cu–Zn ferrite powders for magnetic photocatalyst
Authors: Fu Yen-Pei , Chang Wen-Ku , Wang Hsin-Chao , Liu Chung-Wen , Lin Cheng-Hsiung
Published: December 2009

In the current research, we successfully prepared TiO2/Ni–Cu–Zn ferrite composite powder for magnetic photocatalyst. The core Ni–Cu–Zn ferrite powder was synthesized using the steel pickling liquor and the waste solution of electroplating as the starting materials. The shell TiO2 nanocrystal was prepared by sol-gel hydrolysis precipitation of titanium isopropoxide [Ti(OC3H7)4] on the Ni–Cu–Zn ferrite powder followed by heat treatment. From transmission electron microscopy (TEM) image, the thickness of the titania shell was found to be approximately 5 nm. The core of Ni–Cu–Zn ferrite is spherical or elliptical shape, and the particle size of the core is in the range of 70–110 nm. The magnetic Ni–Cu–Zn ferrite nanopowder is uniformly encapsulated in a titania layer forming core-shell structure of TiO2/Ni–Cu–Zn ferrite powder. The degradation efficiency for methylene blue (MB) increases with magnetic photocatalyst (TiO2/Ni–Cu–Zn ferrite powder) content. When the magnetic photocatalyst content is 0.40 g in 150 mL of MB, the photocatalytic activity reached the largest value. With a further increase in the content of magnetic photocatalyst, the degradation efficiency slightly decreased. This occurs because the ultraviolet (UV) illumination is covered by catalysts, which were suspended in the methylene blue solution and resulted in the inhibition in the photocatalytic reaction. The photocatalytic degradation result for the relationship between MB concentration and illumination revealed a pseudo first-order kinetic model of the degradation with the limiting rate constant of 1.717 mg/L·min and equilibrium adsorption constant 0.0627 L/mg. Furthermore, the Langmuir–Hinshelwood model can be used to describe the degradation reaction, which suggests that the rate-determining step is surface reaction rather than adsorption is in photocatalytic degradation.
Combinatorial doping of TiO2 with platinum (Pt), chromium (Cr), vanadium (V), and nickel (Ni) to achieve enhanced photocatalytic activity with visible light irradiation
Authors: Choi Jina , Park Hyunwoong , Hoffmann Michael R.
Published: December 2009

Titanium dioxide (TiO2) was doped with the combination of several metal ions including platinum (Pt), chromium (Cr), vanadium (V), and nickel (Ni). The doped TiO2 materials were synthesized by standard sol-gel methods with doping levels of 0.1 to 0.5 at.%. The resulting materials were characterized by x-ray diffraction (XRD), BET surface-area measurement, scanning electron microscopy (SEM), and UV-vis diffuse reflectance spectroscopy (DRS). The visible light photocatalytic activity of the codoped samples was quantified by measuring the rate of the oxidation of iodide, the rate of degradation of methylene blue (MB), and the rate of oxidation of phenol in aqueous solutions at λ > 400 nm. 0.3 at.% Pt-Cr-TiO2 and 0.3 at.% Cr-V-TiO2 showed the highest visible light photocatalytic activity with respect to MB degradation and iodide oxidation, respectively. However, none of the codoped TiO2 samples were found to have enhanced photocatalytic activity for phenol degradation when compared to their single-doped TiO2 counterparts.
The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells
Authors: Mamillapalli Ramanaiah , Wysolmerski John
Published: December 2009

The calcium-sensing receptor (CaR or CASR as listed in the MGI Database) is a G protein-coupled receptor that binds and signals in response to extracellular calcium and other polycations. It is highly expressed on parathyroid and kidney cells, where it participates in the regulation of systemic calcium homeostasis. It is also expressed on many other cell types and is involved in a wide array of biological functions such as cell growth and differentiation, ion transport, and hormone secretion. It has been described to couple to several different G proteins including Gαi/0, Gαq/11, and Gα12/13. Recently, it has also been shown to stimulate cAMP production by coupling to Gαs in immortalized or malignant breast cells. The CaR is expressed on cells in the anterior pituitary and had previously been described to stimulate cAMP production in these cells. In this report, we examined signaling from the CaR in murine pituitary corticotroph-derived, AtT-20 cells. We found that CaR activation led to the stimulation of cAMP production, and PTH-related protein (PTHrP or PTHLH as listed in the MGI Database) and ACTH secretion from these cells. Furthermore, manipulation of cAMP levels was able to modulate PTHrP and ACTH secretion independent of changes in extracellular calcium. Finally, we demonstrated that the CaR couples to Gαs in AtT-20 cells. Therefore, in pituitary corticotroph-like cells, as in breast cancer cells, the CaR utilizes Gαs and activates cAMP production to stimulate hormone secretion.