bluuebunny/crossref_metadata_2025 huggingface dataset:
Testing for Hepatitis C During Pregnancy Among Persons With Medicaid and Commercial Insurance: Cohort Study (Preprint)
Authors: Khan Mohammed A , Thompson William W , Osinubi Ademola , Meyer 3rd William A , Kaufman Harvey W , Armstrong Paige A , Foster Monique A , Nelson Noele P , Wester Carolyn
Published: July 2022

BACKGROUND

The reported incidence of acute hepatitis C virus (HCV) infection is increasing among persons of childbearing age in the United States. Infants born to pregnant persons with HCV infection are at risk for perinatal HCV acquisition. In 2020, the United States Preventive Services Task Force and Centers for Disease Control and Prevention recommended that all pregnant persons be screened during each pregnancy for hepatitis C. However, there are limited data on trends in hepatitis C testing during pregnancy.

OBJECTIVE

We estimated hepatitis C testing rates in a large cohort of patients with Medicaid and commercial insurance who gave birth during 2015-2019 and described demographic and risk-based factors associated with testing.

METHODS

Medicaid and commercial insurance claims for patients aged 15-44 years and who gave birth between 2015 and 2019 were included. Birth claims were identified using procedure and diagnosis codes for vaginal or cesarean delivery. Hepatitis C testing was defined as an insurance claim during the 42 weeks before delivery. Testing rates were calculated among patients who delivered and among the subset of patients who were continuously enrolled for 42 weeks before delivery. We also compared the timing of testing relative to delivery among patients with commercial or Medicaid insurance. Multivariable logistic regression was used to identify factors associated with testing.

RESULTS

Among 1,142,770 Medicaid patients and 1,207,132 commercially insured patients, 175,223 (15.3%) and 221,436 (18.3%) were tested for hepatitis C during pregnancy, respectively. Testing rates were 89,730 (21.8%) and 187,819 (21.9%) among continuously enrolled Medicaid and commercially insured patients, respectively. Rates increased from 2015 through 2019 among Medicaid (from 20,758/108,332, 19.2% to 13,971/52,330, 26.8%) and commercially insured patients (from 38,308/211,555, 18.1% to 39,152/139,972, 28%), respectively. Among Medicaid patients, non-Hispanic Black (odds ratio 0.73, 95% CI 0.71-0.74) and Hispanic (odds ratio 0.53, 95% CI 0.51-0.56) race or ethnicity were associated with lower odds of testing. Opioid use disorder, HIV infection, and high-risk pregnancy were associated with higher odds of testing in both Medicaid and commercially insured patients.

CONCLUSIONS

Hepatitis C testing during pregnancy increased from 2015 through 2019 among patients with Medicaid and commercial insurance, although tremendous opportunity for improvement remains. Interventions to increase testing among pregnant persons are needed.
On the Legitimacy of Exhaustion of Rights in Non-Fungible Token Transactions of Digital Works
Authors: Xia Yijing
Published: July 2022

As the golden rule of resolving the conflict between intellectual property and right in rem of the same object, exhaustion of rights aims to avoid the influence of exercising intellectual property right on right in rem. The academic circle is unable to come to any agreement concerning the discussion of extending the rule of exhaustion of rights to the regulation of utilizing works in digital conditions. The blockchain technology and market have a transformative impact on the copyrights in the digital environment. NFT and the mode of NET of digital works have reshaped the traditional ecology of online works transmission and utilization, offering opportunities for the exhaustion of rights to be applied in the network environment. Hence, it is the right moment to create the digital environment to apply the exhaustion of copyrights.
A Study on Electronic Waste Management in India
Authors: Srivastava Harshit , Wahal Harshit , Roy Hrithik , Kumar Dr. Brajesh
Published: July 2022

Abstract: In the electronic industry, e-scraps or e-wastes refer to electronic goods that are discarded or unneeded. About 50 million ton of e-wastes are produced every year. Depending on their reactions, there might be potential danger. E-wastes, such as computer batteries and other electrochemical waste, may cause unwanted results, so it is important to consider them along with physical wastes. India generates about 1.5 lakh tons of e-waste annually, and almost all of it ends up in the informal sector as there is no organized alternative. It is well documented that humanity's capabilities were enhanced by the industrial revolution. However, the revolutionary changes experience by societies across the globe due to the application of electronics are deeper and more widespread than the impact of the industrial revolution. Human society has been profoundly changed by the electronics age and has become more connected than ever before. Electronic items have contributed to smoother communication, economic growth, and job opportunities. However, in addition to the positives, technology has brought to light a number of concerns, such as the growing problem of ewaste, which society must confront head on. In the existing situation, it is always possible that human health and the environment would be in trouble. If coordinated legislation and activities for efficient e-waste management and disposal were not enacted. This paper aims to provide a quick overview of the relatively new notion of e-waste, its production in India, and the associated environmental and health implications. It emphasizes the booming informal and nascent official e-waste recycling economies, as well as the urgent need for more explicit legislation and a forward-looking strategy. The paper also examines global e-waste trading and international experience in this area. There is also a list of references at the conclusion for further reading. Each year, hundreds of thousands of consumer electronics, computers, monitors, phones, printers, televisions and other portable devices become outdated and were mainly dumped to the landfills or poorly recycled. Recent technological development and growing demands for new and better functioning electronics accelerate the amount of electronic waste (e-waste) worldwide, making it to be one of the fastest growing streams in many countries. The estimated lifespan of electronics is about three to five years because of the increasing rates of consumption, new developments and urbanization.
Web Application for Road Geometric Design
Authors: Gunjal Prof. Akash , Salave Ms. Rakhi Ajaykumar , Satpute Ms. Bhumika Vasant , Done Ms. Dhanlaxmi Balvant , Shaikh Mr.Abrar Zameer
Published: July 2022

Abstract: Transportation infrastructure includes geometric components such as horizontal, vertical curve, sight distance, super elevation, widening, and others, especially when it comes to highway amenities. The "Website for Geometric Design of Highway" project comprises a full geometric design as well as the resolution of engineers' issues in computing highway design parameters using a computer program. Geometric design elements are crucial in determining the traffic operational efficiency of a route. Traffic operations are influenced by the number and width of lanes, the width of shoulders, and the horizontal and vertical curves of the roadway
EV Charging Schemes With Different Bidirectional DC-DC Converters
Authors: Kande Saurabh S.
Published: July 2022

Abstract: In electrical vehicle, galvanic isolation for dc-dc converters are often utilized. Basically these converters are connected between your dc link and storage element. So to achieve high density in power, high efficiency with wide range of gain and bidirectional capability of power flow CLLC and Dual active bridge are most suitable for all purposes to meet. Therefore this study based on the CLLC and Dual active bridge converters. This paper also focuses on grid connected AC - DC converter and controlling DC link voltage and then collectively designing the suitable charging scheme which will be able to deliver power in both directions. The operation and control methods of these converters are explained respectively. Simulation and its findings are used to verify the correctness of the suggested notion
A Review on Hand Gesture Recognition
Authors: MA Ramanuja , Ramesh Pradyumna , Yadav Shikha , BJ Rohan , S Yashpal Gupta
Published: July 2022

Abstract: User Interface (UI) and Human Computer Interaction (HCI) have come a long way from the time computers went personal. The constant work and research done to explore HCI allows for new ways and improvements. Hand gesture recognition is part of HCI that quickly picked up after the advancements in computer hardware and machine learning, particularly computer vision. Hand gesture recognition is a natural alternative to interact with computer as compared to mechanical devices(mouse, keyboard, etc),just as we interact with other humans through hand gestures. We review the existing tools and techniques that make hand gesture possible today, along with some common pitfalls and potential fixes.
Knowledge Integrating System Using Video Mining
Authors: Rajput Monali , Umbarje Samiksha , Shinde Pranoti , Shivsharan Pranjali , Shimpi Prof Mr. A.S.
Published: July 2022

Abstract: A system will be developed in which only admin can upload videos on Cloud Server. Videos are sorted based on category and videos are automatically uploaded on Cloud Server on the schedule provided by the admin. Users can watch videos online. Users can rate videos that will be analyzed by the system. This system automatically removes videos that are less popular
Experimental Study on Influence of Bacteria in Concrete
Authors: M C Dilshad
Published: July 2022

Abstract: Concrete is a composite material composed of fine and coarse aggregate bonded together with a fluid cement (cement paste) that hardens over time. The elasticity of concrete is relatively constant at low stress levels but starts decreasing at higher stress levels as matrix cracking develop. Therefore, it is important to control the crack width and to heal the cracks as soon as possible. Since the costs involved for maintenance and repair of concrete structures are usually high, apart from conventional methods of repairing cracks with sealants or treating the concrete with adhesive chemicals to prevent the cracks from widening, a microbial crack healing approach has shown promising results and this research focuses on the development of self-healing concrete. Self-healing of cracks in concrete would contribute to a longer service life of concrete structure and would make the material not only more durable but also more sustainable
Seismic Analysis of Multistorey Floating Column Building with Lateral Load Resisting System
Authors: L Subhashini
Published: July 2022

Abstract: The primary object of the review is to know the way behaving of multistory building with floating column as for the shear wall and bracings under seismic power for various zone i.e zone 3, zone 4, zone 5. The review is done for G+7 building utilizing ETABS programming. Contrasting the outcome got in various cases and closing which kind of system provides more effectiveness
Synthesis, Purification, Identification of Aspirin and Evaluation on the Basis of Drug Release with Different Aspirin Formulation
Authors: Chakraborty Soumallya
Published: July 2022

Abstract: Aspirin is 2-acetoxy benzoic acid. It is one of the derivatives of Benzoic acid. It is white crystalline fine powder. Aspirin is acetylated product. This drug is under non-steroidal anti-inflammatory drug in which they block cyclooxygenase receptor by inhibiting COX pathway. The drug can block the production of prostaglandin derivative. Therefore they can be used as an analgesic cum antiinflammatory.
The Characteristics, Risks, Effects, and Pathophysiology of Eating Disorders -A Review of Anorexia Nervosa and Bulimia Nervosa
Authors: Johnson Karuna
Published: July 2022

Abstract: Over the past few centuries, the importance of fitness has gained prominence. Coupled with this is the idea of thinness or the need to be slender and lean as an ideal body type. Thinness and fitness are not the same but are conflated in most messages about being fit. Many individuals, especially adolescents, have been influenced by the ongoing diet culture and social media. They have an ideal body or physique and are increasingly concerned about their weight, shape, size, and body image. As an attempt to lose weight and reach their goals, individuals go to extremes and try to starve themselves and/or excessively exercise, self-induce vomiting, or misuse products like laxatives, diuretics and enemas. Starvation or other psychological discomforts can cause one to binge-eat then purge and feel satisfied for a short period of time, but it eventually leads to selfloathing. This can severely affect the individual both physically and psychologically. As this cycle continues, an eating disorder is developed. Anorexia nervosa and Bulimia nervosa are the most widely recognized, and common eating disorders. Although there is little known about the pathophysiology of eating disorders, the evidence of eating disorders in the context of fitness and thinness, the potential genetic heritability, and developmentally specific age-of-onset shed some light on the aetiology of eating disorders. Research on various reactions of a brain neuropeptide called ⍺-melanocyte-stimulating-hormone (⍺-MSH), the gut microbiota and brain axis and, the monoamines- dopamine and serotonin aid in the understanding of the pathomechanisms behind eating disorders. This review aims to discuss the characteristics, risk factors, effects and the other features of anorexia nervosa and bulimia nervosa. It also elaborates on the pathophysiology of eating disorders
Big Data Analytics in Healthcare using Google Cloud
Authors: Jampala Teja Krishna
Published: July 2022

Abstract: The health care domain has undergone transformational change in the 21st century. The integration of new kinds of digital technologies has been acting as a catalyst. Big Data Analytics serves as a promising technology that has considerably changed how diverse functions are carried out in the health care discipline. It encompasses the integration as well as analysis of a humongous volume of data such as electronic health records, biomedical data and omics data [1]. The emphasis of the research is on Google Cloud and how it has been contributing to the health domain by evolving the health care paradigm and progressing research at scale and empowering diverse stakeholders to transform and innovate
Gut Microbiome and Health Assessment Due To Arsenic Toxicity: A Review
Authors: Abhishek jain  , Roshni jain  , Swati jain  , Subodh kumar jain  , Swati singh thakur
Published: July 2022

Arsenic is considered as a class 1 carcinogen and first among toxicants ranked by the Environmental Protection Agency. Arsenic toxicity includes  deleterious effect on  gut  microbiota, gastrointestinal  disorder, immunological  disturbances,  disrupting metabolism and compromising the host health. Over 103–104 microorganisms with possibly 500 to 1,000 different species inhabit within the gut with 150 times more genes than the human genome. They help to digest food and play an essential role in our well- being. Gut microbiota affects our whole metabolism as well as the immune system of the host. Arsenic induced toxicity is a major health  challenge  leading  to  many  neurological  and  immunological  problems  and  inhibits  the  growth  of  many  bacterial  species common in the gastrointestinal tract. The Gut microbiome carries multiple functions that are beneficial to the hosts. Arsenic exposure  will  be  a critical  concern  for  human  health.  Human  gut  microbiomes  may  be  biochemically  responsible  for  arsenic metabolism, change in  the arsenic compounds and several arsenical transformations that may lead to arsenic toxicity. Arsenic metabolism occurs in the liver by arsenic methyltransferase (AS3MT) which methylates it into the inorganic arsenic, and ultimately eliminated through  urine.  Recent  studies  showed  that  biotransformation of  gut  microbiome causes alteration  of  microbiome morphology and physiology that may alter the ArsBC gene activity due to arsenic toxicity. We aimed at summarising that arsenic induced perturbed gut microbiome communities that trigger systemic responses in diverse organs. Due to gut microbiota perturbation, changes in gut permeability and metabolism have been identified, and there is a shift in the population of gut bacterial species having arsenic resistant genes that result in disturbance of host metabolic homeostasis. Here we review known aspects of arsenic gut microbes' interaction, this will help to understand about arsenic toxicity with the gut microbiome and their deleterious effects.
The Combined Effectiveness of Piriformis Stretch and Muscle Activation Exercises in Patients with Sacroiliac Joint Pain.
Authors: Bhupendra Karki  , Abhijit Kalita  , Abhijit Dutta
Published: July 2022

Sacroiliac joint pain is one of the common misdiagnosed orthopedic causes of low back pain, which affects between 15 to 30 percent of individuals with mechanical low back pain below L5. The sacroiliac joint is found out to be a source of dysfunction and pain in 10% to 27% of suspected cases of patients with chronic low back pain. Clinicians use different electrotherapy modalities, biomechanical correction techniques, and exercises for addressing SI joint pain. Many studies have been undertaken to find out the efficacy of different treatment tools in combination or isolation. Likewise, there are studies done to understand the effect of piriformis stretch and muscles activation exercises on sacroiliac joint pain but, there exists very little evidence studying the combined effect of both the treatment tools. So our study aims to determine the combined effect of piriformis stretch and muscles activation exercises in patients with sacroiliac joint pain. About 30 subjects, both male and female with a primary diagnosis of sacroiliac joint pain by the physician were recruited into two groups. Group A having 15 patients received piriformis stretch and muscles activation exercises, and Group B having 15 patients received only muscles activation exercises.   All the subjects received therapy sessions thrice weekly for four weeks. Outcome measures used were the visual analog scale (VAS) and oswestry disability index(ODI). Pre- intervention assessment and post-intervention assessment was carried out for both groups and the received data was analyzed using paired and independent t-test. According to the results of the analysis, the average improvement of VAS for Group A and Group B were 2.33 and 3.53 respectively.  The paired  t-test  was 23.129  and 14.270,  which  is statistically  highly significant  (p-value  = 0.000).  The average  improvement  in oswestry disability index for group A and group B were 16.13 and 26.13 respectively using mean and standard deviation. The paired t-test was 11.014 and 6.934 respectively, which is statistically highly significant (p-value = 0.000).   There is a significant improvement in both Group A and Group B. However, Group A (piriformis stretch and muscle activation exercises) showed significant improvement in the treatment of sacroiliac joint pain. The results indicated that both Group A and Group B had significant improvement in the scores of VAS and ODI scores at the 4th week when compared  to baseline values, but when comparing the end results of group A and group B, it has been found out that group A intervention is more effective than Group B in treating patients with sacroiliac joint pain. From the data analysis reports, it can be concluded that when  these treatment  tools i.e piriformis  stretch  and muscles  activation  exercises  are  applied  in combination,  it gives  better  results  in the management of sacroiliac joint pain
A Comparative Study To Determine The Effects Of Maitland Mobilization Vs.Mulligan Mobilization With Movement (Mwm) With Retro-Walking In Osteoarthritis
Authors: Chadi Khriesakuonuo , Dutta Abhijit , Kalita Abhijit , Saikia Baruah Trishna
Published: July 2022

Osteoarthritis (OA) is a chronic progressive degenerative disorder of multifactorial etiology causing greater disability and clinical symptoms among adults. Physiotherapy is the mainstay of non-pharmacological treatment in osteoarthritis. It has shown that manual therapy combined with supervised exercise program is effective in reducing pain, disability, improving range of motion and strength in patients with knee osteoarthritis. Our aim is to determine the comparative effects of Maitland mobilization vs. Mulligan mobilization with movement (MWM) with retro-walking in osteoarthritis. This is a comparative study where 30 subjects, both Male and Female with a primary diagnosis of osteoarthritis knee by the physician was recruited into two groups or intervention sequence with 15 subjects in each group. Group-A received Maitland mobilization with retro-walking and Group-B received Mulligan mobilization with retro-walking. Home exercise program was incorporated for both groups. All subjects received intervention thrice weekly for 4 weeks. Outcome measures were Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) and 6 -minute walk test. Pre-Test and Post-Test was carried out for both groups and analyzed using paired and independent t tests in an SPSS software. It is concluded that both group-A (Maitland mobilization with retro-walking) and group-B (Mulligan mobilization with retro-walking) showed improvement post-treatment. However, the intervention given in group-B (Mulligan mobilization with retro-walking) showed significant improvement in VAS in terms of pain and WOMAC in terms of pain, stiffness and dysfunction compared to groupA (Maitland mobilization with retro-walking) whereas 6-minute walk test was found to be equally effective in both group-A and group-B. It is recommended for long term treatment and follow-up and retro-walking should be included in the rehabilitation of OA knee since the level of pain has been reduced.
Effect of Proprioceptive Neuromuscular Facilitation Technique versus Trunk Mobility Exercises On Improving Trunk Control In Hemiplegic Patients-A Comparative Study
Authors: Dihidar Niharika , S. Anita Devi  , Kalita Abhijit , Dutta Abhijit
Published: July 2022

The trunk control is a basic motor skill necessary to perform many functional tasks and is deficient in patients sufferingfrom cerebrovascular accident (CVA). Stroke or cerebrovascular accident (CVA) is an abrupt onset of a focal neurological deficitlasting more than 24 hours. The aim of the study is to evaluate the effectiveness of PNF technique over trunk mobility exercises forthe improvement of trunk control in hemiplegic patients. It is a comparative experimental study. This study includes (N=30) subjectswith hemiplegic patients within age group of 45-55 years. They were randomly assigned into 2 groups (Group A and B). Group Ahad 15 (N=15) subjects who are treated with Proprioceptive Neuromuscular Technique and Group B had 15 (N=15) who aretreated with Trunk Mobility Exercises. The subjects were given intervention of 4 days a week for 4 weeks. The outcome measuresused are Trunk Impairment Scales and Functional Independence Measure for trunk control and functional ability. This study was anexperimental study where pre-test and post-test design were used. Paired ‘t’ test and Independent ‘t’ test were done for statisticalanalysis. Statistically a highly significant difference is noticed between both the groups. The pre and post intervention mean of bothTIS score and FIM score was statistically significant (p=0.02) in both the groups. The results had shown that both groups notedsignificant difference. But when comparing between these two groups, there is statistical significance is noted. Therefore, on thebasis of the results, it can be concluded that, the present study provided more evidence to support the use of ProprioceptiveNeuromuscular Facilitation as compared to Trunk Mobility Exercises for improving trunk control in post stroke hemiplegic case.
Significance Of Interleukin-6 In Diabetes Mellitus And Its Complications
Authors: Chandrika A. Mary , Selvi Dr. V.S.Kalai
Published: July 2022

: Low grade inflammation is one of the causes in the pathogenesis of type 2 diabetes. Interleukin – 6 (IL-6) a proinflammatory cytokine is found to be increased in type 2 diabetic patients. This study was aimed to assess the role of Interleukin -6 in type 2 diabetes mellitus. This was a cross sectional study done among diabetics and non- diabetics. The total number of subjects involved in the study was 120 within the age group of 20-50 years attending the outpatient department and diabetic clinic of Sree Balaji Medical College and Hospital. The study group comprised of Group- I – 40, age and sex matched non diabetic subjects. Group- II – 40, type II diabetic patients with good control of blood glucose, Group III – 40, type II diabetic patients with poor glycemic control. Blood samples were taken after 8 hours of fasting period, centrifuged at 3000 rpm for 10 min and serum, plasma separated. Plasma glucose levels (FBG, PPBG) were estimated by GOD/POD method, IL- 6 levels were measured by ELISA method and HbA1c by immunoturbidimetric method. Data was statistically analyzed using the Statistical Package for the Social Sciences (SPSS) version 18. Results showed that the circulating Interleukin- 6 (IL-6) levels were found to be elevated in type 2 diabetics than non diabetic subjects (p < 0.0001). Raised level of Interleukin-6 was found in diabetics compared to non diabetics that showed the presence of inflammatory mechanisms in diabetes patients. Also uncontrolled diabetics have increased Interleukin-6 levels. In addition to periodic checking of HbA1c, it is paramount important to check the inflammatory status in high risk subjects for diabetes and also in diabetics to prevent diabetic complications.
Locomotor activity and spasticity level of the limb in female mice with a spinal cord injury model
Authors:   Bogomoletz Institute of Physiology, National Academy of Sciences, Kyiv, Ukraine, Nesterenko Yu. , Rybachuk O. ,   Bogomoletz Institute of Physiology, National Academy of Sciences, Kyiv, Ukraine; State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Published: July 2022

Spinal cord injuries (SCI) lead to large-scale physical, physiological, psychological and professional losses. Therefore, today, one of the urgent aims of neurophysiology is the study of the consequences of spinal cord injury. The most common type of SCI is a hemisection. For a comprehensive and detailed study of the functional post-traumatic recovery of the spinal cord, various hemisection options are developed. The aim of the study was to analyse the level of locomotor activity and changes in spasticity of the mice ipsilateral hindlimb (IH) after SCI. Materials and methods. The injury of the left-side spinal cord hemisection was modelled at the level of the lower thoracic segments (T10-T11) in female FVB mice. The locomotor activity and spasticity of the IH were determined every week using the Basso-Beattie-Bresnahan (ВВВ), the Basso (B) scales and the Ashworth scale during the first 1-12 weeks of the post-traumatic period. Results. At a later date (the 11th, 12th weeks) compared with the first weeks of the post-traumatic period, there was a marked recovery of the IH function: 4.39±0.61 points (out of 21 possible) on the BBB scale and 2.22±0.31 points (out of 9 possible) on the B scale. However, at all studied time interval after SCI, a consistently high level of hindlimb spasticity in experimental animals was noted, on the 12th week: 3.03±0.39 (out of 4 possible) on the Ashworth scale. Conclusions. After modelling spinal cord injury by hemisection, spontaneous post-traumatic recovery of locomotor activity was observed (since the 2nd week), which had scores corresponding to the early recovery phase. On the other hand, the levels of IH spasticity in mice were quite high throughout the entire study period, although already at the 2nd week there was a slight decrease in this parameter compared to the 1st week of the post-traumatic period.
Morphofunctional characteristics of adipose-derived multipotent mesenchymal stromal cells from CBA/Ca mice of different ages in cell culture in vitro
Authors:   State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ustymenko A. ,   D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Kyryk V. ,   State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Butenko G. ,   State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Published: July 2022

In modern regenerative medicine, the use of adipose-derived multipotent mesenchymal stromal cells (ADSCs) is an important strategy for the treatment of many diseases, including age-dependent ones. However, the question of a direct link between the aging of ADSCs and the aging of the body as a whole remains open. The purpose of the study was to determine the morphofunctional properties of multipotent mesenchymal stromal cells of adipose tissue in young and old mice when cultured in vitro. Materials and methods. Subcutaneous adipose tissue was isolated from young (2 months old) and old (14 months old) female CBA/Ca mice, fermented, and the stromal vascular fraction was obtained. ADSCs were isolated after cell culturing for 2nd passage. Cells were phenotyped by flow cytometry and morphological characteristics, proliferative potential, ability to directed multilinear differentiation in osteogenic, adipogenic directions were evaluated in vitro. Results. ADSCs obtained from old animals after the second passage showed a decrease in the proliferative, clonogenic potentials of ADSCs in vitro compared to the cells from young animals. In addition, the osteogenic potential of ADSCs in vitro decreased and the potential for adipogenic differentiation increased. Conclusions. The results of the study indicate an age-dependent effect on the functional activity of ADSCs, which is manifested by a disorder of their potential for proliferation, colony formation and directed differentiation.
Morphometric analysis of skin in ovariectomized mice of different ages
Authors:   D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ivanishchev V. ,   State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ustymenko A. ,   D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Butenko G. ,   D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Published: July 2022

It is known that a deficiency of estrogens of any origin (physiological menopause, surgical removal of the ovaries, etc.) accelerates the aging processes of both the body in general and the skin in particular in women. Studies of the morphometric properties of skin caused by estrogen-deficient states may help in the development of more effective regenerative medicine approaches aimed at treating and preventing age-related skin changes. The purpose of the study is to determine the morphological changes in the skin of young and old SBA/Сa mice with estrogen deficiency on the ovariectomy model. Materials and methods. Skin samples from young (4 months) and old (16 months) mice two months after ovariectomy were compared with age-matched sham-operated mice. The thickness of the epidermis and dermis, the number of hair follicles, and sebaceous glands were determined on histological samples of the skin. Results and discussion. It was shown that the thickness of the epidermis was significantly smaller both in the group of young and in the group of old ovariectomized mice compared to the thickness of the epidermis of the control group of animals of the corresponding age. A significant increase in the thickness of the dermis was found in the group of young ovariectomized mice in comparison with the thickness of the dermis in the young control group, however, in the group of old ovariectomized mice, the thickness of the dermis did not differ significantly compared to the age-matched control group. No significant differences were found in the number of sebaceous glands and hair follicles in the studied groups. Conclusions. Ovariectomy, as a model of artificial estrogen deficiency, is accompanied by significant changes in the epidermis in young and old animals and the dermis in young ovariectomized animals, without affecting the number of sebaceous glands and hair follicles.
Traversing boundaries inside the heart
Authors: Oliveira Ines , Cruz Isabel , Bragança Bruno , Lopes Rafaela , Azevedo João , Andrade Aurora
Published: July 2022

Paradoxical embolism is often a presumptive diagnosis as definitive
evidence of venous thrombi, arterial embolism and a clot traversing a
cardiac defect is extremely uncommon. We present a rare case report of a
patient diagnosed with paradoxical embolism, in whom a
thrombus-in-transit through a patent foramen ovale was identified.
Recovery from heat-induced infertility -- a study of reproductive tissue responses and fitness consequences in male Drosophila melanogaster
Authors: Canal Berta , Fricke Claudia
Published: July 2022

The predicted temperature increase caused by climate change is a threat
to biodiversity. Male reproduction is particularly sensitive to elevated
temperatures resulting in sterility. Here we investigate temperature
induced changes in reproductive tissues and the fertility reduction in
male Drosophila melanogaster. We challenged males during development and
either allowed them to recover or not in early adulthood, while
measuring several determinants of male reproductive success. We found
significant differences in recovery rate, organ sizes, sperm production
and other key reproductive traits among males from our different
temperature treatments. Spermatogenesis and hence sperm maturation was
impaired before reaching the upper thermal sterility threshold. While
some effects were reversible, this did not compensate the earlier damage
imposed. Surprisingly, developmental heat stress was damaging to
accessory gland growth and female post mating responses mediated by
seminal fluid proteins were impaired regardless of the possibility of
recovery. We suggest that sub-lethal thermal sterility and the
subsequent fertility reduction is caused by a combination of
malfunctioning reproductive traits: inefficient functionality of the
accessory gland and alteration of spermatogenesis.
Coronary artery bypass graft (CABG): A 13 year outcome in 65-year-old patient
Authors: Nadeem Abdullah
Published: July 2022

A 65-year-old patient with LAD ostial stenosis proved by coronary
angiography is presented. LAD ostial stenosis is an uncommon condition
whose etiology is unknown. The patient also had a CABG 13 years ago
after which complications occurred. The clinical and angiographic
profile of the patient are discussed here supported by literature.
Detailed in-situ leaf energy budget permits the assessment of leaf aerodynamic resistance as a key to enhance non-evaporative cooling under drought
Authors: Muller Jonathan , Rotenberg Eyal , Tatarinov Fedor , Oz Itay , Yakir Dan
Published: July 2022

The modulation of the leaf energy budget components to maintain optimal
leaf temperature are fundamental aspects of plant functioning and
survival. Better understanding these aspects becomes increasingly
important under a drying and warming climate when cooling through
evapotranspiration (ET) is suppressed. Combining novel measurements and
theoretical estimates, we obtained unusually comprehensive twig-scale
leaf energy budgets under extreme field conditions in droughted
(suppressed ET) and non-droughted (enhanced ET) plots of a semi-arid
pine forest. Under the same high mid-summer radiative load, leaf cooling
shifted from relying on nearly equal contributions of sensible (
H) and latent ( LE) energy fluxes in non-droughted trees
to relying almost exclusively on H in droughted ones, with no
change in leaf temperature. Relying on our detailed leaf energy budget,
we could demonstrate that this is due to a 2× reduction in leaf
aerodynamic resistance. This capability for LE-to-H shift in leaves of
mature Aleppo pine trees under droughted field conditions without
increasing leaf temperature is likely a critical factor in the
resilience and relatively high productivity of this important
Mediterranean tree species under drying conditions.
Complete Response to Intravesical Gemcitabine in Non-Muscle Invasive Bladder Cancer Patient after BCG Failure A Case Report and Literature Review
Authors: Nahhat Fouad , Doyya Modar , Ksiri Hazem
Published: July 2022

Bladder cancer treatment remains a challenge to every oncologist. We
report the case of a 57-year-old man with BCG-refractory bladder cancer,
who had a complete response to the intravesical Gemcitabine to shine the
light on the role of Gemcitabine as a bladder sparing treatment in
BCG-failure patients.
Civil Society Brief: Armenia
Authors:   Asian Development Bank, Qi Wen
Published: July 2022

Սույն ակնարկը քննարկում է Հայաստանում քաղաքացիական հասարակության զարգացումը, որը հիմնված է քաղաքացիների ճկունության և նվիրվածության վրա, և ամրապնդվում է քաղաքացիական հասարակության կազմակերպությունների՝ տնտեսական, ինստիտուցիոնալ և քաղաքական բարեփոխումներում ակտիվ ներգրավվածությամբ:
FUNGSI TRADISI LAGU NENGGO DI DUSUN TUNGKU, DESA GOLO, KECAMATAN CIBAL, MANGGARAI SEBAGAI MEDIA PENGENDALIAN SOSIAL DAN POTENSINYA SEBAGAI SUMBER BELAJAR SOSIOLOGI DI SMA
Authors: Agas Albertus , Pageh I Made , Yasa I Wayan Putra
Published: July 2022

Penelitian ini bertujuan untuk (1) Mengidentifiksi alasan penggunaan lagu Nenggo sebagai media pengendalian sosial di Dusun Tungku, Desa Golo, Kecamatan Cibal, Kabupaten Manggarai, Nusa Tenggara Timur. (2) Untuk mengetahui implementasian lagu Nenggo dalam upaya pengendalian sosial di Dusun Tungku. (3)  Untuk mengetahui aspek-aspek yang terdapat pada lagu Nenggo yang berpotensi sebagai sumber belajar sosiologi di SMA. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif. Objek dalam penelitian ini adalah masyarakat Dusun Tungku, Desa Golo, Kecamatan Cibal, Kabupaten Manggarai, Nusa Tenggara Timur dengan informan kunci sebagai kepala adat, Kepala Dusun, Dewan Stasi serta tokoh adat dan tokoh agama yang berasal dari Dusun Tungku. Hasil penelitian menunjukan bahwa: (1) Tradisi lagu Nenggo dapat dijadikan sebagai media pengendalian sosial di Dusun Tungku berdasarkan karakteristiknya, fungsinya, cara-cara dan sifat pengendalian sosial. (2) Implementasi tradisi lagu Nenggo secara preventif yaitu mendidik, mengajak, melarang dan mengingatkan dan secara represif yaitu penyebaran rasa malu dan takut, sebagai media keritik sosial dan sebagai penguatan kepercayaan rakyat (3) Fungsi lagu Nenggo sebagai media pengendalian sosial berpotensi sebagai sumber belajar sosiologi di SMA sesuai dengan kompetensi dasar (KD) dan kompetensi inti (KI). Fungsi tradisi lagu Nenggo sebagai media pengendalian sosial juga memenuhi kompetensi siswa yaitu kompetensi kognitif, afektif dan pesikomotorik.
REVOLUSI PANDEMI COVID-19
Authors: Rachman Adelia Hanny
Published: July 2022

Sejak masuknya SARS-CoV-2 di Indonesia pada awal tahun 2020 hingga November 2021, terdapat lebih dari 4 juta warga negara Indonesia terkonfirmasi positif Covid-19 dengan lebih dari 11 ribu kasus aktif (Satgas Penanganan Covid-19). Segala akibat pandemi Covid-19 yang dirasakan oleh hampir seluruh masyarakat dunia merupakan suatu cerminan deglobalisasi. Kondisi ini juga menjadi titik balik pengaturan ulang global dan juga dapat dipertimbangkan sebagai revolusi hening yang membawa perubahan mendasar dalam tatanan kehidupan manusia. Setidaknya pandemi mempertaruhkan dua unsur dasar penting yang menyangkut kelangsungan hidup manusia, yakni ekonomi dan kesehatan. Selama ini globalisasi menuntut dunia bergerak dinamis dan mengepakkan sayap kapitalisme, khususnya sejak abad ke-18 ketika teknologi informasi dan komunikasi berkembang pesat. Tragedi hari ini justru mendorong manusia melakukan perubahan secara signifikan dan fundamental guna memelihara kelangsungan hidup bersama. Artikel ini ditulis dengan perspektif makrososiologis untuk melihat akibat pandemi Covid-19 terhadap korelasi sosial dalam hal primer kehidupan masyarakat Indonesia.
SOLIDARITAS SOSIAL NELAYAN PADA MASA PACEKLIK DI DESA RANDU PUTIH, KABUPATEN PROBOLINGGO DAN POTENSINYA SEBAGAI SUMBER BELAJAR SOSIOLOGI DI SMA
Authors: Ardiyansah Ahmad , Margi I Ketut , Yasa I Wayan Putra
Published: July 2022

Penelitian ini bertujuan untuk mengetahui bentuk solidaritas sosial masyarakat nelayan di Desa Randu Putih Kecamatan Dringu, Kabupaten Probolinggo pada masa panceklik, Untuk mengetahui faktor penghambat dan pendukung solidaritas sosial masyarakat nelayan di Desa Randu Putih Kecamatan Dringu, Kabupaten Probolinggo pada masa paceklik, Untuk mengetahui solidaritas sosial masyarakat nelayan pada masa paceklik di Desa Randu Putih Kecamatan Dringu, Kabupaten Probolinggo pada masa paceklik yang dapat digunakan sebagai sumber belajar sosiologi di SMA. Pada penelitian ini peneliti  menggunakan pendekatan deskritif kualitatif dengan metode pengumpulan data berupa observasi, wawancara, dan studi dokumen/analisis content dan purposive sampling. Adapun jenis data yang digunakan terbagi menjadi dua yaitu data primier dan data sekunder. Berdasarkan penelitian yang telah dilaksanakan. (1) terdapat dua bentuk solidaritas sosial nelayan pada masa paceklik di Desa Randu Putih, Kabupaten Probolinggo yaitu kerjsama dan gotong royong. (2) adapun faktor penghambat solidaritas sosial pada masa paceklik Desa Randu Putih, Kabupaten Probolinggo yaitu dari faktor penghambat yaitu modernisasi, materialisme, faktor pendukung yaitu budaya, agama dan ikatan kelurga, (3)  memberikan  sumber  belajar di luar buku teks. Hal ini bertujuan untuk memberikan wawasan terkait realitas kehidupan manusia dalam kelompok sosial, tentu ini menjadi cara yang lebih efektif agar proses pembelajaran tidak berkesan membosankan.
ANALISIS MODEL PEMBELAJARAN PROJECT BASED LEARNING DALAM PERSPEKTIF SOSIOLOGI PENDIDIKAN
Authors: Sulistiana Patma , Setiawan Rizki
Published: July 2022

Tujuan penelitian ini adalah untuk menggambarkan analisis model pembelajaran project based learning dalam perspektif sosiologi pendidikan. Metode yang digunakan adalah deskriptif kualitatif, dengan teknik pengumpulan data observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan data reducation, data display, dan verification serta teknik keabsahan data dengan triangulasi sumber. Teknik pemilihan informan menggunakan purposive sampling, dengan informan dosen dan mahasiswa Pendidikan Sosiologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Sultan Ageng Tirtayasa yang melakukan model pembelajaran project based learning. Hasil penelitian menunjukan bahwa implementasi model pembelajaran project based learning terbagi menjadi 4 tahap, pertama yaitu perencanaan, yang dilakukan dengan pengelompokan mahasiswa dan penentuan permasalahan. Kedua yaitu perancangan, dengan menyusun timeline dan rancangan penelitian. Ketiga yaitu pelaksanaan, dengan melakukan penelitian dan evaluasi. Keempat yaitu pelaporan dengan melakukan presentasi hasil akhir. Model pembelajaran project based learning dalam perspektif sosiologi pendidikan memberikan pembelajaran yang mandiri, bermakna, dan mendalam bagi mahasiswa
ANALISIS PENGEMBANGAN ORGANISASI MELALUI PROSES DIAGNOSA DENGAN MODEL WEISBORD
Authors: Hardiyansyah H , Firmansyah Ade
Published: July 2022

Penelitian ini bertujuan untuk melakukan diagnosa dan pengembangan organisasi terhadap Kantor Pelayanan, Penyuluhan dan Konsultasi Perpajakan (KP2KP). Berdasarkan hasil diagnosa organisasi terhadap KP2KP Indralaya dengan menggunakan 6 variabel model Weisbord diperoleh nilai rata-rata untuk seluruh variabel sebesar 4,10, sehingga organisasi KP2KP Indralaya secara keseluruhan dapat dikatakan baik atau tidak bermasalah bahkan mendekati kondisi sangat baik. Untuk variabel tujuan, tata hubungan dan kepemimpinan, organisasi KP2KP Indralaya memperoleh klasifikasi sangat baik. Sedangkan untuk variabel struktur organisasi, penghargaan dan mekanisme tata kerja memperoleh klasifikasi baik atau tidak bermasalah. Dengan demikian, organisasi KP2KP Indralaya perlu melakukan restrukturisasi organisasi, penghargaan dan mekanisme tata kerja dengan mencari solusi atas semua kendala yang menghambat kinerja organisasi KP2KP Indralaya dan tetap mempertahankan kinerja untuk variabel tujuan, tata hubungan dan kepemimpinan sehingga secara keseluruhan organisasi KP2KP Indralaya akan memperoleh klasifikasi sangat baik
FUNGSI FOLAYA PADA ACARA FOKO’O SIMATE DALAM UPACARA KEMATIAN MASYARAKAT NIAS
Authors: Zebua Ayu Marnila , Rahayu Tuti
Published: July 2022

Abstract - This study aims to describe the function of Folaya at the Foko'o Simate event in the traditional ceremony of the death of the Nias community, especially in Hiliweto village, Gido District, Nias Regency. The theory used in this study is the theory of M. Jazuli about the function of dance as a means of traditional ceremonies related to events in human life in the form of death. The population in this study is the Nias community in Hiliweto Village, Gido District, Nias Regency, such as traditional leaders, community leaders, artists and cultural experts. The sample refers to 6 people, namely 2 artists, 2 cultural observers, 1 traditional leader and 1 community leader who clearly know about Folaya at the Nias community death ceremony. The research method used in this research is descriptive qualitative method with data collection techniques in the form of observation, interviews and documentation in the field. In qualitative research methods, research results are described and described in accordance with the facts on the ground. The results of the study indicate that Folaya functions as a means of traditional ceremonies in the Nias community's death ceremony which is a medium for conveying respect to someone who has died. Keywords: Folaya, Function, Death Ceremony       Abstrak – Penelitian ini bertujuan untuk mendeskripsikan fungsi Folaya pada acara Foko’o Simate dalam upacara adat kematian masyarakat Nias khususnya di desa Hiliweto, Kecamatan Gido, Kabuparen Nias. Teori yang digunakan dalam penelitian ini adalah teori dari M. Jazuli tentang fungsi tari sebagai sarana upacara adat yang berkaitan dengan peristiwa kehidupan manusia berupa kematian. Populasi dalam penelitian ini yaitu masyarakat Nias yang ada di Desa Hiliweto, Kecamatan Gido, Kabupaten Nias seperti tokoh adat, tokoh masyarakat, seniman dan budayawan. Sampel merujuk pada 6 orang yaitu 2 seniman, 2 budayawan, 1 tokoh adat dan 1 tokoh masyarakat yang mengetahui secara jelas tentang Folaya pada upacara kematian masyarakat Nias. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi di lapangan. Dalam metode penelitian kualitatif, hasil penelitian digambarkan dan diuraikan sesuai dengan fakta yang ada di lapangan. Hasil penelitian mengatakan bahwa Folaya  berfungsi sebagai sarana upacara adat dalam upacara kematian masyarakat Nias yang menjadi media penyampaian rasa hormat kepada seseorang yang sudah meninggal. Kata Kunci: Folaya, Fungsi, Upacara Kematian.