bluuebunny/crossref_metadata_2025 huggingface dataset:
The Braconid Syntretomorpha szaboi Papp Is Posing a Great Threat to the Eastern Honeybee, Apis cerana
Authors: Xie Yanling , Su Xiaoling , Wei Ruike , Cao Lianfei , Zheng Huoqing
Published: May 2024

The expansion of pathogen distribution may result in a new threat to the host. The braconid Syntretomorpha szaboi Papp is an obligate parasite that targets Apis cerana, the Eastern honeybee, engaging in endoparasitism by ovipositing eggs inside the host bee. Although S. szaboi has been documented in India and in various regions across China, its epidemiological data are notably lacking. In this study, we summarized the distribution of S. szaboi based on the available literature and described the symptoms of infested honeybee workers. We also investigated the infestation rate in 36 apiaries in Zhejiang Province, China, after a new occurrence of the parasite was reported in these regions in 2020. A rapid increase in infestation rate was found from the year 2021 to 2022, reaching 53.88% at the colony level of the sampled colonies in the Jinhua and Wenzhou apiaries. The infestation rate at an individual level in positive colonies reached an average of 26%. A monthly survey showed high seasonal variation in S. szaboi infestation, with the peak occurring from May to August. These results suggest that S. szaboi poses a great threat to A. cerana. Further research is needed to elucidate its epidemiology and pathology and to develop disease prevention and control strategies.
Phage Therapy for Cardiac Implantable Electronic Devices and Vascular Grafts: A Targeted Literature Review
Authors: Passerini Matteo , Petri Francesco , Suh Gina A.
Published: May 2024

Infections of cardiac implantable electronic devices (CIEDs) and vascular grafts are some of the most dreaded complications of these otherwise life-saving devices. Many of these infections are not responsive to conventional treatment, such as systemic antibiotics and surgical irrigation and debridement. Therefore, innovative strategies to prevent and manage these conditions are warranted. Among these, there is an increasing interest in phages as a therapeutical option. In this review, we aim to collect the available evidence for the clinical application of phage therapy for CIED and vascular graft infections through literature research. We found 17 studies for a total of 34 patients. Most of the indications were left ventricular assist device (LVAD) (n = 20) and vascular graft infections (n = 7). The bacteria most often encountered were Staphylococcus aureus (n = 18) and Pseudomonas aeruginosa (n = 16). Clinical improvements were observed in 21/34 (61.8%) patients, with microbiological eradication in 18/21 (85.7%) of them. In eight cases, an adverse event related to phage therapy was reported. Phage therapy is a promising option for difficult-to-treat CIED and vascular graft infections by means of an individualized approach. Clinical trials and expanded access programs for compassionate use are needed to further unveil the role of phage therapy in clinical application.
Neuromodulation and the Gut–Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders
Authors: Aljeradat Baha’ , Kumar Danisha , Abdulmuizz Sulaiman , Kundu Mrinmoy , Almealawy Yasser F. , Batarseh Dima Ratib , Atallah Oday , Ennabe Michelle , Alsarafandi Muath , Alan Albert , Weinand Martin
Published: May 2024

The gut–brain axis (GBA) represents a complex, bidirectional communication network that intricately connects the gastrointestinal tract with the central nervous system (CNS). Understanding and intervening in this axis opens a pathway for therapeutic advancements for neurological and gastrointestinal diseases where the GBA has been proposed to play a role in the pathophysiology. In light of this, the current review assesses the effectiveness of neuromodulation techniques in treating neurological and gastrointestinal disorders by modulating the GBA, involving key elements such as gut microbiota, neurotrophic factors, and proinflammatory cytokines. Through a comprehensive literature review encompassing PubMed, Google Scholar, Web of Science, and the Cochrane Library, this research highlights the role played by the GBA in neurological and gastrointestinal diseases, in addition to the impact of neuromodulation on the management of these conditions which include both gastrointestinal (irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gastroesophageal reflux disease (GERD)) and neurological disorders (Parkinson’s disease (PD), Alzheimer’s disease (AD), autism spectrum disorder (ASD), and neuropsychiatric disorders). Despite existing challenges, the ability of neuromodulation to adjust disrupted neural pathways, alleviate pain, and mitigate inflammation is significant in improving the quality of life for patients, thereby offering exciting prospects for future advancements in patient care.
Progress and Innovative Combination Therapies in Trop-2-Targeted ADCs
Authors: Jiang Yizhi , Zhou Haiting , Liu Junxia , Ha Wentao , Xia Xiaohui , Li Jiahao , Chao Tengfei , Xiong Huihua
Published: May 2024

Precise targeting has become the main direction of anti-cancer drug development. Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely in normal tissues, rendering it an attractive target. Trop-2-targeted antibody-drug conjugates (ADCs) have displayed promising efficacy in treating diverse solid tumors, especially breast cancer and urothelial carcinoma. However, their clinical application is still limited by insufficient efficacy, excessive toxicity, and the lack of biological markers related to effectiveness. This review summarizes the clinical trials and combination therapy strategies for Trop-2-targeted ADCs, discusses the current challenges, and provides new insights for future advancements.
Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2′,4′-Dimethoxychalcone
Authors: Zhao Peiling , Xu Mengzhen , Gong Kai , Lu Kaihui , Ruan Chen , Yu Xin , Zhu Jiang , Guan Haixing , Zhu Qingjun
Published: May 2024

Chalcone (1,3-diaryl-2-propen-1-one) is an α, β-unsaturated ketone that serves as an active constituent or precursor of numerous natural substances, exhibiting a broad spectrum of pharmacological effects. In this study, the classical Claisen–Schmidt condensation method was used to synthesize the chalcone derivative 2′,4′-dimethoxychalcone (DTC) and evaluate its pharmacological activity. By upregulating the expression of the epithelial cell marker E-cadherin and downregulating the expression of the mesenchymal cell marker vimentin, DTC was found to inhibit transforming growth factor-β1 (TGF-β1)-induced epithelial–mesenchymal transition (EMT) process in A549 cells, maintaining the cells’ epithelial-like morphology and reducing the ability of the cells to migrate. Additionally, DTC demonstrated the ability to decrease the expression levels of nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in RAW264.7 cells, suggesting a possible anti-inflammatory effect. Furthermore, DTC was found to exhibit bacteriostatic activity against Staphylococcus aureus (S. aureus), Proteus vulgaris (P. vulgaris), methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans (C. albicans), indicating that this chemical may possess broad-spectrum antibacterial activity.
Exploring the Potential Biological Activities of Pyrazole-Based Schiff Bases as Anti-Diabetic, Anti-Alzheimer’s, Anti-Inflammatory, and Cytotoxic Agents: In Vitro Studies with Computational Predictions
Authors: Naglah Ahmed M. , Almehizia Abdulrahman A. , Al-Wasidi Asma S. , Alharbi Amirah Senaitan , Alqarni Mohammed H. , Hassan Ashraf S. , Aboulthana Wael M.
Published: May 2024

In this innovative research, we aim to reveal pyrazole-based Schiff bases as new multi-target agents. In this context, we re-synthesized three sets of pyrazole-based Schiff bases, 5a–f, 6a–f, and 7a–f, to evaluate their biological applications. The data from in vitro biological assays (including antioxidant and scavenging activities, anti-diabetes, anti-Alzheimer’s, and anti-inflammatory properties) of the pyrazole-based Schiff bases 5a–f, 6a–f, and 7a–f showed that the six pyrazole-based Schiff bases 5a, 5d, 5e, 5f, 7a, and 7f possess the highest biological properties among the compounds evaluated. The cytotoxicity against lung (A549) and colon (Caco-2) human cancer types, as well as normal lung (WI-38) cell lines, was evaluated. The data from the cytotoxicity investigation demonstrated that the three Schiff bases 5d, 5e, and 7a are active against lung (A549) cells, while the two Schiff bases 5e and 7a exhibited the highest cytotoxicity towards colon (Caco-2) cells. Additionally, the enzymatic activities against caspase-3 and Bcl-2 of the six pyrazole-based Schiff bases 5a, 5d, 5e, 5f, 7a, and 7f were evaluated. Furthermore, we assessed the in silico absorption, distribution, metabolism, and toxicity (ADMT) properties of the more potent pyrazole-based Schiff bases. After modifying the structures of the six pyrazole-based Schiff bases, we plan to further extend the studies in the future.
Spray-Dried Nanolipid Powders for Pulmonary Drug Delivery: A Comprehensive Mini Review
Authors: Abu Elella Mahmoud H. , Al Khatib Arwa Omar , Al-Obaidi Hisham
Published: May 2024

Lung diseases have received great attention in the past years because they contribute approximately one-third of the total global mortality. Pulmonary drug delivery is regarded as one of the most appealing routes to treat lung diseases. It addresses numerous drawbacks linked to traditional dosage forms. It presents notable features, such as, for example, a non-invasive route, localized lung drug delivery, low enzymatic activity, low drug degradation, higher patient compliance, and avoiding first-pass metabolism. Therefore, the pulmonary route is commonly explored for delivering drugs both locally and systemically. Inhalable nanocarrier powders, especially, lipid nanoparticle formulations, including solid-lipid and nanostructured-lipid nanocarriers, are attracting considerable interest in addressing respiratory diseases thanks to their significant advantages, including deep lung deposition, biocompatibility, biodegradability, mucoadhesion, and controlled drug released. Spray drying is a scalable, fast, and commercially viable technique to produce nanolipid powders. This review highlights the ideal criteria for inhalable spray-dried SLN and NLC powders for the pulmonary administration route. Additionally, the most promising inhalation devices, known as dry powder inhalers (DPIs) for the pulmonary delivery of nanolipid powder-based medications, and pulmonary applications of SLN and NLC powders for treating chronic lung conditions, are considered.
A Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for Measuring Fosfomycin Concentrations in Human Prostatic Tissue
Authors: Conti Matteo , Giorgi Beatrice , Barone Rossella , Gatti Milo , Cojutti Pier Giorgio , Pea Federico
Published: May 2024

The aim of this study was to develop and validate a fast and sensitive bioanalytical method for the accurate quantification of fosfomycin concentrations in human prostatic tissue. The sample preparation method only required milligrams of tissue sample. Each sample was mixed with two times its weight of water and homogenized. A methanol solution that was three times the volume of the internal standard (fosfomycin-13C3) was added, followed by vortex mixing and centrifugation. After its extraction from the homogenized prostatic tissue, fosfomycin was quantified by means of a liquid chromatography–tandem mass spectrometry (LC-MS/MS) triple quadrupole system operating in negative electrospray ionization and multiple reaction monitoring detection mode. The analytical procedure was successfully validated in terms of specificity, sensitivity, linearity, precision, accuracy, matrix effect, extraction recovery, limit of quantification, and stability, according to EMA guidelines. The validation results, relative to three QC levels, were 9.9% for both the within-day and inter-day accuracy (BIAS%); 9.8% for within-day precision; and 9.9 for between-day precision. A marked matrix effect was observed in the measurements but was corrected by normalization with the internal standard. The average total recovery was high (approximatively 97% at the three control levels). The dynamic range of the method was 0.1–20 μg/g (R2 of 0.999). Negligible carry-over was observed after the injection of highly concentrated samples. F in the sample homogenate extracts was stable at 10 °C and 4 °C for at least 24 h. In the tissue sample freeze–thaw experiments, a significant decrease in F concentrations was observed after only two cycles from −80 °C to room temperature. The novel method was successfully applied to measure fosfomycin in prostatic tissue samples collected from 105 patients undergoing prostatectomy.
Management of Secondary Metabolite Synthesis and Biomass in Basil (Ocimum basilicum L.) Microgreens Using Different Continuous-Spectrum LED Lights
Authors: Fayezizadeh Mohammad Reza , Ansari Naser Alemzadeh , Sourestani Mohammad Mahmoodi , Fujita Masayuki , Hasanuzzaman Mirza
Published: May 2024

Different LED light spectra (LS) are absorbed by different plant photoreceptors and can control biomass and plant secondary metabolite synthesis. In this study, the effects of continuous-spectrum LED lights (red, blue, white, red + blue, and 12 h blue + 12 h red) on the production value, antioxidant compounds, and biomass of basil (Ocimum basilicum L.) microgreens (Red Rubin, Violeto, and Kapoor cultivars and the Ablagh genotype) were investigated. The results showed significant effects of LS on cultivar (Cv) and the interaction of LS and Cv on the studied traits. The highest quantitys of chlorophyll a, total chlorophyll, and nitrate were obtained in Violeto under blue lighting. Red lighting enhanced starch synthesis in Red Rubin and flavonoids in the Violeto Cv. The highest biomass (4.54 kg m−2) was observed in the Ablagh genotype and the highest carbohydrate synthesis in Violeto Cv in the red + blue treatment. The highest anthocyanin content (26.33 mg 100 g−1 FW) was observed for Red Rubin Cv under 12 h blue + 12 h red light. The greatest antioxidant capacity (83.57% inhibition), the highest levels of phenolic compounds (2027.25 mg GA 100 g−1 FW), vitamin C (405.76 mg 100 g−1 FW), proline, antioxidant potential composite index (APCI), and the greatest production values were obtained for the Ablagh genotype under blue lighting. Taken together, the experiment findings indicate that growing the Ablagh genotype under continuous blue lighting can increase the antioxidant capacity, phenolic compounds, and vitamin C and that this LED light spectrum can be used as a practical method to produce basil microgreens with high nutritional health value.
Comprehensive Evaluation and Selection of 192 Maize Accessions from Different Sources
Authors: Hu Mengting , Tian Huijuan , Yang Kaizhi , Ding Shuqi , Hao Ying , Xu Ruohang , Zhang Fulai , Liu Hong , Zhang Dan
Published: May 2024

In the period 2022–2023, an analysis of fourteen phenotypic traits was conducted across 192 maize accessions in the Aral region of Xinjiang. The Shannon–Wiener diversity index was employed to quantify the phenotypic diversity among the accessions. Subsequently, a comprehensive evaluation of the index was performed utilizing correlation analysis, principal component analysis (PCA) and cluster analysis. The results highlighted significant findings: (1) A pronounced diversity was evident across the 192 maize accessions, accompanied by complex interrelationships among the traits. (2) The 14 phenotypic traits were transformed into 3 independent indicators through principal component analysis: spike factor, leaf width factor, and number of spikes per plant. (3) The 192 materials were divided into three groups using cluster analysis. The phenotypes in Group III exhibited the best performance, followed by those in Group I, and finally Group II. The selection of the three groups can vary depending on the breeding objectives. This study analysed the diversity of phenotypic traits in maize germplasm resources. Maize germplasm was categorised based on similar phenotypes. These findings provide theoretical insights for the study of maize accessions under analogous climatic conditions in Alar City, which lay the groundwork for the efficient utilization of existing germplasm as well as the development and selection of new varieties.
First Evidence of Thalassochory in the Ficus Genus: Seed Dispersal Using the Kuroshio Oceanic Current
Authors: Pan Shin-Hung , Sun Ying-Hsuan , Tzeng Hsy-Yu , Rodriguez Lillian Jennifer , Bain Anthony
Published: May 2024

Aim: Plants distributed between southern Taiwan and the north of the Philippines are spread among numerous small islands in an area crossed by the powerful Kuroshio current. Oceanic currents can be effective seed-dispersal agents for coastal plant species. Moreover, the Luzon Strait is an area prone to tropical cyclones. The aim of this study is to look at the dispersal capability of an endangered coastal plant species, the Mearns fig (Ficus pedunculosa var. mearnsii), using both experimental and population genetics methods. Location: Southern Taiwan, the Philippines, and the islands between Luzon and Taiwan Island. Methods: This study combined two types of analysis, i.e., buoyancy experiments on syconia and double digest restriction-associated DNA sequencing (ddRAD), to analyze the population genetics of the Mearns fig. Results: We first discovered that mature Mearns fig syconia could float in seawater. They have a mean float duration of 10 days to a maximum of 21 days. Germination rates varied significantly between Mearns fig seeds that had undergone different durations of flotation treatment. Population genetic analysis shows a high degree of inbreeding among various Mearns fig populations. Moreover, no isolation by distance was found between the populations and individuals. Main conclusions: From our analysis of the genetic structure of the Mearns fig populations, we can clearly highlight the effect of the Kuroshio oceanic current on the seed dispersal of this fig tree. Comprehensive analysis has shown that Mearns fig seeds are still viable before the mature syconium sinks into the seawater, and so they could use the Kuroshio Current to float to the current population locations in Taiwan.
Canopy Architectural Characteristics of Ten New Olive (Olea europaea L.) Genotypes and Their Potential for Cultivation in Super-High-Density Orchards
Authors: Bufacchi Marina , Famiani Franco , Passeri Valentina , Domesi Andrea , Rosati Adolfo , Paoletti Andrea
Published: May 2024

In recent years, there has been growing interest in olive genotypes (Olea europaea L.) suitable for super-high-density (SHD > 1200 trees/hectare) orchards. To date, only a few cultivars are considered fitting for such cultivation system. In this study, the first results on the architectural characteristics of the canopy of ten new olive genotypes are presented. Their suitability for SHD orchards was evaluated and compared with the cultivar ‘Arbequina’, which is considered suitable for SHD olive orchards and, for this reason, was used as the control. Several canopy measurements were taken, and some architectural parameters, such as branching frequency, branching density, and branch diameter/stem diameter ratio were calculated. The branching frequency value was greater than 0.20 in ‘Arbequina’ and in only four of the genotypes. The branching density in five genotypes was similar to ‘Arbequina’. ‘Arbequina’ had the lowest value for the branch diameter/stem diameter ratio, and only three genotypes had similar values. These initial results showed that only one genotype has all canopy architectural characteristics comparable to those of the cv. ‘Arbequina’. Further studies are needed to evaluate the production traits of these new genotypes and complete their characterization.
Exogenous Cytokinin 4PU-30 Modulates the Response of Wheat and Einkorn Seedlings to Ultraviolet B Radiation
Authors: Kirova Elisaveta , Moskova Irina , Manova Vasilissa , Koycheva Yana , Tsekova Zoia , Borisova Denitsa , Nikolov Hristo , Dimitrov Ventzeslav , Sergiev Iskren , Kocheva Konstantina
Published: May 2024

Abiotic stress is responsible for a significant reduction in crop plant productivity worldwide. Ultraviolet (UV) radiation is a natural component of sunlight and a permanent environmental stimulus. This study investigated the distinct responses of young wheat and einkorn plants to excessive UV-B radiation (180 min at λmax 312 nm) following foliar pretreatment with 1 µM synthetic cytokinin 4PU-30. Results demonstrated that UV radiation significantly amplified hydrogen peroxide levels in both wheat and einkorn, with einkorn exhibiting a more pronounced increase compared to wheat. This elevation indicated the induction of oxidative stress by UV radiation in the two genotypes. Intensified antioxidant enzyme activities and the increased accumulation of typical stress markers and non-enzyme protectants were evidenced. Transcriptional activity of genes encoding the key antioxidant enzymes POX, GST, CAT, and SOD was also investigated to shed some light on their genetic regulation in both wheat and einkorn seedlings. Our results suggested a role for POX1 and POX7 genes in the UV-B tolerance of the two wheat species as well as a cytokinin-stimulated UV-B stress response in einkorn involving the upregulation of the tau subfamily gene GSTU6. Based on all our findings, it could be concluded that 4PU-30 had the potential of alleviating oxidative stress by attenuating the symptoms of superfluous UV-B illumination in the two examined plant species.
The Impacts of Planting Patterns Combined with Irrigation Management Practices on Watermelon Growth, Photosynthesis, and Yield
Authors: Qiang Xiaolin , Sun Zhaojun , Li Xingqiang , Li Siqi , Yu Zhao , He Jun , Li Qian , Han Lei , He Ling
Published: May 2024

(1) Background: Crop yields in China’s arid and semi-arid regions are limited by water shortages. Exploring the interactions and resource utilization among agroforestry species is key to maintaining diversified agricultural production. (2) Objective: An apple–watermelon agroforestry system and watermelon sole-cropping system were compared to quantify how resource availability (light, water) and watermelon performance (leaf photosynthetic rate, growth, and yield) change with irrigation strategies. (3) Methods: A three-year apple and watermelon field experiment was conducted in a young apple orchard in the arid area of central Ningxia to test the effect of light competition and irrigation systems on light environment, leaf photosynthetic rate, plant growth, and yield in watermelon. The experiment encompassed two planting patterns: (i) apple–watermelon agroforestry (AF) and watermelon sole-cropping (SC) and (ii) three irrigation quotas (W1: 105 mm, W2: 210 mm, and W3: 315 mm). (4) Results: The results show that the agroforestry planting pattern extended the growth period of watermelon and increased the leaf area index. Mean daily shade intensity increased by 16.02% from 2020 to 2022. The land equivalent ratio (LER) was >1 in 2021 and 2022. The SWC, leaf photosynthetic rate, LAI, and yield of watermelon in an agroforestry planting pattern were lower than when in a sole-cropping planting pattern. However, under the W1 irrigation strategy, the total soluble solids of the agroforestry planting pattern were 2.27% higher than those of the sole-cropping pattern, and the yield of the agroforestry planting pattern was 2.59% higher than that of the sole-cropping pattern. Under the W3 irrigation strategy, the average watermelon weight in the agroforestry planting pattern was 2.85% higher than that of the sole-cropping pattern. A path analysis showed that the agroforestry planting pattern can increase the yield by increasing soil water content, which is different from the sole-cropping pattern. (5) Conclusions: The results confirm that the apple–watermelon agroforestry planting pattern reduced watermelon yields. However, the LER of the agroforestry system was greater than 1.0. It is reasonable to plant watermelons in young apple forests.
Lyophilized Emulsions of Thymol and Eugenol Essential Oils Encapsulated in Cellulose
Authors: Shlosman Koranit , Rein Dmitry M. , Shemesh Rotem , Cohen Yachin
Published: May 2024

Efforts to tap into the broad antimicrobial, insecticidal, and antioxidant activities of essential oils (EOs) are limited due to their strong odor and susceptibility to light and oxidation. Encapsulation of EOs and subsequent drying overcome these limitations and extend their applications. This study characterized freeze-dried (lyophilized) emulsions of eugenol (EU) and thymol (TY) EOs, encapsulated by chemically unmodified cellulose, a sustainable and low-cost resource. High-resolution scanning electron microscopy showed successful lyophilization. While the observed “flake-like” structure of the powders differed significantly from that of the emulsified microcapsules, useful properties were retained. Fourier transform infrared spectroscopy confirmed the presence of EOs in their corresponding powders and thermo-gravimetric analysis demonstrated high encapsulation efficiency (87–88%), improved thermal stability and resistance to evaporation, and slow EO release rates in comparison to their free forms. The lightweight and low-cost cellulose encapsulation, together with the results showing retained properties of the dried powder, enable the use of EOs in applications requiring high temperatures, such as EO incorporation into polymer films, that can be used to protect agricultural crops from microbial infections.
Rapid Waste Motor Oil Conversion into Diesel-Range Hydrocarbons Using Hydrochar as Catalyst: Kinetic Study and Product Characterization
Authors: Murillo Herman A. , Juiña Evelyn , Vizuete Karla , Debut Alexis , Echeverría Daniel , Taco-Vasquez Sebastian , Ponce Sebastian
Published: May 2024

Herein, raw and alkali-treated hydrochars from biomass waste are prepared as a highly active catalyst for the conversion of waste motor oil into diesel-like fuels. Among all materials, hydrochar obtained at 250 °C and subsequent alkali activation with KOH showed a 600% improvement of the kinetic constant from 0.0088 to 0.0614 m−1. Conversion values at the same conditions were also improved from 66 to 80% regarding thermal and catalytic cracking, respectively. Moreover, the activation energy was also reduced from 293 to 246 kJ mol−1 for thermal and catalytic cracking, respectively. After characterization, the enhanced catalytic activity was correlated to an increased surface area and functionalization due to the alkali activation. Finally, the liquid product characterization demonstrated that catalytic cracking is more effective than thermal cracking for producing hydrocarbons in the diesel range. In particular, hydrochar-based catalysts are suggested to promote the formation of specific hydrocarbons so that the carbon distribution can be tailored by modifying the hydrothermal treatment temperature.
Faith, Knowledge, and the Ausgang of Classical German Philosophy: Jacobi, Hegel, Feuerbach
Authors: Gooch Todd
Published: May 2024

This article revisits Feuerbach’s “break with speculation” in the early 1840s in light of issues raised by the original Pantheism Controversy, initiated in 1785 by the publication of Friedrich Heinrich Jacobi’s Letters on the Doctrine of Spinoza. The article first describes the concerns underlying Jacobi’s repudiation of Spinozism, and rationalism more generally, in favor of a personalistic theism that disclaims the possibility of philosophical knowledge of God. It goes on to reconstruct Hegel’s alternative to Jacobi’s famous salto mortale before considering how Feuerbach’s critique of Hegel’s philosophy of religion, as well as the personalism of the so-called Positive Philosophy (inspired by the late Schelling), was influenced by both Spinoza and Jacobi in ways that have not yet received sufficient attention.
Belief in Religion or Participation in Insurance? The Impact of Religious Beliefs on the Decision to Participate in Social Health Insurance in China
Authors: Chai Mengran , Wu Lin
Published: May 2024

Investigating the factors that influence individual decisions to participate in social health insurance is an essential component of constructing a multi-tiered, comprehensive social health insurance system, and religious beliefs may constitute an important potential factor. Utilising data from the China General Social Survey (CGSS), this study has developed a comprehensive explanatory framework encompassing both macro- and micro-level analyses to ascertain the impact of religious beliefs on individual decisions to participate in social health insurance through quantitative methods. The findings indicate that religious beliefs significantly diminish the likelihood of individuals participating in social health insurance, and the influence varies among different types of religions; endogeneity and robustness tests offer robust support for these conclusions. With respect to heterogeneity, the influence of religious beliefs on the decision to participate in social health insurance exhibits differentiation across dimensions such as educational attainment, social trust levels, income levels, and self-rated health statuses. Furthermore, the social interaction effect and the employment opportunity effect are identified as potential mechanisms driving this influence.
Multi-Task Visual Perception for Object Detection and Semantic Segmentation in Intelligent Driving
Authors: Zhan Jiao , Liu Jingnan , Wu Yejun , Guo Chi
Published: May 2024

With the rapid development of intelligent driving vehicles, multi-task visual perception based on deep learning emerges as a key technological pathway toward safe vehicle navigation in real traffic scenarios. However, due to the high-precision and high-efficiency requirements of intelligent driving vehicles in practical driving environments, multi-task visual perception remains a challenging task. Existing methods typically adopt effective multi-task learning networks to concurrently handle multiple tasks. Despite the fact that they obtain remarkable achievements, better performance can be achieved through tackling existing problems like underutilized high-resolution features and underexploited non-local contextual dependencies. In this work, we propose YOLOPv3, an efficient anchor-based multi-task visual perception network capable of handling traffic object detection, drivable area segmentation, and lane detection simultaneously. Compared to prior works, we make essential improvements. On the one hand, we propose architecture enhancements that can utilize multi-scale high-resolution features and non-local contextual dependencies for improving network performance. On the other hand, we propose optimization improvements aiming at enhancing network training, enabling our YOLOPv3 to achieve optimal performance via straightforward end-to-end training. The experimental results on the BDD100K dataset demonstrate that YOLOPv3 sets a new state of the art (SOTA): 96.9% recall and 84.3% mAP50 in traffic object detection, 93.2% mIoU in drivable area segmentation, and 88.3% accuracy and 28.0% IoU in lane detection. In addition, YOLOPv3 maintains competitive inference speed against the lightweight YOLOP. Thus, YOLOPv3 stands as a robust solution for handling multi-task visual perception problems. The code and trained models have been released on GitHub.
Spatial Resolution as a Factor for Efficient UAV-Based Weed Mapping—A Soybean Field Case Study
Authors: Ubben Niklas , Pukrop Maren , Jarmer Thomas
Published: May 2024

The influence of spatial resolution on classification accuracy strongly depends on the research object. With regard to unmanned aerial vehicle (UAV)-based weed mapping, contradictory results on the influence of spatial resolution have been attained so far. Thus, this study evaluates the effect of spatial resolution on the classification accuracy of weeds in a soybean field located in Belm, Lower Saxony, Germany. RGB imagery of four spatial resolutions (0.27, 0.55, 1.10, and 2.19 cm ground sampling distance) corresponding to flight altitudes of 10, 20, 40, and 80 m were assessed. Multinomial logistic regression was used to classify the study area, using both pixel- and object-based approaches. Additionally, the flight and processing times were monitored. For the purpose of an accuracy assessment, the producer’s, user’s, and overall accuracies as well as the F1 scores were computed and analyzed for statistical significance. Furthermore, McNemar’s test was conducted to ascertain whether statistically significant differences existed between the classifications. A linear relationship between resolution and accuracy was found, with a diminishing accuracy as the resolution decreased. Pixel-based classification outperformed object-based classification across all the resolutions examined, with statistical significance (p < 0.05) for 10 and 20 m. The overall accuracies of the pixel-based approach ranged from 80 to 93 percent, while the accuracies of the object-based approach ranged from 75 to 87 percent. The most substantial drops in the weed-detection accuracy with regard to altitude occurred between 20 and 40 m for the pixel-based approach and between 10 and 20 m for the object-based approach. While the decline in accuracy was roughly linear as the flight altitude increased, the decrease in the total time required was exponential, providing guidance for the planning of future UAV-based weed-mapping missions.
Improved Wetland Mapping of a Highly Fragmented Agricultural Landscape Using Land Surface Phenological Features
Authors: Wen Li , Mason Tanya , Powell Megan , Ling Joanne , Ryan Shawn , Bernich Adam , Gufu Guyo
Published: May 2024

Wetlands are integral components of agricultural landscapes, providing a wide range of ecological, economic, and social benefits essential for sustainable development and rural livelihoods. Globally, they are vulnerable ecological assets facing several significant threats including water extraction and regulation, land clearing and reclamation, and climate change. Classification and mapping of wetlands in agricultural landscapes is crucial for conserving these ecosystems to maintain their ecological integrity amidst ongoing land-use changes and environmental pressures. This study aims to establish a robust framework for wetland classification and mapping in intensive agricultural landscapes using time series of Sentinel-2 imagery, with a focus on the Gwydir Wetland Complex situated in the northern Murray–Darling Basin—Australia’s largest river system. Using the Google Earth Engine (GEE) platform, we extracted two groups of predictors based on six vegetation indices time series calculated from multi-temporal Sentinel-2 surface reflectance (SR) imagery: the first is statistical features summarizing the time series and the second is phenological features based on harmonic analysis of time series data (HANTS). We developed and evaluated random forest (RF) models for each level of classification with combination of different groups of predictors. Our results show that RF models involving both HANTS and statistical features perform strongly with significantly high overall accuracy and class-weighted F1 scores (p < 0.05) when comparing with models with either statistical or HANTS variables. While the models have excellent performance (F-score greater than 0.9) in distinguishing wetlands from other landcovers (croplands, terrestrial uplands, and open waters), the inter-class discriminating power among wetlands is class-specific: wetlands that are frequently inundated (including river red gum forests and wetlands dominated by common reed, water couch, and marsh club-rush) are generally better identified than the ones that are flooded less frequently, such as sedgelands and woodlands dominated by black box and coolabah. This study demonstrates that HANTS features extracted from time series Sentinel data can significantly improve the accuracy of wetland mapping in highly fragmentated agricultural landscapes. Thus, this framework enables wetland classification and mapping to be updated on a regular basis to better understand the dynamic nature of these complex ecosystems and improve long-term wetland monitoring.
Making Typicality: The Birth and Rebirth of the Torta Mattone of Bressana Bottarone, Italy
Authors: Fontefrancesco Michele Filippo
Published: May 2024

This article addresses the concept of “typicality” in community products, proposing a performative interpretation of this category. It ethnographically demonstrates how identifying products as “typical” is a process that involves a community in constructing both the product and its meaning. To illustrate this, this study delves into the case of Torta Mattone from Bressana Bottarone (PV) and its history. It highlights how, over 50 years, this dessert has been created and recreated as a symbol of the community in response to the pressing needs it faced amidst socio-economic changes. In doing so, this paper details its micro-gastronomic history, illustrating how the Torta Mattone has become instrumental in maintaining the social and cultural cohesion of the Oltrepo Pavese area.
Growth Responses of Holcus lanatus L. (Velvet Grass) in Soils Contaminated with Cesium or Strontium
Authors: Khan Bayezid M. , Alam M. Ferdous , Begum Zinnat A. , Rahman Ismail M. M.
Published: May 2024

Radiocesium (r-Cs) and radiostrontium (r-Sr) released from nuclear accidents (e.g., Chornobyl, Fukushima) and routine operations (reactors, reprocessing) pose environmental and health concerns. Their primary pathway to humans is through plant uptake and subsequent bioaccumulation within the food chain. While soil amendments with potassium (K) and calcium (Ca) are known to mitigate r-Cs and r-Sr uptake, respectively, the impact on plant growth remains unclear. This study investigates the effects of Cs and Sr on the growth of Holcus lanatus L. seedlings under hydroponic and soil conditions with varying Cs and Sr concentrations. Stable isotopes of Cs and Sr served as non-radioactive analogs. Seedling growth was assessed across a range of Cs and Sr concentrations (≤1 and ≥4 mg L−1). The impact of the addition of K and Ca on Cs/Sr uptake in amended soils was also evaluated. Additionally, this study examined how Cs and Sr amendments affected the influx rates of other nutrients in H. lanatus. Higher Cs and Sr concentrations (≥4 mg L−1) significantly inhibited seedling growth, while lower concentrations had no effect. Notably, H. lanatus exhibited moderate Cs tolerance and strong Sr tolerance. Furthermore, K and Ca supplementation in Cs/Sr-amended soils demonstrably reduced plant uptake of these elements. This study also observed alterations in the uptake rates of other nutrients within H. lanatus due to Cs/Sr addition. This study suggests that H. lanatus exhibits moderate tolerance to Cs and Sr contamination, potentially making it suitable for revegetation efforts in contaminated grasslands. Additionally, K and Ca amendments show promise as a strategy to mitigate plant uptake of these radioisotopes further. These findings contribute to the development of safer revitalization strategies for areas impacted by nuclear accidents.
A Systemic Approach to the Product Life Cycle for the Product Development Process in Agriculture
Authors: Lourenço Franciele , Gonçalves Marcelo Carneiro , Canciglieri Júnior Osiris , Dias Izamara Cristina Palheta , Benitez Guilherme Brittes , Benitez Lisianne Brittes , Nara Elpidio Oscar Benitez
Published: May 2024

For a long time, a company’s Product Development Process (PDP) was seen as supporting the operations department, although PDP decisions and mistakes have a considerable impact on market performance. This is critical even in agriculture where bad habits and practices in the PDP can lead rural producers to great losses. Therefore, this research investigates the effect of the PDP on the market performance of rural products (bananas) in the southern region of Brazil, based on two analyses: (i) how sustainability practices support the PDP phases and (ii) how the phases of the Product Life Cycle Assessment (LCA) mediate sustainability practices and PDP phases. This study presents a quantitative analysis using Confirmatory Factor Analysis (CFA) and hierarchical ordinary least squares (OLS) regression of data obtained from a survey of 110 rural producers who directly participate in the banana production and planning process in southern Brazil. Our results show that sustainability practices support the PDP, and we confirm that the product development and post-development phase has an effect on market performance. In addition, we identify that in the pre-development phase of the PDP, dealing with rural products (bananas), the maturity stage of the LCA mediates sustainability. In the PDP development phase, we conclude that rural families who develop economic and environmental practices with their products, which are in the market growth phase may have reduced results. As for the post-development phase of the PDP, we conclude that when companies invest in environmental and social practices, there is a complete mediation of the effect, where these practices lose strength if the product is in the introductory and maturity phases in the market. In an original matter, our study contributes to demonstrating the value of the product life cycle for the Product Development Process in agriculture using sustainability practices through a systemic approach, filling the gap in the literature due to a lack of integrated research on these areas seen.
Primary Energy and Carbon Impacts of Structural Frames with Equivalent Design Criteria: Influence of Different Materials and Levels of Prefabrication
Authors: Piccardo Chiara , Steinik Camille , Caffè Simone , Argentoni Alessio , Calderini Chiara
Published: May 2024

This study aims to analyze the life-cycle primary energy and climate impacts of structural frames, paying particular attention to the design and prefabrication of different structural materials. The study considers an existing single-story office building with a composite concrete–steel structure and compares it with two functionally equivalent structures, i.e., a conventional reinforced concrete structure and a conventional steel structure. The existing building is located in San Felice sul Panaro, Italy. This study integrates dynamic structural analysis and life-cycle assessment (LCA). The study finds that the use of different materials can reduce the life-cycle primary energy use and CO2-eq emissions by up to 12%. Furthermore, the benefits derived from the recovery and recycling of materials can reduce the primary energy use and CO2-eq emissions by up to 47% and 36%, respectively. The prefabrication of structural elements can also reduce the primary energy use and CO2-eq emissions in the construction stage. A sensitivity analysis considers changes in the electricity supply system and shows that the primary energy and CO2-eq emissions due to prefabrication decrease when assuming marginal electricity based on renewable energies. This analysis supports the development of sustainable structural design to meet the standards concerning the whole-life-cycle carbon emissions of buildings.
Impact of Anthropomorphic Design on User Sentiment and Sustained Use Intention towards Household Healthcare
Authors: Feng Qiaoyu , Cheng Si , Meng Hu
Published: May 2024

Although the household healthcare system is one of the cutting-edge application areas of anthropomorphic design, it remains to be further explored whether anthropomorphism is always effective. This article focuses on the context of aging-friendly household healthcare services and explores how anthropomorphic design affects users’ sustained use intention through sentiment feedback mechanisms. With the help of questionnaire surveys, 511 valid samples were randomly collected for empirical analysis and hypothesis testing. The results showed that positive interactions, cultural backgrounds, and appearance could enhance users’ perception of anthropomorphism from large to small. In addition, the positive (negative) sentiment of users plays a positive (negative) full mediating role in the relationship between anthropomorphic design and sustained use intention, and user technology anxiety moderates such relationships. That is, compared to low-level technology anxiety, in high-level states, anthropomorphic design for household healthcare systems and products has a weaker (stronger) positive (negative) effect on sustained use intention through positive (negative) emotions.
The Possibility and Improvement Directions of Achieving the Paris Agreement Goals from the Perspective of Climate Policy
Authors: Huang Zhihao , Huang Yujun , Zhang Shuaishuai
Published: May 2024

Currently, climate change and global warming have significantly impacted human life. In the context of sustainable development, achieving the goals of the Paris Agreement is both urgent and complex. This paper presents a comprehensive review of climate policies worldwide. Based on the global comprehensive climate policy database that we constructed and using global panel data from 1990 to 2019, we predicted the emission reduction due to climate policies using trend and fixed-effects models to identify areas for improvement. The research findings indicate that there is a considerable gap between current climate policies and the targets set by the Paris Agreement, both in terms of quantity and effectiveness. Economic growth and primary energy consumption contribute to increased greenhouse gas emissions, while increasing the proportion of renewable energy in electricity generation and implementing climate policies have the effect of reducing greenhouse gas emissions. Relying solely on increasing the quantity or effectiveness of policies would require an increase of 15–30 times the levels seen before 2019 to achieve the 2 °C warming target of the Paris Agreement. However, simultaneously increasing the number of policy implementations and enhancing their effectiveness would only require about a fourfold increase from the levels seen before 2019. Additionally, the results of the study on national heterogeneity demonstrate significant differences in policy effectiveness among countries, indicating substantial potential for emission reduction. Furthermore, the analysis of policy legal enforceability shows that hard law policies outperform soft law policies, suggesting that increasing the implementation of hard law policies can more effectively reduce emissions.
Sustainability Indicators for Dairy Cattle Farms in European Union Countries: A Systematic Literature Review
Authors: Pavanello Cristina , Franchini Marcello , Bovolenta Stefano , Marraccini Elisa , Corazzin Mirco
Published: May 2024

The European cattle milk sector has rapidly intensified in recent decades. This trend has received widespread disapproval from the public, which highlights the many problems linked to intensification. To address these concerns, agricultural policies commonly impose an agroecological transition. In order to evaluate and monitor the degree of sustainability of dairy cattle farms over time, many sets of indicators have been proposed in recent years. However, these indicators have often referred only to specific aspects of sustainability or have been generically proposed for the entire agricultural sector, and therefore, they are not capable of capturing the peculiarities and the complexity of the dairy cattle sector. A systematic review of the scientific literature was carried out to obtain a complete picture of the indicators proposed for the European context. A total of 325 out of over 6700 papers were selected, and three pillars—environmental, economic, and social pillars—were explored. A total of 70 indicators were identified, which could help build a complete and less sectoral picture of sustainability than that proposed so far. A total of 22 indicators were associated with the environmental pillar, 18 indicators were associated with the economic pillar, and 17 indicators were associated with the social pillar, while 12 indicators were associated with two different pillars. With reference to the measurement methods, considerable variability was highlighted, which did not allow us to identify or propose unique methods for measuring each indicator.