bluuebunny/crossref_metadata_2025 huggingface dataset:
Tourism commercialisation and the frontstage-backstage metaphor in intangible cultural heritage tourism
Authors: Wang Chujun , Wang Yali , Edelheim Johan Richard , Zhou Jianhong
Published: May 2024

Resolving tensions between tourism commercialisation and intangible cultural heritage (ICH) safeguarding is an important objective. Using the frontstage-backstage metaphor as an analytical lens, we investigate how tourism promotes ICH safeguarding and how detrimental aspects of tourism commercialisation can be handled in Miao silverware tourism in Fenghuang, China. Results show that tourism commercialisation is beneficial because it provides new possibilities and promotes the transformation of ICH. However, fake ICH products are detrimental, prioritising commercial value over ICH value. ICH inheritors create two separate commercial spaces to handle the segmented tourism market. The frontstage-backstage metaphor helps to investigate the transformational process of ICH in tourism and socio-psychological dilemmas of cultural practitioners in dealing with the multiplying realities of ICH.
Cost and non-cost factors associated with delays in receiving medical care in adults with atherosclerotic cardiovascular disease
Authors: Mszar Reed , Hagan Kobina , Lahan Shubham , Parekh Tarang
Published: May 2024

Background:

The study aims to compare cost and non-cost factors associated with delays in receiving medical care in adults with atherosclerotic cardiovascular disease (ASCVD).

Methods:

Using 2014–2018 data from the Centers for Disease Control and Prevention (CDC) Behaviour Risk Factor Surveillance System (BRFSS) survey ( N = 508,203), multivariate logistic regression models were developed to compute the adjusted odds ratio of reasons for delays in medical care in adults with ASCVD.

Results:

Our study population of 61,227 adults with ASCVD (9.1%) had higher odds of any medical care delay (aOR 1.50, 95% CI 1.43–1.57), delay due to cost (aOR 1.55, 95% CI 1.45–1.65), long clinic wait times (aOR 1.21, 95% CI 1.04–1.39) and lack of transportation (aOR 1.64, 95% CI 1.47–1.84) than those without ASCVD.

Conclusion:

Novel public health and health policy approaches are urgently needed to reduce the cost- and non-cost-related barriers that adults with ASCVD encounter when accessing healthcare services.
Role of Ti element in the microstructure and corrosion behavior of nickel-based alloy 825
Authors: Fan Jiajun , Dong Lijin , Zheng Huaibei , Wang Qinying , Li Liu , He Yi
Published: May 2024

The influence of Ti content on the microstructure and corrosion behavior of nickel-based alloy 825 in acid oil and gas environments was studied. The pitting corrosion behavior and stress corrosion cracking (SCC) behavior of Alloy 825 were investigated using high-temperature and high-pressure immersion tests, electrochemical tests, and slow strain rate tensile tests. Scanning electron microscopy, electron backscatter diffraction, and 3D microscopy were applied to analyze the microstructure and corrosion performance of the samples. The results showed that the number of inclusions and residual strain increased with the increase of Ti content, and strain concentration was found around the inclusions. The rise in inclusions led to lower pitting potential and a narrower passivation interval. In addition, the enhanced SCC susceptibility of the alloy with higher Ti content may also be attributed to the increase in inclusions.
Incidence, Predictors, and Implications of Secondary Aortic Intervention Following Thoracic Endovascular Aortic Repair for Type B Dissection
Authors: Wang Jizhong , Hu Xiaolu , Liu Jie , Liu Jitao , Li Ting , Huang Jing , Yang Yi , Fan Ruixin , Yang Fan , Luo Songyuan , Li Jie , Chen Zhengbo , Luo Jianfang
Published: May 2024

Background:

Secondary aortic intervention (SAI) following thoracic endovascular aortic repair (TEVAR) is not uncommon. However, a satisfactory management system has not been established for these patients. We aimed to report our single-center experience with SAI after prior TEVAR for type B aortic dissection (TBAD).

Methods:

From January 2010 to May 2017, 860 eligible patients with TBAD underwent TEVAR. One hundred seven (12.4%) patients required SAI, either endovascularly (n=76) or surgically (n=31). The main indications for SAI were entry flow (n=58 [54.2%]), aneurysm expansion of the proximal or remote aorta (n=26 [24.3%]), retrograde type A aortic dissection (n=11 [10.3%]), distal stent-graft–induced new entry tear (n=6 [5.6%]), and stent migration (n=4 [3.7%]). The Kaplan-Meier curves were generated to determine the degree of freedom from SAI and the prognosis. Cox proportional hazards were used to screen for risk factors for SAI and poor prognosis.

Results:

The overall 30-day mortality rate after SAI was 4.7% (n=5): endovascular (n=2 [2.6%]) vs open surgery (n=3 [9.7%]; p=0.145). The cumulative survival rates with or without SAI were 86.3%±3.6% vs 95.7%±0.8% at 3 years and 82.0%±4.2% vs 92.2%±1.1% at 5 years, respectively (log-rank p<0.001). Although no significant difference in survival was observed, the incidence of SAI was significantly greater in patients who underwent TEVAR during the chronic phase (acute [11.6%] vs subacute [9.6%] vs chronic [27.8]; p<0.001). Multivariate regression analysis revealed that prior TEVAR in the chronic phase (hazard ratio [HR]=1.73, 95% confidence interval [CI]=1.03-2.90; p=0.039), maximum aortic diameter (HR=1.05, 95% CI=1.04-1.07; p<0.001), and arch involvement (HR=1.48, 95% CI=1.01-2.18; p=0.048) were predictors of the incidence of SAI. In addition, the maximum aortic diameter was demonstrated to be the only risk factor for prognosis after adjusting for confounding factors.

Conclusions:

Thoracic endovascular aortic repair for chronic TBAD patients should be reconsidered. Open surgery is preferable for those with proximal progression, whereas endovascular treatment is more suitable for distal lesions. Close surveillance and timely reintervention after TEVAR, whether via endovascular techniques or open surgery, are necessary to prevent devastating complications.

Clinical Impact

The management of patients with type B aortic dissection (TBAD) after thoracic endovascular aortic repair (TEVAR) is challenging. We summarized our single-center experience regarding secondary aortic intervention after TEVAR for TBAD. We found that TEVAR for chronic TBAD patients should be carefully evaulated, and open surgery is recommended for those with proximal progession, while endovascular treatment is more preferable for distal lesions.
Efficacy of Lenvatinib in Combination With PD-1 Monoclonal Antibody and Interventional Treatment for Intermediate-Stage Hepatocellular Carcinoma: Impact on Serum Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 Levels: A Retrospective Study
Authors: Zhu Jianyong , Wu Yintao , Zhang Hong , Yang Jian , An Yang , Shao Shihan , Xia Nianxin
Published: May 2024

Objectives: To scrutinize the therapeutic efficiency and safety profile of lenvatinib, accompanied by the programmed cell death protein-1 (PD-1) monoclonal antibody, and interventional treatment in managing intermediate-stage hepatocellular carcinoma. Methods: Retrospective analysis was performed on clinical data from 93 patients suffering from intermediate to advanced hepatocellular carcinoma, treated at our institution from May 2018 to April 2020. Patients were divided based on the therapeutic regimen: 43 cases constituted the control group receiving lenvatinib plus transhepatic artery chemoembolization (TACE), while the remaining 50 cases in the study group were managed with lenvatinib, PD-1 monoclonal antibody, and TACE. Outcome measures included therapeutic efficacy, tumor markers (carcinoembryonic antigen [CEA], alpha-fetoprotein [AFP], α-L-fucosidase [AFU], carbohydrate antigen 199 [CA199]), immune response indices (CD3+, CD4+, CD8+, CD4+/CD8+ ratio), pertinent cytokine levels (vascular endothelial growth factor [VEGF], matrix metalloproteinase-9 [MMP-9], basic fibroblast growth factor [aFGF], acidic fibroblast growth factor [bFGF]), quality of life (as per Quality of Life Assessment Scale for Cancer Patients [QOL-LC] scores), adverse effects, and survival rates. Results: The study group exhibited a significantly enhanced total effective rate compared to the control group (74.00% vs 53.49%, P < .05). Post-treatment levels of CEA, AFP, AFU, CA199, CD8+, VEGF, MMP-9, aFGF, and bFGF were notably lower in both groups, particularly in the study group. Contrastingly, CD3+, CD4+, CD4+/CD8+ratios, and QOL-LC scores were substantially elevated in the study group ( P < .05). Adverse reaction prevalence was analogous between 2 groups (27.91% vs 26.00%; P > .05). Moreover, the study group reported significantly higher 1-, 2-, and 3-year survival rates than the control group ( P < .05). Conclusion: The combined use of lenvatinib, PD-1 monoclonal antibody, and interventional treatment for intermediate to advanced hepatocellular carcinoma may have a definitive therapeutic efficacy. This regimen is effective in reducing tumor marker levels, enhancing immune function, modulating VEGF, MMP-9, and other related cytokine levels, and improving patients’ quality of life without significantly augmenting adverse effects. This treatment paradigm also contributes to increased survival rates and promises favorable prognosis.
An interactive gesture control system for collaborative manipulator based on Leap Motion Controller
Authors: Li Yunhan , Lou Jingjing , Cai Zhiduan , Zheng Pengfei , Wu Haijun , Wang Xiaosun
Published: May 2024

Gesture control is often used for the control of robotic manipulators. However conventional methods always focus on position control of robotic manipulators and use a fixed position to place gesture detection devices, which limits the flexibility to control and interact. This paper presents an interactive gesture control system based on Leap Motion Controller that can overcome these shortcomings. A coordinate transformation is performed between the position of the left palm detected by Leap Motion Controller and the tool center point (TCP) of the collaborative manipulator to obtain gesture data first. This gesture data is used to control the posture of a six-joint collaborative manipulator-Lite6. The position of gripper is controlled by grip level of the right palm. A controller is designed to manipulate a lift table on which Leap Motion Controller is placed to achieve adaptive ascending and descending movements to meet the needs of operators of different heights and arm spans. A modified Kalman filter is used to filter noise and smooth the signal captured by Leap Motion Controller. The experiments demonstrate that the system can operate stably and accurately control the position, posture, and gripper position of a collaborative manipulator in real time using human palms’ gestures.
Identification of dynamic coefficients of gas foil bearings by simulated excitation based on coupled fields
Authors: Cheng Wenjie , Zhu Yuming , Ke Hanzhang , Xiao Ling , Li Ming , Feng Sheng , Xu Guohui
Published: May 2024

The dynamic coefficients (dynamic stiffness coefficient and dynamic damping coefficient) of gas foil bearings (GFBs) are important for transient dynamics calculation and stability analysis of the GFBs-rotor system. Although the perturbation method can be used to calculate the dynamic coefficients, it can only consider a single whirl ratio. Moreover, the whirl ratio is assumed and not practical. Therefore, this paper proposes an identification method of dynamic coefficients of GFBs by simulated excitation. Firstly, based on single journal-single GFB model considering gas-structure interaction by coupled fields, harmonic excitations were applied to the rotor to obtain the shaft orbit. Next, frequency response function method and equivalence coefficient method were used to identify dynamic coefficients. The former method is suitable for the case where response and excitation are same frequency, namely linear problem. The latter method is fit for the situation in which the response has multiple frequency components, namely nonlinear problem. Finally, examples were carried out, and the results from different methods were compared and analyzed. This research work lays a theoretical foundation for the design of the GFBs-rotor system.
Device-Related Skin Reactions Increase Emotional Burden in Youths With Type 1 Diabetes and Their Parents
Authors: Passanisi Stefano , Galletta Francesca , Bombaci Bruno , Cherubini Valentino , Tiberi Valentina , Minuto Nicola , Bassi Marta , Iafusco Dario , Piscopo Alessia , Mozzillo Enza , Di Candia Francesca , Rabbone Ivana , Pozzi Erica , Franceschi Roberto , Cauvin Vittoria , Maffeis Claudio , Piona Claudia Anita , Salzano Giuseppina
Published: May 2024

Background:

Skin reactions due to technological devices pose a significant concern in the management of type 1 diabetes (T1D). This multicentric, comparative cross-sectional study aimed to assess the psychological impact of device-related skin issues on youths with T1D and their parents.

Methods:

Participants with skin reactions were matched in a 1:1 ratio with a control group. Diabetes-related emotional distress was evaluated using the Problem Areas in Diabetes–Teen version (PAID-T) for participants aged 11 to 19 years and the Problem Areas in Diabetes–Parent Revised version (PAID-PR) completed by parents. In addition, glucose control was assessed through glycated hemoglobin (HbA1c) values and continuous glucose monitoring (CGM) metrics.

Results:

A total of 102 children and adolescents were consecutively recruited. Adolescents with skin issues had higher PAID-T scores compared to those without (79.6 ± 21.1 vs 62 ± 16.8; P = .004). Parents of youths with skin reactions also reported higher PAID-PR scores than the control group (34.0 ± 11.0 vs 26.9 ± 12.3; P = .015). No differences were observed in HbA1c levels (6.9 ± 0.8% vs 6.8 ± 0.8%, P = .555) or CGM glucose metrics between the two groups. Remarkably, 25.5% were forced to discontinue insulin pumps and/or glucose sensors (21.5% and 5.9%, respectively).

Conclusions:

Our study highlighted the increased emotional burden experienced by youths with T1D and their parents due to device-related skin reactions, emphasizing the need for further research and interventions in this crucial aspect of diabetes management.
Severe Insulin Pump-Related Adverse Events: Potential Root Causes and Impact of the COVID-19 Pandemic
Authors: Orbell Staci L. , Codario Ronald A. , Zupa Margaret F. , Estock Jamie L.
Published: May 2024

Objective:

To explore insulin pump-associated severe adverse events (SAEs) involving intensive care unit (ICU) admissions and deaths and examine the impact of the COVID-19 pandemic on these SAEs.

Methods:

Qualitative template analysis of narrative data in reported insulin pump-associated SAEs occurring between May 1, 2019, and January 31, 2021, involving MiniMed 670G, MiniMed 630G, Omnipod, Omnipod DASH, and t:slim X2 insulin pumps.

Results:

Over the 21-month measurement period, 460 SAEs involving an ICU admission and 288 SAEs involving a death were reported to the Food and Drug Administration. Problems with the pump or pod reservoir/cartridge were among the most frequently cited potential root causes in SAEs involving ICU admissions and deaths overall. However, problems with the infusion set or site and the pump battery or power emerged in the top three potential root causes of SAEs involving an ICU admission, whereas the patient sleeping at the time of the event and the tasks of changing the pod/infusion set, including reservoir/cartridge and programming the pump emerged in the top three for SAEs involving a death. The median monthly number of reported SAEs involving ICU admissions and deaths decreased during the pandemic, but their potential root causes were unchanged.

Conclusions:

Although insulin pumps are generally safe, SAEs related to their components and external factors can and do occur. By learning from the potential root causes of insulin pump-associated SAEs, providers and patients can implement corrective actions to prevent future events, thereby reducing harm.
Physical Therapy Intervention Effects on Alteration of Spinal Excitability in Patients With Chronic Ankle Instability: A Systematic Review and Meta-analysis
Authors: Lin Chia-Wei , Jankaew Amornthep , Lin Cheng-Feng
Published: May 2024

Context:

Chronic ankle instability (CAI) is a common injury in athletes. Different forms of physical therapy have been applied to the population with CAI to assess their impact on spinal excitability.

Objective:

The purpose of this systematic review and meta-analysis was to investigate the effectiveness of various physical therapy interventions on the alteration of spinal excitability in patients with CAI.

Data Sources:

Four databases (EMBASE, MEDLINE, Cochrane CENTRAL, and Scopus) were searched from inception to November 2022.

Study Selection:

A total of 253 studies were obtained and screened; 11 studies on the effects of physical therapy intervention on the alteration of spinal excitability in patients with CAI were identified for meta-analysis.

Study Design:

Systematic review and meta-analysis.

Level of Evidence:

Level 3a.

Data Extraction:

A total of 11 studies that included the maximal Hoffmann reflex normalized by the maximal muscle response (H/M ratio) in the peroneus longus and soleus muscles were extracted and summarized. The quality of the studies was assessed using the PEDro scale.

Results:

The extracted studies had an average PEDro score of 4.7 ± 1.4, indicating that most of them had fair-to-good quality. The physical therapy interventions included cryotherapy, taping, mobilization, proprioceptive training, and dry needling. The overall effects showed that the H/M ratios of the peroneus longus ( P = 0.44, I2 = 0%) and soleus ( P = 0.56, I2 = 22%) muscles were not changed by physical therapy in patients with CAI.

Conclusion:

The meta-analysis indicated that physical therapy interventions such as cryotherapy, taping, mobilization, proprioceptive training, and dry needling do not alter the spinal excitability in patients with CAI. Given that only 1 study reported ineffective changes in spinal excitability with dry needling, more research is essential to establish and validate its efficacy.

PROSPERO Registration:

CRD42022372998
Innovation and use of gamification in the enterprise—Selected cases
Authors: Singh Aditi , Bajpai Ashish
Published: May 2024

Enterprises facing escalating consumer switching and disenchantments are turning to innovative solutions for bringing about improved customer engagement. This in turn shall bring survival and growth in an environment of fierce competition. The present article explored the strategic adoption of gamification as a promising intervention to address the issue of customer engagement. Real-world cases from Indian enterprises, including Flipkart, Swiggy, Paytm, and Dream11, showcased how gamification enhances customer engagement and drives market disruption. These companies were selected based on their industry influence and innovative gamification strategies, drawing from secondary data sources. Utilizing multiple cases allows for a comprehensive analysis, offering broader insights beyond a single-case study approach. This case study encouraged the method of open discussion to identify the benefits and potential drawbacks of gamification interventions after going through the cases.
Behçet’s disease detecting by hemoptysis and recurrent epididymo-orchitis: A case report from Syria
Authors: Al Balkhi Abdulrahman , Berro Mohamad , Keieaty Sameh , Youssef Rahaf , Aboud Emad , Shmayyes Nour alhoda , Fandi Zain , Esmail Anan
Published: May 2024

Behçet’s disease is a chronic systemic inflammatory vasculitis of unknown etiology. It is characterized by recurrent episodes of oral aphthous ulcers, genital ulcers, skin lesions, ocular lesions, and other manifestations. This disease affects many organs and systems, showing a wide range of clinical features. Although pulmonary artery involvement is not common in Behçet’s disease, its presence carries a substantial risk of mortality. This report provides a detailed history of a 25-year-old male who was admitted with productive cough, hemoptysis, dyspnea on minimal exertion, fever, and chest pain. He had recurrent orchitis and epididymitis for 7 years, as well as oral and genital ulcers and severe headache. Clinical examination revealed decreased breath sounds at the right middle lung. Thoracic computed tomography angiography confirmed multiple pulmonary artery aneurysms bilaterally. The patient was diagnosed with Behçet’s disease, and immunosuppression therapy was initiated. During follow-up, the patient did not report any complications. This case report underscores the significance for clinicians to consider Behçet’s disease as a differential diagnosis in patients presenting with hemoptysis and a history of orchitis and epididymitis, given that Behçet’s disease rarely causes pulmonary artery aneurysms.
SVM-RLF-DNN: A DNN with reliefF and SVM for automatic identification of COVID from chest X-ray and CT images
Authors: Saha Sanjib , Nandi Debashis
Published: May 2024

Aim

To develop an advanced determination technology for detecting COVID-19 patterns from chest X-ray and CT-scan films with distinct applications of deep learning and machine learning methods.

Methods and Materials

The newly enhanced proposed hybrid classification network (SVM-RLF-DNN) comprises of three phases: feature extraction, selection and classification. The in-depth features are extracted from a series of 3×3 convolution, 2×2 max polling operations followed by a flattened and fully connected layer of the deep neural network (DNN). ReLU activation function and Adam optimizer are used in the model. The ReliefF is an improved feature selection algorithm of Relief that uses Manhattan distance instead of Euclidean distance. Based on the significance of the feature, the ReliefF assigns weight to each extracted feature received from a fully connected layer. The weight to each feature is the average of k closest hits and misses in each class for a neighbouring instance pair in multiclass problems. The ReliefF eliminates lower-weight features by setting the node value to zero. The higher weights of the features are kept to obtain the feature selection. At the last layer of the neural network, the multiclass Support Vector Machine (SVM) is used to classify the patterns of COVID-19, viral pneumonia and healthy cases. The three classes with three binary SVM classifiers use linear kernel function for each binary SVM following a one-versus-all approach. The hinge loss function and L2-norm regularization are selected for more stable results. The proposed method is assessed on publicly available chest X-ray and CT-scan image databases from Kaggle and GitHub. The performance of the proposed classification model has comparable training, validation, and test accuracy, as well as sensitivity, specificity, and confusion matrix for quantitative evaluation on five-fold cross-validation.

Results

Our proposed network has achieved test accuracy of 98.48% and 95.34% on 2-class X-rays and CT. More importantly, the proposed model's test accuracy, sensitivity, and specificity are 87.9%, 86.32%, and 90.25% for 3-class classification (COVID-19, Pneumonia, Normal) on chest X-rays. The proposed model provides the test accuracy, sensitivity, and specificity of 95.34%, 94.12%, and 96.15% for 2-class classification (COVID-19, Non-COVID) on chest CT.

Conclusion

Our proposed classification network experimental results indicate competitiveness with existing neural networks. The proposed neural network assists clinicians in determining and surveilling the disease.
The advantages, disadvantages, threats, and opportunities of electronic patient-reported outcome systems in cancer: A systematic review
Authors: Salmani Hosna , Nasiri Somayeh , Ahmadi Maryam
Published: May 2024

Objective

Electronic patient-reported outcome (ePRO) systems hold promise for revolutionizing communication between cancer patients and healthcare providers across various care settings. This systematic review explores the multifaceted landscape of ePROs in cancer care, encompassing their advantages, disadvantages, potential risks, and opportunities for improvement.

Methods

In our systematic review, we conducted a rigorous search in Scopus, Web of Science, and PubMed, employing comprehensive medical subject heading terms for ePRO and cancer, with no date limitations up to 2024. Studies were critically appraised and thematically analyzed based on inclusion and exclusion criteria, including considerations of advantages, disadvantages, opportunities, and threats.

Findings

Analyzing 85 articles revealed 69 themes categorized into four key areas. Advantages ( n = 14) were dominated by themes like “improved quality of life and care.” Disadvantages ( n = 26) included “limited access and technical issues.” Security concerns and lack of technical skills were prominent threats ( n = 10). Opportunities ( n = 19) highlighted advancements in symptom management and potential solutions for technical challenges.

Conclusion

This review emphasizes the crucial role of continuous exploration, integration, and innovation in ePRO systems for optimizing patient outcomes in cancer care. Beyond traditional clinical settings, ePROs hold promise for applications in survivorship, palliative care, and remote monitoring. By addressing existing limitations and capitalizing on opportunities, ePROs can empower patients, enhance communication, and ultimately improve care delivery across the entire cancer care spectrum.
Long-term efficacy and safety of rituximab in the treatment of neuromyelitis Optica Spectrum disorder
Authors: Hayes Michael T G , Adam Robert J , McCombe Pamela A , Walsh Michael , Blum Stefan
Published: May 2024

Background

Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, autoimmune, inflammatory astrocytopathy. Rituximab for B-cell suppression is a common treatment for NMOSD; however, large-scale randomised controlled trials are lacking.

Objective

Evaluate long-term efficacy and safety of rituximab for NMOSD.

Methods

Retrospective observational study of patients with NMOSD treated with rituximab. Annualised relapse rates (ARRs) before and during rituximab treatment were evaluated; Modified Rankin Scores (mRS) were measured as a marker of disability.

Results

In total, 37 patients were included: 27 aquaporin-4-IgG-seropositive and 10 seronegative NMOSD. The predominant rituximab dosing regimen was an initial 1000 mg, split over two 500 mg infusions, two weeks apart, followed by single 500 mg doses. Over a median follow-up of 54 months, ARR for the whole cohort was 0.136 (95% CI 0.088–0.201), significantly lower than the pretreatment ARR of 0.366 (95% CI 0.271–0.483, p < 0.001). There was a significant reduction in ARR for the seropositive subgroup, but not seronegative. Significant improvement in mRS was seen post-treatment. Infections were reported in 32% of patients during follow-up; most were mild.

Conclusion

Rituximab, at doses lower than traditionally used, may be an efficacious therapy for NMOSD, with a favourable safety profile.
A Research Paradigm of Weather Index Insurance for Grassland Animal Husbandry: A Pathway to Increased Income for Herders in China’s Inner Mongolia
Authors: Yufei Gong , Arshad Muhammad Umer , Xinya Guo , Xuguang Zhang , Yuanfeng Zhao
Published: May 2024

This paper aims to theoretically and empirically test whether the Weather Index Insurance for Mutton Sheep (WIMS) which protects the herders from increased feeding costs resulting from drought and snow disasters promotes the income of herders in China’s Inner Mongolia or not. We have applied the OLS, PSM, and quantile regression models using field survey data from 261 herders in Xilin Gol, Inner Mongolia Autonomous Region for our objective. The findings demonstrate that the WIMS significantly increases the overall and high-income herders’ income, but has no significant effect on herders’ income at other income levels.. According to the results, we recommend that as the subsidized agricultural insurance product, the government should expand the pilot region of WIMS to furtherly test its income effect and consider reducing or exempting insurance premiums for low-income herders to reduce their financial pressure.
Programs, Opportunities, and Challenges in Poverty Reduction: A Systematic Review
Authors: Ruja I Nyoman , Sumarmi  , Idris
Published: May 2024

Poverty has become the main focus of development in almost every country. Several related studies have discussed poverty alleviation recently, especially concerning the world’s pandemic phenomenon. This article aims to analyze the literature relating to programs, opportunities, and challenges in poverty alleviation in the world. PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) was used as a procedure for this systematic review. Twenty-two articles were selected as primary data collected from the Scopus and WoS database. Using thematic analysis, this study found that poverty alleviation programs are implemented in urban and rural areas and through women's empowerment. In addition, social, economic, and environmental benefits are determinant factors of the implications of poverty alleviation programs. One of the opportunities for poverty alleviation is to increase household income and create community welfare through empowering women. Meanwhile, the incompatibility of program targets, lack of funding, program synergy, gender gaps, and the environment are challenges for stakeholders that must be considered in the future. Recommendations and study implications of this study are also highlighted.
Humane Approach of e-learning Utilization: Case Study of Rolls-Royce
Authors: Naqvi Syed Rizwan , Sareen Puja , Sharma Tanuja , Naqvi Aiman
Published: May 2024

The primary goal of the case is to analyse how Rolls-Royce, a brand traditionally associated with extravagance, used its resources to make a substantial contribution to society during a global crisis. The research methodology for this case study included a case-based investigation of Rolls-Royce, an engineering business that has pioneered in power generation, aerospace and military. We split the research into two phases: identifying the hurdles to L&D practices and finding solutions. The exploratory study relies on secondary data sources such as websites, journals and research magazines. This approach supplements social capital theory to comprehensively understand how Rolls-Royce’s pandemic education programmes achieve their social commitments.
Computational approaches and challenges in the analysis of circRNA data
Authors: Digby Barry , Finn Stephen , Ó Broin Pilib
Published: May 2024

Circular RNAs (circRNA) are a class of non-coding RNA, forming a single-stranded covalently closed loop structure generated via back-splicing. Advancements in sequencing methods and technologies in conjunction with algorithmic developments of bioinformatics tools have enabled researchers to characterise the origin and function of circRNAs, with practical applications as a biomarker of diseases becoming increasingly relevant. Computational methods developed for circRNA analysis are predicated on detecting the chimeric back-splice junction of circRNAs whilst mitigating false-positive sequencing artefacts. In this review, we discuss in detail the computational strategies developed for circRNA identification, highlighting a selection of tool strengths, weaknesses and assumptions. In addition to circRNA identification tools, we describe methods for characterising the role of circRNAs within the competing endogenous RNA (ceRNA) network, their interactions with RNA-binding proteins, and publicly available databases for rich circRNA annotation.
Application of chitosan nanopriming on plant growth and secondary metabolites of Pancratium maritimum L
Authors: Allam Eman , El-Darier Salama , Ghattass Zekry , Fakhry Amal , Elghobashy Roufaida M.
Published: May 2024

Background

Nanotechnology has demonstrated its vital significance in all aspects of daily life. Our research was conducted to estimate the potential of primed seed with chitosan nanoparticles in seed growth and yield by inducing plant secondary metabolism of Pancratium maritimum L. one of the important medicinal plants. Petri dish and pot experiments were carried out. Seeds of Pancratium maritimum L. were soaked in Nano solution (0.1, 0.5, 1 mg/ ml) for 4, 8, 12 h. Germination parameters (germination percentage, germination velocity, speed of germination, germination energy, germination index, mean germination time, seedling shoot and root length, shoot root ratio, seedling vigor index, plant biomass and water content), alkaloids and antioxidant activity of Pancratium maritimum L. were recorded and compared between coated and uncoated seeds.

Results

Our results exhibited that chitosan nanopriming had a positive effect on some growth parameters, while it fluctuated on others. However, the data showed that most germination parameters were significantly affected in coated seeds compared to uncoated seeds. GC-MS analysis of Pancratium maritimum L. with different nanopriming treatments showed that the quantity of alkaloids decreased, but the amount of pancratistatin, lycorine and antioxidant content increased compared with the control.

Conclusions

Applying chitosan nanoparticles in priming seeds might be a simple and effective way to improve the quantity of secondary metabolites of Pancratium maritimum L. valuable medicinal plant.
Winter survival in red clover: experimental evidence for interactions among stresses
Authors: Ergon Åshild , Amdahl Helga
Published: May 2024

Background

There is a lack of knowledge on the combined effects of different stresses on plants, in particular different stresses that occur during winter in temperate climates. Perennial herbaceous plants in temperate regions are exposed to many different stresses during winter, but except for the fact that cold temperatures induce resistance to a number of them, very little is known about their interaction effects. Knowledge about stress interactions is needed in order to predict effects of climate change on both agricultural production and natural ecosystems, and to develop adaptation strategies, e.g., through plant breeding. Here, we conducted a series of experiments under controlled conditions to study the interactions between cold (low positive temperature), clover rot infection (caused by Sclerotinia trifoliorum) and freezing, in red clover (Trifolium pratense) accessions. We also compared our results with winter survival in field experiments and studied associations between stress and shoot growth.

Results

Exposure to low positive temperatures (cold acclimation) induced resistance to clover rot. There was a clear negative interaction effect between freezing stress and clover rot infection, resulting in up to 37% lower survival rate compared to what would have been expected from the additive effect of freezing and infection alone. Freezing tolerance could continue to improve during incubation under artificial snow cover at 3 °C in spite of darkness, and we observed compensatory shoot growth following freezing after prolonged incubation. At the accession level, resistance to clover rot was negatively correlated with growth in the field during the previous year at a Norwegian location. It was also negatively correlated with the shoot regrowth of control plants after incubation. Clover rot resistance tests under controlled conditions showed limited correlation with clover rot resistance observed in the field, suggesting that they may reveal variation in more specific resistance mechanisms.

Conclusions

We here demonstrate, for the first time, a strong negative interaction between freezing and infection with a winter pathogen. We also characterize the effects of cold acclimation and incubation in darkness at different temperatures on winter stress tolerance, and present data that support the notion that annual cycles of growth and stress resistance are associated at the genetic level.
Characteristics that increase the risk for pain on propofol injection
Authors: Leff Phillip J. , Dinner Brett A. , Chuang Keng-Yu , Leff David B.
Published: May 2024

Background

Propofol for anesthesia has become increasingly popular for endoscopic procedures. However, pain on propofol injection (POPI) remains an issue with administration. The primary endpoint of this study was to identify patient characteristics and factors, such as IV site and gauge, that could predict the occurrence of POPI.

Methods

This was a prospective chart review study of 291 patients undergoing endoscopic procedures. The patient’s demographics, intravenous (IV) site, and gauge were extrapolated. POPI was scored 0–3: 0 for no pain, 1 for minimal discomfort or awareness of sensation, 2 for discomfort but manageable/tolerable, and 3 for severe discomfort with writhing.

Results

291 patient charts were reviewed. One patient was excluded for a lower extremity IV site. 225 (77.6%) had no pain, 48 (16.6%) grade 1 pain, 16 (5.5%) grade 2 pain, and 1 (0.3%) grade 3 pain. 137, 13, and 140 patients respectively had antecubital (AC), forearm, and hand IVs. Zero patients with an AC IV experienced a score greater than 1. Compared to AC, forearm IVs with pain of 2–3 had a univariate odds ratio (OR) of 11.3 (0.66,1.92; p-value < 0.001), and hand IVs had a univariate OR of 18.8 (2.46,143.3; p-value < 0.001) with a multivariable OR 15.2 (1.93,118.9; p-value 0.004). Patients with anxiety/depression and pain had a univariate OR 2.31 (1.09, 7.27; p-value 0.031) with a multivariable OR 2.85 (1.06, 7.74; p-value 0.039). SSRI/SNRI use had a univariate OR 1.56 (0.57,4.28; p-value 0.38). Alcohol use had a univariate OR 1.24 (0.39,3.91; p-value 0.71). Narcotic use had a Univariate OR 6.18 (1.49,25.6; p-value 0.012). Diabetic patients had a univariate OR of 1.42 (0.45,4.48; p-value 0.55). Chronic pain had a univariate OR of 3.11 (1.04,9.28; p-value 0.042). Females had a univariate OR 0.98 (0.37,2.63; p-value 0.95).

Conclusion

This study identified potential characteristics for having POPI. The incidence of POPI was statistically significant in patients with hand and forearm IVs compared to AC IV sites, larger IV gauges, history of depression/anxiety, history of chronic narcotic use, fibromyalgia, and chronic pain syndromes. This shows the potential of premedicating with analgesics or using AC sites on these select patients to help reduce the risk of POPI.
Detection and diagnosis of automated breast ultrasound in patients with BI-RADS category 4 microcalcifications: a retrospective study
Authors: Yu Li-Fang , Dai Chao-Chao , Zhu Luo-Xi , Xu Xiao-Jing , Yan Hong-Ju , Jiang Chen-Xiang , Bao Ling-Yun
Published: May 2024

Background

Automated Breast Ultrasound (AB US) has shown good application value and prospects in breast disease screening and diagnosis. The aim of the study was to explore the ability of AB US to detect and diagnose mammographically Breast Imaging Reporting and Data System (BI-RADS) category 4 microcalcifications.

Methods

575 pathologically confirmed mammographically BI-RADS category 4 microcalcifications from January 2017 to June 2021 were included. All patients also completed AB US examinations. Based on the final pathological results, analyzed and summarized the AB US image features, and compared the evaluation results with mammography, to explore the detection and diagnostic ability of AB US for these suspicious microcalcifications.

Results

250 were finally confirmed as malignant and 325 were benign. Mammographic findings including microcalcifications morphology (61/80 with amorphous, coarse heterogeneous and fine pleomorphic, 13/14 with fine-linear or branching), calcification distribution (189/346 with grouped, 40/67 with linear and segmental), associated features (70/96 with asymmetric shadow), higher BI-RADS category with 4B (88/120) and 4 C (73/38) showed higher incidence in malignant lesions, and were the independent factors associated with malignant microcalcifications. 477 (477/575, 83.0%) microcalcifications were detected by AB US, including 223 malignant and 254 benign, with a significantly higher detection rate for malignant lesions (x2 = 12.20, P < 0.001). Logistic regression analysis showed microcalcifications with architectural distortion (odds ratio [OR] = 0.30, P = 0.014), with amorphous, coarse heterogeneous and fine pleomorphic morphology (OR = 3.15, P = 0.037), grouped (OR = 1.90, P = 0.017), liner and segmental distribution (OR = 8.93, P = 0.004) were the independent factors which could affect the detectability of AB US for microcalcifications. In AB US, malignant calcification was more frequent in a mass (104/154) or intraductal (20/32), and with ductal changes (30/41) or architectural distortion (58/68), especially with the both (12/12). BI-RADS category results also showed that AB US had higher sensitivity to malignant calcification than mammography (64.8% vs. 46.8%).

Conclusions

AB US has good detectability for mammographically BI-RADS category 4 microcalcifications, especially for malignant lesions. Malignant calcification is more common in a mass and intraductal in AB US, and tend to associated with architectural distortion or duct changes. Also, AB US has higher sensitivity than mammography to malignant microcalcification, which is expected to become an effective supplementary examination method for breast microcalcifications, especially in dense breasts.
Time to full enteral feeding and its predictors among very low birth weight (VLBW) neonates admitted to the neonatal intensive care units (NICU) in comprehensive specialized hospitals in Northwest Ethiopia
Authors: Esubalew Hilena , Messelu Mengistu Abebe , Tarekegn Bethelihem Tigabu , Admasu Aster Tefera , Abrha Nega Nigussie , Terefe Bewuketu
Published: May 2024

Background

Time to full enteral feeding is the time when neonates start to receive all of their prescribed nutrition as milk feeds. Delayed to achieve full enteral feeding had resulted in short- and long-term physical and neurological sequelae. However, there are limited studies to assess the time to full enteral feeding and its predictors among very low birth-weight neonates in Ethiopia. Therefore, this study aimed to assess the time to full enteral feeding and its predictors among very low birth-weight neonates admitted to comprehensive specialized hospitals in Northwest Ethiopia.

Methods

A multi-center institutional-based retrospective follow-up study was conducted among 409 VLBW neonates from March 1, 2019 to February 30, 2023. A simple random sampling method was used to select study participants. Data were entered into EpiData version 4.2 and then exported into STATA version 16 for analysis. The Kaplan–Meier survival curve together with the log-rank test was fitted to test for the presence of differences among groups. Proportional hazard assumptions were checked using a global test. Variables having a p- value < 0.25 in the bivariable Cox-proportional hazard model were candidates for multivariable analysis. An adjusted Hazard Ratio (AHR) with 95% Confidence Intervals (CI) was computed to report the strength of association, and variables having a P-value < 0.05 at the 95% confidence interval were considered statistically significant predictor variables.

Result

The median time to full enteral feeding was 10 (CI: 10–11) days. Very Low Birth-Weight (VLBW) neonates who received a formula feeding (AHR: 0.71, 95% CI: 0.53, 0.96), gestational age of 32–37 weeks (AHR: 1.66, 95% CI: 1.23, 2.23), without Necrotizing Enterocolitis (NEC) (AHR: 2.16, 95% CI: 1.65, 2.84), and single birth outcome (AHR: 1.42, 95% CI: 1.07, 1.88) were statistically significant variables with time to full enteral feeding.

Conclusion and recommendations

This study found that the median time to full enteral feeding was high. Type of feeding, Necrotizing Enterocolitis (NEC), Gestational Age (GA) at birth, and birth outcome were predictor variables. Special attention and follow-up are needed for those VLBW neonates with NEC, had a GA of less than 32 weeks, and had multiple birth outcomes.
Application of 3D printing surgical training models in the preoperative assessment of robot-assisted partial nephrectomy
Authors: Wang Zheng , Wang Xin Yu , Yu Xiao fen
Published: May 2024

Background

To explore the application effect of 3D printing surgical training models in the preoperative assessment of robot-assisted partial nephrectomy.

Methods

Eighty patients who underwent robot-assisted partial nephrectomy surgery between January 2022 and December 2023 were selected and divided into two groups according to the chronological order. The control group (n = 40) received preoperative assessment with verbal and video education from January 2022 to December 2022, while the observation group (n = 40) received preoperative assessment with 3D printing surgical training models combined with verbal and video education from January 2023 to December 2023. The preoperative anxiety, information demand score, and surgical awareness were compared between the two groups. The physiological stress indicators, including interleukin-6 (IL-6), angiotensin II (AT II), adrenocorticotropic hormone (ACTH), cortisol (Cor), mean arterial pressure (MAP), and heart rate (HR), were also measured at different time points before and after surgery.They were 6:00 am on the day before surgery (T0), 6:00 am on the day of the operation (T1), 6:00 am on the first day after the operation (T2), and 6:00 am on the third day after the operation (T3).The preparation rate before surgery was compared between the two groups.

Results

The anxiety and surgical information demand scores were lower in the observation group than in the control group before anesthesia induction, and the difference was statistically significant (P < 0.001). Both groups had lower scores before anesthesia induction than before preoperative assessment, and the difference was statistically significant (P < 0.05). The physiological stress indicators at T1 time points were lower in the observation group than in the control group, and the difference was statistically significant (P < 0.05). The overall means of the physiological stress indicators differed significantly between the two groups (P < 0.001). Compared with the T0 time point, the T1, T2, and T3 time points in both groups were significantly lower, and the difference was statistically significant (P < 0.05). The surgical awareness and preparation rate before surgery were higher in the observation group than in the control group, and the difference was statistically significant (P < 0.05).

Conclusion

The preoperative assessment mode using 3D printing surgical training models combined with verbal and video education can effectively reduce the psychological and physiological stress responses of surgical patients, improve their surgical awareness, and enhance the preparation rate before surgery.