bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing Team Interactions in Traditional and BIM-Lean Design Management
Authors: Herrera Rodrigo F. , Mourgues Claudio , Alarcón Luis F. , Pellicer Eugenio
Published: September 2021

There is qualitative evidence showing that design teams that use BIM-lean management have a higher level of interaction than design teams that do not use this management approach. However, there is no quantitative empirical evidence of this higher level of interaction. Therefore, the objective of this paper is to present quantitative empirical evidence of the differences among the various types of interactions of a design team. Two case studies were analyzed, and their design management was assessed from a lean BIM perspective while their team interactions were assessed using social network analysis (SNA). To achieve the aim of this paper, four steps were performed: (1) case study selection; (2) description of the design management of the projects from the lean design management and BIM perspectives; (3) assessment of design team interaction; and (4) comparison using SNA. The results show that the project that applied BIM-lean management exhibited higher levels of interactions among its design team members than the traditional team; transparent, orderly, and standardized information flows; a collaborative, trusting, and learning environment; and commitment management. None of these interaction elements were visible in the project that did not apply BIM-lean management. It is suggested that an analysis be performed on a representative sample of projects in the future so that conclusive statistical inferences could be made.
Potential Therapeutic and Prognostic Values of LSM Family Genes in Breast Cancer
Authors: Ta Hoang Dang Khoa , Wang Wei-Jan , Phan Nam Nhut , An Ton Nu Thuy , Anuraga Gangga , Ku Su-Chi , Wu Yung-Fu , Wang Chih-Yang , Lee Kuen-Haur
Published: September 2021

In recent decades, breast cancer (BRCA) has become one of the most common diseases worldwide. Understanding crucial genes and their signaling pathways remain an enormous challenge in evaluating the prognosis and possible therapeutics. The “Like-Smith” (LSM) family is known as protein-coding genes, and its member play pivotal roles in the progression of several malignancies, although their roles in BRCA are less clear. To discover biological processes associated with LSM family genes in BRCA development, high-throughput techniques were applied to clarify expression levels of LSMs in The Cancer Genome Atlas (TCGA)-BRCA dataset, which was integrated with the cBioPortal database. Furthermore, we investigated prognostic values of LSM family genes in BCRA patients using the Kaplan–Meier database. Among genes of this family, LSM4 expression levels were highly associated with poor prognostic outcomes with a hazard ratio of 1.35 (95% confidence interval 1.21–1.51, p for trend = 3.4 × 10−7). MetaCore and GlueGo analyses were also conducted to examine transcript expression signatures of LSM family members and their coexpressed genes, together with their associated signaling pathways, such as “Cell cycle role of APC in cell cycle regulation” and “Immune response IL-15 signaling via MAPK and PI3K cascade” in BRCA. Results showed that LSM family members, specifically LSM4, were significantly correlated with oncogenesis in BRCA patients. In summary, our results suggested that LSM4 could be a prospective prognosticator of BRCA.
MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis
Authors: Pietrobono Silvia , Franci Lorenzo , Imperatore Francesco , Zanini Cristina , Stecca Barbara , Chiariello Mario
Published: September 2021

In medulloblastomas, genetic alterations resulting in over-activation and/or deregulation of proteins involved in Hedgehog (HH) signaling lead to cellular transformation, which can be prevented by inhibition of primary ciliogenesis. Here, we investigated the role of MAPK15 in HH signaling and, in turn, in HH-mediated cellular transformation. We first demonstrated, in NIH3T3 mouse fibroblasts, the ability of this kinase of controlling primary ciliogenesis and canonical HH signaling. Next, we took advantage of transformed human medulloblastoma cells belonging to the SHH-driven subtype, i.e., DAOY and ONS-76 cells, to ascertain the role for MAPK15 in HH-mediated cellular transformation. Specifically, medullo-spheres derived from these cells, an established in vitro model for evaluating progression and malignancy of putative tumor-initiating medulloblastoma cells, were used to demonstrate that MAPK15 regulates self-renewal of these cancer stem cell-like cells. Interestingly, by using the HH-related oncogenes SMO-M2 and GLI2-DN, we provided evidences that disruption of MAPK15 signaling inhibits oncogenic HH overactivation in a specific cilia-dependent fashion. Ultimately, we show that pharmacological inhibition of MAPK15 prevents cell proliferation of SHH-driven medulloblastoma cells, overall suggesting that oncogenic HH signaling can be counteracted by targeting the ciliary gene MAPK15, which could therefore be considered a promising target for innovative “smart” therapies in medulloblastomas.
Role of Resin Microsphere Y90 Dosimetry in Predicting Objective Tumor Response, Survival and Treatment Related Toxicity in Surgically Unresectable Colorectal Liver Metastasis: A Retrospective Single Institution Study
Authors: Sankhla Tina , Cheng Bernard , Nezami Nariman , Xing Minzhi , Sethi Ila , Bercu Zachary , Brandon David , Majdalany Bill , Schuster David M. , Kokabi Nima
Published: September 2021

Purpose: To Evaluate the correlation between tumor dosimetric parameters with objective tumor response (OR) and overall survival (OS) in patients with surgically unresectable colorectal liver metastasis (CRLM) undergoing resin-based Ytrrium-90 selective internal radiation therapy (Y90 SIRT). Materials and Methods: 45 consecutive patients with CRLM underwent resin-based Y90 SIRT in one or both hepatic lobes (66 treated lobes total). Dose volume histograms were created with MIM Sureplan® v.6.9 using post-treatment SPECT/CT. Dosimetry analyses were based on the cumulative volume of the five largest tumors in each treatment session and non-tumoral liver (NTL) dose. Receiver operating characteristic (ROC) curve was used to evaluate tumor dosimetric factors in predicting OR by Response Evaluation Criteria for Solid Tumors at 3 months post-Y90. Additionally, ROC curve was used to evaluate non-tumoral liver dose as a predictor of grade ≥ 3 liver toxicity and radioembolization induced liver disease (REILD) 3 months post Y90. To minimize for potential confounding demographic and clinical factors, univariate and multivariate analysis of survival with mean tumor dose as one of the factors were also performed. Kaplan-Meier estimation was used for OS analysis from initial Y90 SIRT. Results: 26 out of 45 patients had OR with a median OS of 17.2 months versus 6.8 months for patients without OR (p < 0.001). Mean tumor dose (TD) of the five largest tumors was the strongest predictor of OR with an area under the curve of 0.73 (p < 0.001). Minimum TD, and TD to 30%, 50%, and 70% of tumor volume also predicted OR (p’s < 0.05). Mean TD ≥ 100 Gy predicted a significantly prolonged median OS of 19 vs. 11 months for those receiving TD < 100 Gy (p = 0.016). On univariate analysis, mean TD < 100 Gy, presence of any genomic mutation, presence of MAPK pathway mutation, bilobar hepatic metastases and diffuse metastatic disease (>10 lesions per liver lobe) were found to be predictors of shorter median OS. On multivariate analysis, mean TD < 100 Gy, presence of any genomic mutation, and diffuse hepatic metastatic disease were found to be independent predictors of shorter OS. Overall, six (13.3%) patients developed grade ≥ 3 liver toxicity post Y90 of whom two (4.4%) patients developed REILD. No dose threshold predicting grade ≥ 3 liver toxicity or REILD was identified. Conclusions: Mean TD ≥ 100 Gy in patients with unresectable CRLM undergoing resin-based Y90 SIRT predicts OR and prolonged OS.
Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group
Authors: Van Bockstal Mieke R. , Cooks Maxine , Nederlof Iris , Brinkhuis Mariël , Dutman Annemiek , Koopmans Monique , Kooreman Loes , van der Vegt Bert , Verhoog Leon , Vreuls Celine , Westenend Pieter , Kok Marleen , van Diest Paul J. , Nauwelaers Inne , Laudus Nele , Denkert Carsten , Rimm David , Siziopikou Kalliopi P. , Ely Scott , Zardavas Dimitrios , Roberts Mustimbo , Floris Giuseppe , Hartman Johan , Acs Balazs , Peeters Dieter , Bartlett John M.S. , Dequeker Els , Salgado Roberto , Giudici Fabiola , Michiels Stefan , Horlings Hugo , van Deurzen Carolien H. M.
Published: September 2021

Patients with advanced triple-negative breast cancer (TNBC) benefit from treatment with atezolizumab, provided that the tumor contains ≥1% of PD-L1/SP142-positive immune cells. Numbers of tumor-infiltrating lymphocytes (TILs) vary strongly according to the anatomic localization of TNBC metastases. We investigated inter-pathologist agreement in the assessment of PD-L1/SP142 immunohistochemistry and TILs. Ten pathologists evaluated PD-L1/SP142 expression in a proficiency test comprising 28 primary TNBCs, as well as PD-L1/SP142 expression and levels of TILs in 49 distant TNBC metastases with various localizations. Interobserver agreement for PD-L1 status (positive vs. negative) was high in the proficiency test: the corresponding scores as percentages showed good agreement with the consensus diagnosis. In TNBC metastases, there was substantial variability in PD-L1 status at the individual patient level. For one in five patients, the chance of treatment was essentially random, with half of the pathologists designating them as positive and half negative. Assessment of PD-L1/SP142 and TILs as percentages in TNBC metastases showed poor and moderate agreement, respectively. Additional training for metastatic TNBC is required to enhance interobserver agreement. Such training, focusing on metastatic specimens, seems worthwhile, since the same pathologists obtained high percentages of concordance (ranging from 93% to 100%) on the PD-L1 status of primary TNBCs.
Transplant Oncology: An Evolving Field in Cancer Care
Authors: Abdelrahim Maen , Esmail Abdullah , Abudayyeh Ala , Murakami Naoka , Saharia Ashish , McMillan Robert , Victor David , Kodali Sudha , Shetty Akshay , Nolte Fong Joy V. , Moore Linda W. , Heyne Kirk , Gaber A. Osama , Ghobrial Rafik Mark
Published: September 2021

Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The application of oncology, transplant medicine, and surgery to improve patients’ survival and quality of life is the core of transplant oncology. Hepatobiliary malignancies have been treated by liver transplantation (LT) with significant improved outcome. In addition, as the liver is the most common site of metastasis for colorectal cancer (CRC), patients with CRC who have stable unresectable liver metastases are good candidates for LT, and initial studies have shown improved survival compared to palliative systemic therapy. The indications of LT for hepatobiliary malignancies have been slowly expanded over the years in a stepwise manner; however, they have only been shown to improve patient survival in the setting of limited systemic therapy options. This review illustrates the concept and history of transplant oncology as an evolving field for the management of hepatocellular carcinoma, intrahepatic biliary cancer, and liver-only metastasis of non-hepatobiliary carcinoma. The utility of immunotherapy in the transplant setting is discussed as well as the feasibility of using circulating tumor DNA for surveillance post-transplantation.
MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
Authors: Hirao Akihiro , Sato Yasushi , Tanaka Hironori , Nishida Kensei , Tomonari Tetsu , Hirata Misato , Bando Masahiro , Kida Yoshifumi , Tanaka Takahiro , Kawaguchi Tomoyuki , Wada Hironori , Taniguchi Tatsuya , Okamoto Koichi , Miyamoto Hiroshi , Muguruma Naoki , Tanahashi Toshihito , Takayama Tetsuji
Published: September 2021

The mechanism of resistance to sorafenib in hepatocellular carcinoma (HCC) remains unclear. We analyzed miRNA expression profiles in sorafenib-resistant HCC cell lines (PLC/PRF5-R1/R2) and parental cell lines (PLC/PRF5) to identify the miRNAs responsible for resistance. Drug sensitivity, migration/invasion capabilities, and epithelial-mesenchymal transition (EMT) properties were analyzed by biochemical methods. The clinical relevance of the target genes to survival in HCC patients were assessed using a public database. Four miRNAs were significantly upregulated in PLC/PRF5-R1/-R2 compared with PLC/PRF5. Among them, miR-125b-5p mimic-transfected PLC/PRF5 cells (PLC/PRF5-miR125b) and showed a significantly higher IC50 for sorafenib compared with controls, while the other miRNA mimics did not. PLC/PRF5-miR125b showed lower E-cadherin and higher Snail and vimentin expression—findings similar to those for PLC/PRF5-R2—which suggests the induction of EMT in those cells. PLC/PRF5-miR125b exhibited significantly higher migration and invasion capabilities and induced sorafenib resistance in an in vivo mouse model. Bioinformatic analysis revealed ataxin-1 as a target gene of miR-125b-5p. PLC/PRF5 cells transfected with ataxin-1 siRNA showed a significantly higher IC50, higher migration/invasion capability, higher cancer stem cell population, and an EMT phenotype. Median overall survival in the low-ataxin-1 patient group was significantly shorter than in the high-ataxin-1 group. In conclusion, miR-125b-5p suppressed ataxin-1 and consequently induced Snail-mediated EMT and stemness, leading to a poor prognosis in HCC patients.
Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis
Authors: Casadio Paolo , Raffone Antonio , Maletta Manuela , Travaglino Antonio , Raimondo Diego , Raimondo Ivano , Santoro Angela , Paradisi Roberto , Zannoni Gian Franco , Mollo Antonio , Seracchioli Renato
Published: September 2021

A better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been reported. Unfortunately, it is still unclear if this better prognosis is related to a more favorable clinical profile of adenomyosis patients. We aimed to evaluate differences in the clinical profiles of EC patients with and without adenomyosis. A systematic review and meta-analysis was performed by searching seven electronics databases for all studies that allowed extraction of data about clinical characteristics in EC patients with and without adenomyosis. Clinical characteristics assessed were: age, Body Mass Index (BMI), premenopausal status, and nulliparity. Mean difference in mean ± standard deviation (SD) or odds ratio (OR) for clinical characteristics between EC patients with and without adenomyosis were calculated for each included study and as a pooled estimate, and graphically reported on forest plots with a 95% confidence interval (CI). The Z test was used for assessing the overall effect by considering a p value < 0.05 as significant. Overall, eight studies with 5681 patients were included in the qualitative analysis, and seven studies with 4366 patients in the quantitative analysis. Pooled mean difference in mean ± SD between EC women with and without adenomyosis was −1.19 (95% CI: −3.18 to 0.80; p = 0.24) for age, and 0.23 (95% CI: −0.62 to 1.07; p = 0.60) for BMI. When compared to EC women without adenomyosis, EC women with adenomyosis showed a pooled OR of 1.53 (95% CI: 0.92 to 2.54; p = 0.10) for premenopausal status, and of 0.60 (95% CI: 0.41 to 0.87; p = 0.007) for nulliparity. In conclusion, there are not significant differences in clinical characteristics between EC patients with and without adenomyosis, with the exception for nulliparity. Clinical features seem to not underlie the better EC prognosis of patients with adenomyosis compared to patients without adenomyosis.
An Update on the Current Genomic Landscape of Breast Implant-Associated Anaplastic Large Cell Lymphoma
Authors: Harrop Sean , Mehta-Shah Neha , Dsouza Criselle , Thompson Ella , Deva Anand , Prince Henry Miles
Published: September 2021

Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell lymphoma associated with breast prostheses. Most patients present with a localised periprosthetic effusion and are managed with removal of the implant and surrounding capsule. Less commonly, the lymphoma can form a mass associated with the capsule and rarely can present with disseminated disease. Recent series characterising the genomic landscape of BIA-ALCL have led to insights into the mechanisms of lymphomagenesis. Constitutive JAK/STAT pathway activation has emerged as a likely key component while, more recently, aberrancies in epigenetic regulators have been reported. This review describes the genomic characterisation reported to date and the insight these findings have provided into this rare entity.
A New Paradigm in Managing Advanced Ovarian Cancer: Differentiating Patients Requiring Neoadjuvant Treatment from Primary Cytoreduction
Authors: Kraus Francois , El Hajj Houssein , Le Deley Marie-Cécile , Aissaoui Othman , Gachon Bertrand , Chevalier Annick , Abdeddaim Cyril , Lemaire Anne-Sophie , Ben Haj Amor Mariem , Sylla Dienabou , Leblanc Eric , Narducci Fabrice , Hudry Delphine
Published: September 2021

Our study aims to evaluate the comparability of primary debulking surgery (PDS) and neoadjuvant chemotherapy (NACT) patients. This single-center retrospective study includes all patients treated for advanced stages high-grade serous ovarian carcinomas (HGSOC) between 2007 and 2017. Preoperative characteristics and postoperative outcomes were compared after a propensity score matching analysis. Of the 221 patients included, 38% underwent PDS, and 62% received NACT. There was no age difference at diagnosis; however, CA125 levels, PCI score levels, and rates of stage IV were higher in the NACT group. There were no differences concerning the rate and the severity of complications (p = 0.29). The propensity score distribution showed a broad distinction between PDS patients and NACT patients with no significant overlap. Survival analyses demonstrate, after a median follow-up of 66.5 months, an overall survival (OS) of 105.9 and progression-free survival (PFS) of 29.2 months in the PDS group, compared to OS of 52.8 and PFS of 18.9 months in the NACT group. Advanced HGSOC is a heterogeneous population, in which inoperable patients should be differentiated from PDS patients based on many factors, primarily tumor burden.
Non-Solvent Synthesis of a Robust Potassium-Doped PdCu-Pd-Cu@C Nanocatalyst for High Selectively Tandem Reactions
Authors: Jang Sanha , Annas Dicky , Song Sehwan , Bae Jong-Seong , Park Sungkyun , Park Kang Hyun
Published: September 2021

A non-solvent synthesis of alkali metal-doped PdCu-Pd-Cu@C is presented that needs no mechanical grinding and utilizes heat treatment under an N2 gas flow. Pluronic® F127 is used to generate pores and a high surface area, and tannic acid is used as a carbon source for the PdCu-Pd-Cu@C nanocatalysts. Because some C is transferred to organic compounds during the nitrogen heat treatment, this demonstrated the advantage of raising the weight ratio of active metals comparatively. The PdCu-Pd-Cu@C nanocatalyst developed in this study outperformed commercial Pd/C catalysts by bimetallic PdCu-Pd-Cu nanoparticles and Pd nanoparticles in terms of catalytic activity (selectivity of commercial Pd/C: 45%; PdCu-Pd-Cu@C nanocatalyst: 76%). The alkali metal dopants increase the selectivity of the final product on the PdCu-Pd-Cu@C surface because they are electron-rich, which assists in the adsorption of the substrate (selectivity of PdCu-Pd-Cu@C nanocatalyst: 76%; K-doped PdCu-Pd-Cu@C nanocatalysts: 90%). Furthermore, even after being reused 5 times in this research, the final catalytic performance was comparable to that of the initial catalyst.
Synthesis and Characterization of Silver Nanoparticles Prepared with Carrasquilla Fruit Extract (Berberis hallii) and Evaluation of Its Photocatalytic Activity
Authors: Arroyo Geovanna , Angulo Yolanda , Debut Alexis , Cumbal Luis Heriberto
Published: September 2021

In this study, silver nanoparticles (AgNPs) were obtained using a green-chemistry procedure. For this protocol, the Carrasquilla extract (CE) (Berberis hallii) and a AgNO3 solution were used as the reducing agent and the metal precursor, respectively. The as-prepared AgNPs after characterization were then used to evaluate the degradation of the methylene blue (MB), the safranin (SF), and the mixture of both dyes in the aqueous phase under solar light irradiation. The photocatalytic activity of AgNPs for the degradation of the MB (k = 0.0092 min−1) was higher than the SF (k = 0.00016 min−1) due to the susceptibility of the thiazine ring of the MB to photodegradation contrasted to the phenyl phenazine of the SF. However, SF was mostly removed by adsorption with a maximum uptake of 2907 mg/g. Overall, this eco-friendly and green conversion of silver ions to metallic elements avoids the use of toxic chemicals and could be applied for the degradation/adsorption of dyes used in several industrial processes.
Mo-Doped CuO Nanomaterial for Photocatalytic Degradation of Water Pollutants under Visible Light
Authors: Maraj Mudassar , Raza Ahmad , Wang Xinjie , Chen Jie , Riaz Khalid Nadeem , Sun Wenhong
Published: September 2021

Recently, metal oxide-based nano-photocatalysts have gained much attention in waste water remediation due to their outstanding properties. In this report, a novel Mo-doped CuO nanomaterial was successfully prepared and utilized for the degradation of methylene blue water pollutant. The molybdenum content was varied from 1–5 wt.% to obtain the desired modified CuO based nanomaterials. The crystalline structures of as prepared materials were investigated by XRD diffraction technique, which explored the successful fabrication of monoclinic structure based CuO nanomaterials. For morphological study, SEM and HRTEM techniques were probed, which had also proved the successful preparation of nanoparticles-based material. SAED is used to check the crystallinity of the sample. The EDX and XPS analysis were performed to evaluate the elemental composition of Mo-doped CuO nanomaterials. The optical characteristics were explored via UV-vis and PL techniques. These studies have showed that the energy bandgap of CuO was decreased from 1.55 eV to 1.25 eV due to Mo doping. The photocatalytic efficiency of Mo-doped CuO nanomaterials was evaluated by degrading methylene blue (MB) under visible light-irradiation. Among different Mo-doped CuO based nanomaterials, the 4 wt.% Mo-doped CuO sample have shown highest degradation activity against MB dye. These results verified that the optimized material can be used for photocatalytic applications, especially for the purification of waste water.
Atrial Cardiomyopathy: Pathophysiology and Clinical Consequences
Authors: Goette Andreas , Lendeckel Uwe
Published: September 2021

Around the world there are 33.5 million patients suffering from atrial fibrillation (AF) with an annual increase of 5 million cases. Most AF patients have an established form of an atrial cardiomyopathy. The concept of atrial cardiomyopathy was introduced in 2016. Thus, therapy of underlying diseases and atrial tissue changes appear as a cornerstone of AF therapy. Furthermore, therapy or prevention of atrial endocardial changes has the potential to reduce atrial thrombogenesis and thereby cerebral stroke. The present manuscript will summarize the underlying pathophysiology and remodeling processes observed in the development of an atrial cardiomyopathy, thrombogenesis, and atrial fibrillation. In particular, the impact of oxidative stress, inflammation, diabetes, and obesity will be addressed.
A Review on Graphene Based Materials and Their Antimicrobial Properties
Authors: Yaragalla Srinivasarao , Bhavitha Karanath Balendran , Athanassiou Athanassia
Published: September 2021

Graphene-based materials are found as excellent resources and employed as efficient anti-microbial agents, and they have been receiving significant attention from scientists and researchers in this regard. By giving special attention to recent applications of graphene-based materials, the current review is dedicated to unveiling the antimicrobial properties of graphene and its hybrid composites and their preparation methods. Different factors like the number of layers, concentration, size, and shape of the antibacterial activity are thoroughly discussed. Graphene-based materials could damage the bacteria physically by directly contacting the cell membrane or wrapping the bacterial cell. It can also chemically react to bacteria through oxidative stress and charge transfer mechanisms. This review explains such mechanisms thoroughly and summarizes the antibacterial applications (wound bandages, coatings, food packaging, etc.) of graphene and its hybrid materials.
Investigations on the Adhesive Contact Behaviors between a Viscoelastic Stamp and a Transferred Element in Microtransfer Printing
Authors: Jiang Ling , Wu Mengjie , Yu Qiuping , Shan Yuxia , Zhang Yuyan
Published: September 2021

Microtransfer printing is a sophisticated technique for the heterogeneous integration of separately fabricated micro/nano-elements into functional systems by virtue of an elastomeric stamp. One important factor influencing the capability of this technique depends on the adhesion between the viscoelastic stamp and the transferred element. To provide theoretical guidance for the control of adhesion in the transfer printing process, a finite element model for the viscoelastic adhesive contact between a polydimethylsiloxane (PDMS) stamp and a spherical transferred element was established, in which the adhesive interaction was modeled by the Lennard-Jones surface force law. Effects of the unloading velocity, preload, and thermodynamic work of adhesion on the adhesion strength, characterized by the pull-off force, were examined for a loading-dwelling-unloading history. Simulation results showed that the unloading path deviated from the loading path due to the viscoelastic property of the PDMS stamp. The pull-off force increased with the unloading velocity, and the increasing ratio was large at first and then became low. Furthermore, the influence of the preload on increasing the pull-off force was more significant under larger unloading velocity than that under smaller unloading velocity. In addition, the pull-off force increased remarkably with the thermodynamic work of adhesion at a fixed maximum approach.
A Comparative Study of Fabricating IrOx Electrodes by High Temperature Carbonate Oxidation and Cyclic Thermal Oxidation and Quenching Process
Authors: Huang Feifei , Wang Qingrui , Wang Weipeng , Wu Jiangshun , Wang Shuqiang , Zou Yang , Bi Peng , Wen Lei , Jin Ying
Published: September 2021

IrOx electrodes were fabricated by cyclic thermal heating and water quenching (CHQ) process and high temperature carbonate oxidation (HCO), respectively. By examining the E-pH relationship, response rate, potential drift behavior of the fabricated electrodes, the electrodes prepared by CHQ process seemed to show better comprehensive performance. Characterization tests such as scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and electrochemical impedance spectroscopy (EIS) were used to characterize the fabricated IrOx electrodes and find out the reason for the better performance of the electrodes prepared by CHQ process. Morphology tests indicate that the CHQ electrode shows a multi-layer structure with more ion channels, which could provide larger surface area for the H+ response process. Furthermore, combining the XPS, Raman and EIS tests etc., more effective response composition, better crystal quality, and smaller response reaction resistance of surface IrOx film could account for the better performance of the CHQ-fabricated IrOx electrode. The film formation process, H+ response mechanism, as well as the response behavior difference between the two kinds of the electrodes are further elaborated.
Symmetric Excitons in an (001)-Based InAs/GaAs Quantum Dot Near Si Dopant for Photon-Pair Entanglement
Authors: Shang Xiangjun , Li Shulun , Liu Hanqing , Ma Ben , Su Xiangbin , Chen Yao , Shen Jiaxin , Hao Huiming , Liu Bing , Dou Xiuming , Ji Yang , Sun Baoquan , Ni Haiqiao , Niu Zhichuan
Published: September 2021

The sacrificed-QD-layer method can well control the indium deposition amount to grow InAs quantum dots (QDs) with isotropic geometry. Individual Si dopant above an (001)-based InAs QD proves a new method to build a local electric field to reduce fine structure splitting (FSS = X1−X2) and show D3h symmetric excitons. The lowest FSS obtained is 3.9 μeV with the lowest energy X state (LX) anticlockwise rotate from [1–10] (i.e., zero FSS will be crossed in a proper field). The lateral field projection induces a large eh separation and various FSS, LX, and emission intensity polarization. The lateral field along [1–10] breaks the X1–X2 wavefunction degeneracy for independent HH and VV cascade emissions with robust polarization correlation. With FSS ~4 μeV and T1 ~0.3 ns fastened in a distributed Bragg reflector cavity, polarization-resolved XX–X cross-correlations show fidelity ~0.55 to a maximal entangled state |HH> + |VV>. A higher fidelity and zero FSS will be obtained in the hybrid QD structure with a junction field integrated to tune the FSS and a sub-bandgap excitation to avoid influences from electrons in the barrier.
Rapid Detection of VanA/B-Producing Vancomycin-Resistant Enterococci Using Lateral Flow Immunoassay
Authors: Oueslati Saoussen , Gonzalez Camille , Volland Hervé , Cattoir Vincent , Bernabeu Sandrine , Girlich Delphine , Dulac Duncan , Plaisance Marc , Boutigny Laure , Dortet Laurent , Simon Stéphanie , Naas Thierry
Published: September 2021

Vancomycin-resistant enterococci (VREs) have become one of the most important nosocomial pathogens worldwide, associated with increased treatment costs, prolonged hospital stays and high mortality. Rapid detection is crucial to reduce their spread and prevent infections and outbreaks. The lateral flow immunoassay NG-Test VanB (NG Biotech) was evaluated for the rapid detection of VanB-producing vancomycin-resistant enterococci (VanB-VREs) using 104 well-characterized enterococcal isolates. The sensitivity and specificity were both 100% when bacterial cells were grown in the presence of vancomycin used as a VanB inducer. The NG-Test VanB is an efficient, rapid and easy to implement assay in clinical microbiology laboratories for the confirmation of VanB-VREs from colonies. Together with the NG-Test VanA, they could replace the already existing tests available for the confirmation of acquired vancomycin resistance in enterococci, especially from selective media or from antibiograms, with 100% sensitivity and specificity. Rapid detection in less than 15 min will result in more efficient management of carriers and infected patients. In addition, these tests may be used for positive blood cultures, given a 3.5 h sub-culturing step on Chocolate agar PolyViteX in the presence of a 5-µg vancomycin disk, which is routinely performed in many clinical microbiology laboratories for every positive blood culture for subsequent MALDI-TOF identification of the growing bacteria.
Two-Stage Liver and Tumor Segmentation Algorithm Based on Convolutional Neural Network
Authors: Meng Lu , Zhang Qianqian , Bu Sihang
Published: September 2021

The liver is an essential metabolic organ of the human body, and malignant liver tumors seriously affect and threaten human life. The segmentation algorithm for liver and liver tumors is one of the essential branches of computer-aided diagnosis. This paper proposed a two-stage liver and tumor segmentation algorithm based on the convolutional neural network (CNN). In the present study, we used two stages to segment the liver and tumors: liver localization and tumor segmentation. In the liver localization stage, the network segments the liver region, adopts the encoding–decoding structure and long-distance feature fusion operation, and utilizes the shallow features’ spatial information to improve liver identification. In the tumor segmentation stage, based on the liver segmentation results of the first two steps, a CNN model was designed to accurately identify the liver tumors by using the 2D image features and 3D spatial features of the CT image slices. At the same time, we use the attention mechanism to improve the segmentation performance of small liver tumors. The proposed algorithm was tested on the public data set Liver Tumor Segmentation Challenge (LiTS). The Dice coefficient of liver segmentation was 0.967, and the Dice coefficient of tumor segmentation was 0.725. The proposed algorithm can accurately segment the liver and liver tumors in CT images. Compared with other state-of-the-art algorithms, the segmentation results of the proposed algorithm rank the highest in the Dice coefficient.
Resource Partitioning of Scots Pine (Pinus sylvestris L.) by Pine Shoot Beetles in Stands under Stress Conditions
Authors: Borkowski Andrzej
Published: September 2021

The pine shoot beetles Tomicus piniperda L. and T. minor Hartwig are sympatric species that occur on Scots pine in two habitats. Feeding by the beetles in tree crowns causes significant losses in tree growth and disturbs the crown’s proper development. A review of the subject literature showed that there had been no previous studies of interspecific competition in stands with different degrees of crown damage. The aim of this work was to assess the resource partitioning of stems by the two species in stands with damaged and undamaged crowns. Data were collected in the years 1992–2008 in stands containing Scots pine located at different distances from timber yards. A total of 259 natural traps were laid, and measurements of height and diameter at breast height were made for 900 pines. The surface area of each stem was divided into 20 equal sections by making a division lengthwise (into units) and laterally (into an upper and lower part). In total, 90,501 egg galleries of pine shoot beetles were counted on 9560 stem sections. Feeding by pine shoot beetles in the crowns of pines reduces site productivity and the nutritional suitability of stems. The results of niche segregation indicate pine shoot beetles exhibited spatial specialization in the use of resources. prefers the thicker part of the stem, and T. minor the thinner part. The population of T. piniperda on the trap logs was described using a multiple linear regression model with three explanatory variables. As a result of regression modelling, from the set of variables representing characteristics of habitats, trees and trap logs and the parameters of infestation, the following explanatory variables were selected: range of colonisation of a trap log (rc), site quality class (sqc), and crown undamaged (cu). The explanatory variables included in the MLRM model explain to a significant degree (p < 0.05) the niche breadth of T. piniperda on trap logs. In all validated plots, the mean real and model values for the niche of T. piniperda on the trap logs are similar (p > 0.5), confirming the high accuracy of the developed model.
Crop Planning in Synchronized Crop-Demand Scenarios: A Biobjective Optimization Formulation
Authors: Adenso-Díaz Belarmino , Villa Gabriel
Published: September 2021

Crop planning problems have been extensively studied from different perspectives (profit maximization, optimizing available water use, sustainability, etc.). In this paper, a new approach is proposed that considers new forms of customer-producer relationship, involving long-term cooperation agreements where the product volumes are agreed, and the demand is guaranteed in advance. In this context, typical of manufacturing production systems, crop planning must guarantee a given production level on specific dates, thus becoming deterministic in nature. In that context, this paper introduces a lexicographic biobjective optimization approach that, in addition to cost minimization, aims at minimizing the risk of not meeting the agreed demands. The latter is done by maximizing the geographic dispersion of the crops so that weather risk is mitigated. A number of experiments have been carried out to test the proposed approach, showing the high complexity of the solution and opening the door to new solution procedures for a problem that results from interest given to the new type of relationships in the food logistics chain.
A Scoping Review on Minimum Foot Clearance: An Exploration of Level-Ground Clearance in Individuals with Abnormal Gait
Authors: Al Bochi Abdulrahman , Delfi Ghazaleh , Dutta Tilak
Published: September 2021

Background: Falls are a major health concern, with one in three adults over the age of 65 falling each year. A key gait parameter that is indicative of tripping is minimum foot clearance (MFC), which occurs during the mid-swing phase of gait. This is the second of a two-part scoping review on MFC literature. The aim of this paper is to identify vulnerable populations and conditions that impact MFC mean or median relative to controls. This information will inform future design/maintenance standards and outdoor built environment guidelines. Methods: Four electronic databases were searched to identify journal articles and conference papers that report level-ground MFC characteristics. Two independent reviewers screened papers for inclusion. Results: Out of 1571 papers, 43 relevant papers were included in this review. Twenty-eight conditions have been studied for effects on MFC. Eleven of the 28 conditions led to a decrease in mean or median MFC including dual-task walking in older adults, fallers with multiple sclerosis, and treadmill walking. All studies were conducted indoors. Conclusions: The lack of standardized research methods and covariates such as gait speed made it difficult to compare MFC values between studies for the purpose of defining design and maintenance standards for the outdoor built environment. Standardized methods for defining MFC and an emphasis on outdoor trials are needed in future studies.
Effects of Different Finger Grips and Arm Positions on the Performance of Manipulating the Chinese Brush in Chinese Adolescents
Authors: Lee Ching-Hung , Lee Yu-Chi
Published: September 2021

This study aimed to investigate the effects of finger grip and wrist position on Chinese calligraphy handwriting (CCH). Thirty participants were recruited in the study and asked to manipulate the Chinese brush using two finger grip methods (three-finger grip and five-finger grip) and two wrist positions (suspended wrist and raised wrist). Three experimental writing tasks were applied to investigate writing stability, agility, and hand–eye coordination, and to evaluate the completion time (s), area of error (cm2), and error times. Subjective responses (arm aching level, ease of grip, exertion level, and comfort) regarding the four combinations of Chinese brush manipulation were measured. The results indicated significantly better performance with the three-finger grip for the stability and agility tests, and with the five-finger grip for the hand–eye coordination task. Using the suspended wrist position for CCH allowed better agility and hand–eye coordination than the raised wrist position. In consideration of the results of the four operational combinations, the three-finger grip with a suspended wrist position demonstrated the best performance in both objective and subjective measurements. It is recommended for application in the early learning stage. These findings can be considered when teaching Chinese brushes for beginners of CCH in schools.
Correction: Shrader-Frechette, K.; Biondo, A.M. Data-Quality Assessment Signals Toxic-Site Safety Threats and Environmental Injustices. Int. J. Environ. Res. Public Health 2021, 18, 2012
Authors: Shrader-Frechette Kristin , Biondo Andrew M.
Published: September 2021

The authors would like to make the following corrections (1 and 2) to this paper [...]
Impact of Best-Fitted Control Selection on Effect Size: An Example in Functional GI Disorder Case–Control Studies
Authors: Adibi Peyman , Agah Shahram , Doosti Hassan , Feizi Awat
Published: September 2021

Background: Effect sizes are the most useful quantities for communicating the practical significance of results and helping to facilitate cumulative science. We hypothesize that the selection of the best-fitted controls can significantly affect the estimated effect sizes in case–control studies. Therefore, we decided to exemplify and clarify this effect on effect size using a large data set. The objective of this study was to investigate the association among variables in functional gastrointestinal disorders (FGIDs) and mental health problems, common ailments that reduce the quality of life of a large proportion of the community worldwide. Method: In this methodological study, we constitute case and control groups in our study framework using the Epidemiology of Psychological, Alimentary Health and Nutrition (SEPAHAN) dataset of 4763 participants. We devised four definitions for control in this extensive database of FGID patients and analyzed the effect of these definitions on the odds ratio (OR): 1. conventional control: without target disorder/syndrome (sample size 4040); 2. without any positive criteria: criterion-free control (sample size 1053); 3. syndrome-free control: without any disorder/syndrome (sample size 847); 4. symptom-free control: without any symptoms (sample size 204). We considered a fixed case group that included 723 patients with a Rome III-based definition of functional dyspepsia. Psychological distress, anxiety, and depression were considered as dependent variables in the analysis. Logistic regression was used for association analysis, and the odds ratio and 95% confidence interval (95%CI) for OR were reported as the effect size. Results: The estimated ORs indicate that the strength of the association in the first case–control group is the lowest, and the fourth case–control group, including controls with completely asymptomatic people, is the highest. Ascending effect sizes were obtained in the conventional, criterion-free, syndrome-free, and symptom-free control groups. These results are consistent for all three psychological disorders, psychological distress, anxiety, and depression. Conclusions: This study shows that a precise definition of the control is mandatory in every case–control study and affects the estimated effect size. In clinical settings, the selection of symptomatic controls using the conventional definition could significantly diminish the effect size.
Prediction of Geosmin at Different Depths of Lake Using Machine Learning Techniques
Authors: Kwon Yong-Su , Cho In-Hwan , Kim Ha-Kyung , Byun Jeong-Hwan , Bae Mi-Jung , Kim Baik-Ho
Published: September 2021

Geosmin is a major concern in the management of water sources worldwide. Thus, we predicted concentration categories of geosmin at three different depths of lakes (i.e., surface, middle, and bottom), and analyzed relationships between geosmin concentration and factors such as phytoplankton abundance and environmental variables. Data were collected monthly from three major lakes (Uiam, Cheongpyeong, and Paldang lakes) in Korea from May 2014 to December 2015. Before predicting geosmin concentration, we categorized it into four groups based on the boxplot method, and multivariate adaptive regression splines, classification and regression trees, and random forest (RF) were applied to identify the most appropriate modelling to predict geosmin concentration. Overall, using environmental variables was more accurate than using phytoplankton abundance to predict the four categories of geosmin concentration based on AUC and accuracy in all three models as well as each layer. The RF model had the highest predictive power among the three SDMs. When predicting geosmin in the three water layers, the relative importance of environmental variables and phytoplankton abundance in the sensitivity analysis was different for each layer. Water temperature and abundance of Cyanophyceae were the most important factors for predicting geosmin concentration categories in the surface layer, whereas total abundance of phytoplankton exhibited relatively higher importance in the bottom layer.
Socioeconomic Status and Prosocial Behavior: The Mediating Roles of Community Identity and Perceived Control
Authors: Wang Yanli , Yang Chao , Zhang Yanchi , Hu Xiaoyong
Published: September 2021

Background: Previous studies have examined the association between socioeconomic status and prosocial behavior, but the underlying mechanism between them is unclear. The present study aimed to examine the serially mediating roles of community identity and perceived control in this relationship. Methods: Using the convenient sampling technique, a total of 477 Chinese adults from Chinese communities, and ranging in age from 20 to 65 completed the questionnaires for objective socioeconomic status, the MacArthur scale of subjective socioeconomic status, an eight-item community identity scale, the perceived control scale, and a prosocial tendencies measure. Bivariate correlation analysis and regression analysis were used to examine the relationships among the major variables. Results: Socioeconomic status was positively associated with prosocial behavior. It was also found that community identity and perceived control played mediating roles between socioeconomic status and prosocial behavior, respectively. In addition, community identity and perceived control also had a serially mediating role in the relationship. Conclusions: Community identity and perceived control played a serially mediating role in the association between socioeconomic status and prosocial behavior. The findings in the present study contribute to understanding the underlying mechanism in the association between socioeconomic status and prosocial behavior among adults, and have important implications for interventions aimed at improving prosocial behavior in lower-status individuals.
Life Course Neighbourhood Deprivation and Self-Rated Health: Does It Matter Where You Lived in Adolescence and Do Neighbourhood Effects Build Up over Life?
Authors: Jivraj Stephen , Nicholas Owen , Murray Emily T. , Norman Paul
Published: September 2021

There is an overreliance on concurrent neighbourhood deprivation as a determinant of health. Only a small section of the literature focuses on the cumulative exposure of neighbourhood deprivation over the life course. This paper uses data from the 1958 National Child Development Study, a British birth cohort study, linked to 1971–2011 Census data at the neighbourhood level to longitudinally model self-rated health between ages 23 and 55 by Townsend deprivation score between ages 16 and 55. Change in self-rated health is analysed using ordinal multilevel models to test the strength of association with neighbourhood deprivation at age 16, concurrently and cumulatively. The results show that greater neighbourhood deprivation at age 16 predicts worsening self-rated health between ages 33 and 50. The association with concurrent neighbourhood deprivation is shown to be stronger compared with the measurement at age 16 when both are adjusted in the model. The concurrent association with change in self-rated health is explained by cumulative neighbourhood deprivation. These findings suggest that neglecting exposure to neighbourhood deprivation over the life course will underestimate the neighbourhood effect. They also have potential implications for public policy suggesting that neighbourhood socioeconomic equality may bring about better population health.