bluuebunny/crossref_metadata_2025 huggingface dataset:
DIAGNOSTIC SIGNS OF MYOCARDIAL REPERFUSION INJURY AFTER CORONARY ARTERY BYPASS GRAFTING
Authors:   Republican Scientific and Practical Centre «Cardiology», Shybekа N. , Gelis L. ,   Republican Scientific and Practical Centre «Cardiology», Rusak T. ,   Republican Scientific and Practical Centre «Cardiology»
Published: September 2021

One of the main causes for operative mortality and perioperative complications after coronary artery bypass grafting is myocardial reperfusion injury following the restoration of the coronary circulation in the ischemic zone of the myocardium and characterized by myocardial, electrophysiological and vascular dysfunction. In order to identify the diagnostic signs of myocardial reperfusion injury after coronary artery bypass grafting, a prospective study was conducted, which included 89 patients with ischemic heart disease and forthcoming coronary artery bypass grafting either on-pump or off-pump. Postischemic myocardial dysfunction was assessed using transesophageal echocardiography, morphological and functional signs of myocardial reperfusion injury were detected using cardiac magnetic resonance imaging, moreover, the level of highly sensitive troponin, myoglobin, creatine phosphokinase-MB, metalloproteinase-2, and highly sensitive C-reactive protein was measured to assess the contribution of biomarkers to the development of reperfusion injuries. The obtained data allowed us to assess the morphological and functional characteristics of postischemic myocardial dysfunction and identify diagnostic signs of irreversible reperfusion injuries.
JUSTIFICATION OF TECHNOLOGIES FOR ORGANIZING MEDICAL CARE FOR PATIENTS WITH HIGH CARDIOVASCULAR RISK ON THE EXAMPLE OF THE BREST REGION (PART 1)
Authors:   Brest Regional Cardiology Dispensary, Pabivantsava N.
Published: September 2021

In order to substantiate organizational measures for early detection and tertiary prevention of cardiovascular diseases, the causal relationships of high morbidity, disability, and mortality due to cardiovascular diseases, coronary heart disease and its complications were studied in the population of the Brest region in the period from 2006 to 2010. Measures to improve the organization of preventive medical examination of patients from cardiovascular risk groups with prognostically unfavorable outcomes were suggested. Through the implementation of an organizational experiment in 2012-2017, it was possible to achieve a positive medical and social effect, expressed in increasing the availability of multi-level and high-tech care to patients in need, as well as in improving the medical and demographic indicators of the Brest region in general and in the diseases of the circulatory system in particular, which formed the basis of the second part of this article.
Limitations of the Radon Tracer Method (RTM) to estimate regional Greenhouse Gases (GHG) emissions – a case study for methane in Heidelberg
Authors: Levin Ingeborg , Karstens Ute , Hammer Samuel , DellaColetta Julian , Maier Fabian , Gachkivskyi Maksym
Published: September 2021

Abstract. Correlations of night-time atmospheric methane (CH4) and 222Radon (222Rn) observations in Heidelberg, Germany, were evaluated with the Radon Tracer Method (RTM) to estimate the trend of annual CH4 emissions from 1996–2020 in the catchment area of the station. After an initial 30 % decrease of emissions from 1996 to 2004, no further systematic trend but small inter-annual variations were observed thereafter. This is in accordance with the trend of emissions until 2010 reported by the EDGARv6.0 inventory for the surroundings of Heidelberg. We show that the reliability of total CH4 emission estimates with the RTM critically depends on the accuracy and representativeness of the 222Rn exhalation rate from soils in the catchment area of the site. Simply using 222Rn fluxes as estimated by Karstens et al. (2015) could lead to biases in the estimated greenhouse gases (GHG) fluxes as large as a factor of two. RTM-based GHG flux estimates also depend on the parameters chosen for the night-time correlations of CH4 and 222Rn, such as the night-time period for regressions as well as the R2 cut-off value for the goodness of the fit. Quantitative comparison of total RTM-based top-down with bottom-up emission inventories requires representative high-resolution footprint modelling, particularly in polluted areas where CH4 emissions show large heterogeneity. Even then, RTM-based estimates are likely biased low if point sources play a significant role in the station/observation footprint as their emissions are not captured by the RTM method. Long-term representative 222Rn flux observations in the catchment area of a station are indispensable in order to apply the RTM method for reliable quantitative flux estimations of GHG emissions from atmospheric observations.
Odds and ends of atmospheric mercury in Europe and over northern Atlantic Ocean: Temporal trends of 25 years of measurements
Authors: Custódio Danilo , Slemr Franz , Pfaffhuber Katrine Aspmo , Spain T. Gerard , Pankratov Fidel F. , Strigunova Iana , Molepo Koketso , Skov Henrik , Bieser Johannes , Ebinghaus Ralf
Published: September 2021

Abstract. The Global Monitoring Plan of the Minamata Convention on Mercury was established to generate long-term data necessary for evaluating the effectiveness of regulatory measures at a global scale. After 25 years monitoring (since 1995), Mace Head is one of the atmospheric monitoring stations with the longest mercury record, and has produced sufficient data for the analysis of temporal trends of Total Gaseous Mercury (TGM) in Europe and the Northern Atlantic. Using concentration-weighted trajectories for atmospheric mercury measured at Mace Head as well as other five locations in Europe, Amderma, Andøya, Villum, Waldhof and Zeppelin we identify the regional probabilistic source contribution factor and its changes for the period of 1996 to 2019. Temporal trends indicate that concentrations of mercury in the atmosphere in Europe and the Northern Atlantic have declined significantly over the past 25 years, at a non-monotonic rate averaging of 0.03 ng m-3 year-1. Concentrations of TGM at remote marine sites were shown to be affected by continental long-range transport, and evaluation of reanalysis back-trajectories display a significant decrease of TGM in continental air masses from Europe in the last two decades. In addition, using the relationship between mercury and other atmospheric trace gases that could serve as a source signature, we perform factorization regression analysis, based on positive rotatable factorization of non-singular matrix to solve probabilistic mass function. We reconstructed atmospheric mercury concentration and accessed the contribution of the major natural and anthropogenic sources. The positive matrix factorization (PMF) reveals that the downward trend is mainly associated with a factor with a high load of long-lived anthropogenic species.
Large Herbivores Affecting Permafrost – Impacts of Grazing on Permafrost Soil Carbon Storage in Northeastern Siberia
Authors: Windirsch Torben , Grosse Guido , Ulrich Mathias , Forbes Bruce C. , Göckede Mathias , Wolter Juliane , Macias-Fauria Marc , Olofsson Johan , Zimov Nikita , Strauss Jens
Published: September 2021

Abstract. The risk of carbon emissions from permafrost ground is linked to ground temperature and thus in particular to thermal insulation by vegetation and organic soil layers in summer and snow cover in winter. This ground insulation is strongly influenced by the presence of large herbivorous animals browsing for food. In this study, we examine the potential impact of large herbivore presence on the ground carbon storage in thermokarst landscapes of northeastern Siberia. Our aim is to understand how intensive animal grazing may affect permafrost thaw and hence organic matter decomposition, leading to different ground carbon storage, which is significant in the active layer. Therefore, we analysed sites with differing large herbivore grazing intensity in the Pleistocene Park near Chersky and measured maximum thaw depth, total organic carbon content and decomposition state by δ13C isotope analysis. In addition, we determined sediment grain size composition as well as ice and water content. We found the thaw depth to be shallower and carbon storage to be higher in intensively grazed areas compared to extensively and non-grazed sites in the same thermokarst basin. The intensive grazing presumably leads to a more stable thermal ground regime and thus to increased carbon storage in the thermokarst deposits and active layer. However, the high carbon content found within the upper 20 cm on intensively grazed sites could also indicate higher carbon input rather than reduced decomposition, which requires further studies. We connect our findings to more animal trampling in winter, which causes snow disturbance and cooler winter ground temperatures during the average annual 225 days below freezing. This winter cooling overcompensates ground warming due to the lower insulation associated with shorter heavily grazed vegetation during the average annual 140 thaw days. We conclude that intensive grazing influences the carbon storage capacities of permafrost areas and hence might be an actively manageable instrument to reduce net carbon emission from these sites.
Total column ozone measurements by the Dobson spectrophotometer at Belsk (Poland) for the period 1963–2019: homogenization and adjustment to the Brewer spectrophotometer
Authors: Krzyścin Janusz W. , Rajewska-Więch Bonawentura , Jarosławski Janusz
Published: September 2021

Abstract. The total column ozone (TCO3) measurements by the Dobson
spectrophotometer (serial no. 84) have been carried out at Belsk station
(51∘50′ N, 20∘47′ E), Poland, since 23 March 1963. In total, ∼115 000 intraday manual observations were made by 31 December 2019. These observations were performed for different combinations of double wavelength pairs in the ultraviolet range and observation types, i.e., direct sun (DS), zenith blue (ZB), and zenith cloudy (ZC) depending on weather conditions. The long-term stability of the instrument was supported by frequent (almost every 4 years) intercomparisons with the world standard spectrophotometer.
Trend analyses, based on the monthly and yearly averaged TCO3, can be
carried out without any additional corrections to the intraday values. To
adjust these data to the Brewer spectrophotometer observations, which were
also performed at Belsk, a procedure is proposed to account for less
accurate Dobson observations under low solar elevation, presence of clouds,
and the temperature dependence of ozone absorption. The adjusted time series
shows that the Brewer–Dobson monthly averaged differences are in the range of about ±0.5 %. The intraday TCO3 database, divided into
three periods (1963–1979, 1980–1999, and 2000–2019), is freely available
at https://doi.org/10.1594/PANGAEA.919378 (Rajewska-Więch et al., 2020).
Datasets for research on groundwater flow and its interactions with surface water in an alpine catchment on the northeastern Tibetan Plateau, China
Authors: Pan Zhao , Ma Rui , Sun Ziyong , Hu Yalu , Chang Qixin , Ge Mengyan , Wang Shuo , Bu Jianwei , Long Xiang , Pan Yanxi , Zhao Lusong
Published: September 2021

Abstract. Climate warming has significantly changed the hydrological cycle in cold regions, especially in areas with distributed permafrost. Groundwater flow and its interactions with surface water are important components of the hydrological process; however, few studies or modeling works have been based on long-term groundwater level, temperature, hydrogeochemistry or isotopic field observations from boreholes due to obstacles such as remote locations, limited infrastructure, and harsh work conditions. In the Hulugou catchment located in the headwater region of the Heihe River on the northeastern Tibetan Plateau (TP), we drilled four sets of depth-specific wells and monitored the dynamic groundwater levels and temperatures at different depths. Surface water (including river water, glacier meltwater, and snow meltwater), precipitation, groundwater from boreholes, spring water, and soil water samples were collected to measure the hydrochemistry, dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), and stable and radioactive isotopes at 64 sites. This study provides datasets of these groundwater parameters spanning six consecutive years of monitoring/measurements. These data can be used to investigate the groundwater flow process and the interactions between groundwater and surface water on the TP under global climate change. The datasets provided in this paper can be obtained at https://doi.org/10.5281/zenodo.5184470 (Ma et al., 2021b) and will be subject to further updates.
Position correction in dust storm forecasting using LOTOS-EUROS v2.1: grid-distorted data assimilation v1.0
Authors: Jin Jianbing , Segers Arjo , Lin Hai Xiang , Henzing Bas , Wang Xiaohui , Heemink Arnold , Liao Hong
Published: September 2021

Abstract. When calibrating simulations of dust clouds, both the intensity and
the position are important.
Intensity errors arise mainly from uncertain emission and sedimentation strengths,
while position errors are attributed either to imperfect emission timing or to uncertainties in the transport.
Though many studies have been conducted on the calibration or correction of dust simulations,
most of these focus on intensity solely and leave the position errors mainly unchanged.
In this paper, a grid-distorted data assimilation,
which consists of an image-morphing method and an ensemble-based variational assimilation,
is designed for realigning a simulated dust plume to correct the position error.
This newly developed grid-distorted data assimilation
has been applied to a dust storm event in May 2017 over East Asia.
Results have been compared for three configurations:
a traditional assimilation configuration
that focuses solely on intensity correction,
a grid-distorted data assimilation that focuses on position correction only and the
hybrid assimilation that combines these two.
For the evaluated case, the position misfit in the simulations is shown to be dominant in the results.
The traditional emission inversion only slightly improves the dust simulation, while the grid-distorted
data assimilation effectively improves the dust simulation and forecasting.
The hybrid assimilation that corrects both position and intensity of the dust load provides
the best initial condition for forecasting of dust concentrations.
A Framework for Irrigation Performance Assessment Using WaPOR data: The case of a Sugarcane Estate in Mozambique
Authors: Chukalla Abebe Demissie , Mul Marloes L. , van der Zaag Pieter , van Halsema Gerardo , Mubaya Evaristo , Muchanga Esperança , den Besten Nadja , Karimi Poolad
Published: September 2021

Abstract. The growing competition for the finite land and water resources and the need to feed an ever-growing population requires new techniques to monitor the performance of irrigation schemes and improve land and water productivity. Datasets from FAO’s portal to monitor Water Productivity through Open access Remotely sensed derived data (WaPOR) is increasingly applied as a cost-effective means to support irrigation performance assessment and identifying possible pathways for improvement. This study presents a framework that applies WaPOR data to assess irrigation performance indicators including uniformity, equity, adequacy and land and water productivity differentiated by irrigation method (furrow, sprinkler and centre pivot) at the Xinavane sugarcane estate, Mozambique. The WaPOR data on water, land and climate is near-real-time and spatially distributed, with the finest spatial resolution in the area of 100 m. The WaPOR data were first validated agronomically by examining the biomass response to water, then the data was used to systematically analyse seasonal indicators for the period 2015 to 2018 on ~8,000 ha. The WaPOR based yield estimates were found to be comparable to the estate-measured yields with ±20 % difference, root mean square error of 19 ± 2.5 ton/ha and mean absolute error of 15 ± 1.6 ton/ha. A climate normalization factor that enables the spatial and temporal comparison of performance indicators are applied. The assessment highlights that in Xinavane no single irrigation method performs the best across all performance indicators. Centre pivot compared to sprinkler and furrow irrigation shows higher adequacy, equity, and land productivity, but lower water productivity. The three irrigation methods have excellent uniformity (~94 %) in the four seasons and acceptable adequacy for most periods of the season except in 2016, when a drought was observed. While this study is done for sugarcane in one irrigation scheme, the approach can be broadened to compare other crops across fields or irrigation schemes across Africa with diverse management units in the different agro-climatic zone within FaO WaPOR coverage. We conclude that the framework is useful for assessing irrigation performance using the WaPOR dataset.
Opportunities for seasonal forecasting to support water management outside the tropics
Authors: Jackson-Blake Leah Amber , Clayer François , de Eyto Elvira , French Andrew , Frías María Dolores , Mercado-Bettín Daniel , Moore Tadhg , Puértolas Laura , Poole Russell , Rinke Karsten , Shikhani Muhammed , van der Linden Leon , Marcé Rafael
Published: September 2021

Abstract. Advance warning of seasonal conditions has potential to assist water management in planning and risk mitigation, with large potential social, economic and ecological benefits. In this study, we explore the value of seasonal forecasting for decision making at five case study sites located in extratropical regions. The forecasting tools used integrate seasonal climate model forecasts with freshwater impact models of catchment hydrology, lake conditions (temperature, level, chemistry and ecology) and fish migration timing, and were co-developed together with stakeholders. To explore the decision making value of forecasts, we carried out a qualitative assessment of: (1) how useful forecasts would have been for a problematic past season, and (2) the relevance of any “windows of opportunity” (seasons and variables where forecasts are thought to perform well) for management. Overall, stakeholders were optimistic about the potential for improved decision making and identified actions that could be taken based on forecasts. However, there was often a mismatch between those variables that could best be predicted and those which would be most useful for management. Reductions in forecast uncertainty and a need to develop practical hands-on experience were identified as key requirements before forecasts would be used in operational decision making. Seasonal climate forecasts provided little added value to freshwater forecasts in the study sites, and we discuss the conditions under which seasonal climate forecasts with only limited skill are most likely to be worth incorporating into freshwater forecasting workflows.
Salinity as a key control on the diazotrophic community composition in the Baltic Sea
Authors: Reeder Christian Furbo , Stoltenberg Ina , Javidpour Jamileh , Löscher Carolin Regina
Published: September 2021

Abstract. Over the next decade, the Baltic Sea is predicted to undergo severe changes including a decrease in salinity due to altering precipitation. This will likely impact the distribution and community composition of Baltic Sea N2 fixing microbes, of which especially heterocystous cyanobacteria are adapted to low salinities and may expand to waters with currently higher salinity, including the Danish Strait and Kattegat, while other high-salinity adapted N2 fixers might decrease in abundance. In order to explore the impact of salinity on the distribution and activity of different diazotrophic clades, we followed the natural salinity gradient from the Eastern Gotland and Bornholm Basins through the Arkona Basin to the Kiel Bight and combined N2 fixation rate measurements with a molecular analysis of the diazotrophic community using the key functional marker gene for N2 fixation nifH, as well as the key functional marker genes anf and vnf, encoding for the two alternative nitrogenases. We detected N2 fixation rates between 0.7 and 6 nmol N L-1 d-1, and the diazotrophic community was dominated by the cyanobacterium Nodularia and the small unicellular, cosmopolitan cyanobacterium UCYN-A. Nodularia was present in abundances between 8.07 x 105 and 1.6 x 107 copies L-1 in waters with salinities of 10 and below, while UCYN-A reached abundances of up to 4.5 x 107 copies L-1 in waters with salinity above 10. Besides those two cyanobacterial diazotrophs, we found several clades of proteobacterial N2 fixers and alternative nitrogenase genes associated with Rhodopseudomonas palustris, a purple non-sulfur bacterium. Based on statistical testing, salinity was identified as the primary parameter describing the diazotrophic distribution, while pH and temperature did not have a similarly significant influence on the diazotrophic distribution. While this statistical analysis will need to be explored in direct experiments, it gives an indication for a future development of diazotrophy in a freshening Baltic Sea with UCYN-A retracting to more saline North Sea waters and heterocystous cyanobacteria expanding as salinity decreases.
Holocene sea-ice dynamics in Petermann Fjord in relation to ice tongue stability and Nares Strait ice arch formation
Authors: Detlef Henrieka , Reilly Brendan , Jennings Anne , Mørk Jensen Mads , O'Regan Matt , Glasius Marianne , Olsen Jesper , Jakobsson Martin , Pearce Christof
Published: September 2021

Abstract. The Petermann 2015 expedition to Petermann Fjord and adjacent Hall Basin recovered a transect
of cores, extending from Nares Strait to underneath the 48 km long ice
tongue of Petermann glacier, offering a unique opportunity to study
ice–ocean–sea ice interactions at the interface of these realms. First
results suggest that no ice tongue existed in Petermann Fjord for large
parts of the Holocene, raising the question of the role of the ocean and the
marine cryosphere in the collapse and re-establishment of the ice tongue.
Here we use a multi-proxy approach (sea-ice-related biomarkers, total
organic carbon and its carbon isotopic composition, and benthic and
planktonic foraminiferal abundances) to explore Holocene sea ice dynamics at
OD1507-03TC-41GC-03PC in outer Petermann Fjord. Our results are in line with
a tight coupling of the marine and terrestrial cryosphere in this region
and, in connection with other regional sea ice reconstructions, give
insights into the Holocene evolution of ice arches and associated landfast
ice in Nares Strait. The late stages of the regional Holocene Thermal Maximum (6900–5500 cal yr BP) were marked by reduced seasonal sea ice concentrations in Nares
Strait and the lack of ice arch formation. This was followed by a
transitional period towards Neoglacial cooling from 5500–3500 cal yr BP,
where a southern ice arch might have formed, but an early seasonal breakup
and late formation likely caused a prolonged open water season and enhanced
pelagic productivity in Nares Strait. Between 3500 and 1400 cal yr BP, regional records suggest the formation of a stable northern ice arch
only, with a short period from 2500–2100 cal yr BP where a southern ice
arch might have formed intermittently in response to atmospheric cooling
spikes. A stable southern ice arch, or even double arching, is also inferred
for the period after 1400 cal yr BP. Thus, both the inception of a small
Petermann ice tongue at ∼ 2200 cal yr BP and its rapid
expansion at ∼ 600 cal yr BP are preceded by a transition
towards a southern ice arch regime with landfast ice formation in Nares
Strait, suggesting a stabilizing effect of landfast sea ice on Petermann
Glacier.
Retractación: [Il califfato di Cordoba e le suggestioni di Bisanzio. Un caso di “sinfonie protocollari ]
Authors: Di Cosmo Antonio Pio
Published: September 2021

Retractación del artículo: Di Cosmo, A. P. (2008). Il califfato di Cordoba e le suggestioni di Bisanzio. Un caso di “sinfonie protocollari”. De Medio Aevo, 10 (1) .
A kora gyermekkori lelki egészség támogatásának elmélete és gyakorlata I-II. (Danis Ildikó – Németh Tünde – Prónay Beáta – Góczán-Szabó Ildikó – Hédervári-Heller Éva [szerk.])
Authors: Topolánszkyné Zsindely Katalin
Published: September 2021

.
Intraoperative risk assessment of
carcinomatosis development after radical
surgery for gastric cancer
Authors: Reutovich M. Yu. , Krasko O. V.
Published: September 2021

Relevance: Metachronous peritoneal dissemination

(MPD) is the most frequent pattern of gastric cancer (GC)

progression after radical surgery. It is necessary to take into

account the existing risk of MPD development to ensure a

substantiated administration of intraperitoneal chemotherapy for its timely prevention.

The purpose of the study was to raise the MPD prognostication efficacy.

Results: The treatment outcomes of 1,065 radically operated patients (males – 640, 60.1%; females – 425, 39.9%)

aged 23 to 89 years (median age – 63±12) showed that a high

risk of GC recurrence in the form of peritoneal dissemination

is associated with: (1) metastatic invasion of the regional

lymph node – pN2-3 – RR 2.0 (95% CI 1.5–2.7), р < 0.001; (2)

ulcero-infiltrative and diffuse infiltrative forms of primary

gastric cancer growth – RR 3.7 (95% CI 2.5–5.5), р < 0,001),

and RR 2.3 (95% CI 1.5–3.6), р<0,001; (3) serosa invasion by

primary GC (pT4) – RR 2.5 (95% CI 1.8–3.6), р<0,001; (4) combined surgical treatment vs. standard surgery – RR 1.8 (95% CI

1.2–2.7), р=0.005; and (5) performing gastrectomy vs. distal

resection – RR 1.6 (95% CI 1.2–2.2), р=0.004.

A multivariate analysis (Fine-Grey model) was done to

propose a prognostic model for an intraoperative estimate of

the MPD development probability to determine indications

for intraoperative intraperitoneal chemotherapy (concordance index of 0.75).

Conclusion: The proposed nomogram- or formula-based

prognostic model allows a differentiated approach to administering intraoperative intraperitoneal chemotherapy taking

into account the existing probability of peritoneal dissemination development.
Correlation between p53 expression and
hepatocellular carcinoma differentiation grade
Authors: ISSAMATOV B. K. , YENIN E. A. , MEDEUBEKOV U. Sh. , BAYMAKHANOV B. B.
Published: September 2021

Relevance: Hepatocellular carcinoma (HCC) is one of the world’s most common liver cancers and fatal malignant neoplasms. According to GLOBOCAN 2018, liver cancer ranks sixth in incidence (842,000 new cases) and fourth in mortality

(782,000 deaths) globally. In Kazakhstan, there is an increase in HCC incidence from 879 cases in 2016 up to 984 cases in 2017,

which amounted to 5.5 cases per 100 000 population. In 2017, the five-year survival rate was 23.7%.

The mutations in the p53 gene that encodes the p53 protein are most frequent in HCC (35.2%). A high level of nuclear expression of p53 and a decrease in apoptosis of tumor cells with a simultaneous increase in their proliferative activity, noted in

HCC cells, are important for the prognosis of the disease. There is a correlation between poor prognosis, a decreased survival of

patients with HCC, and high expression of the p53 oncoprotein in HCC.

U. Nzeako et al. have revealed a strong correlation of HCC histological differentiation with the patient survival rate. Therefore, a study of the correlation between p53 expression and HCC differentiation grade is very relevant.

The purpose of this study was to analyze the correlation between p53 expression and HCC differentiation grade.

Results: p53 was overexpressed in 18% of HCC cases; the expression was high in 62% and low in 20% of HCC cases. In

well-differentiated HCC (G1), the p53-immunopositive nuclei expression was low in 10 cases and high in 2 cases. In moderately

differentiated HCC (G2), p53 was highly expressed in 21 cases and overexpressed in 2 cases. In poorly-differentiated HCC (G3),

p53 was overexpressed in 7 cases and highly expressed in 8 cases of HCC. The analysis of the correlation between p53 expression and HCC differentiation grade by Spearman showed a high correlation (r=0.79, p<0.01), evidencing a direct dependence

of p53 expression level on HCC gradation.

Conclusion: HCC differentiation grade highly correlates with p53 expression level in immunopositive nuclei of HCC cells.

The obtained data evidences a dependence between p53 expression level and HCC gradation.
Multiple primary thyroid cancer
in combination with malignant paraganglioma
of the neck complicated by acute cerebrovascular
event in the postoperative period:
Clinical case
Authors: ADILBAYEV G. B. , KAIBAROV M. E. , KYDYRBAYEVA G. Z. , MYKHAMADIEV B. T. , SLONEVA N. V.
Published: September 2021

Actuality: Paraganglioma originates from the nerve ganglia along a.carotis, the ganglion of n.vagus, and the nerve plexuses around the sigmoid sinus, and has a rich tumor vasculature. Paraganglioma accounts for 0.8% of all CNS tumors and occurs

most often at 40-60 years. Chemodectoma is located in the common carotid artery bifurcation zone and accounts for 2/3 of all

glomus tumors.

Purpose: The article describes a clinical case of multiple primary thyroid cancer in combination with malignant paraganglioma of the neck complicated by acute cerebrovascular event (ACE) in the postoperative period treated at the Head and Neck

Tumor Department of the Kazakh Institute of Oncology and Radiology.

Results: The presented clinical case demonstrates the results of the treatment of multiple primary cancer complicated by

an ACE in the postoperative period. The qualification of doctors, adequate diagnostics contributed to choosing the right ACE

treatment tactics taking into account all the patient-specific features, the tumor localization, and possible postoperative complications.

Conclusion: The presented clinical case confirms the available data on the necessity of all diagnostic procedures and their

effectiveness in the assessment of the prevalence of the process and the involvement of the adjacent anatomical structures in

the suspected chemodectoma to avoid postoperative consequences that can lead to disability and fatal outcome. A wrong

choice of the volume of surgical intervention can result in severe postoperative complications. Timely diagnosis and knowledge

of the clinical course of the ACE helped restore the patient’s general condition and stop signs of cerebral ischemia. Successful

recovery of a patient depends on the qualifications of the doctors and the prevalence of the tumor process. Adequate symptomatic therapy has a huge impact on the course of a complicated postoperative period.
Interface Capturing for Multiphase Flows in PyFR
Authors: Al-Salami Jabir
Published: September 2021

Simulating multiphase flows requires capturing the sharp interface between different fluids. Carrying out such simulations using high-order methods is challenging due to the Gibbs phenomenon. The appearance of spurious oscillations in the vicinity of discontinuities and steep gradients makes it difficult to accurately resolve shocks and sharp interfaces. In this talk, an approach for interface capturing in PyFR using a preconditioned and localized phase-field model is presented. The accuracy of the interface normal vectors used in the phase-field model is improved by utilizing a preconditioning procedure based on the level set method with localized artificial viscosity stabilization. Kinematic numerical tests in 2D and 3D show that the developed approach significantly improves accuracy with little added computational effort, and yields better results when compared to similar methods. Dynamic interface capturing validation tests are carried out by coupling the proposed method to the entropically damped artificial compressibility method for solving the incompressible Navier–Stokes equations.
Jesús y los cínicos (II)
Authors: Mielgo Fernández Constantino
Published: September 2021

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Nietzsche, crítico y liberador del cristianismo: entre Diónisos y el Crucificado
Authors: Antolín Sánchez Javier
Published: September 2021

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La composición del De sancta uirginitate de san Agustín
Authors: Luis Vizcaíno Pío de
Published: September 2021

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Initiative for rare donor registry for A2/A2B subgroups with Rh phenotyping: A first of its kind
Authors: Mangwana Sadhana , Gohel Dolly , Kumar Shashi
Published: September 2021

Aims: Aim of this study is to create donor registry of A2/A2B subgroup blood donors with Rh and Kell phenotype, to provide transfusion to multi-transfused A2/A2B subgroup patients and to prevent adverse transfusion reaction due to immunological stimulation by pre-existing anti-A1 antibodies having enhanced titer and thermal amplitude. Prevalence of A2/A2B subgroup in Indian population is rare with highest prevalence of “e” antigen among the five Rh antigens, phenotyped serologically, and “E” antigen being the lowest in prevalence. Anti-A1 antibodies appear as cold agglutinins in A2/A2B individuals and can be clinically significant when reactive at 37 °C, causing hemolysis of A1 RBCs. Methods: A retrospective data analysis was done in a tertiary care hospital-based blood center at capital city of India from January 2016 to December 2020. All donors were subjected to ABO Rh grouping, Rh and Kell phenotyping by solid phase method. Tube technique was used to distinguish A2/A2B by agglutination reaction with anti-A1 lectin. Results: Total 40,051 donors were analyzed during study period, of which, A and AB groups constituted 21.26% and 9.01% respectively; out of these, only 0.47% belonged to A2 subgroup while A2B subgroup was more frequent (1.06%). The rarest Rh phenotypes found were R1Rz, r”r, r’r” in A2/A2B blood donors. Conclusion: There is a need to create rare donor registry for A2/A2B subgroups and clinically significant blood group antigens and share at various levels. This is a first small step to create a rare donor registry of A2/A2B subgroups with Rh and Kell phenotype, to provide transfusion to A2/A2B patients to prevent adverse transfusion reaction due to immunological stimulation by pre-existing anti-A1 antibodies having enhanced titer and thermal amplitude and to ensure improved quality of transfusion therapy.
Certain Classes of Meromorphic p-Valent Functions Associated with Mittag-Leffler Function
Authors: Aouf M. K. , Mostafa A. O. , Madian S. M.
Published: September 2021

In this paper, using definition of subordination and Mittag-Leffler function we introduce classes of p-valent meromorphic functions and obtain some subordination results for these classes.
Impacts of Covid-19 on Religious Seminaries & Educational Sectors of Pakistan: A Scholastic Approach
Authors: Butt Sadaf , Jaffar Saad , Haroon Zeenat
Published: September 2021

Corona Virus has become one of the most contagious pandemics of the 21st century, which has affected people all over the world. Economically stable countries have not suffered as much from the crises, but third-world countries are suffering greatly from the virus. Pakistan is currently facing financial, economic, and educational crises, on the other hand, people are losing their lives every day. This pandemic has not only created problems for students but also for the government. A staggering economy, growing poverty, and online learning were huge challenges. Marking strategies during online learning were totally absent and lack of student’s concentration increased the different problems. This research study has been conducting to analyze the impacts of the Corona Virus on Pakistan’s education and Madāris even Mosques were also devastated by the epidemic. The present study is also an attempt to elaborate on all those hurdles which appeared during online learning. This research comprises primary and secondary sources including government and official records, journals and books, etc. with an objective to find out the reasons for students' dropout rates along with the need for digital education in Pakistan. Lack of teachers training and unawareness of the new teaching methodologies are still the most noticeable challenges.
An Overview of the Halal Industry in the Gambia with Islamic Perspective: Challenges and Opportunities
Authors: Sanneh Kawsu , Kartika Betania
Published: September 2021

This study discusses an overview of the halal industry in The Gambia which is the smallest country in mainland Africa. Halal Industry has emerged as a new sector in the global economy, the industry is worth 2.3 trillion U.S Dollars. It is currently dominated by Southeast Asia with Malaysia and Indonesia taking the lead, followed by other continents like the United States of America, Europe, and Africa. Islam is believed to have been practiced in West Africa since the 7th Century amounting to over 12 centuries of Islamic influence in the region. The Gambia is a country with a 95 percent Muslim population, necessitating consumer awareness of halal products and services. There are currently no established halal education institutes in The Gambia, which has had a significant impact on Muslim consumers' awareness of halal standards, spanning from local farmers to food vendors, local consumers, processing industries, and importers. The lack of formal halal education institutions stands out as the most noticeable challenge. However, the vibrant Muslim population offers the highest opportunity. The paper is compiled from primary and secondary sources including government agencies, private firms, local consumers, journal articles, books, etc to find out the awareness of halal products, opportunities, and challenges.
Religious Concerns of Dowry and Marriage Gifts Regarding Determination of their Limits: Study of Malaysian law
Authors: Kamal Ahmad Haziq Haikal , Sitiris Miszairi , Razali Mohamad Afiq
Published: September 2021

In 2010, the Islamic religious department of a state in Malaysia issued a fatwa, which ruled that the dowry rate in the state would be regulated at a minimum value of RM300, with no indication of a maximum amount. In this instance, the community appears to be more concerned with the function of the provision of gift money, which is used solely to fund wedding expenses, rather than with the potential of dowry, which plays a more significant role for women. While this research does not challenge the fatwa’s decision, it does attempt to elucidate the issue of determining the minimum dowry rates from the perspective of fiqh and the Islamic Religious Administration Enactment. The library technique and inductive reasoning are by far the most often used ways of data collection by the author. On the whole, dowry has no specific limit while there are opinions of scholars on this, the setting of this dowry restriction, in particular, was never specified by Islām. People in the community misinterpret the meaning of the minimum and maximum limits, which leads to the low dowry and the high importance given to the provision of gift money.
Psychological Foundation of the Qur'an: Current Deterioration in Muslim Ummah
Authors: Tabassum Nabila
Published: September 2021

A review of the following English Edited book:
Shahid, Muhammad Shoiab (2016). Psychological Foundation of the Qur'an Current Deterioration in Muslim Ummah. Bloomington: Xlibris, 238 pp.
Riley e a Op Art
Authors: Pedro Martins de Almeida Manaia João
Published: September 2021

A exposição – “The Responsive Eye” - de 1965, no Museu de Arte Moderna de Nova Iorque, trouxe a projeção e o reconhecimento à Op Art e também a Bridget Riley. A estética de Bridget Riley, faz parte de um conjunto de práticas experimentais desenvolvidas durante o período pós-guerra, a partir das quais, alguns conceitos não representacionais são explorados e desenvolvidos. A sua arte foca-se em transportar até aos sentidos do observador, as forças imateriais de uma natureza subtil, recém-concebida; uma natureza comandada pela interação da luz, do calor e da energia; uma natureza Einsteiniana da dualidade de onda-partícula; uma natureza de forças invisíveis. Essa natureza, é revelada nos seus trabalhos, através de relações plásticas puras, agrupadas através de uma abordagem fenomenológica, que isola e amplia as formas e as relações essenciais. A sua prática representacional, passou por três estágios evolutivos, que se inter-relacionam: (1) compreensão da natureza da perceção humana, (2) representação da experiência visual e preceptiva da natureza, culminado com (3) a maneira pela qual o seu trabalho reflete a compreensão da natureza.
da Costa Alfarrabista
Authors: Ângelo Gonçalves Ângelo
Published: September 2021

A importância da representação gráfica de alfarrabistas do grande Porto é um conceito inovador, devido a existirem mais de dez alfarrabistas na região e poucos ou nenhuns usarem esta minuciosidade a seu proveito. Contudo, a afirmação da identidade através de um sistema gráfico permite distinção perante outros. Deste modo, o presente artigo expõe o processo de criação da comunicação corporativa da Moreira da Costa Alfarrabista. Esta livraria, loja centenária com 117 anos de vida, presenciou 5 gerações da mesma família e consta com mais de 30000 livros no seu espólio. Testemunhou quatro regimes, a monarquia, a 1ª república, ditadura e a 2ª república que vigora no presente. Atualmente, o crescimento do turismo no Porto trouxe uma nova dinâmica para lojas centenárias como a Moreira da Costa: os turistas. Por outro lado, o envelhecimento da população originou, consequentemente, uma subida da idade média dos clientes da Livraria. Posto isto, será necessário eleger um novo posicionamento de mercado que seja inerente ao novo sistema gráfico e vice-versa. Deste modo, propõe-se desenvolver um projeto de identidade visual para a Livraria Moreira da Costa que seja adequado às exigências contemporâneas da comunicação empresarial. É com base nesta intenção que se procura dotar o projeto com símbolos de coerência formal, conceptual, atual e estéticos assim como a capacidade de sedução na comunicação.
y el clarinete en los conservatorios de la Comunidad Autónoma de Madrid
Authors: FERNANDEZ COBO CARLOS JAVIER
Published: September 2021

La situación de la música de vanguardia dentro de los conservatorios ha estado muy condicionada tanto por los desarrollos legislativos de la enseñanza musical en estos centros, como por una serie de programaciones basadas en un repertorio barroco, clásico y decimonónico cuya finalidad era "conservar" una serie de estilos muy determinados que hacían necesaria la incorporación de un catálogo más moderno.Esta investigación estudia la visión de los profesores de conservatorio en la especialidad de clarinete de las posibilidades de la música de vanguardia dentro de la enseñanza en un conservatorio profesional de Música.Se pretende mostrar diferentes puntos de vista. A los profesores el conocimiento de la situación de los docentes. A los alumnos para poder mejorar la formación en este aspecto. A los compositores para incentivar la producción metodológica de enseñanza  y composiciones para ser incluidas en una programación anual.En un futuro dicho estudio podría ser extrapolable al resto de etapas educativas donde la asignatura de Música está presente, como en la educación primaria, secundaria o las escuelas de Música.
de Rua como agente da Identidade Local:
Authors: Seixosa Ana , Cadarso Maria
Published: September 2021

O presente estudo demonstra uma possível solução à crescente homogeneização do conceito de “lugar”, no que concerne às marcas e à sua publicidade exterior. Na perspetiva, aqui discutida, as marcas poderiam adotar elementos idiossincráticos da cultura das cidades nas suas campanhas, como forma de se integrarem no “lugar” onde estarão disponíveis, contribuindo para uma melhoria da experiência urbana. Esta abordagem é fundamentada através de uma investigação aplicada, realizada em três cidades japonesas (Kyoto, Osaka e Tokyo), e onde foram analisados aspetos sociológicos, culturais e estéticos da sociedade japonesa. Através de um estudo de campo com base em visual research, foram constituídas amostras distintas para cada cidade, compostas por 180 objetos cada, e examinadas em três fases sequenciais: análise descritiva, análise de conteúdo e análise interpretativa. Os resultados encontrados corroboram as hipóteses levantadas relativas à existência de preferências culturais divergentes na publicidade de rua de cada uma destas três cidades.
no processo artístico de criação nas artes plásticas
Authors: Monteiro Ilda
Published: September 2021

O presente estudo, tendências no processo artístico de criação nas artes plásticas, pretende trasmitir o conhecimento da temática, com características específicas e diversificadas que se completam entre si.  Na criação pictórica, a ação do artista modifica a obra em várias fases, que se finalizam a partir de questões, que por sua vez, respondem à experiência do criador.
Na área das artes plásticas os procedimentos criativos também estão relacionados com o momento histórico, aspectos sociais, culturais e tecnológicos em que o artista se insere. O principal objetivo do estudo é a análise das técnicas e os resultados no processo criativo, tendo como base a produção do artista, que tiveram um papel construtivo e expressivo e condicionaram o resultado estético / plástico da obra, à semelhança de qualquer outra tecnologia utilizada para determinado objecto artístico. Este trabalho apresenta métodos e técnicas das tendências verificadas a partir da exploração do artista, o qual questiona todo o processo criativo da obra. O ready-made duchampiano surge como concretização, reavalia o papel do artista e o modo como este interage com o objecto artístico, com as instituições e com o público especializado de encontro à contemporaneidade da arte.
culturais
Authors: Costa Maria Luísa
Published: September 2021

Encontrar o caminho faz parte das necessidades ancestrais do ser humano, como se pode entender de um breve olhar sobre a evolução da sinalética e dos recursos utilizados pelo homem para facilitar o acesso a diferentes lugares. Os objetivos e os métodos diferem, de acordo com as necessidades sociais e culturais e os meios disponíveis em cada época. Hoje, promover o acesso ao conhecimento e fruição do Património é uma necessidade resultante dos processos de globalização e da vontade de manter a sociedade plural e diversa. Neste sentido, promover o diálogo entre Património Material e Imaterial por via de rotas culturais, comunicadas através do design de sistemas wayfinding, constitui uma necessidade para o pleno entendimento de ambos. Assim, o presente artigo aborda a questão da evolução da sinalética, do conceito de Património e da necessidade de promoção do diálogo entre o património material e imaterial, refletindo sobre as diferentes formas de acesso à informação em contexto de sistemas wayfinding.