bluuebunny/crossref_metadata_2025 huggingface dataset:
Det dubbla utanförskapet
Authors: Lagerlöf Hélène
Published: July 2020

A twofold exclusion – interviews about bullying with young people in residential careYouth in residential care are at risk of living in twofold exclusion when stigmatization and bullying in school become part of their everyday life. The article presents results from semi-structured interviews with ten young people in residential care. The young people’s reflections on bullying are analysed in relation to different explanatory models of bullying. Experiences of bullying are very common among youth placed in out of home care, which calls for research on bullying and youth in residential care. The aim of the study was to present understandings of bullying among youth placed in residential care and to investigate why youth in residential care report victimization to a higher degree than young people living at home. The research questions were: 1. What descriptions do young people give of the term bullying? 2. What insights can the young people’s descriptions of bullying give to the high victimization among youth in residential care? 3. How can the young people’s descriptions of bullying be understood in relation to different understandings of bullying? The main findings are the young people’s sense of exclusion. They feel stigmatized due to their placement in care and believe they have to be secretive in school about being placed in care because of the risk of bullying. Three suggestions to decrease the twofold exclusion are presented. 1. Based on knowledge that frequent changes in groups are a risk factor in regard to bullying, placement changes need to be reduced to a minimum. 2. Schools (teachers and pupils) need education concerning care environments. 3. Young people are often placed in care due to behavioural problems and therefore residential units need advantageous conditions to work with the young people’s behaviour on both individual and group level.
Från den ”sionistiska ockupationsregimen” till ”judisk makt”
Authors: Lööw Heléne
Published: July 2020

From the ”Zionist occupational government” to ”the Jewish power” – anti-Semitism within the Nordic Resistance MovementThe focus of the study has been on how anti-Semitism is expressed within the Nordic Resistance Movement (NMR), what language is used, in which contexts it occurs and what changes may have taken place. Anti-Semitism has always been the foundation of the NMR’s ideology, regardless of the name of the organization, or how they have chosen to define their ideology. Over the years, anti-Semitism has been expressed in different ways and with varying degrees of openness. During the 1990s, anti-Semitism was open and activist, but during the 2000s it somehow, diminished in terms of language use. During this period, the organization reverted, to a great extent, to the anti-Semitic code language of the earlier decades. Of course, this does not mean that anti-Semitism in any way lost its significance, only that it was expressed in a different way. During the 2010s, anti-Semitism has again become open, the use of the code language less and less frequent. Anti-Semitism within NMR is also strongly linked to practical activism in the form of various anti-Semitic actions and demonstrations. Although various actions are not at first sight perceived as anti-Semitic, they often are anti-Semitic. This applies, for example, to symbolic actions where various individuals, for example, on placards at demonstrations, are designated as ”traitors”. Some may be Jews, others not, but they are all seen as symbols of a ”Jewish power”, a kind of parade of ”Jews” and ”Spiritual Jews” which symbolize the supposed ”Jewish power” that NMR is fighting. We see here both ideology and practical action. In recent years, NMR has also increasingly returned to its origins, i.e. the Swedish national socialists during the interwar period, this is reflected in the language used and the importance attached to the history of the movement in a wider perspective. The NMR’s anti-Semitism is also an everyday anti-Semitism, in that it permeates the activists’ lives, how they interpret what is happening in the outside world. In the NMR, anti-Semitism is an everyday practice, to reconnect with Fein’s definition of anti-Semitism.
Familjen i välfärdspolitiken
Authors: Stanfors Maria
Published: July 2020

The role of the family in Swedish welfare policyIn the present article, I discuss the role of the family in Swedish welfare policy, from both theoretical and empirical perspectives. I analyse men’s and women’s time use and focus on the organization of paid and unpaid work. I describe how time allocation varies with gender, family status, and life cycle. The analysis shows that the family plays a more important role in practice than in theory, mainly through the fact that women perform more unpaid work (housework and caregiving) than men, which affects both their income and their well-being negatively. I argue that gender equality must be given a more prominent position in Swedish welfare policy. For example, family policy must be reformed, with gender equality on the labour market and in the home as an explicit goal. The present situation for working parents is different from that of previous decades when Swedish family policy was formulated. Reforms are thus necessary for safeguarding welfare and population well-being in the short and long run.
Automatisering – till nytta eller fördärv?
Authors: Svensson Lupita
Published: July 2020

Automation to benefit or ruin?The purpose of this article is to discuss and analyze how digital automation of the provision of social assistance affects the practice of social work, as part of welfare. Based on interviews with supervisors/project managers and social case workers, who work with social assistance in a strategic selection of municipalities, the opportunities and challenges that robotization brings to the function of social assistance are problematized as a selective welfare right. The results show that robotisation can help to increase efficiency and that resources can be re-prioritized, but at the same time there are significant risks to the erosion of the social work practice, both in terms of the practitioners’ work in the provision of social assistance and its function as a selective right in a universal welfare construction. The results also indicate needs for further in-depth studies.
Nya böcker
Authors: Denvall Verner
Published: July 2020

What works now? Evidence-informed policy and practice.Boaz, Annette; Davies, Huw; Fraser, Alec & Nutley, Sandra (2019)Bristol: Policy Press.
Impacted Coin in Esophagus in a 5 year Old Child
Authors: Khan Mushtaq
Published: July 2020

Foreign body ingestion is more common in children than in adults. Coin is the most common foreign body impaction seen in children and usually occurs at the level of Cricopharynx.
Analysis of the Possibilities of Using a Driver’s Brain Activity to Pneumatically Actuate a Secondary Foot Brake Pedal
Authors: Dindorf Ryszard , Wos Piotr
Published: July 2020

The study deals with the use of the driver’s brain activity for wireless remote control of the pneumatic actuator exerting pressure on the secondary foot brake pedal. The conducted experimental tests confirm that bioelectrical signals (BES) induced by muscle tension within the head can be used for wireless remote control of a pneumatic actuator to exert a pressure force on a foot brake pedal for disabled drivers during car emergency braking. It has been shown that the BES artefacts generated by muscular tension inside the head (e.g., movement of the face and eyelids, clenching of jaws, and pressing the tongue on the palate) are the easiest to control of the pneumatic systems. The proposed car braking assistance system controlled by the driver’s brain activity can improve the driving safety of disabled people, e.g., by reducing the reaction time of pneumatically assisted emergency braking.
Evaluation of Tropical Tomato for Growth, Yield, Nutrient, and Water Use Efficiency in Recirculating Hydroponic System
Authors: Williams Ayarna Alex , Tsukagoshi Satoru , Oduro Nkansah George , Lu Na , Maeda Kazuya
Published: July 2020

The issue of low tomato production in the tropics like Ghana has been a long-standing challenge. The advent of greenhouse technology has not significantly improved the yield of tomato compared to Japan and the Netherlands. Immediate technological interventions are needed. Through hydroponics, the low-node order pinching at a high-density planting system has been recommended in some studies. This system was intended to be established in Ghana, and it would be expected to improve the yield and fruit quality of tomato. In effect, a study was carried out in the greenhouse, at Chiba University using this system. A tropical tomato cultivar (Jaguar) was evaluated with Momotaro York at 3.8 m s2 and pinched at the fourth truss. Data collected were water and nutrient use efficiencies, plant growth rate, dry matter partitioning, and fruit yield and quality, as well as some physiological characteristics. The experiment was laid out in a randomized complete block design with three replications. Results showed that Jaguar cultivar was two times more efficient in water and nutrient use than Momotaro York at first harvest. Root tissue density recorded in Jaguar was significantly lower compared to Momotaro York. The net assimilation rate (NAR) recorded was markedly higher in Jaguar than Momotaro York at last harvest. All the physiological attributes recorded in both cultivars were not significantly different. Plant dry mass (DM) recorded was similar in the two cultivars; however, the DM partitioned to fruits was 55% in Jaguar compared to 46.5% DM for Momotaro York. Fruit yield per area did not differ in the two cultivars. Fruit yields of 28.8 and 30 kg m−2 per year were recorded in Jaguar and Momotaro York, respectively. In comparison, this yield result is 1.2–1.25 times less and 14.4–15 times higher than current tomato yields recorded in Japan (greenhouse) and Ghana, respectively. Fruit quality, in terms of total soluble solids recorded in Jaguar cultivar being 5.4 %Brix, was within the 3.5–5.6 %Brix recorded in Ghana. This system could effectively enhance the yield and quality of tomato in the tropics as well as economising on the use of resources.
Audacious Hitchhikers: The Role of Travel and the International Food Trade in the Global Dissemination of Mobile Colistin-Resistance (mcr) Genes
Authors: Hassan Jouman , Kassem Issmat I.
Published: July 2020

Colistin, a last-resort antibiotic, has been used in controlling infections caused by multidrug-resistant Gram-negative bacterial pathogens. However, recent reports showed a global dissemination of mobile colistin-resistance (mcr) genes, genetic elements that encode resistance to colistin, which has raised public health concerns. These mcr genes threaten the effectiveness of colistin and could limit therapy options for complicated infections. Despite global attention, many facets of the molecular epidemiology of mcr remain poorly characterized. Here, we focus on the role of travel and the international food trade in the dissemination of mcr to countries where these genetic elements and/or colistin resistance are relatively limited in prevalence. We present evidence from the literature on the acquisition of mcr during travel, and the carriage of these genes back to travelers’ countries. We also highlight the potential transmission of mcr via imported foods. These observations emphasize the magnitude of efforts that are needed to control the spread of mcr, and further highlight the challenge of antimicrobial resistance and the urgent need for coordinated global action.
Antioxidant Activity Modulated by Polyphenol Contents in Apple and Leaves during Fruit Development and Ripening
Authors: Wojdyło Aneta , Oszmiański Jan
Published: July 2020

Apples (Malus domestica Borkh) are of particular interest for their high content of healthy phytochemicals. This study investigated the antioxidant activity and polyphenolic compounds of extracts from the fruits from Ozark Gold, Starkinson and Kosztela cultivars and additionally leaves from Ozark Gold cv. Phenolic compounds were identified and quantified by liquid chromatography- mass spectrometer (LC–MS) and high pressure liquid chromatography (HPLC). The samples were collected during fruit development at 60, 80, 130 and 145 days after full bloom. The concentration of apple phenolics was highest early in the season and decreased during fruit development. The leaf phenolics had a more steady level during all the period of collection than the fruits. Among the five groups of analyzed polyphenols, the procyanidins predominated in apple fruits and dihydrochalcones in leaves. The concentration of polyphenols decreased from 39.15, 5.97 and 33.39 g/kg dw (collected at 60 days after full bloom) to 14.22, 2.05 and 9.31 g/kg dw (collected at 145 days after full bloom) for apples Ozark Gold, Starkinson, Kosztela, respectively. The leaves characterized a much higher content of polyphenolic compounds and antioxidant capacity than unripe fruits. Antioxidant capacity measured by 2,2-azinobis-(3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenyl-picrylhydrazyl (DPPH) methods was higher when the apple was unripe and the leaves were young. The results indicate that, unripe fruits and leaves are very good raw material for polyphenol nutraceutical production with high antioxidant potential.
Innovative and Conventional Valorizations of Grape Seeds from Winery By-Products as Sustainable Source of Lipophilic Antioxidants
Authors: Dimić Ivana , Teslić Nemanja , Putnik Predrag , Bursać Kovačević Danijela , Zeković Zoran , Šojić Branislav , Mrkonjić Živan , Čolović Dušica , Montesano Domenico , Pavlić Branimir
Published: July 2020

The aim of this study was to valorize the oil recovery from red and white grape seeds (Vitis vinifera L.) that remains as by-product after the winemaking process. Oils were extracted by modern techniques, ultrasound assisted (UAE), microwave assisted (MAE) and supercritical fluid extraction (SFE), and compared to the Soxhlet extraction (SE). Firstly, SFE was optimized at different operating conditions: pressure (250–350 bar), temperature (40–60 °C), CO2 flow rate (0.2, 0.3 and 0.4 kg h−1), and particle size (315–800 µm and >800 µm). The highest extraction yields were achieved by SFE at the optimal conditions: 350 bar, 60 °C, 0.4 kg h−1. Afterwards, SFE was compared to SE, UAE and MAE with respect to oil extraction yields, and analyzed for fatty acid composition and antioxidant capacity. Considering the general classification of fatty acids, it was found that samples had high content of polyunsaturated fatty acids, regardless of extraction technology. Tocopherol content was significantly influenced by all extraction methods, whereas UAE and MAE resulted in extracts richer with lipophilic antioxidants. In conclusion, modern extractions that are suited for industrial applications had better performance as compared to SE, as judging by the oil yield and quality.
Changes in Oxidative Stress, Inflammation, and Muscle Damage Markers Following Diet and Beetroot Juice Supplementation in Elite Fencers
Authors: Kozłowska Lucyna , Mizera Olga , Gromadzińska Jolanta , Janasik Beata , Mikołajewska Karolina , Mróz Anna , Wąsowicz Wojciech
Published: July 2020

The aim of this study was to assess the impact of diet and active substances in beetroot juice on the parameters of oxidative stress, inflammation, and muscle damage as well as on the maximum rate of oxygen uptake (VO2max) in elite fencers (10 women, 10 men). Athletes during four weeks realized dietary recommendations (ID) and, after that, diet with freeze-dried beetroot juice supplementation (ID&BEET). At baseline and after each stage, fasting antioxidants, biomarkers of oxidative stress, inflammation, and skeletal muscle damage were measured, and a VO2max test was performed. Only after ID&BEET was a significant increase of VO2max observed, and changes of this parameter were negatively related with changes of serum lactate dehydrogenase (∆LDH) activity, as well as with serum ∆β-carotene and malondialdehyde concentration (∆MDA). Additionally, positive relationships were observed between ∆β-carotene versus changes of the serum concentration of advanced oxidation protein products (∆AOPP), changes of serum glutathione peroxidase activity (∆GPx3) versus both changes of physical activity level and ∆LDH, as well as erythrocyte glutathione peroxidase activity (∆GPx1) versus ∆LDH. To summarize, we showed that long-term beetroot juice supplementation increases lipid peroxidation, and improvement of VO2max after ID&BEET seems to be dependent on LDH activity, as well as on the serum concentration of MDA and β-carotene.
Polyphenols Attenuate Highly-Glycosylated Haemoglobin-Induced Damage in Human Peritoneal Mesothelial Cells
Authors: Sánchez-Rodríguez Carolina , Peiró Concepción , Rodríguez-Mañas Leocadio , Nevado Julián
Published: July 2020

We investigated the cytoprotective role of the dietary polyphenols on putative damage induced by Amadori adducts in Human Peritoneal Mesothelial Cells (HPMCs). Increased accumulation of early products of non-enzymatic protein glycation—Amadori adducts—in the peritoneal dialysis fluid due to their high glucose, induces severe damage in mesothelial cells during peritoneal dialysis. Dietary polyphenols reportedly have numerous health benefits in various diseases and have been used as an efficient antioxidant in the context of several oxidative stress-related pathologies. HPMCs isolated from different patients were exposed to Amadori adducts (highly glycated haemoglobin, at physiological concentrations), and subsequently treated with several polyphenols, mostly presented in our Mediterranean diet. We studied several Amadori-induced effects in pro-apoptotic and oxidative stress markers, as well as the expression of several pro-inflammatory genes (nuclear factor-kappaB, NF-kB; inducible Nitric Oxide synthetase, iNOS), different caspase-activities, level of P53 protein or production of different reactive oxygen species in the presence of different polyphenols. In fact, cytoprotective agents such as dietary polyphenols may represent an alternate approach to protect mesothelial cells from the cytotoxicity of Amadori adducts. The interference with the Amadori adducts-triggered mechanisms could represent a therapeutic tool to reduce complications associated with peritoneal dialysis in the peritoneum, helping to maintain peritoneal membrane function longer in patients undergoing peritoneal dialysis.
Beam Pre-Shaping Methods Using Lenslet Arrays for Area-Based High-Resolution Vehicle Headlamp Systems
Authors: Li Yang , Knöchelmann Marvin , Lachmayer Roland
Published: July 2020

High-resolution light distributions are lately in demand for vehicle headlamp systems as an innovative lighting approach. This lighting approach can realize functionalities, such as precise glare avoidance and on-road projection, which are useful for improving traffic comfort and safety. For achieving the required high-resolution light distribution, area-based projection technologies, such as DMD, LCD, and LCoS, are considered to be integrated into such headlamps. These projection devices demand rectangular illumination areas with specific light distributions to fulfill the requirements for illumination efficiency and performance in headlamp systems. Lenslet arrays, based on the principle of Köhler illumination, can effectively homogenize the light and shape it into rectangular shapes simultaneously. Such components are widely used in projection applications. However, they also show functional potentialities to be applied in high-resolution headlamps. This paper explains the design principles and methods of lenslet arrays for beam pre-shaping in headlamp systems. It validates the homogenization using a self-designed and manufactured lenslet array in a demonstrator in the first place. Afterward, this paper introduces two new methods for the centralized beam shaping required by some headlamps. These methods are validated by optical simulations.
An Initial Model for Zero Defect Manufacturing
Authors: Lindström John , Kyösti Petter , Birk Wolfgang , Lejon Erik
Published: July 2020

This paper investigates an initial model for Zero Defect Manufacturing (ZDM) using a cost function where the operation and condition of a production process are reflected, and the quality of the output/product and the production process (as well as safety aspects) can be considered. The outset of the study is based on empirical data collected from five manufacturing companies, and proposes an initial model for ZDM with an Industry 4.0 perspective. The initial ZDM model has a generic setup for a real-life system and its replication as a digital twin using system models based on a representation of a generic production process with its connected control system, and potential interconnections between unit processes. It is based on concepts from system theory of dynamic systems and principles from condition monitoring and fault detection. In that way the model is deemed as highly generalizable for manufacturing and process industry companies as well as for some critical infrastructures with production and distribution systems. The proposed model with its cost function setup is analyzed and discussed in the context of ZDM. It is concluded that production processes in the manufacturing and process industry can be made more intelligent and interoperable using this approach. Improved sustainability, competitiveness, efficiency and profitability of companies are foreseen welcomed secondary effects. Finally, the proposed ZDM model further develops the ZDM by adding to it a systematic approach based on a solid mathematical foundation.
Evaluation of the Microstructure and the Electrochemical Properties of Ce0.8(1−x)Gd0.2(1−x)CuxO[1.9(1−x)+x] Electrolytes for IT-SOFCs
Authors: Accardo Grazia , Bae Jae Kwan , Yoon Sung Pil
Published: July 2020

The influence of copper addition (0.5–2 mol%) on the crystal structure, densification microstructure, and electrochemical properties of Ce0.8Gd0.2O1.9 synthesized in a one-step sol–gel combustion synthesis route has been studied. It has been found that Cu is very active as sintering aids, with a significative reduction of GDC firing temperature. A reduction of 500 °C with a small amount of copper (0.5 mol%) was observed achieving dense bodies with considerable ionic conductivities. Rietveld refined was used to investigate the crystal structure while relative density and microstructural examination were performed in the sintering temperature range of 1000–1200 °C after dilatometer analysis. High dense bodies were fabricated at the lowest sintering temperature, which promotes the formation of Ce0.8(1−x)Gd0.2(1−x)CuxO[1.9(1−x)+x] solid solution and the absence of secondary phase Cu-rich or the segregation or copper at the grain boundary. As compared to the pure GDC an improvement of total conductivity was achieved with a maximum for the highest copper content of 2.23·10−3–9.19·10−2 S cm−1 in the temperature range of 200–800 °C.
The Potential of Nano-Porous Surface Structure for Pain Therapeutic Applications: Surface Properties and Evaluation of Pain Perception
Authors: Wu Ching-Zong , Hsu Ling-Chuan , Chou Hsin-Hua , Barnkob Sanne , Eggert Tobias , Nielsen Pernille Lind , Young Roger , Vase Lene , Wang Kelun , Svensson Peter , Ou Keng-Liang , Baad-Hansen Lene
Published: July 2020

The objective of this study was to evaluate the biomaterial properties of nano-modified surface acupuncture needles and the effect of such needles on human pain perception by using pressure pain threshold (PPT) measurements. It is known that changing a material’s surface nano-topography or nanostructure has strong effects on its physical, chemical, and biological surface properties. However, there is no information in the literature about the stimulation characteristics of acupuncture needles with nano-topography or nanostructured surfaces. Based on the knowledge on nanostructured surfaces, it may be possible to potentiate the effects of acupuncture needle stimulation. The pressure pain sensitivity of the masseter muscle in the orofacial region was studied in 21 healthy volunteers in two randomized, double-blinded sessions: an active session of manual acupuncture manipulation with nano-modified surface needles, and an inactive session of sham acupuncture stimulation to control for possible placebo effects. Three acupuncture points were selected from classical Chinese medicine literature: LI4 (Hegu) on the hand, ST6 (Jiache) on the lower masseter region, and ST7 (Xiaguan) on the upper masseter region. PPT measurements, perceived sensations, and pain from the acupuncture were recorded. The results showed discrete yet significant differences in PPT values between the active and inactive acupuncture treatments and significantly higher pain scores from active acupuncture stimulation than from sham acupuncture. These results indicate subtle but significant effects of acupuncture stimulation with nano-modified surface needles, compared to sham acupuncture in healthy participants.
A Visualization System for Exploring Logo Trend and Design Shape Patterns
Authors: Ha Hyoji , Han Hyunwoo , Lee Kyungwon
Published: July 2020

A logo is an effective way of expressing a brand’s identity and an essential element in conveying the values and image of the company. The development process of a competitive logo should be based on a design that is future-proof in a rapidly changing global market; hence, understanding the design trends for successful logo design is key. In this study, the design shape elements of logo trend models were analyzed and made into a database. Then, a trend analysis system was produced using radial visualization (RadViz) and circular parallel coordinates data visualization techniques. RadViz allows observation of clusters of logos that have similar shape elements, whereas with circular parallel coordinates plots, detailed information of the shape elements of each logo trend can be seen. Using the system, it was confirmed that shape elements—such as transformation to surface, overlapping, artificiality, concept of color and rhythm—play a major role in driving a trend. It was observed that trends change over time as various shape elements are added or removed. In addition, our study is expected to help predict the logo trend models that will come into style in the future. While similar efforts have been made in the past, our proposed system improves upon them by utilizing standard design elements as the categorizing criteria, using a unique combination of RadViz and circular parallel coordinates data visualization techniques. Using our system as a guideline, many users would be able to create logos that reflect what is trending.
A Comparative Analysis for Air Quality Estimation from Traffic and Meteorological Data
Authors: Arnaudo Edoardo , Farasin Alessandro , Rossi Claudio
Published: July 2020

Air pollution in urban regions remains a crucial subject of study, given its implications on health and environment, where much effort is often put into monitoring pollutants and producing accurate trend estimates over time, employing expensive tools and sensors. In this work, we study the problem of air quality estimation in the urban area of Milan (IT), proposing different machine learning approaches that combine meteorological and transit-related features to produce affordable estimates without introducing sensor measurements into the computation. We investigated different configurations employing machine and deep learning models, namely a linear regressor, an Artificial Neural Network using Bayesian regularization, a Random Forest regressor and a Long Short Term Memory network. Our experiments show that affordable estimation results over the pollutants can be achieved even with simpler linear models, therefore suggesting that reasonably accurate Air Quality Index (AQI) measurements can be obtained without the need for expensive equipment.
Performance of Forecasts of Hurricanes with and without Upper-Level Troughs over the Mid-Latitudes
Authors: Sato Kazutoshi , Inoue Jun , Yamazaki Akira
Published: July 2020

We investigated the accuracy of operational medium-range ensemble forecasts for 29 Atlantic hurricanes between 2007 and 2019. Upper-level troughs with strong wind promoted northward movement of hurricanes over the mid-latitudes. For hurricanes with upper-level troughs, relatively large errors in the prediction of troughs result in large ensemble spreads, which result in failure to forecast hurricane track. In contrast, for hurricanes without upper-level troughs, mean central position errors are relatively small in all operational forecasts because of the absence of upper-level strong wind around troughs over the mid-latitudes. Hurricane Irma in September 2017 was accompanied by upper-level strong wind around a trough; errors and ensemble spreads for the predicted upper-level trough are small, contributing to smaller errors and small ensemble spreads in the predicted tracks of Irma. Our observing system experiment reveals that inclusion of additional Arctic radiosonde observation data obtained from research vessel Mirai in 2017 improves error and ensemble spread in upper-level trough with strong wind at initial time for forecast, increasing the accuracy of the forecast of the track of Irma in 2017.
Climatology of Tropospheric Relative Humidity over the Korean Peninsula from Radiosonde and ECMWF Reanalysis
Authors: Song Hwan-Jin , Kim Sunyoung , Lee Hyesook , Kim Ki-Hoon
Published: July 2020

Conventional radiosondes can be used to measure the relative humidity over liquid (RHL) by assuming a saturated vapor pressure over the liquid. However, this assumption results in significant errors with respect to measurements in the upper troposphere, where the effect of ice is dominant. Therefore, this study presents a novel method that considers the effects of ice to determine the relative humidity from radiosonde RHL data for the last 40 years (1979–2018) over the upper layers of the Korean peninsula. Even though the relative humidity obtained from the reanalysis data was significantly different from the radiosonde-based RHL, the difference was much reduced when relative humidity was calculated using the novel method proposed in this study. Such improvements in the estimated relative humidity could be attributed to the consideration of the ice effect at temperatures above freezing level. Additionally, the validity of the relative humidity estimated in this study was established based on a two-week case analysis of data from Boseong station. Furthermore, two peak relative humidity modes for the lower and upper layers were clearly identified in the mean climatology profiles, which indirectly suggested the absence of mid-level clouds around the 700-hPa level and 500-hPa level in winter and summer, respectively. This study is meaningful as it is the first study to determine the relative humidity distribution over the Korean peninsula using radiosonde observations. The scientific value obtained can potentially be expanded by applying the proposed method to other radiosonde observation networks, which are widely distributed worldwide.
On the Periodicity of General Class of Difference Equations
Authors: Moaaz Osama , Mahjoub Hamida , Muhib Ali
Published: July 2020

In this paper, we are interested in studying the periodic behavior of solutions of nonlinear difference equations. We used a new method to find the necessary and sufficient conditions for the existence of periodic solutions. Through examples, we compare the results of this method with the usual method.
Characterization of Key Aroma Compounds in Xiaoqu Liquor and Their Contributions to the Sensory Flavor
Authors: Wang Zhe , Sun Xizhen , Liu Yuancai , Yang Hong
Published: July 2020

The objective of this study was to investigate the aroma profile and major flavor compounds in Xiaoqu liquor by a combination of sensory profiling, GC-O/GC-MS analysis, and SBSE-GC-MS. A total of 57 important volatile compounds (FD ≥ 2) were screened based on the retention indices, aromatic characteristics, standard comparison, and aroma extract dilution analysis (AEDA). By calculating the odor activity values (OAVs), 32 aroma active compounds were identified in Xiaoqu liquor. In the aroma recombination experiments, these active compounds were dissolved in 46% ethanol water at their natural concentrations, resulting in successful simulations of the typical aromas of Xiaoqu liquor, including fruity aroma, sweet aroma, and grain aroma. Omission experiments showed that the critical compounds that contribute to the characteristic flavor of Xiaoqu liquor include ethyl octanoate, acetaldehyde, 1,1-diethoxyethane, isoamyl acetate, ethyl acetate, valeric acid, 1-octen-3-ol, and ethyl isovalerate. The results provide some guidance for upgrading the fermentation and microbial strain in the production of Xiaoqu liquor.
Additive Biomanufacturing with Collagen Inks
Authors: Chan Weng Wan , Yeo David Chen Loong , Tan Vernice , Singh Satnam , Choudhury Deepak , Naing May Win
Published: July 2020

Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes allow control of physical and chemical properties such as mechanical stiffness, viscosity and biodegradability. Moreover, various additive biomanufacturing technology has enabled layer-by-layer construction of complex structures to support biological function. Additive biomanufacturing has expanded the use of collagen biomaterial in various regenerative medicine and disease modelling application (e.g., skin, bone and cornea). Currently, regulatory hurdles in translating collagen biomaterials still remain. Additive biomanufacturing may help to overcome such hurdles commercializing collagen biomaterials and fulfill its potential for biomedicine.
Hapten Design and Monoclonal Antibody to Fluoroacetamide, a Small and Highly Toxic Chemical
Authors: Yang Ling , Zhang Xiya , Shen Dongshuai , Yu Xuezhi , Li Yuan , Wen Kai , Shen Jianzhong , Wang Zhanhui
Published: July 2020

Fluoroacetamide (FAM) is a small (77 Da) and highly toxic chemical, formerly used as a rodenticide and potentially as a poison by terrorists. Poisoning with FAM has occurred in humans, but few reliably rapid detection methods and antidotes have been reported. Therefore, producing a specific antibody to FAM is not only critical for the development of a fast diagnostic but also a potential treatment. However, achieving this goal is a great challenge, mainly due to the very low molecular weight of FAM. Here, we design two groups of FAM haptens for the first time, maximally exposing the fluorine or amino groups, with the aid of linear aliphatic or phenyl-contained spacer arms. Interestingly, whereas the hapten with fluorine at the far end of the hapten did not induce an antibody response to FAM, the hapten with an amino group at the far end and phenyl-contained spacer arm triggered a significantly specific antibody response. Finally, a monoclonal antibody (mAb) named 5D11 was successfully obtained with an IC50 value of 97 μg mL−1 and negligible cross-reactivities to the other nine functional and structural analogs.
The Nuclear Lamina: Protein Accumulation and Disease
Authors: Almendáriz-Palacios Carla , Gillespie Zoe E. , Janzen Matthew , Martinez Valeria , Bridger Joanna M. , Harkness Troy A. A. , Mousseau Darrell D. , Eskiw Christopher H.
Published: July 2020

Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging. One proteinaceous structure underlying the nuclear envelope—the nuclear lamina—coordinates essential processes including DNA repair, genome organization and epigenetic and transcriptional regulation. Loss of proteostasis within the nuclear lamina results in the accumulation of proteins, disrupting these essential functions, either via direct interactions of protein aggregates within the lamina or by altering systems that maintain lamina structure. Here we discuss the links between proteostasis and disease of the nuclear lamina, as well as how manipulating specific proteostatic pathways involved in protein clearance could improve cellular health and prevent/reverse disease.
The Role of FAT10 in Alcoholic Hepatitis Pathogenesis
Authors: Jia Yue , Ji Ping , French Samuel W.
Published: July 2020

FAT10 expression is highly up-regulated by pro-inflammatory cytokines IFNγ and TNFα in all cell types and tissues. Increased FAT10 expression may induce increasing mitotic non-disjunction and chromosome instability, leading to tumorigenesis. In this review, we summarized others’ and our work on FAT10 expression in liver biopsy samples from patients with alcoholic hepatitis (AH). FAT10 is essential to maintain the function of liver cell protein quality control and Mallory–Denk body (MDB) formation. FAT10 overexpression in AH leads to balloon degeneration and MDB aggregation formation, all of which is prevented in fat10-/- mice. FAT10 causes the proteins’ accumulation, overexpression, and forming MDBs through modulating 26s proteasome’s proteases. The pathway that increases FAT10 expression includes TNFα/IFNγ and the interferon sequence response element (ISRE), followed by NFκB and STAT3, which were all up-regulated in AH. FAT10 was only reported in human and mouse specimens but plays critical role for the development of alcoholic hepatitis. Flavanone derivatives of milk thistle inhibit TNFα/IFNγ, NFκB, and STAT3, then inhibit the expression of FAT10. NFκB is the key nodal hub of the IFNα/TNFα-response genes. Studies on Silibinin and other milk thistle derivatives to treat AH confirms that overexpressed FAT10 is the major key molecule in these networks.
The Sustained Attention to Response Task Shows Lower Cingulo-Opercular and Frontoparietal Activity in People with Narcolepsy Type 1: An fMRI Study on the Neural Regulation of Attention
Authors: Gool Jari K. , van der Werf Ysbrand D. , Lammers Gert Jan , Fronczek Rolf
Published: July 2020

Vigilance complaints often occur in people with narcolepsy type 1 and severely impair effective daytime functioning. We tested the feasibility of a three-level sustained attention to response task (SART) paradigm within a magnetic resonance imaging (MRI) environment to understand brain architecture underlying vigilance regulation in individuals with narcolepsy type 1. Twelve medication-free people with narcolepsy type 1 and 11 matched controls were included. The SART included four repetitions of a baseline block and two difficulty levels requiring moderate and high vigilance. Outcome measures were between and within-group performance indices on error rates and reaction times, and functional MRI (fMRI) parameters: mean activity during the task and between-group activity differences across the three conditions and related to changes in activation over time (time-on-task) and error-related activity. Patients—but not controls—made significantly more mistakes with increasing difficulty. The modified SART is a feasible MRI vigilance task showing similar task-positive brain activity in both groups within the cingulo-opercular, frontoparietal, arousal, motor, and visual networks. During blocks of higher vigilance demand, patients had significantly lower activation in these regions than controls. Patients had lower error-related activity in the left pre- and postcentral gyrus. The time-on-task activity differences between groups suggest that those with narcolepsy are insufficiently capable of activating attention- and arousal-related regions when transitioning from attention initiation to stable attention, specifically when vigilance demand is high. They also show lower inhibitory motor activity in relation to errors, suggesting impaired executive functioning.
Gene Pair Correlation Coefficients in Sphingolipid Metabolic Pathway as a Potential Prognostic Biomarker for Breast Cancer
Authors: Sakharkar Meena Kishore , Kaur Dhillon Sarinder , Chidambaram Saravana Babu , Essa Musthafa Mohamed , Yang Jian
Published: July 2020

Complex diseases such as cancer are usually governed by dynamic and simultaneous modifications of multiple genes. Since sphingolipids are potent bioactive molecules and regulate many important pathophysiological processes such as carcinogenesis, we studied the gene pair correlations of 36 genes (31 genes in the sphingolipid metabolic pathway and 5 genes encoding the sphingosine-1-phosphate receptors) between breast cancer patients and healthy controls. It is remarkable to observe that the gene expressions were widely and strongly correlated in healthy controls but in general lost in breast cancer patients. This study suggests that gene pair correlation coefficients could be applied as a systematic and novel method for the diagnosis and prognosis of breast cancer.
Treatment of Locally Advanced Gastric Cancer (LAGC): Back to Lauren’s Classification in Pan–Cancer Analysis Era?
Authors: Zurlo Ina Valeria , Basso Michele , Strippoli Antonia , Calegari Maria Alessandra , Orlandi Armando , Cassano Alessandra , Di Salvatore Mariantonietta , Garufi Giovanna , Bria Emilio , Tortora Giampaolo , Barone Carlo , Pozzo Carmelo
Published: July 2020

Background: Guidelines recommend a perioperative approach in patients with stage II/III gastric cancer, but in real-life many patients receive immediate surgery followed by adjuvant chemotherapy (aCT). Although histologic subtypes may have different response to CT, no study has explored the influence of histotype on the efficacy of perioperative CT (pCT) or aCT. Materials and methods: The objective of the study was to evaluate the impact of clinicopathological features and histology (intestinal or diffuse) on survival according to strategy (pCT vs. aCT). The primary endpoint was overall survival (OS) and the secondary endpoint was event-free survival (EFS). Results: Out of 203 patients affected by LAGC, 83 received pCT and 120 aCT. At multivariate, histology and LVI in pCT cohort and positive resection margin in the aCT influenced both OS and EFS. No difference in EFS and OS was observed in relation to strategy. However, in the intestinal-type of pCT cohort survival outcomes were significantly higher compared to the aCT cohort, whereas in the diffuse-type were significantly worse in patients receiving pCT compared to those receiving aCT. Conclusions: Although retrospective and small-sized, this study suggests that the benefit of pCT might be limited to the intestinal-type. This hypothesis needs to be confirmed in prospective series.
Renal and Cardiovascular Toxicities by New Systemic Treatments for Prostate Cancer
Authors: Saltalamacchia Giuseppe , Frascaroli Mara , Bernardo Antonio , Quaquarini Erica
Published: July 2020

Prostate cancer (PC) is the most common male cancer in Western Countries. In recent years, the treatment of relapsed or metastatic disease had benefited by the introduction of a variety of new different drugs. In consideration of the relative long survival of PC patients, side effects of these drugs must be considered and monitored. In this review, we analyzed the newly developed therapies for PC treatment, describing the mechanism of action, the metabolism and latest clinical trials that led to the approval of these drugs in clinical practice. We then evaluated the cardiovascular and renal side effects from pivotal phase III and II studies and meta-analyses. Cardiovascular side effects are the most frequent, in particular hypertension, while renal toxicity is rarer and not well described in literature. Therefore, there is a need to better define the effects of these therapies, in order to personalize patient treatment on the basis of their comorbidities and preferences, in addition to their symptoms and disease load.
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation
Authors: El-Hindi Khadija , Brachtendorf Sebastian , Hartel Jennifer Christina , Oertel Stephanie , Birod Kerstin , Trautmann Sandra , Thomas Dominique , Ulshöfer Thomas , Weigert Andreas , Utermöhlen Olaf , Krönke Martin , Grösch Sabine
Published: July 2020

Ceramide synthase 5 is one of six enzymes that catalyze the production of ceramides from sphingosine or sphinganine. Ceramides are important components of cell membranes and act as signaling molecules. Previously it has been shown that ceramide synthase 6 and 2 influence colitis in several animal models with sometimes opposite effects. Here, we investigated the disease course of dextran sodium sulfate-induced acute colitis and azoxymethane/dextran sodium sulfate-induced colitis-associated colon cancer in mice with global ceramide synthase 5 knockout (CerS5-ko) or with ceramide synthase 5 knockout restricted to the colon epithelium (CerS5fl/fl VilCre). We monitored disease development and analyzed colon barrier function as well as the immune cell status in these mice. CerS5-ko mice but not CerS5fl/fl-VilCre mice were more susceptible to acute and chronic inflammation. However, the cell barrier function of colon epithelial cells was not disturbed by downregulation of ceramide synthase 5. Instead, untreated CerS5-ko mice displayed reduced numbers of CD3+ immune cells in the spleen, colon, and blood, especially of intraepithelial CD8+ T-cells, which was not obvious in CerS5fl/fl Vil Cre mice. Reduced T-cell number in colon tissue of CerS5-ko mice was accompanied by a reduced expression of IL-1β, IFNγ, and IL-4. In vitro investigations revealed that knockdown of ceramide synthase 5 in T-cells impaired T-cell activation. In summary, we show that CerS5-ko mice were more susceptible to dextran sodium sulfate-induced colitis and azoxymethane/dextran sodium sulfate-induced colitis-associated colon cancer. A reduced number of T-cells in the colon epithelium that was already the case in untreated CerS5-ko mice might have contributed to this effect.
Natural History and Prognostic Factors at First Relapse in Multiple Myeloma
Authors: Wang Chen , Soekojo Cinnie Yentia , Mel Sanjay de , Ooi Melissa , Chen Yunxin , Goh Allan Zhi Kai , Nagarajan Chandramouli , Chng Wee Joo
Published: July 2020

The prognosis of multiple myeloma has considerably improved due to the introduction of novel agents in the upfront setting. However, the great majority of patients ultimately relapse, and choosing a salvage treatment at first relapse remains challenging. The natural history of first relapsed disease in the current era is also not well described. We retrospectively studied 300 patients with first relapsed myeloma seen between 2004 and 2019 from two institutes in Singapore. The median duration from diagnosis to first relapse was 22.7 months (1.1–97.0 months). Most patients received novel agent-based induction therapy, and 41.3% underwent autologous stem cell transplant. A very good partial response (VGPR) or better was achieved in 48.6%. Regarding first relapse, 50.5% were symptomatic and 19.0% received newer agent-containing regimens. Nearly a third of patients (31.7%) had a VGPR or better response. The median progression free and overall survival from first relapse was 12.0 and 44.8 months, respectively. Based on a randomized sample splitting, we first identified non-hyperdiploid karyotype at diagnosis, clinical relapse, and treatment sequence as impacting survival independently from a testing cohort, and we then further demonstrated their significance in a validation cohort. This study provides a real-world picture of first relapsed myeloma and highlights the prognostic importance of the treatment sequence.