bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive optimal sustainability framework in urban water supply system under different runoff scenarios
Authors: Moudi Mahdi
Published: October 2021

Recent droughts have caused a crisis in the water supply procedure, because as available water resources become more limited, the imbalance between the growing water demand and water supply in different sectors leads to unsustainability in the system. Thus, this study proposes a dynamic model to optimize water supply system under different scenarios aimed at improving sustainability of system. In fact, due to the negative impacts of the water crisis, the sustainability of the dynamic water supply system is evaluated and optimized according to the performance indicators of the system. Also, to investigate the proposed model, a real case study of the Sistan basin in Iran over ten years period is conducted. Based on the model, different management insights along with the scenario analysis are considered in order to assess the sustainability of system in more detail. According to the final output, the highest level of sustainability is related to the domestic sector because it has higher reliability and less vulnerability than other sectors.
Molecular Dynamics Simulation of The Influence of the Trans-structure in the Molecular Chain Structure of Natural Rubber On Its Tensile Stress
Authors: Li Zechun , Yang Changjin , Zhao Fuchun , Wei Yanchan , Liao Shuangquan
Published: October 2021

Predicting the influence of trans-structures in the molecular chain structure of natural rubber (NR) on its tensile stress using molecular dynamics (MD) simulations. In this study, establish two all-atom models, all cis-structure model (model-1), containing 2% trans-structure and 98% cis-structure model (model-2), and calculated the cohesive energy density (CED) of the model to determine the feasibility of the model to simulate NR. Then, uniaxial tensile simulations were carried out for both models and it was found that the presence of the inverse structure reduced the tensile stresses in the models. This study is an important theoretical guide to the preparation of high-performance isoprene rubber (IR).
Effects of Virtual Reality-Based Physical And Psychological Exercise On Depression In Stroke Patients : A Meta-Analysis
Authors: Liu Hebing , Cheng Zhaohua , Wang Shuo , Jia Yong , Li Chen
Published: October 2021

Background: Virtual Reality (VR) has been widely used in health-related fields. The aim of this study was to assess the effectiveness of virtual reality-based physical and psychological exercise on depression.Methods: A total of 752 patients with stroke from 11 randomized controlled trial (RCT) studies were included in this meta-analysis and the studies derived from 6 electronic databases searched from database inception to August 2021. For continuous results, the standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated to synthesize the effects.Results: The meta-analysis showed that compared with control group, VR-based interventions significantly decreased the depression scale score (SMD = −0.71, 95% CI: −1.32, −0.10) in the subjects. The results showed that the the patient age and total intervention time had a significant impact on the outcome of depression. The smaller the age and longer the intervention duration, the greater the impact on the outcome of depression.Conclusions: The current meta-analysis indicated the virtual reality-based physical and psychological exercise has a significant effect on depression in stroke patients compared to controls. The study showed an outstanding reduction in depression for aged under 60 participants and intervention longer than 8 weeks. At the same time, clinical studies of different ages and different intervention time also need further in-depth study.
The impact of intrauterine growth restriction (IUGR) on neonatal primary hemostasis
Authors: Kollia Maria , Iacovidou Nicoletta , Iliodromiti Zoe , Pouliakis Abraham , Sokou Rozeta , Mougiou Vasiliki , Boutsikou Maria , Politou Marianna , Boutsikou Theodora , Valsami Serena
Published: October 2021

Platelet function in IUGR neonates remain a field of debate, especially in preterm subgroup. Platelet Function Analyzer (PFA-100) offers a quantitative in vitro assessment of primary, platelet-related hemostasis. Our aim was to examine platelet function using PFA-100 in term and preterm IUGR neonates and associate our results with several perinatal parameters. PFA-100 was applied on 74 IUGR neonates, 48 full-term (> 37 weeks’ gestation) and 26 preterm neonates (< 37 weeks’ gestation). Control group consisted of 118 healthy neonates. Two CTs (with COL/EPI and COL/ADP cartridges) were determined on cord blood samples for each subject. COL/EPI CTs were prolonged in IUGR (median 132s) compared to control neonates (median 112,5s), p=0.0371. Median COL/EPI CT for term and preterm IUGR neonates was 126s and 137s respectively (p=0.0013), and COL/ADP CT was 70s for term and 75s for preterm IUGR neonates (p=0.0827). COL/ADP CTs were shorter in IUGR neonates born via vaginal delivery (p=0.0065), shorter after intrapartum antibiotic prophylaxis with ampicillin (p=0.0045) and prolonged in neonates whose mothers received epidural anesthesia (p=0.032). The cause of IUGR has no impact on CTs (p>0.05 in all cases). COL/EPIand COL/ADP CTs had positive correlation (r=0.37, p<0.0012) whereas no correlation was proved between both CTs and hematological parameters in IUGR neonates. Conclusions: IUGR neonates showed impaired platelet function, with preterm IUGR neonates confronting the greater risk for bleeding tendency. Prolonged COL/EPI CTs seemed to be independent of hematological parameters, especially thrombocytopenia of IUGR neonates.
Banknote Authenticity is Signalled By Rapid Neural Responses
Authors: Dodgson Daniel B. , Raymond Jane E.
Published: October 2021

Authenticating valuable objects is widely assumed to involve protracted scrutiny for detection of reproduction flaws. Yet, accurate authentication of banknotes is possible within one second of viewing, suggesting that rapid neural processes may underpin counterfeit detection. To investigate, we measured event-related brain potentials (ERPs) in response to briefly viewed genuine or forensically recovered counterfeit banknotes presented in a visual oddball counterfeit detection task. Three ERP components, P1, P3, and extended P3, were assessed for each combination of banknote type (genuine, counterfeit) and overt response (“real”, “fake”). P1 amplitude was greater for oddballs, demonstrating that the initial feedforward sweep of visual processing yields the essential information for differentiating genuine from counterfeit. A similar oddball effect was found for P3. The magnitude of this P3 effect was positively correlated with behavioural counterfeit sensitivity, although the corresponding correlation for P1 was not. For the extended P3, amplitude was greatest for correctly detected counterfeits and similarly small for missed counterfeits, incorrectly and correctly categorised genuine banknotes. These results show that authentication of complex stimuli involves a cascade of neural processes that unfolds in under a second, beginning with a very rapid sensory analysis, followed by a later decision stage requiring higher level processing.
Terahertz Plasmonic Quantum Cascade Lasers: A Comprehensive Physics Study
Authors: Pakfetrat Faezeh , Pakarzadeh Hassan
Published: October 2021

Generation of terahertz (THz) radiation has been a hot research topic in recent years. Plasmonic quantum cascade lasers (QCLs) are among the most compact and efficient sources to generate THz radiation. In this paper, we comprehensively study plasmonic QCLs designed based on the antenna-feedback structure to generate efficient radiation about the center frequency of 3 THz. By changing the geometric structure of the plasmonic cavity and using two-dimensional simulation, a minimum loss less than 5.9 cm-1 is achieved at the lasing frequency. It is also possible to control the orientation of the output beam either vertically or tilted by changing the geometry of the antenna design via chirped or non-chirped grating scheme. Moreover, the output characteristics of the QCL are simulated based on the three-level rate equations through which the dynamics of the laser, as well as the P-I curve are investigated. Also, the gain spectra for two laser designs (with chirped and non-chirped gratings) are simulated and compared to each other. The results of this paper may provide deep insight into designing efficient laser sources in the THz region.
Dietary Intake and Socio-economic Predictors of Inadequate Energy and Nutrient Intake Among Women of Child Bearing Age in Karamoja Sub-region of Uganda
Authors: Muggaga Christopher , Uma Ipolto Okello , Kaaya Archileo Natigo , Taylor David , Ongeng Duncan , Mugonola Basil
Published: October 2021

Background: Karamoja sub-region is the most food insecure part of Eastern Africa. The poor status of food security in the sub-region is reflected in the high rate of undernutrition among women of child bearing age (WCBA) and children under five years (CUFY). The sub-region is unique in Uganda in terms of cultural diversity, agro-ecology and rainfall pattern, and agricultural practices. However, the influence of these unique characteristics on dietary intake of WCBA in the sub-region is less understood. Therefore, this study examined dietary intake and socio-economic predictors of inadequate energy and nutrient intake among WCBA in Karamoja sub-region. Methods: A longitudinal study design was used involving 755 WCBA in the harvesting season where 635 were followed-up in the planting season. Data were collected using 24-hour recall, dietary diversity, and socio-economic and demographic questionnaires. Results: Intake of energy and nutrients were generally significantly higher (p<0.05) during the planting season than in the harvesting season. Irrespective of the district, physiological status and season, household consumption of plant-based foods was far higher than intake of animal-based foods dominated by starchy stables (76-100%), dark green leafy vegetables (70-100%) and legumes, nuts and seeds (22-97%) depending on the district. Majority of the respondents had two meals (breakfast: 65-100%; supper: 90-100%) with up to 45% of WCBA who consumed alcohol across meal times. Overall on average, 57.7, 66.6, 78.5, 60.3, 67.7 and 93.7% of WCBA did not meet the Recommended Daily Allowance (RDA) for energy, protein, calcium, iron, zinc and folic acid, respectively. Binary logistic regression revealed that inadequate intake of energy and nutrients significantly increased (p<0.05) with the status of being Lactating/breastfeeding, and was influenced by age of WCBA, number of women married, education level and occupation of the household head depending on season. Conclusions: This study demonstrated that dietary intake of WCBA in Karamoja sub-region was inadequate. Age of WCBA, number of women married, education level and occupation of the household head and spouse, and being a lactating/breastfeeding mother were the key socio-economic and demographic factors that influenced inadequate intake of energy and nutrients among WCBA.
The Effect and Mechanism of Lipoxin A4 on Neutrophil Function in LPS-induced lung injury
Authors: Pan Wenhao , Hu Xin , Chen Ben , Xu Qichao , Mei Hongxia
Published: October 2021

Excessive inflammatory response caused by infiltration of a large number of neutrophils is one of the important features of acute lung injury(ALI)/acute respiratory distress syndrome (ARDS). Lipoxin A4 (LXA4) is an important endogenous mediator in the process of inflammation resolution, which has a strong role in promoting inflammation resolution. In this study, we examined the impact of LXA4 on the pulmonary inflmmatory response and the neutrophil function in a rat model of ARDS. Our results indicated that Exogenous administration of LXA4 could reduce the degree of lung injury in ARDS rats and inhibit the release of pro-inflammatory factors TNF- α and IL-1β in lung tissue homogenate. However, LXA4 has no lung protective effect on ARDS rats with neutrophil depletion in rats, nor can it inhibit the levels of pro-inflammatory factors TNF-α and IL-1β in lung tissue homogenate. LXA4 can inhibit the production of reactive oxygen species (ROS) and NETs in peripheral blood neutrophils of ARDS rats. At the same time, LXA4 can promote the phagocytosis of neutrophils in ARDS rats in vitro, and can also promote the apoptosis of neutrophils in ARDS rats and reduce neutrophil NETosis. In addition, the effect of LXA4 on the function of peripheral blood neutrophils in ARDS rats is mediated by its receptor ALX. LXA4 can inhibit the release of NE and MPO from neutrophils, thereby inhibiting the production of NETs, and the effect of LXA4 can be comparable to NEi and MPO inhibitors. In summary, these findings indicate that LXA4 has a protective effect on LPS-induced ARDS rats by affecting the function of neutrophils.Summary sentenceLXA4 has protective effect on LPS induced ARDS rats by affecting the function of neutrophils.
Energy-Exergy and Cost Analyses of Solar Tower Systems with Various Capacities for Mersin Province
Authors: TURNA DİLSEL Elif , ŞANLI Bengi
Published: October 2021

In present study, technical performance and cost of the solar tower system with the capacities of 10 and 20 MW for Mut district of Mersin were investigated. The solar tower systems with various capacities weredesigned by using SAM (System Advisor Model) program theoretically. For SAM program analysis, TMY3 solar radiation data of Mut district of Mersin located at the coordinates of 33.4° E 36.7° N was used. For the capacities of 10 and 20 MW, the energy generated by this system was determined and the cost of solar tower system was calculated for this system with the capacity of 10 and 20 MW, the number of heliostats was determined as 580 and 1115, respectively and the layout plan of heliostat was generated.
Moreover, the first law and the second law of thermodynamic were applied. Energy and exergy efficiencies were determined.
Yapay Sinir Ağları Yöntemi ile Adıyaman Gölbaşı-Adıyaman Merkez Arasının Heyelan Duyarlılık Değerlendirmesi
Authors: TANRIVERDİ Berna , ORHAN Osman , TEKİN Senem
Published: October 2021

Bu çalışmada, Gölbaşı-Merkez (Adıyaman) arasında kalan yaklaşık 1200 km2’lik bölgede yapay sinir ağları yöntemi ile heyelan duyarlılık değerlendirmesi yapılmıştır. Çalışma alanında 177 heyelan bulunmakta olup, 79,85 km2’lik alana sahiptir. Duyarlılık değerlendirmesi için yükseklik, jeoloji, yamaç eğimi, pürüzlülük, topoğrafik nemlilik indeksi parametreleri heyelan hazırlayıcı faktörler olarak kullanılmıştır. Çalışma alanından elde edilen veri seti rastgele seçim yöntemiyle %80’i analiz, %10’u test ve %10’u doğrulama verisi olmak üzere üçe ayrılmıştır. Elde edilen duyarlılık haritası çok düşük ile çok yüksek arasında 5 sınıfta değerlendirilmiştir. Elde edilen heyelan duyarlılık haritasına göre; çalışma alanının yaklaşık %30’u, mevcut heyelanların ise %78,4’ü yüksek ve çok yüksek duyarlı alanlarda yer almaktadır. Elde edilen heyelan duyarlılık haritasının doğruluğu alıcı işletim karakteristik eğrisi ve eğri altında kalan alan ile değerlendirilmiş olup 0,84 olarak hesaplanmıştır Bu değer kurulan modelin

doğruluğunun yüksek bir değere sahip olduğunu göstermektedir
Yapısal Olarak Değiştirilmiş HMX-DFT Çalışması
Authors: MERT Mehmet Erman
Published: October 2021

Oktahidro-1,3,5,7-tetranitro-1,3,5,7-tetrazosin (HMX) askeri ve endüstriyel uygulamalarda yaygın olarak kullanılan nitramin türevi bir patlayıcıdır. HMX ve benzeri özelliklere sahip patlayıcılar için duyarlılık önemli bir parametredir. Duyarlılığın düşürülmesi sayesinde ısı, sıcaklık, çarpma, sürtünme ile statik elektrik deşarjı gibi çeşitli olayların oluşmasıyla meydana gelebilecek kontrolsüz patlamalar önlenebilir. Bu amaçla, çeşitli katkı maddeleri kullanmak veya patlayıcı etkide önemli bir kayıba neden olmaksızın kimyasal modifikasyonlar yapılmaktadır. HMX(C4H8N8O8) molekülünün 4 tane nitro grubu vardır. Bu çalışmada, nitro gruplarının nitrozo ve amino gruplarına dönüştürülmesiyle duyarlılığı düşürmenin mümkün olabileceği düşünülmektedir. Balistik özellikler, yani patlama hızı (D) ve patlama basıncı (P) Kamlet-Jacobs denklemleri kullanılarak incelenmiştir. Elde edilen sonuçlara göre, belirtilen moleküler modifikasyonlarla, HMX'in duyarlılığının düşürülebileceği tespit edilmiştir.
Generation of Alternating Droplets with Different Viscosities in a Microfluidic Channel
Authors: SAQIB Muhammad , ERDEM Emine Yegan
Published: October 2021

Controlled alternating droplet formation in a microfluidic system can lead to an on-chip droplet-based pattern generation. This enables tracking of different samples individually within the same device. For instance, two different liquids can be segmented in a sequenced, repetitive fashion. In this work, we first show pattern generation by using liquids with unequal viscosities. Droplets of water and glycerol solution are generated in an alternating, repetitive fashion by using a microfluidic system with tapered, double T-junction. We also introduce a microsystem that has a mixing unit that generates a controlled sequence of droplets formed by mixing two different liquids on-chip. We believe that this study can have

applications such as biological analysis, sorting, cell-based monitoring or on-chip chemical synthesis.
Estimation of the Soil Saturated Hydraulic Conductivity and Soil Sorptivity of Terraced Soil Using Four-Term Expansions of the Haverkamp Model
Authors: YILMAZ Deniz
Published: October 2021

Uzunçayır water retention Dam is located in the Tunceli province. This semi-arid mountainous region in eastern Turkey is prone to erosion. To combat this phenomenon, terraces along the edge of the Munzur University campus were built on sloping ground with pine plantations. The objective is twofold, on the one hand to mitigate soil erosion and protect the dam from sediments deposits, and on the other hand to promote the infiltration of rainwater and the vegetation of the sloping soil. However, the so-called ecofunctions of the terraces over the time are not proven. Monitoring the infiltration capacities of the terraces over time and space will allow a better understanding of their contribution to the hydrology of the watershed and their effect on soil erosion. The Beerkan infiltration technique offers simple and inexpensive experimental protocols. In addition, treatment methods are constantly improving. More recently, the four-term expansion of the implicit Haverkamp cumulative infiltration equation has been proposed. This complicated but robust formulation was used in this study to estimate the soil sorptivity S and saturated hydraulic conductivity Ks of terrace soil at Tunceli. The average Ks value of studied site was estimated to be 0.0852 mm/s with a standard deviation of 0.0112 mm/s. The soil sorptivity values were more extensive with mean value of 2.1227 mm/s0.5 and a standard deviation of 0.5855 mm/s0.5. The fit of the model used was perfect, showing that fast and robust estimation of S and Ks are possible using the new model.
Sportcivil szervezetek társadalmi érintettségének vizsgálata
Authors: Tamás Dr. Madarász , Szabados György Norbert
Published: October 2021

A KSH hazai adatbázisában fellelhető információkat elemezve azt tapasztalhatjuk, hogy a klasszikus civil szervezetek, különösen a sportprofillal rendelkező civil szervezetek bevételének meghatározó része főként állami vagy magán támogatásból származik. Emellett az is elmondható, hogy ezek a szervezetek alapvetően nem profit orientáltak, és jelentős szerepet töltenek be a társadalmi integrációban, és lényeges társadalmi feladatok ellátásában. Épp ezért lényeges kérdés, hogy milyen mértékben és módon valósul meg a társadalmi beágyazottságuk, milyen módon hatnak az emberekre a civil szervezetek a működésük során? A civil szervezetek azon belül is a sport civil szervezetek társadalmi hasznosságának vizsgálata, a szféra támogatottsági viszonyai miatt kiemelt területként jelentkezik. Vizsgálatunkban arra vállalkozunk, hogy megvizsgáljuk a felmérésben szereplő szervezetek aktivitását, azok társadalmi hatását és a keletkező adatokat összevessük a helyi társadalomban betöltött szerepükkel. A vizsgálat során felmért civil szervezetek közel 50%-a lokális hatókörrel rendelkezik, valamint több mint 50%-a jellemzően tömeg-és szabadidősporttal kapcsolatos tevékenységet folytat.
Effects of Chilling Duration on Marbling Score of Beef Carcasses
Authors: Hanes Caitlin , Coatney Kalyn B. , Rivera Daniel , Schilling M. Wes , Dinh Thu
Published: October 2021

Two hundred and nine beef carcasses (body weight of 361±53 kg) from crossbred, grain-finished cattle were harvested in a commercial abattoir and subjected to continuous chilling for 96 h at 0°C to 3°C in a commercial hot box with a wind speed of 3.1 m/s and 153 lux of fluorescent light. At 24, 48, 72, and 96 h, the carcasses were analyzed for fatty acid composition,marbling score, pH, shrinkage, color, and aerobic plate count (n = 50). Carcasses reached 3°C after 12 to 16 h of chilling. There were minimal changes in shrinkage among time point (−0.4% to 1.2%; P ≤ 0.002), pH (5.56 to 5.69; P ≤ 0.001), and aerobic plate count (0.1 to 0.7 log; P < 0.001). Initial 24-h grading by a USDA grader revealed a grade composition of 21.1% Slight (n = 44), 34.0% Small (n = 71), 17.2% Modest (n = 37), 17.7% Moderate (n = 36), and 10.1% Slightly Abundant (n = 21). With a marbling score in numeric values between 200 (Practically Devoid00) and 1100 (Abundant00), carcasses that had Small or greater marbling score at 24 h experienced a decrease of 34 to 60 points after 96 h of chilling (P ≤ 0.042). Comparatively, the marbling scores of the Slight carcasses increased from 442 points at 24 h to 469 points at 96 h. Moreover, Slight carcasses had a greater percentage of polyunsaturated fatty acids (P < 0.001). Results indicate that chilling for 96 h increases the marbling score of USDA Select but has minimal impacts on the marbling score of greater USDA quality grades.
Propuesta de Actividades Profesionales Confiables para la especialidad de Geriatría
Authors: Gutiérrez Barreto Samuel Eloy , Durán Pérez Verónica Daniela , Ávia Ávila Arturo , Sosa Tinoco Eduardo , Pacheco Pacheco Jonny , Gutiérrez Robledo Luis Miguel
Published: October 2021

Introducción: La educación basada en competencias ha sido considerada como una propuesta pedagógica en medicina, en las últimas décadas. En los contextos clínicos se han utilizado las Actividades Profesionales a Confiar (APC) para la aplicación de las competencias. El desarrollo de esta estrategia ha sido implementado en diversas especialidades para mejorar la calidad de la formación médica de posgrado.Objetivo: describir el proceso de construcción de APROC para la especialidad de Geriatría.Método: Este estudio utilizó el método mixto secuencial con una fase cualitativa seguida de una fase cuantitativa de validación. En la primera fase, se realizaron entrevistas a profundidad a médicos geriatras. Posteriormente, se realizó una triangulación con otras fuentes para construir las APROC. En la segunda fase, por medio de la técnica Delphi modificada se realizó consenso de expertos con profesores de la especialidad de geriatría.Resultados: Se realizó la propuesta de construcción de una APC y se construyeron diez APC para la formación de médicos geriatras, divididas en cuatro años de formación.Conclusiones: Este es el inicio de una propuesta educativa para profesores y estudiantes de la especialidad de Geriatría en Latinoamérica. Consideramos que es necesaria una adaptación al contexto, una vez que se utilice en la práctica clínica. Se ha de continuar el estudio de su implementación para demostrar los efectos de esta propuesta.
Descripción de biomecánica asociada a disyunción maxilar con anclaje esqueletal: Reporte de caso
Authors: Rojas Bustos Patricio , Córdova Salinas Pedro , Santos Naranjo Geraldine , Vergara Santoro Carolina
Published: October 2021

Introducción: La discrepancia transversal corresponde a una anomalía común en ortodoncia, la cual debe ser corregida tempranamente. Actualmente para su tratamiento existen disyuntores con anclaje dentario, híbrido o esqueletal, los cuales limitarían los efectos adversos que han sido asociados a los disyuntores con anclaje dentario. Dada la falta de evidencia concreta con respecto a los efectos de la disyunción con anclaje esqueletal, es que este reporte de caso profundiza en su biomecánica, determinando cambios dentarios y esqueletales, medidos en imágenes de tomografía computarizada cone-beam (TCCB). Caso clínico: Paciente de sexo masculino, 13 años de edad,  presenta una compresión maxilar de 6 mm. Su tratamiento consistió en un disyuntor tipo BAME (bone-anchored maxillary expander), dispositivo soportado por 4 microtornillos palatales. Se tomaron registros de TCCB, previo (T0) y posterior a la disyunción (T1). Se registraron mediciones transversales a nivel anterior y posterior, modificando el protocolo de medición propuesto por Rojas et al. (1). Se utilizaron puntos de referencias alveolares y dentarios, medidas angulares de inclinación de caninos y primeros molares, y se identificó el estadío de maduración de la sutura medio palatina (SMP), junto con la medición del diastema interincisivo. Discusión: El dispositivo tipo BAME generó un aumento en la dimensión transversal de tipo esqueletal evidenciado en los parámetros transverales alveolares y dentarios en una proporción similar, radiolucidez de la SMP, angulación molar invariable y disminución simétrica en la inclinación canina. Lo anterior demostró una disyunción maxilar paralela sin efectos biológicos adversos.
Robust and Repeatable Biofabrication of Bacteria-Mediated Drug Delivery Systems: Effect of Conjugation Chemistry, Assembly Process Parameters, and Nanoparticle Size
Authors: Zhan Ying , Fergusson Austin , McNally Lacey R. , Davis Richey M. , Behkam Bahareh
Published: October 2021

Bacteria-mediated drug delivery systems comprising nanotherapeutics
conjugated onto bacteria synergistically augment the efficacy of both
therapeutic modalities in cancer therapy. Nanocarriers preserve
therapeutics’ bioavailability and reduce systemic toxicity, while
bacteria selectively colonize the cancerous tissue, impart intrinsic and
immune-mediated antitumor effects, and propel nanotherapeutics
interstitially. The optimal bacteria-nanoparticle (NP) conjugates would
carry the maximal NP load with minimal motility speed hindrance for
effective interstitial distribution. Furthermore, a well-defined and
repeatable NP attachment density distribution is crucial to determining
these biohybrid systems’ efficacious dosage and robust performance.
Herein, we utilized our Nanoscale Bacteria-Enabled Autonomous Delivery
System (NanoBEADS) platform to investigate the effects of assembly
process parameters of mixing method, volume, and duration on NP
attachment density and repeatability. We also evaluated the effect of
linkage chemistry and NP size on NP attachment density, viability,
growth rate, and motility of NanoBEADS. We show that the linkage
chemistry impacts NP attachment density while the self-assembly process
parameters affect the repeatability and, to a lesser extent, attachment
density. Lastly, the attachment density affects NanoBEADS’ growth rate
and motility in an NP size-dependent manner. These findings will
contribute to the development of scalable and repeatable
bacteria-nanoparticle biohybrids for applications in drug delivery and
beyond.

Corresponding author(s) Email: 
behkam@vt.edu
Shining light on multi-drug resistant Candida auris: ultraviolet-C disinfection, wavelength sensitivity, and prevention of biofilm formation of an emerging yeast pathogen
Authors: Mariita Richard , Davis James , Lottridge Michelle , Randive Rajul
Published: October 2021

Background: Candida auris is an emerging fungal pathogen of worldwide
interest. It is associated with high mortality rates and exhibits
increased resistance to antifungals. Ultraviolet-C (UVC) light can be
used to disinfect surfaces to mitigate its spread. In this study, we
analyzed the performance of different UVC wavelengths against C. auris
to determine its wavelength sensitivity and UVC dose requirements and
evaluated biofilm prevention dose requirements on most used materials in
healthcare settings. Objectives: 1. To investigate UVC disinfection
performances and wavelength sensitivity of C. auris; 2. To evaluate the
UVC dose required for prevention of biofilm prevention on stainless
steel. Methods: C. auris was grown following standard procedures. The
study utilized six different UVC LED arrays with wavelengths between 252
and 280 nm. Arrays were set at similar intensities, to obtain doses of
5-40 mJcm-2 and similar irradiation time. Disinfection performance for
each array was determined using log reduction value (LRV) and percentage
reduction by comparing the controls against the irradiated treatments.
Evaluation of the ability of 267 nm UVC LEDs to prevent C. auris biofilm
formation was investigated using stainless steel, plastic coupons, and
poly-cotton fabric. Results: Peak sensitivity to UVC disinfection was
between 267 and 270 nm. With 20 mJcm-2, the study obtained LRV 3. On
steel coupons, 30 mJcm-2 was sufficient to prevent biofilm formation, on
plastic only 10 mJcm-2. A dose of 60 mJcm-2 reduced biofilms on
poly-cotton fabric significantly. Conclusions: Results revealed that C.
auris was most susceptible at 267-270 nm. Additional highlights from the
study allow for the design and implementation of disinfection systems.
Theoretical investigation on the elastic and thermodynamic properties of CuInS2
Authors: Fan Shenghai , Lu Ziai
Published: October 2021

The first-principles method based on the density functional theory is used to investigate the properties of chalcopyrite CuInS2 crystal. The crystal structural parameters are optimized, and the elastic constants and bulk modulus are also calculated, and the results are highly consistent with those in the literature. The stability of the crystal is judged from the Born stability criteria. Based on the quasi-harmonic Debye model, the pressure and temperature dependencies of the bulk modulus, the Debye temperature, the Gr?neisen parameter, and the thermal expansion coefficient are obtained.
The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets
Authors: Wu Wenting , Syed Farooq , Simpson Edward , Lee Chih-Chun , Liu Jing , Chang Garrick , Dong Chuanpeng , Seitz Clayton , Eizirik Decio L. , Mirmira Raghavendra G. , Liu Yunlong , Evans-Molina Carmella
Published: October 2021

Alternative splicing (AS) within the β cell has been
proposed as one potential pathway that may exacerbate autoimmunity and unveil
novel immunogenic epitopes in type 1 diabetes (T1D). We employed a
computational strategy to prioritize pathogenic splicing events in human islets
treated with IL-1β + IFN-γ as an ex vivo model of T1D and coupled this analysis with a k-mer based
approach to predict RNA binding proteins involved in AS. In total, 969 AS events were identified in
cytokine-treated islets, with the
majority (44.8%) involving a skipped exon.
ExonImpact identified 129 events predicted to impact protein structure. AS occurred with high
frequency in MHC Class II-related mRNAs, and targeted qPCR validated reduced inclusion
of Exon5 in the MHC Class II gene HLA-DMB. Single-molecule RNA FISH confirmed increased
HLA-DMB splicing in pancreatic sections from human donors with established T1D
and autoantibody positivity. Serine and Arginine Rich Splicing Factor 2 was
implicated in 37.2% of potentially pathogenic events, including Exon5 exclusion
in HLA-DMB. Together, these data suggest that dynamic control of AS plays
a role in the β cell response to inflammatory signals during T1D evolution.
Frequency of Envoplakin and Type VII Collagen Autoantibodies and Co-occurrence with Other Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls
Authors: Reitermaier René , Skoll Michael , Touzeau-Roemer Veronique , Aichelburg Maximilian C. , Elbe-Bürger Adelheid , Bauer Wolfgang , Rieger Armin , Schuster Christopher
Published: October 2021

Abstract is missing (Short communication)
DEVELOPING VALUE FRAMEWORK OF STUDENT INFORMATION CULTURE IN THE ORGANIZATION OF SECONDARY VOCATIONAL EDUCATION
Authors: BESSARAB STEPAN K.
Published: October 2021

The article focuses on the problem of developing value framework of student information culture in the organization of secondary vocational education. For the first time, the author reveals pedagogical conditions for the efficiency of this process: the stages of experimental work aimed at developing the value framework of student information culture in the organization of secondary vocational education are considered. The analysis performed before and after the experimental study shows positive dynamics within the value framework development of information culture. It is concluded that the presented results of an empirical study indicate the efficiency of experimental work on the value framework of student information culture in the organization of secondary vocational education.
Autoeficácia, habilidades sociais e clima escolar de estudantes do ensino fundamental
Authors: Falcão Amanda Oliveira , Leme Vanessa Barbosa Romera , Morais Gisele Aparecida de
Published: October 2021

O estudo comparou a autoeficácia acadêmica, as habilidades sociais e o clima escolar de estudantes do final do Ensino Fundamental, considerando diferenças por sexo e a influência do histórico de reprovação escolar, a partir da Teoria Social Cognitiva. Participaram 491 alunos (idade de 11 a 16 anos),  selecionados por conveniência, de ambos os sexos, que frequentavam os três últimos anos do Ensino Fundamental de escolas públicas e particulares de uma cidade do Estado de Minas Gerais. Os participantes responderam ao Inventário de Habilidades Sociais para Adolescentes, ao Children’s Self-Efficacy Scale, ao Questionário de Clima Escolar e ao Questionário com informações demográficas. Os resultados indicaram que as meninas apresentaram mais autoeficácia para atividades extracurriculares/lazer e social e mais empatia e assertividade do que os meninos. Os alunos apresentaram mais habilidades  sociais de abordagem social/sexual e perceberam mais o clima escolar acerca do relacionamento entre estudantes. Estudantes com histórico de reprovação escolar tiveram menor autoeficácia e clima escolar positivo. Os dados evidenciaram as influências dos papéis de gênero e da reprovação escolar sobre as relações interpessoais e o desempenho escolar dos estudantes ao final do Ensino Fundamental, destacando a necessidade de se fomentar programas de intervenção com alunos e professores.
Kepraktisan Video Pembelajaran Kalkulus untuk Fisika dalam Proses Belajar Daring pada Masa Pandemi Covid-19
Authors: Hidayat Rahmat , Sundari Putri Dwi , Jhora Fadhila Ulfa , Hidayati Hidayati
Published: October 2021

Corona virus disease (covid-19) has spread all over the world and became a pandemic in short time. Indonesia is one of the countries that affected by covid-19 pandemic. Covid-19 changed everything in various area including education. Online learning became one of the solutions in universities in order to keep learning process going. Unfortunately, policy to apply online learning is facing many difficulties associated with infra-structure, student economic capability and time management. Learning video is presented to overcome difficulties of online learning during covid-19 pandemic in subject of Calculus for Physics. The video presents material supported by sample problem and solution. Practicality of the learning video was examined by collecting student`s responses in aspect of ease of use, learning time efficiency, attractiveness and benefits. Data was analyzed using percentage formula to determine criteria of practicality. The result of the observation revealed that learning video of calculus for physics has a good practicality that represented by score of each aspects of 81,26% for ease of use, 83,53% for learning time efficiency, 79,87% for attractiveness and 81,08% for benefits. Based on this result we conclude that learning video is very useful to assist student in online learning during covid-19 pandemic. Furthermore, learning video could be one of the best choices in learning media to apply digital and remote learning in facing of Industrial Revolution 4.0.
The right to euthanasia in the context of the realization of the right to life
Authors: Nikitenko L.O. , Babyk M.K.
Published: October 2021

The article examines the concept of euthanasia, the main scientific doctrines, which determine the attitude of legal experts to this phenomenon, and the reasons for the theory about the need to establish the right to euthanasia as the form of realization of the right to die in Ukrainian legislation and at the international level.Theproblemofthecontroversy of the concept that recognizes the existence of the fourth generation of human rights to which the right to euthanasia belongs is covered. It is determined that there are some disputes in scientific circles caused by theemergence of a new generation of rights. It is also determined that the new generation of rights is quite debatable, as it destroys the established classification of human rights.The concept of euthanasia is studied, the main distinguishing features between active and passive forms of the implementation of this phenomenon are characterized. It is identified that the majority of disputes about euthanasia legalizing is related to the implementation of its active form. 

Based on the research of scientists’ positions from different fields of science on the possibility of legalizing euthanasia, the two main views have been identified: for legalizing euthanasia and against it.It has been found that the basis for the difference of opinion on this issue is the controversy of the right to euthanasia in the context of the constitutional human right to life.The case-law of the European Court of Human Rights in issues related to euthanasia is analyzed. The comparison of the two decisions of the Court has been made and on this basis the peculiarities of the regulation of this problem in the international arena are clarified.The positive and negative aspects of the implementation of the right to euthanasia are analyzed.The possibility of establishng the right to die at the state and international levels is considered, its contradiction to the right to life, which is enshrined in the Constitution of Ukraine, as well as in the Declaration of Human and Civil Rights, is justified. The emphasis is placed on the need to develop medicine in order to prevent cases that could lead to the use of euthanasia.Taking into consideration the number and importance of negative factors in euthanasia implementation and the general unwillingness of society to legalize such a right, the conclusion that justified the inadvisability of enshrining the right to euthanasia in the legislation of Ukraine has been developed.
Gender equality in labor legal relations: international legal regulation
Authors: Klimenko M.V.
Published: October 2021

The article analyzes international legal documents on gender equality in labor relations, their significance and role. It is noted that the issues of gender equality in employment and dismissal, the right to fair and equal pay for equal work, the creation of favorable working conditions, as well as economic and social guarantees for the successful performance of professional duties remain relevant worldwide. It is noted that extremely important norms, the priority of which is to ensure equal rights of workers, are contained in the UN conventions (on the elimination of racial discrimination, discrimination against women and protection of the rights of migrant workers and their families), ILO conventions and recommendations (on equal pay for men). and women for work of equal value and discrimination in employment and occupation), as well as in the EU directives on equal pay, equal treatment in the workplace, on the application of the principle of equal treatment to men and women engaged in individual employment and employment. activities, on the safety and health of pregnant workers and workers who have recently given birth or are breastfeeding, in the workplace, on childcare leave, on equal treatment of women and men in social security schemes in the workplace).It is concluded that international labor regulation and the development of international standards to ensure equal rights of workers today is one of the priorities of the world community. Defining, consolidating and implementing international uniform and universally binding standards for the equality of employees is an important step towards creating an effective and civilized tool to protect the world’s population and ensure the living conditions of socially secure workers and their families. As the examples of international organizations and the documents adopted by them show, achieving gender equality is one of the key universally recognized priorities in human development. It is international law that makes it possible to understand the essence, content, structure and importance of gender equality as a key component of human rights, the conditions for sustainable development, peace and security on the planet.
Administrative liability for illegal use of the name and signs of belonging to the National Police of Ukraine
Authors: Rozghon O.H.
Published: October 2021

The article is devoted to the coverage of the essence and features of illegal use of the name and signs of belonging to the National Police of Ukraine as a basis for administrative liability. It is established that despite the spread of of-fenses under Article 184-3 of the Code of Ukraine on Administrative Offenses, there is no court decisions in such cases. Thus, large amounts of penalties remain declarative. Possible reasons for the unsatisfactory state of the mechanism of bringing to administrative liability in cases of illegal use of the name and signs of belonging to the National Police of Ukraine have been identified. It was emphasized that the signs of belonging to the National Police of Ukraine include: police symbols, uniforms of police officers, special ranks, departmental awards, a special badge and a police officer’s ID card. Attention is drawn to the fact that the actions of persons who look like police officers, but in fact are not them, can cause a wide public response, because the population may not know who is in front of them. As a result, the forma-tion of a positive image of the police can be significantly damaged. It is concluded that the current situation around the illegal use of the name and signs of belonging to the National Police of Ukraine needs to be corrected.
Itinerario didáctico multidisciplinar en Madrid: validación con maestros en formación
Authors: Martínez-Hernández Carlos , Yubero Claudia , Robles Moral Francisco Javier
Published: October 2021

Este trabajo tiene como objetivo el diseño y validación de un itinerario didáctico en Madrid con estudiantes de un Grado en Educación Primaria, conformado por visitas y actividades relacionadas con los currículos de Ciencias Sociales y Naturales y, en vinculación, las asignaturas universitarias relacionadas con sus didácticas. La validación se establece con un análisis de datos de enfoque mixto mediante un cuestionario al alumnado participante y una puesta en común de aprendizajes. Entre los resultados destacan el alto porcentaje de nuevos conocimientos multidisciplinares adquiridos, la elevada valoración del conjunto del itinerario y sus partes y la eficacia del ejercicio de geografía urbana para comprender la turistificación de los centros urbanos. Se concluye que los itinerarios didácticos como el de esta experiencia pueden contribuir a mejorar sustancialmente la formación docente y permitir una mayor transferencia a la etapa primaria, por lo que su réplica –con ciertas correcciones detalladas– es aconsejable.
Turning Socio-Political Risk to Your Brand’s Advantage
Authors: Fournier Susan , Srinivasan Shuba , Marrinan Patrick
Published: October 2021

Employment practices, civic responsibilities, philanthropy, environmental stewardship, the conduct of corporate executives and employees, the execution of marketing campaigns: All these topics can trigger brand risk events. The challenging branding environment calls for reimagining classic brand marketing through a refreshed and updated social risk management lens. Companies need to assess which socio-economic marketing opportunities can renew brand resonance. This involves not just identifying revenue generating opportunities, but also identifying, cataloging, and tracking SEP risk types in order for managers to understand the new landscape brands must now navigate. Then, they need to implement a framework to manage a brand’s social risks and to take advantage of potential opportunities. Fully embracing this responsibility changes the marketing executive’s role in a significant way: From top line revenue generation to a dual role that includes managing risks as well as returns.
Purpose Beyond Profit: Things That Matter When Millennials Go Job Hunting
Authors: Buder Fabian , Kittinger-Rosanelli Christine
Published: October 2021

In a survey of future leaders, Millennials answered what motivates them in their careers. Having a positive impact on society was the most important measure for career success, followed by working on interesting and fascinating projects. The classical measures of career success such as a high salary, extensive decision-making authority, leading a large team or power over people were reported to be much less important. A significant proportion of the respondents said they decided not to apply for initially interesting job openings or even turned down interesting job offers if an employer did not fit their values. The Leaders of Tomorrow see a need for lasting change that effects all operations and traditional business models. Companies that fail to increase their efforts now may risk “missing the boat” for the future. Those who fail to establish a purpose beyond profit will shrink their talent pool.
Identification of amylase activity from vannamei shrimps’ (Litopenaeus vannamei) digestive tract using size exclusion chromatography method
Authors: HARIYANTI HARIYANTI , RAHMI HANIFAH
Published: October 2021

Vannamei shrimps (Litopenaeus vannamei), also known as white leg shrimps are widely cultivated and consumed by many people. However, most consumers have removed the shrimp’s head which integrates with its digestive tract. The digestive tract of white leg shrimp contains digestive enzymes, including amylase. This study aimed to determine the protein content and amylase activity from Vannamei shrimps’ digestive tract using the size exclusion chromatography method. The protein isolation of size exclusion chromatography was prepared in three steps, namely; centrifugation, precipitation, and dialysis. The protein from the dialysis step was purified by using gel filtration chromatography. Each obtained fraction was determined the protein content and amylase activity by using spectrophotometer UV-Vis method. The results showed that the fraction of 108th had the highest protein content and amylase activity with a value of 0.85 mg/ml and 25.66U/ml respectively. @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536869121 1107305727 33554432 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; mso-ansi-language:IN; mso-fareast-language:IN;}div.WordSection1 {page:WordSection1;}