bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone mineral density in high-level endurance runners: part A—site-specific characteristics
Authors: Herbert A. J. , Williams A. G. , Lockey S. J. , Erskine R. M. , Sale C. , Hennis P. J. , Day S. H. , Stebbings G. K.
Published: September 2021

Purpose

Physical activity, particularly mechanical loading that results in high-peak force and is multi-directional in nature, increases bone mineral density (BMD). In athletes such as endurance runners, this association is more complex due to other factors such as low energy availability and menstrual dysfunction. Moreover, many studies of athletes have used small sample sizes and/or athletes of varying abilities, making it difficult to compare BMD phenotypes between studies.

Method

The primary aim of this study was to compare dual-energy X-ray absorptiometry (DXA) derived bone phenotypes of high-level endurance runners (58 women and 45 men) to non-athletes (60 women and 52 men). Our secondary aim was to examine the influence of menstrual irregularities and sporting activity completed during childhood on these bone phenotypes.

Results

Female runners had higher leg (4%) but not total body or lumbar spine BMD than female non-athletes. Male runners had lower lumbar spine (9%) but similar total and leg BMD compared to male non-athletes, suggesting that high levels of site-specific mechanical loading was advantageous for BMD in females only and a potential presence of reduced energy availability in males. Menstrual status in females and the number of sports completed in childhood in males and females had no influence on bone phenotypes within the runners.

Conclusion

Given the large variability in BMD in runners and non-athletes, other factors such as variation in genetic make-up alongside mechanical loading probably influence BMD across the adult lifespan.
A tale of two gradients: differences between the left and right hemispheres predict semantic cognition
Authors: Gonzalez Alam Tirso Rene del Jesus , Mckeown Brontë L. A. , Gao Zhiyao , Bernhardt Boris , Vos de Wael Reinder , Margulies Daniel S. , Smallwood Jonathan , Jefferies Elizabeth
Published: September 2021

Decomposition of whole-brain functional connectivity patterns reveals a principal gradient that captures the separation of sensorimotor cortex from heteromodal regions in the default mode network (DMN). Functional homotopy is strongest in sensorimotor areas, and weakest in heteromodal cortices, suggesting there may be differences between the left and right hemispheres (LH/RH) in the principal gradient, especially towards its apex. This study characterised hemispheric differences in the position of large-scale cortical networks along the principal gradient, and their functional significance. We collected resting-state fMRI and semantic, working memory and non-verbal reasoning performance in 175 + healthy volunteers. We then extracted the principal gradient of connectivity for each participant, tested which networks showed significant hemispheric differences on the gradient, and regressed participants’ behavioural efficiency in tasks outside the scanner against interhemispheric gradient differences for each network. LH showed a higher overall principal gradient value, consistent with its role in heteromodal semantic cognition. One frontotemporal control subnetwork was linked to individual differences in semantic cognition: when it was nearer heteromodal DMN on the principal gradient in LH, participants showed more efficient semantic retrieval—and this network also showed a strong hemispheric difference in response to semantic demands but not working memory load in a separate study. In contrast, when a dorsal attention subnetwork was closer to the heteromodal end of the principal gradient in RH, participants showed better visual reasoning. Lateralization of function may reflect differences in connectivity between control and heteromodal regions in LH, and attention and visual regions in RH.
Stereological estimations and neurochemical characterization of neurons expressing GABAA and GABAB receptors in the rat pedunculopontine and laterodorsal tegmental nuclei
Authors: Luquin Esther , Paternain Beatriz , Zugasti Inés , Santomá Carmen , Mengual Elisa
Published: September 2021

To better understand GABAergic transmission at two targets of basal ganglia downstream projections, the pedunculopontine (PPN) and laterodorsal (LDT) tegmental nuclei, the anatomical localization of GABAA and GABAB receptors was investigated in both nuclei. Specifically, the total number of neurons expressing the GABAA receptor γ2 subunit (GABAAR γ2) and the GABAB receptor R2 subunit (GABAB R2) in PPN and LDT was estimated using stereological methods, and the neurochemical phenotype of cells expressing each subunit was also determined. The mean number of non-cholinergic cells expressing GABAAR γ2 was 9850 ± 1856 in the PPN and 8285 ± 962 in the LDT, whereas those expressing GABAB R2 were 7310 ± 1970 and 9170 ± 1900 in the PPN and LDT, respectively. In addition, all cholinergic neurons in both nuclei co-expressed GABAAR γ2 and 95–98% of them co-expressed GABAB R2. Triple labeling using in situ hybridization revealed that 77% of GAD67 mRNA-positive cells in the PPT and 49% in the LDT expressed GABAAR γ2, while 90% (PPN) and 65% (LDT) of Vglut2 mRNA-positive cells also expressed GABAAR γ2. In contrast, a similar proportion (~2/3) of glutamatergic and GABAergic cells co-expressed GABAB R2 in both nuclei. The heterogeneous distribution of GABAAR and GABABR among non-cholinergic cells in PPN and LDT may give rise to physiological differences within each neurochemical subpopulation. In addition, the dissimilar proportion of GABAAR γ2-expressing glutamatergic and GABAergic neurons in the PPN and LDT may contribute to some of the functional differences found between the two nuclei.
The prevalence of homologous recombination deficiency (HRD) in various solid tumors and the role of HRD as a single biomarker to immune checkpoint inhibitors
Authors: Kim Hana , Ahn Soomin , Kim Hongsik , Hong Jung Yong , Lee Jeeyun , Park Se Hoon , Park Joon Oh , Park Young Suk , Lim Ho Yeong , Kang Won Ki , Kim Kyoung-Mee , Kim Seung Tae
Published: September 2021

Purpose

Homologous recombination deficiency (HRD) is related to tumorigenesis. Currently, the possibility of HRD as a prognostic biomarker to immune checkpoint inhibitors is unknown. We aimed to investigate whether HRD has potential as a biomarker for immunotherapy.

Methods

The status of homologous recombination deficiency (HRD) was assessed with the next-generation sequencing (NGS) TruSight™ Oncology 500 assay in 501 patients with advanced solid tumor including gastrointestinal (GI), genitourinary (GU), or rare cancer. Results: among the 501 patients, HRD was observed as follows: 74.7% (347/501) patients; GU cancer (92.0%, 23 of 25), colorectal cancer (CRC) (86.1%, 130 of 151), hepatocellular carcinoma (HCC) (83.3%, 10 of 12), pancreatic cancer (PC) (76.2%, 32 of 42), biliary tract cancer (BTC) (75.0%, 36 of 48), sarcoma (65.0%, 39 of 60), melanoma (52.4%, 11 of 21), other GI cancers (50.0%, 11 of 22), and rare cancer (50.0%, 2 of 4). Sixty-five of the 501 patients had received immune checkpoint inhibitors (ICIs) during the course of the disease. Tumor types of 65 patients treated with ICIs are as follows: melanoma (95.2%, 20 of 21), HCC (33.3%, 4 of 12), rare cancer (25.0%, 1 of 4), GC (12.2%, 14 of 116), BTC (10.4%, 5 of 48), and sarcoma (5.0%, 3 of 60). The most frequently reported mutations were BRCA2 (n = 90), ARID1A (n = 77), ATM (n = 71), BARD1 (n = 67). Patients without HRD exhibited an objective response rate (ORR) of 33.3% (4 of 12), and patients with HRD exhibited an ORR of 34.0% (18 of 53). There was no significant difference in ORR between patients with and without HRD (P = 0.967). Progression-free survival (PFS) was 6.5 months (95% CI 0.000–16.175) in patients without HRD and 4.1 months (95% CI 2.062–6.138) in patients with HRD, revealing no statistical significance (P = 0.441).

Conclusion

Herein, we reported the status of HRD using a cancer-panel for various solid tumor patients in routine clinical practice and demonstrated that HRD as a single biomarker was not sufficient to predict efficacy of ICIs in solid tumor patients.
Locally adaptive change-point detection (LACPD) with applications to environmental changes
Authors: Moradi Mehdi , Montesino-SanMartin Manuel , Ugarte M. Dolores , Militino Ana F.
Published: September 2021

We propose an adaptive-sliding-window approach (LACPD) for the problem of change-point detection in a set of time-ordered observations. The proposed method is combined with sub-sampling techniques to compensate for the lack of enough data near the time series’ tails. Through a simulation study, we analyse its behaviour in the presence of an early/middle/late change-point in the mean, and compare its performance with some of the frequently used and recently developed change-point detection methods in terms of power, type I error probability, area under the ROC curves (AUC), absolute bias, variance, and root-mean-square error (RMSE). We conclude that LACPD outperforms other methods by maintaining a low type I error probability. Unlike some other methods, the performance of LACPD does not depend on the time index of change-points, and it generally has lower bias than other alternative methods. Moreover, in terms of variance and RMSE, it outperforms other methods when change-points are close to the time series’ tails, whereas it shows a similar (sometimes slightly poorer) performance as other methods when change-points are close to the middle of time series. Finally, we apply our proposal to two sets of real data: the well-known example of annual flow of the Nile river in Awsan, Egypt, from 1871 to 1970, and a novel remote sensing data application consisting of a 34-year time-series of satellite images of the Normalised Difference Vegetation Index in Wadi As-Sirham valley, Saudi Arabia, from 1986 to 2019. We conclude that LACPD shows a good performance in detecting the presence of a change as well as the time and magnitude of change in real conditions.
Free flexural vibrations of homogeneous beams with symmetrically variable depths
Authors: Magnucki Krzysztof , Magnucka-Blandzi Ewa , Milecki Szymon , Goliwąs Damian , Wittenbeck Leszek
Published: September 2021

The subject of the paper are homogeneous beams of symmetrically variable depth and bisymmetrical cross sections. Free flexural vibrations of these beams are analytically and numerically studied. Based on Hamilton’s principle, the differential equations of motion of these beams are obtained. The equations of motion are analytically solved with consideration of the bending lines of these beams subjected to their own weight. The fundamental natural frequency for exemplary beams is derived and presented in Tables and Figures.
Longitudinal changes in quality of life and psychosocial problems of primary school children in a deprived urban neighborhood over the course of a school-based integrated approach
Authors: Elsenburg L. K. , Galenkamp H. , Abrahamse M. E. , Harting J.
Published: September 2021

The municipality of Amsterdam implemented a 2-year school-based integrated approach in schools in a deprived neighborhood. The integrated approach targeted the domains of education, health and poverty and the children’s school, neighborhood and home environment by involving various agencies and actors. In this study, changes in children’s quality of life and psychosocial problems over the course of the integrated approach were examined and evaluated. A dynamic cohort design was used. At five measurement occasions (T1–T5) during 2 years, children from four consecutive grades in five schools filled out a questionnaire (total n = 614). In children between 7 and 13 years, quality of life was measured with the KIDSCREEN-10. In children between 9 and 13 years, psychosocial problems were measured with the Strengths and Difficulties Questionnaire. Generalized estimating equations were applied. Time, sex, age, socio-economic status, ethnic background, grade, and school were included as independent variables. Quality of life was higher from the first follow-up during the approach (T2) until the end of the approach (T4) compared to at the start of the approach (T1). At T5, several months after the approach ended, scores returned back to baseline. Likewise, a reduction in children’s psychosocial problems was detected at the end of the approach (T4) compared to at the start of the approach (T1). However, both before and after that time point, no improvements were detected. This study shows that integrated approaches can be beneficial for children’s quality of life and psychosocial health, but continued investments may be needed to maintain established improvements.

Trial registration NTR6571 (NL6395), August 4 2017 retrospectively registered.
Association between age of first exposure and heavy internet use in a representative sample of 317,443 adolescents from 52 countries
Authors: López-Bueno Rubén , Koyanagi Ai , López-Sánchez Guillermo Felipe , Firth Joseph , Smith Lee
Published: September 2021

Internet usage among adolescents has increased substantially over the last years, concurrently with emerging concerns that an abusive use is associated with detrimental health outcomes. Our objective was to examine the association between age of first exposure and heavy Internet usage in different domains. Data from the 2018 wave of the Programme for International Student Assessment (PISA) were retrieved. This included a total of 317,443 participants (49.2% boys) aged 15 and 16 years from 52 countries. Data from both Internet use and age of first exposure were retrieved and used to conduct metanalyses with random effects. Adolescents reporting an age of first exposure of Internet usage at ≥ 13 years old had the lowest odds for heavy Internet use (> 2 h/day) (reference group: ≤ 9 years) during weekends (odds ratio, 0.41 [95% CI, 0.35–0.48]), weekdays (odds ratio, 0.45 [95% CI, 0.37–0.56]), and during school time (odds ratio (odds ratio, 0.86 [95% CI, 0.77–0.96]) even when adjusted for sex, socioeconomic status, and country. A stronger association was observed in adolescents from South and Central America and Eastern Mediterranean regions in the domain of weekends and weekdays. The results indicate that early internet exposure is associated with heavy Internet use, particularly during weekends and weekdays, regardless the geographical region, in a linear fashion. Further research should aim to examine if better education and parental control in specific areas may avoid excessive Internet use that possibly have a negative influence on both mental and physical health.
Positive Effects of Legumes on Soil Organic Carbon Stocks Disappear at High Legume Proportions Across Natural Grasslands in the Pyrenees
Authors: Rodríguez Antonio , Canals Rosa Maria , Sebastià M.-Teresa
Published: September 2021

Soil is the largest terrestrial carbon pool, making it crucial for climate change mitigation. Soil organic carbon (SOC) is suggested to depend on biodiversity components, but much evidence comes from diversity-function experiments. To disentangle the relationships of plant guild diversity with SOC storage (kg m−2) at broad spatial scales, we applied diversity-interaction models to a regional grassland database (n = 96) including wide environmental conditions and management regimes. The questions were: (1) Are the effects of plant guilds on SOC stocks in natural grasslands consistent with those found in experimental systems? (2) Are plant guild effects on SOC stocks independent of each other or do they show interactive—synergistic or antagonistic—effects? (3) Do environmental variables, including abiotic and management, modify guild effects on SOC stocks? Among our most novel results we found, legume effects on grassland SOC vary depending on legume proportion consistently across broad spatial scales. SOC increased with legume proportion up to 7–17%, then decreased. Additionally, these effects were strengthened when grasses and forbs were codominant. Grazing intensity modulated grass proportion effects on SOC, being maximum at relatively high intensities. Interpreting our results in terms of existing contrasted ecological theories, we confirmed at broad spatial scales and under wide-ranging environmental conditions the positive effects of plant guild diversity on SOC, and we showed how legumes exert a keystone effect on SOC in natural grasslands, probably related to their ability to fix inorganic N. Niche complementarity effects were illustrated when codominance of forbs and grasses at optimum legume proportions boosted SOC storage, whereas grass dominance increased SOC stocks at medium–high grazing intensities. These findings can facilitate the preparation of regional and local strategies to ameliorate the soil capacity to absorb carbon.
TRFH: towards real-time face detection and head pose estimation
Authors: Chen Shicun , Zhang Yong , Yin Baocai , Wang Boyue
Published: September 2021

Nowadays, face detection and head pose estimation have a lot of application such as face recognition, aiding in gaze estimation and modeling attention. For these two tasks, it is usually to design two different models. However, the head pose estimation model often depends on the region of interest (ROI) detected in advance, which means that a serial face detector is needed. Even the lightest face detector will slow down the whole forward inference time and cannot achieve real-time performance when detecting the head pose of multiple people. We can see that both face detection and head pose estimation need face features, so a shared face feature map can be used between them. In this paper, a multi-task learning model is proposed that can solve both problems simultaneously. We directly detect the location of the center point of the bounding box of face; at this location, we calculate the size of the bounding box of face and the head attitude. We evaluate our model’s performance on the AFLW. The proposed model has great competitiveness with the multi-stage face attribute analysis model, and our model can achieve real-time performance.
Spontaneous spondylodiscitis and endocarditis: interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm
Authors: Viezens Lennart , Dreimann Marc , Strahl André , Heuer Annika , Koepke Leon-Gordian , Bay Benjamin , Waldeyer Christoph , Stangenberg Martin
Published: September 2021

Previously, the simultaneous presence of endocarditis (IE) has been reported in 3–30% of spondylodiscitis cases. The specific implications on therapy and outcome of a simultaneous presence of both diseases are not yet fully evaluated. Therefore, the aim of this study was to investigate the influence of a simultaneously present endocarditis on the course of therapy and outcome of spondylodiscitis. A prospective database analysis of 328 patients diagnosed with spontaneous spondylodiscitis (S) using statistical analysis with propensity score matching was conducted. Thirty-six patients (11.0%) were diagnosed with concurrent endocarditis (SIE) by means of transoesophageal echocardiography. In our cohort, the average age was 65.82 ± 4.12 years and 64.9% of patients were male. The incidence of prior cardiac or renal disease was significantly higher in the SIE group (coronary heart disease SIE n = 13/36 vs. S n = 57/292, p < 0.05 and chronic heart failure n = 11/36 vs. S n = 41/292, p < 0.05, chronic renal failure SIE n = 14/36 vs. S n = 55/292, p < 0.05). Complex interdisciplinary coordination and diagnostics lead to a significant delay in surgical intervention (S = 4.5 ± 4.5 days vs. SIE = 8.9 ± 9.5 days, p < 0.05). Mortality did not show statistically significant differences: S (13.4%) and SIE (19.1%). Time to diagnosis and treatment is a key to efficient treatment and patient safety. In order to counteract delayed therapy, we developed a novel therapy algorithm based on the analysis of treatment processes of the SIE group. We propose a clear therapy pathway to avoid frequently observed pitfalls and delays in diagnosis to improve patient care and outcome.
Conflict-Driven Satisfiability for Theory Combination: Lemmas, Modules, and Proofs
Authors: Bonacina Maria Paola , Graham-Lengrand Stéphane , Shankar Natarajan
Published: September 2021

Search-based satisfiability procedures try to build a model of the input formula by simultaneously proposing candidate models and deriving new formulae implied by the input.Conflict-drivenprocedures perform non-trivial inferences only when resolving conflicts between formulæ and assignments representing the candidate model. CDSAT (Conflict-Driven SATisfiability) is a method for conflict-driven reasoning inunions of theories. It combines inference systems for individual theories astheory moduleswithin a solver for the union of the theories. This article augments CDSAT with a more generallemma learningcapability and withproof generation. Furthermore, theory modules for several theories of practical interest are shown to fulfill the requirements forcompletenessandterminationof CDSAT. Proof generation is accomplished by aproof-carryingversion of the CDSAT transition system that producesproof objectsin memory accommodating multiple proof formats. Alternatively, one can apply to CDSAT theLCF approach to proofsfrom interactive theorem proving, by defining a kernel of reasoning primitives that guarantees the correctness by construction of CDSAT proofs.
An Energy Conservative hp-method for Liouville’s Equation of Geometrical Optics
Authors: van Gestel R. A. M. , Anthonissen M. J. H. , Boonkkamp J. H. M. ten Thije , IJzerman W. L.
Published: September 2021

Liouville’s equation on phase space in geometrical optics describes the evolution of an energy distribution through an optical system, which is discontinuous across optical interfaces. The discontinuous Galerkin spectral element method is conservative and can achieve higher order of convergence locally, making it a suitable method for this equation. When dealing with optical interfaces in phase space, non-local boundary conditions arise. Besides being a difficulty in itself, these non-local boundary conditions must also satisfy energy conservation constraints. To this end, we introduce an energy conservative treatment of optical interfaces. Numerical experiments are performed to prove that the method obeys energy conservation. Furthermore, the method is compared to the industry standard ray tracing. The numerical experiments show that the discontinuous Galerkin spectral element method outperforms ray tracing by reducing the computation time by up to three orders of magnitude for an error of $$10^{-6}$$

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Effect of Particle Size on Magnetic Phase Coexistence in Nanocrystalline La0.4Bi0.3Sr0.3MnO3
Authors: Souza Anita D. , Rayaprol Sudhindra , Murari M. S. , Daivajna Mamatha D.
Published: September 2021

Magnetic phase coexistence in the substituted perovskite compound, La0.4Bi0.3Sr0.3MnO3, is attributed to the spontaneous moment and a step-like metamagnetic transition observed in the magnetization measurements in its magnetically order state. The magnetism of samples reduced to nanometer sizes by the “top down” approach exhibits interesting changes with respect to the bulk, thus giving a handle in influencing the physical properties by reducing the particle size. The bulk sample orders ferromagnetically at TC = 295 K, whereas in nano-sized samples with particle sizes in the range of 21–30 nm, even though TC does not change, the transitions are suppressed. The nano-sized powder samples show a broad hump in the plot of magnetic susceptibility, signifying the possible disordered antiferromagnetic state. A systematic decrease in the magnitude of magnetization in nano-sized samples shows that the reduction in magnetic interaction could be attributed to the formation of a magnetic dead layer around the magnetic core.
A Consistent BGK Model with Velocity-Dependent Collision Frequency for Gas Mixtures
Authors: Haack J. , Hauck C. , Klingenberg C. , Pirner M. , Warnecke S.
Published: September 2021

We derive a multi-species BGK model with velocity-dependent collision frequency for a non-reactive, multi-component gas mixture. The model is derived by minimizing a weighted entropy under the constraint that the number of particles of each species, total momentum, and total energy are conserved. We prove that this minimization problem admits a unique solution for very general collision frequencies. Moreover, we prove that the model satisfies an H-Theorem and characterize the form of equilibrium.
Effects of knowledge spillovers between competitors on patent quality: what patent citations reveal about a global duopoly
Authors: Acosta Manuel , Coronado Daniel , Ferrándiz Esther , Jiménez Manuel
Published: September 2021

This paper analyses the effects on patent quality of a type of spillovers arising from the disclosure of patent information by firms engaged in competition in a global duopoly. Both firms are involved in producing new technologies and they do not cooperate on joint patents. In this context, we explored whether the disclosure of crucial knowledge in the patents of one of the firms affects the patent quality of its respective competitor. The empirical methodology relies on forward citations as an indicator of quality, and backward citations to the competitor as a measure of spillovers. We estimated several count models with a sample of 7750 patent families (divided into subsamples) owned by two large companies, Airbus and Boeing. Our econometric findings show that, for technologies in which the two firms account for the majority of the global patents, neither of the firms in the duopoly was able to harness spillovers from the rival to improve the quality of its patents. However, knowledge from the competitor becomes relevant, at least for one of the focal firms, in explaining patent quality of other technologies in which the two firms do not exert a dominant position.
Students as scientists’ co-pilots at the onset of technology transfer: a two-way learning process
Authors: Giones Ferran , Kleine Kari , Tegtmeier Silke
Published: September 2021

To provide further knowledge and technology transfer to society, universities are exploring new collaborative models. These new models are regarded as promising alternatives to the patent-centric linear model. However, their implementation requires revising the roles of the actors in the technology transfer process and their relationships. While collaborative models could indeed be an attractive option for universities, there is limited evidence on how these collaboration processes could be effectively introduced. We use a longitudinal embedded multiple case study to explore the contribution of knowledge interactions between scientists and students in the preliminary steps of the technology transfer process. We investigate the learning dynamics between the focal actor, i.e., the scientist, and the students in a university setting to decipher how the introduction of such collaborative processes can contribute to knowledge and technology transfer. Our results suggest that students enrolled in an educational program can contribute to the scientist’s interest and engagement in technology transfer. However, we find out that the extent of the students’ contribution depends on the shared consensus over the technology function and the openness of the scientist to reconsider the technology’s meaning. We contribute to the ongoing exploration of alternative models for technology transfer and the identification of additional roles that students can take in entrepreneurial university ecosystems.
Phase diagram studies for the growth of (Mg,Zr):SrGa12O19 crystals
Authors: Klimm Detlef , Szczefanowicz Bartosz , Wolff Nora , Bickermann Matthias
Published: September 2021

By differential thermal analysis, a concentration field suitable for the growth of Zr, Mg co-doped strontium hexagallate crystals was observed that corresponds well with known experimental results. It was shown that the melting point of doped crystal is ca. 60 K higher than that of undoped crystals. This higher melting points indicate hexagallate phase stabilization by Zr, Mg co-doping and increase the growth window of (Mg,Zr):SrGa12O19, compared to undoped SrGa12O19 that grows from SrO–Ga2O3 melts.
Classification of topological invariants related to corner states
Authors: Hayashi Shin
Published: September 2021

We discuss some bulk-surface gapped Hamiltonians on a lattice with corners and propose a periodic table for topological invariants related to corner states aimed at studies of higher-order topological insulators. Our table is based on four things: (1) the definition of topological invariants, (2) a proof of their relation with corner states, (3) computations of K-groups and (4) a construction of explicit examples.
Virtual Reconstruction System of Building Spatial Structure Based on Laser 3D Scanning under Multivariate Big Data Fusion
Authors: Liang Yuan , Woźniak Marcin
Published: September 2021

Abstract

Existing systems have disadvantages such as slow running speed, long time-consuming, and poor rendering effect in virtual reconstruction of architectural spatial structure. In order to solve such problems, virtual reconstruction system of building space structure is designed using laser 3D scanning technology under condition of fusion of multiple big data. The system was equipped with a 3D laser scanner and connected to computer, and the noise interference was reduced by image preprocessing module to complete the hardware design. The system improved user interface and maintenance module. Eventually, 3D model reconstruction was realized via data acquisition, data registration, coordinate transformation and 3D rendering. The results show that the system designed in this paper runs fast, and color of reconstruction results is consistent, which indicates that reconstruction results of building space structure obtained by the system are conducive to in-depth study of building space.
Man of the Theatre: Stage Performances of T. S. Eliot’s Work in Spain (1949–2016)
Authors: Llorens-Cubedo Dídac
Published: September 2021

T. S. Eliot’s presence in Spanish theatres has taken various forms. His verse drama enjoyed a relative popularity in the late 1940s and in the 1950s: Murder in the Cathedral, The Family Reunion and The Cocktail Party were staged by student and amateur groups, “chamber” companies and even a national theatre. Reviews were ambivalent, most of them finding fault with the plays’ poetic density as an impediment for performance. Although, as a conservative Anglo-Catholic, Eliot was a priori an unproblematic author for the Francoist establishment and its censorship, critics loyal to Spanish National Catholicism were uncomfortable with the tragic fatalism of The Family Reunion, or with the non-judgemental treatment of adultery in The Cocktail Party. When Eliot’s plays were losing their appeal from the late 1950s onwards, only Murder in the Cathedral was occasionally performed in Spain. More recently, intermedial transpositions and dramatizations of Eliot’s poetry have consolidated his image as a great influential poet whose drama is a rarity.
“Un estado de la conciencia contemporánea”: género y moral en La sirena negra de Emilia Pardo Bazán
Authors: Bardavío Estevan Susana
Published: September 2021

Despite Emilia Pardo Bazán’s prominent feminism,La sirena negrahas been strangely overlooked by gender studies. When the novel was published in 1908, Gómez de Baquero judged it “non feminist” due to its superficial heroines and the centrality of its complex masculine characters. Academic studies ofLa sirena negrahave not refuted this idea, since they have elided gender approaches to focus on its decadent aesthetics. This article argues, on the contrary, that the novel’s androcentrism can be read as a Pardo Bazan’s strategy to appropriate the patriarchal discourse and hold it responsible for national degeneration. Emilia Pardo Bazán was harshly affected by the fin-de-siècle crisis. In her opinion, Spanish decay came from a lack of solid morality. Thus, Catholic principles should be restored because they would provide the autoregulation mechanisms to regenerate and reassemble the country. Literature should show the new reality, and the Frenchroman psychologiqueprovided her with an appropriate model.La sirena negrasets out the problem of the moral anomie through its protagonist, Gaspar de Montenegro. The analysis of his sexuality and gender performance reveals the danger of this amoral behavior for the degeneration of society, attributed ultimately to the patriarchal order and the androcentric discourse.
Blaming friends
Authors: Scholten Matthé
Published: September 2021

The aim of this paper is to shed light on the complex relations between friendship and blame. In the first part, I show that to be friends is to have certain evaluative, emotional and behavioral dispositions toward each other, and distinguish between two kinds of norms of friendship, namely friendship-based obligations and friendship-constituting rules. Friendship-based obligations tag actions of friends as obligatory, permissible or wrong, whereas friendship-constituting rules specify conditions that, if met, make it so that two persons stand in a particular type of relationship defined by various friendship-based obligations. I argue that whereas friendship-based obligations apply to actions under direct voluntary control, friendship-constituting rules apply to emotional and evaluative attitudes. The second part develops an account of friendship blame by comparing Scanlon’s account of blame with Wallace’s Strawsonian account of blame. I demonstrate that Scanlon’s account picks out responses that become appropriate when friends’ attitudes are not in agreement with friendship-constituting rules, whereas Wallace’s account picks out responses that become appropriate when friends violate friendship-based obligations. Arguing that the responses picked out by Scanlon’s account do not amount to blame, I show that, when combined, the views give an illuminating picture of possible reactions to friends who fall short of the standards of friendship.
In situ laser manipulation of root tissues in transparent soil
Authors: Ge Sisi , Dupuy Lionel X. , MacDonald Michael P.
Published: September 2021

Aims

Laser micromanipulation such as dissection or optical trapping enables remote physical modification of the activity of tissues, cells and organelles. To date, applications of laser manipulation to plant roots grown in soil have been limited. Here, we show laser manipulation can be applied in situ when plant roots are grown in transparent soil.

Methods

We have developed a Q-switched laser manipulation and imaging instrument to perform controlled dissection of roots and to study light-induced root growth responses. We performed a detailed characterisation of the properties of the cutting beams through the soil, studying dissection and optical ablation. Furthermore, we also studied the use of low light doses to control the root elongation rate of lettuce seedlings (Lactuca sativa) in air, agar, gel and transparent soil.

Results

We show that whilst soil inhomogeneities affect the thickness and circularity of the beam, those distortions are not inherently limiting. The ability to induce changes in root elongation or complete dissection of microscopic regions of the root is robust to substrate heterogeneity and microscopy set up and is maintained following the limited distortions induced by the transparent soil environment.

Conclusions

Our findings show that controlled in situ laser dissection of root tissues is possible with a simple and low-cost optical set-up. We also show that, in the absence of dissection, a reduced laser light power density can provide reversible control of root growth, achieving a precise “point and shoot” method for root manipulation.
Seasonal variation in AMF colonisation, soil and plant nutrient content in gypsum specialist and generalist species growing in P-poor soils
Authors: Cera Andreu , Duplat Estephania , Montserrat-Martí Gabriel , Gómez-Bolea Antonio , Rodríguez-Echeverría Susana , Palacio Sara
Published: September 2021

Aims

Gypsum soils are P-limited atypical soils that harbour a rich endemic flora. These singular soils are usually found in drylands, where plant activity and soil nutrient availability are seasonal. No previous studies have analysed the seasonality of P nutrition and its interaction with the arbuscular mycorrhiza fungi (AMF) colonisation in gypsum plants. Our aim was to evaluate the seasonal changes in plant nutrient status, AMF colonisation and rhizospheric soil nutrient availability in gypsum specialist and generalist species.

Methods

We evaluated seasonal variation in the proportion of root length colonised by AMF structures (hyphae, vesicules and arbuscules), plant nutrient status (leaf C, N and P and fine root C and N) and rhizospheric soil content (P, organic matter, nitrate and ammonium) of three gypsum specialists and two generalists throughout a year.

Results

All species showed arbuscules within roots, including species ofCaryophyllaceaeandBrassicaceae. Root colonisation by arbuscules (AC) was higher in spring than in other seasons, when plants showed high leaf P-requirements. Higher AC was decoupled from inorganic N and P availability in rhizospheric soil, and foliar nutrient content. Generalists showed higher AC than specialists, but only in spring.

Conclusions

Seasonality was found in AMF colonisation, rhizospheric soil content and plant nutrient status. The mutualism between plants and AMF was highest in spring, when P-requirements are higher for plants, especially in generalists. However, AMF decoupled from plant demands in autumn, when nutrient availability increases in rhizospheric soil.
Precision agriculture technology adoption: a qualitative study of small-scale commercial “family farms” located in the North China Plain
Authors: Kendall Helen , Clark Beth , Li Wenjing , Jin Shan , Jones Glyn. D. , Chen Jing , Taylor James , Li Zhenhong , Frewer Lynn. J.
Published: September 2021

Precision agriculture (PA) technologies offer a potential solution to food security and environmental challenges but, will only be successful if adopted by farmers. Adoption in China lags behind that in some developed agricultural economies despite scientifically proven benefits of PA technologies for Chinese agriculture. Adoption is dependent on farmer attitudes and perceptions towards PA technologies. An exploratory qualitative study using in-depth interviews was conducted with Chinese arable farmers (n = 27) to explore their perceptions towards and adoption intentions of PA technologies in two Chinese provinces (Hebei and Shandong). A thematic analysis revealed five central themes to have emerged from the data, these were: “socio-political landscape”, “farming culture”, “agricultural challenges”, “adoption intentions (barriers/facilitators” and “practical support mechanisms”. All were likely to influence the level and rate of adoption of PA technologies amongst family farmers in China. The research revealed an openness to the potential of PA technologies amongst family farmers, although there was heterogeneity in the perceptions of PA technology and willingness to adopt. Improved rates of adoption will be achieved by reducing the barriers to adoption, including the need for low-cost PA applications that can be applied at small scale, improved information provision, financial support mechanisms including more accessible subsidies and credit, and reliable, regulated and affordable service provision.
The abc of the b and c in Spanish: inconsistent and context dependent letter errors and the development of orthographic knowledge in primary school children
Authors: Rodriguez Nuria , Acha Joana
Published: September 2021

This study presents the results of a cross-sectional reading and spelling assessment conducted among 118 Spanish children in 3rd, 4th and 5th grade. The first aim was to explore whether children´s use of orthographic knowledge was modulated by lexical variables—word frequency and orthographic neighborhood—or sublexical variables—context-dependent, inconsistent or neutral letters- as well as the developmental pathway of such knowledge in both tasks. The second aim was to provide insight into the type of errors committed by children in order to detect the words and structures that convey most difficulties. Data showed that children rely on sublexical processes more than on lexical ones in reading and writing. Persistent errors in context-dependent and inconsistent letters were evident even in 5th grade, and writing involved greater difficulty in all grades. The presence of other type of errors such as substitutions, omissions or lexicalizations was negligible. Finally, an item analysis revealed that errors were located in low-frequency syllables, particularly in the first position. Data point to specific and persistent difficulties in context-dependent and inconsistent letters that may hinder the consolidation of accurate orthographic word representations in Spanish.
Security token offerings
Authors: Lambert Thomas , Liebau Daniel , Roosenboom Peter
Published: September 2021

This paper posits that distinguishing security token offerings (STOs) from initial coin offerings (ICOs) is important for the study of entrepreneurial finance. We first provide a working definition of a security token and present an overview of the STO market using a unique STO sample. The STO activity developed after the end of the ICO market bubble. The STO market is, however, still a nascent market. STOs are geographically dispersed but concentrated in jurisdictions with accommodating securities laws. Next, we explore STO success factors. We show that various issuer and offering characteristics traditionally used in the ICO literature also matter for STO success. We also find that success is associated with good governance practices, consistent with the corporate finance literature. We conclude by discussing the implications of native digital securities, the next generation of security tokens, for entrepreneurial finance.
Economic effects of the COVID-19 pandemic on entrepreneurship and small businesses
Authors: Belitski Maksim , Guenther Christina , Kritikos Alexander S. , Thurik Roy
Published: September 2021

The existential threat to small businesses, based on their crucial role in the economy, is behind the plethora of scholarly studies in 2020, the first year of the COVID-19 pandemic. Examining the 15 contributions of the special issue on the “Economic effects of the COVID-19 pandemic on entrepreneurship and small businesses,” the paper comprises four parts: a systematic review of the literature on the effect on entrepreneurship and small businesses; a discussion of four literature strands based on this review; an overview of the contributions in this special issue; and some ideas for post-pandemic economic research.
Knowledge attribution, socioeconomic status, and education: new results using the Great British Class Survey
Authors: de Bruin Boudewijn
Published: September 2021

This paper presents new evidence on the impact of socioeconomic status (SES) and education on knowledge attribution. I examine a variety of cases, including vignettes where agents have been Gettiered, have false beliefs, and possess knowledge (according to orthodoxy). Early work investigated whether SES might be associated with knowledge attribution (Weinberg et al. in Philos Top 29(1–2):429–460, 2001; Seyedsayamdost in Episteme 12(1):95–116, 2014). But these studies used college education as a dummy variable for SES. I use the recently developed Great British Class Survey (Savage et al. in Sociology 47(2):219–250, 2013) to measure SES. The paper reports evidence against an association between SES and patterns of knowledge ascription, and reports mixed evidence about education effects.
Scrum methodology in context-based secondary chemistry classes: effects on students’ achievement and on students’ perceptions of affective and metacognitive dimensions of their learning
Authors: Vogelzang Johannes , Admiraal Wilfried F. , van Driel Jan H.
Published: September 2021

Teaching with Scrum methodology includes ceremonies, roles and artefacts supporting students in planning, monitoring and directing their learning process. It scaffolds students’ learning in complex and sometimes overwhelming context-based learning environments. Effects of the implementation on both students’ learning outcomes and self-reported perceptions of six affective and metacognitive outcomes were investigated. Six teachers implemented Scrum methodology in a context-based secondary chemistry module on Green Chemistry. Their classes formed the experimental group. Based on how students experienced the quality of the implementation, teachers of the experimental group were subdivided into top-teachers and growth-teachers. Consequently, their students formed two sub-experimental groups. The comparison group, which did not use Scrum methodology, consisted of students taught by four teachers. A pre-test post-test control group design was used to study its effect on students’ achievements and self-reported affective and metacognitive outcomes. Students of both experimental groups outperformed students of the comparison group with a large effect-size (top-teachers); and medium effect-size (growth-teachers) on learning outcomes. Findings on students’ perceptions of affective and metacognitive outcomes revealed medium and small effects of Scrum methodology. Despite the fact that the implementation is challenging for teachers, it appears that Scrum methodology has positive effects on students’ achievement and on students’ perceptions of affective and metacognitive dimensions of their learning.
Implementation barriers to integrating exercise as medicine in oncology: an ecological scoping review
Authors: Kennedy Mary A. , Bayes Sara , Newton Robert U. , Zissiadis Yvonne , Spry Nigel A. , Taaffe Dennis R. , Hart Nicolas H. , Galvão Daniel A.
Published: September 2021

Purpose

While calls have been made for exercise to become standard practice in oncology, barriers to implementation in real-world settings are not well described. This systematic scoping review aimed to comprehensively describe barriers impeding integration of exercise into routine oncology care within healthcare systems.

Methods

A systematic literature search was conducted across six electronic databases (since 2010) to identify barriers to implementing exercise into real-world settings. An ecological framework was used to classify barriers according to their respective level within the healthcare system.

Results

A total of 1,376 results were retrieved; 50 articles describing implementation barriers in real-world exercise oncology settings were reviewed. Two hundred and forty-three barriers were identified across all levels of the healthcare system. Nearly 40% of barriers existed at the organizational level (n = 93). Lack of structures to support exercise integration and absence of staff/resources to facilitate its delivery were the most common issues reported. Despite the frequency of barriers at the organizational level, organizational stakeholders were largely absent from the research.

Conclusions

Implementing exercise into routine cancer care is hindered by a web of interrelated barriers across all levels of the healthcare system. Organizational barriers are central to most issues. Future work should take an interdisciplinary approach to explore best practices for overcoming implementation barriers, with organizations as a central focus.

Implications for Cancer Survivors

This blueprint of implementation barriers highlights critical issues that need to be overcome to ensure people with cancer have access to the therapeutic benefits of exercise during treatment and beyond.