bluuebunny/crossref_metadata_2025 huggingface dataset:
A real-world disproportionality analysis of mesalazine data mining of the public version of FDA adverse event reporting system
Authors: Liu Mingdi , Gu Liting , Zhang Yuning , Zhou Honglan , Wang Yishu , Xu Zhi-Xiang
Published: January 2024

Background: Mesalazine, a preparation of 5-aminosalicylic acid, is a medication widely used in clinical practice as a first-line therapy in the treatment of mild and moderate inflammatory bowel disease. However, the long-term safety of mesalazine in large sample population was unknown. The current study was to assess mesalazine -related adverse events of real-world through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods: Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio the Bayesian confidence propagation neural network and the multi-item gamma Poisson shrinker (MGPS) algorithms were employed to quantify the signals of mesalazine -associated AEs.

Results: Out of 14,149,980 reports collected from the FDA Adverse Event Reporting System database, 24,284 reports of mesalazine -associated AEs were identified. A total of 170 significant disproportionality preferred terms conforming to the four algorithms simultaneously were retained. The most common AEs included colitis ulcerative, diarrhoea, condition aggravated, crohn’s disease, fatigue, abdominal pain, nausea, haematochezia, which were corresponding to those reported in the specification and clinical trials. Unexpected significant AEs as dizziness, drug ineffective, drug hypersensitivity, infection, off label use, weight decreased, decreased appetite, arthralgia, rash might also occur. The median onset time of mesalazine -related AEs was 1,127 days (interquartile range [IQR] 1,127–1,674 days), and most of the cases occurred 2 years later (n = 610, 70.93%) and within the first 1 month (n = 89, 10.35%) after mesalazine initiation.

Conclusion: Results of our study were consistent with clinical observations. We also found potential new and unexpected AEs signals for mesalazine, suggesting prospective clinical studies were needed to confirm these results and illustrate their relationship. Our results could provide valuable evidence for further safety studies of mesalazine.
Deep learning-based predictive model for pathological complete response to neoadjuvant chemotherapy in breast cancer from biopsy pathological images: a multicenter study
Authors: Zeng Huancheng , Qiu Siqi , Zhuang Shuxin , Wei Xiaolong , Wu Jundong , Zhang Ranze , Chen Kai , Wu Zhiyong , Zhuang Zhemin
Published: January 2024

Introduction: Early predictive pathological complete response (pCR) is beneficial for optimizing neoadjuvant chemotherapy (NAC) strategies for breast cancer. The hematoxylin and eosin (HE)-stained slices of biopsy tissues contain a large amount of information on tumor epithelial cells and stromal. The fusion of pathological image features and clinicopathological features is expected to build a model to predict pCR of NAC in breast cancer.

Methods: We retrospectively collected a total of 440 breast cancer patients from three hospitals who underwent NAC. HE-stained slices of biopsy tissues were scanned to form whole-slide images (WSIs), and pathological images of representative regions of interest (ROI) of each WSI were selected at different magnifications. Based on several different deep learning models, we propose a novel feature extraction method on pathological images with different magnifications. Further, fused with clinicopathological features, a multimodal breast cancer NAC pCR prediction model based on a support vector machine (SVM) classifier was developed and validated with two additional validation cohorts (VCs).

Results: Through experimental validation of several different deep learning models, we found that the breast cancer pCR prediction model based on the SVM classifier, which uses the VGG16 model for feature extraction of pathological images at ×20 magnification, has the best prediction efficacy. The area under the curve (AUC) of deep learning pathological model (DPM) were 0.79, 0.73, and 0.71 for TC, VC1, and VC2, respectively, all of which exceeded 0.70. The AUCs of clinical model (CM), a clinical prediction model established by using clinicopathological features, were 0.79 for TC, 0.73 for VC1, and 0.71 for VC2, respectively. The multimodal deep learning clinicopathological model (DPCM) established by fusing pathological images and clinicopathological features improved the AUC of TC from 0.79 to 0.84. The AUC of VC2 improved from 0.71 to 0.78.

Conclusion: Our study reveals that pathological images of HE-stained slices of pre-NAC biopsy tissues can be used to build a pCR prediction model. Combining pathological images and clinicopathological features can further enhance the predictive efficacy of the model.
Phylogenetic and functional analysis of tiller angle control homeologs in allotetraploid cotton
Authors: Kangben Foster , Kumar Sonika , Li Zhigang , Sreedasyam Avinash , Dardick Chris , Jones Don , Saski Christopher A.
Published: January 2024

Introduction

Plants can adapt their growth to optimize light capture in competitive environments, with branch angle being a crucial factor influencing plant phenotype and physiology. Decreased branch angles in cereal crops have been shown to enhance productivity in high-density plantings. The Tiller Angle Control (TAC1) gene, known for regulating tiller inclination in rice and corn, has been found to control branch angle in eudicots. Manipulating TAC1 in field crops like cotton offers the potential for improving crop productivity.

Methods

Using a homolog-based methodology, we examined the distribution of TAC1-related genes in cotton compared to other angiosperms. Furthermore, tissue-specific qPCR analysis unveiled distinct expression patterns of TAC1 genes in various cotton tissues. To silence highly expressed specific TAC1 homeologs in the stem, we applied CRISPR-Cas9 gene editing and Agrobacterium-mediated transformation, followed by genotyping and subsequent phenotypic validation of the mutants.

Results

Gene duplication events of TAC1 specific to the Gossypium lineage were identified, with 3 copies in diploid progenitors and 6 copies in allotetraploid cottons. Sequence analysis of the TAC1 homeologs in Gossypium hirsutum revealed divergence from other angiosperms with 1-2 copies, suggesting possible neo- or sub-functionalization for the duplicated copies. These TAC1 homeologs exhibited distinct gene expression patterns in various tissues over developmental time, with elevated expression of A11G109300 and D11G112200, specifically in flowers and stems, respectively. CRISPR-mediated loss of these TAC1 homeologous genes resulted in a reduction in branch angle and altered petiole angles, and a 5 to 10-fold reduction in TAC1 expression in the mutants, confirming their role in controlling branch and petiole angles. This research provides a promising strategy for genetically engineering branch and petiole angles in commercial cotton varieties, potentially leading to increased productivity.
Research progress on Brassicaceae plants: a bibliometrics analysis
Authors: Zhou Ruixue , Qin Xinsheng , Hou Junjun , Liu Yining
Published: January 2024

The Brassicaceae is a worldwide family that produces ornamental flowers, edible vegetables, and oilseed plants, with high economic value in agriculture, horticulture, and landscaping. This study used the Web of Science core dataset and the CiteSpace bibliometric tool to quantitatively visualize the number of publications, authors, institutions, and countries of 3139 papers related to Brassicaceae plants from 2002 to 2022. The keywords and references were divided into two phases: Phase 1 (2002-2011) and Phase 2 (2012-2022) for quantitative and qualitative analysis. The results showed: An average annual publication volume of 149 articles, with an overall fluctuating upward trend; the research force was mainly led by Professor Ihsan A. Al-shehbaz from Missouri Botanical Garden; and the United States had the highest number of publications. In the first phase, research focused on the phylogeny of Brassicaceae plants, while the second phase delved into diverse research based on previous studies, research in areas such as polyploidy, molecular technique, physiology, and hyperaccumulator has been extended. Based on this research, we propounded some ideas for future studies on Brassicaceae plants and summarized the research gaps.
Unveiling the potential of cellulose nanofibre based nitrogen fertilizer and its transformative effect on Vigna radiata (Mung Bean): nanofibre for sustainable agriculture
Authors: Sharma Neha , Kochar Mandira , Allardyce Benjamin James , Rajkhowa Rangam , Agrawal Ruchi
Published: January 2024

Introduction

Fertilizer management is crucial to maintaining a balance between environmental health, plant health, and total crop yield. Farmers are overutilizing fertilizers with a mind set to enhance the productive capacity of the field, which adversely impacts soil fertility and causes serious environmental hazards. To mitigate the issues of over-utilization of fertilizers, controlled-release fertilizers were developed using nitrogen fertilizer (ammonium chloride) loaded on cellulose nanofibres (named CNF*N).

Methodology

In this study, the effects of CNF*N were compared with commercial nitrogen fertilizer (ammonium chloride) on Vigna radiata (Mung) under greenhouse conditions. The pot experiment was conducted using six treatments: first treatment was control, where the plant was cultivated (T1); second treatment was T2, where the plant was cultivated with CNF to determine the impact of CNF on the plant; third was T3 where commercial ammonium chloride (24 mg/ 2 kg soil) was added to the plant; fourth was T4, where the plant was loaded with CNF, viz. CNF*N contains 4.8 mg of nitrogen; fifth was T5 CNF*N pellet contains 12 mg of nitrogen, and the last sixth treatment (T6) where CNF*N pellet containing 24 mg of nitrogen.

Results

It indicated that the growth parameters were best achieved in T6 treatment. Plant height was at its maximum in the T6 treatment (44.4 ±0.1cm) after the second harvest, whereas the minimum plant height was observed in T1, which was 39.1 ±0.1 cm. Root-to-shoot weight ratio was also maximum in T6 (0.183± 0.02) and minimum in T1 (0.07± 0.01) after second harvesting. The significant difference among the treatments was determined with Tukey’s honestly significant difference (HSD). The nitrogen content (available and total) was significantly higher in the T4, T5, and T6 treatments (0.22, 0.25, and 0.28%) as compared to the control treatments (T1 (0.12%), T2 (0.13%), and T3 (0.14%) during the second harvesting stage (90 days), as nitrogen plays a crucial role in the development of vegetative growth in Vigna radiata. The rate of controlled-release nitrogen-fertilizer was found to be optimal in terms of plant growth and soil nutrients; hence, it could potentially play a crucial role in improving soil health and the yield of the crop.
Effect of parental rearing styles on adolescent ego identity: the mediating role of involutionary attitudes
Authors: Ding Yan , Sun Changan , Dong Bo
Published: January 2024

Previous studies have found that negative parental rearing styles can negatively predict the acquisition of ego identity, while it has not been discussed whether the overcompetitive attitudes, a stable personality, will further hinder their ego identity development under the model of educational involutionary. The study used the Overcompetitive Attitude Scale, the Brief Parental Rearing Styles Questionnaire, and the Ego Identity Status Scale to investigate 550 young students in a school in Suzhou in order to explore the influence of parental rearing styles on adolescents’ ego identity development and the role of involutional attitudes. The results showed that: (1) Adolescents’ overcompetitive attitude was positively predicted by parental rejection and overprotection, while it was negatively predicted by parental emotional warmth. (2) Parental emotional warmth significantly predicted adolescents’ ego identity status more favorably than parental rejection, overprotection, and overcompetitive attitude. (3) Overcompetitive attitude plays a partial intermediary role between parental rearing style and ego identity.
A study on Taiwan’s vocational senior high school teachers’ teaching identity and teaching transformation when facing a new competency-based curriculum
Authors: Lin Tzu-Chien , Lee Yi-Sang , Ye Jian-Hong
Published: January 2024

Introduction

The competency of education is advocated in the 2023 United Nations Sustainable Development Goals. UNESCO encourages countries to provide inclusive, equitable, competency education and lifelong learning opportunities for all. Starting from 2019, 12-Year-Basic-Education, a new curriculum, was fully implemented in Taiwan to conform to the competency education strategy. For the teachers on site, teachers’ understanding of the new curriculum and teaching practice has a direct impact on the competency of the implementation of this new policy. The main purpose of this study was to explore the relationship between vocational senior high school teachers’ competency-oriented teaching, teaching identity and teaching transformation regarding this new curriculum.

Methods

In order to effectively expand teachers’ understanding of competency-oriented teaching identity, this study put forward 6 hypothetical approaches based on the implicit theory of teaching transformation. The 747 valid questionnaires accounted for 97.1% of the total recovered questionnaires. The reliability and validity analyses, as well as overall model fitting analysis and research model validation were performed on these valid questionnaires.

Results

The results of the study showed: (1) With the background of Competency-oriented teaching, teachers’ teaching attitude and teaching willingness has a positive impact on teaching identity; (2) teachers’ teaching identity has a positive impact on teaching preparation, teaching practice, further study, three types of teaching transformation. In summary, three conclusions from this study were concluded on the aspects of teaching preparation, teaching practice and further study on practical competency-oriented teaching, teaching identity and teaching transformation in the educational field.

Conclusion

Three conclusions were derived for the relationships among these six constructs: (1) Teachers with a “good attitude” and “strong willingness” to teach, a “high sense of identification” acceptance and full implement of “teaching preparation” are considered as teachers with a “foresight and a visionary predictive style”; (2) Teachers with a high sense of self-awareness who can fully practice “teaching practice” are teachers with a “pragmatic teaching by example style”; (3) Teachers with a “good attitude,” a “strong willingness” to teach, a “high sense of identification” acceptance and who are able to fully practice “advanced research” are considered as teachers with an “empowerment-enhancing coaching style”.
Lonely and scrolling during the COVID-19 pandemic: understanding the problematic social media use and mental health link among university students
Authors: Ghanayem Leen K. , Shannon Holly , Khodr Lida , McQuaid Robyn J. , Hellemans Kim G.C.
Published: January 2024

Introduction

Undergraduate university students experienced many academic and non-academic stressors during the first year of the coronavirus (COVID-19) pandemic, putting them at a greater risk of negative mental health outcomes. Reports worldwide have shown high incidences of depressive, anxiety, and stress scores among university students at the beginning of the pandemic. Emerging evidence also suggests that to cope with the stress and loneliness of the pandemic, many youth and young adults increased the amount of time they spent on social media platforms.

Methods

Undergraduate students participated in an online study aimed to understand the link between time spent on social media, coping through the use of social media and problematic social media use (PSMU) with mental health symptoms, such as stress, depression, anxiety, and loneliness, during the COVID-19 pandemic.

Results

While time spent on social media was only weakly associated with stress, depression, anxiety and loneliness scores, PSMU more strongly mapped onto these outcomes. Additionally, students who were coping highly using social media displayed elevated stress, depression, anxiety and loneliness levels in comparison to those reporting low levels of coping with social media. Finally, students who reported high levels of coping using social media displayed higher PSMU scores, with this relationship appearing more pronounced in students who had higher levels of loneliness.

Conclusion

These data support evidence that it is not necessarily time spent on social media but rather PSMU that is relevant for mental health symptoms, and that PSMU is exacerbated by loneliness. Moreover, the current results highlight the effects of maladaptive coping on mental health symptoms and PSMU among university students during the COVID-19 pandemic.
A comparison of the substance use related risk and protective factor profiles for American Indian and White American youth: a mixed studies review
Authors: Nadeau Melanie , Wise Kathryn , Sabbella Revathi B. , Olson Devon
Published: January 2024

Background

American Indian youth are disproportionately impacted by substance use compared to White American youth in the United States. This mixed studies review focused on gathering data to examine the similarities and differences between the risk and protective factor profiles for substance use among American Indian and White American youth aged 10–21.

Methods

A scan of the existing literature was needed to review substance use related risk and protective factors for American Indian and White American youth. Search phrases were created to ensure maximum relevant results from existing literature through 2021. After deduplication, an appraisal tool was utilized to review 343 records. A total of 19 articles were deemed relevant. Data from relevant articles was recorded and categorized into the levels of the Social Ecological Model.

Results

Significant and salient risk and protective factors of substance use for both American Indian and White American youth presented at the individual, interpersonal (family/non-family), and community levels of the Social Ecological Model. A total of 84 factors were found from relevant articles, 55 risk factors and 29 protective factors. When comparing the American Indian and White American youth profiles, a total of 29 unique differences between American Indian (n = 21) and White American youth (n = 8) were identified.

Discussion

Results from this review can be utilized to inform Tribal leaders, stakeholders, and policymakers, which will ultimately influence health intervention strategies and prioritizations. Given the limited evidence though, researchers should be responsive to Tribal communities’ call to action for utilizing a culturally rooted approach.
Exploring positive psychology intervention and mindfulness-based intervention in nature: impact on well-being of school students in India
Authors: Chhajer Raina , Hira Nainika
Published: January 2024

Introduction

Enhancing the well-being of urban school students is a growing challenge. The online mode of teaching during and post-pandemic era has increased students’ daily screen time. As they spend more time indoors, they tend to disconnect from nature even more, adversely impacting their well-being. This study aimed to design and execute two well-being interventions—a positive psychology intervention (PPI) and a mindfulness-based intervention (MBI) in natural settings for urban school students in India.

Methods

One hundred eighty participants (aged 17–20) from a senior secondary school were randomly assigned to three groups: PPI, MBI, and a control group (CTR). Participants self-reported their levels of well-being, gratitude, inclusion of nature in self, sense of connectedness, resilience, awareness, perceived stress, and positive and negative emotions using a survey questionnaire at two times—pre- and post-interventions. Repeated-measures ANOVA was employed across time and groups, and post hoc analyses for group differences were carried out through the Bonferroni test.

Results

Results indicate that both PPI and MBI interventions, when executed in natural settings, enhance student well-being, gratitude, inclusion of nature in self, sense of connectedness, resilience, awareness, positive emotions and decreased levels of perceived stress, and negative emotions.

Discussion

The study provides valuable insights for school authorities, policymakers, and urban planners to include natural settings in school premises and offer well-being interventions for students to connect with nature consciously.
First deployment of artificial intelligence recommendations in orthopedic surgery
Authors: Al Zoubi Farid , Kashanian Koorosh , Beaule Paul , Fallavollita Pascal
Published: January 2024

Scant research has delved into the non-clinical facets of artificial intelligence (AI), concentrating on leveraging data to enhance the efficiency of healthcare systems and operating rooms. Notably, there is a gap in the literature regarding the implementation and outcomes of AI solutions. The absence of published results demonstrating the practical application and effectiveness of AI in domains beyond clinical settings, particularly in the field of surgery, served as the impetus for our undertaking in this area. Within the realm of non-clinical strategies aimed at enhancing operating room efficiency, we characterize OR efficiency as the capacity to successfully perform four uncomplicated arthroplasty surgeries within an 8-h timeframe. This Community Case Study addresses this gap by presenting the results of incorporating AI recommendations at our clinical institute on 228 patient arthroplasty surgeries. The implementation of a prescriptive analytics system (PAS), utilizing supervised machine learning techniques, led to a significant improvement in the overall efficiency of the operating room, increasing it from 39 to 93%. This noteworthy achievement highlights the impact of AI in optimizing surgery workflows.
Emergent communication of multimodal deep generative models based on Metropolis-Hastings naming game
Authors: Hoang Nguyen Le , Taniguchi Tadahiro , Hagiwara Yoshinobu , Taniguchi Akira
Published: January 2024

Deep generative models (DGM) are increasingly employed in emergent communication systems. However, their application in multimodal data contexts is limited. This study proposes a novel model that combines multimodal DGM with the Metropolis-Hastings (MH) naming game, enabling two agents to focus jointly on a shared subject and develop common vocabularies. The model proves that it can handle multimodal data, even in cases of missing modalities. Integrating the MH naming game with multimodal variational autoencoders (VAE) allows agents to form perceptual categories and exchange signs within multimodal contexts. Moreover, fine-tuning the weight ratio to favor a modality that the model could learn and categorize more readily improved communication. Our evaluation of three multimodal approaches - mixture-of-experts (MoE), product-of-experts (PoE), and mixture-of-product-of-experts (MoPoE)–suggests an impact on the creation of latent spaces, the internal representations of agents. Our results from experiments with the MNIST + SVHN and Multimodal165 datasets indicate that combining the Gaussian mixture model (GMM), PoE multimodal VAE, and MH naming game substantially improved information sharing, knowledge formation, and data reconstruction.
Design and sequential jumping experimental validation of a musculoskeletal bipedal robot based on the spring-loaded inverted pendulum model
Authors: Li Yiqi , Jiang Yelin , Hosoda Koh
Published: January 2024

To effectively control a robot’s motion, it is common to employ a simplified model that approximates the robot’s dynamics. Nevertheless, discrepancies between the actual mechanical properties of the robot and the simplified model can result in motion failures. To address this issue, this study introduces a pneumatic-driven bipedal musculoskeletal robot designed to closely match the mechanical characteristics of a simplified spring-loaded inverted pendulum (SLIP) model. The SLIP model is widely utilized in robotics due to its passive stability and dynamic properties resembling human walking patterns. A musculoskeletal bipedal robot was designed and manufactured to concentrate its center of mass within a compact body around the hip joint, featuring low leg inertia in accordance with SLIP model principles. Furthermore, we validated that the robot exhibits similar dynamic characteristics to the SLIP model through a sequential jumping experiment and by comparing its performance to SLIP model simulation.
Addendum: Development and evaluation of a school-based physical literacy intervention for children in Germany: protocol of the PLACE study
Authors: Pöppel Katharina , Schmittwilken Louisa , Carl Johannes
Published: January 2024

Pilot studies serve to explore the feasibility of assessment instruments and intervention arrangements. As there have not been any validated German physical literacy (PL) assessments for children, we originally included four translated instruments into the pilot phases of the PLACE study, which aimed to test the effectiveness of a theory-based PL intervention for the extracurricular time at primary schools for pupils in Bremen of grades three to four. Unfortunately, the exploratory analyses revealed that all quantitative PL instruments, despite extensive revision throughout the pilot waves, showed insufficient reliability and validity. Against this background, we have to adjust the main phase of the study and deviate meaningfully from our initial study protocol with mixed-methods character [Carl, J., Schmittwilken, L., & Pöppel, K. (2023). Development and evaluation of a school-based physical literacy intervention for children in Germany: protocol of the PLACE study. Frontiers in Sports and Active Living, 5, 1155363. doi: 10.3389/fspor.2023.1155363] by dissolving the quantitative part in favor of a qualitative study with multiple data sources (multiperspective discussion panel, session protocols, group interviews). We want to transparently communicate this re-arrangement prior to the main phase.
Long-term functional swallowing and speech outcomes after transoral robotic surgery for oropharyngeal cancer
Authors: Ji Yong Bae , Choi Hae Won , Song Chang Myeon , Yun Bo Ram , Park Hae Jin , Oh Sukjoong , Tae Kyung
Published: January 2024

Objectives

Transoral robotic surgery (TORS) has emerged as a minimally invasive approach for oropharyngeal cancer, aiming to improve functional preservation and reduce morbidity. However, the long-term effects on speech and swallowing, crucial aspects of quality of life, remain unclear. This study investigates the long-term functional swallowing and speech outcomes of TORS for oropharyngeal cancer.

Methods

We retrospectively reviewed 41 patients diagnosed with oropharyngeal squamous cell carcinoma who underwent TORS from 2010 to 2018. Tongue mobility, articulation, verbal diadochokinesis, reading speed, and modified barium swallowing tests were performed 2–3 years post-operatively to assess long-term speech and swallowing function.

Results

The mean age was 57.7 ± 9.9 years, and the male to female ratio was 34:7. The palatine tonsil was the most common tumor site (73.2%), followed by the base of tongue (22.0%). Concurrent neck dissection was performed in 97.6% of patients, and adjuvant radiation or chemoradiation was administered to 36 patients (87.8%). Tongue mobility, articulation, verbal diadochokinesis, and reading speed were comparable to normal population. Modified barium swallowing tests revealed acceptable outcomes in most patients; only one patient (2.4%) required a percutaneous endoscopic gastrostomy tube. Notably, no permanent tracheostomies were necessary.

Conclusions

Long-term speech and swallowing functions were preserved in most patients treated with TORS for oropharyngeal cancer. TORS is an excellent treatment modality for oropharyngeal cancer in terms of functional outcomes.
Soluble Receptor for Advanced Glycation End Products (sRAGE) Level and Its Prognostic Significance in Children with Acute Lymphoblastic Leukemia
Authors: Ozkan Busra , Altuner Torun Yasemin , Karakukcu Cigdem , Celik Binnaz
Published: January 2024

Acute lymphoblastic leukemias are the most common malignancies in childhood. Although its etiology is still unclear, it is thought that disorders in oxidative stress metabolism may contribute to leukemogenesis. Advanced glycation end products (AGEs) are formed as a result of the non-enzymatic binding of sugars to biomolecules. Oxidation reactions are triggered through AGE–Receptor (RAGE) interaction, resulting in the formation of reactive oxygen species. These can play crucial roles in cancer pathogenesis and leukemogenesis. It is thought that sRAGE (soluble RAGE) is the end product of glycation and circulates freely in the circulation by binding to RAGE ligands. We investigate novel leukemia biomarkers and focus on soluble RAGE (sRAGE) for acute lymphoblastic leukemia (ALL) diagnosis and prognosis. Thirty children (1–17 years) diagnosed with ALL were included in the study. Patients were divided into standard, medium, and high risk groups according to the Berlin–Frankfurt–Münster (BFM) treatment protocol. Patients were evaluated twice; at the time of diagnosis and at the sixth month of remission. sRAGE and blood parameters were compared with healthy controls (n = 30, 1–17 years). The sRAGE levels in ALL patients at diagnosis (138.7 ± 177.3 pg/mL) were found to be significantly higher than they were during the sixth month of remission (17.6 ± 21.1 pg/mL) and in healthy controls (22.2 ± 23.7 pg/mL). The cut-off value of the sRAGE level for the diagnosis of ALL was found to be 45 pg/mL in ROC analysis (sensitivity: 73.3%, specificity: 86.7%, AUC: 0.681). At the same time, the sRAGE level was found to be significantly higher in T-ALL patients (490.9 ± 236.9 pg/mL) than in B-ALL patients (84.5 ± 82.7 pg/mL). No significant difference was found in terms of the sRAGE level between standard (45.8± 33.1 pg/mL), medium (212 ± 222.1 pg/mL), and high (143.9 ± 111.5 pg/mL) risk group ALL patients classified according to the BFM protocol. Despite the fact that this was a small, single-center study, our findings highlight the potential use of sRAGE as a biomarker for diagnosing ALL and assessing response to treatment.
Lignocellulosic Biomass Valorisation by Coupling Steam Explosion Treatment and Anaerobic Digestion
Authors: Chaib Oumaima , Abatzoglou Nicolas , Achouri Inès Esma
Published: January 2024

Lignocellulosic biomass valorisation presents a promising avenue for sustainable and renewable energy production. In this study, the synergistic potential of coupling steam explosion (SE) treatment with anaerobic digestion (AD) was explored to maximize the efficient conversion of lignocellulosic biomass into valuable biogas. The SE process, a cost-effective technique for biomass fractionation, plays a pivotal role in breaking down complex biomass components, rendering them more amenable to subsequent biological treatments. In the present work, we investigated the impact of various SE conditions, including temperature, time, and acid concentration, on the breakdown of lignocellulosic residues. Through the quantification and analysis of sugars and their degradation products, the optimization of steam explosion conditions at lower temperatures and shorter time periods, along with the presence of a lower concentration of acid catalysts, efficiently releases sugars. Maintaining these conditions helps prevent byproducts. The evaluation of the (S/I)vs ratio during anaerobic digestion reveals an optimal 1/2 ratio, maximizing biogas production. This innovative approach demonstrates significant potential for the valorisation of lignocellulosic biomass, contributing to a more sustainable and efficient utilization of renewable resources in the pursuit of clean energy solutions.
Optimizing CO2-Water Injection Ratio in Heterogeneous Reservoirs: Implications for CO2 Geo-Storage
Authors: Al-Khdheeawi Emad A.
Published: January 2024

The performance of carbon geo-sequestration is influenced by several parameters, such as the heterogeneity of the reservoir, the characteristics of the caprock, the wettability of the rock, and the salinity of the aquifer brine. Although many characteristics, like the formation geology, are fixed and cannot be altered, it is feasible to choose and manipulate other parameters in order to design an optimized storage programme such as the implementation of CO2 injection techniques, including continuous injection or water alternating CO2, which can significantly increase storage capacity and guarantee secure containment. Although WAG (water-alternating-gas) technology has been widely applied in several industrial sectors such as enhanced oil recovery (EOR) and CO2 geo-sequestration, the impact of the CO2-to-water ratio on the performance of CO2 geo-sequestration in heterogeneous formations has not been investigated. In this study, we have constructed a 3D heterogeneous reservoir model to simulate the injection of water alternating gas in deep reservoirs. We have tested several CO2-water ratios, specifically the 2:1, 1:1, and 1:2 ratios. Additionally, we have estimated the capacity of CO2 trapping, as well as the mobility and migration of CO2. Our findings indicate that injecting a low ratio of CO2 to water (specifically 1:2) resulted in a much better performance compared to situations with no water injection and high CO2-water ratios. The residual and solubility trappings were notably increased by 11% and 19%, respectively, but the presence of free mobile CO2 was reduced by 27%. Therefore, in the reservoir under investigation, the lower CO2-water ratio is recommended due to its improvement in CO2 storage capacity and containment security.
Factoring Building Refurbishment and Climatic Effect into Heat Demand Assessments and Forecasts: Case Study and Open Datasets for Germany
Authors: Salaymeh Abdulraheem , Peters Irene , Holler Stefan
Published: January 2024

Reducing the heat demand of existing buildings is an essential prerequisite for achieving a greenhouse gas-neutral energy supply. Numerous studies and open-source tools deal with heat demand mapping. It is not uncommon that estimated heat demands deviate from real heat consumption, so existing approaches should be improved by including in-depth building information. Some tools have recognised this problem and offer built-in functions for factoring various parameters into their assessments. Nevertheless, the necessary information is usually missing and should be obtained first. In this paper, we analyse the impact of thermal refurbishment and climate on building heat demand; hence, generate public datasets with corresponding key figures for each building type in different efficiency states and years. Accounting for already performed refurbishments in methodologies for assessing the actual state heat demand for cities will result in a reduction of at least 8% up to more than 21%, depending on whether conventional or passive house components were installed. As a result of climatic differences within Germany, a building’s heat demand can be up to 39% higher or up to 21% lower than the heat demand of an identical building in the reference climate of Germany. By further developing the approaches of the tools Hotmaps and Heat Cadastre Hamburg, we could improve the estimated heat demand of Hamburg to a value approximating the real consumption.
Differences in Game Dynamics between High-Level Volleyball and Beach Volleyball Matches
Authors: Đurković Tomislav , Babok Domagoj , Rešetar Tomica
Published: January 2024

The aim of this research is to verify whether there is a difference in the average duration of the active and passive phases of the game between volleyball and beach volleyball. A total of 2392 active and passive phases were measured during high-level volleyball and beach volleyball matches for males. Matches were played by four teams (53 players) in indoor volleyball (age 29 ± 4.94 years) and five teams (10 players) in beach volleyball (age 28.27 ± 6.64 years). Possible differences were evaluated using the Mann–Whitney U test. The average duration of the active phase in volleyball is 5.55 s ± 4.38 s. In beach volleyball, the active phase lasts marginally longer, at 6.00 s ± 3.44 s. The average duration of the passive phase in volleyball is 35.27 s ± 25.96 s and it lasts longer than the average passive phase in beach volleyball at 33.82 s ± 22.98 s. The Mann–Whitney U test showed a statistically significant difference (p = 0.00) between the active phases in volleyball (Md = 3.53, n = 727) and beach volleyball (Md = 3.43, n = 484), U = 140770.00, z = −5.90 with small effect according to Cohen’s criterion (r = 0.14). The Mann–Whitney U test (U = 160773.00, z = −1.10) showed no statistically significant difference in the average duration of the passive phases at volleyball and beach volleyball. This research determined that there is a statistically significant difference in the average duration of the active phase between volleyball and beach volleyball. The new insights gained in this research can support a more precise programming of training intensity in high-level volleyball and beach volleyball.
Weathered Coal-Immobilized Microbial Materials as a Highly Efficient Adsorbent for the Removal of Lead
Authors: Jiao Zile , Gao Chunhua , Li Jianhua , Lu Jinjing , Wang Juan , Li Lin , Chen Xiaojing
Published: January 2024

Most research on immobilized microorganisms employs biomass charcoal as a carrier, but limited studies explore coal-based resources for microbial immobilization. Herein, lead-resistant functional strains were immobilized using weathered coal as a carrier, resulting in the development of a weathered coal-immobilized microbial material (JK-BW) exhibiting high efficiency in lead removal from solutions. A quadratic polynomial model for the adsorption capacity and adsorption rate of JK-BW on Pb2+ was developed using the Box-Behnken method to determine the optimal adsorption conditions. The Pb2+ adsorption mechanism of JK-BW was studied through batch adsorption and desorption experiments along with SEM-EDS, BET, FT-IR, and XPS analyses. Findings indicated that optimal conditions were identified at 306 K temperature, 0.36 g/L adsorbent dosage, and 300 mg/L initial solution concentration, achieving a peak adsorption performance of 338.9 mg/g (308 K) for the immobilized material, surpassing free cell adsorption by 3.8 times. Even after four cycles of repeated use, the material maintained its high adsorption capacity. Pb2+ adsorption by JK-BW involved monolayer chemisorption with ion exchange, complexation, precipitation, physical adsorption, and microbial intracellular phagocytosis. Ion exchange accounted for 22–42% and complexation accounted for 39–57% of the total adsorption mechanisms, notably involving exchanges with K, Ca, Na, and Mg ions as well as complexation with –OH, –COOH, CO–OH, –COOH, CO–, NH2, and the β-ring of pyridine for Pb2+ adsorption.
Reversible Surface Energy Storage in Molecular-Scale Porous Materials
Authors: Bratko Dusan
Published: January 2024

Forcible wetting of hydrophobic pores represents a viable method for energy storage in the form of interfacial energy. The energy used to fill the pores can be recovered as pressure–volume work upon decompression. For efficient recovery, the expulsion pressure should not be significantly lower than the pressure required for infiltration. Hysteresis of the wetting/drying cycle associated with the kinetic barrier to liquid expulsion results in energy dissipation and reduced storage efficiency. In the present work, we use open ensemble (Grand Canonical) Monte Carlo simulations to study the improvement of energy recovery with decreasing diameters of planar pores. Near-complete reversibility is achieved at pore widths barely accommodating a monolayer of the liquid, thus minimizing the area of the liquid/gas interface during the cavitation process. At the same time, these conditions lead to a steep increase in the infiltration pressure required to overcome steric wall/water repulsion in a tight confinement and a considerable reduction in the translational entropy of confined molecules. In principle, similar effects can be expected when increasing the size of the liquid particles without altering the absorbent porosity. While the latter approach is easier to follow in laboratory work, we discuss the advantages of reducing the pore diameter, which reduces the cycling hysteresis while simultaneously improving the stored-energy density in the material.
Gas-Phase Infrared Action Spectroscopy of CH2Cl+ and CH3ClH+: Likely Protagonists in Chlorine Astrochemistry
Authors: Thorwirth Sven , Steenbakkers Kim , Danowski Timon , Schmid Philipp C. , Bonah Luis , Asvany Oskar , Brünken Sandra , Schlemmer Stephan
Published: January 2024

Two fundamental halocarbon ions, CH2Cl+ and CH3ClH+, were studied in the gas phase using the FELion 22-pole ion trap apparatus and the Free Electron Laser for Infrared eXperiments (FELIX) at Radboud University, Nijmegen (the Netherlands). The vibrational bands of a total of four isotopologs, CH235,37Cl+ and CH335,37ClH+, were observed in selected wavenumber regions between 500 and 2900 cm−1 and then spectroscopically assigned based on the results of anharmonic force field calculations performed at the CCSD(T) level of theory. As the infrared photodissociation spectroscopy scheme employed probes singly Ne-tagged weakly bound complexes, complementary quantum-chemical calculations of selected species were also performed. The impact of tagging on the vibrational spectra of CH2Cl+ and CH3ClH+ is found to be virtually negligible for most bands; for CH3ClH+–Ne, the observations suggest a proton-bound structural arrangement. The experimental band positions as well as the best estimate rotational molecular parameters given in this work provide a solid basis for future spectroscopic studies at high spectral resolutions.
Ultra-High-Performance Liquid Chromatography–Electrospray Ionization–High-Resolution Mass Spectrometry for Distinguishing the Origin of Ellagic Acid Extracts: Pomegranate Peels or Gallnuts
Authors: Wei Jinchao , Xu Renjian , Zhang Yuanyuan , Zhao Lingyu , Li Shumu , Zhao Zhenwen
Published: January 2024

Ellagic acid, known for its various biological activities, is widely used. Ellagic acid from pomegranate peels is safe for consumption, while that from gallnuts is only suitable for external use. However, there is currently no effective method to confirm the source of ellagic acid. Therefore, this study establishes an analysis method using ultra-high-performance liquid chromatography–electrospray ionization–high-resolution mass spectrometry (UHPLC-ESI-HR-MS) to identify the components of crude ellagic acid extracts from pomegranate peels and gallnuts. The analysis revealed that there was a mix of components in the crude extracts, such as ellagic acid, palmitic acid, oleic acid, stearic acid, and 9(10)-EpODE. Furthermore, it could be observed that ellagic acid extracted from gallnuts contained toxic substances such as anacardic acid and ginkgolic acid (15:1). These components could be used to effectively distinguish the origin of ellagic acid from pomegranate peels or gallnuts. Additionally, a rapid quantitative analysis method using UHPLC-ESI-MS with multiple reaction monitoring (MRM) mode was developed for the quality control of ellagic acid products, by quantifying anacardic acid and ginkgolic acid (15:1). It was found that one of three ellagic acid health care products contained ginkgolic acid (C15:1) and anacardic acid at more than 1 ppm.
Numerical Study of Hydrodynamic Cavitation Pretreatment of Food Waste: Effect of Pressure Drop on the Cavitation Behavior
Authors: Zhou Peng , Zhong Ke , Zhu Yanbin
Published: January 2024

Hydrodynamic cavitation (HC) has a wide range of application scenarios. However, there are few studies on the HC treatment of food waste (FW). A Venturi device is designed and operated and plays a clear role in changing the characteristics of FW. The medium viscosity is often neglected when studying cavitation behavior by numerical simulations. We use the Herschel–Bulkley model to describe the viscosity curves of artificial FW samples obtained experimentally. RANS numerical simulation is carried out with a simplified 2D axisymmetric CFD-based model considering the non-Newtonian fluid properties. A numerical simulation study is carried out for FW (TS = 10.0 wt%) at pressure drop (ΔP = 0.05–0.4 MPa). The numerical simulation results show the variation of flow characteristics, viscosity, vapor volume, turbulent viscosity ratio, cavitation number, and pressure loss coefficient. With the increase in ΔP, the flow rate in the Venturi throat increases, and the average viscosity decreases. It reduces the inhibition effect of viscosity on cavitation. The position of incipient vacuoles at the moment of cavitation is constant and unrelated to the variation of ΔP. Under the effect of increasing ΔP, the average vapor volume fraction is increased, and the cavitation effect is enhanced; the cavitation number (σ) is decreased, and the cavitation potential is improved. A larger ΔP should be selected to increase the cavitation efficiency E of the device.
Automation of accounting support for settlements with the personnel of an agricultural organization when applying a piecework payment system
Authors:   Federal State Budgetary Educational Institution of Higher Education Stavropol State Agrarian University, Stavropol, Russia, Kostyukova E. I. , Bobryshev A. N. ,   Federal State Budgetary Educational Institution of Higher Education Stavropol State Agrarian University, Stavropol, Russia, Germanova V. S. ,   Federal State Budgetary Educational Institution of Higher Education Stavropol State Agrarian University, Stavropol, Russia, Frolov A. V. ,   Federal State Budgetary Educational Institution of Higher Education Stavropol State Agrarian University, Stavropol, Russia, Khoruzhy V. I. ,   Financial University under the Government of the Russian Federation, Moscow, Russia
Published: January 2024

In the process of reforming the accounting system in the Russian Federation, changes also concerned sectoral accounting, which is particularly characteristic of accounting in agriculture. Along with this, the production-technological and organizational- legal features of the agro-industrial sector determine the need for a differentiated approach to these transformations. In crop production, costs accumulate unevenly over a long time, and their compensation depends on the natural conditions of plant maturation. Since agriculture is characterized by seasonality of production, the main problem of accounting for mutual settlements with the organization’s personnel is the uneven distribution of labor and labor costs. In this regard, the payment of wages is carried out during periods when the final results of activities have not yet been received, in connection with which there is an increase in the actual cost of production, which, in the end, may not be received. The subject of the study is the accounting and analytical aspects of settlements with personnel in terms of determining the labor participation of personnel of an agricultural organization in the application of a piecework wage system. The information base was the forms of accounting and tax reporting of agricultural organizations of the Stavropol Territory. The scientific novelty of the research consists in the development and implementation of various accounting and analytical aspects of settlements with personnel in terms of determining everyone’s labor participation.