bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Fermentation Process and Sensory Acceptability of Traditional Banana Beer (Urwagwa) Using a Bioprocess method
Authors: Uzabakiriho Thierry , Osinachi Uzodinma Eunice Uche
Published: November 2023

This research study was conducted to optimize the fermentation process and sensory acceptability of traditional banana beer using Mixture design. Banana beer samples were produced from blends of banana juice, malted or non-malted sorghum, water, and hops. Saccharomyces Cerevisiae was used to ferment banana beers. Traditional banana beers were coded (S1, S2, S3) while improved banana beers (S4, S5,S6,S7,S8,S9,S10,S11, and S12) were produced by fermenting the mixture of banana juice under room temperature and pressure. The experimental design was based on Mixture I-optimal design using Design Expert software version 11.0. Experimental constraints were: 0.5≤A ≤0.9; 0.05≤ B ≤0.37; 0≤ C ≤0.05; 0≤ D ≤0.30, A, B, C and D represented banana juice’s brix, sorghum flour/malt, hops and water respectively. Produced samples were subjected to alcohol content, pH, methanol, Total Soluble Solid, Titratable Acidity (TA), Standard Reference Method (SRM) and sensory analyses. The alcohol content ranged from 3.75±1.06 - 6.12±0.70 % and the highest was obtained at the optimum pH of 4.15±0.07. The pH in all samples ranged from 3.53±0.14 - 4.78±0.05. Methanol content ranged from0.01±0.00 % to 0.76±0.02 %. Total Soluble Solid (TSS), TA, and SRM results were 2.00±0.00 - 24.00±2.82oBrix, 0.13±0.02 - 0.29±0.00%, and 6.08±0.24 - 12.14±0.52 respectively. Synergistically roasting, malting and mashing of sorghum significantly (p<0.05) helped to get the desired sensory characteristics of banana beers. Thus, the overall acceptability scores of traditional and improved banana beers ranged from 4.60±1.39 - 5.05±1.14 and 5.35±2.25 - 7.00±1.29 respectively.
Unpacking the hustles in illegal trade practices and control: evidences from the major contraband hotspots
Authors: Derege Alemayehu , Ahmed Abdi , Nagesso Kasahun
Published: November 2023

The increasing volume of illicit cross-border trades in the Horn of Africa, particularly in Ethiopia, has significant economic and social impacts. Regulatory measures to contain this issue face challenges, as many people in border areas rely on contraband trade and informal businesses for their livelihoods and access to essential goods. To shed light on this issue, this study examined contraband practices, the regulatory framework, and the socio-economic consequences in Oromia regional state. The study used both secondary and primary data, collected through a two-stage cluster sampling method, involving both private and public actors in illegal trade practices along major contraband corridors. Structural Equation Modeling (SEM) and logistic regression were applied to estimate latent theoretical constructs related to illegal trade activities and their inter-relationships. First, indices were estimated using SEM, and then the links between the obtained composite measures and key economic variables were estimated using logistic regression. The study findings reveal significant relationships between regulatory quality and illegality. A 10% increase in contraband trade corresponds to a 1.4% decrease in tax payment. The expansion of contraband trade from a lower to higher scale hampers local linkage development by 66 percentage points. Lack of coordination and collaboration among government structures and stakeholders is identified as a key issue. Addressing these gaps in the regulatory framework and fostering cooperation among governance structures are crucial for effective short and long-term solutions. Governments should take realistic actions, including collaboration with neighboring countries, to combat unregulated cross-border trade.
The Efficacy and Safety of Using Prophylactic Antibiotics Perioperative Laparoscopic Cholecystectomy; A Prospective Observational Cohort Study
Authors: Arnaout Ahmad Yamen , Atli Abd Alazeez , Nerabani Yaman , Hamdan Ola , Dabbagh Ezeddin , Alhejazi Tala Jouma , Kadoura Lama , Masri Ruqaya , Bsata Adel , Kayali Hasan , Mahli Nehad , Al-Haj Ahmad , Ayoub Kusay , Niazi Ammar , Ghazal Ahmad
Published: November 2023

Background: Antibiotic prophylaxis is recommended by many guidelines for laparoscopic cholecystectomy. However, the effectiveness and safety of this measure remain controversial due to the fact that most recommendations are based on old and low-quality evidence.
Methods: A total of 325 patients who underwent laparoscopic cholecystectomy at Aleppo University Hospital between February 1, 2022 and November 30, 2022 were involved in the study. Inclusion criteria included: laparoscopic cholecystectomy cases, aged between 18 and 90, and patients who accepted to participate in our study. While exclusion criteria included: open cholecystectomy.
Results: There was no significant difference in the difficulty of surgical work or perioperative medications between groups. Thirty Complications happened included Wound infection (N=12, PAG = 1, NAG =11; P =0.07), Urinary Tract Infection (N=4 , PAG = 1 , NAG =3 ;P=0.314), bleeding (N=2, PAG = 1, NAG =1; P=0.175), Acute pancreatitis (N=2, PAG = 1, NAG =1; P=0.175), prolonged shoulder pain (N= , PAG =0 , NAG =2 ;P=0.165), intra-abdominal abscess (N=1, PAG =0, NAG =1; P=0.198), Bile leak (N=1, PAG = 1, NAG =0; P=0.056), and other (N=8, PAG = 2, NAG =6; P=0.2). While no case of renal, respiratory (pneumonia), CVA, or Venous thromboembolism complication was recorded during the follow-up period for both groups. Thirteen patients required unplanned readmission and one death occurred in the antibiotic group. Only one case needed ICU care in the antibiotic group. There was a tendency for more complications in patients who did not receive antibiotics in most subgroups, but these results were not statistically significant and require further study with larger patient numbers to determine significance.
Conclusion: The medical literature is still unable to answer whether to use PA or not. We tried to cover all possible types of LC and follow them up for a sufficient period. However, future studies with larger samples are needed to solve the debate and improve the present guidelines.
Degradation of Rice Husks by Fungi Species Isolated from Rice Husk Dumps at Abakaliki
Authors: Onwa Ndubuisi Colins , Ozor Perpetua Ebele , Okon Michael Ben
Published: November 2023

Degradation of rice husks by fungi species isolated from old rice husk dumps at Abakaliki rice mill was carried out. Standard microbiological techniques were used in isolating and identifying the fungi species from the old rice husk dumps. The isolated fungi species were used to screen for their ability to degrade fresh rice husks by their ability to produce reducing sugars. The identified fungi isolates were then used to degrade fresh rice husks for five days. Also, the cellulase activities of the fungal species that degraded the rice husks were assessed for their ability to produce clear zones on carboxylmethylcellulose (CMC) agar. Results showed that ten species of fungi were isolated, out of which five were able to produce reducing sugars and were identified as Aspergilus flavus, Aspergillus niger, Aspergillus fumigatus, Rhizopus microsporus and Mucor pusillus. The result revealed that Mucor pusillus degraded the rice husks more by producing the highest reducing sugar value of 123.342 mg/l followed by Aspergilus flavus (116.551mg/l), Aspergillus fumigatus (96.731mg/l), Rhizopus microsporus (94.225mg/l) and Aspergillus niger (93.153mg/l). The highest reducing sugar production occurred on the 3rd and 4th days of degradation. With respect to cellulase activity, Mucor pusillus had the highest cellulase activity by producing the widest clear zone of 40.00mm on CMC agar while Aspergillus niger had the least cellulase activity by producing the smallest clear zone of 24.0mm in CMC agar. Therefore, the production of reducing sugars by these organisms showed that they can degrade rice husks.
Robust Visual SLAM in Dynamic Environment Based on Moving Detection and Segmentation
Authors: Yu Xin , Shen Rulin , Wu Kang , Lin Zhi
Published: November 2023

In this study, a robust and accurate SLAM method for dynamic environments is proposed. Sparse optical flow and epipolar geometric constraint are combined to conduct moving detection by judging whether a priori dynamic object is in motion. Semantic segmentation is combined with moving detection to perform dynamic keypoints removal by removing dynamic objects. The dynamic objects removal method is integrated into ORB-SLAM2, enabling robust, accurate localization and mapping. Experiments on TUM datasets show that compared with ORB-SLAM2, the proposed system can significantly reduce the pose estimation error, and the RMSE and S.D. of ORB-SLAM2 are reduced by up to 97.78% and 97.91% respectively under high dynamic sequences, improving the robustness in dynamic environments. Compared with other similar SLAM methods, the RMSE and S.D. of the proposed method are reduced by up to 69.26% and 73.03% respectively. Dense semantic maps built with our method are also much closer to the groundtruth.
Neutron Filter using Periodic Multilayers of Ferromagnetic and Paramagnetic Layers
Authors: Zaky Zaky A. , Al-Dossari M. , Zhaketov V. D. , Hendy Ahmed S. , Aly Arafa H.
Published: November 2023

Binary and ternary multilayers comprising paramagnetic and ferromagnetic materials filter out a specific neutron wavelength from the reflected broad spectrum. The effect of the grazing angle, the magnetization of the ferromagnetic layers and the scattering length density of the ferromagnetic layers for both structures are studied. The best performance of the proposed filter, such as the broadest neutron bandgap of 0.46 Å and the smallest bandwidth of the transmitted beam of 0.0016 Å, was achieved using the binary structure at magnetization of 40 kOe. These findings hold potential in the nuclear fields, including neutron waveguides and filters.
Trial number and sample size do not affect accuracy of the I2- point estimate for testing selection bias risk in meta-analyses. A simulation study (Preprint)
Authors: Mickenautsch Steffen , Yengopal Veerasamy
Published: November 2023

Objectives: To establish the test sensitivity and specificity of the I2-point estimate for testing selection bias in meta-analyses under condition of large versus small trial sample size and large versus small trial number in meta-analyses and to test the null-hypotheses that the differences are not statistically significant.
Methods: Simulation trials were generated in MS Excel, each consisting of a sequence of subject ID (accession) numbers representing trial subjects; a random sequence of allocation to group A or B and a random sequence of a simulated baseline variable (‘age’) per subject, ranging between 50 to 55. These simulation trials were included into five types of meta-analyses with large/small numbers of trials, as well as trials with large and small sample sizes. Half of the meta-analyses were artificially biased. All meta-analyses were tested using the I2 point estimate. The numbers of true positive, false positive, false negative and true negative test results were established. From these, the test sensitivity and specificity were computed for each of the meta-analysis types and compared.
Results: All non-biased meta-analyses yielded true negative and all biased meta-analyses true positive test results, regardless of trial number and trial sample size. No false positive or false negative test results were observed. Accordingly, test sensitivities and specificities of 100% for all meta-analysis types were established and thus both null-hypotheses failed to be rejected.
Conclusion: The results suggest that trial number and sample size in a baseline variable meta-analysis do not affect the test accuracy of the I2-point estimate.
The challenge of diagnosing lumbar segmental instability
Authors: Hipp John A. , Reitman Charles A. , Chaput Christopher D. , Buser Zorica , Grieco Trevor F.
Published: November 2023

Background Lumbar spinal instability is very commonly discussed in research studies and is routinely used in clinical practice to make treatment decisions. That practice must be reconciled with expert consensus in the peer-reviewed literature: there is currently no validated diagnostic test for spinal instability. Some treatments for instability can have serious complications, so correct diagnosis is important. Biomechanically rational and clinically effective diagnostic tests for instability are needed, where instability is defined as incompetence of the intervertebral motion restraints forming the passive part of the motion control system.Methods This study critically examines and identifies deficiencies in previously employed metrics and criteria for diagnosing spinal instability. New metrics are described that account for the deficiencies. The new metrics were retrospectively applied to 7621 lumbar spine flexion-extension studies to document the prevalence of abnormalities in different patient populations.Results Traditional measurements, such as intervertebral rotation or translation, may fail to find abnormalities in intervertebral motion due to factors such as inconsistent patient effort and radiographic magnification. The proposed biomechanically grounded metrics for lumbar spine sagittal plane shear and vertical instability appear more adept at finding abnormalities in patient populations where abnormalities might be expected and not in patients where instability would not be expected.Discussion New approaches to detecting abnormal sagittal plane intervertebral motion may lead to enhanced and standardized diagnosis of lumbar spine instability. Further clinical research is imperative to validate the efficacy of these metrics in diagnosis and treatment algorithms.
Mpox, STIs, and HIV in the LGBTQIA2S+ Community: What can be learned from bibliometric analysis?
Authors: Adnyana I Made Dwi Mertha
Published: November 2023

The LGBTQIA2S + community is vulnerable to health problems, including triple-burden diseases such as Mpox, sexually transmitted infections (STIs), and HIV positivity. This zoonotic disease is a global health burden in nonendemic countries. With increasing cases of the three diseases, this community faces various threats, obstacles, and challenges. This review aimed to identify the threats and barriers to triple-burden disease, including mpox infection, STIs, and HIV infection, simultaneously in LGBTQIA2S + populations. A bibliometric study approach was used to map these three diseases' research journeys and findings worldwide. The LGBTQIA2S + community faced distinct health disparities, including the triple disease burden, which refers to the higher prevalence and impact of multiple health conditions in this group. Although there has been no specific research on the triple burden of Mpox, STIs, and HIV in the LGBTQIA2S + community, this population faces various direct and indirect threats and barriers. These include stigma, discrimination, a lack of culturally competent care, limited resource access, and mental health effects. A comprehensive approach that includes destigmatization efforts, education, accessible healthcare services, and mental health support is necessary to address these challenges and improve the LGBTQIA2S + community's overall health outcomes. Promoting inclusivity, understanding, and awareness is essential to reduce community barriers and improve health.
An observational study to assess effectiveness of POSSUM and P-POSSUM score for prediction of morbidity and mortality after surgery for ileal perforation
Authors: Bhat Durgesh , Katkade Shivaji
Published: November 2023

Background: Perforative peritonitis is the most common surgical emergency. Most common perforation is seen in ileum, followed by duodenum, stomach, appendix, jejunum and colon. The methods of source control for ileal perforations include primary closure, resection, and anastomosis of small gut or diverting stoma, depending on the site and number of perforations, severity of peritonitis, and general condition of the patient. This study aims to assess the effectiveness of the POSSUM and P-POSSUM score in predicting morbidity and mortality following surgery for ileal perforation. And evaluate the correlation between the physiological factors and operative findings leading to morbidity and mortality for ileal perforation.
Method: The study included all cases of ileal perforation undergoing surgery. Predicted morbidity and mortality scores were calculated based on physiologic and Operatives cores using POSSUM & P-POSSUM equations.
Result: A total 40 patients were included in present study. Mean POSSUM morbidity was 95.45, while mean POSSUM mortality was 69.28. Significant association was found between physiological and operative score with fair correlation. Expected morbidity and mortality determined by POSSUM score showed values significantly above the observed ones. P-POSSUM score systems was effective in predicting mortality.
Conclusion: POSSUM and P-POSSUM score can be used as good stratification tool for predicting morbidity and mortality in cases of ileal perforation respectively.
A Study on the Differential Effects of Heterogeneous Environmental Regulations on the Green Transformation of Chinese Manufacturing Enterprises under "Double Carbon" Target
Authors: Tang Yongjun , Qi Yuqiu , Zhou Fen , Hua Lei
Published: November 2023

Using panel data of Chinese manufacturing enterprises listed in Shanghai and Shenzhen A-shares from 2015 to 2021, we examine the effects of heterogeneous environmental regulations on the green transformation of Chinese manufacturing enterprises under "Double Carbon" target, and reveal the mediating role played by managers' green perception in the process from an intra-firm perspective. We find that three environmental regulation tools, namely environmental administrative supervision, environmental economic regulation and environmental soft constraint, all contribute significantly to the green transformation of manufacturing enterprises. Among them, environmental economic regulation is the most effective in promoting the green transformation of manufacturing enterprises, followed by environmental soft constraint and environmental administrative supervision. The mechanism analysis shows that managers' green perception is partially mediated between heterogeneous environmental regulations and the green transformation of manufacturing enterprises. Moreover, environmental administrative supervision is the most effective in raising managers' green perception among them, followed by environmental economic regulation and environmental soft constraint. Further analysis shows that the positive effect of heterogeneous environmental regulations on the green transformation of Chinese manufacturing enterprises is more significant when the enterprises locate in regions with high policy uncertainty, in the eastern part of the country, or when the enterprises are state-owned enterprises. The conclusions provide a theoretical basis for Chinese environmental policymakers to flexibly adopt differentiated environmental regulation tools.
The Relationship Between Frailty and Schizophrenia: A Genetic Association and Mendelian Randomization Study
Authors: Deng Ming-Gang , Wang Kai , Liu Fang , Zhou Xiuxiu , Liu Jiewei
Published: November 2023

Importance Frailty was associated with elevated risks of various diseases and could induce many adverse outcomes in schizophrenia patients. However, the association and causality between frailty and schizophrenia are still unclear.Objective To investigate the genetic association and causality between frailty and schizophrenia.Design, Setting, and Participants We obtained the summary genetic data related to frailty and schizophrenia from the large-scale genome-wide association studies in the European population. Genetic association analyses were investigated from 5 aspects: global genetic correlation, local genetic correlation, shared genomic loci, overlapped tissue enrichments, and shared functional genes. The causality was inferred via the bidirectional Mendelian Randomization (MR) analyses.Main Outcomes and Measures The genetic association and causality between frailty and schizophrenia.Results The global genetic correlation analyses presented they were positively associated, and the local genetic correlation analyses demonstrated they were locally correlated in three genomes. Furthermore, 111 genomic loci were found to be jointly associated with frailty and schizophrenia. Additionally, the tissue enrichment and summary-data-based MR analyses demonstrated the genetic variants related to frailty and schizophrenia have overlapped tissue enrichments and functional genes in the brain. Lastly, the MR results implied there was a bidirectional causal relationship between frailty and schizophrenia.Conclusions and Relevance Our study indicated that frailty and schizophrenia had plenty of shared genetic basis and supported their bidirectional causality. Further studies are warranted to validate these findings in non-European populations.
Kommasetzung in Texten von Grundschulkindern
Authors: Betzel Dirk
Published: November 2023

Der Beitrag stellt Ergebnisse zur Kommasetzung von Kindern aus vierten Klassen vor und beleuchtet damit ein von kommadidaktischen Einflüssen weitgehend unabhängiges Können. Unter Berücksichtigung verschiedener Kommatypen sowie einschlägiger Kontextmerkmale wurden rund 1000 frei verfasste Texte ausgewertet, die in den Jahren 1972, 2002 und 2012 unter ähnlichen Erhebungsbedingungen entstanden sind. Ziel ist es, die Kommasetzung in Texten von Grundschulkindern möglichst differenziert zu beschreiben, um abschließend die Frage aufzugreifen, inwieweit eine Kommadidaktik für die Grundschule angemessen erscheint. Auffällige Veränderungen zwischen den Gruppen in einem Zeitraum von 40 Jahren werden ergänzend betrachtet. Im Ergebnis zeigt sich zu allen Erhebungszeitpunkten bei einem Teil der Kinder ein beachtliches Können, wenngleich der prozentuale Anteil der Kommasetzer/-innen geringer als in vergleichbaren Untersuchungen ausfällt.
Influence of Soil and Nutrient Management Practices on Crop Productivity and Quality in High Tunnel Organic Leafy Green Production
Authors: Tian Shufang , Brecht Jeffrey K. , Rathinasabapathi Bala , Zhao Xin
Published: November 2023

Despite the growing interest in high tunnel organic vegetable production, limited information is available regarding optimizing nutrient management for organic leafy greens. This 3-year study examined the impacts of cowpea cover crop as well as different organic fertilizers and composts on yield, leaf mineral nutrient content, and phytochemical properties of organic leafy greens produced in high tunnels under Florida sandy soil conditions. The experiment was arranged in a split-split-plot design with three replications. The whole plots consisted of a cowpea (Vigna unguiculata ‘Iron & Clay’) cover crop and a weedy fallow control, with fertilization treatments in the subplots, including preplant application of granular fertilizer vs. weekly injection of liquid fish fertilizer at the same seasonal rates of nitrogen (112 kg/ha), phosphorus (9.8 kg/ha), and potassium (74.4 kg/ha). The sub-subplots included yard waste-based compost (22.4 Mt/ha), cow manure-based compost (22.4 Mt/ha), vermicompost (5.6 Mt/ha), and no compost control. Cowpea was broadcasted (112 kg/ha) in early July or mid-August and terminated 51 to 53 days after seeding. Pac choi (Brassica rapa var. chinensis ‘Mei Qing Choi’) was transplanted in mid-Sep. or mid-Oct. and harvested after 33 to 36 days. Baby spinach (Spinacia oleracea ‘Corvair’) or baby leaf lettuce (Lactuca sativa ‘Outredgeous’) was direct seeded subsequently as a catch crop. Each experimental unit remained in the same location across the 3 years of the study. Cover cropping had little influence on yields, leaf mineral nutrients, ascorbic acid content, total phenolics, and total antioxidant capacity of pac choi and baby spinach/lettuce. Compared with preplant application of the granular organic fertilizer, weekly liquid organic fertigation improved pac choi marketable yield and dry weight by 16.8% and 5.4% on average, respectively, and enhanced leaf nitrogen and phosphorus contents on a dry weight basis. Relative to the no compost control, yard waste compost consistently improved marketable yields of pac choi by 11.6% on average and led to higher yields of the baby spinach/lettuce catch crop in years 1 and 3, suggesting that compost applications may enhance seasonal nutrient availability to better meet crop demand. However, compost application exhibited inconsistent effects on crop mineral nutrient and phytochemical contents across the years, which could be attributed to the different nutrient compositions of the composts applied in each season, as well as the legacy effects from the previous season. Furthermore, the compost benefits may be influenced by the fertilization program as indicated by their interaction effects observed in this study.
Chlorophyll Fluorescence Parameter as a Tool in Selecting Heat-tolerant Summer-flowering Chrysanthemum (Dendranthema ×grandiflorum)
Authors: Yu Jun-Yao , Chen Chin-Mu
Published: November 2023

Chrysanthemum ‘Bai Tian Xing’, ‘Huang Ching Chin’, ‘Pink Pearl’, and ‘NCHU-001’ plants were preheated at 35 °C for 24 hours to induce heat tolerance. The recently fully expanded leaves were detached, kept in a moist Ziploc bag, and then subjected to 35, 40, 45, 47.5, 50, 52.5, 55, 60, or 65 °C for 20 minutes. After dark-acclimatized at room temperature for 30 minutes, leaves were measured for Fv/Fm value with a chlorophyll fluorescence parameter. Results showed that ‘Bai Tian Xing’ had the highest critical (Tcrit) and midpoint temperature (Tmid). Mean Tcrit and Tmid were shown to be 47 and 50 °C, respectively, and Tmid gave greater distinguishment of Fv/Fm value among cultivars. Plants of four cultivars were acclimatized at 15 to 40 °C for 3 days and 35 °C being the most effective temperature to induce a heat-tolerant response in chrysanthemum. Required inducing time to reach a stable leaf Fv/Fm value ranged from 4.6 to 11.1 hours among cultivars. All cultivars had similar required time to reach visible bud between summer and autumn crops (except NCHU-001), but all had delayed flowering in the summer crop. There is a negative linear relationship between flowering heat delay and leaf Fv/Fm value (R2 = 0.93). Progenies from reciprocal crossing of ‘Bai Tian Xing’ × ‘NCHU-001’ and ‘Huang Ching Chin’ × ‘Pink Pearl’ were also subjected to treatments for Fv/Fm measurements and observed for time to flowering in the summer crop. All combinations showed negative linear relationship between time to flowering and leaf Fv/Fm value (R2 = 0.70–0.87). Two plants, 109-W001Y and 109-W003Pi, showed early flowering habit and good flower performance under heat conditions were selected. All four cultivars and the two selected lines were measured for photosynthetic parameters under day/night temperatures of 35/30 or 25/20 °C in growth chambers. All cultivars and lines showed decreased net photosynthetic rate and dark respiration rate under 35/30 °C when compared with 25/20 °C. Relatively higher net photosynthetic rate and lower dark respiration rate in ‘Bai Tian Xing’, ‘109-W001Y’, and ‘109-W003Pi’ under 35/30 °C, when compared with the other three cultivars, might have contributed to better flowering performance in the summer.
O CICLO DE VIDA PROFISSIONAL: UM ESTUDO COM PROFESSORES DA ETEJLN – FAETEC
Authors: Coutinho Ana Paula , Barbosa Moreira Antonio Flavio
Published: November 2023

Esta pesquisa se propôs a abordar o ciclo de vida profissional dos professores, em especial, os professores de uma escola técnica, pertencente a uma rede, no caso a FAETEC, nos levando a refletir sobre a formação e o trabalho docente. A formação inicial e continuada, o tempo de atuação, a formação específica e suas relações com a escola e a tarefa docente, tão específica de um curso que forma profissionais para o mercado de trabalho. Em que fases da carreira docente se encontram os professores da Escola Técnica Estadual João Luiz do Nascimento – ETEJLN – da rede Fundação de Apoio à Escola Técnica – FAETEC? Os resultados demonstraram em que fase esses professores se encontram na carreira docente, sob a análise dos parâmetros de Huberman (2007). As fases estudadas são: entrada, fase da estabilização, fase da diversificação e continuidade na carreira, serenidade, distanciamento afetivo e conservadorismo e o desinvestimento. A metodologia aplicada foi estudo de caso, com aplicação de entrevista estruturada contendo questões objetivas e discursivas, realizada pelo Google Formulário, aos docentes do Ensino Técnico e Médio. Os resultados, após análise, revelaram que a maioria dos professores se encontra na fase da Diversificação, bem como da Serenidade e Distanciamento, pelas características levantadas. O estudo verificou o modo como ocorre a formação e o trabalho dos professores, por meio da formação inicial e continuada, e possibilitou categorizar, por suas falas, os momentos em que se encontram em suas carreiras profissionais, em tempos de grandes desafios docentes. Destacou-se a importância da análise da trajetória profissional dos professores da ETEJLN, as formas como cada professor se percebe nesse processo de autorreflexão. Diante do exposto, o estudo do ciclo da vida profissional dos professores, com seus perfis — tipo, sequências e fases — levantou traços comuns nas trajetórias diversas que têm em comum a escola onde atuam.
Towards Customer Satisfaction: The Role of Customer Relationship Management, Service Quality, and Customer Perceptions
Authors: Bupu Roswita , Sodikin Mohamad , Sanchita Sanchita
Published: November 2023

Orientation and focus on customer satisfaction is an important part of efforts to improve sustainable organizational performance. The Customer Relationship Management (CRM) strategy is part of an effort to find, collect, store information about customers and implement it in all parts of the organization so as to provide a unique experience for customers. However, most of the previous studies have focused on the effect of CRM on companies and few have reviewed CRM in the context of customer perceptions. Drawing based on congruity theory, this study aims to examine the effect of CRM on customer satisfaction through the mediating role of customer perceptions and service quality. Through random sampling, 87 data were obtained from customers who used the services of PT Jasco Logistics Semarang. Data was obtained using a questionnaire with the consent of the respondents. Then analyzed using Partial Least Square (PLS) with the Smart PLS 3.0 program application. The results of this study indicate that Customer Relationship Management (CRM) indirectly has a significant influence on customer satisfaction through service quality and perceived customer perceptions. It was also found that customer perception and service quality directly contribute significantly to customer satisfaction. However, service quality has a greater influence through customer perceptions. These findings provide significant insight for practitioners that in building a CRM strategy it must be able to provide a unique and valuable experience that is felt by customers, so that this will trigger satisfaction.
Targeted Polymeric Nanoparticles as a Strategy for the Treatment of
Glioblastoma: A Review
Authors: de Paula Geanne Aparecida , de Paula Mariana Carlomagno , Dutra Jessyca Aparecida Paes , Carvalho Suzana Gonçalves , Di Filippo Leonardo Delello , Oliveira Villanova Janaína Cecília , Chorilli Marlus
Published: November 2023

Glioblastoma multiforme is the most common and aggressive malignant tumor that affects
the central nervous system, with high mortality and low survival. Glioblastoma multiforme treatment
includes resection tumor surgery, followed by radiotherapy and chemotherapy adjuvants. However,
the drugs used in chemotherapy present some limitations, such as the difficulty of crossing the bloodbrain barrier and resisting the cellular mechanisms of drug efflux. The use of polymeric nanoparticles
has proven to be an effective alternative to circumvent such limitations, as it allows the exploration
of a range of polymeric structures that can be modified in order to control the biodistribution and
cytotoxic effect of the drug delivery systems. Nanoparticles are nanometric in size and allow the
incorporation of targeting ligands on their surface, favoring the transposition of the blood-brain barrier and the delivery of the drug to specific sites, increasing the selectivity and safety of chemotherapy.
The present review has described the characteristics of chitosan, poly(vinyl alcohol), poly(lactic-coglycolic acid), poly(ethylene glycol), poly(β-amino ester), and poly(ε-caprolactone), which are some
of the most commonly used polymers in the manufacture of nanoparticles for the treatment of glioblastoma multiforme. In addition, some of the main targeting ligands used in these nanosystems are
presented, such as transferrin, chlorotoxin, albumin, epidermal growth factor, and epidermal growth
factor receptor blockers, explored for the active targeting of antiglioblastoma agents.
Recent Advances in Enzyme Inhibition: A Pharmacological Review
Authors: Singh Kuldeep , Bhushan Bharat , Mittal Nidhi , Kushwaha Abhishek , Raikwar Chandan Kumar , Sharma Arun Kumar , Chanchal Dilip Kumar , Kumar Shivendra , Agrawal Mohit
Published: November 2023

Enzyme inhibition is a crucial mechanism for regulating biological processes and developing therapeutic interventions. This pharmacological review summarizes recent advances in enzyme inhibition, focusing on key developments and their implications for drug discovery and therapeutic strategies. It explains basic ideas, including the different kinds of inhibitors and how they work, and looks
at recent advances in small-molecule inhibitor design, fragment-based drug discovery, and virtual
screening techniques. The review also highlights the advances in targeting specific enzyme families,
explaining the structural basis of enzyme-inhibitor interactions, optimizing inhibitor potency, selectivity, and pharmacokinetic properties, and new trends in enzyme inhibition. The clinical implications of
recent advances in enzyme inhibition include the development of novel therapeutic agents for diseases
like cancer, infectious diseases, and neurological disorders. The review addresses challenges and future
directions in the field, such as optimizing drug safety, resistance mechanisms, and personalized medicine approaches. Overall, the insights provided in this review may inspire further research and collaborations to accelerate the translation of enzyme inhibitors into effective clinical treatments.
Linking Career Anxiety with Suicide Tendencies among University Undergraduates
Authors: Onyishi Charity N.
Published: November 2023

Background:

Suicide is increasingly becoming a worldwide public health issue. The issue of suicide in universities is one of the most pressing concerns in Nigeria and the world. Yet, it has not been clear the factors that account for increased suicide among university students. This study investigated the link between career anxiety and suicidal tendencies among university undergraduates.

Methods:

The study was cross-sectional correlational and used a sample of 3,501 undergraduates in Nigeria. Career anxiety was measured using the two-factor career anxiety scale (CAS -2). At the same time, suicide tendencies were weighed using the Multi-attitude Suicide Tendency Scale (MAST), and Suicidal Ideation Attributes Scales (SIDAS).

Results:

Data collected were analyzed using percentages to interpret demographic data. Mean and standard deviation was presented for descriptive purposes. Linear regression was used to explore the links between career anxiety and suicidal tendencies at p < 0.05 level of significance. Results indicated that a high level of career anxiety was significantly correlated with increased suicidal tendencies, such as repulsion for life, attraction to death, and suicidal ideation. A low level of career anxiety was associated with decreased suicidal tendencies, characterized by an increased attitude toward attraction to life and repulsion to death.

Conclusion:

It was concluded that students with problematic career anxiety are likely to report a negative attitude toward life, which leads to increased suicidal ideation. Accordingly, career anxiety may cause one to seriously consider or contemplate suicide.
Soil Inhabitant Bacteria: Morphology, Life Cycle and Importance in Agriculture and Other Industries
Authors: Qamar Safi Ur Rehman , Calma Mayer L.
Published: November 2023

There are many bacteria in the soil, but they have less biomass because of
their small size. Soil-inhabitant bacteria are an essential source of nutrients for plants.
Some studies highlighted their industrial importance, like in the pharmaceutical
industry, perfume manufacturing, and agriculture product scale-up production,
including biofertilizers. Most of the studies have been carried out on Actinobacteria
and Nitrobacter because of their potential to produce biofertilizers and chemical
constituents on a large scale. This chapter discussed their taxonomic and morphological
characteristics and gathered details about their practical applications from limited
studies carried out in this field.
The Effect of Diversity Management on Employee Engagement in the Manufacturing Sector
Authors: Afif Ali Amran Al
Published: November 2023

In Indonesia's manufacturing industry, which employs the third-largest workforce in the country, employee engagement is a critical measure of labor's contribution. Despite the industry's importance, diversity management—a key driver of engagement—lags, with low representation of women and persons with disabilities and persistent ethnic and racial discrimination in a nation known for its multiculturalism. Additionally, ageism is prevalent, manifesting as discrimination across different age groups. This study investigates the influence of four principal dimensions of diversity management—ethnic, gender, disability, and age—on employee engagement within the sector. Conducted as a field study in a manufacturing industry in Cilegon with 218 participants, the research provides insightful findings. Notably, it identifies age diversity management as the sole dimension with a significant impact on employee engagement, while the other three—ethnic, gender, and disability diversity management—do not show a substantial effect.
Assistive Technology Construction in Fulfilling the Rights of Telecommunication Information for Disabled People in Indonesia
Authors: Yani Ahmad , Julhijah Ratu , Muliana Muliana
Published: November 2023

The problem of accessibility to information and technology for people with disabilities in Indonesia is one of the state's responsibilities that must be implemented comprehensively. This study aims to determine the state's responsibility in fulfilling disability rights to information and telecommunications in Indonesia and aims to construct the ideal form of fulfillment of disability rights to information and telecommunications through assistive technology models. The research uses a normative-empirical method with a conceptual approach, a statutory approach, and a case approach. The results of the study show: First, the state's responsibility for protecting the rights of persons with disabilities to information and technology has been regulated in Article 28 F of the 1945 Constitution of the Republic of Indonesia and in Law Number 8 of 2016 concerning Persons with Disabilities as many as 13 (thirteen) articles. The regulation contains 8 (eight) substances for regulating the right to information for persons with disabilities. The implementation of these provisions has not run optimally because there are still services that are not friendly to persons with disabilities. Second, efforts to encourage the formation of assistive technology for people with disabilities in the country by referring to the needs of people with disabilities in Indonesia. This can be done by establishing two types of assistive technology for persons with disabilities of school age and above school age by adjusting features and services that are friendly to disabilities.
In silico Pharmacokinetic and Toxicity Prediction of Compounds from Andrographis paniculata (Burm.f.) Nees.
Authors: Izatunnafis Izatunnafis , Murti Yosi Bayu , Ari Sudarmanto Bambang Sulistyo
Published: November 2023

Many compounds have been isolated from Andrographis paniculata (Burm. f.) Nees (AP). In drug discovery and development, plant secondary metabolites are popular as resources for drug candidates. A high-quality drug candidate should not only be effective against the therapeutic target, but it should also be safe and have good pharmacokinetic features. This study aimed to predict the pharmacokinetic features and toxicity potencies of 46 compounds from AP using the pKCSM online tool. According to pKCSM prediction, among the forty-six compounds from AP, compound 1 (14-Deoxy-11,12-didehydroandrographolide), compound 2 (14-Deoxyandrographolide), and compound 39 ((-)-beta-Sitosterol) have good pharmacokinetic features and do not have potencies to be mutagenic and hepatotoxic agents. The lethal dosage values (LD50) of compounds 1, 2, and 39, are 1935, 2053, and 2424 (mol/kg), respectively. However, further research is still needed to confirm these predictions.
Ghosteo epistémico: el borramiento del activismo feminista a través de su institucionalización y mercantilización en el activismo menstrual argentino
Authors: Suárez Tomé Danila
Published: November 2023

En este artículo proponemos el concepto de ghosteo epistémico para dar cuenta de los problemas surgidos en la articulación entre la campaña de activismo menstrual #MenstruAcción, el Estado y las empresas que comercializan productos de gestión menstrual en Argentina. La hipótesis que buscamos probar es que esta articulación no fue lo suficientemente virtuosa como para reconocer y aprovechar plenamente el conocimiento que las activistas desarrollaron en el marco de la campaña en beneficio de la población menstruante, ni para resguardar su carácter emancipatorio. En el artículo se define el fenómeno del ghosteo epistémico como la apropiación del conocimiento y el discurso simbólico producidos por el activismo y su posterior borramiento, y se lo muestra funcionando tanto en la institucionalización como en la mercantilización del activismo menstrual argentino. El propósito final es que el concepto pueda ser reapropiado en otros contextos para su detección y solución.
Efficient CAD Systems for Automated Detection of Breast Cancer Malignancy: An Overview of Recent Advancements
Authors: Joseph Ardra Mariya , M Grace John , Dhas Anto Sahaya
Published: November 2023

Abstract: Computer- Aided Diagnosis (CAD) systems have importance in medical field since it helps to diagnose and detect many deadly diseases in its primary stages. Breast cancer is considered as one of the major causes of non-accidental death in women worldwide. Early detection and diagnosis of the disease let the doctor to administer suitable treatment, and can improve the patient’s chances of survival. Many researches were conducted for early detection of breast cancer. This review aims at providing an outline concerning recent advances and developments of CAD systems for mammogram interpretation in breast cancer analysis, pointing to act as a primer for specialists and scholars in the field. The paper investigates studies of many researchers in this field and briefly explained all the methods they have adapted in every stages of their works. This work can be utilize to study existing efficient techniques and help to develop more versatile CAD system for the detection of breast cancer.
An Unfinished War: The Historiography of the Organisation of Ukrainian Nationalists and the Ukrainian Insurgent Army Problems
Authors:   Taras Shevchenko National University of Kyiv, Patryliak Ivan , Pahiria Oleksandr
Published: November 2023

The  article analyses the  historiographical process related to the  history of Ukrainian nationalism, namely the  activities of the  Organisation of Ukrainian Nationalists and the Ukrainian Insurgent Army in the 1930s–1950s. Drawing on the chronological-terri-torial and conceptual-methodological principles, the authors divide the secondary sources into five main groups: writings by authors of the Ukrainian diaspora, works of Soviet scientists and publicists, post-independence Ukrainian historiography, communist and contemporary Polish historiography, Western history writing. Within each group, key publications are examined through the prism of documentary sources, methodologies, and conceptual approaches, as well as the socio-political context in which they were created.
Bruņotā pretošanās kustība padomju okupētajā Latvijā
Authors:   LU Latvijas vēstures institūts, Neiburgs Uldis  , Bruņinieks Haralds , Ratnieks Reinis , Vasiļevskis Jānis  , Viļums Jānis , Turčinskis Zigmārs  ,   Latvijas Universitāte
Published: November 2023

2023. gada 13. maijā Nacionālās pretošanās kustības muzejā Rendā notika vēsturnieku diskusija “Latvijas nacionālie partizāni: izpētes stāvoklis, problēmas un izaicinājumi”. Tajā piedalījās Daugavpils Universitātes Humanitārās fakultātes doktorants Haralds Bruņinieks, Latvijas Universitātes (LU) Vēstures un filozofijas fakultātes doktora grāda pre-tendents Reinis Ratnieks, bijušais Totalitārisma seku dokumentēšanas centra (TSDC) darbinieks Jānis Vasiļevskis, Mg. hist. Jānis Viļums un Mg. hist. Zigmārs Turčinskis. Diskusiju vadīja LU Latvijas vēstures institūta vadošais pētnieks Dr. hist. Uldis Neiburgs.
Sobre o desenvolvimento do ecossistema digital no domínio da educação e da ciência
Authors: Trusij Оksana , Parzhnytskyi Viktor , Shabala Yuliia , Lukіianchuk Alla , Stovba Tetyana
Published: November 2023

O objetivo da investigação é destacar os componentes estruturais, organizacionais, mentais e ideológicas do ecossistema digital do espaço educativo e científico. A tarefa do estudo é analisar a integração do potencial digital do sistema educativo. A metodologia utilizada no artigo baseia-se em abordagens metodológicas científicas gerais, principalmente analíticas. Os princípios sinérgicos e interdisciplinares pretendem fundamentar a influência mútua das ferramentas digitais e das diretrizes educativas e científicas. Os resultados do estudo indicam a necessidade de um novo posicionamento do elemento TIC como um elemento de pleno direito do ambiente educativo e científico. As tendências digitais modernas estão passando do status de inovação e popularização para o formato de aplicação prática na educação e na ciência. Assim, o ecossistema digital está ganhando o status de componente fundamental da esfera educativa e científica, assegurando o dinamismo, a mobilidade e o pragmatismo.