bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of opinions and philosophy of Jean-Jacques Rousseau in medical education
Authors: Moradi E , Ramazani Gh
Published: November 2023

The Article Abstract is not available.
Effects of Sglt2 Inhibitors on The Heart
Authors: ABDELBAKI M. , Baghous H.
Published: November 2023

Cardiovascular disease and type 2 diabetes are prevalent throughout the world and represent a real public health problem. The prevalence of T2DM ranges from 6.9% to 10.2% in developed countries and more than 7% in developing countries.
Cine actual y representación queer: la heteronormativa fórmula de la industria cinematográfica
Authors: Huaroc Cabrera Valentina
Published: November 2023

El cine es una forma de expresión artística que cuenta con un impacto significativo sobre la sociedad, lo cual implica que esta no se limita al entretenimiento, sino que su contenido tiene también una gran relevancia en las percepciones de los individuos. Así, a partir de las producciones cinematográficas se han abordado temas como el racismo, clasismo, machismo, entre otros. En particular, en el presente ensayo se abordarán las representaciones de la comunidad LGBTIQ+, la cual ha contado con cada vez más personajes relevantes en la pantalla; lo cual, aunque pareciera un avance importante en la aceptación de la comunidad, oculta estigmatizaciones aún latentes. En ese sentido, el presente ensayo tuvo como objetivo demostrar que las representaciones LGBTIQ+ en películas y series del siglo XXI, en su mayoría, son denigrantes e inapropiadas debido a que han sido construidas desde la heteronorma. Para sustentar esta afirmación se estudiaron los arquetipos presentes en el cine que construye personajes queer y se demostró su condición de afianzadores de estereotipos. De esta forma, se evidencian técnicas dentro de la industria del cine que impide una inclusión plena en respeto de las identidades sexuales.
La élite empresarial y la formación de la hegemonía neoliberal del Perú desde una perspectiva gramsciana
Authors: Macedo Antonio
Published: November 2023

El presente trabajo se enfoca en la configuración de actores y en el componente discursivo del paradigma neoliberal, y analiza, en particular, a partir del enfoque gramsciano de análisis de relaciones de fuerzas, el rol que tuvo el grupo de la élite empresarial en la formación de la hegemonía neoliberal en los años noventa. En primer lugar, se explica en qué consiste este enfoque teórico y, en especial, los conceptos de relaciones de fuerza políticas y de hegemonía. Con estas categorías, es posible comprender las dimensiones ideológica/discursiva y articuladora de la hegemonía neoliberal en sus primeros años. En segundo lugar, se expone brevemente la historia de la élite empresarial en los años previos a la década del noventa, así como el contexto de crisis que permitió el surgimiento de una hegemonía neoliberal. Se aborda, por un lado, el proceso de articulación de la élite empresarial a partir de su unidad gremial, y, por otro lado, se señala cómo la crisis generalizada del anterior paradigma, el desarrollista, fue clave para entender la unidad de las grandes empresas y para comprender el avance de las ideas neoliberales en el campo discursivo. En tercer y último lugar, gracias a contradicciones en la literatura y ciertos vacíos de investigación, se explican, según las categorías gramscianas, los aspectos articulador y discursivo que tuvo la hegemonía neoliberal en sus inicios y el rol dominante de la élite empresarial en su articulación con los demás grupos y en relación con la ideología neoliberal.
Avances conceptuales y metodológicos para la construcción de la Estructura Agroecológica Principal (EAP) de los agroecosistemas
Authors: Cleves Leguízamo José Alejandro
Published: November 2023

Este texto, presenta en forma clara y sistemática los pasos de la planificación agropecuaria, teniendo en cuenta las características propias del sector, contiene conceptos, métodos, técnicas y herramientas de planeación aplicadas a la empresa, así como los pasos que se sugieren para el desarrollo de esta fase en el proceso administrativo.
Estudios en finanzas y gestión en empresas colombianas
Authors: Arabia Jamil , William John , Paola Gina , Johana Sonia , Yasmin Derly , Angel Miguel , Alexander Fredy , Castro Carolina , Yaneth Gladys , del Julia , Medina Inelia , Blanco Fabio
Published: November 2023

Este libro muestra cinco investigaciones que profundizan en temas como la estandarización de la información financiera, el mejoramiento de la gestión y la sostenibilidad financiera, el aseguramiento de los negocios y la cooperación para competir; investigaciones que se desarrollaron a través de varias empresas y sectores estratégicos del país.
Ensueño de imaginación poética en la obra de Julio Flórez
Authors: Avendaño de Barón Gloria Smith
Published: November 2023

Esta publicación deriva de una tesis doctoral de corte filológico, cuyo objetivo principal se centró en la elaboración de una Edición crítica de la obra completa del poeta colombiano Julio Flórez, conformada por ocho obras publicadas en vida, una póstuma, 120 poemas sueltos divulgados en periódicos y revistas nacionales e internacionales, y un poema inédito escrito con puño y letra del poeta. El compilado que aquí se presenta contiene: un estudio previo constituido por entornos histórico-políticos, análisis del ensueño poético de Flórez y criterios de selección y edición de su obra. Se consideró conveniente preparar una selección de la vasta producción poética del autor para darla a conocer a los investigadores en el campo del género lírico y, en general, a las nuevas generaciones de amantes de la poesía
La gestión del recurso humano en la micro y pequeña empresa
Authors: Rodríguez Moreno Diana Cristina
Published: November 2023

En este libro se presentan las razones por las cuales el desarrollo de las micro y pequeñas empresas es imperioso para el progreso económico de un lugar determinado.  espacio en el cual se hace necesario el uso efectivo de los recursos, especialmente el recurso humano, siendo esencial para generar oportunidades empresariales, económicas y sociales.  Lo anterior debido a que cualquier tipo de activo sin la intervención del recurso humano es un recurso pasivo, que no generará el valor deseado y en el cual la intervención de las personas que toman decisiones sobre el patrimonio tangible o intangible además de la aplicación de su trabajo permite la transformación y la generación de valor.
Evaluasi Kurikulum Pendidikan: Memastikan Proses Pembelajaran Sesuai dengan Tujuan Pendidikan
Authors: Ibrahim Ibrahim , Zainuri Ahmad , Yunita Yunita , Kanada Rabial , Hidayat Hidayat
Published: November 2023

Artikel ini membahas tentang evaluasi kurikulum pendidikan di Pondok Pesantren Aulia Cendikia Palembang, dengan latar belakang bahwa evaluasi kurikulum merupakan kegiatan penting dalam pelaksanaan pendidikan pada suatu lembaga pendidikan. Jenis penelitian yakni kualitatif dengan pendekatan deskriptif. Metode yang digunakan dalam pengumpulan data yakni melalui wawancara, observasi, dan dokumentasi. Hasil yang didapat yakni pelaksanaan evaluasi Kurikulum Pendidikan di Pondok Pesantren Aulia Cendikia Palembang sudah dijalankan dengan sesuai dengan prosedur pelaksanaan dari evaluasi terhadap kurikulum pendidikan. Evaluasi kurikulum memegang perenan penting baik dalam penetuan kebijaksanaan pendidikan pada umumnya, maupun pada pengambilan keputusan dalam kurikulum. Hasil-hasil evaluasi kurikulum dapat digunakan oleh para pemegang kebjaksanaan pendidikan dan para pemegang kurikulum dalam memeilih dan menetapkan kebjaksanaan pengembangan system pendidikan dan pengembanagan model kurikulum yang digunakan. Hasil-hasil evaluasi kurikulum juga dapat digunakan oleh guru-guru, kepala sekolah dan para pelaksana pendidikan lainnya, dalam memahami dan membantu perkembangan siswa, memilih bahan pelajaran, memilih metode dan alat-alat bantu pelajaran, cara penilaian serta fasilitas pendidikan lainnya.
Manajemen Pondok Pesantren Dalam Pembentukan Karakter Kemandirian Entrepreneur Santri Pondok Pesantren Salafiyah Baitul Kirom Lampung Selatan
Authors: Syarifudin Amat , Yetri Yetri , Thahir Andi
Published: November 2023

Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis secara mendalam manajemen pondok pesantren dalam pembentukan karakter kemandirian entrepreneur santri Pondok Pesantren Salafiyah Baitul Kirom Lampung Selatan, mulai dari strategi pembentukan, upaya, dan bentuk-bentuk pendidikan entrepreneur. Penelitian ini merupakan penelitian lapangan dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan observasi, dokumentasi dan wawancara. Analisis data menggunakan model interaktif yang terdiri dari pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa: (1) Strategi pembentukan karakter kemandirian entrepreneur santri yaitu pertama, dengan learning by doing (belajar sambil bekerja) atau praktik secara langsung, kedua, adanya manajemen wirausaha oleh pengasuh yang meliputi pelatihan, pendampingan serta evaluasi (2) Upaya dalam pembentukan karakter kemandirian entrepreneur santri dengan membentuk kemampuan insiatif, mengatasi hambatan dan masalah, rasa percaya diri, melakukan usaha tanpa bantuan orang lain dan bertanggung jawab, (3) Program pendidikan karakter kemandirian entrepreneur santri meliputi usaha konveksi baju, loundry, budidaya jamur tiram, perikanan, koperasi (kantin), depot air mineral dan pertanian.
Efektifitas Organisasi Himpaudi Dalam Peningkatan Mutu Pendidikan Anak Usia Dini (PAUD) di Kota Bandar Lampung
Authors: Markuri Popi , Yetri Yetri , Fakhri Jamal
Published: November 2023

Penelitian ini diarahkan untuk mengukur sejauh mana efektivitas organisasi Himpaudi dalam meningkatkan kualitas Pendidikan Anak Usia Dini (PAUD) di Kota Bandar Lampung. Menggunakan metode kualitatif, penelitian ini berfokus pada pendekatan naratif dan studi kasus. Sumber data utama diperoleh melalui wawancara dengan pemimpin Himpaudi, anggota pengurus, serta pejabat PAUD di Kecamatan Bandar Lampung. Teknik pengumpulan data mencakup observasi, wawancara terstruktur, dan pengumpulan dokumen. Proses analisis data meliputi reduksi, penyajian data, dan penyimpulan berdasarkan informasi yang diperoleh. Dari hasil penelitian, ditemukan bahwa Himpaudi menghadapi tantangan dalam meningkatkan kualitas PAUD di Kota Bandar Lampung. Meskipun ada dukungan dari lingkungan eksternal, terdapat kelemahan dalam struktur dan pelaksanaan di dalam organisasi. Tantangan lain termasuk kurangnya koordinasi yang efektif dan variasi dalam partisipasi anggota. Meski kebijakan dan manajemen Himpaudi berfungsi dengan baik, diperlukan lebih banyak evaluasi dan pengawasan internal. Selain itu, ada tantangan dalam strategi pembangunan PAUD oleh Himpaudi, khususnya terkait dengan perluasan, peningkatan kualitas, dan melibatkan masyarakat dan mitra lebih dalam.
Ungleichheit in der Erwerbsteilhabe : Zum Einfluss von betrieblichen Beschäftigungssystemen auf Erwerbsverläufe
Authors: Struck Olaf , Dütsch Matthias
Published: November 2023

Die Verortung auf dem Arbeitsmarkt und die damit verbundenen Erwerbseinkommen und Anwartschaften auf sozialpolitische Transferleistungen bestimmen in starkem Maße die Lebensbedingungen von Individuen. Dabei haben die betriebliche und überbetriebliche Beschäftigungsstabilität für Arbeitnehmer und Arbeitnehmerinnen eine hohe Bedeutung (Giesecke/Heisig 2010; Struck u.a. 2007). Empirisch lassen sich vielfach langfristig stabile Erwerbsverläufe in einem Betrieb beobachten. Teilweise sind status- und einkommensstabile Verläufe oder Aufstiege auch im Falle zwischenbetrieblicher Mobilität vorhanden. Nicht selten weisen Erwerbspersonen jedoch auch diskontinuierliche Erwerbsverläufe auf, die durch häufigere Betriebswechsel, berufliche Abstiege oder Arbeitslosigkeitsphasen gekennzeichnet sind (Struck 2006; Struck/Dütsch 2012). Als ein wichtiger Faktor für chancen- oder risikoreiche Erwerbsverläufe gelten betriebliche Beschäftigungssysteme (vgl. ebd.). Beschäftigungssysteme unterscheiden sich insbesondere hinsichtlich der qualifikatorischen Arbeitsanforderungen und der diesbezüglichen Verfügbarkeit von Personal in Unternehmen oder auf externen Märkten. Der potenzielle Arbeitskräftepool kann von Betrieben zum Teil über attraktive Arbeitsbedingungen, Lohn oder Dauerversprechen beeinflusst werden. Zugleich hängen die Arbeitsnachfrage und das Arbeitsangebot aber auch von weiteren externen Bedingungen ab, etwa von der Wirtschaftsstruktur, von technischen Entwicklungen sowie von der Arbeitsmarkt-, Sozial- und Wirtschaftspolitik. Dazu zählen konjunkturelle Schwünge, der weiter gestiegene Wettbewerbsdruck oder die Flexibilisierungswirkungen der „Hartz“-Gesetze. Vor diesem Hintergrund wird erstens die Frage aufgeworfen, welche Wirkung betriebliche Beschäftigungssysteme auf Erwerbsverläufe haben. Zweitens wird untersucht, ob die strukturellen Veränderungen nach dem Jahr 2000 merkliche Auswirkungen auf die innerbetriebliche Arbeitsorganisation hatten bzw. ob sich die betrieblichen Beschäftigungssysteme in ihrer Größenordnung verändert haben. Damit in Verbindung steht in Anlehnung an die These des „skill-biased technological and organisational change“ (Acemoglu 2002; Bresnahan/Brynjolfsson/Hitt 2002) drittens die Frage nach den daraus resultierenden Folgen: Kommt es zu einer technisch und qualifikatorisch begründeten innerbetrieblichen Segmentierung und führt das zu mehr Ungleichheit an (Erwerbs-)Teilhabe? Diese Arbeit ist im Rahmen des Forschungsprojekts „Erwerbsverläufe und betriebliche Beschäftiungssysteme“ im Verbundprojekt „Dritter Bericht zur sozioökonomischen Entwicklung in Deutschland (soeb 3)“ entstanden, das durch das Bundesministerium für Bildung und Forschung (BMBF) gefördert wird.
Lexical anaphora : a corpus-based typological study of referential choice
Authors: Schiborr Nils Norman
Published: November 2023

Whenever speakers refer to entities or events, they are tasked with making a series of decisions: which entity to refer to, how to embed it into syntactic structures, and which type of expression to use for the reference. This study concerns itself with the last of these decisions, the selection of the linguistic exponents of reference, or referential choice. While it is well known that languages differ greatly in their preference for either pronominal (*she*, *this*) or zero anaphora (ellipsis) to refer back to previously mentioned discourse referents, the overall rates of occurrence of lexically-headed anaphora (*the woman*, *Jane*) in monological discourse turn out to be remarkably stable across languages. This study examines the circumstances in which speakers opt for the more informative but less econominal choice of lexical references over reduced alternatives. It does so from a typological and comparative angle, charting the cross-linguistic stability of certain classes of explanatory factors and the parametricization of others across languages. Rather than adopting a specific theoretical framework in its approach to the question, it instead explores a number of empirical bottom-up approaches, deriving complex analytical categories from multiple levels of relatively basic annotations. Where earlier research on referential choice has been focused predominantly based on written data, or else on small data sets of spoken language from English and other overrepresented languages, this study addresses issues of typological representativity by employing spoken corpora from a diverse set of ten languages, many of which are understudied and endangered.
PENGARUH FAKTOR-FAKTOR SOSIAL TERHADAP IJTIHAD SAHABAT MUâ€™Ä€Z IBN JABAL
Authors: Nofialdi
Published: November 2023

Perdebatan di seputar watak hukum Islam sebagai hukum yang statis dan dinamis masih terus berlanjut. dua kutub pemikiran yang ada masing-masing menganggap hukum Islam bersifat abadi dan tetap. Sementara kelompok lain berpandangan sebaliknya, yakni hukum Islam sangat fleksibel. Tulisan ini akan mengekplorasi ijtihad seorang sahabat bernama Mu'Ã z bin Jabal dan mengeksplorasi metode ijtihad serta menganalisis faktor-faktor sosial yang mempengaruhinya. Tujuannya adalah untuk mendukung pendapat yang mengatakan hukum Islam tidak kaku akan tetapi fleksibel. Dengan mengajukan tiga contoh ijtihad Mu'Äz dalam masalah hukum bagi wanita hamil, pembayaran zakat dengan harga dan warisan orang kafir, terlihat bagaimana pertimbangan-pertimbangan sosial selain teks juga turut mempengaruhi ijtihad Mu'Ã z. Karena tingkat intelektualitasnya yang tinggi, kesalehan dan kedekatannya dengan Nabi Saw, serta kejeliannya dalam melihat suatu persoalan, ijtihad Muaz mempengaruhi secara kuat para Sahabat saat itu, tak terkecuali Umar bin Khattab. dengan demikian, metode ijtihad Mu'Ã z, yang salah satu pertimbangannya adalah berangkat dari persoalan sosial riil dan empiris, adalah metode yang diterima dan diakui sebagai metode yang valid.
DETERMINANTS OF WASTING AMONG UNDER 5 YEARS IN TIMOR LESTE (DHS PROGRAM ANALYSIS 2016)
Authors: Rahmatika Auni , Mahmudiono Trias , Mahmudah Mahmudah , Melaniani Soenarnatalina , Soares Ivo Da Costa
Published: November 2023

One of the countries in Asia that has a high prevalence of wasting is Timor-Leste. The prevalence of wasting in Timor-Leste is 24% in children aged 15-49 months. The purpose of this study is to identify the factors that influence the incidence of wasting in children aged 15-49 months in Timor Leste. This research is an analysis of secondary data from the 2016 Demographic and Health Survey (DHS) in Timor-Leste using a cross-sectional approach. Informants in this study were mothers of toddlers aged 15-49 years and had toddlers aged 15-49 months. the number of samples in this study were 1,207 mothers. Bivariate analysis was performed by Chi-Square test and multivariate test by logistic regression test. The results showed that the factors that influence wasting are low birth weight, history of breastfeeding and mother's education level. Meanwhile, after being analyzed using logistic regression, the most influencing variables were low birth weight babies with a significant value of 0.028 and an OR value of 0.620.
AGE AT MIGRATION, DURATION OF RESIDENCE, AND FERTILITY AMONG FEMALE MIGRANTS INTO JAVA
Authors: Wicaksono Febri , Qonita Nisa
Published: November 2023

Java Island has become main destination for inter-regional migrants in Indonesia for decades. Previous studies has shown that migration can be expected to have a strong effect on fertility behavior of female migrants. The objective of this study is to examine fertility patterns of internal female migrants into Java Island. The generalized poisson regression models are used to investigate the socialization, the disruption, and the adaptation hypotheses in explaining the fertility differences between migrants and non-migrants. This study finds that the fertility rate for migrants is higher relative to the non-migrants. The analysis shows that first, there is a fertility assimilation process in migration into Java Island with fertility increasing gradually with age at migration. Second, there is a fertility disruption process in migration into Java Island with short-term fertility-lowering-effect of migration event. However, this study find no evidence on fertility adaptation process in migration into Java Island.
SPATIAL AUTOCORRELATION ANALYSIS ON CORONAVIRUS TRANSMISSION AND POPULATION DENSITY IN EAST JAVA PROVINCE 2020
Authors: Hutabarat Alda Natasya , Puspitasari Nunik
Published: November 2023

Coronavirus (COVID-19) is a type of disease that has wildly spread during 2020. The transmission of this disease is connected by human activity and hygiene which also means that this disease might related with population density. The goal of this study is to discover the correlation between COVID-19 transmission with population density. The research areas used in this study is East Java Province during 2020. The data used for this study are COVID-19 confirmed cases and population density in 2020 East Java Province from Central Bureau of Statistics. Spatial Autocorrelation and Moran’I Methods used in this study discovered that there are some weak correlations (I=0,247) between COVID-19 cases and population density in East Java Province 2020. There are 9 areas with p value ≤0.05. These areas are Trenggalek Regency, Ngawi Regency, Madiun City with p=0.05 significant. Ponorogo Regency, Madiun Regency, Magetan Regency, Gresik Regency, Sidoarjo Regency and Surabaya City with p=0,001 significant. This discovery has some similarities with other studies.
On the Normal Modes of Coupled Harmonic Oscillators
Authors: Fernández Francisco
Published: November 2023

We discuss in detail a well known method for obtaining the frequencies of the normal modes of coupled harmonic oscillators that is based on the simultaneous diagonalization of two symmetric matrices. We apply it to some simple illustrative examples recently chosen for the presentation of an alternative approach based on a set of constants of the motion. We show that the traditional method is simpler, even in the case of equal frequencies. We also discuss a problem that commonly appears in elementary courses on quantum mechanics that also requires the diagonalization of two symmetric matrices.
Pluvial Flood Susceptibility in the Local Community of the City of Gospić (Croatia)
Authors: Šiljeg Silvija , Milosevic Rina , Mamut Marica
Published: November 2023

Pluvial flooding (PF), triggered by intense short-duration rainfall events, poses a growing challenge in urban areas due to climate change and rapid urbanization. To mitigate the risk, it is imperative to identify flood-prone areas and implement mitigation strategies collaboratively with the public. This study aims to create a GIS-MCDA model of PF susceptibility zones based on topographical, environmental, and hydrological criteria and investigate the public perception of risk in Gospić. The survey included 5% of the city population (N=64), and data were obtained via face-to-face interviews. Five factors were examined: (F1) risk awareness, (F2) anthropogenic and (F3) natural causes of PF, (F4) potential consequences, and (F5) preparedness. All factors have moderate mean values, i.e., awareness, causes of PF, expectations of consequences, and preparedness is moderate. The reliability of questionnaire is very high (> 0.71). The PF susceptibility zones were derived with an accuracy of 76%. The most susceptible zone covers 10% of the city, including agricultural land, forests, meadows, and residential properties. Of all respondents, 36% live in the most flood-prone area. In conclusion, mitigation measures for decision-makers were proposed. Results from this research can be a starting point for further research in Croatia and guidelines for decision-makers in implementing a risk mitigation strategy.
Enterococcal Faecalis Endocarditis in Renal Transplant Patients: Our Experience with Ampicillin and Daptomycin Combination
Authors: Baires Fernando , Arias Erin , Ramos Maria Jose Diaz , Burgos Cesar , Lopez Guillermo , Llompart Juan S , Radwanski Jana , Tillman Tywaun , Valerio Fernando , Sekhon Anupamjeet Kaur , Singh Jarmanjeet , Jinadatha Chetan , Sierra-Hoffman Miguel , Stevens Mark L
Published: November 2023

Globally, the adoption of Solid Organ Transplantation (SOT) as first-line therapy for end-stage organ failure has not come without its share of complications. Enterococcal endocarditis poses a substantial risk to renal transplant patients, and multiple factors must be considered due to the grave nature of this infection. Such factors include addressing multidrug-resistant organisms, antibiotic therapy-related toxicity, and preserving the transplanted organ. Additional considerations include salvaging an affected cardiac valve and avoiding the need for a valve replacement with the attendant complications. Ampicillin and gentamicin have historically been the standard of care as first-line treatment for many years until the aminoglycoside sparing regimen of ampicillin and ceftriaxone showed non-inferiority in clinical studies. We present a second case report with an aminoglycoside sparing regimen of ampicillin and daptomycin in a renal transplant patient who developed Enterococcus faecalis endocarditis. We conclude with a brief review of published research with this combination.
Independent Control of Active and Reactive Power Flow for a Single-Phase, Unidirectional On-Board Power Converter Connecting the DC Power Bus to the AC Bus
Authors: Binkowski Tomasz
Published: November 2023

This article presents a proposed system that enables energy transfer from the dc grid to a single-phase onboard grid, operating at an hi frequency. In addition to the energy transfer function, it additionally enables compensation of reactive power in the ac grid when the converter operates at less than rated power. To operate in compensator mode, it is necessary to decouple the current from the grid into active and reactive components and control them independently. To achieve good dynamics, synchronizers that operate in the dq system are used. In the case of a single-phase grid, it requires such a synchronizer to generate virtual quadrature signals. The used systems based on second-order generalized integrator are good, but to improve dynamics in the work a quadrature generator based on trigonometric calculations was proposed. The developed system was implemented in a proportional resonant current control system. Tests performed in steady state and in dynamic states related to typical grid disturbances showed better dynamic properties than the standard integrator-based system.Keywords: power transfer; compensator; P+R controller
Awareness-based Choice Selection: Improving the Decision-making Efficiency by Using Known Information
Authors: Farhadi Ashkan
Published: November 2023

Background: Consciousness is usually interpreted as a state of being aware of one’s environment as well as self. According to the trilogy paradigm of consciousness (or simply “trilogy”), it is primarily guided by two new mental functions—awareness-based choice selection (ABCS) and discretionary selection of information for awareness (DSIA) or intentional attention—which may play a role in the choice selection during decision making. Method: To test whether ABCS and DSIA could improve the choice selection efficiency, 204 subjects were recruited using social media platforms to complete an anonymous online survey. The survey was designed to examine the role of subtle hints and cues in guiding participants’ attention toward a particular subject of awareness and this in return would increase the likelihood of selecting a correct choice among the proposed options, thereby enhancing the decision-making efficacy. Results: The participants’ attention could be successfully swayed to a particular subject matter (DSIA) in 59−73% of occasions. In addition, using ABCS increased the efficiency of selecting a correct choice among presented options. The analyses further revealed a gap between the selecting a choice during decision-making process and its execution, which is indicative of an appropriation process. Conclusion: The present study shows that sheer knowledge of facts may not be sufficient for selecting a correct choice among presented options effectively. However, as ABCS improves the choice selection efficiency, it plays an instrumental role in determining the subject of awareness, indirectly supporting the notion of DSIA.
Observations, Remote Sensing and Model Simulation to Ana-lyze Southern Brazil Antarctic Ozone Hole Influence
Authors: Peres Lucas Vaz , Pinheiro Damaris Kirsch , Bencherif Hassan , Bègue Nelson , Bageston José Valentin , Bittencourt Gabriela Dornelles , Portafaix Thierry , Schuch André Passaglia , Anabor Vagner , Da Silva Rodrigo , Neves Theomar Trindade , Silva Raphael Tapajós , Dos Reis Gabriela Godinho , Dos Reis Marco Godinho , Martins Maria Paulete , Toihir Mohamed A. , Mbatha Nkanyiso , Steffenel Luiz Angelo , Mendes David
Published: November 2023

The paper presents the observational, remote sensing and model simulation to analyze Southern Brazil Antarctic Ozone Hole influence (SBAOHI) events occurred between 2005 and 2014. To an-alyze it we use Total Ozone Column (TOC) data provide by Brewer Spectrophotometer (BS) and OMI (Ozone Monitoring Instrument) instrument satellite, besides the AURA/MLS (Microwave Limb Sounder) instrument satellite ozone profiles was utilized with DYBAL (Dynamical Barrier Localization) code in MIMOSA (Modélisation Isentrope du transport Mésoéchelle de l’Ozone Stratosphérique par Advection) model Potential Vorticity (PV) fields. TOC has 7.0 ± 2.9 DU re-ductions average in 62 events. October have more events (30.7%). Polar Tongue events are 19.3% of total, being in October more frequently observed (50% of cases), with medium intensity (58.2%) and in stratosphere medium levels (55.0%). Already Polar Filament events (80.7%) are more frequent in September (32.0%), medium intensity (42.0%) and in stratosphere medium lev-els (40.7%). ENSO index positive phase influenced 61.3% of events, having dominance in all in-tensity categories (minor 57.9%, medium 51.6%, major 58.3%), while the equilibrium dominate the QBO influence with 50% of total cases in positive phase and 50 % in negative phase.
A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
Authors: Afshari Nousha , Koturbash Igor , Boerma Marjan , Newhauser Wayne , Williams Jacqueline , Kratz Maria , Willey Jeffrey , Chancellor Jeffery
Published: November 2023

Astronauts in space are subject to a continuous bombardment of ionizing radiation. The Earth's magnetic field and the ISS shield some biologically damaging particles traveling through. Still, travel beyond low-Earth orbit and extravehicular activities are exceedingly more dangerous and there is a concern for the acute and late-occurring adverse health effects befalling astronauts. So, it is vital to consider the current tools and models used to describe and study the organic consequences of ionizing radiation exposure. It is equally important to see where these models may improve. This article reviews the historical development and current state of knowledge of radiation effects impacting astronauts in orbit. We explain the space radiation environment, cellular microenvironment, and how these may be incorporated in radiobiological models to aid in our understanding of the influence space travel may have on astronaut health. The topics discussed in this paper include a review of DNA damage and repair mechanisms and the numerical models that aim to explain the biological effects resulting from ionizing radiation damage. Historically, radiobiological models focused on how radiation damages nuclear DNA, built upon the hypotheses of Crowther and Lea in the 1940s and 1960s, and neglected other sub-cellular targets outside of nuclear DNA.
Evaluation of the Therapeutic Effect of Fly Maggot Antimicrobial Peptide in Staphylococcus aureus-Induced Mouse Mastitis Model
Authors: Wang Zhengli , Yan Jiaxu , Liu Tingting , Zhu Jianjun , Ma Yan , Li Ning , Fan Wenhua , Wang Jungang , Shen Hong
Published: November 2023

Staphylococcus aureus(S. aureus) is associated with mastitis in dairy cows, this study investigates the therapeutic effect of maggot antimicrobial peptides on S. aureus induced mastitis in mice. The maggot AMP was isolated and purified, tested for antimicrobial activity, and used to treat a pathological model of rat mastitis. The concentration of 1.5mg/（Kg. BW）AMP was selected as intramammary treatment in S. aureus-induced mastitis in mice. The mice were divided into four groups of 30 mice each: group I (healthy control), group II (disease control), group III (AMP), and group IV (ciprofloxacin). To evaluate the therapeutic efficacy of maggot AMP in mastitis induced by S. aureus based on clinical presentation, mammary gland structure, bacterial load, histopathology, and cure. During the 7-day treatment period, all the mice in Group II died in the afternoon of the fifth day, and the clinical signs of the mice in Group III began to improve on the third day, as evidenced by the gradual recovery of the mice's mental status, dietary intake, and water intake. During the treatment period, the bacterial load count of Group III was significantly lower than that of Group II but higher than that of Group IV, while the bacterial load count of Group III gradually decreased and approached that of Group IV from the fifth to the seventh day. The levels of TNF-α in groups III and IV were significantly lower than those in group II, suggesting that maggot AMP has a certain inhibitory effect on TNF-α. Treatment with AMP@ 1.5 mg/(Kg. BW) showed restoration of clinical signs, reduced bacterial load, and lower TNF-α levels in mice, leading to significant improvement in histopathological changes as compared to disease controls. The final cure rate was 40% for mice in Group III compared to 70% for mice in Group IV, compared to all mice in Group II that died. From this study, it can be concluded that maggot AMP can be used as a potential alternative treatment option to antibiotics for the treatment of bovine mastitis.
Assessing Derawan Island's Coral Reefs Over Two Decades: A Machine Learning Classification Perspective
Authors: Ummam Muhammad AL Fadio , Manessa Masita Dwi Mandini , Efriana Anisya Feby , Semedi Jarot Mulyo
Published: November 2023

This study provides a comprehensive assessment of Derawan Island's coral reefs over two decades (2003, 2011, and 2021) from a machine learning classification perspective. Employing non-parametric algorithms like Random Forest (RF), Support Vector Machine (SVM), and Classification and Regression Tree (CART), our analysis primarily focused on spatial and temporal changes in coral habitats. RF emerged as the most accurate method, demonstrating an accuracy of 71.43% with Landsat 9, 73.68% with Sentinel 2, and 78.28% with Multispectral Aerial Photos. We found that the accuracy of our classification results was significantly influenced by the geographic resolution, as well as the quality of field and satellite/aerial image data. Through spatial clustering, the coral habitats exhibited an Nearest Neighbor Index (NNI) value of 0.8727, indicating specific patterns of distribution. The analysis revealed a decrease in coral reef extent from 2003 to 2011, shrinking to 16 hectares with varying densities, followed by a slight area increase but with more heterogeneous densities between 2011 and 2021. This study not only highlights the dynamic nature of coral reef habitats over two decades but also underscores the critical role of machine learning in environmental monitoring and conservation efforts.
Printed Composite Film with Porous/ Micropyramide Hybrid Conductive Architecture for Multifunctional Flexible Force Sensor
Authors: Wang Yi-Fei , Yoshida Junya , Takeda Yasunori , Yoshida Ayako , Kaneko Takeru , Sekine Tomohito , Kumaki Daisuke , Tokito Shizuo
Published: November 2023

Porous structures and micropatterning surfaces play a crucial role in the development of highly sensitive force sensors. However, achieving these two conductive architectures typically requires complex materials synthesis and expensive manufacturing processes. In this study, we introduce a novel conductive composite film featuring a porous/micropyramid hybrid conductive architecture, which is achieved through a straightforward process of materials mixing and one-step screen printing. By utilizing a deep eutectic solvent in the ink component, micropores are induced in the printed composite, while the mesh of the screen mask acts as a template, resulting in a micropyramid film surface. We have successfully realized highly sensitive flexible force sensors with multifunctional capabilities for perceiving normal force and shear force.
An Artificial Intelligence-Based Framework for Supporting Management of Patients Affected by Dementia
Authors: Guzzi Pietro Hiram , Veltri Pierangelo
Published: November 2023

Dementia is a major issue for healthcare systems worldwide, necessitating the development of creative and effective strategies for its management. This paper examines the use of Artificial Intelligence (AI) technologies in caring for and managing people with dementia. AI-driven solutions can improve diagnosis, personalize care, optimize medication management, and reduce the burden on caregivers. This paper discusses the implementation of an AI-based framework for creating videos related to people’s memories to support train-therapy or travel- therapy, a non-pharmacological intervention for Alzheimer’s disease patients
Toxicity of AMPA to the Freshwater Planarian (Girardia tigrina)
Authors: Pochron Sharon T. , Sasoun Samy , Maharjan Siddhartha , Pirzada Wali U. , Byrne Samantha Hallie , Girgis Mary , Jacobellis Morgan A. , Mitra Johanna , Miranda Alec S , Gelder Grace Van , Khan Sayeed
Published: November 2023

The widespread use of the herbicide glyphosate has resulted in the global presence of its degra-dation product, aminomethylphosphonic acid (AMPA), in the global environment. AMPA is commonly found in water bodies, including freshwater systems. We investigated the effects of chronic and acute AMPA exposure on the survivorship, regenerative abilities, and locomotion of the brown planarian (Girardia tigrina), a water-dwelling flatworm commonly found in freshwa-ter ecosystems. We exposed planarians to two concentrations of AMPA, consistent with the high and low ranges of concentrations observed in US water systems. We measured endpoints includ-ing survivorship, regenerative abilities of head and tail segments, eyespot regeneration, and swimming speed. Compared to the control group, we found that planarians chronically exposed to AMPA exhibited (1) modestly reduced survivorship while regenerating and (2) slower regen-eration from the tail segment. No significant differences were observed in intact body growth during chronic exposure. Our findings highlight the potential ecological impacts of AMPA con-tamination on planarian populations. Understanding the effects of AMPA exposure on planarians contributes to our understanding of the ecological consequences of glyphosate use in freshwater ecosystems.
Anti-cancer and Anti-angiogenic Effects of Curcumin and Epigallocathechin-3-Gallate in a Mouse Model of Renal Cancer
Authors: Barbieri Antonio , Aliberti Silvana Mirella , Barretta Maria Luisa , Picone Carmine , Luciano Antonio , Barbieri Massimiliano , Scognamillo Giosuè , Santonastaso Clemente , Alfieri Tiziana , Sarnicola Fatima , Petrillo Antonella , Cianciola Emidio , Funk Richard H. W. , Capunzo Mario , Giudice Aldo
Published: November 2023

Although conventional chemotherapeutic drugs are the first line of treatment for cancer, they have numerous side effects. One of the emerging challenges in cancer treatment is drug resistance. Nat-ural compounds have proven effective against various hallmarks of cancer for their multi-target inhibition properties, but especially for their ability to synergistically bypass low bioavailability. Methods: The present study investigated the in vivo antitumor effects of a combination of two natural dietary agents, epigallocatechin-3-gallate (EGCG) from Camelia Sinensis and curcumin, a component of turmeric (Curcuma longa). We aimed to compare, for the first time in vivo, the antiangiogenic and antitumor effects of sunitinib with the combination of curcumin and EGCG in a mouse model of renal cell carcinoma (ccRCC). It was shown that they are able to inhibit cell survival, proliferation of several type of cancer, including renal cell carcinoma (ccRCC), by mod-ulating different signaling pathways and that their combination respect to single compound syn-ergistically decreased angiogenesis. Results: Herein, we highlighted that these compounds inhib-ited the growth of xenografted renal cancer in nude mice by significant inhibition of tumor vol-ume, tumor weight and CD31 expression with no signs of hepatic toxicity. Moreover, mice treated with these natural compounds showed a significant reduction in angiogenesis and an improve-ment in survival rate with p<0.05. Finally, pretreatment of mice with a diet containing 0.6% curcumin before injection of tumor cells showed a significant inhibition of tumor engraftment in 60% of mice with respect to controls and other groups. Conclusions: Taken together, our data in-dicate, for the first time, that the combination of curcumin and EGCG acts in a synergistic manner to inhibit the growth and angiogenesis of ccRCC and with less toxicity than sunitinib and provide an important rationale for future clinical development for chemoprevention and treatment of re-nal cancer.
Lessons from the Varietal Evolution of Durum Wheat in Italy
Authors: Careddu Martina Ludovica , Giunta Francesco , Motzo Rosella
Published: November 2023

The leading role of Italy in the cultivation of durum wheat stimulated intense breeding activities in the country from the beginning of the 20th century, much earlier than any other country involved in durum wheat production. Older, genetically more heterogeneous landraces became replaced with new highly productive, superior quality varieties, and this led an inevitable reduction in overall genetic diversity among new cultivars, which makes the genetic variability of the old cultivars preserved particularly valuable and important. The aim of this paper was to assist future breeding programmes by providing a detailed description of the history of durum wheat breeding in Italy and of the changes in yield, quality and related traits that subsequently occurred, starting from the most diffuse landraces present between 1900 and 1920 up until the present day. The parallel evolution of breeding techniques, breeding goals and agricultural systems in this period is also described, and some future breeding goals suggested. In the current context of climate change and of rapidly mutating pathogen populations, preserving the yield level with the continuous introduction of new cultivars by exploiting the reservoir of largely unused genetic variation stored in old cultivars and landraces could be as important as increasing grain yield and quality.
Persisting Shadows: Unraveling the Impact of Long COVID-19 on Cardiovascular, Nervous, and Respiratory Systems
Authors: Sideratou Christina-Michailia , Papaneophytou Christos
Published: November 2023

The coronavirus disease 2019 (COVID-19), instigated by the zoonotic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), rapidly transformed from an outbreak in Wuhan, China, into a widespread global pandemic. A significant post-infection condition, known as ‘long- COVID’, emerges in a substantial subset of patients, manifesting with a constellation of over 200 reported symptoms that span multiple organ systems. This condition, also known as 'post-acute sequelae of SARS-CoV-2 infection' (PASC), presents a perplexing clinical picture with far-reaching implications, often persisting long after the acute phase. While initial research focused on the immediate pulmonary impact of the virus, the recognition of COVID-19 as a multiorgan disruptor has unveiled a gamut of protracted and severe health issues. This review provides a summary of the primary effects of long COVID on the cardiovascular, nervous, and respiratory systems. It also delves into the mechanisms underlying these impacts and underscores the critical need for a comprehensive understanding of long COVID's pathogenesis.
Questionnaire of Physiotherapeutic Specific Exercises of Scoliosis – QPSSE
Authors: Grivas Theodoros B. , Dadakaridou Dimitra , Fokidi Stavroula A. , Kastrinis Alexandros , Kosti Melpomeni , Michas Constantinos , Oikonomaki Marianna , Theodosopoulos Evangelos , Griva Artemis Margarita
Published: November 2023

Study design: Creating and psychometric testing of a new QoL Questionnaire about Physiotherapeutic Specific Exercises of Scoliosis (Questionnaire of Physiotherapeutic Specific Exercises of Scoliosis -QPSSE).
Purpose: The purpose of this study is to create a reliable and valid questionnaire for patients suffering mild and moderate adolescent idiopathic scoliosis (AIS) who have been treated with Physiotherapeutic Specific Exercises of Scoliosis (PSSE) in order to evaluate their quality of life.
Materials and Methods: The developed questionnaire was based on a thorough literature review as well as on authors experience. It consists of 53 questions, of which 37 have a positive meaning, 15 have a negative meaning, and one is multiple choice question, additionally there are six “open” questions. Except for the multiple choice question, all other questions are answered on a Likert scale ranging from 1 to 5 scores. 5 represents a positive meaning or very much, whereas 1 stands for a negative meaning or not at all. Questions were developed by the authors who subsequently categorized the 53 questions into the following 8 domains: physical functioning, self-image, Physiotherapeutic Scoliosis-Specific Exercises (PSSEs), psychosocial functioning, cognitive functioning, compliance, motivation and pain. A pilot study was conducted so that we could calculate Cronbach’s Alpha based on the outcome. Due to the COVID-19 pandemic, the authors worked through the Zoom online platform to structure the questionnaire.
Results: Pearson's correlation coefficient was used for all correlations evaluated. P values of less than 0.05 were considered to be significant. Internal consistency was evaluated with Cronbach's alpha. Although there were very few missing values, accounting for 0.78% of the total values of the questionnaire, expectation maximization likelihood algorithm was used to impute data. IBM® SPSS® Statistics Software v.25 was used for the analysis. Cronbach's alpha coefficients for the overall score was 0.84.
Conclusion: This original QPSSE was found to be a reliable and valid tool for AIS treated conservatively with PSSE and for their clinicians.
Processes Controlling the Actin-Myosin Contractile Ring During Cytokinesis in Fission Yeast
Authors: Rezig Imane , Yaduma Wandiahyel , McInerny Christopher
Published: November 2023

Cytokinesis, as the last stage of the cell division cycle, is a tightly controlled process amongst all eukaryotes, and defective division can lead to severe cellular consequences, and is implicated in serious human diseases and conditions such as cancer. Both mammalian cells and the fission yeast Schizosaccharomyces pombe use binary fission to divide into two equal sized daughter cells. In S. pombe such cytokinetic division is driven by the assembly of an actin-myosin contractile ring (ACR) at the cell equator between the two cell tips. The ACR is composed of a complex network of membrane scaffold proteins, actin filaments, myosin motors, and other cytokinesis regulators. Contraction of the ACR leads to the formation of a cleavage furrow which is severed leading to the final cell separation during the last stage of cytokinesis, abscission. This review describes recent findings defining the three phases to establish cytokinesis in S. pombe: ACR assembly, ACR constriction, and its coordination with septation. Collectively, we provide an overview of current understanding of the mechanisms regulating the ACR-mediated cytokinesis in S. pombe.