bluuebunny/crossref_metadata_2025 huggingface dataset:
FIGURE 2 from Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation
Authors: O'Brien Valerie P. , Kang Yuqi , Shenoy Meera K. , Finak Greg , Young William C. , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E. , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M. , Koch Meghan A. , Gottardo Raphael , Salama Nina R.
Published: September 2023

Hp+KRAS+ mice have abundant metaplastic pit cells that express the intestinal mucin Muc4. A, The normalized expression of the indicated metaplasia and dysplasia genes is given for the cells from UMAP #2 (Fig. 1C). Asterisks indicate metaplastic pit cells. B, The estimated proportion of cells from the scRNA-seq experiment that were assigned to the indicated pit cell clusters is shown. Each datapoint shows the total number of estimated cells of that subcluster for the given treatment group, reported as the percentage of all cells from that treatment group in UMAP #2. Error bars represent the confidence interval that a given percentage of cells would be identified as the given cluster type based on their observed distribution. C, The contour plots show Muc5Ac (x-axis) and Muc4 (y-axis) expression in the indicated pit cell clusters from UMAP #2. Expression is given as arbitrary units and negative values are due to data scaling for visualization purposes. D, Gene set enrichment analysis was performed to assess biological pathways and processes enriched in pit_2, pit_6, and pit_8 cells relative to the five other pit cell clusters, using Hallmark, KEGG, and GO pathway datasets from the MSigDB database. E and F, ISH was used to detect the intestinal mucin Muc4 (brown) in gastric corpus tissue (counterstained with hematoxylin, blue) from the indicated treatment groups at 12 weeks. E, Representative images are shown. Scale bars, 100 μm. Arrows show Muc4 expression at the epithelial surface in KRAS− samples. F, Tissues were scored in a blinded fashion. N = 5 independent experiments were performed with n = 3–8 mice per group. Data represent actual values from each individual mouse and bars indicate the median values.
Data from PARP Inhibitors Effectively Reduce MAPK Inhibitor Resistant Melanoma Cell Growth and Synergize with MAPK Inhibitors through a Synthetic Lethal Interaction In Vitro and In Vivo
Authors: Fröhlich Lisa Marie , Niessner Heike , Sauer Birgit , Kämereit Sofie , Chatziioannou Eftychia , Riel Simon , Sinnberg Tobias , Schittek Birgit
Published: September 2023

The efficacy of targeting the MAPK signaling pathway in patients with melanoma is limited by the rapid development of resistance mechanisms that result in disease relapse. In this article, we focus on targeting the DNA repair pathway as an antimelanoma therapy, especially in MAPK inhibitor resistant melanoma cells using PARP inhibitors. We found that MAPK inhibitor resistant melanoma cells are particularly sensitive to PARP inhibitor treatment due to a lower basal expression of the DNA damage sensor ataxia-telangiectasia mutated (ATM). As a consequence, MAPK inhibitor resistant melanoma cells have decreased homologous recombination repair activity leading to a reduced repair of double-strand breaks caused by the PARP inhibitors. We validated the clinical relevance of our findings by ATM expression analysis in biopsies from patients with melanoma before and after development of resistance to MAPK inhibitors. Furthermore, we show that inhibition of the MAPK pathway induces a homologous recombination repair deficient phenotype in melanoma cells irrespective of their MAPK inhibitor sensitivity status. MAPK inhibition results in a synthetic lethal interaction of a combinatorial treatment with PARP inhibitors, which significantly reduces melanoma cell growth in vitro and in vivo. In conclusion, this study shows that PARP inhibitor treatment is a valuable therapy option for patients with melanoma, either as a single treatment or as a combination with MAPK inhibitors depending on ATM expression.
Significance:
We show that MAPK inhibitor resistant melanoma cells exhibit low ATM expression increasing their sensitivity toward PARP inhibitors and that a combination of MAPK/PARP inhibitors act synthetically lethal in melanoma cells. Our study shows that PARP inhibitor treatment is a valuable therapy option for patients with melanoma, either as a single treatment or as a combination with MAPK inhibitors depending on ATM expression, which could serve as a novel biomarker for treatment response.
A Critical Discourse Analysis of Former Davao City Mayor Sara Duterte’s State of the City Addresses (SOCAs)
Authors: Aperocho Maico Demi B. , Flores Seth A. , Gabisan Jenyvive G. , Ygay Noevy Jane B.
Published: September 2023

This study examined the discourses in the State of the City Addresses (SOCAs) of the former Mayor Davao City Sara Duterte-Carpio. Specifically, the rhetorical expressions, semantic expressions, linguistic features, and classifications of ideologies in the political discourses were explored. Through a Critical Discourse Analysis, the researchers explored the use of language and the ideologies represented in such. Findings show that the SOCAs of former Davao City Mayor Sara Duterte-Carpio contained a variety of rhetorical expressions and discourse patterns. The researchers also found significant results about semantic macrostructures, which vary from one speech to another. The ideology of positive Us was also represented through powerful statements that show the importance of former Mayor Sara's leadership, administration, projects, and all people involved in her success. The researchers conclude that the former Davao City Mayor used words powerfully to highlight essential accomplishments and to express the value of the critical actors that made these achievements possible.
Electronic Strategic Intervention Material (e-SIM) in Grade 7 (Biology): Effects on Students’ Performance
Authors: Buitre Shirlyn Lorenzana
Published: September 2023

As everyone is conforming to living with the pandemic, all offers and possible means in the education sector must be applied to help every learner manage their assignments. To help educators in assisting learners in doing their home works, DepEd Memo No. 177 s. 2005 -Training Workshop on Strategic Interventions for successful learning was created.  This intervention aimed to enhance teachers’ skills in test analysis and interpretation and capacitate them in developing varied intervention materials for remediation and enrichment of knowledge. This training prompted the teachers to develop and use Strategic Intervention Material in teaching their subject areas. This study attempted to determine the effectiveness of electronic strategic intervention material in conducting remedial lessons in Grade 7 Biology in a public national high school, Division of Antipolo City for the school year 2022-2023. This study utilized Quasi-experimental research with Non-print Rating Sheets and pretest and posttest as data gathering instruments. Pretest and posttest were administered to thirty-five (35) Grade 7 students to measure their academic performance before and after the use of the Electronic Strategic Intervention Material. The findings showed that Science experts and teachers evaluated the e-SIM with grand mean ratings of 3.88 and 3.87, respectively, verbally interpreted as Very Satisfactory in terms of content quality, instructional quality, technical quality, and accuracy and up-to-datedness. Results also showed that there is a significant difference between the academic performance of the student respondents on the pretest and posttest after the utilization of e-SIM as revealed by the computed mean scores of 13.37 for the pretest and 34.77 for the posttest.
Pollutant Burden on Pollution Sources in the Wai Batu Merah Watershed, Sirimau District, Ambon City
Authors: Matulessy Riddo Charles , Kunu Pieter J. , Kaya Elizabeth
Published: September 2023

This study aims to identify sources of pollution and determine the magnitude of the potential pollution load from pollutant sources in the Wai Batu Merah watershed, Sirimau District, Ambon City. The method for identifying sources of pollution is carried out by using saturated or census sampling methods, calculating pollutant loads using direct methods for point source pollutant sources and indirect methods for non-point sources . The direct calculation method uses wastewater discharge data and the results of wastewater quality analysis results from measurements directly at the point source pollutant wastewater treatment plant (WWTP). The wastewater sampling technique uses the grab sampling method. While the indirect method uses effluent factors and supporting data from non-point source pollution sources that have been identified in the Wai Batu Merah watershed. The results showed that the pollutant sources found in the Wai Batu Merah watershed were point sources originating from hotel and health facility activities and non-point sources originating from domestic activities from residential areas, agricultural and livestock businesses, non-point source land (forest and open land), micro, small and medium enterprises (MSMEs), small scale industries and waste. The dominant pollutant source in the Wai Batu Merah watershed comes from domestic non-point sources. The highest point source pollution loads for BOD, COD and TSS parameters in the Wai Batu Merah watershed came from hotel activities in segment 6 with the contribution of each parameter of 17.82 kg/day, 23.82 kg/day and 0.029 kg/day. Meanwhile, the highest non-point source pollution load for BOD, COD and TSS parameters came from non-point source waste in segment 6 with the contribution of each parameter of 2825.3 kg/day, 3884.8 kg/day and 2684.03 kg/day.
Storytelling in the Classroom: Why it Matters in Event Marketing Education
Authors: Vergara Raymond Allan G. , Vergara Kimberly Christie S.
Published: September 2023

This study examines why students value storytelling in the classroom and explores how they learn event marketing through this pedagogical tool. Using a post course assessment survey, this qualitative study finds that students value storytelling because stories make it easier for them to understand and digest the subject matter in fun and relatable way. Listening to stories allow them to take on a different and new perspective, allowing them to make sense of new information and master concepts. Storytelling can be entertaining and immersive, which helps develop in students positive learning-related attitudes, values, and beliefs.
Unlocking Growth Opportunities for Philippine Micro, Small, and Medium Enterprises through Facebook Advertising and Growth Hacking Strategies in the Post-Pandemic Era
Authors: Guillen Nelson , Lim Cristina Teresa
Published: September 2023

The rapid digitalization and changing business landscape in the post-pandemic era have presented new growth opportunities and challenges for micro, small, and medium enterprises (MSMEs) in the Philippines. This study aims to explore the potential of Facebook advertising and Growth Hacking strategies as effective tools for unlocking growth opportunities for Philippine MSMEs during this transformative period. This study adopted survey research with 100 MSME owners and managers in Metro Manila, which investigated the current usage, perceptions, and effectiveness of Facebook advertising and growth hacking strategies. Additionally, it examined the factors influencing the adoption and implementation of these strategies, such as resource availability and digital literacy. The study’s findings intend to contribute to the understanding of how MSMEs in the Philippines can leverage Facebook Advertising and Growth Hacking strategies to drive business growth and navigate the evolving market dynamics in the post-pandemic era. The insights gained suggest practical implications for MSMEs, marketers, and policymakers, informing the development of tailored strategies and support mechanisms to utilize these digital tools for sustainable growth effectively.
Students’ Mastery of English Grammar towards Effective Writing and Speaking Competence
Authors: Sacal Patrick Glenn Y. , Potane Joel D.
Published: September 2023

English language proficiency is one of the most pressing issues, particularly in the field of education. Speaking and writing are two of the most important macroskills to master, especially in today's increasingly connected world.  The current study seeks to ascertain students' comprehension and mastery of English grammar and explores whether grammar explains the students' proficiency in speaking and writing in Grade 10 Junior High School. The respondents were chosen for the study using a simple random sampling design. Additionally, the researcher's questionnaire, with three qualified validators tested for validity and a pilot tested for reliability, produced a satisfactory Cronbach's alpha result and served as the basis for gathering the study's data. Findings show that students' competence in English grammar, writing, and speaking is satisfactory. The outcome demonstrates that mastery of English grammar accounts for developing an acceptable level of speaking and writing abilities. The study concluded that students' command of English grammar explains their writing and speaking abilities.
Sobre a abundância de coisas, palavras e músicas
Authors: Barros Cassiano de Almeida
Published: September 2023

Em 1606, o músico alemão Joachim Burmeister publicou em Rostock sua poética musical com o objetivo de sistematizar o processo criativo musical, constituir material didático para a escola latina onde atuava, difundir esse conhecimento e preservar as práticas musicais vigentes. Esse tratado é reconhecido pela originalidade da sistematização que propõe e que iniciou uma tradição especificamente luterana de escrita, leitura e interpretação musical, baseada na estreita relação entre poesia e música. Para a formulação dessa sistematização, Burmeister tomou como ponto de partida a ideia de que o espaço da elaboração musical seria aquele da compositio elocutiva das palavras e que essa mesma elaboração devia ser proporcional ao estilo das palavras, de maneira que a música resultante contribuísse para torná-las mais persuasivas. Nesses termos, podemos compreender que os diferentes estilos musicais se caracterizariam, em parte, por diferentes estilos poéticos e, em parte, pelas formas particulares de elaboração musical deles, codificadas retoricamente pela tratadística existente. Em seu Musica Poetica, Burmeister categorizou uma série de artifícios e técnicas musicais baseando-se nas referências mais próximas e comuns de seu tempo, dentre as quais destaco o De utraque verborum ac rerum copia (1512) de Erasmo de Roterdã. Assim como Erasmo reformulou e atualizou em seu tratado os preceitos relativos à abundância de pensamentos e palavras, Burmeister reformulou e atualizou, para o contexto luterano, os preceitos relativos à abundância de artifícios musicais. Neste artigo, proponho analisar as relações entre o tratado de Burmeister e o de Erasmo, investigar o caminho das ideias que os unem, suas aproximações e distanciamentos, e conhecer os fundamentos daquilo que se convencionou chamar desde o século XVII de retórica musical.
Canto coletivo e canto coral: um estudo sobre a música vocal moçambicana
Authors: Muhera Mauro Albino , Silva Vladimir Alexandro Pereira
Published: September 2023

O objetivo do presente artigo é caracterizar as práticas do canto coletivo e do canto coral em Moçambique. Baseado em vários estudos, tratamos da makwayela, das Canções Revolucionárias e do movimento coral em Maputo, abrangendo grupos específicos, como o Majescoral, e eventos, como o Fest Coros. Abordamos, também, os princípios que norteiam a criação e execução dos repertórios cantados polifonicamente, incluindo aqueles ligados à harmonia e à condução vocal. Os resultados apontam que o ato de cantar em conjunto, em Moçambique, antecede a era colonial e a implantação das igrejas cristãs e que o canto coletivo tem os seus elementos típicos, que se desenvolvem dentro de um contexto social. Além disso, observamos que programas como o Fest Coros e o trabalho de várias instituições públicas e privadas ajudam na massificação do canto coral no país. Por fim, concluímos que esse tipo de investigação amplia a visibilidade da prática coral moçambicana em outros contextos, expandindo as possibilidades de atuação de coros, regentes e preparadores vocais.
Sons cotidianos fixados em suporte: espaço, memória e narrativa
Authors: Scarpa Neto Orlando
Published: September 2023

Este artigo discute espaço, memória e narrativa na percepção de sons cotidianos gravados. Com base nas ideias acerca de cotidiano de Agnes Heller e Michel De Certeau, propõe-se um conceito de som cotidiano. A partir desta conceituação, é visto como espaço, memória e narrativa articulam a nossa percepção de sons cotidianos gravados. Sons cotidianos, quando fixados em um suporte, criam uma ideia de espaço e estimulam a memória ao remeter às experiências cotidianas do próprio ouvinte. A relação entre espaço e memória dá origem ao conceito de narrativa aqui proposto, onde narrativa é o contexto geral criado na imaginação do ouvinte durante a experiência de escuta de sons cotidianos gravados. Este jogo entre espaço, memória e narrativa é central na percepção de sons cotidianos fixados em um suporte e é uma distinção importante entre a experiência de escuta destes e a de sons instrumentais gravados. Adicionalmente, este artigo apresenta algumas reflexões acerca do trabalho de criação sonora com sons cotidianos.
Música e instituições culturais: contribuições para uma musicologia urbana na Blumenau do século XX
Authors: Pereira Tiago
Published: September 2023

Com base nos estudos da chamada musicologia urbana, por meio desse artigo busca-se historicizar as relações de produção, consumo e recepção de música, bem como a circulação de músicos e seus repertórios no contexto das principais instituições culturais seculares do núcleo urbano de Blumenau, Santa Catarina, na primeira metade do século XX. Toma-se o Teatro Frohsinn, localizado na Rua das Palmeiras, primeiro centro da cidade (Stadtplatz), local onde se reuniam inúmeras sociedades de canto e música (bandas), que executavam um repertório majoritariamente em alemão. Com o desenvolvimento do núcleo urbano, a área central de Blumenau ficou caracterizada pela Rua XV de Novembro, que se tornou a rua principal e comercial da cidade, espaço no qual se instaurou a nova sede para o Frohsinn, que se tornou Sociedade Dramático-Musical Carlos Gomes, adaptando-se às realidades sociopolíticas da época, como a Campanha de Nacionalização, difundindo sobretudo a música de concerto. A música popular urbana teve maior trânsito fora dos teatros, como nos salões de baile onde as bandas da cidade costumavam performar e no cinema de rua, o Cine Busch, também localizado na região central da cidade que, possuindo palco, era local de apresentações de grupos de outras regiões.
Pertencimento e performance: diálogos entre a música escrita e a improvisação no canto coral
Authors: Castiglioni Paula
Published: September 2023

O canto coral é uma manifestação social cuja ação principal é o canto coletivo, o qual contextualiza tais relações, influenciando os processos de convivência humana entre os envolvidos. Este artigo aponta como fazeres vocais coletivos, que considerem as dimensões da colaboração e cultivo da sensação de pertencimento no momento da performance, podem ampliar a conexão humana entre integrantes do coro, proporcionar ambientes acolhedores e consequentemente aprofundar detalhadamente resultados concernentes à sonoridade coletiva do grupo. Propõe-se refletir sobre duas perguntas: - Como os cuidados e práticas regulares em relação à dimensão da coletividade e interação social influenciam na qualidade da performance musical de um grupo coral? - Podem os processos de improvisação vocal colaborar para a criação de vínculos coletivos e consequentemente levar a resultados mais profundos na performance em todos os níveis em que ela pode se dar? Como referências teóricas principais, o trabalho se baseia em Émile Durkheim (2019); Violeta Hemsy de Gainza (2009); Pereira & Vasconcelos (2007); Ana Mae Barbosa (2023) ; Chris Small (1998)  e Paulo Freire (2018), com intenção de relacionar o aporte bibliográfico às experiências da autora.
Apresentação do Dossiê Temático: Pesquisa em canto coral na atualidade
Authors: Igayara-Souza Susana Cecilia , Ramos Marco Antonio da Silva , Hauck Caiti , Sabag Munir Sabag , Oliveira Carolina Andrade
Published: September 2023

Este Dossiê Temático “Pesquisa em canto coral na atualidade”, traz os resultados de pesquisas que refletem as atuais vertentes de investigação em canto coral. O dossiê faz parte das celebrações dos 50 anos de atividade coral no Departamento de Música da Escola de Comunicações e Artes da Universidade de São Paulo.
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies
Authors: Johnson Renee , Otway Robyn , Chin Ephrem , Horvat Claire , Ohanian Monique , Wilcox Jon A.L. , Su Zheng , Prestes Priscilla , Smolnikov Andrei , Soka Magdalena , Guo Guanglan , Rath Emma , Chakravorty Samya , Chrzanowski Lukasz , Hayward Christopher S. , Keogh Anne M. , Macdonald Peter S. , Giannoulatou Eleni , Chang Alex C.Y. , Oates Emily C. , Charchar Fadi , Seidman Jonathan G. , Seidman Christine E. , Hegde Madhuri , Fatkin Diane
Published: September 2023

Background:

Variants in the
DMD
gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed.

Methods:

Genetic testing of 40 male probands with a potential X-linked genetic cause of primary DCM was undertaken using multi-gene panel sequencing, multiplex polymerase chain reaction, and array comparative genomic hybridization. Variant location was assessed with respect to dystrophin isoform patterns and exon usage. Telomere length was evaluated as a marker of myocardial dysfunction in left ventricular tissue and blood.

Results:

Four pathogenic/likely pathogenic
DMD
variants were found in 5 probands (5/40: 12.5%). Only one rare variant was identified by gene panel testing with 3 additional multi-exon deletion/duplications found following targeted assays for structural variants. All of the pathogenic/likely pathogenic
DMD
variants involved dystrophin exons that had percent spliced-in scores >90, indicating high levels of constitutive expression in the human adult heart. Fifteen
DMD
variant-negative probands (15/40: 37.5%) had variants in autosomal genes including
TTN
,
BAG3
,
LMNA
, and
RBM20
. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls.

Conclusions:

Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if
DMD
-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management.
Statistical Modeling of Monthly and Seasonal Michigan Snowfall Based on Machine Learning: A Multiscale Approach
Authors: Meng Lei , Zhu Laiyin
Published: September 2023

Snow is an important component of Earth’s climate system, and snowfall intensity and variation often significantly impact society, the environment, and ecosystems. Understanding monthly and seasonal snowfall intensity and variations is challenging because of multiple controlling mechanisms at different spatial and temporal scales. Using 65 years of in situ snowfall observation, we evaluated seven machine learning algorithms for modeling monthly and seasonal snowfall in the Lower Peninsula of Michigan (LPM) based on selected environmental and climatic variables. Our results show that the Bayesian additive regression tree (BART) has the best fitting (R2 = 0.88) and out-of-sample estimation skills (R2 = 0.58) for the monthly mean snowfall followed by the random forest model. The BART also demonstrates strong estimation skills for large monthly snowfall amounts. Both BART and the random forest models suggest that topography, local/regional environmental factors, and teleconnection indices can significantly improve the estimation of monthly and seasonal snowfall amounts in the LPM. These statistical models based on machine learning algorithms can incorporate variables at multiple scales and address nonlinear responses of snowfall variations to environmental/climatic changes. It demonstrated that the multiscale machine learning techniques provide a reliable and computationally efficient approach to modeling snowfall intensity and variability.
Modeled Multidecadal Trends of Lightning and (Very) Large Hail in Europe and North America (1950–2021)
Authors: Battaglioli Francesco , Groenemeijer Pieter , Púčik Tomáš , Taszarek Mateusz , Ulbrich Uwe , Rust Henning
Published: September 2023

We have developed additive logistic models for the occurrence of lightning, large hail (≥2 cm), and very large hail (≥5 cm) to investigate the evolution of these hazards in the past, in the future, and for forecasting applications. The models, trained with lightning observations, hail reports, and predictors from atmospheric reanalysis, assign an hourly probability to any location and time on a 0.25° × 0.25° × 1-hourly grid as a function of reanalysis-derived predictor parameters, selected following an ingredients-based approach. The resulting hail models outperform the significant hail parameter, and the simulated climatological spatial distributions and annual cycles of lightning and hail are consistent with observations from storm report databases, radar, and lightning detection data. As a corollary result, CAPE released above the −10°C isotherm was found to be a more universally skillful predictor for large hail than CAPE. In the period 1950–2021, the models applied to the ERA5 reanalysis indicate significant increases of lightning and hail across most of Europe, primarily due to rising low-level moisture. The strongest modeled hail increases occur in northern Italy with increasing rapidity after 2010. Here, very large hail has become 3 times more likely than it was in the 1950s. Across North America trends are comparatively small, apart from isolated significant increases in the direct lee of the Rocky Mountains and across the Canadian plains. In the southern plains, a period of enhanced storm activity occurred in the 1980s and 1990s.
West-WRF 34-Year Reforecast: Description and Validation
Authors: Cobb Alison , Steinhoff Daniel , Weihs Rachel , Delle Monache Luca , DeHaan Laurel , Reynolds David , Cannon Forest , Kawzenuk Brian , Papadopolous Caroline , Ralph F. M.
Published: September 2023

This study presents a high-resolution regional reforecast based on the Weather Research and Forecasting (WRF) Model, tailored for the prediction of extreme hydrometeorological events over the western United States (West-WRF) spanning 34 cool seasons (1 December–31 March) from 1986 to 2019. The West-WRF reforecast has a 9-km domain covering western North America and the eastern Pacific Ocean and a 3-km domain covering much of California. The West-WRF reforecast is generated by dynamically downscaling the control member of the Global Ensemble Forecasting System (GEFS) v10 reforecast. Verification of near-surface temperature, wind, and humidity highlight the added value in the reforecast relative to GEFS. Analysis of geopotential height indicates that West-WRF reduces the bias throughout much of the troposphere during early lead times. The West-WRF reforecast also shows clear improvement in atmospheric river characteristics (intensity and landfall) over GEFS. Analysis of mean areal precipitation (MAP) shows that at the basin scale, the reforecast can improve MAP relative to GEFS and reveals a consistent low bias in the reforecast for a coastal watershed (Russian) and a high bias observed in a Northern Sierra watershed (Yuba). The reforecast has a dry bias in seasonal precipitation in the northern Central Valley and Coast Mountain ranges, and a wet bias in the Northern Sierra Nevada, consistent with other operational high-resolution (<25 km) regional models. The applications of this high-resolution multiyear reforecast include process-based studies, assessment of model performance, and machine learning applications.
Obsessions And Compulsions: A Lifespan Perspective
Authors: Rizzolo Gregory
Published: September 2023

Freud traced the origin of the obsessional neurosis, which he considered a model condition for psychoanalytic inquiry, to a fixation in the anal phase of psychosexual development. Although many analysts have raised doubts about his account, and while the Sullivanian and Lacanian traditions have proposed alternatives, no approach has accounted for what Freud observed as the dizzying variety of obsessive presentations, which seem to defy a singular explanation. The broader research community has moved on, meanwhile, to genetic, neurological, and cognitive-behavioral explanations of what we now call obsessive-compulsive disorder. I argue that we can best account for the variety of obsessive presentations and meaningfully contribute to this interdisciplinary dialogue by framing obsessive-compulsive symptoms as the result of a disorder of volition, an exaggerated sense of willpower, not tied to any one developmental phase or bodily zone. Such a disorder evolves through the lifespan processes of introjection, identification, and repudiation in relation to an anxious/critical parent or an unpredictable environment. I trace these processes through three major developmental milestones. The implication is that, by looking in depth at how the obsessive person internalizes relationships, psychoanalysis can make a unique contribution to a conversation beyond its own borders.
Pain Prevalence and Treatment in Hospitalized Children and Adolescents at a US Tertiary Pediatric Hospital
Authors: De Souza Elizabeth , Parvathinathan Gomathy , Anderson T. Anthony
Published: September 2023

Poorly controlled acute pain is associated with worsened patient outcomes. Prior studies suggest that acute pain is a common complaint among hospitalized pediatric patients, but recent studies with substantial numbers of patients from US hospitals are lacking. We retrospectively reviewed inpatients at a single academic children’s hospital during twelve 24-hour periods in 2021. Outcomes were assessed for patients on non–intensive care unit (ICU) inpatient floors and in ICUs. The primary outcome was any presence of moderate to severe pain. Of 1355 patients on a non-ICU inpatient floor and 485 patients in the ICU, 23.5% and 58.6%, respectively, had ≥1 moderate to severe pain score during the 24-hour analysis period. While the mean pain score was low for the majority of patients, moderate to severe pain is frequent in hospitalized children. Future studies may focus on identification of variables associated with pediatric inpatients at risk of moderate to severe pain as well as improved pain prevention and reduction strategies.
Book review: Susheela Kaushik, Panchyati Raj in Action: Challenges to Women’s Role
Authors: Kumar Vivek
Published: September 2023

Susheela Kaushik, Panchyati Raj in Action: Challenges to Women’s Role. FES Publication, 1995, ₹1,199. ISBN: 81-440-016-8.
Guiding Digital Transformation and Collaborative Knowledge Creation in the Pharmaceutical Supply Chain Through Action Research
Authors: Farinelli Marco , Canterino Filomena , Caniato Federico
Published: September 2023

Digital transformation initiatives in supply chain require a sector-level approach, involving multiple stakeholders. This implies the development of new models for successful implementation that move beyond the dyadic relationship level and that fosters collaboration mechanisms in multi-stakeholder and multi-level systems. This study applies an insider action research approach to the implementation of the EU system for product traceability in the pharmaceutical supply chain, the EU falsified medicines directive, focusing on stakeholder orientation's alignment. The study identifies how to overcome obstacles to the effective governance of multi-stakeholder digital transformation in supply chains. It proposes new pre-cycle and monitoring mechanisms to use in AR, highlighting the importance of formal structures to foster informal governance and relationships among different stakeholders and introducing the notion of deliberative capacity. Practical implications for managers of companies and organizations at different levels of the supply chain are discussed, illustrating the practical outcomes of the pan-European project.
Thermocouple based process optimization for laser assisted automated fiber placement of CF/LM-PAEK
Authors: Brandt Lars , Deden Dominik , Harig Jonas , Fischer Frederic , Kupke Michael
Published: September 2023

Self-commitments and increasing legal requirements lead to the compulsion to reduce carbon dioxide emissions in commercial aerospace. One viable approach is the reduction of structural mass, that would reduce emissions for every flight. This is especially true for high cadence singe aisle aircrafts. However, high quantities are required in this segment. To achieve these goals the newly developed low-melt Poly-Aryl-Ether-Ketone (LM-PAEK), a high-performance carbon fiber-reinforced thermoplastic composite was chosen to build a full-scale multi-functional fuselage demonstrator (MFFD) in order to delevelop an automated process that shows these savings. Single-step automated Fiber Placement (AFP) with in-situ consolidation offers distinct advantages in this field with its short curing times and especially by eliminating high amounts of waste otherwise caused by vacuum bagging and related tasks for post-consolidation in an autoclave. In order to ready this technology for future aircraft production this paper demonstrates how the processing window for LM-PAEK tape (TC1225) provided by TORAY was established. By closely linking robot and end-effector data with positionally accurate thermocouple measurements, the determined mechanical properties at coupon level and micro-sections of the manufactured specimens can be precisely correlated. This holistic approach is independent of the placement equipment and may enable global comparability within the community working in the field of thermoplastic AFP. In conclusion the procedure is evaluated and possible simplifications are discussed.
Machine learning and regression analysis for age estimation from the iliac crest based on computed tomographic explorations in an Indian population
Authors: Warrier Varsha , Shedge Rutwik , Garg Pawan Kumar , Dixit Shilpi Gupta , Krishan Kewal , Kanchan Tanuj
Published: September 2023

Age estimation constitutes an integral parameter of identification. In children, sub-adults, and young adults, accurate age estimation is vital on various aspects of civil, criminal, and immigration law. The iliac crest presents as a suitable age marker within these age cohorts, and the modified Risser method constitutes a relatively novel and unexplored method for iliac crest age estimation. The present study attempted to ascertain the applicability of this modified method for age estimation in the Indian population, an aspect previously unexplored, through computed tomographic examination of the iliac crest. Computed tomography scans of consenting individuals undergoing routine examinations of the pelvis/ abdomen for various clinically indicated reasons were collected and scored using the modified Risser stages. Computed tomographic examinations of the iliac crest indicate that the recalibrated method accurately depicts the temporal progression of ossification and fusion changes. Different regression and machine learning models were subsequently derived and/or trained to evaluate the accuracy and precision associated with the method. Amongst the ten regression models derived herein, compound regression exhibited the lowest inaccuracy (4.78 years) and root mean squared error values (5.46 years). Machine learning yielded further reduced error rates, with decision tree regression achieving inaccuracy and root mean squared error values of 1.88 years and 2.28 years, respectively. A comparative evaluation of error computations obtained from regression analysis and machine learning illustrates the statistical superiority of machine learning for forensic age estimation. Error computations obtained with machine learning suggest that the modified Risser method is capable of permitting reliable age estimation within criminal and civil proceedings.
Room to Improve: An Audit of In-Hospital End-of-Life Care for Oncology Patients in a Tertiary Cancer Centre in Ireland During the COVID-19 Pandemic
Authors: Carroll Hailey K. , Broderick Aoife , McCarthy Orfhlaith , Bambury Richard M. , Power Derek G. , Collins Dearbhaile C. , Connolly Roisin M. , Noonan Sinead A. , Collins Dan , Cunningham Elaine , Kennedy Mary , O'Driscoll Kieron , Nuzum Daniel , Twomey Katie , O'Riordan Aideen , O'Sullivan Finola , Roe Claire , Lowney Aoife C. , O'Leary Mary Jane , O'Reilly Seamus
Published: September 2023

The COVID-19 pandemic compounded isolation for patients through social distancing measures and staff shortages. We were concerned about the impact of COVID-19 on the quality of care provided at end-of-life in 2021 in a national cancer centre, and instigated the first ever review of the care of the dying. Quality of care was assessed retrospectively using a validated instrument developed by the United Kingdom’s National Quality Board. Sixty-six patient deaths occurred in our cancer centre in 2021. The ‘risk of dying’ was documented in 65.2% of records. Palliative care services were involved in 77%, and pastoral care in 10.6%. What was important to the patient was documented in 24.2%. The ‘quality-of-death’ score was satisfactory for most but poor in 21.2%. Our study prompted change, including appointment of an end-of-life coordinator, development of a checklist to ensure comprehensive communication, expansion of the end-of-life committee to include junior doctors, and regular audit.
A numerical investigation on indoor air ventilation design and aerosol transportation: a case study in a hospital hall
Authors: Yang Hongxin , Luo Xue , Chen Bin , Xie Heping , Huang Li , Shi Qiangqiang , Zhang Yuan , Ni Meng
Published: September 2023

The transportation of indoor aerosol particles is closely related to the infection risk of various viruses. When the pandemic of COVID-19 is anticipated to coexist with human beings in the future, the design of airflow distribution in public buildings becomes more vital not only for thermal comfort but also for epidemic prevention through controlling indoor aerosol transportation. In this paper, the conditioning of indoor air in a hospital hall (Chongzhou Traditional Chinese Medicine Hospital in Chengdu, China) is case studied by numerically simulating the indoor thermal comfort and the aerosol transportation process analysis. Simulation results indicate that thermal comfort can be first achieved by appropriate air supply forms in summer. Under the combined operation of the nozzles, square diffusers, and the breathing plane, with an average velocity of 0.26 m/s, the average temperature, and the average air age are 23.43°C and 949.59 s, respectively. Second, the arrangement of air-exhaust outlets in this hospital hall is also redesigned and simulated with three new schemes of outlets design, of which the floor exhaust scheme is optimal with the fastest aerosol discharge speed (thus the strongest pollutant discharge capacity), i.e., 62% of aerosol particles discharged in 30 s and 99% of particles discharged in 150 s. This study makes a successful attempt to optimize indoor air ventilation for preventing airborne transmission of viruses, e.g., COVID-19, offering a feasible scheme for the air distribution design in densely populated areas such as hospital halls.
Examining Teacher Leadership in the United States: How do BIPOC Teachers and White Teachers in Urban Environments Experience Shared Leadership?
Authors: Wiens Peter D. , Calkins Leona , Skousen Jacob D.
Published: September 2023

This study, using data from the American Teacher Panel survey given by the RAND corporation in 2017, examined teachers’ experiences with teacher leadership (TL) in the United States. Geographic features like urbanicity and teacher demographic characteristics were used to predict different components of TL. Black, Indigenous, and people of color (BIPOC) teachers reported lower levels of principal leadership quality, teacher influence, and shared decision-making; however, they reported higher teacher agency than their white colleagues. Similarly, teachers in schools with populations that were majority low-income and BIPOC reported lower levels of principal leadership quality, teacher influence, and shared decision-making.
Case report of scrub typhus with bilateral acute sensorineural hearing loss and cerebral salt-wasting disease
Authors: Goonetilleke Asitha , Silva Shehan
Published: September 2023

Scrub typhus is a re-emerging and endemic disease in the Asia Pacific region caused by Orientia tsutsugamushi. We present a 65-year-old male from Sri Lanka who presented with fever, bilateral acute sensorineural hearing loss, and confusion. On examination, he was dehydrated. Significant orthostatic hypotension and an eschar were noted. Investigations revealed hyponatraemia with elevated urine sodium, reduced serum osmolality, and normal urine osmolality suggestive of cerebral salt wasting. After initial hydration with 0.9% NaCl, hyponatraemia was corrected with 3% NaCl. Oral doxycycline was prescribed, and he showed dramatic clinical improvement. A diagnosis of typhus must be considered in a patient presenting with a febrile illness and acute hearing loss. Cerebral salt-wasting disease should be considered in a patient with typhus who develops hyponatraemia with dehydration. Furthermore, acute sensorineural hearing loss in both ears is an important manifestation of the disease.
Muslims leaving Islam for Jesus
Authors: Larson Warren F.
Published: September 2023

This article discusses the chaos Muslims are experiencing all over the world and suggests that in some cases Islam is imploding. Strife and violence exist between ethnic/religious factions and brutal blasphemy laws are increasing. Floundering economies, refugees on the run, women leading protests, and Islamic radicals wreaking havoc fill the news. Amid great instability, some are leaving Islam as atheists, secularists, or nones, but many are finding their way to Christ. Building on the author’s personal research on how extremist Islam has caused some Pakistani Muslims to come to Christ, this study suggests a similar pattern in Iran, Afghanistan, and beyond. The author believes we are seeing the beginning of a great harvest among Muslims, but that Christians need fresh vision and special commitment to reach them with the gospel.
“I Remember My First Relaxer”: Black Women Voicing Psychologically Engrained Practices of Chemical Hair Straightening
Authors: Mbilishaka Afiya M. , Hudlin McKalah
Published: September 2023

Chemical hair straightening is a statistical norm for Black girls and women, but due to the toxic combinations of chemicals in these products, many Black girls suffer from hair damage, breakage, and loss during a critical stage of identity development. The existing psychological interpretation of hair straightening centralizes self-hatred without accounting for the complex psycho-social impetus as told through the stories of Black women. Using the Guided Hair Autobiography, researchers elicited and analyzed the narratives of 38 Black women who underwent chemical hair straightening during their youth. Achieving “manageable” hair, community belongingness, and maternal choice were the identified reasons for chemically straightening hair. Both physical harm and psychological conflict were consequences of this beauty practice. These narrative insights offer clinicians a critical context for the role of early memories in body image and family dynamics. This study highlights the role of chemical hair straightening embedded into the identities of Black women, complicates the internalized narratives of racialized embodied aesthetics, and invites deeper examination of toxic beauty practices in Black female relationships and identity development.
Toward an Upgrade of Gaia-politics: A View from the East Asian Critical Zone
Authors: Jobin Paul , Chen Tzung-Wen
Published: September 2023

Although Bruno Latour had limited interaction with East Asia, translations of his work contributed to the development of Science and Technology Studies (STS) in that part of the world. More recently, Latour’s curation of the Taipei Biennial with STS participation offered a stimulating path for what he framed as Gaia-politics: a reset of modern geopolitics and territories centered on the climate emergency and ecological/terrestrial attachments. The exhibition’s locus in Taiwan was an important element in this, through its position as a hot spot of the Critical Zone—that thin layer of the Earth most sensitive to climate change. Latour’s approach to political ecology has, however, been criticized for a lack of attention to the role of capitalism in what led to the current climate upheaval. While we partly agree with this criticism, we are more concerned that the current version of Gaia-politics neglects the importance of nation-states and traditional sovereignties in handling the climate emergency. We argue that an upgrade of Gaia-politics is required to also address the resurgence of aggressive authoritarian regimes as well as the double threat of climate “wars” and traditional warfare.
Transcranial Direct Current Stimulation and Brain–Computer Interfaces for Improving Post-Stroke Recovery: A Systematic Review and Meta-Analysis
Authors: Lima Eloise de Oliveira , Silva Letícia Maria , Melo Ana Luísa Vilar , D’arruda Julia Vitória Torres , Alexandre de Albuquerque Marlon , Ramos de Souza Neto José Maurício , Araújo de Oliveira Eliane , Andrade Suellen Marinho
Published: September 2023

Objective

This study aimed to evaluate the effectiveness of transcranial direct current stimulation associated with brain–computer interface in stroke patients.

Data sources

The PubMed, Central, PEDro, Web of Science, SCOPUS, PsycINFO Ovid, CINAHL EBSCO, EMBASE, and ScienceDirect databases were searched from inception to April 2023 for randomized controlled studies reporting the effects of active transcranial direct current stimulation associated with brain–computer interface to a transcranial direct current stimulation sham associated with brain–computer interface condition on the outcome measure (motor performance and functional independence).

Review methods

We searched for full-text articles which had investigated the effect of transcranial direct current stimulation associated with brain–computer interface on motor performance in the upper extremities in stroke patients. The standardized mean differences derived from the change in scores between pretreatment and post-treatment were adopted as the effect size measure, with a 95% confidence interval. Possible sources of heterogeneity were analyzed by performing subgroup analyses in order to examine the moderating effects for one variable: the level of injury severity.

Results

Nine studies were included in the qualitative synthesis and the meta-analysis. The findings of the conducted analyses indicated there is not enough evidence to suggest that active transcranial direct current stimulation associated with brain–computer interface is more efficient in motor performance and functional independence when compared to sham transcranial direct current stimulation associated with brain–computer interface or brain–computer interface alone. In addition, the quality of evidence was rated very low. A subgroup analysis was performed for the motor performance outcome considering the injury severity level.

Conclusion

We found evidence that transcranial direct current stimulation associated with brain–computer interface was not more beneficial than sham transcranial direct current stimulation associated with brain–computer interface or brain–computer interface alone.