bluuebunny/crossref_metadata_2025 huggingface dataset:
EXPLANATION OF “ORDER” AND “CHAOS” THROUGH “SEQUENCES”: ABSTRACT THINKING IN BASIC DESIGN EDUCATION
Authors: SHEIBANIAGHDAM Daniz , ZENGİN Gözde , HAJİAMİRİ Milad
Published: June 2023

This study aimed to demonstrate high potential in using mathematics to facilitate the transmission of

design principles in basic design education. It provided an example of how students’ previous mathematical

knowledge could be utilized to assist them in understanding the initial design principles. In this respect,

“sequence” as a mathematical concept was used to explain the concepts of “order” and “chaos” to the first-year

industrial design students who had basic mathematics knowledge. The case was studied as part of a workshop

in which students from a Karabuk University's basic design studio participated. As part of the workshop’s

theme, waste materials were utilized in the design process. The purpose of this study was to provide a teaching

method for improving the dialog between teachers and students in basic design studio without providing

existing examples which can interfere the learning process and limit or hinder the students’ creativity. A

similar methodology can be developed based on other mathematical concepts in order to clarify and teach

design principles in the future.
DOĞADAN İLHAM ALAN ÇEVRE DOSTU TASARIMLAR İÇİN BİR POTANSİYEL OLARAK LYOCELL LİFLERİ VE DOĞAL BOYALAR
Authors: ÖZEN Özge , ERDEM İŞMAL Özlenen
Published: June 2023

Bu deneysel çalışmada, çevre dostu bir lif olan lyocell kumaşın renklendirilmesi için, çeşitli bitkiler ve

bitkisel atıklardan elde edilen doğal boyar maddeler ile birlikte düşük miktarlarda mordan maddeleri

kullanılarak, sürdürülebilirlik ve eko tasarım bağlamında doğal boyamacılığa dikkat çekilmiştir. Çevre dostu

rejenere selülozik esaslı bir lif olan lyocell kumaşın çeşitli bitkiler ve bitkisel atıklarla boyanma özellikleri

incelenerek bir renk paleti oluşturulmuştur. Kaynakçada lyocell lifinin doğal boyalarla renklendirilmesiyle

ilgili az sayıda çalışma bulunmaktadır. Bademin dış yeşil kabuğu, pirina, ceviz kabuğu, soğan kabuğu, nar

kabuğu, zerdeçal, kök boya, biberiye ve tarçın gibi doğal boyar madde kaynakları, potasyum alüminyum

sülfat (şap), demir II sülfat, bakır II sülfat mordan maddeleri ile birlikte ön mordanlama yöntemine göre

boyamada kullanılmışlardır. Genel olarak şap ve bakır II sülfat mordanları ile birbirine yakın tonlar, demir

II sülfat mordanı ile en koyu renkler elde edilmiş, doğal boya cinsine bağlı olarak renk tonlarının değiştiği

gözlemlenmiştir. Sarı, turuncu, bej, açık pembe, gülkurusu, yağ yeşili, kahverengi, toprak, kimyon renkleri

ve tonları elde edilmiştir. Soğan kabuğu, kök boya ve tarçın ile yapılan boyamalarda mordanlar arasında

önemli derecede renk tonu farklılıkları olduğu tespit edilmiştir. Görsel kıyaslamanın yanı sıra renk ölçümleri

ve yıkama haslık özellikleri değerlendirilmiştir. Mümkün olan en az mordan ve boyar madde miktarları

kullanılarak oldukça geniş bir renk paleti ve yıkama haslık değerleri 4-5 olarak elde edilmiştir
CULTURAL HERITAGE KALEVALA; RAIJA UOSIKKINEN AND HER ILLUSTRATIONS
Authors: SALUR Nilgün
Published: June 2023

Throughout history, illustration has been a visual language and communication tool in different countries

and cultures of the world. The illustration technique has played an important role in the transmission of

literary texts, heroic stories, and mythological transmissions.

This article discusses the contribution of artist Raija Uosikkinen as a designer and illustrator for Arabia, one

of the most well-known ceramic factories in Finland, for nearly 40 years. In addition, the article touches

upon the 24 limited edition plate designs produced annually for Finland’s natioanl epic, Kalevala, from 1976

to 1999. In addition, the article examines the artist’s original illustration style and screen printing technique

in creating designs based on poetic stories of both real and prehistoric gods, goddesses and heroes. The

article highlights the quality of plate illustrations in this series, which combine folkloric elements with a

contemporary interpretation of poetic text, as documenting cultural heritage through an epic. Based on this

information, the article describes the designs from 1976 and 1999, featuring Uosikkinen illustrations on the

front and a part of the Kalevala epic in Finnish, Swedish and English on the back.
COVİD-19 PANDEMİSİNİN EĞİTİM MEKÂNI KULLANIMINA ETKİLERİ: KTÜ MİMARLIK FAKÜLTESİ BİNASI ÖRNEĞİ
Authors: MİDİLLİ SARI Reyhan , ŞAHİNER TUFAN Ayşe
Published: June 2023

Covid-19 salgını her şeyi etkilediği gibi insanın mekânla olan ilişkisini de etkilemiştir. Yeni normalde

kalabalık mekân kullanımlarını azaltmak amacıyla bazı geçici önlemler alınmıştır. Ancak bu salgının

etkileri ve yeni salgınlarla yaşama ihtimalinin korkusu uzun yıllar devam edecektir. Bu noktada, atölye ve

grup çalışmaları nedeniyle yakın temas halinde olmayı gerektiren bölümlerde öğrencilerin eğitim aldıkları

mekânlar için kapsamlı ve kalıcı çözümlere ihtiyaç duyulmaktadır. Bu bağlamda çalışmanın amacı; tasarım

ağırlıklı bölümlerde pandemi öncesi süreci de göz önünde bulundurarak pandemiye bağlı değişen mekânsal

ihtiyaçları ortaya koymaktır. Bu süreçte öğrencilerin en sık kullandığı atölye ve geçiş mekânlarının kullanıcı

deneyimine bağlı olarak mekân kullanımı açısından değerlendirilmesi ve eğitime yardımcı mekânların

pandemi sürecindeki işlevsel değişiminin tespiti çalışmanın önemini ortaya koymaktadır. Nitel araştırma

deseninde tasarlanan çalışmada odak grup görüşmesi ile elde edilen veriler betimsel yolla analiz edilmiştir.

Görüşmeler KTÜ Mimarlık ve İç Mimarlık Bölümü öğrencileriyle gerçekleştirilmiştir. Çalışmanın sonucunda

pandemiye bağlı olarak mekân kullanım sürelerinin azaldığı, mekân kullanım amaçlarının değiştiği, akran

öğrenmesinin bu süreçten olumsuz etkilendiği ve pandemi öncesi süreçte var olan fiziksel problemlerin

pandemi sonrasında daha da görünürlük kazandığı tespit edilmiştir.
Immune checkpoint inhibitors in ovarian cancer: where do we go from here?
Authors: Yoon Won-Hee , DeFazio Anna , Kasherman Lawrence
Published: June 2023

Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy, and despite advancements in therapeutics, most women unfortunately still succumb to their disease. Immunotherapies, in particular immune checkpoint inhibitors (ICI), have been therapeutically transformative in many tumour types, including gynaecological malignancies such as cervical and endometrial cancer. Unfortunately, these therapeutic successes have not been mirrored in ovarian cancer clinical studies. This review provides an overview of the ovarian tumour microenvironment (TME), particularly factors associated with survival, and explores current research into immunotherapeutic strategies in EOC, with an exploratory focus on novel therapeutics in navigating drug resistance.
Improved vanishing point reference detection to early detect and track distant oncoming vehicles for adaptive traffic light signaling
Authors: Syahbana Yoanda Alim , Zulherman Dodi , Yasunari Yokota
Published: June 2023

Real-time traffic monitoring is essential for the operation of an adaptive traffic lighting system and plays a significant role in decision-making, particularly signaling in roadworks. When only one lane is accessible due to temporary road blockage, early detection of oncoming vehicles is crucial to minimize bottlenecks near the traffic light that could result in congestion and accidents. This research aimed to enhance the detection and tracking of traffic at a distance from the traffic light. We utilized the vanishing point as a reference for detection and calculated the region of interest. We implemented the proposed method on twelve traffic surveillance videos and evaluated the system performance based on how quickly it could detect incoming traffic compared with the R-CNN method. The proposed method detected target vehicles in an average of 17.75 frames, while the R-CNN method required an average of 63.36 frames. Moreover, the proposed method’s precision depends on the number of pixel orientations used to estimate the vanishing point and the definition of the region of interest. Therefore, the proposed method for enhancing the safety and reliability of an adaptive traffic light system is reliable.
Condiciones de trabajo y prácticas con plaguicidas en trabajadores de control de vectores en México
Authors:   Escuela de Salud Pública de México/Instituto Nacional de Salud Pública, Morales-Galindo Edmundo , Blanco-Muñoz Julia ,   Centro de Investigaciones en Salud Poblacional. Instituto Nacional de Salud Pública, Arenas-Monreal Luz ,   Escuela Superior de Tlahuelilpan. Universidad Autónoma del Estado de Hidalgo, Hernández Mariano José Ángel ,   Escuela Superior de Tlahuelilpan. Universidad Autónoma del Estado de Hidalgo
Published: June 2023

En México se utilizan plaguicidas organofosforados, carbamatos y piretroides en el programa de manejo de enfermedades trasmitidas por Aedes aegypti, por lo que los trabajadores que laboran en dichos programas como fumigadores constituyen una de las poblaciones con mayor riesgo de exposición ocupacional a estos compuestos. El objetivo de este estudio fue analizar las condiciones de trabajo que incrementan la oportunidad de exposición a plaguicidas en el personal responsable del control del mosquito adulto A. aegypti en Morelos y cómo aquéllas moldean las prácticas de estos trabajadores. Se llevó a cabo un estudio cualitativo en 68 trabajadores de los Servicios de Salud de Morelos adscritos al programa de control de vectores. La información sobre condiciones de trabajo, percepción y prácticas de riesgo se obtuvo mediante grupos focales y registro etnográfico durante abril y mayo del 2014. De acuerdo con la información obtenida, el contexto de trabajo y las condiciones laborales precarias modulan las conductas de riesgo en el manejo de plaguicidas al representar barreras concretas que dificultan la adopción de medidas de seguridad. Los resultados de este estudio muestran la importancia de generar condiciones laborales destinadas a reducir la oportunidad de exposición a plaguicidas en el personal de salud que realiza tareas de control químico de enfermedades transmitidas por vector.
Vitamin C Modifies the Phenotype of Hormone Receptor Positive/HER2 Negative Breast Cancer Cells and Induces Changes in Sphingolipid Metabolism
Authors: Codini Michela , Fiorani Federico , Mandarano Martina , Cataldi Samuela , Arcuri Cataldo , Mirarchi Alessandra , Ceccarini Maria Rachele , Beccari Tommaso , Kobayashi Toshihide , Tomishige Nario , Sidoni Angelo , Albi Elisabetta
Published: June 2023

The effect of the antioxidant vitamin C in cancer has been studied for over 30 years with conflict-ing results ranging from total absence of effect, to possible protective effect, to potential therapeutic effect when administered in high doses. The aim of the study was to define the effect of vitamin C in breast cancer and the possible involvement of sphingomyelin metabolism. Therefore, the effect of low and high dose of vitamin C on cells reproducing luminal A type (MCF7) and triple negative type (MB231) of breast cancer was analyzed. The results showed that high dose of vitamin C produced effects only in MCF7 cells such as decreased cell viability, modulation of cell cycle re-lated genes, unexpected change in cell phenotype due to estrogen receptor downregulation, catabo-lism of sphingomyelin with a large increase in ceramide.
In conclusion, we demonstrated that high doses of VitC on the one hand reduce the growth of lu-minal A type breast cancer cells and on the other hand induce their phenotypic change towards hormone therapy resistant cells. The effect of vitamin C on therapeutic treatment failure of luminal A breast cancer and the possible involvement of high ceramide levels were discussed.
Diabetic Retinopathy and the Extracellular Vesicles.
Authors: Dharmalingam Kuppamuthu , Ramasamy Kim
Published: June 2023

Diabetes and diabetes-induced micro and macrovascular complications are major causes of healthcare problems. The extracellular vesicles are produced by all cells from all organisms. They are shown to have properties of the producer cells and also reflect the host physiology and pathology. Since the EVs represent the cellular state they are excellent biomarkers. In this review, we will focus on the EVs produced by the Neuro Vascular Unit cells of the eye as well as the extraocular cells in the onset and progression of diabetic retinopathy. A brief account of the use of these nanovesicles in personalised medicine is also given.
Target Selection Strategies for Demucs-Based Speech Enhancement
Authors: Rascon Caleb , Fuentes-Pineda Gibran
Published: June 2023

Online speech enhancement is of great interest, because of its diverse areas of application. The Demucs architecture has been recently shown to achieve a high level of performance, even with small audio segments, while requiring a relatively small amount of computational resources. However, an issue that it bears, as well as most of state-of-the-art speech enhancement techniques, is that of target speech selection: it is assumed that only one speech source is present. However, in real-life scenarios, more than one speech source may be present, in it is uncertain which speech source within the fed mixture should be enhanced. Thus, it is of interest to complement speech enhancement techniques (such as Demucs-based) with a target selection scheme, so as to ensure that only the source of interest is enhanced. In this work, two target selection strategies are explored: 1) an embedding-based strategy, using a codified sample of the target speech, and 2) a location-based strategy, using a beamforming-based pre-filter to select the target that is in front of a 2-microphone array. It is shown that while both strategies improve the performance of the Demucs-based technique when one or more speech interferences are present, they both have their pros and cons. Specifically, while the beamforming-based strategy achieves overall a better performance compared to the embedding-based strategy, it is sensitive against the location variation of the target speech source which the embedding-based strategy does not suffer from.
Lived Experiences of Teachers with Workplace Violence and Harassment Committed by Learners from Selected High Schools in Limpopo Province, South Africa
Authors: Mangena Madie Collen , Matlala Sogo France
Published: June 2023

Despite several studies on learner-to-teacher workplace violence and harassment, the problem persists in some South African schools. Learner-to-teacher violence and harassment is a form of workplace violence and harassment as schools are workplaces for teachers. Learner-to-teacher violence and harassment is therefore an important occupational health and safety issues for teachers. The employer is obliged to provide a safe working environment for the teachers to enable quality teaching and learning in the schools. The purpose of this interpretative phenomenological study was to explore and describe the lived experiences of high school teachers who have been targets of workplace violence and harassment perpetrated by learners at selected schools in Limpopo province of South Africa. Many teachers were willing to share their lived-experiences but due to data saturation, only eleven participated after being selected through purposive sampling from seven high schools under a particular circuit. Research ethics of voluntary participation, informed consent, ethical clearance and gatekeeper permission were observed. Data was collected through semi-structured interviews using an interview guide. Interviews were audio-taped, and field notes were also taken. Voice recordings were transcribed verbatim and analysed using interpretative phenomenological analysis into themes and sub-themes. Findings were confirmed by an independent coder to achieve trustworthiness. Teachers experienced physical workplace violence and harassment, verbal workplace violence and harassment as well as nonverbal workplace violence and harassment from learners. Learner-to-teacher workplace violence and harassment affects teachers emotionally and in turn affects quality teaching and learning in the schools. Some teachers propose involvement of community policing forum, strengthening of School Governing Bodies as well as reducing overcrowding in the classroom as possible solutions to deal with learner-to-teacher bullying.
Oral Health-Related Status and Exercise Performance: A Study From High- and Elite-Level Athletes
Authors: Cardoso Filipa , Sampaio António R. , Vilas-Boas João Paulo , Pinho João Carlos , Pyne David B. , Fernandes Ricardo J.
Published: June 2023

Oral health involves physiological functions related to mouth, teeth and orofacial structures, but also includes psychological and social dimensions. In this sense, oral health is an integrated part of human general health and well-being. Our aim was to access and evaluate the general oral health status of a high- and elite-level sample of Portuguese athletes from different sports. One hundred and sixteen participants were examined regarding their dental relationships, teeth and periodontal health, the presence of parafunctional activities (bruxism), and current or past orthodontic treatment. Our sample were predominantly adolescents and young adults, including 54 high-level and 62 elite subjects (71 males and 45 males) from 11 different sports, but mainly from swimming and athletics. Most sport performers presented with normocclusion (77%), despite the presence of other sagittal, transverse and vertical malocclusions. Twenty-three participants were affected by dental caries and six had missing teeth. Gingivitis (~40%) and dental calculus (~30%) were presented in our sample. Bruxism signs (47%) and current or past orthodontic treatment (~22%) were also found. Oral health conditions are not under control among high- and elite-level athletes, supporting the importance of healthcare needs and oral health promotion strategies in sports.
Directional Crystallization of Conjugated Molecules during Coating Processes
Authors: Smilgies Detlef-M. , Li Ruipeng
Published: June 2023

Coating of organic molecules from the solution phase can result in directional crystal growth under certain conditions, even on a smooth isotropic surface and without the need of any kind of graphoexpitaxial preparation of the substrate. Based on reviewing the results from a variety of coating techniques and conditions, we identify the condition that the coating speed should equal the growth speed of the fastest growing crystal plane as crucial for achieving a high degree of directional crystallization.
Enhancing Rock Fragmentation Assessment in Mining Blasting through Machine Learning Algorithms: An Effective Approach
Authors: Gebretsadik Angesom , Kumar Rahul , Ikeda Hajime , Ali Mujahid , Fissha Yewuhalashet , Mishra Arvind Kumar , Kide Yemane , Mnzool Mohammed , Ali Enas , Gomaa E. E.
Published: June 2023

In a limestone quarry mine, fragmentation is a crucial outcome of blasting operations. The optimization of blasting operations greatly benefits from the prediction of rock fragmentation. The main factors that affect fragmentation are rock mass characteristics, blast geometry, and explosive properties. This paper is a step towards the implementation of machine learning and deep learning algorithms for predicting the extent of fragmentation (in percentage) in opencast mining. Various parameters can affect fragmentation. But, in this paper initially, ten parameters (spacing, drill hole diameter, burden, average bench height, powder factor, number of holes, charge per delay, uniaxial compressive strength, specific drilling, and stemming) are collected to train the model. However, due to a weak correlation with rock fragmentation, drill diameter, Average bench height, compressive strength, stemming, and charge per delay are eliminated to reduce model complexity. A total of 219 data sets having five input features i.e., the number of holes, spacing, burden, specific drilling, and powder factor are used to develop the models. To predict rock fragmentation due to blasting in limestone quarry mines, both machine learning models (Random Forest Regression (Bagging), Support Vector Regression, and XG Boost Regression (Boosting)), as well as a deep learning model (Neural Network Regression), are applied to develop a model that can optimize the prediction of fragmentation. The Artificial neural network model optimization showed that the model with architecture 64-32-16-1 can perform well giving MSE (mean squared error) values of 41.32 and 28.59 on training and test data respectively. The R2 value for both training and test is 0.83. Random Forest regression is also performing well compared to SVR and XG boost with the MSE value 12.37 and 9.89 on training and testing data respectively. Here, the R2 value for both sets are 94%. Based on the permutation importance and Shapely plot values, the powder factor has the highest impact, and the burden has the lowest impact on fragmentation.
A New Dialectical Model of Water Security under Climate Change
Authors: Ganoulis Jacques
Published: June 2023

The way humans use natural resources and especially freshwater, reflects their relationship with nature. It also influences the conceptual Water Resources Management (WRM) model. A historical review shows that the interplay between Humans and Nature is diachronically in constant change between two opposites: conflict and cooperation. Lessons from the past 20.000 years indicate that the WRM model is a function of two main parameters: (1) socio-economics, and (2) climate conditions. Three different Eras of the Humans-Nature relationship have been distinguished: (1) Naturalistic: Nature dominating Humans during the Last Glacial Period (100-10) kyr BC, (2) Dualistic: Nature-Humans cooperation and competition from 10 kyr BC to 1800 AD, and (3) Anthropocentric: Humans dominating Nature from 1800 AD to now. Since 2000, the Integrated WRM (IWRM) model is promoted as state-of-the-art and remains anthropocentric producing huge externalities. Its assessment during the last 20 years has given mixed results and needs to be reformulated. The new model we suggest is based on the dialectical tool for conflict resolution. It unifies Humans and Nature and enhances the social dimension of WRM. After identifying conflicts between stakeholders and the natural laws (eristic part), opposite objectives are unified to harmonize Humans with Nature (dialectical resolution). A case study of flood mitigation illustrates the eristic-dialectical methodology.
Protocol of a Rapid Method to Quantify Beta-carotene in Human Sera
Authors: Ng Yit , Tan Seok Shin , Moy Foong Ming
Published: June 2023

Beta-carotene is a fat-soluble antioxidant commonly found in foods such as fruits, vegetables, and palm oil. Despite various liquid chromatography methods are proposed to detect and measure the sera carotenoid level, a long retention time to elute this marker is needed. This study attempted to develop a rapid reverse phase method in eluding beta-carotene in human sera. The researchers managed to elute the antioxidant in 2.2 minutes by applying a combination of a C8 column, mobile phase comprising of acetonitrile mixed with methanol in 70:30 proportion, and an ultra-high performance liquid chromatography system. The outputs had a good calibration curve (R2=0.959) and low coefficient of variation (0.2%), suggesting this protocol is reliable. A column with a lower carbon chain such as C8 allows the beta-carotene molecule to flow through the column faster. Besides, selecting solvents with high elution strength coupled with an ultra-high performance liquid chromatography system which equipped with high pressure can force the beta-carotene through the column in a shorter duration compared to previous reported methods. Therefore, it is recommended to adopt this protocol in epidemiological studies where beta-carotene is screened as a dietary biomarker associated with disease of interest by using human sera in the population level.
Physicochemical Characteristics, Selected Lipid Content and Protein Bioactive Compounds of Lamb Meat Depending on Aging Time and Muscle Type
Authors: Radzik-Rant Aurelia , Rant Witold , Świątek Marcin , Sosnowiec-Wierzchoń Gabriela , Niżnikowski Roman
Published: June 2023

Many factors affect the quality of red meat. The aim of the study, carried out on 44 Polish Merino lambs, was analysis of physicochemical traits (pH, meat color, expressed juice, content of moisture, protein, fat, total collagen and fatty acid ) and content of carnosine, taurine, L-carnitine on fresh and meat aged for 7 and 14 d in the longissimus lumborum (LL) and gluteus medius (GM) muscles., Higher (p<0.05) redness value (a*), lower yellowness (b*) were recorded in meat after of aging in gluteus medius muscle. A lower value (p<0.05) of expressed juice was found in both LL and GM after 7 days of aging. The increase (p<0.05) in protein and fat content in both muscle and collagen content in LL was observed in aged meat. There was no difference in fatty acid groups and C18:2 c9, t11 content between GM and LL muscle and fresh and aging meat. A higher TBARS content (p<0.05) was recorded in meat after aging in both GM and LL. The meat aging process increased (p<0.05) the content of carnitine and taurine, while the content of carnosine decreased. In summary the processes that turn muscles into meat in different types of muscles affect the physicochemical characteristics and the content of bioactive ingredients.
Crystal Structure, Hirshfeld Surface Analysis and Energy Framework Calculations of Different Metal Complexes of a Biphenol-based Ligand: Role of Solvent and Transition Metal Ion
Authors: Macedi Eleonora , Rossi Patrizia , Formica Mauro , Giorgi Luca , Lippi Martina , Montis Riccardo , Paderni Daniele , Paoli Paola , Fusi Vieri
Published: June 2023

A new Pd(II) complex of the previously reported ligand N,N′-bis[(2,2′-dihydroxybiphen-3-yl)methyl]-N,N′-dimethylethylenediamine (L) was obtained from a DMF/H2O mixture. It differs from a Pd(II) complex of L previously obtained by sole DMF. The roles in the solid state assembly of solvent molecules and molecular conformation (driven by specific transition metal ions) were studied by comparing six complexes of L containing different metal centers (Ni(II), Cd(II), Cu(II), Pd(II)). Hirshfeld surface analysis, 2D fingerprint plots and energy frameworks calculations were used to investigate the intermolecular interactions within the crystal packing of the six complexes. As suggested by interaction energies, Pd(II) and Ni(II) complexes arrange to form ribbons, while Cd(II) and Cu(II) complexes form 3D networks. Interactions between complexes and solvent molecules in the previous Pd(II) complex are replaced by complex-complex interactions in the new Pd(II) complex, while BuOH and MeOH are interchangeable in the interactions within the crystal packing of the two Ni(II) complexes. Finally, solvent molecules are not involved in the crystal packing of the Cu(II) complex. The present study suggested that the solid state assembly of these systems is mainly driven by the molecular conformation, that depends in turn by the metal ion involved, while the solvent only plays a minor role.
Experimental Investigation on Improvement Potential of Heat Pump Equipped with Two-Phase Ejector
Authors: Singmai Wichean , Onthong Kasemsil , Thongtip Tongchana
Published: June 2023

An experimental investigation on the heat pump performance improvement equipped with the two-phase ejector called “an ejector-expansion heat pump (EEHP)” is proposed. The system performance of the EEHP is compared with a vapour-compression heat pump (VCHP). The improvement potential is determined and discussed. The heat pump test system is constructed which is based on a water-to-water heat pump. It can be experimented with both EEHP and VCHP. The two-phase ejector with the cooling load up to 2500 W is installed for experiment. The results show that the EEHP always produces a higher heating rate and COP than the VCHP throughout the specified working conditions. The heating COP is increased by 5.7-12.2% depending on the working conditions. It is also that under the same heat sink and heat source temperature, the EEHP can produce lower compressor discharge temperature and lower compressor pressure ratio than the VCHP. This is evidence that the two-phase ejector can provide better compressor working characteristics which yields a longer compressor lifetime. It is demonstrated that a key to the performance of the EEHP is the expansion pressure ratio. A larger expansion pressure ratio yields a higher improvement potential when compared with the VCHP.
Level of DNA similarity the horned and polled Bali Cattle Using Microsatellite approach
Authors: Maupa Zulkharnaim , Baco Sudirman , Rahim Lellah , Yusuf Muhammad
Published: June 2023

The phenomenon of polled on Bali cattle should have a scientific explanation that explains the validity of the breed. Whether polled Bali cattle still have a genetic relationship with horned Bali cattle or are the results of crosses with other cattle breeds. This study used microsatellite markers to identified the genetic diversity and relationship between polled and horned in Bali cattle. The number of samples of 40 polled Bali cattle and 189 Bali horned cattle. The age of the study sample was 2.5 - 3.5 years. Research data analysis includes: genotype and allele frequencies, Hardy Weinberg Equilibrium analyze, observed and expected heterozygosity values, and polymorphic informative content. Polled Bali cattle have similar morphological and genetic characteristics with horned Bali cattle based on HEL9, INRA035, ILSTS045, and HEL13 microsatellite. HEL9, INRA035, ILSTS045, and HEL13 microsatellite can be a genetic marker for polled Bali cattle.
Aflatoxin M1 in Milk: Occurrence and Its Risk Association: A Review
Authors: Sadam Suliman Mohamed Yousof , Malaka Ratmawati , Baco Sudirman , Mustabi Jamila
Published: June 2023

Aflatoxin M1 (AFM1) is the main secondary metabolites of aflatoxin B1 (AFB1) framed in the liver and discharged into milk when people and animals polish off AFB1-polluted food. The persist from feed to milk in dairy cows is affected by different dietary and physiological elements, including taking care of regimens, rate of ingestion, rate of absorption, animal health, hepatic biotransformation limit, and real milk production of the animals. AFM1 exposure might cause both intense and constant toxicity. In humans, AFM1 exposure is related with cancer-causing nature, genotoxicity, mutagenicity, and teratogenicity. In dairy animals, persistent openness to AFs can decrease execution, debilitate liver capability, compromise invulnerable capability, and increment sickness susceptibility. AFM1 openness represents a worry for the worldwide populace, especially for babies and youngsters who drink milk in bounteous amounts and thus, are more powerless to unfavorable impacts. The identification and quantification of AFs represents a critical test in food handling confirmation, since even a low AF concentration is hazardous for people and domesticated animals. Consistent human openness through dietary courses has prompted the burden of most extreme cut off points for AFM1 in milk and dairy products, taking into account that this is a gathering of products with exorbitant premium, particularly for babies and youngsters. Likewise, as per different examinations it is additionally very much felt that youthful animals are additionally observed to be more vulnerable to aflatoxin than grown-ups. Consequently; the defilement of cow milk and milk products by AFM1 ought to be perceived as unfortunate for youthful human and animals. Thus, the point of this paper is to review the occurrence of aflatoxin and its adverse results on animals and human health over the time.
ASYMMETRIC DISTRIBUTION OF PIPE ADAPTER FOR CARS
Authors: Puzyr Ruslan , Arhat Roman , Klimov Eduard , Chernenko Serhiy , Chernysh Andriy , Sira Yulia , Haikov Roman
Published: June 2023

It is shown that the responsible parts of each vehicle are tubular connecting lines, which are included into the braking, fuel and exhaust systems of cars. These pipelines have high requirements for reliability, vibration resistance, strength, corrosion resistance and durability. These parts are used as expanders and connecting elements when transitioning from a smaller pipeline diameter to a larger one. The paper presents studies of the operation of distributing the end of the pipe blank with a rigid punch. In the process of distribution, the acting tangential stresses lead to a decrease in the thickness of the edge section of the workpiece. This entails a decrease in the reliability of this area during operation and a decrease in its maintainability and corrosion resistance. Also, to ensure the tightness of pipe connections, threads are cut or these areas are welded together in the specified areas of the workpieces. Therefore, an important design feature of tubular diffusers is the same wall thickness throughout the cross-section of the semi-finished product. To solve the problem of increasing the thickness of the semi-finished product after distribution, an asymmetric tool is proposed. The task was solved in the finite-element formulation using a special complex of 3D modeling Simulia Abaqus – student edition. The pipe blank was represented as a deformable solid, while the punch was modeled as a completely rigid discrete solid. The construction method for both models is "revolution". According to finite element modeling, dispensing with a conical asymmetric tool has advantages from the point of view of increasing the thickness of the end zone of the pipe bell. The thickness of the part increases by 22.5% from a thickness of 1.77 mm for the classic version of distribution, to 1.82 mm – for distribution with an asymmetric tool. To reduce the thinning of the wall after distributing the pipe blank, it is recommended to use an asymmetric punch. To obtain a symmetrical pipe socket, it is necessary to make two dispensing transitions with a 180° rotation of the blank or punch
FORMATION OF TEST IMPACTS FOR THE FIRST LEVEL OF THE INFORMATION AND MEASUREMENT SYSTEM
Authors: Hryhorenko Ihor , Kondrashov Serhii , Opryshkin Aleksandr
Published: June 2023

The issue of increasing the efficiency of coffee grinding systems thanks to non-dismantling test control of metrological characteristics of information and measurement systems remains relevant today, despite the fact that both domestic and foreign scientists continue to deal with this issue. Test control methods are widely used in various industries, and grinding systems are no exception. In addition to the factors affecting the coffee grinding process, it is necessary to take into account the change in the metrological characteristics of both the individual components of the equipment and the information and measurement system as a whole. Since the grinding process is dynamic, it is necessary to carry out test control of the equipment without stopping work. There is a need for non-dismantling test control by forming additive and multiplicative test effects at the first level of the information and measurement system. The difficulty is that when building a mathematical model of the process, it is practically impossible to take into account dynamic changes on the object, which can be both linear and non-linear. The specified feature of the grinding process makes it necessary to move to the creation of a situational system with fuzzy logic, which can help in determining the optimal relationship between the characteristics of the technological equipment to ensure the minimum value of the dynamic error. The Mamdani fuzzy inference construction method was chosen in the work to create a situational system with fuzzy logic. This algorithm is most common when it is necessary to help a metrological engineer in making a decision. With the help of a graphical user interface, a situational system with fuzzy logic was built for the first level of the information and measurement system, which is able to determine such parameters that will ensure the minimum value of the dynamic error of the grinding system when working out the action of additive and multiplicative test effects. The use of the presented approach can be extended to the class of problems of determining the optimal ratio between disparate parameters to obtain the best result.
Kepuasan Keuangan pada Generasi Sandwich dan Implikasinya terhadap Perilaku Mengelola Keuangan
Authors: Nurul Khasanah  , Umi Widyastuti  , Muhammad Fawaiq
Published: June 2023

ABSTRACT

Financial satisfaction is determined by circumstances and understanding of personal financial needs. This research analysis is needed to investigate the determinants of financial satisfaction in the sandwich generation and their implications for financial management behavior. This research is quantitative and causal. Data collection was carried out through a research survey conducted in Greater Jakarta using an online questionnaire which was distributed via social media and involved one hundred and twenty five generations of sandwiches. The research findings show that financial literacy has a positive and significant effect on financial management behavior and financial satisfaction. The hypothesis is rejected where financial attitudes do not affect financial management behavior and financial satisfaction. Financial management behavior has a positive and significant effect on financial satisfaction in the sandwich generation.

Keyword: financial management behavior, financial satisfaction, sandwich generation

 

ABSTRAK

Kepuasan keuangan ditentukan oleh keadaan dan pemahaman akan kebutuhan finansial pribadinya. Maka, analisis penelitian ini diperlukan untuk menyelidiki faktor-faktor penentu kepuasan keuangan pada generasi sandwich dan implikasinya terhadap perilaku mengelola keuangan. Penelitian ini bersifat kuantitatif dan kausal. Pengumpulan data dilakukan melalui survei penelitian yang dilakukan di Jabodetabek dengan menggunakan kuesioner online yang disebarkan melalui media sosial dan melibatkan seratus dua puluh lima generasi sandwich. Temuan penelitian menunjukkan bahwa literasi keuangan berpengaruh positif dan signifikan terhadap perilaku pengelolaan keuangan dan kepuasan keuangan. Hipotesis ditolak dimana sikap keuangan tidak mempengaruhi perilaku mengelola keuangan dan kepuasan keuangan. Perilaku mengelola keuangan berpengaruh positif dan signifikan terhadap kepuasan keuangan pada generasi sandwich.

Kata kunci: perilaku mengelola keuangan, kepuasan keuangan, generasi sandwich
Integrated Framework for Constrained Optimization of Horizontal/Deviated Well Placement and Control for Geological CO2 Storage
Authors: Zou Amy , Durlofsky Louis J.
Published: June 2023

A general framework for optimizing the locations and time-varying injection rates of a set of monobore wells for geological carbon storage is presented and applied. Two objective functions, minimization of mobile CO2 fraction at the end of the operation and maximization of storage efficiency, are considered separately in single-objective optimizations and in combination for biobjective optimization. Appropriate linear and nonlinear constraints, involving the geometry of the well configuration, injection rates, and injected mass (for pressure management), are specified. Two derivative-free algorithms, particle swarm optimization (PSO) and differential evolution (DE), are applied and assessed. The various constraints are treated using a preprocessing repair procedure, penalty functions, and a filter method. The framework uses multifidelity (MF) optimization, in which increasing levels of grid resolution are applied during the course of the optimization run. For single-objective optimizations, the MF approach is compared with high-resolution optimization. This treatment is shown to outperform high-resolution PSO and DE optimization in terms of both solution quality and computational requirements. The MF DE optimization case provides the best (feasible) solution, with a 0.090 mobile CO2 fraction at 200 years, which represents a 68% improvement over a heuristic base-case. For the second objective function, MF PSO provides a design that results in a storage efficiency of 0.074, which is about double the base-case value. The well configurations are much different for the two objective functions, with wells more closely spaced, resulting in a single merged plume, for the storage efficiency maximization case. For the mobile CO2 minimization case, by contrast, wells are separated and pulsed, which facilitates dissolution and residual trapping. Biobjective optimization is then performed, again using the MF approach, with a model based on an actual storage operation now under development. The resulting well configurations and CO2 plumes for selected Pareto-optimal solutions are presented.
Calcitriol Alleviates AKI Via Inhibiting Intestinal Inflammation and Restoring Intestinal Microbiota
Authors: Huo Aijing , FengmeiWang
Published: June 2023

Background：The intestinal microbiota affects the inflammatory status of the host and the prognosis of diseases. AKI can lead to microinflammation of intestinal tract and changes of intestinal flora. Calcitriol (Cal) has a protective effect on the intestine.
Methods and Results：In the AKI rat model, intestinal infiltration of inflammatory cells and the deterioration of renal function were significantly alleviated by Cal pretreatment. By increasing the levels of Zonula Occludens-1(ZO-1 and Occludin), Cal significantly prevented the destruction of the intestinal barrier in AKI. In AKI rats, Cal decreased the concentration of Proteobacteria and enhanced the linear discriminant (LDA) score of beneficial bacteria (such as Lactobacillus). Cal increased the expression of butyric acid among intestinal metabolites. Cal supplementation decreased serum LPS levels and downstream HMGB1-MYD88-NF-κB-p65 signaling.
Conclusions：High-dose Cal may play a protective role in AKI by regulating HMGB1-MYD88-NF-κB-p65 signaling pathways and the intestinal microbiota in rats. This study demonstrates the renal effects of Cal. The experiment revealed a close interaction between the kidney and the intestine. It provides new insights for the treatment of AKI.
Brain-derived neurotrophic factor serves as a tumor-trophic factor for lung cancer by controlling cell cycle
Authors: Sheng-Lan Wang , Xiu-Ying He , Li Chen , Yue-Xiang Zheng , Sheng-Lan Liu , Wang Ting-Hua , Yun-Hui Zhang
Published: June 2023

Background
The nervous system plays a key role in the lung development, and its dysfunction might be related to the occurrence of lung cancer. In fact, neurotrophic factors, especially brain-derived neurotrophic factor (BDNF), promote tumor malignancy, in which, however, the mechanism remains to be illustrated.
Methods
Lung cancer cell-A549 cell line was included in the study. HSV-BDNF-ORF/HSV-BDNF-shRNA vectors were prepared and transfected into A549 cells. The proliferation and migration were detected by xCELLigence Real-Time Cell Analyzer. Cell apoptosis was determined through Flow cytometry. The gene expression on transcriptome level was detected by gene microarray analysis. Bioinformatics analysis consisted of GO, KEGG and String analysis.
Results
Firstly, we found that the expression of BDNF in A549 cells was increased. Then we successfully constructed HSV-BDNF-ORF and HSV-BDNF-shRNA vectors, which could lead to the increase or decrease in BDNF expression after transfected into A549 cells, respectively. Moreover, BDNF served as “tumor-trophic factor” that promoted A549 cells proliferation and migration, while BDNF knockdown triggered the cell apoptosis of A549 cells. Mechanistically, BDNF-induced cell proliferation might be linked with the upregulation of cell cycle-related genes. The cell apoptosis triggered by BDNF knockdown should be attributing to the up-regulated apoptosis-associated genes.
Conclusion
BDNF served as a tumor-trophic factor mediating lung cancer cell proliferation and apoptosis by regulating the cell cycle-related and cell apoptosis associated-genes, indicating that BDNF might exert significant impact on treating lung cancer.
Synthesis of a New Biocomposite for Fertiliser Coating: Assessment of Biodegradabilityand Thermal Stability
Authors: Ketabchi Mohammed Reza , Soltani Salman Masoudi , Chan Andy
Published: June 2023

The bio- and thermal degradation as well as the water absorption properties of a novel biocomposite comprising cellulose nanoparticles, natural rubber and polylactic acid have been investigated. The biodegradation process was studied through an assembled condition based on the soil collected from the central Malaysian palm oil forests located in the University of Nottingham Malaysia. The effects of the presence of the cellulose nanoparticles and natural rubber on the biodegradation of polylactic acid were investigated. The biodegradation process was studied via thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). It was understood that the reinforcement of polylactic acid with cellulose nanoparticles and natural rubber increases the thermal stability by ~20 °C. Limited amorphous regions on the surface of the cellulose nanoparticles accelerated the biodegradation and water absorption processes. Based on the obtained results, it is predicted that complete biodegradation of the synthesised biocomposites can take place in 3062 h, highlighting promising agricultural applications for this biocomposite.
Study of road bitumens operational properties modified with phenol-cresol-formaldehyde resin
Authors: Pyshyev Serhiy , Demchuk Yuriy , Gunka Volodymyr , Donchenko Myroslava , Korchak Bohdan , Sidun Iurii , Poliuzhyn Ihor , Drapak Iryna
Published: June 2023

Phenol-cresol-formaldehyde resin (PhCR-F) was obtained using minor liquid products of coal coking by means of a relatively inexpensive method. It is shown that petroleum road bitumens, to which 1.0 wt % PhCR-F is added, in terms of basic physical and mechanical parameters comply the requirements of the regulatory document for bitumens modified with adhesive additives. Research of the operational properties of these modified bitumens as a binding material for asphalt concrete is described. It has been proven that modified bitumen can store stable properties during their application (counteraction to technological aging). The interaction of bitumens modified by PhCR-F with the surfaces of mineral materials, which occurs during the creation of asphalt concrete coatings, was studied. It was shown that the addition of 1.0 wt % PhCR-F to road bitumen significantly improves the adhesion of the binder to the mineral material and increases the hydrophobicity of such a coating.