bluuebunny/crossref_metadata_2025 huggingface dataset:
THE BAJAKAH (SPATHOLOBUS LITTORALIS HASSK.) STEM PLANT EXTRACT EFFECT ON THE BLOOD GLUCOSE OF STREPTOZOTOCIN-INDUCED WISTAR MALE RATS
Authors: Wirjatmadi Bambang , Isaura Emyr Reisha
Published: May 2024

Introduction: Health practitioners have tried to reduce the prevalence of diabetes mellitus, which increases globally every year, but the result has not been optimal yet. Meanwhile, the indigenous people of the Dayak tribe from Borneo Island of Indonesia believe that the Bajakah plant (Spatolobus littoralis Hassk) can treat many diseases, including reducing blood glucose. However, the effect of the Bajakah stem plant extract on blood glucose regulation is still vague. Aims: Therefore, our animal-experimental research aimed to test the effect of the Bajakah stem plant extract using streptozotocin-induced Wistar male rats. Methods: We grouped the rats into K1, K2 (negative and positive control groups, respectively), P1, P2, and P3 (with additional Bajakah stem extract 50, 100, and 150 mg/kg body weight, respectively), with each group consisted of five rats. We collected blood glucose and insulin level at baseline (T1) and end of the intervention (T2). Results: This study found the highest mean ± standard deviation of insulin level was in the C2 group (5.10±0.84 µU/mL) and the lowest value in the X3 group (3.65±0.41 µU/mL). However, we found a significant difference in the blood glucose level at baseline and the end of the intervention (p<0.001). The highest reduction means value on blood glucose level was in the X3 group (T1: 471.40±89.24 mg/dL; T2: 122.80±12.50 mg/dL). Conclusion: The Bajakah stem plant’s extract intervention affects the blood glucose level of Wistar male rats, possibly through the free radical’s protection effect on the target cell receptor that binds to insulin and glucose.
SENSITIVITY AND SPECIFICITY OF A NEW TOOL FOR EARLY DETECTION OF RISK FACTORS FOR NON COMMUNICABLE DISEASES IN URBAN WORKERS
Authors: Erista Nai Hildagardis Meliyani , Wulandari Risky
Published: May 2024

Introduction: Non communicable diseases (NCDs) have an impact on health, economy, and quality of life, and can reduce worker productivity. Approximately 41 million people die from NCDs every year, accounting for 74% of deaths worldwide. The Deteksi Dini Faktor Risiko Gizi dan Kesehatan (DDR-GizKes) is instrument designed for the early detection of nutritional and health risk factors related to NCDs that affect the productivity of urban workers . A screening test is essential part of this newly developed tool. Aims: This study aims to test the sensitivity and specificity of the DDR-GizKes instrument for detecting NCDs in urban workers. Methods: This study used a descriptive observational design with a cross-sectional approach. The population consisted of 227 teachers and staff in high schools in Yogyakarta who were selected using a cluster random sampling technique. Hypertension was used as the gold standard for the screening test. Results: The nutritional risk factor test had a sensitivity of 15.8% and a specificity of 94.2%. The positive predictive value (PPV) for the nutritional risk factor was 16.7% and the negative predictive value (NPV) was 93.8%. Meanwhile,  the health risk factor test had a sensitivity of 15.8% and a specificity of 86.4%. The PPV for the health risk factor was 7.89% and the NPV was 93.3%. Conclusion: The DDR-GizKes instrument had low sensitivity but high specificity. Further research is necessary to establish the scoring system of the DDR-GizKes instrument in populations with a high prevalence of NCDs using a larger sample size.
Characteristics of Neuropsychiatric Systemic Lupus Erythematous in Dr. Sardjito General Hospital
Authors: Tri Wirasto Ronny , Winengku Basuki Adi
Published: May 2024

Introductions: Systemic lupus erythematosus (SLE) is one of the diseases that affects the system organs. Neuropsychiatric SLE (NPSLE) refers to the display of SLE involving both neurologic and psychiatric conditions. Methods: This retrospective study used inpatient and outpatient data from patients diagnosed with unspecified SLE and also included psychiatric manifestations between 2017 and 2021. Results: The patients' age range was from under 10 to over 70 years old, and the average age was 31.49 years old. The highest percentage was between 31 and 40 years old, which was 27%. Out of 100 patients, 61 received the majority of their care from the internist. The highest percentage of psychiatric disorders was unspecified depressive disorder, with 17%. The second-largest proportion was other specified neurotic disorders, which was 11%. Additionally, 10% of the patients experienced a mild cognitive illness. Based on gender, women had a higher proportion compared to men. Conclusions: Our study showed that there were 100 NPSLE cases over five years, and the highest percentages were depressive disorder, neurotic symptoms, and mild cognitive disorder.
ЕКОЛОГІЧНІ АСПЕКТИ ПРИПИНЕННЯ ДІЯЛЬНОСТІ КАР’ЄРІВ
Authors: ХОХОТВА Олександр , КОВАЛЬОВА Олена
Published: May 2024

У роботі показані основні екологічні наслідки гірничо-добувної діяльності у вигляді порушених земель, забруднення поверхневих і підземних вод, викидів забруднюючих речовин у довкілля, порушення локальних екосистем, утворення відходів добувної діяльності. Всесвітній саміт зі сталого розвитку, започаткований Організацією Об’єднаних Націй, визнав важливість внеску видобування корисних копалин у сталий спосіб, а саме необхідність підтримки зусиль для належного розгляду екологічних, економічних, соціальних наслідків та впливу на здоров’я людини у видобуванні корисних копалин, мінералів і металів, протягом усього їх життєвого циклу. Описано основні напрямки діяльності, на які слід звернути увагу при  інтегрованому закритті кар’єрів і шахт та при плануванні закриття протягом різних етапів життєвого циклу видобувної діяльності проєкту.
КЛАСИФІКАЦІЯ ЛАНДШАФТІВ ДЛЯ УПРАВЛІННЯ ОБ’ЄДНАНИМИ ТЕРИТОРІАЛЬНИМИ ГРОМАДАМИ (НА ПРИКЛАДІ ФАСТІВСЬКОГО РАЙОНУ)
Authors: ДУДАР Тамара , ТІТАРЕНКО Ольга , РАТУШНЮК Леся
Published: May 2024

У даному дослідженні представлено характеристику та класифікацію ландшафтного покриву на прикладі Фастівського району Київської області за допомогою знімків Sentinel-5. Показано, що найбільше поширення мають орні угіддя (45 %), тоді як водні об’єкти займають лише 0,85 % досліджуваної території. Особливо вражає те, що водно-болотні угіддя займають майже 1% всієї території і з часом можуть стати більшими. Це не характерно для досліджуваної території та заслуговує на увагу для майбутнього управління територіями об’єднаних територіальних громад. Цей тип класифікації варто зробити для кожної ОТГ в Україні, оскільки це допоможе в управлінні їх територіями.
The effect of independence and gender of BOD, managerial and institutional ownership, and ownership concentration on tax aggressiveness
Authors: Butar-Butar Dea Tiara Monalisa , Yunita Lidia , Dewi Sari
Published: May 2024

This study examines the relationship between board independence, board gender, management ownership, ownership concentration and institutional ownership with tax aggressiveness in listed companies in Indonesia in the LQ45 reporting sector. Research data processing was executed with E-views 12 software. The source of research data is secondary data using library research methods, namely collecting information from various sources such as journals, theses, previous research, and others, as well as obtaining research sample data through the Indonesia Stock Exchange (IDX) website. The results showed that board independence had a significant positive effect on tax aggresiveness.
Financing education spending in the context of interbudgetary relations in the Republic of Kazakhstan
Authors: Zamirbekkyzy Maslikhat , Saparova Botagoz , Bulakbay Zhanat
Published: May 2024

In the current conditions, education is endowed with strategic importance as a sphere of social activity that directly forms the level of intelligence of the population, ensuring competitiveness and innovation in the development of the country's economy. Therefore, the study’s relevance is because the educational capital obtained in the learning process is a combination of theoretical knowledge, practical skills, work experience, and personal characteristics that bring a person income during his career and stimulate further investment in education. Education impacts each citizen’s income and directly affects the economic development of the country, its financial capabilities, and national competitiveness. Thus, this article aims to reveal the critical aspects of republican and local financing of education in Kazakhstan and the prospects for its development. The methodological basis of the research is formed by a system of general scientific and unique research methods: synthesis, system-analytical analysis, and abstract-logical method. The critical result of the work is the systematization of acquisitions within the framework of the researched topic and the study of the features of optimizing the decentralization of education financing in Kazakhstan. Proposed: to increase the efficient distribution of financial resources at all levels of the budget system; increase the opportunities for educational institutions to raise additional funds through educational innovations, expand the list of paid services provided by such institutions; carry out decentralization of education, taking into account the characteristics of the regions, their production potential, the demographic situation and the interests of territorial communities. The results of this scientific study, as well as the conclusions formulated on their basis, are of significant importance both for the scientific community and for financial experts and practitioners from the educational field since they have a structured presentation of the material based on which logical and constructive conclusions are drawn, which may have an impact on the subsequent processes of reforming the financial provision of education in Kazakhstan.
Ballistic design of spacecraft’s orbits using gravity-assist maneuvers in projects for studying the solar circumpolar regions from positions over ecliptic
Authors: Tsaregorodtsev Andrey Yurievich
Published: May 2024

Conducting space scientific experiments to study the circumpolar regions of the Sun is impossible without ballistic design of orbits with a high inclination to the plane of the solar equator. In the domestic Interheliozond project, it is necessary to implement an orbital inclination of at least 30 degrees. Direct maneuvering of the spacecraft in order to increase the inclination to the plane of the solar equator requires high costs of characteristic speed. Minimizing the costs of constructing orbits with a high inclination can only be achieved using chains of gravity assist maneuvers for the planets of the Solar System, the methods and algorithms for constructing which are considered in this paper.
Psychological Responses and Coping Mechanisms of Gay Men in Adapting HIV/AIDS: A Qualitative Study
Authors: Silalahi Malianti , Fitriani Nurlaila
Published: May 2024

Aims: This study explores the psychological responses and coping mechanisms employed by gay men in adapting to HIV/AIDS.
Methods: This research is qualitative research with descriptive methods. The sample was taken using a purposive sampling technique with inclusion criteria, namely: gays who were declared positive for HIV/AIDS as proven by a doctor's statement stating that they were positive for COVID-19, were undergoing medical treatment both inpatient and outpatient, had experience interacting with nurses when undergoing treatment. This study involved four key informants to recruit potential participants who meet the inclusion criteria. Data analysis involved thematic analysis.
Results: 14 participants were included. Four themes emerged: (1) anxiety and stress arising from interpersonal conflicts post-diagnosis, (2) diverse stages of the grieving process, (3) feelings of helplessness confronting the reality of HIV/AIDS, and (4) utilization of problem-solving coping mechanisms as a means of acceptance.
Conclusion: The study emphasizes the importance of empowering gay men with HIV/AIDS by facilitating access to healthcare and social support. Empowerment enhances their ability to leverage internal resources to manage the disease, ultimately aiding them in leading more fulfilling lives.
APPLICATION OF FUZZY VECTOR OPTIMIZATION METHODS FOR DIET COMPILATION
Authors: Matviienko Olha Ivanivna , Miroshnichenko Oleksandr Okeksandrovich
Published: May 2024

The purpose of this work is to study an approach to solving the problem of fuzzy vector optimization for compiling a diet. It is necessary to develop a daily ration that provides human needs in nutrients and energy and is the best in terms of costs and weight. For this purpose the problem of choosing the best alternative from a given fuzzy set of alternatives is solved, while the quality of the alternative is evaluated using several partial efficiency cri- teria. The goal in the task is fuzzily defined. According to the Zadeh – Bellman idea, a fuzzy solution to a problem is the intersection of a fuzzy goal and a fuzzy set of alternatives. The paper considers the problem of fuzzy two-criteria optimization. Partial criteria that are minimized are the weight and cost of the daily ration. Fuzzy needs for nutrients and kilocalories are determined by fuzzy triangular numbers. For an approximate solution of the problem, an algorithm is proposed according to which a sequence of linear programming problems is solved. The computer program was created that implements the solution of this problem in the Wolfram Matematica package. The following results were obtained: a set of products, their weight and cost were determined for the daily diet. The degree of confidence that the found plan is optimal is determined. On the basis of the proposed mathe- matical model and the method of its solution, a software application allowing to choose food products, enter the necessary restrictions in a user- friendly form, and receive one or more options for the daily ration at the output was created. Such an application will be useful for nutritionists, ath- letes, doctors and other people who are concerned with the problems of healthy eating.
OPTIMIZATION OF CORPORATE STRATEGY: ELIMINATION OF INEFFECTIVE ECONOMIC COMPONENTS
Authors: Suslikov Stanislav
Published: May 2024

This article addresses the crucial issue of optimizing corporate strategies in the context of modern economic instability. The authors explore information processing methodologies necessary for identifying and eliminating ineffective economic components in the strategic planning of a company. The article examines the results of analyzing the experiences of both domestic and international companies in the field of corporate strategy optimization. The main emphasis is placed on the utilization of contemporary methods and tools for information processing, such as semantic analysis, comparative analysis, juxtaposition, and others, to obtain objective data and numerical assessments. The authors highlight key factors that should be considered when optimizing a corporate strategy, including efficiency, profitability, risks, competitiveness, and others. They also discuss approaches to selecting sources of information and data processing methods. The article provides practical recommendations for company executives to improve the strategic decision-making processes, enhance the overall socio-economic state, and increase the competitiveness of the enterprise in the conditions of economic instability.
Consistent Factors Influence Body Mass Index Thresholds for Total Joint Arthroplasty Across Health-Care Systems
Authors: Godziuk Kristine , Fast Andrew , Righolt Christiaan H. , Giori Nicholas J. , Harris Alex H.S. , Bohm Eric R.
Published: May 2024

Background:

Body mass index (BMI) thresholds are used as eligibility criteria to reduce complication risk in total joint arthroplasty (TJA). This approach oversimplifies preoperative risk assessment and inadvertently restricts access to effective surgical treatment for osteoarthritis. A prior survey of orthopaedic surgeons in the United States identified complex underlying factors that influence BMI considerations. To understand whether similar factors exist and influence surgeons in a different health-care system setting, we investigated Canadian surgeons’ views and use of BMI criterion thresholds for TJA access.

Methods:

A cross-sectional online qualitative survey was conducted with orthopaedic surgeons performing TJA in the Canadian health-care system. Responses were anonymous and questions were open-ended to allow for candid perspectives. Survey data were coded and a systematic process was followed to identify major themes. Findings were compared with U.S. surgeon perspectives.

Results:

Sixty-nine respondents had a mean age of 49.0 ± 11.4 years (range, 33 to 79 years), with a mean surgical experience duration of 15.7 ± 11.4 years (range, 2 to 50 years). Surgeons reported variable use of BMI thresholds in practice. Twelve interconnected factors that influence BMI considerations were identified: (1) variable evidence interpretation, (2) surgical challenge, (3) surgeon beliefs and biases, (4) hospital differences, (5) access to resources, (6) health system bias, (7) patient health status, (8) patient body fat distribution, (9) patient decisional burden (to lose weight or accept risk), (10) evidence gaps and uncertainties, (11) need for innovation, and (12) societal views. Nine themes matched with findings from U.S. surgeons.

Conclusions:

Parallel to the United States, complex, interconnected factors influence Canadian orthopaedic surgeons’ variable use of BMI restrictions for TJA eligibility. Despite different health-care systems and reimbursement models, similar technical and personal factors were identified. With TJA practice guidelines advising against hard BMI criteria, attention regarding access to resources, surgical training, and innovations to address TJA complexity in patients with large bodies are critically needed. Future advancements in this sphere must balance barrier removal with risk reduction to ensure safe and equitable surgical care.

Clinical Relevance:

This study may influence surgeon behaviors with regard to hard BMI cutoffs for TJA and encourage critical thought about factors that influence decisions about surgical eligibility for patients with high BMI.
Personal Storyworlds
Authors: Hansen Kai Arne
Published: May 2024

By combining perspectives from transmedial narratology and musicology, this article explores how the notion of a “personal storyworld” can offer new opportunities for understanding the transmedial processes whereby pop artists’ personas are continually (re-)constructed and (re-)negotiated through and across myriad points of contact between artists and audiences. Emphasis is placed on the performative potential of audiovisual aesthetics and public posturing, on the one hand, and on audiences’ interpretive flexibility, on the other. These related themes are addressed through a case study of an artist who aptly exemplifies the continual transfiguration of pop personas, namely Justin Bieber. The main part of the case study concerns how Bieber’s sixth studio album, Justice (2021), and associated material (music videos, live performances, interviews, promotional material, social media posts) related to and formed part of his broader personal storyworld. This sets up an exploration of how the dynamics between retrospection and reinvention shape the reframing of personas, which raises a series of questions concerning the dialectic between continuity and change, artist-audience dynamics, and transmedial processes of interpretation.
Morphological transition after medical treatment of emphysematous pyelonephritis over time
Authors: Yamamoto Ukyo , Yagame Motoka , Uchida Daisuke , Hara Masumi , Takeuchi Hideyuki , Kawarazaki Hiroo
Published: May 2024

Background Emphysematous pyelonephritis (EPN) is a necrotizing infection characterized by the production of gas in the renal parenchyma, collecting　system or perirenal tissue. The treatment strategy, especially for surgical intervention, in EPN has been based on the Huang and Wan classifications. Huang's classification is based on the extent of gas and abscess spillover, while Wan's classification is based on the morphology of gas and fluid retention. Wan's classification type I EPN is considered more severe compared to type II EPN and pathophisyological mechanisms are speculated as the cause of the different presentation but the actual cause is unknown. In the present case, conservative treatment of EPN in the early stages of the disease allowed us to show that Wan's classification may represent a time series of morphologic changes throughout EPN.
Case presentation A 72-year-old woman treated for diabetes was admitted because of suspected treatment-resistant pyelonephritis. Her CT scan at presentation was suggestive of EPN and antibiotics was started. After additional medical treatment, a follow-up of CT image showed that the initial appearance of bubbly gas formation changed into a fluid-forming abscess. This transition shows that type I is an early phase image of EPN and type II image is seen following the early phase. Thereafter no change was seen in CT image and residing inflammation led to planned nephrectomy on day 35. Antibiotics were discontinued and no recurrence was confirmed.
Conclusions Wan’s type I and II EPN has been often reported as different pathophysiological entities. Our case shows that these two subtypes may represent stages in the progression of EPN. Medical treatment for type I may permit safe nephrectomy for type II EPN.
Association between the Composite Dietary Antioxidant Index and Nonalcoholic Fatty Liver Disease: Evidence from National Health and Nutrition Examination Survey 2005-2016
Authors: Fu Yidian , Jiang Chao , Li Zonglin , Zhang Jingbo , Lv Peiyuan
Published: May 2024

Importance: Oxidative stress is an important contributor to the progression of nonalcoholic fatty liver disease (NAFLD), however, the relationship between Composite Dietary Antioxidant Index (CDAI) and NAFLD in US adult population remains unclear.
Objective: To access whether CDAI is associated with NAFLD in US adults.
Design, setting, and participants: This population-based cross-sectional study used data on US adults from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 cycles. Data were analyzed from January to February 2024.
Exposures: CDAI obtained from the dietary intake questionnaire.
Main outcomes and measures: The main outcome was NAFLD which defined by the US fatty liver score (USFLI) ≥ 30. Sampling weights were calculated according to NHANES guidelines.
Results: Among 9746 adults included in this study (mean age, 48.3 years; 4662 [47.6%] males), 3324 (33.0%) were classified as having NAFLD using USFLI. In the fully adjusted of multivariable logistic regression, CDAI was negative associated with NAFLD (odds ratio [OR], 0.95; 95% CI, 0.93-0.98). Furthermore, the highest quartile CDAI were 34% less likely to have NAFLD than those with the lowest quartile (OR, 0.66; 95% CI, 0.52-0.85). In subgroup analyses, CDAI was associated with NAFLD among participants who were male (OR, 0.94; 95% CI, 0.92-0.97), without diabetes (OR, 0.95; 95% CI, 0.93-0.97), and without metabolic syndrome (OR, 0.93; 95% CI, 0.91-0.96). In addition, the negative correlation between CDAI and NAFLD was robust in sensitivity analyses that excluded potential hepatotoxic medication use (OR, 0.95; 95% CI, 0.93-0.98), or non-Hispanic Black participants (OR, 0.95; 95% CI, 0.93-0.98), defined NAFLD based on the hepatic steatosis index score (HSI) (OR, 0.97; 95% CI, 0.95-0.99), and used unweighted logistic analysis (OR, 0.96; 95% CI, 0.94-0.98).
Conclusions and relevance: In this cross-sectional study based on six cycles (2005-2016) of the NHANES, CDAI was negative associated with NAFLD in US adult population. This association may provide a new approach to explore the factors affecting dietary interventions to reduce the incidence of NAFLD.
Bio-Thermal Non-Equilibrium Dynamics and Thermal Damage in Biological Tissues Induced by Multiple Pulse-Lasers Irradiations
Authors: Jawo Edrisa , Hassan Mohsan
Published: May 2024

Background: Laser therapy offers precise medical treatment by directing focused light beams to specific areas without harming surrounding tissue. This precision is particularly valuable in tissue treatment, including cancer therapy, where minimizing collateral damage is critical. The current study focuses on bio-thermal dynamics and thermal damage in biological tissues induced by multiple pulse-laser irradiations.
Model: To examine the thermal behavior, the Local Thermal Non-Equilibrium (LTNE) bioheat Transfer model with porosity and dual lag effects is developed. The model contains partial differential equations and is solved by numerical method.
Results: Obtained results demonstrate temperature variations and thermal damage in tissues, influenced by factors like laser intensity, incident duration, and tissue porosity. Higher intensity of laser and longer laser durations increase the temperature distribution and thermal damage as well. Porosity inversely affects temperature distribution, with higher porosity leading to decreased distribution.
Novelty: This study introduces the application of multi-time lasers, a novel approach that has not been previously explored in the literature. By investigating the impact of laser parameters and tissue characteristics, it enhances understanding and guides the development of effective laser therapies for medical applications.
Cardiovascular risk associated with BMI and metabolic health phenotypes based on measures of coagulation factors.
Authors: Basurto Lourdes , Valle María , Robledo Ariadna , O'Leary Sean , REYES-MALDONADO ELBA , Gaspar Jennyfer , Rosales Erika , Vega-Garcia Sara , Martínez-Murillo Carlos
Published: May 2024

Introduction: While the classification of metabolically healthy individuals with obesity remains uncertain, recent research links central obesity to thromboembolism and cardiovascular disease, potentially indicating a hypercoagulable state in some individuals with obesity. This study investigates coagulation and inflammation differences between obesity and normal-weight phenotypes.
Methods: 225 adult women, participants were subjected to clinical examinations, and biochemical assessments. These assessments classified participants into four distinct phenotypes, namely MHNW (Metabolically Healthy Normal Weight), MUNW (Metabolically Unhealthy Normal Weight), MHO (Metabolically Healthy Obesity), and MUO (Metabolically Unhealthy Obesity), based on a combination of BMI and metabolic criteria. Subsequently hemostatic proteins and interleukin levels were compared.
Results: Among 225 female patients, the MHO group was younger, with higher measurements like visceral fat and BMI, while MUO had the highest values in HOMA-IR, triglycerides and LDL-c. Coagulation proteins showed normal levels. However, MHNW had significantly lower FV, and groups without obesity (MHNW and MUNW) had lower FVIII and FIX. FXII in MHNW did not significantly differ. Inflammatory markers revealed IL-6 negatively correlated with PC and AT but positively with FVIII and FIX. IL-10 negatively correlated with FII, FV, FVII, FXI, and FXII, while TNF-α and IL-1 positively correlated with FVIII and FIX.
Conclusion: This study challenges the MHNW metric, revealing metabolic marker elevations in non-obese groups. Additionally, MHO individuals exhibited pro-coagulant protein increases compared to MUO, suggesting limited clinical utility in categorizing the broader population with obesity. The interplay between metabolic health and body size phenotypes challenges traditional approaches to predicting health risks.
Analysis of College Students' physical fitness test results considering process evaluation in Physical Education Teaching
Authors: Miao Ning , Chang Shuhua , Cheng Yulan , Wang Xinyu , wang xinran
Published: May 2024

With the development of the times, college students with a relatively loose living environment are facing a variety of temptations. College students often ignore the importance of physical exercise because of sedentary use of intelligent devices or some bad living habits, so that their physical quality decreases and can not meet the basic requirements of school physical fitness test. This trend has attracted the attention of all sectors of society, Many scholars have also conducted preliminary research on this phenomenon. Therefore, this paper establishes a dynamic game model from the perspective of economics, compares and analyzes any two students as the two sides of the game, and obtains the students' attitude towards physical testing by using two evaluation methods: process evaluation and final evaluation, Class sports atmosphere and the price paid for the physical test are the three control variables to optimize the physical test results. Through the reward and punishment scheme proposed by the process evaluation, students are encouraged to continuously strengthen physical exercise. When students have rich interest in sports, students will regard sports as a living habit, so as to effectively improve students' physical quality.
METTL3 drives heart failure by regulating Spp1 and Fos m6A modification in myocardial infarction
Authors: Cheng Hao , Li Linnan , Zhou Yufei , Ma Jiaqi , Xu Rende , Xue Junqiang , Chen Lu , Song Xiaoyue , Shi Yuekai , Zou Yunzeng , Ma Jianying , Ge Junbo
Published: May 2024

While m6A modification has been reported in myocardial infarction (MI), the detailed mechanism by which METTL3 regulates the progression of the disease has not yet been elucidated, and it remains unclear why m6A modification increases after MI. Through MeRIP-seq and extensive bioinformatics analysis, the target genes SPP1 and FOS with the most significant m6A modification and differential expression in MI were screened. We successfully constructed heart specific Mettl3 knockout mice (Mettl3CKO) to verify that METTL3 promotes the deterioration of cardiac function after MI. We performed complementary molecular methods to assess protein quantity and interactions to identify mechanisms regulating this response. We manipulated select molecular pathways using both genetic and pharmacological methods to validate these mechanisms. Here, we showed that METTL3 exerted methyltransferase activity-dependent functions in gene regulation in MI, and a significant transcription factor HuR assisted the function of METTL3. and demonstrated that METTL3 was critical for the promotion of heart failure after MI. More specifically, METTL3 directly interacted with HuR through its nuclear localization domain in the cell nucleus under normoxia condition. When hypoxia developed, METTL3 separated from HuR and deposited m6A into 5’UTR of Spp1 and Fos mRNA to maintain their stability. In contrast, HuR bound to the ARE domain of 3’UTR of Spp1 and Fos mRNA to take them to the cytosol, maintaining their stability. Moreover, HIF-1α directly interacted with the HRE domain of Mettl3 to promote its transcription, and HuR bound to the ARE domain of 3’UTR of Mettl3 mRNA to maintain its stability to promote following translation. Collectively, our studies revealed previously unappreciated functions of METTL3 with the help of HuR, and a direct target of HIF-1α under normoxia condition, which together contribute to its essential function in MI, suggesting therapeutic potential for targeting the METTL3/HuR/Spp1(Fos) mRNA axis.
AAPS: Secure Cross-chain Scheme Based on Anti-attack Protocol Slot
Authors: Mao Hanyu , Nie Tiezheng , Yu Ge
Published: May 2024

With the increasing development of blockchain technology, numerous blockchain structures and tokens have been created. However, due to the independent nature of these chains, the concept of "cross-chain" was introduced to enable interoperability between them. Unfortunately, the development of cross-chain technology has resulted in numerous technical vulnerabilities, leading to significant losses of assets and disclosure of private data. Additionally, mainstream cross-chain schemes such as relay chain and security committee have become increasingly centralized, resulting in significant risks and the potential for collusion attacks. Therefore, in this paper, we propose the Anti-Attack Protocol Slot (AAPS) scheme to ensure the security of cross-chain interactions. This scheme is designed to resist multiple types of network attacks without requiring additional third-party centralized nodes or security boards. Through experiments, we demonstrate the reliability of AAPS. In summary, this paper proposes a novel approach for enhancing the security of cross-chain interactions, thereby addressing the technical vulnerabilities associated with current cross-chain schemes. The AAPS scheme provides a decentralized solution that can effectively protect against various network attacks.
Unveiling the Multi-dimensional Risks of Returning to Poverty: Insights from the Transformation of China's Poverty Alleviation Policies
Authors: Fan Cong , Chen Renxing , Mao Qingduo
Published: May 2024

The eradication of absolute poverty in China by 2020 marked a significant milestone, yet ensuring sustained prosperity remains a critical challenge in the country’s rural revitalization agenda (2021–2050). This study indicates that individuals escaping poverty confront multifaceted risks of returning, shedding light on the unintended consequences of policy transformation in poverty alleviation. County G in Y Province, chosen for its representativeness and diversity of challenges, served as the study site. Inductive content analysis, involving 25 participants through in-depth interviews, was utilized for data analysis. A semi-structured interview guide, unanimously agreed upon by researchers, facilitated discussions on the risks of returning to poverty before and after the implementation of poverty alleviation policies. This study identifies and categorizes multi-dimensional risks linked to poverty-returning, encompassing general risks predating poverty alleviation initiatives and policy-induced risks from shifts in poverty alleviation measures.Findings deepen our understanding of these risks, highlighting general risks such as natural disasters, resource scarcity, and limited social support, as well as the policy-induced risks due to shifts in strategies that have led to decreased support for rural areas. The research underscores the inherent instability of policy transitions in anti-poverty efforts and calls for policymakers to address this vulnerability by crafting more sustainable poverty reduction strategies.
Efficient production of 6-Hydroxynicotinic Acid by newly isolated Pseudomonas poae
Authors: Li Hua , Tang Jiacheng , Li Yi , Cao Xunliang , Liu Tang , Xin Kaixiang , Xu Yinbiao , Zhou Pei , Sun Yang , liu yupeng
Published: May 2024

Nicotinic acid dehydrogenase possesses the capability to convert nicotinic acid into 6-hydroxynicotinic acid, a compound of significant research value as a pharmaceutical intermediate. The extraction of nicotinic acid dehydrogenase is primarily performed by strains. However, the enzyme activity of the strains reported currently is relatively low, and their potential to catalyze the production of 6-hydroxynicotinic acid is insufficient to meet industrial requirements. Due to the revealing properties of 6-hydroxynicotinic acid, this study proposes a technique for calculating the luminescence intensity of colonies, which is based on a fluorescence spectrometer. The developed method establishes a reliable linear relationship (88.2%) between the luminescence intensity and enzyme activity. Consequently, it has been employed to screen strains that produce nicotinate dehydrogenase. This screening approach allows for the evaluation of about 500 enzyme-producing strains daily, presenting an efficient strategy for screening. Through this approach, a novel high enzyme activity strain producing nicotinic acid dehydrogenase, Pseudomonas poae have been obtained, which designated as HD530. After process optimization, it was utilized to produce 6-hydroxynicotinic acid, achieving a high yield of 155.45 g/L within 72 hours, meeting the requirements for industrial production. The effectiveness and potential of this technique lie in its application for strain screening and improvement.
Landslide Disaster Modeling and Analysis using CDEM in the Southern Slope of Fushun West Open Pit Mine
Authors: Xie Jiang , Wang Leiming , Yang Jingyu , Zhang Hui , Lu Yong , Hu Wen
Published: May 2024

Landslides in open-pit mines have extremely high potential risks in the mining process due to their characteristics such as high speed, short distance, and the chain effect of other disasters. Taking the southern slope landslide of Fushun West Open Pit Mine (FWOPM) as an example, based on the dynamic process of the southern slope landslide, the deformation and failure mechanism and disaster chain disaster mode of the southern slope landslide are analyzed. The continuum discontinuum element method (CDEM) is constructed to reveal the evolution characteristics of the landslide, and a sudden change series method is proposed for landslide disaster analysis. The research results indicate that the entire process of the southern slope landslide can be summarized as follows: bedding slip stage, slight bending stage, strong bending stage, uplift stage and cut through stage. The geological hazard level of the southern slope landslide in FWOPM has a membership degree of 0.97, which belongs to a super large landslide and is basically consistent with the actual situation. This method is effective in the analysis of landslide disasters in southern slope landslide, and has good significance for slope landslide disasters prediction in FWOPM.
Enhanced Neural Recovery and Reduction of Secondary Damage in Spinal Cord Injury through Modulation of Oxidative Stress and Neural Response
Authors: Zhu Jiwen , Liu Zhenyu , Liu Qi , Xu Qinghua , Ding Chengbiao , Chen Zhu , Li Jun , Wu Zhengwei
Published: May 2024

Spinal cord injury (SCI) presents a critical medical challenge, marked by substantial neural damage and persistent functional deficits. This study investigates the therapeutic potential of cold atmospheric plasma (CAP) for SCI, utilizing a tailored dielectric barrier discharge (DBD) device to conduct comprehensive in vivo and in vitro analyses. The findings show that CAP treatment significantly improves functional recovery after SCI, reduces neuronal apoptosis, lowers inflammation, and increases axonal regeneration. These findings illustrate the efficacy of CAP in fostering a conducive environment for recovery by modulating inflammatory responses, enhancing neuronal survival, and encouraging regenerative processes. The underlying mechanism involves CAP's reduction of reactive oxygen species (ROS) levels, followed by the activation of antioxidant enzymes. These findings position CAP as a pioneering approach for spinal cord injury (SCI) treatment, presenting opportunities for improved neural recovery and establishing a new paradigm in SCI therapy.
Novel 2-Substituted Benzothiazole Derivatives: Synthesis, In-vitro and In- silico Evaluations as Potential Anticancer Agents
Authors: Azzam Rasha A. , Seif Mona M. , El-Demellawy Maha A. , Elgemeie Galal H.
Published: May 2024

Cancer remains a global health concern, demanding the development of new therapeutic medicines. This research focuses on the synthesis, in vitro evaluation, and in silico analysis of new 2-substituted benzothiazole derivatives as possible anticancer drugs. Hybrid molecules comprising benzothiazole and pyridinone rings 10a-d and 14a-d were also synthesized. Several compounds were produced and characterized, using NMR, IR and elemental analysis, with promising anticancer activity against lung H1299, liver Hepg2 and breast MCF7 cancer cell lines. Structure-activity connection investigations identified crucial structural characteristics that influence potency, with particular benzylidine derivatives 7a-g demonstrating higher activity. In-silico ADME research revealed favorable drug-like features for chosen compounds, such as high gastrointestinal absorption and selective CYP inhibition. Toxicological projections indicated few side effects, confirming their potential as medication candidates. Docking studies revealed their binding mechanisms and interactions with protein tyrosine kinases PTK, identifying intriguing candidates for further study.
A Rapid Urine Sensor for Detection of Sports Anaemia in Ultra-Endurance Athletes
Authors: Griffiths Owen , Spivey Alan Christopher , Quinlan Gregory , Cass Anthony Edward George
Published: May 2024

Background
Sports anaemia is a condition associated with high levels of haemolysis after intensive exercise such as ultra-endurance rowing competitions. Studies have shown that large or continuous muscle contractions can increase the fragility of red blood cells (RBCs), which can lead to intracapillary mechanical haemolysis. Toxicity from haemolysis is caused by the release of cell free haemoglobin (cfHb), haem, and iron from the lysed RBCs. Early detection of sports anaemia can prevent toxicity by facilitating earlier intervention of preventative treatments. However, there are currently no rapid, low-cost, and easy-to-use sensors to detect sports anaemia.
Results
An electrochemical sensor was developed to detect cfHb in urine which is a good biomarker for haemolysis. The chronoamperometric response was characterised and calibrated with Hb spiked urine before evaluating with four ultra-endurance rowers (The Enginoars) during a 37-day cross-Atlantic rowing expedition—the Talisker Whiskey Atlantic Challenge. The limit-of-detection (LoD) of the sensor was determined as 2.2 µM and the 5 µM recovery was 110%. The intercept was − 0.28 ± 0.1 µA and the slope was − 0.18 ± 0.02 µA µM− 1. The mean cfHb concentration of the four rowers was 2.40 µM, 1.56 µM, 2.29 µM, and 3.69 µM. The max cfHb concentration of the four rowers was 11.94 µM, 3.77 µM, 16.73 µM, and 11.91 µM.
Conclusions
The study demonstrated the efficacy of using cfHb in urine as a biomarker for intracapillary haemolysis and sports anaemia. It also provided proof-of-principal for the sensor in ultra-endurance competitions. It showed that while there were several haemolysis spikes during the competition, cfHb levels returned to normal within 1 to 2 days.
Cluster formation in device-to-device (D2D) communications to ensure quality of service & minimize cluster head power consumptions
Authors: Ezeh Ikechukwu Harrison , Ezenugu Isaac A. , Okorogu Victor N. , Ewunonu Tochi C.
Published: May 2024

The research proposed a clustering formation approach that ensures that the chosen cluster head (CH) in D2D communication consumes minimal energy and that the cluster members (CMs) are offered good quality of service. In addition, the study investigated various factors influencing power consumptions of User Equipment (UE) in Device to Device (D2D) Communication. Network and geographic data of the UE were collected within 200m diameter (100m radius) around the chosen base station (BS). A term Hardware Sensing Factor (a weighting factor) was formulated from the collected network data. The HSF and the distance between the UE and the base station were utilized as input data to Self Organizing Map (SOM), an unsupervised machine learning algorithm, to form clusters of the UE. A UE with highest value of HSF and minimal distance to the BS is chosen as the Cluster Head (CH) for each cluster. It was shown that the power consumption of the UE increases as the signal attenuation (which depends on distance) increases. In addition, for every transmission/reception between the Cluster Member (CM) and the BS through the CH, the CH consumes about 2.5% more than the CM. Also, in addition to the effects of signal attenuation, the power consumption of the CH is largely dependent on the number of CMs associated with the CH. Furthermore, it is more energy efficient for the CMs to communicate with the CH than communicate with the BS, especially for edge cell UE.
A novel porous amino-functionalized cellulose composite for highly efficient adsorption of anionic pollutant in water: behavior and mechanism
Authors: Sun Zhong , Deng Chao , Li Yanxin , Yin Yihan , Zhou Wenlong , Duan Xixin , Xu XIaohui , Yang Wei
Published: May 2024

A large amount of domestic and industrial wastewater can pose a great threat to our environment. Thus, searching effective and eco-friendly ways for adsorbing and removing toxic substances (Cr6+, Mn7+, and methyl orange (MO)) in wastewater is urgent and highly desirable. An efficient, mesoporous, and amino-functionalized polydivinylbenzene (PDVB)-cellulose nanocrystal (CNC/PDVB-NH2) with high stability and super-hydrophobicity was developed by crosslinking in this study. The pseudo-second-order model and Langmuir model expressed the adsorption kinetics and isotherm well, indicating the adsorption of Cr6+ and Mn7+ ions on CNC/PDVB-NH2 was monolayer chemisorption. The maximum adsorption amount (qm) of Cr6+ and Mn7+ ions on CNC/PDVB-NH2 was 130.39 mg/g and 308.94 mg/g, respectively. For negatively charged dye methyl orange (MO) also maintain adsorption effect. These results indicated the CNC/PDVB-NH2 can be used as an efficient and reliable absorbent for wastewater treatment, which was worthy of promotion for large-scale application.
Premature aging effects on COVID-19 pathogenesis: new insights from mouse models
Authors: Haoyu Wu , Meiqin Liu , Jiaoyang Sun , Guangliang Hong , Haofeng Lin , Pan Chen , Xiongzhi Quan , Kaixin Wu , Mingli Hu , Xuejie Yang , Lämmermann Ingo , Grillari Johannes , Zhengli Shi , Jiekai Chen , Guangming Wu
Published: May 2024

Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality. Yet, the biological relationship between aging, aging-related comorbidities, and COVID-19 remains incompletely understood. This study aimed to elucidate the age-related COVID19 pathogenesis using a Hutchinson-Gilford progeria syndrome (HGPS) mouse model with humanized ACE2 receptors. Pathological features were compared between young, aged, and HGPS hACE2 mice following SARS-CoV-2 challenge. We demonstrated that young mice display robust interferon response and antiviral activity, whereas this response is attenuated in aged mice. Viral infection in aged mice results in severe respiratory tract bleeding, likely contributing a higher mortality rate. In contrast, HGPS hACE2 mice exhibit milder disease manifestations characterized by minor immune cell infiltration and dysregulation of multiple metabolic processes. Comprehensive transcriptome analysis revealed both shared and unique gene expression dynamics among different mouse groups. Collectively, our studies evaluated the impact of SARS-CoV-2 infection on progeroid syndromes using a HGPS hACE2 mouse model, which holds promise as a useful tool for investigating COVID-19 pathogenesis in individuals with premature aging.