bluuebunny/crossref_metadata_2025 huggingface dataset:
Motion-Corrected Multiphase Imaging with Steady-state Free Precession for Free-breathing 3D Coronary Angiography
Authors: Jang Kwang Eun , Nishimura Dwight , Vasanawala Shreyas
Published: August 2023

For free-breathing 3D coronary angiography, we consider a new multiphase acquisition that consists of a series of short imaging blocks to reduce motion blur in the acquisition window. However, this approach poses two challenges: (1) because the alterations of readout gradient waveforms become large due to the shortened imaging window, eddy current artifacts appear in steady-state free precession imaging, and (2) motion among cardiac phases needs to be addressed. In this work, we propose a new ordering scheme to establish smooth transitions between conic interleaves. Phase-to-phase motion is estimated using self image-based navigators and corrected by motion-based reconstruction.
Highly Accelerated Myocardial Perfusion Using Physics-guided Deep Learning With Structure-encoded Coil Maps
Authors: Demirel Omer , Yaman Burhaneddin , Moeller Steen , Weingärtner Sebastian , Akçakaya Mehmet
Published: August 2023

Myocardial perfusion cardiac MRI is widely used to functionally assess coronary artery disease. Although numerous acceleration techniques are used, improved spatio-temporal resolutions and coverage are desirable. Deep learning (DL) reconstruction has shown improvement over conventional reconstruction techniques at higher accelerations. Yet, SNR/contrast changes across perfusion dynamics hinder their generalization performance. In this work, we propose a multi-coil encoding operator that uses coil maps encoding structural information for physics-guided DL. This provides a uniform contrast at the network output across dynamics, leading to improved image quality compared to physics-guided DL with ESPIRiT coil maps, as well as conventional acceleration methods.
Hypertension is Associated with Intracranial Atherosclerotic Plaque Burden and Distribution: a MR Vessel Wall Imaging Study
Authors: Xiao Jiayu , Song Jae , Cen Steven , Wu Fang , Liu Xiao , Jiang Tao , Schlick Konrad , Li Debiao , Song Shlee , Yang Qi , Fan Zhaoyang
Published: August 2023

Hypertension is one of the most important modifiable risk factor for atherosclerosis. However, the association between blood pressure and intracranial plaque remains unclear. In this study, we investigated the impact of hypertension on intracranial plaque burden and distribution in 174 patients with recent ischemic stroke. Systolic blood pressure and diastolic blood pressure were independently associated with a higher total plaue burden as well as higher plaque counts at the proximal and junctional locations. These findings suggest hypertension may influence not only the count burden but also the distribution of intracranial plaque development.
Detecting Residual Iron Contrast after Ferumoxytol Infusion in Cerebral Vasculature Using High-Resolution SWI at 7T
Authors: Jiang Li , Chen Yongsheng , Muccio Marco , Li Chenyang , Buch Sagar , Haacke E Mark , Ge Yulin
Published: August 2023

Ultra-small superparamagnetic iron oxides (USPIO) enhanced MRI has shown its great potential in detecting vascular abnormality in the brain on T2*-weighted sequences for better showing both macro- and micro-vasculature. In this study, we investigated the quantitative phase changes after Ferumoxytol infusion and examined its residual contrast in brain vasculature at 3-, 7- and 14-day follow-up SWI scans. To quantitatively measure the Ferumoxytol-induced susceptibility, the veins parallel to the main field were chosen for measurement. After measuring the intensity on high-pass filter phase images, the paired t-test showed a significant difference between pre-contrast and post-3d values from the follow-up visits.
Vessel Wall Imaging-Dedicated Automatic Processing Pipeline (VWI-APP): Towards Efficient and Reliable Intracranial Plaque Quantification
Authors: Zhou Hanyue , Xiao Jiayu , Ruan Dan , Fan Zhaoyang
Published: August 2023

We propose an automatic pipeline for atherosclerosis plaque analysis based on magnetic resonance (MR) vessel wall imaging (VWI). The pipeline consists of five modules, i.e., 1) MR angiography (MRA) to VWI registration, 2) vessel centerline tracking, 3) vessel straightening and cross-sectional slices generating, 4) deep learning -based vessel wall and lumen segmentation, and 5) plaque quantification. The pipeline achieved good to excellent reliability for the clinically relevant plaque measures and largely reduced the analysis time required for physicians.
Combined Modality PET/MR For the Detection of Severe Large Vessel Vasculitis
Authors: Cerne John , Liu Sophia , Umair Muhammad , Pathrose Ashitha , Savas Hatice , Wilsbacher Lisa , Moore Jackson , Markl Michael , Carr James , Avery Ryan
Published: August 2023

Combined modality PET/MR may be a sensitive modality to detect severe large vessel vasculitis. To distinguish severe large vessel vasculitis, a qualitative review of PET imaging findings appears more useful than standardized uptake values of a patient’s highest-uptake vessel. Inflammatory marker levels and trends, as well as single-modality scan findings, were not significantly different between severe and non-severe large vessel vasculitis patients.
Evaluation of a Novel Manganese-Based Contrast Agent for Cardiac MRI in the Setting of Myocardial Ischemia-Reperfusion
Authors: Bonner Benjamin , Coll-Font Jaume , Yurista Salva , Foster Anna , Eder Robert , Chen Shi , Caravan Peter , Gale Eric , Nguyen Christopher
Published: August 2023

Cardiac MRI a powerful imaging modality to assess cardiac anatomy and function, and its utility can be greatly enhanced with the use of contrast agents. Conventional contrast agents are nephrotoxic which limits their utility. We evaluate a novel contrast agent which is safe for use in renal dysfunction. We compare its performance against that of a conventional agent a porcine model of ischemia-reperfusion. This novel contrast agent demonstrates equivalent performance in assessing myocardial fibrotic scars, indicating its potential clinical use in the workout of cardiac patients with renal impairment.
Open source MATLAB code for the generation of digital reference objects for DCE-MRI analysis software validation
Authors: Gill Andrew , Graves Martin
Published: August 2023

Extending work by the QIBA initiative and others, a method is presented here for the generation of configurable digital reference objects (DROs) for the validation of dynamic-contrast enhanced (DCE-) MRI analysis software packages. Five commonly used kinetic models are supported and two software analysis packages were independently tested, one open source and one commercial. A sample set of DROs yielded excellent concordance with ‘ground-truth’ when analyzed with each package, indicating the software’s correctness and providing a benchmark for testing newly written software. Our MATLAB code is provided on an open-source basis to help researchers evaluate and test DCE-MRI analysis software.
Manifold-based Respiratory Phase Estimation Enables Motion and Distortion Correction of Free-Breathing Cardiac Diffusion Tensor MRI
Authors: Coll-Font Jaume , Chen Shi , Eder Robert , Fan Yilin , Han Qiao , van den Boomen Maaike , Sosnovik David , Mekkaoui Choukri , Nguyen Christopher
Published: August 2023

For in-vivo cardiac diffusion-tensor MRI (DT-MRI), respiratory motion and B0 field inhomogeneities produce misalignment and geometric distortion in diffusion weighted images acquired with conventional single shot echo planar imaging. We propose using Laplacian Eigenmaps (LE), a dimensionality reduction method, to retrospectively estimate the respiratory phase of DWI and facilitate both distortion correction (DisCo) and motion compensation (MoCo). LE-based DisCo and MoCo reduces geometric distortion by 13.2% while producing computationally efficient image alignment. Furthermore, preliminary results indicate the LE-based DisCo and MoCo can be applied with only acquiring a single set of b-value averages.
Test-Retest Reproducibility of Cerebrovascular Dual-venc 4D Flow MRI
Authors: Moore Jackson , Zvolanek Kristina , Aristova Maria , Abdalla Ramez , Ragin Ann , Russell Eric , Caprio Fan , Ansari Sameer , Schnell Susanne , Markl Michael
Published: August 2023

Cerebrovascular dual-venc 4D Flow MRI has utility in evaluating intracranial hemodynamics - benefitting from full circle of Willis (CoW) volumetric coverage, time-resolved, three-directional velocity encoding, and velocity dynamic range. Analysis of hemodynamic measures was completed using a comprehensive, semi-automated vessel identification and segmentation workflow for 10 subjects who underwent two scans within 30 days. Test-retest analysis of cerebrovascular dual-venc 4D Flow MRI and measures of CoW 3D flow dynamics demonstrated excellent repeatability for flow and peak velocity measures and lower reproducibility for pulsatility and resistive indices. Future work may include a larger cohort or more advanced analysis of velocity-derived parameters.
3T MRI Graph Analysis of the Proximal Femur trabecular network in Osteoporosis Subjects with Compared to Those without Prior Fragility Fractures
Authors: Monga Anmol , Martel Dimitri , Honig Stephen , Chang Gregory
Published: August 2023

Detecting microstructural information in bones leads to improved diagnosis, monitoring, and understanding of osteoporosis in patients. Recent advances allow for comprehensive and automated mining of quantitative image features to capture disease characteristics. Among these, graph and network analysis permit to characterize and assess network as the trabecular one and been previously applied in the wrist. In this study, we aim to apply the graph and network analysis method to the femoral trabecular bone network of osteoporosis subjects with and without previous fragility fracture history and assess features associated with fracture.
Bone-marrow fatty-acids profiles from women calcaneus by 1H-MR Spectroscopy to search early osteoporotic biomarkers
Authors: Mattioli Daniele , Vinicola Vincenzo , Montuori Marco , Tarantino Umberto , Capuani Silvia
Published: August 2023

Changes occurring in the bone-marrow fatty-acids (BMFA) could be precursors of the bone mineral loss due to the development of osteoporosis. In this view, early biomarkers of osteoporosis among BMFA could be highlighted by quantifying fatty-acids with 1H-MRS in young, premenopausal, postmenopausal women with normal t-score and in osteoporotic women. In this study, L13, L09, fUFA, and fPUFA together with TL quantification obtained in women calcanei could be early osteoporosis markers. The present work confirms the potential of MRS to investigate BMFA metabolic variations due to postmenopause and to the development of osteoporosis.
Parameters associated with durable clinical success in a multi-center trial using MR guided focused ultrasound treat uterine leiomyomas
Authors: Bitton Rachel , Fast Angela , Hesley Gina , Raman Steven , Matsumoto Alan , Dolan Eric , Kohi Maureen , Price Thomas , Fenessey Fiona , Ghanouni Pejman
Published: August 2023

This study presents results of a prospective multicenter clinical trial of 99 women treated with MR guided focused ultrasound (MRgFUS) for symptomatic uterine leiomyomas to assess treatment durability and to evaluate potential demographic, imaging, and technical characteristics associated with lasting clinical outcomes. Following treatment, there was an improvement in symptoms, with a significant decrease in mean symptom severity score at the 6, 12, 24 and 36 month follow up (p<0.001). In a multivariate model, a new parameter of interest, the ratio of non-perfused volume to total fibroid volume (NPV/TFV) was found to be predictive of durable clinical success (p=0.03).
Rapid Parameter Estimation for Combined Spin and Gradient Echo (SAGE) Imaging
Authors: Sisco Nicholas , Keeling Elizabeth , Borazanci Aimee , Dortch Richard , Stokes Ashley
Published: August 2023

In this study, we propose a generalized linear solution to estimate dynamic relaxation parameters R2* and R2 from combined spin- and gradient-echo (SAGE) MRI. We compared linear least squares (LLSQ) to nonlinear least squares (NLSQ) using Monte-Carlo simulated data and in vivo whole-brain data with varying signal-to-noise ratios (SNR). We show that using the LLSQ is both computationally more efficient and retains NLSQ precision, producing nearly the same estimates of R2* and R2 in a fraction of the time. This approach is widely extendable to other multi-echo, multi-contrast MRI methods, with applications including both perfusion MRI and functional MRI.
A data-driven variability assessment of brain diffusion MRI preprocessing pipelines
Authors: Veraart Jelle , Christiaens Daan , Dai Erpeng , Edwards Luke , Golkov Vladimir , Mohammadi Siawoosh , Schilling Kurt , Aarabi Mohammad Hadi , Ades-Aron Benjamin , Adluru Nagesh , Ahmad Sahar , Aja-Fernandez Santiago , Alexander Andrew , Andersson Mariam , Ansorena Elixabete , Attar Fakhereh , Attye Arnaud , Aydogan Dogu , Baete Steven , Basile Gianpaolo , Bertò Giulia , Beyh Ahmad , Cacciola Alberto , Chamberland Maxime , Calamante Fernando , Chen Jenny , Chen Jian , Chong Shin Tai , Coelho Santiago , Concha Luis , Coronado-Leija Ricardo , Cottaar Michiel , Cremers Daniel , David Szabolcs , De Luca Alberto , Dell'Acqua Flavio , Dhollander Thijs , Druzgal Jason , Dyrby Tim , Enedino Hernández-Torres , Esteban Oscar , Fieremans Els , Fonville Leon , Fricke Björn , Froeling Martijn , Galea Ian , Girard Gabriel , Grussu Francesco , Hsu Chin-Chin , Hsu Yung-Chin , Huynh Khoi , Inglese Matilde , Johansen-berg Heide , Jones Derek , Kamiya Kouhei , Kelly Claire , Khan Ahmad , Khan Ali , Kung Yi-Chia , Lazari Alberto , Leemans Alexander , Mancini Laura , Maximov Ivan , Merisaari Harri , Molendowska Malwina , Newman Benjamin , Noseworthy Michael , Novikov Dmitry , Perez-Lopez Raquel , Pestili Franco , Pieciak Tomasz , Pizzolato Marco , Planchuelo-Gómez Álvaro , Polak Paul , Raven Erika , Rios-Carrillo Ricardo , Sairanen Viljami , Schiavi Simona , Seow Pohchoo , Shastin Dmitri , Shih Yao-Chia , Soustelle Lucas , Sun Yue , Tabelow Karsten , Tax Chantal , Theaud Guillaume , Vos Sjoerd , Wade Ryckie , Wang Li , Wang Limei , Welton Thomas , Westlye Lars , Winzeck Stefan , Yang Joseph , Yap Pew-Thian , Zou Yukai , McNab Jennifer , Landman Bennett , Weiskopf Nikolaus , Descoteaux Maxime
Published: August 2023

The preprocessing of dMRI data sets is a critical step in the experimental workflow that, in general, improves the data reliability. We provide a comprehensive survey of the preprocessing workflows for dMRI data within our research community, assessing their variability and quantifying its impact on the dMRI metric reproducibility and inter-site comparisons. We observed that the lack of a standardized preprocessing pipeline across researchers is a significant source of variability that might lower the reproducibility of studies. These preliminary results highlight the need for harmonization of the image preprocessing workflow for dMRI data to promote more robust and reproducible analyses.
Automatically determine an optimal smoothing level in fMRI data analysis.
Authors: Zhuang Xiaowei , Yang Zhengshi , Curran Tim , Nandy Rajesh , Lowe Mark , Cordes Dietmar
Published: August 2023

To improve the accuracy of subject-level activation detections in noisy fMRI data, models to optimize voxel-wise smoothness levels for both isotropic Gaussian filter and spatially adaptive steerable filters are proposed. The smoothing step with currently optimized FWHM is incorporated into the optimization algorithm and solved efficiently using a sequential quadratic programming solver. Results from both simulated data and real episodic memory data indicate that a higher detection sensitivity for a fixed specificity can be achieved with the proposed method as compared to the widely used univariate general linear models with various levels of smoothness.
High-Resolution Brain Metabolite T2 Mapping Using Optimized Multi-TE MRSI
Authors: Wang Zepeng , Li Yahang , Lam Fan
Published: August 2023

Metabolite T2 is recognized as an important physiological and disease biomarker, whose measurement also benefits metabolite quantification. However, the SNR challenge of MRSI and prolonged scan time for multi-TE acquisition limit the imaging resolution. This work presents an optimized multi-TE MRSI strategy to achieve high-resolution 3D brain metabolite T2 mapping. Specifically, estimation-theoretic TE selection was analyzed for optimized metabolite T2 estimation. An enhanced parameter estimation strategy was proposed. Both simulation and invivo studies were conducted to evaluate our method. The exciting capability of simultaneous high-resolution metabolite, neurotransmitter and T2 mapping is demonstrated for the first time.
Automated MRI k-space Motion Artifact Detection in Segmented Multi-Slice Sequences
Authors: Jang† Ikbeom , Frost† Robert , Hoffmann Malte , Singh Nalini , Chen Lina , Guidon Arnaud , Rockenbach Marcio Aloisio Bezerra Cavalcanti , Comeau Donnella , Bizzo Bernardo , Chang Ken , Witham Sage , Rettmann Dan , Banerjee Suchandrima , Brau Anja , Reese Timothy , Aganj Iman , Dalca Adrian , Fischl* Bruce , Kalpathy-Cramer* Jayashree
Published: August 2023

Motion artifacts negatively impact diagnosis and the radiology workflow, especially in cases where a patient recall is required. Detecting motion artifacts while the patient is still in the scanner could potentially improve workflow and reduce costs by enabling efficient corrective action. We introduce an algorithm that detects motion artifacts directly from raw k-space in a supervised learning manner in clinically important 2D FSE multi-slice scans, using cross-correlation between adjacent phase-encoding lines as features. This study employs a training approach that uses a motion simulator to generate k-space data with varying levels of motion artifact.
MC-ECLIPSE for arbitrary ROI shaping and whole brain shimming for 3D MRSI
Authors: Kumaragamage Chathura , Brown Peter , McIntyre Scott , Nixon Terence , De Feyter Henk , de Graaf Robin
Published: August 2023

ECLIPSE, a pulsed second order gradient insert can provide robust lipid suppression over an elliptical ROI for applications in human brain MRSI. While ECLIPSE provides excellent axial slice coverage for brain shapes that closely resemble an ellipse, coverage can be compromised for other head shapes. The development of an ECLIPSE gradient coil in combination with a 54-channel multi-coil array (MC-ECLIPSE), that allows B0 field shaping for arbitrary ROI generation is presented. Simulation results demonstrate that near-perfect (99%) axial slice coverage is achievable with MC-ECLIPSE, for a wide range of highly asymmetrical brain and head shapes.
Improving the performance of integrated RF-B0 shim array using 3D coil elements with orthogonal loops
Authors: Li Siyu , Wang Danny
Published: August 2023

B0 field inhomogeneity can reduce the effectiveness of RF pulses, result in signal voids, blurring and image artefacts. Integrated RF-shim coil arrays1,2,3 offer capabilities for concurrent parallel RF reception and local B0 shimming, and is superior to spherical harmonic shimming. However, its performance may still be limited due to the lack of flexibility for shimming and limited depth penetration for signal reception. We simulated the B0 shimming performance of a range of integrated RF-shim coil arrays with 3D orthogonal loop coil geometry, and compared the results with standard 2D loop coil arrays.
Modular, 3D Printed, Open-source Phantoms for Small Animal Systems
Authors: Gardiner Mariko , Tessier Anthony , Wachowicz Keith , De Zanche Nicola
Published: August 2023

Phantoms for pre-clinical systems have not been standardized, and none in the literature permit the wide variety of measurements possible with the ACR phantoms. We present a low-cost, open-source, modular phantom made of 3D-printed and off-the-shelf parts that mimics the functionality of the ACR phantoms on an appropriate scale. Standard, inexpensive manufacturing techniques are sufficient to create the fine features required at this scale. Configuration of the phantom can be customized to suit each site’s needs. Possible measurements include image uniformity, distortion and SNR; slice location, thickness, and angle; radial, linear, and low-contrast resolution.
A conclusion on how computer-aided localization of a breast lesion impact Breast MRI-guided biopsies when compared with manual localization techniques
Authors: Toni Larowin , Vernikov Galina , Smelianskaia Olga , Bryce Yolanda
Published: August 2023

Patients with suspicious lesions on MRI that cannot be detected with another modality may undergo MRI guided biopsy. The MRI biopsy may induce anxiety and may be uncomfortable with the breast in compression which may be exacerbated by the length of the procedure. Software has been developed by certain companies to streamline and increase ease of the MRI-guided biopsy. We performed a study to see if this software decreases the length of the procedure. We also will see if software leads to differences recommendation, concordance, and subsequent cancer if the biopsy was benign.
Are low dose CT scouts suitable for MRI safety screening of subjects with unknown medical history?
Authors: Barnsley Hannah , Uzoukwu Sam , Borri Marco
Published: August 2023

Increasing numbers of patients are presenting for MRI who cannot complete the safety questionnaires. CT scout images have low radiation dose, and are faster and easier to acquire compared to plain film x-rays, the recommended modality for MR safety screening for patients with unknown history. This study assesses the performance of CT scout images in detecting and identifying a range of head/neck and body implants. Using 40 head/neck and 40 body CT scouts, two Readers reviewed the images for possible internal implants. 88% of implants were found and correctly identified, concluding that the majority of visible implants are detectable.
Evaluating Preparation Methods for Clinical MRI Scans in Young Children without Anesthesia
Authors: Sherriff Marty , Fletcher Sarah , Lardner David , Bagshawe Mercedes , Carsolio Lisa , Smith Cathy , Lebel Catherine
Published: August 2023

We compared the efficacy of three different preparation methods for clinical MRI scans without sedation in young children (3-7 years): at-home resources, a session with a child-life specialist, or a mock MRI session with a child life specialist. Success rates were excellent at 91%, with no differences between training groups. Subtle group differences in fear/anxiety ratings suggest a slight benefit of the mock MRI session in reducing anxiety before scans.
IMPLEMENTASI KOMUNIKASI EFEKTIF DALAM PENGISIAN GENERAL CONSENT DI TPP RSUD KABUPATEN JOMBANG
Authors: Soraya Soraya , Nayotama Hafiz , Murni Tri
Published: August 2023

Background: Effective communication is a communication that is able to produce attitude change in the people involvedin the communication. General Consent sheet is a consent sheet given to the patient or family after receiving a completeexplanation from the registration officer.Objective : The purpose of this study was to find out whether the officers at the Patient Registration Center had appliedeffective communication in explaining the content and purpose of the General Consent to patients.Methods : This type of research used a descriptive method with a quantitative approach. Researchers used data collectiontechniques with questionnaires which were distributed to 68 patients and 4 officers at TPP Jombang District Hospital.Results : The level of understanding of officers about the SOP for filling in General Consent only has a percentage of25%. The level of patient understanding of filling out the General Consent. related to filling in the Name on the GeneralConsent sheet has a percentage of 97%, filling in Medical Record Number Medical Record has a percentage of 88.2%,filling out a statement for payment has a percentage of 90%, filling in locqtion, date and time has a percentage of 85%,filling in a signature and clear name has a percentage of 88%, filling in the witness's signature has a percentage of 88%and finally the signature of witnesses from the patient's family has a percentage of 97%. The implementation of effectivecommunication between officers and patients in filling out General Consent was apparently has not optimal and onlyhad an average score below 50.Conclusion : From the results of the study, the researchers found that effective communication between staff andpatients at the TPP RSUD Jombang Regency had not been implemented properly. delivery of information or thoughtsregarding the patient's condition, medical and non-medical actions, treatment plans and the patient's rights andobligations while being treated or carrying out an examination at the hospital.
“Tog ni emot helig Ande när ni kom till tro?” (Apg 19:2)
Authors: Johansson Simon
Published: August 2023

N/A
Kemampuan Siswa Kelas V dalam Menyelesaikan Soal Materi Pengelolahan Data di SD Negeri Curug II
Authors: Unaenah Een , Anggraeni Ani Nur , Wahyu Rahma Rizkiya
Published: August 2023

This study aims to describe the understanding of grade 5 students in learning data processing and to identify the types of errors that are often made by students. This study originates from the law of the Ministry of Learning of the Republic of Indonesia, No. 57 in 2014 on demonstrating essential skills of mathematics in specialization development, communication and life adjustment. This study used full-time and student checks of 34 students from SD. Data was collected through interviews, questionnaires and tests. Data processing includes making tables, line diagrams and bar diagrams. The results of the study show that students' understanding of data processing still needs to be improved. Common errors are conceptual errors, data usage errors, data interpretation errors, technical and input errors. Errors in the conclusions listed are common errors. Data processing education should be improved by providing a better understanding of basic data processing concepts and teaching students the proper way to use, interpret, and present data. It is also important to choose learning methods that are interactive, relevant and interesting to students. This research helps improve computer science education in grade 5 elementary schools and informs more effective learning efforts to improve students' understanding of mathematics.
The Influence of Leadership and Knowledge Sharing on Employee Performance through the Quality of Human Resources in the Investment Office and One-Stop Integrated Services
Authors: Buyung Arma Andi , Ansar Ansar , Hasmin Hasmin , Gunawan Gunawan
Published: August 2023

This study aims to determine and analyze the Influence of Leadership, Knowledge Sharing and HR Quality on Employee Performance with the object of research at the Office of Industry and Trade. This research is quantitative research. Data analysis techniques using Path analysis. The results of the study by testing the hypothesis using the calculated t value and significance based on the Path analysis model, concluded that; (1) Leadership has a significant effect on Employee Performance, showing significant results with a path coefficient of 0.283 (positive) and a significance value (p-value) of 0.013 (less than 5%); (2) Knowledge Sharing has a significant effect on Employee Performance, showing significant results with a path coefficient of 0.254 (positive) and a significance value (p-value) of 0.027 (less than 5%); (3) Leadership has a significant effect on HR Quality, showing significant results with a path coefficient of 0.499 (positive) and a significance value (p-value) of 0.000 (smaller than 5%); (4) Knowledge Sharing has a significant effect on HR Quality, showing significant results with a path coefficient of 0.506 (positive) and a significance value (p-value) of 0.000 (smaller than 5%); (5) HR quality has a significant effect on Employee Performance, showing significant results with a path coefficient of 0.380 (positive) and a significance value (p-value) of 0.005 (smaller than 5%); (6) Leadership has a significant effect on Employee Performance through HR Quality showing significant results with a coefficient of 0.190 (positive) and a significance value (p-value) of 0.0092 (smaller than 5%); (7) Knowledge Sharing has a significant effect on Employee Performance through HR Quality, showing significant results with a coefficient of 0.192 (positive) and a significance value (p-value) of 0.0089 (smaller than 5%).
Implementation of The Rehabilitation Model on Victims of Drug Abuse in The Development of The Legal System in Indonesia
Authors: Ali Syaifudin Mohamad , Sulaiman Abdullah , Multiwijaya Vientje Ratna
Published: August 2023

Drug abuse is usually initiated by the use of trial and error just following friends to reduce or eliminate pain, fatigue, mental tension, or as entertainment or for association. The problem of differences in perception in the implementation of Law of the Republic of Indonesia Number 35 of 2009 concerning Narcotics, especially regarding rehabilitation for novice drug users. The purpose of this study is the regulation of the rehabilitation process for novice users or victims of drug abuse and addicts in the Indonesian legal system. The reconstruction of law enforcement in legal cases against novice users, addicts and drug abusers at this time, an ideal model for the concept of drug rehabilitation in the development of the Indonesian legal system. Using empirical legal research where a legal research method that uses empirical facts taken from human behavior, both verbal behavior obtained from interviews and real behavior carried out through direct observation. The results of the study include the regulation of the rehabilitation process for novice users or victims of drug abuse and addicts in the Indonesian legal system, it is hoped that there will be legal reform in the Indonesian legal system where legal reform according to the author is a comprehensive and multidimensional handling effort in order to achieve maximum results, and eradication efforts must be carried out gradually, consistently, and continuously. Law enforcement reconstruction in legal cases against novice users, addicts and drug abusers at this time there is still a gap in the legal process in law enforcement in narcotics crimes, law enforcement officials, especially the Police in the assessment process against perpetrators of drug abuse, should not distinguish the social status of perpetrators who will carry out integrated assessments or examinations in terms of knowing the perpetrators as users or dealers Narcotics, according to the author, drug addicts are not real drug offenders but dealers who should be eradicated because they are the real perpetrators of crimes in narcotics because if drug addicts are not given rehabilitation forever the addict will continue to be victims of drug dependence. The ideal model for the concept of narcotics rehabilitation in the development of the Indonesian legal system is expected to have legal synchronization between 3 (three) law enforcement elements, namely the Police, the Prosecutor's Office and the Panel of Judges in the Court handling narcotics abuse cases requiring making primary or primary charges with Article 127 of the Narcotics Law. Suggestions include
Acute pancreatitis caused by Systemic Lupus Erythematosus activity: A case report and literature review
Authors: Velasque Marques Eduardo , Cerqueira Batista Filho Luiz Alberto , Toledo Maciel Alexandre
Published: August 2023

A 32-year-old woman with systemic lupus erythematosus came to the rheumatology outpatient clinic reporting abdominal pain for a week, along with fever, arthralgias, myalgias, alopecia, asthenia and dyspnea on exertion over the last two months. She was hypotensive and tachycardic, requiring admission to the intensive care unit. She was diagnosed with lupus-related acute pancreatitis, an unusual complication occurring in less than 1% of cases. Most cases are mild and self-limited; however, severe and life-threatening events with multiple organ failure are possible. This article is a case report of lupus-related critical acute pancreatitis, and a literature review.
Colorectal cancer epidemiology in Tanzania: patterns in relation to dietary and lifestyle factors
Authors:   , Kamanga Leonard
Published: August 2023

Chronic non-communicable diseases are increasingly captured as contributing to morbidity and mortality in low and middle income countries. This study has designed to investigate the epidemiology of colorectal cancer and the potential modifiable local risk factors in Tanzania. A cross sectional retrospective chart audit study was conducted to establish the pattern and distribution of colorectal cancer, The Food Frequency Questionnaire and the Step® survey tool were used to collect data. Descriptive statistics, Chi square tests and regression analysis were employed and augmented by data visualization to display risk variable differences. Tanzania‘s colorectal cancer incidence has increased six times in the last decade in which major towns and cities of Dar es Salaam (20.2 per 100 000), Pwani (7.2 per 100 000), Kilimanjaro (4.4 per 100 000), Arusha (4.2 per 100 000) and Morogoro (3.6 per 100 000) had the highest percentage. This study reported that, almost 45% of the participants were hypertensive. Two major dietary patterns, namely ―healthy‖ and ―western‖, existed among the study sample. Obesity was found in 25% of participants, whereas overweight was present in 28%; of note, the prevalence was higher in females (26.9%) than in males (23.6%) respectively. The prevalence of alcohol consumption was 21.5%, with a significantly lower rate of smoking (12.2%) noted within the study subjects. Both alcohol consumption and tobacco smoking were more common in men than women (22.7 vs. 20.6% and 24.5 vs. 3.2%, respectively). The prevalence of vigorous, moderate, and low physical activity for both sexes was 18.6%, 54.1% and 42.3%, respectively. Evidence from this study demonstrated that, lifestyle factors, such as diet, obesity, tobacco smoking, alcohol consumption, and sedentary behaviors, have a significant role in the rising trend of non communicable diseases and colorectal cancer in Tanzania. We recommend a large longitudinal study with robust methodology which can establish cause and effect relationships between specific lifestyle behaviors and the prevalence of colorectal cancer.
Dermatologic Manifestations of Common Zoonotic Exposures
Authors: Bludorn Janelle , Palmer Erica , Braima Andre
Published: August 2023

Snakes, spiders, and ticks are among the most common creatures in the United States whose bites can lead to serious medical complications. Although the systemic sequelae are often nonspecific, many of these zoonotic exposures exhibit specific dermatologic manifestations that can be key to their diagnosis and treatment. The goal of this article is to increase clinician knowledge and skill in identifying the dermatologic findings of several snake-, spider-, and tick-borne conditions in order to provide prompt disease-specific medical treatment.
Beyond the Surface: The Psychosocial Effects of Atopic Dermatitis
Authors: Mudd Kara
Published: August 2023

Purpose

The purpose of this article is to review the psychosocial effects of atopic dermatitis. It is important for providers to identify the psychosocial comorbidities associated with atopic dermatitis to provide well rounded patient care.

Method

A PubMed literature search was conducted with search terms “atopic dermatitis,” “psychosocial,” and “comorbidities.” Filters were set to articles published after 2015 and limited to clinical and systematic reviews, meta-analysis, and clinical trials. This yielded nine articles. A second search was performed using the terms “atopic dermatitis,” “anxiety,” and “depression” with similar parameters and 41 studies were revealed. Additional searches were performed in Medline and the Cochrane library with the same key terms.

Results

Several quality studies showed that atopic dermatitis is associated with increased risk of anxiety, depression, attention deficit hyperactivity disorder, suicidality, and decreased quality of life. Additional research is needed to determine the relationship between atopic dermatitis and obsessive-compulsive disorder, and schizophrenia. Many studies proposed pruritus and sleep deprivation as primary factors in increasing mental health comorbidities of atopic dermatitis.

Conclusion

Dermatology providers should screen for associated comorbidities of atopic dermatitis and refer for appropriate treatment as necessary. Aggressive treatment of atopic dermatitis can improve overall quality of life and subsequently lessen the rate of associated comorbidities.
A Survey of Nurse Practitioner and Physician Assistant Advanced Practice Providers Uncovers a Need for Precision Medicine in Psoriasis Management
Authors: Harkiewicz Adam , Martin George , Dickerson Tobin J. , Deren-Lewis Ann
Published: August 2023

Objective

The arrival of biologics has considerably improved the treatment of psoriasis and psoriatic arthritis; however, it can be difficult to identify which biologic(s) a patient will respond to without undergoing a trial-and-error approach. The current survey was designed to investigate biologic switching in the clinic and whether a biomarker test would assist in selecting the appropriate treatment for patients and improve psoriasis management.

Methods

A survey of 157 nurse practitioner and physician assistant (NP/PA) advanced practice providers was conducted to assess (1) the frequency of biologic switching and (2) the perceived clinical utility of a biomarker test that stratifies psoriasis patients to predict biologic response.

Results

More than half of advanced practice providers (55%) indicated that psoriasis patients require at least two different biologics to achieve an adequate response to treatment, with 59% of respondents specifying that 10% to 30% of their patients switch biologics the first year of treatment. Ninety-six percent of respondents indicated that a biomarker test would likely improve their practice, with the majority of participants (84%) suggesting a biomarker test could improve their ability to determine the most appropriate therapy for their patients. Ninety-one percent indicated they would use a biomarker test (Mind.Px, Mindera Health, San Diego, California), and 63% said they would perform the test in their office.

Conclusions

A biomarker test may help shift psoriasis management from a trial-and-error approach to precision care, thereby reducing the time to effective treatment and improving patient outcomes.
Sumatera Thawalib
Authors: Abbas Afifi Fauzi
Published: August 2023

Reformasi Pendidikan Islam di Tanah Melayu, Sumatera hingga semenanjung Melayu (Malaysia), Brunei dan Bugis, tidak bisa dipisahkan dari peranan institusi pendidikan Sumatera Thawalib, peranannya mereformasi pendidikan islam dari sistem halaqah (surau) ke sistem kelas (klasikal) membawa perubahan signifikan dalam pengembangan pendidikan dan pengembangan sumber daya manusia pada saat itu. Surau Jembatan Besi, Surau Parabek, Surau Padang Japang, Surau Sungayang dan Surau Maninjau adalah lima perguruan yang diasuh dan dikelola oleh kaum muda.
Hamka dan Fatwa Natal 1981
Authors: Abbas Afifi Fauzi
Published: August 2023

Membicarakan masalah kehidupan sosial keagamaan di Indonesia memang tidak ada habis-habisnya, apalagi kita semua menyadari bahwa kita bangsa Indonesia hidup di tengah-tengan masyarakat yang plural dan majemuk yang meyakini berbagai agama, terdiri dari berbagai etnis, kultur dan budaya yang beragam. Perayaan natal di Indonesia meskipun tujuannya merayakan dan menghormati nabi Isa AS, akan tetapi natal itu tidak dapat dipisahkan dari soal-soal yang diterangkan di atas, bahwa perayaan Natal bagi umat Kristen adalah merupakan ibadah. Pluralisme termasuk gagasan yang sedang aktual diperbincangkan. Para pakar dari berbagai disiplin ilmu dan para pemerhati berusaha menyumbanghkan pemikiran mengenai bagaimana menata kehidupan bangsa Indonesia yang pluralistis. Hal yang sama dilakukan pula oleh sejumlah praktisi. Mereka menuturkan pengalamannya yang patut untuk dicermati dalam membina kehidupan masyarakat secara langsung. Tujuannya adalah untuk memelihara keharmonisan dan kesatuan bangsa. Tulisan dipersiapkan pada tahun 2006 untuk diskusi panel HAMKA dan Fatwa Natal MUI 1981 oleh UHAMKA, dan belum pernah dipublikasi sebelumnya.
Understanding True Religion as Ethical Knowledge
Authors: Afifi Abdullah A
Published: August 2023

Hatred, extremism, terrorism and islamophobia become challenges for religion nowadays. The weight of this issue burdens the understanding of society about religion. Either to be a secular atheist or alienated religious extremist are not an appropriate solution. Alternatively, an approach needed to define religion as the source of ethical knowledge and facilitated the construction of new tolerance that not exclude the religion from people’s affair. This paper discusses the true religion and how they construct ethical knowledge used for the development of civilization.
Worldview Islam dalam Aktualisasi Moderasi Beragama yang Berkemajuan di Era Disrupsi Digital
Authors: Afifi Abdullah A , Abbas Afifi Fauzi
Published: August 2023

The development of one's understanding will be very relevant to efforts to make improvements and changes. Worldview Islam means that Muslims use their religious understanding in actualizing progressive and constructive religious moderation which can balance the effect of digital disruption. Digital disruption has brought about an era filled with challenges, crises and threats. On the other hand, it provides hope, a great opportunity for the dissemination of knowledge, especially in the context of Muslims as agents of moderation and drivers of civilization. This article contains how Muslims need to formulate ways and future agendas to develop an Islamic worldview by enriching the tarjih method to actualize progressive religious moderation in an era of digital disruption in every sector. Digital disruption should be able to provide added value from the actualization of modern Muslims who are still able to align it with the guidelines from the al-Quran and as-Sunnah. Digital disruption should be able to become a medium for increasing public literacy towards the universal ethical values ??offered by Islam.
Granting Cultivation Rights on Communal Land According to Indonesian Land Law
Authors:   Master of Notary, Faculty of Law, University of Jember, Ramadhan Alif Mahfira , Ciytayasa Wisnu Putra ,   Master of Notary, Faculty of Law, University of Jember, Ramandhan Putra Desantha ,   Master of Notary, Faculty of Law, University of Jember
Published: August 2023

Land law in Indonesia regulates the customary rights of customary law communities. Communal rights were only recognised by the Minister of Agrarian Affairs and Spatial Planning Regulation No. 10/2016 on Procedures for Determining Communal Rights to Land of Customary Law Communities and Communities Located in Certain Areas. The regulation, which is expected to be a guideline in resolving conflicts between indigenous peoples, actually creates a conflict of norms. Through the National Land Agency, the government issued communal rights certificates as recognition and respect for customary law communities in West Papua. This shows that communal rights can be registered according to the laws and regulations in the field of land registration. In addition, the land can be cooperated with third parties or investors by granting Cultivation Rights or Building Rights. With this, it is necessary to study further the granting of communal rights certificates according to land law in Indonesia and the Right to Cultivate on communal land according to land law in Indonesia.
Dividend Decisions and Financial Performance of Listed Firms: Evidence from Developing Countries
Authors:   Department of Accounting, Faculty of Management Sciences Kaduna State University, Kaduna, Nigeria, Ismaila Hassan, , Tanko Hassan Alhaji, ,   Department of Accounting, Faculty of Management Sciences Kaduna State University, Kaduna, Nigeria
Published: August 2023

Many listed firms in developing countries are not performing well. There are other factors that may affect their performance; however, the study reviewed the past studies on the impact of dividend decisions on financial performance of listed firms: Evidence from developing countries. While the results of some past studies on the impact of dividend decisions on listed firms in developing countries revealed that the dividend decisions had a positive significant impact on financial performance, others showed that dividend decisions had a negative significant impact on financial performance of listed firms in developing countries. Thus, the study recommends that the management of listed firms in developing countries should continue to pay dividends to their investors on regular basis with a reasonable amount whenever they make reasonable profits in order to retain the existing investors and at the same time attract new ones and by so doing the share price of their firms will appreciate in value.
Developing Website for Belimbing Tourism Village, Tabanan, Bali
Authors: Dewi Ni Wayan Sintya , Sutama I Ketut , Murni Ni Gst Nym Suci , Sudiarta Made
Published: August 2023

Purpose: The purpose of this research is to evaluate the Belimbing Village website in development efforts website by model information, communication, transaction, relationship and techical-merit (ICTRT) carried out to support the Belimbing Tourism Village produces dimensions of effectiveness website the maximum in helping the promotion of Belimbing Tabanan Tourism Village.

Research methods: The data collection methods used were observation, interviews, questionnaires and interviews. In this study using qualitative and quantitative approaches or better known as mixed method research by using SWOT analysis techniques and Importance Performance Analysis.

Findings: The results of the research using the interview method show that the application website in Belimbing Village is still very minimal because there are many features and items that need to be developed, one of which is the information dimension, transaction dimension and communication dimension. The results of the study using SWOT analysis showed that Belimbing Village has utilized ICT, but even though it has implemented ICT there are still many aspects that are lacking in website, so that more in-depth research is needed to assess its effectiveness in website Belimbing Village. Based on analysis Importance Performance Analysis produce effectiveness attributes. The researcher adopted the ICTRT model which consisted of 47 evaluation instruments which were divided into 5 evaluation dimensions.

Implication: Site evaluation website expected to maximize promotion through website in Belimbing Village because website is an effective solution to introduce and market products/services by utilizing the internet as an information medium.