bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposição de modelos de geração de viagens para Belo Horizonte
Authors: De Oliveira Leise Kelli , Stubbs Luciana Carneiro de Morais , Gontijo Nebai Tavares , Oliveira Renata Lúcia Magalhães de
Published: August 2017

Este artigo apresenta modelos de geração de viagens para sete categorias de empreendimentos (casas noturnas, condomínios residenciais, escolas de ensino fundamental e médio, hospitais, instituições de ensino superior, shopping centers e supermercados) para Belo Horizonte. Contagem classificada volumétrica de veículos, entrevistas e dados de controle de acesso foram utilizados para identificar as características dos empreendimentos e desenvolver os modelos. Os modelos desenvolvidos apresentaram boa correlação entre as variáveis utilizadas e significância estatística, exceto para condomínios residenciais e supermercados. A validação dos modelos indicou uma boa aproximação com os dados coletados em campo. A comparação com os modelos da literatura nacional indicou que investigar e desenvolver estudos para uma cidade é importante quando há necessidade de utilizá-los em estudos de impacto viário para determinação de medidas mitigadoras na implantação dos empreendimentos de impacto. Desta forma, os modelos locais são mais precisos e tendem a produzir menores erros na projeção, permitindo uma avaliação mais confiável e adequada das medidas mitigadoras necessárias para o empreendimento.
Impactos de uma taxação ambiental sobre a demanda no transporte aéreo brasileiro
Authors: Resende Carolina Barbosa , Oliveira Alessandro Vinícius Marques de
Published: August 2017

Nos últimos anos, o tema das emissões de gases do efeito estufa e seus efeitos potencialmente danosos sobre o planeta entrou definitivamente na pauta de governos ao redor do mundo, com destaque aos encontros internacionais realizados que visaram acordar entre os países formas de equacionar o problema. Em se tratando de aeronaves, sabese que a queima do combustível as tornam fontes emissoras importantes de tais gases. Sabe-se que a taxação das passagens aéreas, por afetar diretamente a geração de viagens aéreas, tem potencial de atuar como instrumento arrefecedor de demanda e, por decorrência, do número de viagens e voos e, em última instância, do consumo de combustível. O presente trabalho visa quantificar essa relação, simulando a inserção de um imposto ambiental sobre o preço do querosene de aviação e seu impacto indireto sobre a demanda por transporte aéreo. Estimou-se, utilizando modelagem econométrica, que a demanda cairia frente a um aumento nos preços decorrente do imposto, mas que a reação ocorre de forma assimétrica conforme o mercado. Observou-se que rotas com perfil mais turísticos sofreriam uma redução de 6,06% para uma taxa de 10EUR, enquanto uma rota com perfil mais corporativo sofreria queda de 2,35% para mesma taxa.
The Revolution Will Be Working Class and Queer: Dos Passos’s Three Soldiers, Progressive Politics, and Revolutionary Rhetorics
Authors: Arnett James J.
Published: August 2017

Taking a look at the early, and in particular, the World War I novels of John Dos Passos, this article argues for the recognition and preservation of a revolutionarily ‘tender’ queer, working-class politics in those texts. Though scholars hardly agree that World War One was an explicitly queer or merely homosocial space, Dos Passos’s willingness to depict queer lives frankly and sympathetically earned criticism then, and critical silence now. This article probes Dos Passos’s early progressive politics as well as his significant rejection of them in the lead-up to World War Two, and argues that this reversal was not surprising, but may have led to the relative obscurity of these politics to even contemporary readers. Mobilizing recent radical queer politics described by Samuel Delany and theories of revolutionary love by Srecko Horvat, this essay argues that the inter-class contact, physical and social, creates the conditions whereby a challenge to capitalist alienation can be mounted by the men who emerge at these intersections.
Uji Kriteria Manajemen dalam Pengelolaan Air Limbah Domestik Terpusat
Authors: Siswati Muji , Syafrudin Syafrudin , Sriyana Sriyana
Published: August 2017

Sanitation infrastructure is one of the basic needs of society and has a strategic role in improving the health and welfare of the community. The Indonesian government has built centralized domestic waste water infrastructure in 13 cities until 2014. According to USAID (2006) and AusAID (2013), idle capacity and cost recovery in the centralized domestic waste water system is still a major problem. Therefore, it needs to be done assessment management criteria of centralized domestic waste water management. This research is done by three-stage, that is construction models of a relationship of interdependence between management criteria; assessment of model suitability that has been constructed using SEM method; and calculate the weight of each management criteria using ANP method. The management criteria used on this study consist of: performance management, technical, institutional, regulatory, financing, and public participation. The weight of each criteria using models that have been assessment for their suitability, are: performance management (75.37%), financing (8.83%), public participation (8.39%), technical (3.56%), regulatory (2.36%) and institutional (1:49%). The global weight of sub criteria with most critical weight and should be a priority concern are sustainability (48.20%), public acceptance (14.90% 0, reliability (9.30%), willingness to pay (5.20%), and cost recovery (4.62%).
Perubahan Pola Pergerakan pada Simpang Kalibanteng akibat Penerapan Manajemen Dua Arah pada Flyover
Authors: Wicaksono Y I , Indriastuti Amelia Kusuma , Riyanto Bambang
Published: August 2017

Kalibanteng Intersection is one of primary node in west part of Semarang City. It is a signalized intersection which shaped roundabout. It lies on the truck track from west to east of Java Island, which is crossed over by Flyover Yos Sudarso – Siliwangi and Flyover Sudirman – Siliwangi. Formerly, the flyover is designed for Siliwangi – Yos Sudarso vice versa. The flyover could decrease truck volume from east to west, on the contrary heavy vehicle movement is still overburden Kalibanteng Intersection capacity. On 2018, it is planned that Ahmad Yani Airport access road will be diverted. Thus, it is important to increase Kalibanteng Intersection performance, and accommodate the airport access divertion plan at a time. This research is aimed to identify the existing movement pattern at Kalibanteng Intersection, to evaluate the existing signalized intersection performance, to develop a simulation of two way management on Kalibanteng Flyover, to analyze the movement pattern due to the implementation of two way management on the flyover, and to analyze the signalized intersection due to this management. The results show that the highest movements in Kalibanteng Intersection are the movement from Siliwangi to Yos Sudarso (which is dominated by heavy vehicle) and from Siliwangi to Sudirman (which isi dominated by light vehicle and motorcycle), and will keep on increasing in the future. These movement greatly contribute on intersection performance. This shows that the utilization of the flyover for two-way movement can be considered with mode type limitation. Using two-way flyover, the performance of Kalibanteng signalized intersection will increase.
Model Simulasi Risiko Rantai Pasok Material Proyek Konstruksi Gedung
Authors: Hatmoko Jati Utomo Dwi , Kistiani Frida
Published: August 2017

Delays related to materials are one of main problems of construction project. An effective supply chain management has a significant role in preventing this type of delay. The aim of this research is develop risk simulation model of construction supply chain in buildings. The materials include steel bars, steel profiles, formwork, and precast concrete, as they are considered the main building material. The supply chain risks are classified from supply, control, process, and demand sides. Monte Carlo simulation has been performed using Cristal Ball software. Risk identification was done through literature review, site observation, and interviews with 29 contractor personnel  working for nine building projects. The simulation results show that the minimum, maximum, and most frequent delays (in days), as follows: steel bars (2.20. 17.05, 11.24); steel profiles (2.12, 15.10, 9.75), formwork (1.79, 16.04, 10.45), precast concrete (1.76, 15.61, 10.24).  The sensitivity analysis shows that delay due to change order from client is the most sensitive for  steel bars, steel profiles, and formwork of 25.5%, 37.4%, dan 17%, respectively. The results of this research is useful for contractors and owners who can use them as a guidance in identifying, predicting, and mitigating supply chain risks for a successful project.
Curcumin: Synthesis optimization andin silicointeraction with cyclin dependent kinase
Authors: Ahmed Mahmood , Abdul Qadir Muhammad , Imtiaz Shafiq Muhammad , Muddassar Muhammad , Hameed Abdul , Nadeem Arshad Muhammad , Asiri Abdullah M.
Published: August 2017

Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its rapid acquisition. During synthesis, solvent choice was found to be an important parameter for better curcumin yield and high purity. In a typical reaction, acetyl acetone was treated with boron trioxide, followed by condensation with vanillin in the presence of tri-n-butyl borate as water scavenger andn-butylamine as catalyst at 80 °C in ethyl acetate to afford curcumin. Moreover, curcumin was also extracted from turmeric powder and spectroscopic properties such as IR, MS,1H NMR and13C NMR with synthetic curcumin were established to identify any impurity. The purity of synthetic and extracted curcumin was also checked by TLC and HPLC-DAD. To computationally assess its therapeutic potential against cyclin dependent kinases (CDKs), curcumin was docked in different isoforms of CDKs. It was observed that it did not dock at the active sites of CDK2 and CDK6. However, it could enter into weak interactions with CDK4 protein.
Axonal excitability and conduction alterations caused by levobupivacaine in rat
Authors: Tuncer Seçkin , Tuncer Peker Tülay , Burat İlksen , Kiziltan Erhan , İlhan Barkin , Dalkiliç Nizamettin
Published: August 2017

In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction method over sciatic nerves of Wistar rats before and after administration of 0.05 % (1.7 mmol L−1) levobupivacaine. Levobupivacaine caused complete CNAP area and amplitude depression by blocking conduction in a time-dependent manner.

To assess the influence of levobupivacaine on in vivo excitability properties, threshold-tracking (TT) protocols were performed at sciatic nerves of rats injected with perineural 0.05 % (1.7 mmol L−1) levobupivacaine or vehicle alone. Charge-duration TT results revealed that levobupivacaine increases the rheobase and decreases the strength-duration time constant, suggesting interference of the anesthetic with the opening of Na+ channels. Twenty and 40 % threshold electrotonus curves were found for both groups to follow the same paths, suggesting no significant effect of levobupivacaine on K+ channels for either the fastest or relatively slow conducting fibers. Current-threshold relationship results revealed no significant effect on axonal rectifying channels. However, according to the results of the recovery cycle protocol yielding the pattern of excitability changes following the impulse, potential deviation was found in the recovery characteristics of Na+ channels from the absolute refractory period. Consequently, conduction blockage caused by levobupivacaine may not be due to the passive (capacitive) properties of axon or the conductance of potassium channels but to the decrease in sodium channel conductance.
Support of medication adherence by community pharmacists in Czech and Slovak Republics: a questionnaire survey study
Authors: Molitorisová M. , Kotlářová J. , Snopková M. , Waczulíková I.
Published: August 2017

Introduction: Intervention of pharmacists in medication adherence can meaningfully contribute to achieving therapeutic outcomes. Exploring the real-life readiness and opportunities of pharmacists may result in the adoption of measures, which could be seen through improvement of patients’ adherence to pharmacotherapy.

Aim: The aim of the paper was to make a survey on community pharmacists’ potential in medication adherence support in its connectivity to technical and personnel factors, which underline the capacities of pharmacies in dealing with medication adherence.

Methods: The questionnaire survey was conducted from October to December 2014 and involved 158 pharmacists from 117 Czech (CZ) and 41 Slovak (SK) community pharmacies. The structured questionnaire surveyed both technical and personnel factors, including provision of consultancy services related to medication adherence. Non-adherence risk reduction was evaluated by adopting Morisky Scale modified from the pharmacist’s perspective. Questionnaires outcomes were summarised in contingency tables and analyzed for associations between respective categorical variables using χ2 or exact tests and association coefficients. All results are reported as significant at P≤0.05.

Results: The average score of adherence support (CZ/SK 1.95/1.93) was significantly higher as compared to that of persistence or concordance (P<0.001). Reduction of non-adherence risk reached the score of a medium degree (P=0.73, average 2.29 in CZ and 2.22 in SK). These findings were significantly associated with personnel capacities (provision of consultancy, preference for the use of recommended procedures in CZ (P<0.001), number of years of practice in SK (P=0.029)), while significant association with technical equipment (consultancy room) in the SK (P=0.037).

Conclusion: The pharmaceutical care is developing towards the improvement of medication adherence in both countries - assuming a medium degree of adherence support. Further progress may be observed in strengthening the pharmacists’ personnel capacities, and accelerated mainly using information technologies, i.e. through technical capacities.
Optimization of Operational Parameters of Foam Sizing Process for Cotton Yarns Based on Plackett-Burman Experiment Design
Authors: Zhu Bo , Liu Jianli , Gao Weidong
Published: August 2017

This study was aimed at investigating the process optimization of foam sizing for cotton yarns. In this work, effects of major foam-sizing process factors including size concentration, blowing ratio, stirring speed, pre-wetting temperature, pre-drying temperature, squeezing pressure and drying temperature were studied on the hairiness (more than 3 mm) and abrasion resistance of foam-sized yarns. The combination of Plackett-Burman, steepest ascent path analysis and Box-Behnken design were adopted to optimize the foam-sizing process of cotton yarns. Results revealed that size concentration, blowing ratio and squeezing pressure were significant factors that affected the hairiness and abrasion resistance. Optimum hairiness and abrasion resistance were obtained when the cotton yarns were sized at size concentration of 19.33%, blowing ratio of 4.27 and squeezing pressure of 0.78kN. The theoretical values and the observed values were in reasonably good agreement and the deviation was less than 1%. Verifcation and repeated trial results showed that it has good reproducibility and imparts the foam sizing process of cotton yarns.
Müntz Spectral Methods for the Time-Fractional Diffusion Equation
Authors: Hou Dianming , Hasan Mohammad Tanzil , Xu Chuanju
Published: August 2017

In this paper, we propose and analyze a fractional spectral method for the time-fractional diffusion equation (TFDE).
The main novelty of the method is approximating the solution by using a new class of generalized fractional Jacobi
polynomials (GFJPs), also known as Müntz polynomials.
We construct two efficient schemes using GFJPs for TFDE: one is based on the Galerkin formulation
and the other on the Petrov–Galerkin formulation.
Our theoretical or numerical investigation shows that both schemes are exponentially convergent
for general right-hand side functions, even though the exact solution has very limited regularity (less than

H
1

{H^{1}}

).
More precisely, an error estimate for the Galerkin-based approach is derived to demonstrate its spectral accuracy, which is then confirmed by numerical experiments. The spectral accuracy of the Petrov–Galerkin-based approach is only
verified by numerical tests without theoretical justification.
Implementation details are provided for both schemes, together with
a series of numerical examples to show the efficiency of the proposed methods.
Approximation by q-analogue of modified Jakimovski-Leviatan-Stancu type operators
Authors: Mursaleen Mohammad , Nasiruzzaman Mohammad , Wafi Abdul
Published: August 2017

In this paper, we introduce the q-analogue of the Jakimovski-Leviatan type modified operators introduced by Atakut with the help of the q-Appell polynomials.We obtain some approximation results via the well-known Korovkin’s theorem for these operators.We also study convergence properties by using the modulus of continuity and the rate of convergence of the operators for functions belonging to the Lipschitz class. Moreover,we study the rate of convergence in terms of modulus of continuity of these operators in aweighted space.
FSW between Al alloy and Mg Alloy: the comparative study
Authors: Jagadeesha C. B.
Published: August 2017

It is difficult to fusion weld Al alloy to Mg alloy, so by experimental optimization procedure (EOP) optimum parameters for FSW between Al alloy and Mg alloy were determined and experiment conducted using these parameters resulted in not only sound weld but also highest strength weld for 5 mm thickness of the alloys plates. One can arrive to optimum parameters by following the EOP in case of similar and dissimilar materials FSW, such as Al alloy and Mg alloy FSW. It has observed that tensile sample having least thickness intermetallics (IMs) layer has highest strength compared to sample with larger thickness of intermetallics layer and also it has observed that weld of lesser thickness plates have strength higher than welds of larger thickness plates. It has observed that, Vickers hardness in WN i.e. on the region containing layers of IMs is considerably higher, which leads to emerge of new type of laminated composite materials. It has observed that, it is the least thickness IMs layers in the weld are responsible for higher strength of weld not the ductility of the IMs formed owing to the insertion of intermediate material in the weld. It has found that coefficient of friction is =0.25, in case of bead on plate welding of Mg alloy.
Electrical transport and magnetoresistance of double layered CMR manganites R1.2Sr1.8Mn2O7(R = La, Pr, Sm)
Authors: Reddy Y.S.
Published: August 2017

Polycrystalline bulk samples of double layered (DL) colossal magnetoresistive (CMR) manganites R1.2Sr1.8Mn2O7(R = La, Pr, Sm) were prepared by sol-gel method to study the effect of size of lanthanide ion on their magnetotransport properties. The electrical resistivity of the samples was investigated in the temperature range of 70 K to 300 K at different magnetic fields. The samples LSMO and PSMO show insulator-to-metal transition (IMT) behavior, while SSMO sample exhibits insulating behavior in the entire temperature range with a very large value of resistivity. The insulator-to-metal transition temperature (TIM) decreases from 123 K (LSMO) to 90 K (PSMO) and disappears in SSMO sample. To explain the electrical transport above TIM, the temperature dependent resistivity data (T > TIM) of all the samples were fitted to the equations of different conduction models. The results indicate that the conduction at T > TIMis due to Mott variable range hopping (VRH) mechanism in the LSMO and PSMO samples, while Efros-Shkloskii (ES) type of VRH model dominates the conduction process in the SSMO sample. All the three samples show increasing magnetoresistance (MR) even below TIMand the maximum MR is shown by LSMO (39 % at 75 K, 3 T).
Optical and structural properties of nanostructured copper oxide thin films as solar selective coating prepared by spray pyrolysis method
Authors: Asadi M. , Rozati S.M.
Published: August 2017

Copper (II) oxide thin films were prepared by spray pyrolysis method on soda-lime glass substrates using copper acetate precursor solution. Influence of substrate temperature on structural and optical properties was investigated. Structural analysis of these layers were carried out by X-ray diffraction (XRD). Single phase nature and high crystallinity of CuO nanostructures were observed on XRD patterns. The general appearance of the films was uniform and black in color. FT-IR transmittance spectra confirmed the results from the XRD study. Selective solar absorber coatings of copper oxide (CuO) on stainless steel substrates was prepared by spray pyrolysis method. Effect of deposition temperature on optical properties of thin films was investigated. Optical parameters, absorbance (α) and emittance (α) were evaluated from reflectance data. It can be deduced that the porous structure, such as a light traps, can greatly enhance absorbance, while the composition, thickness and roughness of thin films can greatly influence the emissivity. Single phase nature and high crystallinity of CuO nanostructures were observed by XRD patterns. Solar absorbance of thin films were in the range of 85 % to 92 %.
Selective modification of inner surface of halloysite nanotubes: a review
Authors: Zhang Hailei
Published: August 2017

In this paper, we review the chemical strategies used for the modification of the inner surface of halloysite nanotubes (HNTs). The HNTs are nanotubular materials formed by rolling up the 1:1 aluminosilicate clays, where the composition is similar with kaolin. Owing to many virtues, including the high ratio of length to diameter, large cavity volume, desirable biocompatibility, and low cost, the HNTs have been applied to numerous promising domains. The modification of the outer surface is usually intended to decrease the HNT dispersal in aqueous media. Considering that the selective modification for the inner surface gives excellent prospects for hybrid HNT-based materials, herein, we explore the advances in the selective modification of the inner surface that expanded the applications of the HNTs.
Access to lowland areas for vine conservation: a key determinant of increased utilization of orange-fleshed sweetpotato in Niassa province, Mozambique
Authors: Rakotoarisoa Benjamin E. , Francisco Edgar A. , Jaisse Mario , Naico Abdul , Makunde Godwill , Andrade Maria I. , Muzhingi Tawanda
Published: August 2017

The objective of this study is to evaluate the use of lowland areas for vine conservation to improve the availability and access of planting material during the main planting period and subsequently improve access to Orange Fleshed Sweetpotato (OFSP) roots for consumption and income. The study was implemented in 8 districts in Niassa province in early December 2015, among 271 households (HH), where 77% of these households had children under 5 years and 34% of the respondents were women. These households were selected randomly among households that had received OFSP planting material between 2013 and 2015. Data about vine conservation, use of lowland areas, OFSP consumption and income from OFSP were collected and analyzed using SPSS. Results were compared with the baseline survey results from 2013. Eighty seven percent of households have access to lowland areas. The households using lowland areas for vine conservation increased from 41% in 2013 to 58% in 2015 and the use of small garden plots from 14% to 26%. The households conserving vines in upland fields dropped from 56% in 2013 to 7% in 2015. About 53% of households still planted in June (beyond the main planting season) while 24% continued to plant year around. However, cultivation on small plots dominated from March to December, mainly for vine multiplication. Delvia, Irene and Gloria varieties were mentioned respectively by 43 %, 21 % and 20 % of households as their preferred varieties. All households consumed OFSP roots. However, more than 50% of households consumed OFSP from April to October. Fifty six percent of households sold OFSP roots which generated an average income of 48 USD per household per year. The use of lowland areas for vine conservation has increased and vine management has improved. Consequently, production area has increased by 23%, root yield has increased by more than 100%, from 6.0 t/ ha as average national yield to 15.5 t/ha, average yield for the survey, and the period of consumption from own production has also increased to seven months. Awareness campaigns will continue to promote year round production of OFSP.
Comparing lumbopelvic stabilization exercises and yoga on functional stability and low back pain in young, non-elite, female gymnasts
Authors: Hecimovich Mark , Pomije M. , Harbaugh A.
Published: August 2017

Background: It is beneficial for gymnasts to train key lumbopelvic musculature to decrease or prevent low back injury. This study compares lumbopelvic exercises and yoga on lumbar muscle endurance, lumbopelvic stabilization, abdominal strength and balance in adolescent female gymnasts and the effect on low back pain. Material/Methods: 13 participants were randomly allocated to a lumbo-pelvic or yoga group intervention and performed specific exercises for 6 weeks. Biering-Sorensen Test, Lumbopelvic Control Test, Side Bridge Test, and Star Excursion Balance Test were conducted on the participants before and after the 6-week intervention and low back pain logbooks were completed. Results: The Biering-Sorensen Test was significantly greater results for the lumbopelvic group compared to the yoga group. Both groups had significant changes over time with the Lumbopelvic Control Test but no group difference. Both groups had significant improvement with the Side Bridge with the yoga group benefitting more on the left. Out of the six fully completed logbooks, the yoga group showed less occurrence of low back pain compared to the lumbopelvic group. Conclusions: Yoga and lumbopelvic stabilization exercises are equally effective in developing lumbar muscle endurance, lateral stability and front-on stability for young non-elite gymnasts. This is important as they are under-represented in research but overrepresented in participation. This study sets the basis for further research on the incidence of low back pain in young gymnasts and the effects of age-appropriate exercises as a preventative matter.
Comparisons in the Recovery Response From Resistance Exercise Between Young and Middle-Aged Men
Authors: Gordon Joseph A. , Hoffman Jay R. , Arroyo Eliott , Varanoske Alyssa N. , Coker Nicholas A. , Gepner Yftach , Wells Adam J. , Stout Jeffrey R. , Fukuda David H.
Published: August 2017

Gordon, JA III, Hoffman, JR, Arroyo, E, Varanoske, AN, Coker, NA, Gepner, Y, Wells, AJ, Stout, JR, and Fukuda, DH. Comparisons in the recovery response from resistance exercise between young and middle-aged men. J Strength Cond Res 31(12): 3454–3462, 2017—The purpose of this study was to compare the effects of a bout of high-volume isokinetic resistance exercise protocol (HVP) on lower-body strength and markers of inflammation and muscle damage during recovery between young and middle-aged adult men. Nineteen recreationally trained men were classified as either a young adult (YA: 21.8 ± 2.0 years; 90.7 ± 11.6 kg) or a middle-aged adult (MA: 47.0 ± 4.4 years; 96.0 ± 21.5 kg) group. The HVP consisted of 8 sets of 10 repetitions, with 1 minute of rest between each set, performed on an isokinetic dynamometer at 60°·s−1. Maximal voluntary isometric contractions and isokinetic peak torque (PKT) and average torque (AVGT) (measured at 240° and 60°·s−1, respectively) were assessed at baseline (BL), immediately post (IP), 120 minutes, 24, and 48 hours after HVP. Blood was obtained at BL, IP, 30, 60, 120 minute, 24, and 48 hours after HVP to assess muscle damage and inflammation. All performance data were analyzed using repeated measures analysis of covariance, whereas all inflammatory and muscle damage markers were analyzed using a 2-way (time × group) repeated measures analysis of variance. Results revealed no between-group differences for PKT, AVGT, or rate of torque development at 200 ms (RTD200). No between-group differences in myoglobin, creatine kinase, C-reactive protein, or interleukin-6 were observed. Although BL differences in muscle performance were observed between YA and MA, no between-group differences were noted in performance recovery measures from high-volume isokinetic exercise in recreationally trained men. These results also indicate that the inflammatory and muscle damage response from high-volume isokinetic exercise is similar between recreationally trained, young, and middle-aged adult men.
Roles of increased glycaemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass
Authors: Tharakan George , Behary Preeshila , Wewer Albrechtsen Nicolai J , Chahal Harvinder , Kenkre Julia , Miras Alexander D , Ahmed Ahmed R , Holst Jens J , Bloom Stephen R , Tan Tricia
Published: August 2017

Objective

Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment for diabetes and obesity. An increasingly recognized and highly disabling complication of RYGB is postprandial hypoglycaemia (PPH). The pathophysiology of PPH remains unclear with multiple mechanisms suggested including nesidioblastosis, altered insulin clearance and increased glucagon-like peptide-1 (GLP-1) secretion. Whilst many PPH patients respond to dietary modification, some have severely disabling symptoms. Multiple treatments are proposed, including dietary modification, GLP-1 antagonism, GLP-1 analogues and even surgical reversal, with none showing a more decided advantage over the others. A greater understanding of the pathophysiology of PPH could guide the development of new therapeutic strategies.

Methods

We studied a cohort of PPH patients at the Imperial Weight Center. We performed continuous glucose monitoring to characterize their altered glycaemic variability. We also performed a mixed meal test (MMT) and measured gut hormone concentrations.

Results

We found increased glycaemic variability in our cohort of PPH patients, specifically a higher mean amplitude glucose excursion (MAGE) score of 4.9. We observed significantly greater and earlier increases in insulin, GLP-1 and glucagon in patients who had hypoglycaemia in response to an MMT (MMT Hypo) relative to those that did not (MMT Non-Hypo). No significant differences in oxyntomodulin, GIP or peptide YY secretion were seen between these two groups.

Conclusion

An early peak in GLP-1 and glucagon may together trigger an exaggerated insulinotropic response to eating and consequent hypoglycaemia in patients with PPH.
THERAPY OF ENDOCRINE DISEASE: T4 + T3 combination therapy: is there a true effect?
Authors: Wiersinga Wilmar M
Published: August 2017

About 5%–10% of hypothyroid patients on T4 replacement therapy have persistent symptoms, despite normal TSH levels. It was hoped that T4 + T3 combination therapy might provide better outcomes, but that was not observed according to a meta-analysis of 11 randomized clinical trials comparing T4 monotherapy with T4 + T3 combination therapy. However, the issue is still subject of much research because normal thyroid function tests in serum may not necessarily indicate an euthyroid state in all peripheral tissues. This review evaluates recent developments in the field of T4 + T3 combination therapy. T4 monotherapy is associated with higher serum FT4 levels than in healthy subjects, and subnormal serum FT3 and FT3/FT4 ratios are observed in about 15% and 30% respectively. T4 + T3 combination therapy may mimic more closely thyroid function tests of healthy subjects, but it has not been demonstrated that relatively low serum FT3 or FT3/FT4 ratios are linked to persistent symptoms. One study reports polymorphism Thr92Ala in DIO2 is related to lower serum FT3 levels after thyroidectomy, and that the D2-Ala mutant reduces T4 to T3 conversion in cell cultures. Peripheral tissue function tests such as serum cholesterol reflect thyroid hormone action in target tissues. Using such biochemical markers, patients who had a normal serum TSH during postoperative T4 monotherapy, were mildly hypothyroid, whereas those with a TSH 0.03–≤0.3 mU/L were closest to euthyroidism. Peripheral tissue function tests suggest euthyroidism more often in patients randomized to T4 + T3 rather than that to T4. Preference for T4 + T3 combination over T4 monotherapy was dose-dependently related to the presence of two polymorphisms in MCT10 and DIO2 in one small study. It is not known if persistent symptoms during T4 monotherapy disappear by switching to T4 + T3 combination therapy. The number of patients on T4 + T3 therapy has multiplied in the last decade, likely induced by indiscriminate statements on the internet. Patients are sometimes not just asking but rather demanding this treatment modality. It creates tensions between patients and physicians. Only continued research will answer the question whether or not T4 + T3 combination therapy has true benefits in some patients.
Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance
Authors: Wada Tsutomu , Ishikawa Akari , Watanabe Eri , Nakamura Yuto , Aruga Yusuke , Hasegawa Hayate , Onogi Yasuhiro , Honda Hiroe , Nagai Yoshinori , Takatsu Kiyoshi , Ishii Yoko , Sasahara Masakiyo , Koya Daisuke , Tsuneki Hiroshi , Sasaoka Toshiyasu
Published: August 2017

Obesity-associated activation of the renin-angiotensin-aldosterone system is implicated in the pathogenesis of insulin resistance; however, influences of mineralocorticoid receptor (MR) inhibition remain unclear. Therefore, we aimed to clarify the anti-inflammatory mechanisms of MR inhibition using eplerenone, a selective MR antagonist, in C57BL/6 mice fed a high-fat diet (HFD) for 12 weeks. Eplerenone prevented excessive body weight gain and fat accumulation, ameliorated glucose intolerance and insulin resistance and enhanced energy metabolism. In the epididymal white adipose tissue (eWAT), eplerenone prevented obesity-induced accumulation of F4/80+CD11c+CD206−-M1-adipose tissue macrophage (ATM) and reduction of F4/80+CD11c−CD206+-M2-ATM. Interestingly, M1-macrophage exhibited lower expression levels of MR, compared with M2-macrophage, in the ATM of eWAT and in vitro-polarized bone marrow-derived macrophages (BMDM). Importantly, eplerenone and MR knockdown attenuated the increase in the expression levels of proIl1b, Il6 and Tnfa, in the eWAT and liver of HFD-fed mice and LPS-stimulated BMDM. Moreover, eplerenone suppressed IL1b secretion from eWAT of HFD-fed mice. To reveal the anti-inflammatory mechanism, we investigated the involvement of NLRP3-inflammasome activation, a key process of IL1b overproduction. Eplerenone suppressed the expression of the inflammasome components, Nlrp3 and Caspase1, in the eWAT and liver. Concerning the second triggering factors, ROS production and ATP- and nigericin-induced IL1b secretion were suppressed by eplerenone in the LPS-primed BMDM. These results indicate that eplerenone inhibited both the priming and triggering signals that promote NLRP3-inflammasome activation. Therefore, we consider MR to be a crucial target to prevent metabolic disorders by suppressing inflammasome-mediated chronic inflammation in the adipose tissue and liver under obese conditions.
Role of FSH glycan structure in the regulation of Sertoli cell inhibin production
Authors: Andreone Luz , Ambao Verónica , Pellizzari Eliana H , Loreti Nazareth , Cigorraga Selva B , Campo Stella
Published: August 2017

Variations in follicle-stimulating hormone (FSH) carbohydrate composition and structure are associated with important structural and functional changes in Sertoli cells (SCs) during sexual maturation. The aim of the present study was to investigate the impact of FSH oligosaccharide structure and its interaction with gonadal factors on the regulation of monomeric and dimeric inhibin production at different maturation stages of the SC. Recombinant human FSH (rhFSH) glycosylation variants were isolated according to their sialylation degree (AC and BA) and complexity of oligosaccharides (CO and HY). Native rhFSH stimulated inhibin α-subunit (Pro-αC) but did not show any effect on inhibin B (INHB) production in immature SCs isolated from 8-day-old rats. Activin A stimulated INHB and had a synergistic effect on FSH to stimulate Pro-αC. The less acidic/sialylated rhFSH charge analogues, BA, were the only charge analogue mix that stimulated INHB as well as the most potentstimulusfor Pro-αC production. Native rhFSH stimulated both Pro-αC and INHB in SCs at a more advanced maturation stage, isolated from 20-day-old rats. In these cells, all rhFSH glycosylation variants increased INHB and Pro-αC production, even in the presence of growth factors. The BA preparation exerted a more marked stimulatory effect on INHB and Pro-αC than the AC. Glycoforms bearing high mannose and hybrid-type oligosaccharides, HY, stimulated INHB and Pro-αC more effectively than those bearing complex oligosaccharides, CO, even in the presence of gonadal growth factors. These findings demonstrate the modulatory effect of FSH oligosaccharide structure on the regulation of inhibin production in the male gonad.
Is There a Future for Remote Cardiac Implantable Electronic Device Management?
Authors: Burri Haran ,   Cardiology Department, University Hospital of Geneva, Geneva, Switzerland
Published: August 2017

In the era of communication technology, remote monitoring has been a paradigm shift in the way patients with cardiac implantable electronic devices are managed. It has been endorsed by scientific societies and is being increasingly adopted in the clinical setting. Despite the various advantages associated with this strategy, data on improved clinical outcome are still sparse. The recently published study on the remote management of heart failure using implanted devices and formalised follow-up procedures, which turned out to be negative, has cast doubt on whether remote monitoring should still be used. This article provides a critical appraisal of the study, and discusses the issue of remote data management.
High performance control of a three-phase PWM rectifier using odd harmonic high order repetitive control
Authors: Ramos Fuentes German Andrés , Cifuentes Quintero Jenny Alexandra , Melo Lagos Iván Dario
Published: August 2017

El objetivo de control en rectificadores de potencia trifásicos se basa en generar corrientes de entrada sinusoidales y regular el voltaje de salida DC. Aunque el Control Repetitivo y Resonante son enfoques de control que han presentado excelentes resultados, su principal desventaja se basa en la pérdida considerable de desempeño cuando la frecuencia de la red se desvía de su valor nominal. En este artículo, se presenta el uso de un Controlador Repetitivo Impar de Alto Orden para controlar los lazos de corrientes de un rectificador trifásico con un desempeño considerablemente superior a otras alternativas tradicionalmente implementadas en este campo. Este controlador permite el rechazo de los armónicos impares introducidos en el sistema, lo que mantiene una complejidad computacional similar a la obtenida con los controladores repetitivos convencionales con la ventaja de incrementar la robustez cuando la frecuencia de la señal varíe. Las simulaciones y los resultados experimentales muestran un alto desempeño aún cuando se presenten desviaciones de la frecuencia de la red respecto a su valor nominal.
Implementación en FPGA del algoritmo AES-128 en modos de operación no realimentados
Authors: Guzmán Ian Carlo , Nieto Rubén Darío , Bernal Álvaro
Published: August 2017

En este artículo, presentamos una implementación hardware segmentada del algoritmo AES-128 en modos de operación no realimentados (ECB, CTR). La arquitectura fue implementada en la FPGA Virtex 5 de Xilinx. Dos modos de operación (ECB,CTR) para encriptación y desencriptación de acuerdo a uso de recursos, rendimiento y seguridad fueron comparados. Una frecuencia de reloj de 272.59Mhz para el proceso de encriptación ECB fue obtenida, la cual es equivalente a un rendimiento de 34.89 Gb/s. Además, una frecuencia de reloj de 199.48Mhz para el proceso de desencriptación, equivalente a un rendimiento de 25.5Gb/s fue obtenido. En el modo CTR, una frecuencia de reloj de 272.59Mhz. equivalente a un rendimiento de 34.89Gb/s fue obtenido.
O diálogo entre o Anjo e a Virgem: análise do processo comunicativo da perícope de Lc 1,26-38
Authors: Paganotto Diones Rafael
Published: August 2017

Lc 1,26-38 é um dos principais textos mariológicos, tradicionalmente conhecido como o anúncio do anjo Gabriel à virgem Maria. A perícope já foi analisada sob vários pontos de vista com o uso de distintas abordagens diacrônicas e sincrônicas. O presente artigo valorizará o texto no seu estado final, ou seja, avaliará os vários elementos presentes no diálogo entre o anjo e a virgem em função do processo comunicativo que autor propõe ao leitor. De fato, o próprio texto já contém os elementos necessários para compreender a sua proposta comunicativa, visto que o anjo propõe algo à virgem e também ao leitor, logo o diálogo não é fechado em si, mas provoca uma reação no leitor.
Movimentos sociais e seus efeitos nas políticas públicas: balanço do debate e proposições analíticas
Authors: Carlos Euzeneia , Dowbor Monika , Albuquerque Maria do Carmo Alves
Published: August 2017

Como podemos estudar os efeitos de movimentos sociais na produção de políticas públicas? Esta pergunta se mostra relevante, pois no Brasil pós-transição muitos movimentos sociais se engajaram na política institucionalizada com esta finalidade, mas é também desafiadora na medida em que as abordagens teórico-analíticas não oferecem ainda proposições consolidadas e têm privilegiado protestos como a forma de ação de movimentos. O artigo mapeia e discute criticamente os modelos analíticos que se propõem a explicar os efeitos políticos de movimentos sociais, com base na literatura voltada para este ator coletivo. Diante destes desafios, apresenta proposições acerca da complementaridade entre o modelo de mediação política e a abordagem de polis. Essa última, oferece categorias mais robustas para analisar as dimensões do Estado e os processos de mútua constituição entre atores societários e instituições políticas, através do conceito de encaixe institucional.
Comorbid pathological gambling, mental health, and substance use disorders: Health-care services provision by clinician specialty
Authors: Rodriguez-Monguio Rosa , Errea Maria , Volberg Rachel
Published: August 2017

Background and aims

Pathological gambling (PG) is an impulse control disorder. This study assessed the burden of co-occurring behavioral addictions and mental health disorders in treatment-seeking patients and estimated the likelihood of receiving care for these disorders by clinician specialty.

Methods

Study data were derived from the Massachusetts All-Payer Claims Database, a representative database, for the period 2009–2013. The sample included commercially insured adult residents of Massachusetts. Univariate and multivariate logistic regressions were used to estimate the likelihood of provision of care by clinician specialty adjusting for patient’s demographic characteristics and level of care. Bonferroni correction was applied to adjust for multiple testing.

Results

The study sample included 869 patients. Treatment-seeking patients who had a diagnosis of PG were mostly males (71%), aged 45–54 years (26.7%) and enrolled in a health maintenance organization (47%). The most prevalent co-occurring disorders among patients with PG as principal diagnosis were anxiety disorders (28%), mood disorders (26%), and substance use disorders (18%). PG was associated with a more than twofold likelihood of receiving care from social workers and psychologists (p < .05). Depressive disorders were associated with a three times greater likelihood of receiving care from primary care physicians (PCPs) (p < .05). Having three and four or more diagnosis was associated with a greater likelihood of receiving care from PCPs.

Discussion and conclusions

Psychiatric and substance use disorders are prevalent among treatment-seeking pathological gamblers. The likelihood of receiving care from specialty clinicians significantly varies by clinical diagnosis and patient clinical complexity.
COOPERATIVAS AGROPECUÁRIAS E O DESAFIO DA SUCESSÃO NA AGRICULTURA FAMILIAR
Authors: Drebes Laila Mayara , Spanevello Rosani Marisa
Published: August 2017

O estudo visa analisar as contribuições das cooperativas agropecuárias sobre a sucessão nos estabelecimentos agropecuários familiares. Foi conduzido como estudo de casos amostrados através de critérios institucionais e geográficos, envolvendo oito cooperativas. Os dados foram coletados com entrevistas junto aos dirigentes e jovens rurais vinculados com as organizações. Também foram utilizadas fontes documentais. Esses dados foram submetidos à análise de conteúdo. Notou-se interesse das cooperativas agropecuárias sobre a sucessão, com o desenvolvimento de ações voltadas a condicionantes socioeconômicas significantes aos jovens rurais. Embora os resultados alcançados sejam tímidos, a contribuição das cooperativas agropecuárias mostrou-se relevante à sucessão na agricultura familiar.
PROCESSO DE ENSINO-APRENDIZAGEM DOS CONCEITOS DE ÁCIDOS E BASES COM A INSERÇÃO DA EXPERIMENTAÇÃO UTILIZANDO A TEMÁTICA SABÃO ECOLÓGICO
Authors: Dantas Filho Francisco Ferreira , Costa André Santos da , Silva Gilberlândio nunes da
Published: August 2017

Atualmente as práticas experimentais no ensino de Química se tornaram uma ferramenta essencial para o processo de ensino e aprendizagem. Neste caso, analiza- se que é indispensável a existência de um laboratório nas escolas, para a realização de experimentos, o que não impossibilita a prática destes, uma vez que, é possível trabalhar com outros espaços dentre eles, a sala de aula. A Química pode ser trabalhada com materiais alternativos que estão presentes no cotidiano que são de baixo custo. Neste contexto, o estudo aborda a temática sabão ecológico, obtido com óleo de frituras nas aulas de Química seguindo uma proposta didática implementada numa escola pública de ensino médio do Município de Arara- PB, trabalhando os conceitos de funções orgânicas. As atividades desenvolvidas incluíram exposição de conceitos, aplicação de questionários, atividade experimental, além de resolução de questões de vestibulares/ ENEM referentes ao assunto. Os resultados evidenciaram que a temática sabão ecológico contribuiu para melhor compreensão de conceitos químicos abordados por parte dos alunos, inclusive, desmistificou com base no conhecimento científico, algumas concepções em relação à formação de espuma, à presença de bases na fabricação do sabão e a influência do pH sobre as mãos. Destarte, o tema favoreceu resgatar a cultura de outrora do aproveitamento de gorduras animais e cinzas de fogão a lenha para a produção do sabão que era utilizado no uso doméstico pelos nordestinos para lacrar silos de armazenamento de cereais, contribuído assim, para a conscientização ambiental.Palavras-chave: Sabão ecológico; Proposta didática; Ensino de Química.