bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Modul Parenting dalam Pembelajaran Membaca Permulaan di Kelas I Sekolah Dasar
Authors: Lestari Hesti , Wahyudi Wahyudi , Suhartono Suhartono
Published: February 2023

Penelitian ini bertujuan untuk (1) mengidentifikasi karakteristik modul parenting yang dibutuhkan orang tua, (2) mengembangkan produk berupa modul parenting dalam pembelajaran membaca permulaan, dan (3) menganalisis kelayakan produk. Jenis penelitian yang digunakan adalah Research and Development (R&D) dengan model pengembangan ADDIE melalui tahap analisis, perancangan, pengembangan, implementasi, dan evaluasi. Uji validasi dilakukan oleh validator ahli materi, ahli media, dan ahli bahasa. Uji coba produk dilaksanakan di SDN 1 Jogomertan dan SDN 2 Jogomertan dengan subjek orang tua dan guru kelas I SD. Jenis data yang digunakan adalah data kuantitatif dan kualitatif dengan instrumen pengumpulan data berupa observasi, wawancara, dan angket. Teknik analisis data yang digunakan yaitu analisis data deskriptif kuantitatif dan kualitatif. Hasil penelitian ini menunjukkan bahwa modul parenting dalam pembelajaran membaca permulaan di kelas I SD yang diproses secara terstruktur dan terarah yang sudah sesuai kebutuhan dan layak digunakan sebagai buku penunjang orang tua dalam mempelajari ilmu parenting.
The Role of Micro Waqf Bank through Joint Liability Qard Financing in MSME Empowerment
Authors: Hadi Solikhul , Raunaqa Yoga
Published: February 2023

This study aims to describe: (1) how the implementation of the practice in empowering MSMEs at the Assa Berkah Sejahtera Kudus Micro Waqf Bank, (2) how the results of qardh financing and the results of the practice of joint responsibility financing in empowering MSMEs by the Assa Berkah Sejahtera Kudus Micro Waqf Bank, and (3) the inhibiting factors for financing the practice of joint responsibility at the Assa Berkah Sejahtera Kudus Micro Waqf Bank and what are the solutions to overcome these inhibiting factors. This research is a type of field research (field research). The approach used by researchers in this study is qualitative research. Sources of data in this study are primary data and secondary data. Primary data sources are managers, as well as several customers of the Assa Berkah Sejahtera Micro Waqf Bank. Meanwhile, secondary data sources are library books and documentation. Based on the results of the research obtained, this study shows that: (1) The implementation of the practice of joint responsibility is going well using a qardh contract and has succeeded in being a solution for customers who have difficulty paying the installments for the repayment of business capital. (2) The results of qardh financing are an increase in business and an increase in income, while the results of the practice of joint responsibility for empowering MSMEs are creating a sense of kinship and responsibility among members (3) The inhibiting factor is the lack of concern and a sense of responsibility with several prospective customers who are still selfish alone. The solution to overcome the inhibiting factors is to hold mandatory group training for five consecutive days with one of the materials, namely the practice of joint responsibility financing.
Customer Interest in Using BSI e-Banking During the Covid-19 Pandemic: Relationships Between Benefit Perceptions, Trust, and Personal Attitude
Authors: Dewi Siska , Hidayati Athi' , Qomar Moh Nurul
Published: February 2023

The phenomenon of the COVID-19 pandemic motivates this research, as it shifts people's lifestyles to a cashless society, resulting in an increase in e-banking growth during the pandemic period. The goal of this study is to see how perceived benefits, trust, and personal attitude affect interest in using BSI e-banking during the COVID-19 pandemic. This research method employs quantitative methods as well as sampling techniques with secondary objectives. This study was conducted in Kudus city, with respondents being BSI e-banking users. The data was gathered through the use of a questionnaire, which was distributed to 96 respondents. The findings revealed that during the COVID-19 pandemic, the benefit perceptions, trust, and personal attitude all had a positive and significant effect on interest in using e-banking. Because the COVID-19 pandemic has not yet ended, e-banking will continue in the future. So, service providers like BSI must increase these deciding factors to encourage long-term use. They can do this by making users happier with the benefits of the product and by showing high integrity to build trust. This will give users a good attitude that makes them want to keep using the product
Testing The Effect of Islamic Financial Inclusion, Infrastructural Quality on Economic Growth in Nigeria: New Insight From Bootstrap and Non-Linear ARDL
Authors: Sani Ibrahim Saifullahi , Sanusi Hussaina
Published: February 2023

Inclusive growth can hardly be achieved without improvement in the inclusive finance that would enable the vulnerable households to become key economic players. While efforts are now shifted towards the Islamic financial inclusion based on the realization of weakness of traditional financial inclusivity, the impact of Islamic financial inclusion particularly, its pathways of bridging infrastructural gaps and growth drive have been partially explored. This study examines the effect of Islamic financial inclusion, infrastructural quality on economic growth in Nigeria. The study uses monthly data covering from 2017 until 2020 which was analyzed via a newly developed Bootstrap Autoregressive Distributive Lag. The results reveal a number of findings. First, the result of bootstrap autoregressive distributed lag demonstrates that there is strong co-movement between economic growth, Islamic financial inclusion, Sukuk and infrastructural quality. This finding points to the existence of a strong positive relationship between Islamic financial inclusion, infrastructural quality and economic growth in Nigeria. Second, results from nonlinear models have revealed that Islamic financial inclusion and Sukuk have asymmetric effects on economic growth. This asymmetric pattern reinforces the claim that Islamic financial inclusion can play a dedicated role in ameliorating economic downturn. Third, the results of nonlinear causality reveal strong bidirectional causality Islamic financial inclusion, economic growth and Sukuk. In this sense, inclusive Islamic finance could play a dedicated role to help countries in overcoming economic recession.
Evaluation of Body Weight, Morphometry, and Physiology Status of Etawah Crossbred Doeling on Two Different Farms Management
Authors: Ma'rufah Nur Laili , Murti Tridjoko Wisnu , Widyobroto Budi Prasetyo , Astuti Sulvia Dwi
Published: February 2023

This study aimed to evaluate the body weight (BW), morphometry, and physiological status of Etawah Crossbred Doeling (ECD) under different farms management. This study was performed in two farms, Garage (Tlogoadi village, Mlati subdistrict) and Bumiku Hijau (Margomulyo village, Seyegan subdistrict), both located in Yogyakarta and each farm used 6 ECD as the replications (12 animals in total). Parameters of the study consist of body weight (BW), morphometry (chest girth, hip height, body length, chest depth, ear length, ear width, and withers height), physiological status (respiration, pulse, and rectal temperature). The parameter was measured weekly for four consecutive weeks of observation. The results showed that the difference in farm management between Garage and Bumiku Hijau influenced on the BW, morphometry, and physiological status of ECD. The study showed that the BW and all morphometry from the Garage farm was higher than Bumiku Hijau farm (P<0.05). However, the physiological status (except for rectal temperature) from Garage farm was lower than Bumiku Hijau farm (P<0.05). It can be concluded that Garage farm implemented better good farming practices compared to Bumiku Hijau farm.
Factors Affecting Buffaloes’ Farmers Commitment toward Accessibility of Resources in Pemalang District, Central Java, Indonesia
Authors: Muatip Krismiwati , Purwaningsih Hermin , Enstein Alief , Djatmiko Oentoeng Edy , Mastuti Sri , Hidayat Nunung Noor , Widiyanti Rahayu , Wakhidati Yusmi Nur , Safitri Lis , Cahyo Danang Nur
Published: February 2023

This study was aimed to measure the farmers' commitment, accessibility of resources (information, capital, and assistance), and the correlation between those variables. The research method used in the current study was the survey method. The location was purposively selected in Pemalang Regency, the regency with the largest buffalo population in Central Java Province. Three subdistricts (20%) with formal and informal farmers' groups were selected, and there were Taman, Pemalang, and Belik subdistricts. One Village was selected for each subdistrict. Respondents for informal groups were taken by census method. Respondents in formal groups were taken by random sampling, and the number of respondents followed the number of informal groups. There were 136 farmers selected as respondents. (69 from each formal and informal groups). The data were analyzed using the descriptive and rank Spearman correlation methods. The results showed that the farmers' commitment of formal group and informal group members was in the moderate and low categories respectively based on the percentage score interval scaling method. Resources accessibility of formal and informal members of the farmers' group was in the low to moderate category, but the member of formal groups was slightly better. There was a strong correlation between the accessibility of resources with the commitment in the formal groups, whereas in the informal groups there was a moderate to strong correlation between the accessibility of resources with the commitment of buffalo farmers. Based on the conclusion, this study recommend that the government should assist the informal farmer group to establish formal group with the result that would increase farmers accessibility toward  information, support, and capital. That condition would increase farmers commitment to continue their buffalo farm business in Pemalang Regency.
Utilization of Different Concentration Sugarcane Molasses to the Quality of Goat Feces-Chicken Excreta-Coconut Husk Organic Liquid Fertilizer
Authors: Priyadi Dwi Ahmad , Toni Sefri , Istanti Ari
Published: February 2023

Indonesia is an agricultural country that certainly has the potential for agricultural waste and by-products. Some of those in Indonesia are livestock manure, coconut husk, and sugarcane molasses. Utilization of this waste is limited, which is causing various environmental problems such as environmental pollution. The study is aimed to determine the quality of organic liquid fertilizer made by raw material from goat feces-chicken excreta-coconut husk with various sugarcane molasses concentrations (P0= 0%; P1= 5%; P3= 15%; P4= 20%; P5= 25%). The fermentation was carried out anaerobically for 21 days. The parameters of temperature, pH, organoleptic (color and odor), levels of C-organic, nitrogen (N) total, phosphorus (P) total, potassium (K) total, and biological tests were observed. Biological tests were conducted in the growth of mung bean (Vigna radiata) and spinach (Amaranthus tricolor). Data were analyzed using one-way ANOVA. Variations in the addition of molasses sugarcane did not affect the liquid fertilizer's temperature and pH during fermentation. However, the treatments had positive effect on organoleptic test, C-organic, N total, P total, K total, and biological tests. The addition of 15% sugarcane molasses (P3) showed a dominating performance toward most of the parameters tested. The P3 treatment produced liquid fertilizer with a pleasant smell, and the contents of C-organic, total N, total P, and total K were 2.12%, 0.25%, 0.13%, and 0.13%,  respectively. and produce spinach as a biological test with plant height, number of leaves, leaf width, stem diameter, and root length were 21.82 cm, 6.66 sheets, 3.59 cm, 4.09 mm, and 14.67 cm, respectively.
Polymorphism and Association of the Novel KCTD2 Gene with Flavor and Odor in Indonesian Local Sheeps
Authors: Herpina Herpina , Listyarini Kasita , Sumantri Cece , Roosita Katrin , Gunawan Asep
Published: February 2023

A candidate marker that influences the flavor and odor of Indonesian sheep that is the Potassium Channel Tetramerization Domain Containing 2 (KCTD2) gene. This study aims to examine the polymorphism and association between the KCTD2 gene and lamb flavor and odor in Indonesian local sheeps. This study used DNA taken from the longissimus dorsi (LD) muscle of 100 rams including 75 Javanese Thin-Tail sheep (JTTS), 10 Javanese Fat-Tail Sheep (JFTS), and 15 Jonggol Sheep (JS), with ranged in weight from 20 to 35 kg and were 10 to 12 months old. The PCR-RFLP technique and GLM test analysis were used to identify polymorphisms and association of KCTD2 gene. The restriction enzyme BafI digests the PCR-RFLP product of the KCTD2 gene. The results showed that the KCTD2 gene was polymorphic (CC and CT). KCTD2 gene analysis showed a significant (P<0.05) association with 3-Methylphenol (MP). This research provide information regarding the role of the KCTD2 gene in lamb flavor and odor, especially in 3-Methylphenol (MP) compounds, and explain KCTD2 as a functional gene in the selection of premium sheep with low flavor and odor in lamb meat.
Information Culture - The Priority Direction of Developing Information-Analytical Competence in Future History Teachers
Authors: Siddikov Ilyasjon
Published: February 2023

In everyday international relations, concepts such as "informational threat", "informational culture", "informational attack" are becoming widely used, increasing the urgency of the need to develop specific measures for the formation of informational culture in future personnel. The article analyzes opinions on the formation of informational culture in future history teachers in teaching history, telling historical truths, cleaning history from lies and fabrications.
Extensive Central Nervous System Lymphoma Detected at the Time of Diagnosis of Chronic Lymphocytic Leukemia - An Isolated Central Nervous System Richter’s Syndrome: A Case Report
Authors: Kim Inkyeong , Ryu Young-Joon
Published: February 2023

When a central nervous system (CNS) lesion is found in patients with chronic lymphocytic leukemia (CLL), the diagnostic possibilities include CNS involvement of CLL, transformation to a large B-cell lymphoma (Richter’s syndrome [RS]), or the coincidental presence of another tumorous or non-tumorous disease. CNS RS commonly occurs in preexisting CLL with other nodal/extra-nodal involvement, but it is extremely rare to find isolated CNS RS concurrently with the initial diagnosis of CLL. A 73-year-old woman presented with a headache and findings from another hospital of an elevated white blood cell count and intraventricular masses. A peripheral blood smear and a bone marrow biopsy revealed CLL. Brain magnetic resonance imaging with gadolinium enhancement showed a suprasellar mass and a pineal mass within the third ventricle, as well as extensive leptomeningeal enhancement. Whole-body fluorodeoxyglucose proton emission tomography-computed tomography showed no hot uptake except for the brain lesions. Cerebrospinal fluid cytology showed small atypical lymphocytes suggestive of CLL involvement. However, an endoscopic biopsy of the third-ventricle mass demonstrated diffuse large B-cell lymphoma. After 3 months of systemic high-dose methotrexate, all preexisting lesions disappeared, but new hemorrhagic masses were found in the right lateral ventricle and the fourth ventricle. The patient received palliative cranial radiotherapy but died 6 months after the initial diagnosis. Accurate CNS tissue diagnosis and appropriate treatment are critical.
A novel technique for encoding images using Chen model and computer-generated holograms
Authors: Ali Nabaa , Jamal Raied K.
Published: February 2023

In this work, computer-generated hologram technology was used to encode information and link it to one of the chaotic system models (Chen), using the Matlab program. The results showed that the information (images) can be easily identified using computer-generated holograms through the process of computer holographic reconstruction of the images to be encrypted, and this process is undesirable in secure communications, But when linking with the chaotic Chen system through several mathematical operations including addition, multiplication and division, the resulting holograms of the image to be encrypted and the hologram of the Chen system, where the results showed complete encryption of the images to be encrypted and the disappearance of their features using the division process.
The Demand for Healthy Aging Services among Young and Middle-Aged People in Zhuang inhabited Regions and its influencing factors: A cross-sectional study
Authors: Ouyang Ziyao , Fan Dengjing , Su Lin , Li Gaopeng , Pan Xiao , Chen Lin , Pan Yanfei , Li Caili , Tao Pinyue , Huang Huiqiao
Published: February 2023

Background
Although policy actions and strategic efforts have recognized the importance of healthy aging services for Chinese older adults, supply and utilization remains low.
Aims
To analyze the demand and influencing factors for healthy aging services among young and middle-aged people in the Zhuang-inhabited area in Guangxi province.
Methods
A cross-sectional survey was conducted with 1,731 participants in Guangxi, which comprised demographic and healthy aging services demand questionnaires.
Results
The top three demands were legal aid, pension fund, and pension environment. Age, ethnicity, and occupation were the common influencing factors of healthy aging services for young and middle-aged people. Furthermore, various factors affected each dimension of demand, showing a trend of individualization and diversification.
Conclusion
It is urgent to establish a prediction model of healthy aging demand for young and middle-aged people. Moreover, the government should implement activities to reform healthy aging services and the distinct service needs in Guangxi.
Surgical Outcomes of Standardized Endoscopical Deep Medial Orbital Decompression in Dysthyroid Optic Neuropathy
Authors: Li Cheng , Gao Yang , Zhang Zhihui , Lv Xi , Bao Yuekun , Ma Yujun , Chen Rongxin , Cheng Chao , Li Jinmiao , Liu Yaoming , Jin Ling , Luo Guangwei , Shi Jianbo , Lu Rong
Published: February 2023

Objectives: To standardize the endoscopic deep medial orbital decompression surgery for better relief of optic nerve compression in dysthyroid optic neuropathy (DON).
Methods: A total of 128 eyes from patients received the standardized endoscopic deep medial orbital decompression surgery were recruited in this study. The efficacy of the procedure was assessed at a one-month follow-up by the best-corrected visual acuity (VA), visual field (VF), and visual evoked potential (VEP). Clinical data were collected to explore the factors that affected visual recovery. Oxygen saturation of retinal blood vessels, retinal thickness, and vessel density were measured to demonstrate the potential recovery mechanisms.
Results: After surgery, the ratio of extraocular muscle volume in the orbital apex to orbital apex volume significantly decreased from 44.32 ± 22.31% to 36.82 ± 12.02% (P < 0.001). 96.87% of eyes’ final VA improved, average VA improved from 0.93 ± 0.73 to 0.50 ± 0.60 at 1 week (P < 0.001) and 0.40 ± 0.53 at 1 month (P < 0.001). Postoperatively VF and VEP also improved, the oxygen saturation of retinal arteries increased, and the retinal thickness was reduced. Preoperative VA, visual impairment duration, and clinical activity score evaluation were associated with visual recovery.
Conclusions: In this study, we standardized the endoscopic deep medial orbital decompression, of which key point was to relieve pressure in the orbital apex and achieved satisfactory visual recovery in DON patients.
Computational biology predicts metabolic engineering targets for increased production of 102 valuable chemicals in yeast
Authors: Domenzain Iván , Lu Yao , Shi Junling , Lu Hongzhong , Nielsen Jens
Published: February 2023

Development of efficient cell factories that can compete with traditional chemical production processes is complex and generally driven by case-specific strategies, based on the product and microbial host of interest. Despite major advancements in the field of metabolic modelling in recent years, prediction of genetic modifications for increased production remains challenging. Here we present a computational pipeline that leverages the concept of protein limitations in metabolism for prediction of optimal combinations of gene engineering targets for enhanced chemical bioproduction. We used our pipeline for prediction of engineering targets for 102 different chemicals using Saccharomyces cerevisiae as a host. Furthermore, we identified sets of gene targets predicted for groups of multiple chemicals, suggesting the possibility of rational model-driven design of platform strains for diversified chemical production.
The state of the incidence and mortality of hepatitis B in China from 2004 to 2021: A spatiotemporal characteristics and trend analysis
Authors: Zhang Mengge , Li Chuancang , Cai Qian , Qu Mengbing , Meng Jingjing , Fan Haohao , Sun Liang
Published: February 2023

Objective: To describe the spatiotemporal characteristics and trend of incidence and mortality of hepatitis B in China from 2004 to 2021 and to identify its possible hotspots and potential high-risk areas for the disease.
Methods: Time trends in hepatitis B incidence and mortality were analyzed using Joinpoint regression models, and annual percentage change (APC) and average annual percentage change (AAPC) were calculated stratified by age. The spatial autocorrelation analysis of GeoDa and the space-time scanning analysis of SaTScan software were used to identify potential changes and regional differences in the spatial and temporal distribution of hepatitis B humans in China during the study period.
Results: From 2004 to 2021, the number of hepatitis B cases in China increased from 916,396 in 2004 to 976,233 in 2021 (AAPC=0.31%, P=0.665), and the number of deaths decreased from 783 in 2004 to 413 in 2021 (AAPC=-3.23%, P =0.076). There was an increasing trend of standardized incidence of hepatitis B in the age group over 30 years. The High-High cluster areas of incidence rate of hepatitis B in China from 2004 to 2012 were mainly concentrated in the northwest,and in the southeast from 2017 to 2021 were concentrated, while the High-Low cluster areas of mortality rate of hepatitis B were mainly concentrated in Beijing and Shanghai from 2004 to 2019.The results of space–time cluster analysis for incidence rate of hepatitis B in China from 2004 to 2018 included one primary clustering area and two secondary clustering areas. The primary clustering area was located in the west of China, including Tibet, Qinghai, Xinjiang and Gansu, and the high-risk time frame was from January 2006 to December 2012 (RR = 2.78, LLR = 300786.49, P  < 0.001). The results of space–time cluster analysis for mortality rate of hepatitis B in China from 2004 to 2018 included one primary clustering area and two secondary clustering areas. The primary clustering area was located in Beijing of China, and the high-risk time frame was from January 2007 to December 2013 (RR = 12.14, LLR = 1120.197907, P  < 0.001).
Conclusion: The overall trend incidence and mortality of hepatitis B in China has decreased over the 18-year period, but the number of hepatitis B incidences is on the rise. The spatial distribution of hepatitis B incidence rate in each region of the country had spatial positive correlation.Hepatitis B incidence and mortality rates vary widely in China with different epidemiologic trends affecting different locations and revealing different spatial changing patterns.
Impacts of development of acute-on-chronic liver failure and bacteria infections on pancreatic β-cell function and glucose homeostasis in patients with liver cirrhosis
Authors: Liu Yujuan , Hu Han , Li Chuan , Zhang Yin , Li Meichuan , Lu Tao , Wu Yunchong , Yang Yanyan , Li Ying , Yang Fangwan , Shi Xiuquan , De Lin Shi
Published: February 2023

Background/PurposeGlucose metabolism disorders (GMDs), including diabetes and impaired glucose tolerance, is a common complication and associated with poor prognosis in patients with liver cirrhosis. The aim of this study was to investigate the impacts of development of acute-on-chronic liver failure (ACLF) and bacteria infections (BIs) on pancreatic β-cell function and glucose homeostasis in patients with acute deterioration of liver cirrhosis.MethodsThree hundred and twenty seven patients with acute deterioration of liver cirrhosis were retrospectively included. Oral glucose tolerance test (OGTT) and OGTT-based β cell function indices were used to evaluate pancreatic β-cell function and disturbance in glucose homeostasis. Univariate and multivariate logistic regression were used to identify independent risk factors associated with GMDs.ResultsDevelopment of ACLF or BIs significantly increased the prevalence of GMDs. ACLF or BIs also significantly increased level of homeostasis model of assessment 2-insulin resistance (HOMA2-IR). ACLF but not BIs significantly impaired the glucose-stimulated insulin secretion as assessed using insulinogenic index (IGI). Patients with GMDs had a significantly lower level of IGI than that in patients without GMDs. Prothrombin activity (OR=0.981, 95% CI: 0.960~0.995), HOMA2-IR (OR=1.749, 95% CI: 1.130~2.707) and IGI (OR=0.963, 95% CI: 0.947~0.978) were the independent risk factors associated with GMDs in patients with acute deterioration of liver cirrhosis.ConclusionsIn patients with liver cirrhosis, development of ACLF impairs glucose-stimulated insulin secretion of pancreatic β-cell, both liver impairment and BIs increase insulin resistance and contribute to aggravation of disturbance in glucose
Differences in Cardiac Rupture and Hemopericardium Caused by Blunt Chest Injury, Acute Myocardial Infarct, Aortic Dissection and CPR
Authors: Xiao Ning , Miao Qi , Zhang Yan-Lin , Yu Yan-Geng , Zhang Fu , Li Dong-Ri
Published: February 2023

Objective
In this study, the hemopericardium volume and pathological characteristics associated with cardiac ruptures caused by blunt violence, AMI, aortic dissection and CPR have been analyzed. The findings might provide reference and data support for deciphering the cause of heart rupture in forensic pathology.
Method
Pericardial water-injection tests were conducted in 22 noncardiac death subjects. Other study groups included 9 cases of myocardial infarction, 20 cases of aortic dissection rupture, 11 cases of cardiac rupture caused by trauma and 4 cases of cardiac rupture by CPR. The volume of hemopericardium and the pathological features were analyzed for each group.
Result
The hemopericardium volume in myocardial infarction and dissecting aneurysm rupture were significantly higher than the pericardial injection test in noncardiac subjects (p-value < 0.01). The traumatic cardiac rupture cases had a large range in hemopericardium volume and no significant difference was observed with respect to non-cardiac death cases (p-value > 0.05). The volume of hemopericardium in CPR-induced cardiac rupture had no difference with non-cardiac rupture and it was significantly lower than the pericardial injection test (p-value < 0.01).
Conclusion
Differences in the volume of hemopericardium induced by different causes of cardiac rupture were observed. It may be related to the state of the cardiac systolic functions during an event of a rupture. The volume of hemopericardium can be used as reference data to determine the mechanism of the rupture. This could also be beneficial in cases of cardiac rupture with similar morphological and pathological features such as severe blunt chest injury and CPR.
Investigating of Risk Factors Associated with Exposure to Road Traffic Accidents among Drivers, El-Obeid, North Kordofan State, Sudan; A Cross-sectional Study
Authors: Mohammed Musa , Abdullahi Abdirahman , Barakat Abdollh
Published: February 2023

Background and objective: Road traffic accidents (RTA) represent a major important public health problem in our country and play a major role in lifelong disabilities as well as high mortality. In Sudan, the rate of road traffic accidents has recently increased for reasons related to excessive speed, and the collapse of most national roads.
Materials and Methods: A cross-sectional descriptive study of all vehicles drivers. It was carried out in Jun 2017 to January 2018, to study of risk factors associated with road traffic accidents. Data were entered and analyzed using the Statistical Package of Social Sciences (SPSS) version (16.0) and Microsoft Excel (2010) software. Chi-square (χ2) was used to determine whether there is a significant association between different variables. Values were considered to be statistically significant when the p-value obtained was less than (0.05) and assessed strength of correlation using Odd Raito (OR) with 95% confidence intervals (CI).
Results: The study included (296) vehicles drivers, all drivers who were interviewed were male. Majority (87.8%) of them has a driving license and (51%) use a seat belt while driving. Use earphones (MP3) while driving [p= 0.001, OR 22.241; 95% CI (21.896, 22.606)], use cell phone while driving [p= 0.001, OR 21.430; 95% CI (21.182, 21.726)], doping consumption [p= 0.001, OR 21.488; 95% CI (21.194, 21.791)], alcohol drinking [p= 0.001, OR 20.737; 95% CI (20.501, 20.971)], use drugs [p= 0.001, OR 22.241; 95% CI (21.877, 22.631)], suffering from low vision [p= 0.001, OR 20.794.665; 95% CI (20.553, 21.033)] and condition of the brakes[p= 0.052, OR 20.754; 95% CI (20.515, 20.977)] were significantly associated with RTAs.
Conclusion: There is need for accelerate the of laws against stimulants consumption and excessive speed among vehicles drivers and motorcyclists during driving by local authorities in order to reduce RTAs.
Big cats like water: occupancy patterns of jaguar in a unique and insular Brazilian Amazon ecosystem
Authors: Duarte Herbert Barbosa , Carvalho William Mustin , Toledo José Julio , Rosalino Luis Miguel
Published: February 2023

Patterns of detectability and occupation of the jaguar (Panthera onca) vary throughout its distribution, being determined primarily by vegetation cover, prey availability, and anthropogenic factors. However, there is still a large knowledge gap regarding what determines jaguar occupancy, especially in the Amazon. This knowledge gap is even more pronounced for oceanic islands, which represent unique and very sensitive ecosystems, such as the Maracá-Jipioca Islands of the Northeastern Brazilian Amazon. Our study aimed to establish the spatial ecology of jaguars in this insular ecosystem and to provide information to facilitate sustainable management of the population there. We assessed how different factors (vegetation type and prey availability) potentially influence detectability and occupancy patterns of the jaguars of the Maracá-Jipioca Islands. We found that greater wetland (beach-sea and lagoon-channel) cover was the main driver of jaguar detectability and occupancy. We reveal factors driving the population and spatial ecology of jaguars in an insular system. Despite imminent threats to the region, the knowledge we present can inform the sustainable management of jaguars to ensure that the fundamental and unique ecosystem services provided by this top predator are maintained.
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt- mTOR signaling
Authors: Jaime Diego , Fish Lauren A. , Madigan Laura A. , Ewing Madison D. , Fallon Justin R.
Published: February 2023

Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor that promotes and shapes BMP signaling. MuSK is expressed at all neuromuscular junctions and is also present extrasynaptically in the slow soleus muscle. To investigate the role of the MuSK-BMP pathway in vivo we generated mice lacking the BMP-binding MuSK Ig3 domain. These ∆Ig3-MuSKmice are viable and fertile with innervation levels comparable to wild type. In 3-month-old mice myofibers are smaller in the slow soleus, but not in the fast tibialis anterior (TA). Transcriptomic analysis revealed soleus-selective decreases in RNA metabolism and protein synthesis pathways as well as dysregulation of IGF1-Akt-mTOR pathway components. Biochemical analysis showed that Akt-mTOR signaling is reduced in soleus but not TA. We propose that the MuSK-BMP pathway acts extrasynaptically to maintain myofiber size in slow muscle by promoting protein synthetic pathways including IGF1-Akt-mTOR signaling. These results reveal a novel mechanism for regulating myofiber size in slow muscle and introduce the MuSK-BMP pathway as a target for promoting muscle growth and combatting atrophy.
Quality Indicators in Three Coffee Production Agrosystems
Authors: Fernández Abraham de Jesus Romero , González Rogelio Carrillo , Cabrera Braulio Edgar Herrera , Chávez Ma. del Carmen González
Published: February 2023

Healthy soil is a fundamental resource against hunger; it contributes to mitigating climate change and ensures sustainable production. The economic and social importance of coffee requires taking measures to promote its sustainable production. Shaded coffee production systems offer valuable ecosystem services indispensable for product diversification. In this context, we compared the quality of the soil, foliage, and seed of three coffee production systems: under mango shade (CM), under banana shade (CB), and under the full sun (CS). Using principal component analysis, we selected the minimum data set to designate quality indicators. For soil, the quality indicators were pH, cation exchange capacity, N content, the concentration of Ca, Mg, K, Fe, soil moisture, percentage specific conductance, soil penetration resistance and the number of worms. Foliar indicators corresponded to N content, the concentration of K, Ca, Fe, Cu, and Chlorophyll b; and seed indicators were concentration of P, K, Ca, Mg, Zn, and Cu. The soil quality index was moderate in the shaded coffee production systems, but deficient in the CS system. Foliar quality was very high in the CM system, moderate in CB and low in CS. Seed yield was low in the three systems. This research shows the main indicators influencing not only soil quality but also plant and seed nutrition in the three systems. Knowledge of the indices will allow establishing of better agronomic management practices in the shaded systems, improving soil fertility, plant nutrition, and coffee seed quality.
Accumulation Characteristics and Health significance of As, Cd and Cr Elements in Different Plants
Authors: Wang Lu , Zou Runyan , Han Yuejiang , Tan Zhengxi , Xie Yingkai , Yang Hao , Su Huiyue , Yu Huan , Zhu Zhiqiang , Song Yingqiang
Published: February 2023

To evaluate the impacts of vegetable and soil variables on phytoaccumulation of arsenic (As), cadmium (Cd) and chromium (Cr) and identify their interactions and predictors, 33 paired soil-vegetable samples were collected from the production areas of celery (Oenanthe javanica), green onion (Allium), pak choy (Brassica rapa subsp. chinensis), rape (Brassica campestris L.) and spinach (Spinacia olearacea) in the Wuqing District of Tianjin, China. The concentrations (mean ± sd in mg kg-1) of As, Cd, and Cr were 12.9 ± 2.4, 0.21 ± 0.19, 68.2 ± 11.2 in soils, respectively, higher than their soil backgrounds, and 0.19 ± 0.13, 0.17 ± 0.11, and 1.33 ± 0.94 in shoots (leaves & stems) of all vegetables, respectively. Only Pak Choy’s Cd was significantly higher than its soil concentration and threshold. All vegetables, except green onion, with the lowest concentration of As, Cd, and Cr have been heavily contaminated with Cr. For all vegetables except spinach, Cd concentration in shoots can be well predicted with 0.1M HCl extracted soil Cd (clCd) (R2 > 0.75) with soil clNi; and shoot Cr concentration with shoot Fe (stFe) for celery, pok choy, rape, and spinach (R2 > 0.90).Generally, the concentration of As, Cd, and Cr in shoots depends not only on the availability of their specific forms in soil and soil pH but also on the interactions with other elements (especially Fe) in shoots, despite their variations with vegetable species. Both Cd and Cr have a high accumulation potential, which can be better predicted with either 0.1M HCl extractable soil Cd or Fe concentration in shoots. So, how a trace element interacts with other ingredients and its specific form in the soil should be seen as essential factors in how it gets into the shoots.
Living Alone and Loneliness in Predicting Health-Related Quality of Life: Results from the Healthy Aging Longitudinal Study in Taiwan (HALST)
Authors: Tseng Han-Yun , Lee Chun-Yi , Wu Chi-Shin , Wu I-Chien , Chang Hsing-Yi , Hsu Chih-Cheng , Hsiung Chao Agnes
Published: February 2023

Purpose.
This study examined two related but distinct features of social isolation – living alone and loneliness – concerning their unique and joint effects on predicting health-related quality of life (HRQoL). In addition, we examined the moderating and mediating role of loneliness in the associations between living alone and HRQoL.
Method.
Analyses were with a nationally representative sample of 5,012 community-residing adults aged 55 and older (Mage = 59.3, SD = 8.1) and with their follow-up data 3.2 years later.
Results.
At baseline, 9% (n = 508) reported living alone, and 10.3% (n = 586) reported feeling lonely. 2.5% (n = 130) reported both living alone and feeling lonely. A series of regression showed that loneliness was consistently associated with lower physical (PCS) and mental (MCS) components of HRQoL, concurrently and longitudinally, whereas living alone was only associated with lower PCS 3.2 years later. Moderation analysis showed compounded effects of loneliness and living alone in predicting lower MCS. Mediation analyses revealed a cascading effect where living alone was associated with concurrent and subsequent loneliness, which, in turn, was associated with lower PCS and MCS 3.2 years later.
Conclusion.
Loneliness appeared to be a more potent predictor of lower HRQoL in later life. Nevertheless, living alone could indirectly worsen adults’ HRQoL by either exacerbating the negative impacts of loneliness or triggering a sense of prolonged loneliness predicting lower HRQoL. For practice, programs and policies to improve adults’ HRQoL should pay special attention to older adults who report loneliness, especially those who live alone.
RAD-Blood: a database to identify RNAs in blood as potential biomarkers of Alzheimer's disease by integrating bulk- and single-cell transcriptome profile
Authors: Duan Ting-Ting , Li Jin-Quan , Chu Jin-Yu , Li Xin-Wen , Pan Shi-Yao , Tan Wei , Zeng Yan , Hu Fei-Fei
Published: February 2023

Background
The early diagnosis of Alzheimer's disease (AD) in large-scale high-risk population is a major challenge. Blood-based biomarkers could enable widespread testing for AD. RNA-seq technology is becoming an effective method in investigating diagnostic biomarkers for diseases, but platforms exploring RNA-seq data in AD blood are lacking.
Methods
We collected the raw RNA-seq data in the blood of AD patients or AD mouse models, mild cognitive impairment (MCI) patients, and normal people or wild type mouse from the Gene Expression Omnibus (GEO) and Synapse databases. And the RNA-seq data was analyzed by the standard pipeline. We applied R-Shiny to develop the website of RAD-Blood (RNA-seq analysis of AD blood, http://www.bioinform.cn/RAD-Blood/) to present the plentiful analysis results.
Results
RAD-Blood was specifically designed to analyze existing blood RNA-seq data sets (mRNA-seq, miRNA-seq, and scRNA-seq) from patients and mouse models with AD pathology. The RAD-Blood provides differential expression, gene set enrichment, immune abundance and its correlation with gene expression, cell type annotation, T cell receptor, and cell communication analyses for RNA-seq data in AD/MCI/normal blood, with rich results forms and colorful figures. We used a case study to show the capacity of RAD-Blood in finding blood biomarkers in AD/MCI blood. By using RAD-Blood, we found 274 protein-coding genes whose mRNA expression was consistently up-regulated or down-regulated from normal to MCI to AD. Among the consistently down-regulated genes, four are the markers of the blood erythroid cell. Compared with normal people, the population of erythroid cells in AD patients decreased. Despite the reduction in cell count, interactions between blood erythroid cells with other cells increased dramatically, which is mainly mediated through the major histocompatibility complex I (MHC-I) signaling pathway. These findings have not been reported by existing studies, which suggests that RAD-Blood is a solution for finding potential novel signatures in the blood of AD and MCI.
Conclusions
RAD-Blood is a user-friendly web server for multi-level analysis and visualization of gene/miRNA expression and immune profile in AD blood, and allows broad utility in exploring potential AD blood biomarkers, testing hypotheses, guiding experiment design, and investigating the peripheral pathogenic mechanisms and proposing potential early diagnosis standard of AD.
Prevalence of Serum Immunoglobulin A Antibodies Reactive to Severe Acute Respiratory Syndrome Coronavirus 2 in Healthy College Students and Employees: A Preliminary Study in Sudan
Authors: Mahmoud Motaz Mohammed , Yasin Ola Hassan , Atabani Nafisa Mahmoud , Mohammed Riyadh Abdulsalam , Mohammed Samah said Ahmed , Bakheit Abdullah M , Hajhamed Nooh Mohamed , Ismail Salahaldeen , Mengistu Samuel Tekle , Hamida Mohammed Elfatih
Published: February 2023

The SARS-CoV-2-caused COVID-19 pandemic has posed a severe danger to worldwide public health. While several nations have recorded high rates of occurrence, Sudan has reported a comparably low number of instances. To investigate this phenomenon, we conducted a preliminary investigation to determine the frequency of immunoglobulin A (IgA) antibodies reactive to SARS-CoV-2 in healthy Sudanese college students and employees. Using an enzyme-linked immunosorbent assay, we collected blood samples from 80 individuals and evaluated serum IgA antibodies reactive to the receptor binding region of SARS-CoV-2 spike-1 subunit proteins. Our primary finding was that 17.5% (95% CI 9.97–27.6) of those who asymptomatic to SARS-CoV-2 tested positive for serum IgA antibodies, with a broad range of values of the grand median of the optical density (OD) of 0.083 (IQR: 0.049–0.13) ng/ml. We discovered a downward trend in antibody positivity with increasing age. According to our early findings, IgA antibodies reactive to SARS-CoV-2 are found in asymptomatic Sudanese college students and staff. This discovery may shed light on the comparatively low prevalence of COVID-19 in Sudan. Further study is needed to look into the potential protective impact of pre-existing IgA antibodies against SARS-CoV-2 and to understand the underlying processes.
RESEARCH OF THE INFLUENCE OF THE ORGANIZATIONAL DEVELOPMENT MANAGEMENT SYSTEM OF THE ENTERPRISE ON ITS COMPETITIVENESS
Authors: Kotenko Stanislav , Onishchenko Svitlana , Korz Anna
Published: February 2023

Organizational development is a vital tool in planning and managing the growth and expansion of an enterprise or business. The growth analysis process is used to determine the rate at which a business can grow and expand healthily. The result of these determinations is a change in the enterprise's business plan combined with recommendations for redirecting the company's resources. These recommendations include all resources, from financial to human resources. Another area where organizational development is critical is in analyzing business workflows for accuracy and efficiency. The end result of such efforts is the implementation of certain quality control standards. These standards are derived from a detailed report prepared during the development of the organization. Recommendations can include anything from eliminating certain processes to combining others. A factor analysis of the advantages that may arise when creating a system of organizational development at the enterprise will have a positive impact not only on increasing the competitiveness of Ukrainian enterprises, but also can stimulate changes in personnel work, the organization of production processes and the planning procedure. The purpose of the article is to identify and systematize the factors of influence of the management system of organizational development of the enterprise on its competitiveness. In the process of research, a systematic approach to defining the concept of "organizational development", general methods of scientific knowledge (analysis, synthesis, deduction, induction), as well as bibliographic analysis, structural analysis, and factor analysis of possible advantages of implementing the organizational development system were used.
The results of the study are an analysis of the features and modern trends in the implementation of the organizational development system at enterprises and organizations; systematization of factors influencing organizational development on the organization's competitiveness; determination of the particularity of the influence of the human factor as such, which characterizes organizational development, various intervention techniques were investigated.
Prospective areas of further research are the use of factor analysis methods to determine the relationship between the organization's life cycle and the need to form a system of organizational development of enterprises in Ukraine. The results of the research can be implemented in the work practices of enterprises of any industry.