bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Magnetically Separable CuFe2O4 Nanoparticles Catalyzed Ligand‐Free C—S Coupling in Water: Access to (E)‐ and (Z)‐Styrenyl‐, Heteroaryl and Sterically Hindered Aryl Sulfides.
Authors: Kundu Debasish , Chatterjee Tanmay , Ranu Brindaban C.
Published: February 2014

The reaction shows high functional group tolerance and is applied to a wide range aromatic and heteroaromatic substituents in bromides or iodides and thiols.
ChemInform Abstract: PhI(OAc)2/KI Mediated 1,2‐Acetoxysulfenylation of Alkenes: Facile Synthesis of β‐Acetoxysulfides.
Authors: Muangkaew Charoensak , Katrun Praewpan , Kanchanarugee Patcharaphon , Pohmakotr Manat , Reutrakul Vichai , Soorukram Darunee , Jaipetch Thaworn , Kuhakarn Chutima
Published: February 2014

KI promoted oxidative addition of (diacetoxyiodo)benzene and diaryldisulfides allows a facile synthesis of 1,2‐acetoxysulfides from alkenes.
ChemInform Abstract: Nickel(II) Chloride Hexahydrate Catalyzed Reaction of Aromatic Aldehydes with 2‐Mercaptoethanol: Formation of Supramolecular Helical Assemblage of the Product.
Authors: Laskar Rajibul A. , Begum Naznin A. , Mir Mohammad Hedayetullah , Rohman Md. Rumum , Khan Abu T.
Published: February 2014

The title reaction produces unexpected dithioacetals (III) as major products along with minor amounts of the expected 1,3‐oxathiolanes.
ChemInform Abstract: Copper‐Catalyzed Direct Oxysulfonylation of Alkenes with Dioxygen and Sulfonylhydrazides Leading to β‐Ketosulfones.
Authors: Wei Wei , Liu Chunli , Yang Daoshan , Wen Jiangwei , You Jinmao , Suo Yourui , Wang Hua
Published: February 2014

A novel copper‐catalyzed direct oxysulfonylation of alkenes (I) and (IV) with dioxygen and sulfonylhydrazides (II) to furnish β‐ketosulfones (III) and (V), resp., is reported.
ChemInform Abstract: Modulation of Multifunctional N,O,P Ligands for Enantioselective Copper‐Catalyzed Conjugate Addition of Diethylzinc and Trapping of the Zinc Enolate.
Authors: Ye Fei , Zheng Zhan‐Jiang , Deng Wen‐Hui , Zheng Long‐Sheng , Deng Yuan , Xia Chun‐Gu , Xu Li‐Wen
Published: February 2014

The novel catalyst is effective in the asymmetric conjugate addition reaction of Et2Zn to enones and tandem silylation and acylation of enantioenriched zinc enolates.
ChemInform Abstract: Rhodium‐Catalyzed Dynamic Kinetic Asymmetric Transformations of Racemic Allenes by the [3 + 2] Annulation of Aryl Ketimines.
Authors: Tran Duc N. , Cramer Nicolai
Published: February 2014

The title reaction proceeds in a high regio‐, enantio‐, and diastereoselective manner for the allene incorporation.
ChemInform Abstract: Synthesis of Arylated Anthraquinones by Site‐Selective Suzuki—Miyaura Reactions of the Bis(triflates) of 1,3‐Di(hydroxy)anthraquinones.
Authors: Akrawi Omer A. , Khan Afsar , Patonay Tamas , Villinger Alexander , Langer Peter
Published: February 2014

While the reaction of the anthraquinones (I) and (IV) proceeds with very good selectivity, similar reactions of the compound (VIII) are not selective.
ChemInform Abstract: Cascade Cyclizations of Acyclic and Macrocyclic Alkynones: Studies Toward the Synthesis of Phomactin A.
Authors: Ciesielski Jennifer , Gandon Vincent , Frontier Alison J.
Published: February 2014

A study of the reactivity and diastereoselectivity of the Lewis acid promoted cascade cyclizations of both acyclic and macrocyclic alkynones is described.
ChemInform Abstract: Fluoroalkanosulfonyl Fluorides‐Mediated Cyclodehydration of β‐Hydroxy Sulfonamides and β‐Hydroxy Thioamides to the Corresponding Aziridines and Thiazolines.
Authors: Yan Zhaohua , Guan Chengbo , Yu Zhangxin , Tian Weisheng
Published: February 2014

An efficient method for the perfluorobutanesulfonyl fluoride‐induced cyclodehydration of β‐hydroxy sulfonamides and β‐hydroxy thioamides to the corresponding aziridines and thiazolines is reported.
ChemInform Abstract: Synthesis of Fused‐β‐Lactams Through Selective Gold‐Catalyzed Oxycyclization of Dioxolane‐Tethered Enynes.
Authors: Alcaide Benito , Almendros Pedro , Martinez del Campo Teresa , Torres M. Rosario
Published: February 2014

The gold‐catalyzed preparation of 2‐azetidinone‐fused oxacycles is accomplished from β‐lactam‐linked enynes through heterocyclization reaction taking advantage of the acetonide pendant group.
ChemInform Abstract: Palladium‐Catalyzed Carbene Migratory Insertion Using Conjugated Ene—Yne—Ketones as Carbene Precursors.
Authors: Wang Jianbo , et al. et al.
Published: February 2014

The reaction is proposed to proceed via oxidative addition, alkyne activation—cyclization, palladium carbene migratory insertion and β—hydride elimination followed by catalyst regeneration.
ChemInform Abstract: Visible Light Photoredox Atom Transfer Ueno—Stork Reaction.
Authors: Gu Xiangyong , Lu Ping , Fan Weigang , Li Pixu , Yao Yingming
Published: February 2014

The light‐promoted Ueno—Stork reaction of propargyl esters (I) yields desired tetrahydrofuran vinyl iodides (II).
ChemInform Abstract: Trifluoromethanesulfonic Acid Catalyzed Synergetic Oxidative/[3 + 2] Cyclization of Quinones with Olefins.
Authors: Meng Lingkui , Zhang Guanghui , Liu Chao , Wu Kun , Lei Aiwen
Published: February 2014

A synthesis of tetrahydrobenzodifurans and tetrahydrobenzofurans in a TfOH‐catalyzed direct C‐H functionalization of benzoquinone and naphthoquinone with olefins is presented.
ChemInform Abstract: Phosphazene‐Catalyzed Intramolecular Cyclization of Nitrogen‐Tethered Alkynyl Esters.
Authors: Kondoh Azusa , Ando Kenichi , Terada Masahiro
Published: February 2014

The phosphazene‐catalyzed intramolecular addition of enolates of simple esters to alkynes is reported.
ChemInform Abstract: α‐Vinylation of Amides with Arylacetylenes: Synthesis of Allylamines under Metal‐Free Conditions.
Authors: Sun Manman , Wu Huandong , Bao Weiliang
Published: February 2014

A novel method is reported for the preparation of allylamines (III) by a solvent‐free oxidative α‐vinylation of amides (II) with arylacetylenes (I).
ChemInform Abstract: Modular CeCl3·7H2O‐Catalyzed Multi‐Component Synthesis of 1,2,3,4‐Tetrasubstituted Pyrroles under Microwave Irradiation and Their Further Trichloroisocyanuric Acid‐Mediated Conversion into 5‐Sulfenylpyrrole Derivatives.
Authors: Silveira Claudio C. , Mendes Samuel R. , Martins Guilherme M. , Schloesser Sheila C. , Kaufman Teodoro S.
Published: February 2014

A multicomponent synthesis of 1,2,3,4‐tetrasubstituted pyrroles promoted by cerous chloride is carried out under microwave irradiation.
ChemInform Abstract: The Ammonium‐Promoted Formylation of Indoles by DMSO and H2O
Authors: Fei Haiyang , Yu Jintao , Jiang Yan , Guo Huan , Cheng Jiang
Published: February 2014

20 examples
ChemInform Abstract: Synthesis of Highly Functionalized Dihydrobenzofurans and Indolines by Palladium‐Catalyzed Mizoroki—Heck—Heteroannulation Cascade Reactions of Alkoxy‐1,3‐dienes.
Authors: Toppino Antonio , Arru Paolo , Bianco Niccolo , Prandi Cristina , Venturello Paolo , Deagostino Annamaria
Published: February 2014

The products can be further transformed into ketones, e.g. benzofuran (IV), in quantitative yields.
ChemInform Abstract: Regioselective Synthesis of Elusive 4,9‐Dihydro‐1H‐carbazoles by Gold‐Catalyzed Cycloisomerization of 3‐Allenylmethylindoles.
Authors: Alvarez Estela , Garcia‐Garcia Patricia , Fernandez‐Rodriguez Manuel A. , Sanz Roberto
Published: February 2014

A general and efficient synthesis of carbazoles from 3‐allenylmethylindoles is reported.
ChemInform Abstract: A Short Synthesis of Polyhydroxylated Pyrrolizidines via Sequential 1,3‐Dipolar Cycloaddition and Reductive Amination.
Authors: Gkizis Petros , Argyropoulos Nikolaos G. , Coutouli‐Argyropoulou Evdoxia
Published: February 2014

A series of pyrrolizidines bearing a methyl group at C‐5 are synthesized by 1,3‐dipolar cycloaddition of five‐membered cyclic nitrones with methyl vinyl ketone.
ChemInform Abstract: Regioselective Synthesis of 1,3,4,5‐Tetrasubstituted Pyrazoles from α‐Alkenyl‐α,β‐enones Derived from Morita—Baylis—Hillman Adducts.
Authors: Kim Sung Hwan , Lim Jin Woo , Yu Jin , Kim Jae Nyoung
Published: February 2014

The reaction of α‐alkenyl‐α,β‐enones with hydrazine derivatives in o‐dichlorobenzene under nitrogen atmosphere yields 4‐arylethylpyrazoles (III) whilst similar reaction in EtOH under O2 atmosphere gives selectively 4‐styrylpyrazoles [cf.
ChemInform Abstract: Improved Preparation of 1,3‐Bis(2,6‐di‐iso‐propylphenyl)imidazolium Tetrafluoroborate.
Authors: Briggs Andrew J.
Published: February 2014

Title compound (V) is prepared in a multi‐hundred‐gram scale with an overall yield of 61% from commercially available aniline (I).
ChemInform Abstract: Practical Oxazole Synthesis Mediated by Iodine from α‐Bromoketones and Benzylamine Derivatives.
Authors: Gao Wen‐Chao , Wang Ruo‐Lin , Zhang Chi
Published: February 2014

A variety of oxazole derivatives including alkaloid halfordinol (VIII) is readily prepared by a oxidative cyclization of bromoketones with amines.
ChemInform Abstract: Catalyst Free, Regioselective One‐Pot Three‐Component Synthesis of Thiazol‐2‐imine Derivatives in Ionic Liquid.
Authors: Kumar G. Santosh , Ragini S. Pushpa , Meshram H. M.
Published: February 2014

The reaction is conducted under environmentally benign conditions in ionic liquid.
ChemInform Abstract: Synthesis and Binding Affinity of New 1,4‐Disubstituted Triazoles as Potential Dopamine D3 Receptor Ligands.
Authors: Insua Ignacio , Alvarado Mario , Masaguer Christian F. , Iglesias Alba , Brea Jose , Loza Maria I. , Carro Laura
Published: February 2014

A series of new 1,4‐disubstituted triazoles (V) are synthesized using click chemistry methodology and evaluated as potential ligands on several subtypes of dopamine receptors.
ChemInform Abstract: Halonium‐Initiated Double Oxa‐Cyclization Cascade as a Synthetic Strategy for Halogenated Furo[3,2‐c]pyran‐4‐ones.
Authors: Wei Enxiang , Liu Bing , Lin Shaoxia , Zhao Baozhong , Liang Fushun
Published: February 2014

A simple method is reported for the preparation of 7‐halogenated furo[3,2‐c]pyran‐4‐ones (II) and (III) by a double oxa‐cyclization of cyclopropanecarboxylic acids (I).
ChemInform Abstract: Synthesis of Chromeno[2,3‐b]indole Derivatives.
Authors: Graczol‐Foerdoes Eszter , Novak Tibor , Blasko Gabor , Fejes Imre , Perron‐Sierra Francoise , Nyerges Miklos
Published: February 2014

Several new polysubstituted chromeno[2,3‐b]indole derivatives of type (VI) and (VIII) are prepared.
ChemInform Abstract: 4,6‐Diacetylresorcinol in Heterocyclic Synthesis. Part 1. Synthesis and Biological Evaluation of Some New Linearly and Angularly Substituted Pyrano[3,2‐g]chromenes via Vilsmeier—Haack Formylation of 4,6‐Diacetylresorcinol, Its Schiff Bases, and Hydrazones.
Authors: Ali Tarik E. , Ibrahim Magdy A. , El‐Gendy Zeinab M. , El‐Amin Eman M.
Published: February 2014

Most products are shown to have weak antimicrobial activities, and dicarboxaldehydes [(III) and (V)] exhibit moderate antibacterial activity against Gram‐positive bacteria, yeast, and fungus.
ChemInform Abstract: An Efficient Synthesis of Poly‐Substituted Phenols and Pyridines from Morita—Baylis—Hillman Acetates and Diethyl Oxalacetate.
Authors: Yu Jin , Kim Ko Hoon , Lee Hyun Ju , Kim Jae Nyoung
Published: February 2014

Various phenol derivatives (III) synthesized by a one‐pot reaction of Morita—Baylis—Hillman acetates and sodium diethyl oxalacetate via a [4 + 2]‐cyclization.
ChemInform Abstract: Microwave‐Assisted One‐Pot Synthesis of Bioactive Ugi‐4CR Using Fluorite as Benign and Heterogeneous Catalyst.
Authors: Mohanram Ipsita , Meshram Jyotsna , Shaikh Ambareen , Kandpal Bhavna
Published: February 2014

Ugi derivatives (V) are synthesized and screened for their potential antibacterial activities.
ChemInform Abstract: Catalytic Synthesis of Polyhydroquinolines by Lithium Perchlorate in Polyethylene Glycol.
Authors: Wu Chunlei , Shen Runpu , Tao Feifei , Gao Xiaozhong , Deng Liping , Zhou Yubo
Published: February 2014

An effective synthesis of polyhydroquinoline derivatives via a four‐component one‐pot reaction of aromatic aldehydes, dimedone, ethyl acetoacetate, and ammonium acetate is presented.
ChemInform Abstract: A Facile Eco‐Friendly One‐Pot Five‐Component Synthesis of Novel 1,2,3‐Triazole‐Linked Pentasubstituted 1,4‐Dihydropyridines and Their Biological and Photophysical Studies.
Authors: Singh Harjinder , Sindhu Jayant , Khurana Jitender M. , Sharma Chetan , Aneja Kamal R.
Published: February 2014

New dihydropyridines (VII) (16 examples) are readily prepared by a multicomponent synthesis under ultrasonic or microwave irradiation in PEG‐400.
ChemInform Abstract: Intramolecular Diels—Alder Furan‐Mediated Synthesis of 8‐Aryl‐3,4‐dihydroisoquinolin‐1(2H)‐ones, Convenient Precursors of Indenol[1,2,3‐ij]isoquinolines.
Authors: Treus Monica , Harwood Laurence M. , Estevez Juan C. , Salas Cristian , Drew Michael G. B. , Estevez Ramon J.
Published: February 2014

A sequential intramolecular high pressure Diels—Alder reaction of furans (I) and subsequent acid‐mediated ring opening of the resulting oxabicycle gives dihydroisoquinolinones (III) in good yields.
ChemInform Abstract: The Organocatalytic Enantioselective [3 + 2] Cycloaddition Reaction of α,β‐Unsaturated Aldehydes with Azomethine Ylides Applied to the Asymmetric Synthesis of Densely Substituted Pyrroloisoquinolines.
Authors: Iza Ainara , Ugarriza Iratxe , Uria Uxue , Reyes Efraim , Carrillo Luisa , Vicario Jose L.
Published: February 2014

The synthesis of densely functionalized pyrroloisoquinolines (VIII) is reported, representing the core structure of various alkaloids.
ChemInform Abstract: A Microwave Assisted Synthesis of Highly Substituted 7‐Methyl‐5H‐thiazolo[3,2‐a]pyrimidine‐6‐carboxylate Derivatives via One‐Pot Reaction of Aminothiazole, Aldehyde and Ethyl Acetoacetate.
Authors: Zhao Bing , Jiang Li‐Li , Liu Zhuo , Deng Qi‐Gang , Wang Li‐Yan , Song Bo , Gao Yan
Published: February 2014

Optimum reactions are examined for the three‐component one‐pot synthesis of 12 title compounds (IV) under microwave irradiation.
ChemInform Abstract: Practical and Economical Approach to Synthesize Sitagliptin.
Authors: Lin Kuaile , Cai Zhengyan , Zhou Weicheng
Published: February 2014

The dipeptidyl peptidase 4 (DPP‐4) inhibitor sitagliptin phosphate monohydrate (V) is synthesized starting from compound (I) in an overall yield of 42% in four steps using the stereoselective reduction of compound (III) as the key step without the use of expensive and toxic catalysts or ligands.
ChemInform Abstract: A Donor—Acceptor Cyclopropene as a Dipole Source for a Silver(I) Catalyzed Asymmetric Catalytic [3 + 3]‐Cycloaddition with Nitrones.
Authors: Xu Xinfang , Zavalij Peter J. , Doyle Michael P.
Published: February 2014

Ag(I)‐catalyzed asymmetric formal [3 + 3]‐cycloaddition of nitrones (III) to the donor‐acceptor substituted cyclopropene (II) affords 3,6‐dihydro‐1,2‐oxazine derivatives (IV) (19 examples) in high yields with exceptional stereocontrol.
ChemInform Abstract: Synthesis of Azepine Derivatives by Silver‐Catalyzed [5 + 2] Cycloaddition of γ‐Amino Ketones with Alkynes.
Authors: Zhou Ming‐Bo , Song Ren‐Jie , Wang Cheng‐Yong , Li Jin‐Heng
Published: February 2014

A novel method for the synthesis of 2,3‐dihydro‐1H‐azepines is established using a silver‐catalyzed [5 + 2] cycloaddition of γ‐aminoketones with terminal alkynes.
ChemInform Abstract: A Simple and One‐Pot Synthesis of 2,3,4,5‐Tetrasubstituted 4,5‐Dihydro‐3H‐1,4‐benzodiazepines.
Authors: Wang Ying , Chen Min , Ding Ming‐Wu
Published: February 2014

Title compounds (V) and (VII) are synthesized in a facile one‐pot procedure by a new sequential Ugi 4CC/Staudinger/aza‐Wittig reaction.
ChemInform Abstract: Syntheses of 1,5‐Benzothiazepines. Part 40. Syntheses and Antimicrobial Studies of 10‐Substituted‐6a,7‐dihydro‐6‐(4‐methoxyphenyl/phenyl)‐7‐ (3‐nitrophenyl)‐6H‐[1]benzopyrano[3,4‐c][1,5]benzothiazepines.
Authors: Pant Seema , Dharamveer Dharamveer , Saxena Deepika
Published: February 2014

A variety of new benzopyranobenzothiazepines (III) (12 examples) are synthesized and evaluated for their antimicrobial activities.
ChemInform Abstract: Lancolides [A (Ia), B (IIa), C (Ib), D (IIb)], Antiplatelet Aggregation Nortriterpenoids with Tricyclo[6.3.0.02,11]undecane‐Bridged System from Schisandra lancifolia.
Authors: Shi Yi‐Ming , Wang Xin‐Bo , Li Xiao‐Nian , Luo Xiao , Shen Zi‐Ying , Wang Yi‐Ping , Xiao Wei‐Lie , Sun Han‐Dong
Published: February 2014

Lancolides A (Ia) and D (IIb) show specific antiplatelet aggregation induced by platelet‐activating factor (PAF).
ChemInform Abstract: Trading N and O: Asymmetric Syntheses of β‐Hydroxy‐α‐amino Acids via α‐Hydroxy‐β‐amino Esters.
Authors: Davies Stephen G. , Fletcher Ai M. , Frost Aileen B. , Lee James A. , Roberts Paul M. , Thomson James E.
Published: February 2014

The conversion of readily synthesized α‐hydroxy‐β‐amino acid derivatives to N‐protected aziridines (VII) is developed and their utilization in the synthesis of β‐hydroxy‐α‐amino acids is demonstrated.
ChemInform Abstract: Bioactive Oleanane‐Type Saponins from the Rhizomes of Anemone taipaiensis.
Authors: Wang Xiao‐Yang , Gao Hui , Zhang Wei , Li Yuan , Cheng Guang , Sun Xiao‐Li , Tang Hai‐Feng
Published: February 2014

Five new oleanane‐type triterpenoid saponins (structure example (I)), together with seven known saponins are isolated.
ChemInform Abstract: Alkaloids from Melodinus suaveolens.
Authors: Zhang Ting‐Ting , Liu Zhi‐Wen , Wang Wen‐Jing , Tong Yong‐Bin , Xu Fang‐Fang , Yuan Jing‐Quan , Liu Bo , Zhang Xiao‐Qi , Ye Wen‐Cai
Published: February 2014

2 New quinoline alkaloids (I) and (II) are isolated from the twigs and leaves of Melodinus suaveolens along with 6 known alkaloids.
ChemInform Abstract: A Short Total Synthesis of the Marine Sponge Pyrrole‐2‐aminoimidazole Alkaloid (.+‐.)‐Agelastatin A
Authors: Duspara Petar A. , Batey Robert A.
Published: February 2014

in only six manipulations in 15% overall yield
ChemInform Abstract: Development of Enantioselective Synthetic Routes to the Hasubanan and Acutumine Alkaloids.
Authors: Calandra Nicholas A. , King Sandra M. , Herzon Seth B.
Published: February 2014

A general strategy for the preparation of ten hasubanan and two acutumine alkaloids is described.
ChemInform Abstract: Heteroanellated and 7‐Deoxygenated Goniofufurone Mimics with Antitumor Activity: Design, Synthesis and Preliminary SAR Studies.
Authors: Popsavin Velimir , Francuz Jovana , Zelenovic Bojana Sreco , Benedekovic Goran , Popsavin Mirjana , Kojic Vesna , Bogdanovic Gordana
Published: February 2014

New compounds (II) and (III) show diverse growth inhibitory effects against selected tumor cell lines, but are devoid of any significant toxicity towards the normal foetal lung fibroblasts.
ChemInform Abstract: Insight into Dihalogenation of E‐Ring of Podophyllotoxins, and Their Acyloxylation Derivatives at the C4 Position as Insecticidal Agents.
Authors: Che Zhiping , Yu Xiang , Fan Lingling , Xu Hui
Published: February 2014

An unexpected sequential E‐ring double halogenation of podophyllotoxin analogues is reported.
ChemInform Abstract: Free Acidity Measurement — A Review
Authors: Srinivasan T. G. , Vasudeva Rao P. R.
Published: February 2014

Review: methods for the determination of the free acidity with emphasis on actinide cotaining solutions; 78 refs.
ChemInform Abstract: Kinetics and Mechanisms of Aggregative Nanocrystal Growth
Authors: Wang Fudong , Richards Vernal N. , Shields Shawn P. , Buhro William E.
Published: February 2014

Review: 206 refs.
ChemInform Abstract: Oxidative Etching and Its Role in Manipulating the Nucleation and Growth of Noble‐Metal Nanocrystals
Authors: Zheng Yiqun , Zeng Jie , Ruditskiy Aleksey , Liu Maochang , Xia Younan
Published: February 2014

Review: 83 refs.
ChemInform Abstract: Anisotropic Noble Metal Nanocrystal Growth: The Role of Halides
Authors: Lohse Samuel E. , Burrows Nathan D. , Scarabelli Leonardo , Liz‐Marzan Luis M. , Murphy Catherine J.
Published: February 2014

Review: 90 refs.
ChemInform Abstract: Hybrid Semiconductor—Metal Nanoparticles: From Architecture to Function
Authors: Banin Uri , Ben‐Shahar Yuval , Vinokurov Kathy
Published: February 2014

Review: 125 refs.
ChemInform Abstract: Near‐Infrared Quantum Dots and Their Delicate Synthesis, Challenging Characterization, and Exciting Potential Applications
Authors: van Veggel Frank C. J. M.
Published: February 2014

Review: 181 refs.
ChemInform Abstract: Charge Transport Dilemma of Solution‐Processed Nanomaterials
Authors: Kim Ji‐Young , Kotov Nicholas A.
Published: February 2014

Review: 336 refs.
ChemInform Abstract: Terpenes from the Soft Corals of the Genus Sarcophyton: Chemistry and Biological Activities
Authors: Liang Lin‐Fu , Guo Yue‐Wei
Published: February 2014

Review: 99 refs.
ChemInform Abstract: Trifluoroacetic Acid: Uses and Recent Applications in Organic Synthesis
Authors: Lopez Simon E. , Salazar Jose
Published: February 2014

Review: 181 refs.
ChemInform Abstract: Synthetic Developments in Functionalized Pyrano[2,3‐c]pyrazles. A Review
Authors: Myrboh Bekington , Mecadon Hormi , Rohman Md. Rumum , Rajbangshi Mantu , Kharkongor Icydora , Laloo Badaker M. , Kharbangar Iadeishisha , Kshiar Baskhemlang
Published: February 2014

Review: 97 refs.
ChemInform Abstract: Recent Synthetic Developments and Applications of the Ullmann Reaction. A Review
Authors: Lin Hao , Sun Dianqing
Published: February 2014

Review: 270 refs.
ChemInform Abstract: Recent Developments in the Synthesis and Applications of Pyrazolidines. A Review
Authors: Davis Lindsey O.
Published: February 2014

Review: 143 refs.
ChemInform Abstract: Benzenoid Polycyclic Hydrocarbons with an Open—Shell Biradical Ground State
Authors: Sun Zhe , Zeng Zebing , Wu Jishan
Published: February 2014

Review: recent progress, from both theoretical and experimental perspectives, on four types of benzenoid polycyclic hydrocarbons with an open‐shell biradical ground state: 1) acenes, 2) periacenes and anthenes, 3) zethrenes, and 4) extended p‐quinodimethane derivatives; 63 refs.
ChemInform Abstract: Enantioselective Reactions of N‐Acyliminium Ions Using Chiral Organocatalysts
Authors: Lee Yong Sup , Alam Md. Maqusood , Keri Rangappa S.
Published: February 2014

Review: 93 refs.
ChemInform Abstract: Oxidative Alkene Cleavage by Chemical and Enzymatic Methods
Authors: Rajagopalan Aashrita , Lara Miguel , Kroutil Wolfgang
Published: February 2014

Review: <100 refs.
ChemInform Abstract: Kinugasa Reaction: A Direct One‐Pot Route to Highly Functionalized β‐Lactams
Authors: Khangarot Rama K. , Kaliappan Krishna P.
Published: February 2014

Review: 104 refs.
ChemInform Abstract: Search for Ideal P‐Chiral Phosphorus Ligands for Practical Asymmetric Hydrogenation and Asymmetric Suzuki—Miyaura Coupling
Authors: Liu Guodu , Xu Guangqing , Luo Renshi , Tang Wenjun
Published: February 2014

Review: 64 refs.
ChemInform Abstract: Functionalization of the Anomeric C—H Bond of Carbohydrates: Old Strategies and New Opportunities
Authors: Boultadakis‐Arapinis Melissa , Lescot Camille , Micouin Laurent , Lecourt Thomas
Published: February 2014

Review: <100 refs.
ChemInform Abstract: Organic Superbases: The Concept at a Glance
Authors: Ishikawa Tsutomu , Harwood Laurence M.
Published: February 2014

Review: recent progress on organic superbases, including their applications; 24 refs.
ChemInform Abstract: Enantioselective Propargylation and Allenylation Reactions of Ketones and Imines.
Authors: Wisniewska Hanna M. , Jarvo Elizabeth R.
Published: February 2014

Review: 53 refs.
ChemInform Abstract: Recent Advances in Solid‐State Nuclear Magnetic Resonance Techniques to Quantify Biomolecular Dynamics
Authors: Watt Eric D. , Rienstra Chad M.
Published: February 2014

Review: 52 refs.
ChemInform Abstract: Biosynthesis: Non‐Stick Natural Products
Authors: Jordan Peter A. , Moore Bradley S.
Published: February 2014

Review: 6 refs.
ChemInform Abstract: PDE2 Inhibition: Potential for the Treatment of Cognitive Disorders
Authors: Gomez Laurent , Breitenbucher J. Guy
Published: February 2014

Review: 49 refs.
ChemInform Abstract: Nanopore‐Based Sequencing and Detection of Nucleic Acids
Authors: Ying Yi‐Lun , Zhang Junji , Gao Rui , Long Yi‐Tao
Published: February 2014

Review: 76 refs.
ChemInform Abstract: Utilization of Alkoxysilyl Groups for the Creation of Structurally Controlled Siloxane‐Based Nanomaterials
Authors: Kuroda Kazuyuki , Shimojima Atsushi , Kawahara Kazufumi , Wakabayashi Ryutaro , Tamura Yasuhiro , Asakura Yusuke , Kitahara Masaki
Published: February 2014

Review: 73 refs.
ChemInform Abstract: Playing with Structures at the Nanoscale: Designing Catalysts by Manipulation of Clusters and Nanocrystals as Building Blocks
Authors: Cargnello Matteo , Fornasiero Paolo , Gorte Raymond J.
Published: February 2014

Review: 43 refs.
ChemInform Abstract: Dispersed Phase Catalysis: Past and Future. Celebrating One Century of Industrial Development
Authors: Bacaud Robert
Published: February 2014

Review: 31 refs.
ChemInform Abstract: Progress with, and Prospects for, Metal Complexes in Cell Imaging
Authors: Coogan Michael P. , Fernandez‐Moreira Vanesa
Published: February 2014

Review: 101 refs.
Design, Synthesis and Biological Evaluation of 4‐Amino‐N‐(4‐aminophenyl)benzamide Analogues of Quinoline‐Based SGI‐1027 as Inhibitors of DNA Methylation
Authors: Rilova Elodie , Erdmann Alexandre , Gros Christina , Masson Véronique , Aussagues Yannick , Poughon‐Cassabois Valérie , Rajavelu Arumugam , Jeltsch Albert , Menon Yoann , Novosad Natacha , Gregoire Jean‐Marc , Vispé Stéphane , Schambel Philippe , Ausseil Fréderic , Sautel François , Arimondo Paola B. , Cantagrel Frédéric
Published: February 2014

Quinoline derivative SGI‐1027 (N‐(4‐(2‐amino‐6‐methylpyrimidin‐4‐ylamino)phenyl)‐4‐(quinolin‐4‐ylamino)benzamide) was first described in 2009 as a potent inhibitor of DNA methyltransferase (DNMT) 1, 3A and 3B. Based on molecular modeling studies, performed using the crystal structure of Haemophilus haemolyticus cytosine‐5 DNA methyltransferase (MHhaI C5 DNMT), which suggested that the quinoline and the aminopyridimine moieties of SGI‐1027 are important for interaction with the substrates and protein, we designed and synthesized 25 derivatives. Among them, four compounds—namely the derivatives 12, 16, 31 and 32—exhibited activities comparable to that of the parent compound. Further evaluation revealed that these compounds were more potent against human DNMT3A than against human DNMT1 and induced the re‐expression of a reporter gene, controlled by a methylated cytomegalovirus (CMV) promoter, in leukemia KG‐1 cells. These compounds possessed cytotoxicity against leukemia KG‐1 cells in the micromolar range, comparable with the cytotoxicity of the reference compound, SGI‐1027. Structure–activity relationships were elucidated from the results. First, the presence of a methylene or carbonyl group to conjugate the quinoline moiety decreased the activity. Second, the size and nature of the aromatic or heterocycle subsitutents effects inhibition activity: tricyclic moieties, such as acridine, were found to decrease activity, while bicyclic substituents, such as quinoline, were well tolerated. The best combination was found to be a bicyclic substituent on one side of the compound, and a one‐ring moiety on the other side. Finally, the orientation of the central amide bond was found to have little effect on the biological activity. This study provides new insights in to the structure–activity relationships of SGI‐1027 and its derivative.
Near‐Field Hyperspectral Optical Imaging
Authors: Bouillard Jean‐Sebastien G. , Dickson Wayne , Wurtz Gregory A. , Zayats Anatoly V.
Published: February 2014

This Minireview presents an overview of near‐field hyperspectral imaging and discusses its applications. Based on a fibre‐tip probe, the hyperspectral near‐field optical microscope allows the simultaneous acquisition of near‐field images over a broad spectral range (400 to 1000 nm), enabling the recovery of local spectroscopic information, which is essential for understanding the resonant interaction of light with nanostructured objects because the far‐field and near‐field spectral responses can differ significantly, as is the case for plasmonic nanostructures. The optical information is collected through local interactions with the evanescent fields at the surface of the sample; therefore, the approach provides spectroscopic information with nanoscale spatial resolution. Several applications of spectroscopic near‐field microscopy are described for the visualisation of plasmonic modes in metallic nanostructures and near‐field fluorescence spectroscopy.
Optical Imaging of Liquid Crystals at the Nanoscale
Authors: Rosenblatt Charles
Published: February 2014

The instrumentation associated with near‐field scanning optical microscopy (NSOM) can be exploited to provide three‐dimensional structure and dynamic information about liquid crystals at scales not possible with diffraction‐limited tools. This Minireview focuses on our use of NSOM techniques to probe spatial variations of the nematic director and the nematic orientational order parameter on length scales as small as a few nanometers.
Reduced Dyes Enhance Single‐Molecule Localization Density for Live Superresolution Imaging
Authors: Carlini Lina , Benke Alexander , Reymond Luc , Lukinavičius Gražvydas , Manley Suliana
Published: February 2014

Cell‐permeable rhodamine dyes are reductively quenched by NaBH4 into a non‐fluorescent leuco‐rhodamine form. Quenching is reversible, and their fluorescence is recovered when the dyes are oxidized. In living cells, oxidation occurs spontaneously, and can result in up to ten‐fold higher densities of single molecule localizations, and more photons per localization as compared with unmodified dyes. These two parameters directly impact the achievable resolution, and we see a significant improvement in the quality of live‐cell point‐localization super‐resolution images taken with reduced dyes. These improvements carry over to increase the density of trajectories for single‐molecule tracking experiments.
Synthesis and Growth Mechanism of White‐Fungus‐Like Nickel Sulfide Microspheres, and Their Application in Polymer Composites with Enhanced Microwave‐Absorption Properties
Authors: He Shuai , Lu Chang , Wang Guang‐Sheng , Wang Jia‐Wei , Guo Hao‐Yue , Guo Lin
Published: February 2014

White‐fungus‐like NiSx microspheres have been synthesized on a large scale by using a simple hydrothermal method. The influence of the reaction time and the surfactant on the final products was investigated, and the formation mechanism was discussed. The synthesized white‐fungus‐like NiSx microspheres were used firstly as fillers in the fabrication of NiSx/polyvinylidene fluoride (PVDF) composites. Relationships between the loadings of the NiSx and wave‐absorption properties of the composites were analyzed. The loss mechanisms of NiSx/PVDF with different loadings were also discussed according to their dielectric and magnetic behaviors.
Anodic Nanotubular/porous Hematite Photoanode for Solar Water Splitting: Substantial Effect of Iron Substrate Purity
Authors: Lee Chong‐Yong , Wang Lei , Kado Yuya , Killian Manuela S. , Schmuki Patrik
Published: February 2014

Anodization of iron substrates is one of the most simple and effective ways to fabricate nanotubular (and porous) structures that could be directly used as a photoanode for solar water splitting. Up to now, all studies in this field focused on achieving a better geometry of the hematite nanostructures for a higher efficiency. The present study, however, highlights that the purity of the iron substrate used for any anodic‐hematite‐formation approach is extremely important in view of the water‐splitting performance. Herein, anodic self‐organized oxide morphologies (nanotubular and nanoporous) are grown on different iron substrates under a range of anodization conditions, including elevated temperatures and anodization supported by ultrasonication. Substrate purity has not only a significant effect on oxide‐layer growth rate and tube morphology, but also gives rise to a ninefold increase in the photoelectrochemical water‐splitting performance (0.250 vs. 0.028 mA cm−2 at 1.40 V vs. reversible hydrogen electrode under AM 1.5 100 mW cm−2 illumination) for 99.99 % versus 99.5 % purity iron substrates of similar oxide geometry. Elemental analysis and model alloys show that particularly manganese impurities have a strong detrimental effect on the water‐splitting performance.
Facet‐Dependent Photocatalytic Properties of TiO2‐Based Composites for Energy Conversion and Environmental Remediation
Authors: Ong Wee‐Jun , Tan Lling‐Lling , Chai Siang‐Piao , Yong Siek‐Ting , Mohamed Abdul Rahman
Published: February 2014

Titanium dioxide (TiO2) is one of the most widely investigated metal oxides because of its extraordinary surface, electronic, and photocatalytic properties. However, the large band gap of TiO2 and the considerable recombination of photogenerated electron–hole pairs limit its photocatalytic efficiency. Therefore, research attention is being increasingly directed towards engineering the surface structure of TiO2 on the atomic level (namely morphological control of {001} facets on the micro‐ and nanoscale) to fine‐tune its physicochemical properties; this could ultimately lead to the optimization of selectivity and reactivity. This Review encompasses the fundamental principles to enhance the photocatalytic activity by using highly reactive {001}‐faceted TiO2‐based composites. The current progress of such composites, with particular emphasis on the photodegradation of pollutants and photocatalytic water splitting for hydrogen generation, is also discussed. The progresses made are thoroughly examined for achieving remarkable photocatalytic performances, with additional insights with regard to charge transfer. Finally, a summary and some perspectives on the challenges and new research directions for future exploitation in this emerging frontier are provided, which hopefully would allow for harnessing the outstanding structural and electronic properties of {001} facets for various energy‐ and environmental‐related applications.
In situ synthesis of Nanocomposite Membranes: Comprehensive Improvement Strategy for Direct Methanol Fuel Cells
Authors: Rao Siyuan , Xiu Ruijie , Si Jiangju , Lu Shanfu , Yang Meng , Xiang Yan
Published: February 2014

In situ synthesis is a powerful approach to control nanoparticle formation and consequently confers extraordinary properties upon composite membranes relative to conventional doping methods. Herein, uniform nanoparticles of cesium hydrogen salts of phosphotungstic acid (CsPW) are controllably synthesized in situ in Nafion to form CsPW–Nafion nanocomposite membranes with both improved proton conductivity and methanol‐crossover suppression. A 101.3 % increase of maximum power density has been achieved relative to pristine Nafion in a direct methanol fuel cell (DMFC), indicating a potential pathway for large‐scale fabrication of DMFC alternative membranes.
Formfaktoren für Mauersteine
Authors: Brameshuber Wolfgang , Graubohm Markus
Published: February 2014

Bei der Druckfestigkeitsprüfung von Mauersteinen ist die Höhe des Prüfwertes von verschiedenen Faktoren abhängig. So kann u. a. die während der Druckbelastung hervorgerufene Querdehnungsbehinderung den Prüfwert der Druckfestigkeit deutlich beeinflussen. Wie groß dieser Einfluss ist, hängt im Wesentlichen von der Schlankheit der Mauersteine ab. Mit abnehmender Schlankheit vergrößert sich der Prüfwert der Druckfestigkeit durch den Einfluss der Querdehnungsbehinderung. Bei gleichem Mauersteinmaterial ergeben sich somit für Mauersteine mit geringer Schlankheit deutlich höhere Druckfestigkeitswerte als für Mauersteine mit größerer Schlankheit. Als weitere Einflussfaktoren können der Feuchtegehalt und das Größenformat der Prüfkörper genannt werden. Ziel einer am Institut für Bauforschung (ibac) der RWTH Aachen University durchgeführten Forschungsarbeit war die voneinander losgelöste Herleitung von differenzierten Formfaktoren für die zuvor genannten Einflussfaktoren. Untersucht wurden Prüfkörper mit unterschiedlichen Schlankheiten, Feuchtegehalten und Formaten, die aus Porenbeton‐Planelementen der Festigkeitsklassen 2 und 6 sowie Kalksandstein‐Planelementen der Festigkeitsklasse 20 entnommen wurden. Die Ergebnisse dieser Untersuchungen werden im vorliegenden Artikel vorgestellt.

Shape factors for masonry units. In compressive tests on masonry units, the height of the test value depends on different factors. Among others, the effect of platen restraint occurring during compression may exert a significant influence on the test value of the compressive strength. The extent of this influence mainly depends on the slenderness of the masonry units. The test value of the compressive strength increases with decreasing slenderness due to the influence exerted by the effect of platen restraint. Thus, when the masonry units are made of the same material, masonry units with a low slenderness yield significantly higher compressive strength values than masonry units with a high slenderness. Further influencing factors are the moisture content and the dimensions of the test specimens. It was the aim of a research project conducted at the Institute of Building Materials research (ibac) of RWTH Aachen University to separately derive defined shape factors for the previously mentioned influencing factors. Test specimens with different ratios of slenderness, moisture contents and dimensions which were taken from autoclaved aerated concrete high precision elements of strength classes 2 and 6 as well as from calcium silicate high precision elements of strength class 20 were examined. The results of these investigations are presented in the present paper.
Risk of disordered eating attitudes among male adolescents in five Emirates of the United Arab Emirates
Authors: Musaiger Abdulrahman O. , Al‐Mannai Mariam , Al‐Lalla Osama
Published: February 2014

Objective

The aim of this study was to highlight the prevalence of disordered eating attitudes among male adolescents in the United Arab Emirates (UAE).

Method

A multistage stratified sampling method was used to select 731 male students aged 15–18 years from five Emirates of the UAE. The Eating Attitudes Test (EAT‐26) was used to determine the prevalence of disordered eating attitudes in students.

Results

The findings revealed that the proportion of disordered eating attitudes in the UAE was relatively high compared with many developing and developed countries and ranged from 33.1% to 49.1%. Moreover, students living in the Emirates of Dubai and Al‐Fujairah have double the risk of having disordered eating attitudes compared with students living in the other Emirates.

Discussion

The results suggest the need for screening adolescents for eating disorders, as well as for increased awareness and understanding of eating disorders and their associated risk factors in all male adolescents in the UAE. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:898–900)
Electrochemical and Photoelectrochemical Sensing of NADH and Ethanol Based on Immobilization of Electrogenerated Chlorpromazine Sulfoxide onto Graphene‐CdS Quantum Dot/Ionic Liquid Nanocomposite
Authors: Jafari Fereydoon , Salimi Abdollah , Navaee Aso
Published: February 2014

Here, a simple one‐step solvothermal procedure was employed to synthesize a nanocomposite containing graphene‐nanosheets and CdS quantum dots (GNs‐CdS QDs). The electrochemical oxidation of chlorpromazine (CPZ) to chlorpromazine‐sulfoxide (CPZ‐SO) onto a GNs‐CdS QDs/ionic liquid (IL) nanocomposite modified glassy carbon (GC) electrode give rise to redox‐active products which showed excellent electrocatalytic and photoelectrocatalytic activity toward NADH oxidation at reduced overpotential. A linear response up to 200 µM was obtained for photoamperometric determination of NADH with detection limit 1 µM. Immobilizing alcohol dehydrogenase(ADH) onto the modified electrode via a simple cross linking procedure, the photoelectrochemical capability of the proposed system toward ethanol biosensing was clearly shown.
Point‐of‐Care Amperometric Testing of Diabetic Marker (HbA1c) Using Specific Electroactive Antibodies
Authors: Chopra Adity , Rawat Sanjay , Bhalla Vijayender , Suri C. Raman
Published: February 2014

Specific immune detection of glycated hemoglobin is still a great challenge owing to the small epitopic difference between Hemoglobin (Hb) and HbA1c. We report a new electrochemical immunoassay format for point of care testing of HbA1c. A conducting self‐assembled monolayer of mercaptophenyl boronic acid (MPBA) was used as a capture layer for binding of glycated proteins and ferrocene tagged anti‐HbA1c antibody (FcAb) as a tracer molecule on a gold screen printed electrode. Validation of the new HbA1c assay was carried out using 6 clinical samples with known HPLC values and a correlation coefficient of 98 % was observed.
Removal of alkali in the red mud by SO2 and simulated flue gas under mild conditions
Authors: Wang Xinke , Zhang Yihe , Lv Fengzhu , An Qi , Lu Rongrong , Hu Pan , Jiang Shaobin
Published: February 2014

In the present work, SO2 and SO2‐based dealkalization agents (SO2+N2 and SO2+CO2+N2), which were the simulated flue gases, were used to remove the alkali in red mud (RM) for wide applications of RM. Effects of reaction time, temperature, solid to liquid ratio, and SO2 concentration on dealkalization of RM were studied. Under the optimized conditions, the residue Na2O in RM after dealkalization could decrease to below 1 wt % no matter which simulated flue gas is used. But, as SO2+CO2 +N2 is used to remove Na2O in RM, longer time is needed due to the decreased SO2 concentration in the simulated flue gas. X‐ray diffraction (XRD), scanning electron microscope (SEM), and zeta potential were used to ascertain the change of RM before and after dealkalization. The results indicated that the structure of hydroxysodalite (Na8Al6Si6O24(OH)2) in the initial RM were destroyed and soluble sodium salts formed in the suspension which can be easily neutralized by acidic gas and then contributed to the decrease of Na2O in RM. The residue components in RM after dealkalization by SO2, and SO2‐based dealkalization agents are mostly SiO2, Fe2O3, and AlOOH. © 2014 American Institute of Chemical Engineers Environ Prog, 34: 81–87, 2015
Assessing the Tearing Energy of a Hydrocarbon Elastomeric Seal Material for Fuel Cell Applications
Authors: Klein Justin E. , Singh Hitendra K. , Divoux Gilles M. , Case Scott W. , Dillard David A. , Dillard John G. , Moore Robert B. , Parsons Jason B.
Published: February 2014

Elastomeric gaskets are commonly used between cells within a fuel cell stack to ensure that the reactant gases are isolated. Failure of a fuel cell gasket can cause the reactant gases to mix and can lead to failure of the fuel cell. An investigation of the durability of a hydrocarbon elastomeric seal material developed for proton exchange membrane fuel cells was performed by comparing the tearing energy required for crack propagation of as‐received and environmentally aged samples. Tear force was recorded as a function of crosshead displacement rate and the critical strain energy release rate was calculated and plotted against crack growth rate. Data obtained at different temperatures were then used to generate a fracture energy master curve. Additional samples were aged in selected relevant environments and compared to the as‐received material to study the effect of environmental aging on tear energy master curves. Comparison of tearing energy master curves for different test conditions showed an increase in the tearing energy for all aging environments. The tear energy master curve for testing carried out in water suggested that the crack propagation rates as low as of 10–8 ms–1 can be seen as the fracture energy approaches 80 Jm–2.
Distance Measurements to Metal Ions and Other Quadrupolar Spins by Magic Angle Spinning Solid State NMR
Authors: Goldbourt Amir
Published: February 2014

The characterization of metal sites in many types of materials is essential for understanding many aspects of chemistry and biochemistry, such as catalysis, enzymatic activity, and coordination. Of the many approaches to study such sites, this review deals with the utilization of dipolar recoupling in the context of magic angle spinning solid state NMR for qualitative and, in particular, quantitative distance measurements between metals and other quadrupolar nuclei to their surrounding environment. It will focus on the development of techniques, on their applicability towards experimental realizations, on key applications to materials and biological systems, and on current challenges and limitations.
Topical Developments in High‐Field Dynamic Nuclear Polarization
Authors: Michaelis Vladimir K. , Ong Ta‐Chung , Kiesewetter Matthew K. , Frantz Derik K. , Walish Joseph J. , Ravera Enrico , Luchinat Claudio , Swager Timothy M. , Griffin Robert G.
Published: February 2014

We report our recent efforts directed at improving high‐field dynamic nuclear polarization (DNP) experiments. We investigated a series of thiourea nitroxide radicals and the associated DNP enhancements ranging from ε=25 to 82, which demonstrate the impact of molecular structure on performance. We directly polarized low‐gamma nuclei, including 13C, 2H, and 17O, by the cross effect mechanism using trityl radicals as a polarization agent. We discuss a variety of sample preparation techniques for DNP with emphasis on the benefits of methods that do not use a glass‐forming cryoprotecting matrix. Lastly, we describe a corrugated waveguide for use in a 700 MHz/460 GHz DNP system that improves microwave delivery and increases enhancements up to 50 %.
First‐Year Students' Environmental Awareness and Understanding of Environmental Sustainability Through a Life Cycle Assessment Module
Authors: Weber Nicole R. , Strobel Johannes , Dyehouse Melissa A. , Harris Constance , David Ray , Fang Jun , Hua Inez
Published: February 2014

Background

Incorporating environmental sustainability (ES) into engineering education is vital to both individual engineering students' success and to the profession as a whole. This study explores attitudes, conceptions, and misconceptions about ES that students bring to the classroom. A promising framework of design‐based research is applied to gauge how instructional innovation can impact student attitudes, conceptions, and misconceptions.

Purpose

Two questions guided this research: What knowledge and attitudes about ES, particularly those pertaining to engineering, do first‐year engineering students have? How can an engineering module focused on life cycle assessment in a first‐year engineering course affect students' conceptual understanding to prepare them to develop a robust appreciation of environmental issues and ES in engineering?

Design/Method

A quantitative research design in the context of a comparative design‐based research study was utilized to examine first‐year engineering students' environmental awareness coming into the program and changes in their conceptions of ES following their participation in a module that focused on life cycle assessment (LCA).

Results/Conclusion

Following the participation in the LCA module, the intervention was able to address certain misconceptions and support students' shift to deeper understanding about ES. Students' perceptions regarding the complexity of LCA did not change. Including multifaceted issues such as LCA in the teaching of engineering students seems beneficial.