bluuebunny/crossref_metadata_2025 huggingface dataset:
Repurposing Pathogenic Variants of DMD Gene and its Isoforms for DMD Exon Skipping Intervention
Authors: Tyagi Rahul , Kumar Sumit , Dalal Ashwin , Mohammed Faruq , Mohanty Manju , Kaur Paramvir , Anand Akshay
Published: November 2019

Background:

Duchenne Muscular Dystrophy (DMD) is a progressive, fatal neuromuscular
disorder caused by mutations in the DMD gene. Emerging antisense oligomer based exon skipping
therapy provides hope for the restoration of the reading frame.

Objectives:

Population-based DMD mutation database may enable exon skipping to be used for the benefit
of patients. Hence, we planned this study to identify DMD gene variants in North Indian DMD cases.

Methods:

A total of 100 DMD cases were recruited and Multiplex ligation-dependent probe amplification
(MLPA) analysis was performed to obtain the deletion and duplication profile.

Results:

Copy number variations (deletion/duplication) were found in 80.85% of unrelated DMD
cases. Sixty-eight percent of cases were found to have variations in the distal hotspot region (Exon 45-
55) of the DMD gene. Exon 44/45 variations were found to be the most prominent among single exon
variations, whereas exon 49/50 was found to be the most frequently mutated locations in single/
multiple exon variations. As per Leiden databases, 86.84% cases harboured out-of-frame mutations.
Domain wise investigation revealed that 68% of mutations were localized in the region of spectrin
repeats. Dp140 isoform was predicted to be absent in 62/76 (81.57%) cases. A total of 45/80
(56.25 %) and 23/80 (28.70%) DMD subjects were predicted to be amenable to exon 51 and exon 45
skipping trials, respectively.

Conclusion:

A major proportion of DMD subjects (80%) could be diagnosed by the MLPA technique.
The data generated from our study may be beneficial for strengthening of mutation database in the
North Indian population.
Identification of Two Novel Mutations in the ATM Gene from Patients with Ataxia-Telangiectasia by Whole Exome Sequencing
Authors: Heidari Masoud , Soleyman-Nejad Morteza , Taskhiri Mohammad H. , Shahpouri Javad , Isazadeh Alireza , Ahangari Roghayyeh , Mohamadi Ali R. , Ebrahimi Masoumeh , Karimi Hadi , Bolhassani Manzar , Karimi Zahra , Heidari Mansour
Published: November 2019

Background:

Ataxia telangiectasia (AT) is one of the most common autosomal recessive
hereditary ataxia presenting in childhood. The responsible gene for AT designated ATM (AT, mutated)
encodes a protein which is involved in cell cycle checkpoints and other responses to genotoxicity.
We describe two novel disease-causing mutations in two unrelated Iranian families with Ataxiatelangiectasia.

Methods:

The probands including a 6-year-old female and an 18-year-old boy were diagnosed with
Ataxia-telangiectasia among two different Iranian families. In this study, Whole-Exome Sequencing
(WES) was employed for the detection of genetic changes in probands. The analysis of the cosegregation
of the variants with the disease in families was conducted using PCR direct sequencing.

Results:

Two novel frameshift mutations, (c.4236_4236del p. Pro1412fs) and (c.8907T>G p.
Tyr2969Ter) in the ataxia telangiectasia mutated ATM gene were detected using Whole-Exome Sequencing
(WES) in the probands. These mutations were observed in two separate A-T families.

Conclusion:

Next-generation sequencing successfully identified the causative mutation in families with
ataxia-telangiectasia. These novel mutations in the ATM gene reported in the present study could assist
genetic counseling, Preimplantation Genetic Diagnosis (PGD) and prenatal diagnosis (PND) of AT.
Predictors of Dental Students' Anticipated Willingness to Treat Underserved Populations Five Years After Graduation
Authors: Lu Sheng Hao , McQuistan Michelle R. , Qian Fang
Published: November 2019

The aim of this study was to assess which variables were associated with dental students' anticipated willingness to treat 13 underserved populations as dentists five years after graduation. A questionnaire was distributed from 2008 to 2014 to all 240 first‐ through fourth‐year dental students at the University of Iowa College of Dentistry & Dental Clinics. Only participants who completed surveys in each of their four years (n=132) were included in data analysis. The results showed that professional and personal interactions with each population, along with feeling comfortable and competent in treating a population, were most often associated with the students' anticipated willingness to treat underserved populations. In contrast, the participants' personal and demographic variables were less frequently associated with an anticipated willingness to treat underserved populations. In addition, shadowing a dentist before dental school and volunteering, either before or during dental school, were rarely associated with participants' anticipated willingness to treat underserved populations. These findings suggest that providing dental students with multiple positive opportunities to treat underserved populations may help them become more willing to treat underserved populations after they graduate.
Telecollaboration and genres: a new perspective to understand language learning
Authors: Rampazzo Laura , Aranha Solange
Published: November 2019

The purpose of this paper is to investigate the first 15 minutes of ten initial Teletandem Oral Sessions (iTOS), which means the first virtual encounter among speakers of different languages who want to study the each other’s language. Our aim is to verify iTOS genre status within a telecollaborative learning environment. We understand genres as communicative events organized in standard structures used by members of a discourse community to achieve their communicative purposes (Swales, 1990) and assume that the teletandem context is composed of a specific community with shared objectives. A study of iTOS had first been proposed by Aranha (2014), who analyzed nine iTOS and identified some recurrence in their discoursal structure. Our data, ten iTOS, are part of a previous version of MulTeC (Multimodal Teletandem Corpus) (Aranha & Lopes, forthcoming) and participants are proficient in Portuguese and English. The video files were transcribed and the sessions were analyzed based on Aranha’s (2014) findings. We identified rhetorical organization for the sessions which was similar to Aranha’s, but varied depending on the learning scenarios, i.e. the learning context in which they occurred.
Physical properties of four ring-porous hardwood species: influence of wood rays on tangential and radial wood shrinkage
Authors: Elaieb Mohamed Tahar , Shel Foued , Jalleli Mounir , Langbour Patrick , Candelier Kévin
Published: November 2019

Some relationships between ray proportions, strength and shrinkage properties and basic density in hardwood species were highlighted. A better understanding of their relationships caused by the variation in moisture content in the hygroscopic domain could be a key factor in determining of wood stability properties and to determine the choice of a specific wood species according to its service life condition. The objectives of this study were (i) to determine the physical properties of various ring porous wood species (ii) and to evaluate the influence of wood rays (according to their proportions and volume) on physical properties of wood and more particularly on the Transverse Anisotropy Ratio for Shrinkage (TARS). This study focused on four ring-porous hardwood species; Castanea sativa, Quercus canariensis, Quercus petraea and Quercus robur, differing by the presence and abundance of their multiseriate wood rays. Basic densities, tangential shrinkages, radial shrinkages and the TARS of heartwood and sapwood from each wood species were determined. Wood-rays’ proportions and volume were measured by the image analysis method, and their influence on the last three shrinkages was investigated. A significant correlation between wood ray proportions, wood shrinkage values and basic density was observed.
Development of the traditional digital games for strengthening childhood’s verbal skill
Authors: Majid Nuur Wachid Abdul , Ridwan Taufik
Published: November 2019

The aims of this research was to: (1) know the portability aspect of the Traditional Digital Games application as a medium for early childhood learning; and (2) know the usability aspect of the Traditional Digital Games applications as a medium for early childhood learning. The method used in this study is Research and Development (R & D). The stages through which the waterfall will be useful to be able to produce reliable and effective software. The waterfall flowchart consists of: analysis, design, implementation, testing, and improvement. The results of this study were: (1) the results of testing from the portability aspect using a different smartphone, it can be concluded that traditional digital game applications have entered into a very good category; and (2) the results of testing usability aspects averaged over 70%, so that in both aspects the test was considered feasible and good. Although in the aspect of learning games the score shows 70.83% so it needs an increase.
Collaborative, Capacity Development Efforts: A case of Kampung Hujung Rintis, Perak and UiTM Cawangan Selangor, Malaysia
Authors: Hashim Rugayah , Mohd Aminuddin Zaidi , Ghazali Ayu Rohaidah , Abd Razak Norfadzilah
Published: November 2019

Public universities have been directed to have more collaborative projects with disadvantaged communities for capacity and sustainable developments. In the case of Universiti Teknologi MARA, Selangor Branch (UCS), the success stories on community engagement and capacity development have been shown with Kampung Hujung Rintis, Perak, Malaysia. This paper aims to showcase impacts on collaborative efforts through a live research laboratory for data collection using multiple techniques. The feedbacks from cross-disciplinary projects were for the implementation of capacity-development initiatives at Kampung Hujung Rintis. The implications from the case events showed that continuous community engagements would be beneficial for all parties involved.Keywords: Capacity Development; Disadvantage Communities; Research Co-production; Sustainable DevelopmenteISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1751
Discovering Distinctive Street Patterns of Snatch Theft through Crime Prevention through Environmental Design
Authors: Md Sakip Siti Rasidah
Published: November 2019

The theft crime rate in Malaysia for 2010 and 2015 is experiencing an increase in the rate of decline. This high-crime activity depends on an opportunity to commit a crime at the time of the incident. Thus, this paper is aimed at discovering distinctive street patterns of snatch theft through crime prevention through environmental design (CPTED). This research is a qualitative approach by field observation to investigate the physical environment of the snatch theft hotspot area. The finding indicates the three main principles of CPTED, which are surveillance, access control and territoriality contributed to snatch theft crime incidence.Keywords: Snatch theft; Street; Environment setting; CPTEDeISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1891
Depression and Its Contributing Factors: A study among staff of an academic institution in Malaysia
Authors: Razali Salmi , Yung-An Chua , Mat Nazali Mohd Izwan , M Nawawi Hapizah
Published: November 2019

Information on depression and its contributing factors among the staff of the academic institution is sparse. Hence, this study aimed to determine the prevalence of depression among them and investigate its contributing factors. We used the Depression, Anxiety and Stress Scale 21-item and pro forma questionnaires to assess the presence of depression, sociodemographic factors, personal factors and job-related factors. Of 278 participants, 27.7% had clinical depression. Contributing factors include inadequate workplace facilities, low-tier job category, working in urban campus and low income. Addressing factors underpin depression among staff in the academic institution is crucial to ensure early interventions can be offered.Keywords: Depression; Academic Institution; Workers; Contributing FactorseISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1894
Micro Housing: Typological study and implementation in Malaysia
Authors: Kholid Mohd Fairus , Zaharin Puteri Mayang Bahjah
Published: November 2019

The micro-housing project introduced by Kuala Lumpur City Council (DBKL) has received cynical rumours amongst the B40 income group due to its impracticality, thus suggesting that micro-housing standard is misinterpreted and simplified. As such, this paper intends to investigate the potentiality of ideal micro-housing that is suitable for the Malaysian context, specifically for the B40 community. Based on a bottom-up approach, this research divides into the micro and macro study. In the micro-study, the focus is specifically on the typological design of micro-housing. Hence this leads to a macro context, which developed the typological analysis in regards to the regional cultural influence. In thoroughly, from seven (7) international precedents, micro-housing can be formulated into four main typologies that include Box, Mobile, Machine, and Props type. These typologies incline towards two (2) cultural domains, namely Possession Domesticity, which demonstrates Westerners influence through technological advancement and Transience Domesticity that portrays Orientalist influenced by the mixture of practicality and human psychology. These attributes tested in three (3) local micro-housing projects that consist of two prototypes by local architect and a built micro-housing project by DBKL. The result shows that both prototypes are potentially ideal. However, DBKL’s built project demonstrated a minimal standard of appropriate micro-housing living. It founds that the lack of axiological human needs may lead to a degradation of values and behaviour. Thus, it significantly recommends that the projects reconsider of adapting the psychological needs for the betterment of its user’s living.Keywords: micro-living, adaptable housing typology, regional cultural study, psychological needseISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1934
An Assessment on the Housing Auction Market in Selangor
Authors: Zainudin Farah Eleena , Mohamed Osman Mariana , Muhamad Yusop Siti Wahidah , Ibrahim Mansor
Published: November 2019

The first auction legislation in Malaysia was enacted in the states of Penang and Malacca in 1906. The real estate market including auction market  is considered  an effective method in selling real estate properties (Chyi, 2015). Auction is one method in selling property in a quick way but this method is consider as force sales as most properties sold due to owner unable to pay the monthly mortgage to the bank. There are advantages of buying property in auction market where the buyer can get the property cheaper than market value and the property usually has a matured environment. The downside of purchasing an auction property is that the buyer is not allowed to view or inspect the inside of the property and sometimes the property is not vacant by the owner.  The buyer need to conduct their own research first if they have the intention to buy auctioned property. Based on literatures, there are various considerations for buying auction properties such as the type of properties, the location, value, existing conditions, the existing facilities and infrastructure and many more. This aim of the study is to assess the issues and problems faced by buyers in housing auction market in Selangor. The objectives were to identify the preferred location among the respondents in selection their bidding units. It was found that among respondents, the most preferred location of auction properties was in Gombak. In term of issues and problem in buying auction properties, respondents claimed the issues are the long period of time in getting loan approved and released payment , the title and ownership issues, the units are still occupied by owner, the conditions of units and the overall cost that need to be prepare by buyers. It is hoped that this paper would guide decision maker and government in planning of the overall housing market in Malaysia as properties being auctioned is getting higher over time.Keywords: Auction, Purchaser, Property, SelangoreISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1935
Electronic Screening for Alcohol Use and Brief Intervention by Email for University Students: Reanalysis of Findings From a Randomized Controlled Trial Using a Bayesian Framework
Authors: Bendtsen Marcus
Published: November 2019

Background

Almost a decade ago, Sweden became the first country to implement a national system enabling student health care centers across all universities to routinely administer (via email) an electronic alcohol screening and brief intervention to their students. The Alcohol email assessment and feedback study dismantling effectiveness for university students (AMADEUS-1) trial aimed to assess the effect of the student health care centers’ routine practices by exploiting the lack of any standard timing for the email invitation and by masking trial participation from students. The original analyses adopted the conventional null hypothesis framework, and the results were consistently in the expected direction. However, since for some tests the P values did not pass the conventional .05 threshold, some of the analyses were necessarily inconclusive.

Objective

The outcomes of the AMADEUS-1 trial were derived from the first 3 items of the Alcohol Use Disorders Identification Test (AUDIT-C). The aim of this paper was to reanalyze the two primary outcomes of the AMADEUS-1 trial (AUDIT-C scores and prevalence of risky drinking), using the same models used in the original publication but applying a Bayesian inference framework and interpretation.

Methods

The same regression models used in the original analysis were employed in this reanalysis (linear and logistic regression). Model parameters were given uniform priors. Markov chain Monte Carlo was used for Bayesian inference, and posterior probabilities were calculated for prespecified thresholds of interest.

Results

Where the null hypothesis tests showed inconclusive results, the Bayesian analysis showed that offering an intervention at baseline was preferable compared to offering nothing. At follow-up, the probability of a lower AUDIT-C score among those who had been offered an intervention at baseline was greater than 95%, as was the case when comparing the prevalence of risky drinking.

Conclusions

The Bayesian analysis allows for a more consistent perspective of the data collected in the trial, since dichotomization of evidence is not looked for at some arbitrary threshold. Results are presented that represent the data collected in the trial rather than trying to make conclusions about the existence of a population effect. Thus, policy makers can think about the value of keeping the national system without having to navigate the treacherous landscape of statistical significance.

Trial Registration

ISRCTN Registry ISRCTN28328154; http://www.isrctn.com/ISRCTN28328154
Q-Switched Nd:YAG Laser Guidelines (Preprint)
Authors: Sakhiya Sr Jagdish , Gandhi Jr Suneil , Kaklotar Jr Jitesh , Purohit Jr Madhav , Banker Shailee , Daruwala Jr Feral , Dudhatra 2nd Nimish , Sakhiys Dhruv
Published: November 2019

UNSTRUCTURED

The Q‑switched Nd:YAG laser is an established modality of treatment for epidermal and dermal pigmented lesions, tattoo removal and acne. The dual wavelengths of 1064nm and 532nm are suited for the darker skin tones encountered in India. Despite having treated several indications with Q‐switched Nd:YAG laser, its detailed guidelines have not been reported to date. This article highlights the basics of Q‑switched Nd:YAG laser and its detailed guidelines.
Nanofotónica. Los grandes avances y retos de un mundo pequeño
Authors: Coello Víctor
Published: November 2019

Se presenta una panorámica general del desarrollo de la nanofotónica a nivel global. Se exponen los desarrollos pioneros y los problemas que los mismos enfrentaron. También se comentan de manera general las tendencias actuales y se describe cuáles son los principales motivos que impiden un desarrollo terminado y cuáles son las estrategias para superarlos. Finalmente, se muestra de manera descriptiva la situación actual de esta área en México.
The Periodic Table: Icon and Inspiration
Authors: Poliakof Martyn
Published: November 2019

Since Dmitry Mendeleev published the initial concept of the Periodic Law in 1869, the Table has been continuously updated with newly discovered elements, and figuratively speaking, today it serves both as an icon and as an inspiration for modern chemists. Its image is so easily recognizable all around the world that it has become a symbol for science. This paper highlights just a few of the varied forms that the Table can take, such as an infographic, which can convey the shortage of certain elements with great impact.
Stars from Craddle to Grave: Powerful Factories of Chemical Elements
Authors: Lutovinov Alexander A.
Published: November 2019

The first elements of the Periodic Table – hydrogen, helium and partly lithium - appeared in the first seconds after the birth of the Universe. The first stars “gathered” from these materials are the natural factories of the synthesis of heavier elements, not only throughout their lives, but even during their death process, during Supernova explosions. Supernova explosions, in their turn, are powerful factories for the production of heavy elements. Modern instruments allow scientists not only to register such events, but also to determine how many different chemical elements were formed during such events. The recent discovery of the merging neutron stars and subsequent studies of their afterglow allowed us to clarify the process of formation of superheavy elements in the Universe up to the gold and uranium. Thus, astrophysical observations give scientists the most important information about the “production rates” of elements in the nature, and their abundance in the Universe.
Application of Complexes of Group 13 Elements in Synthetic Organic Chemistry for Activation of Carbonyl Compounds
Authors: Novikov Roman A. , Tomilov Yury V.
Published: November 2019

The main aspects of modern organic chemistry of the Group 13 elements – aluminum (Al), gallium (Ga), indium (In), and thallium (Tl) – are considered. Herewith, the main emphasis is placed on their use for the various carbonyl compounds activation in organic synthesis and reactions, which are specific for these elements. The 21th century marked a new era in the development of chemistry of the Group 13 elements; it is connected with the discovery of surprising and unexpected reactions and new compounds (primarily in the area of organic and coordination chemistry), defining various fields of these elements application.
XX Mendeleev Congress on General and Applied Chemistry
Authors: Ponizovkin Andrey Yu.
Published: November 2019

A comprehensive report on the XX Mendeleev Congress on General and Applied Chemistry is presented. The most interesting reports are considered, among them are: presentation of Nobel Prize winner Professor D. Shechtman on quasi-periodical crystals; report of Professor S. Dmitriev about completing Mendeleev’s Periodic Table of chemical elements with super heavy elements (atomic numbers 113–118); lecture of then RAS President Academician V. Fortov on the behavior of chemical elements under extremal conditions of superhigh pressures where materials basically change their properties; presentation of Professor K. Ganesha on a new generation of peptide nucleic acids analogs capable of selectively binding DNA or RNA molecules; the combined report of Academicians O. Chupakhin and V. Charushin on the intensive entry of the nucleophilic functionalization of C–H bonds into the theory and practice of organic synthesis, and others. Possibilities of cooperation of fundamental science and leading industrial companies are discussed. Significant attention is given to the modern chemical education as well.
Elements of the Fifth Group of the Periodic System of D.I. Mendeleev – the Elements of Life
Authors: Gazizov Almir S. , Sadykova Yulia M. , Gibadullina Elmira M. , Burilov Alexander R. , Kibardina Lyudmila K. , Knyazeva Irina R. , Trifonov Alexey V. , Sinyashin Oleg G.
Published: November 2019

In the popular science review, dedicated to the 150th anniversary of the first publication of the Periodic Table of chemical elements by D.I. Mendeleev, the elements of the 5th (main) Group (namely nitrogen, phosphorus, arsenic, antimony, and bismuth) are considered. The history of these elements discovery and some their properties are shortly described. The elements of the fifth group are also called “the elements of life”, which is linked with both the development of living organisms themselves and their compounds importance for human life. The review confirms this thesis in a popular-science form, using the available literature data on the role of chemical compounds of Group 5th elements in the development of living nature as well as in the progress of human civilization.
Methods for Synthesis of Molecular Materials with Unique Physical Properties
Authors: Sidorov Alexey A. , Kiskin Mikhail A. , Baranchikov Alexander E. , Ivanov Vladimir K. , Eremenko Igor L.
Published: November 2019

The authors discovered and investigated new types of stable heterometallic carboxylate complexes in which divalent transition metal atoms of the 4th period of the Periodic Table of Chemical Elements (V, Co, Ni, Cu, Zn) combine with atoms of lithium, magnesium, calcium or rare earth elements. These polynuclear heterometallic compounds retain their structure under conditions when the homometallic compounds of these transition metals decompose to mononuclear complexes. The different metals combination in one molecule allows us to use the obtained heterometallic compounds for producing disperse and film oxide materials, and bimetallic oxide catalysts. The stability of the complexes allows to immobilize them in various matrices and to assemble 3D polymer structures on their base. Since the metal ions under consideration (V, Co, Ni, Cu, Zn) are capable to form isostructural heterometallic compounds, it becomes possible to obtain compounds within a single structural type with a given combination of physical properties, determined by the nature of the metal ions.
Economic Development-Based on Local Tourism in Yogyakarta
Authors: Asworo Listiana
Published: November 2019

Tourism sector has long been referred to as economic sector. It is believed that tourism is one of the factors causing multiplier effect that result in welfare on one side and community empowerement on another side. In order to realize the multiplier, effect all stakeholders should work in a synergy to develop tourism-based local economics. The article described how bottom-up approach, empowerement and local wisdom had given positive contribution towards tourism sector in Gua Pindul and at the same time improved the local economics.
Combustión sin llama como una alternativa para mejorar la eficiencia de sistemas térmicos: revisión del estado del arte
Authors: Yepes Hernando A. , Arrieta Carlos E. , Amell Andres A.
Published: November 2019

El aumento de la demanda energética, así como de las emisiones contaminantes ha generado un incremento de la investigación de tecnologías que permitan mitigar ambas problemáticas a nivel mundial. Dentro de las alternativas para mejorar la eficiencia de los procesos térmicos, el régimen de combustión sin llama se presenta como una de las alternativas más promisorias, puesto que permite obtener altos valores del rendimiento térmico mediante el mejoramiento de la transferencia de calor y del proceso de combustión, con la consiguiente reducción de las emisiones contaminantes. Debido a esto, en el presente estudio se realiza una revisión del estado del arte de dicha tecnología, haciendo énfasis en los aspectos fenomenológicos asociados, las principales características del régimen y su estabilidad, pasando por los mecanismos de obtención y la presentación de una serie de estudios, tanto a nivel nacional como internacional, en los que se utilizaron combustibles fósiles y alternativos. La revisión finaliza con la discusión de algunos casos en los cuales se ha implementado el régimen a nivel industrial.
Estimación del potencial fotovoltaico mediante minería de datos en cuatro ciudades de Colombia
Authors: Ramírez Murillo Universidad Santo Tomás , Torres-Pinzón Carlos A. , Forero-García Edwin F.
Published: November 2019

En este trabajo se analiza el potencial fotovoltaico en cuatro ciudades colombianas, gracias a la información recopilada en Bogotá, Cúcuta, Manizales y Pasto. La metodología propuesta utiliza técnicas de agrupamiento que se implementan mediante el uso del software MATLAB®. Se exponen dos algoritmos de comparación presentados: K-means y Fuzzy C-means, y uno de visualización que es el Análisis de componentes principales (PCA) que ayuda en el análisis de resultados. Este artículo muestra estudios previos relacionados con la minería de datos y se describen los algoritmos mencionados anteriormente. Por otro lado, los resultados y discusión más relevantes, que corresponden a la factibilidad de implementación de las micro-redes, se determinan mediante el cálculo del Factor de Capacidad.
Application of the Internet of Things through a Network of Wireless Sensors in a Coffee Crop for Monitoring and Control its Environmental Variables
Authors: Ruíz Martínez William , Díaz-Gutiérrez Yesid , Ferro-Escobar Roberto , Pallares Luis
Published: November 2019

This article presents the application of the Internet of things (IoT), as a technological tool for the development of a wireless sensor network with the aim of monitoring and controlling a series of environmental variables affecting the cultivation of coffee and its final quality. The logical and physical design of the network and its devices was carried out, the sensors network was configured in a given field and the information of certain environmental variables was collected to be compared with a series of parameters already established. This procedure will allow the coffee growers to observe the behavior of these variables over time and set the generation of alerts or warnings when these measures are outside the established ranges. The study determined that the management of coffee cultivation is quite complex due to the large number of varieties found, the terrain and environmental variables affecting the production process and the final quality of the grain. It was also determined that the development and implementation of wireless sensor networks is possible today due to factors such as the reduction of device costs and the use of open source software, avoiding additional licensing values. Finally, based on the parameters analyzed, it was possible to establish that one of the main problems in coffee crops is the intense humidity that, in practice, can affect the performance of the sensors and their measurements.
Quasi-Dynamic Analysis of a Local Distribution System with Distributed Generation. Study Case: The IEEE 13 Node System
Authors: Gaitán Luis Felipe , Gómez Juan David , Rivas-Trujillo Edwin
Published: November 2019

Distributed generation is one of the most accepted strategies to attend the increase in electrical demand around the world. Since 2014, Colombian government agencies have enacted laws and resolutions to promote and regulate the introduction of different generation technologies into the country’s electrical system. The incorporation of distributed generation systems into conventional distribution networks can cause problems if technical studies are not previously carried out to determine the consequences of the start of the operations of these new generation technologies. This scenario represents a new challenge for distribution networks operators because they must ensure that their systems can integrate these new generation sources without affecting the correct operation of the grid. In this article, the IEEE 13 nodes system is modified by incorporating the load curves of the three types of consumers in the Colombian electricity market into the model. Additionally, distributed generation systems from non-conventional sources of energy are integrated into two system nodes in order to perform a quasi-dynamic analysis of the different electrical variables, which can be used to determine the impact of these new technologies on a local distribution system. The voltage profiles and active and reactive power do not show considerable changes in the behavior of the electrical network; however, in the simulation scenarios where distributed generators are operating, the system exhibits a considerable increase in lines losses. There are two alternatives to manage these unusual levels in the operation of the nodes with distributed generation: (1) operating these new DG nodes in islanded mode or (2) strengthening the local distribution system through the implementation of new distribution lines in the network.
Development and Testing of a Real-Time LoRawan Sniffer Based on GNU-Radio
Authors: Bravo-Montoya Andrés F. , Rondón-Sanabria Jefersson S. , Gaona-García Elvis E.
Published: November 2019

This paper shows the vulnerabilities present in a wireless sensor network implemented over a long-range wide area network (LoRaWAN) LoRaWAN, and identifies possible attacks that could be made to the network using sniffing and/or replay. Attacks on the network were performed by implementing a protocol analyzer (Sniffer) to capture packets. The Sniffer was implemented using the RTL2832U hardware and visualized in Wireshark, through GNU-Radio. Tests showed that data availability and confidentiality could be threatened through replay attacks with LoRa server verification using HackRF One and GNU-Radio hardware. Although the LoRaWAN specification has, frame counters to avoid replay attacks, under given the right conditions, this measure could be violated even deny service to the node on the server.
Grade Inflation in the Family Medicine Clerkship
Authors: Schiel Kimberly Zoberi , Everard Kelly  M.
Published: November 2019

Background and Objectives: Medical educators perceive grade inflation to be a serious problem. There is some literature discussing the magnitude of the problem and ways to remediate it, but little literature is available in the field of family medicine. We sought to examine what methods of remediating grade inflation have been tried by family medicine clerkship directors, and what factors influence the chosen method of addressing this problem.
Methods: We conducted a national Council of Academic Family Medicine’s (CAFM) Educational Research Alliance (CERA) survey of family medicine clerkship directors, inquiring about their perceptions of the seriousness of grade inflation, whether it was perceived as a remediable problem, and what methods had been tried within the last 3 years to address this problem.
Results: The response rate was 69%. Clerkship directors’ perceptions that grade inflation is a serious problem either nationally or in their own clerkship did not correlate with how they weighted the objective versus subjective portions of the clerkship grade. Clerkship directors who agreed that grade inflation was a remediable problem had a higher percentage of nonexamination objective criteria and a lower percentage of subjective criteria in their grading formula. Clerkship directors who agreed grade inflation is a problem in their clerkship were more likely to have tried giving feedback to graders on grade distribution than those who didn’t think grade inflation was a problem.
Conclusions: Family medicine clerkship directors perceive grade inflation to be a serious problem, both at a national level and in their clerkships. Various methods of addressing grade inflation have been tried by family medicine clerkship directors.
UPAYA MENINGKATKAN KECERDASAN KINESTETIK MELALUI KEGIATAN MENARI LAGU TOKECANG
Authors: Nuraini Rini
Published: November 2019

Rini Niraini (2017).  Upaya Meningkatkan  Kecerdasan  Kinestetik Melalui  Kegiatan  Menari Lagu Tokecang (Penelitian Tindakan Kelas Terhadap Anak Usia Dini Kelompok B Di TK Permata Ibu Cimahi)Penelitian ini bertujuan untuk memperoleh gambaran kondisi objektif kecerdasan kinestetik anak pada kelompok B sebelum diterapkannya kegiatan menari lagu tokecang, memperoleh gambaran mengenai pelaksanaan kegiatan menari lagu tokecaang dalam meningkatkan kecerdasan kinestetik, memperoleh gambaran mengenai peningkatan kecerdasan kinestetik pada anak kelompok B setelah diterapkannya kegiatan menari.Penelitian ini menggunakan metode penelitian tindakan kelas (PTK), yang terdiri dari empat tahapan yaitu 1) Perencanaan, 2) Pelaksanaan Tindakan, 3) Observasi dan Evaluasi, 4) Refleksi. Subjek dalam penelitian ini berjumlah 13 orang anak. Tehnik pengumpulan data ini adalah wawancara, observasi, dan dokumentasi. Tehnik pengumpulan data yang dilakukan adalah deskriptif kuantitatif dengan mengunakan tehnik persentase dengan pelaksanaan beberapa tahapan..Kondisi awal kemampuan kinestetik di TK Permata Ibu Cimahi berada pada kategori berkembang sangat baik (BSB) hanya 8 % dari keseluruhan siswa. Namun setelah diberikan tindakan siklus I pencapaian kemampuan kinestetik anak pada kategori BSB meningkat menjadi 23 %, dan setelah diberikan tindakan siklus II pencapaian perkembangan kemampuan kinestetik anak meningkat kembali menjadi 85 % dari keseluruhan siswa.Berdasarkan hasil analisis dan pembahasan maka dapat disimpulkan bahwa kemampuan kecerdasan  kinestetik anak dapat ditingkatkan melalui kegiatan menari lagu tokecang, melalui kegiatan menari ini dapat menstimulasi kemampuan kecerdasan gerak tubuh, serta dapat mengekspresikan diri melalui gerakan menari yang bervariasi, dan mengekspresikan diri dalam gerkan.
MENINGKATKAN KEMAMPUAN PRA KEAKSARAAN ANAK USIA DINI KELOMPOK B MELALUI METODE BERNYANYI DI TK KARTIKA XIX-I
Authors: Sumini Nita , Yulianti Yulianti
Published: November 2019

Menyanyi adalah suatu kegiatan yang menarik serta dapat mengatasi rasa cemas dan memberikan relaksasi serta ketenangan bagi anak. Melalui nyanyian kegiatan pembelajaran akan terasa lebih menyenangkan. Untuk itu team peneliti berusaha mengetahui sejauh mana metode menyanyi dapat meningkatkan kemampuan bicara anak. Adapun  penelitian ini bertujuan: 1) Untuk mengetahui kemampuan awal pra keaksaraan anak usia dini. 2) mengetahui perencanaan metode bernyanyi. 3) Mengetahui proses pelaksanaan metode nyanyian. 4) Untuk mengetahui hasil pelaksanaan metode bernyanyi.Metode yang digunakan adalah Penelitian Tindakan Kelas (PTK). Penelitian ini dilakukan di salah satu Taman Kanak-Kanak yang berada di Kelurahan Sarijadi Kotamadya Bandung. Hasil penelitian diperoleh data mengenai 1) Proses pembelajaran bahasa yang efektif untuk mengembangkan kemampuan pra keaksaraan anak usia dini. 2) Dampak metode bernyanyi terhadap kemampuan pra keaksaraan anak. 3) Faktor-faktor yang mendukung dan menghambat kemampuan pra keaksaraan anak usia dini melalui metode bernyanyi.Rekomendasi penelitian ini diantaranya : 1) Bagi sekolah, perlunya penyediaan sarana prasarana yang digunakan untuk menunjang kemampuan pra keaksaraan anak usia dini. 2) Bagi Pendidik untuk mengetahui penggunaan metode bernyanyi dalam mengembangkan kemampuan pra keaksaraan anak usia dini. 3) Bagi Instansi Pembina, sebagai referensi tentang metode bernyanyi dalam  mengembangkan kemampuan pra keaksaraan anak usia dini. Dari hasil Penelitian Tindakan kelas ini dalam disimpulkan bahwa bernyanyi adalah suatu metode yang bisa digunakan untuk meningkatkan kemampuan pra keaksaraan anak usia dini.
UPAYA PENGEMBANGAN DISIPLIN ANAK DENGAN METODE PEMBIASAAN PEMBERIAN KALUNG ANGKA PADA KELOMPOK B3 DI RA AL-JIHAD PADALARANG
Authors: Nurmala Mega
Published: November 2019

Penelitian ini dilakukan berdasarkan temuan masalah yang terkait dengan kedisiplinan anak pada kelompok B3 di RA Al-Jihad Padalarang. Berdasarka observasi awal menunjukan rendahnya kedisiplinan anak seperti: terlambat datang ke sekolah, berebut tempat saat berbaris, saling mendahului saat mengantri, membiarkan sepatu di halaman, dan berebut tempat penyimpanan tas. Berdasarkan hal tersebut, yang menjadi tujuan dari penelitian ini adalah mengetahui bagaimana perencanaan, pelaksanaan dan evaluasi pengembangan disiplin anak melalui metode pembiasaan pemberian kalung angka. Metode penelitian yang digunakan adalah deskriptif, berbentuk kualitatif. Subjek penelitian ini adalah anak kelompok B3. Teknik dan alat pengumpulan data menggunakan teknik wawancara, observasi, studi dokumentasi dan studi literatur. Dari data yang diperoleh diketahui bahwa metode pembiasaan pemberian kalung angka dalam mengembangkan disiplin anak pada kelompok B3 di RA Al-Jihad Padalarang, sangat efektif serta dikembangkan dan diterapkan dengan baik, konsisten dan konsekuen sehingga kedisiplinan anak berkembang sesuai dengan yang diharapkan. Pengembangan disiplin melalui metode pembiasaan pemberian kalung angka dilakukan setiap hari, setiap anak tiba di sekolah, dan dapat digunakan dalam  kegiatan sehari-hari baik di dalam kelas maupun diluar kelas dan menggunakan indikator capaian perkembangan yang ada pada teori-teori kedisiplinan anak usia dini.
PEMBENTUKAN KARAKTER MANDIRI PADA ANAK USIA DINI MELALUI METODE MONTESSORI DI TK ALMARHAMAH CIMAHI
Authors: Sunarti Cucu , Uwie Wiwin , Sumitra Agus
Published: November 2019

This journal was to give knowledge for early childhood tutors about learning strategies to improve the emotion social of children abilities. When the learning strategy used by an early childhood tutors was effective, so the achievement level of emotional social intelligence will be maximized and child will grow into a child of character. Character is the key of individual success. It means that someone activity an life wants to succeed, so the absolute requirement must be supported by a strong character capacity. The high character qualities of the community will foster a strong desire to improve the nation quality. In early childhood emotional social development, several assessment reference of early childhood tutor will find it easier to assess and measure the emotional social of children abilities. Learning strategies that are not commonly known by early childhood tutors are learning strategies with Montessori method. Learning with Montessori methode caracter development designed the freedom to think, work and do something.
IMPROVING CHILDREN'S LABOR CHILDREN A THROUGH THE APPLICATION OF METODECANTOL ROUDHOH IN NURDZAKKY KIND OF DISTRICT CISARUA DISTRICT BANDUNG BARAT
Authors: Rohaeti Rohaeti
Published: November 2019

Research on improving the language ability of the children of Group A in Nurdzakky kindergarten, backed by less optimal child's language skills, and to know the planning of language ability improvement, learning process of cantol roudhoh method, and improvement of language ability after applying cantol roudhoh method using data collection technique observation, interview, and documentation. The subject of research is pre-school children kindergarten Nurdzakky, District Cisarua, West Bandung regency. Child language skills development data is collected through observation and field notes. Data analysis was done by descriptive analysis with result as follows, objective condition of development of language ability of child in Nurdzakky kindergarten, showed the ability of child language at the beginning of learning has not developed optimally, seen still less understanding story, mention syllable, mention words well, imitate mentioning sentences, imitating writing. The ability of the language of children shows only three (3) children out of ten (10) children who begin to develop, while as many as seven (7) children are still not developed, after the learning process by applying the cantol roudhoh method there are five (5) , four (4) children begin to develop, and one (1) children not yet developed, towards the end of semester 2 the development of children's language increased to seven (7) children have developed as expected, even there are two (2) children who develop very well, and one (1) developing child. The existence of a significant influence so that it can be argued that through learning methods of reading cantol roudhoh, can improve the language skills of children in kindergarten Nurdzakky.
OPTIMALISASI PENDIDIKAN ANAK USIA DINI BERDASARKAN PEMBELAJARAN YANG BERBASIS PERKEMBANGAN OTAK
Authors: Azizah Siti Raf'ah , Arofah Nopika Dwi , Sumitra Agus
Published: November 2019

Brain-based learning is a comprehensive approach to instruction based on how current neuro-science research shows our brains learn naturally, that brain-based learning is a learning approach that emphasizes the best natural principles available in the operation of the brain, with the aim of achieving maximum attention, understanding, meaning, and memory. These base learning begins with what is known about the actual structure and use of human thought at various stages of development. Based on the previous explanation, the research conducted by Hazhira Qudsyi (please include the year and write in the bibliography) concludes about learning strategies that can optimize education in early childhood, namely through brain-based learning, because early childhood education (PAUD) is a very basic and strategic education, as the initial foundation for the growth and development of the next child. This research was conducted with qualitative research methods to understand the phenomenon. Based on these results, it was found that optimizing the learning process in early childhood education has its own challenges, especially with the typical characteristics possessed by students, namely early childhood. This article was written with the aim of studying brain-based learning as an effort to optimize early childhood education.