bluuebunny/crossref_metadata_2025 huggingface dataset:
AMPLITUDE: A study of niraparib in combination with abiraterone acetate plus prednisone (AAP) versus AAP for the treatment of patients with deleterious germline or somatic homologous recombination repair (HRR) gene-altered metastatic castration-sensitive prostate cancer (mCSPC).
Authors: Rathkopf Dana E. , Chi Kim N. , Olmos David , Cheng Heather H. , Agarwal Neeraj , Graff Julie N , Sandhu Shahneen Kaur , Hayreh Vinny , Lopez-Gitlitz Angela , Francis Peter St. John , Attard Gerhardt
Published: March 2021

TPS176

Background: Clinical benefit has been observed with poly(ADP-ribose) polymerase (PARP) inhibition in patients with metastatic castration-resistant prostate cancer tumors that carry HRR gene defects. Niraparib is a highly selective and potent PARP inhibitor, with activity against PARP-1 and PARP-2 deoxyribonucleic acid (DNA)-repair polymerases. The objective of AMPLITUDE is to assess the efficacy and safety of niraparib/placebo added to AAP with androgen deprivation therapy (ADT) in a biomarker-selected population with mCSPC. Methods: AMPLITUDE (NCT04497844) is a phase 3, randomized, double-blind, placebo-controlled study with an expected enrollment of 788 patients at ~350 sites in ~30 countries. Clinical trial information: NCT04497844. [Table: see text]
Uncertainty and complementarity relations based on generalized skew information
Authors: Huang Huaijing , Wu Zhaoqi , Fei Shao-Ming
Published: March 2021

Uncertainty relations and complementarity relations are core issues in quantum mechanics and quantum information theory. By use of the generalized Wigner-Yanase-Dyson (GWYD) skew information, we derive several uncertainty and complementarity relations with respect to mutually unbiased measurements (MUMs), and general symmetric informationally complete positive operator valued measurements (SIC-POVMs), respectively. Our results include some existing ones as particular cases. We also exemplify our results by providing a detailed example.
Computer programs in the electric power industry. Workshop
Authors: Bashkatov Aleksandr , Zasedatelev Roman , Sumerkin Evgeniy
Published: March 2021

The workshop consists of two chapters. The first one is basic, in the form of 10 works aimed at studying primary-level application programs. The second-extended-contains guidelines for seven works with software complexes (systems "Electric", DIALux) and a description of the application of programs for project purposes (calculation of the crossbar, sPlan, "1-2-3 Scheme", etc.). Along with the practical section, each topic includes reference and information support in the form of theoretical material. The papers contain basic information about the operations performed with mandatory references to specialized literature, including a review of standard examples and individual tasks in the applications section for monitoring the knowledge gained. Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation. For students in the specialty "Power supply (by industry)" when conducting laboratory work on the academic discipline "Electrical Engineering", as well as when solving design problems, during course and diploma design, organizing practices. It can be useful not only for students of electric power specialties, but also for anyone who, by the nature of their activity, is faced with the need to perform calculations of electric networks using a computer.
Preschool psychology: a practical course
Authors: Uruntaeva Galina
Published: March 2021

The textbook is devoted to the problems of studying the mental development of preschool children (the specifics of the organization, principles, methods). It consists of three sections, which present methods aimed at studying the main activities of a preschooler (play, work, drawing, designing, communication of a child with adults and peers), cognitive processes (attention, speech, perception, memory, imagination, thinking), the most important areas of personality (self-awareness, will, emotional and moral development). Meets the requirements of the federal state educational standards of higher education of the latest generation. For students of higher educational institutions studying in the direction of training "Psychological and pedagogical education" (qualification "bachelor"), it can also be useful for practical psychologists, educators of preschool educational organizations and anyone who is interested in the mental development of a preschooler, the formation of his personality.
J Marion Sims and the ‘forgotten women of gynaecology’
Authors: Wall L. Lewis
Published: March 2021

L. Lewis Wall comments on the surgical operations conducted by Dr J Marion Sims and the ethics surrounding his work
Application of Waste Egg Shell for Adsorption of Cd(II) and Pb(II) Ions to Protect Environment: Equilibrium, Kinetic and Adsorption Studies
Authors: Gurav Vijay Laxman , Samant Rajesh Ashok
Published: March 2021

In the present work, we studied the impact of adsorption parameters on adsorption of M (II) [Cadmium and Lead] using calcinated chicken egg shell as biomaterial. The characterization of biomaterial reveals; crystallite size by Scherrer formula is 66.58 nm and 9.80 m2/g BET surface area. The adsorption of cadmium and lead on calcinated egg shell was found to be dependent on equilibrium adsorption parameters. The adsorption kinetic models and adsorption isotherm were successfully applied. The removal method was validated with anodic stripping voltametric technique. For standard aqueous sample of M (II), maximum removals were obtained at pH 5 and 200 mg of adsorbent and 120 minutes of contact time. The kinetic model followed pseudo second order kinetics at equilibrium contact time of 120 minute. The amounts of M (II) adsorbed per unit mass of calcinated egg shell increases with initial concentration up to 50 mg/L followed by deviation in results were observed. The Freundlich’s adsorption isotherm model is better fitted for M (II) adsorption with R2 closed to unity i.e0.9998 for Cadmium and 0.9983 for Lead. For real samples, adsorbed M (II) also recovered with 98 + 0.5 % recovery using 10 ml of 1.0 M HCl with flow rate of 2 ml per minute.
Multi-distance surface-emitting beam profile calculation method based on the FDTD method and the diffraction theory
Authors: Ohno Hiroshi , Hashimoto Rei , Kaneko Kei , Kakuno Tsutomu , Saito Shinji
Published: March 2021

A hybrid method to calculate a multi-distance beam profile emitted perpendicular from a surface of a photonic crystal (PhC) is proposed here based on the finite-domain time-difference (FDTD) method and the diffraction theory. Although the FDTD method is available to calculate a near-field emitted from the PhC, it needs too many voxels to calculate mid- and far-fields. Thus, the diffraction theory is additionally applied to obtain the mid- and far-fields using the near-field calculated by the FDTD method. A surface-emitting quantum cascade laser (QCL) that consists of a PhC and an edge-emitting laser source is fabricated to demonstrate the validity of the hybrid method. A measured beam profile of the QCL agrees with that calculated using the hybrid method, which validates applicability of the method to a surface-emitting device.
Transient absorption with a femtosecond tunable excitation pump reveals the emission kinetics of color centers in amorphous silica
Authors: De Michele Vincenzo , Sciortino Alice , Messina Fabrizio , Cannas Marco , Boukenter Aziz , Marin Emmanuel , Girard Sylvain , Ouerdane Youcef
Published: March 2021

We report a set of femtosecond (fs) transient absorption (TA) measurements following the dynamics of the so-called nonbridging oxygen hole center in silica, a model color center in wide bandgap amorphous solids, characterized by a very large Stokes shift between the UV excitation and its associated red emission at 1.9 eV. The changes in the TA spectrum were probed in the UV-visible range at various delays after photoexcitation and analyzed as a function of the UV excitation energy, in single-photon absorption conditions. The combination of the experiments helps to clarify the defect photocycle, highlighting how TA measurements with tunable UV excitation could represent a powerful tool to investigate the dynamics of color centers embedded in transparent materials.
Brightness enhancement and beam profiles in an LD-pumped graded-index fiber Raman laser
Authors: Kuznetsov Alexey G. , Kablukov Sergey I. , Podivilov Evgeny V. , Babin Sergey A.
Published: March 2021

We demonstrate an efficient conversion of highly-multimode (M2∼34) pump beam from fiber-combined 938-nm laser diodes into a 976-nm Stokes beam of high quality (M2=1.7-2 at output powers 10-52 W) that results in record brightness enhancement (BE=73) for Raman lasers based on graded-index fiber (GIF) and other fibers. The measured shapes of the output beams in GIF show that the near-parabolic pump beam becomes depleted above the Raman threshold so that the hole in the pump beam profile is much broader than the generated Stokes beam of near-Gaussian shape. The effect is analyzed in frames of a radially-dependent balance model with an account for the mode-selective feedback by FBG, which qualitatively describes the high-quality Stokes beam generation and the hole formation, but the hole width (and its power broadening) as well as the BE values are not consistent with experiment. Possible reasons for the difference are discussed.
Optimising passive surveillance of a neglected tropical disease in the era of elimination: A modelling study
Authors: Longbottom Joshua , Wamboga Charles , Bessell Paul R. , Torr Steve J. , Stanton Michelle C.
Published: March 2021

Background

Surveillance is an essential component of global programs to eliminate infectious diseases and avert epidemics of (re-)emerging diseases. As the numbers of cases decline, costs of treatment and control diminish but those for surveillance remain high even after the ‘last’ case. Reducing surveillance may risk missing persistent or (re-)emerging foci of disease. Here, we use a simulation-based approach to determine the minimal number of passive surveillance sites required to ensure maximum coverage of a population at-risk (PAR) of an infectious disease.

Methodology and principal findings

For this study, we use Gambian human African trypanosomiasis (g-HAT) in north-western Uganda, a neglected tropical disease (NTD) which has been reduced to historically low levels (<1000 cases/year globally), as an example. To quantify travel time to diagnostic facilities, a proxy for surveillance coverage, we produced a high spatial-resolution resistance surface and performed cost-distance analyses. We simulated travel time for the PAR with different numbers (1–170) and locations (170,000 total placement combinations) of diagnostic facilities, quantifying the percentage of the PAR within 1h and 5h travel of the facilities, as per in-country targets. Our simulations indicate that a 70% reduction (51/170) in diagnostic centres still exceeded minimal targets of coverage even for remote populations, with >95% of a total PAR of ~3million individuals living ≤1h from a diagnostic centre, and we demonstrate an approach to best place these facilities, informing a minimal impact scale back.

Conclusions

Our results highlight that surveillance of g-HAT in north-western Uganda can be scaled back without substantially reducing coverage of the PAR. The methodology described can contribute to cost-effective and equable strategies for the surveillance of NTDs and other infectious diseases approaching elimination or (re-)emergence.
Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin B and miltefosine in experimental visceral leishmaniasis
Authors: Voak Andrew A. , Harris Andy , Coteron-Lopez Jose Miguel , Angulo-Barturen Iñigo , Ferrer-Bazaga Santiago , Croft Simon L. , Seifert Karin
Published: March 2021

Background

There is a continued need to develop effective and safe treatments for visceral leishmaniasis (VL). Preclinical studies on pharmacokinetics and pharmacodynamics of anti-infective agents, such as anti-bacterials and anti-fungals, have provided valuable information in the development and dosing of these agents. The aim of this study was to characterise the pharmacokinetic and pharmacodynamic properties of the anti-leishmanial drugs AmBisome and miltefosine in a preclinical disease model of VL.

Methodology / Principal findings

BALB/c mice were infected with L. donovani (MHOM/ET/67/HU3) amastigotes. Groups of mice were treated with miltefosine (orally, multi-dose regimen) or AmBisome (intravenously, single dose regimen) or left untreated as control groups. At set time points groups of mice were killed and plasma, livers and spleens harvested. For pharmacodynamics the hepatic parasite burden was determined microscopically from tissue impression smears. For pharmacokinetics drug concentrations were measured in plasma and whole tissue homogenates by LC-MS. Unbound drug concentrations were determined by rapid equilibrium dialysis. Doses exerting maximum anti-leishmanial effects were 40 mg/kg for AmBisome and 150 mg/kg (cumulatively) for miltefosine. AmBisome displayed a wider therapeutic range than miltefosine. Dose fractionation at a total dose of 2.5 mg/kg pointed towards concentration-dependent anti-leishmanial activity of AmBisome, favouring the administration of large doses infrequently. Protein binding was >99% for miltefosine and amphotericin B in plasma and tissue homogenates.

Conclusion / Significance

Using a PK/PD approach we propose optimal dosing strategies for AmBisome. Additionally, we describe pharmacokinetic and pharmacodynamic properties of miltefosine and compare our findings in a preclinical disease model to available knowledge from studies in humans. This approach also presents a strategy for improved use of animal models in the drug development process for VL.
Stochastic simulation algorithms for Interacting Particle Systems
Authors: Stutz Timothy C. , Landeros Alfonso , Xu Jason , Sinsheimer Janet S. , Sehl Mary , Lange Kenneth
Published: March 2021

Interacting Particle Systems (IPSs) are used to model spatio-temporal stochastic systems in many disparate areas of science. We design an algorithmic framework that reduces IPS simulation to simulation of well-mixed Chemical Reaction Networks (CRNs). This framework minimizes the number of associated reaction channels and decouples the computational cost of the simulations from the size of the lattice. Decoupling allows our software to make use of a wide class of techniques typically reserved for well-mixed CRNs. We implement the direct stochastic simulation algorithm in the open source programming language Julia. We also apply our algorithms to several complex spatial stochastic phenomena. including a rock-paper-scissors game, cancer growth in response to immunotherapy, and lipid oxidation dynamics. Our approach aids in standardizing mathematical models and in generating hypotheses based on concrete mechanistic behavior across a wide range of observed spatial phenomena.
Intereses organizados en las comisiones permanentes de la Cámara de Diputados de Brasil
Authors: Resende Ciro Antônio da Silva
Published: March 2021

Este artículo busca identificar qué actores estuvieron presentes en las audiencias públicas de las comisiones permanentes de la Cámara de los Diputados de Brasil en las legislaturas 53 y 54. A partir de una estrategia de análisis descriptivo, se comprueba que el sistema de comisiones estuvo marcado por un amplio conjunto de aportes generados por la participación social. Sin embargo, existe una clara asimetría de poder, caracterizada por el desempeño predominante de sectores del gobierno.
Evaluation of Angular Changes of Canine in En Masse Retraction of Maxillary Anterior Teeth Using Power Arm and Titanium Mini-Implant - A Split Mouth Randomised Control Study
Authors: Joshi Harshil Naresh , Kumar Goje Santosh , Kulkarni Narayan , Shah Romil , Chellani Samarth , Soni Jay , M. Devyani Bhardwaj
Published: March 2021

BACKGROUND This study was conducted to determine angular changes of maxillary canine in en masse retraction of anterior teeth in a new modified power arm with a conventional intraoral anchorage unit compared to a mini-implant anchorage in the first premolar extraction case. We wanted to compare angular changes of maxillary canine between modified conventional anchorage with a power arm and titanium mini-implant anchorage in en masse retraction. METHODS A total of 15 participants requiring maxillary first premolar extraction was selected for this study. In each participant, the en mass retraction was carried out with miniimplants on one side & modified conventional anchorage with a power arm on the other side. The choice of mode of retraction on the right and the left side was done based on the coin flip method. Angular position of the maxillary canine was evaluated on orthopantomogram (OPG) & diagnostic cast. RESULTS A mean disto-palatal rotation observed post retraction was of 9° on the conventional anchorage side & 9.86° on the mini-implant anchorage side. A mean difference in maxillary canine angulations post retraction was 1.13° on the conventional anchorage side and 0.93° on the mini-implant side. An increase in angle suggested the tipping of canine teeth. The difference was very small which was not statistically & clinically significant. CONCLUSIONS There was no difference in the type of tooth movement during retraction by miniimplant and power arm suggesting minimal variation in teeth movement in the anterior region. So, the choice mainly depends on the type of the anchorage required in the given clinical situation. KEY WORDS Anchorage, Mini-Implant, Power Arm, Type of Tooth Movement
Mental Status of Dental Students during Lockdown Due to Covid-19 Pandemic - A Cross Sectional Study in Western Maharashtra
Authors: Valekar Seema Suresh , Phaphe Sandesh Ashok , Sarode Karishma Rajiv
Published: March 2021

BACKGROUND Since the World Health Organization declared coronavirus disease 2019 (Covid-19) a pandemic, it has become a major challenge to public health all around the world. The situation is physically as well as mentally challenging for dental practitioners, teaching faculty, and dental students. We wanted to determine the stress among dental students due to the lockdown. This will aid us in determining the amendments to be made to help students manage the stress in such a critical situation the world is facing. METHODS This is a cross-sectional quantitative study done using a voluntarily filled online questionnaire. The survey was conducted on undergraduate dental students of School of Dental Sciences, Karad. Third and final year students were included in the study as they are more into clinical practice. Out of 163 students, 118 students responded to the questionnaire. RESULTS 93 % of the total respondents reported that the period of lockdown will have an impact on the mental wellbeing of the students. Stress due to loss of academic year, patients missing appointments, dentist’s being at high risk was found to be 97 %, 75 %, 89.8 % respectively. CONCLUSIONS A significant number of dental students had disturbed mental wellbeing during the period of lockdown. Supporting the mental health of all health care workers must be a critical part of the public health response, and special efforts should be directed to vulnerable sectors. KEY WORDS Mental Status, Students, Covid-19, Epidemic
Pengaruh Kontestasi Politik Desa terhadap Konflik Ahmadiyah di Gegerung-Lombok Barat
Authors: Baihaqi Mohamad
Published: March 2021

Penyerangan terhadap Jemaat Ahmadiyah di Gegerung-Lombok terjadi pada 2005-2006 dan 2010. Pada tahun itu kontestasi pemilihan kepala desa bakal dilaksanakan. Beberapa bulan menjelang pemilihan kepala desa, salah satu tokoh agama kerap menyampaikan ceramah yang bernada provokatif. Belakangan diketahui bahwa tokoh agama tersebut berafiliasi dengan salah satu kontestan calon kepala desa. Penelitian ini mengungkapkan bahwa konflik dan kekerasan terhadap Jemaat Ahmadiyah di Gegerung terjadi secara instrumental yang disebabkan oleh adanya kepentingan politik tokoh agama dan salah satu kandidat dalam pemilihan kepala desa setempat. Sekaligus menunjukkan bahwa konflik dan kekerasan terhadap Jemaat Ahmadiyah tidak hanya disebabkan oleh faktor perbedaan keyakinan antara Jemaat Ahmadiyah dan warga Desa Gegerung-Lombok Barat. Bukan pula terjadi semata karena adanya fatwa MUI dan peraturan diskriminatif bupati Lombok Barat. Keduanya tidak berhubungan secara langsung sebagai pemicu konflik dan kekerasan. Konflik dan kekerasan terhadap Ahmadiyah di Desa Gegerung justru terjadi karena adanya campur tangan politisi dan tokoh agama di yang menjadikan perbedaan sebagai komoditas politik.[The attack on the Jemaah Ahmadiyah in Gegerung-Lombok occurred in 2005-2006 and 2010 in conjunction with the contestation for the headman election. A few months before the village headman election, one of the religious leaders often delivered provocative lectures. It was later discovered that this religious figure was affiliated with one of the village head candidate contestants. This research focuses on whether there is a relationship between the political situation in Gegerung Village and the presence of the Jemaah Ahmadiyah? Does this relationship have a correlation with conflict and violence? Using the descriptive analysis method, this research aims to reveal the relationship between the potential situation of Gegerung Village and the existence of the Jemaah Ahmadiyah and its correlation with conflict and violence. The results showed that the conflict and violence against the Jemaah Ahmadiyah in Gegerung occurred instrumentally due to the political interests of religious leaders and one of the candidates in the local village head election. In addition, the researcher also found that the conflict and violence against the Jemaah Ahmadiyah was not only caused by factors of differences in beliefs between the Ahmadiyah congregation and residents of Gegerung Village-West Lombok, nor was it simply due to the MUI fatwa and the discriminatory regulations of the West Lombok Regent. Both are not directly related as triggers of conflict and violence. The conflict and violence against Ahmadiyah in Gegerung Village actually occurred because of the interference of politicians and religious figures who made differences as a political commodity.]
Potential mechanisms of action of convalescent plasma in COVID-19
Authors: Franchini Massimo , Glingani Claudia , Liumbruno Giancarlo Maria
Published: March 2021

The COVID-19 pandemic will be remembered as one of the worst catastrophic events in human history. Unfortunately, no universally recognized effective therapeutic agents are currently available for the treatment of severe SARS-CoV-2 infection. In this context, the use of convalescent plasma from recovered COVID-19 patients has gained increasing interest thanks to the initially positive clinical reports. A number of mechanisms of action have been proposed for convalescent plasma, including direct neutralization and suppression of viremia, anti-inflammatory and immunomodulation effects and mitigation of the COVID-19-associated hypercoagulable state. These immune and non-immune mechanisms will be critically discussed in this narrative review.
Univerbation
Authors: Lehmann Christian
Published: March 2021

Univerbation is the syntagmatic condensation of a sequence of words recurrent in discourse into one word, as when the Spanish combinationa tras(to back) becomesatrás‘behind’. It affects both lexemes and grammatical formatives. Unlike processes of word formation, including conversion of a syntactic construction into a word, as inforget-me-not, and compounding, as in Spanishlavaplatos‘dishwasher’, univerbation is a spontaneous process. There are two main types of univerbation: phrasal univerbation downgrades a phrase to a word, as when Latinterrae motus‘earth’s movement’ becomes Spanishterremoto‘earthquake’. Transgressive univerbation coalesces a string of words which do not form a syntagma into a word, as when Frenchpar ce quebecomesparce que. A set of univerbations may share structural features and may therefore evolve into a pattern of compounding. Thus,blackbirdoriginated by univerbation, but may now provide a pattern of compounding. As a consequence, univerbation and compounding are not always easily distinguishable. The discussion uses empirical evidence adduced in earlier work, mostly from Romance and Germanic languages. Its aim is not to present novel phenomena but to provide a theoretical background for the phenomenology and improve on available analyses.
Ageing mechanisms of the papers with zeolite and PCC fillers
Authors: Engin Merve , Yılgör Nural , Atik Celil
Published: March 2021

This work has been conducted to investigate the effect of accelerated ageing on the filler-free (control) handsheets and the ones having Precipitated Calcium Carbonate (PCC) and Zeolite (Clinoptilolite) fillers. The diagnosis approach of this work has been based on the use of the techniques of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray diffraction (XRD). The FT-IR technique has allowed identifying the changes in cellulose components of handsheets. Likewise, the XRD technique has provided to diagnose the changes in crystallinity of the handsheets and fillers. The results found out that PCC and Zeolite fillers could be easily added to the structure of the paper network by changing various experimental variables. The loss of C−O functional groups and the formation of carbonyl groups in handsheets has been analysed by accelerated ageing. The spectroscopy results confirmed that usage of zeolite filler has a retarding and structurally improving effect on the glycosidic linkages. Recent findings have been provided new insights into the role of the synergistic effect of the combination of PCC and zeolite fillers in the decelerating of certain ageing mechanism.
Distributive Consequences of Risk Privatization: The Case of the Swedish Unemployment Insurance System
Authors: Lindellee Jayeon
Published: March 2021

The public unemployment insurance program in Sweden has retrenched in terms of its benefit generosity in the last three decades. As a response to this trend, in which an ever-smaller proportion of the previous income of unemployed persons is compensated by public unemployment insurance benefit, complementary income insurance schemes provided by unions have expanded rapidly in the last 15 years, currently covering one half of the working population. What does this change mean for people who need income protection upon unemployment and are more likely to find themselves unemployed or underemployed? By analyzing survey-based benefit recipiency data among retail workers who were unemployed in 2014, this article explores the outcomes of the multi-pillarized unemployment benefit provision system in Sweden. While public unemployment insurance benefit does not fully compensate for the income loss for the majority of retail workers, the promise of a complementary income insurance scheme seems to be illusory for many individuals as they repeatedly oscillate between precarious work and benefits, accompanied by the burden of navigating a complex system.
Medicine 2.0 Meets Ontario Hospitals: Why Hospitals Have Been Slow to Adopt Social Media
Authors: Males Anne Marie
Published: March 2021

Eighty percent of Canadians are using the Internet and many are using social media. In the U.S. one in five consumers are using social media to access information about hospitals and it is influencing their decisions about where to seek care. Despite this growth, hospitals in Canada and the U.S. appear reluctant to join the conversation with just 27 and 21 per cent of hospitals respectively maintaining a social media presence despite mounting evidence that social media can increase health literacy, aid in fundraising, allow for patient self-care and facilitate research and educational opportunities. The barriers that are preventing hospitals from fully embracing social media include fear of the unknown, lack of established best practices, difficulties in determining return on investment and hospital culture and values barriers that are in conflict with social media culture and values.
Biomechanical Effects of a 6-Week Change of Direction Speed and Technique Modification Intervention: Implications for Change of Direction Side step Performance
Authors: Dos'Santos Thomas , Thomas Christopher , Comfort Paul , Jones Paul A.
Published: March 2021

Dos'Santos, T, Thomas, C, Comfort, P, and Jones, PA. Biomechanical effects of a 6-week change of direction speed and technique modification intervention: implications for change of direction side step performance. J Strength Cond Res 36(10): 2780–2791, 2022—The aim of this study was to evaluate the biomechanical effects of change of direction (COD) speed and technique modification training on COD performance (completion time, ground contact time [GCT], and exit velocity) during 45° (CUT45) and 90° (CUT90) side step cutting. A nonrandomized, controlled 6-week intervention study was administrated. Fifteen male, multidirectional, sport athletes (age, 23.5 ± 5.2 years; height, 1.80 ± 0.05 m; mass, 81.6 ± 11.4 kg) formed the intervention group (IG) who participated in two 30-minute COD speed and technique modification sessions per week, whereas 12 male, multidirectional, sport athletes (age, 22.2 ± 5.0 years; height, 1.76 ± 0.08 m; mass, 72.7 ± 12.4 kg) formed the control group (CG) and continued their normal training. All subjects performed 6 trials of the CUT45 and CUT90 task whereby pre-to-post intervention changes in lower-limb and trunk kinetics and kinematics were evaluated using 3-dimensional motion and ground reaction force analyses. Two-way mixed analysis of variances revealed significant main effects for time (pre-to-post changes) for CUT45 completion time, exit velocity, and CUT90 completion time (p ≤ 0.045; η2 = 0.152–0.539), and significant interaction effects of time and group were observed for CUT45 completion time, GCT, exit velocity, and CUT90 completion time (p ≤ 0.010; η2 = 0.239–0.483), with the IG displaying superior performance postintervention compared with the CG (p ≤ 0.109; g = 0.83–1.35). Improvements in cutting performance were moderately to very largely associated (p ≤ 0.078; r or ρ = 0.469–0.846) with increased velocity profiles, increased propulsive forces over shorter GCTs, and decreased knee flexion. Change of direction speed and technique modification is a simple, effective training method requiring minimal equipment that can enhance COD performance, which practitioners should consider incorporating into their pitch- or court-based training programs.
Aspectos políticos da Idade média: articulações de poder segundo a obra de Georges Duby
Authors: Viebrantz Vítor Mateus
Published: March 2021

No período situado entre os séculos X-XV, as relações de poder na Europa ocidental se encontravam inseridas em um complexo de articulações e desdobramentos. Em A Idade Média na França: de Hugo Capeto a Joana d’Arc (987-1460), Georges Duby (1992) investiga a trajetória e as especificidades das expressões do poder a partir do exemplo da França feudal, percebendo suas repercussões nos diversos domínios humanos e políticos. Partindo da obra citada, o artigo analisa o arcabouço da organização política medieval a partir de quatro características indicadas por Duby: as dimensões doméstica e sagrada do poder e seu carácter masculino e fragmentado. Associam-se a obra outras bibliografias para viabilizar um horizonte de compreensão das possibilidades e circunstâncias do poder na época medieval. A abordagem metodológica utilizada é revisão bibliográfica. Palavras-chave: Política; Poder; Feudalismo.AbstractIn the period situated as the 10th - 13th centuries, the power relations in western Europe were inserted in a complex of articulations and unfoldings. In A Idade Média na França: de Hugo Capeto a Joana d’Arc (987-1460), Georges Duby (1992) investigates the trajectory and specificities of expressions of power as of on the example of feudal France, realizing its repercussions in the various human and political domains. Correlating with the oeuvre cited, the article analyzes the framework of medieval political organization as of four characteristics indicated by Duby: the domestic and sacred dimensions of power and its masculine and fragmented character. Other bibliographies are associated with the oeuvre to make viable a horizon of understanding the possibilities and circumstances of power in medieval period. The methodological approach used is bibliographic review.Keywords: Politics; Power; Feudalism.
Revista Charrua – relativizações das retóricas de intelectual revolucionário e literatura de combate (1977-1986)
Authors: Batista Bortolotti João Antônio
Published: March 2021

Este artigo objetiva contextualizar e analisar os significados da Revista Charrua (1984-1986), periódico idealizado e publicado por um grupo de jovens escritores imbuídos de ideias e intenções de demarcar um novo momento da literatura moçambicana, distanciando-se das retóricas de intelectual revolucionário e poesia de combate, caras ao projeto nacional do Estado-Frelimo. Para tal, contextualizo brevemente o momento da formação da Frente de Libertação de Moçambique, e mais amplamente o período após a independência, marcado pelo início de uma guerra civil, bem como por um projeto nacionalista autoritário, a envolver a elaboração de um conceito de cultura moçambicana.Palavras-chave: Revista Charrua, Moçambique, literatura moçambicana, Frelimo, Renamo, poesia de combate.Abstract:This paper aims to contextualize and analyze the meanings of Charrua Magazine (1984-1986), idealized and published by a group of young writers imbued with ideas and intentions of lining off a new moment in Mozambican literature, distancing from the rhetoric of revolutionary intellectual and combat poetry, dear to the State’s national project. In order to accomplish that, I briefly contextualize the moment of Mozambique Liberation Front’s formation, e more widely the moment after independence, marked by the beginning of a civil war, as well as by an authoritarian nationalist project, which involved the elaboration of a concept of Mozambican culture.Keywords: Charrua Magazine, Mozambique, Mozambican literature, Frelimo, Renamo, combat poetry.
“Colorindo o passado com um valor que nos é caro”: memórias que educam, histórias que se entrelaçam
Authors: Vieira Maria Letícia
Published: March 2021

Este estudo versa sobre a cultura escolar no Colégio Alfredo Dantas, tomando como objetivo trabalhar com a Cultura Escolar desenvolvida na instituição já mencionada no período de 1968- 1987, o qual se situa no campo da História Cultural em diálogo com a História da Educação a partir das práticas de memória, dialogando com as perspectivas de Dominique Julia (2001), Verena Alberti (2004) e Foucault (2014). Adotamos como metodologia a coleta de narrativas de memória de ex-alunos e ex-professor, em que estes sujeitos educativos representam a escola em suas lembranças a partir das festividades, dos desfiles cívicos, do fardamento e apontam para sensibilidades educativas, cujos atos de memória permite alcançar. Esta pesquisa, acaba nos fazendo perceber que o Colégio Alfredo Dantas, é também espaço de sensibilidade, em que as emoções se afloram e as subjetividades podem ser lidas por meio das memórias.Palavras-chaves: Cultura Escolar; Memória; Práticas Educativas; Ditadura Militar. AbstractThis study deals with school culture at Alfredo Dantas School, taking as objective to work with the School Culture developed in the institution already mentioned in the period 1968-1987. These characteristics locate this study in the field of Cultural History, in dialogue with the History of Education from the practices of memory, dialoguing with the perspectives of Domenique Julia (2001), Verena Alberti (2004) and Foucault (2014). We adopted as method the collection of memory narratives of former students and teachers, since these educational subjects represent the school in their memories as of the festivities, civic parades and uniforms. Data collected point to educational sensitivities, whose acts of memory allow to achieve. This research ends up making us realize that the Alfredo Dantas School is also a space of sensitivity, in which emotions surface and subjectivities can be read through memories.Keywords: School Culture; Memory; Educational Practices; Military Dictatorship.
Representações das histórias das mulheres na coleção indumentária do Museu Julio de Castilhos (1995-2010)
Authors: Da Silveira Andréa Reis
Published: March 2021

O artigo apresenta a investigação sobre as representações das histórias das mulheres no acervo de indumentária do Museu Julio de Castilhos (MJC), PoA, RS, no recorte temporal de 1995-2010. Analisa os objetos de três exposições que abordaram perfil das mulheres rio-grandenses. Avalia as doações e a musealização feitas por mulheres, nas quais denominei intelectuais mediadoras. Os dados assinalaram que as construções narrativas da historicidade das peças passaram pela interpretação desse grupo de classe média, branco e de idade cronológica média, que compôs as informações que constam na documentação museológica do banco de dados Donato, e, no Livro Diário do acervo. Os resultados apontaram permanências de estereótipos sobre as histórias das mulheres, problematizando as ações educativas realizadas pelo MJC.Palavras-chave: Museu; Coleção indumentária; História das mulheres.AbstractThe paper presents the investigation about the representations of the women's stories in the collection of clothing of the Julio de Castilhos Museum (MJC), PoA, RS, in the 1995-2010 period.  The objects of three exhibitions that addressed the profile of women from Rio Grande do Sul are analyzed. It evaluates donations and musealization made by women, which I have called mediating intellectuals. Data indicated that the narrative constructions of the historicity of the pieces went through the interpretation of this group of middle class, white and middle chronological age, which composed the information contained in the museum documentation of the Donato database, and in the Daily Book of the collection. The results pointed to the permanence of stereotypes about the women's stories, problematizing the educational actions carried out by the MJC.Keywords: Museum; Collections; women's history.
Organoids as tools to investigate the molecular mechanisms of male infertility and its treatments
Authors: Kanbar Marc , Vermeulen Maxime , Wyns Christine
Published: March 2021

Organoids are 3D structures characterized by cellular spatial organizations and functions close to the native tissue they mimic. Attempts to create organoids originating from several tissues have now been reported, including the testis. Testicular organoids have the potential to improve our knowledge of the mechanisms that regulate testicular morphogenesis, physiology, and pathophysiology. They could especially prove as useful tools to understand the complex mechanisms involved in the regulation of the germ cell niche in infertility cases as they offer the possibility to control and modify the nature of cell types before self-assembly and thereby opening the perspective for developing innovative methods to restore fertility. To date, there are only few studies targeted at testicular organoids’ formation and even less describing the generation of organoids with both testis-specific structure and function. While researchers described interesting applications with regards to testicular tissue morphogenesis and drug toxicity, further research is needed before testicular organoids would eventually lead to the generation of fertilizing spermatozoa. This review will present the conventional systems used to induce in vitro maturation of testicular cells, describe the different approaches that have been used for the development of testicular organoids and discuss the potential applications they could have in the field of male reproductive biology.
The Influence of Social Class on Family Participation in Children’s Education: A Case Study
Authors: Vazquez Salvador R. , Greenfield Patricia M.
Published: March 2021

Parental involvement in children’s education is commonly accepted as beneficial. However, family social class plays a crucial role in the efficacy of homework help. In a comparative case study, a low-income immigrant family from Mexico and a middle-income family in Los Angeles were observed helping their children with math homework and were asked questions about goals, tutoring strategies, and beliefs about learning. Qualitative analysis focused on two effective teaching methods: scaffolding and productive struggle. The low-income mother with little formal education provided direct help rather than a scaffold, and disapproved of hard problems. However, an older sibling with more education than her mother used scaffolding and believed that difficult problems aid learning. In these respects, she resembled the college-educated middle-income mother. The sister exemplifies how older siblings in immigrant families provide bridges to educational achievement for younger siblings. We suggest effective ways for schools to involve parents who lacked educational opportunity themselves to participate in the education of their children.
 
How to cite this article: Vazquez, S. R., & Greenfield, P. M. (2021). The Influence of Social Class on Family Participation in Children’s Education: A Case Study. Revista Colombiana de Psicología, 30(1), 133-147. https://doi.org/10.15446/rcp.v30n1.89185
Life of Ramanandi Centres in Varanasi
Authors: Bevilacqua Daniela
Published: March 2021

The Ramanandi samprad?y is a Vaisnava religious order supposedly formed by Ramanand in Varanasi in the fifteenth century. The sampraday, nevertheless, primarily developed and spread in the north-west of India, and Ramanandi centres (re)appeared in Varanasi around the nineteenth century. Although renowned for its Saiva temples and ascetics, Varanasi, indeed, also manifests a Vaisnava nature. Referring to an inquiry on the ascetic groups present in the city led by anthropologists Sinha and Saraswati in the 1960s, this article focuses its attention on Ramanandis centres in the twenty-first century. Following the list of places provided by the two scholars, using local traditions and ethnographic data, the article provides glimpses into the life of ‘subaltern’ Ramanandi temples and asrams, showing how today the survival of local religious centres depends on the support of lay people, who may be attracted by devotion to specific places, but mostly by the charisma and the activities of their leaders and the religious community they are able to create.
Real life study of the use of omalizumab for pediatric patients with multiple food allergies
Authors: Crespo Judit Barrena , Domingo Marta Viñas , Hernández Arauzo Nora , Castillo M. José , Delavalle M. Belén , Saura Foix M. Pilar , Sánchez Davinia Vázquez , Izquierdo-Dominguez Adriana
Published: March 2021

Background: Multiple food allergies (MFAs) affect 30% of the child population with food allergy. The current treatment is the exclusion diet, which frequently affects the quality of life for these patients. The objective of the study was to describe the effect of omalizumab treatment in children diagnosed with MFAs who experienced frequent anaphylactic reactions and the impact on their quality of life.Material and methods: A descriptive observational study. Patients with severe food restrictions and high-risk due to multiple episodes of anaphylaxis were included. The allergy was confirmed by compatible clinical, skin tests, positive specific IgE and oral food challenges (OFCs). Omalizumab treatment was initiated and the impact on the life quality of patients and their families was assessed using the validated Food Allergy Quality of Life Questionnaire-Parent Form.Results: Five patients with an average age at diagnosis of 3.58 years (range between 1.5–7.9 years), were diagnosed with MFAs. All patients presented with anaphylaxis. All patients were treated with omalizumab between 2013 and 2019. Omalizumab treatment was initiated at a mean age of 6.05 years (range between 4.5–8.25 years). All patients have undergone OFC to reintroduce food successfully. 2 patients had their dose of omalizumab reduced by half, and 1 patient has had the time interval extended between administrations due to the maintenance of food tolerance. No immediate local or systemic adverse reactions were documented. Two patients have commenced omalizumab administration at home without incident.Conclusions: Children with MFAs who are treated with omalizumab do not show reactions in response to most of the foods to which they previously had anaphylaxis. Consequently, these patients were able to significantly expand the variety of their diet, improving the life quality and avoid anaphylaxis following the inadvertent intake of these foods.
Osteoporosis or Low Bone Mass in Older Adults: United States, 2017-2018
Authors: Sarafrazi Neda
Published: March 2021

This report provides prevalence estimates of osteoporosis and low bone mass among adults aged 50 and over in the United States in 2017-2018.
η-Ricci Solitons and Gradient Ricci Solitons on f-Kenmotsu Manifolds
Authors: Siddiqi Mohd
Published: March 2021

The aim of the present research article is to study the f-kenmotsu manifolds admitting the η-Ricci Solitons and gradient Ricci solitons with respect to the semi-symmetric non metric connection.
Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
Authors: Dawood Ali A. , Altobje Mahmood A. A. , Alrassam Zeyad T.
Published: March 2021

Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV.