Correction of immune disorders under the influence of pharmacotherapy and extracorporal magnetic stimulation in patients after surgical treatment of prostate adenoma
Authors:   Kabardino-Balkarian State University named after H. M. Berbekov, Nalchik, Russia, Nazranov Beslan M. , Tsogoev Alan S. ,   North Ossetian State Medical Academy, Vladikavkaz, Russia, Chalaya Elena N. ,   North Caucasian Federal Scientific and Clinical Centre of the Federal Medical and Biological Agency, Yessentuki, Russia, Efimenko Natalya V. ,   North Caucasian Federal Scientific and Clinical Centre of the Federal Medical and Biological Agency, Yessentuki, Russia
Published: June 2024

Abstract. The literature analysis shows that benign prostatic hyperplasia is associated with chronic prostatitis in 50–70 % of cases. Moreover, the course of benign prostatic hyperplasia is associated with immunological disorders at the systemic and local levels. The presence of a chronic, sluggish process is accompanied by endogenous intoxication, which leads to a gradual decrease in the body’s immune reactivity. Purpose of the study. To study the role of the complex effects of pharmacotherapy and extracorporeal magnetic stimulation (EMS) in the correction of immune disorders in patients after surgical treatment of prostate adenoma. Material and methods. Observations were carried out on 88 patients after surgical treatment of pancreatic adenoma, who underwent medical rehabilitation at stages II and III. At stage II, in the comparison group (CG), 43 patients received standardized drug therapy and individual physical therapy; in the main group (MG), 45 patients additionally received immunomodulatory therapy with Tamerit. At stage III in the GS, patients continued pharmacotherapy, exercise therapy and transrectal magnetic therapy; in the OG, 45 patients were additionally prescribed EMS. To study the content of interleukins (IL), the enzyme-linked immunosorbent assay method was used; To assess the quality of life, the IPSS-QOL (International Prostate Symptom Score — Quality-of-Life) questionnaire and SF-36 (The Short Form-36) were used.Significance level — p < 0.05. Results. After the II inpatient stage of rehabilitation in patients with OH after surgical treatment of pancreatic adenoma, the level of proinflammatory ILs decreased on average by 47.5 % (p < 0.01) with an increase in the level of anti-inflammatory IL-10 by 36.2 % (p < 0.01). After the third outpatient stage of rehabilitation, the positive dynamics increased significantly and amounted to 63.2 % (p < 0.01) and 51.9 % (p < 0.01), reaching normative values in the population. It should be noted that the achieved results are maintained in the long term. In the GS, in all cases after stages II and III of rehabilitation, the positive dynamics were significantly lower (p < 0.05 — p < 0.01). With the same reliability, in the group there was a decrease in the severity of urinary disorders (p < 0.01), restoration of quality of life (p < 0.05) according to the IPSS-QOL and SF-36 questionnaires with significant intergroup values (p < 0.05). Conclusion. The integrated use of pharmacotherapy and EMS in patients after surgical treatment of pancreatic adenoma provides significant correction of immune disorders and restoration of physical and mental health.