bluuebunny/crossref_metadata_2025 huggingface dataset:
A real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events for Tivozanib
Authors: Ma Xiaohan , Chen Sheng , Xuan Lan , Lian Zuping , Hou Encun
Published: April 2024

This study analyzes adverse drug events (ADEs) associated with Tivozanib, sourced from the Food and Drug Administration Adverse Event Reporting System (FAERS) database. We collected ADE data for Tivozanib from 2021 Q2 through 2023 Q4. Post-standardization, we employed several signal quantification methods for analysis, such as the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propensity for Neural Networks (BCPNN), and the Multi-item Gamma Poisson Shrinker (MGPS). In this analysis of 1,142 ADE reports citing Tivozanib as the primary suspect, we identified 69 adverse reaction terms (PTs) across 21 system organ classifications (SOCs). The three most prevalent SOCs were general disorders and administration site conditions (841 incidents, ROR 1.27, PRR 1.21, IC 0.28, EBGM 1.14), gastrointestinal disorders (669 incidents, ROR 2.52, PRR 2.25, IC 1.17, EBGM 2.25), and investigations (322 incidents, ROR 1.45, PRR 1.42, IC 0.5, EBGM 1.42). Notably, fatigue and hypertension were the most frequently reported adverse events associated with Tivozanib, with hypothyroidism also demonstrating significant signal intensity. While Tivozanib offers therapeutic benefits, it also carries the risk of several adverse reactions. Clinicians should vigilantly monitor patients for signs of fatigue, hypertension, hypothyroidism, and other events during its clinical use.
Association of preoperative cognitive frailty with postoperative complications in elderly patients under general anesthesia: a prospective cohort study
Authors: FANG Jiamin , LIANG Hao , CHEN Muxin , ZHAO Yidi , WEI Lin
Published: April 2024

Background
Cognitive frailty is defined as the coexistence of physical frailty and mild cognitive impairment, which is associated with adverse outcomes. Due to various factors such as age-related changes in the brain and the presence of comorbidities, the elderly are more susceptible to cognitive frailty.
Objective
To investigate the effect of preoperative cognitive frailty on postoperative complications in elderly patients.
Methods
This prospective observational study was conducted among 253 patients aged 60–85 years, who underwent elective orthopedic and abdominal surgery (postoperative hospital stay ≥ 3 days ) in the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from May 2023 to November 2023. Cognitive frailty was assessed using the MoCA for the cognitive status and the Fried criteria for five frailty scales. The participants were split into the following groups: group A, neither frail nor cognitive impairment; group B, only frailty ; group C, only cognitive impairment; group D, cognitive frailty. Primary outcome was the impact on postoperative complications. Secondary outcomes included mobility disability, prolonged hospital stay, re-operation and 90-day readmission.
Results
The median age ( interquartile range ) of participants was 69 (65–73) years, of which 40.3% were male. The prevalence of cognitive frailty was 17.8%. The incidence of postoperative complications was 18.2% in group A, 50.0% in group B, 37.4% in group C, and 75.6% in group D. The difference was significant (P < 0.001). In the multivariate analysis, cognitive frailty [odds ratio (OR), 16.84; 95% confidence interval (CI), 4.54–62.37], only frailty (OR, 7.86; 95%CI, 2.12-29. 12), only cognitive impairment (OR, 4.22; 95%CI, 1.62–11.02).
Conclusions
Cognitive frailty was associated with higher risks of postoperative complications in elderly patients undergoing general anesthesia. It indicates that clinicians should pay much attention to these elderly with cognitive frailty.
Liver disease as new work in the context of protocolised primary care - Do GPs have a role? A qualitative interview study
Authors: Jarvis Helen , Sanders Tom , Hanratty Barbara
Published: April 2024

Objectives
Liver disease is common, but not part of routine chronic disease management in primary care. The aim of this study was to explore the challenges of implementing pathways of care for liver disease within existing highly protocolised structures in primary care.
Methods
Semi-structured interviews with 20 health professionals working in primary care. Interviews were informed by normalisation process theory (NPT) and boundary theory. Data were subject to thematic analysis.
Results
Three themes were identified relating to chronic disease work; definitions; need and worth, and roles. Participants identified that understanding and value of roles within chronic disease management were pre-defined by targets imposed on them as part of national incentives schemes. Structural boundaries constrained professional autonomy and the potential to influence this area of primary care management, including taking on new work.
Discussion
The inability to influence care decisions blurs occupational boundaries and goes to the core of what it means to be a professional. Unless liver disease sits within this target-based system, it is unlikely to become part of routine work in primary care.
Caval Index is a Predictor of Mortality in Patients with Acute Ischemic Stroke: A Prospective Observational Study
Authors: Ercan Volkan , Ozakin Engin , Ozdemir Atilla Ozcan , Aykac Ozlem , Karakilic Evvah , Acar Nurdan , Kaya Filiz Baloglu , Canakci Mustafa Emin , Cure Ruhi
Published: April 2024

Objective
Dehydration is related with a higher risk of complications, such as venous thrombosis. Stroke occurs more frequently in the elderly, and dehydration is common in these patients. The aim of this study is to determine the dehydration in patients with acute ischemic stroke and its effect on prognosis.
Methods
In this observational cohort study, we included prospectively and consecutively patients who underwent intravenous fibrinolytic therapy and/or mechanic revascularization. Inferior vena cava inferior (IVC) diameter, blood urea nitrogen/creatinine ratio and glomerular filtration rate were measured at the time of first admission to the emergency department to determine volume status. Dehydration was defined as collapse of >50% in IVC diameter. Demographic and clinical data were recorded. At admission NIHSS was used for neurological severity. At discharge and three months after the stroke modified Rankin Scale (mRS) was used for functional outcome. Poor outcome was defined as mRS: 3-6.
Results
We evaluated 211 patients, 77% presented with anterior circulation occlusion. Dehydration was detected in 57 (34.7%) in anterior occlusion and 15 (46.8%) in posterior occlusion patients at emergency department admission. Poor outcomes were found to be more common in patients with hypovolemia and in those with anterior circulation disorder who received conservative treatment and intravenous thrombolytic therapy than in normovolemic patients (p = 0.032 and p = 0.005, respectively).
Conclusion
Dehydration is common in acute ischemic patients in emergency admission. Although laboratory parameters are used to detect dehydration, collapse determined by measuring IVC diameter is a fast and useful method for emergency physicians to determine volume status in acute stroke patients. Further research should aim to determine dehydration in stroke patients for fluid resuscitation in the emergency department.
A Modification to the Alkire-Foster Method When Data Are Cardinal
Authors: Sun Kan
Published: April 2024

This paper introduces a modification to the standard Alkire-Foster (AF) Method (Alkire and Foster, 2011a,b) for multidimensional poverty measurement. This modification incorporates cardinal information during the identification step when feasible. Following the typical identification-aggregation structure, the adjusted method considers both the number of deprivations and aggregate (or average) achievement for identification and employs the adjusted FGT class of measures for aggregation. The proposed method upholds key axioms, including subgroup decomposability, replication invariance, symmetry, and poverty focus. Empirical results, utilizing data from Indonesia and South Africa, reveal that the modified method is less sensitive to changes in the poverty cutoff and exhibits an enhanced focus on individuals experiencing deeper deprivations.
Community-Based Enterprise Development in the AMIA (Adaptation and Mitigation Initiative in Agriculture) Villages in San Francisco, Quezon, Philippines
Authors: Miano Leomar , Cabrera Gino , Yao Claire Ann , Laguador Aurita , Cayabat Chona
Published: April 2024

This research project sought to establish a community-based enterprise in the AMIA Villages in San Francisco, Quezon, Philippines. This was carried out through a three-phase community-based participatory action research (CBPAR). The first phase constitutes the needs assessment which was done using mixed-methods – sequential explanatory research to generate an action plan for the succeeding phases. The second phase is the product formulation and production processes which were composed of participatory learning trials (PLT), physicochemical and microbial analysis, and packaging. The last phase is the capacity-building and market linkage survey. Results showed that the villagers are producing bananas, coconut, swine, poultry, yam or ube, and rice. However, yam or ube was the top raw agricultural produce with the potential for product development. Six (6) ube food products were developed – ube nuts polvoron, ube pastillas, ube powder, ube mochi, ube halaya, and ube pocket pie. Among these products, only ube powder was subjected to testing while ube nuts polvoron, ube pastillas, and ube powder were labeled and packaged. These were some initial steps to establish the legal requirements for the approval of the Food and Drugs Administration (FDA). The product costing for ube powder commands higher profit but on the contrary, it is seen with the least market value due to its unknown purpose. Ube food production together with identified topics for entrepreneurial development formed a series of modules for capability building. Lastly, there were eleven (11) cooperatives identified as the potential market linkage of the AMIA Villages. Specific recommendations to improve the products and strengthen the enterprise were set forth.
Biological characterization and clinical value of PLOD gene family in clear cell renal cell carcinoma
Authors: Shang Xuan , Liu Liu , Yan Min , Ren Rui-Min , Guo Ke-Xin , Wang Jie , Zhang Wei , Chang Jia-Song , Li Jia-Lei , Gao Li-Juan , Cao Ji-Min
Published: April 2024

Background
Studies have identified that procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) gene family is closely related to tumor progression and metastasis in various cancers. However, the expression pattern, clinical value and function of PLOD gene family in clear cell renal cell carcinoma (ccRCC) have not yet been studied.
Methods
We investigated the expression, prognostic value, immune cell infiltration, genetic mutation, cell migration, and biological function of the PLOD gene family in ccRCC through comprehensive bioinformatic analysis and experimental validation, and predicted potential chemicals which regulate the expression of PLOD gene family using comparative toxicogenomics database (CTD) and docking analysis.
Results
The mRNA and protein expressions of PLOD gene family were highly increased in ccRCC tissues compared with normal tissues, and high expressions of all the three PLOD genes were positively related to every clinicopathological stages, poor overall survival (OS) and disease-free survival (DFS) in ccRCC patients. Fifty co-expressed genes of PLODs were found related with ccRCC. Functional enrichment analysis revealed that collagen synthesis, ECM-receptor interaction and lysine degradation were key biological functions of PLODs in ccRCC. A variety of chemicals were predicted to regulate the expression of PLOD gene family especially acetaminophen.
Conclusion
High expression of PLOD gene family is closely related to poor prognosis of ccRCC and they can predict any stage of ccRCC. PLOD gene family may serve as a prognostic biomarker and even a therapeutic target for ccRCC.
Predictors of quality of life among caregivers of patients with moderate to severe kidney disease: an Australian cross-sectional study
Authors: Zimbudzi Edward , Blessan Asha , Fraginal Denise , GUTE Lelise , WANG Qiumian , ZIGANAY Shari
Published: April 2024

Background
Little is known about the quality of life (QoL) of caregivers of patients with chronic kidney disease (CKD) along the disease continuum. We investigated factors associated with low QoL among caregivers of patients with CKD including those on dialysis. We also examined the relationship between kidney disease severity and the QoL of caregivers.
Methods
We recruited caregivers of patients with CKD (stage 3 to 5) attending renal outpatient clinics as well as dialysis units of a tertiary hospital and patients from January 2018 to November 2023. Quality of life was assessed using a valid and reliable tool, the Adult Carer Quality of Life Questionnaire. Logistic regression analyses were performed to determine factors associated with low quality of life among caregivers.
Results
A total of 278 dyads of caregivers and patients with chronic kidney disease were studied. The mean age of caregivers and patients was 56.6 ± 15.2 and 63.7 ± 15.3 years respectively. The severity of CKD had a significant impact on QoL of caregivers in the personal growth and carer satisfaction domains where caregivers of patients on dialysis reported worse scores compared to caregivers of predialysis patients. Female gender of caregivers and patients, longer caregiving time, diagnosis of diabetes and lower socioeconomic status of patients were all associated with lower scores in one or more domains.
Conclusion
In caregivers of patients with CKD, female gender of both caregivers and patients, longer caregiving time, lower socioeconomic status and a diagnosis of diabetes among patients were independently associated with low quality of life among caregivers. An understanding of these factors provides insight into the development of targeted interventions to improve the quality of life of caregivers.
Nrf2 induction potency of plant-derived compounds demonstrated by an ARE luciferase reporter and conventional assay of NAD(P) H-quinone acceptor oxidoreductase 1 activity
Authors: Tamaru Erina , Kokubu Daichi , Ushida Yusuke , Itoh Ken
Published: April 2024

Objective
Various plants have been reported to contain compounds that promote the nuclear accumulation of Nrf2 to induce a set of xenobiotic detoxifying enzymes such as NAD(P)H-quinone acceptor oxidoreductase 1 (NQO1) via antioxidant response element (ARE). While conventional methods for evaluating the Nrf2 induction potency of compounds include NQO1 activity, recently, an ARE luciferase reporter was developed to directly assess the Nrf2 induction potency of compounds of interest. In this study, the ability of these two assays to evaluate and determine Nrf2 induction potency of plant-derived compounds was compared.
Results
Although the compounds overall showed a high degree of consistency between the assays, several compounds did not. The results suggest that although the NQO1 assay can be used as an evaluation method to estimate the Nrf2 induction potency of a compound, an ARE luciferase reporter may offer greater precision. In summary, the inconsistency in Nrf2 induction potency evaluated by the reporter and NQO1 assays for some of the plant-derived compounds evaluated herein, including resveratrol, may be due to a variety of factors that regulate NQO1 expression and activity other than Nrf2, with each compound having a different degree of effect on these factors.
Imatinib with intensive chemotherapy in AML with t(9;22)(q34.1;q11.2)/BCR::ABL1. A DATAML registry study.
Authors: Récher Christian , Gondran Camille , Dumas Pierre-Yves , BERARD Emilie , Bidet Audrey , DELABESSE Eric , Tavitian Suzanne , Leguay Thibaut , Huguet Francoise , Borel Cécile , Forcade Edouard , Vergez Francois , VIAL Jean-Philippe , Rieu.jean-baptiste@iuct-oncopole.fr Jean Baptiste , LECHEVALIER Nicolas , LUQUET Isabelle , Canali Alban , KLEIN Emilie , Sarry Audrey , De Grande Anne-charlotte , Pigneux Arnaud , Largeaud Laetitia , Bertoli Sarah
Published: April 2024

Acute myeloid leukemia (AML) with t(9;22) (q34.1; q11.2)/BCR::ABL1, a distinct entity within the group of AML with defining genetic abnormalities, belong to the adverse-risk group of the 2022 ELN classification. However, there is little data on outcome since the era of tyrosine kinase inhibitors. Among 5819 AML cases included in the DATAML registry, 20 patients with de novo BCR::ABL1+AML (0.3%) were identified. Eighteen patients treated with standard 3+7 induction chemotherapy were analyzed in this study. Imatinib was added to chemotherapy in 16 patients. The female to male ratio was 1.25 and median age was 54 years. The t(9;22) translocation was the sole chromosomal abnormality in 12 patients. Main gene mutations detected by NGS were ASXL1, RUNX1 and NPM1. No patients had detectable ABL1 mutations. Compared with patients with myeloid blast phase of chronic myeloid leukemia (CML-BP), de novo BCR::ABL1+AML had higher WBC, mutational burden, fewer additional chromosomal abnormalities, lower CD36 or CD7 expression and no ABL1 mutations. Seventeen patients (94.4%) achieved complete remission (CR) or CR with incomplete hematologic recovery. Twelve patients were allografted in first remission. With a median follow-up of 6.3 years, the median OS was not reached and 2-year OS was 77% (95% CI: 50–91). Four out of five patients who were not transplanted did not relapse. Comparison of BCR::ABL1+AML, CML-BP, 2017 ELN intermediate and adverse-risk patients showed that patients with BCR::ABL1+AML had a significant better outcome than intermediate and adverse-risk patients. This entity should not be included in the adverse-risk group of current AML classifications.
Rituximab as a Maintenance Therapy in Pediatric Patients with Frequent-Relapsing or Steroid Dependent Nephrotic Syndrome: Efficacy, Safety, and Steroid Reduction
Authors: Wu Xiaochuan , Chen Qiaoping , Cao Yan , Shuai Lanjun , Li Xiaoyan , Li Yongzhen
Published: April 2024

Background: Nephrotic syndrome is the most common glomerular disease in pediatrics. Rituximab has been shown to induce remission in nephrotic syndrome, yet the necessity and safety of its use in maintenance therapy remain uncertain. In this study, we detail our clinical experience with the application of rituximab in the maintenance treatment of pediatric nephrotic syndrome, aiming to offer an additional therapeutic option for patients.
Methods: In a retrospective study conducted at the Second Xiangya Hospital of Central South University from January 2020 to June 2023, we evaluated pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome who received rituximab treatment. All patients received induction therapy with rituximab for remission. Based on the subsequent maintenance treatment regimen, patients were divided into two groups: Group 1 (n=12) received traditional immunosuppressive therapy for maintenance, and Group 2 (n=23) received rituximab maintenance every six months. We collected and analyzed data regarding steroid discontinuation, treatment outcomes, and the incidence of adverse events.
Results: The primary outcomes measured were steroid discontinuation rate and the minimum steroid dosage required to maintain remission. Group 2 exhibited a significantly higher steroid withdrawal rate (P<0.05) and a lower minimum steroid dose for remission maintenance (P<0.05) compared to Group 1. However, the differences in steroid-free survival time (P=0.390), time to first recurrence (P=0.794), and relapse-free survival duration (P=0.199) between the two groups were not statistically significant. Adverse events were observed in both groups, with infusion reactions and infections being the most common. No serious adverse events were reported in either group.
Conclusions: In conclusion, our retrospective analysis demonstrates that rituximab maintenance therapy is an effective strategy for managing pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome. The therapy significantly increased the steroid withdrawal rate and reduced the required steroid dosage, thereby potentially mitigating the long-term adverse effects associated with steroid use. The side effects observed were acceptable.
Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice
Authors: Sabaghi Ayoob , Yousofvand Namdar
Published: April 2024

Objective Seizures during pregnancy have been linked to adverse outcomes for newborns and motor coordination (MC) defects in offspring. Physical activity has shown promise in reducing seizure severity and promoting positive outcomes for newborns. In this study, we investigated the impact of aerobic exercise during pregnancy on seizure activity in pregnant mice treated with pentylenetetrazole (PTZ) and the MC of preadolescence male mice.Methods Adult female ICR mice were divided into two groups and administered PTZ or saline for 30 days before mating. PTZ treatment continued throughout pregnancy for the experimental group, while the control group received saline. Active pregnant mice engaged in aerobic treadmill exercises from the first to the 20th day of pregnancy. MC in preadolescence male offspring was assessed using the rotarod test.Results Prenatal exposure to maternal seizures induced by PTZ resulted in MC deficiencies in preadolescence male offspring (P < 0.05). Aerobic exercise during pregnancy demonstrated beneficial effects on convulsive activity (P < 0.05) and was able to counteract the MC deficits caused by maternal seizures during pregnancy.Conclusion These findings suggest aerobic exercise during pregnancy may serve as a supplementary therapeutic approach to reduce convulsive activity and mitigate MC impairments in preadolescence male offspring.
Preparation and Performances Study of Nano-ZnO/Graphene Potassium Silicate Zinc-rich Coatings
Authors: lyu qingbo , guo feiyu , huang ziming , bai yunshan , liu huanhuan
Published: April 2024

Nano-ZnO/graphene composites were prepared and added to potassium silicate zinc-rich coatings in order to obtain Nano-ZnO/graphene potassium silicate zinc-rich anti-corrosion coatings. Their morphology and corrosion resistance were charactered by scanning electron microscopy, electrochemical testing, and salt spray testing. The effect of Nano-ZnO/grapheme contents on the anticorrosion performance of coatings was also studied. Compared to neat water-based potassium silicate zinc-rich coatings with 50wt% zinc, Nano-ZnO/graphene potassium silicate zinc-rich coating with 30wt% zinc and 1wt% Nano-ZnO/graphene has better corrosion resistance. Their water resistance and Ecorr are improved, icorr is reduced by one order of magnitude, |Z|0.01Hz is increased by six times, and Rct is increased by three times. This study indicates that Nano-ZnO/graphene not only enhances anti-corrosion performance of potassium silicate zinc-rich anti-corrosion coatings, but also improves the utilization rate of zinc powder.
Standalone methodology for building QSAR models: an antioxidant QSAR model of di(hetero)aryl amines and amides as a case study
Authors: Mateus Cristiano , Abreu Rui M.V.
Published: April 2024

QSAR modeling is a methodology used in various scientific fields to correlate molecular descriptors to the properties or biological activities of compounds of interest. Several steps are needed to construct a QSAR model, including chemical structure preparation, molecular descriptor calculation and selection, and model building and validation. We present a complete methodology for preparing QSAR models using free and open-source software tools. A detailed step-by-step protocol is provided with the complete process of QSAR modeling, from compound library preparation to statistical validation. A QSAR model was developed as a case study to model the antioxidant activity, particularly the radical scavenging activity of 70 di(hetero)aryl amine and amide compounds. The OCHEM platform was used to calculate the 12,072 molecular descriptors. These molecular descriptors and the experimental pIC50 for each compound were introduced in PyQSAR software, and a genetic algorithm was used to select four molecular descriptors to build the QSAR model: B06[C-O], Eig04_AEA(dm), JGI2 and J_Dz(p). The QSAR model was then implemented by applying multiple linear regression, and a final equation was obtained. The QSAR model presents excellent statistical parameters that verify its robustness and predictability, namely, the correlation coefficient (R2 = 0.8905), the mean score value of the MLR method (Q2CV = 0.8676) and the relative standard deviation of the residuals (RSR = 0.3320 and RSRCV=0.3518). This QSAR model will guide the synthesis of new di(hetero)aryl amines or amides with improved antioxidant activities. All files and the complete protocol are provided to replicate the building of the presented antioxidant QSAR model, and researchers will be able to prepare other QSAR models using different compound libraries and different biological activities.
The predictive value of contrast-enhanced ultrasound combined with ultrasonic elastography in response to neoadjuvant chemotherapy in different molecular types of breast cancer
Authors: Wang Yanjuan , Jiao Huajie , Han Tao , Yang Guangfei , Ke Qinglan , Zhang Qian , Wang Fuxia
Published: April 2024

Objective: To investigate the predictive efficacy of contrast-enhanced ultrasound (CEUS) and elastosonography (ELA) in adjuvant chemotherapy in patients with different molecular types of breast cancer.
Methods: 74 patients with breast cancer from June 2021 to August 2023 were divided into Luminal A group, Luminal B group and human epidermal growth factor receptor 2 (HER-2) group according to molecular typing. All patients underwent neoadjuvant chemotherapy treatment and were divided into a reactive group (n=61 cases) and a non reactive group (n=13 cases) based on the treatment effect. All patients underwent contrast-enhanced ultrasound and ultrasound elastography (using shear wave elastography (SWE) mode) examination, and ROC curves were plotted to analyze the combined predictive performance of contrast-enhanced ultrasound and ultrasound elastography.
Result: There was no statistically significant difference in the parameters of contrast-enhanced ultrasound and ultrasound elastography between the Luminal A group, Luminal B group, and HER-2 group (P>0.05); The parameters of contrast-enhanced ultrasound and ultrasound elastography after chemotherapy in breast cancer with different molecular types were lower than those before chemotherapy (P<0.05); Among 74 patients with breast cancer, 13 (17.57%) were non responsive to neoadjuvant chemotherapy. The PT, K1, and SR of the non reactive group were higher than those of the reactive group (P<0.05); The ROC curve results showed that the combined examination of contrast-enhanced ultrasound and ultrasonic elastography was more effective than the single examination in predicting the response to neoadjuvant chemotherapy in patients with different molecular types of breast cancer (P<0.05).
Conclusion: When breast cancer patients are treated with neoadjuvant chemotherapy under different molecular classifications, the indexes of contrast-enhanced ultrasound and elastography have changed before and after chemotherapy, and the combination of the two has a high predictive value for different molecular classifications of breast cancer, which can obtain high sensitivity and specificity, and can provide a reliable basis for the formulation and adjustment of adjuvant therapy programs.
Dynamic Analysis of Pre-Stressed Concrete Girder Bridge Using Csibridge Software
Authors: Das Soumya Suhreed , Das Joyonta Chandra , Rahman Md. Sifur
Published: April 2024

Bridges are crucial transportation components that must be able to withstand seismic events to ensure public safety. Prestressed concrete bridges are commonly used, but their behavior under seismic loading conditions needs to be thoroughly studied. The research intends to investigate how bridges respond to seismic activity by utilizing the powerful FEM tool known as CSiBridge software, and aims to improve design methods and guidelines, enhance performance, and identify potential vulnerabilities and failure modes during earthquakes. As a result, a detailed design of a prestressed concrete bridge model was developed and examined throughout this study. The bridge under study has three 90 feet spans with a total width of 35 feet with four AASHTO-PCI BT-63 bulb-tee Precast Beams on thick cast-in-place. concrete deck Abutments are positioned at each end of the bridge. Verification of bridge superstructure components using the AASHTO LRFD code reference and the bridge modeling process using verified components through CSiBridge software was completed. Detail seismic design, including modal, pushover, and response spectrum analyses, was prepared for conduction on the model. Analyzing the entire model, including construction, materials, properties, and location-specific seismic conditions, constitutes the final step.
Evaluation of the relationship between time management and professional self-efficacy with quality of nursing care in nurses of northwest Iran
Authors: KhalilzadehZia Sana , Mohamadi MohammadAli , Zadeh Mehdi Mahmoud , Dadkhah Behrouz
Published: April 2024

Aims The present study aims to evaluate the relationship between time management and professional self-efficacy with the quality of nursing care in nurses of northwest Iran.Background Nowadays time is a vital factor in medical interventions. Time management and self-efficacy are crucial for retrieving the best nursing care standards.Methods This correlational study was conducted in Ardabil, northwest of Iran, in 2023. In these 350 nurses have been categorized by stratified sampling method. For data collection, we used Raj’a Nayef Zyoud's(2023) time management inventory, Masoumeh Bakhtiari et al(2023) professional self-efficacy of nurses inventory, and Anita Karaca et al(2022) nursing care quality inventory. The collected data were analyzed in SPSS software (26) using descriptive statistics, independent t-test, analysis of variance, Pearson correlation coefficients, and linear regression stepwise model.Result The results revealed that Time management (80.3%), Professional Self-efficacy (61.7%), and Quality of nursing care (57.1%) were at a moderate level. Also, the mean value of the time management score, professional self-efficacy score, and nursing care quality score were (59.79 ± 10.37), (72.64 ± 12.34), and (45.151 ± 16.78), respectively. There was a meaningful relationship between time management and professional self-efficacy with the quality of nursing care (p < 0.001). The stepwise multiple linear regression model showed that time management (65%) was a stronger predictor than professional self-efficacy (62%) on the quality of nursing care.Conclusion contributing nurses in this study had shown a medium level of nursing care. We suggest that medical politicians conduct workshops to upgrade time management skills and the professional self-efficacy of nurses so that the quality of nursing care improves as well.
A study on the privacy dilemma overcoming method of voluntary personal information leakage in relational SNS: data-based privacy leakage risk score development
Authors: Bae Hyunjin , Cha Kyungjin
Published: April 2024

The advancement of internet technology has facilitated the emergence of relational Social Network Services (SNS), offering services based on individuals' social connections. SNS users utilize personal information as a means of self-expression, thereby constructing their own social networks. However, the proliferation of personal information breaches has emerged as a significant contemporary concern due to the escalating use of SNS platforms. Recent incidents predominantly involve the collection and dissemination of information voluntarily disclosed on SNS, rather than by hacking. Despite the imperative need to forestall such breaches, there is a dearth of empirically applicable methodologies to gauge the risk of personal information leakage. Prior research methodologies for quantitatively assessing breach risk have predominantly concentrated on evaluating personal profiles alone, with limited consideration given to the potential identifiability of personal information embedded within uploaded content. Furthermore, these studies have often relied on surveys to ascertain users' perceptions of personal information leakage risk, hereby constraining their practical applicability and difficult to fulfill the objective of preventing personal information breaches. Hence, this study proposes a method for estimating privacy leakage risk based on the privacy-dilemma framework, which underscores the dilemmas SNS users encounter in managing both personal profiles and content data. Leveraging Social Network Analysis (SNA) to capture the nuances of relational SNS characteristics, we aim to enhance methodologies proposed in previous studies. The Multiple Regression Quadratic Assignment Procedure (MR-QAP) analysis is employed to delineate the factors influencing the risk score. This methodological approach holds promise in furnishing practical insights into privacy protection.
Unlocking the potential of Euglena gracilis cultivated in piggery wastewater: biomass production, nutrient removal, and biostimulant potential in lettuce and tomato plants
Authors: Butzke Valéria Louzada Leal , Ferreira Alice , Corrêa Diego Oliveira , Furlan Júnior Mendes , Gouveia Luisa , Schneider Rosana de Cássia de Souza , Corbellini Valeriano Antonio
Published: April 2024

Microalgae are increasingly recognized as a valuable resource for bolstering sustainability in agriculture. Yet, current research often overlooks the diversity of microalgae species. Euglena gracilis (Euglenophyta) is a microalga renowned for its resilience to diverse environmental stressors and capability to produce a variety of bioactive metabolites. This study investigated the potential of cultivating E. gracilis in piggery wastewater for nutrient recycling and as a source of beneficial biomolecules, particularly for biostimulant use. Utilizing raw wastewater diluted to 25% (P25) and pre-treated wastewater with photo-Fenton (PF), the research found that E. gracilis exhibited elevated cell density, biomass concentration, and overall cell health in both wastewaters compared to a synthetic medium (BG11-NPK). This was due to its efficient removal of nutrients, especially ammoniacal-nitrogen and phosphate, resulting in a biomass rich in polyunsaturated fatty acids, amino acids, and paramylon content. The whole-cell biomass significantly enhanced the germination index of lettuce and tomato seeds compared to the water control. Additionally, it promoted cell expansion and root formation in cucumber cotyledons, exhibiting similarities to phytohormones such as gibberellin, cytokinin, and auxin. Furthermore, it is suggested that E. gracilis biomass contains molecules related to resistance to environmental stresses, particularly in tomatoes, given the enhancement in the seedling vigor index. E. gracilis exhibited remarkable adaptability to piggery wastewater, recycling nutrients and yielding biomass rich in bioactive molecules with potential as plant biostimulants. These findings significantly contribute to understanding E. gracilis's potential applications in agriculture and developing a circular bioeconomy.
High-voltage pulse generator based on LTD concept for CuBr+Ne+HBr laser media excitation
Authors: Semenov Konstantin Yu. , Gembukh Pavel I. , Trigub Maxim V.
Published: April 2024

The paper presents the power supply based on the LTD-generator concept for active elements on metal halide vapors excitation. The main source feature is the modular structure which allow to increase output voltage and change storage capacity due to the number of modules. Each module is designed to minimize parasitic parameters and provide high voltage and current slew rates to the GDT. The limit parameters of one module are as follows: maximum voltage 1100 V, maximum pre-pulse energy in the storage capacity 9.0 mJ. The results of the excitation of the active media at the different pulse repetition frequency are presented. For the first time the 1.5 W radiation power was obtained for the laser excited by this type of power supply.
Psychometric properties of the Arabic Spence Children’s Anxiety Scale- Parent in a non-clinical sample of Arabic-speaking adults
Authors: Milane Mia-Joe , Chahine Abdallah , Malaeb Diana , El-Khatib Sami , Dabbous Mariam , Sakr Fouad , Fekih-Romdhane Feten , Hallit Souheil , Obeid Sahar
Published: April 2024

Background
Anxiety, characterized by an unpleasant state of anticipatory unease, manifests in approximately 19% of adolescents and children within the Lebanese population. The diagnostic challenge in pediatric populations often stems from parental reluctance to acknowledge potential mental health concerns. Various screening instruments, including the Spence Children’s Anxiety Scale (SCAS), aid in identification of anxiety, yielding the necessity of validation of the scale in the Arabic language. This study aims to validate the SCAS-Parent in Lebanon, assessing reliability, validity and consistency of the scale.
Methods
This cross-sectional study enrolled adults parents from all over Lebanon. The data was collected through a Google form and using snowball technique during November 2023. The questionnaire included sociodemographic data, the Brief version of the Spence Children's Anxiety Scale for the Parents (SCAS-P-8) and the Depression Anxiety Stress Scale (DASS-8).
Results
Confirmatory factor analysis indicated that fit of the one-factor model of the SCAS-P-8 scale was acceptable: χ2/df = 84.53/20 = 4.23, RMSEA = 0.080 (90% CI 0.063, 0.098), SRMR = 0.035, CFI = 0.966, TLI = 0.952. The standardized estimates of factor loadings were all adequate. The reliability of the scale was good (ω = 0.90 / α = 0.90). Higher parental depression (r = 0.61; p < 0.001), anxiety (r = 0.62; p < 0.001) and stress (r = 0.48; p < 0.001) were significantly associated with higher anxiety in the child.
Conclusion
The study validates the SCAS-P-8 for its application in the Lebanese population, demonstrating high internal consistency, reliability, and validity, indicating its potential as a screening tool for anxiety in children in the hands of psychologists and health-care professionals. Anxious parents will most likely have anxious children, leading to a viscous cycle. Early screening of anxiety in children can potentially impact the quality of life, life choices and developmental status of children.
Transformation of Digital Technologies in Local Government
Authors: Sharkov F. I. , Miller D. G.
Published: April 2024

There is little theoretical justification for integrated management in municipalities. This especially concerns the need to formulate the concept and use of digital technologies for municipalities at various levels. This implies the need to take into account the core values characteristic of public organizations, in particular public associations and individuals involved in this process. The problem of digitalization has been considered in many areas, but at the municipal level there are only the results of fragmentary descriptions, and, most often, only at the level of converting previously created content into digital format. The authors show various approaches to the use of digital technologies in management: e-government, digital city, smart city, digital projects in municipalities, digitalization of administration, information and communication technologies in state and municipal government. This study examines a rarely considered aspect, namely the transformation of digital technologies in the management process at the city level, as well as its impact on urban infrastructure assets. Besides, the study attempts to methodize the objects of the municipal structure in a digital format and to attract the attention of the practical world to the value that a complex development system integrated into digital space can bring to the system.
The Opinion of Russian Journalists on Professional Standards in Traditional and Digital Media
Authors: Litvinova A. I.
Published: April 2024

The field of journalism in Russia is undergoing continuous transformation influenced by the intricate political and legal landscape, as well as the dynamic advancements in technology and resulting social shifts. These changes disrupt established professional norms, roles, values, and practices within the journalism community. These changes disrupt established professional norms, roles, values, and practices within the journalism community. The discussion surrounding professional journalistic standards is not only prompted by the aforementioned factors but also by the gradual integration of AI technologies into everyday journalistic practices. Against this background, the author conducted a study based on 11 semi-structured interviews with the representatives of the professional community and devoted to the issues of professional identity of journalists, the boundaries of the profession and the transformation of professional standards. The study showed that despite some discrepancies in viewpoints, professionals emphasize the paramount importance of clearly defined “rules of engagement” that are comprehensible to both the journalism community and its audience. While core values remain largely unchanged, practical aspects such as formatting requirements and acceptable journalistic practices demonstrate adaptability to shifting socio-political, economic, and cultural contexts. Notably, values are consistent across traditional and new media platforms, whereas technical and practical standards exhibit greater flexibility and responsiveness to evolving norms. Ultimately, the specific standards adopted by individual editorial teams are contingent upon the media format and niche they occupy within the industry.
Potential of Digital Technologies in Election Campaigns
Authors: Minaeva L. V.
Published: April 2024

Currently, the active introduction of digital technologies into the field of political communication has led to a transformation of electoral discourse structure. Big data analysis techniques are widely used at the preparation stage to identify the target electorate; at the communication stage, machine learning technology helps to pinpoint fakes and monitor the media, and neural networks create campaign content. Digital technologies enable actors in the political process to communicate with the electorate through channels independent of mainstream traditional media, densify the information environment and contribute to the creation of a unique digital scenography that produces a powerful emotional impact on the electorate. The article examines the most active period of the election campaign, when the candidate is in direct contact with the electorate, and digital technologies enhance the degree of his/her influence on potential voters. It is shown that the choice of digital technologies depends, to a large extent, on the political culture of the country. The cases of election campaigns in the USA, France, India and South Korea are considered.
Evaluating the quality and nutritional content of bottled waters in Algeria
Authors: Tamrabet Lahbib , Sekiou Fateh , Tamrabet Selsabil
Published: April 2024

The present study offers a quality assessment of the mineral and spring waters marketed in Algeria within the national and international legislations, examine the potential contribution of bottled waters to essential elements intake and effects on public health based on empirical, graphical tools, multivariate statistical techniques and (DRI) system. The study covered a dataset of 30 mineral and 33 spring brands. The parameters included, from bottle labels, were of physicochemical nature. All brands comply with national and WHO norms for the bottled waters, except for (Brand#63) in which NO2− exceeded the maximum permissible limit for mineral water and (Brands#4 and #21) where TH and TDS exceeded the Algerian recommended guidelines for spring water. Nearly 5% of the total brands were of bicarbonate nature belonging to mineral water, while 25% of all brands were suitable for low-sodium-diet. PCA and HCA showed that bottled waters could be classified into two distinct groups, according to degree of mineralization. The DRI-system revealed that Algerian bottled waters contributed substantially to the daily intake for Mg2+ with up to (63%), Na+ (40.36%) and Ca2+ (36%) for spring water for different ages and genders, whereas mineral water exceeded the maximum recommended daily intake for Ca2+ (128%) and Na+ (148.36%) for adults.
Reducing costs of Giardia spp. cyst enumeration using machine learning-based systems
Authors: Belini Valdinei Luís , Fava Natália de Melo Nasser , Sabogal-Paz Lyda Patrícia
Published: April 2024

Giardia spp. cyst enumeration is a laboratory procedure that is frequently required in water treatment-related research. Currently, detection conducted by experts using fluorescence microscopy on samples stained with specific markers for Giardia spp. cysts is still the standard method, despite its high costs limiting its usage worldwide and, ultimately, hindering waterborne analyses in low-income countries. We present an approach based on darkfield imaging and machine learning to reduce costs associated with Giardia spp. cyst enumeration and the lack of experts. Automated counts were compared to manual counts, achieving an average sensitivity (SE) rate of 88%, specificity (SP) of 100% and accuracy of 88% across a wide range of cyst concentrations. By using machine learning in conjunction with darkfield microscopy, a low-cost illumination technique that can be easily integrated into standard laboratory microscopes, we have significantly reduced the costs associated with Giardia spp. cyst detection, all while still maintaining the SE and SP of fluorescence microscopy. Based on the findings, the proposed system has the potential to be a useful tool to enumerate Giardia spp. cyst suspensions. It can be accessed by virtually any microbiology laboratory as it is consumable-free and expert-independent.
Comprehensive evaluation and analysis of water resource characteristics in Lixiahe Plain, China
Authors: He Liang , Yang Liwen , Chen Ling , Ye Yabin , Zhang Shuo , Xu Chenfang
Published: April 2024

Lixiahe Plain's local water resources need to be evaluated effectively and comprehensively. This study is based on the multisource data from 60 natural water samples, 16 rainfall monitoring stations, and 2 evaporation monitoring stations from 1965 to 2020. Synchronous series representativeness analysis, water quality analysis, and water resource availability estimation are conducted to analyze the spatiotemporal distribution characteristics of rainfall, evaporation, and water quality and calculate the availability of various types of water resources. The results indicate that the spatiotemporal distribution of rainfall and evapotranspiration in the study area is uneven, which increases the threat of local floods and droughts. The quality of the main rivers and lakes in the region is good, and the water quality of the drinking water source area and groundwater reaches and even exceeds Class III water standards. In the year 2020, the total water usage in the research area reached 341 million m3. However, the available sum of surface water resources and transit water availability in 2022 was only 201 million m3, so local water supply needs cannot be easily met. Exploring the water resource characterization model of the Lower Rivers Plain can help in local water resource management and protection.