bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelindungan Hukum Hak Cipta Terhadap Reini Wirahadikusumah Sebagai Orang yang Menjadi Objek dalam Karya Cipta Potret yang Diunggah Tanpa Izin Sebagai Aset Digital Non-Fungible Token (NFT)
Authors: Batara Siahaan Gibson , Rafianti Laina , Haffas Mustofa
Published: May 2023

Currenct technological developments support humans to be able to carry out economic activities without regional boundaries problems. One of the impacts is the Non-Fungible Token (NFT) technology that supports security in investement activites of copyrighted works that are converted into digital assets on digital platforms. However, the platform is also used by the irresponsible parties as a medium for copyright infringement, such as in the case of unauthorized sale of Reini Wirahadikusumah’s potrait as Chancellor of ITB on the OpenSea platform. This study aims to understand the legal protection related to the rights of Reini Wirahadikusumah as the person in the potret work and the appropriate legal action taken by Reini Wirahadikusumah for the illegal sale of the potrait work.
STEM Education and the Water Management. An Entrepreneurship Initiative
Authors:   Politehnica University Timişoara, Mirea Nicoleta , Bogdea Constantin Florin ,   Politehnica University Timişoara, Oroian Irina ,   Politehnica University Timişoara
Published: May 2023

The aim of the paper is to establish the current state of a new STEM (Science – Technology – Engineering - Mathematics) learning method concerning entrepreneurship towards different ages of students by evaluating the situation of water sustainability. Based on the findings of the study, the new and the old one, we could be able to develop a motivational program taking into consideration all the key findings and suggest policies and initiatives that could empower and enhance them to keep clean water. The analysis will be fundamental to develop entrepreneurial competences taking into consideration exchange of good practices project also.
"Challenges for the Future of the Legal Profession in Romania"
Authors:   Politehnica University Timişoara, Metzler Mirabela , Luminosu Caius Tudor ,   Politehnica University Timişoara
Published: May 2023

Innovation drives change in many aspects of life, but the particularity of legal services must be considered when making changes, in order to satisfy the need to innovate and maintain professional standards. The research is focused on observing regulatory requirements, the economic aspects of legal activities and deontological issues that arise from practicing law in Romania. Besides the interdisciplinary analysis (European Union legal framework, national legislation) and multidisciplinary approach of the concept of legal services market (from the perspective of economics, deontology and regulations) the paper addresses national bibliographic deficiencies with numerous references of legal developments in other countries. The aim of this study is to prepare for innovation by discussing global trends and professional challenges that the legal profession is facing in Romania.
Early school leaving, a problem of the entire society
Authors:   Politehnica University Timişoara, Pușcaș Corina - Diana , Andrasy Bianca - Varvara ,   Politehnica University Timişoara
Published: May 2023

Education is one of the main pillars of a society that supports the development of a country by being a basic tool in achieving a sustainable future. In our country the institutionalized education suffers, because of the instability of specific legislation, frequent changes in the curricula. Another cause of instable educational system is the social inequality, which is also a main driver for early school leaving. Moreover, the evolution of technology (tools, internet etc.) and current society changes are factors that deepen the social disparity phenomena and determine certain behaviors among young people.
The Obligation of Establishment of Governance and Civilian-Non Theocratic Nature of Government in Islam
Authors: Dr. Lateef KayodeADEYEMO  , Sirajudeen Femi BAKRIN
Published: May 2023

Governance is a religious obligation in Islam in order to maintain law and order, cater for the welfare of people, ensure justice and fair play and facilitate observance of religious duties, as religion could only be practised and practised well in an atmosphere of peace. By religious duties, we should not be mistaken for prayer, Islamic tax (charity), fasting, and pilgrimage alone as worship or devotional duties in Islam ramificates every aspect of a Muslim life. It includes and covers everything a Muslim could do to please his Lord-including good governance which is the hallmark of Islamic governance or political system. However, as important and as obligatory governance is to Islam, government is civilian – and not a theocratic- institution. Although, the Religion of Islam as well as the Holy Scripture, the Qur’an, which encapsulates or embodies its teachings, is Divine, yet their interpretations and implementations are human. This interpretation and implementation which forms the explanation/understanding (fiqh/fahm) of the law (shari’ah) are meant to guide Muslims in the proper understanding of their rights and duties not only to Allah but from and to their fellow human beings. Hence Islamic governance system is theo-communocentric rather than being just theocentric. Although, the basics remain unchanged, these interpretations are affected by the prevailing circumstances of a given time and clime, popularly referred to by scholars as fiqh waq’in. Thus, individuals are responsible for whatever interpretation and implementation they make of the law. Suffice to say therefore, that one of the reasons why governance is obligatory in Islam is, to maintain unity and universality of Islam and to ensure peaceful co-existence, albeit peaceful society where the practice of religion is encouraged and facilitated. This paper therefore, tries to examine why the establishment of governance is obligatory and why government is civilian and therefore theo-communocentric rather than being theocratic in Islam.
Penerapan Nilai-Nilai Islam dan Hubungannya dengan Perubahan Sosiobudaya Masyarakat Islam di Brunei Darussalam
Authors: Dr. Dyg Hajah Ummi Fa’izah Bt Hj.Abdul
Published: May 2023

Borneo yang kaya dengan bahan mentah dan pelabuhan perdagangan yang strategik di Alam Melayu telah menarik minat orang-orang Eropah termasuk British dan Belanda untuk melebarkan kuasa jajahan mereka. British telah menakluki bahagian utara Borneo iaitu Brunei bermula pada awal tahun 1774, apabila wakil dari Engish East India Company (EEIC), John Jesse datang ke Brunei untuk membuka rundingan berkenaan dengan lada hitam. Bermula detik perkenalan itu, hubungan Brunei dengan British berterusan di abad 19 sehingga Brunei mencapai kemerdekaannya pada tahun 1984, iaitu 210 tahun kemudiannya. Walaupun, kedatangan British ke Borneo tujuan utamanya ialah politik dan perniagaan, tetapi secara langsung turut menyekat perkembangan Islam disana. Namun, bermula tarikh kemerdekaan Brunei pada 1 Januari 1984, masyarakat Brunei mula melakukan perubahan sosiobudayanya apabila Sultan Brunei mengisytiharkan Brunei sebagai Negara Melayu Islam Beraja yang Merdeka, Berdaulat dan Demokratik bersendikan Ajaran Agama Islam. Ini bermakna, Islam itu bukan hanya sebagai cara hidup yang lengkap tetapi menjadikannya sebagai kemudi, dasar dan falsafah Negara Brunei Darussalam. Penerapan nilai-nilai Islam mula dilaksanakan melalui Kementerian Hal Ehwal Ugama Brunei. Dengan penerapan nilai-nilai Islam tersebut berlaku beberapa perubahan sosiobudaya dalam masyarakat Islam di Brunei seperti dalam kepercayaan dan aqidah, adat, politik, ekonomi, sosial dan pendidikan. Secara keseluruhannya dapat disimpulkan bahawa dengan dasar penerapan nilai-nilai Islam, masyarakat Brunei mengalami perubahan sosiobudaya.
Issues of Halal Products Containing Alcohol with Reference to Regulations in Brunei Darussalam
Authors: Siti Nazerah A. Hanni/Zalanni  , Zeaid Amjad Aghwan
Published: May 2023

Alcohol is considered to be synonymous with intoxicant (al-khamr), which is strictly prohibited in Islam. However, this perception appears to be misleading as alcohol was also used as a common ingredient in the halal industry. This study aims to decipher the issues of halal products concerning regulations in Brunei Darussalam. The three objectives are: firstly, is to determine the meaning of khamr, alcohol and ethanol and also their application in the halal industry. Secondly, is to find out the issues about halal products containing alcohol. Thirdly, is to study halal regulation of Brunei Darussalam in matters related to the use of alcohol in products. To achieve the objectives, both qualitative and quantitative methods have been adopted for data collection. Data has been collected using primary data sources such as structured interviews and surveys, and also previous findings from the secondary source. Major findings revealed two important points on the issue of halal products containing alcohol. First of all, the analysis of a survey conducted on the issue of alcohol from 165 respondents, found that Muslim consumers in Brunei Darussalam are found to have a piece of excellent knowledge of the basic rulings of alcohol and khamr. However, they are found lacking in terms of the application of naturally produced and synthetic alcohol in the halal industry. Secondly, it was found there is a lack of global halal regulations among MABIMS countries in terms of determining the usage of alcohol in the halal industry. From further analysis, it can be deduced the source for this issue is due to 1) the methodology in issuing a fatwa, and 2) scientific-related reasons. To solve these issues, some suggestions are proposed which mainly involve the intensification of spreading awareness on halal issues to the public masses in Brunei Darussalam.
Halal Policy in Brunei Darussalam
Authors: Noryati Haji Ibrahim
Published: May 2023

Consumption of Halal is the commandment of Allah SWT as explained in the Quran and Sunnah, which aims to preserve the Maslahah of the people in accordance with the principles of Maqasid Shariah. Therefore, Allah SWT prohibits certain types of food simply because of the harm it causes to humans physically, mentally, spiritually and morally. In Brunei Darussalam, halal matters control and monitoring are highly emphasized. This can be seen in various contexts, especially in the titah or proclamations of His Majesty the Sultan and Yang Di Pertuan Negara Brunei Darussalam who repeatedly asserted the control of halal products and goods in this country is guaranteed and Shariah-compliant. In addition, in the context of Negara Brunei Darussalam as an Islamic country and the adoption of the Concept of Malay Islamic Monarchy (MIB) as a national policy also demonstrates the importance of halal in the country. The enforcement of two halal legislation further strengthens the halal control efforts as well as the role of other legislation governing the safety and quality of food.
Web Application Using HTML, CSS, Java script and Java
Authors:   Department of Mechatronics Engineering, Dr. Mahalingam College of Engineering and Technology, Pollachi, Tamil nadu, India., S Sanjay Kumar , M Giridharadhayalan
Published: May 2023

This paper presents the development of a web application for online clothing sales using Java, Postgre SQL, and AJAX. The web application includes an admin dashboard, product page, cart page, login and sign-up page, landing page, and orders page. The project aimed to provide a user-friendly interface and a secure, efficient system for buying and selling clothes online. The web application was developed using servlets, JSP, HTML, CSS, JavaScript, and Postgre SQL database management system. AJAX was also employed to enhance user experience by enabling dynamic updates of web pages. The study discusses the methodology used for the development of the web application, including system analysis and design, database design, user interface design, and implementation. The results demonstrate the successful development of a reliable, efficient, and secure web application for online clothing sales. The application can help clothing businesses improve their online presence and reach a broader audience. Key Word: E-Commerce Web Application; HTML,CSS,JS,JAVA
Helmet and Number Plate Detection and Recognition
Authors:   Babu Banarasi Das Institute of Technology and Management, Uttar Pradesh (Lucknow), India., Pandey Adarsh , Shanker Mahima , Rai Devanshu , Ahmed Farhan
Published: May 2023

Today, motor cycles are the most popular means of transportation. Cyclists and Passengers using helmets. This paper uses image processing techniques that motor cycles use to ride without helmets. Recognized. This project recognizes moving vehicles based on input as images or videos, Categorize motor cyclists and non-motor cyclists based on background removal and image size Recognized. If the vehicle detects that the motor cyclistis not wearing a helmet, the vehicle details the person. Vehicles and license plates are captured in the form of images. Algorithms are designed to recognized ig its A motor cyclist's signature from an image or video captured by a camera. License plate recognition has an algorithm Various steps such as vehicle classification, pre processing, ROI (Region of Interest) selection, and detection Sign the license plate using an image processing algorithm and store the image in a database. Evidence with the date and time recorded. A database is created with the evidences to redin relation to the crime Accurately identify each criminal ,arrest the suspect's vehicle and use it to fine them The system uses pure machine learning to identify different helmet types encountered minimal cost. Key Word: motorcyclists without helmet, number plate recognition, Machine Learning, Artificial Intelligence, image processing.
Access Control and Voice Response in IoT Based Home
Authors:   Department of Mechatronics Engineering, Dr.Mahalingam College of Engineering and Technology, Pollachi, Tamilnadu, India., CR Vaidheeswaran , S Varunesh , S Adhi Vishnu , C Radhakrishnan
Published: May 2023

The goal of this project is to design a smart phone application-controlled home automation system. The system will monitor and manage several elements of the house, including lighting, and security, using a combination of sensors, microcontrollers, and communication protocols. The system will be created to be user-friendly, secure, and economical with energy. Users will be able to establish routines, get notifications, and remotely operate and monitor their house via the smart phone app. To further improve the system's functioning, the study will investigate the integration of voice assistants and machine learning techniques. The ultimate objective of this project is to develop a complete home automation system that offers its consumers comfort, convenience, and peace of mind. Keywords: Access control system Home automation, Microcontrollers Node MCU, Voice assistants.
La complexe intégration professionnelle des femmes algériennes, entre avancées et résistances : le cas du groupe Cevital
Authors: HOUANTI L’Hocine , DANG Rey , SCOTTO Marie José , GUECHTOULI Manel , Boyer André
Published: May 2023

Ce travail exploratoire représente la première étape d’un projet plus global d’étude de l’intégration des femmes algériennes dans les entreprises de leur pays. A partir d’une étude de cas, cette recherche vise à mon-trer la complexe intégration des femmes algériennes dans les entreprises, malgré des niveaux de formation élevés, sanctionnés par des diplômes de l’enseignement supérieur. Ce premier article présente le groupe Cevi-tal et analyse la démographie de sa force de travail et la position des femmes dans l’entreprise.
La RSE dans le contexte africain : quelles pratiques dans le secteur minier ? Cas de la République de Guinée
Authors: DIALLO Laouratou
Published: May 2023

L’émergence et la multiplication des revendications à l’égard de l’industrie minière, au cours des dernières décennies, pose de plus en plus la question de la légitimité des activités minières en particulier dans les pays en développement. En effet, l’industrie minière est aujourd’hui présentée comme l’une des plus destructrices au monde, compte tenu des externalités négatives qu’elle génère sur l’économie, l’environnement et la société en général. Cette remise en cause systématique a entrainé une mobilisation des parties prenantes au premier rang desquels figurent les opérateurs miniers et la Banque Mondiale, pour une transition progressive du secteur vers le développement durable. Dans les pays d’Afrique Subsaharienne riches en ressources minières, les initiatives dans ce sens foisonnent malgré leur caractère fortement disparate, au gré des compagnies minières constituées en grande majorité de firmes multinationales. Dans ce contexte, l’objectif du présent article est d’aborder la question relative aux enjeux de la transition du secteur minier vers le développement durable dans les pays d’Afrique Subsaharienne, à travers l’analyse du degré d’appropriation et d’intégration des concepts de développement durable et de RSE par les compagnies minières en activité en République de Guinée.
Proceso de Revinculación Familiar en Clínica Psicológica Universitaria: Perspectiva de Terapeutas Familiares
Authors: Galdámez Del Valle Romina , Soto Ramos Maria Teresa , López Orellana Patricia , Baos Manosalva Marcelo , Alarcón - Espinoza Marina
Published: May 2023

Ante situaciones de divorcio o separación conflictiva, muchas veces los hijos se desvinculan de alguno de sus padres. Desde el interés superior del niño, observando la necesidad de vinculación de los hijos, con ambos padres y sus familias extensas, se investigó el proceso de revinculación familiar realizado por 5 terapeutas familiares de una Clínica Psicológica Universitaria, a partir de la derivación del Tribunal de Familia. Con una metodología cualitativa y un diseño descriptivo, se utilizó la entrevista individual focalizada con contrachequeo y la entrevista grupal, como técnicas de recolección de datos. Dentro de los resultados, se identificaron dos núcleos centrales de contenido: Proceso de intervención y Reordenamiento de las relaciones del sistema familiar, a partir de lo cual, se sistematiza en un flujograma el proceso de revinculación familiar, indicando fases, criterios y/o objetivos. Se discuten los resultados confirmando la concordancia con aspectos conceptuales; se observan las resistencias del adultos respecto del proceso de revinculación y en especial las asociadas al adulto vinculado, siendo necesario fortalecer los lazos de confianza mutua, y el necesario abordaje de sintomas psicopatológicos que pudieran presentarse en alguno de los miembros de la familia. Se destaca el ejercio reflexivo llevado a cabo por los terapéutas al observar sus prácticas y la necesidad de mantener estos espacios como un deber ético.
Mediating effect of autistic traits between the emotional impact of pandemic and depressive symptoms.
Authors: Jodra Chuan Marina , García-Villamisar Domingo
Published: May 2023

Background. The pandemic is having a significant impact on mental health, especially in vulnerable groups.
Method. A conditional analysis was carried out with a population of 185 people. The study population did not have any psychiatric diagnosis, they are people without autism. The age of the participants ranges between 18 and 72 years (M = 31.43; SD= 16.26). The mediating role of autistic traits and the moderating role of age between the emotional impact of the pandemic and depressive symptoms are analyzed. Results. The results demonstrate a significant influence of age and emotional impact of the pandemic on the depressive symptoms. The mediating variable autistic traits was also significant. Conclusions. These results point to the younger population with autistic traits as particularly vulnerable
Antisocial and Criminal Behaviors of Secondary School Students from the city of Chihuahua in Northern Mexico and Associated Risk Factors
Authors: Monárrez-Espino Joel , León-Ramírez Christian Lucero , Vázquez-Ríos Miriam Edith , Montes-Meléndez Damaris , Ávila-Carrasco Lorena , Martínez-Fierro Margarita , Vaca-Cortés Jesús
Published: May 2023

Background: Since the school is a key setting during adolescence, it is crucial to detect deviant social behaviors of individuals in this environment to target corrective measures. Aim: To estimate the prevalence of antisocial and criminal behaviors of secondary school students in the city of Chihuahua, northern Mexico, and to explore associated factors. Methods: Cross-sectional survey with adolescents aged 13-16 years, randomly selected from public and private schools. The Mexican version of the validated antisocial and criminal behaviors questionnaire was applied to 430 students from 41 schools. Proportions and mean scores were computed. Results were stratified by individual and school characteristics. Logistic regression was used to identify factors associated with the probability of reporting at least one criminal behavior. Results: Eating when not allowed (67.5%) and arriving late to school (51.7%) were the most frequent antisocial behaviors, while spending money gambling (17.2%) and damaging objects or property in public spaces (15.5%) were the most frequent criminal behaviors. Men had a higher criminal mean score (1.35 vs. 0.89; p<0.05), and 9th graders had higher mean than 7th and 8th graders for antisocial (7.05 vs. 5.39 and 4.97; p<0.05) and criminal (1.44 vs. 0.98 and 0.94; p<0.05) behaviors. Public schools had a lower antisocial mean than the private (5.52 vs. 6.61; p<0.05). High-income private schools had the highest mean for antisocial behavior (7.44), followed by tele-secondaries (7.06); for criminal behavior, public technical (1.71) and tele-secondaries (2.31) had the highest means. The schools’ lowest academic performance was associated with lower means, especially for criminal behavior. Male sex, higher school grade, low school performance, having failed a year, reporting family problems, and performing specific free-time activities (e.g., hanging out with friends) were associated with a higher adjusted odds ratios of reporting at least one criminal behavior. Conclusion: The most frequent behaviors were quantified, and specific risk groups and factors were identified in order to design and implement preventive programs
The Association of Grief with Mental Health and the Role of Loneliness During the COVID-19 Pandemic
Authors: Benítez-Manzanas Laia , Feixas Guillem , Gabarrell-Pascuet Aina , Domènech-Abella Joan , Mortier Philippe , Vilagut Gemma , Haro Josep Maria , Alonso Jordi
Published: May 2023

Previous research found that bereavement is associated with several pathological responses affecting both physical and mental health. During the COVID-19 pandemic and the socially disruptive measures implemented, losses of close contacts have occurred under exceptional circumstances, and it is reasonable to expect that many bereaved people would be unable to overcome their loss adaptively, resulting in dysfunctional grief leading to mental health alterations. Loneliness, which has increased during the pandemic, has been identified as a significant risk factor for mental health that is common when people grieve. In this study, we aimed to gauge the effects of bereavement on mental health in the context of the COVID-19 pandemic and to explore the mediating role of loneliness on the relationship between grief and mental health alterations by surveying a representative sample of 2000 Spanish adults interviewed by phone during the pandemic (February-March 2021). Logistic regressions were performed to examine the effects of grief levels on depression, anxiety, panic attacks, post-traumatic stress disorder, substance abuse, and suicidal thoughts and behaviors. Our results confirmed that how the loss of a loved one is processed is associated with the development of mental health conditions. Dysfunctional grief was significantly associated with all mental health conditions, particularly depression (OR = 14.28) and anxiety (OR = 11.61). As predicted, loneliness accounted for a substantial percentage (8-30%) of the impact of grief on mental health outcomes.
Validación Mexicana de la Escala de Integración de Experiencias de Vida Estresantes, Versión Corta
Authors: Quiroga-Garza Angélica , Ambríz-Román Bárbara , Pozas-Treviño Diana , González-Villarreal Bárbara , Torres-Treviño Vanessa , Flores-Hinojosa Daniela Sofía , Gómez-Garza Andrea
Published: May 2023

Adaptarse dando sentido a las situaciones adversas de la vida como las pérdidas inevitables a lo largo de la vida y otros eventos estresantes es crucial para que las personas mantengan su bienestar físico y psíquico. Holland et al. (2010, 2014) crearon y validaron dos versiones -larga y corta- de una escala para evaluar el grado de adaptación de un individuo ante una pérdida o un evento estresante. Con el objetivo de adaptar y validar al español mexicano Integration of Stressful Life Experiences Scale–Short Form (ISLES-SF) se llevó a cabo un estudio instrumental. En el análisis factorial exploratorio la muestra fue de 227 participantes (M=19.51, DT=1.67) y en el análisis factorial confirmatorio participaron 550 (M=19.86, DT=3.38). Ambos análisis factoriales corroboraron la estructura bifactorial, con un buen ajuste del modelo, una satisfactoria fiabilidad interna y una buena validez de constructo e instrumental, similar a las validaciones de la escala original.
Viabilidad y utilidad clínica del Protocolo Unificado Transdiagnóstico con alumnos del Aula Universitaria de Mayores de la Universidad de Cádiz
Authors: Arrigoni Flavia , Marchena Consejero Esperanza , Navarro Guzmán José I.
Published: May 2023

Los trastornos emocionales son el resultado de una triple vulnerabilidad. El contexto de pandemia incrementó la aparición de desajustes emocionales, y, ser adulto mayor en ese contexto, constituye una vulnerabilidad psicológica que puede haber favorecido la aparición de desórdenes emocionales, afectando la salud y bienestar de estas personas. Objetivo. Explorar la viabilidad y utilidad clínica del Protocolo Unificado grupal en línea para mejorar la regulación emocional en un contexto académico. Investigación con un enfoque cuantitativo, exploratorio, descriptivo e interactivo, con un diseño cuasi-experimental, pre–post test para muestras pareadas. Estudio con una muestra no probabilística de voluntarios que quedó conformada por 13 estudiantes con una edad promedio de 61,92 años de edad (DT = 4,4; rango de 55 a 70) del Aula Universitaria de Mayores de la Universidad de Cádiz que recibieron una intervención psicológica grupal, en línea, sincrónica de tres meses de duración (desde diciembre de 2020 a febrero de 2021). Se realizaron mediciones pre y post intervención. La intervención constó de 12 sesiones semanales de 90 minutos de duración. Instrumentos: OASIS, ODSIS, QLI-Sp, COP, PANAS, RRS, CORE-OM, BEAQ, NEO FFI, ficha sociodemográfica ad hoc, Escala de Satisfacción y Encuesta de valoración del tratamiento. Los resultados del Multivariate Analysis of Variance (MANOVA) muestran una reducción estadísticamente significativa (p<0.05) del malestar psicológico: CORE OM Problema (t = 2.345; p <0.037), CORE OM Funcionamiento (Z = -1.968; p < 0.049), CORE OM VISI (Z = -2.028; p <0.043) y CORE OM VISI-R (Z = -2.040; p <0.041). Tras la intervención se observó un incremento cuantitativo en la calidad de vida, el optimismo y el afecto positivo; y una reducción en la ansiedad, el afecto negativo, la conducta rumiativa, la conducta evitativa y el malestar psicológico. Para conocer el tamaño del efecto se utilizó la d de Cohen, este fue pequeño en las diferentes variables en estudio. Se hallaron altos niveles de satisfacción con el tratamiento y la mayoría manifestó estar satisfecho/a o muy satisfecho/a con la calidad del mismo. Los resultados preliminares obtenidos justifican la conveniencia de diseñar un ensayo clínico controlado aleatorizado para mostrar la eficacia clínica del Protocolo Unificado en este contexto y población. Se estima que este tipo de intervención permitiría atender las necesidades específicas de esta población y ofrecerles un espacio de cuidado de su salud y de promoción del bienestar desde el ámbito académico.
Aplicación del Protocolo Unificado para el tratamiento transdiagnóstico de los trastornos emocionales en cuidadores familiares de enfermos con demencia.
Authors: León-Casas Irene , Rodríguez-Mora Álvaro
Published: May 2023

El cuidado informal de personas con demencia se configura como una fuente de estrés crónico para las personas cuidadoras. El Modelo Multidimensional de Agentes Estresantes de Pearlin sostiene que, además de sobrecarga, los cuidadores experimentan una sintomatología clínica variada y de carácter transversal derivada de la labor de cuidado, destacando la depresión y la ansiedad como trastornos emocionales frecuentes. Aunque existen algunas intervenciones que muestran buenos resultados en el tratamiento de problemas clínicos concretos, resultan insuficientes para abordar simultáneamente la gran variedad clínica que acontece a los cuidadores. Así, se estima necesario explorar tratamientos eficaces para intervenir sobre la base transversal de la afectación emocional de este colectivo. Una propuesta sería el Protocolo Unificado para el tratamiento transdiagnóstico de los trastornos emocionales, diseñado por David Barlow, cuya razón de ser reside en el tratamiento de la base compartida y los procesos comunes de los trastornos emocionales
Race in health research: Considerations for researchers and research ethics committees
Authors: Van Staden W , Nienaber A , Rossouw T , Turner A , Filmalter C , Mercier A E , Nel J G , Bapela B , Beetge M M , Blumenthal R , Castelyn C D V , De Witt T W , Dlagnekova A G , Kotze C , Mangwane J S , Napoles L , Sommers R , Sykes L , Van Zyl W B , Venter M , Uys A , Warren N
Published: May 2023

This article provides ethical guidance on using race in health research as a variable or in defining the study population. To this end, a plain, non-exhaustive checklist is provided for researchers and research ethics committees, preceded by a brief introduction on the need for justification when using race as a variable or in defining a study population, the problem of exoticism, that distinctions pertain between race, ethnicity and ancestry, the problematic naming of races, and that race does not serve well as a presumed biological construct in genetic research.
Enterprise Evolution: A Discussion from Different Perspectives. Editorial Introduction to Issue 34 of CSIMQ
Authors:   University of Rostock, Computer Science Department, Chair in Software Engineering,  Albert-Einstein-Str. 22, 18059 Rostock, Germany, Forbrig Peter
Published: May 2023

The current issue provides discussions on different topics that can be summarized as “Enterprise Evolution”. The selected articles continue and elaborate research that was presented in 2022 during workshops at the Perspectives in Business Informatics Research Conference – BIR 2022 in Rostock, Germany. The articles continue the research work presented at the conference, summarize the findings and provide deeper insights and new perspectives. The articles report on research results regarding ethical, social, and environmental accounting; support for post-merger information systems integration; enterprise architecture for inclusion of demand-responsive services in the overall enterprise architecture of transportation companies; and possibilities of SMEs to use robotic solutions for enhancing their processes.
Supporting Information System Integration Decisions in the Post-Merger Context
Authors:   Department of Artificial Intelligence and Systems Engineering, Faculty of Computer Science and Information Technology, Riga Technical University, 6A Kipsalas Street, Riga, LV-1048, Latvia, Lace Ksenija
Published: May 2023

Consolidation of organizations and assets through Mergers and Acquisitions (M&A) is one of the strategies for organizational growth. However, despite the big popularity, the results of M&A initiatives are questionable. The main idea behind M&A is to create a new organization by combining several existing organizations. This new organization is created through a transformation process often called a post-merger. A significant part of the post-merger process is the integration of information systems. The success of post-merger information systems integration is the result of successful integration decisions. This study focuses on the problem of how a novice organization in post-merger initiatives can handle complexity in the decision-making process of post-merger information systems integration with its internal resources, without involvement of an external expertise, but with a support method to compensate the lack of expertise for informed decision-making. The extended decision-making process can be divided into three phases – identification of necessary decisions, decision-making, and decision implementation. This study focuses on the first two phases. For each of the phases, a specialized sub-method was developed, focused, respectively, on the identification of necessary decisions (AMILI) and decision-making as a choice between possible integration options (AMILP). Supporting tools were also developed for each of the sub-methods.
Enterprise Architecture for Integration of Demand-Responsive Services in Public Transport
Authors:   University of Rostock, Albert-Einstein-Str. 22, 18059 Rostock, Germany, Würtz Mark-Oliver ,   Jellyco GmbH, Am Fuchsberg 45, 28816 Stuhr, Germany, Sandkuhl Kurt ,   University of Rostock, Albert-Einstein-Str. 22, 18059 Rostock, Germany,   Jönköping University, Box 1026, 55111 Jönköping, Sweden
Published: May 2023

The popularity of new mobility services (NMS), like car sharing, urban bikes or e-scooters, is increasing in many urban areas. In comparison to traditional supply-oriented public transport with defined timetables and transportation routes, NMS are demand-responsive services aiming to meet the ad-hoc needs of users. NMS have started to influence the way people move in urban areas, and they also have an impact on public transport operators which begin to offer their own NMS or integrate the services of established NMS operators. This article investigates the changes implied by NMS for the enterprise architecture (EA) of public transport operators. The paper presents and evaluates an EA approach for integrating demand-responsive services into traditional supply-oriented public transport. We propose a partial enterprise architecture as an extension of the established ITVU core model, which is an established reference model in the public transportation domain. Although EA management is recognised as relevant for public transport companies, there is a lack of such an extension addressing NMS integration. The contribution of this article are to (1) offer an overview of the state of research in enterprise architectures for public transport, (2) make a case study for illustrating the challenges and requirements of NMS integration, (3) provide a first version of the partial (core) reference EA for integration of NMS including an initial evaluation.
Rapid and precise genome engineering in a naturally short-lived vertebrate
Authors: Bedbrook Claire N , Nath Ravi D , Nagvekar Rahul , Deisseroth Karl , Brunet Anne
Published: May 2023

The African turquoise killifish is a powerful vertebrate system to study complex phenotypes at scale, including aging and age-related disease. Here, we develop a rapid and precise CRISPR/Cas9-mediated knock-in approach in the killifish. We show its efficient application to precisely insert fluorescent reporters of different sizes at various genomic loci in order to drive cell-type- and tissue-specific expression. This knock-in method should allow the establishment of humanized disease models and the development of cell-type-specific molecular probes for studying complex vertebrate biology.
Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility
Authors: Gomez Sofia , Bureau Lionel , John Karin , Chêne Elise-Noëlle , Débarre Delphine , Lecuyer Sigolene
Published: May 2023

Surface-associated lifestyles dominate in the bacterial world. Large multicellular assemblies, called biofilms, are essential to the survival of bacteria in harsh environments and are closely linked to antibiotic resistance in pathogenic strains. Biofilms stem from the surface colonization of a wide variety of substrates encountered by bacteria, from living tissues to inert materials. Here, we demonstrate experimentally that the promiscuous opportunistic pathogen Pseudomonas aeruginosa explores substrates differently based on their rigidity, leading to striking variations in biofilm structure, exopolysaccharides (EPS) distribution, strain mixing during co-colonization and phenotypic expression. Using simple kinetic models, we show that these phenotypes arise through a mechanical interaction between the elasticity of the substrate and the type IV pilus (T4P) machinery, that mediates the surface-based motility called twitching. Together, our findings reveal a new role for substrate softness in the spatial organization of bacteria in complex microenvironments, with far-reaching consequences on efficient biofilm formation.
ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells
Authors: Sadhu Lopamudra , Tsopoulidis Nikolaos , Hasanuzzaman Md , Laketa Vibor , Way Michael , Fackler Oliver T
Published: May 2023

CD4 T cell activation induces nuclear and cytoplasmic actin polymerization via the Arp2/3 complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling. Actin polymerization dynamics and filament morphology differ between nucleus and cytoplasm. However, it is unclear how the Arp2/3 complex mediates distinct nuclear and cytoplasmic actin polymerization in response to a common stimulus. In humans, the ARP3, ARPC1, and ARPC5 subunits of the Arp2/3 complex exist as two different isoforms, resulting in complexes with different properties. Here, we show that the Arp2/3 subunit isoforms ARPC5 and ARPC5L play a central role in coordinating distinct actin polymerization events in CD4 T cells. While ARPC5L is heterogeneously expressed in individual CD4 T cells, it specifically drives nuclear actin polymerization upon T cell activation. In contrast, ARPC5 is evenly expressed in CD4 T cell populations and is required for cytoplasmic actin dynamics. Interestingly, nuclear actin polymerization triggered by a different stimulus, DNA replication stress, specifically requires ARPC5 but not ARPC5L. TCR signaling but not DNA replication stress induces nuclear actin polymerization via nuclear calcium-calmodulin signaling and N-WASP. Diversity in the molecular properties and individual expression patterns of ARPC5 subunit isoforms thus tailors Arp2/3-mediated actin polymerization to different physiological stimuli.
Mouse B2 SINE elements function as IFN-inducible enhancers
Authors: Horton Isabella , Kelly Conor J , Dziulko Adam , Simpson David M , Chuong Edward B
Published: May 2023

Regulatory networks underlying innate immunity continually face selective pressures to adapt to new and evolving pathogens. Transposable elements (TEs) can affect immune gene expression as a source of inducible regulatory elements, but the significance of these elements in facilitating evolutionary diversification of innate immunity remains largely unexplored. Here, we investigated the mouse epigenomic response to type II interferon (IFN) signaling and discovered that elements from a subfamily of B2 SINE (B2_Mm2) contain STAT1 binding sites and function as IFN-inducible enhancers. CRISPR deletion experiments in mouse cells demonstrated that a B2_Mm2 element has been co-opted as an enhancer driving IFN-inducible expression of Dicer1. The rodent-specific B2 SINE family is highly abundant in the mouse genome and elements have been previously characterized to exhibit promoter, insulator, and non-coding RNA activity. Our work establishes a new role for B2 elements as inducible enhancer elements that influence mouse immunity, and exemplifies how lineage-specific TEs can facilitate evolutionary turnover and divergence of innate immune regulatory networks.
Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes
Authors: Zhuang Aojia , Zhuang Aobo , Chen Yijiao , Qin Zhaoyu , Zhu Dexiang , Ren Li , Wei Ye , Zhou Pengyang , Yue Xuetong , He Fuchu , Xu Jianmin , Ding Chen
Published: May 2023

The presence of lymph node metastasis (LNM) affects treatment strategy decisions in T1NxM0 colorectal cancer (CRC), but the currently used clinicopathological-based risk stratification cannot predict LNM accurately. In this study, we detected proteins in formalin-fixed paraffin-embedded (FFPE) tumor samples from 143 LNM-negative and 78 LNM-positive patients with T1 CRC and revealed changes in molecular and biological pathways by label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) and established classifiers for predicting LNM in T1 CRC. An effective 55-proteins prediction model was built by machine learning and validated in a training cohort (N=132) and two validation cohorts (VC1, N=42; VC2, N=47), achieved an impressive AUC of 1.00 in the training cohort, 0.96 in VC1 and 0.93 in VC2, respectively. We further built a simplified classifier with nine proteins, and achieved an AUC of 0.824. The simplified classifier was performed excellently in two external validation cohorts. The expression patterns of 13 proteins were confirmed by immunohistochemistry, and the IHC score of five proteins was used to build an IHC predict model with an AUC of 0.825. RHOT2 silence significantly enhanced migration and invasion of colon cancer cells. Our study explored the mechanism of metastasis in T1 CRC and can be used to facilitate the individualized prediction of LNM in patients with T1 CRC, which may provide a guidance for clinical practice in T1 CRC.
Larger but younger fish when growth outpaces mortality in heated ecosystem
Authors: Lindmark Max , Karlsson Malin , Gårdmark Anna
Published: May 2023

Ectotherms are predicted to ‘shrink’ with global warming, in line with general growth models and the temperature-size rule (TSR), both predicting smaller adult sizes with warming. However, they also predict faster juvenile growth rates and thus larger size-at-age of young organisms. Hence, the result of warming on the size-structure of a population depends on the interplay between how mortality rate, juvenile- and adult growth rates are affected by warming. Here, we use two-decade long time series of biological samples from a unique enclosed bay heated by cooling water from a nearby nuclear power plant to become 5–10 °C warmer than its reference area. We used growth-increment biochronologies (12,658 reconstructed length-at-age estimates from 2426 individuals) to quantify how >20 years of warming has affected body growth, size-at-age, and catch to quantify mortality rates and population size- and age structure of Eurasian perch (Perca fluviatilis). In the heated area, growth rates were faster for all sizes, and hence size-at-age was larger for all ages, compared to the reference area. While mortality rates were also higher (lowering mean age by 0.4 years), the faster growth rates lead to a 2 cm larger mean size in the heated area. Differences in the size-spectrum exponent (describing how the abundance declines with size) were less clear statistically. Our analyses reveal that mortality, in addition to plastic growth and size-responses, is a key factor determining the size structure of populations exposed to warming. Understanding the mechanisms by which warming affects the size- and the age structure of populations is critical for predicting the impacts of climate change on ecological functions, interactions, and dynamics.
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury
Authors: Huang Long Shuang , Anas Mohammad , Xu Jingsong , Zhou Bisheng , Toth Peter T , Krishnan Yamuna , Di Anke , Malik Asrar B
Published: May 2023

Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues. Here, we report that during homeostasis, TWIK2 resides in endosomal compartments. TWIK2 is transported by endosomal fusion to the plasmalemma in response to increased extracellular ATP resulting in the extrusion of K+. We showed that ATP-induced endosomal TWIK2 plasmalemma translocation is regulated by Rab11a. Deleting Rab11a or ATP-ligated purinergic receptor P2X7 each prevented endosomal fusion with the plasmalemma and K+ efflux as well as NLRP3 inflammasome activation in macrophages. Adoptive transfer of Rab11a-depleted macrophages into mouse lungs prevented NLRP3 inflammasome activation and inflammatory lung injury. We conclude that Rab11a-mediated endosomal trafficking in macrophages thus regulates TWIK2 localization and activity at the cell surface and the downstream activation of the NLRP3 inflammasome. Results show that endosomal trafficking of TWIK2 to the plasmalemma is a potential therapeutic target in acute or chronic inflammatory states.
Tradeoffs explain scaling, sex differences, and seasonal oscillations in the remarkable weapons of snapping shrimp (Alpheus spp.)
Authors: Dinh Jason P , Patek SN
Published: May 2023

Evolutionary theory suggests that individuals should express costly traits at a magnitude that optimizes the trait bearer’s cost-benefit difference. Trait expression varies across a species because costs and benefits vary among individuals. For example, if large individuals pay lower costs than small individuals, then larger individuals should reach optimal cost-benefit differences at greater trait magnitudes. Using the cavitation-shooting weapons found in the big claws of male and female snapping shrimp, we test whether size- and sex-dependent expenditures explain scaling and sex differences in weapon size. We found that males and females from three snapping shrimp species (Alpheus heterochaelis, Alpheus angulosus, and Alpheus estuariensis) show patterns consistent with tradeoffs between weapon and abdomen size. For male A. heterochaelis, the species for which we had the greatest statistical power, smaller individuals showed steeper tradeoffs. Our extensive dataset in A. heterochaelis also included data about pairing, breeding season, and egg clutch size. Therefore, we could test for reproductive tradeoffs and benefits in this species. Female A. heterochaelis exhibited tradeoffs between weapon size and egg count, average egg volume, and total egg mass volume. For average egg volume, smaller females exhibited steeper tradeoffs. Furthermore, in males but not females, large weapons were positively correlated with the probability of being paired and the relative size of their pair mates. In conclusion, we identified size-dependent tradeoffs that could underlie reliable scaling of costly traits. Furthermore, weapons are especially beneficial to males and burdensome to females, which could explain why males have larger weapons than females.