bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumour - Related Epilepsy and Post-Surgical Outcome: Tertiary Hospital Experience in Saudi Arabia
Authors: Alattas Alawi Aqel Aqel Abdullah , Al-Hindi Hindi , AbaAlkhail Tariq , Bawazir Amen , Aldhalaan Hesham , Althubaiti Ibrahim , Baz Salah
Published: August 2020

Background Some studies have suggested that tumor pathology significantly influence freedom from seizures post epilepsy surgery; however, there is no consensus among researchers regarding this issue. This study aims to retrospectively look for different types of tumor- related epilepsy and their outcomes in the first-year post epilepsy surgery among both adults and children. Methods In this hospital-based retrospective study, patients with drug resistant epilepsy due to brain tumor who underwent epilepsy surgery were included. Our patients underwent a thorough presurgical evaluation in an Epilepsy Monitoring Unit (EMU) before deciding to undergo surgical intervention, according to an epilepsy case-management conference. Four outcomes of interest were investigated during the first-year post epilepsy surgery.Results One hundred patients with brain tumors were included in this study (male: female = 3:2); 45 patients were children. Most of the patients (93) had low-grade gliomas or glioneuronal tumors (G/GNT). No significant differences in outcome were observed between sex, age, or histopathological categories. However, during the first year after epilepsy surgery most of the low-grade G/GNT cases showed favorable outcomes of International League Against Epilepsy (ILAE) class 1 and 2 (61.3% and 9.7%, respectively), while high-grade gliomas and meningothelial tumors showed outcomes of ILAE class 1 (40% and 100%, respectively). Conclusions One-year favorable outcome of post epilepsy surgery of different brain tumors have been achieved among both children and adults. Adequate presurgical evaluation in EMU (for long-term video-electroencephalography monitoring) to plan appropriate surgical strategy is advised. Tumor Pathology does not influence seizure outcome one-year post epilepsy surgery.
Trogloregions: delimiting subterranean faunistic identities in Afrotropics and Neotropics
Authors: Alvarenga Denizar , Silva Marconi , Ferreira Rodrigo
Published: August 2020

Studies regarding macroecological patterns involving subterranean fauna are challenging, since the environments where such species are found generally do not have the same ecological patterns observed on the surface, due to their isolation. Therefore, using data on the occurrence of invertebrate families, we tested the influence of ecological regions already established for surface environments (biogeographic domains, biomes, and ecoregions), lithology, and drainage basins as potential drivers of the similarity on the invertebrates communities. We observed that within the surface ecoregions there might still be subdivisions due to different drainage basins, a pattern that was repeated in both aquatic and terrestrial fauna. Thus, we present different bioregions in the Afrotropics and Neotropics, in which caves have distinct faunistic identities. We discuss the biogeographic relationships between the epigean and hypogean environments that may be behind these patterns. We believe that these results can assist in conservation strategies, in which these different compositions are considered.
N-CAM expression: The study of muscle disease in a tertiary center of Thailand
Authors: Laoyoung Kanyarat , Waisayarat Phu , Dejthevaporn Charungthai , Khongkhatithum Chaiyos , Waisayarat Jariya
Published: August 2020

Objectives To evaluate the correlation between N-CAM expression and diagnosis of common muscle diseases in the Thai population.Methods The expression of N-CAM was interpreted in 75 muscle biopsy specimens diagnosed with myopathies in a 3-year retrospective study. We used anti-CD56 (MRQ-42) rabbit monoclonal primary antibody (1:200, Cell Marque, MilliporeSigma, Rocklin, CA, USA) in our immunohistochemical study.Results Of our 75 patients, 41 cases were female and 34 were male. The mean age of the patients was 35-year-old, with the range from 3 months to 83 years. 35 (46.67%) of the specimens were N-CAM-positive, and 40 (53.33%) were N-CAM-negative. There were 35 (46.67%) cases diagnosed with nonspecific myopathy, 17 (22.67%) with inflammatory myopathy, 9 (12.00%) with neurogenic dystrophy, 7 (9.33%) with muscular dystrophy, 5 (6.67%) with non-diagnostic myopathy, and 2 (2.67%) with mitochondrial myopathy. Chi-squared testing was used to analyze the N-CAM expression data and the diagnosis. There is a statistically significant correlation between inflammatory myopathy and N-CAM positivity (p-value <0.001, OR 14.250, 95% CI 2.960-68.606), with 15 out of 17 cases being N-CAM-positive. N-CAM was also positive in muscular dystrophy, neurogenic myopathy, and nonspecific myopathy but they were not statistically significant. We did not find N-CAM expression in our 2 mitochondrial myopathy cases, nor in the 5 non-diagnostic myopathy cases.Conclusion N-CAM expression can be a complementary tool for diagnostic evaluation in muscle diseases with regeneration or denervation of muscle fibers. We recommend further study in a larger group.
Development of HPLC Based QuEChERS Method for High Recovery of Fungicides From Vegetable Samples
Authors: Majid Abdul , Ali Zeeshan , Husssain Dilshad , Sajid Muhammad
Published: August 2020

Vegetables are the most essential part of our diet. Several pesticides are used to kill the pests. These pest cause different diseases on vegetable plants. As a result of which they are getting more and more production of vegetables but there are many hazards for humans. To get rid of this problem, a simple QuEChERS method is used which is based on solvent extraction method in which different salts and acetonitrile were used. In this method clean-up process and extraction were important HPLC technique is used to determine the accurate results. Despicable recoveries of fungicides were ranges between 0.63% to 107.68% at spiking levels and at different factors through percentage RSD between 3.6% to 4.7%. LOD of two fungicides were in the range of 0.0021mg/kg to 0.00181mg/kg and LOQ of two fungicides were in the range of 0.0706mg/kg to 0.00606mg/kg. By varying many factors the recoveries of fungicides may vary. The recoveries of two fungicides may increase by increasing temperature, pH and concentration but decrease with the passage of time due to degradation of fungicides. By this QuEChERS method we get different concentration of fungicides in some vegetables but in Methi vegetables they are absent. And determinations and extraction of fungicides were completed by HPLC technique. QuEChERS method is very efficient and good method for determination of pesticides in various vegetables. Hence our experimental results were validated with this efficient method.
ADAM10 Plasma Levels Predict Worsening in Cognition of Older Adults: A 3-Year Follow-Up Study
Authors: Monteiro Maria Patricia A Oliveira , Oliveira Danielle S. M. Salheb , Manzine Patricia Regina , Nascimento Carla Manuela Crispim , Orlandi Ariene A. dos Santos , Gomes Grace A. de Oliveira , Orlandi Fabiana dos Santos , Zazzetta Marisa Silvana , Pott Henrique , Cominetti Marcia Regina
Published: August 2020

Background

Blood-based biomarkers for Alzheimer’s disease (AD) are highly needed in clinic practice. So far, the gold standards for AD diagnosis are brain neuroimaging and beta-amyloid peptide, total tau and phosphorylated tau in cerebrospinal fluid (CSF), however, they are not attractive for large-scale screening. Blood-based biomarkers will allow an initial large-scale screening of patients under suspicion that could later be tested for the already established CSF biomarkers. To this regard, we and other research groups have already described that the plasma and platelet levels of ADAM10 are higher or lower, respectively, in patients with AD, compared to those cognitively healthy.
Methods

This was a three-year longitudinal cohort study that included 219 community-dwelling older adults. Sociodemographic, clinical, lifestyle, depressive symptoms (GDS) and cognitive data (Mini-Mental State Examination, MMSE; Clock Drawing test, CDT) were gathered. The measurement of ADAM10 plasma levels was performed using a sandwich ELISA kit. Bivariate comparisons between groups were performed using Wilcoxon-Mann-Whitney for continuous data and Pearson’s chi-square tests with Yates continuity correction, for categorical data. Longitudinal analyzes of changes in the MMSE score were performed using Linear Mixed-Effects modeling.
Results

Baseline MMSE score and ADAM10 values were significantly associated with MMSE score values on the follow-up assessment. When analyzing the interaction with time, having a normal MMSE at baseline and ADAM10 plasma levels presented a significant and independent negative association with MMSE score values on the follow-up assessment. The analyses also showed that the effect of ADAM10 plasma levels on decreasing MMSE score values on follow-up seems to be more pronounced in those with normal MMSE at baseline. Taken together, these results provide the first direct evidence that changes in ADAM10 plasma levels are predictors of cognitive worsening in older adults.
Conclusions

Considering that ADAM10 increase in plasma is detected as soon as in mild cognitive impairment (MCI) patients, the results presented here may support the complementary clinical use of this biomarker, in addition to the classical AD biomarkers. Moreover, this work can shed light on the study of blood biomarkers for AD and contribute to the advancement of the area.
The Role of CENPO Expression in the Progression of Non-Small Cell Lung Cancer
Authors: Yang Yanlong , Chen Xiaobo , Sun Hongwen , Yu Qinghe , Yin Fang , Hu Zaoxiu , Sun Yongmeng , Pu Lisha , Zhu Xinming , Li Shen , Zhao Yunping
Published: August 2020

Background: The role of Centromere protein O (CENPO) in the development of non-small cell lung cancer (NSCLC) is unknown. This study aimed to investigate the potential roleof CENPO in the development of NSCLCMethods: The expression level of CENPO was investigated in both tissues and cell-lines. Celigo cell counting assay, wound-healing assay, Transwell assay and Flow cytometry was used to explore the effect of CENPO on proliferation, migration, invasion, apoptosis and cell cycle of NSCLC. The potential mechanism of CENPO was explored by Human Apoptosis Antibody, also, western blot was conducted to detect the expression of PI3K/Akt/mTOR pathway and cell-cycle related protein (mTOR, P-mTOR, CDK1, CDK6 and PIK3CA). Besides, the effect of CENPO on the growth of NSCLC solid tumors was demonstrated in vivo.Results: Our study suggested CENPO gene overexpression in NSCLC. Reduced CENPO expression substantially decreased the proliferation, migration and invasion ability, and promoting apoptosis and induces cell cycle arrest of NSCLC cell-lines. Preliminary mechanism research suggested reduced CENPO could active apoptosis pathway, suppressing PI3K/AKT/mTOR pathway and down-regulation cell-cycle related proteins.Conclusion: CENPO was up-regulated in NSCLC and played an important role in promoting the progress of NSCLC.
Analysis of Correlation Between Whole Exome Sequencing and Ultrasound Examinationin Prenatal Diagnosis of Fetal Skeletal Dysplasia 
Authors: Tian Yuan , Yuan Erfeng , Gao Jinshuang , Guo Yaqing , Yu Haiyang , Zhang Linlin , Zhang Xiao’an , Zhao Xin , Yuan Enwu , Cui Shihong
Published: August 2020

Background:Fetal skeletal dysplasia is a disease that is difficult to distinguish these types of diseases during the fetal period. Due to the difficulty of fetal ultrasound diagnosis, the severity of fetal skeletal dysplasia is extremely difficult to assess.Methods: 79 fetal samples of skeletal dysplasia from the third affiliated hospital of Zhengzhou University, China from August 2018 to April 2020, which had undergone prenatal whole exome sequencing(WES) were analyzed and the results of whole-exome sequencing and fetal ultrasound test results were compared. Results:We find that the fetal short limb phenotype found in the range of FL<-4.0SD or HL<-4.0SD through ultrasound test is closely related to FGFR3 gene mutation , and the correlation is stronger when accompanied by macrocephaly. We also find that the fetal limb curved phenotype is closely related to COL1A1 gene mutation. At the same time, we find that nasal dysplasia during fetal period is also a common phenotype of abnormal results detected by whole exome sequencing.Conclusions: Our research shows that WES has different detection rates for various skeletal abnormalities according to the different types of ultrasound detection results, which provides a meaningful guidance for clinical diagnosis of fetal skeletal dysplasia.
Relationship of Red Cell Index with the Severity of COPD
Authors: Huang Yiben , Wang Jianing , Shen Jiamin , Ding Keke , Huang Honghao , Yang Chenguang , Fu Fangyi , Hu Binbin , Pan Wenjing , Jia Jiaying , Tong Wangyong , Zhou Xinbo , Zhang Xiaodiao
Published: August 2020

Background: Chronic obstructive pulmonary disease (COPD) has always attracted attention due to its high prevalence and high mortality. How to predict and diagnose COPD and assess the severity of the disease is our top priority. We aimed to evaluate the association between red cell index (RCI) and the severity of COPD, and compare predictive value among RCI, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) of indicating the severity of COPD.Methods: A total of 207 participants were recruited (100 COPD patients and 107 healthy controls). COPD patients were divided into two groups according to receiver operating characteristics (ROC) curves cut-off value of RCI (RCI < 1.75, n = 54; RCI > 1.75, n = 46). Pearson’s correlation test, logistic regression analysis and other tests were performed.Results: Compared with low RCI group, the forced expiration volume in 1 second (FEV1) and FEV1 in percent of the predicted value (FEV1%) of high RCI group decreased (p = 0.016, p = 0.001). There is a negative correlation between RCI and FEV1% (r = -0.302, p = 0.004), while no correlation between FEV1% and NLR and PLR. RCI’s ability to predict Global Initiative for Chronic Obstructive Lung Disease classification, is better than NLR and PLR, with a cut of 1.75, specificity of 85.2%, sensitivity of 57.6% and area under the curve (AUC) of 0.729 (p = 0.001). Multivariate logistic regression analysis proved RCI was an independent factor affecting lung function in COPD patients (odds ratio [OR] = 4.27, 95%CI: 1.57 - 11.63, p = 0.004). Conclusion: RCI is a novel biomarker that can better assess respiratory function and severity of COPD than NLR and PLR. Higher RCI is independently related to deterioration of respiratory function.
Two-layer duct-to-mucosa pancreaticojejunostomy with a half purse-string suture: A novel anastomosis technique for soft pancreas
Authors: Meng Yao , Jiang Yabo , Jing Wei , Zheng Kailian , Cheng Peng , Zhang Yijie , Jin Gang , He Tianlin
Published: August 2020

Background: Pancreaticoduodenectomy (PD) is a routine method in pancreatic surgery. To date, postoperative pancreatic fistula (POPF) remains the most common complication and is also the major cause to death after pancreaticoduodenectomy. In order to reduce the incidence of POPF, we established a new anastomosis technique where we use a half purse-string suture on the basis of two-layer duct-to-mucosa pancreaticojejunostomy (PJ) technique and also assessed the effectiveness and safety of this approach in this study.Methods: To evaluate this new approach, 80 patients who received the new PJ technique were included in this study during 2017–2018. Meanwhile, 195 patients who underwent traditional duct-to-mucosa PJ were collected. We also introduced this new surgical approach in detail and analyzed various risk factors for postoperative complications to verify its safety and advantages.Results: First of all, there were no significant differences in patients' preoperative characteristics. Besides, patients in the new PJ group received a less operative time (175.2±45.8 vs. 161.3±41.0, p=0.022) while no differences were found in blood loss, length of hospital stay and cost. The incidence of POPF in the new PJ group was 19%, which was much lower than those in the traditional PJ group (36%) (p=0.007). More importantly, a much lower incidence of grades B POPF (14% vs. 4%, p=0.026) was found in the new technology group, which would clinically benefit patients a lot. Univariate and multivariate regression analysis also verified that this new PJ procedure was effective to improve postoperative POPF.Conclusions: Results demonstrate that this new technique is easy accomplished, safe and effective compared to traditional approach, which showed satisfactory outcomes especially at resulting in a lower POPF incidence.
Comparison of Short-Term Efficacy of Total Knee Arthroplasty Versus Arthroscopy in Chinese Patients with Knee Osteoarthritis
Authors: Jia Xiaolin , Cai San , Hu Wei , Gan Qiang , Zhou Mingquan
Published: August 2020

Background: The purpose of this study was to compare the improvement of knee function in patients with knee osteoarthritis who underwent total knee arthroplasty and arthroscopy in China, and to provide a scientific basis for the application of clinical total knee arthroplasty in knee osteoarthritis.Methods: A total of 160 patients with knee osteoarthritis who were admitted to Chinese hospital from January 2017 to December 2018 were studied. They were divided into experimental group and control group according to their willingness of treatment. The control group was treated with arthroscopy and the experimental group was treated with total knee arthroplasty. All patients were followed for a period of 6 months. The knee joint function score (HSS), visual analog scale (VAS), and anxiety self-assessment scale (SAS) scores before and after surgery were compared between the two groups. Results: The proportion of "excellent or good" in the efficacy of the experimental group (91.25%) was higher than that of the control group (72.50%), and the difference was statistically significant (χ2=9.476, P<0.05). The HSS score of the experimental group was higher than that of the control group (P<0.05), while the VAS and SAS scores were lower than those of the control group (P<0.05). The scores of various SF-36 scales in the experimental group were higher than those in the control group after operation (P<0.05).Conclusions: Total knee arthroplasty was considered effective in treating patients with knee osteoarthritis that meet the indications, and is beneficial to improve knee function and reduce pain in patients. The surgical treatment also reduced the level of anxiety and effectively improve the quality of life of patients. Further investigation of its clinical application on treatment of knee osteoarthritis is warranted.
Sputum Microbiota in Coal Workers Diagnosed With Pneumoconiosis as Revealed by 16S Metagenomic Sequencing
Authors: Druzhinin Vladimir , Matskova Liudmila , Demenkov Pavel , Baranova Elizaveta , Volobaev Valentin , Minina Varvara , Larionov Alexey , Paradnikova Snezhana
Published: August 2020

Objectives: The microbiome of sputum from former and active coal miners diagnosed with coal worker’s pneumoconiosis (CWP) as compared to healthy controls Methods: Next Generation Sequencing of bacterial 16S rRNA genes obtained from the sputum of CWP subjects.Results: Differences were detected between the sputum microbiomes from the healthy and CWP subjects. We noted a significant decrease in Bacteroidetes and an increase in the level of Proteobacteria.Conclusions: The microbiomes found in sputum from CWP subjects are enriched in bacterial species previously reported to induce pro-inflammatory responses. The profile of the microbiomes correlated mainly to the occupational activity and not to the age of the coal miners.
The Changes of Serum Lipids in Idiopathic Epiretinal Macular Membranes
Authors: Feng Liguo , Chen Ying , Xu Yesheng , Xie Wenjia , Sun Yi , Wang Binghong , Yao Yu-Feng
Published: August 2020

Purpose: To describe the changes of serum lipids in patients with idiopathic epiretinal macular membranes (iERMs). Methods: A retrospective, observational case control study was performed January 2015 and December 2019 in our unit. A total of 57 subjects with idiopathic epiretinal macular membranes were collected in the study. Senile cataract patients with age matched during hospitalizations were randomly collected as control group. iERMs were diagnosed based on OCT images. Comprehensive ophthalmologic examinations and Systemic examinations were performed. The changes of serum lipids were analyzed. Results: The iERMs was common in female (71.9%). Compared to control group, Serum triglycerides were higher in iERMs group (1.54 ± 0.66 vs 1.21 ± 0.50, P < 0.01). There was significant difference in BMI with iERM (23.68 ± 2.86 vs 22.50 ± 2.71, P = 0.03). After subjects stratified according whether with hypertension diseases, there was still statistical difference in serum triglycerides (P < 0.05). Conclusions: Serum triglycerides and BMI are elevated in patients with iERMs. It suggests that obese people seem to be prone to iERMs. Hyperlipemia seems to play a role in the formation of iERMs.
The Outbreak of COVID-19 Pandemic and Its Impact on Stock Market Volatility: Evidence from a Worst-affected Economy
Authors: Bora Debakshi , Basistha Daisy
Published: August 2020

The outbreak of COVID-19 has affected the entire global financial market in an unprecedented way. Due to the disruptions that emerged in the global market; the financial market of India also reacted to the pandemic and witnessed sharp volatility. Given the COVID-19 situation, this paper empirically investigates the impact of COVID-19 on the Indian stock market. Using daily closing prices of indices such as Nifty and Sensex, this study examines the volatility of these indices over the period 3rd September 2019 to 10th July 2020. Further, the study has attempted to make a comparative analysis of the return of the stock market in pre-COVID-19 and during the COVID-19 situation. GARCH model is used to capture the volatility of the indices. Findings reveal that the stock market in India has experienced volatility during the pandemic period. While comparing the results with that of the pre-COVID-19 period, we find that return on the indices is higher in the pre-COVID-19 period than during COVID-19. The return of both the stock market reached the bottom line during the first lockdown period, which is from24th March to 6th April.
CORO6 Promotes Cell Growth and Invasion of Clear Cell Renal Cell Carcinoma via Activation of WNT Signaling
Authors: Wang Xinjun , Xiao Yiming , Yan Zhijian , Luo Guangcheng
Published: August 2020

BackgroundRenal cell carcinoma (RCC) constitutes the most lethal type of genitourinary cancer. Understanding of RCC tumor biology helps to identify novel targets and develop directed treatments for patients with this type of cancer. MethodsBioinformatical Analysis of The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma dataset. Western blotting and qPCR were used to examine the expression levels of interested genes. Flow cytometry, MTT, BrdU staining, wound healing assay and transwell invasion assay were applied to determine the biological functions of CORO6 in ccRCC cells. The in vivo effect of CORO6 on ccRCC development was validated with xenografted mouse model.ResultsAnalysis from both The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma dataset and our RCC samples demonstrated that the expression level of CORO6 was significantly higher in RCC patients than in normal kidney tissues, and its level was highly associated with tumor stage and grade. Importantly, CORO6 expression level was an independent predictor of tumor metastasis and overall survival in RCC patients. Our cell line data also confirmed that CORO6 knockdown could suppress RCC cell growth as well as cell migration and invasion. The depletion of CORO6 led to cell cycle arrest at the G0/G1 phase and caused cell apoptosis. Further, mechanistic dissection showed that CORO6 mediated RCC cell growth, and cell invasion relied on WNT signaling. Moreover, the in vivo data suggested that CORO6 knockdown indeed suppressed RCC tumor growth. ConclusionsOverall, our study defines the oncogenic role of CORO6 in RCC progression and provides a rationale for developing CORO6-targeted therapies for improved treatment of RCC patients.
Performance of Aquaculture Effluent for Tomato Production in Outdoor Raised Beds
Authors: Pattillo D. Allen , Foshee Wheeler G. , Blythe Eugene K. , Pickens Jeremy , Wells Daniel , Monday Tyler A. , Hanson Terrill R.
Published: August 2020

Raised bed production trials were conducted to evaluate the effectiveness of effluent from a biofloc-style recirculating aquaculture system producing nile tilapia (Oreochromis niloticus) as nutrient-rich irrigation water for fall ‘Celebrity’ tomato (Solanum lycopersicum) production. The objective of this study was to provide baseline vegetable production data and justification for using aquaculture effluent as a water and nutrient resource. The experiment was a split-plot, randomized block design with three treatments: aquaculture effluent, granular fertilizer, and fertigation. Tomato seeds were sown in June, transplanted in August, and grown until Oct. 2019 in nine replicated raised beds. Conventional field tomato production practices were followed throughout the trial, and data were collected for tomato fruit yield, market quality, size, leaf greenness (SPAD), and foliar nutrient analysis. Fruit yield was similar between fertigated and aquaculture effluent treatments, with granular fertilizer resulting in yield that was significantly lower (P ≤ 0.033). SPAD measurements were similar among treatments. All nutrients met or exceeded sufficiency ranges. Foliar nutrient analysis revealed no significant difference for nitrogen, phosphorus, potassium, magnesium, calcium, boron, zinc, manganese, and iron among treatments. Sulfur and copper levels were significantly lower (P < 0.05) with aquaculture effluent treatment as compared with the granular and fertigated treatments. Overall, tomato production using aquaculture effluent as a water and nutrient supplement produced similar yields to commercial practices, making it potentially viable for producers.
Hydrobiological characteristics of the Don River in the region of the Bagayevsky hydroelectric complex construction
Authors: Zhivoglyadova L. A. , Safronova L. M. , Shlyahova N. A. , Bondarev S. V. , Naletova L. Yu. , Afanasyev D. F.
Published: August 2020

The data on the taxonomic composition and quantitative characteristics of planktonic and benthic communities of the Lower Don in the area of construction of the Bagaevsky hydroelectric complex have been presented. In June - July 2018, a comprehensive hydrobiological survey was carried out to assess the taxonomic composition and quantitative characteristics of phytoplankton, zooplankton and zoobenthos. Hydrobiological samples were taken at 21 stations using standard techniques. The phytoplankton communities contained 110 taxa, zooplankton - 58, zoobenthos - 78. The spatial distribution of quantitative indicators of plankton and benthos in the investigated area has been presented. Phytoplankton abundance varied from 2,006.0 to 6,128.0 million cells/m, biomass - from 1.00 to 7.37 g/m, the average polygon indicators were 3,636.6 ± 223.5 million cells/m and 4.28 ± 0.39 g/m respectively. In terms of the number of registered taxa and quantitative indicators, two groups of phytoplankton dominated - cyanobacteria and green algae. The abundance of zooplankton ranged from 2,580 to 238,622 ind./m, biomass ranged from 36.4 to 476.0 mg/m, the average abundance was 74,690 ± 15,017 ind./m and 172.7 ± 24.8 mg/m respectively. Rotifers and cladocerans were the leaders in the number of species. Meroplankton was dominant in numbers (mainly due to mollusk larvae), and copepods were the dominant group in biomass. The number of bottom invertebrates varied from 20 to 17,867 ind./m, biomass from 0.02 to 2,114.0 g/m, the average zoobenthos abundance was 3,462 ± 898 ind./m, biomass 133.9 ± 102.0 g/m respectively. The maximum number of taxa was recorded among crustaceans and chironomid larvae. The basis of abundance was formed by oligochaetes and insect larvae, mainly chironomids, mollusks dominated by biomass. The resulting materials can be used as background materials in assessing the impact of construction on the hydrobiological communities of the Lower Don.
The use of anionic flocculant in water treatment for flotation of apatite-nepheline ores
Authors: Artemiev A. V. , Mitrofanova G. V.
Published: August 2020

Currently, an urgent problem is the improvement of methods for purification of industrial water from concentrates of suspended particles and water-soluble impurities using polyacrylamide flocculants. By studying the adsorption processes from aqueous solutions of H and OH ions, the acid-base properties of the surface of the solid phase of the most contaminated technological product have been analyzed, i. e. discharge of the thickener of apatite concentrate, the mineral composition of which is 90 % represented by apatite. The influence of reagents present in the processing technology (fatty acid collector, iron sulfate) on the quantitative ratio of acid-base centers on the surface of apatite has been evaluated. It has been shown that the interaction of these reagents with the mineral creates prerequisites for greater efficiency of the anion-type flocculant. In order to determine the conditions under which flocculants of different types are in the maximally ionized state, studies have been carried out to change the viscosity of the polyelectrolyte solution at different pH values. The position of the isionic point for samples of cationic and anionic flocculants in the presence of reagents used in apatite flotation and dehydration of apatite concentrate has been studied as well. Studies on model and real suspensions in recycled water for a wide range of cationic and anionic flocculants have been performed. Kinetic and concentration dependencies of flocculating capacity of analyzed reagents have been determined; the experiments have confirmed the more efficient operation of anionic-type reagents. The search for the most effective reagents will make it possible to provide optimal water values for the content of suspended particles and hardness cations when introducing closed water circulation technology.
Correlation between the material constitution components in apatite-nepheline ores of the Khybiny Rock Massif (the Kola Peninsula)
Authors: Marchevskaya V. V. , Korneeva U. V.
Published: August 2020

Raw apatite-nepheline ores of the Khibiny alkaline massif are similar in terms of the set of ore-forming minerals and differ in their quantitative ratio. A special place among apatite-nepheline ores is occupied by ores of tectonically destroyed zones, which are widespread in the Khibiny apatite-nepheline deposits. Destruction zone ores are product of secondary changes in raw ores and are characterized by the presence of finely dispersed secondary minerals represented by hydrated micas, zeolites and clay minerals. In the aquatic environment they form colloidal sediments with active surface properties. This fact, as well as thin films of clay and other minerals formed on the surface of apatite grains, cause a decrease in the degree of hydrophobicity of fluorapatite and deterioration of the selectivity of apatite flotation. According to the analytical determinations of the chemical components of the ores and their mineralogical composition, a correlation-regression analysis of the ratio of the components of the material composition of the ores has been performed. The results of correlation-regression analysis have shown that the presence of hypergenically changed ores related to difficult-to-treat ones can be identified by lower ratios of sodium and potassium oxides, as well as sodium and aluminum relative to their average. The presence of products of nepheline change in all ores processed has allowed revealing the most stable correlation between nepheline and sodium oxide, rather than aluminum oxides, in contrast to the earlier opinion. The very high correlation relationship between fluorapatite, nepheline, and titanite and the oxides of phosphorus, sodium, and titanium, respectively, and the statistical significance of the correlation and regression coefficients allow determining the content of these minerals using the regression equations presented in the paper.
Video 7: Strengthening Structures
Authors: Schudel Ingrid , Timmermans Anna
Published: August 2020

This demonstration video, for use in a primary school technology classroom, shows how strong structures can be made using triangular shapes. It then proceeds to challenge learners to make a tower from 20cm straws or other material of similar lengths. The tower needs to be able to hold a tennis ball (or object of a similar size and mass) 30cm above a surface.
The intervening role of ambidexterity in the knowledge management project success connection
Authors: Alshawabkeh Rawan , Abu Rumman Amani , Al-Abbadi Lina , Abu-Rumman Ayman
Published: August 2020

Enhanced positive outcomes and benefits require project management to be integrated with knowledge management (KM) to induce ambidexterity and project success. To offer an empirical insight into this issue and advance the field of knowledge further, this research studies the mediating role of ambidexterity within the KM project success connection. The data collected from a sample of 350 senior people who have familiarity with relevant capital projects in the manufacturing companies in Jordan were analyzed using the algorithm of partial least squares (PLS) and bootstrapping techniques. The findings of the study show that KM is an integral aspect of project success, and it has a significant positive effect on project success, but KM, which does not induce ambidexterity, could not significantly enhance project success. KM can induce and stimulate enhanced project performance and benefits only when it induces ambidexterity. This implies that project success requires KM, given that KM allows organizations to possess exploitative and explorative capabilities simultaneously to tackle issues arising from the external environment. That this study covers only the manufacturing sector in Jordan, the research model can be replicated in other contexts to solidify the findings of the current study.
3D And 2D RNA Structure Prediction Of The BRCA2 Gene And Its Silencing RNA In The Breast Cancer
Authors: Wijaya Ryan , Parikesit Arli Aditya , Nurdiansyah Rizky
Published: August 2020

Breast cancer is one of the most threatening diseases for women. It is found that BRCA2 gene plays a significant role in breast cancer, provided that mutations occurred. The objective of this study is to determine whether the bioinformatics approach could provide the gene networking, molecular simulation, and computational metabolomics information to shed the relation between BRCA2 gene mutation with breast cancer progression. The methods are utilizing molecular simulation tools to comprehend the biochemical interaction of BRCA2 gene with other oncogenic genes. Lastly, the molecular docking tool is devised to provide the molecular interactions information. It could be implied that the Computer-Aided Drug Design (CADD)-based in silico transcriptomics tools could provide the fine-grained information on the exact role of BRCA2 gene in the progression of breast cancer. The clinical impact of this study could only be measured after the wet laboratory experiment is conducted to validate the computational approach results
Effects of Temperature and Aeration on The Dissolved Oxygen (DO) Values in Freshwater Using Simple Water Bath Reactor: A Brief Report
Authors: Febiyanto Febiyanto
Published: August 2020

This work investigated the effect of temperature and aeration treatments on the dissolved oxygen (DO) values in freshwater. The study was carried out using a simple water bath reactor in room temperature condition. Based on the results, freshwater sample without the aeration and temperature treatments (control) indicates a fluctuating profile on which the obtained values of DO were 4.21-4.98 mg/L at Taverage = 27.7 °C. However, the aeration treatment was slightly able to enhance the DO value up to 8.12 mg/L from the initial concentration of 3.88 mg/L at Taverage = 27.4 °C. Compared to the aeration treatment, the addition of temperature treatment has extremely increased the DO value up to 21 mg/L from 6.6 mg/L (T0 minutes = 27 °C)  for 20 minutes of DO observation (T20 minutes = 12.4 °C). Hence, this brief report suggests that the addition of temperature treatment gave a significant effect on the DO value in freshwater than the aeration treatment and control.
Pengaruh Penambahan Arang Aktif Limbah Tongkol Jagung Untuk Mengurangi Kadar Kesadahan Total
Authors: Kusuma Awwalunisa Aliya , Lathifaturrohmah Binti , Dyah Lestari Eka Erfiana
Published: August 2020

Kesadahan total dalam air adalah jumlah kalsium dan magnesium yang terlarut dalam air. Tujuan dari penelitian ini adalah untuk mengetahui kadar kesadahan sebelum serta sesudah perlakuan dengan penambahan absorben berupa arang aktif tongkol jagung. Dilakukan uji aktivitasi arang aktif dari tongkol jagung pada sampel air tanah di lingkungan Kecamatan Cepu dengan menggunakan metode kompleksometri. Kadar kesadahan total sesudah perlakuan dengan penambahan absorben menurun. Kadar rata-rata kesadahan air sumur dari 3 sampel lokasi yang diteliti sebelum perlakuan 344,376 mg/L setelah perlakuan menjadi 216,765 mg/L. Berdasarkan hasil penelitian dapat diketahui bahwa penggunaan karbon aktif tongkol jagung dapat memberikan pengaruh terhadap penurunan tingkat kekeruhan serta kesadahan air tanah di lingkungan Kecamatan Cepu.
Secondary Computer Science Teachers’ Pedagogical Needs
Authors: Sadik Olgun , Ottenbreit-Leftwich Anne , Brush Thomas
Published: August 2020

The purpose of this study is to identify secondary computer science (CS) teachers’ pedagogical needs in the United States. Participants were selected from secondary teachers who were teaching CS courses or content in a school setting (public, private, or charter) or an after-school program during the time of data collection. This is a qualitative study using CS teachers’ discussions in Computer Science Teachers Association’s (CSTA) email listserv, responses to open-ended questions in a questionnaire, and discussions in follow-up interviews. Content analysis, thematic analysis and constant comparative method of qualitative data analysis were used to analyze the data. The most common pedagogical need expressed was learning student-centered strategies for teaching CS and guiding students’ understanding with the use of scaffolding and team-management strategies in CS classes. Furthermore, addressing students’ beliefs in CS and their preconceptions in math and reading were important factors influencing teaching CS effectively in secondary schools.
Diyarbakır İli Odonata Faunası
Authors: DEMİR AYDIN Derya , BOLU Halil
Published: August 2020

Bu çalışma, Diyarbakır (Bağlar, Kayapınar, Sur ve Yenişehir ilçeleri) ilinde 2017 yılının Mayıs, Haziran, Temmuz ile Ağustos aylarında yapılmıştır. Yapılan sörvey çalışmaları sonucunda Odonata takımına bağlı 261 örnek toplanmıştır. Odonata takımına bağlı 3 familyaya ait 7 tür saptanmıştır. Bu türler; Libellulidae familyasından; Brachythemis fuscopalliata (Selys, 1887), Crocothemis erythraea (Brullé, 1832), Orthetrum albistylum (Selys, 1848), O. brunneum (Fonscolombe, 1837), O. coerulescens (Fabricius, 1798), Platycnemididae familyasından; Platycnemis dealbata Klug, 1863 ve Coenagrionidae familyasından; Ischnura elegans (Vander Linden, 1820)’dır. Çalışmada belirlenen 7 türden 6’sının Diyarbakır böcek faunası için ilk kayıt niteliğinde olduğu belirlenmiştir.
Bazı Yağlık Ayçiçeği (Helianthus annuus L.) Çeşitlerinin Önemli Kalite Özelliklerinin Tespiti Üzerine Bir Araştırma
Authors: KAYA Ali Rahmi , ERYİĞİT Tamer
Published: August 2020

Bu denemede, Kahramanmaraş şartlarında yetiştirilen 10 farklı yağlık ayçiçeği (Helianthus annuus L.) çeşidinde kalite özelliklerinin belirlenmesi amaçlanmıştır. Çalışma Kahramanmaraş Doğu Akdeniz Geçit Kuşağı Tarımsal Araştırma Enstitüsüne ait deneme arazisinde 2016 yılında yürütülmüştür. Denemede materyal olarak Coral, 13 TR 001, P64G46, Saray, LG 5580, Bosfora, SY Cadix, Goldsun, P 64LL 05, Tarsan 1018 yağlık ayçiçeği çeşitleri kullanılmıştır. Denemede, yağ oranı, miristik asit, palmitik asit, palmiteloik asit, heptadesenoik asit, stearik asit, oleik asit, linoleik asit, linolenik asit, araşidik asit, eikosenoik (gadoleik) asit, behenik asit ve lignoserik asit oranları, yağ stabilite değerlerinden O/L (oleik asit/linoleik asit) oranı, iyodin değeri ((%P x 1.001) + (%O x 0.899) + (%L x 1.814)), yağ kalite faktörlerinden U/S (doymamış yağ asitleri/doymuş yağ asitleri) oranı, yüz dane ağırlığı ve dane verimi incelenmiştir. Araştırmada elde edilen sonuçlara göre, İncelenen özellikler bakımında çeşitler arasındaki farklılıkların tümü önemli bulunmuştur. Elde edilen sonuçlar, çeşitlerin yağ oranının %38.12-%43.55, oleik asit içeriğinin %46.96 - %86.38, linoleik asit içeriğinin %7.45 - %44.92, linolenik asit içeriğinin %0.205 - %0.307, dane veriminin ise 1782 kg ha-1 - 3178 kg ha-1 arasında değiştiğini göstermiştir. Yağ oranı % 43.55 ile en yüksek olan Tarsan 1018 çeşidinde stearik asit (%4.202) ve linolenik asit (%0.307) en yüksek bulunurken, U/S oranı (%8.81) ve dane verimi (1782 kg ha-1) en düşük bulunmuştur. P64G46 çeşidinde dane verimi (3178 kg ha-1), linoleik asit (% 44.92) ve İD (123.79) en yüksek bulunmuş, yine 13 TR 001 çeşidinde ise heptadesenoik asit (%0.099), oleik asit (%86.38), eikosenoik asit (%0.224), lignoserik asit (%0.340), O/L oranı (%11.71) ve U/S oranı (%11.93) en yüksek bulunmuştur.
Humik Asitin Baklada (Vicia faba L.) Tuz (NaCl) Stresinin Azaltılması Üzerine Etkisi
Authors: TUNÇTÜRK Murat , TUNÇTÜRK Rüveyde , ORAL Erol , BARAN İshak
Published: August 2020

Bu çalışma, farklı tuz (NaCl) dozu uygulamaları (kontrol, 50, 100 ve 150 mM) altında yetiştirilen baklada (Vicia faba L.) humik asit uygulamalarının (kontrol, 50, 100 ve 200 ppm) bitkide bazı fizyolojik ve biyokimyasal parametreler üzerindeki etkilerini belirlemek amacıyla yapılmıştır. Bakla bitkisinin kök ve gövde uzunluğu, kök ve gövde yaş ağırlığı, kök ve gövde kuru ağırlığı, yaprak alanı, yaprak klorofil miktarı, yaprak dokularında iyon sızıntısı, yaprak dokularında membran dayanıklılık indeksi ve malondialdehit (MDA) düzeyi gibi parametreler incelenmiştir. Çalışma sonucunda; tuz stresinin incelenen tüm parametreler üzerine olan etkisi istatistiksel olarak önemli bulunmuştur. Tuz stresi koşullarının yaprak dokularında iyon sızıntısı ve MDA dışındaki tüm parametrelerde azalışlara neden olduğu tespit edilmiştir. Humik asit uygulamasının incelenen tüm parametreler üzerindeki etkisi istatistiksel olarak önemli bulunmuştur (p<0.05 ve p<0.01).
Modified particle swarm algorithm for the optimal water allocation of reservoir
Authors: Gong Zhihao , Cheng Jilin , Gong Yi , Wang Liang , Wei Cong
Published: August 2020

At present, meta-heuristic algorithms are the most popular methods for the optimization of the operations of reservoirs. In order to avoid inappropriate solutions, i.e. spills occurring when the reservoir is not full, a modified method is proposed that can adjust the trajectories of the particles, using the particle swarm algorithm, according to the operation rule of the reservoir. The method was tested in a case study, and was compared to two commonly used methods for generating particle position vectors. These included the direct method, which uses water supply and water spills as the iteration variables, and the indirect method, which uses water storages (water levels) as the iteration variables. The results showed that the three methods could achieve similar solutions at the 75% probability of exceedance. There was no difference in the convergence speeds or the final objective function values of the three models. However, at the 50% probability of exceedance, the modified method produced results that followed the operation rule of the reservoir, whereas the other two methods could lead to inappropriate water spills. This new method may provide a reference for other meta-heuristic algorithms in models of the optimal operation of reservoirs.
Characterisation of floc size, effective density and sedimentation under various flocculation mechanisms
Authors: Fan Yuping , Ma Xiaomin , Dong Xianshu , Feng Zeyu , Dong Yingdi
Published: August 2020

Floc structure plays an important role in the separation of coal wastewater. In this study, a camera-based method is used to evaluate quantitatively the structural characteristics of flocs generated by different coagulants and flocculants. The correlations between particle size, settlement velocity and effective density of coal tailings flocs are analysed. The results show that the statistical settling velocity increases linearly with floc size, while the effective density decreases with increase in floc size. Different flocculation mechanisms lead to diverse growth abilities of flocs. When the flocculant is used alone, the quality of the flocs generated by the flocculants, cationic polyacrylamide (CPAM) and non-ionic polyacrylamide (NPAM), is better than that generated by anionic polyacrylamide (APAM). However, the combination of trivalent cations and APAM yields a much better effect than that obtained using CPAM and NPAM. Flocs become larger and more compact when treated with a coagulant combined with a flocculant.
INFORMATIONAL INSCRIPTIONS AND SIGNS ON THE OBJECTS OF THE CULTURAL HERITAGE OF FEDERAL SIGNIFICANCE IN THE CITY OF TYUMEN
Authors: Gogolev Dmitrii A. , Makarova Elena O.
Published: August 2020

The historical part of Tyumen is a sociocultural space that attracts residents and tourists with the presence of architectural monuments. Among them, the objects of cultural heritage of federal significance are of particular importance for the history and culture of Russia.
Informational inscriptions and signs serve as a source of information about historical buildings included into the Unified State Register of Cultural Heritage Sites (historical and cultural monuments) of the peoples of the Russian Federation.
This topic has not been sufficiently studied in the academic literature. The inscriptions are rarely the subject of research, and they receive little attention in regional publications on memorial data. Filling this void is the purpose of this article.
The research methodology includes the general principles of objectivity and historicism. Using analysis, descriptive and comparative-historical methods, the authors evaluate the content of the inscriptions on the subject of their compliance to the historical truth.
This article identifies quantitative and qualitative indicators related to inscriptions on objects of cultural heritage of federal significance in Tyumen. The quantitative characteristics include the presence, absence, inaccessibility of plates at objects, while the qualitative indicators — certain clusters of information about them.
The authors propose to distinguish two groups of inscriptions depending on the date of their installation. The first group includes those that, for various indicators, do not meet the contemporary requirements. Most likely, they were placed at the facilities before the introduction of the current standards. The second group includes those established in accordance with applicable law.
In the conclusion, the authors suggest correcting the texts of the inscriptions in the future, based on the contemporary legislative framework.