bluuebunny/crossref_metadata_2025 huggingface dataset:
ROLE CONTRADICATIONS BETWEEN CONSULTANTS OF ACCOUNTANT SERVICES AND PUBLIC ACCOUNTANT OFFICES
Authors: Santi Fitriana , Anggraeni Ary Yunita
Published: October 2019

Abstract The Office of Accountant Services is an accounting services office that is allowed to provide management services, taxation and assurance service. The thing that distinguishesbetween KJA and KAP is where the Public Accountant Office is allowed to provide assurance and audit services. In practice there was a dualism of work where the services provided by KJA could also be provided by KAP. While the services provided by KAP cannot be provided by KJA. This is what results in the intersection of interests between KAP and KJA. The reason for the struggle for market share is also their basis for fighting over clients. If thiscontinues, they are not impossible to not focus on the quality of services provided. The writing of this article explains the intersection between these two accounting service offices.Where there is a mental accounting theory that is the background of the dispute between these two service offices.
Peran Optimisme Beretika Dalam Memediasi Partisipasi Anggaran Dan Desentralisasi Terhadap Kinerja Manajerial Pemerintahan
Authors: Soleman Rusman , Arilaha Muhammad Asril , Kahar Suleman H. A.
Published: October 2019

Penelitian ini bertujuan untuk menguji secara empiris peran optimisme etis dalam memediasi partisipasi anggaran dan desentralisasi menuju kinerja manajerial dengan mengambil objek studi di Kota Tidore. Populasi 29 unit kerja pemerintah daerah Kota Tidore diambil dengan teknik purposive sampling. Analisis data dalam penelitian ini menggunakan penelitian ini menggunakan metode analisis data menggunakan perangkat lunak SmartPLS versi 2.0.m3. Hasil penelitian menunjukkan bahwa desentralisasi tidak mempengaruhi kinerja manajerial di unit kerja pemerintah kota Tidore, dan bahwa desentralisasi mempengaruhi optimisme etis di Kota Tidore, Indonesia. Temuan lebih lanjut mengungkapkan bahwa optimisme etis mempengaruhi kinerja manajerial di unit kerja pemerintah kota Tidore. Dalam konteks partisipasi anggaran, itu tidak mempengaruhi kinerja manajerial di unit kerja pemerintah kota Tidore, sementara itu mempengaruhi kinerja manajerial di unit kerja pemerintah kota Tidore.
The Effect of Initial Creep Damage on Unloading Failure Properties of Sandstone from Macro-mesoscopic Perspective
Authors: Wang Yu , Qiao Qingning , Li Jianlin
Published: October 2019

The aim of this research was to show the effect of initial creep damage on unloading failure of rock from macro-mesoscopic perspective. A series of triaxial creep tests were carried out on sandstone to simulate initial creep damage and then unloading confining pressure tests were performed, respectively. A creep damage variable was proposed to analyze the degree of initial creep damage and the relationship of it with the macroscopic strength parameters was established. The results showed that the unloading amount of confining pressure and residual strength all tend to decrease when the degree of initial creep damage increases. The critical challenge was how to describe the effect of initial creep damage from mesoscopic perspective. This aim was achieved through two steps. In the first step, the mesoscopic properties were analyzed using experimentally obtained SEM images of the rock samples with different levels of initial creep damage. By comparative analysis of porosities in different magnifications, it can be concluded that porosity can’t reflect the effect of initial creep damage very well, thus, other pore parameters are further proposed. In the second step, three pore parameters were calculated by using the Matlab and IPP software, then, the average value of mean pore diameter is determined as the proper evaluation parameter and, finally, the agreement was verified between the mesoscopic pore parameter and creep damage variable.
Atabeyzadelerin Amasya’nın Siyasi ve Sosyal Tarihindeki Yeri ve Önemi
Authors: BİRSEL VAROL Gözde , ÖZCAN Selim
Published: October 2019

Amasya’da Selçuklu Sultanı II. Gıyaseddin
Mesud’un ve oğlu Gazi Çelebi Taceddin Altunbaş’ın Atabey’i olan Nasıreddin Ahmed
Bey’in soyundan gelenlere Atabeyzâdeler denmiştir. Nasıreddin Ahmed Atabey
1322-1327 yılları arasında beş yıl Amasya Vâlisi olarak görev yapmıştır.
Amasya’da Atabey Medresesi adıyla bilinen medreseyi inşa ettirmiş, bütün arazi
ve emlâkını medreseye vakfetmiştir. Nasıreddin Ahmed Atabey’in oğulları da aynı
şekilde Amasya halkı arasında itibarlı bir mevkii edinmişler ve Amasya’nın
geleceğinde, Osmanlı hâkimiyetini kabul etmek konusunda, basiretli davranış
sergileyenler arasında yer almışlardır. Bu tutumları da ailenin Osmanlı Dönemi’nde
de önemli bir yer edinmelerini sağlamıştır.

Osmanlılar Dönemi’nde de önemli devlet
görevlerinde bulunmuş olan Atabeyzâde ailesi, bireylerinin isimleriyle iki koldan
ilerlemişlerdir. Birincisi ve en meşhur olanı Yörgüç Paşa’dır. Yörgüç Paşa
soyuna mensup olanlar Yörgüç Paşazâde olarak anılmışlardır. İkincisi ise
kardeşi Hızır Paşa’dır. Çocukları Hızır Paşazâde ismiyle tanınmışlardır. Atabeyzâdeler
Amasya’nın siyasi ve idarî hayatında değişik üst düzey devlet hizmetlerinde görev
almışlardır. XV. yüzyılda şehzâde lalası olmak Atabeyzâdeler’e mahsus bir görev
hâline gelmişti. Atabeyzâdeler Amasya’da inşa ettirdikleri eğitim, dinî ve sosyal
yapılarla da sosyal hayatın gelişimine de katkıda bulunmuşlardır.
Being an Insider and/or Outsider in Feminist Research: Reflexivity as a Bridge Between Academia and Activism
Authors: DİNÇER Pelin
Published: October 2019

Despite the ‘objectivity’ requisite of classic positivist approaches for the research to be considered as ‘scientific’, feminist research stresses the impact of researchers’ positionality within knowledge production and criticises the emphasis on neutrality for a scientific inquiry. Feminists have explored the power relations within the research and discussed the researchers’ position – holding an insider and/or outsider positionality – in terms of their complex relations of power. This examination requires elaboration on reflexivity, a critical stance in feminist research that stresses the situatedness of knowledge, which has a significant potential to eliminate the hierarchy within the research and to reconcile the dichotomy between academia and activism. Thus, this study focuses on the dynamics within the feminist qualitative research, particularly interviewing, the notion of reflexivity, the discussions of researchers’ insider and/or outsider status and how feminist reflexivity can be used as a tool to form a bridge between academia/activism binary.
Dijital Kuşaklar ve Dijital Ortamlar: Türkiye-Kırgızistan Y Kuşağı Örneklemi Üzerine Bir İnceleme
Authors: KIR Serpil
Published: October 2019

İnternetin gelişimi ile birlikte özellikle son yirmi yıl oldukça büyük teknolojik gelişmelere neden olmuş ve günlük hayatımızı farklı şekillerde etkilemeye başlamıştır. Bu gelişim ile birlikte bireylerde de farklı dönüşümler yaşanmış ve bu dönüşümleri anlamlandırabilmek oldukça zorlaşmıştır. Dijital ortamlarda ve sosyal medyada hayatlarının büyük bir kısmını geçiren ve Y kuşağı olarak adlandırılan bu yeni nesli anlamak ve alışkanlıklarını kavrayabilmek iletişim açısından oldukça önemlidir. Bu çalışmada da bireyin teknoloji ile olan ilişkisi temelinden yola çıkılarak Y kuşağının dijital ortamları kullanım alışkanlıkları belirlenmeye çalışılmıştır. Ülkemizde yayınlanan popüler çalışmalar genellikle bilişim teknolojilerine ve sosyal medya platformlarına göreceli olarak sınırsız erişim sağlanması dolayısıyla nispeten belirli sosyo-ekonomik statüye sahip bireylerin dijital ortam kullanım modellerine odaklanmıştır. Bu anlamda bu çalışmada dijital ortam kullanımının kültür ve teknolojik altyapıdaki farklılıklar nedeniyle Kırgızistan’dan farklı olduğu düşünülmüş ve iki ülkenin başkentlerinde yaşayan, Y kuşağı bireylerinin dijital ortamları kullanım alışkanlıklarının incelenmesi amaçlanmıştır. Ekim-Aralık 2018 tarihleri arasında 1100 adet online katılımın sağlandığı çalışma, iki ülkenin başkentlerinde yaşayan Y kuşağı bireylerinin dijital ortamları kullanım alışkanlıklarının ülkeye, cinsiyete, gelir ve eğitim durumuna göre farklılık gösterip göstermediği incelenmiştir.
Elit Tekvandocularda Durumluk ve Sürekli Kaygının Araştırılması
Authors: Öntürk Yavuz , İmamoğlu Osman , KARACABEY Kürşat
Published: October 2019

Amaç:
Bu araştırmada, Tekvandocuların müsabaka öncesi durumluk ve sürekli kaygı
düzeylerinin belirlenmesi amaçlanmıştır. Yöntem:
Araştırmanın örneklemini 748 tekvandocu oluşturmaktadır. Araştırmada kişisel
bilgi formu ile Spielberger’in Sürekli-Durumluk Kaygı Envanteri
kullanılmıştır.  İstatistiksel işlemlerde
t testi, tek yönlü varyans analizi ve LSD testleri kullanılmıştır. Bulgular ve tartışma: Araştırmada
Tekvandocuların durumluk kaygı düzey erkeklerde 62,83 ve kadınlarda 63,61 iken
süreklilik kaygı düzeyi ise erkeklerde 35,50 ve kadınlarda 35,38 puan
ortalamasında oldukları tespit edilmiştir. Cinsiyete göre durumluk kaygı
puanları arasındaki fark istatistiksel olarak anlamlıdır (p<0,05). Eğitim
durumuna göre süreklilik puanlarında bir farklılık bulunmazken durumluk
puanlarında fark olması anlamlıdır (p<0,05). Spor yaşına göre süreklik kaygı
puanlarında anlamlı farklılık varken (p<0,05),  durumluk kaygı puanlarında anlamlı bir
farklılık bulunmamıştır (p>0,05). Sonuç:
Tekvandocularda müsabakalar öncesi durumluk kaygı düzeylerinin yüksek ve
süreklilik kaygı düzeylerinin ise düşük düzeyde olduğu tespit edilmiştir.  Tekvandoculara durumluk kaygıyı azaltıcı çalışmalar
yapılmalıdır.
Lisans Düzeyinde Turizm Rehberliği Eğitimi Alan Öğrencilerin Akademik Motivasyonlarının Mesleğe Dönük Tutumlarına Etkisi
Authors: ESER Seçkin , ÇAKICI A. Celil
Published: October 2019

Çalışmanın amacı lisans düzeyinde turizm rehberliği
eğitimi alan öğrencilerin akademik motivasyonlarının mesleğe dönük tutumlarında
etkisinin belirlenmesidir. Veriler, literatüre dayalı geliştirilen bir anketin
Türkiye’de lisans düzeyinde turizm rehberliği eğitimi alan 1105 öğrenciye
uygulanmasıyla derlenmiştir. Anketler, öğrencilere 2016-2017 eğitim-öğretim
yılı bahar yarıyılında, turizm rehberliği bölümlerinde görevli öğretim
elemanlarının yardımıyla, sınıf bazında kota örneklemesine göre,
10.02-20.03.2017 tarihleri arasında yüz yüze uygulanmıştır. Veriler korelasyon,
faktör ve çoklu regresyon analizine tabi tutulmuştur. Lisans düzeyinde turizm
rehberliği alan öğrencilerin mesleğe dönük olumlu tutum sergiledikleri
belirlenmiştir. Öğrencilerin içsel motivasyonlarının yüksek olduğu, mesleğe
dönük tutumlarını en fazla etkileyen akademik motivasyonun dışsal akademik
motivasyonları olduğu ortaya çıkmıştır. Çalışma, lisans düzeyinde rehberlik
eğitimi alan öğrencilerin, mesleklerine dönük olumlu tutum geliştirmelerine
yönelik çeşitli öneriler ile son bulmaktadır.
Nurturing the Critical Care Concept
Authors: Goonasekera Chulananda , Freebairn Ross
Published: October 2019

Abstract not available

Bangladesh Crit Care J September 2019; 7(2): 63-65
Immunohistochemical Study on Hormone Receptors and HER2 Status in Invasive Breast Carcinoma and its Therapeutic Implications
Authors: Karim Md Iqbal , Islam Md Tarikul , Nargis Nazlima
Published: October 2019

Background: Immunohistochemistry (IHC) has become an integral part of histopathology in the diagnosis of biopsysample. Although haematoxylin and eosin (H & E) stain remains the fundamental basis for diagnostic pathology of thebreast, IHC stains provide useful and sometimes vital information. Moreover, the role of hormonal therapy in hormonereceptor–positive breast tumours, as well as targeted chemotherapeutic agents for human epidermal growth factorreceptor-2 (HER2) positive cases, IHC studies represent a major part of workups.

Objective: The study was carried out to identify the common immunohistochemical markers in invasive breastcarcinoma and to find out the relationship between hormonal receptor status and HER2 over expression with the gradeof tumour and its therapeutic implications.

Method: In the present study, immunohistochemical assay of total seventy-two blocks of breast carcinoma patients wasperformed to know the hormone receptors and HER2 status as well as histological examination.

Result: 72 samples were grouped to study hormonal status and their relation with clinicopathological factors. Outcomeof this study documented 58.33 %, 44.44% and 25 % expression rate of estrogen receptor (ER), progesterone receptor(PR) and human epidermal growth factor receptor-2 (HER2) respectively. The negative expression of HER2 receptorsfound higher (75%) than ER & PR. The ER, PR negative and HER2 Positive cases found in high grade breast cancer(Grade-3). An inverse correlation of HER2 expression with ER and PR expression was observed (p=0.001).

Conclusion: The role of hormone receptors and HER2 repression as a prognostic and therapeutic tool in breast canceris widely accepted and effective for patients.

Bangladesh Crit Care J September 2019; 7(2): 95-98
Acquired Melanonychia and Mucocutaneous Hyper pigmentation with Hydroxyurea Therapy for the Treatment of Blast Crisis of Chronic Myeloid Leukaemia: A Case Report
Authors: Md Atiquzzaman - , Taher Md Abu , Bhattacharyya PK , Begum Momtaz , Islam Tayef Md Tahlil , Alam Shahidul , Akhtar Farzana , Sohan - Md Ashikuzzaman
Published: October 2019

Hydroxyurea is an antineoplastic agent used to treat chronic myeloid leukaemia (especially in accelerated phaseand blast crisis). We report this unique case of a 60 year old lady who was diagnosed case of chronic-phase ofchronic myeloid leukaemia was getting imatinib and well suited. As a consequence of imatinib noncompliance,she developed blast crisis and was subsequently hydroxyurea initiated. At her 3rdmonth follow-up she presentedwith blackening of her exposed parts of the body, all three mucocutaneous areas especially skin of her hands, feet,fingernails, toenails and oral mucosa in some extent.Hydroxyurea-induced melanonychia and mucocutaneous hyperpigmentation is rarely reported. To the best of ourknowledge, this is one of the few published reports of hydroxyurea induced mucocutaneous hyperpigmentationand melanonychia involving all 20 nails. The mainstays of treatment are withdrawal of the drug andsun-avoidance; laser therapy is a hope for cure in small percentage of permanent cases. A correct diagnosis isessential to prevent undue fears in the patient. Proper advice to the patient regarding adverse reactions ofparticular agent and close monitoring after prescribing should be ensured to prevent harm to patients. Alwaysshould remember, drugs not only save life, but can even take it.

Bangladesh Crit Care J September 2019; 7(2): 106-108
A case of Leaking Abdominal Aortic Aneurysm
Authors: Haque Rashedul , Faruq Mohammad Omar , Sultana Amina , Rahman Mir Atiqur , Shamarukh Karishma , Hasan S M Razibul
Published: October 2019

Abstract not available

Bangladesh Crit Care J September 2019; 7(2): 116-117
Los caminos desviados de la educación: Alternativas pedagógicas como crítica a la educación formal
Authors: Núñez Arce Beatriz , Silva Prada Diego Fernando , García Serrano Saúl Ernesto
Published: October 2019

El presente artículo realiza un análisis sobre prácticas educativas alternativas a la educación formal como apuesta crítica y creativa, encaminado hacia comprender experiencias significativas del aprendizaje. Primero, se estudia el analfabetismo, desde el caso particular colombiano, como un fenómeno que segrega a la población frente al deber ser de la educación formal. Segundo, se retoma la perspectiva artística para la experiencia educativa, desde el ser la condición natural creativa y sensible de los seres humanos que necesita desarrollarse durante toda su existencia. Finalmente, se muestran algunas experiencias de educación desviada, entendiendo que el objetivo de este tipo de educación no es producir personas exitosas y competitivas, sino formar seres felices y libres. El trabajo parte desde las preguntas: ¿qué enseñar?, ¿cuándo enseñar?, ¿para qué enseñar?, pero, sobre todo, desde el ¿dónde enseñar? Se concluye señalando la emergencia de grupos y prácticas de resistencia educativa y cultural que entienden que el mundo social es un organismo cambiante, y que hay que intentar cambiar el modelo educativo tradicional formal
Bacteriological and Physicochemical Analysis of Groundwater of Kasur
Authors: Abbas Asad , Hussain Ijaz , Wahab Abdul , Shafique Aisha , Zaheer Maryam
Published: October 2019

Earth is a blue planet because of the rudimentary cause of life, that is water. All the biochemical reactions which are pre-requisite for nourishing life of animals and plants, use water as a basic element. Being a universal solvent, it dissolves almost all minerals present in the soil. It is one of the basic and necessary compounds responsible for the survival of life. The main purpose of research was to determine the quality of groundwater in Kasur near the tanneries. The study is focused on the bacteriological and physicochemical (pH, Temperature, DO, BOD, CO2, TOSM, TDS, TM and heavy metals) parameters. We selected four sites as Din Garh, Qatal Garhi, Mangal Mandi and Kot Haleem Khan for investigation. Coliforms were present in high concentration that produce viruses and bacterial diseases such as typhoid fever, hepatitis, gastrocnemii, dysentery and ear infections. World Health Organization (WHO) has justified that the drinkable water must have zero level of coliform and E.coli. Regarding the Total Suspended Matter (TSM), the values ranged from 0.3-0.5g/l in DIN GHARH, 0.2-0.5g/l in QATAL GHARHI, 0.2-0.5g/l in MANGAL MANDI and 0.2-0.6g/l in KOT HALEEM KHAN. The study concludes that the water pollution due to tanneries in Kasur have changed the bacteriological and physicochemical properties of ground water to a considerable level which is not drinkable. It also conclude that groundwater was contaminated with high concentrations of BOD, TOSM, TDS, TM and Heavy metals due to discharge of industrial effluents.
A Case of Bony Defect of the Anterior External Auditory Canal Wall Causing Ear Fullness
Authors: Lee Jong Kyou , Lee Bum Sang , Jang Soo Kyung , Park Su-Kyoung
Published: October 2019

A congenital defect of the anterior wall of the external auditory canal (EAC) is known as foramen of Huschke. The tympanic bone is incompletely developed and has a U shape at birth. The foramen of Huschke closes via continuous bone growth, which occurs before the age of 5 years. A persistent foramen of Huschke is an anatomic variation located in the anteroinferior portion of EAC, which can cause ear discomfort with spontaneous temporomandibular joint (TMJ) herniation into the EAC bony defect. We present a case of 50-year-old man who had a symptomatic TMJ herniation through an osseous defect. The physical examination showed a bulging mass of anterioinferior portion of EAC when the patient closed his mouth, which was retracted when the mouth openned. We report a case of surgical reconstruction of the EAC wall defect, and the foramen of Huschke with titanium mesh via preauricular approach along with literature’s review.
HUBUNGAN DARI MOTIVASI DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN PT GENERASI KREATIF MUDA INDONESIA
Authors: Desya Calista Sarah
Published: October 2019

This research about the relationship from motivation and work environmental to the perfomance of employee PT Generasi Kreatif Muda Indonesia. This research is a knowledge to know whether there is correlation of motivation and work environmental to the employeeâ€™s perfomance. The method of the research used is quantitaive method and used the set of a questionnaire. Population and sample of the research are 34 people. The questionnaire was given to the sample. After data was collected, then it was analyzed, and after that finding was drawn, the finding there is correlation of motivate and work environmental to employeeâ€™s perfomance. In order to maintain and improve employeeâ€™s perfomance,  motivation and work environment PT Generasi Kreatif Muda Indonesia are important element that needs to more concern.
Keywords: Motivation, Work Environment, and Employee Perfomance
KONFIGURASI JALUR PEDESTRIAN YANG PERMEABLE DI DALAM AREA BARRIER ANTARA KAWASAN BANGKITAN DAN TARIKAN
Authors: Wafirul Aqli Wafirul
Published: October 2019

The MH Thamrin Central Jakarta road area is an office area adjacent to residential areas in all its socio-economic levels. With the configuration of access to the existing road spaces, office blocks become barrier  for residential areas as generated when  they are related to  the MRT station as pulled of movement. This problem is the background of this research, so that a solution that is found to be effective in making this office block more permeable to access existing MRT stations. In walking activities, shorter travel times and increased mobility can be obtained by the existence of environmental permeability to the movement actors who in this case are pedestrians themselves. Environmental permeability is created from factors such as connectivity and accessibility. Based on the theory, and with the space syntax simulation method using the DepthmapX application, this study was designed to identify  accessibility condition of  the area being the case study, and also to find a more permeable configuration from the generated area to the pulled area through the barrier.
PENGEMBANGAN MODEL RESIPROCAL, EXAMPLE NON EXAMPLE, DAN MIND MAPPING (REXMIND) UNTUK MENGOPTIMALISASI HASIL PEMBELAJARAN ILMU PENGETAHUAN SOSIAL (IPS) DI KELAS VII
Authors: Sariningsih Sri , Yusuf Adi E , Sutisna Entis , Laihad Griet Helena
Published: October 2019

Tujuan penelitian ini untuk mengoptimalisasi  hasil pembelajaran ilmu pengetahuan sosial (ips)  di kelas VII melalui pengembangan model resiprocal, example non example, dan mindmapping (rexmind).  Penelitian ini digolongkan ke dalam penelitian Research and Development (R&D) dengan menggabungkan Model pembelajaran Reciprocal, Example Non-Example, dan Mind Mapping. Uji coba terbatas dilaksanakan di SMPN 1 Cireunghas dengan 36 SISWA,  dan uji coba luas di SMPN 1 Nyalindung dengan 36 siswa dan SMPN 3 Nyalindung  dengan 23 siswa.  Metode yang digunakan adalah metode survey dan teknik pengumpulan data kualitatif dan kuantitatif. Penilaian hasil belajar siswa pada uji coba terbatas  pada ranah kognitif adalah 91.67 %, afektif adalah 87 %, psikomotor 88 % dan antusiasme siswa 88.7% dengan KKM 70. Penilaian hasil belajar siswa pada uji coba luas pada ranah kognitif adalah 94.44 %, afektif adalah 89 %, psikomotor 91 % dan antusiasme siswa 92% dengan KKM 70. Penilaian hasil belajar siswa pada uji coba luas pada ranah kognitif adalah 91.3 %, afektif  85 %, psikomotor 86 % dan antusiasme siswa 92.50 % dengan KKM 70. Penelitian ini merekomendasikan bahwa Pengembangan Model REXMIND pada Mata Pelajaran IPS Se-Komisariat Sukaraja (Reciprocal, Example Non-Example, dan Mind Mapping) berhasil meningkatkan hasil belajar baik secara kognitif, afektif, psikomotorik dan antusiasme siswa . Penelitian Research and Development (R & D) ini menghasilkan model pembelajaran baru yang terekomendasi yaitu Model REXMIND (Reciprocal, Example Non-Example, dan Mind Mapping).
HUBUNGAN ANTARA BUDAYA SEKOLAH DAN KOMPETENSI PEDAGOGIK DENGAN KREATIVITAS GURU
Authors: Umyati Umyati , Sumardi Sumardi , Suhardi Eka
Published: October 2019

Penelitian ini bertujuan untuk mengetahui hubungan antara budaya sekolah dan kompetensi pedagogik guru dengan kreativitas guru secara sendiri-sendiri dan secara bersama-sama. Penelitian kuantitatif ini merupakan penelitian survei dengan pendekatan korelasional yang terdiri atas dua variabel bebas, yaitu budaya sekolah dan kompetensi pedagogik serta kreativitas guru sebagai variabel terikat. Penelitian ini dilaksanakan di SD Negeri di Kecamatan Cileungsi Kabupaten Bogor pada tahun 2017. Jumlah sampel penelitian sebanyak 152 orang guru PNS yang diambil secara proportional random sampling dari populasi sebanyak 245 guru SDN. Temuan dalam penelitian ini yaitu terdapat hubungan positif yang sangat signifikan antara budaya sekolah dengan kreativitas guru, terdapat hubungan positif yang sangat signifikan antara kompetensi pedagogik guru dengan kreativitas guru dan Terdapat hubungan yang sangat signifikan antara budaya sekolah dan kompetensi pedagogik guru secara bersamasama dengan kreativitas guru. Kesimpulan dari penelitian ini yaitu kreativitas guru dapat ditingkatkan dengan budaya sekolah dan kompetensi pedagogik guru secara sendiri-sendiri dan secara bersama-sama. Kata kunci: Budaya sekolah, kompetensi pedagogik, dan kreativitas guru
MENINGKATKAN KETERAMPILAN BERPIKIR KRITIS DAN KREATIF SISWA MELALUI PEMBELAJARAN TATA NAMA SENYAWA KIMIA DENGAN MENGGUNAKAN MEDIA PIRINGAN KATION ANION
Authors: Herlina Herlina , Heliawati Leny , Permana Irvan
Published: October 2019

Penelitian ini bertujuan untuk mengetahui sejauh mana pemanfaatan media piringan kation anion dapat membangun keterampilan berpikir kritis dan kreatif siswa pada pembelajaran tata nama senyawa. Metode yang digunakan dalam penelitian ini adalah preeksperimen dengan pre-postest design. Instrumen yang digunakan terdiri dari soal keterampilan berpikir kritis, penilaian observasi keterampilan berpikir kreatif, dan angket respon siswa. Hasil penelitian menunjukkan bahwa pembelajaran yang dikemas dengan model inquiri sesuai dengan tahapan pembelajaran yang direkomendasikan berdasarkan kurikulum 2013, ternyata mampu meningkatkan keterampilan berpikir kritis dan kreatif siswa. Hasil penelitian juga menunjukkan bahwa terdapat korelasi positif antara keterampilan berpikir kritis dengan keterampilan berpikir kreatif dengan korelasi 0,478 (cukup). Siswa juga memberikan respon positif terhadap pembelajaran.
Release of Highly Active Ice Nucleating Biological Particles Associated with Rain
Authors: Iwata Ayumi , Imura Mayu , Hama Moeka , Maki Teruya , Tsuchiya Nozomu , Kunihisa Ryota , Matsuki Atsushi
Published: October 2019

Biological particles may play an important role in the climate system by efficiently acting as ice nucleating particles (INPs) at a higher temperature range (e.g., above −20 °C where representative INPs such as mineral dust remain inactive), but there is an obvious lack of direct evidence that these particles serve in this manner. Here, we collected ambient particles under different weather conditions for identifying INPs that are active above −22 °C. The abundance of such efficient INPs increased during or following rainfall events. The extensive characterization of individual particles by three different analyses (particle morphology and composition, heat sensitivity of ice nucleation activities, and biological fingerprinting by DNA staining) revealed that efficient INPs have distinctly biological characteristics, which differ significantly from more abundant, representative, and relatively less active INPs, such as mineral dust. Additionally, by combining the heat-sensitivity experiments and DNA staining techniques, efficient INPs were found to contain heat-sensitive biomaterials and biological cells. Our findings provide direct evidence that biological particles are preferentially released into the atmosphere during rainfall events and act as important atmospheric INPs at higher temperature ranges (warmer than −22 °C), where typical INPs remain inactive.
Microbial Fortification Improved Photosynthetic Efficiency and Secondary Metabolism in Lycopersicon esculentum Plants Under Cd Stress
Authors: Khanna Kanika , Kohli Sukhmeen Kaur , Ohri Puja , Bhardwaj Renu , Al-Huqail Asma A. , Siddiqui Manzer H. , Alosaimi Ghada Saleh , Ahmad Parvaiz
Published: October 2019

Environmental stress including heavy metal pollution is increasing at high speed and is polluting the cultivable land. Consequently, it results in affecting human population through entering into food chain. The current study aims that Cd stress (0.4 mM) led to toxicity and deleterious effects on 45-day-old Lycopersicon esculentum plants. The use of rhizobacterial strains underlines the main hypothesis of the present research that have been exploited in order to alleviate the Cd induced stress in plants and promoting their growth sidewise. The morphological parameters, plant pigments, and gaseous exchange parameters were estimated and found to be reduced in plants due to Cd toxicity. Along with this, the levels of phenolic compounds and osmoprotectants were stimulated in plants raised in Cd spiked soils. In addition, free amino acid content was reduced in plants under Cd treatment. It was revealed that these bacterial strains Pseudomonas aeruginosa (M1) and Burkholderia gladioli (M2) when inoculated to tomato plants improved the morphological characteristics and enhanced photosynthetic attributes. Moreover, the level of phenolic compounds and osmoprotectants were further enhanced by both the inoculating agents independently. However, in situ localization studies of phenol accumulation in root sections was found to be enhanced in Cd treated plants as revealed through higher intensity of yellowish-brown colour. The supplementation of bacterial strains further accumulated the phenols in Cd stressed root sections as evidenced through increased colour intensity. Therefore, the present study suggested that bacterial strains mitigates Cd stress from tomato plants through improving morphological, physiological and metabolite profiles. Consequently, the present research advocates the best utilization of rhizobacteria as stress alleviators for sustainable agriculture.
Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome Editing
Authors: Reuven Nina , Adler Julia , Broennimann Karin , Myers Nadav , Shaul Yosef
Published: October 2019

CRISPR/Cas9 is a powerful tool for genome editing in cells and organisms. Nevertheless, introducing directed templated changes by homology-directed repair (HDR) requires the cellular DNA repair machinery, such as the MRN complex (Mre11/Rad50/Nbs1). To improve the process, we tailored chimeric constructs of Cas9, in which SpCas9 was fused at its N- or C-terminus to a 126aa intrinsically disordered domain from HSV-1 alkaline nuclease (UL12) that recruits the MRN complex. The chimeric Cas9 constructs were two times more efficient in homology-directed editing of endogenous loci in tissue culture cells. This effect was dependent upon the MRN-recruiting activity of the domain and required lower amounts of the chimeric Cas9 in comparison with unmodified Cas9. The new constructs improved the yield of edited cells when making endogenous point mutations or inserting small tags encoded by oligonucleotide donor DNA (ssODN), and also with larger insertions encoded by plasmid DNA donor templates. Improved editing was achieved with both transfected plasmid-encoded Cas9 constructs as well as recombinant Cas9 protein transfected as ribonucleoprotein complexes. Our strategy was highly efficient in restoring a genetic defect in a cell line, exemplifying the possible implementation of our strategy in gene therapy. These constructs provide a simple approach to improve directed editing.
Bio-Guided Fractionation of Ethanol Extract of Leaves of Esenbeckia alata Kunt (Rutaceae) Led to the Isolation of Two Cytotoxic Quinoline Alkaloids: Evidence of Selectivity Against Leukemia Cells
Authors: Álvarez-Caballero Juan Manuel , Cuca-Suárez Luis Enrique , Coy-Barrera Ericsson
Published: October 2019

Bio-guided fractionation performed on the leaves-derived ethanol extract of Esenbeckia alata (Rutaceae), a plant used in traditional medicine, led to the isolation of two alkaloids, kokusaginine 1 and flindersiamine 2, as main cytotoxic agents. Primary ethanolic extract and raw fractions exhibited cell inhibition against five cancer cell lines at different levels (25–97% inhibition at 50 µg/mL) as well as isolated alkaloids 1–2 (30–90% inhibition at 20 µM). Although alkaloid 2 generally was the most active compound, both alkaloids showed a selective effect on K562, a human chronic myelogenous leukemia cell line. The E1-like ubiquitin-activating enzymes (e.g., UBA5) have been recently described as important targets for future treatment of cancer progression, such as leukemia, among others. Therefore, as a rationale to the observed cytotoxic selectivity, an in-silico evaluation by molecular docking and molecular dynamics was also explored. Compounds 1–2 exhibited good performance on the interaction within the active site of UBA5.
Efficient Degradation of Norfloxacin and Simultaneous Electricity Generation in a Persulfate-Photocatalytic Fuel Cell System
Authors: Li Jiawen , Li Ruizhen , Zou Luomei , Liu Xingyong
Published: October 2019

Photocatalytic fuel cell (PFC) has been verified to be a promising technique to treat organic matter and recover energy synchronously. Sulfate radicals (SO4·−), as a strong oxidant, have obvious advantages in the degradation of refractory pollutants compared with hydroxyl radicals (·OH), which is the dominant radical in PFC. This study reports a coupling method of PFC and persulfate (PS) activation to promote the degradation of antibiotic norfloxacin (NOR) and simultaneous electricity generation. The added PS as an electron acceptor could be activated by photoelectric effects to produce SO4·− at the electrodes-electrolyte interface. In the solution, PS as supporting electrolyte could accelerate the electron transfer and also be activated by ultraviolet (UV) light irradiation, which could extend the radical oxidation reaction to the whole solution and improve the PFC performance. The performance comparison among different systems indicated the excellent synergistic effect of PFC and PS activation for improving NOR degradation and electricity generation. The effects of influencing factors including initial pH, PS concentration, and initial NOR concentration on the degradation of NOR were investigated extensively to find out the optimal conditions. Moreover, according to the results of radical capture experiments, the significantly contribution of both SO4·− and ·OH to the degradation of NOR was demonstrated and a tentative function mechanism for the NOR degradation in the proposed system was provided. Finally, total organic carbon and real wastewater treatment confirmed the high mineralization and practical applicability of the proposed PFC/PS system.
Bifunctional Electrocatalyst of Low-Symmetry Mesoporous Titanium Dioxide Modified with Cobalt Oxide for Oxygen Evolution and Reduction Reactions
Authors: Amer Mabrook S. , Ghanem Mohamed A. , Arunachalam Prabhakarn , Al-Mayouf Abdullah M. , Hadadi Sultan M.
Published: October 2019

Hybrids of low-symmetry (disordered) mesoporous titanium dioxide modified with different weight ratios of cobalt oxide nanoparticles (Co3O4(x)/lsm-TiO2) are prepared using a one-pot self-assembly surfactant template. The physicochemical characterization of Co3O4(x)/lsm-TiO2 hybrids by scanning and transmission electron microscopy, X-ray diffraction, N2 adsorption–desorption isotherms, and X-ray photoelectron spectroscopy confirm the successful incorporation of cobalt oxide nanoparticles (2–3 nm in diameter) with preservation of the highly mesoporous structure of titanium dioxide substrate. Among these mesoporous hybrids, the ~3.0 wt.% Co3O4/lsm-TiO2 exhibits the best performance toward both the oxygen evolution (OER) and reduction (ORR) reactions in alkaline solution. For the OER, the hybrid shows oxidation overpotential of 348 mV at 10 mA cm−2, a turnover frequency (TOF) of 0.034 s−1, a Tafel slope of 54 mV dec−1, and mass activity of 42.0 A g−1 at 370 mV. While for ORR, an onset potential of 0.84 V vs. RHE and OER/ORR overpotential gap (ΔE) of 0.92 V are achieved which is significantly lower than that of commercial Pt/C, hexagonal mesoporous, and bulk titanium dioxide analogous. The Co3O4/lsm-TiO2 hybrid demonstrates significantly higher long-term durability than IrO2. Apparently, such catalytic activity performance originates from the synergetic effect between Co3O4 and TiO2 substrate, in addition to higher charge carrier density and the presence of disordered mesopores which provide short ions diffusion path during the electrocatalytic process.
Increased Serum Parathyroid Hormone, Osteocalcin and Alkaline Phosphatase Are Associated with a Long-Term Adverse Cardiovascular Outcome after Coronary Artery Bypass Graft Surgery
Authors: Barbarash Olga , Zykov Mikhail , Kashtalap Vasiliy , Hryachkova Oksana , Kokov Alexandr , Gruzdeva Olga , Shibanova Irina , Kutikhin Anton
Published: October 2019

Despite the fact that an association of osteopoenia/osteoporosis with elevated risk of coronary artery calcification (CAC) and coronary atherosclerosis (CA) is well-established, it remains unclear whether bone turnover markers can be employed in long-term prognostication of such patients. Here we measured serum calcium, phosphate, calcitonin, parathyroid hormone (PTH), osteoprotegerin, osteocalcin, osteopontin, alkaline phosphatase and its bone isoenzyme, subsequently correlating them with an adverse cardiovascular outcome after 3 years of follow-up. The extent of brachiocephalic artery stenosis, CA, or CAC, as well as prevalence of osteopoenia/osteoporosis before the coronary artery bypass graft (CABG) surgery, did not differ between outcome groups, suggesting that subtle molecular mechanisms might be involved in determining the outcome rather than clinical or subclinical disease. After stepwise logistic regression, serum osteocalcin > 26.8 ng/mL and PTH > 49.1 pg/mL were independent predictors of an adverse outcome. Serum ionised calcium correlated with multivessel coronary artery disease; moreover, patients with severe CA (SYNTAX score > 21) had higher serum ionised calcium than those with mild CA. Likewise, serum alkaline phosphatase was associated with severe CA and CAC (Agatston score > 400). In conclusion, serum PTH, osteocalcin, and alkaline phosphatase are associated with an adverse cardiovascular outcome 3 years after CABG surgery regardless of osteopoenia/osteoporosis, coronary/peripheral atherosclerosis, and CAC.
Using a Reinforcement Q-Learning-Based Deep Neural Network for Playing Video Games
Authors: Lin Cheng-Jian , Jhang Jyun-Yu , Lin Hsueh-Yi , Lee Chin-Ling , Young Kuu-Young
Published: October 2019

This study proposed a reinforcement Q-learning-based deep neural network (RQDNN) that combined a deep principal component analysis network (DPCANet) and Q-learning to determine a playing strategy for video games. Video game images were used as the inputs. The proposed DPCANet was used to initialize the parameters of the convolution kernel and capture the image features automatically. It performs as a deep neural network and requires less computational complexity than traditional convolution neural networks. A reinforcement Q-learning method was used to implement a strategy for playing the video game. Both Flappy Bird and Atari Breakout games were implemented to verify the proposed method in this study. Experimental results showed that the scores of our proposed RQDNN were better than those of human players and other methods. In addition, the training time of the proposed RQDNN was also far less than other methods.
K-Band Low Phase Noise VCO Based on Q-Boosted Switched Inductor
Authors: Chen Zhe , Chen Ji-Xin , Yan Pinpin , Hou Debin , Zhu Fang
Published: October 2019

In this article, the development of the K-band low phase noise voltage-controlled oscillator (VCO) based on Q-boosted switched inductor is presented. Compared with the conventional switched inductor, the eddy current will be decreased using a 2-turn secondary coil, and then the dissipated power from the switch on-resistance will also be decreased, leading to a boosted inductor Q at switch ON-state. The equivalent inductance, quality factor, and self-resonance frequency at switch ON/OFF states are analyzed and derived. For comparison, K-band VCOs have been designed and fabricated in a 130nm BiCMOS process with the Q-boosted and conventional switched inductors. Measured results show that the phase noise has been typically improved by 2–5dB at 100 kHz and 1 MHz offset at switch ON-state, using the Q-boosted switched inductor.
Leaching Behavior of As, Pb, Ni, Fe, and Mn from Subsurface Marine and Nonmarine Depositional Environment in Central Kanto Plain, Japan
Authors: Hossain Sushmita , Ishiyama Takashi , Hachinohe Shoichi , Oguchi Chiaki T.
Published: October 2019

The leaching behavior of arsenic (As), lead (Pb), nickel (Ni), iron (Fe), and manganese (Mn) was investigated from subsurface core sediment of marine and nonmarine depositional environments in central Kanto Plain, Japan. A four-step sequential extraction technique was adopted to determine the chemical speciation, potential mobility, and bioavailability of metals under natural conditions in variable depositional environments. In addition, a correlation of these properties with pore water and total metal content was carried out. The concentration of As in pore water was found to be 2–3 times higher than the permissible limit (10 µg/L) for drinking water and leachate in fluvial, transitional, and marine environments. The trend of potential mobile fractions of As, Pb, and Ni showed Fe–Mn oxide bound > carbonate bound > ion exchangeable bound > water soluble in the fluvial environment. However, in the marine environment, it showed Fe–Mn oxide bound > water soluble > carbonate bound > ion exchangeable bound for As. The leaching of As in this fluvial environment is due to the organic matter-mediated, reductive dissolution of Fe–Mn oxide bound, where Mn is the scavenger. The amount of total content of As and sulfur (S) in transitional sediment reflects an elevated level of leachate in pore water, which is controlled by S reduction. However, the leaching of As in marine sediment is controlled by pH and organic matter content.
Tele–Robotic Platform for Dexterous Optical Single-Cell Manipulation
Authors: Gerena Edison , Legendre Florent , Molawade Akshay , Vitry Youen , Régnier Stéphane , Haliyo Sinan
Published: October 2019

Single-cell manipulation is considered a key technology in biomedical research. However, the lack of intuitive and effective systems makes this technology less accessible. We propose a new tele–robotic solution for dexterous cell manipulation through optical tweezers. A slave-device consists of a combination of robot-assisted stages and a high-speed multi-trap technique. It allows for the manipulation of more than 15 optical traps in a large workspace with nanometric resolution. A master-device (6+1 degree of freedom (DoF)) is employed to control the 3D position of optical traps in different arrangements for specific purposes. Precision and efficiency studies are carried out with trajectory control tasks. Three state-of-the-art experiments were performed to verify the efficiency of the proposed platform. First, the reliable 3D rotation of a cell is demonstrated. Secondly, a six-DoF teleoperated optical-robot is used to transport a cluster of cells. Finally, a single-cell is dexterously manipulated through an optical-robot with a fork end-effector. Results illustrate the capability to perform complex tasks in efficient and intuitive ways, opening possibilities for new biomedical applications.
Role of primary care in supporting older adults who self-harm: a qualitative study in England
Authors: Troya M Isabela , Chew-Graham Carolyn A , Babatunde Opeyemi , Bartlam Bernadette , Mughal Faraz , Dikomitis Lisa
Published: October 2019

Background

Self-harm and suicide are major public health concerns. Self-harm is the strongest risk factor for suicide, with the highest suicide rates reported in older populations. Little is known about how older adults access care following self-harm, but they are in frequent contact with primary care.

Aim

To identify and explore barriers and facilitators to accessing care within primary care for older adults who self-harm.

Design and setting

An exploratory qualitative methods study using semi-structured interviews with older adults and third-sector workers in England. Older adults were invited to participate in one follow-up interview.

Method

Interviews occurred between September 2017 and September 2018. These were audio-recorded, transcribed verbatim, and data analysed thematically. A patient and public involvement and engagement group contributed to the study design, data analysis, and interpretation.

Results

A total of 24 interviews with nine older adults and seven support workers, including eight follow-up interviews with older adults, were conducted. Three themes emerged: help-seeking decision factors; sources of support; and barriers and facilitators to accessing primary care.

Conclusion

Despite older adults’ frequent contact with GPs, barriers to primary care existed, which included stigma, previous negative experiences, and practical barriers such as mobility restrictions. Older adults’ help-seeking behaviour was facilitated by previous positive experiences. Primary care is a potential avenue for delivering effective self-harm support, management, and suicide prevention in older adults. Given the complex nature of self-harm, there is a need for primary care to work with other sectors to provide comprehensive support to older adults who self-harm.
Educational intervention to optimise serum immunoglobulin test use in Irish primary care: an interrupted time series with segmented regression analysis
Authors: Cadogan Sharon L , Browne John P , Bradley Colin P , Fitzgerald Anthony P , Cahill Mary R
Published: October 2019

Background

Implementation science experts recommend that theory-based strategies, developed in collaboration with healthcare professionals, have greater chance of success.

Aim

This study evaluated the impact of a theory-based strategy for optimising the use of serum immunoglobulin testing in primary care.

Design and setting

An interrupted time series with segmented regression analysis in the Cork–Kerry region, Ireland. An intervention was devised comprising a guideline and educational messages-based strategy targeting previously identified GP concerns relevant to testing for serum immunoglobulins.

Method

Interrupted time series with segmented regression analysis was conducted to evaluate the intervention, using routine laboratory data from January 2012 to October 2016. Data were organised into fortnightly segments (96 time points pre-intervention and 26 post-intervention) and analysed using incidence rate ratios with their corresponding 95% confidence intervals.

Results

In the most parsimonious model, the change in trend before and after the introduction of the intervention was statistically significant. In the 1-year period following the implementation of the strategy, test orders were falling at a rate of 0.42% per fortnight (P<0.001), with an absolute reduction of 0.59% per fortnight, corresponding to a reduction of 14.5% over the 12-month study period.

Conclusion

The authors’ tailored guideline combined with educational messages reduced serum immunoglobulin test ordering in primary care over a 1-year period. Given the rarity of the conditions for which the test is utilised and the fact that the researchers had only population-level data, further investigation is required to examine the clinical implications of this change in test-ordering patterns.
Extensão Universitária e Formação de Professores: um intercâmbio enriquecedor de conhecimento entre escola e universidade
Authors: Veiga Mariana Souza , Azevedo Barbara , Belli Isadora , Sousa Fernanda
Published: October 2019

O presente trabalho tem como objetivo discutir a importância das atividades de extensão universitária e sua contribuição para a formação docente. Buscamos demonstrar como ela promove possibilidades para a imersão de professores em formação em ambiente escolar, ao promover a aproximação entre a comunidade eacademia e proporcionar experiências transformadoras para todos os envolvidos. Paraisso, apresentaremos algumas atividades realizadas pelo projeto de extensão “Contos de Mitologia”, da área de Estudos Clássicos da FALE/UFJF.