bluuebunny/crossref_metadata_2025 huggingface dataset:
Internacionalização e ensino de línguas estrangeiras
Authors: Souza Marina Mello de Menezes Felix de , Albuquerque-Costa Heloisa , Souza Valeska Virgínia Soares , Pereira Telma Cristina de Almeida Silva
Published: January 2025

O processo de internacionalização das Instituições de Ensino Superior (IES) brasileiras e as ações por ele desencadeadas têm sido um ponto central de discussão no âmbito das políticas e das práticas linguísticas dessas instituições. A internacionalização é um processo que tem como objetivo principal assegurar a visibilidade nacional e internacional da produção, da mobilidade acadêmica, da internacionalização em casa e do currículo nas IES num escopo mais amplo. Nesse contexto, ações que envolvem gestores, docentes e discentes em práticas de ensino, pesquisa e extensão buscam ampliar relações através de sua participação em projetos cujos desdobramentos incidem em nível local, regional, nacional e internacional. Atualmente, é importante problematizar o lugar do plurilinguismo e das diversas culturas nas políticas linguísticas educativas concernentes ao Ensino Básico e ao Ensino Superior nos documentos com foco na internacionalização elaborados pelo Ministério da Educação (MEC). Dessa forma, cientes da importância da internacionalização e das questões didático-metodológicas, socioculturais e político-linguísticas que elas suscitam para a sua concretização, nesta seção temática reunimos artigos que discutem (a) os desafios da política educacional em prol do plurilinguismo; (b) o impacto  do  processo  de  internacionalização  na  formação  de professores de línguas estrangeiras; (c) as ações políticas e didáticas de línguas e culturas com vistas à internacionalização; (d) as questões de plurilinguismo e de translinguagem; e (e) as problemáticas relacionadas aos contextos de migração.
Brasil dentro de si
Authors: Baldi Mateus Pinheiro
Published: January 2025

Este artigo pretende examinar como Caetano Veloso estruturou a canção “Triste Bahia”, presente no álbum Transa, a partir de diversos influxos – dos escritos de Gregório de Matos e do próprio Caetano ao mito sebastianista, passando pelas referências a diversas canções e à operação musical empreendida por João Gilberto. Resultado de um sofisticado procedimento de colagem, a faixa apresenta algumas das características de Transa, marcadamente a possibilidade de construção de uma ideia de Brasil durante o exílio através do que chamamos de disco-mapa.
Mário e Drummond
Authors: Pereira Carlos Speck , Candido Jeferson
Published: January 2025

Este artigo propõe a análise de dois poemas, “O trovador”, de Mário de Andrade, publicado em 1922 em Pauliceia Desvairada, e “Reportagem matinal”, poema de Carlos Drummond de Andrade, publicado em 1963, no jornal Correio da Manhã e posteriormente inserido no livro Versiprosa. As duas análises partem de preocupações que se inserem na área dos estudos literários que propõe o diálogo entre literatura e música. Ambos os poemas, cada um a seu modo, apresentam a figura do sino e propõem poeticamente um estar à escuta. Para não falar no contato e relevância dos dois poetas para o modernismo brasileiro, os poemas são postos lado a lado aqui pelo signo que os une num só artigo, haja vista a disparidade temporal em que se inserem. A partir da leitura e análise dos dois poemas percebe-se uma espécie de contágio das ressonâncias do sino na matéria poética trabalhada pelos sujeitos líricos, seja na relação simbiótica (e também conflituosa) entre o sujeito e a cidade, no caso de Mário, como nas ressonâncias sineiras no passado drummondiano que retorna, como um passado “passado a limpo”.
Travestilidade em imagens
Authors: Colaça Joyce Palha , Santos Hiago Bezerra dos
Published: January 2025

Este artigo é resultado de uma pesquisa que teve como objetivo analisar o álbum Pajubá (2017) e o documentário Bixa Travesty (2019) da multiartista Linn da Quebrada. Neste texto, direcionamos nosso olhar para o encarte do CD e para fragmentos do documentário, objetivando analisar como os discursos sobre a travestilidade e o cisheteropatriarcado perpassam as obras. Para tratar desse corpus, nos inscrevemos no campo teórico Análise do Discurso materialista (Pêcheux, 1985; Orlandi, 2020) e nos apoiamos em discussões acerca do transfeminismo (Nascimento, 2021). Em nosso gesto de leitura, entendemos as imagens como materialidade significante (Lagazzi, 2011) e as tomamos como discurso. Como resultado dessa primeira parte de análise, concluímos que os discursos das vivências de travestis se materializam nas imagens mobilizadas pela artista para compor o encarte e as cenas do documentário e retomam sentidos compartilhados socialmente, pelos quais Linn da Quebrada se diz e diz da subjetividade travesti em sua obra.
Ateneu contra Platão (Deipnosophistae, XI.504c-509e)
Authors: Novaes Julia Guerreiro de Castro Zilio
Published: January 2025

A presente tradução apresenta a “terceira polêmica” antiplatônica do Deipnosophistae, ou O Banquete dos Eruditos, de Ateneu de Naucrátis (XI.504c-509e). A introdução e as notas visam sublinhar o modo como Ateneu é um exemplo eloquente, simultaneamente, da recepção da forma dialógica platônica como modelo literário e, por outro lado, da recepção negativa do platonismo por parte dos antigos. Na síntese dessa ambivalência, não surpreende que a crítica antiplatônica não-filosófica na Antiguidade atentasse particularmente aos aspectos dramáticos e estilísticos dos diálogos.
retorno ao mito em "Atlântida, Reino Perdido" (1989)
Authors: Coelho Luana da Silva , Pereira Helena Bonito Couto
Published: January 2025

Partindo das interseções entre o passado e o presente nos estudos da literatura comparada, o presente trabalho tem por objetivo analisar a intertextualidade no miniconto infantil “Atlântida, Reino Perdido” (1989), de Rita Lee, com o clássico mito da ilha de Atlântida, retratado por Platão nos diálogos de Timeu e Crítias, escritos por volta de 360 a.C. Constituem suportes para a pesquisa bibliográfica autores como Nitrini (2000), Perrone-Moisés (2016) e Samoyault (2008) para discutir o conceito e aplicações da intertextualidade, além de Eliade (1972), Lopes (2011) e Silva et al. (2020), que discorrem sobre mito e recepção. Infere-se, então, que os usos do passado e recepção dos escritos da Antiguidade Clássica se renovam constantemente pelo movimento da intertextualidade, como ocorre no miniconto selecionado, em que se retoma a reescrita do mito de Platão em uma perspectiva lúdica.
Saberes e fazeres da Espada de Fogo: possibilidades para a Educação em Ciências na Educação Escolar Quilombola
Authors: Santos Jessica Araujo dos , Lopes Edinéia Tavares
Published: January 2025

Este artigo tem como objetivo refletir sobre a produção da Espada de Fogo como temática para a Educação em Ciências na escola da comunidade quilombola Porto d’Areia, considerando a proposta de contextualização a partir de critérios fundamentados em Paulo Freire e nas Diretrizes Curriculares Nacionais para a Educação Escolar Quilombola. A temática evidenciou as possibilidades para a contextualização na Educação em Ciências nessa comunidade, proporcionando a educação antirracista.
Language rights, indigenous cultures and intercultural education in the Brazilian and Polish contexts: approaches to additional language teaching
Authors: Figueira-Cardoso Samuel
Published: January 2025

This paper examines linguistic diversity in Brazil and Poland, focusing on the status of indigenous languages and the teaching of additional languages, such as Portuguese, under an intercultural approach (Baniwa, 2013; Kayapó, 2019). The research starts from the conception of language as a historical and social phenomenon (Marcuschi, 2008), analyzing language rights in both countries (Pisarek, 2011; Rodrigues, 2015; Maher, 2016; Szwajczuk, 2013; Przybyła-Wilkin, 2021) and reflecting on the incorporation of these languages into the educational context, with special attention to the training of Brazilian Studies students at Polish universities (Figueira-Cardoso, 2021; 2023). Based on an interpretivist qualitative analysis, anchored in a literature review and document analysis (Cellard, 2008; Lüdke; André, 2022; Paiva, 2019), the study compares the Polish and Brazilian contexts, addressing the role of indigenous and intercultural school education in building a pluri-multilingual society. The defense of an education that considers cultural and linguistic diversity is central, highlighting the urgency of curricula that respect the realities of indigenous communities and promote a transformative and inclusive education. The article concludes by suggesting the incorporation of these themes into the teaching of Portuguese as an additional language, both in Brazil and in foreign universities, with a view to strengthening interculturality and cultural sustainability.
Condições de ingresso e permanência de indígenas nas Instituições Federais de Ensino Superior entre 2013 e 2019
Authors: Meireles Everson , Santana Luciana Alaíde Alves , Carvalho José Jorge de , Nacif Paulo Gabriel Soledade
Published: January 2025

Este artigo avalia os efeitos de ações afirmativas no ingresso e permanência estudantes indígenas em cursos de graduação de Instituições Federais de Ensino Superior (IFES). Apresenta dois estudos descritivo-exploratórios e transversais, realizados a partir de microdados secundários. No Estudo 1 foi analisado o perfil de estudantes indígenas (N = 10.736) de 65 IFES, condições de acesso e permanência. No estudo 2 foram analisados os percentuais de ingresso de indígenas (N = 3.001) pela Lei de Cotas, em contraponto à proporção de indígenas na população em cada Unidade da Federação (UF). Os resultados indicaram que a Lei de Cotas impulsionou o ingresso de indígenas nas IFES, contudo, estes ainda estavam subrepresentados em 14 UF. Estudantes indígenas, aldeados/as ou não, possuem perfil mais vulnerável na comparação com os demais estudantes, demandando programas de ações afirmativas e permanência estudantil, sensíveis às suas necessidades específicas do ponto de vista material e simbólico.
A universidade é para indígena e quilombola?: reflexões sobre a atualidade da permanência no ensino superior do Brasil
Authors: Favacho Maria Fernanda Monteiro , Teti Marcela Montalvão , Santos Daniele Vasco
Published: January 2025

O presente artigo versa sobre os processos de acesso e de permanência de indígenas e quilombolas no ensino superior brasileiro. Pretende levantar reflexões sobre a complexidade envolvida na problemática da inserção dos povos tradicionais nas universidades e destacar os desafios do acesso e da permanência. Para tanto, apresenta uma breve história das políticas públicas de ações afirmativas no ensino superior e uma revisão bibliográfica acerca do processo e de sua presença nas universidades. Destaca-se que, a partir do levantamento bibliográfico realizado, foram encontrados mais trabalhos sobre indígenas na universidade que sobre quilombolas. Nota-se que a linguagem e os currículos configuram obstáculos à democratização da educação e que precisam ser superados. Por fim, defende-se que o Ensino Superior deva garantir a valorização da heterogeneidade dos modos de vida e diversas etnias brasileiras.
Development of Human Capital in the Labor Market in the Modernization of the Economy of Kazakhstan
Authors: Sabirova Rysty , Andabayeva Gulmira , Mussayeva Aiman , Bissembiyeva Zhanargul , Tazhidenova Ainur , Karimbayeva Gulzhan
Published: January 2025

Kazakhstan today is a country with a low level of economic development, although it has sufficient resources and manpower. The purpose of the study is to determine the specifics of human capital development in the labor market under the conditions of modernization of the economy of Kazakhstan. The analysis of economic indicators has shown that the financial stability of the country is at a low level. The study of the labor market has established that its labor supply is sufficient but low-promising. The perfect econometric modeling using the additive method of forecasting has shown that in the next two periods it should be expected an increase in the labor force. With the help of linear forecasting, it was established that in the next two periods of education and labor market reforms are not carried out, the economic situation of the country will continue to deteriorate.
Intercultural competence measurement tools for Indonesian students: Adaptation, testing construct validity, and measurement invariance with the MIMIC model
Authors: Arlianto Arlianto , Prahoro Alfedro Putut , Oktavia Aini
Published: January 2025

Background: Intercultural competence (IC) is a crucial ability, especially in the current context of increased social mobility and globalization. However, it's alarming that no IC instrument or measurement tool adaptation and psychometric property testing has been found in Indonesia, particularly among the student population. This absence highlights a significant gap in research that needs to be addressed.Purpose: This study aims to adapt and test the psychometric properties of an intercultural competence instrument for Indonesian students.Method: 589 students from public and private universities in Indonesia with various socio-demographic backgrounds participated by completing the Intercultural Competence Self-assessment (ICSa) and the Intercultural Effectiveness Scale (IES) that has been adopted into the Indonesian version. The data we obtained from all participants was analyzed using Confirmatory Factor Analysis (CFA) and the MIMIC models.Findings: The analysis results showed that both instruments meet the model fit index, but the data produced by IES is more susceptible to measurement invariance than ICSa.Implication: For future research, we suggest 1) exploring the dynamics of socio-demographic variables in the development of students' intercultural competence and 2) Survey studies using IC instruments that we have adapted to consider socio-demographic data as covariates when conducting statistical analysis.
Mother personality trait and maternal role adaptation of first-time mothers: Self differentiation as a mediator
Authors: Muthi'ah Adisty Ghaisani , Halim Magdalena S.
Published: January 2025

Background: Mothers, especially first-time mothers, are expected by society to suitably adapt to their new role so they can nurture their children properly. Mother's self-differentiation examines their capacity to discern themselves to others and how it will help them adapt better in their transition. In this research, self-differentiation acts as a mediator between mothers' personality and their capability in maintaining their new role as a mother. Purpose: This research analyzes the mediation role of self-differentiation between personality and abilities of first-time mothers regarding their adaptation to their new role.Method: 107 participants, aged between 21 and 25 years, who have children under one year old, and an average marriage age of 1-3 years. Three measuring instruments were used, the International Personality Item Pool-Big Five Markers 50 (IPIP-BFM-50), the Differentiation of Self Scale in Two Domains (DSS-2D), and the Maternal Role Adaptation Questionnaire (MRAQ).Findings: Results indicate that aspects of mothers’ personality influence their maternal role adaptation. Furthermore, aspects of self-differentiation, significantly mediate the relationship between the mother's personality and maternal role adaptation.Implication: Mothers’ self-differentiation will support their adaption in her new role as a mother. Therefore, interventions in helping first time mothers could involve mothers' self-differentiation and personality aspects
Adaptation and validation of Social Media Use Integration Scale in Indonesian context: An exploratory and confirmatory factor analysis
Authors: Ardelia Vania
Published: January 2025

Background: The growing popularity of social media has allowed people to be able to communicate in a more efficient and effective manner, as well as sharing any information in real time. Other numerous instruments were developed to measure individuals’ social media influence in their daily lives, but these have yet remained insufficient due to solely focusing on duration. Purpose: This study aims to examine the psychometric properties of the Social Media Use Integration Scale (SMUIS) for users of the Instagram platform in the Indonesia context. The scale was originally developed by Jenkins-Guarnieri et al. (2013) to measure how individuals integrate their social media usage with their social lives and psychological state.Method: This study used a sample of 305 participants (Male = 19.7%, Female = 80.3%) aged 18-29 years old (M = 21, SD = 3.15) which collected using purposive sampling method. Psychometric properties were analyzed using Exploratory Factor Analysis and Confirmatory Factor Analysis. Results contributed preliminary evidence of a satisfactory reliability and validity of the SMUIS in the Indonesian context. Implication: Further study should focus on testing the SMUIS on different age contexts and other social media platforms such as TikTok.
The role of transformational leadership on innovative work behavior: A moderated-mediation study
Authors: Az Zahra Afifah Chusna , Etikariena Arum
Published: January 2025

Background: Innovative work behavior is crucial in enhancing governmental organizations' efforts to community services. Innovation among employees could be enhanced by transformational leadership that fosters a sense of meaningful work. However, the effectiveness may be moderated by the power distance culture within the organization.Purpose: This study explores the relationship of transformational leadership and innovative work behavior through mediator and moderator mechanisms.Method: 125 civil servants at government organizations X and Y in Indonesia participated by completing Innovative Work Behavior Scale (α = .96), Multifactor Leadership Questionnaire (α = .96), The Work and Meaning Inventory (α = .86), and the Power Distance Scale (α = .84) distributed online. Moderated mediation effects were analyzed using PROCESS.Findings: Analysis showed that transformational leadership was not related to innovative work behavior, but meaningful work was found to mediate the influence of transformational leadership on innovative work behavior (β = 0.217, SE = 0.079, 95% CI [0.069, 0.382]). However, power distance culture did not moderate these relationships directly or indirectly.Implication: This study provides empirical evidence regarding the role of transformational leadership on employee innovative work behavior and the role of individual and group-level variables. The findings also underscore the importance of meaningful work design to improve employee innovative work behavior.
Postoperative Microscopic Pyuria and Role of Damage-Associated Molecular Pattern: A Literature Review
Authors: Kim Min-Kyu , Kim Ki Hong
Published: January 2025

All patients who undergo transurethral prostate surgery exhibit pyuria and microscopic hematuria in postoperative urinalysis. Postoperative asymptomatic pyuria is associated with the inflammatory process and surface remodeling of the prostate, rather than infection. Various studies have investigated the incidence, duration, and risk factors for postoperative pyuria, noting that factors like age, surgery time, and prostate size can influence outcomes. Postoperative pyuria reflects tissue recovery and inflammation, and the use of antibiotics in asymptomatic patients may not be appropriate.
Submicron quantum dot light-emitting diodes enabled by pixelated topological meta-mirror
Authors: Ye Taikang , Tian Dadi , Wu Dan , Sun Xiao Wei , Wang Kai
Published: January 2025

As a highly competitive display technology, the realization of pixelated full color quantum dot light emitting diodes (QLEDs) is an indispensable step for high resolution display. Meanwhile, with the rise of near eye display, a submicron pixel size is required for a high-resolution display within a small area less than 1 inch. However, the realization of submicron full color quantum dot pixels by direct patterning is still a big challenge. In this work, we propose a topological meta-mirror structure for the realization of submicron RGB QLEDs. The pixelated topological meta-mirror is introduced with a sufficient design freedom. A powerful light manipulation capability is offered by the topological meta-mirror even with limited period number, which enables the construction of RGB meta-cavities. The pure RGB emissions from meta-cavities can be realized with energy ratios larger than 88 % based on optimized topological meta-mirrors. For a subpixel size of 1 μm, the energy ratios for target color emission can still be larger than 85 %, which indicates a pure color emission. And a minimum subpixel size of 0.6 μm and an ultra-high pixel density of 21,666 pixel per inch can be realized with a 3 × 3 topological meta-mirror array. The proposed meta-cavity structure based on topological meta-mirror provides a new technique route for full color QLEDs especially for high pixel density required scenarios.
The crystal structure of 4–bromo-3,5-dinitropyrazole
Authors: Xiaolei Wang , Xianping Xin , Fanfan Sheng , Linxiu Zhao , Duanlin Cao , Fude Ren
Published: January 2025

C3HBrN4O4, monoclinic, P21/c (no. 14), a = 11.9791(4) Å, b = 5.9291(2) Å, c = 9.8188(4) Å, β = 96.520(1)∘, V = 692.87(4) Å3, Z = 4, R

gt
(F) = 0.0291, wR

ref
(F
2) = 0.0676, T = 170 K.
Crystal structure of bis ((1-((E)-((4-methoxyphenyl)imino)methyl)naphthalen-2-yl)oxy) copper(II), C36H28CuN2O4
Authors: Abbas Haneen Fadhil , Saleh Basil A. , Al-Doghachi Faris A. J. , Kariuki Benson M. , El-Hiti Gamal A.
Published: January 2025

C36H28CuN2O4, tetragonal, P4̄21
c (no. 114), a = 18.9249(5) Å, c = 7.9571(5) Å, V = 2,849.9(2) Å3, Z = 4, R
gt(F) = 0.0538, wR
ref(F
2) = 0.1336, T = 293 K.
Quantitative analysis and modeling of ride sharing behavior based on internet of vehicles
Authors: Cai Liang
Published: January 2025

As an important measure of traffic demand management, ride sharing can effectively increase the number of passengers from private car and bicycle, reduce vehicle travel rates, and thus alleviate traffic congestion and air pollution. With the rapid development of the internet of vehicles technology, the systematic study of private car sharing behavior and key technologies of sharing systems, and the construction of a road network spatiotemporal resource dynamic optimization theory and method guided by sharing priority in the internet of vehicles environment is a research work with great theoretical and practical values. This study investigates the ride sharing behavior and the influencing factors, such as education background, occupation, time and cost, and so on, based on internet of vehicles. Meanwhile, a Game-theory-based model was proposed and the local stability at equilibrium point was quantitatively studied. Private car sharing travel is influenced by various factors such as policies, technology, and system efficiency. Only by coordinating the operation of multiple factors can its effectiveness be fully utilized, and traffic congestion can be truly alleviated.
Optimization of sustainable corn–cattle integration in Gorontalo Province using goal programming
Authors: Imran Supriyo , Indriani Ria , Hippy Mohammad Zubair
Published: January 2025

Farmers cannot achieve the optimum profits using an integrated system in corn and cattle farming because they are not utilizing their resources in the best way possible. Therefore, finding better ways to use farm waste as animal food and cow manure as corn plant fertilizer is of utter importance. Goal programming enables a combination of production because it can complete several goals simultaneously. To the best of our knowledge, this type of analysis has not been used in previous livestock crop integration studies. Our study aims to (1) determine the optimal production combination in corn–cattle integration and (2) analyze the optimal allocation of resource use in corn–cattle integration. A total of 66 corn–cattle farmers were interviewed for this study. Data were analyzed through a goal programming model using Linear Interactive and Discrete Optimizer. The results indicate that (1) the optimal production combination with profit targets, production costs, and production risks in corn–cattle integration is met, but the achievement value obtained is still below the target, where the best optimal production combination is 14,693 kg of corn, 18 cows, 3,061 kg of corn waste, and 6,087 kg of compost. (2) In the corn–cattle integration system, the best way to use resources is to increase the supply of medicine, land, and labor by one unit. This is true even if those resources are scarce. The sensitivity interval for the optimal use of production resources in the corn–cattle integration system with the target of profit, cost, and production risk can be increased by 1% from the amount of resources used to infinity and can be reduced by 4–16% of the amount of resources used. To be more food secure, independent, wealthy, and able to support ecosystem sustainability in rural areas, farmers should set up an integrated corn–cattle system with the right mix of output and resource allocation.
Bertrand Russell’s Doxastic Sentimentalism (and Neutral Monism)
Authors: Hickerson Ryan
Published: January 2025

This paper reinterprets doxastic sentimentalism and neutral monism, as these doctrines appear in Bertrand Russell’s “On Propositions” (1919) and The Analysis of Mind (1921). It argues that Russell’s theory of belief, in this particular period, posited at least seven distinct types of feeling, but only one type of entity. The paper’s principal thesis is that Russell treated believing as feelings, but it also draws the conclusions that monism and sentimentalism are logically independent of one another, and that sentimentalism and (at least one type of) behaviorism are inconsistent, qua theories of belief.
The Late Bronze Age harbour of Pefkakia: evidence from transport containers suggests site's role
Authors: Lis Bartłomiej , Batziou Anthi
Published: January 2025

Numerous transport stirrup jars have been found at the site of Pefkakia. Most were manufactured in Crete with some from the Greek mainland. There were also at least two Canaanite jars from the Carmel coast. These finds and the first results of petrographic analysis attest to the site's role as a major Aegean harbour.
Decoding the WHO Global Tuberculosis Report 2024: A Critical Analysis of Global and Chinese Key Data
Authors: Chen Zhi , Wang Tao , Du Jingli , Sun Lin , Wang Guirong , Ni Ruizi , An Yajing , Fan Xueting , Li Yufeng , Guo Rui , Mao Lirong , Jing Wei , Shi Ke , Cheng Jing , Wang Qinglan , Nie Wenjuan , Liu Haican , Liang Jianqin , Gong Wenping
Published: January 2025

The World Health Organization (WHO) “Global Tuberculosis Report 2024” underscores the ongoing challenges and progress in the global fight against tuberculosis (TB). Despite a slowdown in the annual increase in TB cases and a decline in TB-related deaths, the disease remains a significant public health threat with 10.8 million new cases reported in 2023. The report reveals a persistently high burden of TB, especially in low- and middle-income countries, and highlights the escalating issue of drug-resistant TB. The report also emphasizes the critical need for increased funding, improved diagnostics, and more effective TB treatment regimens. The impact of the COVID-19 pandemic on TB control has been substantial, disrupting healthcare services and exacerbating existing challenges. This paper provides an in-depth interpretation of the report, analyzes global TB trends, updates the status of drug-resistant TB, discusses the intersection between TB and HIV, and summarizes the implications of the pandemic on TB control efforts. The report concludes with a call for intensified global action, including increased investment in research and innovation, to achieve the United Nations’ Sustainable Development Goals related to TB control. The stakes are high, but with concerted efforts, the goal of ending the TB epidemic is within reach.
Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome
Authors: Streckwall Lucas , Martini Nancy , Sedlinsky Claudia , Schurman León , Gangoiti María Virginia , McCarthy Antonio Desmond
Published: January 2025

Metabolic syndrome (MetS) is associated with osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and accumulation of arterial calcifications (ACs). Metformin (MET) inhibits this transdifferentiation in vitro. Here, we evaluate the in vivo efficacy of oral MET to reduce AC in a model of MetS. Twenty young male Wistar rats were divided into two groups: one received water and the other received water plus 20% fructose to induce MetS. After 14 days, and for another 4 weeks, MET (100 mg/kg per day) was added to half of each group’s drinking source, thus C (water), F (fructose), M (MET) and FM (fructose + MET). Serum and adipose tissue were collected. Aortas were dissected for histomorphometric and immunohistochemical analysis, ex vivo calcification studies and isolation of VSMCs to measure their alkaline phosphatase activity (ALP), collagen production, extracellular mineralization, gene expression of RUNX2 and receptor for advanced glycation end-products (AGEs) (RAGE), and elastic fiber production. F group showed parameters compatible with MetS. Aortic tunica media from F showed decreased elastic-to-muscular layer ratio, increased collagen content and increased levels of the AGEs structure carboxymethyl-lysine. Aortic arches from F presented a tendency for higher ex vivo calcification. VSMCs from F showed increased ALP, collagen secretion, mineralization and expression of RUNX2 and RAGE, and decreased elastic fiber production. All these effects were reverted by MET cotreatment (FM group). In vitro, AGEs-modified bovine serum albumin upregulated RAGE expression of control VSMCs, and this was prevented by MET in an AMP kinase-dependent manner. Thus, experimental MetS induces RAGE upregulation and osteogenic transdifferentiation of aortic VSMCs curbed by oral treatment with MET.
Immunolocalization of SP22 (Park7) on the human sperm membrane is indicative of live birth
Authors: Klinefelter Gary R , Diamond Michael P , Krawetz Stephen A
Published: January 2025

With the decline in sperm quality over the recent decades, there is little doubt that the decreased efficiency of spermatogenesis in men reflects their increasing susceptibility to environmental and pharmaceutical exposures that can compromise male fecundity. More than twenty years have passed since we discovered a novel sperm membrane protein (SP22) derived from the Park7 gene that is highly correlated with the fertility of rat sperm exposed to epididymal toxicants. We subsequently discovered that SP22 originates in the testis and is also compromised during exposure to testicular toxicants. Recently, we were given an opportunity to test the hypothesis that human sperm may also have reduced fertility when levels of SP22 are significantly decreased. Using a recombinant antibody to the functional epitope of SP22, we compared sperm from donors who achieved a live birth to donors who were not able to achieve a pregnancy. Sperm SP22 was significantly reduced in a group of donors not able to achieve a pregnancy. A similar reduction in birth was also observed among specific Park7 and SP22 exons when a group of donors unable to achieve a pregnancy was compared to the live birth donors. To our knowledge, this is the first demonstration that SP22 expression can be compromised in men with reduced fertility. This opens the door to incorporating SP22 analyses in future epidemiology studies and developing over-the-counter testing for men with suspected male infertility.

Lay summary

Epidemiological studies suggest that sperm quality in men has been declining; however, no biomarkers of fertility were measured in these studies. We discovered a protein (SP22) that was highly correlated with fertility of sperm following toxicant exposures. We sought to evaluate the expression of this protein in men with differing fertility status. Using an antibody to SP22, we compared sperm from donors who achieved a live birth to those who were not able to achieve a pregnancy. This is the first demonstration that SP22 expression, or any sperm membrane protein, is compromised in a random group of men with reduced fertility and provides an opportunity to quantify the expression of SP22 in future epidemiology studies. We also believe that smart phone technology can now be expanded to quantify SP22 in a man’s sperm. This will enable a couple to make more informed decisions about appropriate assisted reproductive procedures.
МАКРО- И МИКРОМОРФОЛОГИЯ ПЛОДОВ НЕКОТОРЫХ ВИДОВ РОДА GERANIUM (GERANIACEAE)
Authors: ТРОШКИНА В.И.
Published: January 2025

В статье представлены результаты макро- и микроморфологического исследования плодов 41 таксона (40 видов и двух разновидностей) рода Geranium L. из трех подродов и 12 секций. Исследованы форма, размеры, поверхность перикарпия, особенности строения клеток экзокарпия. Для видов G. laetum Ledeb., G. pseudosibiricum J. Mayer, G. asiaticum Serg., G. albiflorum Ledeb., G. malyschevii Troshkina, G. affine Ledeb., G. sergievskajae (Peschkova) Troshkina, G. transbaicalicum Serg., G. turczaninovii (Serg.) Troshkina, G. popovii (Tzvelev) Tzvelev признаки строения плода изучены с помощью СЭМ впервые. Вид G. rotundifoliumпредварительно исключен из секции Batrachioides и, соответственно, подрода Robertium и перенесен в секцию Geranium подрода Geranium . Показано, что морфологию плода и механизм его вскрывания можно использовать для разделения таксонов на уровне рода и подрода; форму мерикарпия, особенности скульптуры поверхности перикарпия - на уровне секции, подсекции и вида.

The article presents the results of macro- and micromorphological study of fruits of 41 taxa (40 species and two varieties) of the genus Geranium L. from three subgenera and 12 sections. The shape, size, surface of the pericarp, and structural features of the exocarp cells were studied. For the species G. laetum Ledeb., G. pseudosibiricum J. Mayer, G. asiaticum Serg., G. albiflorum Ledeb., G. malyschevii Troshkina, G. affine Ledeb., G. sergievskajae (Peschkova) Troshkina, G. transbaicalicum Serg., G. turczaninovii (Serg.) Troshkina, G. popovii (Tzvelev) Tzvelev, the structural features of the fruit were studied using SEM for the first time. The species G. rotundifolium is preliminarily excluded from the section Batrachioides and, accordingly, the subgenus Robertium and transferred to the section Geranium of the subgenus Geranium. It is shown that the morphology of the fruit and the mechanism of its dehiscence can be used to separate taxa at the level of genus and subgenus; the shape of the mericarp, the features of the sculpture of the pericarp surface - at the level of section, subsection and species.
ФУНДАМЕНТАЛЬНЫЙ ТРУД ПО ЛЕСОВЕДЕНИЮ И ГОРНОМУ ЛЕСОВОДСТВУ
Authors: ОНУЧИН А.А. , ПАВЛОВ И.Н. , ПИМЕНОВ А.В.
Published: January 2025

Представлен обзор книги С. М. Бебия «Леса Абхазии». Монография. Сухум: Академия, 2022. 589 с.

The review is written for the book of Sergei Mikhailovich Bebiya «Forests of Abkhazia». Monograph. Sukhum: Academy, 2022. 589 p. (in Russian with English title, summary and contents).
Between Technological Innovation and Pagan Tradition: The Representation of Lithuania in Contemporary German Travel Literature
Authors: Burov Aleksej , Kotovičius Tomas Vytautas
Published: January 2025

This article explores Lithuania’s hetero-image as it is created in contemporary German travel literature. The scope of the research primarily covers three German travelogues which detail the authors’ experience during their travels in Lithuania: Drei Baltische Wege (Lucius von, 2011), Wo die Ostsee Westsee heißt (Bünz, 2018) and Gebrauchsanweisung für das Baltikum (Herre, 2014). A further source also contributes to the given analysis: The Strategy for the Presentation of Lithuania abroad 2020–2030, compiled by the Lithuanian government in 2020, and the brief communicative messages conveyed in the document, which revolve around several particulars of Lithuania’s image: economy, culture, history, science and geographic location. These messages mirror Lithuania’s auto image and present the main assessment categories chosen for analyzing the German travelogues. The article concludes that the four most widely covered aspects of economy, culture, history and science, on the one hand, convey an image of a country known for its technological advancement, cultural impact and historical significance. On the other hand, however, they portray an economically underdeveloped and politically unstable country with a generally disgruntled population. Lithuania’s geographic location is tied not to Eastern or Northern Europe, but rather to Central Europe.
The Social Dimension of Resilience: National Approaches and EU Policy (a Comparative Legal Study)
Authors: VOLODYMYR USTIMENKO
Published: January 2025

The aim of the article is to identify legal vulnerabilities at various levels of Ukraine’s legal system, assess the degree of their negative impact on the formation and implementation of the state’s social policy, and propose methods for their elimination and ways to minimize their negative effects, taking into account the achievements of the EU legal system in the studied area of relations. To achieve this research objective, general scientific and special methods of scientific inquiry were employed, including dialectical, legal hermeneutics, comparative legal, analytical-synthetic, formal-logical, system-structural analysis, and prognostic methods. The empirical basis of the research comprised the Constitution of Ukraine and other national legislative acts, selected international legal acts, EU law acts, case law of the European Court of Human Rights, specific draft laws, and analytical materials prepared by the European Committee of Social Rights, the European Commission, and others. The conclusion is substantiated that a formal approach to assessing the applicability of EU law to the regulation of specific groups of social and labor relations at the national level, and the consequent formulation of erroneous conclusions regarding the lack of need for approximation of the relevant elements of Ukraine’s legislation to EU law, creates conditions for embedding vulnerabilities in the system of legal regulation of the socio-labor sphere. If not timely identified and addressed at the appropriate stage of the legal regulation mechanism, these vulnerabilities can transform into threats to national security, a recognized component of which is the socio-economic sphere, and they will ultimately impact Ukraine’s national resilience and its social component.

Three levels of the state’s legal system have been identified, at each of which legal vulnerabilities (conflicts, gaps, flawed legal concepts, non-compliance with legislative procedures, etc.) are formed due to coordinated actions and/or inactions, as well as decisions made by authorized government bodies. These vulnerabilities can transform into hybrid threats, negatively affecting the social security system. Legal vulnerabilities have been identified at each of the three levels of the state’s legal system (legislative, implementation, and constitutional review levels), and methods for their elimination and ways to minimize their negative impacts have been proposed, taking into account the achievements of the EU legal system in the field of ensuring the formation and implementation of social and employment policies on the basis of resilience.
Governance in the Conditions of Forming a Resilient Society
Authors: SERHII ROMANIUK
Published: January 2025

The article is devoted to the consideration of the use of governance in the formation of resilience in various spheres of social life. The relevance of the work is due to the need to find institutionalized mechanisms for making mutually agreed and coordinated decisions by various actors to ensure different types of resilience. The purpose of the article is the theoretical justification of the use of various regimes of governance in the formation of resilience of various social spheres. The novelty of the article lies in the justification of the application of this management approach in ensuring resilience, adaptability and/or transformation in the restoration of the functioning of the components of society in the conditions of disasters and after their conclusion. The research methodology is based on the use of an interdisciplinary approach when considering the essential characteristics of governance. The formation of resilience is considered, in particular in the demographic, ecological spheres, state finances, labor market, improving the quality of life of the population, the development of hromadas and territories with the participation of various actors at the supranational, national, regional, local levels, as well as within households (individual level).

It was found out, firstly, that different types of resilience require different regimes of governance: in real circumstances, all regimes are not applied in their “pure form”, but form certain clusters of governance approaches. Secondly, the potential benefits of governance in the formation of various types of resilience are not achieved automatically, but can be obtained, in particular, by achieving a high level of public trust in authorities, active fight against corruption, and high-quality political leadership. Based on the study of all three types of resilience, the most widespread regimes of governance with the participation of various decisionmaking actors at different territorial levels were identified. The article uses general scientific research methods: analysis, synthesis, comparison, generalization.
ВАЛЮТНА ПОЛІТИКА ТА ЇЇ ВПЛИВ НА РОЗВИТОК КОРПОРАТИВНОГО СЕКТОРУ ЕКОНОМІКИ УКРАЇНИ
Authors: ГАРКАВЕНКО Валентина , ЄРШОВА Галина
Published: January 2025

Досліджено валютну політику держави, зокрема, такі її складові, як валютно-курсова політика і валютні обмеження, визначено вплив її змін на діяльність корпоративного сектору економіки України. Зроблено висновок, що не узгоджена з іншими цілями економічного розвитку країни трансформація валютної політики останнього десятиріччя, а саме валютна лібералізація, стала каталізатором формування в Україні спекулятивної фінансової моделі, оскільки сприяла насиченню фінансового ринку спекулятивним капіталом, у тому числі нерезидентів, максимізації їх прибутків з одночасною можливістю легкого виведення капіталу з України.
Доведено, що коливання валютного курсу впливає на всіх суб’єктів господарювання, а його інтенсивність залежить від каналу трансмісії. Зокрема, підприємства, що здійснюють зовнішньоекономічну діяльність, відчувають швидкий і безпосередній вплив зміни валютного курсу, проте внутрішньоорієнтовані підприємства, у свою чергу, відчувають його за рахунок інтенсифікації інфляційних процесів. Зроблено висновок, що в умовах курсової нестабільності, невизначеності й непослідовності політики Національного банку України застосування необґрунтованих обмежувальних заходів призводить до валютної «стерилізації» бізнесу, особливо експорто- та імпортоорієнтованого, стимулює появу «сірих схем», зростання тіньового сектору в економіці.
Обґрунтовано, що за відсутності об’єктивних чинників ревальвації курсу національної валюти доцільною є повільна помірна девальвація шляхом установлення режиму «повзучої прив’язки», а не гнучке курсоутворення. Такий підхід виглядає виправданим у контексті недопущення реальної ревальвації гривні, зменшення втрат міжнародних резервів, уникнення таких негативних наслідків, як гальмування внутрішнього виробництва за каналами скорочення експорту і нарощування імпорту, а також запровадження принципів передбачуваності й прогнозованості валютного курсу.
ІНСТРУМЕНТИ СМАРТ-ЕКОНОМІКИ: ТЕОРЕТИЧНИЙ І ПРАКТИЧНИЙ ПІДХОДИ
Authors: ПОПАДИНЕЦЬ Назарій , ОЛЕКСЮК Ганна
Published: January 2025

Досліджено основні засади формування і розвитку смарт-економіки як комплексної екосистеми, у якій врівноважуються економічна, соціальна, екологічна складові. З позиції стратегічного розвитку територій і регіонів розкрито значення кожного смарт-елементу, а саме конкретика, вимірність, досяжність, значущість і обмеженість у часі. Розроблено комплекс інструментів смарт-економіки, обґрунтовано їх характеристики й ознаки, які доцільно використати при розробленні стратегічних планів соціально-економічного розвитку регіонів і територіальних громад, управління ними. Запропоновано модель формування елементів смарт-економіки. Обґрунтовано концепцію смарт-економіки як комплексної екосистеми, що об’єднує економічні, екологічні, соціальні та інші складові. Розглянуто системний підхід до управління розвитком смарт-економіки через оптимальне інтегрування її елементів. Акцентовано на необхідності проведення комплексних системних досліджень для вивчення екосистем смарт-економіки. Підкреслено, що підприємницькі екосистеми потребують географічного визначення і взаємодії з секторами і галузями. Описано екосистемний підхід як основу для принципів системного розвитку і еволюційного зростання. Основні елементи SMART виокремлено як критерії для досягнення цілей у смарт-економіці. Запропоновано використання комплексного підходу при формуванні стратегічних планів розвитку на рівні громад, регіонів і держави, з акцентуванням на інноваційні ресурси і смарт-економічні інструменти, які сприятимуть збалансованому й всеосяжному розвитку суспільства. Наголошено на необхідності подальшого вивчення глобального досвіду і впровадження інструментів смарт-економіки в соціально-економічний розвиток України на прикладі практичного підходу щодо їх використання на регіональному рівні.
An ultra-fast validated green UPLC-MS/MS method for the quantification of osimertinib in human liver microsomes: Screening for ADME parameters and in vitro metabolic stability
Authors: Attwa Mohamed W. , Abdelhameed Ali S. , Kadi Adnan A.
Published: January 2025

Osimertinib (Tagrisso, AstraZeneca Pharmaceuticals) is the inaugural third-generation irreversible EGFR-TKI that specifically targets both the EGFR T790M resistant mutation and EGFR-TKI-sensitizing mutations. On September 25, 2024, the Food and Drug Administration authorized osimertinib (OSM) for adult patients with locally advanced, unresectable (stage III) non-small cell lung cancer (NSCLC). The target of this work was to establish a fast, accurate, environmentally friendly, and highly sensitive UPLC-MS/MS methodology for detecting OSM levels in human liver microsomes (HLMs). The separation of OSM and zanubrutinib (ZNB) was accomplished utilizing a C8 column and an isocratic mobile phase. The linearity of the OSM calibration curve spanned from 1 to 3,000 ng mL−1. The AGREE score of 0.76 validates the efficacy of the current approach. The brief in vitro half-life (23.72 min) and moderate intrinsic clearance (34.18 mL min−1 kg−1) of OSM indicate that it resembles drugs with a moderate extraction ratio. The present LC-MS/MS technique is regarded as the primary analytical methodology for quantifying OSM in HLM matrices. The characterization of OSM metabolic stability and in silico ADME features are crucial for progressing the discovery of novel drugs with improved metabolic stability.
Modern Islamic Eco-Religion
Authors: Shefer-Mossensohn Miri
Published: January 2025

Since Lynn White Jr., an extensive and rich body of literature has emerged, focusing on the intersection of environmental ethics and sustainability education, particularly examining the potential contribution of ecotheology in fostering ecological restoration. This article ventures into the Islamic case, surveying key positions from the 1960s through the early twenty-first century, in English, Arabic, and Turkish. It elucidates the historical contexts that shaped this discursive reality, underscoring intellectual, religious, and sociopolitical trends. The study probes the manifestations of Islamic echotheology within a focal region of the Islamic world—the Middle East—while explicating its connections to global trends. The article further suggests that these circumstances may account for the discrepancy between the robust discursive reality and the relative modest impact of Muslim values and faith-based Muslim actors on local, regional, and global sustainable actions. The deliberate use of ‘ecotheology’ aims to facilitate a dialogical engagement with other world religions.