bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers
Authors: Sulaiman Sarah , Gershkovich Pavel , Hoad Caroline L. , Calladine Matthew , Spiller Robin C. , Stolnik Snow , Marciani Luca
Published: January 2022

Oral specially coated formulations have the potential to improve treatment outcomes of a range of diseases in distal intestinal tract whilst limiting systemic drug absorption and adverse effects. Their development is challenging, partly because of limited knowledge of the physiological and pathological distal gastrointestinal factors, including colonic chyme fluid distribution and motor function. Recently, non-invasive techniques such as magnetic resonance imaging (MRI) have started to provide novel important insights. In this feasibility study, we formulated a coated capsule consisting of a hydroxypropyl methylcellulose (HPMC) shell, coated with a synthetic polymer based on polymethacrylate-based copolymer (Eudragit®) that can withstand the upper gastrointestinal tract conditions. The capsule was filled with olive oil as MRI-visible marker fluid. This allowed us to test the ability of MRI to track such a coated capsule in the gastrointestinal tract and to assess whether it is possible to image its loss of integrity by exploiting the ability of MRI to image fat and water separately and in combination. Ten healthy participants were administered capsules with varying amounts of coating and underwent MRI imaging of the gastrointestinal tract at 45 min intervals. The results indicate that it is feasible to track the capsules present in the gastrointestinal tract at different locations, as they were detected in all 10 participants. By the 360 min endpoint of the study, in nine participants the capsules were imaged in the small bowel, in eight participants in the terminal ileum, and in four in the colon. Loss of capsule integrity was observed in eight participants, occurring predominantly in distal intestinal regions. The data indicate that the described approach could be applied to assess performance of oral formulations in undisturbed distal gastrointestinal regions, without the need for ionizing radiation or contrast agents.
Simultaneous Delivery of Econazole, Terbinafine and Amorolfine with Improved Cutaneous Bioavailability: A Novel Micelle-Based Antifungal “Tri-Therapy”
Authors: Gou Si , Monod Michel , Salomon Denis , Kalia Yogeshvar N.
Published: January 2022

Lack of accurate diagnosis and the use of formulations designed to address the poor aqueous solubility of antifungal agents, but not optimized for delivery, contribute to unsatisfactory outcomes for topical treatment of cutaneous mycoses. The objective of this study was to develop a micelle-based antifungal formulation containing econazole (ECZ), terbinafine (TBF) and amorolfine (AMF) using D-α-tocopheryl polyethylene glycol succinate (TPGS) for simultaneous cutaneous delivery of three agents with complementary mechanisms of action. The antifungal “tri-therapy” micelle-based formulation containing 0.1% ECZ, 0.1% TBF and 0.025% AMF had a drug loading 10-fold lower than the “reference” marketed formulations (Pevaryl®, 1% ECZ; Lamisil®, 1% TBF; Loceryl®, 0.25% AMF). Finite dose application of the micelle-based formulation for 6 h resulted in a statistically equivalent deposition of ECZ (p > 0.05) and TBF (p > 0.05) from the 2 systems, and a 2-fold higher accumulation of AMF (p = 0.017). Antifungal concentrations above MIC80 against Trichophyton rubrum were achieved in each skin layer with the “tri-therapy”, which also exhibited a preferential deposition of each antifungal agent in pilosebaceous unit (PSU)-containing biopsies as compared with PSU-free biopsies (p < 0.05). A planned clinical study will test whether these promising results translate to improved therapeutic outcomes in vivo.
Multifunctional Biomimetic Nanofibrous Scaffold Loaded with Asiaticoside for Rapid Diabetic Wound Healing
Authors: Anand Sneha , Rajinikanth Paruvathanahalli Siddalingam , Arya Dilip Kumar , Pandey Prashant , Gupta Ravi K. , Sankhwar Ruchi , Chidambaram Kumarappan
Published: January 2022

Diabetes mellitus is a chronic disease with a high mortality rate and many complications. A non-healing diabetic foot ulcer (DFU) is one the most serious complications, leading to lower-extremity amputation in 15% of diabetic patients. Nanofibers are emerging as versatile wound dressing due to their unique wound healing properties, such as a high surface area to volume ratio, porosity, and ability to maintain a moist wound environment capable of delivering sustained drug release and oxygen supply to a wound. The present study was aimed to prepare and evaluate a polyvinyl alcohol (PVA)–sodium alginate (SA)–silk fibroin (SF)-based multifunctional nanofibrous scaffold loaded with asiaticoside (AT) in diabetic rats. The SEM findings showed that fibers’ diameters ranged from 100–200 nm, and tensile strengths ranged from 12.41–16.80 MPa. The crosslinked nanofibers were sustained AT over an extended period. The MTT and scratch assay on HaCat cells confirmed low cytotoxicity and significant cell migration, respectively. Antimicrobial tests revealed an excellent anti-microbial efficacy against P. aeruginosa and S. aureus bacteria. In-vivo study demonstrated better wound healing efficacy in diabetic rats. In addition, the histopathological studies showed its ability to restore the normal structure of the skin. The present study concluded that developed multifunctional nanofibers have a great potential for diabetic wound healing applications.
Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in a Continuous Direct Compression Line
Authors: Kreiser Marius J. , Wabel Christoph , Wagner Karl G.
Published: January 2022

The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line. As all mixture components, including the lubricant (magnesium stearate), are passing simultaneously through one blender, an impact on the subsequent process steps and critical product properties, such as content uniformity and tablet tensile strength, is to be expected. A design of experiment (DoE) was performed to investigate the impact of the blender variables hold-up mass (HUM), impeller speed (IMP) and throughput (THR) on the mixing step and the subsequent continuous manufacturing process steps. Significant impacts on the mixing parameters (exit valve opening width (EV), exit valve opening width standard deviation (EV SD), torque of lower impeller (TL), torque of lower impeller SD (TL SD), HUM SD and blend potency SD), material attributes of the blend (conditioned bulk density (CBD), flow rate index (FRI) and particle size (d10 values)), tableting parameters (fill depth (FD), bottom main compression height (BCH) and ejection force (EF)) and tablet properties (tablet thickness (TT), tablet weight (TW) and tensile strength (TS)) could be found. Furthermore, relations between these process parameters were evaluated to define which process states were caused by which input variables. For example, the mixing parameters were mainly impacted by impeller speed, and material attributes, FD and TS were mainly influenced by variations in total blade passes (TBP). The current work presents a rational methodology to minimize process variability based on the main blender variables hold-up mass, impeller speed and throughput. Moreover, the results facilitated a knowledge-based optimization of the process parameters for optimum product properties.
Preparation of Ligand Brush Nanocapsules for Robust Self-Controlled Antimicrobial Activity with Low Cytotoxicity at Target pH and Humidity
Authors: Koh Eunjoo , Lee Yong Taek
Published: January 2022

This study prepared nanocapsules (NCs) with excellent self-controlled antimicrobial activity at pH 6–7 and humidity 45–100%, conditions in which most bacterial and fungal strains thrive. The nanocapsule substrate (NC@SiO2) was 676 nm in diameter, and the ligand-grafted capsule (NC@SiO2-g-MAA) was 888 nm. The large surface area and outer ligand brush of the NCs induced a rapid, self-controlled antibacterial response in the pH and humidity conditions needed for industrial and medical applications. Ligand-brush NCs containing an anionic antimicrobial drug had a rapid release effect because of the repellent electrostatic force and swelling properties of the ligand brushes. Controlled release of the drug was achieved at pH 6 and humidity of 45% and 100%. As many carboxylic acid groups are deprotonated into carboxylic acids at pH 5, the NC@SiO2-g-MAA had a high negative charge density. Carboxylic acid groups are anionized (–COO−) at pH 6 and above and push each other out of the capsule, expanding the outer shell as in a polymer brush to create the release behavior. The surface potential of the NC intermediate (NC@SiO2-MPS) was −23.45 [mV], and the potential of the capsule surface decreased to −36.4 [mV] when the MAA ligand brushes were grafted onto the surface of the capsule intermediate. In an antimicrobial experiment using Escherichia coli, a clear zone of 13–20 mm formed at pH 6, and the E. coli was eradicated completely at pH 6 and pH 7 when the humidity was 100%.
Scanning Angle Magnification with Compact Reflective Optics for Light Detection and Ranging
Authors: Mu Cheng-Ta , Chang Po-Cheng , Chen Cheng-Huan
Published: January 2022

The function of lidar requests a large scanning angle for a wide field of view and a well calibrated collimation of the laser beam for distant sensing. Besides meeting the required functionality, the compact form factor of the whole optical system is also highly desirable for the ease of being installed in mobile systems. In corresponding to the currently developed phase array laser which can achieve beam scanning without mechanical movement but still with a small scanning angle, a compact optics consisting of only two reflective surfaces has been proposed to magnify the scanning angle of a laser beam up to seven times while keeping the divergence of the laser beam smaller than 8 mrad for some short distance applications. The prototype has been prepared and evaluated with the expected performance.
Compact Wavelength Selective Crossbar Switch with Cascaded First Order Micro-Ring Resonators
Authors: P. Khope Akhilesh S. , Zhang Robert , Helkey Roger , Alferness Rod C. , Saleh Adel A. M. , Bowers John E.
Published: January 2022

We demonstrate a compact 4×4 wavelength selective switch with 50% fewer electrical signal pads as compared with our previous generation. We report loss and crosstalk for different paths of the switch. We measure median loss of 5.32 dB and worst case crosstalk of −35 dB. The microring resonators tune by more than one free spectral range, which is an improvement over our previous generation of switches. This switch can support 8 channels at 400 GHz spacing. We conclude that it is possible to drive both microring resonators with the same voltage and separate control is not required if the fabrication variation reduces in the future.
Stability of the Discrete Time-Crystalline Order in Spin-Optomechanical and Open Cavity QED Systems
Authors: Hu Zhengda , Gao Xingyu , Li Tongcang
Published: January 2022

Discrete time crystals (DTC) have been demonstrated experimentally in several different quantum systems in the past few years. Spin couplings and cavity losses have been shown to play crucial roles for realizing DTC order in open many-body systems out of equilibrium. Recently, it has been proposed that eternal and transient DTC can be present with an open Floquet setup in the thermodynamic limit and in the deep quantum regime with few qubits, respectively. In this work, we consider the effects of spin damping and spin dephasing on the DTC order in spin-optomechanical and open cavity systems in which the spins can be all-to-all coupled. In the thermodynamic limit, it is shown that the existence of dephasing can destroy the coherence of the system and finally lead the system to its trivial steady state. Without dephasing, eternal DTC is displayed in the weak damping regime, which may be destroyed by increasing the all-to-all spin coupling or the spin damping. By contrast, the all-to-all coupling is constructive to the DTC in the moderate damping regime. We also focus on a model which can be experimentally realized by a suspended hexagonal boron nitride (hBN) membrane with a few spin color centers under microwave drive and Floquet magnetic field. Signatures of transient DTC behavior are demonstrated in both weak and moderate dissipation regimes without spin dephasing. Relevant experimental parameters are also discussed for realizing transient DTC order in such an hBN optomechanical system.
A Laser Frequency Transverse Modulation Might Compensate for the Spectral Broadening Due to Large Electron Energy Spread in Thomson Sources
Authors: Petrillo Vittoria , Drebot Illya , Krafft Geoffrey , Maroli Cesare , Rossi Andrea R. , Rossetti Conti Marcello Rossetti , Ruijter Marcel , Terzić Balša
Published: January 2022

Compact laser plasma accelerators generate high-energy electron beams with increasing quality. When used in inverse Compton backscattering, however, the relatively large electron energy spread jeopardizes potential applications requiring small bandwidths. We present here a novel interaction scheme that allows us to compensate for the negative effects of the electron energy spread on the spectrum, by introducing a transverse spatial frequency modulation in the laser pulse. Such a laser chirp, together with a properly dispersed electron beam, can substantially reduce the broadening of the Compton bandwidth due to the electron energy spread. We show theoretical analysis and numerical simulations for hard X-ray Thomson sources based on laser plasma accelerators.
Effect of Accommodation on Peripheral Higher Order Aberrations
Authors: Sapkota Kishor , Gomes Jessica , Franco Sandra
Published: January 2022

Knowledge of the effect of accommodation on image quality of peripheral retina is crucial for better understanding of the visual system, but only a few studies have been carried out in this area. This study was designed to evaluate the effect of accommodation on higher order aberrations from third to sixth Zernike polynomials in central and peripheral retina up to 23° off-axis. We used a Hartmann–Shack aberrometer to measure Zernike coefficients with both accommodated and non-accommodated eyes of 15 healthy subjects. Each Zernike coefficient, total higher order aberrations, spherical aberrations and astigmatism were compared between accommodated and non-accommodated status. Additionally, aberrations in the central retina were compared with the peripheral retina. Accommodation induced significant changes in the Zernike coefficients of vertical pentafoil C5−5 and secondary vertical tetrafoil C6−4 in central retina, secondary vertical astigmatism C4−2 on 23° of temporal retina, secondary vertical tetrafoil C6−4 and tertiary vertical astigmatism C6−2 on 10° of nasal retina, secondary vertical trefoil C5−3 and secondary vertical tetrafoil C6−4 on 23° of nasal retina, and horizontal tetrafoil C44, and secondary horizontal tetrafoil C64 on 23° of inferior retina (p < 0.05). Total higher order aberration was lower in each retinal area examined with accommodation, but it was statistically significant only on 23° temporal retina and 11.5° and 23° of superior retina (p < 0.05). Spherical aberration decreased with accommodation on 23° temporal retina (p = 0.036). Astigmatism was similar in non-accommodated and accommodated eyes. Overall, accommodation affected higher order aberration (HOA) asymmetrically in different peripheral retinal areas.
Biophysical Equations and Pressure Probe Experiments to Determine Altered Growth Processes after Changes in Environment, Development, and Mutations
Authors: Ortega Joseph K. E.
Published: January 2022

Expansive growth is a culmination of many biological processes. It is fundamental to volume growth, development, morphogenesis, sensory responses, and environmental responses of plants, fungi, and algae. Expansive growth of walled cells and plant tissue can be accurately described by a set of three global biophysical equations that model the biophysical processes of water uptake, wall deformation, and turgor pressure. Importantly, these biophysical equations have been validated with the results of pressure probe experiments. Here, a systematic method (scheme) is presented that iterates between analyses with the biophysical equations and experiments conducted with the pressure probe. This iterative scheme is used to determine altered growth processes for four cases; two after changes in the environment, one after a change in development, and another after changes by mutation. It is shown that this iterative scheme can identify which biophysical processes are changed, the magnitude of the changes, and their contribution to the change in expansive growth rate. Dimensionless numbers are employed to determine the magnitude of the changes in the biophysical processes. The biological meaning and implication of the biophysical variables in the biophysical equations are discussed. Further, additional sets of global biophysical equations are presented and discussed.
Comparative Assessment of Grassland Dynamic and Its Response to Drought Based on Multi-Index in the Mongolian Plateau
Authors: Zhang Yanzhen , Wang Zhaoqi , Wang Qian , Yang Yue , Bo Yaojun , Xu Weizhou , Li Jianlong
Published: January 2022

This study applied grassland related multi-index and assessed the effects of climate change by investigating grassland responses to drought. This process was performed to study grassland vegetation dynamic accurately and evaluate the effect of drought in the Mongolian Plateau (MP). The spatial–temporal characteristics of grassland dynamic in terms of coverage (Fv), surface bareness (Fb), and net primary production (NPP) from 2000 to 2013 were explored. We implemented the maximum Pearson correlation to analyze the grassland vegetation in response to drought by using self-calibrating Palmer Drought Severity Index (scPDSI). Results show that Fv and NPP present an increasing trend (0.18 vs. 0.43). Fb showed a decreasing trend with a value of −0.16. The grassland Fv and NPP positively correlated with scPDSI, with a value of 0.12 and 0.85, respectively, and Fb was −0.08. The positive correlation between Fv and NPP accounted for 84.08%, and the positive correlation between Fv and scPDSI accounted for 93.88%. On the contrary, the area with a negative correlation between Fb and scPDSI was 57.43%. The grassland in the MP showed a recovery tendency. The increase in grassland caused by positive reaction was mainly distributed in the middle of Mongolia (MG), whereas that caused by counter response was mainly distributed in the east and west MG and northeast Inner Mongolia autonomous region of China (IM). The relevant results may provide useful information for policymakers about mitigation strategies against the inverse effects of drought on grassland and help to ease the losses caused by drought.
Genome-Wide Association Study of Healthful Flavonoids among Diverse Mandarin Accessions
Authors: Mattia Matthew R. , Du Dongliang , Yu Qibin , Kahn Tracy , Roose Mikeal , Hiraoka Yoko , Wang Yu , Munoz Patricio , Gmitter Fred G.
Published: January 2022

Mandarins have many unique flavonoids with documented health benefits and that help to prevent chronic human diseases. Flavonoids are difficult to measure and cannot be phenotyped without the use of specialized equipment; consequently, citrus breeders have not used flavonoid contents as selection criteria to develop cultivars with increased benefits for human health or increased tolerance to diseases. In this study, peel, pulp, and seed samples collected from many mandarin accessions and their hybrids were analyzed for the presence of selected flavonoids with documented human health benefits. A genome-wide association study (GWAS) was used to identify SNPs associated with biosynthesis of flavonoids in these mandarin accessions, and there were 420 significant SNPs were found to be associated with 28 compounds in peel, pulp, or seed samples. Four candidate genes involved in flavonoid biosynthesis were identified by enrichment analysis. SNPs that were found to be associated with compounds in pulp samples have the potential to be used as markers to select mandarins with improved phytonutrient content to benefit human health. Mandarin cultivars bred with increased flavonoid content may provide value to growers and consumers.
Genome-Wide Identification of Histone Modification Gene Families in the Model Legume Medicago truncatula and Their Expression Analysis in Nodules
Authors: Lopez Loredana , Perrella Giorgio , Calderini Ornella , Porceddu Andrea , Panara Francesco
Published: January 2022

Histone methylation and acetylation are key processes in the epigenetic regulation of plant growth, development, and responses to environmental stimuli. The genes encoding for the enzymes that are responsible for these chromatin post-translational modifications, referred to as histone modification genes (HMGs), have been poorly investigated in Leguminosae species, despite their importance for establishment and activity of nitrogen-fixing nodules. In silico analysis of Medicago truncatula HMGs identified 81 histone methyltransferases, 46 histone demethylases, 64 histone acetyltransferases, and 15 histone deacetylases. MtHMGs were analyzed for their structure and domain composition, and some combinations that were not yet reported in other plant species were identified. Genes have been retrieved from M. truncatula A17 and R108 genotypes as well as M. sativa CADL and Zhongmu No.1; the gene number and distribution were compared with Arabidopsis thaliana. Furthermore, by analyzing the expression data that were obtained at various developmental stages and in different zones of nitrogen-fixing nodules, we identified MtHMG loci that could be involved in nodule development and function. This work sets a reference for HMG genomic organization in legumes which will be useful for functional investigation that is aimed at elucidating HMGs involvement in nodule development and symbiotic nitrogen fixation.
Pectin–Zeolite-Based Wound Dressings with Controlled Albumin Release
Authors: Kocaaga Banu , Kurkcuoglu Ozge , Tatlier Melkon , Dinler-Doganay Gizem , Batirel Saime , Güner Fatma Seniha
Published: January 2022

Hypoalbuminemia can lead to poor and delayed wound healing, while it is also associated with acute myocardial infarction, heart failure, malignancies, and COVID-19. In elective surgery, patients with low albumin have high risks of postoperative wound complications. Here, we propose a novel cost-effective wound dressing material based on low-methoxy pectin and NaA-zeolite particles with controlled albumin release properties. We focused on both albumin adsorption and release phenomena for wounds with excess exudate. Firstly, we investigated albumin dynamics and calculated electrostatic surfaces at experimental pH values in water by using molecular dynamics methods. Then, we studied in detail pectin–zeolite hydrogels with both adsorption and diffusion into membrane methods using different pH values and albumin concentrations. To understand if uploaded albumin molecules preserved their secondary conformation in different formulations, we monitored the effect of pH and albumin concentration on the conformational changes in albumin after it was released from the hydrogels by using CD-UV spectroscopy analyses. Our results indicate that at pH 6.4, BSA-containing films preserved the protein’s folded structure while the protein was being released to the external buffer solutions. In vitro wound healing assay indicated that albumin-loaded hydrogels showed no toxic effects on the fibroblast cells.
Synthesis, Characterization and Physicochemical Properties of Biogenic Silver Nanoparticle-Encapsulated Chitosan Bionanocomposites
Authors: Ediyilyam Sreelekha , Lalitha Mahesh M. , George Bini , Shankar Sarojini Sharath , Wacławek Stanisław , Černík Miroslav , Padil Vinod Vellora Thekkae
Published: January 2022

Green bionanocomposites have garnered considerable attention and applications in the pharmaceutical and packaging industries because of their intrinsic features, such as biocompatibility and biodegradability. The work presents a novel approach towards the combined effect of glycerol, tween 80 and silver nanoparticles (AgNPs) on the physicochemical properties of lyophilized chitosan (CH) scaffolds produced via a green synthesis method.The produced bionanocomposites were characterized with the help of Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). The swelling behavior, water vapor transmission rate, moisture retention capability, degradation in Hanks solution, biodegradability in soil, mechanical strength and electrochemical performance of the composites were evaluated. The addition of additives to the CH matrix alters the physicochemical and biological functioning of the matrix. Plasticized scaffolds showed an increase in swelling degree, water vapor transmission rate and degradability in Hank’s balanced solution compared to the blank chitosan scaffolds. The addition of tween 80 made the scaffolds more porous, and changes in physicochemical properties were observed. Green-synthesized AgNPs showed intensified antioxidant and antibacterial properties. Incorporating biogenic nanoparticles into the CH matrix enhances the polymer composites’ biochemical properties and increases the demand in the medical and biological sectors. These freeze-dried chitosan-AgNPs composite scaffolds had tremendous applications, especially in biomedical fields like wound dressing, tissue engineering, bone regeneration, etc.
Improving Sustainability of the Griess Reaction by Reagent Stabilization on PDMS Membranes and ZnNPs as Reductor of Nitrates: Application to Different Water Samples
Authors: Hakobyan Lusine , Monforte-Gómez Belén , Moliner-Martínez Yolanda , Molins-Legua Carmen , Campíns-Falcó Pilar
Published: January 2022

A new approach based on the use of polydimethylsiloxane (PDMS) membranes doped with Griess reagents for in situ determination of NO2− and NO3−- in real samples is proposed. The influence of some doping compounds, on the properties of the PDMS membranes, such as tetraethyl orthosilicate (TEOS), or/and ionic liquids (OMIM PF6) has been studied. Membrane characterization was performed. To apply the procedure to NO3− determination, dispersed Zn nanoparticles (ZnNPs) were employed. The analytical responses were the absorbance or the RGB components from digital images. Good precision (RSD < 8%) and detection limit of 0.01 and 0.5 mgL−1 for NO2− and NO3−, respectively, were achieved. The approach was satisfactory when applied to the determination of NO2− and NO3− in drinking waters, irrigation and river waters, and waters from canned and fresh vegetables. The results obtained were statistically comparable with those by using nitrate ISE or UV measurement. This approach was transferred satisfactory to 96 wells for multianalysis. This study enables the improvement in the on-site determination of NO2− and NO3− in several matrices. It is a sustainable alternative over the reagent derivatizations in solution and presents several advantages such as being versatile, simplicity, low analysis time, cost, and energy efficiency. The response can be detected visually or by portable instruments such as smartphone.
Methods to Characterize Electrospun Scaffold Morphology: A Critical Review
Authors: Lopez Marquez Alex , Gareis Iván Emilio , Dias Fernando José , Gerhard Christoph , Lezcano María Florencia
Published: January 2022

Electrospun scaffolds can imitate the hierarchical structures present in the extracellular matrix, representing one of the main concerns of modern tissue engineering. They are characterized in order to evaluate their capability to support cells or to provide guidelines for reproducibility. The issues with widely used methods for morphological characterization are discussed in order to provide insight into a desirable methodology for electrospun scaffold characterization. Reported methods include imaging and physical measurements. Characterization methods harbor inherent limitations and benefits, and these are discussed and presented in a comprehensive selection matrix to provide researchers with the adequate tools and insights required to characterize their electrospun scaffolds. It is shown that imaging methods present the most benefits, with drawbacks being limited to required costs and expertise. By making use of more appropriate characterization, researchers will avoid measurements that do not represent their scaffolds and perhaps might discover that they can extract more characteristics from their scaffold at no further cost.
Fibre-Reinforced Polymer Reinforced Concrete Members under Elevated Temperatures: A Review on Structural Performance
Authors: Sharifianjazi Fariborz , Zeydi Parham , Bazli Milad , Esmaeilkhanian Amirhossein , Rahmani Roozbeh , Bazli Leila , Khaksar Samad
Published: January 2022

Several experimental and numerical studies have been conducted to address the structural performance of FRP-reinforced/strengthened concrete structures under and after exposure to elevated temperatures. The present paper reviews over 100 research studies focused on the structural responses of different FRP-reinforced/strengthened concrete structures after exposure to elevated temperatures, ranging from ambient temperatures to flame. Different structural systems were considered, including FRP laminate bonded to concrete, FRP-reinforced concrete, FRP-wrapped concrete, and concrete-filled FRP tubes. According to the reported data, it is generally accepted that, in the case of insignificant resin in the post curing process, as the temperature increases, the ultimate strength, bond strength, and structure stiffness reduce, especially when the glass transition temperature Tg of the resin is approached and exceeded. However, in the case of post curing, resin appears to preserve its mechanical properties at high temperatures, which results in the appropriate structural performance of FRP-reinforced/strengthened members at high temperatures that are below the resin decomposition temperature Td. Given the research gaps, recommendations for future studies have been presented. The discussions, findings, and comparisons presented in this review paper will help designers and researchers to better understand the performance of concrete structures that are reinforced/strengthened with FRPs under elevated temperatures and consider appropriate approaches when designing such structures.
Acknowledgment to Reviewers of Polymers in 2021
Authors:   Polymers Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Pure Chitosan-Based Fibers Manufactured by a Wet Spinning Lab-Scale Process Using Ionic Liquids
Authors: Kuznik Irina , Kruppke Iris , Cherif Chokri
Published: January 2022

Ionic liquids offer alternative methods for the sustainable processing of natural biopolymers like chitosan. The ionic liquid 1-butyl-3-methylimidazolium acetate (BmimOAc) was successfully used for manufacturing of pure chitosan-based monofilaments by a wet spinning process at lab-scale. Commercial chitosan with 90% deacetylation degree was used for the preparation of spinning dopes with solids content of 4–8 wt.%. Rheology tests were carried out for the characterization of the viscometric properties. BmimOAc was used as a solvent and deionized water as coagulation and washing medium. Optical (scanning electron microscope (SEM), light microscope) and textile physical tests were used for the evaluation of the morphological and mechanical characteristics. The manufactured chitosan monofilaments a homogeneous structure with a diameter of ~150 μm and ~30 tex yarn count. The mechanical tests show tensile strengths of 8 cN/tex at Young’s modulus up to 4.5 GPa. This work represents a principal study for the manufacturing of pure chitosan fibers from ionic liquids and provides basic knowledge for the development of a wet spinning process.
Improvement of Gas Barrier Properties for Biodegradable Poly(butylene adipate-co-terephthalate) Nanocomposites with MXene Nanosheets via Biaxial Stretching
Authors: Wang Xionggang , Li Xia , Cui Lingna , Liu Yuejun , Fan Shuhong
Published: January 2022

In order to ease the white pollution problem, biodegradable packaging materials are highly demanded. In this work, the biodegradable poly (butylene adipate-co-terephthalate)/MXene (PBAT/Ti3C2TX) composite casting films were fabricated by melt mixing. Then, the obtained PBAT/Ti3C2TX composite casting films were biaxially stretched at different stretching ratios so as to reduce the water vapor permeability rate (WVPR) and oxygen transmission rate (OTR). It was expected that the combination of Ti3C2TX nanosheets and biaxial stretching could improve the water vapor and oxygen barrier performance of PBAT films. The scanning electron microscope (SEM) observation showed that the Ti3C2TX nanosheets had good compatibility with the PBAT matrix. The presence of Ti3C2TX acted as a nucleating agent to promote the crystallinity when the content was lower than 2 wt%. The mechanical tests showed that the incorporation of 1.0 wt% Ti3C2TX improved the tensile stress, elongation at break, and Young’s modulus of the PBAT/Ti3C2TX nanocomposite simultaneously, as compared with those of pure PBAT. The mechanical dynamical tests showed that the presence of Ti3C2TX significantly improved the storage modulus of the PBAT nanocomposite in a glassy state. Compared with pure PBAT, PBAT-1.0 with 1.0 wt% Ti3C2TX exhibited the lowest OTR of 782 cc/m2·day and 10.2 g/m2·day. The enhancement in gas barrier properties can be attributed to the presence of Ti3C2TX nanosheets, which can increase the effective diffusion path length for gases. With the biaxial stretching, the OTR and WVPR of PBAT-1.0 were further reduced to 732 cc/m2·day and 6.5 g/m2·day, respectively. The PBAT composite films with enhanced water vapor and water barrier performance exhibit a potential application in green packaging.
Properties of Lime-Cement Concrete Containing Various Amounts of Waste Tire Powder under Different Ground Moisture Conditions
Authors: Mohammadifar Leili , Miraki Hania , Rahmani Aida , Jahandari Soheil , Mehdizadeh Bahareh , Rasekh Haleh , Samadi Parisa , Samali Bijan
Published: January 2022

Lime-cement concrete (LCC) is a non-structural concrete in which lime and cement are used as the main binders. However, although LCC has many applications in reducing the settlement of foundations and providing a support layer for shallow foundations, little research has been conducted to evaluate its behaviour in various moisture conditions. Previous researchers have studied the feasibility of using waste tires in conventional concrete to alleviate their negative environmental impacts. However, in field projects, rubber has not been widely used because its application leads to the strength reduction of concrete. In the case of LCC, attaining high strengths is not required and thus application of waste tire particles sounds reasonable. This research evaluated the impact of various rubber powder contents on the fresh, geotechnical and durability properties of LCC at different saturation degrees induced by the capillary action and groundwater level increment, which has not been studied before. The results of more than 320 tests showed that the application of tire powder increases workability and decreases the water absorption of LCC. Moreover, all 60-day cured specimens exposed to 100% saturation degree experienced a strength reduction of less than 10% by using rubber powder contents varying from 0 to 20%. Moreover, increasing the saturation degree from 0 to 100% decreased the average compressive strength by 13.5 and 22% for 60-day cured samples of two different mix designs. The results of this research confirm that LCC containing up to 10% rubber powder could be promisingly used underneath or close to the groundwater table without its strength and geotechnical properties being jeopardized due to rubber employment and/or exposure to ground moisture.
Properties and Degradability of Poly(Butylene Adipate-Co-Terephthalate)/Calcium Carbonate Films Modified by Polyethylene Glycol
Authors: Diao Xiaoqian , Zhang Caili , Weng Yunxuan
Published: January 2022

Poly(butylene adipate-co-terephthalate) (PBAT) is a biodegradable polymer synthesized from petrochemical resources. PBAT has an exceptionally high elongation at break values which makes it one of the most promising substitutes for LDPE packaging films. However, the applicability of PBAT films is still limited by low strength and high production costs. In this work, we used polyethylene glycol 600 (PEG-600) as a coating agent to modify the surface of calcium carbonate and improve compatibility with the polymer matrix. A series of PBAT/CaCO3 composite films having different CaCO3 particle size and content of coating agent was prepared using extrusion blow molding. The effect of particle size of CaCO3 filler and the content of a coating agent on the mechanical and rheological properties of composite films have been studied. The biodegradation properties have been tested by burying the samples in soil or keeping them in artificial seawater for 90 days. It was shown that the addition of PEG-600 improves compatibility between the matrix and CaCO3 filler as polar –OH groups of PEG have a high affinity toward the polar surface of CaCO3. Moreover, the hydrophilicity of PEG-600 increased the diffusivity of water molecules and facilitated PBAT degradation. This work provides experimental data and theoretical guidance that support the development of high-performance PBAT/calcium carbonate films for the single use packaging industry.
Special Issue on “Advanced Technology of Waste Treatment”
Authors: Vollprecht Daniel , Sarc Renato
Published: January 2022

The protection of human health and the environment (representing the main reason for waste management), as well as the sustainable use of natural resources, requires chemical, biological, physical and thermal treatment of wastes [...]
Flexible Augmented Reality-Based Health Solution for Medication Weight Establishment
Authors: Berciu Alexandru G. , Dulf Eva H. , Stefan Iulia A.
Published: January 2022

The trend of personalized medicine and the increasing flexibility of drug dosage relevant goals of the 21st century represent the foundation for the current research. To obtain doses smaller than the smallest available, physicians frequently write prescriptions for children and adults, without preserving the integrity of the pill. Moreover, patients purchase large amounts of medication for cost-saving reasons. To support the correct administration of the remedies and the partial alignment to the personalized treatment trend, this paper proposes a flexible and user-friendly solution for determining the medication quantity given to patients, using augmented reality and optical character recognition algorithm capabilities. Via the MATLAB development environment and a Logitech HD Pro C920 webcam, the results were 80% correct in identifying the cutting position of the pill, by means of the Hough transform, and 30% correct in weight recognition exploitation using an optical character recognition (OCR) algorithm. In future work, a higher resolution camera and a more powerful computer can be used to increase the percentages mentioned above. In addition, a 3D scan of the pill fragmentation, combined with the weight recognition functionality, could increase the accuracy of the splitting procedure, conducted by the patient or the patient caretaker.
Ursolic Acid Suppresses Oncostatin M Expression through Blockade of PI3K/Akt/NF-κB Signaling Processes in Neutrophil-like Differentiated HL-60 Cells
Authors: Han Na-Ra , Ko Seong-Gyu , Park Hi-Joon , Moon Phil-Dong
Published: January 2022

Cytokine oncostatin M (OSM) plays an important role in a variety of inflammatory reactions and is mainly produced in neutrophils in inflammatory diseases. While natural pentacyclic triterpenoid ursolic acid (UA) possesses a wide range of beneficial effects, such as anti-oxidant, anti-tumor, and anti-inflammatory, the regulatory processes of OSM suppression by UA in neutrophils are still poorly understood. This study was aimed at examining how UA regulates OSM expression in neutrophil-like differentiated (d)HL-60 cells. Enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, and immunoblotting were employed to analyze the effects of UA. Whereas stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) led to elevations of OSM production and mRNA expression, these elevations were lowered by treatment with UA in neutrophil-like dHL-60 cells. When the cells were exposed to GM-CSF, phosphorylated levels of phosphatidylinositol 3-kinase, Akt, and nuclear factor-kB were upregulated. However, the upregulations were diminished by treatment with UA in neutrophil-like dHL-60 cells. The results of this study proposed that UA might relieve inflammatory diseases via inhibition of OSM.
Catalytic Transformation of Biomass-Derived Glucose by One-Pot Method into Levulinic Acid over Na-BEA Zeolite
Authors: Sobuś Natalia , Czekaj Izabela
Published: January 2022

This article presents the results of the conversion of biomass-based glucose to levulinic acid (LA) with the use of Na-BEA commercial zeolite catalyst. For this purpose, synthetic zeolite BEA was used as a matrix. The glucose conversion process with the participation of Na-BEA zeolite allowed the following acids to be obtained: levulinic acid, lactic acid, pyruvic acid and formic acid. The highest yield of levulinic acid was achieved when processed for 1–5 h at 200–250 °C with 0.1 g and 0.6 g of Na-BEA catalyst. We also compare the one-pot heterogeneous process with similar homogeneous process using H2SO4 as catalyst.
A Study on Updating the Model for Monitoring and Evaluation of Involuntary Resettlement Based on the Experience of China
Authors: Lian Huan , Shi Guoqing , Xu Juan
Published: January 2022

The monitoring and evaluation (M&E) of involuntary resettlement has been implemented for over 30 years since being introduced, achieving significant results in preventing resettlement risks and safeguarding the rights and interests of the persons affected (APs). However, the situation surrounding resettlement has changed significantly over these decades, as the interests of the APs have become more diverse and their social class differentiation has become more pronounced, implying that approaches regarding the governance of resettlement risks must be adjusted. Based on the experience of China, we intend to update the original model for M&E of involuntary resettlement, proposing that the two monitoring systems for risk-susceptible groups and the APs’ development should be set up separately in the monitoring model, and specific monitoring indicators defined within each system. In terms of the evaluation model, we introduce the meta-model of evaluation to strengthen the organic relationship among various evaluation units and enhance the overall capacity of the evaluation. Furthermore, the evaluation should be implemented in general resettlement, risk-susceptible groups resettlement and APs’ development.
Application of Optimization and Modeling for the Composting Process Enhancement
Authors: Sokač Tea , Valinger Davor , Benković Maja , Jurina Tamara , Gajdoš Kljusurić Jasenka , Radojčić Redovniković Ivana , Jurinjak Tušek Ana
Published: January 2022

Composting is a more environmentally friendly and cost-effective alternative to digesting organic waste and turning it into organic fertilizer. It is a biological process in which polymeric waste materials contained in organic waste are biodegraded by fungi and bacteria. Temperature, pH, moisture content, C/N ratio, particle size, nutrient content and oxygen supply all have an impact on the efficiency of the composting process. To achieve optimal composting efficiency, all of these variables and their interactions must be considered. To this end, statistical optimization techniques and mathematical modeling approaches have been developed over the years. In this paper, an overview of optimization and mathematical modeling approaches in the field of composting processes is presented. The advantages and limitations of optimization and mathematical modeling for improving composting processes are also addressed.
Developing and Regenerating Cofactors for Sustainable Enzymatic CO2 Conversion
Authors: Zhang Zhibo , Zhang Xiangping , Ji Xiaoyan
Published: January 2022

Enzymatic CO2 conversion offers a promising strategy for alleviating global warming and promoting renewable energy exploitation, while the high cost of cofactors is a bottleneck for large-scale applications. To address the challenge, cofactor regeneration is usually coupled with the enzymatic reaction. Meanwhile, artificial cofactors have been developed to further improve conversion efficiency and decrease cost. In this review, the methods, such as enzymatic, chemical, electrochemical, and photochemical catalysis, developed for cofactor regeneration, together with those developed artificial cofactors, were summarized and compared to offer a solution for large-scale enzymatic CO2 conversion in a sustainable way.
Acknowledgment to Reviewers of Prosthesis in 2021
Authors:   Prosthesis Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
MeV Cluster Ion Beam–Material Interaction
Authors: Kaneko Toshiaki
Published: January 2022

This paper treats the characteristic topics of MeV/atom cluster ion beams produced using tandem accelerators both in the production stage and in the penetration stage from the viewpoint of fundamental processes. The former is related to atomic collisions in that production and decay of a cluster ion Cn+ (n=1−4) colliding with a charge-changing rare gas underlined through the electron-loss process. Regarding the latter, relatively small carbon clusters Cn+ (n=2−10) are treated. The reduction effect of the average charge of cluster ions in a material is first presented. Next, the electronic stopping power and the energy loss, the polarization force, and the coulomb explosion under cluster-ion impact are described in the dielectric function form. Alignment and structure effects are stressed. As a large and highly symmetric cluster, the electronic stopping power and the average charge are shown for a C60 cluster ion moving inside a solid. Throughout the paper, it is emphasized that the vicinage effect originating from correlation on spatial structure and orientation of constituent ions plays the key role. Moreover, results obtained in cluster production and penetration phenomena are mostly different from multiplication of those under single-ion impact.
Evangelical Belief and Nonviolent Behavior in Chilean Inmates
Authors: Reyes-Quilodran Claudia Andrea , Guzman Daniela Paz
Published: January 2022

This study examines whether religious beliefs motivate nonviolent behavior and lower rates of recidivism among Chilean inmates. We collected data through in-depth interviews with 174 inmates using open and close-ended questions. The research used a proportional random sample to select participants, principal component analysis to identify similarities and differences between groups, and content analysis to examine answers to the open-ended interview questions. Its findings indicate that evangelical inmates in Chilean prisons are less violent, more likely to follow internal jail regulations, and more cooperative with professionals and officials. This study contributes to the literature because there was no previous evidence in Chile that religious association, religious conviction, or a desire to change criminal behavior is instrumental to achieving better security during inmates’ stays in prison. The results also demonstrate that the presence of a peer group, with its emotional support and provision of a daily routine, is fundamental if inmates are to successfully handle their anxiety and be less violent.