bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Na Takuathung Mingkwan , Klinjan Preeyaporn , Sakuludomkan Wannachai , Dukaew Nahathai , Inpan Ratchanon , Kongta Rattana , Chaiyana Wantida , Teekachunhatean Supanimit , Koonrungsesomboon Nut
Published: February 2023

Skin aging is one of the most concerning issues that occur after menopause. The Genistein Nutraceutical (GEN) product, containing genistein, vitamin E, vitamin B3, and ceramide, has been formulated as a topical anti-aging product for improving the health of postmenopausal women’s facial skin. This study aimed to investigate the efficacy and safety of the GEN product on postmenopausal women’s facial skin. This randomized, double-blind, placebo-controlled trial randomly assigned 50 postmenopausal women to receive either the GEN product (n = 25) or the placebo (PLA) product (n = 25), topically applied twice daily for 6 weeks. The outcome assessments included multiple skin parameters related to skin wrinkling, color, hydration, and facial skin quality at baseline and week 6. The percentage mean changes or absolute mean changes, where appropriate, in skin parameters were compared between the two groups. The mean age of the participants was 55.8 ± 3.4 years. For skin wrinkling and skin color parameters, only skin redness was significantly higher in the GEN group when compared to the PLA group. Following the application of the GEN product, skin hydration increased while fine pores and their area decreased. Subgroup analysis of older women (age ≥ 56 years) with adequate compliance found significant differences between the two groups in the percentage mean changes of most skin wrinkle parameters. The GEN product has benefits for the facial skin of postmenopausal women, particularly those who are older. It can moisturize facial skin, lessen wrinkles, and enhance redness.
Correlation between the Signal Intensity Alteration of Infrapatellar Fat Pad and Knee Osteoarthritis: A Retrospective, Cross-Sectional Study
Authors: Liu Zheng , Wu Jiangyi , Xiang Wei , Wu Jinhui , Huang Shu , Zhou Yizhao , Xia Hui , Ni Zhenhong , Liu Baorong
Published: February 2023

Infrapatellar fat pad (IPFP) inflammation is a common pathological manifestation in knee osteoarthritis (OA). However, the significance of IPFP signal intensity alteration for clinical diagnosis and treatment of knee OA needs further research. We assessed IPFP signal intensity alteration (0–3), IPFP maximum cross-sectional area (CSA) and IPFP depth, meniscus injury, bone marrow edema, and cartilage injury from magnetic-resonance imaging (MRI) in 41 non-KOA patients (K-L grade 0 and grade I) and 68 KOA patients (K-L grade 2,3 and 4). We found that IPFP signaling was altered in all patients with KOA whose alteration was closely related to the K-L grading. We found that the IPFP signal intensity was increased in most OA patients, especially the ones in the late stage. There were significant differences in IPFP maximum CSA and IPFP depth between groups in KOA and non-KOA patients. Moreover, Spearman correlation analysis showed that IPFP signal intensity was moderately positively correlated with age, meniscal injury, cartilage injury, and bone marrow edema, and negatively correlated with height, while not correlated with visual analogue scale (VAS) scoring and body mass index (BMI). In addition, women have higher IPFP inflammation scores on MRI than men. In conclusion, IPFP signal intensity alteration is associated with joint damage in knee OA, which may have clinical significance for diagnosing and treating KOA.
Do Surgeons Anticipate Women’s Hopes and Fears Associated with Prolapse Repair? A Qualitative Analysis in the PROSPERE Trial
Authors: Fritel Xavier , Ravit Marion , Pizzoferrato Anne-Cécile , Campagne-Loiseau Sandrine , Bader Georges , Capmas Perrine , Cosson Michel , Debodinance Philippe , Deffieux Xavier , Fernandez Hervé , Ferry Philippe , Garbin Olivier , Jacquetin Bernard , Legendre Guillaume , Saussine Christian , de Tayrac Renaud , Wagner Laurent , Lucot Jean-Philippe , Fauconnier Arnaud ,   the PROSPERE team
Published: February 2023

Women’s preoperative perceptions of pelvic-floor disorders may differ from those of their physicians. Our objective was to specify women’s hopes and fears before cystocele repair, and to compare them to those that surgeons anticipate. We performed a secondary qualitative analysis of data from the PROSPERE trial. Among the 265 women included, 98% reported at least one hope and 86% one fear before surgery. Sixteen surgeons also completed the free expectations-questionnaire as a typical patient would. Women’s hopes covered seven themes, and women’s fears eleven. Women’s hopes were concerning prolapse repair (60%), improvement of urinary function (39%), capacity for physical activities (28%), sexual function (27%), well-being (25%), and end of pain or heaviness (19%). Women’s fears were concerning prolapse relapse (38%), perioperative concerns (28%), urinary disorders (26%), pain (19%), sexual problems (10%), and physical impairment (6%). Surgeons anticipated typical hopes and fears which were very similar to those the majority of women reported. However, only 60% of the women reported prolapse repair as an expectation. Women’s expectations appear reasonable and consistent with the scientific literature on the improvement and the risk of relapse or complication related to cystocele repair. Our analysis encourages surgeons to consider individual woman’s expectations before pelvic-floor repair.
Overview of Chemotherapy for Gastric Cancer
Authors: Sato Yasushi , Okamoto Koichi , Kida Yoshifumi , Mitsui Yasuhiro , Kawano Yutaka , Sogabe Masahiro , Miyamoto Hiroshi , Takayama Tetsuji
Published: February 2023

Gastric cancer (GC) is one of the most clinically challenging cancers worldwide. Over the past few years, new molecular-targeted agents and immunotherapy have markedly improved GC prognosis. Human epidermal growth factor receptor 2 (HER2) expression is a key biomarker in first-line chemotherapy for unresectable advanced GC. Further, the addition of trastuzumab to cytotoxic chemotherapy has extended the overall survival of patients with HER2-positive advanced GC. In HER2-negative GC, the combination of nivolumab, an immune checkpoint inhibitor, and a cytotoxic agent has been demonstrated to prolong the overall survival of GC patients. Ramucirumab and trifluridine/tipiracil, which are second- and third-line treatments for GC, and trastuzumab deruxtecan, an antibody–drug conjugate for HER2-positive GC, have been introduced in clinics. New promising molecular-targeted agents are also being developed, and combination therapy comprising immunotherapy and molecular-targeted agents is expected. As the number of available drugs increases, it is important to understand the target biomarkers and drug characteristics and select the optimal therapy for each patient. For resectable disease, differences in the extent of standard lymphadenectomy between Eastern and Western countries have led to different standard treatments: perioperative (neoadjuvant) and adjuvant therapy. This review aimed to summarize recent advances in chemotherapy for advanced GC.
Interaction with Virtual Humans and Effect of Emotional Expressions: Anger Matters!
Authors: Rapuano Mariachiara , Iachini Tina , Ruggiero Gennaro
Published: February 2023

Today we are experiencing a hybrid real-virtual society in which the interaction with virtual humans is normal and “quasi-social”. Understanding the way we react to the interaction with virtual agents and the impact of emotions on social dynamics in the virtual world is fundamental. Therefore, in this study we investigated the implicit effect of emotional information by adopting a perceptual discrimination task. Specifically, we devised a task that explicitly required perceptual discrimination of a target while involving distance regulation in the presence of happy, neutral, or angry virtual agents. In two Immersive Virtual Reality experiments, participants were instructed to discriminate a target on the virtual agents’ t-shirts, and they had to provide the response by stopping the virtual agents (or themselves) at the distance where they could identify the target. Thus, facial expressions were completely irrelevant to the perceptual task. The results showed that the perceptual discrimination implied a longer response time when t-shirts were worn by angry rather than happy or neutral virtual agents. This suggests that angry faces interfered with the explicit perceptual task people had to perform. From a theoretical standpoint, this anger-superiority effect could reflect an ancestral fear/avoidance mechanism that prompts automatic defensive reactions and bypasses other cognitive processes.
Prognostic Prediction Model for Glioblastoma: A Ferroptosis-Related Gene Prediction Model and Independent External Validation
Authors: Chen Wenlin , Lei Chuxiang , Wang Yuekun , Guo Dan , Zhang Sumei , Wang Xiaoxi , Zhang Zixin , Wang Yu , Ma Wenbin
Published: February 2023

Glioblastoma (GBM) is the most common primary malignant intracranial tumor with a poor prognosis. Ferroptosis is a newly discovered, iron-dependent, regulated cell death, and recent studies suggest its close correlation to GBM. The transcriptome and clinical data were obtained for patients diagnosed with GBM from TCGA, GEO, and CGGA. Ferroptosis-related genes were identified, and a risk score model was constructed using Lasso regression analyses. Survival was evaluated by univariate or multivariate Cox regressions and Kaplan–Meier analyses, and further analyses were performed between the high- and low-risk groups. There were 45 ferroptosis-related different expressed genes between GBM and normal brain tissues. The prognostic risk score model was based on four favorable genes, CRYAB, ZEB1, ATP5MC3, and NCOA4, and four unfavorable genes, ALOX5, CHAC1, STEAP3, and MT1G. A significant difference in OS between high- and low-risk groups was observed in both the training cohort (p < 0.001) and the validation cohorts (p = 0.029 and 0.037). Enrichment analysis of pathways and immune cells and functioning was conducted between the two risk groups. A novel prognostic model for GBM patients was developed based on eight ferroptosis-related genes, suggesting a potential prediction effect of the risk score model in GBM.
The Combined Effect of Polygenic Risk Score and Prostate Health Index in Chinese Men Undergoing Prostate Biopsy
Authors: Ruan Xiaohao , Huang Da , Huang Jingyi , Huang Jinlun , Zhan Yongle , Wu Yishuo , Ding Qiang , Xu Danfeng , Jiang Haowen , Xue Wei , Na Rong
Published: February 2023

To date, the combined effect of polygenic risk score (PRS) and prostate health index (phi) on PCa diagnosis in men undergoing prostate biopsy has never been investigated. A total of 3166 patients who underwent initial prostate biopsy in three tertiary medical centers from August 2013 to March 2019 were included. PRS was calculated on the basis of the genotype of 102 reported East-Asian-specific risk variants. It was then evaluated in the univariable or multivariable logistic regression models that were internally validated using repeated 10-fold cross-validation. Discriminative performance was assessed by area under the receiver operating curve (AUC) and net reclassification improvement (NRI) index. Compared with men in the first quintile of age and family history adjusted PRS, those in the second, third, fourth, and fifth quintiles were 1.86 (odds ratio, 95% confidence interval (CI): 1.34–2.56), 2.07 (95%CI: 1.50–2.84), 3.26 (95%CI: 2.36–4.48), and 5.06 (95%CI: 3.68–6.97) times as likely to develop PCa (all p < 0.001). Adjustment for other clinical parameters yielded similar results. Among patients with prostate-specific antigen (PSA) at 2–10 ng/mL or 2–20 ng/mL, PRS still had an observable ability to differentiate PCa in the group of prostate health index (phi) at 27–36 (Ptrend < 0.05) or >36 (Ptrend ≤ 0.001). Notably, men with moderate phi (27–36) but highest PRS (top 20% percentile) would have a comparable risk of PCa (positive rate: 26.7% or 31.3%) than men with high phi (>36) but lowest PRS (bottom 20% percentile positive rate: 27.4% or 34.2%). The combined model of PRS, phi, and other clinical risk factors provided significantly better performance (AUC: 0.904, 95%CI: 0.887–0.921) than models without PRS. Adding PRS to clinical risk models could provide significant net benefit (NRI, from 8.6% to 27.6%), especially in those early onset patients (NRI, from 29.2% to 44.9%). PRS may provide additional predictive value over phi for PCa. The combination of PRS and phi that effectively captured both clinical and genetic PCa risk is clinically practical, even in patients with gray-zone PSA.
Clinicopathological Features of Kidney Injury Related to Immune Checkpoint Inhibitors: A Systematic Review
Authors: Xu Ling-Yi , Zhao Hai-Ya , Yu Xiao-Juan , Wang Jin-Wei , Zheng Xi-Zi , Jiang Lei , Wang Su-Xia , Liu Gang , Yang Li
Published: February 2023

(1) Background: Despite increasing recognition of immune checkpoint inhibitors (ICIs) and kidney immune-related adverse events (IRAEs), no large-sample studies have assessed the pathological characteristics and outcomes of biopsy-proven kidney IRAEs. (2) Methods: We comprehensively searched PubMed, Embase, Web of Science, and Cochrane for case reports, case series, and cohort studies for patients with biopsy-proven kidney IRAEs. All data were used to describe pathological characteristics and outcomes, and individual-level data from case reports and case series were pooled to analyze risk factors associated with different pathologies and prognoses. (3) Results: In total, 384 patients from 127 studies were enrolled. Most patients were treated with PD-1/PD-L1 inhibitors (76%), and 95% presented with acute kidney disease (AKD). Acute tubulointerstitial nephritis/acute interstitial nephritis (ATIN/AIN) was the most common pathologic type (72%). Most patients (89%) received steroid therapy, and 14% (42/292) required RRT. Among AKD patients, 17% (48/287) had no kidney recovery. Analyses of pooled individual-level data from 221 patients revealed that male sex, older age, and proton pump inhibitor (PPI) exposure were associated with ICI-associated ATIN/AIN. Patients with glomerular injury had an increased risk of tumor progression (OR 2.975; 95% CI, 1.176, 7.527; p = 0.021), and ATIN/AIN posed a decreased risk of death (OR 0.164; 95% CI, 0.057, 0.473; p = 0.001). (4) Conclusions: We provide the first systematic review of biopsy-proven ICI-kidney IRAEs of interest to clinicians. Oncologists and nephrologists should consider obtaining a kidney biopsy when clinically indicated.
Artificial Intelligence (AI) versus POCUS Expert: A Validation Study of Three Automatic AI-Based, Real-Time, Hemodynamic Echocardiographic Assessment Tools
Authors: Gohar Eyal , Herling Amit , Mazuz Mor , Tsaban Gal , Gat Tomer , Kobal Sergio , Fuchs Lior
Published: February 2023

Background: Point Of Care Ultra-Sound (POCUS) is an operator dependent modality. POCUS examinations usually include ‘Eyeballing’ the inspected anatomical structure without conducting accurate measurements due to complexity and insufficient time. Automatic real time measuring tools can make accurate measurements fast and simple and dramatically increase examination reliability while saving the operator much time and effort. In this study we aim to assess three automatic tools which are integrated into the Venue™ device by GE: the automatic ejection fraction, velocity time integral, and inferior vena cava tools in comparison to the gold standard—an examination by a POCUS expert. Methods: A separate study was conducted for each of the three automatic tools. In each study, cardiac views were acquired by a POCUS expert. Relevant measurements were taken by both an auto tool and a POCUS expert who was blinded to the auto tool’s measurement. The agreement between the POCUS expert and the auto tool was measured for both the measurements and the image quality using a Cohen’s Kappa test. Results: All three tools have shown good agreement with the POCUS expert for high quality views: auto LVEF (0.498; p < 0.001), auto IVC (0.536; p = 0.009), and the auto VTI (0.655; p = 0.024). Auto VTI has also shown a good agreement for medium quality clips (0.914; p < 0.001). Image quality agreement was significant for the auto EF and auto IVC tools. Conclusions: The Venue™ show a high agreement with a POCUS expert for high quality views. This shows that auto tools can provide reliable real time assistance in performing accurate measurements, but do not reduce the need of a good image acquisition technique.
Building Orientation and Post Processing of Ti6Al4V Produced by Laser Powder Bed Fusion Process
Authors: Rovetta Rosaria , Ginestra Paola , Ferraro Rosalba Monica , Zohar-Hauber Keren , Giliani Silvia , Ceretti Elisabetta
Published: February 2023

Laser powder bed fusion, particularly the selective laser melting (SLM), is an additive manufacturing (AM) technology used to produce near-net-shaped engineering components for biomedical applications, especially in orthopaedics. Ti6Al4V is commonly used for producing orthopaedic implants using SLM because it has excellent mechanical qualities, a high level of biocompatibility, and corrosion resistance. However, the main problems associated with this process are the result of its surface properties: it has to be able to promote cell attachment but, at the same time, avoid bacteria colonization. Surface modification is used as a post-processing technique to provide items the unique qualities that can improve their functionality and performance in particular working conditions. The goal of this work was to produce and analyse Ti6Al4V samples fabricated by SLM with different building directions in relation to the building plate (0° and 45°) and post-processed by anodization and passivation. The results demonstrate how the production and post processes had an impact on osteoblast attachment, mineralization, and osseointegration over an extended period of time. Though the anodization treatment result was cytotoxic, the biocompatibility of as-built specimens and specimens after passivation treatment was confirmed. In addition, it was discovered that effective post-processing increases the mineralization of these types of 3D-printed surfaces.
Effects of Internal Waves on Acoustic Temporal Coherence in the South China Sea
Authors: Gao Fei , Hu Ping , Xu Fanghua , Li Zhenglin , Qin Jixing
Published: February 2023

An acoustic experiment to measure the sound field during internal wave activity was conducted in the South China Sea. During the experiment, a train of strong internal solitary waves (ISWs) moved from the acoustic source to the receiver array along the acoustic path, and the propagation direction of the ISWs train was almost parallel to the acoustic path. Here, a study of the characteristics and physical mechanisms of the acoustic temporal coherence in this scenario is reported. The temporal coherence was analyzed by using the simulation results and experimental data. The results show that the temporal correlation coefficients oscillate quasi-periodically with both time and time delay, and the predominant oscillation periods are the same as the periods of the ISWs. The predominant fluctuation frequencies of the sound field correspond to some specific modes and lead to the periodicity of the temporal correlation coefficients. In the shallow layer, the spectrum structures of the temporal correlation coefficients are simpler because of the fewer effective modes.
Resistance of Black Aspergilli Species from Grape Vineyards to SDHI, QoI, DMI, and Phenylpyrrole Fungicides
Authors: Testempasis Stefanos I. , Karaoglanidis George S.
Published: February 2023

Fungicide applications constitute a management practice that reduces the size of fungal populations and by acting as a genetic drift factor, may affect pathogen evolution. In a previous study, we showed that the farming system influenced the population structure of the Aspergillus section Nigri species in Greek vineyards. The current study aimed to test the hypothesis that the differences in the population structure may be associated with the selection of fungicide-resistant strains within the black aspergilli populations. To achieve this, we determined the sensitivity of 102, 151, 19, and 22 for the A. uvarum, A. tubingensis, A. niger, and A. carbonarious isolates, respectively, originating either from conventionally-treated or organic vineyards to the fungicides fluxapyroxad-SDHIs, pyraclostrobin-QoIs, tebuconazole-DMIs, and fludioxonil-phenylpyrroles. The results showed widespread resistance to all four fungicides tested in the A. uvarum isolates originating mostly from conventional vineyards. In contrast, all the A. tubingensis isolates tested were sensitive to pyraclostrobin, while moderate frequencies of only lowly resistant isolates were identified for tebuconazole, fludioxonil, and fluxapyroxad. Sequencing analysis of the corresponding fungicide target encoding genes revealed the presence of H270Y, H65Q/S66P, and G143A mutations in the sdhB, sdhD, and cytb genes of A. uvarum resistant isolates, respectively. No mutations in the Cyp51A and Cyp51B genes were detected in either the A. uvarum or A. tubingensis isolates exhibiting high or low resistance levels to DMIs, suggesting that other resistance mechanisms are responsible for the observed phenotype. Our results support the initial hypothesis for the contribution of fungicide resistance in the black aspergilli population structure in conventional and organic vineyards, while this is the first report of A. uvarum resistance to SDHIs and the first documentation of H270Y or H65Q/S66P mutations in sdhB, sdhD, and of the G143A mutation in the cytb gene of this fungal species.
Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review
Authors: Budea Camelia , Bratosin Felix , Bogdan Iulia , Bota Adrian , Turaiche Mirela , Tirnea Livius , Stoica Carmen , Csep Andrei , Feciche Bogdan , Pescariu Silvius , Popa Malina , Mavrea Adelina , Bumbu Bogdan , Bandi Satya , Marincu Iosif
Published: February 2023

Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research employed three databases (PubMed, Wiley, and Web of Science), with a primary search for studies that have described cases of IE in patients older than 65 years. From a total of 555 articles, 10 were selected for inclusion in the current study, comprising a total of 2222 patients with a confirmed diagnosis of IE. The primary findings were an increased incidence of staphylococcal and streptococcal infections (33.4% and32.0%, respectively), an increased prevalence of comorbidities, namely, cardiovascular disease, diabetes, and cancer, and a significantly greater mortality risk than the younger group. Regarding mortality risks, the pooled odds ratio for cardiac disorders was OR = 3.81, septic shock OR = 8.22, renal complications OR = 3.75, and advancing age OR = 3.54 were most frequently mentioned. Taking into consideration the fact that the majority of the elderly population suffers from significant complications and is unable to undergo surgery due to an increased risk of complications after the procedure, it is imperative that effective treatment methods should be investigated.
Patient Satisfaction and Impact on Oral Health after Maxillary Rehabilitation Using a Personalized Additively Manufactured Subperiosteal Jaw Implant (AMSJI)
Authors: Van den Borre Casper , De Neef Björn , Loomans Natalie A. J. , Rinaldi Marco , Nout Erik , Bouvry Peter , Naert Ignace , Mommaerts Maurice Y.
Published: February 2023

Subperiosteal implants (SIs) were first developed by Dahl in 1941 for oral rehabilitation in case of severe jaw atrophy. Over time, this technique was abandoned due to the high success rate of endosseous implants. The emergence of patient-specific implants and modern dentistry allowed a revisitation of this 80-year-old concept resulting in a novel “high-tech” SI implant. This study evaluates the clinical outcomes in forty patients after maxillary rehabilitation with an additively manufactured subperiosteal jaw implant (AMSJI®). The oral health impact profile-14 (OHIP-14) and numerical rating (NRS) scale were used to assess patient satisfaction and evaluate oral health. In total, fifteen men (mean age: 64.62 years, SD ± 6.75 years) and twenty-five women (mean age: 65.24 years, SD ± 6.77 years) were included, with a mean follow-up time of 917 days (SD ± 306.89 days) after AMSJI installation. Patients reported a mean OHIP-14 of 4.20 (SD ± 7.10) and a mean overall satisfaction based on the NRS of 52.25 (SD ± 4.00). Prosthetic rehabilitation was achieved in all patients. AMSJI is a valuable treatment option for patients with extreme jaw atrophy. Patients enjoy treatment benefits resulting in high patient satisfaction rates and impact on oral health.
L-Carnitine and Chronic Kidney Disease: A Comprehensive Review on Nutrition and Health Perspectives
Authors: Sharma Bharti , Yadav Dinesh Kumar
Published: February 2023

Progressive segmental glomerulosclerosis is acknowledged as a characteristic of Chronic Kidney Disease (CKD). It is a major health issue that exponentially reduces health and economy and also causes serious morbidity and mortality across the globe. This review is aimed at comprehending the health perspectives of L-Carnitine (LC) as an adjuvant regimen for alleviating CKD and its associated complications. The data were gathered from different online databases such as Science Direct, Google Scholar, ACS publication, PubMed, Springer, etc., using keywords such as CKD/Kidney disease, current epidemiology and its prevalence, LC supplementations, sources of LC, anti-oxidant and anti-inflammatory potential of LC and its supplementation for mimicking the CKD and its associated problem, etc. Various items of literature concerning CKD were gathered and screened by experts based on their inclusion and exclusion criteria. The findings suggest that, among the different comorbidities such as oxidative stress and inflammatory stress, erythropoietin-resistant anemia, intradialytic hypotension, muscle weakness, myalgia, etc., are considered as the most significant onset symptoms in CKD or hemodialysis patients. LC or creatine supplementation provides an effective adjuvant or therapeutic regimen that significantly reduces oxidative and inflammatory stress and erythropoietin-resistant anemia and evades comorbidities such as tiredness, impaired cognition, muscle weakness, myalgia, and muscle wasting. However, no significant changes were found in biochemical alteration such as creatinine, uric acid, urea, etc., after creatine supplementation in a patient with renal dysfunction. The expert-recommended dose of LC or creatine to a patient is approached for better outcomes of LC as a nutritional therapy regimen for CKD-associated complications. Hence, it can be suggested that LC provides an effective nutritional therapy to ameliorate impaired biochemicals and kidney function and to treat CKD and its associated complications.
Dynamic Decentralized Reputation System from Blockchain and Secure Multiparty Computation
Authors: Mrabet Khalid , El Bouanani Faissal , Ben-Azza Hussain
Published: February 2023

In decentralized environments, such as mobile ad hoc networks (MANETs) and wireless sensor networks (WSNs), traditional reputation management systems are not viable due to their dependence on a central authority that is both accessible and trustworthy for all participants. This is particularly challenging in light of the dynamic nature of these networks. To overcome these limitations, our proposed solution utilizes blockchain technology to maintain global reputation information while remaining fully decentralized, and to secure multiparty computation to ensure privacy. Our system is not limited to specific settings, such as buyer/seller or provider/client scenarios, where only a subset of the network are raters while the others are ratees. Instead, it allows all nodes to participate in both rating and being rated. In terms of security, the system maintains feedback privacy in the semi-honest model, even in the presence of up to n−2 dishonest parties, while requiring only O(n) messages and having an O(n) computation overhead. Furthermore, the adopted techniques enable the system to achieve unique characteristics such as accessibility, consistency, and verifiability, as supported by the security analysis provided.
Optimal Regional Allocation of Future Population and Employment under Urban Boundary and Density Constraints: A Spatial Interaction Modeling Approach
Authors: Lee David Jung-Hwi , Guldmann Jean-Michel
Published: February 2023

This paper develops an optimization modeling framework to select strategies of land development and population and employment densities for a growing metropolitan area. The modeling core involves a non-linear commuting model, which accounts for spatial structure variables and is empirically estimated by Tobit regression. This commuting model is then embedded into a non-linear optimization model that allocates increments in the population and employment (activities) to available land, while minimizing the total future commuting costs under various combinations of land expansion boundaries and population and employment densities. The resulting minimum cost surface is approximated via polynomial regression and combined with land development and congestion cost functions to derive the overall optimal strategy. These models are estimated and calibrated with data from the Census Transportation Planning Package (CTPP) and Auditor’s property database, and are applied to the Fredericksburg metropolitan area, Virginia. The results demonstrate that the optimal development densities are very sensitive to the congestion cost function. A land development strategy that allows for limited sprawl might be a smart policy to reduce both regional vehicle mile travel (VMT) and related congestion and pollution.
Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study
Authors: Paganelli Alessia , Naselli Andrea Giovanni , Bertoni Laura , Rossi Elena , Azzoni Paola , Pisciotta Alessandra , Cesinaro Anna Maria , Benassi Luisa , Kaleci Shaniko , Garbarino Federico , Ferrari Barbara , Fiorentini Chiara , Reggiani Camilla , Magnoni Cristina
Published: February 2023

Background: MatriDerm and Integra are both widely used collagenic acellular dermal matrices (ADMs) in the surgical setting, with similar characteristics in terms of healing time and clinical indication. The aim of the present study is to compare the two ADMs in terms of clinical and histological results in the setting of dermato-oncological surgery. Methods: Ten consecutive patients with medical indications to undergo surgical excision of skin cancers were treated with a 2-step procedure at our Dermatologic Surgery Unit. Immediately after tumor removal, both ADMs were positioned on the wound bed, one adjacent to the other. Closure through split-thickness skin grafting was performed after approximately 3 weeks. Conventional histology, immunostaining and ELISA assay were performed on cutaneous samples at different timepoints. Results: No significant differences were detected in terms of either final clinical outcomes or in extracellular matrix content of the neoformed dermis. However, Matriderm was observed to induce scar retraction more frequently. In contrast, Integra was shown to carry higher infectious risk and to be more slowly reabsorbed into the wound bed. Sometimes foreign body-like granulomatous reactions were also observed, especially in Integra samples. Conclusions: Even in the presence of subtle differences between the ADMs, comparable global outcomes were demonstrated after dermato-oncological surgery.
Cerebral Venous Sinus Thrombosis Following an mRNA COVID-19 Vaccination and Recent Oral Contraceptive Use
Authors: Frommeyer Timothy C. , Wu Tongfan , Gilbert Michael M. , Brittain Garrett V. , Fuqua Stephen P.
Published: February 2023

Rising concerns of cerebral venous sinus thrombosis (CVST) and other forms of venous thromboembolism have been associated with the SARS-CoV-2 vaccinations. Adverse effects with vector-based vaccines are well documented in the literature, while less is known about the mRNA vaccines. This report documents a case of CVST in a 32-year-old female patient who received her second Pfizer mRNA COVID-19 vaccination 16 days prior to hospital admission and had started oral combined contraceptives approximately 4 months beforehand. Clinicians should be cognizant of the possibility that mRNA vaccines, when combined with other risk factors like oral contraceptive pill use, may enhance one’s hypercoagulable status.
Olea europaea Leaf Phenolics Oleuropein, Hydroxytyrosol, Tyrosol, and Rutin Induce Apoptosis and Additionally Affect Temozolomide against Glioblastoma: In Particular, Oleuropein Inhibits Spheroid Growth by Attenuating Stem-like Cell Phenotype
Authors: Ercelik Melis , Tekin Cagla , Tezcan Gulcin , Ak Aksoy Secil , Bekar Ahmet , Kocaeli Hasan , Taskapilioglu Mevlut Ozgur , Eser Pınar , Tunca Berrin
Published: February 2023

The effects of Olea europaea leaf extract (OLE) phenolics, including oleuropein (OL), hydroxytyrosol (HT), tyrosol (TYR), and rutin against glioblastoma (GB), independently and in combination with temozolomide (TMZ), were investigated in T98G and A172 cells. Cell growth was assessed by WST-1, real-time cell analysis, colony formation, and cell cycle distribution assays. A dual acridine orange propidium iodide (AO/PI) staining and annexin V assay determined cell viability. A sphere-forming assay, an intracellular oxidative stress assay, and the RNA expression of CD133 and OCT4 investigated the GB stem-like cell (GSC) phenotype. A scratch wound-healing assay evaluated migration capacity. OL was as effective as OLE in terms of apoptosis promotion (p < 0.001) and GSC inhibition (p < 0.001). HT inhibited cell viability, GSC phenotype, and migration rate (p < 0.001), but its anti-GB effect was less than the total effect of OLE alone. Rutin decreased reactive oxygen species production and inhibited colony formation and cell migration (p < 0.001). TYR demonstrated the least effect. The additive effects of OL, HT, TYR and rutin with TMZ were significant (p < 0.001). Our data suggest that OL may represent a novel therapeutic approach against GB cells, while HT and rutin show promise in increasing the efficacy of TMZ therapy.
The Modification of Cell Wall Properties Is Involved in the Growth Inhibition of Rice Coleoptiles Induced by Lead Stress
Authors: Wakabayashi Kazuyuki , Soga Kouichi , Hoson Takayuki , Masuda Harue
Published: February 2023

Lead (Pb) is a widespread heavy metal pollutant that interferes with plant growth. In this study, we investigated the effects of Pb on the mechanical and chemical properties of cell walls and on the growth of coleoptiles of rice (Oryza sativa L.) seedlings grown in the air (on moistened filter paper) and underwater (submerged condition). Coleoptile growth of air-grown seedlings was reduced by 40% by the 3 mM Pb treatment, while that of water-grown ones was reduced by 50% by the 0.5 mM Pb. Although the effective concentration of Pb for growth inhibition of air-grown coleoptiles was much higher than that of water-grown ones, Pb treatment significantly decreased the mechanical extensibility of the cell wall in air- and water-grown coleoptiles, when it inhibited their growth. Among the chemical components of coleoptile cell walls, the amounts of cell wall polysaccharides per unit fresh weight and unit length of coleoptile, which represent the thickness of the cell wall, were significantly increased in response to the Pb treatment (3 mM and 0.5 mM Pb for air- and water-grown seedlings, respectively), while the levels of cell wall-bound diferulic acids (DFAs) and ferulic acids (FAs) slightly decreased. These results indicate that Pb treatment increased the thickness of the cell wall but not the phenolic acid-mediated cross-linking structures within the cell wall in air- and water-grown coleoptiles. The Pb-induced cell wall thickening probably causes the mechanical stiffening of the cell wall and thus decreases cell wall extensibility. Such modifications of cell wall properties may be associated with the inhibition of coleoptile growth. The results of this study provide a new finding that Pb-induced cell wall remodeling contributes to the regulation of plant growth under Pb stress conditions via the modification of the mechanical property of the cell wall.
Advances in Analgosedation and Periprocedural Care for Gastrointestinal Endoscopy
Authors: Skiljic Sonja , Budrovac Dino , Cicvaric Ana , Neskovic Nenad , Kvolik Slavica
Published: February 2023

The number and complexity of endoscopic gastrointestinal diagnostic and therapeutic procedures is globally increasing. Procedural analgosedation during gastrointestinal endoscopic procedures has become the gold standard of gastrointestinal endoscopies. Patient satisfaction and safety are important for the quality of the technique. Currently there are no uniform sedation guidelines and protocols for specific gastrointestinal endoscopic procedures, and there are several challenges surrounding the choice of an appropriate analgosedation technique. These include categories of patients, choice of drug, appropriate monitoring, and medical staff providing the service. The ideal analgosedation technique should enable the satisfaction of the patient, their maximum safety and, at the same time, cost-effectiveness. Although propofol is the gold standard and the most used general anesthetic for endoscopies, its use is not without risks such as pain at the injection site, respiratory depression, and hypotension. New studies are looking for alternatives to propofol, and drugs like remimazolam and ciprofol are in the focus of researchers’ interest. New monitoring techniques are also associated with them. The optimal technique of analgosedation should provide good analgesia and sedation, fast recovery, comfort for the endoscopist, patients’ safety, and will have financial benefits. The future will show whether these new drugs have succeeded in these goals.
The Rhythm of Breath in Natsume Sōseki’s Recollecting and Such
Authors: Mewhinney Matthew
Published: February 2023

This article examines Japanese novelist Natsume Sōseki’s (1867–1916) memoir Recollecting and Such (Omoidasu koto nado; 1910). I argue that Sōseki invites the reader to imagine breath through his literary representation of both physiological and metaphysical experience and the rhythm of the narrative’s experimental poetic form. In concert with the theme of this special issue, I show how Recollecting and Such self-reflexively restores and evokes the corporeal experience of sensation beyond just visual perception: the narrative reveals itself as a poetic form of measurement and its first-person narrator a “rhythmanalyst”, someone who listens to the internal rhythms of his own body and then to that of the external world (Henri Lefebvre). The narrator’s awareness of the duration, frequency, and intensity of sensation as well as his regular compositions of metered verse—haiku and kanshi (traditional Chinese poetry as practiced in Japan; Sinitic verse)—are ways that the narrative measures the limits of life, memory, and sensory experience. The oscillation between prose and poetry in the narrative generates an organic rhythm, simulating the long and short breaths of a convalescing body, which invites the reader to breathe together—“to conspire” in the literal sense—with the text as a form of sympathy.
Extensive Stability Assessment of TiO2/Polyvinyl Ether Nanolubricant with Physical Homogenization
Authors: Ismail Mohd Farid , Azmi Wan Hamzah , Mamat Rizalman , Sharma Korada Viswanatha , Ali Hafiz Muhammad
Published: February 2023

Proper preparation and stability evaluation of the nanolubricant shall be established when applying the nanoparticle dispersion technique in a two-phase system. The stability of the nanolubricant ensures the maximum benefit gained from the dispersion of nanoparticles in specified Polyvinyl ether (PVE). In this study, TiO2/PVE nanolubricant was prepared using two methods of physical homogenization: high-speed homogenizer (HSH) and ultrasonication bath. The HSH used a preparation time of up to 300 s in the stability assessment. Meanwhile, the ultrasonication bath had a preparation time of 1, 3, 5, and 7 h. The stability condition of the nanolubricant was evaluated using photo capturing, ultraviolet-visible (UV-Vis) spectrophotometer, zeta potential, and zeta sizer. A sample with 180 s of preparation time shows the best stability condition from HSH. The nanolubricant with ultrasonication offers excellent stability at 5 h of homogenizing time with a concentration ratio of more than 90% for up to 30 days of observation. In conclusion, ultrasonication homogenizing methods show better results than HSH with a zeta potential of more than 60 mV. In addition, HSH can be recommended as an optional method to produce nanolubricant with a low preparation time for immediate use.
TGSNet: Multi-Field Feature Fusion for Glass Region Segmentation Using Transformers
Authors: Hu Xiaohang , Gao Rui , Yang Seungjun , Cho Kyungeun
Published: February 2023

Glass is a common object in living environments, but detecting it can be difficult because of the reflection and refraction of various colors of light in different environments; even humans are sometimes unable to detect glass. Currently, many methods are used to detect glass, but most rely on other sensors, which are costly and have difficulty collecting data. This study aims to solve the problem of detecting glass regions in a single RGB image by concatenating contextual features from multiple receptive fields and proposing a new enhanced feature fusion algorithm. To do this, we first construct a contextual attention module to extract backbone features through a self-attention approach. We then propose a VIT-based deep semantic segmentation architecture called MFT, which associates multilevel receptive field features and retains the feature information captured by each level of features. It is shown experimentally that our proposed method performs better on existing glass detection datasets than several state-of-the-art glass detection and transparent object detection methods, which fully demonstrates the better performance of our TGSNet.
Notes on the Localization of Generalized Hexagonal Cellular Networks
Authors: Azeem Muhammad , Jamil Muhammad Kamran , Shang Yilun
Published: February 2023

The act of accessing the exact location, or position, of a node in a network is known as the localization of a network. In this methodology, the precise location of each node within a network can be made in the terms of certain chosen nodes in a subset. This subset is known as the locating set and its minimum cardinality is called the locating number of a network. The generalized hexagonal cellular network is a novel structure for the planning and analysis of a network. In this work, we considered conducting the localization of a generalized hexagonal cellular network. Moreover, we determined and proved the exact locating number for this network. Furthermore, in this technique, each node of a generalized hexagonal cellular network can be accessed uniquely. Lastly, we also discussed the generalized version of the locating set and locating number.
A Continuous Process for Validation, Verification, and Accreditation of Simulation Models
Authors: Fonseca i Casas Pau
Published: February 2023

A simulation model, and more generically, a model, is founded on its assumptions. Assurance of the model’s correctness and correct use is needed to achieve accreditation. Often the exercise of working with a specific code misunderstands the overall process, focusing the resources on the model coding and forgetting the needed resources to ensure the validation of every step of the model definition and coding. The goal of this work is to present a methodology to help in the definition and use of the assumptions in the modeling process. To do so, we present a process to conduct a simulation project, an assumptions taxonomy, and a method that simplifies working with those assumptions. We propose to extend the traditional Validation, Verification, and Accreditation processes to a process composed of eight Validation, Verification, and Accreditation phases that cover the overall life cycle of a model. Although this paper is focused on a simulation model, we can extend the proposed method to a more general modeling approach.
A Spanning Union of Cycles in Thin Cylinder, Torus and Klein Bottle Grid Graphs
Authors: Đokić Jelena , Doroslovački Ksenija , Bodroža-Pantić Olga
Published: February 2023

In this paper, we propose an algorithm for obtaining the common transfer digraph Dm* for enumeration of 2-factors in graphs from the title, all of which have m·n vertices (m,n∈N,m≥2). The numerical data gathered for m≤18 reveal some matches for the numbers of 2-factors for different types of torus or Klein bottle. In the latter case, we conjecture that these numbers are invariant under twisting.
A Literature Review of Railway Pricing Based on Revenue Management
Authors: Guan Xueyi , Qin Jin , Mao Chenghui , Zhou Wenliang
Published: February 2023

In recent decades, railway passenger transport enterprises have been exploring numerous operation and management strategies to improve service quality and market competitiveness of railway passenger transport so as to ensure that the interests of railway passenger transport enterprises are maximized when taking social welfare into account. However, there are still shortcomings in the current research with respect to determining the pricing mechanism and formulating a reasonable price. This paper systematically reviews the scientific literature related to railway pricing, focusing on the application of basic price methods, mathematical programming methods, and data-driven methods in railway pricing, with the hope of proposing an innovative direction to solve existing problems. The main subjects involved in the formulation of railway pricing are passenger groups and transportation companies. The research can be conducted from four broad aspects: passenger demand, passenger time value, market segmentation, and the equilibrium relationship between rail service supply and passenger demand. On the basis of absorbing and summarizing the strengths and weaknesses of previous studies, this paper puts forward suggestions for improvement and innovative directions which will help promote railway passenger transport services from the perspective of pricing, thereby enhancing the sustainability of railway transport.