bluuebunny/crossref_metadata_2025 huggingface dataset:
Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation
Authors: Horváth Ádám , Payrits Maja , Steib Anita , Kántás Boglárka , Biró-Süt Tünde , Erostyák János , Makkai Géza , Sághy Éva , Helyes Zsuzsanna , Szőke Éva
Published: January 2021

Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions. Lipid rafts are liquid-ordered plasma membrane microdomains rich in cholesterol, sphingomyelin and gangliosides. We earlier showed that lipid raft disruption inhibits TRPV1 and TRPA1 functions in primary sensory neuronal cultures. Here we investigated the effects of sphingomyelinase (SMase) cleaving membrane sphingomyelin and myriocin (Myr) prohibiting sphingolipid synthesis in mouse pain models of different mechanisms. SMase (50 mU) or Myr (1 mM) pretreatment significantly decreased TRPV1 activation (capsaicin)-induced nocifensive eye-wiping movements by 37 and 41%, respectively. Intraplantar pretreatment by both compounds significantly diminished TRPV1 stimulation (resiniferatoxin)-evoked thermal allodynia developing mainly by peripheral sensitization. SMase (50 mU) also decreased mechanical hyperalgesia related to both peripheral and central sensitizations. SMase (50 mU) significantly reduced TRPA1 activation (formalin)-induced acute nocifensive behaviors by 64% in the second, neurogenic inflammatory phase. Myr, but not SMase altered the plasma membrane polarity related to the cholesterol composition as shown by fluorescence spectroscopy. These are the first in vivo results showing that sphingolipids play a key role in lipid raft integrity around nociceptive TRP channels, their activation and pain sensation. It is concluded that local SMase administration might open novel perspective for analgesic therapy.
Piperazine-Derived α1D/1A Antagonist 1- Benzyl-N- (3-(4- (2-Methoxyphenyl) Piperazine-1-yl) Propyl) -1H- Indole-2- Carboxamide Induces Apoptosis in Benign Prostatic Hyperplasia Independently of α1-Adrenoceptor Blocking
Authors: Xiao Qing , Liu Qi-Meng , Jiang Ru-Chao , Chen Kai-Feng , Zhu Xiang , Ma Lei , Li Wei-Xi , He Fei , Huang Jun-Jun
Published: January 2021

Previous studies have indicated that α1D/1A antagonist naftopidil (NAF) suppresses prostate growth by decreasing cell proliferation without affecting apoptosis and prostate volume in benign prostatic hyperplasia (BPH). A NAF-derived α1D/1A antagonist 1- benzyl-N-(3-(4-(2-methoxyphenyl) piperazine-1-yl) propyl)-1H-indole-2- carboxamide (HJZ-12) has been reported from our laboratory, which exhibits high subtype-selectivity to both α1D- and α1A- AR (47.9- and 19.1- fold, respectively) with respect to a1B-AR in vitro. However, no further study was conducted. In the present study, a pharmacological evaluation of HJZ-12 in BPH was performed on an estrogen/androgen-induced rat BPH model and human BPH-1 cell line. In vivo, HJZ-12 exhibited better performance than NAF in preventing the progression of rat prostatic hyperplasia by not only decreasing prostate weight and proliferation (similar to NAF) but also, shrinking prostate volume and inducing prostate apoptosis (different from NAF). In vitro, HJZ-12 exhibited significant cell viability inhibition and apoptotic induction in BPH-1 cell line, without presenting cell anti-proliferation properties. Intriguingly, the role of HJZ-12 on cell viability and apoptosis was an α1-independent action. Furthermore, RNA-Seq analysis was applied to screen out six anti-apoptotic genes (Bcl-3, B-lymphoma Mo-MLV insertion region 1 [Bmi-1], ITGA2, FGFR3, RRS1, and SGK1). Amongst them, Bmi-1 was involved in the apoptotic induction of HJZ-12 in BPH-1. Overall, HJZ-12 played a remarkable role in preventing the progression of prostatic hyperplasia through α1-independent apoptotic induction, indicating that it will be a multi-target effective candidate for BPH treatment.
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study
Authors: Lin Chien-Hung , Chiu Hsienhsueh Elley , Wu Szu-Ying , Tseng Shih-Ting , Wu Tzu-Chan , Hung Yu-Chiang , Hsu Chung Y. , Chen Hsuan-Ju , Hsu Sheng-Feng , Kuo Chun-En , Hu Wen-Long
Published: January 2021

Objective: Combinations of Chinese herbal products (CHPs) are widely used for Parkinson’s disease (PD) in Taiwan. Thereby, we investigated the use of CHPs in patients with PD.

Methods: This study was a population-based cohort study that analyzed the data of patients with PD from the National Health Insurance Research Database. A total of 9,117 patients were selected from a random sample of one million individuals included in this database. We used multiple logistic regression models to estimate the adjusted odds ratios of the demographic factors and analyzed the formula and single CHPs commonly used for PD.

Results: Traditional Chinese medicine users were more commonly female, younger, of white-collar status, and residents of Central Taiwan. Chaihu-Jia-Longgu-Muli-Tang was the most commonly used formula, followed by Ma-Zi-Ren-Wan and then Shao-Yao-Gan-Cao-Tang. The most commonly used single herb was Uncaria tomentosa (Willd. ex Schult.) DC., followed by Gastrodia elata Blume and then Radix et Rhizoma Rhei (Rheum palmatum L., Rheum tanguticum Maxim. ex Balf., and Rheum officinale Baill.). Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. have shown neuroprotective effects in previous studies, and they have been used for managing non-motor symptoms of PD.

Conclusion: Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. are the most commonly used CHPs for PD in Taiwan. Our results revealed the preferences in medication prescriptions for PD. Further studies are warranted to determine the effectiveness of these CHPs for ameliorating the various symptoms of PD, their adverse effects, and the mechanisms underlying their associated neuroprotective effects.
Extracellular ATP Mediates Cancer Cell Migration and Invasion Through Increased Expression of Cyclooxygenase 2
Authors: Sharma Shilpa , Kalra Harshit , Akundi Ravi Shankar
Published: January 2021

The tumor microenvironment plays a major role in the ability of the tumor cells to undergo metastasis. A major player of tumors gaining metastatic property is the inflammatory protein, cyclooxygenase 2 (COX-2). Several tumors show upregulation of this protein, which has been implicated in mediating metastasis in various cancer types such as of colon, breast and lung. In this report, we show that the concentration of extracellular ATP (eATP) is increased in response to cell death mediated by chemotherapeutic agents such as doxorubicin. By using three different cell-lines—HeLa (cervical), IMR-32 (neuronal) and MCF-7 (breast)—we show that this eATP goes on to act on purinergic (P2) receptors. Among the various P2 receptors expressed in these cells we identified P2X7, in IMR-32 and MCF-7 cells, and P2Y12, in HeLa cells, as important in modulating cell migration and invasion. Downstream of the P2 receptor activation, both p42/44 mitogen-activated protein kinase (MAPK) and the p38 MAPK are activated in these cells. These result in an increase in the expression of COX-2 mRNA and protein. We also observe an increase in the activity of matrix metalloproteinase 2 (MMP-2) enzyme in these cells. Blocking the P2 receptors not only blocks migration and invasion, but also COX-2 synthesis and MMP-2 activity. Our results show the link between purinergic receptors and COX-2 expression. Increased levels of ATP in the tumor microenvironment, therefore, leads to increased COX-2 expression, which, in turn, affords migratory and invasive properties to the tumor. This provides P2 receptor-based anti-inflammatory drugs (PBAIDs) a potential opportunity to be explored as cancer therapeutics.
Systemic Administration of Fibroblast Growth Factor 21 Improves the Recovery of Spinal Cord Injury (SCI) in Rats and Attenuates SCI-Induced Autophagy
Authors: Zhu Sipin , Ying Yibo , Ye Lin , Ying Weiyang , Ye Jiahui , Wu Qiuji , Chen Min , Zhu Hui , Li Xiaoyang , Dou Haicheng , Xu Huazi , Wang Zhouguang , Xu Jiake
Published: January 2021

Protecting the death of nerve cells is an essential tactic for spinal cord injury (SCI) repair. Recent studies show that nerve growth factors can reduce the death of nerve cells and promote the healing of nerve injury. To investigate the conducive effect of fibroblast growth factor 21 (FGF21) on SCI repair. FGF21 proteins were systemically delivered into rat model of SCI via tail vein injection. We found that administration of FGF21 significantly promoted the functional recovery of SCI as assessed by BBB scale and inclined plane test, and attenuated cell death in the injured area by histopathological examination with Nissl staining. This was accompanied with increased expression of NeuN, GAP43 and NF200, and deceased expression of GFAP. Interestingly, FGF21 was found to attenuate the elevated expression level of the autophagy marker LC3-II (microtubules associated protein 1 light chain 3-II) induced by SCI in a dose-dependent manner. These data show that FGF21 promotes the functional recovery of SCI via restraining injury-induced cell autophagy, suggesting that systemic administration of FGF21 could have a therapeutic potential for SCI repair.
Synthesis, Anti-Tumor Activity and Apoptosis-Inducing Effect of Novel Dimeric Keggin-Type Phosphotungstate
Authors: Xue Yingxue , Yin Yifei , Li He , Chi Mingyu , Guo Jiaxin , Cui Guihua , Li Wenliang
Published: January 2021

A dimeric Keggin-type phosphotungstate (ODA)10[(PW11FeO39)2O]·9H2O (abbreviated as ODA10[(PW11Fe)2], ODA = octadecyltrimethylammonium bromide) was synthesized and investigated comprehensively its antitumor activity on MCF-7 and A549 cells. The dimeric structure and amorphous morphology were characterized by FT-IR, UV-vis-DRS, SEM and XRD. The in vitro MTT assay of ODA10[(PW11Fe)2] showed anticancer activity on MCF-7 and A549 cells in a dose- and time-dependent manner, and the IC50 values for MCF-7 and A549 cells at 48 h were 5.83 μg/ml and 3.23 μg/ml, respectively. The images of the ODA10[(PW11Fe)2]-treated cells observed by inverted biological microscope exhibited the characteristic morphology of apoptosis. Flow cytometric analysis showed cell apoptosis and cycle arrested at S phase induced by ODA10[(PW11Fe)2]. The above results illuminated the main mechanism of the antitumor action of ODA10[(PW11Fe)2] on MCF-7 and A549 cells, indicating that this dimeric phosphotungstate is a promising anticancer drug.
Realization of Accurate Load Impedance Characterization for On-Wafer TRM Calibration
Authors: Su Jiangtao , Wang Jianhua , Wang Fei , Sun Lingling
Published: January 2021

In this paper, the uncertainty and the impact of imperfect load calibration standard for on-wafer Through-Reflect-Match calibration method are analyzed with the help of 3D electromagnetic simulations. Based on the finding that load impedance can lead to significant errors in calibration, an automatic algorithm to determine the complex impedance of the load standard is proposed. This method evaluates the resistance as well as the parasitic inductance introduced by the misalignment of the probe tip to the substrate pad at mm-wave frequencies or the non-precize load standard. The proposed algorithm was verified by practical measurement, and the results show that by incorporating actual load impedance into the calibration algorithm, the deviations of RF measurement results are greatly suppressed.
Properties and Use of Water Activated by Plasma of Piezoelectric Direct Discharge
Authors: Konchekov Evgeny M. , Glinushkin Alexey P. , Kalinitchenko Valery P. , Artem’ev Konstantin V. , Burmistrov Dmitry E. , Kozlov Valery A , Kolik Leonid V.
Published: January 2021

The distilled water was exposed to a cold atmospheric plasma (CAP) generated by the piezotransformer. The treatment was carried out on a six-well plate. Exposure time was from 30 s to 10 min. The emission spectra were obtained. Physical and chemical changes of activated water were observed for 8 days. The reactive oxygen and nitrogen species (RONS) were investigated. RONS production dependence on the exposure time and RONS lifetime in the treated liquid was determined using absorbance spectra. Quantitative assessment was made of the nitrite and nitrate concentration change over time after treatment. The medium conductivity and redox potential varied linearly depending on exposure time. The pH value change correlates with nitrate anion concentration. The concentration of peroxide hydrogen increased depending on CAP water treatment duration. The RONS concentration after liquid media processing with piezoelectric direct discharge CAP is a novel result. Biogeosystem Technique provides CAP activated water agriculture synergetic effect.
The ECG Characteristics of Patients With Isolated Hypomagnesemia
Authors: Yang Yiheng , Chen Cheng , Duan Penghong , Thapaliya Suman , Gao Lianjun , Dong Yingxue , Yin Xiaomeng , Yang Xiaolei , Zhang Rongfeng , Tan Ruopeng , Hui Simei , Wang Yue , Sutton Richard , Xia Yunlong
Published: January 2021

Background

Electrocardiographic (ECG) characteristics of patients with isolated hypomagnesemia are not well defined. We aimed to investigate these ECG characteristics in order to define clearly the features of isolated hypomagnesemia.

Hypothesis

Lower serum magnesium could affect ECG parameters after excluding potential confounders.

Methods

This retrospective study was of patients with low serum magnesium <0.65 mmol/L compared with the same patients after restoration to normal serum magnesium. Patients with hypokalemia, hypocalcemia and other electrolyte disturbances were excluded. ECG parameters manually determined and analyzed were P wave dispersion, PR interval, QRS duration, ST-T changes, T wave amplitude, T peak-to-end interval (Tpe), corrected Tpe (Tpec), QT, corrected QT (QTc), QT peak corrected (QTpc) and Tpe dispersion, Tpe/QT ratio.

Results

Two-hundred-and-fourteen patients with isolated hypomagnesemia were identified with 50 of them (56.9 ± 13.6 years; 25 males) being eligible for final analysis from 270,997 patients presenting April 2011–October 2017. In the period of isolated hypomagnesemia, P wave duration was found prolonged (p ≤ 0.02); as was QTc (439 ± 27 vs. 433 ± 22, p = 0.01). Tpec (122 ± 24vs. 111 ± 22, p = 0.000) and Tpe/QT ratio (0.29 ± 0.05 vs. 0.27 ± 0.05, p = 0.000) were increased. QTpc decreased during hypomagnesemia (334 ± 28 vs. 342 ± 21, p = 0.02). However, no significant differences were found in PR interval, QRS duration (85 ± 12 ms vs. 86 ± 12 ms, p = 0.122) and ST-T segments between the patients and their own controls.

Conclusions

In patients with isolated hypomagnesemia, P wave duration, QTc, Tpec, and Tpe/QT ratio suggesting atrial depolarization and ventricular repolarization dispersion were significantly increased compared with normal magnesium levels in the same patients after restoration to normal levels.
From Congenital Disorders of Fat Malabsorption to Understanding Intra-Enterocyte Mechanisms Behind Chylomicron Assembly and Secretion
Authors: Levy Emile , Beaulieu Jean François , Spahis Schohraya
Published: January 2021

During the last two decades, a large body of information on the events responsible for intestinal fat digestion and absorption has been accumulated. In particular, many groups have extensively focused on the absorptive phase in order to highlight the critical “players” and the main mechanisms orchestrating the assembly and secretion of chylomicrons (CM) as essential vehicles of alimentary lipids. The major aim of this article is to review understanding derived from basic science and clinical conditions associated with impaired packaging and export of CM. We have particularly insisted on inborn metabolic pathways in humans as well as on genetically modified animal models (recapitulating pathological features). The ultimate goal of this approach is that “experiments of nature” and in vivo model strategy collectively allow gaining novel mechanistic insight and filling the gap between the underlying genetic defect and the apparent clinical phenotype. Thus, uncovering the cause of disease contributes not only to understanding normal physiologic pathway, but also to capturing disorder onset, progression, treatment and prognosis.
Changes in the Concentration of Purine and Pyridine as a Response to Single Whole-Body Cryostimulation
Authors: Dudzinska Wioleta , Lubkowska Anna
Published: January 2021

To our knowledge, this is the first study in which we provide evidence that a single whole-body cryostimulation treatment leads to changes associated with erythrocyte energy metabolism. These changes are beneficial from the point of view of cellular bioenergetics, because they are associated with an increase in ATP concentration and erythrocyte energy potential expressed by an increase in the ATP/ADP and ATP/AMP ratios and the value of adenylate energy charge (AEC). In addition, as affected by cryogenic temperatures, there is a decrease in the concentration of purine catabolism products, i.e., inosine and hypoxanthine in the blood.
Seed Yield and Nitrogen Efficiency in Oilseed Rape After Ammonium Nitrate or Urea Fertilization
Authors: Heuermann Diana , Hahn Heike , von Wirén Nicolaus
Published: January 2021

In agricultural plant production, nitrate, ammonium, and urea are the major fertilized nitrogen forms, which differ in root uptake and downstream signaling processes in plants. Nitrate is known to stimulate cytokinin synthesis in roots, while for urea no hormonal effect has been described yet. Elevated cytokinin levels can delay plant senescence favoring prolonged nitrogen uptake. As the cultivation of winter oilseed rape provokes high nitrogen-balance surpluses, we tested the hypotheses whether nitrogen use efficiency increases under ammonium nitrate- relative to urea-based nutrition and whether this is subject to genotypic variation. In a 2-year field study, 15 oilseed rape lines were fertilized either with ammonium nitrate or with urease inhibitor-stabilized urea and analyzed for seed yield and nitrogen-related yield parameters. Despite a significant environmental impact on the performance of the individual lines, which did not allow revealing consistent impact of the genotype, ammonium nitrate-based nutrition tended to increase seed yield in average over all lines. To resolve whether the fertilizer N forms act on grain yield via phytohormones, we collected xylem exudates at three developmental stages and determined the translocation rates of cytokinins and N forms. Relative to urea, ammonium nitrate-based nutrition enhanced the translocation of nitrate or total nitrogen together with cytokinins, whereas in the urea treatment translocation rates were lower as long as urea remained stable in the soil solution. At later developmental stages, i.e., when urea became hydrolyzed, nitrogen and cytokinin translocation increased. In consequence, urea tended to increase nitrogen partitioning in the shoot toward generative organs. However, differences in overall nitrogen accumulation in shoots were not present at the end of the vegetation period, and neither nitrogen uptake nor utilization efficiency was consistently different between the two applied nitrogen forms.
A Multi-Species Analysis Defines Anaplerotic Enzymes and Amides as Metabolic Markers for Ammonium Nutrition
Authors: González-Moro María Begoña , González-Moro Itziar , de la Peña Marlon , Estavillo José María , Aparicio-Tejo Pedro M. , Marino Daniel , González-Murua Carmen , Vega-Mas Izargi
Published: January 2021

Nitrate and ammonium are the main nitrogen sources in agricultural soils. In the last decade, ammonium (NH4+), a double-sided metabolite, has attracted considerable attention by researchers. Its ubiquitous presence in plant metabolism and its metabolic energy economy for being assimilated contrast with its toxicity when present in high amounts in the external medium. Plant species can adopt different strategies to maintain NH4+ homeostasis, as the maximization of its compartmentalization and assimilation in organic compounds, primarily as amino acids and proteins. In the present study, we report an integrative metabolic response to ammonium nutrition of seven plant species, belonging to four different families: Gramineae (ryegrass, wheat, Brachypodium distachyon), Leguminosae (clover), Solanaceae (tomato), and Brassicaceae (oilseed rape, Arabidopsis thaliana). We use principal component analysis (PCA) and correlations among metabolic and biochemical data from 40 experimental conditions to understand the whole-plant response. The nature of main amino acids is analyzed among species, under the hypothesis that those Asn-accumulating species will show a better response to ammonium nutrition. Given the provision of carbon (C) skeletons is crucial for promotion of the nitrogen assimilation, the role of different anaplerotic enzymes is discussed in relation to ammonium nutrition at a whole-plant level. Among these enzymes, isocitrate dehydrogenase (ICDH) shows to be a good candidate to increase nitrogen assimilation in plants. Overall, metabolic adaptation of different carbon anaplerotic activities is linked with the preference to synthesize Asn or Gln in their organs. Lastly, glutamate dehydrogenase (GDH) reveals as an important enzyme to surpass C limitation during ammonium assimilation in roots, with a disparate collaboration of glutamine synthetase (GS).
Navigating Motivation: A Semantic and Subjective Atlas of 7 Motives
Authors: Chierchia Gabriele , Przyrembel Marisa , Lesemann Franca Parianen , Bosworth Steven , Snower Dennis , Singer Tania
Published: January 2021

Research from psychology, neurobiology and behavioral economics indicates that a binary view of motivation, based on approach and avoidance, may be too reductive. Instead, a literature review suggests that at least seven distinct motives are likely to affect human decisions: “consumption/resource seeking,” “care,” “affiliation,” “achievement,” “status-power,” “threat approach” (or anger), and “threat avoidance” (or fear). To explore the conceptual distinctness and relatedness of these motives, we conducted a semantic categorization task. Here, participants were to assign provided words to one of the motives. By applying principal component analysis to the categorization assignments we represent the semantic inter-relations of these motives on a two-dimensional space, a “semantic atlas.” This atlas suggests that, while care and affiliation are conceptually close, affiliation is closer to threat avoidance (or fear); opposite to these motives we find achievement, consumption and power, with the latter lying closer to threat approach (or anger). In a second study, we asked participants to rate how well the motive-specific words obtained in the first study described their currently experienced feelings. We find that semantically close motives are also more likely to be experienced together, that is, we replicate most of the semantic relations in the “subjective atlas.” We discuss our findings in comparison to other multi-dimensional models of motivation, which show clear similarities. In addition to these motivational atlases, we provide a database of motive-specific words, together with the valence and arousal scores. These can be used for future research on the influence of motives on decision making.
Exploring the Social and Emotional Representations Used by the Elderly to Deal With the COVID-19 Pandemic
Authors: Eiguren Amaia , Idoiaga Nahia , Berasategi Naiara , Picaza Maitane
Published: January 2021

Spain has become one of the European epicenters of coronavirus (COVID-19), a virus that particularly affects the elderly, since this group accounts for the majority of hospitalized cases and has the highest mortality rates. Therefore, the aim of this research is to understand how elderly people represent and emotionally cope with COVID-19 during the days when the pandemic emerged in Spain. Using a qualitative methodology, a free association exercise elicited by the word “COVID-19” was completed by 115 participants (age range: 60–85 years) from the North of Spain. Lexical analysis was used to analyze the content. The results revealed that the government and the mass media are criticized for failing to communicate a clear message, and for giving out information that is both insufficient and contradictory. However, participants are clear that it is essential to follow the guidelines of the scientists and doctors, which are represented as credible sources. However, when the state of alarm and the lockdown of all citizens was declared, most of the participants represented the risk as being associated with the elderly and the pandemic became something that might also affect their families. Due to these circumstances, negative emotions appear such as fear, nervousness, uncertainty, restlessness, and insecurity. Feelings of solitude and loneliness also emerged, and these are represented as being linked to death. These results indicate the need for governments to manage the current situation with the elderly by placing greater emphasis on social and inclusive policies to help alleviate the possible effects of the pandemic and the lockdown.
COVID-19 and Pretentious Psychological Well-Being of Students: A Threat to Educational Sustainability
Authors: Li Hui , Hafeez Hira , Zaheer Muhammad Asif
Published: January 2021

Since the outbreak of COVID-19, reaction quarantine, social distancing, and economic crises have posed a greater risk to physical and psychological health. Such derogatory mental health stigma is associated with adverse outcomes in the student population. The purpose of the current study is to provide a timely evaluation of the COVID-19 pandemic and its adverse effects on students’ psychological well-being to sustain economic sustainability. A thorough review of the literature and current studies, significant emphasis of socio-demographic indicators, interpretation of physical symptoms, home quarantine activities, and COVID-19 unique stressors were extracted. Data were collected through electronic surveys from 640 university students at local and foreign universities. The findings revealed substantial adverse effects resulting in varying levels of stress, symptoms of depression, and specific discomfort in the case. Among COVID-19 stressors, financial instability, unpredictability toward future/career, and media exposure have been described as common factors that cause poor psychological well-being and weaken economic sustainability. COVID-19, quarantine, self-isolation, and onerous interventions primarily weaken university students’ mental health. The emphasis on this vulnerable category, however, is substantially absent from the literature. This research addresses the urgent need to develop possible solutions and preventive measures to promote economic sustainability by ensuring students’ psychological well-being.
The Limits of Resilience and the Need for Resistance: Articulating the Role of Music Therapy With Young People Within a Shifting Trauma Paradigm
Authors: Scrine Elly
Published: January 2021

A broad sociocultural perspective defines trauma as the result of an event, a series of events, or a set of circumstances that is experienced as physically or emotionally harmful or life threatening, with lasting impacts on an individual’s physical, social, emotional, or spiritual wellbeing. Contexts and practices that aim to be “trauma-informed” strive to attend to the complex impacts of trauma, integrating knowledge into policies and practices, and providing a sanctuary from harm. However, there is a body of critical and decolonial scholarship that challenges the ways in which “trauma-informed” practice prioritizes individualized interventions, reinscribes colonial power relations through its conceptualizations of safety, and obscures the role of systemic injustices. Within music therapy trauma scholarship, research has thus far pointed to the affordances of music in ameliorating symptoms of trauma, bypassing unavailable cognitive processes, and working from a strengths-based orientation. In critiquing the tendency of the dominant trauma paradigm to assign vulnerability and reinforce the individual’s responsibility to develop resilience through adversity, this conceptual analysis outlines potential alternatives within music therapy. Drawing on a case example from a research project with young people in school, I elucidate the ways in which music therapy can respond to power relations as they occur within and beyond “trauma-informed” spaces. I highlight two overarching potentials for music therapy within a shifting trauma paradigm: (1) as a site in which to reframe perceived risk by fostering young people’s resistance and building their political agency and (2) in challenging the assumption of “safe spaces” and instead moving toward practices of “structuring safety.”
Study of the SCL-90 Scale and Changes in the Chinese Norms
Authors: Dang Weimin , Xu Yajuan , Ji Jun , Wang Ke , Zhao Songtao , Yu Bin , Liu Jinming , Feng Chaonan , Yu Haokui , Wang Wenqiang , Yu Xin , Dong Wentian , Ma Yantao
Published: January 2021

Objective: This study aimed to investigate the Chinese norms for the Symptom Checklist 90 (SCL-90) scale and its application.

Methods: In total, 7,489 adults from Tianjin and Qingdao in China were included. Their data were compared with the norm data of 1,388 people published by Jin et al., the combined norms published by Tang et al., the data of 2,808 adults published by Chen and Li, and the data of 1,890 adults from Tong in China.

Results: In five different periods, notable changes were observed in each factor of the SCL-90 that significantly differed from the previous norms. The scores of each factor showed an increasing annual trend. Compulsion consistently obtained the highest scores, and phobia consistently obtained the lowest scores. The scores tended to decrease from compulsion to anxiety, and psychosis scored lower than paranoia. There was a significant difference in the detection rate between the critical screening value of two points and the standard score. Using the standard score as the critical value, the detection rate ranged between 13 and 16% and was relatively concentrated. Using two points as the critical value, the detection rate ranged between 38 and 50%.

Conclusion: The usual model in China is not consistent with social development. Using two points as the critical value is no longer suitable for the SCL-90. New Chinese norms and measurement standards should be developed. The mean value plus one standard deviation could be used as the new measurement standard.
Demand Analysis of a Psychiatric Emergency Room and an Adolescent Acute Inpatient Unit in the Context of the COVID-19 Pandemic in Madrid, Spain
Authors: Díaz de Neira Mónica , Blasco-Fontecilla Hilario , García Murillo Lourdes , Pérez-Balaguer Ana , Mallol Leticia , Forti Azul , Del Sol Pablo , Palanca Inmaculada
Published: January 2021

Introduction: COVID-19 represents a serious threat to mental health worldwide. The aim of this study is to identify changes in adolescent psychiatry treatment demand in a tertiary hospital in Madrid during the first month (March 11 to April 11) after the pandemic declaration by the World Health Organization (WHO). We hypothesized that fear of contagion within COVID-19 may deter people from asking for psychiatric care.

Method: The current study is retrospective, observational, and transversal. We reviewed the clinical records of 89 adolescents who went to the Emergency Room (ER) or were hospitalized at the Acute Inpatient Unit (AIU) at the Puerta de Hierro University Hospital-Majadahonda (PHUH-M) between March 11 and April 11. Socio-demographic, clinical, and demand variables were included in the study. Chi-square or Fisher exact tests were performed to compare categorical variables. We used the U Mann-Whitney test to compare quantitative variables. The level of statistical significance was set at p< 0.05. Analyses were conducted using SPSS v11.0.

Results: The number of adolescents demanding psychiatric care at the ER dropped from 64 adolescents in 2019 to 25 in 2020. Similarly, psychiatric demand collapsed from 31 to 18 patients when comparing 2019 and 2020. Furthermore, the average hospital stay in 2020 trended toward a decrease when compared to 2019 (8.94 ± 4.87 vs. 14.32 ±10.23, p = 0.08). Self-injurious thoughts and behaviors were the most predominant reasons for consultation at both ER and AIU.

Conclusion: The demand for adolescent psychiatric care decreased in the first month after the declaration of the pandemic. Our findings may be explained by (1) the fear of contagion, (2) the strict confinement measures, and (3) the initial shock as an adaptive reaction described in other disasters. Further studies are needed.
Challenges of Psychiatry Drug Development and the Role of Human Pharmacology Models in Early Development—A Drug Developer's Perspective
Authors: Zhu Tong
Published: January 2021

Psychiatric diseases have the lowest probability of success in clinical drug development. This presents not only an issue to address the unmet medical needs of patients, but also a hurdle for pharmaceutical and biotech industry to continue R&D in this disease area. Fundamental pharmacokinetic and pharmacodynamic principles provide an understanding of the drug exposure, target binding and pharmacological activity at the target site of action for a new drug candidate. Collectively, these principles determine the likelihood of testing the mechanism of action and enhancing the likelihood of candidate survival in Phase 2 clinical development, therefore, they are termed as the “three pillars of survival.” Human Phase 1 pharmacokinetic and pharmacodynamic studies provide evidence of the three pillars. Electroencephalogram (EEG) assessments and cognitive function tests in schizophrenia patients can provide proof of pharmacology and ensure that a pharmacological active regimen will be tested in Phase 2 proof of concept (POC) studies for the treatment of cognitive impairment associated with schizophrenia (CIAS).
Using Health Insurance Network Provider Data and Public Data Sets to Identify SARS-CoV-2 Vaccinators in the USA
Authors: Litaker John R. , Tamez Naomi , Durkalski Wesley , Taylor Richard
Published: January 2021

Objective: Mass vaccination planning is occurring at all levels of government in advance of regulatory approval and manufacture of a SARS-CoV-2 vaccine for distribution sometime in 2021. We outline a methodology in which both health insurance provider network data and publicly available data sources can be used to identify and plan for SARS-CoV-2 vaccinator capacity at the county level.

Methods: Sendero Health Plans, Inc. provider network data, Texas State Board of Pharmacy data, US Census Bureau data, and H1N1 monovalent vaccine data were utilized to identify providers with demonstrated capacity to vaccinate the population in Travis County, Texas to achieve an estimated SARS-CoV-2 herd immunity target of 67%.

Results: Within the Sendero network, 2,356 non-pharmacy providers were identified with 788 (33.4%) practicing in primary care and 1,569 (66.6%) practicing as specialists. Of the total, 686 (29.1%) provided at least one immunization between January 1, 2019 and September 30, 2020. There are 300 pharmacies with active licenses in Travis County with 161 (53.7%) classified as community pharmacies. We estimate that 1,707,098 doses of a 2-dose SARS-CoV-2 vaccine series will need to be administered within Travis County, Texas to achieve the estimated 67% herd immunity threshold to disrupt person-to-person transmission of the SARS-CoV-2 virus based on 2020 census data.

Conclusion: A community-based health insurance plan can use data from its provider network and public data sources to support the CDC call to action to identify SARS-CoV-2 vaccinators in the community, including physicians, nurse practitioners, physician assistants, and pharmacies in order to provide macro level estimates of SARS-CoV-2 administration and throughput.
Opportunities and Challenges for Artificial Intelligence Applications in Infrastructure Management During the Anthropocene
Authors: Markolf Samuel A. , Chester Mikhail V. , Allenby Braden
Published: January 2021

Pervasive and accelerating climatic, technological, social, economic, and institutional change dictate that the challenges of the future will likely be vastly different and more complex than they are today. As our infrastructure systems (and their surrounding environment) become increasingly complex and beyond the cognitive understanding of any group of individuals or institutions, artificial intelligence (AI) may offer critical cognitive insights to ensure that systems adapt, services continue to be provided, and needs continue to be met. This paper conceptually links AI to various tasks and leadership capabilities in order to critically examine potential roles that AI can play in the management and implementation of infrastructure systems under growing complexity and uncertainty. Ultimately, various AI techniques appear to be increasingly well-suited to make sense of and operate under both stable (predictable) and chaotic (unpredictable) conditions. The ability to dynamically and continuously shift between stable and chaotic conditions is critical for effectively navigating our complex world. Thus, moving forward, a key adaptation for engineers will be to place increasing emphasis on creating the structural, financial, and knowledge conditions for enabling this type of flexibility in our integrated human-AI-infrastructure systems. Ultimately, as AI systems continue to evolve and become further embedded in our infrastructure systems, we may be implicitly or explicitly releasing control to algorithms. The potential benefits of this arrangement may outweigh the drawbacks. However, it is important to have open and candid discussions about the potential implications of this shift and whether or not those implications are desirable.
Combined Pressure Sensor With Enhanced Dynamic Range Based on Thin Films of Nanotubes and Graphite Nanobelts
Authors: Alaferdov Andrei , Vilkov Ilya , Kaverin Boris , Ob´edkov Anatoly , Moshkalev Stanislav
Published: January 2021

Herein, we demonstrate the prototype of a combined flexible pressure sensor based on ultrathin multiwall carbon nanotubes (MWCNTs) and graphite nanobelts (GNBs) films embedded in polydimethylsiloxane (PDMS). A simple and scalable modified Langmuir–Blodgett method was used for deposition of both MWCNT and GNB films. The use of two types of carbon nanostructures (nanotubes and GNBs) with distinctly different mechanical properties allowed obtaining enhanced dynamic range for pressure sensing. Short response time, good sensibility and flexibility, and low power consumption for enhanced pressure range make possible applications of the sensor for healthcare monitoring and as a component in the human–machine interfaces application.
Intravenous and Oral Fluid Therapy in Neonatal Calves With Diarrhea or Sepsis and in Adult Cattle
Authors: Constable Peter D. , Trefz Florian M. , Sen Ismail , Berchtold Joachim , Nouri Mohammad , Smith Geoffrey , Grünberg Walter
Published: January 2021

Optimal fluid therapy protocols in neonatal calves and adult cattle are based on consideration of signalment, history, and physical examination findings, and individually tailored whenever laboratory analysis is available. Measurement of the magnitude of eye recession, duration of skin tenting in the lateral neck region, and urine specific gravity by refractometry provide the best estimates of hydration status in calves and cattle. Intravenous and oral electrolyte solutions (OES) are frequently administered to critically ill calves and adult cattle. Application of physicochemical principles indicates that 0.9% NaCl, Ringer's solution, and 5% dextrose are equally acidifying, lactated Ringer's and acetated Ringer's solution are neutral to mildly acidifying, and 1.3–1.4% sodium bicarbonate solutions are strongly alkalinizing in cattle. Four different crystalloid solutions are recommended for intravenous fluid therapy in dehydrated or septic calves and dehydrated adult cattle: (1) lactated Ringer's solution and acetated Ringer's solution for dehydrated calves, although neither solution is optimized for administration to neonatal calves or adult cattle; (2) isotonic (1.3%) or hypertonic (5.0 or 8.4%) solutions of sodium bicarbonate for the treatment of calves with diarrhea and severe strong ion (metabolic) acidosis and hyponatremia, and adult cattle with acute ruminal acidosis; (3) Ringer's solution for the treatment of metabolic alkalosis in dehydrated adult cattle, particularly lactating dairy cattle; and (4) hypertonic NaCl solutions (7.2%) and an oral electrolyte solution or water load for the rapid resuscitation of dehydrated neonatal calves and adult cattle. Much progress has been made since the 1970's in identifying important attributes of an OES for diarrheic calves. Important components of an OES for neonatal calves are osmolality, sodium concentration, the effective SID that reflects the concentration of alkalinizing agents, and the energy content. The last three factors are intimately tied to the OES osmolality and the abomasal emptying rate, and therefore the rate of sodium delivery to the small intestine and ultimately the rate of resuscitation. An important need in fluid and electrolyte therapy for adult ruminants is formulation of a practical, effective, and inexpensive OES.
A Multi-Objective Optimization Method for Hospital Admission Problem—A Case Study on Covid-19 Patients
Authors: AbdelAziz Amr Mohamed , Alarabi Louai , Basalamah Saleh , Hendawi Abdeltawab
Published: January 2021

The wide spread of Covid-19 has led to infecting a huge number of patients, simultaneously. This resulted in a massive number of requests for medical care, at the same time. During the first wave of Covid-19, many people were not able to get admitted to appropriate hospitals because of the immense number of patients. Admitting patients to suitable hospitals can decrease the in-bed time of patients, which can lead to saving many lives. Also, optimizing the admission process can minimize the waiting time for medical care, which can save the lives of severe cases. The admission process needs to consider two main criteria: the admission time and the readiness of the hospital that will accept the patients. These two objectives convert the admission problem into a Multi-Objective Problem (MOP). Pareto Optimization (PO) is a common multi-objective optimization method that has been applied to different MOPs and showed its ability to solve them. In this paper, a PO-based algorithm is proposed to deal with admitting Covid-19 patients to hospitals. The method uses PO to vary among hospitals to choose the most suitable hospital for the patient with the least admission time. The method also considers patients with severe cases by admitting them to hospitals with the least admission time regardless of their readiness. The method has been tested over a real-life dataset that consisted of 254 patients obtained from King Faisal specialist hospital in Saudi Arabia. The method was compared with the lexicographic multi-objective optimization method regarding admission time and accuracy. The proposed method showed its superiority over the lexicographic method regarding the two criteria, which makes it a good candidate for real-life admission systems.
Modern Semi-Active Control Schemes for a Suspension with MR Actuator for Vibration Attenuation
Authors: Floreán-Aquino Kevin Herubiel , Arias-Montiel Manuel , Linares-Flores Jesús , Mendoza-Larios José Gabriel , Cabrera-Amado Álvaro
Published: January 2021

This article describes semi-active modern control schemes for a quarter-vehicle suspension with a magnetorheological damper (MRD) to attenuate vibrations and simultaneously improve the passenger comfort and the vehicle road-holding. The first solution is a multiple positive position feedback (MPPF) control scheme to attenuate the vibration amplitude at the two modal frequencies. The second solution is based on elementary passivity considerations on the exact regulation error dynamics passive output. The passive output feedback is used to improve the control aims. Finally, the third solution deals with a disturbance rejection control (DRC) based on an extended state observer. The three proposed control schemes consider an inverse polynomial model of a commercial MRD for numerical implementation and are evaluated by comfort and road-holding performance indexes proposed in the literature. Furthermore, the effects of variation in the sprung mass (emulating different number of passengers) on the controllers’ performance is analysed. The numerical results show in both scenarios (constant and variable sprung mass) that passivity based control (PBC) and DRC improve the performance indexes compared with the classical sky-hook control and the open-loop systems with a different constant current input for the MRD. Obtained results for damping force and power consumption are within the operation range of the considered commercial MRD showing the viability for experimental implementation of the proposed control schemes.
Actuator Fault Tolerant Control of Variable Cycle Engine Using Sliding Mode Control Scheme
Authors: Yuan Yuan , Zhang Tianhong , Lin Zhonglin , Zhao Zhiwen , Zhang Xinglong
Published: January 2021

This paper presents a fault tolerant control (FTC) design for the actuator faults in a variable cycle engine (VCE). Ensured by the multiple variable geometries structure of VCE, the design is realized by distributing the control effort among the unfaulty actuators with the “functional redundancy” idea. The FTC design consists of two parts: the fault reconstruction part and the fault tolerant control part, which use a sliding mode observer (SMO) and a sliding mode control (SMC) scheme respectively. Considering the inaccuracy of the fault reconstruction result, the proposed design requires only inaccurate fault information. The stability of the closed-loop control system is proved and the existence condition for the proposed control law is analyzed. This work also reveals its relation to the sliding mode control allocation design and the adaptive SMC design. An application case is then studied for tolerating the loss of effectiveness fault of the nozzle area actuator. Results show that the FTC design is able to tolerate the fault and achieves the same control goal as in the fault-free situation. Finally, a hardware-in-the-loop test is carried out to verify the design in a real-time distributed control system, which demonstrates its use from the engineering perspective.