bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil da saúde bucal, nutricional e cognitiva de idosos
Authors: Chariglione Isabelle Patriciá Freitas Soares , Silva Henrique Salmazo da , Beal Fabiani Leal Rodrigues , Miranda Alexandre Franco
Published: May 2022

O envelhecimento populacional desafia a sociedade em compreensões mais amplas sobre o processo de envelhecer. O objetivo deste estudo foi descrever possíveis associações entre parâmetros de estado nutricional, bucal, psicológico e cognitivo em idosos. Trata-se de uma pesquisa transversal e exploratória que avaliou 15 idosos (M=69 anos; DP=±6,97) residentes na comunidade e participantes de um grupo de intervenções cognitivas. Na análise estatística, optou-se pelo teste Qui-Quadrado para variáveis categóricas e Mann-Whitney ou Kruskal-Wallis para variáveis quantitativas discretas (p≤0,005). Observou-se correlação positiva entre circunferência da panturrilha e desempenho cognitivo global, e correlações negativas entre circunferência de panturrilha e sintomas depressivos, assim como entre qualidade de vida e número de dentes perdidos. Conclui-se destacando a relevância de estudos como estes que avaliam diferentes parâmetros para uma compreensão mais ampla da saúde dos idosos.
Depresión y ansiedad en estudiantes que ingresan a la universidad y factores de estrés asociados
Authors: Londoño Nora Helena , Restrepo Liliana Catalina Calle , Rojas Zulma Berrio
Published: May 2022

Teniendo en cuenta el grupo de población elevado que representan los estudiantes universitarios, se reconoce la importancia de los estudios sobre salud mental realizados en esta población. El presente estudio tuvo como objetivo identificar la prevalencia de la depresión y la ansiedad en estudiantes que ingresan a la Universidad y establecer la relación con el estrés. Metodología: participaron 878 estudiantes (49.5% hombres y 50.5% mujeres), edad media 18.96 (DT 4.2) de tres ciudades de Colombia, entre el 2017 y el 2019, inscritos a psicología, educación, ingenierías, ciencias empresariales, arquitectura y artes integradas y derecho. Los instrumentos utilizados fueron CES-D, SCL-90 y la escala de acontecimientos estresantes. Resultados: la prevalencia de los síntomas de depresión fue del 26.8%; de angustia, 23%; de agorafobia, 7.3%. Los estresores se establecieron como factores de riesgo para la depresión (χ2 = 22.9; p = 0.00; OR = 2.356, intervalo de confianza 95%, 1.651- 3.564), la angustia (χ2 = 55.246; p = 0.00; OR = 5.813, intervalo de confianza 95%, 2.644 - 5.498) y la agorafobia (χ2 = 55.246; p = 0.00; OR = 5.813, intervalo de confianza 95%, 2.644 - 5.498; hombres: χ2 = 24.176; p = 0.00). Conclusión: las cargas de estrés, tanto vital como interpersonal, tienen un peso significativo en la aparición de síntomas de depresión y ansiedad en estudiantes universitarios.
Implementasi Keterampilan Massage Kepada Masyarakat di Kota Banjarbaru
Authors: Rachman Aryadi , Athar Athar
Published: May 2022

Massage merupakan suatu ilmu alami masyarakat yang berkembang dengan pesat, massage sebagai salah satu kelompok pengobatan tradisional. Massage menjadi salah satu alternatif pengobatan yang diandalkan dalam pengobatan beberapa gangguan kesehatan manusia. Mitra dalam pengabdian ini adalah Aqilla’s Massage Therapy, beberapa terapisnya memiliki kekurangan kualitas pemahaman dan kemampuan massage yang ilmiah, hal ini menjadi masalah tersendiri di Aqilla’s Massage Therapy. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan kualitas terapis dengan memberikan metode dan teknik keterampilan massage, baik teori dan praktik, sehingga terapis Aqilla’s Massage Therapy dapat mengimplementasikannya di lapangan. Metode yang digunakan dalam pelaksanaan pengabdian ini yaitu metode ceramah, diskusi dan praktik. Kegiatan ini melibatkan mitra penyedia jasa terapi pijat kebugaran yaitu Aqilla’s Massage Therapy yang berjumlah 9 orang terapis. Hasil pengabdian masyarakat ini adalah menghasilkan terapis berkualitas yang dapat memberikan layanan kepada masyarakat di Kota Banjarbaru, pada tahun 2021 terdapat peningkatan permintaan layanan jasa di Aqilla’s Massage Therapy sebanyak 69%. Massage is a natural science of society that is growing rapidly, massage as a group of traditional medicine. Massage is one of the reliable alternative treatments in the treatment of several human health disorders. The partner in this service is Aqilla's Massage Therapy, some of the therapists have a lack of quality understanding and scientific massage skills, this is a problem in itself at Aqilla's Massage Therapy. This community service activity aims to improve the quality of therapists by providing methods and techniques of massage skills, both theory and practice, so that Aqilla's Massage Therapy therapists can implement them in the field. The method used in the implementation of this service is the lecture, discussion and practice method. This activity involves partners who provide fitness massage therapy services, namely Aqilla's Massage Therapy, which consists of 9 therapists. The result of this community service is to produce quality therapists who can provide services to the community in Banjarbaru, in 2021 there will be an increase in demand for services at Aqilla's Massage Therapy as much as 69%.
Optimalisasi Peran Serta Masyarakat dalam Pengelolaan Sungai di Kelurahan Sungai Miai Kecamatan Banjarmasin Utara Kota Banjarmasin
Authors: Matnuh Harpani , Ruchliyadi Dian Agus , Nugroho Dedy Ari
Published: May 2022

Kota Banjarmasin yang dikenal juga dengan Kota Seribu Sungai, merupakan daerah dengan kondisi geografis dominasi kawasan sungai atau perairan. Kondisi ini merupakan sebuah peluang, sekaligus tantangan bagi masyarakat dan pemerintah dalam hal pengelolaan sungai. Berdasarkan hasil survey lapangan yang dilakukan terhadap keberadaan Sungai Miai di lingkungan RT 11 dan 12 dapat disimpulkan dalam kondisi yang tidak layak atau tidak dapat berfungsi dengan baik karena telah terjadi penyempitan, sedimentasi, dan terjadi pencemaran air yang disebabkan berdirinya bangunan liar di atas sungai, limbah rumah tangga dan jamban keluarga. Pengabdian yang dilakukan mengacu pada kegiatan penguatan partisipasi masyarakat dan pengetahuan mengenai peraturan daerah (Perda) tersebut, sehingga menggunakan pendekatan dialogis, partisipatif, dengan wujud kegiatan sosialisasi kepada masyarakat. Metode yang digunakan dalam pengabdian masyarakat ini adalah menggunakan pendekatan dialogis dengan bentuk sosialisasi kepada masyarakat. Pengabdian ini dilaksanakan pada tanggal 7 Agustus 2021, dengan jumlah partisipan 50 orang yang merupakan masyarakat di wilayah Sungai Miai, Banjarmasin. Hasil yang diperoleh adalah dipahaminya Perda No.15 tahun 2016 tentang Pengelolaan Sungai dan masyarakat memiliki pengetahuan mengenai partisipasi di kawasan sungai. Hasil lain yang disajikan adalah karakter kerja sama dan musyawarah yang dilakukan oleh masyarakat dalam pengelolaan sungai di Sungai Miai Banjarmasin.  Banjarmasin, also known as the City of a Thousand Rivers, is an area with geographical conditions dominated by rivers or waters. This condition is an opportunity and a challenge for the community and the government in terms of river management. Based on the results of a field survey conducted on the presence of the Miai River in RT 11 and 12, it can be concluded that it is in an improper condition or cannot function properly because there has been narrowing, sedimentation, and water pollution caused by the establishment of illegal buildings on the river, sewage household and family latrines. The service carried out refers to activities to strengthen community participation and knowledge of the regional regulation. It uses a dialogical, participatory approach in outreach activities to the community. The method used in this community service is to use a dialogical approach to socialization with the community. This service was carried out on August 7, 2021, with 50 participants who were residents of the Miai River area, Banjarmasin. The results obtained are the understanding of local regulation No. 15 of 2016 concerning River Management and the community knows participation in river areas. Another result presented is the community's character of cooperation and deliberation in river management in Sungai Miai Banjarmasin.
Peningkatan Capacity Building Guru Madrasah Ibtidaiyah Ma`Arif Kabupaten Purbalingga Berbasis Active Learning
Authors: Sahnan Ahmad , Siswadi Siswadi , Setiani Riris Eka
Published: May 2022

Kegiatan pengabdian kepada masyarakat berbasis prodi ini bermaksud untuk menambah pengetahuan sekaligus mengembangkan kapasitas guru-guru Madrasah Ibtidaiyah Ma`arif Purbalingga. Pengabdian ini menggunakan pendekatan andragogik melalui program workshop active learning. Adapun sasaran dari program pengabdian ini ialah guru-guru Madrasah Ibtidaiyah Ma`arif Purbalingga dengan jumlah 30 orang peserta yang dilaksanakan hari kamis 12 Agustus 2021. Materi yang disampaikan meliputi pengelolaan kelas, active learning, dan memahami gaya belajar siswa. Adapun hasil yang dicapai dari program ini bahwa implementasi pembelajaran aktif harus didukung dengan pengelolaan kelas yang baik. Pengelolaan kelas ini merupakan salah satu indikator tercapainya pembelajaran aktif. Selain itu guru-guru memperoleh wawasan dan pengetahuan seputar strategi pembelajaran aktif pada gilirannya proses pembelajaran di sekolah akan berlangsung aktif dan menyenangkan. Melalui program workshop ini guru-guru menyadari bahwa sudah sepatutnya kegiatan seperti ini dilakukan secara berkesinambungan agar sumber daya manusia semakin meningkat dan tentunya kapasitas guru-guru madrasah ibtidaiyah semakin baik ke depannya sehingga melahirkan generasi yang memiliki pengetahuan, keterampilan, nilai dan sukses dalam dunia akademik maupun di luar akademik.  This study program-based community service activity aims to increase knowledge and develop the capacity of madrasah Ibtidaiyah maarif Purbalingga teachers. This service uses an andragogic approach through an active learning workshop program. The targets of this service program are teachers of Madrasah Ibtidaiyah Ma'arif Purbalingga with 30 participants, which will be held on Thursday, 12 August 2021. The material presented includes classroom management, active learning, and understanding student learning styles. The results achieved from this program are that the implementation of active learning must be supported by good classroom management. Classroom management is one indicator of the achievement of active learning. In addition, teachers gain insight and knowledge about active learning strategies, which will make the learning process in schools active and fun. Through this workshop program, teachers realize that activities like this should be carried out continuously to increase human resources. Of course, the capacity of Madrasah Ibtidaiyah teachers will be better in the future to give birth to a generation that has the knowledge, skills, values and success in the academic or outside academic world.
Inscripts and Ownership Stamps in A. I. Klibanov’s Book Collection of SPSTL SB RAS
Authors: Yudin A. A. , Kozhevnikov M. G.
Published: May 2022

The article investigates insufficiently researched issues related to A. I. Klibanov’s book collection. The review of the detected autographs, exlibris and ownership stamps provides an opportunity to determine custodial history of books from both state libraries and personal collections, as well as to reveal unique information about relationships and cooperation between medieval scholars in the second half of the 20th century. The dedicatory inscriptions on the books differ in their length and originality; therefore, their significance as a source is directly proportional to how close a sender and a receiver were. Identification and description of bookplates and stamps in the study of the “Klibanovskaya” collection, still unknown from available reference books, will help in the study of other memorial book collections where such provenance marks can be found. The article also details the features of the formation of the foreign part of the A. I. Klibanov’s book collection. The foreign part of the memorial book collection, which is relatively small compared with the entire collection, can be divided into several thematic blocks: books with autographs donated by researchers dealing with similar scientific problems as the owner of the collection; multi-temporal books on historical and religious subjects, acquired by the owner; instances not related to the previous two blocks. The article identifies, systematizes and describes the inscriptions and ownership marks on the books of the collection of A. I. Klibanov.
Analysis of the Demand for Russian Literature in Shanghai Library
Authors: Zhang X. , Yang T.
Published: May 2022

This research focuses on Shanghai Library users’ demand for Russian literature of different literary periods. Method of sampling and questionnaire were applied for the study. Analyzing the online circulation records of Chinese translations of Russian literature in the main collection of Shanghai Library from 2016 to 2019 and providing an overview of reader demographics are two major tasks. As a typical example, the circulation records of 2019 are thoroughly examined. The aim of the study is to identify the level of demand for Russian literature at various times and the factors influencing the changing trend of demand. The results obtained from the research show that despite the large total number of visitors and the frequency of use of the main collection, the demand for Russian literature was relatively low, especially when compared with other foreign authors. Russian literature from the 19th century and Soviet literature are in the highest demand. Readers didn’t show an obvious interest in contemporary Russian authors. The demand for these three types of authors is clearly uneven. Russian-American writers, as a special group, are also popular choice of readers. The largest reader group consists of middle-aged women. Male readers have a more steadfast and clear preference for one particular author than female readers do. The demand for Russian literature in the library is influenced by such factors, as age and gender, the spread of culture through mass media and social networks, and reading promotion practices by libraries. These factors interact with each other.
Research Support as One of the Activity of a Scientific Library
Authors: Lavrik O. L. , Kalyuzhnaya T. A.
Published: May 2022

The purpose of the article is to present theoretical generalizations on library and information research as aspects of the development of information support for research and development: a classification of a complex of relevant works, products and services and a model that allows determining the level of development for each library based on its tasks and human resources. The methodological possibilities of the developed model are shown: it can be used for personnel training and for the organization of a new library at a research institute, research university under certain requirements.
Topkapı’dan Sâdâbâd’a: 15. Yüzyıldan 18. Yüzyıla Osmanlı Sultanının Sarayında ve İnzivasında Mekânsal Dönüşüm
Authors: BİRKAN Fuat Ozan
Published: May 2022

Ortaçağ ve erken modern dönemde hükümdarın bedenine ve yaşadığı mekâna kutsallık atfetmek, İslami devlet geleneğinin biz özelliğidir. Hükümdar ne kadar az görünür olursa, şahsında temsil ettiği devlet de o kadar kutlu ve mistik bir görünüm kazanırdı. Bu pratiği birçok gelenekten beslenerek devam ettiren Osmanlı İmpartorluğu’nda da sultan 15. yüzyıldan itibaren daha az görünür olmuş ve bir inziva hâline geçmiştir. Daha az görünen sultan inşa ettirdiği saray ve bu sarayda uygulamaya koyduğu protokol kurallarıyla erişilmezliğini daha da arttırmıştır. Yaklaşık iki yüz yıl devam eden bu süreç, 18. yüzyılda terk edilmiş; “görünmeden gören” sultan yerini kendisini “teşhir eden” sultana bırakmıştır. Sultanın beden politikasında ve yaşadığı mekândaki bu değişim kişisel tercihler nedeniyle olduğu gibi içeriden ve dışarıdan gelen çeşitli meydan okumaların ortaya çıkması nedeniyle de gerçekleşmiştir. İçeride yeni yükselen sosyal sınıfların baskısı altındaki sultan, kendisini şehirde gösterme ihtiyacı hissetmiştir. Bu iç baskının yanında sultan aynı zamanda Avrupa’da görülen yeniliklerin ve buna bağlı olarak bir imaj kaygısının da etkisi altına girmiştir. Böylelikle, 15. yüzyıldan 18. yüzyıla gelindiğinde artık bir meşruiyet kaygısına sahip olan Osmanlı sultanları daha görünür ve erişilebilir olmak istemişlerdir.
Nestin+ Mesenchymal Precursors Generate Distinct Spleen Stromal Cell Subsets and Have Immunomodulatory Function
Authors: Huang Jing , Li Minrong , Deng Ronghai , Li Weiqiang , Jiang Meihua , Xiang Andy Peng , Zhang Xiaoran
Published: May 2022

Background
Mesenchymal stromal cells (MSCs) are known to be widespread in many tissues and possess a broad spectrum of immunoregulatory properties. They have been used in the treatment of a variety of inflammatory diseases; however, the therapeutic effects are still inconsistent owing to their heterogeneity. Spleen stromal cells have evolved to regulate the immune response at many levels as they are bathed in a complex inflammatory milieu during infection. Therefore, it is unknown whether they have stronger immunomodulatory effects than their counterparts derived from other tissues.
Methods
Here, using a transgenic mouse model expressing GFP driven by the Nestin (Nes) promoter, Nes-GFP + cells from bone marrow and spleen were collected. Artificial lymphoid reconstruction in vivo was performed. Cell phenotype, inhibition of T cell inflammatory cytokines, and in vivo therapeutic effects were assessed.
Results
We observed Nes-GFP + cells colocalized with splenic stromal cells and further demonstrated that these Nes-GFP + cells had the ability to establish ectopic lymphoid-like structures in vivo. Moreover, we showed that the Nes-GFP + cells possessed the characteristics of MSCs. Spleen-derived Nes-GFP + cells exhibited greater immunomodulatory ability in vitro, and more remarkable therapeutic efficacy in inflammatory diseases, especially TNBS-induced acute colitis than bone marrow-derived Nes-GFP + cells.
Conclusions
Overall, our data showed that Nes-GFP + cells contributed to subsets of spleen stromal populations and possessed the biological characteristics of MSCs with a stronger immunoregulatory function and therapeutic potential than bone marrow-derived Nes-GFP + cells.
The value of virtual touch quantification in assessment of liver function reserve in hepatocellular carcinoma patients: a clinical study
Authors: Liu Chunrui , Gong Li , Wen Baojie , Han Hao , Yang Jian , Wu Min , Mao Liang , Qiu Yudong , kong wen-tao , Yao Jing
Published: May 2022

Purpose: Quantitative assessment of liver function reserve (LFR) plays an important role in clinical management of hepatocellular carcinoma (HCC) patients. Reduced LFR is closely related to increased level of liver fibrosis. Virtual Touch Quantification (VTQ) is a non-invasive ultrasonic imaging technique. In this study, we aimed to explore the correlation between VTQ parameters and LFR levels in different stages of liver fibrosis.Methods: From January 2016 to October 2018, 145 hepatocellular carcinoma patients (114 males and 31 females) scheduled for hepatectomy were enrolled in this study. All patients were histopathologically diagnosed and classified into five groups. The VTQ measurement and indocyanine green (ICG) clearance tests were performed following standard presurgical procedures. VTQ parameters and ICG retention values at 15min (ICG-R15) after ICG injection were compared among all staging groups using non-parametric Kruskal-Wallis test. Correlation between VTQ parameters and ICG-R15 was analyzed for all patients and patients within each staging group. We further divide patients into 3 groups by ICG-R15 values: Group 1 (ICG-R15 < 10%), Group 2 (ICG-R15 10%-20%) and Group 3 (ICG-R15 > 20%). The receiver operating characteristic (ROC) in detection of Group 3 patients using VTQ parameters was analyzed.Results: (1) The ICG R15 values are significantly different among the five-liver fibrosis staging groups (F =7.149, P < 0.001). Moderate correlation was observed between VTQ and ICG R15 values (r = 0.575, p < 0.001) among all patients. (2) VTQ value of Group 2 was significantly higher than that of Group 1 (P = 0.013) and VTQ value of Group 3 was significantly higher than in Group 1 and 2 (P < 0.001; p = 0.005). Classifying a patient to have ICG R15 value greater than 20% (Group 3) given his/her VTQ value is above 1.8 m/s has 100% sensitivity and 78.1% specificity. The area under the ROC is 0.946 (95%CI: 0.895, 0.976, p <0.0001).Conclusions: Non-invasive measurement of VTQ using ultrasound elastography techniques is a valuable tool for clinician to quantify liver fibrosis and assess liver functional reserve in HCC patients, in vivo, which, in turn, helps for the better preoperative planning of HCC patients.
SIMBA: SIngle-cell eMBedding Along with features
Authors: Pinello Luca , Chen Huidong , Ryu Jayoung , Vinyard Michael , Lerer Adam
Published: May 2022

Recent advances in single-cell omics technologies enable the individual and joint profiling of cellular measurements. Currently, most single-cell analysis pipelines are cluster-centric and cannot explicitly model the interactions between different feature types. In addition, single-cell methods are generally designed for a particular task as distinct single-cell problems are formulated differently. To address these current shortcomings, we present SIMBA, a graph embedding method that jointly embeds single cells and their defining features, such as genes, chromatin accessible regions, and transcription factor binding sequences into a common latent space. By leveraging the co-embedding of cells and features, SIMBA allows for the study of cellular heterogeneity, clustering-free marker discovery, gene regulation inference, batch effect removal, and omics data integration. SIMBA has been extensively applied to scRNA-seq, scATAC-seq, and dual-omics data. We show that SIMBA provides a single framework that allows diverse single-cell analysis problems to be formulated in a unified way and thus simplifies the development of new analyses and integration of other single-cell modalities. SIMBA is implemented as an efficient, comprehensive, and extensible Python library (https://simba-bio.readthedocs.io) for the analysis of single-cell omics data using graph embedding.
Connection between high pore-fluid pressure and frictional instability at tsunamigenic plate boundary fault of 2011 Tohoku-Oki earthquake
Authors: Hondori Ehsan Jamali , Park Jin-Oh
Published: May 2022

The 2011 Tohoku-Oki earthquake (M 9.0) rupture propagated along a shallow plate boundary thrust fault (i.e. decollement) to the trench, displaced the seafloor, and triggered a devastating tsunami. Physical properties of the underthrust sediments which control the rupture propagation are yet poorly known. We use a 2D seismic dataset to build velocity model for imaging and apply reverse time migration (RTM). We then calculate pore-fluid pressure along the decollement as the top boundary of underthrust sediments, and along the backstop interface as the boundary between undeformed structures in the continental plate and the severely deformed sediments in the accretionary prism. The results show that within horizontal distance of 40-22 km toward the trench, pore-fluid pressure is 82%-60% higher than the hydrostatic pressure for both decollement and backstop interface. It then reduces to hydrostatic level for the backstop interface but remains 60%-40% higher than hydrostatic level for the decollement, causing frictional instability in favor of fault rupture along the decollement. We report for the first time, by our knowledge, detailed seismic images of fluid-rich trapped bucket sediments, quantitative stress states, and fluid drainage conditions at shallow tsunamigenic portion of the Japan Trench, which are consistent with the seafloor and borehole observations.
Climate and water balance influence on agricultural productivity over the Northeast Brazil
Authors: Vale Tásia Moura Cardoso do , Spyrides Maria Helena Constantino , Júnior Jório Bezerra Cabral , Andrade Lara de Melo Barbosa , Bezerra Bergson Guedes , Rodrigues Daniele Tôrres , Mutti Pedro Rodrigues
Published: May 2022

The identification and delimitation of regions based on their agricultural aptitude is essential in order to assure the effective development and adaptation of climate vulnerable regions, such as the Northeast Brazil (NEB). The objective of this study was to analyze the influence of the water balance on subsistence corn, bean and cassava yields during the period from 1990 to 2019. Thus, we characterized the NEB used meteorological variables (precipitation, temperature, relative humidity and radiation) and water balance elements (potential evapotranspiration, water stored in the soil, water deficit and surplus) in order to determine the best sowing periods for the aforementioned crops. Data was assessed by using different statistical analysis tools such as Mann-Kendall’s test for trend identification, analysis of variance and correlation heatmaps. Results showed an increasing trend for radiation, temperature and potential evapotranspiration in the wetter regions of the NEB. An increase in water deficit conditions was also identified during September-October-November, and therefore a reduction in water stored in the soil during the following months in all regions of the NEB. In the wetter regions, potential evapotranspiration and temperature were positively correlated with bean and corn yields. In the drier regions, on the other hand, water stored in the soil and water surplus were more positively associated with crop yields. For the other climatic types, the following best sowing windows were identified based on the water balance: January through April (semiarid), March through June (dry subhumid), April through July (moist subhumid), March through July (humid B1) and January through June (humid B2).
Features of a FAIR vocabulary
Authors: Xu Fuqi , Juty Nick , Goble Carole , Jupp Simon , Parkinson Helen , Courtot Mélanie
Published: May 2022

Background: The FAIR Principles explicitly require the use of FAIR vocabularies, but what precisely constitutes a FAIR vocabulary remains unclear. Being able todefine FAIR vocabularies, identify features of FAIR vocabularies, and provide assessment approaches against the features can guide the development of vocabularies.Results: We differentiate data, data resources and vocabularies used for FAIR, examine the application of the FAIR Principles to vocabularies, align their requirements with the Open Biomedical Ontologies (OBO) Principles, and propose FAIR Vocabulary Features (FVFs). We also design assessment approaches for FAIR vocabularies by mapping the FVFs with existing FAIR assessment indicators. Finally, we demonstrate how FVFs can be used for evaluating and improving vocabularies using exemplar biomedical vocabularies.Conclusions: The FAIR Vocabulary Features and corresponding indicators can be used to assess the FAIR levels of different types of vocabularies, identify use cases for vocabulary engineers, and guide the evolution of vocabularies.
Atomic-scale identification of the active sites of nanocatalysts
Authors: Miao Jianwei (John) , Yang Yao , Zhou Jihan , Zhao Zipeng , Sun Geng , Moniri Saman , Ophus Colin , Yang Yongsoo , Wei Ziyang , Yuan Yakun , Zhu Cheng , Liu Yang , Sun Qiang , Jia Qingying , Heinz Hendrik , Ciston Jim , Ercius Peter , Sautet Philippe , Huang Yu
Published: May 2022

Heterogeneous catalysts play a key role in the chemical and energy industries1. To date, most industrial-scale heterogeneous catalytic reactions have relied on nanocatalysts2,3. However, despite significant progress from theoretical, experimental and computational studies4-18, identifying the active sites of alloy nanocatalysts remains a major challenge. This limitation is mainly due to an incomplete understanding of the three-dimensional (3D) atomic and chemical arrangement of different constituents and structural reconstructions driven by catalytic reactions19-22. Here, we use atomic electron tomography23-25 to determine the 3D local atomic structure, surface morphology and chemical composition of 11 Pt alloy nanocatalysts for the electrochemical oxygen reduction reaction (ORR). We reveal the facet, surface concaveness, structural and chemical order/disorder, coordination number, and bond length with unprecedented 3D detail. The experimental 3D atomic coordinates are used by first-principles trained machine learning to identify the active sites of the nanocatalysts, which are corroborated by electrochemical measurements. A striking feature is the difference of the ORR activity of the surface Pt sites on the nanocatalysts by several orders of magnitude. Furthermore, by analyzing the structure-activity relationship, we formulate an equation named the local environment descriptor to balance the strain and ligand effects and gain quantitative insights into the ORR active sites of the Pt alloy nanocatalysts. The ability to determine the 3D atomic structure and chemical composition of realistic nanoparticles coupled with machine learning could transform our fundamental understanding of the catalytic active sites and provide a guidance for the rational design of optimal nanocatalysts.
HSD based Computationally Efficient FIR Filter with Retiming Architecture for SDR Application
Authors: SRIVAST AJEET KUMAR , Raj Krishna
Published: May 2022

Optimization of power, speed and hardware utilization are the major concerns in design objectives for modern digital signal processing (DSP) applications. In intermediate frequency (IF) processing unit of SDR receivers, a FIR filter is the main processing element. The redundant number system is extensively used to optimize the arithmetic operations in digital systems. This implementation can further be improved through an architectural transformation at circuit level. In this paper, the use of hybrid signed digit (HSD) number based filter coefficients is proposed for a FIR filter design. Based on the proposed HSD coefficient method in filter computation, a reduction of 16.06% in hardware resources is achieved in comparison to existing methods. In addition, a retiming architecture for an optimized FIR filter is proposed and compared with other existing approaches. The average power consumption is reduced by 13.42% and increases speed by 10.13% in comparison to other existing structures.
The mothers' breastfeeding behavior within six weeks postpartum: new scale development and psychometric validation study
Authors: Wu Jing-Ling , Pang Shu-Qin , Jiang Xiu-Min , Lin Yan , Zheng Qing-Xiang
Published: May 2022

Background
The evaluation of mothers' breastfeeding behavior within six weeks postpartum could help health workers to identify maternal breastfeeding shortcomings comprehensively, clarify nursing problems, and provide targeted interventions. However, no prior study was found and the study aimed to develop and validate the reliability and validity of mothers' breastfeeding behavior scale within six weeks postpartum.
Methods
The main two-step approach was used: (1) A qualitative pilot study using the purposive sampling method was adopted to test fitness, simplicity, and clarity of items with 30 mothers; (2) A cross-sectional survey using the convenient sampling method was conducted for item analysis and psychometric validation with 600 mothers.
Results
The final version of the scale consisted of 36 items with seven dimensions, explaining 68.852% of the total variance. The Cronbach's α, split-half, and re-test coefficients were 0.958, 0.843, and 0.753, respectively. The validity of the scale: (1) Content validity: The content validity indexes (CVI) range of items were between 0.882 and 1.000. The scale-level-CVI was 0.990. (2) Structure validity: The fitting index were as follows: \({\chi }^{2}/df\)=2.239, RMR=0.049, RMSEA=0.069, TLI=0.893, CFI=0.903, IFI=0.904, PGFI=0.674, PNFI=0.763. (3) Convergent validity: The composite reliability and Average Variance Extraction (AVE) of 7 dimensions were between 0.876 and 0.920, 0.594 and 0.696. (4) Distinguish validity: The correlation coefficients were less than the square root of the AVE, excepting self-decision behavior, self-coping behavior, and self-control behavior. However, the fitting index of the original three-factor model was better than other new models with significant differences (P<0.001). (5) Calibration validity: The area under the curve was 0.860 or 0.898 when the scale was used to predict exclusive or any breastfeeding at 42 days. The correlation coefficient of maternal breasting feeding evaluation scale, breastfeeding self-efficacy short-form scale, and the scale were 0.569 and 0.674.
Conclusion
The newly developed mothers' breastfeeding behavior scale within six weeks postpartum consists of thirty-six items belonging to seven dimensions with good reliabilities and validities, a reliable and valid instrument to be used in future maternal breastfeeding behavior assessments and interventions.
Comparison of Ultrasound-guided and Palpation-inserted Peripheral Venous Cannula in Patients Before Primary Hip or Knee Arthroplasty: study protocol for a randomized controlled trial
Authors: Hlasny Jakub , Alberty Roman , Venglarcik Michal , Grey Michael Theodor , Hlavac Marian , Grgac Ivan
Published: May 2022

• Background: More than 2 billion peripheral vascular cannulas are introduced globally each year. It is the most frequently performed invasive procedure in medicine worldwide. There is a group of patients with difficult intravenous access (DIVA). In experts’ hands, ultrasound guided vascular access appears to be a significantly better method. Investigators hypothesize that UGVA is superior also in short term patency of cannula and even for blood draw through cannula. Repeated cannula pricks in the operating room setting not only puts a lot of stress on patient and medical staff, they also waste OR time.• Methods: This investigator-initiated prospective randomized monocentric controlled trial is designed to randomly allocate 400 patients undergoing elective primary total joint arthroplasty of hip or knee to one of two groups as follows: Group C (control group) – peripheral venous cannula insertion by palpation or Group USG (intervention) – cannula insertion by ultrasound guided vascular access. Our primary endpoint is to compare number of attempts for ultrasound guided insertion of peripheral venous cannula with common palpation insertion of peripheral venous cannula in overweight/obese patients (BMI ≥ 25). The secondary endpoint is failure rate of peripheral venous cannula to administer intravenous therapy up to 5 days postoperatively. Tertiary endpoints include portion of long PVCs that are able to ensure blood draw up to 5 days postoperatively, time needed to insert PVC in each group, number of needle tip redirections in both groups, reinsertion of PVC needed in both groups for any reason.• Discussion: This study is pragmatic and is looking for clinically relevant data. After completion it will answer the question whether it is clinically relevant to use ultrasound guided vascular access in the context of not only short-term benefit of insertion, but also up to 5 days after insertion. Also, if this method can ensure blood draw through peripheral vein cannula, it can save resources in perioperative period - valuable especially considering the ongoing shortage of medical staff worldwide. If this hypothesis is confirmed, this finding could contribute to more widespread implementation of ultrasound guided peripheral vascular access in perioperative period.Trial registration: Registered on clinicaltrials.gov 13.12.2021 under CT number: NCT05156008
CircMBOAT2 promotes FASN-mediated lipid metabolism reprogramming and progression in intrahepatic cholangiocarcinoma
Authors: Yu Xiaopeng , Tong Huanjun , Chen Jialu , Tang Chenwei , Wang Shuqing , Si Yu , Wang Shouhua , Tang Zhaohui
Published: May 2022

Background
The carcinogenic role of FASN by regulating lipid metabolism reprogramming has been well established in multiple tumors. However, whether mechanisms during intrahepatic cholangiocarcinoma (ICC) progression such as circRNAs regulate FASN expression remains unknown.
Methods
Five paired ICC and adjacent normal tissues were used to screen the lipid metabolism-associated differentially expressed circRNAs by high-throughput RNA sequencing; the biological role of circMBOAT2 was determined by gain or loss of function experiments. Fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP) and RNA pull-down assays were used to analyze the interaction of circMBOAT2 with PTBP1 and PTBP1 with FASN. Coimmunoprecipitation (co-IP) was used to investigate the ubiquitin binding of PTBP1. Non-targeted lipidomics was applied to detect changes in metabolite composition.
Results
CircMBOAT2 (has_circ_0007334 in circBase) was frequently upregulated in ICC tissues and correlated with tumor size. Knockdown circMBOAT2 inhibits proliferation of ICC cells. Mechanistically, circMBOAT2 combines with PTBP1 and protect PTBP1 from ubiquitin/proteasome-dependent degradation, impairing the function of PTBP1 to transfer FASN mRNA from the nucleus to the cytoplasm. Moreover, circMBOAT2 and FASN have the same effect on fatty acid profile, unsaturated fatty acids instead of saturated fatty acids are primarily regulated and associated with malignant behaviors of ICC cells.
Conclusions
Our results identified that circMBOAT2 stabilized PTBP1 and facilitated ICC lipid metabolic reprogramming via the modulation of FASN mRNA cytoplasmic export, suggesting that circMBOAT2 may serve as an available therapeutic target for ICC with active lipid metabolism.
Systematic Literature Review on Indicators Use in Safety Management Practices Among Utility Industries
Authors: ALI MOHAMAD XAZAQUAN MANSOR , Arifin Kadir , Abas Azlan , Ahmad Mohd Akhir , Khairil Muhammad , Cyio Muhammad Basir , Samad Muhammad Ahsan
Published: May 2022

Due to inadequate safety management systems, workers in utility industries are exposed to occupational accidents. Accordingly, it is necessary to characterise and compares the available literature on indicators used in safety management practices in the utility industries. The systematic literature review was based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. This study considered 25 related studies from Web of Science and Scopus databases. Further review of these articles resulted in three main themes of performance indicators, namely driven leading indicators, observant leading indicators, and lagging indicators consisting of 15 sub-themes. Future studies should consider researching a more comprehensive range of utility industries, measuring subjective and objective indicators, integrating risk management into safety management practices, and validating the influence of leading indicators on safety outcomes. Also, researchers recommend including accidents, fatalities, lost time injuries, and near misses in safety outcomes.
High Surface Area Functionalized Nanolaminated Membranes For Energy Efficient Nanofiltration And Desalination In Forward Osmosis
Authors: Wang Wensen , Onofrio Nicolas , Petit Eddy , Karamoko Bonito , Wu Huali , Liu Jiefeng , Li Ji , Qi Kun , Zhang Yang , Gervais Christel , Lajaunie Luc , Salameh Chrystelle , Miele Philippe , Zeng Zhiyuan , Voiry Damien
Published: May 2022

Stacking two-dimensional (2D) nanosheets into laminar membranes to create nanochannels has attracted widespread attention at fundamental and practical levels for separation technology. Constructing space-tunable and long-term stable sub-nanometer channels provide original systems for nanofluidic investigations and accurate molecular sieving. Although proof-of-concept for nanolaminate membranes has recently been demonstrated, uncontrollable swelling and the presence of pinholes prevent the scaling up of these membranes. Here, we report a scalable strategy for the preparation of non-swelling covalently functionalized molybdenum disulfide (MoS2) membranes with tunable interlayer space. The capillary height of nanochannels was precisely tuned from 3.5 to 7.7 Å, controlled by the nature of the functional groups attached on the MoS2 nanosheets, which exhibit minimal swelling in water. We evaluated the relationship between the capillary height, the surface chemistry, the stacking disorder and the sieving behaviors of the membranes in forwards osmosis (FO). We found that water permeation is strictly controlled by the capillary height of the nanochannels and the stacking disorder of the nanosheets. By combining experimental investigations and numerical simulations, we identified that the functionalization with aryl groups induces the formation of an interlayer space of 7.1 Å and interlayer stiffness as low as 5.6 eV Å-2, leading to controlled stacking defects. We report the fabrication of membranes up to 45 cm2, which demonstrate a salt rejection as high as 94.2% for a continuous operating time of 7 days. Our work presents a desalination strategy in FO with a specific energy consumption (SEC) of 4 × 10-3 kWh m-3, which compares favorably with commercial FO membranes. We anticipate that this opens avenues for the development of FO membranes for desalination based on nanolaminated structure.
Natural Language Processing as a Predictor of Mortality in Intensive Care Unit Patients
Authors: Fusaro Mario V. , Becker Christian , Miller Daniel , Finkel Evan , Hassan Ibrahim F. , Scurlock Corey
Published: May 2022

Background: Artificial intelligence, specifically machine learning, has led to a series of medical publications in recent years. Several studies have used physiologic parameters with machine learning algorithms to derive robust clinical prediction tools. The goal of this study was to use natural language processing in conjunction with physiologic parameters to analyze clinical text data and create a clinical prediction tool. Research Question: Can a natural language processing machine learning based clinical prediction tool accurately predict ICU mortality with relatively limited sample size?Study Design and Methods: Three machine learning classifiers including a support vector machine (SVM), XGBoost Tree, and logistic regression were used to determine probability of hospital mortality in patients admitted to the intensive care unit (ICU) using physician notes and patient physiologic parameters. Discrimination for the binary outcome of life or death will be measured using receiver operating characteristic-area under the curve (AUC). Calibration will be assessed using chi-square goodness of fit.Results: 7,555 patients were available for analysis with 5,288 being included in the derivation set and 2,267 in the validation set. Using the SVM algorithm, the AUC for hospital mortality was 0.895 (95% CI, 0.850-0.940). Calibration was also acceptable with chi square of 7.94 and p = 0.54. The XGBoost Tree algorithm resulted in the best discrimination for mortality with an AUC of 0.912 (95% CI, 0.881-0.943), but calibration was poor. Logistic regression resulted in an AUC of 0.868 (95% CI, 0.827-0.909) but calibration was also poor.Conclusions: A support vector machine learning algorithm can use patient chart data, lab values, and physiologic parameters to generate a clinical prediction tool to predict mortality in ICU patients with a relatively limited dataset. For this study, SVM was superior to logistic regression which is used in many traditional ICU risk predictors.
Treated domestic effluents for non-potable reuse: microbial risk assessment and economic viability
Authors: Santos Luciene da Silva , Souza Hugo Henrique de Simone , Amoah Isaac Dennis , Magri Maria Elisa , Ide Carlos Nobuyoshi , Paulo Paula Loureiro
Published: May 2022

Although water quality can be ensured for various pollutant removal processes, concerns regarding microbial pathogens can set very high-quality standards for treated wastewater rendering the practice financially unfeasible. In this study, we applied quantitative microbial risk assessment and net present value methodologies to evaluate the economic viability and safety of wastewater treatment to produce water for reuse. Under the evaluated conditions, even though applying tertiary treatments (such as chlorination, ozonation, or UV radiation) for non-potable reuse purposes presents higher investment costs, it could offer a faster return on investment as a result of the greater income derived from the sale of the treated wastewater, and consequently, reduce the risk of exposure to pathogens. An economic viability analysis revealed payback periods of three to over 15 years for investment in the universalisation of sanitation services in the selected municipalities, wherein the most feasible scenarios were those in which water reuse was carried out at its maximum potential. We evaluated the reuse potential of treated wastewater in terms of reduced concentrations of Escherichia coli and observed that effluents treated by six wastewater treatment plant configurations (involving secondary treatment processes) could be used for restricted crop irrigation, with disability-adjusted life years (DALYs) of 9.20E03 ± 4.59E05 related to the risk of infection to the farmers. The application of additional disinfection procedures indicated that treated wastewater could be reused for unrestricted and restricted urban and agricultural uses, with corresponding DALYs of 1.35E05 ± 6.73E08 for the same group.
Pulmonary pleura metastasis from low-grade appendiceal mucinous neoplasm with appendiceal neuroendocrine tumor: A Case Report
Authors: Gao Jie , Fan Ruirui , Lu Mingzhi
Published: May 2022

According to the recent World Health Organization (WHO) classification, appendiceal mucinous tumours include low-grade mucinous appendiceal neoplasm (LAMN), high-grade mucinous appendiceal neoplasm (HAMN), and mucinous adenocarcinoma. LAMN is almost the rarest appendiceal tumor with an incidence of about 0.7–1.7%. A ruptured appendiceal mucinous neoplasm can lead to progressive accumulation of mucus in the peritoneal cavity, resulting in pseudomyxoma peritoneum (PMP) with the chance of metastasis and recurrence. Appendiceal neuroendocrine tumor (ANET) is the most frequent appendiceal lesion. A collision between LAMN and ANET is an exceedingly rare condition. So far, evaluating the literature, just 10 cases of collision LAMN and ANET have been reported. Here, we report a case of pulmonary pleura metastasis from LAMN with ANET. Our work will help to improve the accuracy of the diagnosis and avoid misdiagnosis.
Effects of combined RNAi targeting human survivin with hypoxia-inducible factor 1α on gastric cancer BGC-823 cells
Authors: Mu Runhong , Li Yupeng , Chang Mingzhu , Zhu Jianyu , Lin Rui , Ye Siping , Guo Xiao
Published: May 2022

Objective
To investigate the effects of combined RNAi targeting human survivin with hypoxia-inducible factor 1α on gastric cancer BGC-823 cells.
Methods
The hypoxia sensitive gastric cell line BGC-823 was identified firstly. Under hypoxia condition, the survivin targeting siRNA or/and HIF-1α targeting siRNA were transfected into BGC-823 cells. The expression of survivin and HIF-1α were assessed by RT-PCR and Western blotting assay respectively. Cell apoptosis were determined by flow cytometry. Cell proliferation was measured by MTT assay. The abilities of invasion and migration were evaluated by transwell assays and wound healing assays respectively.
Results
The HIF-1α expression of BGC-823 cell increased apparently in the 3 cell lines under hypoxia condition. The survivin targeting siRNA transfection decreased the expression of survivin under hypoxia condition, the combined transfection of survivin targeting siRNA and HIF-1α targeting siRNA down-regulated both the expression of survivin and HIF-1α obviously. Compared with the blank control group, the combined siRNA transfection group displayed obvious features with decreased invasion and migration ability under hypoxia, .the apoptosis rate increased and the cell proliferation decreased obviously.
Conclusion
The down-regulation of survivin and HIF-1α in BGC-823 cell lines may induce an anticancer effect by enhancing cell apoptosis, and decreases the proliferation,migration and invasion ability.