bluuebunny/crossref_metadata_2025 huggingface dataset:
Glycemic index and glycemic load of brief sugary sweets: randomized controlled trials of eight Thai desserts
Authors: Namjud Nuttaphat , Senaprom Sayamon , Ondee Thunnicha , Bumrungpert Akkarach , Heath Julia , Pongpirul Krit
Published: October 2024

Background

Thai desserts, celebrated for their exquisite sweetness, are widely enjoyed for personal indulgence and as cherished souvenirs. However, their high sugar content raises concerns regarding health impacts. This study aimed to quantify the glycemic index (GI) and glycemic load (GL) in healthy volunteers following consumption of various Thai desserts, out of 10 renowned desserts from across Thailand, identified by the Tourism Authority of Thailand, characterized by differing sugar levels.

Method

Eight were selected based on the absence of preservatives and microbial or chemical contaminations. Each participant consumed a 50-g serving of available carbohydrate (50avCHO) from these desserts. Ninety-six healthy volunteers, with a mean age of 31.8 ± 5.7 years, a mean body weight of 57.2 ± 7.3 kg, and 63.5% women, were randomized into eight groups, with each group comprising 12 participants. Blood samples were collected pre-and post-consumption to assess GI and GL values following established protocols.

Results

The findings revealed that Phetchaburi’s Custard Cake exhibited the lowest GI and GL values (53.4 and 26.7, respectively), with progressively higher values observed in Saraburi’s Curry Puff (61.8 and 30.9), Nakhon Sawan’s Mochi (68.9 and 34.4), Suphan Buri’s Sponge Cake (75.9 and 38.0), Ayutthaya’s Cotton Candy (81.4 and 40.7), Prachuap Khiri Khan’s Pineapple Cheese Cake Biscuit (87.4 and 43.7), Chon Buri’s Bamboo Sticky Rice (109.3 and 54.7), and Lampang’s Crispy Rice Cracker (149.3 and 74.7), respectively.

Conclusion

The study demonstrates that while Thai desserts exhibit a range of GI values, their GL values are uniformly high. It underscores the importance of disseminating GI and GL information to consumers, enabling them to make informed dietary choices and moderate their intake of these sugary delicacies.
Association between fish consumption and mortality in the E3N French women’s cohort
Authors: Ba Cira , Marques Chloé , Frenoy Pauline , Ren Xuan , Severi Gianluca , Mancini Francesca Romana
Published: October 2024

Western studies have shown a non-linear association between fish consumption and mortality, which might be explained by exposure to chemical contaminants. This study aims to explore the associations between fish consumption or omega-3 polyunsaturated fatty acids (n-3 PUFA) and mortality within the prospective E3N French cohort, and to investigate the role of dietary exposure to contaminants in these associations. In the E3N cohort composed of 72,585 women, we assessed fish consumption and n-3 PUFA intake through a food questionnaire sent in 1993. To estimate the dietary exposure to contaminants, we used the food contamination database of the second French total diet study. Cox proportional hazard models were used to estimate the association between fish, lean fish, fatty fish, and n-3 PUFA intake, with the risk of all-cause or cause-specific mortality. During the follow-up (1993–2014), 6,441 deaths were recorded. A U-shaped association was observed between fish consumption and all-cause mortality (Poverall_association = 0.017). A similar association was observed with lean fish consumption, while the non-linear association between fatty fish consumption or n-3 PUFA intake and all-cause mortality did not reach statistical significance. A non-linear association was observed between fish consumption and lung cancer mortality (Poverall_association = 0.005). A positive and linear association was observed between fatty fish consumption or n-3 PUFA intake and breast cancer mortality (HR [CI95%]: 1.07 [1.01–1.15] and 1.08 [1.01–1.15]). Our results remained unchanged when further adjusting on dietary exposure to contaminants. Our results showed a U-shaped association between fish consumption and all-cause mortality and suggest a notable role of lean fish consumption in this association, but no role of dietary exposure to contaminants. Further studies are needed to better clarify this U-shaped association and the different impacts of fatty and lean fish consumption on health.
Patient-reported gastrointestinal symptoms in gastric cancer after laparoscopic distal gastrectomy
Authors: Xiao Shuomeng , Ding Zhi , Zhao Fazhi , Yang Chao , Zhao Ping , Chen Xiaodong , Zhou Xiang , Zhou Huali , Xu Rui
Published: October 2024

Purpose

This study aimed to compare postoperative gastrointestinal symptoms between patients who underwent laparoscopic distal gastrectomy with Roux-en-Y (R-Y) and Billroth-II with Braun (B-II B) reconstruction.

Methods

This observational study retrospectively analyzed 151 patients (110 in R-Y group and 41 in B-II B group) who underwent laparoscopic distal gastrectomy from January 2020 to December 2021. A comparison was made regarding surgical outcomes, perioperative nutritional and inflammatory markers, postoperative dietary patterns, and gastrointestinal symptoms between the two groups.

Results

The operation time was longer in the R-Y group than the B-II B group (261.00 ± 56.17 min versus 239.88 ± 57.78 min, p = 0.046). However, there were no significant differences in the length of hospital stay, ASA classification, complications, nutritional and inflammatory indexes, or recovery of postoperative diet between the two groups. Additionally, there were no significant differences in the occurrence of postoperative gastrointestinal symptoms in the post-discharge week (PDW) 1 and postoperative month (POM) 1 between the B-II B and R-Y groups.

Conclusions

Abdominal distention emerged as the main gastrointestinal symptom burden in patients with gastric cancer undergoing laparoscopic distal gastrectomy. Both Billroth-II with Braun and R-Y reconstructions exhibited a high and similar incidence of gastrointestinal symptoms in the short term. Therefore, medical staff should pay attention to the management of gastrointestinal symptoms in these patients postoperatively.
Radioresistance and brain metastases: a review of the literature and applied perspective
Authors: Youssef Andrew , Sahgal Arjun , Das Sunit
Published: October 2024

Intracranial metastatic disease is a serious complication of cancer, treated through surgery, radiation, and targeted therapies. The central role of radiation therapy makes understanding the radioresistance of metastases a priori a key interest for prognostication and therapeutic development. Although historically defined clinic-radiographically according to tumour response, developments in new techniques for delivering radiation treatment and understanding of radioprotective mechanisms led to a need to revisit the definition of radioresistance in the modern era. Factors influencing radioresistance include tumour-related factors (hypoxia, cancer stem cells, tumour kinetics, tumour microenvironment, metabolic alterations, tumour heterogeneity DNA damage repair, non-coding RNA, exosomes, methylomes, and autophagy), host-related factors (volume effect & dose-limiting non-cancerous tissue, pathophysiology, and exosomes), technical factors, and probabilistic factors (cell cycle and random gravity of DNA damage). Influences on radioresistance are introduced and discussed in the context of brain metastases.
Efficacy and safety of ephedra-containing oral medications: a systematic review, meta-analysis, and exploratory dose–response analysis for weight reduction
Authors: Cho Hyeongyu , Oh Jeewoo , Chu Hongmin , Jin Hanbit , Leem Jungtae
Published: October 2024

Introduction

Despite the widespread use of ephedra in various forms, including food supplements and herbal prescriptions, comprehensive studies reviewing its efficacy and safety across different countries are lacking.

Methods

We systematically searched 5 electronic databases and conducted a meta-analysis of 16 randomized controlled trials (RCTs) on ephedra-containing oral medications (EOMs), performing a dose–response analysis for weight loss.

Results

The meta-analysis results revealed a statistically significant reduction in the body mass index (BMI) (MD: 1.5 kg/m2; 95% CI: −2.46 to −0.54) and secondary outcomes like body weight (BW) and waist circumference (WC). The dose–response analysis indicated a correlation between ephedra and weight reduction. The safety analysis showed no significant difference in adverse effects between the treatment and control groups (RR = 0.99, 95% CI = 0.80 ∼ 1.21, and p = 0.90).

Discussion

In conclusion, EOMs demonstrated effectiveness in promoting weight loss, and the dose–response analysis indicated a correlation between ephedra and weight reduction. However, additional research is necessary due to the limited number of studies and inconsistent results among the assessment criteria. Moreover, if prescribed by traditional medicine physicians within the permissible daily ephedrine dosage range of 150 mg set by the Food and Drug Administration (FDA) and monitored by healthcare professionals, the risk of severe adverse events is likely to be minimal.

Systematic Review Registration:

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=387895, identifier CRD42023387895.
Bibliometric and visual analysis of SGLT2 inhibitors in cardiovascular diseases
Authors: Pan Runfang , He Yuqing , Melisandre Wan , Zhang Yunyi , Su Wenyuan , Feng Jiaming , Jia Chengyao , Li Shaoling , Liu Baonian
Published: October 2024

Background

Cardiovascular diseases (CVD) pose a significant threat to human health due to their high mortality and morbidity rates. Despite advances in treatments, the prevalence and impact of cardiovascular disease continue to increase. Sodium-glucose transporter 2 inhibitors (SGLT2i), initially approved for the treatment of type 2 diabetes, have important research value and promising applications in reducing CVD risk, especially in heart failure (HF) and atherosclerosis patients with cardiovascular disease (ASCVD). This study aims to comprehensively review the latest progress, research trends, cutting-edge hot spots, and future development directions of SGLT2i in the field of CVD through bibliometric analysis.

Methods

Articles related to MSCs in cardiovascular diseases were sourced from the Web of Science. The bibliometric analysis was conducted using CiteSpace and VOSviewer, and a knowledge map was created based on the data obtained from the retrieved articles.

Results

In this article, we screened 3,476 relevant studies, including 2,293 articles and 1,183 reviews. The analysis found that the number of papers related to the application of SGLT2i in CVD has generally increased, peaking in 2022. The United States and China contributed the largest number of papers, with the United States accounting for 36.97% of the total and also ranking first in terms of the number of citations. However, China’s high-quality papers are slightly lacking and need further improvement. Keyword analysis showed that empagliflozin, dapagliflozin, diabetes, and heart failure were the most common terms, reflecting the main research interests in currently published papers in this field.

Conclusion

Bibliometric analysis showed a robust and growing interest in the application of SGLT2i for treating CVD. By summarizing the latest progress of SGLT2i in the field of CVD, exploring research hotspots, and looking forward to future research development trends, this article provides valuable insights for thinking about research prospects.
Antidiabetic potential of Lavandula stoechas aqueous extract: insights into pancreatic lipase inhibition, antioxidant activity, antiglycation at multiple stages and anti-inflammatory effects
Authors: Elrherabi Amal , Abdnim Rhizlan , Loukili El Hassania , Laftouhi Abdelouahid , Lafdil Fatima Zahra , Bouhrim Mohamed , Mothana Ramzi A. , Noman Omar M. , Eto Bruno , Ziyyat Abderrahim , Mekhfi Hassane , Legssyer Abdelkhaleq , Bnouham Mohamed
Published: October 2024

Background

With the increasing global prevalence of type 2 diabetes (T2D) and obesity, there is a pressing need for novel therapeutic interventions. Lavandula stoechas, a medicinal plant traditionally used for various ailments, holds promise as a potential agent for T2D management, particularly in Morocco, where it is commonly used to treat diabetes. This study aims to evaluate the pharmacological potential of L. stoechas aqueous extract (AqLs) by assessing its lipase inhibition antioxidant and anti-inflammatory activities, identifying phenolic compounds, and examining its efficacy in reducing diabetic complications.

Methods

The pharmacological potential of L. stoechas aqueous extract was investigated using in vitro assays. The inhibitory effect on pancreatic lipase, antioxidant power (FRAP), and anti-inflammatory activity (albumin denaturation method) was assessed. High-performance liquid chromatography (HPLC) analysis identified phenolic compounds. Additionally, albumin glycation was evaluated by estimating fructosamine, carbonyl groups, and amyloid β-structures to assess efficacy in mitigating diabetic complications.

Results

The extract demonstrated concentration-dependent inhibition of pancreatic lipase (IC50 = 0.132 ± 0.006 mg/mL), potent antioxidant activity (IC50 = 604.99 ± 1.01 μg/mL), and dose-dependent anti-inflammatory effects (IC50 = 207.01 ± 34.94 mg/mL). HPLC analysis revealed phenolic compounds: naringin (38.28%), syringic acid (25.72%), and cinnamic acid (15.88%) were the most abundant, with 4-hydroxybenzoic acid, hydrated catechin, and catechin ranging from 9.60% to 5.24%, and p-coumaric acid (1.73%). Furthermore, the extract inhibited albumin glycation and fructosamine production, suggesting efficacy in mitigating diabetic complications.

Conclusion

These findings highlight the multifaceted pharmacological potential of L. stoechas aqueous extract in T2D management, suggesting that this plant can be highly beneficial for diabetic individuals.
Rehmannia glutinosa DC.-Lilium lancifolium Thunb. in the treatment of depression: a comprehensive review and perspectives
Authors: Wang ZongHao , Wang Xiaoyu , Mou Xiangyu , Wang ChangLin , Sun Ya , Wang JieQiong
Published: October 2024

Background

In recent years, the incidence of depression, recognized as a serious psychological disorder, has escalated rapidly. Rehmannia glutinosa DC. (Scrophulariaceae; Rehmanniae Radix, Crude drug) and Lilium lancifolium Thunb. (Liliaceae; Lilii bulbus, Crude drug) constitute a classic anti-depressant combination, exhibiting pharmacological effects that include anti-depressive, anti-anxiety, and anti-inflammatory properties. Current clinical studies have demonstrated that Baihe Dihuang Decoction, a traditional Chinese herbal compound, is effective in treating depression. However, the majority of scholars have predominantly examined Rehmannia glutinosa and Lilium in isolation, and a comprehensive elucidation of their principal active metabolites and pharmacological mechanisms remains lacking.

Methods

A comprehensive literature search was conducted as of 29 September 2024, utilizing databases such as PubMed, CNKI, Wanfang Data, Baidu Scholar, and Google Scholar. Additionally, classical texts on Chinese herbal medicine, the Chinese Pharmacopoeia, as well as doctoral and master’s theses, were included in the collected materials. The search employed specific terms including “R. glutinosa,” “Lilium,” “Baihe Dihuang decoction,” “application of Baihe Dihuang decoction,” “pathogenesis of depression,” and “pharmacological action and mechanism of depression.

Results

This paper reviewed the traditional applications and dosages of the R. glutinosa-Lilium as documented in Chinese medical classics, thereby establishing a foundation for the contemporary development and clinical application of the classical formula Baihe Dihuang Decoction. Additionally, recent years have seen a comprehensive review of the pharmacological effects and mechanisms of R. glutinosa-Lilium and its principal metabolites in the context of depression.

Conclusion

This paper has reviewed the active metabolites of R. glutinosa-Lilium and demonstrated its efficacy in the treatment of depression, as well as its role in modulating the underlying mechanisms of the disorder. The findings aim to serve as a reference for further research into the mechanisms of depression, its clinical applications, and the development of novel therapeutic agents.
Structure–function relationship of dynorphin B variants using naturally occurring amino acid substitutions
Authors: Zangrandi Luca , Fogli Barbara , Mutti Anna , Staritzbichler René , Most Victoria , Hildebrand Peter W. , Heilbronn Regine , Schwarzer Christoph
Published: October 2024

Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects. Dyn also bind to mu (MOPrs) and delta opioid receptors (DOPrs) with lower affinity and can activate the β-arrestin pathway. To fully exploit the therapeutic potential of dynorphins and reduce potential unwanted effects, increased selectivity for KOPrs combined with reduced activation of the mTOR complex would be favorable. Therefore, we investigated a series of dynorphin B (DynB) variants, substituted in one or two positions with naturally occurring amino acids for differential opioid receptor activation, applying competitive radio binding assays, GTPγS assays, PRESTO-Tango, and Western blotting on single-opioid receptor-expressing cells. Seven DynB derivatives displayed at least 10-fold increased selectivity for KOPrs over either MOPrs or DOPrs. The highest selectivity for KOPrs over MOPrs was obtained with DynB_G3M/Q8H, and the highest selectivity for KOPrs over DOPrs was obtained with DynB_L5S. Increased selectivity for KOPr over MOPr and DOPr was based on a loss of affinity or potency at MOPr and DOPr rather than a higher affinity or potency at KOPr. This suggests that the investigated amino acid exchanges in positions 3, 5, and 8 are of higher importance for binding and activation of MOPr or DOPr than of KOPr. In tests for signal transduction using the GTPγS assay, none of the DynB derivatives displayed increased potency. The three tested variants with substitutions of glycine to methionine in position 3 displayed reduced efficacy and are, therefore, considered partial agonists. The two most promising activating candidates were further investigated for functional selectivity between the G-protein and the β-arrestin pathway, as well as for activation of mTOR. No difference was detected in the respective read-outs, compared to wild-type DynB. Our data indicate that the assessment of affinity to KOPr alone is not sufficient to predict either potency or efficacy of peptidergic agonists on KOPr. Further assessment of downstream pathways is required to allow more reliable predictions of in vivo effects.
Targeting ferroptosis: a novel therapeutic strategy for the treatment of retinal diseases
Authors: Hao Xiao-Dan , Xu Wen-Hua , Zhang Xiaoping , Xue Junqiang
Published: October 2024

Ferroptosis plays a vital role in the progression of various retinal diseases. The analysis of the mechanism of retinal cell ferroptosis has brought new targeted strategies for treating retinal vascular diseases, retinal degeneration and retinal nerve diseases, and is also a major scientific issue in the field of ferroptosis. In this review, we summarized results from currently available in vivo and in vitro studies of multiple eye disease models, clarified the pathological role and molecular mechanism of ferroptosis in retinal diseases, summed up the existing pharmacological agents targeting ferroptosis in retinal diseases as well as highlighting where future research efforts should be directed for the application of ferroptosis targeting agents. This review indicates that ferroptosis of retinal cells is involved in the progression of age-related/inherited macular degeneration, blue light-induced retinal degeneration, glaucoma, diabetic retinopathy, and retinal damage caused by retinal ischemia-reperfusion via multiple molecular mechanisms. Nearly 20 agents or extracts, including iron chelators and transporters, antioxidants, pharmacodynamic elements from traditional Chinese medicine, ferroptosis-related protein inhibitors, and neuroprotective agents, have a remissioning effect on retinal disease in animal models via ferroptosis inhibition. However, just a limited number of agents have received approval or are undergoing clinical trials for conditions such as iron overload-related diseases. The application of most ferroptosis-targeting agents in retinal diseases is still in the preclinical stage, and there are no clinical trials yet. Future research should focus on the development of more potent ferroptosis inhibitors, improved drug properties, and ideally clinical testing related to retinal diseases.
The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategies
Authors: Wang Haitao , Tang Rui , Jiang Ling , Jia Yingtian
Published: October 2024

PIK3CA gene encodes the p110α catalytic subunit of PI3K, which regulates the PI3K/AKT/mTOR signaling pathway. PIK3CA gene mutation is one of the most common mutations in colorectal cancer (CRC), affecting about 15%–20% of CRC patients. PIK3CA gene mutation leads to the persistent activation of the PI3K/AKT/mTOR signaling pathway, which promotes the proliferation, invasion, metastasis, and drug resistance of CRC. This article provides a summary of the key detection methods for PIK3CA gene mutation, and provides an introduction to the existing colorectal cancer treatments and their practical applications in the clinic. Besides, this article summarizes the role and mechanism of PIK3CA gene mutation in the occurrence and development of CRC. It also explores the relationship between PIK3CA gene mutation and the clinical features and prognosis of CRC. This article focuses on the influence and mechanism of PIK3CA gene mutation on the targeted therapy and immunotherapy of CRC, and discusses the potential value and future direction of PIK3CA gene mutation in the personalized therapy of CRC. We aim to provide new perspectives and ideas for the precise diagnosis and treatment of CRC.
Desensitization design of freeform off-axis TMA optical systems with configuration selection
Authors: Ren Chengming , Meng Qingyu , Chen Qi
Published: October 2024

The off-axis three-mirror anastigmatic (TMA) optical system has the advantages of eliminating all primary aberrations, having no aperture obscuration, no chromatic aberration, and good environmental adaptability, making it essential in high-performance optical instruments. Freeform surfaces, with their rich degrees of freedom (DOFs) in mathematical representation, positively affect the image quality and sensitivity of optical systems. When applied correctly to off-axis TMA optical systems, they can achieve fast F-numbers, large fields of view (FOVs), and long focal lengths. There are dozens of configurations for off-axis TMA optical systems, and freeform surfaces can be combined in numerous ways within these systems. This paper first analyzes the sensitivity of off-axis TMA optical systems with different configurations, selects the configuration with the lowest sensitivity, and combines it with a low sensitivity freeform surface combination to achieve high-performance freeform off-axis TMA optical systems with low sensitivity.
Analysis of the mechanical properties and micro-reinforcement mechanisms of loose accumulated sandy soil improved with polyvinyl alcohol and sisal fiber
Authors: Sang Ding , Wang Peiqing , Chen Liang , Zhang Wengang , Liu Zhen , Wang Qi
Published: October 2024

As one of the world’s most fragile and sensitive ecological regions, Xizang risks significant environmental damage from using traditional materials, including cement and lime, to improve and reinforce loose accumulated sandy soil slopes. To address this issue, this study utilized a low-concentration biodegradable polyvinyl alcohol (PVA) solution combined with sisal fibers (SFs) to stabilize loose accumulated sand in southeastern Xizang. A series of physical, mechanical, and microscopic analyses was conducted to evaluate the properties of the treated sand. The results indicated the following. 1) The stress-strain curves of the improved samples exhibited an elastic-plastic relationship. Failure was observed in two stages. At a strain of 3% or less, the samples demonstrated elastic deformation with a linear increase in stress, whereas the deviator stress increased rapidly and linearly with an increase in axial strain. Once the strain exceeded 3%, the deformation became plastic with a nonlinear increase in the stress-strain relationship, and the growth rate of the deviator stress gradually decreased and leveled off. 2) Under varying confining pressure conditions, the relationship curve between the maximum (σ1-σ3)max∼σ3 for both untreated loose accumulated sandy soil and soil improved with the PVA solution, and the sisal fiber was approximately linear. 3) The SFs created a skeletal-like network that encased the soil particles, and the hydroxyl functional groups in the PVA molecules bonded with both the soil particles and the fiber surface, thereby enhancing the interfacial properties. This interaction resulted in a tighter connection between the soil particles and SFs, which improved the stability of the structure. 4) The incorporation of a PVA solution and SFs significantly enhanced the mechanical strength and deformation resistance of the loose accumulated sandy soil. The optimal ratio for the improved soil was SP = 3% and SL = 15 mm, which increased the cohesion from 24.54 kPa in untreated loose accumulated sandy soil to 196.03 kPa. These findings could be applied in engineering practices to improve and reinforce loose accumulated sandy soil slopes in southeastern Xizang and provide a theoretical basis for such applications.
Psychological barriers in children: an exploratory study on Dengue transmission using an adapted DIPB scale
Authors: Schimmelpfeng Pedro , Lapa Luiz Gonzaga , Lyra Pato Claudia Marcia
Published: October 2024

Dengue is an arboviral infection found in tropical and subtropical regions transmitted by hematophagous mosquitoes from the genus Aedes spp. and responsible for millions of cases every year. Public campaigns and educational curriculum are designed to educate people, including children. However, what has been reported is that many decide not to follow these guidelines, even though they allegedly know what has to be done. To understand this phenomenon, this study aims to identify psychological barriers behind the adoption of pro-environmental behaviors that seek to reduce Aedes aegypti’s population. For that, middle school students participated on two studies responsible for (1) adapting the Dragons of Inaction Psychological Barrier (DIPB) scale to the target group (n = 150) and then (2) testing it on a larger group (n = 449). In the exploratory factor analysis, Bartlett correlation (p < 0.001), Cronbach’s alpha (0.83), and KMO analysis (overall MSA = 0.84) showed that data was suited for factor analysis. Five factors were retained by Kaiser Criterion and scree test (i.e., Conflicting goals and unnecessary changes—α 0.76, Interpersonal relations—α 0.72, Conflicting goals and lacking knowledge—α 0.58, Tokenism—α 0.73, and Tokenism toward the government—α 0.66). After that, the scale was tested across 11 different schools, where students also answered a questionnaire about the mosquito. Results suggested that the factors Conflicting goals and lacking knowledge and Tokenism toward the government presented a higher level of agreement for all students (means: 2.6 and 2.12 out of five, respectively). Those who scored higher in the mosquito’s questionnaire had factors Conflicting goals and unnecessary change and Interpersonal relations inhibited when compared to others (p < 0.05). These results suggests that future educational campaigns should build different actions that focuses on addressing both internal and external factors, creating a mosaic of projects, with different goals, each aiming different environmental challenges.
Depression and associated factors among patients with type 2 diabetic mellitus in Ethiopia: a cross sectional study
Authors: Dukato Amanuel , Beyamo Abera , Habte Hailegebireal Aklilu , Teklehaimanot Wegayehu Zeneb , Ayfokru Abatwoy , Alemnew Metages , Birhanu Abate Daniel , Abemie Worku , Mengistu Bethlehem Taye , Ayehu Dessie Yihenew , Mengstie Leweyehu Alemaw , Girma Bekahegn
Published: October 2024

Background

Depression is a significant public health concern in both developed and developing countries. The burden of depression is particularly high among patients with chronic illnesses in developing countries, creating a dual challenge for both patients and the community. However, depression goes undiagnosed in 50%-75% of patients with chronic conditions such as diabetes mellitus. Additionally, there is limited information about the prevalence of depression among diabetic patients in Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of depression among type 2 diabetic patients in Ethiopia.

Method

An institution-based cross-sectional study was conducted on 376 randomly selected type 2 diabetic patients. Data were collected through face-to-face interviews and from patients’ follow-up records. The data were entered into EpiData version 4.6 and analyzed using STATA 14. Bivariable and multivariate logistic regression analyses were employed to identify associated factors. Variables with a p-value of less than 0.25 in the bivariable analysis were selected for multivariate logistic regression. Model fitness was assessed using Hosmer-Lemeshow’s test, and associations were reported using adjusted odds ratios with 95% confidence intervals

Results

In this study, the prevalence of depression among type 2 diabetic patients was found to be 69.72% (95% CI: 64.75, 74.27). Three factors were significantly associated with depression in these patients: the duration of diabetes mellitus since diagnosis [AOR: 1.17; 95% CI (1.02, 1.34)], glycaemic control [AOR: 1.8; 95% CI (1.09, 3.01)] and cigarette smoking [AOR: 2.18; 95% CI (1.07, 4.46)].

Conclusion

The prevalence of depression among type 2 diabetic patients was high. The Federal Ministry of Health, stakeholders, and the Ethiopian Diabetes Association should collaborate to reduce this burden. Mental health assessment and treatment should be integrated into chronic care follow-up services. Additionally, healthcare providers should closely monitor and counsel patients who smoke and those with poor glycemic control.
Incivility, bullying, and poor health and well-being among students: a Swedish national study in higher education institutions
Authors: Mensah Aziz , Toivanen Susanna , Björklund Christina
Published: October 2024

Objective

Exposure to incivility and bullying among students in higher education institutions may have detrimental health and well-being outcomes. Nevertheless, the mechanism and interconnected pathways through which incivility and bullying are linked with poor health and well-being remain largely unexplored. The aim of this study is to investigate the relationships between incivility, bullying, and poor health and well-being among students in higher education institutions in Sweden, and whether gender influences these relationships. Furthermore, we examine whether bullying plays a mediating role in the relationship between incivility and poor health and well-being.

Methods

We analyzed a cross-sectional dataset of students drawn from 38 universities that are members of the association of Swedish higher education institutions. The data were collected from May to July 2021, covering 11,162 women and 6,496 men. Confirmatory factor analysis and structural equation modeling (SEM) were utilized to estimate the relationships between incivility, bullying, and poor health and well-being. Additionally, multigroup analysis was applied to estimate the interactive effect of gender in these relationships.

Results

Reports of both incivility and bullying were more prevalent among women than men. The results showed that incivility had direct relationships with both bullying β=0.578,p<0.01 and poor health and well-being β=0.301,p<0.01. However, the relationship between bullying and poor health and well-being was not significant. There were statistically significant gender differences in the relationships between incivility, bullying, and poor health and well-being (Δχ223=179.18,p<0.01). Nevertheless, bullying did not significantly mediate the relationship between incivility and poor health and well-being.

Conclusion

The current study demonstrates that governments, university authorities, and policymakers must consider gender differences in incivility and bullying when developing policies and interventions intended to reduce these kinds of behaviors in organizations.
Associations between Recession hardships and subjective and objective sleep measures in the midlife in the United States study: race and gender differences
Authors: Bhat Aarti C. , Diaz Jose A. , Lee Sun Ah , Almeida David M. , Lee Soomi
Published: October 2024

Objectives

This study investigates the associations of retrospective reports of Recession hardships with 10-year changes in subjective and objective indicators of sleep, and whether these associations differ by race and gender.

Methods

Five hundred and one adults (14.57% Black; 54.49% female) from the Midlife in the United States (MIDUS) study reported on the subjective Pittsburgh Sleep Quality Index (PSQI) across two waves (pre-Recession, collected 2004–2009; post-Recession, collected 2017–2022), as well as Recession hardships since 2008. A sub-sample of 201 adults (25.37% Black; 58.21% female) provided objective actigraphy-measured sleep data (total sleep time, sleep onset latency, and sleep efficiency) across the two waves.

Results

Descriptive analyses revealed Black participants had higher average Recession hardships, poorer post-Recession PSQI scores, and poorer post-Recession actigraphy sleep quantity and quality compared to white participants. Females had higher average Recession hardships compared to males; and reported poorer post-Recession PSQI, but had better objective post-Recession sleep quantity and quality compared to males. Regression models showed Recession hardships (across overall events, and sub-domains of financial and housing hardships) were associated with poorer PSQI and actigraphy-measured sleep efficiency following the Recession, adjusting for sociodemographic covariates, corresponding pre-Recession sleep variables, and pre-Recession chronic conditions. There was no evidence for significant moderation by race on sleep outcomes. However, gender moderation indicated associations between housing hardships and poorer actigraphy-measured sleep efficiency were more apparent for females than for males.

Conclusions

Findings indicate that Recession hardships (particularly in financial and housing domains) may be manifested in poor sleep. Racial and gender groups may have differential exposure and sleep-related reactivity to Recession hardships.
Groundwater stress in Europe—assessing uncertainties in future groundwater discharge alterations due to water abstractions and climate change
Authors: Söller Linda , Luetkemeier Robert , Müller Schmied Hannes , Döll Petra
Published: October 2024

Groundwater sustains human well-being and ecosystems functioning. Many regions in Europe have experienced declining groundwater levels caused by decreasing groundwater recharge (GWR) or increasing groundwater abstractions (GWAs). These changes can lead to groundwater-related stress, threatening ecosystems and water supplies. Existing groundwater stress indicators estimate stress during a given period but do not address how stress changes or show the uncertainty of future stress. We propose a novel indicator of future groundwater stress (GWSI) due to changes in GWR and GWA and, thus, the alteration of long-term mean annual groundwater discharge (GWD). Groundwater stress is defined as any alteration in GWD since ecosystems are adapted to an equilibrium state. Focusing on decreasing GWD, which is generally more harmful than increasing GWD, we quantified the future GWSI in Europe by integrating scenarios of GWR and GWA in 2070–2099. GWR was evaluated using an ISIMIP2b multi-model ensemble of eight global hydrological models driven by the output of four global climate models under two greenhouse gas emission scenarios. GWA scenarios for irrigation, domestic and manufacturing sectors were combined with the GWR projections to generate an ensemble of GWSIs, simplified into three groundwater stress scenarios (high, intermediate, low). Projected GWSIs vary significantly among the scenarios. For the high-stress scenario, 58% of Europe’s land area is projected to experience a GWD decrease of at least 25% under RCP8.5 compared to 38% under RCP2.6, while the respective values are 26 and 1% for the intermediate-stress scenario. Groundwater demand management alone might not prevent GWD declines under the high-stress and intermediate scenarios, particularly under RCP8.5. Therefore, climate change mitigation might imperative for reducing the decline of GWD, especially in Eastern and Southeastern Europe, where changes in GWR are projected to be the primary cause of declining GWD (in the high abstraction scenario under RCP8.5). Under RCP2.6, reductions in GWAs by 25–75% might balance a GWD decline in parts of Spain and Italy where GWAs are high, even in the high-stress scenario. In line with the precautionary principle, we recommend adapting to the high-stress scenario to minimize harm to the beneficiaries of groundwater.
Acoustics in Baroque Catholic Church Spaces
Authors: Alberdi Enedina , Galindo Miguel , León-Rodríguez Angel L. , León Jesús
Published: October 2024

After the Council of Trent (1545–1563), the Catholic Church undertook a profound renovation, which affected the spatial configuration of the churches to adjust to the spirit of the Counter-Reformation. The acoustic cultural heritage in these spaces have been studied by different researchers, proposing the joint analysis of 66 Catholic churches from the Baroque period. This study delves into the global characterisation of the sample and establishes correlations between geometric and acoustic parameters. From the acoustic analysis, it is clear that the central floor typology, as opposed to Latin cross churches, presents better average values of musical clarity in relation to their volume. The analysis of the relationship between acoustic and geometric parameters, when the sample of churches is discriminated by typology, allows for the establishment of appropriate correlations for Latin cross floor plans, single naves and basilicas, but not when the analysis is carried out for the entire sample. These correlations are a tool that allows us to evaluate acoustic parameters not measured in situ in Catholic churches of the Baroque period in a predictive way as a function of other measured acoustic or geometric parameters.
Design of Positive Pressure Re-Acceleration Assisted Seeding Mechanism for Corn Based on CFD-EDEM Gas-Solid Coupling Simulation
Authors: Li Liwei , Wu Guangwei , Meng Zhijun , Xiao Yuejin , Yin Yanxin , Yan Bingxin , Zhao Chunjiang
Published: October 2024

This study proposes a positive pressure re-acceleration assisted seeding mechanism and analyzes the motion mechanism of corn seeds during the seeding process. By employing the CFD-EDEM gas-solid coupling simulation analysis method, the fluid characteristics, initial ejection velocity of seeds, seed dropping time difference, and sowing position difference in the seeding mechanism under different structural parameters of the air pressure valve body were investigated. The optimal structural parameters of the air pressure valve body were determined (nozzle gap c = 0.6 mm, throat constriction diameter d = 16 mm, and throat constriction length l = 44 mm). A multi-factor experimental method was used to explore the effects of airflow pressure, forward speed during sowing, and sowing distance on sowing performance, aiming to identify the optimal working parameters for the positive pressure re-acceleration seeding mechanism. High-speed camera technology was used to record and analyze the seed movement process. The results indicate that an increase in positive pressure within the seed guide tube shortens the sowing time of corn seeds, reduces the coefficient of variation of seed dropping time difference, and effectively improves the consistency of sowing distance. The optimal parameters are a forward speed of 8 km/h, sowing distance of 20 cm, airflow pressure of 10 kPa, with a sowing distance coefficient of variation of 7.56%, and a seed dropping time difference coefficient of variation of 5.35%.
TRust Your GENerator (TRYGEN): Enhancing Out-of-Model Scope Detection
Authors: Diviš Václav , Spatz Bastian , Hrúz Marek
Published: October 2024

Recent research has drawn attention to the ambiguity surrounding the definition and learnability of Out-of-Distribution recognition. Although the original problem remains unsolved, the term “Out-of-Model Scope” detection offers a clearer perspective. The ability to detect Out-of-Model Scope inputs is particularly beneficial in safety-critical applications such as autonomous driving or medicine. By detecting Out-of-Model Scope situations, the system’s robustness is enhanced and it is prevented from operating in unknown and unsafe scenarios. In this paper, we propose a novel approach for Out-of-Model Scope detection that integrates three sources of information: (1) the original input, (2) its latent feature representation extracted by an encoder, and (3) a synthesized version of the input generated from its latent representation. We demonstrate the effectiveness of combining original and synthetically generated inputs to defend against adversarial attacks in the computer vision domain. Our method, TRust Your GENerator (TRYGEN), achieves results comparable to those of other state-of-the-art methods and allows any encoder to be integrated into our pipeline in a plug-and-train fashion. Through our experiments, we evaluate which combinations of the encoder’s features are most effective for discovering Out-of-Model Scope samples and highlight the importance of a compact feature space for training the generator.
Management Effects on Gastrointestinal Disease in Red Wolves (Canis rufus) Under Human Care: A Retrospective Study
Authors: Fontaine Amy Clare , Campbell Jennifer , Opperman Logan , Minter Larry J. , Wolf Karen , Anderson Kadie M. , Kendall Corinne J. , Lynch Emily C.
Published: October 2024

Red wolves (Canis rufus) are the most critically endangered wolf globally, with over 95% of individuals living under human care. Gastrointestinal (GI) disease is one of the leading causes of death among adult red wolves under human care, yet links between management practices and this condition remain unclear. By integrating studbook data, survey-based husbandry information, veterinary records, and necropsy reports, our study explored the relationships between management practices and post-mortem diagnoses of GI mucosal disease among 36 adult red wolves between 2004 and 2022. For final diets fed for a minimum of 4 months before death, we report that wolves fed diets limited to only kibble were more likely to exhibit a greater severity of GI mucosal disease than those fed diets that integrated whole prey or other meat items. In addition, while living at their final facilities for a minimum of 9 months before death, wolves treated with a nonsteroidal anti-inflammatory drug exhibited more severe GI issues than those who were not. Conversely, we found no effect of housing and life history traits on GI health. This study highlights the importance of evaluating management and veterinary protocols on red wolf GI health.
Computational Prediction and Structural Analysis of α-Hairpinins, a Ubiquitous Family of Antimicrobial Peptides, Using the Cysmotif Searcher Pipeline
Authors: Slavokhotova Anna A. , Shelenkov Andrey A. , Rogozhin Eugene A.
Published: October 2024

Background: α-Hairpinins are a family of antimicrobial peptides, promising antimicrobial agents, which includes only 12 currently revealed members with proven activity, although their real number is supposed to be much higher. α-Hairpinins are short peptides containing four cysteine residues arranged in a specific Cys-motif. These antimicrobial peptides (AMPs) have a characteristic helix−loop−helix structure with two disulfide bonds. Isolation of α-hairpinins by biochemical methods is cost- and labor-consuming, thus requiring reliable preliminary in silico prediction. Methods: In this study, we developed a special algorithm for the prediction of putative α-hairpinins on the basis of characteristic motifs with four (4C) and six (6C) cysteines deduced from translated plant transcriptome sequences. We integrated this algorithm into the Cysmotif searcher pipeline and then analyzed all transcriptomes available from the One Thousand Plant Transcriptomes project. Results: We predicted more than 2000 putative α-hairpinins belonging to various plant sources including algae, mosses, ferns, and true flowering plants. These data make α-hairpinins one of the ubiquitous antimicrobial peptides, being widespread among various plants. The largest numbers of α-hairpinins were revealed in the Papaveraceae family and in Papaver somniferum in particular. Conclusions: By analyzing the primary structure of α-hairpinins, we concluded that more predicted peptides with the 6C motif are likely to have potent antimicrobial activity in comparison to the ones possessing 4C motifs. In addition, we found 30 α-hairpinin precursors containing from two to eight Cys-rich modules. A striking similarity between some α-hairpinin modules belonging to diverse plants was revealed. These data allowed us to assume that the evolution of α-hairpinin precursors possibly involved changing the number of Cys-rich modules, leading to some missing middle and C-terminal modules, in particular.
Management of Fracture-Related Infection in Conflict Zones: Lessons Learned from Medical Missions to Gaza
Authors: Nasser Elias , Alshaer Nour , Wajahath Muaaz , Irfan Bilal , Tahir Mohammed , Nasser Mosab , Saleh Khaled J.
Published: October 2024

Background/Objectives: Fracture-related infections (FRIs) are a significant complication in conflict zones, where limited resources and damaged infrastructure complicate orthopedic care. Methods: This study retrospectively reviews the management of FRIs during medical missions to Gaza from April to July 2024. Results: Among 135 patients treated for war-related fractures, 30% were identified with suspected FRIs, which were primarily following explosive injuries. Contributing factors to the high incidence of infection included malnutrition, poor sanitation, and the scarcity of sterile surgical supplies. The absence of standard infection control measures further complicated treatment. Conclusions: These findings highlight the critical need for a comprehensive approach that incorporates infection prevention, sustainable healthcare planning, and quality assurance tailored to the realities of conflict zones. The study underscores the importance of international support to ensure the availability of essential medical supplies and to develop effective, context-specific strategies for infection management. By applying these insights, healthcare providers can improve patient outcomes and reduce the burden of FRIs in resource-limited settings affected by conflict.