bluuebunny/crossref_metadata_2025 huggingface dataset:
KEBIJAKAN PENGHAPUSAN SANKSI PIDANA TERHADAP TINDAK PIDANA LINGKUNGAN HIDUP DALAM UNDANG-UNDANG NOMOR 11 TAHUN 2020 TENTANG CIPTA KERJA
Authors: LUBIS ALFIKRI LUBIS
Published: February 2022

AbstractThe formation of the Employment Creation law is directed at harmonization with regard to several legislative materials which are considered overlapping. One of the interesting topics to examine in Law Number 11 of 2020 concerning Employment Creation is the elimination of criminal sanctions against criminal acts of the Environment replaced with administrative sanctions. This provision is seen in Article 23 point 37 which changes Article 102 in Law Number 32 Year 2009 concerning Environmental Protection and Management. The amendment to Article 82 B in the Employment Creation Law only takes the form of administrative sanctions and does not include the types of criminal sanctions that can be imposed. The elimination of criminal sanctions against environmental crimes which are replaced by administrative sanctions signals the weakening of law enforcement against the environment. Meanwhile, environmental problems are getting bigger, wider and more serious. The problem is not only local or translocal, but regional, national, transnational and global in nature. Criminal sanctions are still considered to be the most effective and ultimate sanctions in tackling a crime, especially since the crime rate gives a very large loss.Keywords: Abolition of criminal sanctions, environmental crimes, administrative sanctionsAbstrakPembentukan undang-undang Cipta Kerja diarahkan pada harmonisasi terkait dengan beberapa materi peraturan perundang-undangan yang dianggap saling tumpang tindih. Salah satu topik yang menarik untuk ditelaah dalam Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja tersebut adalah penghapusan sanksi pidana terhadap tindak pidana Lingkungan Hidup diganti dengan sanksi administrasi. Ketetuan tersebut dalam dilihat dalam Pasal 23 angka 37 yang merubah Pasal 102 didalam Undang-Undang Nomor 32 Tahun 2009 tentang Perlindungan dan Pengelolaan Lingkungan Hidup. Perubahan Pasal 82 B dalam Undang-Undang Cipta Kerja hanya berupa sanksi administrasi dan tidak mencantumkan jenis sanksi pidana yang dapat dijatuhkan. Penghapusan sanksi pidana terhadap tindak pidana Lingkungan Hidup yang diganti dengan sanksi administrasi memberikan sinyal semakin melemahnya penegakan hukum terhadap lingkungan hidup. Sementara masalah lingkungan hidup semakin lama semakin besar, meluas, dan serius. Persoalannya bukan hanya bersifat lokal atau translokal saja, tetapi sudah bersifat regional, nasional, transnasional, dan global. Sanksi pidana masih dianggap sebagai sanksi yang paling ampuh dan pamungkas dalam menanggulangi suatu kejahatan apalagi tingkat kejahatan tersebut memberikan kerugian yang sangat besar.Kata Kunci: Penghapusan sanksi pidana, tindak pidana lingkungan Hidup, sanksi administrasi
ADVANCE IN THE METHOD OF MANUFACTURE AND USE OF EXPRESS DIABETIC HONEY FOR HEALTH IMPROVEMENT
Authors: Bosenko Anatolii , Plahtiy Petro , Topchii Mariia , Kozak Yevhen , Bosenko Olena
Published: February 2022

The article is devoted to the problem of making express diabetic honey to prevent and improve health, as well as
to treat diabetic individuals. The disease has become extremely widespread both globally and in individual countries. It
was registered that over 425 million people have diabetes for the current year. According to this situation, the medical
expenses reach up to 727 billion US dollars, which could be spent to the improvement of the quality of living standards.
The number of cases of diabetes is about 1.3 million adults against the backdrop of difficult demographic situation in
Ukraine. Unfortunately, there is a negative trend in our country towards the spread of the disease among young people
and children, even preschoolers. In accordance with a prognostic point of view, the prospect of today's young generation seems highly undesirable – that is, to be among people with this pathology all their lives. Therefore, solving the
problem through prevention and healthy lifestyle is important. Due to shortages of medicines and financial support for
certain population category, the solution in this case is seen in the expansion of folk remedies for prevention and treatment, the leading place among which are bee products. The aim of the study was to develop a method of making diabetic express honey from blueberries (Vaccinium myrtillus L.), Jerusalem artichoke (Helianthus tuberosus L.), common
beans (Phaseolus vulgaris L.) and to study its effect on changes in glucose, total protein and plasma protein fractions
(PPF) of diabetics. According to studies of two groups of males (control and experimental) aged 50-70 years with a
total of 24 people, it was found that the use of developed by the author's methodology of express diabetic honey from
blueberries, Jerusalem artichokes and common beans helps to stabilize blood glucose levels; it has a positive effect on
protein metabolism and immunity of diabetics, as well as enhances the effect of oral antidiabetic drugs.
Amelioration of the Abnormalities Associated with Metabolic Syndrome by L-Norvaline in Hyperlipidemic Diabetic Rats
Authors: Dobhal S. , Baliyan S. , Singh MF. , Bisht S. , Setya S.
Published: February 2022

The present study was designed to assess the treatment effect of arginase inhibitor, L-Norvaline in abnormalities associated with high fat diet (HFD) and fructose-induced metabolic syndrome. The HFD and fructose was fed to the rats for a period of 45 days. Animals having body weight of 350 g and fasting blood sugar level of more than 250 mg/dl were considered as hyperlipidemic diabetic rats (HDR) and selected for the study. The HDR were divided into three groups having six animals each. The HDR received L–Norvaline (10 mg/kg/day, i.p.) and standard drug, gemfibrozil (60 mg/kg/day, p.o.), for a period of 30 days. Various hormonal, biochemical and tissue parameters were evaluated at the end of the study. Both treatments significantly decreased body weight, BMI, fasting blood sugar and insulin level and improved insulin resistance in HDR as compared to the toxicant control group. A significant improvement was observed in the lipid profile, levels of nitrate, leptin, C-reactive protein and adiponectin in HDR. L-Norvaline also caused slight decrease in the malondialdehyde level, though, no prominent effect was observed on the level of superoxide dismutase and reduced glutathione in the pancreas of HDR, as compared to the toxicant control group. L-Norvaline treatment also improved the histo-architecture of pancreatic cells. Results of the present study concludes that L-Norvaline caused significant alleviation of the abnormalities of MetS indicating that it can be used as potential treatment strategy for managing the symptoms of metabolic syndrome.
Ausgewählte Verlags- und Übersetzerkorrespondenzen
Authors: Jaspers Karl
Published: February 2022

Karl Jaspers war als Autor an einer möglichst breiten Wirkung gelegen, weswegen er auch einen intensiven Kontakt zu seinen Verlagen pflegte. Schon deshalb kommt den einschlägigen Briefwechseln (erhalten sind insgesamt etwa 6.000 Briefe) biographisch und werkgeschichtlich zentrale Bedeutung zu. Denn die bisher unveröffentlichten Korrespondenzen aus der Zeit zwischen 1911 und 1968 geben nicht nur wesentliche Einblicke in die Persönlichkeit und das Leben von Karl Jaspers, sondern ebenso in sein Selbstverständnis als Psychopathologe, Psychologe, Philosoph und politischer Schriftsteller. Vielfach legen sie offen, wie er historische und zeitgenössische Personen, politische Ereignisse oder Konstellationen bewertete, doch bisweilen beleuchten sie umgekehrt auch das Verhalten einiger Verlage ihm gegenüber während der NS-Zeit. Insbesondere aber informieren die Briefe über seine Monographien und Aufsätze, indem sie deren Entstehung und Rezeption zu Tage treten lassen oder von mitunter mühsamen und nicht immer erfolgreichen Übersetzungsverhandlungen berichten. Dokumentiert ist auch der Austausch über wichtige Buchprojekte, die zu Jaspers’ Lebzeiten nicht mehr realisiert wurden (etwa die «Verstehende Psychologie» oder «die Grundsätze des Philosophierens»).
Der vorliegende Band enthält u.　a. Briefwechsel mit den Verlagen Artemis, Francke, de Gruyter, Les Éditions de Minuit, Harper und Row, Meiner, Mohr Siebeck, Routledge, Lambert Schneider, Springer, Storm, Suhrkamp, University of Chicago Press und Yale University Press, mit den Verlegern Kurt und Helen Wolff sowie mit den Übersetzern E.B.　Ashton, Noboru Hosoo, Hélène Naef, Paul A. Schilpp, Ré Soupault und Jean Wahl. Die Briefe werden in Auswahl, aber jeweils vollständig wiedergegeben.
Der zweite Teilband (KJG III/8.2) widmet sich ausschließlich den Korrespondenzen mit Klaus Piper und dem Piper Verlag.
Study of maneuverability and behavior in the sea of the Light Cabotage and Logistics Support Vessel (BALC-L)
Authors: Naranjo Tabares David , Muñoz Ortega José David , Valderrama Matallana Juan Manuel , Riola Rodriguez José María
Published: February 2022

Colombia's hydrographic wealth is of great importance for the development of the economic sectors throughout the country, and together with neighboring countries such as Peru and Brazil, different needs arising from the difficult access to their more remote populations are shared. This is why, humanitarian missions are carried out through the ships of the Colombian Navy (ARC), which are at the service of the most remote civilian populations, providing, for example, response to disaster situations or covering logistics support. However, in the framework of these operations, problems have arisen due to the absence of having adequate vessels for navigation in shallow waters. To combat the problem, the ARC and the Administrative Department of Science, Technology and Innovation (MINCIENCIAS) have designated resources for Science and Technology Corporation for Naval, Maritime and Riverine Industry Development (COTECMAR) and Colombian Naval Academy (ENAP) to carry out research for the design of a new prototype vessel called BALC-L (Light Boat Logistic Support Vessel) that will meet the needs of logistics and disaster response. This paper focuses on studying and analyzing the behavior of the BALC-L ship in shallow waters, coastal areas and deep-water operations by means of numerical simulation, in order to know its movements and operational limitations under these conditions. This research presents a theoretical introduction, numerical simulation results and the validation of the data obtained from maneuverability and behavior at sea.
Análisis empírico de las causas de la inflación en Colombia durante el periodo 2005-2015
Authors: Rojas Velásquez Libardo , Cerquera Losada Óscar Hernán
Published: February 2022

Este artículo analiza empíricamente las causas de la inflación en Colombia, tomando como punto de referencia las principales escuelas de pensamiento económico que han aportado a este debate. Para ello, se realizan estimaciones econométricas con una muestra de variables económicas y no económicas observadas durante el periodo 2005-2017. Los resultados de las estimaciones muestran que variables macroeconómicas como la masa monetaria, el crecimiento económico, la brecha del producto y la tasa representativa del mercado, tienen un efecto positivo y estadísticamente significativo sobre la inflación. Así mismo, se halla evidencia empírica de la curva de Phillips aumentada y del impacto del fenómeno del niño sobre el nivel general de precios.
Particular features of angiogenesis in lesions in patients suffering from basal cell epithelioma
Authors: Khlebnikova A. N. , Novoselova N. V.
Published: February 2022

Basal cell epithelioma is one of the most frequent malignant skin neoplasms. Angiogenesis plays an important part in the development of basal cell epithelioma. The article presents a review of the angiogenesis of this tumor with the help the immunohistochemistry analysis using CD31 and CD34 markers. The authors established a reliable relationship between the number of vessels expressing CD31 and those expressing CD34 in the superficial and nodular forms of the tumor as well as superficial, multi-center, nodular and infiltrative basal cell epitheliomas. A comparison of the number of vessels expressing CD31 and CD34 markers in different histological types made revealed a trend to their growth in the infiltrative type vs. superficial, multi-center and nodular ones.
Features of matrix metalloproteinase-2 expression in the nuclei of tumor cells of a skin melanoma
Authors: Aksenenko M. B. , Ruksha T. G.
Published: February 2022

Goal of the study. To compare expression of matrix metalloproteinase-2 (MMP-2) in the nuclei and cytoplasm of tumor cells and assess the mutual relation between the localization of MMP-2 expression and different clinical and morphologic criteria in patients with a skin melanoma. Materials and methods. Tumor samples obtained from paraffin blocks taken from patients suffering from a skin melanoma and treated at the Krasnoyarsk Territorial Oncologic Dispensary served as the object of the study. Skin tissue samples taken from patients suffering from a skin melanoma (n = 44) were obtained from the Krasnoyarsk Territorial Pathological Anatomy Bureau. Immunohistochemistry was performed based on a standard technique using primary anti-matrix metalloproteinase-2 antibodies. Results. MMP-2 expression was revealed in the nuclei of tumor cells of a skin melanoma in 43.1% of cases and in the cytoplasm in 56.9% of cases. No significant differences in MMP-2 expression in the nuclei and cytoplasm were revealed (p = 0.33). Patients with nuclear expression in tumor cells are characterized by a more favorable prognosis than patients with cytoplasmic enzyme expression in tumor complexes. No dependence of the intracellular localization of MMP-2 expression on the patient sex or age, tumor localization, Clark level of invasion, Breslow’s thickness, particular features of tumor lymphocyte infiltration, tumor growth phase, histological subtype, pigmentation, tumor ulceration and tumor stage according to AJCC (American Joint Committee on Cancer) was revealed. Conclusion. MMP-2 located in the nuclei can be related to hypoxia in the tumor tissue as well as increased peroxynitrite level, which, in its turn, can have an effect on the function and regulation of matrix metalloproteinases. Moreover, MMP-2 with an atypical localization can be related to tumor cells with different biological characteristics within the same tumor, which characterize the intratumoral heterogeneity of neoplasms. The biological and clinical role of changes in the intracellular localization of the enzyme needs further explanation.
Form № 089/u-kv as the main tool of statistical accounting dermatovenereologist: basics of proper registration
Authors: Juchkov M. V. , Tarasova M. A. , Sonin D. B.
Published: February 2022

An integral part of the physician practices in modern conditions is the proper design and provision of appropriate scientific accounting and reporting of statistical information. One of the main tools of statistical accounting in dermatovenerology is the form № 089/u-kv. This account form of statistical observations in the practice of dermatologist, as well as other professionals who have the right to provide it, always causes some difficulties in the process of clearance and the order of granting. Accordingly the intention of this article is the explanation of certain provisions of guidelines for completing the form № 089/u-kv.
Current methods of non-invasive diagnostics of skin melanoma
Authors: Malishevskaya N. P. , Sokolova A. V.
Published: February 2022

Malignant skin neoplasms including melanoma are now occupying the leading positions in the list of cancer pathologies in Russia, a number of European countries and United States. The percentage of melanoma is less than 4% of the total number of skin neoplasms but melanomas account for up to 80% of lethal cases caused by malignant skin neoplasms. Due to the aggressive nature of melanomas including the proliferative reaction to any invasions including diagnostic ones, there is an urgent need in a reliable non-invasive method to differentiate melanomas from other skin neoplasms and diagnose it at an early stage. This review article discloses descriptions, potential, advantages and shortcomings of non-invasive melanoma diagnostics methods: dermatoscopy, SIAscopy and confocal microscopy. Based on the results of the review, the authors made a conclusion that the development of an algorithm of diagnostics taking into account individual clinical and medical history data, results of non-invasive visualization methods and laboratory test results (proteome analysis, tumor markers) would help to overcome the shortcomings of each individual method, diagnose melanomas at early stages and, respectively, personalize the approach to management for each patient.
T* reatment of vulgar and plantar warts
Authors: Khlebnikova A. N. , Seleznyova Ye. V. , Dorokhina O. V.
Published: February 2022

The article presents data on clinical forms of warts associated with different types of human papillomavirus. The authors analyze the following wart treatment methods: excision, chemical and immune. Based on literature sources, the authors assess the efficacy, advantages and disadvantages of well-known treatment methods. The authors describe their own experience of treating primary and recurrent vulgar and plantar warts with an up-to-date chemical destruction drug - Mardil Zinc Max, a solution containing a complex compound of 1.5% zinc 2-chloropropionate in 2-chloropropionic acid. The efficacy of treatment of vulgar warts was 100%, and that of plantar ones - 62.5%. Clinical recovery was observed both in case of primary and recurrent processes. The treatment had no adverse effects or complications and was characterized by a low injury rate, good tolerance and full tissue recovery without any cosmetic defects.
Current standards for syphilis treatment: comparing the russian and foreign guidelines (part II)
Authors: Krasnoselskikh T. V. , Sokolovskiy E. V.
Published: February 2022

The introduction of penicillin has been a breakthrough in the treatment of syphilis. For 70 years, penicillin remains the preferred drug for the treatment of all forms of the disease; its effectiveness has been proven by wide experience gained from clinical observations. However, a very limited number of published meta-analyzes, systematic reviews and data from randomized controlled trials on the comparative assessment of the effectiveness of various antibiotics and treatment regimens are currently available. Some aspects of syphilis treatment are insufficiently developed, particularly, the treatment schedules for neurosyphilis, syphilis in pregnancy, syphilis in HIV-infected individuals and persons allergic to penicillin. There are disagreements in the assessment of the clinical significance of serofast state after a course of antibiotic therapy. There is no uniform approach to the management of patients with treatment failures. This article compares the Russian standards for syphilis treatment set out in the «Federal guidelines for the management of patients with syphilis» with the current European recommendations of the International Union against Sexually Transmitted Infections (IUSTI) and the recommendations of the US Centers for Disease Control and Prevention (CDC). The peculiarities of these guidelines, their strengths and shortcomings, as well as controversial issues of syphilis therapy are discussed. The differences between the domestic and foreign recommendations are more significant in the section concerning the treatment of syphilis than in the section of diagnosis.
Genetic variability of genital mycoplasmas and its clinical value
Authors: Plakhova K. I.
Published: February 2022

The article presents data on genetic variability of genital mycoplasmas. The author presents the results of genetic variability studies for M. hominis, gene vaa, U. parvum, gene mba, and M. genitalium, gene mg192, sampled from women with different clinical manifestations of inflammatory diseases of the urogenital system. Based on the molecular typing results for 138 samples of genital mycoplasmas, the author revealed a relationship between clinical manifestations of inflammatory diseases of the urogenital system caused by U. parvum and different U. parvum serovars as well as different genetic variations of M. hominis.Infection with 6 U. parvum serovar results in the development of inflammatory diseases of the urogenital tract accompanied by subjective manifestations (р < 0.05). Genetic variant II of М. hominis was revealed more often in patients with clinical manifestations of inflammatory diseases while variant I was revealed more often in patients infected with М. hominis without any signs of inflammation (р < 0.05). Genetic variants of M. genitalium were determined; no significant differences in terms of their prevalence in the examined patients were revealed.
A case of tertiary syphilis manifested with multiple skin gummas
Authors: Krasnoselskikh T. V. , Mikheev G. N. , Grigorian A. E. , Yastrebov V. V. , Sokolovskiy E. V.
Published: February 2022

The tertiary cutaneous syphilis has become extremely rare as a result of the effective treatment of early syphilis with penicillin and occasional antibiotic therapy for concomitant infections. We report a case of tertiary gummatous syphilis associated with asymptomatic neurosyphilis that was initially misdiagnosed as basal cell carcinoma of the skin. A 67-year-old woman presented with the 18-month history of multiple, firm, bluish-red asymptomatic nodes on the parietal scalp, chin and lateral part of the trunk that had developed without preceding trauma. One node on the trunk had small central ulceration covered with dry yellowish crust. On the left retroauricular area the brownish-purple atrophic scar was observed. Blood tests revealed reactive VDRL, ELISA and TPHA assays. Skin biopsy has showed endarteritis with endothelial swelling and caseating granulomas along with plasmocytic infiltrate in the dermis and subcutaneous tissue. Increased lymphocyte count and the positive VDRL test with cerebrospinal fluid have confirmed the diagnosis of asymptomatic syphilitic meningitis in this patient. The treatment with aqueous penicillin intravenously has lead to resolution of the skin infiltrates and progressive more than 4-fold reduction of follow-up serum VDRL titers. This case is reported as a reminder of the possibility of tertiary syphilis with misleading clinical patterns in patients infected during the epidemics of 1995-2000. We would like to emphasize the necessity to perform timely serological and pathomorphological study to prevent misdiagnosis and mistreatment.
Rosacea: prevalence, pathogenesis, particular features of clinical manifestations
Authors: Kubanova A. A. , Makhakova YU. B.
Published: February 2022

This literature review examines principal aspects of rosacea prevalence in the Russian Federation and abroad, shows present-day opinions about the pathogenesis and histological picture of rosacea and presents actual classification and a number of key clinical forms of the disease.
Rosacea: diagnostics and treatment
Authors: Kubanova A. A. , Makhakova Yu. B.
Published: February 2022

The authors present current data from the literature relating to major characteristics and efficacy of methods of non-invasive diagnostics of rosacea (dermatoscopy, dopplerography, ultrasound scanning, confocal laser scanning microscopy) as well as aspects of a systemic external therapy, laser therapy and use of IPL systems in the treatment of patients suffering from rosacea.
The clinical case of Sneddon - Wilkinson disease in a pregnant woman
Authors: Askhakov M. S. , Chebotarev V. V. , Odinec A. V.
Published: February 2022

Describes a rare clinical case demonstrating the sudden appearance of the disease Sneddon - Wilkinson in women during pregnancy, which regressed completely within a month after birth and had no recurrence.
Efficiency research of the comprehensive hair loss treatment
Authors: Kubanov A. A. , Galljamova J. A. , Selezneva O. A.
Published: February 2022

Scope. To determine the therapeutic potency of telogen effluvium complex therapy and androgenetic alopecia. Materials and methods. There are presented results on treatment of 45 patients with telogen hair loss (15 women) and androgenetic alopecia (15 men and 15 women) who were divided into two groups depending on the method of treatment: the main group and the control group. Patients of the main group got pharmaceutical treatment (homeopathic medicine, a L-cysteine + B vitamins preparation) and local therapy (biomimetic peptides-based lotion on the skin of the hairy part of head). The patients in the control group received a similar pharmaceutical treatment but with no applying of biomimetic peptide lotion to the skin of the hairy part of head (scalp). Before and after the therapy the computer-assisted hair and scalp diagnostics were conducted to the fixed zones with permanent marks. The overview photographs of the scalp before the treatment and at follow-up visits were made for the purpose of the follow-up clinical performance evaluation. Results. The computer-assisted hair and scalp diagnostics results analysis of the patients in the study and control groups proved the complex alopecia treatment to be effective.
Modern demodicosis diagnostics methods
Authors: Kubanov A. A. , Galljamova J. A. , Grevtseva A. S. , Gribanov N. V.
Published: February 2022

An overview of the modern demodicosis diagnostics methods and in-house demodicosis diagnosis with intravital laser scanning confocal microscopy effectiveness studies. The study included 60 patients with acne and rosacea, complicated demodicosis, 60 patients with acne and rosacea and no demodicosis, and 30 healthy volunteers. All the patients underwent skin scraping, eyebrows and/or eyelashes hair removal and confocal laser-scanning microscopy. the advantages of confocal laser-scanning microscopy in vivo in comparison with conventional methods of research are shown.
Influence of natural factors Saki lake combined with “Berlition® 600” (Thioctic acidi) on immunoregulatory processes taking into account morphological changes of skin in patients with plaque psoriasis
Authors: Kuznetsova M. YU. , Pritulo O. A. , Prokhorov D. V.
Published: February 2022

Objective. To study the effect of peloids Saki Lake and brine, combined with the drug “Berlition® 600” on immunoregulatory processes based on morphological and functional changes of the skin in patients with plaque psoriasis. Materials and methods. The study involved 90 patients with plaque psoriasis mild to moderate severity. The study group included - 45 patients receiving therapeutic mud treatments, and the brine baths in conjunction with the “Berlition® 600” in the control group - 45 patients treated with mud baths and RPMA. All patients using flow cytometry laser defined subpopulations of T-lymphocytes. The concentration of Ig A, M and G in the blood was determined by mikroturbidimetricheskim with monospecific antisera; proinflammatory and anti-inflammatory cytokines (IL-1a, IL-2, IL-8, IL-10, TNF-α) was measured by enzyme-linked immunosorbent assay (ELISA). Immunohistochemistry Skin biopsy were studied with the definition of CD3+, CD4+, CD8+ T-lymphocytes. Results and discussion. Patients in both treatment groups revealed an imbalance of T and B-cell immunity to the reduction in the number of helper-inductor (CD4+) and cytotoxic (CD8+) subpopulations of T-L in peripheral blood and increase in CD3+, with a predominance of CD8+ in psoriatic infiltrate amid overproduction of cytokines. Procedures for medical mud and the brine baths in combination with the drug “Berlition® 600” has a marked immunomodulatory effect due normalitsatsiey of T-cell immunity and reduction of the balance of cytokine profile, “clinical cure” and “significant improvement” reached 45 (100%) patients, the index regression PASI- 96,7 ± 1,3% DLQI-86 ± 2,1%. Conclusions. Peloids, balneotherapy in Lake Saki in combination with the drug “Berlition® 600” has a high clinical efficacy due to immunomodulatory, antiproliferative and anti-inflammatory effects and can be recommended as a differentiated, immunomodulatory therapy in patients with plaque psoriasis mild to moderate severity.
Potential of confocal laser scanning microscopy for non-invasive diagnostics of malignant epithelial skin tumors in the course of dermatoheliosis progression
Authors: Snarskaya E. S. , Tkachenko S. B. , Kuznetsova E. V. , Allenova A. S.
Published: February 2022

Most cases of malignant epithelial skin neoplasms including actinic keratosis and basal cell carcinoma, which are characterized by the most complicated course and numerous clinical and morphological options, involve dermatoheliosis progression. The risk of actinic keratosis transformation into basal cell carcinoma varies from 0.1% to 20% and up to 80% in cases of multiple AK lesion foci. A non-invasive method known as reflectance confocal laser scanning microscopy is the most promising one for the purposes of early diagnostics of signs pointing at epithelial skin neoplasm development and makes it possible to monitor the tumor in progress in vivo to diagnose the presence of a pool of squamous cells on a timely basis. The confocal laser scanning microscopy method provides high-contrast images of for any horizontal-oriented morphologic structures in the epidermis and upper dermis with a resolution comparable to those characteristic of traditional optical microscopy of skin tissue samples. According to our data obtained as a result of studying dynamic changes and morphologic structures in actinic keratosis foci (50 cases) using the confocal laser scanning microscopy method, we discovered a number of morphologic features, and their further analysis will distinguish the signs of progressing carcinogenesis in case of dermatoheliosis.
A case of localized bullous scleroderma
Authors: Bakulev A. L. , Galkina E. M. , Karakaeva A. V. , Litvinenko M. V.
Published: February 2022

Bullous scleroderma is a rare type of the focal form of the disease mainly affecting the skin and characterized by induration and sclerosis foci as well as subepidermal blisters containing a transparent matter. The article describes a case study of bullous scleroderma in an adult woman with localized skin eruptions in the area of the left breast, which were completely regressed after a standard therapy with the use of drugs having an effect on collagen synthesis.
Disseminated induced pseudolymphoma DTP vaccine
Authors: Harchilava M. G. , Atayan E. A. , Benedik N. A. , Hayrutdinov V. R. , Belousova I. E. , Samtsov A. V.
Published: February 2022

This article considers the variant of disseminated vaccine-induced pseudolymphoma (VIP), which appeared after the introduction of the DTP vaccine. The article describes features of the observed case: common skin rashes affecting the skin of the face, left and right shoulder, chest and upper back. The effectiveness of topical corticosteroids, calcineurin inhibitors and intralesional injections of betamethasone dipropionate and betamethasone sodium phosphate solution has been shown.
Lamellar congenital ichthyosis in practice of dermatologists
Authors: Koshkin S. V. , Chermnykh T. V. , Evseeva A. L. , Ryabova V. V. , Ryabov A. N.
Published: February 2022

The paper describes 2 cases of congenital lamellar ichthyosis debuting state «collodion baby». Presented features of clinical manifestations: in newborn all skin is covered with a thin dry yellowish-brown film, resembling collodion, also ectropion and eklabium are frequently marked. After some time cracks appear, the film turns into large squamas, which exfoliate completely in 1.5 months, and so the clinical picture of congenital ichthyosis is formed. Timely initiated therapy, including external moisturizers and lipid-replenishing funds, contributed to the rapid relief of clinical symptoms and infectious-inflammatory process.
Strategy for managing patients with severe cases of rosacea
Authors: Sergeyeva I. G. , Krinitsyna Yu. M.
Published: February 2022

The article presents 3 clinical observations of women of 51, 55 and 57 years old with severe rosacea, who reached the state of remission after a prolonged course of systemic therapy with low doses of isotretinoin. Cumulative dose of isotretinoin for persistent clinical remission was 46.4 mg/kg of weight, 17.6 mg/kg, 12.6 mg/kg respectively. Difficulties related to the subjective perception of patients of his condition has limited the possibility of increasing daily dose of isotretinoin, and the lack of result from the previous therapy with basic medications has made isotretinoin a drug of choice.
Squamous cell carcinoma of penis in patient with incipient neurosyphilis
Authors: Zaslavsky D. V. , Egorova Y. S. , Chuprov I. N. , Fedorchenko A. B. , Mareha G. L. , Fomenko M. N. , Gurkovskaya Y. Y. , Parxomenko S. I. , Timoshchuk E. A. , Kozlova L. I. , Sidikov A. A.
Published: February 2022

Squamous cell carcinoma of the skin (SSCC) is one of the most common malignant skin tumors. Syphilis is a sexually transmitted disease caused by Treponema pallidum, with human beings as the only host. The combination of syphilis and squamous cell carcinoma of the skin is not uncommon, particularly if the lesions are located on different parts of the body. However, simultaneous development of the chancre and squamous cell carcinoma of the glans penis seems exceptional. Considering rarity of the manifestation observed we feel the rare case of combined syphilis and squamous cell skin cancer is of interest.
Diagnosis of actinic keratosis by dermatoscopy
Authors: Khlebnikova A. N. , Obydenova K. V. , Sedova T. G. , Andrukhina V. V.
Published: February 2022

Introduction: Actinic keratosis (AK) is a local introepidermal atypia of keratinocytes, formed as a result of intense and prolonged exposure to sunlight. AK lesions located on exposed areas of skin, mostly on the face, in this regard, a more relevant non-invasive diagnostic techniques, primarily dermatoscopy. Material and methods: We examined 35 patients and revealed they have 204 hearth. Results: Of the 204 lesions erythematous form was found in 160 (78, 4%) cases, keratotic - 24 (11,8%), pigmental (9.8 %). Patients with AK most private dermatoscopic signs were erythema (90,2%), vascular structures (67,65%), keratin scales (51,47%), pseudonetwork (23,04%). Discussion: Analyzing dermoscopic picture of the most common forms of AK met the characteristics for each shape. A detailed study of vascular structures allows for the differential diagnosis of cancer in situ. While AK watched point and the glomerular vessels of not more than 10% of cases, which helped to differentiate AK from cancer in situ, in which such vessels were found in 40%. Glomerular vessels are not met in our study and the points were only 2.45% of the cases. Keratotic AK was characterized in 100% of cases the presence of keratin scales. In pigment form, we revealed the dark brown streaks (80%), dark brown points (50%), brown globules (30%), dark brown blots (10%) and slate-grey dots (10%). But the gold standard for the differential diagnosis with maligna lentigo is a morphological study. Conclusion: AK has specific characteristics in treatment research, which helps to differentiate it from other benign and malignant tumors of the skin, and to diagnose it in its earliest stages without resorting to invasive procedures. Effective diagnosis of AK reduces the risk of malignant transformation and contribute to the selection of adequate and necessary treatment tactics.
New potential of the complex therapy of anogenital papilloma viral infection
Authors: RAKHMATULINA M R
Published: February 2022

The article covers issues of etiology and pathogenesis of papilloma viral infection as well as current concepts of the role of immune mechanisms in the development of an infectious process. It also presents the results of a comparative clinical study of the efficacy and safety of Ingaron (γ-interferon) in the complex therapy of anogenital papilloma viral infection.
Treatment of vulvovaginites caused by opportunistic microorganisms. Current concepts and efficacyassessment
Authors: Shatalova A Yu , Shatalova A Yu
Published: February 2022

The author describes current approaches to treatment of vulvovaginites caused by opportunistic microorganisms.
The author assessed clinical and microbiological efficacy of different methods of treatment used for this pathology.
Skin ultrasound examination in the cosmetologists practice
Authors: Bezuglyy A P , Bikbulatova N N , Shuginina E A , Belkov P A , Khabutdinova N R , Bezuglyi A P , Bikbulatova N N , Shuginina Ye A , Belkov P A , Khabutdinova N R
Published: February 2022

The article presents the study results for available options as well as diagnostics value and limitations related to skin ultrasound scans in medical cosmetology. The authors applied the skin ultrasound scanning method at 22 MHz and 75 MHz to visualize the structure of epidermis, derma and subcutaneous cellular tissue. Patients with chronic inflammatory dermatoses, skin neoplasms, cicatrical changes and age-related skin changes made a part of the sample under examination. The authors obtained scanograms of the skin structure and used them to measure the depth of different skin layers and formations as well as tissue echodensity. The qualitative and quantitative data were applied to specify the clinical diagnosis and assess the treatment efficacy.
Family case of hystriciasis
Authors: Kondrat'eva Yu S , Safonov N E , Kleymush V A , Shipilov A A , Kondratiyeva Yu S , Safonov N Ye , Kleimush V A , Shipilov A A
Published: February 2022

The authors describe a rare case of family hystriciasis in a mother aged 35 and her children (son aged 7 and daughter
aged 4). A review of literature from Russian and foreign sources is given.
Current approaches to the external therapy of photodermatoses
Authors: Khlebnikova A N , Khlebnikova A N
Published: February 2022

Remedial measures for photodamages of skin are mainly aimed at elimination of inflammation and subjective sensations
such as burning and itching. Topical corticosteroids remain leading drugs in the external therapy of phototrauma,
phototoxic and photoallergic reactions. Mometasone furoate (Elocom) has high anti-inflammatory and antiallergic
activity. Moreover, the composition of the Elocom cream is based on titanium dioxide, a classical mineral screen,
which makes it possible to use the Elocom cream in case of steroid-sensitive pathology under conditions of high solar
exposure. The Elocom cream has been used in the monotherapy and complex treatment of solar dermatitis, actinic
cheilitis, polymorphous light eruption, discoid lupus erythematosus and actinic prurigo. Regression of manifestations of
solar dermatitis was recorded on Day 1-3 of treatment, and regression of manifestations of actinic cheilitis - during
Week 2 of treatment. The process in case of photoallergic reactions and discoid lupus erythematosus was over during
Week 3-4 of treatment. Substances making a part of the composition of the Elocom cream and having photoprotective
properties make this cream a drug of choice for its use on skin areas subject to solar exposure in case of steroidsensitive
pathology including phototrauma, phototoxic and photoallergic reactions. Besides, photoprotective properties
of the Elocom cream explain why it should be selected for treatment of steroid-sensitive dermatoses becoming more
severe or appearing after solar exposure, in case of localization of eruptions on open skin areas (face, neck, decollete
area, hands, etc.)
Clinical efficacy, safety and tolerance of clindamycin phosphate gel, 1%, in the treatment of mild tomoderate acne
Authors: Samtsov A V , Sukharev A V , Bondar' O I , Patrushev A V , Nazarov R N , Minchenko A A , SAMTSOV A V , SUKHAREV A V , BONDAR O I , PATRUSHEV A V , NAZAROV R N , MINCHENKO A A
Published: February 2022

The authors present the results of a prospective, open-label, post-registration comparative study of the monotherapy
of mild to moderate acne with an inflammatory component. 30 subjects aged 15-35 were engaged in the study.
Subjects from Group 1 (n = 15) received Clindovit® in the form of 1% gel, and subjects from Group 2 (n = 15) received
a combination of erythromycin and zinc in the form of lotion. The duration of treatment and participation in the study
was 8 weeks. Dynamics of clinical manifestations of the disease, Dermatology Life Quality Index (DLQI), Psychological
and Social Effects of Acne (APSEA), frequency and severity of adverse events against the background of treatment
were assessed. The results of the study enabled the investigators to make a conclusion about efficacy, safety and good
tolerance of Clindovit® gel as a monotherapy of mild to moderate acne with an inflammatory component.
Scalp psoriasis: new potential of the topical therapy
Authors: Bakulev A L , Kravchenya S S
Published: February 2022

Clobetasol propionate is a potent topical corticosteroid that is widely used for the treatment of scalp psoriasis today. The review provides data obtained as a result of numerous clinical studies meeting the requirements of evidence-based medicine concerning the efficacy and safety of a new drug form — Clobetasol Propionate 0.05% Shampoo. Its short-term administration arrests exacerbations of dermatosis while a long-term proactive therapy prevents the development of new psoriatic eruptions on the sculp. Such issues as cosmetic acceptability and compliance of Clobetasol Propionate Shampoo for patients suffering from the scalp psoriasis are discussed.
Hospitalization replacement technologies in the Russian Federation
Authors: Butareva M M
Published: February 2022

The article presents data on different forms of hospitalization replacement technologies in foreign countries and in the Russian Federation. The author describes an experience of administering medical aid according to individual profiles under the conditions of hospitalization replacement technologies.
Production and evaluation of the clinical efficacy of the recombinant T. pallidum antigen Tp0453 for syphilis diagnosis
Authors: KHAIRULLIN R F , RUNINA A V , ROG K V , FRIGO N V , ROTANOV S V
Published: February 2022

Goal. Production of a recombinant T. pallidum antigen Tp0453 and the evaluation of the efficacy of its clinical use for syphilis diagnosis. Materials and methods. To produce the target recombinant T. pallidum antigen, a Tp0453 protein coding fragment of the DNA of the causative agent of syphilis, was cloned into the pET28а vector. Heterological expression of the recombinant T. pallidum antigen was performed in the E. coli BL21 (DE3) strain. The recombinant Tp0453 six-histidine-tagged protein was purified by the metal-chelate affinity chromatography. The resulting homogenous recombinant T. pallidum Tp0453 protein was used to reveal specific IgG antibodies in the serum of syphilis patients using a microarray technology. Results and conclusion. The use of the resulting recombinant protein enabled authors to reveal anti- T. pallidum antibodies in the blood serum of patients suffering from syphilis (primary, secondary, early and late latent syphilis). None of the uninfected controls had a significant reactivity to the recombinant Tp0453. These data allow to propose, that the recombinant protein Tp0453 show promise for laboratory diagnosis of syphilis. The introduction of Tp0453 antigen into the test systems for diagnosis of syphilis (ELISA, immunoblotting or microarray) increases the potential of serodiagnosis of this disease due to the broader range of the revealed antitreponemal antibodies.
Comparative research of clinical efficience of 3% TeTracycline ointment and 2% of mupirocin ointment in pyoderma therapy
Authors: SAMTSOV A V , STATSENKO A V , HAIRUTDINOV V R , CHAPLYGIN A V
Published: February 2022

Pyodermas are infectious skin diseases, prevailing in morbidity patterns of all categories of RF military men. The optimal etiotropic substance for the treatment of pustular diseases is carried out, while taking into consideration the data on excitors’ sensitivity. Mupirocin is a topical antibacterial substance, which activity is equivalent to the activity of peroral antibiotics Target - Migrative evaluation of the efficiency of 3% of tetracycline ointment and 2% of mupirocin ointment (supirocin) in the treatment of patients with pyoderma. Маterial and methods. 60 patients with initial pyodermas were examined, before and after the course of treatment the bacteriological research of erosions’ secretion was performed. Patients were undergoing the monotherapy with topical antibacterial substance 2 times a day: 2% mupirocin ointment in the 1st group and - 3% of tetracycline ointment in the 2nd group. After the regress of eruptions terms and efficiency of the treatment were assessed. Results. The topical antibacterial therapy of pyodermas with 2% mupirocin ointment is more effective than with 3% tetracycline ointment, - 40 (100%) of patients against 16 (80%) of patients, (р < 0,01). The use of 2% mupirocin ointment allows to decrease considerably terms of treatment of patients with pustular skin diseases in comparison with application of 3% tetracycline ointment (8,1 ± 1,8 and 12,2 ± 3,2 days accordingly, р < 0,01). 2% mupirocin ointment has got high clinical efficiency and can be recommended for the therapy of patients with pyodermas.
Pathogenesis and treatment of acne at women’s hyperandrogenism syndrome
Authors: GRODNITSKAYA E E , KURTSER M A
Published: February 2022

Аспе is one of most spread people’s disease and is characterized by the piloseboceial complex affection. Acne pathogenesis is a multifactor one, and the hyperandrogenism favors the disease development. The article highlights the acne pathogenesis, discusses methods of the endocrinologic examination and treatment of women’s hyperandrogenism.
Bioinformatic analysis of T. pallidum specific antigens
Authors: KHAIRULLIN R F , ROTANOV S V , FRIGO N V , BELOUSOVA A V
Published: February 2022

Using bioinformatics methods (PSI-BLAST, PSORTb, Cello, BOMP, TMBETADISC-PSSM, TMHMM, LipoP, UiB Lipo, SignalP servers), the authors analyzed sequences of fifteen T. pallidum proteins, which may be potential antigens for the diagnostics of the syphilitic infection. They revealed that Tp0259, Tp0453, Tp0608, Tp0326, Tp0249, Tp0136 and Tp0684 proteins may be promising for further studies.
Indices of work quality for specialized medical institutions of the dermatovenerology profile aimed at syphilis diagnostics (a review of literature)
Authors: FRIGO N V , ROTANOV S V , KUBANOV A A , SKOPETSKAYA T V , MANUKIYAN T YE , NEGASHEVA YE S
Published: February 2022

The authors present the results of a study of literature sources for such indices as assessment of the efficacy and quality of medical services in medical care institutions based on quantitative parameters being quality indices. The authors demonstrate that indices for assessing the quality of work at medical institutions can involve information about materials, technical and other resources and personnel available at institutions, state statistics accounting forms, data from information and analytical systems and patient registers as well as additional indices developed by experts. Incidence indices are currently the key indicator for assessing the work quality of institutions dealing with syphilis diagnostics. No indicators and criteria for assessing the quality of laboratory assistance rendered to syphilitic patients have been developed yet.
Current concepts of the epidemiology, clinical picture, diagnostics and therapy of non-complicated and complicated forms of the urogenital chlamydia infection in men
Authors: RAKHMATULLINA M R , POPOV D V , PLAKHOVA K I
Published: February 2022

The authors present the results of recent studies of the epidemiology and immunopathogenesis of non-complicated and complicated forms of the urogenital chlamydia infection in men. They also present the results of a study of clinical features of the chlamydia infection and describe up-to-date diagnostics and treatment methods.
Pathogenic therapy of acne patients
Authors: VOLKOVA YE N , GRIGORIYEVA A A , YELISTRATOVA I V
Published: February 2022

The authors provide a detailed description of the composition, pharmacokinetic and pharmacodynamic properties of Acnecutan, an innovation drug for the system pathogenic therapy of acne. They present the results of clinical observations and treatment of 88 patients suffering from moderate to severe acne forms with Acnecutan.