bluuebunny/crossref_metadata_2025 huggingface dataset:
ZAP-70 mutation: a case with familial autoimmune haemolytic anaemia and immune deficiency
Authors: Abd Elhamed Mai M , Wali Yasser , Youssry Ilham
Published: March 2024

Zeta-chain associated protein kinase 70 kDa (ZAP-70) deficiency is one of the rare immunodeficiency disorders due to autosomal recessive homozygous or compound heterozygous loss-of-function mutations in the ZAP-70GENE. In the literature, patients with ZAP-70 deficiency have been reported with a broad spectrum of clinical manifestations including recurrent respiratory infections (81.8%), cutaneous involvement (57.9%), lymphoproliferation (32.4%), autoimmunity (19.4%), enteropathy (18.4%) and increased risk of malignancies (8.1%). The most common immunological phenotype in those patients was low CD8+ T cell counts (97.9%) and normal non-functioning CD4+ T cell. Haematopoietic stem cell transplantation was applied as a curative treatment for this disorder.
Sex-specific effects of frailty on cardiac structure and function: insights from preclinical models
Authors: Bisset Elise S. , Howlett Susan E.
Published: March 2024

Advanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a major risk factor for cardiovascular disease and predicts adverse outcomes in those affected. Recent studies in mouse models of frailty show that many adverse changes associated with cardiac aging are more prominent in mice with a high degree of frailty. This suggests that frailty sets the stage for late life cardiovascular diseases to flourish and raises the possibility that treating frailty may treat cardiovascular diseases. These studies show that ventricular dysfunction increases with frailty in males only, whereas atrial dysfunction increases with frailty in both sexes. These results may shed light on the reasons that men and women can be susceptible to different cardiovascular diseases as they age, and why frail individuals are especially vulnerable to these disorders.
The Low soft-photon theorem again
Authors: Fadin V. S. , Khoze V. A.
Published: March 2024

It is shown that contrary to claims of Lebiedowicz et al. (Phys Rev D 105(1):014022, 2022) the formulated in the proper physical variables Low theorem (Low in Phys Rev 110(4):974–977, 1958) for soft photon emission does not require any modification. We also reject the criticism in Lebiedowicz et al. (2022) of the papers (Burnett and Kroll in Phys. Rev. Lett. 20:86–88,1968; Lipatov in Nucl Phys B 307:705–720, 1988). At the same time, we identify some inaccuracies in Burnett and Kroll (1968) in the presentation of the soft-photon theorem for the case of spin-one-half particles. We also point out shortcomings in consideration of the Low theorem in the classic textbooks (Berestetskii et al. in Quantum electrodynamics. Pergamon Press, Oxford, 1982; Lifshitz and Pitaevsky in Relativistic quantum theory, part 2, Fizmatlit, 2002).
Multiple soliton, soliton molecules and the other diverse wave solutions to the (2+1)-dimensional Kadomtsev–Petviashvili equation
Authors: Wang Kang-Jia , Shi Feng , Xu Peng
Published: March 2024

The central purpose of this paper is to explore the nonlinear dynamics of the (2+1)-dimensional Kadomtsev–Petviashvili equation (KPE). The multiple soliton solutions (MSSs) are constructed via applying the Hirota method. Then the soliton molecules on the ([Formula: see text]-, ([Formula: see text]- and ([Formula: see text]-planes are extracted via imposing the velocity resonance conditions to the MSSs. Eventually, two effective techniques, the sub-equation approach (SEA) and the variational approach (VA), are employed to probe some other diverse wave solutions, which are the bright wave, dark wave, singular wave and the singular periodic wave solutions. The dynamics of the extracted solutions are unveiled graphically to exhibit the physical attributes. The attained solutions in this paper can enlarge the exact solutions of the (2+1)-dimensional KPE and enable us to understand the nonlinear dynamic behaviors better.
Numerical simulation of molybdenum disulfide-carbon nanotubes/water hybrid nanofluid flow due to a stretching cylinder: Applications to industrial manufacturing processes
Authors: Reddy M. Gnaneswara , Latha K. Bhagya Swetha , Verma Anjali , Ramesh Katta
Published: March 2024

This study delves into the exploration of hybrid nanofluids within the context of a stretching cylinder, a domain that has captivated numerous researchers owing to its pivotal applications in industrial manufacturing processes, particularly in metal forming and stretch dies. The authors, recognizing the significance of these applications, have introduced a novel heat transfer fluid termed hybrid nanofluid, comprising molybdenum disulfide and carbon nanotubes suspended in the base liquid, water. The investigation focuses on the flow of the hybrid nanofluid within a stretching cylinder, considering various influential factors such as Joule heating, thermal radiation, porous medium, and magnetic field effects. To model this complex problem, we employed modified Navier–Stokes equations. Employing similarity transformations, assumptions, and non-dimensional parameters, the problem was effectively simplified. The MATLAB bvp4c technique, a well-established numerical approach, was then employed to solve the resulting mathematical formulation. Graphical representations are presented to illustrate various aspects of the flow, facilitating a comprehensive understanding of the system. Comparisons are drawn among the flow characteristics of mono nanofluid, and the developed hybrid nanofluid. It is noted from the current analysis that the temperature strength increases with higher values of the magnetic field parameter, curvature parameter, radiation parameter, and Eckert number in both fluid cases. The Nusselt number increases with higher values of Prandtl number and thermal relaxation parameter. The identified patterns in velocity distribution, temperature strength, and fluid behavior provide a valuable foundation for optimizing thermal efficiency in diverse industrial applications. By leveraging the insights gained from this research, manufacturers can make informed decisions to enhance heat transfer processes, particularly in areas such as metal forming and stretch dies.
On the Darcy–Forchheimer flow of carbon nanotubes nanofluid across a stretching surface for the impact of heat source/sink and Ohmic heating
Authors: Tripathy R. S. , Ratha P. K. , Mishra S. R.
Published: March 2024

This research leads to carrying out the productivity and the efficiency of the carbon nanotubes (CNTs) that have extensive applications in solar collectors. Due to the superior thermal as well as electrical properties, the use of CNTs has an important contribution to the nanotechnology revolution. Therefore, owing to the aforementioned vital points, this investigation intended to put forth the thermophysical properties of both single and multi-walled CNT nanofluids past a stretching surface. Additionally, an electrically conducting nanofluid flow phenomenon enriches due to the inclusion of dissipation (Ohmic heating) and external heat source/sink. The dimensional form of the three-dimensional fluid flow phenomena is transformed to a non-dimensional form with the use of similarity transformation and further numerical procedure is implemented to solve the nonlinear governing equations. The substantial significance of the characterizing parameters is presented briefly via figures and the comparative analysis with the earlier investigation is deployed through the table. However, the main findings of this study are as follows: A significant attenuation in the shear rate is marked for the enhanced inertial drag but it augments for the augmented values of the magnetization; further, particle concentrations of both the CNTs favor accelerating the fluid momentum as well as temperature distribution.
Optimal Maintenance Policies of Wave-Dissipating Blocks Using Cumulative Damage Model
Authors: Nakamura Takahiro , Dong Yunlong , Ito Kodo , Higuchi Yoshiyuki
Published: March 2024

Different types of social infrastructure, such as roads and bridges, are essential and necessary for supporting our daily lives and economic operations. Because 39% of Japan’s road bridges and 27% of its tunnels will have been in use for 50 years or more by 2023, maintaining them has become a significant national concern (Ministry of Land, Infrastructure, Transport and Tourism, White Paper on Land, Infrastructure, Transport and Tourism in Japan (2017), p. 114). Because of the declining birthrate, the deteriorating labor force, and the weakening local economy, the Japanese government must maintain these social infrastructures while facing severe budgetary challenges. And efficient and economical maintenance strategies and plans are required. This paper proposes optimal maintenance policies which consider the unique circumstances of social infrastructure and minimize maintenance costs. By applying these policies to wave-dissipating blocks in Japan, the effectiveness of them is confirmed.
Cooking with Conversation: Enhancing User Engagement and Learning with a Knowledge-Enhancing Assistant
Authors: Frummet Alexander , Speggiorin Alessandro , Elsweiler David , Leuski Anton , Dalton Jeff
Published: March 2024

We present two empirical studies to investigate users’ expectations and behaviours when using digital assistants, such as Alexa and Google Home, in a kitchen context: First, a survey (N = 200) queries participants on their expectations for the kinds of information that such systems should be able to provide. While consensus exists on expecting information about cooking steps and processes, younger participants who enjoy cooking express a higher likelihood of expecting details on food history or the science of cooking. In a follow-up Wizard-of-Oz study (N = 48), users were guided through the steps of a recipe either by an
active
wizard that alerted participants to information it could provide or a
passive
wizard who only answered questions that were provided by the user. The
active
policy led to almost double the number of conversational utterances and 1.5 times more knowledge-related user questions compared to the
passive
policy. Also, it resulted in 1.7 times more knowledge communicated than the
passive
policy. We discuss the findings in the context of related work and reveal implications for the design and use of such assistants for cooking and other purposes such as DIY and craft tasks, as well as the lessons we learned for evaluating such systems.
REC: REtime Convolutional Layers to Fully Exploit Harvested Energy for ReRAM-based CNN Accelerators
Authors: Zhou Kunyu , Qiu Keni
Published: March 2024

As the Internet of Things (IoTs) increasingly combines AI technology, it is a trend to deploy neural network algorithms at edges and make IoT devices more intelligent than ever. Moreover, energy-harvesting technology-based IoT devices have shown the advantages of green and low-carbon economy, convenient maintenance, and theoretically infinite lifetime, and so on. However, the harvested energy is often unstable, resulting in low performance due to the fact that a fixed load cannot sufficiently utilize the harvested energy. To address this problem, recent works focusing on ReRAM-based convolutional neural networks (CNN) accelerators under harvested energy have proposed hardware/software optimizations. However, those works have overlooked the mismatch between the power requirement of different CNN layers and the variation of harvested power.

Motivated by the above observation, this article proposes a novel strategy, called
REC
, that retimes convolutional layers of CNN inferences to improve the performance and energy efficiency of energy harvesting ReRAM-based accelerators. Specifically, at the offline stage,
REC
defines different power levels to fit the power requirements of different convolutional layers. At runtime, instead of sequentially executing the convolutional layers of an inference one by one,
REC
retimes the execution timeframe of different convolutional layers so as to accommodate different CNN layers to the changing power inputs. What is more,
REC
provides a parallel strategy to fully utilize very high power inputs. Moreover, a case study is presented to show that
REC
is effective to improve the real-time accomplishment of periodical critical inferences because
REC
provides an opportunity for critical inferences to preempt the process window with a high power supply. Our experimental results show that the proposed
REC
scheme achieves an average performance improvement of 6.1× (up to 16.5×) compared to the traditional strategy without the
REC
idea. The case study results show that the
REC
scheme can significantly improve the success rate of periodical critical inferences’ real-time accomplishment.
Orchard: Heterogeneous Parallelism and Fine-grained Fusion for Complex Tree Traversals
Authors: Singhal Vidush , Sakka Laith , Sundararajah Kirshanthan , Newton Ryan , Kulkarni Milind
Published: March 2024

Many applications are designed to perform traversals on
tree-like
data structures. Fusing and parallelizing these traversals enhance the performance of applications. Fusing multiple traversals improves the locality of the application. The runtime of an application can be significantly reduced by extracting parallelism and utilizing multi-threading. Prior frameworks have tried to fuse and parallelize tree traversals using coarse-grained approaches, leading to missed fine-grained opportunities for improving performance. Other frameworks have successfully supported fine-grained fusion on heterogeneous tree types but fall short regarding parallelization. We introduce a new framework
Orchard
built on top of
Grafter
.
Orchard
’s novelty lies in allowing the programmer to transform tree traversal applications by automatically applying
fine-grained
fusion and extracting
heterogeneous
parallelism.
Orchard
allows the programmer to write general tree traversal applications in a simple and elegant embedded Domain-Specific Language (eDSL). We show that the combination of fine-grained fusion and heterogeneous parallelism performs better than each alone when the conditions are met.
Distributional Fairness-aware Recommendation
Authors: Yang Hao , Wu Xian , Qiu Zhaopeng , Zheng Yefeng , Chen Xu
Published: March 2024

Fairness has been gradually recognized as a significant problem in the recommendation domain. Previous models usually achieve fairness by reducing the average performance gap between different user groups. However, the average performance may not sufficiently represent all the characteristics of the performances in a user group. Thus, equivalent average performance may not mean the recommender model is fair, for example, the variance of the performances can be different. To alleviate this problem, in this article, we define a novel type of fairness, where we require that the performance distributions across different user groups should be similar. We prove that with the same performance distribution, the numerical characteristics of the group performance, including the expectation, variance, and any higher-order moment, are also the same. To achieve distributional fairness, we propose a generative and adversarial training framework. Specifically, we regard the recommender model as the generator to compute the performance for each user in different groups, and then we deploy a discriminator to judge which group the performance is drawn from. By iteratively optimizing the generator and the discriminator, we can theoretically prove that the optimal generator (the recommender model) can indeed lead to the equivalent performance distributions. To smooth the adversarial training process, we propose a novel dual curriculum learning strategy for optimal scheduling of training samples. Additionally, we tailor our framework to better suit top-N recommendation tasks by incorporating softened ranking metrics as measures of performance discrepancies. We conduct extensive experiments based on real-world datasets to demonstrate the effectiveness of our model.
A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling
Authors: Shang Kuang-Ming , Kato Hiroyuki , Gonzalez Nelson , Kandeel Fouad , Tai Yu-Chong , Komatsu Hirotake
Published: March 2024

Our study introduces an innovative combinatory approach for noninvasively determining the critical survival oxygen level of cells within small cell spheroids, which replicates a 3-D tissue environment, by seamlessly integrating three pivotal techniques: cell death induction under controlled oxygen conditions, semiautomated imaging that precisely identifies live/dead cells, and computational modeling of oxygen distribution. Notably, our method ensures high-throughput analysis applicable to various cell types, offering a versatile solution for researchers in diverse fields.
Divergent selection for feed efficiency in pigs altered the duodenum transcriptomic response to feed intake and its DNA methylation profiles
Authors: Devailly Guillaume , Fève Katia , Saci Safia , Sarry Julien , Valière Sophie , Lluch Jérôme , Bouchez Olivier , Ravon Laure , Billon Yvon , Gilbert Hélène , Riquet Juliette , Beaumont Martin , Demars Julie
Published: March 2024

The duodenum is a key organ for the hunger/satiety loop and nutrient sensing. We investigated how the duodenum transcriptome and DNA methylation profiles are affected by feed intakes in pigs. We observed thousands of changes in gene expression levels between overnight-fasted and fed pigs in high-feed efficiency pig lines, but almost none in the related low-feed efficiency pig line.
The Tunnelled Atrial Catheter: A Promising Solution for Vascular Capital Depletion in Dialysis despite Associated Thrombi
Authors: Hajji Meriam , Saied Salah , Mami Ikram , Khadhar Yassine , Ben Ayed Tasnim , Gorsane Imen , Ben Hamida Fethi , Ziadi Jalel , Zouaghi Mohamed Karim , Abderrahim Ezzeddine
Published: March 2024

Introduction. Longer survival in dialysis led to a higher incidence of vascular access complications and failure. With the limited access to kidney transplantation programs and peritoneal dialysis, exhaustion of vascular access for hemodialysis is an increasingly common situation. Among the available options, atrial tunneled dialysis catheter (ATDC) has been reported as an effective vascular access in this population. Methodology. We report the experiences of two nephrology centers in Tunis with ATDC as an ultimate vascular access for dialysis. Case Reports. Two patients with exhausted vasculature underwent ATDC insertion in 2020 and 2022, respectively, as a vascular access of last resort. Both patients underwent CRBI, which resolved with favorable outcomes. One case was complicated by post-operative thrombosis and was successfully treated with thrombolysis. Both patients are currently on dialysis via their ATDC with a catheter patency of 29 months. Conclusion. ATDC is a life-saving and safe vascular access in cases of depleted vasculature. Little more than 50 cases have been reported in the literature during the last 30 years. As the frequency of vasculature exhaustion is expected to increase, preservation of veinous access in patients at risk of chronic kidney disease have never been more crucial.
Supplementary Figures from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors: Hwang Grace H. , Pazyra-Murphy Maria F. , Seo Hyuk-Soo , Dhe-Paganon Sirano , Stopka Sylwia A. , DiPiazza Marina , Sutter Nizhoni , Gero Thomas W. , Volkert Alison , Ombelets Lincoln , Dittemore Georgia , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Agar Nathalie Y.R. , Scott David A. , Segal Rosalind A.
Published: March 2024

Supplemental Figures 1-8
Supplemental Table 4 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors: Hwang Grace H. , Pazyra-Murphy Maria F. , Seo Hyuk-Soo , Dhe-Paganon Sirano , Stopka Sylwia A. , DiPiazza Marina , Sutter Nizhoni , Gero Thomas W. , Volkert Alison , Ombelets Lincoln , Dittemore Georgia , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Agar Nathalie Y.R. , Scott David A. , Segal Rosalind A.
Published: March 2024

Supplemental Table 4
Table S2 from Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy
Authors: Lee Te-An , Tsai En-Yun , Liu Shou-Hou , Hsu Hung Shih-Duo , Chang Shing-Jyh , Chao Chi-Hong , Lai Yun-Ju , Yamaguchi Hirohito , Li Chia-Wei
Published: March 2024

Ongoing clinical trial of phosphorylation-associated small molecule drugs and anti-PD-1/PD-L1 combination
Table S1 from Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy
Authors: Lee Te-An , Tsai En-Yun , Liu Shou-Hou , Hsu Hung Shih-Duo , Chang Shing-Jyh , Chao Chi-Hong , Lai Yun-Ju , Yamaguchi Hirohito , Li Chia-Wei
Published: March 2024

Ongoing clinical trial of SHP-2 specific small molecule drugs on multiple cancers
Supplemental Table 2 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors: Hwang Grace H. , Pazyra-Murphy Maria F. , Seo Hyuk-Soo , Dhe-Paganon Sirano , Stopka Sylwia A. , DiPiazza Marina , Sutter Nizhoni , Gero Thomas W. , Volkert Alison , Ombelets Lincoln , Dittemore Georgia , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Agar Nathalie Y.R. , Scott David A. , Segal Rosalind A.
Published: March 2024

Supplemental Table 2
Figure S6 from FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Figure S6
Figure S3 from FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Figure S3
Figure S4 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Authors: Martins Filipe , Rosspopoff Olga , Carlevaro-Fita Joana , Forey Romain , Offner Sandra , Planet Evarist , Pulver Cyril , Pak HuiSong , Huber Florian , Michaux Justine , Bassani-Sternberg Michal , Turelli Priscilla , Trono Didier
Published: March 2024

Related to Figure 4: ZNF587/417 depletion alters the heterochromatin landscape of lymphoma cells.
Supplementary Movie S1 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Movie S1
Supplementary Fig. S7 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Supplementary Fig. S7
Supplementary Fig. S4 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Supplementary Fig. S4
Supplementary Fig. S2 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Supplementary Fig. S2
Figure S9 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S9
Figure S8 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S8
Figure S4 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S4
Figure S16 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S16
Figure S14 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S14
Figure S12 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S12
Figure S1 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S1
Data from Targeting Ferroptosis-Elicited Inflammation Suppresses Hepatocellular Carcinoma Metastasis and Enhances Sorafenib Efficacy
Authors: Mu Ming , Huang Chun-Xiang , Qu Chuang , Li Pei-Lin , Wu Xiang-Ning , Yao Wudexin , Shen Chu , Huang Rucheng , Wan Chao-Chao , Jian Zhi-Wei , Zheng Limin , Wu Rui-Qi , Lao Xiang-Ming , Kuang Dong-Ming
Published: March 2024

Abstract
Triggering ferroptosis, an iron-dependent form of cell death, has recently emerged as an approach for treating cancer. A better understanding of the role and regulation of ferroptosis is needed to realize the potential of this therapeutic strategy. Here, we observed extensive activation of ferroptosis in hepatoma cells and human hepatocellular carcinoma (HCC) cases. Patients with low to moderate activation of ferroptosis in tumors had the highest risk of recurrence compared to patients with no or high ferroptosis. Upon encountering ferroptotic liver cancer cells, aggregated macrophages efficiently secreted proinflammatory IL1β to trigger neutrophil-mediated sinusoidal vascular remodeling, thereby creating favorable conditions for aggressive tumor growth and lung metastasis. Mechanistically, hyaluronan fragments released by cancer cells acted via an NF-κB–dependent pathway to upregulate IL1β precursors and the NLRP3 inflammasome in macrophages, and oxidized phospholipids secreted by ferroptotic cells activated the NLRP3 inflammasome to release functional IL1β. Depleting either macrophages or neutrophils or neutralizing IL1β in vivo effectively abrogated ferroptosis-mediated liver cancer growth and lung metastasis. More importantly, the ferroptosis-elicited inflammatory cellular network served as a negative feedback mechanism that led to therapeutic resistance to sorafenib in HCC. Targeting the ferroptosis-induced inflammatory axis significantly improved the therapeutic efficacy of sorafenib in vivo. Together, this study identified a role for ferroptosis in promoting HCC by triggering a macrophage/IL1β/neutrophil/vasculature axis.
Significance:
Ferroptosis induces a favorable tumor microenvironment and supports liver cancer progression by stimulating an inflammatory cellular network that can be targeted to suppress metastasis and improve the efficacy of sorafenib.
Data from FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Abstract
Immune checkpoint inhibitors (ICI) transformed the treatment landscape of hepatocellular carcinoma (HCC). Unfortunately, patients with attenuated MHC-I expression remain refractory to ICIs, and druggable targets for upregulating MHC-I are limited. Here, we found that genetic or pharmacologic inhibition of fatty acid synthase (FASN) increased MHC-I levels in HCC cells, promoting antigen presentation and stimulating antigen-specific CD8+ T-cell cytotoxicity. Mechanistically, FASN inhibition reduced palmitoylation of MHC-I that led to its lysosomal degradation. The palmitoyltransferase DHHC3 directly bound MHC-I and negatively regulated MHC-I protein levels. In an orthotopic HCC mouse model, Fasn deficiency enhanced MHC-I levels and promoted cancer cell killing by tumor-infiltrating CD8+ T cells. Moreover, the combination of two different FASN inhibitors, orlistat and TVB-2640, with anti–PD-L1 antibody robustly suppressed tumor growth in vivo. Multiplex IHC of human HCC samples and bioinformatic analysis of The Cancer Genome Atlas data further illustrated that lower expression of FASN was correlated with a higher percentage of cytotoxic CD8+ T cells. The identification of FASN as a negative regulator of MHC-I provides the rationale for combining FASN inhibitors and immunotherapy for treating HCC.
Significance:
Inhibition of FASN increases MHC-I protein levels by suppressing its palmitoylation and lysosomal degradation, which stimulates immune activity against hepatocellular carcinoma and enhances the efficacy of immune checkpoint inhibition.
Data from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Authors: Martins Filipe , Rosspopoff Olga , Carlevaro-Fita Joana , Forey Romain , Offner Sandra , Planet Evarist , Pulver Cyril , Pak HuiSong , Huber Florian , Michaux Justine , Bassani-Sternberg Michal , Turelli Priscilla , Trono Didier
Published: March 2024

Abstract
Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc finger proteins (KZFP) contribute to heterochromatin maintenance at transposable elements (TE). Here, we identified an association of upregulation of a cluster of primate-specific KZFPs with poor prognosis, increased copy-number alterations, and changes in the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL). Depleting two of these KZFPs targeting evolutionarily recent TEs, ZNF587 and ZNF417, impaired the proliferation of cells derived from DLBCL and several other tumor types. ZNF587 and ZNF417 depletion led to heterochromatin redistribution, replicative stress, and cGAS–STING-mediated induction of an interferon/inflammatory response, which enhanced susceptibility to macrophage-mediated phagocytosis and increased surface expression of HLA-I, together with presentation of a neoimmunopeptidome. Thus, cancer cells can exploit KZFPs to dampen TE-originating surveillance mechanisms, which likely facilitates clonal expansion, diversification, and immune evasion.
Significance:
Upregulation of a cluster of primate-specific KRAB zinc finger proteins in cancer cells prevents replicative stress and inflammation by regulating heterochromatin maintenance, which could facilitate the development of improved biomarkers and treatments.
Data from Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis
Authors: Sasine Joshua P. , Kozlova Natalia Y. , Valicente Lisa , Dukov Jennifer , Tran Dana H. , Himburg Heather A. , Kumar Sanjeev , Khorsandi Sarah , Chan Aldi , Grohe Samantha , Li Michelle , Kan Jenny , Sehl Mary E. , Schiller Gary J. , Reinhardt Bryanna , Singh Brijesh Kumar , Ho Ritchie , Yue Peibin , Pasquale Elena B. , Chute John P.
Published: March 2024

Abstract
Bone marrow vascular endothelial cells (BM EC) regulate multiple myeloma pathogenesis. Identification of the mechanisms underlying this interaction could lead to the development of improved strategies for treating multiple myeloma. Here, we performed a transcriptomic analysis of human ECs with high capacity to promote multiple myeloma growth, revealing overexpression of the receptor tyrosine kinases, EPHB1 and EPHB4, in multiple myeloma–supportive ECs. Expression of ephrin B2 (EFNB2), the binding partner for EPHB1 and EPHB4, was significantly increased in multiple myeloma cells. Silencing EPHB1 or EPHB4 in ECs suppressed multiple myeloma growth in coculture. Similarly, loss of EFNB2 in multiple myeloma cells blocked multiple myeloma proliferation and survival in vitro, abrogated multiple myeloma engraftment in immune-deficient mice, and increased multiple myeloma sensitivity to chemotherapy. Administration of an EFNB2-targeted single-chain variable fragment also suppressed multiple myeloma growth in vivo. In contrast, overexpression of EFNB2 in multiple myeloma cells increased STAT5 activation, increased multiple myeloma cell survival and proliferation, and decreased multiple myeloma sensitivity to chemotherapy. Conversely, expression of mutant EFNB2 lacking reverse signaling capacity in multiple myeloma cells increased multiple myeloma cell death and sensitivity to chemotherapy and abolished multiple myeloma growth in vivo. Complementary analysis of multiple myeloma patient data revealed that increased EFNB2 expression is associated with adverse-risk disease and decreased survival. This study suggests that EFNB2 reverse signaling controls multiple myeloma pathogenesis and can be therapeutically targeted to improve multiple myeloma outcomes.
Significance:
Ephrin B2 reverse signaling mediated by endothelial cells directly regulates multiple myeloma progression and treatment resistance, which can be overcome through targeted inhibition of ephrin B2 to abolish myeloma.
NCI Cancer Research Data Commons: Core Standards and Services
Authors: Brady Arthur , Charbonneau Amanda , Grossman Robert L. , Creasy Heather H. , Renner Robinette , Pihl Todd , Otridge John , Kim Erika ,   the CRDC Program, Barnholtz-Sloan Jill S. , Kerlavage Anthony R.
Published: March 2024

The NCI Cancer Research Data Commons (CRDC) is a collection of data commons, analysis platforms, and tools that make existing cancer data more findable and accessible by the cancer research community. In practice, the two biggest hurdles to finding and using data for discovery are the wide variety of models and ontologies used to describe data, and the dispersed storage of that data. Here, we outline core CRDC services to aggregate descriptive information from multiple studies for findability via a single interface and to provide a single access method that spans multiple data commons.

See related articles by Wang et al., p. 1388, Pot et al., p. 1396, and Kim et al., p. 1404
Supplementary Table S4 from Monitoring Minimal Residual Disease in Patients with Multiple Myeloma by Targeted Tracking Serum M-Protein Using Mass Spectrometry (EasyM)
Authors: Fan Huishou , Wang Bing , Shi Lihui , Pan Ni , Yan Wenqiang , Xu Jingyu , Gong Lixin , Li Lingna , Liu Yuntong , Du Chenxing , Cui Jian , Zhu Guoqing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Hao Mu , Zou Dehui , Chen Xiequn , Qiu Lugui , An Gang
Published: March 2024

The dynamic curve of M-protein residual (EasyM) for the 56 patients across the disease course and their corresponding clinical response.
Supplementary Table S3 from Monitoring Minimal Residual Disease in Patients with Multiple Myeloma by Targeted Tracking Serum M-Protein Using Mass Spectrometry (EasyM)
Authors: Fan Huishou , Wang Bing , Shi Lihui , Pan Ni , Yan Wenqiang , Xu Jingyu , Gong Lixin , Li Lingna , Liu Yuntong , Du Chenxing , Cui Jian , Zhu Guoqing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Hao Mu , Zou Dehui , Chen Xiequn , Qiu Lugui , An Gang
Published: March 2024

Baseline characteristics of the patient cohort
Supplementary Figure S1 from Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Progressing on Enzalutamide
Authors: Abida Wassim , Hahn Andrew W. , Shore Neal , Agarwal Neeraj , Sieber Paul , Smith Matthew R. , Dorff Tanya , Monk Paul , Rettig Matthew , Patel Rupal , Page Anne , Duff Maureen , Xu Rongda , Wang Jian , Barkund Shravani , Pankov Aleksandr , Wang Amber , Junttila Melissa R. , Multani Pratik S. , Daemen Anneleen , Chow Maneval Edna , Logothetis Christopher J. , Morris Michael J.
Published: March 2024

Supplementary Figure 1. Nonclinical Mechanisms of Potential Ineffective Dual AR/GR Inhibition
Supplementary Table S1 from Monitoring Minimal Residual Disease in Patients with Multiple Myeloma by Targeted Tracking Serum M-Protein Using Mass Spectrometry (EasyM)
Authors: Fan Huishou , Wang Bing , Shi Lihui , Pan Ni , Yan Wenqiang , Xu Jingyu , Gong Lixin , Li Lingna , Liu Yuntong , Du Chenxing , Cui Jian , Zhu Guoqing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Hao Mu , Zou Dehui , Chen Xiequn , Qiu Lugui , An Gang
Published: March 2024

Representativeness of Study Participants
Supplementary Figure S1 from Monitoring Minimal Residual Disease in Patients with Multiple Myeloma by Targeted Tracking Serum M-Protein Using Mass Spectrometry (EasyM)
Authors: Fan Huishou , Wang Bing , Shi Lihui , Pan Ni , Yan Wenqiang , Xu Jingyu , Gong Lixin , Li Lingna , Liu Yuntong , Du Chenxing , Cui Jian , Zhu Guoqing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Hao Mu , Zou Dehui , Chen Xiequn , Qiu Lugui , An Gang
Published: March 2024

Survival outcomes of the entire patient cohort
Supplementary Table S4 from The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
Authors: Halabi Susan , Guo Siyuan , Park Joseph J. , Nanus David M. , George Daniel J. , Antonarakis Emmanuel S. , Danila Daniel Costin , Szmulewitz Russell Zelig , McDonnell Donald P. , Norris John D. , Lu Changxue , Luo Jun , Armstrong Andrew J.
Published: March 2024

Hazard Ratio of PFS by baseline HOXB13 status, (CellSearch) CTC, and JHU AR-V7
Supplementary Table S3 from The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
Authors: Halabi Susan , Guo Siyuan , Park Joseph J. , Nanus David M. , George Daniel J. , Antonarakis Emmanuel S. , Danila Daniel Costin , Szmulewitz Russell Zelig , McDonnell Donald P. , Norris John D. , Lu Changxue , Luo Jun , Armstrong Andrew J.
Published: March 2024

Hazard Ratio of OS by baseline HOXB13 status, (CellSearch) CTC, and EPIC AR-V7 CTC status
Supplementary Figure S1 from The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
Authors: Halabi Susan , Guo Siyuan , Park Joseph J. , Nanus David M. , George Daniel J. , Antonarakis Emmanuel S. , Danila Daniel Costin , Szmulewitz Russell Zelig , McDonnell Donald P. , Norris John D. , Lu Changxue , Luo Jun , Armstrong Andrew J.
Published: March 2024

CONSORT Diagram
Supplementary Table S2 from Early Detection of Molecular Residual Disease and Risk Stratification for Children with Acute Myeloid Leukemia via Circulating Tumor DNA
Authors: Liu Li-Peng , Zong Su-Yu , Zhang Ao-Li , Ren Yuan-Yuan , Qi Ben-Quan , Chang Li-Xian , Yang Wen-Yu , Chen Xiao-Juan , Chen Yu-Mei , Zhang Li , Zou Yao , Guo Ye , Zhang Ying-Chi , Ruan Min , Zhu Xiao-Fan
Published: March 2024

Table S2. Representativeness of Study Participants
Supplementary Table S7 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Top TSGs upregulated in response to NTX-301.
Supplementary Figure S5 from Early Detection of Molecular Residual Disease and Risk Stratification for Children with Acute Myeloid Leukemia via Circulating Tumor DNA
Authors: Liu Li-Peng , Zong Su-Yu , Zhang Ao-Li , Ren Yuan-Yuan , Qi Ben-Quan , Chang Li-Xian , Yang Wen-Yu , Chen Xiao-Juan , Chen Yu-Mei , Zhang Li , Zou Yao , Guo Ye , Zhang Ying-Chi , Ruan Min , Zhu Xiao-Fan
Published: March 2024

Figure S5. Comparison of PFS stratified by the different timepoint post-treatment residual status either of plasma ctDNA or MFC at (A) C2D1, (B) C3D1 and (C) C4D1 post-treatment. ctDNA neg-MFC neg was defined as the VAF of mutation being negative for ctDNA and MRD being negative for MFC at each timepoint. ctDNA pos-MFC neg was defined as the VAF of mutation >0.01% for ctDNA and MRD being negative for MFC at each timepoint. ctDNA pos-MFC pos was defined as the VAF of mutation >0.01% for ctDNA and immunophenotype ≥10−4 myeloblasts for MFC at each timepoint. MFC, multiparameter flow cytometry; C2D1, Cycle 2 day 1; C3D1, Cycle 3 day 1; C4D1, Cycle 4 day 1
Supplementary Table S6 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Top 30 upregulated DEGs in OVCAR5 cells treated with NTX301 compared to DMSO. TSGs are bolded.
Supplementary Figure S3 from Early Detection of Molecular Residual Disease and Risk Stratification for Children with Acute Myeloid Leukemia via Circulating Tumor DNA
Authors: Liu Li-Peng , Zong Su-Yu , Zhang Ao-Li , Ren Yuan-Yuan , Qi Ben-Quan , Chang Li-Xian , Yang Wen-Yu , Chen Xiao-Juan , Chen Yu-Mei , Zhang Li , Zou Yao , Guo Ye , Zhang Ying-Chi , Ruan Min , Zhu Xiao-Fan
Published: March 2024

Figure S3. Kaplan-Meier plot showed the PFS of patients diagnosed as CBF and non-CBF AML underwent dynamic monitoring of mutations by ctDNA from admission to the last cycle of chemotherapy. PFS, progression-free survival. CBF, core binding factor
Supplementary Figure S2 from Early Detection of Molecular Residual Disease and Risk Stratification for Children with Acute Myeloid Leukemia via Circulating Tumor DNA
Authors: Liu Li-Peng , Zong Su-Yu , Zhang Ao-Li , Ren Yuan-Yuan , Qi Ben-Quan , Chang Li-Xian , Yang Wen-Yu , Chen Xiao-Juan , Chen Yu-Mei , Zhang Li , Zou Yao , Guo Ye , Zhang Ying-Chi , Ruan Min , Zhu Xiao-Fan
Published: March 2024

Figure S2. Comparison of CIR stratified by the different timepoint post treatment residual status either of plasma ctDNA (A-C) or mutation in BM (D-F). CIR according to residual status either of plasma ctDNA (A) or mutation in BM (D) at C2D1 post treatment; CIR according to residual status either of plasma ctDNA (B) or mutation in BM (E) at C3D1 post treatment; CIR according to residual status either of plasma ctDNA (C) or mutation in BM (F) at C4D1 post treatment. A higher CIR was associated with patients with ctDNA or BM DNA positive results at any point (all p<0.001). BM, bone marrow; CIR, cumulative incidence of relapse; C2D1, Cycle 2 day 1; C3D1, Cycle 3 day 1; C4D1, Cycle 4 day 1
Supplementary Table S3 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Primer sequences for H3K27Ac ChIP-qPCR
Supplementary Table S1 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Tumor characteristics
Figure S3 from An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer
Authors: Lukovic Jelena , Pintilie Melania , Han Kathy , Fyles Anthony W. , Bruce Jeffrey P. , Quevedo Rene , Pugh Trevor J. , Fjeldbo Christina S. , Lyng Heidi , Milosevic Michael F.
Published: March 2024

Figure S3
Supplementary Figure S4 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Effects of HMAs on HDAC expression.
Figure S1 from An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer
Authors: Lukovic Jelena , Pintilie Melania , Han Kathy , Fyles Anthony W. , Bruce Jeffrey P. , Quevedo Rene , Pugh Trevor J. , Fjeldbo Christina S. , Lyng Heidi , Milosevic Michael F.
Published: March 2024

Figure S1
Table S3 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Table S3. qRT-PCR primers used.
Figure S9 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S9. miR-200c-3p promotes the M2 polarization of microglia in vivo.
Supplementary Data 1 from Transverse Colon Primary Tumor Location as a Biomarker in Metastatic Colorectal Cancer: A Pooled Analysis of CCTG/AGITG CO.17 and CO.20 Randomized Clinical Trials
Authors: Solar Vasconcelos Joao Paulo , Chen Nan , Titmuss Emma , Tu Dongsheng , Brule Stephanie Y. , Goodwin Rachel , Jonker Derek J. , Price Timothy , Zalcberg John R. , Moore Malcolm J. , Karapetis Christos S. , Siu Lillian , Shapiro Jeremy , Simes John , Gill Sharlene , O'Callaghan Chris J. , Loree Jonathan M.
Published: March 2024

Supplementary data
Figure S6 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S6. A-NDEs promote mouse microglial M2 polarization.
Figure S2 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S2. Characterization of neuron-derived exosomes.