bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Individuals’ Opinion and Non-opinion Characteristics on the Organization of Influence Networks in the Online Domain
Authors: Gezha Vladislav N. , Kozitsin Ivan V.
Published: May 2023

The opinion dynamics literature argues that the way people perceive social influence depends not only on the opinions of interacting individuals, but also on the individuals’ non-opinion characteristics, such as age, education, gender, or place of residence. The current paper advances this line of research by studying longitudinal data that describe the opinion dynamics of a large sample (~30,000) of online social network users, all citizens of one city. Using these data, we systematically investigate the effects of users’ demographic (age, gender) and structural (degree centrality, the number of common friends) properties on opinion formation processes. We revealed that females are less easily influenced than males. Next, we found that individuals that are characterized by similar ages have more chances to reach a consensus. Besides, we report that individuals who have many common peers find an agreement more often. We also demonstrated that the impacts of these effects are virtually the same, and despite being statistically significant, are far less strong than that of opinion-related features: knowing the current opinion of an individual and, what is even more important, the distance in opinions between this individual and the person that attempts to influence the individual is much more valuable. Next, after conducting a series of simulations with an agent-based model, we revealed that accounting for non-opinion characteristics may lead to not very sound but statistically significant changes in the macroscopic predictions of the populations of opinion camps, primarily among the agents with radical opinions (≈ 3% of all votes). In turn, predictions for the populations of neutral individuals are virtually the same. Besides, we demonstrated that the accumulative effect of non-opinion features on opinion dynamics is seriously moderated by whether the underlying social network correlates with the agents’ characteristics. After applying the procedure of random shuffling (in which the agents and their characteristics were randomly scattered over the network), the macroscopic predictions have changed by ≈ 9% of all votes. What is interesting, the population of neutral agents was again not affected by this intervention.
Total Vertex Irregularity Strength Of Prismatic Graph Amalgamation
Authors: Sesa Junianto , Muhlis La Ode
Published: May 2023

It is not possible to determine the total vertex of irregular strength of all graphs. This study aims to ascertain the total vertex irregularity strength in prismatic graph amalgamation for n>=4. Determination of the total vertex irregularity strength in prismatic graph amalgamation is done by ascertaining the largest lower limit and the smallest upper limit. The lower limit is analyzed based on the graph properties and other supporting theorems, while the upper limit is analyzed by labeling the vertices and edges of the prismatic amalgamation graph. Based on the results of this study, the total vertex irregularity strength in prismatic graph amalgamation is obtained, namely (4(P2,n))=2n , for n>=4.
Continuous weaving $g$-frames in Hilbert $C^{\ast}$-modules
Authors: Ghiati M'hamed , Mouniane Mohammed , Assila Nadia , Rossafi Mohamed
Published: May 2023

The present paper aims to study $c$-$g$-woven for Hilbert $C^ {*} $-module spaces, first, we give some definitions and fundamental properties which will be useful to introduce the notion. And also some of his properties are given. Finally, we discuss the perturbation for $c$-$g$-woven.
Persepsi Dosen IAIN Samarinda Tentang Pemakaian Cadar di Lingkungan Kampus
Authors: Safendi Abdi , Haries Akhmad
Published: May 2023

Melihat dari fenomena mahasisiwi IAIN Samarinda akhir-akhir ini banyak yang mengenakan cadar. Hal ini kemudian menimbulkan persepsi bagi dosen-dosen, ada yang berpersepsi positif dan ada pula yang berpersepsi negatif. Jenis penelitian yang digunakan adalah penelitian lapangan (field research) dengan metode deskriptif kualitatif yang diperoleh dari hasil wawancara dengan 18 dosen tetap PNS maupun Non-PNS IAIN Samarinda. Persepsi dosen tentang mahasiswi yang memakai cadar ada yang positif dalam artian dengan tanggapan yang baik, hal ini karena mereka beranggapan bahwa mahasiswi yang memakai cadar tersebut dapat menjauhkan dirinya dari hal yang bersifat negatif serta untuk menjaga diri dan kecantikannya. Tapi hampir seluruh dosen mengharapkan mahasiswi di kampus yang memakai cadar hendaknya ketika berada pada jam atau dalam perkuliahan untuk membuka cadarnya agar perkuliahan bisa lebih efektif. Namun ada pula yang memberikan persepsi negatif dalam artian dengan tanggapan yang kurang baik, hal tersebut karena mahasiswi yang bercadar itu kurang sopan dan berlebihan dalam kondisi tertentu misalnya di kampus saat jam perkuliahan karena terkadang ada yang pasif dan ekslusif dalam berinteraksi. Selain itu terdapat beberapa faktor yang mempengaruhi persepsi dosen IAIN Samarinda yaitu, diri orang yang bersangkutan, sasaran dari persepsi itu sendiri, dan faktor situasi. Misalnya saja ada sebagian dosen yang beranggapan agak sulit membedakan atau mengetahui mahasiswi yang sama-sama pakai cadar, apakah dia itu orang yang dimaksud atau bukan.

 

Kata kunci: Cadar, pakaian syar’i, IAIN Samarinda
PRAKTIK PERNIKAHAN ADAT JAWA KEMBAR MAYANG DAN PECAH TELOR (Studi Kasus Desa Kayulompa Kecamatan Basidondo)
Authors: Faishol Imam
Published: May 2023

Penelitian ini dilatarbelakangi dengan adanya temuan di desa Kayulompa Kecamatan Basidondo yaitu adanya praktik pernikahan yang memakai adat kembar mayang dan pecah telor. Tujuan menggunakan adat kembar  mayang dan pecah telor tersebut sebagai bentuk ketaatan suami terhadap istri. Praktik adat Jawa kembar mayang dan pecah telor ialah salah satu adat istiadat jawa yang mana setiap pengantin harus melaksanakannya, agar menghindari hal-hal yang tidak terduga seperti merusak harga diri. Termasuk dalam melaksanakan praktik pernikahan adat Jawa, keyakinan yang diturunankan dari nenek moyang tanpa mereka sadari telah menjadi suatu keyakinan, yang mana mereka juga mewarisi dan mempertahankan adat mereka. Peneliti mengkategorikan kembar mayang dan pecah telor termasuk ‘urf  fasidah karena para ulama sepakat, bahwa ‘urf fasidah tidak menjadi landasan hukum, dan kebiasaan tersebut batal demi hukum. Praktik kembar mayang juga adalah adat Jawa yang di dalamnya termasuk ‘urf fasidah (tidak benar), yaitu suatu adat kebiasaan yang sampai menghalalkan yang diharamkan Allah kebalikan dari ‘urf shahihah.
Konsep Maqasid Syariah menurut Muhammad Thahir Ibnu 'Asyur
Authors: Idzhar Muhammad
Published: May 2023

Teori Maqasid Syari’ah dalam wacana hukum Islam dan ushul fiqh memiliki sejarah yang sangat berliku-liku. Di setiap fase sejarah teori ini memiliki ciri dan watak yang berbeda-beda ditangan para penggagasnya masing-masing. Hal ini membuktikan bahwa teori maqasid syari’ah ini mengalami semacam evolusi dan selalu berkembang menurut semangat zaman dan kebutuhan sosial yang melingkupinya. Saat ini, era globalisasi yang berbasis pada Negara global (global governance) dan Negara bangsa telah lahir tantangan-tantangan dan masalah yang sangat kompleks. Karenanya dibutuhkan rekonstruksi dan kontekstualisasi terhadap maqasid syari’ah agar dapat menjawab tantangan ruang dan waktu. Muhammad Thahir Ibnu ‘Asyur menawarkan pendekatan baru dalam mempelajari maqasid syari’ah sebagai ilmu independen dalam menetapkan hukum yang disesuaikan dengan konteks kekinian dan modern. Penelitian ini merupakan penelitian pustaka (library research) melalui kajian pustaka yang mendalam. Dari hasil penelitian, dalam penetapan pokok-pokok maqasid syariah, Ibnu ‘Asyur dalam kreasi inovatifnya membagi menjadi tiga kategori, yaitu legalitas hukum Maqasid dan urgensi penerapannya dalam merumuskan hukum, maqasid ‘ammah, dan maqasid khassah. Selain itu konsep maqasid syari’ah yang digagas oleh Ibnu ‘Asyur memiliki relevansi dalam aktualisasi fiqih, sehingga konsep ini relevan dalam menyelesaikan masalah kekinian.
Praktek Takaran Jual Beli Binur Udang Dalam Perspektif Hukum Islam dan Perlindungan Konsumen Di Sungei Meriyam
Authors: Maryah Dewi
Published: May 2023

Penelitina ini menggangkat masalah jual beli binur udang sebagai objek penelitian, khususnya para pelaku usaha penjualan binur udang yang menggunakan alat takaran tidak sesuia alat ukur sebagaimana ketentuan undang – undang, selain itu system akad jual beli yang dilakukan tidak sama dengan kenyataan yang diteriam oleh pembeli (konsumen). Tidak ada pilihan lain yang harus diterima oleh para konsumen karena semua pelaku usaha bibit udang tersebut melakukan hal yang sama. Dengan menggunakan pendekatan sosiologis-yuridis, penelitian ini berusaha menangkap fenomena fakta lapangan dengan menggunakan analisis teroi – teori perlindungan konsumen, jual beli dalam hukum islam, konsep dasar hokum takaran dan timbangan. Temuan dalam penelitian ini juga menunjukkan bahwasanya kesalahan dalam praktek jual beli binur udang ini tidak hanya dari sisi akadnya (hukum Islam  ) akan tetapi alat yang digunakan sebagai tolak ukur (berat volume) yang tidak sesuai kebijakan peraturan. Dalam  kaitanya dengan perdagangan baik secara hokum positif maupun dari sisi bermuamalah perlu adanya tindak lanjut dari penegakan hukum sebagaimana mestinya
KETERLIBATAN PERAN SUAMI DI WILAYAH DOMESTIK DALAM MEWUJUDKAN KEHARMONISAN KELUARGA
Authors: Zakiyya Sulung Najmawati
Published: May 2023

Abstrak:

Penelitian ini bertujuan untuk membedah tentang pembagian pola peran suami istri dan pentingnya pola komunikasi dalam urusan domestik. Fokus kajian guna menjawab bagaimana pola relasi suami istri dalam menjalankan peran dan tanggung jawab sebagai suami ataupun istri serta peneliti juga berusaha mengurai detil tentang pola komunikasi antar suami istri dalam berbagi peran nya dalam kehidupan rumah tangga.

Peran sebagai suami istri atau ayah ibu, merupakan konsekuensi dari kehidupan perkawinan. Di dalam perkawinan, masing-masing individu terikat oleh suatu hak dan kewajiban yang harus dilakukannya dalam kurun waktu yang panjang, dan diharapkan kedua belah pihak saling dapat menyesuaikan diri sejalan dengan tugas kehidupan dalam keluarga. Kuatnya pengaruh budaya patriarkhi menjadikan pembagian peran pada laki-laki lebih otoriter dan menempatkan posisi perempuan menjadi satu-satunya figur yang bertanggung jawab terhadap pekerjaan domestik, pengasuhan anak dan reproduksi. Norma sosial yang menempatkan laki-laki di atas perempuan tidak selalu menguntungkan laki-laki sendiri karena laki-laki dituntut untuk menjadi tulang punggung keluarga yang harus bertanggung jawab seutuhnya terhadap kehidupan anggota keluarga yang lain. Minimnya pemahaman dan keterlibatannya laki-laki tentang pembagian peran dan tanggung jawab dalam pekerjaan domestik, khususnya pada pola asuh anak menjadikan istri sebagai satu-satunya penanggung jawab atas kewajiban tersebut. Kondisi ini menempatkan gambaran seorang istri hanyalah sebagai pelengkap dan bukan partner yang dapat diajak bekerja sama dalam suatu relasi perkawinan.
Teacher Pedagogic Competence in Improving Arabic Language Learning Outcomes Based on Curriculum Integration
Authors: Febriani Suci Ramadhanti , Rahmawati Rahmawati , Amrulloh Muhammad Afif , Bedra Kddour Guettaoui
Published: May 2023

The teacher's pedagogical competence influences the use of strategies and the ability to manage the learning system in the classroom. This encourages teachers' efforts to have pedagogical competence in carrying out learning activities optimally. Integrating the Ministry of Religion and the Diniyyah Arabic Center (DAC) curriculum is the basis for strengthening teachers’ pedagogical competence. On that basis, this study aims to identify the pedagogic competence of teachers based on integrating the Ministry of Religion curriculum and the Diniyyah Arabic Center curriculum (DAC) at Diniyyah Puteri Padang Panjang. This research is based on a descriptive qualitative approach by identifying the implementation of teaching competencies based on integrating the Arabic language curriculum at Diniyyah Puteri Padang Panjang. The results showed that the implementation of the teacher's pedagogic competence in improving Arabic learning outcomes was obtained through: (1) identifying priority learning objectives, (2) implementing a learning system according to the order and needs of the learner, and (3) evaluating the learning system periodically. The findings indicate that the pedagogic competence of teachers can encourage an increase in Arabic language skills based on curriculum integration at Diniyyah Puteri Padang Panjang.
Nilai-Nilai Kepemimpinan Islam dalam Buku Islamic Golden Stories Karya Ahmad Rofi’ Usmani
Authors: Muliyandari Atika , Arafah Nurul
Published: May 2023

In this era of increasingly advanced development, many people forget and abandon the true meaning of leadership. This study aimed to discover Islamic leadership's values in the book Islamic Golden Stories by Ahmad Rofi' Usmani. The type of research used is library research, then uses a qualitative approach with an inductive thinking method. After the analysis phases were carried out, it was found that there was compatibility between the values ​​of Islamic leadership and the book Islamic Golden Stories by Ahmad Rofi' Usmani. These Islamic leadership values ​​include Siddiq, namely daring to admit mistakes and being responsible, amanah, namely being trustworthy; exemplary; be fair; high lead loyalty; and loving the people, tabligh consists of listening to advice and carrying out tasks, and fatonah consists of broad-mindedness; wise; able to control emotions; and have innovation. Then, the values ​​of Islamic leadership have contributed to the leadership of school principals because the values ​​of Islamic leadership in the book Islamic Golden Stories by Ahmad Rofi' Usmani are in conformity with the Regulation of the Minister of Education Number 13 of 2007 concerning school principal leadership which includes personality competence, competence managerial, entrepreneurial competence, supervision competence, and social competence.
The Influential Factors of Parents' Involvement in Early Childhood Education: Study of Children 4-6 Years Old
Authors: Kale Sartika , - Sugito , Dewanti Septinda Rima
Published: May 2023

This research aimed at identifying the influence of socio-economic status towards parents’ involvement, the influence of teacher social competence towards parents’ involvement, the influence of school climate towards parents’ involvement, and the influence of parents’ socio-economic status, teacher social competence, and school climate towards students’ involvement in early childhood education, specifically in kindergartens located in Kupang City, East Nusa Tenggara. This quantitative study was designed using ex post facto reseach method. There were 203 parents of 89 Kindergartens chosen to be the research sample determined by using purposive sampling technique. Questionnaires were used to collect the data which was then analyzed using descriptive analysis and regression. The result of study reveals a significant influence of soci-economic status; no significant influence of teacher social competence towards parents’ involvement; a significant influence of school climate towards parents’ involvement; and a simultaneously significant influence of socio-economic status, teacher social competence, and school climate towards parents’ involvement. Finally, in order to improve parental involvement, education policymakers have to consider socioeconomic status and school climate.
Penerapan Dialog System Pada Game Doa Harian Menggunakan Metode Mechanics Dynamics Aesthetics Framework
Authors: Rozani Muhammad Royyan
Published: May 2023

Abstrak
Doa merupakan suatu permohonan dan pujian dalam bentuk ucapan dari seorang hamba kepada tuhan yang maha esa Allah.swt, dan dari setiap ibadah yang di lakukan pasti mengandung doa di dalamnya. Dengan adanya penerepan teknologi dapat membuat ketertarikan pada pembelajaran saat ini khususnya pada anak usia dini yang memiliki ketertarikan terhadap game digital yang sudah banyak berkembang seperti saat ini. Pada TK Nurul Hidayah, peneliti melakukan wawancara secara online kepada guru yang mengajar disana dan dapat di simpulkan dari wawancara guru sekolah tersebut bahwasanya belum adanya pembelajaran khusus tentang pembelajaran doa harian, dirancangnya aplikasi game doa harian diharapkan dapat menambah pembelajaran yang ada di TK Nurul Hidayah dengan menerapkan metode pembelajaran secara visual melalui game. Dengan menerapkan metode penelitian waterfall dan metode mechanics, dynamics, aesthetics (MDA) framework dalam perancangan game doa harian. Dengan pembelajaran beberapa doa dalam kegiatan sehari-hari didalam rumah. Menerapkan sistem dialog pada game sehingga  pengguna dapat berinteraksi dengan karakter ketika memainkan game. Game ini sebagai media alat bantu dalam pembelajaran dan tidak dapat menggantikan peran guru dan interaksi antar guru dan murid yang sesungguhnya.
Kata kunci: doa harian, game, TK Nurul Hidayah, dialog, MDA Framework.
 
Abstract
[Implementation of System Dialogue in the Daily Prayer Game Using the Mechanics Dynamics Aesthetics Framework Method] Prayer is a request and praise in the form of speech from a servant to God Almighty Allah.swt, and from every worship that is done there must be a prayer in it. With the application of technology, it can create interest in learning today, especially in early childhood who have an interest in digital games that have developed a lot like today. At Nurul Hidayah Kindergarten, researchers conducted online interviews with teachers who teach there and it can be concluded from the school teacher interviews that there is no special learning about daily prayer learning, the design of the daily prayer game application is expected to add to the learning in Nurul Hidayah Kindergarten by apply visual learning methods through games. By applying the waterfall research method and the mechanics, dynamics, and aesthetics (MDA) framework in the design of the daily prayer game. By learning some prayers in daily activities at home. Implement a dialogue system in the game so that users can interact with characters while playing the game. This game is a media tool in learning and cannot replace the role of the teacher and the real interaction between teachers and students.
Keywords: daily prayers, games, Nurul Hidayah Kindergarten, dialogue, MDA Framework.
Critical Thinking: A Prerequisite for a New Economics Paradigm
Authors: Mouatt Simon
Published: May 2023

In this paper I posit that most of the serious existential crises faced by humanity are, directly or indirectly, derived from a flawed, yet surprisingly resilient, economic philosophy. The free-market system has certainly produced some benefits, which may counterbalance some of its detrimental impact, but given the persistence of euphemistic and managed narratives in the mainstream political, academic, and media realms, most critical debate is stifled. The paper suggests that it is imperative for the extant research paradigm to be first fully critiqued, then transformed, and finally adopted by the political classes. If a new paradigm gains sufficient traction, however, it will have succeeded where the neoliberal critics of the last fifty years have failed. This paper hopes to offer people fresh insight into this hitherto insurmountable problem.
Strategi Branding Muktamar Muhammadiyah ke-48 di Media Digital dalam Upaya Mempertahankan Citra dan Eksistensinya
Authors: Pratiwi Dwi , Purworini Dian
Published: May 2023

Muktamar merupakan permusyawaratan terbesar Muhammadiyah yang dilaksanakan setiap lima tahun. Pelaksanaan Muktamar ke-48 ditunda dua tahun karena Covid-19 dan dikhawatirkan hilangnya awareness masyarakat terhadap Muktamar. Oleh karena itu, dibutuhkan strategi branding untuk mempertahankan eksistensi perhelatan akbar ini. Tujuan penelitian ini yaitu menganalisis strategi branding Muktamar Muhammadiyah ke-48 di media digital dalam mempertahankan citra dan eksistensi. Metode penelitian ini kualitatif deskriptif dengan teknik Snowball Sampling dan teori Integrasi Informasi. Hasil penelitian menunjukkan bahwa Muktamar 48 menghadirkan kesan Muhammadiyah organisasi islam modern yang siap menghadapi era digitalisasi, cinta kebersihan, tertib, gembira dan bermanfaat bagi masyarakat. Kesan positif juga dapat ditemui pada brand personality ramah, sopan santun, lembut, mengedukasi, menginspirasi, cerdas, dan bermartabat. Identity brand ditunjukan dalam bentuk logo, lagu, tagline, dan brand guidelines. Untuk menjangkau audiens yang luas maka Panitia Muktamar memaksmalkan peran media mainstream dan digital serta agar pesan tersampaikan dengan baik dilakukan strategi pengorganisasian pesan media official dan memperhatikan kredibilitas informasi dengan memberlakukan sistem layer berjenjang yang berfungsi mengontrol, verifikasi, dan validasi seluruh informasi.
Los nudibranquios del mar peruano: una lista de especies actualizada
Authors:   , Grández Urbina Alessandra
Published: May 2023

Los nudibranquios son, en líneas generales, organismos poco estudiados a lo largo de la costa peruana. El presente trabajo provee una lista actualizada de especies de nudibranquios basado en recopilación bibliográfica. Se logró compilar 31 especies distribuidas en 2 subórdenes, 10 superfamilias, 20 familias y 28 géneros. Según las provincias biogeográficas marino-costeras presentes en el Perú, 23 especies habitan en la provincia biogeográfica del Pacífico Sudeste Templado cálido, 18 en la provincia Pacífico Oriental Tropical y 10 habitan en ambas provincias. En cuanto a patrones de distribución, dos especies exhiben distribución cosmopolita (Glaucus atlanticus y Fiona pinnata), dos exhiben distribución circumtropical (Cephalopyge trematoides y Phylliroe bucephala), una exhibe distribución bipolar en la costa del Pacífico Oriental y anfi-sudamericana (Rostanga pulchra), seis exhiben distribución anfi-sudamericana (Rostanga pulchra, Diaulula punctuolata, Doto uva, Tyrinna evelinae, Tyrinna delicata y Doris fontainii) y dos especies son endémicas de Perú (Corambe mancorensis y Felimare sechurana). Se incluyen y discuten aspectos biogeográficos, distribuciones geográficas, actualizaciones sobre clasificación taxonómica. Además, se presenta una breve discusión sobre las especies enlistadas y persistentes en la literatura, pero no confirmadas por colectas (referidas aquí como predichas).
Cambios en la actividad física y hábitos alimentarios durante el confinamiento por COVID-19 en estudiantes de la Universidad Científica del Sur
Authors:   , Hinostroza Carmona Milly Roxana , Jihuaña Galvez Aracely Laura
Published: May 2023

Fundamentos. A fines del 2019 en la ciudad Wuhan-China se reportó algunos casos de neumonía, pero de una causa desconocida, enfermedad causada por el virus SARS-CoV-2 ocasionando la pandemia mundial de COVID-19. Por lo cual, el gobierno peruano implementó medidas de distanciamiento social para prevenir la propagación del virus. El objetivo del estudio fue determinar los cambios en el nivel de actividad física y hábitos alimentarios antes y después del confinamiento por COVID-19 en estudiantes de la Facultad de Ciencias de la Salud de la Universidad Científica del Sur. Métodos. Se realizó un estudio descriptivo, correlacional, observacional de corte transversal en estudiantes de las carreras Medicina Humana, Enfermería, Farmacia y Bioquímica, Estomatología/Odontología, Nutrición y Dietética, Obstetricia y Psicología de 1er a 6to ciclo académico (n=487). Se utilizaron dos cuestionarios previamente validados en otros estudios, entre los meses de febrero a junio de 2022. Resultados. El 68% de los participantes se encontraba entre los 18 a 21 años, y el 69,2% fueron mujeres. Respecto a la actividad física antes de la pandemia el 43,5% de universitarios tenían un nivel de actividad física alta, 20,9% moderada y 35,5% leve o baja y después de la pandemia presentaron 43,1% de actividad física alta, 24% moderada y 32,9% leve o baja. Los hábitos alimentarios de los estudiantes universitarios antes de la pandemia presentaron 51,1% de hábitos alimentarios inadecuados y 48,9% adecuado y después de la pandemia 51,5% de hábitos alimentarios inadecuados y 48,5% adecuados. Conclusiones. El periodo de confinamiento por la pandemia COVID-19 en Perú, ha provocado cambios positivos induciendo un mayor consumo de alimentos como la avena, verduras y menestras. Asimismo, se encontró cambios en la frecuencia de actividad física intensa y moderada antes y después de la pandemia.
Baicalin ameliorates DSS-induced ulcerative colitis in mice through gut microbiota and TNF pathway
Authors: Hu Jie , Zhu Lijuan , Jin Wenqi , Li Xiaojia , Li Peng , Yang Wei , Guo Xiutian
Published: May 2023

The development of ulcerative colitis (UC) results from many factors such as intestinal microflora regulatory genes and immune environment. Studies in humans and research animals suggest mucosa health is associated with gut microbiota, but the detailed regulation mechanism is currently unknown. Baicalin, as a flavonoid, has been reported to play an anti-inflammatory role in several diseases, but its effect on UC and gut microbiota is still unclear. In this study, we characterized the protective effects of baicalin in a dextran sulfate sodium (DSS)-induced colitis mouse model and investigated the potential molecular mechanism. With a well-known DSS-induced UC model and consistent treatment with baicalin, we found that baicalin plays a critical role in treating DSS-induced colitis. Transcriptome analysis revealed that the IL17 and TNF pathway genes decreased in tissue after baicalin treatment. 16S DNA gene sequencing demonstrated that microbial diversity (observed species/Chao1/Shannon diversity) was increased in the baicalin treatment mice. Principal coordinate analysis using Bray-Curtis dissimilarity and UniFrac revealed microbial shifts in UC mice after baicalin treatment. All in all, our data showed that pretreatment with baicalin reduced intestinal inflammation and apoptosis status which was closely related to the altered gut microbiota to favor the genera Intestinimonas and Bacteroides.
Effect of dietary Spirulina platensis Phycocyanin and Fucoidan supplementation on egg properties, blood parameters, and Bacteriological count of laying Japanese quails
Authors: Tohidifar Seyyed Sattar , Habibi Hassan , Jafari Maryam , Mohammadi Mehdi
Published: May 2023

This study was conducted to evaluate the effects of dietary Spirulina platensis Phycocyanin and fucoidan supplementation on laying performance, egg quality, relative organ weight, and blood profile of laying Japanese quails. Birds (n = 450; 7-week-old) were divided into 5 experimental groups (90 chicks each, 3 replicates/group, 30 chicks/replicate), and fed with 5 experimental diets. The groups contained basal control diet, the control diet supplemented with 0.02 % phycocyanin (Phy 0.02%), 0.04 % phycocyanin (Phy 0.04%), 0.02 % fucoidan (Fuco 0.02%), or 0.04 % fucoidan (Fuco 0.04%).
Results showed that all treatment groups significantly increased egg production at the end of the experiment compared to the control (P < 0.05). fucoidan significantly decreased Cholesterol, triglyceride, and yolk Chol in all concentrations compared to the control group (P < 0.05). Groups that received phycocyanin increased the level of Albumin and decreased malondialdehyde and triglyceride in comparison with the control group (P < 0.05). On day 15 post storage, the groups that received Fuco and Phy had fewer TVN and TBA values in comparison to the control group (P < 0.05). Supplementation with fucoidan and Phy 0.04% decreased the total and coliform count of bacteria from day 0 until day 15 post-storage (P < 0.05).
In conclusion, this study demonstrated that addition of dietary fucoidan and phycocyanin positively affects egg production, levels of total protein, albumin, HDL, and the quality aspects and bacteriological counts of quail’s egg and by increasing the storage time, the safety of the product will be increased.
Resistin-like molecule β (RELMβ) secreted by macrophages promotes epithelial-mesenchymal transition of alveolar epithelial cells in diabetic lungs
Authors: Zhang Yawen , Xiang Meng , Wang Xuanchun , Wang Yi , Gao Xiangyu , Qian Jiali , Huang Chuxin , Miao Qing , Sun Wanwan , Zhang Qiongyue , Yang Jia , Zhang Li , Yang Yehong
Published: May 2023

Aims: To explore the characteristics of diabetic lung injury and the role of resistin-like molecule β (RELMβ).
Methods: The experimental diabetic mice were established by intraperitoneal injection of streptozotocin (STZ), the lung function, tissue structure and protein expression levels of the mice were observed. The role of RELMβ on the epithelial to mesenchymal transition (EMT) in A549 cells exposed to high glucose was explored.
Results: The function and structure of the diabetic lungs were significantly impaired, with extensive collagen fibers and macrophages deposited in the alveolar septum, with declined expression of epithelial marker (E-cadherin) and increased expression of mesenchymal markers (α-SMA and Vimentin) and RELMβ. The expression and secretion of RELMβ in macrophages were stimulated by high glucose, and the EMT level in A549 cells was up-regulated by recombinant human RELMβ or co-culture with macrophages.
Conclusions: Diabetic mice showed declined lung function and increased fibrotic changes in lung tissues. Macrophages exposed to high glucose can promote the EMT progression in A549 cells via secreting RELMβ.
Antifungal susceptibility profiles for fungal isolates from corneas and contact lenses in the United Kingdom
Authors: Tuft Stephen , Stone Neil , Burton Matthew , Johnson Elizabeth , Borman Andrew
Published: May 2023

Objective To report the identification and results of susceptibility testing for fungal isolates from the cornea or contact lens care systems.Materials and methods In this retrospective epidemiological study, we searched the results of fungal cultures from cornea or contact lens systems referred for identification and susceptibility testing to the United Kingdom National Mycology Reference Laboratory between October 2016 and March 2022. For each fungal isolate, we recorded the genus and species of the fungus and the minimum inhibitory concentration (MIC) to six antifungal agents available to treat corneal infection (amphotericin, econazole, itraconazole, natamycin, posaconazole, and voriconazole).Results There were 600 isolates from 585 patients, comprising 374 (62%) from corneal samples and 226 from contact lenses and care systems, of which 414 (69%) isolates were moulds (filamentous fungi) and 186 (31%) were yeasts. The most frequent moulds isolated were Fusarium spp (234 isolates, 39%) and Aspergillus spp (62, 10%). The most frequent yeasts isolated were Candida spp (112, 19%), predominantly Candida parapsilosis (11%) and Candida albicans (6%), with 35 isolates (6%) of Meyerozyma guilliermondii. In vitro susceptibility was greatest for natamycin (347 moulds tested, mode 4 mg/L, range 0.25-64 mg/L; 98 yeasts tested, mode 4 mg/L, range 0.5–32 mg/L), with susceptibility for 94% for moulds and 99% yeasts. The isolates interpreted as highly resistant to natamycin (N, 14) were predominantly Aspergillus flavus complex.Conclusions In vitro susceptibility supports the use of natamycin for the empiric treatment of fungal keratitis in the UK.
Predictive and preventive Factors related to of head lice infestations among teenage girls student: Application of Health Belief Model
Authors: -Siuki Hadi Alizadeh , Jadgal Mohammad Saeed , Fahimeh Attarian
Published: May 2023

Background:
Despite of improving public health, head lice infestations has remained as an important health issue among all society in worldwide. Head lice infestations are common in areas with high population density and associated with low socioeconomic status and health literacy. This study aimed to evaluate the preventive behaviors related to pediculosis based on the Health Belief Model (HBM) in teenage girl students.
Methods & Material:
This cross-sectional survey was performed on 200 teenage girl students that randomly selected from 4 schools in different geographical areas in Torbat Heydaryeh city-Iran. A structured questionnaire was designed to collect the data on socio-demographic characteristics, health belief model constructs and pediculosis-related behaviors. This data was descripted and analyzed by two-sample t-test, Pearson's correlation coefficient and regression analysis using SPSS 22.
Result:
The overall percentage of head lice infestations was 4.1% and 9.5% of participations had experience of head lice infestations in the 3 past months. Itching reported in 30% of infected students (p < 0.001). Head lice infestations strongly predicted with itching on a scalp (OR = 73.2, 95% CI 8.23, 652.2), and the main protective factor for Head lice infestations was adopt of preventive behavior (OR = 0.68, 95% CI 0.47, 0.97), also the preventive behavior (according to HBM model) were explained by Perceived barriers, self-efficiency and predisposing factors (5.7%, 5.6% and 7.8%) respectively.
Conclusion:
It seems that should providing necessary trainings with an emphasis on recognizing symptoms of disease and promoting preventive behavior by reinforcing predisposing factors, perceived barriers and self-efficacy in students.
Factors Influencing the Choice of Majors among Chinese Medical Students: An Analysis of Enrollment and Admission Scores in Major Medical Disciplines
Authors: Zhang Zhiyuan , Gu Jiaojiao , Li Wentao
Published: May 2023

Introduction and objectives: The study examines the factors influencing the major choice of medical students in China, including individual preferences, social needs, role models, personal characteristics, and the impact of COVID-19. The aim is to provide insights for medical educators to help students make informed career decisions.Methods The study collected data from 11 universities with the largest medical student enrollment in China. A total of 14,016 valid questionnaires were analyzed using statistical methods.Results The study found that social needs and personal interests were the most significant factors influencing the choice of major for medical students in China. The majors with the largest number of enrollments are Obstetrics and Gynecology &Reproductive medicine, Oncology and Ophthalmology. However, there was a shortage of medical professionals in certain fields, such as emergency medicine and anesthesiology, due to medical students' preference for specialties that do not require emergency room visits or night shifts. COVID-19 also had a significant impact on the major choice of medical students in China, with students showing a greater inclination to pursue clinical medicine.Conclusions The study concludes that addressing the shortage of medical professionals in certain fields requires concerted efforts from the government, society, and educational institutions. Providing incentives and subsidies to doctors who face high work intensity and low pay, as well as offering relevant courses to stimulate students' interest in particular specialties, are some possible solutions. Furthermore, medical schools should ensure that students have sufficient personal time and space outside of their studies and provide adequate psychological support to help students manage the pressures of their demanding profession.
Synchronous profiling of mRNA N6-methyladenosine modifications and mRNA expression in high-grade serous ovarian cancer
Authors: Yang Li , Liu Jingfang , Jin Yanlu , Xing Jie , Zhang Jiejie , Chen Xin , Yu Aijun
Published: May 2023

Objective To synchronously determine epitranscriptome-wide RNA N6-methyladenosine (m6A) modifications and mRNA expression profile in high grade serous ovarian cancer (HGSOC).Methods The methylated RNA immunoprecipitation sequencing (MeRIP-seq) was used to comprehensively examine the m6A modification and the RNA-sequencing (RNA-seq) was performed to analyze the mRNA expression profile in HGSOC and normal fallopian tube (FT) tissues. Go and KEGG analyses were carried out in the enrichment of those differentially methylated and expressed genes.Results MeRIP-seq data showed 53,794 m6A methylated peaks related to 19,938 genes in the HGSOC group and 51,818 m6A peaks representing 19,681 genes in the FT group. RNA-seq results revealed 2,321 upregulated and 2,486 downregulated genes in HGSOC. Conjoint analysis of MeRIP-seq and RNA-seq data identified differentially expressed genes in which 659 were hypermethylated and 897 were hypomethylated. The expression of the m6A eraser (FTO) was significantly lower, but the m6A readers (IGF2BP2 and IGF2BP3) were higher in HGSOC, which was validated by the subsequent real-time PCR assay. Functional enrichment analysis indicated that these differentially modulated genes are involved in pathways related to cancer development.Conclusions For the first time, our study screens the epitranscriptome-wide m6A modification and expression profiles of their modulated genes and signaling pathways in HGSOC. Our findings provide an alternative direction in exploring the molecular mechanisms of ovarian pathogenesis.
Unraveling the Nrf2-ARE Signaling Pathway in DF-1 Cells: Insights into T-2 Toxin-Induced Oxidative Stress Regulation
Authors: yang lingchen , Gao Suisui , Xiao Shuai , Xiong Kuankuan , Liu Zhiwei , Wu Chujian , Li Linfeng , Zhou Mingxia , Yuan Guoxiang , Jiang Lihuang , Xiong Qianbo
Published: May 2023

T-2 toxin (T2) poses a major threat to the health and productivity of animals and livestock. The induction of oxidative stress by T2 has been identified as a central factor in cellular damage. The Nrf2-ARE signaling pathway represents a crucial regulatory mechanism that protects cells from oxidative stress, with nuclear factor E2 related factor 2 (Nrf2) serving as a vital component in this defense. To date, there has been a lack of research on the role of Nrf2 in mediating the effects of T2-induced oxidative stress in broilers. The present study aimed to investigate the regulatory mechanism of Nrf2 protein derived from broilers against T2-induced oxidative damage by constructing Nrf2 overexpression and knockdown DF-1 cell lines. Normal DF-1 cells, Nrf2 overexpressing cells, and Nrf2 knockdown cells were subjected to treatment with 50nM T2 for 24 hours. Results showed that an increase in Nrf2 protein levels was associated with a decrease in oxidative stress in DF-1 cells (P < 0.05) and an upregulation of antioxidant factor mRNA and protein expression. Conversely, downregulation of Nrf2 protein resulted in the opposite outcomes. This study provides valuable insights into the potential treatment of oxidative stress-related diseases in livestock and poultry.
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants
Authors: Damme Daniël Van , Dragwidge Jonathan , Wang Yanning , Brocard Lysiane , De Meyer Andreas , Hudeček Roman , eeckhout Dominique , Grones Peter , Buridan Matthieu , Chambaud Clément , Pejchar Přemysl , Potocký Martin , Winkler Joanna , Vandorpe Michael , Serre Nelson , Fendrych Matyas , Bernard Amélie , De Jaeger Geert , Pleskot Roman , Fang Xiaofeng
Published: May 2023

Clathrin-mediated endocytosis is an essential cellular internalisation pathway involving the dynamic assembly of clathrin and accessory proteins to form membrane-bound vesicles. The evolutionarily ancient TSET/TPLATE complex (TPC) plays an essential, but not well-defined role in endocytosis in plants. Here, we show that two highly disordered TPC subunits, AtEH1 and AtEH2 function as scaffolds to drive biomolecular condensation of the complex. These condensates specifically nucleate on the plasma membrane through interactions with anionic phospholipids, and facilitate the dynamic recruitment and assembly of clathrin, early-, and late-stage endocytic accessory proteins. Importantly, clathrin forms ordered assemblies within the condensate environment. Biomolecular condensation therefore acts to promote dynamic protein assemblies throughout clathrin-mediated endocytosis. Furthermore, the disordered region sequence properties of AtEH1 regulate the material properties of the endocytic condensates in vivo. Alteration of the material properties influences endocytosis dynamics, and thereby impairs environmental adaption. In conclusion, our findings reveal how collective interactions shape endocytosis.
Predictors of Neonatal Mortality in Ethiopia: Cross-Sectional Study Using 2005, 2010, and 2016 Ethiopian Demographic Health Survey Datasets.
Authors: Baruda Yirgalem Shibiru , Spigt Mark , Gabrio Andrea , Assebe Lelisa Fikadu
Published: May 2023

Background Ethiopia has the highest neonatal mortality rate in the world. Although the country has taken measures to reduce neonatal mortality, it has not been able to achieve a significant change in neonatal mortality in the last two decades. The study aims to determine the trends and predictors of change in neonatal mortality in Ethiopia for the past 15 years.Methods The study used Ethiopian Demographic Health Survey Datasets (EDHS) from 2005, 2011, and 2016. All live births of reproductive-age women in Ethiopia were included in the study. Multivariate decomposition analysis for the nonlinear response variable (MVDCMP) based on the logit link function was employed to determine the relative contribution of each independent variable to the change in neonatal mortality over the last 15 years.Result The neonatal mortality rate has decreased by 11 per 1,000 live births, with an annual reduction rate of 2.8% during the survey period. The mortality rate increased in the pastoralist regions of the country from 31 per 1,000 live births to 36 per 1,000 live births, compared to the city and agrarian regions. Maternal ANC visits in 2005 and 2016 (AOR [95%CI] = 0.10 [0.01, 0.81]; 0.01 [0.02, 0.60]) were significantly associated with neonatal mortality. In addition, the decomposition analysis revealed that changes in composition in the preceding birth intervals of more than 24 months and early breastfeeding initiation contributed to the reduction of neonatal mortality by 26% and 10%, respectively, during the survey period.Conclusion The study found that neonatal mortality is a public health problem in the country, particularly in pastoralist communities. Tailor made maternal and child healthcare interventions that promote early breastfeeding initiation, birth intervals and ANC utilization should be implemented to reduce neonatal mortality, particularly in pastoralist communities.
The association between mobile game addiction and mental health problems and learning outcomes among Thai youths classified by gender and education levels
Authors: Phetphum Chakkraphan , Keeratisiroj Orawan , Prajongjeep Atchara
Published: May 2023

Introduction: Youth are increasingly playing mobile games, which distinct from traditional games, but there is limited research investigating the causal relationship between mobile game addiction and mental health problems in Thailand. This cross-sectional study investigated the association between mobile game addiction and depression, loneliness, and social anxiety as well as academic performance.
Methods: Data were collected from 3,427 students in Thailand, using a 5-part self-report questionnaire. Descriptive statistics and Structural Equation Modelling (SEM) were used to analyse the data.
Results: The prevalence of mobile game addiction among Thai youth was 22.2%, which was higher among females (25.6%) than males (17.9%) and higher among high school students (25.6%) than vocational (20.6%) and undergraduate students (20.0%). According to the SEM analysis, mobile game addiction was significantly associated with depression (β = 0.36), loneliness (β = 0.31), social anxiety (β = 0.28), and Grade Point Average (GPA) mediated by social anxiety (β = 0.10).
Conclusion: The identification of a substantial group of addicted mobile gamers and the addiction effects on mental health issues supports efforts by all stakeholders to prevent youth from becoming game addicted as well as treat addicted gamers.
A rare case report of Thoracic Bony Human Tail In A New Born Baby And a Review of Literature
Authors: Deo Rama Chandra , Acharya Abhijit , Mahapatra Ashok K , Panigrahi Souvagya
Published: May 2023

The dorsal cutaneous appendage or so-called human tail, is considered to be a cutaneous marker of underlying occult dysraphism. We are presenting an unusual case of spinal dysraphism with a bony human tail at mid thoracic region occurring in a new born baby with tethered cord (conus at L4). Physical examination was unremarkable except for a thoracic appendage and a dermal sinus over coccyx region. Magnetic resonance imaging (MRI) scan of spine revealed bony outgrowth arising from D7 posterior element with multiple butterfly shaped vertebrae found at D2 D4 D8 D9 D10with low lying conus at L4-L5 level. Surgical excision of the tail and untethering the spinal cord along with excision of dermal sinus were performed. The infant had an uneventful postoperative period and was unchanged neurologically. To our knowledge, no similar case has been reported in English literature till date. The specific features of this rare case of human tail treated surgically are discussed in light of the available literature.
A Novel Hybrid Approach for Multi-class
Classification of Lung Related Diseases
Authors: Roy Manojeet , Baruah Ujwala
Published: May 2023

Of late, the whole world has seen an alarming impact due to the
widespread and rapid rise of Covid-19 cases. This paper addresses the
challenge of early and accurate detection of lung-related diseases, par-
ticularly Covid-19, Pneumonia, Lung-Cancer, and Normal chest images,
using hybrid deep learning models. The study evaluates the perfor-
mance of three hybrid deep learning architectures that use three feature
extraction models, namely InceptionV3, ReNet50, and Xception net Con-
volution Neural Network (CNN). The proposed hybrid models employ
recurrent neural networks, namely CNN-LSTM, CNN-GRU, and CNN-
BiGRU, for classification. The study uses both computed tomography
(CT) and chest X-ray (CXR) images to evaluate the models’ per-
formance. The CNN-BiGRU model achieved the highest accuracy of
99.57%, with an average sensitivity and precision of 99.00%, and an
F1-score of 99.00%. The study finds that the hybrid deep learning
strategy produces highly competitive accuracy while requiring modest
training time and loss for the classification of lung-related diseases.
Multivariate linear modeling of soil properties using soil formation factors
Authors: Pazhuhandeh Alireza , Torkashvand Ali Mohammadi , Moeini Abolfazl , Pazira Ebrahim
Published: May 2023

Parent material, climate, topography, time, and living organisms all play a role in soil formation. This study aimed to investigate the relationship between these factors and soil physicochemical properties for rapid management of watersheds and Multivariate linear modeling of soil properties using soil formation factors. Four watersheds of Qazvin province were studied, namely Juyank, Madan, Niyarak, and Plangeh. First, the working unit map was prepared using a geographical information system (GIS) on a scale of 1:25000 based on photogeological investigations and field visits. Then, 101 soil samples were collected and EC, pH, organic matter percentage, sand fraction, silt proportion, and clay percentages were measured. The relationship between soil formation factors and properties was investigated using linear multivariate regression in three methods of Enter, Forward, and Stepwise. Therefore, the 5 soil-forming factors were the independent variables, and the soil's physical and chemical characteristics were set as the dependent variables. The accuracy of these models was validated using two statistics of explanation coefficient and mean squared error (RMSE). The results demonstrated that the highest R2 value of 0.78 with an RMSE of 0.56 was associated with the relationship between pH and soil-forming factors (regression by the Enter method). There was less than a 50% correlation between silt, clay, and electrical conductivity with soil-forming factors.