bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS FAKTOR – FAKTOR PRODUKSI TERHADAP PENDAPATAN PENGUSAHA TAPE DI KELURAHAN LADANG BAMBU KECAMATAN MEDAN TUNTUNGAN
Authors: Tarigan Vani Eorita , Fadlan Ahmad
Published: July 2024

This research was conducted with the aim of analyzing production factors on the income of tape entrepreneurs in Ladang Bambu Village, Medan Tuntungan District. Using a quantitative approach method with a sample size of 60 respondents determined by Accidental Sampling. Data collected using the questionnaire method was then analyzed using multiple linear regression analysis in SPSS version 25.00. The results of this research show that partially labor and marketing influence the income of tape entrepreneurs in Ladang Bambu Village, Medan Tuntungan District. Meanwhile, business capital and location have no effect on the income of tape entrepreneurs in Ladang Bambu Village, Medan Tuntungan District. Furthermore, it simultaneously shows that labor, business capital, location and marketing together influence the income of tape entrepreneurs in Ladang Bambu Village, Medan Tuntungan District.
Factors Influencing Adoption of E-Commerce Innovation among Village Employees
Authors: Hadian Nur , Rizaludin Muhammad
Published: July 2024

This research investigates the factors that affect the adoption of e-commerce innovations by village government employees, who are crucial in developing village-owned enterprises (BUMDES). The study uses a literature review to explore the factors influencing the adoption of e-commerce by village employees. By searching for articles published between 2014 and 2023 in reputable journals like Scopus, EmeraldInsight, Science Direct, and EBSCOhost, 30 relevant articles were obtained. The research reveals that technological, economic, environmental, organisational, and trust factors have the greatest impact on the adoption of e-commerce in village governments. These findings can serve as a basis for future research on the effectiveness of these factors and can also assist policy makers and organizations in implementing effective strategies for e-commerce adoption by BUMDES in rural areas. This adoption is expected to have a positive impact on economic development and overall rural progress.
Analisis Proses Pengadaan Material dengan Pendekatan Simulasi di Perusahaan Listrik Negara (PLN)
Authors: Ali Muhammad , Hertadi Christopher Davito Prabandewa , Aprillia Happy , Muqimuddin Muqimuddin
Published: July 2024

PLN merupakan perusahaan negara yang bergerak di bidang pembangkitan dan penyaluran energi. Salah satu bagian dari PLN adalah PLTU Kaltim Teluk sebagai pembangkit energi listrik di Kalimantan Timur yang tentu melakukan proses pemeliharaan dan perbaikan mesin. Periode Juni-Juli 2023 terjadi penundaan pemeliharaan dan operasional karena keterlambatan pengadaan material dengan status belum selesai hanya 68%. Penelitian ini dilakukan untuk mengidentifikasi faktor yang menyebabkan keterlambatan proses pengadaan barang dengan memperhatikan utilitas dan waktu tunggu. Pemodelan simulasi digunakan sebagai metode penyelesaian karena memiliki efisiensi waktu dan mengurangi biaya besar dalam melakukan skenario perbaikan. Hasil simulasi aktual didapatkan total waktu tunggu sebesar 18,34 jam dengan tahap approving dan pembuatan dokumen TOR, FPB, dan RAB sebagai tahap waktu tunggu terbesar. Utilitas pada staff pembuatan FPB, TOR, RAB sebesar 13-62%, staff RO 6-55%, staff RKS 10-52%, staff PDP 0-45%, staff HPS 0-45%, staff PPP 0-44%, staff eval 4-41%, staff BA 0-56%, dan staff PO 8-52%.. Kemudian dikembangkan tiga skenario perbaikan, dengan skenario terbaik yaitu skenario pengurangan resource dan skenario peningkatan jumlah material pemesanan.
Perbandingan Enkripsi Advanced Encryption Standard dan Enkripsi Rivest Shamir Adleman
Authors: Nawawi Dyta Bagus , Huda Muhamat Maariful , Prabowo Tito
Published: July 2024

Pentingnya keamanan informasi tidak dapat diabaikan di era digital ini, dimana data yang ada sangat rentan terhadap ancaman keamanan. Kondisi ini muncul karena semakin cepat perkembangan teknologi informasi saat ini diiringi pula dengan semakin rentannya keamanan data yang berharga dan harus dilindungi. Oleh karena itu, sistem keamanan yang tinggi sangat diperlukan. Enkripsi yang mampu memberikan jaminan keamanan dan sering digunakan yaitu enkripsi AES dan RSA. Penelitian ini membandingan kecepatan mengenkripsi pada dua metode enkripsi AES dan RSA. Berdasarkan hasil yang didapat kedua enkripsi AES dan RSA memiliki kecepatan yang berbeda. Percobaan ini dilakukan menggunakan 5 file yang berbeda. Hasil yang didapat rata-rata waktu kecepatan enkripsi AES  0,23788 ms. Sedangkan, pada rata-rata waktu kecepatan yang dibutuhkan enkripsi RSA 13,2072 ms. Berdasarkan catatan waktu kecepatan kedua enkripsi AES lebih cepat dibanding RSA.
Analisis Sentimen Pengguna YouTube Tentang Rohingya Menggunakan Algoritma SVM (Support Vector Machine)
Authors: Hidayat Hidayat , Santoso Firman , Lidimillah Lukman Fakih
Published: July 2024

YouTube merupakan platform yang banyak digunakan masyarakat Indonesia, tentu karena terdapat konten-konten yang selalu diperbarui mengikuti berita terkini di Indonesia, salah satunya kasus pengungsi dari Rohingya. Kasus pengungsi Rohingya menimbulkan perbincangan yang luas di platform YouTube di Indonesia. Dalam penelitian ini, kami menerapkan text mining untuk menganalisis komentar-komentar yang muncul terkait topik tersebut. Metode SVM dipilih untuk analisis sentimen karena kepopulerannya dan tingkat akurasi yang tinggi. Langkah-langkah meliputi pengumpulan data, pra-pemrosesan data, dan penerapan SVM untuk klasifikasi. Hasilnya menunjukkan akurasi sebesar 77%, dengan recall 100% dan precision 77%. Temuan ini memberikan wawasan tentang sentimen masyarakat terhadap kasus Rohingya di YouTube. Metode SVM terbukti efektif dalam mengorganisir komentar-komentar yang tidak terstruktur. Penelitian ini dapat menjadi landasan untuk memahami opini dan sikap masyarakat terkait isu ini secara lebih mendalam.
Klasifikasi Kematangan Citra Buah Tomat Berdasarkan Ekstraksi Fitur Warna Menggunakan Metode K-NN
Authors: Widat Ahmad Badri Maulana , Baijuri Achmad , Lazim Farihin
Published: July 2024

Salah satu bahan pangan pokok bernilai ekonomi tinggi yang banyak dikonsumsi masyarakat umum adalah solanum hycopersium, juga dikenal sebagai tomat. Namun, umur penyimpanan dan kualitas produk tomat sangat penting, karena proses pematangan tomat memiliki waktu yang singkat, untuk menyelesaikan masalah ini, peneliti menggunakan metode K-NN untuk mengklasifikasikan kematangan buah tomat berdasarkan ekstraksi fitur warna. Dalam proses klasifikasi tingkat kematangan buah tomat ini, 150 dataset digunakan, terdiri dari 50 buah matang, 50 mengkal, dan 50 mentah. Dari 150 dataset ini, 90 data latih dan 60 data uji digunakan. Hasil klasifikasi K-NN menunjukkan nilai optimal pada k=5 dengan akurasi 98.33%, akurasi tersebut dihasilkan dari 60 data yang diuji hanya 1 yang diklasifikasi salah dan 59 data diklasifikasi benar.
Penerapan Kansei Engineering Dalam Desain Ulang Kemasan Kue Tambang di UMKM Sumber Jaya
Authors: Yasin Muhammad Alvian , Hakim Afif , Perdana Mohammad Fadli
Published: July 2024

Sumber jaya merupakan UMKM yang memproduksi kue tambang, Produk kue tambang saat ini menggunakan kemasan yang kurang menarik serta masih menggunakan kemasan yang biasa dipergunakan oleh produk sejenis. Salah satu komponen paling penting dari sebuah produk yaitu kemasan. Penelitian ini dilatar belakangi oleh potensi pasar UMKM kue tambang dan kebutuhan untuk merancang ulang kemasan produk guna meningkatkan daya tarik konsumen. Hasil survei menyatakan 96,7% responden setuju untuk dilaksanakan pengembangan kemasan pada kemasan kue tambang. Pada penelitian ini mempergunakan metode kansei engineering karena metode ini meyakinkan barang ataupun jasa memenuhi respon emosional yang diinginkan oleh konsumen yang kemudian diterjemahkan ke dalam parameter desain. Desain baru hasil dari pendekatan kansei engineering yaitu X1.2 (warna: satu warna), X2.1 (jenis penutup: non ziplock), X3.2 (jenis kemasan: standing pouch), X4.1 (gambar kemasan: ikon kue tambang).
Penilaian Pelaksanaan Pemeliharaan dan Perawatan Bangunan Hotel di Sleman Yogyakarta
Authors: Sari Sely Novita , Maulana Rizal , Hermawan Anggi , Ardian Oggi Heicqal
Published: July 2024

Pemerintah telah menetapkan pedoman melalui Peraturan Menteri Pekerjaan Umum No. 24/PRT/M/2008 mengenai pemeliharaan dan perawatan bangunan Hotel. Pedoman ini bertujuan untuk mengurangi kerusakan dan masalah pada konstruksi bangunan dari segi kualitas, fasilitas, dan keamanan, serta mempermudah penanganan jika terjadi kerusakan. Pengamatan struktural bangunan memerlukan pengujian yang cermat. Penelitian ini menilai pemeliharaan dan perawatan Hotel sesuai peraturan tersebut. Hasilnya menunjukkan bahwa dari enam hotel yang diperiksa, pelaksanaan pemeliharaan bangunan mencapai 55,57%, sementara pelaksanaan perawatan mencapai 63,39%. Penelitian ini membantu menilai sejauh mana pedoman tersebut diterapkan dan dipahami di lapangan
Estrategias efectivas para el aprendizaje de Inglés en el bachillerato
Authors: Apunte-Pupiales Jorge , Atis-Chapi Erika
Published: July 2024

El presente estudio se enfoca en analizar el impacto de las prácticas pedagógicas en el rendimiento académico de estudiantes de tercer año de bachillerato en el área de inglés. El objetivo principal consiste en identificar estrategias que mejoren las habilidades orales, escritas, de escucha y lectura en inglés de los estudiantes de tercer año de bachillerato, buscando proporcionar un marco práctico y adaptativo para la implementación de estas estrategias en la Unidad Educativa 11 de Julio. La investigación se realiza mediante un enfoque cualitativo de corte transversal, recopilando datos a través de observaciones, entrevistas y análisis documental. La población de estudio incluyó a 39 estudiantes de la especialidad de Informática. La implementación de estrategias como la gamificación, uso de técnicas constructivistas, y fomento de la participación en actividades colaborativas, ha generado un progreso significativo en las cuatro habilidades del inglés, demostrando ser altamente efectivas, considerando que se observó un aumento significativo en la participación, así como mejoras notables en las habilidades orales, escritas, de escucha y lectura en el idioma inglés. En este sentido, los resultados se respaldan con cifras que indican progresos específicos en cada habilidad lingüística. Las conclusiones resaltan el positivismo de los estudiantes hacia las metodologías utilizadas, resaltando la importancia de adaptar la enseñanza a las preferencias y necesidades de la generación actual; asegurando así su aprendizaje. La propuesta de evaluación crítica y mejora continua asegura la sostenibilidad y evolución del proceso educativo, mediante estrategias innovadoras, fomentando la participación y promoviendo un ambiente de aprendizaje estimulante y comprometido.
ChatGPT como herramienta pedagógica en la metodología de Aprendizaje Basado en Proyectos
Authors: Cajo-Torres Maria , Ochoa-Icaza Sonia , Marín-Figuera María , Yánez Cando Xavier Oswaldo
Published: July 2024

La aparición de la inteligencia artificial resulta una oportunidad para mejorar los procesos de aprendizaje, sobre todo, en un mundo donde la información cada día es mayor, y se requieren herramientas que favorezcan su procesamiento y uso pedagógico. En consecuencia, la presente investigación tiene como objetivo analizar la incidencia del uso del ChatGPT como herramienta pedagógica a través de la metodología de Aprendizaje Basado en Proyectos. El estudio se realizó a partir de un diseño de investigación cuasiexperimental, que evalúo el desempeño de una actividad de aprendizaje de la asignatura de Emprendimiento y Gestión, para la que se conformaron dos grupos, uno de experimento que utilizó ChatGPT para el desarrollo de la actividad, y otro de control, que realizó la actividad de forma tradicional sin el uso de la tecnología. La muestra fue no probabilística de tipo convencional, correspondiente a 80 estudiantes de Tercero de Bachillerato. De acuerdo a los resultados obtenidos se visualiza de manera significativa la eficacia del uso del ChatGPT como herramienta pedagógica en el contexto del Aprendizaje Basado en Proyectos. El grupo de experimento, que empleó ChatGPT para el desarrollo de la actividad de aprendizaje en la asignatura de Emprendimiento y Gestión, exhibió un rendimiento notablemente superior en cada uno de los indicadores estudiados en comparación con el grupo de control, concluyendo que el uso de la tecnología brinda perspectivas valiosas para mejorar las estrategias de enseñanza en el ámbito de Emprendimiento y Gestión.
La calidad del servicio y la satisfacción del cliente en la Empresa CNEL EP Manabí
Authors: Botines-Carreño Felicita , Briones-Saltos Luis
Published: July 2024

La calidad del servicio que ofrece una empresa influye directamente en la satisfacción del cliente, de allí la importancia de la mejora continua enfocada en el consumidor. Determinar la percepción de la calidad del servicio y la satisfacción del cliente en la empresa CNEL EP de la ciudad de Manta, consistió el objetivo de investigación. Como metodología se empleó el cuestionario SERvice PERFormance de 5 dimensiones, y 22 preguntas sobre la percepción de la calidad del servicio que fue aplicado a una muestra no probabilística intencional de 50 clientes. Los resultados revelaron una alta percepción de la calidad en las dimensiones de aspectos tangibles, fiabilidad, capacidad de respuesta, seguridad y empatía, la satisfacción fue calificada como alta. Concluyendo en que la percepción de la calidad del servicio por los clientes de CNEL tiende a ser alta y esto influye en la satisfacción que sienten por el servicio recibido, sustentado en la seguridad que perciben cuando visitan las instalaciones; la fiabilidad que le proporciona el personal al otorgar el servicio prometido y la tangibilidad que percibe sobre el aspecto impecable del personal y de la infraestructura que posee la empresa.
Control de gestión y fidelización de clientes de la empresa eléctrica Unidad de negocios Manabí
Authors: Delgado-Cobeña Yosimar , López-Mera Laura
Published: July 2024

La fidelización del cliente se logra cuando la relación empresa-consumidor es leal y positiva, y se logra cuando los resultados del control de la gestión indica que debe invertirse servir al cliente. El objetivo del trabajo se centró en determinar la influencia del control de gestión en la fidelización de clientes de la Empresa Eléctrica Unidad de negocios Manabí; se aplicó el enfoque mixto mediante un cuestionario de encuesta categorizado en 3 dimensiones a una muestra intencional de 200 clientes. Se obtuvo como resultados una mayoría de clientes que respondieron a un enfoque conductual de fidelización en nivel alto, un enfoque de satisfacción global bueno, un alto enfoque de confianza en cuanto a sentirse satisfecho como empresa, se fía y confía, y recibe respuesta a las quejas, preguntas y reclamos; la energía más barata y la solución de problemas fueron las opciones escogidas por toda la muestra de clientes encuestados. Se concluye en la necesidad de fortalecer la atención al cliente en cuanto a quejas y reclamos en las oficinas, así como la resolución de problemas de manera más ágil.
Argumentación lógica en la resolución de tenencia y el principio de interés superior del niño
Authors: Alvarez-León Diego
Published: July 2024

La tenencia como un atributo de la patria potestad, hace referencia al derecho que tiene el progenitor para vivir con el niño asumiendo la responsabilidad de su crianza, atención y cuidados. Luego que los padres se separan y no existe acuerdo entre ellos para ejercer la tenencia de los hijos, esta es resuelta por el juez de familia quien dictará medidas, salvaguardando el interés superior, y recurriendo a la argumentación lógica. Este artículo analiza la argumentación aplicada por los jueces de familia y que es utilizada para tratar de convencer, con argumentos conformados por premisas para tutelar el interés superior de niño. Esta investigación tuvo como objetivo realizar un análisis crítico jurídico respecto a la argumentación lógica utilizada en la Unidad Judicial de Familia de Latacunga en los años 2022. Se recurrió al método de análisis documental, bibliográfico, analítico sintético y descriptivo, analizando resoluciones emitidas de tenencia en los años descritos y planteando entrevistas a tres jueces de la localidad que se valora como juicio de expertos En tal sentido, el resultado evalúa la aplicación de la argumentación lógica dentro de los juicios de tenencia y su incidencia en el interés superior del niño.
La falsificación de medicamentos en África desde el derecho penal económico
Authors: Coronel-Idrovo Andrea
Published: July 2024

El presente estudio sobre la falsificación de medicamentos en África, con especial atención a los tratamientos adulterados para tratar el VIH, se relaciona con el derecho penal económico en cuanto el intervencionismo estatal en la economía es una realidad que tiene la necesidad de “precautelar los intereses éticos-sociales perfectamente reconocidos en todo estado moderno”, sin olvidarse que se encuentra ligado a la corrupción y la lucha contra aquel problema.  
Es importante señalar que el Derecho Penal Económico tiene origen a finales del siglo XIX y se consolida en el XX, inicia políticamente con el cambio del sistema agrario al sistema industrial, en donde se empieza a generar ideas de un estado interventor en la economía, controlando la producción, distribución y consumo de bienes a gran escala como consecuencia del sistema industrial. Jurídicamente, se ha expresado que su nacimiento se produce con la Constitución de Weimar, siendo la primera constitución en hablar sobre relevancia económica y generar disposiciones de orden económico, derecho constitucional económico que se entiende “el conjunto de normas básicas destinadas a proporcionar el marco jurídico fundamental para la estructura y el funcionamiento de la actividad económica o, dicho de otro modo, para el orden y el proceso económico.” 
Las características principales que distinguen el derecho penal económico son de prevalencia accesorio en cuanto “la legislación que lo recepta se encuentra mayoritariamente esparcida en leyes de otras ramas jurídicas”, tal es el caso del código tributario o código de la salud. Además de su característica dinámica y variable, entendiendo que las modificaciones legales de códigos que regulan conductas sociales siguen el ritmo de la trasformación social, buscando castigar actos intolerables, estas características esenciales del derecho penal económico se relaciona con la falsificación de medicamentos y sobre el tratamiento del VIH/SIDA, en el sentido que si bien existe normativa sobre la falsificación de medicamentos en el Código Orgánico Integral Penal ecuatoriano esto es el art. 217, no es menos cierto que al existir este tipo penal debemos remitirnos al código y reglamentos sobre la producción de medicamentos que traer el código de salud, incluso para conocer y comprender que conlleva una falsificación, cumpliéndose la característica de prevalencia accesoria; sobre el tema de dinámica y variable es fácil entender el rechazo social que produce la falsificación de medicamentos y más aún sobre una enfermedad crónica y únicamente controlable, como el VIH/SIDA. Del porque existe en nuestro COIP normada aquella conducta incluso con agravantes sobre este tipo de acciones reconociéndose su dinámica es este tópico.
Estrategias de marketing para el posicionamiento de emprendimientos digitales
Authors: Tello-Rivera Gina , Feijó-Cuenca Tito
Published: July 2024

Las estrategias de marketing crean oportunidades, establecen la organización y la planificación que conlleva a posicionarse en el mercado; el objetivo del estudio consistió en caracterizar las estrategias de marketing que influyen en el posicionamiento de emprendimientos digitales. Se aplicó el enfoque cualitativo mediante la revisión documental realizada desde el buscador de Google Académico en bases de datos indizadas y páginas web, seleccionándose 47 fuentes de información con una media de 91% de actualidad. Se identificaron 37 tipos de estrategias de marketing digital, 10 herramientas de marketing digital enfocadas al posicionamiento de emprendimientos digitales como Inbound marketing, Content marketing, SEO optimizado, Social media marketing, entre otras, y 16 formas de posicionamiento de emprendimientos digitales: basado en la competencia, en los atributos, en los beneficios del producto, en el uso o aplicación, en el usuario, en la calidad del producto o servicio, en el precio o valor, en un estilo de vida, reposicionamiento de marca, en la consecuencia, en las características del público objetivo, en las características propias de la marca. Concluyéndose que, las estrategias del marketing digital contribuyen al posicionamiento de emprendimientos digitales en el mercado, siendo las redes sociales una herramienta importante para el éxito de la estrategia digital.
Citación telemática y derecho a la defensa de las personas adultas mayores en el ordenamiento jurídico ecuatoriano
Authors: Wong-Vivas Nixon , Cadena-Ramírez Maria
Published: July 2024

El presente artículo hace un estudio de derechos constitucionales como el derecho a defensa y el debido proceso frente a la citación telemática enfocada a los adultos mayores. La citación telemática se encuentra dada a la reforma del Código Orgánico General de Procesos, publicado mediante Ley s/n, R.O. 245-3S, 7-II-2023, que introduce esta nueva modalidad de citación, la misma que acarrea una serie de vulneraciones a los derechos establecidos en la Constitución de la República del Ecuador hacia los adultos mayores como grupo de atención prioritaria que se encuentren inmersos en un proceso judicial.
            La citación telemática establece la construcción de un buzón electrónico ciudadano al cual se les notificará las demandas a las personas naturales. Dicho procedimiento atenta los derechos de los adultos mayores, vulnerando el debido proceso y el derecho a la defensa puesto que la carencia de conocimientos sobre el desarrollo de las nuevas tecnologías y la instauración de buzones electrónicos personales para recibir notificaciones legales, fragmenta la seguridad de permitirles a los adultos mayores ejercer una defensa adecuada por falta de conocimiento de uso de medios electrónicos.
Wawasan Al-Qur’an tentang Pendidikan dan Pengajaran
Authors: Mursalin Hisan
Published: July 2024

The important aspect of human life is education. Through education, a person can develop their potential andunderstanding of the world around him can be developed through education. In Islam, education has a very important role. The Al-Quran as the holy book of Muslims provides guidance and guidance in living life, including in matters of education. Education in the vision of the Al-Quran aims to guide individuals to achieve spiritual, moral and intellectual perfection, as well as forming a just, harmonious and prosperous society. This research uses a literature review approach which focuses on data collection and comprehensive analysis of material or theories from various sources, including articles related to the topic discussed. The Al-Qur'an provides insight into education and teaching by emphasizing the importance of knowledge, morals and holistic self-development. This includes moral, scientific, social, and spiritual learning to form individuals who have noble character, are knowledgeable, and contribute positively to society. Thus, education in the insight of the Al-Quran is very important in the lives of Muslims. Through the Al-Quran, we can learn good life values ​​and apply them in everyday life. As Muslims, we should understand and practice the teachings of the Al-Quran in living this life. Hopefully, with education in the insight of the Al-Quran, we can become good individuals and be useful to society.
End-Stage Renal Disease and Neurological Connection
Authors: Choudhary Raj , Singh Amrendra , Raman Ravi , Perwaz Anjum
Published: July 2024

Due to the incapacitating nature of end-stage renal disease, people on dialysis frequently acquire undetected psychopathological disorders. This may affect the effectiveness of treatment for a chronic disease. Dialysis is a therapy for kidney failure, but not a cure. As a result of the treatment plan and other restrictions, the patient is forced to make several significant modifications to their daily routines and activities, which in turn has an impact on their ability to socialise and mentally operate. There is a high rate of morbidity and mortality in individuals with renal failure due to neurological complications. Dialysis may not be effective in treating many of the neurological effects of uraemia, such as uraemic encephalopathy, atherosclerosis, neuropathy, and myopathy, despite ongoing improvements in therapy. Brain networks are destroyed in patients on haemodialysis with end-stage renal disease.
Population demographic tracking and estimation tool: a simulation-dashboard for urban redevelopment’s demographic implications in Israel
Authors: Levine Daphna , Sussman Shai , Aharon-Gutman Meirav , Yavo Ayalon Sharon
Published: July 2024

This research introduces a pioneering methodology and user-friendly online dashboard for examining population shifts during urban redevelopment in Bat Yam, Israel, part of the Tel Aviv Metropolitan Area. The simulation tool, operated through scripts, predicts how redevelopment scenarios will impact household demographics over time. Its output is a population track-change CSV file detailing demographic changes. The accompanying online dashboard visually presents these changes, making the data accessible to policymakers and planners. The tool’s consideration of environmental factors enhances its applicability in identifying vulnerable populations and resilient communities amidst urban renewal. This user-friendly approach, compatible with existing planning tools, underscores the article’s significance in advancing urban planning practice and addressing societal needs.
Understanding perceptions that drive conflict over the endangered Hawaiian monk seal
Authors: Konrad Leilani , Levine Arielle , Leong Kirsten Mya , Koethe Francesca
Published: July 2024

As conservation and management actions facilitate the recovery of threatened and endangered marine species, and human populations expand in urbanizing coastal areas, people are increasingly coming into contact with marine wildlife. These increasing human-wildlife interactions can cause conflict, as has been the case with the endangered Hawaiian monk seal. Since 2009, there have been at least sixteen documented monk seal killings by gunshot or head trauma. Drawing on interviews, surveys, and government and media reports, we explored the underlying drivers behind this conflict, examining how social construction of wildlife, levels of conflict, and ideas from risk communication inform these drivers. Across these sources, we found that most people on beaches where seals are present and other members of the public hold positive perceptions of monk seals and are not engaged in conflicts. Rather, conflict is driven by individuals who have strong feelings about seals and what they represent, which in some cases conflicts with their own values and sense of identity. Many monk seal recovery volunteers saw themselves as protectors of endangered seals, seeing the species as an innocent victim of human-caused environmental destruction. Some fishermen viewed seals as resource competitors, and there were those who also saw them as symbolic of federal government restrictions on access to natural resources. Native Hawaiians who disliked seals saw them as invaders in their native homeland, and perceived federal actions to protect seals as a continuation of colonial restrictions on their rights and access. Social media and other platforms also play an emerging role in escalating the conflict over monk seals. Natural resource managers have engaged in multiple intervention strategies to address conflict, including message framing, education and outreach, and efforts to increase public trust. However, these efforts have not always targeted the people most likely to interact with monk seals as populations recover. Ultimately, it is important for resource managers to articulate their own assumptions and values, and to work to understand the assumptions and values of those who may be affected by successful monk seal recovery efforts, to develop effective strategies that prevent and address conflict over this recovering endangered species.
Thromboaspiration of a left-sided bioprosthetic valve thrombosis by a mini-access: the Lausanne novel procedure
Authors: Gunga Ziyad , Rubimbura Vladimir , Oberson Denise , Monney Pierre , Bechtold Xavier , Ltaief Zied , Rancati Valentina , Eeckhout Eric , Kirsch Matthias
Published: July 2024

Left-sided bioprosthesis valve thrombosis (LSBVT) is a challenging complication necessitating invasive interventions. In this study, we introduce a novel, minimally invasive approach. We used a cerebral embolic protection system and an Occlutech cannula connected to an extracorporeal circuit, providing safer thrombus aspiration compared to the AngioVac system. This technique offers a promising alternative for high-risk patients with LSBVT.
Causal associations between chronic heart failure and the cerebral cortex: results from Mendelian randomization study and integrated bioinformatics analysis
Authors: Peng Liqi , Cai Huzhi , Tang Yanping , Zhou Fang , Liu Yuemei , Xu Zelin , Chen Qingyang , Chen Xinyu
Published: July 2024

Background

Chronic heart failure (CHF) patients exhibit alterations in cerebral cortical structure and cognitive function. However, the mechanisms by which CHF affects cortical structure and functional regions remain unknown. This study aims to investigate potential causal relationship between CHF and cerebral cortical structure through Mendelian randomization (MR).

Methods

The research utilized genome-wide association studies (GWAS) to explore the causal association between CHF and cerebral cortical structure. The results were primarily analyzed using the inverse-variance weighted (IVW). The reliability of the data was verified through horizontal pleiotropy and heterogeneity analysis by MR-Egger intercept test and Cochran's Q-test, respectively. Replication analysis was conducted in the Integrative Epidemiology Unit (IEU) OpenGWAS project for further validation. In addition, we collected mediator genes that mediate causality to reveal potential mechanisms. Integrated bioinformatics analysis was conducted using the Open Target Genetics platform, the STRING database, and Cytoscape software.

Results

The IVW results did not reveal any significant causal association between genetically predicted CHF and the overall structure of the cerebral cortex or the surface area (SA) of the 34 functional regions of the cerebral cortex (P > 0.05). However, the results revealed that CHF increased the thickness (TH) of pars opercularis (IVW: β = 0.015, 95% CI: 0.005–0.025, P = 3.16E-03). Replication analysis supported the causal association between CHF and pars opercularis TH (IVW: β = 0.02, 95% CI: 0.010–0.033, P = 1.84E-04). We examined the degree centrality values of the top 10 mediator genes, namely CDKN1A, CELSR2, NME5, SURF4, PSMA5, TSC1, RPL7A, SURF6, PRDX3, and FTO.

Conclusion

Genetic evidence indicates a positive correlation between CHF and pars opercularis TH.
Cognitive biases in pediatric cardiac care
Authors: Padovani Paul , Roy Arnaud , Guerra Amanda , Cadeau Olivier , Ly Mohamed , Vasile Corina M. , Pass Robert H. , Baruteau Alban-Elouen
Published: July 2024

Medical practitioners are entrusted with the pivotal task of making optimal decisions in healthcare delivery. Despite rigorous training, our confidence in reasoning can fail when faced with pressures, uncertainties, urgencies, difficulties, and occasional errors. Day-to-day decisions rely on swift, intuitive cognitive processes known as heuristic or type 1 decision-making, which, while efficient in most scenarios, harbor inherent vulnerabilities leading to systematic errors. Cognitive biases receive limited explicit discussion during our training as junior doctors in the domain of paediatric cardiology. As pediatric cardiologists, we frequently confront emergencies necessitating rapid decision-making, while contending with the pressures of stress, fatigue, an earnest interest in “doing the right thing” and the impact of parental involvement. This article aims to describe cognitive biases in pediatric cardiology, highlighting their influence on therapeutic interventions for congenital heart disease. Whether future pediatric cardiologists or experienced professionals, understanding and actively combating cognitive biases are essential components of our ongoing medical education. Furthermore, it is our responsibility to thoroughly examine our own practices in our unwavering commitment to providing high-quality care.
Temperature-dependent carbon isotope fractionation in coccolithophores
Authors: Torres-Romero Ismael , Clark Alexander J. , Wijker Reto S. , Jaggi Madalina , Zhang Hongrui , Stoll Heather M.
Published: July 2024

Introduction: The stable carbon isotope ratio of long-chain alkenones produced by marine haptophyte phytoplankton has often been used to estimate past variations in atmospheric CO2 throughout the Cenozoic. However, previous experimental studies and surveys of alkenones from surface sediment and suspended particulate matter document additional environmental and physiological influences on carbon isotopic fractionation in alkenones.

Methods: To clarify the non-CO2 effects on the alkenone carbon isotope fractionations, an important alkenone producer, Gephyrocapsa oceanica, was cultured in laboratory. To separate effects of different environment parameters, G. oceanica was grown in continuous cultures under a matrix of environmental conditions in order to explore the influence of temperature independently of CO2(aq). Through careful manipulation of the media carbon system, we can control the variation of the media CO2(aq) independently of temperature solubility. Carbon isotope fractionations from alkenones, coccolith, and particulate organic carbon were measured from this steady state system.

Results and Discussion: We find εp in alkenones and particulate organic carbon inversely correlates with temperature, and temperature affects εp more strongly than CO2(aq). The magnitude of the temperature effect can be explained by higher growth rates at warmer temperatures with a similar growth rate dependence as observed in previous cultures in which growth rate was regulated by other factors. Where the past temperature influence on growth rate could be constrained using the UK’37 alkenone index in the same samples, our finding offers an approach to deconvolve an important physiological factor affecting ancient alkenones εp, and may therefore improve past pCO2 estimates.
The role of flourishing in the STEM trajectories of emerging adults
Authors: Hammerness Karen , Chaffee Rachel , Bjorklund Peter , Hinton Priya-Syrina Li , Daly Alan J. , MacPherson Anna , Gupta Preeti , Adams Jennifer D. , Braverman Coral , Francis Jahneal , Lagodich Lucie , Wu Lois , Abouelkheir Mahmoud
Published: July 2024

We focus on the use of flourishing as a new measure in studies of pathways in STEM (science, technology, engineering, and mathematical) fields. While the concept of flourishing is promising, the concept may need careful interrogation to ensure it takes structural and personal (cultural, religious, socioeconomic, and racial) differences into account. Our longitudinal study explores emerging adult’s educational and career pathways with careful attention to structural inequities, enabling us to productively explore the concept of flourishing in a larger systemic context. Drawing from a set of qualitative interviews with our participants, we explore the ways that our sample of emerging adults (N = 30), predominantly people of color, define and discuss flourishing. The concept resonated with our diverse participants, and a substantial number did report flourishing. But despite the regularity with which the participants described experiencing racism and microaggressions, they did not often mention those harmful experiences when discussing flourishing. We caution that flourishing data on its own may provide an overly rosy image of the pathways and development, especially of young people of color. Our data suggest that it may be especially important to examine flourishing in context with other measures that can flesh out a fuller picture of well-being, especially in relation to race, racism, sexism, or any other experiences related to personal identities. In particular, instruments should be carefully designed to ensure–especially for emerging adults–that all aspects of their lives and identities can be fully understood.
Unveiling the role of ferroptosis in the progression from NAFLD to NASH: recent advances in mechanistic understanding
Authors: Yu Qian , Song Lixing
Published: July 2024

Non-alcoholic fatty liver disease (NAFLD) is a prevalent and significant global public health issue. Nonalcoholic steatohepatitis (NASH) represents an advanced stage of NAFLD in terms of pathology. However, the intricate mechanisms underlying the progression from NAFLD to NASH remain elusive. Ferroptosis, characterized by iron-dependent cell death and distinguished from other forms of cell death based on morphological, biochemical, and genetic criteria, has emerged as a potential participant with a pivotal role in driving NAFLD progression. Nevertheless, its precise mechanism remains poorly elucidated. In this review article, we comprehensively summarize the pathogenesis of NAFLD/NASH and ferroptosis while highlighting recent advances in understanding the mechanistic involvement of ferroptosis in NAFLD/NASH.
Occurrence of 80 per and polyfluorinated alkyl substances (PFAS) in muscle and liver tissues of marine mammals of the St. Lawrence Estuary and Gulf, Quebec, Canada
Authors: Khalid Nejumal Kannankeril , Le Calvez Maud , Lemire Mélanie , Dinh Quoc Tuc , Fontaine Justine , Lair Stéphane , Sauvé Sébastien
Published: July 2024

Limited data are available for the occurrence of more recent per and polyfluorinated alkyl substances (PFAS) in marine mammals, especially from the St. Lawrence Estuary and Gulf. This study investigates the occurrence of PFAS in liver and muscle tissues of various marine mammals, including the harbor seal, gray seal, harp seal, hooded seal, harbor porpoise, white-sided dolphin, white-beaked dolphin, and True’s beaked whale. Among the 80 target PFAS (including PFCAs, PFSAs, Cyclic PFSA, FASAs/FASAAs, FTCAs/FTUCAs, FTSAs, Ether-PFAS, diPAPs, and ESI + ECF precursors) perfluorooctanoic sulfonate (PFOS) dominates in all the marine mammal species and several other long-chain PFCAs, such as PFNA, PFDA, PFUnA, PFTrDA, and PFHxDA, were detected at 100% frequency in both muscle and liver samples. PFDoA and 7:3 fluorotelomer carboxylic acid (7:3 acid) also showed a 100% detection frequency for liver samples. Harp seal tissues displayed notably low PFAS concentrations, with average total PFAS concentrations of 7 ng/g (ww: wet weight) in muscle and 44 ng/g (ww) in the liver. In contrast, the white-sided dolphin exhibited the highest average concentrations, reaching 39 ng/g (ww) in muscle and 334 ng/g (ww) in liver samples. The Pearson correlation analysis reveals a strong correlation between the concentration of PFOS, perfluoroalkyl carboxylic acids (PFCAs), and electrochemical fluorination (ECF) precursors. Species at the top of the marine food chain (harbor porpoise, white sided dolphin, and white beaked dolphin) presented the highest concentrations of PFAS, particularly PFOS and long-chain PFCAs, highlighting the need for an increased regulation of these persistent molecules in order to protect marine mammal’s health.
Effects of phytoplankton diversity on resource use efficiency in a eutrophic urban river of Northern China
Authors: Ma Mengdi , Li Jiaxin , Lu Aoran , Zhu Peixun , Yin Xuwang
Published: July 2024

Freshwater biodiversity has been declining in urban areas, which may threaten ecosystem functions. Although many studies have demonstrated a positive correlation between biodiversity and ecosystem functioning (BEF) in terrestrial and marine ecosystems, little is known about the BEF relationship in freshwater environments, especially in highly urbanized regions where water pollution is a major concern. Eutrophication in urban water bodies may trigger algae blooms, decreasing the evenness or functional divergence (FDiv) of phytoplankton communities, thus negatively affecting ecosystem functioning. Through an annual field investigation, we clarified the relationship between phytoplankton diversity and ecosystem functioning, represented as resource use efficiency (RUE), in an urban river in northern China. Results indicated that evenness in the phytoplankton community contributes most to driving ecosystem functioning compared to environmental factors. The relative abundance of dominant Bacillariophyta was positively correlated with the resource use efficiency of phytoplankton (RUEpp) but negatively correlated with the resource use efficiency of zooplankton (RUEzp). Both phytoplankton evenness and functional divergence were negatively linked to RUEpp but positively to RUEzp. Our findings suggest that the reduction of phytoplankton evenness and functional divergence may seriously threaten resource use efficiency (RUE), and its potential mechanism can provide a crucial reference for water quality protection and sustainable water resource utilization in the basin.
Has the development of the digital economy raised or lowered the level of carbon emissions in cities?-Evidence from China
Authors: Liu Mingxuan
Published: July 2024

This paper studies the impact of digital economy development on carbon emissions, which is a hot topic in the field of environmental economics. This topic is within the scope of the Frontiers in Environmental Science and is particularly in line with the theme of Environmental Economics and Management section in the journal. Firstly, this paper constructs the Digital Economy Development Index and its variable indicators to measure the development of the digital economy. Secondly, this paper uses urban panel data to reveal the impact of digital economy development on carbon emissions, and further adopts IV method to deal with endogeneity issues. Thirdly, this paper performs the heterogeneity analyses depending on the characteristics of the city. The results can provide a basis for formulating differentiated policies. Fourthly, this paper further explores the mechanism by which the digital economy affects carbon peaking. The results show that the digital economy may influence carbon peaking through upgrading of the industrial structure, technical innovation, and energy consumption.
Seed enhancements to improve direct-seeding outcomes for native grasses in mine restoration
Authors: Berto Bianca , Ritchie Alison L. , Erickson Todd E.
Published: July 2024

Seed-based restoration in dryland environments is commonly limited by low and sporadic rainfall, extreme temperatures, and degraded soils. These challenges are exacerbated in dryland mine restoration sites where species are seeded onto mine waste substrates due to limited availability of topsoil. Native grasses are focal dryland and mine restoration species, though the ability to deliver seeds to targeted sites presents further constraints to seed-based restoration due to complex seed morphology and site attributes. Seed enhancement technologies (SETs) may help to mitigate environmental stressors and improving seed handling. In this study, SETs which promote seedling recruitment and/or address edaphic challenges while also improving seed morphology and handling were tested in four Australian native grasses (Cymbopogon ambiguus, C. obtectus, Eulalia aurea, and Eriachne obtusa). Flash flaming or acid digestion (depending on species), extruded seed pellets with or without the addition of topsoil, and flaming or acid digestion used in combination with extruded pellets (with or without topsoil) were evaluated on topsoil and mine waste substrates. Material treated with either flash flaming or acid digestion tended to produce similar maximum emergence (week 3), final emergence (week 14), and above-ground biomass (week 14) on both topsoil and mine waste when compared to the un-enhanced (‘control’) treatment. Extruded pellets enhanced emergence (maximum and final) on both soil types, though had no effect on biomass. Extruded pellets containing topsoil and/or when used in combination with flash flamed or acid digested florets, provided the most significant benefits to seedling emergence, particularly on mine waste soil. However, SETs were unable to mitigate the detrimental effects of mine waste substrates on seedling biomass. This study shows promise for improving seed-based restoration in post-mine and dryland environments using SETs, though also highlights potential limitations and the importance of understanding long-term (i.e., beyond emergence) plant recruitment outcomes in SET applications.
Nephrotoxicity of targeted therapy used to treat lung cancer
Authors: Li Qiuling , Lin Jieshan , Hao Guojun , Xie Aihua , Liu Shuangxin , Tang Bin
Published: July 2024

Lung cancer is the leading cause of cancer-related death worldwide, especially non-small cell lung cancer. Early diagnosis and better treatment choices have already provided a more promising prognosis for cancer patients. In targeted therapy, antagonists target specific genes supporting cancer growth, proliferation and metastasis. With the incorporation of targeted therapies in routine cancer therapy, it is imperative that the array of toxicities associated with these agents must be well-recognized and managed, especially since these toxicities are distinct from those seen with conventional cytotoxic agents. Drug-related nephrotoxicity has attracted attention when initiating cancer therapy. Our review aims to summarize the adverse renal effects caused by targeted therapy during lung cancer treatment, mainly focusing on EGFR and ALK tyrosine kinase inhibitors. Also, we discuss the possible mechanism of the side effect and provide managements to help improve the renal function in clinical practice.
Single cell multi-omic analysis identifies key genes differentially expressed in innate lymphoid cells from COVID-19 patients
Authors: Kaushik Abhinav , Chang Iris , Han Xiaorui , He Ziyuan , Komlosi Zsolt I. , Ji Xuhuai , Cao Shu , Akdis Cezmi A. , Boyd Scott , Pulendran Bali , Maecker Holden T. , Davis Mark M. , Chinthrajah R. Sharon , DeKruyff Rosemarie H. , Nadeau Kari C.
Published: July 2024

Introduction

Innate lymphoid cells (ILCs) are enriched at mucosal surfaces where they respond rapidly to environmental stimuli and contribute to both tissue inflammation and healing.

Methods

To gain insight into the role of ILCs in the pathology and recovery from COVID-19 infection, we employed a multi-omics approach consisting of Abseq and targeted mRNA sequencing to respectively probe the surface marker expression, transcriptional profile and heterogeneity of ILCs in peripheral blood of patients with COVID-19 compared with healthy controls.

Results

We found that the frequency of ILC1 and ILC2 cells was significantly increased in COVID-19 patients. Moreover, all ILC subsets displayed a significantly higher frequency of CD69-expressing cells, indicating a heightened state of activation. ILC2s from COVID-19 patients had the highest number of significantly differentially expressed (DE) genes. The most notable genes DE in COVID-19 vs healthy participants included a) genes associated with responses to virus infections and b) genes that support ILC self-proliferation, activation and homeostasis. In addition, differential gene regulatory network analysis revealed ILC-specific regulons and their interactions driving the differential gene expression in each ILC.

Discussion

Overall, this study provides mechanistic insights into the characteristics of ILC subsets activated during COVID-19 infection.