bluuebunny/crossref_metadata_2025 huggingface dataset:
RtD-Net: Low-light image enhancement network based on deep learning
Authors: Wang Manli , Zhang Hang , Zhang Changsen
Published: July 2023

Existing low-light image enhancement techniques are mostly not only difficult to deal with both visual quality and computational efficiency but also are prone to detail loss and low contrast. in unknown complex scenarios. To solve these problems, we proposed an efficient low-light enhancement network for Removing the Darkness (denoted as RtD-Net). The network decomposes the image into two parts, the illumination branch is used to deal with light regulation and the reflection branch is used to deal with degradation removal. In this paper, we introduce the structure of RtD-Net, loss function, and training method of the model. First, the residual layer module is added to the network structure to improve the feature learning performance and the detail processing ability of the network; then a composite function including image reconstitution loss function, SSIM (Structural Similarity) loss function and TV loss function is used to optimize the contrast, brightness, color and saturation of the low-light image; Finally, segmental training is used to further improve the quality of the generated enhanced images. In the experimental comparison, the model demonstrates more advanced performance in both qualitative and quantitative comparisons, and is in an advantageous position when comparing with other low-light image enhancement models for image quality metrics. It can be proved through experiments that the proposed method has reached the state-of-the art in terms of processing speed and effect.
Probiotics and Diet Modifications: A Holistic Approach to Tackling Helicobacter pylori with the Help of the Gut Microbiota
Authors: Addissouky Tamer A. , Wang Yuliang , Sayed Ibrahim El Tantawy El , Khalil Ahmed A.
Published: July 2023

Background
Helicobacter pylori is a common gastrointestinal bacterium that can cause a range of diseases, including gastritis, peptic ulcer disease, and gastric cancer. The gut microbiota plays an important role in H. pylori colonization and associated diseases.
Main body:
Lifestyle factors, such as diet, stress, smoking, and alcohol consumption, can impact the gut microbiota composition and function, and may influence the risk of H. pylori colonization and H. pylori-associated diseases. Strategies to promote gut health, such as a healthy diet, stress reduction, smoking cessation, alcohol moderation, regular exercise, adequate sleep, antibiotic stewardship, and probiotic supplementation, may help to reduce the risk of H. pylori colonization and enhance the effectiveness of H. pylori eradication therapy. Furthermore, the gut microbiota may also be a potential target for H. pylori eradication, and personalized treatment approaches based on individual patient characteristics may be necessary to optimize H. pylori eradication rates and reduce the risk of adverse effects.
Conclusion
Further research is needed to better understand the role of the gut microbiota in H. pylori eradication and to develop more effective treatment strategies. By promoting gut health and developing personalized treatment approaches, we may be able to reduce the burden of H. pylori-associated diseases and improve patient outcomes.
An open-label single-center investigator-initiated exploratory clinical study in patients with refractory or recurrent solid tumors: ‘R-ISV-FOLactis’ trial
Authors: Dai Juanjuan , Wang Xiaolu , Chen Xinjie , Zhu Junmeng , Zhou Yingling , Min Limei , Qi Haoyue , Liu Qin , Shen Jie , Tian Manman , Shao Jie , Liu Baorui , Li Rutian
Published: July 2023

Background: As a breakthrough tool for cancer immunotherapy, the therapeutic cancer vaccine, which includes personalized neoantigen vaccine and in situ vaccine, is in rapid development. In situ vaccination can be realized by radiotherapy and intratumoral immune injection. Additionally, immune checkpoint inhibitor is a common treatment modality for tumors. This study proposes to combine intratumoral injection, radiotherapy, and PD-1 inhibitors for patients with recurrent or metastatic solid tumors and subsequently evaluate the efficacyand safety.
Methods/design: This exploratory clinical study is designed as an open-label, single-center trial aimed at treating patients with advanced solid tumors who are unresponsive or intolerable to standard treatment. Patients will be treated with hypofractionated radiotherapy, intratumoral injection of FOLactis, and PD-1 blockades. Additionally, 300mg cyclophosphamide will be added during intravenous administration of PD-1 blockades to inhibit regulatory T cells. Immune maintenance therapy with PD-1 blockades will be administered every three weeks until disease progression or the emergence of intolerable toxicity. The primary endpoint of this study is to observe the objective efficacy and safety of the combined regimen, with the secondary endpoint to evaluate abscopal effects and the correlation between the immunological rationale and efficacy.
Discussion: Both radiotherapy and intratumoral immune injection are approaches to conducting in situ vaccination. Their combination can enhance anti-tumor immunity by targeting multiple links of the cancer-immunity cycle. PD-1 blockade, a kind of immune checkpoint inhibitor, has garnered significant attention in tumor immunotherapy research in recent years. In this study, a triple combination of radiotherapy, intratumoral immune injection, and intravenous PD-1 inhibitor will be utilized to treat patients with advanced solid tumors to trigger antitumor immunity. The combined treatment is expected to be feasible and effective and provide a novel option for the comprehensive treatment of cancer.
Trial registration: ChiCTR. gov.cn: ChiCTR2200060660.
Sequencing methods to study the microbiome with antibiotic resistance genes in patients with pulmonary infections
Authors: Dong Tingyan , Wang Yongsi , Qi Chunxia , Fan Wentao , Xie Junting , Chen Haitao , Zhou Hao , Han Xiaodong , Wang Michael Xia
Published: July 2023

Background
Various antibiotic resistant bacteria are known to induce repeated pulmonary infections and increase morbidity and mortality. A thorough knowledge of the spectrum of bacteria with antibiotic resistance genes (ARGs) can improve the antibiotic treatment efficiency. In this study, we induced metagenomic next-generation sequencing (mNGS) alignment and assembly methods in the bioinformatics analysis pipeline to reveal the profile of bacteria with ARGs (ARB) in samples from patients with pulmonary infections.
Methods
A retrospective analysis of 151 clinical samples from 144 patients with pulmonary infections was undertaken by mNGS and conventional microbiological detection methods. Positive ARB were determined according to the analysis results detected both by the alignment and assembly methods. Co-occurrence analysis of ARG-ARB network was conducted to investigate the attributions between ARGs and microbial taxa. We also evaluated the potential application conditions to predict ARGs using those two approaches.
Results
Compared to that using conventional detection methods, the false-positive detection rate of ARB was significantly higher using mNGS alignment method. The assembly method could assist the determining of the detected pathogens by the alignment method as true ARB and improve the predictive capabilities (46% > 13%). ARG-ARB network revealed the main ARGs in predominant ARB. A total of 361 ARGs were detected, which mostly belonged to the multidrug class and β-lactam antibiotic classes. Specifically, 101 ARGs (existing in two approaches) and 34 ARGs (detected only by assembly method) achieved a clear ARG-bacteria attribution and potentially could optimize the reference antibiotic resistance database. The most prevalent ARB and its corresponding ARG and drug classes were as follows in this study: Acinetobacter baumannii (ADE, multidrug), Pseudomonas aeruginosa (MEX, multidrug), Klebsiella pneumoniae (MDT, aminocoumarin; EMR, fluoroquinolone), Stenotrophomonas maltophilia (SME, multidrug) and Corynebacterium striatum (carA, MLSB).
Conclusion
Collectively, our findings demonstrated the applicability of mNGS alignment and assembly as antibiotic resistant diagnostic methods and uncovered pulmonary infection-associated ARB and ARGs, potentially, as antibiotic treatment targets for the pulmonary infection.
Evaluation of Anogeissus Leiocarpus (African Brich) Leaves Extract and its Wood Ash for Dyeing and Mordanting of Cotton Fabric
Authors: Leulseged Sawiros , Worku Amare
Published: July 2023

Now a day the coloration of textile materials is done by using mainly synthetic dyes. This is because synthetic dyes have better quality than natural dyes. However, these dyes are not eco-friends, and nearly the modern world has returned to using natural dyes as eco-friend dyeing alternatives. Unfortunately, these natural dyes have some drawbacks that directly correlate with quality. This research aimed to bring a qualified eco friend alternative dyes and mordants from A.leiocarpus tree leaves and wood ash respectively for coloring the cotton fabric. To examine the quality of the natural mordant it’s necessary to compare with synthetics mordants which are accepted globally. Here in this study 5% of Al2SO4 and 1% of FeSO4 were used as controls for comparison and then dyeing with three different methods of mordanting, which are pre, simultaneous, and post, to obtain better results on the color fastness and color strength. The maximum K/S value, which is 4.389, and color fastness, except light fastness, was obtained from Al2SO4 pre-mordanting methods. The ash-mordanted one showed dull yellowish color with good uniformly dyeing with the 2.664 K/S maximum value at the time of pre-mordanting. The color fastness has given almost the same fastness value in both wash and rub but the ash-mordanted fabric shows better light fastness which is 6, in pre mordanting method.
Prenatal diagnosis and molecular cytogenetic analyses of a homozygous Robertsonian translocation family with novel mosaic Robertsonian fission karyotype
Authors: Wu Qian , Liu Ruixue , Yu Chunjiao , Wang Bo , Luo Lan
Published: July 2023

Background
Approximately one person in 1,000 is a Robertsonian translocation carrier. Errors in the formation of eggs (or more rarely of sperms) may be the cause of Robertsonian translocation. Most Robertsonian translocation carriers are healthy and have a normal lifespan, but do have an increased risk of offsprings with trisomies and pregnancy loss. The fitness of rob translocation carries is reduced, but rob translocation can provide material for evolution.
Methods
We have done prenatal diagnosis and molecular cytogenetic analyses on this homozygous Robertson translocation family. We report a homozygous Robertson translocation family with previously undescribed mosaic Robertsonian fission karyotype.
Results
We identified six Robertsonian translocation carriers in this family. Four were heterozygous translocation carriers of 45,XX or XY,der(14;15)(q10;q10), one was a homozygous translocation carrier of a 44,XY,der(14;15)(q10;q10),der(14;15)(q10;q10) and one was a previously undescribed Robertsonian fission carrier of 45,XN,der(14;15)(q10;q10)[42]/46,XN[58] with normal phenotype.
Conclusion
We reported a previously undescribed mosaic Robertsonian fission karyotype. The homozygosity of Robertsonian translocation for speciation may be a potential mechanism of speciation in Humans. In theory, the carriers of homologous Robertsonian translocation can't produce normal gametes, but Robertson fission made it possible for them to produce normal gametes.
Acid-responsive lipid-coated CaCO3/Cisplatin "Watermelon-shaped" nanoparticles combined with Bmi1 siRNA reverse HCC resistance by inhibiting cancer stem cells
Authors: Li Weijie , Wang Han , Meijing Li , Sun Yan , Zhong Lijie , Li Bin , Liu Yong , Wang Fei , Yang Tan
Published: July 2023

Cisplatin resistance is a major obstacle in the treatment of Hepatocellular carcinoma (HCC), characterized by reduced intracellular drug accumulation and altered DNA repair/apoptosis signaling. Current strategies targeting individual factors have limited efficacy in reversing cisplatin resistance. To address this challenge, we propose a novel drug delivery system utilizing watermelon-shaped nanoparticles composed of a cisplatin core evenly distributed within a CaCO3 shell. These nanoparticles are subsequently coated with positively charged phospholipids, facilitating the absorption of Bmi1 siRNA (LCa/C@B) with the ability to inhibit HCC cancer stem cells (CSCs). In vitro and in vivo experiments demonstrate the effective release of Bmi1 siRNA and cisplatin in the slightly acidic tumor microenvironment, resulting in their uptake by drug-resistant tumor cells. LCa/C@B exhibits a synergistic effect in inhibiting CSCs, effectively reversing cisplatin chemotherapy resistance, and improving the therapeutic outcomes in HCC-resistant cells and an HCC primary mouse model. This hybrid drug delivery system, combining calcium carbonate and cisplatin with Bmi1 siRNA, presents a promising approach for overcoming chemotherapy resistance in HCC.
Sensorimotor adaptation in Virtual Reality: Do instructions and body representation influence aftereffects?
Authors: Wähnert Svetlana , Schäfer Ulrike
Published: July 2023

Perturbations in virtual reality (VR) lead to sensorimotor adaptation during exposure, but also to aftereffects once the perturbation is no longer present. An experiment was conducted to investigate the impact of instruction and body representation on the magnitude and the persistence of these aftereffects. Participants completed the paradigm of sensorimotor adaptation in VR. They were assigned to one of three groups: control group, misinformation group or arrow group. The misinformation group and the arrow group were each compared to the control group to examine the effects of instruction and body representation. The misinformation group was given the incorrect instruction that in addition to the perturbation, a random error component was also built into the movement. The arrow group was presented a virtual arrow instead of a virtual hand. It was hypothesised that both would lead to a lower magnitude and persistence of the aftereffect because the object identity between hand and virtual representation would be reduced and errors would be more strongly attributed to external causes. Misinformation led to lower persistence, while the arrow group showed no significant differences compared to the control group. The results suggest that information about the accuracy of the VR system can influence the aftereffects, which should be taken into account when developing VR instructions. No effects of body representation were found, and the reasons for this were discussed.
Maximal subextension and approximation of m- subharmonic function
Authors: Phu Nguyen Van , Dieu Nguyen Quang
Published: July 2023

In this paper, we first study subextensions in the classes Fm(Ω) and εm,χ(Ω). These results are then used to study approximation in the classes Fm(Ω) and εm,χ(Ω).
2010 Mathematics Subject Classification: 32U05, 32W20.
First systematic review and meta-analysis of the risk magnitude of climate-change effects on child health
Authors: Weeda Lewis , Bradshaw Corey , Judge Melinda , Saraswati Chitra , Souëf Peter Le
Published: July 2023

Children are significantly more vulnerable than adults to climate-related health threats, but studies examining how climate change affects human health have been mainly descriptive and lack an assessment of the magnitude of health effects children face. In this systematic review and meta-analysis, we searched online databasesPubMed,Medline,Embase, andWeb of Sciencefor observational studies published up to 5 January 2023 following PRISMA guidelines. We included studies if they explored climate variables/events and measured a quantifiable child-health outcome. We extracted data from published reports for a meta-analysis where we standardised effect sizes and compared them among different groupings of climate variables and health outcomes. We evaluated each study individually and aggregated and analysed relevant qualitative and quantitative data. We identified 1301 articles from the four large databases in our systematic literature review, of which 163 studies were eligible for analysis. We identified many relationships between climate change and child health, the strongest of which were increasing risk (60% on average) of preterm birth from exposure to temperature extremes. Respiratory disease, mortality, and morbidity were also influenced by climate changes, but to a lesser extent than preterm birth. The effects of different pollutants on health outcomes were considerably smaller compared to temperature effects, but with most (16/20 = 80%) pollutant studies indicating at least a weak effect. Most studies occurred in high-income regions, but we found no geographical clustering according to health outcome, climate variable, or magnitude of risk. We identified the following protective factors for climate-related child-health threats: (i) economic stability and strength, (ii) access to quality healthcare, (iii) adequate infrastructure, and (iv) food security. Threats to these services vary by local geographical, climate, and socio-economic conditions. Children will have increased prevalence and severity of disease due to anthropogenic climate change, and our quantification of the magnitude of expected increases is essential to plan for mitigation that will improve the health of current and future generations.
Sex-differences in adverse symptoms reported as side-effects by Parkinson´s disease patients receiving Deep brain stimulation (DBS) in the subthalamic nucleus
Authors: Prasad Asheeta A. , Serra Gian Pietro , Werner Lucas , Wallén-Mackenzie Åsa
Published: July 2023

Parkinson’s disease (PD) is a neurodegenerative disorder affecting several aspects of motor and non-motor function. Currently, no cure exists for PD. Instead, existing treatments aim to alleviate symptoms. In advanced-stage PD, Deep Brain Stimulation (DBS) is applied to relieve motor symptoms. The subthalamic nucleus (STN) is a common target area for implantation of DBS leads. While STN-DBS efficiently relieves PD motor symptoms, there have been reports of adverse side-effects. Sex-differences have been reported in a range of factors correlated with PD. However, sex-differences in patients’ experience of side-effects upon STN-DBS remain to fully uncover.
This study collated reports on adverse symptoms reported as side-effects upon STN-DBS and examined their sex distribution; biological male vs biological female. Overall, most studies had a disproportion of males to females, or did not report sex at all. 17 original articles detailing side-effects reported by PD patients upon STN-DBS, while also providing information of reporting patients´ sex, were identified and analysed. Adverse side-effects were separated into three main categories (physiological, affective, cognitive). Articles included single case reports and larger clinical cohorts to cover the range STN-DBS related symptoms. Both males and females experienced physiological side-effects, both motor and autonomic. Males reported more gait and balance side-effects while dyskinesia was reported by both males and females. Most prominent sex-difference was detected in the affective and cognitive categories. Depression was the main affective side-effect reported by females. Males, but not females, reported aggressive behavior and sexual dysfunction upon STN-DBS. An additional observation across studies was that side-effects experienced by females were less detailed.
This review of published clinical reports revealed sex-differences in adverse side-effects of STN-DBS described by PD patients and also detected sex-differences in the descriptive details of reported side-effects. These findings advocate for sex-inclusion and streamlining of data to equalize information from both sexes when reporting beneficial and adverse effects of this treatment. With lack of equal level of description across sexes, progress in treatment is hampered. Further knowledge of sex-differences will support tailor-designed treatments for improved efficacy in PD patients of both sexes undergoing, and living with, STN-DBS treatment.
Estimating the Gravitational Redshift in Galaxy Clusters and Voids Using Hernquist and Tophat Density Profiles
Authors: Wamalwa Dismas Simiyu
Published: July 2023

Cosmic voids happen to occupy most under dense regions of the universe. They can, therefore, be used to test our theories of structure formation and cosmology. By assuming a density profile and using it to obtain the gravitational potential, the gravitational redshift is computed. The effect is compared in two profiles of clusters and voids. From the computations, the gravitational redshift in clusters is higher than that in voids, implying that if the effect is to be considered in voids, a larger survey is required. The radii used are 20Mpc and 1Mpc for voids and clusters respectively.
Observation and model simulation of aerosol optical properties and size distribution over the hilly terrain of Northeast India
Authors: Barman Nilamoni , Kundu Shyam S , Borgohain Arup
Published: July 2023

The aerosol optical properties are studied at northeast India's high-altitude station. The aerosol total scattering at the station is influenced by the mountain valley wind circulation. The backward trajectory shows the pre-monsoon season is a transition period when the air mass transportation alters the direction from northwest to south direction. The dominance of biomass burning and other emissions over long-range transportation of particles contributed strongly to the aerosol loading, which caused the higher range of scattering Ångström exponent (α450−700 nm > 1.5) in the pre-monsoon, monsoon, and post-monsoon seasons. The α450−700 nm varies from 1.47 to 1.88, indicating that the fine aerosol particles with a radius of < 0.5 µm have dominance at the station. To estimate the backscatter fraction (bf) and Asymmetry Parameter (g), theoretical approximation (Sviridenkov 2017 and Kokhanovsky 2006) and model simulation (MieTab and Mieplot) are utilized. The bf and g are found to be in the range of 0.11–0.13 and 0.68 to 0.74, after comparison of this value with the model simulated particle size, observed that the radius varies from \(\approx\) 0.17 µm − 0.21 µm. The bf decreased from winter to monsoon season, while the g values enhanced, demonstrating a negative correlation. The bf value decreased owing to the less backscatter and higher forward scatter for bigger particles from winter to monsoon. Thus, the g values were smaller for higher bf values and associated with smaller aerosol particles and vice-versa.
The Mediating Role of Firm Prestige in the Relationship between Perceived Quality and Behaviour Intention in Customer Cafeteria Experiences
Authors: Samsa Caglar
Published: July 2023

Customer experience is viewed from different perspectives as an economic, marketing, management, and competitive strategy. Regardless of the perspective, customer experience is a business strategy and a critical concept that plays a key role in firm success in the 21st century. In recent years, there has been an increasing focus on customer experience as a way for companies to differentiate themselves and build strong relationships with their customers. This approach is based on the idea that companies can build emotional bonds with their customers by providing memorable and positive experiences, leading to greater loyalty, repeat business and positive word-of-mouth. To create these experiences, companies adopt a customer-centric approach that involves understanding their customers’ needs, preferences and behaviours and using this information to design and deliver experiences that exceed their expectations. This approach requires moving away from traditional product-centric or sales-oriented strategies and instead places the customer at the centre of the company’s operations and decision-making processes. From a customer-centric perspective, meeting customer expectations in customer experiences is very important in shaping customer perceptions, attitudes and behaviours. From an experience-based perspective, a study was designed by taking into account the expectancy-affirmation theory, which is a psychological model that explains how customers evaluate their satisfaction with a product or service based on their expectations and perceptions of the experience, and a psychological theory that predicts that meeting customers’ expectations from their experiences may lead to a change in customer behaviour. The study examined the mediating role of firm prestige in the relationship between the perceived quality of customer experiences and customer behaviour intention. For this purpose, data were collected from 230 participants who had cafeteria experience through a questionnaire. The collected data were increased to 5000 by bootstrapping (derivative sampling) through the PLS-SEM algorithm. The study found that store prestige partially mediated the relationship between perceived experience quality and behavioural intention (customer satisfaction/loyalty) but did not mediate the relationship between food quality and behavioural intention (customer satisfaction/loyalty). The study also found that store prestige mediated the relationship between atmosphere quality and service quality, and behavioural intention (customer satisfaction/loyalty). Subsequently, cafeteria management policies should prioritise atmosphere and service quality. These factors directly impact the store’s prestige, leading to customer satisfaction and loyalty.
Corporate Social Responsibility of Companies in the Context of Russian Military Aggression in Ukraine
Authors: Reshetnikova Iryna , Sanak-Kosmowska Katarzyna
Published: July 2023

The war in Ukraine became a test for many foreign companies from the point of view of implementing the principles of corporate social responsibility, which they had previously declared. This especially affected international businesses, including Polish companies, that actively worked on the Russian and Ukrainian markets, whose economic interests for many years related to cooperation with Russian partners and the sale of Russian goods on the market of Ukraine. This article is devoted to the issue of corporate social responsibility of businesses in the context of Russian military aggression in Ukraine. The main objective of the presented paper was to identify and clarify the role of corporate social responsibility and business attitudes towards corporate social responsibility and its impact on decisions on possible cooperation in times of war. In addition, the specific objective was to identify the effects of Russia’s aggression against Ukraine on business activities conducted by Polish entrepreneurs, considering their attitudes towards corporate social responsibility principles. This goal was achieved through an analysis of the literature on the subject and in-depth interviews conducted with a sample of 100 Polish entrepreneurs. The results indicated that Polish entrepreneurs felt significant negative consequences of the conflict. After Russia’s aggression against Ukraine, most surveyed companies suspended (47,1%) or ended cooperation (43.1%) with Russian partners or exported products to Russia. Contrary to expectations, only some companies (18.4%) cited corporate social responsibility values among the reasons for this decision. It was also shown that there was no relationship between corporate social responsibility involvement and the declared ratings of companies remaining in Russia. In addition, companies reporting to suspend their activities during the conflict are considering a return to earlier cooperation in the future.
Span and stably trivial bundles
Authors: Varadarajan Kalathoor
Published: July 2023

E. Thomas introduced the notion of span of a differentiable manifold (or of a vector bundle). The notion of span can be extended in an obvious way to $PL$-microbundles, topological microbundles and spherical fibrations. In the case of a vector bundle or a microbundle the dimension of the fibre will be referred to as its rank. A spherical fibration with fibre homotopically equivalent to $S^{k-1}$ will be said to be of rank $k$. In this paper we study stably trivial objects of rank $k$ over a $CW$-complex of dimension $\leqq k$ from each of the above collections. Then we determine the span of such stably trivial objects over $CW$-complexes of a ``special type'' yielding generalizations of the Bredon-Kosinski, Thomas theorem on the span of a closed differentiable $\pi$-manifold [3], [19]. Though originally $PL$-microbundles were defined only over simplicial complexes, in this paper by a $PL$-microbundle of rank $k$ over a $CW$-complex $X$ we mean an element of the set $[X,BPL(k)]$ of homotopy classes of maps of $X$ into $BPL(k)$.
Developing a unit testing framework for control system software implementation of a degassing vacuum pumping station
Authors: Abdrakhmanov Marat I.
Published: July 2023

Research objective is to develop a test automation system for the process algorithm software implementation of the degassing vacuum pumping station control system operation at a coal mine. Relevance. The vacuum pumping station is an essential component of a mine degassing system. Degassing system operation depends on its correct functioning. A programmable logic controller with appropriate software is a key component of the vacuum pumping station automation system. Correct software implementation of the system operation process algorithm is of primary importance. To verify the compliance of the implementation with the requirements, manual testing is commonly used according to a pre-compiled test-plan, which is formed based on the requirements imposed on the system. Manual testing has a number of disadvantages. It is a long process where human errors are likely to occur, and the use of a test bench and/or an assembled control system sample is inevitable. Requirements for the algorithm can be changed in the course of program development, debugging, and initiation, which greatly complicates the testing process. Results. To solve the problem of process algorithm software implementation testing automation, the process control algorithm should be isolated from the software components responsible for the hardware. Access to the process control algorithm should be provided through standard interfaces (for example, OPC UA). Additional process equipment (valves, etc.) used in the automation system should be implemented in the form of emulators with an opportunity to assign their modes of operation. By creating an additional software layer of interaction with a process algorithm and emulator in a programming language with advanced test tools (for example, Python), it is possible to implement test scenarios from a test plan in this language. It will allow testing in automatic mode rather than manually. Conclusions. The proposed approach to process algorithm software implementation testing automation will greatly simplify software development for this type of automation and control systems
Frost-resistant emulsion explosives
Authors: Gorinov Victor
Published: July 2023

Introduction. The paper considers the development of a frost-resistant emulsion explosive (EE) to create cartridges, including the ones with a small diameter. Research objective is to develop a frost-resistant cap-sensitive EE to create cartridges, including the ones with a small diameter, to increase the reliability, effi ciency, and safety of blasting operations in the northern and Arctic regions. Methods of research are based on EE frost resistance theoretical analysis and laboratory study, as well as ground tests on detonation velocity and completeness in the developed EE. Results. It is shown that EE with an oxidizing phase based on a binary solution of ammonium and calcium nitrate with calcium chloride under a particular water content and with a fuel phase based on the DEP-1 emulsifi er solution in a wide range of petroleum products meets the requirements of frost resistance. The resulting EE in a practically relevant temperature range (–60…+40 °С) represents an elastoplastic body that makes it possible to form durable cartridges that retain geometry. The socket for the detonator capsule is easily made anywhere in the cartridge using aluminum piercel or drill of the wood twist drill type. EE reliably detonates from the detonator capsule of the non-electric detonation system (SINV). The detonation velocity in open cartridges 32 mm in diameter is 4700–5000 m/s. Conclusions. The results obtained in the article justify the development of EE compositions suitable for patronized explosives for the northern and Arctic regions.
Tecnologias leves na prevenção de doenças e promoção da saúde
Authors: Castro Marta Rocha de
Published: July 2023

A medicina moderna, baseada em tecnologias duras é focada na biologia e nas doenças, sendo muitas vezes pouco eficiente para o campo da prevenção, além de não carregar uma abordagem acolhedora para o doente. As medicinas tradicionais fazem uso de tecnologias leves para avaliarem as pessoas e carregam uma abordagem integrativa e acolhedora, tendo forte potencial para a prevenção de doenças e baixo custo financeiro, muitas vezes são a única alternativa de cuidado para populações sem acesso aos serviços médicos. A semiologia da face é utilizada como uma forma de avaliação diagnóstica em algumas medicinas tradicionais, incluindo a Medicina Tradicional Chinesa. Através de algumas características na face podemos analisar desequilíbrios energéticos antes mesmo de surgirem sintomas possibilitando uma intervenção preventiva através de mudanças de hábitos, acupuntura, atividades físicas, alimentação e uso de ervas, evitando assim o adoecimento. No ano de 2016 fiz uma pesquisa de mestrado sobre a avaliação facial na Medicina Tradicional Chinesa, pelo programa EICOS, UFRJ e vou trazer um dos estudos de caso com uma participante para ilustrar o texto e contribuir com a discussão sobre a importância de tecnologias leves no campo de prevenção de doenças.
Subutilização, limites e potencialidades do Sistema de Informação em Saúde para a Atenção Básica (SISAB)
Authors: Oliveira Junior Joao Geraldo de
Published: July 2023

Este estudo teve como objetivo identificar na produção científica as ações de utilização das informações do Sistema de Informação em Saúde para a Atenção Básica (SISAB). A pesquisa parte do pressuposto que o SISAB tem o potencial para apoiar os gestores no planejamento em saúde e na tomada de decisão, superando o fato de ser apenas um sistema de monitoramento do repasse financeiro. Para o alcance do objetivo foi realizado uma revisão integrativa de literatura e para auxiliar a etapa de análise do material foram elaborados dois quadros sinópticos. Durante a revisão, notou-se uma lacuna na literatura com a ausência de evidências que avaliassem o impacto do SISAB, a confiabilidade dos seus dados e até mesmo do seu uso como uma ferramenta de monitoramento e avaliação das políticas e programas da AB. Grande parte do conhecimento científico produzido estava relacionado ao uso do SISAB para fins de monitoramento do financiamento das equipes. Os estudos ainda apontaram que a informatização e a qualificação dos usuários do sistema são fundamentais para a adoção do SISAB como ferramenta gerencial. Recomendou-se a instituição no país de uma política de avaliação sistemática dos dados para aumentar a confiabilidade dessa aplicação. Este estudo apresenta respostas para melhorar a implantação dos sistemas da estratégia e-SUS AB. Por fim, os achados revelam que investimentos robustos em informatização, capacitação e integração com outros sistemas podem reduzir o retrabalho dos usuários que utilizam essas tecnologias e transformar a estratégia e-SUS AB.
Incidência e fatores de risco associados à depressão pós-parto em um hospital universitário do Sul do Brasil
Authors: Machado Julia Pinheiro , Botelho Lucio José , Arce Iskenderian Hugo Alejandro , Martins da Silva Amanda
Published: July 2023

A Depressão Pós-Parto (DPP) é uma condição clínica sub diagnosticada no puerpério, porém com grande impacto na saúde pública. O artigo tem como objetivo identificar a incidência de DPP e os fatores de risco associados nas mulheres cujo parto foi realizado no Hospital Universitário de Florianópolis, e descrever seu perfil socioeconômico. Trata-se de um estudo de corte. Foram usados dois parâmetros, um socioeconômico, psicossocial e obstétrico, e a Escala de Depressão Pós-Natal de Edimburgo (EPDS) nas 48 horas pós-parto. O último foi replicado seis semanas após. Foi interpretado como provável DPP escore na EPDS ≥ 11. Foram utilizados os testes de Qui-quadrado para associação entre variáveis selecionadas como possíveis fatores de risco para DPP. A análise epidemiológica foi realizada a partir dos riscos absolutos e relativos. Resultados: 148 mulheres foram incluídas no estudo. A incidência de DPP nas 48 horas após o parto foi de 22,97%, e seis semanas após correspondeu a 31,5% da amostra.  Os fatores de risco encontrados em ambos os momentos foram: diagnóstico prévio de transtorno psiquiátrico; hiperêmese gravídica na última gestação e relação perturbada com o cônjuge. Os fatores de proteção comuns incluíram satisfação com o corpo e com a notícia da gravidez. O escore ≥ 11 na EPDS no pós-parto imediato foi associado como fator de risco para o desenvolvimento de DPP seis semanas após e para o risco de causar dano a si mesma. Conclui-se que a incidência elevada de DPP está relacionada com história pregressa e fatores sociais, demonstrando a importância da investigação precoce no período perinatal, para prevenção e tratamento adequado da mesma.
Acesso e uso da informação do repositório datasus para a construção do perfil epidemiológico de sífilis congênita no estado da Paraíba
Authors: Bárbara Lopes  , Talita Laís Medeiros Domingos  , De Souza e Silva Pollianna Marys , Monalisa Alexandre Honorato
Published: July 2023

A transmissão vertical da sífilis consiste em um grande problema de saúde pública no Brasil e a conscientização da prevenção e tratamento é necessária para enfrentamento do problema. Esse estudo teve como objetivo utilizar informações do repositório DATASUS para a construção do perfil epidemiolófico de sífilis congênita no estado da Paraíba.Trata-se de um estudo epidemiológico, descritivo e retrospectivo, de caráter quali-quantitativo, realizado através do repositório institucional Datasus, no período de setembro de 2021. A coleta de dados foi realizada com os dados contidos no Datasus sobre os casos de SC no período dos anos de 2014 a 2018. Foram notificados 1428 casos, localizados principalmente na 1º região de saúde da Paraíba destes, observou-se que a maioria dos casos de SC em crianças é do sexo feminino com a porcentagem de 47,48% do total de casos. O maior percentual de detecção de SC foi até 6 dias de nascido, referente a 96,92% dos casos no estado da Paraíba. A maior parte das mães portadoras possuía da 5ª à 8ª série incompleta (20,7%) e que, em 27,6% dos casos, essa informação foi classificada como ignorada. Desta forma, é indispensável o desempenho dos profissionais de saúde para detectar, intervir e prevenir a Sífilis no decorrer da gestação, favorecendo a redução da incidência dessa patologia. Sendo assim, o período pré-natal se torna essencial a ação de medidas preventivas de saúde que possibilite uma gestação sem intercorrências.
Cell Physiological Behavior in the Context of Local Hypothermia
Authors: Abdullah Marzoog Basheer
Published: July 2023

Local hypothermia has protective effects on injured endothelial cells, cardiomyocytes, and neurocytes. Unfortunately, the underlying mechanism of local hypothermia is still unknown. The overall effect of local hypothermia involves changes in cellular and extracellular homeostasis. Reduction in cellular metabolism is the hallmark effect of local hypothermia, resulting in a reduction in energy expenditure already impaired by starvation conditions, such as ischemia. However, on a molecular basis, local hypothermia modifies cell physiology according to the type and the vitality of the cells (brain cells are more important than skin cells; therefore, local hypothermia of the brain tissue is more critical than skin tissue, and the overall reaction of the organism is to prevent the brain from dying). This involves activating survival mechanisms, such as autophagy of brain tissue and apoptosis. The activated signaling pathways are not identical in various tissues. However, the whole machinery signaling axes have not yet been elucidated. Local hypothermia promotes the healing of the injury and improves the proliferation of regenerative tissue, but not differentiation. Hypothermia prevents the transdifferentiation of endothelial cells, neurons, and myocardiocytes. Finally, the therapeutic effects of hypothermia involve activating the nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).
The Study of Risk Factors and The Predict Model of Cerebral Microbleeds
Authors: Lv Tao , Li Changqing
Published: July 2023

Background:

To determine the association of cardiovascular risk factors with the presence
and anatomic location of CMBs and construct a factor-based evaluating model to predict a
high CMBs burden.

Methods:

We assessed the relation of age, male, various cardiovascular risk factors, medication
use, stroke histories and white matter hyperintensities (WMH) to the presence and location of
CMBs with univariate analysis and multiple logistic regression. Finally, we added risk factors for a
high CMBs burden to a factor-based evaluating model score.

Results:

485 patients were included in our study. CMBs were more prevalent with advanced age,
male sex, more cardiovascular risk factors and WMH. Alcohol use, hemorrhagic stroke history and
the degree of deep white matter hyperintensity (DWMH) were independent predictors for a high
CMBs burden (≥10). We finally structured a prediction model-HPSAD3 that consisted of hypertension,
alcohol use, hemorrhagic stroke history and WMH to predict a high CMBs burden. The
model-HPSAD3 has a higher positive predict value (77.08%) and negative predict value (75.89%)
to predict a high CMBs burden when the cut-off score is 4.

Conclusions:

Hypertension, alcohol use, hemorrhagic stroke history and WMH were added into
the model- HPSAD3, and there was a higher possibility of patients with CMBs ≥10 when the score
of HPSAD3 ≥4.
Silymarin Improves Thyroid Function in Lithium-treated Bipolar
Patients: A Randomized, Double-blind, Placebo-controlled Pilot Study
Authors: Ataei Sara , Mahdian Mohammad Reza , Ghaleiha Ali , Matinnia Nasrin , Nili-Ahmadabadi Amir
Published: July 2023

Background:

Thyroid dysfunction is one of the most important side effects of lithium carbonate.
Silymarin is a flavonolignan extracted from the milk thistle Silybum marianum (L.), which has
remarkable antioxidant and therapeutic properties. This clinical trial study aimed to evaluate the effect
of silymarin on thyroid function and serum antioxidant status in patients with lithium-treated bipolar
disorder.

Methods:

Bipolar patients with a depression episode and a history of at least six months of lithium use
were randomly divided into placebo-control (n=18) and intervention (n=19) groups. In addition to
standard medication, patients in the intervention and control groups received silymarin (140 mg) and
placebo tablets daily for ten weeks, respectively. Finally, thyroid function and serum antioxidant status
were evaluated along with clinical signs at the beginning and the tenth week.

Results:

Following the administration of silymarin, a significant increase was observed in total antioxidant
capacity (p = 0.004) and total thiol molecules (p = 0.005) levels in serum compared to the placebo
group. Although silymarin had no significant effect on serum triiodothyronine (T3) and lithium
levels, it could significantly improve the secretory status of thyroid-stimulating hormone (TSH; p =
0.002) and Thyroxine (T4; p = 0.02) hormones in comparison to the placebo group.

Conclusion:

The current study showed that silymarin might be effective for thyroid function in lithium-
treated bipolar patients by improving body’s antioxidant status.

Trial Registration Number:

IRCT20190811044513N2
UAV Remote Sensing Technology: A Review of Chinese Agricultural
Patents
Authors: Bao Yudong , Huang Yongqi , Liu Yuying
Published: July 2023

Background:

With the progress of science and technology and the advent of the new era, UAV remote sensing technology has developed rapidly in recent years and the application fields have been increasing. UAV remote sensing technology is widely used in the field of agriculture, crop growth monitoring, crop yield prediction, crop information monitoring, pest and disease detection and other aspects are more prominent.

Objective:

By analyzing and discussing the existing Chinese patents on UAV remote sensing technology, we summarize the current applications and future development prospects of UAV remote sensing technology in China's agricultural field.

Methods:

An overview of current Chinese patents on different directions of UAV remote sensing technology in the agricultural field, and an analysis of the methods used to achieve different application implementation effects.

Results:

By analyzing the existing Chinese patents on UAV remote sensing technology, we conclude that the functions they can achieve for different crops can be applied to the data collection of all crops, and analyze their characteristics to summarize future development trends.

Conclusion:

Through an in-depth study of Chinese UAV remote sensing patents in agriculture, it can be concluded that UAV remote sensing technology can achieve higher applicability and lower cost in agriculture, and for its information collection for one crop, it can be extended to apply to all crops. In the future, UAV remote sensing technology can be more easily and quickly applied to crop information acquisition in the agricultural field.
Medicinal Importance and Therapeutic Benefit of Bioactive Flavonoid Eriocitrin: An Update on Pharmacological Activity and Analytical Aspects
Authors: Patel Kanika , Patel Dinesh Kumar
Published: July 2023

Background:

Polyphenols are micronutrients and an important class of secondary metabolites that are naturally present in various types of plants and their derived byproducts. Humans obtain polyphenols and phytochemicals from different vegetables, fruits, spices, and teas. More than 8,000 different types of polyphenols have been isolated from different natural sources. Polyphenols play an important role in the plants’ resistance against pests and diseases. Plants from citrus class contain flavonoids, carotenoids, and ascorbic acid. Eriocitrin is a flavanone glycoside present in lemon juice and other citrus plants.

Methods:

Scientific research data on eriocitrin have been collected from Google, Google Scholar, Pub- Med, and Scopus databases, and analyzed in the present paper to determine the biological importance of eriocitrin in medicine. The medicinal importance and therapeutic benefit of eriocitrin in medicine have been investigated through literature data analysis of various research works. Pharmacological activity data have been thoroughly collected in the present work and analyzed in order to assess the health-beneficial aspects of eriocitrin against human disorders.

Results:

Scientific database analysis has revealed the medicinal importance and therapeutic benefit of eriocitrin in medicine. Scientific data analysis has revealed the anti-inflammatory, anti-nociceptive, and anti-obesity activities of eriocitrin. Further scientific data analysis has revealed the biological effect of eriocitrin on osteoarthritis, hepatocellular carcinoma, oral carcinogenesis, hepatic steatosis, oxidative damage, and different types of enzymes. In addition, eriocitrin has also been reported to exert potent antioxidant and suppressive effects on oxidative stress. Scientific data analysis has also revealed the significance of analytical techniques for the separation, isolation, and identification of eriocitrin.

Conclusion:

The present work indicates the biological importance of eriocitrin in medicine and other allied health sectors.