bluuebunny/crossref_metadata_2025 huggingface dataset:
Hearing loss and depressive symptoms in older Chinese: whether social isolation plays a role
Authors: Huang Hao , Wang Jiao , Jiang Chao Qiang , Zhu Feng , Jin Ya Li , Zhu Tong , Xu Lin , Zhang WS
Published: May 2022

Background: Existing evidence links hearing loss to depressive symptoms, with the extent of association and underlying mechanisms remaining inconclusive. We conducted a cross-sectional study to examine the association of hearing loss with depressive symptoms and explored whether social isolation mediated the association.Methods: 8,962 participants from Guangzhou Biobank Cohort Study were included. Data on self-reported hearing status, the 15-item Geriatric Depression Scale (GDS-15), social isolation and potential confounders were collected by face-to-face interview.Results: The mean (standard deviation) age of participants was 60.2 (7.8) years. The prevalence of poor and fair hearing was 6.8% and 60.8%, respectively. After adjusting for age, sex, household income, education, occupation, smoking, alcohol use, self-rated health, comorbidities, compared with participants who had normal hearing, those with poor hearing (β=0.74, 95% confidence interval (CI) 0.54, 0.94) and fair hearing (β=0.59, 95% CI 0.48, 0.69) had higher scores of GDS-15. After similar adjustment, those with poor hearing (odds ratio (OR)=2.13, 95% CI 1.65, 2.74) or fair hearing (OR=1.68, 95% CI 1.43, 1.99) also showed higher odds of depressive symptoms. The association of poor and fair hearing with depressive symptoms attenuated slightly but not substantially after additionally adjusting for social isolation. In the mediation analysis, the adjusted proportion of the association mediated through social isolation was 9% (95% CI: 6%, 22%).Conclusion: Poor hearing was associated with a higher risk of depressive symptoms, which was only partly mediated by social isolation. Further investigation of the underlying mechanisms is warranted.
Car Black Box using Raspberry Pi
Authors: Deshmukh Shreya
Published: May 2022

Nowadays, people are facing one of the most and biggest problems which is an accident. Most people are dying because of accidents. The death rate or even the smallest accident rate is increasing day by day. Traveling is an important part of life, whether it is a workplace or any other. The main reason for death recorded is due to the lack of unavailability of medical services at the accident. Another cause that i personally think is the lack of co-operation of people to follow signals. Practically thinking one cannot prevent or stop any kind of accident but can lower the post-trauma. In present days we can see that every single person may come across with accidents and this is one of the critical situations. Few people can survive and few people may lose their lives, which occurs due to lack of information. To overcome these problems, a black box came into existence. The main objective of the car black box using raspberry pi is to develop a hardware system that will monitor image and video, motion detection, humidity & temperature in real-time continuously on an SD card. So any input can be logged into memory so that any authenticated person can observe the specific data from any place (here from the same place too. The data is stored in the SD card that is externally connected to the Raspberry pi. The information is collected by Raspberry Pi processors using a camera module and other sensors which are connected to the raspberry pi which is Linux based operating system that will give all the collected data information to the monitoring system. The monitoring system will display the data (if needed and wanted) in real-time which helps the investigation to find out the scenario of the accident that occurred.
Application of finite element Analysis in dynamic changes of Spinal Mechanics in Osteoporotic Lumbar fracture
Authors: Yan Jianwen , Liao Zhong , Yu Yafang
Published: May 2022

Aim: To explore the effect of finite element biomechanical properties of different methods in the treatment of osteoporotic thoracolumbar fractures.Methods: Based on the ultra-thin CT scan data of a volunteer's thoracolumbar spine, the finite element method was used to simulate the treatment of osteoporotic thoracolumbar fracture. The images of thoracolumbar region were obtained by spiral CT scanning, and the three-dimensional geometric model was obtained by importing Mimics software, the finite element model of normal T11 ~ L2 segment was established by finite element software Abaqus, and the validity of the model loading was verified. Based on the finite element model of T11 vertebral compression fracture based on normal raw data, the clinical overextension reduction manipulation was simulated by different treatment methods, and the changes of stress and displacement in different parts of injured vertebrae were analyzed.Results: In this study, an effective finite element model of T11-L2 segment is established. The maximum stress, axial compression strength, axial compression stiffness (EF) and transverse shear stiffness (GF) of PKP and PVP treatment group were significantly better than those of conservative treatment group and open treatment group, and the difference was statistically significant. There was no significant difference between open treatment group and conservative treatment group, and there was no significant difference between PKP and PVP treatment group.Conclusion: The results of finite element analysis show that PKP and PVP in the treatment of osteoporotic thoracolumbar fractures can effectively improve the condition of patients, relieve their clinical symptoms, have a good prognosis and have a good long-term effect, and its biomechanical properties are good, the application effect is remarkable.
Immunoinformatics and structural vaccinology approach to design a Multi-Epitope Subunit Vaccine against Francisella tularensis through In Silico modeling
Authors: Hayat Chandni , Sikandar Haris , Shahab Muhammad , Liang Chaoqun , Duan Xiuyuan , Zheng Guojun , Junaid Muhammad
Published: May 2022

BackgroundFrancisella tularensis is a category A pathogen with the maximum infectious and death rates, demanding the development of a vaccine. In the last eight years, growing interest in F. tularensis has resulted in the generation of data about the pathogen and its host binding method. So far, extensive information is available, but there is no authorized vaccination on the market.MethodUsing in silico techniques, present study design to develop multi-epitope vaccine. From F. tularensis, B-cell and T-cell epitopes were predicted to design a vaccine. The selection of epitope was selected on basis of lower percentile score, antigenicity, Non-toxicity, and immunogenicity scores. The 193 amino-acid long vaccine construct was obtained by joining the epitopes through EAAAK, CPGPG and AAY Linkers.ResultOur vaccine represented overall the good stability, expression, immunostimulatory capabilities and solubility. Moreover, molecular docking and MD simulation exhibited strong interaction and stability of polypeptide vaccine construct. Conclusion:Design vaccine was verified as efficient in different computer-based immune response investigations and population coverage was good. But designed vaccines require scientific consensus and require in vitro experimental work also.
Comparing the effect of modified ureterosigmoidostomy（MainzⅡ）in the treatment of bladder cancer after open and laparoscopic radical cystectomy
Authors: Zhang Bin , He Yang , Zheng Duo , Liu Junyao , Qi Peng , Han Dali , yue Zhongjin , Shang Panfeng
Published: May 2022

Background
To analyze perioperative conditions and long-term efficacy of open modified ureterosigmoidostomy urinary diversion (OMUUD) in patients with bladder cancer who underwent open radical cystectomy (ORC) or laparoscopic radical cystectomy (LRC).
Methods
In this retrospective study, the clinical data of patients who underwent open and laparoscopic radical cystectomy plus open modified ureterosigmoidostomy urinary diversion in our hospital were collected from January 2011 to December 2019. In addition, perioperative data of 56 patients who underwent ORC and OMUUD were compared with those of 118 patients who underwent laparoscopic radical cystectomy (LRC) plus OMUUD. A long-term follow-up was performed to compare the overall survival (OS) and progression-free survival (PFS) rate between the two groups.
Results
Results showed that the mean operation time in the open group was shorter than that in the laparoscopic group (P < 0.001). Moreover, the estimated intraoperative blood loss༈P < 0.001༉and postoperative hospital stay༈P = 0.023༉were better in the laparoscopic group than in the open group. The incidence of complications between 30 days (P = 0.665) and 90 days (P = 0.211) time-points after surgery was not significantly different. Similarly, the OS (P = 0.237) and PFS (P = 0.307) between the two groups were comparable.
Conclusion
This study shows that the LRC group has long operation time, but less estimated intraoperative blood loss, short postoperative hospital stay, small trauma, and fast postoperative recovery compared to open surgery. Moreover, the incidence of complications at 30-and 90-days postoperation, as well as the OS and PFS is not different between laparoscopy and open surgery.
Current HIV/AIDS Trends among General Public in Telangana: A Cross-sectional Study
Authors: Reddy Adila , Reddy Sunitha
Published: May 2022

Aim: This cross-sectional study aims to investigate the knowledge, attitude, beliefs and practices (KABP) concerning Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) among the general public in the state of Telangana.Introduction: HIV was first reported on June 5, 1981 and has since affected every country across the globe. Worldwide over 37.7 million people are seropositive for Human Immunodeficiency Virus (HIV). Despite large awareness campaigns, inclusive educational curriculum and increased access to healthcare; mainstream understanding about the disease continues to be incomplete. Much of the misunderstanding comes not from the lack of access to information but from the omnipresent misinformation at the community level.Methods: Multiple college campuses were presented with a survey to assess their KABP about HIV/AIDS. The assessment form contained 4 sections as follows, Section 1: Socio-demographic data, Section 2: Knowledge of HIV/AIDS, Section 3: Personal beliefs towards HIV/AIDS, Section 4: Personal Beliefs on Blood Donation and HIV.
The different characteristic of chronic liver damage in patients with metabolic-(dysfunction) associated fatty liver disease in different subtypes
Authors: Wang Yu , Liu Zi-yu , Ji Fang , Dai Ming-jia , Li Jian-zhong , Huang Rui , Wu Chao , Yan Xue-bing
Published: May 2022

BACKGROUND and AIMS: This study aimed to compare the difference on liver damage among MAFLD subgroup classification in MAFLD.METHODS: A cross-sectional study of 882 Chinese patients who underwent ultrasonography or biopsy with metabolic-(dysfunction)-associated fatty liver disease (MAFLD) involved a cohort from a health screening program during the years 2018-2020. The liver damage characteristics of different MAFLD subtypes were compared. Liver damage was assessed based on the inflammation indicators and non-invasive diagnostic model.RESULTS: The median age was 43 years, and 490 (55.56%) patients were male. There was significant difference among three MAFLD subgroups (Group1, 2, and 3) in age, BMI, GGT, TG, CHO, LDL, HDL, FPG, NFS, and FIB-4 (p < 0.05). The FIB-4 and NFS were higher in the Group 2 and the abnormal FPG-level Group than in the other groups to which they were compared (p < 0.05). The age, BMI, and GGT were lower in the only overweight/obese Group than the Concomitant metabolic dysregulation Group (p < 0.05).CONCLUSION: There was statistically difference in liver inflammation and liver fibrosis among different subtypes in MAFLD. It’s urgent to improve substantially in health care for patients and advance disease awareness, public health policy for MAFLD. [197 words]
Comparative chloroplast genomes of six Magnoliaceae species provides new insight into intergeneric relationship and phylogeny
Authors: Yang Lin , Tian Jinhong , Xu Liu , Zhao Xueli , Song Yuyang , Wang Dawei
Published: May 2022

The Magnoliaceae plants are industrial tree species with high medicinal value. We published the 6 complete chloroplast genomes of the family Magnoliaceae by using Illumina sequencing. These 6 chloroplast genomes showed a typical quadripartite structure of angiosperm and were 159,901 − 160,008 bp in size, respectively. A total of 324 microsatellite loci and 6 variable intergenic regions (Pi > 0.01) were identified in 6 genomes. Compare with other 5 genomes, the contraction and expansion of the IR regions were significantly different in Manglietia grandis. For having more thorough understanding of the intergeneric relationship of family Magnoliaceae, we also included 31 published chloroplast genomes of close relative species for phylogenetic analyses. The new insights into intergeneric relationship of family Magnoliaceae was provided based on the combination of our result and the previous morphological, phytochemical and anatomygical information. We suggest that the genus Yulania should be separated from the genus Michelia, and restore systematic position of the genus Yulania; the genera Paramichelia and Tsoongiodendron should be merged into the genera Michelia; the genera Pachylarnax and Parakmeria should be combined into one genus. These findings will provide a theoretical basis for adjustment phylogenetic position of family Magnoliaceae at the molecular level.
DNA Methylation Diagnosis Markers Detection on Lung Adenocarcinoma with Deep Learning
Authors: Yuan Xinyang
Published: May 2022

Lung Adenocarcinoma (LUAD) is one of the most fatal malignant tumors which has led to millions of deaths yearly all around the world. Arouse from new topic of selecting DNA methylation markers in cancer therapy diagnosis, we explore relationship between gene expression and DNA methylation, we applied machine learning unsupervised algorithms in narrowing the range of candidate DNA methylation probes and create a deep-learning-based diagnosis model which has high accuracy in predicting cells into malignant and benign.
The oncogene EIF3c promotes esophageal squamous cell carcinoma tumorigenesis by inhibiting cell proliferation and inducing cell apoptosis
Authors: lu zhengyang , Sheng Binwu , yang Ganghua , Xu Qinhong
Published: May 2022

Background: It has been reported that EIF3c (Eukaryotic initiation factor 3c) was associated with carcinogenesis of several cancer. However, the role of EIF3c in human esophageal squamous cell carcinoma (ESCC) is still unknown. The aim of present study was to explore the relationship between EIF3c and ESCC, and further investigate the effect of EIF3c in ESCC cells and potential molecular mechanism.Methods: The MRNA expression data and the clinical information of ESCC patients was obtained from TCGA and used for the analysis of association between EIF3c and ESCC. SiRNA transfection was performed to knock down EIF3c in ESCC cells. Cellomics ArrayScan, colony formation and CCK-8 assay was used to test cell proliferation. Flow cytometry assay was used to test apoptosis and cell cycle. Western blot assay was used to measure protein expression. Microarray assay and Ingenuity Pathway Analysis (IPA) was used to profile gene expression and physiological processes effected by EIF3c in ESCC cells. Results: Firstly, EIF3c exhibited higher expression in ESCC tissue compared with normal esophageal tissue. Furthermore, silencing EIF3c resulted in cell proliferation inhibition in ESCC cells. In addition, EIF3c knockdown induced cell apoptosis and cell cycle arrest. Moreover, microarray assay and Ingenuity Pathway Analysis (IPA) revealed 1081 differentially expressed genes (DEGS) including 593 upregulated genes and 488 downregulated genes, and the related canonical pathways and possible up-regulators after silencing EIF3c in ESCC cells.Conclusion: Our study for the first time demonstrated the role of EIF3C as oncogene in ESCC and the underlying molecular mechanism.
Distinct patterns of gene expression changes in the colon and striatum of young mice overexpressing alpha-synuclein support Parkinson Disease as a multi-system process
Authors: Videlock Elizabeth Jane , Hatami Asa , Zhu Chunni , Kawaguchi Riki , Chen Han , Khan Tasnin , Joshi Swapna , Hoffman Jill M. , Law Ka Man , Rankin Carl Robert , Chang Lin , Maidment Nigel T. , John Varghese , Geschwind Daniel H. , Pothoulakis Charalabos
Published: May 2022

Background
Parkinson Disease (PD) is increasingly being recognized as a disease of the gut-brain axis. Overexpression of human wild type α–synuclein under the neuron-specific Thy1 promoter (Thy1-haSyn) is a well-characterized mouse model of PD. In addition to a progressive motor phenotype, Thy1-haSyn mice have delayed colonic transit at three months of age mirroring prodromal constipation common in human PD. Identification of initial molecular changes in the gastrointestinal tract in PD could lead to early detection of PD and/or gut-targeted therapies to prevent motor symptoms in PD.
Methods
Colon and striatum gene expression profiling was performed in Thy1-haSyn and wild type (WT) mice aged 1 month and 3 months using 3′ RNA sequencing. Analysis of transcriptomic data included identification of differentially expressed genes, gene set enrichment analysis and weighted gene co-expression network analysis (WGCNA). WGCNA results were further analyzed by linear regression to identify modules most strongly associated with Thy1-haSyn in the colon and striatum, as well as in a combined multivariate model. Module annotation included enrichment for gene ontology terms, cell type signatures and risk genes.
Results
Differential gene expression in Thy1-haSyn vs WT was greater at one vs three months in both the colon and striatum. There was an opposite pattern of enrichment of mitochondrial genes related to PD (KEGG PD pathway) in striatum (enriched in WT) and colon (enriched in Thy1-haSyn). Colon Thy1-haSyn-associated WGCNA modules were enriched for PD risk genes and PD-relevant pathways including inflammation, autophagy, and oxidative stress. When combined with striatum modules, colon modules remained independent predictors of Thy1-haSyn genotype and increased the model fit (p = 0.048).
Conclusions
Overexpression of alpha synuclein acutely disrupts gene expression in the colon. While changes in colon gene expression are highly related to known PD-relevant mechanisms, they are distinct from brain changes and in some cases opposite in direction. These findings are in line with the emerging view of PD as a multi-system disease.
Laboratory Breeding and Rearing of Cellar Spider, Crossopriza lyoni Blackwall
Authors: Mohtar Johan Ariff , Shahimin Mohd Faidz Mohamad
Published: May 2022

Spiders have emerged as one of the leading model organisms in many research fields due to its compelling biology. Often, scientific investigations involving the use of spiders face inevitable problem associated with the lack of specimen from laboratory stock resulting in difficulties to yield reproducible investigations for predictive research. Thus, several species of well-studied spiders including Parasteatoda tepidariorum have been successfully bred for such purpose. Crossopriza lyoni is a cellar spider whose distribution is globally widespread in human inhabitant prompting interest in various studies over the last decades. Despite its scientific importance, no laboratory bred C. lyoni has been documented yet. Herein, we describe a successful captive breeding system of the species under controlled condition to establish laboratory stock culture. Methods for mating induction, egg collection and segregation, artificial embryo incubation, and colony husbandry are discussed. The technique presented here is a simple and low-cost approach that is reliable for C. lyoni propagation in the laboratory over several generations.
A study on different deep learning algorithms used in deep neural nets:MLP SOM and DBN
Authors: J naskath , Sundari Sivagama , Begum Alif Siddiqa
Published: May 2022

Deep learning is a wildly popular topic in machine learning and is structured as a series of nonlinear layers that learn various levels of data representations. To implement various computer models, deep learning employs numerous layers to represent data abstractions. Deep learning approches like generative, discriminative models and model transfers approaches have transformed information processing. This article proposes a comprehensive review of various deep learning algorithms Multi layer perception (MLP), Self-organizing map (SOM) and deep belief networks (DBN) algorithms. It first briefly introduces historical and recent state-of-the-art reviews with suitable architectures and implementation steps. Then the various applications of those algorithms in various fields such as speech recognition engineering, medical applications, natural language processing, material science and remote sensing applications, etc are classified.
COVID-19-How Confinment Affects the Dietary Habits, Physical Activity, and Lifestyle of Work from Home Population in the State of Gujarat
Authors: Solanki Aayushi , Baxi Nishita , Shah Arpi , Akhani Trilok
Published: May 2022

The COVID-19 pandemic in India is part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. India, which has the second-highest population in the world, is suffering from COVID-19 disease. By May18th the country India investigated ~1 lakh (0.1 million) infected cases from COVID-19, and as of 11th July, the cases equalled 8 lakhs. Social distancing and lockdown rules were employed in India due to COVID-19 influenced food habits and lifestyles with potential negative health impact on Indian population. The current research is an attempt to explore physical health; dietary habits; lifestyle changes in working population in state of Gujarat during the lockdown. Approximately, 200 participants from the state of Gujarat were included in the study. They were asked to complete a questionnaire with questions around changes in body weight, junk food consumption or healthy food consumption, physical activities, lifestyle changes before and after the pandemic, sleep quality, screening time, etc.
Assessment of Status, Awareness, and Attitude Associated with Childhood Immunization in Delhi – NCR, India
Authors: Yadav Meena , Singh Jyoti , Kaushik Vidhu , Yadav Himanshi , Nidhi  , Naina  , Mishra Minal
Published: May 2022

Introduction: Immunization is a preventive measure that reduces the occurrence of diseases and child mortality rate. India has made significant progress in this area and continuous efforts are being made to promote a large-scale immunization process for several life-threatening diseases. Aim: Our study was aimed at finding out the immunization coverage and awareness, among mothers, in Delhi – NCR through a sample of 400 respondents. Materials and Methods: The study was conducted through questionnaire-cum-interview and snowball sampling method and included 400 respondents who were mothers having at least one child below 6 years of age. Results: We found that a large percentage of respondents (97.25%) had immunized their children for the recommended vaccines. Mother’s education and occupation were the major influencing forces, with educated and professionally working mothers fairing better, highlighting the importance of female literacy. The full immunization coverage for all five vaccines was 69.27%. Hospitals and doctors were the major sources of information (55.5%) about immunization and more than half of the respondents (55.25%) got their children immunized in government hospitals. Gender of child and economic status of the family were not significant factors affecting immunization. The major factors for not immunizing or delaying the immunization of children were lack of motivation and the busy routine of parents. Conclusion: Female literacy is a major factor influencing immunization success, it should be targeted and not only awareness campaigns but also incentive-based strategies should be employed to create awareness and encourage parents. Complete and timely vaccination of children can protect them from grave diseases and also stop outbreaks of many diseases.
A Comparative Study of White Muscle and Red Muscle Fiber Architectural Parameters
Authors: Kumar Ajay , Jhajharia Birendra
Published: May 2022

The primary objective of this research was to compare red muscle fiber and white muscle fiber muscle architectural parameters of vastus lateralis (VL). The study sample consisted of 70 recreationally active male students from Gwalior, Madhya Pradesh. One repetition maximum Dr. Hatfield test was used to determine muscle fiber type. Thirty (N1 = 15 red muscle fiber group and N2 = 15 red muscle fiber group) out of 70 samples were retained in study for further evaluation. Muscle architectural parameters (VL, pennation angle [PA], fascicle length [FA], and muscle thickness [MT]) were measured using B-mode ultrasonography. Independent sample t-test was employed to determine a significant difference between selected white muscle fibers group and selected red muscle fibers on the basis of selected muscle architectural parameters. The vastus lateralis muscle showed differences in its PA, FA, and MT between different muscle fiber groups. The PA of red muscle fiber group was greater than white muscle fiber group, whereas the FA and MT of white muscle fiber group were greater than red muscle fiber group. In conclusion, architectural parameters studies carried on specific sports group will be helpful in future, and muscle architectural parameters may be considered as a new approach for muscle fiber type classification in the future.
A Cross-Sectional Study to Determine the Use of Online Healthcare Consultancy and Services for Non-communicable Diseases in Middle Age Population during COVID-19 in Bilaspur Chhattisgarh
Authors: Saraswat Avani , Prasad M. Surya Durga
Published: May 2022

The aim of this study is to determine the prevalence of use of online healthcare services in urban population age between 40 and 60 years in Bilaspur Chhattisgarh before and during COVID-19 and also to get idea about convenience, affordability, and satisfaction of online healthcare services for non-communicable diseases during COVID-19 in middle-age adults in Bilaspur. The ethical committee of the University of Hyderabad approved this Cross-sectional study which was done using the cluster sampling method, including five major areas of Bilaspur city. Online questionnaire was used containing 11 compulsory questions (objective type) and 3 questions were optional. Data were analyzed using Microsoft Excel and R studio. Responses of 200 participants who are suffering from non communicable diseases (NCDs) were recorded. The prevalence of participants using online healthcare services before COVID 19 is 22.5 and during COVID 19 is 36. Chi-square test was done in the project for 95% confidence interval and the p value came out to be 0.003001, which is significant. There is a positive correlation between convenience, affordability, and satisfaction. More participants are using online healthcare services during COVID-19 for NCDs in Bilaspur. The use of online healthcare services is more in males compared to females.
Electromyography Based Analysis of the Impact of Ageing on Muscle Activation Pattern during Static and Dynamic Balance Control Tasks: A Systematic Review
Authors: Multani N. K. , Sonia Singh , Sharma Sorabh , Kaur Ralmila Ravinder
Published: May 2022

The present systematic review was done, to examine the impact of aging on posture control mechanisms in terms of muscle activity and sway patterns. English language articles describing effects of aging on muscle activation pattern during balance control tasks using electromyography methods published from 2000 to 2019 were identified. Studies were compared with regards to study population, postural tasks, perturbations, muscle inclusion, and outcome measures. All the included studies (N-9) exhibited increased postural sway among elderly in contrast to young population. In contrast, inconsistency was observed in the muscle activation pattern, muscle dependency, and muscle co-contractions among the studies. Altogether, the findings of the review suggest that the aging causes alterations in muscle activity in order to maintain balance during challenging situations; however, the studies do not elucidate these changes across the ages.
Investigation of Flavonoids in Stereospermum suaveolens DC Leaves (Patala) Using HPTLC Analysis for Inflammatory Pain, Swelling, and Edema Treatment
Authors: Chanshetti R. R. , Bandawane D. D.
Published: May 2022

Background: As per extensive research study, it was observed that Stereospermum suaveolens DC (Patala) is rich sources of flavonoids. These phytoconstituents have played an important role in prevention and maintenance of acute and chronic diseases of pain and inflammation. There is need to explore method for identification and quantification of the presence of flavonoids in S. suaveolens DC leaves (SSL) by qualitatively and quantitatively and to establish its mechanism in pain, swelling and edema Aim: The aim of the study was to identify and assess role of flavonoids in SSL by high-performance thin-layer chromatography (HPTLC) analysis and animal screening models of inflammatory pain, swelling, and edema. Materials and Methods: HPTLC to quantify flavonoid in the ethyl acetate fraction of plant component in comparison with Quarcetin. The inflammatory pain, swelling, and edema method were investigated by acetic acid induced writhing method in mice, histamine-induced edema in Wistar rats, and croton oil-induced ear edema in mice. The test doses 125 mg/kg, 250 mg/kg, and 500 mg/kg oral administration (p.o.) of ethyl acetate fraction of SSL were selected by oral acute toxicity OECD 423. Results: HPTLC analytical method estimated presence of flavonoids and estimated amount was 22.64%. However, inhibition in histamine-induced paw edema and reduction inhibition in ear edema significantly (P < 0.05) observed by dose-dependent effect and antinociceptive activity detected on acetic acid induced writhing response method in mild to moderately using one-way analysis of variance method. Conclusion: It was clear that flavonoids were responsible for direct and indirect release of intermediate inflammatory mediators and promote its role in the treatment of pain and swelling.
Stroke-Related Risk Factors: A Review
Authors: Saini Neha Rani , Gurvendra Amrit Lal
Published: May 2022

Stroke (cerebrovascular accident) is the second leading cause of death and long-term disability worldwide. The major risk factors of stroke are categorized as modifiable and non-modifiable. Modifiable risk factors include hypertension, diabetes mellitus, heart disease, hyperlipidemia, obesity, and smoking. Non-modifiable risk factors include age, genetic, gender, and race. Risk factors that are specific to women including pregnancy, postpartum period, and oral contraceptives, some psychological factors such as stress and depression are linked to stroke. The burden of stroke is increasing globally. Furthermore, because stroke treatment is not satisfactory, significant effort should be focused on reducing risk factors to reduce the disease’s effects. The current study will provide a better understanding of risk factors associated with stroke that may further lead to improved prevention of stroke.
A Review on Curcumin and its Use as Novel Drug Delivery System
Authors: Vashist Shweta , Sharma Sujata , Kumari Jyoti , Gadewar Manoj , Arora Sahil
Published: May 2022

Curcumin is a principle compound obtained from turmeric, that is, Curcuma longa which is Indian rhizomatous medicinal plant from the family Zingiberaceae. Curcumin is yellow pigment commonly used as a spice in food processing industry. Curcumin, Demethoxycurcumin, and Bisdemethoxycurcumin are the major active constituents of the turmeric and are collectively known as curcuminoids. In recent studies, it has been demonstrated that curcumin has a variety of biological activities, pharmacological performances, provide protection, and promotion of health. This paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, cancers, diabetes, liver, and cardiovascular systems. The curcumin belongs to biopharmaceutical classification system Class IV that indicates low solubility and low permeability. The systemic bioavailability of orally administered curcumin is low in humans and only traces of it have been found in the liver. Here, we emphasized its broad therapeutic activity in treating life-threatening diseases by improving solubility as well as permeability with the help of novel drug delivery system.
Study of Lumbosacral Posture and Pelvic Angle in Odissi Classical Dancers
Authors: Yalavatti Tanushree , Pawar Shradha
Published: May 2022

Background: This study was designed to find out the prevalence of backache due to musculoskeletal injuries in Odissi dancers and the influence of lumbar posture and pelvic angle in causing backache. Methods: Study design: This was a cross-sectional and observational study; Sample size: 60 numbers were classified into, Group A: 20 - Normal Individuals, Group B: 20 - Beginner Odissi dancers, and Group C: 20 - Advanced Odissi dancers. Inclusion criteria: 1) Normal individuals between 20 and 24 years of age not trained in Indian classical dance, 2) Odissi dancers trained for <2 years- Beginner’s group, and 3) Odissi dancers trained for more than 10 years - Advanced group. Exclusion criteria: 1) People trained in other forms of dance, other than Odissi, and 2) recent MSK injuries. Assessment of lumbar posture and the pelvic angle performed using flexicurve and pelvic inclinometer. Results: 1) Inter group comparison of mean Pelvic angle (degree): Pelvic angle (degree) was higher in Group 2 in comparison to other two groups and was statistically significant with P < 0.01. Pelvic angle (degree) was also observed to be statistically significant between the Groups 1 versus 2 (P < 0.01) and 1 versus 3 (P < 0.05). 2) Inter group comparison of mean of Lumbar lordosis angle {Theta angle (θ)} using turkey post hoc tests: There was no statistical significance between either groups for theta angle. Conclusion: This study reveals that pelvic angle in the beginner and advanced group of Odissi dancers was altered in comparison to the non-dancer group, though statistically significant needs further evaluation in larger population of Odissi dancers.
Assessment of Pulmonary Function Test among Petrol Pump Workers in Bankura District
Authors: Karak Prithviraj , Maiti Rajkumar
Published: May 2022

Background and Aim: Health problems posed by the pollutants at the working environment of an individual are linked to the nature and level of exposure to these hazardous chemicals. Petrol pump workers are exposed to high level of different types of air pollution along with petrol and diesel vapors exhibit a number of effects on the respiratory functions. The main objective of the study was to assess the pulmonary functions in petrol pump workers (filling attendants) who are continuously exposed to petrol/diesel vapors during duty hours and compare with the normal healthy individuals. Materials and Methods: This is a cross-sectional study was conducted at seven different petrol pumps of Bankura and 65 petrol pump workers (filling attendants) were included. Each subject’s age, smoking habits, the duration of exposure, health conditions, BMI and BP were recorded. Their PFT were assessed using spirometer and was compared with 65 normal healthy individuals. Results: A significant decrease in the values of Tidal Volume, Vital Capacity, Peak Expiratory Flow Rate, Maximum Voluntary Ventilation, Respiratory Rate and Oxygen saturation in petrol pump workers when compared to control group. Significant increase in BP was observed in case of petrol pump workers and reduction in muscle strength. Conclusion: The present findings demonstrate the adverse effects of petrol and diesel vapors and fumes, hydrocarbons markedly decreased the pulmonary functions.
Beneficial Effects of Soy Isoflavones on Blood Pressure and Lipid Profile in Indian Postmenopausal Women
Authors: Husain Shazia , Bhatnagar Vibha
Published: May 2022

Background: The studies have suggested that dietary isoflavones intake in postmenopausal women had protective role against cardiovascular disease (CVD). Objectives: This study ascertained the effect of isoflavone in the form of soyflour on lipid profiles and blood pressure (BP) in postmenopausal women diagnosed with medium risk of CVD. Materials and Methods: It was a 16-week placebo controlled trial that was conducted on 60 postmenopausal women aged 45–55 years. Participants in the treatment group were provided with 40 g soyflour/day for 16 weeks. The participants in the control group were asked not to change their usual dietary habits and lifestyles and were instructed to avoid taking soybean and soybean products. The changes in BP and blood lipid profile were measured at baseline and at the end of the study. Results: There were non-significant differences in any of the variables between two groups at baseline. Biochemical results indicated the beneficial effect of intervention in significantly reducing systolic (6.28%) and diastolic (4.73%) BP of the treatment group. It also exhibited an effective role in significantly (P < 0.05) reducing the serum cholesterol (17.29%), triglyceride (22.22%), low density lipoprotein (24.53%), very low density lipoprotein (22.21%), and significantly increasing the high density lipoprotein (13.55%) in the treatment group. Conclusion: The study indicates that daily administration of 40g soyflour for 16 weeks improved the BP and lipid profile of postmenopausal subjects.
Impact of Covid-19 on Active Lifestyle, Physical Activity Behaviour and Physical Fitness of Adult Male Sportsmen of Delhi
Authors: Dhirender Tokas , Gopal Kumar , Ashish Phulkar
Published: May 2022

Introduction:- The spread of COVID 19 infection led to nationwide lockdown and posed many difficulties for people to perform physical activities. Statement of Problem: The present study focuses on the impact of this COVID virus & precautionary lockdown on the physical activity behavior, active lifestyle and physical fitness of adult male sportsmen of Delhi. Methodology: 500 sportsmen from all over Delhi were chosen through convenience sampling technique, who were actively participating in sports & physical activities pre lockdown phase and their responses were recorded through a self-constructed questionnaire that consisted of 14 questions related to active lifestyle, physical activity routine pre & post lockdown, condition of their physical fitness & their views regarding future. Data Analysis:- The data collected was analyzed through descriptive statistics. Results: The results thus obtained revealed that the subjects emphasized on the active lifestyle, the fitness levels were affected adversely due to lockdown because of various reasons discussed in the paper. The results also revealed that although it was a great learning to perform physical activities through digital platform, but it should not be emphasized over traditional training methodology and the way to proceed in the future is the old way.
Optimization of Support Vector Machine Classifier Using Grey Wolf Optimization Algorithm for Chronic Kidney Disease Prediction
Authors: Sharma Pallavi , Kaur Gurmanik
Published: May 2022

The massive generation of medical data from smart health-care applications in recent years necessitates the development of big data classification strategies. Medical data classification can be used to visualize patterns in the data and detect the presence of the disease in medical data. We present an efficient support vector machine (SVM) hybridized with a grey wolf optimization (GWO) algorithm for chronic kidney disease (CKD) data classification in this work. Initially, infinite feature selection (IFS) algorithm is used to select the best features from a set of available features. The dataset’s selected features are processed and fed into the GWO optimized SVM algorithm. The proposed CKD classification strategy has been simulated in MATLAB. CKD dataset from UCI machine learning repository is utilized for testing the developed strategy. The performance of the proposed CKD classification strategy is examined by accuracy and root mean square error (RMSE) values. According to the investigational findings, the proposed CKD classification system achieved accuracy and RMSE value of 97.58% and 0.1581, respectively, for classifying subjects into the CKD and non-CKD categories. The performance of GWO optimized SVM algorithm is outstanding, according to the experimental observations.
Eksistensi Perempuan: Kritik Sastra Feminis, Perempuan sebagai Pembaca Kidung Agung 3:1-5
Authors: Kelelufna Jusuf Haries , Pettiserlihun Selvone
Published: May 2022

AbstractThe growing involvement of women in various fi elds and at various levels does not negate patriarchal culture in the forms of discrimination and violence against women. Religion contributes to the persistence of patriarchal culture through the male-oriented interpretation of sacred texts. This article reinterprets the text of Song of Songs 3:1-5 withthe method of feminist literary criticism according to Elaine Showalter to explain the existence of women implied in the text. The data were analyzed with the stages of interpretation, analysis, and assessment. The results of the analysis show that women, as independent individuals, play important roles in the family and society. The implied authorcriticizes the domination of men over women but, on the other hand, acknowledges the possibility that women also contribute to patriarchal model.

Abstrak Ada perkembangan keterlibatan perempuan dalam berbagai bidang dan di berbagai tingkatan. Namun demikian tidak dapat dinafikan bahwa dominasi budaya patriarki memunculkan fenomena diskriminasi dan kekerasan terhadap perempuan di mana agama berkontribusi terhadap diskriminasi dan kekerasan tersebut. Kontribusi agama dilakukan lewat tafsir kitab suci yang didominasi oleh budaya Patriarki. Upaya teologis untuk memaksimalkan peran perempuan adalah dengan menafsirkan kembali teks-teks Alkitab dengan pendekatan feminis. Penulis menafsirkan teks Kidung Agung 3:1-5 dengan metode kritik sastra feminis perempuan sebagai pembaca menurut Elaine Showalter untuk menjelaskan eksistensi perempuan serta maksud pengarang tersirat dalam teks tersebut. Data dianalisis dengan tahapan interpretasi, analisis, dan penilaian. Hasil analisis menunjukkan perempuan sebagai pribadi yang mandiri, berperan penting dalam keluarga dan masyarakat. Pengarang tersirat mengkritisi dominasi laki-laki atas perempuan tetapidi sisi lain ia mengakui adanya kemungkinan bahwa perempuan turut berkontribusi bagi dominasi laki-laki terhadap perempuan.
The The Boti-Christian Engagement in Interreligious Cultural Dialogue: Response to Environmental Crisis on Timor Island
Authors: Rustyana Nezia Mavitau
Published: May 2022

AbstrakArtikel ini bertujuan membangun dialog budaya lintas agama antara penganut agama asli Boti dan umat Kristiani di Timor Tengah Selatan, Nusa Tenggara Timur. Fokus kajian tertuju pada dua fenomena: krisis lingkungan artifisial yang berakar pada paradigma Kristen barat yang mengunggulkan modernisme, dan fenomena konversi yang tidak ramahterhadap masyarakat asli. Fenomena tersebut mencakup berbagai kenyataan sehubungan dengan peran komunitas Boti dalam ritual dan praktik kehidupan sehari-hari, yang mengusung nilai-nilai ekologis yang berakar pada pengetahuan setempat. Paradigma yang dipakai orang Boti terbentuk dari pengalaman interpersonal antara manusia dan alam.Pandangan itu telah menolong mereka melewati kekeringan yang panjang yang disebabkan oleh faktor alam sebagai dampak dari krisis lingkungan di Timor. Artikel ini menggugat pengaruh kekristenan yang menggunakan pandangan barat, dan mengusulkan untuk menggantinya dengan sebuah teologi yang menghargai tradisi Boti. Sehubungan dengan itu, artikel ini menggarisbawahi kritik terhadap konsep superioritas manusia terhadap alam sebagaimana terkandung di dalam Alkitab, kemudian menawarkansebuah konsep hubungan yang lebih serasi antara alam dan manusia di mana penghargaan dan pemeliharaan alam adalah wujud hubungan yang harmonis dengan Tuhan.

Abstract This article aims to build an inter-religious cultural dialogue between Boti indigenous people and Christians, South Timor Tengah, East Nusa Tenggara. It responds to two phenomena: the artifi cial environmental crisis rooted in the western paradigm of Christianity glorifying modernism and expanded with the phenomenon of conversionthat is not friendly to indigenous peoples. The phenomena cover various facts about the role of the Boti community in their rituals and daily practices, which have promoted ecological values derived from their local knowledge. The Boti people uphold the indigenous paradigm through their interpersonal relationships with nature. This view has helped them face the long drought due to the natural factor of the environmental crisis in Timor. This article criticizes the influence of Christianity using the western view by replacing it with theology in appreciating local knowledge of Boti indigenous peoples. It also criticizes the human superiority in the Bible toward nature by offering a harmonious relationship between the two that humans should respect and preserve nature to maintain a harmonious relationship with God.
Allah Transenden yang Ditangguhkan: Kristus Pengharapan Eskatologis dalam Jürgen Moltmann dan Slavoj Žižek
Authors: Albungkari Albungkari
Published: May 2022

Abstract This article aims to offer suspended transcendent God as an alternative for the thoughts of Jürgen Moltmann and Slavoj Žižek. Although they place Christ as the basis of eschatological hope, they have different opinions regarding the involvement of a transcendental entity (God). If Moltmann emphasizes on God’s intervention in the fulfillment of eschatologicalexpectations Žižek rejects the involvement of transcendental entities by assuming that the divine has died so that the responsibility is transferred to humans. Departing from the lens of Ernst Bloch’s speculative materialism, this article concludes with a construction of a suspended transcendent God. This concept neither accepts nor rejects God’s intervention, but sees it as a speculative possibility.

Abstrak Artikel ini bertujuan menawarkan Allah transenden yang ditangguhkan (suspended transcendent God) sebagai alternatif pemikiran Jürgen Moltmann dan Slavoj Žižek. Meskipun sama-sama menempatkan Kristus sebagai dasar pengharapan eskatologis, akan tetapi keduanya berbeda pendapat perihal keterlibatan entitas transendental (Allah).Jika Moltmann sangat menekankan intervensi Allah dalam pemenuhan pengharapan eskatologis, maka Žižek menolak keterlibatan entitas transendental dengan menganggapyang Ilahi telah mati sehingga tanggung jawab tersebut dialihkan pada manusia. Berangkat dari lensa materialisme spekulatif Ernst Bloch, artikel ini ditutup dengan konstruksi mengenai Allah transenden yang ditangguhkan. Konsep ini tidak menerima maupun menolak intervensi Allah, melainkan melihatnya sebagai kemungkinan spekulatif.