bluuebunny/crossref_metadata_2025 huggingface dataset:
Complex Approach to the Management of Acneiform Rash Induced by Epidermal Growth Factor Receptor Inhibitors
Authors: Kruglova Larisa S. , Shatokhina Eugenia A. , Polonskaia Aleksandra S.
Published: February 2024

Rationale. Acneiform (papulopustular) rash is the leading dermatological adverse event of EGFR inhibitors. The development of optimal regimens for the supportive treatment of acneiform rash remains an important interdisciplinary problem in supportive oncology. Aims — to comparatively evaluate the clinical efficacy of the supportive treatment for acneiform rash induced by epidermal growth factor receptor inhibitors, including topical treatment with ivermectin cream and balneotherapy. Methods. In an open, prospective, randomized study, data from 114 patients with acneiform rash induced by monoclonal antibodies to EGFR were analyzed. All groups received intermittent supportive treatment according to a single regimen, continuous external therapy included: in group 1 — hypotonic thermal water, in group 2 — ivermectin 1% cream, in group 3 — hypotonic thermal water and ivermectin 1% cream. The observation period was 3 months. Acneiform rash severity was assessed using the CTCAE-NCI v5.0 criteria and a developed acneiform rash clinical severity scale. The intensity of subjective symptoms was assessed using a 10-point visual analog scale (VAS). The modified dermatological life quality index (mDLQI) was used to assess the impact of acneiform rash on patient’s quality of life. Results. A significant decrease in all of the studied parameters was observed in the groups by the end of the 1st week of supportive treatment and remained up to the end of the observation period (p 0.05). There were no statistically significant differences between groups 2 and 3 with respect to the acneiform rash clinical severity scale, but their values were significantly lower than those of group 1 (group 1 vs. group 2, p 0.001; group 1 vs. group 3, p 0.001). The most rapid resolution of all subjective symptoms was observed in group 3. Significantly lower mDLQI values were also observed in group 3 starting from the 1st week of supportive treatment until the end of the follow-up period (р 0.05). No severe adverse reactions were registered in any of the groups during the study. Conclusions. The developed regimens for the supportive treatment of acneiform rash have demonstrated a high efficacy in resolving papulopustular rash and associated subjective symptoms. The use of a complex approach including continuous topical therapy with ivermectin cream and hypotonic thermal water leads to the resolution of rash and relief of subjective symptoms in the shortest time, allows to safely maintain the achieved clinical effect for a long period of observation, has the most significant positive impact on the quality of life of cancer patients.
The Theory of Self-Regulation of Parasitary Systems and COVID-19
Authors: Akimkin Vasily G. , Semenenko Tatiana A. , Dubodelov Dmitry V. , Khafizov Kamil  F. , Ugleva Svetlana  V.
Published: February 2024

Background. The COVID-19 pandemic once again confirmed the correctness of the theory of Academician V.D. Belyakov, according to which the basis for the development of the epidemic process is a phase change in the heterogeneity of the biological properties of the interacting populations of the pathogen and humans. In accordance with the theory of self-regulation of parasitic systems, changes are associated not only with genetic variability, but also with other polydeterminant characteristics of the pathogen: when new genovariants appeared, SARS-CoV-2 became less pathogenic for humans, but more contagious. This circumstance is important not only for theoretical, but also for practical epidemiology, as it makes it possible to predict the direction of development of the epidemic situation.
Aims — to evaluate the manifestations of the epidemic process of the new coronavirus infection COVID-19 through the prism of the theory of self-regulation of parasitic systems.
Methods. An epidemiological retrospective analysis of the incidence of COVID-19 was carried out, including the study of absolute and intensive incidence rates per 100,000 population, the dynamics of changes in the properties of the coronavirus population, and the identification of SARS-CoV-2 genovariants for the period from 03.2020 to 04.2023. To analyze SARS-CoV-2 genovariants at various stages of the pandemic, we used sequencing data presented on the SARS-CoV-2 genome information aggregation platform Virus Genome Aggregator of Russia (VGARus) — more than 248 thousand genetic sequences.
Results. During the pandemic, there have been seven ups and downs in the incidence of COVID-19. During the period of circulation in the human population and adaptation to a new host, a significant amount of data has accumulated on the evolutionary changes in the SARS-CoV-2 genome, taking into account the trends in the acquisition of new epidemiological properties.
Conclusion. An analysis of the manifestations of the epidemic process of COVID-19, as a classic aerosol anthroponosis, confirmed the correctness of the theory of Academician V.D. Belyakov, according to which the basis of its development is a phase change in the heterogeneity of the biological properties of the interacting populations of the pathogen and humans, based on negative feedback in the process of self-regulation.
Micro-RNAs in the Diagnosis of Cutaneous T-Cell Lymphomas
Authors: Olisova Olga Yu. , Amshinskaya Jessika R. , Demkin Vladimir V.
Published: February 2024

Rationale. Early diagnosis of mycosis fungoides (MF), as the most common form of T-cell lymphoma, presents significant challenges. The diagnosis of MF is based on the following criteria: comprehensive assessment of the clinical picture of the disease, histological and immunohistochemical examination of the skin, and determination of rearrangement of the T-cell receptor gene, but even this does not always aid in diagnosis. The aim of the study is to investigate the expression of micro-RNAs (miR-223, -423, -663, -16, -326, -711) in the blood plasma and leukocytes of patients with a presumptive diagnosis of MF to improve the disease diagnosis. Methods. This study included 50 patients aged 24 to 79 years, of whom 30 patients had a preliminary diagnosis of MF and 20 patients with small plaque parapsoriasis, who formed the comparison group. All patients underwent histological, immunohistochemical examination of skin biopsies, and determination of micro-RNA (miR-223, -423, -663, -16, -326, -711) expression in blood plasma and leukocytes by real-time PCR. Results. Analyzing the results of clinical-anamnestic, histological, and immunohistochemical research methods, the diagnosis of MF was established in 22 of 30 (73.3%) patients, of which 9 of 14 (64.3%) were in the early stages of the disease. small plaque parapsoriasis. Conclusion. During our study, it was found that the studied micro-RNAs (miR-326, -663, -711, -223, -423, -16) in the blood plasma and leukocytes of patients with MF have statistically significant levels of expression compared to the low level of expression of these micro-RNAs in patients with small plaque parapsoriasis. The expression of micro-RNAs we studied in the skin contributes to the improvement of MF diagnosis with an accuracy of up to 90%.
Autoimmune Skin Diseases in Multiple Sclerosis: Comorbidity Issues and the Impact of Pathogenetic Therapy
Authors: Dvornikov Anton S. , Gusev Evgeny I. , Martynov Michail Yu. , Lashch Natalia Yu. , Gaydina Tatyana A. , Chukanova Anna S. , Boyko Alexey N.
Published: February 2024

The number of autoimmune diseases (AS), currently numbering more than 100 nosological forms, is constantly growing and is a significant problem of clinical medicine. Advances in the definition of diagnostic biomarkers and clinical tests make it possible in most cases to carry out differential diagnosis of autoimmune pathology and prescribe personalized immunocorrection. The modern understanding of the mechanisms of AS is based on the breakdown of tolerance to their own antigens, which occurs in genetically predisposed individuals against the background of impaired immunoregulation. In this review, using the example of multiple sclerosis (MS) as a classic AS of the nervous system, a possible combination of common autoimmune mechanisms of MS and such common skin diseases as psoriasis and atopic dermatitis is considered. Advances in the field of pharmacy have accelerated the path from the creation of new molecules to the introduction of modern pathogenetic drugs into daily clinical practice. To prevent exacerbations and progression of MS, disease-modifying therapy of MS are currently used. This treatment is permanent and long-term, and it is very important to take into account the comorbid pathologies that develop against the background of this therapy. The review shows the effect of DMT on the manifestation of skin diseases. The use of modern bioengineered drugs can contribute both to the activation and emergence of new diseases, and to stabilize the patient’s condition in the presence of autoimmune comorbidity.
Electrical Instability of the Myocardium in Children and Adolescents
Authors: Balykova Larisa A. , Shirmankina Marina V. , Ivyanskiy Stanislav A. , Krasnopolskaya Anna V. , Vladimirov Denis O. , Shablinova Tatyana S. , Tyagusheva Evgenia N.
Published: February 2024

Currently, there is no doubt that the problem of electrical instability of the myocardium in pediatric cardiology is relevant. The determination of various indicators of electrical instability of the myocardium, which are predictors of life-threatening rhythm disorders and sudden cardiac death, presents an underdeveloped task not only for functional diagnostics specialists, but also for pediatricians, neonatologists, pediatric cardiologists and doctors of other specialties. Non-invasive research methods such as electrocardiography (ECG), Holter ECG monitoring (HM ECG), available in almost all pediatric treatment and prevention institutions, are quite informative in terms of detecting electrophysiological heterogeneity of the myocardium as a predictor of sudden cardiac death, which is especially important in children at risk, as well as young athletes. Thus, the determination of indicators of electrical instability of the myocardium is of great interest, it is a promising direction in modern clinical practice, allowing to predict the risk of developing fatal arrhythmias in children and adolescents.
To the 75th Anniversary of Academician of the Russian Academy of Sciences Evgeny Lvovich Nasonov
Authors: Reshetov Igor V. , Usoltseva Natalia I. , Sergeeva Natalia V. , Serikov Alexei A.
Published: February 2024

On September 4, 2023, the 75th anniversary of the largest scientist, clinician and innovator, a talented teacher in the field of rheumatology, an outstanding healthcare organizer, scientific director of the Federal State Budgetary Scientific Institution “V.A. Nasonova Research Institute of Rheumatology”, Honored Scientist of the Russian Federation, Academician of the Russian Academy of Sciences Evgeny Lvovich Nasonov.
To the 85th Anniversary of Academician of the Russian Academy of Sciences Valery Konstantinovich Leontiev
Authors: Reshetov Igor V. , Usoltseva Natalia I. , Sergeeva Natalia V. , Serikov Alexei A.
Published: February 2024

On January 24, 2024, the largest scientist in the field of dentistry, an outstanding organizer of health care at the state level, laureate of the State Prize of the Russian Federation in the field of science and technology, Honored Scientist of the Russian Federation, Academician of the Russian Academy of Sciences Valery Konstantinovich Leontiev, turned 85 years old.
Comparative Evaluation of the Results of Radical Surgical Treatment of Patients with Muscle-Invasive Bladder Cancer
Authors: Startsev Vladimir Yu. , Sarychev Sergey V. , Tyapkin Nikolay I. , Kondratiev Gleb V.
Published: February 2024

Malignant neoplasms of the bladder with invasion into the muscle layer of the organ wall (MIBC) are recognized as a highly aggressive pathology with a poorly predicted outcome, a high mortality rate, involving patients of any age without gender differences. Radical surgery’s in patients with MIBC has long and highly established itself as one of the main methods of treatment. However, the results of open surgical interventions are still accompanied by a high level of complications. The materials of medical literature (PubMed, CrossRef) for 2000–2023 were studied, with the issues of comparative evaluation of the results of surgical treatment of patients with MIBC, complications of the postoperative period. The search was conducted on the key phrases “bladder cancer”, “open cystectomy”, “robot-assisted cystectomy”, “cancer-specific survival”. The widespread introduction of video-endoscopic methods of treating patients with this disease into clinical practice has made it possible to speak about a decrease in the volume of intraoperative blood loss, the frequency of infectious complications of the wound and inpatient stay. The development of robot-assisted bladder surgery (RARC) demonstrates a number of advantages of using the daVinci robot in terms of reducing the number of postoperative complications during the traditional to study the 30–60–90-day follow-up periods. The issues of rehabilitation of patients after various methods of urine diversion, the medical-economic aspects for RARC in expert urological centers and the feasibility of the widespread introduction of this technique in medical institutions remain unclear. The coverage of these issues in the medical scientific literature is ambiguous, and therefore requires additional analysis.
Evolution and Perspectives of Anesthesia and Analgesia Techniques for Coronary Artery Bypass Grafting
Authors: Paromov Konstantin V. , Svirskii Dmitii A. , Kirov Mikhail Yu.
Published: February 2024

For more than 60-year history of coronary artery bypass grafting, surgical techniques and specialists’ competence were improved as well as the safety of anesthesiological management. This analytical review discusses modern features of analgesia during coronary surgery and early postoperative period. We described current opinion on perioperative administration of opioids and modern methods of analgesia, taking into account possible complications of their use. Despite the low mortality and overall safety of coronary bypass grafting nowadays, the optimal strategy of analgesia for this surgery is not established yet. This review lists routinely used analgetics and some aspects of their use in cardiac anesthesiology, outlines trends and prospects for the introduction of new drugs and techniques for analgesia. Despite a number of restrictions on the use of opioids in intensive care in modern era, in cardiac anesthesiology their use remains justified and, under certain conditions, safe enough.
RESULTADOS SABER PRO-2018 EN ADMINISTRACIÓN POR REGIONES DE COLOMBIA
Authors: Rincón-Báez William Umar , Becerra Plaza Gisèle Eugenia , Arias-Velandia Nicolas
Published: February 2024

Para el décimo boletín del Observatorio en Ciencias Administrativas de ASCOLFA, se plantea el análisis de los resultados de los estudiantes que presentaron el examen ICFES Saber Pro en 2018 por los capítulos regionales que conforman la Asociación Colombiana de Facultades de Administración -ASCOLFA- (Figura 1). La información se obtiene de las bases de datos de los resultados en las competencias genéricas que se encuentran en FTP- ICFES1 y se cruza con las bases de las IES que conforman ASCOLFA. Se puede revisar información de resultados nacionales de la prueba SABER PRO-2018 en el Boletín 2 del Observatorio de Ciencias Administrativas:”  RESULTADOS SABER PRO-2018 POR GRUPOS DE REFERENCIA” (Rincón-Báez, Becerra, & Arias-Velandia, 2019).
RESULTADOS SABER PRO 2017 DE LOS CAPITULOS DE ASCOLFA
Authors: Rincón Báez William Umar , Becerra Plaza Gisèle Eugenia
Published: February 2024

En este Boletín se hace un análisis de los resultados de la prueba Saber Pro comparando los resultados a nivel nacional con los resultados de cada uno de los capítulos, teniendo en cuenta algunas de las características de las Instituciones de educación Superior (IES). Todos los datos se toman del FTP_ICFES, con los resultados del examen Saber Pro 2017.
Oxidation Kinetics of Iron-Chromium and Iron-Chromium-Aluminium Alloys
Authors: Nakhutsrishvili Irakli
Published: February 2024

The paper presents a mathematical model to describe thermogravimetric curves of the growth of scale with its simultaneous sublimation during oxidation of the surface of a metal or alloy. For alloys iron-chromium and iron-chromium-aluminium, a decrease in the effective reaction area as a result of the formation of the oxide of the alloying element lanthanum or yttrium (together with the formation of the main oxide: chromia or alumina) is considered. For metals, the case of increasing this area is also considered. During the oxidation of the chromia-forming alloy, another secondary process is added: the evaporation of chromia. Therefore, the equations describing the kinetics of changes in mass of these alloys are different. Equations are also considered that make it possible to describe the kinetics of the oxidation process taking into account the initial non-isothermal heating. The formal equations of the oxidation process with an increase in the reaction surface as a result of crushing metal powder are also considered. The resulting equations are used to describe the kinetic curves of changes in the mass of the samples under study. The given equations can be considered as a more accurate approximation to describe the experimental data than the formulas known so far.
Tensile performance of 3D printed geogrids: effect of geometrical configuration
Authors: Shirdel Milad , Farzam Masood
Published: February 2024

The aim of this study was to evaluate the tensile performance of additively manufactured polyethylene terephthalate glycol (PETG) geogrids, printed three-dimensionally using the material extrusion technique. The Creality Ender-3 V2 printer was employed for this purpose. The printed specimens were subjected to loading at a rate of 1 mm/min until failure occurred. The geometrical parameters investigated were the shape of the aperture (square, triangular and hexagonal), the aperture size, the rib thickness and the type of junction. The results revealed that the failure of specimens was primarily brittle and independent of any specific geometrical configuration or modifications. The initiation of failure consistently originated from the junctions. Among the specimens with typical junctions, the triaxial geogrids exhibited the highest tensile capacity; among geogrids with modified junctions, the square geogrids performed the best. The load capacity of the geogrids was found to be primarily governed by linear behaviour in terms of rib width, regardless of the aperture size or shape, whereas a non-linear regression model characterised the load–displacement curves. The results indicate that it is important to account for geometrical non-linearity in specimens with hexagonal apertures.
THE ROLE OF TEACHER IN THE EDUCATION OF MULTICULTURAL PERSONALITY
Authors:   Bishkek State University named after K. Karasaev, Seitkojoeva Zamira
Published: February 2024

This article describes the role of teachers in the multicultural education of students and the younger generation. The modern paradigm of education focuses the school on the implementation of such training, in which the pupil must be involved in educational activities, was able to change themselves in accordance with those moral foundations, which will be considered national and universal achievements. Training should be personality-oriented, carrying out an individual approach to the pupil. It is also necessary to prepare and train modern employees of the educational sphere for the organization of assistance to students in the formation of multicultural mentality, so they can teach students to see problems in intercultural communication, avoid, prevent social conflicts. In the education of interpersonal relationships, that arise between students, grouped into various associations according to different interests and abilities it's not just the role that matters public associations, parents', but the role of the teacher is important
ABDYKALIK CHOROBAYEV AND BAIMBET ABDRAKHMANOV (THE ISSUE OF A MENTOR AND HIS FOLLOWER)
Authors:   Institute of Language and Literature named after Ch. Aitmatov, Zhamangulova Nazira
Published: February 2024

Bayimbet Abdrakhmanov (Togolok Moldo) - was born in 1860 in the village of Kurtka, Ak-Talaa region and died in 1942. Poet and Manaschi. Abdykalyk Chorobaev is a representative of Kyrgyz poets, was born in 1896 in the village of Kurtka, Ak-Talaa district, Naryn region, and died on December 11, 1979. These two great talents were born in Kurtka, Naryn Oblast, and contributed to the Kyrgyz art of speech, especially handwritten literature. The age difference between the two great poets are 36 years. From the first day of his acquaintance with Baiymbet (Togolok Moldo), Abdykalyk Chorobaev, for 29 years followed his teacher, like he was a father and studied the art of creativity. These great talents traveled the country, collected and recorded many legends and myths. The article analyzes the role, significance and characteristics of both great poets in the study of art, teaching and apprenticeship.
POSTOPERATIVE REHABILITATION OF PATIENTS WITH MAXILLOFACIAL ANOMALIES
Authors:   Osh regional united clinical hospital, Yeshiev Daniyar , Yeshieva Aselya ,   Kyrgyz State Medical Institute of Post-Graduate Training and Continuous Education named after S. B. Daniyarov, Taalaibekov Nursultan , Yeshiev Abdyrakman ,   Osh regional united clinical hospital
Published: February 2024

The article discusses the results of research in the field of rehabilitation of postoperative patients with developmental anomalies of the dentition and deformities. The study was carried out on the basis of the Osh Interregional Joint Clinical Hospital in the Department of Maxillofacial Surgery. The study was conducted in 104 patients, of whom 42 were women and 62 were men. The study was carried out using the methods of stage-by-stage rehabilitation in the postoperative period, in addition to echo-osteometric examination of bone tissue. The model of postoperative rehabilitation of patients with lower and upper prognosis, which we used, including three stages, is based on the principle of creating optimal conditions for bone wound healing. As applied to patients with superior prognosis, it is achieved by the method of rigid fixation of osteotomized fragments using mini-plates and a bracket system with such an arrangement of fixing elements that form a quadrangular system of resistance forces that holds the displaced fragments in the achieved ratio.
COMPARATIVE CHARACTERISTICS OF KARYOTYPES OF TWO FOREST MOUSE POPULATIONS APODEMUS SYLVATICUS L., 1758
Authors:   Kyrgyz State Medical Academy named after I. K. Akhunbayev, Eralieva Nurgul , Karipova Nazgul ,   Kyrgyz National University named after J. Balasagyn
Published: February 2024

Sary-Chelek Biosphere Reserve, according to literature data, is seismically active. The study of the chromosome composition of vertebrates living in this reserve makes it possible to trace the relationship between physical factors of the environment and heredity. It is great importance for the conservation of the species in the reserve. The article presents materials on the analysis and comparative cytogenetics of the wood mouse of two populations living in the state biosphere reserve Sary-Chelek and the natural reserve Karatal-Zhapyryk. The Karatal- Zhapyryk reserve is not a seismically active region. In the studied areas, cytogenetic research were carried out for the first time. Also in the framework of this research the morphology and the number of chromosomes of wood mice were studied. The mitotic chromosomes slides were prepared from bone marrow cells by the method of Ford and Hamerton (1956). The chromosome composition of the wood mouse of the Sarychelek population is 2n = 48, NF = 46, the karyotype of the Karatalzhapyryk population is 2n = 48, NF = 46, all chromosomes of the studied populations are acrocentric, making up a gradually decreasing series of chromosomes. Sex chromosomes are also acrocentrics. According to the results of a comparative analysis of the karyotypes of two wood mouse populations, no differences were found in the structure of chromosomes, which is consistent with the literature data, but aneuploid cells were found in the karyotype of the wood mouse of the Sarychelek population.
ALGORITHM FOR DETECTING HYDROCARBON LEAKS IN PIPELINE TRANSPORT WITH INTERMEDIATE REMOVAL OF PART OF HYDROCARBON
Authors: Shestakov R.A. , Makulov D.R. , Matveeva Yu.S.
Published: February 2024

Currently, the main part of hydrocarbons consumed both in the Russian Federation and in the world as a whole is transported through pipelines. This type of transport has many advantages, however, despite this, problems arise during operation related to ensuring the integrity of the pipelines themselves and providing settlements located along the linear part with fuel using intermediate branches to local oil depots. It is worth noting that in this case there is a problem of ensuring constant and highquality monitoring of the state of the oil product pipeline-branch pipeline system, for which constant monitoring methods based on mathematical modeling are often used to solve, which make it possible to investigate the integrity without changing the pumping mode. However, in order to improve the accuracy of these methods, it is necessary to constantly improve existing or develop new mathematical models of pipeline systems.The main aim of the research. Improvement of mathematical modeling methods for detecting leaks or unauthorized tie-ins during intermediate scheduled discharges of hydrocarbons on the linear part of the main pipeline.Mathematical modeling of the operating mode of the technological section of the main pipeline, taking into account the discharge on the linear part, the need to regulate the operating modes of pumping stations.An algorithm has been developed to determine the location of a leak or illegal tie-in on a trunk pipeline with an intermediate branch to a local oil depot. A graph of the hydraulic slope line is constructed in the presence of damage to the integrity of the pipeline. A preliminary economic assessment of the damage to the supplier company from the loss of the pumped product was carried out.
Economías criminales, extractivismo y acumulación entrelazada: un análisis multiescalar de los nuevos escenarios latinoamericanos
Authors: Terán-Mantovani Emiliano , Scarpacci Martin
Published: February 2024

Este artículo examina los nuevos escenarios, formatos y dimensiones de la criminalidad en el extractivismo en América Latina, desde una perspectiva crítica, con una combinación de economía/ecología política. Se presenta un análisis de las dinámicas de entrelazamiento que se producen entre las vertientes legales/formales, las políticas de despojo que se impulsan desde las esferas de poder y las economías ilícitas/criminales. Este prisma permite poner de relieve el peso de dichas economías en la composición del extractivismo, así como analizar la evolución y el desarrollo de las dinámicas de acumulación legales/ilegales a lo largo del proceso histórico latinoamericano. En este sentido, el artículo resalta brevemente la historicidad de dicha relación para, más adelante, examinar características y tendencias de la actual economía/ecología política del extractivismo.  Desde un análisis multiescalar observamos tres niveles complementarios: a) Extracciones ilícitas/criminales de recursos de la naturaleza, b) Flujos ilícitos entrelazados de commodities y c) Nuevas estatalidades y gobernanzas híbridas. Se resaltan los ocultamientos hibridaciones que, desde ámbitos financieros, fiscales, logísticos, empresariales y estatales, posibilitan y fortalecen estas extracciones violentas y los flujos ilícitos de recursos de la naturaleza. A su vez, el análisis persigue ampliar y robustecer las conceptualizaciones sobre extractivismo.
Translating Educational and Cultural Literacy Works under Berne, Ius Cogens, and Linguistic Genocide
Authors: Beiter Klaus D
Published: February 2024

The lack of works for educational and cultural literacy purposes in their own languages threatens the cultural survival of many vulnerable minority and indigenous groups worldwide. Translation could satisfy related access needs. A strict reading of international copyright law, however, does not facilitate the translation of works into other languages. Yet, it is often forgotten that, in accordance with the integration rule of treaty interpretation, the Berne Convention, and other relevant international intellectual property instruments, would have to be read in the light of internationally protected linguistic human rights in education and for cultural literacy. This mechanism could go some way towards assisting the easier translation of (parts of) works for the stated purposes into other languages. The argument made in this article, however, is that a harmonious reading of existing international copyright law with international human rights law cannot go as far as to sufficiently resolve the access needs of vulnerable groups speaking an endangered language, insofar as translated texts are concerned. In fact, it is contended that the existing regulation of translation under international copyright law is so inimical to the survival of vulnerable groups and their languages that it must be held to promote cultural or linguistic genocide. For that reason, the relevant copyright rules must be considered to conflict with ius cogens, that is, peremptory norms of international law, and to be void in their application to neglected languages. The article makes suggestions as to how countries could design national copyright law regulating translation rights and limitations and exceptions in a way that facilitates translation generally, and into neglected languages specifically. These suggestions are based on a reappraisal of the true character of translation, which must be seen to be highly transformative in nature and resulting in the creation of autonomous new works.
Music Education in Early Childhood Education: Influence of the General Education Law on current regulations
Authors: LÓPEZ-MELGAREJO Alba-maría , LÓPEZ-NÚÑEZ Norberto , MONTOYA-RUBİO Juan Carlos
Published: February 2024

This study aims to analyze the evolution of the Musical Curriculum for the second cycle of Early Childhood Education in Spain from a historical perspective. Methodologically, a review and analysis of the legislative documents on Early Childhood Education from the end of the 19th century to the present has been carried out. To this end, a comprehensive review of the main legislative contributions in this context is carried out. The results reveal that since the 1980s to the present, there has been a trend toward a greater number of curricular elements in relation to the area of Music and, in addition, with respect to the different musical fields, it is seen that they too have undergone a progressive increase over time. The inclusion of the musical language within the area of Artistic Education is a premise that has remained present in all documents. The level of concretion of the normative text is discussed, which has been decreasing over time, contributing to greater freedom for the teacher when considering teaching practice in the classroom. The study of past references is considered necessary to adequately shape the new regulations, especially in a context such as Spain, characterized by constant change in the educational field.
Socioeconomic Status of Immigrant Students in the Context of Teachers' Views
Authors: AKYÜREK Muhammet İbrahim , AKKOYUN Murat
Published: February 2024

The aim of this study is to determine the socioeconomic status of immigrant students in line with the views of teachers working in schools. The study is a phenomenology research based on qualitative research method. The study group of the research consists of 20 teachers working in the secondary schools in the central districts (Karatay, Meram and Selçuklu) in Konya, Türkiye, in the 2022-2023 academic year. A semi-structured interview form was used as a data collection tool in the study. The collected data were analysed by descriptive analysis method. As a result of the analysis of the teachers' views on the current socioeconomic status of immigrant students, problem areas such as social life, communication, economic life, and family life were determined. The problems and conditions encountered in the country of origin pose serious challenges to migrant students and families in every aspect. When these problems are considered as a whole, they disadvantage migrant children in the country of migration. In order to minimize or eliminate these problem areas and to solve them, some practices can be implemented to enhance the language, culture, economic situation of immigrant students and the welfare of their families. Conducting research by referring to the opinions of students and parents in different provinces and levels will contribute to an in-depth and detailed understanding of the socioeconomic status of immigrant students.
Assessment of Motor Fitness Metrics among Athletes in Different Sports: An Original Research
Authors: Reza Md. Nasim , Rahman Md. Hamidur , Islam Muhammad Shahidul , Mola Dessalegn Wase , Andrabi Syed Murtaza Hussain
Published: February 2024

Background. Motor fitness is one of the keys to athletes’ success and is the initial factor mixed with game-specific technique and tactics that has an impact on game performance. All athletes should incorporate these elements into their sport and game actions.
Study purpose. The aim of this study was to evaluate differences in motor fitness metrics among university-level male athletes participating in various sports.
Materials and methods. Sixty (60) male athletes, ranging in age from 18 to 25 years, were selected from six different sports: Athletics, Basketball, Cricket, Football, Handball, and Volleyball. Each group consisted of 10 athletes who had competed at the inter-university level. The research focused on six key fitness metrics: agility, speed, power, arm strength, abdominal muscle strength, and cardiovascular endurance. Appropriate testing methods and instruments were used to measure these parameters. Statistical analysis, including one-way ANOVA and post hoc LSD tests, was performed to identify significant differences between the groups. A significance level of 0.05 was set for the study.
Results. The results showed statistically significant differences among the groups in agility (F(5,54) = 4.776, p<0.001), speed (F(5,54) = 5.602, p<0.000), and cardiovascular endurance (F(5,54) = 3.578, p<0.007). However, no significant differences were observed for power (F(5,54) = 2.079, p>0.082), arm strength (F(5,54) = 1.368, p>0.251), and abdominal muscle strength (F(5,54) = 1.947, p>0.102). According to the post hoc (LSD) test findings, each group’s agility, speed, and cardiovascular endurance parameters were compared to each other to check the significance level.
Conclusions. In summary, the study has revealed that agility, speed, and cardiovascular endurance were significantly different among athletes in various sports, whereas power, arm strength, and abdominal muscle strength were not. The findings suggest that athletes and coaches should prioritize sport-specific fitness components to improve game performance.
Interaction of Skating Agility Tests and Postural Stability in Hockey Players
Authors: Broďáni Jaroslav , Guzman Matúš , Vala Roman , Huszár Viktor
Published: February 2024

Study purpose. In this work, we point out the interaction of complex postural stability (CPS) and skating agility tests among pupils in the hockey club HK Nové Zámky. We determined postural stability using the SEBT and agility with skating tests. We expected a significant interaction between performance in skating agility tests and CPS for both standing legs, which was most closely identified with the eight-item SEBT test.
Materials and methods. The level of CPS was characterized by descriptive statistics. Laterality between right and left standing leg was assessed by t-test and Cohen’s “d”. The relationships between CPS and skating agility tests were determined by Pearson’s correlation coefficient “r”. Predictors were selected by stepwise regression. Statistical significance of differences and relationships was assessed at the 5% significance level.
Results. The results showed no differences in the laterality of the CPS between the right and left standing leg. Correlation analysis demonstrated the interactions of the left and right standing leg with all skating agility tests. Stepwise regression was used to select the tests that were most identified with the performance on the eight-item SEBT test in terms of their skating expression. The Illinois test has the most significant informational power for CPS.
Conclusions. The presence of positive interactions between skating agility and CPS in hockey players point to the importance of a balanced and stable stance of both legs in all directions. The perfect balance and stability of hockey players eliminates the fluctuations caused by skating movement in all directions and facilitates their execution without major changes in dynamic performance. The chance of shortening the activation time of the muscle chains involved in the technique of performing the test also increases significantly, or in the very structure of technique – the economics of ice hockey players’ skating.
School Strategies on Improving Students’ Physical Activity Engagement During COVID-19 Pandemic Period: A Thematic Review
Authors: Piores Victor Fello , Dev Roxana Dev Omar , Muhamad Mohd Mokhtar , Puad Mohd Kari Dharatun Nissa Binti
Published: February 2024

Study purpose. Physical inactivity among school students was an existing health issue over the past decade. This became more alarming when the world was hit by the COVID–19 pandemic. Movement restriction that results temporary school closure significantly affect students’ physical activity participation. Therefore, strategies and practices to improve active play engagement as well as to counteract its negative health-related effects on students were widely implemented by teachers and administrators in school upon its re-opening. Numerous articles have been published on the effectiveness of school-based interventions during the COVID-19 pandemic, but there is still a lack of a review paper that deals with the identification of patterns and trends about school practices in this area. Hence, this paper intends to generate impressions and identify concepts within the published articles during 2021 to 2023.
Materials and methods. Selected articles for this study were collected from the following databases: SCOPUS, Sage, ProQuest, Academic Search complete, Science Direct. Computer-assisted qualitative data analysis (ATLAS ti. 23) guided the comprehensiveness of this review. Study findings were generated and presented through quantitative and qualitative lenses.
Results. Four central themes were identified: 1) Alternative Physical Education – modifying traditional physical education subject; 2) Physical literacy focus – approach anchored to multi-dimensional foundation in physical activity engagement 3) Web-based intervention – virtual and cyberspace approach and 4) Needs–based intervention – focusing on integration of participants’ attributes and specifically designed program.
Conclusions. The structure of strategies conducted by schools were greatly affected by the current community health status. Findings of this study will serve as a reference for designing future intervention approach to address the sedentary lifestyles of young populations associated to specific community health and other related issues.
Performance Evaluation of Biomedical Time Series Transformation Methods for Classification Tasks
Authors:   Universidad Nacional Autónoma de México, Ku-Maldonado Carlos Alejandro , Molino-Minero-Re Erik ,   Universidad Nacional Autónoma de México
Published: February 2024

The extraction of time series features is essential across various fields, yet it remains a challenging endeavor. Therefore, it's crucial to identify appropriate methods capable of extracting pertinent information that can significantly enhance classification performance. Among these methods are those that translate time series into different domains. This study investigates three distinct time series transformation approaches for addressing time series classification challenges within biomedical data. The first method involves a response vector transformation, while the other two employ image transformation techniques: RandOm Convolutional KErnel Transform (ROCKET), Gramian Angular Fields, and Markov Transition Fields. These transformation methods were applied to five biomedical datasets, exploring various format configurations to ascertain the optimal representation technique and configuration for input, which in turn improves classification performance. Evaluations were conducted on the effectiveness of these methods in conjunction with two classification algorithms. The outcomes underscore the significance of these time series transformation techniques as facilitators for enhanced classification algorithms documented in current literature.
Cold dispase digestion of murine lungs improves recovery and culture of airway epithelial cells v2
Authors: not provided piotr.janas , Chauché Caroline
Published: February 2024

Airway epithelial cells (AECs) play a key role in maintaining lung homeostasis, epithelium regeneration and the initiation of pulmonary immune responses. To isolate and study murine AECs investigators have classically used short and hot (1h 37°C) digestion protocols. Here, we present a workflow for efficient AECs isolation and culture, utilizing long and cold (20h 4°C) dispase II digestion of murine lungs. This protocol yields a greater number of viable AECs compared to an established 1h 37°C dispase II digestion. Using a combination of flow cytometry and immunofluorescent microscopy, we demonstrate that compared to the established method, the cold digestion allows for recovery of a 3-fold higher number of CD45-CD31-EpCAM+ cells from murine lungs. Their viability is increased compared to established protocols, they can be isolated in larger numbers by magnetic-activated cell sorting (MACS), and they result in greater numbers of distal airway stem cell (DASC) KRT5+p63+ colonies in vitro. Our findings demonstrate that temperature and duration of murine lung enzymatic digestion have a considerable impact on AEC yield, viability, and ability to form colonies in vitro. We believe this workflow will be helpful for studying lung AECs and their role in the biology of lung. Thelast stepin this version contains a supplemental video with extra context and tips, as part of the protocols.io Spotlight series, featuring conversations with protocol authors.
Significance of Negaraku as a National Symbol: A Review of National Identity Concept
Authors: Shieakh Malik Siti Nurkhalilah Liana , Zainuddin Azizan , Mahmood Anida
Published: February 2024

The existence of national symbols plays a crucial role in reflecting the identity of a nation. The national anthem is one of the national symbol categories that are commonly used by every nation in this world. The combination of syntactic (musical) and semantic (lyrical) structure make it unique from any other national symbols. Despite of tangibility of other national symbols, the national anthem is intangible, and the lack of transient makes it stronger towards the emotional attachment. Negaraku also faces the same problem as there is a lack of understanding regarding the significance of the national anthem as a symbol of national identity. The continuous issues of contempt regarding Negaraku from 1957 until 2022 show the lack of understanding of the anthem itself as a symbol of national identity. Therefore, this paper aims to emphasize the significance of Negaraku as a symbol of national identity as a foundation of knowledge for fellow citizens about Malaysia. An integrative literature review is used to analyze the significance of Negaraku towards national identity discussion. The analysis will review various sources of relevant information from international and local references which cover books, journals, websites as well as newspaper cutting. Based on the analysis drawn it proves that Negaraku textual structures indicate a direct interpretation of national identity through historical and cultural elements in political and economic perspectives. In conclusion, the conceptual discussion through Negaraku contextual analysis can widen the social sciences area through anthemology studies in Malaysia.
Factors Influencing Users’ Satisfaction with Online Agricultural Products in China’s First and Second-Tier Cities Under the Epidemic
Authors: Wu Xingyuan , Idris Aida , Bukhari Nur Jannah
Published: February 2024

The Covid-19 crisis brought with it significant changes to human lives including changes to behaviour. Particularly, the Coronavirus lockdowns and other restrictions contributed to the rise of online shopping for agricultural products in China’s first and second-tier cities. The core aim of the investigation is to evaluate the factors that influence the satisfaction of users with online agricultural products in first and second-tier cities in China during the pandemic. The research methodology is qualitative and relies on interpretivism to examine the experiences regarding the satisfaction of users with online agricultural products in first and second- tier cities in China during the crisis. An inductive approach is applied and the specific data collection instrument in this research entails semi-structured interviews to facilitate a comprehensive inquiry and gain rich insights. Semi-structured interview sessions are conducted with 30 participants including Chinese shoppers who used online agricultural products between 2019 and 2022 just before the Covid-19 crisis or during the pandemic. The research findings indicate that optimism was found to be crucial to the increased consumption of online agricultural products and high quality emerged as the most influential factor behind users’ satisfaction with online agricultural products. However, online agricultural product sellers in China need to ensure excellence in their operations to succeed in the competitive online marketplace. Conclusively, this investigation achieved its overarching aim of evaluating the factors that influence the satisfaction of users with online agricultural products in first and second-tier cities in China during the pandemic.