bluuebunny/crossref_metadata_2025 huggingface dataset:
WORLD HEALTH ORGANIZATION DRUG PRESCRIBING INDICATORS AT A UNIVERSITY PRIMARY HEALTH-CARE CENTER IN OMAN
Authors: AL-RUBKHI SS  , AL-HINAI M  , AL-GHAFRI F  , AL BALUSHI KA
Published: February 2020

Objective: This study aimed at evaluating the prescribing patterns of drugs based on the World Health Organization (WHO) indicators at the primary health-care Family Medicine and Community Health Clinic in Sultan Qaboos University Hospital, Oman.
Methods: This was a retrospective cross-sectional study covering a 6-month period in 2016 (January–June) for all patients attended Family Medicine and Community Health Clinic in Sultan Qaboos University Hospital, Oman. Data of 300 patients with 892 prescriptions were assessed during the study period.
Results: The average number of drugs per encounter (2.82), the percentage of encounters with antibiotics (13.3%), and the percentage of encounters with an injection (7.6%) were within the optimal range set by the WHO. The percentage of drugs prescribed by generic name (80.1%) and the percentage of drugs prescribed from an essential drug list (EDL) (40.4%) did not reach the optimal 100% value set by the WHO.
Conclusion: Most of the WHO core prescribing indicators in the study were within the optimal range. Prescribing from the WHO EDL was sub-optimal. These data will set ground to optimize rational drug prescribing in the primary health-care setting.
PHYTOCHEMICAL SCREENING, GAS CHROMATOGRAPHY–MASS SPECTROMETRY PROFILING, IN VITRO CYTOTOXICITY, AND ANTHELMINTIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF DURANTA ERECTA LEAVES
Authors: R RAJESWARI , PRABHAKARAN V  , SARAVANAKUMAR A
Published: February 2020

Objective: The present study aims at the preliminary phytochemical evaluation, gas chromatography–mass spectrometry (GC–MS) analysis, in vitro cytotoxicity, and anthelmintic activity of the hydroalcoholic extract of D. erecta leaves.

Methods: The hydroalcoholic extraction of the plant material is done with Soxhlet apparatus and the GC–MS profiling of the extract is performed. The in vitro cytotoxicity activity of the extract is done using the MOLT-3 cell lines. The anthelmintic activity is performed using Pheretima posthuma.

Results: The GC–MS analysis shows the presence of various secondary metabolites with proved pharmacological activity. The in vitro cytotoxicity and the anthelmintic activity of the extract show the beneficial effect of the plant.

Conclusion: The flavonoids, phenolic compounds, and tannins present in the plant extract may support the cytotoxic and anthelmintic activity of the plant.
DESIGN, SYNTHESIS, DOCKING, ANTITUMOR SCREENING, AND ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION PREDICTION OF NEW HESPERDIN DERIVATIVE
Authors: AL-SHMGANI HANADY S , RAIED MUSTAFA SHAKIR  , AHMED W NASER  , ELEKOFEHINTI OLUSOLA OLALEKAN
Published: February 2020

Objective: Hesperidin (HSP) is a pharmacologically active organic compound found in citrus fruits and peppermint. We synthesized a new HSP derivative by reacting it with 5-Amino-1,3,4-thiadiazole-2-thiol in acetic acid.

Methods: This compound was characterized by Fourier-transform infrared, proton nuclear magnetic resonance, and electron impact mass spectra. A molecular docking study explores the predicted binding of the compound and its possible mode of action. Bioavailability, site of absorption, drug mimic, and topological polar surface was predicted using absorption, distribution, metabolism, and excretion (ADME) studies.

Results: The docking study predicts that the new compound binds to the active sites of Aurora-B and the MST3 pocket and has good ADME properties. Moreover, the thiazole ring and the presence of the electron releasing groups and hydrogen bond interaction with amino acid residues within the active sites play an important role in enhancing the antioxidant activity.

Conclusion: In the present study, a new HSP derivative has been synthesized and characterized successfully and a theoretically promising antioxidant and anticytotoxic active agent introduced. We have shown the detailed binding analysis of 1,3,4-thiadiazol and hydrogen bonds with the inhibitor binding cavity of Aurora B and MST3. This could provide the development of some effective compounds against different diseases.
IN VITRO ANALYSIS OF ANTICANCER POTENTIAL OF TRIGONELLA FOENUM-GRAECUM
Authors: SINGH SHIVSHARAN , SATISH K VERMA  , SANTOSH SINGH
Published: February 2020

Objective: The recent work was carried out to evaluate the presence of bioactive compounds and anticancer activities of selected plant Trigonella foenum-graecum extract.

Methods: The crude extraction of whole plant was carried out using petroleum ether as a solvent by cold percolation as well as hot percolation method (Soxhlet method) both. The presence of phytochemicals was determined using standard protocols. The anticancer activities were evaluated by sulforhodamine B (SRB) dye assay method using Mitomycin-C (anticancer drug) as a positive control.

Results: The qualitative analysis of plant extract showed the presence of bioactive compounds, namely, protein, alkaloids, steroids, phenolics, and flavonoids. The plant extract was tested for in vitro anticancer activity against human liver cancer (HEP-2) and colon cancer (HT-29) cell lines using SRB assay. The plant extract showed significant results against HT-29 and HEP-2 cancer cell lines.

Conclusion: The study concluded that the extract of T. foenum-graecum can be further carefully used in herbal formulations for cancer therapy.
DEVELOPMENT OF ANALYTICAL METHOD FOR IMATINIB MESYLATE BY ULTRAVIOLET SPECTROSCOPY
Authors: AJITHKUMAR P  , ANTON SMITH A
Published: February 2020

Objective: A simple, selective, sensitive, specific, and spectrophotometric method has been developed for the detection of imatinib mesylate in pure form and formulations.

Methods: The analytical condition was optimized for the drug, carried out as per the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines.

Results: The drug shows absorption at 232.0 nm and obeyed beers law in the wide concentration range from 0.5 to 4.0 μg/ml. The lower limit of detection was found to be 0.331 μg/ml and the limit of quantification to be 1.004 μg/ml. The regression equation was found to be y = 0.08x. The precision of the method was found to be 99.04%±0.527% and the percentage of drug recovered by this method is 100.13%±1.375%.

Conclusion: The method is simple and suitable for determination for imatinib mesylate in pure and pharmaceutical preparation.
CARDIOVASCULAR DISEASES ASSOCIATED WITH PSEUDOEXFOLIATION SYNDROME – A PROSPECTIVE CROSS-SECTIONAL STUDY
Authors: CHELLAKUMAR VIKRAM , RASHMI PRIYANKA  , BALAKRISHNAN M
Published: February 2020

Objectives: In recent years, pseudoexfoliation syndrome (PXF) is recognized as a systemic disorder and as an independent risk factor for cardiovascular diseases including hypertension, angina, myocardial infarction, and stroke. We studied the prevalence of cardiovascular diseases associated in patients with PXF.

Methods: It was a prospective cross-sectional study done over a period of 2 years from January 2017 to December 2018 at the Department of Ophthalmology in Sree Balaji Medical College and Hospital. A total of 100 patients with PXF both male and female above the age of 50 were included in the study. They were given a standard questionnaire to evaluate common cyclic vomiting syndrome symptoms and a history of angina, myocardial infarction, and cerebrovascular accident was noted. All patients underwent blood pressure (BP) measurement and electrocardiogram (ECG) recording.

Results: In our study which included 100 patients with PXF there were 57 male patients and 43 female patients. Most of the patients (59%) were above 65 years of age and 36 patients were diagnosed with open-angle glaucoma. A total of 62 patients had persistently elevated BP on three different occasions. Only five patients gave a positive history of angina at some point in their lives and among them, only four patients showed demonstrable changes in ECG. One patient gave a history of myocardial infarction (two showed changes in ECG) and none of the patients had cerebrovascular accidents.

Conclusion: Our study showed that more than 60% of patients with PXF had hypertension; however, a statistically significant association with other conditions was not noted.
Historia de la sexualidad IV
Authors: Ramírez García Víctor Hugo
Published: February 2020

Reseña de Historia de la sexualidad iv
ARTivismo político y teoría queer: hacia una politización de la autobiografía femenina
Authors: Scerbo Rosita
Published: February 2020

El objetivo de la teoría queer es desafiar la normalidad y no exclusivamente la heterosexualidad. Los intereses de la teoría queer se extienden a una deconstrucción más general de la ontología social contemporánea y nacen a partir de estructuras y etiquetas impuestas por la cultura dominante. Mi estudio analiza el arte visual de carácter autobiográfico de la fotógrafa argentina Gabriela Liffschitz y de la artista chicana Laura Aguilar. Ambas están parodiando la mirada masculina y desafiando sus expectativas con sus proyectos fotográficos. Al hacerlo, Liffschitz interrumpe la convención visual del pecho femenino visto como un objeto sexual para la apropiación y el placer masculino, y Aguilar hace lo mismo al revalorar el cuerpo femenino obeso. Intento demostrar los beneficios del uso del término queer en todo su potencial sin restringir su ámbito de investigación.
Feminismo/s. Entre el sincretismo y la paradoja
Authors: Arbuet Osuna Camila
Published: February 2020

El presente artículo se propone analizar las implicaciones políticas del carácter heterogéneo del/los feminismo/s. Esto supone las estrategias de expansión y crítica que componen su actual vitalidad, observando cómo su estructura paradojal convive con significativas capacidades sincréticas. Iniciaremos la discusión partiendo del debate sobre si el feminismo es uno o varios para pasar a indagar cómo estas tensiones entre lo uno y lo múltiple minan sus estrategias internas. Para ello nos detendremos en la plataforma “Para un feminismo ganador” del partido español Podemos y en ciertas peculiaridades cardinales del vínculo entre lo queer y el feminismo. Finalmente, como parte del mismo problema, observaremos las novedades que el instrumento del Paro Internacional de Mujeres propone en tanto experiencia masiva en 2017 y 2018. A lo largo del texto, las reflexiones serán acompañadas por el análisis de escenas actuales del/los feminismo/s argentino/s.
Recursos intangibles revelados a través del mercado de valores de Panamá
Authors: Herrera Rodríguez Edila Eudimia , Ordóñez-Castaño Iván Andrés
Published: February 2020

Este artículo analiza los recursos intangibles revelados por parte de las empresas que cotizan en el mercado de valores de Panamá. Se estudian los factores que pudieran explicar la revelación de estos recursos. La necesidad de mayor transparencia por parte de las empresas cotizadas en este mercado bursátil es creciente, sobre todo por las propias presiones del mercado en el sentido del valor que pudiera ser percibido con la divulgación de estos recursos. El estudio se realiza desde las perspectivas de la teoría de agencia, la señalización y coste del propietario. Se analizó una muestra de 61 empresas, donde se utilizó un índice con 145 indicadores para medir la revelación de los recursos intangibles. Estos están distribuidos en cinco categorías de capital: humano, estructural tecnológico, estructural organizativo, relacional del negocio y relacional social. Cada indicador representa un recurso intangible de la organización y con ellos se desarrollaron modelos para medir la probabilidad de revelación de información de capital humano y capital relacional, componentes del capital intelectual. Los resultados indican que, para las empresas con mayores volúmenes de activos, rentabilidad operacional, nivel de endeudamiento y tiempo en el mercado, la probabilidad de revelación de sus recursos intangibles aumenta.
Crítica a las propiedades psicométricas de una escala de medición de factores de riesgo psicosocial propuesta en la NOM 035 de la STPS en México
Authors: Uribe Prado Jesús Felipe , Gutiérrez Amador Julia Chantal , Amézquita Pino Jorge Antonio
Published: February 2020

El propósito de este estudio fue mostrar en forma crítica y propositiva las propiedades psicométricas de la escala de “Identificación de los factores de riesgo psicosocial y evaluación del entorno organizacional” propuesta por la STPS (2017) para más de 50 trabajadores de la NOM 035 con una muestra de trabajadores estratificada por género de la Ciudad de México y del interior de la república de una empresa de servicios (n=114). El estudio consistió primero, en obtener indicadores de tendencia central y de dispersión del cuestionario por reactivo, así como su fiabilidad de Cronbach (entre .67 y .93); posteriormente se llevaron a cabo análisis factoriales confirmatorios (AFC) con ecuaciones estructurales (IBM-AMOS) para validez; y finalmente, se realizaron correlaciones Pearson y análisis de varianza One Way para conocer algunas relaciones de manera descriptiva.  Los resultados mostraron que el instrumento de la STPS cuenta con muy buena confiabilidad, sin embargo, los AFC no mostraron propiedades de validez para ajustes y calificación, por lo que se recomienda a la STPS considerar para futuros estudios las siguientes recomendaciones: hacer discriminación de reactivos, agregar algunos ítems, incrementar la muestra a 10 sujetos por ítem, analizar también por componentes principales y con factoriales de segundo orden, entre otros. Se observaron relaciones entre género, jerarquía de puesto y estado civil con algunos dominios específicos. La contribución de este estudio es importante para la difusión de la NOM 035 por parte de la STPS, el uso confiable del cuestionario por parte de empresas, sindicatos y para investigación académica, así como para fines de diagnóstico, evaluación e intervención a partir del conocimiento de los factores de riesgo psicosocial estudiados.
Cultura organizacional e innovación en la orientación al mercado de empresas familiares de Pasto (Colombia)
Authors: Solarte Solarte Claudia Magali , Solarte Solarte Martha Lida , Barahona Vinasco José Fernando
Published: February 2020

El propósito de la investigación fue medir la cultura organizacional con la Adeterminación de la capacidad  de innovación y reconocimiento del nivel de orientación al mercado que presentan las empresas de familia de la ciudad de San Juan de Pasto (Departamento de Nariño, Colombia).   Se trabajó con una muestra de 234 personas entre gerentes, fundadores y dueños de empresa de familia. Como metodología se acogió un enfoque cuantitativo, método empírico-analítico y el tipo de investigación explicativo.  Así, los resultados evidenciaron que la innovación determina en mayor medida a la orientación al mercado que la cultura organizacional de la empresa; la orientación al mercado es la variable que más causalidad presenta sobre la variable innovación.  Una conclusión relevante fue que a medida que la empresa incluye en su producción algún tipo de innovación, la orientación al mercado crece en una magnitud en específico, es decir, las dos variables están estrechamente relacionadas y mantienen una correlación positiva.
Dividend payout policy, family control, and institutional investors in an emerging country: The case of Mexico
Authors: Valencia Herrera Humberto , Ruiz Rivera Felipe Javier
Published: February 2020

The dividend payout ratio and its volatility in firms listed on the Mexican Stock Exchange from the second quarter of 2009 to the first quarter of 2013 relate to corporate governance aspects. A structural equations model found that institutional investors avoid firms with high family intervention and prefer market risk despite greater volatility in dividend payouts. Similarly, the dividend payout volatility and market risk are positively related. Moreover, dividend payout is smaller in firms with high family intervention in management. Companies with a strong family control smooth their dividend payout and have a smaller number of institutional investors.
Drivers of technological capability in Mexico: The mesoeconomic factors that impulse the techno-scientific products
Authors: Pérez Hernández Carla Carolina
Published: February 2020

The aim of this paper is to examine the impact of technological inputs and the preconditions for development on the results achieved in terms of technological capacity in Mexico (measured by granted patents, publications and high complexity exports). Consequently, a panel data technique was applied with individual and temporal fixed effects, based on the variables proposed by Cepal (2007) & Hausmann & Nedelkoska (2018), and collecting data from various public sources. From the econometric estimation, it is found that: the imports of highly complex products, education investment, international immigration and the number of researchers are drivers of technological capacity that show the greatest impact for impulse the techno-scientific capability of the region.
ROTAÇÃO DE RETALHO PALATINO COMO ALTERNATIVA DE TRATAMENTO PARA FÍSTULA BUCOSSINUSAL
Authors: Braz Rodrigues Arantes Eugênio
Published: February 2020

ResumoA fístula ou comunicação bucossinusal consiste na formação de um trajeto direto entre a cavidade oral e o seio maxilar diagnosticada tardiamente após epitelização da mucosa formando um canal bucossinusal permanente. Na maioria das vezes, essa complicação ocorre em função da relação anatômica do seio maxilar intimamente relacionado com o ápice das raízes dos dentes superiores posteriores. Procedimentos cirúrgicos inadequados relacionados à exodontia dos elementos dentários envolvidos ou extensa pneumatização do seio maxilar podem ser as causas mais comuns dessa patologia. O objetivo do presente trabalho é apresentar um relato de caso clínico de uma fístula bucossinusal pós exodontia e não corrigida imediatamente, tratada através de retalho mucoso palatino vascularizado e rotacionado para fechamento primário. A técnica do retalho palatino mostrou-se uma opção favorável para o fechamento do defeito sinusal em um único tempo cirúrgico, preservando a mucosa queratinizada e a anatomia do sulco vestibular.Palavras-chave: Seio maxilar, sinusite maxilar, fístula bucoantral, cirurgia bucal.AbstractThe bucosinusal fistula or communication consists in the formation of a direct path between the oral cavity and the maxillary sinus diagnosed late after epithelialization of the mucosa forming a permanent bucosinusal canal. Most often, this complication occurs due to the anatomical relationship of the maxillary sinus closely related to the apex of the roots of the posterior superior teeth. Inadequate surgical procedures related to the extraction of the involved dental elements or extensive pneumatization of the maxillary sinus may be the most common causes of this pathology. The aim of the present study is to present a case report of an immediately uncorrected post-extraction bucosinusal fistula treated with a vascularized palatine mucous flap and rotated for primary closure. The palatal flap technique proved to be a favorable option for closing the sinus defect in a single surgical time, preserving the keratinized mucosa and the buccal sulcus anatomy.Key-words: Maxillary sinus, maxillary sinusitis, oroantral fistula, oral surgery.
USO DE ANCORAGEM ZIGOMÁTICA NA REABILITAÇÃO DE MAXILA ATRÓFICA
Authors: Araújo Pereira Júnior Antônio José
Published: February 2020

RESUMOOs implantes zigomáticos associados ou não aos implantes convencionais surgiram como uma alternativa para a reabilitação de maxila moderada ou severamente reabsorvida. O intuito deste artigo foi relatar um caso de carga imediata em maxila atrófica, ressaltando a importância de uma correta escolha da técnica cirúrgica.ABSTRACTZygomatic implants associated or not with conventional implants have emerged as an alternative for moderately or severely resorbed maxillary rehabilitation. The purpose of this article was to report a case of immediate loading in the atrophic maxilla, emphasizing the importance of a correct choice of the surgical technique.Palavras-chave: Implantes dentários, Maxila, Zigoma.Keywords: Dental implants, Maxilla, Zygoma.
Detection of Transovarial Transmission on Aedes sp. in Gombong Kebumen Central Java
Authors: Wijayanti Siwi Pramatama Mars , Octaviana Devi , Asti Arnika Dwi
Published: February 2020

Abstract. Gombong Subdistrict is one of dengue-endemic area in Kebumen Regency, Central Java. The high number of dengue cases in this area raises the question of whether there has been transovarial transmission occured from the Aedes sp. to their eggs. Transovarial transmission could be dangerous because the next generation of mosquitoes can directly become competent vectors as transmitters of the dengue virus (DENV). The purpose of this study is to detect dengue virus transovarial transmission in Aedes sp. in Gombong Subdistrict. This is a descriptive research in Gombong, Semanding, and Kali Tengah villages, Gombong Sub District. A total of 300 houses, 100 houses from each village were selected in this study. There were 600 Oviposition traps (ovitraps) were installed both inside and outside of houses for 6 days. Ovitraps were calculated by its Ovitrap Index (OI). Detection of transovarial transmission was carried by rearing field mosquitoes to Filial 1 then identified by RT-PCR assay. This study showed that OI in the three villages was higher in outdoor compared to indoor positions. All tested samples were negative DENV, indicated that there were no transovarial transmission occured at the study sites. Transmission in these study areas might still through horizontal mechanism transmission by mosquito bites. Although there is no transovarial transmission, awareness of dengue transmission must be continued by eradicating of mosquito nests such as 3M plus activities on a regular basis
Utilização de Dispositivos Móveis por Idosos de um Programa de Extensão Universitária
Authors: Maria Mendes Rodrigues Pereira Sandra , Cardoso de Castro Berry Maria , Fátima G. Menezes Maria , Isabel de Castro de Souza Maria
Published: February 2020

O objetivo desse estudo foi identificar o uso de dispositivos móveis em idosos de um programa de extensão universitária. Trata-se de um estudo quantitativo descritivo de uma amostra de 50 idosos entrevistados presencialmente no “Programa Interdisciplinar de Saúde e Qualidade de Vida do Idoso”. Os resultados mostraram que 86% utilizam celular; 60% usam aplicativos móveis, sendo que destes, todos utilizam o WhatsApp; 56,7% utilizam rede social tipo Facebook e apenas um idoso já baixou um aplicativo sobre Alimentação ou Saúde. Percebe-se assim uma maior utilização de aplicativos voltados para comunicação. Esse estudo mostrou que a maioria dos idosos entrevistados tem celulares com recursos, porém, não os utilizam na amplitude de atividades que poderiam ser realizadas.
NativoApp: Realidade aumentada aplicada no resgate cultural da Língua Wai-Wai
Authors: Silva de Farias Wilder , Pereira do Nascimento Roberto , José Moutinho da Ponte Marcio , Lobato Nattan , Rodrigues Reis Josivan
Published: February 2020

Devido às constantes mudanças socioambientais que ocorrem na região amazônica aliada ao avanço tecnológico, povos indígenas outrora isolados agora convivem com os costumes contemporâneos e lutam para não verem sua cultura desaparecer e evitar que jovens, aldeados ou não, acabem deixando de lado seus costumes e tradições dado o contato com a cultura urbana. Além disso enfrentam diversas dificuldades na transmissão do conhecimento para as novas gerações bem como no processo educacional e nesse contexto, este trabalho busca por meio de  um aplicativo de realidade aumentada promover o resgate cultural e a facilitar o processo de ensino e aprendizagem de crianças e jovens indígenas, transmitindo de forma intuitiva os costumes e língua indígena Wai-Wai.
Apresentação de Recomendações em Ambientes Educacionais
Authors: Da Silva de Souza Ediana , Gasparini Isabela , Medeiros Machado Guilherme
Published: February 2020

Há um crescente corpo de literatura no campo dos sistemas de recomendação que focam na melhoria da precisão. No entanto, é necessário pensar na forma de apresentar recomendações, a fim de fazer com que os usuários entendam os motivos pelos quais estas foram geradas, bem como apresentar a recomendação na interface de maneira satisfatória. Em ambientes educacionais isso se torna ainda mais importante, visto que pode influenciar no processo de ensino e aprendizagem. Desta forma, este trabalho investigou como a comunidade de inform´atica na educação tem projetado a apresentação das recomendações. Como resultado, percebe-se que o tema ainda é pouco explorado e que o foco dos projetos de sistema de recomendação educacionais permanece no algoritmo recomendador.
O Mestrado Profissional em Informática na Educação do IFRS: Temas de Pesquisa, Objetos de Investigação e Produtos Privilegiados
Authors: Silveira Diogo de Ávila Fontoura Julian , Carolina Soares Ramos Procasko Josiane
Published: February 2020

O estudo aqui apresentado busca identificar, a partir das dissertações produzidas junto ao Mestrado Profissional em Informática na Educação do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul (IFRS), os temas de estudo presentes nas investigações, os objetos de pesquisa privilegiados e os “produtos” desenvolvidos junto à produção acadêmica do curso. Para isto, nos utilizamos – como estratégia metodológica – dos “princípios” de Estado de Conhecimento, caracterizados pelo foco na pesquisa de caráter histórico-bibliográfico, exploratório-investigativo, inventariante e descritivo. O corpus de análise se apresenta a partir das 21 dissertações produzidas pelas 2 (duas) primeiras turmas do curso. Os resultados desta investigação apontam para a complexidade e diversidade presente junto aos estudos do campo da Informática na Educação, especialmente, quando articulados a Educação Profissional, Científica e Tecnológica. No Mestrado Profissional em Informática na Educação do IFRS, destacam-se temas relacionados as “tecnologias e as aprendizagens”; nos objetos de pesquisa percebemos uma predileção as “práticas pedagógicas” no ambiente escolar; e como produtos fruto destas investigações, evidenciamos uma relação direta com o desenvolvimento de “matrizes e protocolos” de ação para o campo educacional.
PENSAMENTO COMPUTACIONAL NO ENSINO MÉDIO: PRÁTICAS MEDIADORAS UTILIZANDO A LINGUAGEM SCRATCH
Authors: Poloni Leonardo , Maria do Sacramento Soares Eliana , G. Webber Carine
Published: February 2020

pensamento computacional envolve habilidades que procuram aprofundar o conhecimento e as capacidades dos estudantes. Apresenta-se, neste artigo, um estudo cujo foco foi identificar formas de mediação possibilitadas pela linguagem Scratch no processo de ensino-aprendizagem de programação. O quadro teórico baseou-se na teoria sociointeracionista de Vigotski. O percurso metodológico foi delineado por um estudo de caso, baseado em uma oficina de programação. O resultado permitiu inferir que o ambiente Scratch tem potencial para mediar o aprendizado de programação. Contudo, o professor precisa também atuar como mediador criando estratégias e intervenções potenciais para auxiliar o estudante.
Avaliação do Google Sala de Aula como Ferramenta de Apoio ao Processo de Ensino-aprendizagem em um Curso de Licenciatura em Ciências Biológicas Presencial
Authors: Martins Jonatas , Teles Ariel , Viana Davi , José Silva Francisco , Coutinho Luciano , Teixeira Silmar
Published: February 2020

Este artigo apresenta uma investigação sobre a usabilidade do Ambiente Virtual de Aprendizagem (AVA) Google Sala de Aula, visando identificar quais contribuições e melhorias a sua utilização pode trazer para o processo de ensino-aprendizagem. Foi aplicado um questionário, com a participação de 28 alunos em um curso de Licenciatura em Ciências Biológicas. Os resultados demonstram uma maior flexibilidade de acesso pelos alunos às atividades realizadas por meio do AVA e também com o uso de dispositivos móveis, tanto dentro quanto fora da sala de aula. Dessa forma, os resultados sugerem que a ferramenta é de fácil utilização, proporcionando maior interatividade e colaboração através da mediação docente.
Second-derivative spectrophotometry for the analysis of simvastatin in polymeric nanocapsules
Authors: Gomes Patrícia , Negretto Carla M. U. , Naisinger Zanandria B. , Lorenzoni Ricardo , Wingert Nathalie Ribeiro , Raffin Renata P.
Published: February 2020

Conventional spectrophotometry methods are very susceptible to the presence of interferences in complex mixtures such as nanoparticules, requiring prior treatment or extraction of the analyte, and not always providing an adequate response. Derivative spectrophotometry method is capable to eliminate its interference; it is an alternative method for drugs determination in complex matrices. This work investigated the utility of derivate spectrophotometry in assay of simvastatin in polymeric nanocapsules (SIVNC). Shimadzu® UV-1650 double-beam spectrophotometer with 1.0 cm quartz cells was used in this study. The second-order deriva­tive spectrum was obtained employing Δλ=20,000 nm and scaling factor=9.0. The determinations were made at 239 nm (2D239) by zero-crossing method. 2D239 method was validated employing the parameters: specificity, linearity, robustness, precision and accuracy. Results: The specificity test showed there was no interference of constituents commonly found in SIVNC formulation in 2D239. The standard curve showed a correlation coefficient of 0.994. The robustness was evaluated by small changes in the conditions of sample analysis and however, no significant changes were observed regarding drug quantitation. The precision was demonstrated by relative standard deviation (RSD) of intra-day (RSD=1.61-3.76) and inter-day studies (RSD=2.32). The recovery test resulted in an average of 100.66%, which confirmed the accuracy of the method. The procedure was simple and rapid; therefore this technique offers an alternative for determination of SIVNC without interferences.
Active constituents of Koelreuteria paniculata root
Authors: Wang Yacheng , Liu Qimei , Zheng Dongfang , Zhao Yong , Wang Ting , Yan Shuangxi , Gu Haiping
Published: February 2020

In this paper, Koelreuteria paniculata roots was taken as the research object, and its active substances were analyzed. First, Koelreuteria paniculata roots was crushed, dried, extracted, filtered, and concentrated by rotary evaporation. Then, the active substances of Koelreuteria paniculata roots were extracted with ethanol, benzene/ethanol, and methanol. Finally, Koelreuter was detected by GC-MS, FT-IR, TD-GC-MS, and TG analyses. Data analysis revealed that Koelreuteria paniculata roots contains oleic acid, linoleic acid, Lupinol, retinal, and other active substances that are of great value to medical, chemical, and food industries.
Resourcing potential of olive oil pomace
Authors: Li Linbo , Deng Yu , Li Zimeng , Zhang Zanpei , Gao Xinya , Geng Xiaodong , Zhang Dangquan
Published: February 2020

Olive oil is a kind of high-quality edible oil obtained by quick extraction from the fresh olive fruit. It has rich biological activity and positive effect on human health which leads to the increase of the demand for olive oil. Olive pomace is a by-product of olive oil during processing which is also rich in biologically active ingredients. But it is often treated as waste, not only causes environmental pollution but also a great waste of resources. In order to explore the high value utilization of olive oil by-products, the extract components of olive oil pomace by benzene, ethanol and acetone were analyzed by gas chromatography-mass spectrometry. The results showed that there were 109, 70, and 71 components which identified in benzene, ethanol and acetone extracts of olive oil pomade respectively. Many of these components can be resourced in industries of biomedicine, bioenergy, spices, and food additives.
Diverse bioactive components from Ginkgo biloba fruit
Authors: Gao Xinya , Jiao Qiang , Zhou Bingqian , Liu Qimei , Zhang Dangquan
Published: February 2020

The fruit of Ginkgo biloba is widely concerned because of its high economic and medical value. In this study, efficient extraction methods were used to identify the bioactive components in the fruit of Ginkgo biloba. The bioactive constituents of Ginkgo biloba fruit were identified and the uses of these bioactive components were discussed. There are more than 160 kinds of chemical extracts in Ginkgo biloba fruit. It mainly contains flavonoids, terpenes, phenols, alkaloids, polyisopentene, quinine acid, linoleic acid, monoxalic acid, gingol, gingosterone and other substances. It contains a variety of substances, and has many applications in anti-bacterial, anti-tumor, lipid-lowering and other aspects. The results suggested that Ginkgo biloba fruit has great potential in chemical raw materials, biological health care, biomedical treatment, aroma and bioenergy.
Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes
Authors: Maffi Paola , Lundgren Torbjörn , Tufveson Gunnar , Rafael Ehab , Shaw James A.M. , Liew Aaron , Saudek Frantisek , Witkowski Piotr , Golab Karolina , Bertuzzi Federico , Gustafsson Bengt , Daffonchio Luisa , Ruffini Pier Adelchi , Piemonti Lorenzo ,   REP0211 Study Group, Nano Rita , Mercalli Alessia , Lampasona Vito , Magistretti Paola , Sordi Valeria , Antonio Secchi , Antonioli Barbara , Galuzzi Marta , Tosca Marta Cecilia , De Carlis Luciano , Colussi Giacomo , Korsgren Olle , Pollard Helena
Published: February 2020

OBJECTIVE

Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients.

RESEARCH DESIGN AND METHODS

A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition to immunosuppression. Primary outcome was the area under the curve (AUC) for C-peptide during the mixed-meal tolerance test at day 75 ± 5 after the first and day 365 ± 14 after the last transplant. Secondary end points included insulin independence and standard measures of glycemic control.

RESULTS

The intention-to-treat analysis did not show a significant difference in C-peptide AUC at both day 75 (27 on reparixin vs. 18 on placebo, P = 0.99) and day 365 (24 on reparixin vs. 15 on placebo, P = 0.71). There was no statistically significant difference between treatment groups at any time point for any secondary variable. Analysis of patient subsets showed a trend for a higher percentage of subjects retaining insulin independence for 1 year after a single islet infusion in patients receiving reparixin as compared with patients receiving placebo (26.7% vs. 0%, P = 0.09) when antithymocyte globulin was used as induction immunosuppression.

CONCLUSIONS

In this first double-blind randomized trial, islet transplantation data obtained with reparixin do not support a role of CXCR1/2 inhibition in preventing islet inflammation-mediated damage.
ANALISIS KUALITAS BUTIR SOAL TIPE HOTS PADA KOMPETENSI SISTEM REM DI SEKOLAH MENENGAH KEJURUAN
Authors: Warju Warju , Ariyanto Sudirman Rizki , Soeryanto Soeryanto , Trisna Rio Adi
Published: February 2020

Tujuan dari penelitian ini adalah untuk mengetahui kualitas dari soal tipe HOTS pada kompetensi sistem rem melalui pelaksanaan analisis butir soal. Penelitian ini merupakan penelitian evaluatif. Sampel penelitian ini adalah siswa kelas XI TKRO 1 di SMKN 1 Labang Bangkalan sejumlah 32 siswa. Instrumen penelitian ini meliputi soal pilihan ganda tipe HOTS, kunci jawaban, dan lembar jawaban hasil pekerjaan siswa, yang kemudian dianalisis validitas, reliabilitas tingkat kesukaran, daya pembeda, dan efektivitas pengecoh menggunakan bantuan software Anates V4. Hasil penelitian ini menunjukkan bahwa dari total 50 soal pilihan ganda terdapat 80%soal yang masuk dalam kategori valid, sedangkan 20% soal masuk pada kategori tidak valid. Kemudian untuk reliabilitas mendapatkan nilai koefisien sebesar 0,917. Sementara itu soal yang masuk kategori mudah, sedang, dan sukar pada indeks tingkat kesukaran masing-masing sebesar 38%, 46%, dan 16%. Kemudian soal yang masuk kategori baik sekali, baik, cukup, buruk, dan tidak baik pada indeks daya beda masing-masing sebesar 10%, 42%, 28%, 6%, dan 14%. Selanjutnya pada indeks pengecoh soal yang masuk kriteria sangat baik, baik, kurang baik, buruk, dan sangat buruk masing-masing sebesar 28%, 29%, 19%, 17%, dan 7%. Dengan demikian dapat disimpulkan bahwa soal tipe HOTS pada kompetensi sistem rem layak digunakan sebagai alat penilai kompetensi siswa
PERAN PENDIDIKAN AGAMA ISLAM DALAM MEMBENTUK KARAKTER JUJUR PADA SISWA
Authors: Jai Ani Jailani , Rochman Chaerul , Nurmila Nina
Published: February 2020

Penelitian ini dilakukan untuk mengukur sikap kejujuran pada setiap siswa di kelas V Sekolah Dasar SD.S Plus Syania CImanggung. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan kuantitatif. Sample pada penelitian ini adalah siswa kelas V di SD.S Plus Syania Kel. Cihanjuang Kec. Cimanggung Kab. Sumedang Jawabarat. Teknik pengumpulan data menggunakan observasi, ini dilakukan oleh peneliti dengan meninjau langsung kelapangan sebagai objek penelitian untuk memperoleh data, kemudian peneliti memberikan kuesioner. Dari hasil data yang diperoleh jumlah rata-rata sikap kejujuran siswa di kelas V sebesar 80.23, jumlah yang cukup besar yang berarti memberikan kesimpulan bahwa sikap jujur yang dimiliki siswa cukup tbaik dan tinggi. Hal ini tidak terlepas dari peran pendidikan yang selalu membentuk dan mengrahkan meraka dalam keseharian mereka, peran pendidikan baik di sekolah, keluarga dan Lingkungan masyarakat menjadi faktor pendukung didalam pembinaan karakter atau sikap jujur terhadap siswa.
PENINGKATAN PEMBELAJARAN PAI MELALUI DISCOVERY INQUIRY PADA SEKOLAH DASAR DI BANDAR LAMPUNG
Authors: Harianto Jimi , Agung Putri
Published: February 2020

Kenyataan di lapangan banyak dijumpai metode mengajar guru yang belum maksimal khususnya dalam pembelajaran Agama Islam, sehingga dalam proses pembelajaran siswa tidak efektif. Penelitian ini bertujuan untuk mengetahui peningkatan pembelajaran pendidikan agama islam melalui discovery inquiry. Penelitian ini adalah penelitian tindakan kelas (PTK) atau classroom action research, pertama dalam mengembangkan kerja guru yang kolaboratif, sehingga guru diharapkan memahami metode dalam pembelajaran yakni dengan pendekatan discovery inquiry, dan menghasilkan pembelajaran agama islam sesuai dengan kaidah-kaidah pembelajaran yang efektif. Kedua, dalam melaksanakan pendekatan discovery inquiry perlu adanya langkah-langkah dan tujuan pembelajaran yang jelas, sehingga upaya dalam meningkatan pembelajaran agama islam tercapai dengan baik. Selanjutnya penelitian ini menggunakan sistem dua arah yakni menggunakan pendekatan discovery inquiry, yang menjadi subjeknya adalah siswa SD kelas V Way Halim Permai Bandar Lampung. Dalam pelaksanaan tindakan pembelajaran pendidikan agama islam dilakukan perbaikan sebanyak tiga kali pertemuan, kecuali pra siklus. Pada siklus pertama mengalami peningkatan sedang dengan hasil belajar siswa rata-rata 53,34% atau 16 siswa belum memperoleh peningkatan kemampuan. Pada siklus kedua jumlah siswa yang bermasalah sebanyak 16,67% atau berkurang 5 siswa. Dengan ini dapat disimpulkan bahwa peningkatan melalui model Discovery inquiry pada pembelajaran Agama Islam di kelas V SDN 2 way halim permai Bandar Lampung tercapai dengan baik sehingga hasil proses belajar siswa mengalami peningkatan yang signifikan.
PERAN LITERASI MORAL MENINGKATKAN KARAKTER RELIGIUS ANAK USIA DINI
Authors: Sudjarwati Shanti , Fahyuni Eni Fariyatul
Published: February 2020

Penelitian ini bertujuan untuk mengetahui peran penting literasi moral dalam lembaga yang bernuasa Islam memiliki kurikulum lokal  yaitu ke- Aisyiyahan dan Ke- Muhammadiyahan, serta mengembangkan pembiasaan sholat dhuha dengan tertib dan lancar dalam bacaannya, dan rajin bersedekah melatih rasa empati pada usia dini. Penelitian ini merupakan penelitian kualitatif. Subjek dalam penelitian ini ialah peserta didik TK Aisyiyah Bustanul Athfal 5  yang terdiri atas 17. Data dikumpulkan melalui wawancara dan observasi. Data hasil penelitian dianalsis menggunakan teknik analisis data deskriptif.  Berdasarkan penelitian dan perhitungan diperoleh peningkatan dari angka  34 %  menjadi 66%  pada kriteria pengembangaan karakter sudah sholat dengan tertib dan lancar, sedangkan pada jum’at sedekah dari 34 % menjadi 66%  yang mencerminkan perilaku atau akhlak, budi pekerti , karakter religius juga signifikan karena sesuai target jumlah nominal yang diharapkan.
PENGEMBANGAN MEDIA PEMBELAJARAN QUR’AN HADIST DENGAN MAGIC DISC TAJWID
Authors: Zulkarnain Fauzan , Firdaos Rijal , Sada Heru Juabdin
Published: February 2020

Penelitian bertujuan untuk mengembangkan media pembelajaran magic disc tajwid pada mata pelajaran Al-Qur’an Hadist. Metode penelitian ini adalah penelitian dan pengembangan R&D (Research And Development).Penelitian ini mengadopsi teori dari Borg and Gall dengan menggunakan 7 langkah dalam penelitian. Teknik analisis data dalam penelitian ini yaitu dengan teknik deskriptif kuantitatif. Penelitian dan pengembangan ini menghasilkan produk berupa media pembelajaranmagic disc tajwid materi pada pokok bahasan nun mati atau tanwin yang berbentuk piringan yang dapat digunakan. Penilaian tersebut didapatkan dari (1) validator ahli media mendapatkan nilai sebesar 75,1% (2) dari validator ahli materi mendapatkan nilai sebesar 79%. Untuk penilaian tanggapan dari peserta didik pada uji coba lapangan yang dilakukan pada skala kecil mendapatkan penilaian persentase sebesar 83%, dan uji coba lapangan pada skala besar mendapatkan penilaian persentase sebesar 95% yang mana berarti bahwasanya media pembelajaran magic disc tajwid efektif digunakan untuk dapat meningkatkan motivasi, minat belajar peserta didik dan membuat peserta didik lebih aktif dalam belajar.
How Mathematical Reasoning Abilities can be improved? : A Study Case at Islamic Boarding School
Authors: Huda Syamsul , Kharisma Haya Nadirah , Qoma Isti , Jermsittiparsert Kittisak
Published: February 2020

The development of mathematical reasoning ability of students affect the process of settlement of problems exiting in the process og learning matheatics. This study has the objective to determine the learning model that is effective between the Problem Based Learning models and the Learning Cycle 5E models. This study using quantitative study, data analysis techniques using T-test. The study results obtained it can be concluded that, mathematical reasoning ability of students has increased more effectively when the learning proces apply the Problem Based Learning models.
Learning Models to Improved Mathematical Communication Skills
Authors: Purwanto Burhan Eko , Jusmalisa Icha , Sari Indah Permata , Jatmiko Agus , Pasetiyo Andika Eko
Published: February 2020

The problem faced by students in slow learning is in terms of communication. The use of Auditory, Intellectually, Repetition (AIR) and Cooperative Think Pair Share (TPS) types is needed to help students communicate mathematically in expressing mathematical ideas. This study aims to determine whether or not there are differences in mathematical communication skills of students using the Auditory, Intellectually, Repetition (AIR) learning model with students who use Think Pair Share (TPS) Cooperative learning models. This research uses a quantitative approach using the Quasi Experiment method. The research design is in the form of posttest only, non-equivalent group design. Testing data using the T test with Independent Samples T-Test. Based on the results of hypothesis testing obtained p-value> α 0.05. So it was concluded that there were indications of differences between Auditory, Intellectually, Repetition (AIR) learning models with (TPS) Cooperative learning models and superior (AIR) learning models compared to Cooperative learning models of (TPS) Type in influencing students' mathematical communication skills.
Comparison of Somatic, Auditory, Visual, and Intellectual Learning Models and Snowballing Against Numerical Ability of Students
Authors: Irwanto M Zain , Rohman Prabu , Mahfuzh Mahfuzh , Rozikin Ahmad , Sriyakul Thanaporn
Published: February 2020

Numerical ability in learning mathematics is an important thing for students to facilitate teaching and learning process. SAVI and SNAWBALLING are learning models that can facilitate the development of numerical abilities of students. The purpose of this study is to determine the effect of SAVI and SNOWBALLING learning models on the numerical ability of students. This research is a type of research Quasy Experimental Design. The sampling technique used was class random technique with row and series material. The instrument used to collect data was a numerical ability test in the form of a description item. The data analysis technique of this study used the T-Test analysis technique. The results of this study are that the two models do not have the same numerical ability of students, meaning that there are differences in the impact given by the SAVI learning model and the SNOWBALLING learning model on numerical ability. The numerical ability of students using the SAVI learning model is better than using the SNOWBALLING learning model.
Activation of Resources of Older Generation Citizens – Recipients of Social Services (The Expert Survey Results)
Authors:   Institute of Further Professional Training of Social Workers, Vdovina Margarita Vladimirovna
Published: February 2020

The problem of identification and rational usage of resources of the older generation citizens, primarily aimed at their personal development and increase of feasible social activity in connection with the aging of the population is considered in the paper. In modern social work, the task of activation the resources of recipients of social services is also very significant in order to attract their opportunities for self-help and even mutual assistance. The results of original sociological survey of experts working with citizens of the older generation, what opportunities are available to recipients of social services and how these opportunities can be used for the benefit of the older generation and those around them are presented in the paper. Among the most significant resources experts named: personal potential of a person (good character, strong memory, logical thinking, advanced intelligence, sociability, sense of humor, active life position, positive emotional attitude, learning desire, etc.); relatives and their care of the person of the older generation, his ability to be useful to the closest people; psychosomatic capabilities of a person (good health, preserved hearing and vision, mental safety, genetically inherent longevity, the ability to self-service). To activate these and similar resources, experts have proposed such methods as motivation and persuasion, participation of older generation citizens in the activities of the program “Active longevity”, the organization of other activities that allow these people to feel important. Special attention, as many experts believe, should be paid to the involvement of relatives and friends to activate the resources of the recipients of older generation services.