bluuebunny/crossref_metadata_2025 huggingface dataset:
Kekik (Thymus Vulgaris L.) Özütü Kullanarak Biyosentezlenmiş Gümüş Nanopartiküllerin Antibakteriyel Etkisinin Araştırılması
Authors: GÜNEŞ Cansu , AVCI Ahmet
Published: December 2023

Nano boyutlu metaller, bakterilere karşı direnç oluşturma noktasında etkili birer antibakteriyel ajan olarak bilinir. Bu ajanlar özellikle insanlık için ciddi bir tehdit oluşturan ilaca dirençli bakterilerle mücadele etmek için doğal kökenli alternatifler oluşturmaktadır. Gümüş nanopartiküllerin (AgNP'ler) iyi derecede antimikrobiyal aktiviteye sahip olduğu kanıtlanmıştır. AgNP'lerin biyosentezi diğer nanopartikül üretim yöntemlerine kıyasla daha güvenli, düşük maliyetli ve çevre dostu bir yöntem olarak kabul edilmektedir. Bu çalışmada, biyosentez yöntemi kullanılarak Thymus Vulgaris L. sulu özütüyle enkapsüle olmuş gümüş nanopartikül (eAgNP) üretimi başarıyla gerçekleştirilmiştir. AgNP’lere kekik bitkisinin antiseptik, antimikrobiyal ve antioksidatif özelliklerinin kazandırılması amaçlanmıştır. eAgNP üretimini sağlayacak optimum bitki özütü ve AgNO3 konsantrasyonu UV-vis spektrofotometre analizi ile belirlenerek bulunan oranlar doğrultusunda yeşil sentez gerçekleştirilmiştir. Sentezlenen eAgNP'ler UV-Vis spektral analizi, FT-IR, XRD analizi ve TEM görüntü analizi ile karakterize edilmiştir. eAgNP'lerin antimikrobiyal aktivitesi E. coli ve S. aureus bakterileri kullanılarak disk difüzyon metodu ile araştırılmıştır. TEM analizi ile biyosentezlenmiş eAgNP'lerin bitki özütü ile enkapsülasyonunun gerçekleştiği ve 6-70 nm boyut aralığında küresel bir şekle sahip olduğu bulunmuştur. eAgNP'leri çevreleyen bitki kaynaklı fitokimyasalların varlığı FT-IR ile, AgNP oluşumu ise XRD analizi ile kanıtlanmıştır. 5 mg/mL'lik bir konsantrasyonda disklere emdirilen eAgNP'ler, E. coli ve S.aureus bakterilerine karşı sırasıyla 20.5 mm ve 23.2 mm ortalama inhibisyon çapları ile antimikrobiyal aktivite göstermiştir. Sonuçlar, oldukça güçlü antimikrobiyal aktiviteye sahip, çevre dostu eAgNP'lerin Thymus Vulgaris L. özütü kullanılarak hazırlanabileceğini ve biyomalzeme alanında önemli bir potansiyel oluşturabileceğini ortaya koymuştur.
РОЗВИТОК ІНФРАСТРУКТУРИ ТЕРИТОРІАЛЬНИХ ГРОМАД У КРИЗОВИХ УМОВАХ
Authors: Нагорна Ірина
Published: December 2023

У статті наведено теоретичне узагальнення наукових підходів до розвитку інфраструктури на рівні територіальних громад. Автором проведено аналіз сучасного стану розвитку інфраструктури територіальних громад, зокрема досліджено основні тенденції розвитку інфраструктури у кризових умовах. Визначено основні особливості та проблемні аспекти розвитку інфраструктури в умовах воєнного стану. У статті автор зазначає,  сучасні процеси вимагають побудови нових підходів щодо відновлення та подальшого розвитку інфраструктури на загальнодержавному, регіональному та місцевому рівнях. Проблеми вдосконалення процесу управління інфраструктурою стають як ніколи актуальними і вимагають розробки та впровадження нових підходів.
INFORMATION CULTURE AS A KEY ASPECT OF PROFESSIONAL COMPETENCE OF FUTURE TRANSLATORS
Authors: Korinska O.
Published: December 2023

The article deals with the place and importance of information culture in the acquisition of professional competence of future translators. The concept of «professional competence of a translator» is also revealed, and its structure is analyzed, indicating that in order to acquire all components of professional competence, a future specialist in the field of translation needs to master the ability to receive, systematize and use different bits of information, as well as to evaluate and determine its reliability and expediency in the context of professional activity, which requires him/her to have a high level of information culture.

In the process of writing the publication, we also analyzed different views of domestic and foreign researchers regarding the concept of «information culture» and given own definition of the term «translator's information culture». It was proved that information culture can be interpreted as a professional and personal characteristic, which includes the knowledge, skills, and abilities of the future translator to apply information and communication technologies in professional activities, as well as part of his professional culture, which means compliance with all norms and requirements (moral, legal, etc.) when working with information.

The formation of the information culture of a future specialist in the field of translation takes place in three stages: the first is designed to form an idea of the spectrum, content and operational forms of information processes and the basic skills of their implementation; the second is related to the acquisition of skills of effective application of all components of information technologies in translation activities; the third one consists in the formation of a system developed information culture of the individual. All these stages are interconnected and mutually dependent.

In addition, we named the main functions of information culture, among which cognitive, communicative, valuable, educational, creative, worldview and regulatory functions are distinguished.
THE RECEPTION OF AN INTERDISCIPLINARY APPROACH IN SCIENTIFIC THOUGHT
Authors: Ishchenko A.
Published: December 2023

The article examines the degree of study of the interdisciplinary approach in foreign and Ukrainian scientific discourse based on the material of publications of the second half of the 20th – beginning of the 21st century. It is noted that the appearance of a large amount of research works is due to the complexity and multifaceted nature of the phenomenon.

The study traces the formation of the idea of interdisciplinarity, starting from the 70s of the XX century in the works of L. Apostel, H. Berger, M. Boisot, A. Briggs, P. Duguet, H. Heckhausen, E. Jantsch, J. T. Klein, J. Kockelmans, A. Lichnerowicz, G. Michaud, M. Nissani, J. Piaget and others. It was found that the first works focused on understanding the essence of the concept, searching for a comprehensive definition, developing classifications, distinguishing the advantages of an interdisciplinary approach compared to a disciplinary one, studying their connection and interdependence, predicting the future of the concept, etc. Attempts to present the application of the interdisciplinary approach in practice in the works of L. De Greef, G. Post, C. Vink, and L. Wenting were also considered.

In the research process, theoretical (analysis and synthesis, systematization, generalization of scientific literature) and comparative (comparison of different ideas and opinions on the problem) methods were applied. The conclusion states that the understanding of the interdisciplinary approach in the context of scientific research and the higher education system has intensified in the foreign scientific discourse. The scientists focused on the study of the theoretical dimension of the problem and the practical application of the acquired knowledge: the development of programs and projects to solve urgent scientific and educational issues. It is also noted that Ukrainian researchers, relying on the experience of foreign colleagues, are making attempts to develop models of application of the ideas of interdisciplinarity in the education system, and this contributes to the improvement of the domestic educational process.
THE USE OF FLIPPED CLASSROOM TECHNOLOGY IN THE PROCESS OF PROFESSIONAL TRAINING OF FUTURE TEACHERS OF ENGLISH IN PRIMARY SCHOOLS
Authors: Kravets O. , Samborska N.
Published: December 2023

The relevance of the study stems from the change in the educational paradigm from traditional to information and communication using various computer technologies as a result of the global pandemic and martial law in Ukraine. The organisation of the educational process has undergone significant adjustments and updates, in particular, the introduction of blended learning in primary schools. The article explores and clarifies the concepts of "distance learning" and "blended learning" based on the views of various national and foreign scholars. The authors of the article focus on one of the types of blended learning – the method of "flipped learning" or "flipped classroom".

The history of this approach and its improvement by various innovative teachers are analysed. In the course of the study, the definition of the concept of "flipped learning" is clarified and it is found that there are different forms of organising this type of learning. It has been proved that the pedagogical phenomenon of the "flipped classroom" as a form of teaching English in primary school has not received sufficient coverage in the system of professional training of future primary school teachers of English, so this topic is relevant.

The article analyses the content of the concept of professional competence of an English teacher in primary school and finds out that its information component is of particular importance. In accordance with the requirements of professional standards, a graduate of the pedagogical profile should possess and operate the necessary information and communication techniques, including: the ability to apply various means of communication, use non-standard forms and techniques in solving pedagogical tasks in the classroom in online/offline modes. On the example of the training of the Masters of the Institute of Pedagogy of Zhytomyr Ivan Franko State University in the speciality "Primary Education and English Language", examples of the use of the "flipped classroom" as a form of teaching various educational components were given: "Methods of teaching English in primary school", "Innovative technologies of teaching English", "Theory and practice of teaching a foreign language using information and communication technologies".
The formation professional competencies of the future programmers by means of non-formal education
Authors: Postova S. , Feforchuk A. , Nakonechna O. , Kolos K. , Serbyn B.
Published: December 2023

The formation professional competencies of the future programmers by means of non-formal education
The formation of conceptual thinking in the participants in the educational process: a systemic approach
Authors: Voznyuk O. , Gogobets S.
Published: December 2023

The formation of conceptual thinking in the participants in the educational process: a systemic approach
Developing speaking skills by means of authentic video materials in “Practical English language course”
Authors: Borysova N.
Published: December 2023

Developing speaking skills by means of authentic video materials in “Practical English language course”
Pedagogical disciplines as a component of the content of training future music teachers: experience of higher education institutions in Ukraine and China
Authors: Wen Mai , Tverdokhlib T. , Skrypnyk N.
Published: December 2023

Pedagogical disciplines as a component of the content of training future music teachers: experience of higher education institutions in Ukraine and China
ОЦІНКА ФІЛОСОФІЇ РЕНЕ ДЕКАРТА В РАННІХ ПРАЦЯХ ЕТЬЄНА ЖИЛЬСОНА ТА ЖАКА МАРІТЕНА
Authors: Шиманович А.
Published: December 2023

Застосовувана методологія та систематизовані напрацювання розвідок Рене Декарта заслужено вважаються переламною віхою в історії західної філософії та науки. Водночас неотомістський рух першої половини ХХ ст. став парадигмальним прикладом концепції, що ставила собі за мету подолати хаотизацію філософського дискурсу й нестримне множення вчень, обґрунтовуючи легітимність і непозбувну валідність синтезисв. Томи як вічної універсальної філософії, яка заразом є цілком інклюзивною і містить в собі й досі вповні не реалізовану внутрішню потенцію до плідної взаємодії з новітніми світоглядними системами. Попри очевидну значущість Р. Декарта як засадничого теоретика й фактичного засновника проекту Просвітництва, уся сукупність методів його філософської роботи переважно сприймалася провідними неотомістами як своєрідна точка неповернення, що спричинила подальшу деформацію автентичного філософування на імпліцитно християнській основі. Ба більше, в сучасній культурі унормованої фрагментації й вузької тематичної спрямованості філософських розвідок нерідко відчувається жага повернутися до цілісної візії світу, наново віднайти всеохоплююче розуміння людини – її історичного становлення, телеологічного призначення, онтологічної сутності та її інтенційної спрямованості на пізнання Буття. До того ж дається взнаки брак інтегральних концепцій, що базуються на стабільній метафізичній структурі реальності, але які водночас спрямовані на креативне перетворення соціальних реалій, повсякденного людського життя.

В результаті проведеного дослідження є всі підстави зробити наступний висновок: погляди кожного з двох досліджуваних філософів-неотомістів – Е. Жильсона та Ж. Марітена – дозволяють увиразнити основні пункти їхньої фундаментальної незгоди із проектом Р. Декарта. Три основні аргументи кожного з неотомістів щодо згубності Декартової філософії, які лише частково перегукуються між собою, ґрунтуються на одній фундаментальній претензії, яка є наступною: методологічна спрямованість Декарта на розсічення цілісної реальності задля дослідження окремих партикуляризованих царин, позбавлення їх сув’язей та традиційних взаємних реляцій, унормували фрагментоване мислення, спричинивши доглибне подрібнення усталеного впродовж століть бачення реальності й інтерпретації Буття.
Hizkuntzekiko Irakaskuntza Sentsiblearen gaineko usteak: EAEko LHko irakaslegaien iritziak aztergai
Authors: Gaspar Artzai , Galdos Oihane , Saragueta Eider , Van der Worp Karin , Ituiño Leire
Published: December 2023

Euskal Autonomia Erkidegoko (EAE) eskoletan, irakasten diren bi hizkuntza ofizial eta atzerriko hizkuntzaz gain, haur batzuek jatorrizko beste hizkuntza batzuk ere badituzte. Egoera eleanitz horren aurrean Linguistically Sensitive Teaching (LST) aintzat hartzea beharrezkoa da. Ikerketa honetan, EAEko unibertsitateko Lehen Hezkuntzako 14 irakaslegaik LSTaz duten kontzientzia aztertzen da, galdetegia, idatzizko hausnarketa, talde-eztabaida eta behaketen bitartez. Emaitzek erakusten dute irakaslegaiak LSTaren oinarrizko alderdiak identifikatzeko gai direla eta euskararen babesarekin lotzen dutela.
La notación de onomástica no latina en la documentación legerense: aspectos sociolingüísticos
Authors: Lopetegui Semperena Guadalupe
Published: December 2023

El objeto del presente trabajo es analizar determinados usos gráficos aplicados en la onomástica no latina de la documentación latina medieval de Leire. La finalidad de dicho análisis es sistematizar tales usos y precisar los criterios aplicados por los escribas. Nos proponemos también subrayar la importancia del aprendizaje gramatical básico adquirido en las escuelas monásticas y mostrar la influencia de criterios sociolingüísticos y culturales en la preferencia de los escribas por unas variantes gráficas sobre otras.
Hizkuntza-ideologiak. Euskararen biziberritzean eragiteko analisi-tresna
Authors: Artetxe Sarasola Miren
Published: December 2023

Artikulu honetan hizkuntza-ideologia nozioaren baliagarritasuna azpimarratu nahi izan da, euskararen biziberritzearen ikuspegitik. Hizkuntza-ideologien kontzeptuan arakatu da lehenik, bigarrenik, hizkuntza gutxituen eta euskararen kasuan hiztun baten autoritatea baldintzatu dezaketen hainbat marko ideologiko aurkeztu dira, eta hirugarrenik, hizkuntza-ideologia horien baitan euskararen garapenak izan ditzakeen zenbait oztopo aipatu dira, marko ideologiko berrien beharra mahaigaineratuz. Azkenik, ikertzaile gisa hizkuntza-ideologien azterketan sakontzearen beharra azpimarratu da.
Raça/cor da pele e morbimortalidade por COVID-19 no estado de São Paulo - SP
Authors: Santos Jade Alycia Ribeiro e , Uehara Sílvia Carla da Silva André , Corrêa Ana Paula de Vechi
Published: December 2023

Objetivo: analisar a relação entre a raça/cor da pele e a morbimortalidade por COVID-19 no estado de São Paulo-SP. Métodos: Estudo ecológico, retrospectivo e analítico, cujos dados foram coletados no Sistema Estadual de Análise de Dados (SEADE) do Governo do Estado de São Paulo e correspondem ao período de fevereiro de 2020 a setembro de 2021. Na análise de dados, utilizou-se o modelo de regressão com distribuição binomial-negativa múltipla, para comparar a incidência e a mortalidade específica entre as raças/cores de pele. Resultados: ao se compararem as curvas de incidência de COVID-19, houve diferença estatística significativa entre as comparações de todos os grupos de raça/cor da pele. Na comparação entre tendências branca vs parda, o resultado foi p = 0,007; na comparação entre tendências branca vs preta, p = <0,001; na comparação entre tendências parda vs preta, p = 0,003. Porém, quando foram comparadas as tendências de incidência por sexo e faixa etária e as tendências de óbito, não houve diferença estatística. Conclusão: a raça/cor da pele influenciou nas curvas de incidência geral por COVID-19 no estado de São Paulo, porém a não associação com a mortalidade pode estar relacionada com a falta de informação sobre raça/cor/etnia nas fichas de notificação, afetando consequentemente sua disponibilidade nos sistemas de informação, o que reforça a importância da divulgação de dados epidemiológicos oficiais de qualidade.
Introducción de métodos activos en las Enseñanzas Artísticas Superiores de Música en la especialidad de percusión
Authors: Nicolás Ana María Botella , Isusi-Fagoaga Rosa , Raga Lluís Marzal
Published: December 2023

Las Enseñanzas Artísticas Superiores de Música presentan una carencia en cuanto a la implementación de programas de innovación educativa y el uso de metodologías docentes activas, que resultan imprescindibles en la didáctica actual. Este artículo se sistematiza con el objetivo principal de valorar la incorporación de programas de innovación educativa en enseñanzas de características artísticas e indagar sobre la utilización de métodos activos para la mejora de la enseñanza. Para ello, se ha hecho uso de una metodología de investigación cualitativa a partir de una intervención sobre alumnado de estudios superiores de la especialidad de percusión, dividido en grupo experimental y control, tomando como base las piezas para ensemble de los compositores Amadeo Roldán y Edgar Varèse. Los resultados obtenidos, arrojan unos datos que avalan la idoneidad de aplicación de estas innovaciones metodológicas. En las consideraciones finales se plasma que esta intervención ha contribuido a la apertura de nuevas perspectivas para la innovación e investigación dentro de la didáctica musical en las Enseñanzas Artísticas Superiores de Música.
Tambores emoldurados no mundo
Authors: Schettini Marcos Vinicius Lacerda , Peters Ana Paula
Published: December 2023

Existe uma grande variedade de tambores emoldurados na música e na cultura de diferentes tradições do mundo. Com características estruturais análogas, agrupam-se em uma mesma “família” de instrumentos, diferenciando-se pelas variantes morfológicas, pelas formas de execução, pelo timbre e pelos contextos de utilização. Este artigo se ocupa em relacionar e documentar uma série de tambores emoldurados a partir de fontes bibliográficas, mostrando suas histórias, suas características organológicas, formas de execução e aspectos de sua musicalidade. Este trabalho faz parte de uma pesquisa desenvolvida em torno da temática do “pandeiro” e, também, evidencia a relevância da percussão no campo acadêmico em diálogo com áreas de pesquisa histórico e documental em música.
Percussion solo parts in Rogerio Duprat’s Antinomies I
Authors: Stuani Ricardo
Published: December 2023

This article aims to analyse the solo percussion parts in Antinomies I, written for chamber orchestra by Brazilian composer Rogério Duprat (1932–2006) in 1962. Characterised by its graphic notation, the composer uses indeterminacy to lead the orchestra into an unconventional paradigm of sound creation. The analysis focuses on the percussionist's range of choices in order to understand how they affect the macro and microstructural elements of the work. There is considerable scope for choices in the percussion part of Antinomies I, which requires the use of "multi-percussion". Eight of the thirty-two circular structures that form the score are percussion solos. It is a significant number, greater than any other individual instrumentalist from the chamber orchestra. These circles form a heterogeneous group with different degrees of indeterminacy whose analysis reveals the interpretive process of transforming a graphic score into percussion sounds.
Research on the Development and Application of Gender Equality Picture Books and Teaching Aids
Authors: Chaung Ya-Jane , Wu Jia-Hui , Huang Ting-Wen , Tseng Jung-Hsiang
Published: December 2023

We developed gender equality picture books and teaching aids to allow children to learn the concept of gender equality and strengthen the development of fine motor skills. This teaching aid and picture book was patented and won the golden prize in the international invent competition. We analyzed the advantages and disadvantages of commercially available teaching aids related to gender equality and improved the content by establishing the main direction of the design. To validate the usefulness of teaching aids, we created a questionnaire tested for reliability and validity. Then, 32 education and protection personnel were invited to compare traditional gender equality teaching aids and the developed teaching aids. Then, a questionnaire survey was carried out to understand the effectiveness of the developed teaching aids.
A comprehensive study of rare Rhesus phenotype case
Authors: Chumak A. A. , Belyakova V. V. , Maiorova O. A. , Drozd T. S. , Daniletz V. V. , Gantsova E. A. , Eremina I. Z.
Published: December 2023

Introduction. The RH system includes major antigens D, C/c and E/e encoded by two closely related RHD and RHCE genes. Correct identifi cation of Rh antigens in both donors and recipients is the key to proper transfusion practice. However, there are cases when Rh antigens cannot be detected by standard serological typing. For example, –D– phenotype has no expression of C, c, E, and e antigens on the surface of erythrocytes due to various genetic rearrangements in the RHCE gene.Aim: to present a study of a family where two siblings have a defi cient -D-phenotype with a normal rhesus phenotype in the parentsMaterials and methods. A comprehensive study of family N., including parents and two sons was conducted. Initially, an unusual phenotype -D- was identifi ed in the siblings, who are currently donors. All family members identifi ed themselves as Tatars. Serology tests were performed using gel cards. Genomic DNA of family members, as well as cDNA of siblings, was examined by allele-specifi c PCR, exon-scanning assay, and Sanger sequencing. In addition, copy number analysis was performed to identify rearrangements in the RHD and RHCE genes.Results. During serological typing of siblings, only the D antigen was revealed, while the C/c and E/e antigens were absent. Molecular genetic analysis suggested that the cause of the phenotype –D– in the brothers was a hybrid allele RHCE-D(3-8)- CE in homozygous status, forming a haplotype inherited from each parent with the normal RHD allele. The sequence of the fi rst two exons in the hybrid allele corresponded to RHCE*C allele. The parents were heterozygous for the identifi ed allele, so the expression of C/c and E/e antigens was not altered.Conclusion. Two donors with the –D– phenotype were assessed by comprehensive study. Identifi cation of the genetic causes of such variants in recipients is necessary to ensure safety during transfusion of erythrocyte-containing blood components. Genotyping of donors with Rh-defi cient phenotypes is also highly recommended in order to predict the molecular structure of Rh antigens.
Analysis of mutations in EPOR, VHL, EPAS1 and EGLN1 genes associated with the familial erythrocytosis ECYT1-4 among JAK2- and CALR-negative patients with the erythrocytosis of unclear etiology
Authors: Subbotina T. N. , Shalyova A. A. , Khodos G. A. , Oreshkova N. V. , Mikhalev M. A. , Vasiliev E. V. , Dzirkvelishvili G. O. , Dunaeva E. A. , Mironov K. O.
Published: December 2023

Introduction. In addition to the clonal nature of the development of erythrocytosis, there are other causes, such as germinal mutations in genes of proteins responsible for the development of familial inherited erythrocytosis (EPOR, VHL, EPAS1, EGLN1, etc.).Aim. To conduct the analysis of mutations in the EPOR, VHL, EPAS1 and EGLN1 genes associated with the familial erythrocytosis ECYT1-4 among JAK2- and CALR-negative patients.Materials and methods. The study included 50 JAK2- and CALR-negative patients of Krasnoyarsk Krai with erythrocytosis of unclear etiology. Analysis of mutations in the EPOR, VHL, EPAS1 and EGLN1 genes, responsible for the development of familial erythrocytosis was conducted with the use of the Sanger sequencing. A mass parallel sequencing study was also performed for 12 patients.Results. The Sanger sequencing analysis of EPOR, VHL, EPAS1 and EGLN1 revealed any of the genetic variants in 22 of the 50 patients studied. Of all the variants identifi ed in the coding regions of the genes surveyed that result in amino acid substitutions, the following were of biggest interest: 1) two mutations in the VHL gene (rs28940298 and rs5030821) associated with the development of Chuvash polycythemia (ECYT2); 2) rs12097901 variant in the EGLN1 gene associated with altitude adaptation and increasing haemoglobin levels, but with no pathogenetic relevance for erythrocytosis according to ClinVar; and 3) one mutation in the EPOR gene not previously described in literature. According to the results of the NGS study, 12 somatic and 4 putative germinal variants were identifi ed in 5 out of 12 patients.Conclusion. The possibility of conducting a comprehensive molecular genetic study in order to identify new mutations or those already described in the literature in genes associated with familial erythrocytosis could make a signifi cant contribution to the diagnosis of patients with absolute erythrocytosis.
ALCL Protocol of the DOIG Research Institute 2003: results of treatment of anaplastic large cell lymphoma in children in a comparative multicenter clinical trial
Authors: Volkova A. S. , Valiev T. T. , Batmanova N. A. , Yuldasheva S. A. , Gordeeva Z. S. , Sabantsev S. L. , Aleskerova G. A. , Osipova I. V. , Varfolomeeva S. R.
Published: December 2023

Introduction. Anaplastic large cell lymphoma (ALCL) is characterized by clinical, morphological and immunohistochemical heterogeneity. Both intensive block regimens and programs similar to those used in the treatment of acute lymphoblastic leukemia (ALL) are used in therapy. Taking into account the prognostically unfavorable effect of the expression of T-cell markers by tumor cells, a protocol ALCL NII DOIG 2003 was developed, which takes into account not only risk groups, but also immunophenotypic features of the tumor substrate.Aim. To evaluate the treatment effectiveness of children with ALCL according to the protocol ALCL NII DOIG 2003 in comparison with the standard protocol NHL-BFM 95.Materials and methods. The study included 100 patients with newly diagnosed ALCL who received treatment from 2000 to 2023 in 5 federal and regional pediatric oncohematology departments. The patients were divided into 2 groups depending on the protocol of therapy: I group — 48 patients treated with protocol ALCL NII DOIG 2003; II group — 52 patients treated according to the NHL-BFM 95 protocol. The basis of the protocol ALCL NII DOIG 2003 was made up of high-intensity block regimes similar to those used in the treatment of high-risk T-precursor ALL. A comparative assessment of the overall, event-free and relapse-free survival of patients was carried out depending on the therapeutic protocol using the SPSS 21.0 program. Results. The 10-year overall survival rate in patients from I group was 95.3 ± 3.3 %, II group — 82.0 ± 5.4 % (p = 0.037). 10- year event-free survival in I group was 95.3 ± 3.3 %, II — 68.6 ± 6.5 % (p = 0.001). 10-year relapse-free survival in I group of patients was 97.3 ± 2.7 %, while in the II group — 74.4 ± 6.4 % (p = 0.003).Conclusion. The obtained results indicate the high effi ciency of a differentiated, immuno-oriented approach to the treatment of ALCL with the ALCL NII DOIG 2003 protocol, making it possible to achieve signifi cantly higher survival rates of patients compared to the standard treatment protocol.
Semantic displacement in the Diwan of Ibn al-Abbar al-Quda`i al-Andalus
Authors: AlKhatatneh Hamzah
Published: December 2023

خلفية الدراسة ومشكلتها: ينماز الانزياح الدلالي بتلمّس مواطن الإبداع في البناء النصّي، وفق دلالات توثق العلاقة بين العديد من الروابط المتصلة بالسياق كالدال والمدلول، والمعنى ومعنى المعنى، والمعنى وأصله، وقد برز في ديوان ابن الأبّار انزياح استعاري وثق الدلالة بين ما ارتبط بها من موجبات تعود إلى المخاطب كمقتضى الحال، وللمتكلم كالإبداع، وللسياق كالكلام، حتى غدت خرقًا للنظام اللغوي المألوف، في الأثر الذي أضفى على الشعر دلالات خلقت لدى المتلقّي لغةً لم يألفها من قبل الأهداف: هدفت الدراسة لاستنطاق الفنون البيانية التي أسقطها الشاعر ابن الأبّار الأندلسي على جوهر نظمه، وتحليل مواطن فنون التشبيه والاستعارة التي تجلّت إثرها بين المشبه والاستعارة والقرينة الدالّة عليها، ورصد الانزياحات الاستعارية والكشف عن الموجب والأثر، وربطهما بالدلالة والفكرة لمضمون السياق الطرق المستخدمة: اتبع البحث المنهج التحليلي الذي أسهم بتحليل الدلالات الانزياحية التي أسقطها الشاعر على المصطلحات والمعاني المركّبة بين حنايا شعره النتائج: تبلورت فنون البيان في شعرابن الأبّار عن عدة نتائج؛ فشكّلت مدخلاً كبيراً إلى ظاهرة الانزياح التي بدت لازمة معها، وعبّرت عن انزياحات استعارية ودلالية إبان أشعاره ولم تكن مجرّد وصفٍ لمظاهرها، بل عُدّت لثامًا يُغشي ما تبطّن في زخرفها الحقيقي، و استطاعت الدراسة تحليل أشكال العدول والانزياح في الدلالة التي أدّت للخروج عن المألوف في العديد من قصائده التي أضمرت بين ثناياها انزياحًا من المعنى إلى أصله، ومن قصديّة الخطاب إلى عموميته الاستنتاجات (التوصيات و المساهمة): يوصي الباحث بإمعان النظر في دواوين الشعراء الأندلسيين الذين لم تحظ نتاجاتهم بدراسات تحليلية في هذا الجانب
The Reality of English Language Teachers Use of Educational Aids and Techniques in Teaching English in the Second Zarqa Education Directorate from Their Point of View
Authors: Shdefat Nabeel
Published: December 2023

خلفية الدراسة ومشكلتها: تتمثل أهمية تقنيات التعليم في كونها تفسح المجال للطلبة لزيادة خبراتهم، من خلال التنويع في هذه الخبرات، كما تسمح لهم بالتفكير والمشاهدة والفهم، وينبغي تذليل الصعوبات التي تواجه توظيف التقنيات الأهداف: هدفت الدراسة التعرف إلى درجة استخدام معلمي اللغة الإنجليزية للوسائل والتقنيات التعليمية في تدريس اللغة الإنجليزية في مديرية تربية الزرقاء الثانية من وجهة نظرهم، والكشف عن الصعوبات التي تواجههم في استخدام الوسائل والتقنيات التعليمية الطرق المستخدمة: استخدم الباحث المنهج الوصفي المسحي، وتكونت عينة الدراسة من (166) معلمًا ومعلمة، واستخدم الباحث استبانة مكونة من (23) فقرة موزعة إلى مجالين هما: (استخدام معلمي اللغة الإنجليزية للوسائل والتقنيات التعليمية، الصعوبات التي تواجه معلمي اللغة الإنجليزية في استخدام الوسائل والتقنيات التعليمية) كأداة للدراسة النتائج: أظهرت النتائج أنّ درجة استخدام معلمي اللغة الإنجليزية للوسائل والتقنيات التعليمية في تدريس اللغة الإنجليزية في مديرية تربية الزرقاء الثانية جاءت بدرجة متوسطة، والصعوبات التي تواجههم في استخدام الوسائل والتقنيات جاءت بدرجة متوسطة أيضا، في حين لم تكشف النتائج عن وجود أية فروق تُعزى لمتغيرات الدراسة (الجنس، المرحلة الدراسية، سنوات الخبرة) في درجة استخدام التقنيات والوسائل، وفي الصعوبات التي تواجه معلمي اللغة الإنجليزية في استخدام هذه التقنيات الاستنتاجات (التوصيات والمساهمة): أوصى الباحث بضرورة تشجيع معلمي اللغة الإنجليزية على استخدام التقنيات التعليمية الحديثة في التعليم
The Impact of Working Capital Management on the Profitability of Jordanian Companies Listed on the Amman Stock Exchange
Authors: Al Khouri Ritab , Al Fauri Maysa
Published: December 2023

خلفية الدراسة ومشكلتها: تُركّز إدارة رأس المال العامل على المحافظة على توازن مثالي بين الاستثمارات القصيرة الأجل والسيولة، وهي عامل رئيس يؤثر على أداء الشركة وربحيّتها، إنّ زيادة الرّبحية تتطلب الاستثمارات عالية المخاطر، لكن الحفاظ على كميات كبيرة من السيولة يعرّض الشركة لفرص فقدان استثمارات هامة، وبذلك تسعى إدارة رأس المال إلى التوازن بين الأصول والالتزامات القصيرة الأجل لضمان العائد المرجوّ بمستوى مقبول من المخاطرة الأهداف: تهدف هذه الدراسة اختبار أثر صافي رأس المال العامل وكل من مكوناته على ربحية الشركات الأردنية المدرجة في بورصة عمّان، وذلك للفترة ما بين 2009 إلى 2018 الطرق المستخدمة: استخدمت الدراسة عدة مقاييس للربحية منها مقاييس محاسبية وأخرى سوقية، للحصول على نتائج دقيقة، كما استخدمت هذه الدراسة تقنية الانحدار المتعدد النتائج: أظهرت النتائج وجود علاقة إيجابية ذات دلالة إحصائية بين صافي رأس المال العامل ومقاييس الرّبحية المحاسبية للشركات الأردنية، بينما لم تجد الدراسة أية علاقة بين صافي رأس المال العامل ومكوناته ومقياس ربحية الشركات السوقية. وقد بيّنت النتائج أيضًا أن أرباح الشركات تتأثر سلبًا بكل من الزيادة في متوسط فترة التخزين ومتوسط فترة السداد، بينما لم تجد الدراسة أي أثر ذي أهمية لدورة التحويل النقدي على ربحية الشركات الأردنية الاستنتاجات (التوصيات والمساهمة): توصي الدراسة بضرورة الاستثمار الأمثل في رأس المال العامل لتفادي الاستثمارات التي يرافقها تكاليف تخزين عالية، وتخصيص قدر كبير من الموارد في تطوير سياسة فعّالة لإدارة رأس المال العامل تؤدي في النهاية إلى زيادة الربحيّة
Novos arranjos institucionais para a agricultura brasileira: a construção de unidades mistas de pesquisa e inovação
Authors: Radaelli Andressa Benvenutti , Fuck Marcos Paulo
Published: December 2023

O objetivo deste artigo foi analisar o processo de estruturação de novos arranjos institucionais como instrumentos de apoio à pesquisa, ao processo de transferência de tecnologia e à adoção de inovações para a agricultura, com destaque para o modelo de unidades mistas de pesquisa e inovação (UMIPIs), uma iniciativa desenvolvida no âmbito da Empresa Brasileira de Pesquisa Agropecuária (Embrapa). A discussão teve por base a análise dos arranjos institucionais para a agricultura, a evolução da organização da pesquisa agrícola no Brasil, uma avaliação de modelos de gestão de unidades mistas de pesquisa e de inovação e a apresentação das características principais das UMIPIs já implementadas. Observou-se que práticas associativas e movimentos coletivos interagem na organização da pesquisa e no processo de inovação e vêm-se destacando como determinantes nos processos de desenvolvimento de novas organizações e instituições. Essa perspectiva fornece uma forma sistêmica e interativa para apoiar a concepção e implementação de políticas destinadas a fomentar a inovação na agricultura, assim como para analisar o processo de construção e implementação de novos arranjos institucionais que possam contribuir para a elaboração de planos de desenvolvimento voltados às necessidades de determinadas regiões.
Resultados de projetos de inovação transformadora rural: o caso da Rota dos Butiazais
Authors: Mathies Aline , Dias Marcelo Fernandes Pacheco
Published: December 2023

O objetivo deste artigo foi analisar o framework de avaliação de nichos sociotécnicos de inovação transformadora. Na inovação transformadora, o sistema inovador envolve atores de múltiplos níveis da sociedade que buscam desenvolver uma inovação socioambiental. Esses espaços inovadores são denominados de nichos sociotecnológicos. Para responder ao objetivo da pesquisa, realizou-se um estudo de caso do projeto “Rota dos Butiazais”. Os 12 resultados transformadores propostos no framework mostraram-se adequados à avaliação de um projeto rural e possibilitaram uma avaliação formativa e reflexiva sobre o estágio de evolução e a necessidade de novas atividades, a serem desenvolvidas pelo grupo, para fazer o projeto evoluir na direção do alcance dos impactos esperados. Além dos 12 resultados transformadores propostos originalmente, três novos resultados – coordenação, análise das cadeias produtivas emergentes e fomento às alterações socioculturais – foram identificados como necessários ao processo de avaliação formativa. Considera-se que os resultados transformadores podem ser úteis para outros projetos de pesquisa, com foco em sustentabilidade em empresas de pesquisa, assim como podem ser inspiradores às universidades, especialmente no que tange aos projetos integrados de ensino, pesquisa e extensão.
Educación multidisciplinar en trastornos alimentarios: Impulsando el cambio
Authors: García Pérez María
Published: December 2023

Este libro es el resultado de la colaboración multidimensional de profesionales e investigadores en el ámbito de la educación, la psicología, el trabajo social, la enfermería y la medicina que trabajan en el campo de los trastornos de la conducta alimentaria. Se aporta una visión multidisciplinar de la problemática de los trastornos de conducta alimentaria, intentando resaltar las graves consecuencias asociadas a estos y la importancia de una intervención temprana preventiva. En este sentido, esta obra es necesaria para vislumbrar los retos que tienen por delante los profesionales, a nivel interdisciplinar, y las familias acerca del diagnóstico de los factores determinantes y la intervención socioeducativa en relación con los trastornos de conducta alimentaria. La obra se estructura en tres bloques, los cuales se desgranan en diez capítulos, que aluden a los trastornos de conducta alimentaria desde diferentes áreas. En cada uno de los capítulos se valora la utilidad de medidas preventivas y la búsqueda de soluciones ante una problemática que va en auge. La intención es ofrecer al lector una perspectiva relacionada con varias disciplinas científicas, a través de las distintas aportaciones que integran la obra, y que estas resulten de interés para todas aquellas personas preocupadas o dedicadas al ámbito de los trastornos de conducta alimentaria
New approach to assessing the prospects of oil and gas pools on the discovery of oil and gas based on deep concept of formation and use of a wide range of aerospace, morphometric, geological and geophysical data
Authors: Yesypovych Stanislav
Published: December 2023

After investigations of the zone of the hydrocarbon fields by upgraded methods for oil and gas assemblages it is possible to prove position of searching well (wells) on traps of anticline as well nonanticline type. Essential peculiarities of this wells will be high predicted debits of hydrocarbons.
The use of the adaptive spectral indexes for the hydrocarbon deposits exploration using remoteli sensed data and ground-based photometry
Authors: Yakymchuk Vladyslav , Sukhanov Kostiantyn , Porushkevych Anatolii
Published: December 2023

The comparative characteristics of the informative values of the wavelengths of the adaptive spectral index (ASI) of vegetation using remotely sensed data and in-situ measurements, based on the condition of the maximum distance between the average values for the indexes on the points where the gas availability has been confirmed by drilling and on areas without hydrocarbon deposits were obtained. ASI was obtained for the wheat fields over Hlibovskyi gas field (Crimea, Ukraine) and out the deposit using data from Landsat 7, dated 06 June 2010 and the results of in-situ spectrometry dated May 28, 2010.
Monitoring of peat bogs areas to identify fire hazards by remote sensing
Authors: Lischenko Lyidmila , Pazynyzh Nataliia
Published: December 2023

Identified areas of peatbogs in different conditions and determined their fire hazard used the remote sensing data: multi-zone satellite imagery, digital elevation models, aerial and ground servay measurements of land surface temperature.
Considerazioni preliminari sul riuso delle risorse digitali
Authors: Crupi Gianfranco
Published: December 2023

Il contributo intende introdurre il tema del riuso delle risorse digitali facendo riferimento alle più significative esperienze nazionali e internazionali e ad alcune criticità che limitano o impediscono di fatto la sua pratica nell’ambito dei beni culturali: la mancanza di integrazione tra piattaforme, le differenti modalità di accesso e di licenze d’uso, gli interessi economici, la tutela dei brevetti e i diritti di proprietà intellettuale che, nel caso dei vaccini, si è trasformata in un fattore socialmente e politicamente discriminante, gli impedimenti di carattere giuridico, ecc. D’altra parte il valore della Rete (talvolta anche il suo limite) è dato dalla continua rimodulazione dei contenuti, dalla loro continua disaggregazione e riaggregazione in nuove forme, che moltiplicano la conoscenza aprendola a nuovi contesti, producendo nuovi immaginari culturali, «nuovi set didattici» e di apprendimento.
L’Intelligenza Artificiale per il riuso dei patrimoni digitali: stato dell’arte e prospettive future
Authors: Pedrazzi Rebecca
Published: December 2023

Nell’era dei big data, del web 3.0, della cultura digitalizzata in alta definizione, abbiamo a disposizione nuovi strumenti e nuove tecnologie atti a creare inedite modalità di fruizione per il nostro patrimonio digitalizzato. Vengono qui presentati alcuni case studies virtuosi sull’impiego dell’IA per creare connessioni interdisciplinari e per il riuso del patrimonio culturale digitalizzato: da Art Explorer (MET Museum) al progetto Smart Archive Search (Polo del ‘900 di Torino). Una riflessione sulle potenzialità e sulle criticità offerte dai Metaversi e un approfondimento conclusivo sul riuso del patrimonio come dataset impiegato dagli AI Artists per creare opere d’arte.
Linked data: un’opportunità per il riuso
Authors: Possemato Tiziana
Published: December 2023

L’utilizzo delle fonti disponibili sul web costituisce un’enorme opportunità nei processi di conversione dei cataloghi bibliografici in linked open data: i processi di risoluzione delle entità, per identificare gli oggetti nel mondo reale, e i meccanismi di arricchimento dei dati, per potenziare l’esperienza di ricerca da parte dell’utente finale, rende indispensabile l’utilizzo di fonti diverse dai propri dati originari. Ma non tutto ciò che è disponibile sul web è realmente fruibile: fattori legati alla qualità dei dati e all’interoperabilità possono complicare o addirittura impedire lo scambio reciproco di dati informativi. Questa analisi presenta alcuni casi di utilizzo di fonti esterne per i processi sopra citati, evidenziando gli elementi di criticità che più facilmente si incontrano nelle fasi di riutilizzo dei dati e le possibili ipotesi di soluzione.
Istituzioni culturali e riuso del patrimonio culturale digitale: buone pratiche a livello internazionale
Authors: Natale Maria Teresa
Published: December 2023

La condivisione di contenuti digitali non è solo una sfida tecnologica, è un’opportunità e una visione. In questo contributo si presenta una selezione di casi di istituzioni culturali (biblioteche, musei e gallerie d’arte) che hanno reso disponibili le loro collezioni per il riuso, riportando dibattiti interni, sfide, soluzioni proposte. L’impatto generato dall’apertura dei dati può essere molto ampio, stimolando la creatività di start-up digitali e cittadini di tutte le età, il riuso delle collezioni tramite API che consentono di incorporare le raccolte digitali in piattaforme di visualizzazione e apprendimento automatico, l’esposizione su piattaforme esterne come Wikimedia Commons, CC Search, Europeana ecc. L’invito alle istituzioni è che, compatibilmente con quanto permesso dalla normativa nazionale, analizzino i casi di studio presentati, ne identifichino i vantaggi, costruiscano la propria argomentazione e individuino soluzioni per ridurre al minimo i rischi percepiti. Anche se lento, il cambiamento è certamente possibile ed è parte integrante del percorso di transizione digitale cui tutte le istituzioni culturali stanno prendendo parte
Students’ Perception on Game-Based Learning Using Technology: Kahoot! As a Case Study
Authors: Ismail Ismail , Rusdin Rusdin , Prayudi Andi , Taufik Taufik
Published: December 2023

There have been studies which exploring students’ perception on the use of kahoot!. However, research on investigating students’ opinion on the implementation of kahoot and students’ recommendation for educational stake-holders is uncommon. This study relies on semi-structured interview data from 15 second-year students (10 female and 5 male) enrolling in the Introduction to Linguistics Class in English Education Department of STKIP Yapis Dompu. This study aims to explore the benefits of the use of kahoot, the barriers and students’ recommendation to educational stake-holders for improvement. The data were analysed using thematic analysis adapted from (Braun & Clarke, 2006) which consists of 6 steps. The finding of this paper suggested that the implementation of kahoot in learning process had four benefits: Firstly, Kahoot creates fun and interested learning atmosphere. Secondly, it riggers students’ attention and focus. Thirdly, it facilitates comprehension of material Taught. Lastly, Kahoot! fosters positive competitiveness among students. Additionally; there were two main barriers of using kahoot in this research: firstly, limitations on internet access. Secondly, not enough time to answer. The surprising conclusion of the research was that, all participants had never been exposed to game-based learning platform during their formal school (elementary and high school); they only were only exposed to game-based learning platform at this introduction to linguistics class. Therefore; all participants highly recommended to all lecturers and teachers to game-based learning platform in their teaching. This study relied on game-based learning platform kahoot. Therefore, similar study which explores other game-based learning platforms is highly recommended.
Important Factors for User-Generated Content for Tourists Visiting Ciwidey Nature Tourism
Authors: Alimansyah Muhammad Yusuf Iskandar , Octaviany Vany
Published: December 2023

Social media has become the main means in this digital era to share experiences and obtain information on tourist attractions in the form of user generated content which is used as material for tourists to consider when visiting tourist attractions in an area, one of which is the Ciwidey tourist area. This research aims to identify important factors from user generated content on social media for tourists visiting Ciwidey Nature Tourism. This research was carried out with a quantitative descriptive research approach using nonprobability sampling in the form of purposive sampling and factor analysis methods as well as data collection techniques by distributing online questionnaires to tourists who have visited the Ciwidey tourist area. The results of this research show that there are four important user generated content factors including content quality, content attractiveness, level of contribution, and content reputation and popularity with content quality being the most important factor in its contribution to tourists' decisions to visit Ciwidey natural attractions.
Molecular genetic characteristics of Darevskia portschinskii lizard populations based on microsatellite markers analysis
Authors: Martirosyan Irena A. , Odegov Dmitrii O. , Kafarova Ilaha E. , Arakelyan Marine S. , Ryskov Alexey P. , Korchagin Vitaly I.
Published: December 2023

The Caucasian rock lizard species Darevskia portschinskii is one of the bisexual species participating in interspecific hybridisation as the paternal ancestor with the maternal ancestors D. mixta and D. raddei resulting in the successful formation of the parthenogenetic D. dahli and D. rostombekowi, respectively. Populations of D. portschinskii have been previously divided into two subspecies, D. p. portschinskii and D. p. nigrita according to their geographical distribution and the morphological data, but they have not been characterised genetically. Here, we used ten microsatellite markers to determine the genetic structure of the D. portschinskii populations. The utility of the developed microsatellite markers for investigating the genetic variability within and among populations with a heterogeneous spatial distribution was demonstrated. Our results showed that the intra- and interspecific differentiation of the studied populations were consistent with the morphological data on the subspecies status of the D. p. portschinskii and D. p. nigrita populations. A potential applicability of the developed microsatellite markers to study genetic diversity of Darevskia species and subspecies complexes is suggested.