bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of direct analysis in real time (DART) linear ion trap parameters for the detection and quantitation of glucose
Authors: Saang'onyo Daudi S. , Smith Darrin L.
Published: January 2012

Presented here are findings for the development and optimization of a simple, high‐throughput, and rapid method for the analysis of glucose. Because the applications of glucose and other six‐carbon sugars is a growing field of interest especially in the production of biofuels, an efficient and rapid method for their quantitation from lignocelluloses is necessary. Glucose was analyzed using direct analysis in real time (DART) ionization and formed adducts (along with fragmentation) were observed with a linear ion trap (LIT) mass spectrometer. Since DART can be considered a complex thermal desorption ionization process, an optimization study of the helium gas temperature and introduction into the ionization region was performed. It was observed these parameters have a significant effect on the overall signal intensity as well as the signal‐to‐noise ratios in DART mass spectra. Using these optimized parameters, a set of different glucose concentrations (ranging from 10 to 3000 μM) were analyzed and used to determine a linear dynamic range (with the use of an internal standard). The analysis of the samples was done with minimal sample preparation and found to be reproducible on different days. Copyright © 2012 John Wiley & Sons, Ltd.
Application of on‐line nano‐liquid chromatography/mass spectrometry in metabolite identification studies
Authors: Liu Jingzhou , Zhao Zhiyang , Teffera Yohannes
Published: January 2012

Metabolite identification is an important part of the drug discovery and development process. High sensitivity is necessary to identify metabolic products in vitro and in vivo. The most common method utilizes standard high‐performance liquid chromatography (4.6 mm i.d. column and 1 mL/min flow rate) coupled to tandem mass spectrometry (HPLC/MS/MS). We have developed a method that utilizes a nano‐LC system coupled to a high‐resolution tandem mass spectrometer to identify metabolites from in vitro and in vivo samples. Using this approach, we were able to increase the sensitivity of analysis by approximately 1000‐fold over HPLC/MS. In vitro samples were analyzed after simple acetonitrile precipitation, centrifugation, and dilution. The significant improvement in sensitivity enabled us to conduct experiments at very low substrate concentrations (0.01 μM), and very low incubation volumes (20 μL). In vivo samples were injected after simple dilution without any pre‐purification. All the metabolites identified by conventional HPLC/MS/MS were also identified using the nano‐LC method. This study demonstrates a very sensitive approach to identifying phase I and II metabolites with throughput and separation equivalent to the standard HPLC/MS/MS method. Copyright © 2012 John Wiley & Sons, Ltd.
HIGH‐HEAD DAMS AFFECT DOWNSTREAM FISH PASSAGE TIMING AND SURVIVAL IN THE MIDDLE FORK WILLAMETTE RIVER
Authors: Keefer M. L. , Taylor G. A. , Garletts D. F. , Helms C. K. , Gauthier G. A. , Pierce T. M. , Caudill C. C.
Published: January 2012

Many high‐head dams in Oregon's Willamette River basin were constructed without fish passage facilities for downstream migrants. Instead, fish pass dams via hydroelectric turbines, surface spillways or deep‐water regulating outlets. The availability of these routes varies seasonally with dam operations and reservoir depth, which can fluctuate by tens of meters.

To assess how dam and reservoir operations affect fish movement timing and survival, we used rotary screw traps below three Willamette basin dams and at two riverine sites above reservoirs. Traps were operated 2950 days over 8 years, and >195 000 fish were collected. Samples above reservoirs were primarily native salmonids (Oncorhynchus spp.), daces (Rhinichthys spp.) and sculpins (Cottus spp.), while those below dams were often dominated by non‐native Centrarchidae. Capture rates at riverine sites were highest from late winter to early summer, coincident with juvenile Chinook salmon emigration. Conversely, collection below dams was largely restricted to late fall and winter when reservoirs were drawn down to annual lows and discharge was high. We hypothesize that winter operations facilitated fish access to dam turbines and regulating outlets, whereas spring–summer operations entrapped fish in reservoirs and restricted volitional downstream passage.

Total fish mortality was ≤2% at riverine sites and was 36–69% below dams. Estimates were highest for non‐native species and juvenile Chinook salmon. Fatal injuries were consistent with traumas related to pressure, shear and contact and there were size‐related and morphology‐related risk differences. Mitigation opportunities include fish bypass system development, retrofits for existing routes and seasonally appropriate reservoir draw down to allow fish passage. Copyright © 2012 John Wiley & Sons, Ltd.
Value of three‐dimensional hysterosalpingo‐contrast sonography with SonoVue in the assessment of tubal patency
Authors: Zhou L. , Zhang X. , Chen X. , Liao L. , Pan R. , Zhou N. , Di N.
Published: January 2012

Objective

To investigate the accuracy of transvaginal three‐dimensional hysterosalpingo‐contrast sonography using SonoVue (3D SonoVue‐HyCoSy) in the assessment of Fallopian tubal patency.

Methods

We recruited 75 infertile patients undergoing 3D SonoVue‐HyCoSy before standard diagnostic laparoscopy with chromotubation (lap and dye). Tubal patency was assessed by automated 3D coded contrast imaging (3D SonoVue‐HyCoSy), and the findings were compared with the results of lap and dye.

Results

For detecting tubal patency among the 150 Fallopian tubes assessed, 3D SonoVue‐HyCoSy had a sensitivity of 93.5%, specificity of 86.3%, positive and negative predictive values of 87.8% and 92.6%, respectively, and diagnostic accuracy of 90.0%. The test‐positive rates of 3D SonoVue‐HyCoSy vs lap and dye were not significantly different (82/150 vs 77/150, P > 0.05).

Conclusion

3D SonoVue‐HyCoSy should be considered clinically valuable as a practical, non‐invasive, primary investigatory tool for evaluating tubal patency. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
REDD+ governance
Authors: Lederer Markus
Published: January 2012

Reducing emissions from deforestation and degradation (REDD+) has developed into one of the most important carbon governance mechanisms that the international community has at its disposal in the fight against climate change. Deforestation and degradation, particularly in the tropics, constitute one of the major drivers of climate change, the avoidance of which is often portrayed as one of the most effective and efficient options for mitigation. Whether the potential of REDD+ can really be used depends, however, not only on technical issues but even more on how the evolving mechanism is governed on various levels, ranging from the local to the international. The following article analyses some key aspects of REDD+ governance focusing on finance, legal issues, institutional considerations, and potential additional benefits. WIREs Clim Change 2012, 3:107–113. doi: 10.1002/wcc.155

This article is categorized under:

Policy and Governance > Multilevel and Transnational Climate Change Governance
Waste Rapeseed Oil Used as a Binder for Masonry Units: NMR Spectroscopic Analysis
Authors: Heaton T. , Fisher J. , Forth J. P.
Published: January 2012

The chemistry of unsaturated oils used as binders for masonry units is under investigation, as it is likely to be relevant to their long term properties and may be used to improve the manufacturing requirements. The mixing process is followed by heat curing for 24 h, during which time the unit gains strength. The chemistry of this process has been assumed to be a complex series of oxidative and thermal reactions due to the double bonds present in the triacylglycerol (TAG) hydrocarbon chains, producing a heterogeneous, cross‐linked solid matrix which encapsulates solid aggregates. A number of model samples and binder obtained from cured blocks were analysed via several NMR techniques. The reactions are characterised by consumption of polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) and formation of oxygenated compounds, chain‐shortened TAG, free fatty acids (FFA), di‐ and monoacylglycerols (DAG and MAG) and cross‐linked material. The analysis facilitates identification of specific products and mechanisms of formation as the curing progresses, and evidence for instability of particular species in the matrix from samples retrieved after 6 months of storage.
Meteorological Observations and Essays
Authors: Dalton John
Published: January 2012

Famed for his seminal work in the development of atomic theory, John Dalton (1766–1844) was a chemist and natural philosopher who served for years as professor of mathematics and natural philosophy at the New College, Manchester. Dalton was born into a Quaker family in the Lake District; his early interest in weather was inspired by a local instrument-maker and meteorologist. He began keeping a meteorological diary in 1787, and this 1793 book is one of his earliest publications. It contains not only meteorological observations but also speculations about their causes. Beginning with a description of the instruments needed to undertake such investigations, Dalton considers a variety of natural phenomena, finishing by offering various theories on the causes of the Aurora Borealis. This book also contains many of the ideas that would go on to be developed in his future research and publications, for which he is better known.
Journal of a Voyage to Australia, and Round the World for Magnetical Research
Authors: Scoresby William
Published: January 2012

This work by William Scoresby (1789–1857) was edited by Archibald Smith (1813–1872) and published posthumously in 1859. It is the account of Scoresby's final voyage and last scientific study, which took place between February and August 1856. Scoresby made his Australian voyage on board the Royal Charter, owned by the Liverpool and Australia Steam Navigation Company. He wished to observe the changes that take place in the magnetic state of iron ships travelling on a north-to-south magnetic latitude, and to assess how magnetic changes affect the working of a compass so that he could discover the most reliable location for it on board ship. The first part of the work is an exposition of magnetic principles, followed by the results and conclusions of Scoresby's experiments. The second part contains a travel account of the actual voyage. It is a key work of nineteenth-century navigation science.
The Architect of Victory
Authors: Dean Peter J.
Published: January 2012

Lieutenant General Sir Frank Berryman is one of the most important, yet relatively unknown officers in the history of the Australian Army. Despite his reputedly caustic personality and noted conflicts with some senior officers, Berryman was crucial to Australia's success during the Second World War. But did the man known as 'Berry the Bastard' deserve his reputation? Bold, calculating and talented, Berryman was at the forefront of operations that led to the defeat of the Japanese, and his operational planning secured Australia's victories at Bardia, Tobruk and in New Guinea during the Pacific War. With access to rare private papers, Peter Dean charts Berryman's special relationships with senior US and Australian officers such as MacArthur, Chamberlin, Blamey, Lavarack and Morshead, and explains why the man poised to become the next Chief of General Staff would never fulfil his ambition.
Conflict and Effective Demand in Economic Growth
Authors: Skott Peter
Published: January 2012

All capitalist economies experience fluctuations in employment and economic activity around a long-term growth rate. How is this cyclical pattern of growth to be explained? Are the causes of fluctuations in output and employment to be found outside the system or are they intrinsic to the system? Will the long-term growth rate correspond to the growth of the labour force? It is the search for answers to these questions which motivates Peter Skott's analysis. The book develops a theory of dynamic interaction between three types of agent: firms, households and banks. Firms are profit-maximisers operating under conditions of imperfect competition and their production and investment decisions are influenced by monetary and financial factors as well as by the state of the labour market. Households hold financial assets, supply labour and have a direct influence on nominal wage rates. Banks set interest rates on bank loans and deposits. No assumptions are made about nominal price rigidities and the capital-output ratio is determined endogenously. Using a framework of analysis which is rigorous and which does not exclude traditional neoclassical mechanisms, this book demonstrates the validity of important Marxian and Keynesian insights into the growth process.
Conrad's Fiction as Critical Discourse
Authors: Ambrosini Richard
Published: January 2012

Joseph Conrad's comments about his works have commonly been dismissed as theoretically unsophisticated, while the critical notions of James, Woolf and Joyce have come to shape our understanding of the modern novel. Richard Ambrosini's study of Conrad's Fiction as Critical Discourse makes an original claim for the importance of his theoretical ideas as they are formed, tested, and eventually redefined in Heart of Darkness and Lord Jim. Setting the narrator's discourse in these tales in the context of the dynamic interplay of Conrad's fictional with his non-fictional writings, and of the transformations in his narrative forms, Ambrosini defines Conrad's view of fiction and the artistic ideal underlying his commitment as a writer in a new and challenging way. Conrad's innovatory techniques as a novelist are shown in the continuity of his theoretical enterprise, from the early search for an artistic prose and a personal novel form, to the later dislocations of perspective achieved by manipulation of conventions drawn from popular fiction. This reassessment of Conrad's critical thought offers a new perspective on the transition from the Victorian novel to contemporary fiction.
A Mission to Gelele, King of Dahome
Authors: Burton Richard Francis
Published: January 2012

Sir Richard Burton (1821–1890) the famous Victorian explorer, began his career in the Indian army in 1842. While in India he developed his linguistic talent, mastering more than forty different languages and dialects. He turned to writing books in the 1850s and, over the remaining forty years of his life, published dozens of works and more than one hundred articles. He spent part of his career as British consul in Fernando Po (present-day Equatorial Guinea) in West Africa, and used this as an opportunity to explore the region. In 1861, he was sent on a mission, recounted in this two-volume work of 1864, to Dahomey (present-day Benin) to urge the king to put a stop to the local slave trade. In Volume 1 Burton tells of his voyage along the West African coast and arrival in Dahomey, where he is presented to the king.
The Origins of Israeli Mythology
Authors: Ohana David
Published: January 2012

It is claimed that Zionism as a meta-narrative has been formed through contradiction to two alternative models, the Canaanite and crusader narratives. These narratives are the most daring and heretical assaults on Israeli-Jewish identity. The Israelis, according to the Canaanite narrative, are from this place and belong only here; according to the crusader narrative, they are from another place and belong there. The mythological construction of Zionism as a modern crusade describes Israel as a Western colonial enterprise planted in the heart of the East and alien to the area, its logic and its peoples. The nativist construction of Israel as neo-Canaanism demands breaking away from the chain of historical continuity. These are the greatest anxieties that Zionism and Israel needed to encounter and answer forcefully. The Origins of Israeli Mythology seeks to examine the intellectual archaeology of Israeli mythology, as it reveals itself through the Canaanite and crusader narratives.
Proofs and Computations
Authors: Schwichtenberg Helmut , Wainer Stanley S.
Published: January 2012

Driven by the question, 'What is the computational content of a (formal) proof?', this book studies fundamental interactions between proof theory and computability. It provides a unique self-contained text for advanced students and researchers in mathematical logic and computer science. Part I covers basic proof theory, computability and Gödel's theorems. Part II studies and classifies provable recursion in classical systems, from fragments of Peano arithmetic up to Π11–CA0. Ordinal analysis and the (Schwichtenberg–Wainer) subrecursive hierarchies play a central role and are used in proving the 'modified finite Ramsey' and 'extended Kruskal' independence results for PA and Π11–CA0. Part III develops the theoretical underpinnings of the first author's proof assistant MINLOG. Three chapters cover higher-type computability via information systems, a constructive theory TCF of computable functionals, realizability, Dialectica interpretation, computationally significant quantifiers and connectives and polytime complexity in a two-sorted, higher-type arithmetic with linear logic.
Mobilizing Money
Authors: Fohlin Caroline
Published: January 2012

This book examines the origins of modern corporate finance systems during the rapid industrialization period leading up to World War I; leading to three sets of conclusions. First, modern financial systems are rooted in the past, are idiosyncratic to specific countries and are highly path-dependent. Therefore, to understand current financial institutions, we must take stock of the forces at play in the near and distant past. Second, financial institutions and markets do not create economic growth without significant first steps in industrial development and supporting institutions. Third, and most important from the modern policy standpoint, there is no 'one-size-fits-all' solution to financial system design and industrial development. Having specific types of financial institutions is far less important than developing a strong, stable and legally protected financial system with a rich diversity of institutions and vibrant markets that can adapt to changing needs.
Poor Relief in England, 1350–1600
Authors: McIntosh Marjorie Keniston
Published: January 2012

Between the mid-fourteenth century and the Poor Laws of 1598 and 1601, English poor relief moved toward a more coherent and comprehensive network of support. Marjorie McIntosh's study, the first to trace developments across that time span, focuses on three types of assistance: licensed begging and the solicitation of charitable alms; hospitals and almshouses for the bedridden and elderly; and the aid given by parishes. It explores changing conceptions of poverty and charity and altered roles for the church, state and private organizations in the provision of relief. The study highlights the creativity of local people in responding to poverty, cooperation between national levels of government, the problems of fraud and negligence, and mounting concern with proper supervision and accounting. This ground-breaking work challenges existing accounts of the Poor Laws, showing that they addressed problems with forms of aid already in use rather than creating a new system of relief.
Canada, Nova Scotia, New Brunswick, and the Other British Provinces in North America
Authors: Buckingham James Silk
Published: January 2012

The Cornish-born traveller and writer James Silk Buckingham (1786–1855) campaigned energetically for social reform while a Member of Parliament during the 1830s. He later spent four years in North America, and in 1839 travelled on to Canada to investigate its social and economic landscape. In this revealing account, first published in 1843, Buckingham recalls his experiences in the Eastern provinces. He found the Canadians to be civilized, hospitable, hard working and unfailingly loyal to Britain (unlike the independent Americans, who he reports they despised). He also encountered evidence of widespread poverty, and argues that in order to advance Canada's economy and, in turn, that of Britain, new emigrants needed better financial support from the British government. He concludes by calling for a new system whereby land, labour, skill and capital would be optimally utilized, in a pioneering proposal that he expected to prove controversial.
Computational Fluid Dynamics for Engineers
Authors: Andersson Bengt , Andersson Ronnie , Håkansson Love , Mortensen Mikael , Sudiyo Rahman , van Wachem Berend
Published: January 2012

Computational fluid dynamics, CFD, has become an indispensable tool for many engineers. This book gives an introduction to CFD simulations of turbulence, mixing, reaction, combustion and multiphase flows. The emphasis on understanding the physics of these flows helps the engineer to select appropriate models to obtain reliable simulations. Besides presenting the equations involved, the basics and limitations of the models are explained and discussed. The book combined with tutorials, project and power-point lecture notes (all available for download) forms a complete course. The reader is given hands-on experience of drawing, meshing and simulation. The tutorials cover flow and reactions inside a porous catalyst, combustion in turbulent non-premixed flow, and multiphase simulation of evaporation spray respectively. The project deals with design of an industrial-scale selective catalytic reduction process and allows the reader to explore various design improvements and apply best practice guidelines in the CFD simulations.
The Intimate Violence of Political and Economic Change in Southern Ethiopia
Authors: Ellison James
Published: January 2012

In 1960, women in southern Ethiopia's rural Konso district faced a violent campaign by local men to eradicate leather clothing following a ban imposed by the local governor, Tesfaye Hailu. Tesfaye, a man of the northern Amhara ethnic group, banned leather clothes along with bead necklaces and arm bracelets as part of imperial Ethiopia's “modernization,” which was influenced by disparate sources, including the United States. Tesfaye saw women's attire as “backward” and “unhygienic” and as obstructing modernization; its elimination was a means to improve Konso culture and help the empire join the community of modern nations. The “culture” of “the Other” has often been cast as impeding “modernity” and requiring elimination or change, particularly the practices of women, from genital cutting in eastern Africa to veiling among Muslim women in the Middle East and Europe (Hodgson 2009; Masquelier 2005; Merry 2009a). So it was with the widespread, politicized transition to cotton clothing in nineteenth- and twentieth-century eastern Africa. The target was clothing worn by all women in Konso and made by women in the low-status category of “Xauta,” sometimes referred to as a “caste.” Leather skirts signaled important stages in women's lives, and became extensions of individual women's tastes, experiences, and identities. Women today recall the violence and punishments of the campaign, including being chased, beaten, imprisoned, and fined, and even having their skirts forcibly removed at home and in public. They offer contradictory explanations of who initiated the ban and the reasons for it, but they remember clearly the local men involved in eradication efforts.
SECULAR CHANGES IN HEIGHT, BODY WEIGHT, BODY MASS INDEX AND PUBERTAL DEVELOPMENT IN MALE CHILDREN AND ADOLESCENTS IN KRAKOW, POLAND
Authors: KRYST ŁUKASZ , KOWAL MAŁGORZATA , WORONKOWICZ AGNIESZKA , SOBIECKI JAN , CICHOCKA BARBARA ANNA
Published: January 2012

This study examined the secular changes in height, body weight, body mass index and pubertal development in male children and adolescents in Krakow (Poland) over the past 80 years, with an emphasis on the last decade (2000–2010). The survey of the population of Krakow is a continuation of observations conducted in that area for many years. The analysis aims to determine whether in the last decade Krakow still witnessed the secular trend, and what form the trend took. The body height and weight, and body mass index (BMI), of 1862 boys aged 3.5–18.5 years were analysed, against the background of a survey series from the years 1938 (N=1801), 1971 (N=2045), 1983 (N=3124) and 2000 (N=2328). The mean body height, in almost all age categories, was greater than in the past; however the final height over the last decade remained the same. The mean values of body weight and BMI increased, especially in the last decade. Also, an acceleration of puberty in boys was observed. The last 10 years saw an over 3-month decrease in the age of initial appearance of pubic hair in boys. In conclusion, the last decade saw cessation of the growing taller trend: maximum body height stabilized at approximately 179 cm, but weight and BMI increased. Also, a distinct acceleration of puberty was noticed. Lack of height increase, at the same time as weight gain and puberty acceleration, indicate a progressing developmental disharmony.
Do Pension-Related Business Ties Influence Mutual Fund Proxy Voting? Evidence from Shareholder Proposals on Executive Compensation
Authors: Ashraf Rasha , Jayaraman Narayanan , Ryan Harley E.
Published: January 2012

We examine the relation between mutual fund votes on shareholder executive compensation proposals and pension-related business ties between fund families and the firms. In unconditional tests, we find that fund families support management when they have pension ties to the firm. We find no relation when we stratify by fund family in conditional tests, which suggests that fund families with pension ties vote with management at both client and nonclient firms. We confirm this result in an analysis of nonclient firms. Overall, our results suggest that pension-related business ties influence fund families to vote with management at all firms.
Linear internal waves and the control of stratified exchange flows
Authors: McC. HOGG A. , WINTERS K. B. , IVEY G. N.
Published: January 2012

Internal hydraulic theory is often used to describe idealized bi-directional exchange
flow through a constricted channel. This approach is formally applicable to layered
flows in which velocity and density are represented by discontinuous functions that
are constant within discrete layers. The theory relies on the determination of flow
conditions at points of hydraulic control, where long interfacial waves have zero phase
speed. In this paper, we consider hydraulic control in continuously stratified exchange
flows. Such flows occur, for example, in channels connecting stratified reservoirs and
between homogeneous basins when interfacial mixing is significant. Our focus here is
on the propagation characteristics of the gravest vertical-mode internal waves within
a laterally contracting channel.

Two approaches are used to determine the behaviour of waves propagating through
a steady, continuously sheared and stratified exchange flow. In the first, waves are
mechanically excited at discrete locations within a numerically simulated bi-directional
exchange flow and allowed to evolve under linear dynamics. These waves are then
tracked in space and time to determine propagation speeds. A second approach, based
on the stability theory of parallel shear flows and examination of solutions to a sixth-order
eigenvalue problem, is used to interpret the direct excitation experiments. Two
types of gravest mode eigensolutions are identified: vorticity modes, with eigenfunction
maxima centred above and below the region of maximum density gradient, and density
modes with maxima centred on the strongly stratified layer. Density modes have phase
speeds that change sign within the channel and are analogous to the interfacial waves
in hydraulic theory. Vorticity modes have finite propagation speed throughout the
channel but undergo a transition in form: upwind of the transition point the vorticity
mode is trapped in one layer. It is argued that modes trapped in one layer are not
capable of communicating interfacial information, and therefore that the transition
points are analogous to control points. The location of transition points are identified
and used to generalize the notion of hydraulic control in continuously stratified flows.
A DNA vaccine co-expressingTrichinella spiralisMIF and MCD-1 with murine ubiquitin induces partial protective immunity in mice
Authors: Tang F. , Xu L. , Yan R. , Song X. , Li X.
Published: January 2012

Co-expression ofTrichinella spiralismacrophage migration inhibitory factor (TsMIF) withT. spiraliscystatin-like domain protein (TsMCD-1) in a DNA vaccine induces a Th1 immune response and partial protection againstT. spiralisinfection. The present study evaluated whether co-expression of mouse ubiquitin (Ub) withTsMIF andTsMCD-1 might improve the immune response againstT. spiralisinfection. Groups of BALB/c mice were immunized twice at 2-week intervals with 100 μg of plasmid DNA encoding either aTsMIF–TsMCD-1 fusion protein (pVAX1-Tsmif-Tsmcd-1) or an Ub-co-expressing triple fusion protein Ub–TsMIF–TsMCD-1 (pVAX1-Ub-Tsmif-Tsmcd-1). Control animals were immunized with pVAX1-Ubor blank vector plasmid. Specific antibody levels (IgG, IgG1, IgG2a, IgG2b, IgM, IgA, IgE) against the recombinant proteinTsMIF–TsMCD-1, serum cytokines (interferon (IFN)-γ, interleukin (IL)-4, IL-5, transforming growth factor (TGF)-β1 and IL-17), CD4+/CD8+T cells and cytotoxic T lymphocyte (CTL) responses were monitored. Challenge infection was performed 2 weeks after the second immunization and worm burden was assayed at 35 days post-challenge. Antibody responses induced by pVAX1-Ub-Tsmif-Tsmcd-1were significantly lower than forTsMIF-TsMCD-1, but the vaccine induced increased levels of Th1 cytokine (IFN-γ) and increased T-cell cytotoxicity. The reduction of worm burden (37.95%) following immunization with pVAX1-Ub-Tsmif-Tsmcd-1was significantly greater than that induced by the pVAX1-Tsmif-Tsmcd-1vaccine (23.17%;P< 0.05).
The influence of adult worm age and definitive host on the transmission of Echinostoma caproni: egg hatchability and miracidial infectivity
Authors: Muñoz-Antoli C. , Toledo R. , Esteban J.G.
Published: January 2012

We analysed the influence of different ages of Echinostoma caproni adult worms reared in different definitive host-species on egg hatchability and miracidial infectivity. Eggs obtained from 2-, 4- and 6-week-old adult worms collected from rats, hamsters and mice, hatched miracidia that were used to infect laboratory-reared specimens of Biomphalaria glabrata. Highest egg hatchability was obtained with eggs derived from hamsters and mice. Egg hatchability did not seem to be affected by the age of E. caproni adult worms. Miracidial infectivity was not affected by the definitive host species. However, miracidial infectivity was affected by the age of adult worms when they developed in the mice intestine. The long period of miracidial infectivity in hamsters revealed this definitive host as the most suitable for experimental development of the life cycle and parasite transmission.
Fear of the kampung, fear of unrest: urban unemployment and colonial policy in 1930s Java
Authors: INGLESON JOHN
Published: January 2012

This paper discusses the responses of The Netherlands Indies colonial government to the rise in urban unemployment in Java brought about by the 1930s Depression. At least one in six of the large European/Eurasian population in the colony, and an even larger proportion of urban Indonesian workers, became unemployed as a result of the Depression. The colonial government and the European community were greatly concerned that the growth of unemployment among Europeans would lead to destitution for many, ultimately forcing them into the native kampung1. They were also concerned about what they saw as the moral decay of local-born European/Eurasian youth who were unemployed in unprecedented numbers. Furthermore, the European community feared that the growth in unemployment among western-educated Indonesians in the towns and cities in Java would create a fertile recruitment ground for nationalist political parties leading to urban unrest. Fear of the kampung for destitute Europeans, and fear of urban unrest from unemployed western-educated Indonesians, shaped the colonial government's responses to urban unemployment. The impact of the Depression on both Indonesian and European unemployed in the towns and cities in Java triggered lengthy debates on the role of the state in the provision of social security.
NTPDase activity in lymphocytes of rats infected byTrypanosoma evansi
Authors: OLIVEIRA CAMILA B. , DA SILVA ALEKSANDRO S. , SOUZA VIVIANE C. G. , COSTA MARCIO M. , JAQUES JEANDRE A. S. , LEAL DANIELA B. R. , LOPES SONIA T. A. , MONTEIRO SILVIA G.
Published: January 2012

Trypanosoma evansiis the aetiological agent of trypanosomosis in domestic animals. In this pathology, an inflammatory response can be observed and, as a consequence, the increase of extracellular adenine nucleotides such as ATP. These nucleotide concentrations are regulated by ectoenzymes such as NTPDase (EC 3.6.1.5, CD39), which catalyses the hydrolysis of ATP and ADP into AMP. In this study, the activity of NTPDase in lymphocytes of rats experimentally infected withT. evansiwas evaluated. The animals were inoculated with the parasite and monitored by blood smear on a daily basis. The animals were then were divided into 4 groups according to the degree of parasitaemia and period of infection. The blood collections for enzyme analysis and lymphocyte count were performed on the 3rd (beginning of infection), 5th (acute infection) and 15th (chronic infection) days post-infection (p.i.). The control group was composed of non-infected animals. In the infected group a decrease in ATP hydrolysis (36%) was observed on the 3rd day p.i. and a decrease in ADP hydrolysis (62%) was observed on the 5th day p.i. when compared to the control. On the 15th day p.i., an increase in ATP (94%) and ADP (50%) hydrolysis was observed in the infected group. Considering these data it is suggested that NTPDase activity is altered on the surface of lymphocytes of rats infected withT. evansiat different time-points of infection.
Host-parasite associations and host-specificity in haemoparasites of reed bed passerines
Authors: VENTIM RITA , MORAIS JOANA , PARDAL SARA , MENDES LUÍSA , RAMOS JAIME A. , PÉREZ-TRIS JAVIER
Published: January 2012

The host specificity and host sharing of avian haemoparasites (genera Haemoproteus and Plasmodium) is still poorly known, although they infect a large proportion of several studied bird populations. This study used molecular techniques to detect haemoparasites in marsh warblers and in other passerines that feed in reed beds, at 4 sites in Portugal. The host-specificity of the parasite lineages was analysed and compared with other cases described in the literature to assess whether apparent host specificity changes according to the studied system. Nine lineages of Haemoproteus and 15 of Plasmodium were found, of which only 10 Plasmodium were proven to have local transmission. Each lineage was confined to a distinct set of host species. The distribution of parasites in the host species was non-nested, meaning that specialist lineages did not always share hosts with generalists. The most prevalent lineages were those with a wider host range, indicating that the ability to infect more hosts will enhance a parasite's prevalence in its entire host range. We also found that in our areas, a specialist parasite (H. MW1) appears to have a more generalist character than described in the literature, suggesting that a parasite's apparent specialization can depend on the type of host species sampled.
Study ofTrypanosoma cruziepimastigote cell death by NMR-visible mobile lipid analysis
Authors: BENITEZ DIEGO , PEZAROGLO HORACIO , MARTÍNEZ VERÓNICA , CASANOVA GABRIELA , CABRERA GONZALO , GALANTI NORBEL , GONZÁLEZ MERCEDES , CERECETTO HUGO
Published: January 2012

Cell death mechanisms inTrypanosoma cruzihave not been disclosed in detail though different conventional techniques have been used in the classification of parasite-cell death type. Nuclear magnetic resonance (NMR) has successfully been used as a tool to evaluate the onset of apoptosis in a number of higher eukaryote-cell models analysing the ratio of CH2/CH3integration from the visible mobile lipids (VML). Surprisingly, this versatile non-invasive spectroscopy technique has never been employed with this purpose inT. cruzi. In the present study it is shown that under different parasite death-conditions the ratio CH2/CH3varied drastically. Thus,T. cruziepimastigotes in apoptotic conditions increase significantly this ratio while in necrotic as well as in autophagic situations the parasites maintain the VML, CH2/CH3ratio, in normal values. Additionally, other VML markers commonly used in these studies, such as the change in the region of methyl-choline moiety, -N+(CH3)3, exhibited different particular patterns according to the type of cell death. Our results suggest that the1H NMR-VML technique is an adequate tool to discriminate differentT. cruzideath pathways.
Huck Finn, Aristotle, and Anti-Intellectualism in Moral Psychology
Authors: Montmarquet James
Published: January 2012

Jonathan Bennett, Nomy Arpaly, and others see in Huckleberry Finn's apparent praiseworthiness for not turning Jim in (even though this goes against his own moral judgments in the matter) a model for an improved, non-intellectualist approach to moral appraisal. I try to show – both on Aristotelian and on independent grounds – that these positions are fundamentally flawed. In the process, I try to show how Huck may be blameless for lacking what would have been a praiseworthy belief (that I should help Jim), hence, blameless for not acting on this belief; but being ‘blamelessly unpraiseworthy’ is not the same thing as being praiseworthy.
CLINICAL HETEROGENEITY IN SYSTEMATIC REVIEWS AND HEALTH TECHNOLOGY ASSESSMENTS: SYNTHESIS OF GUIDANCE DOCUMENTS AND THE LITERATURE
Authors: Gartlehner Gerald , West Suzanne L. , Mansfield Alyssa J. , Poole Charles , Tant Elizabeth , Lux Linda J. , Lohr Kathleen N.
Published: January 2012

Objectives: The aim of this study was to synthesize best practices for addressing clinical heterogeneity in systematic reviews and health technology assessments (HTAs).

Methods: We abstracted information from guidance documents and methods manuals made available by international organizations that develop systematic reviews and HTAs. We searched PubMed® to identify studies on clinical heterogeneity and subgroup analysis. Two authors independently abstracted and assessed relevant information.

Results: Methods manuals offer various definitions of clinical heterogeneity. In essence, clinical heterogeneity is considered variability in study population characteristics, interventions, and outcomes across studies. It can lead to effect-measure modification or statistical heterogeneity, which is defined as variability in estimated treatment effects beyond what would be expected by random error alone. Clinical and statistical heterogeneity are closely intertwined but they do not have a one-to-one relationship. The presence of statistical heterogeneity does not necessarily indicate that clinical heterogeneity is the causal factor. Methodological heterogeneity, biases, and random error can also cause statistical heterogeneity, alone or in combination with clinical heterogeneity.

Conclusions: Identifying potential modifiers of treatment effects (i.e., effect-measure modifiers) is important for researchers conducting systematic reviews and HTAs. Recognizing clinical heterogeneity and clarifying its implications helps decision makers to identify patients and patient populations who benefit the most, who benefit the least, and who are at greatest risk of experiencing adverse outcomes from a particular intervention.
Four Models of the Fourth Estate: A Typology of Contemporary Chinese Journalists
Authors: Hassid Jonathan
Published: January 2012

Scholarly attention has not kept pace with the rapid changes in the professional role of Chinese journalists. Instead, two older views prevail. The first, which sees Chinese journalists as “mouthpieces” of the Communist Party unchanged from the Maoist era, downplays the tremendous changes in the media since 1978. The second view, holding that they are increasingly becoming “American-style professionals,” overstates the influence of international media norms on Chinese news workers' day-to-day reality. While such communist and American-style professionals do exist in contemporary China, both are far less influential and numerous than stereotypes would suggest. Exclusive scholarly focus on these groups ignores two other more numerous and influential orientations: “advocate professionals,” those who write to influence opinion and policy, and “workaday journalists,” who work mainly for money and lack a commitment to public service. This article delineates all four types of Chinese journalist and explains why an understanding of the latter two professional orientations is critical to understanding China's media, politics and society.
The Media and the Courts: Towards Competitive Supervision?
Authors: Liebman Benjamin L.
Published: January 2012

Scholarship on Chinese governance has examined a range of factors that help to explain the resilience of authoritarianism. One understudied aspect of regime resilience and institutionalization has been the growing importance of supervision by a range of party-state entities. Examining court–media relations in China demonstrates that “competitive supervision” is an increasingly important tool for increasing state responsiveness and improving accountability. Court–media relations suggest that China is seeking to develop novel forms of horizontal accountability. Placing such relations in a broader institutional context also helps to explain why common paradigms used to analyse them may be inapplicable in China.
Chinese Migrant Workers: Rights Attainment Deficits, Rights Consciousness and Personal Strategies
Authors: Wong Linda
Published: January 2012

Dagong打工 as a way of life gives rise to many abuses and rights violations against China's 200 million migrant workers. This article analyses the intricate issues of rights deprivation, rights consciousness and personal strategies of Chinese migrant workers with the research findings from a large sample survey completed at the end of 2005. The data confirm the occurrence of many types of rights abuses, significant levels of rights consciousness, and preference for legal and institutionalized means for rights defence besides the use of private resources. Furthermore, the findings reveal that the experience of discrimination, consciousness of rights and choice of personal strategies are affected by personal backgrounds like age, gender, education and occupational status before migration, which carry implications for policy. Finally, the article comments on the ongoing debate about “rights consciousness” versus “rules consciousness” in contentious Chinese politics.
Mixed Marriages: Conversations in Theology, Ecumenism, Canon Law and Pastoral Practice
Authors: McAreavey John
Published: January 2012

This paper traces the developments in the Catholic law on mixed marriages beginning with an outline of the canonical provisions that were in force prior to the Second Vatican Council. The impact of the Council teaching on ecumenism and religious freedom became apparent with the promulgation of Matrimonii sacramentum (1966), Crescens matrimoniorum (1967) and Matrimonia mixta (1970). These documents put the legislation on mixed marriages on a new footing and provided the basis for the legislation of the 1983 Code of Canon Law. Bishop McAreavey analyses various ecumenical dialogues on mixed marriages: ARCIC, the dialogue between the Lutheran World Federation, the World Alliance of Reformed Churches and the Catholic Church, and ongoing dialogues between the Methodist Church and the Orthodox Church (primarily in the United States) and the Catholic Church. He notes in particular what those discussions have to say on the issue of ‘the promises’ and canonical form and comments on the provisions of the 1983 Code of Canon Law on mixed marriages. He considers the basis of the commitment required of the Catholic party ‘to remove dangers of defecting from the faith’ and the commitment ‘to do all in his or her power in order that all the children be baptised and brought up in the Catholic faith’. He accepts the view of Fr Navarrete that whereas the former obligation is of divine law the latter obligation goes no further than ‘to do his or her best’ (pro viribus in the Latin phrase). In the final section, he reflects on the pastoral impact of developments in the canon law regarding mixed marriages, noting the statements of the World Gatherings of Interchurch Families in Geneva (1998) and in Rome (2003).
The World Health Organization World Mental Health Survey Initiative
Authors: Kessler Ronald C. , Haro Josep Maria , Heeringa Steven G. , Pennell Beth-Ellen , Bedirhan Üstün T.
Published: January 2012

To present an overview of the World Health Organization World Mental Health (WMH) Survey Initiative. The discussion draws on knowledge gleaned from the authors' participation as principals in WMH. WMH has carried out community epidemiological surveys in more than two dozen countries with more than 200,000 completed interviews. Additional surveys are in progress. Clinical reappraisal studies embedded in WMH surveys have been used to develop imputation rules to adjust prevalence estimates for within- and between-country variation in accuracy. WMH interviews include detailed information about sub-threshold manifestations to address the problem of rigid categorical diagnoses not applying equally to all countries. Investigations are now underway of targeted substantive issues. Despite inevitable limitations imposed by existing diagnostic systems and variable expertise in participating countries, WMH has produced an unprecedented amount of high-quality data on the general population cross-national epidemiology of mental disorders. WMH collaborators are in thoughtful and subtle investigations of cross-national variation in validity of diagnostic assessments and a wide range of important substantive topics. Recognizing that WMH is not definitive, finally, insights from this round of surveys are being used to carry out methodological studies aimed at improving the quality of future investigations.