bluuebunny/crossref_metadata_2025 huggingface dataset:
Alternative splicing takes charge of interleukin-22 and interferon lambda 4 signaling
Authors: Lim Chrissie
Published: July 2018

Immune responses require the tight control of dose, location, strength and duration through genetic, epigenetic or biochemical regulation. Of these, the generation of alternatively-spliced constructs increases transcriptional and proteomic diversity in post-transcriptional modification, localization and functional domain integrity. Specifically, this thesis explores how splice variation engenders profound differences in the biological functions of interleukin-22 (IL-22) binding protein (IL-22BP) and interferon lambda 4 (IFNλ4), which are both central components of distinct cytokine pathways in mucosal immunity and inflammation. IL-22BP is a soluble receptor for IL-22 that is expressed as three isoforms in humans, though the physiological relevance of the three human isoforms has remained a mystery due to the absence of this variation in mice. We present novel findings that IL-22BPi1 is inactive due to intracellular retention by its unique exon, while IL-22BPi3 is also an antagonist but with differential activity from IL-22BPi2. Importantly, while IL-22BPi3 has widespread expression in steady-state homeostatic conditions, IL-22BPi2 is the only isoform induced by inflammatory TLR2/retinoic acid stimulation, highlighting important spatiotemporal control of the two isoforms that exploit their differential activities. IFNλ4 presents a different mystery in which the protein-coding variant is genetically associated with poorer clearance, but the mechanism for this association remains unclear. We investigated several non-canonical functions proposed by the field, including intrinsic differences in activity of the three protein isoforms and their interference with antiviral activites of other type I or III interferons. Establishing an overexpression system and purifying recombinant proteins, we found that only the full-length isoform is active and exhibits similar effects to canonical type III IFN IFNλ3, without any blockade of other IFN signaling. Simultaneously, functional IFNλ4 expression is suppressed in hepatocytes and dendritic cells through preferential splicing to increase intron retention and expression of inactive isoforms. Therefore, alternative splicing in IFNλ4 is an important mechanism to control IFNλ4 bioactivity. The divergent manners in which alternative splice forms impact the activity of both IL-22BP and IFNλ4 highlight the important contributions of this process to cytokine biology and bigger implications that escape detection by genomic analyses.
Interest of inhabitants of Sisal, Yucatán on the community development as a tourist centre through the use and management of its cultural and natural heritage
Authors: Lopez-Maldonado Yolanda
Published: July 2018

This thesis analyzes the current dynamics and the phenomenon of the tourism in Sisal, a coastal area where there are natural and cultural attractions with great tourism potential. These sites maintain the beauty of the landscape and provide for the cultural identity of the local people. We could identify the factors included in the evaluation of tourism potential of a Yucatan Peninsula’s coastal community and its proposals that can provide a framework for the creation of tourism activities, promote environmental conservation and improve the quality of life of local people. Sisal was the main commercial port of the Peninsula until the XIX century’s last third and now there are resources with tourism potential on it, that we analyzed from the human ecology perspective, considering the relationship between society-nature. Nowadays the settlement has 1672 inhabitants and their main economic activities are artisanal fisheries and beach tourism. The fieldwork was conducted in May, and from October to December 2010, using a qualitative approach, with techniques such as participant observation and semi-structured interviews. The results allowed identify the use and handling that people makes to its own tourism resources, the interest that people have in the diversification of tourism activities through the site’s tourism potential assessment, emphasizing the combination of natural and cultural attractions of the study area. Also, in a first encounter with the inhabitants of the community we found that they are interested in the protection and management of their own natural and cultural heritage. The opinions of the participants permitted identify the tourism resources of the population such as sinkholes, springs, historical buildings and archaeological sites; analyze their potential attraction, their inclusion in tourism activities as alternatives, and the people’s attitudes towards tourism. An appropriate tourism resources management, with a local people active participation, would play an important role in the conservation of these goods and in the promotion of the place. We remarked the importance of involving local people in the planning of tourism development of the port. The diversity of attractions and its relationship with management, would allow include communities in the processes of tourism activities development.
Setting Boundaries to Solidarity: Explaining Danish and Swedish asylum policy divergences, 1989-2001
Authors: Winkens Kjell
Published: July 2018

This thesis seeks to answer the question 'when, how, and why the Danish asylum system become more restrictive than the Swedish one between 1989 and 2001'. In the analysis of these reasons, a particular emphasis is placed on the different political perceptions of both countries’ welfare philosophies on the one hand, and their political culture on the other. The influence of anti-immigration parties on mainstream political culture is an important part of this analysis. Through a distinction between border and integration policy, it becomes clear that the Danish asylum policy becomes more restrictive in the second half of the 1990s, because of its focus on cultural integration as a duty to the welfare state. The thesis concludes with a discussion regarding the impact of (neoliberal) economic changes on solidarity within political culture.
Intercellular signalling, cell fate and cell shape in the Drosophila pupal wing
Authors: Maartens Aidan
Published: July 2018

The morphogenesis of tissues in animal development is orchestrated by intercellular signalling and executed by cell behaviours such as changes to shape. Understanding the link between signalling and cell shape changes is a key task of developmental biology. This work addresses this problem using the development of the pupal wing of Drosophila melanogaster. The pupal wing is a bilayered epithelium which is patterned into vein and intervein domains, and which secretes the cuticle of the adult wing. I first address the cellular basis of pupal wing development, and show that the process comprises a series of dynamic cell shape changes involving alterations to the apical and basolateral surfaces of the cells. Using temporally controlled mis-expression, I then investigate the role of intercellular signalling in these shape changes, and define the competence of cells in the wing to respond to ectopic signals. The dimensions of signalling in the pupal wing are then investigated, and I show that while BMP ligands can travel between the layers to promote vein development, such signalling is not a prerequisite for cellular differentiation. Within the plane of the epithelium, the BMP ligand Dpp can only induce signalling at a short range, potentially due to the upregulation of receptor levels in receiving cells. Finally, attention is turned to the means by which cell signalling controls cell shape changes, specifically in the crossveins. I identify the RhoGAP Cv-c as a downstream target of BMP signalling which acts to inhibit a novel RhoGTPase function in intervein development. This provides an example of how signalling pathways can enact cell shape changes, via the transcriptional regulation of RhoGAPs.
By Choice or By Chance? Intentional Reverie is Real but Rare
Authors: Westgate Erin Corwin
Published: July 2018

Up to half our lives consists of private internally-focused thought, yet little research has focused on the content and consequences of such thought. The ability to occupy oneself solely by thinking could even reduce stress and increase well-being. However, lab studies suggest that many people do not enjoy intentional thinking and may prefer even negative external stimulation to being alone with their thoughts. Do people deliberately entertain themselves with their thoughts in everyday life and if so, do they enjoy it? Or do people prefer it when such thoughts occur spontaneously? In an experience sampling study, 170 undergraduates responded to texts four times a day for one week, reporting on their thoughts. Overall, people were focused almost equally on the external world around them (48.8% of the time) and on their own inner thoughts (49.3%). On average people chose to entertain themselves with their thoughts approximately 18.48% of the time and reported positive moods while doing so. However, people were in even better moods when desired thoughts occurred spontaneously rather than intentionally. Although people do intentionally engage in enjoyable thinking in everyday life, such thought may make up only a minority of conscious mental activity, and be less enjoyable than spontaneous desired thoughts.
Climbing the social ladder
Authors: Isager Peder Mortvedt
Published: July 2018

Type: Bachelor Thesis - EmpiricalSupervisor: Thomas W. SchubertFinal grade: A (Norwegian grade system)When people think and talk about social status, they often relate it to physical variables such as height, size and numerousity. This have recently lead to the idea that social status might be processed by a generalized magnitude system in the brain that represents magnitude as a feature of several different dimensions, such as size, time and numerousity. In this study I conducted an experiment to test if psychophysical phenomena related to this magnitude system can be found in social status comparisons. Specifically tested here are the size- and distance effect. The results give support to the idea that magnitude is an attribute of social status, albeit with caveats regarding the size effect.
Efficient Control Regulates Bias Under Time Pressure
Authors: Calanchini Jimmy
Published: July 2018

When cognitive capacity is constrained, do responses reflect automatically activated associations, or the ability to efficiently regulate those associations? According to some attitude models, deliberate self-regulatory processes drive response when capacity and motivation are sufficient, but automatically activated associations drive responses when capacity or motivation is constrained. However, other research has demonstrated that some forms of self-regulation operate efficiently enough to influence responses even when cognitive capacity is constrained. Participants completed an explicit measure of racial bias either under normal conditions or conditions that constrain cognitive capacity. Using the Quadruple Process model (Sherman et al., 2008), we estimated the strength of participants' automatic associations and their ability to regulate associations. Results showed that the tendency to demonstrate increased explicit bias under time pressure depended on the extent of efficient self-regulatory processes.
PEMBELAJARAN ANSAMBEL MUSIK DI SMPN 22 SEMARANG
Authors: Unnes eprint-sendratasik , Lestari Puji
Published: July 2018

Seni musik sebagaimana bagian dari mata pelajaran seni budaya diajarkan di SMP baik pada kelas VII, VIII maupun IX. Pelajaran seni musik bisa diberikan dalam bentuk teori maupun praktik. Pada SMP yang menggunakan kurikulum tingkat satuan pendidikan (KTSP) terdapat kompetensi dasar menyajikan karya seni musik tradisional Nusantara secara perseorangan dan berkelompok di kelas atau di sekolah yang harus dicapai oleh siswa salah satunya yaitu di kelas VIII C. Untuk mencapai kompetensi dasar ini, di SMPN 22 Semarang pelaksanaan pembelajaranya cukup unik. Sebab, siswa diajarkan untuk dapat mengekspresikan diri dengan memainkan alat musik gamelan jawa. Seperti yang peneliti ketahui bahwa pada penelitian-penelitian yang telah dilakukan sebelumnya tentang ansambel kebanyakan dilaksanakan dengan menggunakan alat musik modern seperti pianika, recorder maupun gitar. Untuk itu, peneliti tertarik untuk mengetahui bagaimana proses pembelajaran ansambel musik gamelan jawa yang dilaksanakan di kelas VIII C SMPN 22 Semarang dan mengetahui bagaimana tanggapan siswa mengenai faktor-faktor yang mempengaruhi hasil belajar ansambel musik pada siswa kelas VIII C SMPN 22 Semarang.Penelitian ini menggunakan jenis kualitatif deskriptif dengan analisis data menggunakan teknik kuantitatif dan kualitatif (mix methods). Teknik pengumpulan data menggunakan teknik wawancara, studi dokumen, observasi, dan teknik angket. Hasil penelitian menunjukkan bahwa guru seni musik dalam melaksanakan pembelajaran ansambel musik menggunakan tiga tahapyaitu perencanaan, pelaksanaan, dan evaluasi. Pada tahap perencanaan guru mempersiapkan perangkat mengajar berupa silabus dan rencana pelaksanaan pembelajaran (RPP). Tahap pelaksanaan guru melaksanakan tiga kegiatan berupa kegiatan pendahuluan, kegiatan inti dan kegiatan akhir. Pada tahap evaluasi dilaksanakan dalam bentuk tes unjuk kerja. Adapun dalam pembelajaran ansambel musik gamelan jawa, faktor-faktor yang mempengaruhi proses dan hasil belajar ansambel musik gamelan jawa mendapat tanggapan positif dan negatif dari siswa. Tangggapan positif siswa diantaranya yaitu perhatian guru terhadap siswa, hubungan guru dengan siswa, bakat siswa, minat siswa, perhatian siswa, disiplin sekolah, media masa, bentuk kehidupan masyarakat, keadaan ekonomi keluarga, standar kurikulum, alat pelajaran, kesehatan siswa, cara orang tua mendidik, dan pengertian orang tua. Sedangkan faktor-faktor yang mendapat tanggapan negatif dari siswa yaitu perhatian guru dalam memberikan tugas, keadaan gedung, motif siswa, dan standar pelajaran di atas ukuran. Harapanya pembelajaran seni musik lebih direncanakan lagi secara matang agar pelaksanaannya bisa berjalan sesuai dengan perencanaan yang telah dibuat.
Feature extraction from event logs for predictive monitoring of business processes
Authors: Borchert Florian
Published: July 2018

In this master’s thesis, we investigate feature extraction techniques for event log traces. We provide an overview over the field of predictive monitoring and analyze existing trace profiles proposed in the literature. Based on this, we apply the results obtained in recent research on process discovery to find meaningful abstractions over related subsequences of events.We assess different feature sets by evaluating their predictive power in a supervised classification setting as well as a semi-supervised outlier detection setting. For this purpose, we use two datasets from public administration, describing complex processes in EU agricultural subsidy management. Our particular goal in this domain is to predict negative outcomes, for instance, additional work due to legal claims or corrections necessary after initial payment decisions.
Travessias antropologicas do alem-mar: Pos-colonialismos em portugues
Authors: Virgilio Jefferson
Published: July 2018

This thesis presents the research carried out between the years 2014 and 2015 on anthropology in Portugal. It has focus on the period 1980 to 2015 and particularly in establishing relationships with anthropology practiced in Brazil. The methodology includes literature reviews, consulting archives, interviews with anthropologists and participant observation in classrooms and academic meetings. The text proposes approaches and reflections on the relations between Brazilian and Portuguese anthropologies in the last forty years. Produces brief historical review of the institutionalization of the Portuguese anthropology and analyses the privileged relations between the Brazilian and Portuguese anthropologies. There is a presentation of the participating institutions and agents of Lusophone networks being established since the 90s while focused on the relations between Brazil and Portugal as part of postcolonial processes of production of anthropological knowledge.
Law’s Humility: The Possibility of Metajurisprudence
Authors: Gkouvas Triantafyllos
Published: July 2018

This thesis propounds a metatheoretical regimentation of legal claims that can accommodate theoretical disagreement across the board. The solution explored does not question the incommensurability between the descriptive and the normative variants of first-order disputes about the grounds of law. What it targets instead is an unpronounced agnosticism about the possibility of a more inclusive type of metajurisprudential disagreement that does not take for granted either the existence of legal facts—construed either as descriptive or as normative facts about what the law requires—as the trivial truthmakers of propositions of law or their potentially reason-giving properties. On the assumption that the fact that for every legal proposition there is something in the world that makes it true is a premise shared by all legal philosophers but those of an expressivist inclination, an unpronounced, primitive division of opinion occurs as early as one ventures to question that our commitment to the possibility of legal truth logically entails our commitment to entities of a distinctly legal kind. The alternative idea that comes out of the rejection of this entailment will be that part of what could explain the slow pace at which the positivism-antipositivism debate is moving beyond the traditional conceptual jargon of 20th century analytic jurisprudence is the fact that we may have been blind to the possibility that our quest for the ultimate grounds of law could have been taking place under the veil of a narrow understanding of the available options with regard to what could legally exist. In virtue of this reconfiguration the prospect of metajurisprudential disagreement acquires definitive shape. At this higher level of abstraction questions about the perspectival character of legal statements, the constitution of legal authority, the relation of legal truth to reality as well as about the nature of legal grounding and legal normativity become available for meaningful contestation. If there is something that could serve as a leitmotiv for this research proposal is that there is no more apt a byword for what it is to conduct foundational work in legal philosophy than that there is no royal way from semantics to ontology.
Pitting Corrosion on a Water Pipe of the Grade 1.4301
Authors: Strobl S. , Linhardt P. , Ball G. , Haubner R.
Published: July 2018

Pipes made of stainless steel in the drinking water supply system showed pitting corrosion in the heat-affected zone (HAZ) of the welded joints. This was very surprising considering the chemical composition of the fresh water and the fact that no microbiologically influenced corrosion (MIC) had been found.

Testing for pitting corrosion showed no increased sensitivity of the HAZ. The Electrochemical Potentiodynamic Reactivation test (EPR test), however, was positive for the tube interior and only within the HAZ. Metallographic examinations were carried out to clarify if sensitization or intergranular attack, a type of corrosion, were the cause.

The holes showed an irregular propagation which can be explained by segregation lines in the steel. It is noticeable that the holes preferably propagate in the mid-thickness region of the steel sheet. The metallographic samples showed no preferred corrosive attack along the grain boundaries (intergranular attack) and also no sensitization of the steel.
Analysis of Noise Level Generated by Stone Cutter Machine
Authors: Lindawati Lindawati , Fitriadi Nuzuli , Afdhal Afdhal
Published: July 2018

Marble, one of natural stone, has been widely produced since the last decade. In South Aceh, Marble stone is fabricated at Marble Production Unit that is located around Polytechnic of Aceh Selatan. The using of large-scale stone-cutting machines in Marble Production process tends to be a major noise source in Polytechnic of Aceh Selatan environment. The aim of this study is to analyze the noise level generated by Marble Cutting Machine in Marble Production Unit. The noise levels were analyzed by measuring Background Noise Level (BNL) and Sound Pressure Level (SPL). Sound Level Meter Type SL-814 was employed in the measurement. The results show that Background Noise Level measured is 53.03 dB on average. The highest Sound Pressure Level measured when the marble cutting machine was operated without workpiece is 94dB. In addition, the highest sound pressure level measured when marble cutting machine was operated with the workpiece is 96 dB. The values have generally exceeded the Threshold Noise Level allowed for education area, 55 dB. The noisy condition in campus environment would have an impact on teaching and learning processes within the Polytechnic of South Aceh.
Desain dan Implementasi Sistem Monitoring Ruangan di STMIK STIKOM Indonesia
Authors: Kusuma Aniek Suryanti , Minartiningtyas Brigida Arie , Sri Artha I Made Gede
Published: July 2018

STMIK STIKOM Indonesia sebagai salah satu institusi di bidang pendidikan yang berbasis komputer telah menjalankan sistem monitoring penggunaan ruang kuliah namun masih dikerjakan secara manual. Kendala yang dihadapi karena kondisi tersebut adalah petugas Office Boy tidak mengetahui jam mulai dan berakhirnya perkuliahan, hal ini mengakibatkan tidak efisiennya sumber daya listrik yang digunakan serta dapat mengurangi umur ekonomis fasilitas yang terdapat di ruang perkuliahan. Kendala lainnya dari BAA adalah pelaporan kehadiran dosen membutuhkan waktu yang cukup lama sehingga pihak manajemen tidak dapat memantau kedisiplinan dosen setiap saat. Sistem Monitoring Penggunaan Ruangan dibangun dengan tujuan agar petugas Office Boy dapat memantau penggunaan ruang perkuliahan sehingga diharapkan dapat meningkatkan efisiensi sumber daya listrik pada masing-masing ruangan serta mampu memperpanjang umur ekonomis fasilitas yang terdapat pada ruangan tersebut. Sistem ini juga mampu menghasilkan laporan kehadiran dosen, sehingga pihak manajemen dapat memantau kedisplinan setiap dosen pengampu matakuliah. Perancangan sistem ini dijabarkan melalui Data Flow Diagram (DFD) dan dibangun dengan menggunakan metodologi Waterfall.
Sistem Informasi Monitoring kebersihan STMIK STIKOM Indonesia Berbasis Mobile
Authors: Sudiarsa I Wayan , Supartha I Kadek Dwi Gandika
Published: July 2018

Sebuah fasilitas setelah terwujud memerlukan perawatan yang baik, terstruktur dan berkesinambungan. Perawatan fasilitas STMIK STIKOM Indonesia berada di bawah koordinasi kepala rumahtangga yang dilaksanakan oleh bagian teknisi dan bagian umum. Untuk menjaga kebersihan failitas di kampus STMIK STIKOM Indonesia maka di buatlah prosedur monitoring kebersihan yang dilakukan setiap hari. Dalam pengawasan kebersihan Kepala rumah tangga melakukan monitoring hari terhadap proses pelaksanaan kebersihan yang dilakukan oleh bagian umum. Dalam pelaksanaanya kepala rumah tangga mengalami kesulitan dalam pencatatan, karena padatnya agenda pekerjaan yang dilaksanakan, sehingga perekapan hasil kebersihan dalam catatan fisik seringkali tertunda untuk di rekap ke dalam sistem komputer. Hal ini menjadi krusial karena keterlambatan perekapan akan menunda pelaporan ke atasan dan berpengaruh terhadap penundaan perangkingan dari bagian umum yang yang harus di laporkan setiap bulannya. Dari hasil pengujian Sistem Informasi monitoring berbasis mobile mampu untuk menyelesaikan permasalahan yang ada pada proses rekapitulasi kebersihan kampus STMIK STIKOM Indonesia.
Pengenalan Aplikasi Komputer e-SPT Perpajakan dalam rangka meningkatkan kualitas mutu pendidikan di STMIK STIKOM Indonesia
Authors: Sunarya I Wayan
Published: July 2018

Taxation is one of the parts contained in the company, especially in the reporting of tax made by the company to the Direktorat Jenderal Pajak. Currently for easy tax reporting, the Direktorat Jenderal Pajak provides several software/applications (tax software) to taxpayers, which aims to simplify tax reporting. The computer or software applications commonly used within the company are e-SPT. Students STMIK STIKOM Indonesia must know about this tax application; so in the future is expected to be able to apply this software where students will work after completing his education in STMIK STIKOM Indonesia.
Pengembangan Game Bahaya NAPZA Berbasis Mobile Sebagai Media Sosialisasi PIK-M STIKI INDONESIA
Authors: Ardiana Dewa Putu Yudhi
Published: July 2018

Pemuda memegang peranan penting dalam pembangunan dan kemajuan bangsa. Seiring dengan globalisasi banyak permasalahan yang dialami oleh pemuda. Upaya dari pemerintah adalah membentuk Pusat Informasi dan Konseling (PIK). PIK-M STIKI Indonesia adalah organisasi mahasiswa yang terdapat pada STMIK STIKOM Indonesia yang bertujuan mensosialisasikan program Generasi Berenana (GenRe) pada mahasiswa khususnya dan masyarakat pada umumnya. Permasalahan yang dialami oleh PIK-M STIKI Indonesia adalah belum adanya media yang dapat dipergunakan untuk sosialisasi. Penelitian ini bertujuan mengembangkan media sosialisasi berupa Game berbasis mobile yang dapat membantu PIK-M STIKI Indonesia mensosialisasikan program GenRe.
Boneka Edukasi Menggunakan Voice Recognition Berbasis ATmega328 Sebagai Media Pembelajaran Anatomi Tubuh Manusia Pada Anak Balita
Authors: Ngurah Desnanjaya I Gusti Made , Pramana Putra Bagus Made Deddy
Published: July 2018

Dalam melatih kecerdasan kognitif anak usia dini, diperlukan media pembelajaran yang dapat membantu anak untuk melatih kecerdasan kognitifnya dengan cepat. Penelitian ini bertujuan untuk merancang sebuah media pembelajaran berupa boneka yang dapat digunakan untuk memperkenalkan anatomi tubuh manusia pada anak batita. Boneka edukasi ini memanfaatkan teknologi voice recognition dari modul EasyVR untuk menerima perintah dari pengguna. Untuk mengenalkan bagian tubuh pada boneka, digunakan LED sebagai indikator. Selain memberikan pengenalan anatomi tubuh manusia, boneka ini juga dapat memberikan sapaan kepada pengguna dengan memainkan suara yang tersimpan sebelumnya pada modul sound recorder. Hasil yang diperoleh dari penelitian ini adalah, boneka edukasi ini dapat mendeteksi lebih dari 1 suara dan perintah-perintah yang diucapkan dapat dideteksi secara acak. Untuk jarak efektif boneka edukasi ini dalam mendeteksi suara adalah hingga jarak 2,5 meter.
Wajah Intelektual Bangsa Dalam MEA: Sinergi Pustakawan dan Pemustaka Dalam Globalisasi Pendidikan
Authors: Widiastutik Sri
Published: July 2018

Potensi sumber daya manusia yang berkualitas adalah modal penting dalam wajah intelektual bangsa dalam Masyarakat Ekonomi Asean. Peran perpustakaan sebagai lembaga penunjang proses pendidikan yang berkualitas, harus terus dibenahi dan ditingkatkan. Siapkah Indonesia mengikuti arus tuntutan globalisasi? Mengingat dampak globalisasi pendidikan terhadap perpustakaan bermuara pada kualitas layanan berstandar internasional dengan biaya besar, mulai pembangunan infrastruktur, akses internet, koleksi berbahasa Inggris, berlangganan jurnal internasional, stakeholders’ support. Lebih memperihatinkan rendahnya budaya minat baca pengguna perpustakaan tidak sebanding dengan koleksi pustaka tersedia, apalagi jika buku berbahasa Inggris. Kesulitan mengakses internet dan mengoperasikan komputer sehingga lebih memilih cara manual. Ini dapat diasumsikan bahwa pengguna perpustakaan masih dalam taraf tertinggal, dengan kata lain belum siap dengan layanan berstandar internasional. Penelitian ini bertujuan mengajak pustakawan dan pemustaka bersama-sama berkompetisi secara sehat, melatih diri, sadar dengan kemajuan teknologi dan informasi, serta legowo belajar hal baru, sebagai langkah menaikkan peringkat bahwa Bangsa kita “siap” dengan globalisasi pendidikan.
Rancang Bangun Alat Praktikum Mikrokontroler Di Stmik Stikom Indonesia
Authors: Desnanjaya I Gusti Made Ngurah , Gandhika Supartha I Kadek Dwi
Published: July 2018

Ilmu pengetahuan dan teknologi dalam dunia sistem kendali dan otomatis semakin pesat, yang dapat dilihat pada kehidupan sehari-hari. Kebutuhan manusia yang semakin kompleks memungkinkan untuk dibuat IC yang bisa di program sesuai dengan kebutuhan. Berdasarkan kemajuan teknologi ini, maka berkembanglah suatu ilmu yang merupakan pengembangan dari dunia elektronika, salah satunya yakni dalam bidang mikrokontroler. STMIK STIKOM Indonesia sebagai kampus yang bergerak di bidang tenologi berkeyakinan membangun generasi muda yang dapat terjun langsung kemasyarakat untuk membuat atau mendisain sendiri teknologi yang dapat di kontrol atau bergerak secara outomatis. Dengan sebuah alat modul mikrokontroler diharapkan mahasiswa dapat lebih mengeri dan memahami bagaimana sistem kerja dari mikrokontroler. Mahasiswa dapat merancang dan membuat sistem kendali outomatis yang dapat membantu tugas manusia dalam melakukan aktivitasnya, ataupun melakukan suatu hal yang mungkin tidak bisa dilakukan oleh manusia. Maka dilakukan penelitian Rancang Bangun Alat Praktikum Mikrokontroler di STMIK STIKOM Indonesia.
Editors' Introduction: Reflections on the First Issue
Authors: Ferrari Martina , Fitzpatrick Devin , McLay Sarah , Hayes Shannon , Rathe Kaja Jenssen , Zimmer Amie
Published: July 2018

We are happy to feature four invited submissions by Lisa Guenther, Kym Maclaren, Bonnie Mann, and Gayle Salamon, all of whom respond to the questions motivating our inaugural issue. Both Salamon and Maclaren offer a response to the question “What is critical phenomenology?” by exploring the productive relationship between critical theory and phenomenology. Salamon does this by tracing the history of the term critical phenomenology. Maclaren further explores the productive relationship between critical theory and phenomenology en route to her analysis of intimacy. Focusing on the phenomena of shame and long-term solitary confinement, Mann and Guenther take up that question by performing the work of critical phenomenology. Mann also offers suggestions regarding critical or, as she calls it, feminist phenomenology’s relation to the tradition—both of classical phenomenology and feminist philosophy. Guenther shows how the work of critical phenomenology is already at play in the practices of resistance among prisoners in the Security Housing Unit of Pelican Bay State Prison in California.
Comunicação da aura e da autenticidade nas reproduções digitais: relembrando Walter Benjamin*
Authors: Junior Norman Melchor R. Peña
Published: July 2018

A comunicação da aura e da autenticidade é um processo concomitante aos efeitos totalizantes da ligeira transição dos processos de reprodução mecânica para as formas de reprodução tecnológica e digital. Este artigo apresenta e examina que tais movimentos não são apenas o resultado de uma evolução narrativa, mas também uma emergente revolução. Tais afirmações se apoiam no livro A obra de arte na era da reprodutibilidade técnica, de Walter Benjamin, que descreve: (1) um modo de redescobrir e readquirir a aura e a autenticidade deterioradas nos processos de reproduções mecânicas e digitais, as quais provocam colapso em comunicação; (2) manifestações e formas de aura e autenticidade, encarnadas na reprodução da mídia digital, sobretudo nas mídias sociais; (3) formas do ler e da leitura da autenticidade na comunicação atual.Palavras-chaves: Aura. Autenticidade. Walter Benjamin. Reprodução digital. Conteúdo gerado pelo usuário. Interpretação.
América Latina: solitária na indústria jornalística, presente na imprensa das classes populares
Authors: Barbosa Alexandre
Published: July 2018

Este artigo mostra como a América Latina pode se tornar categoria de seleção e construção de notícias para a imprensa das classes populares, como por exemplo, para o Jornal dos Sem Terra, publicação mensal do Movimento dos Trabalhadores Rurais Sem Terra (MST). Para usar a figura de Gabriel García Márquez em Cem anos de solidão, a América Latina é solitária quando se refere aos critérios de noticiabilidade na imprensa hegemônica brasileira, mas se converte em instrumento de identidade e solidariedade para a imprensa dos movimentos sociais, como defendia Mario Kaplún.Palavras-chave: América Latina. Imprensa das classes populares. Critérios de noticiabilidade. Jornal do MST.
Teacher views on the curriculum of elementary school third grade science course
Authors: Başar Tarık , Yağcı Esed
Published: July 2018

This study has been carried out with the aim of evaluating the Curriculum of Elementary School Third Grade Science Course, which has been implemented for the first time in the academic year of 2014-2015, based on the views of teachers. The general screening model has been employed in the study. This research has been conducted with the participation of 36 classroom teachers, who have been determined via maximum variety sampling method from schools that are classified as high level, medium level, and low level in terms of their success. These semi-structured interviews have been audio-recorded with the permission of the teachers. Content analysis has been used in order to analyze the data, The results of the study suggest that the teachers in all three school levels have positive views on the curriculum. According to the teachers, the fact that the curriculum does not offer any activity examples on the teaching-learning process and students' workbook are what the curriculum lacks.
Technique: open lumbar decompression and fusion with the Excelsius GPS robot
Authors: Zygourakis Corinna C. , Ahmed A. Karim , Kalb Samuel , Zhu Alex M. , Bydon Ali , Crawford Neil R. , Theodore Nicholas
Published: July 2018

The Excelsius GPS (Globus Medical, Inc.) was approved by the FDA in 2017. This novel robot allows for real-time intraoperative imaging, registration, and direct screw insertion through a rigid external arm—without the need for interspinous clamps or K-wires. The authors present one of the first operative cases utilizing the Excelsius GPS robotic system in spinal surgery. A 75-year-old man presented with severe lower back pain and left leg radiculopathy. He had previously undergone 3 decompressive surgeries from L3 to L5, with evidence of instability and loss of sagittal balance. Robotic assistance was utilized to perform a revision decompression with instrumented fusion from L3 to S1. The usage of robotic assistance in spinal surgery may be an invaluable resource in minimally invasive cases, minimizing the need for fluoroscopy, or in those with abnormal anatomical landmarks.

The video can be found here: https://youtu.be/yVI-sJWf9Iw.
12 Years a Slave as a Bridge to Primary Source Research
Authors: Mantler Gordon
Published: July 2018

This historical analysis essay on the film 12 Years a Slave and several primary sources bridges earlier skills-based writing prompts with the final research project. It asks students to practice several essential writing moves that reflect the disciplinary approach of historians, without forgetting the concerns of film studies and literature scholars, and even filmmakers. Such moves include conducting careful primary source analysis and interrogation as a historian would; beginning to find sources on one's own (rather than being provided already curated materials); and formally analyzing a film in-depth, including commenting on filmmakers' techniques and how such choices impact the content that viewers witness.
Integrating Course Material and Application: A Progressive Writing Assignment Applied to an Astrochemistry Tutorial
Authors: Wilkins Olivia H , Buzard Camillus F
Published: July 2018

A major challenge in teaching is helping students integrate course concepts to understand the big picture of a field and apply those concepts in new situations. To address this challenge in a tutorial course about astrochemistry (taught by graduate students to chemistry undergraduates), we implemented a progressive writing assignment that culminated in a final presentation. In the progressive writing assignment, students chose an astrochemistry topic they found interesting to be the subject of three sequential papers, which became the basis for their presentations. The purpose of this assignment was to gradually introduce chemistry students to research areas in astronomy, which is by nature outside the general chemistry curriculum, while also providing students with regular feedback. Over the course of the assignment, students applied key themes in the course—significance of astrochemistry research, research methods, and chemistry in astronomical environments—separately to their chosen topics before explaining in the final presentation how these different aspects of astrochemistry work together. By incorporating stories and anaologies, rather than just facts, students gave presentations that were accessible to a novice audience. As a result, students explained broader impacts of astrochemistry research, rather than just focusing on results, and they entertained questions with answers that went beyond clarification of the material discussed.
Writing the Selfie: Using Selfies to Practice Character Presentation and Rhetorical Discourse
Authors: Sessolo Simone
Published: July 2018

“The Selfie Project” is the final assignment in an upper-level undergraduate course on writing with digital and social media. The assignment intends to increase students' awareness of their everyday practices by asking them to critically analyze the act of taking pictures of themselves. Selfies have become an integral part of students' daily lives. For example, students post selfies on social media, they take selfies at parties and on vacation, and they use them to connect with their communities. Though they might seem inconsequential, selfies are rhetorically rich sites of character presentation in the world of social media: practicing their composition offers students a novel way to enhance understanding of character presentation in social media. With this assignment, students successfully brainstorm, compose, and revise rhetorical content in a genre they are already culturally familiar with.
Cultivating a Global Perspective through Refugee Narratives
Authors: MacDonald Michael T.
Published: July 2018

The intention of this assignment is to use stories of refugee experience to cultivate a global perspective in the classroom. The final project of an intermediate college writing course (sophomore and junior level), this assignment asked students to research a topic related to refugee resettlement, apply ideas from course readings to that topic, and reflect on their own perspectives as readers and writers. This writing took the form of a textual analysis essay that combined primary and secondary sources grounded in library research. An emphasis on close-reading and rhetorical analysis provided students with strategies for moving between different modes of literacy (i.e. storytelling, theory, and reflection). The assignment was scaffolded throughout the semester by diverse readings that included memoir, journalist accounts, and scholarship in refugee studies. Although cultivating a global perspective with students was a central learning outcome of this assignment, the term proved difficult to define. This essay discusses how working with student writing provided some clarity on what a global perspective can mean.
EASA’s “Open” Category for Military UAS: Opportunities and Limitations in the Field of Airworthiness
Authors: Hirling Oliver , Holzapfel Florian
Published: July 2018

The European Aviation Safety Agency (EASA) plans to establish a sole risk-based set of regulations for drones to grant access to European airspace, thus opening a multibillion-euro market. One part of this new regulation set is the so-called “open” category, imposing only a minimum set of regulations. The EASA’s approach presents a strong converse to traditional and prescriptive airworthiness regulations. For decades, unmanned aircraft systems (UAS) have been state-of-the-art assets in military forces. Aiming at the fulfilment of complex missions in extreme environments, in different theatres of operation, and with different partners, military UAS need to be reliable, safe, and interoperable. Therefore, NATO established internationally accepted airworthiness standards. However, these standards might be too severe to be adhered to by small, commercial, off-the-shelf UAS in the up-to-25 kg category, preventing the military from benefiting from the now fast-growing civil drone market. Based on a sound literature review, the paper presents the EASA’s upcoming regulations for civil UAS and discusses if they are applicable to military UAS. Possible opportunities, challenges, and limitations of applying the approach for the military are shown.
Transient Temperature Effects on the Aerothermoelastic Response of a Simple Wing
Authors: Vio Gareth A. , Munk David J. , Verstraete Dries
Published: July 2018

Aerothermoelasticity plays a vital role in the design and optimisation of hypersonic aircraft. Furthermore, the transient and nonlinear effects of the harsh thermal and aerodynamic environment a lifting surface is in cannot be ignored. This article investigates the effects of transient temperatures on the flutter behavior of a three-dimensional wing with a control surface and compares results for transient and steady-state temperature distributions. The time-varying temperature distribution is applied through the unsteady heat conduction equation coupled to nonlinear aerodynamics calculated using 3rd order piston theory. The effect of a transient temperature distribution on the flutter velocity is investigated and the results are compared with a steady-state heat distribution. The steady-state condition proves to over-compensate the effects of heat on the flutter response, whereas the transient case displays the effects of a constantly changing heat load by varying the response as time progresses.
OptMAVEn-2.0: De novo Design of Variable Antibody Regions against Targeted Antigen Epitopes
Authors: Chowdhury Ratul , Allan Matthew F. , Maranas Costas D.
Published: July 2018

Monoclonal antibodies are becoming increasingly important therapeutic agents for the treatment of cancers, infectious diseases, and autoimmune disorders. However, laboratory-based methods of developing therapeutic monoclonal antibodies (e.g., immunized mice, hybridomas, and phage display) are time-consuming and are often unable to target a specific antigen epitope or reach (sub)nanomolar levels of affinity. To this end, we developed Optimal Method for Antibody Variable region Engineering (OptMAVEn) for de novo design of humanized monoclonal antibody variable regions targeting a specific antigen epitope. In this work, we introduce OptMAVEn-2.0, which improves upon OptMAVEn by (1) reducing computational resource requirements without compromising design quality; (2) clustering the designs to better identify high-affinity antibodies; and (3) eliminating intra-antibody steric clashes using an updated set of clashing parts from the Modular Antibody Parts (MAPs) database. Benchmarking on a set of 10 antigens revealed that OptMAVEn-2.0 uses an average of 74% less CPU time and 84% less disk storage relative to OptMAVEn. Testing on 54 additional antigens revealed that computational resource requirements of OptMAVEn-2.0 scale only sub-linearly with respect to antigen size. OptMAVEn-2.0 was used to design and rank variable antibody fragments targeting five epitopes of Zika envelope protein and three of hen egg white lysozyme. Among the top five ranked designs for each epitope, recovery of native residue identities is typically 45–65%. MD simulations of two designs targeting Zika suggest that at least one would bind with high affinity. OptMAVEn-2.0 can be downloaded from our GitHub repository and webpage as (links in Summary and Discussion section).
A Mesh-Free Particle Method for Simulation of Mobile-Bed Behavior Induced by Dam Break
Authors: Kim Kyung Sung
Published: July 2018

The mesh-free particle method is the latest method in the computational fluid dynamics field. It has become well-known due to its application for simulating any kind of interface deformation and fragmentation, including large disturbance on the interface. In this study, the moving particle semi-implicit (MPS) method has been developed for multi-phase to simulate mobile (erodible)-bed under violent flows such as a dam break. In order to develop the MPS method, multi-phase particle interaction models including self-buoyancy and surface tension models were employed. All of the newly adopted particle interaction models were modified by the author. When fluids collide with the soil bed, the erodible bed can be liquefied. In this regard, polyethylene oxide (PEO) solution was used as a mobile bed. The water column captured by the gate collapsed after opening the gate, and it then propagated over a mobile bed. The mobile bed has various thicknesses based on corresponding experiments. Moreover, the dam break on an inclined tank was also simulated to investigate the swash uprush problem. The maximum velocity and height of mixed flows were measured at a certain point, which aligned with the corresponding experiment. All of the simulation results were compared with those obtained from some experimental work.
Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges
Authors: Pilla Lorenzo , Maccalli Cristina
Published: July 2018

The recent advances in immunotherapy and the availability of novel drugs to target the tumor microenvironment have dramatically changed the paradigm of cancer treatment. Nevertheless, a significant proportion of cancer patients are unresponsive or develop resistance to these treatments. With the aim to increase the clinical efficacy of immunotherapy, combinations of agents and standard therapies with complementary actions have been developed mostly on an empirical base, since their mechanisms of actions are not yet fully dissected. The characterization of immune responsiveness and its monitoring along with the treatment of cancer patients with immunotherapy can provide insights into the mechanisms of action of these therapeutic regimens and contribute to the optimization of patients’ stratification and of combination strategies and to the prediction of treatment-related toxicities. Thus far, none of the immunomonitoring strategies has been validated for routine clinical practice. Moreover, it is becoming clear that the genomic and molecular make-up of tumors and of the infiltrating immune system represent important determinants of the clinical responses to immunotherapy. This review provides an overview of different approaches for the immune profiling of cancer patients and discusses their advantages and limitations. Recent advances in genomic-based assays and in the identification of host genomic relationships with immune responses represent promising approaches to identify molecular determinants and biomarkers to improve the clinical efficacy of cancer immunotherapy.
CUBIT: Capacitive qUantum BIT
Authors: Khorasani Sina
Published: July 2018

In this letter, it is proposed that cryogenic quantum bits can operate based on the nonlinearity due to the quantum capacitance of two-dimensional Dirac materials, and in particular graphene. The anharmonicity of a typical superconducting quantum bit is calculated, and the sensitivity of quantum bit frequency and anharmonicity with respect to temperature are found. Reasonable estimates reveal that a careful fabrication process can reveal expected properties, putting the context of quantum computing hardware into new perspectives.
Chiral Dirhodium(II) Carboxylates: New Insights into the Effect of Ligand Stereo-Purity on Catalyst Structure and Enantioselectivity
Authors: Adly Frady G. , Bollard Hannah , Gardiner Michael G. , Ghanem Ashraf
Published: July 2018

The current report contributes to the understanding of the stereoselectivity of chiral dirhodium(II) carboxylate catalysts carrying N-protected tert-leucine ligands. Investigating the possible effect of ligand stereo-purity on catalyst structure and enantioselectivity was carried out. This was justified through a new X-ray crystal structure for Rh2(S,S,S,R-PTTL)4 diastereomer.