bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebral nitric oxide and mitochondrial function in patients suffering aneurysmal subarachnoid hemorrhage—a translational approach
Authors: Hosmann Arthur , Milivojev Nadja , Dumitrescu Sergiu , Reinprecht Andrea , Weidinger Adelheid , Kozlov Andrey V.
Published: August 2020

Background

Cerebral ischemia and neuroinflammation following aneurysmal subarachnoid hemorrhage (SAH) are major contributors to poor neurological outcome. Our study set out to investigate in an exploratory approach the interaction between NO and energy metabolism following SAH as both hypoxia and inflammation are known to affect nitric oxide (NO) metabolism and NO in turn affects mitochondria.

Methods

In seven patients under continuous multimodality neuromonitoring suffering poor-grade aneurysmal SAH, cerebral metabolism and NO levels (determined as a sum of nitrite plus nitrate) were determined in cerebral microdialysate for 14 days following SAH. In additional ex vivo experiments, rat cortex homogenate was subjected to the NO concentrations determined in SAH patients to test whether these NO concentrations impair mitochondrial function (determined by means of high-resolution respirometry).

Results

NO levels showed biphasic kinetics with drastically increased levels during the first 7 days (74.5 ± 29.9 μM) and significantly lower levels thereafter (47.5 ± 18.7 μM; p = 0.02). Only during the first 7 days, NO levels showed a strong negative correlation with brain tissue oxygen tension (r = − 0.78; p < 0.001) and a positive correlation with cerebral lactate (r = 0.79; p < 0.001), pyruvate (r = 0.68; p < 0.001), glutamate (r = 0.65; p < 0.001), as well as the lactate-pyruvate ratio (r = 0.48; p = 0.01), suggesting mitochondrial dysfunction. Ex vivo experiments confirmed that the increase in NO levels determined in patients during the acute phase is sufficient to impair mitochondrial function (p < 0.001). Mitochondrial respiration was inhibited irrespectively of whether glutamate (substrate of complex I) or succinate (substrate of complex II) was used as mitochondrial substrate suggesting the inhibition of mitochondrial complex IV. The latter was confirmed by direct determination of complex IV activity.

Conclusions

Exploratory analysis of our data suggests that during the acute phase of SAH, NO plays a key role in the neuronal damage impairing mitochondrial function and facilitating accumulation of mitochondrial substrate; further studies are required to understand mechanisms underlying this observation.
Do different cone beam computed tomography exposure protocols influence subjective image quality prior to and after root canal treatment?
Authors: Yeung Andy Wai Kan , Harper Basak , Zhang Chengfei , Neelakantan Prasanna , Bornstein Michael M.
Published: August 2020

Objectives

The current study aimed to evaluate different CBCT exposure protocols and influencing factors affecting the subjective image quality of scans taken for endodontic indications.

Materials and methods

Twelve extracted teeth, comprising of two sets of maxillary molars, premolars, canines and incisors, mandibular premolars, and molars, were endodontically treated, and either received a fiber or metal post. The teeth were scanned by CBCT imaging before and after root canal treatment, and after post insertion. Each scan was performed thrice, using an ultra low dose (ULD), standard (SM), and high-resolution mode (HR), respectively. Twelve observers—4 endodontists, 4 periodontists, and 4 radiologists—assessed the subjective image quality using visual analogue scales (VAS). Potential influencing factors were evaluated including acquisition mode, observer specialty, stage of treatment, type of post, and type of tooth, using one-way ANOVA and T test.

Results

Teeth scanned with the ULD had the highest average VAS score (72.5), followed by HR (70.2), and SM (69.0) for values pooled from all teeth and observers. CBCT acquisition mode was not a significant influencing factor on the VAS scores. Observer specialty, stage of treatment, type of post, and type of tooth were significant influencing factors.

Conclusions

Based on the present in vitro data, a low-dose CBCT mode seems not to negatively affect the perception of image quality.

Clinical relevance

The findings from this in vitro study demonstrate that a low-dose CBCT mode might have potential for diagnostics prior to or following endodontic treatment.
Long-term complications and implant survival rates after cranioplastic surgery: a single-center study of 392 patients
Authors: Giese Henrik , Meyer Jennifer , Unterberg Andreas , Beynon Christopher
Published: August 2020

Cranioplasty (CP) is a standard procedure in neurosurgical practice for patients after (decompressive) craniectomy. However, CP surgery is not standardized, is carried out in different ways, and is associated with considerable complication rates. Here, we report our experiences with the use of different CP materials and analyze long-term complications and implant survival rates. We retrospectively studied patients who underwent CP surgery at our institution between 2004 and 2014. Binary logistic regression analysis was performed in order to identify risk factors for the development of complications. Kaplan-Meier analysis was used to estimate implant survival rates. A total of 392 patients (182 females, 210 males) with a mean age of 48 years were included. These patients underwent a total of 508 CP surgeries. The overall complication rate of primary CP was 33.2%, due to bone resorption/loosening (14.6%) and graft infection (7.9%) with a mean implant survival of 120 ± 5 months. Binary logistic regression analysis showed that young age (< 30 years) (p = 0.026, OR 3.150), the presence of multidrug-resistant bacteria (p = 0.045, OR 2.273), and cerebrospinal fluid (CSF) shunt (p = 0.001, OR 3.137) were risk factors for postoperative complications. The use of titanium miniplates for CP fixation was associated with reduced complication rates and bone flap osteolysis as well as longer implant survival rates. The present study highlights the risk profile of CP surgery. Young age (< 30 years) and shunt-dependent hydrocephalus are associated with postoperative complications especially due to bone flap autolysis. Furthermore, a rigid CP fixation seems to play a crucial role in reducing complication rates.
What You Get is What You See: Other-Rated but not Self-Rated Leaders’ Narcissistic Rivalry Affects Followers Negatively
Authors: Fehn Theresa , Schütz Astrid
Published: August 2020

Individuals with high levels of narcissism often ascend to leadership positions. Whereas there is evidence that narcissism is linked to unethical behavior and negative social outcomes, the effects of leader narcissism on an organization’s most important resource—its employees—have not yet been studied thoroughly. Using theoretical assumptions of the Narcissistic Admiration and Rivalry Concept (NARC) and social exchange theories, we examined how leaders’ narcissistic rivalry was related to follower outcomes in a sample of matched leaders and followers. Followers of leaders high in narcissistic rivalry reported less perceived supervisor support, lower quality leader-member relationships, lower performance-based self-esteem, and lower job engagement. These effects were only found when follower-rated leaders’ narcissistic rivalry was used in the model but not when self-rated leaders’ narcissistic rivalry was used as a predictor. This implies that the negative effects of leaders’ narcissistic rivalry on followers are driven by the expression of narcissistic tendencies (i.e., destructive leader behavior). Leader development should thus focus on changing destructive leader behavior. We propose that leaders high in narcissistic rivalry can be motivated to make such changes by showing them that by hurting their followers, they will eventually undermine their own reputation and status. Furthermore, selection and promotion practices should incorporate objective measures to weaken the effects of narcissists’ self-promotional tactics in these contexts and thus prevent people high in narcissistic rivalry from rising to leadership positions.
The PAX Good Behavior Game: One Model for Evolving a More Nurturing Society
Authors: Johansson Magnus , Biglan Anthony , Embry Dennis
Published: August 2020

This paper describes the culture and components of the PAX Good Behavior Game and offers it as one model for how to enhance the well-being of populations through the diffusion of nurturing practices into several venues of society. The PAX components, also known as evidence-based kernels, are proposed to be useful in classrooms, families, organizations, criminal justice, and in improving public discussion and government. Kernels affect behavior in the short- and long-term through combinations of antecedents, reinforcers, relational networks, and physiological effects. Identifying common strategies, tools, and clear targets of change is suggested as a way to work towards evolving freely available evidence-based tools that can be combined to improve social conditions in multiple contexts.
From laboratory to field: applying the Fo47 biocontrol strain in potato fields
Authors: Constantin Maria E. , de Lamo Francisco J. , Rep Martijn , Takken Frank L. W.
Published: August 2020

Endophytic microbes conferring biocontrol are an eco-friendly alternative to control diseases in crops. Unfortunately, the use of endophytes to control diseases is not yet widespread as their application in agricultural settings is challenging and the outcome variable. Translating strains that perform well under laboratory conditions to the field poses several challenges. One is large scale inoculum production in a cost-effective manner. Here, we developed a framework to scale up inoculum production of Fusarium oxysporum 47 (Fo47), assess inoculum viability and its performance in the field and effects on potato yield and performance. The Fo47 endophyte is a well-described biocontrol agent, isolated from disease suppressive soils in the 1980’s. Using mung bean medium, we could routinely produce ≈7 × 108 spores/mL. Using 60 mL of 107 spores/mL per tuber we could re-isolate the fungus 79 days after application from 60 to 70% of the inoculated plants in a large-scale potato field trial (Clenze, Germany). Furthermore, this protocol can be used to assess Fo47 biocontrol potential under field conditions. The presence of the fungus did not negatively affect plant yield or starch production and did not increase susceptibility to endemic pathogens.
Interaction Analysis as an Embodied and Interactive Process: Multimodal, Co-operative, and Intercorporeal Ways of Seeing Video Data as Complementary Professional Visions
Authors: Katila Julia , Raudaskoski Sanna
Published: August 2020

The analysis of video-recorded interaction consists of various professionalized ways of seeing participant behavior through multimodal, co-operative, or intercorporeal lenses. While these perspectives are often adopted simultaneously, each creates a different view of the human body and interaction. Moreover, microanalysis is often produced through local practices of sense-making that involve the researchers’ bodies. It has not been fully elaborated by previous research how adopting these different ways of seeing human behavior influences both what is seen from a video and how it is seen, as well as the way the interpretation of the data ultimately unfolds in the interaction between researchers. In this article, we provide a theoretical-methodological discussion of the microanalytic research process. We explore how it differs from “seeing” affect in interaction either as a co-operative and multimodal action or as an intercorporeal experience. First, we introduce the multimodal conversation analytic, co-operative, and intercorporeal approaches to microanalysis. Second, we apply and compare these practices to a video-recorded interaction of a romantic couple. Furthermore, we examine a video-recorded episode of us, the researchers, reflecting on our analytic observations about this interaction. We suggest that adopting a multimodal and co-operative perspective constructs affect as co-produced and displayed through observable action, while an intercorporeal perspective produces affect as an embodied and experienced phenomenon. While the former enables locating affect in a specific moment and identifiable body parts, the latter facilitates recognizing the experienced side of affect. These different modes of professional vision complement one another in capturing affect in interaction while being fundamentally used in local interactions between the researchers.
On Solvability of Integro-Differential Equations
Authors: De León-Contreras Marta , Gyöngy István , Wu Sizhou
Published: August 2020

A class of (possibly) degenerate integro-differential equations of parabolic type is considered, which includes the Kolmogorov equations for jump diffusions. Existence and uniqueness of the solutions are established in Bessel potential spaces and in Sobolev-Slobodeckij spaces. Generalisations to stochastic integro-differential equations, arising in filtering theory of jump diffusions, will be given in a forthcoming paper.
How to run a sustainability science research group sustainably?
Authors: Plieninger Tobias , Fagerholm Nora , Bieling Claudia
Published: August 2020

Rigorous sustainability science includes addressing pressing real-world problems, weaving multiple knowledge systems, and striving for transformative change. However, these key attributes of sustainability science often conflict with university structures and established academic work practices, for instance with regard to frequent long-distance travel. Such contradictions between key principles of sustainability and everyday practices are experienced by many researchers not only at university level, but also in their individual behaviors. To help resolve this widespread divergence, we present ten principles to foster the sustainability of a research group working in sustainability science, based on our personal experiences and experiments as research group leaders. These principles comprise: (1) monitor the environmental footprint, (2) foster learning and innovation, (3) reduce the environmental footprint, (4) nurture campus sustainability, (5) embrace sustainability in private life, (6) constructively deal with environmental anxiety, (7) design research projects for sustainability impact, (8) engage with stakeholders, (9) capitalize on sustainability teaching, and (10) recognize biases and limits. Applying sustainability principles in everyday research practices can provide important social tipping points that may trigger the spreading of new social norms and behaviors.
Applying a Precautionary Approach to Mobile Contact Tracing for COVID-19: The Value of Reversibility
Authors: Nijsingh Niels , van Bergen Anne , Wild Verina
Published: August 2020

The COVID-19 pandemic presents unprecedented challenges to public health decision-making. Specifically, the lack of evidence and the urgency with which a response is called for, raise the ethical challenge of assessing how much (and what kind of) evidence is required for the justification of interventions in response to the various threats we face. Here we discuss the intervention of introducing technology that aims to trace and alert contacts of infected persons—contact tracing (CT) technology. Determining whether such an intervention is proportional is complicated by complex trade-offs and feedback loops. We suggest that the resulting uncertainties necessitate a precautionary approach. On the one hand, precautionary reasons support CT technology as a means to contribute to the prevention of harms caused by alternative interventions, or COVID-19 itself. On the other hand, however, both the extent to which such technology itself present risks of serious harm, as well as its effectiveness, remain unclear. We therefore argue that a precautionary approach should put reversibility of CT technology at the forefront. We outline several practical implications.
COVID-19 and Contact Tracing Apps: Ethical Challenges for a Social Experiment on a Global Scale
Authors: Lucivero Federica , Hallowell Nina , Johnson Stephanie , Prainsack Barbara , Samuel Gabrielle , Sharon Tamar
Published: August 2020

Mobile applications are increasingly regarded as important tools for an integrated strategy of infection containment in post-lockdown societies around the globe. This paper discusses a number of questions that should be addressed when assessing the ethical challenges of mobile applications for digital contact-tracing of COVID-19: Which safeguards should be designed in the technology? Who should access data? What is a legitimate role for “Big Tech” companies in the development and implementation of these systems? How should cultural and behavioural issues be accounted for in the design of these apps? Should use of these apps be compulsory? What does transparency and ethical oversight mean in this context? We demonstrate that responses to these questions are complex and contingent and argue that if digital contract-tracing is used, then it should be clear that this is on a trial basis and its use should be subject to independent monitoring and evaluation.
Pandemic Surveillance and Racialized Subpopulations: Mitigating Vulnerabilities in COVID-19 Apps
Authors: Hendl Tereza , Chung Ryoa , Wild Verina
Published: August 2020

Debates about effective responses to the COVID-19 pandemic have emphasized the paramount importance of digital tracing technology in suppressing the disease. So far, discussions about the ethics of this technology have focused on privacy concerns, efficacy, and uptake. However, important issues regarding power imbalances and vulnerability also warrant attention. As demonstrated in other forms of digital surveillance, vulnerable subpopulations pay a higher price for surveillance measures. There is reason to worry that some types of COVID-19 technology might lead to the employment of disproportionate profiling, policing, and criminalization of marginalized groups. It is, thus, of crucial importance to interrogate vulnerability in COVID-19 apps and ensure that the development, implementation, and data use of this surveillance technology avoids exacerbating vulnerability and the risk of harm to surveilled subpopulations, while maintaining the benefits of data collection across the whole population. This paper outlines the major challenges and a set of values that should be taken into account when implementing disease surveillance technology in the pandemic response.
Comparison of diffusion tube–measured nitrogen dioxide concentrations at child and adult breathing heights: who are we monitoring for?
Authors: Rowell Alex , Terry Michael E. , Deary Michael E.
Published: August 2020

Many towns and cities use passive samplers (diffusion tubes) to monitor nitrogen dioxide (NO2) concentration. However, literature studies have shown large horizontal and vertical concentration gradients for diffusion tubes placed over short distances, raising concerns over the representativeness of monitoring locations. This study examines variations in NO2 concentrations with height at two roadside locations along a busy urban road in Newcastle upon Tyne (UK) over an 8-month period. NO2 concentrations were passively monitored at building facades (approximately 7.0 m from the roadside) at heights of 0.7 m, 1.7 m and 2.7 m to replicate child breathing height in prams and buggies, adult breathing height and the Newcastle City Council sampling height (for 2017), respectively. Paired t tests indicated that NO2 concentrations were significantly lower at 2.7 m (4.7% lower, n = 16, p = 0.001) and 1.7 m (7.1% lower, n = 14, p = 0.007) compared with those at 0.7 m. There was no statistically significant difference between NO2 concentrations measured at 2.7 m and 1.7 m, indicating that UK local authority practice of placing diffusion tubes at higher than adult breathing height does not result in underreporting of NO2 concentrations for regulatory purposes. The results have clear public health implications as they provide evidence that young children, in an urban setting and close to busy roadways, may be exposed to higher NO2 concentrations compared with adults in the same location. We have shown that such differences might not be adequately reflected in the monitoring data from municipal authorities.
Early Onset of Autoimmune Diabetes in Children with Down Syndrome—Two Separate Aetiologies or an Immune System Pre-Programmed for Autoimmunity?
Authors: Mortimer Georgina L. , Gillespie Kathleen M.
Published: August 2020

Purpose of Review

An increased frequency of autoimmunity in children with Down syndrome (DS) is well described but few studies have investigated the underlying mechanisms. Recent immune system investigation of individuals with DS may shed light on the increased risk of autoimmune conditions including type 1 diabetes.

Recent Findings

Diagnosis of type 1 diabetes is accelerated in children with DS with 17% diagnosed at, or under, the age of 2 years compared with only 4% in the same age group in the general population. Counterintuitively, children with DS and diabetes have less human leukocyte antigen (HLA)-mediated susceptibility than age-matched children with autoimmune diabetes from the general population. Early onset of diabetes in DS is further highlighted by the recent description of neonatal cases of diabetes which is autoimmune but not HLA associated. There are two potential explanations for this accelerated onset: (1) an additional chromosome 21 increases the genetic and immunological risk of autoimmune diabetes or (2) there are two separate aetiologies in children with DS and diabetes.

Autoimmunity in DS is an under-investigated area. In this review, we will draw on recent mechanistic studies in individuals with DS which shed some light on the increased risk of autoimmunity in children with DS and consider the current support for and against two aetiologies underlying diabetes in children with DS.
Haemodynamics of Hypertension in Children
Authors: Li Ye , Haseler Emily , Chowienczyk Phil , Sinha Manish D.
Published: August 2020

Purpose of Review

To review the haemodynamic characteristics of paediatric hypertension.

Recent Findings

Pulsatile components of blood pressure are determined by left ventricular dynamics, aortic stiffness, systemic vascular resistance and wave propagation phenomena. Recent studies delineating these factors have identified haemodynamic mechanisms contributing to primary hypertension in children.

Studies to date suggest a role of cardiac over activity, characterized by increased heart rate and left ventricular ejection, and increased aortic stiffness as the main haemodynamic determinants of primary hypertension in children.
Effects on primary energy use, greenhouse gas emissions and related costs from improving energy end-use efficiency in the electrolysis in primary aluminium production
Authors: Haraldsson Joakim , Johansson Maria T.
Published: August 2020

Primary aluminium production is energy- and GHG-intensive in which electrolysis is by far the most energy- and GHG-intensive process. This paper’s aim is to study the effects on (1) primary energy use, (2) GHG emissions and (3) energy and CO2 costs when energy end-use efficiency measures are implemented in the electrolysis. Significant savings in final and primary energy use, GHG emissions and energy and CO2 costs can be achieved by implementing the studied measures. Vertical electrode cells and the combination of inert anodes and wettable cathodes are among the measures with the highest savings in all three areas (primary energy use, GHG emissions and energy and CO2 costs). Direct carbothermic reduction is one of the measures with the highest savings in primary energy use and energy and CO2 costs. For GHG emissions, direct carbothermic reduction is the more beneficial choice in regions with a high proportion of coal power, while inert anodes are the more beneficial choice in regions with a high proportion of low-carbon electricity. Although a company potentially can save more money by implementing the direct carbothermic reduction, the company should consider implementing the vertical electrode cells together with other energy-saving technologies since this would yield the largest GHG emission savings while providing similar cost savings as the direct carbothermic reduction. It may be necessary to impose a price on GHG emissions in order to make inert anodes cost-effective on their own, although further evaluations are needed in this regard. There is a potential to achieve carbon-neutrality in the reduction of aluminium oxide to pure aluminium.
Weak transitivity and agenda control for extended stepladder tournaments
Authors: Yang Yongjie , Dimitrov Dinko
Published: August 2020

A tournament graph over n players is weakly transitive at player p if it contains a Hamiltonian path $$\left( p_{1},p_{2}, \dots , p_{n}\right) $$

p
1

,

p
2

,
⋯
,

p
n

with $$ p_{1}=p$$

p
1

=
p

such that for all odd integers $$i\le n-2$$

i
≤
n
-
2

there is an arc from $$p_{i}$$

p
i

to $$p_{i+2}$$

p

i
+
2

. We show that weak transitivity at p suffices to make player p win any extended stepladder tournament of degree at most two.
Accident and hazard prediction models for highway–rail grade crossings: a state-of-the-practice review for the USA
Authors: Abioye Olumide F. , Dulebenets Maxim A. , Pasha Junayed , Kavoosi Masoud , Moses Ren , Sobanjo John , Ozguven Eren E.
Published: August 2020

Highway–rail grade crossings (HRGCs) are one of the most dangerous segments of the transportation network. Every year numerous accidents are recorded at HRGCs between highway users and trains, between highway users and traffic control devices, and solely between highway users. These accidents cause fatalities, severe injuries, property damage, and release of hazardous materials. Researchers and state Departments of Transportation (DOTs) have addressed safety concerns at HRGCs in the USA by investigating the factors that may cause accidents at HRGCs and developed certain accident and hazard prediction models to forecast the occurrence of accidents and crossing vulnerability. The accident and hazard prediction models are used to identify the most hazardous HRGCs that require safety improvements. This study provides an extensive review of the state-of-the-practice to identify the existing accident and hazard prediction formulae that have been used over the years by different state DOTs. Furthermore, this study analyzes the common factors that have been considered in the existing accident and hazard prediction formulae. The reported performance and implementation challenges of the identified accident and hazard prediction formulae are discussed in this study as well. Based on the review results, the US DOT Accident Prediction Formula was found to be the most commonly used formula due to its accuracy in predicting the number of accidents at HRGCs. However, certain states still prefer customized models due to some practical considerations. Data availability and data accuracy were identified as some of the key model implementation challenges in many states across the country.
A novel entropy-based weighted attribute selection in enhanced multicriteria decision-making using fuzzy TOPSIS model for hesitant fuzzy rough environment
Authors: Dikshit-Ratnaparkhi Archana , Bormane Dattatraya , Ghongade Rajesh
Published: August 2020

The existing approaches of multicriteria decision-making (MCDM) process might yield unreliable and questionable results. The notable challenges of MCDM approaches are rank reversal paradox and uncertainty. The prime inspiration for researchers is the MCDM for hesitant fuzzy sets (HFSs). In some scenarios, the decision-makers could not choose one from numerous values while expressing their preferences. HFS which is the extension of fuzzy sets (FS) is found to be helpful in solving such decision-making (DM) problems. The DM process is revolutionized with the commencement of powerful and efficient tools of data representation for expressing vagueness and uncertainty in data sets as FSs (both generalized and hesitant ones). This paper copes with one such novel approach that involves entropy-based attribute weighting, followed by an evaluation of approximate sets in the fuzzy rough framework. Correlation of the input alternatives in respect of evaluation criteria and the output class is evaluated. With the fuzzy technique for ordered preference by similarity to ideal solutions (FTOPSIS), the generated correlation matrix is utilized for calculating the degree of closeness ($$ \delta $$
δ
) of the output classes to the input alternatives. This paper made a novel contribution of performance indicator centered on FTOPSIS for the hesitant fuzzy rough domain. The proposed method’s efficiency is established through comprehensive and systematic experimentation on datasets utilized by researchers globally. The proposed algorithms prove its ability to handle datasets that involve human-like hesitant thinking in the MCDM system by contrasting with the existing ones.
Plasmonic Ag-Decorated Few-Layer MoS2 Nanosheets Vertically Grown on Graphene for Efficient Photoelectrochemical Water Splitting
Authors: Seo Dong-Bum , Trung Tran Nam , Kim Dong-Ok , Duc Duong Viet , Hong Sungmin , Sohn Youngku , Jeong Jong-Ryul , Kim Eui-Tae
Published: August 2020

A controllable approach that combines surface plasmon resonance and two-dimensional (2D) graphene/MoS2 heterojunction has not been implemented despite its potential for efficient photoelectrochemical (PEC) water splitting. In this study, plasmonic Ag-decorated 2D MoS2 nanosheets were vertically grown on graphene substrates in a practical large-scale manner through metalorganic chemical vapor deposition of MoS2 and thermal evaporation of Ag. The plasmonic Ag-decorated MoS2 nanosheets on graphene yielded up to 10 times higher photo-to-dark current ratio than MoS2 nanosheets on indium tin oxide. The significantly enhanced PEC activity could be attributed to the synergetic effects of SPR and favorable graphene/2D MoS2 heterojunction. Plasmonic Ag nanoparticles not only increased visible-light and near-infrared absorption of 2D MoS2, but also induced highly amplified local electric field intensity in 2D MoS2. In addition, the vertically aligned 2D MoS2 on graphene acted as a desirable heterostructure for efficient separation and transportation of photo-generated carriers. This study provides a promising path for exploiting the full potential of 2D MoS2 for practical large-scale and efficient PEC water-splitting applications.
Assessing Future Changes of Climate Extreme Events in the CORDEX-MENA Region Using Regional Climate Model ALADIN-Climate
Authors: Driouech Fatima , ElRhaz Khalid , Moufouma-Okia Willfran , Arjdal Khadija , Balhane Saloua
Published: August 2020

This study investigates future changes of temperature, precipitation, and associated extreme events in the MENA region using Regional Climate Model ALADIN-Climate over the CORDEX-MENA domain. Model capabilities to reproduce key observed regional climate features are first assessed, including heat waves, drought and high precipitation extremes. Projected changes indicate the intensification of heat waves number, duration and magnitude, and contrasted precipitation changes. A drying is projected in the north-west and moistening in the north-east along the Mediterranean side of the region. Projected regional warming is found at the rate of about 0.2 °C/decade to 0.5 °C/decade over land depending on the scenario. Drought is expected to increase in the northern half of the region independently from the index used, but with a higher rate in the case of the index accounting for both the effect of precipitation and temperature changes. ALADIN-Climate results corroborate previous studies projecting the MENA region to host global hot spots for drought in the late twenty-first century.
Pregnancy Outcomes of Single/Double Blastocysts and Cleavage Embryo Transfers: a Retrospective Cohort Study of 24,422 Frozen-Thawed Cycles
Authors: Long Xiaoyu , Wang Yuanyuan , Wu Fangrong , Li Rong , Chen Lixue , Qian Weiping , Qiao Jie
Published: August 2020

This study aims to evaluate the effect of blastocyst- and cleavage-stage embryo transfers with different numbers of transferred embryos on pregnancy outcomes in China. This was a retrospective cohort study that collected 24,422 frozen-thawed embryo transfer (FET) cycles in two affiliated hospitals of Peking University Health Science Center between January 2015 and May 2018. They were divided into four groups: the single cleavage-stage embryo transfer group (C-1) (763 cycles), double cleavage-stage embryo transfer group (C-2) (13,004 cycles), single blastocyst-stage embryo transfer group (B-1) (7913 cycles), and double blastocyst-stage embryo transfer group (B-2) (2046 cycles). Of the four groups, the live birth rate was the lowest in the C-1 group (11.8%) while it was the highest in the B-2 group (33.6%). However, the B-2 group was accompanied with higher risks of miscarriages, maternal complications, twin births, preterm births, and low birth weight. Compared with the C-2 group, the B-1 group had a lower live birth rate (23.0 vs 29.0%; aOR, 0.78; 95% CI, 0.72–0.85), but also had a lower risk for twin births (1.9 vs 23.4%; aOR, 0.06; 95% CI, 0.04–0.09) and preterm births (9.6 vs 16.1%; aOR, 0.51; 95% CI, 0.41–0.65). The probability of live birth in the B-1 group declined from 0.25 at 20–29 years old to 0.08 at > 40 years old, while the probabilities of adverse outcomes went up with maternal age. It can be concluded that single-blastocyst embryo transfer seems to be the best choice for all maternal ages. This group of embryo transfer has significantly reduced adverse neonatal outcomes. Especially, women with younger maternal age in this group appear to prominently benefit from single-blastocyst transfer.
Susceptibility to prosocial and antisocial influence in adolescence
Authors: Ahmed S. , Foulkes L. , Leung J.T. , Griffin C. , Sakhardande A. , Bennett M. , Dunning D.L. , Griffiths K. , Parker J. , Kuyken W. , Williams J.M.G. , Dalgleish T. , Blakemore S.J.
Published: August 2020

Introduction

Adolescents are particularly susceptible to social influence and previous studies have shown that this susceptibility decreases with age. The current study used a cross‐sectional experimental paradigm to investigate the effect of age and puberty on susceptibility to both prosocial and antisocial influence.

Methods

Participants (N = 520) aged 11–18 from London and Cambridge (United Kingdom) rated how likely they would be to engage in a prosocial (e.g. “help a classmate with their work”) or antisocial (e.g. “make fun of a classmate”) act. They were then shown the average rating (in fact fictitious) that other adolescents had given to the same question, and were then asked to rate the same behaviour again.

Results

Both prosocial and antisocial influence decreased linearly with age, with younger adolescents being more socially influenced when other adolescents’ ratings were more prosocial and less antisocial than their own initial rating. Both antisocial and prosocial influence significantly decreased across puberty for boys but not girls (independent of age).

Conclusions

These findings suggest that social influence declines with increasing maturity across adolescence. However, the exact relationship between social influence and maturity is dependent on the nature of the social influence and gender. Understanding when adolescents are most susceptible to different types of social influence, and how this might influence their social behaviour, has important implications for understanding adolescent social development.
Optimization of hot-water ice-coring drills
Authors: Liu An , Wang Rusheng , Yang Yang , Wang Liang , Li Xiao , Li Yazhou , Talalay Pavel
Published: August 2020

Hot-water ice-coring drills are often used to recover ice core samples from desirable depths in conjunction with full-scale hot-water drilling systems. However, the recovered cores exhibit varying qualities. The coring performance of a hot-water ice-coring drill depends significantly on the structure of the coring drill head (nozzle angle, diameter and number). To discover the most significant factor affecting ice-coring performance, nine types of drill heads were designed and tested in this study according to the orthogonal test design. Results indicated that the nozzle angle is the most significant factor that affects the coring quality and the optimal angle is ~15°. The number of nozzles is the second most important factor; a large number assists in obtaining ice cores of high quality. The optimal nozzle configuration to recover good quality cores are the following: the nozzle diameter, number of nozzles and nozzle angle are 1 mm, 60 nozzles and 15°, respectively, with the maximum diameter and 2 mm, 60 nozzles and 15°, respectively, with the maximum length.
Incorporating professional recommendations into a graduate-level statistical consulting laboratory: A case study
Authors: Sima Adam P. , Rodriguez Viviana A. , Bradbrook Keighly E. , DiPace Brian S. , Okhomina Victoria
Published: August 2020

Introduction:

There has been a recent trend in medical research towards a more collaborative relationship between statisticians and clinical investigators. This has led to an increased focus on the most efficient and effective ways to structure, conduct, and measure the impact of organizations that provide statistical services to clinical investigators. Several recent guidelines and recommendations on the conduct of statistical consulting services(SCSs) have been made in response to this need, focusing on larger SCSs consisting primarily of faculty and staff statisticians. However, the application of these recommendations to consulting services primarily staffed by graduate students, which have the dual role of providing a professional service and training, remains unclear.

Methods:

Guidelines and recommendations, primarily from the Clinical and Translational Science (CTSA) consortium, were applied to a SCS staffed primarily by graduate students in an academic health center. A description of the organizational structure and outcomes after 3 years of operation is presented.

Results:

The guidelines recommended by the CTSA consortium and other groups were successfully incorporated into the graduate consulting laboratory. At almost one new project request per week, the consulting laboratory demonstrated a large bandwidth and had an excellent feedback from investigators.

Conclusions:

Guidelines developed for larger statistical consulting organizations are able to be applied in student-led consultation organizations. Outcomes and recommendations from 3.5 years of operation are used to describe the successes and challenges we have encountered.
National Identity for Breakfast: Food Consumption and the Everyday Construction of National Narratives in Estonia
Authors: Polese Abel , Seliverstova Oleksandra , Kerikmae Tanel , Cheskin Ammon
Published: August 2020

Political debates on the Baltics, and in particular Estonia, have often pointed to “nationalisting” and exclusive narratives constructed at the institutional level. Accordingly, emphasis has been put on the lack of opportunities for Russians to integrate into an Estonian context. While acknowledging the shortfalls of the Estonian political project, this article contrasts these views in two ways. By emphasizing people’s agency and their capacity to question, contrast, or even reject the identity markers proposed by Estonian official narratives, we maintain that the integration of Russians might be more advanced than insofar claimed by other studies. We then look at the way identities are lived in an everyday context by inhabitants of Estonia to counterpose national narratives proposed by the state and its political institutions, with the way people live and whether they accept these narratives. By doing this, we explore the role of the everyday in the reconstruction of national identity narratives, in which citizens actively participate in their individual capacity. We suggest that, from a James Scott “infrapolitics” perspective, these micro-actions have a fundamental role in the reshaping of a national identity and its acceptance among citizens.
THE NATURE OF THE HALLSTATTIAN CULTURAL CHANGE IN NORTHERN CENTRAL EUROPE IN LIGHT OF RADIOCARBON DATING OF THE LATE BRONZE AGE STRONGHOLD AT ŁUBOWICE NEAR RACIBÓRZ (SOUTHWEST POLAND)
Authors: Chochorowski Jan , Krąpiec Marek
Published: August 2020

At the close of the Bronze Age, a tendency developed in Central Europe towards the concentration of settlement and fortification of sites which served special economic and social functions. One of the largest centers of this kind in the northern part of Central Europe is the Łubowice stronghold (SW Poland). Archaeological excavations allowed the stratigraphy of the fortification remnants to be comprehensively investigated. In their final stage, these fortifications comprised of a monumental earthen rampart with timber structures, which were later destroyed in a violent fire. Originally, the destruction of the Łubowice stronghold was linked with the raids by nomadic Scythians and dated to the first half of the 6th century BC. However, radiocarbon analyses of charcoal from the burned rampart relics have shown that the destruction of the fortifications took place in the 9th century BC. The new dating of the moment when the Łubowice fortifications was burned down, i.e. “shortly after 845–802 cal BC” places this event within historical processes which reshaped the cultural picture in much of Central Europe at the dawn of the Iron Age. The spreading of a new, Hallstatt cultural model was associated with deep changes in social structures.
Creditor Rights and Bank Loan Losses
Authors: Heitz Amanda Rae , Narayanamoorthy Ganapathi
Published: August 2020

We develop hypotheses regarding the association between two types of creditor rights and bank loan losses. Contrary to prior research conclusions, bank lending risk is negatively associated with both restrictions on reorganization and the secured creditor being paid first. Using accounting disclosures, we develop novel empirical measures of the probability of default (PD) and loss given default (LGD) at the loan-portfolio level. Different types of creditor rights have differential effects pertaining to PD and LGD and exhibit significant intertemporal variation. We corroborate our cross-country findings using the Bankruptcy Abuse Prevention and Consumer Protection Act (BAPCPA) shock to creditor rights.
Relationship between anosmia and hospitalisation in patients with coronavirus disease 2019: an otolaryngological perspective
Authors: Avcı H , Karabulut B , Farasoglu A , Boldaz E , Evman M
Published: August 2020

Objective

A study was carried out to evaluate the relationship between anosmia and hospital admission in coronavirus disease 2019 patients.

Methods

The clinical data of 1534 patients with confirmed coronavirus disease 2019 virus were analysed. The study was conducted with medical records of 1197 patients (78 per cent). The basic characteristics of patients and symptoms related to otolaryngology practice were examined. The patients were divided into two groups according to their follow up: an out-patient group and an in-patient group.

Results

The majority of patients presented with anosmia (44.2 per cent), dysgeusia (43.9 per cent) and fever (38.7 per cent). Anosmia was observed in 462 patients (47 per cent) in the out-patient group, and in only 67 patients (31.2 per cent) in the in-patient group. Younger age (odds ratio = 1.05, 95 per cent confidence interval = 1.03–1.06) and the presence of anosmia (odds ratio = 2.04, 95 per cent confidence interval = 1.39–3) were significantly related to out-patient treatment.

Conclusion

Anosmia could be a symptom in the clinical presentation of the coronavirus disease 2019 infection.
A randomized trial of aerobic exercise for major depression: examining neural indicators of reward and cognitive control as predictors and treatment targets
Authors: Brush C. J. , Hajcak Greg , Bocchine Anthony J. , Ude Andrew A. , Muniz Kristina M. , Foti Dan , Alderman Brandon L.
Published: August 2020

Background

Aerobic exercise has demonstrated antidepressant efficacy among adults with major depression. There is a poor understanding of the neural mechanisms associated with these effects. Deficits in reward processing and cognitive control may be two candidate targets and predictors of treatment outcome to exercise in depression.

Methods

Sixty-six young adults aged 20.23 years (s.d. = 2.39) with major depression were randomized to 8 weeks of moderate-intensity aerobic exercise (n = 35) or light stretching (n = 31). Depressive symptoms were assessed across the intervention to track symptom reduction. Reward processing [reward positivity (RewP)] and cognitive control [error-related negativity (ERN)] were assessed before and after the intervention using event-related brain potentials.

Results

Compared to stretching, aerobic exercise resulted in greater symptom reduction (gs = 0.66). Aerobic exercise had no impact on the RewP (gav = 0.08) or ERN (gav = 0.21). In the aerobic exercise group, individuals with a larger pre-treatment RewP [odds ratio (OR) = 1.45] and increased baseline depressive symptom severity (OR = 1.18) were more likely to respond to an aerobic exercise program. Pre-treatment ERN did not predict response (OR = 0.74).

Conclusions

Aerobic exercise is effective in alleviating depressive symptoms in adults with major depression, particularly for those with increased depressive symptom severity and a larger RewP at baseline. Although aerobic exercise did not modify the RewP or ERN, there is preliminary support for the utility of the RewP in predicting who is most likely to respond to exercise as a treatment for depression.
Mild cognitive impairment with Lewy bodies: neuropsychiatric supportive symptoms and cognitive profile
Authors: Donaghy Paul C , Ciafone Joanna , Durcan Rory , Hamilton Calum A , Barker Sally , Lloyd Jim , Firbank Michael , Allan Louise M , O'Brien John T , Taylor John-Paul , Thomas Alan J
Published: August 2020

Background

Recently published diagnostic criteria for mild cognitive impairment with Lewy bodies (MCI-LB) include five neuropsychiatric supportive features (non-visual hallucinations, systematised delusions, apathy, anxiety and depression). We have previously demonstrated that the presence of two or more of these symptoms differentiates MCI-LB from MCI due to Alzheimer's disease (MCI-AD) with a likelihood ratio >4. The aim of this study was to replicate the findings in an independent cohort.

Methods

Participants ⩾60 years old with MCI were recruited. Each participant had a detailed clinical, cognitive and imaging assessment including FP-CIT SPECT and cardiac MIBG. The presence of neuropsychiatric supportive symptoms was determined using the Neuropsychiatric Inventory (NPI). Participants were classified as MCI-AD, possible MCI-LB and probable MCI-LB based on current diagnostic criteria. Participants with possible MCI-LB were excluded from further analysis.

Results

Probable MCI-LB (n = 28) had higher NPI total and distress scores than MCI-AD (n = 30). In total, 59% of MCI-LB had two or more neuropsychiatric supportive symptoms compared with 9% of MCI-AD (likelihood ratio 6.5, p < 0.001). MCI-LB participants also had a significantly greater delayed recall and a lower Trails A:Trails B ratio than MCI-AD.

Conclusions

MCI-LB is associated with significantly greater neuropsychiatric symptoms than MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD, with greater executive and lesser memory impairment, but these differences are not sufficient to differentiate MCI-LB from MCI-AD.