bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomarkers for Assessing Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus on Sodium–Glucose Cotransporter 2 Inhibitor Therapy
Authors: Khaznadar Farah , Petrovic Ana , Khaznadar Omar , Roguljic Hrvoje , Bojanic Kristina , Kuna Roguljic Lucija , Siber Stjepan , Smolic Robert , Bilic-Curcic Ines , Wu George Y. , Smolic Martina
Published: October 2023

In the current modern era of unhealthy lifestyles, non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease and has become a serious global health problem. To date, there is no approved pharmacotherapy for the treatment of NAFLD, and necessary lifestyle changes such as weight loss, diet, and exercise are usually not sufficient to manage this disease. Patients with type 2 diabetes mellitus (T2DM) have a significantly higher risk of developing NAFLD and vice versa. Sodium–glucose cotransporter 2 (SGLT2) inhibitors are antidiabetic agents that have recently been approved for two other indications: chronic kidney disease and heart failure in diabetics and non-diabetics. They are also emerging as promising new agents for NAFLD treatment, as they have shown beneficial effects on hepatic inflammation, steatosis, and fibrosis. Studies in animals have reported favorable effects of SGLT2 inhibitors, and studies in patients also found positive effects on body mass index (BMI), insulin resistance, glucose levels, liver enzymes, apoptosis, and transcription factors. There are some theories regarding how SGLT2 inhibitors affect the liver, but the exact mechanism is not yet fully understood. Therefore, biomarkers to evaluate underlying mechanisms of action of SGLT2 inhibitors on the liver have now been scrutinized to assess their potential as a future in-label therapy for NAFLD. In addition, finding suitable non-invasive biomarkers could be helpful in clinical practice for the early detection of NAFLD in patients. This is crucial for a positive disease outcome. The aim of this review is to provide an overview of the most recent findings on the effects of SGLT2 inhibitors on NAFLD biomarkers and the potential of SGLT2 inhibitors to successfully treat NAFLD.
Predictors of Atrial Fibrillation in Patients with Embolic Stroke of Unknown Etiology and Implantable Loop Recorders—Further Insights of the TRACK AF Study on the Role of ECG and Echocardiography
Authors: Höwel Dennis , Leitz Patrick , Frommeyer Gerrit , Ritter Martin A. , Reinke Florian , Füting Anna , Reinsch Nico , Eckardt Lars , Kochhäuser Simon , Dechering Dirk G.
Published: October 2023

Aims—Electrocardiography (ECG) and echocardiographic left atrial (LA) parameters may be helpful to assess the risk of atrial fibrillation (AF) in embolic stroke of unknown etiology (ESUS) and could therefore guide intensity of ECG monitoring. Methods—1153 consecutive patients with ischemic stroke or transient ischemic attack (TIA) were analyzed. An internal loop recorder (ILR) was implanted in 104 consecutive patients with ESUS. Multiple morphologic P-wave parameters in baseline 12-channel ECG and echocardiographic LA parameters were measured and analyzed in patients with and without ILR-detected AF. Using logistic regression, we evaluated the predictive value of several ECG parameters and LA dimensions on the occurrence of AF. Results—In 20 of 104 (19%) patients, AF was diagnosed by ILR during a mean monitoring time of 575 (IQR 470–580) days. Patients with AF were significantly older (72 (67–75) vs. 60 (52–72) years; p = 0.001) and premature atrial contractions (PAC) were more frequently observed (40% vs. 2%; p < 0.001) during baseline ECG. All morphologic P-wave parameters did not show a significant difference between groups. There was a non-significant trend towards a larger LA volume index (31 (24–36) vs. 29 (25–37) mL/m2; p = 0.09) in AF patients. Conclusions—Age and PAC are independently associated with incident AF in ESUS and could be used as markers for selecting patients that may benefit from more extensive rhythm monitoring or ILR implantation. In our consecutive cohort of patients with ESUS, neither morphological P-wave parameters nor LA size were predictive of AF.
Efficacy and Risks of Different Treatments for Oral Hyperpigmentation: A Systematic Review and Network Meta-Analysis
Authors: Jazzar Ahoud , AlDehlawi Hebah
Published: October 2023

Background: Oral-pigmented lesions have raised aesthetic concerns, leading to multiple depigmentation techniques. This systematic review and network meta-analysis aimed to assess the efficacy of different treatments for oral hyperpigmentation. Methods: A computerized search was conducted on Science Direct, Medline via PubMed, Scopus, and Web of Science using the relevant keywords. English-language studies published between 2013 and 2023 that focused on patients with oral pigmented lesions subjected to different treatment modalities, such as laser or surgical intervention, were compared to determine their efficacy and safety profile. Data were analyzed using R software, applying frequentist models. Results: A total of 27 studies were included. In contrast to the CO2 laser, Er: YAG laser was linked to a higher risk of bleeding (RR = 2.73, p < 0.01), whereas the diode laser had the most favorable score in minimizing bleeding index (P-score = 0.86). In terms of lower risk and postoperative pain score (RR = 0.01, p < 0.01), the Er,Cr:YSGG laser had the most favorable result (P-score = 1.00). The Er: YAG laser demonstrated the highest probability of preventing recurrence (RR = 0.28, p < 0.01), followed by the diode laser (RR = 0.42, p < 0.01). Conclusions: The choice of treatment for oral pigmentation should be based on individual patient needs and the desired outcomes. The Er: YAG laser seems highly effective in preventing pigment recurrence, the diode laser emerges as a top contender in managing bleeding risks, and the Er,Cr:YSGG laser is particularly efficacious in managing postoperative pain.
Iron Chelation in Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms—Real-World Data from the German Noninterventional Study EXCALIBUR
Authors: Schulz Felicitas , Hauch Ulrich , Ketzler-Henkel Sandra , von der Heyde Eyck , Koenigsmann Michael , Lauseker Michael , Schulte Nora , Germing Ulrich
Published: October 2023

Myelodysplastic syndromes and myeloproliferative neoplasms both represent hematologic diseases associated with bone marrow failure often resulting in anemia. For those patients, transfusion of red blood cell (RBC) units is essential but results in iron overload (IOL) that may affect various organ functions. Therefore, iron chelation therapy plays a major role in anemic patients, not only because it reduces IOL, but also because it may improve hematopoietic function by increasing hemoglobin or diminishing the requirement for RBC transfusions. To assess the utility, efficacy, and safety of the different iron chelation medications approved in Germany, as well as to examine the effect of chelation on hematopoietic insufficiency, a prospective, multicenter, noninterventional study named EXCALIBUR was designed. In total, 502 patients from 106 German hospitals and medical practices were enrolled. A large proportion of patients switched from a deferasirox dispersible tablet to a deferasirox-film-coated tablet, mainly because of more convenient application, which was reflected in the treatment satisfaction questionnaire for medication scores. Iron chelation was effective in lowering serum ferritin levels, with the observed adverse drug reactions being in line with the known safety profile. Hematologic response occurred in a few patients, comparable to other studies that examined hematologic improvement in patients with MDS.
Nightmares and Sleep Disturbances in Children with PTSD: A Polysomnographic and Actigraphy Approach Evaluation
Authors: Rolling Julie , Rabot Juliette , Reynaud Eve , Kolb Oriane , Bourgin Patrice , Schroder Carmen M.
Published: October 2023

Rationale: Sleep disturbances (insomnia and nightmare symptoms) are the most sensitive and persistent symptoms of pediatric post-traumatic stress disorder (PTSD). Untreated, these sleep disturbances (SD) associated with PTSD are predictive of PTSD persistence and increased psychiatric complications. The aim of this study was to evaluate sleep and circadian rhythms in children with PTSD under both laboratory and ecological conditions in comparison with a control population and to test for the first time the hypothesis that SD and circadian rhythms are positively correlated with PTSD severity and its comorbidities. Method: This prospective pilot study evaluated PTSD, SD (insomnia, nightmares), and sleep-wake rhythms in 11 children with PTSD (aged 3–18), compared with the age and sex-matched control groups. Assessment of PTSD and subjective and objective measures of sleep and sleep-wake rhythms (questionnaires, 24-h in-laboratory video-polysomnography, 15-day at-home actigraphy recording) were performed between 1 and 6 months after the traumatic event. Results: Children with PTSD had higher sleep fragmentation (increased wake-after-sleep onset, increased number of sleep stage changes) compared to controls, with a change in sleep microarchitecture (micro-arousal index at 14.8 versus 8.2, p = 0.039). Sleep fragmentation parameters correlated with PTSD symptomatology, insomnia, and post-traumatic nightmare severity. The within-group comparison revealed a better sleep architecture in the controlled (sleep laboratory) than in the ecological condition (at home) (total sleep time 586 versus 464 min, p = 0.018). Conclusions: Sleep and rhythm disturbances are strongly associated with PTSD in children. The assessment of SD in children with PTSD should be carried out systematically and preferentially under ecological conditions, and management of SD should integrate the environment (environmental design, psycho-education for the children and their parents) more fully into therapy focused on sleep and trauma.
Incidence of Myelotoxicity and Other Adverse Effects Related to Thiopurine Starting in Patients with Inflammatory Bowel Disease: Retrospective Observational Study in a Third-Level Hospital
Authors: Grau Gerard , Brunet-Mas Eduard , Llovet Laura Patricia , Pedregal Patricia , Villoria Albert , Melcarne Luigi , Puy Anna , Garcia-Sague Belen , Frisancho Luis Enrique , Ramírez-Lázaro María José , Lario Sergio , Calvet Xavier
Published: October 2023

Background and objectives: Thiopurines are an effective treatment for the maintenance of remission in inflammatory bowel disease (IBD). They can present adverse effects (AEs), with myelotoxicity being the most relevant. This study aims to determine the incidence of AEs related to the starting of thiopurines in our centre. Methodology: Retrospective study. The AEs in patients that were started on thiopurines between January 2016 and June 2020 were registered, with a two-year follow-up. The mean and standard deviation were used to describe the quantitative variables, and percentages and confidence intervals were used for the qualitative variables. The statistical significance was set at a p-value < 0.05. Results: 98 patients were included, with 64 AEs detected in 48 patients (49%). Most of the AEs appeared in the first 6 months. The most relevant were: 21 neutropenia (21.4%), 19 hypertransaminasemia (19.4%), 13 digestive intolerances (13.2%), 6 acute pancreatitis (6.12%), 3 phototoxicity (3%), and 2 unknown origin fevers (2%). In 29 patients (29.4%) the treatment had to be suspended due to AEs. In 11 cases (11.2%), azathioprine (AZA) was switched to 6-mercaptopurine (6 MP) as 5 showed tolerance and 6 patients needed suspension due to AEs. Eight patients required hospital admission, but none of them needed intensive care unit admission. There were no fatal adverse effects. Conclusions: Thiopurines are a safe drug with few AEs, especially after the first months of treatment. These results suggest that periodic analytic follow-up may not be necessary after the initial period of treatment.
Expert Consensus on Clinical Decision Making in the Disease Trajectory of Oropharyngeal Dysphagia in Adults: An International Delphi Study
Authors: Speyer Renée , Balaguer Mathieu , Cugy Emmanuelle , Devoucoux Clémence , Morinière Sylvain , Soriano Gaëlle , Vérin Eric , Woisard Virginie
Published: October 2023

To date, no consensus exists on the complex clinical decision-making processes involved in oropharyngeal dysphagia, or swallowing disorders. This study aimed to develop an international consensus on a clinical decision tree for the disease trajectory of oropharyngeal dysphagia in adults, taking into account physiological impairments of swallowing, risk factors for the development of complications from oropharyngeal dysphagia, and prognostic factors for treatment outcomes. Using the Delphi technique, consensus was achieved among dysphagia experts across 31 countries, resulting in a total of 10 physiological impairments, 23 risk factors and 21 prognostic factors identified as relevant factors in the clinical decision-making process. Factors most contributing to the severity of oropharyngeal dysphagia were ‘Aspiration’, ‘Incomplete ejection or failure to eject aspirated materials from the airways’, ‘Weak or absent cough’, ‘Choking’ and ‘Sensory deficits in the oropharynx’. To connect the existing theoretical framework to clinical practice, future research will develop the current findings by corroborating the domains based on relevant factors for clinical decision making and those that contribute to the severity of oropharyngeal dysphagia.
The Expression of Activation Markers CD25 and CD69 Increases during Biologic Treatment of Psoriasis
Authors: Adamczyk Michał , Bartosińska Joanna , Raczkiewicz Dorota , Kowal Małgorzata , Surdacka Agata , Krasowska Danuta , Michalak-Stoma Anna , Krasowska Dorota
Published: October 2023

CD (cluster of differentiation) 69 and CD25 are considered early and late markers of the activation of lymphocytes, respectively. CD25 is a part of the IL-2 receptor and is present on the surface of immune and non-immune cells, with high amounts on activated lymphocytes and regulatory T cells. CD69 is expressed on various types of white blood cells, including newly activated lymphocytes, lymphocytes infiltrating tissues isolated from subjects with chronic auto-inflammatory diseases, several subtypes of memory T cells and regulatory T cells. Primarily, CD69 was considered to be an early marker of the activation of lymphocytes, but, right now, data derived from in vitro and in vivo studies have revealed the immunomodulatory role of this surface antigen. In 84 patients with psoriasis, of whom 28 were treated with different biologic drugs, as well as in 29 healthy control subjects, the expression of CD25 and CD69 on different subtypes of peripheral blood mononuclear cells (PBMCs) was studied with the use of flow cytometry. Significantly higher levels of CD3/CD69-, CD8/CD69- and CD19/CD69-positive PBMCs as well as within CD3+ cells were present in subjects suffering from psoriasis when compared to healthy controls. In patients with psoriasis who were treated with biologic drugs, the levels of CD3/CD69-, CD4/CD69- and CD19/CD69-positive PBMCs, and CD3/CD69 within CD3+ cells, CD4/CD69 within CD4+ cells, CD4/CD25 within CD4+ cells and CD19/CD69 within CD19+ cells were significantly higher than before therapy. Our results support a role for activation markers, especially CD69, in psoriasis. Further research is warranted to fully clarify their significance in this common dermatosis, especially during biologic treatment.
Comparative Analysis of Treatment Outcomes: Modified Ulnar Gutter Slab vs. Sugar Tong Slab for Distal Radioulnar Joint Instability Following Triangular Fibrocartilage Complex Repair
Authors: Tawonsawatruk Tulyapruek , Phoophiboon Pheeraphat , Kanchanathepsak Thepparat , Tuntiyatorn Panithan
Published: October 2023

The standard treatment for distal radioulnar joint (DRUJ) instability involves repairing the triangular fibrocartilage complex (TFCC) and immobilizing the joint with a sugar tong slab, but this can cause elbow stiffness. To address this, a modified ulnar gutter slab was designed to enhance elbow mobility during immobilization. A prospective randomized controlled trial was conducted on 23 DRUJ instability patients who underwent arthroscopic TFCC repair. Two post-operative splinting techniques were compared: the modified ulnar gutter slab and the sugar tong slab. The assessment included the Disabilities of Arm, Shoulder, and Hand (DASH) score; elbow, forearm, and wrist range of motion (ROM); post-operative DRUJ stability; and complications. DASH scores at 4 and 6 weeks were not significantly different. However, the modified ulnar gutter slab improved elbow extension range of motion at 4 weeks (extension lag: 20.0 vs. 6.5 in the sugar tong group) (p = 0.011). Post-operative DRUJ stability was comparable between the two groups. Notably, one patient in the sugar tong slab group experienced complex regional pain syndrome (CRPS). The modified ulnar gutter slab offers a post-operative alternative after TFCC repair. It effectively immobilizes forearm and wrist motion while enhancing elbow mobility, potentially reducing post-operative elbow stiffness.
Effect of Modified Triple-Layer Application on the Bond Strength of Different Dental Adhesive Systems to Dentin
Authors: Bourgi Rim , Kharouf Naji , Cuevas-Suárez Carlos Enrique , Lukomska-Szymańska Monika , Devoto Walter , Kassis Cynthia , Hasbini Omar , Mancino Davide , Haikel Youssef , Hardan Louis
Published: October 2023

The goal of this article was to assess the effect of modified triple-layer application (MTLA) in conjunction with the active bonding technique on the bond strength of four adhesive systems to dentinal substrate. The adhesives tested were Prime&Bond Universal (PBU), OptiBond Universal (OBU), OptiBond FL (OBFL), and Clearfil SE (CSE). The adhesives were applied according to the following strategies: single active application (A) and triple adhesive layer application including Active–Passive–Passive (APP); AAP; and AAA. The micro-tensile bond strength test was evaluated following 24 h or 6 months of storage. The composite–dentin interface morphology was investigated using scanning electron microscopy. The data were statistically analyzed with a significance level of α = 0.05. At 24 h of aging, all of the factors tested were not significant (p > 0.05) for CSE. For OBFL, OBU, and PBU, statistically higher values were observed for the A technique (p < 0.05). Plus, there were no significant variances between the APP, AAP, and AAA techniques (p > 0.05) for OBFL and PBU. However, for OBU, there were no significant differences between the A and AAA techniques (p > 0.05). After 6 months of aging, the A technique showed statistically higher values when compared to the other techniques (p < 0.01), except for OBFL, where the A and AAA techniques showed promising outcomes. When comparing the bond strength values of 24 h and 6 months, only for PBU, all of the techniques used resulted in bond strength stability over time (p > 0.05). Thicker adhesive layers were observed when MTLA was applied. Only the OBFL adhesive showed the formation of resin tags in all of the modalities tested. The bonding performances of the different application techniques used were material-dependent.
Theoretical Validation and Hardware Implementation of Dynamic Adaptive Scheduling for Heterogeneous Systems on Chip
Authors: Goksoy A. Alper , Hassan Sahil , Krishnakumar Anish , Marculescu Radu , Akoglu Ali , Ogras Umit Y.
Published: October 2023

Domain-specific systems on chip (DSSoCs) aim to narrow the gap between general-purpose processors and application-specific designs. CPU clusters enable programmability, whereas hardware accelerators tailored to the target domain minimize task execution times and power consumption. Traditional operating system (OS) schedulers can diminish the potential of DSSoCs, as their execution times can be orders of magnitude larger than the task execution time. To address this problem, we propose a dynamic adaptive scheduling (DAS) framework that combines the advantages of a fast, low-overhead scheduler and a sophisticated, high-performance scheduler with a larger overhead. We present a novel runtime classifier that chooses the better scheduler type as a function of the system workload, leading to improved system performance and energy-delay product (EDP). Experiments with five real-world streaming applications indicate that DAS consistently outperforms fast, low-overhead, and slow, sophisticated schedulers. DAS achieves a 1.29× speedup and a 45% lower EDP than the sophisticated scheduler under low data rates and a 1.28× speedup and a 37% lower EDP than the fast scheduler when the workload complexity increases. Furthermore, we demonstrate that the superior performance of the DAS framework also applies to hardware platforms, with up to a 48% and 52% reduction in the execution time and EDP, respectively.
Predicting Properties of Fused Filament Fabrication Parts through Sensors and Machine Learning
Authors: Liu Zijie , Mazzei Capote Gerardo A. , Grubis Evan , Pandey Apoorv , Blanco Campos Juan C. , Hegge Graydon R. , Osswald Tim A.
Published: October 2023

Fused filament fabrication (FFF), colloquially known as 3D-printing, has gradually expanded from the laboratory to the industrial and household realms due to its suitability for producing highly customized products with complex geometries. However, it is difficult to evaluate the mechanical performance of samples produced by this method of additive manufacturing (AM) due to the high number of combinations of printing parameters, which have been shown to significantly impact the final structural integrity of the part. This implies that using experimental data attained through destructive testing is not always viable. In this study, predictive models based on the rapid prediction of the required extrusion force and mechanical properties of printed parts are proposed, selecting a subset of the most representative printing parameters during the printing process as the domain of interest. Data obtained from the in-line sensor-equipped 3D printers were used to train several different predictive models. By comparing the coefficient of determination (R2) of the response surface method (RSM) and five different machine learning models, it is found that the support vector regressor (SVR) has the best performance in this data volume case. Ultimately, the ML resources developed in this work can potentially support the application of AM technology in the assessment of part structural integrity through simulation and can also be integrated into a control loop that can pause or even correct a failing print if the expected filament force-speed pairing is trailing outside a tolerance zone stemming from ML predictions.
Layout Optimization of a Tidal Current Turbine Array Based on Quantum Discrete Particle Swarm Algorithm
Authors: Wu Yanan , Wu He , Kang Hooi-Siang , Li He
Published: October 2023

This article focuses on the optimization of the layout of a tidal current turbine array (TCTA) using the Quantum Discrete Particle Swarm (QDPS) algorithm. The objective of the optimization is to balance the maximum energy output and minimum levelized cost of energy (LCOE). The optimization model proposed in this paper was constructed by combining a computational tidal model and the QDPS algorithm, which incorporate several advancements, including modeling of underwater terrain, obtaining tidal current field using high-fidelity ocean model, considering turbine properties, formulating partial influence of wakes on turbines, accounting for interactions between multiple wakes, modeling of safe operating distance, developing an LCOE model, and computing the sea space utilization area of a tidal farm. The proposed method was applied to optimize the layout of TCTA in a real waterway, which employed maximum tidal current fields during flooding and ebbing periods of spring tides as input for safety reasons. The results indicate that compared to a regular staggered layout, the total power generation improved by 19% and 16%, and the LCOE reduced by 12% and 15%, respectively, when the concluded optimized layout was utilized. Sea area decreased by 24% when LCOE was minimum. Overall, the proposed method has a better performance and can support the set selection as well as turbines placements of tidal current farms.
Construction Safety Risk Assessment and Early Warning of Nearshore Tunnel Based on BIM Technology
Authors: Wu Ping , Yang Linxi , Li Wangxin , Huang Jiamin , Xu Yidong
Published: October 2023

The challenging nature of nearshore tunnel construction environments introduces a multitude of potential hazards, consequently escalating the likelihood of incidents such as water influx. Existing construction safety risk management methodologies often depend on subjective experiences, leading to inconsistent reliability in assessment outcomes. The multifaceted nature of construction safety risk factors, their sources, and structures complicate the validation of these assessments, thus compromising their precision. Moreover, risk assessments generally occur pre-construction, leaving on-site personnel incapable of recommending pragmatic mitigation strategies based on real-time safety issues. To address these concerns, this paper introduces a construction safety risk assessment approach for nearshore tunnels based on multi-data fusion. In addressing the issue of temporal effectiveness when the conflict factor K in traditional Dempster–Shafer (DS) evidence theory nears infinity, the confidence Hellinger distance is incorporated for improvement. This is designed to accurately demonstrate the degree of conflict between two evidence chains. Subsequently, an integrated evaluation of construction safety risks for a specific nearshore tunnel in Ningbo is conducted through the calculation of similarity, support degree, and weight factors. Simultaneously, the Revit secondary development technology is utilized to visualize risk monitoring point warnings. The evaluation concludes that monitoring point K7+860 exhibits a level II risk, whereas other monitoring points maintain a normal status.
Marine Metrology and Oceanographic Measurements 2020
Authors: Rolle Francesca , Sega Michela
Published: October 2023

The measurement of oceanic parameters, and the consequent monitoring of their evolution in space and time, represent the basis for environmental information services that support a wide range of societal and commercial applications [...]
Speed Optimization in Bulk Carriers: A Weather-Sensitive Approach for Reducing Fuel Consumption
Authors: Shih You-Chen , Tzeng Yu-An , Cheng Chih-Wen , Huang Chien-Hua
Published: October 2023

The maritime industry faces the critical challenge of achieving net-zero greenhouse gas emissions by 2050, as mandated by the International Maritime Organization. This study introduces a novel speed optimization model, designed specifically for bulk carriers operating between two ports. Unlike conventional models that often assume static weather conditions, the proposed model incorporated variable weather conditions at different times of arrivals, as quantified by the Beaufort number (BN) and weather direction, for each leg of the voyage. Fuel consumption was estimated by applying regression to historical voyage data. This study employed a genetic algorithm (GA) to optimize vessel speed and thereby minimize fuel consumption. The model was tested by using different fuel consumption response curves relative to different BNs and weather directions. The results indicated that the proposed method could effectively reduce fuel consumption compared with the historical sailing mode by around 3%. The optimal speed recommendation indicated that the vessel should operate at a higher speed in circumstances associated with relatively low fuel consumption, such as lower BN and following sea conditions. Nonetheless, if it is possible to attain relatively low fuel consumption by adjusting the speed, the GA assesses the viability of this course of action. The study suggests that the predictive accuracy could be further enhanced by incorporating more granular, validated voyage data in future research.
Recognition and Tracking of an Underwater Pipeline from Stereo Images during AUV-Based Inspection
Authors: Bobkov Valery , Shupikova Antonina , Inzartsev Alexander
Published: October 2023

The inspection of condition of underwater pipelines (UPs) based on autonomous underwater vehicles (AUVs) requires high accuracy of positioning while the AUV is moving along to the object being examined. Currently, acoustic, magnetometric, and visual means are used to detect and track UPs with AUVs. Compared to other methods, visual navigation can provide higher accuracy for local maneuvering at short distances to the object. According to the authors of the present article, the potential of video information for these purposes is not yet fully utilized, and, therefore, the study focused on the more efficient use of stereo images taken with an AUV’s video camera. For this, a new method has been developed to address inspection challenges, which consists in the highlighting of visible boundaries and the calculation of the UP centerline using algorithms for combined processing of 2D and 3D video data. Three techniques for initial recognition of the direction of UP upon its detection were analyzed: on the basis of a stereo-pair of images using point features of the surface; using tangent planes to the UP in one of the stereo-pair; and using the UP median planes in both images of the stereo-pair. Approaches for determining the parameters of the relative positions of the AUV and the UP during the subsequent tracking are also considered. The technology proposed can be of practical use in the development of navigation systems to be applied for UP inspection without deploying additional expensive equipment, either separately or in combination with measurements from other sensors.
COVID-19 Pandemic and Indices Volatility: Evidence from GARCH Models
Authors: Mamilla Rajesh , Kathiravan Chinnadurai , Salamzadeh Aidin , Dana Léo-Paul , Elheddad Mohamed
Published: October 2023

This study examines the impact of volatility on the returns of nine National Stock Exchange (NSE) indices before, during, and after the COVID-19 pandemic. The study employed generalized autoregressive conditional heteroskedasticity (GARCH) modelling to analyse investor risk and the impact of volatility on returns. The study makes several contributions to the existing literature. First, it uses advanced volatility forecasting models, such as ARCH and GARCH, to improve volatility estimates and anticipate future volatility. Second, it enhances the analysis of index return volatility. The study found that the COVID-19 period outperformed the pre-COVID-19 and overall periods. Since the Nifty Realty Index is the most volatile, Nifty Bank, Metal, and Information Technology (IT) investors reaped greater returns during COVID-19 than before. The study provides a comprehensive review of the volatility and risk of nine NSE indices. Volatility forecasting techniques can help investors to understand index volatility and mitigate risk while navigating these dynamic indices.
Assessment and Mapping of Soil Salinity Using the EM38 and EM38MK2 Sensors: A Focus on the Modeling Approaches
Authors: Petsetidi Panagiota Antonia , Kargas George
Published: October 2023

Soil salinization and its detrimental agricultural, environmental, and socioeconomic impact over extended regions represent a major global concern that needs to be addressed. The sustainability of agricultural lands and the development of proper mitigation strategies require effective monitoring and mapping of the saline areas of the world. Therefore, robust modeling techniques and efficient sensors that assess and monitor the spatial and temporal variations in soil salinity within an area, promptly and accurately, are essential. The aim of this paper is to provide a comprehensive and up-to-date review of the modeling approaches for the assessment and mapping of saline soils using data collected by the EM38 and EM38MK2 (MK2) sensors at different scales. By examining the current and latest approaches and highlighting the most noteworthy considerations related to their accuracy and reliability, the intention of this review is to elucidate and underline the role of the EM38 and the MK2 type in the recent needs of detecting and interpreting soil salinity. Another aim is to assist researchers and users in selecting the optimal approach for future surveys and making well-informed decisions for the implementation of precise management practices. The study’s findings revealed that the integration of the EM38 and MK2 sensors with remote sensing data and advanced methods like machine learning and inversion is a promising approach to the accurate prediction and mapping of the spatiotemporal variations in soil salinity. Therefore, future research focused on validating and expanding such sophisticated modeling applications to regional and global scales should be increased.
An Overview of the Portuguese Electronic Jurisdictional Administrative Procedure
Authors: Oliveira António Mendes , Pedro Ricardo Lopes Dinis , Correia Pedro Miguel Alves Ribeiro , Lunardi Fabrício Castagna
Published: October 2023

In this paper, we seek to define the Portuguese Electronic Jurisdictional Administrative Procedure and characterize the scope and success of its implementation in terms of access to justice and court efficiency. It encompasses different perspectives on the judicial system and the electronic administrative procedure, reflecting the diversity of its authors, and combines a theoretical approach and discussion with statistics produced with official judicial data. Therefore, it introduces the issue and its background and discusses the models and principles of electronic judicial procedure and its representation in the Portuguese judicial procedure and law. It also presents the Portuguese exceptional and temporary regime for conducting judicial hearings in the context of the COVID-19 pandemic, discussing its merits and presenting the corresponding judicial statistics. The paper concludes that the advent of electronic judicial procedure, driven by technological advancements and aiming to achieve procedural effectiveness and efficiency, represents a paradigm shift and a change in the nature of the legal process, i.e., an ontological transformation in the theory of the process that requires a robust conceptual framework, to ensure consistent interpretation and application of procedural law and to guarantee respect for equality and legal certainty.
Assessing Drought Tolerance in a Large Number of Upland Cotton Plants (Gossypium hirsutum L.) under Different Irrigation Regimes at the Seedling Stage
Authors: Çelik Sadettin
Published: October 2023

The cotton plant is important since it provides raw materials for various industry branches. Even though cotton is generally drought-tolerant, it is affected negatively by long-term drought stress. The trial was conducted according to the applied experimental design as a completely randomized design (CRD) with three replications to determine a panel of 93 cotton genotypes’ genotypic responses against drought under controlled conditions in 2022. All genotypes were watered with 80 mL−1 of water (100% irrigation, field capacity) until three true leaves appeared, and then water stress was applied at a limited irrigation of 75% (60 mL−1), 50% (40 mL−1), and 25% (20 mL−1) of the field capacity. After the trial terminated at 52 days, the cv. G56, G44, G5, and G86 in RL; G1, G56, G44, G86, G51, and G88 in RFW; advanced line G5, followed by the cv. G56, advanced line G44, G75, and the cv. G90 in RDW; G44, followed by G86, the cv. G56, and elite lines G13 and G5 in NLRs were observed as drought-tolerant genotypes, respectively, while G35, G15, G26, G67, and G56 in SL; G15, G52, G60, G31, and G68 in SFW; G35, G52, G57, G41, and G60 in SDW show the highest drought tolerance means, respectively. In conclusion, the commercial varieties with high means in roots, namely G86, G56, G88, and G90, and the genotypes G67, G20, G60, and G57 showing tolerance in shoots, are suggested to be potential parent plants for developing cotton varieties resistant to drought. Using the cultivars found tolerant in the current study as parents in a drought-tolerant variety development marker-assisted selection (MAS) plant breeding program will increase the chance of success in reaching the target after genetic diversity analyses are performed. On the other hand, it is highly recommended to continue the plant breeding program with the G44, G30, G19, G1, G5, G75, G35, G15, G52, G29, and G76 genotypes, which show high tolerance in both root and shoot systems.
Novel tRNA Gene Rearrangements in the Mitochondrial Genomes of Poneroid Ants and Phylogenetic Implication of Paraponerinae (Hymenoptera: Formicidae)
Authors: Xiong Zijun , He Ding , Guang Xuanming , Li Qiye
Published: October 2023

Ants (Formicidae) are the most diverse eusocial insects in Hymenoptera, distributed across 17 extant subfamilies grouped into 3 major clades, the Formicoid, Leptanilloid, and Poneroid. While the mitogenomes of Formicoid ants have been well studied, there is a lack of published data on the mitogenomes of Poneroid ants, which requires further characterization. In this study, we first present three complete mitogenomes of Poneroid ants: Paraponera clavata, the only extant species from the subfamily Paraponerinae, and two species (Harpegnathos venator and Buniapone amblyops) from the Ponerinae subfamily. Notable novel gene rearrangements were observed in the new mitogenomes, located in the gene blocks CR-trnM-trnI-trnQ-ND2, COX1-trnK-trnD-ATP8, and ND3-trnA-trnR-trnN-trnS1-trnE-trnF-ND5. We reported the duplication of tRNA genes for the first time in Formicidae. An extra trnQ gene was identified in H. venator. These gene rearrangements could be explained by the tandem duplication/random loss (TDRL) model and the slipped-strand mispairing model. Additionally, one large duplicated region containing tandem repeats was identified in the control region of P. clavata. Phylogenetic analyses based on protein-coding genes and rRNA genes via maximum likelihood and Bayes methods supported the monophyly of the Poneroid clade and the sister group relationship between the subfamilies Paraponerinae and Amblyoponinae. However, caution is advised in interpreting the positions of Paraponerinae due to the potential artifact of long-branch attraction.
The Genetic Code Assembles via Division and Fusion, Basic Cellular Events
Authors: Yarus Michael
Published: October 2023

Standard Genetic Code (SGC) evolution is quantitatively modeled in up to 2000 independent coding ‘environments’. Environments host multiple codes that may fuse or divide, with division yielding identical descendants. Code division may be selected—sophisticated gene products could be required for an orderly separation that preserves the coding. Several unforeseen results emerge: more rapid evolution requires unselective code division rather than its selective form. Combining selective and unselective code division, with/without code fusion, with/without independent environmental coding tables, and with/without wobble defines 25 = 32 possible pathways for SGC evolution. These 32 possible histories are compared, specifically, for evolutionary speed and code accuracy. Pathways differ greatly, for example, by ≈300-fold in time to evolve SGC-like codes. Eight of thirty-two pathways employing code division evolve quickly. Four of these eight that combine fusion and division also unite speed and accuracy. The two most precise, swiftest paths; thus the most likely routes to the SGC are similar, differing only in fusion with independent environmental codes. Code division instead of fusion with unrelated codes implies that exterior codes can be dispensable. Instead, a single ancestral code that divides and fuses can initiate fully encoded peptide biosynthesis. Division and fusion create a ‘crescendo of competent coding’, facilitating the search for the SGC and also assisting the advent of otherwise uniformly disfavored wobble coding. Code fusion can unite multiple codon assignment mechanisms. However, via code division and fusion, an SGC can emerge from a single primary origin via familiar cellular events.
Bilateral Carotid Artery Molecular Calcification Assessed by [18F] Fluoride PET/CT: Correlation with Cardiovascular and Thromboembolic Risk Factors
Authors: Patil Shiv , Teichner Eric M. , Subtirelu Robert C. , Parikh Chitra , Al-Daoud Omar , Ismoilov Miraziz , Werner Thomas , Høilund-Carlsen Poul Flemming , Alavi Abass
Published: October 2023

Atherosclerosis, a leading cause of mortality and morbidity worldwide, involves inflammatory processes that result in plaque formation and calcification. The early detection of the molecular changes underlying these processes is crucial for effective disease management. This study utilized positron emission tomography/computed tomography (PET/CT) with [18F] sodium fluoride (NaF) as a tracer to visualize active calcification and inflammation at the molecular level. Our aim was to investigate the association between cardiovascular risk factors and [18F] NaF uptake in the left and right common carotid arteries (LCC and RCC). A cohort of 102 subjects, comprising both at-risk individuals and healthy controls, underwent [18F] NaF PET/CT imaging. The results revealed significant correlations between [18F] NaF uptake and cardiovascular risk factors such as age (β = 0.005, 95% CI 0.003–0.008, p < 0.01 in LCC and β = 0.006, 95% CI 0.004–0.009, p < 0.01 in RCC), male gender (β = −0.08, 95% CI −0.173–−0.002, p = 0.04 in LCC and β = −0.13, 95% CI −0.21–−0.06, p < 0.01 in RCC), BMI (β = 0.02, 95% CI 0.01–0.03, p < 0.01 in LCC and β = 0.02, 95% CI 0.01–0.03, p < 0.01 in RCC), fibrinogen (β = 0.006, 95% CI 0.0009–0.01, p = 0.02 in LCC and β = 0.005, 95% CI 0.001–0.01, p = 0.01), HDL cholesterol (β = 0.13, 95% CI 0.04–0.21, p < 0.01 in RCC only), and CRP (β = −0.01, 95% CI −0.02–0.001, p = 0.03 in RCC only). Subjects at risk showed a higher [18F] NaF uptake compared to healthy controls (one-way ANOVA; p = 0.02 in LCC and p = 0.04 in RCC), and uptake increased with estimated cardiovascular risk (one-way ANOVA, p < 0.01 in LCC only). These findings underscore the potential of [18F] NaF PET/CT as a sensitive tool for the early detection of atherosclerotic plaque, assessment of cardiovascular risk, and monitoring of disease progression. Further research is needed to validate the technique’s predictive value and its potential impact on clinical outcomes.
Editorial on the Special Issue “The New Frontier of Venous Thromboembolism”
Authors: Di Micco Pierpaolo , Imbalzano Egidio , Camporese Giuseppe
Published: October 2023

In recent years, great efforts have been made to improve decision making in caring for patients of venous thromboembolism (VTE) [...]
Which Coronary Artery Should Be Preferred for Starting the Coronary Spasm Provocation Test?
Authors: Teragawa Hiroki , Uchimura Yuko , Oshita Chikage , Hashimoto Yu , Nomura Shuichi
Published: October 2023

Background: The spasm provocation test (SPT) is a critical test for diagnosing vasospastic angina (VSA). However, the choice of vessel to be preferred for initiating the SPT—the right coronary artery (RCA) or the left coronary artery (LCA)—is unclear. This study aimed to assess SPT results including SPT-related complications while initiating the SPT in the RCA and LCA. Methods: We enrolled 225 patients who underwent coronary angiography and SPTs. The SPT was first performed in the RCA in 133 patients (RCA group) and the LCA in 92 patients (LCA group). We defined VSA as >90% narrowing of the coronary artery during the SPT, accompanied by chest pain and/or ST–T changes on the electrocardiogram. When coronary spasm occurs in two or more major coronary arteries, it is referred to as a multivessel spasm (MVS). SPT-related complications comprised atrial fibrillation, ventricular fibrillation, and unstable hemodynamics following catecholamine use. Analyses using propensity score matching (PSM) were performed in 120 patients. Results: No significant differences in the frequencies of VSA and complications were observed between the two groups (RCA: 79% and 19%, respectively; LCA: 85% and 22%, respectively). In both groups, spasms were most frequently provoked in the left anterior descending coronary artery (both p < 0.001) whereas spasms in the left circumflex coronary artery (LCX) were higher in the LCA group than in the RCA group (p = 0.015). Furthermore, no significant difference in the frequency of MVS was observed between both groups (RCA: 50%, LCA: 62%; p = 0.122). After PSM, no significant difference in the frequencies of VSA and complications were observed between the two groups (RCA: 82% and 15%, respectively; LCA: 88% and 18%, respectively). The frequencies of LCX spasms (RCA: 8%, LCA: 23%; p = 0.022) and MVS (RCA: 40%, LCA: 62%; p = 0.020) were higher in the LCA group than in the RCA group. Conclusions: Although the diagnostic rate of VSA and frequency of SPT-related complications were similar in the two groups, the frequency of MVS was higher in the LCA group than in the RCA group because of the increase in the number of LCX spasms. A routine SPT may be started from the LCA.
Restoration of Hip Geometry after Femoral Neck Fracture: A Comparison of the Femoral Neck System (FNS) and the Dynamic Hip Screw (DHS)
Authors: Niemann Marcel , Maleitzke Tazio , Jahn Markus , Salmoukas Katharina , Braun Karl F. , Graef Frank , Stöckle Ulrich , Meller Sebastian
Published: October 2023

Background: The femoral neck system (FNS) was introduced as a minimally invasive fixation device for managing femoral neck fractures. Objective: To compare radiographic, clinical, and patient-reported outcome measures (PROMs) of femoral neck fracture patients following FNS compared to dynamic hip screw (DHS) implantation combined with an anti-rotational screw. Methods: Patients who underwent closed reduction and internal fixation of a femoral neck fracture between 2020 and 2022 were retrospectively included. We measured leg length, femoral offset, and centrum–collum–diaphyseal (CCD) angle in plain radiographs. Scar length, Harris Hip Score, short-form health survey 36-item score (SF-36), and Numeric Rating Scale (NRS) were assessed during follow-up visits. Results: We included 43 patients (22 females) with a median age of 66 (IQR 57, 75). In both groups, leg length differences between the injured and the contralateral side increased, and femoral offset and CCD angle differences were maintained over time. FNS patients had shorter scars and reported fewer emotional problems and more energy. There were no differences between groups regarding the remaining SF-36 sub-scores, Harris Hip Score, and NRS. Conclusions: The FNS allows for a comparable leg length, femoral offset, and CCD angle reconstruction while achieving similarly high functional and global health scores to the DHS.