bluuebunny/crossref_metadata_2025 huggingface dataset:
KRAS/NRAS Mutational Analysis and Clinicopathologic Correlation of Colorectal Carcinoma: A Single Institute Experience From Turkey
Authors: A. Mine Onenerk , Hanif Gulnihal Ozdemir , Selvinaz Ozkara , Aker Vardar Fugen Aker , Oven Basak Ustaalioglu
Published: July 2024

Background: Colorectal carcinoma (CRC) is the second most frequent cause of cancer-related death for both sexes. Clinical and pathological correlates of Kirsten rat sarcoma viral oncogene/neuroblastoma ras viral oncogene (KRAS/NRAS) mutant tumors are important for therapy response, especially in metastatic CRCs. The aim of this study is to determine the frequency of KRAS/NRAS mutations and investigate the clinicopathologic characteristics of KRAS/NRAS mutant and rat sarcoma (RAS)-wild type CRCs. Methods: Pathology archives were searched for CRCs between 2014 and 2015, retrospectively. We reevaluated tumor slides for Crohn-like infiltrate, tumor infiltrating lymphocytes, tumor budding, presence of mucinous component, and signet-ring cell morphology. Tumor grade, depth of invasion, lymph node metastases, distant metastases, lymphovascular and perineural invasion, polyp type, and DNA mismatch repair status were derived from their pathology reports. Formalin-fixed, paraffin-embedded tissues were examined for KRAS/NRAS mutation status. Mutation status and their clinicopathologic correlates were evaluated. Results: KRAS and NRAS mutations were detected in 43.6% and 10% of the CRCs, respectively. KRAS mutations were associated with multiple organ metastasis and CRCs with solid growth pattern did not harbor RAS mutations. Well differentiated CRCs were more common in NRAS mutant and RAS-wild type CRCs in comparison to RAS mutant tumors. NRAS mutant CRCs were more frequent in the left colon and rectum. Conclusion: In this study, we identified that KRAS mutations were associated with multiple organ metastasis and CRCs with solid growth pattern did not harbor RAS mutations. Also, NRAS mutant tumors were more common in the left colon and rectum concordant with the previous studies.

Keywords: colorectal carcinoma, metastatic colorectal carcinoma, KRAS, NRAS
Gen Füzyonlar ve Tiroid Kanseri
Authors: ÇELİKEL Burcu , AKSAKAL Nihat , ÖNDER Semen , YEGEN Gülçin , ZEYBEK Ümit
Published: July 2024

Tiroid kanseri, endokrin maligniteler arasında en yaygın
görülenidir. Tiroid kanserlerine özellikle tiroid nodülü
tespiti ve örneklemenin daha sıklıkla uygulandığı gelişmiş
ve gelişmekte olan ülkelerde daha çok rastlanmaktadır.
Çoğu tiroid kanseri yavaş bir klinik tablosu sergilemesine
rağmen, artış gösteren insidansı tümör hücrelerinde bulunan
onkojenik değişikliklerin araştırılmasını ve onları
hedefleyen tedavileri de beraberinde getirmiştir. Birçok
kanserde driver veya passenger mutasyonları olarak bilinen
füzyon genleri, iki ya da daha fazla genin parçalarının
birleşmesine yol açan kimerik genlerdir. Kromozomal
yeniden düzenlemelerin veya anormal transkripsiyonun
sonucu olarak oluşabilirler. Füzyon genleri, tiroid kanseri
ve çeşitli kanser türlerinin tanısı ve hedef ilaç belirlenebilmesi
için yararlı biyobelirteçler olarak kabul edilmiş ve
tespit edilen değişiklikler klinikte hastaların hedefli tedavileri
için uygulamaya alınmıştır. Gen füzyonu pozitif olan
hastaya uygun tirozin kinaz inhibitörü (TKI) ilaç tedavisi
başlanabilmektedir. Günümüzde çok sayıda TKI ajan küçük
hücre dışı akciğer kanseri, tiroid kanseri ve melanoma
gibi çeşitli kanserlerde kullanılmaktadır. Hastalar böylelikle
hedefli tedaviden yararlanabilmekte ve progresyonsuz
sağkalım ve kaliteli yaşam süreci elde edilebilmektedir.
Bu derlemede tiroid kanserinde tespit edilen gen füzyonlarının
açıklanması ve tirozin kinaz hedefli tedavilerin
öneminin vurgulanması hedeflenmiştir.
The Effect Of Casgot Property On The Biological Properties Of Soil In Which Cucumbers Are Planted
Authors: Ryan Agfandri Dwi , Walida Hilwa , Elizabeth Mustamu Novilda , Ainy Dalimunthe Badrul
Published: July 2024

Soil biological properties are various aspects related to the life of microorganisms and macroorganisms in the soil and biological activities. This study aims to understand how soil organisms and their biological activities contribute to soil fertility and plant health. This study used a purposive sampling method and was analyzed using descriptive analysis. Soil biological properties, including the total number of bacteria and fungi, were observed to assess the effect of Black Soldier Fly larvae (kasgot) fertilizer application. The results showed that treatment variations had a significant effect on the population of fungi and bacteria in the rhizosphere. The highest value of the fungal population was recorded in the M1 treatment without the first treatment, while the lowest value was in the M1 treatment with the first treatment, indicating that the type and frequency of treatment can drastically affect fungal growth. For the bacterial population, the M3 treatment in the first application showed the highest effectiveness, while the M2 treatment in the second application showed the lowest results, highlighting the importance of the dose and application stage in increasing the bacterial population. Overall, this study emphasizes the importance of selecting the right treatment to optimize the soil microbial population in agricultural practices.
Perancangan Model Bisnis dengan Menggunakan Business Model Canvas yang Berfokus pada Blok Marketing pada Umkm XYZ
Authors: Haynes Erin , Chumaidiyah Endang , Almaududi Pulungan Muhammad
Published: July 2024

XYZ merupakan sebuah usaha mikro kecil dan menengah (UMKM) yang menjual berbagai jenis kebutuhan di e-commerce Tokopedia dan Shopee. Akan tetapi, penjualan di e-commerce Tokopedia mengalami penurunan sejak bulan Oktober tahun 2022. Oleh karena itu, dilakukanlah perancangan model bisnis usulan demi meningkatkan pendapatan bisnis XYZ. Penelitian ini menggunakan metode kualitatif untuk merancang model bisnis XYZ menggunakan Business Model Canvas. Penelitian ini diawali dengan memetakan Business Model Canvas eksisting dari XYZ, lalu analisis profil pelanggan, dan kemudian dilakukan analisis SWOT. Setelah itu, dilakukan perancangan model bisnis yang baru dari XYZ. Dari hasil perancangan model bisnis usulan yang berfokus pada blok marketing yaitu pada blok customer relation, customer segment, dan channel dari XYZ. Maka, dibuatlah perancangan platform pemasaran baru melalui Tik-Tok guna meningkatkan pendapatan XYZ
Harga Diri Dan Body Image Pada Mahasiswa/i Etnis Papua Di Universitas Kristen Satya Wacana
Authors: Angelica Saragih Chelsea
Published: July 2024

Body image merupakan gambaran penampilan fisik mahasiswa/i etnis Papua yang mengevaluasi diri dengan memunculkan persepsi berupa penilaian positif dan negatif. Harga diri merupakan penilaian yang dilakukan oleh mahasiswa etnis papua terhadap dirinya sendiri baik secara positif maupun negatif. Faktor lain yang memengaruhi body image selain harga diri yaitu lingkungan sekitar dan dukungan sosial. Penelitian ini menggunakan pendekatan kuantitatif dengan desain korelasional yang bertujuan untuk mengetahui hubungan antara harga diri dan body image pada mahasiswa/i etnis Papua di Universitas Kristen Satya Wacana. Partisipan dalam penelitian sebanyak 205 mahasiswa/i etnis Papua. Alat ukur yang digunakan adalah adalah Rosenberg Self-Esteem dan MBSRQ-AS (Multidimensional Body-Self Relations Questionaire-Appearance Scales). Berdasarkan jumlah perhitungan dengan menggunakan program SPSS versi 22 yang menghasilkan uji reliabilitas pada skala harga diri sebesar 0,854 dan reliabilitas skala body image sebesar 0,958 yang artinya kedua skala tersebut memenuhi syarat reliabilitas. Analisis data menggunakan korelasi Spearman’s Rho. Berdasarkan hasil penelitian yang telah dilakukan, diperoleh hasil yang menunjukkan nilai r = 0,637 dan nilai signifikansi sebesar 0,000 (p<0,05), yang berarti terdapat hubungan positif yang signifikan antara harga diri dengan body image pada mahasiswa/i etnis papua Universitas Kristen Satya Wacana. Artinya, semakin tinggi harga diri maka semakin positif body image. Sebaliknya, semakin rendah harga diri maka semakin negatif body image.
Pengaruh Media Educandy Terhadap Motivasi Belajar Dan Hasil Belajar Siswa
Authors: Rahmanti Nita , Halimah Leli , Sutini Ai
Published: July 2024

Pentingnya anak belajar IPS karena merupakan suatu ilmu yang berhubungan dengan lingkungan dan masyarakat social, agar siswa menjadi warga negara yang demokratis, bertanggung jawab serta cinta damai, untuk mengoptimalkan pembelajaran IPS diperlukan adanya motivasi yang kuat dari siswa  yang menjadi dorongan agar terjadinya interaksi yang dapat memungkinkan untuk siswa memperoleh hasil belajar yang tinggi. Tujuan dari penelitian ini adalah mengetahui apakah terdapat pengaruh yang signifikan dengan penggunaan aplikasi educandy terhadap motivasi dan hasil belajar IPS siswa. Alasan pentingnya aplikasi Educandy dalam upaya meningkatkan motivasi dan hasil belajar IPS karena Educandy Salah satu permainan yang merupakan hasil perkembangan dari teknologi digital. Metode penelitian ini menggunakan pendekatan eksperimen semu (Quasi Experiment Design). dengan menggunakan instrumen pengumpulan data berupa angket motivasi, angket hasil belajar untuk penguatan, wawancara, penggunaan media aplikasi educandy serta observasi. Hasil penelitian yang didapat menunjukan bahwa motivasi belajar ketika menggunakan media pembelajaran Educandy sangatlah termotivasi dengan adanya suatu rangsangan untuk peserta didik ketika belajar,begitu pula dengan hasil belajar yang menunjukan bahwa hasil belajar merupakan suatu hasil/nilai yang diperoleh oleh peserta didik ketika sudah mengetahui ilmu yang didapat baik dari aspek psikomotor, kognitif maupun afektif, Hasil penelitian juga membuktikan bahwa pengaruh aplikasi Educandy terhadap motivasi belajar dan hasil belajar sebesar 0,04% selebihnya ditentukan oleh variabel lain.
The Effect of Net Interest Margin (NIM), Operating Expenses, Operating Income (BOPO), Loan to Deposit Ratio (LDR), on Return on Assets (ROA) at PT Bank Mayapada Internasional Tbk for the Period of 2014-2023
Authors: Karunia Antika E Landitha , Permata Rahmi Palupi , Sudaryo Yoyo , Nur Sumawidjaja Riyandi , Febriyanti Diah
Published: July 2024

Profitability is a ratio to assess the company's ability to seek profit. This ratio also provides a measure of the level of effectiveness of a company's management. Profitability at PT Bank Mayapada Internasioanl Tbk in 2014-2023 fluctuated every year and tended to decline at the end of the research year. This study aims to determine the effect of Net Interest Margin (NIM), Operating Costs of Operating Income (BOPO), Loan to Deposit Ratio (LDR) on Return On Assets (ROA) for the 2014- 2023 period. This study uses a quantitative method with a descriptive verification approach. The data source used is secondary data with documentation data collection inthe form of annual financial reports and purposive sampling technique. The data analysis technique used is descriptive analysis, regression analysis, correlation analysis, coefficient of determination analysis, and hypothesis testing either partially or simultaneously with the help of the SPSS 25 program. The research results show that the average ROA is 0.919%, categorized as healthy. However, ROA in the last 2 years of the 2022-2023 research period has decreased drastically with the lowest value being 0.04% and is below Bank Indonesia's provisions for the healthy ROA category, namely 1.5%. The average NIM is 3.13% which is categorized as healthy, but in the year of research, namely 2020, it dropped drastically with a minimum value of 0.47%, even far from the minimum limit of 6% according to Bank Indonesia regulations for the healthy NIM category. The average BOPO is 91.79 which is categorized as healthy, but BOPO at the end of the research period in 2024 rose to the highest value, namely 99.40% and is above Bank Indonesia's provisions for the healthy BOPO category, namely a maximum of 85%. The average LDR is 85.10% which is categorized as however the LDR in the 3 years at the end of the research period in 2021 has decreased drastically with the lowest value being 71% and the highest value in 2019 even approaching the maximum and minimum limits, namely 80%-110% accordingly. Bank Indonesia provisions for the healthy LDR category. Partially NIM has no effect on ROA with a contribution of1.80%. BOPO has no effect on ROA with a contribution of 99.40%. LDR has a significant effect on ROA with a contribution of 88.59%. Together (simultaneously) NIM, BOPO, LDR have a significant influence on ROA at PT Bank Mayapada Internasional Tbk for the 2014-2023 period.
Peranan Soil Tilth Terhadap Produktivitas Bawang Merah
Authors: Dwi Wahjunie Enni , Malahayati Yusuf Sri , Syahputri Hairani Raissa
Published: July 2024

Bawang merah merupakan salah satu komoditas pangan yang penting, sehingga  lahan produksinya perlu dipertahankan. Apabila produktivitas lahannya menurun, sangat potensi  beralih fungsi menjadi lahan penggunaan lain. Sentra produksi bawang merah terbesar di Indonesia berada di Kabupaten Brebes, yang dikembangkan di berbagai jenis tanah dengan karakter berbeda.  Perbedaan jenis tanah tersebut telah menunjukkan perbedaan produksinya.  Sebagai tanaman  umbi, bawang merah memerlukan media tanam yang baik (soil tilth), antara lain konsistensi dan kemampuan mengembang mengkerut tanah. Oleh karena itu, penelitian ini ingin mengkaji peranan soil tilth dan kemampuan mengembang mengkerut tanah terhadap produktivitas bawang merah.  Penelitian dilakukan melalui tahapan survei lokasi pengembangan bawang merah di Kabupaten Brebes, pengumpulkan data produksinya di berbagai jenis tanah sentra produksi, analisis sifat-sifat tanah terutama konsistensi dan COLE (coeficient of linier extensibility), dan  analisis keterkaitan sifat tanah terhadap produksi bawang merah.  Hasil penelitian menunjukkan bahwa budidaya bawang merah di Kabupaten Brebes berada di tanah Kambisol Eutrik, Gleisol Eutrik, dan Mediteran Haplik. Kambisol Eutrik memiliki produktivitas bawang merah tertinggi diikuti oleh Mediteran Haplik dan Gleisol Eutrik. Konsistensi dan nilai COLE tanah berbeda antar jenis tanah. Indeks plastisitas, jangka olah, dan nilai COLE dipengaruhi oleh kadar klei dan bahan organik tanah. Semakin tinggi kadar klei dan makin rendah kadar bahan organik, sifat olah tanah makin buruk dan produksi makin rendah.
Linfoma anaplásico de grandes células relacionado ao implante mamário: uma revisão da literatura
Authors: Lucas Matheus Galante Tiopisto Mendonça , Guerra Larissa Pereira , Mendanha Neto Luana , Franco João Pedro Duarte , Duarte Roberta
Published: July 2024

Introdução: O linfoma anaplásico de grandes células associado ao implante mamário (BIA-ALCL) é um raro linfoma de células T frequentemente relacionado a implantes texturizados. Reconhecido pela OMS em 2016, esse linfoma geralmente se manifesta como seroma peri-implante tardio ou massa. Materiais, sujeitos e métodos: Revisões sistemáticas e análises de casos foram conduzidas para identificar a incidência, mecanismos patogênicos, diagnóstico e tratamento de BIA-ALCL. Estudos incluíram revisões da literatura, análise de banco de dados clínicos e diretrizes de manejo. Resultados e discussão: A incidência de BIA-ALCL é maior em pacientes com implantes texturizados, apresentando sintomas entre 7-10 anos após a implantação. O diagnóstico é feito por citologia e imuno-histoquímica (CD30) do líquido seroso ou tecido capsular. A inflamação crônica e a resposta imune ao implante texturizado são mecanismos propostos. Considerações finais: Embora BIA-ALCL seja raro, sua incidência está aumentando, especialmente em países com alta prevalência de aumento mamário. Protocolos de detecção precoce e medidas preventivas são cruciais para melhorar os desfechos dos pacientes. Estudos futuros são necessários para entender melhor os fatores de risco e otimizar as diretrizes de tratamento.
Mortalidade por melanoma maligno da pele em idosos do Brasil: uma revisão da literatura
Authors: Dias Valentina Morais , Caixeta Laura Vitória Viana , Oliveira Bruna Onesco de , Trein Sofia
Published: July 2024

O melanoma é a neoplasia maligna cutânea que se desenvolve nos melanócitos, células produtoras de pigmento. Sua incidência tem aumentado em todo o mundo nos últimos anos, sendo motivo de grande preocupação para as entidades médicas devido à sua alta letalidade. O presente artigo visa avaliar, através de uma revisão de literatura, a mortalidade por melanoma maligno cutâneo na população idosa brasileira. Para a elaboração deste artigo, foram consultados artigos científicos publicados e referenciados no PUBMED e no SciELO Brasil. A revisão evidencia que a idade avançada relaciona-se diretamente com o aumento da mortalidade por melanoma (Brown et al., 2020). Ademais, percebe-se essa relação com o sexo masculino, que, independentemente da idade avaliada, apresentou maior incidência e taxas de mortalidade por esta neoplasia (Nader et al., 2020; Santos e Souza, 2019; Vasquez et al., 2015). Devido à sua situação geográfica, o Brasil constitui uma região com alta incidência de raios solares durante todo o ano. Isto se relaciona à crescente incidência da doença e, associado ao aumento da mortalidade por melanoma cutâneo, evidencia um problema de saúde pública. Torna-se imprescindível o incentivo à prevenção do câncer de pele não só em idosos, mas principalmente entre jovens, já que este grupo, apesar de menor incidência da afecção, apresenta maiores taxas de exposição solar, o que incrementa o acúmulo quantitativo de radiação solar ao longo da vida.
O papel das citocinas no colesteatoma adquirido da orelha média: revisão da literatura
Authors: Belli Júlia , Rocha Gabrielle Justiniana Fontes , Diniz Pedro Vitor Machado Borges , Pereira Letícia Corrêa
Published: July 2024

Introdução: O colesteatoma adquirido da orelha média é definido como uma lesão benigna de caráter inflamatório e crônico, caracterizado pelo acúmulo de células do epitélio escamoso queratinizado no ouvido médio. Objetivo: Descrever, por meio de uma revisão da literatura, como as citocinas atuam no desenvolvimento do colesteatoma adquirido da orelha média. Materiais/sujeitos e métodos: A fundamentação teórica baseou-se na consulta de artigos científicos e de revisão publicados nas bases de dados Medline/PubMed e SciELO entre 1995 e 2023, em português e inglês. Resultados e discussão: A heterogeneidade dos métodos usados nos artigos revisados pode afetar a comparação dos resultados. A falta de padronização dos critérios de inclusão e exclusão dos estudos pode criar vieses. Para futuras pesquisas, os estudos longitudinais devem ter amostras maiores e métodos padronizados para validar esses achados. Considerações finais: Nesta revisão, foi observada a citação de diversas citocinas atuando neste processo de evolução da doença, porém, pela própria característica das citocinas, não há um consenso em qual citocina é responsável pela doença, já que muitas estão presentes neste processo. As citocinas agem em sinergismo além de atuarem em um mesmo sítio.
Epidermólise bolhosa hereditária: uma revisão da literatura
Authors: Ribeiro Millena de Freitas , Torres Amanda , Nery Bernardo Machado Veloso , Silva Milena Barrera , Dias Luana Rossato
Published: July 2024

Introdução: A Epidermólise Bolhosa Hereditária (EBH) é uma alteração genética rara que se caracteriza pela fragilidade da pele formando bolhas em resposta a mínimos traumas (BOEIRA et al., 2013). Divide-se em quatro principais tipos - EB simples, EB juncional, EB distrófica e síndrome de Kindler e cada uma dessas variantes está associada a mutações específicas que determinam a severidade e os padrões clínicos da patologia (Bruckner-Tuderman e Has, 2018). Devido a essa grande variação clínica e genética, a EBH torna-se uma patologia complexa e relevante e exige uma abordagem multidisciplinar para seu diagnóstico e tratamento (Fine et al., 2021). O presente artigo busca através de uma revisão sistemática e atual da literatura delinear a etiopatogenia, o diagnóstico e a terapêutica da EBH. Materiais, sujeitos e métodos: Para a elaboração deste artigo de revisão foram consultados artigos científicos e referenciados artigos de revisão publicados e na Medline/PubMED, SciELO e Cochrane e Scholar Google entre 2013 e 2024. A seleção dos artigos foi baseada na relevância para a temática da EBH, bem como na qualidade metodológica dos estudos revisados. Resultados e discussão: Evidências revelam que as manifestações clínicas da EBH variam amplamente, incluindo desde bolhas e feridas cutâneas até complicações sistêmicas como cicatrizes, contraturas articulares e risco aumentado de carcinoma espinocelular (Fine et al., 2021). Desse modo, existem inúmeras recomendações de cuidado para pacientes com EBH que abarcam desde estratégias para a prevenção de lesões como o manejo das feridas crônicas. Has et al. (2020) e Kiritsi e Nyström (2021) fornecem diretrizes para cuidados com a pele, incluindo o uso de curativos especiais que minimizam o trauma cutâneo e o manejo adequado de bolhas e feridas. Considerações finais: A epidermólise bolhosa permanece sendo uma condição desafiadora devido à sua heterogeneidade genética e à severidade das suas manifestações clínicas. Atualmente, avanços significativos em terapias gênicas e tratamentos com células-tronco demonstram um importante potencial no manejo da EBH possibilitando assim intervenções personalizadas e terapias eficazes capazes de melhorar a qualidade de vida dos pacientes (Chung e Uitto, 2020; Has et al., 2020).
Prurigo agudo bolhoso hemorrágico: uma revisão da literatura
Authors: Amendola Thaís Sales , Nobre Ana Laura Nobre e , Oliveira Maria Eduarda Gibbon , Pereira Maitê Perini Mameri , Alves Lívia Gabriela Campos
Published: July 2024

Introdução: Os acidentes causados por picadas ou mordeduras de insetos são subdiagnosticados, uma vez que grande parte dos pacientes não relatam o ocorrido. Porém, mesmo com esse subdiagnóstico, sabe- se que esses episódios são muito comuns. Existe um amplo espectro de apresentação das lesões cutâneas após o incidente com os insetos, podendo variar desde lesões menos complexas até mesmo bolhas hemorrágicas, especialmente após a picadas de tabanídeos. Este artigo objetiva realizar uma revisão de literatura sobre as particularidades verificadas na saliva dos insetos hematófagos e a importância do conhecimento acerca do prurigo agudo bolhoso hemorrágico para diagnóstico diferencial com outras lesões bolhosas. Materiais, sujeitos e métodos: Para a confecção do presente artigo foi consultado artigo de revisão, artigo científico e relatos de casos publicados e referenciados na plataforma SciELO, Site da Sociedade Brasileira de Pediatria e Anais Brasileiros de Dermatologia entre 2003 e 2020. Além disso, foi consultado um livro de Dermatologia, com data de publicação de 2022. Resultados e discussão: Ao se analisar as propriedades da saliva das mutucas, da família Tabanidae, nota-se, entre outras, suas características anticoagulantes, vasodilatadoras e quimiotáticas que juntas garantem a vitória do hematofagismo (SILVA, 2009) Considerações finais: Assim, em pacientes predispostos, estas propriedades somadas ao estilete frontal que os tabanídeos conseguem inserir nas vítimas, são capazes de gerar bolhas de material hemorrágico por cima das pápulas do prurigo agudo, caracterizando assim a patologia em questão (HADDAD et al., 2020).
Ictiose epidermolítica anular: uma revisão da literatura
Authors: Schroder Gabriele Cristina , Bivar Gabriela Caracilo Carvalho , Lafetá Maria Letícia Lara , Prado Isadora , Rangel Myrela Murad Sampaio Faria
Published: July 2024

A ictiose epidermolítica anular (iea) é uma forma rara de ictiose epidermolítica (ei), manifestada por placas eritematodescamativas, policíclicas e migratórias, acompanhada de ceratodermia palmoplantar. Materiais e métodos: para a elaboração desse artigo foram consultados artigos científicos e artigos de revisão publicados na medline/pubmed e scielo entre 1992 e 2024. Resultados e discussão: a iea foi descrita por sahn et al. Em 1992, como resultado de mutações dominantes nos genes da queratina 1 e 10.  Manifesta-se por placas liquenificadas hiperqueratóticas, com surtos intermitentes de placas anulares e policíclicas. tem como principal diagnóstico diferencial a eritroqueratodermia variabilis progressiva, sendo diferenciadas principalmente pela histologia. Considerações finais: devido a raridade da patologia, as opções de tratamento relatadas ainda são poucas, incluindo retinoides, corticoides tópicos e queratolíticos, com pouca resposta quando tópicos melhores resultados se concentram com o uso de retinoides sistêmicos.
Efeitos da exposição à altitude sobre os aspectos neuropsicológicos: uma revisão da literatura
Authors: Paiva Júnior Walterley de Souza , Silva Renata Reis , Carneiro Pedro H G , Aguiar Luísa Correia de , D’Umbra Isabela Cristina
Published: July 2024

Introdução: Este artigo revisa os efeitos da exposição à altitude sobre os aspectos neuropsicológicos, abordando os impactos cognitivos e comportamentais observados em indivíduos expostos a diferentes altitudes. A pesquisa visa consolidar o conhecimento atual e identificar lacunas na literatura sobre este tema. Materiais, Sujeitos e Métodos: Foram revisados estudos publicados em bases de dados científicas utilizando palavras-chave relacionadas à exposição à altitude e aspectos neuropsicológicos. Os critérios de inclusão selecionaram estudos que investigaram tanto indivíduos saudáveis quanto pacientes com condições clínicas específicas em diferentes altitudes ao redor do mundo. Resultados e Discussão: Os resultados destacam uma variedade de efeitos neuropsicológicos associados à exposição à altitude, incluindo alterações na função cognitiva, humor e desempenho psicomotor. As discussões abordam os mecanismos fisiológicos subjacentes, como hipoxemia e alterações na perfusão cerebral, que podem explicar esses efeitos. Além disso, são discutidas as implicações clínicas e práticas desses achados, como adaptações ambientais e intervenções terapêuticas potenciais. Considerações Finais: Este estudo destaca a complexidade dos efeitos neuropsicológicos da exposição à altitude e a necessidade de abordagens integradas na pesquisa e prática clínica. São sugeridas direções futuras para pesquisa, incluindo estudos longitudinais e intervenções para mitigar os efeitos adversos observados. Conclui-se que uma compreensão mais aprofundada desses efeitos é crucial para otimizar a saúde e o desempenho em populações expostas a diferentes altitudes.
Estrategias efectivas para el desarrollo de la competencia emocional del docente de nivel superior
Authors: Bautista Ericka Paola Rodríguez , Anania Moran Arevalo Angelica , Katherine González Rodríguez Liliana
Published: July 2024

Las investigaciones han constatado que los docentes universitarios enfrentan mayores riesgos, puesto que, se exponen diariamente a un trabajo que requiere alta implicación emocional para abordar diversos desafíos. La presente investigación tiene como finalidad: Explorar las estrategias efectivas para el desarrollo de las competencias emocionales en docentes del nivel superior. La metodología fue cuantitativa de alcance descriptivo-transversal. El muestreo por conveniencia permitió recopilar datos en 30 docentes universitarios mediante una encuesta diseñada con 10 preguntas relacionadas a las variables de estudio. Mientras que el procesamiento de datos se analizó en el software estadístico IBM SPSS. Lo resultados revelan que los docentes, en su mayoría, presentaron aspectos positivos en las competencias emocionales, aunque un grupo minoritario aún requiere fortalecerlas. Asimismo, se identificaron estrategias efectivas de formación y desarrollo profesional, pero persisten desafíos en cuanto al apoyo institucional, lo cual afecta la implementación y efectividad de dichas estrategias para fomentar el desarrollo emocional de todo el cuerpo docente.
Evaluasi Progam Pembelajaran Untuk Pendidikan Inklusif
Authors: Munna Zakiatul , Husna Zikra Al , Rahmi Ulfi
Published: July 2024

Penulisan Artikel ini bertujuan untuk mengevaluasi pelaksanaan program pendidikan inklusi di Sekolah Dasar. Evaluasi program pendidikan inklusi di Sekolah Dasar merupakan upaya untuk memastikan keberhasilan program inklusi dan memberikan kesetaraan bagi siswa dengan kebutuhan khusus untuk berkembang dalam lingkungan yang inklusif. Evaluasi program harus mempertimbangkan berbagai faktor, termasuk keberhasilan bagi siswa inklusi, kenyamanan siswa, kesesuaian program dengan proses pengajaran, tanggapan orang tua, dan ketersediaan segala akses untuk mendukung program inklusi. Ada beberapa bentuk praktik evaluasi yang dapat dilakukan, seperti melakukan observasi kelas inklusi, survei siswa, wawancara dengan guru, pengukuran hasil belajar, dan konsultasi dengan ahli pendidikan inklusi. Setelah dilakukan evaluasi, perlu dilakukan refleksi untuk mengevaluasi kembali proses evaluasi dan mempertimbangkan upaya yang perlu dilakukan selanjutnya. Melalui evaluasi dan refleksi yang tepat, sekolah dapat memperbaiki program yang ada dan memberikan dukungan yang lebih baik untuk siswa inklusi. Hal ini guna memastikan bahwa siswa inklusi dapat belajar dan berkembang dalam lingkungan yang inklusif dan mendapatkan kesempatan yang sama dengan siswa lainnya
The Relationship between Candida Infections and Atherosclerotic Heart Disease
Authors: Ali Alyaa M. ,   Al-Nasiriyah Technical Institute Southern Technical University, Shaqi Ajil Anwar ,   Department of community health / Technical Institute / Nassiriyah, Southern Technical University
Published: July 2024

Background: The purpose of this investigation is to determine whether or not fungus belonging to the genus Candida can be found within atherosclerotic plaques and to examine various immunological and biochemical indices in patients with particular cardiac conditions who also harbour Candida spp. Specifically, here's what to do and how to do it: In order to determine if fungi were present in an atherosclerotic plaque, a specific test was performed. Method: Twenty autopsies revealed a total of 61 atherosclerotic plaques. In addition, 41 persons with atherosclerosis had their blood tested for TNF-α and IgG and IgM antibodies to Candida spp. There were a wide range of ages represented in this group, from 34 to 85 years old, with 28 men and 13 women. Results: The results showed that fungal species belonging to the genus Candida were present in 24.9% (10/41) of atherosclerotic plaques. Candida krusei and C. dubliniensis were the most common types of Candida identified, while occasionally C. tropicalis and C. albicans were discovered. None of the 41 patients tested positive for IgM, although 30 of them (73.1% of the total) did test positive for IgG. There were fewer IgG-negative patients (n=6) with TNF-α than IgG-positive patients (n=11), although the TNF-α levels in the former were significantly greater than those in the latter (511.7pg/ml, p <0.05). It was shown that the discrepancies between ASAT and ALT levels were much larger in patients who tested positive for Candida spp but negative for TNF-α. Conclusion: Candida fungus may contribute to atherosclerosis by inducing inflammation in the lining of blood vessels.
Legal Analysis of the Consumer Protection Law in the Promotion of Alcohol with Ethnic and Religious Elements by Holywings on Instagram
Authors: Octaviona Tania ,   Faculty of Law, Diponegoro University, Putrijanati Aju , Wibawa Kadek Cahya Susila ,   Faculty of Law, Diponegoro University,   Faculty of Law, Diponegoro University
Published: July 2024

Promotional efforts are crucial to a company's marketing strategy. However, Holywings' promotion offering free alcoholic beverages to individuals named Muhammad and Maria violates Law Number 1 of 2024 on electronic information and transactions, specifically Article 28, paragraph 2. This article prohibits spreading information that incites hatred or enmity based on ethnicity, religion, race, and inter-group distinctions (SARA). This research analyzes promotion regulations under this law and the responsibilities of businesses concerning promotions involving ethnic and religious elements, as outlined in Law Number 8 of 1999 on Consumer Protection. Using a normative juridical approach, this study examines literature, secondary data, and statutes to address the legal issues. The research employs qualitative analysis to systematically gather and analyze data, aiming to compile relevant theories, concepts, legal principles, and regulations. The result indicate that legal protection for consumers regarding promotions with ethnic and religious elements is upheld by Article 4, letter g of the Consumer Protection Law, ensuring fair, honest, and non-discriminatory treatment. Additionally, Article 17, Paragraph 1, Letter f prohibits business actors from engaging in such advertising, while Articles 19 and 20 outline their accountability.
The Influence of Parenting Patterns on Smartphone Addiction Among Children of Indonesian Migrant Workers in Johor Bahru, Malaysia
Authors: Nasharuddin Nasharuddin ,   Primary School Teacher Education Program, Faculty of Education, Muhammadiyah University of Makassar, Indonesia, Pratama Sandi , Ramadhani Tri , Ramdaniah Yanti ,   Islamic Education Counseling and Guidance Program, Faculty of Islamic Studies, Muhammadiyah University of Makassar, Indonesia,   Primary School Sekolah Indoneisa Johor Bahru, Malaysia,   Primary School Teacher Education Program, Faculty of Education, Muhammadiyah University of Makassar, Indonesia
Published: July 2024

In the era of globalization and digital technology development, smartphone usage has become an integral part of daily life, including in the context of child-rearing. This research aims to explore the influence of smartphone use on parenting patterns and smartphone addiction levels among Indonesian migrant workers' children at the Indonesian Elementary School in Johor Bahru, Malaysia. The study involved 76 parents and 3 teachers as respondents. Data was collected through interviews and questionnaires, then analyzed using descriptive and inferential methods. The results show that the majority of children use smartphones with frequencies of very often (19%), often (7%), quite often (37%), and rarely (37%), but parental supervision of smartphone use still includes some families in the categories of not supervising (5%), moderately supervising (18%), often supervising (7%), and very closely supervising (70%). The level of parental awareness about the importance of monitoring also varies, with most still lacking awareness of the negative impacts of uncontrolled smartphone use. Pearson correlation analysis shows a significant relationship between effective parenting patterns, such as monitoring and providing alternative activities, with the frequency of smartphone use by children. These findings underscore the importance of a balanced and proactive parenting approach in managing smartphone use to prevent addiction and other negative impacts on children.
The Role of Intrinsic Motivation in Mediating the Effect of Auditor Independence on Audit Quality in Indonesia
Authors: Sanjaya I Gusti Ngurah ,   Departement of Accounting, Faculty Economic and Business, University Warmadewa Denpasar, Amlayasa AA Bagus ,   Departement of Accounting, Faculty Economic and Business, University Warmadewa Denpasar
Published: July 2024

This research aims toempirically testing the role of intrinsic motivation in mediating the relationship between the influence of independence on audit quality. The use of intrinsic motivation as a mediating variable is intended toclarify the influence of various individual characteristics of certain auditors on the quality of the auditor's work. This research was conducted on 110 auditors from various Public Accounting Firms using a snowballing survey approach and Partial Least Square (PLS) analysis with the help of SmartPLS 3.2.9. This research finds that intrinsic motivation is influenced by the auditor's independent attitude and influences audit quality. This research also succeeded in proving that the auditor's intrinsic motivation has moderate influence in mediating the relationship between independence and audit quality. Based on these findings, auditors and public accounting firms are advised to re-evaluate their audit quality through independence and intrinsic motivation. The results of this empirical research have succeeded in proving that audit quality becomes better as a result of the quality of auditor independence, mediated by intrinsic motivation, although the influence is still moderate. The findings support developing agency theory and self-determination theory in explaining the role of in improving audit quality.
Factors Affecting the Health of Ethnic Minorities in China: Enhancingtheir Ability to Counter COVID-19
Authors: Huang Chen ,   Universiti Kebangsaan Malaysia, Nan Dr. Nurul Syafiza Che ,   Faculty Economics And Management,   Universiti Kebangsaan Malaysia;Faculty Economics And Management
Published: July 2024

Coronavirus disease 2019 is a serious public health emergency, and the virus is still mutating and has not yet ended.The global impact of the COVID 19 pandemic is not only limited to the economy, but also includes many other areas, including the lives and health of individuals. The purpose of this study was to investigate the impact of the COVID 19 pandemic on the health of ethnic minorities in China. Due to the lack of relevant literature examining the impact of the COVID 19 pandemic on the health of ethnic minorities in China, this paper attempts to analyse the common factors associated with the increase in the rate of inf ection and the increase in the mortality rate of ethnic minorities in other countries during the pandemic, including healthcare resources, by using a qualitative anal ysis approach and by reviewing a large amount of literature and data from questionnaires t hat have impacted on the health of aboriginal populations during the neo new crown epidemics in other countries, health facilities, income levels and government policies to waive treatment costs, etc., in order to gain insight into the correlation between these factors and the health status of ethnic minorities and their impact on the epidemic, in order to summarise the common factors affecting the health of ethnic minorities in China during the New Crown epidemic. The study found that most indigenous peopl es in other countries suffer from a lack of medical resources due to their remote location, a lack of healthy water sources and sanitation facilities that makes them more susceptible to infection with the Ne w Coronary Virus, as well as a combination of poo r income levels and unhealthy diets that lead to kidney disease and hypertension that add to the mortality rate of the New Coronary condition, and even in a small number of cases, serious mental health prob lems. And China's ethnic minorities also have simi lar social and economic marginalisation and similar living conditions as minorities in other countries. In order to better address this problem, it is recommended that the Government increase investment in medica l resources for ethnic minorities, raise inc ome levels, improve living environments and dietary structures, reduce the probability of kidney disease and hypertension complications by subsidising regular medical check ups for ethnic minorities in China, and help ethnic minorities in China to improve their resistance to the new coronary epidemic, which will be important for improving the health of ethnic minorities in China.
Analysis of the Importance Performance Method on the Quality of Outpatient Pharmacy Services at Guntur Hospital, Garut, West Java - Indonesia
Authors: Dyah Novia ,   Faculty of Economy and Bussiness, Universitas Islam Bandung, Indonesia, Nu’man A Harits , Rahim Agus Hadian ,   Industrial Engineering-Faculty of Engineering, and Departement of Management - Faculty of Economy and Bussiness, Universitas Islam Bandung, Indonesia,   Departement of Management -Faculty Economy and Bussiness, Universitas Islam Bandung, Indonesia
Published: July 2024

Guntur Hospital is a hospital that provides health services and also provides pharmaceutical services. According to Minister of Health Regulation Number 72 of 2016 concerning functions and duties, hospitals must be able to provide quality services. This study aims to determine the level of patient satisfaction with the pharmaceutical services of Guntur Hospital using the five main dimensions of SERVQUAL. Then it is analyzed using importance performance analysis (IPA) to find out items that need to be prioritized for improvement by making a Cartesian diagram and providing recommendations for improving service quality. This research was conducted for 3 months by conducting interviews, observations and questionnaires on outpatients at Guntur Hospital. The research method uses quantitative research with a descriptive approach. Researchers used data collection techniques by observation, interviews, distributing questionnaires and documentation. From the results and discussion, it can be concluded that: The level of customer satisfaction with the quality of services provided at the Guntur Hospital outpatient pharmacy installation, in the dimensions of tangibles, reliability, assurance and empathy, patients stated that they were satisfied with the quality of services provided. Meanwhile, in responsiveness, patients stated that they were not satisfied with the quality of services provided. Then the gap in the quality of pharmaceutical services shows a negative gap value, which means that the expectations of patients in the outpatient pharmacy installation as a whole do not match the patient's perception.
Cultivating Excellence: Formalizing Street Food Enterprises in Bangladesh through Quality Management and Customer Relationship Strategies
Authors: Anwar A.F.M. Kabir ,   Putra Business School, Malaysia, Nadarajah Devika ,   Putra Business School, Malaysia
Published: July 2024

Purpose: Street foods are enjoyed by all walks of life throughout the world. It offers a variety of delicacies, easily accessible and affordable. The street food industry in Bangladesh is of no exception. However, street food vendors in Bangladesh typically come from low socioeconomic backgrounds and lack appropriate understanding of good production methods resulting in poor sanitary standards. The purpose of this study is to examine the prospects for sustainability and growth in Bangladesh's street food business since this sector has great economic potential for the country. Approach: Qualitative research approach was employed by interviewing ten street food vendors. The interviewees were asked on a wide range of questions including their history, understanding of quality management, understanding of customer relationship management, planning and delivery, and the regulatory frameworks under which business is conducted (18 questions in all). Findings: The findings reveal that street food vendors are not well-versed in waste reduction, hygiene, or food quality. They have very limited knowledge on how to manage their customer interactions or develop any skills in this area. Formalization of street food business is observed as a key driver towards sustainability and growth for this sector. Originality: This study brings to light the challenges of street food in Bangladesh arising from weakness in quality management and customer relationship management roadmap. Risk management, contingency planning, training, formal licensing, and audits are critical in order to improve industry sustainability.
Moral and Intellectual Integration in Islamic College
Authors: Ningsih Tutuk ,   UIN Prof. K.H. Saifuddin Zuhri Purwokerto, Kurniawan Heru , Nurbaiti Amalia ,   UIN Prof. K.H. Saifuddin Zuhri Purwokerto,   UIN Prof. K.H. Saifuddin Zuhri Purwokerto
Published: July 2024

The conceptualization of moral and intellectual integration in digital education at Islamic religious universities is carried out by conceptualizing moral and intellectual integration in digital education. Intellectual moral integration is carried out through three basic values, namely religion, responsibility and creativity. Morals and intellectuals are conveyed in digital education by internalizing religious values as a moral and intellectual basis that rests on Islam which regulates human relationships with God; the value of responsibility as an intellectual moral basis that regulates human relations with humans and the universe; and the value of creativity as a moral and intellectual basis that regulates humans' relationships with themselves in the context of developing themselves.
Boosting MSME Global Competitiveness: How Management Knowledge and Performance Interact
Authors: Ariadi Slamet ,   Atma Bhakti College of Economics, Indonesia, Sutianingsih Sutianingsih ,   Atma Bhakti College of Economics, Indonesia
Published: July 2024

This study examines the effects of management competence and knowledge on competitiveness. Through a quantitative approach, the researchers were able to collect data. They selected a sample of 100 individuals. The researchers used various statistical techniques to analyse the data. These included the f-test, linear regression, and determination tests. They discovered that acquiring managerial knowledge and skills significantly boosts performance and can help improve competitiveness. The characteristics of organisational knowledge and skills significantly boost performance. On the other hand, the Sobel test indicates that performance improvement can moderate the link between management competence and competitiveness. The objective of this investigation is to examine the impact of management knowledge and management competence on competitiveness, with performance improvement acting as a mediator. This study uses a quantitative approach to gather data. This study employed purposive sampling to choose a sample of 100 individuals. The data analysis approach employs several methodologies including multiple linear regression analysis, t-test, f-test, and determination test. This researcher demonstrates that the acquisition of management knowledge, proficiency, and performance enhancement have a favourable and noteworthy impact on competitiveness. Management knowledge and skill characteristics exhibit a favourable and substantial impact on enhancing performance. The Sobel test examines how performance improvements moderate the relationship between management knowledge, management competence, and competitiveness.