bluuebunny/crossref_metadata_2025 huggingface dataset:
Nos jardins do CAS
Authors: Francisca Cleidimara da Silva  , Pedrosa Giany Paiva , Mendes Veras Mízia Emanuella
Published: December 2024

A infância é o momento mais marcante quanto ao desenvolvimento motor e cognitivo do ser humano e, por isso, é tão importante tratá-la com respeito e cuidado. Visando uma aprendizagem significativa com base na equidade e foco no conhecimento de mundo, organizou-se um projeto intitulado “Nos Jardins do CAS”, no CAS Mossoró, com nove crianças Surdas na faixa etária entre 4 e 12 anos, que tiveram a oportunidade de conhecer os componentes da fauna e flora locais, suas interações intra e interespecíficas, os impactos dos mesmos no meio ambiente e o papel de cada um dentro dos muros do CAS. A condução do projeto teve início em maio do corrente ano. As crianças foram apresentadas a insetos, aracnídeos, répteis, aves e plantas, observando seu modo de vida, hábitos e peculiaridades. Puderam construir modelos didáticos que as ajudaram na compreensão de conceitos como metamorfose e fotossíntese. Houve o plantio de grãos de feijão, a princípio em copos com  algodão e, posterior- mente, em uma mistura de areia e esterco. Tais plantas foram regadas periodicamente para observação do crescimento e desenvolvimento das mesmas, além de um comparativo relativo à quantidade de água a qual elas eram submetidas. Houve a produção de cartazes e outros instrumentos pedagógicos por meio das próprias crianças, que puderam materializar o conhecimento adquirido através de imagens e palavras escritas na Língua Portuguesa (L2). Por fim, foram gravados vídeos onde as crianças explicam o que aprenderam, seja em relação ao conteúdo ou aos sinais de Libras.
Pequenos pesquisadores da educação bilíngue: curiosidades sobre a natureza e a vida dos insetos
Authors: Honorato Elaine Costa , Graciete Figueiredo
Published: December 2024

Estudar a vida dos insetos é iniciar um processo de conscientização sobre o cuidado com a natureza e o reconhecimento da riqueza deste universo que é minúsculo, mas também carregado de uma grandiosidade fundamental  para o meio ambiente. Pensando na relevância deste conhecimento, este estudo apresenta um relato de uma experiência realizada nos 2.º anos do Ensino Fundamental I do Instituto Nacional de Educação de Surdos, localizado na cidade do Rio de Janeiro, e busca trabalhar a interdisciplinaridade por meio das disciplinas de Ciências, Língua Portuguesa Escrita e Libras. A disciplina de Ciências trabalhou o reconhecimento e a importância dos insetos para o meio ambiente, a identificação do seu habitat natural e o respeito à natureza. A disciplina de Língua Portuguesa trabalhou o desenvolvimento da escrita por meio das curiosidades que o estudo desperta a partir da pesquisa realizada nos espaços da escola durante a observação dos insetos encontrados no INES. A disciplina de Libras trabalhou a ampliação do repertório linguístico e a desenvoltura com a Língua Brasileira de Sinais por meio da apresentação de uma maquete construída pelos estudantes após o estudo do meio no INES. A metodologia utilizada foi a pesquisa em campo para identificar os insetos que habitam o INES. Essa sequência didática proporcionou a escrita de um texto coletivo, a vivência de uma prática pedagógica lúdica por meio da construção de uma maquete e a ampliação da Língua Brasileira de Sinais por meio da apresentação do texto e da maquete
Cidadania religiosa para dissidentes sexuais e de gênero
Authors: Silva Jeferson Batista , Serra Cris
Published: December 2024

Pessoas “católicas LGBTI+” se articulam no Brasil desde a primeira década dos anos 2000. Elas reivindicam a compatibilidade entre sua pertença religiosa e a diversidade sexual e de identidade de gênero. A partir da revisão de literatura e da pesquisa etnográfica, este artigo se centra no forjamento dos chamados “grupos católicos LGBTI+”. Partimos de uma abordagem socioantropológica relacional e processual das ações coletivas desenvolvidas por esses atores, evidenciando processos de disputas e controvérsias, mas também de alianças e parcerias protagonizadas por esses coletivos católicos. Nosso argumento é que a luta por espaço e dignidade nos ambientes eclesiais torna-se mais uma camada na empreitada mais ampla para a conquista de direitos sexuais e de gênero nos espaços políticos da sociedade brasileira. Portanto, quando estabelecem articulações com atores religiosos e não-religiosos, os sujeitos “católicos LGBTI+” criam uma noção de “cidadania religiosa plena”. Por meio de dados etnográficos, afirmamos que essa noção é composta pelo entendimento de que o direito ao sagrado das pessoas dissidentes de sexo e gênero no interior do catolicismo é um direito humano e constitucional.
Una mirada articuladora entre el anclaje y el dinamismo
Authors: Durán Ricardez Ignacio Salvador
Published: December 2024

La presente reseña aborda los principales planteamientos del libro De la religiosidad vivida a la religiosidad bisagra. Experiencias de lo sagrado en el México contemporáneo (Juárez Huet, De la Torre y Gutiérrez, 2023). El principal objetivo es ofrecer una visión panorámica de los aportes que esta obra ofrece al campo de los estudios sobre religiones, con énfasis especial en tres aspectos: su valor como una mirada cualitativa profunda que dialoga con otras aproximaciones previas de corte cuantitativo; la manera en que clarifica la relación entre los estudios de las religiosidad popular en México y el enfoque de la religiosidad vivida; y la propuesta por incorporar la perspectiva de la religiosidad bisagra, como una herramienta heurística para analizar la articulación entre el anclaje a las viejas tradiciones y el dinamismo de las recomposiciones subjetivas. Asimismo, se ofrece una visión esquemática de la estructura del libro, sus objetivos y el contexto en el que se inserta, para brindar una primera aproximación a los lectores interesados.
Paleontologia como ferramenta pedagógica
Authors: Azevedo Hugo José Coelho Corrêa de , Silva Dafny Coutinho do Espirito Santo , Ramos Fernanda Campello Nogueira , Barros Brenno Gomes de
Published: December 2024

Introdução. Paleontologia, a Ciência que estuda a vida pré-histórica por meio de fósseis, tem grande importância no ensino das Ciências Naturais, pois é capaz de promover a compreensão de processos evolutivos e biológicos. No entanto, é raramente abordada nos anos iniciais do Ensino Fundamental, limitando o aprendizado sobre o passado da Terra. Integrar essa Ciência ao currículo pode despertar o interesse científico e desenvolver habilidades como pensamento crítico e alfabetização científica. Objetivo. O objetivo do artigo é relatar uma experiência didática utilizando a Paleontologia para desenvolver leitura, escrita e pensamento científico em alunos do Ensino Fundamental I. Metodologia. Participaram da atividade 36 alunos de 6 a 8 anos. Eles manusearam réplicas de fósseis, levantaram hipóteses sobre a vida dos seres e registraram suas ideias por meio de desenhos e textos, seguidos de discussão coletiva. Resultados. A atividade promoveu o interesse pela Ciência, desenvolveu habilidades comunicativas e estimulou a alfabetização científica contextualizada. Conclusão. O uso de fósseis mostrou-se eficaz para integrar a Paleontologia ao desenvolvimento cognitivo e linguístico, sugerindo a expansão da abordagem para outros temas científicos.
Дводіапазонна монопольна антена з подвійним сенсом, квадратною щілиною та круговою поляризацією, що живиться від копланарного хвилеводу
Authors: Дхара Р. , Рама Сантош В. , Вівек Анді , Шехават Г. С. , Махато С.
Published: December 2024

В роботі розроблено дводіапазонну двосенсову антену з квадратною щілиною та круговою поляризацією, що живиться від копланарного хвилеводу. Спроектована антена містить два додаткових патчі. Змінюючи розміри патчів, можна досягти гарного узгодження імпедансів. У цій антені є дві смуги пропускання за імпедансом IBW (impedance bandwidth) в діапазонах 2,65–5,43 і 5,77–6,19 ГГц, а також дві смуги пропускання за коефіцієнтом еліптичності ARBW (axial ratio bandwidth) в діапазонах 2,88–3,00 і 4,98–5,35 ГГц в межах IBW. Розроблена антена з подвійною смугою пропускання за імпедансом призначена для роботи на резонансних частотах 4,04 і 5,98 ГГц. Вона генерує подвійну смугу кругової поляризації, яка працює на частотах 2,94 і 5,2 ГГц. Це лівостороння кругова поляризація LHCP (left-hand circular polarization) і правостороння кругова поляризація RHCP (right-hand circular polarization). В якості матеріалу підкладки використано недорогий епоксидний матеріал FR4_epoxy з діелектричною проникністю εr = 4,4. Антена спроектована за допомогою програмного пакета Ansoft HFSS. В цьому дослідженні проведені вимірювання, моделювання та аналіз наступних параметрів: коефіцієнт відбиття, ARBW, коефіцієнт підсилення, діаграма спрямованості та ККД випромінювання. Запропонований нижній ARBW діапазон антени може бути придатним для деяких видів бездротового зв’язку в S-діапазоні, а вищий ARBW діапазон може бути придатним для застосування в бездротових локальних мережах WLAN.
THE URBAN METRO TRANSIT’S PERFORMANCE EVALUATION USING SUPER-DEA
Authors: KHURSHEED Salman , YASMIN Shagufta , KIDWAI Farhan Ahmad
Published: December 2024

Urban metro transit systems are essential for socio-economic growth and to the achievement of sustainable urban development. To continuously raise the caliber of services, infrastructure performance must be monitored and evaluated on a regular basis. The effectiveness and efficiency of Delhi’s urban public transit system, i.e., Delhi Metro is investigated using Data Envelopment Analysis (DEA) and Super-DEA approaches. DEA is a non-parametric technique used in the estimation of production functions and has been used extensively to estimate measures of technical efficiency. Super-DEA is a linear optimization technique that calculates the relative efficacy of its decision-making units (DMUs) for a wide range of inputs and outputs. The Delhi Metro's "BLUE" line is studied in the present research considering various demographics factors. The relative rankings of the DMUs were assessed taking into account super-DEA after 630 valid responses to commuter-based questionnaires about demographic, travel time components and quality perception parameters were gathered. Each station along the BLUE line is treated as a DMU when analyzing efficiency. Results revealed efficiency, relative rankings and scores for which improvement strategies are suggested.
A REVIEW OF ADDITIVE MANUFACTURING TECHNOLOGIES AND THEIR APPLICATIONS IN THE MEDICAL FIELD
Authors: Tirnovean Andra , Csoregi Nicolas , Borzan Cristina , Varga Gyula
Published: December 2024

This review paper contains a literature survey about some additive manufacturing technologies and their medical use. Additive Manufacturing is a generic term referring to several technologies used to create physical models or prototype parts based on 3D drawings. Additive Manufacturing models can be used for various testing methods. The paper summarizes the application of Additive Manufacturing Technologies in medicine. It describes the main steps for how to create 3D models for medical applications. Some details can be found on the topics: Data acquisition using medical scanners; Data transformation; Creation of virtual 3D models; Surgical planning and simulation on the virtual 3D model; and Creation of Physical 3D Models for Additive Manufacturing Technologies. 3D physical models can be extremely useful in planning complex surgical interventions, which can be simulated on these models before the actual procedure.
CORRELATION ANALYSIS BETWEEN COMPONENTS OF FORCE AND VIBRATION IN TURNING OF 11SMN30 STEEL
Authors: Namboodri Tanuj , Felhő Csaba
Published: December 2024

Workability of material is defined as the ease of operating on it. 11SMn30 is widely used material in automobile manufacturing industries. Cutting forces have been shown to be the most effective measure for understanding metal machining processes. The forces which helps in performing machining operation also affects the cutting tool, in terms of deformation, bend, wear, which leads to the vibration in the machining system, This article aims to study the correlation between feed, components of cutting forces and components of vibration in turning of 11SMn30 steel grade using dynamometer and MPU6050 sensor.
DETERMINATION OF THE STABILITY PERIOD OF TURNING CUTTERS FOR HEAVY MACHINE TOOLS
Authors: Klymenko Galyna , Vasylchenko Yana , Reva Yevhen , Korchma Dmytro , Boroday Roman
Published: December 2024

To determine the optimal cutting modes under conditions of increased requirements for the stability of technological processes, it is necessary to take into account the value of the tool life with a given probability. In this paper, the stability dependence for prefabricated cutters used on heavy machine tools with maximum diameters Dmax = 1250-2500 mm is specified using the group argumentation method. The study presents a new mathematical model that establishes the relationship between tool fracture resistance and key operational parameters. This model incorporates the probabilistic nature of tool performance, which allows for a more accurate assessment of the impact of part size variation, cutting conditions, and process variability. The proposed relationship facilitates the determination of cutting modes that not only increase tool stability but also ensure the reliability and efficiency of heavy machine tools in industrial environments. This mathematical dependence makes it possible to take into account the variation of workpiece parameters and cutting modes, which is especially important when working with large-sized parts on heavy-duty machine tools. The results of the study are of practical importance for industry, as they make it possible to increase the sustainability and productivity of technological processes.
Analysis of Microgrid Performance, Reliability, and Resilience (AMPeRRe) computational model : novel analytical model to forecast the outcomes of installation power grids
Authors: Nicholson Jessica , Gross Matthew , Herring Daniel , Bozada Thomas
Published: December 2024

Federal facilities, industrial areas, academic campuses, and communities are working to incorporate greater renewable energy sources and energy storage in their power infrastructure. While renewable sources of energy can—and do—support several facilities, uncertainty still exists about how reliably these sources of energy can support small and critical power systems with higher reliability standards, such as Army installations, tactical microgrids, remote community grids, and emergency response power systems. Maintaining reliability is already a significant challenge for power grids, and those that have a high proportion of renewable energy face particular challenges due to their intermittent power production. This technical report addresses the uncertainty by presenting a new computational model called Analysis of Microgrid Performance, Reliability, and Resilience (AMPeRRe). The model forecasts the power availability, fuel consumption, specific resilience factors, and excess energy production of proposed grids that include renewable energy sources and energy storage. If proposed grids are forecasted to lose power availability, users can apply this model to find which resources are needed to achieve 100% power availability and optimize resource quantities for ideal performance outcomes. AMPeRRe significantly reduces the uncertainty around renewable energy and energy storage in power grids and informs the critical resource investment decisions needed to yield improved long-term outcomes.
USACE R&D FY24 Annual Report
Authors:   Engineer Research and Development Center (U.S.)
Published: December 2024

This annual report shares the story of innovation across the USACE enterprise. Led by world-class R&D at the U.S. Army Engineer Research and Development Center, USACE is discovering, developing and delivering engineer solutions in the areas of Civil Works, Warfighter Support, Installations and Operational Environments, and Support for Others.
First Specimen of the Horned Puffin (Fratercula corniculata) in Mexico
Authors: Vargas Jonathan , Pineda-Mendoza Nithzia Y. , Valdés-Peña René A. , Ruiz-Campos Gorgonio
Published: December 2024

A dead and partially decomposed Horned Puffin (Fratercula corniculata) found on the beach near Ensenada, Baja California, on 12 June 2023 represents the first specimen and first definite record of the species for Mexico, as well as the second southernmost. The specimen is preserved in the bird collection of the Universidad Autónoma de Baja California, Ensenada. The late spring/early summer date agrees with the timing of many occurrences of the Horned Puffin along and near the coast of Upper California since the 1970s.
WITHDRAWN: Development of the correlation between mitophagy-related genes and epilepsy
Authors: zheng jingxian , Wang Miao , Zhang Han , An Wen , Xu xiangping
Published: December 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Phytochemical constituent analysis, antioxidative activity, and cytotoxic effects of Caulerpa lentillifera extracts inducing cell apoptosis and sub-G/G0-G1 cell cycle arrest in KON oral cancer cells
Authors: Manmuan Suwisit , Tubtimsri Sukannika , Sirirak Thanchanok , Petchsomrit Arpa
Published: December 2024

Background
The purpose of this study was to explore the anti-cancer properties of Caulerpa lentillifera (C. lentillifera) in order to gain insights into possible treatment approaches. Using the maceration method, which included solubilizing chemicals such as methanol, ethanol, and acetone, C. lentillifera was extracted. The chemical composition of acetone extracts of C. lentillifera was investigated and their anti-oxidative activity was evaluated.
Methods
The phytoconstituents of acetone extracts were screened using the LC-QTOF MS/MS technique, and the cytotoxic effect was assessed using the MTT test. We used Hoechst 33258 and AO double staining to investigate morphological changes and apoptosis, and DAPI and FDA double labeling to look at the nucleus and cytoplasm. Using a flow cytometer, the percentage of cell cycle arrest was calculated and the fraction of cell death was examined.
Results
The LC-QTOF MS/MS analyses results revealed ten main phytochemicals in the acetone extracts. The KON cells exhibited sensitivity to acetone, ethanol, and methanol in that order. By causing ROS-mediated cell death, concentrations of C. lentillifera methanol, ethanol, and acetone extract at IC40, IC60, and IC80 can cause apoptosis and cell death in less than a day. KON cells were prevented from advancing past the sub-G and G0-G1 stages by all three extracts. Furthermore, the extracts significantly impeded colony growth, migration, and invasion. The increase in cellular uptake was measured using the TEER test.
Conclusion
This work advances our understanding of the anti-tumor characteristics of C. lentillifera extract, which will benefit patients suffering from oral cancer.
Landslide Susceptibility Analysis in Kaski District, Nepal: Using Remote Sensing Technique with Intensive Field Verification
Authors: Pokharel Ramjee Prasad , Khanal Narendra Raj , Paudel Basanta
Published: December 2024

Landslide events generally occur rapidly, are frequent, and also unpredictable. The landslide phenomenon often happens in mountainous regions due to natural and anthropogenic factors, which cause massive destruction and turn into disasters, most commonly in the Nepal Himalayas. Steep slopes, events with high-intensity rainfall, deforestation, land degradation, and scouring of river banks by rivers are the major reasons for the occurrence of landslides. Therefore, identification of areas susceptible to landslide occurrences and preparedness planning could help reduce the losses of human lives and properties. This study screens landslide susceptibility in the Kaski district, Nepal, through a Remote Sensing (RS) approach with intensive site verification. The spatial datasets obtained from the analysis of satellite images and other relevant maps were analyzed through a Geographic Information System (GIS). Seven landslide trigger parameters, i.e., slope, aspect, rainfall, land use land cover, drainage density, fault line, and road distance, were taken into consideration. The results were verified using the field observation method. The result shows that about 6.83% of the area is under very high susceptibility, 25.77% under high susceptibility, and 29.6% of the area is located within the moderate landslide susceptibility zones. All these zones are at risk of landslides; therefore, effective mitigation and adaptation measures such as control of human occupation, including the construction of infrastructures and landslide control measures, need to be designed and implemented to reduce the losses and damages from landslides.
EHR Satisfaction Among Physicians: Analyzing the Influence of System Features and User Demographics
Authors: Sulley Saanie , Ndanga Memory
Published: December 2024

Patient care and practice management have both been enhanced through the use of integrated EHR systems in healthcare. Physician satisfaction with EHR systems varies substantially due to disparities in system features and user demographics. Objective This study investigates physician satisfaction with EHR systems, focusing on factors such as e-prescribing, CPOE, interoperability, and customization. It also investigates the relationship between physician age, medical degree type, and satisfaction levels. Methods We used the 2018–2021 National Electronic Health Records (NEHR) data from the National Center for Health Statistics (NCHS). The study included doctors utilizing EHR technology that responded to the NEHR survey. Descriptive statistics, correlation analysis, multivariate regression, and interaction analysis were employed with Python to examine the connections between EHR satisfaction and the independent variables. Results EHR satisfaction is most influenced by the frequency of e-prescribing (β = 0.414, p < 0.001), with CPOE usage also contributing (β = 0.096, p < 0.001). System interoperability had a slight, negative effect on satisfaction (β = -0.031, p < 0.001). Physicians aged 50 and above expressed lower levels of satisfaction with EHR systems than their younger counterparts. Specific EHR systems, like Epic and Cerner, were associated with higher satisfaction levels for all age groups. Conclusion This study highlights the role of specific EHR features such as e-prescribing and CPOE in boosting physician satisfaction. Considering the age factor, physician demographics significantly influence EHR satisfaction among older physicians. Implementing data sharing with a focus on usability is essential for ensuring user satisfaction amidst interoperability challenges. Applying these insights can improve the user-friendliness of EHR systems, boosting adoption and efficiency in healthcare delivery.
Decade of Carbapenemase-Producing Enterobacterales in New Caledonia: Integrative Surveillance Though Genomic, Phenotypic and Clinical approaches
Authors: Colot Julien , Bourles Alexandre , Cousin Léo , Delvallez Gauthier , Biron Antoine , Ruge Tiffany , Bonnin Rémi , Dortet Laurent , Brisse Sylvain , Palma Federica , Saliou Philippe , Objois Thibaut , Kainiu Malia , Pot Matthieu , Veyrier Frédéric , Goarant Cyrille
Published: December 2024

Carbapenemase-producing Enterobacterales (CPE) have been identified by the World Health Organization as global priority pathogens. The dissemination of these bacteria and outbreaks within healthcare facilities are of serious concern. This study investigated the transmission patterns and genetic characteristics of CPE isolated in New Caledonia from 2013 to 2022. The isolates were identified and characterized both phenotypically and whole-genome sequencing (WGS). In total 214 CPE were isolated: 199 non duplicate clinical isolates from 164 patients and 15 from hospital environmental surface. The most common genera in clinical samples were Enterobacter (34%) and Klebsiella (25%), with 194 isolates (98%) carrying IMP-type carbapenemase. WGS of 89 isolates revealed the dominance of the blaIMP-4 carbapenemase gene, found in 82 isolates. The blaIMP-4 was primarily predicted to be carried by IncL/M-type plasmid, found in 69% of the sequenced isolates. Our work revealed the circulation of 12 bacterial clusters with 61 strains involved in outbreaks or persistent over time. Genomic, phenotypic and clinical approaches identified 12 distinct outbreaks involving IMP producers. These results highlight the importance of studying plasmid transmission to better prevent silent spread of CPE. Ultimately, this study provides new guidelines for limiting the clinical spread of CPE in New Caledonia.
Probing the Dark Chemical Matter Against PDE4 for the Management of Psoriasis Using in-Silico and in-Vivo Approach
Authors: B Swapna. , Kotha Satvik , Selvaraj Divakar , setty S Ramachandra , Acharya Aruna
Published: December 2024

The potential downsides of standard treatments of Apremilast and Roflumilast include gastrointestinal side effects, the risk of mental episodes, and drug interactions, among other things. The rationale of the study is to pay attention to global efforts by describing currently underexplored chemical space regions. The objective was to investigate PDE4D inhibitors utilizing the dark chemical database. The goal was to address this by conducting a computational analysis that coupled docking with molecular dynamics, phase screening, and compound pharmacokinetics optimisation utilizing machine learning and artificial intelligence, which are key parts of drug discovery and development processes. We established the binding mode and critical residues (GLN-369, ILE-336, PHE-340, and PHE-372) involved in interactions with 1,39,353 dark chemical matter molecules out of which 15 hits were obtained and subjected to artificial intelligence (PK parameters) and MD simulations. RMSD and stable amino acids interact with four promising molecules 027230, 060628, 060576 and 085881. The ligand 085881 was found promising since it inhibits both IL-6 and TNF-alpha with IC50 of 18.41 µM and 34.43 µM respectively. In-vivo Erythema grading showed that 085881 test substances possess mild to moderate antipsoriatic action.
Osteonecrosis of the Femoral Head: treatment before the collapse. Experience with decompression and biological therapy
Authors: Lara-Taranchenko Yuri , Mimendia Iñaki , Ojeda Víctor Barro , Guzmám María , Hernández Margalida , Martínez Andrés Aliaga , Soza Diego , Collado Diego , Farfán Ernesto Guerra , Hernández Alejandro
Published: December 2024

INTRODUCTION
Osteonecrosis is a disabling condition and one of the most frequent causes of hip arthroplasty in the young population. Early detection and treatment in stages prior to femoral head collapse are essential to prevent progression and conversion to total hip arthroplasty (THA). The present study aims to demonstrate the results obtained in the treatment of patients with initial stages of ONFH, treated with a decompression system that associates biologic therapy (platelet-rich plasma and mesenchymal stem cells) (PERFUSE).
METHODOLOGY:
Retrospective unicentric study in which all patients with ONFH treated with decompression of the necrotic area and biological therapy between May 2018 and May 2023, were collected. Demographic data of the patients (age and gender), risk factors for AVN, area of necrosis (Kerboul), ARCO classification, collapse rate and conversion to THA were obtained.
RESULTS
24 patients with ONFH were treated using the PERFUSE system. The mean age was 47.67 years old, and the mean follow-up was 26.1 months. The mean improvement in the modified Harris Hip Score (mHHS) was 10.11 (from 70.79 to 80.56; p = 0.018). Patients who developed femoral head collapse had worse mHHS scores. 6 patients (25%) progressed to femoral head collapse, of which 2 (8.33%) were converted to total hip arthroplasty (THA). The probability of collapse-free survival at 12 months was 90.9% (SD 6.2; 95%CI, 79.5–100%), and at 18 months it was 85.2% (SD 8.0; 95%CI, 70.9–100%), and at 24 months it was 65.7% (SD 11.7; 95%CI, 46.3–93.2%).
CONCLUSION
Core decompression with bone aspirate marrow and platelet-rich plasma can enhances bone regeneration and delays femoral head collapse, especially when implemented in early-stage ONFH. In this sense, combining both, core decompression with biological support can offer a promising approach for managing early-stage ONFH. Despite encouraging outcomes, further research is needed to optimize treatment protocols and evaluate long-term efficacy.
Knowledge and Practice of Solid Healthcare Waste Management Among Waste Handlers in Hospitals in Southern Ghana: A Qualitative Study.
Authors: Affordofe Michael , Udofia Emilia A. , Koranteng Francis Ofosu , Tettey Prudence , Botwe Paul K. , Akyeampong Enoch , Andoh Theresah , Peprah Elijah Kwasi , Attah Hope Yaw , Tabong Philip , Boateng Godfred , Quansah Reginald
Published: December 2024

Background
Despite Ghana's healthcare waste management guidelines, improper solid waste management remains a public health concern. Although there is extant evidence of the knowledge and practices of healthcare waste management among medical waste handlers elsewhere, evidence in Ghana is sparse. This study sought to assess the knowledge, and practices of waste handlers involved in solid healthcare waste management in selected health facilities in Accra, Ghana.
Methods
This study employed a descriptive phenomenology study design. We conducted three levels of sampling: facility-level sampling, departmental sampling, and a sample of study participants. We recruited medical waste handlers from Korle Bu Teaching Hospital, Tema General Hospital, and Shai-Osu-Doku Hospital for the study. To facilitate the discussion, we used a focus group discussion guide. We transcribed the audio-recorded interviews and uploaded the data into NVivo 14 software for coding. We synthesized the output into themes, sub-themes, and verbatim quotes to bolster the narrative.
Results
While the Waste handlers could describe the different types of healthcare waste, they could not label the colour codes according to the national colours used to identify the waste to be placed in a particular liner and container. In many cases, there was no attempt at managing infectious and sharp wastes, which resulted in needle pricks, falls, or even injuries due to poor transport systems. Although they were not familiar with the treatment processes for healthcare waste, they were aware of the frequency of bin cleaning. Most of the Waste handlers lacked infection-fighting vaccinations. Personal protective equipment, colour-coded bags, and a supply of disinfectants/soap needed to be improved.
Conclusions
Waste handlers are central to effective healthcare waste management and must be more adequately informed and protected against infections. Targeted training programs should be organized for health workers, emphasizing the importance of proper waste disposal and safety protocols to improve healthcare waste management practices.
Prognostic significance of NUAK1 and its association with immune infiltration in stomach adenocarcinoma
Authors: Ni Xin , Pan Fan , Lang Yakun , Zhang Wei
Published: December 2024

BACKGROUND: Stomach adenocarcinoma (STAD) represents a significant global health burden, accounting for a considerable proportion of cancer-related mortalities, and NUAK1, a protein kinase, plays a crucial role in cellular metabolism, cell cycle regulation, migration, and tumor progression. However, its relationship with prognosis and immune infiltration in STAD has not been thoroughly investigated.
METHODS: RNA sequencing data from the Cancer Genome Atlas (TCGA) and Genotypic Tissue Expression Project (GTEx) databases were employed to assess disparities in NUAK1 expression between STAD tumour and normal tissues. Additionally, we investigated the correlation between NUAK1 expression and patient prognosis, in addition to the level of immune cell infiltration. The potential functions were elucidated through an examination of the Gene Ontology (GO) Encyclopedia, the Kyoto Encyclopedia of Genes and Genomes (KEGG), and an enrichment analysis (GSEA).
RESULTS: Our analysis demonstrated that NUAK1 expression in tumour tissues exhibited a notable disparity from that observed in normal tissues, with elevated levels detected in STAD tissues. An elevated NUAK1 expression level was found to correlate with a poorer overall survival (OS), disease-specific survival (DSS), and progression-free intervals (PFI). Additionally, immune infiltration analysis indicated a significant positive correlation between NUAK1 expression and various tumor-infiltrating immune cells, while a negative correlation was observed with T helper cell 17(Th17) cells. Furthermore, enrichment analysis was conducted to identify relevant biological features and pathways.
CONCLUSION: The expression levels of NUAK1 are significantly increased in STAD, and this heightened expression correlates with diminished OS, DSS, and PFI among affected patients. These observations indicate that NUAK1 has the potential to function as a prognostic biomarker for STAD and may represent a viable therapeutic target for intervention in its management.
Identification of dengue risk-prone areas using multicriteria decision-making model and machine learning algorithm in Kolkata and Howrah Municipal Corporation areas
Authors: Naskar Suvankar , Biswas Brototi , Das Jayanta , Osman Shuayb Abdinour
Published: December 2024

Dengue fever poses a critical global health challenge, particularly in tropical and subtropical regions. Accurate identification of dengue-prone areas is essential for effective prevention and control. West Bengal, India, has witnessed significant dengue outbreaks, with the Kolkata-Howrah Municipal Corporation (KMC) area being the most affected. This study presents a novel approach, comparing Machine Learning (ML) and Multi-Criteria Decision Making (MCDM) techniques, to create a dengue susceptibility zonation model. We leverage diverse datasets, including environmental variables, demographic variables, and historical dengue incidence records collected through primary surveys. The models are built using the Fuzzy Analytic Hierarchy Process (F-AHP) and Random Forest (RF) algorithms, and their performance is assessed through Receiver Operating Characteristic (ROC) curve analysis, yielding Area Under the ROC Curve (AUC) values. While both models achieve similar AUC values, they produce different zonation patterns. Random Forest generates a dispersed susceptibility map, while F-AHP yields a more concentrated pattern. Remarkably, Random Forest identifies high-risk zones effectively, with approximately 21.69% of dengue cases occurring in these areas, compared to 4.35% in the F-AHP model. These zonation maps are invaluable for decision-makers, health authorities, and disaster management teams, aiding in proactive measures to curtail dengue spread and reduce mortality. This study underscores the power of ML techniques in predicting dengue susceptibility zones, reinforcing existing knowledge of dengue risk factors. By bridging advanced data analysis with practical applications, we advance dengue prevention and control efforts in West Bengal, offering insights that could benefit regions grappling with similar challenges worldwide.
Status of partial and complete edentulism and restoration and associated factors in Guangdong adults: a cross-sectional survey in 2021
Authors: Li Bingchun , Yin Luopin , Ye Shu , Li Jianbo , Lu Caihong
Published: December 2024

Background: The completeness of dentition serves as a key indicator for evaluating oral health and functionality within the middle-aged and elderly population. The study uses data from the epidemiological survey on oral health in Guangdong province among middle-aged and elderly individuals to investigate the status of tooth loss and denture restoration, explore the associated influencing factors, and provide fundamental data for oral health studies.
Methods: This study was a cross-sectional survey targeting adults aged 35-44 and 65-74 in 13 cities in Guangdong Province, conducted between 2021 and 2022. The status of tooth loss and denture restoration was investigated. T-tests, Chi-square tests, and ANOVA were used to analyze the differences in the number of individuals with partial or complete edentulism, the number of missing teeth, and the restoration rate between the two age groups. Chi-square tests and binary logistic regression were employed to analyze the risk factors. SPSS 20.0 software was used for statistical analysis of the survey data, p-value of≤0.05 was considered statistically significant.
Results: A total of 824 individuals participated in this survey, including 392 males and 432 females, 445 residents (54.0%) had partial tooth loss, including 206 males and 239 females, 9 individuals (1.1%) had complete tooth loss, comprising 6 males and 3 females. The prevalence of tooth loss was higher in the 65-74 age group compared to the 35-44 age group (p=0.012). The molar region is the most common area for missing teeth in both age groups. The 65-74 age group exhibits a higher number of missing teeth in the incisor, premolar, and molar regions compared to the 35-44 age group, with statistically significant differences in the number of missing teeth observed in each of these regions between the two age groups (p≤0.001). Different age groups, levels of education, regions, periodontal pockets, and the use of cleaning aids affected the prevalence of partial and complete edentulism. The restoration rate is higher in the 65-74 age group compared to the 35-44 age group (p≤0.001), and rural residents exhibit a lower restoration rate than urban residents (p≤0.001). Different age groups, county areas, and diabetes have an impact on whether teeth are restored.
Conclusions: The prevalence of tooth loss among adults in Guangdong Province remains at a relatively high level. This may be associated with factors such as age, education level, geographical location, periodontal health, and the use of wrong interdental cleaning aids. Therefore, there is a continued need to enhance oral health education among the population in Guangdong, emphasizing the importance of using proper interdental cleaning aids to maintain dental health.
Guiding the Scroll: How to Effectively Regulate Reproductive Health Information on social media?
Authors: Pandey Deeksha , Inukollu Pranadeep , Alla Mounika , velaga Sirisha , Pothyil Dan Issac , Nair Rema V
Published: December 2024

Introduction: In women, health literacy has the potential to profoundly affect numerous aspects of reproductive healthcare.This qualitative study seeks to explore healthcare providers' perspectives on the impact of social media on women’s reproductive health literacy and to identify strategies for improving and regulating this rapidly evolving domain.
Material & Methods: This study was conducted in a span of ten months (from October 2023 to July 2024), with a qualitative descriptive design. In the final analysis, 43 participants (11 postgraduates, 21 undergraduates and 11 consultants) were included, as by then saturation was reached.
Results: Four key themes emerged from the analysis of the data with seventeen subthemes. The key themes included A. Content alert: Accuracy and censorship information, B. Credibility and verification, C. Enforcement and penalties, D. Education, accreditation and ensuring quality.
Conclusion: As misinformation continues to proliferate in digital spaces, it becomes increasingly vital to establish effective regulatory frameworks. Implementing well-considered measures across all three levels of control—content creators, consumers, and platforms—can significantly enhance the quality and reliability of health information shared online. By fostering collaboration among these stakeholders, we can create a more informed public and mitigate the risks associated with misleading reproductive health information in social media environments.
The Predictive Value of Combined Nutritional Risk Screening (NRS 2002) and Inflammatory Markers for the Efficacy of Non-Small Cell Lung Cancer (NSCLC) Patients Treated with Immune Checkpoint Inhibitors (ICIs)
Authors: Liu Jianying , Liu Jiaxin , Chen Haiyan , Zhang Qingwei , Zhang Peihong , Chen Zhisheng , Lu Xuefeng , Xu Yijiao
Published: December 2024

Background
In the treatment of non-small cell lung cancer (NSCLC), immune checkpoint inhibitors (ICIs) have markedly improved patient survival, yet some patients do not benefit. The existing prognostic factors are limited, highlighting the development of reliable and convenient predictive indicators.
Methods
A retrospective analysis was performed on 219 NSCLC patients treated with ICIs from June 2019 to January 2024. The nutritional risk screening (NRS 2002) and the neutrophil-to-lymphocyte ratio (NLR) were employed to evaluate the patients' nutritional status and inflammatory response, aiming to investigate the correlation between these markers and treatment outcomes.
Results
The median follow-up duration was 29 (IQR: 25.96–32.04) months. The median progression-free survival (mPFS) and median overall survival (mOS) in the high nutritional risk (NRS2002 ≥ 3, 23.74%) group were significantly lower than those in the low nutritional risk group (mPFS: 2.5 vs 16 months; mOS: 8 vs 16 months, both P < 0.001). Similarly, patients with high NLR values (> 4.92) had significantly shorter OS and PFS than those with low NLR (≤ 4.92) values (mOS: 7 vs 18 months; mPFS: 3 vs 17 months, both P < 0.001). Multivariate Cox analysis revealed that a high NRS 2002 score (HR = 2.73, 95% CI: 1.66 ~ 4.48, P < 0.001) and high NLR (HR = 2.79, 95% CI: 1.65 ~ 4.70, P < 0.001) were independent predictors of poor prognosis. Risk stratification was performed using a combined scoring system of NRS 2002 and NLR (0 points - low risk, 1 point - moderate risk, 2 points - high risk), and it was found that as the risk score increased, OS and PFS significantly decreased. The utility of the combined NLR and NRS2002 scoring model was assessed using a time-dependent receiver operating characteristic (ROC) curve, with results indicating that at 12 months, the AUC value of the combined scoring model was 0.81 (CI: 0.72–0.90). At 24 and 36 months, the AUC values were 0.73 (CI: 0.66–0.80) and 0.70 (CI: 0.64–0.76), respectively. Moreover, the nomogram model exhibited high predictive accuracy in predicting survival prognosis, with AUC values of 0.84 (CI: 0.77–0.91), 0.85 (CI: 0.79–0.91), and 0.78 (CI: 0.69–0.88) at 12, 24, and 36 months, respectively.
Conclusion
The combined NRS 2002 and NLR scoring can serve as an effective prognostic tool for NSCLC patients receiving ICIs treatment. This scoring system helps clinicians more accurately identify patients who will benefit from immunotherapy, thereby facilitating more personalized treatment plans.
Impact of upper tract urothelial carcinoma on patients with non-muscle-invasive bladder cancer undergoing intravesical chemotherapy
Authors: Ji Jiaxiang , Wang Fei , Lai Chin-Hui , Wang Mingrui , Hu Haopu , Xu Kexin , Xu Tao , Hu Hao
Published: December 2024

Background: This study was designed to evaluate the impact of upper tract urothelial carcinoma (UTUC) history on prognosis in patients with non-muscle-invasive bladder cancer (NMIBC) receiving intravesical chemotherapy.
Methods: We conducted a single center, retrospective, cohort study of 444 NMIBC patients who received intravesical chemotherapy after transurethral resection of the bladder cancer (TURBT) at Peking University People's Hospital from 2000 to 2015. Patients were divided into UTUC-NMIBC group (with UTUC history) and primary NMIBC group (without UTUC history) by presence of previous UTUC. Demographic, clinical and pathologic factors were analyzed. Kaplan–Meier curves and the log-rank test were used to depict and compare recurrence-free survival (RFS) and progression-free survival (PFS) between the two groups. Multivariable Cox regression models were constructed to determine the variables associated with RFS and PFS.
Results: Compared to the primary NMIBC group (n = 410), the UTUC-NMIBC group (n = 34) had an older median age [72.0 (65.0–81.0) vs 66.0 (58–75) years; P = 0.007], a higher incidence of multiple tumors (52.9% vs 33.9%; P = 0.026) and a higher recurrence rate (52.9% vs 30.7%; P = 0.008) and worse RFS (P < 0.001). In multivariate analysis, UTUC history was an independent risk factor for recurrence (hazard ratio = 2.242; P = 0.001), but not for progression. Interestingly, subgroup analysis indicated patients with recent UTUC history (≤ 24 months between UTUC and NMIBC diagnoses) were associated with increased recurrence rates (73.7% vs 26.7%; P = 0.014) .
Conclusion: Presence of UTUC history was an independent risk factor for recurrence in patients with NMIBC who received intravesical chemotherapy, especially in those with a shorter interval between UTUC and NMIBC diagnoses.
Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease
Authors: Benetti Acaris , Ribeiro-Silva Joao Carlos , Gómez Luz M. , Tavares Caio A. M. , Bensenor Isabela J. , Lotufo Paulo A. , Titan Silvia M. O. , Girardi Adriana C. C.
Published: December 2024

Background
Experimental studies have shown that urinary dipeptidyl peptidase 4 (uDPP4), unlike serum DPP4 (sDPP4) activity, correlates with proteinuria, serum creatinine, and left ventricular (LV) hypertrophy in 5/6 nephrectomized rats, suggesting a potential role for uDPP4 in chronic kidney disease (CKD) progression. This study investigated the relationship of uDPP4 and sDPP4 activities with renal, cardiovascular, and metabolic function markers, along with mortality and initiation of kidney replacement therapy (KRT) events in individuals with CKD.
Methods
We analyzed DPP4 activity in the urine and serum of 426 participants from the Brazilian CKD cohort, PROGREDIR. Participants were divided into tertiles based on uDPP4 and sDPP4 activities. Multivariable linear regression models, structural equation modeling, Kaplan-Meier survival analysis, and Cox proportional hazard regression models were utilized.
Results
uDPP4 activity was associated with albuminuria, urinary retinol-binding protein 4, LV mass, and type 2 diabetes, but inversely with body mass index and use of renin-angiotensin system blockers. In contrast, sDPP4 activity correlated only with age and biological sex. Higher uDPP4 activity was associated with a higher incidence rate of all-cause mortality (p < 0.0001). Participants in the intermediate and highest uDPP4 activity tertiles had increased mortality risk (HR 2.03, 95% CI 1.46–3.04 and 2.48, 95% CI 1.67–3.67 for T2 and T3, respectively), compared to those in the lowest tertile, even after controlling for potential confounders. Conversely, sDPP4 activity did not correlate with an increased risk of death or KRT in CKD.
Conclusion
These findings support uDPP4's involvement in CKD progression and its association with increased mortality risk in CKD.