bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges for palliative care in times of COVID-19: a scoping review
Authors: Lourenço Marisa , Gomes Tânia , Araujo Fátima , Ventura Filipa , Silva Rosa
Published: March 2024

Introduction

Many of the essential practices in palliative care (PC) had to be adapted to the COVID-19 pandemic. This global spread of the infectious respiratory disease, caused by SARS-CoV-2, created unprecedented obstacles. The aim of this research was to comprehensively assess the experiences and perceptions of healthcare professionals, individuals, and families in palliative and end-of-life situations during the COVID-19 pandemic.

Methods

A scoping review was conducted using the databases CINAHL Complete, MEDLINE, Scopus, SciELO, Cochrane Central Register of Controlled Trials, Psychology and Behavioral Sciences, MEDIClatina, and Portugal’s Open Access Scientific Repository. The review followed the JBI® methodological approach for scoping reviews.

Results

Out of the initially identified 999 articles, 22 studies were included for analysis. The deprivation of relationships due to the safety protocols required to control the spread of COVID-19 was a universally perceived experience by healthcare professionals, individuals in PC, and their families. Social isolation, with significant psychological impact, including depersonalization and despair, was among the most frequently reported experiences by individuals in palliative situation. Despite healthcare professionals’ efforts to mitigate the lack of relationships, the families of these individuals emphasized the irreplaceability of in-person bedside contact.

Systematic review registration

https://osf.io/xmpf2/.
Evaluating the feasibility of constructing shopping centers on urban vacant land through a spatial multi-criteria decision-making model
Authors: Khosravian Jafar , Qureshi Salman , Rostamzadeh Sajedeh , Moradi Bahare , Derakhshesh Parisa , Yousefi Samin , Jamali Keyvan , Ahmadi Reyhaneh , Nickravesh Fatemeh
Published: March 2024

Shopping centers are among the major economic and commercial places in cities in terms of social function, urban sustainability, environment, etc. Therefore, it is crucial to determine suitable locations for building new shopping centers. In this regard, urban vacant lands can be considered as high-potential locations to transform the urban landscape and enhance socio-economic development. The main purpose of this study is to assess the potential of urban vacant lands based on a spatial multi-criteria decision-making (SMCDM) system for building shopping centers in 22 districts of Tehran. In this study, first, 16 effective spatial criteria for locating the new shopping centers were identified using expert opinions and a literature review. The best-worst method (BWM) and the Min/Max method were used to calculate the weight and standardized values of each criterion. Then, the ordered weighted averaging (OWA) method was used to prepare a potential map of urban vacant lands for the construction of a shopping center under different decision-making scenarios, including very optimistic, optimistic, intermediate, pessimistic, and very pessimistic. Finally, the spatial distribution of potential locations in the 22 districts of Tehran was investigated. The results showed that among the different criteria, the distance from the highway networks and distance from public transportation stations had the most weight, whereas the distance from fault and distance from stream networks had the least weight. The number of vacant lands with a very high potential for building a shopping center in Tehran based on very pessimistic, pessimistic, intermediate, optimistic and very optimistic scenarios was obtained at 29, 95, 105, 122, and 224, respectively. An increase in the degree of optimism in the attitude of decision-makers or investors increased the number of available options in the very high potential category. Under all scenarios, all vacant lands in 10 of Tehran’s 22 districts with very high potential for building shopping centers. The results of the proposed model in this study can be useful and practical for a wide range of planners, decision-makers, and investors with different mental attitudes and risk tolerance. Close attention to these results can contribute to achieving sustainable urban development.
Transplantation of a free fillet flap from discarded fingers for repair of a finger pulp skin defect: a case report
Authors: Zhou Xianting , Zhang Chenxi , Fan Xuekai , Cai Xiaoming , Wang Xin , Pan Jiadong
Published: March 2024

Background

Replantation represents a treatment option for patients with severed finger pulps. However, in some cases, replantation is a challenging task.

Case presentation

We report a successful case of finger pulp reconstruction of the ring finger using free flaps from a nonreplantable index finger in a spare-parts procedure. A 43-year-old worker accidentally injured the index, middle and ring fingers of his left hand on a machine turntable. The severed index and middle fingers and the distal pulp of the ring finger could not be replanted in situ due to extensive contusion of blood vessels and soft tissues. After vascular and nerve anastomosis, a free skin flap isolated from the nonreplantable index finger was transplanted to the wound of the distal pulpal defect of the ring finger. The flap survived completely postoperatively. Six months after the operation, only a slight deformity of the ring finger was observed. Moreover, sensation of the digit recovered well.

Conclusions

Spare-part surgery is a surgical approach that effectively saves and utilizes tissue that would otherwise be discarded in cases of severe limb trauma. This idea may be applied to treatment of severe injuries to multiple fingers. Additionally, in the process of tissue transplantation and repair, attention should be given to protecting the tissue in the recipient area to avoid damage to the original undamaged tissue structure, which can adversely affect healing and recovery of the tissue.
Lung microdialysis and in vivo PK/PD integration of cefquinome against Actinobacillus pleuropneumoniae in a porcine experimental lung infection model
Authors: Chen Yuqin , Li Min , Su Dehai , Xiong Shiyu , Feng Youshu , Deng Qin , Ding Huanzhong
Published: March 2024

This study aim to explore the application of microdialysis in pharmacokinetic (PK) and pharmacodynamic (PD) integration of cefquinome against Actinobacillus pleuropneumoniae in a porcine experimental lung infection model. The model was established via intratracheal inoculation where average bacterial counts (CFU) in the lungs of infected pigs reached 6.57 log10 CFU/g after 3 h. The PK profiles of unbound cefquinome in lung dialysates were determined following intramuscular injection of single doses of 0.125, 0.25, 0.5, 1, 2, and 4 mg/kg. Lung dialysate samples were collected using microdialysis at a flow rate of 1.5 μL/min until 24 h. The PD studies were conducted over 24 h based on 10 intermittent dosing regimens and total daily doses ranged from 0.25 to 4 mg/kg and dosage intervals included 12 and 24 h. The lung tissue was collected after 24 h of treatment and homogenized for bacterial counts. The relationships between PK/PD parameters derived from lung dialysates and drug efficacy were analyzed using an inhibitory sigmoid Emax model. The percentage of time the free drug concentration exceeded the minimum inhibitory concentration (%fT > MIC) was the PK/PD index best describing the antimicrobial activity (R2 = 0.96) in the porcine experimental infection model. The %fT > MIC values required to achieve net bacterial stasis, 1, 2 and 3 log10 CFU/g reductions in the lung were 22.45, 28.86, 37.62, and 56.46%, respectively. Cefquinome exhibited time-dependent characteristics against A. pleuropneumoniae in vivo. These results provide valuable insights into the application of microdialysis in PK/PD integration model studies and optima regimen of cefquinome for the treatment of porcine respiratory diseases caused by A. pleuropneumoniae.
Adaptative Strategy of Immunosuppressive Drugs Dosage Adjustments When Combined With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients With COVID-19
Authors: Boland Lidvine , Devresse Arnaud , Monchaud Caroline , Briol Sébastien , Belaiche Stéphanie , Giguet Baptiste , Couzi Lionel , Thaunat Olivier , Esposito Laure , Meszaros Magdalena , Roussoulieres Ana , Haufroid Vincent , Le Meur Yannick , Lemaitre Florian
Published: March 2024

Nirmatrelvir/ritonavir is a promising option for preventing severe COVID-19 in solid organ transplant recipients with SARS-CoV-2 infection. However, concerns have arisen regarding potential drug interactions with calcineurin inhibitors (CNI). This two-phase multicentre retrospective study, involving 113 patients on tacrolimus and 13 on cyclosporine A, aimed to assess the feasibility and outcomes of recommendations issued by The French societies of transplantation (SFT) and pharmacology (SFPT) for CNI management in this context. The study first evaluated adherence to recommendations, CNI exposure, and clinical outcomes. Notably, 96.5% of patients on tacrolimus adhered to the recommendations, maintaining stable tacrolimus trough concentrations (C0) during nirmatrelvir/ritonavir treatment. After reintroduction, most patients experienced increased C0, with 42.9% surpassing 15 ng/mL, including three patients exceeding 40 ng/mL. Similar trends were observed in cyclosporine A patients, with no COVID-19-related hospitalizations. Moreover, data from 22 patients were used to refine the reintroduction strategy. Modelling analyses suggested reintroducing tacrolimus at 50% of the initial dose on day 8, and then at 100% from day 9 as the optimal approach. In conclusion, the current strategy effectively maintains consistent tacrolimus exposure during nirmatrelvir/ritonavir treatment, and a stepwise reintroduction of tacrolimus may be better suited to the low CYP3A recovery.
An Ecological Weed Control Strategy in Paddy Fields: Light Interception from Duckweed Mulching
Authors: Xu Shuhan , Wang Feng , Ding Yuling , Liu Wenchao , Lan Yiyu , Jia Qingqing , Sun Peng , Sha Zhimin
Published: March 2024

Rice–duckweed coculturing as an advanced technique has proven effective for weed control. However, the complex environmental interactions underlying its effectiveness remain unclear. In this study, a controlled pot experiment was conducted to isolate the shading effect of duckweeds (Landoltia punctata and Spirodela polyrhiza) from their intricate environmental interactions with paddy weeds (Cyperus difformis, Eclipta prostrata, and Ammannia auriculata). The results revealed that as the duckweeds grew, there were notable decreases in total weed density (52.41–77.01%) and biomass (42.33–99.23%) while rice biomass remained unaffected. Duckweed covering allowed less than 8.64% of light to pass through and led to decreases in environmental temperature, pH, and dissolved oxygen concentration in the floodwater, but had little impact on inorganic nitrogen levels. Through screening with random forest analysis and structural equation modelling, it was found that weed density and biomass were predominantly influenced by the reduced light transmittance (54.1% and 77.2%, p ≤ 0.001) resulting from duckweed covering while the decline in dissolved oxygen content partly influenced weed density (18%). In conclusion, this study’s results bring a different perspective, confirming the sunlight-shading effect of duckweed as a critical mechanism significantly inhibiting the germination and growth of weeds. These findings provide a scientific basis for the improved application of ecological weed control methods in paddy fields.
Optimizing Nutrient and Energy Efficiency in a Direct-Seeded Rice Production System: A Northwestern Punjab Case Study
Authors: Kaur Ranjot , Chhina Gurbax Singh , Kaur Mandeep , Bhatt Rajan , Elhindi Khalid M. , Mattar Mohamed A.
Published: March 2024

This study was carried out in Amritsar, Punjab, to find out how efficiently nutrients were used and how much energy was employed in direct-seeded rice (DSR) production. In this study, four levels of nitrogen (0, 40, 50, and 60 kg N ha−1) and three levels of phosphorus (0, 37.5, and 45 kg P2O5 ha−1) were tested. In a rice production system, the energy indices of various inputs and outputs were evaluated through the application of energy equivalency. The nutrient-use efficiencies in rice were assessed using different efficiency indices. The maximum grain yields of 38.9 q ha−1 and 36.9 q ha −1 were recorded at 50 kg N ha−1 and 45 kg P2O5 ha−1, respectively. On the other hand, application of nitrogen at 60 kg N ha−1 and phosphorus at 45 kg P2O5 ha−1 resulted in maximum straw yield of 57.1 q ha−1 and 51.1 q ha−1, respectively. In comparison with the control, application of 60 and 50 kg N ha−1 resulted in 161.9% and 151.0% higher grain yield, respectively. On the other hand, with applications of 45 kg P2O5 ha−1 and 37.5 kg P2O5 ha−1, an increase in the grain yield of 17.3 and 28.6%, respectively, over the control was recorded. Moving further towards nutrient-use efficiencies (NUEs), the highest values of partial factor productivity of nitrogen (PFPN), agronomic efficiency of nitrogen (AEN), partial nutrient balance of nitrogen (PNBN), and recovery efficiency of nitrogen (REN) were 89.1, 50.4, 1.78 and 0.72, respectively, which were obtained at 40 kg N ha−1, after which the values started decreasing steadily. In the case of phosphorus, the partial factor productivity (PFPP) of 88.6 was the maximum at 37.5 kg P2O5 ha−1, but partial nutrient balance (PNBP) of 0.36 and recovery efficiency (REP) of 0.08 were highest at 45 kg P2O5 ha−1. The main results revealed that the farmer field had an excessive amount of non-renewable energy inputs. The experimental field depicted greater energy-usage efficiency (EUE) of 4.5, energy productivity (EP) of 0.14, and energy profitability (EP1) of 3.5. These results were primarily ascribed to a significant drop in energy inputs under direct-seeded rice (DSR). In the case of non-renewable energy inputs, fertilizer made the maximum contribution to energy input (47.9%) in the farmer’s field. We conclude that nutrient-use efficiencies and energy-use efficiency were highest at 50 kg N and 45 kg P2O5 ha−1. This recommendation is beneficial for farmers because lower inputs and higher outputs are the main objective of every farmer.
Apple Growth and Yield in Replant Soils Supplemented by Organic Soil Additives
Authors: Djalali Farahani-Kofoet Roxana , Schneider Daniel , Feller Carmen
Published: March 2024

Repeated apple cultivation in the same area leads to apple replant disease (ARD), which can probably be reduced by the use of organic supplements and selected rootstock/variety combinations. Soils at two conventionally and one organically farmed site in north-eastern Germany were tested for ARD in pot trials. In subsequent field trials, the effects of champost, microbially carbonised compost, and coniferous wood shavings piled up like a dam (‘Müncheberger Damm’ (M)-dam) and of rootstock/variety combinations were tested. On the organic site, only leonardite and champost were tested. The pot trials indicated for all sites that the soil is affected by ARD. After five years, the growth increase in trunks in the M-dam was 20–40% higher than in controls and other treatments, depending on the site. On one site, the yield over four years was a 15.7% increase for M-dam and also for champost compared to controls, on the other site, it was 11.7% and 3.0%, respectively. The M.9 rootstock with the Gala variety had a higher, but insignificant, yield compared to G.11/Gala by 6.7 or 2.6%, depending on the site. No difference in trunk growth or yield with Topaz was observed at the organic farmed site. Further research on M-dam and champost is supported, as both are promising in terms of yield.
Improving Water Productivity Using Subsurface Drip Irrigation in the Southwest Monsoon Area in Yunnan Province of China
Authors: Wan Long , Jian Yi , Zhang Mei , Tong Jing , Rebi Ansa , Zhou JinXing
Published: March 2024

Due to the influence of the Asian southwest monsoon, seasonal drought is serious and water resources are scarce in the Yunnan province of Southwest China. More effective water-saving irrigation methods should be developed to solve the problem of water scarcity in the dry season. In this study, a subsurface drip irrigation method was used to improve the water productivity of tomato cultivation. Deficit irrigation was conducted. We controlled the lower limit of soil moisture at three different levels (55~65%, 65~75%, and 75~85% of the field capacity). The results indicated that the subsurface drip irrigation treatment significantly increased tomato height in the later stage of tomato growth. Due to the buried pipes, the root/shoot ratio was 8~18% higher for subsurface drip irrigation than for surface drip irrigation methods. Though the yields using subsurface drip irrigation methods were slightly lower than those obtained using surface drip irrigation methods, the tomato quality and water productivity improved significantly. The subsurface drip irrigation methods improved the water productivity by 8.5~21.8% at different soil moisture levels and improved the chlorophyll content by 9.1~17.3%. The VC, soluble sugar, soluble solids, and the ratio of sugar to acid increased by 6.5~15.2%, 7.3~21.6%, 4.1~6.6%, and 3.2~20.8%. This study also indicated that by optimizing the irrigation methods and patterns, water productivity and fruit quality could be improved by more than 50%. This research will be helpful for guiding irrigation during the drought season in the southwest monsoon area in Asia.
Effects of Different Ecological Restoration Pattern on Soil Organic Nitrogen Components in Alpine Sandy Land
Authors: Jiang Haodong , Yang Nairui , Qian Hongyu , Chen Gang , Wang Wei , Lu Jiankai , Li Yaocen , Hu Yufu
Published: March 2024

Ecological restoration can improve soil fertility and have a significant impact on the soil nitrogen cycle. Nitrogen (N) is an essential nutrient element for plant growth and development, and also an important factor limiting soil productivity. As an important part of soil nitrogen, the composition and proportion of soil organic nitrogen components can directly or indirectly affect the difficulty of soil organic nitrogen mineralization and nitrogen availability, and then affect soil fertility. However, the current studies on soil nitrogen under ecological restoration mainly focus on nitrogen accumulation and nitrogen mineralization, while there are relatively few studies on changes in soil organic nitrogen components, especially in alpine regions. Therefore, in this study, three restoration pattern of mixed forage (MG), single shrub (SA) and shrub combination (SG) that have been restored continuously for 15 years in northwest Sichuan, China, were taken as the research object, and natural sandy land (CK) without manual intervention was taken as the control. Through field sampling and laboratory analysis, the characteristics of the soil nitrogen content and its proportion to soil total nitrogen (TN) under ecological restoration in alpine sandy land in northwest Sichuan, China, were investigated, and the correlation between the nitrogen content and soil physicochemical properties was analyzed. The results showed that the three ecological restoration patterns significantly increased the contents of acylated ammonium nitrogen (AMMN), acid-lyzed amino sugar nitrogen (ASN), acid-lyzed amino acid nitrogen (AAN), acid-lyzed unknown nitrogen (HUN), acid-lyzed total nitrogen (AHN) and non-acid-lyzed nitrogen (NHN) in soil, and the change trend was consistent with that of soil TN. Ecological restoration improved soil nitrogen mineralization and storage capacity by increasing the proportion of AAN, HUN and NHN to soil TN, and the effect was most obvious in the MG pattern 20–40 cm and SG pattern 40–60 cm soil layers. In general, except ASN, the soil nitrogen content was positively correlated with the soil TN, soil water content (SWC) and soil organic carbon (SOC), and negatively correlated with the soil bulk density (BD) and pH. The results of this study will help us to understand the supply capacity of soil nitrogen under ecological restoration and provide a scientific basis for the selection of an ecological restoration mode and the improvement of the restoration effect and efficiency in alpine sandy land.
Outcome of Percutaneous Endoscopic Lumbar Discectomy in Relation to the Surgeon’s Experience: Propensity Score Matching
Authors: Son Seong , Oh Michael Y. , Park Han Byeol , Lopez Alexander M.
Published: March 2024

Percutaneous endoscopic lumbar discectomy (PELD) presents a challenging learning curve, and the correlation between surgeon experience and clinical outcomes remains contentious. This retrospective study aimed to compare the outcomes of PELD performed by a single surgeon at beginner and experienced stages. Propensity score matching selected 150 patients (75 per group) with a minimum 3-year follow-up. Clinical and radiological outcomes, perioperative complications, and adverse events were assessed. Baseline characteristics, pain improvement, patient satisfaction, and radiological outcomes did not differ between the groups. However, operation time was longer in the beginner group than in the experienced group (57.5 min [IQR, 50.0–70.0] versus 50.0 min [IQR, 45.0–55.0], p < 0.001). The beginner group had higher perioperative complication rates (eight patients [10.7%] versus one patient [1.3%], with a hazard ratio of 8.836 [95% CI, 1.077–72.514], p = 0.034) and lower 3-year survival without adverse events (19 patients [25.3%] in the beginner group and 10 patients [13.3%] in the experienced group, p = 0.045). Our findings indicate that the clinical outcomes were more favorable in patients operated on at the experienced stage compared to those treated at the beginner stage.
Flow and Heat Transfer of CoFe2O4-Blood Due to a Rotating Stretchable Cylinder under the Influence of a Magnetic Field
Authors: Alam Jahangir , Murtaza Ghulam , Tzirtzilakis Efstratios E. , Sun Shuyu , Ferdows Mohammad
Published: March 2024

The flow and heat transfer of a steady, viscous biomagnetic fluid containing magnetic particles caused by the swirling and stretching motion of a three-dimensional cylinder has been investigated numerically in this study. Because fluid and particle rotation are different, a magnetic field is applied in both radial and tangential directions to counteract the effects of rotational viscosity in the flow domain. Partial differential equations are used to represent the governing three-dimensional modeled equations. With the aid of customary similarity transformations, this system of partial differential equations is transformed into a set of ordinary differential equations. They are then numerically resolved utilizing a common finite differences technique that includes iterative processing and the manipulation of tridiagonal matrices. Graphs are used to depict the physical effects of imperative parameters on the swirling velocity, temperature distributions, skin friction coefficient, and the rate of heat transfer. For higher values of the ferromagnetic interaction parameter, it is discovered that the axial velocity increases, whereas temperature and tangential velocity drop. With rising levels of the ferromagnetic interaction parameter, the size of the axial skin friction coefficient and the rate of heat transfer are both accelerated. In some limited circumstances, a comparison with previously published work is also handled and found to be acceptably accurate.
Engineering Precise Interconnected Porosity in β-Tricalcium Phosphate (β-TCP) Matrices by Means of Top–Down Digital Light Processing
Authors: Wojcik Thomas , Chai Feng , Hornez Vincent , Raoul Gwenael , Hornez Jean-Christophe
Published: March 2024

This study evaluated the biocompatibility and accuracy of 3D-printed β-tricalcium phosphate (β-TCP) pure ceramic scaffolds. A specific shaping process associating a digital light processing (DLP) 3D printer and a heat treatment was developed to produce pure β-TCP scaffolds leaving no polymer binder residue. The β-TCP was characterised using X-ray diffraction, infrared spectroscopy and the detection of pollutants. The open porosity of produced matrices and their resorption were studied by hydrostatic weighing and calcium release measures. The biocompatibility of the printed matrices was evaluated by mean of osteoblast cultures. Finally, macroporous cubic matrices were produced. They were scanned using a micro-Computed Tomography scanner (micro-CT scan) and compared to their numeric models. The results demonstrated that DLP 3D printing with heat treatment produces pure β-TCP matrices with enhanced biocompatibility. They also demonstrated the printing accuracy of our technique, associating top-down DLP with the sintering of green parts. Thus, this production process is promising and will enable us to explore complex phosphocalcic matrices with a special focus on the development of a functional vascular network.
Determinants of Carotid Wall Echolucency in a Cohort of European High Cardiovascular Risk Subjects: A Cross-Sectional Analysis of IMPROVE Baseline Data
Authors: Frigerio Beatrice , Coggi Daniela , Bonomi Alice , Amato Mauro , Capra Nicolò , Colombo Gualtiero I. , Sansaro Daniela , Ravani Alessio , Savonen Kai , Giral Philippe , Gallo Antonio , Pirro Matteo , Gigante Bruna , Eriksson Per , Strawbridge Rona J. , Mulder Douwe J. , Tremoli Elena , Veglia Fabrizio , Baldassarre Damiano
Published: March 2024

Echolucency, a measure of plaque instability associated with increased cardiovascular risk, can be assessed in both the carotid plaque and the plaque-free common carotid intima–media (IM) complex as a gray-scale median (plaque-GSM and IM-GSM, respectively). The impact of specific vascular risk factors on these two phenotypes remains uncertain, including the nature and extent of their influence. This study aims to seek the determinants of plaque-GSM and IM-GSM. Plaque-GSM and IM-GSM were measured in subjects from the IMPROVE study cohort (aged 54–79, 46% men) recruited in five European countries. Plaque-GSM was measured in subjects who had at least one IMTmax ≥ 1.5 mm (n = 2138), whereas IM-GSM was measured in all subjects included in the study (n = 3188). Multiple regression with internal cross-validation was used to find independent predictors of plaque-GSM and IM-GSM. Plaque-GSM determinants were plaque-size (IMTmax), and diastolic blood pressure. IM-GSM determinants were the thickness of plaque-free common carotid intima–media complex (PF CC-IMTmean), height, systolic blood pressure, waist/hip ratio, treatment with fibrates, mean corpuscular volume, treatment with alpha-2 inhibitors (sartans), educational level, and creatinine. Latitude, and pack-yearscode were determinants of both plaque-GSM and IM-GSM. The overall models explain 12.0% of plaque-GSM variability and 19.7% of IM-GSM variability. A significant correlation (r = 0.51) was found between plaque-GSM and IM-GSM. Our results indicate that IM-GSM is a weighty risk marker alternative to plaque-GSM, offering the advantage of being readily measurable in all subjects, including those in the early phases of atherosclerosis where plaque occurrence is relatively infrequent.
Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer
Authors: Wurschi Georg W. , Rühle Alexander , Domschikowski Justus , Trommer Maike , Ferdinandus Simone , Becker Jan-Niklas , Boeke Simon , Sonnhoff Mathias , Fink Christoph A. , Käsmann Lukas , Schneider Melanie , Bockelmann Elodie , Krug David , Nicolay Nils H. , Fabian Alexander , Pietschmann Klaus
Published: March 2024

Total neoadjuvant therapy (TNT) is an evolving treatment schedule for locally advanced rectal cancer (LARC), allowing for organ preservation in a relevant number of patients in the case of complete response. Patients who undergo this so-called “watch and wait” approach are likely to benefit regarding their quality of life (QoL), especially if definitive ostomy could be avoided. In this work, we performed the first cost-effectiveness analysis from the patient perspective to compare costs for TNT with radical resection after neoadjuvant chemoradiation (CRT) in the German health care system. Individual costs for patients insured with a statutory health insurance were calculated with a Markov microsimulation. A subgroup analysis from the prospective “FinTox” trial was used to calibrate the model’s parameters. We found that TNT was less expensive (−1540 EUR) and simultaneously resulted in a better QoL (+0.64 QALYs) during treatment and 5-year follow-up. The average cost for patients under TNT was 4711 EUR per year, which was equivalent to 3.2% of the net household income. CRT followed by resection resulted in higher overall costs for ostomy care, medication and greater loss of earnings. Overall, TNT appeared to be more efficacious and cost-effective from a patient’s point of view in the German health care system.
An Automated Imaging-Based Screen for Genetic Modulators of ER Organisation in Cultured Human Cells
Authors: Garcia-Pardo M. Elena , Simpson Jeremy C. , O’Sullivan Niamh C.
Published: March 2024

Hereditary spastic paraplegias (HSPs) are a heterogeneous group of mono-genetic inherited neurological disorders, whose primary manifestation is the disruption of the pyramidal system, observed as a progressive impaired gait and leg spasticity in patients. Despite the large list of genes linked to this group, which exceeds 80 loci, the number of cellular functions which the gene products engage is relatively limited, among which endoplasmic reticulum (ER) morphogenesis appears central. Mutations in genes encoding ER-shaping proteins are the most common cause of HSP, highlighting the importance of correct ER organisation for long motor neuron survival. However, a major bottleneck in the study of ER morphology is the current lack of quantitative methods, with most studies to date reporting, instead, on qualitative changes. Here, we describe and apply a quantitative image-based screen to identify genetic modifiers of ER organisation using a mammalian cell culture system. An analysis reveals significant quantitative changes in tubular ER and dense sheet ER organisation caused by the siRNA-mediated knockdown of HSP-causing genes ATL1 and RTN2. This screen constitutes the first attempt to examine ER distribution in cells in an automated and high-content manner and to detect genes which impact ER organisation.
Dependence of Renal Uptake on Kidney Function in [68Ga]Ga-PSMA-11 PET/CT Imaging
Authors: Gühne Falk , Schilder Till , Seifert Philipp , Kühnel Christian , Freesmeyer Martin
Published: March 2024

(1) Background: PSMA ligand PET/CT is increasingly important for diagnostics of prostate cancer and other tumor diseases. In particular, the radiopharmaceutical [68Ga]Ga-PSMA-11 is widely used. Besides its tumor-specific binding, the uptake within the kidneys is dominant and seems to visualize the renal cortex specifically. Kidney diseases may alter the uptake of radiopharmaceuticals. Therefore, the correlation between renal uptake in PET/CT imaging and renal function should be investigated. (2) Methods: A group of 103 male patients were retrospectively evaluated for eGFR according to the CKD-EPI equation, tracer uptake intensity (SUVmax, SUVpeak, SUVmean), the molecular volume of the renal cortex, morphological kidney size, and total renal uptake. Manual and three different computer-assisted contouring methods (thresholds at 50% of SUVmax, 30% of SUVmax, and absolute SUV of 20) were used for measurements. Correlations between parameters were calculated using linear regression models. (3) Results: Renal SUVmax, SUVpeak, and SUVmean do not correlate with eGFR for manual or computer-assisted measurements. In contrast, molecular cortex volume shows a moderate correlation with eGFR (R2 = 0.231, p < 0.001), superior to morphological kidney size. A contouring threshold of 30% of SUVmax outperformed the other settings for renal cortex volume and total renal uptake. (4) Conclusions: Renal uptake of [68Ga]Ga-PSMA-11 cannot predict eGFR, but the functional renal cortex can be quantified by PET/CT imaging.
Sexual Functioning and Impact on Quality of Life in Patients with Early-Onset Colorectal Cancer: A Systematic Review
Authors: Feier Catalin Vladut Ionut , Paunescu Ionut Andrei , Faur Alaviana Monique , Cozma Gabriel Veniamin , Blidari Andiana Roxana , Muntean Calin
Published: March 2024

This systematic review investigates the intersection of early-onset colorectal cancer (EOCRC), sexual functioning, and associated quality of life (QoL), aiming to understand the comprehensive impact of EOCRC on these critical dimensions. Through an extensive search across PubMed, Scopus, and Embase up until November 2023, this study synthesized evidence from the literature while adhering to PRISMA guidelines. The studies included EOCRC patients under 50 years, which examined sexual functioning and QoL using validated instruments, and were published in English. After a rigorous screening process, five relevant studies were identified from an initial pool of 2184 articles. This review includes data from five studies involving 2031 EOCRC patients. The key findings revealed a high prevalence of sexual dysfunction, with up to 50% of men experiencing impotence and 58% reporting sexual dysfunction, alongside 36% of women in some studies. Pain was described by 12% to 31% of patients. Anxiety and depression were notably prevalent, affecting up to 69% of participants. EOCRC profoundly impacts sexual functioning and QoL, with a significant prevalence of sexual dysfunction and psychological distress among affected individuals. These findings suggest the need for oncological management strategies that include not only medical treatment but also psychological support and sexual health interventions. This systematic review emphasizes the importance of holistic patient care approaches, advocating for further research and clinical attention to address the complex needs of younger EOCRC patients.
Dark Matter and Mirror World
Authors: Mohapatra Rabindra N.
Published: March 2024

Overwhelming astronomical evidence for dark matter and absence of any laboratory evidence for it despite many dedicated searches have fueled speculation that dark matter may reside in a parallel universe interacting with the familiar universe only via gravitational interactions as well as possibly via some ultra-weak forces. In this scenario, we postulate that the visible universe co-exists with a mirror world consisting of an identical duplicate of forces and matter of our world, obeying a mirror symmetry. This picture, motivated by particle physics considerations, not only provides a natural candidate for dark matter but also has the potential to explain the matter dark matter coincidence problem, i.e., why the dark matter content of the universe is only a few times the visible matter content. One requirement for mirror models is that the mirror world must be colder than our world to maintain the success of big bang nucleosynthesis. After a review of the basic features of the model, we present several new results: first is that the consistency between the coldness of the mirror world and the explanation of the matter dark matter coincidence implies an upper bound on the inflation reheat temperature of the universe to be around 106.5 GeV. We also argue that the coldness implies the mirror world consists mainly of mirror Helium and very little mirror hydrogen, which is the exact opposite of what we see in the visible world.
The Perceptions and Attitudes of Peers towards Students with Special Needs as Reflected by Their Drawings and the Social Acceptance Scale
Authors: Dağlı Gökbulut Özlem , Gökbulut Burak , Yeniasır Mustafa
Published: March 2024

Inclusive education processes, in which teachers, students and parents play an active role, serve an extremely important function in the adaptation of individuals with special needs to academic and social life. These educational processes serve the purpose of including individuals with special needs in the same learning environments with their peers. In this way, these individuals not only improve their skills more quickly, but also improve their social abilities through interaction with their peers, increasing their likelihood of being accepted by the society at large. It is critical for their peers to be aware of the needs of children with special needs and to approach them with this awareness so that inclusive education proves successful and individuals with special needs can have a better future. In this study, the perceptions of peers towards individuals with special needs were determined through their drawings, and their attitudes towards these individuals were revealed by means of the applied attitude scale. The 42 drawings obtained were examined and a total of five themes were generated, namely: help and friendship, success, exclusion, physical challenges, and hospital-rehabilitation center settings. Based on the pictures drawn by children who are developing typically and their answers on the scale, it can be concluded that they generally have a positive attitude towards their peers with special needs and they mostly do not see them as distinct from their other friends.
Challenges for Pedagogical Effectiveness in an Ever-Changing Education Landscape: Conceptualisation of Pedagogical Mobility and Flexibility as a Context-Consciousness
Authors: du Plessis Anna Elizabeth , Küng Elize , du Plessis Elize
Published: March 2024

The challenges to maintaining pedagogical effectiveness in an ever-changing education landscape not only turn focus on the professional development of teachers and their teaching practices but also emphasise the preparation of pre-service teachers and their skill development to practice pedagogical flexibility and mobility while focusing on context-consciousness [...]
Optimization of Inlet Hydrogen Temperature during the Fast-Filling Process Based on a Back Propagation Neural Network Model
Authors: Wang Xu , Hui Chun , Liu Dongwei , Deng Shanshan , Sui Pang-Chieh
Published: March 2024

A reasonable inflating strategy must be developed for filling an onboard hydrogen storage tank with hydrogen gas. The inflow hydrogen temperature has always been a constant value in filling cases. However, in our opinion, the optimal inflow hydrogen temperature is not supposed to be a fixed value but a value that constantly changes and adjusts with filling time, i.e., the inflow hydrogen temperature is a function of the filling time. How to determine this functional relationship is a critical problem to be addressed. Herein, an approach is introduced. A dual-zone model is presented to research the thermal effect during the process of charging hydrogen storage tanks. Based on the numerical results of the dual-zone model, the charging process was divided into three stages, allowing us to obtain data for 1331 filling cases. Then, a back propagation (BP) neural network model was built to analyze the data, and the implicit relationship between the inflow hydrogen temperatures and maximum hydrogen temperature pressure could be deduced. With this implicit relationship, the critical values of the inflow hydrogen temperatures can be obtained from the critical situation. Suppose the inflow hydrogen temperatures in a practical case are higher than the critical values. In that case, the highest hydrogen temperature in the tank will exceed the limited safety value of 358 K. In contrast, if the inflow hydrogen temperatures are lower than the critical values, then more energy will be needed to precool the inlet hydrogen temperature. Thus, theoretically, the critical inflow hydrogen temperatures should be at their optimal values.
Control and Intelligent Optimization of a Photovoltaic (PV) Inverter System: A Review
Authors: Zhang Qianjin , Zhai Zhaorong , Mao Mingxuan , Wang Shijing , Sun Siwei , Mei Dikui , Hu Qi
Published: March 2024

PV power generation is developing fast in both centralized and distributed forms under the background of constructing a new power system with high penetration of renewable sources. However, the control performance and stability of the PV system is seriously affected by the interaction between PV internal control loops and the external power grid. The impact of the PV system on the reliability, stability, and power quality of power systems has restricted them to further participate in power supplies with a large capacity. Traditional control methods have become ineffective at dealing with these problems as the PV system becomes increasingly complex and nonlinear. Intelligent control as a more advanced technology has been integrated into the PV system to improve system control performance and stability. However, intelligent control for the PV system is still in the early stages due to the extensive calculation and intricate implementation of intelligent algorithms. Further investigations should be carried out to effectively combine intelligent control with the PV system to constitute an intelligent PV power system with multiple functions, high stability, and high-performance. This paper provides a systematic classification and detailed introduction of various intelligent optimization methods in a PV inverter system based on the traditional structure and typical control. The future trends and research topics are given to provide a reference for the intelligent optimization control in the PV system.
Optical Wireless Power Transmission under Deep Seawater Using GaInP Solar Cells
Authors: Takahashi Ryusei , Hayashi Shunki , Watanabe Kosuke , Jikun Li , Iida Takehiro , Suzuki Junichi , Uchida Shiro
Published: March 2024

Optical wireless power transmission (OWPT) attracts attention because it enables wireless power transfer over longer distances than current wireless power transfer methods, irradiating laser light to a light-receiving element. In this study, an OWPT system was investigated under water and deep seawater using visible lasers with low optical absorption loss in water. Three laser beams (450 nm, 532 nm, and 635 nm) were transmitted through 30 cm, 60 cm, and 90 cm long tanks filled with tap water and deep seawater and were irradiated to 1.0 × 1.0 cm2 GaInP solar cells. The light reaching rate (ηop) of laser light and the system efficiency (ηsys) of the system (excluding the laser efficiency) were investigated. GaInP solar cells showed photo-electric conversion efficiencies of 30.6%, 40.3%, and 39.3% for 450 nm, 532 nm, and 635 nm irradiations, respectively. As a result, a 532 nm laser through a 90 cm water tank in tap water showed a 78.4% ηop and a 30.8% ηsys. Under deep seawater, a 532 nm laser through a 90 cm tank exhibited a 58.3% ηop and a 23.5% ηsys. A 532 nm green laser showed a higher efficiency than the other 450 nm and 635 nm lasers in this underwater system using GaInP solar cells.
Oil-Water Two-Phase Flow with Three Different Crude Oils: Flow Structure, Droplet Size and Viscosity
Authors: Lv Yuling , Chen Shujiong , Lv Guobin , He Limin
Published: March 2024

The study focuses on the flow patterns and pressure drop characteristics of three crude oils and water in a horizontal pipe. The experimental results showed that the transformation boundary of the flow pattern and phase inversion water fraction were related to the flow parameters. Comparing the three oils, it was found that the viscosity and composition of the oil also significantly influence the flow performance, which can be explained by the adsorption properties of the asphaltenes at the oil-water interface. In particular, the droplet size in water-in-oil dispersion flow was observed and measured. It showed that the water droplet size decreased with the increase of oil viscosity, the decrease of water content, the drop of temperature, and the growth of mixing velocity, probably due to higher shear stress and lower frequency of collision and coalescence between droplets. The apparent viscosity of water-in-oil emulsions was calculated by the rheological model, and the qualitative relation between flow parameters and interfacial area concentration on apparent viscosity was obtained. Taking the influence of interfacial area concentration into consideration, a simple and accurate viscosity model was established based on dimensional analysis, which is of great significance for process design in gathering and transportation systems.
Evaluation of Technological Configurations of Residential Energy Systems Considering Bidirectional Power Supply by Vehicles in Japan
Authors: Osawa Jun
Published: March 2024

To reduce CO2 emissions in the residential and transportation sectors, distributed energy technologies, such as photovoltaic power generation (PV), stationary storage batteries (SBs), battery electric vehicles (BEVs), and vehicle-to-home (V2H) systems, are expected to be introduced. The objective of this study was to analyze the impact of the installed capacity of PV and SB, the type of vehicle, and their combination on the economic and environmental performance of the total energy consumption of residences and vehicles. Thus, this study developed a model to optimize the technological configuration of residential energy systems, including various vehicle types and driving patterns. The simulation results showed that it is more economically and environmentally efficient to install a BEV and a V2H system in households with longer parking times at the residence and to install an SB in addition to these technologies in households with shorter parking times at the residence. Furthermore, comparing a gasoline vehicle and an SB, the most economical combination, with a BEV and a V2H system and with a BEV, a V2H system, and an SB, estimated the carbon tax rate necessary for cost equivalence. The result indicated that the carbon tax rate needs to be increased from its current level.
Design Procedure of Cascaded Multilevel Inverter for High-Power Amplifier in SONAR System
Authors: Jang Jejin , Choi Jaehyuk , Lee Donghun , Mok Hyungsoo
Published: March 2024

In recent years, there has been a trend toward expanding the operating frequency range and increasing the output power of Sound Navigation and Ranging (SONAR) systems to enhance their acoustic detection capabilities. However, due to this increase in operational power, the electrical capacity of amplifiers for SONAR system operation also increases, necessitating High-Power Amplifiers. When configured with a single amplifier, as in conventional methods, the volume of amplifiers increases due to volumetric increases in heat dissipation, components, and windings. These issues are detrimental to SONAR amplifier installation, mobility, maintenance, and equipment lifespan due to stress on individual components. Additionally, amplifiers for SONAR systems are comprised of power conversion devices, transformers for LC filters and matching, necessitating consideration of LC filters and matching transformers for enhancing voltage quality and efficiency to improve amplifier performance transmitted to SONAR transducers. However, previous research has focused on single-amplifier design methods, neglecting such considerations. Therefore, this paper proposes a design technique that overcomes the drawbacks of using the conventional design method by configuring multiple H-bridge inverters in a cascade format and utilizes one of the optimization algorithms, Particle Swarm Optimization (PSO), to derive amplifier design techniques that optimize component parameters for enhancing high-capacity amplifier performance. Subsequently, theoretical analysis, simulations, and experimental results comparing the proposed high-power amplifier design method with conventional single-amplifier design methods demonstrate similar error rates in operational frequency bands.