bluuebunny/crossref_metadata_2025 huggingface dataset:
Political Growth Collapses
Authors: Rodriguez Francisco , Imam Patrick A
Published: July 2022

We argue that economic collapses can result from the adoption by political actors of strategies that generate severe negative economic externalities for society. We establish the conditions for political conflict to become economically destructive and develop a diagnostics toolkit to identify when income declines are consequence of the breakdown of conflict-management arrangements. When political conflict drives a collapse in growth, we expect the onset of the contraction to coincide with the intensification of political conflict, authority to be truly contested, politically advantageous strategies to generate negative externalities, economic collapse to be driven by productivity losses, short-term biases in policies to increase with contestation of power, and the policy framework to improve once political conflict recedes. We argue that all these conditions were satisfied in two of the largest peacetime collapses in modern history: Venezuela (2012–2020) and Zimbabwe (1997–2008).JEL Codes: O11, D72, D74.
Interchangeability of transthoracic and transesophageal echocardiographic right heart measurements in the perioperative setting and correlation with hemodynamic parameters
Authors: Assanangkornchai Nawaporn , Villeneuve Valerie , McDonald Sarah , Magder Sheldon , Tim Dominique Shum , Buithieu Jean , Hatzakorzian Roupen
Published: July 2022

Purpose Reduction of right ventricular (RV) function after cardiac surgery has been shown to impact outcomes. Conventional indices for right ventricular dysfunction are validated using transthoracic echocardiogram (TTE) which has limited use compared to transesophageal echocardiogram (TEE) in the perioperative settings. The aim of this study was to assess the agreement of RV systolic function assessment with TEE compared to TTE and assess the association of echocardiographic parameter with hemodynamic indices of RV dysfunction. Method This was a single center prospective observational study in an academic institution. Fifty adult patients undergoing elective cardiac surgery were included. TTE, TEE and stroke volume measurements pre-cardiopulmonary bypass (CPB) and post-CPB were performed. The variables of interest were anatomical M-mode tricuspid annular plane systolic excursion (AMM-TAPSE), fractional area change (FAC), tricuspid annular velocity (S’) and myocardial performance index (MPI). Results FAC and AMM-TAPSE measured at the mid-esophageal 4 chamber view had substantial agreement with the TTE acquired parameters (Lin’s concordance correlation coefficient (CCC) = 0.76, 95%CI 0.59-0.86 and CCC = 0.85, 95%CI 0.76-0.91). S’ was significantly underestimated by TEE (CCC = 0.07, 95%CI -0.04-0.19) and MPI showed moderate agreement (CCC = 0.45 95%CI 0.19-0.65). Despite the significant changes in echocardiographic parameters, there were no corresponding changes in stroke volume (SV) or pulmonary artery pulsatility index at the post-CPB period. Conclusions TEE acquired FAC and AMM-TAPSE had substantial agreement with pre-operative TTE values and no significant differences between the pre-CPB and post-CPB period. Systolic RV echocardiographic parameters decreased post-CPB but this was not accompanied by significant hemodynamic changes.
Collaborative Task Offloading and Resource Allocation with Hybrid Energy Supply for UAV-Assisted Multi-Clouds
Authors: Zhou Yu , Ge Hui , Ma Bowen , Zhang Shuhang , Huang Jiwei
Published: July 2022

Cloud computing has emerged as a promising paradigm for meeting the growing resource demands of Internet of Things (IoT) devices. Meanwhile, with the popularity of mobile aerial base stations, Unmanned Aerial Vehicle (UAV) assisted cloud computing is essential for providing diversified service at areas without available infrastructure. However, it is difficult to meet the requirements of a number of IoT devices which distribute a large area through one single UAV cloud server, and thus multi-clouds have been applied in large-scale IoT environments. Due to the limited battery capacity of UAV, hybrid energy supply has been considered as an effective approach. How to allocate the computing resources and offload the tasks to the UAV-assisted clouds is a challenging task. In this paper, we study the trade-off between the energy consumption and system performance in a UAV-assisted multi-clouds system. Considering the transmission and execution cost, a dynamic optimization problem with the objective of minimizing the power consumption of UAVs with the constraint of queue stability is formulated, which is further decomposed into three sub-problems using stochastic optimization techniques. A collaborative task offloading and resources allocation algorithm (CTORAA) based on artificial intelligent technique is proposed to jointly determine task offloading and energy harvesting. We provide corresponding mathematical analysis showing that CTORAA can reach the arbitrary profit-stability trade-off. Finally, we conduct simulation experiments to validate the efficacy of our algorithm.
Autocatalytic reaction cycles for non-enzymatic synthesis of life-sustaining sugars in neutral media
Authors: Tabata Hiro , Chikatani Genta , Nishijima Hiroaki , Harada Takashi , Miyake Rika , Kato Souichiro , Igarashi Kensuke , Mukouyama Yoshiharu , Shirai Soichi , Waki Minoru , Hase Yoko , Nakanishi Shuji
Published: July 2022

Biological assimilation of CO2 to produce sugars occurs in metabolic cycles with an autocatalytic nature, such as the Calvin cycle and reverse citric acid cycle. The formose reaction, in which sugars are non-enzymatically synthesized from formaldehyde in alkaline solutions, involves such an autocatalytic cycle and has attracted much interest from the viewpoint of the abiotic chemical synthesis of sugars. However, many side reactions are indiscriminately accelerated by hydroxide ions in an alkaline aqueous solution, which results in a very low selectivity of sugar formation. Here we report non-enzymatic sugar synthesis in a neutral aqueous solution using mono-oxometalate as a catalyst to form an autocatalytic cycle. The construction of an autocatalytic reaction system in a neutral aqueous solution significantly improved the selectivity of sugar formation. It was also demonstrated that abiotically synthesized sugars could sustain the growth of microbial cells.
SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells
Authors: Tang Ling , Peng Ling , Liu Huai , Xiao Tengfei , Gu Wangning , Yang Hongmin , Wang Hui , chen pan
Published: July 2022

Background: Nasopharyngeal carcinoma (NPC) is one of the aggressive malignant tumors with high mortality, and the proliferation of myeloid-derived suppressor cells (MDSCs) could promote the metastasis of NPC through inhibiting the function of T cells. Meanwhile, SPLUNC1 was known to inhibit the malignant behavior of NPC cells, while the detailed function of SPLUNC1 in LPS-modified immune microenvironment of NPC remains unclear.Methods: To assess the impact of SPLUNC1 in immune microenvironment during the progression of NPC, NPC cells were exposed to LPS and then co-cultured with MDSCs for 48 h. RT-qPCR and western blot were performed to evaluate the mRNA and protein levels, respectively. The levels of cytokines were tested by ELISA. Meanwhile, the expression of CD33+ was tested by flow cytometry. Results: The expressions of CXCL-2 and CXCR-2 in NPC cells were higher, compared with those in NP69 cells. In contrast, SPLUNC1 level in NPC cells was much lower than that in NP69 cells. SPLUNC1 level was negatively correlated with CXCL-2 and CXCR-2. Overexpression of SPLUNC1 reversed LPS-induced inflammatory responses and proliferation in NPC cells. In addition, SPLUNC1 upregulation could reverse LPS-induced proliferation of MDSCs in tumor microenvironment. Meanwhile, SPLUNC1 overexpression could regulate CXCL-2/CXCR-2 axis. Conclusion: SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of MDSCs. Thus, our study might provide a theoretical basis for discovering new strategies against NPC.
The analytical solution to the migration of an epithelial monolayer with a circular spreading front and its implications in gap closure process
Authors: Zhao Tiankai , Yuan Hongyan
Published: July 2022

Coordinated behaviors of epithelial cells are widely observed in tissue development such as re-epithelialization, tumor growth, and morphogenesis. In these processes, cells either migrate collectively or organize themselves into specific structures to serve certain purposes. In this work, we study the spreading epithelial monolayer whose migrating front encloses a circular gap in the monolayer center. Such kind of tissue is usually used to mimic wound healing process in-Virto. We model the epithelial sheet as a layer of active viscous polar fluid. With an axisymmetric assumption, the model can be analytically solved under two special conditions, suggesting two possible spreading modes for the epithelial monolayer. Based on these two sets of analytical solutions, we assess the velocity of the spreading front affected by the gap size, the active intercellular contractility, and the purse-string contraction acting on the spreading edge. It is found that there exist several critical values in the model parameters for the initiation of the gap closure process, and the purse-string contraction plays a vital role in governing the gap closure kinetics. Finally, the instability of the morphology of the spreading front has been studied. Numerical calculations show how the perturbated velocities and the growth rates vary with respect to different model parameters.
Serum MPO-DNA complex is a useful biomarker for predicting target achievement in rheumatoid arthritis
Authors: li Borui , Yang Xinlei , Zhao Juan , Li Guangtao , Zhang Zhuoli
Published: July 2022

Objective: NETosis contributes to the pathogenesis of rheumatoid arthritis (RA), but few studies foused on its clinical values. Therefore, we explored the correlation of serum MPO-DNA complex with RA disease activity, and its ability to predict the therapeutic response. Methods: RA patients were those enrolled for the inducntion stage of the ESCoRT study. All these active RA patients were treated with methotraxate plus TNF inhibitor for 12 weeks and prospectively evaluated every 4 weeks. Serum concentration of MPO-DNA complex was detected by modified enzyme-linked immunosorbent assay. Association of MPO-DNA complex level with disease activity, and the value of MPO-DNA complex in predicting target achievement were analyzed.Results: 86 RA patients were included in the study with the mean age of 55.1 years. At enrollment, 54 (62.8%) patients were with high disease activity (HDA) and 32 (37.2%) with moderate disease activity (MDA). The level of serum MPO-DNA was higher in patients with HDA than that in those with MDA (1.10±0.32 vs. 0.86±0.29, p=0.001). After 4 weeks of treatment, the level of MPO-DNA complex of 86 patients was significantly decreased compared to baseline (0.65±0.25 vs. 1.01±0.32, p<0.001). Change of MPO-DNA complex at week 4 from baseline was postively correlated with the corresponding changes of disease activity score based on 28-joint-count (DAS28), simplied disease activity index (SDAI) and clinical disease activity index (CDAI) (r=0.270-0.495, p<0.05). Receiver operating characteristic (ROC) analysis revealed that the changes of serum MPO-DNA at week 4 from baseline was capable of predicting the achievement of low disease activity (LDA) and remission at week 12, with areas under curve of 0.68 and 0.67 respectively (Defined by DAS28-ESR, all p-values < 0.05). Conclusions: Serum MPO-DNA level was corrrelated with RA disease activity. The change of MPO-DNA at week 4 from baseline was predictive of target achievement at week 12. Serum MPO-DNA may serve as a biomarker in RA treat-to-target strategies.
Expression of radish defensin (RsAFP2) gene in chickpea (Cicer arietinum L.) confers resistance to Fusarium wilt disease
Authors: Sadhu SumanKalyan , Jogam Phanikanth , Gande Kranthikumar , Marapaka Vasudha , Penna Suprasanna , Peddaboina Venkataiah
Published: July 2022

Chickpea (Cicer arietinum L.) is a major nutritional source cultivated worldwide. Chickpea is vulnerable to several abiotic and biotic stresses, including different types of soil-borne pathogens like Fusarium oxysporum f. sp. ciceri, which causes root rot disease and severely affects productivity. The putative transgenic plants were obtained with the Radish defensin (Rs-AFP2) gene through Agrobacterium tumefaciens mediated transformation using the embryo axis explants. Transgenes were confirmed in 18 putative transgenic plants with PCR-specific primers for nptII and Rs-AFP2 genes. Twelve transgenic plants were established successfully under greenhouse conditions. The T0 plants were allowed for self-pollination and obtained T1 seeds. The T1 plants were selected for Fusarium wilt assay using Fusarium oxysporum f. sp. ciceri. The T1 plants showed different resistance levels, from moderate to high levels. The control plants (wild-type) exhibited severe wilt symptoms after Fusarium infection.
Enhancing the Solubility of Active Pharmaceutical Ingredients using Deep Eutectic Solvents to Develop Liquid Oral Formulations
Authors: Pascual-Fernández Leyre , Bergua Fernando , Artal Manuela , Lafuente Carlos , Giner Beatriz
Published: July 2022

Few oral liquid formulations of poorly soluble drugs are available. In this study, we explore the use of several hydrophobic deep eutectic solvents (DESs) formed by the binary combination of thymol, menthol, and camphor (1:1 thymol:camphor, 2:1 menthol:camphor, and 1:1 thymol:menthol) to increase the solubility of furosemide, tetracycline, nitrofurantoin, carvedilol, and quercetin. The maximum solubility of the studied drugs in different DESs was experimentally measured using a modification of the shake-flask method. The results indicate that the solubility of all five chemicals is more than 50 times higher than the aqueous solubility, and the solubility of quercetin in 2:1 menthol:camphor is especially remarkable (nearly 7000 times the aqueous solubility). A calculation of the DES volume required for the maximum adult dose for each drug shows the oral liquid formulations can be prepared for tetracycline and carvedilol using the three studied DESs and for furosemide using 2:1 menthol:camphor. However, stability and formulation studies need to be performed to ensure that the oral liquid formulations prepared with these solvents comply with pharmacopeia requirements.
Is suboptimal circulating level of vitamin D a risk factor for the poor prognosis of COVID- 19? – A comparison of first and second waves in India
Authors: Charla Yashika , Bhagava Seema , Bembey Shyamala A , Byotra S. P. , Kakar Atul , Gogia Atul , Chugh Parul , Choudhury Sangeeta
Published: July 2022

Background
- Severe acute respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) affects every organ system, especially the lungs. Vitamin D has been shown to modulate both infections and autoimmune diseases. It maintains the balance between angiotensin-1 and angiotensin II, thereby preventing lung tissue damage. Hence arises the question - can adequate circulating vitamin D prevent or modulate SARS-CoV-2 infection? In the present study, we attempted to find the answer to this question in the Indian population.
Methodology
-The study duration was April 1, 2020 to April 30, 2021, including only those patients whose vitamin D levels were estimated. Mann-Whitney test was used to compare age, hospital stay, and total vitamin D levels between the two waves. The gender difference, vitamin D status, pre-existing comorbidities, COVID-19 severity, and mortality were calculated using the chi-square test.
Results
- On curating the data, vitamin D levels were found to be estimated in 179 COVID-19 positive patients. In the first wave, 48.2% of the patients were deficient in vitamin D levels, yet no statistical association was observed for patients’ demographics (age, sex, and comorbidities), COVID-19 severity, and mortality. Similar results were observed in the second wave. The correlation coefficient of IL-6 (r=-0.08), CRP (r = 0.033), and ferritin (r = 0.027) was not significantly associated with vitamin D levels.
Conclusion
- The Indian population is known to be deficient in vitamin D, yet this study showed an absence of vitamin D correlation with severity, morbidity or mortality of COVID-19. Further research into the immune-modulatory effect of vitamin D on disease susceptibility and progression in COVID-19 would be beneficial.
Real-time motion amplification on mobile devices
Authors: Voss Henning
Published: July 2022

A simple motion amplification algorithm suitable for real-time applications on mobile devices is presented. It is based on motion enhancement by moving average differencing (MEMAD), a temporal high-pass filter for video streams. MEMAD can amplify small moving objects or subtle motion in larger objects. It is computationally sufficiently simple to be implemented in real time on smartphones. In the specific implementation as an Android phone app, MEMAD is demonstrated on examples chosen such as to motivate applications in the engineering, biological, and medical sciences.
Imatinib protects against dexamethasone-induced pancreatic β-cell apoptosis via downregulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and death receptor 5 (DR5)
Authors: Kutpruek Suchanoot , Suksri Kanchana , Maneethorn Petcharee , Semprasert Namoiy , Yenchitsomanus Pa-thai , Kooptiwut Suwattanee
Published: July 2022

Long-term treatment of inflammation using dexamethasone can induce diabetes, which is referred to as steroid-induced diabetes. It has been shown that imatinib, which is a drug that is used to treat chronic myeloid leukemia (CML), is able to ameliorate diabetes in CML patients. Our group recently reported that dexamethasone could induce pancreatic β-cell apoptosis via upregulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor, death receptor 5 (DR5). We, therefore, hypothesized that imatinib protects against dexamethasone-induced pancreatic β-cell apoptosis via downregulation of TRAIL and DR5, which favorably influences downstream molecules in apoptotic pathways. To test this hypothesis, we examined the effects of imatinib on dexamethasone-induced INS-1 (rat insulinoma cell line) cell apoptosis. As expected, dexamethasone-induced INS-1 cell apoptosis was associated with upregulation of TRAIL, DR5, and superoxide production, but with downregulation of TRAIL decoy receptor (DcR1). The downstream molecules in the extrinsic and intrinsic apoptosis pathways, including Bax, NF-κB, p73, caspase 8, and caspase 9, were also upregulated, but the anti-apoptotic protein Bcl-2 was downregulated. Interestingly and importantly, imatinib 10 µM could reverse the effects of dexamethasone on TRAIL, DR5, DcR1, superoxide production, Bax, Bcl-2, NF-κB, p73, caspase 3, caspase 8, and caspase 9. Similar effects of imatinib on dexamethasone-induced TRAIL and DR5 expression in isolated mouse islets were also observed. These results indicate that imatinib protects against dexamethasone-induced pancreatic β-cell apoptosis via downregulation of TRAIL and DR5, and via alteration of downstream molecules in the extrinsic and intrinsic apoptosis pathways.
Osteoblastoma and Plagiocephaly of an Iron Age individual from Ya’amun, Northern Jordan
Authors: Alrousan Mohammad , Al-Shorman Abdulla , Pérez-Pérez Alejandro
Published: July 2022

Little is known about the skeletal biology of the Iron Age inhabitants in Jordan, where this study comes to contribute to the previously described diseases of the same period. A single Iron Age skeleton that was unearthed at the site of Ya'amun in northern Jordan is presented. The subject was a male who died at the age of about 30 years old. Paleopathological investigations were performed using anthroposcopy and radiography. The analyses revealed many pathological lesions, including osteobalsoma of the right femur, craniosysntosis, plagiocephaly, asymmetry of the sacrum, fractures of the vertebrae, anemia, and osteoarthritis. This case marks the first example of neoplasm and plagiocephaly in the Iron Age of Jordan. Although the individual had survived serious health problems, he reached his third decade enduring intense daily activities representing the challenging living and subsistence conditions during the Iron Age.
IGSF6 is a prognostic biomarker associated with the anti-tumor activity of macrophages in lung adenocarcinoma
Authors: Zheng Qisi , Li Miao , Li Rong , Shen Han , Zhang Zhi , Tian Xinyu
Published: July 2022

Background
Immunoglobulin superfamily 6 (IGSF6) is a novel member of the immunoglobulin superfamily, and it is related to a variety of human diseases. However, the association of IGSF6 with the prognosis and anti-tumor immune response of lung adenocarcinoma (LUAD) remains unknown.
Methods
IGSF6 expression in pan-cancer and LUAD data of The Cancer Genome Atlas (TCGA) was analyzed by TIMER2.0 and GEPIA2, respectively. Quantitative-real-time-PCR (qRT-PCR), western-blot and immunohistochemistry (IHC) staining were performed to confirm the result of bioinformatics. IGSF6 expression level and promoter methylation level from major clinical features were analyzed by using UALCAN. Survival curves were used to assess the connection between IGSF6 expression and LUAD prognosis. The enrichment analysis was conducted by running the R software clusterProfiler package. TISIDB and Timer2.0 were utilized to investigate the association of IGSF6 with tumor infiltrating lymphocytes (TILs) in LUAD. Human Protein Atlas (HPA) and flow cytometry (FCM) were used to confirm IGSF6 localization in macrophages.
Results
IGSF6 expression was decreased in different types of cancers including LUAD. qRT-PCR, western-blot and IHC staining further confirmed this finding in paired tumor and normal tissues of LUAD patients. Meanwhile, promoter methylation level of IGSF6 in LUAD samples increased compared to that in peritumor samples, implying a potential mechanism that leads to the aberrant expression of IGSF6 in LUAD. By estimating the correlation between IGSF6 expression and the prognosis of LUAD, we found that low IGSF6 expression was significantly related to a worse survival rate. The enrichment analysis of IGSF6 co-expression showed that IGSF6 expression was closely associated with gene sets involved in immune cell proliferation and exogenous antigen presentation. In addition, high IGSF6 expression was positively correlated with immune infiltrates with anti-tumor activity, including M1 macropahges, dendritic cells (DCs), and T helper 1 (Th1) cells. Finally, IGSF6 was indicated to be mainly located on the membrane of macrophages in LUAD, which might enable exogenous antigen uptake and presentation so as to regulate immune response.
Conclusions
IGSF6 is a prognostic biomarker for LUAD, which may promote the anti-tumor immune response leading to ameliorative prognosis.
Pricing Modern Life Insurance Products using Phase-Type Models for Iran
Authors: Haghighi Mohammad Hossein Nezhad
Published: July 2022

Due to their flexible benefits, equity-linked products are becoming more and more common in the life insurance industry.The present study takes into account the guaranteed minimum death benefit and high-water benefit as two life insurance products. In addition, the underlying asset process is subjected to the jump-diffusion process with phase-type jumps. First, for modeling the lifetime data taken from the Iranian and UK life tables, we chose Canonical Form 1 rather than the Coxian form of phase-type distribution. The two most recent programs, mapfit.r and EMpht.jl, can evaluate this fit. Additionally, the Monte-Carlo approach is used to compare the variability in both products' prices for each country with varied interest and discount rates.The K-S test demonstrated an adequate fit to Iran's lifetime data with 150 phases and a 76.7-year life expectancy (Iran did not have gender-separated data), and UK lifetime data with 200 phases with an 81.8-year life expectancy. Additionally, using mapfit.r, running times for CF1 are less than 20 minutes as opposed to those for Coxian. The outcomes suggest that the prices differ in terms of interest rate, discount rate, the number of fitting phases, and the value of the underlying asset. Additionally, the lack of accuracy in modeling will result in overpricing. The prices ultimately are more volatile the larger the discount rate.
α-Synuclein induces deficiency in clathrin-mediated endocytosis through inhibiting synaptojanin1 expression
Authors: Song Dong-Yan , Yuan Lin , Cui Na , Feng Cong , Meng Lanxia , Wang Xin-He , Xiang Man , Liu Di , Wang Chun , Zhang Zhentao , Li Jia-Yi , LI WEN
Published: July 2022

Background
Parkinson’s disease (PD) is mainly characterized by the pathological feature of α-synuclein (α-syn) aggregation, with the exact disease pathogenesis unclear. During the onset and progression of PD, synaptic dysfunction including dysregulation of axonal transport, impaired exocytosis and endocytosis are identified as crucial events of PD pathogenesis. It has been reported that overexpression of α-syn impairs clathrin-mediated endocytosis (CME) in the synapses. However, the underlying mechanisms remained unknown.
Methods
In this study, we investigated the molecular events underlying the synaptic dysfunction induced by overexpression of wild-type human α-syn and its mutant form, involving series of proteins participating in CME.
Results
We found that excessive human α-syn causes impaired fission and uncoating of clathrin-coated vesicles (CCVs) during synaptic vesicle recycling, leading to reduced clustering of synaptic vesicles near the active zone and increased size of plasma membrane and number of endocytic intermediates. Furthermore, overexpressed human α-syn induced changes of CME associated proteins, among which synaptojanin1 (SYNJ1) showed significant reduction in various brain regions. Overexpression of SYNJ1 in the primary neuron of α-syn transgenic mice recovered the synaptic vesicle density and clustering. Using fluorescence-conjugated transferrin, we demonstrated that SYNJ1 re-boosted the CME activity by restoring the phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] homeostasis.
Conclusions
In summary, our data suggested that overexpression of α-syn disrupts synaptic function through interfering with vesicle recycling, which could be alleviated by re-availing of SYNJ1. Our study unrevealed a molecular mechanism of the synaptic dysfunction in PD pathogenesis and provided a potential therapeutic target for treating PD.
Reliability and validity of ICU nurses' knowledge-attitude-practice scale for post-ICU syndrome in critically ill patients
Authors: cheng zhiqiang , zhang baozhen , xia jiaoyun , wang xiaoxing
Published: July 2022

Background: Post-ICU syndrome has not been paid enough attention in Chinese medical institutions. Due to the large population base in my country, the number of people with post-ICU syndrome is also large, which has a great impact on the quality of life of patients in the later period.Objective To develop and verify ICU nurses' knowledge, attitude and practice questionnaire on post-ICU syndrome in critically ill patients, to provide a basis for the investigation of post-ICU syndrome status.Methods Using the principle of Knowledge, Attitude and Practice (KAP), a questionnaire item database was created through literature review and semi-structured interviews. The questionnaire was modified by Delphi expert correspondence method and pre-investigation. 451 ICU nurses were selected for formal investigation, and the reliability of the questionnaire was evaluated degree test.Results A questionnaire of knowledge, attitude, and practice of ICU nurses on post-ICU syndrome in critically ill patients was formed, in which the number of items in the three dimensions of knowledge, attitude, and practice were 11, 7, and 13, respectively. The Pearson correlation coefficient between dimensions and the total score of the questionnaire ranged from 0.526 to 0.860, and the correlation coefficients between items and dimensions ranged from 0.517 to 0.921 (P＜0.001). Item content validity (I-CVI) ranged from 0.867 to 1, and questionnaire content validity (S-CVI) =0.989. Four common factors were extracted by exploratory factor analysis, and the cumulative variance explanation rate was 76.214%. Confirmatory factor analysis: Chi-square ratio of degrees of freedom (χ2/df) =2.789, RMSEA=0.077, RMR=0.048, GFI=0.947, CFI=0.922, NFI=0.943, IFI=0.922, TLI=0.915. The Cronbach's alpha coefficients of the questionnaire and dimension were 0.948, 0.976, 0.966, 0.910, split-half reliability = 0.951, and test-retest reliability = 0.927.Conclusion The reliability and validity of the questionnaire meets the requirements of questionnaire preparation, and can reflect the knowledge, belief, and behavior of ICU nurses in post-ICU syndrome.
Signs of ultra-high-energy electrons emission with energy up to 105 times of beam energy are detected at downstream of the RF cavity of storage ring
Authors: Qian Dapeng
Published: July 2022

In a new version of special relativity that absorbed the uncertainty principle, the Einstein-Lorentz mass formula proved to be a special case of a more universal equation. The new equation indicates that there is a “high speed but low mass” weak effect in particle motion, which will cause the generation of abnormal ultra-high energy electrons with a small probability when an electron beam passes through an accelerating electric field. The author used the method of long-times accumulation detection to test it on the BEPCII, which results show that there is indeed emission of abnormal electrons with energy up to 105 times of the beam energy at the downstream of the RF cavity of the electron storage ring. Therefor, it is suggested to use the detector with an online real-time display function, such as the “Shashlyk calorimeter”, to detect the single event of ultra-high energy electron, so to fully verify this previously unknown phenomenon and further discover new physics.
Nontargeted Metabolomics Analysis of Oxacillin Resistance in Staphylococcus Aureus
Authors: Liu Jingjing , Qi Mingyang , Yuan Zichen , Wong Tin-Yan , Song Xiaofeng
Published: July 2022

BackgroundStaphylococcus aureus has acquired resistance to antibiotics in the long-term struggle against antibiotics. Treatment of Staphylococcus aureus infection has become more difficult. In this study, based on nontargeted metabolic figure printing technique, the metabolome of a pair of isogenic methicillin-susceptible and resistant Staphylococcus aureus (MSSA and MRSA) strains treated with the sublethal dose of oxacillin was characterize to investigate the mechanism of antibiotic resistance.ResultsMassive alternations of metabolite expression were observed in both MSSA and MRSA treated with oxacillin. The results of accurate mass and mass fragmentation analysis showed that 7 and 29 metabolites of MRSA and MSSA have changed significantly after oxacillin treatment. The dysregulated metabolites suggested that CoA and fatty acids could help Staphylococcus aureus survive under antibiotic stress. Metabolic pathways engaged in antibiotic resistance were discovered through pathway enrichment analysis. The enriched pathways suggested that DNA repairing and flavin biosynthesis are universal pathways to help MSSA and MRSA survive under antibiotic stress. Compared with MSSA, MRSA systematically and effectively fight against oxacillin through precisely controlling energy producing, PBP2a substrate biosynthesis and antioxidant function. ConclusionsCoenzyme A and fatty acids help both MSSA and MRSA survive under the antibiotic stress. MSSA was susceptible to oxacillin and was forced to response. On the contrary, MRSA systematically and effectively fight against oxacillin. The different metabolome responses of MSSA and MRSA provide us with new insights into how Staphylococcus aureus develops antibiotics resistance.
Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis
Authors: Alymenko M. A. , Valiev R. Sh. , Polonikov A. V. , Golubeva T. N. , Vasilevskaya A. P. , Miroshnik E. V.
Published: July 2022

The objective: to investigate the relationship of polymorphic variants of genes of xenobiotic biotransformation metabolism enzymes (NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)), GSTM1 (E/D), GSTT1 (E/D) with the risk of pulmonary tuberculosis.

Subjects and Methods. Within the framework of this study, a population sample of unrelated 1081 individuals of Slavic nationalities (mainly Russians) living in the territory of Kursk Oblast was used.

Results. The del/del (D/D) GSTM1 genotype was associated with an increased risk of developing tuberculosis, while carrying the del/del (D/D) GSTT1 genotype was associated with a lower risk of developing the disease. Polymorphism 3435T>C ABCB1 (TC genotype) was associated with increased susceptibility to pulmonary tuberculosis in the codominization model, while TT+TC genotypes had the same association in the dominance model.
Dark matter searches with mono-photon signature at future e$^+$e$^-$ colliders
Authors: Kalinowski Jan , Kotlarski Wojciech , Mekala Krzysztof , Sopicki Pawel , Zarnecki Aleksander Filip
Published: July 2022

As any e^++e^-−
scattering process can be accompanied by a hard photon emission from the
initial state radiation, the analysis of the energy spectrum and angular
distributions of those photons can be used to search for hard processes
with an invisible final state. Thus high energy
e^++e^-−
colliders offer a unique possibility for the most general search of Dark
matter based on the mono-photon signature. We consider production of DM particles via a mediator exchange at the
International Linear Collider (ILC) and Compact Linear Collider (CLIC)
experiments taking into account detector effects within the Delphes fast
simulation framework. Limits on the light DM production in a generic
model are set for a wide range of mediator masses and widths. For
mediator masses up to the centre-of-mass energy of the collider, results
from the mono-photon analysis are more stringent than the limits
expected from direct resonance searches in Standard Model decay
channels.
Pair production of charged IDM scalars at high energy CLIC
Authors: Klamka Jan
Published: July 2022

The Compact Linear Collider (CLIC) was proposed as the next
energy-frontier infrastructure at CERN, to study
e^++e^-−
collisions at three centre-of-mass energy stages: 380,GeV, 1.5,TeV and
3,TeV. The main goal of its high-energy stages is to search for the new
physics beyond the Standard Model (SM). The Inert Doublet Model (IDM) is
one of the simplest SM extensions and introduces four new scalar
particles: H^\pm±,
A and H; the lightest, H, is stable and hence a natural dark matter (DM)
candidate. A set of benchmark points is considered, which are consistent
with current theoretical and experimental constraints and promise
detectable signals at future colliders.

Prospects for observing pair-production of the IDM scalars at CLIC
were previously studied using signatures with two leptons in the final
state. In the current study, discovery reach for the IDM charged scalar
pair-production is considered for the semi-leptonic final state at the
two high-energy CLIC stages. Full simulation analysis, based on the
current CLIC detector model, is presented for five selected IDM
scenarios. Results are then extended to the larger set of benchmarks
using the Delphes fast simulation framework. The CLIC detector model for
Delphes has been modified to take pile-up contribution from the
beam-induced \gamma\gammaγγ
interactions into account, which is crucial for the presented analysis.
Results of the study indicate that heavy, charged IDM scalars can be
discovered at CLIC for most of the proposed benchmark scenarios, with
very high statistical significance.
Simultaneous Extraction of Unpolarized PDFs and Nuclear Effects
Authors: Cocuzza Christopher , Metz Andreas , Sato Nobuo
Published: July 2022

We present a new global QCD analysis of unpolarized parton distribution functions (PDFs) and nuclear effects including for the first time data from the SeaQuest and Marathon experiments in addition to high-energy weak-boson-production data from the Tevatron and Large Hadron Collider. Simultaneously extracting the PDFs and nuclear effects, we examine the impact of the SeaQuest and Marathon data on the light-quark sea asymmetry and the EMC ratios of deuterium, helium, and tritium.
Azimuthal correlations in diffractive scattering at the Electron-Ion Collider
Authors: Dumitru Adrian , Mäntysaari Heikki , Paatelainen Risto , Roy Kaushik , Salazar Farid , Schenke Björn Peter
Published: July 2022

We calculate azimuthal correlations between the exclusively produced vector meson and the scattered electron in Deep Inelastic Scattering processes at the future Electron-Ion Collider (EIC). We identify ``kinematical'' and ``intrinsic'' contributions to these correlations, and show that the correlations are sensitive to the non-trivial correlations in the gluon distribution of the target. Realistic predictions at the EIC kinematics are provided using two different approaches to describe the dipole-proton interaction at relatively small x.
Single-Logarithmic Corrections to Small-$x$ Helicity Evolution
Authors: Tawabutr Yossathorn
Published: July 2022

The small-xx
quark helicity evolution equations at double-logarithmic order, with the
kernel \sim\alpha_s\ln^2(1/x)∼αsln2(1/x),
have been derived previously. In this
work, we derive the single-logarithmic corrections to the equations, to
order \alpha_s\ln(1/x)αsln(1/x)
of the evolution kernel. The new equations include the effects of the
running coupling and the unpolarized
small-xx
evolution, both of which are parametrically significant at
single-logarithmic order. The large-N_cNc
and large-N_c\ N_fNcNf
approximations to the equation are computed. (Here,
N_cNc
and N_fNf
are the numbers of quark colors and flavors, respectively.) Their
solutions will provide more precise estimates of the quark helicity
distribution at small xx,
contributing to the resolution of the proton spin puzzle.
Coherent photoproduction of $J/\psi$ in nucleus-nucleus collisions \\in the color dipole approach- an update
Authors: Luszczak Agnieszka , Schäfer Wolfgang
Published: July 2022

We discuss the role of c \bar c gcc‾g-Fock
states in the diffractive photoproduction of
J/\psiJ/ψ-mesons.
We build on our earlier description of the process in the color-dipole
approach, where we took into account the rescattering of
c \bar ccc‾
pairs using a Glauber-Gribov form of the dipole-nucleus amplitude. We
compare the results of our calculations to recent data on the
photoproduction of J/\psiJ/ψ
by the ALICE and LHCb collaborations.
Future Physics Prospects with the CMS Detector at the High-Luminosity LHC
Authors: Henderson Conor
Published: July 2022

The High-Luminosity Large Hadron Collider is expected to deliver up
to 3000 fb^{-1}−1
of proton-proton collisions at 14 TeV center-of-mass energy. We present
prospects for selected heavy-ion, Standard Model and Higgs sector
measurements with the CMS detector at the HL-LHC, and discuss potential
sensitivity to several beyond-Standard Model new physics scenarios.
Momentum transfer dependence of heavy quarkonium electroproduction
Authors: Krelina Michal , Nemchik Jan
Published: July 2022

We investigate the momentum transfer dependence of differential cross
sections d\sigma/dtdσ/dt
in diffractive electroproduction of heavy quarkonia on proton targets.
Model predictions for d\sigma/dtdσ/dt
within the light-front QCD dipole formalism are based on a realistic
model for a proper correlation between the impact parameter
\vec bb⃗
of a collision and color dipole orientation
\vec rr⃗.
We demonstrate a significance of \vec b-\vec rb⃗−r⃗
correlation by comparing with a standard simplification
\vec{b}\parallel\vec{r}b⃗∥r⃗,
frequently used in the literature.
Central exclusive diffractive production of axial-vector $f_{1}$ mesons in proton-proton collisions
Authors: Lebiedowicz Piotr , Leutgeb Josef , Nachtmann Otto , Rebhan Anton , Szczurek Antoni
Published: July 2022

Exclusive production of axial-vector f_{1}(1285)f1(1285)
meson in proton-proton collisions via pomeron-pomeron fusion within the
tensor-pomeron approach is discussed. Two ways to construct the
pomeron-pomeron-f_{1}f1
coupling are presented. We adjust the parameters of our model to the
WA102 experimental data and compare with predictions of the
Sakai-Sugimoto model. Predictions for LHC experiments are given.
Determination of the rapidity evolution kernel from Drell-Yan data at low transverse momenta
Authors: Hautmann Francesco , Scimemi Ignazio , Vladimirov Alexey
Published: July 2022

We report recent results on the extraction of the rapidity evolution kernel for Sudakov processes from
experimental measurements of Drell-Yan (DY) transverse momentum distributions. We
discuss the role of high-precision Large Hadron Collider (LHC) data, and illustrate
the interplay of this analysis with transverse momentum dependent and collinear parton density functions.
Particle Physics with the Pierre Auger Observatory
Authors: Perlin Matias
Published: July 2022

The Pierre Auger Observatory is the largest extensive air shower
detector. Based on a hybrid system, this experiment measures the longitudinal shower development
and the particles at the ground.
This detection system allows the extraction of the p-air cross-section at energies much
higher than the ones accessible by current colliders.
It is also possible to test hadronic interaction models using correlations between different air shower
observables, like the depth of shower maximum and the muon number at the ground and their fluctuations.
Thanks to the low energy extension of the Pierre Auger Observatory, the muon deficit in air shower
simulations can be addressed over almost three decades at the highest energies.
SAFETY AND EFFICACY OF SILODOSIN-DUTASTERIDE IN THE MANAGEMENT OF BENIGNPROSTATIC HYPERPLASIA
Authors:   Department of Pharmacy Practice, Hindu College Of Pharmacy, Amaravathi Road, Guntur., Sadasiva Rao G. , Sudharani K. ,   Department of Pharmacy Practice, Hindu College Of Pharmacy, Amaravathi Road, Guntur., Salma Sulthana Sk. ,   Department of Pharmacy Practice, Hindu College Of Pharmacy, Amaravathi Road, Guntur., Sunita K. ,   Department of Pharmacy Practice, Hindu College Of Pharmacy, Amaravathi Road, Guntur., Lakshmi Kranthi M. ,   Department of Pharmacy Practice, Hindu College Of Pharmacy, Amaravathi Road, Guntur.
Published: July 2022

Background Information: Currently alpha1-adrenoreceptor blockers with the combination of 5- alpha reductase inhibitors are widely used as first-line therapy to improve Lower urinary tract symptoms (LUTS) associated with Benign Prostatic Hyperplasia (BPH). Aims And Objectives:The aim of this study was to evaluate the Efficacy of combination drug Silodosin and Dutasteride in Benign Prostatic Hyperplasia patients with mild to severe symptoms. Materials And Methods:Thepresent hospital based Prospective Interventional Observational study was conducted in Department of Urology and Surgery out and inpatient Department,Lalitha Super Speciality Hospital during the time period of 1st October 2020 to 31st March 2021 and 70 cases of BPH with mild to severe symptoms and prostate volume of greater than30cc were included in the study All the patients were administered the drug which is a combination of Silodosin (8mg) and Dutasteride (0.5mg) once daily for 3 months after obtaining ethical clearance and administering informed consent .The patients condition was done followupfor the changes in Prostate Size,PVR,IPSS which were recorded and analysed using appropriate statistical tools. Results: The study showed that there was a significant decrease in prostate size when compared with before treatment i.e.11.31Â±5.99and a significant decrease in PostVoidResidual volume when compared with before treatment i.e 43.95Â±1.091.During therapy the IPSS score was improved to 9.5Â±1.567 which was found to be statistically significant (p<0.05).After 2 months of the treatment there was improvement in the patient condition ,as we saw the significant change in prostate size, post void residual volume and IPSS score after treatment.The patient with severe, moderateand mild benign prostate hyperplasia was improved by the treatment . Conclusion: There is statistically significant improvement in PVR ,IPSS and prostate size .Thus Silodosin 8mg and dutasteride 0.5mg can be used for effective relief of LUTS caused due to BPH in mild to severe cases.
Recuperación feminista de la categoría de ley natural
Authors: Di Renzo Gabriela
Published: July 2022

El estudio plantea una recuperación de la categoría de ley natural, desde los aportes de la teología feminista. La problemática de la ley natural que estructura y fundamenta la ética teológica del magisterio católico, se fue entretejiendo en el tiempo y su gran sistematizador fue Santo Tomas De Aquino. La teología feminista, surgida de las teorías feministas sustenta como principio crítico la promoción de la plena humanidad de las mujeres y asume que los textos y las tradiciones de la comunidad cristiana o las marcas de su recepción a lo largo de la historia, funcionan a partir de una concepción errónea de la mujer.  Esto ha configurado para ellas un ethos a partir de una visión estática y esencialista de su naturaleza.  La teología feminista es consciente de la necesidad de reflexionar a partir de una antropología igualitaria que incluya y haga partícipes a las mujeres del bien humano de la misma manera que a los varones, y a la vez permita visualizar las diferentes maneras en que varones y mujeres experimentan sus vidas. Esta reflexión encarnada sobre los bienes a los que estamos dirigidos y el descubrimiento de los medios necesarios para lograrlos integra la comprensión de la ley natural
Análise Retórica de 2Pedro 3,14-16
Authors: Gonzaga Waldecir , Ferreira Belem Doaldo
Published: July 2022

O presente trabalho objetiva uma exegese da perícope de 2Pd 3,14-16, pertencente a uma das cartas católicas e deuterocanônicas do Novo Testamento. Para tal, utilizaremos as regras de Análise Retórica Bíblica Semítica, propostas pelo estudioso francês Roland Meynet, e, mediante esse método, podemos verificar a centralidade das Escrituras paulinas e do problema acerca de sua correta interpretação. Longe de supervalorizar esses escritos, o hagiógrafo reclama que não somente esses são distorcidos, mas igualmente também as outras Escrituras. Esta centralidade coloca Paulo como exemplo a ser seguido pelos fiéis, os quais são opostos verazmente aos “falsos mestres”, que, desqualificando as Escrituras, colocam-se diametralmente opostos igualmente ao “amado Paulo”.
Del ente en el mundo al mundo en el ente. Introducción al concepto cosmológico de mundo de Eugen Fink
Authors: Garrido-Maturano Ángel Enrique
Published: July 2022

El artículo introduce la noción cosmológica de mundo de Eugen Fink. Para ello la distingue primero del mundo concebido como recipiente a partir del “ser en” el mundo de los entes cósicos. Luego la diferencia del mundo concebido como existenciario  a partir del “ser en” el mundo del hombre. Posteriormente explicita el mundo cosmológico como unicidad, espacio-tiempo y movimiento ontogénico de individuación y aparición. La explicitación se orienta a poner de manifiesto el carácter originario del mundo cosmológico desde el punto de vista trascendental. Finalmente analiza el fenómeno fundamental del juego como modelo operativo que reproduce el imperar del mundo en el ámbito intramundano y, sobre la base del análisis del juego, muestra en qué medida la noción cosmológica de mundo de Fink puede representar un punto común en el que se encuentren las cosmologías científicas y la visión religiosa del mundo.