bluuebunny/crossref_metadata_2025 huggingface dataset:
Solid self‑emulsifying pellets: Solubility enhancement for oral delivery of poorly soluble BCS Class II drug
Authors: Rupvate Smita Rajendra , Gangurde Subodh Anil , Adavadkar Priyanka Rajendra , Ukhade Snehal Sampat , Lale Shivam Suresh
Published: August 2022

The review focused on technique of solid self-emulsifying pellets (SEPs) for solubility enhancement of poorly water soluble drug. The oral route of administration has been and still is currently the primary route of drug delivery owing to its potential advantages compared to the other routes. The solubility enhancement process of hydrophobic drugs plays a key role in the formulation development to achieve the bioavailability and therapeutic action of the drug at the target site.1 Around 40% of probe new drugs are characterized as belonging to class II in the BCS classification (poorly water soluble and highly permeable), giving rise to poor and erratic oral bioavailability. The solid SEPs system combines the advantages of liquid Self emulsifying drug delivery system with those of solid dosage form, which can overcome the limitations of liquid formulations and improve the storage stability and patient compliance. To enhance the dissolution and oral absorption of water insoluble drug selfmicroemulsifying pellets develop and evaluated. SEPs pellets showed a significant quicker redispersion rate than the dissolution rate of commercial tablets. The solid SEPs pellets might be an encouraging strategy to improve the oral absorption of Poorly water soluble drug and the extrusion–spheronization method is a feasible technology for the solidification of liquid SMEPs. Self microemulsifying drug delivery system (SEPs) as an effective bioavailability enhancement pharmaceutical technology has been widely used during the recent years and have some successful products in the market (e.g. Neoral®, Norvir® and Fortovase®).

Keywords: Self Emulsifying Pellets, Bioavailability, Solubility, extrusion–spheronization, Biopharmaceutical Classification.
Phytochemical screening and GC-MS analysis of bioactive compounds in Caesalpinia bonduc L. from Alagarkovil Reserve Forest (ARF), Dindigul District, South India
Authors: Grace Lydial Pushpalatha G , Abraham GC
Published: August 2022

The popularly known Kazharchi Kai (Tamil), Caesalpinia bonduc L. (Fam: Caesalpiniaceae) is a traditional medicinal plant widely distributed in India which finds use as a therapeutic in indigenous systems of medicine such as Ayurveda, Siddha, Unani and Homoeopathy is a herbal remedy for  treating of various ailments. The plant has been reported for its anticancer, hepatoprotective, antioxidant, antimalarial, antimicrobial, antipyretic, antifertility, anti-inflammatory and antimalarial properties. In particular C. bonduc seeds contain cassane diterpenoids viz., caesalpinins and caesalmins, cassane diterpenoids, and norcassane diterpenoids. This plant contains bioactive secondary metabolites (BASM) with unique structures and diverse mechanisms of action that can be well exploited to finetune novel therapeutic herbal formulations. In the present study an attempt has been made to screen for bioactive metabolites in the seed extracts of C. bonduc followed by GCMS analysis. GCMS analysis indicated the presence of 2,2,3,5-tetramethylheptane, (Z)-hept-2-enal, 2,2,3,5-tetramethylheptane, 3,3- dimethyloctane, 5-ethyl-2,2,3-trimethylheptane, 2,6,10-trimethyldodecane, 3- methylnonane, 3,8-dimethylundecane, 6-Ethyl-3,8-dimethylundecane, 2,3,4- trimethyldecane, 3-Methyldecane, (2E,4E)-deca-2,4-dienal, (1R,4E,9S)-4,11,11- trimethyl-8-methylidenebicyclo[7.2]undec-4-ene, Hexadecanoic acid, methyl (9Z,12Z)-octadeca-9,12-dienoate, (9Z)-octadeca-9,17-dienal, 2- (ethylhexoxycarbonyl) benzoic acid. Of all, compounds such as Hexadecanoic acid, methyl (9Z,12Z)-octadeca-9,12-dienoate, and (9Z)-octadeca-9,17-dienal with unusual bioactivity score could serve as promising lead candidate for the design of novel anticancer drug, In-silico predictions of molecular and biological activity of these bioactive compounds phytocompounds could pave way for its effective utilization   in pharma industry scale as a potential candidate towards biomedical applications. However, before such an exercise, in-silico ADMET pharmacoinformatic studies followed by pre-clinical and clinical trials pursued in this exercise may well be required for its launch into the global pharma-market on commercial scale.

Keywords: Phytochemical Screening; Bioactive Secondary Metabolites (BASM); GCMS; Medicinal Plant; Ethnobotany; CBSPEE; PBNPs
A study on Formulation and Evaluation of Gastroretentive tablet incorporating Ciprofloxacin Hydrochloride
Authors: Mehetre Gautam D. , Thenge Raju R. , Chinchole Pavan P. , Narkhede Mahesh B. , Babhulkar Mukesh W.
Published: August 2022

Ciprofloxacin is a broad spectrum fluoroquinolone antibiotic effective in a broad range of infections including some difficult to treat ones. Because of wide-spectrum bactericidal activity, oral efficacy and good tolerability, it is used in Urinary tract infection, Gonorrhea, Bacterial gastroenteritis, Typhoid, Bone, soft tissue and gynecological infection, Respiratory infection and tuberculosis. The main objective of formulating the floating system was to reduce the frequency of administration, to improve patient compliance and improve bioavailability of drug by preparing a gastroretentive drug delivery system. Floating tablets of Ciprofloxacin hydrochloride were prepared by employing two different grades of control releasing polymers HPMC K4M and HPMC K100M in different concentration. Sodium bicarbonate was incorporated as a gas-generating agent. The tablets were evaluated for uniformity of weight, hardness, friability, drug content, floating behavior, swelling studies and dissolution studies. Among tablet formulations, formulation F3 showed maximum drug release i.e. 92.25% at the end of 12 h compared with other formulations and was concluded as optimized one.

Keywords: Ciprofloxacin HCl, floating tablets, HPMC K4M, HPMC K 100M, FTIR.
Incidence and severity of fungal rot of tomato and brinjal in Kashmir Valley
Authors: Koka Jahangir Abdullah , Wani Abdul Hamid , Bhat Mohd Yaqub
Published: August 2022

The incidence of fungal rot diseases of tomato and brinjal showed significant variation in different areas/localities of Srinagar, Pulwama, Anantnag and Kulgam of Kashmir surveyed during study. Incidence and severity of fungal rot of tomato and brinjal caused by several pathogenic fungi was from lowest to highest in all the surveyed districts of Kashmir Valley. Among the isolated fungi Aspergillus niger, Mucor plumbeus, Alternaria alternata and Penicillium expansum were found most commonly responsible for fungal rot of tomato and brinjal. The incidence and severity showed considerable increase during the period of study in Srinagar, Pulwama, Anantnag and Kulgam districts of Kashmir Valley and thus warrants effective management strategies. Such types of study have been carried out for the first time in the valley.

Keywords: Incidence, severity, fungal pathogens, study sites.
Comparison of the Efficiency and Safety of Oral Phenyramidol and Phenyramidol+Diclofenac Treatment in Muscle Spasms with Spinal Pain – Open-Label Study
Authors: Koyuncu Halil , Karamehmetoglu Safak Sahir , Ozcan Fatmanur Otmar , Saygisever-Faikoglu Kubra , Faikoglu Gokhan , Ozcan Yurdaer , Uskur Tugce
Published: August 2022

Muscle relaxants (MR) and nonsteroidal anti-inflammatory drugs (NSAID) are frequently used in the treatment of spasms and are effective combined or alone in muscle spasms. In this study, 30 patients aged 32-82 years, male and female, with moderate to severe acute spinal pain-muscle spasms due to trauma, sprain, or injury history were evaluated. Group 1 received phenyramidol 400 mg orally 3 times a day for 7 days. In the second group, phenyramidol (400 mg) three times a day + diclofenac (75 mg) once a day was given orally for 7 days. Patients were evaluated on the 0th and 7th days in terms of muscle spasm level, pain intensity, and side effects. Side effects were noted for clinical safety. Evaluation was performed at the start of treatment and after treatment. Compared with the adverse drug reactions that occurred during the study, Group 1 treated with phenyramidol alone showed a statistically significantly better safety profile than Group 2 treated with the combination of phenyramidol and diclofenac (p<0.001). As a result, it was observed that oral phenyramidol treatment alone and oral phenyramidol+diclofenac combination treatment did not have any difference in terms of efficacy, but when compared in terms of side effects, the use of phenyramidol alone showed a higher safety profile.

Keywords: phenyramidol, diclofenac, muscle spasm, spinal pain
ADMET informatics of Tetradecanoic acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves
Authors: Kalaimathi RV , Krishnaveni K. , Murugan M. , Basha A.N. , Gilles A Pallan , Kandeepan C. , Senthilkumar N. , Mathialagan B. , Ramya S. , Ramanathan L. , Jayakumararaj R. , Loganathan T. , Pandiarajan G. , Dhakar Ram Chand
Published: August 2022

In-silico Computer-Aided Drug Design (CADD) often comprehends virtual screening (VS) of datasets of natural pharmaco-active compounds for drug discovery protocols. Plant Based Natural Products (PBNPs) still, remains to be a prime source of pharmaco-active compounds due to their unique chemical structural scaffolds and functionalities with distinct chemical characteristic feature from natural source that are much acquiescent to drug metabolism and kinetics. In the Post-COVID-Era number of publications pertaining to PBNPs and publicly accessible plant based natural product databases (PBNPDBs) has significantly increased. Moreover, PBNPs are important sources of inspiration or starting points to develop novel therapeutic agents. However, a well-structured, in-depth ADME/Tox profile of PBNPs has been limited or lacking for many of such compounds, this hampers the successful exploitation of PBNPs by pharma industries. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties play key roles in the discovery/ development of drugs, pesticides, food additives, consumer products, and industrial chemicals. In the present study, ADMET-informatics of Tetradecanoic Acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves to predict drug metabolism and pharmacokinetics (DMPK) outcomes has been taken up. This work contributes to the deeper understanding of Myristic acid as major source of drug from commonly available medicinal plant - Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for NP based lead generation programs.

Keywords: Moringa oleifera; Secondary Metabolites; Bioactive Substances; Myristic acid (MA); DMPK; ADME/Tox; Natural Products (NPs); PBNPs; PBNPDBs
A Comprehensive Review on Bio-Adhesive Microspheres
Authors: Pandey Chandra Prakash , Archana , , Niranjan Abadhesh Kumar
Published: August 2022

A controlled medication delivery system has historically been used to produce certain rates of release or spatial concentrations of active compounds. Recent developments in drugs and polymer science delivery technology have improved innovative drug delivery systems made of bio-adhesive microspheres, advancing the use of "bio-adhesion" in drug delivery. This research evaluates the bio-adhesive MSs via transmucosal management routes, comprising the mucosal in the gastrointestinal system and other lumen, based on the advantages of adhesion arrangements and the usefulness status of MSs in mucous transport. A few new-style bio-adhesive MSs and specific studies on cell adhesive MSs are specifically mentioned. Additionally, this study aims to demonstrate the improvements made by cell-selective bio-adhesion systems known as bio-adhesive Microspheres and a few MSs with a novel bio-adhesive design are mentioned. Additionally, this evaluation aims to demonstrate the developments of site-specific medication release through stimuli-responsive MSs and bio-adhesive MSs as cell-selective bio-adhesion systems. Even if those MSs exhibit real strength, agendas need to include a few insightful ideas. In the future, processes should be closely scrutinized, and more attention should be paid to powerful bio-adhesives and "second-generation mucoadhesives." These new MSs' meaningful scientific curricula address contemporary concerns and call for further focused studies.

Keywords: Transmucosal delivery; stimuli-responsiveness; bioavailability; bioadhesive microspheres.
A Comprehensive Review on Sustained Release Matrix Drug Delivery System
Authors: Kumar Deepak , Archana , , Niranjan Abadhesh Kumar
Published: August 2022

Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as the most likely type of prolonged drug release. In order to generate therapeutic activity for a protracted duration, matrix tablets maintain a stable plasma drug concentration and sustain the rate of release of the drug throughout time. In preparations with a short half-life and high dosage frequency, extended-release is crucial. The matrix regulates how quickly the medication is released. Retardants such polyglycolic acid, polymethyl methacrylate, and hydroxypropyl methylcellulose (HPMC) are used. The retardant's matrix core contains the medication. The matrices employed can be mineral-based, hydrophobic, or biodegradable. Drug release is regulated in matrix tablets that can be made using wet granulation or direct compression techniques by the use of various kinds of polymers. Drug release from matrix tablets is controlled by both diffusion- and dissolution-controlled process. As a result, matrix tablets increase therapeutic efficacy while reducing the frequency of drug administration and increasing patient compliance.

Keywords: Sustained release, Matrix Tablets, HPMC, Retardants, Biodegradable
A Review on Emerging Benzothiazoles: Biological Aspects
Authors: Kumar Shakti , Dubey Bhavana
Published: August 2022

Due to its beneficial natural and pharmacological properties, heterocyclic element analogues and derivatives have recently received a lot of attention. One of the frequently occurring heterocyclic nuclei in both marine and natural grow solutions is benzothiazole. A favoured bicyclist band method with numerous utilizations is benzothiazole. It is well known for exhibiting a broad variety of beneficial natural activities, including those that are anticancer, antiviral, anti-inflammatory, anticonvulsant, and antidiabetic, antimicrobial, and antitubercular. The benzothiazole nucleus is used in the synthesis of many therapeutic agents. We have seen a few surprising developments in the natural functions of benzothiazole derivatives over the past few years. Due to their extraordinary pharmacological potential, these components are only relevant in the context of therapeutic hormones. This evaluation primarily aims to demonstrate recent systematic research on the various natural functions of benzothiazole compounds that has been conducted.

Keywords: Benzothiazole, Anticancer activity, antimicrobial activity, Heterocyclic element analogues, Benzothiazole derivatives
Floating Microsponge: An Emerging Drug Delivery System
Authors: Shukla Mukesh Kumar , Niranjan Abadhesh Kumar
Published: August 2022

Floating microsponges are a method to extend gastric residence time, there with the aid of using concentrated on site-responsive medicament liberate withinside the top GIT for locally or systemic effect. Gastro retentive dosage forms (GRDFs) are getting utilized from a totally long term to enhance treatment with numerous main medications. Floating microsponge significantly enhances the therapy of stomach with the aid of using liberating the medication locally and for that reason used for medication selecting at specific organ. This may be sustained over an extended period of time. Floating drug delivery allow extended and non-stop release of the drug to the top a part of Gastro intestinal tract and this expressively amplify the period of drug release and enhance pharmacokinetic of medication which have slim healing window, with the aid of using this method dosing frequency and affected person compliance is increased. A microsponge’s drug delivery system is a particularly cross-linkage, spongy, polymeric microsphere, polymeric device consisting permeable microspheres. Microsponges are prepared with the aid of using numerous techniques consisting of liquid-liquid suspension polymerization and quasi emulsion solvent diffusion method. Microsponge,s preparations are strong over variety of pH 1 to 11; microsponge,s preparations are strong  on the temperature as much as 1300C well suited with maximum vehicles and ingredients. The present assessment introduces microsponge,s technology at the side of its techniques of preparation, characterization, advantages, evaluation and release mechanism of microsponge,s drug delivery system, advertised product and up to date studies regarding  microsponge.

Keywords: Floating microsponge, Oral administration, Controlled release, Quasi emulsion, Target release.
Relationship between Body Mass Index and Knee Osteoarthritis at UKI General Hospital in 2017
Authors: Novelyn Silphia , Munthe Ronald Vinantius
Published: August 2022

Knee osteoarthritis is a degenerative joint disease usually suffered by elderly patients, contributing to the high risk of disability. The risk factors that affect the severity of knee osteoarthritis are obesity, age, sex, occupation, patient's history of the disease, trauma, and other factors. Excessive body weight is a factor that exacerbates the disease of osteoarthritis. Generally, this research is aimed to examine the correlation between Body Mass Index (BMI) and knee osteoarthritis at UKI General Hospital. The researcher used a descriptive-analytic study with a cross-sectional approach. In this study, the researcher used 30 samples. The result of chi-square analysis by using Fisher's Exact Test shows that a p-value = 0.045 indicates that the p-value of BMI is under the significance level of α = 0,05. Therefore, the researcher concluded that there is a correlation between BMI and knee osteoarthritis, in which a high BMI value (>24.9) may affect the occurrence of joint space narrowing among the patients. The mean BMI value among the osteoarthritis patients UKI General Hospital is 25.6, which highly indicates that most osteoarthritis patients are preobese/ overweight.

Keywords: Knee osteoarthritis, Body Mass Index (BMI), joint space narrowing
Advancement of Near Infrared techniques in diagnosis and treatment of cancer
Authors: Sharma Nikhil , Ankalgi Amar Deep , Thakur Upasana , Ashawat Mahendra Singh , Sharma Neha
Published: August 2022

Near-Infrared photoimmunotheraphy (NIR-PIT) is newly developed therapy for cancer treatment, by using a specific monoclonal antibody (mAb) conjugated to a photoactive agent i.e. IRDye 700DX. In this technique, the conjugate of specific monoclonal antibody - photoactive agent is administered intravenously to cancer patient. When NIR light is applied, the monoclonal antibody - photoactive agent conjugate (APC) is excited and selectively kill the cancer cell without harming neighbouring normal cell. NIR light alters the chemical structure of APC and damages the cancer cell membrane. For the diagnosis of tumor, it is possible to observe the movements of erythrocyte in tissues by using diffuse correlation spectroscopy (DCS). DCS flow measurements are carried out by observing photon speckle variations induced by moving tissue scattering. Another diagnostic tool is Near-infrared spectroscopy (NIRS), which is based on endogenous chromophores difference between healthy tissue and cancer by using diagnostic indicator i.e. oxy-haemoglobin or deoxyhaemoglobin, lipid or water bands. NIRS is being used in a variety of biological and pharmaceutical research fields, including brain imaging, cardiovascular radiology, formulation and quality/process control, and even clinical trial. In this review article, we describe the Near-Infrared photoimmunotheraphy (NIR-PIT) with its mechanism, role of DCS & NIRS in cancer diagnosis and various application of NIR-PIT.

Keyword: Near-infrared immunotherapy (NIR-PIT); diffuse correlation spectroscopy (DCS); Near-infrared spectroscopy (NIRS); Cancer treatment; Cancer diagnosis.
Benefits of a National Program for Adverse Drugs Reactions (ADRS) Surveillance in Diabetic Patients
Authors: Ramirez Irma , Vera Zully , Mastroianni Patricia , Maciel Olga , Maidana Mabel , Marin Lupe , Marin Gina , Marin Gustavo H.
Published: August 2022

Voluntary notification of suspected adverse drug reactions (ADR) is the most worldwide method to detect these events. Unfortunately, health professionals in Latin American countries have no “culture” to notify ADR. For this reason, the National Diabetes Program (NDP) in Paraguay decided to regularly contact their patients, in order to increase ADR detection. To evaluate the results of this experience, this study was performed.

Methods: a descriptive, observational, cross-sectional study with an intervention phase was performed. A non-probabilistic sample of patients belonging to NDP was selected and compared with historical results of the program. The intervention activities consisted in a monthly contact of the patients by a member of the program. 

Results: 2,390 patients with type II diabetes were enrolled in the study and compared with the same number of patients belonging to the program but with classical follow-up. Concerning the adverse drug reactions, 146 reports were registered during the study period, which mean 6.1% of all patients enrolled, while in the same period, historically the ADR reports were 0.94%. 66.9% of these reports were performed by the patients while 42.1% were notified by health professional. Main ADRs reported were vomiting 28.8%, dizziness 28.4%, diarrhea 10.8%, hypoglycemia 10.2% or abdominal pain 6.5%. The antidiabetic drugs that presented the greatest suspicion of ADRs were metformin 45.31%, glimepiride 21.8%, glibenclamide 6.25% and insulin 3.13%.

Conclusion: Periodical contact of patients covered by a National Diabetes program was able to increase 6 times the historically annual of report of pharmacovigilance adverse drug reactions.

Keywords: pharmacovigilance, adverse drug reactions, reports, voluntary, active notification, program.
Phytochemical Analysis of Clove (Syzygium aromaticum) Dried Flower Buds Extract and its Therapeutic Importance
Authors: Lone Zahoor Ahmad , Jain Navin Kumar
Published: August 2022

The current study objective was to look into phytochemical analysis of Syzygium aromaticum dried flower buds. Clove has long been known to have positive health effects. The majority of the clove spice consumed worldwide comes from home kitchens. One of the most expensive spices, clove (Syzygium aromaticum) has historically been used for both food preservation and for several therapeutic goals. Clove is a native of Indonesia, although it has been cultivated throughout the world, including India. The dried bud powder was successively extracted with water, methanol, ethyl acetate and petroleum ether. The following phytochemicals are present in Syzygium aromaticum, Carbohydrates, lipids, alkaloids, flavonoids, tannins, sterols and triterpenes are all found, according to the phytochemical examination. Clove, also known as Syzygium aromaticum (Family Myrtaceace), is the most important and second-most precious spice.  The utilization of herbal medicines is a significant source for the development of novel pharmaceutical compounds to treat severe ailments. It offers a wide range of medical benefits including antibacterial, analgesic, antioxidant, anti-inflammatory and antiseptic properties. In clove dried flower bud extract the identified compounds are Quercetin, Ursolic acid and Gallic acid, all these compounds are responsible for the medicinal properties of clove bud.

Keywords: Clove bud extract, Phytochemical, Soxhlet, LCMS, Health benefits.
Description of Covid-19 Patients with Comorbidity
Authors: Pohan Dame Joyce , Gultom Fajar Lamhot , Halim Benaya Putra
Published: August 2022

Coronavirus Disease-19 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). At this point, COVID-19 remains the main health issue worldwide, including in Indonesia, with existing risk factors. Comorbidities, smoking, male sex, and the elderly are some of its biggest risk factors. Current data about COVID-19 patients with comorbidities in Indonesia were limited, so this study was made to present more data about the clinical profile of COVID-19 with comorbidities. The descriptive retrospective method was used in this study with secondary data obtained from Christian University of Indonesia General Hospital medical records from January 2020 to December 2020 and aimed to describe the clinical profile of COVID-19 patients with comorbidities. Among 156 samples of COVID-19 patients that were found in this study according to inclusion and exclusion criteria, 91 patients (58,3%) had at least one comorbidity. They were distributed based on sex, age group, clinical symptoms, type of comorbidity, and the number of comorbidities in each patient. Based on sex distribution, there were 46 male patients (50,5%) and 45 female patients (49,5%). The most prevalent age group was 50 – 54 years old, with 14 patients (15,4%). Fever with 88 patients (95,9%), cough with 86 patients (93,8%), and dyspnea with 55 patients (60,8%) were the most common clinical symptoms. The most common types of comorbidity were hypertension with 66 patients (72,5%), diabetes mellitus (DM) with 20 patients (22,0%), and obesity with 14 patients (15,4%). There were 58 patients (63,8%) with only one comorbidity and 33 patients (36,3%) with ≥ 2 comorbidities. Prompt identification of comorbidities, public enlightenment about comorbidities with other risk factors of COVID-19, and complying with health protocols are recommended to decrease the proportion of COVID-19 patients with comorbidities.

Keywords: COVID-19, SARS-CoV-2, Comorbidity.
Formulation and Evaluation of Polyherbal Cream
Authors: Chatur Vibhavari Makarand , Ansari Nazma M. , Joshi Sanket K. , Walode Sanjay G.
Published: August 2022

Cosmetics made from either natural or synthetic components are almost in regular use universally in many different forms for enhancing the beauty. Azadirachta indica and Nyctanthes arbor-tristis are medicinal plants; these plants are used traditionally from ancient years in various herbal medicinal systems such as Ayurvedic, Homeopathic and Siddha. The dried leaves of Azadirachta indica and dried leaves of Nyctanthes arbor-tristis have antibacterial, anti-inflammatory analgesic activity. The present research is focused on the formulation of polyherbal cream and their evaluation by using various evaluation parameters.

Keywords: Polyherbal cream, Neem, Night Jasmine, Fusion method, Almond oil.
Öğrencilerin Organ Bağışı Hakkındaki Düşüncelerinin Belirlendiği Fenomenolojik Bir Çalışma
Authors: OYUR ÇELİK Gülay , DALFİDAN Büşra
Published: August 2022

Amaç: Bu çalışma öğrencilerin organ bağışına ilişkin düşüncelerinin, izletilen organ bağışı temalı film ve videolardan etkilenip etkilenmediğini incelenmek amacıyla planlanmıştır.Materyal-metot: Çalışma tanımlayıcı tipte olup, nitel ve nicel araştırma teknikleri birlikte kullanılmıştır. Üç aşamalı olarak planlanmıştır. Çalışmaya dahil edilen toplam 21 hemşirelik öğrencisi 2 gruba bölünmüş ve her iki gruba da farklı 2 film ve aynı kamu spotları izletilmiştir. Öğrencilere organ nakliyle ilgili 2 film ve organ nakline özendirici 3 video (kamu spotu/reklam) izletilmiştir. Öğrencilerin organ bağışına ilişkin ve film/video sonrası düşünce değişikliklerini sorgulayan yarı yapılandırılmış soru formunda 19 soru bulunmaktadır. Çalışma sürecinde elde edilen veriler araştırmacılar tarafından manuel olarak transkript edilmiş, benzer veriler temalar çerçevesinde kodlanmıştır.Bulgular: Çalışmaya katılmaya gönüllü olan öğrencilerin yaş ortalaması 21,38±1,46 olup 15 (%71,4)’i kadındır. Her iki grubun da filmi/videoları izledikten sonraki görüşleri/söylemleri doğrultusunda 4 ana tema ve her ana temanın altında farklı alt temalar belirlenmiştir. Bu ana temalar “1.filmle ilgili çıkarımlar (sağlık politikaları, empati, sosyal medya, maddi yetersizlik algısı alt temaları)”, “2.filmle ilgili çıkarımlar (cesaretlendirme alt teması)”, “videolar/kamu spotları ile ilgili çıkarımlar (dini destek, organ bağışının başkaları için önemi, videoları teşvik edici-bilgilendirici bulma alt temaları)” ve “öğrenci önerileri”dir.Sonuç: Öğrencilerin çoğunluğu izledikleri filmleri ve videoları etkileyici bulmuştur. Videoların kısa olmasının organ bağışında daha etkili olabileceğini ifade etmişlerdir. Film/videolar, öğrencilerin organ bağışına ilişkin olumlu yöndeki görüşlerini pekiştirmiştir. Öğrenci görüşleri doğrultusunda oluşturulan temalarda “dini destek” alt teması ön plana çıkmıştır.
Grelin ve Grelin Reseptörü Polimorfizmlerinin Tip 2 Diyabetle İlişkisi
Authors: SELÇUK Esma , ŞAHİN Uğur , ÖZKAHRAMAN Didem , CALAPOĞLU Mustafa , ŞAHİN CALAPOĞLU Nilüfer
Published: August 2022

Bir gastrik peptit olan grelin ve onun büyüme hormonu salgılatıcı G protein-bağlı reseptörünün glukoz metabolizması ve enerji homeostazında önemli bir rol oynadığına dair ciddi kanıtlar mevcuttur. Bu nedenle, Tip 2 diyabet için duyarlılık alelleri taşıyan bu genler potansiyel birer aday olarak değerlendirilmektedir.
Isparta yöresinden 75 Tip 2 diyabet hastası ve 25 kontrolden oluşan 100 Türk yetişkin bireyin dahil edildiği vaka-kontrol kesitsel ilişkilendirme çalışması yapıldı. Grelin geninde dört promotör (rs26311, rs26312, rs27647, rs3755777) ve bir intronik (rs35683) bölge ve Grelin reseptöründe bir intronik (rs509035) ve bir 3'UTR (rs565105) bölge tek nükleotid polimorfizmleri seçilerek Tip 2 diyabet ile ilişkisi Matris Destekli Lazer Desorpsiyon/İyonizasyon Uçuş Süresi Kütle Spektrometresi sistemi kullanılarak araştırıldı.
Tip 2 diyabet ile iki adet tek nükleotid polimorfizmi arasında anlamlı bir ilişki saptandı: Grelin geninin promotör bölgesinde yer alan rs27647 ve intron 1'de bulunan rs35683 (P<0.05).
Sonuç olarak, elde edilen bulgular Isparta yöresinde yaşayan Tip 2 diyabet toplumunda grelin polimorfizmlerinin hastalık gelişimine yatkınlık oluşturabileceğini düşündürmektedir.
Faculty Competencies: An Exploration of Feasibility and Acceptance
Authors: Tulshian Priyanka , Gopal Bharat , Kenyon Tina
Published: August 2022

Introduction: A uniform method of iterative professional development for medical educators does not exist in the United States graduate medical education system. The Society of Teachers of Family Medicine Faculty Competencies Special Project Team, a subgroup of the Faculty Development Collaborative, sought to create a competency-based assessment framework for medical educators. This paper describes the feasibility and acceptance of a draft competencies resource using a survey.
Methods: A mixed-methods, ten-question survey to assess the feasibility and acceptance of the draft competencies resource was created and distributed to medical educators through educational contacts from October 2019 to November 2019.
Results: Eighty-six surveys were completed. Of the 86 respondents, 48 (55%) answered all the survey questions. Thematic analysis for acceptance of the draft yielded three groups, the accepting, neutral, and nonacceptance groups. Each group had distinct characteristics regarding the likelihood of accepting and using the draft competencies.
Conclusions: The draft competencies are thought to be feasible, with overall acceptance in the current form. Further research will guide revisions of the competency resource before final distribution.
Patient and caregiver perceptions of airway clearance methods used for cystic fibrosis
Authors: Fischer Anthony , Kienenberger Zoe , Farber Tyler O. , Teresi Mary E. , Milavetz Francesca , Singh Sachinkumar , Larson-Ode Katie , Thoma Theodosia , Weiner Rebecca , Burlage Kathryn R.
Published: August 2022

Introduction: Cystic Fibrosis Foundation guidelines recommend
people with CF perform daily airway clearance. This can be difficult for
patients to complete, as some find it time consuming or uncomfortable.
Data comparing airway clearance methods are limited. We surveyed
patients and families to understand which methods are preferred and
identify obstacles performing airway clearance. Methods: We
designed a REDCap survey and enrolled participants in 2021. Respondents
reported information on airway clearance usage, time commitment, and
medication use. They rated airway clearance methods for effectiveness,
comfort, time commitment, importance, and compatibility with other
treatments. Analysis included descriptive statistics and clustering.
Results: 60 respondents started and 52 completed the survey.
The median patient age was 20 years. Respondents experienced a median of
four airway clearance methods in their lifetime, including chest wall
oscillation (vest, 92%), manual chest physical therapy (CPT, 88%),
huff coughing (77%), and exercise (75%). Past 30-day use was highest
for exercise (62%) and vest (57%). Time commitment was generally less
than 2 hours daily. Of those eligible for CFTR modulators, 53% reported
decreased time commitment to airway clearance after starting treatment.
On a scale of 0-100, respondents rated CFTR modulators as their most
important treatment (median 99.5), followed by exercise (88).
Discussion: Patients and caregivers are familiar with several
methods of airway clearance for CF. They report distinct strengths and
limitations of each method. Exercise and vest are the most common
methods of airway clearance. Use of CFTR modulators may reduce
patient-reported time commitment to airway clearance.
Transcatheter ventricular septal defect closure via femoral vein alone under transthoracic echocardiography guidance without fluoroscopy: preliminary experience
Authors: Huang LiuLiu , Chen Mai , Zeng Decai , Su Chun Xiao , Jiang Chun Lan , Zheng Bao Shi , Wu Ji
Published: August 2022

Objective. Transcatheter closure of congenital ventricular
septal defects under echocardiography guidance could avoid potential
radiation damage from fluoroscopy probes. However, mini-surgical
incision, transesophageal echocardiography combined with tracheal
intubation, and limited artery access further complicate the procedure.
Therefore, we aimed to describe our preliminary experiences in
percutaneous VSD closure via the femoral vein only under transthoracic
echocardiography (TTE) guidance. Methods. Between December 2018
and November 2021, 19 patients underwent transcatheter VSD closure via
femoral vein alone under the guidance of TTE in our hospital. The
morphology, location, diameter of VSD, and procedural outcomes were
thoroughly reviewed. Symmetric, asymmetric, or eccentric occlusion
device was chosen for closure based on the VSD characteristics.
Results. There were 16 perimembranous VSD and 3 intracristal
VSD patients in this cohort. The range of diameter of the VSD was from
3.8 to 7.4 mm. Fifteen symmetrical occluders were implanted in 13
perimembranous and 2 intracristal VSD patients. Two eccentric occluders
were implanted in 1 perimembranous and 1 intracristal VSD patient since
the rim to the aortic valve distance was <2 mm. Moreover, 2
asymmetrical occluders were used in 2 perimembranous multi-hole VSDs.
Immediate procedure and 16.1±9.9 months’ follow-up outcomes showed no
device dislodgement and embolism, no new-onset aortic valve
regurgitation, and no atrioventricular heart block.
Conclusions. Transcatheter perimembranous and intracristal VSD
closure via femoral vein alone under the TTE guidance is feasible and
safe in eligible patients. The new type of multipurpose specialized
catheter will facilitate this procedure.
Pyogenic Granuloma of the Gingiva: A Case with Severe Bone Loss
Authors: Aoun Georges
Published: August 2022

Pyogenic granuloma (PG) is an inflammatory hyperplasia that arises in
response to various stimuli such as low-grade local irritation,
traumatic injury, or hormonal factors. It may occur at any age, with the
highest incidence in the 2 and 5
decades of life. Women are more frequently affected due to the increased
levels of circulating hormones, oestrogen and progesterone. The most
common site for oral PG is the gingiva. In this report, a case of PG of
the gingiva with severe bone loss is presented.
PENANAMAN NILAI-NILAI PERDAMAIAN DI PEACESANTREN WELAS ASIH SAMARANG GARUT
Authors: Dewi Azhar Rosa Kusuma , Bashori Khoiruddin , Samsuddin Muhammad
Published: August 2022

This study aims to determine the achievements, models, and methods of inculcating the values of peace in Peacesantren Welas Asih Garut. The formation of values as the core of the goals of national education cannot be achieved instantly. It takes efforts to find alternative educational models that can be applied. Peace education is an effort made to realize values, behavior, and ways of life that support the creation of a culture of peace. This study used a qualitative approach with analytic descriptive data analysis. Data analysis techniques include data collection, data reduction, data presentation, and drawing conclusions. The result of this research is the inculcation of the values of peace is included in the learning curriculum by teaching 12 values of peace. The achievements are to form the character of the santri (student) who is empathetic, independent, and courageous, capable of being a problem solver, critical, creative, communicative, and collaborative, as well as becoming a peacemaker and changemaker. The factor that supports the achievements of the inculcation of the values of peace is the Peacesantren Welas Asih that pays close attention to the quality of their abah ambu (teachers/coaches) to upgrade their knowledge and skills with the activities of Welas Asih Abah Ambu Academy (WAAAA) and collaborative parenting as a form of collaboration between schools and parents in educating students with Welas Asih Abah Ambu Academy (WAABA) activities. Basic peace value material is given during the orientation period of students with the name Welas Asih untuk Semesta (Compassion for the Universe). In this program, students and parents must be committed to supporting the implementation of anti-bullying policies and culture. Life skills-based education is applied in Peacesantren Welas Asih with an emphasis on 21’st century skills, namely literacy, competence, and character. The guidance follows 3 Guidance Pillars, namely, positive discipline, reflective relationship, and effective learning using the Project-based Learning, Problem-based Learning, and Discovery Learning models using the Design For Change method, with the FIDS (Feel, Imagine, Do and Share) learning system.
EVENT MARKETING TOKOPEDIA WIB TV SHOW X BTS ON PURCHASE INTENTION OF INDOMILK MILK PRODUCT, BANANA VARIANT
Authors: Budimansyah Muhammad Rizki , Widodo Arry
Published: August 2022

This research is motivated by the occurrence of the Covid-19 pandemic in Indonesia and the very rapid development of the Hallyu phenomenon during the quarantine period at home and the PSBB which is used by e-commerce to carry out promotional activities. The Covid-19 pandemic has made almost all business activities in Indonesia have a bad impact until bankruptcy. This forces companies to be able to find ways to survive during the pandemic and also compete with competitors.This study aims to determine and analyze the effect of the Tokopedia WIB BTV Show X BTS marketing event on the purchase intention of the Banana Flavored Indomilk Dairy Product. The method used is quantitative with the aim of causality research and the SEM-PLS analysis method. The sampling technique used is non-probability sampling with a total of 385 people throughout Indonesia who know and have seen the Tokopedia WIB TV Show marketing event. Based on the research hypothesis testing, it is concluded that event marketing directly has a positive and significant effect on buying interest.
THE INFLUENCE OF ADVERTISING, DIRECT MARKETING AND EVENT EXPERIENCE ON BRAND AWARENESS AND THEIR IMPACT ON PURCHASE DECISION
Authors: Prayudi Dicki , Nugraha Rusli
Published: August 2022

The new model of business selling dried flower in Sukabumi has become an interesting research object to test its marketing variables. In this study, the variables used to determine the extent to which the Brand Awareness variable is formed from the Advertising variable, the direct marketing variable and the Event & Experience variable, impacted on purchasing decisions. The method used is descriptive quantitative. The model was analyzed by structural equation modeling (Structural Equation Modeling) based on components or variants (component bases) which is popular with Partial Least Square (PLS). The results show that the three variables tested significantly affect Brand Awareness, namely the Total Effect value of 0.028 for Advertising, 0.096 for Direct Marketing, and 0.0558 for Event & Experience. The conclusion in this study describes the variables that strongly support the creation of Brand Awareness in a product between Advertising, Direct Marketing and Ecent & Experience; a strengthened Event & Experience has a significant influence
DETERMINANTS OF INDONESIAN BANKING PROFITABILITY
Authors: Khalifaturofi'ah Sholikha Oktavi , Ulum Achmad Saiful
Published: August 2022

This study aims to investigate determinants of Indonesian banking profitability. The determinants of banking profitability are bank specifics and macroeconomic indicators. This study uses balanced panel data involving 18 banks in Indonesia for the period 2009-2019. The research method used is panel regression method. Empirical findings indicate that bank specifics, such as bank liquidity and capital, have a positive and significant effect on banking profitability, while the cost-to-income ratio and leverage has a negative and significant effect on banking profitability. The results of this study have considerable implications for policy. The government needs to regulate inflation, exchange rates, and interest rates. The results of this study can help policy makers, governments, bankers, and bank managers to better understand the various determinants of bank profitability.
EFFECT OF FINANCIAL LITERACY, FINANCIAL ATTITUDE, AND FINANCIAL INCLUSION ON FINANCIAL BEHAVIOR
Authors: Sukma Sjahmagri Priatama , Pradana Mahir
Published: August 2022

Students who are financially dependent on parents and financial-independent students are affected by Covid-19. Preventing financial problems can be carried out by good financial literacy. Based on precedent studies, financial literacy in Telkom University students was good; however, in reality, a protest emerged regarding tuition fees, generating a gap between the theory and reality. This study aimed to test a financial literacy argument of Telkom University students and the reality during pandemic. The study employed a quantitative method, verificative description, and purposive non-probability sampling technique. The study respondents amounted to 100 students of Business Administration undergraduate study. Data were analyzed using path analysis. From the hypothesis testing results, the financial literacy variable affected financial attitude, financial inclusion, and financial behavior. The inclusion variable affected and mediated the effect of financial literacy on financial behavior. Meanwhile, financial attitude did not affect and mediate the effect of financial literacy on financial behavior.

 

Keywords: Financial; Financial Literacy, Financial Attitude; Financial Inclusion; Financial Behavior; Students
QUALITY OF INVESTMENT DECISION, BUSINESS RISK, EFFICIENCY AND PROFIT GROWTH
Authors: Giovanni Axel , Sijabat Yacobo P. , Hirawati Heni , Jauzaa Alifa
Published: August 2022

Earnings growth is an indicator that shows the company's capability to increase net profit in a certain period compared to the previous period. This study aims to provide empirical evidence regarding the role of investment decision quality, business risk, and efficiency on corporate earnings growth. The research population includes all companies in the property, real estate and building construction sectors. The research sample was 50 companies which were obtained through purposive sampling method. This research uses linear regression analysis method. The results provide evidence that the quality of investment decisions, business risk and efficiency have a significant role in the earnings growth of the company in the property, real estate and building construction sectors.
THE EFFECT OF FINANCIAL RATIOS IN PREDICTING FINANCIAL DISTRESS IN MANUFACTURING COMPANIES
Authors: Arifiana Risa , Khalifaturofi'ah Sholikha Oktavi
Published: August 2022

The purpose of this study is to analyze the effect of financial ratios in predicting financial distress in manufacturing companies. The sampling technique used in this study is purposive sampling. The research sample is 87 manufacturing companies listed on the Indonesia Stock Exchange (BEI) for the 2016-2020 period. The data analysis technique is logistic regression. The results show that profitability and activity ratio have a negative and significant effect on predicting financial distress. In addition, the liquidity and leverage ratio have no significant effect on predicting Financial Distress. The implication of this study is manufacturing companies have to increase profitability and activity in order to avoid financial distress.
THE INFLUENCE OF BRAND LOVE ON BRAND LOYALTY ON H&M GLOBAL FASHION BRANDS IN JAKARTA
Authors: Arsj Febri Rakhmawati
Published: August 2022

This study was conducted to observe and test brand love against brand loyalty at the global fashion brand H & M in Jakarta. This research is descriptive quantitative research by distributing questionnaires through the google form platform which is distributed to 115 respondents who live in the city of Jakarta and have made purchases at least twice. The results of this study were analyzed through validity test, reliability test and T test using SPSS as an analytical tool. This study reveals that the brand love variable has a significant positive effect on brand loyalty as seen by the t-count value of 4.431 > 1.984 and a significant value of 0.000 < 0.05. The higher the brand love will be able to increase the intensity of consumers loyal to the brand. the contribution made, namely, H & M is expected to be able to maintain and strengthen brand love (love of brands). This will create intensity that consumers will make regular repeat purchases and will promote them to a wide audience.
Miten luonnon monimuotoisuudesta ja sen uhista puhutaan yleistajuisissa asiantuntijateksteissä?
Authors: Lahti Emmi
Published: August 2022

Artikkelissa tarkastellaan sitä, millainen kuva luonnon monimuotoisuudesta rakentuu ja miten monimuotoisuuden uhista puhutaan erilaisissa yleistajuisissa asiantuntijateksteissä. Aineistona on blogi- ja uutistekstejä maa- ja metsätalousministeriön, Luonnonvarakeskuksen ja luonnonsuojelujärjestöjen verkkosivuilta. Tutkimus on kielitieteellistä diskurssianalyysia, ja sen kehyksenä on ekolingvistiikka. Analyysista käy ilmi, että etenkin ministeriön ja Luonnonvarakeskuksen teksteissä monimuotoisuuden käsite jää usein epämääräiseksi ja abstraktiksi, eikä aina ole selvää, mihin sillä viitataan. Luonnonsuojelujärjestöjen teksteissä käsitettä selitetään enemmän ja monimuotoisuuden edistämiseen tähtäävistä toimista puhutaan konkreettisemmin. Tällöinkin kuitenkin luonnon monimuotoisuus näyttää viittaavaan usein melko suppeasti vain lajien runsauteen. Kaikkien toimijoiden teksteissä rakentuu kuva siitä, että monimuotoisuus on tärkeää. Monimuotoisuutta uhkaavista ja heikentävistä toimista ja prosesseista puhutaan tyypillisesti käyttämällä nominaalistuksia ja passiivia, jolloin ihmisen rooli ei tule eksplisiittisesti esiin. Kun ihminen mainitaan, puhutaan ihmisistä kollektiivisena yksikkönä, jolloin vastuu- ja valtasuhteiden käsittelystä tulee mahdotonta. Yhtenä luonnon monimuotoisuutta uhkaavana asiana mainitaan vieraslajit, joiden torjunnassa ihmiselle rakentuu aktiivinen rooli.