bluuebunny/crossref_metadata_2025 huggingface dataset:
Algorithms . . . Alcatraz: Are children prisoners of process?
Authors: Hurst Chris
Published: August 2023

Multiplicative thinking is a critical component of mathematics which largely determines the extent to which people develop mathematical understanding beyond middle primary years. We contend that there are several major issues, one being that much teaching about multiplicative ideas is focussed on algorithms and procedures. An associated issue is the extent to which algorithms are taught without the necessary explicit connections to key mathematical ideas. This article explores the extent to which some primary students use the algorithm as a preferred choice of method and whether they can recognise and use alternative ways of calculating answers. We also consider the extent to which the students understand ideas that underpin algorithms. Our findings suggest that most students in the sample are â€˜prisoners to procedures and processes' irrespective of whether or not they understand the mathematics behind the algorithms.
Conceptual and procedural angle knowledge: do gender and grade level make a difference?
Authors: Aydın Utkun
Published: August 2023

The study examined differences in students' conceptual and procedural knowledge of angles among two grades and gender. Participants were 382 sixth and 376 seventh graders from a metropolitan city in [Country]. [Nation] students' conceptual and procedural knowledge of angles declined from sixth to seventh grade. Gender differences were found for procedural knowledge, but not for conceptual knowledge. Since conceptual and procedural knowledge of angles may have significant influences on the essential subsequent topics in geometry, we need to seriously consider the implications of these gender- and grade-related differences and pay attention particularly to males in Grade 7. The patterns of [Nation] students' conceptual and procedural angle knowledge were discussed, and educational implications were offered.
Problem Solving Trajectories in a Dynamic Mathematics Environment: The Geometer's Sketchpad
Authors: Bosse Michael J.
Published: August 2023

Student problem solving in the context of a dynamic mathematics environment (DME) has previously been investigated primarily through the lens of whether or not the student could complete a problem solving task. Herein, we investigate what trajectories students employ in the realms of mathematics, technology, and problem solving as they attempt to complete tasks and which of these trajectories are more helpful than others. Notably, it was determined that these trajectories are idiosyncratic, nonlinear, and iterative and that, while some trajectories help problem solving, others harm the problem solving process. Among other findings, it was determined that student access to technology may not assist their mathematical problem solving and may at times hinder it even further.
Pedagogical entrepreneurship in school mathematics: an approach for students' development of mathematical literacy
Authors: Haara Frode Olav
Published: August 2023

Emphasis on the development of the inner qualities thought to make up pedagogical entrepreneurship and use of such entrepreneurship as a strategy in mathematics teaching and learning could be expected to strengthen students' development of mathematical literacy. This is because problem solving, local cultures and resources, authenticity and action competence are key elements in the development of mathematical literacy and in pedagogical entrepreneurship in mathematics. A foundation for research on an alternative mathematics teaching approach for future decades is suggested based on the relationship between pedagogical entrepreneurship in mathematics and mathematical literacy in the literature and on the description of the contexts and teacher experiences of two best practice examples from the mathematics classroom. Emphasis on pedagogical entrepreneurship in school mathematics through problem solving and authenticity in a learning environment that applauds such approaches to learning of mathematics should be recognized as giving priority to the development of disciplinary literacy in mathematics.
Troy III-V
Authors: Easton Donald , Weninger Bernhard
Published: August 2023

To investigate the dating of Troy III-V, and in particular to test whether in Blegen's Troy sequence a gap exists between Troy III and Troy IV, 26 bone samples covering Troy III to VIa from the University of Cincinnati excavations were submitted for 14C-AMS analysis. Excluding outliers, they yield dates that are consistent with a chronological scheme which includes a 110±20 year gap after Troy III, with Troy IV beginning 2060±10 cal BC. The hypothesis of a Proto-IV period which might bridge the gap, featuring deposits known only from the more recent excavations, can therefore be entertained.
Effect of pregnancy-specific β1-glycoprotein on the expression of arginase-1 and indolamine-2,3-dioxygenase by myeloid-derived suppressor cells
Authors: Timganova Valeria P. , Shardina Kseniya Y. , Gutina Evgenia V.
Published: August 2023

Myeloid-derived suppressor cells (MDSC) - a population of immature cells of myeloid origin with inhibitory functions, mainly related to T lymphocytes. Normally, MDSC account for less than 1% of leukocytes in peripheral blood. The number of these cells increases during healthy pregnancy. However, MDSC have been shown to play a critical role in the maintenance of tumor growth and in autoimmune diseases.
Because MDSC are now considered important regulators of immunity, finding ways to manipulate their functions is important for the development of therapies for malignant and autoimmune diseases, as well as for pregnancy pathologies and post-transplant complications. The immunosuppressive mechanisms of these cells are mediated by their expression of the surface molecules CD73, ADAM17, PD -L1, the enzymes arginase 1 (Arg 1), inducible nitric oxide synthase (iNOS), and indoleamine 2,3-dioxygenase (IDO), reactive oxygen species, and the production of the anti-inflammatory cytokines IL -10 and TGF-1.
Pregnancy-specific 1-glycoprotein (PSG) is a pregnancy glycoprotein that has immunomodulatory effects on natural (dendritic cells and macrophages) and adaptive (T cells) immunity cells. At the same time, the effect of PSG on MDSC has not been investigated so far. Since this glycoprotein has promising pharmacological applications, it is necessary to study not only the native variant of PSG but also its recombinant form.
Since the main function of MDSC is immunosuppression, the aim of our work was to evaluate one of its mechanisms, namely the intracellular expression of amino acid degradation enzymes Arg1 and IDO under the influence of native and recombinant PSG in vitro.
MDSC differentiation was performed from CD11b+ cells isolated from peripheral blood of healthy volunteers. Cells were cultured for 7 days with stepwise addition of GM-CSF, IL -1, and LPS. Native (n) (1, 10, and 100 g/mL) and recombinant (r) (1 and 10 g/mL) PSG was added to the cultures three days before the end of incubation. The percentage of MDSCs (Lin- HLA-DR -CD11b+CD33+) intracellularly expressing Arg1 and IDO was determined by flow cytometry.
It was found that nPSG and rPSG did not alter the amount of Arg1-expressing MDSCs at all concentrations examined. However, at a concentration of 10 g/mL, both types of proteins caused a statistically significant increase in the percentage of cells expressing IDO.
We have already established that nPSG and rPSG affect MDSC differentiation by increasing the proportion of these cells belonging to the monocytic subpopulation. However, now we can say that PSG, in addition, enhances the suppressive function of the studied cells.
The obtained data are novel and open perspectives for targeting myeloid suppressor cells to improve cellular technologies in science and medicine.
The effectiveness of immunomodulatory therapy with a synthetic analogue of the active center of the hormone thymus thymopoietin in the complex treatment of immunocompromised women with chronic infectious and inflammatory diseases of the pelvic organs
Authors: Kovaleva Svetlana V. , Nesterova Irina V. , Pikturno Svetlana N. , Chudilova Galina A. , Lomtatidze Lyudmila V. , Teterin Yuri V. , Pirogova Anna I. , Prosolypova Natalia S. , Chulkova Аlla M.
Published: August 2023

Chronic inflammatory diseases of the pelvic organs (pelvic inflammatory disease, PID) in women is among the main understudied problems in gynecology worldwide with adverse medical and socio-economic consequences, thus justifying the need for further study of immunopathogenesis and development of new approaches to treatment. Our objective was to develop new immunotherapeutic approaches to correction of combined disorders of the immune system functioning in immunocompromised women with PID and to evaluate their clinical and immunological efficacy.
55 women aged 20-40 years were examined, i.e., 35 patients with exacerbation of sluggish or recurrent PID, resistant to conventional therapy. Testiung was performed before complex treatment (study group 1 GI- 1) and after the course (study group 2 GI-2). Contents of T and B lymphocytes, natural killer cells (NK) (CYTOMICS FC500, USA), phagocytic and microbicidal functions of neutrophilic granulocytes (NG) were assessed in SG-1 and SG-2 before and 2-3 days after complex treatment with addition of an immunotherapeutic drug based on hexapeptide (HP) at a daily dose of 45 mg/ml intramuscularly for 10 days.
In patients from SG-1, a decrease in T cells (CD3+CD19- ) and B cells (CD3-CD19+), a 2-fold increase in the content of NK CD3-CD16+CD56+ was found, along with altered functioning of NG (deficiency of actively phagocytizing NG, a decrease in their digestive function and NADPH-oxidase activity). In SG-2 patients, the treatment was followed by restoration of the T (CD3+CD19-) and B cells (CD3-CD19+), NK cells (CD3-CD16+CD56+), like as an increase in effector functions, i.e., microbial capture by NG and their killing ability due to activation of NADPH oxidases and normalization of microbicidal reserve capacity in the NG cell population. Positive clinical effect included reduction of clinical symptoms in acute period, absence of PID exacerbations over follow-up for 6 months (85.6% of cases). Occasional exacerbations of PID were associated with medical manipulations (5.7%) and unprotected sexual contacts (5.7%).
The immunopathogenetically proven approach to correction of combined functional impairment of immune system in the women with PID shows a positive clinical and immunological effect.
Content of myeloid-derived suppressor cells in autoimmune diseases in children
Authors: Radygina Tatiana V. , Kuptsova Daria G. , Petrichuk Svetlana V. , Potapov Alexander S. , Murashkin Nikolay N. , Abdullaeva Luizat М. , Kurbatova Olga V. , Tsvetkova Valeriya S.
Published: August 2023

Myeloid-derived suppressor cells (MDSCs) play an important role in regulation of immune response. An increase in their number in adult patients with autoimmune diseases has been reported. G-MDSCs, M-MDSCs, and MDSCs(M-G-) at different stages of autoimmune disease may both activate T cell proliferation, leading to disease progression, or inhibit it, thus promoting Treg differentiation. Arginase-1 (Arg- 1) is an enzyme in MDSCs that reduces the concentration of arginine required for T lymphocyte proliferation. Our aim was to evaluate the content of MDSCs populations and functional activity of MDSCs in children with autoimmune diseases. 75 children with inflammatory bowel diseases (IBD), 60 children with multiple sclerosis (MS), 69 children with psoriasis (PS), 62 healthy age-matched children were included into the study. The content of MDSCs ((CD3, CD19, CD56, HLA-DR)-, CD11b+ and CD33+), subpopulations of MDSCs (M-MDSCs, G-MDSCs expressing CD14 and CD15), assessment of Arg-1 activity were performed by flow cytometry techniques. The content of MDSCs in patients with IBD, MS and PS was significantly higher than in the comparison group and depended on the state of exacerbation/remission. In exacerbation and remission of IBD, MS and PS, a significant increase of MDSCs was revealed when compared with healthy children; the highest values were found in children in exacerbation of MS (Me-3.5 (2.5-5.6) % MNC against Me-1.6 (0.9-2.5) % MNC, p 0.001). In patients with MS, the content of G-MDSC, M-MDSC was significantly higher, and MDSC(M-G-) was lower than in healthy children. An increase in absolute amounts of G-MDSCs was shown in MS exacerbation compared to the disease remission state (p = 0.022). For patients with IBD, a significant increase in percentage of MDSCs and M-MDSCs (p = 0.014 and p = 0.045, respectively) was obtained in exacerbation of the disease relative to remission state. In patients with IBD, MS, and PS, a significant increase in Arg-1 activity in MDSCs was found, with a decreased number of MDSCs in patients in remission compared to exacerbation phase of the disease. In children with autoimmune diseases, an increase in the MDSC populations was found. The activity of arginase-1 in MDSCs is increased in remission, along with a decrease in their numbers.
Characteristics of the phagocyte effector indexes and effect of local cytokine therapy on their parameters in inflammatory diseases of the maxillofacial region
Authors: Latyushina Larisa S. , Malysheva Lyudmila Yu. , Piotrovich Albina V. , Berezhnaya Elena S. , Lapteva Anastasia V.
Published: August 2023

Odontogenic inflammatory diseases and injuries take a leading place in the structure of surgical dental pathology. They often proceed with inflammatory complications. The aim of the present work was to analyze the effector indexes of phagocytic cells at the local area of inflammation (secretions from purulent wounds, tooth socket and mixed saliva), and to evaluate the effect of topical cytokine therapy on the studied parameters in patients with inflammatory dental diseases (chronic periodontitis, odontogenic phlegmon) complicated by mandibular fractures. As a part of a two-stage research, 236 people were comprehensively examined, divided into groups depending on their clinical disease and method of treatment. This group included 74 patients (classified as K 04.5 K 04.9), divided into subgroups by the types of periodontitis (chronic fibrous, granulating and granulomatous form); 102 patients with phlegmon (classified as L03.2, K12.2), who, at the second stage of basic therapy, received topical cytokine treatment with betaleukin (recombinant IL- 1) and roncoleukin (recombinant IL-2). Fifty patients with fractures of the lower jaw (classified as S 02.6) underwent immunotherapy with betaleukin at the second stage of treatment. Examination of patients with inflammatory dental diseases at the first stage of study and analysis of the effector indexes of neutrophilic granulocytes and macrophages from the local inflammatory foci revealed some immunological predictive signs of lacking efficiency of the inflammatory response, manifesting as aberrant functional activity of phagocytes, e.g., inhibition of all studied parameters along with sufficiently reduced functional reserve of phagocytic cells in the patients with phlegmon; high ability to produce reactive oxygen species with a decreased functional reserve of neutrophils in the patients with fractures, and signs of activated chronic inflammation in the patients with periapical lesions. The second stage of our research associated with topical therapy with recombinant cytokines and analysis of the obtained data, ebabled us to detect different effects of drugs on the studied parameters and register the integral effect of immunotherapy, which represents normalization of altered functional indexes. Hence, the data obtained may indicate that, in patients with inflammatory processes in the maxillofacial region, a higher adaptive effector potential of phagocytes was formed at the affected focus following the topical cytokine therapy.
Dynamics of matrix metalloproteinases and their tissue inhibitors in patients with herpesvirus and papillomavirus infection
Authors: Nevezhkina Tatiana A. , Chernikova Maria A. , Markelova Elena V. , Tulupova Marina S. , Kostyshko Anna V. , Fedyanina Lydmila N. , Markova Natalia Yu.
Published: August 2023

Sexually transmitted infections are of great importance for the proper reproductive function in women. Chronic inflammatory process leads to reproductive disorders. A special role in the chronic inflammatory process is attributed to papillomavirus (PVI) and herpetic infection. MMP-2 and MMP-9 enzymes cleave type 4 collagen which makes the scaffold of basement membranes and contributes to the separation of endothelial cells from the membranes, followed by their further migration and direct participation in angiogenesis thus affecting the growth of tumors, in particular cervical cancer. Tissue inhibitors of matrix metalloproteinases are known to limit the collagen breakdown. However, the imbalance of MMP and TIMP is accompanied by accumulation of extracellular matrix and increased risk for reproductive disorders. The aim of our study was to evaluate the dynamics of acute-phase proteins affecting the state of intercellular matrix (MMP-2, MMP-9 and MMP tissue inhibitors (type 1, 2) in blood serum of patients with PVI or coinfection of PVI and HSV before and after therapy with drugs exhibiting antiviral and immunomodulatory effects, i.e., a synthetic compound (Inosine pranobex) and vegetable substance (Solanum tuberosum). We have examined 141 patients with papillomavirus and herpetic infections treated with Inosine pranobex and Solanum tuderosum. Determination of MMP-2, MMP-9 and TIMP-1, TIMP-2 levels of in blood serum was carried out using specific reagents from RD Diagnostics Inc. (USA). The drug therapy with active substances of Inosine pranobex and Solanum tuberosum was associated with positive dynamics of the level of MMP-2, MMP-9 and tissue inhibitors of types 1 and 2 in all groups under studies. However, Inosine Pranobex exerts more pronounced changes, especially in subgroups with viral coinfections.
Indicators of immunological response to non-drug therapy of chronic adenoiditis
Authors: Solodovnic Anna V. , Vyalova Tamara A. , Gabova Ekaterina V. , Pozdnyakov Pavel A. , Bushueva Daria S.
Published: August 2023

The aim of our work was to study individual indices of immune response in children with chronic adenoiditis and evaluate their dynamics following low-frequency ultrasonic cavitation combined with photochromotherapy included into the treatment regimen. The study involved 104 patients 3 to 15 years old, divided into three groups: the 1st control group (n = 34) received standard treatment for 7 days; 2nd group (n = 37) received a supplementary low-frequency ultrasonic cavitation irrigation of pharyngeal tonsil combined with photochromotherapy on lymphoid tissue of the pharyngeal tonsil for 7 days; the 3rd group (n = 33) received only low-frequency ultrasonic cavitation irrigation treatment. Comparative estimation of clinical and immunological indicators (sIgA, IL-1, IL-6, IL-8, IL-10, TNF) was performed prior to the therapy (day 0) and on the 7th day from the start of treatment. Before therapy, a decrease in the content of sIgA, IgA was revealed in all groups. In the second group, there was a statistically significant increase in the level of IgA after treatment, which suggests activation of local immunity factors. The dynamics of proinflammatory cytokines (IL-6, IL- 10) also indicates effectiveness of the drug treatment by reducing manifestations of the tissue immunological reactivity in pharyngeal tonsil. An increased number of anti-inflammatory IL-8 and IL- 10 cytokines could be considered a compensatory response to decreased level of proi-inflammatory cytokines.

As a result, the inclusion of low-frequency ultrasonic cavitation in combination with photochromotherapy into the complex treatment for chronic adenoiditis thus stabilizing the course of immune response.
Immunopharmacological aspects of studying immunotropic properties of a novel biocompound
Authors: Zabokritskiy Nikolay A.
Published: August 2023

The article presents an experimental study of immunotropic activity of a new compound, a metabiotic, based on metabolites (biologically active substances) produced by a of saprophytic Bacillus subtilis B-9909 strain, being safe for health and standardized at Russian National Collection of Industrial Microorganisms (RNCIM). The aim of our study was to experimentally evaluate the immunotropic effects of metabolites produced by the probiotic Bacillus subtilis B-9909 upon the parameters of cellular immunity tested in the animal model of induced toxic liver damage. The metabolites were isolated from the cultural liquid of Bacillus subtilis culture (RNCIM strain B-9909) during its deep cultivation in a medium containing hydrochloric acid hydrolyzate of soy flour, or pancreatic hydrolyzate of casein. At 16-18 hours of cultivation, the cells were in the exponential growth phase. The indices of cellular status were studied in experimental groups of animals, when assessing therapeutic efficacy of an experimental metabiotic sample, as compared to a group of laboratory animals treated with the reference drug (ursosan). We assessed the quantitative indicators of blood as follows: determination of phagocytic activity (FA) of peripheral blood neutrophils; measurement of metabolic activity in peripheral blood neutrophils by means of NBT-test; quantitative determination of T and B lymphocytes; the number of antibody-forming cells (AFC). Liver damage was studied in a model of acute toxic hepatitis in albino rats. Experimental toxic hepatitis was induced by 40% solution of CCl4 in vaseline oil injected intragastrically for 2 weeks at the dose of 0.2 g/kg. The results of experimental studies showed activation of phagocytic activity by peripheral blood neutrophils at the early terms of experiment, being also confirmed by the results of NBT-testing. Moreover, at the early observation terms, a significantly increased representation of T and B lymphocyte populations as well as AFC numbers, were revealed thus suggesting activation of all components of cellular immunity in response to the carbon tetrachloride toxicity. Thus, the reported studies on the cellular status of laboratory animals treated with metabolites produced by probiotic microorganisms of the genus Bacillus subtilis (B-9909) on laboratory animals with toxic liver damage allow us to conclude that the test sample of this metabiotic preparation exerts a significant immunomodulatory effect, when compared with ursosan. This evidence allows us to consider this compound a promising candidate drug for a new hepatoprotector with immunotropic effect.
Combined effect of methotrexate and bifidobacteria metabolites on TNFα AND IFNγ production by human peripheral blood mononuclears
Authors: Ivanova Elena V. , Chaynikova Irina N. , Bekpergenova Anastasia V. , Bondarenko Taisiya A. , Chelpachenko Olga E. , Zdvizhkova Irina A. , Perunova Natalya B. , Bukharin Oleg V.
Published: August 2023

Methotrexate (Mtx) is a first-line drug for the treatment of numerous rheumatic and non-rheumatic disorders, including oncological disdiseases. However, therapeutic efficacy of Mtx is limited by severe toxicity to many organs (myelo-, hepato-, nephrotoxicity, mucositis, enteritis, dysbiosis at various human biotopes, etc.). Recently, a number of studies showed that some metabolites of Bifidobacteria and Lactobacilli are able to enhance effect of chemotherapeutic drugs and limit their toxic properties. The aim of the present work was to study the possible potentiating action of Bifidobacteria cell-free supernatants and methotrexate upon secretion of pro-inflammatory TNF and IFN cytokines by human peripheral blood mononuclear cells (PBMCs). The immunoregulatory effects upon production of TNF and IFNg was evaluated in the in vitro model of cultured PBMC supplemented with Bifidobacteria metabolites, methotrexate, or their combination. Analysis of the combined effect of Bifidobacteria metabolites and Mtx on the cytokine production revealed their synergism towards the key pro-inflammatory cytokines (TNF and IFN). We found an increase against the control cultures (with Mtx only), inhibition of the early pro-inflammatory cytokine TNF production. On the contrary, we revealed an increased secretion of IFN which regulates the effector cells. The results obtained with these cytokines suggest the presence of a potentiating effect of Bifidobacteria metabolites upon anti-inflammatory and immunoregulatory properties of methotrexate. Thus, Bifidobacteria metabolites can be considered a promising agent which potentiates the therapeutic action of methotrexate by suppressing TNF secretion and stimulating IFN by immunocompetent cells. Further studies of the combined effects of Mtx and metabolites from the intestinal microbiota upon the cytokine production by effector cells could be recommended, aiming to enhance therapeutic effect of methotrexate and limit its toxic properties using the Bifidobacteria metabolites.
Study of oxidative phosphorylation and glycolysis in CD4+T lymphocytes of HIV/HCV coinfected immunological non-responders by means of the seahorse technology
Authors: Korolevskaya Larisa B. , Vlasova Violetta V. , Shmagel Nadezhda G. , Saidakova Evgeniya V.
Published: August 2023

Oxidative phosphorylation and glycolysis are essential for CD4+ T-lymphocyte survival, division, and functioning. However, indirect evidence suggests that in HIV-positive hepatitis C virus (HCV) coinfected immunological non-responders to antiretroviral therapy, the CD4+ T-cell metabolic activity parameters are violated. This information implies that in immunological non-responders, CD4+ T-lymphocytes' inability to productively divide and increase in number after viral suppression by antiretroviral drugs may be due to metabolic dysfunction. The newly released technology for the analysis of extracellular fluxes using seahorse XF equipment permits assessment of the cells metabolic activity. The aim of this study was to evaluate the efficiency of oxidative phosphorylation and glycolysis in CD4+ T-lymphocytes of HIV/HCV coinfected immunological non-responders using Seahorse technology. Peripheral blood samples from patients of two groups were studied: HIV/HCV coinfected immunological non-responders with CD4+ T-lymphocyte count less than 350/l and HIV/HCV coinfected immunological responders with CD4+ T-cell count more than 500/l. In isolated CD4+ T-lymphocytes, the basal and maximal oxygen consumption rates by complexes of the mitochondrial electron transport chain, as well as the rate of medium acidification by protons formed during glycolysis, were assessed. It has been established that in HIV/HCV coinfected immunological non-responders, both basal and maximal oxygen consumption rates by CD4+ T-cell mitochondria are reduced. Moreover, in isolated CD4+ T-lymphocytes of immunological non-responders, the basal rate of glycolysis is increased. It can be assumed that a significant part of CD4+ T-lymphocytes in HIV/HCV coinfected immunological non-responders is activated and ready for homeostatic proliferation, which aggravates the need for additional energy and macromolecules. However, cells are unable to change their metabolism in a coordinated manner to meet these demands. The identified dysregulation of metabolic pathways may contribute to the low regenerative capacity of CD4+ T-lymphocytes in HIV/HCV coinfected immunological non-responders.
Studies on the hormone and cytokine producing function of human cumulus cells and its interrelation with fertility in polycystic ovarian syndrome
Authors: Valikova Olga V. , Zdor Victoria V. , Tikhonov Yakov N. , Boroda Andrey Victorovich , Gracheva Alina M. , Kolbin Konstantin G.
Published: August 2023

Cumulus cells (CC) are the specialized layer of follicular cells that are in close contact with the oocyte. They are considered as indirect markers of the oocyte quality. Changes of these cells suggest a damage of the ovary. Determination of cytokines in cumulus cell culture may predict the chance for the conception and development of pregnancy. The objective of the present study was to obtain a primary culture of CC from healthy donors and patients with polycystic ovarian syndrome (PCOS), to identify the most significant differences in production of key cytokines in the CC monocultures of patients and healthy individuals in order to predict the results of in vitro fertilization. Materials and methods: the cell culture technique was used, i.e., cumulus cells of healthy donors and patients with polycystic ovary syndrome were obtained by transvaginal puncture of follicles in the in vitro fertilization (IVF) program. This procedure does not affect the rights of embryo, since the CC are not used at the stage of IVF procedure and intracytoplasmic sperm injection (Ethical Committee Protocol No. 9 of May 16, 2022). IL-6, IL-10, IFN and progesteroneparameters were tested in adhesive cultures of CC by ELISA technique on days 1, 3, 7 of in vitro experiments. Results: We revealed a continuous secretion of progesterone, IL-6, IL-10, IFN in adhesive monocultures of CC. In the patients with PCOS, we have found a sharp increase of progesterone level in cultural media (p 0.01) on the 7th day, By contrast, the initially increased progesterone levels proved to be significantly decreased in donors on the 7th day of culture. Moreover, in the culture of CC from patients with PCOS (7th day of the experiment), the values of IL-6, IL-10 increased only two-fold compared with 30-fold increase of these cytokines in healthy donors (p 0.01). At the same term, we have observed a threefold decrease in IFN in the CC cultures of PCOS patients (p1-7 0.01; p 0.05) compared with cultured controls, which showed a 20-fold increase (p1-7 0.01), thus determining differences in total cytokine balance and, probably, influencing the pregnancy prognosis. Conclusion: Significant multidirectional changes of cytokine levels in the culture of cumulus cells of the patients with PCOS and in healthy individuals may be regarded as determining factors in formation of blastocyst and preservation of the embryo. A further in vitro research on the production of cytokines and sex steroids by CC is especially important on day 5 to 7, when the oocytes are selected for entry into the in vitro fertilization cycle. The study of morpho-functional properties of little-studied cumulus cells using the cell culture technique will enable us for a deeper study on the mechanisms of disturbed folliculogenesis in PCOS, and, thereby, improve the reproductive prognosis in this disorder.
Signifikansi Deklarasi Kuasa Sebelum Peristiwa Terangkatnya Yesus Ke Surga
Authors: Hasibuan Serepina Yoshika
Published: August 2023

Pertanyaan dasar dalam penelitian ini adalah bagaimana memahami signifikansi deklarasi kuasa dalam peristiwa menjelang kenaikan Yesus ke Surga? Apakah deklarasi kuasa ini hanya bersignifikansi pada gerakan misi atau sebenarnya menyangkut hal yang lebih luas lagi? Tujuan penelitian ini adalah meninjau lebih dalam tentang signifikansi pendeklarasian kuasa sesaat sebelum peristiwa terangkatnya Tuhan Yesus ke Sorga. Penafsiran umum seringkali mengaitkan pentingnya deklarasi kuasa ini dalam ranah pelaksanaan misi Amanat Agung. Penulis melalui artikel ini hendak menggali makna yang lebih dalam dari deklarasi kuasa baik dalam diri Tuhan Yesus, Allah Bapa maupun pemberian kuasa kepada para murid Yesus melalui analisis naratif sehingga dihasilkan tafsiran yang lebih komprehensif. Artikel ini diteliti dengan metode kualitatif menggunakan analisis naratif pada teks Matius 28:16-20 dan Kisah Para Rasul 1:6-11. Berdasarkan studi yang dilakukan maka ditemukan hasil bahwa signifikansi deklarasi kuasa bukan saja sebagai dorongan untuk pemberitaan Injil melainkan juga pada pembalikan paradigma tentang ke-Raja-an Yesus, persekutuan antar umat percaya, kemenangan atas kuasa setan, dan dasar terjadinya mukjizat.
Does Intellectual Capital Affect Financial Performance and Non-Performing Loans? Evidence From the Banking Sector in Turkey
Authors: PİLATİN Abdulmuttalip , AYAYDIN Hasan , BARUT Abdulkadir
Published: August 2023

The purpose of this study is to empirically examine the impact of intellectual capital (VAIC)
capacity of 21 Turkish banks on financial performance (ROA) and non-performing loans (NPL)
from 2004 to 2020. Panel data technique was used for analysis. The study results suggest that
banks’ intellectual capital is vital for their profitability, credit risk and competitive advantage. As
far as known, this is one of the first empirical researches in Turkey that examines the impact of IC
and its components on financial performance and non-performing loans of the Turkish banking
sector in the long term.
Effects of combined rice flour and molasses use on the growth performance of Pacific white shrimp (Litopenaeus vannamei Boone, 1931) applied biofloc technology
Authors: Phuong Ta V. , Hoa Nguyen V. , Diep Doan X. , Vo Van-Thanh , Nhu Ma B.
Published: August 2023

A 63-day completely random experiment with three replications was carried out to compare the effects of five different combination ratios of rice flour (R) and molasses (M) on the growth and survival rates of Pacific white shrimp (Litopenaeus vannamei Boone, 1931) postlarvae applied biofloc technology. Five biofloc (BF) treatments, including R90-M10, R70-M30, R50-M50, R30-M70, and R10-M90, formed with the addition of different combination ratios of rice flour and molasses, i.e., 90% R+10% M, 70% R+30% M, 50% R+50% M, 30% R+70% M, and 10% R+90% M, respectively, with C/N ratios of 15:1, and a control (neither rice flour nor molasses applied) was randomly arranged into the 18 plastic tanks of 1.0 m3 volume (with 0.5 m3 of water) each tank and salinity of 15‰. The postlarvae (0.095 g) were stocked into the tanks at a 150 ind. m−3 density and fed pelleted feed (40% protein). There was an improvement in growth (FMW, WG, DWG, and SGR) for all treatments. Besides, treatments with more than or equal to 30% molasses have improved SR, FCR, and FB. Especially the highest SR (94.2%) was obtained at the R70-M30, which perhaps created the highest FB (1.435 kg m−3) in this treatment. The lowest FCR (1.28) was also observed in the R70-M30 and significantly differed from the control and other treatments. Besides, water quality parameters were within the ranges recommended for Pacific white shrimp health during the experimental period. Our findings indicated the benefits of shrimp culture using the BF system when different combined ratios of rice flour and molasses were applied, of which a ratio of 70% rice flour and 30% molasses was considered as the best.
Hubungan Pengetahuan Ibu Terhadap Stunting Sebagai Upaya Peningkatan Pelayanan Kesehatan (Studi Pada: Kalurahan Caturharjo)
Authors: Fadlah Nur Ummi , Saharuddin Erni
Published: August 2023

Masalah stunting di Indonesia adalah ancaman serius yang perlu diperhatikan secara serius dan khusus. Dalam layanan kesehatan, kualitas dan keamanan semakin dipantau melalui pengumpulan indikator kualitas. Penelitian ini bertujuan untuk mengetahui hubungan hubungan pengetahuan ibu dengan kejadian stunting pada balita di kalurahan Caturharjo kabupaten Sleman dan menganalisis upaya meningkatkan pelayanan kesehatan sebagai strategi penurunan angka stunting yang dilakukan pemerintah di Kalurahan Caturharjo Kabupaten Sleman. Metode penelitian ini adalah penggabungan dua pendekatan penelitian kuantitatif dan kualitatif atau mixed methods dengan pendekatan cross sectional study. Populasi dalam penelitian ini yaitu ibu yang memiliki anak dibawah lima tahun berjumlah 80 orang. Hasil dari penelitian ini yaitu masingmasing variabel penelitian diketahui dari hasil analisis korelasi menggunakan uji chi-square (p < 0,05) menunjukkan bahwa ada hubungan antara antara kedua variabel (p = 0.004). Pelayanan kesehatannya cukup baik dengan prosedur pelayanan yang sistematis dengan waktu yang fleksibel.
AZ EMBERI ERŐFORRÁS ÉRTÉKELÉSE ÉS MEGJELENÉSE A VÁLLALATI VAGYONBAN
Authors: Dienes Angelika
Published: August 2023

A significant part of the value of a company is represented by intangible resources, which can be referred to under various names in the scientific literature (e.g. intellectual capital, intangible assets, knowledge capital, etc.). In the scope of the present study, the importance of valuing human resources and possible valuation methods are presented. Human resource accounting is mentioned in a number of academic works, but no unified definition has emerged for describing the term. The human value added model is also discussed, which provides the adjusted value of the company by adding the human assets to the assets side of the balance sheet and the human capital with the related future payment obligations of the employees to the liabilities side. Expert suggestions are also presented, according to which human assets should also be depreciated by means of a certain method or revalued at regular intervals. The provisions of the International Financial Reporting Standards (IFRS) are mentioned, as IFRS also regulate the recognition of future employee expenses and the recognition of internally generated intangible assets and intangible assets acquired in business combinations.
A invisibilização da população LGBTQIA+ no contexto pandêmico da covid-19: reflexões sobre biopolítica, necropolítica e interseccionalidade
Authors: Moraes Morgana Naiara Barbosa , Fernandes Luís Antonio Bitante
Published: August 2023

Sob a perspectiva dos conceitos de biopoder, biopolítica e necropolítica, enquanto dispositivos de poder, analisamos e descrevemos a invisibilidade de corpos abjetos no contexto da pandemia da covid-19, no Brasil. Após a criação de um diálogo entre os conceitos supracitados, aproximando-os ao pensamento decolonial, quanto à interseccionalidade entre raça, classe, gênero e sexualidade, analisamos dados relativos ao impacto da pandemia da covid-19 que foram fornecidos por duas organizações civis ligadas à proteção da população LGBTQIA+, pela ANTRA e pelo Coletivo #VoteLGBT. Demonstramos que esses dados denunciam as mazelas causadas pela pandemia e que a ausência de políticas públicas voltadas para a proteção dos corpos dessa população demonstra que o Estado brasileiro determina quem irá viver e quem irá morrer.

Palavras-chave: necropolítica; corpos abjetos; pandemia; sexualidade.

ABSTRACT

From the perspective of the concepts of biopower, biopolitics and necropolitics, as devices of power, we analyze and describe the invisibility of abject bodies in the context of the covid-19 pandemic in Brazil. After creating a dialogue between the aforementioned concepts, bringing them closer to decolonial thinking, regarding the intersectionality between race, class, gender and sexuality, we analyzed data on the impact of the covid-19 pandemic that were provided by two civil organizations linked to the protection of the LGBTQIA+ population, by ANTRA and the #VoteLGBT Collective. We demonstrate that these data denounce the ills caused by the pandemic and that the absence of public policies aimed at protecting the bodies of this population demonstrates that the Brazilian State determines who will live and who will die.

Keywords: necropolitics; abject bodies; pandemic; sexuality.

RESUMEN

Desde la perspectiva de los conceptos de biopoder, biopolítica y necropolítica, como dispositivos de poder, analizamos y describimos la invisibilidad de los cuerpos abyectos en el contexto de la pandemia de covid-19 en Brasil. Luego de crear un diálogo entre los conceptos antes mencionados, acercándolos al pensamiento decolonial, en cuanto a la interseccionalidad entre raza, clase, género y sexualidad, analizamos datos relacionados con el impacto de la pandemia del covid-19 que fueron proporcionados por dos organizaciones civiles vinculadas a la protección de la población LGBTQIA+, por ANTRA y el Colectivo #VoteLGBT. Demostramos que estos datos denuncian los males causados ​​por la pandemia y que la ausencia de políticas públicas destinadas a proteger los cuerpos de esta población demuestra que el Estado brasileño determina quién vivirá y quién morirá.

Palabras clave: necropolítica; cuerpos abyectos; pandemia; sexualidad.
O pessoal é político: reflexões sobre resistências lésbicas entre as montanhas de Minas Gerais durante os anos de 1970-1990
Authors: Souza Janice Aparecida de , Chacham Alessandra Sampaio
Published: August 2023

Neste artigo, partimos de relatos de vinte e uma lésbicas que viveram sua juventude entre os anos 1970 a 1990 em Belo Horizonte, a fim de refletir sobre suas possíveis contribuições para o avanço dos direitos LGBTQIAPN+, a partir das lentes da teoria feminista pós-estruturalista. Optamos por uma abordagem metodológica qualitativa, utilizando da técnica de entrevista em profundidade para traçar as histórias de vida dessas mulheres, buscando identificar suas diferentes formas de resistência, ao criarem espaços próprios de sociabilidade, ainda que segregados, em busca de amizade, amor, romance e sexo. Concluímos que, embora à margem das lutas dos movimentos sociais, elas deram sua contribuição ao afirmarem a possibilidade de uma existência fora dos padrões heteronormativos, abrindo caminhos para as novas gerações e confirmando a máxima de que “o pessoal é político”.

Palavras-chave: lésbicas; gerações; movimentos sociais; militância LGBTQIAPN+.

ABSTRACT

In this article, we depart from the experiences of twenty-one lesbians who lived their youth between the 1970s and 1990s in Belo Horizonte (Capital of Minas Gerais), in order to reflect on their possible contributions to the advancement of LGBTQIAPN+ rights, through the lens of post- structuralist feminist theory. We opted for a qualitative methodological approach, using the in-depth interview technique to trace these women´s life stories, seeking to identify their different forms of resistance when creating their own spaces of sociability, albeit segregated, in search of friendship, love, romance and sex. We conclude that, although on the sidelines of the struggles of social movements, they made their contribution by affirming the possibility of an existence outside heteronormative standards, opening paths for new generations and confirming the maxim that “the personal is political”.

Keywords: lesbians; generations; social movements; LGBTQIAPN+ activism.

RESUMEN

En este artículo partimos de los relatos de veintiuna lesbianas que vivieron su juventud entre los años 1970 y 1990 en Belo Horizonte, con el fin de reflexionar sobre sus posibles contribuciones al avance de los derechos LGBTQIAPN+, desde la lente de la teoría feminista postestructuralista. Optamos por un enfoque metodológico cualitativo, utilizando la técnica de entrevistas en profundidad para trazar las historias de vida de estas mujeres, buscando identificar sus diferentes formas de resistencia al crear sus propios espacios de sociabilidad, aunque segregados, en busca de amistad, amor, romance y sexo. Concluimos que, aunque al margen de las luchas de los movimientos sociales, han aportado su contribución afirmando la posibilidad de una existencia fuera de las normas heteronormativas, abriendo caminos a las nuevas generaciones y confirmando la máxima de que “lo personal es político”.

Palabras clave: lesbianas; generaciones; movimientos sociales; activismo LGBTQIAPN+.
PENGARUH PENDEKATAN VALUE CLARIFICATION TECHNIQUE TERHADAP HASIL BELAJAR MATA PELAJARAN AKIDAH AKHLAK
Authors: Lestari Fina Aulika , Syaifurrahman Amir , Sagala Hairun Hasanah
Published: August 2023

AbstractThis article aims to analyze the appropriate learning methods to be applied in delivering moral creed subject matter. In the moral creed lesson, the material is easy to convey, but the challenge is that students are required to be able to practice the values contained in the lesson in everyday life. This is very important related to the current phenomenon, namely the lack of morals and the many deviations that are mostly carried out by teenagers. In addition, the lack of understanding of students in the meaning of the values contained in the material of learning moral creeds causes low final grades of students. From the results of the analysis in his article, one of the methods stated is appropriate with the above problems is the Value Clarification Technique (VCT) which provides an understanding of values. Because, based on the results of the hypothesis test with the T test with the Paired Sample T Test, a sig. 2-tailed 0.00 < 0.05 then Ho was rejected and Ha was accepted, namely there is an influence of Value Clarification Technique (VCT) on the learning outcomes of moral creeds. This research is a Quasi-Experimental study, with samples used 2 classes of experiments and controls. The sampling technique used is purposive sampling. Data collection with questionnaires and documentation.  AbstrakArtikel ini bertujuan untuk menganalisis metode pembelajaran yang tepat untuk diterapkan dalam menyampaikan materi pelajaran akidah akhlak. Dalam pelajaran akidah akhlak materinya mudah disampaikan namun tantangannya peserta didik dituntut bisa mengamalkan nilai-nilai yang terkandung di dalam pelajaran tersebut dalam kehidupan sehari-hari. Hal ini yang sangat penting terkait dengan fenomena saat ini, yaitu minimnya moral dan banyaknya penyimpangan yang kebanyakan dilakukan oleh para remaja. Selain itu, kurangnya pemahaman peserta didik dalam pemaknaan nilai-nilai yang terkandung dalam materi pelajran akidah akhlak menyebabkan rendahnya nilai akhir peserta didik. Dari hasil analisis dalam artikelnya, metode yang dinyatakan tepat dengan permasalahan di atas salah satunya adalah Value Clarification Technique (VCT) yang memberikan pemahaman terhadap nilai-nilai. Sebab, berdasarkan hasil uji hipotesis dengan uji T dengan Paired Sample T Test didapatkan sig. 2-tailed 0,00 < 0,05 maka Ho ditolak dan Ha diterima yaitu terdapat pengaruh Value Clarification Technique (VCT) terhadap hasil belajar akidah akhlak. Penelitian ini merupakan penlitian Quasi Eksperimen, dengan sampel yang digunakan 2 kelas eskperimen dan kontrol. Adapun teknik sampling yang digunakan adalah purposive sampling. Pengumpulan data dengan angket dan dokumentasi.
Matematik Kimliği Ölçeği Geçerlik ve Güvenirlik Çalışması
Authors: SATMAZ İsmail , KINCAL Remzi Y.
Published: August 2023

Öğrencilerin kendilerine güvenme, yeteneklerine inanma, duygularını, düşüncelerini, anlama becerisi ile güçlü ve zayıf yönlerini bilmeleri için öncelikle kendilerini tanımaları gerekmektedir. Bu yetkinliklerin kazanılması, öğrencilerin matematik kimliklerine ilişkin tanımlamaların önemini göstermektedir. Bu çalışmanın amacı öğrencilerin matematik kimliklerinde bulunan karakteristik yapıları belirlemede kullanılabilecek nitelikte geçerli ve güvenilir bir ölçme aracı geliştirmektir. Araştırmanın evrenini 2021-2022 eğitim öğretim yılında Türkiye’nin kuzey batısında Marmara bölgesinde yer alan bir ilin Merkez ilçesinde bulunan ortaokullarda öğrenim gören 1553 beşinci sınıf öğrencisi oluşmaktadır. Örneklemi ise 1362 beşinci sınıf öğrencilerini kapsamaktadır. Matematik kimliğini belirlemeye yönelik geliştirilen ölçeğin geçerlik ve güvenirlik çalışmalarında 454 beşinci sınıf öğrencisine ölçeğin açımlayıcı faktör analizi (AFA) yapılmıştır. Ölçekte yer alan maddelerin faktör yükleri .433 ile .739 arasında değişmektedir. AFA’dan elde edilen veriler ile ölçeğin üç faktörlü yapıda olduğunu ve bu üç faktörün toplam varyansın %57,57’sini açıkladığı görülmektedir. Ölçeğin bütünü için hesaplanan Cronbach Alpha güvenirlik katsayısı ise .863 olarak bulunmuştur. Ölçeğin doğrulayıcı faktör analizi (DFA) analizleri beşinci sınıfta öğrenim gören 908 kişiden oluşan farklı bir örneklem grubu ile yapılmıştır. Yapılan DFA sonucunda ki-kare uyum indeksi değerinin serbestlik derecesine oranının (X2/sd=2,76) olduğu görülmektedir. Geliştirilen matematik kimliği ölçeğinin matematiğe karşı ilgi boyutunda 7 madde, tanınırlık boyutunda 6 madde ve performans boyutunda ise 3 madde bulunmaktadır. Araştırma sonuçları, matematik kimlik ölçeğinin 5’li Likert olarak derecelendirilmiş 16 maddeden oluşan öğrencilerin matematik kimlik yapılarının belirlenmesinde kullanılabilecek geçerli ve güvenilir bir ölçme aracı olduğunu göstermektedir.