bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship Between Personal Hygiene Behavior With The Incidence Of Scabies In Pondok Pesantren Modern Darul Hikmah Kota Medan
Authors: Damanik Muhammad Farid Zulkhair , Hemma Yulfi
Published: December 2021

Introduction. Scabies is often found in Indonesia, which is due to its tropical climate. Data showed that the prevalence of scabies Indonesia in 2013 was 6%. Poor personal hygiene, low socioeconomic status, and non-supporting health behavior are also some of the risk factors. Objectives. To identify the relationship between personal hygiene behavior with scabies in Pondok Pesantren Modern Darul Hikmah Kota Medan. Methods. This is an analytical study using cross sectional design. The sample was all the students from grade 7-12. The data was taken cardinal signs of scabies and microscopic examination towards the scrapped skin. The risk factors on personal behavior was taken thru questionnaire and direct observation on the research site. Results. The incidence of scabies in Pondok Pesantren Modern Darul Hikmah Kota Medan is 81 out of 220 respondent (36,8%). There is a strong correlation between personal hygiene behavior with incidence of scabies in Pondok Pesantren Modern Darul Hikmah Kota Medan (p=0,001). The environmental sanitation is categorized poor according to 3 aspects including clean water availability, occupant density, and personal storage availability. Conclusion. There is a strong correlation between personal hygiene behavior with the incidence of scabies in Pondok Pesantren Modern Darul Hikmah Kota Medan.
Proposta de utilização do marketing digital para captação de clientes no ascendimento da e-commerce no ramo erótico em 2021: estudo de caso na Hot Secrets
Authors: Feitoza Tharcya Lima , Fernandes Andressa Karoline , Didier Gustavo Santos , Almeida Victor da Silva , Santos Júnior Aldemir Pereira dos , Roberto José Carlos Alves
Published: December 2021

A ascensão das tecnologias tem proporcionado para as empresas diversas ferramentas para manter o relacionamento direto com seus clientes, criando assim, vínculos de fidelidade com seus consumidores, através da utilização de estratégias adequadas de marketing digital. As redes sociais proporcionaram para as empresas uma nova forma de divulgar suas marcas e serviços prestados, de forma rápida e precisa, se tornando um meio de comunicação. Tendo em vista este cenário, o presente artigo, tem como questão norteadora: Como o marketing digital e de conteúdo podem ser importantes no aumento de clientes e lucratividade de uma e-commerce em ascensão? Diante dessa realidade, o presente artigo teve como objetivo determinar as estratégias de marketing mais viáveis o aumento do consumo de produtos eróticos nas plataformas digitais na empresa pesquisada, selecionando as melhores estratégias, expandindo o engajamento, a busca de produtos eróticos e a lucratividade de e-commerce eróticos. Para entender como o marketing digital e interativo estão influenciando, realizou-se uma explanação acerca do assunto proposto, e, posteriormente, foi utilizado para coleta de dados, as bibliografias, aplicando um estudo de caso e modelos de pensamento para obtenção de informações sobre o assunto proposto. Por fim, conclui-se que as estratégias de marketing digital, se aplicadas e associadas a ações de melhoria de conteúdo e uso de marketplaces, favorece não somente as e-commerces do ramo eróticos, mas também às novas em ascensão na captação e fidelização de novos clientes, tornando esse nicho de mercado mais atrativo.
Proposta de implementação do método 8S no setor de recursos humanos: estudo de caso na Imperlave Comércio e Serviços de Móveis
Authors: Macedo Luciane Duarte , Rocha Bruna de Menezes , Avinte Maria Daniele da Silva , Almeida Victor da Silva , Santos Júnior Aldemir Pereira dos , Roberto José Carlos Alves
Published: December 2021

O referido artigo propõe um estudo de caso centrado na empresa Imperlave Comércio e Serviços de Móveis – EIRELLI, sendo esta de pequeno porte, operando neste segmento de atuação, com ênfase na prestação de serviços. Por intermédio do Diagnóstico Organizacional, destaca-se que a área de Recursos Humanos da instituição encontra-se com mais baixa classificação e envolta em demasiadas falhas. Neste contexto, o presente artigo, tem como questão norteadora: como a implementação do programa 8S na empresa Imperlave pode contribuir com as melhorias contínuas na área de recursos humanos? Para possibilitar a resolução deste questionamento, apresenta-se o objetivo geral, que é delinear a efetivação do método 8S na gestão de Recursos Humanos da empresa Imperlave. Quanto à metodologia, este trabalho possui abordagem qualitativa, bem como natureza exploratória e bibliográfica. Visa-se a utilização da ferramenta 5W2H como instrumento para introdução das ações propostas, proporcionando maior assertividade e segurança na condução dos trabalhos. Os Recursos Humanos (RH) buscam, desde seu desenvolvimento em meados dos anos 70 e 80, a fiel coordenação de toda a capacidade colaborativa, visando-se que estes envolvidos mantenham-se capacitados e motivados. Deste modo, introduz-se as ações propostas por meio dos censos colaborativos na Imperlave, pois a ferramenta apontou para uma melhor evolução em todos os envolvidos com o desenvolvimento da corporação.
Proposta de implementação do modelo de produção enxuta no gerenciamento de setores produtivos: estudo de caso empresa Real Bebidas
Authors: Oliveira André Lima de , Pontes Keilly Gabriele Cunha de , Souza Gabriel Vieira de , Almeida Victor da Silva , Santos Júnior Aldemir Pereira dos , Roberto José Carlos Alves
Published: December 2021

O presente artigo expõe sobre o estudo de caso realizado na Empresa Real Bebidas da Amazônia Ltda., evidenciando sua atuação no segmento de bebidas e refrigerantes, sendo classificada como de grande porte. O artigo verificou os problemas apontados no diagnóstico aplicado na organização, o qual identificou o setor de produção e operações como o setor com maiores deficiências. Deste modo, a pesquisa se baseou na seguinte questão norteadora: Como a inserção das ferramentas de gestão unidas a conceitos de produção enxuta podem otimizar os resultados nos setores produtivos? Espera-se que os setores produtivos desenvolvam maior qualidade, que os sensos tornem as atividades efetuadas pelos colaboradores de mais fácil manejo e ocorra melhoria contínua. Estipula-se como objetivo geral, idealizar a inserção do conceito de produção enxuta na produção e operações da empresa. A metodologia utilizada neste artigo estrutura-se como qualitativa exploratória e bibliográfica. Para as práticas das ações interventivas produzidas, se beneficiou da ferramenta interventiva 5W2H, para propor ações de melhorias internas e, por intermédio deste, implantar a padronização dos setores com conceitos de 8 sensos, introduzir Kaizen como programa em toda a organização, reduzir desperdícios, reestruturar o estoque e consolidar permanentemente todas as ações que demonstram sucesso interno. Almeja-se, com essas ações, um espaço dinâmico, colaborativo, que aumente a produtividade e desenvolva maior satisfação dos consumidores. Concebe-se que a meta da ação interventiva inserida no artigo em questão alcançou seus objetivos em desenvolver várias ações interventivas que direcionaram a instituição a resolver os problemas apontados neste diagnóstico.
A contabilidade como ferramenta de apoio a gestão nas empresas de e-commerce
Authors: Menezes Vinícius dos Santos Gonzaga , Monteiro Harrison Lucas , Roberto José Carlos Alves , Serra Meg Rocha da Cunha , Lopes Nelânia Ferreira
Published: December 2021

A contabilidade é essencial para o sistema de gestão das empresas, pois ela emite informações detalhadas sobre o patrimônio de uma sociedade empresarial. Com base no contexto das inovações tecnológicas, percebeu-se que os dispositivos sofisticados gerados pelos avanços, modificaram os mecanismos das empresas de forma externa e interna, e isso implicou na necessidade de atualização contínua pelo contador na sua maneira de operar, contribuindo com a emissão de relatórios financeiros e contábeis aprimorados, ocasionando uma gestão preparada com o amparo da contabilidade gerencial para tomada de decisões sábias, seja em situações pacíficas e até mesmo em casos extremos. Para auxiliar a investigação do tema foi abordado o seguinte problema: de que forma a contabilidade como ferramenta auxilia um negócio digital com um grande volume de informações e a mensuração de resultados? A presente pesquisa tem o objetivo de apresentar a importância do auxílio do instrumento contábil para empresas de e-commerce, demonstrando a natureza societária de uma empresa, o sistema de tributação e todas as etapas que compõem o processo de criação, legalidade e sustentabilidade das empresas, objetivando guiar o público para uma gestão qualificada. A pesquisa teve como embasamento pesquisas bibliográficas em livros, artigos, revistas de caráter científico, a partir da natureza básica. Apresenta-se neste artigo uma fundamentação que contribui com informações geradas pelos relatórios financeiros e contábeis, e sobre o papel que a contabilidade pode agregar de maneira geral, pois ela canaliza dados instaurados pelas transações e atividades das empresas, demonstrando que uma entidade que não possui um controle contábil, fica vulnerável às transformações do mercado. Conclui-se que a contabilidade como ferramenta de gestão para empresas físicas e virtuais é essencial devido a sua capacidade analítica e da sua coleta de dados que expressam toda situação patrimonial das empresas durante um espaço de tempo, e isso pode ser acompanhado pelo contador, pois ele é o profissional qualificado para compreender e realizar funções que ajudam uma entidade em vários sentidos, direcionando a empresa para o melhor caminho a ser tomado.
Orientação da formação de preços de vendas as microempresas de varejo alimentício
Authors: Valério Felipe dos Reis , Almeida Ezequiel Santos de , Roberto José Carlos Alves , Serra Meg Rocha da Cunha , Lopes Nelânia Ferreira
Published: December 2021

A presente pesquisa discorre sobre métodos de precificação à microempresas de varejo alimentício, envolvendo a gestão de preços e análise dos gastos relacionados aos produtos. Em detrimento da má gestão do estado econômico e financeiro de uma empresa, a falta do controle dos gastos, torna o ambiente mais propício ao prejuízo. Neste contexto, o presente artigo visa abordar a seguinte questão norteadora: Como esses microempreendedores formam o preço de venda dos seus produtos de modo a trazer retorno financeiro para o negócio? As respostas do questionamento da pesquisa estão pontuadas no decorrer da fundamentação teórica. Assim, o objetivo geral do estudo é mostrar a forma mais adequada de formação de preços para as microempresas de varejo alimentício. A metodologia se baseia em uma pesquisa básica e descritiva, realizada por meio de levantamentos bibliográficos. Logo, como resultado, o estudo apresenta uma compreensão sobre a precificação de um determinado produto, mostrando, a partir do estudo bibliográfico, as formas mais adequadas de formação de preços para as microempresas de varejo alimentício, além dos seus objetivos.
Primjena SfM metode u predmjeru zemljanih radova
Authors: Jurković Damjan , Marović Ivan , Galić Gorana , Imširević Emina , Grgurić Iva , Galović Andrej
Published: December 2021

Razvojem digitalnih tehnologija pojavila se mogućnost njihova korištenja u tradicionalnim granama kao što je građevinarstvo. Pritom, tradicionalne, geodetske metode koje koristimo pri predmjeru zemljanih radova mogu se osnažiti novim digitalnim metodama kao što je SfM („Structure from Motion“). Svrha korištenja navedenih digitalnih tehnologija je u dobivanju bržih i preciznijih rezultata. Predstavljena je procedura izmjere volumena SfM metodom iz 3D modela terena, koja je primijenjena na gradilištu u širem području grada Rijeke. Izrađeni su modeli stvarnog iskopa softverima Meshroom, Autodesk Recap, Meshlab i Blender. Cilj rada je usporedba točnosti rezultata proizašlih iz SfM metode s tradicionalnim, geodetskim, metodama izmjere. Dobiveni rezultat uspoređen je s planiranim volumenom iskopa i stvarnim količinama iz geodetskih snimki iskazanih u građevinskoj knjizi. Također, analizirani su problemi koji su se pojavili tijekom prikupljanja podataka i njihova modeliranja te je dana ocjena primjenjivosti ovih metoda u svakodnevnoj praksi.
THE EFFECT OF CONVERSION OF CONVENTIONAL BANKS TO ISLAMIC BANKS: EVIDENCE FROM GCC COUNTRIES
Authors: Al-Harbi Ahmad
Published: December 2021

The conversion from conventional to Islamic banking is one of the important topics in the Islamic finance industry due to non-existence of comprehensive framework for the conversion process contributing to several problems for the converted banks. Thus, the main purpose of this paper is to investigate the effect of conversion from conventional to Islamic banking on the converted banks’ operations. In addition, this paper will shed some light on the motivation behind the conversion and the process of conversion as well as providing answers to some of the problems that could hinder the conversion process. The analytical method used is ratio analysis (t-test) on the data extracted from BankScope database of five banks operating in the Gulf Cooperation Council (GCC) countries. The findings show that conversion helped to improve the performance and financial position of the converted banks, leading to sharp increases in assets, deposits, equity, and net income. Despite these benefits, however, the converted banks' profitability, efficiency, asset quality, liquidity, and risk indicators do not improve. This dichotomy may be due in part to the management’s inability to utilize the banks’ funds more efficiently to bring performance in line with increases in assets, deposits, equity, and net income. The findings indicate that the conversion methods play an important role in the conversion process because choosing the wrong method could slow or rescind the conversion. Thus, this study suggests that the conversion method and banks' management competencies must be taken into account prior to conversion.
TAHAP PRESTASI DAN FAKTOR MEMPENGARUHI PERNIAGAAN USAHAWAN ASNAF DALAM PROGRAM BANTUAN JAYADIRI: SATU ANALISIS DESKRIPTIF LEVEL OF PERFORMANCE AND FACTORS THAT AFFECT THE BUSINESS OF ASNAF ENTREPRENEURS IN THE JAYADIRI AID PROGRAMME: A DESCRIPTIVE ANALYSI
Authors: Hashim Norashidah , Othman Azizah , Mohamad Armanurah , Md. Hussin Muhammad Nasri
Published: December 2021

Kajian ini meninjau kehidupan usahawan asnaf di negeri Kedah yang menerima bantuan zakat dalam program Bantuan Jayadiri. Kertas ini membincangkan secara deskriptif tentang latar belakang peribadi, latar belakang perniagaan dan juga tahap prestasi perniagaan, bantuan zakat, simpanan, motivasi, jaringan dan latihan usahawan asnaf. Data dikumpul melalui soal selidik dan temu bual ke atas 49 orang usahawan asnaf menggunakan persampalen bertujuan di negeri Kedah. Kebanyakan mereka adalah wanita berbangsa Melayu, berkahwin dan berpendidikan di peringkat sekolah menengah, terlibat dalam perniagaan berasaskan makanan yang sedang berkembang. Dengan menggunakan analisis deskriptif, kajian ini mendapati prestasi perniagaan, bantuan zakat, motivasi, jaringan berada pada tahap min yang tinggi. Manakala simpanan dan latihan di tahap min sederhana. Dapatan ini menunjukkan usahawan asnaf memerlukan lagi bantuan zakat dan program latihan bagi membantu mereka untuk meningkatkan prestasi perniagaan dan simpanan kewangan seterusnya keluar dari kemelut kemiskinan serta menjadi pembayar zakat pada masa akan datang.
RELIGION AND MONEY: PREDICTORS OF EMPLOYEE COMMITMENT WITHIN THE HEALTH SECTOR
Authors: Afzal Seema , Azmi Ilhaamie Abdul Ghani
Published: December 2021

Employee workplace commitment is one of an imperative topic nowadays in the organizational studies. Religion and money are among the several antecedents of employee commitment in organizations. Employees’ religion and organizational monetary reward practices are of eagerly importance in an employee career. Organizations have been facing lack of commitment in their workforce because of less consideration on the monetary as well as spiritual aspects. A comparative analysis between these two antecedents will be helpful to find out the true aspect behind this shortfall in the health sector. This study aims to investigate the relationship between monetary reward practices and religious affiliation with employee commitment. Data was collected from 233 Muslim employees of the health sector of Pakistan and the correlation and regression analysis were done by SPSS. The findings interpret that monetary reward practices were found to be highly related to employee commitment and having more effective influence as compared to employee’s religious affiliation. The current study suggests the health sector of Pakistan to take an account in providing monetary benefits to the employees to strengthen their workplace commitment.
MODEL DANA TAMBAHAN BAGI PENAWARAN TAKAFUL MIKRO KEPADA WARGA EMAS
Authors: Kamal Asiah , Sulaiman@Mohamad Ahmad Azam , Mohamad Mohammad Taqiuddin
Published: December 2021

Pada tahun 2030, Malaysia di jangka mencapai status negara tua apabila penduduk yang berumur 60 tahun dan ke atas meningkat seramai 5.6 juta orang iaitu 15% daripada jumlah keseluruhan penduduk. Berdasarkan statistik ini, kajian dijalankan untuk mengkaji penawaran takaful mikro kepada warga emas yang perlu ditawarkan menggunakan dana tambahan. Oleh itu, artikel ini merangka model-model dana tambahan bagi penawaran takaful mikro kepada warga emas. Metodologi kajian secara kualitatif digunakan untuk mencapai tujuan kajian yang melibatkan temu bual dengan pengawal selia syarikat takaful, tiga syarikat takaful yang menawarkan produk takaful mikro di bawah inisiatif “Perlindungan Tenang” dan penilai model yang melibatkan wakil industri serta dua orang ahli akademik yang terlibat sebagai penasihat syariah bagi menilai model penggunaan dana yang digunakan. Hasil dapatan kajian telah membentuk model penawaran takaful mikro menggunakan model wakaf dan endowmen, model CSR wakaf, model zakat dan kombinasi dana daripada pelbagai sumber sebagai dana tambahan dalam penawaran takaful mikro kepada warga emas.
STRENGTHENING HALAL TOURISM DEVELOPMENT IN RIAU PROVINCE IN INDONESIA
Authors: Ishak Khodijah , Mahfudz Akhmad Afandi , Basri Yuswar Zainul , Mariyanti Tatik , Zulhelmy Zulhelmy
Published: December 2021

This study explore and analyze the problems of halal tourism’s development in Riau Province with an Analytic Network Process (ANP) approach. The method used is the Analytic Network Process (ANP) which is a qualitative and quantitative method approach. The type of data that will be used in this research is the primary data and the form of the subject (self-report data). The samples used as respondents in this study were those who were considered experts in the field of halal tourism, namely the government in this case the ministry of tourism, tourism practitioners, regulators or perpetrators industrial activist in the field of tourism, Halal Product Guarantee Agency business and academics took by purposive sampling. The variables of this research are regulation, literacy, human resources, infrastructure, government policies, certification, government commitment, and socio-culture. The findings shows that the internal problems faced in the development of Halal tourism in Riau province based on the order of priority were infrastructure problems, regulatory issues, human resource problems, and literacy problems. Other findings indicate that the external problems faced are based on priority order, including government commitment issues, government policy issues, certification issues, and socio-cultural problems. The Managerial implications for halal tourism stakeholders in Riau province, especially the local government to pay attention to issues of infrastructure development, particularly access to places of halal tourism and have a strong commitment in developing halal tourism in the province.
Poverty in American Higher Education
Authors: Broton Katharine
Published: December 2021

A substantial share of college students experience housing insecurity and too many students leave higher education before earning a credential. Both of these experiences are more common among students from low-income families who often lack adequate resources. While prior conceptual and qualitative investigations suggest that housing insecurity is associated with poorer student outcomes, this relationship has not been tested due to quantitative data limitations. In this paper, I use data from a state-wide longitudinal study of students from low-income families to conduct the first empirical test of the relationship between housing insecurity early in college and later college achievement and attainment. Findings show that housing insecurity is a statistically significant predictor of academic success, net of background factors. Specifically, housing insecurity is associated with an 8 to 12 percentage-point reduction in the probability of later degree attainment or enrollment. In the short-term, housing insecurity is also associated with lower mean GPA, a lower probability of obtaining at least a 2.0 GPA, and a higher probability of enrolling part-time rather than full-time, indicating that housing insecurity affects students’ college academic experiences in multiple ways. Efforts to promote college attainment should be expanded to consider students’ housing security. There are likely several points in time and multiple ways that higher education institutions, nonprofit agencies, and policymakers can intervene to promote secure housing and college success.
MINI WHEEL APPLICATION ON HOUSEHOLD SCALE AQUACULTURE OF GIANT FRESHWATER PRAWNS (Macrobranchium rosenbergii)
Authors: Kristiana Indra , Amatullah Igfirlii , Pietoyo Atiek , Prabowo DH Guntur , Sudinno Dinno
Published: December 2021

Giant freshwater prawns, one of the freshwater aquaculture commodities which has high economic value and has wide market opportunity. Dissolved oxygen on giant freshwater prawn aquaculture is the one of necessary part on a prawn weight gain. Availability of dissolved oxygen can be increased by optimalization on mini wheel and blower use. Mini Wheel is a part of aquaculture technology application, especially on household scale aquaculture of giant freshwater prawn (M. rosenbergii). This assembly used recycle material which can still be used. This mini wheel was modified by 3 treatments, that A (blower without mini wheel pond treatment); B (one-propeller mini wheel pond treatment); C (two-propeller mini wheel pond treatment). This research used quantitative method and every treatment should has three repetitions. Aquaculture a household scale by applying mini wheel designed to find out its effect on water quality and growth of giant freshwater prawn (M. rosenbergii), with parameter ABW (Average Body Weight), ADG (Average Daily Growth), FCR (Feed Convertion Ratio) and SR (Survival Rate). This research showed that there is a significant difference between two-propeller mini wheel pond treatment, one-propeller mini wheel pond treatment and blower without mini wheel pond treatment. The optimum Dissolved Oxygen value on two-propeller mini wheel pond treatment was about 9 mg/L (morning and afternoon testing), Pond temperature on range 280C, and also pH has stability on 7. The best growth was found in two-propeller mini wheel pond treatment with Survival Rate (SR) 93%, Average Body Weight (ABW) 10 g/prawn, Average Daily Growth (ADG) 0.11 g/prawn, and Feed Convertion Ratio (FCR) 1.5.
A peculiaridade do estético e a emancipação humana: a arte em Aristóteles e Lukács
Authors: Dos Santos Rosa Daniele
Published: December 2021

Este artigo tem por objetivo investigar a especificidade da forma literária em sua relação com a possibilidade de construção de caminhos para a emancipação humana, por meio do estudo da presença, transformação e atualidade dos conceitos aristotélicos na obra lukacsiana, já que para estes dois estetas a arte se coloca como ação  humana incontornável para a sua desfetichização. Por meio de um estudo detido de algumas categorias teóricas, apreentaadas principalmente na Poética, de Aristóteles, e na Estética, de Lukács, foi possível compreender como a arte, enquanto expressão das potencialidades humanas, possibilita – além de uma compreensão mais profunda da experiência humana – a contrução de um sentido ao mundo, um sentido ontogênico, base para qualquer possibilidade de transformação.
Kasnosrednjovjekovna
plemićka kurija kraj Orahovice
Authors: Emić Marin
Published: December 2021

U radu su predstavljeni rezultati analize dijela pokretnih nalaza prikupljenih arheološkim istraživanjima kurije kraj Orahovice 2017. i 2019. godine. Također, donose se rezultati proučavanja kurije u odnosu na slične rezidencije na području srednjovjekovnoga Ugarskog Kraljevstva. Srednjovjekovna kurija kraj Orahovice nalazi se u podnožju Ružice grada, jedne od najvećih utvrda u Hrvatskoj. Orahovičkim posjedom vladali su brojni istaknuti pojedinci među kojima se ističe Nikola Iločki kao jedan od najvećih magnata kasnosrednjovjekovnoga Ugarskog Kraljevstva. Iznimno malo izvora spominje kuriju te pri tome ne donose dodatne informacije o njoj. Arheološka istraživanja započela su 2017. godine te su nastavljena 2019. i 2020. godine. Od pokretnih nalaza pronađeni su uglavnom karakteristični kasnosrednjovjekovni i ranonovovjekovni keramički nalazi. Značajan je nalaz novca Žigmunda Luksemburškog kovan između 1430. i 1437. godine. Za sada su prepoznate tri faze dogradnji zidova na glavnu troprostornu zgradu kurije. Istraživanjima 2020. godine otkrivene su strukture u blizini kurije koje ukazuju na postojanje većega kompleksa. Na području kontinentalne Hrvatske do sada nisu prepoznate i istražene slične kasnosrednjovjekovne kurije. Proučavanjem kuriji kraj Orahovice sličnih rezidencija na području kasnosrednjovjekovnoga Ugarskog Kraljevstva uočena je skupina rezidencijalno-gospodarskih kompleksa koja bi mogla igrati važnu ulogu u razumijevanju i interpretaciji rezultata daljnjih arheoloških istraživanja na ovome lokalitetu.
Novi stakleni
nalazi iz tereta broda Gagliana grossa potonuloga kod otočića Gnalića 1583.
Authors: Šelendić Ines , Radić Rossi Irena
Published: December 2021

Mletački trgovački brod natovaren raznovrsnim teretom potonuo je kod otočića Gnalića krajem listopada ili početkom studenoga 1583. Brodski se teret sastojao od sirovina, poluproizvoda i gotovih proizvoda namijenjenih carigradskome tržištu i sultanovome dvoru, što je višestruko potvrđeno arheološkim i povijesnim istraživanjima. Među gotovim proizvodima posebno se ističe velika količina staklenih predmeta podijeljenih u dvije glavne skupine: šuplje i ravno staklo. Prva skupina obuhvaća raznolike oblike stolnoga posuđa, spremnika za hranu i piće i staklenih perli, dok se u drugoj nalaze prozorska stakla i stakla za ogledala. Nakon službenoga otkrića nalazišta 1967. godine, organizirano je pet zaštitnih istraživačkih kampanja s ciljem pravovremenoga spašavanja najvrjednijih nalaza. Nakon 1973. aktivnosti zaštitne prirode kratkotrajno su obnovljene 1996., a sustavno istraživanje, primjereno značenju i stanju nalazišta, započelo je tek 2012. godine. Prve sistematizacije staklene građe izradili su Sofija Petricioli i Astone Gasparetto. U okviru međunarodnoga projekta The Heritage of the Serenissima 2004. godine Irena Lazar, Hugh Willmott i Caroline Jackson sustavno su obradili staklene nalaze. Tijekom istraživanja 2012. – 2020., usmjerenih poglavito na otkrivanje i dokumentiranje brodske konstrukcije, izvađene su tisuće ulomaka staklenih predmeta. Iako je u većini slučajeva riječ o primjercima stolnoga posuđa i ravnoga stakla, koji se u potpunosti uklapaju u do sada predloženu tipologiju staklenih nalaza iz brodskoga tereta, u nekim slučajevima primjećuju se i određene razlike. U radu su predstavljeni novi nalazi koji dopunjuju dosadašnje spoznaje ili ukazuju na mogućnost različite interpretacije ranijih nalaza.
L'informatizzazione Della Cartella Clinica
Authors: Quintaliani G. , Ricci R. , De Megni L. , Buoncristiani U.
Published: December 2021

Abstract non disponibile
O Regime Militar Brasileiro e o Autoritarismo: uma revisão sobre a institucionalização da repressão política e a “Democracia Controlada”
Authors: Inácio Tiago Viesba Pini , Silva Márcia da
Published: December 2021

O artigo analisa o Regime Militar Brasileiro (1964-1984) no que tange à institucionalização da repressão e do projeto geopolítico dos militares e à ruptura com a democracia. As Forças Armadas, orientadas pela Doutrina de Segurança Nacional, são chamadas para pensar estratégias que permitam a segurança do território nacional, de acordo com as suas premissas. Para justificarmos esta concepção geopolítica, analisamos o contexto do Golpe Militar de 1964 e a forma como a Doutrina de Segurança Nacional constatou a presença de uma ameaça interna ao Estado Brasileiro e à sociedade civil, ou seja, incentivando a constituição de um Estado ditatorial que protegesse o território nacional. A metodologia de pesquisa adotada foi uma revisão bibliográfica acompanhada da análise de documentos e dados da Comissão da Verdade. Entre os resultados obtidos, destacamos que o Golpe de 1964 e a construção do Regime Militar tem origem no discurso geopolítico dos militares brasileiros. Além do mais, para salvar a segurança nacional, justificou-se a ruptura da democracia brasileira e a tomada de ações autoritárias na busca do “inimigo interno e subversivo”.
Specific Design Solution for Covering Large Areas With Spatial Metal Truss
Authors: Marufiy A. , Rysbekova E.
Published: December 2021

. The relevance of the research results given in the article lies in the need to apply new constructive solutions for large spaces. The purpose of this work is to search for new design solutions for covering large areas with spatial metal trusses. The problems of forming a computational spatial bar finite element model of a steel spatial truss of a dome-shaped radial-ring structure were solved. The calculation of the spatial system was carried out using the finite element method of current computer programs, new constructive solutions for spatial metal trusses were adopted. The stress-strain states of the model from a given load have been determined. The calculation of the spatial system was carried out using the finite element method of current computer programs, new constructive solutions for spatial metal trusses were adopted. The research results can be used in the formation of architectural and structural solutions of a building using a new structural arrangement of the elements of a spatial truss.
Features of Digitalization in the Construction Industry as an Important Factor of Its Sustainable Development
Authors: Voskovykh K.
Published: December 2021

This article determines that in the context of global digitalization, the competitiveness and sustainable development of companies depend on the speed of mastering new technologies. Assessment of the current level of the construction industry indicates its lag behind other industries. The aim of the study is to analyze the current level of digitalization of construction companies and summarize the constraining factors. The importance of continuous digitization of production and logistics, networking of autonomous smart objects or the use of self-learning systems in order to increase flexibility and optimize processes is emphasized. The main benefit of implementing digital business models is reducing the time it takes to make decisions, implement a project, and bring products to market. The factors holding back digital processes at the construction site are highlighted: a high proportion of manual production, over-regulation, dependence on the public sector and cyclical changes, the scale of the company. New technologies resulting from the fourth industrial revolution promise more efficient processes, greater time and cost savings, greater productivity and quality. The construction industry must catch up with other industries, because it also has to face the challenges of globalization, urbanization, climate change, resource scarcity, demographic change and other events that disrupt its sustainable development. Construction Site 4.0 promises improvements, but the fourth industrial revolution on the construction site is just beginning.
A Novel Function of Mitochondrial Phosphoenolpyruvate Carboxykinase as a Regulator of Inflammatory Response in Kupffer Cells
Authors: Dong Haibo , Feng Yue , Yang Yang , Hu Yun , Jia Yimin , Yang Shu , Zhao Nannan , Zhao Ruqian
Published: December 2021

Background:There has been a recent appreciation that some metabolic enzymes can profoundly influence the nature of the immune response produced in macrophages. However, the role of mitochondrial phosphoenolpyruvate carboxykinase (PCK2) in immune response remains unknown. This study aims to investigate the role of PCK2 in lipopolysaccharides (LPS)-induced activation in Kupffer cells.

Methods:Inflammatory cytokines were determined by real-time quantitative reverse transcription-polymerase chain action (qRT-PCR) and flow cytometric analysis using a cytometric bead array. Western blotting and immunofluorescence staining were used to determine PCK2 expression and subcellular distribution under confocal laser microscopy. qRT-PCR, flow cytometry, and high-performance liquid chromatography (HPLC) were used to determine mitochondrial function. Pharmacological inhibition, knockdown, and overexpression of PCK2 were used to confirm its function. Co-immunoprecipitation (Co-IP) was performed to determine MAPK/NF-κB phosphorylation.

Results:Inflammatory response was significantly increased in LPS-treated mice and Kupffer cells. During the inflammatory process, the protein level of PCK2 was significantly upregulated in Kupffer cells. Interestingly, the localization of PCK2 was mainly in cytosol rather than mitochondria after LPS stimulation. Gain-of-function and loss-of-function analyses found that PCK2 overexpression significantly upregulated the levels of inflammation markers, whereas PCK2 knockdown or inhibition significantly mitigated LPS-induced inflammatory response in Kupffer cells. Furthermore, PCK2 promoted protein phosphorylation of NF-κB and AKT/MAPK, the major signaling pathways, controlling inflammatory cascade activation.

Conclusion:We identified a novel function of PCK2 in mediating LPS-induced inflammation and provided mechanistic insights into the regulation of inflammatory response in Kupffer cells. Therefore, PCK2 may serve as a novel therapeutic target for the regulation of Kupffer cells-mediated inflammatory responses.
Glucocorticoids Promote Extracellular Matrix Component Remodeling by Activating YAP in Human Retinal Capillary Endothelial Cells
Authors: Gu Xianliang , Ge Lingling , Ren Bangqi , Fang Yajie , Li Yijian , Wang Yi , Xu Haiwei
Published: December 2021

Remodeling of extracellular matrix (ECM) components of endothelial cells is the main cause of retinal vascular basement membrane (BM) thickening, which leads to the initiation and perpetuation of microvasculopathy of diabetic retinopathy (DR). Excessive amounts of glucocorticoids (GCs) are related to the presence and severity of DR, however transcriptional effects of GCs on the biology of human retinal capillary endothelial cells (HRCECs) and its impacts on DR are still unclear. Here, we showed that GC (hydrocortisone) treatment induced ECM component [fibronectin (FN) and type IV collagen (Col IV)] expression and morphological changes in HRCECs via the glucocorticoid receptor (GR), which depended on the nuclear translocation of YAP coactivator. Mechanistically, GCs induced stress fiber formation in HRCECs, while blocking stress fiber formation inhibited GC-induced YAP nuclear translocation. Overexpression of FN, but not Col IV, activated YAP through the promotion of stress fiber formation via ECM-integrin signaling. Thus, a feedforward loop is established to sustain YAP activity. Using mRNA sequencing of HRCECs with overexpressed YAP or GC treatment, we found a similarity in Gene Ontology (GO) terms, differentially expressed genes (DEGs) and transcription factors (TFs) between the two RNA-seq datasets. In vivo, YAP was activated in retina vascular ECs of STZ-induced diabetic mice, and TF prediction analysis of published RNA-seq data of dermal vascular ECs from T2DM patients showed that GR and TEAD (the main transcription factor for YAP) were enriched. Together, GCs activate YAP and promote ECM component (FN and Col IV) remodeling in retinal capillary endothelial cells, and the underlying regulatory mechanism may provide new insights into the vascular BM thickening of the retina in the early pathogenesis of DR.
A Diagnostic Nomogram Based on 18F-FDG PET/CT for Bone Metastasis of Gastric Cancer
Authors: Wu Chunhui , Lin Xiaoping , Li Zhoulei , Chen Zhifeng , Xie Wenhui , Zhang Xiangsong , Wang Xiaoyan
Published: December 2021

Purpose: To develop an effective diagnostic model for bone metastasis of gastric cancer by combining 18F-FDG PET/CT and clinical data.

Materials and Methods: A total of 212 gastric cancer patients with abnormal bone imaging scans based on 18F-FDG PET/CT were retrospectively enrolled between September 2009 and March 2020. Risk factors for bone metastasis of gastric cancer were identified by multivariate logistic regression analysis and used to create a nomogram. The performance of the nomogram was evaluated by using receiver operating characteristic curves and calibration plots.

Results: The diagnostic power of the binary logistic regression model incorporating skeleton-related symptoms, anemia, the SUVmax of bone lesions, bone changes, the location of bone lesions, ALP, LDH, CEA, and CA19-9 was significantly higher than that of the model using only clinical factors (p = 0.008). The diagnostic model for bone metastasis of gastric cancer using a combination of clinical and imaging data showed an appropriate goodness of fit according to a calibration test (p = 0.294) and good discriminating ability (AUC = 0.925).

Conclusions: The diagnostic model combined with the 18F-FDG PET/CT findings and clinical data showed a better diagnosis performance for bone metastasis of gastric cancer than the other studied models. Compared with the model using clinical factors alone, the additional 18F-FDG PET/CT findings could improve the diagnostic efficacy of identifying bone metastases in gastric cancer.
The Appropriateness Criteria of Abdominal Fat Measurement at the Level of the L1-L2 Intervertebral Disc in Patients With Obesity
Authors: Sun Jing , Lv Han , Zhang Meng , Li Mengyi , Zhao Lei , Zeng Na , Liu Yawen , Wei Xuan , Chen Qian , Ren Pengling , Liu Yang , Zhang Peng , Yang Zhenghan , Zhang Zhongtao , Wang Zhenchang
Published: December 2021

Background

In this study, we proposed to use MR images at L1-L2 (lumbar) intervertebral disc level to measure abdominal fat area in patients with obesity. The quantitative results would provide evidence for the individualized assessment of the severity of obesity.

Methods

All patients in the IRB-approved database of Beijing Friendship Hospital who underwent bariatric surgery between November 2017 and November 2019 were recruited. We retrospectively reviewed upper abdominal magnetic resonance (MR) data before surgery. We analyzed the correlation and consistency of the area of abdominal subcutaneous adipose tissue (ASAT) and visceral adipose tissue (VAT) measured at the L1-L2 and L2-L3 levels on MR images. We randomly distributed the cases into prediction model training data and testing data at a ratio of 7:3.

Results

Two hundred and forty-five subjects were included. The ASAT and VAT results within the L1-L2 and L2-L3 levels were very similar and highly correlated (maleASAT: r=0.98, femaleASAT: r=0.93; maleVAT: r=0.91, femaleVAT: r=0.88). There was no substantial systematic deviation among the results at the two levels, except for the ASAT results in males. The intraclass correlation coefficients (ICCs) were 0.91 and 0.93 for maleASAT and femaleASAT, and 0.88 and 0.87 for maleVAT and femaleVAT, respectively. The ASAT/VAT area at the L2-L3 level was well predicted. The coefficient β of linear regression that predicted L2-L3 ASAT from L1-L2 ASAT was 1.11 for males and 0.99 for females. The R-squares were 0.97 and 0.91, respectively. For VAT prediction, the coefficient β was 1.02 for males and 0.96 for females. The R-squares were 0.82 and 0.77, respectively.

Conclusion

For patients with obesity, the L1-L2 intervertebral disc level can be used as the substitution of L2-L3 level in abdominal fat measurement.
Galactose-Binding C-Type Lectin Promotes Cellular Aggregation of Coelomocytes in Sea Cucumber
Authors: Taguchi Mizuki , Tanaka Chikaya , Tsutsui Shigeyuki , Nakamura Osamu
Published: December 2021

Echinoderms have a large coelomic cavity containing coelomocytes. When the coelomic fluid is removed from the cavity, the cells aggregate immediately. We found that a fraction or an extract of the intestine of the sea cucumber, Apostichopus japonicus, markedly accelerated cellular movement and aggregation on a glass slide, and this effect was clearly inhibited by galactose. We successfully purified the aggregation-promoting factor, a 16 kDa protein, from the intestine. TOF-MS analysis followed by de novo sequencing revealed that the protein is a C-type lectin. RNA-seq data and cDNA cloning demonstrated the factor to be a novel lectin, named AjGBCL, consisting of 158 aa residues in the mature form. Microscopic observation revealed that most of the aggregating cells moved toward aggregates and not to an intestinal fragment, suggesting that AjGBCL is not a chemoattractant but a cellular aggregation-inducing factor that may induce aggregates to release chemoattractant. We report, for the first time, an endogenous molecule that promotes coelomocyte aggregation in echinoderms.
Baseline Characteristics of Mitochondrial DNA and Mutations Associated With Short-Term Posttreatment CD4+T-Cell Recovery in Chinese People With HIV
Authors: Liu Anni , Wei Qian , Lin Haijiang , Ding Yingying , Sun Yan V. , Zhao Dan , He Jiayu , Ma Zhonghui , Li Feihu , Zhou Sujuan , Chen Xiaoxiao , Shen Weiwei , Gao Meiyang , He Na
Published: December 2021

Background

Mitochondrial DNA (mtDNA) profiles and contributions of mtDNA variants to CD4+T-cell recovery in Euramerican people living with HIV (PLWH) may not be transferred to East-Asian PLWH, highlighting the need to consider more regional studies. We aimed to identify mtDNA characteristics and mutations that explain the variability of short-term CD4+T-cell recovery in East-Asian PLWH.

Method

Eight hundred fifty-six newly reported antiretroviral therapy (ART)-naïve Chinese PLWH from the Comparative HIV and Aging Research in Taizhou (CHART) cohort (Zhejiang Province, Eastern China) were enrolled. MtDNA was extracted from peripheral whole blood of those PLWH at HIV diagnosis, amplified, and sequenced using polymerase chain reaction and gene array. Characterization metrics such as mutational diversity and momentum were developed to delineate baseline mtDNA mutational patterns in ART-naïve PLWH. The associations between mtDNA genome-wide single nucleotide variants and CD4+T-cell recovery after short-term (within ~48 weeks) ART in 724 PLWH were examined using bootstrapping median regressions.

Results

Of 856 participants, 74.18% and 25.82% were male and female, respectively. The median age was 37 years; 94.51% were of the major Han ethnicity, and 69.04% and 28.62% were of the heterosexual and homosexual transmission, respectively. We identified 2,352 types of mtDNA mutations and mtDNA regions D-loop, ND5, CYB, or RNR1 with highest mutational diversity or volume. Female PLWH rather than male PLWH at the baseline showed remarkable age-related uptrends of momentum and mutational diversity as well as correlations between CD4+T <200 (cells/μl) and age-related uptrends of mutational diversity in many mtDNA regions. After adjustments of important sociodemographic and clinical variables, m.1005T>C, m.1824T>C, m.3394T>C, m.4491G>A, m.7828A>G, m.9814T>C, m.10586G>A, m.12338T>C, m.13708G>A, and m.14308T>C (at the Bonferroni-corrected significance) were negatively associated with short-term CD4+T-cell recovery whereas m.93A>G, m.15218A>G, and m.16399A>G were positively associated with short-term CD4+T-cell recovery.

Conclusion

Our baseline mtDNA characterization stresses the attention to East-Asian female PLWH at risk of CD4+T-cell loss-related aging and noncommunicable chronic diseases. Furthermore, mtDNA variants identified in regression analyses account for heterogeneity in short-term CD4+T-cell recovery of East-Asian PLWH. These results may help individualize the East-Asian immune recovery strategies under complicated HIV management caused by CD4+T-cell loss.
The Associations of Caesarean Delivery With Risk of Wheezing Diseases and Changes of T Cells in Children
Authors: Lin Jilei , Yuan Shuhua , Dong Bin , Zhang Jing , Zhang Lei , Wu Jinhong , Chen Jiande , Tang Mingyu , Zhang Bin , Wang Hansong , Dai Yuanyuan , Liu Shijian , Hu Yabin , Qi Xinyi , Xu Liangye , Zhao Liebin , Yin Yong
Published: December 2021

Objectives

This study aimed to assess the associations of caesarean delivery (CD) with risk of wheezing diseases and changes of immune cells in children.

Design

The cross-sectional study was conducted between May, 2020 and April, 2021.

Setting and participants

The study was conducted in Shanghai Children’s Medical Center, Shanghai, China. A total of 2079 children with a mean age of 36.97 ± 40.27 months and their guardians were included in the present study via face-to-face inquiry and physical examination by clinicians.

Methods

Logistic regression was applied to estimate odds ratio (ORs) and 95% confidence intervals (CIs) for the association between CD and first episode of wheezing (FEW) or asthma. Models were adjusted for premature or full-term delivery, exclusive breastfeeding (at least 4 months) or not.

Results

Among the 2079 children, 987 children (47.47%) were born by CD and 1092 (52.53%) by vaginal delivery (VD). Children delivered by caesarean had significantly lower gestational age (P<0.01) compared with those who delivered vaginally. Our results also showed that CD was related to increased risk of FEW by the age of 3(adjusted OR 1.50, 95%CI 1.06, 2.12) and increased tendency to develop asthma by the age of 4 (adjusted OR 3.16, 95%CI 1.25, 9.01). The subgroup analysis revealed that the negative effects of CD on asthma were more obvious in children without exclusive breastfeeding (adjusted OR 4.93, 95%CI 1.53, 21.96) or without postnatal smoking exposure (adjusted OR 3.58, 95%CI 1.20, 13.13). Furthermore, compared with children born through VD, a significant change of the T cells (increased proportion of CD4+ T cells and decreased number and proportion of CD8+ T cells) were observed before the age of one in the CD group. However, the changes were insignificant in children over 1 year old.

Conclusions

This study showed age-dependent associations of CD with asthma and FEW in offspring. Moreover, CD appeared to have an effect on the cellular immunity in infants, the disorder of which may contribute to the development of asthma in children.