bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S2 from Interleukin-5 Facilitates Lung Metastasis by Modulating the Immune Microenvironment
Authors: Zaynagetdinov Rinat , Sherrill Taylor P. , Gleaves Linda A. , McLoed Allyson G. , Saxon Jamie A. , Habermann Arun C. , Connelly Linda , Dulek Daniel , Peebles R. Stokes , Fingleton Barbara , Yull Fiona E. , Stathopoulos Georgios T. , Blackwell Timothy S.
Published: April 2023

Figure S2. Deficiency in IL-5 does not affect infiltration of lungs with T and B lymphocytes and NK cells during initial stages of metastatic load of LLC cells.
Supplementary Figure S5 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: April 2023

Orthotopic lung tumorigenesis following injection of tumor derived cell lines of defined Kras or Pik3ca genotype.
Supplementary Figure S3 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: April 2023

Analysis of the consequences of the timing of KRASG12D versus PIK3CAH1047R oncoprotein expression on lung tumorigenesis.
Supplementary Figure 7 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Authors: Caetano Mauricio S. , Zhang Huiyuan , Cumpian Amber M. , Gong Lei , Unver Nese , Ostrin Edwin J. , Daliri Soudabeh , Chang Seon Hee , Ochoa Cesar E. , Hanash Samir , Behrens Carmen , Wistuba Ignacio I. , Sternberg Cinthya , Kadara Humam , Ferreira Carlos Gil , Watowich Stephanie S. , Moghaddam Seyed Javad
Published: April 2023

Supplementary Figure 7. Relative expression of Scgb1 (CCSP) mRNA in lungs of CC-LR mice.
Supplementary Figure 3 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Authors: Caetano Mauricio S. , Zhang Huiyuan , Cumpian Amber M. , Gong Lei , Unver Nese , Ostrin Edwin J. , Daliri Soudabeh , Chang Seon Hee , Ochoa Cesar E. , Hanash Samir , Behrens Carmen , Wistuba Ignacio I. , Sternberg Cinthya , Kadara Humam , Ferreira Carlos Gil , Watowich Stephanie S. , Moghaddam Seyed Javad
Published: April 2023

Supplementary Figure 3. Increased levels of IL-6 in bronchoalveolar lavage fluid (BALF) of CC-LR mice during tumor progression.
Supplementary Figure S5 from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: April 2023

LCmodel analysis between 3.9 and 0.5 ppm.
Supplementary Figure S4 from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: April 2023

Phantom experiments and density-matrix simulations of the timing of the semi-LASER sequence were performed at TE = 36 (TE1 =11 ms, TE2 = 15 ms and TE3 = 10 ms) and 110 ms (TE1 =11 ms, TE2 = 65 ms and TE3 = 34 ms).
Supplementary Figure S1 from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: April 2023

LCModel analysis.
Table S4. Key genes involved with anti-proteasomal response in L428 cells. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: April 2023

These key genes were determined by finding the common genes between the significant upstream regulators, biofunction analysis, and Gene Set Enrichment Analysis (GSEA) for GO gene sets with a FDR < 0.05 for ixazomib 25nM/24 hours vs. Control for L428 cells. The second column denotes the effects these genes have on tumor progression based on the literature. Genes with no reported effects on tumors were identified as Not Determined (ND).
Supplemental Methods, Tables 1-9, and Figures 1-9 from Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis
Authors: Zhong Rong , Bao Riyue , Faber Pieter W. , Bindokas Vytautas P. , Bechill John , Lingen Mark W. , Spiotto Michael T.
Published: April 2023

Supplemental Methods, Tables 1-9 and Figures 1-9. Supplemental Methods: Animals; Sleeping Beauty transposon mapping; Reagents and antibodies; HPV recombination, T2/Onc excision and Hras mutation specific PCRs. Supplemental Table 1: Mouse strains used in this study. Supplemental Table 2: Primers used in the generation of insertional mutagenesis libraries. Supplemental Table 3: Common insertion sites (CIS) in DMBA and 4-NQO treated HPV-positive and HPV-negative tumors. Supplemental Table 4: Characterizations of Notch1 insertions. Supplemental Table 5: Transposon orientation and frequency for candidate genes in Figure 3B. Supplemental Table 6: Differentially expressed genes in KHR compared to KHR-N-/- and KHR-N+/- tumors. Supplemental Table 7: Differentially expressed genes in KHR-N-/- compared to KHRNICD tumors. Supplemental Table 8: Comparison of pathway analysis for KHR-N+/- and KHR-N-/- tumors compared to KR-N-/- tumors. Supplemental Table 9: Summary of GSEA Hallmark gene sets significantly enriched in KHRNICD and KHR-N-/- tumors. Supplemental Figure 1. LSL-HPV recombination, T2/Onc transposition and Ha-Ras mutations in HPV-positive and HPV-negative tumors. Supplemental Figure 2. Sleeping Beauty insertional mutagenesis accelerated tumorigenesis in 4-NQO treated HPV-positive and HPV-negative mice. Supplemental Figure 3. Tumors with activating T2/Onc insertions have higher Notch1 expression compared to tumors with inactivating T2/Onc insertions. Supplemental Figure 4. Validation of NICD expression in KHRNICD oral tumors. Supplemental Figure 5. KHRNICD oral tumors had increased Hes1 and Hey1 nuclear expression. Supplemental Figure 6. KHR and KHRNICD oral tumors had similar CK14 expression. Supplemental Figure 7. KHR and KHR-Notch1+/- and KHR-Notch1-/- oral tumors had similar CK14 expression. Supplemental Figure 8. KHR, KHR-Notch+/- and KHR-Notch-/- oral tumors have invasive components. Supplemental Figure 9. NOTCH1 somatic mutations in ALTCL, CESC and HNSC patients.
Figure S2. Network representation of Gene Set Enrichment Analysis (GSEA) for Biological pathways. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: April 2023

A. Reactome, B. KEGG, C. MYC Pathways, extract from C2 gene sets for ixazomib 24 hours versus control for Jurkat, L540, and L428 cells, with L540 overlaid with either Jurkat or L428. Leading edge analysis with a FDR<0.05 determined significant gene sets enriched for each group. The size of each node reflects the amount of molecules involved for each gene set. The edge thickness (green lines for L540 and blue lines for either Jurkat or L428) represents the number of genes associated with the overlap of two gene sets (or nodes) that the edge connects. Clusters in each grouping were named according to common function. Upregulated gene sets denoted with red color and downregulated gene sets were denoted by blue color.
Figure S1. Quantitative RT-PCR validation of ixazomib genes. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: April 2023

The bar graph show results (as fold-change values) from quantitative RT-PCR validation of the following genes, MYC, lysosomal - SQSTM1/p62, proteasomal function- PSMB3, PSMB5, PSMD1, PSMD2, common overlapping gene- PSAP, with RNA isolated from control and ixazomib treated Jurkat (TCL) and L540 and L428 (HL) cells, and comparison with the results from microarray experiment. The calculated the p-values (* = p < 0.05, ** = p < 0.01, and *** p < 0.001), were determined based on the fold change values between control and ixazomib treated cells.
Supplemetary Video S4 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: April 2023

Video S4. MDA-MB231 cells on 3D-ECM generated by TGFÃŽÂ²-treated KO MEFs.
Supplemetary Video S1 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: April 2023

Video S1. MDA-MB231 cells on 3D-ECM generated by Control MEFs.
Supplementary Table S2 from Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway
Authors: Crowther Andrew J. , Ocasio Jennifer K. , Fang Fang , Meidinger Jessica , Wu Jaclyn , Deal Allison M. , Chang Sha X. , Yuan Hong , Schmid Ralf , Davis Ian , Gershon Timothy R.
Published: April 2023

List of published p53 targets identified by GRO-seq used for transcriptomic analysis.
Supplemental Figure S1 from Akt–Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression
Authors: Yamamura Yumiko , Asai Naoya , Enomoto Atsushi , Kato Takuya , Mii Shinji , Kondo Yuji , Ushida Kaori , Niimi Kaoru , Tsunoda Nobuyuki , Nagino Masato , Ichihara Shu , Furukawa Koichi , Maeda Kengo , Murohara Toyoaki , Takahashi Masahide
Published: April 2023

Effects of TGF-β1 stiumlation on α-SMA expression in fibroblasts isolated from WT and SA mice.
Supplemental Figure Legends from Glioblastomas Require Integrin αvβ3/PAK4 Signaling to Escape Senescence
Authors: Franovic Aleksandra , Elliott Kathryn C. , Seguin Laetitia , Camargo M. Fernanda , Weis Sara M. , Cheresh David A.
Published: April 2023

Supplemental Figure Legends
Supplemental Figure 4 from Glioblastomas Require Integrin αvβ3/PAK4 Signaling to Escape Senescence
Authors: Franovic Aleksandra , Elliott Kathryn C. , Seguin Laetitia , Camargo M. Fernanda , Weis Sara M. , Cheresh David A.
Published: April 2023

No co-localization of integrin β3 with phospho-PAK1
Supplemental Figure S2 from Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages
Authors: Wallerius Majken , Wallmann Tatjana , Bartish Margarita , Östling Jeanette , Mezheyeuski Artur , Tobin Nicholas P. , Nygren Emma , Pangigadde Pradeepa , Pellegrini Paola , Squadrito Mario Leonardo , Pontén Fredrik , Hartman Johan , Bergh Jonas , De Milito Angelo , De Palma Michele , Östman Arne , Andersson John , Rolny Charlotte
Published: April 2023

SEMA3AS EFFECT ON MONOCYTES AND MACROPHAGES.
Supplementary Legends for Supplementary Figures S1-S4 from Exploring the Biomechanical Properties of Brain Malignancies and Their Pathologic Determinants In Vivo with Magnetic Resonance Elastography
Authors: Jamin Yann , Boult Jessica K.R. , Li Jin , Popov Sergey , Garteiser Philippe , Ulloa Jose L. , Cummings Craig , Box Gary , Eccles Suzanne A. , Jones Chris , Waterton John C. , Bamber Jeffrey C. , Sinkus Ralph , Robinson Simon P.
Published: April 2023

Supplementary Legends for Supplementary Figures S1-S4.
Supplementary Figure S10 from Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial
Authors: Erdem-Eraslan Lale , van den Bent Martin J. , Hoogstrate Youri , Naz-Khan Hina , Stubbs Andrew , van der Spek Peter , Böttcher René , Gao Ya , de Wit Maurice , Taal Walter , Oosterkamp Hendrika M. , Walenkamp Annemiek , Beerepoot Laurens V. , Hanse Monique C.J. , Buter Jan , Honkoop Aafke H. , van der Holt Bronno , Vernhout René M. , Smitt Peter A.E. Sillevis , Kros Johan M. , French Pim J.
Published: April 2023

RNA seq can identify regions with LOH.
Supplementary Figure S1 from Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial
Authors: Erdem-Eraslan Lale , van den Bent Martin J. , Hoogstrate Youri , Naz-Khan Hina , Stubbs Andrew , van der Spek Peter , Böttcher René , Gao Ya , de Wit Maurice , Taal Walter , Oosterkamp Hendrika M. , Walenkamp Annemiek , Beerepoot Laurens V. , Hanse Monique C.J. , Buter Jan , Honkoop Aafke H. , van der Holt Bronno , Vernhout René M. , Smitt Peter A.E. Sillevis , Kros Johan M. , French Pim J.
Published: April 2023

Performance of DASL and RNA-seq on RNA isolated from FFPE tissues, technical replicates.
Supplementary Figure S2 from Exploring the Biomechanical Properties of Brain Malignancies and Their Pathologic Determinants In Vivo with Magnetic Resonance Elastography
Authors: Jamin Yann , Boult Jessica K.R. , Li Jin , Popov Sergey , Garteiser Philippe , Ulloa Jose L. , Cummings Craig , Box Gary , Eccles Suzanne A. , Jones Chris , Waterton John C. , Bamber Jeffrey C. , Sinkus Ralph , Robinson Simon P.
Published: April 2023

Supplementary Figure S2. Radiological presentation of intracranial U-87 MG, RG2 and MDA-MB-231 tumors.
Supplementary data from Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell–Mediated Antitumor Immunity
Authors: Brentville Victoria A. , Metheringham Rachael L. , Gunn Barbara , Symonds Peter , Daniels Ian , Gijon Mohamed , Cook Katherine , Xue Wei , Durrant Lindy G.
Published: April 2023

Supplementary figure 1-3 Supplementary tables 1 and 2 Supplementary data showing responses induced in mice from double and triple citrullinated vimentin aa28-49 peptides, murine aa415-433 peptide and evidence responses are not CD8 mediated as well as vimentin peptide sequences and cytokine data from human patient.
Supplementary Figure S5 from Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity
Authors: Zhao Weina , Prijic Sara , Urban Bettina C. , Tisza Michael J. , Zuo Yan , Li Lin , Tan Zhi , Chen Xiaoling , Mani Sendurai A. , Chang Jeffrey T.
Published: April 2023

ABCA1 drives metastasis in vivo.
Supplementary Figure S1 from Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin–GUCY2C Paracrine Signaling Axis
Authors: Lin Jieru E. , Colon-Gonzalez Francheska , Blomain Erik , Kim Gilbert W. , Aing Amanda , Stoecker Brian , Rock Justin , Snook Adam E. , Zhan Tingting , Hyslop Terry M. , Tomczak Michal , Blumberg Richard S. , Waldman Scott A.
Published: April 2023

Relative guanylin expression in proximal (PC) and distal (DC) colons of mice on lean or high fat (HF) diets.
Supplementary Figure Legend from Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin–GUCY2C Paracrine Signaling Axis
Authors: Lin Jieru E. , Colon-Gonzalez Francheska , Blomain Erik , Kim Gilbert W. , Aing Amanda , Stoecker Brian , Rock Justin , Snook Adam E. , Zhan Tingting , Hyslop Terry M. , Tomczak Michal , Blumberg Richard S. , Waldman Scott A.
Published: April 2023

Legend for Supplementary Figures S1-S7.
Supplementary Methods, Table 1, Figure S1-S9 from Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells
Authors: Cojoc Monica , Peitzsch Claudia , Kurth Ina , Trautmann Franziska , Kunz-Schughart Leoni A. , Telegeev Gennady D. , Stakhovsky Eduard A. , Walker John R. , Simin Karl , Lyle Stephen , Fuessel Susanne , Erdmann Kati , Wirth Manfred P. , Krause Mechthild , Baumann Michael , Dubrovska Anna
Published: April 2023

Supplementary Methods, Table 1, Figure S1-S9 (i) supplementary methods: Human tumor tissue dissociation, Immunofluorescence microscopy, Clonogenic cell survival assay, Sphere formation assay, Cell proliferation and cytotoxicity assay, Wound healing assay, Transwell migration assay, Western blot analysis, Flow cytometry analysis, Chromatin immunoprecipitation assay, siRNA-mediated gene silencing, Luciferase reporter assay, Histology, Microarray analysis of the xenograft tumors, (ii) supplementary table 1: Primary tumor tissues used in the study and (iii) supplementary figures including Figure S1 (analysis of ALDH1A1 expression in normal and tumor prostate tissues), Figure S2 (prostate cancer ALDH+ cells possess CSC properties), Figure S3 (analysis of CSC marker expression after irradiation), Figure S4 (clonogenicity and tumorigenisity of ALDH+ and ALDH- cells after irradiation), Figure S5 (characterization of the radioresistant prostate cancer cell sublines), Figure S6 (the mechanisms of prostate cancer cell radioresistance), Figure S7 (comparative gene expression profiling of ALDH+ and radioresistant DU145 cells), Figure S8 (EMT properties of ALDH+ and radioresistant prostate cancer cells), Figure S9 (WNT/β-catenin pathway regulates ALDH1A1 expression)
Supplementary Table S2 from Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo
Authors: Rao Shreyas S. , Bushnell Grace G. , Azarin Samira M. , Spicer Graham , Aguado Brian A. , Stoehr Jenna R. , Jiang Eric J. , Backman Vadim , Shea Lonnie D. , Jeruss Jacqueline S.
Published: April 2023

Sacrifice end points observed in the post-surgical model in the mock and scaffold groups with resection performed at day 10 without Gr-1 depletion.
Supplementary Figures from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation
Authors: Kasagi Yuta , Harada Yui , Morodomi Yosuke , Iwai Toshiki , Saito Satoru , Yoshida Kumi , Oki Eiji , Saeki Hiroshi , Ohgaki Kippei , Sugiyama Masahiko , Onimaru Mitsuho , Maehara Yoshihiko , Yonemitsu Yoshikazu
Published: April 2023

Supplementary Figure S1-7
Supplementary Methods and References from Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo
Authors: Rao Shreyas S. , Bushnell Grace G. , Azarin Samira M. , Spicer Graham , Aguado Brian A. , Stoehr Jenna R. , Jiang Eric J. , Backman Vadim , Shea Lonnie D. , Jeruss Jacqueline S.
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemantal Figures S1-S5 from GPCR Signaling Mediates Tumor Metastasis via PI3Kβ
Authors: Khalil Bassem D. , Hsueh Christine , Cao Yanyan , Abi Saab Widian F. , Wang Yarong , Condeelis John S. , Bresnick Anne R. , Backer Jonathan M.
Published: April 2023

Myc and p110α immunoblots in parental and stable cell lines (S1); Quantitation of immunoblots from Figure 1 (S2); Expression of GPCR-uncoupled or kinase-dead p110β in MDA-MB-231 cells has no effect on breast cancer cell proliferation (S3); Gβγ binding to p110β is required for macrophage-stimulated breast cancer cell migration (S4); Gβγ binding to p110β is required for macrophage-stimulated invasion in T47D cell line (S5).
Supplementary Table S2 from H3K27 Demethylase JMJD3 Employs the NF-κB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis
Authors: Park Woo-Yong , Hong Beom-Jin , Lee Jungsul , Choi Chulhee , Kim Mi-Young
Published: April 2023

A list of genes upregulated by JMJD3 in A375-LM3 cells.
Supplementary Figure S2 from H3K27 Demethylase JMJD3 Employs the NF-κB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis
Authors: Park Woo-Yong , Hong Beom-Jin , Lee Jungsul , Choi Chulhee , Kim Mi-Young
Published: April 2023

qRT-PCR analysis of JMJD3 candidate target genes.
Supplementary Figure S4 from ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Authors: Rodriguez Calleja Lidia , Jacques Camille , Lamoureux François , Baud'huin Marc , Tellez Gabriel Marta , Quillard Thibaut , Sahay Debashish , Perrot Pierre , Amiaud Jerome , Charrier Celine , Brion Regis , Lecanda Fernando , Verrecchia Franck , Heymann Dominique , Ellisen Leif W. , Ory Benjamin
Published: April 2023

The p63 and p73-controlled miR network regulates TGFÎ² induced migration.
Supplementary Figure S3 from ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Authors: Rodriguez Calleja Lidia , Jacques Camille , Lamoureux François , Baud'huin Marc , Tellez Gabriel Marta , Quillard Thibaut , Sahay Debashish , Perrot Pierre , Amiaud Jerome , Charrier Celine , Brion Regis , Lecanda Fernando , Verrecchia Franck , Heymann Dominique , Ellisen Leif W. , Ory Benjamin
Published: April 2023

p63 and p73 regulate SMAD4 and TÎ²RII.
Supplementary Figure S1 from ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Authors: Rodriguez Calleja Lidia , Jacques Camille , Lamoureux François , Baud'huin Marc , Tellez Gabriel Marta , Quillard Thibaut , Sahay Debashish , Perrot Pierre , Amiaud Jerome , Charrier Celine , Brion Regis , Lecanda Fernando , Verrecchia Franck , Heymann Dominique , Ellisen Leif W. , Ory Benjamin
Published: April 2023

p63-regulated microRNAs target the TGFÎ² pathway.
Supplementary Figure 4 from Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche
Authors: Giles Amber Jin , Reid Caitlin Marie , Evans Justin DeWayne , Murgai Meera , Vicioso Yorleny , Highfill Steven Lorenz , Kasai Miki , Vahdat Linda , Mackall Crystal Lee , Lyden David , Wexler Leonard , Kaplan Rosandra Natasha
Published: April 2023

Phenotypic and functionally immunosuppressive MDSCs in the primary tumor and spleen of tumor-bearing mice
Supplementary Materials and Methods from p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance
Authors: Yogev Orli , Barker Karen , Sikka Arti , Almeida Gilberto S. , Hallsworth Albert , Smith Laura M. , Jamin Yann , Ruddle Ruth , Koers Alexander , Webber Hannah T. , Raynaud Florence I. , Popov Sergey , Jones Chris , Petrie Kevin , Robinson Simon P. , Keun Hector C. , Chesler Louis
Published: April 2023

Supplementary Materials and Methods
Supplemental Figures from Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function
Authors: Wang Weihuan , Zimmerman Grant , Huang Xiaoran , Yu Shuiliang , Myers Jay , Wang Yiwei , Moreton Stephen , Nthale Joseph , Awadallah Amad , Beck Rose , Xin Wei , Wald David , Huang Alex Y. , Zhou Lan
Published: April 2023

Supplemental Figures. This file contains supplemental figures concerning analysis of megakaryocyte progenitor and erythroid progenitor analysis in the leukemia marrow, platelet and megakaryocyte progenitor analysis after DBZ treatment of leukemia mice, as well as CXCL12 promoter CHIP analysis
Supplemental Figure 1 from STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis
Authors: Jones Laura M. , Broz Miranda L. , Ranger Jill J. , Ozcelik John , Ahn Ryuhjin , Zuo Dongmei , Ursini-Siegel Josie , Hallett Michael T. , Krummel Matthew , Muller William J.
Published: April 2023

Supplemental Figure 1: Confirmation of specific Stat3 ablation in the epithelium.
Supplementary Table 2 from Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression
Authors: da Silva-Diz Victoria , Simón-Extremera Pilar , Bernat-Peguera Adrià , de Sostoa Jana , Urpí Maria , Penín Rosa M. , Sidelnikova Diana Pérez , Bermejo Oriol , Viñals Joan Maria , Rodolosse Annie , González-Suárez Eva , Moruno Antonio Gómez , Pujana Miguel Ángel , Esteller Manel , Villanueva Alberto , Viñals Francesc , Muñoz Purificación
Published: April 2023

Table S2. List of differentially expressed genes between E-CSCs and L-CSCs, which were isolated from WD-SCCs and PD/S-SCCs, respectively.
Supplementary Figures 1 through 7, Supplementary Tables 1 and 3, and Supplementary Materials and Methods from Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression
Authors: da Silva-Diz Victoria , Simón-Extremera Pilar , Bernat-Peguera Adrià , de Sostoa Jana , Urpí Maria , Penín Rosa M. , Sidelnikova Diana Pérez , Bermejo Oriol , Viñals Joan Maria , Rodolosse Annie , González-Suárez Eva , Moruno Antonio Gómez , Pujana Miguel Ángel , Esteller Manel , Villanueva Alberto , Viñals Francesc , Muñoz Purificación
Published: April 2023

Figure S1. Generation and characterization of orthotopic SCC lineages. Figure S2. Analysis of CSC frequency and EMT induction during SCC progression. Figure S3. Characterization of primary culture cells derived of WD-SCCs and PD/S-SCCs. Figure S4. Activation of autocrine PDGFRα signaling in PD/S-SCCs. Figure S5. In vitro and in vivo assays showing that the inhibition of PDGFRα signaling does not affect the frequency of CSCs, EMT or PD/S-SCC growth. Figure S6. Activation of autocrine FGFR1 signaling in PD/S cells. Figure S7. L-CSC signature identifies advanced and poor-prognosis human lung and head-neck SCCs. Table S1. Histopathological features of distinct primary and orthotopically-derived SCCs (SCC lineages) at different passages. Table S3. List of human skin SCCs samples used in this study. Histopathological features of these samples are described. Supplementary Materials and Methods.
Supplementary Figure S11 from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: April 2023

Validation of CIS genes in vivo.
Supplementary Table S5 from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: April 2023

The signaling pathways and biological processes of the mutated genes in 6 HCC tissues
Supplementary Figure 4 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: April 2023

STAT1 and STAT6 downstream gene expression
Supplementary Figure 2 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: April 2023

Flow cytometric analysis of leukocyte infiltration in tumor tissue
CTL CD103+ treated TGF-β on r-Ecadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Authors: Boutet Marie , Gauthier Ludiane , Leclerc Marine , Gros Gwendoline , de Montpreville Vincent , Théret Nathalie , Donnadieu Emmanuel , Mami-Chouaib Fathia
Published: April 2023

CTL CD103+ treated TGF-β on r-Ecadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
CTL CD103+ on rE-cadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Authors: Boutet Marie , Gauthier Ludiane , Leclerc Marine , Gros Gwendoline , de Montpreville Vincent , Théret Nathalie , Donnadieu Emmanuel , Mami-Chouaib Fathia
Published: April 2023

CTL CD103+ on rE-cadh-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Supplemental Fig.S1. from HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy
Authors: Liu Tongzheng , Fang Yuan , Zhang Haoxing , Deng Min , Gao Bowen , Niu Nifang , Yu Jia , Lee SeungBaek , Kim JungJin , Qin Bo , Xie Fang , Evans Debra , Wang Liewei , Lou Wenhui , Lou Zhenkun
Published: April 2023

Supplemental Fig.S1. HEATR1 regulates cancer cell response to chemotherapy
Supplemental Data from HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy
Authors: Liu Tongzheng , Fang Yuan , Zhang Haoxing , Deng Min , Gao Bowen , Niu Nifang , Yu Jia , Lee SeungBaek , Kim JungJin , Qin Bo , Xie Fang , Evans Debra , Wang Liewei , Lou Wenhui , Lou Zhenkun
Published: April 2023

Supplemental data includes supplement materials, methods and data
Supplementary Table 1 from Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth
Authors: Pathania Rajneesh , Ramachandran Sabarish , Mariappan Gurusamy , Thakur Priyanka , Shi Huidong , Choi Jeong-Hyeon , Manicassamy Santhakumar , Kolhe Ravindra , Prasad Puttur D. , Sharma Suash , Lokeshwar Bal L. , Ganapathy Vadivel , Thangaraju Muthusamy
Published: April 2023

Supplementary table 1 will provide a complete list of genes that are differentially regulated genes in RNA-seq analysis for control and 5-AzaC+Butyrate treated CSCs
Supplementary Figures 1 and 2 from Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells
Authors: Casimiro Mathew C. , Di Sante Gabriele , Ju Xiaoming , Li Zhiping , Chen Ke , Crosariol Marco , Yaman Ismail , Gormley Michael , Meng Hui , Lisanti Michael P. , Pestell Richard G.
Published: April 2023

Endogenous cyclin D1 promotes LNCaP cell proliferation and DNA synthesis (S1); The epithelial population in Cyclin D1+/+ PECs is predominantly composed of luminal CK8+ cells (S2).
legends of supplemental figures from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

legends of all supplemental figures
Supplementary Table 7 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: April 2023

Supplementary Table 7. Ischemia regulated pTyr sites in {greater than or equal to} 3 patients
Table S4 from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

Sequence of the primers used for PCR.
Supplementary Table 5 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: April 2023

Supplementary Table 5. Summary of colon tumor iTRAQ LC-MS/MS protein expession analysis
HBEC-3 2D-migration induced by RASS1A-knockdown from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

HBEC-3 2D-migration induced by RASS1A-knockdown showed features evoking both collective migration and multicellular streaming
Supplementary Table 2 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: April 2023

Supplementary Table 2. Basal state of ovarian tumor samples
Supplementary Table 1 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: April 2023

Supplementary Table 1. Ovarian pTyr ischemia response
Figure S8: RhoA activity is not influenced by RASSF1A depletion whereas constitutive activation of a Rho activity by Narciclasine still impairs RASSF1A-induced invasion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

A) GST pull-down assay in HBEC-3 cells. Quantification of active GTP-bound RhoA levels as determined by western blotting. One representative experiment is shown in a top panel of histogram. B & C) HBEC-3 cells were transiently transfected with non-silencing siRNA (siNeg), siRASSF1A-1 in combination or not with B) three plasmids coding for wt-RhoA, RhoA N19 (dominant negative form) & RhoAV14 (constitutively active form) C) Cells were assayed for their invasive capacities with Narciclasine treatment. The invasion capacity was assessed using a BioCoat Matrigel Invasion Chamber. The relative invasion was normalized to that of the cells transfected with siNeg. D) Nuclear intensity of YAP was assessed by immunofluorescence and confocal microscopy (right panel), upon depletion of RASSF1A, transfection of RhoAwt expressing plasmid, co-transfection of siRASSF1A and RhoAwt plasmid, transfection of dominant negative RhoAN19 plasmid alone, or upon RASSF1A depletion, transfection of constitutively active RhoAV14 plasmid alone or upon RASSF1A depletion. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01 and ***p<0.001, using an ANOVA test followed by Dunnett's test. E) PP1 protein expression assessed by western-blot upon RASS1A depletion or RASSF1A and 1C depletion. Error bars in histograms indicate the standard error of the mean (SEM) of at least three independent experiments. F) One representative experiment of PP2ACalpha Immunoprecipitation is shown in BEAS-2B cells grew exponentially, followed by PP2ACalpha or RhoB western-blottings, with corresponding specific antibodies. G) Representative images for Ser885-phosphoGEF-H1 staining assessed by immunofluorescence and confocal microscopy, upon RASSF1A, PP2ACalpha, RhoB or GEF-H1 depletion. The cells were stained by Ser885-phosphoGEF-H1 primary antibody (Green) followed by Alexa488 conjugated secondary antibody, along with DAPI for DNA (Blue). H) Quantification of ANKDR1 & CTGF mRNA using actin as an internal control.
Methods and Supplementary Figures 1-9 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: April 2023

Methods and Supplementary Figures 1-9. Supplementary Figure 1: Histopathology images of tumors used in ischemia time-course and spatial heterogeneity experiments. Supplementary Figure 2: Schematic overview of ovarian tumor ischemia time-course experiment. Supplementary Figure 3: Distinct inter-patient ischemia regulated temporal dynamics are observed. Supplementary Figure 4: Similar ischemia response temporal patterns are observed across ovarian tumors. Supplementary Figure 5: Schematic overview of the colon tumor spatial heterogeneity and ischemia time-course experiment. Supplementary Figure 6: Spatial phosphorylation heterogeneity in colons tumors cannot be attributed solely to technical measurement error. Supplementary Figure 7: Weak correlations and minimal shared covariance between spatially proximal colon tumor samples. Supplementary Figure 8: Schematic overview of the colon tumor protein expression profiling experiment. Supplementary Figure 9: Delayed freezing of tumors affects pTyr sites involved in numerous pathways and processes.
Figure S6. sh-mediated RASSF1A depletion in HBEC-3 cells. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

HBEC-3 cells were transfected with non-silencing shRNA (Control), shRASSF1A-777 and shRASSF1A-779. A) Changes in RASSF1A and Yap expression assessed by immunofluorescence (Red=RASSF1A, Green=Yap, Blue=DAPI) experiments. Scale bar represents 50 µm. B) The migration speed (µm/h) of transfected cells was determined by wound assay on collagen IV. Mitomycin C (1 µg/ml) was added to medium 12h before wounding. The invasion capacity was assessed using a BioCoat Matrigel Invasion Chamber. The relative invasion was normalized to that of the cells transfected with Control. C) Representative images of colony formation of transfected cells in soft agar. Scale bar represents 20 µm. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01 and ***p<0.001, using an ANOVA test followed by Dunnett's test.
Figure S4: trans-endothelial invasion, enhanced-migration and growth in soft agar upon RASSF1A depletion in 4 transformed and untransformed epithelial bronchial cell lines. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

The cells were transiently transfected with siNeg, siRASSF1A or siRASSF1AC. The experiences were performed 48 hours after transfection A. The trans-endothelial invasion capacity of transfected cells was assessed using a cell culture insert (BioCoat Matrigel Invasion Chamber) on which a monolayer of endothelial cells has been grown previously. The total number of cells that invaded to the lower side of the filter after 48h was counted under the microscope (10X). The relative invasion was normalized to that of the cells transfected with siNeg. B. The migration speed (µm/h) of transfected HBEC-3 RasV12, H1975 and BEAS-2B cells was determined by wound healing assay on Fibronectin (HBEC-3) or collagen IV (H1975 and BEAS-2B). Mitomycin C (1 µg/ml) was added to medium 12h before wounding. C. The invasion capacity of transfected HBEC-3RasV12, H1975, BEAS-2B, BEAS-2B RasV12 cells was assessed using BioCoat Matrigel Invasion Chambers. The total number of cells that invaded to the lower side of the filter after 48h was counted under the microscope (10X). The relative invasion was normalized to that of the cells transfected with siNeg. D. The capacity of growth without adherence in soft agar of HBEC-3 RasV12 and BEAS-2B cells transfected by an inactive siRNA or SiRASSF1A was evaluated by quantification of colony formation. The number of colonies was scored after 7 days. One representative experiment is shown in a right panel. Scale bar represents 80 µm. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01 and ***p<0.001, using an ANOVA test followed by Dunnett's test.
Figure S2: Depletion of RASSF1A alone or with RASSF1C results in disappearance of tight junctions and decrease of adherens junction, replaced by diffuse adherent junctions. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

Three independent air-liquid cultures, each requiring 21 days of growth before fixation and observation, were analyzed. For each culture, 2 slides through the porous membrane and the cells have been performed, those slides being processed at the center of the membrane to avoid artifacts linked to a peripheral location. For siNeg condition (only one stratum of cells) 50 to 70 cells were observed, whereas for siRASSF1A conditions, 50 to 250 cells (several strata of cells) were analyzed. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01, using an ANOVA test followed by Dunnett's test.
Supplemental Figure S5 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Authors: Giraud Julie , Failla Laura M. , Pascussi Jean-Marc , Lagerqvist Ebba L. , Ollier Jérémy , Finetti Pascal , Bertucci François , Ya Chu , Gasmi Imène , Bourgaux Jean-François , Prudhomme Michel , Mazard Thibault , Ait-Arsa Imade , Houhou Leila , Birnbaum Daniel , Pélegrin André , Vincent Charles , Ryall James G. , Joubert Dominique , Pannequin Julie , Hollande Frédéric
Published: April 2023

Promotion of a glycolytic profile by progastrin is essential for the self-renewal ability of ALDHhigh cells.
Supplementary Table 2 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: April 2023

ROS/RNS induction by IT-­901 treatement in normal tissues.
Supplementary Table 1 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: April 2023

IT-901 has no significant adverse effects on major organ functions and blood cell counts.
Supplementary Figure 9 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: April 2023

IT-901 mediates anti-lymphoma activity in a xenograft model of EBV-induced lymphoma.
Supplementary Figure 8 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: April 2023

c-Rel is constitutively active in a wide range of human lymphoma types.
Supplemental Materials and Methods from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
Authors: Ohashi Yoshimi , Okamura Mutsumi , Hirosawa Asaka , Tamaki Naomi , Akatsuka Akinobu , Wu Kuo-Ming , Choi Hyeong-Wook , Yoshimatsu Kentaro , Shiina Isamu , Yamori Takao , Dan Shingo
Published: April 2023

Supplemental Materials and Methods for "Authentication of cell lines"
Supplemental Figure Legends from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
Authors: Ohashi Yoshimi , Okamura Mutsumi , Hirosawa Asaka , Tamaki Naomi , Akatsuka Akinobu , Wu Kuo-Ming , Choi Hyeong-Wook , Yoshimatsu Kentaro , Shiina Isamu , Yamori Takao , Dan Shingo
Published: April 2023

Supplemental Figure Legends