bluuebunny/crossref_metadata_2025 huggingface dataset:
Calibration Method of Measuring Heads for Testing Residual Stresses in Sheet Metal Using the Barkhausen Method
Authors: Garstka Tomasz , Szota Piotr , Mróz Sebastian , Stradomski Grzegorz , Gróbarczyk Jakub , Gryczkowski Radosław
Published: September 2024

Among non-destructive testing methods, a group dedicated to the assessment of the state of residual stresses can be distinguished. The method of measuring residual stresses using the Barkhausen noise method has many advantages, as evidenced by the number of publications. The residual stresses in metal products are important for the further processing of such metal, such as laser cutting or bending. The results presented in this work are of an experimental nature, and the presented method of calibration of measuring heads shows how various research techniques can be used to correlate results. The research was carried out for structural steel due to the market share of this type of steel. The method can be used to measure the residual stresses in ferromagnetic metal products in order to assess their directions and quantify them. A prerequisite for the use of this measurement method is that the amplitude and geometry of the Barkhausen noise are adequately correlated to the specific values of the state of stress depending on the tested steel grade or other metals. In this study, a method for calibrating measuring sensors for the residual stress measurements is presented, as developed by the authors. The method involved conducting bending tests in both numerical modeling and experimental tests. During the bending tests, changes in the magnetic field (Barkhausen noise waveform) were recorded, taking into account the state of elastic stresses. Correlating the results of the numerical calculations and Barkhausen noise measurements made it possible to determine the quantitative values of the residual stresses in the steel sheets. Thanks to the method used, very accurate measurement is possible, and the obtained results are repeatable.
Experimental Study on the Frost Resistance of Basalt Fiber Reinforced Concrete
Authors: Guo Yihong , Gao Jianlin , Lv Jianfu
Published: September 2024

In this paper, the effect of basalt fiber (BF) on the frost resistance of concrete under different curing conditions was investigated, and its frost resistance mechanism was analyzed. Three different curing conditions (normal curing, short-term curing, and seawater curing) were adopted, and concrete with different BF volume contents was designed. Freeze-thaw (FT) tests were carried out using the rapid freezing method to test the frost resistance of basalt fiber reinforced concrete (BFRC). Additionally, the mass loss rate (MLR), relative dynamic modulus of elasticity (RDME) change, and compressive strength reduction of specimens during the freeze-thaw cycles (FTCs) were evaluated. The results show that when the BF content is 0.15%, under normal curing, short-term curing, and seawater curing conditions, the residual compressive strength of BFRC after FTCs was increased by 5.4%, 28.1%, and 30.9%, respectively, compared to plain concrete. By incorporating BF into concrete, the development of microcracks can be effectively retarded, and damage generation during FTCs can be reduced. In addition, the microscopic morphological characteristics and pore structure characteristics of concrete further elucidate the frost resistance mechanism of BFRC from a microscopic perspective.
Modulating Carbon Fiber Surfaces with Vinyltriethoxysilane Grafting to Enhance Interface Properties of Carbon Fiber/Norbornene–Polyimide Composites
Authors: Feng Jianshun , Kong Guoqiang , Shao Meng , Yu Qiubing , Yu Guang , Ren Xin , Yuan Wenjie , Liu Wenbo , Wang Xinyu , Wang Kang , Li Dayong , Di Chengrui , Zhu Bo
Published: September 2024

In this study, vinyltriethoxysilane (TEVS) was introduced onto the surface of carbon fiber using liquid-phase oxidation and impregnation methods to incorporate vinyl groups onto the carbon fiber, thereby enhancing the chemical bonding between the carbon fiber and norbornene–polyimide (PI-NA). Through a systematic study of the hydrolysis conditions and concentration of the TEVS solution, the optimal modification conditions were determined. These conditions were used to graft TEVS onto the surface of oxidized carbon fiber to prepare carbon-fiber-reinforced PI-NA composites (CF/PI-NA). The results show that when carbon fiber was treated with a 0.4 wt% TEVS solution, the interlaminar shear strength (ILSS) of the composites reached 65.12 MPa, and the interfacial shear strength (IFSS) reached 88.58 MPa, representing increases of 27.58% and 35.62%, respectively, compared to the CF/PI-NA composite materials prepared from untreated carbon fiber. It is worth noting that the modification method described in the study is simple and easy to implement, and it has the potential for large-scale continuous production applications.
Effect of Proton Irradiation on Thin-Film YBa2Cu3O7−δ Superconductor
Authors: Fogt Joseph , Weeda Hope , Harrison Trevor , Miles Nolan , Cho Kyuil
Published: September 2024

We investigated the effect of 0.6 MeV proton irradiation on the superconducting and normal-state properties of thin-film YBa2Cu3O7−δ superconductors. A thin-film YBCO superconductor (≈567 nm thick) was subject to a series of proton irradiations with a total fluence of 7.6×1016 p/cm2. Upon irradiation, Tc was drastically decreased from 89.3 K towards zero with a corresponding increase in the normal-state resistivity above Tc. This increase in resistivity, which indicates an increase in defects inside the thin-film sample, can be converted to the dimensionless scattering rate. We found that the relation between Tc and the dimensionless scattering rate obtained during proton irradiation approximates the generalized d-wave Abrikosov–Gor’kov theory better than the previous results obtained from electron irradiations. This is an unexpected result, since the electron irradiation is known to be most effective to suppress superconductivity over other heavier ion irradiations such as proton irradiation. In comparison with the previous irradiation studies, we found that the result can be explained by two facts. First, the dominant defects created by 0.6 MeV protons can be point-like when the implantation depth is much longer than the sample thickness. Second, the presence of defects on all element sites is important to effectively suppress Tc.
Reliability Modeling of Systems with Undetected Degradation Considering Time Delays, Self-Repair, and Random Operating Environments
Authors: Pham Hoang
Published: September 2024

In some settings, systems may not fail completely but instead undergo performance degradation, leading to reduced efficiency. A significant concern arises when a system transitions into a degraded state without immediate detection, with the degradation only becoming apparent after an unpredictable period. Undetected degradation can result in failures with significant consequences. For instance, a minor crack in an oil pipeline might go unnoticed, eventually leading to a major leak, environmental harm, and costly cleanup efforts. Similarly, in the nuclear industry, undetected degradation in reactor cooling systems could cause overheating and potentially catastrophic failure. This paper focuses on reliability modeling for systems experiencing degradation, accounting for time delays associated with undetected degraded states, self-repair mechanisms, and varying operating environments. The paper presents a reliability model for degraded, time-dependent systems, incorporating various aspects of degradation. It first discusses the model assumptions and formulation, followed by numerical results obtained from system modeling using the developed program. Various scenarios are illustrated, incorporating time delays and different parameter values. Through computational analysis of these complex systems, we observe that the probability of the system being in the undetected degraded state tends to stabilize shortly after the initial degradation begins. The model is valuable for predicting and establishing an upper bound on the probability of the undetected, degraded state and the system’s overall reliability. Finally, the paper outlines potential avenues for future research.
Prevalence and Characteristics of Isolated Nighttime Masked Uncontrolled Hypertension in Treated Patients
Authors: Kim Kang Hee , Chung Jaehoon , Jang Suyoung , Kim Byong-Kyu , Munakata Masanori , Rhee Moo-Yong
Published: September 2024

Background and Objectives: We evaluated the prevalence and characteristics of isolated nighttime masked uncontrolled hypertension (IN-MUCH) in treated patients. Materials and Methods: Participants aged 20 years or older who were on antihypertensive medication underwent three-day office blood pressure (BP) and 24 h ambulatory BP measurements. Hypertension phenotypes were classified as controlled hypertension (CH), isolated daytime masked uncontrolled hypertension (ID-MUCH), IN-MUCH, and daytime and nighttime masked uncontrolled hypertension (DN-MUCH). Results: Among 701 participants, 544 had valid BP data and controlled office BP (<140/90 mmHg). The prevalence of IN-MUCH was 34.9%, with a higher prevalence of men and drinkers than in those with CH. Patients with IN-MUCH had higher office systolic BP (SBP) and diastolic BP (DBP) than those with CH. The prevalence of IN-MUCH was 37.6%, 38.5%, and 27.9% in patients with optimal, normal, and high-normal office BP levels, respectively. Among IN-MUCH patients, 51.6% exhibited isolated uncontrolled DBP and 41.1% uncontrolled SBP and DBP. Younger age (p = 0.043), male sex (p = 0.033), and alcohol consumption (p = 0.011) were more prevalent in patients with isolated uncontrolled DBP than in those with uncontrolled SBP and DBP. Age and alcohol consumption were positively associated, whereas high-normal office BP exhibited a negative association with IN-MUCH. Conclusions: The IN-MUCH was significantly more prevalent in patients with normal or optimal office BP, posing treatment challenges. Further investigation is needed to determine whether differentiation between isolated uncontrolled DBP and combined uncontrolled SBP and DBP is necessary for prognostic assessment of IN-MUCH.
Influence of Ironing Roller on the Wrinkling of a 4N6 Aluminum Foil during the Coiling Process of Cleaning Line
Authors: Zuo Xiaogang , Lv Zhimin
Published: September 2024

Ironing roll is vital equipment in the production of wide aluminum foil, which has a significant impact on the wrinkling defects of aluminum foil during the winding process of the cleaning production line. In this paper, wrinkling defects in 4N6 aluminum foils were improved using the ABAQUS finite element software 2020. A dynamic simulation model of the aluminum foil winding process was established. The ethics model first analyzed the causes of wrinkling during the aluminum foil coiling process. Then the influence of each factor on aluminum foil wrinkling was studied for the effect of ironing pressure, ironing roll deviation, the friction coefficient between the ironing roll and the aluminum foil, and the shape of the ironing roll on the wrinkling of the aluminum foil. The friction coefficients between aluminum foil coils and the uneven distribution of coiling tension have different effects on the wrinkling of aluminum foil. By selecting the optimal process parameters, it is possible to improve the forming quality of the aluminum foil sheet and to reduce the wrinkling faults in the winding process.
Sintering Mechanism and Leaching Kinetics of Low-Grade Mixed Lithium Ore and Limestone
Authors: Fu Wanying , Meng Long , Qu Jingkui
Published: September 2024

With the rapid development of new energy fields and the current shortage of lithium supply, an efficient, clean, and stable lithium resource extraction process is urgently necessary. In this paper, various advanced detection methods were utilized to conduct a mineralogical analysis of the raw ore and systematically study the occurrence state of lithium; the limestone sintering process was strengthened and optimized, elucidating the sintering mechanism and analyzing the leaching process kinetics. Under an ingredient ratio of 1:3, a sample particle size of 300 mesh, a sintering temperature of 1100 °C, a sintering time of 3 h, a liquid–solid ratio of 2:1, a leaching temperature of 95 °C, and a leaching time of 1 h, the leaching rate of Li reached 90.04%. The highly active Ca–O combined with Si–O on the surface of β–spodumene to CaSiO4, and Al–O was isolated and combined with Li to LiAlO2, which was beneficial for the leaching process. The leaching process was controlled by both surface chemical reactions and diffusion processes, and Ea was 27.18 kJ/mol. These studies provide theoretical guidance for the subsequent re-optimization of the process.
Kinetics of Iron Collector Leaching in HCl and HF Media
Authors: Kuzas Evgeniy , Sandalov Ivan , Karimov Kirill , Kritskii Aleksei , Fomenko Ilia , Zhidkov Ivan , Abramov Aleksandr
Published: September 2024

Automotive catalysts containing Platinum Group Metals (PGMs) are valuable secondary raw materials for refineries. Hydrometallurgical processing of catalysts is ineffective due to the low PGMs content—0.15–0.3%. Therefore, such raw materials are melted into an iron collector containing 1.5–5% PGMs. However, when leaching a collector containing 10–20% Si in both HCl and H2SO4, the recovery of PGMs does not exceed 40%. The latter indicates incomplete destroying of the PGM-encapsulating ferrosilicon matrix. To completely destroy the ferrosilicon matrix, it is proposed to carry out the leaching process in a mixture of HCl and HF. In this case, the extraction of Fe into solution and Si into the gas phase (in the form of SiF4) exceeds 90%. This should be sufficient to completely destroy the ferrosilicon matrix and release PGMs. The current work presents the results of studies of the leaching kinetics of the iron collector containing ferrosilicon in a mixture of HCl and HF using the Shrinking Core Model (SCM). It was found that the greatest positive effect on Fe extraction into solution is exerted by HCl concentration and temperature, while Si release into the gas phase is only influenced by HF concentration. In addition, during the destroying of ferrosilicon, FeF2 is formed and deposited on the surface of the material in the form of thin-film conglomerates. This leads to diffusion difficulties and a gradual decrease in the intensity of the iron collector leaching 30 min after the start of process. After 120 min, there may be a decrease in Fe recovery into solution.
Exploration of a Novel Electric-Fuse Device with a Simple Structure of Ni Metal on a SiO2 Dielectric for Electrostatic Discharge Protection under a Human Body Model
Authors: Guan He , Li Jiaying , Chen Yangchao , Tang Yongchuan , Li Yunshuo
Published: September 2024

On-chip electrostatic discharge (ESD) protection poses a challenge in the chip fabrication process. In this study, a novel electric fuse (E-fuse) device featuring a simple structure of Ni metal on a SiO2 dielectric for ESD protection was proposed, and the physical mechanism of its operation was investigated in detail. Experimental evaluations, utilizing transmission line pulse (TLP) testing and fusing performance analyses, reveal that the E-fuse, constructed with a Ni metal layer measuring 5 μm in width, 100 μm in length, and 5 nm in thickness, achieved a significant ESD protection voltage of 251 V (VHBM) and demonstrates low-voltage fusing at a bias voltage of 7 V. Compared to traditional ESD protection devices, the E-fuse boasts a smaller size and removability. To assess fusing performance, devices of varying sizes were tested using a fusing lifetime model. This study supports both theoretical and empirical evidence, enabling the adoption of cost-effective, straightforward E-fuse devices for ESD protection.
The Effect of Weathering Conditions in Combination with Natural Phenomena/Disasters on Microplastics’ Transport from Aquatic Environments to Agricultural Soils
Authors: Belioka Maria-Paraskevi , Achilias Dimitrios S.
Published: September 2024

Concern over microplastics (MPs) in the environment is rising. Microplastics are generally known to exist in aquatic settings, but less is known about their occurrence in soil ecosystems. When plastic waste builds up in agricultural areas, it can have a negative impact on the environment and food sources, as well as have an indirect effect on all trophic levels of the food chain. This paper addresses the relationship between microplastics and the management of plastic waste, which contributes to their accumulation, and it describes the sources and the movement processes of microplastics in agricultural soils as a result of natural events and disasters. Evaluating the impact of weather on coastal microplastic contamination is critical, as extreme weather events have become more frequent in recent years. This study sheds light on how weather patterns affect the dispersion of plastic waste in terrestrial habitats, including the impacts of seasonality and extreme weather. According to the results of this review, typhoons, monsoons, rainfall, and floods contribute significantly more microplastics to the surface sediment through surface runoff and wind transport, particle redistribution caused by agitated waves, and fragmentation under intense abrasion forces. Severe weather conditions have the potential to disperse larger and more varied kinds of microplastics.
Tuning the Charge Transfer in MWCNTs via the Incorporation of ZnONPs and AgNPs: The Role of Carbon Binding with ZnO/Ag Heterostructures in Reactive Species Formation
Authors: Gamiño-Barocio Ismael , Vázquez-Vázquez Eric Fernando , Hernández-Rodríguez Yazmín Mariela , Cigarroa-Mayorga Oscar Eduardo
Published: September 2024

In this research, multi-walled carbon nanotubes (MWCNTs) were decorated with two kinds of nanostructures, (1) silver nanoparticles (AgNPs) and (2) zinc oxide–silver nano-heterostructures (ZnO/Ag-NHs), via an accessible chemical coprecipitation method assisted with ultrasonic radiation. The high-resolution transmission electron microscopy analysis demonstrated the successful decoration of MWCNTs with the nanostructures with a diameter size of 11 nm ± 2 nm and 46 nm ± 5 nm for the AgNPs and the ZnO/Ag-NHs, respectively. The reactive species were promoted in an aqueous medium assisted with UV irradiation on the functionalized MWCNT. UV-Vis spectroscopy demonstrated that production of the reactive species density increased 4.07 times, promoted by the single MWCNT after the functionalization. X-ray photoelectron spectroscopy showed that Sp2 hybridization in carbon atoms of MWCNTs participates in the binding of AgNPs and ZnO/Ag-NH decoration and thus participates in the formation of reactive species in an aqueous medium, as is the case for cancer cells.
Vortex Domain Wall Thermal Pinning and Depinning in a Constricted Magnetic Nanowire for Storage Memory Nanodevices
Authors: Al Bahri Mohammed , Al-Kamiyani Salim , Al Habsi Al Maha
Published: September 2024

In this study, we investigate the thermal pinning and depinning behaviors of vortex domain walls (VDWs) in constricted magnetic nanowires, with a focus on potential applications in storage memory nanodevices. Using micromagnetic simulations and spin transfer torque, we examine the impacts of device temperature on VDW transformation into a transverse domain wall (TDW), mobility, and thermal strength pinning at the constricted area. We explore how thermal fluctuations influence the stability and mobility of domain walls within stepped nanowires. The thermal structural stability of VDWs and their pinning were investigated considering the effects of the stepped area depth (d) and its length (λ). Our findings indicate that the thermal stability of VDWs in magnetic stepped nanowires increases with decreasing the depth of the stepped area (d) and increasing nanowire thickness (th). For th ≥ 50 nm, the stability is maintained at temperatures ≥ 1200 K. In the stepped area, VDW thermal pinning strength increases with increasing d and decreasing λ. For values of d ≥ 100 nm, VDWs depin from the stepped area at temperatures ≥ 1000 K. Our results reveal that thermal effects significantly influence the pinning strength at constricted sites, impacting the overall performance and reliability of magnetic memory devices. These insights are crucial for optimizing the design and functionality of next-generation nanodevices. The stepped design offers numerous advantages, including simple fabrication using a single electron beam lithography exposure step on the resist. Additionally, adjusting λ and d allows for precise control over the pinning strength by modifying the dimensions of the stepped areas.
Exploring the Wound Healing Potential of Hispidin
Authors: Liu Yi-Shan , Lai Mei-Chou , Hong Tang-Yao , Liu I-Min
Published: September 2024

Background: Hispidin, a polyphenol component mainly derived from the medicinal mushroom species Phellinus and Inonotus, shows promise for biomedical applications, yet its potential in wound healing remains largely unexplored. This research investigates the wound healing effects of hispidin through in vitro and in vivo experiments, while also evaluating its antimicrobial properties and safety profile. Methods: In vitro scratch assays were conducted to evaluate the impact of hispidin on the migration of NIH-3T3 cells. The wound healing potential of hispidin was assessed in rats using excision wounds, dead space wounds, and linear incisions, treated with various topical ointments including a simple ointment, 2.5% (w/w) and a 5% (w/w) hispidin ointment, and a 0.2% (w/w) nitrofurazone ointment, administered at 0.2 g daily for 14 days. Results: Hispidin demonstrated antimicrobial properties and was particularly effective against Staphylococcus epidermidis. Hispidin enhanced NIH-3T3 cell viability, and promoted wound closure in scratch assays, correlating with increased levels of FGF21, TGF-β1, EGF, and VEGF. In excision wound models, the 5% (w/w) hispidin ointment improved wound contraction, epithelialization, tissue regeneration, fibroblast activity, and angiogenesis. In the granulation tissue from dead space wound models, hispidin reduced pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and lipid peroxidation, while increasing anti-inflammatory cytokines (IL-10) and antioxidant activities (SOD, GPx, CAT), along with connective tissue markers like hydroxyproline, hexosamine, and hexuronic acid. Hispidin also enhanced wound breaking strength in incision models. Acute dermal toxicity studies indicated no adverse effects at 2000 mg/kg. Conclusions: These findings highlight hispidin’s potential in wound care, demonstrating its antimicrobial, regenerative, and safety properties.
Capsaicin Improves Systemic Inflammation, Atherosclerosis, and Macrophage-Derived Foam Cells by Stimulating PPAR Gamma and TRPV1 Receptors
Authors: Ávila Danielle Lima , Fernandes-Braga Weslley , Silva Janayne Luihan , Santos Elandia Aparecida , Campos Gianne , Leocádio Paola Caroline Lacerda , Capettini Luciano Santos Aggum , Aguilar Edenil Costa , Alvarez-Leite Jacqueline Isaura
Published: September 2024

Background: Capsaicin, a bioactive compound found in peppers, is recognized for its anti-inflammatory, antioxidant, and anti-lipidemic properties. This study aimed to evaluate the effects of capsaicin on atherosclerosis progression. Methods: Apolipoprotein E knockout mice and their C57BL/6 controls were utilized to assess blood lipid profile, inflammatory status, and atherosclerotic lesions. We also examined the influence of capsaicin on cholesterol influx and efflux, and the role of TRPV1 and PPARγ signaling pathways in bone marrow-derived macrophages. Results: Capsaicin treatment reduced weight gain, visceral adiposity, blood triglycerides, and total and non-HDL cholesterol. These improvements were associated with a reduction in atherosclerotic lesions in the aorta and carotid. Capsaicin also improved hepatic oxidative and inflammatory status. Systemic inflammation was also reduced, as indicated by reduced leukocyte rolling and adhesion on the mesenteric plexus. Capsaicin decreased foam cell formation by reducing cholesterol influx through scavenger receptor A and increasing cholesterol efflux via ATP-binding cassette transporter A1, an effect primarily linked to TRPV1 activation. Conclusions: These findings underscore the potential of capsaicin as a promising agent for atherosclerosis prevention, highlighting its comprehensive role in modulating lipid metabolism, foam cell formation, and inflammatory responses.
Maternal Polyphenols and Offspring Cardiovascular–Kidney–Metabolic Health
Authors: Tain You-Lin , Hsu Chien-Ning
Published: September 2024

Background: The convergence of cardiovascular, kidney, and metabolic disorders at the pathophysiological level has led to the recognition of cardiovascular–kidney–metabolic (CKM) syndrome, which represents a significant global health challenge. Polyphenols, a group of phytochemicals, have demonstrated potential health-promoting effects. Methods: This review highlights the impact of maternal polyphenol supplementation on the CKM health of offspring. Results: Initially, we summarize the interconnections between polyphenols and each aspect of CKM syndrome. We then discuss in vivo studies that have investigated the use of polyphenols during pregnancy and breastfeeding, focusing on their role in preventing CKM syndrome in offspring. Additionally, we explore the common mechanisms underlying the protective effects of maternal polyphenol supplementation. Conclusions: Overall, this review underscores the potential of early-life polyphenol interventions in safeguarding against CKM syndrome in offspring. It emphasizes the importance of continued research to advance our understanding and facilitate the clinical translation of these interventions.
Design, Implementation, and Adaptation of a Tutoring Program for the Competency Development of New Nurses in a Hospital Emergency Department
Authors: Manero-Solanas Marta , Navamuel-Castillo Noelia , Garcés-Horna Silvia , López-Ibort Nieves , Gómez-Baca Carmen Angustias , Gascón-Catalán Ana
Published: September 2024

The healthcare environment faced by nurses is complex, with high workloads and situations of high comorbidity. The integration of nurses into the work environment is a cause for concern, and improvements are sought for their incorporation into the workforce. The benefits of mentoring programs are described not only for nurses but also for patients with safer practices and benefits for the institution due to the increased commitment of its professionals. A methodological article that illustrates the complete process to design and implement a tutoring program for new nurses in an emergency department is presented. The competency profile required for the figure of tutor was developed, including the steps followed for the development of the program and the structure and phases of which it is composed, as well as the validation of the evaluation instruments of the process. A strength was the participation of experts during the in-depth analysis of the competency profile, as well as in the adaptation of the evaluation items, which endorses the pertinence, relevance, usefulness, and clarity of the content of this program. The transparency in this methodology makes it possible to follow the steps for its reproduction and applicability in other hospitals.
Nursing Interventions in Primary Care for the Management of Maladaptive Grief: A Scoping Review
Authors: Rodríguez-Álvaro Martín , Brito-Brito Pedro Ruymán , García-Hernández Alfonso Miguel , Galdona-Luis Irayma , Rodríguez-Suárez Claudio Alberto
Published: September 2024

Grief is a natural and self-limited adaptation process to a new reality that emerges after a significant loss (whether real or perceived), with a broad variety of manifestations that exert an impact on a grieving person’s health. The study aim was to synthesize the evidence available about the interventions carried out by Primary Health Care nurses, by means of an individual approach to reduce maladaptive grief or maladaptive grief risk. A scoping review was conducted (November and December 2023) through searches in Medline, Cinahl, Web of Science, ProQuest and Scopus using MeSH terms combined with Booleans. Primary research of any design in adult people undergoing grief situations and receiving professional assistance by nurses in the primary, home and community care contexts published after 2009 in English, Spanish or Portuguese languages were included. Excluded publications were those conducted in in-hospital clinical settings and which did not correspond to research designs or the gray literature. The screening process was carried out by two reviewers using the appropriate JBI critical appraisal tools for each design and discrepancies were resolved by a third reviewer. A total of n = 10 studies were included (n = 4 qualitative, n = 2 RCTs, n = 1 quasi-experimental, n = 2 cross-sectional observational, and n = 2 mixed methods). The qualitative studies identified topics and subtopics of professionals’ and families’ experiences of grief. The observational studies analyzed symptoms and factors associated with the grieving process. Interventions consisted of cognitive–behavioral therapies delivered by psychological specialists who assessed the severity of grief in a range of cultural contexts using different instruments. The evidence retrieved from the studies that address the reduction in maladaptive grief or maladaptive grief risk is not conclusive. There is a need to increase both the number and the methodological quality of studies assessing the effectiveness of Nursing care in Primary Health Care for individuals experiencing maladaptive grief or maladaptive grief risk. Further research should focus on experimental studies, developing specific interventions conducted by nurses to address individual’s grief and prevent maladaptive grief.
Transcultural Perspectives in Nursing: Understanding the Role of Healers and the Evil Eye in Modern Healthcare
Authors: Curcio Felice , El Khabir Hafsa , Chelo Gianluca , Puggioni Sonia , Soddu Marica , Lucchetta Maria Raffaela , Avilés-González Cesar Iván
Published: September 2024

Background: The belief in the evil eye is defined as the power to cause harm through ‘negative energy’ obtained through a glance. The practice of “medicine of the evil eye or sa mexina de s’ogu” by the “feminas e ominis de mexina” (healers) is so deeply rooted in the Sardinian culture that it influences health practices. Transcultural nursing, conceptualised by Madeleine Leininger, emphasises the importance of providing health care that takes into account patients’ cultural beliefs, practices and values. This study aims to explore, from the perspective of Madeleine Leininger’s transcultural nursing theory, the perception of the “feminas e ominis de mexina” practising “sa mexina de s’ogu”, in order to promote and raise awareness among health professionals of the importance of patients’ beliefs and cultures. Methods: A qualitative phenomenological study was conducted. Data were collected using semi-structured face-to-face interviews. The interviews were transcribed, read thoroughly, and analysed. Results: Fourteen healers were interviewed. Six main themes were extracted: (1) figure of the healer in its social context; (2) dynamics and methodology related to rituals; (3) effects of the Evil Eye; (4) ritual demand; (5) effectiveness of the ritual; and (6) comparison between the ancient and modern world. Conclusions: These findings suggest that healers act as central pillars in the connection between traditional medicine and religious practices. In response to the results obtained, it is essential to train healthcare personnel in transcultural nursing in order to provide care that is respectful and in harmony with the individual’s beliefs, promoting their comfort and well-being, and their health outcomes.
Building Confidence, Diminishing Stress: A Clinical Incivility Management Initiative for Nursing Students
Authors: Kim Younglee , Kim Yeon Sook , Nwamu Henrietta , Lama Anne
Published: September 2024

Objective: The aim of this study was to evaluate the effectiveness of an interactive program designed to reduce nursing students’ perceived stress and improve self-efficacy and readiness to professionally address incivility during clinical practice. Background: Incivility in clinical settings adversely impacts learners, educators, institutions, and healthcare systems, undermining safety and the teaching–learning process. Despite its increasing global prevalence, effective interventions remain largely unexplored. Methods: Our mixed-methods study, conducted from March to April 2024, involved senior baccalaureate pre-licensure nursing students (N = 35) from a California State University. The three-week, one-hour-per-week, interactive clinical incivility management program was developed through an extensive literature review. Pre- and post-intervention differences were assessed using a 10 min self-administered online survey that included the Uncivil Behavior in Clinical Nursing Education (UBCNE; 12 items), Perceived Stress Scale (PSS; 10 items), General Self-Efficacy Scale (GSE; 10 items), and a sample characteristics questionnaire (11 items). A one-hour face-to-face focus group (n = 11) then provided qualitative data on personal experiences of clinical incivility. Quantitative data were analyzed using SPSS version 27, while qualitative data were analyzed using Colaizzi’s method. Results: Clinical incivility prevalence was 71.4% (n = 25 out of 35). No statistically significant differences were found in UBCNE, PSS, and GSE scores between pre- and post-intervention. However, professional responses to clinical incivility significantly improved after the intervention (t = −12.907, p < 0.001). Four themes emerged from the qualitative data: (a) uncivil behaviors or language from nurses, (b) emotional discouragement and low self-confidence, (c) resource and personnel shortages at clinical sites for education, and (d) the necessity for interventions to manage clinical incivility. Conclusions: Nursing schools and clinical agencies should collaborate to establish monitoring systems, enhance communication, and implement evidence-based policies and interactive interventions to prevent and manage clinical incivility experienced by nursing students from clinical sites.
Intravitreal Dexamethasone Implant in Anti-Vascular Endothelial Growth Factor Pretreated Diabetic Macular Edema—A Swiss Cohort Study
Authors: Turgut Ferhat , Somfai Gábor M. , Tappeiner Christoph , Hatz Katja , Mantel Irmela , Ambresin Aude , Donati Guy , Guignard Viviane , Nagyová Dana , Pfister Isabel B. , Schild Christine , Garweg Justus G.
Published: September 2024

Background/Objectives: Diabetic macular edema (DME) is a significant cause of visual impairment, often treated with anti-vascular endothelial growth factor (anti-VEGF) agents. However, some patients do not respond adequately to this treatment. This study aims to evaluate the contribution of the intravitreal dexamethasone (DEX) implant as a second-line treatment in DME patients with insufficient response to anti-VEGF therapy or with high treatment burden. Methods: This retrospective multicenter cohort study was conducted across seven clinical sites in Switzerland. The study included eyes with active DME that had been pretreated with anti-VEGF for at least six months before receiving DEX therapy. Data were extracted from electronic patient records, focusing on best-corrected visual acuity (BCVA), central subfield thickness (CST), and injection frequency. Results: A total of 95 eyes from 89 patients (38.8% females, mean age 65.6 ± 9.1 years, follow-up time 80.6 ± 38.5 [13.5–166.7] months) were analyzed. Prior to the first DEX implant, eyes had undergone an average of 16.0 ± 13.3 anti-VEGF injections over 32.5 ± 22.4 months. Post-DEX treatment, 22.1% of eyes received DEX monotherapy, 44.2% received a combination of DEX and anti-VEGF, 25.3% continued with anti-VEGF monotherapy, and 8.4% received no further treatment. The number of anti-VEGF injections decreased significantly from 6.4 ± 3.1 in the year before DEX to 1.6 ± 2.4 in the year after DEX (p < 0.001). BCVA remained stable (0.4 ± 0.3 logMAR at baseline, 0.4 ± 0.5 logMAR at 24 months, p = 0.2), while CST improved from 477.7 ± 141.0 to 320.4 ± 125.5 μm (p < 0.001), and the presence of retinal fluid decreased from 98.0% to 61.1% (p = 0.021). During follow-up, 26.3% of eyes required glaucoma medication, 4.2% underwent glaucoma surgery, and 1.1% needed cataract surgery. Conclusions: In real-world clinical settings, the addition of DEX to anti-VEGF therapy in DME patients significantly reduces treatment burden and retinal fluid while maintaining visual function. Treatment decisions should balance anatomical and functional outcomes, considering individual patient needs.
Comprehensive Analysis of Cetuximab Critical Quality Attributes: Impact of Handling on Antigen-Antibody Binding
Authors: Torres-García Alicia , Torrente-López Anabel , Hermosilla Jesús , Hernández Amparo , Salmerón-García Antonio , Cabeza José , Navas Natalia
Published: September 2024

Background/Objectives: Cetuximab, formulated in Erbitux® (5 mg/mL), is a therapeutic monoclonal antibody (mAb) widely used in several cancer treatments. Currently, there is insufficient knowledge about the behavior of cetuximab with regard to the risk associated with its routine handling or unintentional mishandling in hospitals. Forced degradation studies can simulate these conditions and provide insights into the biophysical and biochemical properties of mAbs. Methods: In this study, we conducted a deep physicochemical and functional characterization of the critical quality attributes of cetuximab in control samples and under controlled degraded conditions, including freeze–thaw cycles, heat, agitation, and light exposure. To achieve this purpose, we used a set of proper analytical techniques, including CD, IT-FS, DLS, SE/UHPLC-UV, UHPLC-MS/MS, and ELISA, to check functionality based on antigen–antibody binding. Results: The results revealed that light exposure was the stress stimuli with the greatest impact on the drug product, leading to the formation of non-natural oligomers, fragmentation, and oxidation of methionine residues. Additionally, cetuximab (Erbitux®, 5 mg/mL) showed a tendency to aggregate when submitted to 60 °C for 1 h. In terms of functionality, cetuximab (Erbitux®, 5 mg/mL) samples were found to be affected when subjected to freeze–thaw cycles, 60 °C (1 h), and when exposed to light (daylight with room temperature excursion and accelerated light exposure). Conclusions: Thus, we suggest that Erbitux® (5 mg/mL) should be shielded from these environmental conditions, as they compromise both the safety and efficacy of the drug product.
Deciphering Chemical Rules for Drug Penetration into Strongyloides
Authors: Marín Miguel , Sánchez-Montejo Javier , Ramos Sergio , Muro Antonio , López-Abán Julio , Peláez Rafael
Published: September 2024

Background: Strongyloidiasis, a parasitic infection, presents a significant public health challenge in tropical regions due to the limited repertoire of effective treatments. The screening of chemical libraries against the therapeutically relevant third-stage larvae (L3) of the model parasite Strongyloides venezuelensis yielded meager success rates. This situation is reminiscent of Gram-negative bacteria, where drug entry is a limiting factor. Methods: Here, we set out to determine whether similar barriers are in place and establish whether structural and property requirements exist for anti-strongyloides drug discovery. We focused on dyes as their uptake and effects on viability can be independently assessed in the multicellular parasite, thus providing a means to study the possibility of similar entry rules. We tested different dyes in in vitro assays on L3s. Results: We found that staining was necessary to reduce parasite viability, with some dyes achieving anti-strongyloides effects at concentrations similar to those of the reference drug, ivermectin (IV). Some dyes also showed activity against female adults at concentrations well below that of ivermectin. Unfortunately, the most potent dye, Methylene Blue, was unable to prevent the infection in a preliminary in vivo mouse model assay, presumably due to fast dye clearance. Structural analysis showed that positive charges facilitated the access of the compounds to the L3 tissue, thus providing a structural tool for the introduction of activity. For female adults, low globularity is additionally required. As a proof of concept, we added a positive charge to an inactive compound of one of our chemical libraries and re-determined the activity. Conclusions: These findings allow us to establish structural rules for parasite entry that could be of interest for future drug screening or drug development campaigns. These rules might also be applicable to other related parasites.
Integrating Hyperspectral Reflectance-Based Phenotyping and SSR Marker-Based Genotyping for Assessing the Salt Tolerance of Wheat Genotypes under Real Field Conditions
Authors: El-Hendawy Salah , Junaid Muhammad Bilawal , Al-Suhaibani Nasser , Al-Ashkar Ibrahim , Al-Doss Abdullah
Published: September 2024

Wheat breeding programs are currently focusing on using non-destructive and cost-effective hyperspectral sensing tools to expeditiously and accurately phenotype large collections of genotypes. This approach is expected to accelerate the development of the abiotic stress tolerance of genotypes in breeding programs. This study aimed to assess salt tolerance in wheat genotypes using non-destructive canopy spectral reflectance measurements as an alternative to direct laborious and time-consuming phenological selection criteria. Eight wheat genotypes and sixteen F8 RILs were tested under 150 mM NaCl in real field conditions for two years. Fourteen spectral reflectance indices (SRIs) were calculated from the spectral data, including vegetation SRIs and water SRIs. The effectiveness of these indices in assessing salt tolerance was compared with four morpho-physiological traits using genetic parameters, SSR markers, the Mantel test, hierarchical clustering heatmaps, stepwise multiple linear regression, and principal component analysis (PCA). The results showed significant differences (p ≤ 0.001) among RILs/cultivars for both traits and SRIs. The heritability, genetic gain, and genotypic and phenotypic coefficients of variability for most SRIs were comparable to those of measured traits. The SRIs effectively differentiated between salt-tolerant and sensitive genotypes and exhibited strong correlations with SSR markers (R2 = 0.56–0.89), similar to the measured traits and allelic data of 34 SSRs. A strong correlation (r = 0.27, p < 0.0001) was found between the similarity coefficients of SRIs and SSR data, which was higher than that between measured traits and SSR data (r = 0.20, p < 0.0003) based on the Mantel test. The PCA indicated that all vegetation SRIs and most water SRIs were grouped with measured traits in a positive direction and effectively identified the salt-tolerant RILs/cultivars. The PLSR models, which were based on all SRIs, accurately and robustly estimated the various morpho-physiological traits compared to using individual SRIs. The study suggests that various SRIs can be integrated with PLSR in wheat breeding programs as a cost-effective and non-destructive tool for phenotyping and screening large wheat populations for salt tolerance in a short time frame. This approach can replace the need for traditional morpho-physiological traits and accelerate the development of salt-tolerant wheat genotypes.
Preparation and Characterization of Graphene Oxide/Carbon Nanotube/Polyaniline Composite and Conductive and Anticorrosive Properties of Its Waterborne Epoxy Composite Coatings
Authors: Li Yufeng , Liu Shibo , Feng Feng , Li Yiming , Han Yahui , Tong Xinyang , Gao Xiaohui
Published: September 2024

The organic coating on the surface is common and the most effective method to prevent metal materials from corrosion. However, the corrosive medium can penetrate the metal surface via micropores, and electrons cannot transfer in the pure resin coatings. In this paper, a new type of anticorrosive and electrically conductive composite coating filled with graphene oxide/carbon nanotube/polyaniline (GO/CNT/PANI) nanocomposites was successfully prepared by in situ polymerization of aniline (AN) on the surface of GO and CNT and using waterborne epoxy resin (WEP) as film-forming material. The structure and morphology of the composite were characterized using a series of characterization methods. The composite coatings were comparatively examined through resistivity, potentiodynamic polarization curves, electrochemical impedance spectroscopy (EIS), and salt spray tests. The results show that the GO/CNT/PANI/WEP composite coating exhibits excellent corrosion resistance for metal substrates and good conductivity when the mass fraction of GO/CNT/PANI is 3.5%. It exhibits a lower corrosion current density of 4.53 × 10−8 A·cm−2 and a higher electrochemical impedance of 3.84 × 106 Ω·cm2, while only slight corrosion occurred after 480 h in the salt spray test. The resistivity of composite coating is as low as 2.3 × 104 Ω·cm. The composite coating possesses anticorrosive and electrically conductive properties based on the synergistic effect of nanofillers and expands the application scope in grounding grids and oil storage tank protection fields.
The Influence of Hemp Fibers (Cannabis sativa L.) on the Mechanical Properties of Fiber–Gypsum Boards Reinforcing the Gypsum Matrix
Authors: Trociński Adrian , Wieruszewski Marek , Bartkowiak Monika , Dziurka Dorota , Mirski Radosław
Published: September 2024

The modern construction industry is looking for new ecological materials (available, cheap, recyclable) that can successfully replace materials that are not environmentally friendly. Fibers of natural origin are materials that can improve the properties of gypsum composites. This is an important issue because synthetic fibers (hardly biodegradable—glass or polypropylene fibers) are commonly used to reinforce gypsum boards. Increasing the state of knowledge regarding the possibility of replacing synthetic fibers with natural fibers is another step towards creating more environmentally friendly building materials and determining their characteristics. This paper investigates the possibility of manufacturing fiber–gypsum composites based on natural gypsum (building gypsum) and hemp (Cannabis sativa L.) fibers grown in Poland. The effect of introducing hemp fibers of different lengths and with varying proportions of mass (mass of gypsum to mass of fibers) into the gypsum matrix was investigated. The experimental data obtained indicate that adding hemp fibers to the gypsum matrix increases the static bending strength of the composites manufactured. The highest mechanical strength, at 4.19 N/mm2, was observed in fiber–gypsum composites with 4% hemp fiber content at 50 mm in length. A similar trend of increased strength was observed in longitudinal tension. Again, the composite variant with 4% fiber content within the gypsum matrix had the highest mechanical strength. Manufacturing fibers–gypsum composites with more than 4% hemp fiber content negatively affected the composites’ strength. Mixing long (50 mm) hemp fibers with the gypsum matrix is technologically problematic, but tests have shown a positive effect on the mechanical properties of the refined composites. The article indicates the length and quantity limitations of hemp fibers on the basis of which fiber–gypsum composites were produced.