bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone marrow stem cell applied in the canine veterinary clinics
Authors: Gomes Ingrid S. , Oliveira Vanessa C. de , Pinheiro Alessandra O. , C.S.Roballo Kelly , Araujo Giuliano S.M. de , Veronezi Jessica C. , Martins Daniele S. , Ambrósio Carlos Eduardo
Published: January 2018

ABSTRACT: Cell therapy represents an old therapeutic practice initiated with the transfusion of whole blood in different clinical situations. There is now a breakthrough in the study of multipotent stem cell therapy because of its functionality in regeneration of tissues, which promotes attention of the scientific community. Bone marrow is one of the main sources of multipotent stem cells, composed by hematopoietic stem cells responsible for the renewal of the cellular components of the blood, and mesenchymal stem cells that aid in the regeneration of tissues. These cells have a strong potential for the treatment of several diseases, due their main characteristics such as high plasticity, capacity for self-renewal and immunomodulation. Although, there are many studies that show good results with the use of cell therapy as a form of treatment for several diseases, some studies still show inconclusive or unsatisfactory results. Therefore, the objective of this study was to review the application of bone marrow stem cells in the canine model since improvements on the knowledge of the technique are necessary to enable its applicability with safety and efficacy.
Pesquisa de Mycoplasma em aves da família Psittacidae mantidas em diferentes cativeiros no Brasil Central
Authors: Carvalho Andréa M. , Andrade Maria A. , Linhares Guido F.C. , Jaime Valéria S.
Published: January 2018

RESUMO: O presente estudo teve como objetivo investigar a presença de Mycoplasma gallisepticum e M. synoviae em diferentes espécies de psitacídeos cativos no Brasil Central. Um total de 300 amostras foram coletadas e corresponderam a 41 espécies de psitacídeos da fauna brasileira, provenientes do CETAS, criadouro comercial e criadouro conservacionista. Quatorze espécies apresentaram amostras positivas para M. gallisepticum destacando a maracanã-verdadeira (Primolius maracana) (01/02, 50%), a arara-canindé (Ara ararauna) (15/48, 33,3%) e a jandaia-verdadeira (Aratinga jandaia) (03/10, 30%). Amostras do CETAS obtiveram total de 21,62% (16/74) de amostras positivas, do criadouro comercial 15,7% (19/121) e do criadouro conservacionista 6,66% (7/105). Apenas três espécies foram positivas para M. synoviae sendo essas, a maracanã-pequena (Primolius maracana) (1/10 - 10%), arara-macao (Ara macao) (1/12, 8,3%) e arara-canindé (Ara ararauna) (2/48, 4,1%). O CETAS obteve 2,7% (2/74) de amostras positivas totais, enquanto o criadouro conservacionista obteve total de 1,9% (2/105) de amostras. Não ocorreram amostras positivas para M. synoviae no criadouro comercial. Os resultados mostraram um considerável número de amostras positivas para M. gallisepticum em espécies da família Psittacidae, indicando que estes animais podem ser uma fonte de infecção silenciosa para outras aves, uma vez que não apresentaram sintomatologia clínica.
Aspectos ultrassonográficos, anatômicos e histológicos normais da articulação metacarpofalangeana equina
Authors: Bastiani Grasiela De , Corte Flavio De La , Kommers Glaucia D. , Brass Karin E. , Pereira Roberta , Cantarelli Camila , Silva Taiara M. da
Published: January 2018

RESUMO: O objetivo deste estudo foi descrever e caracterizar as estruturas que compõem a articulação metacarpofalangena equina por meio de análise ultrassonográfica, anatômica e histológica. Membros torácicos equinos (=70), obtidos em instalações frigoríficas, foram submetidos a exame ultrassonográfico post mortem. Destes, 30 membros apresentaram imagens ultrassonográficas consideradas sem alterações. Posteriormente foi realizada a dissecação dos mesmos e o estudo anátomo-histológico. Critérios como tamanho, forma, arquitetura e ecogenicidade foram observados a fim de caracterizar as imagens ultrassonográficas, anatômicas e histológicas normais das estruturas ligamentares, tendíneas, capsulares e cartilaginosas da articulação metacarpofalangeana equina.
Portal Vein Dopplerflowmetry in healthy sheep according to age
Authors: Belotta Alexandra F. , Santarosa Bianca P. , Ferreira Danilo O.L. , Carvalho Sílvia M.F. , Gonçalves Roberto C. , Padovani Carlos R. , Mamprim Maria J.
Published: January 2018

ABSTRACT: Pulsed Doppler ultrasound was used to evaluate portal blood flow, portal velocity and portal congestion index in 24 healthy sheep divided into groups (lambs, yearlings and ewes), according to age. Measurements were performed at the 11th right intercostal space using ideal insonation angle and uniform insonation method. Mean values obtained in each group were compared with one-way ANOVA, followed by Tukey post-hoc test. Portal velocity and portal blood flow were statistically similar between the groups (P>0.05). Mean portal velocity were 17.75; 17.13 and 16.75; while mean portal blood flow were 26.65; 31.04 and 24.32 for lambs, yearlings and ewes, respectively. Portal congestion index was statistically distinct between the groups and values for lambs, yearlings and ewes were 0.009; 0.058 and 0.09, respectively (P<0.01). Statistical differences were observed in portal vein diameter, portal vein area and portal congestion index between the groups, presumably due to influence of weight and not to age.
Counseling Adults With Food Allergies After an Anaphylactic Reaction: An Application of Emotion-Focused Therapy
Authors: Taylor Jessica Z. , Lewis Chrystal L.
Published: January 2018

Little information is known about how counselors may work with adult clients regarding psychosocial sequelae of food allergies. The current article aims to provide counselors with a deeper understanding of life-threatening food allergies, ways in which adults may attempt to manage food allergies in adulthood, and emotional reactions that may occur after experiencing anaphylaxis. This article discusses ways that counselors can utilize emotion-focused therapy (EFT) interventions to help adult food-allergic clients process emotional reactions after experiencing anaphylaxis due to an ingested food allergen. Both in-session and at-home EFT strategies are discussed. EFT for trauma is discussed as a potential direction for future counseling research. Medical family therapy is discussed as a potential direction for counseling practice so that counselors may have a framework for working with other health-care professionals to help address food-allergic adult clients' psychosocial needs.
Impact of Depressive Symptoms and Alcohol Use on Disordered Eating and Suicidality: A Moderated Mediation Study
Authors: Mugoya George C. T. , Hooper Lisa M. , Chapple Brynn , Cumi Kish
Published: January 2018

While previous studies have tested the mediating or moderating effects of select factors on disordered eating pathologies, no empirical studies have examined a moderated mediation model. Thus, filling a gap in the literature base, the current study examined a moderated mediation model to test the associations among disordered eating, depressive symptoms, alcohol use, and suicidality. The current study sample included 1,598 students (mean age 21.3 years; 80.9% female) across major universities in the United States. Results showed that disordered eating was significantly associated with suicidality, and the association was mediated by depressive symptoms. Further, the indirect effect of disordered eating via depressive symptoms varied in magnitude as a function of alcohol use. Findings suggest that clinical mental health counselors and other providers working with emerging adults should be vigilant in recognizing behaviors and thoughts associated with disordered eating and related signs and symptoms, including depressive symptoms and alcohol use.
Practitioner Perspectives on Animal-Assisted Counseling
Authors: Hartwig Elizabeth Kjellstrand , Smelser Quinn Koelfgen
Published: January 2018

The field of animal-assisted counseling (AAC) is burgeoning. However, there is a paucity of research on the perspectives of mental health practitioners regarding its practice and the experience and training needed to effectively utilize AAC with clients. The purpose of this study was to explore how practitioners perceive AAC and its role in clinical settings. Perceptions of 300 mental health practitioners were assessed using a researcher-developed survey instrument. Findings indicated that a majority of practitioners (91.7%) view AAC as a legitimate counseling modality. Practitioners identified client age ranges and the top five clinical issues that would benefit from AAC. While only 12.0% of respondents had received training in AAC, 57.0% of respondents reported interest in receiving AAC training. Respondents identified types of AAC education, training, and supervision that would be sufficient for clinicians to utilize AAC. The findings from this study contribute to the emerging literature on AAC.
Surgical treatment of right-sized visceroptosis
Authors: Bokovoj Sergej P
Published: January 2018

This article is devoted to the surgical treatment of right-sided visceroptosis. The original methods of nephropexy, colopexy and hepatopexy are described in details. The indications and peculiarities of the preparation for these operations are given as well as the peculiarities of postoperative management of such patients. Long-term results of surgical treatment of right-sided visceroptosis in 103 patients are presented in the article. A good result was found in 93 (90.3%) patients and satisfactory result in 10 (9.7%) patients. (For citation: Bokovoj SP. Surgical treatment of right-sized visceroptosis. Urologicheskie vedomosti. 2017;7(4):30-38. doi: 10.17816/uroved7430-38).
The state of prostate hemodynamics in patients with myophascial pain syndrome
Authors: Krupin Valentin N , Krupin Alexey V , Belova Anna N , Nashivochnikova Natalya A
Published: January 2018

The aim of this study was to evaluate the state of blood flow in prostate in 59 men with chronic pelvic pain due to myofascial syndrome in the absence of clinical manifestations of chronic prostatitis and its dynamics against the background of the treatment. The results of the study revealed a reliable relationship between the severity of blood flow disorders in the prostate and the intensity of pain symptoms caused by myofascial syndrome. It was concluded that the hemodynamic disorders of the prostate caused by myofascial syndrome are important in the possible formation of clinical symptoms of chronic pelvic pain in men. (For citation: Krupin VN, Krupin AV, Belova AN, Nashivochnikova NA. The state of prostate hemodynamics in patients with myophascial pain syndrome. Urologicheskie vedomosti. 2017;7(4):39-43. doi: 10.17816/uroved7439-43).
Alice Springs Telecommunications Facilities
Authors: Moorhead Simon
Published: January 2018

Two papers from the Journal in 1939 and 1990 respectively contrasting the telecommunication facilities and lifestyles at Alice Springs.
Abdominal wall closure in the presence of sepsis (acute abdomen): role of negative suction
Authors: P. B. Thrishuli , E. Pavan Kumar
Published: January 2018

Background: To compare and find out the best method of abdominal wall closure in cases peritonitis between subcutaneous negative suction drainage tube and conventional primary skin and subcutaneous closure.Methods: From September 2015 to September 2017, 100 patients who presented at the emergency department with acute abdominal pain and operated for the same, with features s/o peritonitis were enrolled into the study. 50 of them were managed with subcutaneous negative suction drainage tube during abdominal wall closure (Group A). 50 other patients underwent conventional method of abdominal wall closure (Group B). On table pus c/s was sent for all 100 cases. The surgical wound was observed for signs of infection. Any seropurulent collection from the drain or any discharge from the wound was sent for c/s and the results of which were compared with the results of on table pus c/s. If wound dehiscence was noted, secondary suturing was done after the wound healed. The duration of suction drain placement and stay in the hospital were noted in all cases. The results were analyzed with Chi-square test and Student t test (unpaired) and p values were calculated. A p value of less than 0.05 was considered significant.Results: The incidence of SSI was significantly less in Group A (20%) than in Group B (64%). Similarly, wound dehiscence occurred in 30% of SSI cases in Group A as against 87.1% of SSI cases in Group B, the difference of which was statistically significant. The mean duration of hospital stay was significantly less when subcutaneous suction drain was placed (8 days).Conclusions: Subcutaneous suction drainage tube is an effective method of abdominal wall closure in cases of peritonitis when compared to conventional primary skin closure as it significantly reduces the incidence of SSI, wound dehiscence, wound secondary suturing and duration of hospital stay.
Web design for user experience: Virgin America web site case study
Authors: Gocmen Pelin Ozturk
Published: January 2018

Web usability is the ease of use of a website. Some goals of usability are the presentation of information and choices in a clear and concise way, a lack of ambiguity and the placement of important items in appropriate areas. On the other hand, user experience is something more than usability. It includes each and every experience that the users have while using the service. And of course, usability rules affect the user experience. In this study, understanding the principles of user-centered design and how it improves user experience is the main purpose. For this aim, https://www.virginamerica.com, which is the web site that gained the two thousand sixteen Best User Experince award from The Webby Awards, has been studied as a case study. 

 

Keywords: web design, user experience, Virgin America.
HARGA DIRI DAN INTENSI MEMBELI JERSEY SEPAK BOLA TIRUAN PADA REMAJA
Authors: W. SUPARNO EKO , GUMELAR GUMGUM , WIBISONO ARIF
Published: January 2018

This study aims to determine the effect of self-esteem to buying intention a fake football jersey of adolescents in Bogor city. The subject of this study is amounted to 70 respondents. The sample character of this study is adolescents aged from 15-18 years old, and the gender is man or women and football fans. The type of this study is quantitative study and the technique that researched use is non-probability purposive sampling.â€¨The researched used questionnaire technique to collect all data , the questionnaire that researched used is instrument of self-esteem, which is adapted from the Coopersmith Self-Esteem Inventory-School form and instrument of intention of buying Shukla with add three items of another buying intention, static analyst that used Based on research result, showing that there is significant influence between self-esteem against buying intention , at the R square value, the result of this study researched earned a value amounted of 0,150(15%),that means is self-esteem give influence amounted 15% against buying intention.
EFIKASI DIRI DAN KEMAMPUAN LITERASI INFORMASI PADA GURU SEKOLAH MENENGAH ATAS
Authors: DWIUTAMI LUSSY , WARDI TANTRI DWINANTIKA
Published: January 2018

This study aims to determine the relationship between teachersâ€™ efficacy with information literacy skill on high-school teacher. This reaserch used qualitative approach with correlational research method. Population in this study was high-shcool teachers whom teached with curriculum 2013 in DKI Jakarta. Samples that used was 100 teachers using quota sampling technique. Measurement of information literacy used adaptation instrument made by Tisa Lina Putri (2013) based on The Big6 Model with instrument reliability was 0.94. Teachers efficacy was measured by Teacher Sense of Efficacy Scale from Tschannen-Moran and Woolfolk Hoy (2001) with reliability of 0.70. Based on the results of data analysis, obtained the results there is a relationship between teacher efficacy with information literacy on the teacher. The result correlation value is 0.369 with a significance of 0.000 at a significance level of 5%. Thus it can be concluded that there is a positive relationship between the teachers efficacy with information literacy.
Telemedicine Use Among Caregivers of Cancer Patients: Systematic Review (Preprint)
Authors: Marzorati Chiara , Renzi Chiara , Russell-Edu Samuel William , Pravettoni Gabriella
Published: January 2018

BACKGROUND

The number of published studies and systematic reviews examining different telehealth interventions targeting patients and their effects on patients’ well-being and quality of life have grown in recent decades. However, the use of telemedicine tools aimed at the family members and caregivers of adult cancer patients is less defined.

OBJECTIVE

We aimed to conduct a systematic review to provide a more complete picture regarding telemedicine tools for informal caregivers (usually family members or close friends) implemented in all phases of cancer care. More specifically, the review aimed to better describe the study samples’ characteristics, to analyze measured outcomes and the specific questionnaires used to assess them, and to describe in depth the implemented interventions and their formats. Finally, we examined the role of telehealth, and usability and feasibility trends in supporting patients’ caregivers.

METHODS

We systematically searched the literature in the following databases: Web of Science, Cochrane Library, PubMed, Scopus, CINAHL, MEDLINE, EMBASE, Google Scholar, and PsycINFO. Inclusion criteria were being written in English, published in peer-reviewed journals, describing a telehealth-implemented intervention, and focusing on caregivers of adult cancer patients at any stage of the disease. We selected studies published up to November 2017. We critically appraised included articles using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and graded the quality of evidence by outcome using the Centre for Evidence-Based Medicine framework.

RESULTS

We included 24 studies in the final selection. In 21 of the 24 studies, the patient-caregiver dyad was analyzed, and the study population dealt with different types of cancer at different stages. Included studies considered the caregiver’s condition from both an individual and a relational point of view. Along with psychosocial variables, some studies monitored engagement and user satisfaction regarding Web-based platforms or telehealth interventions. All studies reported significant improvements in some of the investigated areas, but they often showed small effect sizes. Two types of telehealth intervention formats were used: Web-based platforms and telephone calls. Some of the included studies referred to the same project, but on study samples with different cancer diagnoses or with new versions of previously developed interventions.

CONCLUSIONS

Reported outcomes seem to suggest that we are in an exploratory phase. More detailed and targeted research hypotheses are still needed. Clarifying caregivers’ needs related to telehealth tools and better defining outcome measures may yield more significant results.
The sky�s the limit: A longitudinal study on how Facebook improves the psychological well-being of individuals experiencing homelessness (Preprint)
Authors: Calvo Fran , Carbonell Xavier
Published: January 2018

BACKGROUND

Background: Online social networks are a powerful communicative element whose use is increasingly widespread. Persons in a extreme social exclusion like persons experiencing homelessness (IEH) can be beneficiated of the positive elements of communication and relationship associated with social network sites.

OBJECTIVE

Objective: This study suggests the comparison of a Facebook training course and an office software course and their effect on psychological well being in a group of IEH.

METHODS

Methods: Experimental and longitudinal study was designed. A sample of IEH were assigned to the Facebook group or the office software group randomly and their social skills, Self-Esteem, Self-Efficacy and Life Satisfaction were measured on four occasions: pre test, at the end of the training course, one month later and three months later. A mixed ANOVA of repeated measures (2x4) was performed.

RESULTS

Results: A total of 92 IEH participated in the study. The number of cases in which the 4 observations were completed was 71 (35 in the intervention group and 36 in the control group). The mixed ANOVA of repeated-measures and the multiple regression analysis indicated a significant increase of the four analyzed parameters, more significant in social skills and Self-Esteem. The critical level associated to the interaction Time*Program were significant in all variables and levels. Therefore, the scores in the 4 analyzed constructs were not equal according to the program carried out throughout the work. The effect size associated to the interaction Time*Program in the scores of social skills was large (Eta2 = .32), in the self-esteem and selt-efficacy scores it was medium, (Eta2 = .13) and in satisfaction with life scores it was small (Eta2 = .09). The results of the adjustment of the different models of multiple linear regression indicate that the number of hours devoted weekly to the use of Facebook was a predictor of the increase in the scores of social skills (B = 3.43, r2 = .405) and self-esteem (B = .382). Age (B = .175) and self-efficacy (B = .09) were also variables which with independence and in equal conditions predicted the self-esteem (r2 = .29). Finally, self-esteem (B = .69) was also a predictor variable of the increase of satisfaction with life (r2 = .195).

CONCLUSIONS

Conclusion: These findings suggest that Facebook could be a key element in homeless psychological wellbeing and socialization.
The Use of Wearable Activity Trackers Among Older Adults: Focus Group Study of Tracker Perceptions, Motivators, and Barriers in the Maintenance Stage of Behavior Change (Preprint)
Authors: Kononova Anastasia , Li Lin , Kamp Kendra , Bowen Marie , Rikard R.V. , Cotten Shelia , Peng Wei
Published: January 2018

BACKGROUND

Wearable activity trackers offer the opportunity to increase physical activity through continuous monitoring. Viewing tracker use as a beneficial health behavior, we explored the factors that facilitate and hinder long-term activity tracker use, applying the transtheoretical model of behavior change with the focus on the maintenance stage and relapse.

OBJECTIVE

The aim of this study was to investigate older adults’ perceptions and uses of activity trackers at different points of use: from nonuse and short-term use to long-term use and abandoned use to determine the factors to maintain tracker use and prevent users from discontinuing tracker usage.

METHODS

Data for the research come from 10 focus groups. Of them, 4 focus groups included participants who had never used activity trackers (n=17). These focus groups included an activity tracker trial. The other 6 focus groups (without the activity tracker trial) were conducted with short-term (n=9), long-term (n=11), and former tracker users (n=11; 2 focus groups per user type).

RESULTS

The results revealed that older adults in different tracker use stages liked and wished for different tracker features, with long-term users (users in the maintenance stage) being the most diverse and sophisticated users of the technology. Long-term users had developed a habit of tracker use whereas other participants made an effort to employ various encouragement strategies to ensure behavior maintenance. Social support through collaboration was the primary motivator for long-term users to maintain activity tracker use. Short-term and former users focused on competition, and nonusers engaged in vicarious tracker use experiences. Former users, or those who relapsed by abandoning their trackers, indicated that activity tracker use was fueled by curiosity in quantifying daily physical activity rather than the desire to increase physical activity. Long-term users saw a greater range of pros in activity tracker use whereas others focused on the cons of this behavior.

CONCLUSIONS

The results suggest that activity trackers may be an effective technology to encourage physical activity among older adults, especially those who have never tried it. However, initial positive response to tracker use does not guarantee tracker use maintenance. Maintenance depends on recognizing the long-term benefits of tracker use, social support, and internal motivation. Nonadoption and relapse may occur because of technology’s limitations and gaining awareness of one’s physical activity without changing the physical activity level itself.
Analisis Perbandingan Keuntungan dan Risiko Usaha Perikanan Rakyat Sistem Monokultur dan Polikultur di Kabupaten Pangkep
Authors: Husain Tsalis Kurniawan , Mulyo Jangkung Handoyo , Jamhari Jamhari
Published: January 2018

The purpose of this research is to analyze and compare the cost, profit, and risk of monoculture and polyculture fisheries system in Pangkep Regency. The sample collection uses the snowball sampling method. There are 80 fish farmers who were interviewed in this research. The cost and income is analyzed by income analysis, while to measure the level of business risk, Coefficients Variation (CV) analysis is used. To test the hypothesis, analysis of z distribution test is used. The research results show that the fishing cost and income of polyculture system is larger than monoculture system, where the cost of each is Rp 14.722.597 and Rp 13.191.880 respectively, while their profit is Rp 10.285.066 and Rp 6.710.486 each. Polyculture system has cost risk, revenue risk and profit risk is lower than monoculture system with large value of Coefficients Variation (CV) each by 0,11; 0,29 and 0,56 for polyculture system and 0.12; 0,37 and 0,88 for monoculture system. The results of the hypothesis showed that there is difference in cost of, revenue, and profit between poliyculture and monoculture system while there is no significance difference for cost risk, revenue risk and profit risk.
Pemaknaan Pelaku Usaha Dalam Pengembangan Pangan Lokal Di Kabupaten Lombok Barat
Authors: Jannah Eka Nur , Wastutiningsih Sri Peni , Partini Partini
Published: January 2018

This study has the purpose to explain the meaning of business actors in the development of local food in West Lombok and explain the meaning of busines actors towards the involvement of primary and secondary stakeholders in the development of local food in West Lombok. This study used a qualitative method with phenomenological approach. Selection of a method purposive. Selection of informants using methods purposive ie businesses which process local food derived from terrestrial plant. The results showed that the meaning of efforts in the development of local food is positive as it can be an additional source of income for families, create jobs and expand social networks, but variations in the types of processed and flavor is still less diverse and less than optimal marketing. Primary and secondary stakeholders involved in the development of local food by providing assistance and motivation to constantly improve the quality and quantity of processed food products locally as well as marketing. But some stakeholders are not optimal involvement in the development of local food. The lack of optimization due to a lack of common ground between the businessmen and the stakeholders as well as between the stakeholders. Looking forward there are organizations that can coordinate and stakeholder businesses so that they can equate the views related to the development of local food and stakeholders can engage with the optimal local food  development becomes more leverage.
Relative Efficiency of Brown Sugar Agroindustry in Kokap District, Kulon Progo Regency, D.I. Yogyakarta
Authors: Wijayanti Dian Eswin , Hartono Slamet , Darwanto Dwidjono Hadi
Published: January 2018

Agriculture industry is the activity using agriculture product as raw material by further process become the result product and is conducted by packaging, saving to the distributor toward consumer. Coconut (Cocos Nucifera) is one of agriculture commodity that has good potential market in Kulon Progo. Besides sold as a fresh product, coconut tree also produced nira (liquid from palm tree) that is quite potential if it is further process become brown sugar (brown sugar) to increase economic value from the characteristic of agriculture commodity. Thus, agriculture industry in that region could overcome the weaknesses of agriculture product through efficient production. The efficiency of production is obtained if input and output is used optimally so that it is able to give the advantage for agent of agriculture industry. This research is aimed to (1) analyze production efficiency of brown sugar agriculture industry, (2) to analyze external factors which affecting production efficiency of brown sugar. Basic research method which is quantitative approach supported by qualitative approach. The research is conducted in sub-district of Kokap, Kulon Progo, Yogyakarta with 100 respondents that is randomly chosen. Data of production efficiency on agriculture industry of brown sugar is obtained through Data Envelopment Analysis (DEA) by classifying into 30 Decision Making Unit (DMU). The classification is conducted based on the amount of raw material which used, while linier regression is using for Ordinary Least Square (OLS) that is used to analyze external factors which affect production efficiency on  agriculture industry of brown sugar. The result of research shows that the production on agriculture industry of brown sugar is more inefficient that is 28 DMU (93,33%) and the efficient production is only 2 DMU (6,67%). The external factor affected toward efficiency of agriculture industry production of brown sugar are the age of farmer, the experience of flow quickly, and the amount of coconut tree for nira.
CHRONIC HEART FAILURE CAUSES OSTEOPATHY OR IS OSTEOPATHY A FACTOR IN DEVELOPMENT OF CHRONIC HEART FAILURE?
Authors: Marushchak Mariya , Krynytska Inna , Mikolenko Anna , Andreychyn Yurii , Bodnar Yaroslav
Published: January 2018

Objective: As their proportion rises in the aging population, cardiovascular disease and osteoporosis increasingly become significant health problems of the developed world, leading to reduced lifespan and substantial financial burdens, not the least because of complications and comorbidities associated with each disorder. This study investigates bone mineralization in patients with coronary heart disease (CHD) complicated by Stage I chronic heart failure (CHF).Methods: The study group consisted of 41 patients of both sexes with CHF Stage I against the background of CHD that with no severe comorbidities that could have potentially caused changes in bone tissue. Bone mineral density was measured using dual-energy X-ray densitometry of lumbar region of spine and proximal right femur.Results: Structural and functional changes in the bone of the lumbar spine were found in 75.9% of the patients with Stage I CHF caused by CHD. Osteopenia was diagnosed in 64.4% of the patients, while osteosclerotic bone changes were less frequent and found in 11.5% of the patients. 75.8% of the patients had structural and functional changes in the proximal segment of the right femur bone. In men with Stage I CHF against the background of CHD osteopenia was more often diagnosed in the proximal segment of the right femur, while in women it was found in almost equal proportion in the spine and hip.Conclusions: In both sexes with I Stage CHF against the background of CHD were diagnosed changes in bone mineralization, with osteopenia being the prevailing diagnosis.
FORMULATION AND PHYSICAL CHARACTERISTICS OF DETAM II SOYBEAN (GLYCINE MAX (L.) MERR) TABLET WITH VARIOUS CONCENTRATION OF SILICON DIOXIDE AND MAGNESIUM STEARATE
Authors: Yulia Rika , Pradana Aditya Trias , Sie Sylvia Silvanus , Suri Fitria Atika
Published: January 2018

Objective: This research was conducted to obtain several formulation and evaluate the physical characteristics of the soybean Glycine max (L.) Merr Detam II variety tablets.Methods: Detam II varieties of soybean (G. max (L.) Merr.) were cleaned and grinded into 30 mesh-sized powder. Weighed soybean powder and internal phase of excipients (based on the formula) mixed by a Y-cone mixer until homogeneous, and then continue with dry granulation process. Granules formed, then sieved into 16 mesh size, and then, the characteristics examined. Dried granules then mixed with magnesium stearate and silicon dioxide using a drum mixer and compressed into tablets. Physical characteristics of tablets measured at 0, 4, 7, 14, 21, and 28 days.Results: Evaluation was done for particle size distribution, moisture content (MC), flow properties, weight uniformity, friability, hardness, and disintegration time. Dry granulation was the best method to improve the characteristics of soybean powder with poor compressibility, poor flowability, and hygroscopic. Flow properties of the granules became better for Formula II and III by adding the concentration of silicon dioxide. The formulas also showed the good uniformity of weight, size, MC, friability, and disintegration time. Reducing the lubricant until 0, 5% of the formula made differences in friability, hardness, and disintegration time better than another formula.Conclusion: The result of this research indicates that differences in silicon dioxide and magnesium stearate composition of the formula can affect the physical characteristics of soybean (G. max (L.) Merr.) tablets.
THE ROLE OF ACALYPHA INDICA LINN. EXTRACT ON HEART RATES WITH MYASTHENIA GRAVIS RAT MODEL
Authors: Krisnamurti Desak Gede Budi , Hakim Rani Wardani , Antarianto Radiana Dhewayani , Farida Siti , Purwaningsih Erni Hernawati , Purba Jan Sudir
Published: January 2018

Objective: Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle. Acetylcholine is also used as a neurotransmitter in the autonomic nervous system. Striated cardiac muscle can be a target for immune attack manifesting as heart failure, arrhythmia, and sudden death. Involvement of the heart rate (HR) has been claimed and reported, but a causal connection between MG and altered cardiac function has not been found.Methods: For this study of experimental autoimmune MG (EAMG) is used rocuronium, prostigmine, and Acalypha indica (AI) Linn. compared with HR.Results: From the results, the study found that sympathetic activity of HR variability in EAMG injected with rocuronium 10 mg/kg body weight (BW) in 10 min significantly found increasing in measures of short-term variations in HR variability, indicating parasympathetic impairment.Conclusion: We conclude that in MG, cholinergic transmission is affected more diffusely than previously thought. Furthermore, AI was given orally 30 mg/kg BW has an effect similar to the injecting of prostigmine 10 mg/kg BW that can reduce HR. Driven by the fact that the pharmacological treatment of MG is unsatisfied, it needs the therapeutic development for MG using herbal ingredients of AI. This means that the AI compositions containing anti-MG whose composition should be investigated for the next research.
PHARMACOPHORE SCREENING AND MOLECULAR DOCKING OF PHYTOCONSTITUENTS IN POLYGONUM SAGITTATUM FOR CYCLOOXYGENASE-2 INHIBITORS DISCOVERY.
Authors: Megantara Sandra , Mw Agung Yodha , I Sahidin , Diantini Ajeng , Levita Jutti
Published: January 2018

Objective: The objective of this study is to discover cyclooxygenase (COX-2) inhibitors from Polygonum sagittatum (Polygonaceae), by screening the pharmacophores based on the interaction of mefenamic acid with COX-2, followed by molecular docking with COX-2.Methods: The protein crystal structure of human COX-2 in complex with mefenamic acid (PDB code: 5IKR) was selected, its ligand-protein interaction was studied by employing LigandScout to obtain the pharmacophore features. The features were validated against PGH2 database provided at http://dude.docking.org/targets/pgh2, and the result was used to screen the pharmacophores of the phytoconstituents isolated from P. sagittatum. Furthermore, a molecular docking of the phytoconstituents into COX-2 binding pocket was performed. The compounds were generated using MarvinSketch, and the energy was optimized by employing LigandScout MMFF94. Celecoxib and mefenamic acid, selective COX-2 inhibitors, were used as the standard drugs.Results: The pharmacophore features obtained were aromatic ring (hydrophobicity) and two hydrogen bond acceptors, which are proved valid against PGH2 training set (GH score = 0.78; AUC100% receiver operating characteristic curve = 0.97). There are four phytoconstituents (quercetin, protocatechuic acid, vanicoside A, and vanicoside B) that fit the features, and therefore, are predicted to be active in inhibiting COX-2. The docking reveals that three phytoconstituents (methyl-4-hydroxycinnamate, quercetin, and methyl gallate) interact with Tyr385, an important amino acid residue in COX-2 binding pocket. Quercetin is the best in inhibiting the enzyme (docking score −8.60 kcal/mol; inhibition constant 0.5 μM), compared to mefenamic acid (docking score −8.90 kcal/mol; inhibition constant 0.3 μM) and celecoxib (docking score −10.00 kcal/mol; inhibition constant 0.05 μM).Conclusions: Phytoconstituents in P. sagittatum fit the pharmacophore features generated from mefenamic acid and COX-2 complex; therefore, they might be potential in inhibiting COX-2 enzyme. Their binding modes are more similar to that of mefenamic acid than of celecoxib. Of those, quercetin is the best in inhibiting the enzyme. Its inhibitory activity is equal to mefenamic acid but is weaker than celecoxib.
STUDY OF SERUM FERRITIN IN SMOKERS
Authors: Shivasekar Meera , Vm Vinodhini , Y Rupesh Kumar
Published: January 2018

Objective: Cigarette smoking is a major global public health problem and increases in the prevalence of tobacco smoking is the cause premature death worldwide. Serum ferritin an intracellular protein that can store and release iron is considered to be one of the important clinical biomarkers to evaluate iron status. This study explores the effect of cigarette smoking on serum ferritin level.Methods: The study was carried out in 100 cigarette smokers and 100 nonsmokers.Results: Subjects with smoking habits showed a significant increase in the serum ferritin levels compared to nonsmokers. Serum iron level, as well as total iron-binding capacity, showed significant increase compared with nonsmokers. Serum ferritin is found to correlate with serum iron.Conclusion: This study supports the fact that cigarette smoking has adverse effect on serum ferritin and other hematologic parameters, and serum ferritin is one of the most reliable indicators of iron status.
ANTIOXIDANT ACTIVITY OF RED DRAGON FRUIT PEEL (HYLOCEREUS POLYRHIZUS (F.A.C. WEBER) BRITTON AND ROSE) ISOLATES USING 2,2-DIPHENYL-1-PICRYLHYDRAZYL METHOD
Authors: Wahdaningsih Sri , Wahyuono Subagus , Riyanto Sugeng , Murwanti Retno
Published: January 2018

Objective: Indonesia is a country which has various natural resources including medicinal plants. Among the plants, red dragon fruit is interesting to be studied. In this study, antioxidant activity of red dragon fruit peel (Hylocereus polyrhizus (F.A.C. Weber) Britton and Rose) isolate was tested using 2,2-diphenyl-1-picrylhydrazyl method.Methods: Isolation of active compounds was performed through the application of vacuum liquid chromatography and preparative thin-layer chromatography (TLC). Antioxidant activity was tested using both TLC and spectrophotometry.Result: Results revealed that the values of IC50 of isolate 1 and 2 were 2.952, 14 μg/mL and 25.635,95 μg/mL, respectively.Conclusion: Isolate of dragon fruit has antioxidant activity. The compound which results in antioxidant activity is terpenoid and steroid.
IMPLEMENTATION AND SYSTEMATIZATION OF A COMPREHENSIVE MEDICATION MANAGEMENT (CMM) SERVICE DELIVERED TO WOMEN WITH BREAST CANCER
Authors: Ribeiro Maria Angela , Mendonça Simone Araújo Medina , Filardi Agnes Ribeiro , Dos Anjos Anna Claudia Yokoyama , De Oliveira Djenane Ramalho
Published: January 2018

Objective: The aim of the present study was to describe the process of implementation and systematization of a comprehensive medication management (CMM) service, from the perspective of the participants involved, in a high complexity service that cares for women with breast cancer in Brazil.Methods: A qualitative study that utilized action research that followed the procedures proposed by Kurt Lewin and the ethical and clinical principles of pharmaceutical care practice. Data collection techniques were participant observation between August 2014 and December 2016, semi-structured interviews with eight pharmacists and pharmacy residents, field notes, and analysis of documents.Results: Six major themes emerged in four cycles of the action research process: (1) Resistance is human; the management of conflict is necessary; (2) insecurity with being a clinician; (3) management of change supported by driving forces; (4) pharmaceutical care fostering professionals’ self-efficacy; (5) documentation as the conducting wire of the practice; and (6) the advantages of a systematized practice.Conclusion: The study offered an understanding of the process of implementation of CMM services from the perspective of pharmacists. It produced knowledge on the experiences of pharmacists as they lived through the process of transformation of their professional practice to offer a patient-centered and systematized service. The framework of Lewin supported the introduction of a new work path for pharmacists, which could be operationalized as an innovative technology for the Brazilian health-care system: CMM services.
CARDIOPROTECTIVE EFFECT OF INDIGOFERA TINCTORIA LINN. AGAINST MYOCARDIAL INFARCTION-INDUCED RATS
Authors: Puligilla Shankaraiah , K Priyanka
Published: January 2018

Objective: The aim and objective of the present study are to study the protective effects of ethanolic extract of Indica tinctoria (EEIT) in isoproterenol-induced acute myocardial infarction (AMI) in rats.Methods: The effect of two doses of isoproterenol (5 mg/kg and 8.5 mg/kg body weight) changes in aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and total protein (TP) and lipid hydroperoxides, superoxide dismutase (SOD), and glutathione (GSH) in blood serum and heart homogenate, for the two consecutive days (29 and 30), were administered subcutaneously in rats in pre-treatment with EEIT for the 28-day study.Results: There was increased the AST, ALT, LDH, CPK, and lipid peroxides levels and decreased the TP, SOD, GSH with Isoproterenol-induced group. Pre-treatment for 28 days with Indigofera tinctoria significantly (p<0.05) increased antioxidants (SOD , GSH) , TP levels and decreased the cardiotoxic agents significantly (p<0.05) such as LPO, AST, ALT, LDH, and CPK levels in treatment groups.Conclusion: I. tinctoria contains beneficial bioactive photochemicals that have been protective effective against isoproterenol-induced AMI in rats.
CYTOCHROME P450 CYP1B1*2 GENE AND ITS ASSOCIATION WITH T2D IN TABUK POPULATION, NORTHWESTERN REGION OF SAUDI ARABIA
Authors: Elfaki Imadeldin , Almutairi Fahad M , Mir Rashid , Khan Roaid , Abu-duhier Faisel
Published: January 2018

Objective: Cytochrome P450 1B1 (CYP1B1) is involved in the activation of procarcinogens and steroid metabolism. Genetic variants of CYP1B1are associated with altered catalytic activity and disease phenotypes. The purpose of this study was to investigate the role of CYP1B1 (rs1056827) polymorphism in inducing T2D.Methods: This cross-sectional study enrolled 113 subjects of T2D and 120 controls. DNA was isolated from blood. Genotyping of the rs1056827 wasdone by allele-specific polymerase chain reaction. The frequency of alleles and genotype distribution was compared in T2D cases and healthy controls.Statistical analysis was performed with SPSS, Chi-square, and Fisher exact test. Hardy-Weinberg equilibrium was tested by a χ2 test. The associations between rs1056827 variant genotypes and T2D were estimated by computing the odds ratios and their 95% confidence intervals (CI) from univariate and multivariate logistic regression analysis.Results: A significant association of rs1056827 was found between T2D cases and controls (p<0.0001). When GG genotype was compared with GT genotype a significant association was found with odd ration (OD)0.24 (95% CI: (0.131–0.452) and risk ratio (RR) 0.45 (0.30–0.67) times the risk of T2D heterozygous with the G/T allele (p≤0.0002). In a comparison of GG homozygous with the TT homozygous, there was no significant association with the OD 0.38 (95% CI: (0.02–6.51) RR 0.55(0.13–2.35), p<0.49. When G allele was compared with the T allele a highly significant association with OD 0.54 (95% [CI]: (0.37–0.80) RR 0.75(0.630–0.897) < p≤0.003 suggesting a possible dominant effect of this polymorphism on T2D risk.Conclusion: This result suggests a significant association between rs1056827G>T polymorphism and T2D. This finding is limited due to the smaller sample size and can be validated by large sample size studies.
NEUROCHEMICAL ASSESSMENT AND BEHAVIORAL ROLE OF TUBEROINFUNDIBULAR PEPTIDE-39 IN ACUTE RESTRAINT STRESS-INDUCED DEPRESSION IN RATS.
Authors: V Sankar , M Ramanathan , G Venkatesh
Published: January 2018

Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model.Methods: Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard.Results: The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats.Conclusion: Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.