bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepção das instituições que necessitam dar a alta para pacientes com paralisia cerebral que completam a maioridade: barreiras e facilitadores
Authors: Skilhan de Almeida Carla , Bernadete Castellã Pergher Simone
Published: June 2023

Introdução: O tema paralisia cerebral (PC) é importante e bem explorado pelos estudos atuais em crianças. No entanto, as crianças crescem e tornam-se adultas. Para este tema, carecemos de estudos. Verificamos que, quando a criança PC chega à maioridade recebem alta das instituições que eram acompanhadas até então. Objetivo: Verificar qual a percepção das instituições que atendem o público infantil com PC quando os mesmos recebem alta por idade. Identificar quais as barreiras e facilitadores encontrados. Métodos: Trata-se de uma pesquisa qualitativa do tipo estudo de caso institucional, onde três instituições de Porto Alegre que atendem um público infantil (sem custo) responderam um questionário sobre a percepção da alta do paciente PC por limite de idade. A amostra foi não probabilística intencional. A análise de conteúdo baseada na percepção, facilitadores e barreiras, seguiram o modelo de Bardin. Foram criadas nove categorias para realizar a interpretação dos questionários. Resultados: As instituições encaminhavam seus pacientes após a alta para outras instituições que atendem adultos; a carência destas foi uma das barreiras encontradas; mas o vínculo criado com a família foi um facilitador. Ao dar alta, a instituição fica triste, emocionada e grata pela confiança das famílias. Conclusão: as instituições pesquisadas indicam seus pacientes para a continuidade de tratamento em outros locais; a dificuldade de haver mais locais especializados para continuarem o tratamento; sentem-se emocionados pelo vínculo adquirido ao longo dos anos com as famílias e acreditam ser um fator positivo dar alta aos pacientes para oportunizar tratamento a outras crianças com PC.
MÉTODO DOS ELEMENTOS DISCRETOS APLICADO A SIMULAÇÃO DO ESCOAMENTO DO FERTILIZANTE NPK REVISÃO SISTEMÁTICA
Authors: Telocken Alex Vinícios , Binelo Manuel Osorio
Published: June 2023

No Brasil, uma das principais fontes de receitas é o agronegócio, sendo o responsável por uma parcela representativa de 33% do Produto Interno Bruto em 2016. No agronegócio, o cultivo de vegetais concebe grande parte desta parcela. Isso se deve a alta produtividade de grãos e outros vegetais, a qual, está diretamente ligada a utilização de fertilizantes. O uso eficiente, considerando tanto rentabilidade, quanto o impacto ecológico deve ser previamente mensurado. Neste sentido, o estudo aqui externado é parte integrante da tese em desenvolvimento que tem o objetivo de, por meio da utilização do Método de Elementos Discretos, modelar o escoamento de uma semeadora-adubadora. Para alcançar o objetivo geral da tese, o presente artigo apresenta uma revisão sistemática de trabalhos que seguem o tema da modelagem matemática ou computacional do objeto previamente exposto. Assim, foram avaliados os trabalhos objetivando identificar as metodologias que foram utilizadas na modelagem do escoamento de fertilizantes. Também, foram analisadas outras técnicas de mensuração de escoamento que podem ser inseridas na implementação do modelo matemático e computacional de um dosador helicoidal.
Contribution of YPRO15C Overexpression to the Resistance of Saccharomyces cerevisiae BY4742 Strain to Furfural Inhibitor
Authors: Abrha Getachew Tafere , Li Qian , Kuang Xiaolin , Xiao Difan , Ayepa Ellen , Wu Jinjian , Chen Huan , Zhang Zhengyue , Liu Yina , Yu Xiumei , Xiang Quanju , Ma Menggen
Published: June 2023

Lignocellulosic biomass is still considered a feasible source of bioethanol production. Saccharomyces cerevisiae can adapt to detoxify lignocellulose-derived inhibitors, including furfural. Tolerance of strain performance has been measured by the extent of the lag phase for cell proliferation following the furfural inhibitor challenge. The purpose of this work was to obtain a tolerant yeast strain against furfural through overexpression of YPR015C using the in vivo homologous recombination method. The physiological observation of the overexpressing yeast strain showed that it was more resistant to furfural than its parental strain. Fluorescence microscopy revealed improved enzyme reductase activity and accumulation of oxygen reactive species due to the harmful effects of furfural inhibitor in contrast to its parental strain. Comparative transcriptomic analysis revealed 79 genes potentially involved in amino acid biosynthesis, oxidative stress, cell wall response, heat shock protein, and mitochondrial-associated protein for the YPR015C overexpressing strain associated with stress responses to furfural at the late stage of lag phase growth. Both up- and down-regulated genes involved in diversified functional categories were accountable for tolerance in yeast to survive and adapt to the furfural stress in a time course study during the lag phase growth. This study enlarges our perceptions comprehensively about the physiological and molecular mechanisms implicated in the YPR015C overexpressing strain’s tolerance under furfural stress.

Construction illustration of the recombinant plasmid. a) pUG6-TEF1p-YPR015C, b) integration diagram of the recombinant plasmid pUG6-TEF1p-YPR into the chromosomal DNA of Saccharomyces cerevisiae.
The Molecular Approaches and Challenges of Streptococcus pneumoniae Serotyping for Epidemiological Surveillance in the Vaccine Era
Authors: Abdul Rahman Nurul Asyikin , Mohd Desa Mohd Nasir , Masri Siti Norbaya , Taib Niazlin Mohd , Sulaiman Nurshahira , Hazman Hazmin , John James
Published: June 2023

Streptococcus pneumoniae (pneumococcus) belongs to the Gram-positive cocci. This bacterium typically colonizes the nasopharyngeal region of healthy individuals. It has a distinct polysaccharide capsule – a virulence factor allowing the bacteria to elude the immune defense mechanisms. Consequently, it might trigger aggressive conditions like septicemia and meningitis in immunocompromised or older individuals. Moreover, children below five years of age are at risk of morbidity and mortality. Studies have found 101 S. pneumoniae capsular serotypes, of which several correlate with clinical and carriage isolates with distinct disease aggressiveness. Introducing pneumococcal conjugate vaccines (PCV) targets the most common disease-associated serotypes.

Nevertheless, vaccine selection pressure leads to replacing the formerly dominant vaccine serotypes (VTs) by non-vaccine types (NVTs). Therefore, serotyping must be conducted for epidemiological surveillance and vaccine assessment. Serotyping can be performed using numerous techniques, either by the conventional antisera-based (Quellung and latex agglutination) or molecular-based approaches (sequetyping, multiplex PCR, real-time PCR, and PCR-RFLP). A cost-effective and practical approach must be used to enhance serotyping accuracy to monitor the prevalence of VTs and NVTs. Therefore, dependable pneumococcal serotyping techniques are essential to precisely monitor virulent lineages, NVT emergence, and genetic associations of isolates. This review discusses the principles, associated benefits, and drawbacks of the respective available conventional and molecular approaches, and potentially the whole genome sequencing (WGS) to be directed for future exploration.
Effects of Different Wall Openings on the Cyclic Behavior of Aerated Concrete Block Infilled RC Frames
Authors: Aykanat Batuhan , Arslan Mehmet Emin , Şen Anıl
Published: June 2023

In the current study, the effects of infilled reinforced concrete (RC) frames with different window and door openings under cyclic loads were investigated. For this purpose, five in-filled RC frames with different infill wall openings were produced. The main parameters to evaluate overall performance of the RC frames with infill walls, the load carrying capacities, displacement ductility, stiffness degradation and energy dissipation capacities were determined using obtained results. At the end of the study, even if the opening ratios are the equal, it has been observed that the location and number of openings have a significant effect on the behavior and failure pattern of the RC frames. Also, increase in the openings ratio decreases the load carrying capacity, and energy consumption capacity. Based on these results, it is suggested that infill walls affect the structural behavior and failure pattern. Therefore, infill wall openings should be considered in the design of RC structures.
Institutional Leadership Commitment and Eradication of Mental Illness Stigmatization among Students of Kenya Medical Training College
Authors: Maina J. Kamau  , Kenneth Goga Riany
Published: June 2023

Leadership is the main driver of organizational behavior and how people relate in an organization. Through the commitment of institutional leaders to a given culture and way of doing things, the entire organization community is possible to follow the direction the leaders shows. While mental illness has been a major threat to the stability of modern society, the focus has mainly been drawn on treatment, while other affecting factors such as stigmatization not being given the adequate attention. Stigmatization of mentally ill persons is a behavior that requires intensive management by the organizational leaders for it to be contained. Leaders influence behavior, thus their commitment to eradicate mental illness stigmatization would be fundamental in curbing mental illness stigmatization. With inadequate literature on the role played by leadership commitment in curbing mental illness stigmatization, this study seeks to assess the role of institutional leadership on mental illness stigmatization. The study used a descriptive research approach and a questionnaire to collect data from 384 students drawn from a population of 51045 students at the college. The data was analysed using descriptive and inferential statistics through SPSS. The findings revealed that the commitment of institutional leadership in curbing mental illness stigmatization was essential in reducing stigmatization of mentally ill persons. The study concluded that through the commitment of leaders by training and creating awareness was significant in curbing mental illness stigmatization. It is recommended that the institutional leaders have a duty to play in curbing mental illness stigmatization through creation of awareness, training of the students and providing psychosocial support to mentally-ill persons.
Current conditions of subsoil use in the mining industry of Ukraine
Authors: Sobko B , Lozhnikov O
Published: June 2023

Purpose. To conduct an analysis and determine the peculiarities of subsoil use in the conditions of the current state of the mining industry of Ukraine. Research methodology. Analytical and statistical methods were applied during the research in the modern conditions of relations between subsoil users and state institutions at the mining deposits of mineral resources. The results. The work examines the peculiarities of the modern state of subsoil use, the order, sequence and terms of issuing and obtaining permits for the development of mineral deposits. It has been established that the country still lacks a regulatory and regulated "integrity" of the procedure for the emergence of a practical possibility for a business entity to realize its right to develop a deposit. After obtaining a special permit for the use of subsoil, mining enterprises must obtain a whole series of permit documentation at least over several years. It was determined that in the process of working out the deposits, the enterprises of the mining industry of Ukraine constantly face problems related to the imperfection and frequent changes of the current legislation. Today, it is necessary to establish at the legislative level a specific list of necessary documents, an algorithm of actions and a period during which, after obtaining a special permit for the use of mineral deposit, state bodies are obliged to issue the remaining necessary permit documents, which would contribute to the solution of the above-mentioned problematic issues. It was determined that for the effective and sustainable operation of mining enterprises, it is important to settle the issues at the legislative level: - overcoming the problem of "dormant licenses"; - introduction of international stock assessment (SPE-PRMS, JORC); - abolition of the institution of mining claim territories (a mining claim does not solve any issues, it simply duplicates the functions of a special permit for the use of mineral deposits and a project of deposit mining); - to develop and adopt a new Code on the Subsoil of Ukraine. Scientific novelty. Consists in establishing the peculiarities of subsoil use in the conditions of the modern state of the mining industry of Ukraine, determining the order, sequence and term of issuing and obtaining permits for the development of mineral deposits. Practical value. The results of the research made it possible to determine the algorithm for the registration, approval and approval of permit documents for the development of mineral deposits, starting with a special permit for the use of subsoil; the procedure for obtaining a mining right-of-way certificate; registration of title documents for land plots for the mining of mineral deposits; development of the construction and operation project of the mining enterprise, its examination and approval by the relevant state institutions.
Calculation of the strength of cast and packaged concrete protective walls
Authors: Krukovskyi O , Kurnosov S , Makeiev S , Stadnichuk M
Published: June 2023

Purpose. The substantiation of the compliance of the selected cement-mineral mixture with the mining and geological conditions of the working location when calculating the parameters of cast or packaged walls, considering the intensity of concrete hardening over time, the compliance of the set strength of concrete with the expected load. Method. To substantiate the compliance of the physical and mechanical properties of the pressure mixture on the means of protection of the production from the side of the fake roof of the coal seam, the values of the limit strength of concrete for uniaxial compression, obtained according to standard tests in laboratory conditions, are used. At the same time, concrete samples are subjected to uniaxial compression, the surfaces of which must be smooth and parallel, which does not correspond to the mine conditions for the construction and operation of cast and packaged protective walls. Quick-hardening liquid mixtures are used in the construction technologies of cast and packaged security walls. For some time, necessary for the hardening of concrete, they are not able to perceive the pressure from the rocks forged by longwall. Therefore, the criterion for evaluating the stability of cast or packaged walls is the correspondence of the rate of growth of the strength limit of the wall to uniaxial compression with the load from the forged roof of the coal seam at the moment of timeτ. Results.The importance of the impact on the strength limit of the concrete wall of each of the factors that create the risk of its destruction has been established. At the same time, the ranges of change of these factors are considered. The largest influence (up to 33%) is exerted by the coal seam capacity factor km. The scientific novelty of the work consists in the integration of the influence coefficients of the factors that create the risk of destruction of the concrete protective wall: its structure; relief of forged and crushed rocks pressing on the wall; chemical aggressiveness of mine water, which is used to dissolve the mixture; the temperature of the mine environment and the power of the coal seam to obtain a formula for calculating the growth of wall strength over time. The practical significance of the work lies in the improvement of the method of calculating the strength of concrete protective walls over time by considering the factors that form the mine conditions of their construction and operation.
Technology of combined fixing of preparatory products for efficient use of suspended monorail roads
Authors: Shyrin L , Herasymenko A , Koptovets O , Felonenko S
Published: June 2023

Purpose. Justification of the parameters and design of the system of combined fastening of the monorail pond of the suspended monorail roads in formation underground workings to reduce dynamic loads on the elements of the arch fastening and the mining massif during the delivery of large-tonnage loads and equipment to preparatory pits and assembly chambers. The methods. The recommended method of substantiating the technological schemes of auxiliary transport, focused on the use of multifunctional mining equipment of the new generation, adapted to the modern conditions of performing assembly and dismantling works and preparing new mining pillars for cleaning extraction, which is based on the modeling of the parameters of the interaction of the rolling stock of suspended monorail roads with arch fastening elements and side rocks during transportation of large-tonnage cargoes. Findings. According to the results of research into the operational parameters of suspended monorail roads as part of a highly adaptive transport and technological system for the delivery of large-tonnage cargo, it was established that to reduce dynamic loads on the elements of the arch fastening and the mining massif in the specific conditions of the mines of Western Donbass, the most promising option is the two-level anchor fastening of the monorail stand and preparatory product. The originality. Innovative technical solutions to increase the operational reliability of the arch attachment during the transportation of large-tonnage loads and reduce dynamic loads on the mining massif by redistributing them to adjacent links of the monorail pond and modernizing the transport and technological system are substantiated. Practical implementation. It has been proven that during the intensification of cleaning and preparatory work, reasonable technical and technological solutions meet the requirements for the timely preparation of new mining pillars and are considered as a promising direction for improving the current schemes of auxiliary transport for the mines of the region and ensuring the operational parameters of mining transport equipment of a high technical level in the specific conditions of the mines of the Western Donbass.
Features of development of the collection stone' current market
Authors: Shevchenko S , Yastrebov D , Sak M , Moskalenko A
Published: June 2023

Purpose. On the basis of open sources of information, perform an analysis of the factors that led to an increase in the demand for collectible mineral specimens, identify the current popular trends in this market, show the potential of Ukraine in this field. The methods. The work uses general scientific research methods - empirical and theoretical (analysis, generalization, comparison, explanation). Findings. The main factors that led to the current increase in demand for collectible stones are highlighted, including the development of information technologies, the Internet, and social networks. Popular trends are identified and their connection with investment activities is shown, in particular such areas as museum and exhibition activities, cryptocurrencies, NFT technologies. A preliminary analysis of the availability and distribution of specimens of collection stones of Ukraine in modern museum collections of the world was performed, examples of the use of collection samples from the deposits of Ukraine as raw materials by the world's leading carvers are given, such a phenomenon as the activity of hunters, including at well-known domestic geological sites, is highlighted. The originality. The market for collectible mineral specimens is shown to be a powerful segment of the global gems market with annual sales of over $1 billion. Its capitalization continues to increase thanks to the artistic reinterpretation of these unique works of nature, the collections of which are now considered as alternative investments with the value of individual specimens at the level of 500 million dollars. The discovery of new mineral deposits, the emergence of a new class of collectors, as well as the development of cryptocurrencies justify the further development of collectible specimens’ market. Practical implementation. Examples of the commercialization of collectible specimens with the application of NFT technologies to them or to their digital images are given, usingof images of the specimens in modern art is shown on specific works of domestic and foreign artists and graphic products. Modern approaches to the formation of museum collections in the world's leading museums, the principles of philanthropy and aspects of attracting patrons, as well as the experience of attracting a wide range of visitors, which should also be applied to domestic state and university museum collections, are shown.
Mathematical substantiation of mine locomotive braking efficiency under pulsiting braking torque
Authors: Monia A
Published: June 2023

Purpose. Determination of braking torque parameters that provide high braking performance of a mine locomotive by mathematical modeling of the braking of a mine locomotive by a disc brake that creates a pulsating braking torque. The methods. Forced vibrations of the elements of the wheel-motor unit (WMU) of a mine locomotive in the process of braking with a disc brake are studied by the methods of differential calculus and mathematical modeling. Integration of the system of differential equations is performed by the Runge-Kutt method. Findings. A comparative analysis of a mine locomotive braking by a disc brake, which creates a constant and pulsating sinusoidal braking torque with a different number of sinusoid periods per revolution of the wheel pair, is carried out. It has been proved that the pulsating sinusoidal braking moment generated on the axle of the wheel pair equal to the sum of the constant component and the amplitude of the oscillations of the variable component multiplied by the sine of the product of the number of sinusoid periods per revolution of the wheel pair by its angular coordinate provides higher braking characteristics than the constant braking moment. It is shown that pulsating braking torque reduces the braking time and braking distance of the mine locomotive. The values of the amplitude of oscillations, which depend on the average value of the braking torque, and the number of periods of the sinusoid per one revolution of the wheelset, at which the greatest effect is achieved, are determined. The originality. For the first time, a mathematical model has been developed for braking a mine locomotive by a disc brake, which creates a pulsating braking torque on the axle of the wheel pair, depending on its angular coordinate, taking into account the nonlinear dependence of the adhesion coefficient on relative slip, on the basis of which the efficiency of a disc brake with a multi-sector disc is shown in comparison with a disc brake with a homogeneous disk under various conditions of the rail track. Practical implementation. The research results make it possible to determine the parameters of a disc brake with a multi-sector disc located on the wheelset axle and on the engine shaft, which provide the highest braking efficiency.
Analytical approach to solving the problems of nonlinear dynamics of systems with time-varying parameters under the conditions of the external environment reaction
Authors: Aziukovskyi O , Harkavenko D , Gristchak V , Ziborov K , Fedoriachenko S , Odnoral M
Published: June 2023

Purpose. The development and application of analytical (including approximate) methods of analyzing nonlinear mathematical models of system dynamics, which have complex behavior due to the presence of time-dependent characteristics, is relevant for solving various classes of engineering problems. Therefore, the purpose of this work is mathematical modeling of problems of nonlinear dynamics of such systems, which allows determining the trajectory of the system's movement over time and other dynamic characteristics in accordance with their setting. Method. Based on the modern achievements of analytical, in particular asymptotic and numerical research methods based on existing software complexes, the possibility of non-local research and the formation of a sufficiently complete representation of the peculiarities of the behavior of nonlinear systems is considered. To achieve the goal, a mathematical model of the nonlinear dynamics of a system with time-varying properties is considered, provided that the reaction of the environment depends on the function of the speed of movement of the system to the n degree. The results. The solution of some engineering problems of the nonlinear dynamics of systems with time-varying characteristics of dependence for n=2 and systems whose response to the external environment can be a function of both whole and fractional degrees allow to determine the trajectory of the system's movement over time and other dynamic characteristics in accordance with before their production. Scientific novelty. The analytical dependence of the speed function of the dynamic process of the system with time-varying parameters was obtained for the nonlinearity parameter of the studied system most used in practice, n=2, for the reaction function of the external environment. Practical significance. The obtained analytical dependencies can be applied in a sufficiently wide range of research. Approximate analytical methods based on asymptotic approaches based on hybrid methods (perturbation, phase integrals in combination with Galerkin's principle) are applied. The use of asymptotic and numerical methods of research based on existing software complexes opens up the possibility of non-local research and the formation of a sufficiently complete representation of the peculiarities of the behavior of nonlinear systems with variable characteristics of materials, in particular, composite and functionally gradient ones.
Acid systems usage for inflow intensification technologies experimental justification
Authors: Aheicheva O
Published: June 2023

Purpose. Research and experimentally substantiate the use of acid systems for inflow intensification technologies. To study the peculiarities of the mechanisms and methods of restoration of the near-outbreak zone of the reservoir. The methods. 1. Diagnosis of the causes of deterioration. 2. Selection of appropriate reagents for processing. 3. Selection of the method of delivery of the agent into the reservoir (design). 4. Modeling (calculation). 5. Prediction of the final productivity of the well. Findings. There are some physical means of diverting the injected acid composition for selective treatment, which include: the use of rubber-coated balls added to the injected fluid composition to plug the receiving holes, and the use of packers that isolate the zone necessary for cleaning during operation from the rest of the wellbore. Mechanical methods of selective cleaning differ from others in that they completely cover non-target intervals, directing the entire flow of the reagent to the open area. The originality. Increasing the effectiveness of the influence of hydrochloric acid solutions on the near-cut zone of wells is one of the factors in the effective development of oil deposits in carbonate reservoirs. To solve this problem, geological and technological justification of the choice of wells and technological parameters of influence in specific geological conditions of the deposits is necessary. Practical implementation. A significant number of technologies proposed today for the intensification of the subsurface zone with hydrochloric acid indicate a great variety of productive layers in terms of their occurrence, geological-physical and physico-chemical properties of reservoir rocks and fluids that saturate them, differences in development technology that must be taken into account when influencing increasing its efficiency. Acid treatment is one of the traditional and generally accepted methods of restoring by dissolving the rock and the subsequent formation of highly permeable channels. In order to maximize the effect of the treatment, the active part of the composition (acid) should be redistributed to evenly treat all clogged areas, and the entire composition after working out should be easily removed at the stage of washing and development after the operation.
Drilling mechanical hydrogen extraction at mining enterprises of Ukraine
Authors: Davydenko O , Ahaiev R , Shypunov S , Yavorska V , Kononov M
Published: June 2023

Purpose. Increasing the technical and economic indicators of well mechanohydraulic production due to the selection of the type and optimal formulation of drilling flushing fluids. In today's conditions, the lack of energy carriers requires involving a wider range of natural phenomena in energy production, looking for reliable ways and methods of increasing the efficiency of production. The use of energy also forces the introduction of resource-saving, environmentally safe geotechnologies in the energy-intensive technological processes of mining, transportation, crushing and beneficiation of minerals in the conditions of powerful mining enterprises of Ukraine. The methods. The study of the features of the creation and implementation of a progressive complex hydraulic program for the construction of wells was carried out using modern methods of analytical analysis and experimental research, in particular by using general principles of mathematical and physical modeling, methods of processing research results in the environment of МАТHCAD, control and measuring devices and materials. Findings. Development and operational implementation of justified resource-saving ecologically safe geotechnologies and environmental protection strategies. Flushing fluid treated with direct current can be used to increase the technical and economic indicators of the well drilling process. The originality. Dependencies have been established that describe the process of formation under the influence of a rock-destructive tool of individual rock particles that are exposed to the action of the boundary layer, and others that fall into the zone of action of the laminar sublayer. A dependency has been established that describes the process of leaving parts of the sludge that are not carried away by the flow of washing liquid, which, in turn, leads to its further grinding and increased wear of the rock-crushing tool. Practical implementation. Data were obtained on the adsorption reduction of hardness, which is a consequence of the increase in the affinity of the collapsing rock to the washing liquid. This is reflected in the intensive binding of water (hydrate) shells on the inner surface of microcracks or in their mouths. The parameters for improving the efficiency of iron ore extraction in the conditions of deposits of Ukraine are given and substantiated, in particular, a careful approach to the process of regulating the pH level of cleaning agents, taking into account the geological and technical conditions of drilling operations and the intended purpose of wells
Mathematical model of waste accumulation in Ukraine
Authors: Rusakova T
Published: June 2023

Purpose. Analysis and generalization of waste sources as factors that form the total volume of accumulated waste in Ukraine, which negatively affects the environment. Construction of a mathematical model of waste accumulation in Ukraine based on the results of the calculation of statistical indicators. Conducting research on the influence of selected factors on each other in order to avoid the phenomenon of non-collinearity or multicollinearity in the calculations. The methods. The application of multiple correlation-regression analysis methods for modeling, which allow, on the basis of the analysis of the studied statistical indicators, to single out the most statistically significant factor values, to assess the relationship between them and the relationship of these factor values with the resulting characteristic, which provides prerequisites for building a mathematical regression model. Findings. On the basis of descriptive statistics, an analysis of each of the studied factor values, such as generated, utilized, burned, removed waste, is presented, and the trends of their changes during 2010-2020 of years are established. The results of the correlation-regression analysis of statistical data are presented: the density of correlation relationships between the selected factor variables and the resulting variable; coefficient of linear determination; a measure of the quality of the regression equation. Those factor variables with weak correlation or multicollinearity were removed. A mathematical model based on regression-diffusion analysis was obtained and its adequacy was checked, the average relative error of the calculated data was 6 %, the maximum relative error was 10 %. The linear mathematical model was improved due to the introduction of non-linear variables, the average relative error of the calculated data was 3 %, the maximum relative error was 8 % Theoriginality. Dependencies and regularities have been established for the volumes of generated, utilized, incinerated and removed waste. A multifactorial mathematical model has been developed that establishes a relationship between different types of waste and the total amount of accumulated waste, which tends to increase, and this, in turn, increases the negative impact on the environment. Practical implementation. Mathematical apparatus for forecasting the total amount of accumulated waste due to the combined effect of generated, utilized, burned, removed waste and their combination, which is important when estimating the size of areas for accumulating waste and creating perspective plans for their disposal.
Papillary Tumor of Pineal Region: A Case Report
Authors: Khaled Ahmed , Alam SM Mahbubul
Published: June 2023

Pineal region tumors constitute about 0.4%-1% of intracranial tumors in adults. These tumors may arise from pineal gland itself or structures around it which are all termed as pineal region tumor. Papillary tumor of the pineal region is a non-parenchymal tumor of the pineal region. First described in 2003, it is an extremely rare tumor. We have presented a case of 27-year-old female patient presented as a pineal tumor. After successful excision, the tumor proved to be Papillary tumor of Pineal region (PTPR) both histomorphologically and immunohistochemical study.

Pulse Volume 12-14 2020-2022 p.13-15
Frontalis Suspension Surgery for Patients with Essential Blepharospasm Unresponsive to Botulinum Toxin Injections
Authors: Yeo Sujin , Woo Kyung In , Kim Yoon-Duck
Published: June 2023

Purpose: To report the efficacy of frontalis suspension using a silicone rod or preserved fascia lata for patients with blepharospasm who exhibit persistent symptoms and visual dysfunction unresponsive to botulinum injections.Methods: The clinical records of five patients (10 eyes) with essential blepharospasm who underwent frontalis suspension were reviewed. Patients who continued to report eyelid-opening difficulties despite prior administration of botulinum toxin were included.Results: The mean patient age was 60.2 years; and 40% of the patients were women. The frontalis was suspended using silicone rods (n = 3) or preserved fascia lata (n = 2). Blepharospasm frequency and severity were measured using the Jankovic Rating Scale (JRS). Compared with preoperative scores, the summed JRS scores decreased 1 week, 1 month, and 3 months after surgery. Postoperatively, two patients (40%) did not require further botulinum toxin injections. In three patients, the intervals between injections were increased after surgery. No patient experienced any significant complication.Conclusions: Frontalis suspension is safe and effective for patients with blepharospasm and apraxia of eyelid opening, who have not responded to botulinum toxin injections.
Ocular Manifestations Associated with Cerebral Vein Sinus Thrombosis Developing after SARS-CoV-2 Vaccination
Authors: Mun Junho , Choi Hyeon Gyu , Kim Kyoung Lae , Choi Youn Joo
Published: June 2023

Purpose: We report a case of neuroretinitis combined with external ophthalmoplegia in a patient who developed a cerebral venous sinus thrombosis after administration of a SARS-CoV-2 vaccine.Case summary: A 26-year-old woman who was on oral contraceptives was diagnosed with a cerebral venous sinus thrombosis 1 month after the first injection of a SARS-CoV-2 vaccine (BNT162b2, Pfizer-BioNTech). The levels of factors 8 and 9 were elevated on the blood test. The corrected visual acuities were 0.3 in both eyes. A complete limitation of abduction and esotropia were evident in the left eye. Both eyes exhibited optic disc swelling and hemorrhage and retinal nerve fiber layer swelling. Subretinal fluid was apparent in the right eye. Three weeks later, the optic disc swellings and hemorrhages had worsened and both eyes evidenced macular stars. After 10 months, the corrected visual acuities improved to 0.9 in both eyes. Ocular motor function and the esotropia also improved. However, the overall contraction of the visual field did not.Conclusions: SARS-CoV-2 vaccination can trigger cerebral venous sinus thrombosis, neuroretinitis, and external ophthalmoplegia. In patients with risk factors for such thrombosis, the possibility of ophthalmic complications should be considered after administration of a SARS-CoV-2 vaccine.
Fundamental Changes and Their Impact on the Concept of Children's Education from Parents' Interpretations
Authors: Chicevic Simona , Kostrub Dusan
Published: June 2023

Education as a purposeful activity has its complexities and goals, and its process should be equipped with pedagogical principles. In the presented study, based on the authors' interviews with the subjects, the authors’ aim is to identify the prevailing educational views of parents in the upbringing of their children; the views of grandparents in the upbringing of their grandchildren, and the critical moments influencing their conscious decision-making and behaviour related to their beliefs as parents and grandparents. Qualitative research tools were used to obtain research material, namely unstructured and subsequently semi-structured interviews. The strategy of the constant comparison method was applied in elaborating the research material. The research was carried out in Slovakia and the Czech Republic and was attended by parents and grandparents (total number: 11) of children and grandchildren aged 2-6 years. The findings show that parents' and grandparents' beliefs about the definition and meaning of education coincide in many aspects. On the other hand, they differ significantly in other aspects, such as destructive influences on the child or the beginning of education. From the theory derived from the research, the fact emerges that the belief and the forming educational thinking of the subjects of the research are influenced by the specific experience in raising their children and, at the same time, the education experienced during childhood. This fact is primarily based on the identified interrelationships between the individual categories of the investigated phenomena, while it is based exclusively on the statements of the subjects of this longitudinal research.
Factors and Reasons Influencing Thai EFL University Students' Use of Language Learning Strategies
Authors: Parichart Toomnan
Published: June 2023

The present study has the following goals:  1) To consider the variety of language learning strategies and their relative frequencies as chosen by English majors studying at public universities in the northeast of Thailand; 2) to understand what may be the underlying factors that guide these choices as reported by the participants; and 3) to answer why those strategies and their frequencies.  The participants were 579 students at 6 public universities in the northeast of Thailand, all of whom majored in English. The tools to gather the data were a background information questionnaire, LLS questionnaire and semi-structured interviews.  A selective sample of 30 participants took part in the guided lightly-structured interviews.  The tools used for a quantitative analysis were obvious descriptive data and factor analysis. Further analysis of the qualitative results were done using content and thematic analyses.  The quantitative results tell us that their overall use of language learning strategies were at a predictable moderate frequency of overall use and only small variations at category levels. At the individual level, high frequencies were reported for 6 strategies, moderate usage for 37 strategies and infrequent to zero usage were shown for 2 strategies.  Four underlying factors where derived from a factor analysis. The qualitative results revealed that 16 reasons can be ascertained for the frequent use of certain strategies, and 3 reasons for infrequently used strategies.
Os efeitos cognitivos apresentados pela síndrome pós-COVID-19: Uma revisão sistemática
Authors: Santana Adna Jwklezya de , Pereira Clayrton de Barros , Andrade Fernanda Teixeira de , Pinto Gabriel Malvezzi da Silva , Marques Giovana Dutra , Santos Júnior Nilton Nascimento dos
Published: June 2023

Introdução: a síndrome pós-COVID-19 trata-se do termo aplicado a diversos sintomas, alguns cognitivos, persistentes da COVID-19, mesmo após o final da fase aguda da infecção. Objetivo: apresentar os efeitos cognitivos da síndrome pós-COVID-19 por meio de dados coletados e analisar a relação entre a infecção do SARS-CoV-2 e o desenvolvimento dessas manifestações clínicas. Metodologia: foi realizada uma revisão sistemática de literatura, com base na busca de ensaios clínicos nos portais PubMED e Scielo. Seis estudos foram selecionados para a revisão. Resultados: no geral, os estudos acerca dos efeitos cognitivos da síndrome pós-COVID-19 foram pequenos e se basearam em testes e autoavaliações, mas mostram que confusão mental, perda de memória e dificuldade de concentração são as principais queixas relatadas pelos pacientes. Discussão:  evidências apontam que os efeitos cognitivos da síndrome pós-COVID-19 podem estar relacionados com a gravidade da infecção pelo COVID-19 e a doenças neurológicas prévias. A relação entre doenças virais e efeitos cognitivos já é bem estabelecida, o que torna possível pensar que o COVID-19 também é capaz de afetar o sistema nervoso. O sistema de saúde deve se preparar para enfrentar uma grande demanda relacionada a sequelas cognitivas, sendo necessário realizar reformas em sua estrutura. Conclusão: a continuação dos estudos acerca da síndrome pós-COVID-19 é essencial para a compreensão de uma condição que se mostra relacionada a tantos efeitos cognitivos.
Quality of water from springs in the administrative region of Brazlândia, located in the Descoberto River micro hydrographic basin, Federal District, Brazil
Authors: Cunha Marcos João da , Sá Lana CristinaLana Cristina Evangelista Ferreira , Gordinho Diego Leonardo Maximo , Silva Christian Lucas Américo da , Passaglia Fernanda Barros , Maldonade Iriani Rodrigues , Machado Eleuza Rodrigues
Published: June 2023

Water is essential for life and used for multiple purposes such as human consumption, agriculture and recreation. In this way, it must present physical-chemical characteristics adequate to the quality standards, without risk to human health. This study aimed to verify the water quality of the springs, in the municipality of the Regional city of Brazlândia, DF, Brazil, in the year 2021. The research was carried out in May and the water samples were collected in eleven points of springs and from Córrego de Brazlândia, in Veredinhas Park, from each sampling point, three liters of water were collected randomly and separately, for the investigation of enteroparasites, using the spontaneous sedimentation method. For the analysis of thermotolerant coliforms and Escherichia coli, three samples (100 ml) were collected and analyzed using the Colilert method. The organoleptic characteristics, pH, and presence of solid residues were verified in addition to observing the existence of the gallery forest. All areas analyzed had the presence of solid residues and most of the collection points had water with a cloudy appearance, unpleasant odor, and pH 6. All samples were positive for thermotolerant coliforms and presented at least one evolutionary form of intestinal parasite. Water sources in Brazlândia, DF, Brazil, are contaminated with potentially pathogenic microorganisms for humans. Thus, measures must be taken to minimize this situation, in addition to guidance and work with the community, to help in the recovery of these sources.
O uso de fitocosméticos para o tratamento de melasma: uma revisão de literatura
Authors: Silva Paula Maria da , Lima Salatiel Henrique Pereira de , Siqueira Lidiany da Paixão
Published: June 2023

O melasma é uma disfunção de hiperpigmentação, um aumento na produção de melanina que afeta a pele. Caracterizado pelo aparecimento de manchas escurecidas visíveis na maioria das vezes na face e em outras regiões fotoexpostas. Ele é geralmente causado pela exposição à radiação solar não sendo este o único fator, para a sua ocorrência. Embora ambos os sexos possam sofrer dessa discromia, ela acontece com mais frequência em mulheres, o que prejudica a aparência e o relacionamento delas com o meio em que vivem, já que a face é o cartão de visita que as pessoas têm, e é elemento importante para o desenvolvimento das relações interpessoais tanto no campo pessoal quanto no profissional, comprometendo a autoestima. O melasma não é um distúrbio totalmente esclarecido, uma vez que ainda não há uma cura, por isso, a partir de uma revisão de literatura este artigo pretende investigar as possíveis causas do melasma, identificando as características de cada um dos tipos, bem como compreender como o uso de ativos e extratos vegetais utilizados nas formulações de fitocosméticos pode contribuir no tratamento e quais têm o efeito mais favorável para reduzir as manchas, proporcionando uma melhor qualidade de vida. Visto que existe uma crescente pela busca do bem-estar e cuidados com a saúde contando com o avanço da ciência para as mais diversas condições clínicas e estéticas.
Atuação da Fisioterapia na incontinência urinária em gestantes: um estudo de revisão
Authors: Amorim Ane Cleise de Oliveira , Silva Leandro da , Ferro Thauan Narciso de Lima
Published: June 2023

Introdução: A incontinência urinária traz ao indivíduo importantes repercussões físicas e sociais na forma como se manifesta. Trata-se de uma perda involuntária de urina, e pode ser causada por diversos fatores e tem como sintomas a noctúria. Objetivo: Analisar através de um levantamento bibliográfico, a abordagem fisioterapêutica na incontinência urinária durante a gestação.  Metodologia: Trata-se de uma revisão integrativa de literatura, por meio da análise e estudo em artigos nacionais publicados em revistas indexadas, entre os anos de 2016 a 2022, tendo como referência as bases de dados: Banco de dados de evidências em fisioterapia (PEDro), PubMed, e Scientific Electronic Library Online (SciELO). Resultados: Os artigos selecionados mostram que, a incontinência não é considerada uma doença, mas uma condição que afeta muitas mulheres em seu período de gestação. Conclusão: A fisioterapia se mostra eficaz na prevenção e tratamento da incontinência urinária em gestantes, utilizando principalmente intervenções de treinamento da musculatura do assoalho pélvico.