bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical characteristics of COVID-19 in children compared with adults in Shandong, China
Authors: Du Wenjun , Yu Jinhong , Wang Hui , Zhang Xiaoguo , Zhang Shouwei , Li Qiang , Zhang Zhongfa
Published: March 2020

Aims & Background: The COVID-19 outbreak spread in China and is a threat to the world. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment.Methods: Retrospectively, two research centers’ case series of 67 consecutive hospitalized cases including 14 children cases with COVID-19 between 23 Jan 2020 to 15 Feb 2020 from Jinan and Rizhao were enrolled in this study. Epidemiological, clinical, laboratory, and radiological characteristics of children and adults were analyzed and compared.Results: Most cases in children were mild(21.4%) and conventional cases(78.6%), with mild clinical signs and symptoms, and all cases were of family clusters. Fever (35.7%) and dry cough(21.4%) were described as clinical manifestations in children cases. Dry cough and phlegm were not the most common symptoms in children compared with adults(p=0.03). In the early stages of the disease, lymphocyte counts did not significantly decline but neutrophils counts did in children compared with adults(p=0.00).There was an elevated level of LDH(p=0.01) and a lower level of CRP(p=0.00)and IL-6(p=0.01) in children compared with adults. There were 8 (57.1%)asymptomatic cases and 6 (42.9%)symptomatic cases among the 14 children cases. The age of asymptomatic patients was younger than that of symptomatic patients(p=0.03). Even among asymptomatic patients, 5(62.5%)cases had pneumonia including 3 (60%) cases with bilateral pneumonia, which was not different compared with that of asymptomatic cases(p=0.58, p=0.74).Conclusions: The clinical symptoms of children are mild, and the positive indicators of laboratory tests are rare, which may easily cause clinical misdiagnoses.
Reproductive Rights and Reproductive Choice of Yoruba Women in Southwestern Nigeria
Authors: Yusuff Olabisi Sherifat
Published: March 2020

While some social and health comes have improved significantly for women, significant gaps remain in the achievement of reproductive health rights and women’s choice. Women are still constrained by social, legal, religious and cultural impediments and family power dynamics from acting on their desires. The objective of this paper therefore is to examine the reproductive rights and choice of women entrepreneurs in South Western Nigeria Ibadan. The study adopts Rational Choice Theory and Gender role theory as theoretical guide. Quantitative and qualitative methods of data generation were employed. One Hundred and Twenty questionnaires were distributed to women with ten years marital experiences. The distribution of hundred and twenty questionnaires to women respondents was obtained through snowball method. Only In-depth interview conducted among 24women through purposive sampling techniques was employed to generate qualitative data. Quantitative information was analysed through simple percentage and frequency distribution. Findings from the study revealed that women’s reproductive decision-making processes are greatly influenced by their partners ranging from their age at first marriage, their access to family planning and abortion., which also given by the women as challenges on their reproductive rights in Sango, Ibadan.
Knowledge and Attitude Towards Intimate Partner Violence Among Ever-Married Women
Authors: Reyal Haizana Parween , Perera Koswaththage Manuja Niranshi , Guruge Galmangoda Najith Duminda
Published: March 2020

Effective approaches are needed to address high prevalence of intimate partner violence (IPV) against women in developing countries. Among them, addressing the attitudes of women justifying IPV is crucial. Yet, Sri Lankan studies so far have not adequately examined the community members’ knowledge and attitude toward IPV. Hence, this study aimed at i) describing knowledge and attitude towards IPV among women, ii) explore the association of socio-demographic variables with knowledge and attitude towards IPV, and iii) examine the association of knowledge and attitude with the abuse experiences. A cross-sectional survey was conducted with women (n = 600) aged 15-49 years from a selected health administrative area in Sri Lanka. Multistage cluster sampling was used to select participants and data collection was performed using an interviewer-administered questionnaire. Descriptive summaries, cross-tabulations and logistic regression analysis were performed to describe and explore the associations. Most respondents had poor knowledge (64.3%, n=386) on IPV with approximately half of them having attitudes generally justifying IPV (48.7%, n=292). Women with low levels of education and low household income were more likely to justify IPV. Further, employed women had good knowledge on IPV. Poor knowledge on IPV increased the risk of being abuse by 1.5 times and women who had justifying attitudes toward IPV had two times risk of being abuse. The necessity of interventions to be targeted on knowledge and attitudes and the contributory socio-demographic factors such as education, employment and income are emphasized.
Destek Eğitim Odalarında Görev Yapan Öğretmenlerin Gözüyle Destek Eğitim Odaları
Authors: YAZICIOĞLU Tansel
Published: March 2020

Destek eğitim odaları, kaynaştırma
eğitimi kapsamında, özel gereksinimli öğrencilerin kendilerine sunulan eğitim
hizmetinden en üst düzeyde yararlanmalarını sağlamak amacıyla, özel
araç-gereçler ve materyaller sağlanarak oluşturulan ortamlardır. Destek eğitim
odalarında öncelikle okulun öğretmenlerinden olmak üzere özel eğitim
öğretmenleri, sınıf öğretmeni ve alan öğretmenleri ile Rehberlik Araştırma
Merkezlerinde görevli özel eğitim öğretmenleri ya da diğer okul ve kurumlardaki
öğretmenler görevlendirilmektedir. Bu çalışmanın amacı destek eğitim odalarında
görev yapan öğretmenlerin destek eğitim odalarına ilişkin görüşlerini ortaya
koymaktır. Araştırmaya Ankara’nın Altındağ, Keçiören ve Yenimahalle
ilçelerindeki okulların destek eğitim odalarında görev yapan 18 öğretmen
katılmıştır. Nitel yöntemin kullanıldığı çalışmada, veriler yarı
yapılandırılmış görüşme sorularıyla toplanmış, tümevarım yöntemi kullanılarak
içerik analizi tekniği ile analiz edilmiştir. Araştırma bulguları destek eğitim
odalarının amacı doğrultusunda kullanılamadığını, ancak bu odaların gerekli ve
faydalı olduğunu göstermiştir.
Asesmen Multi Representasi Berbasis Keterampilan Abad Ke-21 pada Materi Gerak Lurus
Authors: Ellianawati Ellianawati , Mufiatunnikmah Siti , Setyaningsih Natalia Erna , Subali Bambang
Published: March 2020

This study aims to determine the quality figures of 21st century-based multi-representation assessments on linear motion material. Type of this research is Research & Development (R&D). Data were analyzed using an assessment validity test by an expert and empirical assessment quality test to obtain quality figures in the form of validity, reliability, level of difficulty, and discrimination power. The results of the preliminary field testing analysis showed 58.33% items were declared valid and 41.67% items were declared invalid. Test items have very high reliability with a value of 0.877. The proportion of the level of difficulty is not ideal, that is equal to 58.33% of questions categorized as difficult and 41.67% of questions categorized as sufficient. The discrimination power of the questions is 8.34% of the questions in a good category, 22.22% are sufficient, 58.33% are bad, and 11.11% are very bad. The result of main field testing, 69.44% items were declared valid and 30.56% items were declared invalid. Test items have high reliability with a value of 0.879. The proportion of the level of difficulty obtained in the main field testing is also not ideal, which is 56% of the difficult category and 44% of the sufficient category. The discrimination power consist of 32% good, 40% were sufficient, and 28% were poor.
Experimental study and flow analysis on a new design of water-retaining sluice gate
Authors: Tu Wenrong , Fang Shibiao , Sun Zhilin
Published: March 2020

As a water-retaining structure, the hydro-automatic flap gate (HFG) has advantages, such as easy operation, simple structure, attractive appearance, cheaper investment, and simple installation and maintenance compared to traditional gates. As such, the flow pattern analysis and flow rate analysis on this hydraulic structure have important engineering significance. In this paper, an experimental study was carried out for testing the water flow during the opening process of a bottom shaft driving flap gate. Three different opening velocities (once in 20 years, once in 50 years, once in 100 years) were selected for obtaining detailed characteristics. Then the space-time change laws of velocity and other hydraulic parameters of gate, gate pier and stilling pool were described. Moreover, the results of the flow regimes under conditions of once in 20 years, once in 50 years, once in 100 years were compared with each other. The findings and conclusions of this paper provide the basis for the project implementation in a sediment-laden river, and provide reference for other similar projects.
Rapid cultivation and stability of autotrophic nitrifying granular sludge
Authors: Zhang Linan , Long Bei , Cheng Yuanyuan , Wu Junfeng , Zhang Binchao , Zeng Yu , Huang Sinong , Zeng Mingjing
Published: March 2020

Autotrophic nitrifying granular sludge (ANGS) was cultivated by gradually decreasing the influent organics and adding exogenous nitrifying bacteria. Under the strategy, ANGS was domesticated within 36 days. Stability of the seed heterotrophic granules decreased significantly during conversion of organic wastewater to inorganic ammonia wastewater. Obvious granular breakage was observed during these days. However, the granular debris still had good settlement performance. With microbes gradually acclimated to the new environment, the debris provided a large number of carriers for the attached growth of the exogenous nitrifying bacteria, and they replaced the heterotrophic bacteria and became the dominant species. The domesticated ANGS showed good nitrification performance during the 37th to the 183rd day (ammonia nitrogen load between 0.28 and 0.29 kg/m3 · d). The removal rate of ammonia nitrogen was usually more than 95%, and nitrite accumulation rate was always larger than 50%. However, nitrification ability was gradually lost with the increase of the ammonia nitrogen load (0.3–0.64 kg/m3 · d) from the 184th day, and it almost approached the influent ammonia nitrogen at the 269th day. Interestingly, good structure stability of the ANGS was maintained during long-term operation, and the ANGS became smoother and denser at the end of the experiment.
Proposals for university promoting in QS rating based on the methods of statistical analysis
Authors: Mikryukov A. A. , Gasparian M. S. , Karpov D. S.
Published: March 2020

The purpose of the study. The purpose of the study is to develop scientifically based proposals to increase the university performance indicators in the international institutional rating QS to the required values, taking into account the presence of a combination of latent (hidden) factors, the degree of achievement of the set values of the basic indicators and, as a result, the university ranking level.

Materials and methods. To achieve this goal, methods of statistical analysis (correlation-regression and factor analysis) were used, which made it possible to identify the degree of influence of latent factors on basic indicators and the main indicator (rating functional). During the study, the following tasks were solved: identification of latent factors affecting the basic indicators of the university, an assessment of their significance and degree of influence on the basic indicators, as well as their grouping. Based on the results of the correlation - regression and factor analysis, measures are formulated to achieve the specified values of the QS University institutional rating indicators.

Results. An approach to solving the problem of providing conditions for achieving the required values of university performance indicators in the international institutional ranking QS using models developed based on the methods of correlation-regression and factor analysis is proposed. Estimates of the relationship of indicators and university ranking based on the methods of correlation and regression analysis are obtained. A comparative analysis of the results obtained at the universities of the reference group is made. The problem of identifying factors that influence the change in the values of indicators is solved; the degree of this influence is assessed. Based on the results obtained, reasonable proposals have been developed to achieve the required values of the basic indicators and the rating functional of the university.

Conclusion. The results obtained in the course of the study made it possible to justify the measures necessary to solve the problem of achieving the specified performance indicators of the university. Based on the correlation model, correlation dependencies between the rating functional and basic indicators are obtained. Interpretation of the results of factor analysis allowed us to identify a set of factors that have a significant impact on the basic indicators. It is shown that measures to achieve the specified indicators must be carried out taking into account the revealed correlation dependencies between factors and basic indicators, as well as the interpretation results of the developed factor model.
Nanoparticlized System: Promising Approach for the Management of Alzheimer’s Disease through Intranasal Delivery
Authors: Bahadur Shiv , Sachan Nidhi , Harwansh Ranjit K. , Deshmukh Rohitas
Published: March 2020

Alzheimer's disease (AD) is a neurodegenerative brain problem and responsible for causing dementia
in aged people. AD has become most common neurological disease in the elderly population worldwide and its
treatment remains still challengeable. Therefore, there is a need of an efficient drug delivery system which can
deliver the drug to the target site. Nasal drug delivery has been used since prehistoric times for the treatment of
neurological disorders like Alzheimer's disease (AD). For delivering drug to the brain, blood brain barrier (BBB)
is a major rate limiting factor for the drugs. The desired drug concentration could not be achieved through the
conventional drug delivery system. Thus, nanocarrier based drug delivery systems are promising for delivering
drug to brain. Nasal route is a most convenient for targeting drug to the brain. Several factors and mechanisms
need to be considered for an effective delivery of drug to the brain particularly AD. Various nanoparticlized systems
such as nanoparticles, liposomes, exosomes, phytosomes, nanoemulsion, nanosphere, etc. have been recognized
as an effective drug delivery system for the management of AD. These nanocarriers have been proven with
improved permeability as well as bioavailability of the anti-Alzheimer’s drugs. Some novel drug delivery systems
of anti-Alzheimer drugs are under investigation of different phase of clinical trials. Present article highlights on
the nanotechnology based intranasal drug delivery system for the treatment of Alzheimer’s disease. Furthermore,
consequences of AD, transportation mechanism, clinical updates and recent patents on nose to brain delivery for
AD have been discussed.
Acid-activated Sodium Bentonite and Kaolin Clay: Comparative Study by Physicochemical Properties
Authors: Kumar Awinash , Lingfa Pradip
Published: March 2020

Aim and Objective:

This paper aims to reveal the useful industrial aspects of kandite
and montmorillonite group of clays using as a catalyst after acid activation. A comparative study of
modified characteristics of clay samples has been explored based on industrial requirements.

Materials and Methods:

In this study sodium bentonite and kaolin clay have been focused. The
modified characteristics of clay samples are investigated by characterization methods of FT-IR,
XRD, SEM/EDAX, TGA and DSC before and after treated with 4M of Hydrochloric acid. Clay
samples were refluxed at 105ºC and calcined at 500ºC consecutively for 3 hours at room
temperature.

Results:

Maximum crystalline size 104.02 nm has been evaluated for acid-activated sodium
bentonite. Alkyl halides compounds have a strong band position for all samples and have more
extent on acid activation. The small numbers of manganese particles have been noticed in the acidactivated
samples. 14% of decrement and 61.02% of increment of aluminates have been found
respectively for acid-activated kaolin and acid-activated sodium bentonite.

Conclusion:

The novelty of this study is about sodium bentonite characterization and the results
show the prominent behaviour with structural, elemental, morphological, and thermal analysis.
Acid-activated kaolin sample has less effect in comparison with acid-activated sodium bentonite.
As the removal of the hydroxyl group of compounds has been reported through FT-IR and XRD
analysis also some other industries like ceramic and paper industries may have accepted these
types of modified minerals for special production with a simple process.
Structural And Computational Perspectives of Selectively Targeting Mutant Proteins
Authors: Coban Mathew A. , Fraga Sarah , Caulfield Thomas R.
Published: March 2020

:

Diseases are often caused by mutant proteins. Many drugs have limited effectiveness and/or toxic side effects because of a failure to selectively target the disease-causing mutant variant, rather than the functional wild type protein. Otherwise, the drugs may even target different proteins with similar structural features. Designing drugs that successfully target mutant proteins selectively represents a major challenge. Decades of cancer research have led to an abundance of potential therapeutic targets, often touted to be “master regulators”. For many of these proteins, there are no FDA-approved drugs available; for others, off-target effects result in dose-limiting toxicity. Cancer-related proteins are an excellent medium to carry the story of mutant-specific targeting, as the disease is both initiated and sustained by mutant proteins; furthermore, current chemotherapies generally fail at adequate selective distinction. This review discusses some of the challenges associated with selective targeting from a structural biology perspective, as well as some of the developments in algorithm approach and computational workflow that can be applied to address those issues. One of the most widely researched proteins in cancer biology is p53, a tumor suppressor. Here, p53 is discussed as a specific example of a challenging target, with contemporary drugs and methodologies used as examples of burgeoning successes. The oncogene KRAS, which has been described as “undruggable”, is another extensively investigated protein in cancer biology. This review also examines KRAS to exemplify progress made towards selective targeting of diseasecausing mutant proteins. Finally, possible future directions relevant to the topic are discussed.
Brain MR Image Classification for Glioma Tumor detection using Deep Convolutional Neural Network Features
Authors: Latif Ghazanfar , Iskandar D.N.F. Awang , Alghazo Jaafar , Butt M. Mohsin
Published: March 2020

Background:

Detection of brain tumor is a complicated task, which requires specialized
skills and interpretation techniques. Accurate brain tumor classification and segmentation from MR
images provide an essential choice for medical treatments. Different objects within an MR image
have similar size, shape, and density, which makes the tumor classification and segmentation even
more complex.

Objectives:

Classification of the brain MR images into tumorous and non-tumorous using deep features
and different classifiers to get higher accuracy.

Methods:

In this study, a novel four-step process is proposed; pre-processing for image enhancement
and compression, feature extraction using convolutional neural networks (CNN), classification
using the multilayer perceptron and finally, tumor segmentation using enhanced fuzzy cmeans
method.

Results:

The system is tested on 65 cases in four modalities consisting of 40,300 MR Images obtained
from the BRATS-2015 dataset. These include images of 26 Low-Grade Glioma (LGG) tumor
cases and 39 High-Grade Glioma (HGG) tumor cases. The proposed CNN feature-based classification
technique outperforms the existing methods by achieving an average accuracy of 98.77%
and a noticeable improvement in the segmentation results are measured.

Conclusion:

The proposed method for brain MR image classification to detect Glioma Tumor detection
can be adopted as it gives better results with high accuracies.
Inappropriate Medication Use and Cost Comparison Analysis of Proton Pump Inhibitors: Evidence from an Indian Tertiary Care Facility
Authors: Venkataraman Rajesh , Rashid Muhammed , Shrestha Heamant
Published: March 2020

Rationale and Objective:

Proton pump inhibitor (PPI) is one of the most widely prescribed
medicines and commonly used in gastric related disorders and there is a huge need to analyze
the irrational use of PPI in a country like India. The present study was designed to describe the
rational drug use and cost comparison analysis of PPI in a rural tertiary care hospital.

Methodology:

A prospective observational study was performed among 253 inpatients for a period
of 9 months after getting ethical approval. Those who received the PPIs for any of its indications
were included in the study without any gender or age restriction. US FDA guidelines were used to
analyse the appropriateness of the drug use and cost comparison analysis of the branded versus generic
PPIs was also performed.

Findings:

Among the 253 inpatients, the majority (62%) were male and the mean age was 46±19
years. Mean hospital stay and the number of drugs in prescription were found to be 4.0 ± 1days 4.39
±1.16 items, respectively. Pantoprazole (76%) was the most prescribed PPI even though the majority
(57%) of the patients treated outside the FDA approved indication. Drug interaction has been reported
in 14% and ADR in 9% of the population. The average cost of hospital stay estimated as
207.96+149.57 INR, and potential cost saving of INR 41582 was observed with generic replacement.

Conclusion:

The study inferred irrational drug use of PPI still prevalent, that too without considering the
economic impact of it on general populations. Healthcare practitioners should be aware and cautious
while prescribing the PPI to identify the actual need and to choose the most cost-effective alternative 1.
Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents
Authors: Laxmi Dandamudi Sri , Vardhini Suryadevara V. , Guttikonda Venkata R. , Rao Mandava V.B. , Pal Manojit
Published: March 2020

Background:

Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological
properties, including anticancer activities. Though these compounds are generally synthesized via the
heteroannulation processes involving acetylenic derivatives, some of them are complex.

Objective:

The study aimed to explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties
against cancer cell lines in vitro.

Methods:

We developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C
coupling followed by (ii) C-O bond-forming reactions in a single pot. The reactions were performed under ultrasound
irradiation in the presence of Pd/C as an inexpensive, stable and widely used catalyst. A range of 2-
substituted furo[3,2-b]pyridines were synthesized via coupling of 3-chloro-2-hydroxy pyridine with terminal
alkynes in the presence of 10% Pd/C-CuI-PPh3-Et3N in EtOH. The in vitro evaluation of all these compounds
was carried out against MDA-MB-231 and MCF-7 cell lines and subsequently against SIRT1.

Results:

The furo[3,2-b]pyridine derivative 3b showed encouraging growth inhibition of both MDAMB-231
and MCF-7 cell lines and inhibition of SIRT1. The compound 3b also showed apoptosis-inducing potential
when tested against MCF-7 cells.

Conclusion:

The Pd/C-Cu catalysis under ultrasound accomplished a one-pot and direct access to 2-substituted
furo[3,2-b]pyridine derivatives, some of which showed anticancer properties.
HUMANIZAÇÃO DO TRABALHO EM SAÚDE COMO OBJETIVO DA INTERVENÇÃO E PESQUISA NAS PRÁTICAS EDUCATIVAS
Authors: Fischborn Aline Fernanda , Viegas Moacir Fernando , Savegnago Jean de Fraga
Published: March 2020

O artigo parte de nossa preocupação, como pesquisadores das práticas educativas em educação e saúde, em construir práticas de pesquisa e intervenção no trabalho que resultem na produção de conhecimentos sobre as relações entre os saberes formalizados e a experiência dos trabalhadores, assim como em melhorias na realização de sua atividade. Nosso objetivo principal é apresentar uma reflexão abordando três questões a nosso ver essenciais à compreensão desse tema, quais sejam, o significado da intervenção nas relações de trabalho, as condições em que ocorrem e o que pensamos ser seus principais objetivos. Apoiamo-nos especialmente nos conceitos elaborados pela ergologia, tais como atividade, normalizações, renormalizações e écart, além do materialismo histórico e dialético e a teoria crítica, teorias que pensamos ser essenciais para a compreensão das práticas educativas em saúde realizadas nas relações de produção. Embora se trate de um artigo de caráter mais teórico, tem como pano de fundo pesquisas que temos desenvolvido em serviços de saúde. Assim, em alguns momentos traremos informações levantadas nesses estudos. Concluímos a exposição destacando algumas das contribuições metodológicas da ergologia para a compreensão e a intervenção nas práticas educativas nas relações de produção.
DA FORMAÇÃO SAPIENCIAL À TRANSFORMAÇÃO PROFÉTICA
Authors: Santos Luciano Costa
Published: March 2020

Com base no itinerário existencial do abade, pensador e escritor D. Timóteo Amoroso Anastácio, a partir das experiências inaugurais que contribuem para a sua formação humana e intelectual, busca-se articular neste artigo os principais núcleos conceptivos subjacentes a seu pensamento e obra. De tal reconstituição analítica destacam-se as vertentes sapiencial e profética de sua espiritualidade, cuja composição promove um fecundo diálogo entre a memória do eterno inscrita na tradição monástica e o projeto de emancipação da modernidade, gerando assim uma inaudita versão “transmoderna” do cristianismo, simultaneamente herdeira de milenar tradição sapiencial, atualizada com os movimentos históricos de libertação e enraizada na cultura local de matriz popular, configurando uma nova paideiaapta a responder aos principais desafios formativos postos na contemporaneidade.
INOVAÇÃO EM ESCOLAS RURAIS
Authors: Ghanem Elie
Published: March 2020

Este artigo aborda a origem da inovação educacional na atuação de uma ONG com escolas públicas de educação básica, em municípios de Pernambuco, Brasil. O objetivo da pesquisa foi detectar a presença ou não de alguns fatores na gênese da experiência investigada. Trata-se de um estudo de caso para o qual foi feito o exame de publicações e realizadas entrevistas semiestruturadas com dirigentes e agentes da ONG, assim como com docentes de escolas rurais e gestores de secretarias municipais de educação. Conclui que fatores salientes na geração da inovação são o tempo de experiência profissional de educadores(as), a estabilidade de sua equipe, o nível de qualificação e a atuação mobilizadora de líderes da ONG.
RECONHECER A EXPERIÊNCIA E A EXPERTISE DO DOENTE
Authors: Tourette-Turgis Catherine , Pereira-Paulo Lennize
Published: March 2020

O sucesso das estratégias terapêuticas no acompanhamento dos doentes crônicos tem como efeito o aumento da expectativa de vida e uma melhora da qualidade de suas vidas. Novos mecanismos, tal como a educação terapêutica do paciente, questionam o campo conceitual da formação de adultos. Esse artigo propõe considerar a experiência vivenciada da doença como uma oportunidade de aprendizagem e de desenvolvimento para o sujeito doente. O reconhecimento da experiência dos doentes deve abrir para uma validação das competências adquiridas pelos doentes, colocando em questão uma possível profissionalização. A Universidade dos Pacientes, um dispositivo universitário que diploma os doentes, ilustra em que medida o campo das inovações destinadas aos doentes crônicos ainda tem que se desenvolver para que os doentes possam tornar-se atores-chave na melhora da organização dos tratamentos.
Regenerative Therapy for Liver Cirrhosis Based on Intrahepatic Arterial Infusion of Autologous Subcutaneous Adipose Tissue-Derived Regenerative (Stem) Cells: Protocol for a Confirmatory Multicenter Uncontrolled Clinical Trial
Authors: Sakai Yoshio , Fukunishi Shinya , Takamura Masayuki , Inoue Oto , Takashima Shinichiro , Usui Soichiro , Seki Akihiro , Nasti Alessandro , Ho Tuyen Thuy Bich , Kawaguchi Kazunori , Asai Akira , Tsuchimoto Yusuke , Yamashita Taro , Yamashita Tatsuya , Mizukoshi Eishiro , Honda Masao , Imai Yasuhito , Yoshimura Kenichi , Murayama Toshinori , Wada Takashi , Harada Kenichi , Higuchi Kazuhide , Kaneko Shuichi
Published: March 2020

Background

Liver cirrhosis results from chronic hepatitis, and is characterized by advanced fibrosis due to long-term hepatic inflammation. Cirrhosis ultimately leads to manifestations of jaundice, ascites, and encephalopathy, and increases the risk of hepatocellular carcinoma. Once cirrhosis is established, resulting in hepatic failure, no effective treatment is available. Therefore, novel therapies to inhibit disease progression of cirrhosis are needed.

Objective

The objective of this investigator-initiated clinical trial is to assess the safety and efficacy of autologous adipose tissue-derived regenerative (stem) cell therapy delivered to the liver via the hepatic artery in patients with liver cirrhosis.

Methods

Through consultation with the Japan Pharmaceuticals and Medical Devices Agency, we designed a clinical trial to assess a therapy for liver cirrhosis based on autologous adipose tissue-derived regenerative (stem) cells, which are extracted using an adipose tissue dissociation device. The primary endpoints of the trial are the serum albumin concentration, prothrombin activity, harmful events, and device malfunction.

Results

Enrollment and registration were initiated in November 2017, and the follow-up period ended in November 2019. Data analysis and the clinical study report will be completed by the end of March 2020.

Conclusions

Completion of this clinical trial, including data analysis, will provide data on the safety and efficacy of this novel liver repair therapy based on autologous adipose tissue-derived regenerative (stem) cells using an adipose tissue dissociation device.

Trial Registration

UMIN Clinical Trials Registry UMIN000022601; https://tinyurl.com/w9uqw3q

International Registered Report Identifier (IRRID)

DERR1-10.2196/17904
Effectiveness of Foot Reflex Therapy in Postoperative Pain among Patients Subjected to Major Abdominal Surgery (Preprint)
Authors: Mohan Poongodi
Published: March 2020

BACKGROUND

Most of the patients experience post – operative pain and it is unavoidable. It is the duty of the nurses to ensure that patients' pain is assessed and managed effectively when they are at the hospital. Foot reflex therapy is one effective way the nurses can adopt to manage post-operative pain in patients.

OBJECTIVE

This study aims to prove the effectiveness of foot reflex therapy in post-operative pain in patients who are subjected to major abdominal surgery.

METHODS

This is a descriptive randomized control study that was conducted in the period month of Jan 2012 to Sep 2013 at Sri Ramachandra Medical College and Hospital among 360 patients who underwent major abdominal surgery. They were equally divided into two groups as control and study group and the results were analyzed statistically.

RESULTS

A majority of the patients in the study group showed a positive effect in the 4th and 5th post-operative day following foot reflex therapy.

CONCLUSIONS

The pre – existing pain and the post – operative pain is managed as collaboration along with nurses, patients, their care takers or families whenever appropriate in a multidisciplinary manner. Foot reflex therapy is one such alternative complementary therapy which the nurses can adopt to work in this accord.

CLINICALTRIAL

NOT REQUIRED
Form, Meaning and Function of Argot in French Rap Song: Sociolinguistics Study
Authors: Andree Aisyah Nadila , Ismail Nany , Darmayanti Nani
Published: March 2020

Music is one of the way to express emotions, opinions, and also criticism. The lyrics helps us to communicate, and spread its story. Argot in rap song is a sociolinguistic phenomenon that spreads in all languages, including French. The author conducted this study with the aim of knowing the formation of argot used, the meaning behind, and what correlation it has with situation in Marseille. The writer uses descriptive analysis method and theories that support this research are the theory of sociolinguistics and the process of forming argot Calvet (1994), as well as the theory of meaning Baylon and Mignot (1995). The conclusion contains apocope, apheresis, suffixation, and metonymy. The most uses type of formation is metonym. Metonym can deliver a figurative meaning to achieve dramatic effect, but still maintain its secretive nature. Argot has a relation with how singer express their situation and condition within their lyrics.
Function and Meaning of Penebel Society’s Prohibition
Authors: Ambara Ida Bagus Cahya , Kardana I Nyoman
Published: March 2020

This research is of two objectives, which are to examine the functions of Penebel Community’s expressions of prohibition and to reveal the meanings of the expressions. This research was conducted using qualitative research design. Data were collected by visiting the farmers’ habitats, observing their activities while recording using voice memo app in gadget, and conducting interviews to confirm the researchers’ understanding of the recorded messages. Results showed that the functions of Penebel inhabitants’ expressions of prohibition are informational and directives. Meanwhile the meanings of the expressions are both explicit and implied. The explicit meaning refers to the lexical meanings of the words that form it, which can be seen in the dictionary. The implied meaning is found based on the context of its use. Instead of containing illogical meanings and are considered to be out of date with the times, these phrases of prohibition needs to be preserved by providing their comprehensible meanings to the younger generation for they are a part of living culture and language.
The theological and political idea of modern Salafism by Anwar al-Jundi
Authors: Al-Janabi M. M.
Published: March 2020

The main idea of this study is to disclose the content of the theological and political ideas of modern Salafism of the ideology of the “Muslim Brotherhood” on the example of the work of Anwar al-Jundi (1917-2002). The fundamental question that Anwar al-Jundi has in all of his writings is to show how Muslims can preserve their Islamic identity. Hence the al-Jundi’s idea of the paramount importance of “optimizing Islamic rebirth and awakening”. An important place in understanding and maintaining Islamic identity is occupied by the theory of the “political conspiracy” of the West in relation to the Muslim world. This predetermines the political vision of Anwar al-Jundi, for whom the whole history of the relationship of the West with the Islamic world and Islam is links in a chain of overt and covert conspiracy. In the combined approach of Anwar al-Jundi, the theological vision and mentality prevail, reducing reality to a sample that substantiates the dogmas of religion and faith. As a result, a political vision of the theological type inevitably arises. It takes by Anwar al-Jundi the form of a methodology for criticizing the cultural and civilizational parameters of a political idea. His method in some of its aspects is not devoid of a scientific approach and contains deep criticisms, but remains within the framework of the same traditions of theological pedantry, which turns science, history and reflection into tools for serving religious dogmas.
Financial situation of the EAEU member states: deficits and surpluses, opportunities and risks
Authors: Fediakina Lora N.
Published: March 2020

The article defines the current level of stability and socio-economic development of the EAEU member states, and examines the factors constraining their economic growth. Public finances are considered: regional and consolidated budgets, budget deficits and sources of their coverage; state and state-guaranteed debts. The financial position of the countries participating in the Eurasian integration in relation to the outside world is analyzed, their deficits/surpluses and debts are revealed on the basis of balance of payments, foreign assets and liabilities.
The impact of cultivated land loss on China’s food security in the process of urbanization
Authors: Cheng Yining
Published: March 2020

This article examines the four stages of urbanization in China since the first days of the founding and discusses in detail about the relationship between changes in urbanization, the area of cultivated land and the production of grain products. The aim of this study is to clarify the impact of urbanization on cultivated land and grain production, as well as the problems caused by the fall in the amount of cultivated land. China is the country with the largest population, and whether China's food security can be guaranteed depends not only on China itself, but also on the world. Research method - data analysis, comparison. The scientific basis is the data of the National Bureau of statistics and the Land Bulletin of China.
Tourism industry in Russia and the EU: are there any consequences of multitiered national agenda?
Authors: Bogdashev Ilya V. , Apalkova Anna A. , Votchenko Elena S.
Published: March 2020

The aim of the research is to analyze the modern trends and today's development stage of tourism industries in Russia and the EU (Cyprus and the Czech Republic). The article touches a vital topic of contemporary relations among touristic sphere representatives (national and local entrepreneurs), society (consumers), and governmental support (national and local authorities) through the prism of their relations. The authors consider fundamental macro-economic indicators of the tourism industry as an object of the research, whereas mathematical methods of forecasting in tourism studies are as a subject of the research. Besides, the authors underline the main directions of entrepreneurship support as a part of being a successful start-up, in our case, in the touristic industry. Furthermore, it is worth noting the characteristics of the tourism market and the peculiarities of its regulation. In the end, the collaborators have concluded by analyzing the fact that the government regulation of tourism is an effective means of stimulating investment activity, improving the quality of services provided, and solving social problems in terms of the real health of the nation. However, it is crucial to bear in mind that the main directions of state policy should be the stability and competitiveness of the tourist complex.
Methodical approach to assessing the volume of youth labour migration in the states of the Eurasian Economic Union
Authors: Veselko Alena A.
Published: March 2020

Labour migration plays an integral role in the socio-economic development of any country; it affects both the structure and the size, the social and economic spheres of society. Therefore, it is necessary to monitor the migration process, because, in the future, it can have a positive impact on the economic growth of the country. The article proposes a model for macro-economic assessment of the volume of youth labor migration in the states of the Eurasian Economic Union (EAEU). The model is based on the ideas of labor migration in the form of a random Markov process with discrete states and continuous time. The chain states are interpreted as the labour market of the youth of the respective EAEU states, and the transition rates reflect the attractiveness of these markets for young people from different states. This made it possible to take into account the inherent uncertainty and inertia in the process of youth migration.
Book Review of “Exploring the Future of Russia's Economy and Markets: Towards Sustainable Economic Development” (ed. by Bruno S. Sergi. Emerald Publishing Limited, 2019. 288 p.)
Authors: Turgel Irina D.
Published: March 2020

The monograph under review is devoted to a multilateral analysis of the Russian economy and the prospects for its development in the modern world. The book provides an in-depth analysis of the financial and industrial sectors of the economy, industrial policy, and opportunities for an innovative and green economy in Russia. Impacts of sanctions, the prospects for the development of new industries based on modern technologies in Russia are discussed.
Resenha
Authors: DA COSTA JONATHAN KAEFER GOMES
Published: March 2020

Resenha do livro "A literatura como arquivo da ditadura brasileira" escrito pela professora Eurídice Figueiredo. Livro publicado no Rio de Janeiro pela editora 7 letras no ano de 2017.
Os diversos “Pedros” que habitam as cidades: violência, cotidiano e experiência urbana em Contos de Pedro e Passageiro do fim do dia, de Rubens Figueiredo
Authors: Montebelo Barcelos Carolina
Published: March 2020

Pedro é nome de personagens em diversas obras da literatura brasileira, como Capitães de Areia, de Jorge Amado, e Lira Paulistana, de Mário de Andrade. Em comum, esses Pedros têm a origem em uma classe social pobre e trabalhadora. O professor, tradutor e escritor Rubens Figueiredo também dedicou boa parte de sua obra ficcional à retratação do cotidiano das vítimas da injustiça e exclusão social, principalmente nas áreas urbanas e suas periferias. Portanto, o objetivo deste artigo é examinar os modos pelos quais a violência, seja ela de caráter físico ou oriunda da desigualdade social, é representada em Contos de Pedro, de 2006, e Passageiro do fim do dia, publicado em 2010. Críticos e teóricos como Beatriz Resende e Karl Erik Schollhammer veem uma heterogeneidade na literatura brasileira contemporânea e, dentre suas diversas características, a urgência em se relacionar com a realidade histórica pode ser percebida nos contos e romance analisados aqui, haja vista a necessidade que Rubens Figueiredo mostra ao abordar a realidade social e urbana. Seja através da perspectiva do Pedro de Passageiro do fim do dia, ou do olhar onisciente dos narradores dos Contos de Pedro, estamos diante de jovens e adultos, mulheres e homens, cuja exclusão social pode ser percebida por meio de temas como solidão, educação e escola, violência e desilusão. É através do cotidiano de vida e trabalho precários dos Pedros dos contos, ou da perspectiva experienciada por Pedro no romance, que o autor, tal como Chico Buarque na música Pedro Pedreiro, denuncia a opressão da classe trabalhadora brasileira.
Representações da violência na literatura: apontamentos para uma possível apresentação
Authors: Braem Eloísa Porto C. Allevato , Oliveira Paulo S.
Published: March 2020

A violência tem se apresentado como um tema recorrente em pesquisas de estudiosos das literaturas, até porque obras de imaginação sempre se mostraram como um locus privilegiado para o estudo de diferentes temas ligados ao humano e às suas sociedades. Em virtude disso, o dossiê “Representações da Violência na Literatura” reúne e divulga pesquisas acadêmicas sobre diferentes modalidades da violência refletidas em obras literárias de variadas épocas e nacionalidades, a partir de diversificados enfoques teórico-metodológicos. São cotejadas obras desde as tebanas Édipo Rei e Antígona, de Sófocles, até Vidas secas, de Graciliano Ramos, e Infância dos mortos, de José Louzeiro, dentre muitas outras. Servem de ancoragem para os estudos obras como as de Walter Benjamin (2011), Jacques Derrida (1997), Michel Foucault (1987, 2013), Freud (2010), Friedrich Nietzsche (1998).
Permanence and asymptotic behaviors of stochastic competitive Lotka-Volterra system with Markov switching and Lévy noise
Authors: Wang Sheng , Hu Guixin , Wang Linshan
Published: March 2020

This paper concerns the dynamics of a stochastic competitive Lotka-Volterra
system with Markov switching and L?vy noise. The results show that
stochastic permanence and extinction are characterized by two parameters B1
and B2: if B1B2 ? 0, then the system is either stochastically permanent or
extinctive. That is, it is extinctive if and only if B1 < 0 and B2 < 0;
otherwise, it is stochastically permanent. Some existing results are
included as special cases.
The m-extension of Fibonacci and Lucas p-difference sequences
Authors: Köme Cahit , Yazlik Yasin
Published: March 2020

In this paper we define the m-extension of Fibonacci and Lucas p-difference
sequences by using the m-extension of Fibonacci and Lucas p-numbers. We
investigate some properties of our new sequences and introduce some
relations between the m-extension of Fibonacci and Lucas p-difference
sequences and the m-extension of Fibonacci and Lucas p-numbers. Moreover,
we present the sums and generating function of the m-extension of Fibonacci
and Lucas p-difference sequences. Finally, we study the m-extension of
Fibonacci p-difference Newton polynomial interpolation.
Centralizing b-generalized derivations on multilinear polynomials
Authors: Tiwari S.K. , Prajapati B.
Published: March 2020

Let R be a prime ring of characteristic different from 2 and F a b-generalized
derivation on R. Let U be Utumi quotient ring of R with extended centroid C
and f (x1,..., xn) be a multilinear polynomial over C which is not
central valued on R. Suppose that d is a non zero derivation on R such that
d([F(f(r)), f(r)]) ? C for all r = (r1,..., rn) ? Rn, then one of the
following holds: (1) there exist a ? U, ? ? C such that F(x) = ax + ?x + xa
for all x ? R and f (x1,..., xn)2 is central valued on R, (2) there
exists ? ? C such that F(x) = ?x for all x ? R.
Generalized inequalities of warped product submanifolds of nearly Kenmotsu f-manifolds
Authors: Balkan Yavuz , Alkhaldi Ali , Siddiqui Aliya , Ali Akram
Published: March 2020

In the present paper, we establish two general sharp inequalities for the
squared norm of second fundamental form for mixed totally geodesic warped
product pseudo-slant submanifolds of the form M? xf M? and M? xf M?, in a
nearly Kenmotsu f-manifold M, which include the squared norm of the warping
function and slant angle. Also, equality cases are verified. We proved that
some previous results are trivial from our results. Moreover, we generalized
the inequality theorems [3] and [26] from our derived results.
Monotone relations in Hadamard spaces
Authors: Moslemipour Ali , Roohi Mehdi , Mardanbeigi Mohammad , Azhini Mahdi
Published: March 2020

In this paper, the notion of W-property for subsets of X x X? is introduced
and investigated, where X is an Hadamard space and X? is its linear dual
space. It is shown that an Hadamard space X is flat if and only if X x X?
has W-property. Moreover, the notion of monotone relation from an Hadamard
space to its linear dual space is introduced. A characterization result for
monotone relations with W-property (and hence in flat Hadamard spaces) is
given. Finally, a type of Debrunner-Flor Lemma concerning extension of
monotone relations in Hadamard spaces is proved.