bluuebunny/crossref_metadata_2025 huggingface dataset:
Geospatial Assessments of DNA Adducts in the Human Stomach: A Model of Field Cancerization
Authors: Iwashita Yuji , Ohnishi Ippei , Matsushita Yuto , Ohtsuka Shunsuke , Yamashita Takashi , Inaba Keisuke , Fukazawa Atsuko , Ochiai Hideto , Matsumoto Keigo , Kurono Nobuhito , Matsushima Yoshitaka , Mori Hiroki , Suzuki Shioto , Suzuki Shohachi , Tanioka Fumihiko , Sugimura Haruhiko
Published: July 2021

Background: Field cancerization is a popular concept regarding where cancer cells arise in a plane, such as the opened-up gastrointestinal mucosa. The geospatial distribution of DNA adducts, some of which are believed to initiate mutation, may be a clue to understanding the landscape of the preferred occurrence of gastric cancer in the human stomach, such that the occurrence is much more frequent in the lesser curvature than in the greater curvature. Methods: Seven DNA adducts, C5-methyl-2′-deoxycytidine, 2′-deoxyinosine, C5-hydroxymethyl-2′-deoxycytidine, N6-methyl-2′-deoxyadenosine, 1,N6-etheno-2′-deoxyadenosine, N6-hydroxymethyl-2′-deoxyadenosine, and C8-oxo-2′-deoxyguanosine, from different points and zones of the human stomach were semi quantitatively measured by liquid chromatography/tandem mass spectrometry. The differences in the quantity of these DNA adducts from the lesser and greater curvature, the upper, middle and lower third zones, the anterior and posterior wall of the stomach, and the mucosae distant from and near the tumor were compared to determine whether the location preference of cancer in the stomach could be explained by the distribution of these DNA adducts. Comparisons were conducted considering the tumor locations and operation methods. Conclusions: Regarding the DNA adducts investigated, significant differences in quantities and locations in the whole stomach were not noted; thus, these DNA adducts do not explain the preferential occurrence of cancer in particular locations of the human stomach.
The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma
Authors: Zhang Chunye , Yang Ming
Published: July 2021

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, followed by cholangiocarcinoma (CCA). HCC is the third most common cause of cancer death worldwide, and its incidence is rising, associated with an increased prevalence of obesity and nonalcoholic fatty liver disease (NAFLD). However, current treatment options are limited. Genetic factors and epigenetic factors, influenced by age and environment, significantly impact the initiation and progression of NAFLD-related HCC. In addition, both transcriptional factors and post-transcriptional modification are critically important for the development of HCC in the fatty liver under inflammatory and fibrotic conditions. The early diagnosis of liver cancer predicts curative treatment and longer survival. However, clinical HCC cases are commonly found in a very late stage due to the asymptomatic nature of the early stage of NAFLD-related HCC. The development of diagnostic methods and novel biomarkers, as well as the combined evaluation algorithm and artificial intelligence, support the early and precise diagnosis of NAFLD-related HCC, and timely monitoring during its progression. Treatment options for HCC and NAFLD-related HCC include immunotherapy, CAR T cell therapy, peptide treatment, bariatric surgery, anti-fibrotic treatment, and so on. Overall, the incidence of NAFLD-related HCC is increasing, and a better understanding of the underlying mechanism implicated in the progression of NAFLD-related HCC is essential for improving treatment and prognosis.
Docetaxel Skin Exposure and Micronucleation Contributes to Skin Toxicity Caused by CPC634
Authors: Atrafi Florence , van Eerden Ruben A. G. , Koolen Stijn L. W. , de Bruijn Peter , Rijcken Cristianne J. F. , Hanssen Rob , Eskens Ferry A. L. M. , Lolkema Martijn P. , Oomen-de Hoop Esther , Damman Jeffrey , Mathijssen Ron H. J.
Published: July 2021

Docetaxel entrapped nanoparticle CPC634 is associated with dose-related skin toxicity that resembles conventional docetaxel (Cd)-related skin toxicity. This study compared the cutaneous pharmacokinetics and pharmacodynamics of docetaxel and CPC634. In this randomised cross-over study, patients with solid tumours received one cycle of CPC634 and Cd (both at 75 mg/m2). Skin biopsies were taken at baseline and at day 8 of both cycles. Released and total docetaxel (released docetaxel plus entrapped docetaxel) concentrations and histopathological changes in the skin biopsies were evaluated. Twenty patients underwent paired skin biopsies for pharmacokinetic analysis and 10 patients had biopsies available for histopathological assessment. The total skin docetaxel concentration was 369% (95%CI: 229% to 569%, p < 0.001) higher after CPC634 administration compared to Cd while the released docetaxel concentrations were not statistically different (95%CI: −9% to 63%, p = 0.169). The CPC634 released docetaxel concentration in the skin was positively correlated with plasma concentrations (Pearson’s correlation 0.48, p = 0.03). Histopathological examination revealed increased apoptosis, mitotic cells with nuclear atypia, and micronucleation with an enhanced Ki-67 index for both compounds. In conclusion, both CPC634 and Cd treatment result in docetaxel exposure in the skin causing cutaneous anti-mitotic effects such as micronucleation, which could induce an inflammatory reaction leading to skin toxicity.
Current Situation of Proton Therapy for Hodgkin Lymphoma: From Expectations to Evidence
Authors: Loap Pierre , Mirandola Alfredo , De Marzi Ludovic , Dendale Remi , Iannalfi Alberto , Vitolo Viviana , Barcellini Amelia , Filippi Andrea Riccardo , Jereczek-Fossa Barbara Alicja , Kirova Youlia , Orlandi Ester
Published: July 2021

Consolidative radiation therapy (RT) is of prime importance for early-stage Hodgkin lymphoma (HL) management since it significantly increases progression-free survival (PFS). Nevertheless, first-generation techniques, relying on large irradiation fields, delivered significant radiation doses to critical organs-at-risk (OARs, such as the heart, to the lung or the breasts) when treating mediastinal HL; consequently, secondary cancers, and cardiac and lung toxicity were substantially increased. Fortunately, HL RT has drastically evolved and, nowadays, state-of-the-art RT techniques efficiently spare critical organs-at-risks without altering local control or overall survival. Recently, proton therapy has been evaluated for mediastinal HL treatment, due to its possibility to significantly reduce integral dose to OARs, which is expected to limit second neoplasm risk and reduce late toxicity. Nevertheless, clinical experience for this recent technique is still limited worldwide. Based on current literature, this critical review aims to examine the current practice of proton therapy for mediastinal HL irradiation.
Controlled Synthesis of CuS and Cu9S5 and Their Application in the Photocatalytic Mineralization of Tetracycline
Authors: Ravele Murendeni P. , Oyewo Opeyemi A. , Onwudiwe Damian C.
Published: July 2021

Pure-phase Cu2−xS (x = 1, 0.2) nanoparticles have been synthesized by the thermal decomposition of copper(II) dithiocarbamate as a single-source precursor in oleylamine as a capping agent. The compositions of the Cu2−xS nanocrystals varied from CuS (covellite) through the mixture of phases (CuS and Cu7.2S4) to Cu9S5 (digenite) by simply varying the temperature of synthesis. The crystallinity and morphology of the copper sulfides were studied using X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM), which showed pure phases at low (120 °C) and high (220 °C) temperatures and a mixture of phases at intermediate temperatures (150 and 180 °C). Covellite was of a spherical morphology, while digenite was rod shaped. The optical properties of these nanocrystals were characterized by UV−vis–NIR and photoluminescence spectroscopies. Both samples had very similar absorption spectra but distinguishable fluorescence properties and exhibited a blue shift in their band gap energies compared to bulk Cu2−xS. The pure phases were used as catalysts for the photocatalytic degradation of tetracycline (TC) under visible-light irradiation. The results demonstrated that the photocatalytic activity of the digenite phase exhibited higher catalytic degradation of 98.5% compared to the covellite phase, which showed 88% degradation within the 120 min reaction time using 80 mg of the catalysts. The higher degradation efficiency achieved with the digenite phase was attributed to its higher absorption of the visible light compared to covellite.
Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes
Authors: Masini Matilde , Suleiman Mara , Novelli Michela , Marselli Lorella , Marchetti Piero , De Tata Vincenzo
Published: July 2021

Mast cells are highly differentiated, widely distributed cells of the innate immune system, that are currently considered as key regulators of both innate and adaptive immunity. Mast cells play a key role in health and survival mechanisms, especially as sentinel cells that can stimulate protective immune responses. On the other hand, it has been shown that mast cells are involved in the pathogenesis of several diseases, and recently a possible pathogenetic role of mast cells in diabetes has been proposed. In this review we summarize the evidence on the increased presence of mast cells in the pancreas of subjects with type 1 diabetes, which is due to the autoimmune destruction of insulin secreting beta cells, and discuss the differences with type 2 diabetes, the other major form of diabetes. In addition, we describe some of the pathophysiological mechanisms through which mast cells might exert their actions, which could be targeted to potentially protect the beta cells in autoimmune diabetes.
The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide
Authors: Aichhorn Lukas , Küng Erik , Habrina Lisa , Werther Tobias , Berger Angelika , Urlesberger Berndt , Schwaberger Bernhard
Published: July 2021

Lung ultrasound makes use of artifacts generated by the ratio of air and fluid in the lung. Recently, an enormous increase of research regarding lung ultrasound emerged, especially in intensive care units. The use of lung ultrasound on the neonatal intensive care unit enables the clinician to gain knowledge about the respiratory condition of the patients, make quick decisions, and reduces exposure to ionizing radiation. In this narrative review, the possibilities of lung ultrasound for the stabilization and resuscitation of the neonate using the ABCDE algorithm will be discussed.
Parenting Styles, Coparenting, and Early Child Adjustment in Separated Families with Child Physical Custody Processes Ongoing in Family Court
Authors: Pires Mónica , Martins Mariana
Published: July 2021

Coparenting conflict and triangulation after separation or divorce are associated with poorer child adjustment when parenting gatekeeping and conflict occur. Fewer studies reported psychosocial adjustment of children under three. We explored the effects of authoritarian and permissive parenting styles and negative coparenting on child adjustment in a purpose sample of 207 Portuguese newly separated/divorced parents (50.2% mothers/49.8% fathers) with sole or joint (49.8%/50.2%) physical custody processes ongoing in court. Parents filled out the Parenting Styles Questionnaire—Parents’ report, the Coparenting Questionnaire, and the Strengths and Difficulties Questionnaire. Parenting and coparenting moderations path analysis to predict child adjustment were tested for two groups (2/3-year-old child/>3-year-old-child) and showed a good fit, followed by multigroup path analysis with similarities. Findings suggest harsh parenting and interparental conflict and triangulation as predictors for poor early child adjustment. The ongoing custody process could contribute to increased interparental conflict. The families’ unique functioning, parenting, and conflict should be considered in young children custody decisions made in a particularly stressful period when the parental responsibilities’ process is still ongoing and conflict may increase to serve the best interest of the child and promote healthy development. Future directions and practical implications are discussed.
Pulmonary Vein Stenosis—Evolving Surgical Management of a Challenging Disease
Authors: Feins Eric N. , Callahan Ryan , Baird Christopher W.
Published: July 2021

Pulmonary vein stenosis (PVS) is an extremely challenging clinical problem in congenital heart disease. It has traditionally required multimodal therapy given its complex underlying pathophysiology. As with other modalities, surgical therapy has undergone tremendous evolution since the 1950s. These evolving strategies have been based upon an improved understanding of the substrates that cause PVS and recurrent vein obstruction. More recent anatomic-based surgical strategies have focused on the pulmonary vein course, and how adjacent mediastinal structures can create a fulcrum effect on the pulmonary veins as they pass from the lung parenchyma to the left atrium. The consequent angulation of pulmonary veins creates altered wall shear stress and likely serves as a nidus for recurrent PVS. Encouraging early results suggest that eliminating pulmonary vein angulation and shortening/straightening the pulmonary vein course may prove effective in surgically managing PVS.
Independent Risk Factors for RBC Transfusion in Children Undergoing Surgery. Analysis of 14,248 Cases at a German University Hospital
Authors: Piekarski Florian , Neef Vanessa , Meybohm Patrick , Rolle Udo , Schneider Wilfried , Zacharowski Kai , Schmitt Elke
Published: July 2021

Background: paediatric patients are vulnerable to blood loss and even a small loss of blood can be associated with severe shock. In emergency situations, a red blood cell (RBC) transfusion may become unavoidable, although it is associated with various risks. The aim of this trial was to identify independent risk factors for perioperative RBC transfusion in children undergoing surgery. Methods: to identify independent risk factors for perioperative RBC transfusion in children undergoing surgery and to access RBC transfusion rates and in-hospital outcomes (e.g., length of stay, mortality, and typical postoperative complication rates), a monocentric, retrospective, and observational study was conducted. Descriptive, univariate, and multivariate analyses were performed. Results: between 1 January 2010 and 31 December 2019, data from n = 14,248 cases were identified at the centre. Analysis revealed an RBC transfusion rate of 10.1% (n = 1439) in the entire cohort. The independent predictors of RBC transfusion were the presence of preoperative anaemia (p < 0.001; OR = 15.10 with preoperative anaemia and OR = 2.40 without preoperative anaemia), younger age (p < 0.001; ORs between 0.14 and 0.28 for children older than 0 years), female gender (p = 0.036; OR = 1.19 compared to male gender), certain types of surgery (e.g., neuro surgery (p < 0.001; OR = 10.14), vascular surgery (p < 0.001; OR = 9.93), cardiac surgery (p < 0.001; OR = 4.79), gynaecology (p = 0.014; OR = 3.64), visceral surgery (p < 0.001; OR = 2.48), and the presence of postoperative complications (e.g., sepsis (p < 0.001; OR = 10.16), respiratory dysfunction (p < 0.001; OR = 7.56), cardiovascular dysfunction (p < 0.001; OR = 4.68), neurological dysfunction (p = 0.029; OR = 1.77), and renal dysfunction (p < 0.001; OR = 16.17)). Conclusion: preoperative anaemia, younger age, female gender, certain types of surgery, and postoperative complications are independent predictors for RBC transfusion in children undergoing surgery. Future prospective studies are urgently required to identify, in detail, the potential risk factors and impact of RBC transfusion in children.
A Robust Observer—Based Adaptive Control of Second—Order Systems with Input Saturation via Dead-Zone Lyapunov Functions
Authors: Rincón Alejandro , Restrepo Gloria M. , Hoyos Fredy E.
Published: July 2021

In this study, a novel robust observer-based adaptive controller was formulated for systems represented by second-order input–output dynamics with unknown second state, and it was applied to concentration tracking in a chemical reactor. By using dead-zone Lyapunov functions and adaptive backstepping method, an improved control law was derived, exhibiting faster response to changes in the output tracking error while avoiding input chattering and providing robustness to uncertain model terms. Moreover, a state observer was formulated for estimating the unknown state. The main contributions with respect to closely related designs are (i) the control law, the update law and the observer equations involve no discontinuous signals; (ii) it is guaranteed that the developed controller leads to the convergence of the tracking error to a compact set whose width is user-defined, and it does not depend on upper bounds of model terms, state variables or disturbances; and (iii) the control law exhibits a fast response to changes in the tracking error, whereas the control effort can be reduced through the controller parameters. Finally, the effectiveness of the developed controller is illustrated by the simulation of concentration tracking in a stirred chemical reactor.
Charge Order and Suppression of Superconductivity in HgBa2CuO4+d at High Pressures
Authors: Izquierdo Manuel , Freitas Daniele C. , Colson Dorothée , Garbarino Gastón , Forget Anne , Raffy Helène , Itié Jean-Paul , Ravy Sylvain , Fertey Pierre , Núñez-Regueiro Manuel
Published: July 2021

New insight into the superconducting properties of HgBa2CuO4 (Hg-1201) cuprates is provided by combined measurements of electrical resistivity and single crystal X-ray diffraction under pressure. The changes induced by increasing pressure up to 20 GPa in optimally doped single crystals were investigated. The resistivity measurements as a function of temperature show a metallic behavior up to ~10 GPa that gradually passes into an insulating state, typical of charge ordering, which totally suppresses superconductivity above 13 GPa. The changes in resistivity are accompanied by the apparition of sharp Bragg peaks in the X-ray diffraction patterns, indicating that the charge ordering is accompanied by a 3D oxygen ordering. Considering that pressure induces a charge transfer of about 0.02 at 10 GPa, our results are the first observation of charge order competing with superconductivity developed in the overdoped region of the phase diagram of a Hg-based cuprate.
Cross-Investigation on Copper Nitroprusside: Combining XRD and XAS for In-Depth Structural Insights
Authors: Mullaliu Angelo , Aquilanti Giuliana , Plaisier Jasper Rikkert , Giorgetti Marco
Published: July 2021

The emerging energy demand and need to develop sustainable energy storage systems have drawn extensive attention to fundamental and applied research. Anion redox processes were proposed in cathodic materials in addition to traditional transition metal redox to boost the specific capacity and the electrochemical performance. Alternatively, copper nitroprusside (CuNP) features an electroactive nitrosyl ligand alongside the two structural metals (Fe, Cu), representing an alternative to anion redox in layered oxides. Here, a deep structural investigation is carried out on CuNP by complementing the long-range order sensitivity of X-ray diffraction (XRD) and the local atomic probe of X-ray absorption (XAS). Two different CuNP materials are studied, the hydrated and dehydrated forms. A new phase for hydrated CuNP not reported in the literature is solved, and Rietveld refined. The XAS spectra of the two materials at the Cu and Fe K-edges show a similar yet different atomic environment. The extended XAS spectra (EXAFS) analysis is accomplished by considering three- and four-body terms due to the high collinearity of the atomic chains and gives accurate insight into the first-, second-, and third-shell interatomic distances. Both materials are mounted in Li-ion and Na-ion cells to explore the link between structure and electrochemical performance. As revealed by the charge/discharge cycles, the cyclability in Na-ion cells is negatively affected by interstitial water. The similarity in the local environment and the electrochemical differences suggest a long-range structural dependence on the electrochemical performance.
Crystal Structure and Electrical Characteristics of (0.965)(Li0.03(Na0.5K0.5)0.97)(Nb1−xSbx)O3−0.035(Bi0.5Na0.5)0.9(Sr)0.1ZrO3 Ceramics Doped with CuO, B2O3, and ZnO
Authors: Yoo Juhyun , Kang Sujin
Published: July 2021

Recently, the need has arisen to enhance the piezoelectric properties and temperature stability of (Na,K)NbO3 system ceramics. The (0.965)(Li0.03(Na0.5K0.5)0.97)(Nb1−xSbx)O3−0.035 (Bi0.5Na0.5)0.9(Sr)0.1ZrO3 ceramics were newly manufactured using the sintering aids of CuO, B2O3, and ZnO as a function of antimony substitution, and the their crystal structure and electrical characteristics were analyzed. The grain size was apparently refined as the amount of antimony increased. The dielectric constant was enhanced and Curie temperature was decreased due to the content of the antimony substitution. The x = 0.07 sample sintered at 1060 °C presented the best electrical characteristics, which were bulk density = 4.488 g/cm3, piezoelectric constant d33 = 330 pC/N, electromechanical coupling factor kp = 0.427, mechanical coupling factor Qm = 61, and dielectric constant εr = 2521. We believe that the x = 0.07 sample is the best material for piezoelectric speakers.
Microstructure Evaluation Study of Al5083 Alloy Using EBSD Technique after Processing with Different ECAP Processes and Temperatures
Authors: Baig Muneer , Seikh Asiful H. , Rehman Ateekh Ur , Mohammed Jabair A. , Hashmi Faraz Hussain , Ragab Sameh Mohamed
Published: July 2021

The temperature effects on the microstructural evolution of a coarse-grained Al5083 alloy during equal channel angular pressing (ECAP), were studied at ambient and high temperatures. The microstructural evaluation was done using an EBSD (electron backscattering diffraction) process. The grain refinement occurred as the number of passes increased, which had a positive effect on its strength. Additionally, increasing the pressing temperature leads to a decrease in the new grain’s formation and an increase in the normal grain size in the third pass. This can be ascribed to the unwinding of strain similarity between the grains because of the continuous activity of dynamic recuperation and the grain limit sliding occurring at a higher temperature. The attainment of grain refinement is examined exhaustively in this study.
The Relationship between Compressive Strength and Pore Structure of the High Water Grouting Material
Authors: Han Youmin , Xia Junwu , Yu Linli , Su Qiong , Chen Xiaomiao
Published: July 2021

To elucidate the relationship between compressive strength and pore structure of the high water grouting material with different water-binder ratios and CaO contents, the compressive strength was tested while pore structure including pore characteristic parameters and pore diameter distribution were investigated by BET, MIP, and 3D-XRM. Moreover, the evolution of hydration products was observed by TGA and SEM, illustrating the reactive mechanism of the material. Furthermore, the grey correlation coefficients between compressive strength and pore structure parameters were illustrated according to the grey correlation theory. The results show that CaO content in lime is proportional to the compressive strength with the water-binder ratio of 1.0 or 1.5, while the inverse trend appears with the water-binder ratio of 2.0. The high water grouting material belongs to the macropore material with the pores mainly within 100 nm to 2 μm. Its hydration products contain ettringite crystals, aluminum gels, and C-S-H gels. The productions of the hydration products are positively correlated with its compressive strength. In addition, the compressive strength of the high water grouting material is closely related to the pore characteristic parameters and the pore size distribution, especially the porosity, the most probable pore diameter, and the pore volumes within 100~500 nm and 10~100 nm.
The Natural History of Uterine Venous Plexus Thrombosis
Authors: Amin Tejal N. , Cohen Hannah , Wong Michael , Pointer Sara-Louise , Aslam Naaila , Jurkovic Davor
Published: July 2021

The management of incidental or unusual site venous thrombosis (VT) is challenging and is often extrapolated from studies on symptomatic deep venous thrombosis (DVT). There is a tendency to treat with anticoagulation, due to the theoretical risk of propagation and embolism; however, this is not without risk. Furthermore, there is little guidance on how to monitor incidental VT. The aim of this study was to describe the natural history of incidental uterine venous plexus thrombosis (UVPT) and provide a structured approach to its overall management. A prospective study was conducted in a university teaching hospital over a 16-month period. Women diagnosed with UVPT on transvaginal ultrasound (TVS) were followed up over a six-month period and managed based on an individualised risk assessments, in conjunction with haematologists. Fifty women were diagnosed with UVPT during the study period, of which 38 were managed expectantly. The resolution was documented in 70% of women. There were no cases of symptomatic DVT or pulmonary embolisms in either the expectant or treatment groups. Our study has shown that in a high proportion of women, incidental UVPT could be managed successfully without the need for anticoagulation. The overall management of UVPT should be based on individualised clinical risk assessments.
Enhancing Maritime Crew Resource Management Training by Applying Resilience Engineering: A Case Study of the Bachelor Maritime Officer Training Programme in Rotterdam
Authors: Griffioen Jaco , van der Drift Monique , van den Broek Hans
Published: July 2021

This paper sets out to enhance current Maritime Crew Resource Management (MCRM) training, and with that to improve the training of technical and non-technical skills given to bachelor maritime officers. The rationale for CRM training is improving safety performance by reducing accidents caused by human error. The central notion of CRM training is that applying good resource management principles during day-to-day operations will lead to a beneficial change in attitudes and behaviour regarding safety. This article therefore indicates that enhanced MCRM should play a more structural role in the training of student officers. However, the key question is: what are the required changes in attitude and behaviour that will create sufficient adaptability to improve safety performance? To provide an answer, we introduce the Resilience Engineering (RE) theory. From an RE point of view, we elaborate on the relation between team adaptability and safety performance, operationalized as a competence profile. In addition, a case study of the ‘Rotterdam Approach’ will be presented, in which the MCRM training design has been enhanced with RE, with the objective to train team adaptability skills for improved safety performance.
Adaptive Chaotic Image Encryption Algorithm Based on RNA and Pixel Depth
Authors: Zhang Xiaoqiang , Yan Xuangang
Published: July 2021

To prevent the leakage of image content, image encryption technology has received increasing attention. Most current algorithms are only suitable for the images of certain types and cannot update keys in a timely manner. To tackle such problems, we propose an adaptive chaotic image encryption algorithm based on RNA and pixel depth. Firstly, a novel chaotic system, two-dimensional improved Logistic-adjusted-Sine map is designed. Then, we propose a three-dimensional adaptive Arnold transform for scrambling. Secondly, keys are generated by the hash values of the plain image and current time to achieve one-image, one-key, and one-time pad simultaneously. Thirdly, we build a pre-permuted RNA cube for 3D adaptive scrambling by pixel depth, chaotic sequences, and adaptive RNA coding. Finally, selective diffusion combined with pixel depth and RNA operations is performed, in which the RNA operators are determined by the chemical structure and properties of amino acids. Pixel depth is integrated into the whole procedure of parameter generation, scrambling, and diffusion. Experiments and algorithm analyses show that our algorithm has strong security, desirable performance, and a broader scope of application.
Optimization and Design of Passive Link with Single Channel 25 Gbps Based on High-Speed Backplane
Authors: Liu Jie , Zhang Kai , Wu Qiang , Peng Li , Yao Kai , Liu Hu
Published: July 2021

In recent years, with the development of the communication industry, the need to use Ethernet switches to transmit big data has become more urgent, and its protocol standards are iterating towards higher return loss, wider bandwidth, lower impedance fluctuations and insertion loss. Based on the research of high-speed backplane with a single channel 25 Gbps transmission rate, a novel double grounded planar strip coplanar waveguide design is presented, which significantly improved return loss to 20 dB and reduced insertion loss, which meet the loss standard of 100GBASE-KR4. The resonant cavity model of transmission line reference plane is improved by introducing vias and the parameters of vias in the reference plane are studied to reduce the impact of resonance, which improved the transmission −1 dB bandwidth to 60 GHz. Based on equivalent circuit analysis of differential vias’ joint reverse pad, the parameters related to the differential vias are studied, the impedance fluctuation is reduced to 100 ± 3 Ω, which is 70% better than the impedance fluctuation standard (100 ± 10 Ω) of 100GBASE-KR4. After optimizing the mathematical model of strip coplanar waveguide, reference plane and differential vias, we built a simulation model of the backplane passive link which met the 100GBASE-KR4 backplane Ethernet specification. In the actual test, it was found that the optimized model can improve the link performance.
Simplified Swarm Optimization for the Heterogeneous Fleet Vehicle Routing Problem with Time-Varying Continuous Speed Function
Authors: Yeh Wei-Chang , Tan Shi-Yi
Published: July 2021

Transportation planning has been established as a key topic in the literature and practices of social production, especially in urban contexts. To consider traffic environment factors, more and more researchers are taking time-varying factors into account when scheduling their logistic activities. The time-dependent vehicle routing problem (TDVRP) is an extension of the classical Vehicle Routing Problem with Time Windows (VRPTW) by determining a set of optimal routes serving a set of customers within specific time windows. However, few of them use the continuous speed function to express the time-varying. In practice, many vehicle routing problems are addressed by a fleet of heterogeneous vehicles with different capacities and travel costs including fix costs and variable costs. In this study, a Heterogeneous Fleet Vehicle Routing Problem (HFPRP) Time-Varying Continuous Speed Function has been proposed. The objective is to minimize distribution costs, which contained fixed costs of acquiring and variable fuel costs. To address this problem, our research developed a mathematical model and proposed a Simplified Swarm Optimization (SSO) heuristic for HFVRP with Time-Varying Continuous Speed Function.
Scalable Multiport Converter Structure for Easy Grid Integration of Alternate Energy Sources for Generation of Isolated Voltage Sources for MMC
Authors: Rahman Syed , Khan Irfan , Rahman Khaliqur , Al Otaibi Sattam , Alkhammash Hend I. , Iqbal Atif
Published: July 2021

This paper presents a novel, scalable, and modular multiport power electronic topology for the integration of multiple resources. This converter is not only scalable in terms of the integration of multiple renewable energy resources (RES) and storage devices (SDs) but is also scalable in terms of output ports. Multiple dc outputs of a converter are designed to serve as input to the stacking modules (SMs) of the modular multilevel converter (MMC). The proposed multiport converter is bidirectional in nature and superior in terms of functionality in a way that a modular universal converter is responsible for the integration of multiple RES/SDs and regulates multiple dc output ports for SMs of MMC. All input ports can be easily integrated (and controlled), and output ports also can be controlled independently in response to any load variations. An isolated active half-bridge converter with multiple secondaries acts as a central hub for power processing with multiple renewable energy resources that are integrated at the primary side. To verify the proposed converter, a detailed design of the converter-based system is presented along with the proposed control algorithm for managing power on the individual component level. Additionally, different modes of power management (emulating the availability/variability of renewable energy sources (RES)) are exhibited and analyzed here. Finally, detailed simulation results are presented in detail for the validation of the proposed concepts and design process.
Identification of Linear and Bilinear Systems: A Unified Study
Authors: Benesty Jacob , Paleologu Constantin , Dogariu Laura-Maria , Ciochină Silviu
Published: July 2021

System identification problems are always challenging to address in applications that involve long impulse responses, especially in the framework of multichannel systems. In this context, the main goal of this review paper is to promote some recent developments that exploit decomposition-based approaches to multiple-input/single-output (MISO) system identification problems, which can be efficiently solved as combinations of low-dimension solutions. The basic idea is to reformulate such a high-dimension problem in the framework of bilinear forms, and to then take advantage of the Kronecker product decomposition and low-rank approximation of the spatiotemporal impulse response of the system. The validity of this approach is addressed in terms of the celebrated Wiener filter, by developing an iterative version with improved performance features (related to the accuracy and robustness of the solution). Simulation results support the main theoretical findings and indicate the appealing performance of these developments.
Gas Permeability Model for Porous Materials from Underground Coal Gasification Technology
Authors: Wałowski Grzegorz
Published: July 2021

Underground coal gasification (UCG) technology converts deep coal resources into synthesis gas for use in the production of electricity, fuels and chemicals. This study provides an overview of the systematic methods of the in situ coal gasification process. Furthermore, the model of the porous structure of coal has been presented and the gas movement taking place in the carbon matrix—which is part of the bed—has been described. The experimental tests were carried out with the use of air forced through the nozzle in the form of a gas stream spreading in many directions in a porous bed under bubbling conditions. The gas flow resistance coefficient was determined as a function of the Reynolds number in relation to the diameter of the gas flow nozzle. The proprietary calculation model was compared to the models of many researchers, indicating a characteristic trend of a decrease in the gas flow resistance coefficient with an increase in Reynolds number. The novelty of the study is the determination of the permeability characteristics of char (carbonizate) in situ in relation to melted waste rock in situ, taking into account the tortuosity and gas permeability factors for an irregularly shaped solid.
The Influence of Radial and Axial Gaps on Volumetric Efficiency of External Gear Pumps
Authors: Szwemin Paulina , Fiebig Wieslaw
Published: July 2021

The design of gear pumps and motors is focused on more efficient units which are possible to achieve using advanced numerical simulation techniques. The flow that appears inside the gear pump is very complex, despite the simple design of the pump itself. The identification of fluid flow phenomena in areas inside the pump, considering the entire range of operating parameters, is a major challenge. This paper presents the results of simulation studies of leakages in axial and radial gaps in an external gear pump carried out for different gap shapes and sizes, as well as various operating parameters. To investigate the processes that affect pump efficiency and visualize the fluid flow phenomena during the pump’s operation, a CFD model was built. It allows for a detailed analysis of the impact of the gears’ eccentricity on leakages and pressure build-up on the circumference. Performed simulations made it possible to indicate the relationship between leakages resulting from the axial and radial gap, which has not been presented so far. To verify the CFD model, experimental investigations on the volumetric efficiency of the external gear pump were carried out. Good convergence of results was obtained; therefore, the presented CFD model is a universal tool in the study of flow inside external gear pumps.
PWM Strategy to Alleviate Common-Mode Voltage with Minimized Output Harmonic Distortion for Five-Level Cascaded H-Bridge Converters
Authors: Pham Khoa Dang , Nguyen Quan Vinh , Nguyen Nho-Van
Published: July 2021

High-frequency components of common-mode voltage (CMV) induce the shaft voltage and bearing current, which lead to premature failures in motors. In addition, due to non-zero average CMV, the low-frequency components of CMV, particularly the third-order harmonic component, have been reported to cause difficulties in common-mode filter design. Furthermore, the utilization of distant voltage vectors in the pulse-width modulation (PWM) with reduced CMV magnitudes gives rise to high output harmonic distortion compared to PWM ones without CMV reduction. In an attempt to solve the aforementioned issues, this article presents a PWM strategy that features reduced CMV magnitudes, zero average CMV, and improved output harmonic distortion for a five-level cascaded H-bridge (CHB) converter. In addition, the carrier rotation technique based on the phase-leg redundancy of the CHB topology is also combined with the proposed scheme to achieve equal power loss distribution among power switching devices. Both simulation and experimental results confirm that the proposed strategy produces better output harmonic distortion than that of POD-SPWM and APOD-SPWM under the condition of reduced CMV magnitudes, zero average CMV, and equal power loss distribution.
Miscanthus to Biocarbon for Canadian Iron and Steel Industries: An Innovative Approach
Authors: Deb Abhi Trishan , Norouzi Omid , Macdermid-Watts Kevin , Heidari Mohammad , Tasnim Syeda , Dutta Animesh
Published: July 2021

Iron-based industries are one of the main contributors to greenhouse gas (GHG) emissions. Partial substitution of fossil carbon with renewable biocarbon (biomass) into the blast furnace (BF) process can be a sustainable approach to mitigating GHG emissions from the ironmaking process. However, the main barriers of using biomass for this purpose are the inherent high alkaline and phosphorous contents in ash, resulting in fouling, slagging, and scaling on the BF surface. Furthermore, the carbon content of the biomass is considerably lower than coal. To address these barriers, this research proposed an innovative approach of combining two thermochemical conversion methods, namely hydrothermal carbonization (HTC) and slow pyrolysis, for converting biomass into suitable biocarbon for the ironmaking process. Miscanthus, which is one of the most abundant herbaceous biomass sources, was first treated by HTC to obtain the lowest possible ash content mainly due to reduction in alkali matter and phosphorous contents, and then subjected to slow pyrolysis to increase the carbon content. Design expert 11 was used to plan the number of the required experiments and to find the optimal condition for HTC and pyrolysis steps. It was found that the biocarbon obtained from HTC at 199 °C for 28 min and consecutively pyrolyzed at 400 °C for 30 min showed similar properties to pulverized coal injection (PCI) which is currently used in BFs due to its low ash content (0.19%) and high carbon content (79.67%).
Tightness of Single-Family Buildings Made in Prefabricated Wood Frame Technology
Authors: Nowoświat Artur , Pokorska-Silva Iwona , Konewecki Mateusz
Published: July 2021

The overall objective of the study is to determine the influence of various factors on the tightness of frame-based buildings. The study presents airtightness tests—Blow Doors Tests of single-family residential buildings made in the prefabricated wood frame technology. Primarily, the impact of selected quantitative and qualitative parameters on the determined quantity n50 was defined. For that purpose, correlation analyses were performed and the statistical hypothesis stating that there is no statistically significant linear relationship between n50 (a multiplication factor of air exchange in the building effected by pressure difference of 50 Pa) and the specified qualitative and quantitative parameters was verified. The hypothesis was verified using the F and χ2 statistics. The studies demonstrated that there are no grounds to reject the research hypothesis. The obtained results formulate a comprehensive conclusion that allows to test the tightness of buildings made in the prefabricated wood frame technology and makes the tightness results independent of many features of the examined building. Ultimately, the tightness results are only dependent on the leak of the examined object. They do not depend on roof structure, wall system, floor area, cubature, number of window openings, porch.
Novel Bioactive Extraction and Nano-Encapsulation
Authors: Noore Shaba , Rastogi Navin Kumar , O’Donnell Colm , Tiwari Brijesh
Published: July 2021

An extraction technology works on the principle of two consecutive steps that involves mixture of solute with solvent and the movement of soluble compounds from the cell into the solvent and its consequent diffusion and extraction. The conventional extraction techniques are mostly based on the use of mild/high temperatures (50–90 °C) that can cause thermal degradation, are dependent on the mass transfer rate, being reflected on long extraction times, high costs, low extraction efficiency, with consequent low extraction yields. Due to these disadvantages, it is of interest to develop non-thermal extraction methods, such as microwave, ultrasounds, supercritical fluids (mostly using carbon dioxide, SC-CO2), and high hydrostatic pressure-assisted extractions which works on the phenomena of minimum heat exposure with reduced processing time, thereby minimizing the loss of bioactive compounds during extraction. Further, to improve the stability of these extracted compounds, nano-encapsulation is required. Nano-encapsulation is a process which forms a thin layer of protection against environmental degradation and retains the nutritional and functional qualities of bioactive compounds in nano-scale level capsules by employing fats, starches, dextrins, alginates, protein and lipid materials as encapsulation materials.
Effects of Randomized Management on the Forest Distribution Patterns of Larix kaempferi Plantation in Xiaolongshan, Gansu Province, China
Authors: Xu Junmo , Zhang Gongqiao , Zhao Zhonghua , Hu Yanbo , Liu Wenzhen , Yang Aiming , Hui Gangying
Published: July 2021

Patterns of tree distribution are an important attribute of forest structure and directly affect the health and stability of forest ecosystems. This paper studied the effects of forest management on the forest distribution pattern of Larix kaempferi plantations with an aim to improve the quality of the spatial structure of plantations by providing scientific grounds for near-nature distribution pattern adjustment. We set up 15 long-term positioning and monitoring plots of 20 m × 20 m of L. kaempferi plantations in Xiaolongshan, Gansu Province, China, based on the Clark and Evans index, and applied the structure analysis method of the neighboring tree relationship to determine the standard angle of the uniform angle index of regularly distributed plantation forests. The changes in forest distribution patterns were compared before and after randomized management (R1 (dumbbell-shaped random unit), R2 (torch-shaped random unit) and R1:R2 = 1:2 models) and underlayer tending and unmanaged control (CK). The results showed that (1) Under different management modes, the distribution patterns obtained by the Clark and Evans index and the mean values of the uniform angle index were entirely the same; all stand patterns were evenly distributed. (2) Regardless of randomized management or underlayer tending, the number of trees in the even distribution was the largest, accounting for more than 40%. (3) The mean values of the uniform angle index of most stands increased obviously after randomized management, among which the R1 and R2 stands showed an upward trend, while the R1:R2 = 1:2 stands showed a slight decrease. However, the mean values of the uniform angle index of the stands with underlayer management showed a decreasing trend. (4) The proportion of random trees in most stands increased significantly after randomized management, increasing by 1%~19% compared with that before adjustment, while the proportion of random trees in the underlayer tending treatment decreased by 2%~10%. Our results suggest that (1) The method based on the modified uniform angle index standard angle could effectively improve the accuracy of the distribution pattern of individual trees in plantation forests and further improve the accuracy of the overall stand pattern quantitatively. (2) Randomized management significantly increased the proportion of random trees in the stands, which accelerated the evolution of the forest distribution pattern of the L. kaempferi plantation to a random distribution.
Changes in the Vietnamese Timber Processing Industry: A Case of Quang Tri Province, North Central Region
Authors: Iwanaga Seiji , Hoang Dang Thai , Kuboyama Hirofumi , Duong Dang Thai , Tuan Hoang Huy , Minh Nguyen Van
Published: July 2021

Vietnam’s forestry policies have expanded the area of planted forests in order to meet the supply of raw materials for the timber processing industry. However, the diversity and volume of demand in the industry have also increased, and a shortage of raw materials can be assumed. For clarifying the correspondence of stakeholders, we explore changes in the resource supply behavior of forestry companies and procurement strategies of companies that manufacture lumber for glued laminated timber, medium density fiberboard (MDF) and wood pellets. Next, we discuss issues and future developments surrounding the supply and demand for timber from planted forests. According to a survey of Quang Tri Province, both industrial and on-farm tree planting play an important role in Vietnam’s wood industry. The origin of the supply has been categorized according to its purpose (products). On the other hand, with the declining supply of imported timber and natural forest timber, inquiries from sawmills and glued laminated timber factories for timber from planted forests have increased, and wood pellet manufacturers are facing competition for raw material procurement with MDF manufacturers, and the supply of timber from planted forests is becoming scarce. The key to the solution lies in improving the low productivity of current on-farm tree planting. To this end, forming farmer groups upon the acquisition of forest certification will help achieve economies of scale and bargaining power.