bluuebunny/crossref_metadata_2025 huggingface dataset:
The preventive effect of dexmedetomidine on anesthesia complications in strabismus surgery: a systematic review and meta-analysis
Authors: Chen Yiren , Li Mingjie , Zheng Yajing , Chen Ailuan , Li Chengjie
Published: July 2023

Objective

Dexmedetomidine is a medication that has analgesic, sedative, and anti-anxiety properties. In the clinical, it is often used to prevent common complications associated with strabismus surgery, including postoperative delirium, postoperative nausea and vomiting, postoperative pain, and oculocardiac reflex. However, its effectiveness and side effects of the present studies are different. The sample sizes of the present studies on the prevention of complications of dexmedetomidine are small. Therefore, this study evaluates the efficacy of dexmedetomidine in preventing anesthesia-related complications in strabismus surgery through a systematic review and meta-analysis.

Methods

Literature was retrieved from 10 commonly used databases and randomized controlled trials published up to May 2022 were sought. The included studies compared the intervention effects of dexmedetomidine versus placebo on anesthesia-related complications in surgery. The occurrence rates of postoperative delirium, postoperative nausea and vomiting, postoperative pain, and oculocardiac reflex in patients undergoing strabismus surgery were evaluated. Statistical analyses and forest plots were generated using Review Manager and STATA software. Binary outcomes were measured using relative risk (RR) with a 95% confidence interval for each outcome. The Cochrane risk of bias tool was used to assess the bias and risk in the studies that met the inclusion criteria.

Results

A total of 13 articles were ultimately included in the analysis, comprising 1,018 patients who underwent strabismus surgery. The dexmedetomidine group, compared to the placebo group, demonstrated significant reductions in the incidence of postoperative delirium (RR = 0.73, P = 0.001), severe postoperative delirium (RR = 0.45, P = 0.005), postoperative nausea and vomiting (RR = 0.48, P < 0.0001), and the need for supplemental analgesia postoperatively (RR = 0.60, P = 0.004). Additionally, subgroup analysis revealed that intravenous administration of dexmedetomidine significantly reduced the incidence of oculocardiac reflex (RR = 0.50, P = 0.001). In contrast, intranasal administration of dexmedetomidine did not have a significant effect on the incidence of oculocardiac reflex (RR = 1.22, P = 0.15). There was a significant difference between the subgroups (P = 0.0005, I2 = 91.7%).

Conclusion

Among patients undergoing strabismus surgery, the use of dexmedetomidine can alleviate postoperative delirium and reduce the incidence of postoperative nausea and vomiting, as well as postoperative pain. Moreover, intravenous administration of dexmedetomidine can lower the occurrence rate of the oculocardiac reflex.
A new classification of periampullary diverticulum: cannulation of papilla on the inner margins of the diverticulum (Type IIa) is more challenging
Authors: Shi He-xian , Ye Yong-qiang , Zhao Hai-wang , Kong De-cai , Huang Shan-zhou , Yan Qian , Chen Yu-bin , Zhang Ping , Chen Sheng , Hou Bao-hua , Zhang Chuan-zhao
Published: July 2023

Background

Periampullary diverticulum (PAD) may make the performance of endoscopic retrograde cholangiopancreatography (ERCP) in patients with choledocholithiasis more difficult and may increase complication rates. The present study evaluated the effects of PAD on first-time ERCP in patients with choledocholithiasis.

Methods

Outcomes were compared in patients with and without PAD and in those with four types of PAD: papilla located completely inside the diverticulum (type I), papilla located in the inner (type II a) and outer (type II b) margins of the diverticulum; and papilla located outside the diverticulum (type III).

Parameters compared included cannulation time and rates of difficult cannulation, post-ERCP pancreatitis (PEP) and perforation.

Results

The median cannulation times in patients with types I, II a, II b, III PAD and in those without PAD were 2.0 min, 5.0 min, 0.67 min, 3.5 min, and 3.5 min, respectively, with difficult cannulation rates in these groups of 7.4%, 31.4%, 8.3%, 18.9%, and 23.2%, respectively. The rates of PEP in patients with and without PAD were 5.3% and 5.1%, respectively. Four patients with and one without PAD experienced perforation.

Conclusions

The division of PAD into four types may be more appropriate than the traditional division into three types. Cannulation of type I and II b PAD was easier than cannulation of patients without PAD, whereas cannulation of type II a PAD was more challenging. PAD may not increase the rates of PEP.
Systematic review and meta-analysis of knowledge on PMTCT of HIV/AIDS and Association factors among reproductive age women in Ethiopia, 2022
Authors: Kassie Sisay Yitayih , Chereka Alex Ayenew , Damtie Yitayish
Published: July 2023

Background

Despite increased interventions implemented for the prevention of mother-to-child transmission of HIV, There is still a vertical transmission. Hence, this study tried to assess the pooled prevalence of knowledge on PMTCT and factors associated with residence, ANC follow-up, and knowledge about HIV/AIDS among reproductive age women in Ethiopia.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed to review either published or unpublished studies in Ethiopia regarding knowledge on PMTCT. A comprehensive search of international databases, including Google Scholar, Cochrane Library, PubMed, HINARI, Embrace, Web of Science, Scopus, ProQuest, CINAHL, and Global Health, were searched. The data were analyzed using STATA/SE version 14. The random-effect model was used to estimate the effect size, and I-squared statistics and Egger’s test were used to assess the heterogeneity and publication bias, respectively.

Results

14 out of 14,091 assessed articles met inclusion criteria and were included in the analysis. The estimated pooled level of knowledge on PMTCT among reproductive-age groups was 62.15% [(95% CI: 43.63–80.66)]. Residence [(OR = 4.8, 95%CI: 2.99, 7.85)], ANC follow-up [(OR = 4.2, 95%CI: 2.21, 7.98)], and having sufficient knowledge about the diseases [(OR = 4.9, 95% CI: 3.6, 6.66)] were found to be significant predictors of knowledge on PMTCT among reproductive-age groups.

Conclusion

Strategies to improve the knowledge of PMTCT in Ethiopia should focus on rural women, improving knowledge about HIV/AIDS, and ANC follow-up. Efforts are also needed to involve husbands and related organization in the prevention of mother to child transmission of HIV.
Estimation of the relationship between meteorological factors and measles using spatiotemporal Bayesian model in Shandong Province, China
Authors: Jia Yan , Xu Qing , Zhu Yuchen , Li Chunyu , Qi Chang , She Kaili , Liu Tingxuan , Zhang Ying , Li Xiujun
Published: July 2023

Background

Measles-containing vaccine (MCV) has been effective in controlling the spread of measles. Some countries have declared measles elimination. But recently years, the number of cases worldwide has increased, posing a challenge to the global goal of measles eradication. This study estimated the relationship between meteorological factors and measles using spatiotemporal Bayesian model, aiming to provide scientific evidence for public health policy to eliminate measles.

Methods

Descriptive statistical analysis was performed on monthly data of measles and meteorological variables in 136 counties of Shandong Province from 2009 to 2017. Spatiotemporal Bayesian model was used to estimate the effects of meteorological factors on measles, and to evaluate measles risk areas at county level. Case population was divided into multiple subgroups according to gender, age and occupation. The effects of meteorological factors on measles in subgroups were compared.

Results

Specific meteorological conditions increased the risk of measles, including lower relative humidity, temperature, and atmospheric pressure; higher wind velocity, sunshine duration, and diurnal temperature variation. Taking lowest value (Q1) as reference, RR (95%CI) for higher temperatures (Q2–Q4) were 0.79 (0.69–0.91), 0.54 (0.44–0.65), and 0.48 (0.38–0.61), respectively; RR (95%CI) for higher relative humidity (Q2–Q4) were 0.76 (0.66–0.88), 0.56 (0.47–0.67), and 0.49 (0.38–0.63), respectively; RR (95%CI) for higher wind velocity (Q2–Q4) were 1.43 (1.25–1.64), 1.85 (1.57–2.18), 2.00 (1.59–2.52), respectively. 22 medium-to-high risk counties were identified, mainly in northwestern, southwestern and central Shandong Province. The trend was basically same in the effects of meteorological factors on measles in subgroups, but the magnitude of the effects was different.

Conclusions

Meteorological factors have an important impact on measles. It is crucial to integrate these factors into public health policies for measles prevention and control in China.
Migration and health research: past, present, and future
Authors: Goldenberg Shira M , Fischer Florian
Published: July 2023

Global migration continues to rise at unprecedented rates. Migrants are an extremely heterogeneous group and face diverse health needs related to infectious diseases, sexual and reproductive health, non-communicable diseases, and healthcare access across the whole lifespan. In this editorial, we set the context and invite contributions for a collection on ‘Migration and health’ at BMC Public Health.
Biomechanical and clinical evaluation of minimal invasive plate osteosynthesis for two-part clavicle shaft fractures
Authors: Schlüßler Antonia , Fehrenbacher Manuel , Richter Richard Frank , Tille Eric , Biewener Achim , Nowotny Jörg
Published: July 2023

Background

Many surgical treatment methods exist for clavicle shaft fractures. A locking compression plate (LCP) fixation with three screws per fracture side is commonly used. For certain fractures a stabilization with 2 screws per side is potentially suitable, offering the advantage of reduced soft tissue approach, while avoiding the disadvantages of minimally-invasive nailing at the same time. This hypothesis was evaluated biomechanically and clinically.

Methods

Four treatment procedures were investigated biomechanically using composite human clavicle specimens. A load-to-failure test was performed using a three-point cantilever test. In group 1, a simple shaft fracture was simulated and stabilized with 2 screws per fracture side (5-hole LCP). In the second group 3 screws per side (7-hole LCP) were used. In group 3, a non-reduced fracture zone was simulated and treated with 3 screws per side (7-hole LCP). In group 4, an anatomically reduced fracture zone was simulated and treated with 3 screws per side (7-hole LCP). Furthermore 27 patients treated with a short plate and 2 screws per side (similar to group 1) were assessed after a minimum follow-up of 12 months (Constant and DASH Score).

Results

The maximum load-to-failure of group 1 was 367N. We observed the highest load-to-failure in group 2 with 497N and the lowest in group 3 with 90N. In group 4 a maximum load-to-failure of 298N could be evaluated. There was no significant difference in load-to-failure between the treatment of a simple clavicle fracture using 5- or 7-hole LCP (p = 0.121). However, we found a significant difference of load-to-failure between the simple and anatomically reduced fracture using a 7-hole plate (p = 0.014). The mean constant score of the surgically treated patients was 95 and the DASH score 3.0. Fracture consolidation was observed in 96.3%.

Conclusions

For certain non-fragmented and well interlocking 2-part fractures, a plate osteosynthesis fixed with only 2 screws per fracture side might offer sufficient biomechanical stability, better soft tissue preservation and comparable fusion rates compared to the operative treatment with 3 screws per side. However, the maximum load-to-failure of the 7-hole LCP was higher than of the 5-hole LCP, but this difference was not statistically significant.

Trial registration

Approval from the ethics committee of the Technical University of Dresden was retrospectively obtained (EK 588122019).
Water-soluble pristine C60 fullerenes attenuate isometric muscle force reduction in a rat acute inflammatory pain model
Authors: Zavodovskiy Danylo O. , Bulgakova Nataliya V. , Sokolowska Inna , Prylutskyy Yuriy I. , Ritter Uwe , Gonchar Olga O. , Kostyukov Alexander I. , Vlasenko Oleh V. , Butowska Kamila , Borowik Agnieszka , Piosik Jacek , Maznychenko Andriy
Published: July 2023

Background

Being a scavenger of free radicals, C60 fullerenes can influence on the physiological processes in skeletal muscles, however, the effect of such carbon nanoparticles on muscle contractility under acute muscle inflammation remains unclear. Thus, the aim of the study was to reveal the effect of the C60 fullerene aqueous solution (C60FAS) on the muscle contractile properties under acute inflammatory pain.

Methods

To induce inflammation a 2.5% formalin solution was injected into the rat triceps surae (TS) muscle. High-frequency electrical stimulation has been used to induce tetanic muscle contraction. A linear motor under servo-control with embedded semi-conductor strain gauge resistors was used to measure the muscle tension.

Results

In response to formalin administration, the strength of TS muscle contractions in untreated animals was recorded at 23% of control values, whereas the muscle tension in the C60FAS-treated rats reached 48%. Thus, the treated muscle could generate 2-fold more muscle strength than the muscle in untreated rats.

Conclusions

The attenuation of muscle contraction force reduction caused by preliminary injection of C60FAS is presumably associated with a decrease in the concentration of free radicals in the inflamed muscle tissue, which leads to a decrease in the intensity of nociceptive information transmission from the inflamed muscle to the CNS and thereby promotes the improvement of the functional state of the skeletal muscle.
Evaluation of mandibular trabecular and cortical bone by fractal analysis and radiomorphometric indices in bruxist and non-bruxist patients
Authors: Çitir Mesude , Karslioglu Hazal , Uzun Canan
Published: July 2023

Background

The aim of this study was to evaluate the effect of bruxism on the cortical and trabecular bone of the mandible using the radiomorphometric indexes and fractal analysis (FA) additionally to examine the efficiency of FA as diagnostic test for bruxism.

Methods

Evaluation was performed on panoramic radiographs of 94 bruxists and 94 non-bruxist individuals with the ImageJ program. Cortical bone was assessed with mandibular cortical index, mental index, and panoramic mental index. Trabecular bone in the condyle, gonial, and corpus region was evaluated by FA. An independent sample t and Mann-Whitney-U tests and Pearson and Spearman rank correlations were conducted for statistical analysis.

Results

A total of 188 participants, 112 female, and 76 male, were included in the study. The sample age ranged from 18 to 43, with a mean of 27.55 (± 7.022) years. FA values of the angulus were significantly higher than those of the condyle and corpus, and the mean of the sample for the angulus, condyle, and corpus, respectively, were; 1.36 (± 10), 1.10 (± 0.9), 1.13 (± 0.8). There was a positive correlation between FA of the mandibular corpus and age (r = .163, p = .025). Females’ values were smaller than males’ in the FAs of three regions, and significant differences were found in FA of the condyle and angulus of the mandible, MCI, and PMI according to gender. There was no statistically significant difference between bruxist and non-bruxist patients in term of FAs of three regions, MCI, MI, and PMI values (p > .05).

Conclusions

FA of the condyle and angulus of the mandible, MCI, and PMI are significantly affected by gender. However bruxism doesn’t cause a significant change in the fractal dimensions of the bone in the mandible and doesn’t change substantially MCI, MI, and PMI.
Determinants of term premature rupture of membrane: case-control study in Saint Paul’s Millennium Medical College Hospital, Addis Ababa, Ethiopia
Authors: daniel Zelele , Tantu Temesgen , Zewdu Dereje , Mekuria Thomas , Yehualashet Tsion , Gunta Muluken , Wondosen Mekete
Published: July 2023

Background

The term premature rupture of the membranes is the rupture of the membranes before the onset of labor beyond 37 weeks of gestation. Several factors, including obstetric, gynecologic, socioeconomic, and medical, are identified as potential risk factors. This clinical event has detrimental maternal and neonatal complications.

Objectives

This study aimed to investigate the determinants of the term premature rupture of the membranes in Ethiopia.

Methods

This institution-based unmatched case-control study was conducted on 246 women admitted to Saint Paul’s hospital millennium medical college from October 2019 to January 2020 (82 cases and 164 controls). Data were collected using an interviewer-based questionnaire and data extraction tools, and data were entered using Epi data 3.1 and analyzed using SPSS 20. The association between independent variables and premature rupture of the membrane was estimated using an odds ratio with 95% confidence intervals and P-value < 0.05.

Results

Factors like a history of vaginal discharge (AOR 3.508;95% CI:1.595.7.716), place of Antenatal care follow-up (health center and Mercy Ethiopia) (AOR 5.174;95% CI:2.165,12.362), the previous history of rupture of membrane (AOR 9.955;95% CI:3.265,20.35), and gestational age (AOR 3.018;95% CI:1.338,6.811) were associated with term premature rupture of membrane. There were more maternal and neonatal complications, including puerperal sepsis, wound infection, anemia/PPH, a hospital stays of more than seven days, clinical amnionitis, neonatal hypoglycemia, early onset neonatal sepsis, and respiratory distress encountered by women who presented with premature rupture of membrane.

Conclusion

Proper screening, close monitoring, and early interventions in those mothers with identified risk factors would help to reduce its negative consequences. Moreover, the provision of continuous professional skill development and improving the quality of ANC service is needed.
The use of GRADE-CERQual in qualitative evidence synthesis: an evaluation of fidelity and reporting
Authors: Wainwright Megan , Zahroh Rana Islamiah , Tunçalp Özge , Booth Andrew , Bohren Meghan A. , Noyes Jane , Cheng Weilong , Munthe-Kaas Heather , Lewin Simon
Published: July 2023

Background

GRADE-CERQual (Confidence in the Evidence from Reviews of Qualitative Research) is a methodological approach to systematically and transparently assess how much confidence decision makers can place in individual review findings from qualitative evidence syntheses. The number of reviews applying GRADE-CERQual is rapidly expanding in guideline and other decision-making contexts. The objectives of this evaluation were, firstly, to describe the uptake of GRADE-CERQual in qualitative evidence synthesis by review authors and, secondly, to assess both reporting of and fidelity to the approach.

Methods

The evaluation had two parts. Part 1 was a citation analysis and descriptive overview of the literature citing GRADE-CERQual. Authors worked together to code and chart the citations, first by title and abstract and second by full text. Part 2 was an assessment and analysis of fidelity to, and reporting of, the GRADE-CERQual approach in included reviews. We developed fidelity and reporting questions and answers based on the most recent guidance for GRADE-CERQual and then used NVivo12 to document assessments in a spreadsheet and code full-text PDF articles for any concerns that had been identified. Our assessments were exported to Excel and we applied count formulae to explore patterns in the data. We employed a qualitative content analysis approach in NVivo12 to sub-coding all the data illustrating concerns for each reporting and fidelity criteria.

Results

233 studies have applied the GRADE-CERQual approach, with most (n = 225, 96.5%) in the field of health research. Many studies (n = 97/233, 41.6%) were excluded from full fidelity and reporting assessment because they demonstrated a serious misapplication of GRADE-CERQual, for example interpreting it as a quality appraisal tool for primary studies or reviews. For the remaining studies that applied GRADE-CERQual to assess confidence in review findings, the main areas of reporting concern involved terminology, labelling and completeness. Fidelity concerns were identified in more than half of all studies assessed.

Conclusions

GRADE-CERQual is being used widely within qualitative evidence syntheses and there are common reporting and fidelity issues. Most of these are avoidable and we highlight these as gaps in knowledge and guidance for applying the GRADE-CERQual approach.
Intimate partner violence against HIV-Positive women on ART follow-up and associated factors in public health facilities of western Ethiopia
Authors: Biranu Shibiru , Getachew Motuma , Kejela Gemechu , Kifilu Chaltu
Published: July 2023

Introduction

Intimate partner violence is the most pervasive but less recognized problem which affects millions of women world. It is more common among marginalized individuals including women affected by HIV. However, there is limited information regarding this problem among HIV-Positive Women in Ethiopia. Thus, the study was aimed to assess the magnitude and factors associated with intimate partner violence among HIV positive women in western Ethiopia.

Methods

A facility-based cross-sectional study was conducted among HIV-positive women on ART follow-up in Nekemte town. A total of 420 women were selected by the simple random sampling technique and an interviewer-administered questionnaire was used for data collection. The data were entered to EpiData version 3.1 and analyzed by SPSS version 20. Univariable and mult- variable logistic regression analysis with their corresponding odds ratio (95%CI) were computed, and statistical significance was declared at p < 0.05.

Results

The magnitude of intimate partner violence among HIV-positive Women during Lifetime and since diagnosed with HIV was 49.29%, [(95% CI: 44.3–53.6%)] and 41.67%, [(95% CI: 37.1–45.7%)] respectively. Skipping daily ART medication ≥ 6 times/month [AOR = 3.56; (95% CI 1.18, 10.74)], experiencing controlling behavior by a partner[AOR = 6.37; (95% CI 3.26, 12.44)], women inter-parental witness of violence [AOR = 1.74; (95% CI 1.09, 2.79)], women having favorable attitude that justify wife-beating [AOR = 1.76; (95% CI 1.06, 2.94)]and non-disclosure of test result to partner [AOR 0.38; (95% CI 0.22, 0.66)] were factors associated with intimate partner violence since diagnosed with HIV.

Conclusion

The magnitude of intimate partner violence among HIV-positive Women on ART follow-up was found to be high in the study area. Therefore, integrating intimate partner violence victim screening with ART services, empowering HIV-positive women, and increasing their awareness of sexual and reproductive rights is needed.
Data from the European registry for patients with McArdle disease (EUROMAC): functional status and social participation
Authors: Karazi Walaa , Scalco Renata S. , Stemmerik Mads G. , Løkken Nicoline , Lucia Alejandro , Santalla Alfredo , Martinuzzi Andrea , Vavla Marinela , Reni Gianluigi , Toscano Antonio , Musumeci Olimpia , Kouwenberg Carlyn V. , Laforêt Pascal , Millán Beatriz San , Vieitez Irene , Siciliano Gabriele , Kühnle Enrico , Trost Rebecca , Sacconi Sabrina , Durmus Hacer , Kierdaszuk Biruta , Wakelin Andrew , Andreu Antoni L. , Pinós Tomàs , Marti Ramon , Quinlivan Ros , Vissing John , Voermans Nicol C. ,   EUROMAC Consortium
Published: July 2023

Background

The European registry for individuals with GSD5 and other muscle glycogenosis (EUROMAC) was launched to register rare muscle glycogenosis in Europe, to facilitate recruitment for research trials and to learn about the phenotypes and disseminate knowledge about the diseases. A network of twenty collaborating partners from eight European countries and the US contributed data on rare muscle glycogenosis in the EUROMAC registry.

Methods

Following the initial report on demographics, neuromuscular features and comorbidity (2020), we here present the data on social participation, previous and current treatments (medication, supplements, diet and rehabilitation) and limitations. Furthermore, the following questionnaires were used: Fatigue severity scale (FSS), WHO Disability Assessment Scale (DAS 2.0), health related quality of life (SF36) and International Physical Activity Questionnaire (IPAQ).

Results

Of 282 participants with confirmed diagnoses of muscle glycogenosis, 269 had GSD5. Of them 196 (73%) completed all questionnaires; for the others, the data were incomplete. The majority, 180 (67%) were currently working. Previous medical treatments included pain medication (23%) and rehabilitation treatment (60%). The carbohydrate-rich diet was reported to be beneficial for 68%, the low sucrose diet for 76% and the ketogenic diet for 88%. Almost all participants (93%) reported difficulties climbing stairs. The median FSS score was 5.22, indicating severe fatigue. The data from the WHODAS and IPAQ was not of sufficient quality to be interpreted.

Conclusions

The EUROMAC registry have provided insight into the functional and social status of participants with GSD5: most participants are socially active despite limitations in physical and daily life activities. Regular physical activity and different dietary approaches may alleviate fatigue and pain.
Pragmatic cluster-randomized trial of home-based preventive treatment for TB in Ethiopia and South Africa (CHIP-TB)
Authors: Malhotra Akash , Nonyane Bareng Aletta Sanny , Shirey Evan , Mulder Christiaan , Hippner Piotr , Mulatu Fiseha , Ratshinanga Andani , Mitiku Petros , Cohn Silvia , Conradie Gideon , Chihota Violet , Chaisson Richard E. , Churchyard Gavin J. , Golub Jonathan , Dowdy David , Sohn Hojoon , Charalambous Salome , Bedru Ahmed , Salazar-Austin Nicole
Published: July 2023

Background

Each year, 1 million children develop TB resulting in over 200,000 child deaths. TB preventive treatment (TPT) is highly effective in preventing TB but remains poorly implemented for household child contacts. Home-based child contact management and TPT services may improve access to care. In this study, we aim to evaluate the effectiveness and cost-effectiveness of home-based contact management with TPT initiation in two TB high-burden African countries, Ethiopia and South Africa.

Methods

This pragmatic cluster randomized trial compares home-based versus facility-based care delivery models for contact management. Thirty-six clinics with decentralized TB services (18 in Ethiopia and 18 in South Africa) were randomized in a 1:1 ratio to conduct either home-based or facility-based contact management. The study will attempt to enroll all eligible close child contacts of infectious drug-sensitive TB index patients diagnosed and treated for TB by one of the study clinics. Child TB contact management, including contact tracing, child evaluation, and TPT initiation and follow-up, will take place in the child’s home for the intervention arm and at the clinic for the control arm. The primary outcome is the cluster-level ratio of the number of household child contacts less than 15 years of age in Ethiopia and less than 5 years of age in South Africa initiated on TPT per index patient, comparing the intervention to the control arm. Secondary outcomes include child contact identification and the TB prevention continuum of care. Other implementation outcomes include acceptability, feasibility, fidelity, cost, and cost-effectiveness of the intervention.

Discussion

This implementation research trial will determine whether home-based contact management identifies and initiates more household child contacts on TPT than facility-based contact management.

Trial registration

NCT04369326. Registered on April 30, 2020.
Interleukin-1β inhibitors for the management of acute gout flares: a systematic literature review
Authors: Schlesinger Naomi , Pillinger Michael H. , Simon Lee S. , Lipsky Peter E.
Published: July 2023

Objectives

The objective of this systematic review was to assess the effects of interleukin-1β (IL-1β) inhibitors on gout flares.

Methods

Studies published between 2011 and 2022 that evaluated the effects of IL-1β inhibitors in adult patients experiencing gout flares were eligible for inclusion. Outcomes including pain, frequency and intensity of gout flares, inflammation, and safety were assessed. Five electronic databases (Pubmed/Medline, Embase, Biosis/Ovid, Web of Science and Cochrane Library) were searched. Two independent reviewers performed study screening, data extraction and risk of bias assessments (Cochrane Risk of Bias Tool 2 for randomised controlled trials [RCTs] and Downs and Black for non-RCTs). Data are reported as a narrative synthesis.

Results

Fourteen studies (10 RCTs) met the inclusion criteria, with canakinumab, anakinra, and rilonacept being the three included IL-1β inhibitors. A total of 4367 patients with a history of gout were included from the 14 studies (N = 3446, RCTs; N = 159, retrospective studies [with a history of gout]; N = 762, post hoc analysis [with a history of gout]). In the RCTs, canakinumab and rilonacept were reported to have a better response compared to an active comparator for resolving pain, while anakinra appeared to be not inferior to an active comparator for resolving pain. Furthermore, canakinumab and rilonacept reduced the frequency of gout flares compared to the comparators. All three medications were mostly well-tolerated compared to their comparators.

Conclusion

IL-1β inhibitors may be a beneficial and safe medication for patients experiencing gout flares for whom current standard therapies are unsuitable.

Review protocol registration

PROSPERO ID: CRD42021267670.
Eating disorder risk in adolescent and adult female athletes: the role of body satisfaction, sport type, BMI, level of competition, and training background
Authors: Borowiec Joanna , Banio-Krajnik Adrianna , Malchrowicz-Mośko Ewa , Kantanista Adam
Published: July 2023

Background

Eating disorders negatively influence athletes’ health and performance. To achieve a high level of performance and conform to cultural expectations regarding an athletic body type, female athletes often restrict their diets, which can lead to eating disorders. In addition to factors related to the sports environment, adolescent athletes are subject to changes caused by the maturation process. Therefore, the same factors may have different effects on eating disorder risk among adolescent and adult athletes. This study examined the relationship between eating disorder risk, specific aspects of the sports environment (sport type, level of competition [national and international], and training background), and individual aspects (body satisfaction and body mass index) in two groups of athletes: adolescents and adults.

Methods

The sample included 241 highly trained female athletes aged 12–30 years (M = 20.68, SD = 4.45) recruited from different sports clubs in Poland. The subgroup of adolescents consisted of 82 athletes, while the number of adult athletes was 159. The Eating Attitudes Test questionnaire was used to assess the eating disorder risk among the athletes. Body satisfaction was measured using the Feelings and Attitudes Toward Body Scale incorporated into the Body Investment Scale.

Results

Eating disorder risk was prevalent among 14.6% of the adolescent and 6.9% of the adult athletes. Significant associations between eating disorder risk and the studied variables were noted only among adolescent athletes. Univariate logistic regression analysis revealed that the occurrence of eating disorder risk was associated with participation in lean non-aesthetic sports (OR = 11.50, 95% CI: 3.58–37.09). Moreover, eating disorder risk was associated with athletes’ lower body satisfaction (OR = 0.80, 95% CI: 0.70–0.92). Body mass index was not included in the final regression model.

Conclusions

The study indicated that eating disorder risk in adolescent female athletes was related to sport type and body satisfaction. The findings showed that, in adolescent athletes, eating disorder risk was the most associated with practicing lean non-aesthetic sports. Coaches and athletes should be aware that eating disorder risk increases among individuals with a lower body image.
Understanding the social inclusion needs of people living in mental health supported accommodation
Authors: Eager Sharon , Killaspy Helen , C Joanna , Mezey Gillian , Downey Megan , Lloyd-Evans Brynmor
Published: July 2023

Objectives

To identify the social inclusion needs that were (i) most commonly identified and (ii) most and least commonly prioritised as support planning goals for mental health service users living in supported accommodation, using the online Social Inclusion Questionnaire User Experience (SInQUE). We qualitatively examined mental health supported accommodation staff and servicer users’ views on barriers to offering support with two less commonly prioritised areas: help finding a partner and feeling less lonely.

Methods

Anonymous SInQUE data were collected during a completed study in which we developed and tested the online SInQUE. Four focus groups were conducted with mental health supported accommodation staff (N = 2) and service users (N = 2).

Results

The most common social inclusion needs identified by service users (N = 31) were leisure activities, finding transport options, and feeling less lonely. Of the needs identified, those that service users and staff least frequently prioritised as support planning goals were having company at mealtimes, getting one’s own furniture, feeling less lonely, help with finances, and help finding a partner. In the focus groups, staff and service users identified barriers to helping with loneliness and finding a partner which related to staff and service users themselves, supported accommodation services, and wider societal factors.
Dual stochastic descriptions of streamflow dynamics under model ambiguity through a Markovian embedding
Authors: Yoshioka Hidekazu , Yoshioka Yumi
Published: July 2023

Hamilton–Jacobi–Bellman equation (HJBE) and backward stochastic differential equation (BSDE) are the two faces of stochastic control. We explore their equivalence focusing on a system of self-exciting and affine stochastic differential equations (SDEs) arising in streamflow dynamics. Our SDE is a finite-dimensional Markovian embedding of an infinite-dimensional jump-driven process called the superposition of continuous-state branching processes (a supCBI process). We formulate new ergodic control problems to evaluate the worst-case streamflow discharge in the long run and derive their HJBEs and ergodic BSDEs. The constant ambiguity aversion classically used in assessing model ambiguity must be modified in our case so that the optimality equations become well-posed. With a suitable modification of the ambiguity-aversion coefficient depending on the distributed reversion speed, we demonstrate that the solutions to the optimality equations are equivalent to each other in the sense that they lead to the same result. Finally, we apply the proposed framework to the computation of realistic cases with an existing record of discharge through a numerical Markovian embedding.
Deer antler renewal gives insights into mammalian epimorphic regeneration
Authors: Li Chunyi
Published: July 2023

Deer antlers are the only known mammalian organ that, once lost, can fully grow back naturally. Hence, the antler offers a unique opportunity to learn how nature has solved the problem of mammalian epimorphic regeneration (EpR). Comprehensive comparisons amongst different types of EpR reveal that antler renewal is fundamentally different from that in lower vertebrates such as regeneration of the newt limb. Surprisingly, antler renewal is comparable to wound healing over a stump of regeneration-incompetent digit/limb, bone fracture repair, and to a lesser extent to digit tip regeneration in mammals. Common to all these mammalian cases of reaction to the amputation/mechanical trauma is the response of the periosteal cells at the distal end/injury site with formation of a circumferential cartilaginous callus (CCC). Interestingly, whether the CCC can proceed to the next stage to transform to a blastema fully depends on the presence of an interactive partner. The actual form of the partner can vary in different cases with the nail organ in digit tip EpR, the opposing callus in bone fracture repair, and the closely associated enveloping skin in antler regeneration. Due to absence of such an interactive partner, the CCC of a mouse/rat digit/limb stump becomes involuted gradually. Based on these discoveries, we created an interactive partner for the rat digit/limb stump through surgically removal of the interposing layers of loose connective tissue and muscle between the resultant CCC and the enveloping skin after amputation and by forcefully bonding two tissue types tightly together. In so doing partial regeneration of the limb stump occurred. In summary, if EpR in humans is to be realized, then I envisage that it would be more likely in a manner akin to antler regeneration rather to that of lower vertebrates such as newt limbs.
Optimizing quasi-cyclic spatially coupled LDPC codes by eliminating harmful objects
Authors: Battaglioni Massimo , Chiaraluce Franco , Baldi Marco , Pacenti Michele , Mitchell David G. M.
Published: July 2023

It is well known that some harmful objects in the Tanner graph of low-density parity-check (LDPC) codes have a negative impact on their error correction performance under iterative message-passing decoding. Depending on the channel and the decoding algorithm, these harmful objects are different in nature and can be stopping sets, trapping sets, absorbing sets, or pseudocodewords. Differently from LDPC block codes, the design of spatially coupled LDPC codes must take into account the semi-infinite nature of the code, while still reducing the number of harmful objects as much as possible. We propose a general procedure, based on edge spreading, enabling the design of good quasi-cyclic spatially coupled LDPC (QC-SC-LDPC) codes. These codes are derived from quasi-cyclic LDPC (QC-LDPC) block codes and contain a considerably reduced number of harmful objects with respect to the original QC-LDPC block codes. We use an efficient way of enumerating harmful objects in QC-SC-LDPCCs to obtain a fast algorithm that spans the search space of potential candidates to select those minimizing the multiplicity of the target harmful objects. We validate the effectiveness of our method via numerical simulations, showing that the newly designed codes achieve better error rate performance than codes presented in previous literature.
An improved real-time detection algorithm based on frequency interpolation
Authors: Shi Heping , Yang Zikai , Shi Jin
Published: July 2023

Real-time monitoring of heart rate (HR), i.e., extraction of heart rate variability (HRV), plays an important role in diagnosis and prevention of cardiovascular diseases. Compared with traditional contact monitoring devices, the use of continuous wave (CW) Doppler radar to monitor HRV does not require contact and is not sensitive to light and temperature, which makes it more and more popular. To monitor the HRV based on CW Doppler radar, the time window must be shortened to less than 5 s, which will lead to the spectrum leakage and degrade the measurement accuracy of HRV. To solve this problem, a custom CW Doppler radar has been developed in an integrated fashion on a single PCB, whose transmitting frequency and power of the radar are 24 GHz and 3 dBm, respectively. Furthermore, four frequency interpolation algorithms are introduced to compare their extraction accuracy. Experiments are performed on three subjects, and results show that the Quinn algorithm can obtain best HRV extraction results compared with other algorithms. Specially, the average HRV extraction error is 3.61% using the Quinn algorithm.
Expanding the range of the respiratory infectome in Australian feedlot cattle with and without respiratory disease using metatranscriptomics
Authors: Brito Barbara P. , Frost Melinda J. , Anantanawat Kay , Jaya Frederick , Batterham Tony , Djordjevic Steven P. , Chang Wei-Shan , Holmes Edward C. , Darling Aaron E. , Kirkland Peter D.
Published: July 2023

Background

Bovine respiratory disease (BRD) is one of the most common diseases in intensively managed cattle, often resulting in high morbidity and mortality. Although several pathogens have been isolated and extensively studied, the complete infectome of the respiratory complex consists of a more extensive range unrecognised species. Here, we used total RNA sequencing (i.e., metatranscriptomics) of nasal and nasopharyngeal swabs collected from animals with and without BRD from two cattle feedlots in Australia.

Results

A high abundance of bovine nidovirus, influenza D, bovine rhinitis A and bovine coronavirus was found in the samples. Additionally, we obtained the complete or near-complete genome of bovine rhinitis B, enterovirus E1, bovine viral diarrhea virus (sub-genotypes 1a and 1c) and bovine respiratory syncytial virus, and partial sequences of other viruses. A new species of paramyxovirus was also identified. Overall, the most abundant RNA virus, was the bovine nidovirus. Characterisation of bacterial species from the transcriptome revealed a high abundance and diversity of Mollicutes in BRD cases and unaffected control animals. Of the non-Mollicutes species, Histophilus somni was detected, whereas there was a low abundance of Mannheimia haemolytica.

Conclusion

This study highlights the use of untargeted sequencing approaches to study the unrecognised range of microorganisms present in healthy or diseased animals and the need to study previously uncultured viral species that may have an important role in cattle respiratory disease.
Determinants of neural tube defects among newborns in public referral hospitals in Eastern Ethiopia
Authors: Mohamed Fadumo Ahmed , Dheresa Merga , Raru Temam Bashir , yusuf Newas , Hassen Tahir Ahmed , Mehadi Ame , Wilfong Tara , Tukeni Kedir Negesso , Kure Mohammed Abdurke , Roba Kedir Teji
Published: July 2023

Background

Neural tube defects (NTDs) are serious brain and spine birth defects. Although NTDs are primarily pregnancy complications, such as abortion and stillbirth, they also contribute to under-five morbidity and mortality, as well as long-term disability and psychological impact. Despite these negative outcomes, the determinants of NTDs are not widely studied in Ethiopia, particularly in the country’s east. As a result, we sought to identify the risk factors for NTDs in neonates born in public referral hospitals in eastern Ethiopia.

Methods

A facility-based unmatched case-control study was carried out at Hiwot Fana Comprehensive Specialized Hospital and Sheik Hassen Yabare Jigjiga University Referral Hospital in Eastern Ethiopia. We included 59 cases identified in the selected facilities between September 10, 2021, and February 5, 2022, and 118 control neonates, with a case-to-control ratio of 1:2. Data were gathered through the use of interviewer-administered questionnaires and medical record review. To identify determinant factors of NTDs, a multivariable logistic regression model was used, which included all predictor variables from the bivariable analysis. The results were reported using an Adjusted Odds Ratio (AOR) with a 95% confidence interval. A p-value of < 0.05 was considered statistically significant.

Results

In total, 59 cases of NTDs were identified out of 2915 live birth total births registered in the two hospitals, making the incidence of NTDs 202.4/10,000 births. In the final model analysis, determinant factors such as gender of newborn [AOR = 2.97; 95%CI(1.27, 6.92)], having no history of antenatal care[AOR = 4.45;95%CI(1.30,15.20)], having a poor food consumption score (AOR = 3.38;95% CI;1.06,10.72), having history of monotonous diet consumption (AOR = 4.80; 95%CI: 1.09, 9.08; P = 0.038), and coffee consumption of three or more cups per day during pregnancy (AOR = 3.84:95% CI: 1.23, 11.97) were statistically associated with NTDs.

Conclusion

Modifiable and non-modifiable determinants were identified as major contributors of neural tube defect in this study. Early screening, dietary intervention counseling to increase consumption of a healthy diet, coffee consumption reduction, and pre-pregnancy supplementation programs should be developed to reduce NTDs in Ethiopia.
Prevalence and impact of comorbidities in hospitalized patients with COVID-19: a study from Saudi Arabia
Authors: alqahtani Saad M. A. , Al Saglan Naif S. , AlShehry Ali A. , Hawan Ali , A.Dafalla Badraltamam A. , Mohamed Nahid A. S. , Kadasah Ali S. , A.Qureshi Muhammad , Al-Shahrani Nourah A. , Alfaifi Abdulaziz S. Y. , Alqahtani Mohammed A. , Alshafa Fawwaz A. , Alsalem Ali A. , Al-Imamah Yahya A. , Abdullah Alahmari , Alzulfah Saad A. S. , Mahmoud Ibrahim M. A. , Abuelhassan Usama E.
Published: July 2023

Background

In this study, we aimed to address the prevalence of comorbidities and their impact on the outcomes of hospitalized COVID-19 patients admitted to a large tertiary Saudi Arabian hospital.

Methods

This is a retrospective study that included all adults with COVID‑19 admitted to a large tertiary Saudi Arabian hospital, between January 1, 2021, and September 30, 2022. The study outcomes were the prevalence of comorbidities among hospitalized COVID-19 patients and the effects of these comorbidities on all‑cause hospital mortality.

Results

A total of 1118 /1853 (60.3%) patients had one or more comorbidities. The most prevalent comorbidity was diabetes mellitus (48.5%), followed by hypertension (12.5%), and chronic renal disease (10.3%). Age (OR 3.032 (95% CI 0.006 – 0.029, p = 0.002), clinical status (8.194, 0.0350 – 0.709, p < 0.001), the presence (versus absence) of comorbidities (3.167, 0.042—0.233, p = 0.002), the number of comorbidities (2.972, 0.027 – 0.133, p = 0.003), and the 4C score (2.894, 0.010 – 0.054, p = 0.004), were independent significant predictors of mortality.

Conclusions

A total of 60.3% of hospitalized COVID-19 patients had one or more comorbidities, the most prevalent of which were diabetes mellitus, hypertension, and chronic renal disease. The presence and the number of comorbidities, but not the individual ones, together with age, clinical status at admission, and the 4C mortality score were significant independent predictors of mortality.
“Why Me?”, a Question of Opportunity
Authors: Wein Simon
Published: July 2023

In accepting the reality of illness we are better able to make rational decisions about our health.
Sexual Fluidity: Implications for Population Research
Authors: Mittleman Joel
Published: July 2023

For the first time ever, national censuses have begun asking adults to report their sexual orientations. However, because such surveys provide only cross-sectional snapshots of populations, these data obscure one key complexity: that sexuality can be fluid, with sexual self-identification evolving over time. Drawing on unique, restricted-use data from the Population Assessment of Tobacco and Health, the current study documents the prevalence, correlates, and empirical consequences of sexual fluidity in the contemporary United States. Overall, about 1 in 11 American adults changed sexual identities over five annual surveys, including 6% of cisgender men, 11% of cisgender women, and 35% of gender minorities. Fluidity was particularly pronounced among young adults and among those who had ever identified as bisexual or “something else.” Despite the frequency and patterning of sexual fluidity, accounting for fluidity did little to change observed patterns of disadvantage on three measures of sexual minority well-being: mental health, financial insecurity, and substance use. Given these facts, I argue that demographic research should foreground the complexities inherent in quantifying sexuality, focusing less on how many people “are” a given sexual orientation and more on the social dynamics that continue to produce sexual minority disadvantage.