bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved Coupled Tensor Factorization with Its Applications in Health Data Analysis
Authors: Wu Qing , Wang Jie , Fan Jin , Xu Gang , Wu Jia , Johnson Blake , Li Xingfei , Do Quan , Ge Ruiquan
Published: February 2019

Coupled matrix and tensor factorizations have been successfully used in many data fusion scenarios where datasets are assumed to be exactly coupled. However, in the real world, not all the datasets share the same factor matrices, which makes joint analysis of multiple heterogeneous sources challenging. For this reason, approximate coupling or partial coupling is widely used in real‐world data fusion, with exact coupling as a special case of these techniques. However, to fully address the challenge of tensor factorization, in this paper, we propose two improved coupled tensor factorization methods: one for approximately coupled datasets and the other for partially coupled datasets. A series of experiments using both simulated data and three real‐world datasets demonstrate the improved accuracy of these approaches over existing baselines. In particular, when experiments on MRI data is conducted, the performance of our method is improved even by 12.47% in terms of accuracy compared with traditional methods.
Naomaitai Ameliorated Brain Damage in Rats with Vascular Dementia by PI3K/PDK1/AKT Signaling Pathway
Authors: Huang Kui , Shen Lei , Niu Tieming , Zhao Ying , Fu Jiucun , Cao Yunpeng
Published: February 2019

Background/Aims. Naomaitai can improve blood perfusion and ameliorate the damage in the paraventricular white matter. This study was focused on observing the neuroprotective effect of Naomaitai on the vascular dementia of rat and exploring the action mechanism of PI3K/PDK1/AKT signaling pathway.Methods.A vascular dementia model of rats was established by permanent, bilateral common carotid artery occlusion. Rats’ behavior was tested by Neurological deficit score and the Morris water maze. The pathology and apoptosis were detected through HE staining and TUNEL assay. Myelin sheath loss and nerve fiber damage were detected by LFB staining. Inflammatory factors, oxidative stress, and brain damage markers were detected through ELISA. The expression of apoptosis-related proteins and PI3K/PDK1/AKT signaling pathway related proteins were measured by western blot. The expressions of PI3K, PDK1, AKT, and MBP in paraventricular white matter cells were detected by immunofluorescence.Results. Naomaitai treatment decreased neurological function score in rats with vascular dementia, ameliorated paraventricular white matter damage caused by long-term hypoxia, and hypoperfusion reduced the brain injury markers S-100βand NSE contents, suppressed inflammatory reaction and oxidative stress, reduced IL-1β, IL-6, TNF-α, and MDA contents, and remarkably increased IL-10 and SOD contents. TUNEL and western blot assay showed that Naomaitai treatment decreased neuronal cell apoptosis, increased Bcl-2 expression, and reduced caspase-3 and Bax expression. Furthermore, we found Naomaitai inhibited PI3K and PDK1 expression and activated phosphorylated AKT protein in rats with vascular dementia. However, the protective effect of Naomatai in rats with vascular dementia was inhibited, and expression of PI3K signaling pathway-related proteins was blocked after administration of PI3K inhibitor.Conclusion. Naomaitai can ameliorate brain damage in rats with vascular dementia, inhibit neuronal apoptosis, and have anti-inflammatory and antioxidative stress effects, which may be regulated by the PI3K/PDK1/AKT signaling pathway.
Changes in Lipid Indices in HIV+ Cases on HAART
Authors: Ji Shujing , Xu Yufan , Han Dating , Peng Xiuming , Lu Xiangyun , Brockmeyer Norbert H. , Wu Nanping
Published: February 2019

We assess long-term changes in lipid levels in human immunodeficiency disease- (HIV-) infected patients undergoing highly active antiretroviral treatment (HAART) and their association with diabetes mellitus (DM) and thyroid dysfunction. We observed changes in the levels of total cholesterol (TC) and total triglyceride (TG) of 63 HIV-infected patients in the 6 years from starting HAART and analyzed correlations between relevant parameters. TC levels of patients with normal baseline TC levels as well as those diagnosed with DM or impaired fasting glucose (IFG) increased significantly (P  < 0.05) as did the TG levels of patients with normal baseline TG levels (P  < 0.05). TC levels of patients with hypercholesterolemia in the year HAART was initiated were significantly higher than those of patients with normal baseline TC levels (P  < 0.05) for all 6 years. TC levels of patients diagnosed with DM were significantly higher than those with euglycemia (P  < 0.05) 2 and 4 years after HAART commencement. Levels of TC, high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were correlated negatively with viral load, whereas levels of TC and very-low-density lipoprotein-cholesterol (VLDL-C) were correlated positively with CD4+ cell counts before HAART commencement. Linear mixed-effect model demonstrated disturbance of glucose metabolism and HAART containing nevirapine and CD4+ cell count were positively correlated with TC levels after HAART commencement. These findings suggest that there are changes in the lipid levels of patients undergoing HAART, with the potential risk of dyslipidemia.
Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species
Authors: Eid M. M. , El-Hallouty S. M. , El-Manawaty M. , Abdelzaher F. H.
Published: February 2019

In this work we aim to manipulate green route for the synthesis of core-shell maghemite-based Ag nanoparticles functionalized with chitosan. Three fungal species, Aspergillus deflectus, Fusarium oxysporum, and Penicillium pinophilum, were used in the process of synthesis to select the best among them for the production. The physicochemical parameters of produced nanoparticles and mediated cytotoxicity assessment for their potential medical application have been performed using Fourier transform infrared (FTIR), UV/visible, vibrating sample magnetometer (VSM), dynamic light scattering (DLS), high-resolution transmission electron microscope (HRTEM), EDAX, and MTT to plot a cytotoxicity assessment report. The results confirmed the formation of monodispersed γFe2O3@Ag@chitosan with low cytotoxicity against prostate (PC3), liver (HepG2), column (HCT116), and breast cancer (MCF7) ATCC cell lines. In conclusion, these results prove the success of the green route used for the biosynthesis of γFe2O3@Ag@chitosan with parameters necessary for bioimaging, drug and gene delivery, and biosensing.
Genome-Wide Plasma Cell-Free DNA Methylation Profiling Identifies Potential Biomarkers for Lung Cancer
Authors: Xu Wei , Lu Jun , Zhao Qiang , Wu Jun , Sun Jielin , Han Baohui , Zhao Xiaodong , Kang Yani
Published: February 2019

As a noninvasive blood testing, the detection of cell-free DNA (cfDNA) methylation in plasma has raised an increasing interest due to diagnostic applications. Although extensively used in cfDNA methylation analysis, bisulfite sequencing is less cost-effective. In this study, we investigated the cfDNA methylation patterns in lung cancer patients by MeDIP-seq. Compared with the healthy individuals, 330 differentially methylated regions (DMRs) at gene promoters were identified in lung cancer patients with 33 hypermethylated and 297 hypomethylated regions, respectively. Moreover, these hypermethylated genes were validated with the publicly available DNA methylation data, yielding a set of ten significant differentially methylated genes in lung cancer, including B3GAT2, BCAR1, HLF, HOPX, HOXD11, MIR1203, MYL9, SLC9A3R2, SYT5, and VTRNA1-3. Our study demonstrated MeDIP-seq could be effectively used for cfDNA methylation profiling and identified a set of potential biomarker genes with clinical application for lung cancer.
Optimized Packing Clusters of Objects in a Rectangular Container
Authors: Romanova T. , Pankratov A. , Litvinchev I. , Pankratova Yu. , Urniaieva I.
Published: February 2019

A packing (layout) problem for a number of clusters (groups) composed of convex objects (e.g., circles, ellipses, or convex polygons) is considered. The clusters have to be packed into a given rectangular container subject to nonoverlapping between objects within a cluster. Each cluster is represented by the convex hull of objects that form the cluster. Two clusters are said to be nonoverlapping if their convex hulls do not overlap. A cluster is said to be entirely in the container if so is its convex hull. All objects in the cluster have the same shape (different sizes are allowed) and can be continuously translated and rotated. The objective of optimized packing is constructing a maximum sparse layout for clusters subject to nonoverlapping and containment conditions for clusters and objects. Here the term sparse means that clusters are sufficiently distant one from another. New quasi‐phi‐functions and phi‐functions to describe analytically nonoverlapping, containment and distance constraints for clusters are introduced. The layout problem is then formulated as a nonlinear nonconvex continuous problem. A novel algorithm to search for locally optimal solutions is developed. Computational results are provided to demonstrate the efficiency of our approach. This research is motivated by a container‐loading problem; however similar problems arise naturally in many other packing/cutting/clustering issues.
Numerical Simulation of Ore Particle Flow Behaviour through a Single Drawpoint under the Influence of a Flexible Barrier
Authors: Chen Qingfa , Qin Shikang , Chen Qinglin
Published: February 2019

A model of the mass draw and synchronous filling no-top-pillar shrinkage stoping method was created based on the particle element theory and PFC2D software. A numerical simulation of the ore particle flow behaviour through a single drawpoint under the influence of a flexible barrier was performed; following which, a visualization of the change process in the marked layers, draw column, flexible barrier, and cavity was obtained. Finally, the results demonstrated the following. (1) Before the ore particles at the highest horizon were drawn, the morphology of the draw column had an ellipsoidal (whole, closed, and approximate) shape, but after the ore particles were drawn, the morphology of the draw column had a gyroscopic shape (i.e., the shape of a spinning top). (2) The height of the draw column increased rapidly and exponentially in the early period of the draw, presented a linear growth tendency during the medium period with an increase in the accumulated mass drawn, and remained at a certain value in the later period. (3) The morphology of the flexible barrier presented a Gaussian distribution on the whole, but its bottom had an analogous parabola morphology, particularly in the late stage. (4) The cavity began to form with the ore particles at the highest horizon drawn; the cavity development presented an evolutionary process from the microscopic to macroscopic regime, and the morphology of the cavity was crescent in the early stage and triangular in the late stage.
Double Delayed Feedback Control of a Nonlinear Finance System
Authors: Jiang Zhichao , Guo Yanfen , Zhang Tongqian
Published: February 2019

In this paper, a class of chaotic finance system with double delayed feedback control is investigated. Firstly, the stability of equilibrium and the existence of periodic solutions are discussed when delays change and cross some threshold value. Then the properties of the branching periodic solutions are given by using center manifold theory. Further, we give an example and numerical simulation, which implies that chaotic behavior can be transformed into a stable equilibrium or a stable periodic solution. Also, we give the local sensitivity analysis of parameters on equilibrium.
Macrophage Migration Inhibitory Factor Levels in Gingival Crevicular Fluid, Saliva, and Serum of Chronic Periodontitis Patients
Authors: Ortiz-García Yveth Marlene , García-Iglesias Trinidad , Morales-Velazquez Gabriela , Lazalde-Ramos Blanca Patricia , Zúñiga-González Guillermo Moisés , Ortiz-García Ramón Guillermo , Zamora-Perez Ana Lourdes
Published: February 2019

Chronic periodontitis (CP) is an infection that affects the teeth supporting structure. Macrophage migration inhibitory factor (MIF) is an important effector cytokine of the innate immune system. Due to its functional characteristics, MIF may be involved in the immunopathology of CP. The aim of the present study was to evaluate MIF levels in gingival crevicular fluid (GCF), saliva, and serum of CP patients. A cross-sectional study was conducted on 60 subjects divided into two groups: subjects with CP (n= 30) and periodontally healthy subjects without CP (n=30). MIF was quantified in GCF, saliva, and serum of all participants by enzyme-linked immunosorbent assay. MIF concentrations were higher in GCF, saliva, and serum in the group with CP compared with the group without CP and a higher MIF concentration was observed in GCF (p=0.001) and saliva (p=0.009) in the group with CP. MIF intragroup comparisons between fluids demonstrated significant high levels of MIF in saliva compared with GCF and serum in both study groups (p<0.05). A positive correlation was found between clinical signs and MIF concentration in GCF (p<0.05). There is an association between the MIF and the clinical signs of the disease. Therefore, MIF could have an important role in the pathology and progression of CP.
A Digital Mode-Matching Control System Based on Feedback Calibration for a MEMS Gyroscope
Authors: Yang Bo , Wu Lei , Lu Chengfu , Wang Gang
Published: February 2019

A digital mode-matching control system based on feedback calibration, where two pilot tones are applied to actuate the sense mode by the robust feedback controller, is presented for a MEMS gyroscope in this paper. A dual-mass decoupled MEMS gyroscope with the integrated electrostatic frequency tuning mechanisms, the quadrature correction electrode, and the feedback electrode is adopted to implement mode-matching control. Compared with the previous mode-matching method of forward excitation calibration, the proposed mode-matching scheme based on feedback calibration has better adaptability to the variation in the frequency of calibration pilot tones and the quality factor of the sense mode. The influences of calibration pilot tone frequency and the amplitude ratio on tuning performance are studied in theory and simulation. The simulation results demonstrate that the tuning error due to the amplitude asymmetry of the sense mode increases with a frequency split between pilot tones and the drive mode and is significantly reduced by the amplitude correction technology of pilot tones. In addition, the influence of key parameters on the stability of the mode-matching system is deduced by using the average analysis method. The MATLAB simulation of the mode-matching control system illustrates that simulation results have a good consistency with theoretical analysis, which verifies the effectiveness of the closed-loop mode-matching control system. The entire mode-matching control system based on a FPGA device is implemented combined with a closed-loop self-excitation drive, closed-loop force feedback control, and quadrature error correction control. Experimental results demonstrate that the mode-matching prototype has a bias instability of 0.63°/h and ARW of 0.0056°/h1/2. Compared with the mode-mismatched MEMS gyroscope, the performances of bias instability and ARW are improved by 3.81 times and 4.20 times, respectively.
Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner
Authors: Harlow Matt L. , Chasse Maggie H. , Boguslawski Elissa A. , Sorensen Katie M. , Gedminas Jenna M. , Kitchen-Goosen Susan M. , Rothbart Scott B. , Taslim Cenny , Lessnick Stephen L. , Peck Anderson S. , Madaj Zachary B. , Bowman Megan J. , Grohar Patrick J.
Published: February 2019

Purpose:

The successful clinical translation of compounds that target specific oncogenic transcription factors will require an understanding of the mechanism of target suppression to optimize the dose and schedule of administration. We have previously shown trabectedin reverses the gene signature of the EWS-FLI1 transcription factor. In this report, we establish the mechanism of suppression and use it to justify the reevaluation of this drug in the clinic in patients with Ewing sarcoma.

Experimental Design: We demonstrate a novel epigenetic mechanism of trabectedin using biochemical fractionation and chromatin immunoprecipitation sequencing. We link the effect to drug schedule and EWS-FLI1 downstream target expression using confocal microscopy, qPCR, Western blot analysis, and cell viability assays. Finally, we quantitate target suppression within the three-dimensional architecture of the tumor in vivo using 18F-FLT imaging.

Results:

Trabectedin evicts the SWI/SNF chromatin-remodeling complex from chromatin and redistributes EWS-FLI1 in the nucleus leading to a marked increase in H3K27me3 and H3K9me3 at EWS-FLI1 target genes. These effects only occur at high concentrations of trabectedin leading to suppression of EWS-FLI1 target genes and a loss of cell viability. In vivo, low-dose irinotecan is required to improve the magnitude, penetrance, and duration of target suppression in the three-dimensional architecture of the tumor leading to differentiation of the Ewing sarcoma xenograft into benign mesenchymal tissue.

Conclusions:

These data provide the justification to evaluate trabectedin in the clinic on a short infusion schedule in combination with low-dose irinotecan with 18F-FLT PET imaging in patients with Ewing sarcoma.
Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO–AACR Research Workshop
Authors: McGee Heather M. , Jiang Dadi , Soto-Pantoja David R. , Nevler Avinoam , Giaccia Amato J. , Woodward Wendy A.
Published: February 2019

The development of cancer and their response to radiation are intricately linked to the tumor microenvironment (TME) in which they reside. Tumor cells, immune cells, and stromal cells interact with each other and are influenced by the microbiome and metabolic state of the host, and these interactions are constantly evolving. Stromal cells not only secrete extracellular matrix and participate in wound contraction, but they also secrete fibroblast growth factors(FGF) molecules, which mediate macrophage differentiation. Tumor-associated macrophages migrate to hypoxic areas and secrete vascular endothelial growth factor (VEGF) to promote angiogenesis. The microbiome and its byproducts alter the metabolic milieu by shifting the balance between glucose utilization and fatty acid oxidation, and these changes subsequently influence the immune response in the TME. Not only does radiation exert cell-autonomous effects on tumor cells, but it influences both the tumor-promoting and tumor-suppressive components in the TME. To gain a deeper understanding of how the TME influences the response to radiation, the American Society for Radiation Oncology and the American Association of Cancer Research organized a scientific workshop on July 26–27, 2018, to discuss how the microbiome, the immune response, the metabolome, and the stroma all shift the balance between radiosensitivity and radioresistance. The proceedings from this workshop are discussed here and highlight recent discoveries in the field, as well as the most important areas for future research.
Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats
Authors: Higashi Kentaro , Mori Asami , Sakamoto Kenji , Ishii Kunio , Nakahara Tsutomu
Published: February 2019

We examined the effect of probucol, an antihyperlipidemic drug with potent antioxidant properties, on cataract formation in streptozotocin (STZ)-induced hyperglycemic rats that were given 5% D-glucose as drinking water. Probucol treatment was initiated immediately after the induction of hyperglycemia was confirmed. Using full horizontal-plane lens images captured with an original digital camera system, the opacity of central region of lens was assessed by measuring the opaque area in the region. Central opacities were detected after 3 weeks of hyperglycemia, and progressed in a time-dependent manner. The majority of STZ-induced hyperglycemic rats developed severe cataracts after 9 weeks of hyperglycemia. Probucol slowed the progression of cataracts in a dose-dependent manner. Levels of sorbitol and protein carbonyls in lenses of STZ-induced hyperglycemic rats were higher than those of control rats. Probucol suppressed the increase in protein carbonyls, but not of sorbitol, in lenses of STZ-induced hyperglycemic rats. Probucol had no significant effect on increases in plasma concentrations of glucose, total cholesterol, and triglyceride observed in STZ-induced hyperglycemic rats. These results suggest that probucol slows the progression of sugar cataracts, independent of its lipid-lowering effects. The beneficial effect of probucol on cataracts is partially attributable to the attenuation of oxidative damage to lens proteins.
Genome-Wide Association Studies of Hypertension and Several Other Cardiovascular Diseases
Authors: Wang Yan , Wang Ji-Guang
Published: February 2019

Genome-wide association studies (GWAS) have greatly expanded our understanding of the genetic architecture of cardiovascular diseases in the past decade. They have revealed hundreds of suggestive genetic loci that replicate known biological candidate genes and indicate the existence of a previously unsuspected new biology relevant to cardiovascular disorders. These data have been used successfully to create genetic risk scores that may improve risk prediction and the identification of susceptive individuals. Furthermore, these GWAS-identified novel pathways may herald a new era of novel drug development and stratification of patients. In this review, we will briefly summarize the literature on the candidate genes and signals discovered by GWAS on hypertension and coronary artery disease and discuss their implications on clinical medicine.
Microvascular Retinal and Choroidal Changes in Retinal Vein Occlusion Analyzed by Two Different Optical Coherence Tomography Angiography Devices
Authors: Costanzo Eliana , Parravano Mariacristina , Gilardi Marta , Cavalleri Michele , Sacconi Riccardo , Aragona Emanuela , Varano Monica , Bandello Francesco , Querques Giuseppe
Published: February 2019

Purpose: To investigate retinal and choroidal microvascular changes and structural choroidal involvement in retinal vein occlusion (RVO). Methods: Retrospective analysis of treatment-naïve macular edema secondary to RVO, studied by optical coherence tomography (OCT) and OCT angiography (OCTA), before and after the loading phase of intravitreal injections of ranibizumab (IVR-LP). OCTA was performed using two different devices: AngioVue RTVue XR Avanti (spectral-domain OCTA) and Zeiss PLEX® Elite 9000 (swept-source OCTA). Results: 30 eyes of 30 consecutive patients (17 branch and 13 central RVO) were included. Central macular thickness and subfoveal choroidal thickness (SCT) were significantly reduced after IVR-LP (p < 0.001 and p = 0.046, respectively). 23 eyes were eligible for OCTA analysis. Baseline vessel density (VD) in deep capillary plexus (DCP) was significantly reduced in RVO eyes compared with fellow eyes (p = 0.03 and p = 0.002 for PLEX® Elite and AngioVue, respectively). After IVR-LP, no significant VD changes in any vascular layer was found. PLEX® Elite VD analysis showed significant differences in DCP between ischemic versus non-is­chemic eyes (p = 0.011). Conclusion: OCTA suggests a retinal vascular impairment of DCP but no involvement of choroid in RVO eyes. A greater baseline SCT could be due to a choroidal exudation. OCTA imaged with PLEX® Elite allowed to differentiate ischemic and non-ischemic patients at baseline.
A Study of Pap Smears in HIV-Positive and HIV-Negative Women from a Tertiary Care Center in South India
Authors: Gupta Kritika , Philipose Cheryl Sarah , Rai Sharada , Ramapuram John , Kaur Gagandeep , Kini Hema , GV Chaithra , Adiga Deepa
Published: February 2019

Objectives: The aim of this work was to study the spectrum of epithelial abnormalities on Pap smears of HIV-positive women categorized as per the Bethesda System of Reporting Cervical Cytology, to correlate them with CD4 lymphocyte counts, and to compare them with the spectrum of abnormalities seen in a HIV-negative control group. Study Design and Methodology: The present study was a 6-year retrospective study conducted in the Department of Pathology at Kasturba Medical College, Mangalore, which included 150 Pap smears from HIV-positive and HIV-negative women, respectively. The Pap-stained slides of the cases were retrieved and studied. The data collected were tabulated and analyzed. A statistical study was performed using SPSS software. The χ2 test was used to analyze the data and a p value < 0.05 was considered to be significant. Results: Pap smear abnormalities were twice as high in HIV-infected women (12%) as compared with HIV-negative women (6%; p = 0.006, RR = 2). Negative for intraepithelial lesion/malignancy was the most common finding (88%), which was further subdivided into inflammatory, atrophic smear, non-specific, candidiasis, and bacterial vaginitis groups. The percentage of epithelial abnormalities was 12%, including: atypical squamous cells of undetermined significance, 5.55%; atypical squamous cells, cannot exclude HSIL, 16.66%; low-grade squamous intraepithelial lesion, 5.55%; high-grade squamous intraepithelial lesion (HSIL), 61.11%, and squamous cell carcinoma, 11.11%. The highest incidence of intraepithelial lesions in HIV-positive females was in the age group of 34–49 years. CD4 cell counts fell in the range of 200–500 cells/mm3 in most of the HIV-positive patients (68.75%), but was not found to be statistically significant. Conclusion: Routine Pap smear examination is advocated in women with HIV as the prevalence of epithelial cell abnormalities was found to be 12%, which was twice as high as compared to the HIV-negative control group. Although there was no correlation of epithelial cell abnormalities with CD4 counts, a higher rate of the cases with epithelial abnormalities were observed to have CD4 cell counts of 200–500 cells/mm3.
Trends in Plasma Toll Fractionation for Self Sufficiency of Plasma-Derived Medicinal Products in Italy
Authors: De Angelis Vincenzo , Breda Antonio
Published: February 2019

Background and Aims: In Italy, domestic plasma toll fractionation, performed until 2014 by only one company, had limited access to different technologies and products and to price competition. In 2017, four companies acted as competitive toll fractionators for 827,720 kg of plasma. Here, we evaluate the contribution of toll manufacturing and the effects of competition on national self-sufficiency. Results: An increase in immunoglobulin production is granted by new fractionators (11–41%, in some regions adequate for self-sufficiency), although the rise in demand will still require market contribution. The decrease in albumin use (–2.6% in 2015 vs. 2014) is probably due to a better control of an impressively high demand (35.4 t in 2015). Factor VIII demand is still higher than production, but domestic plasma cannot serve as its unique source. New tenders enlarged the portfolio of products and a theoretical self-sufficiency is granted for Factor IX, prothrombin complex concentrates, antithrombin, fibrinogen, and alpha-1-antithrypsin. Conclusions: Competition among companies resulted in higher yields of albumin and immunoglobulin, decreasing their level of market dependence, an increase in the portfolio of medicines, and a decrease in price due to fractionation (20–30%), thus improving perspectives of the national program for self-sufficiency in plasma-derived medicinal products.
O processo de fruição do modificador-player no modelo de design audiovisual
Authors: Azevedo Amanda , Becker Valdecir
Published: February 2019

Este artigo analisa a transformação da fruição de conteúdos audiovisuais, que está impactando sua produção e modificando sua recepção. A propagação de conteúdos audiovisuais tem se intensificado nos últimos anos devido à disseminação de softwares de produção, modificação e distribuição, com interfaces simples e eficientes. A partir de bases fornecidas pelas áreas de interação humano-computador e estudos da audiência, este artigo usa o modelo do design audiovisual como proposta metodológica para compreender a fruição das audiências, as novas relações mediadas por softwares e, por fim, a definição sobre o papel do modificador-player nesse modelo. Os resultados apontam para o desenvolvimento de competências e habilidades dos indivíduos como fatores relevantes para a fruição de conteúdos audiovisuais.
País(es) que habito
Authors: Berjaga Méndez Rosana
Published: February 2019

O artigo apresenta uma discussão sobre o show de talentos musicais Sonando en Cuba (2015-2016) e sua tentativa de emergir como um discurso de resistência e reafirmação da nacionalidade em um contexto de globalização cultural. Reconhecido como uma das maiores produções midiáticas domésticas dos últimos anos, o programa foi lançado na conjuntura de importantes mudanças políticas e socioeconômicas que impulsionaram o reposicionamento da ilha no mapa político-cultural internacional e gerou na mídia estrangeira novas narrativas sobre a política, identidade e história da nação. Mas esse (re)aparecer no mapa simbólico ocidental também obrigou a repensar as estratégias nacionais de autorrepresentação e visibilidade para o exterior, ambos aspectos visíveis nas contraditórias narrativas geradas por Sonando en Cuba. Assim, este trabalho é um convite ao debate sobre territorialidades e representatividade, no contexto de dialogismos, coexistências e lutas das identidades nacionais na ontologia hegemônica ocidental.
Do apelo comercial ao pano de fundo da ação
Authors: Anchieta Wanderley
Published: February 2019

Neste artigo será discutido como a ideia de apelo sensório impulsionou a adoção da cor nos primeiros cinemas, especialmente em face da pressão econômica forjada pelo advento da televisão. Também serão analisadas, de forma sucinta, as primeiras tentativas de colorização (tintagens; viragens; estêncil; sistemas de duas cores, como o Kinemacolor), em cujo seio se encontrava uma disputa tecnológica entre a Europa e os EUA; a resistência dos cineastas ao emprego da cor; o triunfo do Technicolor e sua ruína; o domínio do Eastmancolor. Em seguida, comenta-se a “virada” narrativa que impeliu a função de contar histórias ao cinema, tomando o lugar das atrações como mote principal das produções. Por fim, a passagem da cor de aspecto extrínseco e comercial para função narrativa de “pano de fundo” da ação.
O papel do Twitter no agendamento jornalístico em mídia regional no Paraná
Authors: Hrenechen Vanessa Cristina de Abreu Torres , Gadini Sérgio Luiz
Published: February 2019

Este artigo discute os pressupostos da teoria do agendamento, ou agenda-setting, e busca compreender em que aspectos a rede social Twitter consegue agendar o jornal on-line Gazeta do Povo. Em seguida, o texto procura identificar os parâmetros de relevância empregados pelo jornalista ao utilizar os posts feitos no Twitter, destacando os principais valores-notícia em cada matéria. O recorte do estudo compreende o material empírico encontrado na home da Gazeta do Povo de 1º de junho de 2017 – momento em que o jornal passou a circular exclusivamente em suas plataformas digitais – ao dia 1º de agosto de 2017, compreendendo um período total de dois meses.
Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress–Gene Response
Authors: Lee Dominic Paul , Tan Wilson Lek Wen , Anene-Nzelu Chukwuemeka George , Lee Chang Jie Mick , Li Peter Yiqing , Luu Tuan Danh Anh , Chan Cheryl Xueli , Tiang Zenia , Ng Shi Ling , Huang Xingfan , Efthymios Motakis , Autio Matias I. , Jiang Jianming , Fullwood Melissa Jane , Prabhakar Shyam , Lieberman Aiden Erez , Foo Roger Sik-Yin
Published: February 2019

Background:

The human genome folds in 3 dimensions to form thousands of chromatin loops inside the nucleus, encasing genes and
cis
-regulatory elements for accurate gene expression control. Physical tethers of loops are anchored by the DNA-binding protein CTCF and the cohesin ring complex. Because heart failure is characterized by hallmark gene expression changes, it was recently reported that substantial CTCF-related chromatin reorganization underpins the myocardial stress–gene response, paralleled by chromatin domain boundary changes observed in CTCF knockout.

Methods:

We undertook an independent and orthogonal analysis of chromatin organization with mouse pressure-overload model of myocardial stress (transverse aortic constriction) and cardiomyocyte-specific knockout of
Ctcf
. We also downloaded published data sets of similar cardiac mouse models and subjected them to independent reanalysis.

Results:

We found that the cardiomyocyte chromatin architecture remains broadly stable in transverse aortic constriction hearts, whereas
Ctcf
knockout resulted in ≈99% abolition of global chromatin loops. Disease gene expression changes correlated instead with differential histone H3K27-acetylation enrichment at their respective proximal and distal interacting genomic enhancers confined within these static chromatin structures. Moreover, coregulated genes were mapped out as interconnected gene sets on the basis of their multigene 3D interactions.

Conclusions:

This work reveals a more stable genome-wide chromatin framework than previously described. Myocardial stress–gene transcription responds instead through H3K27-acetylation enhancer enrichment dynamics and gene networks of coregulation. Robust and intact CTCF looping is required for the induction of a rapid and accurate stress response.
A new Aphidius Nees (Hymenoptera, Braconidae, Aphidiinae) of Ericaphis fimbriata (Richards) (Hemiptera, Aphididae) and key to parasitoids of blueberry aphid in the Pacific Northwest
Authors: PIKE KEITH S. , STARÝ PETR , GRAF GEORGE , RAWORTH DAVID A. , MATHUR SNEH , TANIGOSHI LYNELL K. , MURRAY TODD
Published: February 2019

Aphidius ericaphidis Pike & Starý, sp. nov., is described and illustrated. This aphidiine is a parasitoid of the blueberry aphid, Ericaphis fimbriata (Richards), widely found associated with the commercial highbush blueberries, Vaccinium corymbosum L., in southwestern British Columbia, Washington, and in northeastern Oregon. It is one of several species of aphidiines known to attack E. fimbriata in North America. A key is provided to distinguish it from other parasitoid species of E. fimbriata.
A new species of Buprestis Linnaeus, 1758 from Veracruz, Mexico (Coleoptera: Buprestidae: Buprestini) and a brief discussion of the Mesoamerican species of the subgenus Knulliobuprestis Kurosawa, 1988
Authors: BELLAMY C. L.
Published: February 2019

A new species, Buprestis (Knulliobuprestis) aurora, is described from localities in the Mexican state of Veracruz and discussed in relation to B. catoxantha Gory, 1840. The following species of Buprestis are transferred to the subgenus Knulliobuprestis: B. bergevini Théry 1911, B. carabuho Westcott 1998, B. catoxantha Gory 1840 (synonyms: B. jimenezi Dugès 1891 and B. variegata Laporte & Gory 1837), B. hauseri Obenberger 1928, and B. panamensis Théry 1923 (synonym: B. panamensis var. nigripennis Théry 1934).
Description of Distolabrellus magnivulvatus sp. n. (Nematoda, Rhabditida, Mesorhabditidae) from Iberian peninsula, the second species of a rare genus
Authors: ABOLAFIA JOAQUÍN , PEÑA-SANTIAGO REYES
Published: February 2019

Distolabrellus magnivulvatus sp. n., collected from green-house soil in central Iberian peninsula, is described and illustrated. It is characterized by having 0.89–1.07 mm long body in females and 0.65–0.99 mm in males, cuticle tesselated, lateral fields with three longitudinal incisures, lip region almost continuous and 10–13 µm wide, lips dimorphic (alternately extremely reduced and ovoid), stoma 22–30 μm long or 2.0–2.8 times lip region diameter, pharyngeal collar shorter than half of total stoma length, distance to pharyngo-intestinal junction 148–190 µm, V = 82–86, vulva a transverse slit located in a vulval cone and with its anterior lip bearing a flap-like structure, body cuticle surrounding the vulva especially differentiated, female tail conical with acute tip (68–90 μm, c = 10.9–14.6, c’ = 2.1–4.5), male tail conical (23–32 μm, c = 24.8–34.0; c’ = 1.0–1.4), bursa peloderan and open anteriorly, genital papillae ten pairs (2+1/4+3), spicules 54–64 μ m long and fused two-thirds, and gubernaculum 32–41 μm long. The new taxon is the second species of the genus Distolabrellus and is compared to type species D. veechi.
Two new species of the genus Mitjaevia Dworakowska from China (Hemiptera: Cicadellidae: Typhlocybinae)
Authors: SONG YUEHUA , LI ZIZHONG , XIONG KANGNING
Published: February 2019

Two new species from China are added to the genus Mitjaevia Dworakowska, 1970 (Hemiptera: Cicadellidae: Typhlocybinae), M. protuberanta sp. n. and M. wangwushana sp. n. A key to distinguish all species of the genus is provided.
A new species of Melzerella Lima from Bolivia (Coleoptera: Cerambycidae: Lamiinae: Aerenicini) with a key to known species
Authors: WAPPES JAMES E. , LINGAFELTER STEVEN W.
Published: February 2019

A new species of Melzerella Lima is described from Santa Cruz Department, Bolivia. A key to the four known species is provided, along with color photographs documenting their vibrant patterns.
Records of phlebotomine sand flies (Diptera, Psychodidae, Phlebotominae) with a description of a new species of Sergentomyia França & Parrot from Khao Yai National Park, Thailand
Authors: CURLER GREGORY R.
Published: February 2019

Males and females of Sergentomyia phasukae sp. nov., S. bailyi (Sinton), and S. barraudi (Sinton), and females of S. gomboki (Lewis & Wharton) and Phlebotomus (Euphlebotomus) sp. (Diptera, Psychodidae, Phlebotominae) were collected by Malaise traps and CDC traps in Khao Yai National Park, central Thailand. A new species is described and illustrated, collection records for described species are given, and some taxonomic problems concerning the subgenera of Sergentomyia are discussed.
Description of the immature female stages of Ceroplastes janeirensis (Gray) (Hemiptera: Coccidae) with a special reference to the development of the wax test
Authors: DE CÁSSIA C. ROSA KEILA , PERONTI ANA LUCIA B. G. , SOUSA-SILVA CARLOS ROBERTO
Published: February 2019

This paper describes the nymphal development of Ceroplastes janeirensis (Gray), which develops its wax test differently to that currently known for other Ceroplastinae. Macroscopic and microscopic characters of the three immature female stages are described and illustrated for the first time. An identification key to the female instars is provided and a brief discussion is also included comparing their morphology with those of other Ceroplastinae.
Chinese damselflies of the genus Coenagrion (Zygoptera: Coenagrionidae)
Authors: YU XIN , BU WENJUN
Published: February 2019

We review and update species of Coenagrion recorded from China, including distributional information. A key to the males is provided including figures of the genital ligula and caudal appendages. A distributional record of Coenagrion armatum is excluded from China. Coenagrion bifurcatum Zhu & Ou-yan, 2000, is assigned as a junior synonym of Coenagrion johanssoni (Wallengren, 1894). Coenagrion chusanicum Navás, 1933 is assigned as a junior synonym of Paracercion hieroglyphicum (Brauer, 1865). Coenagrion dorothea Fraser, 1924 is newly combined as Paracercion dorothea (Fraser, 1924) comb. nov. Coenagrion impar Needham, 1930 and Cercion yunnanensis Zhu & Han, 2000 are both treated as junior synonyms of Paracercion dorothea. Coenagrion holdereri (Förster, 1900) is redescribed here based on fresh specimens.
A review of Yemmatropis (Hemiptera: Lygaeoidea: Berytidae), with descriptions of two new species from China
Authors: CAI BO , BU WENJUN
Published: February 2019

Four species of the genus Yemmatropis Hsiao, 1977, from China are treated in this paper, in which Yemmatropis erectus Henry, 2002 is newly recorded from China. Yemmatropis hsiaoi sp. nov. and Yemmatropis nigrovittatus sp. nov. are described. Photographs of head and pronotum and drawings of openings of male genital capsules and parameres of all four species, and a key to all Yemmatropis species, are provided to assist in identification. The type specimens of the new species are deposited in the Institute of Entomology, College of Life Sciences, Nankai University, Tianjin, China.
On the species identities of a complex Liolaemus fauna from the Altiplano and Atacama Desert: insights on Liolaemus stolzmanni, L. reichei, L. jamesi pachecoi, and L. poconchilensis (Squamata: Liolaemidae)
Authors: P. ROBERTO LANGSTROTH
Published: February 2019

The South American lizard genus Liolaemus has undergone a complex adaptive radiation that has resulted in the evolution of more than 200 species widely spread in an extraordinary diversity of environments, and forming a complex array of assemblages. This evolutionary complexity has puzzled systematists and taxonomists since the first species were described more than 150 years ago. Within this lineage, the Andean Liolaemus faunas have proven to be a major challenge for herpetologists. Therefore, intense research is needed in this area to clarify long-standing problems. After more than a century of taxonomic confusion, the identity of Liolaemus stolzmanni (Steindachner, 1891) is here restored as the name that must be applied to the lizards widely known as Phrynosaura (= Liolaemus) reichei Werner, 1907 from the low to midelevation deserts of Tarapacá, Chile. Since 1966, the name L. stolzmanni has been erroneously assigned to populations of Liolaemus from the high Andes of the Chile-Bolivia borderlands which, according to observations presented in this study, correspond to Liolaemus pachecoi Laurent, 1995. A lectotype and allotype for L. stolzmanni are designated and the type locality for L. stolzmanni (= L. reichei) is emended to “Deserts of Iquique, Tarapacá Region, Chile”. Furthermore, the recognition of L. pachecoi as a species distinct from L. jamesi is supported by mtDNA sequence divergence data despite the inconclusive meristic and morphometric data. In summary, I conclude that (i) the Chilean L. reichei is a synonym of L. stolzmanni, and hence, that L. stolzmanni is a species endemic to Chile, not an element of the fauna of present-day Peru and that (ii) the Chilean Altiplano populations currently recognized as L. stolzmanni are L. pachecoi, a species hitherto known only from Bolivia. Also, I report the first confirmed specimens of L. poconchilensis from Peru, a species previously known only from Chile and confused with L. reichei.
Leelumnus radium, a new genus and species of pilumnid crab from marine encrusting communities in Singapore (Crustacea: Decapoda: Brachyura: Pilumnidae)
Authors: MENDOZA JOSE CHRISTOPHER E. , NG PETER K. L.
Published: February 2019

A new genus and new species of pilumnid crab is described from marine encrusting communities in Singapore. Leelumnus gen. nov. is morphologically similar to Latopilumnus Türkay & Schuhmacher, 1985, and Aniptumnus Ng, 2002, in the general shape of the carapace, chelipeds, ambulatory legs and morphology of the male thoracic sternum, but can be distinguished by the morphologies of the front and anterolateral margin of the carapace, as well as the unique structure of the male first gonopod. Only the type species, L. radium sp. nov. is currently assigned to the new genus.
Anopheles (Cellia) rampae n. sp., alias chromosomal form K of the Oriental Maculatus Group (Diptera: Culicidae) in Southeast Asia
Authors: SOMBOON PRADYA , THONGWAT DAMRONGPAN , HARBACH RALPH E.
Published: February 2019

Chromosomal form K (also known as species K) of the Anopheles maculatus group of sibling species in the Oriental Region is diagnosed and formally named An. (Cellia) rampae Harbach & Somboon, n. sp. The male genitalia, pupa and fourth-instar larva are illustrated and information is provided on the morphology, systematics, bionomics and distribution of the species.
A review of some of the Binna-like species of Afrotropical Spilosoma Curtis (1825) listed by Goodger & Watson (1995) and including the genus Radiarctia Dubatolov (2006) (Lepidoptera: Arctiidae, Arctiinae)
Authors: HAYNES PATRICK G.
Published: February 2019

The taxonomic position of some of the Binna-like species of Afrotropical Spilosoma Curtis (1825) and Radiarctia Dubatolov (2006) are reviewed. Historical and current problems associated with determining taxa by comparison with old or faded type material are highlighted. A new genus Pseudoradiarctia is established for P. rhodesiana comb. nov., P. lentifasciata comb. nov., P. affinis comb. nov., and P. scita comb. nov. A new rank is proposed for and subspecies is described in Radiarctia screabile, and three new species are described in Pseudoradiarctia. R. screabile (Wallengren) and Binna penicillata Walker (1866) are redescribed. Lectotypes are designated for rhodesiana, lentifasciata, affinis and scita. Notes on a defence mechanism of screabile are presented.
The "false Eucoila" finally named; Striatovertex a new genus of Eucoilinae (Hymenoptera, Cynipoidea, Figitidae)
Authors: SCHICK KATHERINE N , FORSHAGE MATTIAS , NORDLANDER GÖRAN
Published: February 2019

The new genus Striatovertex is described to accomodate a distinct group of eucoiline wasps (Hymenoptera: Cynipoidea: Figitidae) currently included in the nominate genus Eucoila Westwood, but known among specialists to not belong there for decades. They are characteristically large wasps with reduced wing pubescence, parasitizing dung-breeding Diptera, and are common in North and South America, but also present in Australia and Hawaii. Their diagnostic characters place them in what is currently Ganaspini rather than very close to Eucoila in Eucoilini, and this has been confirmed by earlier phylogenetic analyses. Diagnostic and other distinctive characters are reviewed, and thirteen new combinations are made for species belonging to this group.
On the identity of Spio filicornis (O.F. Müller, 1776)—with the designation of a neotype, and the description of two new species from the North East Atlantic Ocean based on morphological and genetic studies
Authors: MEIßNER KARIN , BICK ANDREAS , BASTROP RALF
Published: February 2019

The aim of this study is to solve taxonomic problems pertaining to Spio filicornis (O.F. Müller, 1776). The original description by O. F. Müller was very brief and type material was not deposited. Based on the literature the confusion about the identity of the species has been tremendous; e.g., it was only recently realized that at least two different species from the North and Baltic Seas could be identified as S. filicornis (Bick et al. 2010). The present study is based on material collected by the authors in 2009 at the type locality in Iluilârssuk, near Paamiut, SW Greenland. Spio filicornis is redescribed in detail and illustrated comprehensively. A neotype has been designated and deposited in the collection of Rostock University. Species formerly referred to as S. cf. filicornis from the North and Baltic Seas (Bick et al. 2010) are formally described as two new species, Spio arndti sp. nov., and S. symphyta sp. nov. The morphological diagnostic characters within Spio are discussed. Information on three molecular markers (16S rDNA, 18S rDNA, cytochrome c oxidase subunit I) is also provided. The genetic divergence between the three Spio species corroborates the taxonomic discrimination.