bluuebunny/crossref_metadata_2025 huggingface dataset:
KOMUNIKASI VISUAL PADA KEMASAN BESEK MAKANAN OLEH-OLEH KHAS BANYUMAS
Authors: Lukitasari Evelyne Henny
Published: June 2022

This article discusses the bamboo baskets used for packaging traditional food from Banyumas and the meaning of the visualcommunication on the basket packaging of this food through a semiotic approach. The basket packaging is given a criticalanalysis with an interactional analysis using a semiotic approach. The interactional analysis is used to obtain a connectionbetween all the data collected using ethical research or based on the data found in the library or based on the knowledge andopinions of the researcher. The goal of the analysis of visual communication on the bamboo baskets used for packagingtraditional food from the Banyumas area is to discover the existence of the basket packaging of this food and to analyze andgain an understanding of the visual communication on the baskets used for packaging traditional food from Banyumas. Thebenefit of the analysis of visual communication on basket packaging of traditional food from Banyumas is that it will provideinformation about the visual communication on this packaging that can be used as input and as a reference for the governmentwhen determining policies regarding the packaging of traditional Banyumas food. The character of the brand element on thesix types of basket packaging of traditional Banyumas food that were studied shows the denotative meaning regardinginformation about the name of the food, the taste, the weight, the expiry date, the address of the place selling the food, as wellas other information, through the element of layout, consisting of the colour, logo, illustration, and typography. The connotativemeaning reflects the desires, hopes, and aims of the producers regarding the sale of their food.Keywords: brand, visual brand, semiotics
PENCIPTAAN KARYA TARI SLENDANG PEMALANG SEBAGAI TARI IDENTITAS KABUPATEN PEMALANG
Authors: Septimardiati Evi
Published: June 2022

The Slendang Pemalang dance was created by Koestoro in 1985. It is a form of social dance which may be performed asa solo, a duet, or by a group, and uses a scarf or slendang that is tied and used in various ways. The Slendang Pemalangdance was declared a form of regional identity in a decree by the Regent of this area on 17 September 2012. The localPemalang government subsequently adopted this dance as a form to promote its regional identity. This decision is proof thata system has the power to undertake, control, arrange, and preserve the potential expression of its regional art which isintegrated in a symbolic process. This system connects the artist, the Regent, the local government, the tourist board, and thePemalang community in a system of values of its regional identity. The performance of dance at certain ceremonies is used asa tool to display authority. The style of a dance performance as a protocolary substance and ceremony involving the Regentis a form of imaging that is used as a means of increasing the level of authority.Keywords: social dance, Pemalang identity
RUPA TOPENG KLATEN KOLEKSI BAMBANG SUWARNO
Authors: Suwasono Bening Tri
Published: June 2022

This article results from research that focuses on study how the Klaten masks. How the symbolic meanings of the Klatenmaska. How the appearce of the Klaten masks Bambang Suwarnoâ€™s collection. The aim of the research was to discover andexplain the existence of the Klaten masks, symbolic meanings, and appearce of the Klaten masks Bambang Suwarnoâ€™scollection. The method used for the study was a qualitative research method, the interaction analysis approach which wasstructured to cover a historical study, symbolic meanings, and analysis Klaten masks Bambang Suwarnoâ€™s collection (Panji,Candrakirana, Klana, Penthul, Tembem), and conclusion. The results was studied of the details as part of the masks likes eyeshape, eyebrows, nose, mouth, ornaments and other. The symbolic meanings of the Klaten masks is the connection betweenthe microcosm and macrocosm embodied in the characters and colors.Keywords: Klaten mask, symbolic meaning, characters.
TEATER TANAH IBU: MATRILINEAL DAN KUASA IDEOLOGI KAUM PEREMPUAN MINANGKABAU
Authors: - Saaduddin
Published: June 2022

theatre performance contains various ideologies that are promoted by the director as a choice of his workmanship. Thisideology can be seen in the relationship between the text of the script and the performance text. In Teater Tanah Ibu, a workby director Syuhendri, the background of Minangkabau culture is used as the centre of development for the dramatic elementsof the performance that are generated by the role of the women in the performance, and as such, the messages conveyed are fullof the ideology and the message of womenâ€™s resistance to the hegemony of Minangkabau men. This paper uses a multidisciplinaryapproach and aims to outline: (1) the process of creating Teater Tanah Ibu and (2) the form of womenâ€™s ideologyfound in Teater Tanah Ibu. The observation showed that the ideology of Minangkabau women in Teater Tanah Ibu was bornas the dialectic of women in understanding a migrant culture that reflects womenâ€™s ideology.Keywords: Teater Tanah Ibu, Ideology, Women
On İki İmam Şiîliği’nde Veliyy-i Fakih’in Adâlet Sıfatı
Authors: BİÇEN Gürkan , İSKENDEROĞLU Muammer
Published: June 2022

İnsanın toplum ve devletle olan ilişkisinde aranan dengeyi ifade eden adâlet kavramına dair tartışma insanlık tarihi kadar eskidir. Hemen her dünya görüşü adâlete dair bir açıklama getirmiş ve adâleti insan ve toplum hayatının temeline yerleştirmiştir. Adâletin tümüyle sağlanması halinde insan ve toplumun barış içinde yaşayabileceği aksi halde her birinin fesada sürükleneceği söylenmiştir. Adâletin ne olduğuna dair tartışmanın yanında adâleti kimin sağlayabileceğine dair bir başka tartışma da kadim medeniyetlerden günümüze dek kesintisiz bir biçimde her zaman süregelmiştir. Antik Yunan'dan sonra İslam medeniyeti de bu konuya önem vermiş, sistemli ve bütüncül çalışmalar yaratmıştır. Bu bağlamda, adâlete ve onu kimin icra edebileceğine dair açıklama getiren görüşlerden biri de On İki İmam Şiiliği’dir. On İki İmam Şiiliği velâyet kavramıyla sıkı sıkıya bağlı gördüğü adâlet kavramına özel bir önem vermiştir. Siyasal düzlemde ise İmamlara benzemesi sebebiyle adâleti ancak fakihin sağlayabileceği ileri sürülmüştür. Bu da fakihin siyasi irade ve kudretin somut aktörlerinden birisi olmasının yolunu açmıştır, hâl böyle olunca, toplumun yönetimini ele alması umulan fakihte aranan iki temel şarttan biri de adâlet olmuştur. Bu makale, On İki İmam Şiiliği’nin Veliyy-i fakih’te aradığı adâlet sıfatını, tarihi izlekte adâlet kavramını felsefi, kelami ve fıkhi boyutlarıyla ve mümkün olduğunca birincil kaynaklara dayanarak ele almaktadır. Ayrıca anayasal düzeyde hukuki, siyasi ve dini konuma sahip Veliyy-i fakih idaresiyle yönetilen İran İslam Cumhuriyeti tecrübesini de bu yönüyle incelemeyi amaçlamaktadır.
International Listening Posts global report summary: the world at the dawn of 2021
Authors: O’Byrne-Maguire Irene , Beland Ulrike , Stuart Rob , Maguire Bryan , Wujec Kamila , Vonofakos Dimitrios
Published: June 2022

From 2019, the novel coronavirus or “Covid-19” spread around the globe, bringing death and disruption. On or around 8 January 2021 thirty-six Listening Posts were conducted in twenty-three countries: Australia, Argentina, Brazil, Bulgaria, Canada, China, Denmark, Faroe Islands, Finland, Germany, India (11 regions in one combined report), Ireland, Israel, Italy (4 LPs), Lithuania, Netherlands, Poland, Serbia, South Africa, Taiwan, Turkey, United Kingdom, United States of America. This global report synthesises twenty-two local reports, extracts general themes and patterns, and offers connections and interpretations. For the first time International Listening Posts were conducted online.
The American Adam—caught between the myth of innocence and the guilt of perpetration
Authors: West-Leuer Beate
Published: June 2022

The collective sense of male identity in the US is founded on a mythic hero that has permeated American literature since the nineteenth century: the American Adam. He is an innocent outsider, living free to conquer the “Wild West” within or—with the loss of the geographical frontier—beyond the national borders of the United States. Through the military machine, a man can release himself from the demands of society and recreate his sense of innocent masculinity. This male ego ideal con-tinues to be influential as the guiding principle for the political leadership of the USA. This is exemplified by psychoanalysing a documentary film about a Vietnam veteran and by an in-depth comparison of the “Adamic” quality of two recent presidents with two of Melville’s literary protagonists: Billy Budd and the Confidence-Man.
“Why do I have to do this? And why not?” Institutions, integrity, and citizenship under threat
Authors: Triest Joseph (Yossi)
Published: June 2022

Ed Shapiro’s important and thought-provoking article deals with civic ethics and is organised around three critical points: a call (1) for taking personal authority in order to protect the group from (what is perceived as) its destructors (Why do I have to do this?); an offer for (2) doing it by being emphatic with the “enemy” (in what way is he right?); and (3) encouragement to reveal “active citizenship”.
The discussion challenges those questions by asking: Do I have to do this?Always? And why me? Do I have to understand the other? Always? Under what conditions? And is it really possible, taking into account our unconscious attitudes towards “otherness”? The discussion refers to the timing and the sociopolitical con-text of Shapiro’s article—namely turbulent times and a deep disappointment of present-day leadership—and interprets his challenge as a call for the return of the individual almost as a “Nietzschean hero”—namely, to differentiate him/herself even from the group-as-a-whole. Some unconscious aspects of the challenge which Ed Shapiro puts before us are discussed, referring to the inherent tension between “what should be” and “what is actually happening”.
Ed Shapiro responds
Authors: Shapiro Edward R.
Published: June 2022

In response to Dr Triest’s discussion of his article, Dr Shapiro focuses on the way polarised relationships might be integrated in the process of joining an institutional mission. Any effort to listen across polarisation (“How are they right?”) requires con-tainment of aggression and the discovery of a shared task, a third perspective to the dyad in opposition. Dr Shapiro offers, as an example of listening across polarisation, his own effort as an American citizen to find himself in Donald Trump.
Is there a doctor in the house? Systems-psychodynamic research into general practitioners’ experiences of changes in healthcare delivery
Authors: Greenway Elizabeth
Published: June 2022

My qualitative research uses a psychosocial approach to explore GPs’ experiences during changes in healthcare delivery prior to the impact of the Covid-19 pandemic. The challenges of running everyday general practice under the neoliberal paradigm meant that GPs were retiring early, and that new GPs were hard to recruit. Even before March 2020, the biopsychosocial model of medicine was contending with many complexities, including workforce shortages, an ageing population, increas-ing incidence of chronic comorbidity, and the development of clinical technologies, to name but a few. General practice is also challenged by the requirements of com-missioning, bidding, and contracting in order to sustain income and viability. What defines GPs’ primary tasks, roles, and systems, and how are GPs’ motivations and identities affected by this situation of clinical complexity and financial challenge? My research reveals three types of GP and an ecosystem’s model of the organisation-in-the-mind, involving various social defences and valencies for individual and group functioning.
Managing accelerating complexity and inter-group conflict in the care of critically ill children
Authors: Frugé Ernest , Sprehe Michael , Brown-Hellsten Melody , Loftis Laura
Published: June 2022

Modern medical care for critically ill children meets the definition of a Volatile, Uncertain, Complex, and Ambiguous (VUCA) situation with an additional “R” factor of high risk (suffering and potential death of a child). The circumstances of care for a critically ill child create a unique psychological, social, and technical crucible for all involved, one primed for conflict. This article will trace the evolution of our study of inter-group conflict between physicians in the care of critically ill children from initial observations to broad, systematic surveys and qualitative analysis of practitioner focus groups. Our findings indicated that unconscious inter-group dynamics, shaped by setting variables, can significantly impair collective work towards the best interests of patients in these fraught circumstances, making “integrative deci-sion-making” difficult to achieve. Patterns in inter-group relations clearly suggested the use of splitting as a social defence. The findings and related hypotheses pro-vided clues for strategies to mitigate the impact of these dynamics. This article con-cludes with a description of the design and pilot testing of a structured method of case review designed to provide containing structures tuned to the specific context with the ultimate aim of facilitating integrative decision-making and optimising co-ordination of care for complex cases.
The Validity of the Discovery Learning Model to Improve Students Creative Thinking Skills
Authors: Kari Dwi Septia , Ayub Syahrial , Verawati Ni Nyoman Sri Putu
Published: June 2022

This study aims to determine the validity of the product in the form of learning tools based on discovery learning models to improve creative thingking skills of students on momentum and impulse material. The type of research that used in this research is R&D (Research and Development) with a 4D model namely define, design, develop and disseminate. The products develop are syllabus, Learning implementation plan, teaching materials, Student worksheet and creative thingking ability test instruments. Validity data was obtained from the results of filling out the validation sheet by six validators, namely three expert validators and three practitioner validators. The validation sheets is filling by likert scale of 1-4. The percentage of validity results by expert validators has an average value of 84.82% with a fairly valid category. And the results of the validity value by the practitioner validators have an average value of 94.12% with a very valid category. The result of this study indicate that learning devices based on discovery learning models to improve students creative thinking skills are valid for use in learning at school.
Development of Augmented Reality-Based Interactive “Element Card” Media on Electron Configuration Submaterial According to Niels Bohr
Authors: Qibtiyah Mariatul , Sukarmin Sukarmin
Published: June 2022

This study aims to obtain the feasibility of Augmented Reality-based Element Card interactive media on the electron configuration submaterial according to Bohr's theory. This research uses a 4D model which is only carried out until the development stage. This research was conducted at SMAN 1 Gedangan Sidoarjo on 30 students X IPA. This study used a validation sheet instrument, pretest and posttest questions, student response questionnaires, and student observation questionnaires. If the value of the validation result is ≥ 61% then it is considered valid, the practicality value is ≥ 61% then it is considered practical, and the effectiveness value if it is classified above 0.3 which includes medium or high then it is considered effective. The results of content and construct validation are 88% and 84% are included in the very valid category. Practicality was obtained from 94.86% and 97% of student responses and observations included in the very practical. The effectiveness is obtained from learning outcomes by calculating the N-Gain and Wilcoxon Signed Ranks Test, the value of Asymp. Sig (2 tailed) is 0.000 which is smaller than 0.05 so there is a difference in the students' pretest and posttest scores. This proves that the interactive media based on the Augmented Reality Element Card can be used for chemistry learning media.
Direct Current (DC) vs Alternating Current (AC) Financial Transaction Flow in Holding and Non-Holding Companies
Authors: Fikri M. Ali , Inapty Biana Adha , Astuti Baiq Rosyida Dwi
Published: June 2022

A study on the flow of financial transactions needs to be carried out considering that activities in the financial sector require quick and relevant decisions. The flow of financial transactions in the business world is almost similar to direct current (DC) and alternating current (AC). The phenomenon is that many business people want their funds to be spread outside the company, and some want their funds to only revolve around the company. This study tries to analyze the results of investment flows of funds outside the company and within the company in the scope of the Indonesian capital market. This research is a research using a descriptive approach. The descriptive approach is intended to describe phenomena that occur in the field. The number of sample companies is 175 companies (holding and non-holding). Each company is given a code (code 1 for holding, and code 0 for non-holding), and company data is screened according to research needs on aspects; profit return, stock return, stock price, and profit and loss. Data mining in the field is carried out by researchers by means of secondary data analysis techniques for the capital market through analysis of financial statements from the side of the transaction flow. Then the results of the analysis of the company's flow of funds are processed, compared, and used as the basis for drawing conclusions. The results provide evidence that holding financial flows are more profitable than non-holding according to AC/DC transaction flows. This is in accordance with the risk reduction theory that many developed countries do by controlling the circulation of money only around their country. Theoretically, the results of this study contribute that holding companies have advantages over non-holdings, and practically this research provides a discourse for business people that it is better to run the business alone and not depend on outside parties.
KAJIAN PENGARUH AKTIVITAS INDUSTRI TERHADAP TINGKAT PENCEMARAN AIR LAUT DI KOTA SORONG
Authors: Histiarini Aprisa Rian , Yakin Kamal
Published: June 2022

Aktivitas industri yang ada pada wilayah pesisir memunculkan pencemaran laut di masa sekarang dan untuk mengetahui seberapa besar tingkatan pencemaran air laut oleh limbah dari aktivitas industri yang ada di Kota Sorong. Sedangkan tujuan penelitian untuk mengetahui sejauh mana tingkat pencemaran laut akibat aktivitas industri yang ada di wilayah pesisir Kota Sorong. Berdasarkan hasil pengamatan menyebutkan bahwa Pada stasiun I yang berlokasi di Kali Remu menunjukkan skor -60 dengan parameter yang berpengaruh yaitu Ammonia, Asam Sulfat , dan COD (Chemical Oxygen Demand) yang melewati ambang batas dari baku mutu. dengan gejala tercemar berat. Pada Stasiun II yaitu bertempat di Tempat Pelelangan ikan (TPI) di Jembatan Puri, Kelurahan Klaligi diperoleh skor -40 dengan parameter yang berpengaruh yaitu Ammonia, dan Asam Sulfat. Pada Stasiun III yang bertempat di Pelabuhan Perikanan diperoleh skor -60 dengan parameter yang berpengaruh yaitu Amoniak, COD, dan Oksigen terlarut. Sedangkan pada Stasiun IV diperoleh skor 0, dan bermakna belum menunjukkan tanda-tanda pencemaran yang memberikan pengaruhi bagi kualitas air di wilayah pesisir Kota Sorong, 3 dari 4 stasiun pengamatan menunjukkan gejala tercemar berat dengan Skor yaitu -40 hingga -60. Aktivitas industri di Kota Sorong memunculkan pencemaran di masa sekarang dan kategori pencemaran tersebut tergolong ke dalam Kelas D yaitu buruk dan tercemar berat. Kategori tercemar berat ditemukan di Stasiun 1 yaitu di kali remu, ST2 yaitu Tempat Pelelangan ikan di Jembatan Puri, Kelurahan Klaligi, dan ST3 yaitu perairan pesisir Pelabuhan Perikanan. Sedangkan ST4 menunjukkan belum ada tanda-tanda pencemaran yang memberikan pengaruhi bagi kualitas air di wilayah pesisir Kota Sorong.
Perbaikan Kualitas Bahan Baku Noken Kain Rumput Pada Sanggar Emeyedore Dengan Metode Palda
Authors: Masniar Masniar , Amri Irman , Awola Steven
Published: June 2022

Noken kain rumput merupakan karya seni yang berasal dari suku kokoda yang di kelola oleh sanggar emeyedore yang memanfaatkan daun pucuk sagu sebagai bahan pembuatan noken kain rumput. Namun saat proses merajut terdapat serat noken yang terputus. Tujuan dari penelitian ini untuk mengetahui faktor_faktor yang menyebabkan serat noken terputus saat proses merajut dan untuk mengetahui apakah dengan pendekatan palda ada perubahan pada kualitas bahan baku. Metode yang digunakan dalam penelitian ini adalah model palda merupakan suatu konsep model analisis perbaikan mutu untuk GKM yang menuntut pelepasan dari kondisi manajemen tradisional menjadi kondisi manajemen industry yang di sesuaikan dengan kondisi IKM (industry kecil menengah) dalam strata paling bawah. Model palda adalah model gugus yang melakukan pemecahan masalah peningkatan mutu berpola manajemenâ€PDCAâ€ dengan cara menggunakan daya NPK (naluri, pengalaman, keulatan) dengan empat langkah dan dua alat. kesimpulan dari penelitian ini penyebab terjadinya bahan noken mudah putus saat proses merajut adalah Manusia yang terlalu lama dalam mengucak bahan baku, Material yang dihasilkan terlalu halus, Alat pengukur suhu tidak ada, Metode penjemuran tidak digantung dan terurai, Lingkungan penjemuran suhu panas. Dari hasil pelaksanaan perbaikan menggunakan metode palda data yang diperoleh jumlah serat yang terputus ada 7 serat, dibandingkan dengan data sebelum perbaikan jumlah serat yang terputus 50 serat. bahan noken sudah berkualitas karena bahan yang digunakan lebih kasar dan kuat sehingga bahan noken tidak mudah putus.
ANALISIS STRATEGI PEMASARAN USAHA UMKM KRIPIK SINGKONG MENGGUNAKAN METODE SWOT
Authors: Masniar Masniar , Histiarini Aprisa Rian , Sucipto Ari Nur
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui kekuatan, kelemahan, peluang, ancaman, untuk menyususn IFAS (Internal Factor Analysis Summer) dan EFAS (Eksternal Factor Analysis Summer) dan untuk mengetahui strategi pemasaran pada Usaha Kripik Singkong Mbak Rini setelah di analisis dengan SWOT (Strength, Weakness, Opportunity, Threat). Fenomena yang ada usaha tersebut menghadapi persaingan yang ketat ditandai dengan adanya usaha-usaha sejenis. Penelitian ini menggunakan medotode analis SWOT yaitu analisis yang mengidentifikasi faktor internal dan faktor eksternal usaha. Data dikumpulkan melalui observasi, wawancara dan pembagian kuesioner kepada masyarakat Aimas Kabupaten Sorong yang berjumblah 100 orang. Hasil penelitian tersebut menunjukan nilai sebagai berikut: (1) hasil analisis IFAS adalah sebesar 7,00 dimana faktor yang paling kuat pada internal usaha adalah kelemahan pada desain kemasan. (2) Hasil analisis EFAS diperoleh skor 7,00 dimana faktor yang paling kuat pada eksternal usaha adalah peluang perusahaan artinya perlu mengoptimalkan peluang untuk meminimalisir ancaman yang ada. (3) hasil Matriks IE menunjukan posisi Usaha Kripik Singkong Mbak Rini saat ini berada pada Kuadran IV pada posisi ini produk tersebut masih mempunyai peluang untuk mengatasi ancaman. Strategi yang harus diterapkan dalam kondisi ini adalah memperbaiki produk untuk mengoptimalkan pluang dan meminimalisis ancaman.
Isıl işlem görmüş Hindistan cevizi odununda bazı yüzey özelliklerinin incelenmesi
Authors: AYATA Ümit
Published: June 2022

Bu çalışmada, Hindistan cevizi (Cocos nucifera L.) ahşabına uygulanmış olan 200oC’de 3 saat süre ile yapılan ısıl işlem sonrasında meydana gelen bazı yüzey özellikleri [renk (∆L*, ∆b*, ∆a*, L*, b*, a*, ∆C*, ∆E*, C* ve ho), parlaklık (20o, 60o ve 85o’de liflere paralel (║) ve dik (⊥)) ve shore D sertlik] araştırılmıştır. Buna ek olarak, ısıl işlemsiz örneklerde de farklı numaralı zımparaların uygulanması sonrasında meydana gelen yüzeylerdeki değişiklikler de belirlenmiştir. Araştırma sonuçlarına göre, ısıl işlem sonrasında shore D sertlik değerinin, 20o, 60o ve 85o’de liflere paralel ve dik parlaklık değerlerinin ile L*, a*, b*, C* parametrelerinin azaldığı ve ho açısının ise arttığı belirlenmiş, buna ek olarak; ∆H*: 13.87, ∆L*: -14.21, ∆b*: 18.40, ∆a*: -7.93, ∆C*: -14.45 ve ∆E*: 24.57 olarak elde edilmiştir. Yüzey pürüzlülüğü sonuçlarında ise Ra parametre değerleri 80, 100, 120, 150, 180 ve 220 numaralı zımparalarda sırası ile 8.498 µm, 7.429 µm, 6.600 µm, 5.332 µm, 4.188 µm ve 3.452 µm olarak bulunmuştur. Zımpara numarasının artması ile pürüzlülük parametrelerinin azaldığı tespit edilmiştir.
The Effect of Corporate Governance and Company Size on Tax Avoidance
Authors: Srimindarti Ceacilia , Widyaningsih Cici Andriani , Oktaviani Rachmawati Meita , Hardiningsih Pancawati
Published: June 2022

Purpose – This study aims to examine the effect of corporate governance and company size on tax avoidance in manufacturing companies.

Methodology – The population includes all the manufacturing companies listed on the Indonesia Stock Exchange during 2017-2019 and the 288 companies used as samples were selected through the purposive sampling method. A regression model was used for analysis.

Findings – The results showed that institutional ownership, independent commissioners, and audit committee did not affect tax avoidance but managerial ownership and firm size have some influence. It was recommended that companies improve good governance by reducing their tax avoidance policies while other variables such as audit quality, executive character, liquidity, accounting conservatism, and capital intensity are suggested to be added to further studies related to tax avoidance.

Originality – The novelty of this study is examine all corporate governance mechanisms consist of institutional ownership, independent commissioner, audit committee, and managerial share ownership on tax avoidance.
Optimization of Financial Satisfaction: Stimulant from Financial Literation and Inclusion for Society
Authors: Yuliani Yuliani , Taufik Taufik , Fuadah Luk Luk , Andriyani Ima
Published: June 2022

Purpose - The study aims to develop a theoretical model of financial satisfaction and an empirical research model on literacy and inclusion. Primarily, it aims to analyze the concepts of financial attitude, behavior, and knowledge. 

Methodology - Data were obtained from individuals at Palembang City South Sumatera in between the ages of 20 and 55 who earned an income were included in this research. Furthermore, the Structural Equation Modeling (SEM) technique was used to obtain data of non-probability 142 respondents between May and July 2019.

Findings - The results showed that financial attitude and knowledge have a significant positive effect on literacy, while financial behavior shows insignificant impact on literacy. Financial literacy has a significant positive effect on inclusion and satisfaction. Meanwhile, financial inclusion has no significant impact on satisfaction.

Originality - This research develops an empirical model of financial satisfaction by examining in detail how individuals increase the availability of products and services, including the ease of access.
Liten ändring gav stor effekt på lärande om teoriers särdrag
Authors: Lunde Torodd
Published: June 2022

När lärare började jämföra naturvetenskapliga och pseudovetenskapliga teorier mer systematiskt och sammanhållet blev det lättare för eleverna att urskilja vilka skillnader som är väsentliga och varför. Relativt små ändringar i hur lärare presenterade jämförelsen kunde ha stor betydelse för elevernas lärande. Det visar en studie från Malmö universitet.
En bredd av utgångspunkter för dialog
Authors: Höst Gunnar , Lunde Torodd
Published: June 2022

I det här numret presenterar vi texter som spänner över många utbildningsnivåer och typer av innehåll. Flera av texterna handlar om laborativ undervisning, och vi relaterar dessa till den systematiska översikt som Skolforskningsinstitutet presenterat om detta forskningsområde. Numret tar också upp olika former av kommunikation i klassrummet, forskning om yngre barns lärande och undervisning om tekniska system.
Identification of LncRNA CARD8-AS1 as a Potential Prognostic Biomarker Associated With Progression of Lung Adenocarcinoma
Authors: Ji Yong , Zhang Guoqing , Zhang Xingyi
Published: June 2022

Introduction: Long non-coding RNAs (lncRNAs) exhibit crucial roles in human tumors. However, the role of lncRNA CARD8-AS1 in lung adenocarcinoma remains elusive. This study investigated the role of CARD8-AS1 in lung adenocarcinoma.

Materials and Methods: The expression of CARD8-AS1 was detected by RT-qPCR analysis and confirmed using an online database. The clinical value of CARD8-AS1 was evaluated using the Kaplan-Meier curve and multivariate Cox regression analyses. The effects of CARD8-AS1 on cancer cell proliferation, migration, and invasion potential were assessed through several cellular experiments. Western blot assay was used to measure Bcl-2 and Bax protein levels. The interaction among CARD8-AS1, miR-650, and Bax, was assessed using a dual-luciferase reporter assay.

Results: The expression of CARD8-AS1 was decreased in lung adenocarcinoma tissues and cell lines (p < 0.001). Low expression of CARD8-AS1 was related to tumor size (p = 0.042), TNM stage (p = 0.021), lymph node metastasis (p = 0.025), and poor overall survival (p < 0.05). Elevated expression of CARD8-AS1 could suppress cellular viability, migration potential, and invasion ability (p < 0.05). The Bcl-2 protein levels were decreased while Bax levels were increased by overexpression of CARD8-AS1 (p < 0.001). miR-650 may thus be a direct target of CARD8-AS1 and Bax may be a direct target of miR-650.

Discussion: CARD8-AS1 expression was downregulated in lung adenocarcinoma and associated with several clinical parameters. CARD8-AS1 exerted tumor-suppressive effects by targeting the miR-650 and then regulating Bax expression. CARD8-AS1/miR-650 may serve as novel prognostic biomarkers and potential therapeutic targets for the treatment of lung adenocarcinoma.
FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability
Authors: Dibus Nikol , Korinek Vladimir , Cermak Lukas
Published: June 2022

Alterations in the gene encoding the E3 ubiquitin ligase substrate receptor FBXO38 have been associated with several diseases, including early-onset motor neuronopathy. However, the cellular processes affected by the enzymatic action of FBXO38 are not yet known. Here, we identify the zinc finger proteins ZXDA/B as its interaction partners. FBXO38 controls the stability of ZXDA/B proteins via ubiquitination and proteasome-dependent degradation. We show that ZXDA/B proteins associate with the centromeric protein CENP-B and that the interaction between ZXDA/B and FBXO38 or CENP-B is mutually exclusive. Functionally, ZXDA/B factors control the protein level of chromatin-associated CENP-B. Furthermore, their inappropriate stabilization leads to upregulation of CENP-A and CENP-B positive centromeric chromatin. Thus we demonstrate a previously unknown role of cullin-dependent protein degradation in the control of centromeric chromatin integrity.
Neutrophil Extracellular Traps Induced by Shiga Toxin and Lipopolysaccharide-Treated Platelets Exacerbate Endothelial Cell Damage
Authors: Landoni Verónica Inés , Pittaluga Jose R. , Carestia Agostina , Castillo Luis Alejandro , Nebel Marcelo de Campos , Martire-Greco Daiana , Birnberg-Weiss Federico , Schattner Mirta , Schierloh Pablo , Fernández Gabriela C.
Published: June 2022

Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in the pediatric population. The etiology of HUS is linked to Gram-negative, Shiga toxin (Stx)-producing enterohemorrhagic bacterial infections. While the effect of Stx is focused on endothelial damage of renal glomerulus, cytokines induced by Stx or bacterial lipopolysaccharide (LPS) and polymorphonuclear cells (PMNs) are involved in the development of the disease. PMN release neutrophil extracellular traps (NETs) to eliminate pathogens, although NETs favor platelets (Plts) adhesion/thrombus formation and can cause tissue damage within blood vessels. Since thrombus formation and occlusion of vessels are characteristic of HUS, PMN–Plts interaction in the context of Stx may promote netosis and contribute to the endothelial damage observed in HUS. The aim of this study was to determine the relevance of netosis induced by Stx in the context of LPS-sensitized Plts on endothelial damage. We observed that Stx2 induced a marked enhancement of netosis promoted by Plts after LPS stimulation. Several factors seemed to promote this phenomenon. Stx2 itself increased the expression of its receptor on Plts, increasing toxin binding. Stx2 also increased LPS binding to Plts. Moreover, Stx2 amplified LPS induced P-selectin expression on Plts and mixed PMN–Plts aggregates formation, which led to activation of PMN enhancing dramatically NETs formation. Finally, experiments revealed that endothelial cell damage mediated by PMN in the context of Plts treated with LPS and Stx2 was decreased when NETs were disrupted or when mixed aggregate formation was impeded using an anti-P-selectin antibody. Using a murine model of HUS, systemic endothelial damage/dysfunction was decreased when NETs were disrupted, or when Plts were depleted, indicating that the promotion of netosis by Plts in the context of LPS and Stx2 plays a fundamental role in endothelial toxicity. These results provide insights for the first time into the pivotal role of Plts as enhancers of endothelial damage through NETs promotion in the context of Stx and LPS. Consequently, therapies designed to reduce either the formation of PMN–Plts aggregates or NETs formation could lessen the consequences of endothelial damage in HUS.
Research on the Mechanism and Prevention of Hypertension Caused by Apatinib Through the RhoA/ROCK Signaling Pathway in a Mouse Model of Gastric Cancer
Authors: Wang Wenjuan , Li Caie , Zhuang Chenchen , Zhang Haodong , Wang Qiongying , Fan Xin , Qi Miaomiao , Sun Runmin , Yu Jing
Published: June 2022

Hypertension is one of the main adverse effects of antiangiogenic tumor drugs and thus limits their application. The mechanism of hypertension caused by tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factors is mainly related to inhibition of the nitric oxide (NO) pathway and activation of the endothelin pathway, as well as vascular rarefaction and increased salt sensitivity; consequently, prevention and treatment differ for this type of hypertension compared with primary hypertension. Apatinib is a highly selective TKI approved in China for the treatment of advanced or metastatic gastric cancer. The RhoA/ROCK pathway is involved in the pathogenesis of hypertension and mediates smooth muscle contraction, eNOS inhibition, endothelial dysfunction and vascular remodeling. In this study, in vivo experiments were performed to explore whether the RhoA/ROCK signaling pathway is part of a possible mechanism of apatinib in the treatment of gastric cancer-induced hypertension and the impairment of vascular remodeling and left ventricular function. Y27632, a selective small inhibitor of both ROCK1 and ROCK2, was combined with apatinib, and its efficacy was evaluated, wherein it can reduce hypertension induced by apatinib treatment in gastric cancer mice and weaken the activation of the RhoA/ROCK pathway by apatinib and a high-salt diet (HSD). Furthermore, Y-27632 improved aortic remodeling, fibrosis, endothelial dysfunction, superior mesenteric artery endothelial injury, left ventricular dysfunction and cardiac fibrosis in mice by weakening the activation of the RhoA/ROCK pathway. The expression of RhoA/ROCK pathway-related proteins and relative mRNA levels in mice after apatinib intervention were analyzed by various methods, and blood pressure and cardiac function indexes were compared. Endothelial and cardiac function and collagen levels in the aorta were also measured to assess vascular and cardiac fibrosis and to provide a basis for the prevention and treatment of this type of hypertension.
Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction?
Authors: Stadiotti Ilaria , Santoro Rosaria , Scopece Alessandro , Pirola Sergio , Guarino Anna , Polvani Gianluca , Maione Angela Serena , Ascione Flora , Li Qingsen , Delia Domenico , Foiani Marco , Pompilio Giulio , Sommariva Elena
Published: June 2022

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome characterized by impaired left ventricular (LV) diastolic function, with normal LV ejection fraction. Aortic valve stenosis can cause an HFpEF-like syndrome by inducing sustained pressure overload (PO) and cardiac remodeling, as cardiomyocyte (CM) hypertrophy and fibrotic matrix deposition. Recently, in vivo studies linked PO maladaptive myocardial changes and DNA damage response (DDR) activation: DDR-persistent activation contributes to mouse CM hypertrophy and inflammation, promoting tissue remodeling, and HF. Despite the wide acknowledgment of the pivotal role of the stromal compartment in the fibrotic response to PO, the possible effects of DDR-persistent activation in cardiac stromal cell (C-MSC) are still unknown. Finally, this novel mechanism was not verified in human samples. This study aims to unravel the effects of PO-induced DDR on human C-MSC phenotypes. Human LV septum samples collected from severe aortic stenosis with HFpEF-like syndrome patients undergoing aortic valve surgery and healthy controls (HCs) were used both for histological tissue analyses and C-MSC isolation. PO-induced mechanical stimuli were simulated in vitro by cyclic unidirectional stretch. Interestingly, HFpEF tissue samples revealed DNA damage both in CM and C-MSC. DDR-activation markers γH2AX, pCHK1, and pCHK2 were expressed at higher levels in HFpEF total tissue than in HC. Primary C-MSC isolated from HFpEF and HC subjects and expanded in vitro confirmed the increased γH2AX and phosphorylated checkpoint protein expression, suggesting a persistent DDR response, in parallel with a higher expression of pro-fibrotic and pro-inflammatory factors respect to HC cells, hinting to a DDR-driven remodeling of HFpEF C-MSC. Pressure overload was simulated in vitro, and persistent activation of the CHK1 axis was induced in response to in vitro mechanical stretching, which also increased C-MSC secreted pro-inflammatory and pro-fibrotic molecules. Finally, fibrosis markers were reverted by the treatment with a CHK1/ATR pathway inhibitor, confirming a cause-effect relationship. In conclusion we demonstrated that, in severe aortic stenosis with HFpEF-like syndrome patients, PO induces DDR-persistent activation not only in CM but also in C-MSC. In C-MSC, DDR activation leads to inflammation and fibrosis, which can be prevented by specific DDR targeting.
Case Report: Unusual Cause of Chest Pain: A Multi-Image Assessment of a Cardiac Mass
Authors: Serrano-Roman Javier , Saenz-Ancira Santiago , Armendariz-Ferrari Jose C. , Fernandez-Badillo Valente , Solorzano-Pinot Enrique , Espejel-Guzman Adrian , Berarducci Joaquin , Aranda-Fraustro Alberto , Garcia-Cardenas Mauricio , Espinola-Zavaleta Nilda
Published: June 2022

Myxomas represent the most common benign primary cardiac tumor, they usually grow out of the interatrial septum into the left atrium with a pedunculated base. Intracardiac masses can be found incidentally on imaging studies, but symptomatology may arise secondary to the mass effect, embolization, and valvular function impairment. We present the case of a 75-year-old woman who arrived at the emergency department with atrial fibrillation and NSTEMI segment elevation myocardial infarction (NSTEMI) secondary to a highly vascularized neoplasm visible by coronary angiography and angiotomography. Scarce reports show high quality multi-imaging assessment of significantly vascularized myxomas with such atypical presentation. High-definition imaging studies played a fundamental role in the surgeon’s management of a mass with a complex neovascularization.
Prognostic Value of Metabolic Syndrome in Patients With Non-ST Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Authors: Zhao Li-Hong , Liu Yin , Xiao Jian-Yong , Wang Ji-Xiang , Li Xiao-Wei , Cui Zhuang , Gao Jing
Published: June 2022

Objective

We aim to investigate the prognostic effects of metabolic syndrome (MS) on patients with non-ST elevated myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI).

Methods

Patients with NSTEMI undergoing PCI were consecutively collected. According to the presence or absence of MS, they were divided into two groups and followed up for 1 year. The endpoint was major adverse cardiovascular events (MACE), including all-cause death, unstable angina hospitalization, heart failure (HF) hospitalization, non-fatal recurrent myocardial infarction (MI), and target lesion revascularization. Also, six subgroups were made according to gender, age, left ventricular ejection fraction (LVEF), Global Registry of Acute Coronary Events (GRACE) score, hypersensitive troponin (hsTNT), and several diseased vessels. Cox proportional hazard model was adopted to analyze the effect of MS on MACE in all the patients and different subgroups.

Results

A total of 1,295 patients were included in the current analysis and 660 (50.97%) of them had MS. About 88 patients were lost to follow-up, and the overall average follow-up was 315 days. MS was an independent risk factor for MACE (HR 1.714, CI 1.265–2.322, p = 0.001), all-cause death, heart failure (HF) hospitalization, and non-fatal recurrent MI. In the MS component, BMI ≥28 kg/m2 was positively associated with MACE. Subgroup analysis indicated the prognostic value of MS was more striking for patients with the following: age of >60, LVEF of ≤40%, GRACE of >140, multivessel disease, or hsTNT of >0.1 ng/ml.

Conclusions

The MS was a robust adverse prognostic factor in patients diagnosed with NSTEMI, especially among those of older age and at higher ischemic risk. A BMI of ≥28 kg/m2 independently predicted the occurrence of MACE. Prognosis may be improved by controlling abdominal obesity.
Case Report: A Rare Abdominopelvic Arteriovenous Malformation: Originating From Splenic Artery and Draining Into Portal Vein
Authors: Li Xin , Li Jiehua , Wang Mo , Wang Junwei , Wang Lunchang , He Hao , Li Ming , Li Quanming , Shu Chang
Published: June 2022

Background

Abdominopelvic arteriovenous malformation is an uncommon congenital vascular lesion, for which the diagnosis and treatment are usually difficult. Though embolization and sclerotherapy are the primary treatment strategies, traditional surgical resection remains a valuable option.

Case Presentation

Herein, we present a 32-year-old female diagnosed with a massive abdominopelvic arteriovenous malformation that originates from the splenic artery and drains into the portal vein. The vascular lesion was evaluated with multiple imaging modalities and then surgically resected successfully. The patient was discharged post-operatively on day 6 and free of symptoms during the 12-month follow-up.

Conclusion

To our knowledge, the presented abdominopelvic arteriovenous malformation is the first to be reported in the literature, with such a rare condition originating from the splenic artery and draining into the portal vein.
Predictors of Lesions Contiguity and Transmurality in Canine Ventricular Models After Catheter Ablation
Authors: El Hajjar Abdel Hadi , Mekhael Mario , Huang Chao , Noujaim Charbel , Zhang Yichi , Kholmovski Eugene , Ayoub Tarek , Lim Chan Ho , Marrouche Nassir
Published: June 2022

Background

Interlesion gaps and transmurality of lesions after catheter ablation can precipitate suboptimal efficacy in preventing arrhythmias.

Aims

We aim to assess predictors of acute transmural lesion formation and the interlesion distance threshold for creating a continuous, chronic scar after ventricular ablation.

Materials and Methods

Ablation procedures were performed on 7 canines followed by late gadolinium enhancement MRI (LGE-MRI). Transmurality of lesions was assessed by 2 independent operators. Ablation parameters such as duration (s), power (W), temperature (C), contact force (CF) (g), were collected for each ablation point. After 7-12 weeks, LGE-MRI was performed, followed by euthanasia, and heart excision. Some lesions were created in pair. Lesion pairs were spaced 7-21 mm apart as measured by Electroanatomic mapping (EAM), with different operating parameters (power 35 or 50W, duration of energy delivery 10, 20 or 30s and contact force of 10g or above). We performed a logistic regression analysis to determine predictors of transmural lesion formation.

Results

Eighty-one radiofrequency ablation were performed in total [33 in the Left ventricle (LV) and 48 in the Right ventricle (RV)]. Higher CF was a significant predictor of transmural lesion formation (β = 0.15, OR = 1.16, 95% CI [1.03 – 1.3], p = 0.01), and lesions delivered in the RV were more frequently transmural than lesions delivered in the LV (β = −2.43, OR = 0.09, 95%CI [0.02 – 0.34], p < 0.001). For the paired analysis, thirty-eight lesions were created contiguously: fourteen connected lesions and twenty-four unconnected lesions. EAM distance was significantly larger in unconnected lesions than connected lesions (16.17 ± 0.92 mm vs. 11.51 ± 0.68 mm, respectively, p < 0.05). We concluded that an interlesion distance of less than 10 mm is required to prevent gap formation. Average volumes in unconnected lesions (n = 24) at the acute and chronic stages were 0.55 ± 0.11 cm3 and 0.20 ± 0.02 cm3, respectively. On average, lesion volumes were 64% (p < 0.05) smaller at the chronic stage compared to the acute stage. Among connected lesions (n = 14), we observed a volume of 1.19 ± 0.8 cm3 and 0.39 ± 0.15 cm3 at the acute and chronic stages, respectively. These connected lesions reduced in volume by 67% on average.

Conclusion

To create contiguous scars on the ventricular endocardial surface, paired lesions should be spaced less than ten millimeters apart. Higher contact force should be used in ventricular ablation to create transmural lesions.
Impact of Iodinated Contrast Media in Patients Received Percutaneous Coronary Intervention: Focus on Thyroid Disease
Authors: Chen Yasha , Zheng Xueyang , Li Na , Niu Wenhao , Hu Bowen , Yuan Xun , Liang Chun , Lin Yunling
Published: June 2022

Background

With the rapid advance in percutaneous coronary intervention (PCI) technology, patients absorb large volume of iodinated contrast media (ICM). Recent studies suggested that ICM may lead to hyperthyroidism, but the association between ICM volume and thyroid is still unclear. We sought to evaluate the long-term influence of ICM on thyroid dysfunction and disease in patients received PCI.

Methods

This single-center retrospective study included consecutive coronary artery disease (CAD) patients. A covariance (ANCOVA) model was performed to evaluate the change of serum TSH, FT3 and FT4 before and one-year after the PCI procedure. Restricted cubic splines and logistic regression were performed to evaluate the association between ICM volume and thyroid disease.

Results

2062 patients met inclusion criteria (1381 patients in the low-volume group and 681 patients in the high-volume group). The high-volume group was 0.238 ± 0.092 pmol/L higher than the low-volume group (P = 0.010) in the serum FT4. Restricted cubic splines show that there were linear dose-response relationships for ICM volume and composite endpoint and hyperthyroidism. In all models, there were significant differences in composite endpoint between the two groups. (OR 1.75, 95% CI (1.05, 2.92), P = 0.032, OR 1.73, 95% CI (1.01-2.96), P= 0.032 and OR 1.83, 95% CI (1.09-3.06), P= 0.022, respectively). The positive results were also showed for hyperthyroidism in all models (OR 2.35, 95% CI (1.14-4.84), P = 0.021, OR 10.36, 95% CI (1.20-89.00), P = 0.033 and OR 2.35, 95% CI (1.13-4.87), P = 0.022, respectively).

Conclusion

The present analysis gives an overview that ICM volume is associated with an increased risk of thyroid dysfunction and thyroid disease.