bluuebunny/crossref_metadata_2025 huggingface dataset:
Skin testing and drug challenge in the evaluation of drug hypersensitivity reactions
Authors: Wolfson Anna R. , Banerji Aleena
Published: January 2021

Immediate hypersensitivity to drugs is characterized by symptoms such as hives, swelling, and wheezing. To prevent a negative impact on care, assessment by an allergist is important. Evaluation requires a clear clinical history, but it is often lacking or vague, which makes a diagnosis difficult. Allergists instead can use skin testing and drug challenge to evaluate drug hypersensitivity reactions, which help the patient and provider understand the causative drug(s) and, more importantly, enables the use of the exonerated drug(s). Although penicillin skin testing is standardized, well described, and widely used, skin testing for most other drugs requires the use of a nonirritating skin testing concentration that can have a low negative predictive value. Drug challenges are the criterion standard for confirming tolerance. The allergist must obtain an in-depth clinical history and then follow with skin testing and/or drug challenges when indicated to determine which drugs can be de-labelled and which should be avoided. In this review, we focused on the evaluation of drug hypersensitivity reactions to antibiotics, perioperative agents, biologics, and chemotherapeutics.
Serum levels of specific immunoglobulin E toDermatophagoides pteronyssinusallergen components in patients with allergic rhinitis or/and asthma
Authors: Zou Xiangwei , Hu Haisheng , Huang Zhifeng , Liao Chenxi , Huang Liuqiao , Luo Wenting , Jiang Mei , Sun Baoqing
Published: January 2021

Background:House-dust mites (HDM) allergen is one of the most important allergens in southern China; however, studies on the Dermatophagoides pteronyssinus components are relatively lacking.Objective:This study analyzed the molecular components of D. pteronyssinus in patients with allergic asthma (AS) and/or allergic rhinitis (AR) sensitized to D. pteronyssinus, and aimed to improve HDM immunotherapy in southern China.Methods:Allergen component-resolved diagnosis detection technology was used to detect the serum levels of specific immunoglobulin E (sIgE) to D. pteronyssinus allergen components (Der p 1, 2, 3, 5, 7, 10, and 23) in patients who were sensitized to D. pteronyssinus and with AR (n = 106), AS (n = 144), or AR combined with AS (n = 134).Results:The highest positive rates ofD. pteronyssinuscomponents were Der p 1 (94.8%), followed by Der p 2 (77.6%), Der p 23 (62.5%), Der p 7 (34.6%), Der p 5 (17.7%), Der p 10 (12.2%), and Der p 3 (2.6%). Patients with AR+AS had the highest positive rates to Der p 2 (85.8%), Der p 23 (62.7%), Der p 7 (40.3%), Der p 5 (25.0%), and Der p 10 (16.4%). Der p 1 had the highest positive rate in patients with AR (95.3%). The Der p 3 positive rate in patients with AS (6.0%) was higher than that in patients with AR (0.0%, χ2= 6.872, p < 0.05) and patients with AR+AS (0.7%, χ2= 6.063, p < 0.05) Among the patients with AR+AS, 19.1% were co-sensitized to Der p 1, Der p 2, Der p 23, and Der p 7. Interestingly, only one patient with AR was exclusively sensitized to Der p 23. An optimal scale analysis showed that Der p 5, Der p 23, and Der p 7 had strong connection (Cronbach α = 93.7%).Conclusion:Der p 1 and Der p 2 were the main sensitization components of D. pteronyssinus, and patients with AS+AR had the highest positive rate for five of seven D. pteronyssinus allergen components. This research can provide suggestions for personalized HDM-specific immunotherapy in southern China.
Morfologia dos órgãos genitais masculinos do punaré (Thrichomys laurentius)
Authors: Figueredo Willian Xavier , Guerra Ricardo Romão , Carvalho Lucas Rannier Ribeiro Antonino , Pereira Helder Camilo da Silva , Oliveira Moacir Franco
Published: January 2021

O punaré é um pequeno roedor de hábitos diurnos e noturnos, habitando principalmente áreas rochosas. Neste estudo objetivou-se estudar macroscopicamente e microscopicamente o aparelho genital masculino do punaré. Os animais foram eutanasiados sendo então realizadas as coleta de testículos e demais estruturas genitais. Os testículos apresentaram túbulos seminíferos com as células da linhagem espermática e de Sertoli. O epidídimo apresentou seus túbulos compostos por um epitélio pseudoestratificado com estereocílios, composto por células basais e prismáticas. O ducto deferente apresentou mucosa pregueada formada por um tecido epitelial prismático simples, onde observou-se duas camadas de músculo liso, uma interna circular e uma externa longitudinal, podendo-se observar ainda uma adventícia composta de tecido conjuntivo denso não-modelado. A próstata possuiu um parênquima que pode ser dividido em duas regiões; uma com alvéolos glandulares apoiados em grande quantidade de musculo liso, e outra com alvéolos glandulares circundados com menor quantidade de músculo liso, sendo apoiado em um tecido conjuntivo denso não-modelado. A glândula vesicular possuiu uma mucosa composta por um epitélio cúbico simples sendo formada por túbulos que podem ser retos ou tortuosos com secreção presente no interior do lúmen tubular. Concluímos que os órgãos genitais masculinos do punaré são semelhantes macroscopicamente aos órgãos dos roedores de forma geral, havendo microscopicamente algumas diferenças entre outras espécies de roedores.
Produção de cultivares de feijão submetidas a adubação foliar molíbdica
Authors: Silva Ricardo Barros , Barbosa Wemerson Saulo da Silva , Albuquerque Neto João Cardoso de , Santos Wellington Manoel dos , Santos Neto Antônio Lucrécio dos , Souza Ademária Aparecida de
Published: January 2021

Pesquisas voltadas a seleção de cultivares de feijão e adubação foliar molíbdica no estado de Alagoas ainda são escassas. Neste experimento avaliou-se o desempenho de cultivares de feijão comum sob ausência e presença de adubação foliar molíbdica no Agreste alagoano. O experimento foi conduzido entre maio e julho de 2016 no município de Arapiraca – AL. O delineamento utilizado foi em blocos casualizados, com quatro repetições, em um arranjo 5 x 2, referente as cultivares de feijão (BRS Ametista, BRS Cometa, BRS Estilo, BRS Notável e BRS Pérola) e presença e ausência da adubação foliar molíbdica. O potencial produtivo das cultivares e a interferência da adubação foliar rica em molibdênio foi verificada através de análise estatística das variáveis: produtividade (kg ha-1), número de sementes por planta, número de vagens, número de sementes por vagem e peso de sementes por planta (g). A adubação foliar molíbdica e a interação cultivares x adubação foliar molíbdica foram não significativas. As cultivares não apresentaram diferença para o número de sementes e vagens por planta. A cultivar BRS Ametista apresentou o maior peso de sementes por planta (18,17 g), por conseguinte a maior produtividade (3.750 kg ha-1), seguida da cultivar BRS Estilo (3.126 kg ha-1), ambos materiais mostraram-se como candidatos promissores sob as condições edafoclimáticas trabalhadas. As Cultivares BRS Ametista e Estilo são as mais produtivas no Agreste alagoano. O molibdênio via foliar aos 35 e 45 dias após a semeadura não é viável.
VOGUE WORD: INNOVATION OR REACTUALIZATION?
Authors:   KSPU named after V.P. Astafiev, Vasiliev A.D.
Published: January 2021

Statement of the problem. The practice of using a living language naturally and constantly gives rise to various innovations. At the vocabulary and phraseological level, this is primarily the emergence of new units. These include primarily foreign-language borrowings, designed, as a rule, to denote some previously unknown realities – however, today other factors are most effective. The introduction of lexical archaisms, which have long gone into passive reserve, is also quite productive. Both of these methods are actively used in the discourse of the media, which is quite natural: they need to refresh the range of language tools in order to increase the effectiveness of verbal acts that should affect the audience. However, such lexical innovations often become, without much need, extremely frequent in media texts, gaining the status of a fashion accessory. The purpose of the article is a semantic and stylistic analysis of the phenomenon of lexeme reactualization.
Spirituality concept in Russian language worldview: profane and religious components (according to materials of explanatory dictionaries of contemporary Russian language)
Authors:   Siberian Federal University (Krasnoyarsk), Yemelyanova O.N.
Published: January 2021

Statement of the problem. The article examines the content of the spirituality concept, formed by the explanatory dictionaries of the modern Russian literary language; the change in its (concept) functional-stylistic lexicographic qualifications as a reflection of the change in value orientations in society. The purpose of the article is to study the lexicographic history of the spirituality concept in a comparative analysis of different dictionaries. The research methodology is based on the comparative method, contextual and, above all, lexicographic analysis of the main explanatory dictionaries of the Russian language. Research results. The study showed that there is no strict unification in the interpretation and functional-stylistic qualifications of the concept under study in the explanatory dictionaries of the Russian language. Conclusions. In modern domestic explanatory lexicography, there is no unified approach both to understanding the content (interpretation) of the spirituality concept, and in its functional and stylistic qualifications. The author’s contribution consists in a large-format (all the main explanatory dictionaries of the modern Russian language) and a very detailed study, which has not been carried out earlier in relation to this very concept.
CHARACTERISTIC OF INSTAGRAM ACCORDING TO THE ASSOCIATIVE EXPERIMENT: EXPERIENCE OF INTERPRETATION
Authors:   KSPU named after V.P. Astafiev, Asrori Sh. , Osetrova E.V. ,   KSPU named after V.P. Astafiev
Published: January 2021

Social networks are developing the function of mass informing the population, becoming a kind of “people’s” media, taking a leading role in informing Internet users. This defines the statement of the problem within the boundaries of the analysis undertaken, the purpose of which is to find out the content of the attitude towards Instagram – one of the most popular social networks. The scientific basis of the research is formed by works devoted to professional and ethical standards in modern media and social networks, as well as linguistic works developing the methodology of the associative experiment. The research material was the results of a chain associative experiment (September 2020, Krasnoyarsk; respondents were Instagram users, aged 20 to 45). As a result, the characteristics of the Instagram social network were obtained and interpreted according to the data of the linguistic associative experiment. The received reactions record the attitude of Internet users to this social network as to mass media. These reactions characterize Instagram in three aspects: parameters of its connection with the mass audience (accessibility, trust, unreliability); formally linguistic qualities of content (slang, jargon, illiteracy); its content concerning the main aspects of human being – physical, mental and social. The final conclusions are determined as follows. The specificity of the subjective attitude towards this social network is a large number of evaluative reactions that are opposite in sign. Cruelty / aggression as qualifying characteristics of Instagram content, together with its formal language features – illiteracy, profanity, slang and jargon – are clearly negative. At the same time, in the group consciousness, Instagram is a mass media that provides a wide variety of meaningful information, causing the natural interest of users. This is related to the fact that the negative characteristics are compensated by a large number of positive reactions: more than 50 % of them have a positive assessment (from accessibility to beauty and culture).
SIBERIA AS AN ANTI-UTOPIA IN A.V. RUBANOV’S DILOGY “CHLOROPHYLIA” AND “LIVING EARTH”
Authors:   Altai State Pedagogical University (Barnaul), Bogumil T.A.
Published: January 2021

Statement of the problem. The main focus of the article is on the problem of interaction between space (Siberia) and culture (utopian tradition) that constitutes the range of interests for researchers of a Siberian text, in a broader sense, of any local text, as well as for representatives of geocultural and geopoetic approaches. The objectives of this study are to identify works in which (anti) utopia is geographically localized in Siberia, with the exception of the already sufficiently studied topic of Belovodye; to characterize the functions of the Siberian locus in the artistic world of A.V. Rubanov’s dilogy “Chlorophylia” and “Living Earth”. Research results. As a result, a line of succession of the utopian tradition was outlined: from F.V. Bulgarin through A.K. Gastev to the novels of A.V. Rubanov. Conclusions. It was revealed that in A. Rubanov’s dilogy the space of Siberia consistently changes its functions: it exists in opposition to Moscow, to the center and the synecdoche of Russia; it is a colony and a condition for the existence of the Moscow utopia; it is a place of exile and post-apocalyptic “savagery” as the basis of a potential revival; it is a proper utopian city, an alternative capital.
DIRECT ACTIONS AGAINST INSURERS IN CROSS-BORDER TRAFFIC ACCIDENTS IN AN EUROPEANISED PRIVATE INTERNATIONAL LAW – WHAT PROTECTION FOR THE INJURED PARTIES?
Authors: Vyshka Klea
Published: January 2021

This article offers a discussion of the law applicable to cross-border traffic accidents, from the perspective of the protection of injured parties. The introduction of principles like direct actions against insurers by injured third parties (forum actoris), mostly because of CJEU’s liberal approach, puts into question the relationship between European private international law and national Member State rules of conflict-of-laws. This article aims to propose an answer to the question “Does the European private international law set of rules offer an adequate protection for the injured parties?” with the view of offering also a few recommendations for the reformation of the Rome II Regulation.
ODGOVOR DRŽAVE NA BOLEST COVID-19 - NA PRIMJERIMA HRVATSKE I SRBIJE
Authors: Nastić Maja
Published: January 2021

Given the current pandemic coronavirus, the paper analyzes the state’s response to the dis- ease caused by the virus (COVID-19) from the standpoint of two neighbouring countries i.e. the Republic of Croatia and the Republic of Serbia. Special attention was paid to the states’ response to the pandemic from human rights perspective. The research was conducted into the patterns of their “struggle”, especially as regards the human rights restrictions they had opted for within their constitutional framework. The starting point of the paper was that human rights often are the victims of the crises and that they are easily restricted for a longer periods. In this respect, the author deals with possible answers to the questions about the quality and content of human rights, and how the protection of human rights was ensured in these exceptional circumstances. This legal framework was linked to current statistics on the number of COVID-19 cases. Having analyzed the response of the two states, it could be noted that both states have constitutional provisions governing the state of emergency, allowing them the rule of law in these exceptional circumstances. Both constitutions recognize a list of human rights that may be derogated in state of emergency. However, in Croatia, the state of emergency was not introduced, and the human rights were restricted in accordance with the given epidemiological situation. In Serbia, the struggle against COVID-19 took place in state of emergency and was marked by an extremely restrictive regime of human rights, which was partly in conflict with the constitutional order. The constitutional concept of absolute protection of human rights, in their broadest sense, had proved unsustainable in practice.
ISKUSTVO DOBNE DISKRIMINACIJE U OSTVARIVANJU PRAVA NA JEDNAKE UVJETE RADA TE PRAVA NA JEDNAKE MOGUĆNOSTI NAPREDOVANJA U RADNOM ODNOSU U SUSTAVU ZNANOSTI I VISOKOG OBRAZOVANJA REPUBLIKE HRVATSKE
Authors: Bjelić Gaćeša Dragana
Published: January 2021

Age discrimination has become an exceptional problem in rapidly aging societies such as Croatia. The paper aims at analysing the age discrimination issues in scientific and higher education system of the Republic of Croatia, specifically at verifying the presence of discrimination based on age and according to experience of the respondents included in the survey concerning equal conditions of work and equal advancement opportunities. For the purpose of analysis, an empirical research has been conducted by studying employees at two Croatian universities i.e. Josip Juraj Strossmayer University of Osijek and the University of Rijeka. Data were gathered by the means of an online questionnaire hosted on the Google Drive plat- form in the period from 29 May to 21 June 2017. A contact list of respondents’ e-mail ad- dresses was compiled using information obtained from official web sites of the Universities’ constituencies as well as their Rectors’ offices. There were 2958 addresses in total, out of which 1506 were at the University of Rijeka and 1452 addresses at Josip Juraj Strossmayer University of Osijek. The empirical research results indicated the following: 1) Age discrimination regarding equal working conditions is present in the experience of the respondents – the employees in scientific and higher education system of the Republic of Croatia, 2) Age discrimination regarding equal advancement opportunities is present in the experience of the respondents – the employees in the scientific and higher education system of the Republic of Croatia 3) As regards the equal working conditions, there are only differences among the respondents in view of their gender 4) As regards the equal advancement opportunities, there are differences among the respondents considering respondents’ levels of education and type of their positions (teaching, administrative and technical, auxiliary personnel).
Creative Thinking Learning of Physical Education: Can Be Enhanced Using Discovery Learning Model?
Authors: Dupri  , Nazirun Novia , Candra Oki
Published: January 2021

The teacher-centered mindset and teaching methods are still teacher-centered, closing the space for students to develop their creative thinking abilities. This study aims to determine the thinking skills of students in physical education learning using discovery learning models. This study used a quasi-experiment method and a pretest and posttest control group design. The research sample was obtained by means of cluster random sampling with a sample amount of 70 people. The instrument that used to measure students' creative thinking skills used the Torrance Test of Creative Thinking (TTCT) which before be tested, it have conducted the validity and reability. The t test was used as the analysis of this study. Discovery learning model is proven to be able to develop students' creative thinking skills when learning physical education. This is proven by the sig value. 0,000. So the discovery learning model in physical education learning will be able to develop creative thinking on students. This learning model must be applied in various fields of education. Research on the same topic should be carried out in the future, with the variability of different educational levels of subjects or educational institutional settings
Die Gestaltung des Erfolgsmodell Fahrradstraße
Authors: Becker Thilo
Published: January 2021

In Fahrradstraßen können Radfahrende nebeneinander fahren, andere Fahrzeuge sind nur ausnahmsweise zugelassen und es gilt eine Höchstgeschwindigkeit von 30 km/h. Zahlreiche Städte haben in den letzten Jahren Fahrradstraßen eingerichtet und planen einen weiteren Ausbau. Dieses Wachstum findet trotz vieler Unzulänglichkeiten wie einer schwierigen Priorisierung an Knotenpunkten, mangelhafter Regelkenntnis unter den Verkehrsteilnehmenden und einer regelmäßigen Freigabe für Kfz-Verkehre statt. Verkehrsplanerisch ist das Wachstum sehr erfreulich zu bewerten, da sich Fahrradstraßen als relativ sicher erwiesen haben und positiv wahrgenommen werden. Statt in kleinen Schritten neue Fahrradstraßen auszuweisen, sollten ihre Alleinstellungsmerkmale, insbesondere das Recht auf Nebeneinanderfahren, auf alle Tempo-30-Zonen übertragen werden. Innerhalb dieses etablierten Netzes mit 70 bis 80 % aller Straßen könnten Fahrradrouten mit verkehrsplanerischen Mitteln weiter priorisiert werden und es könnte mit geringem Aufwand ein großer Schritt für die Radverkehrsförderung erreicht werden.
Highly Optically Responsive Divalent Benzimidazolium-Based Axles with Pseudorotaxane Potential
Authors: Taimoory S. Maryamdokht , Yu Xiao , Trant John F.
Published: January 2021

Mono and (bis)benzimidazoliums were evaluated both experimentally and computationally for their potential as building blocks of pseudopolyrotaxane axles. Their aggregation and optical behavior, along with their potential to form a [2]pseudorotaxane with dibenzyl-24-crown-8, was studied through the synergistic application of 1D/2D and diffusion ordered NMR spectroscopy, ultraviolet-visible & fluorescence spectroscopy, and time-dependent density functional theory. Their unique optical behaviour was measured and modeled as a function of protonation state, solvent, and concentration. The axles show strong solvochromaticism and a very pronounced concentration-dependent optical profile. This axle with multiple recognition sites, has the potential to form pseudorotaxanes with tunable optical behavior.
Retinal Organoids On-a-Chip: A 3D Printed Micro-Millifluidic Bioreactor for Long-Term Retinal Organoid Maintenance
Authors: Xue Yuntian , J. Seiler Magdalene , Tang William C. , Wang Jasmine Y. , Browne Andrew
Published: January 2021

Retinal degeneration is a leading cause of vision impairment and blindness worldwide and medical care for advanced disease does not exist. Stem cell-derived retinal organoids (RtOgs) became an emerging tool for tissue replacement therapy. However, existing RtOg production methods are highly heterogeneous. Controlled and predictable methodology and tools are needed to standardize RtOg production and maintenance. In this study, we designed a shear stress-free micro-millifluidic bioreactor. We used a stereolithography (SLA) 3D printer to fabricate a mold from which Polydimethylsiloxane (PDMS) was cast. The multi-chamber bioreactor design and fabrications methods easily combined micro and millimeter features with very low cost and short manufacturing time. We optimized the chip design using in silico simulations and in vitro evaluation to optimize mass transfer efficiency and concentration uniformity in each culture chamber. We successfully cultured RtOgs on an optimized bioreactor chip for 37 days. We also characterized the RtOgs produced by static dish culture and chip culture methods using qualitative and quantitative techniques. Phase contrast imaging showed that both conventional and chip-cultured RtOgs developed a transparent outermost surface structure. Fluorescence lifetime imaging (FLIM) showed that RtOgs on the chip had significantly lower long lifetime species (LLS) ratio than static cultured ones, which demonstrated that bioreactor cultured RtOgs exhibited less oxidative stress. RtOgs in bioreactor culture demonstrated higher NADH signal overall, but both bioreactor and conventional cultures showed similar free/bound NADH ratio over time, which indicated normal differentiation time course. RtOg gene expression was examined by fluorescence imaging and quantitative polymerase chain reaction (qPCR) analyses. RtOgs in both groups showed thick nuclear outer layers expressing CRX on day 120 of differentiation. The gene profiling showed both groups expressed retinal progenitor genes and most of the tested photoreceptor markers. We, therefore, validated an autonomous micro-millifluidic device with significantly reduced shear stress and lower oxidative stress to produce RtOgs of equal or greater quality than those maintained in conventional static culture.
Providing Adverse Outcome Pathways from the AOP-Wiki in Semantic Web Format to Increase Usability and Accessibility of the Content
Authors: Martens Marvin , Evelo Chris , Willighagen Egon
Published: January 2021

The AOP-Wiki is the main environment for the development and storage of Adverse Outcome Pathways. These Adverse Outcome Pathways describe mechanistic information about toxicodynamic processes and can be used to develop effective risk assessment strategies. However, it is challenging to automatically and systematically parse, filter, and use its contents. We explored solutions to better structure the AOP-Wiki content and to link it with chemical and biological resources. Together this allows more detailed exploration which can be automated.

We converted the complete AOP-Wiki content into Resource Description Framework. We used over twenty ontologies for the semantic annotation of property-object relations, including the ChemInformatics Ontology, Dublin Core, and the Adverse Outcome Pathway Ontology. The latter was used over 8,000 times. Furthermore, over 3,500 link-outs were added to twelve chemical databases and over 6,500 link-outs to four gene and protein databases.

SPARQL queries can be used against the Resource Description Framework to answer biological and toxicological questions, such as listing measurement methods for all Key Events leading to an Adverse Outcome of interest. The full power that the use of this new resource provides becomes apparent when combining the content with external databases using federated queries. For example, we can link genes related to Key Events with molecular pathway on WikiPathways in which they occur and find all Adverse Outcome Pathways caused by stressors that are part of a particular chemical group. Overall, the AOP-Wiki Resource Description Framework allows new ways to explore the rapidly growing Adverse Outcome Pathway knowledge and makes the integration of this database in automated workflows possible.
Effectiveness of Tech Neck Exercise among adult smartphone user with Text Neck Syndrome
Authors: Resmy V  , Priyanka R
Published: January 2021

A mobile phone is a gadget which is utilized for voice and information correspondence. Alongside the fundamental voice limit of a phone, current mobiles may support various additional features, for instance, text advising, email, gaming, camera, Whatsapp, Facebook, GPS and so on. The neck or cervical spine is a system which involves nerves, bones, joints, and muscles which are coordinated by the brain and the spinal cord. Besides, exacerbation along the nerve pathways can cause torment into the shoulder, arm and hand. "Text neck" is the term used to depict the neck torment and harm bolstered from looking down at the cell phone, tablets or distinctive far off gadgets too constantly and for actually quite a while. So the current examination points are to survey the effectiveness of tech neck exercise among adult smartphone user with text neck syndrome. Quantitative experimental research was conducted among 60 adults. A convenient sampling technique was used to select the samples. Self-structured questionnaires were used to collect the demographic data and pain scale was assessed. The result of the study shows that among 60 samples, it was concluded that "TECH NECK" exercise has no side effects and it is an easy and comfortable method which can be practised for a long time to adult within text neck syndrome.
Analysis of Diabetic Retinopathy Utilizing Exudates Extraction from Image of Fundus Retinal
Authors: Smitha M  , Gunasagar Das  , Parthasarathy MP  , Saravanan V
Published: January 2021

Around 35 level of populace was influenced through Diabetic expert. Thus, it could be prominent vision-compromising infections. It is maximal level of sugar in blood of human causing DR. Moreover, the fundamental driver aimed at visual impairment is approximately 30-65 years individually. Since after DR impact, it hurt veins of retina. Intricate exudates have been the side effects the DR. Picture procedure strategies have been fundamental for defining exudates. Picture handling could be utilized by computation for maintaining a strategic distance from troubles, for example, commotion and sign change during picture measure. It is utilized with broad variety of difference upgrade, edge location and measure of force with various sort of numerical activity applied to enter pictures. Gigantic measure of data can be mined from the picture utilizing picture handling. It very well may be implemented on clinical & farming domain. In this article, handling of Image has been implemented on clinical domain for examining eye illness. Information extraction methods consider tremendous amount data over data set. Putting away and recovering of information is finished by information mining. It is additionally the best strategy for the order. It gives elite precision. In this manuscript, digging Data procedures have been utilized aimed at arrangement beneath factorization. It could be performed relied on seriousness DR level.
一种新联合指标对新生儿体重增重趋势的诊断价值
Authors: 姚 涛 , 白 景鹤 , 邢 军 , 陈 静思
Published: January 2021

目的：通过筛选多个孕检指标建立一种新联合指标，并分析包括新联合指标在内的多个指标对新生儿体重增重趋势的诊断价值。方法：选取2018年1月-12月入院的86名孕妇按照其分娩的新生儿出生体重水平，分为新生儿出生体重大于平均体重组（n=43）、及新生儿出生体重小于或等于平均体重水平组(n=43)。比较两组在孕期增重、孕前BMI、宫高、腹围等十六个指标差异；利用ROC曲线下面积分析每个指标的诊断价值并与联合诊断指标的诊断能力比较。结果：①宫高、孕周、孕期增重、腹围在两组间比较差异有统计学意义（P＜0.05）。②受试者工作曲线显示较高诊断意义的指标分别是孕期增重AUC=0.712、灵敏度65.1%、特异度76.7%；孕周的AUC=0.69、灵敏度76.7%、特异度58.1%；宫高的AUC=0.741，灵敏度90.7%、特异度46.5%；腹围的AUC=0.725、灵敏度62.7%、特异度72.1%。③联合指标的AUC=0.8大于单独各指标的诊断能力（P＜0.05），其灵敏度67.4%、特异度86.5%。结论：宫高灵敏度高于任何指标，而联合指标相比于单独指标预测新生儿体重变化趋势有更高的诊断价值和特异度。因此结合两个指标可以预测新生体重增重趋势。
睡眠-觉醒中神经递质的作用
Authors: 王 敏燕 , 解 雅英
Published: January 2021

睡眠-觉醒的发生和维持在结构上需要多个脑区和多种神经递质系统的支持。目前认为睡眠依赖于腹侧和中间视前区的γ-氨基丁酸（γ-aminobutyric acid,GABA）能神经元, 觉醒依赖于脑干网状结构的谷氨酸（glutamic acid,Glu）能系统、基底前脑和脑干的胆碱能系统、脑干的去甲肾上腺素能系统、5-羟色胺能系统和多巴胺能系统以及下丘脑的组胺能系统和食欲素系统。这些系统在脑内形成了广泛复杂的网络, 但它们在睡眠-觉醒中的作用是不同的。各系统中的神经递质通过各自特殊的信号通路，参与产生觉醒与睡眠的大脑回路，使其相互抑制，从而引起睡眠与觉醒两种状态的转换。
疫苗生产和临床研究的生物安全控制策略初探
Authors: 张 景芝 , 苗 丽 , 李 玥 , 董 玉婷 , 高 红玉 , 姚 佳
Published: January 2021

虽然中国在生物安全领域加入了不少国际公约，但是直到今年才出台《中华人民共和国生物安全法》，同时也在2020年版药典三部中提出了较其他国家药典更严格的《生物制品病毒安全性控制》。生物安全立法的目的就是通过严格防控，保障公共卫生安全和人民生命健康。以此为契机，与同行交流和学习，共同推动中国生物安全和安保事业的进步。
胸部肿瘤调强放射治疗摆位误差的多种因素分析进展
Authors: 任 碧辉
Published: January 2021

经过多年实践发现，胸部肿瘤调强放疗（IMRT）实施过程中会存在不同程度的误差，包括系统误差与随机误差。其中系统误差可以通过对机器的质检和质控予以校准。而随机误差主要与患者摆位的各种因素相关，如体位固定方式、呼吸动度、身体质量指数（BIM）、体表标记线及双上肢的位置等因素，其造成的摆位误差结果在治疗计划中直接影响了计划靶区（PTV）外放边界的大小。临床可通过采取积极可行的方法来提高摆位误差精度。因此，论文对胸部肿瘤患者IMRT时摆位误差的多因素分析作一综述
Medical Compliance Determinants for Tuberculosis Patients in Palembang
Authors: Diesty Uca Ayu Frama , Tjekyan RM. Suryadi , Zulkarnain M.Zulkarnain
Published: January 2021

The majority of countries in the world have tuberculosis, including Indonesia, which has the third rank in the world. This is due to a large number of sufferers who were not successfully cured. One of the factors that influence the recovery of tuberculosis patients is adherence to taking anti-tuberculosis drugs for a certain period of time. Non-adherence to treatment can exacerbate the risk of disease because it can lead to MDR (Multi Drugs Resistant) tuberculosis. This study aims to analyze the determinants of tuberculosis treatment compliance in the city of Palembang. This study used an analytical study with a semi-quantitative approach, with a cross-sectional design. Sampling was carried out by proportional random sampling at 39 Puskesmas Kota Palembang, a total of 243 samples that met the inclusion and exclusion criteria. Data collection was carried out by means of interviews using a questionnaire. Data were analyzed using the chi-square test and multiple logistic regression. Obtained adherence to treatment of tuberculosis patients by 42.8%. There was a significant relationship between perceived benefits (p = 0.000; OR = 3.556), family support (p = 0.000; OR = 3.512), support from health workers (p = 0.001; OR = 2.712), knowledge (p = 0.018; OR = 2,027) with adherence to treatment of tuberculosis patients. The level of compliance with tuberculosis patients in Palembang City is still low, namely 42.8%. The most important determinant of adherence is perceived benefit with a 3.556 times greater opportunity after controlling for other variables.
Perancangan Media Pembelajaran TIK Menggunakan Aplikasi Autoplay Media Studio 8 di SMA Muhammadiyah Padang Panjang
Authors: Afrianti Silvia , Musril Hari Antoni
Published: January 2021

Dalam proses pembelajaran masih menggunakan metode ceramah dan media yang digunakan dalam proses pembelajaran masih menggunakan buku cetak pelajaran TIK. Penelitian ini menggunakan metode research and Development (R&D) versi 4D, yaitu Define, Design, Develop, dan Disseminate. Model pengembangan multimedia yang digunakan dalam penelitian ini yaitu model pengembangan multimedia versi Luther Sutopo yang terdiri dari 6 tahap yaitu concept, design, material collecting, assembly, testing dan distribution. Uji produk yang digunakan pada penelitian ini adalah uji validitas oleh pakar yaitu ahli media, ahli pendidikan, ahli teknologi informasi, uji pratikalitas oleh guru pelajaran TIK dan uji efektifitas oleh siswa. Hasil penelitian penulis berupa media video tutorial menggunakan aplikasi autoplay media studio yang bisa digunakan oleh guru dan siswa pada mata pelajaran TIK. Penelitian ini menggunakan metode research and Development (R&D) versi 4D, yaitu Define, Design, Develop, dan Disseminate. Model pengembangan multimedia yang digunakan dalam penelitian ini yaitu model pengembangan multimedia versi Luther Sutopo yang terdiri dari 6 tahap yaitu concept, design, material collecting, assembly, testing dan distribution. Uji produk yang digunakan pada penelitian ini adalah uji validitas oleh pakar yaitu ahli media, ahli pendidikan, ahli teknologi informasi, uji pratikalitas oleh guru pelajaran TIK dan uji efektifitas oleh siswa. Hasil penelitian penulis berupa media video tutorial menggunakan aplikasi autoplay media studio yang bisa digunakan oleh guru dan siswa pada mata pelajaran TIK.
MODEL FOR APPLICATION OF STEM APPROACH IN CONDITIONS OF DISTANCE LEARNING – STEM HOME LABORATORY
Authors:   „A. G. Kodzhakafaliyata” school, Burgas, Stoyanova Greta
Published: January 2021

The sudden shift to distance learning caused by the COVID-19 virus emergency has posed a serious challenge to schools. This article presents a successful model for applying the STEM approach in science education at the Alexander Georgiev-Kodzhakafaliyata Primary School in Burgas. In the conditions of synchronous distance learning in MS Teams environment, students conduct experiments with handy tools and materials at home, during online classes or as homework assignments, then describe the experiments in presentations and share them with their classmates during the project week ( April holidays and at the end of the year). The application of STEM home laboratory combines knowledge from different disciplines, diversifies and facilitates learning, enables learning by doing things, which most stimulates the curiosity of students. Thus, they casually acquire skills for planning and conducting a scientific experiment, generating hypotheses and reasoning, measuring results and formulating conclusions. At the same time, soft skills for teamwork, creative and critical thinking, presentation skills are formed and upgraded.
Precisión Bioestratigráfica y Paleoambiental del miembro Temascalapa (formación Huayacocotla) con base en Gleviceras Buckman, 1918 (Ammonoidea, Oxinoticeratidae Hyatt, 1875), en la región Otomí-Tepehua, México Centro-Oriental
Authors: Esquivel Carlos , León Olvera Rita Gabriela
Published: January 2021

Se reporta por primera vez el hallazgo paleontológico de un amonite Oxinoticerátido en la localidad de Temascalapa, región Otomí-Tepehua del estado de Hidalgo, México centro-oriental. Se determina taxonómicamente el fósil como Gleviceras Hyatt 1875 en estratos de la facies homónima Temascalapa, antes conocida informalmente como formación Temascalapa. La determinación permite ubicar el fósil durante el Sinemuriano Superior en zona raricostatum, lo que la homologa con las unidades Despí y Tenango de la Formación Huayacocotla. Además el análisis de morfología funcional del fósil, apoyado en la petrología de la unidad previamente publicada permite asegurar que la unidad Temascalapa pertenece a la Formación Huayacocotla y se descarta definitivamente el criterio de múltiples formaciones de autores previos. La unificación con la Fm Huayacocotla permite aplicar a esta unidad la determinación del ambiente sedimentario en cuenca intraarco en fondos disóxicos ya conocida.
Recursos tecnológicos aplicados al desarrollo del tiempo verbal pasado en inglés
Authors: Quintero Espinoza Ruben Octavio , Fong-Flores Jesús E. , Fierro-López Laura E. , Galván-De la Fuente Tatiana E.
Published: January 2021

La conciencia lingüística desde la comprensión del tiempo verbal pasado, representa un punto de complejidad para el estudiante. Se entiende que, en el proceso y acceso al inglés como lengua meta existen representaciones del error que son elementos de orden transitorio. Nuestra investigación propone recursos tecnológicos aplicados a la comprensión y desarrollo del tiempo verbal pasado, que se sustenta a partir del análisis, clasificación y descripción de errores escritos por estudiantes del tronco común de la Facultad de Idiomas, Mexicali de la Universidad Autónoma de Baja California. Además, la propuesta se fundamenta a partir de la encuesta de opinión que muestra la percepción del estudiante hacia el uso y preferencia de los recursos tecnológicos. Siendo una investigación de enfoque mixto, de alcance descriptivo y de diseño no experimental.
Covid-19: Implementation e-voting Blockchain Concept
Authors: Kamil Mustofa , Bist Ankur Singh , Rahardja Untung , Santoso Nuke Puji Lestari , Iqbal Muhammad
Published: January 2021

The current situation of the Covid-19 pandemic is currently increasing public concern about the community. The government has especially recommended Stay at Home and the implementation of PSBB in various regions. One of the concerns is when the election of regional leaders to the general chairman. Even though there is already a safeguard regulation, this is not considered safe in the current Covid-19 pandemic. The solution in this research is the use of a blockchain-based E-voting system to help tackle election unrest during Covid-19. Where e-voting with blockchain technology can be carried out anywhere through the device without the need to be present in the voting booth, reducing data fraud, accurate and decentralized voting results that can be accessed by the public in real-time. The use of cryptographic protocols is applied for data transfer between system components as well as valid system security. This research method uses SUS trial analysis in a significant system of the Covid-19 pandemic situation. The implication that the SUS Score analysis shows 90 shows an acceptable E-voting system, meaning that the community can accept it because it brings positive and significant impacts such as effectiveness and efficiency.
Fuzzy C-Means Clustering Algorithm For Grouping Health Care Centers On Diarrhea Disease
Authors: Chusyairi Ahmad , Saputra Pelsri Ramadar Noor
Published: January 2021

In Indonesia, public health services at the city or district level are carried out by regional public hospitals or “puskesmas” (health care centers), especially in Banyuwangi regency, East Java, Indonesia that has 45 health care centers spread throughout the villages. This research focused on the deaths of babies caused by diarrhea diseases, which are the second leading cause of death among children younger than 5 years globally. All of the health care centers need to be divided into 3 groups to find out which health care centers have the least, most moderate, and many diarrhea sufferers. Fuzzy C-Means algorithm is used to overcome this problem. The result from this research shown that 2 health care centers have the smallest member of diarrhea sufferers, 14 health care centers have a medium member of diarrhea sufferers, and the rest have a large number of diarrhea sufferers. From the result of this study, it can be a reference for the health department center in dealing with diarrheal diseases, accordingly, the infant mortality rate due to diarrheal diseases can be lowered to health care centers that have high diarrhea sufferers.
Predicting the Spread of the Corona Virus (COVID-19) in Indonesia: Approach Visual Data Analysis and Prophet Forecasting
Authors: Husein Amir Mahmud , Hutabarat Jefri Poltak , Sitorus Jeckson Edition , Giawa Tonazisokhi , Harahap Mawaddah
Published: January 2021

The development trend of the coronavirus pandemic (COVID-19) in various countries has become a global threat, including in Southeast Asia, such as Indonesia, the Philippines, Brunei, Malaysia, and Singapore. In this paper, we propose an Exploratory Data Analysis (EDA) model approach and a time series forecasting model using the Prophet method to predict the number of confirmed cases and cases of death in Indonesia in the next thirty days. We apply the EDA model to visualize and provide an understanding of this pandemic outbreak in various countries, especially in Indonesia. We present the trends in the spread of epidemics from the countries of China from which the virus originates, then mark the top ten countries and their development and also present the trends in Asian countries. We present an analytical framework comparing the predicted results with the actual data evaluated using the MAPE and MAE models, where the prophet algorithm produces good performance based on the evaluation results, the relative error rate of our estimate (MAPE) is around 6.52%, and the model average false 52.7% (MAE) for confirmed cases, while case mortality was 1.3% for the MAPE and MAE models around 236.6%. The results of the analysis can be used as a reference for the Indonesian government in making decisions to prevent its spread in order to avoid an increase in the number of deaths
PENENTUAN DEBIT ANDALAN DENGAN METODA F J MOCK DI DAERAH ALIRAN SUNGAI CILIWUNG
Authors: Sudinda Teddy W
Published: January 2021

Perubahan tata guna  lahan di DAS Ciliwung mengakibatkan berkurangnya daerah resapan air. Daerah resapan memiliki fungsi untuk menangkap, menyimpan dan mengalirkan air melalui badan sungai menuju laut. Sehingga dengan menurunnya fungsi daerah resapan akibat dari perubahan penggunaan lahan menjadi daerah kedap menyebabkan pengaruh terhadap siklus hidrologi. Hal ini berkaitan dengan keseimbangan air daerah tersebut yaitu dengan menurunnya laju infiltrasi ke dalam tanah akibat meningkatnya daerah pemukiman atau lahan terbangun yang menyebabkan peningkatan laju aliran permukaan dan pengurangan penyimpanan air tanah. Perubahan penggunaan lahan  mengakibatkan debit aliran sungai menjadi melimpah pada musim hujan dan mengalami kekeringan pada musim kemarau. Oleh karena itu untuk mengetahui debit aliran sungai   pada suatu waktu dan daerah tertentu dibutuhkan  analisa debit andalan dengan menggunakan  Model FJ. Mock. Kata Kunci :   Aliran Dasar, Infitrasi, Aliran permukaan
PERENCANAAN INSTALASI PENGOLAHAN AIR LIMBAH DOMESTIK DI INDUSTRI PENGOLAHAN MAKANAN
Authors: Arifudin Arifudin , Setiyono Setiyono , Priyanto Fajar Eko
Published: January 2021

Industri pengolahan makanan dalam melakukan kegiatannya membutuhkan air bersih untuk memenuhi keperluan domestiknya. Sebanyak 80% dari pemakaian air bersih tersebut akan dibuang sebagai air limbah. Air limbah ini bila tidak dikelola dengan baik dapat mencemari lingkungan. Oleh karena itu air limbah tersebut harus diolah terlebih dahulu sebelum dibuang ke saluran umum. Teknologi biofilter dapat diaplikasikan untuk mengolah air limbah domestik sehingga menghasilkan air olahan yang layak dibuang ke saluran umum. Tujuan dari kegiatan ini adalah merencanakan Instalasi Pengolahan Air Limbah (IPAL) domestik di Industri Pengolahan Makanan dengan menggunakan teknologi biofilter.Kata Kunci: Limbah domestik, industri pengalahan makanan, biofilter
Assessment of cardiovascular and renal functions during treatment with Desmodium adscendens therapy
Authors: Seriki Samuel Adinoyi
Published: January 2021

Desmodium adscendens is a rain forest medicinal herb used in managing quite a number of medical conditions. Its efficacy in the treatment of several diseases has made it a first line herb for doctors, especially in managing all forms of spasm. It is however common knowledge that some of these medicinal herbs impact severely on the normal functioning of some vital organs of the body during their administration. The present study was carried out to assess the renal and cardiovascular performance in subjects undergoing treatment with Desmodium adscendens with a view to advising against its indiscriminate use. The parameters used for the assessment of renal functions were serum creatinine and urea concentrations and their clearance. Also, changes in electrolyte concentration of Sodium, Potassium and Chloride concentration were used to assess cardiovascular performance. The histology of the kidney and heart tissues was also done to determine if the extract has impact on the cyto-architecture of the organs. Twenty-four (24) wistar rats were used for the experiment. The rats were grouped randomly into four groups (n = 6). Group 1 served as control, and the rats in the group were given normal rat feeds and water. Group 2 served as low dose group, and rats in this group were administered with low dose of extract 300 mg/kg. Group 3 served as medium group, and rats in this group were treated with medium dose of extract, 450 mg/kg. Group 4 served as high dose group, and rats in this group were treated with high dose of extract 600 mg/kg. The extract was administered for 28 days. Result showed that the extract did not impact negatively on the normal function of the renal and cardiovascular system of the treated groups, rather it enhanced their performances. It can therefore be concluded that the extract is beneficial to renal and cardiovascular functions if used within the treatment dosage.
Perbandingan Metode Jaringan Syaraf Tiruan Pada Klasifikasi Motif Kain Tenun Sambas
Authors: Siregar Alda Cendekia , Octariadi Barry Ceasar
Published: January 2021

Pengolahan citra digital merupakan bagian dari computer vision untuk menganalisa suatu citra atau gambar sehingga menghasilkan suatu informasi yang dapat dipahami manusia. Setiap tahapan dalam pengolahan citra digital memiliki metode masing-masing, untuk citra yang berbeda maka metode yang digunakan juga akan berbeda. Hal ini dikarenakan setiap objek memiliki karakteristik yang berbeda sehingga penggunaan metode perlu menyesuaikan dengan karakteristik citranya. Jaringan syaraf tiruan memiliki kelebihan yaitu sangat fleksibel terhadap data yang memiliki banyak noise, mampu mengklasifikasikan pola, cocok untuk input dan output yang bersifat continue, dapat diimplementasikan dengan mudah di semua aplikasi. Metode jaringan syaraf tiruan juga masih memiliki kekurangan diantaranya parameter terbaik perlu ditentukan secara trial and error, waktu iterasi yang relative lama, dan interpretability yang buruk
Pada penelitian ini akan dilakukan percobaan untuk mendapatkan arsitektur jaringan syaraf tiruan yang optimal. Arsitektur jaringan syaraf tiruan yang akan diujicobakan untuk mendapatkan metode jaringan syaraf tiruan yang optimal untuk data citra kain tenun sambas adalah Backpropagation dan RBF. Akurasi maksimal yang dapat dihasilkan dengan menggunakan JST Backpropagation adalah sebesar 81,33 % dengan parameter nilai learning rate 0,3. Nilai MAE terkecil dihasilkan dari learning rate 0,5 sedangkan nilai RMSE terkecil dihasilkan dari learning rate 0,4. Akurasi maksimal yang dapat dihasilkan dengan menggunakan JST RBF adalah sebesar 88 % dengan parameter nilai learning rate 2. Nilai MAE terkecil dihasilkan dari learning rate 5 sedangkan nilai RMSE terkecil dihasilkan dari learning rate 3. Akurasi yang dihasilkan dari JST RBF lebih tinggi jika dibandingkan dengan JST Backpropagation yaitu 88% dan 81,33% hal ini dapat disimpulkan JST RBF lebih baik dalam mengklasifikasikan citra kain sambas daripada JST Backpropagation