bluuebunny/crossref_metadata_2025 huggingface dataset:
Resveratrol as an anti-asthmatic agent: could this stilbenoid help against COVID-19 in any way? A meta-analysis
Authors:   University of Adiyaman, Parlar Ali , Muñoz-Acevedo Amner ,   Universidad del Norte, Uckardes Fatih ,   Adiyaman University, Jaimes Luisauris ,   Universidad de Santiago de Chile, Aneva Ina ,   Bulgarian Academy of Sciences, Morales Bernardo ,   Universidad de Santiago de Chile, Unis Amina ,   Ras Al Khaimah Medical and Health Sciences University, Rodriguez Maite ,   Andres Bello University, Yumrutas Onder ,   University of Adiyaman, Vinet Raul ,   Universidad de Valparaiso, Bungau Simona ,   University of Oradea, Martinez Jose L. ,   Universidad de Santiago de Chile
Published: May 2021

Resveratrol is a phenolic phytoconstituent found in many plants. This molecule has always caught the attention of scientists because of biological potentials such as inhibition of inflammation, oxidative stress and platelet aggregation as well as to prevent/protect against cardiovascular and neurodegenerative disease/disorders. Literature search have been conducted over resveratrol in covid-19 and asthma studies published in Pubmed and Google Scholars until 30 September 2020. The criteria used in the literature review were determined and were reviewed works on resveratrol including 368 articles and 47 articles on covid-19 and asthma, respectively. As a result of meta-analysis, TNF-α values of the studies showed a significant difference (heterogeneity) of I2=68.39% from each other in total (Cohran Q:6.33, p<0.0423). This study shows that resveratrol would have a potential to reduce ARDS symptoms, by suppressing the cytokine storm and severe inflammation caused by SARS-CoV-2, and by showing strong activity against various types of DNA/RNA viruses.
Ethnobotanical study of the use of medicinal plants in the indigenous Pijao community in Natagaima, Colombia
Authors:   Czech University of Life Sciences, Mendoza Hernandez Amilkar Hernando , Niño Hernandez Miguel Angel ,   Universidad de Cundinamarca, Chaloupkova Petra ,   Czech University of Life Sciences, Fernandez-Cusimamani Eloy ,   Czech University of Life Sciences
Published: May 2021

Semi-structured interviews (80) were applied in order to document the medicinal plants used by the Pijao indigenous community in Natagaima, Colombia. As a result, a total of 110 species distributed in 54 families were registered, Asteraceae and Fabaceae (9% each) being the most important families. Regarding the parts of the plant, the most used structure was leaves (46.7%), the main form of preparation was infusion (32%), and the most used way of administration was oral (77.8%). The value of use of the species by informants (VUis), the relative importance of medicinal species (IRE) and the index of cultural value of medicinal species (IVUs) were determined. The most important species according to their value of use were: Tamarindus indica L., Psidium guajava L., Mentha x piperita L., Moringa oleifera Lam. The most reported ailments were gastrointestinal problems such as stomach pain and diarrhea, general aches, headache, fever, swollen liver, and respiratory problems.
Oncofertility in Canada: cryopreservation and alternative options for future parenthood
Authors: Ronn R. , Holzer H.E.G.
Published: May 2021

Cancer can be a devastating diagnosis. In particular, malignancy and its indicated treatments have profoundly negative effects on the fertility of young cancer patients. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer therapies and to facilitate fertility preservation. In Canada, these fertility issues are often inadequately addressed despite the availability of resources. The goal of this four-part series is to facilitate systemic improvements in fertility preservation for adolescent and young adult Canadians with a new diagnosis of cancer. This article reviews fertility preservation options that use cryopreservation techniques. It also outlines some of the alternative options for future parenthood. Cryopreservation of a woman’s gametes and gonadal tissue may involve embryo, oocyte, and ovarian tissue cryopreservation with or without ovarian stimulation. Similarly, male gametes and gonadal tissue may be cryopreserved. Techniques and success rates continue to improve. Third-party assistance through gamete donation, gestational carriers, and adoption are also alternative options for parenthood. Cryopreservation techniques are especially feasible options for fertility preservation in the newly diagnosed cancer patient.
Pemanfaatan Limbah Cucian Beras Hitam Sebagai Pupuk Organik Cair Terhadap Tanaman Sawi Hijau (Brassica juncea L)
Authors: Murdaningsih Murdaningsih , Hutubessy Josina Irene Brigetha , Hurint Albertus M.T
Published: May 2021

This study aims to determine the application dose of liquid organic fertilizer from black rice wastewater on the growth and yield of mustard greens. The research was carried out at the Experimental Garden of the Faculty of Agriculture, the University of Flores for 6 months from June to November. The research was carried out using a randomized block design consisting of 6 doses of black rice liquid waste (Liquid Organic Fertilizer: LOF), namely: P0 = without LOF, P1 = 2,400 ltr/ha = 750 ml/plot; P2: 4800 ltr/ha = 1500 ml/plot; P3: 7200 ltr/ha = 2250 ml/plot; P4: 9600 ltr/ha = 3000 ml/plot; P5: 1200 ltr/ha = 3750 ml/plot; which was repeated 4 times, so there were 24 experimental experiments. The application of liquid organic fertilizer from black rice liquid waste to mustard greens showed an average response to an increase in plant height of 5.08%, leaf number of 7.95% and leaf area of 17.59%. The yield uptake variable was 11.51%, and the application dose of 9600 ltr/ha gave a plant height of 46.41 cm, a number of leaves 8.25, leaf area 1691.35 cm2, and fresh weight of mustard greens tan-1 of 153.65 and the weight of mustard ha-1 was 24.58 tonnes, but not significantly different from P3 (7200 ltr/ha).
Finding One’s Place in a Host Space: A Small-Scale Study of Cultural Integration and Language Maintenance Among Croatian Immigrants in Canada
Authors: Škifić Sanja , Strika Antonia
Published: May 2021

This paper focuses on sociocultural and language-related issues among Croatian immigrants in Canada. It presents the results of thestudy conducted from November 2018 to February 2019 among Croatian immigrants of different generations in Ontario and British Columbia. Questions included in the questionnaire refer to different aspects of participants’ identity and their (families’) immigration, as well as issues related to their attitudes towards the homeland and engagement in Croatian associations in Canada. Participants were asked to provide feedback on their language acquisition, competence and use, as well as evaluations of the importance of the Croatian language for their identity. The questionnaire also contained questions related to participants’ language use from emotional and cognitive perspectives. Conclusions drawn on the basis of the collected data provide an insight into Croatian immigrants’ language use, the extent of cultural integration and language maintenance, and their attitudes towards the relationship between identity and language.
Vol. IX, nº 1 (invierno 2021)
Authors: Pasavento Redacción
Published: May 2021

Portada e índice
Historia y política en dos novelas de Patricio Pron: "El comienzo de la primavera" y "No derrames tus lágrimas por nadie que viva en estas calles"
Authors: Castillo José Luis
Published: May 2021

Este artículo estudia dos novelas del escritor argentino Patricio Pron, El comienzo de la primavera (2008) y No derrames tus lágrimas por nadie que viva en estas calles (2014), agrupadas por su temática común: la evolución histórico política de Europa desde la Segunda Guerra Mundial y, más en concreto, las consecuencias del extremismo ideológico para Alemania e Italia. Partiendo de las ideas de Roberto Esposito, Walter Benjamin y Giorgio Agamben, entre otros, se analizan dos aspectos centrales en ambas novelas: el sentido de la historia y su relación con la responsabilidad individual ante el pasado, y la dicotomía entre ética y política. Ambas novelas despliegan un realismo analítico que experimen ta con las estructuras narrativas y la perspectiva para dar cuenta de qué significa construir una conciencia política en el siglo XXI.
El papel del autor y la condición testimonial de las novelas "No, mi general" de Irene Lozano y "Hay algo que no es como me dicen" de Juan José Millás
Authors: Lilic Milica
Published: May 2021

El presente trabajo parte del concepto de la novela testimonial y sus manifestaciones en la narrativa española actual, para analizar los elementos documentales y las técnicas ficcionales integradas en las obras No, mi general de Irene Lozano y Hay algo que no es como me dicen de Juan José Millás. El cambio en el enfoque temático que presentan estas novelas –ambas relatan historias reales sobre el acoso laboral y sexual a las mujeres en el Ejército español y el Ayuntamiento de Ponferrada, respectivamente–, permitirá estudiar su estructura particular, así como la importancia del papel del autor y su intervención real y parcial en el caso. De esta forma, se afirmará el carácter colectivo y denunciante de estas obras en cuanto a la mencionada problemática social emergente. Asimismo, se pondrá énfasis especial en la subjetivización, elemento que demuestra la condición testimonial de estas novelas, esto es, afirma el desarrollo de una serie de técnicas que objetivizan los hechos, por una parte, y certifica la presencia de los mecanismos que aportan a la narrativización del relato, por otra. Finalmente, se distinguirán dos niveles de narración: la historia de la protagonista y la historia del narrador. La primera narra un caso real de acoso desde la perspectiva de la víctima, esto es, reinterpreta la verdad oficial y reconstruye la realidad, mientras que la segunda adquiere una dimensión modélica y apela a todo un colectivo de mujeres acosadas en el lugar de trabajo.
Una lectura de la capital de Cataluña: urbanismo, violencia y la ciudad como organismo en "Barcelona trágica" de Andreu Martín
Authors: Martínez-Samos Agustín
Published: May 2021

La novela Barcelona trágica (2009) de Andreu Martín nos muestra un episodio de incertidumbre política, de desobediencia civil y de violencia urbana, conocido históricamente como “La Setmana Tràgica de Barcelona”, que se desarrolla en la urbe barcelonesa durante el verano de 1909. En el presente estudio se examina con profundidad la visión de la capital de Cataluña como un organismo vivo y dañado en constante metamorfosis, que expone un extenuante proceso de colisión y ajuste social para puntualizar la inacabada realización de la subjetividad personal y colectiva. El trabajo señala la existencia de vínculos históricos inestables y antagónicos entre el espacio urbano global y la multiplicidad de espacios fronterizos, utilizados por la burguesía industrial como estructuras minimizadoras capaces de alterar y alienar la maltrecha existencia del incipiente proletariado anarquista. Se reflexiona como lo urbano en la narrativa de Martín se transforma en un versátil barómetro de las alteraciones públicas y de los problemas de clase acaecidos para reevaluar el binomio ciudadano-sociedad. De este modo, a través de la observación crítica de las estrategias propias de la ficción, se discurre como el individuo sufre innegables y nefastas consecuencias debido a las múltiples negociaciones y a las relaciones asimétricas entre Barcelona y sus ciudadanos, reflejo del entorno metropolitano agreste producto de la crisis política y social de 1909.
HUBUNGAN KEPEMIMPINAN TRANSFORMATIONAL, KOMPENSASI DAN KOMPETENSI TERHADAP KINERJA PEGAWAI PADA DINAS PENDIDIKAN ACEH
Authors: Rahmi Amelia , Yufdiar Muhammad Yudi
Published: May 2021

Rumusan masalah dalam penelitian ini adalah seberapa besar pengaruh kepemimpinan tranformasional secara parsial terhadap kinerja pegawai pada Dinas Pendidikan Aceh? Seberapa besar pengaruh kompensasi secara parsial terhadap kinerja pegawai pada Dinas Pendidikan Aceh? Seberapa besar pengaruh kompetensi secara parsial terhadap kinerja pegawai pada Dinas Pendidikan Aceh? Seberapa besar pengaruh kepemimpinan tranformasional, kompensasi, dan kompetensi secara simultan terhadap kinerja pegawai pada Dinas Pendidikan Aceh? Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan tranformasional terhadap kinerja pegawai pada Dinas Pendidikan Aceh, untuk mengetahui pengaruh kompensasi terhadap kinerja pegawai pada Dinas Pendidikan Aceh, untuk mengetahui pengaruh kompetensi terhadap kinerja pegawai pada Dinas Pendidikan Aceh. untuk mengetahui pengaruh kepemimpinan tranformasional, kompensasi dan kompetensi secara simultan terhadap kinerja pegawai pada Dinas Pendidikan Aceh. Analisis data yang digunakan dalam penelitian ini adalah metode analisis regresi linier berganda yang sampel dalam penelitian adalah pegawai yang bekerja pada Dinas Pendidikan Aceh sebayak 77 responden. Hasil penelitian ini menunjukan bahwa kepemimpinan tranformasional secara parsial berpengaruh terhadap kinerja pegawai pada Dinas Pendidikan Aceh, kompensasi secara parsial tidak berpengaruh terhadap kinerja pegawai pada Dinas Pendidikan Aceh, kompetensi secara parsial berpengaruh terhadap kinerja pegawai pada Dinas Pendidikan Aceh. Secara simultan kepemimpinan tranformasional, kompensasi dan kompetensi berpengaruh terhadap kinerja pegawai pada Dinas Pendidikan Aceh
PENGARUH KEPUASAN KERJA, LINGKUNGAN KERJA, DAN PEMBERIAN INSENTIF TERHADAP PRESTASI KERJA KARYAWAN PADA PT. PEGADAIAN (PERSERO) CABANG BANDA ACEH
Authors: Yusuf Yuslaidar , Dewi Nelva
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh Kepuasan Kerja, Lingkungan Kerja, dan Pemberian Insentif terhadap Prestasi Kerja karyawan PT. Pegadaian (persero) Cabang Banda Aceh. Populasi penelitian adalah seluruh karyawan PT. Pegadaian (persero) Cabang Banda Aceh dengan jumlah 36 orang karyawan. Teknik pengambilan sampel pada penelitian ini menggunakan Teknik Sampel Jenuh atau lebih dikenal dengan istilah sensus dimana keseluruhan populasi dijadikan sebagai sampel. Data penelitian ini dikumpulkan melalui daftar kuesioner dan studi dokumentasi. Pengujian hipotesis menggunakan Analisis Regresi Linear Berganda dengan bantuan program SPSS 21. Uji F(simultan) dan uji t (parsial) dimaksud untuk mengetahui pengaruh variabel independen terhadap variabel dependen pada tingkat kepercayaan 95% (ɑ = 0.05). Hasil penelitian menunjukkan bahwa secara uji simultan antara Kepuasan Kerja, Lingkungan Kerja, Dan Pemberian Insentif berpengaruh terhadap Prestasi Kerja Karyawan Pada PT. Pegadaian (Persero) Syariah Cabang Banda Aceh. Kemudian secara parsial yaitu Kepuasan Kerja, Lingkungan Kerja, Dan Pemberian Insentif berpengaruh terhadap Prestasi Kerja Karyawan PT. Pegadaian (Persero) Cabang Banda Aceh.
PENGARUH BUDAYA KERJA DAN DISIPLIN KERJA TERHADAP PRESTASI KERJA KARYAWAN PT. JASA RAHARJA (PERSERO) CABANG ACEH
Authors: Tuwisna Tuwisna , Sulfitra Sulfitra , Sahara Yuni
Published: May 2021

Permasalahan dalam penelitian ini adalah pengaruh Budaya Kerja dan Disiplin Kerja terhadap Prestasi Kerja Karyawan Pada PT. Jasa Raharja (Persero) Cabang Aceh. Tujuan dalam penelitian ini adalah Untuk mengetahui pengaruh Budaya Kerja dan Disiplin Kerja terhadap Prestasi Kerja Karyawan Pada PT. Jasa Raharja (Persero) Cabang Aceh. Jumlah sampel penelitian ini sebanyak 78 responden Data penelitian dikumpulkan melalui kuisioner, dan studi dokumentasi. Pengujian hipotesis menggunakan analisis regresi linier berganda, uji F dan uji t dimaksud  untuk mengetahui secara simultan dan secara parsial pengaruh variabel independen terhadap variabel dependen pada tingkat kepercayaan 95% (α = 0,05). Hasil penelitian berdasarkan uji simultan menunjukan bahwa variabel Budaya Kerja dan Disiplin Kerja berpengaruh signifikan terhadap Prestasi Kerja Karyawan Pada PT. Jasa Raharja (Persero) Cabang Aceh. Sedangkan secara parsial variabel Budaya Kerja dan Disiplin Kerja berpengaruh signifikan terhadap Prestasi Kerja Karyawan Pada PT. Jasa Raharja (Persero) Cabang Aceh.
PENGARUH CITRA MEREK DAN PENGALAMAN PELANGGAN TERHADAP PENGGEMAR MEREK KOSMETIK WARDAH DI KOTA BANDA ACEH
Authors: Erlinda Erlinda
Published: May 2021

Penggemar merek adalah bentuk  perilaku konsumen yang lebih kuat dari loyalitas dan merupakan variabel yang relatif baru dalam bidang pemasaran. Penggemar merek diukur melalui indikator kesetiaan merek, kesesuaian citra diri, dan keterlibatan. Penelitian ini ditujukan untuk menguji pengaruh citra merek dan pengalaman pelanggan terhadap penggemar merek kosmetik Wardah di kota Banda Aceh. Menggunakan pendekatan kausalitas – eksplanatory dengan data primer melalui persepsi, opini dan sikap dari 96 responden sebagai objek penelitian individual. Metode pengumpulan data adalah survei menggunakan kuesioner. Dimensi waktu adalah studi satu titik waktu. Analsis jalur digunakan untuk menganalisis data, menggunakan SPSS versi 22.  Hasil penelitian menunjukkan bahwa citra merek dan pengalaman pelanggan berpengaruh signifikan terhadap penggemar merek. Pengaruh pengalaman pelanggan lebih besar dari citra merek dalam mempengaruhi penggemar merek
STRATEGI PEMASARAN RUMAH SAKIT TEUNGKU FAKINAH BANDA ACEH DALAM MENINGKATKAN KEUNGGULAN BERSAING
Authors: Chalil Muhamad , Yusuf Yuslaidar
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh strategi pemasaran terhadap keunggulan bersaing pada Rumah Sakit Teungku Fakinah Banda Aceh.Penelitian ini merupakan penelitian satu waktu (one shoot study) yaitu penelitian yang datanya dikumpulkan sekaligus dapat berupa data dari subyek penelitian dalam satu periode waktu. Penelitian ini menggunakan desain surveydenganjenis penelitianpenelitiankausalyang bertujuan untuk meneliti  hubungan  sebab-akibat  antara  dua variabel  atau  lebih.Sampel dalam penelitian ini adalah sebanyak 99 orang karyawan pada Rumah Sakit Teungku Fakinah Banda Aceh. Metode pengambilan sampel menggunakan accidental non random sampling dimana responden diperoleh saat dilakukannya penelitian.Analisis data yang digunakan dalam penelitian ini adalah metode analisis regresi linier sederhana.Hasil penelitian menunjukkan bahwa strategi pemasaran (X) berpengaruh positif dan signifikan terhadap terhadap keunggulan bersaing (Y).
PENGARUH BUDAYA KERJA DAN KOMITMEN TERHADAP KINERJA PEGAWAI NEGERI SIPIL (PNS) PADA KANTOR WALIKOTA BANDA ACEH
Authors: Sharlina Nila , Murni Mirza
Published: May 2021

Tujuan Penelitian ini adalah Untuk mengetahui seberapa besar pengaruh budaya kerja terhadap kinerja pegawai Negeri Sipil (PNS) pada kantor Walikota Banda Aceh, Untuk mengetahui seberapa besar pengaruh komitmen terhadap kinerja pegawai Negeri Sipil (PNS) pada kantor Walikota Banda Aceh, dan Untuk mengetahui seberapa besar pengaruh budaya kerja dan komitmen terhadap kinerja Pegawai Negeri Sipil (PNS) pada Kantor Walikota Banda Aceh. Ukuran sampel penelitian ini sebanyak 99 Pegawai Negeri Sipil (PNS). Data penelitian dikumpulkan melalui daftar pertanyaan/kuesioner dan studi dokumentasi. Pengujian hipotesis menggunakan analisis linier berganda yang diolah menggunakan program  SPSS (Statistical Package for the Social Sciences) 20.0. Hasil penelitian secara parsial menunjukkan bahwa budaya kerja berpengaruh signifikan terhadap kinerja Pegawai Negeri Sipil (PNS) pada kantor Walikota Banda Aceh, sedangkan komitmen tidak berpengaruh signifikan terhadap kinerja Pegawai Negeri Sipil (PNS) pada Kantor Walikota Banda Aceh. Dan hasil penelitian secara simultan menunjukkan bahwa budaya kerja dan komitmen secara bersama-sama memiliki pengaruh yang positif dan signifikan terhadap kinerja pegawai Negeri Sipil (PNS) pada Kantor Walikota Banda Aceh
PENGARUH E-COMMERCE TERHADAP MINAT BERWIRAUSAHA YANG DIMODERASI OLEH PENDIDIKAN KEWIRAUSAHAAN (STUDI KASUS PADA MAHASISWA FAKULTAS EKONOMI UNIVERSITAS MUHAMMADIYAH ACEH)
Authors: Erlinda Erlinda , Astuti Rika
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh e-commerce terhadap minat berwirausaha yang dimoderasi oleh pendidikan kewirausahaan pada mahasiswa Fakultas Ekonomi Universitas Muhammadiyah Aceh, dengan sampel sebanya 95 mahasiswa. Metode analisis data menggunakan regresi linear sederhana guna memastikan signifikansi pengaruh e-commerce terhadap minat berwirausaha. Selanjutnya   metode moderated regression analysis digunakan untuk melihat pengaruh variabel moderasi pendidikan kewirausahaan terhadap minat berwirausaha mahasiswa Fakultas Ekonomi Universitas Muhammadiyah Aceh. Hasil penelitian menunjukkan bahwa e-commerce secara partial berpengaruh positif dan signifikan terhadap minat berwirausaha. Pendidikan    kewirausahaan secara signifikan memederasi dan memperkuat pengaruh e-commerce terhadap minat berwirausaha mahasiswa Fakultas Ekonomi Universitas Muhammadiyah Aceh.
Türkiye Diplomasisi Bağlamında Çevirmenin Görünürlüğü: Milletler Cemiyeti Dönemi (1919 - 1939)
Authors: FİLAZİ Ensa
Published: May 2021

Çevirmenlik mesleği, uluslararası iletişim ve işbirliği sağlamada önemli bir konuma sahiptir ve uluslararası sahada her zaman etkili bir biçimde var olmuştur. Bu çalışmada çevirmenlik mesleğinin tarihsel gelişiminde mühim bir alan olan diplomasi bağlamında çevirmenin kazandığı anlama ve çevirmenlik mesleğinin görünürlük sürecine yönelik saptamalar yapılmıştır. Diplomaside, çevirmenlik etkili bir rol oynamaktadır. Uluslararası ilişkilerin yürütülmesi farklı dilleri konuşan ülkelerin diplomatlarının bir araya gelmesini gerekli kılmaktadır. Bu itibarla diplomasi tarihi, çeviri tarihinin önemli bir aşamasını oluşturmaktadır. Bunun en iyi örneği 20. yüzyılın başlarında ilk evrensel örgüt olan Milletler Cemiyeti dönemidir. I. Dünya Savaşı’ndan sonra diplomatik görüşmelerin yoğunluk kazandığı bilinmektedir. Uluslararası ilişkilerin artmasıyla birlikte “çevirmenliğin” bir meslek olarak geliştiği ve diplomasi alanında da çeviri etkinliğinin ön plana çıktığı söylenebilir. Bu çalışmada, çevirmenin konumu, görünürlüğü ve mesleki gelişimi Milletler Cemiyeti özelinde değerlendirilmiştir. Günümüzde çevirmenlik mesleğinin Türkiye’de gereken ilgiye ulaşamamasının sebebini açıklayabilmek için 1919-1939 yılları arasındaki çeviri tarihi çalışmaları kronolojik biçimde ele alınmış ve diplomatik çeviriye yönelik yeterli kaynağın olmadığı saptanmıştır. Aynı zamanda uluslararası ilişkiler konulu bazı tarih kaynakları incelenmiş ve bu kaynaklarda çevirmenlikle ilgili yeterli bilgiye yer verilmediği tespit edilmiştir. Bu bağlamda diplomasi tarihi araştırmacılarının çeviri tarihine yönelik yeni araştırmalar yapması, diplomasi tarihçileriyle çeviri tarihçilerinin işbirliği içinde bulunması önem arz etmektedir. Çalışmanın Türkiye’de çevirmenlik mesleğinin somut görünürlüğünün artmasına katkıda bulunacağı düşünülmektedir.
Switch from Infliximab to Infliximab-dyyb for Rheumatology Indications
Authors: Spoto Alexi , Pitcher Katie , Hui Rita , Lautchang Aeris
Published: May 2021

Introduction
Multiple expert panels at Kaiser Permanente approved infliximab-dyyb (Inflectra®), a biosimilar to the reference product infliximab (Remicade®), to be the preferred infliximab agent for therapeutic substitution from infliximab for adult patients with dermatologic, rheumatologic, and/or gastroenterologic diagnoses. The objective of this study was to assess the safety and effectiveness of infliximab-dyyb for Kaiser Permanente Northern California patients with psoriatic and rheumatoid arthritis who switched from infliximab to infliximab-dyyb.
Methods
This was an observational, data-only, non-inferiority study assessing adult patients with a rheumatologic condition of psoriatic arthritis (PsA) or rheumatoid arthritis (RA) who were switched from infliximab to infliximab-dyyb or used infliximab continuously in the Northern California region of Kaiser Permanente from May 2017 through May 2018. Both groups were followed for 12 months. The primary effectiveness outcome was disease worsening requiring acute care defined as emergency room visit or hospitalization related to the rheumatologic condition or orthopedic surgery intervention. Non-inferiority was set at an upper limit of 4%.
Results
A total of 70 individuals were identified as continuing infliximab and 727 individuals were switched to infliximab-dyyb. There were 2 patients (2.9%) in the infliximab group and 22 patients (3.0%) in the infliximab-dyyb group who experienced disease worsening requiring acute care (P = 0.03 for non-inferiority).
Conclusion
There was no increased risk of disease worsening requiring acute care in patients with RA or PsA who switched from infliximab to infliximab-dyyb when compared to patients who remained on infliximab in this population.
Assessment of the Implementation of Pharmacists’ Prescriptive Authority to Furnish Hormonal Contraceptives, Naloxone, and Nicotine Replacement Therapy in California
Authors: Petrosyan Janet , Tchalikian Tina , O'Connor Alicia , Avakeretyan Juliana , Dykhne Marina
Published: May 2021

Background
California State Board of Pharmacy passed Senate Bill 493 authorizing pharmacists to furnish self-administered hormonal contraceptives, nicotine replacement products, and naloxone. Although California Senate Bill 493 expanded pharmacists’ scope of practice, limited implementation persists.
Objective
The objectives of this study were to assess the implementation of pharmacists’ prescriptive authority to furnish hormonal contraceptives, naloxone, and NRT in California as allowed by the Board of Pharmacy and availability of these services to patients in order to facilitate the development of strategies to expand them. The objective of the first part was to investigate reported awareness and barriers to implementation of services, while the second part was to report actual implementation rates.
Methods
This was an IRB-approved two-part cross-sectional survey that explored factors that may be associated with the limited implementation of the expanded scope of practice services.
Results
The two-part study had a total of 389 respondents. In the first part of the study, there were a total of 84 respondents. The majority reported that they were aware that pharmacists have the authority to furnish hormonal contraceptives, naloxone, and NRT, but services were limited. In the second part of the study, there were a total of 305 respondents, each responding to questions addressing only one of the three services: hormonal contraceptives (104 respondents), naloxone (101 respondents), and NRT (100 respondents). Within those subgroups, 19% of the respondents stated they offer hormonal contraceptives, 10% offer NRT, and 84% offer naloxone.
Conclusion
The results of the two-part study suggested that pharmacists’ authority to furnish these services were limited, thus patients’ access to these services were also limited.
Perceptions and Attitudes of Pharmacogenomics Through the Lens of Community Pharmacists and Patients
Authors: Surofchy Dalga , Mnatzaganian Christina , Sarino Lord , Kuo Grace
Published: May 2021

Background
Pharmacists represent some of the most accessible healthcare workers and are in an opportune position to spearhead new clinical initiatives, such as pharmacogenomics (PGx) services. It is important that we understand the perceptions and attitudes both pharmacists and patients have regarding PGx and potential barriers of implementing it into routine clinical practice.
Methods
A cross-sectional survey study was conducted across one regional division of a large community pharmacy chain to assess the perceptions and attitudes of pharmacists and patients regarding PGx in California. A secondary aim was to determine perceived barriers to PGx implementation into community pharmacies.
Results
The majority (67%) of pharmacists agreed or strongly agreed to understanding PGx compared to 35% of patients being aware of PGx (p<0.001). More patients (62%) preferred their pharmacist compared to pharmacists (43%) preferring themselves as a provider to manage patients' medications based on their PGx results (p<0.01). Many patients (88%) expressed interest in participating in a PGx test; both pharmacists (84%) and patients (85%) were unlikely to have participated or know someone who has participated in PGx testing. Pharmacists and patients expressed similar concerns about privacy of their PGx data by employers (p=0.287) and insurers (p=0.953), a potential barrier to PGx implementation.
Conclusion
Pharmacists are well positioned to spearhead PGx consultations and patients are interested in pharmacists using PGx to help manage their medications; however, various barriers were identified that must be overcome for PGx to become incorporated in routine practice.
Tempat Sampah Pintar Berbasis Internet of Things (IoT) Dengan Sistem Teknologi Informasi
Authors: Ismail Mualief , Abdullah Riska K. , Abdussamad Syahrir
Published: May 2021

Mengangkat dari permasalahan sampah yang berserakan di sekitar area tong sampah, permasalahan tersebut kini dapat di tangani dengan sebuah penelitian tentang tempat sampah pintar. Metode yang digunakan adalah eksperimen dan perancangan dimana pengujian dilakukan terhadap jarak sensor, ketinggian sampah dan respon data terhadap web server. Tempat sampah ini menggunakan teknologi raspberry pi dan internet of things (IoT) yang bersifat berbasis website.  Sistem akan dibuat dari rangkaian pendukung yaitu, sensor HC-SR04 sebagai pendeteksi objek dan data sampah. Sementara itu, pada output di gunakan motor servo sebagai penggerak penutup tong sampah, selain itu terdapat Web server sebagai pengecekan data sampah dari jarak jauh. Pada bagian selanjutnya terdapat pula output berupa LED sebagai pemberi tahu keadaan tong sampah ketika penuh atau kosong secara langsung. Hal ini dapat membantu tingkat kesadaran masyarakat dalam hal membuang sampah tidak pada tempatnya. Hasil yang diperoleh dalam penelitian ini adalah buka tutup tong sampah dengan setingan perangkat lunak      lebih kecil dari 60 cm terbuka dan lebih besar dari 60 cm tidak terbuka. Selanjutnya hasil pendeteksia sensor terhadap level sampah 8 cm level penuh, 21-28 cm level setengah dan 48 cm level kosong. Dan hasil pengiriman data ke web server semua level sampah terdeteksi sudah sesuai. Taking the problem of garbage scattered around the trash can area, this problem can now be handled with a study on smart trash cans. The method used is experimental and design where testing is carried out on sensor distance, waste height and data response to the web server. This trash can uses raspberry pi technology and internet of things (IoT) which is website-based. The system will be made from a series of supports, namely the HC-SR04 sensor as object detection and garbage data. Meanwhile, at the output, a servo motor is used to drive the trash can cover, besides that there is a Web server for checking waste data remotely. In the next section there is also an output in the form of an LED as a direct notification of the state of the trash can when it is full or empty. This can help the level of public awareness in terms of disposing of waste inappropriately. The results obtained in this study are open and close trash cans with software settings smaller than 60 cm open and larger than 60 cm not open. Furthermore, the sensor detection results for the waste level of 8 cm full level, 21-28 cm half level and 48 cm empty level. And the results of sending data to the web server, all levels of waste detected are appropriate.
Rancang Bangun Alat Peringatan Dini Dan Informasi Lokasi Kebakaran Berbasis Arduino Uno
Authors: Nento Novaldiyanto K. , Asmara Bambang Panji , Nasibu Iskandar Zulkarnain
Published: May 2021

Bahaya  kebakaran  adalah  bahaya  yang  diakibatkan  oleh  adanya  ancaman  potensial  dan  derajat terkena  pancaran  api  sejak  dari  awal  terjadi  kebakaran  hingga  penjalaran  api,  asap  dan  gas  yang ditimbulkan. Kebakaran adalah terjadinya api yang tidak dikehendaki. Proses informasi adanya kebakaran pada umumnya masih memakai cara manual, hal ini dilakukan karena belum memanfaatkan kecanggihan teknologi yang sekarang ini sangat berkembang pesat. Informasi kebakaran ini kurang cepat dan tepat khususnya pada satuan pemadam kebakaran. Tujuan dari penelitian ini adalah merancang sistem yang dapat digunakan untuk menginformasikan kebakaran dengan cepat beserta informasi lokasi pada tempat terjadinya kebakaran. Metode yang digunakan dalam penelitian ini yaitu metode eksperimen dan perancangan baik dalam pembuatan perangkat keras serta perangkat lunak pendukungnya. Perangkat kerasnya menggunakan sensor api, sensor asap dan sensor suhu, dan menginformasikan melalui modul GSM serta modul GPS untuk membaca koordinat lokasi kebakaran. Hasil dari perancangan alat peringatan dini dan informasi lokasi kebakaran berbasis arduino uno bekerja dengan baik. Pada alat pengirim, saat kondisi ada api, ada asap dan suhu diatas 50 derajat alat mengirimkan sms untuk menyalakan alat penerima dan sms link google maps lokasi kebakaran. Pada alat penerima, saat alat menerima sms dari alat pengirim, alat akan menyalakan buzzer. Alat bekerja sesuai dengan yang telah direncanakan dan bisa digunakan untuk mendeteksi adanya kebakaran. Fire hazard is a danger that is caused by the potential threat and the degree of exposure to fire from the start of a fire to the spread of fire, smoke, and the gas it causes. Fire is a fire incident that is not desired. In general, the information process for fires still uses the manual method, this is done because it has not taken advantage of the sophistication of technology which is now very rapidly developing. This fire information is not fast and accurate, especially for fire fighting units. The purpose of this research is to design a system that can be used to quickly inform fires along with location information at the scene of the fire. The method used in this research is the experimental method and design both in hardware and supporting software. The hardware uses fire sensors, smoke sensors, and temperature sensors, and informs via GSM module as well as the GPS module to read the coordinates of the fire location. The results of the design of early warning tools and fire location information based on Arduino Uno worked well. On the sending device, when there is a fire, there is smoke and the temperature is above 50 degrees, the device sends an SMS to the receiving device and the SMS link on the google maps location of the fire. On the receiving device, when the device receives an SMS from the sending device, the device will create a buzzer. The tool works as planned and can be used to check for fires.
Kurzfassungen der Vorträge und Poster der 21. Wissenschaftlichen Tagung
der Österreichischen Pharmazeutischen Gesellschaft (ÖPhG), 16. bis 18. April
2009, Wien, Österreich
Authors:   Scientia Pharmaceutica
						Editorial Office
Published: May 2021

n/a
3D Morphology of Open Clusters in the Solar Neighborhood with Gaia EDR 3: Its Relation to Cluster Dynamics
Authors: Pang Xiaoying , Li Yuqian , Yu Zeqiu , Tang Shih-Yun , Dinnbier František , Kroupa Pavel , Pasquato Mario , Kouwenhoven M. B. N.
Published: May 2021

We analyze the 3D morphology and kinematics of 13 open clusters (OCs) located within 500 pc of the Sun, using Gaia EDR 3 and kinematic data from the literature. Members of OCs are identified using the unsupervised machine-learning method StarGO, using five parameters (X, Y, Z,

). The OC sample covers an age range of 25 Myr to 2.65 Gyr. We correct the asymmetric distance distribution that is due to parallax error using Bayesian inversion. The uncertainty in the corrected distance for a cluster at 500 pc is 3.0–6.3 pc, depending on the intrinsic spatial distribution of its members. We determine the 3D morphology of the OCs in our sample and fit the spatial distribution of stars within the tidal radius in each cluster with an ellipsoid model. The shapes of the OCs are well described with oblate spheroids (NGC 2547, NGC 2516, NGC 2451A, NGC 2451B, and NGC 2232), prolate spheroids (IC 2602, IC 4665, NGC 2422, Blanco 1, and Coma Berenices), or triaxial ellipsoids (IC 2391, NGC 6633, and NGC 6774). The semimajor axis of the fitted ellipsoid is parallel to the Galactic plane for most clusters. Elongated filament-like substructures are detected in three young clusters (NGC 2232, NGC 2547, and NGC 2451B), while tidal-tail-like substructures (tidal tails) are found in older clusters (NGC 2516, NGC 6633, NGC 6774, Blanco 1, and Coma Berenices). Most clusters may be supervirial and expanding. N-body models of rapid gas expulsion with a star formation efficiency of ≈1/3 are consistent with clusters more massive than 250 M
⊙, while clusters less massive than 250 M
⊙ tend to agree with adiabatic gas expulsion models. Only five OCs (NGC 2422, NGC 6633, NGC 6774, Blanco 1, and Coma Berenices) show clear signs of mass segregation.
On the Hubble Constant Tension in the SNe Ia Pantheon Sample
Authors: Dainotti M. G. , De Simone B. , Schiavone T. , Montani G. , Rinaldi E. , Lambiase G.
Published: May 2021

The Hubble constant (H
0) tension between Type Ia supernovae (SNe Ia) and Planck measurements ranges from 4 to 6σ. To investigate this tension, we estimate H
0 in the ΛCDM and

w

0

w

a

CDM (cold dark matter) models by dividing the Pantheon sample, the largest compilation of SNe Ia, into 3, 4, 20, and 40 bins. We fit the extracted H
0 values with a function mimicking the redshift evolution:

g

(
z
)
=

H

0

(
z
)
=

H

˜

0

/

(
1
+
z
)

α

, where α indicates an evolutionary parameter and

H

˜

0

=

H

0

at z = 0. We set the absolute magnitude of SNe Ia so that

H

0

=
73.5

km

s

−
1

Mpc

−
1

, and we fix fiducial values for

Ω

0
m

Λ
CDM

=
0.298

and

Ω

0
m

w

0

w

a

CDM

=
0.308

. We find that H
0 evolves with redshift, showing a slowly decreasing trend, with α coefficients consistent with zero only from 1.2 to 2.0σ. Although the α coefficients are compatible with zero in 3σ, this however may affect cosmological results. We measure locally a variation of

H

0

(
z
=
0
)
−

H

0

(
z
=
1
)
=
0.4

km

s

−
1

Mpc

−
1

in three and four bins. Extrapolating

H

0

(
z
)

to z = 1100, the redshift of the last scattering surface, we obtain values of H
0 compatible in 1σ with Planck measurements independent of the cosmological models and number of bins we investigated. Thus, we have reduced the H
0 tension in the range from 54% to 72% for both cosmological models. If the decreasing trend of

H

0

(
z
)

is real, it could be due to astrophysical selection effects or to modified gravity.
Characteristics of an Extreme Dusty Star-forming Galaxy at z = 4.5
Authors: Chan Alyssa , Long Arianna S. , Cooray Asantha R.
Published: May 2021

We present new physical properties for an extreme (L
IR > 1013
L
⊙), unlensed dusty star-forming galaxy at z = 4.531, G09-81106. We compile fluxes from the literature, and include new Hubble Space Telescope data to generate SED models under various assumptions. G09-81106 has a number of physical characteristics that far surpass the average data for DSFGs, including high dust temperature (∼70 K) and star formation rate ( > 2 × 103
M
⊙ yr−1). While barely within the average star-forming main sequence region, G09 is already an order of magnitude more massive and more star-forming than most star-forming galaxies at similar epochs. Visual inspection suggests these exceptional properties may be due to an ongoing merger, though future work with spatially resolved imaging and spectroscopic analysis will reveal its true nature.
Determinants of small-scale farmers’ intention to adopt insect farming for animal feed in Colombia
Authors: Diaz S. Espinosa , Speelman S. , Moruzzo R. , De Steur H.
Published: May 2021

While it is recognised that insect farming as an alternative feed production system can yield substantial benefits for rural communities, farmers will ultimately have to decide whether to adopt these systems or not. This study aims to understand the factors that influence the intention of farmers to adopt insect farming for animal feed in the context of a developing country. Building upon two well-established theories (theory of planned behaviour and technology acceptance model), a survey was administered with 100 small-scale farmers in the region of Santander, Colombia. Findings demonstrate that the majority of farmers are positively oriented towards the implementation of this alternative feed production strategy. Both psychological and technology-oriented aspects related to this innovative practice play a crucial role in decision-making of small-scale farmers. Thereby, adoption intention was mainly determined by their subjective norms and perceived ease of use, with education and importance of feed attributes as significant external variables.
Recommender System Techniques and Approaches to Improve the Modern Learning Challenges
Authors: S. Aravindha Ramanan
Published: May 2021

Recommendation systems have been developed from the web. These recommendation systems are useful in collecting information from an available set of sources for a user's preferences. The information can be acquired from user's collection of details to share, to review, to do positive ratings by monitoring the user's behavior to improve the quality of top ‘N' recommendations. Now if we come to modern learning system, it has good framework to influence the training factors from the data, triggers, and learner's preferences. Modern learning can be compared to online learning which carries to the future needs. Modern learning can be instituted in schools, engineering colleges, and working campus. The modern learning system combines interrelated data, processes, and resources to create a system of interdependencies that work together, adapting to changing business needs. These interdependencies include multi-level dynamics driven by the organization, training professionals, technological advances, and the learners themselves.
Pedagogical Ontology Modelling for Cell Biology Domain With an Algorithm for Question Generation
Authors: Deepak Gerard , Kumar Ayush , A. Santhanavijayan , C. N. Pushpa , J. Thriveni , K. R. Venugopal
Published: May 2021

In this chapter, an ontology that structures all the cell organelles and their parts are modelled to cognitively model domain knowledge by explicitly establishing relationships among them. The ontologies are modelled depicting the cell as a system and the parts of the cell as the subclasses of the cell along with various functionalities and behavior. The model further focuses on education pedagogy to generate questions based on the modelled ontologies. Furthermore, the defined ontologies are made consistent by defining the classes and the relationship between them, initializing the instances and axiomatizing the developed ontological content. The modelled ontologies are semiotically evaluated using various learners and domain experts. An overall reuse ratio of 0.91 has been achieved, and the proposed ontology has been differentiated from the existing cell ontologies by focusing on an educational pedagogy. Ultimately, an ontology-focused algorithm for multiple choice question generation has been proposed for cell biology as a domain of choice with an accuracy of 90.03%.
Transforming the Productivity of People in the Built Environment
Authors: Underwood Jason , Shelbourn Mark , Carlton Debbie , Zhao Gang , Simpson Martin , Aksenova Gulnaz , Mollasalehi Sajedeh
Published: May 2021

This chapter explores how we create and support a digitally enabled, agile, competent, and ultimately, productive workforce and determines the key research questions that need to be addressed if Digital Built Britain (DBB) is to provide return on investment and succeed as the catalyst for evolving the manner in which we conceive, plan, design, construct, operate, and interact with the built environment. The proposed vision is a digital competency management ecosystem where interdependent stakeholders are incentivised to work together in coopetition to create, capture, infer, interpret, specify, integrate, accredit, apply, use, monitor, and evolve competence as a working (data) asset. This needs to be in a consistent, objective, explicit, and scalable manner, with end2end transparency and traceability for all stakeholders that overcome the challenges of competency management. Moreover, a core element must be an ecosystem organised around digital infrastructure of competency frameworks and other knowledge sources of competence, so that competency frameworks are in digital operation and dynamic context.
The Impact of Macroeconomic Factors on the Hotel Industry Through the Financial Leverage Trends
Authors: Lima Santos Luís , Gomes Conceição , Lisboa Inês
Published: May 2021

In Portugal, news shows that the impact of COVID-19 in the hospitality sector was more noticeable compared to other sectors. This chapter aims to understand the historical trends of hotel industry financial leverage and to analyse the impact of macroeconomic factors on it. Based on the Portuguese reality, it aims to propose a model to be used by managers and shareholders to control the effect of financial leverage over their companies. Two issues are supporting this study: one is if companies evaluate the impact of the chosen financing sources on shareholders' return; another is to understand whether there is a change in the financial leverage effect, either due to macroeconomic factors or due to cyclical factors not controlled by the market, such as the current pandemic (COVID-19) which demands new challenges to companies. Results highlight that the perception of financial leverage by hotel managers is crucial in crisis situations, as the current case of the pandemic caused by COVID-19.
Internet of Things-Based Water Quality Control and Monitoring System for Urban Society
Authors: Sharma Prerna , Jain Piyush , Kharb Latika
Published: May 2021

In this chapter, an attempt has been made to develop a hardware-based remote water quality monitoring system using a single-chip microcontroller, Atmega328P, in synchrony with some sensor technology and GSM/GPRS module for long-distance data transmission. The proposed system is able to perform a qualitative test on the water, taking into consideration both the chemical behavior as well as physical properties exhibited by the latter. The fluid will be analyzed in terms of its ph value (i.e., the molar concentration of hydrogen ions, the haziness caused by the major suspension of minute particles). The device aims to transmit all the deliberated parameters of the wastewater along with the longitude and latitude information to the concerned authorities for real-time monitoring of that data. The subject aims to devise a robust solution that can be used to analyze the quality of large water bodies and send the analysis report to the authorities of pollution control for further implication.
Blockchain of Internet of Things-Based Earthquake Alarming System in Smart Cities
Authors: Kaswan Kuldeep Singh , Dhatterwal Jagjit Singh , Kumar Krishan
Published: May 2021

The worst natural catastrophes occurring in well-settled intelligent cities are earthquakes. A framework of earthquake warning minimizes destruction and protects countless lives. A system built on IoT to identify the earthquake in the S waves and then to warn people by showing them an alert and where the earthquake happened is proposed. An early warning system is generated by a seismic wave survey. The larger the earthquake, the heavier the tremor. The waves are also breaking down the driveway. So the earthquake in the S wave is safer to find. Therefore, determining the extent of the early warning system is essential for creating an earthquake. The chapter addresses the detection of the frequency of earthquakes by identifying the size of earthquakes. In this chapter, we will discuss the elevated processors and IoT (internet of things) that can efficiently deploy an early warning device that can capture and transmit data over networks without manual interference. The early earthquake warning system (EEW) can be used to support smart urban planning, making earthquake areas less sensitive to disasters.