bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Characterization, and In vitro Evaluation of Short Cationic Peptides
for Gene Delivery Vehicle Candidate
Authors: Hidayat Ace Tatang , Maharani Rani , Chaerunisaa Anis Yohana , Masduki Fifi Fitriyah , Aditama Reza , Setiawan Heri , Tarwadi Tarwadi
Published: June 2023

Background:

Amongst gene delivery vehicles, peptide-based vectors have drawn the
intensive attraction of experts globally due to their simplicity and many advantages due to ease in
design, biocompatibility, and safety. Rationally designed peptides are capable of condensing DNA
molecules efficiently and facilitating gene expression in the target cells.

Objective:

This study aims to design, synthesize and evaluate short cationic peptides composed of
several positively charges amino acids of lysine (K) and arginine (R) for gene delivery vehicle candidates.

Methods:

The short cationic peptides of PKKKRKV (P1), CHSPKKKRKV (P2), and YGRKKRRQRRR
(P3) were synthesized using a solid-phase method on 2-chlorotrityl chloride resin.
The crude peptides were purified using RP-HPLC and characterized by HR-TOF-ESI-MS and
1H-NMR. The capability of the peptides to condense DNA was evaluated by ethidium bromide
exclusion assay. Cytotoxicity study of the peptides was carried out in HEK-293T, CHO-K1, and
HepG2 cells using MTT assay. Gene expression facilitated by the peptides was determined in the
HEK-293T.

Results:

The peptides were successfully synthesized with high purity (> 90%) and in a high consistency
with the synthetic products, as shown by the spectroscopic data. Physicochemical and biological
evaluation showed that the cationic peptides are capable of condensing DNA molecule and
have low cytotoxicity to the cells of HEK-293T, CHO-K1, and HepG2. Moreover, the cationic peptides
facilitated gene delivery of green fluorescence protein more efficiently compared to PLL.

Conclusion:

The short cationic peptides rich in lysine and arginine have been successfully synthesized
using solid-phase peptide synthesis method. They were found to be capable of condensing
DNA, have low cytotoxicity, and facilitate gene delivery. However, structure modification or formulation
of cationic peptide with lipid components to form cationic liposome is still needed to enhance
transgene expression by these peptides.
Brain-Derived Neurotrophic Factor – The Protective Agent Against Neurological Disorders
Authors: Koyya Prathyusha , Manthari Ram Kumar , Pandrangi Santhi Latha
Published: June 2023

The burden of neurological illnesses on global health is significant. Our perception of the
molecular and biological mechanisms underlying intellectual processing and behavior has significantly
advanced over the last few decades, laying the groundwork for potential therapies for various neurodegenerative
diseases. A growing body of literature reveals that most neurodegenerative diseases
could be due to the gradual failure of neurons in the brain's neocortex, hippocampus, and various subcortical
areas. Research on various experimental models has uncovered several gene components to
understand the pathogenesis of neurodegenerative disorders. One among them is the brain-derived
neurotrophic factor (BDNF), which performs several vital functions, enhancing synaptic plasticity and
assisting in the emergence of long-term thoughts. The pathophysiology of some neurodegenerative
diseases, including Alzheimer’s, Parkinson’s, Schizophrenia, and Huntington’s, has been linked to
BDNF. According to numerous research, high levels of BDNF are connected to a lower risk of developing
a neurodegenerative disease. As a result, we want to concentrate on BDNF in this article and
outline its protective role against neurological disorders.
Supercritical Fluid Extraction of Phenolics from Anisophyllea disticha (Jack) Baill. and Evaluation of their Antioxidant Activities
Authors: Ferdosh Sahena , Abdul Bari Nurul Ashikin , Wu Bulan , Sarker Md. Zaidul Islam
Published: June 2023

Background:

Anisophyllea disticha (Jack) Baill. (A. disticha) is a species of the Anisophylleaceae family that has undergone the least investigation despite being widely used in folk medicine to cure a wide range of illnesses.

Objective:

The purpose of this study is to examine the impact of various factors on the supercritical fluid extraction of A. disticha in order to maximise recovery of total phenolic content, antioxidant activity, and polyphenol identification.

Method:

The total phenolic content (TPC) and antioxidant activities of A. disticha were determined using the supercritical fluid extraction (SFE) method and compared with Soxhlet. Box-Behnken design of response surface methodology was performed to examine the effect of independent variables of SFE such as temperature, pressure, and concentration of ethanol as co-solvent on TPC and antioxidant activities of A. disticha stem extracts.

Result:

At combined effects of different temperatures, pressure, and co-solvent, the total SFE yield were ranged between 0.65 and 4.14%, which was about half of the Soxhlet extract of 8.75±1.54%. The highest concentration (µg/g) of gallic acid (118.83±1.17), p-coumaric (61.60±0.33), ferulic acid (57.93±1.15), and quercetin (24.16±0.41) were obtained at a temperature of 50 ˚C, the pressure of 25 MPa and co-solvent of 20%, while lowest concentration was found 70 ˚C, 30 MPa, and 20% ethanol.

Conclusion:

SFE extracts possessed remarkable TPC and concentration of phenolic compounds, indicating superior recovery of compounds. SFE showed more than two-fold higher ferric-reducing antioxidant power compared to Soxhlet with values of 585.32±17.01 mg Fe (II)/g extract and 203.63±16.03 mg Fe (II)/g extract, respectively. SFE demonstrated a potential alternative to the classical solvent extraction methods.
A Mini-Review on the Structural Characteristics and Anticancer Activity
of Nagilactones
Authors: Xiao Yuchen , Yong Jianping , Lu Canzhong
Published: June 2023

Natural products provide abundant resources for the development of new drugs. Podocarpus
nagi is an arbor of Podocarpus L'Hér. ex Persoon. Its fruits, leaves, and roots exhibit a
broad spectrum of pharmacological activities (such as antitumor, plant growth regulation, termite
killing, and insect larval toxicity), which have been used in Yao folk for a long history. Nagilactone
is one of the key components discovered in Podocarpus nagi, which has a variety of structures and
a broad spectrum of antitumor activities. In this mini-review, the structures and spectral characteristics,
together with the antitumor activities and the structure-activity relationships of nagilactones,
are summarized by searching the database in order to provide detailed references for researchers to
elucidate and modify their structures.
A Comprehensive Review on Chemistry and Contribution of Chinese
Herb Epimedium brevicornum Maxim in Medicine
Authors: Agrawal Neetu , Goyal Deepika , Bansal Dimple
Published: June 2023

Background:

Traditional Chinese medicine (TCM) is a complete medical system that has been used for more than 2,000 years and it is effective to use Epimedium Brevicornum (EB) Maxim, one of the Chinese herbs belonging to the family Berberidaceae is of major use because of its bioactive compound Icariin (ICA).

Objective:

This review aims on providing a collective report of the description, taxonomy, therapeutic uses, bioactive compounds, and the different pharmacological activities of the plant EB for future research.

Methods:

Data was obtained from various informative tools like PubMed, ScienceDirect, Google Scholar, and the botanical information sites for different plants.

Results:

This literature review shows that the Chinese herb EB possesses various therapeutic effects and can be used in the prophylaxis of different ailments. The extract of different parts of EB contains many bioactive compounds such as phenols, flavonoids, and lignans. They show a wide range of pharmacological activities which include anti-inflammatory, anti-infertility, anti-cancer, and effective against Alzheimer’s disease and osteoporosis. ICA was found to be the major constituent of this herbal plant aiding in almost every pharmacological activity
.

Conclusion:

The review covers every activity the plant holds and indicates that the plant is a useful source in eradicating a variety of ailments. Researchers have performed invitro and invivo experiments to explore plant capabilities. The plant could be of very much use in botanical and pharmacological fields. For experts aiming to research EB, this review could be a great source of information.
A Critical Review of Gain Enhancement Methods for Microstrip Antenna
Authors: Quzwain Kamelia , Nabila Haifa , Anwar Radial , Ismail Alyani
Published: June 2023

In the recent years, the development in communication system has grown rapidly, especially
for the growth of broadband wireless technologies. This technology has some advantages, for
instance, flexibility for the transmission of data with very high data rate communications. Antenna
is one of the crucial components of broadband wireless systems because it has ability to emit and
receive radio waves. There are various types of antennas and microstrip is one of the most popular
designs nowadays. This antenna has some advantages and disadvantages. Low gain is known as one
of the disadvantages of microstrip antenna. However, there are numerous methods which can be
used to enhance gain. Some researches have been done by numerous researchers throughout the
world in tackling this disadvantage. This paper presents a critical review of different methods employed
to alleviate this problem. For ease of understanding, this paper is classified into five approaches:
array configuration approaches, air substrate approaches, metamaterial approaches, yagiuda
approaches, and other approaches.
Promoting civic engagement among students in the preservation of local culture during a time of disruption
Authors: Indriyani Dina , Komalasari Kokom , Malihah Elly , Fitriasari Susan
Published: June 2023

Citizenship education aims to cultivate intelligent and responsible citizens. One essential characteristic of a responsible citizen is their active engagement in civic duties, as demonstrated through their attitudes and behavior. This study examines the level of civic engagement among high school students in preserving local culture during the era of disruption. The research adopts a quantitative descriptive approach and collects data from high school students in Cianjur Regency, Indonesia, using a survey questionnaire. The findings reveal that: (1) the level of civic attitude among students in cultural preservation is sufficient, with a score of 55.12%; and (2) the level of civic behavior, specifically real action taken to preserve local culture, is very low, with a score of 9.22%. This suggests that student involvement in cultural preservation needs to be further developed to safeguard local culture. Therefore, future researchers are advised to devise a Citizenship education learning model that can foster civic engagement among high school students in preserving local culture.
Experimental test analysis of hydram pump flow rate using L9 Taguchi at fish pond aquaculture
Authors: Prihatin Joko Yunianto , Pangestu Brillian Adjie , Kristiyono Roedy , Sulistyadi Sulistyadi
Published: June 2023

Good water quality in fish nursery cultivation greatly influences the harvest quality. Temperature and Ph can be maintained properly with proper air circulation. The main problem is that the best flow rate quality in fish ponds of 0.123m3/second is only achieved through the flow from the dam. In this study, the installation of hydram pumps in fish ponds was carried out with the angle of assessing the inflow and discharge to adjust to variations in the diameter of the inlet and outlet pipes, the height of the inlet pipe, and the height of the tank. The experimental design used L9 orthogonal array Taguchi with four replicas. The result of this study was that the maximum value of the input flow rate was 305.73 cm3/second, and the discharge flow rate was 40.35 cm3/second. The maximum value was in the 8th composition; namely, the variation of the inlet pipe height was 200 in, the outlet pipe height was 350 cm, the inlet pipe diameter was 1 in, and the outlet pipe diameter was ½ in.
Algoritme Migrating Birds Optimization dan Algoritme Particle Swarm Optimization: Penyelesaian Masalah Knapsack 0-1
Authors: Silalahi Bib Paruhum , Novanto Mohamad , Supriyo Prapto Tri
Published: June 2023

Permasalahan knapsack merupakan salah satu masalah optimisasi. Masalah knapsack merupakan suatu permasalahan bagaimana memilih objek dari beberapa objek yang akan dimasukkan ke media penyimpanan dengan masing-masing objek memiliki bobot dan total bobot dari objek yang dipilih tidak boleh melebihi kapasitas media penyimpanannya, sehingga diperoleh nilai yang  maksimal. Ketika objek yang dimasukkan ke dalam media penyimpanan bersifat harus dimasukkan semua atau tidak sama sekali, permasalahan ini dikenal dengan nama knapsack 0-1.  Salah satu metode penyelesaian masalah knapsack 0-1 adalah dengan menggunakan metode meta-heuristic.  Terdapat beberapa metode meta-heuristic seperti algoritma migrating birds optimization dan particle swarm optimization.  Paper ini membahas bagaimana algoritma migrating birds optimization dan particle swarm optimization digunakan dalam menyelesaikan permasalahan knapsack 0-1.  Kemudian dilakukan perbandingan kinerja kedua algoritma tersebut berdasarkan  nilai fungsi tujuan untuk beberapa studi kasus. Berdasarkan hasil penelitian ini algoritme migrating birds optimization mempunyai nilai hasil fungsi objektif yang lebih baik dibandingkan dengan algoritma particle swarm optimization.Migrating Birds Optimization Algorithm and Particle Swarm Optimization Algorithm: Knapsack problem solving 0-1AbstractThe knapsack problem is one of the optimization problems. The knapsack problem is a problem of how to select objects from several objects to be inserted into the storage with each object having a weight and the total weight of the selected object must not exceed the capacity of the storage so that the maximum value is obtained. When objects that are inserted into the storage have the character of having to be included all or nothing, this problem is known as the 0-1 knapsack. One of the methods of solving the 0-1 knapsack problem is by using the meta-heuristic method. There are several meta-heuristic methods such as the migrating birds optimization algorithm and particle swarm optimization. This paper discusses how migrating birds optimization and particle swarm optimization algorithms are used to solve the 0-1 knapsack problem. Then the performance of the two algorithms is compared based on the objective function values for several case studies. Based on the results of this study, the migrating birds optimization algorithm has better objective function values than the particle swarm optimization algorithm.
Tinjauan Matematis Waktu Tundaan pada Model Covid-19 dengan Vaksinansi
Authors: Saptaningtyas Fitriana Yuli , Ahmadi Ahmadi
Published: June 2023

Artikel ini membahas pemodelan matematika penyebaran Covid-19 dengan vaksinasi yang melibatkan waktu tundaan. Waktu tundaan merepresentasikan waktu individu mengalami penurunan kekebalan tubuh sehingga kembali rentan terhadap Covid-19 setelah sembuh. Kita tahu bahwa individu yang dinyatakan sembuh dari Covid-19 dapat terinfeksi kembali. Penelitian ini menganalisa titik ekuilibirum beserta kestabilannya, menentukan bilangan reproduksi dasar untuk melihat penyebaran penyakit, menentukan jenis bifurkasi yang muncul yang diakibatkan oleh waktu tundaan, dan melakukan simulasi numerik untuk melihat perilaku penyebaran penyakit. Di samping itu juga dilakukan kajian analitik untuk menentukan bilangan reproduksi dasar dan analisa perbandingan kestabilan lokal untuk model tanpa waktu tundaan dan dengan waktu tundaan. Hasil dari analisis terhadap model didapat dua titik ekuilibrium, yakni satu bebas penyakit dan satu endemik. Pada model dengan waktu tundaan diperoleh bahwa waktu tundaan tertentu  dapat menyebabkan munculnya solusi periodik artinya akan terjadi fluktuasi banyaknya individu yang terinveksi pada periode waktu tertentu. Simulasi numerik dengan mengubah ubah parameter waktu tundaan dan tingkat vaksinasi menunjukkan pada kondisi endemik model dengan waktu tundaan akan menyebabkan lebih banyak individu yang terinveksi dari pada model tanpa waktu tundaan. Mathematical Overview of Time Delay on Covid 19 Models with VaccinationAbstractThis article discusses the mathematical modeling of the spread of Covid-19 with vaccination which involves a time delay. The time delay is represented when an individual experiences a decreased immune system so that he is declared susceptible to Covid-19 after recovering. Because we know that individuals who are declared cured of Covid-19 can be reinfected, this study analyzes the equilibrium point of the model and its stability, determines the primary reproduction number to see the spread of the disease, determines the type of bifurcation that appears due to the time delay, and performs numerical simulations. To see the behavior of the spread of the disease. In addition, analytical studies were carried out to determine the primary reproduction number and local stability comparison analysis for models without time delay and with time delay. The model analysis results obtained two equilibrium points, one free of disease and one endemic. In the time-delayed model, the value of the time-delay parameter is obtained, which causes the emergence of a periodic solution, meaning that there will be fluctuations in the number of individuals infected in a certain period. Numerical simulations by changing the time delay parameters and vaccination rates show that in endemic conditions, models with time delays will cause more individuals to be infected than models that do not use time delays.
Anisotropy of the Paramagnetic Susceptibility in the 3D Dirac Semimetal Cd-=SUB=-3-=/SUB=-As-=SUB=-2-=/SUB=- Caused by Chromium Impurity: the EPR on Cr-=SUP=-3+-=/SUP=- Ions
Authors: Goryunov Yu. V.  , Nateprov A. N.
Published: June 2023

In the literature devoted to magnetic impurities in Dirac semimetals, the appearance of anisotropic and long-range non-oscillating contributions to the Ruderman--Kittel--Kasuya--Yosida interaction is predicted. These contributions are due to the hybridization of the wave functions of magnetic impurities with the wave functions of Dirac electrons, which have a linear dispersion law. We have studied electron paramagnetic resonance (EPR) in powder samples of topological 3D Dirac semimetal Cd3As2 with an admixture of chromium ions. Anisotropy of the magnetic susceptibility in the paramagnetic state was found from the behavior of the resonance field. The appearance of magnetic anisotropy in the paramagnetic state is associated with an increase in the contribution of the orbital moments of chromium ions Cr2+ and Cr3+ due to their interaction with the orbital moments of donor Dirac electrons, which have anomalously large values of g factors. Keywords: magnetic resonance, topological materials, magnetic impurities.
Pasta Fortification with Leaves of Edible Wild Plants to Lower the P Glycaemic Index of Handmade Fresh Noodles
Authors: Ombra Maria Neve , Nazzaro Filomena , Fratianni Florinda
Published: June 2023

Edible wild plants are a largely available food at no cost and an emblem of sustainability. Among the numerous varieties of edible wild plants, purslane (Portulaca oleracea L.) and common mallow (Malva sylvestris L.) are good sources of healthful bioactive compounds. Therefore, there is a growing interest in their consumption for health-related nutritional and sustainable perspectives. Fresh durum wheat tagliatelle fortified with dried and pulverized leaves of mallow or purslane at two distinct percentages of integration (3%, 6%) were handmade. Polyphenols, pigments, and carotenoids were extracted and quantified. The in vitro inhibitory effect against digestive enzymes and the predicted glycaemic response were assessed. All samples exhibited appreciable quantities of polyphenols, pigments, and enzymatic inhibition of α-amylase and α glucosidase in vitro. The estimated glycaemic index for pasta fortified with 3% or 6% purslane powder was reduced by 10.8% or 28.3%, respectively, compared to pasta with durum wheat semolina alone. For mallow-enriched pasta at 3 and 6%, the reductions were 24.3% and 21.6%, in the order. The lowest expected glycaemic index was obtained with pasta 6% purslane powder enriched (P6c = 53 +/- 2.2). In this study, mallow and purslane were tested to be used as natural sources for producing handmade enriched pasta. All the fortified samples presented a lower pGI concerning control pasta, thus indicating that plant powder addition could be suitably adopted. Their valuable and functional compounds reduced the pGI and imparted a pleasant natural color to the pasta.
Mutations of SARS-CoV-2 Structural Proteins in the Alpha, Beta, Gamma, and Delta Variants: Bioinformatics Analysis
Authors: Khetran Saima Rehman , Mustafa Roma
Published: June 2023

Background

COVID-19 and Middle East Respiratory Syndrome are two pandemic respiratory diseases caused by coronavirus species. The novel disease COVID-19 caused by SARS-CoV-2 was first reported in Wuhan, Hubei Province, China, in December 2019, and became a pandemic within 2-3 months, affecting social and economic platforms worldwide. Despite the rapid development of vaccines, there have been obstacles to their distribution, including a lack of fundamental resources, poor immunization, and manual vaccine replication. Several variants of the original Wuhan strain have emerged in the last 3 years, which can pose a further challenge for control and vaccine development.

Objective

The aim of this study was to comprehensively analyze mutations in SARS-CoV-2 variants of concern (VoCs) using a bioinformatics approach toward identifying novel mutations that may be helpful in developing new vaccines by targeting these sites.

Methods

Reference sequences of the SARS-CoV-2 spike (YP_009724390) and nucleocapsid (YP_009724397) proteins were compared to retrieved sequences of isolates of four VoCs from 14 countries for mutational and evolutionary analyses. Multiple sequence alignment was performed and phylogenetic trees were constructed by the neighbor-joining method with 1000 bootstrap replicates using MEGA (version 6). Mutations in amino acid sequences were analyzed using the MultAlin online tool (version 5.4.1).

Results

Among the four VoCs, a total of 143 nonsynonymous mutations and 8 deletions were identified in the spike and nucleocapsid proteins. Multiple sequence alignment and amino acid substitution analysis revealed new mutations, including G72W, M2101I, L139F, 209-211 deletion, G212S, P199L, P67S, I292T, and substitutions with unknown amino acid replacement, reported in Egypt (MW533289), the United Kingdom (MT906649), and other regions. The variants B.1.1.7 (Alpha variant) and B.1.617.2 (Delta variant), characterized by higher transmissibility and lethality, harbored the amino acid substitutions D614G, R203K, and G204R with higher prevalence rates in most sequences. Phylogenetic analysis among the novel SARS-CoV-2 variant proteins and some previously reported β-coronavirus proteins indicated that either the evolutionary clade was weakly supported or not supported at all by the β-coronavirus species.

Conclusions

This study could contribute toward gaining a better understanding of the basic nature of SARS-CoV-2 and its four major variants. The numerous novel mutations detected could also provide a better understanding of VoCs and help in identifying suitable mutations for vaccine targets. Moreover, these data offer evidence for new types of mutations in VoCs, which will provide insight into the epidemiology of SARS-CoV-2.
Methods Used in the Development of Common Data Models for Health Data: Scoping Review
Authors: Ahmadi Najia , Zoch Michele , Kelbert Patricia , Noll Richard , Schaaf Jannik , Wolfien Markus , Sedlmayr Martin
Published: June 2023

Background

Common data models (CDMs) are essential tools for data harmonization, which can lead to significant improvements in the health domain. CDMs unite data from disparate sources and ease collaborations across institutions, resulting in the generation of large standardized data repositories across different entities. An overview of existing CDMs and methods used to develop these data sets may assist in the development process of future models for the health domain, such as for decision support systems.

Objective

This scoping review investigates methods used in the development of CDMs for health data. We aim to provide a broad overview of approaches and guidelines that are used in the development of CDMs (ie, common data elements or common data sets) for different health domains on an international level.

Methods

This scoping review followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. We conducted the literature search in prominent databases, namely, PubMed, Web of Science, Science Direct, and Scopus, starting from January 2000 until March 2022. We identified and screened 1309 articles. The included articles were evaluated based on the type of adopted method, which was used in the conception, users’ needs collection, implementation, and evaluation phases of CDMs, and whether stakeholders (such as medical experts, patients’ representatives, and IT staff) were involved during the process. Moreover, the models were grouped into iterative or linear types based on the imperativeness of the stages during development.

Results

We finally identified 59 articles that fit our eligibility criteria. Of these articles, 45 specifically focused on common medical conditions, 10 focused on rare medical conditions, and the remaining 4 focused on both conditions. The development process usually involved stakeholders but in different ways (eg, working group meetings, Delphi approaches, interviews, and questionnaires). Twenty-two models followed an iterative process.

Conclusions

The included articles showed the diversity of methods used to develop a CDM in different domains of health. We highlight the need for more specialized CDM development methods in the health domain and propose a suggestive development process that might ease the development of CDMs in the health domain in the future.
Designing High-Fidelity Mobile Health for Depression in Indonesian Adolescents Using Design Science Research: Mixed Method Approaches
Authors: Shania Mila , Handayani Putu Wuri , Asih Sali
Published: June 2023

Background

COVID-19 mitigation protocols, enacted to control the pandemic, have also been shown to have a negative impact on mental health, including the mental health of adolescents. The threat of being infected by SARS-CoV-2 and substantial changes in lifestyle, including limited social interaction due to stay-at-home orders, led to loneliness as well as depressive symptoms. However, offline psychological assistance is restricted, as psychologists are bounded by mitigation protocols. Further, not all adolescents’ guardians are open to their children attending or have the means to pay for psychological service; thus, adolescents remain untreated. Having a mobile health (mHealth) app for mental health that uses monitoring, provides social networks, and delivers psychoeducation may provide a solution, especially in countries that have limited health facilities and mental health workers.

Objective

This study aimed to design an mHealth app to help prevent and monitor depression in adolescents. The design of this mHealth app was carried out as a high-fidelity prototype.

Methods

We used a design science research (DSR) methodology with 3 iterations and 8 golden rule guidelines. The first iteration used interviews, and the second and third iterations used mixed method approaches. The DSR stages include the following: (1) identify the problem; (2) define the solution; (3) define the solution objective; (4) develop, demonstrate, and evaluate the solution; and (5) communicate the solution. This study involved students and medical experts.

Results

The first iteration resulted in a wireframe and prototype for the next iteration. The second iteration resulted in a System Usability Scale score of 67.27, indicating a good fit. In the third iteration, the system usefulness, information quality, interface quality, and overall values were 2.416, 2.341, 2.597, and 2.261, respectively, indicating a good design. Key features of this mHealth app include a mood tracker, community, activity target, and meditation, and supporting features that complement the design include education articles and early detection features.

Conclusions

Our findings provide guidance for health facilities and to design and implement future mHealth apps to help treat adolescent depression.
Development of an Evidence-Based Conceptual Model of the Health Care Sector Under Digital Transformation: Integrative Review (Preprint)
Authors: Konopik Jens , Blunck Dominik
Published: June 2023

BACKGROUND

Digital transformation is currently one of the most influential developments. It is fundamentally changing consumers’ expectations and behaviors, challenging traditional firms, and disrupting numerous markets. Recent discussions in the health care sector tend to assess the influence of technological implications but neglect other factors needed for a holistic view on the digital transformation. This calls for a reevaluation of the current state of digital transformation in health care. Consequently, there is a need for a holistic view on the complex interdependencies of digital transformation in the health care sector.

OBJECTIVE

This study aimed to examine the effects of digital transformation on the health care sector. This is accomplished by providing a conceptual model of the health care sector under digital transformation.

METHODS

First, the most essential stakeholders in the health care sector were identified by a scoping review and grounded theory approach. Second, the effects on these stakeholders were assessed. PubMed, Web of Science, and Dimensions were searched for relevant studies. On the basis of an integrative review and grounded theory methodology, the relevant academic literature was systematized and quantitatively and qualitatively analyzed to evaluate the impact on the value creation of, and the relationships among, the stakeholders. Third, the findings were synthesized into a conceptual model of the health care sector under digital transformation.

RESULTS

A total of 2505 records were identified from the database search; of these, 140 (5.59%) were included and analyzed. The results revealed that providers of medical treatments, patients, governing institutions, and payers are the most essential stakeholders in the health care sector. As for the individual stakeholders, patients are experiencing a technology-enabled growth of influence in the sector. Providers are becoming increasingly dependent on intermediaries for essential parts of the value creation and patient interaction. Payers are expected to try to increase their influence on intermediaries to exploit the enormous amounts of data while seeing their business models be challenged by emerging technologies. Governing institutions regulating the health care sector are increasingly facing challenges from new entrants in the sector. Intermediaries increasingly interconnect all these stakeholders, which in turn drives new ways of value creation. These collaborative efforts have led to the establishment of a virtually integrated health care ecosystem.

CONCLUSIONS

The conceptual model provides a novel and evidence-based perspective on the interrelations among actors in the health care sector, indicating that individual stakeholders need to recognize their role in the system. The model can be the basis of further evaluations of strategic actions of actors and their effects on other actors or the health care ecosystem itself.
Design Validation of a Relational Agent by COVID-19 Patients: Mixed Methods Study (Preprint)
Authors: Islam Ashraful , Chaudhry Beenish Moalla
Published: June 2023

BACKGROUND

Relational agents (RAs) have shown effectiveness in various health interventions with and without doctors and hospital facilities. In situations such as a pandemic like the COVID-19 pandemic when health care professionals (HCPs) and facilities are unable to cope with increased demands, RAs may play a major role in ameliorating the situation. However, they have not been well explored in this domain.

OBJECTIVE

This study aimed to design a prototypical RA in collaboration with COVID-19 patients and HCPs and test it with the potential users, for its ability to deliver services during a pandemic.

METHODS

The RA was designed and developed in collaboration with people with COVID-19 (n=21) and 2 groups of HCPs (n=19 and n=16, respectively) to aid COVID-19 patients at various stages by performing 4 main tasks: testing guidance, support during self-isolation, handling emergency situations, and promoting postrecovery mental well-being. A design validation survey was conducted with 98 individuals to evaluate the usability of the prototype using the System Usability Scale (SUS), and the participants provided feedback on the design. In addition, the RA’s usefulness and acceptability were rated by the participants using Likert scales.

RESULTS

In the design validation survey, the prototypical RA received an average SUS score of 58.82. Moreover, 90% (88/98) of participants perceived it to be helpful, and 69% (68/98) of participants accepted it as a viable alternative to HCPs. The prototypical RA received favorable feedback from the participants, and they were inclined to accept it as an alternative to HCPs in non-life-threatening scenarios despite the usability rating falling below the acceptable threshold.

CONCLUSIONS

Based on participants’ feedback, we recommend further development of the RA with improved automation and emotional support, ability to provide information, tracking, and specific recommendations.
Association Between Clinician-Level Factors and Patient Outcomes in Virtual and In-Person Outpatient Treatment for Substance Use Disorders: Multilevel Analysis (Preprint)
Authors: Welsh Justine W , Sitar Siara I , Parks Michael J , Patton Samantha C , Braughton Jacqueline E , Waller Lance A , Ngo Quyen M
Published: June 2023

BACKGROUND

The use of virtual treatment services increased dramatically during the COVID-19 pandemic. Unfortunately, large-scale research on virtual treatment for substance use disorder (SUD), including factors that may influence outcomes, has not advanced with the rapidly changing landscape.

OBJECTIVE

This study aims to evaluate the link between clinician-level factors and patient outcomes in populations receiving virtual and in-person intensive outpatient services.

METHODS

Data came from patients (n=1410) treated in a virtual intensive outpatient program (VIOP) and an in-person intensive outpatient program (IOP), who were discharged between January 2020 and March 2021 from a national treatment organization. Patient data were nested by treatment providers (n=58) examining associations with no-shows and discharge with staff approval. Empathy, comfort with technology, perceived stress, resistance to change, and demographic covariates were examined at the clinician level.

RESULTS

The VIOP (β=–5.71; P=.03) and the personal distress subscale measure (β=–6.31; P=.003) were negatively associated with the percentage of no-shows. The VIOP was positively associated with discharges with staff approval (odds ratio [OR] 2.38, 95% CI 1.50-3.76). Clinician scores on perspective taking (β=–9.22; P=.02), personal distress (β=–9.44; P=.02), and male clinician gender (β=–6.43; P=.04) were negatively associated with in-person no-shows. Patient load was positively associated with discharge with staff approval (OR 1.04, 95% CI 1.02-1.06).

CONCLUSIONS

Overall, patients in the VIOP had fewer no-shows and a higher rate of successful discharge. Few clinician-level characteristics were significantly associated with patient outcomes. Further research is necessary to understand the relationships among factors such as clinician gender, patient load, personal distress, and patient retention.

CLINICALTRIAL
Digitization of Corruption Through Authorization Management -- Why Disinformation Is Harmful to Science and Constitutes Violence (Preprint)
Authors: Pachankis Yang
Published: June 2023

UNSTRUCTURED

When one value system is used to interpret the happenings of another value system, there is a problem of definition. The research delves into the scientific basis of disinformation. With the intention to deceive, and the damages to human security, the research defines disinformation as terrorist behaviors and violence, and adopts the wording corruption from a value-orientated structure in description of a structurally designed crime. With the fundamentalism of the Universal Declaration of Human Rights and the right to health, the research delves into the dual-track price system in mainland China and its implications to medical resource inequality in the regional setting, and its potential impacts on the global public health institutions. It is demonstrated that disinformation can provide near-perfect advantage in a negative sum game, and render all security systems can remain as von Neumann ordinals. Furthermore, medical resource inequality in the People's Republic of China (PRC) is the result from the structural power design, with the military strategy's modern manifestations with the dual-track price system underlying its "Reform and Opening". With the consistent behavioral patterns from the power advantage perspective, authorization system construction in public health management digital systems has further increased the efficacy and cost-efficiency for the sustainable proliferation of the illicit corruption reach. The research adopts a behavioral science perspective to the problems of public health equity in PRC exemplified by the COVID-19 pandemic, and the military intentions behind disinformation on security systems are evidenced. The evidence implies that terrorism activities do not necessarily have to involve direct attacks nor physical violence.
CROSS-SECTIONAL SURVEY TO ASSESS THE BENEFICIARIES EXPERIENCE REGARDING COVID-19 VACCINATION IN VACCINATED CANDIDATES IN A TRIBAL DISTRICT OF RAJASTHAN - EMIGH PROSPECTIVE
Authors: Bhujade Rashmi , Yadav Kanak , Kumar Jignesh , Pukar Mahesh , Bhatt Ravi , Baghel Anil Singh , Ray ShashiKANT , Kumar Rakesh
Published: June 2023

Objectives: A year with COVID-19 has been a harrowing breakneck journey. On 11th March 2020, the World Health Organization declared COVID-19 as a pandemic. It spread across globe in span of 3 months; this is how emergence of unknown virus became a multifaceted pandemic. Till date, no definitive treatment of covid-19 is available, except hope of vaccination. We must ensure safe and effective vaccination to protect people. It has been largest vaccination drive, that’s why important to know the beneficiary’s point of view regarding covid vaccination process, so that the result of this study can be used to amend the process if needed, to make the process more beneficiary friendly.
Methods: A cross-sectional study was conducted in a government covid vaccination centerto assess the beneficiaries prospective about their experience of covid-19 vaccine. The study duration was 6 months. Data were collected with the help of semi-structured pro forma.
Results: Data analysis was done with the help of SPSS-20. Approximately 93% of participants received vaccination appointment. Around 58% of participants were screened for COVID-19 symptoms. Most (90%) participants said that physical distancing was maintained during vaccination, 93% participants were informed about of vaccination process, 85% participants mentioned that staff had explained about adverse event following immunization (AEFI) before vaccination, and 76% of participants mentioned that they received Covishied, only 1 participant reported AEFI within 30 min of waiting period, and he received the preliminary treatment at vaccination center.
Conclusion: Feedback from the user is a good way to quality check; their reviews give the opportunity to improve. Most of the vaccines were satisfied with the vaccination procedure.
СЕТИ 5G: ЭВОЛЮЦИЯ К ОТКРЫТОЙ СЕТЕВОЙ АРХИТЕКТУРЕ. ЧАСТЬ 2. СТАНДАРТИЗАЦИЯ РЕШЕНИЙ ДЛЯ ОТКРЫТОЙ СЕТЕВОЙ ИНФРАСТРУКТУРЫ И РАДИОДОСТУПА 5G
Authors: Коган С.С.
Published: June 2023

При развертывании сетей мобильной связи 5G поверх существующей или вновь создаваемой сетевой инфраструктуры операторы и провайдеры телекоммуникационных услуг заинтересованы во внедрении открытых решений, позволяющих использовать на одной сети аппаратные платформы и программное обеспечение разных производителей. Этот интерес стимулируется также внедрением на сети 5G новых, облачных, технологий с широким использованием центров хранения и обработки данных. В цикле статей даны определения основных элементов (часть 1) и представлен обзор работ по стандартизации (часть 2) открытых решений и интерфейсов для сетевой инфраструктуры 5G.
Effects of e-Health Literacy and Aging Attitude on Health Promotion Behavior in Middle-aged Adults
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Mun Mi Yeong , Kang Seok-Jung
Published: June 2023

Objectives This study is to identify the degree of e-health literacy, aging attitude, and health promotion behavior in middle-aged adults, and to confirm the effect of e-health literacy and aging attitude on health promotion behavior. Methods Data were collected from October 20 to October 28, 2021 using a structured questionnaire targeting 111 middle-aged adults aged 40 to under 65 in one region. The collected data were analyzed by descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and multiple linear regression analysis using the SPSS/WIN 26.0 statistical program. Results e-health literacy had a statistically significant positive correlation with aging attitude (r=.44, p<.001) and health promotion behavior (r=.47, p<.001). Aging attitude also had a statistically significant positive correlation with health promotion behavior (r=.54, p<.001). As a result of multiple regression analysis, the factors significantly affecting health promotion behavior were aging attitude (β=.38, p<.001), exercise for more than 30 minutes (β= .32, p<.001), and e-health literacy (β=.29, p<.001) had a high influence on health promotion behavior. The overall explanatory power of these variables was 44.0%. Conclusions Development of various programs, institutional support, and policy preparation are required to improve middle-aged adults’ e-health literacy and maintain a positive and mature aging attitude.
Introduction and Tasks of medical Support Policy for Students with Severe and Multiple Disabilities: Focusing on Finished and Unfinished Tasks
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Baek Sujin , An Sangkwon , Lim Yongjae
Published: June 2023

Objectives The medical support policy for students with severe and multiple disabilities (SSMD) was adopted as one of the 2017 National Base Plans. The purposes of the present study was to clarify the contents of medical support policy for SSMD, and to derive future tasks to be solved by the nation, the office of education, and school. Methods The analysis data were 42 official documents published between 2017 and 2022. The 42 documents were analyzed by content analysis. Each content was classified into ‘planning’, ‘preparation’, ‘implementation’, and ‘evaluation’ stages, and divided into the finished and unfinished tasks. The future tasks were selected from the finished and unfinished tasks. Results First, the 42 documents of medical support policy for SSMD were classified into four stages. The planning was the most common with 19 cases (45.2%), and followed by preparation with 13 cases (31.0%), implementation with 7 cases (16.7%), and evaluation with 3 cases (7.1%). Second, after analyzing the finished and unfinished tasks, the 4 future tasks were selected: (a) Law revision, (b) Policy support and institutional improvement, (c) Collaboration of related departments, (d) Budget expansion. Conclusions In order to provide more stable and systematic medical support to SSMD, it is necessary to focus on law revision based on experimental operation for medical support at the school level, promotion of policy support and system improvement at the national levels, promotion of disability understanding, collaboration of related departments, and expansion of qualitative research.
The Effects of Writing Using Reflection Questions on Counseling Performance of Novice Counselors
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Su Ho , Jang Yoojin
Published: June 2023

Objectives This study was conducted to examine the effects of reflective writing using reflection questions on the counseling performance of novice counselors. Methods The study involved conducting writing activities three times for a group of seven novice counselors with less than three years of counseling experience. Participants were selected through convenience sampling, and interviews were conducted based on their writing experiences. The interview data were analyzed using the content analysis method suggested by Kripendorff (2003). Two dimensions, ‘reflection dimension’ and ‘change dimension’, were identified and ‘comparison dimension’ was added due to the nature of the study to compare supervision and writing experiences, which yielded three dimensions, eight categories, and 31 meanings. Results The participants experienced introspection on their internal factors or the counseling process, reflection on counseling performance, and changes related to self-perception as counselor and counseling performance. They were also able to challenge themselves with new approaches. In comparison to counseling supervision, they reported that reflective writing were helpful in accepting their own difficulties, focusing on themselves, and looking back on the counseling process in detail. However, some participants found it difficult to consider the difficulties of the client from different perspectives, or felt the need for supervision for specific techniques or interventions for change. Conclusions The study confirmed the possibility of using reflective writing in education and training programs to assist novice counselors in performing counseling.