bluuebunny/crossref_metadata_2025 huggingface dataset:
Metodologias ativas para a aprendizagem na Instituição de Ensino Superior
Authors: Carvalho Rozana Neves Guimarães de , Demberg Rafaela Rodrigues , Ferraz Rodrigo Meireles , Santos Isabelle Pereira dos , Pereira Evelyn da Silva , Silva Jessica Rodrigues , Pereira Douglas dos Santos Vermil , Silva Jorge Luiz Lima da , Poeys Jéssica Moreira , Barreto Isabella Lima Rohan
Published: September 2022

O presente estudo tem por escopo tematizar a respeito das metodologias ativas na Instituição de Ensino Superior. Portanto, tem por finalidade trazer uma breve contextualização sobre a história da educação, conhecer os conceitos, papel do docente e os fundamentos das metodologias ativas, de modo a compreender os impactos positivos e negativos para o processo de ensino- aprendizagem dos estudantes universitários. Adicionalmente, apontar as metodologias ativas enquanto medidas estratégicas durante o contexto pandêmico, no qual as aulas migraram da modalidade presencial para o ambiente remoto. Metodologicamente, pauta-se, na pesquisa bibliográfica, através da seleção de artigos para responder os assuntos referidos anteriormente. Dessa forma, os artigos foram analisados, selecionados e discutidos a partir de categorias temáticas. O artigo está delineado em seções, estando a segunda seção dividida em quatro subseções, a saber: 1) apresenta um breve histórico sobre a educação; 2.0) aborda o conceito de metodologias ativas, seguindo: 2.1) o papel do professor; 2.2) vantagens e impactos para os estudantes universitários; 2.3) desafios para a implementação e 2.4) influência da Pandemia de COVID-19. Conclui-se que as metodologias ativas proporcionam ao corpo docente recursos para estimular ações reflexivas nos universitários, formando indivíduos livres, dotados de autonomia e capazes de lidar com problemas, dessa forma, tornam-se aptos para construírem seus próprios caminhos. A pesquisa colaborou não só na amplificação sobre o conhecimento do assunto, mas também para incentivar os docentes a considerá-las e inseri-las, gradualmente, nas suas práticas educacionais.
Avaliação das características agronômicas de três acessos de morangueiro no sul de Minas Gerais - Brasil
Authors: Ribeiro Natali , Antunes Luiz Fernando de Sousa , Barros Adamastor Pereira , Santos Carlos Antonio dos , Carmo Margarida Goréte Ferreira do
Published: September 2022

Dentre as pequenas frutas, o morango é o pseudofruto mais comercializado no mundo. A cada ano, o Brasil vem aumentando sua produção, porém é dependente de cultivares desenvolvidas por programas de melhoramento estrangeiras. O objetivo deste trabalho foi avaliar três acessos de morangueiro desenvolvidos por produtor rural, nas condições edafoclimáticas do sul de Minas Gerais, analisando seu potencial agronômico. Foram avaliados produção precoce e total, número de frutos, diâmetro (mm), comprimento (mm), peso (g), teor de sólidos solúveis totais (°Brix). Conclui-se que o potencial agronômico dos acessos NP9 e NP15 são equivalentes e em algumas características superiores a cultivar ‘Oso Grande’, podendo ser recomendada para plantio nas condições do sul de Minas Gerais, após seu registro junto ao MAPA, reduzindo a dependência de cultivares de origem estrangeira e suas implicações.
Manifestações orais e maxilofaciais da Doença Celíaca
Authors: Afonso Áquila de Oliveira , Carneiro Kaio Henrique da Silva , Santos Francine Militão dos , Rocha Paulo Victor Gomes da , Araújo Felipe Rafael da Cunha , Silva Lucas Pinheiro da , Rico Camila Melo , Silva Gabriela Santos , Melazzo Giulliana Gonçalves Fonseca , Gonçalves Júnior Heuber de Sales
Published: September 2022

A doença celíaca (DC) é uma doença autoimune que afeta tanto o epitélio quanto a lâmina própria do intestino delgado em indivíduos geneticamente suscetíveis e intoleráveis ​​ao glúten. A sensibilidade ao glúten causa atrofia das vilosidades, que se resolve com uma dieta sem glúten. Quando não diagnosticada precocemente, a DC pode acarretar impacto significativo na qualidade de vida, principalmente relacionado aos sintomas clínicos como síndrome do intestino irritável e transtornos psiquiátricos. Nesse sentindo, este artigo visa revisar a literatura acerca das manifestações orais e maxilofaciais decorrentes da Doença Celíaca. Para a construção deste artigo foi feito um levantamento bibliográfico nas bases de dados SciVerse Scopus, Scientific Eletronic Library Online (Scielo), U.S. National Library of Medicine (PUBMED) e ScienceDirect, usando o gerenciador de referências Mendeley. Os artigos foram coletados no período de fevereiro a julho de 2022 e contemplados entre os anos de 2015 a 2022.As principais manifestações orais e complicações relacionadas ao quadro de doença celíaca incluem hipoplasia do esmalte, ulcerações aftosas recorrentes, cárie dentária, glossite atrófica e líquen plano. As manifestações orais da Doença de Celíaca podem prejudicar a qualidade de vida do paciente que apresentam queixas de desconforto proveniente dessas lesões. Portanto, torna-se imprescindível que os profissionais da saúde estejam familiarizados com essas desordens, uma vez que as lesões orais podem servir como indicadoras fundamentais no diagnóstico precoce da doença.
“Lynch Culture” as an Unlawful Practical Tool of Directing Masses and Individuals: Ancient Rome (Republican Period) Example
Authors: GÜNDAY Onur
Published: September 2022

The lynching movements, which are often seen in modern societies, for personal and political reasons, oriented towards individuals and groups physically or verbally, have been known in various societies and cultures throughout history. These kinds of practices, aimed at destroying or socially intimidating people and groups in the target, have emerged as a different but effective way for people and political groups to go beyond the boundaries of the defined law to provide their justice or political goals. Looting and intimidation of people or political rivals who do not comply with the norms set by society has been an essential factor in the Roman Empire of the Republican Period. It can be seen that these methods, which can be considered as primitive and cruel practices with a contemporary perspective, were referred to legal channels in ancient Rome in many cases or were accepted by the community layers and even by official institutions due to established practices (mos maiorum).
Nutritional Support in Complex Treatment New Coronavirus Infection in COVID-19 Patients and Own Regional Observations (Analytical Review)
Authors: Abdimomunova B. , Zholdoshev S.
Published: September 2022

Monitoring and evaluation of the effectiveness of nutritional support for patients with post-COVID syndrome, and therapy and therapeutic diets for the new coronavirus infection COVID-19 were carried out. In each patient, before starting nutritional support, it is important to calculate the true energy requirement as a basal metabolic rate and corrections taking into account the patient's activity factor, risk factor, underweight and damage factor. The calculation of the need for energy and protein in patients with overweight was calculated on the recommended, and in patients with underweight — on the actual body weight. The diet was considered balanced when: proteins provide 10–15%, fats 20–30%, and carbohydrates 55–70% (10% simple carbohydrates) of calories.
Features of Changes in the Process of Metabolism in Elderly and Senile Age During Different Periods of the Year
Authors: Zhalalova G. , Zholdoshev S.
Published: September 2022

The article presents the results of changes in the process of metabolism (protein metabolism) in the elderly and senile population. The paper studies the peculiarities of changes in the process of protein metabolism in the elderly and senile people living in the southern region of Kyrgyzstan in different periods of the year. People of elderly and senile age react acutely to seasonal fluctuations. Seasonal changes in the environment affect the regulation of the rhythm of life. In the cold period of the year, under the influence of seasonal factors, a decrease in the functional state of the body systems is observed in the elderly and senile population. At different periods of the year and with age, a weakening of the body's metabolism, including protein synthesis, can be observed. Functional and structural changes in the liver, kidneys are completely reduced in the elderly and the elderly compared to young people. Blood tests by biochemical methods at different periods of the year provide a complete assessment of the physiological state of the elderly and seniors.
Prevalence of Healthcare-Associated Infections Among Newborns in Maternity Hospitals of the Kyrgyz Republic
Authors: Sorombaeva N. , Temirov N. , Asyranova U. , Temirova V. , Abdyrayeva B. , Zholdoshev S. , Mamatkulova N.
Published: September 2022

The strategic objective of healthcare is to ensure the quality of medical care and create a safe environment for patients and staff in organizations engaged in medical activities. Infections associated with the provision of medical care are the most important component of this problem due to the widespread negative consequences for the health of patients, staff and the economy of the state. Currently, the problem of prevention and control of infections associated with the provision of medical care remains relevant, because reflects the quality of medical care provided to the population and causes significant economic damage to the country’s healthcare. Infections associated with the provision of medical care is a term for a group of infections, which displays a modern understanding of hospital-acquired infections in accordance with international approaches. The general criterion for classifying infections as infections related to medical care is that their occurrence is associated with the provision of medical care (treatment, diagnosis, prevention, etc.). The largest number of healthcare-associated infections in Kyrgyzstan is registered annually in maternity hospitals and accounts for 33.0% of all cases of this group of infections. As before, the risk of infection with hospital strains of microorganisms remains high in the departments of newborns and premature infants, intensive care units and intensive care units, and according to official statistics, the frequency of healthcare-associated infections in newborns is 16.8%. According to selective studies, the true incidence of infections associated with medical care in maternity institutions is several times higher than the officially registered one, cases of concealing cases of morbidity among newborns and maternity hospitals are not uncommon.
Peculiarities of Fasting-Mimicking Diet (FMD) Management
Authors: Evseev A.
Published: September 2022

The article discusses the specifics and results of the fasting-mimicking diet (FMD) in both healthy people and patients with various diseases, including type 2 diabetes mellitus (T2DM). The special role of FMD in reducing risk factors for the development of chronic diseases is emphasized; the paper substantiates the safety and reasonability of the use of FMD in the form of five-day cycles for four months. The article points out the positive effect of FMD on human anthropometric parameters and biochemical status.
Vegetarianism and Its Influence on Human Body
Authors: Evseev A.
Published: September 2022

The article discusses various points of view on the use of vegetarianism as a nutrition system that involves different types of diets. The paper considers their specifics and looks into the results. The author attempts to evaluate the part of vegetarianism in preventing the development of various chronic diseases of the cardiovascular system, non-alcoholic fatty liver disease, cancer, metabolic syndrome, and adult-onset diabetes mellitus (T2DM). A positive effect of a vegetarian diet on blood lipids has been noted. At the same time, the paper emphasizes the possible drawbacks of vegetarianism which deal with a proven deficiency of vital micronutrients, in particular, calcium, zinc, vitamins B and D.
Could Hemogram Parameters Predict Extensive Pulmonary Involvement in SARS CoV-2 Infection?
Authors: COŞGUN Zeliha , KALFAOĞLU Melike Elif , DAĞISTAN Emine , ÖZSARI Emine , AKTAS Gulali
Published: September 2022

Aim: Since the start of the pandemic, the novel coronavirus infection SARS CoV-2 has caused huge morbidity and mortality, as well as a significant economic cost. We aimed to compare clinical and laboratory findings of the SARS CoV-2 patients with mild pulmonary involvement to those in subjects with advanced pulmonary involvement.

Material and Methods: In this study, the relationship between hemogram indices and pulmonary involvement in patients hospitalized for SARS CoV-2 infection at Bolu Abant Izzet Baysal University Hospital was investigated. We analyzed the thorax CT images of the subjects with SARS CoV-2 in present retrospective study. Radiological pattern of disease-related in the lungs, percentage of lung involvement, hemogram parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), aspartate and alanine transaminases (AST and ALT), lactate dehydrogenase (LDH), D-dimer, ferritin, total bilirubin, albumin, creatinine kinase, serum creatinine in patients with advanced and mild pulmonary involvement were compared.

Results: Advanced pulmonary involvement (greater than 50%) was positively and significantly correlated with ESR, (r=0.32, p
COVID-19’da Ağız Sağlığı Durumu
Authors: UZAN Gulfidan , TEKDEMİR Zeynep , KAR Bedriye , SÖNMEZ Mehmet
Published: September 2022

Amaç: Çin'in Wuhan kentinde 2019 yılının sonlarında koronavirüs hastalığı salgını (COVID-19) ortaya çıkmış ve yalnızca Çin'de değil, tüm dünyadaki ülkelerde de büyük bir halk sağlığı sorunu haline gelmiştir. Ağır akut solunum hastalığı (Severe Acute Respiratory Syndrome causing Coronavirus) (SARS-CoV-2)’nin ağız ve burun yoluyla bulaştığı ve en çok solunum sistemini etkilediği düşünülmektedir. Ağız sağlığı durumunun enfeksiyon oluşumunu ne şekilde etkilediği ise bilinmemektedir. Bu amaçla bu çalışmada COVID-19 olan ve olmayan kişilerde ağız sağlığı durumunun incelenmesi amaçlandı.

Gereç ve Yöntemler: Çalışmaya COVID-19 tanısı almış 101 hasta ile, COVID-19 tanısı almamış 72 gönüllü dahil edildi. Akciğer görüntülemeleri yapıldıktan sonra tüm hastalara ağız sağlığını değerlendirmek için hazırlanan anket soruları sorulup skorlandı. COVID-19 olan ve olmayan gruplar toplam ağız sağlığı skorları ve parametreleri ile radyolojik tutulum açısından karşılaştırıldı.

Bulgular: Hasta ve kontrol gruplarının yaş ortalamaları benzer idi. COVID-19 olan hastaların toplam ağız sağlığı skor değerleri, kontrol grubuna göre olumlu yönde daha yüksekti (p=0,011). COVID-19 grubunda diş fırçalama (p=0,045) ve diş hekimine gitme (p=0,015) oranı istatistiksel olarak anlamlı derecede yüksek iken, diş kaybı (p=0,008) ve ağız kokusu varlığı (p
Drug-Drug Interaction of Aldehyde Oxidase Inhibitor and Xanthine Oxidase Inhibitor with Favipiravir
Authors: AŞKIN ÖZEK Dilan , KESKİN Zeliha , YÜCE Hande , BAŞAK TÜRKMEN Neşe , ASLAN Sümeyye , ÜNÜVAR Songül
Published: September 2022

Aim: Favipiravir is an effective antiviral used in the treatment of COVID-19. It is metabolized by aldehyde oxidase (AO) and xanthine oxidase (XO). This study investigated drug-drug interactions between favipiravir with both AO substrate and XO enzyme inhibitor, allopurinol, and an XO inhibitor, verapamil.

Material and Methods: 25 Sprague-Dawley female rats, 250-300 g, were divided into five equal groups. Blood samples were taken from the jugular vein at the end of 0, 15, 30, and 45 minutes, and at the end of the 1st, 2nd, 4th, 6th, and 8th hours after the drugs were administered. The drug-blood concentration was determined in the HPLC-UV device using plasma. The ELISA method measured AO and XO enzyme activities in rat liver tissue.

Results: Allopurinol prolonged the time taken for favipiravir to reach Cmax (Tmax), decreased maximum serum concentration (Cmax), elimination half-life (T1/2), area under the curve (AUC), and mean residence time (MRT). Allopurinol significantly reduced clearance per unit time (Cl/f) when co-administered with favipiravir. Verapamil accelerated the elimination of favipiravir, significantly reducing T1/2, MRT, and AUC. On the other hand, Favipiravir decreased the absorption of verapamil and slowed its elimination. Cmax, AUC, and Cl values of verapamil decreased. In addition, T1/2, MRT, and volume of distribution (Vd) increased.

Conclusion: In conclusion, the concomitant use of favipiravir with other drugs that affect AO and/or XO enzyme activities may cause changes in the pharmacokinetic profiles of drugs and the levels of enzymes that metabolize drugs.
Investigation of the Effect of Leaky Gut on COVID-19 Clinic
Authors: ÖZTÜRK Cihadiye , KESKİN Banu Hümeyra , INCE Nevin , KAYABAŞI Eda , KAYA Sare , CANGÜR Şengül , YILDIZ GÜLHAN Pınar , DEMİR Mehmet Cihat
Published: September 2022

Aim: In the course of the COVID-19 pandemic, in millions of cases were observed those of some patients do not exhibit any symptoms whereas some others are hospitalized with having fatal outcomes. One of the most significant findings is that patients with existing comorbidities are extremely exposed to severe clinical conditions developed due to excessive inflammatory response. That is to say, the indicative cause of chronic inflammation may be bacterial translocation derived from the impaired intestinal mucosal barriers.

This study is aimed to investigate the probable relations between the impaired intestinal barrier integrity and which would be associated with severity of COVID-19 clinical conditions.

Material and Methods: According to the clinical and laboratory findings, the patients were classified into three groups as mild, moderate, and severe clinical conditions. All patients’ blood samples were collected on the first admission to the hospital. Serum concentrations of lipopolysaccharide-binding protein (LBP), were analyzed to evaluate the intestinal barrier function and bacterial translocation.

Results: The proportions of those with high LBP levels among all the groups were significantly different (p
Effect of the Subjective Well-Being of Working Women on Their Online Shopping Addiction during the COVID-19 Pandemic
Authors: AYHAN Didem , SEKİ ÖZ Hilal
Published: September 2022

Aim: Especially in the first year of the COVID-19 pandemic, the time spent at home and on the internet has increased, social activities have decreased, and this process has been also accompanied by several mental problems. This study aimed to explore the effect of the subjective well-being of working women on their online shopping addiction status during the COVID-19 pandemic.
Material and Methods: The sample of this study comprised 538 women who had a formal job. The data were collected online platform using a socio-demographic information form, the Subjective Well-Being Scale, and the Online Shopping Addiction Scale. The statistical analyses were conducted using IBM Statistical Package for the Social Sciences (SPSS) 25.0 for Windows, and Jeffreys’s Amazing Statistics Program (JASP) 0.1.4.0. Descriptive statistical tests of research data; presented with frequency, percentage, mean and standard deviation. Also, partial correlation and multiple linear regression enter method analyzes were performed to examine the relationship between the variables.
Results: It is found that the subjective well-being of the participants predicted their overall online shopping addiction levels and their levels regarding the components of online shopping addiction. It was explained by 16.4% of the variance in online shopping addiction, 17.1% of the variance in emotional addiction, 15.3% of the variance in social addiction and only 10.1% of the variance in control addiction by subjective well-being.
Conclusion: According to the results, it may be asserted that working women turn toward online shopping to enhance their subjective well-being during the COVID-19 pandemic period.
Renal Hücreli Karsinomlarda Patolojik Prognostik Parametrelerin Değerlendirilmesi: Tek Merkez Deneyimi
Authors: KANTARCIOĞLU COŞKUN Sinem
Published: September 2022

Amaç: Böbrek kanserleri dünyada en sık görülen kanserler arasındadır. Sosyoekonomik gelişme durumlarına göre farklılıklar göstermekle birlikte pek çok ülkede insidans ve mortalite oranları artmaktadır. Bu çalışmada renal hücreli karsinomların (RHK) patolojik prognostik parametrelerini literatür bilgileri eşliğinde değerlendirmek amaçlanmıştır. Gereç ve Yöntemler: RHK tanısı alan toplam 105 olgu çalışmaya dahil edildi. Hastalara ait yaş, cinsiyet, ameliyat tipi (parsiyel/total rezeksiyon), patolojik tanı, tümör lokalizasyonu, makroskopik tümör görünümü, tümör sınırları (düzenli/düzensiz), tümör derecesi, tümör büyüme paterni, tümör çapı, renal kapsül invazyonu, perirenal yağ dokusu invazyonu, renal ven invazyonu, tümörde nekroz ve kistik dejenerasyon varlığı, patolojik tümör evresi, üreter cerrahi sınır, adrenal bez tutulumu ve metastatik tümör durumu verileri hasta dosyalarından ve patoloji raporlarından retrospektif olarak elde edildi. Prognostik parametreler gözden geçirildi. Bulgular: Olguların 71’i erkek, 34’ü kadındı. Yaş aralığı 26 ile 87 arasındaydı. En sık görülen alt tip berrak hücreli olup (n=80), onu papiller tip 1 (n=12), kromofob (n=8) ve papiller tip 2 (n=5) RHK’lar takip ediyordu. Tümör çapı 1,7 cm ile 17 cm arasındaydı. Olguların %71,1’inin nükleer derecesi 2 olarak izlendi. 27 olguda renal kapsül invazyonu mevcut olup, perirenal yağ doku invazyonu 19 olguda görüldü. Sonuç: RHK’lar farklı histolojik alt tiplere sahip, ayırt edici genetik ve moleküler değişiklikler içeren, farklı klinik davranışları nedeniyle terapilere farklı yanıtlar veren hastalıkların bir spektrumudur. Bireyselleştirilmiş surveyans protokolleri oluşturmada, hasta danışmasında ve gelecekteki potansiyel adjuvan tedaviyi belirlemede prognostik parametreler önemli role sahiptir.
Üniversite Öğrencilerinin Sağlık Okuryazarlık Düzeyleri ve İlişkili Bazı Faktörler
Authors: GÜZEL Aysun , TURAN Sevgi , ÜNER Sarp
Published: September 2022

Amaç: Bu araştırmanın amacı bir üniversitede öğrenim gören öğrencilerin sağlık okuryazarlığı düzeylerinin ve ilişkili bazı faktörlerin belirlenmesidir. Gereç ve Yöntemler: Tanımlayıcı tipteki araştırmanın evrenini, 1 Ocak - 11 Mayıs 2018 tarihlerinde bir üniversitenin Sağlık Bilimleri Fakültesi ve İktisadi ve İdari Bilimler Fakültesinde öğrenimine devam eden toplam 2400 öğrenci oluşturmuştur. Çalışma 865 öğrenci ile (katılım düzeyi %36) tamamlanmıştır. Araştırmada Türkiye Sağlık Okuryazarlığı Ölçeği-32, Çok Boyutlu Sağlık Kontrol Odağı Ölçeği A Formu ile öğrencilerin bazı sosyodemografik özelliklerini sorgulayan 15 soruluk anket formunu içeren veri toplama aracı kullanılmıştır. Veriler SPSS 22.0 programında yüzdelik, ortalama, tek yönlü varyans analizi, post-hoc testleri, bağımsız örneklem t-testi, korelasyon ve lojistik regresyon kullanılarak analiz edilmiş ve p<0,05 olan değerler anlamlı kabul edilmiştir. Bulgular: Araştırmaya katılan öğrencilerin %72,4’ü kadındır. Araştırmaya katılan öğrencilerin Sağlık Okuryazarlığı Ölçeği toplam puan ortalamaları 31,54±11,4; tedavi ve hizmet alt boyutu puan ortalamaları 32,58±10,9; hastalıklardan korunma ve sağlığın geliştirilmesi alt boyut puan ortalamaları 30,80±12,0 olarak bulunmuştur. Kadınların erkeklere göre sağlık okuryazarlığı toplam puanlarının yeterli olma olasılığı 0,624 kat (%95 GA=0,440-0,885) fazla bulunmuştur. İç kontrol odağı alt boyutu puanı bir birim arttığında tedavi ve hizmet alt boyutu puanlarının yeterli olma olasılığı 1,045 kat artmaktadır (%95 GA=1,013-1,077). Sonuç: Cinsiyet, gelir durumu, kronik hastalık varlığı, algılanan sağlık durumu, öğrencilerin algısına göre aileden, arkadaşlardan ve sağlık personelinden alınan sosyal destek durumu ile Çok Boyutlu Sağlık Kontrol Odağı Ölçeği A Formu iç kontrol odağı öğrencilerin sağlık okuryazarlığı ile ilişkili olan bazı değişkenlerdir.
Investigation of the Effect of Different Surface Treatments on Shear Bond Strength in the Fabrication of Metal-Ceramic Dental Restorations
Authors: KARA Recep
Published: September 2022

Aim: The bond strength between metal and porcelain is an essential factor for the success of metal-ceramic restorations. Therefore, this study evaluated the shear bond strength (SBS) between ceramic and cobalt-chromium (Co-Cr) alloys after oxidation treatment. Material and Methods: A total of 150 Co-Cr samples, 50 samples each, were produced from casting, laser sintering, and milling techniques. The primary group samples produced were divided into five subgroups. One of the subgroups is sandblasted with 110 µm Al2O3, and the others are ground with carbon separator disc, sintered diamond bur, tungsten carbide bur, and pink stone in one direction. SBS test was applied after the oxidation and veneering process. After debonding, digital microscopy investigated the surface characterizations of Co-Cr alloys. For the normality distribution of SBS measurements, the Kolmogorov-Smirnov test was used. According to the results, non-parametric tests were used in the study because the distribution was not suitable for the normal distribution, and the number of samples within the group was low in the subgroups. Kruskal Wallis and All pair-wise post hoc test (α = 0.05) were used for analysis. Results: There was a statistical difference between the laser sintering and milling groups according to the fabrication techniques. The highest SBS value was found in the Al2O3 laser group (34.35) and the lowest in the Al2O3 casting group (17.68). Surface treatments significantly altered ceramic adhesion. Almost all subgroups exhibited mixed failure. All of the SBS values found in this study were almost clinically acceptable. Conclusion: As different abrasives in the leveling and finishing of metal substructures may affect the metal-ceramic bonding, care should be taken in their use as much as possible.
Glutensiz Diyetin Mikrobiyotaya Etkisi
Authors: BÜYÜK Nurbanu , AYYILDIZ Feride
Published: September 2022

Glutensiz diyet, buğday, arpa, çavdar ve ürünlerini içermeyen beslenme modeli olarak tanımlanmaktadır. Çölyak tanısı alanlar veya gluten intoleransı olan bireylerde yaşam boyu uygulanması gereken terapötik bir yaklaşımdır. Ancak son dönemde sağlıklı bireyler gaz, şişkinlik gibi şikayetlerin azaltılması ve vücut ağırlığı kaybının sağlanması amacıyla sıkça glutensiz diyet uygulayabilmektedir. Bu uygulamanın sağlık üzerine olumlu veya olumsuz etkileri netlik kazanmasa da mikrobiyota üzerine etkileri güncel çalışmalarla incelenmektedir. Bağırsak mikrobiyotası; zararlı veya faydalı metabolitler üreterek insan sağlığını etkileyen ve patojenlere karşı koruyan, bağışıklık sistemine katkısı olan ve gastrointestinal gelişimi düzenleyen bir organ olarak tanımlanmaktadır. Çölyak hastaları gibi glutensiz diyet uygulaması gereken bireylerde glutensiz diyetin, mikrobiyotadaki disbiyoz durumunu kısmen veya tamamen düzelttiği bildirilmiştir. Ayrıca çölyak hastalığında glutensiz diyete ek olarak probiyotik desteğinin bağırsak homeostazının yeniden sağlanmasına yardımcı olduğu belirtilmektedir. Tam tersine sağlıklı bireylerde glutensiz diyet uygulamasının mikrobiyotada disbiyoza neden olduğu rapor edilmiştir. Bu etkinin glutensiz diyetin kompleks karbonhidrat ve bitkisel protein içeriğinin düşük, yağ içeriğinin ise yüksek olmasıyla ilişkili olduğu vurgulanmaktadır. Sonuç olarak glutensiz diyet bağırsak mikrobiyotası üzerinde etkili olup, çölyak hastalığı olanlar ve sağlıklı bireyler üzerine etkisi farklı olabilmektedir. Özellikle sağlıklı bireylerde yapılan çalışmalarda örneklem sayısının az olması ve uygulama sürelerinin kısa olması nedeniyle sınırlılıkları mevcuttur. Glutenin mikrobiyota üzerine etkisinin değerlendirilmesinde net bir mekanizma ve verilere ulaşılması için daha fazla çalışmaya ihtiyaç vardır.
Şizofreni veya Bipolar Bozukluk Tanılı Ebeveyn Çocuklarının Yaşam Deneyimleri
Authors: KONUK ŞENER Dilek , KARACA Aysel
Published: September 2022

Ebeveynde ruhsal hastalık tanısı bulunması hem çocuk hem de ebeveyn için oldukça sıkıntılı yaşam deneyimlerine sebep olabilmektedir. Şizofreni ve/veya bipolar bozukluk ile takip edilen anne/baba çocuklarının bireysel ve toplumsal birçok zorlukla mücadele ettikleri bilinmektedir. Her çocuğun yaşam deneyimi eşsiz ve özel olsa da aralarında dramatik benzerlikler olduğu görülmektedir. Çocuklar korku, utanma, üzüntü, umutsuzluk gibi duygular yaşamakta; kişilerarası uyumsuzluk, saldırganlık, davranış bozukluğu, düşük benlik saygısı ile karakterize çeşitli sosyal problemler ile karşılaşmakta; stigmaya maruz kalmakta ve erken dönemde ağır sorumluluklar altına girmektedirler. Kullandıkları baş etme stratejilerinin ise maladaptif (sigara/alkol kullanımı, evden kaçma düşüncesi, içe kapanma vb) olduğu görülmektedir. Bu olumsuz etkilere rağmen, bazı çocuklarda problem çözme becerilerinin gelişmesi, özgüvenlerinin ve bağımsızlıklarının artması gibi olumlu etkilerde görülebilmektedir. Bu makalede, şizofreni ve/veya bipolar bozukluk tanılı ebeveyn çocuklarının yaşam deneyimleri ve gereksinimleri incelenerek, hemşirelerin rolünün tartışılması amaçlanmaktadır. Bu çocukların yaşam deneyimlerinin öğrenilmesinin, aile işlevselliğinin artırılması, gereksinimlerinin karşılanabilmesi ve baş etme becerilerinin geliştirilebilmesi için hemşirelik girişimlerinde yol gösterici olacağı düşünülmektedir.
Competency Standardization for Indonesian Tourism Human Resources: Implementation in Education, Training and Competency Certification
Authors: Sukma Yudistira
Published: September 2022

The increasing trend of Indonesia's tourism competitiveness has placed it as one of the priority industrial sectors in Indonesia. However, this achievement is not in line with increasing the competitiveness of human resources (HR). The national work competency standardization system (SKKN), which the Indonesian Government has implemented since 2012, has not been effective, and human resources' competitiveness has even shown a negative trend. It is feared that this situation will hamper the growth rate of Indonesia's tourism competitiveness in the future. The purpose of this study is to critically analyze the application of the SKKNI system, which is focused on education, training, and competency certification of Indonesian tourism human resources, to uncover the inhibiting factors for its implementation. This education, training, and competency certification are the main components in the performance of the SKKNI system in Indonesia. The research was carried out by reviewing the relevant literature, analyzing the processes and elements in applying the SKKNI system. Research data is secondary data collected from data sources of Government and non-government institutions and scientific and non-scientific literature available on official government websites and the internet. The research results are then triangulated to get a comprehensive picture and understanding of the application of the SKKNI system. The results showed that the implementation of the SKKN system was effective in increasing the capacity of Indonesian tourism human resources but has a tiny growth Quantitatively. The main obstacle is limited trainer, assessor, facilities, and educational, training, and certification institutions to produce trained and certified human resources of tourism.
Planning and Implementation of Hybrid Event Case Study: Muslim Fashion Festival (MUFFEST), March 18-28, 2021 in Jakarta
Authors: Fetty Nurmala Rossi  , I Made Adhi Gunadi  , Hasnah Amirah Kirana
Published: September 2022

This study aims to analyze the planning and implementation of Hybrid Event in Jakarta "Muslim Fashion Festival (MUFFEST) 2021" in Kota Kasablanka Mall and to identify the hybrid elements used during the event. This research method uses qualitative descriptive with a case study approach. Sources of data are obtained through observations with field notes, interviews, and documentation. Data collection techniques used in this study are: interviews with key informants such as Organizer, Supplier, and Venue. Also, literature study was used for qualitative data. This study indicates that the planning and implementation of the event has met all the required aspects. In the hybrid element, this event is also broadcast via live streaming on YouTube, Zoom, Instagram, and the V-Mix application. This study recommends incorporating hybrid elements, such as applications that support virtual exhibition activities and examine the experience of visitors attending the Hybrid Event..
Moral Stances and the Preservation of Political Trust during the Pandemic
Authors: Liu Frank C. S.
Published: September 2022

This study is built upon an analysis of web survey data collected in 2022 when the pandemic crisis escalated in Taiwan. This study utilizes multiple correspondence analysis to explore the latent associations between pairs of variables, particularly social media use, opinions about vaccine policies, moral stances, and political trust. The results are expected to show the patterns that meet democratization scholars’ expectations and those that go beyond existing theoretical reasoning.
Asymmetries and relationships between muscle strength, proprioception, biomechanics, and postural stability in patients with unilateral knee osteoarthritis
Authors: Zeng Ziquan , Shan Jiaxin , Zhang Yilong , Wang Yi , Li Congcong , Li Junyi , Chen Weijian , Ye Zixuan , Ye Xiangling , Chen Zehua , Wu Zugui , Zhao Chuanxi , Xu Xuemeng
Published: September 2022

Background: The pathological mechanism of knee osteoarthritis (KOA) is unknown. KOA degeneration may be associated with changes in muscle strength, proprioception, biomechanics, and postural stability.

Objective: This study aimed to assess asymmetries in muscle strength, proprioception, biomechanics, and postural stability of bilateral lower limbs in patients with unilateral KOA and healthy controls and analyze correlations between KOA and these parameters.

Methods: A total of 50 patients with unilateral KOA (age range: 50-70) and 50 healthy subjects were recruited as study participants (age range: 50-70). Muscle strength, proprioception, femorotibial angle (FTA), femoral condylar–tibial plateau angle (FCTP), average trajectory error (ATE), and center of pressure (COP) sways areas were accessed in study participants, and the correlation between these variables was investigated.

Results: In patients with unilateral KOA, lower limb muscle strength was significantly lower on the symptomatic side than on the asymptomatic side (p < 0.01), while the proprioception (degree error), FTA, FCTP, and ATE were substantially higher compared to the asymptomatic side (p < 0.01). However, no significant difference was observed in the healthy controls (p > 0.05). Patients with unilateral KOA had lower muscle strength than healthy controls (p < 0.05), but their proprioception (degree error: the difference between the target and reproduction angles), ATE, and COP sway areas were higher (p < 0.05). Muscle strength was found to be negatively correlated with ATE and COP sways areas (p < 0.05), whereas proprioception (degree error) was positively correlated with ATE and COP sways areas (p < 0.05) in all study participants. However, no correlation was found between FTA, FCTP, and ATE, COP sways areas in patients with unilateral KOA (p > 0.05).

Conclusion: In patients with unilateral KOA, muscle strength, proprioception, biomechanics, and postural stability of bilateral limbs are asymmetrical in unilateral KOA patients. Muscle strength, proprioception, and postural stability are significantly associated variables, and changes in these variables should be considered in KOA prevention and rehabilitation.
Identifying the relationship between VOCs emission and temperature/humidity changes in new apartments in the hot desert climate
Authors: Jung Chuloh , Mahmoud Naglaa Sami Abdelaziz , Alqassimi Nahla
Published: September 2022

Much previous research in different countries describes a strong dependence on temperature and humidity for indoor air pollutants generated from building materials. Since many types of building materials are complexly applied in residential buildings in UAE and are constantly using air-conditioning, the result might be different from the characteristics of indoor air pollutants from a small chamber experiment. This paper aims to investigate the relationship between the concentration of indoor air pollutants according to changes in temperature and humidity in newly built apartments before moving in. As a methodology, a field measurement was performed in 23 housing units in five different residential towers in Ajman, United Arab Emirates. Before the measurement, a 7-day bake-out was completed, and the target units were measured 30 days before moving in. The result showed that formaldehyde (HCHO) and VOCs such as benzene (C6H6), toluene (C7H8), ethylbenzene (C8H10), xylene (C8H10), and styrene (C8H8) have consistent humidity dependence within the range of 15 %–60% of relative humidity (RH). It was impossible to confirm the temperature dependency since it showed different characteristics for each apartment between 22°C and 33°C. There is a limit to predicting the occurrence of indoor air pollutants in the apartment only with microclimatic factors since there are many other variables, such as various building materials, management history of materials, and construction methods. However, it was proven that there is an emission cut-off point where the generation of indoor air pollutants deviates from a linear relationship in the RH 40%–50% and 25°C. These temperature and humidity ranges are synchronized with daily life ranges.
Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
Authors: Shi Xiyao , Wang Ying , Zhang Longhui , Zhao Wenjie , Dai Xiangpeng , Yang Yong-Guang , Zhang Xiaoling
Published: September 2022

Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by recognizing acetylation of histones and non-histone proteins including transcription factors, which subsequently promote tumor cell proliferation, survival, metastasis and immune escape. Therefore, BET family proteins are considered attractive therapeutic targets in various cancers. Currently, blocking of the BET proteins is a widely used therapeutic strategy for MYCN amplified high-risk neuroblastoma. Here, we summarized and reviewed the recent research progresses for the critical function of BET proteins, as an epigenetic reader, on tumorigenesis and the therapeutic potential of the BET/BRD4 inhibitors on MYCN amplified neuroblastoma. We also discussed the combined therapeutic strategies for BET inhibitor-resistant neuroblastoma.
Mathematical models of nitrogen-fixing cell patterns in filamentous cyanobacteria
Authors: Casanova-Ferrer Pau , Muñoz-García Javier , Ares Saúl
Published: September 2022

The Anabaena genus is a model organism of filamentous cyanobacteria whose vegetative cells can differentiate under nitrogen-limited conditions into a type of cell called a heterocyst. These heterocysts lose the possibility to divide and are necessary for the filament because they can fix and share environmental nitrogen. In order to distribute the nitrogen efficiently, heterocysts are arranged to form a quasi-regular pattern whose features are maintained as the filament grows. Recent efforts have allowed advances in the understanding of the interactions and genetic mechanisms underlying this dynamic pattern. Here, we present a systematic review of the existing theoretical models of nitrogen-fixing cell differentiation in filamentous cyanobacteria. These filaments constitute one of the simplest forms of multicellular organization, and this allows for several modeling scales of this emergent pattern. The system has been approached at three different levels. From bigger to smaller scale, the system has been considered as follows: at the population level, by defining a mean-field simplified system to study the ratio of heterocysts and vegetative cells; at the filament level, with a continuous simplification as a reaction-diffusion system; and at the cellular level, by studying the genetic regulation that produces the patterning for each cell. In this review, we compare these different approaches noting both the virtues and shortcomings of each one of them.
MicroRNAs: Emerging players in the pathogenesis of vitiligo
Authors: Yu Xin , Cui Yuli , Zhu Xueqing , Xu Hongjun , Li Linfeng , Gao Guangcheng
Published: September 2022

Vitiligo is an autoimmune skin disease characterized by presence of pale patchy areas of depigmentation. MicroRNAs (miRNAs) are important regulators of gene expression and play significant roles in diverse biological and pathological processes. Accumulating evidence has shown that miRNAs were differentially expressed in skin lesions and peripheral blood mononuclear cells of patients with vitiligo. In particular, miRNAs are significantly correlated with the development and progression of vitiligo. The abundance of some miRNAs in serum was also correlated with the vitiligo lesion severity, indicating that miRNAs might serve as prognostic biomarkers. Importantly, the direct involvement of miRNAs in the pathogenesis of vitiligo has been demonstrated. For example, increased expression of miR-25 contributes to vitiligo through promoting the dysfunction and oxidative stress-induced destruction of melanocytes. However, there are limited studies on the function and mechanism of deregulated miRNAs in vitiligo. Further studies are required to establish clinical applications of miRNAs for vitiligo. More in-depth investigations of miRNAs are needed for the understanding of the pathogenesis of vitiligo and the development of novel therapeutic targets. This present review summarizes the current literature on the deregulation and pathogenic roles of miRNAs in vitiligo. We also highlight the potential clinical applications of miRNAs in patients with vitiligo.
Research on alkali metal-modified Pd catalyst for oxygen removal from propylene
Authors: Zhao Jinchong , Jiang Jie , Wen Song , Zhang Jing , Zhang Changsheng , Sheng Nan , Liang Wei , Sun Bing , Xu Wei , Yang Zhe , Pan Yuan
Published: September 2022

A series of alkali metal (Li, Na, and K)-modified Pd catalysts and Pd/Al2O3 were prepared and used to remove oxygen in a propylene flow with hydrogen’s existence. The results showed that the alkali metals could enhance the performance of the Pd catalysts and the effect followed the order of K > Na > Li. X-Ray diffraction (XRD), N2-physisorption, transmission electron microscopy (TEM), hydrogen temperature programmed reduction (H2-TPR), and X-ray photoelectron spectroscopy (XPS) were carried out to investigate the alkali metal-modified Pd catalysts and the promotional effect mechanism was explained. The results showed that alkali metal modification increased the electron density of Pd atoms to induce the negatively charged Pd species, which could enhance the adsorption of oxygen while weakening the adsorption of propylene, and then enhance the performance of the modified catalysts for oxygen removal from unsaturated hydrocarbon. The Pd-K/A catalyst performed the best on both oxygen removal and propylene hydrogenation inhibition.
Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?
Authors: Scariot Debora B. , Staneviciute Austeja , Zhu Jennifer , Li Xiaomo , Scott Evan A. , Engman David M.
Published: September 2022

Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment.
Changes in the seroprevalence and risk factors between the first and second waves of COVID-19 in a metropolis in the Brazilian Amazon
Authors: da Silva Torres Maria Karoliny , Lopes Felipe Teixeira , de Lima Aline Cecy Rocha , Cordeiro Lima Carlos Neandro , dos Santos Brito Wandrey Roberto , Gonçalves Janete Silvana S. , dos Santos Oliveira Onayane , de Oliveira Freitas Vanessa , dos Santos Bernardo Cintra , Santos de Sousa Renata , Carvalho Gomes Jayanne Lilian , Sarmento Botelho Bruno José , Alves Correa Ana Carolina , Machado Luiz Fernando A. , Martins Feitosa Rosimar Neris , Lima Sandra Souza , Cayres Vallinoto Izaura Maria Vieira , Vallinoto Antonio Carlos R.
Published: September 2022

In Brazil, the coronavirus disease 2019 (COVID-19) epidemic spread rapidly in a heterogeneous way, mainly due to the different socioeconomic and behavioral characteristics of different regional populations and different evaluation periods. We performed a cross-sectional study including 1,337 individuals (first wave = 736/second wave = 601) after the first two waves of COVID-19 in the city of Belém, the capital of the state of Pará. The detection of IgG anti-SARS-CoV-2 antibodies was performed using an enzyme-linked immunosorbent assay test followed by statistical analysis using the RStudio program. Our results showed an increase in the seroprevalence (first wave= 39.1%/second wave= 50.1%) of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies in the population of Belém from the first to the second pandemic wave. Advanced age, primary or secondary education level, lack of social isolation, and a low frequency of protective mask use were considered risk factors for SARS-CoV-2 infection during the first wave compared to the second wave. This study is one of the firsts to provide important information about the dynamics of virus circulation and the groups vulnerable to exposure in the two major periods. Our data emphasize the socioeconomic characteristics of the affected population and that nonpharmacological prevention measures are crucial for combating the pandemic.