bluuebunny/crossref_metadata_2025 huggingface dataset:
Strengthening Judicial Commission Authority in Indonesia Judicial Power Institutions, Link to Trias Politica Theory
Authors: Darusman Yoyon Mulyana , Soriano Elmer Micu , Nunna Bhanu Prakash
Published: May 2024

The People’s Consultative Assembly amended the 1945 Constitution to improve various aspects related to Indonesia's downturn. One crucial demand is improvement in law enforcement so that it is more independent from the interference of other powers outside the judiciary. The practice of judicial power in the New Order era was carried out under two institutional roofs. Powers relating to judicial processes and law enforcement in the courts were under the roof of the Supreme Court, while powers relating to the budget in the judicial process were under the roof of the Ministry of Justice. The 3rd amendment to the 1945 Constitution has placed the Supreme Court and the Constitutional Court as holders of judicial powers and the Judicial Commission as stipulated in Article 24 of the 1945 Constitution. It has placed the Judicial Commission as an institution with the authority to supervise judges, as Article 24 B of the 1945 Constitution stipulated. The research method uses a normative approach with a qualitative research model. The model of qualitative research is an approach to implementing research purposed toward natural phenomena or symptoms. Results of this research show there has been an imbalance in position between the Supreme Court, the Constitutional Court, and the Judicial Commission, which, in the end, the supervisory function of judges, which is the task of the Judicial Commission, becomes less than optimal and needs to be strengthened.
Inkosistensi Mahkamah Konstitusi tentang Pemberian Kedudukan Hukum Pemohon dalam Putusan Nomor 90/PUU-XXI/2023 dengan Putusan Nomor 74/PUU-XVIII/2020.
Authors: Aji Alan Bayu
Published: May 2024

Kedudukan Hukum Pemohon dalam perkara konstitusi pengujian undang-undang terhadap UUD NRI Tahun 1945 merupakan syarat mutlak. Dalam penelitian ini terdapat dua putusan Mahkamah Konstitusi yang memberikan putusan yang berbeda tentang kedudukan hukum pemohon yaitu putusan Nomor 90/PUU-XXI/2023 dan putusan Nomor 74/PUU-XVIII/2020, di mana dari kedua putusan tersebut memiliki permohonan yang serupa tentang syarat pencalonan presiden dan wakil presiden, namun Mahkamah memberikan putusan kedudukan hukum yang berbeda. Sehingga dalam penelitian ini ada dua rumusan masalah pertama tentang bagaimana kedudukan pemohon dalam putusan Nomor 90/PUU-XXI/2023 dan Putusan Nomor 74/PUU-XVIII/2020, kedua mengenai pandangan Majelis Hakim Mahakamah Konstitusi tentang kedua putusan tersebut. Metode penelitian yang digunakan adalah penelitian yuridis normatif dengan pendekatan kasus (Case Approach). Penelitian ini menemukan bahwa terdapat permasalahan dalam pemberian kedudukan hukum pemohon oleh Mahkamah Konstitusi khususnya dalam Putusan Nomor 74/PUU-XVIII/2020 yang tidak memberikan kedudukan hukum kepada pemohon sedangkan terhadap putusan 90/PUU-XXI/2023 memberikan kedudukan kepada pemohon. Hal tersebut menunjukan sikap Inkosistensi Mahkamah Konstitusi terhadap kedudukan hukum pemohon yang permohonannya merupakan kebijakan hukum terbuka yang itu sebenarnya bukan kewenangan Mahkamah Konstitusi. Mahkamah Konstitusi sebagai penjaga Konstitusi seharusnya menunjukan konsistensi dalam pemberian kedudukan hukum khususnya terkait dengan permohonan yang berkaitan dengan kebijakan hukum terbuka. Kata Kunci:Inkonsistensi; Kedudukan Hukum; Mahkamah Konstitusi.
Implementasi Rumah Restorative Justice Di Kejaksaan Negeri Purbalingga
Authors: Alamsyah Rhaka Fajar , Alhadi Aura Viska Renathya , Santika Nareswari Nindiya
Published: May 2024

Keadilan restoratif ialah konsep yang menitikberatkan pada pemulihan korban sebagai inti utama dalam penegakan hukum, sebuah metamorfosis terhadap keadilan restributif. Dalam hal ini restorative justice menitikberatkan pada bagaimana korban akan didudukkan dan fokus akhir apa yang akan dicapai. Rumah restorative justice dinilai sebagai salah satu bentuk upaya yang dikeluarkan oleh Kejaksaan Agung untuk memfasilitasi penegakan hukum dalam mendukung Keadilan Restoratif / Restorative Justice. Dalam penelitian ini, peneliti mengkaji mengenai bentuk optimalisasi Rumah Restorative Justice pada Kejaksaan Negeri Purbalingga sebagai bentuk penyelesaian perkara tanpa melibatkan pengadilan, dengan menggunakan metode penelitian yuridis normatif dan empiris yang menggunakan jenis penelitian kepustakaan dengan berpedoman kepada asas-asas hukum serta peraturan perundang-undangan di Indonesia dan juga melibatkan beberapa elemen Kejaksaan Negeri Purbalingga sebagai narasumber untuk upaya dalam mengumpulkan data. Hasil penelitian ini menunjukkan bahwa implementasi konsep Restorative Justice di Kabupaten Purbalingga secara konseptual sudah berjalan dengan beberapa peraturan hukum yang mengatur, terbentuknya Rumah Restorative Justice di Kabupaten Purbalingga merupakan realisasi dari Peraturan Kejaksaan Agung sebagai bukti keseriusan Kejaksaan dalam menjalankan salah satu fokus pembangunan hukum di Indonesia. Berdasarkan data yang dipaparkan dalam jurnal penelitian ini menunjukkan hasil bahwa angka penyelesaian perkara secara non-litigasi di Kabupaten Purbalingga masih terbilang cukup rendah dan peranan rumah RJ masih belum teroptimalisasikan secara menyeluruh, sehingga hal ini menjadi menarik perhatian dengan mendasarkan pada fokus utama yang menjadi hambatan penerapan RJ sekurang kurangnya pada dua aspek : culture budaya dan kompleksitas kondisi Tersangka untuk bisa di moderisasi pemulihannya melalui keadilan restorative.
Poly(Vinyl Alcohol) Chemical-Dehydration to Polyacetylene By Fuming Sulfuric Acid
Authors: Carotenuto Gianfranco , Nicolais Luigi
Published: May 2024

Recently, polyacetylene (PA) and polyenes (polyvinylenes) are receiving renewed scientific attention due to their unique physical properties potentially useful also for a number of non-electrical applications (e.g., hydrogen storage, drug delivery, adsorbent of organic compounds in aqueous systems, gas and liquid separation, oxygen absorbent in gas analysis, etc.). These chemical compounds can be obtained in form of a polyacetylene-PVOH copolymers simply by chemical dehydration of poly(vinyl alcohol) (PVOH), which is a very common type of polymer, widely used in different technological areas. This very inexpensive chemical reaction for the large-scale synthesis of PA/polyvinylenes has been investigated by reacting PVOH with fuming sulfuric acid at room temperature. In this process, PVOH, shaped in form of film, is dipped in fuming sulfuric acid (i.e., H2SO4 at 95-97%) and, after complete chemical-dehydration, it has been mechanically removed from the liquid phase by using a nylon sieve. The reduction process leads to a substantial PVOH film conversion to PA as it has been proved by infrared spectroscopy (ATR-mode). Indeed, the ATR spectrum of the reaction product included all characteristic absorption bands of PA. The reaction product has been also characterized by differential scanning calorimetry (DSC) and absorption optical spectroscopy (UV-Vis) in order to evidence respectively its solid-state thermal isomerization (cis-PA conversion to trans-PA) and presence in the structure of conjugated carbon-carbon double bonds of various extensions.
Dual-Polarized Dipole Antenna with Wideband Stable Radiation Patterns Using AMC Reflector
Authors: Lin Xianjing , Mai Jielin , He Hong Jun , Zhang Yao
Published: May 2024

This paper presents a wideband dual-polarized dipole antenna structure operating at 1.7-3.8 GHz (76.4%). For a traditional 4G dipole antenna which covers the band 1.71 GHz- 2.69 GHz, it’s difficult to maintain the satisfactory impedance matching and normal stable radiation patterns within the 5G sub-6 GHz band 3.3-3.8 GHz, which mainly due to the fixed antenna height is no longer a quarter-wavelength. To solve this, a connected-ring-shaped metasurface structure is proposed and deployed to operate as an artificial magnetic conductor (AMC). As a result, stable antenna radiation patterns are obtained within the whole band 1.7-3.8 GHz. For verification, this wideband dipole antenna using AMC is implemented and tested. The measured results show that the proposed antenna has an impedance bandwidth of 80.7% (1.7-4.0 GHz). It has an average measured in-band realized gain of 7.0±1.0 dBi and a stable 70∘±5∘ half power beam width (HPBW) within the 4G/5G-sub 6GHz bands 1710-2690 MHz and 3300-3800 MHz.
Are COVID-19 Polymorphisms in ACE and ACE2 Prognosis Predictors?
Authors: Guarienti Fabiana Amaral , Xavier Fernando Antonio Costa , Ferraz Mateus Duarte , Wagner Fernanda , Marinowic Daniel , da Costa Jaderson Costa , Machado Denise Cantarelli
Published: May 2024

Regardless of the SARS-CoV-2 pandemic containment, it remains paramount to comprehensively understand its underlying mechanisms to mitigate potential future health and economic impacts, comparable to those experienced throughout the course of the pandemic. The angiotensin-converting enzyme 2 (ACE2) provide anchorage for SARS-CoV-2 binding, thus implicating that ACE and ACE2 might contribute to the variability in infection severity. This study aimed to elucidate predisposing factors influencing the disease course among people infected by SARS-CoV-2, focusing on angiotensin-converting enzyme (ACE) and ACE2 polymorphisms. Notably, despite similar demographics and comorbidities, COVID-19 patients exhibit substantial differences in prognosis. Genetic polymorphisms in ACE and ACE2 have been implicated in disease progression, prompting our investigation into their role in COVID-19 evolution. Using next-generation sequencing (NGS), we analyzed ACE and ACE2 genes in a sample group comprising six subjects infected by SARS-CoV-2. Our findings revealed a correlation between specific polymorphisms and COVID-19 outcomes. Specifically, ACE and ACE2 intronic deletions were observed in all deceased patients, suggesting a potential association with mortality. These results highlight the significance of genetic factors in shaping the clinical course of COVID-19, emphasizing the importance of further research into the impact of genetic variations on COVID-19 severity.
Designating Airsheds in India for Urban and Regional Air Quality Management
Authors: Guttikunda Sarath K
Published: May 2024

Air pollution knows no boundaries, which means for a city or a region to attain clean air standards, must not only look at the emission sources within its own administrative boundary, but also at sources in the immediate vicinity and those originating from long-range transport. And there is a limit to how much area can be explored to evaluate, govern, and manage as designated airsheds for cities and larger regions. This paper discusses the need from an official airshed framework for India’s air quality management, urban airsheds designated for India’s 131 non-attainment cities under the national clean air programme, and proposes climatically and geographically appropriate regional airsheds to support long-term planning. Between 28 states, eight union territories, 36 meteorological sub-regional divisions, and six regional meteorological departments, establishing the proposed 15 regional airsheds for integrated and collaborative air quality management across India is a unique opportunity.
Exploring the Potential of Using High-Performance Rubberized Concrete in Column Jacketing
Authors: Habib Ahed , Yildirim Umut , Eren Ozgur
Published: May 2024

In recent years, extensive research has focused on investigating rubberized concrete as a structural material due to its enhanced properties, including increased ductility, improved energy dissipation, and higher damping ratios. Additionally, rubberized concrete contributes to sustainable development by recycling non-biodegradable waste and reducing the use of natural aggregates in concrete mixtures. However, its performance in retrofitting existing structures remains unclear and requires thorough investigation before it can be widely implemented in construction activities. The main objective of this research is to evaluate the seismic performance of reinforced concrete buildings strengthened with rubberized concrete jackets under severe earthquake excitations. To achieve this, laboratory tests were conducted to assess the properties of high-performance, self-compacting rubberized concrete mixes with various rubber content levels. Additionally, finite element models of reinforced concrete retrofitted with these mixes were analyzed using nonlinear response history analysis to compare their performance against control models. The results of this experimental work indicate a significant reduction in the mechanical properties of rubberized concrete. However, there is a considerable improvement in the damping ratio, which enhances the energy dissipation capacity of the structures. This improvement contributes to an increase in damping energy and a reduction in hysteretic energy, suggesting that rubberized concrete jackets can enhance the seismic resilience of reinforced concrete buildings.
SARS-CoV-2 Antibody Seroprevalence in Gabon: Findings from the Nationwide Household Serosurvey in a Sub-Saharan Africa Country
Authors: Zoa-Assoumou Samira , Essone Paulin , Adamou Rafiou , Oyegue-Liabagui Sandrine Lydie , Mveang Nzoghe Amandine , Roméo  Adegbite Bayodé , Mintsa Ndong Armel , Alame-Emane Amel Kévin , Mbomo Steeve Hermes , Ndanga Tiagni Joseph , Mboyis Kandem Herve , More Ayong , Magossou Mbadinga Marien Juliet Verraldy , Mikelet Boussoukou Ismael Pierrick , Maloupazoa Siawaya Anicet Christel , Atsame Juliette , Matsingang Aliette Olivia , Bikangui Rodrigue , Ndjonkou Siawaya Raphael Edward , Mouangala Ulrick Leger Davy , Angoune-Ndong Davy-Christ , Mouhamed Mohod Arnaud , Malandou Anais , Nziengui-Nziengui Francis , Ndjoyi-Mbiguino Angelique , Mounioko Franck , Kouna Lady Charlène , Mbani Mpega Ntigui Cherone Nancy , Biteghe Bi Esoone Jean Claude , Armel Brice AMALET AKAGHA , Mengue Me Ngou-Milama Krystina , Imboumy-Limoukou Roméo Karl , Bagayoko Magaran Monzon , Aboubacar Inoua , Lekana-Douki Jean-Bernard , Djoba Siawaya Joel Fleury , Adegnika Ayola Akim , Ngoungou Edgard-Brice
Published: May 2024

Seroconversion surveys of anti-SARS-CoV-2 antibodies provide accurate estimates of the SARS-CoV-2 infection. This nationwide population-based cross-sectional serosurvey aimed to evaluate the prevalence of SARS-CoV-2 antibodies among residents in Gabon and compare the estimated cumulative number of COVID-19 cases with the officially registered number of laboratory-confirmed cases up to December 2021. Households in each province were randomly selected. Twenty-eight localities including 16 urban and 12 rural, were randomly selected to participate in the study. Whole blood samples were collected in dry tubes from all study participants around the country within 15 days. Serum samples were used to measure the total Immunoglobulin antibodies. Overall, data of 1672 households were analyzed. Out of the 3659 participants, 3175 were found positive for SARS-CoV-2 antibodies, resulting in a crude seroprevalence of 86.77%. Stratification of study participants by age group has shown highest seroprevalences in 20–29 and 40-49 age groups with 91.78% (95% CI:89.5–93.6) and 91.42% (95% CI:88.7–93.5), respectively. Nyanga province had the lowest prevalence (72,8%), and Estuaire and Ogoué-Lolo provinces had the highest prevalence (90 and 92%, respectively). Our results suggest a high transmission rate in the Gabonese population, 21 months after the first SARS-CoV-2 case in the country. This high seroprevalence estimate could indicate that the applied infection control measures may not have been adequately implemented or appropriately adhered to by the population.
Macrophages as a Source and Target of GDF-15
Authors: Bermudez Lina Susana Silva , Klüter Harald , Kzhyshkowska Julia
Published: May 2024

Macrophages as a source and target of GDF-15
The Dynamics of Soluble Sugars in Arabica Coffee Cherry Fruits
Authors: Baptistella João Leonardo Corte , Assoni Giovani , da Silva Marcio Souza , Mazzafera Paulo
Published: May 2024

The maturation process of Arabica coffee fruits is influenced by plant endogenous and external factors. The maturation stage of the fruits affects the bean's chemical composition, which is related to coffee beverage quality. During fruit maturation, the colour of the peel changes from green to red (cherry), which indicates the harvest time and supposedly that the fruits have high quality. However, many tones of red may define fruit maturity. This work aimed to study the dynamics of soluble sugar accumulation related to fruit redness in coffee fruit tissues. We classified the ripe fruits into six ripeness classes based on the intensity of the red colour of the epicarp using a colourimeter. Total soluble sugar, sucrose and starch were analyzed in the coat (exocarp+mesocarp), coat juice (obtained by squeezing the coat), and beans. We showed that endosperm sugar dynamics do not follow changes in the coat, indicating a separate control of sugar accumulation, mainly related to sucrose, an essential component of coffee quality. Our data show that there is no transfer of sucrose and reducing sugars from the red coat to the bean.
Transforming Aquaculture Through Vaccination: A Review on Recent Developments and Milestones
Authors: Tammas Iosif , Bitchava Konstantina , Gelasakis Athanasios I.
Published: May 2024

Aquaculture has rapidly emerged as one of the fastest growing industries, expanding both on global and on national fronts. With the ever-increasing demand for high biological value protein, the aquaculture industry has established itself as one of the most efficient forms of animal production, proving to be a vital component of global food production, by supplying nearly 50% of the planet’s seafood. As in classic animal production, the prevention of diseases constitutes an enduring challenge associated with severe economic and environmental repercussions. Nevertheless, remarkable strides in the development of aquaculture vaccines have been recently witnessed, offering sustainable solutions to persistent health-related issues challenging resilient aquaculture production. These advancements are characterized by breakthroughs in increased species-specific precision, improved vaccine delivery systems, and innovations in vaccine development, following the recent advent of nanotechnology, biotechnology, and artificial intelligence in the -omics era. The objective of this paper was to assess recent developments and milestones revolving around aquaculture vaccinology and provide an updated overview of strengths, weaknesses, opportunities, and threats of the sector, by incorporating and comparatively discussing various diffuse advances that span across a wide range of topics, including emerging vaccine technologies, innovative delivery methods, insights on novel adjuvants, and parasite vaccine development for the aquaculture sector.
Finding the Correlation between Transport Infrastructure and the Fatal Accident Rate of Cyclists—An International Perspective
Authors: Gogola Marian , Senko Šimon , Mikusova Miroslava
Published: May 2024

Bicycle transport stands at the forefront of sustainable mobility initiatives, a cornerstone of European Union policy. While support for cycling is crucial, its advancement hinges upon the presence of high-quality, secure infrastructure for cyclists. Safety emerges as a paramount concern, influencing the viability of cycling as a mode of transportation, yet its perception varies among user demographics. In light of this, this article endeavors to examine and contrast cycling infrastructure across various European nations, alongside analyzing statistics pertaining to fatal traffic accidents involving cyclists. The findings underscore a substantial correlation between the quality of cycling infrastructure and the incidence of accidents. This correlation underscores the pressing need for robust infrastructure development and safety measures to bolster cycling as a safe and viable transportation option. By understanding the intricate interplay between infrastructure quality and safety outcomes, policymakers can better prioritize resources and enact measures to foster safer cycling environments, thus furthering the objectives of sustainable mobility on a continental scale.
Stability of Single Channel Homing Slow-Rolling Missile
Authors: Chelaru Teodor-Viorel , Constantinescu Cristian Emil , Pană Valentin , Ene Costin , Chelaru Adrian
Published: May 2024

Starting from the model of a slow-rolling missile with six degrees of freedom (6 DOF) in the body frame, a 6 DOF model in the Resal frame is obtained, which is used to linearize the coupled commanded motion. Based on the linearized model, we obtain the structural scheme of the commanded object and define the quality parameters. The obtained parameters have a complex representation (with real and imaginary parts) due to the coupling between longitudinal channels. Then, the kinematic guidance equations, the seeker equations and the actuator specific to the slow-rolling single-channel missile are defined using a switching function. The guidance kinematic equations, the seeker equations and the actuator model are linearized in the Resal frame, and the structural diagram of the homing missile is constructed. Starting from this, the characteristic polynomial having complex coefficients is determined and then analyzed with the Frank-Wall stability criterion. Based on the analysis, a stability range is determined for the navigation constant and a minimum and possibly a maximum limit for the time to hit the target is obtained. The stability range defined for the navigation constant on the linear model is finally validated on the nonlinear model in the body frame.
Prevalence and Trend of Drug Use among Adolescents in Mississippi and the United States: Youth Risk Behavior Surveillance System (YRBSS) 2001–2021
Authors: Zhang Zhen , Mitra Amal K. , Schroeder Julie A , Zhang Lei
Published: May 2024

Mississippi youth are demographically unique compared to that of the nation. The purpose of this study was to determine the trend of drug use among adolescents of the United States and Mississippi, and to estimate the differences of drug use prevalence as a whole, and by gender and by race. National and Mississippi YRBSS data from 2001 to 2021 were obtained for analysis. Summary statistics, prevalence ratio, and survey Chi-squared tests of independence statistics were generated for the comparison for all students, and by gender and race separately. Trend analysis was conducted using logistic regression combined with joinpoint regression. Six survey questions being studied were: have you ever used marijuana, inhalant, heroin, methamphetamines, injected drugs, and were you offered, sold, or given an illegal drug on school property during the last 12 months. Survey packages in R were used to account for the complex sampling design of YRBSS data. On the national level, all six drug related risk behaviors being studied showed significant decrease from 2001 to 2021. In Mississippi however, only “ever used marijuana” showed a trend of decrease, while three remain unchanged, and two increased. 2021 YRBSS data shows that Mississippi adolescents exhibited significantly higher prevalence of drug use, and are more likely to be offered, sold or given an illegal drug on school property. Our study suggests an urgent need for drug use intervention among Mississippi adolescents. More concerted actions at the community, school and government level are needed for reducing youth drug use and controlling the drug traffic on school property.
Crude Extracts from Lippia adoensis (Hochst.) Inhibit the Growth of Plasmodium, Leishmania and Trypanosoma Parasites
Authors: Madiesse Kemgne Eugenie Aimée , Tchatat Tali Mariscal Brice , Dize Darline , Njanpa Ngansop Cyrille Armel , Pone Kamdem Boniface , Fekam Boyom Fabrice
Published: May 2024

The serendipitous discovery of antiparasitic drugs, such as quinine and artemisinin from plant origin reveals that the search for new chemical pharmacophores from medicinal plants is valuable. The present study sought to explore the antiplasmodial, antileishmanial, and antitrypanosomal activities of extracts from Lippia adoensis. Crude extracts of L. adoensis leaves and twigs, which were obtained by extraction using 70% ethanol in water, were assayed for antiplasmodial activity against P. falciparum 3D7 and Dd2 through the SYBR green I-based fluorescence assay; and for antileishmanial, antitrypanosomal, and cytotoxic effects on Leishmania donovani, Trypanosoma brucei brucei, and Vero cells, respectively, using the resazurin colorimetric assays. The phytochemical analysis of the extracts was performed using a liquid chromatography-mass spectrometry (LC-MS) feature-based detection and molecular networking flow on Global Natural Product Social (GNPS). As a result, the crude extracts from L. adoensis inhibited growth of P. falciparum (3D7 and Dd2) (IC50s; (3D7): 10.008 and 97.467 μg/mL; (Dd2): 29.48 and 26.96 μg/mL), L. Donovani (IC50s: 22.879-10.522 μg/mL), and T. brucei brucei (IC50s: 2.3085-55.06 μg/mL). The extracts were found to be non-cytotoxic to Vero cells, thus yielding median cytotoxic concentrations (CC50s) above 100 μg/mL. The LC-MS tandem molecular networking flow predicted that the extracts contain valsafungin A and bacillamidin on the first cluster, and fatty acids, ketone and aldehyde derivatives on the second cluster. Overall, the present study demonstrated the antiparasitic effects of L. adoensis extracts, thus justifying the use of this plant in the traditional treatment of fever and malaria conditions. Nevertheless, detailed metabolomic studies and antiparasitic mechanisms of action of the extracts are expected to unveil the potential antiparasitic hit compounds.
Development of Hospital Management Information System Research
Authors: ABUEL AFIEH AHMAD
Published: May 2024

Health care operations in many hospitals are experiencing increasing demand which is however hindered by the limited resources available. The imbalance between the demand and service provision capacity within the hospitals have resulted in long waiting times for service delivery due to overcrowding, high costs of treatment as well as low levels of patient’s satisfaction. The above problems are attributed to the development of hospital management information system. This dissertation is focused on investigating some of the causes of the increased cost and time consumption as well as low levels of patient’s satisfaction in the application of hospital management information system. The study used comparative design to make a comparison of the respondents from two different hospital facilities where 400 health workers were drawn for research. The questionnaire was used as a survey tool for the study that involved both qualitative and quantitative analysis. The results of the study indicate various playing factors that arise due to the development of the hospital management information system. These factors include the large functionality of the system, the need for training of the end users, the increasing ageing population, and delays. The identified factors play a significant role in the way the information system impacts the time taken, the cost involved, and patient satisfaction. Keywords: health, hospital, doctors, technology, information system, time, and cost.
MDH2 Promotes Hepatocellular Carcinoma Growth through Ferroptosis Evasion via Stabilizing GPX4
Authors: Bian Xueli , Yu Wenjia , Li Yingping , Gao Chengchang , Dai Bolei , Yang Haoying , Han Linfen
Published: May 2024

The crosstalk between tumor progression and ferroptosis is largely unknown. Here, we identify malate dehydrogenase 2 (MDH2) as a key regulator of ferroptosis. MDH2 de-ficiency inhibits hepatocellular carcinoma (HCC) cell growth and promotes sensitivity of HCC cells to RSL3-induced ferroptosis. MDH2 knockdown enhances RSL3-induced intracellular reactive oxygen species (ROS), free iron ions and lipid peroxides levels, leading to HCC ferroptotic cell death which is rescued by Ferrostatin-1 and iron chelator Deferiprone. Importantly, inhibition of HCC cell growth caused by MDH2 deficiency is partially rescued by ferroptosis blockade. Mechanistically, MDH2 resists RSL3-induced ferroptosis sensitivity by dependence on GPX4, which is stabilized by MDH2 in HCC. The protein expression of MDH2 and GPX4 is positively correlated with each other in HCC cell lines. Furthermore, The Cancer Genome Atlas (TCGA) database shows that MDH2 and GPX4 are highly expressed in HCC samples, their expression is positively correlated with HCC stages, and GPX4 expression is associated with poor prognosis of HCC patients. These findings reveal a critical mechanism by which HCC evades fer-roptosis via MDH2-mediated stabilization of GPX4 to promote tumor progression and underscore the potential of MDH2 inhibition in combination with ferroptosis inducers for the treatment of HCC.
Study on the Safety Characteristics of Different Types of Pepper (Capsicum L.)
Authors: Kosár László , Szabová Zuzana , Kuracina Richard , Spitzer Stefan H , Mynarz Miroslav , Filipi Bohdan
Published: May 2024

The research was aimed at comparing the fire characteristics of different types of pepper in the context of designing explosion prevention. The following characteristics were studied: explosion pressure pmax and Kst at selected concentrations, ignition temperature of the deposited dust layer from the hot surface and minimum initiation energy. The comparison of the chemical properties of the used types of pepper was performed using TG/DSC. Results of the measurements suggest that different types of peppers exhibit different explosion characteristics. Each of the samples reached the maximum value of the explosion pressure, and their rate of pressure rise increased at different concentrations. The volume of the explosion chamber used also influenced the explosion characteristics. It is a consequence of the fact that the explosion characteristics strongly depend on the mechanism of action of a particular igniter. The minimum effect on the safety characteristics was observed when measuring the minimum initiation energy and the minimum ignition temperature of dust layer from the hot surface. The results of the measurements suggest that different types of peppers exhibit different explosion characteristics. This information should then be considered in explosion prevention.
MicroRNA Expression in Patients with Coronary Artery Disease and Hypertension – a Systematic Review
Authors: Kondracki Bartosz , Kłoda Mateusz , Jusiak-Kłoda Anna , Kondracka Adrianna , Wacinski Jakub , Waciński Piotr
Published: May 2024

Coronary artery disease (CAD) and hypertension significantly contribute to cardiovascular morbidity and mortality. MicroRNAs (miRNAs) have recently emerged as promising biomarkers and therapeutic targets for these conditions. This systematic review conducts a thorough analysis of the literature, with a specific focus on investigating miRNA expression patterns in patients with CAD and hypertension. The review encompasses an unspecified number of eligible studies that employed a variety of patient demographics and research methodologies, resulting in diverse miRNA expression profiles. This review highlights the complex involvement of miRNAs in CAD and hypertension and the potential for advances in diagnostic and therapeutic strategies. Future research endeavours are imperative to validate these findings and elucidate the precise roles of miRNAs in disease progression, offering promising avenues for innovative diagnostic tools and targeted interventions.
Flexible Asymmetric Supercapacitors Constructed by Reduced Graphene Oxide/MoO3 and MnO2 Electrochemically Deposited on Carbon Cloth
Authors: Li Sha , Li Zhi ying
Published: May 2024

A flexible asymmetric supercapacitor (ASCs) is successfully developed by using the composite of MoO3 and graphene oxide (GO) electrochemically deposited on carbon cloth (CC) (MoO3/rGO/CC) as the negative electrode, the MnO2 deposited on CC (MnO2/CC) as the positive electrode and Na2SO4/polyvinyl alcohol (PVA) as gel electrolyte. The results show that the introduction of GO layer can remarkably increase the specific capacitance of MoO3 from 282.7 F g-1 to 341.0 F g-1. Furthermore, the combination of such good electrode materials and a neutral gel electrolyte renders the fabrication of high-performance ASC with a large operating potential difference of 1.6 V in 0.5 mol L-1 Na2SO4 solution of water. Furthermore, the ASCs exhibit excellent cycle ability and the capacitance can maintain 87 % of its initial value after 6000 cycles. The fact that a light-emitting diode can be lighted up by the ASCs indicates the device’s potential applications as energy storage devices. The encouraging results demonstrate a promising application of the composite of MoO3 and GO in energy storage devices.
Integration of PV Systems in the Urban Environment—A Review
Authors: Rodrigues André , Palmero-Marrero Ana I. , Oliveira Armando C.
Published: May 2024

Building integrated photovoltaics (BIPV) consists of PV panels that are integrated into the building as part of the construction. This technology has advantages such as the production of electricity without necessary additional land area. This paper provides a literature review about the recent developments in urban building energy modelling, including tools and methods, and the effect of PV systems on building outdoor and indoor environments. It is also intended to provide a critical analysis on how PV systems affect the urban environment, both from an energy and a comfort point of view. The urban heat island development is introduced and related with the existence of PV systems. It is concluded that data acquisition is still a weakness in urban building energy modelling, especially in what concerns non-geometric data, which leads to a major source of errors. The availability of data is a challenge because frequently they are not accessible, due to privacy, high-cost or other reasons. Also, methodologies to develop precise archetypes for creating urban building energy models are lacking.
Long-Term Prognostic Impact of Insulin- and Non-insulin Treated Diabetes Mellitus in Patients With a Reduced Left Ventricular Ejection Fraction Following ST-Elevation Myocardial Infarction
Authors: Savić Lidija , Mrdovic Igor , Asanin MIlika , Stankovic Sanja , Lasica Ratko , Krljanac Gordana
Published: May 2024

Background/aim: Insulin- and non-insulin treated diabetes (ITDM and NITDM) may have different prognostic impact in patients with ST-elevation myocardial infarction (STEMI) and /or heart failure. The aims of this study were to analyze the impact of ITDM and NTIDM on the incidence of all-cause mortality and major adverse cardiovascular events (MACE- cardiovascular death, non-fatal infarction, non-fatal stroke and tagert vessel revascularization) in the eight-year follow-up of STEMI patients with a reduced ejection fraction (EF).
Method: we analysed 2,230 STEMI patients with EF
Developing Standard BIM Execution Plans for Complex Construction Projects
Authors: Abdelalim Ahmed Mohammed , Shawky Kamal , A.AL Nasser AlJawharah , Shibeika Amna , Sherif Alaa
Published: May 2024

This study focuses on the difficulties of standardizing Building Information Modeling (BIM) Execution Plans (BEPs) in the Architecture Engineering Construction and Operations (AECO) sector. The main objective is to improve digital transformation by implementing more efficient methodologies. The task involves analyzing 36 BEP documents from different international organizations to identify similarities and differences in terms of content structure operational methods and project characteristics. The research highlights the necessity of implementing a uniform method to enhance collaboration and information sharing in BIM projects. The documents contain key elements such as project information goals roles collaboration procedures model structure and quality control. The paper presents a comprehensive framework for BEPs with the goal of resolving the discrepancies observed in existing methods that impede the efficiency of project delivery. This study utilizes scientometric analysis to examine literature published between 2020 and 2023. The aim is to track the progress of BEP standards identify key research topics and determine influential works in the field. The findings support the implementation of standardized guidelines to reduce inefficiencies and improve the effectiveness of Building Information Modeling (BIM) in large-scale construction projects.
Iron Oxide Nanoparticles as Photothermal Agents: Optimal Parameters for Photoconversion Efficiency and Ability for Synergistic Cancer Treatment
Authors: Grancharova Tsenka , Zagorchev Plamen , Pilicheva Bissera
Published: May 2024

Photothermal therapy (PTT) can overcome cancer treatment resistance by enhancing cell membrane permeability, facilitating drug accumulation, and promoting drug release within the tumor tissue. Iron oxide nanoparticles (IONPs) have emerged as effective agents for PTT due to their unique properties and biocompatibility. Approved for the treatment of anemia, as MRI contrast agents, and as magnetic hyperthermia mediators, IONPs also offer excellent light-to-heat conversion and can be manipulated using external magnetic field for targeted accumulation in specific tissues. Optimizing parameters such as laser wavelength, power density, shape, size, iron oxidation state, functionalization, and concentration is crucial for IONPs effectiveness. In addition to PTT, IONPs enhance other cancer treatment modalities. They improve tumor oxygenation enhancing the efficacy of radiotherapy and photodynamic therapy. IONPs can also trigger ferroptosis, a programmed cell death pathway mediated by iron-dependent lipid peroxidation. Their magneto-mechanical effect can exert mechanical force on cancer cells to destroy tumors, minimizing damage to healthy tissues. This review outlines strategies for managing photothermal performance and PTT efficiency with iron oxide nanoparticles, as well as synergies with other cancer therapies.
Identification and Spatiotemporal Expression of a Putative New GABA Receptor Subunit in the Human Body Louse Pediculus humanus humanus
Authors: HASHIM Omar , Toubate Bertine , Charvet Claude L. , Ahmed Aimun A. E. , Neveu Cédric , Dimier-Poisson Isabelle , Debierre-Grockiego Françoise , Dupuy Catherine
Published: May 2024

Human louse (Pediculus humanus) is an obligatory blood feeding ectoparasite with two ecotypes: human body louse (Pediculus humanus humanus), a competent vector of several bacterial pathogens and the human head louse (Pediculus humanus capitis) responsible for pediculosis and affecting millions of people around the globe.
GABA (γ-aminobutyic acid) receptors, members of the cys-loop ligand gated ion channels superfamily, are among the main pharmacological targets for insecticides. In insects, four subunits of GABA receptors: resistant to dieldrin (RDL), glycin like receptor of drosophila (GRD), ligand gated chloride channel homologue3 (LCCH3), and 8916 are well described and form distinct phylogenetic clades revealing orthologous relationships. Our previous studies in human body louse confirmed that subunits Phh-RDL, Phh-GRD and Phh-LCCH3 are well clustered in their corresponding clades. In the present work, we cloned and characterized a putative new GABA receptor subunit in human body louse that we named HoCas for Homologous to Cys-loop alpha like subunit. Extending our analysis to arthropods, HoCas was found to be conserved and clustered in a new (fifth) phylogenetic clade. Interestingly, the gene encoding this subunit is ancestral and has been lost in some insect orders. Compared to the other studied GABA receptor subunits, HoCas exhibited a relatively higher expression level in all development stages and in different tissues of human body louse. These findings improved our understanding of the complex nature of GABA receptors in Pediculus humanus and more generally in arthropods.
Assessment of Particulate Organic Carbon in the Mediterranean Sea Based on Dual-Optimization Random Forest
Authors: Li Chao , Wu Huisheng , Yang Chaojun , Cui Long , Ma Ziyue , Wang Lejie
Published: May 2024

Particulate organic carbon (POC) is a pivotal component within the marine carbon cycle, actively involved in diverse biogeochemical processes. This study focuses on Mediterranean as the research region, selecting the most influential factors from 47 potential ones influencing surface POC. Using geographic detector for factor identification, ten primary influencers were identified. Preliminarily optimized random forest (BRF), backpropagation neural network, adaptive boosting, and extreme gradient boosting were utilized to construct POC assessment models. Notably BRF exhibited superior performance in estimating the sea surface POC. Further optimization of RF using the tuneRanger R package resulted in R² of 0.868, mean squared error of 1.119 (mg/m³) ², and mean absolute error of 1.041 (mg/m³). Surface POC concentrations in the Mediterranean for May and June 2017 were estimated. Spatial distribution analysis unveiled higher concentrations in the west, lower in the east, higher in the north, lower in the south, with higher levels near the coast and lower far from the coast. Additionally, the study deliberated on the impact of human activities on surface POC in the Mediterranean. This research contributes a high-precision method for satellite retrieval of surface POC concentrations in the Mediterranean, thereby enriching the understanding of POC dynamics in the area.
Antiproliferative Effect of 7- Ketositosterol in Breast and Liver Cancer Cells: Possible Impact of Ceramide, ERK and NF-kB Signaling Pathways
Authors: Barut Zerrin , Aslan Mutay , Çırçırlı Bürke , Çeker Tuğçe , Yılmaz Çağatay
Published: May 2024

Background: This study aimed to examine the effect of 7-Ketositosterol (7-KSS), on sphingomyelin/ceramide metabolites and apoptosis in human breast MCF-7 and human liver HepG2 cancer cells. Methods: Anti-proliferative effects of 7-KSS treatment were assessed at different concentrations and periods. Cell viability was assessed through MTT analysis, whereas the levels of sphingosine-1-phosphate (S1P), sphingomyelins (SMs), and ceramides (CERs) were measured using LC-MS/MS. Phosphorylated 44/42 ERK1/2 and NF-kB p65 (Ser536) protein levels were measured by western blot analysis and immunofluorescence staining. Apoptosis was evaluated by TUNEL staining and flow cytometric assessment of annexin-V and propidium iodide (PI) labeling. Results: Treatment with 7-KSS significantly decreased cell survival, S1P, p-44/42 ERK1/2, and p-NF-κBp65 protein levels in cancer cells compared to controls. A substantial rise was detected in intracellular amounts of C16-C24 CERs and apoptosis in cancer cells incubated with 7-KSS. Conclusions: 7-KSS stimulated ceramide accumulation and apoptosis while decreasing cell proliferation via downregulating S1P, p-44/42 ERK1/2 and p-NF-κBp65 protein levels.
Parecoxib and 5-Fluorouracil Synergistic Inhibition of Metastasis of Colorectal Cancer Cells by Targeting Akt/NF-κB and EMT Pathways
Authors: Chang Wan-Ling , Peng Jyun-Yu , Hong Chain-Lang , Li Pei-Ching , Lu Fung-Jou , Chen Ching-Hsein
Published: May 2024

Colorectal cancer is one of the most common causes of cancer mortality worldwide, and innovative drugs for the treatment of colorectal cancer are continually being revealed. 5-Fluorouracil (5-FU) is a common clinical chemotherapeutic drug. Acquired resistance to 5-FU is a clinical challenge in colorectal cancer. Parecoxib is a selective COX-2-specific inhibitor, which has been demonstrated to inhibit metastasis in colorectal cancers in our previous study. This study aimed to investigate the synergistic antimetastatic activities of parecoxib to 5-FU in human colorectal cancer cells and determine the underlying mechanism. parecoxib and 5-FU synergistically suppressed metastasis in colorectal cancer cells. Treatment with the parecoxib /5-FU combination induced an increase in E-cadherin and decrease in β-catenin. The parecoxib/5-FU combination could inhibit MMP-9 and MMP-2 expression and MMP-9 activity, and the NF-κB pathway might be suppressed as well. Mechanistic analysis denoted that the parecoxib/5-FU combination hindered the essential molecules of the PI3K/Akt route to obstruct metastatic colorectal cancer. Furthermore, the parecoxib/5-FU combination could inhibit reactive oxygen species. Our work showed the antimetastatic capacity of the parecoxib/5-FU combination for colorectal cancers via targeting the PI3K/Akt /NF-κB pathway.
Analysis, Design, and Experimental Validation of a High-Isolation, LowCross-Polarization Antenna Array Demonstrator for Software-Defined-Radar Applications
Authors: Ricciardella Nicholas , Fuscaldo Walter , Mattei Tito , Fiorello Anna Maria , Infante Leopoldo , Galli Alessandro
Published: May 2024

In a software-defined radar (SDR) system, most of the signal processing usually implemented
in hardware is implemented by software, thus allowing for higher flexibility and modularity compared to
conventional radar systems. However, the majority of SDR demonstrators and proofs-of-concept reported in the open literature so far have been based on simple antenna systems. As a result, the full potentialities of an SDR approach have not been completely exploited yet. In this work, we propose a flexilbe antenna module to be integrated into an active electronically scanning array (AESA) with controlled sidelobe level over a wide angular range, exhibiting polarization reconfigurability with low cross-polarization level and high isolation. For this purpose, analytical and numerically efficient techniques for the synthesis of the aperture distribution and the correct evaluation of the radiating features (e.g., beamwidth, pointing angle, sidelobe levels, etc.) are presented in order to grant a real-time control of the digital beamforming network. A sub-array module demonstrator is fabricated and measured to corroborate the concept.
Challenges and Prospects of International Law in the 21st Century
Authors: Ali Ahmad Mustafa , Hassan Salam Abdullah , Mousa Kawar Mohammed
Published: May 2024

International law faces numerous challenges in the 21st century, ranging from the traditional issues of sovereignty to emerging threats like cyber warfare and climate change. This article explores the evolving landscape of international law, discussing both the challenges it faces and the prospects for its future. By examining the role of international organizations, the impact of technological advancements, and the growing influence of non-state actors, this article provides a comprehensive overview of the current state of international law and offers insights into how it can adapt to meet the demands of an increasingly interconnected world.