bluuebunny/crossref_metadata_2025 huggingface dataset:
Mohand homotopy transform scheme for the numerical solution of fractional Kundu–Eckhaus and coupled fractional Massive Thirring equations
Authors: Luo Xiankang , Nadeem Muhammad
Published: March 2023

In this paper, Mohand homotopy transform scheme is introduced to obtain the numerical solution of fractional Kundu–Eckhaus and coupled fractional Massive Thirring equations. The massive Thirring model consists of a system of two nonlinear complex differential equations, and it plays a dynamic role in quantum field theory. We combine Mohand transform with homotopy perturbation scheme and show the results in the form of easy convergence. The accuracy of the scheme is considerably increased by deriving numerical results in the form of a quick converge series. Some graphical plot distributions are presented to show that the present approach is very simple and straightforward.
Altered sialin mRNA gene expression in type 2 diabetic male Wistar rats: implications for nitric oxide deficiency
Authors: Yousefzadeh Nasibeh , Jeddi Sajad , Zarkesh Maryam , Kashfi Khosrow , Ghasemi Asghar
Published: March 2023

Nitrate therapy has been suggested to boost nitric oxide (NO) levels in type 2 diabetes (T2D); however, little is known about nitrate transport across the membranes. This study aimed to assess changes in the mRNA expression of sialin, as a nitrate transporter, in the main tissues of rats with T2D. Rats were divided into two groups (n = 6/group): Control and T2D. A high-fat diet combined with a low dose of streptozotocin (STZ, 30 mg/kg) was used to induce T2D. At month 6, samples from the main tissues of rats were used to measure the mRNA expression of sialin and levels of NO metabolites. Rats with T2D had lower nitrate levels in the soleus muscle (66%), lung (48%), kidney (43%), aorta (30%), adrenal gland (58%), epididymal adipose tissue (eAT) (61%), and heart (37%) and had lower nitrite levels in the pancreas (47%), kidney (42%), aorta (33%), liver (28%), eAT (34%), and heart (32%). The order of sialin gene expression in control rats was: soleus muscle > kidney > pancreas > lung > liver > adrenal gland > brain > eAT > intestine > stomach > aorta > heart. Compared to controls, rats with T2D had higher sialin mRNA expressions in the stomach (2.1), eAT (2.0), adrenal gland (1.7), liver (8.9), and soleus muscle (3.4), and lower sialin expression in the intestine (0.56), pancreas (0.42), and kidney (0.44), all P values < 0.05. These findings indicate altered sialin mRNA expression in the main tissues of male T2D rats and may have implications for future NO-based treatment of T2D.
Slope monitoring optimization considering three-dimensional deformation and failure characteristics using the strength reduction method: A case study
Authors: Wang Jianxiu , Li HubBoqiang , Jiang Yunhua , Tian Puzhuo , Cao Ansheng , Long Yanxia , Liu Xiaotian , Si Pengfei
Published: March 2023

The potential deformation and failure of a slope with typical 3D shapes involve 3D characteristics, such that these factors cannot be simulated using 2D methods. If 3D characteristics are not considered in expressway slope monitoring, an excessive number of monitoring points may be arranged in the stable/safe part, whereas insufficient monitoring points may be arranged in the unstable/dangerous part. In this study, the 3D deformation and failure characteristics of the Lijiazhai slope of the Shicheng–Ji'an Expressway in Jiangxi Province, China were analyzed by 3D numerical simulations using the strength reduction method. The potential 3D slope surface displacement trends, initial position of failure, and maximum depth of potential slip surface were simulated and discussed. The deformation of Slope A was generally small. The slope ranging from the third platform to the slope top was located in Region I, where the deformation was approximately equal to zero. The deformation of Slope B was located in Region V, where the displacement generally was larger than 2 cm in the range from the first–third platforms to the slope top, and the deformation of the trailing edge exceeded 5 cm. The surface displacement monitoring points should be arranged in Region V. Monitoring was then optimized considering the 3D characteristics of the deformation and failure of a slope. Accordingly, surface and deep displacement monitoring networks were effectively arranged in the unstable/dangerous part of the slope. Results may be used as references for similar projects.
Prediction of prognosis in patients with severe COVID-19 pneumonia using CT score by emergency physicians: a single-center retrospective study
Authors: Oi Yasufumi , Ogawa Fumihiro , Yamashiro Tsuneo , Matsushita Shoichiro , Oguri Ayako , Utada Shusuke , Misawa Naho , Honzawa Hiroshi , Abe Takeru , Takeuchi Ichiro
Published: March 2023

We aimed to develop a method to determine the CT score that can be easily obtained from CT images and examine its prognostic value for severe COVID pneumonia. Patients with COVID pneumonia who required ventilatory management by intubation were included. CT score was based on anatomical information in axial CT images and were divided into three sections of height from the apex to the bottom. The extent of pneumonia in each section was rated from 0 to 5 and summed. The primary outcome was the prediction of patients who died or were managed on extracorporeal membrane oxygenation (ECMO) based on the CT score at admission. Of the 71 patients included, 12 (16.9%) died or required ECMO management, and the CT score predicted death or ECMO management with ROC of 0.718 (0.561–0.875). The death or ECMO versus survival group (median [quartiles]) had a CT score of 17.75 (14.75–20) versus 13 (11–16.5), p = 0.017. In conclusion, a higher score on our generated CT score could predict the likelihood of death or ECMO management. A CT score at the time of admission allows for early preparation and transfer to a hospital that can manage patients who may need ECMO.
Patient-centric synthetic data generation, no reason to risk re-identification in biomedical data analysis
Authors: Guillaudeux Morgan , Rousseau Olivia , Petot Julien , Bennis Zineb , Dein Charles-Axel , Goronflot Thomas , Vince Nicolas , Limou Sophie , Karakachoff Matilde , Wargny Matthieu , Gourraud Pierre-Antoine
Published: March 2023

While nearly all computational methods operate on pseudonymized personal data, re-identification remains a risk. With personal health data, this re-identification risk may be considered a double-crossing of patients’ trust. Herein, we present a new method to generate synthetic data of individual granularity while holding on to patients’ privacy. Developed for sensitive biomedical data, the method is patient-centric as it uses a local model to generate random new synthetic data, called an “avatar data”, for each initial sensitive individual. This method, compared with 2 other synthetic data generation techniques (Synthpop, CT-GAN), is applied to real health data with a clinical trial and a cancer observational study to evaluate the protection it provides while retaining the original statistical information. Compared to Synthpop and CT-GAN, the Avatar method shows a similar level of signal maintenance while allowing to compute additional privacy metrics. In the light of distance-based privacy metrics, each individual produces an avatar simulation that is on average indistinguishable from 12 other generated avatar simulations for the clinical trial and 24 for the observational study. Data transformation using the Avatar method both preserves, the evaluation of the treatment’s effectiveness with similar hazard ratios for the clinical trial (original HR = 0.49 [95% CI, 0.39–0.63] vs. avatar HR = 0.40 [95% CI, 0.31–0.52]) and the classification properties for the observational study (original AUC = 99.46 (s.e. 0.25) vs. avatar AUC = 99.84 (s.e. 0.12)). Once validated by privacy metrics, anonymous synthetic data enable the creation of value from sensitive pseudonymized data analyses by tackling the risk of a privacy breach.
Colorimetric response in polydiacetylene at the single domain level using hyperspectral microscopy
Authors: Chen Jiali , Zheng Jianlu , Hou Yuge , Sugihara Kaori
Published: March 2023

The colorimetric response of polydiacetylene was observed at the single microdomain level via hyperspectral microscopy, revealing the blue-to-red transition patterns unique to each stimulus.
Disturbance of intermolecular forces: eutectics as a new tool for the preparation of vapor-phase deposition precursors
Authors: Land Michael A. , Robertson Katherine N. , Clyburne Jason A. C. , Barry Seán T.
Published: March 2023

Mixing two volatile molybdenum(vi) compounds results in an eutectic which significantly lowers the melting point of the individual components, without reducing their volatility.
Well-dispersed Au co-catalyst deposited on a rutile TiO2 photocatalyst via electron traps
Authors: Akiyama Tomoki , Nagakawa Haruki , Tatsuma Tetsu
Published: March 2023

Au–TiO2 photocatalysts were prepared using electrons trapped in oxygen vacancies of TiO2. Their Au dispersibility and hydrogen production ability are higher than those prepared using a conventional photodeposition method.
Quantitative electrical homogeneity assessment of nanowire transparent electrodes
Authors: Grazioli Davide , Dadduzio Alberto C. , Roso Martina , Simone Angelo
Published: March 2023

We propose a computational method to assess the areal power density distribution in nanowire conduction networks. The method is employed to investigate electrical homogeneity dependence on nanowire content and nanowire-to-junction resistance ratio.
Covalent organic frameworks (COFs): a promising CO2 capture candidate material
Authors: Wang Xiaoqiong , Liu Haorui , Zhang Jinrui , Chen Shuixia
Published: March 2023

Covalent organic frameworks (COFs) are an emerging kind of porous crystal material.
A Predictive machine-learning model for propagation rate coefficients in radical polymerization
Authors: Van de Reydt Emma , Marom Noam , Saunderson James , Boley Mario , Junkers Tanja
Published: March 2023

Using ridge regression, the propagation rate coefficients for radical polymerization are correlated with basic molecular properties.
Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage
Authors: Sun Ruirui , Zhao Yuqian , Wang Wenjuan , Liu Jun-Jie Gogo , Chen Chunlai
Published: March 2023

A positively-charged-residue enriched alpha helix in the REC2 domain serving as a conserved element to facilitate one-dimensional diffusion-driven target search of Cas12a and assisting target cleavage of AsCas12a.
Extending the analogy between intracellular motion in mammalian cells and glassy dynamics
Authors: Corci Beatrice , Hooiveld Oscar , Dolga Amalia M. , Åberg Christoffer
Published: March 2023

The motion of mitochondria in mammalian cells resembles the motion in glassy systems.
Theoretical exploration on the activity of copper single-atom catalysts for electrocatalytic reduction of CO2
Authors: Min Junyong , Liu Lei , Chen Fengjuan , Jin Xuekun , Yuan Tianjiao , Yao Xiaoqian
Published: March 2023

Modulating the structure and coordination environment can effectively improve the CO2RR activity and selectivity of single atom copper catalysts.
Development of an exogenous coreactant-free electrochemiluminescent sensor for sensing glucose
Authors: Zuo Maoding , Cui Lin , Wang Shuangwen , Wei Wengui , Gao Wenqiang , Zhang Chun-yang
Published: March 2023

We developed a coreactant-free electrochemiluminescent sensor based on a hydrazone-linked covalent organic framework for sensing glucose.
Recent developments in nickel-catalyzed asymmetric cyclization and cycloaddition of carbonyl-alkynes, cyano-alkynes, and enynes
Authors: Yan Jun , Shi Min , Wei Yin
Published: March 2023

This Highlight overviews recent advancements in the past eight years (since 2015) in nickel-catalyzed asymmetric cyclization and cycloaddition of alkynes with unsaturated functional groups.
High stability and moderate second-order nonlinear optical properties of hybrid lead-free perovskite [(CH3)3NCH2Cl]CdCl3 bulk crystals
Authors: Shen Chuanying , Liu Jie , Wu Kui , Xu Longyun , Sun Defu , Dang Yangyang , Wang Jiyang , Wang Duanliang
Published: March 2023

A wide transparent region (200–900 nm) and distorted octahedrons led to moderate SHG of (TMCM)CdCl3.
Mesolysis of an asymmetric diphenyldisulfide radical anion studied by γ-ray and pulsed-electron radiolyses
Authors: Yamaji Minoru , Tojo Sachiko , Majima Tetsuro , Fujitsuka Mamoru
Published: March 2023

Which radical/anion pair will be formed upon one-electron reduction (mesolysis of radical anion)?
Ligand–metal cooperativity in quinonoid based nickel(ii) and cobalt(ii) complexes for catalytic hydrosilylative reduction of nitriles to amines: electron transfer and mechanistic insight
Authors: Paramanik Krishnendu , Bandopadhyay Nilaj , Sarkar Gayetri , Chatterjee Souvik , Roy Suvojit , Panda Subhra Jyoti , Purohit Chandra Shekhar , Biswas Bhaskar , Das Hari Sankar
Published: March 2023

Non-innocent quinonoid ligand based square-planar Ni(ii) and Co(ii) complexes showing excellent catalytic activity towards hydrosilylative reduction of nitrile to corresponding primary amine using an inexpensive hydrosilane PMHS.
Immunoglobulin adsorption and film formation on mechanically wrinkled and crumpled surfaces at submonolayer coverage
Authors: Gole Matthew T. , Dronadula Mohan T. , Aluru Narayana R. , Murphy Catherine J.
Published: March 2023

Understanding protein adsorption behavior on rough and wrinkled surfaces is vital to applications including biosensors and flexible biomedical devices.
Depolarization induced III–V triatomic layers with tristable polarization states
Authors: Ke Changming , Hu Yihao , Liu Shi
Published: March 2023

The depolarization field is employed as a physical stressor to design switchable III–V two-dimensional tristable polar materials with promising compatibility with silicon, potentially enabling multibit-based nanoelectronics.
An ultralight aerogel-type urea absorbent for the development of a wearable artificial kidney
Authors: Yuan Yaping , Li Jing , Guo Chenyuan , Zhang Lili , Song Yuyan , He Yanli , Luo Yankun , Shen Shuguang
Published: March 2023

Cellulose aerogel is used for urea adsorption for the first time, and displays a fast adsorption rate and high adsorption capacity.
Multiple fluorescence-temperature feedback in Y7O6F9:Er/Yb crystal-embedded polyacrylonitrile fibers
Authors: Liu Z. , Li Y. , Zhao X. , Pun E. Y. B. , Lin H.
Published: March 2023

The Y7O6F9:Er/Yb crystal-embedded polyacrylonitrile fibers with multiple fluorescence-temperature sensitivity, flexibility, and reusability.
Improving the performance of biomass-based electrocatalysts by means of hot pressing
Authors: Huang Tianhao , Zhang Wendu , Liu Weiqi , Wei Shilin , Geng Wujun , Xia Xue , Xu Lang
Published: March 2023

To address the problem of decoupling arising from weak binding of extrinsic agents to biomass, we propose a hot-pressing method by which heterogeneous solids become firmly integrated in confined spaces at elevated temperatures and pressures.
Hyperdoped Si nanocrystals embedded in silica for infrared plasmonics
Authors: Zhang Meiling , Poumirol Jean-Marie , Chery Nicolas , Rinnert Hervé , Giba Alaa E. , Demoulin Rémi , Talbot Etienne , Cristiano Fuccio , Hungria Teresa , Paillard Vincent , Gourbilleau Fabrice , Bonafos Caroline
Published: March 2023

Plasmonic hyperdoped Si nanocrystals embedded in silica synthesizedviaa combination of sequential low energy ion implantation and rapid thermal annealing.
Stereoselective synthesis of vinyl nitriles through a Ramberg–Bäcklund approach
Authors: Valle-González Octavio A. , Salazar-Bello Ángel I. , Armando Luján-Montelongo J.
Published: March 2023

A new method for synthesizing aryl and heteroaryl vinyl nitriles is demonstrated, with a practical application in a formal synthesis of an anti-HIV antiviral.
Electroreduction of CO2 to syngas with controllable H2/CO ratios in a wide potential range over Ni–N co-doped ultrathin carbon nanosheets
Authors: Gan Kaining , Li Hongqiang , Li Ran , Niu Jiabao , He Jun , Jia Dedong , He Xiaojun
Published: March 2023

Electrocatalytic reduction of CO2 to syngas with tunable proportions in a wide potential range over Ni–N co-doped ultrathin carbon nanosheets.
A room-temperature moisture-stabilized metal-free energetic ferroelectric material for piezoelectric generation
Authors: Wang Jun , Chen Xiao-Xian , Ye Le , Gong Ya-Ping , Shang Yu , Zhang Wei-Xiong
Published: March 2023

The metal-free energetic material DAP-M4 is a rare room-temperature moisture-stabilized ferroelectric crystal simultaneously exhibiting an exploitable piezoelectricity.
Hydrothiolation of alkynes with thiol–catechol derivatives catalysed by CuNPs/TiO2: exploring the reaction mechanism by DFT calculations
Authors: Capurso Matías , Radivoy Gabriel , Nador Fabiana , Dorn Viviana
Published: March 2023

Based on experimental results and DFT studies, a detailed reaction mechanism is presented for the CuNPs/TiO2-catalysed hydrothiolation of activated alkynes with thiols bearing a catechol group.
Gold and palladium supported on an ionic liquid modified Fe-based metal–organic framework (MOF) as highly efficient catalysts for the reduction of nitrophenols, dyes and Sonogashira–Hagihara reactions
Authors: Karimi Shirin , Gholinejad Mohammad , Khezri Rahimeh , Sansano José M. , Nájera Carmen , Yus Miguel
Published: March 2023

Novel supported noble metals, on an ionic liquid modified Fe-based metal–organic framework (MOF), are considered as an efficient catalyst.
Development and validation of an UPLC-ESI-MS/MS method for quantification of duvelisib in plasma: application to pharmacokinetic study in rats
Authors: Darwish Ibrahim A. , Alzoman Nourah Z. , Almomen Aliyah , Almehizia Abdulrahman A. , Attwa Mohamed W. , Darwish Hany W. , Sayed Ahmed Y.
Published: March 2023

Duvelisib (DUV) is a new oral phosphoinositide-3-kinase (PI3K)-δ and PI3K-γ inhibitor.
New silicon substituted BiMeVOx: synthesis and study of structural properties in relation to ionic conductivity
Authors: Agnanou A. , Mhaira W. , Essalim R. , Zamama M. , Mauvy F. , Alga M. , Ammar A.
Published: March 2023

Partial substitution of vanadium with silicon in the compound Bi4V2O11, which belongs to the Aurivillius family, leads to the creation of a solid solution Bi4V2−xSixO11−δ (0 ≤ x ≤ 0.4).
Tribological performance of electrically conductive and self-lubricating polypropylene–ionic-liquid composites
Authors: Gatti Samuel Franz , Gatti Felix , Amann Tobias , Kailer Andreas , Moser Kevin , Weiss Patrick , Seidel Claudia , Rühe Jürgen
Published: March 2023

Improved friction and electrical conductivity through self-lubricating polypropylene composites with embedded ionic liquids and carbon-based fillers.
Pyrazole-based lamellarin O analogues: synthesis, biological evaluation and structure–activity relationships
Authors: Dzedulionytė Karolina , Fuxreiter Nina , Schreiber-Brynzak Ekaterina , Žukauskaitė Asta , Šačkus Algirdas , Pichler Verena , Arbačiauskienė Eglė
Published: March 2023

Isosteric pyrrole–pyrazole exchange in the natural alkaloid lamellarin O resulted in 18 fully characterized derivatives. Obtained compounds were investigated as potent agents against human colon cancer cell lines HCT116, HT29 and SW480.
Fabrication of Ru nanoclusters on Co-doped NiSe nanorods with efficient electrocatalytic activity towards alkaline hydrogen evolutionviahydrogen spillover effect
Authors: Mu Ce , Xin Hongqiang , Luo Qiaomei , Li Yan , Ma Fei
Published: March 2023

The hydrogen spillover strategy was demonstrated to enhance the HER activity of Ru in alkaline electrolytes through Co doping into NiSe. 1.5 wt% Ru–Ni0.85Co0.15Se/NF with a smaller |ΔΦ| value showed a superior HER performance and stability.
A day in the life of a research associate in bioinformatics
Authors: Patel Krutik
Published: March 2023

Dr Krutik Patel has recently completed his PhD in bioinformatics at Newcastle University and has since been employed as a research associate. His interests are in applying data science techniques applying data science techniques to answer interesting questions in biology and developing software for researchers. He started his undergraduate training in genetics at the University of Manchester and also completed his MSci project there.
How the Charter Members of ASHA Responded to the Social and Political Circumstances of Their Time
Authors: Duchan Judith Felson , Hewitt Lynne E.
Published: March 2023

Purpose:

This article examines the responses of the founders of the American Speech-Language-Hearing Association (ASHA; original name, the American Academy of Speech Correction) to the social trends of their day in the United States. Those trends included migrations from Europe and the rural South, the emergence of new scientific methodologies, and the birth of a professional class. Our aims are to reveal how the founders reacted to these select social changes, to show how their reactions served to shape the newly formed profession in and around 1925, and to describe how that profession is still grappling with their choices even today.

Method:

The writings of the founding members of ASHA were examined for evidence of their views in relation to 20th century historical trends, specifically examining their attitudes toward clients and clinical practice.

Results:

We identified elitist, ethnocentric, racist, regionalist, classist, and ableist statements in the writings of the founders. They promoted practices that denigrated those speaking dialects that were deemed nonstandard, including linguistic patterns originating from ethnic, racial, regional, and class differences. They also used ableist language in writing about people with communication disabilities, adopting a medical model that elevated the professional practitioner over the client.

Conclusions:

Our founders' response to social and political trends led to their creation of oppressive professional practices rather than to work within a more positive social model of professional practice, which was readily available to them at the time, one that would have embraced differences rather than seeking to erase them. Once again, we are experiencing sea changes in our society, ones that offer us the opportunity to reverse the practices shaped by our predecessors. We can learn from the missteps of our founders to create practices that empower and respect those with communication differences or disabilities.

Supplemental Material:

https://doi.org/10.23641/asha.22213738
Taylor‐based adaptive sliding mode control method for robot manipulators
Authors: Fateh Alireza , Momeni Hamidreza , Masouleh Mehdi Tale
Published: March 2023

This paper develops a novel Taylor‐based adaptive sliding mode control method (ASMC) for robot manipulators. In the first new scheme, sliding mode control (SMC) is effectively enhanced using the Taylor expansion for achieving a less conservative sign‐function gain that enables chattering attenuation. After that, a new Taylor‐based adaptive SMC scheme is proposed without prior knowledge of the upper bound of uncertainty and the Taylor expansion coefficients. Then, a new Taylor‐based boundary layer ASMC scheme is proposed for chattering attenuation. As a fact, no chattering is expected to be observed as long as the sliding surface remains an invariant set. However, the sliding surface will not be an invariant set unless the sign‐function is precisely determined on the sliding surface. It is verified that the sign‐function cannot be precisely determined on the sliding surface due to the presence of uncertainty, hence, the chattering phenomenon. In the new Taylor‐based boundary layer ASMC scheme, the conventional ASMC is modified by removing the sign‐function in the vicinity of the sliding surface and using the Taylor expansion to estimate and compensate for the uncertainty. Compared to a time‐delay ASMC applied to a robot manipulator, the Taylor‐based ASMC scheme exhibits a less conservative sign‐function gain resulting in chattering attenuation.
Photovoltaic model parameters identification using an innovative optimization algorithm
Authors: El‐Dabah Mahmoud A. , El‐Sehiemy Ragab A. , Hasanien Hany M. , Saad Bahaa
Published: March 2023

As it tackles electrical and non‐electrical losses, the triple‐diode model (TDM) of photovoltaic (PV) cells is highly exact. This paper employs a novel optimization method known as the innovative optimization algorithm (INFO) technique to correctly estimate the electrical characteristics of such TDM. To shift agents towards a better position, the INFO algorithm exploits the concept of weighted mean. The primary goal of INFO is to stress its performance features to solve some optimization difficulties that other approaches cannot effectively solve. In this paper, the objective function based on a combination of the absolute value of the current error, its squared value, and its quadrable value is employed, which the INFO optimizer minimizes to predict the optimum parameters of such TDM precisely. The proposed INFO algorithm is carried out on multi‐ and mono‐crystalline varieties, such as the Kyocera KC200GT and the Canadian Solar CS6K‐280 M. The simulation outcomes demonstrate the INFO's ability to extract the model parameters precisely. The INFO achieved the lowest ideal fitness values of 9.0738 × 10−06 and 5.7356 × 10−05 for the KC200GT and Canadian Solar CS6K‐280 M, respectively, throughout the optimization procedure. Under various environmental circumstances, experimental validation of the calculated parameters using the (INFO) optimizer is carried out, and the results are compared to the observed values from the laboratory experiments. The simulation results demonstrate the INFO's convergence time and accuracy advantage over competing optimization techniques. Additionally, statistical analysis shows that the INFO optimizer is resilient.
A novel automated demand response control using fuzzy logic for islanded battery‐operated rural microgrids
Authors: Azeem Fawad , Memon Zulfiqar Ali , Baig Sobia , Manzoor Tareq , Abbas Faisal , Shah Mohd Asif
Published: March 2023

Islanded rural microgrid require continuous resource monitoring. Demand response schemes have been phenomenal in managing loads. However, urban demand response schemes are well equipped with market prices and peak time penalties to control deferrable loads. In rural microrids, regular loads such as fans, lights and water pumps are normally used that do not fall under category of deferrable loads. In addition, full liberty of utilizing regular load at any time, lack of awareness and no information of storage reserves make task of load management more complex. In this research fully automated two layered demand response scheme is designed for regular operating loads. The first layer control is load mode control. The mode of operation is decided on the state of charge (SoC) of battery. In second layer, fuzzy controller is designed on the consumer's routines, SoC and ambient temperature as membership function. Results are assessed in terms of consumers comfort and availablity of SoC. The load operation in automated demand response remained indentical to actual rutine operation as per consumer's desire with 5 to 7% deviation. In all modes of operation SoC levels remained 15% higher and heavy load operated 13.5% more compare to relevant study.
Robust networked power system load frequency control against hybrid cyber attack
Authors: Lv Xinxin , Sun Yonghui , Dinavahi Venkata , Zhao Xinlong , Qiao Feng
Published: March 2023

Modern network and communication technologies are essential for the implementation and operation of load frequency control (LFC) systems. The measurements of crucial LFC system parameters will be compromised by attackers, rendering data received by the defence inaccurate and causing frequency fluctuations or even system collapse. To detect the potential attack on measured data and keep the LFC performance, an adaptive event‐triggered scheme with fractional order global sliding mode control scheme is proposed in this paper. Furthermore, Markov theory is employed for the modelling process with energy storage to present a multi‐area LFC power system considering renewable energy and hybrid cyber attacks. Stability and stabilisation criteria are built by employing improved Lyapunov stability theory and second‐order Bessel‐Legendre inequality. Finally, a two‐area LFC system under hybrid cyber attacks and a modified IEEE 39‐bus New England test power system with 3 wind farms are simulated to explore the efficacy of the proposed method.
An embedded and intelligent anomaly power consumption detection system based on smart metering
Authors: Lazim Qaddoori Sahar , Ali Qutaiba Ibrahim
Published: March 2023

User behaviour, human mistakes, and underperforming equipment contribute to wasted energy in buildings and industries. Identifying anomalous consumption power behaviour can help to reduce peak energy usage and change undesirable user behaviour. Furthermore, decreasing energy consumption in buildings is difficult because usage patterns vary from one building to the next. So, the main contribution in this manuscript is to propose a lightweight architecture for smart meter to identify abnormalities in power consumption for each building individually using machine learning (ML) models and implement on a Single Board Computer. To detect daily and periodic pattern anomalies, two models of anomaly detection based on supervised and unsupervised ML algorithms are built and trained where numerous algorithms were utilised to select the best algorithm for each model. Also, the proposed approach enables iterative procedure modifications by retraining the two anomaly detection models on data aggregator server based on the received data meter from the specific smart meter to give better power service to clients while minimising provider losses. The effectiveness and efficiency of the suggested approach have been proven through extensive analysis.
Influence of unregulated storage conditions on physico-chemical, organoleptic and NIR spectral characteristics of yellow cheese
Authors: Baycheva Stanka , Zlatev Zlatin , Veleva Petya
Published: March 2023

In the present work, software and hardware tools are proposed for determining the change in the main characteristics of Bulgarian yellow cheese during storage in conditions not regulated by the manufacturers. NIR images in the 800-1100 nm range of yellow cheese samples from 3 manufacturers were obtained using a GT-903 video camera with the IR-filter removed from the camera lens. Several physicochemical characteristics of the product were determined - active acidity, electrical conductivity and completely dissolved solids. Data from organoleptic evaluation of the product are presented. Using ABC- XYZ analysis, informative wavelengths are selected from the spectral features. Spectral indices calculated as ratios of the reflectance coefficients of selected wavelengths were defined and used to predict the storage characteristics of yellow cheese. It has been found that the shelf life of yellow cheese can be predicted with an accuracy of up to 95%, and the active acidity with an accuracy of up to 88%, depending on the manufacturer. The obtained results can be used for analyzes of yellow cheese during its storage and applied in automatic measurement and control systems, as well as in advisory systems for evaluating the quality of yellow cheese in the different stages of its production, transport and storage.
Edible pH sensitive polysaccharide-anthocyanin complex films for meat freshness monitoring
Authors: Solak Ayten , Dyankova Svetla , Doneva Maria , Pavlova Milena
Published: March 2023

One of the innovative methods for real-time determination of food freshness is the application of pH-indicator sensors, where the color change can be used for the visual detection of acidic/basic volatile compounds formed during product storage due to microbial growth. The aim of the present study is to develop a pH-responsive freshness indicator based on anthocyanins from chokeberry (Aronia melanocarpa Elliot) and black carrot (Daucus carota ssp. sativus var. atrorubens Alef.), incorporated into an alginate/pectin/arabic gum composite film. The resulting films show distinct color changes as the pH varies. The color changes from red (pH 2.0 - 3.0) through pink and pale pink (pH 4.0, 5.0 and 6.0) to purple and blue (pH 7.0 - 8.0). The most distinct is the color transition between pH 6.0 and 7.0 for the black carrot extract and the chokeberry: black carrot mixture (1:3). The applicability of the developed pH-indicator films was demonstrated in chicken meat by tracking the changes during its storage at 4°C for 7 d. The observed results show a distinct color change from pink (day 1-3) to violet and blue on day 7. The developed pH- sensitive films have potential for use in a smart packaging system as a sensor for meat freshness monitoring.
Study of the effect of treatment with aqueous extracts by oregano and wild basil on raw poultry meat
Authors: Dimitrov Nikolay , Dyankova Svetla , Solak Ayten , Miteva Daniela , Ivanova Silviya
Published: March 2023

The effect of treatment with aqueous antioxidant extracts of oregano (Origanum vulgare L.) and wild basil (Clinopodium vulgare L.) in refrigerated storage of raw poultry meat was studied. Physicochemical analyzes of meat samples were performed - total protein, ash, fat, dry matter, cooking loss and pH value in dynamics. The content of malondialdehyde (MDA) and the protein profile were determined. The microorganisms’ growth rate in meat during storage at 4°C for a period of 14 d was monitored. After the 7th d, the total number of mesophilic microorganisms in the meat samples increased to 7.00 log cfu/g, which is indicative of decay. A significant increase in pH value was observed after 14 d of storage, but there were no significant changes in total protein content and protein profile. In all meat samples, the amounts of MDA on days 7 and 14 were significantly below the thresholds indicated in the literature. Experimental groups treated with extracts showed lower values for MDA content compared to the control, which is an indication of certain inhibition of lipid oxidation processes in meat.
Physicochemical parameters of food emulsion products with summer savory (Satureja hortensis L.) essential oil
Authors: Lazarov Anton , Stankov Stanko , Fidan Hafize , Gandova Vanya , Stoyanova Albena
Published: March 2023

Summer savory (Satureja hortensis L.) is a plant source of essential oil belonging to the Lamiaceae family, widely used in the food industry. The present work aims to determine the physicochemical parameters of food emulsions containing the essential oil. The summer savory essential oil with main components carvacrol (63.71%), γ-terpinene (20.47%), and p-cymene (5.08%) was used in this study. Several model variants of emulsions have been developed with varying amounts of emulsifier (2 and 3% soy protein isolate), oil phase (20 and 40% sunflower oil), and essential oil (0.2 and 0.4%). The following physicochemical parameters of the emulsion were determined: Gibbs free energy, enthalpy, and entropy. This parameter was used to determine the thermal effect of the system. The process was determined as exothermic with the negative enthalpy. Emulsions prepared with 2% soybean protein isolate, 40% oil phase, and 0.4% essential oil were characterized by some good results with high equilibrium constants and high Gibbs energies. Model variants of salad diet dressings had also been developed, with 0.2 and 0.3% essential oil, which were qualified by sensory analysis. The overall evaluation of salad dressings showed that the evaluators perceived with best sensory properties in those with 0.2% essential oil.
Validation of method for analysis of glucose in food additives
Authors: Mladenov Metodi ,   for the ALICE Collaboration
Published: March 2023

The dangers of consuming various food and drink products containing substances with a potential risk to human health are the subject of increased interest. There is a drive among manufacturers and the scientific community to ensure safety in the use of various foods and beverages with proven and/or suspected links to one or another disease state. Fast and reliable methods of analysis are increasingly sought for the purpose of establishing the type and concentrations of the contained substances and elements, which methods support the implementation of strict control of the quantitatively regulated levels of various indicators, including main components and impurities. The current work presents a validation procedure of an iodometric method for determining the content of glucose as the main component of three types of nutritional supplements. To evaluate the method, results for the analytical characteristics specificity, repeatability, accuracy and linearity are presented and analyzed.
Was Homöopathie in einem Fall von akuter Pankreatitis beim
Hund zu leisten vermag – ein Fallbericht
Authors: Jürgens Ellen
Published: March 2023

Zusammenfasssung

Es wird ein Hund vorgestellt, der unter einer Protein-losing enteropathy und
Pankreatitis leidet. Aus einem Zustand der totalen Schwäche heraus wird er
mithilfe von Q-Potenzen und organotropen homöopathischen Arzneimitteln vor
der drohenden Euthanasie bewahrt.
Hypertensive Disorders of Pregnancy and the Cardiovascular System: Causes, Consequences, Therapy, and Prevention
Authors: Baschat Ahmet A. , Darwin Kristin , Vaught Arthur J.
Published: March 2023

Hypertensive disorders of pregnancy continue to be significant contributors to adverse perinatal outcome and maternal mortality, as well as inducing life-long cardiovascular health impacts that are proportional to the severity and frequency of pregnancy complications. The placenta is the interface between the mother and fetus and its failure to undergo vascular maturation in tandem with maternal cardiovascular adaptation by the end of the first trimester predisposes to hypertensive disorders and fetal growth restriction. While primary failure of trophoblastic invasion with incomplete maternal spiral artery remodeling has been considered central to the pathogenesis of preeclampsia, cardiovascular risk factors associated with abnormal first trimester maternal blood pressure and cardiovascular adaptation produce identical placental pathology leading to hypertensive pregnancy disorders. Outside pregnancy blood pressure treatment thresholds are identified with the goal to prevent immediate risks from severe hypertension >160/100 mm Hg and long-term health impacts that arise from elevated blood pressures as low as 120/80 mm Hg. Until recently, the trend for less aggressive blood pressure management during pregnancy was driven by fear of inducing placental malperfusion without a clear clinical benefit. However, placental perfusion is not dependent on maternal perfusion pressure during the first trimester and risk-appropriate blood pressure normalization may provide the opportunity to protect from the placental maldevelopment that predisposes to hypertensive disorders of pregnancy. Recent randomized trials set the stage for more aggressive risk-appropriate blood pressure management that may offer a greater potential for prevention for hypertensive disorders of pregnancy.

Key Points
Multimodal Management of Cervical Insufficiency Complicated by Intra-amniotic Candida albicans Infection
Authors: Chon Andrew H. , Monson Martha A. , Gomez Nicole G. , Butler-Wu Susan M. , Chmait Ramen H.
Published: March 2023

Introduction Bacteria are the most common pathogens implicated in ascending infections in patients with cervical insufficiency. However, Candida albicans is a rare and serious cause of intra-amniotic infection that should be considered on the differential diagnosis. Upon diagnosis following cerclage placement, patients are generally advised to undergo immediate cerclage removal and discontinuation of the pregnancy due to the high risk of maternal and fetal morbidity. However, some patients decline and instead elect to continue the pregnancy with or without treatment. Limited data exist to guide management of these high-risk patients.

Case Presentation We describe a case of previable intra-amniotic C. albicans infection diagnosed following physical examination–indicated cerclage placement. The patient declined pregnancy termination and subsequently underwent systemic antifungal therapy as well as serial intra-amniotic fluconazole instillations. Fetal blood sampling confirmed transplacental transfer of maternal systemic antifungal therapy. The fetus delivered preterm and without evidence of fungemia, despite persistently positive amniotic fluid cultures.

Conclusion In a well-counseled patient with culture-proven intra-amniotic C. albicans infection declining termination of pregnancy, multimodal antifungal therapy in the form of systemic and intra-amniotic fluconazole administration may prevent subsequent fetal or neonatal fungemia and improve postnatal outcomes.

Key Points
The Association of Perceived Labor Agentry and Depression and/or Anxiety
Authors: Whelan Anna R. , Recabo Olivia , Ayala Nina K. , Clark Melissa A. , Lewkowitz Adam K.
Published: March 2023

Objective Pregnancies complicated by perinatal mood disorders or a history of mental health disorder are at increased risk for complications including postpartum depression/anxiety. Patients' perceived control over childbirth is known to be an important factor for development of postpartum depression/anxiety. It is unclear whether women with preexisting and/or current depression and/or anxiety have different perceptions of control during childbirth compared with those without these comorbidities. This study aimed to evaluate the association between a current and/or prior diagnosis of depression and/or anxiety and scores on the Labour Agentry Scale (LAS), a validated tool evaluating patient's experience of control over their labor and delivery.

Study Design This is a cross-sectional study of nulliparous patients admitted at term to a single center. Participants completed the LAS after delivery. A trained researcher performed detailed chart reviews for all participants. Participants were identified as having a current or historical diagnosis of depression/anxiety by self-report confirmed by chart review. Scores on the LAS were compared between those with versus without a diagnosis of depression/anxiety prior to admission for delivery.

Results A total of 73 (44.8%) of the 149 participants held a current and/or prior diagnosis of depression and/or anxiety. Baseline demographics were similar between those with and without depression/anxiety. Mean scores on the LAS (range: 91–201) were significantly lower for those with depression/anxiety than those without a prior diagnosis (150.0 vs. 160.5, p < 0.01). Even after controlling for mode of delivery, admission indication, anesthesia, and Foley balloon usage, participants with anxiety and depression had scores that were on average 10.4 points lower on the LAS (95% confidence interval: −19.25, −1.62).

Conclusion Participants with a current and/or prior diagnosis of depression and/or anxiety scored lower on the LAS as compared with those without psychiatric diagnoses. Patients with psychiatric diagnoses may benefit from increased education and support during childbirth.

Key Points
Technical Characteristics of the Ovation Alto for the Treatment of Abdominal Aortic Aneurysms: Application to Challenging Anatomies
Authors: Georgakarakos Efstratios , Dimitriadis Konstantinos , Argyriou Christos , Efenti Gioultzan Memet , Doukas Damianos , Georgiadis George S.
Published: March 2023

The Ovation Alto design repositions the maximum diameter of the proximal sealing ring at 7 mm below the lowermost renal artery. Although it has been introduced to address abdominal aortic aneurysms with short necks ≥7 mm, we present further applications of Alto in other neck irregularities, presenting four representative challenging cases with a short, wide, and conical neck, as well a juxtarenal aneurysm. At 1-month follow-up, there was 100% technical and clinical success.
Characterization of Patients with Frequent Utilization of the Obstetric Triage Unit: A Retrospective Cohort Study
Authors: Nau Christopher , Benedict Jason , Cosgrove Casey , Shellhaas Cynthia , Hade Erinn , Ruberg Tara , Frey Heather A.
Published: March 2023

Objective This study aimed to identify characteristics of patients with frequent obstetric triage visits (“superusers”) compared to those with fewer visits and to evaluate the association of frequent obstetric triage visits with preterm birth and cesarean delivery.

Study Design This retrospective cohort included patients presenting to the obstetric triage unit at a tertiary care center from March through April 2014. Superusers were defined as individuals having four or more triage visits. Participant characteristics, including demographic, clinical, visit acuity, and health care characteristics of superusers and nonsuperusers, were summarized and compared. In the subset of patients where data were available regarding prenatal care, prenatal visit patterns were analyzed and compared between the two groups. The outcomes of preterm birth and cesarean were compared between groups using modified Poisson regression to control for confounding.

Results Of the 656 patients evaluated in the obstetric triage unit during the study period, 648 patients met the inclusion criteria. Factors associated with frequent triage use included race/ethnicity, multiparity, insurance status, high-risk pregnancy, and a prior preterm birth. Superusers were more likely to present at an earlier gestational age and had a higher proportion of visits for hypertensive disease. Patient acuity scores were not different between the groups. In the subset of patients receiving prenatal care at the institution, prenatal visit patterns were similar. The risk of preterm birth (adjusted risk ratio [aRR]: 1.06; 95% confidence interval [CI]: 0.66–1.70) did not differ between groups; however, the risk of a cesarean delivery was increased in superusers (aRR: 1.39; 95% CI: 1.01–1.92) when compared to nonsuperusers.

Conclusion Superusers, compared to nonsuperusers, have distinct clinical and demographic characteristics and are more likely to be seen in the triage unit at earlier gestational ages. Superusers tended to have a higher proportion of visits for hypertensive disease and had an increased risk of cesarean delivery.

Key Points
Aliphatic Acylhydrazides as Effective Alkylating Agents for the Copper-Catalyzed Oxidative Cyclization of N-Arylacrylamides
Authors: Tian Shi-Kai , Xie Dong , Tian Ren-Gui , Liao Jia-Jia
Published: March 2023

An unprecedented use of readily accessible aliphatic acylhydrazides as alkylating agents has been demonstrated in the copper-catalyzed tandem alkylation/cyclization of N-arylacrylamides. A range of aliphatic acylhydrazides smoothly participated in the oxidative 5-exo-trig cyclization of N-arylacrylamides with CuCO3 as the catalyst and DTBP as the oxidant, delivering structurally diverse 3,3-dialkyloxindoles in moderate to good yields. This study paves the way for the synthetic applications of aliphatic acylhydrazides as alkyl radical precursors.