bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of horizontal mergers on suppliers' cash holdings
Authors: Upson James E. , Wei Chao
Published: February 2025

We examine the impact of customer horizontal mergers on suppliers' cash holdings. We show that suppliers strategically reduce their cash holdings after the merger to counteract the increased bargaining power of merged customers. This effect is more pronounced when the supplier relies on customers and less when the supplier operates in a concentrated industry. Consistent with the bargaining power hypothesis of cash holdings, we find that cash‐reducing suppliers experience higher postmerger cash‐flow margins. Finally, we show that suppliers are more likely to use cash reserves to finance their research and development investments to credibly reduce liquidity.
Application of Artificial Intelligence Software to Identify Emotions of Lung Cancer Patients in Preoperative Health Education: A Cross‐Sectional Study
Authors: Chen Xiaoxue , Xin Ziya , Yang Dong , Song Xinyuan , Zhong Jiudi , Weng Jiahuan , Zhang Yongxue , Liu Dandan , Min Wang , Lu Kang , Juan Yuan
Published: February 2025

Aim(s)

To determine the correlation between preoperative health education and the emotions of lung cancer patients, artificial intelligence software was used.

Design

This was a cross‐sectional study.

Methods

This study included 210 lung cancer patients from Sun Yat‐sen University Cancer Center and examined the impact of health education on patient emotions using an AI‐based emotion analysis tool.

Results

This study indicated a significant relationship between the tone and emotional content of health education materials and patient emotions. Specifically, educational materials with an explanatory tone and negative sentiment appeared to impact patients' emotional states.

Conclusion

Quality improvements in health education can potentially benefit lung cancer patients' emotional well‐being by minimizing the use of both explanatory tone and negative sentiment in educational content.

Implications for the Profession and/or Patient Care

This research suggests that the careful crafting of health education materials, taking into consideration tone and emotional expressions, can have a tangible positive effect on the emotional state of lung cancer patients.

Reporting Method

The study was reported in accordance with the STROBE guidelines.

Patient or Public Contribution

No patients, service users, caregivers, or members of the public were involved in the design, conduct, collection, analysis, or interpretation of the data for this study, nor were they involved in writing the manuscript.
Laccaria friesii sp. nov. (Hydnangiaceae), a new species from northwestern Himalaya of Uttarakhand, India
Authors: Choudhary Shikha , Pal Sharma Yash , Uniyal Priyanka
Published: February 2025

Laccaria friesii is proposed here as a new species based on morphological characteristics and phylogenetic analyses of the nuclear rDNA internal transcribed spacer region. A combination of morphological and molecular data confirmed the novelty of the species and its placement within the genus Laccaria. This species was found in association with Rhododendron arboreum and Quercus leucotrichophora and is characterized by large basidiome (17–90 mm pileus diam.), convex to campanulate pileus with a central depression, wavy margins, pink fleshy brown distant lamellae, presence of versiform cheilocystidia and trichoderm type pileipellis.
A new species, Strobilanthes gigantea (Acanthaceae), from India
Authors: Chowlu Krishna , Maity Rohan , Ray Ajit , Althaf Ahamed Kabeer Kadher , Dash Sudhansu Sekhar
Published: February 2025

A new species, Strobilanthes gigantea, is described here from the state of Arunachal Pradesh, in the Indian Himalayan Region (IHR). The new species is immediately recognised by being very large – sometimes a tree, exhibiting densely imbricate bracts on uninterrupted inflorescence, slightly curved corolla tube with revolute lobes with emarginate apex, and presence of wings on the staminal curtain. A detailed description and photographs are provided to assist in its identification.
Infrastructural, performative and feral: Understanding agri‐environmental data relations in Aotearoa New Zealand
Authors: Edwards Sarah , Henry Matthew , Rosin Christopher
Published: February 2025

In agri‐environmental decision‐making, data are essential to defining problems and informing solutions. Nevertheless, it is important to consider not only how data can be used but also what data does in agri‐environmental contexts. We argue that the liveliness of data relations can be explored by attending to their infrastructural, performative and feral qualities. Taking digital agriculture and climate change adaptation as examples, we also consider how these interconnected theses could be applied. This critical approach to data relations and their generative effects will help avoid unintended consequences and shape alternative agri‐environmental futures.
Diet alters interspecific fecundity–size relationships in capital breeding insects
Authors: Lancaster Jill
Published: February 2025

Species' life history traits, such as fecundity, and how they co‐vary with other traits are central to models in population and community ecology. Within species, increasing fecundity with body size is often driven by nutritional quality of the diet. How and why fecundity varies among species is poorly understood but likely to be related, at least in part, to patterns of resource acquisition and allocation. This study tested for an interspecific, fecundity–size relationship among caddisfly species and tested whether fecundity covaried with larval diet. Data on fecundity and body size were collated for 102 species in 75 genera and 28 families from around the world. Species were assigned to one of four categories of larval diet (algivores, detritivores, filter‐feeders, predators) and also two combined diet groups, differentiated by the prevalence of animal versus plant material. A limiting relationship best described the positive association between fecundity and body size of all caddisflies, where size set an upper limit to fecundity. Diet explained variation below the upper limit. Compared to species with plant‐based diets, consumers of animal material had higher fecundity and diet‐specific fecundity–size relationships with steeper slopes. All relationships were hypoallometric (slopes less than 1), indicating a disproportionate effect of size on fecundity: in each diet group, large‐bodied species produced absolutely more, but proportionately fewer eggs than smaller‐bodied species, suggesting size‐related shifts in resource allocation. The largest species were detritivores, which is consistent with the Jarman–Bell principle that large animals are likely to have nutritionally poor diets. These diet‐related patterns in fecundity may lead to diet‐related patterns in population dynamics among species within freshwater communities that have not been considered previously.
Extensive Maxillary Defect and Oroantral Fistula Resulting From Medication‐Induced Osteonecrosis in a Patient Undergoing Oral Surgery
Authors: Marenucci Naellen Rampazzo , Sandoval Lara Gabriela Da Silva Barbosa , Costa Bruna da Silva , Rodrigues Kathiussa Fernanda Parreira , Bachesk Andressa Bolognesi
Published: February 2025

Osteonecrosis of the jaws is a severe condition associated with the use of anti‐resorptive therapies, such as bisphosphonates, which inhibit osteoclast activity and diminish bone repair capacity. Although the risk of osteonecrosis is generally low in patients undergoing oral administration of these medications, the potential for complications remains. A lack of awareness among dental surgeons about this condition often leads to the performance of surgical procedures without adequate pre‐ and post‐operative care, potentially resulting in significant complications and serious long‐term consequences.

Aim

This work aims to report a case of a patient undergoing treatment with bisphosphonates who faced post‐surgical complications after surgical procedures performed without the appropriate care.

Methods

The patient, a 73‐year‐old woman, underwent tooth extractions and dental implant removal while being on sodium alendronate therapy for 2 years. She developed maxillary sinusitis associated with an oroantral fistula and suffered severe loss of a significant portion of her left maxilla.

Results and Conclusion

For case management, surgical and conservative approaches were employed, including surgical debridement, flap creation for oroantral fistula closure, laser therapy, antibiotic treatment and the combination of a medication protocol with pentoxifylline and tocopherol. This underscores the importance of dental surgeons having comprehensive knowledge of osteonecrosis of the jaws and being equipped to manage these cases effectively, considering both clinical treatment strategies and the potential prevention of complications.
Critical Race Theory in Theological Education
Authors: Fears Barbara A.
Published: February 2025

Both the history of and the changing demographics within theological education demand a reckoning with the past, a close examination of the present, and a course correction for the future. Critical race theory (CRT), a framework currently under fierce political debate and intense public scrutiny, provides a lens for such a task. CRT is a misrepresented and misunderstood analytical tool that began in the field of law but has since spread to other disciplines including education and theology to study disparities across racial, religious, and gender lines. Although there is no canonical set of beliefs to which all CR theorists subscribe, in general, liberalism, claims of neutrality, objectivity, meritocracy, and colorblindness are rejected. Herein, I argue for the rejection of liberalism in theological education and offer recommendations to counter liberal tendencies in teaching, research, and service in the field.
A procedure using low‐cost reagents to prepare allogeneic platelet gel from standard platelet units
Authors: Mykhailova Larysa , Calvo Javier , Gafou Anthi , Garcìa Erce Josè Antonio , Lydaki Evangelia , Schinocca Maria Elena , Samarkanova Dinara , Scimemi Gabriele , Montemurro Tiziana
Published: February 2025

Background and Objectives

Highly effective procedures for the preparation of allogeneic platelet gel (PG) use Ca‐gluconate and batroxobin, an expensive commercial reagent. In this preliminary study, we explored the use of the plasmin‐inhibitor, low‐cost drug tranexamic acid (TXA) in place of batroxobin, based on the literature supporting TXA ability to prevent fibrinolysis and stabilize the gel formed by fibrin polymerization prompted by Ca‐gluconate.

Materials and Methods

Eight blood centres determined PG weight and volume of non‐gelled, liquid portion in 116 PG prepared in 20‐mL commercial BioNest D bags. Ten‐millilitre platelet aliquots from platelets in 100% plasma or in 35% plasma/65% platelet additive solution (PAS) were aseptically transferred into the D bag, followed by the injection of 3.3 mL of 10% Ca‐gluconate and 0.4 mL of TXA. After 30‐min incubation, PG weight and non‐gelled liquid volume were determined.

Results

PG weight and liquid volume at 30 min were 6.5 ± 3.4 g and 7.4 ± 3.5 mL with platelets in 100% plasma, and 3.7 ± 3.0 g and 10.2 ± 3.3 mL with PAS platelets, respectively.

Conclusion

This study provides preliminary evidence supporting the use of TXA as a low‐cost reagent for PG manufacturing from platelets in 100% plasma.
Combining Ultrasonic Pulse Velocity and Non-Linear Ultrasonic Techniques to Assess Concrete Strength
Authors: Alnuaimi Hamad , Amjad Umar , Alnuaimi Yousef , Kundu Tribikram
Published: February 2025

Non-Linear Ultrasonics (NLU) has grown in importance over the past years. The viability of applying the newly developed NLU technique called the Sideband Peak Count-Index (SPC-I) to estimate the 28-day unconfined compressive strength (UCS) of cylindrical concrete specimens is investigated. In addition, the SPC-I technique is combined with the conventional Ultrasonic Pulse Velocity (UPV) technique to achieve more precise UCS estimations than would be possible with a single estimation parameter. 16 conventional general purpose concrete specimens are cast utilizing Water-to-Cement (W/C) ratios of 0.4, 0.5, 0.55, and 0.6. To ensure reproducibility of results, experimental operations are performed utilizing consistent testing protocols and instruments. The SPC-I is determined to be a viable parameter that can be used to estimate the UCS value of concrete specimens with high accuracy. In addition, when the SPC-I is combined with the UPV, the resulting estimates become even more accurate and reliable than when utilizing only UPV values.
Recycled arc mantle underneath the Carlsberg Ridge, Indian Ocean: Caused by intraoceanic subduction of the Neo-Tethys Ocean
Authors: Huang Qiangtai , Chen Wenchao , Yu Haotong , Cao Yudong , Liao Yiyang , Zhang Chenglei , Hong Tao , Yin Zhengxin
Published: February 2025

Mid-oceanic-ridge volcanics of the Northwest Indian Ocean exhibit significant chemical and isotopic heterogeneities that indicate the presence of distinct mantle components beneath the ridge. In this study, we conducted a comprehensive petrological and geochemical investigation of two groups of Carlsberg Ridge basalts to determine the nature of their mantle source. Based on the geochemical data, the samples can be divided into two different groups. The first group, comprising whole-rock samples and corresponding volcanic glasses, is located at 2.8°N, and displays “arc-type” trace element patterns, including enrichment in fluid-mobile elements and depletion in Nb (e.g., high Pb/Ce, La/Nb, and Zr/Nb). Despite showing some signatures of seawater alteration, the second group, comprising whole-rock samples and located at 0°, displays similar rare earth element (REE) and high field strength element patterns and εNd as the first group, which suggests that they likely share a similar mantle source. Both groups are depleted in trace elements but isotopically enriched, with (La/Sm)N <0.8 and εNd <9. We propose that these lavas are products of the multistage melting of a mantle source that had been metasomatized by slab-derived fluids. Our study, combined with previously published Carlsberg Ridge data, lead us to suggest a widespread subduction influence in this region. Based on existing plate reconstruction, seismic tomography data, and geochemical evidence, we further propose that the current Carlsberg Ridge formed above the former site of the intraoceanic subduction of the Neo-Tethys Ocean. The arc mantle was integrated into the upwelling mantle and ultimately contributed to present-day Carlsberg Ridge mid-oceanic-ridge basalt (MORB).
Opioid-free versus opioid-based anaesthesia for free-flap reconstruction surgery of the breast: protocol for a phase III, multicentre, randomised controlled study
Authors: Saad-Boutry Mary , Carton Matthieu , Ezzili Cyrine , Savignoni Alexia
Published: February 2025

Introduction

Efforts have focused in recent decades on developing anaesthetic strategies that limit the use of morphine because of its known side effects. This study aims to compare postoperative morphine consumption between opioid-free anaesthesia (OFA) and conventional opioid-based general anaesthesia.

Methods and analysis

Phase III, multicentre, randomised controlled study comparing morphine consumption in the immediate postoperative period (first 48 hours) between OFA and conventional general anaesthesia (CGA). The study is conducted across three French academic cancer centres, with a planned enrolment of 158 patients, randomly assigned (1:1) to the OFA and CGA. The primary outcome is morphine consumption during the first 48 hours postoperatively.

Ethics and dissemination

The study has been approved by the National Research Ethics Committee (CPP, reference number 1-22−036/22.01675.000085) and the French National Agency for Medicines and Health Products Safety (ANSM, reference number MEDAECNAT-2022-04-0057). Written, informed consent to participate will be obtained from all participants. Results will be published in international peer-reviewed journals.

Trial registration number

This trial has been registered in the Clinical Trials in the European Union database (CTIS number: 2024-513308-32-00) and in ClinicalTrials.gov (NCT05439005).
Association of nocturnal oxygen saturation with coronary artery calcification: cross-sectional evidence from the population-based SESSA study among Japanese men
Authors: Mondal Rajib , Takashima Naoyuki , Torii Sayuki , Harada Akiko , Mohd Azahar Nazar , Moniruzzaman Mohammad , Kondo Keiko , Kadowaki Sayaka , Kadota Aya , Yano Yuichiro , Ueshima Hirotsugu , Miura Katsuyuki
Published: February 2025

Objective

We investigated the associations of nocturnal oxygen saturation (SpO2) with prevalence of coronary artery calcification (CAC) and its level of burden, and whether the associations differ by obesity and mediate through diabetes mellitus (DM), dyslipidaemia and hypertension.

Design

Observational study.

Setting

Kusatsu, Shiga.

Participants

We analysed data from 510 Japanese men (aged 46–76 years) with no history of myocardial infarction.

Primary and secondary outcomes

Mean SpO2, minimum SpO2and oxygen desaturation index (ODI) were measured using overnight pulse oximetry (primary exposures), while CAC was assessed using CT. Prevalence of CAC (>0) and its burden (CAC 0, >0–100, >100–400 and>400) were evaluated as outcomes. Body mass index≥25.0 kg/m2defined as obesity.

Results

Mean±SD age was 66.7±7.2 years. The prevalence of CAC was 64.7% (CAC scores>0–100, 31.4%; >100–400, 20.0% and>400, 13.3%). In multivariable binary logistic regression, the OR and 95% CI for the prevalence of CAC were 1.25 (1.02 to 1.53) per 1-SD decrement in mean SpO2and 1.25 (1.01 to 1.55) per 1-SD increment in ODI. The associations lost their significance while further adjusted for DM and dyslipidaemia. Similar trends were observed for the level of CAC burden in multivariable ordinal logistic regression. Obesity did not show significant interaction with SpO2on CAC. In mediation analysis, the OR (95% CI) for natural indirect effect; percentage mediated through dyslipidaemia in association of 1-SD decrement in mean SpO2with prevalence of CAC were 1.06 (1.01 to 1.10); 25.4%. These estimates for mediation through DM and dyslipidaemia for 1-SD increment in ODI in the associations were 1.07 (1.01 to 1.12); 29.6% and 1.04 (1.00 to 1.08); 17.5%, respectively.

Conclusions

Lower mean SpO2and higher ODI are associated with CAC among Japanese men, independent of age, lifestyle factors and obesity. The associations became non-significant after adjusting for diabetes and dyslipidaemia, but were mediated through these factors.
Reducing prematurity-related neonatal mortality: a quality improvement project in Gandhi Memorial Hospital, Addis Ababa, Ethiopia
Authors: Wotango Biniam Yohannes , Workneh Wubet Mihretu , Abdana Tariku Deressa , Kidane Hailegebriel , Alemayehu Mahlet , Niku Dawit , Alene Birtukan , Aragaw Aynekulu , Belay Zafu , Adenew Tigist , Hailu Gebremeskel Tamene , Haile Yeneneh Getachew
Published: February 2025

Background

Neonatal deaths refer to infants who die within the first 28 days of life, and they account for almost 50% of all child deaths under the age of 5 globally. Preterm birth is the primary reason for neonatal deaths, and it can lead to various complications that may prove fatal for newborns, such as respiratory distress syndrome, sepsis and intracranial haemorrhages. There was a high rate of neonatal mortality at Gandhi Memorial Hospital. 57.7% of neonatal deaths were caused by premature-related problems according to Pareto chart analysis. The baseline mortality rate among premature neonates admitted to the Neonatal Intensive Care Unit (NICU) was 20.7%. The objective of this quality improvement project was to reduce prematurity-related neonatal death at Gandhi Memorial Hospital.

Methods

A multidisciplinary quality improvement team used a fishbone diagram to analyse the causes of neonatal deaths related to prematurity. We used the Institute for Healthcare Improvement (IHI) model for improvement, using Plan-Do-Study-Act cycles to measure progress and make data-driven decisions.

Interventions

Transporting premature neonates born in the labour ward to NICU with CPAP, increasing the use of a continuous positive airway pressure (CPAP) device with an integrated oxygen concentrator, blender and compressor, and implementing the infection prevention checklist with four components were the implemented change ideas.

Results

The run chart showed a 25.6% reduction in prematurity-related neonatal mortality after implementing three interventions, and evidenced by a shift below the baseline median.

Conclusion and recommendation

The quality improvement project involving three interventions which are transporting premature neonates from labour ward to NICU with CPAP, using a CPAP device with an integrated oxygen concentrator, blender and compressor for preterm neonates and infection prevention checklist use with four components at Gandhi Memorial Hospital effectively reduced prematurity-related neonatal death. To improve neonatal outcome in premature neonates, we recommend that hospitals should prioritise implementing a standardised CPAP transport protocol, increasing a CPAP device with an integrated oxygen concentrator, blender and compressor use in the NICU, and fully implementing the infection prevention Checklist.
Predictors of early disability accumulation in newly diagnosed multiple sclerosis: clinical, imaging and cerebrospinal fluid measures
Authors: Lauerer Markus , Wiltgen Tun , Brückner Carolin , Engl Christina , Giglhuber Katrin , Lambrecht Sebastian , Pongratz Viola , Berthele Achim , Gasperi Christiane , Kirschke Jan S , Zimmer Claus , Hemmer Bernhard , Mühlau Mark
Published: February 2025

Background

A growing arsenal of treatment options for relapsing multiple sclerosis (RMS) emphasises the need for early prognostic biomarkers. While evidence for individual markers exists, comprehensive analyses at the time of diagnosis are sparse.

Methods

Brain and spinal cord lesion numbers, cerebrospinal fluid parameters, initial symptoms, and Expanded Disability Status Scale (EDSS) score were determined at the time of diagnosis. Confirmed disability accumulation (CDA), defined as a sustained EDSS increase over 6 months, was determined during a 5-year follow-up. All-subsets multivariable logistic regression was performed to identify predictors of CDA. Model performance was assessed via receiver operating characteristic analysis, and individual risks were calculated. Analyses were repeated with progression independent of relapse activity (PIRA) as an outcome.

Results

113/417 (27.1%) people with RMS experienced CDA on follow-up. Intrathecal IgG synthesis, a higher number of spinal cord lesions, age and polysymptomatic manifestation were identified as independent predictors of CDA. The resulting prediction model yielded an area under the curve (AUC) of 0.75 with a 95% CI of 0.70 to 0.80. Individuals exceeding the optimal thresholds for the three most significant predictors had a 61.8% likelihood of experiencing CDA, whereas those below all three thresholds had a CDA rate of 4.5%. The only significant baseline predictor differentiating PIRA from relapse-associated worsening was a higher number of spinal cord lesions (AUC=0.64, 95% CI 0.54 to 0.74).

Conclusions

Intrathecal IgG synthesis, spinal cord lesion number, age and polysymptomatic manifestation are independent predictors of early CDA in newly diagnosed RMS.
Microcosting analysis of percutaneous coronary intervention with and without intracoronary imaging in an Irish tertiary referral centre
Authors: Gallen Rory A , O’Mahony James F , M Kuntz Karen , McGorrian Catherine , Casserly Ivan P , J Blake Gavin
Published: February 2025

Background

Percutaneous coronary intervention (PCI) is a well-established treatment for coronary artery disease, one of the most significant causes of morbidity and mortality worldwide. Intracoronary imaging, including intravascular ultrasound (IVUS) and optical coherence tomography (OCT), has been shown to improve outcomes for patients following PCI by reducing complications and the need for repeat procedures. Uptake remains highly variable, in part due to concerns over up-front costs.

Aim

The purpose of this micro-costing analysis was to establish the costs and resource implications of PCI with and without intracoronary imaging.

Methods

The costing model considered costs associated with the index procedure and related hospital admission and was designed using data obtained from primary data collection, previously published literature and expert opinion. Unit costs were established through communication with the hospital finance department and industry representatives and were reported in 2024 euro. Costs were categorised as staffing, capital and consumables. Staffing costs were calculated in accordance with local guidelines. Capital costs were averaged over a 10-year period. A sensitivity analysis was conducted to assess the impact of the use of IVUS and OCT during PCI.

Results

The use of intracoronary imaging extends the average procedure time from 45 min to 60 min. The total procedural cost of PCI without intracoronary imaging was €3082. The incremental cost with intracoronary imaging was €752 for IVUS and €884 with OCT.

Conclusion

This study provides robust data on the cost drivers of PCI with intracoronary imaging in Ireland which has not previously been described. This framework may be of use to finance departments and physicians alike when seeking to establish the cost and resource implications of future modifications to PCI procedures, such as the description of the impact of intracoronary imaging in this study.
Cost-effectiveness of a community first responder system for out-of-hospital cardiac arrest in Belgium
Authors: de Greef Bianca , Genbrugge Cornelia , Verma Sanjay , Medic Goran , Maurer Joachim , Kooy Tom A , Hoogmartens Olivier , Sabbe Marc
Published: February 2025

Objective

Out-of-hospital cardiac arrest (OHCA) is a major public health challenge across Europe, with a survival rate of only 8.5% to hospital discharge. Implementing a community first responder (CFR) system, including earlier Basic Life Support and defibrillation, can enhance survival rates and neurological outcomes. This study assesses the cost-effectiveness of two scenarios for implementing such a system in Belgium.

Methods

A decision tree and the long-term Markov model were used to evaluate cost-effectiveness by comparing two scenarios with current care standards. Scenario 1 involved an awareness campaign on OHCA, while Scenario 2 included implementing a CFR system with automated external defibrillator (AED) integration, dispatch centre linkage and training for citizen responders. The analysis covered survival to the emergency department, hospital, discharge and neurologically intact survival, with sensitivity analyses to test robustness.

Results

The awareness campaign and implementation of the CFR system resulted in an incremental cost-effectiveness ratio of €14,976 and €16,442 per quality-adjusted life year gained for scenarios 1 and 2, respectively. Both scenarios showed improvements in survival rates at various stages, including hospital discharge and neurologically intact survival.

Conclusion

This study highlights the benefits of enhancing Belgium’s CFR for OHCA patients. It suggests that accessible AEDs, trained CFRs and an integrated emergency response system could improve survival rates and quality of life. These findings can guide policy and resource decisions, potentially improving the effectiveness and cost-efficiency of OHCA emergency services. Additionally, this approach could serve as a model for other regions aiming to strengthen their response to time-sensitive emergencies.
Handoffs and transitions of care in the intensive care unit: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document
Authors: Appelbaum Rachel D , Farrell Michael S , Hoth J Jason , Jung Hee Soo , Pathak Abhijit , Nassar Aussama K , Cuschieri Joseph , Stein Deborah M , Agapian John V
Published: February 2025

Objectives

The American Association for the Surgery of Trauma (AAST) Critical Care Committee chose handoffs and transitions of care in the intensive care unit (ICU) as a clinically relevant topic for review. This clinical consensus document aims to provide practical guidance to the surgical intensivist on the best practices for patient handoffs and transitions of care.

Methods

A working group was formed from the committee-at-large to complete this work. The members of the working group were each assigned a subtopic to review using research to date. The research on which the recommendations are based was compiled at the discretion of the working group. Any topic with discrepant or minimal supporting literature was reviewed by the AAST Critical Care Committee through an anonymous survey.

Results

Recommendations for healthcare handovers include formally recognized handoffs at dedicated times, an interactive verbal exchange including all patients with a focus on what to anticipate or what is needs to be completed, tools to record and maintain information, and training to new providers on the handoff process and technology.

Conclusion

As clinicians, we strive to provide the best evidence-based care to our patients. It is essential to study these high states, ICU handoffs to enhance the safety, efficiency, and effectiveness of patient care transitions, ultimately leading to better patient outcomes and provider satisfaction.

Level of evidence

V.
The precession of particle spin in spherical symmetric spacetimes
Authors: Pang Xiankai , Jiang Qingquan , Xiang Yunchuan , Deng Gao-Ming
Published: February 2025

In this work, we will explore the precession of particle spins in spherical spacetimes. We first argue that the geometrical optics (WKB) approximation is insufficient, due to the absence of a glory spot in the backward scattering of massless particles, making an analysis of spin precession necessary. We then derive the precession equation assuming the spin is parallel transported, which is supported by the sub-leading order of the WKB approximation. The precession equation applies to both massless and massive particles. For particles moving at the speed of light, we show that spin is always reversed after backward scattering in any spherically symmetric spacetime, confirming the absence of a glory spot for massless particles. Finally, we solve the precession equation for Schwarzschild and Reissner–Nordström spacetimes and discuss the spin precession of massive particles, particularly in the non-relativistic limit. We find that, in Schwarzschild spacetime, the spin precession for particles moving with very small velocities compared to the speed of light depends only on the deflection angle, while in Reissner–Nordström spacetime, it also depends on the black hole charge, as revealed by the expansion derived from the strong lensing approximation.
RunMe: An adaptive sound system for running meditation
Authors: Tan Peng , Zhu Xiaofei , Bi Tao , Ren Xiangshi
Published: February 2025

Running has emerged as an alternative to traditional meditation practices that involve sitting with closed eyes. The rhythmic nature of running establishes a connection between mind and body to promote mindfulness and improve the overall experience and benefits of running. The use of technology-supported meditation is gaining attention in the fields of mental and physical wellness. However, existing meditation technologies primarily focus on one-way stimuli for sitting or walking meditation, with little emphasis on adaptive design and development for running meditation. To address this issue, we present the design framework and system development of RunMe, an adaptive sound system specifically designed for running meditation. RunMe integrates stimulation and regulation mechanisms to enhance adaptive data interactions between the sounds and runners’ biodata. We compared the significance of the RunMe group with three other groups: use of non-adaptive sound, use of favorite music and use of no music/sound. The results show that the RunMe group outperforms the other groups in attention regulation, body awareness, exercise motivation, and mindfulness. Importantly, RunMe has the potential to allow users to engage in running meditation without specialized equipment, making it accessible for daily practice. We also discuss the design framework and practical distinctions of RunMe, as well as the design implications and future directions for advancing running meditation.
Deep Learning for Cross-Domain Few-Shot Visual Recognition: A Survey
Authors: Xu Huali , Zhi Shuaifeng , Sun Shuzhou , Patel Vishal , Liu Li
Published: February 2025

While deep learning excels in computer vision tasks with abundant labeled data, its performance diminishes significantly in scenarios with limited labeled samples. To address this, Few-shot learning (FSL) enables models to perform the target tasks with very few labeled examples by leveraging prior knowledge from related tasks. However, traditional FSL assumes that both the related and target tasks come from the same domain, which is a restrictive assumption in many real-world scenarios where domain differences are common. To overcome this limitation, Cross-domain few-shot learning (CDFSL) has gained attention, as it allows source and target data to come from different domains and label spaces. This paper presents the first comprehensive review of Cross-domain Few-shot Learning (CDFSL), a field that has received less attention compared to traditional FSL due to its unique challenges. We aim to provide both a position paper and a tutorial for researchers, covering key problems, existing methods, and future research directions. The review begins with a formal definition of CDFSL, outlining its core challenges, followed by a systematic analysis of current approaches, organized under a clear taxonomy. Finally, we discuss promising future directions in terms of problem setups, applications, and theoretical advancements.
Acute Respiratory Distress Syndrome in Young Postrenal Transplant Patients Receiving Basiliximab
Authors: Sivanesam Kalkena , Breeden Scott K. , Brannan Stephen
Published: February 2025

Renal transplants have been increasing in number due to the rise in end‐stage renal disease (ESRD) worldwide. Transplant is a good approach to management of renal disease, as it offers patients a better quality of life. However, complications such as acute graft rejection remain a concern in all transplant patients. Basiliximab is an antibody commonly used as part of acute rejection prevention in renal transplantation. This antibody has been demonstrated to have comparable efficacy as other agents currently used, with the added benefit of decreasing the amount of steroids required for adequate immunosuppression. The general side effect profile for basiliximab includes infection, gastrointestinal disturbance, hypertension, and hyperkalemia. Respiratory system‐related effects include dyspnea and upper respiratory tract infections, most of which have been documented to be mild or moderate in severity. However, a search of the literature reveals that there are a few reported cases of severe respiratory side effects in patients receiving basiliximab after renal transplants. In this report, we discuss two separate cases of acute respiratory distress syndrome (ARDS) that occurred in two young male patients. Both patients were without any other comorbidities, who had recently undergone renal transplantation and received basiliximab as part of acute rejection prevention. Both cases have a similar timeline of symptom onset, and both patients quickly developed severe respiratory failure requiring extracorporeal membrane oxygenation (ECMO) for respiratory support. Analysis of possible causes of respiratory failure points to a common medication that was administered to both patients. This report adds to a growing number of cases that suggest basiliximab may play a role in the development of respiratory failure in young patients undergoing renal transplantation surgery.
The Impact of Hand Edema on Weaning From Mechanical Ventilation in ICU Patients: A Single Center Nested Case‐Control Study
Authors: Wu Dingye , Heng Junfeng , Liang Fengming , Zhou Tao , Wang Qiuhui , Xu Hongyang
Published: February 2025

Objective: To investigate the impact of hand edema on weaning from mechanical ventilation among ICU patients.

Methods: A nested case‐control study was conducted, collecting data from mechanically ventilated patients admitted to the ICU of Wuxi People’s Hospital from October 1, 2023, to January 31, 2024. Patients were monitored for the occurrence of hand edema within the first 7 days of ICU stay and their weaning outcomes were recorded to analyze the impact of hand edema on weaning success.

Results: The study included 124 patients, 97 successfully weaned while 27 failed. The failed weaning group had higher ages (70.8 ± 10.5 years), SOFA scores (17.7 ± 3.1), and levels of hand edema (Grade 0 in 6 patients, Grade 1 in 9, Grade 2 in 6, Grade 3 in 3, and Grade 4 in 3) compared with the successful weaning group (ages 61.1 ± 9.8 years, SOFA scores 14.3 ± 3.1, hand edema levels: Grade 0 in 78, Grade 1 in 15, Grade 2 in 3, Grade 3 in 1, and Grade 4 in 0). Multivariable binary logistic regression analysis indicated that the level of hand edema is an independent risk factor for weaning failure within 1 week in ICU patients on mechanical ventilation (OR = 3.209, 95% CI: 1.641–6.274, and p < 0.05).

Conclusion: The occurrence of hand edema in ICU patients on mechanical ventilation increases the risk of weaning failure.
Avocado Pulp: A Review of Nutritional Profile, Functional Attributes, Drying Techniques, and Avocado Pulp Products
Authors: Cheptoo Annet , Ebere Rebecca , Arimi Joshua
Published: February 2025

Avocados (Persea americana Mill.) are mainly consumed fresh, although processed avocado products have recently gained popularity, driven by health trends and the need for convenience. With the rise in global demand for healthy and convenient food options, there is a need for studies on the effect of drying on the nutritional and functional properties and the value‐added products obtained from avocado pulp. This article focuses on avocado fruit, highlighting the recent advancements in avocado pulp drying techniques such as freeze‐drying, solar, spray, microwave, refractance window drying, infrared, and hot air–assisted radiofrequency drying. The value‐added products from avocado pulp in the food industry and the potential of avocado pulp as a nutraceutical have been discussed in addition to the economic feasibility of the drying techniques. An electronic search was carried out using ScienceDirect, Google Scholar, and ResearchGate databases for studies published between 2019 and 2024. The literature search carried out using the keywords “avocado pulp powder” and “dried avocado pulp” generated 34 papers, of which five were repeated. Eight papers on the phytochemicals in avocado pulp and four on economic feasibility were also included in the study. Forty‐one papers were reviewed based on defined inclusion and exclusion criteria, providing a comprehensive overview of the existing literature on avocado pulp drying. The findings offer valuable insights and recommendations on avocado pulp drying for food scientists, processors, and researchers.
Semen Quality Measures in Hookah and Cigarette Smokers Compared to Nonsmokers
Authors: Hamadneh Jehan , Al-Zenati Aseel A. , Banihani Saleem A.
Published: February 2025

Background: The relationship between smoking and human health is a well‐researched and continuously evolving field. The impact of smoking on semen quality, and consequently on male fertility, has also been explored, though most studies have primarily focused on cigarette smoking rather than hookah smoking.

Objective: In this study, we aimed to investigate and compare the effects of hookah and cigarette smoking on semen parameters in a sample of Jordanian males.

Methods: A total of 558 participants were prospectively recruited, including 300 cigarette smokers, 95 hookah smokers, and 163 nonsmokers (control). Semen analysis was performed approximately 1 h after ejaculation following the World Health Organization guidelines (2021).

Results: Interestingly, semen volume was significantly decreased in hookah smokers (p = 0.0097) but not in cigarette smokers when compared to the control group. No significant differences were observed in semen volume, progressive sperm motility, total motility, sperm count, sperm morphology (p = 0.2714, p = 0.8752, p = 0.6671, p = 8614, and p = 0.9261, respectively), and sperm vitality between hookah and cigarette smokers. Furthermore, except for semen volume, these semen parameters were not statistically different in both tested groups when compared to the control group.

Conclusions: Hookah smokers demonstrated lower semen volume compared to the control group. Additionally, no significant differences were found in sperm count, percentage of sperm motility, normal forms of sperm, and sperm vitality between hookah and cigarette smokers or between these groups and the control group.
Table S6 from Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity
Authors: Nie Jianhua , Zhang Shuyuan , Guo Ying , Liu Caiqi , Shi Jiaqi , Wu Haotian , Na Ruisi , Liang Yingjian , Yu Shan , Quan Fei , Liu Kun , Li Mingwei , Zhou Meng , Zhao Ying , Li Xuehan , Luo Shengnan , Zhang Qian , Wang Guangyu , Zhang Yanqiao , Yao Yuanfei , Xiao Yun , Tai Sheng , Zheng Tongsen
Published: February 2025

List of signature genes expressed in BTC T cell clusters.
Figure S8 from Breast Cancer Subtype–Specific Organotropism Is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery
Authors: Jiang Wen-Jing , Zhou Tian-Hao , Huang Huan-Jing , Li Lin-Sen , Tan Hao , Zhang Rui , Wang Qing-Shan , Feng Yu-Mei
Published: February 2025

Supplementary Figure 8
Supplementary Tables 1-8 from HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
Authors: Turnham Rigney E. , Pitea Adriana , Jang Gwendolyn M. , Xu Zhong , Lim Huat Chye , Choi Alex L. , Von Dollen John , Levin Rebecca S. , Webber James T. , McCarthy Elizabeth , Hu Junjie , Li Xiaolei , Che Li , Singh Ananya , Yoon Alex , Chan Gary K.L. , Kelley Robin K. , Swaney Danielle L. , Zhang Wei , Bandyopadhyay Sourav , Theis Fabian J. , Eckhardt Manon , Chen Xin , Shokat Kevan M. , Ideker Trey , Krogan Nevan J. , Gordan John D.
Published: February 2025

Supporting tables for proteomics datasets
Supplementary Data Table 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
Authors: Castro Jennifer , Daniels Matthew H. , Brennan David , Johnston Brian , Gotur Deepali , Lee Young-Tae , Knockenhauer Kevin E. , Lu Chuang , Wu Jie , Nayak Sunaina , Collins Cindy , Bansal Rishabh , Buker Shane M. , Case April , Liu Julie , Yao Shihua , Sparling Brian A. , Sickmier E. Allen , Silver Serena J. , Blakemore Stephen J. , Boriack-Sjodin P. Ann , Duncan Kenneth W. , Ribich Scott , Copeland Robert A.
Published: February 2025

Supplementary Data Table 3
Supplementary Data Figure 7 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
Authors: Castro Jennifer , Daniels Matthew H. , Brennan David , Johnston Brian , Gotur Deepali , Lee Young-Tae , Knockenhauer Kevin E. , Lu Chuang , Wu Jie , Nayak Sunaina , Collins Cindy , Bansal Rishabh , Buker Shane M. , Case April , Liu Julie , Yao Shihua , Sparling Brian A. , Sickmier E. Allen , Silver Serena J. , Blakemore Stephen J. , Boriack-Sjodin P. Ann , Duncan Kenneth W. , Ribich Scott , Copeland Robert A.
Published: February 2025

Supplementary Data Figure 7
Supplementary Dataset 3 from Energy Stress–Induced circEPB41(2) Promotes Lipogenesis in Hepatocellular Carcinoma
Authors: Yang Yang , Luo Jingjing , Wang Zhongyu , Liu Kaiyue , Feng Keyi , Wang Fang , Mei Yide
Published: February 2025

Targeted lipidomics analysis in Control and circEPB41(2) knockdown cells
Supplementary Data Figure 5 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
Authors: Castro Jennifer , Daniels Matthew H. , Brennan David , Johnston Brian , Gotur Deepali , Lee Young-Tae , Knockenhauer Kevin E. , Lu Chuang , Wu Jie , Nayak Sunaina , Collins Cindy , Bansal Rishabh , Buker Shane M. , Case April , Liu Julie , Yao Shihua , Sparling Brian A. , Sickmier E. Allen , Silver Serena J. , Blakemore Stephen J. , Boriack-Sjodin P. Ann , Duncan Kenneth W. , Ribich Scott , Copeland Robert A.
Published: February 2025

Supplementary Data Figure 5
Supplementary Data Figure 1 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
Authors: Castro Jennifer , Daniels Matthew H. , Brennan David , Johnston Brian , Gotur Deepali , Lee Young-Tae , Knockenhauer Kevin E. , Lu Chuang , Wu Jie , Nayak Sunaina , Collins Cindy , Bansal Rishabh , Buker Shane M. , Case April , Liu Julie , Yao Shihua , Sparling Brian A. , Sickmier E. Allen , Silver Serena J. , Blakemore Stephen J. , Boriack-Sjodin P. Ann , Duncan Kenneth W. , Ribich Scott , Copeland Robert A.
Published: February 2025

Supplementary Data Figure 1
Figure S13 from Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity
Authors: Nie Jianhua , Zhang Shuyuan , Guo Ying , Liu Caiqi , Shi Jiaqi , Wu Haotian , Na Ruisi , Liang Yingjian , Yu Shan , Quan Fei , Liu Kun , Li Mingwei , Zhou Meng , Zhao Ying , Li Xuehan , Luo Shengnan , Zhang Qian , Wang Guangyu , Zhang Yanqiao , Yao Yuanfei , Xiao Yun , Tai Sheng , Zheng Tongsen
Published: February 2025

The differentially expressed genes in GBC and pathway enrichment analysis.
Data from PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis
Authors: Zhou Zijian , Yin Xianyong , Sun Hao , Lu Jiaze , Li Yuming , Fan Yang , Lv Peiwen , Han Min , Wu Jing , Li Shengjie , Liu Zihao , Zhao Hongbo , Sun Haohan , Fan Hao , Wang Shan , Xin Tao
Published: February 2025

Abstract
Long-standing evidence implicates glioma stem cells (GSC) as the major driver for glioma propagation and recurrence. GSCs have a distinctive metabolic landscape characterized by elevated glycolysis. Lactate accumulation resulting from enhanced glycolytic activity can drive lysine lactylation to regulate protein functions, suggesting that elucidating the lactylation landscape in GSCs could provide insights into glioma biology. Herein, we have demonstrated that global lactylation was significantly elevated in GSCs compared with differentiated glioma cells. Polypyrimidine tract–binding protein 1 (PTBP1), a central regulator of RNA processing, was hyperlactylated in GSCs, and SIRT1 induced PTBP1 delactylation. PTBP1-K436 lactylation supported glioma progression and GSC maintenance. Mechanistically, K436 lactylation inhibited PTBP1 proteasomal degradation by attenuating the interaction with TRIM21. Moreover, PTBP1 lactylation enhanced RNA-binding capacity and facilitated PFKFB4 mRNA stabilization, which further increased glycolysis. Together, these findings uncovered a lactylation-mediated mechanism in GSCs driven by metabolic reprogramming that induces aberrant epigenetic modifications to further stimulate glycolysis, resulting in a vicious cycle to exacerbate tumorigenesis.

Significance: Glycolysis-induced lactylation enhances the function of PTBP1 to promote glioma stem cell maintenance, indicating that PTBP1 lactylation could be a potential target for the development of innovative glioma therapies.