bluuebunny/crossref_metadata_2025 huggingface dataset:
MATHEMATICAL MODELING OF CONCENTRATIONS OF GRAPE, POMEGRANATE AND BLACK CARROT JUICES BY VARIOUS METHODS
Authors: DİNÇER Cüneyt , ÇAM İhsan Burak , TORUN Mehmet , BAŞÜNAL GÜLMEZ Handan , TOPUZ Ayhan
Published: November 2019

In the present
study, grape, pomegranate and black carrot juices were concentrated to 65 °Brix
(Bx) from initial concentrations of 15.93, 13.91 and 11.23 °Bx respectively.
The concentration kinetics of the juices were investigated using a rotary
vacuum evaporator at 80°C, a microwave vacuum evaporator at 180 W and 300 W and
osmotic distillation (OD) at room temperature. Experimental data were compared
according to three statistical parameters: the correlation coefficient (R2),
reduced chi-squared (χ2) value, and root mean-square error (RMSE), with values
predicted by 13 models. Midilli model exhibited a better fit for the
concentration kinetics (R2 ≥ 0.9990; χ2 ≤ 0.4588; RMSE ≤
0.5350) than the other models, in general. This model was followed by the
logarithmic, Page and two-term exponential models. The logarithmic model
exhibited slightly better fitting for the thermal concentration method than
Midilli model. The lowest energy consumption (1.334-1.540 kWh) was determined
for the OD technique.
Persistent inflammation and endothelial dysfunction in patients with treated acromegaly
Authors: Wolters T L C , van der Heijden C D C C , van Leeuwen N , Hijmans-Kersten B T P , Netea M G , Smit J W A , Thijssen D H J , Hermus A R M M , Riksen N P , Netea-Maier R T
Published: November 2019

Objective

Acromegaly is characterized by an excess of growth hormone (GH) and insulin-like growth factor 1 (IGF1). Cardiovascular disease (CVD) risk factors are common in acromegaly and often persist after treatment. Both acute and long-lasting pro-inflammatory effects have been attributed to IGF1. Therefore, we hypothesized that inflammation persists in treated acromegaly and may contribute to CVD risk.

Methods

In this cross-sectional study, we assessed cardiovascular structure and function, and inflammatory parameters in treated acromegaly patients. Immune cell populations and inflammatory markers were assessed in peripheral blood from 71 treated acromegaly patients (with controlled or uncontrolled disease) and 41 matched controls. Whole blood (WB) was stimulated with Toll-like receptor ligands. In a subgroup of 21 controls and 33 patients with controlled disease, vascular ultrasound measurements were performed.

Results

Leukocyte counts were lower in patients with controlled acromegaly compared to patients with uncontrolled acromegaly and controls. Circulating IL18 concentrations were lower in patients; concentrations of other inflammatory mediators were comparable with controls. In stimulated WB, cytokine production was skewed toward inflammation in patients, most pronounced in those with uncontrolled disease. Vascular measurements in controlled patients showed endothelial dysfunction as indicated by a lower flow-mediated dilatation/nitroglycerine-mediated dilatation ratio. Surprisingly, pulse wave analysis and pulse wave velocity, both markers of endothelial dysfunction, were lower in patients, whereas intima-media thickness did not differ.

Conclusions

Despite treatment, acromegaly patients display persistent inflammatory changes and endothelial dysfunction, which may contribute to CVD risk and development of CVD.
Genetic investigation of patients with tall stature
Authors: Vasco de Albuquerque Albuquerque Edoarda , Ferreira de Assis Funari Mariana , Pereira de Souza Quedas Elisângela , Sayuri Honjo Kawahira Rachel , Soares Jallad Raquel , Homma Thaís Kataoka , Martin Regina Matsunaga , Brito Vinicius Nahime , Malaquias Alexsandra Christianne , Lerario Antonio Marcondes , Rosenberg Carla , Victorino Krepischi Ana Cristina , Ae Kim Chong , Arnhold Ivo Jorge Prado , Jorge Alexander Augusto de Lima
Published: November 2019

Context

Patients with tall stature often remain undiagnosed after clinical investigation and few studies have genetically assessed this group, most of them without a systematic approach.

Objective

To assess prospectively a group of individuals with tall stature, with and without syndromic features, and to establish a molecular diagnosis for their growth disorder.

Design

Screening by karyotype (n = 42), chromosome microarray analyses (CMA) (n = 16), MS-MLPA (n = 2) targeted panel (n = 12) and whole-exome sequencing (n = 31).

Patients and methods

We selected 42 patients with tall stature after exclusion of pathologies in GH/IGF1 axis and divided them into syndromic (n = 30) and non-syndromic (n = 12) subgroups.

Main outcome measures

Frequencies of pathogenic findings.

Results

We identified two patients with chromosomal abnormalities including SHOX trisomy by karyotype, one 9q22.3 microdeletion syndrome by CMA, two cases of Beckwith–Wiedemann syndrome by targeted MS-MLPA analysis and nine cases with heterozygous pathogenic or likely pathogenic genetic variants by multigene analysis techniques (FBN1 = 3, NSD1 = 2, NFIX = 1, SUZ12 = 1, CHD8 = 1, MC4R = 1). Three of 20 patients analyzed by WES had their diagnosis established. Only one non-syndromic patient had a definitive diagnosis. The sequential genetic assessment diagnosed 14 out of 42 (33.3%) tall patients.

Conclusion

A systematic molecular approach of patients with tall stature was able to identify the etiology in 13 out of 30 (43.3%) syndromic and 1 out of 12 (8.3%) non-syndromic patients, contributing to the genetic counseling and avoiding unfavorable outcomes in the syndromic subgroup.
WOMEN IN REPRODUCTIVE SCIENCE: Reproduction down under
Authors: Renfree Marilyn B
Published: November 2019

Australia is home to a unique assembly of mammals – the marsupials and monotremes. Despite this uniqueness, they have been largely ignored by the biomedical scientific community, and yet study of marsupials has contributed to modern research on reproduction, development, evolution, conservation, molecular and comparative genomics. My lifetime passion for these long-neglected Australian fauna has led to unexpected discoveries and insights that challenged assumptions and opened up new areas of international research. I used a range of disciplinary expertise to pursue the study of these unique mammals. My main experimental species has been the tammar wallaby that I have used as a model species to investigate and understand not only biomedical problems but also to provide knowledge that is critical for the continued conservation and management of Australia’s dwindling native mammals. This model provided more than a few surprises for me and my wonderful team of students, post-docs and collaborators about how hormones, genes and signalling molecules control reproductive biology and development in a wider context as well as how the interactions of the environment with mother and conceptus, with mother and fetus and mother and young ultimately control most aspects of successful reproduction in mammals.
Preimplantation development in ungulates: a ‘ménage à quatre’ scenario
Authors: Artus Jérôme , Hue Isabelle , Acloque Hervé
Published: November 2019

In ungulates, early embryonic development differs dramatically from that of mice and humans and is characterized by an extended period of pre- and peri-implantation development in utero. After hatching from the zona pellucida, the ungulate blastocyst will stay free in the uterus for many days before implanting within the uterine wall. During this protracted peri-implantation period, an intimate dialog between the embryo and the uterus is established through a complex series of paracrine signals. The blastocyst elongates, leading to extreme growth of extra-embryonic tissues, and at the same time, the inner cell mass moves up into the trophoblast and evolves into the embryonic disc, which is directly exposed to molecules present in the uterine fluids. In the peri-implantation period, uterine glands secrete a wide range of molecules, including enzymes, growth factors, adhesion proteins, cytokines, hormones, and nutrients like amino and fatty acids, which are collectively referred to as histotroph. The identification, role, and effects of these secretions on the biology of the conceptus are still being described; however, the studies that have been conducted to date have demonstrated that histotroph is essential for embryonic development and serves a critical function during the pre- and peri implantation periods. Here, we present an overview of current knowledge on the molecular dialogue among embryonic, extraembryonic, and maternal tissues prior to implantation. Taken together, the body of work described here demonstrates the extent to which this dialog enables the coordination of the development of the conceptus with respect to the establishment of embryonic and extra-embryonic tissues as well as in preparation for implantation.
Investigación de Ecoloxía Escolar nunha pradaría de Zostera nolteii
Authors: Sóñora Luna Francisco , Fernández Suárez Emilio , Barañano Carrión Carlota , Alonso Méndez Aitor
Published: November 2019

Analízase a situación da pradaría de Zostera nolteii do banco de marisqueo de bivalvos de Testal (Noia), mediante a investigación desenvolvida por escolares, coa dirección de científicos. A finalidade do programa de Ciencia Escolar de Climántica é contribuír ao coñecemento científico mediante a obtención de series de datos útiles para a realización de investigacións de interese a escala local. Neste caso, analizouse a relación existente entre as abundancias de bivalvos de interese comercial e a presenza da fanerógama Zostera nolteii co obxectivo de capacitar aos alumnos para facer ciencia sobre os impactos humanos sobre os servizos ecosistémicos máis relevantes da súa contorna. Con esta colaboración entre Ciencia e Escola, conseguiuse aumentar a competencia científica do alumnado, ao tempo que se realizaron transferencias bidireccionais ciencia – escola no eido da investigación e educación sobre o cambio global.A actividade que se describe neste traballo ten como obxectivo xeral coñecer a relación existente entre a diversidade de organismos animais do banco do Testal e a presenza e distribución espacial da fanerógama Zostera nolteii, para así entender o seu papel como xeradora de estructura no ecosistema intermareal de sustrato brando.
Respuestas educativas al cambio climático desde el Colegio Madrid: lecciones aprendidas y nuevos retos rumbo a Climántica México 2021
Authors: Catala Rosa Maria , Jiménez Aparicio Ana María , Rico Diener Ernesto
Published: November 2019

El Colegio Madrid de la Ciudad de México es un Colegio fundado por el exilio republicano español en el año1941, desde sus orígenes ha sido una institución con una clara vocación ambiental que ha seguido fiel a los principios naturalistas de la Escuela Libre de Enseñanza[1]. Próxima a cumplir ochenta años se mantiene a la vanguardia educativa a través de diversas acciones y participación en proyectos académico-culturales como la que se ha dado en el proyecto Climántica, uno de los de mayor repercusión e impacto en la última década. Paralelamente, el proyecto educativo de la institución evoluciona para responder a las nuevas necesidades de aprendizaje de los estudiantes a través de modelos innovadores de enseñanza, de programas interdisciplinarios y transcurriculares basados en la ética del cuidado y en el trabajo colaborativo. Coyunturalmente, como ciudad y país hemos resentido en los últimos años los efectos del cambio climático a través del incremento de la temperatura anual y la aparición de eventos meteorológicos extremos que nos han llevado a tomar medidas estructurales importantes. En este contexto cotidiano, el trabajo activo de la comunidad es clave para dar respuestas y soluciones a problemas reales a través de la conjugación de las tres dimensiones de la vida escolar: la organizacional, la académica y la cultural. Esta capacidad de adaptación nos está llevando a logros estratégicos basados en el desarrollo del pensamiento crítico, el pensamiento creativo, la comunicación y el ejercicio pleno de la ciudadanía de estudiantes y profesores. Un logro destacado reciente ha sido la co-organización con España y Costa Rica del primer campus Climántica Iberoamérica (San José, del 8 al 12 de abril de 2019), con resultados muy alentadores que dan paso ahora al reto de realizar el congreso virtual y campus Climántica México en 2021, en colaboración con la Universidad de Santiago de Compostela y otros socios estratégicos a nivel nacional e internacional, incluyendo a la Universidad de Aveiro, entre otros.[1] La Institución Libre de Enseñanza, inspirada por Francisco Giner de los Ríos, fue una de las corrientes pedagógicas que revolucionó la enseñanza entre finales del siglo XIX y principios del XX en España.
A PUF Hub Drives Self-Renewal inCaenorhabditis elegansGermline Stem Cells
Authors: Haupt Kimberly A , Law Kimberley T , Enright Amy L , Kanzler Charlotte R , Shin Heaji , Wickens Marvin , Kimble Judith
Published: November 2019

The Caenorhabditis elegans network for germline stem cells (GSCs) was missing key intrinsic regulators of self-renewal. Haupt et al. report that these missing regulators are PUF RNA-binding proteins, PUF-3 and PUF-11, which together with FBF-1 and FBF-2...

Stem cell regulation relies on extrinsic signaling from a niche plus intrinsic factors that respond and drive self-renewal within stem cells. A priori, loss of niche signaling and loss of the intrinsic self-renewal factors might be expected to have equivalent stem cell defects. Yet this simple prediction has not been borne out for most stem cells, including Caenorhabditis elegans germline stem cells (GSCs). The central regulators of C. elegans GSCs include extrinsically acting GLP-1/Notch signaling from the niche; intrinsically acting RNA-binding proteins in the PUF family, termed FBF-1 and FBF-2 (collectively FBF); and intrinsically acting PUF partner proteins that are direct Notch targets. Abrogation of either GLP-1/Notch signaling or its targets yields an earlier and more severe GSC defect than loss of FBF-1 and FBF-2, suggesting that additional intrinsic regulators must exist. Here, we report that those missing regulators are two additional PUF proteins, PUF-3 and PUF-11. Remarkably, an fbf-1  fbf-2; puf-3  puf-11 quadruple null mutant has a GSC defect virtually identical to that of a glp-1/Notch null mutant. PUF-3 and PUF-11 both affect GSC maintenance, both are expressed in GSCs, and epistasis experiments place them at the same position as FBF within the network. Therefore, action of PUF-3 and PUF-11 explains the milder GSC defect in fbf-1  fbf-2 mutants. We conclude that a “PUF hub,” comprising four PUF proteins and two PUF partners, constitutes the intrinsic self-renewal node of the C. elegans GSC RNA regulatory network. Discovery of this hub underscores the significance of PUF RNA-binding proteins as key regulators of stem cell maintenance.
On Copies MV 99 and NBKM 1043 – Representatives of a Special Type of the Expanded Edition of the Synaxarion
Authors: Chistyakova Marina
Published: November 2019

This article continues a series of research papers dedicated to the handwritten pieces of Church Slavonic heritage of the Grand Duchy of Lithuania and the Kingdom of Poland. It examines two synaxaria of Ukrainian origin of the 17th–18th centuries — NBKM 1043 and MV 99. In terms of the composition of the articles and their calendar timelines, they represent a special type created on the basis of the expanded edition of the Synaxarion, which is characterized by special versions of the lives of saints, traditional readings expanded with didactic insertions, and new sermons. The most striking features testifying to the kinship of the manuscripts NBKM 1043 and MV 99 are hagiographical parts identically shortened during the first half of the ecclesiastical year, the calendar distribution of readings that was changed in a similar way, and specific versions of the lives of saints combining two texts in honor of one saint. A comparative analysis showed that these synaxaria are characterized by some innovations in structure due to subsequent independent editing of copies of this type of the expanded edition. A series of 13 readings are incorporated in the structure of NBKM 1043, taken from the 3rd (Lithuanian) edition of the Emerald, whereas the MB 99 or its predecessor was episodically verified with a copy similar by its contents to the synaxarion BN 12185 III.
“Your Head so Dear to my Heart, I Would Hug Tight to My Chest and I would Tell How Much I Love You”. Letters of Jozefina Hálkova to Czesław Jankowski from 1884
Authors: Fedorovič Irena
Published: November 2019

The aim of the article is to analyze the three letters written in Czech in 1884 and addressed to Polish poet, writer, literature critic, and translator Czesław Jankowski (1857–1929). The author of the letters is a previously unknown Czech woman, the daughter of a schoolteacher in the city of Kladno. She got acquainted with Cz. Jankowski in Krakow and became the object of his passion. The letters are stored in the Wroblewski Library of the Lithuanian Academy of Sciences in Vilnius. Although the author of this article has already mentioned the existence of these love letters in 2000, J. Hálkova’s letters to Cz. Jankowski have not yet been analyzed.
Creative hope as a tool for social change
Authors: Масюк О. П.
Published: November 2019

This article is a socio-philosophical rethinking of an extraordinary approach to social hope creation. A newlook at the future is described as a messenger of a future social change. Creativity in designing the future is seenas going to the brink of the possible and impossible of social perspective transformation. As a result, the studyis based on a comprehensive analysis of social hope, which includes all aspects of creation and transformationof social space.The author reveals an understanding of the future existence through a convincing reflection of realityand a culture of perspective change. A designer can use constructive creativity when creating social hopes.Consequently, a dialog design becomes the basis for creative transformation of the present and future.The article analyzes the conflict between hard and soft infrastructure of the desired social space. This conflictis resolved by reflection of the design deviations’ safety in the future. The author approaches resolution of thecontradiction between creativity and organization in soft infrastructure. This process is based on supervisionitself. It is a socially acceptable way of creating social hope on individual level.The study describes a new level of dialogue between man and nature in creating social hope. The developmentof cyberbionics expands the horizons of vision and understanding of the future, which will give hope for a newquality of life in the future. This area of scientific research forms an innovative image of person of the future,and raises the question of its reliability, safety and humanity. The actual projection of the future denies man’s roleof being the author of his life. The visionaries of hope are oriented toward objectification of all the participantsin future social relations, except for themselves. Such project creativity is dangerous for the social world andrequires new measures to harmonize social relations.Creativity is a protest against existing phenomena in human life. A creative person offers his own versionof the future, which is opposite to the present. Consequently, creative hope can be seen as a manifestation ofanarchism, where each designer of the future has a part of his power over it. This ideology is transferred to thearrangement of the future social space. It is based on a harmonious combination of individual and collective witha creative approach to designing the future.
The influence of the ascriptive statuses at the intensity of students’ educational practices
Authors: Борисов Р. І. , Шеремет І. І.
Published: November 2019

The article deals with the influence of the Ukrainian students’ ascriptive statuses on the course of their professionalsocialization. There are are students’ status positions, educational dispositions and the content and focus of theeducational process among the factors of professional socialization. The ascriptive statuses are considered as socialindicators which may restrict the access of the students to the tertiary education. A number of ascriptive statuses,which may have the restrictive influence, are identified, among which are the sex, the economic and cultural capitalof the family, place of living before the admission to higher education. It was listed the signs of student heterogeneityas a socio-demographic group. The education of students in higher education institutions is considered with the prismof acquiring the competences obtained as a result of the implementation of educational practices. The professionalsocialization is considered as the process of the acquisition of the professional competences during the process of theimplementation of the educational practices. The notion of the professional practice is applied from the standpointof P. Bourdieu’s Constructivist Structuralism and is defined as routineized unconscious acts which are repeated intime and are aimed at the realization of the strategy of the achieving the goal within a certain sphere of social reality.The authors refer to the results of a quantitative survey of Ukrainian students to determine the degree of influence ofascriptive statuses on the process of professional socialization in universities. The relationship between the intensity ofeducational practices contributing to the learning process and academic achievement is analyzed. The existence andhierarchy of educational practices from the point of view of their effectiveness is identified and characterized. Theconclusion is made that there is a significant impact of the set of the students’ ascriptive statuses on the course of theprofessional socialization. As a result the cultural capital of a family of students has the highest “capital intensivity” incomparison with other ascriptive statuses.
Chaos in Heinrich Rickert’s Philosophy
Authors: Кулик О. В.
Published: November 2019

The purpose of this paper is to analyze what neo-Kantian Heinrich Rickert designates by the term‘chaos’. I argue that using this term Rickert means infinite manifolds of human life experiences, thatphilosophers have to convert into ‘cosmos’ of theories by using concept formation. Rickert thinks thatcognition orders chaos. I show that Rickert’s version of ‘chaos’ is different from the ones that were expressedby I. Kant, J. G. Herder, F. W. von Schelling, F. von Schlegel, and F. Nietzsche. I also argue that ideas ofI. Kant influenced the formation of Rickert’s ideas on chaos. Heinrich Rickert uses the term ‘chaos’ in hisepistemological theories that describe the process of cognition. Rickert claims that chaos is a raw materialfrom which a philosopher can form concepts for understanding the world and life. When creating concepts,the building blocks of theories, we order this chaos by dismembering it and marking essential relationships,separating them from non-essential ones. According to Rickert, ways of scientifically grasping reality suchas generalizing and individualizing help us dismember and order the ‘chaos’ of our experiences, creating a‘cosmos’ of theories. Rickert correlates the terms ‘cosmos’ and ‘form.’ He believes that philosophers haveto provide the idea of the clear distinction between form and content and have to see, in the same way,the distinction between cosmos and chaos. Philosophers, with their concepts, can give form to the chaosof experiences of the world and life, that is, they can create theoretical cosmos. Rickert states that only asystem of concepts can order chaos into cosmos. Concepts that are not part of a system cannot represent theworld as a whole. They represent only separate parts of the world, thus they cannot create a ‘cosmos’ as anordered whole. Therefore any philosophy must be formed by a system. Another important part of Rickert’sideas on chaos is his thought that ordering chaos has utility for a person. Through this activity we subduethe chaos of experiences of the world and life and it gives us the possibility of being oriented in reality andto gain mastery over it.
Avaliação de um curso para a capacitação dos profissionais da enfermagem na urgência e emergência
Authors: Sonnberger Thaisa Vieira , Marques Gustavo Lenci , Pinheiro Flavia Klas Blanski
Published: November 2019

AIMS: This work aims to evaluate a course model for the training of the nursing team in emergency care, as well as establishing the period which the knowledge acquired in the course is still memorized and when the course should be reministered to guarantee the professional’s proficiency.METHODS: We selected 45 nursing professionals who worked at the Cardiology Units of the Hospital de Clínicas of the Federal University of Paraná. In this group, a pre-test of 20 multiple choice questions was applied, mentioning the previous knowledge of the team. After the pre-test, a two-hour theoretical-practical course was given on the recognition of severe patients and initial management of a cardiorespiratory arrest, practicing ventilation maneuvers and chest compression on a manikin. After the course, the same test was reapplied to identify if there was improvement in the number of correct answers. Within three and six months the test was again applied in order to establish the knowledge storage rate over that period.RESULTS: We observed that the average accuracy in the pre-test was 9.4±3.3 questions. In the immediate post-test, there was an increase in the mean of correct answers to 15.3±2 questions. After three months, the average number of correct answers fell to 12±3.1 questions and after six months was 10±3.3 questions. It was also possible to identify that the professionals who worked in the Intensive Care Unit and Hemodynamics presented a greater number of correct answers (12.6±3.4) when compared to the professionals who worked in the Infirmary (9.4±4.4). Performing a regressive analysis, we observed a statistically significant improvement in the test results shortly after the training and in three months (p < 0.05) – which did not occur in the time of six months.CONCLUSION: We can infer from the improvement in the number of correct answers to the questionnaire that the theoretical-practical course model was effective in promoting the training of nursing professionals. However, the fixation of knowledge decays over the months, returning to values close to the initial within six months.
Common Sun Skink Eutropis multifasciata (Kuhl 1820) sold for Traditional Medicine in Indonesia and potential conservation implications.
Authors: Janssen Jordi , Gomez Lalita
Published: November 2019

Reptiles are one of the most frequently encountered animal species in the trade for traditional medicine. The use of reptiles for medicinal purposes has been documented throughout the world, impacting dozens of species. Despite the broad occurrence of reptiles in medicinal trade, there is a general lack of information concerning the scale or impact of this trade and the species involved. Here we report the sale of Common Sun Skinks Eutropis multifasciata on the island of Java in Indonesia. We surveyed 13 wildlife markets and three reptile pet stores in eight cities across Java, documenting 110 Common Sun Skinks in trade in six markets in five cities. This skink is sold for traditional medicinal purposes with several vendors stating its use to treat skin problems like “itchiness”. This particular use has not been well documented in Indonesia. Further, the Common Sun Skinks were primarily sold by vendors selling Tokay Geckos for a similar purpose. This is of potential conservation concern as Tokay Geckos are harvested en masse for medicinal purposes which has resulted in significant population declines, and this could lead to potential over¬exploitation of the Common Sun Skink in response to this decline.
Modelo teórico socio-ambiental para la gestión estratégica del turismo sustentable en el complejo hidroeléctrico Uribante-Caparo de los estados Táchira y Mérida Venezuela
Authors: Sosa Nelson José
Published: November 2019

La falta de gestión y planificación estratégica de actividades turísticas ha traído como consecuencia que no se pueda desarrollar un turismo sustentable. Estas razones motivaron la creación de un Modelo Teórico Socio-Ambiental para la Gestión Estratégica del Turismo Sustentable en el Complejo Hidroeléctrico Uribante-Caparo (CHUC) de los Estados Táchira y Mérida (Venezuela). La investigación fue cualitativa al utilizar el método etnográfico, enmarcado en el paradigma interpretativo. Se realizó un diagnóstico a través de entrevistas a profundidad a seis informantes claves (2) gerentes del CHUC, (1) Superintendente del Parque Nacional Tapo-Caparo; (3) alcaldes de los Municipios Uribante, Libertador y Santa María de Caparo-Mérida; 5 miembros de la comunidad: Siberia (1) Pregonero (3) y Santa María de Caparo (1), incluyendo miembros del Consejo Comunal. El investigador registró 15 notas de campo de las observaciones realizadas en los diferentes momentos del estudio. Los hallazgos más resaltantes fueron: Existencia de numerosas bellezas naturales como potencial turístico, la población tiene tradiciones culturales, el CHUC tiene una infraestructura y embalses que constituyen un atractivo turístico internacional, el potencial natural y social que tiene la región se proyecta como un potencial permanente para el turismo sustentable. El Modelo propuesto relaciona: a) La cultura turística y el ecoturismo; b) El turismo sustentable y una cultura turística sustentable; c) El turismo y la gestión turística; y d) La gestión turística y el ecoturismo, para lograr calidad de vida, conservación integral de recursos, unificación económica del medio ambiente e integración comunitaria.
El conocimiento didáctico del contenido (cdc) de los docentes de la cátedra de proyectos en la carrera de arquitectura de la UNET
Authors: Contreras Astrid , Salazar Luis
Published: November 2019

El propósito de esta investigación no es desacreditar la labor que tradicionalmente se ha estado desarrollando por parte de los docentes arquitectos de proyectos; por el contrario, se pretende divulgar cómo es el conocimiento didáctico del contenido (CDC) de este profesional de la Universidad Nacional Experimental del Táchira (UNET), ubicada en la ciudad de San Cristóbal, Venezuela. El CDC en los profesionales técnicos es de gran importancia en su práctica académica, en este caso el docente arquitecto tiene la responsabilidad de transmitir a través de herramientas didácticas los lineamientos básicos-creativos para la formación integradora de elementos que generen un producto, acercándose a la realidad. Se plantearon como objetivos: identificar los fundamentos teóricos acerca del conocimiento didáctico, determinar las estrategias didácticas empleadas por los docentes arquitectos de la UNET en la asignatura de proyectos, describir el conocimiento del contenido didáctico actual del profesor de proyectos, y sintetizar desde el punto de vista del proceso de enseñanza y aprendizaje las posibles soluciones a implementar por los docentes de arquitectura en la cátedra de proyectos. Dentro de la metodología empleada se destaca el paradigma cualitativo con enfoque etnometodológico, el cual permitió evaluar cómo es el comportamiento de este especialista docente dentro del aula de clase; considerando como escenario el Taller de Diseño y seleccionando una muestra intencional de 07 docentes y 34 estudiantes pertenecientes a los 2 últimos semestres de Proyectos VII y VIII de la Carrera de Arquitectura. Se emplearon técnicas de recolección de información, como la encuesta y la observación, acompañados del cuestionario con preguntas abiertas y cerradas enmarcadas en las categorías pedagogía, academia y didáctica; los elementos premeditados por parte de los investigadores permitieron información valiosa para definir el CDC del profesional en estudio. El análisis de los datos fue a través del SPSS con la finalidad de categorizar e identificar puntos en común de la información obtenida. Los hallazgos obtenidos revelaron una deficiencia en cuanto al CDC y la aplicación de estrategias de enseñanza en el desarrollo de la asignatura de proyectos.
Multivariate analysis of the megacity population immunity to measles
Authors: Semenenko Tatiana A. , Nozdracheva Anna V. , Asatryan Marina N. , Akimkin Vasilij G. , Tutelyan Aleksey V. , Shmyr Ilia S. , Ershov Ivan F.
Published: November 2019

Background: The significant reduction of measles and rubella morbidity and child mortality, which allowed WHO to set a target for their elimination by 2010, is one of the finest examples of the vaccine prevention effectiveness in the fight against infectious diseases. However, in the period from 2010 to 2019 there was a controversial situation with respect to measles, characterized by the presence of high vaccination coverage of the population on the one hand, and an increase in the incidence on the other. Obviously, the key point in resolving these contradictions is to analyze the susceptibility of the population.
Aim: Of the study was to assess the susceptibility of Moscow population to measles in the context of factors affecting its formationю.
Methods: Epidemiological, serological, statistical methods and GIS technologies were used in the work. The serological study (using the solid-phase ELISA method) included 2410 blood serum samples collected between 2013 and 2017 from healthy residents of Moscow aged from birth to 60 years. On the basis of documents on sanitary and epidemic investigation of measles cases in Moscow (20132015) a relational database under the management of MySQL Database Management System was formed, based on the analysis of which the coverage of the population with preventive vaccinations was estimated.
Results: Оn average, the proportion of seronegative persons to measles in 20162017, compared with 20132014 (20.5%) increased and amounted to 29.0% mainly due to the group over 36 years. The most vulnerable were children aged 12 years and 36 years, where the share of the immune persons amounted to 51,5% and 37.9%, respectively, at low coverage in a planned manner (55,9% [95% CI, 52.2 per cent; of 59.5%] and 75,3% [95% CI, 73.3 per cent; for 77.2%]). The proportion of vaccinated persons who lost post-vaccination immunity under the influence of factors preventing its formation (from 3.6% to 21.6% in the group of 714 years; from 11.8% to 26.4% in the group of 1517 years) was calculated. The possibility of visualizing the spread of measles on electronic maps for the territorial and temporal analysis of the epidemic situation is shown.
Conclusions: It is reasonable to assume that over the time, the proportion of people who have suffered measles will decrease, and the proportion of people not covered by vaccination or lost post-vaccination immunity - increase, that can lead to a decrease in herd immunity and requires correction of vaccination work. The proposed information and analytical system for monitoring the epidemiological situation allows to work quickly with heterogeneous resources and choose on electronic maps the area of interest from the global level (country) to the local (house), which is necessary for the adoption of scientifically based preventive and epidemiological measures.
Heart involvement in AL-amyloidosis. Current state of the issue
Authors: Trukhin Ivan V. , Schekochikhin Dmitrij Yu. , Novikova Nina A. , Akselrod Anna S. , Syrkin Abram L. , Syrkina Helena A. , Grachev Alexander E. , Gribanova Helena O. , Okhota Valeria K. , Ryzhko Vyacheslav V. , Pershina Ekaterina S.
Published: November 2019

AL cardiac amyloidosis is a relatively rare disorder that belongs to the group of infiltrative cardiomyopathies. Diagnosis of primary amyloidosis is challenging due to many unspecific symptoms and sings, which often leads to late diagnosis when treatment options are limited. Primary amyloidosis particularly needs to be excluded in patients with heart failure with preserved ejection fraction. Therapy in cardiac amyloidosis has to main vectors: 1) chemotherapy to eliminate amyloidogenic plasmatic cells 2) heart failure treatment. The main challenge for cardiologists is to support hemodynamics until response to chemotherapy occurs. In the article the issue of diagnostics, risk stratification and treatment of primary cardiac amyloidosis is addressed.
Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants
Authors: Sychev Dmitry A. , Sychev Igor N. , Mirzaev Karin B. , Rytkin Eric I. , Ivashchenko Dmitriy V. , Bure Irina V. , Otdelenov Vitaliy A.
Published: November 2019

One of the main causes for adverse reactions development is not taking into account the pharmacokinetics of drugs and the dose. Pharmacokinetics of drugs is mostly defined by the cytochrome P-450 isoenzymes activity, carboxylesterases and many other isoenzymes of drug metabolism, as well as ADME transporters (P-gp etc.) which take part in the process of drug metabolism. The activity of these isoenzymes is defined by the genetic aspects of patients and non-genetic aspects such as comorbidity and drug-drug interactions. The development of complex algorithms for personalization of therapy based on the results of pharmacogenetic studies and in the form of a decision support system will play an important role in reduction of adverse drug reactions. A lot can be achieved for personalization of Direct Oral Anticoagulants for treatment of cardiovascular diseases. New approaches are being developed based on the results of pharmacogenetic and pharmacokinetic testing that will help diminish adverse effects of drugs.
Pengaruh Lantunan Ayat Al-Quran terhadap Kebutuhan Opioid Tambahan Pascaseksio Sesarea
Authors: Winasty Silvi , Indriasari Indriasari , Kestriani Nurita Dian
Published: November 2019

Lantunan ayat Al-Quran dapat menstimulasi β endorfin yang dihasilkan hipofisis anterior otak. Penelitian ini bertujuan mengetahui pengaruh  lantunan ayat Al-Quran terhadap intensitas nyeri dan kebutuhan opioid tambahan pascaseksio sesarea dengan regional spinal. Metode penelitian adalah eksperimental  secara acak terkontrol buta tunggal pada 32 ibu hamil berusia >18 tahun dan beragama islam di RSUP Dr. Hasan Sadikin Bandung pada bulan April–Mei 2019. Data jumlah penggunaan opioid tambahan pascaoperasi  selama 24 jam yang diberikan dengan patient controlled analgesia (PCA) dianalisis dengan Uji Mann-Whitney. Hasil perhitungan statistik diperoleh penggunaan opioid tambahan pada kelompok lantunan Al-Quran lebih sedikit  dibanding dengan kelompok kontrol  (21,87 mcg vs 107,87 mcg) dengan perbedaan yang sangat bermakna (p<0,0001). Simpulan penelitian ini menunjukkan bahwa lantunan ayat Al-Quran sebagai terapi tambahan penatalaksanaan nyeri pascaseksio sesarea menurunkan  penggunaan opioid tambahan.Effect of Quran Recital on Additional Opioid Requirement in Post-Cesarean SectionThe recitation of Al-Quran could stimulate β endorfins which is produced by anterior pituitary. This study aimed to identify the effect of listening to Al-Quran recitation on pain intensity and additional opioid requirement in patients after spinal cesarean section surgery. This was a randomized single blind controlled experiment on 32 pregnant moslem women over 18 years old treated in Dr. Hasan Sadikin General Hospital Bandung in April 2019-May 2019. The amount of additional 24-hours post-operative opioid requirement using Patient Controlled Analgesia (PCA) was analyzed by the Mann-Whitney Test. Results showed that the use of additional fentanyl in the Al-Quran recitation group was significantly less than in the controlled group(21.87 mcg vs 107.87 mcg) (p<0.0001). Therefore, Al-Quran recitation as an additional therapy in the management of pain is able to reduce the dose of additional fentamyl needed in postcaesarean section patients.
Laporan Kasus: Anestesi Blok Peribulbar pada Pasien dengan Gagal Jantung Kongestif yang Dilakukan Enukleasi
Authors: Adli Muhamad , Wullur Caroline
Published: November 2019

Seorang pria berusia 73 tahun datang ke Instalasi Gawat Darurat Pusat Mata Nasional Rumah Sakit Mata Cicendo pada bulan November 2018 dengan keluhan nyeri mata yang mengeluarkan darah dan disertai dengan keluhan sesak. Pemeriksaan mata menunjukkan prolaps okuli dan direncanakan untuk dilakukan enukleasi. Ahli kardiologi mendiagnosis sebagai hypertensive heart disease, congestive heart failure functional class IV, moderate mitral regurgitation, moderate aortic regurgitation. Laporan kasus ini bertujuan memaparkan keberhasilan tata laksana anestesi pada pasien usia lanjut dengan gagal jantung kongestif yang dilakukan enukleasi dalam blok peribulbar. Teknik blok peribulbar dipilih agar tidak memperberat masalah kardiovaskular serta untuk meminimalisir depresi kardiak. Teknik ini dilakukan dengan menyuntikkan obat anestesi lokal levobupivakain 0,5% pada inferotemporal, medial kantus, dan superonasal. Operasi berlangsung tanpa keluhan nyeri dan fluktuasi hemodinamik yang signifikan. Pascaoperasi pasien sadar penuh dengan skala nyeri NRS 60 menit pascaoperasi 0. Hal ini menunjukkan bahwa teknik anestesi blok peribulbar memberikan hasil memuaskan pada tindakan enukleasi. Enucleation under Peribulbar Block Anesthesia in Patients with Congestive Heart Failure: A Case ReportA 73-year-old male patient was presented to the emergency department of the National Eye Center Cicendo Hospital with a painful and bloody eye as well as shortness of breath. Eye examination revealed ocular prolapse and patient was scheduled for enucleation. The cardiologist diagnosed the patient with hypertensive heart disease, congestive heart failure functional class IV, moderate mitral regurgitation, and moderate aortic regurgitation. Patient then underwent treatment for six days. This case report aimed to describe the successful management of anesthesia in elderly patients with congestive heart failure who underwent peribulbar block for enucleation procedure. To prevent further cardiac problems and to minimize the risk of cardiac depression in this patient, the anesthetic technique chosen was peribulbar block with the injection of local anesthetic drug levobupivacaine 0.5% at the inferotemporal, medial canthus, and superonasal. The surgary took place without complaints of intraoperative pain and without significant hemodynamic fluctuations. Postoperatively, the patient was fully conscious and sixty minutes postoperative pain scale (Numeric Rating Scale) in this patient was 0. This shows that the peribulbar block anesthesia technique can provide satisfactory results for enucleation procedure.
A Study on Zooplankton Fauna and Some Water Quality Parameters of Kozan Dam Lake (Adana, Turkey)
Authors: TUĞYAN Cem , BOZKURT Ahmet
Published: November 2019

Some water quality parameters (Secchi disk depth, water temperature, dissolved oxygen, pH, conductivity, chlorophyll a, NO2-N, NO3-N, NH4-N, PO4-P) and zooplankton fauna were determined in the Kozan Dam Lake. While the quality of the reservoir water was first class water in terms of temperature, dissolved oxygen, NH4-N, PO4-P, it was second-class water in terms of conductivity, pH, NO3-N. In total, 50 zooplankton species belonging to 26 families were determined (29 species belonging to 17 families from Rotifera, 15 species belonging to 7 families from Cladocera and 6 species belonging to 2 families from Copepoda). Brachionidae (Rotifera) was the most species rich family with 7 species, followed by Chydoridae (Cladocera) and Cyclopidae (Copepoda) with 6 and 5 species respectively. The most dominant species were Synchaeta pectinata (38.33%) from Rotifera, Bosmina longirostris (5.71%) from Cladocera and Cyclops vicinus (0.67%) from Copepoda. At the same time, the species found in every month were Asplanchna priodonta, Polyarthra dolichoptera, Bosmina longirostris, Ceriodaphnia pulchella, Cyclops vicinus and Diacyclops bicuspidatus. In the study, Rotifera was the most abundant group with 67%, followed by Cladocera with 29% and Copepoda with 4%. On the other hand, total Rotifera was found mostly in December (10099 individual/ m3), Cladocera in January (4928 ind./m3) and Copepoda in September (1091 ind./m3).
ВЛИЯНИЕ ФЛАГМАНСКИХ ПРЕДПРИЯТИЙ, ПРЕДПРИНИМАТЕЛЬСКОЙ ДИНАМИКИ И УРОВНЯ КОНЦЕНТРАЦИИ ТЕРРИТОРИАЛЬНОЙ ЭКОНОМИКИ НА ЗАКРЫТИЕ КОМПАНИЙ: ЭКОНОМЕТРИЧЕСКИЙ АНАЛИЗ
Authors: Анохин Сергей Александрович , Спицына Любовь Юрьевна , Спицын Владислав Владимирович
Published: November 2019

Цель: в статье рассматривается прямое и опосредованное влияние флагманских предприятий, стартапов, а также степени концентрации территориальной экономики на темпы ликвидации территориальных предприятий. Обсуждение: авторы выдвигают предположение, что наличие флагманских предприятий, а также высокие темпы создания стартапов на территории приводят к повышению уровня ликвидации территориальных предприятий. В то же время высокие уровни концентрации территориальных предприятий замедляют ликвидацию предприятий. Предполагается, что данные процессы особенно интенсивны, если территориальная экономика характеризуется высокими уровнями доходов населения. Результаты: в ходе анализа панельных данных 86 муниципальных образований в трех регионах Российской Федерации подтверждена положительная роль флагманских предприятий и стартапов в темпах ликвидации территориальных предприятий, а также отрицательный эффект территориальной концентрации на темпы ликвидации. Эффекты флагманских предприятий особенно сильны при высоком уровне доходов населения на территории, а стартапов – при низком уровне дохода.
ИССЛЕДОВАНИЕ ИНДУСТРИАЛЬНОЙ БАЗЫ ИННОВАЦИОННОГО РАЗВИТИЯ РОССИЙСКОЙ ЭКОНОМИКИ
Authors: Ряпухина Виктория Николаевна
Published: November 2019

Цель: статья посвящена исследованию характера и степени связи между уровнем индустриализации и инновационной результативностью регионального развития. Обсуждение: в предположении, что инновационное развитие региональных экономик должно основываться на устойчивой индустриальной базе, авторы предлагают осуществить анализ степени готовности промышленности обеспечить инновационный прорыв в рамках четвертой промышленной революции. Результаты: авторами предложены модели инновационного развития российских регионов, а также исследована степень детерминированности промышленного развития инновационной результативностью. Результаты проведенных эмпирических исследований подтвердили невозможность перевода национальной экономики на инновационные «рельсы» без повышения уровня ее индустриализации на новом технологическом уровне.
Conhecimento e atuação dos profissionais da farmácia sobre a dispensação dos medicamentos
Authors: Freire Izaura Luzia Silvério , Santos Fernanda Rafaela dos , Barbosa Juliana Dos Santos , Silva Bárbara Coeli Oliveira da , Silva Iago Souza da , Freitas Anna Alice Lessa de
Published: November 2019

Introdução: A dispensação de medicamentos corresponde a entrega de medicação ao paciente, mediante solicitação por meio da prescrição. Uma dispensação adequada colabora com a segurança na terapia medicamentosa. Objetivo: Descrever o conhecimento e a atuação dos profissionais da farmácia sobre a dispensação dos medicamentos. Métodos: Trata-se de estudo exploratório-descritivo, transversal e quantitativo, realizado em uma maternidade escola na Região Nordeste do Brasil, com 25 profissionais da farmácia. Resultados: A maioria dos participantes informou que a farmácia estudada utiliza o sistema misto de distribuição dos medicamentos (96,0%), não possui programa informatizado para a dispensação de medicamentos (52,0%), o ambiente de trabalho se encontra inadequado (84,0%), presenciaram (68,0%) ou cometeram (52,0%) erros relativos a dispensação, nunca realizam a dupla checagem (72,0%), sempre identificam e diferenciam o estoque de medicamentos potencialmente perigosos dos demais (80,0%), nunca utilizam fontes de distrações durante a análise e dispensação dos medicamentos (56,0%) e algumas vezes dispensam medicamentos por ordem verbal (60,0%). Conclusão: Verificou-se a necessidade de se modificar a prática da farmácia estudada por meio de educação permanente e implementação de estratégias que minimizem a ocorrência de erros.

Palavras-Chave: Conhecimento; Preparações Farmacêuticas; Farmácia.