bluuebunny/crossref_metadata_2025 huggingface dataset:
История русской литературы конца XIX – начала XX века : учебное пособие для студентов-филологов, обучающихся по направлению 44.03.01 – «Филология» (профиль «Педагогическое образование»)
Authors:   Саратовский государственный университет, Мокина Н. В. , Минц Б. А. ,   Саратовский государственный университет
Published: October 2022

Учебное пособие «История русской литературы конца XIX – начала ХХ века» содержит тексты лекций, планы практических занятий и материалы для анализа художественных текстов – произведений Л. Н. Андреева, А. И. Куприна, Е. Замятина, И. Шмелева и др. В лекциях рассматриваются ключевые аспекты, связанные с изучением как литературного процесса конца XIX – начала ХХ века (проблемы литературных направлений, их специфики, «состава»), так и творческого пути наиболее значительных прозаиков и поэтов эпохи. Для студентов-филологов, обучающихся по направлению 44.03.01 «Филология» (профиль «Педагогическое образование»).
Hernia ventral incisional, resolución laparoscópica mediante técnica IPOM-plus. Reporte de caso
Authors: Sarmiento Beltrán Paúl Alejandro , Tuapante Quintuña Paúl Adrián , Pesántez Brito Ismael Francisco
Published: October 2022

Introducción: una hernia incisional constituye una protrusión anormal del peritoneo a través de la cicatriz patológica de una herida quirúrgica o traumática, cuya frecuencia oscila entre el 12% al 15% de todas las laparotomías efectuadas.
Caso clínico: paciente obesa de 55 años con una hernia incisional de gran tamaño de dos años de evolución que acude al servicio de consulta externa del Hospital Básico de Paute. Entre sus antecedentes se destaca la presencia de Linfoma no Hodgkin hace 11 años. La tomografía de abdomen evidencia una voluminosa hernia incisional en pared abdominal anterior con anillo herniario de aproximadamente 10 cm por donde protruye epiplón y contenido de asas intestinales sin signos de incarceración. Se procede a reparación del defecto herniario vía laparoscópica mediante la técnica IPOM-plus (Intra Peritoneal Onlay Mesh - plus). La paciente permaneció hospitalizada por 48 horas luego de lo cual fue dada de alta en buenas condiciones.
Conclusión: la técnica IPOM-plus es una excelente alternativa en pacientes con hernias incisionales y ventrales ya que generan mínimo sangrado, corta estancia hospitalaria y escaso uso de antibióticos, por ello se reafirma la importancia clínica de este informe.
Factores clínicos gastrointestinales como expresión fenotípica de COVID-19. Revisión bibliográfica.
Authors: Fernández Collahuazo Cristina Nataly , Idrovo Macancela Mayra Estefanía , Torres Arévalo Janina Tatiana , Encalada Torres Lorena Esperanza
Published: October 2022

Introducción: la aparición del nuevo SARS-CoV-2 y su rápida propagación plantea una emergencia sanitaria mundial. Este virus afecta principalmente al sistema respiratorio, aunque también al tracto gastrointestinal.

Objetivo: identificar si las manifestaciones gastrointestinales secundarias a la infección por Covid-19 son una expresión fenotípica e importante de esta patología.

Metodología: se realizó una búsqueda sistemática en revistas médicas científicas en las bases de datos: Scielo, PubMed, SpringerLink, Wile Online Library, Scopus con los siguientes términos “Manifestaciones Gastrointestinales por COVID-19”, “Síntomas gastrointestinales por SARS-COV2”, “Alteraciones gastrointestinales en COVID-19”, publicados en inglés y español entre el año 2020 y 2021.

Resultados: síntomas gastrointestinales más prevalentes fueron diarrea, náuseas, vómito, anorexia y dolor abdominal. La fisiopatología de las manifestaciones gastrointestinales depende de la enzima convertidora de angiotensina 2 (ACE2) y la serina proteasa 2 transmembrana (TMPRSS2). La detección de ARN viral en heces como diagnóstico se ha detectado en el 53,4% de pacientes infectados, otros métodos descritos no son definitorios. Finalmente, el tratamiento de las manifestaciones gastrointestinales por COVID-19 es sintomático.

Conclusiones: los avances sobre epidemiología, patogénesis, características clínicas, medios de diagnóstico y tratamiento del COVID-19, evidencian que las manifestaciones gastrointestinales secundarias se presentan de forma y frecuencia variable, permitiendo enfrentarse al COVID-19 epidémico de manera más efectiva.
Corrección del morfema OMO en la terminología anatómica. Revisión bibliográfica
Authors: Machado Orellana Maria Gabriela , Cuji Galarza Wendy Dayanna
Published: October 2022

Introducción: la Terminología Anatómica Internacional (TAI) ha compilado y estandarizado los términos anatómicos para su uso unívoco, pero en ocasiones estas normas no se cumplen totalmente. Entre las inconsistencias existentes está el uso de “escápula” u “omóplato”.
Objetivo: analizar los términos en los cuales ha sido utilizado erróneamente el morfema “omo”, y sugerir la terminología adecuada.
Metodología: se buscó en la TAI las palabras que contienen el morfema “omo”. Y se indagó el significado de “escápula” y “omóplato” en diccionarios de latín, griego, y diccionarios médicos.
Resultados: los términos “scapula”, del latín, y “omóplato”, del griego, se traducen al español como ‘hombro’. En los diccionarios médicos españoles, “escápula” se define etimológicamente como ‘parte alta de la espalda’; y “omóplato”, como ‘parte plana del hombro’. En la TAI se identificaron: M. omohioideo, triángulo omoclavicular, triángulo omotraqueal y ganglio yugulo-omohioideo.
Discusión: el término anatómico correcto es “escápula”. El músculo omohioideo debería denominarse “escapulohioideo”; el triángulo omoclavicular, “triángulo supraclavicular”; el triángulo omotraqueal, “triángulo muscular anterior del cuello”; y el ganglio yugulo-omohioideo, “ganglio yugulo-escapulohioideo”. Las correcciones aplican para el idioma español.
Conclusiones: para unificar la terminología, las estructuras anatómicas que llevan el morfema “omo”, de origen griego deberían usar el prefijo latino “escapulo”, o emplear una terminología descriptiva sobre su posición anatómica.
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Gas flow multilevel mathematical model in the nozzle channel with a central body
Authors: Kaun Yu.V. , Brykov N.A.
Published: October 2022

Supersonic non-isobaric jet outflow was studied under conditions of interaction with the slipstream. Multilevel mathematical model was compiled making it possible to analyze structure of the gas-dynamic flow in the vicinity of the nozzle channel central body at the aircraft take-off path (0...10 km). Multilevel approach to calculating thrust parameters of the nozzle channel with central body requires development of a physical and mathematical model of the non-stationary interdependent processes that characterize operation of the “aircraft – nozzle cluster – jet” system as a whole. At the same time, it is necessary to form mathematical models of the processes for different degrees of the task detailing, i.e. within each scale of the task (micro-, meso- and macro-scale). Mathematical model includes calculation of the aircraft traction characteristics, study of the interaction features between the jet, the central body and the slipstream.
Rozwój rolnictwa ekologicznego w Polsce na przestrzeni lat 2011–2020
Authors: Jarecki Wacław
Published: October 2022

W pracy przedstawiono stan i rozwój rolnictwa ekologicznego w Polsce i poszczególnych województwach. Wykazano, że na przestrzeni lat 2011–2020 liczba ekologicznych producentów oraz powierzchnia ekologicznych upraw uległy zmniejszeniu. Odnotowana dynamika zmian była zróżnicowana w zależności od analizowanego województwa. Największą i stabilną liczbą producentów ekologicznych odznaczyło się województwo warmińsko-mazurskie. W badanych latach wzrosła liczba producentów zajmujących się przetwórstwem produktów ekologicznych oraz produkcją pasz i/lub drożdży. Wzrost liczby analizowanych przetwórców dotyczył każdego z województw, a największy odnotowano w mazowieckim i wielkopolskim. Łączna powierzchnia ekologicznych użytków rolnych (w okresie i po konwersji) istotnie zmniejszyła się. Największe spadki ekologicznych zasiewów wykazano w województwie zachodniopomorskim i podkarpackim.
Życie z dala od miasta. O popularności serii dokumentalnej Daleko od miasta
Authors: Zdrowicka-Wawrzyniak Magdalena
Published: October 2022

Artykuł traktuje o popularności programu telewizyjnego Daleko od miasta, w którym przedstawia się „mieszczuchów”, którzy zdecydowali się przeprowadzić na wieś. Gospodyni programu odwiedza ludzi, którzy postanowili zmienić swoje życie i na rozmaite sposoby realizują się zawodowo z dala od miasta. Za sprawą ich niebanalnych pomysłów na życie zamieszkane gospodarstwa zyskały nowego blasku. Program dowodzi, że polskiej wsi nie powinniśmy już definiować jedynie poprzez jej agrarność i rolniczość, jak również, że wieś jest współcześnie dobrym kierunkiem migracji.
Developing a mobile application to facilitate online shopping
Authors: Salama Ramiz , Anam Ibrahim
Published: October 2022

Shopping is a popular pastime for many individuals and the same is true with online buying. However, when it comes to online shopping, people are often restricted since most online shopping websites and apps lack certain features that facilitate the process. The goal of this initiative is to develop a web-based user-friendly interface for online consumers with system simplicity that would increase consumers' enjoyment of shopping. This online shopping web application is to address this problem by enabling users to experiment with the search tool, create various combinatorial search criteria to conduct a thorough search and provide an interactive interface that enables users to quickly interact with different application features. Based on the search term, the search engine would present a list of items, which the user could then filter based on several criteria.
 
Keywords: Mobile application, online, privacy, shopping, shopping guide;
PROTOTYPE OF VACUUM FRYING OYSTER MUSHROOM CHIPS
Authors: Nabillah Anisa , Yuliati Selastia , Zamhari Mustain
Published: October 2022

Oyster mushroom is plant that is quite easy to cultivate because it only requires growing media for oyster mushrooms, oyster mushroom seeds and a humid place for cultivation. Oyster mushroom is a type of plant that is fibrous and contains a lot of water causing the shelf life of oyster mushrooms after harvest is very short. To increase the economic value of oyster mushrooms, it is necessary to process oyster mushrooms into something so that processed oyster mushrooms have a long shelf life, namely by processing oyster mushrooms into chips, but the manufacture of oyster mushroom chips still uses conventional or manual methods so that the quality of the resulting chips is still not good. By using innovative technology through a prototype design tool with the vacuum frying method, it produces chips that are of higher quality than conventional frying methods which are seen from the water content contained in oyster mushroom chips, which is less than 1% with an evaporated water content of 80%. The prototype of this vacuum frying fryer has an overall volume of 260,000 cm3 with an overall length of 100 cm, a width of 40 cm and a height of 65 cm and uses an electric motor of 2461.76 watts or 3.3012 HP
Jornada y tiempo de descanso en la jurisprudencia del TJUE
Authors: Asquerino Lamparero María José
Published: October 2022

El derecho a la limitación de la jornada -y, por consiguiente, el derecho a asegurar unos tiempos mínimos para el descanso- es considerado como un principio social básico. Con base a esa temprana afirmación, el TJUE no ha cesado en dictar asertos que, a la luz de cuestiones judiciales planteadas, tratan de dirimir si las previsiones de los Estados miembros respetan este fundamental derecho del trabajador, siempre desde la óptica de procurar su seguridad y salud. Este objetivo tan primordial provoca la ineludible necesidad de contemplar la normativa que se pone en cuestión sobre el derecho al descanso en términos expansivos y, por esta razón, el TJUE no se aquieta a las designaciones formales que, en su caso, puedan las partes contractuales ofrecer. De esta forma, tal y como se pretende mostrar en estas líneas, se observa cómo el Tribunal de Luxemburgo ante la duda de si un determinado lapso forma o no parte de la jornada, reflexiona para comprobar en qué medida el trabajador queda comprometido con su empresario. Las previsiones contenidas en la Directiva 2003/88/CE arrojan luz también sobre otras cuestiones relevantes y que se relacionan directamente con la jornada del trabajador, dando lugar también a otros interrogantes que, en relación a los descansos y en particular a las vacaciones, el Tribunal también contempla en sus pronunciamientos.
Increasing the Germination Ability of Bidara (Ziziphus nummularia (brum.f.) Wight & Arn) Seeds Through Dormancy Breaking with Chemical Treatment
Authors: Sativa Novriza , Anggraeni Indri , Nafi'ah Hanny Hidayati , Pratama Rama Adi , Nurdiana Dadi
Published: October 2022

The wild jujube plant is a shrub originating from Southeast Asia, which has many benefits, one of which is a traditional medicinal plant. The population of wild jujube plants in Indonesia is still rarely found, even though this plant has many benefits from leaves, roots to stems. With the benefits of wild jujube plants and the community's needs, it is necessary to hold propagation. Jujube plants can massively use seeds but require 2-3 months to sprout in optimum media. This study aimed to determine the effect of dormancy breaking treatment in chemistry on the germination ability of wild jujube seeds. This research has been implemented from July to August 2021 in Pataruman Village Tarogong Kidul-Garut District. This study used a nonfactorial Randomized Block Design method with six treatments and four replications. The first treatment was KNO3 concentration 0.5% (A), KNO3 concentration 1.0% (B), KNO3 concentration 1.5% (C), H2SO4 concentration 25% (D), H2SO4 concentration 50% (E), and H2SO4 concentration 75% (F). The results showed that the H2SO4 treatment with 50% concentration affected parameters normal seedling (%), seeds did not grow (%), growth speed (%), vigour index (%), germinations length (cm), and root length (cm) than KNO3 and another H2SO4 concentration. Consider corrosiveness H2SO4, mask, gloves, and lab coat needed when using it in an outdoor or acid room.
Analysis of Occlusal Force Distributions at the Position of Maximum Intercuspation in Patients with Fixed Restorations
Authors: Halili Rajmonda , Bundevska Jadranka , Bimbashi Venera , Maja Sotir , Dimoski Goce , Alidema Sebahate Hamiti
Published: October 2022

The aim of the study was to determine maximum bite force (MBF) and the percentage of bite force distribution at the position of maximum intercuspation for patients with fixed restorations. Methods and Results: This study enrolled 60 subjects [33(55%) female and 27(45%) male] divided into two groups: The control group (CG) included 30 patients with intact teeth; the experimental group (EG) included 30 patients with fixed restorations. In EG, occlusion was analyzed before and after fixed restoration insertion (FRI). We used the T-Scan III Computerized Occlusal Analysis System 7.0 (Tekscan Inc., South Boston, MA, USA) for analysis. The present study showed a significant difference in MBF between CG and EG before and after FRI (P<0.05). In the present study, there were no statistically significant differences in force distribution in the right and left half of the string between groups (P>0.05). Conclusion: Occlusal analysis with T-Scan III is the only method that enables us to estimate the force differences between the natural teeth and fixed restorations in occlusion.
Enabling Multidisciplinary Collaboration in Rig Acceptance via Digital Rig Acceptance Workflow (DRAW) Solution
Authors: Azman Rashidil Arif , Meor Hashim Meor M Hakeem , Norhashimi Lokman , Norazman Nor Ashraf , Arriffin M Faris , Ghazali Rohaizat
Published: October 2022

With the current rig acceptance workflow practiced by operators globally, the process efficiency gap has been apparent for years. Redundancy, accountability issues and resource wastages can be quite complicated. In a typical workflow, the issues encountered include lack of accountability by inspectors toward item closure, inability to generate snapshots of current status, limited access due to current update via e-mail distribution only, and inefficient process as updates have to be emailed to inspectors. Report formats are not standardized across different disciplines hence the experience is not seamless as there is no one-stop center to view aviation, marine, and HSE inspection items. In fact, some inspection items across disciplines are redundant to each other.

The digitalization of rig acceptance workflow can help to overcome these pain points by having a single platform to allow multidiscipline parties to keep tabs on rig activation status and updates throughout company-wide operations globally during the rig acceptance process. The paper approaches the subject by introducing a much leaner and more seamless method for conducting rig acceptance.

This can be achieved by having a web-based one-stop center for all things related to rig acceptance (i.e., marine, rig, HSE, and aviation). It grants the ability for inspectors and designated personnel (e.g., DSV) to insert comments for each finding as well as the ability for inspectors to assign and edit severity levels (P1/P2/P3) for each finding. The single platform approach allows the possibility to link up the other checklist and findings on the same system and immediately reduce the redundancy of certain items that is similar to other checklists, which can be streamlined online.

Therefore, implementation of this Digital Rig Acceptance Workflow (DRAW) solution can produce a user-friendly online platform to allow inspectors, project teams, management, and rig equipment subject matter experts to access the system anywhere, anytime. DRAW allows status updates (i.e., open/ongoing/close) and clarifications to be communicated via a single platform. It utilizes data input to produce actionable insights (i.e., pie/bar charts, P1/P2/P3 status, etc.) hence generating direct business value via improving process cycle efficiency in a project well life cycle.
Unified Gas Injection and Gas Export Management via Process Automation
Authors: Mohd Sahak Muhammad Zakwan , Myo Thant Maung Maung , Tuan Mat Tengku Amansyah , Castillano Eugene , Bhave Abhijeet
Published: October 2022

For oilfield with high associated gas production or non-associated gas (NAG) wells, gas injection is typically being given as priority, and only the resulting gas flow not taken by injection wells is exported as sales gas. With the unstable price of oil and the shift towards gas as cleaner energy source thus creating higher gas demand, the produced gas maybe prioritized for sales rather than for injection. This paper demonstrates the new approach of managing the gas export and gas injection including the flexibility in prioritizing either utilization options, and managing the impact of changes in injection gas supply accordingly via process analytics and automation. The paper described the concept and key design consideration in integrating the gas injection and gas export process analytics and control in oil and gas fields for improved hydrocarbon recovery application and flexibility of operation modes. It also described step-by-step approach for the technology development and adoption, which is a commendable to be replicated for other production system. Based on a case study, current operation gaps, limitation and opportunity are identified from system review, followed by development of automation strategy, mainly focusing at utilizing the current instrumentations available at the field to manage the gas export and injection accordingly based on desired prioritized mode. With the automation exercise, the operator can now control the system by changing the priority mode and set points at DCS rather than manually adjusting the choke valves opening to regulate the gas injection and gas export flow.
Rigless Plug and Abandonment: A Case Study of Temporary Abandonment Optimization for Slot Re-Entry Preparation in Mahakam Swamp Area
Authors: Pancawisna Gerardus Putra , Khairunnisa Khairunnisa , Suprapto Edy , Hutapea Tioma , Widhiyantoro Anung , Lie Susanto , Sumarhadi Wisnu , Ferdiansyah Mohamad Iqbal , Armain Armain , Andini Amanah Suci , Safitra Adika Fawaz
Published: October 2022

This paper is aimed to present the engineering design and execution of temporary abandonment operation for slot re-entry preparation in Mahakam swamp area. The case study shall cover the design and execution of temporary abandonment campaign in Tambora field of Mahakam swamp area with water depth ranging between three (3) meters to six (6) meters. This rigless operation for slot re-entry and side-track preparation includes permanent plugging, tubing cut, tubing retrieval, casing retrieval, casing scrapper run and cement plug.

The design goes through the engineering calculation of axial load capacity of conductor pipe to support HWU operation, potential barite sagging due to solid content of oil based mud (OBM) in the annulus and the estimated free casing. Moreover, detailed planning is also crucial to improve the optimization with the utilization of wireline on smaller marine vessel such as landing craft tanks (LCT) or self-propelled boat and execute the slickline as well as electricline steps in the temporary abandonment sequence before big marine vessel with HWU comes.

As a result, the campaign managed to prepare four (4) wells in Tambora field of Mahakam swamp area for slot re-entry and sidetrack in seven (7) weeks which included 9-5/8" casing retrieval in one (1) well. The direct cost optimization was up to 75% from the utilization of well intervention units instead of swamp rig in the process. In addition, this operation allowed to troubleshoot and identify possible operational problems including integrity issue prior to the drilling operation such as wellbore clean out, casing free point identification, cement and annulus integrity.

Optimization is mandatory in matured field and drilling operation provides direct impact to the optimization. In addition, operation in swamp area is uniquely novel where it provides different kind of challenges in terms of engineering and operation particularly in rigless operation.
Application of High-Definition Reservoir Scale Mapping-While-Drilling with Comprehensive Formation Evaluation in the Challenging Low Resistivity Contrast Environment
Authors: Wahid Ali Nurul Athirah , Alang Khairul Anuar , Wang Haifeng , Goh Jin Wang Arthur , Chuah Mei Mei Stefanie , Sapian Nik Fazril Ain , Bt M Zaid Siti Nurfarhana , Rafiuddin Nur Liyana , AL Naupa Nagarajan , A Aziz Khairul Ikram
Published: October 2022

The horizontal wells within the context of this case study are located offshore Malaysia, where the reservoirs vary in grain size and quality. The infill wells include 3 oil producer wells targeting S reservoir and 1 horizontal sidetrack well targeting R1-R3 subunit reservoirs. The horizontal wells’ objective is to optimize minimum lateral length of 1,000-2,000ft MD at 1/3 vertical standoff from GOC within the target oil column. Based on recent data from offset wells, the fluid contacts (GOC and OWC) remained uncertain, hence well placement within the target oil column becomes the main challenge. The wells are expected to have low resistivity contrast between oil and water composition. In this kind of reservoir environment, the standard reservoir mapping tool may not be sufficient for differentiating reservoir fluid properties of oil and water bearing formation.

For such challenging condition, an integrated real-time well placement technology, high tier triple-combo logs, Neutron Near- Far count and Formation Sigma measurements were deployed to fully achieve drilling objectives. 3 horizontal wells with 1 horizontal sidetrack well were successfully executed within the target zone, achieving objectives beyond expectation. A new generation of LWD tool including high-definition reservoir mapping-while-drilling technology with advanced inversion was deployed to fulfill geosteering requirements. The workflow presented in this project is a synergized scope of multi-domain, from both drilling and subsurface.

This case study demonstrated the value of high-definition reservoir scale mapping technology. It provides an innovative and deterministic method to identify low resistivity low contrast boundaries of oil from transitional water zone which was difficult to be achieved by conventional reservoir mapping tool. At the landing section, the high-definition tool helped to reveal clearly OWC below the tool with greater confidence compared to the standard tool. The information from the high-definition tool, paired with the fluid identification offered from Neutron-Density and Neutron Near- Far count together were essential for an accurate landing. The usage of reservoir scale mapping technology in the horizontal section revealed the tilted OWC and reservoir structure at the same time, which allowed the team to achieve the required minimum production length while maintaining required standoff from the OWC. All wells were geosteered successfully with the accomplishment of placing the trajectories in optimum positions despite having a tight TVD window.
An EO based Parameter Independent Fuzzy kNN Classifier for Classification of Medical datasets
Authors: Vommi Amukta Malyada , Battula Tirumala Krishna
Published: October 2022

The kNN classifier is the most popular, supervised machine-learning technique but the main disadvantage of this algorithm is that it has very restricted access to the class distributions in a training point set and treats all the instances equally. In kNN classification, fuzzy sets are used to obtain the membership degrees of each point to the classes known as fuzzy kNN (FkNN) classification. Although FkNN classifier enhances the performance of the kNN, it doesnot consider the effect of noisy and redundant instances which makes it ineffective. Moreover, the performance of kNN is dependent on the value of k (number of nearest neighbours) .Considering these issues, we present a novel algorithm which simultaneously tunes the class dependent feature weights along-with k value using an effective meta-heuristic algorithm, Enhanced Equilibrium Optimization technique. A number of experiments have been conducted on different biomedical datasets and the proposed approach has outperformed the other standard classifiers in terms of accuracy.
Efficacy of bladder training in the overactive bladder symptoms improvement: systematic review protocol
Authors: Rocha Anna Karoline Lopes , Monteiro Silvia Elizate , Volpato Maria Palharini , Verleun Dinah , Valim Lilian , Riccetto Cassio , Botelho Simone
Published: October 2022

Background
The International Continence Society recommends that first-line treatment of overactive bladder syndrome symptoms and urgency urinary incontinence is performed by conservative interventions. Bladder training is considered one of the types of behavioral intervention, which is characterized by health education associated with scheduled voiding regimen with gradually adjusted voiding intervals. The aim of this study will be to investigate and update whether bladder training can promote improvement of symptoms of individuals with overactive bladder with or without urgency urinary incontinence.
Methods
A bibliographic search will be conducted in eight databases, no data or language restrictions: PubMed, PEDro, SciELO, LILACS, Cochrane Library, Web of Science, EMBASE, CINAHL, by handing searching. A combination of search terms including ‘bladder training’, 'overactive bladder', ‘urinary incontinence’ and 'urinary urgency incontinence' with common Boolean operators will be used. Specific search terms will be combined with either MeSH and search descriptors terms and appropriate permutations for each database. Search findings will be imported into the Reference Management Software (Mendeley 2.67.0) then uploaded where two reviewers will screen the titles, abstracts and retrieved full text. In case of conflicts and moderate consensus discussions, a third reviewer will be available. The Mixed Methods Appraisal Tool (MMAT) will be used to appraise the quality of mixed studies (quantitative and qualitative) by limiting them to criteria. The primary outcome will be the improvement of OAB symptoms and the secondary outcomes will be the quality of life, functional assessment and adverse events, which can be assessed by questionnaires and measurement instruments. Meta-analysis, if plausible, will be performed by the software Review Manager 5.4. Cochrane RoB 2 assesses the risk of bias for randomized trials and quality of evidence will be assessed by GRADE.
Discussion
This study is a review of randomized controlled studies to analyze the efficacy of bladder training improving overactive bladder syndrome symptoms. The study design of randomized controlled trials for a higher level of scientific evidence was chosen. The aim is to obtain results that allow further studies and evidence that this intervention generates beneficial effects in the sample studied.
Systematic review registration: PROSPERO CRD42022301522.
Light-driven C-H bond activation mediated by 2D transition metal dichalcogenides
Authors: Li Jingang , Li Hao , Zhu Haoyue , Zhang Tianyi , Gu Yuqian , Wu Zilong , Huang Suichu , Akinwande Deji , Terrones Mauricio , Redwing Joan , Zheng Yuebing
Published: October 2022

C-H bond activation enables the facile synthesis of new chemicals. While C-H activation in short-chain alkanes has been widely investigated, it remains largely unexplored for long-chain organic molecules. Here, we report light-driven C-H activation in complex organic materials mediated by 2D transition metal dichalcogenides (TMDCs) and the resultant solid-state synthesis of luminescent carbon dots in a spatially resolved fashion. Through the first-principle calculations, we unravel that the defects and oxidized states in 2D TMDCs lead to efficient C-H activation and chemical reaction. Furthermore, we exploit the light-controlled “point-and-shoot” chemical reaction for versatile carbon dot patterning and optical encoding of encrypted information. Our results will shed light on 2D materials for C-H activation in a variety of organic compounds for applications in organic chemistry, photonic materials, and environmental remediation.
The prevalence of contraceptive use among postpartum women during the early phase of COVID-19 outbreak: A cross sectional study
Authors: Sathitloetsakun Sarochinee , Puangsricharoen Pimpitcha , Phutrakool Phanupong , Maitreechit Duangporn , Santibenchakul Somsook , Jaisamrarn Unnop
Published: October 2022

We investigated the prevalence of postpartum contraceptives during the COVID-19 outbreak and identify factors associated with contraceptive initiation. We reviewed the electronic medical records of 4506 postpartum women who delivered at King Chulalongkorn Memorial Hospital (KCMH) during the early phase of COVID-19 in Thailand and the historical cohort period. A total of 3765 women (83.6%), of which 1821 delivered during the pandemic and 1944 during the historical cohort period, were included in this study. The proportion of women who initiated modern contraceptives at six-week postpartum was comparable between the COVID-19 (73.4%) and historical cohort (75.3%) (p = 0.27) periods. The proportion of women who initiated highly effective contraception tended to be higher during the historical cohort period (22.5%) than during the COVID-19 period (19.7%) (p = 0.05). Accessing a six-week postpartum check-up was independently associated with highly effective contraceptive initiation, of which the adjusted odds ratio (OR) (95% confidence interval) was 3.01 (2.26 to 4.02). The findings highlight that the pandemic worsened the healthcare system by limiting access to postpartum check-ups, which contributed to fewer opportunities to initiate highly effective contraception.
Age has a U-shaped Relationship with Breast Cancer Outcomes in Women
Authors: Xie Yujie , Wei Suosu , Huang Zhen , Huang Kai , Wei Chunyu , Xu Jinan , Dong Lingguang , Zou Quanqing , Yang Jianrong
Published: October 2022

Background and Objectives
There is insufficient information available on how breast cancer prognosis is affected by age at diagnosis. Our study aimed to examine the association between age at diagnosis and overall survival (OS), breast cancer-specific survival (BCSS) and disease-free survival (DFS) rates.
Methods
1054 breast cancer patients were obtained in our retrospective cohort study from March 7, 2013 to December 31, 2019. Patients were dividedinto four groups based on their age. Different age groups were described using the Kaplan-Meier method for OS, BCSS and DFS survival rates. A model of Cox proportional hazards ratio (HR) with restricted cubic splines (RCS) and smooth curve fitting were usedto estimate 95% confidence interval (CI) and hazard ratios (HRs) of OS, BCSS and DFS rates.
Results
71 patients (6.74%) died and 144 patients (13.66%) recurred during a median follow-up of 4.86 years. Quarter 2 showed the best OS, BCSS, and DFS rates in the Kaplan-Meier survival analysis. The outcomes of RCS analysis indicated that there was a U-shaped relationship between the age and OS, BCSS and DFS rates despite after adjustment for other confounding factors, the inflection points of OS, BCSS and DFS rates were 44years, 37years and 41years.
Conclusions
In Asian women, there is a U-shaped association between age at diagnosis and breast cancer outcomes.
Prediction of non union in diaphysis of long bones in adults
Authors: Gupta Anupam
Published: October 2022

Purpose
The study was conducted to analyze the feasibility of Rust and Modified Rust score to predict non union in adult long bones.
Methods
Literature was searched using Pubmed and articles pertaining to prediction of long bones studied. In this study randomized patients were prospectively analyzed and selected for radiographic RUST and Modified Rust scores, after internal fixation of fractures of tibia, humerus and femur.
Results
64 patients were analyzed out of which 16 cases were lost in follow up. Out of 48 patients,we predicted 6 non union cases out of which 2 patients underwent dynamization and 1 pat injPRP. The remaining 3 developed non union. Rust score and Modified Rust scores are good tools for prediction on nonunion in adult long bones.
Conclusion
Our rate of non union was 6.25% which is within the nonunion rate published in the literature.
Flavonoid compound from Agrimonia Pilosa Ledeb improves adipose insulin resistance by alleviating oxidative stress and inflammation
Authors: Guo Tingwang , Pan Yun , Yang Lin , Chen Gang , Deng Jia , Zhu Liancai
Published: October 2022

Background
Researches and practice of Chinese medicine indicated that Agrimonia Pilosa Ledeb could improve insulin resistance (IR) and treat type 2 diabetes (T2DM). Flavonoid component (FC) was collected from Agrimonia Pilosa Ledeb. The aim of this study was to elucidate the effects of FC on glucose metabolism to improve IR by suppressing oxidative stress and inflammation.
Methods
By overdosed glucose and insulin or high-fat diet to establish adipocytes or mice IR model. The uptake of 2-NBDG and glucose consumption were measured to verify insulin sensitivity in vitro and vivo. Reactive oxidative species (ROS) were detected by flow cytometry, activity of superoxide dismutase (SOD) and content of malondialdehyde (MDA) were also measured. Meanwhile, factors related to insulin signal pathway such as PPARγ, insulin receptor substrate-1 (IRS-1) and GLUT4, factors related to oxidative stress such as NF-E2-related factor 2 (Nrf2), and expression and secretion of inflammatory cytokines such as NF-κB, IL-1β, IL-6 and TNF-α were tested. Furthermore, the JNK/PI3K/Akt signal pathway were also explored.
Results
FC ameliorated the impaired glucose metabolism significantly. Further study indicated that FC could promote the expression related to insulin signal pathway to improve insulin resistance. What’s more, it could not only upregulated PPARγ with the similar efficacy as pioglitazone (Piog) straightway. But FC also decreased the endogenous ROS, lowered the content of MDA, increased the activity of SOD and expression of Nrf2 to facilitate oxidative homeostasis. It also attenuated expression and secretion of inflammatory cytokines obviously. At last, the underling mechanism JNK/PI3K/Akt pathway was improved in adipocytes and adipose tissue.
Conclusion
FC could ameliorate glucose metabolism and improve IR. It exerted these effects by suppressing oxidative stress and inflammation. FC from Agrimonia Pilosa Ledeb has a good prospect to be drugs or functional foods for IR and T2DM.
Synthesis, Antimicrobial Evaluation, and Docking Studies of Substituted New Chromone linked 1,2,3-Triazoles
Authors: Nipate Amol S. , Jadhav Chetan K. , Chate Asha V. , Dofe Vidya S. , Dixit Prashant P. , Sharma Prachi , Gill Charansingh. H.
Published: October 2022

In Search of new antibacterial, antifungal agents with improved potency, herein we report the synthesis of a series of new substituted 2-(4-fluorophenyl)-3-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)-4H-chromen-4-one derivatives (6a‐q), starting from acetophenone. All the Synthesized compounds have been screened for in vitro antibacterial and antifungal activity by using the agar well diffusion method. Among fifteen synthesized compounds, four chromone derivatives i. e. (6a-b), (6h), and (6i) have shown proficient antimicrobial activities. Compound (6a) showed powerful inhibitory activity against all bacterial pathogens but it was not that effective against fungal pathogens on the other hand compound (6b) showed satisfactory activity against fungal pathogens as well. The activity of compounds (6h) and (6i) against S. aureus was remarkable. Other compounds were found active against a few pathogens but activity was good. The compound (6b) was found very effective in inhibiting the growth of S. aureus ATCC 6538 at a low concentration with MIC 190 µg/ml.
Association between nociplastic pain and premature endocrine therapy discontinuation in breast cancer patients
Authors: Joyce Elizabeth , Carr Grant , Wang Sidi , Brummett Chad M. , Kidwell Kelley M. , Henry N. Lynn
Published: October 2022

Purpose
At least five years of adjuvant endocrine therapy (ET) is recommended for patients with hormone receptor-positive invasive breast cancer to reduce cancer recurrence risk. Up to half of patients prematurely discontinue ET, often due to musculoskeletal pain. Nociplastic pain is abnormal central nervous system pain processing without evidence of tissue or neuronal damage. This study aimed to evaluate the relationship between baseline nociplastic pain and ET discontinuation.
Methods
This was a retrospective, single center, cohort study. Included patients were female, had stage 0-III invasive breast cancer, did not receive neoadjuvant therapy, and completed quality of life questionnaires prior to breast surgery, including Fibromyalgia Survey for nociplastic pain. Clinical data including duration of ET were abstracted from the medical record. Patient characteristics were analyzed with t-tests and chi-squared tests, as appropriate. Univariate and multivariable regressions were performed with Cox proportional hazard models.
Results
681 patients diagnosed between 2012–2019 met inclusion criteria; 480 initiated ET and were included in the analysis. Of these 480 patients, 203 (42.3%) prematurely discontinued initial ET therapy. On univariate analysis, tamoxifen use (hazard ratio [HR] 0.70, p = 0.021) and premenopausal status (HR 0.73, p = 0.04) were inversely associated with ET discontinuation, while Fibromyalgia Score was positively associated (HR 1.04, p = 0.043). On multivariable analysis, baseline Fibromyalgia Score remained associated with ET discontinuation.
Conclusion
Nociplastic pain present prior to surgery was associated with premature ET discontinuation. Fibromyalgia Score screening may be useful for evaluating ET discontinuation risk. Treatments targeting nociplastic pain may be more effective for treating ET-emergent pain.
Safety and Feasibility of Anti-CD19 CAR T Cells Expressing Inducible IL-7 and CCL19 in Patients with Relapsed or Refractory Large B-cell Lymphoma
Authors: Qian Wenbin , Gao Jimin , Zhang Jinyi , Lei Wen , Zhao Ai , Liu Hui , Yang Chunmei , Wei Cheng , Guo Shanshan , Chen Zhilu , Guo Qunyi , Li Linjie , Zhao Mingzhe , Wu Gongqiang
Published: October 2022

Chimeric antigen receptor (CAR) T cell therapy provides a potentially curative option for patients with relapsed or refractory large B-cell lymphoma (R/R LBCL). However, there are major limitations of this therapy which result in treatment resistance in B-cell malignancies, including the inadequate CAR T cell trafficking and tumor infiltration, frequent tumor antigen escape and poor CAR T cell persistence. Here we report the development of the CD19-specific CAR T cells capable of expressing interleukin (IL)-7 and chemokine (C-C motif) ligand (CCL)-19 upon CD19 engagement (referred to as 7 × 19 CAR T cells), the preclinical study and multicenter phase 1b clinical trial of 7 × 19 CAR T cell therapy in patients with R/R LBCL (NCT03258047). The clinical trial of 7 × 19 CAR T cells showed a favorable safety profile in a cohort of R/R LBCL patients (n = 39), with grade 3 cytokine release syndrome occurred in 5 (12.8%) patients and grade 3 or higher neurotoxicity in 4 (10.3%) patients. The overall response rate at 3 months post-single infusion was 79.5% (complete remission, 56.4%; partial response, 23.1%). With a median follow-up of 32 months, the median progression-free survival was 13 months, and the median overall survival was not reached, with an estimated rate of 53.8% (95% CI, 40.3–72.0%) at two years. Together, these long-term follow-up data from the multicenter clinical study suggest that 7 × 19 CAR T cells can induce durable responses with a median overall survival of greater than 2 years, and have a manageable safety profile in patients with R/R LBCL.
SSELM-neg: Spherical search-based extreme learning machine for drug-target interaction prediction
Authors: Hu Lingzhi , Fu Chengzhou , Ren Zhonglu , Cai Yongming , Yang Jin , Xu Siwen , Xu Wenhua , Tang Deyu
Published: October 2022

Background: Experimental verification of a drug discovery process is expensive and time-consuming. Therefore, efficiently and effectively identify drug–target interactions (DTIs) has been research focus. In present, many machine learning algorithms are used for predicting drug-target interactions. The key idea is to train the classifier using existing DTI so as to predict new or unknown DTI. However, there are various challenges such as class imbalance and parameter optimization of many classifiers that need to be solved before developing an optimal drug-target interaction model.
Methods: In this paper, we propose a framework named SSELM-neg for drug-target interaction prediction, in which a screening approach was used to choose high quality negative samples and a spherical search approach is used to optimize the parameters of the extreme learning machine.
Results: Results show that the performance of the proposed technique outperforms the other state-of-the-art methods in 10-fold cross-validation experiments in terms of AUC(0.986, 0.993, 0.988, 0.969 ) and AUPR(0.982, 0.991, 0.982, 0.946) for E dataset, GPCR dataset, IC dataset and NR dataset.
Conclusion: Screening approach produce the high quality negative samples with the same numbers of the positive samples, which solve the class imbalance problem. Extreme learning machine was optimized by a spherical search approach in identifying DTIs. Therefore, our models achieve better performance than other state-of-the-art methods.
Propolis protects the lungs from radiation-induced systemic oxidative damage
Authors: TAYLAN Mahsuk , DOGRU Sibel , TAYSI Seyithan
Published: October 2022

Background: Propolis is well known as an antioxidant natural product. This study aimed to detect the radioprotective effect of propolis against oxidative lung injury caused by cranial irradiation.
Methods: Thirty-two rats were randomly divided into four equal groups. Group A, sham control group (n = 8); group B,propolis control group (n = 8);group C,irradiation alone group (n = 8);and group D,irradiation plus propolis group (n = 8). The latter two groups were exposed to a single dose (5 Gy) of cranial irradiation. The saline dosage was 1 mL/kg/day, and the propolis dosage was 80 mg/kg/day. The total oxidant status(TOS), total antioxidant status (TAS), oxidative stress index (OSI), arylesterase, lipid hydroperoxide (LOOH), ceruloplasmin, total thiol (SH), and paraoxonase (PON) levels of lung tissues were measured.
Result: TOS, OSI, and lipid hydroperoxide levels were significantly higher in group C than in all other groups. TOS, OSI, and lipid hydroperoxide were significantly lower, and TAS and total thiol levels were higher in group D than in group C.
Conclusion: The use of propolis has a significant protective effect against the adverse effects of oxidative stress-related lung injury caused by ionizing radiation.
Cross-linguistic Authorship Attribution and Author Profiling. Is Machine Translation the Solution?
Authors: Mikros George , Boumparis Dimitris
Published: October 2022

This paper aims to explore whether cross-linguistic authorship attribution and author's gender identification are feasible using Machine Translation (MT) as a method to bridge the language gap. We designed a series of computational stylistics experiments to explore whether the stylometric signal survives through the MT process. We compiled an extensive blog corpus in Greek containing 100 authors, balanced in gender with 50 texts from each author. Then, we used Google's Neural Machine Translation to automatically translate each text into English. We ran several classification experiments using the Random Forest algorithm in authorship attribution and gender profiling tasks employing different feature groups in both the source language (Greek) and the machine-translated (English) corpora. Moreover, we trained models in the source language and used the texts in the target language as the unseen test set, to simulate a cross-linguistic prediction. The results showed that cross-linguistic gender identification could be achieved reliably using n-gram features. Authorship attribution, however, was not feasible in our cross-linguistic experimental setting, although features of lexical diversity exhibited promising results. Finally, when performed using training and testing set from the same language, both authorship attribution and gender identification exhibit similar accuracy across the full range of the feature groups used.
Effect of Influencing Parameters on Developing Aluminium Metal Foam by using Powder metallurgy technique with foaming agent as a Wax Powder
Authors: Madgule Mahadev , G Sreenivasa C , Borgaonkar Avinash V.
Published: October 2022

Aluminum metal foam has become an advanced popular material because it has excellent mechanical and electrical properties and is lightweight. The present work developed the Aluminium metal foam specimen using wax powder as a blowing agent through the powder metallurgy method. The effect of process parameters such as powder size, stirring speed, sintering temperature, and foaming agent content on the mechanical behavior of the developed specimens has been studied experimentally. In the design of experiments, the Taguchi orthogonal L9 array has been implemented. The percentage of Porosity was estimated using the Archimedes principle, and mechanical behaviors such as flexural, tensile, and compressive strength were determined. The ANOVA analysis of variance it's been carried out to check the significant parameters affecting the mechanical behavior of developed specimens. It was observed that the powder size is the highly significant parameter, followed by stirring speed, the content of the foaming agent, and sintering temperature. The Maximum Porosity 71.30%, Compresssion strength 12.01MPa, Tensile strength 6.16 MPa, Flexural strength 5.18 MPa. The microstructure study reveals that there is no any adequet compostion in the specimen. The novelty in this research work is using a novel foaming agent as a Wax powder to develop aluminium metal foam and attained good properties.