bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Novel Pharmacists’ Risk in Pharmacotherapy (PHARIPH) Scale for Identification of Factors Affecting the Safety of Hospital Pharmacotherapy—An Observational Pilot Study
Authors: Fedorowicz Olga , Rypicz Łukasz , Wiela-Hojeńska Anna , Jaźwińska-Tarnawska Ewa , Witczak Izabela
Published: January 2022

Background: The widespread occurrence of medication errors (MEs) has become a global problem because it poses a serious threat to the health and lives of patients, can prevent the achievement of treatment goals, undermines patient trust in the health care system, and increases treatment costs. The purpose of this study was to develop an appropriate tool to identify key risk factors that hospital pharmacists believe threaten pharmacotherapy safety in the hospital. Methods: A diagnostic survey method using the authors’ PHARIPH (Pharmacists’ Risk in Pharmacotherapy) scale and authorial questions was used to identify risks that may result in patient pharmacotherapy errors at the hospital pharmacist level. A total of 125 Polish hospital pharmacists participated in the study. Results: The original authors’ created PHARIPH scale was characterized by a Cronbach’s alpha coefficient of 0.958. According to the surveyed pharmacists, the greatest threat to pharmacotherapy safety was misreading of a doctor’s order (similar drug nomenclature) and preparing a wrong drug (similar drug packaging, similar drug nomenclature). Female pharmacists compared to male pharmacists attributed significantly higher importance to such risk factors such as pharmacist’s ignorance of a list of drug substitutes (p = 0.047, risk 8), preparation from an expired/withdrawn drug (p = 0.002, risk 14), preparation from a drug stored in inappropriate conditions (p = 0.05, risk 15), preparation of drugs ordered in hospital and PODs (patients’ own drugs) without checking for possible drug duplication (p = 0.011, risk 17) and their potential effect on patient safety. Conclusions: The PHARIPH scale could be applied as a novel tool for identification of pharmacotherapy risks.
Effect of Knee Orthosis Pressure Variation on Muscle Activities during Sit-to-Stand Motion in Patients with Knee Osteoarthritis
Authors: Yamamoto Hiroaki , Okamatsu Shogo , Kitagawa Kodai , Wada Chikamune
Published: January 2022

It is yet not known whether the variation in knee orthotics pressure would lead to changes in muscle activity during-sit-to-stand postural transition in patients with knee osteoarthritis (OA). Participants in this analytical study were patients with knee OA. The research design was a cross-sectional study. They were enrolled in the study through a sample of convenience method. The primary outcome measure was surface electromyography for measuring muscle activity while changing knee orthotics pressure during sit-to-stand motion. Data were summarized with mean and standard deviation while Friedman’s test was performed for multiple comparison of variables, at a significance level of p = 0.05. Seven elderly patients with knee osteoarthritis (mean age 71.4 ± 11.8 years) participated in the study. Moderate orthotics (7.3 mmHg) led to a significant increase in the percentage maximum voluntary contraction (MVC) of tibialis anterior compared to that obtained without orthotics. Rectus femoris, vastus medialis, vastus lateralis, and biceps femoris tended to increase the % MVC with an increase in wearing pressure. It was therefore concluded that the muscle activity during sit-to-stand motion could be increased in patients with knee osteoarthritis by wearing flexible orthotics with varying pressure.
Burnout Assessment Tool (BAT): Validity Evidence from Brazil and Portugal
Authors: Sinval Jorge , Vazquez Ana Claudia S. , Hutz Claudio Simon , Schaufeli Wilmar B. , Silva Sílvia
Published: January 2022

The Burnout Assessment Tool (BAT) has been gaining increased attention as a sound and innovative instrument in its conceptualization of burnout. BAT has been adapted for several countries, revealing promising validity evidence. This paper aims to present the psychometric properties of the Brazilian and Portuguese versions of the BAT in both the 23-item and 12-item versions. BAT’s validity evidence based on the internal structure (dimensionality, reliability, and measurement invariance) and validity evidence based on the relations to other variables are the focus of research. A cross-sectional study was conducted with two non-probabilistic convenience samples from two countries (N = 3103) one from Brazil (nBrazil = 2217) and one from Portugal (nPortugal = 886). BAT’s original structure was confirmed, and it achieved measurement invariance across countries. Using both classic test theory and item response theory as frameworks, the BAT presented good validity evidence based on the internal structure. Furthermore, the BAT showed good convergent evidence (i.e., work engagement, co-worker support, role clarity, work overload, and negative change). In conclusion, the psychometric properties of the BAT make this freely available instrument a promising way to measure and compare burnout levels of Portuguese and Brazilian workers.
Assessing the Visualization-Based Decision Support System for Environmental Impact Assessments
Authors: Lee Seo-young , Shin Sanghee , Kim Hakjoon , Kim Min-Kyung , Yoon So-Yeon , Lee Sangdon
Published: January 2022

Even though environmental impact assessments (EIAs) have been an important tool for environmental decision-making, most EIAs are published as a mix of text and tabular data that is not easily accessible to or understandable for the public. In this paper, we present a decision support system (DSS) that supports the decision-making of stakeholders in the EIA stage. The system was designed to improve the public’s understanding of stakeholders before and after a construction project by providing visualization of key environmental elements. We recruited 107 participants to test the usability of the system and examined the impacts of individual differences between the participants on their perceptions of the system, including their environmental expertise and computer self-efficacy. The results showed that the proposed system had high usability, especially for users with high computational efficacy and environment expertise. The system could thus help to improve the communication between the public and experts during public hearings and enhance the environmental literacy of the public.
Single Nucleotide Polymorphism of TWIST2 May Be a Modifier for the Association between High-Density Lipoprotein Cholesterol and Blood Lead (Pb) Level
Authors: Yang Chen-Cheng , Dai Chia-Yen , Luo Kuei-Hau , Lee Kuo-Wei , Wu Cheng-Hang , Hung Chih-Hsing , Chuang Hung-Yi , Kuo Chao-Hung
Published: January 2022

The association between lead (Pb) exposure and lower high-density lipoprotein cholesterol (HDL-C) was reported; however, the mechanism was unclear. Our purpose was to investigate the association of Pb, lipid profile, and to study the associated SNPs using a genome-wide association study (GWAS). A total of 511 participants were recruited to check blood Pb levels, lipid profile, and genotypes with Taiwan Biobank version 2.0 (TWB2). Our main result shows that HDL-C was significantly negatively associated with blood Pb levels, adjusted for gender, body mass index (BMI), and potential confounders. In addition, via the TWB2 GWAS, only two SNPs were found, including rs150813626 (single-nucleotide variation in the TWIST2 gene on chromosome 2), and rs1983079 (unclear SNP on chromosome 3). Compared to the rs150813626 GG carriers, the AA and AG carriers were significantly and negatively associated with HDL-C. We analyzed the interaction of rs150813626 SNP and blood Pb, and the HDL-C was consistently and negatively associated with blood Pb, male, BMI, and the rs150813626 AA and AG carriers. Moreover, the rs150813626 AA and blood Pb interaction was significantly and positively associated with HDL-C. In conclusion, the SNPs rs150813626 and rs1983079 were significantly associated with HDL-C in Pb-exposed workers. Furthermore, the interaction of rs150813626 AA and blood Pb had a positive influence on HDL-C. TWIST may inhibit osteoblast maturation, which might relate to bone Pb deposition and calcium metabolism. The mechanism needs more investigation in the future.
Changes in the Retail Food Environment in Mexican Cities and Their Association with Blood Pressure Outcomes
Authors: Armendariz Marina , Pérez-Ferrer Carolina , Basto-Abreu Ana , Lovasi Gina S. , Bilal Usama , Barrientos-Gutiérrez Tonatiuh
Published: January 2022

Shifting food environments in Latin America have potentially contributed to an increase in the consumption of ultra-processed foods and sugar-sweetened beverages, along with decreases in healthy foods, such as fruits and vegetables. Yet, little is known about the impact that such changes in the food environment have on blood pressure in low- and middle-income countries, including Mexico. We utilized individual-level systolic and diastolic blood pressure (SBP and DBP) measures from the 2016 Mexican Health and Nutrition Survey (ENSANUT, n = 2798 adults). Using an inventory of food stores based on the economic census for 2010 and 2016, we calculated the change in the density of fruit and vegetable stores, convenience stores, and supermarkets. Multilevel regression was used to estimate the association between the 2010–2016 food environment neighborhood-level changes with individual-level blood pressure measured in 2016. Declines in neighborhood-level density of fruit and vegetable stores were associated with higher individual SBP (2.67 mmHg, 95% CI: 0.1, 5.2) in unadjusted models, and marginally associated after controlling for individual-level and area-level covariates. Increases in the density of supermarkets were associated with higher blood pressure outcomes among adults with undiagnosed hypertension. Structural interventions targeting the retail food environment could potentially contribute to better nutrition-related health outcomes in Latin American cities.
Physical Therapists and Physical Therapist Assistants’ Knowledge and Use of the STEADI for Falls Risk Screening of Older Adults in Physical Therapy Practice in the United States
Authors: Vincenzo Jennifer L. , Schrodt Lori A. , Hergott Colleen , Perera Subashan , Tripken Jennifer , Shubert Tiffany E. , Brach Jennifer S.
Published: January 2022

Fall-risk screening and prevention is within the scope of physical-therapy practice. Prior research indicates United States-based physical therapists (PTs) and physical-therapist assistants (PTAs) use the Centers for Disease Control and Prevention’s STEADI (Stopping Elderly Accidents, Deaths, and Injuries) toolkit for community-based fall-risk screenings of older adults. However, clinically based fall-risk screenings and knowledge and use of the STEADI by PTs and PTAs is unknown. We conducted a cross-sectional survey distributed to a convenience sample of PTs and PTAs in the United States through email blasts and social media. PTs and PTAs (N = 425) who responded to the survey and worked in clinical settings with older adults were included. Eighty-nine percent of respondents reported conducting clinical fall-risk screening. Approximately 51% were ‘familiar’ to ‘very familiar’ with the STEADI, and 21.7% of the overall sample were not familiar at all. Only 26.1% utilize the STEADI for clinical fall-risk screening. Of the respondents who were ‘very familiar’ with the STEADI (n = 132, 31.1%), 84.1% (n = 111) reported using the STEADI in clinical practice. Seventy-six percent of respondents who use the STEADI implemented it by choice even though the majority (52.1%, n = 63) did not have it embedded in their documentation/workflow. Some PTs/PTAs can and do manage falls using the STEADI, but there is a gap in knowledge and use of the STEADI for falls management among PTs and PTAs in the United States. Further research is needed to identify the tools PTs use for multifactorial-fall screening and management and the impact of PTs’ use of the STEADI on patient outcomes.
Building Resilient Cities: Climate Change and Health Interlinkages in the Planning of Public Spaces
Authors: Orsetti Eleonora , Tollin Nicola , Lehmann Martin , Valderrama Vanessa Agudelo , Morató Jordi
Published: January 2022

Greenhouse gases emissions resulting from the combustion of fossil fuels are worsening air quality and affecting the climate system. While climate change impacts on meteorological variables affects air quality by altering the concentration and distribution of pollutants, air pollution significantly influences the climate, leading to negative impacts on human health. Due to the combination of high temperatures, air pollution, and high population density, cities are particularly vulnerable to climate change impacts. The planning and design of public spaces aimed at climate change mitigation and adaptation can result in multiple co-benefits for human health, while reducing social inequalities. To address the major research gaps in the communication between health and planning experts, and the lack of capacity among public sectors and policy makers, it is necessary to promote capacity building and knowledge sharing between the planning and health sectors. The purpose of this article is to develop preliminary recommendations for a process that allows a comprehensive assessment of the interlinkages between climate and health, social, environmental, and economic vulnerabilities, and the quality of the urban spaces, to support local governments, policymakers, and education institutions in making informed decisions for public spaces. The methods applied were a literature review and interviews with experts.
What One Gets Is Not Always What One Wants—Young Adults’ Perception of Sexuality Education in Poland
Authors: Izdebski Zbigniew , Dec-Pietrowska Joanna , Kozakiewicz Alicja , Mazur Joanna
Published: January 2022

There is a discrepancy between the educational needs and the opportunities to obtain reliable knowledge about sexuality in adolescence. This study aimed to assess the conjunctive influence of family and school in shaping this knowledge. Methods: Data were collected retrospectively within a cross-sectional survey conducted in Poland in 2017 (18–26 yrs; N = 595). The respondents’ experiences in terms of the presence and quality of sexuality education (SE) at school and in conversations with parents about related issues were considered. Results: Of all the respondents, 31.1% had no sexuality education classes in school or rated them as useless, 41.5% never discussed sexuality-related topics with parents and both were true for 17.6%. Puberty and contraception were most frequently discussed with parents, while sexual pleasure and masturbation were discussed least frequently. The diversity of topics taken up with parents and the possibility of discussions with mothers turned out to be the most important factors for shaping adolescents’ knowledge. A relationship with the quality of sexuality education at school was additionally revealed for girls, while a relationship with talking to fathers was revealed for boys. Conclusions: Schools and families should work together to strengthen proper sexual development by meeting adolescents’ needs in the field of their knowledge on human sexuality.
Influence of Freeze-Dried Diet on Oral Hygiene Indicators in Strict Isolation Condition of an Analog Space Mission
Authors: Gronwald Barbara Janina , Kijak Karina , Jezierska Karolina , Gronwald Helena Anna , Kosko Kamil , Matuszczak Mikołaj , Bielawska-Victorini Hanna Barbara , Podraza Wojciech , Orzechowski Leszek , Lietz-Kijak Danuta
Published: January 2022

Analog space missions were created to study the human factor in extraordinary conditions that would occur in future space habitats. Isolation has been shown to cause stress and disrupt individuals’ daily routine, which can also affect their oral hygiene and lead to an increased risk of dental caries and gingivitis. The astronauts’ specific freeze-dried diet is associated with “lazy” chewing, potential dehydration and vitamin A deficiency, which may adversely affect their saliva. The aim of this study is to investigate the influence of the freeze-dried diet on selected oral hygiene indicators in analog astronauts (AA) enduring strict isolation conditions during six consecutive analog space missions at the LunAres Research Station. During the experiment the oral hygiene and gingival inflammation status measurements were conducted on the group of AAs at the beginning and at the end of each mission. Measurements included four oral hygiene indicators: API, sOHI, PI by Silness and Loe and GBI by Ainamo and Bay. Each AA’s individual scores were noted and analyzed. Statistically significant reduction in the amount of plaque and intensity of gingival bleeding was observed over the course of the study, which could indicate positive results of applied oral hygiene procedures despite unfavorable dietary and stressful isolation conditions.
Understanding Agri-Food Traceability System User Intention in Respond to COVID-19 Pandemic: The Comparisons of Three Models
Authors: Tseng Yafen , Lee Beyfen , Chen Chingi , He Wang
Published: January 2022

Scientists believed the outbreak of COVID-19 could be linked to the consumption of wild animals, so food safety and hygiene have become the top concerns of the public. An agri-food traceability system becomes very important in this context because it can help the government to trace back the entire production and delivery process in case of food safety concerns. The traceability system is a complicated digitalized system because it integrates information and logistics systems. Previous studies used the technology acceptance model (TAM), information systems (IS) success model, expectation confirmation model (ECM), or extended model to explain the continuance intention of traceability system users. Very little literature can be found integrating two different models to explain user intention, not to mention comparing three models in one research context. This study proposed the technology acceptance model (TAM), technology acceptance model-information systems (TAM-IS) success, and technology acceptance model-expectation confirmation model (TAM-ECM) integrated models to evaluate the most appropriate model to explain agri-food traceability system during the COVID-19 pandemic. A questionnaire was designed based on a literature review, and 197 agri-food traceability system users were sampled. The collected data were analyzed by partial least square (PLS) to understand the explanatory power and the differences between the three models. The results showed that: (1) the TAM model has a fair explanatory power of continuance intention (62.2%), but was recommended for its’ simplicity; (2) the TAM-IS success integrated model had the best predictive power of 78.3%; and (3) the system providers should raise users’ confirmation level, so their continuance intention could be reinforced through mediators, perceived value, and satisfaction. The above findings help to understand agri-food traceability system user intention, and provide theoretical and practical implications for system providers to refine their system design.
Sustainable Growth Drivers: Unveiling the Role Played by Carbon Productivity
Authors: Qi Wenhao , Song Changxing , Sun Meng , Wang Liguo , Han Youcheng
Published: January 2022

In global climate change, improving carbon productivity holds great importance for China’s sustainable growth. Based on panel data of 30 Chinese provinces and cities from 1997–2017, the drivers, spatial effects, and convergence characteristics of carbon productivity in China are explored by combining a factor decomposition framework and a spatial panel model. The findings show that (1) China’s carbon productivity shows continuous positive growth, and the substitution effect of capital for energy dominates this changing pattern; (2) There is a β-convergence trend and club convergence in China’s carbon productivity, and the spatial technology spillover accelerates the convergence rate; (3) With its accelerated industrial transformation and technological upgrading, China’s current carbon productivity converges faster than its earlier stage, and the role of physical capital investment has gradually shifted to suppression. In contrast, the positive push of human capital investment has been strengthened; (4) From the perspective of the realization mechanism, the convergence of carbon productivity in China mainly comes from the convergence of energy restructuring and capital-energy substitution. These findings can help China narrow the inter-provincial carbon productivity gap in terms of improving factor structure, upgrading technology, etc., and provide references for sustainable growth decision making in China and around the world.
Examination of the Prevalence of Female Athlete Triad Components among Competitive Cheerleaders
Authors: Smith Allison B. , Gay Jennifer L. , Arent Shawn M. , Sarzynski Mark A. , Emerson Dawn M. , Torres-McGehee Toni M.
Published: January 2022

The purpose of this study was to examine individual and combined Female Athlete Triad components within collegiate cheerleaders, an at-risk group. Cheerleaders (n = 19; age: 20.3 ± 1.2 years) completed anthropometric measurements, health history questionnaires, resting metabolic rate, the eating disorder inventory-3 and symptom checklist, blood sample, and DXA scan. Participants completed dietary and exercise logs for 7 days and used heart rate monitors to track daily and exercise energy expenditure. Proportions were calculated for low energy availability (LEA) risk, disordered eating risk, and pathogenic behaviors. Chi-square analysis was used to determine the difference between cheerleaders who experience low EA with or without disordered eating risk. All cheerleaders demonstrated LEA for the days they participated in cheerleading practice, 52.6% demonstrated LEA with eating disorder risk and 47.4% demonstrated LEA without eating disorder risk, 52.6% self-reported menstrual dysfunction, 14% experienced menstrual dysfunction via hormonal assessment, and 0% demonstrated low bone mineral density. Overall, 47.7% presented with one Triad component, 52.6% demonstrated two Triad components using self-reported menstrual data, and 10.5% demonstrated two Triad components using hormonal assessments. All cheerleaders displayed LEA. These findings support the need for increased education on the individual components of the Triad and their potential consequences by qualified personal.
The Role of Mindfulness in Business Administration (B.A.) University Students’ Career Prospects and Concerns about the Future
Authors: Plana-Farran Manel , Blanch Àngel , Solé Silvia
Published: January 2022

In a challenging work environment, entrepreneurship orientation (hereafter, EO) can be an important asset for university students. In this study, we investigated the EO and concerns about the future of B.A. students, focusing on the role of mindfulness levels. A total of 204 students, including those coming from family businesses (hereafter, FB), were asked about their intention of creating their own business and future concerns with an ad hoc questionnaire, and about their mindfulness levels with the Mindful Attention Awareness Scale. The results showed no differences in concerns about the future between those students coming from a family business and those who did not. However, in that group of students who were uncertain about starting a business career, a negative association between mindfulness and future concerns was found. This paper sheds light on the relationship between mindfulness and concerns about the future in Business Administration (hereafter, B.A.) students, concluding that, in the face of uncertainty, higher levels of mindfulness help to reduce concerns about the future. Finally, we indicate the relevance of this study for entrepreneurs, family business members, policymakers and B.A. Faculties and Business schools.
They Told Me “This Isn’t a Hotel”: Young People’s Experiences and Perceptions of Care When Presenting to the Emergency Department with Suicide-Related Behaviour
Authors: Freeman Jacinta , Strauss Penelope , Hamilton Sharynne , Pugh Charlotte , Browne Katherine , Caren Suzanne , Harris Chris , Millett Lyn , Smith Warwick , Lin Ashleigh
Published: January 2022

In Australia, the number of young people presenting to the emergency department with mental health concerns, in particular, suicidal behaviour (defined here as suicidal ideation, thoughts, intent and attempts) is increasing. Little is known about the experiences of Australian young people who present to hospital emergency departments with suicidal behaviour. In this qualitative study, we conducted a series of focus groups with 55 young people aged 16–25 years, with a view to developing a framework for youth suicide prevention for Western Australia. The data were analysed using a general inductive analysis approach. We explored the experiences and perceptions of the care and management of 35 young people presenting to Western Australian hospital emergency departments. Participants described a range of negative experiences relating to the emergency department environment, staff attitudes and their treatment by staff. We argue that adapting ED practices and approaches to young people presenting with suicidal thoughts and behaviours based on these findings will result in lower rates of repeated presentations and admissions to hospital and lower rates of suicide attempts and deaths by suicide.
Geographic and Ethnic Variations in Serum Concentrations of Legacy Persistent Organic Pollutants among Men in the Nenets Autonomous Okrug, Arctic Russia
Authors: Varakina Yulia , Aksenov Andrey , Lakhmanov Dmitry , Trofimova Anna , Korobitsyna Rimma , Belova Natalia , Kotsur Dmitry , Sorokina Tatiana , Grjibovski Andrej M. , Popova Ludmila , Chashchin Valery , Odland Jon Øyvind , Thomassen Yngvar
Published: January 2022

The overwhelming majority of Arctic biomonitoring studies in humans include either pregnant or non-pregnant women of reproductive age while little attention is paid to toxic compounds concentrations in men. This study contributes with information of the present amounts of persistent organic pollutants (POPs) in men living in Arctic Russia. We studied the serum concentrations of 11 polychlorinated biphenyl (PCB) congeners and 17 organochlorine pesticides (OCPs) and some of their metabolites in samples collected from 92 adult men (mean age 43 years) from seven different settlements in Nenets Autonomous Okrug (NAO). The median concentrations of individual PCB congeners increased in the order PCB 183, PCB 180, PCB 118, PCB 138, PCB 153. The concentrations of o, p′-DDD, p, p′-DDD, aldrin, mirex and 1,2,3,5-TCB were in most cases below the quantification limit. The observed concentrations of PCBs and chlorinated pesticides were in the same range as those found in similar groups of women of these territories, but lower than of men in other Arctic countries. However, significant geographic differences between the settlements were observed with exceptionally high concentrations of PCBs in the Islands group. The highest serum ∑PCBs and β-HCH levels were observed in adult males aged 60–78 years. We found significant variations in serum concentrations of POPs across settlements and ethnic groups with exceptionally high concentrations of PCBs among the residents of the Arctic islands. At the same time, our findings suggest a considerable decrease in serum concentration of POPs over the last decade.
Nighttime Walking with Music: Does Music Mediate the Influence of Personal Distress on Perceived Safety?
Authors: Yoo Ga Eul , Hong Sung Jin , Chong Hyun Ju
Published: January 2022

There is growing interest in identifying the environmental factors that contribute to individuals’ perceptions of safety and sense of well-being in public spaces. As such, this study examined how music listening during nighttime walking influenced female university students’ psychological state and perceptions of their campus. A total of 178 female university students with a mean age of 23.0 years participated in this study. One group of 78 students listened to prerecorded music while walking across their campus at night, while the other 100 students did not listen to music during nighttime walking. Immediately following their nighttime walking, participants were asked to rate their psychological state, perceptions on the safety of their campus, and the music (only for the music-listening group). For the non-music-listening group, significant correlations were found between the perceived safety of the campus and psychological states (both anxiety and psychological distress); the correlations were not significant in the music-listening group. The results indicate that music can mediate psychological states, supporting the proactive use of music as a psychological resource for coping with their perceptions of adverse environments. Given the limitations of this preliminary study, further studies with controlled music listening conditions, type of music, and environmental issues are suggested.
Can Hip-Knee Line Angle Distinguish the Size of Pelvic Incidence?—Development of Quick Noninvasive Assessment Tool for Pelvic Incidence Classification
Authors: Yamada Shota , Ebara Takeshi , Uehara Toru , Matsuki Taro , Kimura Shingo , Satsukawa Yuya , Yoshihara Akira , Aoki Kazuji , Inada Atsushi , Kamijima Michihiro
Published: January 2022

This study aimed to explore effective measurement angles for pelvic incidence (PI) classification and to develop a quick, noninvasive assessment tool for PI classification. We defined five variation types of hip–knee line (HKL) angles and tested the discrimination ability of the receiver operating characteristic (ROC) analysis using 125 photographs of upright standing posture from the right lateral side. ROC analysis revealed an applicable HKL angle defined by the line connecting the most raised part of the buttock and the central point of the knee and the midthigh line. The acceptable cut-off points for discriminating small or large PIs in terms of HKL angle were 18.5° for small PI (sensitivity, 0.91; specificity, 0.79) and 21.5° for large PI discrimination (sensitivity, 0.74; specificity, 0.72). In addition, we devised a quick noninvasive assessment tool for PI classification using the cut-offs of the HKL angle with a view to practical application. The results of intra- and inter-rater reliability ensured a substantial/moderate level of the tool (Cohen’s kappa coefficient, 0.79; Fleiss’s kappa coefficient, 0.50–0.54). These results revealed that the HKL angle can distinguish the size of the PI with a high/moderate discrimination ability. Furthermore, the tool indicated acceptable inter-/intra-rater reliability for practical applications.
The Relationship between Empathy and Attachment in Children and Adolescents: Three-Level Meta-Analyses
Authors: Xu Xizheng , Liu Zhiqiang , Gong Shaoying , Wu Yunpeng
Published: January 2022

Empathy is one of the leading social abilities to understand or feel the emotions of other people. Attachment is thought to be a critical influential factor of empathy, as revealed by attachment theory and experimental studies, while empathy is also believed to facilitate the quality of attachment. Although many studies are conducted concerning the two subjects, the direction and magnitude of their relationship still remain unclear. In order to clarify the discrepant results in the previous study and explore the moderators in the empathy–attachment association, three-level meta-analyses were conducted in the present work. Based on 212 effect sizes from 59 samples in 50 studies with a total of 24,572 participants, random effect model analyses showed that empathy was insignificantly correlated with anxious attachment, significantly negatively correlated with avoidant attachment, and significantly positively correlated with secure attachment. The meta-analytic results indicated that children and adolescents with high secure attachment tend to show more empathy than those with low secure attachment. The meta-regression model revealed significant effects of the empathy dimension, culture, empathy measurement tools, and publication state. Additionally, implications and future directions for the empathy–attachment relationship were also discussed.
Spatial Differences in the Effect of Communities’ Built Environment on Residents’ Health: A Case Study in Wuhan, China
Authors: Yuan Man , Pan Haolan , Shan Zhuoran , Feng Da
Published: January 2022

After 40 years of reform and opening-up policies, urbanization in China has significantly improved residents’ living standards; however, simultaneously, it has caused a series of health problems among Chinese citizens. Communities’ built environment is closely related to their residents’ health. However, few studies have examined the spatial differences in the health effects of community-built environments. Based on a 2013 health survey of residents in 20 communities in Wuhan, this study uses multilevel linear models to explore the effects of the built environment on residents’ health, analyzing the differences in its health-effect within different types of communities. The results showed that there were significant differences in the self-rated health status of residents in different communities, with those in high-end communities reporting a higher self-rated health status. The effect of the built environment on the health of residents in different communities was found to be inconsistent. For instance, the effect of the built environment on low-end community residents was very significant, but it was not obvious for residents in high-end communities. There are significant community-specific differences in the health- effect of the built environment: in high-end communities, residents’ health status was mainly restricted by travel accessibility, while in low-end communities, residents’ health status was mainly restricted by the accessibility of health facilities. Therefore, this paper proposes a built-environment optimization strategy for different types of communities to provide valuable insights for healthy community planning from a policy perspective.
Distribution Characteristics and Risk Assessment of Agricultural Land Use Non-Point Source Pollution in Typical Biofuel Ethanol Planting Areas
Authors: Cui Guannan , Liu Yanfeng , Wang Pengfei , Bai Xinyu , Wang Haitao , Xu Yiming , Yang Meiqiong , Dong Liming
Published: January 2022

Speeding up the promotion and application of bio-fuel ethanol was a national strategy in China, which in turn affected changes in the raw material planting structure. This study analyzed the distribution of nitrogen and phosphorus forms in water bodies and the soil of the typical maize and cassava fuel ethanol raw material planting areas. The results revealed that the maize planting area faced more serious TN and TP pollution. The river pollution was greatly affected by TN, TP, Ex-P and Fe/Al-P in soil, while soil TN and NO3−-N were the main factors influencing its counterpart. Furthermore, the risk assessment of soil nitrogen and phosphorus loss was carried out based on planting structures of crops. We investigated whether the water quality indexes or soil nitrogen and phosphorus loss risk assessment results showed that the Yujiang River stayed significantly less polluted. It was proven that the cassava planting area was more suitable for vigorously developing fuel ethanol. As for the high-risk areas, ecological agriculture promoting and fertilizer controlling measures were suggested. Under the change of the fuel-ethanol policy, this study could provide scientific support for the assessment of the impact of the Chinese national fuel ethanol policy on the water environment of the raw material planting area.
Assessment and Mapping Soil Water Erosion Using RUSLE Approach and GIS Tools: Case of Oued el-Hai Watershed, Aurès West, Northeastern of Algeria
Authors: Bensekhria Aida , Bouhata Rabah
Published: January 2022

The problem of soil water erosion is one of the primary causes of agro-pedological heritage degradation. The combined effect of natural factors and inappropriate human actions has weakened the soil, which seriously threatens the region’s fertile lands and soils, which can ultimately lead to an irreversible situation of desertification. This study focuses on analysis and mapping of the vulnerability to erosion in Oued el-Hai watershed, Algeria, based on a technical methodology that combines the universal soil loss equation (USLE) with the geographic information system (GIS) tools. The results are organized into three main classes of different rate values, from one area to another, depending on the influence of different factors that control the erosion process. The highest loss rate value is greater than 30 t·ha−1·yr−1 and covers 23.2% of the total area, mainly located in the mountainous areas with steep slopes. However, the minimum potential erosion rate value is mainly located on the plain, with an average of 10 t·ha−1·yr−1 covering 45.2% of the total area of the watershed. The estimate of potential water erosion has given alarming results. The total area of the watershed could lose a rate of 16.69 t·ha−1·yr−1 (on average) each year. The method and results described in this article are valuable for understanding the soil erosion risk and are useful for managing and planning land use that will avoid land degradation. Hence, the results of this study are considered an important document which constitutes a decision support tool in terms of the management and protection of natural resources.
Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative
Authors: Wu Alexander T. H. , Lawal Bashir , Tzeng Yew-Min , Shih Chun-Che , Shih Chun-Ming
Published: January 2022

Myocardial infarction (MI) is a multifactorial global disease, recognized as one of the leading causes of cardiovascular morbidity and mortality. Timely and correct diagnoses and effective treatments could significantly reduce incidence of complications and improve patient prognoses. In this study, seven unconventional differentially expressed genes (DEGs) (MAN2A2, TNFRSF12A, SPP1, CSNK1D, PLAUR, PFKFB3, and CXCL16, collectively termed the MTSCPPC signature) were identified through integrating DEGs from six MI microarray datasets. The pathological and theranostic roles of the MTSCPPC signature in MI were subsequently analyzed. We evaluated interactions of the MTSCPPC signature with ovatodiolide, a bioactive compound isolated from Anisomeles indica (L.) Kuntze, using in silico molecular docking tools and compared it to specific inhibitors of the members of the MTSCPPC signature. Single-cell transcriptomic analysis of the public databases revealed high expression levels of the MTSCPPC signature in immune cells of adult human hearts during an MI event. The MTSCPPC signature was significantly associated with the cytokine–cytokine receptor interactions, chemokine signaling, immune and inflammatory responses, and metabolic dysregulation in MI. Analysis of a micro (mi)RNA regulatory network of the MTSCPPC signature suggested post-transcriptional activation and the roles of miRNAs in the pathology of MI. Our molecular docking analysis suggested a higher potential for ovatodiolide to target MAN2A2, CSNK1D, and TNFRSF12A. Collectively, the results derived from the present study further advance our understanding of the complex regulatory mechanisms of MI and provide a potential MI theranostic signature with ovatodiolide as a therapeutic candidate.
Medicated Scaffolds Prepared with Hydroxyapatite/Streptomycin Nanoparticles Encapsulated into Polylactide Microfibers
Authors: Kadkhodaie-Elyaderani Amirmajid , de Lama-Odría Maria del Carmen , Rivas Manuel , Martínez-Rovira Immaculada , Yousef Ibraheem , Puiggalí Jordi , del Valle Luis J.
Published: January 2022

The preparation, characterization, and controlled release of hydroxyapatite (HAp) nanoparticles loaded with streptomycin (STR) was studied. These nanoparticles are highly appropriate for the treatment of bacterial infections and are also promising for the treatment of cancer cells. The analyses involved scanning electron microscopy, dynamic light scattering (DLS) and Z-potential measurements, as well as infrared spectroscopy and X-ray diffraction. Both amorphous (ACP) and crystalline (cHAp) hydroxyapatite nanoparticles were considered since they differ in their release behavior (faster and slower for amorphous and crystalline particles, respectively). The encapsulated nanoparticles were finally incorporated into biodegradable and biocompatible polylactide (PLA) scaffolds. The STR load was carried out following different pathways during the synthesis/precipitation of the nanoparticles (i.e., nucleation steps) and also by simple adsorption once the nanoparticles were formed. The loaded nanoparticles were biocompatible according to the study of the cytotoxicity of extracts using different cell lines. FTIR microspectroscopy was also employed to evaluate the cytotoxic effect on cancer cell lines of nanoparticles internalized by endocytosis. The results were promising when amorphous nanoparticles were employed. The nanoparticles loaded with STR increased their size and changed their superficial negative charge to positive. The nanoparticles’ crystallinity decreased, with the consequence that their crystal sizes reduced, when STR was incorporated into their structure. STR maintained its antibacterial activity, although it was reduced during the adsorption into the nanoparticles formed. The STR release was faster from the amorphous ACP nanoparticles and slower from the crystalline cHAp nanoparticles. However, in both cases, the STR release was slower when incorporated in calcium and phosphate during the synthesis. The biocompatibility of these nanoparticles was assayed by two approximations. When extracts from the nanoparticles were evaluated in cultures of cell lines, no cytotoxic damage was observed at concentrations of less than 10 mg/mL. This demonstrated their biocompatibility. Another experiment using FTIR microspectroscopy evaluated the cytotoxic effect of nanoparticles internalized by endocytosis in cancer cells. The results demonstrated slight damage to the biomacromolecules when the cells were treated with ACP nanoparticles. Both ACP and cHAp nanoparticles were efficiently encapsulated in PLA electrospun matrices, providing functionality and bioactive properties.
Undifferentiated Sarcomatoid Carcinoma of the Pancreas: From Histology and Molecular Pathology to Precision Oncology
Authors: Gkountakos Anastasios , Simbolo Michele , Bariani Elena , Scarpa Aldo , Luchini Claudio
Published: January 2022

Undifferentiated sarcomatoid carcinoma of the pancreas (SCP) is a rare and aggressive subtype of pancreatic cancer. Histologically, SCP is a poorly differentiated tumor characterized by the lack of glandular differentiation and the presence of mesenchymal-like, spindle-shaped tumor cells. Due to its rarity, only sporadic cases have been reported, while its molecular characterization has not been sufficiently described. Surgical resection with curative intent is the gold-standard of SCP management, but this strategy is possible only in a small proportion of cases due to SCP early metastasization. Although SCP is generally associated with a poor prognosis, some clinical cases amenable to surgical resection and followed by adjuvant chemotherapy have demonstrated a remarkably long survival. Preliminary molecular insights on the SCP molecular landscape have demonstrated the recurrent presence of KRAS and TP53 mutations, highlighting genetic similarities with conventional pancreatic ductal adenocarcinoma (PDAC). Although the use of immunotherapy in PDAC remains an unmet challenge, recent insights indicated a potentially significant role of the PD-L1/Notch3 axis in SCP, opening new horizons for immunotherapy in this cancer subtype. In this review, we described the most important clinic-pathologic features of SCP, with a specific focus on their molecular landscape and the potential targets for precision oncology.
LCZ696 Protects against Diabetic Cardiomyopathy-Induced Myocardial Inflammation, ER Stress, and Apoptosis through Inhibiting AGEs/NF-κB and PERK/CHOP Signaling Pathways
Authors: Belali Osamah M. , Ahmed Mohammed M. , Mohany Mohamed , Belali Tarig M. , Alotaibi Meshal M. , Al-Hoshani Ali , Al-Rejaie Salim S.
Published: January 2022

The present study is designed to determine the effect of LCZ696 on DCM in rats and investigate the underlying mechanism involved. Diabetes was induced by feeding rats with a high-fat diet for six weeks following a single injection of STZ (30 mg/kg). Diabetic rats were divided into three groups (n = 10). LCZ696 and valsartan treatment was started two weeks after diabetic induction and continued for eight weeks. At the end of the treatment, serum and cardiac tissues were analyzed by RT-PCR, Western blot, and ELISA kits. LCZ696 and valsartan ameliorated DCM progression by inhibiting AGEs formation at activity levels; pro-apoptotic markers (BAX/Bcl2 ratio and caspase-3) in mRNA and protein expressions, the NF-κB at mRNA; and protein levels associated with the restoration of elevated proinflammatory cytokines such as the TNF-α, IL-6, and IL-1β at the activity level. Furthermore, LCZ696 and valsartan contribute to restoring the induction of ER stress parameters (GRP78, PERK, eIF2a, ATF4, and CHOP) at mRNA and protein levels. LCZ696 and valsartan attenuated DCM by inhibiting the myocardial inflammation, ER stress, and apoptosis through AGEs/NF-κB and PERK/CHOP signaling cascades. Collectively, the present results reveal that LCZ696 had a more protective solid effect against DCM than valsartan.
Shape-Memory Polymers Hallmarks and Their Biomedical Applications in the Form of Nanofibers
Authors: Pisani Silvia , Genta Ida , Modena Tiziana , Dorati Rossella , Benazzo Marco , Conti Bice
Published: January 2022

Shape-Memory Polymers (SMPs) are considered a kind of smart material able to modify size, shape, stiffness and strain in response to different external (heat, electric and magnetic field, water or light) stimuli including the physiologic ones such as pH, body temperature and ions concentration. The ability of SMPs is to memorize their original shape before triggered exposure and after deformation, in the absence of the stimulus, and to recover their original shape without any help. SMPs nanofibers (SMPNs) have been increasingly investigated for biomedical applications due to nanofiber’s favorable properties such as high surface area per volume unit, high porosity, small diameter, low density, desirable fiber orientation and nanoarchitecture mimicking native Extra Cellular Matrix (ECM). This review focuses on the main properties of SMPs, their classification and shape-memory effects. Moreover, advantages in the use of SMPNs and different biomedical application fields are reported and discussed.
Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries
Authors: Enserink Jorrit M. , Chymkowitch Pierre
Published: January 2022

The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle. However, studies conducted several decades ago with mammalian cells revealed that Cdk1 also directly regulates the basal transcription machinery, most notably RNA polymerase II. More recent studies in the budding yeast Saccharomyces cerevisiae have revisited this function of Cdk1 and also revealed that Cdk1 directly controls RNA polymerase III activity. These studies have also provided novel insight into the physiological relevance of this process. For instance, cell cycle-stage-dependent activity of these complexes may be important for meeting the increased demand for various proteins involved in housekeeping, metabolism, and protein synthesis. Recent work also indicates that direct regulation of the RNA polymerase II machinery promotes cell cycle entry. Here, we provide an overview of the regulation of basal transcription by Cdk1, and we hypothesize that the original function of the primordial cell-cycle CDK was to regulate RNAPII and that it later evolved into specialized kinases that govern various aspects of the transcription machinery and the cell cycle.