bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulsed-chaos MIMO radar based on a single flat-spectrum and Delta-like autocorrelation optical chaos source
Authors: Feng Weizhou , Jiang Ning , Zhang Yiqun , Jin Jiaoyang , Zhao Anke , Liu Shiqin , Qiu Kun
Published: January 2022

We propose and demonstrate a pulsed-chaos multiple-input-multiple-output (MIMO) radar system in this paper. In the proposed MIMO radar system, multi-channel pulsed chaotic signals are extracted from an optical seed chaos source with Delta-like autocorrelation and flat spectrum. The seed chaos source is generated by passing the chaotic output of an external-cavity semiconductor laser through a dispersive self-feedback phase-modulation loop and used for MIMO radar signal generation. The cross-correlation characteristics of MIMO radar signals, the maximum channel number of separable mixed echoes, as well as the performances of multi-target ranging and anti-interference in the proposed pulsed-chaos MIMO radar system are systematically investigated. The results indicate that multi-channel pulsed-chaos signals with Delta-like autocorrelation can be simultaneously generated from the seed chaos source, and excellent quasi-orthogonality of transmission radar signals can be guaranteed. Moreover, it is demonstrated that the proposed pulsed-chaos MIMO radar supports multi-target ranging with a centimeter-level resolution and can maintain satisfactory performance under low SNR scenarios with various interferences.
Large depth-of-field fluorescence microscopy based on deep learning supported by Fresnel incoherent correlation holography
Authors: Wu Peng , Zhang Dejie , Yuan Jing , Zeng Shaoqun , Gong Hui , Luo Qingming , Yang Xiaoquan
Published: January 2022

Fluorescence microscopy plays an irreplaceable role in biomedicine. However, limited depth of field (DoF) of fluorescence microscopy is always an obstacle of image quality, especially when the sample is with an uneven surface or distributed in different depths. In this manuscript, we combine deep learning with Fresnel incoherent correlation holography to describe a method to obtain significant large DoF fluorescence microscopy. Firstly, the hologram is restored by the Auto-ASP method from out-of-focus to in-focus in double-spherical wave Fresnel incoherent correlation holography. Then, we use a generative adversarial network to eliminate the artifacts introduced by Auto-ASP and output the high-quality image as a result. We use fluorescent beads, USAF target and mouse brain as samples to demonstrate the large DoF of more than 400µm, which is 13 times better than that of traditional wide-field microscopy. Moreover, our method is with a simple structure, which can be easily combined with many existing fluorescence microscopic imaging technology.
On-chip silicon switchable polarization beam splitter
Authors: Yin Shaojie , Qiu Huaqing , Wang Zhibin , Dai Daoxin , Guan Xiaowei
Published: January 2022

We propose and experimentally demonstrate an on-chip switchable polarization beam splitter (PBS) using silicon waveguides. To the best of our knowledge, it is the first demonstration of an on-chip PBS that is not only able to split polarization beams but can be tuned to allow these beams to switch the output paths. The design of the switchable PBS is based on a directional coupler. Measurements show extinction ratios of >12 dB in both the initial state and the switched state, which is realized by heating the device up to 57°C. By adding switching ability to an on-chip PBS, this work is expected to benefit quantum technology, communications, microwave photonics, etc.
Dominating lengthscales of zebrafish collective behaviour
Authors: Yang Yushi , Turci Francesco , Kague Erika , Hammond Chrissy L. , Russo John , Royall C. Patrick
Published: January 2022

Collective behaviour in living systems is observed across many scales, from bacteria to insects, to fish shoals. Zebrafish have emerged as a model system amenable to laboratory study. Here we report a three-dimensional study of the collective dynamics of fifty zebrafish. We observed the emergence of collective behaviour changing between ordered to randomised, upon adaptation to new environmental conditions. We quantify the spatial and temporal correlation functions of the fish and identify two length scales, the persistence length and the nearest neighbour distance, that capture the essence of the behavioural changes. The ratio of the two length scales correlates robustly with the polarisation of collective motion that we explain with a reductionist model of self–propelled particles with alignment interactions.
A short plus long-amplicon based sequencing approach improves genomic coverage and variant detection in the SARS-CoV-2 genome
Authors: Arana Carlos , Liang Chaoying , Brock Matthew , Zhang Bo , Zhou Jinchun , Chen Li , Cantarel Brandi , SoRelle Jeffrey , Hooper Lora V. , Raj Prithvi
Published: January 2022

High viral transmission in the COVID-19 pandemic has enabled SARS‐CoV‐2 to acquire new mutations that may impact genome sequencing methods. The ARTIC.v3 primer pool that amplifies short amplicons in a multiplex-PCR reaction is one of the most widely used methods for sequencing the SARS-CoV-2 genome. We observed that some genomic intervals are poorly captured with ARTIC primers. To improve the genomic coverage and variant detection across these intervals, we designed long amplicon primers and evaluated the performance of a short (ARTIC) plus long amplicon (MRL) sequencing approach. Sequencing assays were optimized on VR-1986D-ATCC RNA followed by sequencing of nasopharyngeal swab specimens from fifteen COVID-19 positive patients. ARTIC data covered 94.47% of the virus genome fraction in the positive control and patient samples. Variant analysis in the ARTIC data detected 217 mutations, including 209 single nucleotide variants (SNVs) and eight insertions & deletions. On the other hand, long-amplicon data detected 156 mutations, of which 80% were concordant with ARTIC data. Combined analysis of ARTIC + MRL data improved the genomic coverage to 97.03% and identified 214 high confidence mutations. The combined final set of 214 mutations included 203 SNVs, 8 deletions and 3 insertions. Analysis showed 26 SARS-CoV-2 lineage defining mutations including 4 known variants of concern K417N, E484K, N501Y, P618H in spike gene. Hybrid analysis identified 7 nonsynonymous and 5 synonymous mutations across the genome that were either ambiguous or not called in ARTIC data. For example, G172V mutation in the ORF3a protein and A2A mutation in Membrane protein were missed by the ARTIC assay. Thus, we show that while the short amplicon (ARTIC) assay provides good genomic coverage with high throughput, complementation of poorly captured intervals with long amplicon data can significantly improve SARS-CoV-2 genomic coverage and variant detection.
Environmental regulation and corporate tax avoidance—Evidence from China
Authors: Yang Xiaokang , Xu Junbing , Zhu Minling , Yang Yinglong
Published: January 2022

In this study, we used a difference-in-difference (DID) approach to analyze the effect of environmental regulation on corporate tax avoidance behavior based on China’s carbon emissions trading pilot policy of 2013. Our findings were as follows: (1) Environmental regulation has led companies to adopt further tax evasion behaviors. Furthermore, the core conclusion was confirmed after a series of robust and endogenous tests, such as parallel trends and PSM-DID (propensity score matching-difference-in-difference). (2) Environmental regulations increase tax avoidance activities by reducing corporate cash flows. (3) The influence of environmental regulation on firm tax evasion is highly pronounced among non-state-owned enterprises, big-scale enterprises, and enterprises with a high degree of industry competition.
Quarantine-related traumatic stress, views, and experiences during the first wave of Coronavirus pandemic: A mixed-methods study among adults in Saudi Arabia
Authors: Bin Helayel Halah , Ahmed Anwar , Ahmed Syed Khabir , Ahmad Abeer , Khan Ruhi , Al-Swailem Samar A.
Published: January 2022

Purpose

Mental health is a significant problem following exposure to a traumatic event. This study aimed to examine quarantine-related experiences, traumatic stress, and coping strategies among adults quarantined in Saudi Arabia due to coronavirus disease 2019 (COVID-19) exposure or travel history.

Methods

Individuals aged ≥ 18 years who were quarantined in Saudi Arabia due to COVID-19 exposure or travel history were included. We used a sequential mixed methods design, using an online survey followed by in-depth individual telephonic interviews. The Impact of Event Scale-Revised (IES–R) was used to measure post-traumatic stress disorder (PTSD) symptoms after the quarantine. To identify factors associated with significant symptoms (IES–R score ≥ 33), prevalence ratios (PR) with 95% confidence intervals were computed using Poisson regression with robust error variance. In the next phase, a subset of the participants (n = 26) were interviewed to elicit their quarantine-related experiences and coping responses. Major themes and subthemes were identified.

Results

Of the 111 adults who completed the survey, 32 (28.8% [95% CI, 21.1–38.0%]) had significant PTSD symptoms (IES–R score ≥ 33) and 27 (24.3% [95% CI, 17.2–33.3%]) had severe symptoms (IES–R score > 37). Marital status was the only variable that was significantly associated with significant PTSD symptoms (P = 0.028). Significant symptoms were twice as prevalent in married adults than among other marital groups (PR 2.00, 95% CI, 1.08–3.72). Participants reported negative emotions such as overwhelming fear, helplessness, anxiety, and disgust. Participants utilized both problem-centered coping (e.g., use of social support) and emotion-centered coping (e.g., use of positive diversionary activities) during the quarantine period.

Conclusion

PTSD symptoms were present in one out of every four quarantined persons. The quarantine experience is viewed negatively. These findings highlight the need for increased awareness about stress-related disorders among quarantined individuals. Efforts are needed to detect and manage these symptoms early while making the quarantine experience more satisfying for the involved individuals and groups.
miR-27a-3p regulates expression of intercellular junctions at the brain endothelium and controls the endothelial barrier permeability
Authors: Harati Rania , Hammad Saba , Tlili Abdelaziz , Mahfood Mona , Mabondzo Aloïse , Hamoudi Rifat
Published: January 2022

Background

The brain endothelial barrier permeability is governed by tight and adherens junction protein complexes that restrict paracellular permeability at the blood-brain barrier (BBB). Dysfunction of the inter-endothelial junctions has been implicated in neurological disorders such as multiple sclerosis, stroke and Alzheimer’s disease. The molecular mechanisms underlying junctional dysfunction during BBB impairment remain elusive. MicroRNAs (miRNAs) have emerged as versatile regulators of the BBB function under physiological and pathological conditions, and altered levels of BBB-associated microRNAs were demonstrated in a number of brain pathologies including neurodegeneration and neuroinflammatory diseases. Among the altered micro-RNAs, miR-27a-3p was found to be downregulated in a number of neurological diseases characterized by loss of inter-endothelial junctions and disruption of the barrier integrity. However, the relationship between miR-27a-3p and tight and adherens junctions at the brain endothelium remains unexplored. Whether miR-27a-3p is involved in regulation of the junctions at the brain endothelium remains to be determined.

Methods

Using a gain-and-loss of function approach, we modulated levels of miR-27a-3p in an in-vitro model of the brain endothelium, key component of the BBB, and examined the resultant effect on the barrier paracellular permeability and on the expression of essential tight and adherens junctions. The mechanisms governing the regulation of junctional proteins by miR-27a-3p were also explored.

Results

Our results showed that miR-27a-3p inhibitor increases the barrier permeability and causes reduction of claudin-5 and occludin, two proteins highly enriched at the tight junction, while miR-27a-3p mimic reduced the paracellular leakage and increased claudin-5 and occludin protein levels. Interestingly, we found that miR-27-3p induces expression of claudin-5 and occludin by downregulating Glycogen Synthase Kinase 3 beta (GSK3ß) and activating Wnt/ß-catenin signaling, a key pathway required for the BBB maintenance.

Conclusion

For the first time, we showed that miR-27a-3p is a positive regulator of key tight junction proteins, claudin-5 and occludin, at the brain endothelium through targeting GSK3ß gene and activating Wnt/ß-catenin signaling. Thus, miR-27a-3p may constitute a novel therapeutic target that could be exploited to prevent BBB dysfunction and preserves its integrity in neurological disorders characterized by impairment of the barrier’s function.
Efficacy of Fluorecare SARS-CoV-2 Spike Protein Test Kit for SARS-CoV-2 detection in nasopharyngeal samples of 121 individuals working in a manufacturing company
Authors: Tonelotto Valentina , Davini Annamaria , Cardarelli Laura , Calderone Milena , Marin Paola
Published: January 2022

Objectives

The aim of this study was to evaluate the clinical performance of the Fluorecare SARS-CoV-2 Spike Protein Test Kit, a rapid immunochromatographic assay for SARS-CoV-2 detection. Moreover, we sought to point out the strategy adopted by a local company to lift the lockdown without leading to an increase in the number of COVID-19 cases, by performing a precise and timely health surveillance.

Methods

The rapid Fluorecare SARS-CoV-2 Spike Protein Test was performed immediately after sampling following the manufacturer’s instructions. RT-PCRs were performed within 24 hours of specimen collection. A total amount of 253 nasopharyngeal samples from 121 individuals were collected between March 16 and April 2, 2021 and tested.

Results

Of 253 nasopharyngeal samples, 11 (9.1%) were positive and 242 (90.9%) were negative for SARS-CoV-2 RNA by RT-PCR assays. The rapid SARS-CoV-2 antigen detection test’s mean sensitivity and specificity were 84,6% (95% CI, 54.6–98.1%) and 100% (95% CI, 98.6–100%), respectively. Two false negative test results were obtained from samples with high RT-PCR cycle threshold (Ct).

Conclusion

Our study suggested that Fluorecare SARS-CoV-2 Spike Protein Test can be introduced into daily diagnostic practice, as its mean sensitivity and specificity follow the standards recommended by WHO and IFCC Task Force. In addition, we underlined how the strategy adopted by a local company to risk assessment and health surveillance was appropriate for infection containment. This real-life scenario gave us the possibility to experience potential approaches aimed to preserve public health and work activities.
Does weight mediate the effect of smoking on coronary heart disease? Parametric mediational g-formula analysis
Authors: Mokhayeri Yaser , Nazemipour Maryam , Mansournia Mohammad Ali , Naimi Ashley I. , Kaufman Jay S.
Published: January 2022

Background

In settings in which there are time-varying confounders affected by previous exposure and a time-varying mediator, natural direct and indirect effects cannot generally be estimated unbiasedly. In the present study, we estimate interventional direct effect and interventional indirect effect of cigarette smoking as a time-varying exposure on coronary heart disease while considering body weight as a time-varying mediator.

Methods

To address this problem, the parametric mediational g-formula was proposed to estimate interventional direct effect and interventional indirect effect. We used data from the Multi-Ethnic Study of Atherosclerosis to estimate effect of cigarette smoking on coronary heart disease, considering body weight as time-varying mediator.

Results

Over a 11-years period, smoking 20 cigarettes per day compared to no smoking directly (not through weight) increased risk of coronary heart disease by an absolute difference of 1.91% (95% CI: 0.49%, 4.14%), and indirectly decreased coronary heart disease risk by -0.02% (95% CI: -0.05%, 0.04%) via change in weight. The total effect was estimated as an absolute 1.89% increase (95% CI: 0.49%, 4.13%).

Conclusion

The overall absolute impact of smoking to incident coronary heart disease is modest, and we did not discern any important contribution to this effect relayed through changes to bodyweight. In fact, changes in weight because of smoking have no meaningful mediating effect on CHD risk.
Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences
Authors: Nomikos Polykarpos Angelos , Hall Michelle C. , Fuller Amy , Ogollah Reuben , Valdes Ana M. , Doherty Michael , Walsh David Andrew , das Nair Roshan , Abhishek Abhishek
Published: January 2022

Objectives

The overall purpose of this research programme is to develop and test the feasibility of a complex intervention for knee pain delivered by a nurse, and comprising both non-pharmacological and pharmacological interventions. In this first phase, we examined the acceptability of the non-pharmacological component of the intervention; issues faced in delivery, and resolved possible challenges to delivery.

Methods

Eighteen adults with chronic knee pain were recruited from the community. The intervention comprised holistic assessment, education, exercise, weight-loss advice (where appropriate) and advice on adjunctive treatments such as hot/cold treatments, footwear modification and walking aids. After nurse training, the intervention was delivered in four sessions spread over five weeks. Participants had one to one semi-structured interview at the end of the intervention. The nurse was interviewed after the last visit of the last participant. These were audio recorded and transcribed verbatim. Themes were identified by one author through framework analysis of the transcripts, and cross-checked by another.

Results

Most participants found the advice from the nurse easy to follow and were satisfied with the package, though some felt that too much information was provided too soon. The intervention changed their perception of managing knee pain, learning that it can be improved with self-management. However, participants thought that the most challenging part of the intervention was fitting the exercise regime into their daily routine. The nurse found discussion of goal setting to be challenging.

Conclusion

The nurse-led package of care is acceptable within a research setting. The results are promising and will be applied in a feasibility randomised-controlled trial.
Test-retest reliability of the HEXACO-100—And the value of multiple measurements for assessing reliability
Authors: Henry Sam , Thielmann Isabel , Booth Tom , Mõttus René
Published: January 2022

Despite the widespread use of the HEXACO model as a descriptive taxonomy of personality traits, there remains limited information on the test-retest reliability of its commonly-used inventories. Studies typically report internal consistency estimates, such as alpha or omega, but there are good reasons to believe that these do not accurately assess reliability. We report 13-day test-retest correlations of the 100- and 60-item English HEXACO Personality Inventory-Revised (HEXACO-100 and HEXACO-60) domains, facets, and items. In order to test the validity of test-retest reliability, we then compare these estimates to correlations between self- and informant-reports (i.e., cross-rater agreement), a widely-used validity criterion. Median estimates of test-retest reliability were .88, .81, and .65 (N = 416) for domains, facets, and items, respectively. Facets’ and items’ test-retest reliabilities were highly correlated with their cross-rater agreement estimates, whereas internal consistencies were not. Overall, the HEXACO Personality Inventory-Revised demonstrates test-retest reliability similar to other contemporary measures. We recommend that short-term retest reliability should be routinely calculated to assess reliability.
The fewer, the better fare: Can the loss of vegetation in the Cerrado drive the increase in dengue fever cases infection?
Authors: Pereira da Silva Arlindo Ananias , Franquelino Adriano Roberto , Teodoro Paulo Eduardo , Montanari Rafael , Faria Glaucia Amorim , Ribeiro da Silva Cristóvão Henrique , Bortoloto da Silva Dayane , Júnior Walter Aparecido Ribeiro , Muchalak Franciele , Cruz Souza Kassia Maria , Prudencio da Silva Marcos Henrique , Teodoro Larissa Pereira Ribeiro
Published: January 2022

Several studies have reported the relationship of deforestation with increased incidence of infectious diseases, mainly due to the deregulation caused in these environments. The purpose of this study was to answer the following questions: a) is increased loss of vegetation related to dengue cases in the Brazilian Cerrado? b) how do different regions of the tropical savanna biome present distinct patterns for total dengue cases and vegetation loss? c) what is the projection of a future scenario of deforestation and an increased number of dengue cases in 2030? Thus, this study aimed to assess the relationship between loss of native vegetation in the Cerrado and dengue infection. In this paper, we quantify the entire deforested area and dengue infection cases from 2001 to 2019. For data analyses, we used Poisson generalized linear model, descriptive statistics, cluster analysis, non-parametric statistics, and autoregressive integrated moving average (ARIMA) models to predict loss of vegetation and fever dengue cases for the next decade. Cluster analysis revealed the formation of four clusters among the states. Our results showed significant increases in loss of native vegetation in all states, with the exception of Piauí. As for dengue cases, there were increases in the states of Minas Gerais, São Paulo, and Mato Grosso. Based on projections for 2030, Minas Gerais will register about 4,000 dengue cases per 100,000 inhabitants, São Paulo 750 dengue cases per 100,000 inhabitants, and Mato Grosso 500 dengue cases per 100,000 inhabitants. To reduce these projections, Brazil will need to control deforestation and implement public health, environmental and social policies, requiring a joint effort from all spheres of society.
The Symptom Burden and Quality of Life in Cancer Patients in the Gaza Strip, Palestine: A Cross-Sectional Study
Authors: ElMokhallalati Yousuf , Alaloul Enas , Shatat Mohammed , Shneewra Tasneem , El Massri Saad , Shaer Omar , Relton Samuel , Abu-Odah Hammoda , Allsop Matthew J.
Published: January 2022

Objectives

Cancer is the second leading cause of death in the Gaza Strip, Palestine, but there is an absence of evidence systematically assessing symptom burden and quality of life (QoL) using validated tools. Our objective was to assess associations between socio-demographic and disease-related characteristics, symptom burden and QoL in a sample of cancer patients accessing outpatient services in the Gaza Strip.

Design

A cross-sectional, descriptive survey using interviews and medical record review involving patients with cancer accessing oncology outpatient services at Al Rantisi Hospital and European Gaza Hospital (EGH) in the Gaza Strip was employed. Socio-demographic and disease-related data, the Lebanese version of the Memorial Symptom Assessment Scale (MSAS-Leb), and the Arabic version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) were collected. Multiple linear regression was used to judge the relative influence of determinants of QoL.

Results

Of 414 cancer patients approached, 385 patients consented to participation. The majority were women (64.7%) with a mean age of 52 years (SD = 16.7). Common cancer diagnoses were breast (32.2%), haematological (17.9%) and colorectal (9.1%). The median number of symptoms was 10 (IQR 1.5–18.5). Mean overall QoL was 70.5 (SD 19.9) with common physical and psychological symptoms identified. A higher burden of symptoms was associated with marital status, education and income. Limited access to both opioids and psychological support were reported.

Conclusions

A high symptom burden was identified in outpatients with cancer. Increasing provision and access to supportive care for physical and psychological symptoms should be prioritised alongside exploring routine assessment of symptom burden and QoL.
Trends of in-hospital cardiac arrests in a single tertiary hospital with a mature rapid response system
Authors: Jung Hohyung , Ko Ryoung-Eun , Ko Myeong Gyun , Jeon Kyeongman
Published: January 2022

Background

Most studies on rapid response system (RRS) have simply focused on its role and effectiveness in reducing in-hospital cardiac arrests (IHCAs) or hospital mortality, regardless of the predictability of IHCA. This study aimed to identify the characteristics of IHCAs including predictability of the IHCAs as our RRS matures for 10 years, to determine the best measure for RRS evaluation.

Methods

Data on all consecutive adult patients who experienced IHCA and received cardiopulmonary resuscitation in general wards between January 2010 and December 2019 were reviewed. IHCAs were classified into three groups: preventable IHCA (P-IHCA), non-preventable IHCA (NP-IHCA), and inevitable IHCA (I-IHCA). The annual changes of three groups of IHCAs were analyzed with Poisson regression models.

Results

Of a total of 800 IHCA patients, 149 (18.6%) had P-IHCA, 465 (58.1%) had NP-IHCA, and 186 (23.2%) had I-IHCA. The number of the RRS activations increased significantly from 1,164 in 2010 to 1,560 in 2019 (P = 0.009), and in-hospital mortality rate was significantly decreased from 9.20/1,000 patients in 2010 to 7.23/1000 patients in 2019 (P = 0.009). The trend for the overall IHCA rate was stable, from 0.77/1,000 patients in 2010 to 1.06/1,000 patients in 2019 (P = 0.929). However, while the incidence of NP-IHCA (P = 0.927) and I-IHCA (P = 0.421) was relatively unchanged over time, the incidence of P-IHCA decreased from 0.19/1,000 patients in 2010 to 0.12/1,000 patients in 2019 (P = 0.025).

Conclusions

The incidence of P-IHCA could be a quality metric to measure the clinical outcomes of RRS implementation and maturation than overall IHCAs.
Asthma control and its predictors in Ethiopia: Systematic review and meta-analysis
Authors: Mulugeta Temesgen , Ayele Teshale , Zeleke Getandale , Tesfay Gebremichael
Published: January 2022

Background

Determining the status of asthma control and identifying risk factors for poor asthma control is a key strategy for curbing the negative health impacts and the financial burden of the disease. Therefore, this review was aimed to determine the rate of asthma control and assess the predictors of uncontrolled asthma in Ethiopia.

Methods

PubMed, Web of Science, and Google Scholar searches were performed using key terms; “asthma, bronchial asthma, control, controlled, uncontrolled and Ethiopia” up to October 16, 2020. University repositories were also searched to retrieve gray literature. The results were presented as a prevalence rate with a 95% confidence interval (CI). Subgroup analysis and meta-regression were performed to identify the sources of heterogeneity in the outcomes.

Results

From 1,388 patients, based on the Global Initiative for Asthma (GINA) symptom control, the rate of the uncontrolled asthma was 45.0% (95% CI 34.0% - 56.0%) with a considerable heterogeneity between the studies; (I2: 94.55, p< 0.001). About 19.0% (95% CI 10.0% - 29.0%); (I2: 96.04, p< 0.001) of the asthma patients had a well-controlled asthma. Moreover, 36.0% (95% CI 22.0% - 50.0%), (I2: 97.11, p< 0.001) of patients had a partly controlled asthma. Similarly, based on the asthma control test (ACT), the rate of well-controlled asthma was 22.0% (95% CI 3% - 42.0%), with considerable heterogeneity between the studies; (I2: 97.75, p< 0.001). The most frequent predictors of uncontrolled asthma were incorrect inhalation techniques, frequent SABA use, moderate/severe persistent asthma, history of exacerbations, presence of comorbidities, use of oral corticosteroids, and irregular follow-up.

Conclusion

The rate of uncontrolled asthma in Ethiopia was high. Several factors are associated with uncontrolled asthma. Comprehensive asthma educations at each follow-up visit should be strengthened to minimize the morbidity and the cost of uncontrolled asthma.
Prevalence and antimicrobial resistance pattern of Clostridium difficile among hospitalized diarrheal patients: A systematic review and meta-analysis
Authors: Dilnessa Tebelay , Getaneh Alem , Hailu Workagegnehu , Moges Feleke , Gelaw Baye
Published: January 2022

Background

Clostridium difficile is the leading cause of infectious diarrhea that develops in patients after hospitalization during antibiotic administration. It has also become a big issue in community-acquired diarrhea. The emergence of hypervirulent strains of C. difficile poses a major problem in hospital-associated diarrhea outbreaks and it is difficult to treat. The antimicrobial resistance in C. difficile has worsened due to the inappropriate use of broad-spectrum antibiotics including cephalosporins, clindamycin, tetracycline, and fluoroquinolones together with the emergence of hypervirulent strains.

Objective

To estimate the pooled prevalence and antimicrobial resistance pattern of C. difficile derived from hospitalized diarrheal patients, a systematic review and meta-analysis was performed.

Methods

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed to review published studies conducted. We searched bibliographic databases from PubMed, Scopus, Google Scholar, and Cochrane Library for studies on the prevalence and antimicrobial susceptibility testing on C. difficile. The weighted pooled prevalence and resistance for each antimicrobial agent was calculated using a random-effects model. A funnel plot and Egger’s regression test were used to see publication bias.

Results

A total of 15 studies were included. Ten articles for prevalence study and 5 additional studies for antimicrobial susceptibility testing of C. difficile were included. A total of 1967/7852 (25%) C. difficile were isolated from 10 included studies for prevalence study. The overall weighted pooled proportion (WPP) of C. difficile was 30% (95% CI: 10.0–49.0; p<0.001). The analysis showed substantial heterogeneity among studies (Cochran’s test = 7038.73, I2 = 99.87%; p<0.001). The weighed pooled antimicrobial resistance (WPR) were: vancomycin 3%(95% CI: 1.0–4.0, p<0.001); metronidazole 5%(95% CI: 3.0–7.0, p<0.001); clindamycin 61%(95% CI: 52.0–69.0, p<0.001); moxifloxacin 42%(95% CI: 29–54, p<0.001); tetracycline 35%(95% CI: 22–49, p<0.001); erythromycin 61%(95% CI: 48–75, p<0.001) and ciprofloxacin 64%(95% CI: 48–80; p< 0.001) using the random effect model.

Conclusions

A higher weighted pooled prevalence of C. difficile was observed. It needs a great deal of attention to decrease the prevailing prevalence. The resistance of C. difficile to metronidazole and vancomycin was low compared to other drugs used to treat C. difficile infection. Periodic antimicrobial resistance monitoring is vital for appropriate therapy of C. difficile infection.
Characteristics of the gut microbiome in women with gestational diabetes mellitus: A systematic review
Authors: Rold Louise Søndergaard , Bundgaard-Nielsen Caspar , Niemann Holm-Jacobsen Julie , Glud Ovesen Per , Leutscher Peter , Hagstrøm Søren , Sørensen Suzette
Published: January 2022

Background

The incidence of women developing gestational diabetes mellitus (GDM) is increasing, which is associated with an increased risk of type 2 diabetes mellitus (T2DM) for both mother and child. Gut microbiota dysbiosis may contribute to the pathogenesis of both GDM and the accompanying risk of T2DM. Thus, a better understanding of the microbial communities associated with GDM could offer a potential target for intervention and treatment in the future. Therefore, we performed a systematic review to investigate if the GDM women have a distinct gut microbiota composition compared to non-GDM women.

Methods

We identified 21 studies in a systematic literature search of Embase and PubMed up to February 24, 2021. Data on demographics, methodology and identified microbial metrics were extracted. The quality of each study was assessed according to the Newcastle-Ottawa Scale.

Results

Sixteen of the studies did find a GDM-associated gut microbiota, although no consistency could be seen. Only Collinsella and Blautia showed a tendency to be increased in GDM women, whereas the remaining genera were significantly different in opposing directions.

Conclusion

Although most of the studies found an association between GDM and gut microbiota dysbiosis, no overall GDM-specific gut microbiota could be identified. All studies in the second trimester found a difference between GDM and non-GDM women, indicating that dysbiosis is present at the time of diagnosis. Nevertheless, it is still unclear when the dysbiosis develops, as no consensus could be seen between the studies investigating the gut microbiota in the first trimester of pregnancy. However, studies varied widely concerning methodology and study design, which might explain the highly heterogeneous gut microbiota compositions between studies. Therefore, future studies need to include multiple time points and consider possible confounding factors such as ethnicity, pre-pregnancy body mass index, and GDM treatment.
Perinatal asphyxia and associated factors among neonates admitted to a specialized public hospital in South Central Ethiopia: A retrospective cross-sectional study
Authors: Mamo Seifu Awgchew , Teshome Girum Sebsibie , Tesfaye Tewodros , Goshu Abel Tibebu
Published: January 2022

Introduction

Perinatal asphyxia continues to be a significant clinical concern around the world as the consequences can be devastating. World Health Organization data indicates perinatal asphyxia is encountered amongst 6–10 newborns per 1000 live full-term birth, and the figures are higher for low and middle-income countries. Nevertheless, studies on the prevalence of asphyxia and the extent of the problem in poorly resourced southern Ethiopian regions are limited. This study aimed to determine the magnitude of perinatal asphyxia and its associated factors.

Methods

A retrospective cross-sectional study design was used from March to April 2020. Data was collected from charts of neonates who were admitted to NICU from January 2016 to December 31, 2019.

Result

The review of 311 neonates’ medical records revealed that 41.2% of the neonates experienced perinatal asphyxia. Preeclampsia during pregnancy (AOR = 6.2, 95%CI:3.1–12.3), antepartum hemorrhage (AOR = 4.5, 95%CI:2.3–8.6), gestational diabetes mellitus (AOR = 4.2, 95%CI:1.9–9.2), premature rupture of membrane (AOR = 2.5, 95%CI:1.33–4.7) fetal distress (AOR = 3,95%CI:1.3–7.0) and meconium-stained amniotic fluid (AOR = 7.7, 95%CI: 3.1–19.3) were the associated factors.

Conclusion

Substantial percentages of neonates encounter perinatal asphyxia, causing significant morbidity and mortality. Focus on early identification and timely treatment of perinatal asphyxia in hospitals should, therefore, be given priority.
Discriminación laboral por razón de sexo, la licencia parental del hombre y de las parejas no tradicionales: un análisis comparado de los ordenamientos español y puertorriqueño
Authors: Bartolomei Rodriguez Felix J.
Published: January 2022

El objetivo principal de esta investigación es analizar el derecho laboral puertorriqueño en el área de discriminación en el empleo, con el propósito de comprobar el principio de igualdad de protección de las leyes y no discriminación. Se examinará particularmente la otorgación de licencias o permisos parentales (maternidad o paternidad) para los padres y las parejas no tradicionales. Esta investigación hace un análisis comparativo del derecho español prestando mayor énfasis al tema de la conciliación familiar y los permisos de suspensión de trabajo o licencia parental por nacimiento, adopción o acogimiento.
Permissivess, guiltiness, anxiety
Authors: Gonçalves Erick , Ribeiro Turato Egberto
Published: January 2022

Introduction: Studies on procrastination are increasing, studies are aimed at university students, as it is the population that most procrastinates their daily activities, especially academic ones. Most studies fail to explain existing conflicts on the subject, suggesting that there are futures with a qualitative focus, where the researcher is closer to the phenomenon, with no research on the topic with OT students.

Objective: To explore and research explanations reported by occupational therapy students at a private university in southeastern Brazil about the behavior of procrastinating schoolwork, considering themselves self-reported as "procrastinators"

Methods: Clinical-qualitative design; data collected through in-depth semi-structured findings with open questions; a thematic analysis generated categories discussed in the light of the psychodynamic framework

Results: Seven OT students were interviewed and, according to the results of the analysis: procrastination linked to anxiety as productivity, but without the executive drive, imprisoning the individual in a vicious cycle of procrastination; defense mechanisms linked to self-preservation so as not to assume responsibility for tasks and other adversities of adult and university life; ineffective methods are tried by students to try to avoid procrastination, but without resolving the emotional and psychodynamic conflicts related to the activity.

Conclusions: Students' procrastination ambivalently affects their daily lives, both positively and negatively, although everyone reported the phenomenon as negative. These studies can contribute to thinking about the clinic in the context of health and education. Therefore, we suggest studies that explore meanings brought by students and even other categories for comparative purposes.
Anniversary of Edith Hinkley Quimby
Authors: Lushchikova A. P. , Chemshit A. I.
Published: January 2022

At the beginning of the 20th century, the whole world was searching for radioactive substances application, in particular radium. Radium can be used to treat oncology, but no one knew the verge of overdosing and underdosing. The founder of radiobiology can be considered Lewis Gray, who introduced unit for absorbed dose of radiation [1]. It was Edith Quimby who started looking for that therapeutically effective absorbed dose. It’s to calculate the minimum effective dose of activity for each patient. She has written 75 articles, published books that have become used concepts in biophysics, and handbooks of modern editions of radiologists. She became the first woman and the first physicist to become president of the American Radium Society, an organization dedicated to the study and treatment of cancer. At one time, Arthur Compton spoke about the need to introduce and apply physics in medicine, and Quimby, in her acceptance speech, outlined the need for an organization of medical physicists, and in 1958, owing to her, the American Society of Medical Physicists was created. Edith Quimby was and remains an iconic figure in the history of the development of medical physics.
INFLUENCE OF RIGIDITY OF ELASTIC ELEMENTS OF COUPLING COUPLINGS ON TORSIONAL VIBRATION OF SHUNTING LOCOMOTIVES DRIVES
Authors: Evdokimov A. P.
Published: January 2022

The results of calculations of torsional vibrations of elements of power drives of shunting locomotives with different torsional rigidity of rubbercord shells of elastic coupling couplings are presented. Based on the results obtained, the choice of rubbercord shells is justified depending on their torsional rigidity. The basis for the choice of shells is the obtained results of calculations of the resonant amplitudes of torsional vibrations by the method of continued fractions.
MIXING PROCESSES AND EQUIPMENT. CONSTRUCTION MIXTURES AND MIXTURES FOR MANUFACTURING CONSTRUCTION MATERIALS. LECTURE 9
Authors: Nizhegorodov A. I.
Published: January 2022

The article presents materials of Lecture 9 Theory of carrying and lifting, construction and road vehicles and equipment, which describes mixing machines, concrete mixtures, their dosage, quality and homogeneity. The process of concrete mixing and energy aspects of its production are described. The data on mixers used for producing mortars and clay suspensions are presented. The design of a special mixer for producing polystyrene-silicate mineralized granules and the production technology for hollow silicate spheres based on the working process of a special mixer are described.
COMBINED EXTRUSION OF GLASSES WITH A CONICAL BOTTOM. KINEMATIC AND STRESS STATES OF THE PLASTIC REGION LOCATED UNDER THE CONICAL SURFACE OF THE PUNCH
Authors: Vorontsov A. L. , Lebedeva D. A.
Published: January 2022

For extrusion of glasses with a conical bottom using the method of plastic flow by A. L. Vorontsov, the kinematic and stress states of the extruded metal in the area of the plastic deformation center located under the conical surface of the punch were determined. The resulting formulas will be used to determine the stress state in the region of the hearth located under the central flat part of the punch-son՚s working end. In the future, the results of this mechanical and mathematical analysis will also make it possible to investigate the question of the presence of the taper of the punch, which is optimal in terms of strength.
TECHNOLOGICAL SUPPORT OF CONTACT RIGIDITY OF MACHINE PARTS
Authors: Bezyazychnyj V. F. , Dmitrieva M. N.
Published: January 2022

The theoretical provisions on establishing the relationship between the geometric characteristics of the surfaces of contacting parts, as well as the physical and mechanical characteristics of the material of these surfaces on their contact stiffness, including the contact stiffness of the surfaces of parts of high-load gas turbine engine components, are presented. The analysis of dependencies on the relationship of contact stiffness and pliability of surfaces with the technological conditions of their processing by various types of cutting process (turning, milling, grinding) is given.
METHOD OF DOMAIN ONTOLOGY AUTOMATED REPLENISHMENT FOR THE SUPPORT OF NEW TECHNICAL SOLUTIONS SYNTHESIS. PART I
Authors: Vasiliev S. S. , Korobkin D. M. , Fomenkov S. A.
Published: January 2022

To solve the problem of information support for the synthesis of new technical solutions, a method of extracting structured data from an array of Russian-language patents is presented. The key features of the invention, such as the structural elements of the technical object and the relationships between them, are considered as information support. The data source addresses the main claim of the invention in the device patent. The unit of extraction is the semantic structure Subject-Action-Object (SAO), which semantically describes the constructive elements. The extraction method is based on shallow parsing and claim segmentation, taking into account the specifics of writing patent texts. Often the excessive length of the claim sentence and the specificity of the patent language make it difficult to efficiently use off-the-shelf tools for data extracting. All processing steps include: segmentation of the claim sentences; extraction of primary SAO structures; construction of the graph of the construct elements f the invention; integration of the data into the domain ontology. This article deals with the first two stages. Segmentation is carried out according to a number of heuristic rules, and several natural language processing tools are used to reduce analysis errors. The primary SAO elements are extracted considering the valences of the predefined semantic group of verbs, as well as information about the type of processed segment. The result of the work is the organization of the domain ontology, which can be used to find alternative designs for nodes in a technical object. In the second part of the article, an algorithm for constructing a graph of structural elements of a separate technical object, an assessment of the effectiveness of the system, as well as ontology organization and the result are considered.
Merger and Acquisition Integration Model: A Practical Approach
Authors: Johan Suwinto
Published: January 2022

This research aims to guide the merger and acquisition process for business practitioners in Asia. The research uses qualitative, descriptive analysis, and inductive approaches. This research is based on the samples of 20 transactions that have been performed in the last 25 years. The transactions involve companies from Indonesia, Malaysia, United States, United Kingdom, Japan, and Canada. The study proposes a merger and acquisition model with seven steps: determining the strategy, searching for the target, reviewing the target, confirmation and negotiation, transaction, and integrating into a business. The result of this study contributes to a new model of merger acquisition integration. The model will show the integration process in the financial services industry in South East Asia. The results support previous studies. The acquisition and integration model will assist the company's management in South East Asian countries to manage the merger integration process, especially in the financial industry. This research provides an integration model according to transactions in Asia in the financial service industry.
Studi tentang Pengaruh Kepuasan Pelanggan terhadap Ekuitas Merk dan Word of Mouth pada Bengkel AHASS Semarang Barat
Authors: Gunawan Eric , Sukresna I Made , Sugiono Sugiono
Published: January 2022

Penelitian ini dilakukan dengan tujuan untuk melihat pengaruh Customer Satisfaction terhadap Brand Equity dan Word of Mouth pada bengkel AHASS. Variabel yang ditambahkan adalah Service Quality dan Perceived Price sebagai Moderating Variabel yang berpengaruh terhadap Customer Satisfaction.Sampel penelitian ini adalah para pelanggan Bengkel AHASS kota Semarang bagian Barat. Analisis data  Structural Equation Model (SEM) menggunakan program software AMOSS dan SPSS. Hasil analisis menunjukkan bahwa Customer Satisfaction berpengaruh positif terhadap Brand Equity dan Word of Mouth. Service Quality berpengaruh positif terhadap Customer Satisfaction yang dimoderasi oleh Perceived Price sebagai Quasi Moderator.
Konsekuensi Green Trust Terhadap Green Perceived Value, Green Perceived Risk dan Green Repurchase Intention
Authors: Lisnaningrum Destya , Sabihaini Sabihaini , Ghofar Abdul
Published: January 2022

This study determine the effect of green perceived value and green perceived risk on green repurchase intention mediated by green trust in customers of The Body Shop products in the Special Region of Yogykarta. The independent variables are green perceived value and green perceived risk. The dependent variable is a green repurchase intention. Green trust is a mediating variable. The population in this study are customers of The Body Shop products. Sample collection is done by area sampling techniques by grouping DIY into 5 groups, namely Bantul, Gunungkidul, Kota Yogyakarta, Kulon Progo, Sleman and the purposive sampling with the criteria of having made at least 2 purchases of The Body Shop products number of 150 respondents. The data analysis method used in this study is structural equation modeling (SEM). The results of this study are If consumers feel the benefits of a product towards the environment is high, it will increase trust and repurchase in the product. If consumers have a negative perception of a product that is high it will reduce trust and reduce interest in repurchasing the product. Consumer trust in products can mediate consumer ratings of the benefits received, negative perceptions and repurchase in the product.