bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Bovine Trypanosomiasis and Associated Risk Factors in Benatsemay District, Southern Ethiopia
Authors: Fesseha Haben , Eshetu Eyob , Mathewos Mesfin , Tilante Tishine
Published: May 2022

Trypanosomosis is an endemic livestock disease in Ethiopia that hinders livestock production and productivity, especially in fertile agricultural western and southwestern areas. A cross-sectional questionnaire-based and parasitological studies were conducted from October 2020 to July 2021 in the Benatsemay district, southern Ethiopia to assess the knowledge of livestock owners about trypanosomosis, its prevalence, and host-related risk factors associated with bovine trypanosomosis in the area. According to the questionnaire survey, trypanosomosis was the main bottleneck to cattle in two of the selected study Sites in the Benatsemay district. The parasitological survey revealed that 11.46% (44/384) of the cattle were infected with trypanosomosis. Moreover, Trypanosoma congolense (9.11%) is the leading trypanosome species in the area, followed by T. vivax (31.8%). The adult age group (16.15%), poor-conditioned cattle (22.22%), and black-skinned cattle (34.24%) were significantly associated ( P < .05) with trypanosomosis infection in the study area. Furthermore, the mean packed cell volume (PCV) of parasitaemic cattle (22.75%) was significantly ( P < .05) lower than that of aparasitaemic cattle (29.23%). Therefore, the present study revealed that the prevalence of bovine trypanosomosis in the study area and participatory vector control and the rational use of trypanocidal drugs should be implemented to control trypanosomosis in the area.
Implementing patient navigator programmes within a hospital setting in Toronto, Canada: A qualitative interview study
Authors: Kokorelias Kristina M , Gould Sarah , Das Gupta Tracey , Ziegler Naomi , Cass Dan , Hitzig Sander L
Published: May 2022

Objectives:

This study sought to identify the organisation and system level barriers and facilitators influencing the implementation of patient navigator programmes in one acute care hospital system in Toronto, Canada.

Methods:

A qualitative descriptive approach informed by the Consolidated Framework for Implementation Research. Data were collected using in-depth interviews and analysed thematically.

Results:

Thirty-eight individuals participated in interviews (17 community, 21 acute care hospital), including 24 frontline clinicians and 14 programme directors, health care leaders and managers. Implementation of patient navigator programmes was dependent on: (1) a clear consensus on the unique need for patient navigators; (2) champions to promote patient navigation; (3) programme ownership and accountability; (4) external system and organisational landscape and (5) implementation climate. Appropriate mechanisms of communication were found to have impacted each factor as a barrier or facilitator to programme implementation.

Conclusion:

Strategies for implementing patient navigator programmes into hospital clinical practice should include incorporating evidence to support the programme, considering mechanisms to enable collaborative communication, and the integration of frameworks to facilitate programme integration into the current practices within the organisation.
A 6-year retrospective review of psychiatric emergency service utilization by school-age children
Authors: Rana Gagandeep S , Nordsletten Ashley , Sivananthan Mauran , Hong Victor
Published: May 2022

To explore utilization patterns and associated clinical factors of school-age children who present to a psychiatric emergency department. This was a 6-year retrospective chart review study of children 5–12 years of age who presented to a psychiatric emergency service from July 2012 to June 2018 ( n = 1654 patients). Demographic variables, clinical diagnoses, lifetime adverse events (physical abuse, sexual abuse, and bullying), and history of self-harm were documented for each visit. We performed a chi square analysis to identify association between demographic and clinical features with key outcomes. Increased service utilization as defined by inpatient psychiatric admission, recurrent visits, or increased length of stay were found in patients who were adopted, presented with suicidal ideation or self-harm behaviors, had a history of abuse, and had a diagnosis of depression or autism. Trends over the course of the study indicated a significantly increased percentage of patients presenting with suicidal ideation, bullying, and self-harm behaviors. The data add to the limited literature regarding school-age children with a psychiatric emergency. Increased emergency service utilization for certain subgroups of children and trends over the course of the study underscore the need for enhanced treatment options for individuals with certain demographic or clinical features, and increased outpatient, intermediate, and inpatient treatment options, as well as preventative care.
Experimental investigation on steel-concrete composite beams with expansion joints in concrete slab
Authors: Lin Weiwei , Taniguchi Nozomu , Kubo Takeaki
Published: May 2022

This study examines experimentally the mechanical performance of composite steel and concrete beams with expansion joints in the concrete slab. Four composite beams with expansion joints in the concrete slab were tested, and various aspects of such beams including the effects of expansion joint locations ([Formula: see text], [Formula: see text], and [Formula: see text], where [Formula: see text]), expansion joint sizes (through and half-through of the concrete depth), and loading conditions (positive bending moment and negative bending) etc., were investigated. Load versus vertical deflection responses at key sections, and the strain development and distribution on the steel beam were measured. To explore the behavior of shear connectors on or near the expansion joint sections, the normal strain on shear connectors was measured. The bending strain and axial strain of shear connectors on joint sections were also discussed in detail. The theoretical methods for predicting the rigidities and ultimate load-carrying capacities of the composite beams were examined, and it was found that the current AASHTO-LRFD criterion without considering expansion joints in a concrete slab can still provide conservative estimations of ultimate loads of such beams under a negative moment. For composite beams under a positive bending moment, however, they are not applicable, due to the different failure modes. The test results from this research provide new information for improving the design, construction, management, maintenance, and structural health assessment of such beams that can be used in bridges and buildings, etc.
Three-dimensional nonlinear aerostatic stability analysis of long-span suspension bridges under skew wind
Authors: Zhang Xinjun , Sun Leilei , Ying Fubin
Published: May 2022

Based on the aerostatic force model under skew wind, considering the nonlinear and three-dimensional effects of aerostatic forces and also structural geometric nonlinearity, a method of three-dimensional nonlinear aerostatic stability analysis under skew wind is presented, and the corresponding computational procedure (SNAA-SW) is developed. By taking a suspension bridge- the Runyang suspension bridge over the Yangtze River as example, 3D nonlinear aerostatic stability analysis of the bridge under skew wind is conducted, and the skew wind effect on the aerostatic stability of long-span suspension bridges is ascertained. The results show that the skew wind effect does not change the aerostatic instability mode of suspension bridges, which shows a spatial bending-torsion coupled instability mode as the same as normal wind case. The skew wind has positive and negative effects on the aerostatic stability of suspension bridge under different wind attack angles, and the evolutions of critical wind speed of aerostatic instability with wind yaw angle are completely different from the cosine rule as proposed by the skew wind decomposition method, for most cases, the lowest critical wind speed of aerostatic instability occurs under skew wind. With the increase of wind yaw angle, the skew wind effect on the critical wind speed of aerostatic instability becomes more prominent, and the influence is between −10.7% and 8.1%. Therefore, the skew wind effect needs to be accurately considered in the aerostatic stability analysis of long-span suspension bridges in particular at large wind yaw angles.
Open-source electronic health record systems: A systematic review of most recent advances
Authors: Shaikh Mohsin , Vayani Arshad HM , Akram Sabina , Qamar Nafees
Published: May 2022

Open-source Electronic Health Records (OS-EHRs) are of pivotal importance in the management, operations, and administration of any healthcare organization. With the advancement of health informatics, researchers and healthcare practitioners have proposed various frameworks to assess the maturation of Open-source EHRs. The significance of OS-EHRs stems from the fact that vendor-based EHR implementations are becoming financially burdensome, with some vendors raking in more than $1 billion with one contract. Contrarily, the adoption of OS-EHRs suffers from a lack of systematic evaluation from the standpoint of a standard reference model. To this end, the Healthcare Information and Management Systems Society (HIMSS) has presented a strategic road map called EMR Adoption and Maturity (EMRAM). The HIMSS-EMRAM model proposes a stage-wise model approach that is globally recognized and can be essentially applied as a benchmark evaluation criteria for open-source EHRs. This paper offers an applied descriptive methodology over the frequently studied open-source EHRs currently operational worldwide or has the potential of adoption in healthcare settings. Besides, we also present profiling (User Support, Developer’ Support, Customization Support, Technical details, and Diagnostic help) of studied OS-EHRs from developer’s and user’s perspectives using updated standard metrics. We carried out multi-aspect objective analysis of studied systems covering EHR functions, software based features and implementation. This review portrays systematic aspects of electronic medical record standards for open-source software implementations. As we observed in the literature, prevalent research and working prototypes lack systematic review of the HIMSS-EMRAM model and do not present evolving software features. Therefore, after the application of our assessment measures, the results obtained indicate that OS-EHRs are yet to acquire standard compliance and implementation. The findings in this paper can be beneficial in the planning and implementation of OS-EHRs projects in the future.
Deep learning-based prediction of heart failure rehospitalization during 6, 12, 24-month follow-ups in patients with acute myocardial infarction
Authors: Bat-Erdene Bat-Ireedui , Zheng Huilin , Son Sang Hyeok , Lee Jong Yun
Published: May 2022

Heart failure is a clinical syndrome that occurs when the heart is too weak or stiff and cannot pump enough blood that our body needs. It is one of the most expensive diseases due to frequent hospitalizations and emergency room visits. Reducing unnecessary rehospitalizations is also an important and challenging task that has the potential of saving healthcare costs, enabling discharge planning, and identifying patients at high risk. Therefore, this paper proposes a deep learning-based prediction model of heart failure rehospitalization during 6, 12, 24-month follow-ups after hospital discharge in patients with acute myocardial infarction (AMI). We used the Korea Acute Myocardial Infarction-National Institutes of Health (KAMIR-NIH) registry which included 13,104 patient records and 551 features. The proposed deep learning-based rehospitalization prediction model outperformed traditional machine learning algorithms such as logistic regression, support vector machine, AdaBoost, gradient boosting machine, and random forest. The performance of the proposed model was accuracy, the area under the curve, precision, recall, specificity, and F1 score of 99.37%, 99.90%, 96.86%, 98.61%, 99.49%, and 97.73%, respectively. This study showed the potential of a deep learning-based model for cardiology, which can be used for decision-making and medical diagnosis tool of heart failure rehospitalization in patients with AMI.
Critical historiography and the problem of judgment
Authors: Zerilli Linda M. G.
Published: May 2022

Max Tomba aims to reconstruct how historical actors reconstructed the past to open the future in ways that diverged from the trajectory of the dominant modernity. Insurgent Universality would break open the dead logic of the juridical, political, and economic trajectory of modernity that limits what is given and constrains what is possible. This essay reflects on the practice and the role of the historian. Beyond merely adopting insurgents’ perspectives, the historian must engage in a practice of critical and reflective judgment. The essay draws on Michel-Rolph Trouillot on the silencing of the past, Reinhard Koselleck on the priority of the future, and Marisa Fuentes on the limits of the archives for voicing marginalized points of view. It concludes by calling for judgment and imagination where the archives run dry.
Fifty years of shape grammars: A systematic mapping of its application in engineering and architecture
Authors: Haakonsen Sverre Magnus , Rønnquist Anders , Labonnote Nathalie
Published: May 2022

Shape grammars allow a designer to explore a diverse and broad design space. Especially among architects and engineers, the opportunity to evaluate numerous alternatives in the conceptual phase facilitates creativity. Since the introduction of shape grammars 50 years ago, significant research and development have been performed: new applications, combinations with optimisation and integration in digital environments, among others. Consequently, there is a need to map the existing literature to encourage further progress in the field and a lower threshold for those interested in learning more about shape grammars. This study, therefore, presents a systematic mapping of shape grammars in architecture and engineering. Mapping is performed by identifying a query of relevant keywords used in five databases, with the results forming the basis of the mapping. Each of the included articles is then screened to filter out those that do not fit the content criteria. The remaining publications are then evaluated and organised based on the attributes’ application, research type, implementation, engineering and optimisation. The outcome is organised in explanatory illustrations and tables. The final discussion highlights the extensive work performed with shape grammars in the generation of two-dimensional floor plans, an increase in digital development in recent years and the need for further research. The findings indicate a gap between the state of the art and the necessary level of applicability for shape grammars to be an attractive design tool, especially for non-experts.
Nudging as a Support for Behavioral Change in Lifestyle Medicine
Authors: Matthews Simon
Published: May 2022

The practice of lifestyle medicine and its emphasis on behavioral change continues to grow around the world. Yet much of the burden of disease weighing on healthcare systems from chronic, modifiable conditions remains stubbornly present. From a behavior change perspective, efforts to date have primarily focused on public health messaging and public health campaigns (global approaches) to interventions such as health coaching (individual approaches). There exists an opportunity to consider contextual elements which support behavioral change. The practice of “nudging” behavior in primary care and allied health settings is proposed as a means of responding to these contextual opportunities. Nudging does not assure change; however, it can invite curiosity about change and small behavioral efforts in the direction of a desired change. Furthermore, its nature conserves autonomy and patient choice while inviting a health-creating behavior. As such, when considered and applied in the context of public health and individual treatment options, it creates a consistent milieu in which behavior change is facilitated.
Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection
Authors: Novotny Tomas , Staffa Robert , Tomandl Josef , Krivka Tomas , Kruzliak Peter , Tomandlova Marie , Slaby Ondrej , Sponiar Jan , Caprnda Martin , Gaspar Ludovit , Rodrigo Luis , Mozos Ioana , Kubicek Lubos , Biros Ernest , Vlachovsky Robert , Radova Lenka , Konieczna Anna
Published: May 2022

Objective

The purpose of our study was to describe perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery, to compare the kinetics in the open abdominal aortic aneurysm (AAA) repair and aortobifemoral bypass for aortoiliac occlusive disease (AIOD), and to evaluate the ability of PCT to detect intestinal ischaemia.

Methods

A prospective non-randomized observational cohort study in 80 patients (62 men and 18 women) undergoing elective aortic surgery was performed. Serum PCT was measured at baseline and defined intraoperative and postoperative timepoints up to postoperative day 7. MRI contrast-enhanced imaging was used to detect intestinal ischaemia.

Results

The comparison of the AAA and AIOD cohort did not show any significant difference in PCT levels. Patients with intestinal ischaemia had higher serum PCT at multiple timepoints postoperatively. The most accurate timepoints for early diagnosis were postoperative day 3, followed by 24 h after declamping of the vascular reconstruction, and postoperative day 7. The sensitivity and negative predictive values were 100% in all mentioned timepoints. However, event at the best timepoint the specificity was 89% and the positive predictive value 43%.

Conclusions

Procalcitonin levels in the postoperative period at proper timepoints might help to detect postoperative intestinal ischaemia. The limitation of this marker is its low specificity for intestinal ischaemia and low positive predictive value. The highest value of this marker is that it can rule out this complication because normal PCT levels mean that intestinal ischaemia is very unlikely.
Prevalence and determinants of the involvement of married men in family planning services in Ethiopia: A systematic review and meta-analysis
Authors: Kassa Bekalu Getnet , Tenaw Lebeza Alemu , Ayele Alemu Degu , Tiruneh Gebrehiwot Ayalew
Published: May 2022

Background:

Male involvement in family planning includes not only using contraceptives but also encouraging and supporting their partners’ contraception needs and choices, encouraging peers to use family planning, and influencing policy to make male-related programs more conducive. In Ethiopia, the prevalence and associated factors of male involvement in family planning were highly inconsistent across studies. As a result, the goal of this study was to use a systematic review and meta-analysis to estimate the pooled prevalence of male involvement in family planning and its associated factors in Ethiopia.

Methods:

Electronic literature search using PubMed, Google Scholar, EMBASE, HINAR, Scopus, and Web of Sciences were performed without time restriction to identify the primary studies. Data were extracted using a pretested standardized data extraction format and analyzed using STATA 14 statistical software. A random-effect model was used to estimate the pooled prevalence of male involvement.

Results:

A total of 17 studies were included to give the pooled prevalence of male involvement in family planning in Ethiopia, which was 39.66% (95% confidence interval = 29.86, 49.45). Educational status (adjusted odds ratio = 1.99, 95% confidence interval = 1.26, 3.14), discussion of family planning with wife (adjusted odds ratio = 4.15, 95% confidence interval = 2.21, 7.80), knowledge (adjusted odds ratio = 1.83, 95% confidence interval = 1.26, 2.64), positive attitude about family planning (adjusted odds ratio = 2.57, 95% confidence interval = 1.70, 3.90), and approval of contraceptive use (adjusted odds ratio = 2.57, 95% confidence interval = 1.70, 3.90) were found to be significantly associated with involvement of men in family planning service.

Conclusion:

The overall prevalence of male involvement in family planning in Ethiopia was significantly low. Male involvement in family planning should be made available, accessible, and advocated for by government and non-governmental organizations, service providers, program planners, and stakeholders. In addition, to increase the role of men in the use of family planning services, a conducive environment for education, behavioral change, and open discussion about reproductive health issues is required.
The effect of repeated remote ischemic postconditioning after an ischemic stroke (REPOST): A randomized controlled trial
Authors: Landman Thijs RJ , Schoon Yvonne , Warlé Michiel C , Meijer Frederick JA , Leeuw Frank-Erik De , Thijssen Dick HJ
Published: May 2022

Background and Aims:

A potential strategy to treat ischemic stroke may be the application of repeated remote ischemic postconditioning (rIPostC). This consists of several cycles of brief periods of limb ischemia followed by reperfusion, which can be applied by inflating a simple blood pressure cuff and subsequently could result in neuroprotection after stroke.

Methods:

Adult patients admitted with an ischemic stroke in the past 24 h were randomized 1:1 to repeated rIPostC or sham-conditioning. Repeated rIPostC was performed by inflating a blood pressure cuff around the upper arm (4 × 5 min at 200 mm Hg), which was repeated twice daily during hospitalization with a maximum of 4 days. Primary outcome was infarct size after 4 days or at discharge. Secondary outcomes included the modified Rankin Scale (mRS)-score after 12 weeks and the National Institutes of Health Stroke Scale (NIHSS) at discharge.

Results:

The trial was preliminarily stopped after we included 88 of the scheduled 180 patients (average age: 70 years, 68% male) into rIPostC (n = 40) and sham-conditioning (n = 48). Median infarct volume was 2.19 mL in rIPostC group and 5.90 mL in sham-conditioning, which was not significantly different between the two groups (median difference: 3.71; 95% CI: −0.56 to 6.09; p = 0.31). We found no significant shift in the mRS score distribution between groups. The adjusted common odds ratio was 2.09 (95% CI: 0.88–5.00). We found no significant difference in the NIHSS score between groups (median difference: 1.00; 95% CI: −0.99 to 1.40; p = 0.51).

Conclusion:

This study found no significant improvement in infarct size or clinical outcome in patients with an acute ischemic stroke who were treated with repeated remote ischemic postconditioning. However, due to a lower-than-expected inclusion rate, no definitive conclusions about the effectiveness of rIPostC can be drawn
CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma
Authors: Chen Zhiping , Gong Qiaoying , Li Daojing , Zhou Juying
Published: May 2022

Background

Nasopharyngeal carcinoma (NPC) represents a head and neck cancer caused by cancerization of nasal epithelial cells. HOXA10 has been identified to promote proliferation and invasion of NPC cells, but its regulatory mechanism has not been well discussed. Published research work has also pointed out that circular RNAs (circRNAs) could regulate mRNAs to affect NPC tumorigenesis and development.

Aim

To explore the roles of HOXA10 and its specific regulatory mechanism regarding circRNAs in NPC.

Methods

Reverse transcription polymerase chain reaction and western blot were applied to test gene expression. Functional assays were used to evaluate changes in NPC cell phenotypes. Mechanism assays were done to verify RNA-RNA or RNA-protein interaction.

Results

HOXA10 was highly expressed in NPC tissues and cell lines. Moreover, HOXA10 knockdown could restrict NPC cell proliferation, invasion, migration, and epithelial–mesenchymal transition. CircKIAA0368 was upregulated in NPC cells and could elevate HOXA10 expression by sponging miR-6838-5p. Furthermore, circKIAA0368 was unveiled to competitively bind to p300/CREB-binding protein-associated factor (PCAF) to repress acetylation and degradation of HOXA10 protein.

Conclusion

CircKIAA0368 upregulates HOXA10 expression via miR-6838-5p and PCAF, consequently promoting NPCcell and tumor growth.
The entitativity underlying meetings: Meetings as key in the lifecycle of effective workgroups
Authors: Blanchard Anita L. , Allen Joseph A.
Published: May 2022

As more employees work in different locations, meetings become the primary opportunity for workgroup interactions. We explore how workgroup entitativity develops within successful meetings and grounds positive employee and group outcomes between meetings. Social identity theory and self-categorization processes explain how entitativity develops during meetings and activates workgroup identification between meetings. Further, construal level theory, which establishes that physical and psychological distance are positively related, affects entitativity and social identity for dispersed and hybrid workgroups. We propose that entitativity develops in meetings through interactions, co-presence, leader behavior, and meeting size. Between meetings, the frequency of self-categorization into a workgroup identity maintains and even increases workgroup entitativity. Further, task interdependence, informal interactions, and time between meetings affects frequency of self-categorization and, thus, employees’ workgroup entitativity between meetings. We conclude that meetings serve as the primary formal occasion in which workgroup entitativity can be maintained or repaired for optimal workgroup performance.
Enriching the learner’s model through the semantic analysis of learning traces
Authors: Ait-Adda Samia , Bousbia Nabila , Balla Amar
Published: May 2022

Our aim in this paper is to improve the efficiency of a learning process by using learners’ traces to detect particular needs. The analysis of the semantic path of a learner or group of learners during the learning process can allow detecting those students who are in needs of help as well as identify the insufficiently mastered concepts. We examine the possibility of using a student’s browsing path during a learning session, based on his navigation traces, to update the learner model. We assume that the domain concepts examined outside the learning platform but that are related to the course concepts are problematic to the learner. Knowing about these concepts may allow the course’s author to adapt the course to the learner’s needs regarding these concepts, as well as allow the tutor to help and assist the learner on these problematic concepts. We rely on Web data mining methods to filter, organize, and analyze the student’s browsing path. More precisely, we use a domain ontology of the course and the similarities that exist between external documents (visited pages) and the domain concepts (the course keywords). This analysis process makes it possible to detect students’ learning difficulties and to adapt the course based on the learner’s model.
Abdominal cutaneous nerve entrapment syndrome: A cross sectional survey of treatment outcomes
Authors: Kanakarajan Saravanakumar , Dharmavaram Sudhindra , Tadros Amir , Pushparaj Hemkumar , Rose Anna
Published: May 2022

Objective

Abdominal Cutaneous Nerve Entrapment Syndrome (ACNES) is a common but under recognised cause of chronic abdominal wall Pain. This survey was carried out to understand the clinical course of the condition following interventions such as nerve blocks and surgical release of entrapped nerve.

Design

Retrospective, Cross-sectional survey.

Setting

Pain Management clinic at University teaching hospital.

Subjects

Adult patients who had interventions either nerve block or surgical release over a 6 year period.

Methods

After written informed consent, participants completed a questionnaire including Brief Pain Inventory (BPI), quality of health measure (EQ-5D-5L), and global impression of change scale as well as open-ended question about the outcomes. Baseline demographics, details of pain condition, interventions received were collected from the health records.

Results

The diagnosis of ACNES was established in 85.2% by ultrasound guided injections. The injection therapy with local anaesthetic and steroid was successful to 75.8% while the surgical release was successful in 90%. The cumulative duration of pain relief varied from 3 weeks to 5 years. A significant difference was noted in BPI ( p = 0.001), EQ-5D-5L ( p = 0.002) and health thermometer ( p = 0.009) post interventions.

Conclusions

Ultrasound guided injections aid the accurate diagnosis of ACNES. Appropriate treatment of ACNES improves both pain control and quality of life.
Tuberculosis and comorbidities: treatment challenges in patients with comorbid diabetes mellitus and depression
Authors: Cáceres Guillermo , Calderon Rodrigo , Ugarte-Gil Cesar
Published: May 2022

Tuberculosis is one of the leading causes of death worldwide, primarily affecting low- and middle income countries and individuals with limited-resources within fractured health care systems. Unfortunately, the COVID-19 pandemic has only served to aggravate the already existing diagnostic gap, decreasing the number of people who get diagnosed and thereby complete successful treatment. In addition to this, comorbidities act as an external component that when added to the TB management equation, renders it even more complex. Among the various comorbidities that interact with TB disease, diabetes mellitus and depression are two of the most prevalent among non-communicable diseases within the TB population and merits a thoughtful consideration when the healthcare system provides care for them. TB patients with diabetes mellitus (TB-DM) or depression both have an increased risk of mortality, relapse and recurrence. Both of these diseases when in presence of TB present a ‘vicious-circle-like’ mechanism, meaning that the effect of each disease can negatively add up, in a synergistic manner, complicating the patient’s health state. Among TB-DM patients, high glucose blood levels can decrease the effectiveness of anti-tuberculosis drugs; however, higher doses of anti-tuberculous drugs could potentially decrease the effects of DM drugs. Among the TB-depression patients, not only do we have the adherence to treatment problems, but depression itself can biologically shift the immunological profile responsible for TB containment, and the other way around, TB itself can alter the hormonal balance of several neurotransmitters responsible for depression. In this paper, we review these and other important aspects such as the pharmacological interactions found in the treatment of TB-DM and TB-depression patients and the implication on TB care and pharmacological considerations.
Catholic-Maya Sacrificial Commitments
Authors: Dapuez Andrés
Published: May 2022

In their annual festival in an eastern village of the Yucatan state, participants verbalized, discussed, and disputed two main understandings of Catholic commitment after a Catholic priest asked his parishioners to reconsider the effects of their ritual offerings. His teachings about compromiso signaled other ritualized practices, which compose the concept: promises and sacrifices. In direct contrast to the priest’s teachings, local ritualists understand that solemn promises and sacrificial exchange work, however, as encompassments of the notion of commitment. On the other hand, the priest’s notion of engagement with the sacred takes its main force from the representation of the work of dying of sacrificial victims. Overcoming an apparently insurmountable pair of opposites, ritual and sacrificial, he defines commitment as vicarious sacrifice, inaugurating for his audience a new representational dimension.
Recurrent sudden cardiac death secondary to anomalous right coronary artery: Insights into prevalence and management
Authors: Durowoju Rasheed O , Weaver Hannah J , Huang Gary S , Abdelmotleb Mohamed , Alhama-Belotto Marta , Kwon Younghoon
Published: May 2022

A 32-year-old woman presented after ventricular fibrillation arrest requiring three defibrillations. The episode coincided with an upper respiratory infection and physical exertion. Eight years prior, she survived another cardiac arrest of unknown cause during childbirth. This time, imaging revealed an anomalous right coronary artery connecting to the left coronary cusp, with a small, slit-like osteal orifice coursing between the aorta and pulmonary artery. Surgical exploration revealed an intramural segment of the right coronary artery, which was surgically unroofed with improvement in cardiac function. An implantable cardioverter-defibrillator was implanted for secondary prevention of sudden cardiac death. Surgery is recommended for malignant anomalous coronary arteries, with a very low risk of recurrence of arrhythmia and sudden cardiac death after surgery. However, with growing evidence for persistent risk of arrhythmia and sudden cardiac death even after surgical correction of the anomalous coronary arteries, more experts choose to take secondary prevention measures as a component of initial management.
The effect of auditory stimulation using delta binaural beat for a better sleep and post-sleep mood: A pilot study
Authors: Dabiri Roya , Monazzam Esmaielpour Mohammad Reza , Salmani Nodoushan Mojahede , khaneshenas Farin , Zakerian Seyed Abolfazl
Published: May 2022

Background

Although previous evidence confirms the effects of sleep deprivation on mental health and wellbeing, due to the interaction effects of sleep and mood on each other, the influence of sleep improvement has received less attention.

Objective

This study aimed to find whether binaural beat technology can enhance sleep quality and thus post-sleep mood.

Methods

Twenty healthy students participated in this pilot study. All subjects were investigated for two weeks (a baseline week and an experimental week). In the first week, there was no intervention, but in the second week, all subjects were exposed to a 90 min binaural beat in the delta frequency range. The individuals’ sleep was monitored for two weeks using a sleep diary form, and a Profile of Mood State questionnaire was employed to assess their mood at the end of the first and second weeks.

Results

Auditory stimulation with delta binaural beat enhanced sleep parameters such as sleep failure, the number of awakenings, real duration of sleep, sleep quality, and feeling following the waking of the individuals. Finally, students’ moods improved by reducing anxiety and anger, but other mood parameters did not indicate a significant difference.

Conclusion

The findings of this study confirmed that auditory stimulation with a delta binaural beat seems to be a low-cost and alternative method for medicine and other treatment methods with side effects.

Application

This study demonstrates the use of technology with a neuroergonomics approach to improve sleep and mood disorders.
Asian Drinking Cultures in New Zealand: A Scoping Review
Authors: Adams Jeffery , Wong Grace , Zhao Ivy Y. , Saravanakumar Padmapriya , Holroyd Eleanor , Neville Stephen
Published: May 2022

Alcohol use causes harm across most populations. However, comparatively little research and policy attention has been paid to drinking cultures among Asian people. A scoping review was undertaken to identify drinking patterns, alcohol-related harm, drinking culture among Asian youth, young adults, and adults living in New Zealand. A search of literature identified 39 relevant outputs. The findings indicated that Asian people enjoy a comparative health advantage when compared with non-Asian population groups through lower rates of alcohol consumption, less risky drinking, and experiencing less harm from drinking. Despite these advantages, the results identified areas where improvements with Asian people’s relationships and experiences with alcohol may be warranted. It is important to develop targeted approaches to Asian drinking that can build on the current whole population-level alcohol initiatives. Further research is warranted to identify specific and additional strategies to address problematic alcohol use in this cohort.
Selection and Socialization Effects of Living On vs. Off Campus
Authors: Lefkowitz Eva S. , Walters Tracy L.
Published: May 2022

College students who live off campus vs. on campus substantially differ, which may be due to socialization or self-selection. We examined longitudinal differences in academics and activities, alcohol use and adjustment, and sexual behaviors between college students who remained on campus vs moved off campus (N = 607). Findings provide more support consistent with selection than with socialization effects. At the start of college, students who eventually moved off campus were less likely to work, drank alcohol more frequently, felt better about their self-image in social relationships, and recently had more kissing and penetrative sex partners than their peers who stayed on campus. When there was support for differences in change over time, it generally indicated that the two groups became more, not less, similar. In support of Developmental Systems Theory (Lerner & Walls, 1999), findings suggest students shape their own environments, and have implications for developing targeted prevention programming.
Risk Factors for Subsidence Following Anterior Lumbar Interbody Fusion
Authors: Zavras Athan G. , Federico Vincent , Nolte Michael T. , Butler Alexander J. , Dandu Navya , Munim Mohammed , Harper Daniel E. , Lopez Gregory D. , DeWald Christopher J. , An Howard S. , Singh Kern , Phillips Frank M. , Colman Matthew W.
Published: May 2022

Study Design

Retrospective cohort

Objective

Anterior lumbar interbody fusion (ALIF) may be complicated by subsidence, which can lead to significant morbidity including pain, disc space collapse, neural compression, segmental kyphosis, instability, and vertebral body fracture. This study sought to identify patient and procedural risk factors for subsidence in patients undergoing ALIF.

Methods

This study analyzed consecutive patients who underwent ALIF at a single institution with a minimum of 2 years follow-up. Patients were grouped as either Non-Subsidence (NS-ALIF) or Cage Subsidence (CS-ALIF) based on the final postoperative radiograph. Demographic variables, operative characteristics, and radiographic outcomes were evaluated to identify significant predictors on univariate and multivariate statistics.

Results

144 patients (170 levels) were included with an average follow-up of 50.70 ± 28.44 months (4.23 years). The incidence of subsidence was 22.94% (39/170 levels). On univariate statistics, the CS-ALIF group was significantly older (P = .020), had higher BMI (P = .048), worse ASA (P = .001), higher prevalence of comorbid osteoporosis (P < .001), and a more anteriorly placed interbody device (P = .005). On multivariate analysis, anterior cage placement remained the only significant predictor (OR: 1.08, 95% CI: 1.03–1.14; P = .003). There was a significantly higher rate of subsequent adjacent segment surgery among the CS-ALIF group (P = .035).

Conclusion

Factors contributing to subsidence in ALIF included older age, higher BMI, severe ASA, and osteoporosis, while anterior cage placement remained the only independent predictor on multivariate analysis. Subsidence was associated with a higher rate of subsequent adjacent segment surgery. Surgical technique should optimize placement of the interbody cage and avoid overstuffing the disc space.
Rapidly Accumulating Pleural Effusion: A Sequela of Chronic Pancreatitis
Authors: Sandhu Michael , Bernshteyn Michelle , Banerjee Sanchari , Kuhn Michael
Published: May 2022

Chronic pancreatitis presents with epigastric abdominal pain, nausea, vomiting, and weight loss. Acute pancreatitis can also present with a pleural effusion which is typically left-sided, mild in nature, and self-limiting. However, recurrent bouts of pancreatitis may lead to a pancreaticopleural fistula (PPF) with a large, rapidly recurring, unilateral pleural effusion. Among patients with PPF, the most common presenting complaint is dyspnea. We present the case of a 53-year-old man with recurrent bouts of pancreatitis in the setting of alcohol who presented with progressively worsening shortness of breath. A high-resolution computed topography scan of the thorax demonstrated a large right-sided pleural effusion. A thoracentesis was performed with pleural fluid studies showing an exudative effusion with amylase significantly elevated at 18 382 U/L. An endoscopic retrograde cholangiopancreatography was performed which showed a pancreatic duct leak in the tail of the pancreas. A pancreatic sphincterotomy was performed, and a stent was placed into the ventral pancreatic duct. The patient’s shortness of breath improved, and he was discharged home with outpatient follow-up. The aim of this report is to present the diagnosis of a rare complication of chronic pancreatitis and discuss the management and options for treatment.
Description and Functional Benefits of Meeting Frequency, Intensity, and Time of Resistance and Cardiovascular Exercises: A Study of Older Adults in a Community-Based, Slow-Stream Rehabilitation, Hospital-to-Home Transition Program
Authors: Maximos Melody , Stratford Paul , Tang Ada , Dal Bello-Haas Vanina
Published: May 2022

This prospective cohort study described cardiovascular and resistance exercises completed by older adults in a community-based, slow-stream rehabilitation, hospital-to-home transition program; compared exercises completed to the American College of Sports Medicine (ACSM) exercise guidelines; and, assessed differences in Late Life Function and Disability Index (LLFDI)-Function Component (FC) between older adults who met and did not meet the ACSM guidelines. Descriptive statistics and Factorial ANCOVA were conducted. For cardiovascular exercise 59.3% of participants met frequency, 73.4% met intensity, and 35.9% met time. For resistance exercise, 67.2% of participants met frequency, 42.2% met intensity, and 76.6% number of repetitions. Participants who met both frequency and time for cardiovascular exercise had higher LLFDI-FC scores, as did those who met intensity and/or number of repetitions for resistance exercise. The findings provide support that older adults engaged in a slow-stream rehabilitation program can meet the ACSM exercise guidelines for community-dwelling older adults, and that meeting the guidelines improves function.
Health-related quality of life scores of metastatic pancreatic cancer patients responsive to first line chemotherapy compared to newly derived EORTC QLQ-C30 reference values
Authors: Amin Suvina , Joo Seongjung , Nolte Sandra , Yoo Hyun Kyoo , Patel Nikunj , Byrnes Hilary F. , Costa-Cabral Sara , Johnson Colin D.
Published: May 2022

Background

Metastatic pancreatic cancer (mPC) and its treatments significantly impact health-related quality of life (HRQoL). POLO, a randomized, double-blind, placebo-controlled phase 3 trial evaluated the efficacy of olaparib as maintenance therapy in germline BRCA mutated mPC patients who had not progressed during ≥16 weeks of first-line platinum-based chemotherapy. HRQoL was assessed using the EORTC QLQ-C30. To enhance score interpretation, we derived reference values for treatment-naïve mPC patients from the literature.

Methods

A targeted literature review identified EORTC QLQ-C30 baseline values in treatment-naïve mPC patients. Reference values were calculated by deriving means from studies meeting inclusion criteria, with scores from 0 to 100 (higher scores indicate better QoL/functioning but worse symptoms). For POLO patients, means were calculated using pooled baseline data across study arms.

Results

Four studies met inclusion criteria. Depending on the specific scale, sample sizes ranged from n = 466 to n = 639. Compared to newly derived reference values, POLO patients reported markedly better HRQoL scores at baseline across most scales, with eight scales showing differences of ≥10 points. POLO patients’ HRQoL scores were often close to or better than general population norm data.

Conclusions

This is the first study to systematically derive EORTC QLQ-C30 reference values for mPC. POLO patients had better HRQoL scores than those in the literature and similar to general population data. Comparatively high HRQoL of POLO patients are likely due to effects of prior first-line treatment and resolution of chemotherapy-related symptoms, response shift, or a combination. Newly derived reference values can enhance interpretation of mPC patients’ HRQoL.

Trial registration

The POLO trial was registered on 9 July 2014 with ClinicalTrials.gov as NCT 02184195.
Safety, activity, and pharmacokinetics of camrelizumab in advanced Asian melanoma patients: a phase I study
Authors: Zhou Li , Wu Xiaowen , Chi Zhihong , Si Lu , Sheng Xinan , Kong Yan , Mao Lili , Lian Bin , Tang Bixia , Yan Xieqiao , Wang Xuan , Bai Xue , Li Siming , Wei Xiaoting , Li Juan , Yang Qing , Guo Jun , Cui Chuanliang
Published: May 2022

Background

Anti-programmed cell death receptor-1 (PD-1) monotherapy is the standard treatment for metastatic melanoma in current. Camrelizumab is a humanized IgG4 anti-PD-1 monoclonal antibody whose safety and efficacy have not been reported in advanced Asian melanoma patients.

Methods

This phase I study investigated the safety, activity, and pharmacokinetics of camrelizumab in Chinese patients with advanced melanoma. The study included two phases, the dose-escalation phase (“3 + 3” design at 60 mg, 200 mg, and 400 mg) and the dose-expansion phase.

Results

No dose-limiting toxicities were recorded over the dose-escalation phase, and the maximum tolerated dose was not reached. The most common treatment-related adverse events (TRAEs) in 36 patients were reactive cutaneous capillary endothelial proliferation, followed by rash, fever, hypothyroidism, hyperthyroidism, vitiligo, and fatigue. Five grade 3 or above TRAEs were reported (13.9%), including two cases of elevated γ-glutamyltransferase and blood triglycerides without clinical symptoms, and one liver injury recovered after symptomatic treatment. The confirmed overall response rate was 13.9% (95%CI: 4.7, 29.5%) and disease control rate was 38.9% (95%CI: 23.1, 56.5%). The median progression-free survival was 1.8 months (95%CI: 1.1, 2.4) and the median overall survival was 11.1 months (95%CI: 6.8, 15.4).

Conclusions

Camrelizumab had acceptable tolerability and similar anti-tumor activity compared with other anti-PD-1 antibodies in advanced Asian melanoma patients.

Trial registration

ClinicalTrials.gov identification: NCT02738489. Registered on 14/04/2016, prospectively registered.