bluuebunny/crossref_metadata_2025 huggingface dataset:
Three-Dimensional Speckle Tracking Echocardiography for the Assessment of Cardiac Function in Newborns with Extra- Cardiac Diseases
Authors:   Pediatric Department, Tanta University Hospital, Tanta, Egypt, Elmesiry Asmaa
Published: September 2022

Neonatal heart could be affected by extracardiac diseases as neonatal sepsis, neonatal pneumonia, hypoxic-ischemic encephalopathy. Cardiac function in neonates can’t be accurately assessed using conventional methods. Advanced echocardiographic parameters can be used to evaluate neonatal cardiac function as Tissue Doppler Imaging (TDI) and speckle tracking echocardiography. This study aimed at assessing the role of three-dimensional speckle tracking echocardiography (3D-STE) in detection of subclinical myocardial dysfunction in newborns with common extra-cardiac neonatal diseases. In this work; 100 asymptomatic cardiac newborns with extra-cardiac neonatal diseases were included as a patient group. Fifty healthy newborns of matched age, sex, and weight served as a control group. Laboratory investigations in the form of complete blood count (CBC), liver function test, renal function test, capillary blood gas, serum electrolytes, cardiac troponin I (cTnT-I) and N-terminal Pro-BNP were drawn. Complete echocardiographic evaluation of the left ventricular (LV) function was performed in the form of conventional echo, tissue Doppler imaging (TDI), 2-dimensional speckle tracking echocardiography (2D-STE) and 3-dimensional speckle tracking echocardiography (3D-STE). cTnT-I and N-terminal Pro-BNP levels were significantly higher in the patient group than the control group. Conventional echocardiography showed normal systolic and diastolic function of the LV. Diastolic function (by TDI) was significantly lower in the patient group than control group. 2D-STE and 3D-STE examination showed that there was a significant decrease in all components of strain in the patient group compared to the control group. In conclusion; 3D-STE is a good tool for prediction of silent cardiac dysfunction in newborns with extracardiac neonatal diseases
Echocardiographic Findings in Patients with Transient Ischemic Attacks
Authors:   Department of Internal Medicine, Grand Strand Medical Center, Myrtle Beach, SC, USA, Abdelsayed Nardine
Published: September 2022

Echocardiography has a well-established utility for the detection of intramural thrombi and left atrial enlargement during routine evaluation of cerebrovascular accidents (CVA), however the use of echocardiography in transient ischemic attack (TIA) is much less established. Current guidelines from the American Heart Association (AHA)/American Stroke Association (ASA) recommend echocardiogram in ischemic stroke when cardioembolic source is suspected, but there is less clarity with regards to how results should be interpreted for ongoing patient care. We aimed to examine common echocardiogram findings in patients presenting with TIA. From 2018-2019, we examined all TIA patients over the age of 18 who were discharged from our comprehensive stroke center. Patients were excluded if they were diagnosed with acute stroke, demyelinating disease or intracranial mass found on MRI of the brain, or carotid stenosis greater than 50%. A total of 588 patients were identified and of these, 449 (76.36%) patients who met these criteria underwent transthoracic echocardiography (TTE) as part of their TIA evaluation. 130 (28.95%) of the 449 patients underwent echocardiogram with agitated saline. 2D echocardiogram reports were reviewed for the presence of left atrial size greater than 4 cm, atrial fibrillation, left ventricular thrombus, left atrial thrombus, moderate to severe mitral stenosis, patent foramen ovale, atrial septal defect, vegetation or mass on any valve, new left ventricle function less than 50%, and atrial myxoma. The overall incidence of mitral stenosis, patent foramen ovale (PFO), atrial septal defect (ASD), thrombus, atrial myxoma and vegetation was low and not statistically significant. PFO was discovered in 11 of the 130 (8.46%) agitated saline studies. The analysis showed that 173 of the 449 (38.53%) patients were found to have left atrial size greater than 4 cm. Of the patients with left atrial enlargement, 59 (34.10%) also carried a diagnosis of atrial fibrillation (AF) while 114 of the 173 (65.9%) did not. Ultimately, of patients without known AF, only 6 of 114 (5.25%) were discharged with cardiac monitoring. In summary, echocardiogram in TIA commonly demonstrates left atrial size greater than 4 cm, and only a very small proportion of patients with left atrial enlargement and no known history of atrial fibrillation were assigned to outpatient cardiac monitoring at the time of discharge.
Utility of Thyroid Stimulating Hormone (TSH) in Atrial Fibrillation
Authors:   Department of Internal Medicine of Mercer University School of Medicine. Grand Strand Medical Center, Myrtle Beach, SC, USA, Abdelsayed Nardine
Published: September 2022

Atrial fibrillation (AF) has become increasingly common in the inpatient setting. Current practices in new onset AF include obtaining laboratory values such as thyroid stimulating hormone (TSH) with reflex thyroxine (T4). We aim to prove that such practices rarely change management and should be limited to patients with additional indicators of hyperthyroidism. From January 2015 to August 2021, a total of 59,470 patients that were 18 years and older were identified with an admission diagnosis of atrial fibrillation using the ICD-10 code I48.92. Patients were excluded if their sex or age were not identified and if they had a previous admission for atrial fibrillation. Out of the 54,968 patients admitted with AF, TSH was ordered in 7,444 (13.54%), free T4 was ordered in 2,669 (4.85%), and both in 2,285 (4.16%). Only 29 (0.013%) of the 2,285 patients who had orders for both TSH and T4 were found to have both low TSH and high T4, indicating an overt hyperthyroid state. Overall, of the 7,444 patients with TSH labs drawn, only 404 (5.43%) were discharged on methimazole or Propylthiouracil (PTU). While we recognize the importance of identifying modifiable risk factors, we propose that TSH levels should not be reflexively ordered during hospitalization for patients with new onset AF without further clinical suspicion of thyroid disease.
The Antibiotic Resistance Rates in Multidrug Resistant Acinetobacter Isolates from Microbiological Culture Samples of Adult Patients in Turkey: A Retrospective Study
Authors:   Department of Microbiology, Bandirma Training and Research Hospital, Bandirma, Balikesir, Turkey, Tuna Duygu Kubra , Demirtas Hande ,   Education Unit of Bandirma State Hospital, Balikesir, Turkey
Published: September 2022

Objective: Acinetobacter species lead to extremely serious infections, particularly in hospitalized patients, and in patients with impaired host defense. The high rates of resistance against several antibiotics detected in recent years have created serious issues in treatments of different diseases. We aimed to examine antibiotic resistance profiles of Acinetobacter species isolated from patients who are treated as outpatients in polyclinics or hospitalized in services or intensive care units (ICU), against various antimicrobial therapies. Materials and Methods: Antibiotic resistance of Acinetobacter strains isolated from 533 clinical samples collected between 2017-2021 years in Bandırma State Hospital Clinical Microbiology Laboratory were evaluated retrospectively. The identification of isolates and antibiotic susceptibility tests were performed by BD Phoenix (Becton Dickinson, USA) automated system. Results: Most of Acinetobacter strains were isolated from respiratory secretions (32.5%) and from urine (24.4%). Of species, 63.8% were Acinetobacter baumannii, 34.9% Acinetobacter baumannii complex, 1.1% other Acinetobacter spp., 0.2% Acinetobacter lwoffii. Resistance rates to antibiotics were found as following: ciprofloxacin 91.1%, meropenem 91.3%, imipenem 89.2%, gentamicin 82.5%, trimethoprim-sulfamethaxasol 78.6%, amikacin 66.3% (highest in 2020), aztreonam 99.0% (significantly decreased in 2020), ceftriaxone 100%, ampicillin 100%, amoxicillin-clavulanate 100%, ertapenemicin 100%, cefuroxime 100%, netilmicin 62.5%, nitrofurantion 100%, colistin 4.7% and levofloxacin 87.1%. The samples collected from patients hospitalized in service and ICU were found more resistant against Ciprofloxacin, Levofloxacin, Meropenem, Imipenem, Trimethoprim/Sulfamethoxazole, Gentamicin and Amikacin (P<0.0001). Conclusion: Colistin resistance against Acinetobacter infections was observed to be low, hence colistin could be utilized in treatments. Infection control measures have to be taken in services and ICU, and rational antibiotic use policies should be applied so as to prevent the spread of infection
Merkel Cell Carcinoma: Case Report and Bibliographic Review
Authors:   Digestive Surgeon, Fellow of American College of Surgeons (FACS), Assistant of Discipline of Surgical Technique and Surgical Habilities of Faculdade de Medicina da Universidade Cidade de São Paulo (FM-UNICID), São Paulo/SP-Brazil, Gentile Kleber de Almeida , Custódio dos Santos Renata de Oliveira Belo ,   Graduation in Medical School of São Paulo City University (FM-UNICID), São Paulo/SP-Brazil, Silva Pinto Danielle da ,   Graduation in Medical School of São Paulo City University (FM-UNICID), São Paulo/SP-Brazil, Souza Flávya Muniz ,   Graduation in Medical School of São Paulo City University (FM-UNICID), São Paulo/SP-Brazil, Oliveira Johnen Ana Carla de ,   Graduation in Medical School of São Paulo City University (FM-UNICID), São Paulo/SP-Brazil
Published: September 2022

Introduction: Merkel cell carcinoma (MCC) is characterized as a malignant trabecular neoplasm of the skin. The most common sites of lesions are areas
frequently exposed to the sun, thus regions such as head, neck and upper limbs. The aim of this study is to report the clinical case of a female patient assisted
in a Teaching Hospital in the State of São Paulo, with a lesion in the left gluteal region, unusual to what is found in the literature.
Case Report: An 87-year-old female patient, who underwent excisional biopsy of a lesion on her left buttock, with an anatomopathological (AP) diagnosis
of MCC, was also submitted to a control image, which showed a new lesion in the lymph node chain, and underwent a new surgical procedure, which was
unsuccessful.
Discussion: Most patients have local disease, but MCC has a high rate of metastasis, with the main sites of secondary lesions being skin (28%), regional lymph
nodes (27%), liver (13%), lung (10%), bone (10%), and brain (6%). As evident in the literature, the diagnosis of the patient was made by immunohistochemical
analysis, through the positive expression of CK20, chromogranin and synaptophysin, and the extent of disease evaluated by computed tomography. Wide
local excision and adjuvant radiotherapy remain the mainstay of MCC treatment, but many studies show promising results with the use of monoclonal
antibodies, such as avelumab, which was not used in the case reported. Although MCC is rare, despite the high recurrence rate and poor prognosis, early
diagnosis and treatment are essential to prevent and combat the progression of metastatic disease, the main factor in the decrease in overall survival of patients.
Conclusion: MCC is still a challenge for the medical field, since this neoplasm has a high potential for recurrence and metastasis. However, late diagnosis
and limited and delayed treatment contribute to a higher lethality rate.
Dunbar Syndrome Treated by Laparoscopic Surgery
Authors:   Digestive Surgeon, Fellow of American College of Surgeons (FACS) Assistant of Discipline of Surgical Technique and Surgical Abilities of Faculdade de Medicina da Universidade Cidade de São Paulo (FM-UNICID) São Paulo/SP Brazil, Almeida Gentile TCBCD Joao Kleber de , Mussalem Santos Mariana ,   Graduation in Medical Science of the Faculty of Medicine of the University of São Paulo (FM-UNICID) São Paulo/SP Brazil, Custódio dos Santos Renata de Oliveira Belo ,   Graduation in Medical Science of the Faculty of Medicine of the University of São Paulo (FM-UNICID) São Paulo/SP Brazil, Boaventura Fernanda Moreira ,   Graduation in Medical Science of the Faculty of Medicine of the University of São Paulo (FM-UNICID) São Paulo/SP Brazil, Oliveira Johnen Ana Carla de ,   Graduation in Medical Science of the Faculty of Medicine of the University of São Paulo (FM-UNICID) São Paulo/SP Brazil, Silva Pinto Danielle da ,   Graduation in Medical Science of the Faculty of Medicine of the University of São Paulo (FM-UNICID) São Paulo/SP Brazil, Braun Soave Ana Sophia ,   Graduation in Medical Science of the Faculty of Medicine of the University of São Paulo (FM-UNICID) São Paulo/SP Brazil, Yuji Tanaka Daniel ,   Graduation in Medical Science of the Faculty of Medicine of the University of São Paulo (FM-UNICID) São Paulo/SP Brazil
Published: September 2022

Median arcuate ligament syndrome (MALS) or Dunbar syndrome is a rare condition resulting from compression of the celiac trunk by the median ligament at the level of the diaphragmatic crus. Abdominal tomography contributes to the diagnosis by demonstrating the level of obstruction and the presence of collateral arterial circulation in the gastroduodenal region, typical of the disease in chronic cases. The therapeutic options, although few, find in the laparoscopic surgical treatment the best option for releasing the muscle fibers in the arcuate ligament region. We report a rare case of a 38-year-old woman diagnosed with MALS successfully treated laparoscopically.
Genetic Signatures of Chromosome 20 Mosaicism in Recurrent Pregnancy Loss
Authors:   Seeds of Innocence Maternity and Infertility Centre Pvt Ltd, New Delhi, India, Agarwal Gauri , Razdan Alpana ,   Genestrings Diagnostic Centre Pvt Ltd, New Delhi, India, Samal Rakesh ,   Seeds of Innocence Maternity and Infertility Centre Pvt Ltd, New Delhi, India, Sharma Vandana ,   Genestrings Diagnostic Centre Pvt Ltd, New Delhi, India, Koul Shikha ,   Genestrings Diagnostic Centre Pvt Ltd, New Delhi, India, Mishra Vandana ,   Seeds of Innocence Maternity and Infertility Centre Pvt Ltd, New Delhi, India
Published: September 2022

Recurrent pregnancy loss (RPL) causes an immeasurable physical, emotional, and economical impact on the couple. RPL is a complicated challenging scenario in front of gynaecologists working in the area of reprogenomics. Chromosomal aneuploidy and mosaicism are common causes of sporadic early pregnancy loss and play an important proportion in RPL in patients undergoing in vitro fertilization (IVF). In a single-center case series, we report five cases of RPL after implantation of embryos with mosaicism of chromosome 20. The female partners were of advanced maternal age and had a history of previous miscarriages. The couple’s blood karyotype reports were normal and there was no family history of any inherited disease. The chromosomal aneuploidies were screened in day 5 embryos with good morphological grades. The day five trophectoderm biopsies were subjected to Preimplantation genetic screening (PGS) using the next-generation sequencing (NGS) technique. The couples were genetically counseled and written informed consents were taken before implantation explaining all the associated risks. All the clinical parameters were normal and the patients were in close observation with regular follow-up throughout the treatment. These cases had chromosome 20 mosaic embryo transfer resulting in fetal loss in first trimester of pregnancy. Our findings strongly suggest that chromosomal mosaicism in embryos is one of the leading causes of RPL in females with previous miscarriages and advanced maternal age
Estimation of Tolnaftate in Pharmaceutical Preparations Samples
Authors:   Environmental College, Department of Technology, University of Mosul-Iraq, Ahmed Nief Rahman
Published: September 2022

A simple, accurate, precise, rapid, economical and sensitive ultraviolet spectrophotometric method has been developed for the determination of Tolnaftate in pharmaceutical preparations which shows maximum absorbance at 260 nm in distilled water. Beer’s law was obeyed in the range of 1 -14 μg/ ml ,with molar absorptivity of 2.183×104 L.mol-1.cm-1 , relative standard deviation of the method was less than 1.8%, and accuracy (average recovery %) was 100 ± 1.0. No interference was observed from common excipients and additives often accompany with Tolnaftate in pharmaceutical preparations .The method was successfully applied to the determination of Tolnaftate in some pharmaceutical formulations (creams and topical solutions) samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Tolnaftate in true samples.
Effective Organization Strive to Focus on the Behavioral Patterns of Their Employed
Authors:   MS management, International University Islamabad IIUI, Pakistan, Husssain Riaz
Published: September 2022

Effective organizations strive to focus on the behavioral patterns of their employees. They are designed to develop human behaviors that are best suited for the effectiveness of an organization. Organizational justice is one of the main key factor that invest in developing a positive behavior of the employees towards their organization as well as their colleagues that in turn add up to the effectiveness of an organization. This research extracts the theoretical support from equity theory of Adam smith, Justice judgmental Model theory of Leventhal, Social Exchange theory of George Homan and Social System theory of Chester Bernard. The study is intended to empirically assess the impacts of organizational justice on organizational effectiveness with a mediating role of organization citizenship behavior in higher education institutions of Pakistan. The researchers suggests that criteria of effectiveness in institutions is the same as that of an organization. Using positivists’ approach 313 questionnaires were distributed in academic staff of five different universities located in the federal territory of Islamabad. Collected data was analyzed both in descriptive and inferential manner with appropriate statistical tools through statistical package for social sciences software SPSS version 22. The mediating role of Organization Citizenship Behavior was checked through Baron and Kenny four step model for mediation. This research has contributed towards the theory as well as given a practical insight into the institutional effectiveness. In the research data is collected from the faculty members from of different universities namely, International Islamic University Islamabad, Quaid e Azam University Islamabad, COMSATS Islamabad, National University of Modern Languages NUML Islamabad, and National University of Computer and Emerging Sciences FAST Islamabad campus. The results of the research shows that organizational justice is an important aspect that contribute towards the organization citizenship behavior. Organization citizenship behavior is the fundamental contributor towards the Organizational Effectiveness in higher education institutions of Pakistan.
Lemierre’s Syndrom Resulting from Cholesteatomatous Otitis Media and Mastoiditis: A Case Report
Authors:   Resident Physician in Otorhinolaryngology, Department of Otorhinolaryngology, Head and Neck Surgery, Ibn Sina University Hospital, Rabat, Morocco, Benkhraba Niema
Published: September 2022

Lemierre’s syndrome is a rare and in some cases fatal thrombophlebitis of the internal jugular vein (IJV). It usually follows acute oropharyngeal or otologic infections in healthy, young children. Fusobacterium necrophorum is the most common bacteria that causes Lemierre’s syndrome, whereas various microorganisms are reported. We report a case of Lemierre’s syndrome secondary to chronic otitis media, which remains a rare occurrence of a very seldam disease.
dimensão freireana da formação do educador ambiental na “ComVivência Pedagógica”
Authors: Noeli Borek Granier  , Mauro Guimarães
Published: September 2022

A “ComVivência Pedagógica” é uma proposta teórico metodológica de formação de educadores ambientais em construção pelo grupo de Pesquisa GEPEADS/UFRRJ, que se encharca das concepções educacionais de Paulo Freire. Nesse artigo apresentamos essa dimensão freirerana que está presente em todas as etapas de desenvolvimento da proposta formativa.
música geradora na formação docente em Educação Ambiental Dialógica
Authors: João Batista de Albuquerque Figueiredo
Published: September 2022

Neste ensaio dialógico, realizamos uma pesquisa dialógica, com vistas a catalogar temas de interesse à gruposem formação docente, através de Músicas Geradoras. Apresenta um relato da utilização e potência da música, enquanto linguagem capaz de impulsionar reflexões, mapear saberes de experiência feito, com intencionalidade educativa, proporcionar tomada de consciência e conscientização.Constatamos que a música favorece a escuta amorosa, o surgimento de metáforas geradoras de práxis. Nesse exemplo, entrelaçamos a música Paciência, de Leninecom o capítulo primeiro do Pedagogia do Oprimido, de Paulo Freire. Dasvárias narrativas, emergiram falas sobre: entremear calma/serenidade diante do cotidiano opressor; que podemos nos opor a lógica do mercado. Alertaram sobre o amor-próprio, autocuidado, a pressa da modernidade, que outras lógicas são possíveis em sala de aula e no mundo,dereconhecermos que somos corpo-alma. A música pode se tornar práxis pedagógica que potencializa práxis social.
Do high PaCO2 levels during discharge from the hospital predict medium-term mortality in chronic respiratory failure patients without domiciliary non-invasive mechanical ventilator?
Authors: ÇELİK Deniz , YILDIZ Murat , KURT Hasret Gizem , SAYMAZ Zeynep Tilbe
Published: September 2022

Aim: Long-term domiciliary use of a non-invasive mechanical ventilator (NIV) is a controversial form of therapy for patients with chronic obstructive pulmonary disease (COPD) and moderate hypercapnia. The present research attempted to examine hospital admissions, hospitalizations, and medium-term (6-8 months) mortality in a group of patients with compensated but moderate hypercapnia who were discharged from our clinic without a domiciliary NIV.
Material and Method: The sample of this retrospective, observation-based cohort study consisted of compensated hypercapnic cases that were hospitalized in our Pulmonology Intensive Care Unit (ICU) between 01.01.2019 and 12.31.2020.
Results: A total of 245 patients discharged with high partial pressure of carbon dioxide (PaCO2) levels between 01.01.2019 and 12.31.2020 were included in the study. While 58% of the cases were males (n=142), we found the mean age of the patients to be 71.89±12.63 years. The findings yielded no significant differences between the groups by sex, use of NIV during hospitalization, number of days of NIV use during hospitalization, use of LTOT or Oxygen tube at home, and intubation history before ICU admission (p>0.05). Similarly, we could not conclude significant differences between the groups by hospitalization, discharge, and follow-up arterial blood gas (ABG) parameters. Yet, the rates of congestive heart failure, coronary artery disease, and atrial fibrillation were significantly higher in the mortality group (p=0.017, p=0.032, and p=0.002, respectively). Besides, high PaCO2 levels versus mortality rates at 1, 3, 6, 8, and 12 months and in the entire follow-up period were subjected to the ROC analysis. Accordingly, when accepting 50.25 mmHg as the cut-off value for determining the 8-month mortality for discharge PaCO2 levels, we calculated the sensitivity to be 78.6% and the specificity to be 43%.
Conclusion: Overall, it is highly convenient to consider the possible positive effects of NIV therapy on mortality among patients with heart-related diseases and with moderate hypercapnia (PaCO2>50 mmHg) at discharge.
Retrospective evaluation of pediatric trauma patients: a single-center experience of a tertiary pediatric intensive care unit
Authors: VAROL Fatih , CAN Yasar Yusuf , ÖZGÜNAY Büşra , CENGİZ Mehmet , ALTAS Ugur , GÜVEN Şirin , CAM Halit
Published: September 2022

Aim: Due to the rapid development in pediatric critical care medicine, some past studies suggested that pediatric trauma patients have better outcomes such as lower mortality and lower length of hospital stay in the pediatric intensive care unit (PICU). In this study, we aim to describe the demographic, clinical features, mechanisms of injury, and outcomes of children hospitalized in our pediatric intensive care unit due to trauma.

Material and Method: We performed a retrospective evaluation of 60 pediatric trauma patients (between 0 and16 years of age) admitted to the PICU at University of Health Science, Sancaktepe Sehit Prof. Dr. İlhan Varank Training and Research Hospital from August 2020 to February 2022.

Results: A total of 60 pediatric trauma patients were followed up in our PICU. The median age of patients was 17 (0-724) months with a preponderance of male cases (n:38, 63.3%). The median duration of hospitalization in PICU was 6 (1-46) days. According to the trauma type, the majority of the injuries were falling from a height (n:37, 61.7%).

Conclusion: We would like to draw attention to the fact that head traumas due to falling were so common and also affect mortality. The lactate and the lactate/albumin ratio ​​of patients who developed mortality were significantly higher. Although there are studies on the association of lactate/albumin ratio with mortality in critically ill pediatric patients, we could not find any data on this issue in pediatric trauma patients in the literature. Our study will contribute to the literature on the relationship between lactate/albumin ratio and mortality in pediatric trauma patients. We suggest that the relationship between lactate/albumin ratio and mortality should be investigated in pediatric trauma patients with larger case numbers.
Outcomes of de novo extended-release tacrolimus use (Advagraf®) in kidney transplantation: 1-year, single-center experience
Authors: TÜRKMEN SARIYILDIZ Gülçin , DEMİR Mehmet Emin , ERCAN Zafer , SÖZENER Ulaş , ÇİÇEK Canan , ARSLAN Aykut İlker , ÖZŞEKER Fatma Necla
Published: September 2022

Aim: Once daily extended-release tacrolimus (tac-ER) was introduced to support medication adherence in kidney transplant (KTx) recipients, with similar efficacy to immediate-release tacrolimus (tac-IR). However, most of the experiences regarding tac-ER efficacy were obtained from the switches from tac-IR to tac-ER in kidney transplant recipients (KTRs). In this study, we aimed to demonstrate 1-year outcomes of de novo use of tac-ER in KTRs.

Material and Method: This single-center retrospective study included 72 de novo KTRs between January 2020 and January 2021. KTRS were divided into two groups who received a tac-ER or tac-IR. 1-year allograft functions, allograft survival, daily doses of tacrolimus in milligram/day and milligram/kg/day, trough levels, and acute rejection episodes were compared between the two groups. The factors that might have an impact on allograft functions and acute rejection episodes also were investigated.

Results: A total of 69 de novo kidney allograft recipients (30 recipients in the tac-ER and 39 recipients in the tac-ER groups); were evaluated. Three KTRs were excluded due to the deaths within the early posttransplant period. Serum creatinine and tacrolimus trough levels were similar for 12 months after transplantation (p>0.05). More daily tacrolimus doses (in milligram/day and milligram/kg/day) were required to obtain a targeted trough level up to 3 months in the tac-ER group. Acute rejection rates also were found similar between the two groups (p=0.281). Univariate regression analysis demonstrated that higher total daily tacrolimus doses within a posttransplant month 1 may (milligram/kg/day) have an impact on lower acute rejection episode(s) independent of tacrolimus trough levels (p=0.02).

Conclusion: De novo use of extended-release tacrolimus Advagraf® is as effective as immediate-release tacrolimus in preventing acute rejection episode(s) and provides satisfactory 1-year allograft function and survival.
The relationship between anti mullerian hormone level and endometrial polyp frequency in patients with polycystic ovary syndrome
Authors: AYAR MADENLİ Asena , ÖZ İnci , GÜRBÜZ Tuğba
Published: September 2022

Aim: This study aimed to conduct a case-control study to determine the relationship between serum anti mullerian hormone (AMH) levels and frequency of endometrial polyp in women with polycystic ovary syndrome (PCOS).

Material and Method: Patients with endometrial polyps (n=55) were included in the study group. The control group was selected from women without endometrial polyps (n=49). The relationship between the case and control groups was studied using the chi-square test to check the AMH levels and endometrial polyps.

Results: The participants’ age and body mass index (BMI) were 28.20±3.08 and 25.45±2.25, respectively. There was a statistically significant association between AMH levels and endometrial polyp (p-value 0.05).

Conclusion: This research showed that the frequency of endometrial polyps increases with higher AMH levels in PCOS patients.
IL-35 levels and their association with thyroid function tests in Hashimoto’s thyroiditis
Authors: İNAN Osman , KARAKURT Feridun , KOŞAR Ali
Published: September 2022

Aim: In this study, it was aimed to examine interleukin-35 (IL-35) levels and their association with thyroid function tests in Hashimoto’s thyroiditis (HT).

Material and Method: Included in the study were 128 individuals, between 18 and 65 years of age, who had been newly diagnosed with HT (euthyroid, subclinical hypothyroidism and overt hypothyroidism) and 38 health controls who had no known diseases or drug use.

Result: No significant difference was determined between the groups in terms of the IL-35 levels (p=0.285), although in the in-group comparisons, the IL-35 levels were found to decrease progressively towards overt hypothyroidism. In the in-group comparisons, however, a statistically significant difference was determined between the control group and the overt hypothyroidism group (550.05±411.50 vs. 369.80±253.33; p=0.046). When the patient groups were grouped according to their thyroid stimulating hormone values, a significant difference was determined between the groups with a threshold value of ≥6 uIU/ mL and those below it, in terms of the IL-35 levels (p=0.043). When two groups were created, comprising those with a threshold value of ≥10 uIU/mL and those below it, it was observed that there was a more significant difference between the groups in terms of the IL-35 levels (p=0.024). As a result of the correlation analysis performed by taking into account the controllable factors (smoking, diabetes mellitus, hypertension, and body mass index), a low-significant correlation was determined between the IL-35 levels and antithyroid peroxidase (p=0.029).

Conclusion: In this study, it was determined that the IL-35 levels, an antiinflammatory cytokine involved in HT, decreased progressively from the euthyroid patient group towards the overt hypothyroidism group.
Evaluation of real-life data in patients with severe eosinophilic asthma treated with mepolizumab
Authors: ATEŞ Hale , AKSU Kurtuluş , KOCA KALKAN İlkay , TOPEL Musa , DEMİR Senay , YESİLKAYA Selma , NAZİK BAHCECİOGLU Sakine
Published: September 2022

Aim: We aimed to evaluate the efficacy of mepolizumab on asthma exacerbations, blood eosinophils, oral steroid dependence, and asthma control.

Material and Method: This study is a clinical observational study created from real-life data obtained by retrospective analysis. Patients who were initiated subcutaneous mepolizumab at a dose of 100 mg every four weeks in our clinic and received treatment for at least 16 weeks were included in the study.

Result: Thirty-four patients with severe eosinophilic asthma were included in the study. We found that mepolizumab treatment resulted in a decrease in the number of asthma exacerbations, the need for maintenance oral corticosteroid, blood eosinophil counts, and improvement in lung functions and asthma control test scores in patients with severe eosinophilic asthma. At 6 months the rate of responders and super responders to mepolizumab treatment was 75% and 17.9%, respectively, and the overall response rate was 92.9% as a result. In the first year of treatment, the rate of super-responders increased to 58.3%, and the overall response rate was 91.7%. The rate of second-year responders and super-responders was 7.7% and 84.6%, respectively, and the overall response rate was 92.3%. At 3 years, the overall response rate had increased to 100%.

Conclusion: The results of our single-center study, in which we evaluated the results of mepolizumab treatment in patients with severe eosinophilic asthma, confirmed the clinical, hematological and functional findings published by previous studies in a real-life setting.
Biotechnology for medical diagnosis
Authors: Yaseen Arshed H. , Al-Hasani Halah M. H. , Alelyan Umer Abdullah Ahmed
Published: September 2022

Biotechnology is broadly defined as, “using organisms or their products for commercial purposes” encompasses a wide range. Since the beginning of time, people have used (traditional) biotechnology. Wheat, brew alcohol, and breed food crops and domestic animals have all been made using this grain. Molecular biology’s most recent breakthroughs, on the other hand, have given new life to biotechnology’s relevance and potential. Biotechnology has become a hot topic among the general public. There’s a good chance that modern biotechnology will have a big impact on the environment. Small-molecule (chemical) medications produced by well-known pharmaceutical companies have traditionally accounted for the vast majority of human illness treatments. The current article discussed.
Kohesi Pada Lirik Lagu Album Gajah Karya Tulus sebagai Alternatif Bahan Ajar di Sekolah Menengah Atas
Authors: Widayati Sri , Ningsih Nur Mei , Aditia Heru
Published: September 2022

The problem discussed in this study is the cohesion contained in the lyrics of the song entitled Gajah album by Tulus. The lyrics of the song will be used as alternative teaching materials in high school. The purpose of this study is to describe the cohesion contained in the lyrics of the album's songs and determine whether or not the album is worthy of being used as an alternative teaching material in high school. The method used is descriptive qualitative. The results of this study found 59 cohesion data on grammatical and lexical aspects which include references, substitutions, ellipsis, conjunctions, repetitions and synonyms. From the aspect of teaching materials, the album's song lyrics have met the criteria so that they are worthy of being used as alternative teaching materials for students in high school.
О месте, роли и значении фундаментальной экономической теории в современной России
Authors: Цветков В.А.
Published: September 2022

На фоне поворотных моментов российской истории представлен непростой путь становления и развития российской экономической науки. Исследование проблем рыночной экономики в настоящий момент является важной составной частью современной фундаментальной экономической науки. Вопросы исследования рыночной экономики, включая проблемы поиска адаптационных механизмов сглаживания провалов рынка и формирования эффективной конкурентной среды, не только актуальны с научной точки зрения, но и носят прикладной и практический характер.
Тренды экономической науки: дискуссии о путях российской модернизации XIX-XX веков
Authors: Мау В.А.
Published: September 2022

В статье анализируется эволюция экономической мысли в России на протяжении XIX-XX вв. Рассматриваются глобальный контекст, в котором складывалась российская экономическая наука, и те цели, которые перед ней стояли. Дается представление о том, как формировались взгляды на развитие страны, экономическую политику, роль государства в экономике. Показано, что в начале XIX в. доминирующий характер носили идеи классического экономического либерализма. Раскрывается вопрос формирования проблемы догоняющего развития и ее влияние на экономическую научную мысль в России. Описаны основные направления развития взглядов на управление экономикой под воздействием ее усложнения в процессе развития промышленности. В частности, усиление роли государства и формирование приоритетов экономической политики. В то же время подчеркивается, что к концу XX в. методы государственного управления экономикой пережили тяжелый кризис, связанный, в том числе, и с распадом советского блока. Однако уже в начале XXI в. под влиянием ряда объективных и субъективных причин роль государства в управлении экономикой вновь стала увеличиваться.
Экономика качества – важнейшее направление развития экономической науки
Authors: Окрепилов В.В.
Published: September 2022

В статье на обширном фактическом материале показан путь становления науки о качестве, ее формирования и развития в Российской академии наук. Рождение Российской академии наук предопределило развитие основных элементов научного направления «Экономика качества»: метрологии, стандартизации, управления качеством. В числе главных достижений – создание многоуровневой системы управления качеством, участие в формировании стратегических планов развития Санкт-Петербурга и Северо-Западного федерального округа, разработка уникальных методик оценки качества жизни, создание многоуровневой системы подготовки кадров по экономике и управлению качеством.
O USO DAS CRIPTOMOEDAS COMO DINHEIRO E SUA COEXISTÊNCIA COM MOEDAS FIDUCIÁRIAS
Authors: Billig Osvaldo Alencar , Grzybovski Gustavo Henrique
Published: September 2022

O mercado internacional de criptomoedas teve um aumento de capitalização de 4 bilhões de dólares americanos em 2015 para mais de 2,5 trilhões em 2021, observado o expressivo aumento de valorização e popularização nos últimos anos, torna-se relevante compreender quais os problemas que estas moedas estão solucionando, que motivaram sua criação e hoje estruturam seu crescente número de usuários.  O artigo analisou o papel do dinheiro em uma economia, verificando a partir disso, se as moedas digitais estão cumprindo as três principais funções do dinheiro e a possibilidade de coexistência entre estas e moedas fiduciárias em um mesmo território legal. O estudo foi por meio da abordagem qualitativa e natureza básica, compreendendo e conectando os dados disponibilizados pelas fontes.  Constatou-se que os ativos podem coexistir com moedas fiduciárias e que estes servem para suplementar uma economia e servir de alternativa a uma população que busca deste liberdade e anonimato.
Haber Değerlerini Sorgulamak: Anaakım Gazetelerde Engelli Haberleri
Authors: YÜCE Erman
Published: September 2022

Haber değerinin ne olduğu, evrenselliği, ölçümü vd. gazetecilik çalışmalarında önemli bir alan oluşturmaktadır. Çalışmada, haber değerinin haberlere içkin olan, evrensel, değişmez bir özellik değil, gazetecilik alanının aktörleri tarafından (atfedilen) verilen, yerel özellikler de barındıran, tarihsel olarak değişen, dinamik bir özellik olduğunu varsayılmaktadır. Bu çerçevede çalışma, anaakım gazetelerin haber değeri anlayışını temsil tercihlerine dayalı olarak ortaya koymak üzere, 2015 yılında, 3 Aralık Dünya Engelliler Günü’nde anaakım, ulusal, günlük, en çok satan ilk 15 gazetede yer alan reklam vb. dahil tüm öğelerin (437 sayfa, 728.072 cm²) nicel ve nitel analizine dayanmaktadır.

Çalışmada cari haber değerlerinin özelliklerini sorgulamak üzere engelli haberleri ile anaakım gazetelerin bütün öğeleri nicel ve nitel verilerin bütüncül bir yaklaşımla karşılaştırılmıştır. Araştırma sonuçlarına göre bu gazeteler, sayfalarının önemli bir kısmını reklama ayırdığından habere sınırlı yer ayırabilmektedir. Bu sınırlı alandaki haberlerin dağılımının temsil ve kamu yararı açısından sorunlu olduğu anlaşılmaktadır. Araştırmanın bulguları en çok haber olmaları beklenen gün bile, engellilere temsil/haber değeri verilmediğini, 432 sayfanın haber değeri tartışmalı kişi ve konulara ayrıldığı, yaklaşık sadece 5’inin (yüzde 1) engellilerle ilgili haberlere ayrıldığını göstermiştir. Araştırmanın bir diğer sonucu bu 5 sayfada yer alan 39 haberin, engellilerin toplumun sıradan bir üyesi gibi ele alınmaması, engellilerin kurban, toplumdan yalıtık, tekil bireyler olarak sunulması, engellilerin sorunlarının (bazen başarılarının) sosyal boyutlar göz ardı edilerek kişiselleştirilmesi nedeniyle haber değeri açısından sorunlu olduğudur
REKLAMCILIK ÖNLİSANS PROGRAMI ÖĞRENCİLERİNİN YARATICILIĞA İLİŞKİN METAFORLARI
Authors: ÖZAYDIN Elvan
Published: September 2022

Bu araştırma reklamcılık programı öğrencilerinin yaratıcılık kavramına ilişkin algılarını, metaforlar aracılığıyla ortaya çıkarmak amacıyla yürütülmüştür. Araştırmanın çalışma grubunu Amasya Üniversitesi Sosyal Bilimler Meslek Yüksekokulu, Reklamcılık Programının 2019 yılı bahar döneminde ilk defa “yaratıcı düşünce yöntem ve teknikleri” dersi alan birinci sınıf öğrencileri oluşturmaktadır. Reklamcılık programı birinci sınıf öğrencilerinin seçilme amacı ise, yaratıcılık becerisinin meslekleri için aranan önemli bir beceri olmasıdır.

Nitel bir çalışma olan araştırmanın deseni olgubilimdir (fenomenoloji). Toplanan verilerin çözümlemesinde içerik analizi yöntemi kullanılmıştır. Öğrencilerin “Yaratıcılık … gibidir. Çünkü …” şeklinde verilen cümleleri tamamlamaları istenmiştir. Katılım gösteren öğrencilerden yaratıcılık kavramına ilişkin algılarını ortaya koyan bir metafor üretmeleri beklenmiştir. Dağıtılan 54 veri toplama aracından 50 tanesi değerlendirmeye tabi tutulmuştur.

Araştırma sonucunda reklamcılık programı öğrencilerinin yaratıcılığı nasıl algılandıklarına ilişkin ürettikleri metaforlar gerekçeleriyle değerlendirilerek, yedi farklı kategoride gruplandırılmıştır. Metaforların kategoriler bazında dağılımı; değişim/dönüşüm (14), özgürlük (11), özgünlük (8), keşfetmek (6), sonsuzluk (5), belirsizlik (4), umut (2) şeklindedir. Öğrencilerin en çok ürettiği metaforlar; gökyüzü (3), özgürlük (3), bebek (3), kuş (3) olarak belirlenmiştir. Araştırma bulguları öğrencilerin yaratıcılığı genel olarak olumlu simgelerle betimlerken, en çok değişim/dönüşüm, özgürlük ve özgünlük kaynağı olarak gördüklerini ortaya koymaktadır. Bu sonuçların yaratıcılık eğitimleri için yol gösterici olduğu söylenebilir.
Tv Dizilerinde İntikam Söylemi: “Ezel” Dizisi Üzerine Bir İnceleme
Authors: KOÇAK Mevlüt  Can , KALAFAT ÇAT Arzu
Published: September 2022

Kitle iletişim araçları içerisinde yaygın kullanım alanı bulunan televizyon; haber ve bilgi verme, eğitme, eğlendirme, kamuoyu oluşturma gibi işlevlerinin yanı sıra izleyicilerin algıları, tutumları, değer yargıları ve davranış biçimleri üzerinde etkili olabilen, toplumsal gerçekliğin oluşumuna katkı sağlayabilen oldukça güçlü bir araçtır. Televizyonda yer alan söylemler izlerkitlenin zihinlerine ekilerek zamanla meşruluk kazanmaktadır. Bu bağlamda televizyonda yaygın ve tekrarlı olarak sunulan şiddet ve saldırganlık içeren söylemler bu tür düşünce ve davranışların toplum tarafından kanıksanmasına sebebiyet verebilmektedir. Televizyon programları içerisinde en fazla izlenme oranına sahip tür olan diziler; temsiller, anlamlar ve söylemler yoluyla ideoloji ve tutumların sanatsal cazibe ortamında izleyicilere aktarımını sağlamaktadır. Bireyin haksızlığa uğraması ya da uğradığını düşünmesi sonucunda geliştirdiği kişisel tepki şeklinde tanımlanan intikam, şiddet ve saldırganlık içeren sorunlu bir davranış olarak kabul edilmekle birlikte dizilerde sıklıkla vurgulanmaktadır. Bu çalışmada 2009-2011 yılları arasında Show TV ve ATV kanallarında yayınlanan Ezel adlı dizide yer alan intikam söylemi Van Dijk tarafından geliştirilen söylem analizi yöntemi kullanılarak incelenmiştir. Çalışma sonucunda dizinin intikam teması üzerine kurulu olduğu ve intikam söyleminin yaygın şekilde kullanıldığı görülmüştür. Ayrıca dizinin retoriğinin adalet ve eşitlenmenin ancak intikam yoluyla mümkün olabileceği söylemi üzerine kurgulandığı sonucuna ulaşılmıştır. Medyanın toplumsal ideoloji ve bilinç üzerindeki etkisi bağlamında değerlendirildiğinde dizide yoğun biçimde yer alan intikam söyleminin izlerkitlenin hak ve adalet anlayışını olumsuz etkileme potansiyeli bulunmaktadır.
Modern, Post-modern, Küresel Dönüşüm Süreçlerinde Dinin Durumu: Din Kuramlarına Eleştirel Katkı
Authors: CİZRELİ Bahattin , ÖZYURT Cevat
Published: September 2022

Sosyal bilimler literatüründe din olgusunu konu edinen çalışmaların odak noktası, modernleşme ile geleneksel sosyal kurumlarda gerçekleşen köklü dönüşüm olmuştur. XIX. ve XX. yüzyıl sosyal bilimlerindeki egemen yaklaşım, din ile modernleşme arasında gerilimli bir ilişki olduğudur. Sosyal değişmeye bağlı olarak varoluşsal anlam arayışının ve güvenliğin kaynağı olarak din, diğer sosyal kurumlar gibi form değiştirmektedir. Din olgusunu bir analiz konusu olarak merkeze alıp sosyal değişmeyi irdeleyen kimi yaklaşımların temel zaafı, sosyal örüntülere değil görüntülere odaklanmasıdır. Temsillerin değişimini değil toplumlar tarihinin yakın dönemdeki temel kavşaklarında dinin/kutsalın geçirdiği dönüşümü ele almak, sosyal değişmenin yapısal özellikleriyle ilişkili teorik bir çerçeve çizme imkânı sağlayacaktır.

Bu çalışmanın amacı, din olgusunun büyük sosyal değişme süreçlerinde yaşadığı dönüşümlerin ana hatlarını ortaya koyarak yeni teorik yaklaşımlara katkı sağlamaktır. Makalenin birinci kısmında radikal bir kültürel değişme olarak modernitenin, ikinci kısmında post-modernitenin, üçüncü kısmında ise küreselleşmenin etkileri karşısında dinin/kutsalın gösterdiği reaksiyonlar ele alınmaktadır. Son kısımda ise dinin/kutsalın değişimini açıklamaya çalışan kavramsallaştırmaların imkân ve sorunları tartışılmaktadır.
Sosyal Medyada Sharenting Kavramı ve Ulusal Mevzuatta İncelenmesi
Authors: ERDEM Meryem Işıl
Published: September 2022

Geleneksel medyadan, sosyal medya çağına geçilmesi ile birlikte sosyal medya platformları hayatımızda önemli bir yer kaplamaya başlamıştır. Sosyal medya mecralarında ortaya çıkmaya başlayan popüler kültür ise toplumu farklı açılardan etkisi altına almaktadır. Özellikle, son yıllarda sosyal medyanın kullanımının artması ve yaygınlaşması toplumda sosyolojik ve psikolojik değişimler yaratmıştır. Bu değişimler ebeveyn-çocuk ilişkilerine de yansımaktadır. Günümüzde ebeveynler, çocuklarını ve onların özel anlarını sosyal medya platformlarında paylaşmaktadır. Bu durumun hukuk dünyasına yansıması ise kaçınılmaz olmuştur. Bu çalışmada, ebeveynleri tarafından küçük yaşlarda dijital ayak izi oluşturulan çocukların hakları ile ilgili inceleme velayet hakkı kapsamı esas alınarak hazırlanmıştır. Konunun daha iyi anlaşılabilmesi için öncelikle sharenting kavramı ve nedenleri açıklanmıştır. Ardından sharenting eyleminin çocuklar üzerindeki olumsuz etkileri incelenmiştir. Çalışmada anne ve babaların, çocuklarının özel hayatlarını sosyal medyada yayınlamalarının hukuki boyutu, ulusal ve uluslararası mevzuat göz önünde bulundurularak incelenmiştir.