bluuebunny/crossref_metadata_2025 huggingface dataset:
Iron-Nickel Alloy with Starfish-like Shape and Its Unique Magnetic Properties: Effect of Reaction Volume and Metal Concentration on the Synthesized Alloy
Authors: Nady Norhan , Salem Noha , Mohamed Marwa A. A. , Kandil Sherif H.
Published: November 2021

Iron-nickel alloy is an example of bimetallic nanostructures magnetic alloy, which receives intensive and significant attention in recent years due to its desirable superior ferromagnetic and mechanical characteristics. In this work, a unique starfish-like shape of an iron-nickel alloy with unique magnetic properties was presented using a simple, effective, high purity, and low-cost chemical reduction. There is no report on the synthesis of such novel shape without complex precursors and/or surfactants that increase production costs and introduce impurities, so far. The synthesis of five magnetic iron-nickel alloys with varying iron to nickel molar ratios (10–50% Fe) was undertaken by simultaneously reducing Fe(II) and Ni(II) solution using hydrazine hydrate as a reducing agent in strong alkaline media for 15 min at 95–98 °C. The effect of reaction volume and total metal concentration on the properties of the synthesized alloys was studied. Alloy morphology, chemical composition, crystal structure, thermal stability, and magnetic properties of synthesized iron-nickel alloys were characterized by means of SEM, TEM, EDX, XRD, DSC and VSM. ImageJ software was used to calculate the size of the synthesized alloys. A deviation from Vegard’s law was recorded for iron molar ration higher than 30%., in which superstructure phase of FeNi3 was formed and the presence of defects in it, as well as the dimensional effects of nanocrystals. The saturation magnetization (Ms), coercivity (Hc), retentivity (Mr), and squareness are strongly affected by the molar ratio of iron and nickel and reaction volume as well as the total metal concentration.
Challenges in Coopted Hydrophilic and Lipophilic Herbal Bioactives in the Same Nanostructured Carriers for Effective Bioavailability and Anti-Inflammatory Action
Authors: Iordache Teodora-Alexandra , Badea Nicoleta , Mihaila Mirela , Crisan Simona , Pop Anca Lucia , Lacatusu Ioana
Published: November 2021

There is ongoing research on various herbal bioactives and delivery systems which indicates that both lipid nanocarriers and herbal medicines will be fine tunned and integrated for future bio-medical applications. The current study was undertaken to systematically develop NLC-DSG-yam extract for the improved efficacy of herbal Diosgenin (DSG) in the management of anti-inflammatory disorders. NLCs were characterized regarding the mean size of the particles, morphological characteristics, physical stability in time, thermal behaviour, and entrapment efficiency of the herbal bioactive. Encapsulation efficiency and in vitro antioxidant activity measured the differences between the individual and dual co-loaded-NLC, the co-loaded one assuring a prolonged controlled release of DSG and a more emphasized ability of capturing short-life reactive oxygen species (ROS). NLCs safety properties were monitored following the in vitro MTS ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay) and RTCA (Real-Time Cell Analysis) assays. Concentrations less than 50 μg/mL showed no cytotoxic effects during in vitro cytotoxicity assays. Besides, the NLC-DSG-yam extract revealed a great anti-inflammatory effect, as the production of pro-inflammatory cytokines (TNF-alpha, IL-6) was significantly inhibited at 50 μg/mL NLC (e.g., 98.2% ± 1.07 inhibition of TNF-α, while for IL-6 the inhibition percentage was of 62% ± 1.07). Concluding, using appropriate lipid nanocarriers, the most desirable properties of herbal bioactives could be improved.
Configuration of Multifunctional Polyimide/Graphene/Fe3O4 Hybrid Aerogel-Based Phase-Change Composite Films for Electromagnetic and Infrared Bi-Stealth
Authors: Shi Tao , Zheng Zhiheng , Liu Huan , Wu Dezhen , Wang Xiaodong
Published: November 2021

Electromagnetic (EM) and infrared (IR) stealth play an important role in the development of military technology and the defense industry. This study focused on developing a new type of multifunctional composite film based on polyimide (PI)/graphene/Fe3O4 hybrid aerogel and polyethylene glycol (PEG) as a phase change material (PCM) for EM and IR bi-stealth applications. The composite films were successfully fabricated by constructing a series of PI-based hybrid aerogels containing different contents of graphene nanosheets and Fe3O4 nanoparticles through prepolymerizaton, film casting, freeze-drying, and thermal imidization, followed by loading molten PEG through vacuum impregnation. The construction of PI/graphene/Fe3O4 hybrid aerogel films provides a robust, flexible, and microwave-absorption-functionalized support material for PEG. The resultant multifunctional composite films not only exhibit high microwave absorption effectiveness across a broad frequency range, but also show a good ability to implement thermal management and temperature regulation under a high latent-heat capacity of over 158 J/g. Most of all, the multifunctional composite films present a wideband absorption capability at 7.0–16.5 GHz and a minimum reflection loss of −38.5 dB. This results in excellent EM and IR bi-stealth performance through the effective wideband microwave absorption of graphene/Fe3O4 component and the thermal buffer of PEG. This study offers a new strategy for the design and development of high-performance and lightweight EM–IR bi-stealth materials to meet the requirement of stealth and camouflage applications in military equipment and defense engineering.
Modified WCRF/AICR Score and All-Cause, Digestive System, Cardiovascular, Cancer and Other-Cause-Related Mortality: A Competing Risk Analysis of Two Cohort Studies Conducted in Southern Italy
Authors: Mirizzi Antonella , Aballay Laura R. , Misciagna Giovanni , Caruso Maria G. , Bonfiglio Caterina , Sorino Paolo , Bianco Antonella , Campanella Angelo , Franco Isabella , Curci Ritanna , Procino Filippo , Cisternino Anna M. , Notarnicola Maria , D’Aprile Pierina F. , Osella Alberto R.
Published: November 2021

Background: In real life, nutrition goes beyond purely biological domains. Primary prevention is the most efficient approach for reducing the risk of mortality. We aimed to study the association of lifestyle, as measured by a modified World Cancer Research Fund/American Institute for Cancer Research (mWCRF/AICR) scoring system with all-cause, digestive system disease-related (DSD-related), cardiovascular disease-related (CVD-related), cancer–related and other cause-related mortality using data from two population-based cohort studies conducted in Southern Italy. Methods: A random sample of 5271 subjects aged 18 years or older was enrolled in 2005–2006 and followed up until 2020. Usual food intakes were estimated using a validated dietary questionnaire. Competing risks survival models were applied. Results: High adherence to the mWCRF/AICR score was found to be statistically significant and negatively associated with all-cause mortality (HR 0.56, 95%CI 0.39; 0.82), DSD-related mortality (SHR 0.38, 95%CI 0.15; 0.97) and cancer-related mortality (SHR 0.43, 95%CI 0.19; 0.97) in the male sub-cohort and other-cause mortality (SHR 0.43, 95%CI 0.21; 0.88) only in the female group. Conclusions: This mWCRF/AICR score can be seen as a simple, easy tool for use in clinical practice to evaluate both qualitative and quantitative aspects of the diet.
Energy, Sodium, Sugar and Saturated Fat Content of New Zealand Fast-Food Products and Meal Combos in 2020
Authors: Mackay Sally , Gontijo de Castro Teresa , Young Leanne , Shaw Grace , Ni Mhurchu Cliona , Eyles Helen
Published: November 2021

This study aimed to benchmark the healthiness of the New Zealand (NZ) fast-food supply in 2020. There are currently no actions or policies in NZ regarding the composition, serving size and labeling of fast food. Data on serving size and nutrient content of products was collected from company websites and in-store visits to 27 fast-food chains. For each fast-food category and type of combo meal, medians and interquartile ranges were calculated for serving size and energy, sodium, total sugar, and saturated fat per serving. Nutrient contents/serving were benchmarked against the United Kingdom (UK) soft drinks levy sugar thresholds and targets for salt for away from home foods, the NZ daily intake guidelines for energy, sodium, and saturated fat, and the World Health Organization (WHO) recommendation for free sugars. Analyses were conducted for the 30.3% (n = 1772) of products with available nutrition information and for 176 meal combos. Most (n = 67; 91.8%) sugar-sweetened drinks would qualify for a UK soft drink industry levy and 47% (n = 1072) of products exceeded the relevant UK sodium target. Half of the meal combos provided at least 50.3% of the daily energy requirements and at least 88.6% of the maximum recommended intake of sodium. Fast-food products and combo meals in NZ contribute far more energy and negative nutrients to recommended daily intake targets than is optimal for good health. The NZ Government should set reformulation targets and serving size guidance to reduce the potential impact of fast- food consumption on the health of New Zealanders.
Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa
Authors: Maigler Frank , Ladel Simone , Flamm Johannes , Gänger Stella , Kurpiers Barbara , Kiderlen Stefanie , Völk Ronja , Hamp Carmen , Hartung Sunniva , Spiegel Sebastian , Soleimanizadeh Arghavan , Eberle Katharina , Hermann Rebecca , Krainer Lukas , Pitzer Claudia , Schindowski Katharina
Published: November 2021

Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents. Thus, the lack of a precise and region-specific application technique for mice is a major drawback. In this study, a previously developed catheter-based refined technique was validated against the conventional pipette-based method and used to specifically reach the olfactory or the respiratory nasal regions. This study successfully demonstrated region-specific administration at the olfactory mucosa resulting in over 20% of the administered fluorescein dose in the olfactory bulbs, and no peripheral bioactivity of insulin detemir and Fc-dependent uptake of two murine IgG1 (11C7 and P3X) along the olfactory pathway to cortex and hippocampus. An scFv of 11C7 showed hardly any uptake to the CNS. Elimination was dependent on the presence of the IgG’s antigen. In summary, it was successfully demonstrated that region-specific intranasal administration via the olfactory region resulted in improved brain targeting and reduced peripheral targeting in mice. The data are discussed with regard to their clinical potential.
Susceptibility of Dental Caries Microcosm Biofilms to Photodynamic Therapy Mediated by Fotoenticine
Authors: Garcia Maíra Terra , Ward Rafael Araújo da Costa , Gonçalves Nathália Maria Ferreira , Pedroso Lara Luise Castro , Neto José Vieira da Silva , Strixino Juliana Ferreira , Junqueira Juliana Campos
Published: November 2021

Photodynamic therapy (PDT) mediated by Fotoenticine® (FTC), a new photosensitizer derived from chlorin e-6, has shown in vitro inhibitory activity against the cariogenic bacterium Streptococcus mutans. However, its antimicrobial effects must be investigated on biofilm models that represent the microbial complexity of caries. Thus, we evaluated the efficacy of FTC-mediated PDT on microcosm biofilms of dental caries. Decayed dentin samples were collected from different patients to form in vitro biofilms. Biofilms were treated with FTC associated with LED irradiation and analyzed by counting the colony forming units (log10 CFU) in selective and non-selective culture media. Furthermore, the biofilm structure and acid production by microorganisms were analyzed using microscopic and spectrophotometric analysis, respectively. The biofilms from different patients showed variations in microbial composition, being formed by streptococci, lactobacilli and yeasts. Altogether, PDT decreased up to 3.7 log10 CFU of total microorganisms, 2.8 log10 CFU of streptococci, 3.2 log10 CFU of lactobacilli and 3.2 log10 CFU of yeasts, and reached eradication of mutans streptococci. PDT was also capable of disaggregating the biofilms and reducing acid concentration in 1.1 to 1.9 mmol lactate/L. It was concluded that FTC was effective in PDT against the heterogeneous biofilms of dental caries.
Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions
Authors: Jelić Dijana , Papović Snežana , Vraneš Milan , Gadžurić Slobodan , Berto Silvia , Alladio Eugenio , Gajić Dragana , Janković Bojan
Published: November 2021

Ambroxol hydrochloride (AMB), used as a broncho secretolytic and an expectorant drug, is a semi-synthetic derivative of vasicine obtained from the Indian shrub Adhatoda vasica. It is a metabolic product of bromhexine. The paper provides comprehensive and detailed research on ambroxol hydrochloride, gives information on thermal stability, the mechanism of AMB degradation, and data of practical interest for optimization of formulation that contains AMB as an active compound. Investigation on pure AMB and in commercial formulation Flavamed® tablet (FT), which contains AMB as an active compound, was performed systematically using thermal and spectroscopic methods, along with a sophisticated and practical statistical approach. AMB proved to be a heat-stable and humidity-sensitive drug. For its successful formulation, special attention should be addressed to excipients since it was found that polyvinyl pyrrolidone and Mg stearate affect the thermal stability of AMB. At the same time, lactose monohydrate contributes to faster degradation of AMB and change in decomposition mechanism. It was found that the n-th order kinetic model mechanistically best describes the decomposition process of pure AMB and in Flavamed® tablets.
Annatto Oil Loaded Nanostructured Lipid Carriers: A Potential New Treatment for Cutaneous Leishmaniasis
Authors: Ferreira Marianna Araújo , de Almeida Júnior Renato Ferreira , Onofre Thiago Souza , Casadei Bruna Renata , Farias Kleber Juvenal Silva , Severino Patricia , de Oliveira Franco Camilo Flamarion , Raffin Fernanda Nervo , de Lima e Moura Túlio Flávio Accioly , de Melo Barbosa Raquel
Published: November 2021

Annatto (Bixa orellana L.) is extensively used as food pigment worldwide. Recently, several studies have found it to have healing and antioxidant properties, as well as effective action against leishmaniasis. Therefore, the purpose of this study was to incorporate the oil obtained from annatto seeds into a nanostructured lipid carrier (NLC) and evaluate its physicochemical properties and biological activity against Leishmania major. Nanoparticles were prepared by the fusion-emulsification and ultrasonication method, with the components Synperonic™ PE (PL) as the surfactant, cetyl palmitate (CP) or myristyl myristate (MM) as solid lipids, annatto oil (AO) (2% and 4%, w/w) as liquid lipid and active ingredient, and ultra-pure water. Physicochemical and biological characterizations were carried out to describe the NLCs, including particle size, polydispersity index (PDI), and zeta potential (ZP) by dynamic light scattering (DLS), encapsulation efficiency (EE%), thermal behavior, X-ray diffraction (XRD), transmission electron microscopy (TEM), Electron Paramagnetic Resonance (EPR), cytotoxicity on BALB/c 3T3 fibroblasts and immortalized human keratinocyte cells, and anti-leishmaniasis activity in vitro. Nanoparticles presented an average diameter of ~200 nm (confirmed by TEM results), a PDI of less than 0.30, ZP between −12.6 and −31.2 mV, and more than 50% of AO encapsulated in NLCs. Thermal analyses demonstrated that the systems were stable at high temperatures with a decrease in crystalline structure due to the presence of AOs (confirmed by XRD). In vitro, the anti-leishmania test displayed good activity in encapsulating AO against L. major. The results indicate that the oily fraction of Bixa orellana L. in NLC systems should be evaluated as a potential therapeutic agent against leishmaniasis.
Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
Authors: Hung Yuan-Pin , Chen Yu-Fon , Tsai Pei-Jane , Huang I-Hsiu , Ko Wen-Chien , Jan Jeng-Shiung
Published: November 2021

Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.
Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy
Authors: Zhao Yijun , Ouyang Xumei , Peng Yongjun , Peng Shaojun
Published: November 2021

Gas therapy has received widespread attention from the medical community as an emerging and promising therapeutic approach to cancer treatment. Among all gas molecules, nitric oxide (NO) was the first one to be applied in the biomedical field for its intriguing properties and unique anti-tumor mechanisms which have become a research hotspot in recent years. Despite the great progress of NO in cancer therapy, the non-specific distribution of NO in vivo and its side effects on normal tissue at high concentrations have impaired its clinical application. Therefore, it is important to develop facile NO-based nanomedicines to achieve the on-demand release of NO in tumor tissue while avoiding the leakage of NO in normal tissue, which could enhance therapeutic efficacy and reduce side effects at the same time. In recent years, numerous studies have reported the design and development of NO-based nanomedicines which were triggered by exogenous stimulus (light, ultrasound, X-ray) or tumor endogenous signals (glutathione, weak acid, glucose). In this review, we summarized the design principles and release behaviors of NO-based nanomedicines upon various stimuli and their applications in synergistic cancer therapy. We also discuss the anti-tumor mechanisms of NO-based nanomedicines in vivo for enhanced cancer therapy. Moreover, we discuss the existing challenges and further perspectives in this field in the aim of furthering its development.
Simulated Study of High-Sensitivity Gas Sensor with a Metal-PhC Nanocavity via Tamm Plasmon Polaritons
Authors: Li Liang , Hao Haoyue
Published: November 2021

An optical configuration was designed and simulated with a metal-photonic crystal (PhC) nanocavity, which had high sensitivity on gas detection. The simulated results shows that this configuration can generate a strong photonic localization through exciting Tamm plasmon polaritons. The strong photonic localization highly increases the sensitivity of gas detection. Furthermore, this configuration can be tuned to sense gases at different conditions through an adjustment of the detection light wavelength, the period number of photonic crystal and the thickness of the gas cavity. The sensing routes to pressure variations of air were revealed. The simulation results showed that the detection precision of the proposed device for gas pressure could reach 0.0004 atm.
Quantitative Phase Imaging to Study the Effect of Sodium Dodecyl Surfactant on Adherent L929 Fibroblasts on Tissue Culture Plates
Authors: Sitthisang Sonthikan , Boonruangkan Jeeranan , Leong Meng Fatt , Chian Kerm Sin , Kim Young-Jin
Published: November 2021

Decellularization is the process of removing cellular components from native tissues or organs to obtain an acellular, collagenous scaffold for use in tissue engineering and organ regeneration. Surfactants are widely used to produce acellular scaffolds for clinical applications. However, cell–surfactants interactions have not been studied in depth. Cell-surfactant interaction was studied in a time-lapsed manner using sodium dodecyl sulfate (SDS) solution (surfactant) on adherent L929 fibroblasts as a test solution, phosphate-buffered saline (PBS) solution as control solution (isotonic), and deionized water as positive test solution (hypotonic), respectively. The QPI results show changes in the relative height and cross-sectional area of the cells, with various test solutions and exposure times. In particular, it was observed that the removal of the cell with SDS involved the disruption of the cellular membrane and detachment of the cell contents from the adhering surface. This study demonstrated the feasibility of using the QPI technique to understand the decellularization process.
Differential Physiological Responses to Salt Stress between Salt-Sensitive and Salt-Tolerant japonica Rice Cultivars at the Post-Germination and Seedling Stages
Authors: Ye Shenghai , Huang Zhibo , Zhao Guibin , Zhai Rongrong , Ye Jing , Wu Mingming , Yu Faming , Zhu Guofu , Zhang Xiaoming
Published: November 2021

Soil salinity is a key source of abiotic stress in the cultivation of rice. In this study, two currently cultivated japonica rice species—Zhegeng 78 (salt-tolerant) and Zhegeng 99 (salt-sensitive)—with similar backgrounds were identified and used to investigate their differential responses to salt stress at the post-germination and seedling stages. Quantitative RT-PCR analysis demonstrated that the expression of OsSOS1, OsHAK1, and OsHAK5 at the post-germination stage, and the expression of OsHKT1,1, OsHTK2,1, and OsHAK1 at the seedling stage, were significantly higher in the salt-tolerant Zhegeng 78 compared with those of the salt-sensitive Zhegeng 99 under salt stress. The significantly lower Na+ net uptake rate at the post-germination and higher K+ net uptake rates at the post-germination and seedling stages were observed in the salt-tolerant Zhegeng 78 compared with those of the salt-sensitive Zhegeng 99 under salt stress. Significantly higher activity of peroxidase (POD) and the lower hydrogen peroxide (H2O2) accumulation were observed in the salt-tolerant Zhegeng 78 compared with those of salt-sensitive Zhegeng 99 under salt stress at the seeding stage. The salt-tolerant Zhegeng 78 might be valuable in future cultivation in salinity soils.
Chemical Modification of Glycoproteins’ Carbohydrate Moiety as a General Strategy for the Synthesis of Efficient Biocatalysts by Biomimetic Mineralization: The Case of Glucose Oxidase
Authors: Stanišić Marija D. , Popović Kokar Nikolina , Ristić Predrag , Balaž Ana Marija , Senćanski Milan , Ognjanović Miloš , Đokić Veljko R. , Prodanović Radivoje , Todorović Tamara R.
Published: November 2021

Zeolitic imidazolate framework-8 (ZIF-8) is widely used as a protective coating to encapsulate proteins via biomimetic mineralization. The formation of nucleation centers and further biocomposite crystal growth is entirely governed by the pure electrostatic interactions between the protein’s surface and the positively charged Zn(II) metal ions. It was previously shown that enhancing these electrostatic interactions by a chemical modification of surface amino acid residues can lead to a rapid biocomposite crystal formation. However, a chemical modification of carbohydrate components by periodate oxidation for glycoproteins can serve as an alternative strategy. In the present study, an industrially important enzyme glucose oxidase (GOx) was selected as a model system. Periodate oxidation of GOx by 2.5 mM sodium periodate increased negative charge on the enzyme molecule, from −10.2 to −36.9 mV, as shown by zeta potential measurements and native PAGE electrophoresis. Biomineralization experiments with oxidized GOx resulted in higher specific activity, effectiveness factor, and higher thermostability of the ZIF-8 biocomposites. Periodate oxidation of carbohydrate components for glycoproteins can serve as a facile and general method for facilitating the biomimetic mineralization of other industrially relevant glycoproteins.
Pyrrole Plasma Polymer-Coated Electrospun Scaffolds for Neural Tissue Engineering
Authors: Osorio-Londoño Diana María , Godínez-Fernández José Rafael , Acosta-García Ma. Cristina , Morales-Corona Juan , Olayo-González Roberto , Morales-Guadarrama Axayácatl
Published: November 2021

Promising strategies for neural tissue engineering are based on the use of three-dimensional substrates for cell anchorage and tissue development. In this work, fibrillar scaffolds composed of electrospun randomly- and aligned-oriented fibers coated with plasma synthesized pyrrole polymer, doped and undoped with iodine, were fabricated and characterized. Infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction analysis revealed the functional groups and molecular integration of each scaffold, as well as the effect of plasma polymer synthesis on crystallinity. Scanning microscopy imaging demonstrated the porous fibrillar micrometric structure of the scaffolds, which afforded adhesion, infiltration, and survival for the neural cells. Orientation analysis of electron microscope images confirmed the elongation of neurite-like cell structures elicited by undoped plasma pyrrole polymer-coated aligned scaffolds, without any biochemical stimuli. The MTT colorimetric assay validated the biocompatibility of the fabricated composite materials, and further evidenced plasma pyrrole polymer-coated aligned scaffolds as permissive substrates for the support of neural cells. These results suggest plasma synthesized pyrrole polymer-coated aligned scaffolds are promising materials for tissue engineering applications.
Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes
Authors: Valencia-Llano Carlos Humberto , Solano Moisés A. , Grande-Tovar Carlos David
Published: November 2021

New technologies based on nanocomposites of biopolymers and nanoparticles inspired by the nature of bone structure have accelerated their application in regenerative medicine, thanks to the introduction of reinforcing properties. Our research incorporated chitosan (CS) covalently crosslinked with glutaraldehyde (GLA) beads with graphene oxide (GO) nanosheets, titanium dioxide nanoparticles (TiO2), and blackberry processing waste extract (BBE) and evaluated them as partial bone substitutes. Skullbone defects in biomodels filled with the scaffolds showed evidence through light microscopy, scanning electron microscopy, histological studies, soft tissue development with hair recovery, and absence of necrotic areas or aggressive infectious response of the immune system after 90 days of implantation. More interestingly, newly formed bone was evidenced by elemental analysis and Masson trichromacy analysis, which demonstrated a possible osteoinductive effect from the beads using the critical size defect experimental design in the biomodels. The results of this research are auspicious for the development of bone substitutes and evidence that the technologies for tissue regeneration, including chitosan nanocomposites, are beneficial for the adhesion and proliferation of bone cells.
3D-Printed Porous Magnetic Carbon Materials Derived from Metal–Organic Frameworks
Authors: Cherevko Anton I. , Nikovskiy Igor A. , Nelyubina Yulia V. , Skupov Kirill M. , Efimov Nikolay N. , Novikov Valentin V.
Published: November 2021

Here we report new porous carbon materials obtained by 3D printing from photopolymer compositions with zinc- and nickel-based metal–organic frameworks, ZIF-8 and Ni-BTC, followed by high-temperature pyrolysis. The pyrolyzed materials that retain the shapes of complex objects contain pores, which were produced by boiling zinc and magnetic nickel particles. The two thus provided functionalities—large specific surface area and ferromagnetism—that pave the way towards creating heterogenous catalysts that can be easily removed from reaction mixtures in industrial catalytic processes.
Mechanical Properties and Energy Absorption Characteristics of Additively Manufactured Lightweight Novel Re-Entrant Plate-Based Lattice Structures
Authors: Al Hassanieh Sultan , Alhantoobi Ahmed , Khan Kamran A. , Khan Muhammad A.
Published: November 2021

In this work, three novel re-entrant plate lattice structures (LSs) have been designed by transforming conventional truss-based lattices into hybrid-plate based lattices, namely, flat-plate modified auxetic (FPMA), vintile (FPV), and tesseract (FPT). Additive manufacturing based on stereolithography (SLA) technology was utilized to fabricate the tensile, compressive, and LS specimens with different relative densities (ρ). The base material’s mechanical properties obtained through mechanical testing were used in a finite element-based numerical homogenization analysis to study the elastic anisotropy of the LSs. Both the FPV and FPMA showed anisotropic behavior; however, the FPT showed cubic symmetry. The universal anisotropic index was found highest for FPV and lowest for FPMA, and it followed the power-law dependence of ρ. The quasi-static compressive response of the LSs was investigated. The Gibson–Ashby power law (≈ρn) analysis revealed that the FPMA’s Young’s modulus was the highest with a mixed bending–stretching behavior (≈ρ1.30), the FPV showed a bending-dominated behavior (≈ρ3.59), and the FPT showed a stretching-dominated behavior (≈ρ1.15). Excellent mechanical properties along with superior energy absorption capabilities were observed, with the FPT showing a specific energy absorption of 4.5 J/g, surpassing most reported lattices while having a far lower density.
Determination of Dental Adhesive Composition throughout Solvent Drying and Polymerization Using ATR–FTIR Spectroscopy
Authors: Almusa Arwa , Delgado António H. S. , Ashley Paul , Young Anne M.
Published: November 2021

The of this study aim was to develop a rapid method to determine the chemical composition, solvent evaporation rates, and polymerization kinetics of dental adhesives. Single-component, acetone-containing adhesives One-Step (OS; Bisco, Anaheim, CA, USA), Optibond Universal (OU; Kerr, Brea, CA, USA), and G-Bond (GB; GC, Tokyo, Japan) were studied. Filler levels were determined gravimetrically. Monomers and solvents were quantified by comparing their pure Attenuated Total Reflectance-Fourier Transform Infra-Red (ATR–FTIR) spectra, summed in different ratios, with those of the adhesives. Spectral changes at 37 °C, throughout passive evaporation for 5 min, then polymerisation initiated by 20 s, and blue light emitting diode (LED) (600 mW/cm2) exposure (n = 3) were determined. Evaporation and polymerisation extent versus time and final changes were calculated using acetone (1360 cm−1) and methacrylate (1320 cm−1) peaks. OS, OU, and GB filler contents were 0, 9.6, and 5.3%. FTIR suggested OS and OU were Bis-GMA based, GB was urethane dimethacrylate (UDMA) based, and that each had a different diluent and acidic monomers and possible UDMA/acetone interactions. Furthermore, initial acetone percentages were all 40–50%. After 5 min drying, they were 0% for OS and OU but 10% for GB. Whilst OS had no water, that in OU declined from 18 to 10% and in GB from 25 to 20% upon drying. Evaporation extents were 50% of final levels at 23, 25, and 113 s for OS, OU, and GB, respectively. Polymerisation extents were all 50 and 80% of final levels before 10 and at 20 s of light exposure, respectively. Final monomer polymerisation levels were 68, 69, and 88% for OS, OU, and GB, respectively. An appreciation of initial and final adhesive chemistry is important for understanding the properties. The rates of evaporation and polymerisation provide indications of relative required drying and light cure times. UDMA/acetone interactions might explain the considerably greater drying time of GB.
The Effect of Chitosan Type on Biological and Physicochemical Properties of Films with Propolis Extract
Authors: Stanicka Karolina , Dobrucka Renata , Woźniak Magdalena , Sip Anna , Majka Jerzy , Kozak Wojciech , Ratajczak Izabela
Published: November 2021

The aim of the research was to determine the influence of chitosan type and propolis extract concentration on biological and physicochemical properties of chitosan-propolis films in terms of their applicability in food packaging. The films were prepared using three types of chitosan: from crab shells, medium and high molecular weight and propolis concentration in the range of 0.75–5.0%. The prepared polysaccharide films were tested for antimicrobial properties, oxygen transmission rate (OTR) and water vapor transmission rate (WVTR). Moreover, sorption tests and structural analysis were carried out. Microbiological tests indicated the best antimicrobial activity for the film consisting of high molecular weight chitosan and 5.0% propolis extract. Both the type of chitosan and propolis concentration affected transmission parameters—OTR and WVTR. The best barrier properties were recorded for the film composed of high molecular weight chitosan and 5.0% propolis extract. The results of sorption experiments showed a slight influence of chitosan type and a significant effect of propolis extract concentration on equilibrium moisture content of tested films. Moreover, propolis extract concentration affected monolayer water capacity (Mm) estimated using the Guggenheim, Anderson and de Boer (GAB) sorption model. The obtained results indicate that chitosan films with an addition of propolis extract are promising materials for food packaging applications, including food containing probiotic microorganisms.
Controlled Degradation of Commercial Resin for Meltblown Nonwoven Fabric Sheet Production
Authors: Sasai Yuya , Iizuka Yoshio , Osada Kaho , Taki Kentaro
Published: November 2021

Manufacturing meltblown nonwoven fabrics requires special grades of resin with very low viscosity, which are not dealt with so much on market and cost quite high compared to the standard grades. We propose a high-shear rate processing method that can quickly and easily produce such low-viscosity resin from the commercial one without using organic peroxides. In this method, we apply high-shear stress to molten resin by using a high-shear extruder, which is a single screw extruder with high screw rotation speed, and the resin is thermally decomposed of its shear-induced heat which is quickly generated. We found that polypropylene with a value of melt flow rate over a thousand, which was required for the meltblown process, was produced from the standard grade with the high-shear extruder at the screw rotation speed of 3600 min−1 and the barrel temperature over 300 ∘C. Using the degradated polypropylene, a meltblown nonwoven fabric sheet was successfully fabricated. We also developed a numerical simulator of the high-shear extruder which can handle a wide range of the screw rotation speed and barrel temperature by the Nusselt number modulated with the operational conditions. The experimental values of the zero-shear viscosity and temperature at the exit of the extruder agreed well with the simulation results. Our high-shear rate processing method will enable us to quickly and easily produce various meltblown nonwoven fabric sheets at low costs.
Effects of Automotive Test Parameters on Dry Friction Fiber-Reinforced Clutch Facing Surface Microgeometry and Wear
Authors: Biczó Roland , Kalácska Gábor , Mankovits Tamás
Published: November 2021

Wear and surface microgeometry aspects of fiber-reinforced hybrid composite dry friction clutch facings are revealed in a novel way: after different, real life automotive tests during their lifetime. This study examines and reveals the tribological response of friction material surfaces to real life application conditions with two different facing diameters and in two directions. Along the increasing activation energy scale, wear values increased according to two different trends, sorting tests into two main groups, namely ‘clutch killer’ and ‘moderate’. Wear results also highlighted the influence of mileage and test conditions, with clutch killer tests also creating considerable wear-more than 0.1 mm-at inner diameters: 1% higher wear was generated by 90% higher mileage; another 1% increment could be caused by insufficient cooling time or test bench-specific conditions. Surface roughness values trends varied accordingly with exceptions revealing effects of facing size, friction diameter and directions and test conditions: small (S) facings produced significantly decreased Rmax roughness, while large (L) and medium (M) size facings had increased roughness values; Rmax results showed the highest deviations among roughness values in radial direction; tests run with trailer and among city conditions resulted in more than 2% thickness loss and a 40–50% roughness decrease.
Phase Transitions of Polarised PVDF Films in a Standard Curing Process for Composites
Authors: Vasic Nils , Steinmetz Julian , Görke Marion , Sinapius Michael , Hühne Christian , Garnweitner Georg
Published: November 2021

The article reports on the influence of annealing PVDF in an autoclave process on the PVDF phase composition. DSC, FTIR and XRD measurements serve to observe the phase changes in an already stretched, polarised and β-phase rich film. Annealing was conducted between 90 and 185 ∘C to cover a broad range of curing processes in an autoclave. The β-phase is found to be stable up to near the melting range at 170 ∘C. At 175 ∘C, the non-piezoelectric α-phase dominates and the piezoelectric γ- and γ′-phases appear. The γ-phase grows at elevated temperatures and replaces the β-phase. This observation stresses the importance of developing new methods to reactivate the polarisation after annealing, in particular for the integration of PVDF as a sensor in laminated structures, such as CFRP.
Development Strategy of Endodontic Filling Materials Based on Engineering and Medical Approaches
Authors: Dobrzański Leszek A. , Dobrzańska Joanna , Dobrzański Lech B. , Dobrzańska-Danikiewicz Anna D. , Gołombek Klaudiusz
Published: November 2021

This article is a literature review aimed at presenting the general state of knowledge in manufacturing engineering and materials engineering to develop engineering materials applied for endodontic treatment as filling materials. Particular attention was paid to theoretical analyses concerning the selection of methods for developing and obturating root canals and discussing the results of experimental studies available in the literature. These activities aimed to compare the importance of the most commonly used endodontic filling materials based on gutta-percha or polymeric polyester materials, commonly known as resilon, respectively. The motivation to take up this complex, multi-faceted topic in this paper is the extent of caries, periodontal disease, and other oral diseases in 3 to 5 billion people, often affecting toothlessness and contributing to an increase in the index of disability-adjusted life years (number). Endodontics is an important element of the authors’ concept of Dentistry Sustainable Development (DSD) > 2020. The principles of qualifying patients for endodontic treatment are discussed. The introduction of rotary tools, especially manufactured from Nitinol alloy, to develop root canals and the latest thermohydraulic and condensation techniques for obturation guarantee progress in endodontics. The “Digital Twins” methodology was used, rooted in the idea of Industry 4.0 and the resulting idea of Dentistry 4.0, as well as knowledge management methods, to perform experimental research in virtual space, concerning methods of developing and obturating the root canal and assessing the tightness of fillings. Microscopic visualization methods were also used. Significant factors determining the effectiveness of endodontic obturation are the selection of the filling material and the appropriate obturation method. The generalized dendrological matrix of endodontic filling materials considers the criteria of mechanical strength influencing the potential root fracture and the quality of root canal filling. The results of the SWOT point analysis (strengths and weaknesses, opportunities, threats) were also compared. For both filling materials, the weaknesses are much less than the strengths, while the threats are slightly less than the opportunities for the gutta-percha-based material, while for resilon the opportunities are much smaller than the threats. It requires the application of an appropriate development strategy, i.e., MAXI-MAXI in the case of a filling material based on gutta-percha and MAXI-MINI in the case of resilon. Therefore, the analysis of these experimental data does not indicate the real competitiveness of resilon for the gutta-percha-based material. This material deservedly maintains its strong position as the “Gold Standard of Endodontics”.
Post-Secular Identity? Developing a New Approach to Religion in International Relations and IR Studies
Authors: Kulska Joanna , Solarz Anna M.
Published: November 2021

In spite of the increasing presence of religion in international relations with various publications observing this presence and numerous authorities calling for the inclusion of religion into mainstream research, there is no universal consent to recognize religion’s role in IR. In our opinion, the only way to reconcile IR with the international reality in which religion has been and will remain present in the foreseeable future is for the researchers themselves to construct—especially those oriented towards broad, non-Western perspective—a new face of the discipline, the face which in this article we call the post-secular identity of IR study. Assuming that identity is first and foremost a form of knowledge that tells us how we can define ourselves against the background of the surrounding world, our purpose is to look at the post-secular identity from two different perspectives which are analyzed in the two distinctive parts of the paper. On one hand, post-secular identity would mean the socio-political but also cultural phenomenon of the “knowledge of the self” expressed in the form of ideas, interests and goals of various state and nonstate actors, both religious and secular ones, that are more or less conditioned by religious determinants. We propose looking at them through the prism of a new kind of “partnership” emerging as a result of post-secular thinking in the area of IR. On the other hand, we want to look at post-secular identity as the badly required transformation within the area of IR study that, as we claim, needs to construct more inclusive views of IR scholars adopting a deliberative and pluralistic approach to the reality they examine based on widening their epistemological and hermeneutical horizons. This redefinition would be framed by recognizing religion as rational and adopting the view that the limits of the scientific methods do not coincide with the boundaries of rationality. We also adopt the view that along with the cognitive expansion of the universe, the concept of transcendence has been broadened.
Life to the Full: Sustaining the Catholic Curriculum
Authors: Fincham David
Published: November 2021

Catholic schools. has articulated There are concerns that the curriculum of Catholic schools has been increasingly dominated by pressures to conform to a programme of education legitimised by an intrusive secular state and designated as a ‘national curriculum’. Accordingly, the curriculum of Catholic maintained schools is regulated within a standardised framework that is directed by government. Contentiously, it has been asserted that, as a result, the curriculum in Catholic schools in England has effectively been ‘de-Catholicised’. This claim has been contested. For example, it is maintained that the matter is more nuanced than this and the situation cannot be interpreted in such an unequivocal way. However, it might well be asked: what should a Catholic curriculum look like? In the face of this question, leaders in Catholic schools are encouraged to consider renewing and restoring a distinctive curriculum by permeating it systematically with the principles of Catholic social teaching. Ultimately, the writer argues, the curriculum of Catholic schools should provide students with an understanding of the teachings of Jesus Christ.
Rethinking the Proportional Design Principles of Timber-Framed Buddhist Buildings in the Goryeo Era
Authors: Cha Ju-Hwan , Kim Young-Jae
Published: November 2021

This study examines how the wooden architecture of the Goryeo Dynasty in Korea evolved in an original way while incorporating Chinese architectural principles. For the Goryeo Era’s timber-framed buildings, eave purlin height was determined according to √2H times the eave column height (H), while the eave column height influenced the proportional location of each purlin, determined by the √2H times decrease rate in the cross-section. Thus, eave column height was proportionately connected to a geometric sequence with a common ratio of √2H. This technical approach, achieved using an L-square ruler and a drawing compass, contributed to determining eave purlin and ridge post placement, bracket system height, and outermost bay width. This study notes that the practical works were consistently preserved in East Asian Buddhist architecture, in that a universal rule of proportion was applied to buildings constructed during the Tang–Song and the Goryeo Dynasties, surmounting differences in local construction methods. These design principles were a vestige of socio-cultural exchange on the East Asian continent and a minimal step toward the establishment of structurally safe framed buildings.
Gandhi’s Militant Nonviolence in the Light of Girard’s Mimetic Anthropology
Authors: Palaver Wolfgang
Published: November 2021

Nuclear rivalry, as well as terrorism and the war against terror, exemplify the dangerous escalation of violence that is threatening our world. Gandhi’s militant nonviolence offers a possible alternative that avoids a complacent indifference toward injustice as well as the imitation of violence that leads to its escalation. The French-American cultural anthropologist René Girard discovered mimetic rivalries as one of the main roots of human conflicts, and also highlighted the contagious nature of violence. This article shows that Gandhi shares these basic insights of Girard’s anthropology, which increases the plausibility of his plea for nonviolence. Reading Gandhi with Girard also complements Girard’s mimetic theory by offering an active practice of nonviolence as a response to violent threats, and by broadening the scope of its religious outreach. Gandhi’s reading of the Sermon on Mount not only renounces violence and retaliation like Girard but also underlines the need to actively break with evil. Both Gandhi and Girard also address the religious preconditions of nonviolent action by underlining the need to prefer godly over worldly pursuits, and to overcome the fear of death by God’s grace. This congruence shows that Girard’s anthropology is valid beyond its usual affinity with Judaism and Christianity.