bluuebunny/crossref_metadata_2025 huggingface dataset:
Data Quality and Trust: Review of Challenges and Opportunities for Data Sharing in IoT
Authors: Byabazaire John , O’Hare Gregory , Delaney Declan
Published: December 2020

Existing research recognizes the critical role of quality data in the current big-data and Internet of Things (IoT) era. Quality data has a direct impact on model results and hence business decisions. The growth in the number of IoT-connected devices makes it hard to access data quality using traditional assessments methods. This is exacerbated by the need to share data across different IoT domains as it increases the heterogeneity of the data. Data-shared IoT defines a new perspective of IoT applications which benefit from sharing data among different domains of IoT to create new use-case applications. For example, sharing data between smart transport and smart industry can lead to other use-case applications such as intelligent logistics management and warehouse management. The benefits of such applications, however, can only be achieved if the shared data is of acceptable quality. There are three main practices in data quality (DQ) determination approaches that are restricting their effective use in data-shared platforms: (1) most DQ techniques validate test data against a known quantity considered to be a reference; a gold reference. (2) narrow sets of static metrics are used to describe the quality. Each consumer uses these metrics in similar ways. (3) data quality is evaluated in isolated stages throughout the processing pipeline. Data-shared IoT presents unique challenges; (1) each application and use-case in shared IoT has a unique description of data quality and requires a different set of metrics. This leads to an extensive list of DQ dimensions which are difficult to implement in real-world applications. (2) most data in IoT scenarios does not have a gold reference. (3) factors endangering DQ in shared IoT exist throughout the entire big-data model from data collection to data visualization, and data use. This paper aims to describe data-shared IoT and shared data pools while highlighting the importance of sharing quality data across various domains. The article examines how we can use trust as a measure of quality in data-shared IoT. We conclude that researchers can combine such trust-based techniques with blockchain for secure end-to-end data quality assessment.
Analysis of Factors Influencing Food Nutritional Labels Use in Nanjing, China
Authors: Zhang Jing , Zhai Liangliang , Osewe Maurice , Liu Aijun
Published: December 2020

A correct use of food nutrition la bels benefits consumers in pursuing balanced diets. As a result, we conducted interviews in Nanjing, China and randomly sampled 427 respondents. Further, we used both descriptive statistics and binary logistic regression to assess their perception of food nutrition label use. The results indicated that the current situation is not ideal in Nanjing. Only 7.26% of respondents use labeling consistently. Data on purchasing experience, comprehension, nutritional value, work sector, chronic disease, diet awareness, nutritional knowledge, and age were statistically significant. Conversely, taste and primary shopper categories negatively influenced food nutrition label use. In light of the above results, we propose policy recommendations to promote consumers’ use of food nutrition labels. These are also beneficial in improving diet and relieving chronic diseases.
High Glucosinolate Content in Rocket Leaves (Diplotaxis tenuifolia and Eruca sativa) after Multiple Harvests Is Associated with Increased Bitterness, Pungency, and Reduced Consumer Liking
Authors: Bell Luke , Lignou Stella , Wagstaff Carol
Published: December 2020

Rocket (Diplotaxis tenuifolia and Eruca sativa) leaves delivered to the UK market are variable in appearance, taste, and flavour over the growing season. This study presents sensory and consumer analyses of rocket produce delivered to the UK over the course of one year, and evaluated the contribution of environmental and cultivation factors upon quality traits and phytochemicals called glucosinolates (GSLs). GSL abundance was positively correlated with higher average growth temperatures during the crop cycle, and perceptions of pepperiness, bitterness, and hotness. This in turn was associated with reduced liking, and corresponded to low consumer acceptance. Conversely, leaves with greater sugar content were perceived as more sweet, and had a higher correlation with consumer acceptance of the test panel. First cut leaves of rocket were favoured more by consumers, with multiple leaf cuts associated with low acceptance and higher glucosinolate concentrations. Our data suggest that the practice of harvesting rocket crops multiple times reduces consumer acceptability due to increases in GSLs, and the associated bitter, hot, and peppery perceptions some of their hydrolysis products produce. This may have significant implications for cultivation practices during seasonal transitions, where leaves typically receive multiple harvests and longer growth cycles.
Proximate Composition, Cyanide Content, and Carotenoid Retention after Boiling of Provitamin A-Rich Cassava Grown in Ghana
Authors: Boakye Peprah Bright , Parkes Elizabeth Y. , Harrison Obed A. , van Biljon Angeline , Steiner-Asiedu Matilda , Labuschagne Maryke T.
Published: December 2020

Biofortified yellow-fleshed cassava is important in countries with high cassava consumption, to improve the vitamin A status of their populations. Yellow- and white-fleshed cassava were evaluated over three locations for proximate composition and cyanide content as well as retention of carotenoids after boiling. There was significant variation in the crude fiber, fat, protein and ash content of the genotypes. All but one of the yellow-fleshed cassava genotypes recorded higher protein values than the white-fleshed local genotypes across locations. The cyanide content of the genotypes varied between locations but was within the range of sweet cassava genotypes, but above the maximum acceptable recommended limit. Micronutrient retention is important in biofortified crops because a loss of micronutrients during processing and cooking reduces the nutritional value of biofortified foods. Total carotenoid content (TCC) ranged from 1.18–18.81 μg.g−1 and 1.01–13.36 μg.g−1 (fresh weight basis) for fresh and boiled cassava, respectively. All the yellow-fleshed cassava genotypes recorded higher TCC values in both the fresh and boiled state than the white-fleshed genotypes used as checks.
Bankruptcy Prediction: The Case of the Greek Market
Authors: Papana Angeliki , Spyridou Anastasia
Published: December 2020

Financial bankruptcy prediction is an essential issue in emerging economies taking into consideration the economic upheaval that can be caused by business failures. The research on bankruptcy prediction is of the utmost importance as it aims to build statistical models that can distinguish healthy firms from financially distressed ones. This paper explores the applicability of the four most used approaches to predict financial bankruptcy using data concerning the case of Greece. A comparison of linear discriminant analysis, logit, decision trees and neural networks is performed. The results show that discriminant analysis is slightly superior to the other methods.
Can Comprehensive Geriatric Assessment Meet Frail Older People’s Needs? Results from the Randomized Controlled Study CGA-Swed
Authors: Westgård Theresa , Andersson Hammar Isabelle , Dahlin-Ivanoff Synneve , Wilhelmson Katarina
Published: December 2020

Background: The comprehensive geriatric assessment (CGA) designed to manage frail older people requiring acute medical care, is responsible for diagnostics, assessment, treatment, and planning while addressing a person’s medical, psychological, social, and functional capabilities. The aim was to investigate if CGA had an impact on frail older people’s activities of daily living (ADL) status, self-rated health, and satisfaction with hospital care. Methods: A two-armed design with frail people aged 75 or older who required an unplanned hospital admission were randomized to either the CGA ward or to an acute medical ward. Analyses were made based on the intention-to-treat principle (ITT). The primary outcome was ADL. Data were analyzed using Chi-square and odds ratio. A subgroup analysis was performed due to non-adherence and contamination. Results: One-hundred and fifty-five people participated in the study; 78 in the intervention and 77 in the control. Participants in the intervention group had a higher odds ratio of reporting having received written information and felt that care met their needs during their hospital stay. No additional statistically significant results for the primary or secondary outcomes in the ITT analysis were achieved. Conclusion: Participants felt that the care they received with the CGA ward met their needs. The lack of additional results supporting the CGA could be due to difficulties performing pragmatic intervention trials in clinical hospital settings, and because a CGA during one hospital stay is probably not enough to have long-term effects.
Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk
Authors: Sharma Sunita , Kho Alvin T. , Chhabra Divya , Haley Kathleen , Vyhlidal Carrie , Gaedigk Roger , Leeder J. Steven , Tantisira Kelan G. , Raby Benjamin , Weiss Scott T.
Published: December 2020

Background: In utero smoke (IUS) exposure is associated with asthma susceptibility. Objective: We sought to test the hypothesis that changes in miRNA expression by IUS exposure during human lung development is associated with asthma susceptibility. Methods: Gene expression was profiled from 53 IUS unexposed and 51 IUS exposed human fetal lung tissues. We tested for the differential expression of miRNAs across post-conception age and by IUS using linear models with covariate adjustment. We tested the IUS-associated miRNAs for association with their gene expression targets using pair-wise inverse correlation. Using our mouse model, we investigated the persistence of the IUS-associated miRNA signature using RT-PCR from the lungs of mouse pups with and without IUS at postnatal day 14. MiRNAs were then tested for association with asthma and exacerbations using whole blood gene expression profiles from Asthma BRIDGE. Results: Five miRNAs were differentially expressed across post-conception age (adjusted p < 0.0002) including two that were differentially expressed by IUS exposure in human fetal lung (p < 0.05). MiR-15a was differentially expressed by post-conception age (p = 0.00002), IUS exposure in human fetal lung (p = 0.005), and in the post-natal mouse lung (p = 0.01). MiR-15a was also associated with the in utero expression of GSDMB (adjusted p = 0.0002), a known childhood asthma gene and with asthma exacerbations (p = 0.0009) in Asthma BRIDGE. Thus, miR-15a is expressed during human lung development, is impacted by IUS exposure, regulates the intrauterine expression of asthma genes, and is associated with asthma severity. Conclusions: These results provide evidence for the role of miR-15a in the fetal origin of asthma.
External Validation of a Population-Based Prediction Model for High Healthcare Resource Use in Adults
Authors: Rosella Laura C. , Kornas Kathy , Sarkar Joykrishna , Fransoo Randy
Published: December 2020

Predicting high healthcare resource users is important for informing prevention strategies and healthcare decision-making. We aimed to cross-provincially validate the High Resource User Population Risk Tool (HRUPoRT), a predictive model that uses population survey data to estimate 5 year risk of becoming a high healthcare resource user. The model, originally derived and validated in Ontario, Canada, was applied to an external validation cohort. HRUPoRT model predictors included chronic conditions, socio-demographics, and health behavioural risk factors. The cohort consisted of 10,504 adults (≥18 years old) from the Canadian Community Health Survey in Manitoba, Canada (cycles 2007/08 and 2009/10). A person-centred costing algorithm was applied to linked health administrative databases to determine respondents’ healthcare utilization over 5 years. Model fit was assessed using the c-statistic for discrimination and calibration plots. In the external validation cohort, HRUPoRT demonstrated strong discrimination (c statistic = 0.83) and was well calibrated across the range of risk. HRUPoRT performed well in an external validation cohort, demonstrating transportability of the model in other jurisdictions. HRUPoRT’s use of population survey data enables a health equity focus to assist with decision-making on prevention of high healthcare resource use.
Natal and Neonatal Teeth: A Case Report and Mecanistical Perspective
Authors: Anton Emil , Doroftei Bogdan , Grab Delia , Forna Norina , Tomida Mihoko , Nicolaiciuc Ovidiu Sebastian , Simionescu Gabriela , Ancuta Eugen , Plopa Natalia , Maftei Radu , Ilea Ciprian , Anton Carmen
Published: December 2020

The presence of teeth on babies earlier than four months is a rare condition. Therefore, adequate treatment for each case should be instituted as soon as possible, considering that certain complications may arise. This report describes a rare case in which a newborn baby required the extraction of two mobile mandibular natal teeth to prevent the risk of aspiration. After two years, the clinical re-evaluation showed a residual tooth instead of a temporary one. This case report shows that adequate diagnosis should include a radiographic examination to determine whether these teeth are components of normal or supernumerary dentition, as well as further investigations on the relationship with the adjacent teeth. Another important aspect highlighted in this case report is the need for a post-extraction curettage of the socket in order to reduce the risk of ongoing development of the dental papilla cells.
Assessment of a Hands-On Seminar on Gastrointestinal Ultrasound
Authors: Yamada Masaaki , Hasegawa Yuichi , Yamashiro Seiji , Sekine Michikazu , Asano Yukihiro , Fujinami Haruka
Published: December 2020

Transabdominal gastrointestinal (GI) ultrasound (US), despite its utility, is not a common procedure and underappreciated owing to its difficulty to perform. This study aimed to disseminate the skills of GIUS and assess the impact of our hands-on seminar. We annually held a half-day, hands-on seminar on GIUS at University of Toyama Hospital for physicians and sonographers from 2015 to 2017. Two months after the seminar, we inquired about clinical attainment by questionnaire. Out of 55 participants, 46 (83.6%) returned their questionnaires. Twenty participants (43.5%) reported that they had successfully diagnosed at least one GI disorder via GIUS since the seminar. Residual analyses stratified by the participants’ background showed that the novices, those having < 2 years’ experience in performing abdominal US, or no prior knowledge of GIUS, had significantly lower attainment rates (23.5% and 12.5%, respectively) than the others. Participants with 2 to 5 years’ experience in performing abdominal US or with some knowledge of GIUS had much higher rates of diagnosing GI disorders (54.5% and 57.9%, respectively). Nearly half of the participants had identified GI disorders using GIUS in 2 months following the training. The hands-on seminar was beneficial in disseminating these skills among a wide range of US operators.
Co-Design of a Playful Mixed Reality Installation: An Interactive Crane in the Museum of Marble Crafts
Authors: Vosinakis Spyros , Nikolakopoulou Vasiliki , Stavrakis Modestos , Fragkedis Labros , Chatzigrigoriou Pavlos , Koutsabasis Panayiotis
Published: December 2020

Interactive installations in museums usually adopt hybrid technologies that combine physical elements with digital content, and studies so far show that this approach enhances the interest and engagement of visitors compared to non-interactive media or purely digital environments. However, the design of such systems is complicated, as it involves a large number of stakeholders and specialists. Additionally, the functional components need to be carefully orchestrated to deliver a rich user experience. Thus, there is a need for further research on tools and methods that facilitate the process. In this paper we present the design and development of a mixed reality installation for the Museum of Marble Crafts in Tinos island in Greece, which places visitors in the role of the crane operator and they have to complete challenges in a gamified version of the old quarry. The system lets users operate a tangible controller and their actions are executed by digital workers in a rich 3D environment. Our design approach involved iterative prototyping, research and co-design activities. The creative process has been supported by a series of organized workshops. The evaluation results indicate that mixed reality can be a promising medium for rich interactive experiences in museums that combine tangible and intangible heritage.
Influences of Blood Lactate Levels on Cognitive Domains and Physical Health during a Sports Stress. Brief Review
Authors: Coco Marinella , Buscemi Andrea , Ramaci Tiziana , Tusak Matej , Corrado Donatella Di , Perciavalle Vincenzo , Maugeri Grazia , Perciavalle Valentina , Musumeci Giuseppe
Published: December 2020

The present review aims to examine the effects of high blood lactate levels in healthy adult humans, for instance, after a period of exhaustive exercise, on the functioning of the cerebral cortex. In some of the examined studies, high blood lactate levels were obtained not only through exhaustive exercise but also with an intravenous infusion of lactate while the subject was immobile. This allowed us to exclude the possibility that the observed post-exercise effects were nonspecific (e.g., cortical changes in temperature, acidity, etc.). We observed that, in both experimental conditions, high levels of blood lactate are associated with a worsening of important cognitive domains such as attention or working memory or stress, without gender differences. Moreover, in both experimental conditions, high levels of blood lactate are associated with an improvement of the primary motor area (M1) excitability. Outside the frontal lobe, the use of visual evoked potentials and somatosensory evoked potentials allowed us to observe, in the occipital and parietal lobe respectively, that high levels of blood lactate are associated with an amplitude’s increase and a latency’s reduction of the early components of the evoked responses. In conclusion, significant increases of blood lactate levels could exercise a double-action in the central nervous system (CNS), with a protecting role on primary cortical areas (such as M1, primary visual area, or primary somatosensory cortex), while reducing the efficiency of adjacent regions, such as the supplementary motor area (SMA) or prefrontal cortex. These observations are compatible with the possibility that lactate works in the brain not only as an energy substrate or an angiogenetic factor but also as a true neuromodulator, which can protect from stress. In this review, we will discuss the mechanisms and effects of lactic acid products produced during an anaerobic exercise lactate, focusing on their action at the level of the central nervous system with particular attention to the primary motor, the somatosensory evoked potentials, and the occipital and parietal lobe.
The Two-Minute Walk Test in Persons with Multiple Sclerosis: Correlations of Cadence with Free-Living Walking Do Not Support Ecological Validity
Authors: Karle Viktoria , Hartung Verena , Ivanovska Keti , Mäurer Mathias , Flachenecker Peter , Pfeifer Klaus , Tallner Alexander
Published: December 2020

The two-minute walk test (2MWT) is a frequently used walking capacity test in persons with multiple sclerosis (pwMS). However, less is known about its relevance with regards to walking capacity during free-living walking performance. Therefore, the ecological validity of the 2MWT was tested by 1. computing free-living minutes with the same intensity (cadence) as during the 2MWT and 2. investigating the relationship between 2MWT cadence and minutes with the same cadence during free-living walking. 20 pwMS aged 44.2 ± 12.2 (Expanded Disability Status Scale (EDSS) score of 3.1 ± 1.4) performed a 2MWT and wore an accelerometer for seven days. The number of pwMS reaching 100%, 90%, 80% or 70% of 2MWT cadence for at least one minute a day and minutes/day with at least 100%, 90%, 80% and 70% of 2MWT cadence during free-living walking was calculated. Six participants reached 100% of the 2MWT cadence for at least one minute/day during free-living walking. A total of 80% 2MWT cadence was the first intensity category that was reached by all participants during free-living walking. No significant correlation was found between cadence in the 2MWT and minutes in which this cadence was reached during free-living walking. Ecological validity with regard to walking intensity could not be confirmed in our study sample.
Perspective of Internet Poker Players on Harm-Reduction Strategies: A Cross-Sectional Study
Authors: Michalska Patrycja , Chatton Anne , Penzenstadler Louise , Izdebski Paweł , Jeannot Emilien , Simon Olivier , Dufour Magali , Rochat Lucien , Lischer Suzanne , Khazaal Yasser
Published: December 2020

Background: Internet gambling may increase rates of gambling harm. This current study aimed to assess Internet poker players’ views on various harm-reduction (HR) strategies. It also examined differences in these views according to the games played (poker only vs. poker plus other gambling activities), indebtedness, and problem gambling severity. Methods: Internet poker players (n = 311; 94.2% Male) recruited online between 2012 and 2014 were included in the analyses and completed a survey on indebtedness, problem gambling severity index, and ten statements regarding HR features. Results: Among the whole sample, the most frequently endorsed HR strategy was setting money limits, specialized online help, and peer support forums. People who play poker only (70%) are less prone to endorse the utility of information on excessive gambling and specialized healthcare centers. No differences were found between those people with debt versus those without regarding HR assessment. Participants with severe problem gambling were more skeptical about HR strategies based on information on specialized healthcare centers. Conclusion: Setting money limits, online help, and peer support forums are the most commonly endorsed strategies. Future research is needed to evaluate the effectiveness of online harm reduction strategies.
Association between the New COVID-19 Cases and Air Pollution with Meteorological Elements in Nine Counties of New York State
Authors: Díaz-Avalos Carlos , Juan Pablo , Chaudhuri Somnath , Sáez Marc , Serra Laura
Published: December 2020

The principal objective of this article is to assess the possible association between the number of COVID-19 infected cases and the concentrations of fine particulate matter (PM2.5) and ozone (O3), atmospheric pollutants related to people’s mobility in urban areas, taking also into account the effect of meteorological conditions. We fit a generalized linear mixed model which includes spatial and temporal terms in order to detect the effect of the meteorological elements and COVID-19 infected cases on the pollutant concentrations. We consider nine counties of the state of New York which registered the highest number of COVID-19 infected cases. We implemented a Bayesian method using integrated nested Laplace approximation (INLA) with a stochastic partial differential equation (SPDE). The results emphasize that all the components used in designing the model contribute to improving the predicted values and can be included in designing similar real-world data (RWD) models. We found only a weak association between PM2.5 and ozone concentrations with COVID-19 infected cases. Records of COVID-19 infected cases and other covariates data from March to May 2020 were collected from electronic health records (EHRs) and standard RWD sources.
Erratum: Jesus, T.S., et al. Global Need for Physical Rehabilitation: Systematic Analysis from the Global Burden of Disease Study 2017. Int. J. Environ. Res. Public Health 2019, 16, 980
Authors: Jesus Tiago S. , Landry Michel D. , Hoenig Helen
Published: December 2020

The authors wish to add the following correction to their paper published in International Journal of Environmental Research and Public Health [...]
Underlying Principles of a Covid-19 Behavioral Vaccine for a Sustainable Cultural Change
Authors: Couto Kalliu Carvalho , Moura Lorenzo Flora , Tagliabue Marco , Henriques Marcelo Borges , Freitas Lemos Roberta
Published: December 2020

Until pharmacological measures are effective at containing the COVID-19 outbreak, adopting protective behaviors is paramount. In this work, we aim at informing interventions to limit the spread of the contagion and prepare against any future outbreaks by developing a behavioral framework to interpret and prescribe both the individual and large-scale uptake of non-pharmaceutical measures. First, we analyze the barriers and facilitators to adherence to protective behaviors according to a three-term contingency by exploring potential gaps in terms of setting stimuli, motivating operations, delayed consequences, and positive or negative consequences. We explore their roles in the likelihood of individual compliance to protective behaviors, taking physical distancing as an example of functional analysis. Second, we interpret contagion control as the cumulative effect of large-scale adherence to protective behaviors. We explore the interrelations between societal problems caused or amplified by similar behaviors presented by many individuals and the coordination of agents or agencies aiming at promoting large-scale behavioral change. Then, we highlight the potential of developing a behavioral vaccine, and practical steps for applying it to promote sustainable cultural change that may protect against health, social, and economic losses in future outbreaks.
Assessment of Changes in Land Use/Land Cover and Land Surface Temperatures and Their Impact on Surface Urban Heat Island Phenomena in the Kathmandu Valley (1988–2018)
Authors: Sarif Md. Omar , Rimal Bhagawat , Stork Nigel E.
Published: December 2020

More than half of the world’s populations now live in rapidly expanding urban and its surrounding areas. The consequences for Land Use/Land Cover (LULC) dynamics and Surface Urban Heat Island (SUHI) phenomena are poorly understood for many new cities. We explore this issue and their inter-relationship in the Kathmandu Valley, an area of roughly 694 km2, at decadal intervals using April (summer) Landsat images of 1988, 1998, 2008, and 2018. LULC assessment was made using the Support Vector Machine algorithm. In the Kathmandu Valley, most land is either natural vegetation or agricultural land but in the study period there was a rapid expansion of impervious surfaces in urban areas. Impervious surfaces (IL) grew by 113.44 km2 (16.34% of total area), natural vegetation (VL) by 6.07 km2 (0.87% of total area), resulting in the loss of 118.29 km2 area from agricultural land (17.03% of total area) during 1988–2018. At the same time, the average land surface temperature (LST) increased by nearly 5–7 °C in the city and nearly 3–5 °C at the city boundary. For different LULC classes, the highest mean LST increase during 1988–2018 was 7.11 °C for IL with the lowest being 3.18 °C for VL although there were some fluctuations during this time period. While open land only occupies a small proportion of the landscape, it usually had higher mean LST than all other LULC classes. There was a negative relationship both between LST and Normal Difference Vegetation Index (NDVI) and LST and Normal Difference Moisture Index (NDMI), respectively, and a positive relationship between LST and Normal Difference Built-up Index (NDBI). The result of an urban–rural gradient analysis showed there was sharp decrease of mean LST from the city center outwards to about 15 kms because the NDVI also sharply increased, especially in 2008 and 2018, which clearly shows a surface urban heat island effect. Further from the city center, around 20–25 kms, mean LST increased due to increased agriculture activity. The population of Kathmandu Valley was 2.88 million in 2016 and if the growth trend continues then it is predicted to reach 3.85 million by 2035. Consequently, to avoid the critical effects of increasing SUHI in Kathmandu it is essential to improve urban planning including the implementation of green city technologies.
A Big Data Reference Architecture for Emergency Management
Authors: Iglesias Carlos A. , Favenza Alfredo , Carrera Álvaro
Published: December 2020

Nowadays, we are witnessing a shift in the way emergencies are being managed. On the one hand, the availability of big data and the evolution of geographical information systems make it possible to manage and process large quantities of information that can hugely improve the decision-making process. On the other hand, digital humanitarianism has shown to be very beneficial for providing support during emergencies. Despite this, the full potential of combining automatic big data processing and digital humanitarianism approaches has not been fully realized, though there is an initial body of research. This paper aims to provide a reference architecture for emergency management that instantiates the NIST Big Data Reference Architecture to provide a common language and enable the comparison of solutions for solving similar problems.
Bit from Qubit. A Hypothesis on Wave-Particle Dualism and Fundamental Interactions
Authors: Chiatti Leonardo
Published: December 2020

In this article a completely objective decoherence mechanism is hypothesized, operating at the level of the elementary particles of matter. The standard quantum mechanical description is complemented with a phenomenological evolution equation, involving a scalar curvature and an internal time, distinct from the observable time of the laboratory. This equation admits solutions internal to the wave function collapse, and the classical instantons connected to these solutions represent de Sitter micro-spaces identifiable with elementary particles. This result is linked in a natural way to other research programs tending to describe the internal structure of elementary particles by means of de Sitter spaces. Both the possible implications in particle physics and those deriving from the conversion of quantum information (qubits) into classical information (bits) are highlighted.
The Rural Digital Divide in the Face of the COVID-19 Pandemic in Europe—Recommendations from a Scoping Review
Authors: Esteban-Navarro Miguel-Ángel , García-Madurga Miguel-Ángel , Morte-Nadal Tamara , Nogales-Bocio Antonia-Isabel
Published: December 2020

The COVID-19 pandemic has revealed the digital vulnerability of many citizens of the rural world. This article identifies and analyzes the proposals made by academic literature to overcome the digital divide in the European rural world for the five-year period 2016–2020. A scoping review has been carried out according to the PRISMA methodology in the two dimensions of the digital divide: access and connectivity, and use and exploitation. Online databases were used to identify scientific articles from which, after screening, 28 key documents were selected. The results update Salemink systematic review of articles published between 1991 and 2014 on digital and rural development in Western countries and it also intends to go beyond by extracting recommendations. A variety of political, social, educational, technical and economic issues has been exposed, with a common emphasis on the empowerment of rural populations. The findings provide actionable evidence and proposals to facilitate decision-making in current policy information to overcome rural digital divide. From them, seven recommendations that could have a wide and rapid impact to minimize the effects of the COVID-19 pandemic linked to the rural digital divide are synthesized. Three lines of action in the medium term are also proposed: the evaluation of national and regional public policies; the consideration of digital inclusion as a potential instrument to reduce rural depopulation; and the training in advanced digital skills to improve the social communication processes, considered key to promote empowerment and entrepreneurship.
Selective Breeding for Low and High Varroa destructor Growth in Honey Bee (Apis mellifera) Colonies: Initial Results of Two Generations
Authors: De la Mora Alvaro , Emsen Berna , Morfin Nuria , Borges Daniel , Eccles Les , Kelly Paul G. , Goodwin Paul H. , Guzman-Novoa Ernesto
Published: December 2020

After two years of bidirectional selection for low and high rates of Varroa destructor population growth (LVG and HVG, respectively) in honey bee (Apis mellifera) colonies in Ontario, Canada, significant differences between the two genotypes were observed. LVG colonies had V. destructor population increases over the summer of 1.7 fold compared to 9.6 fold for HVG colonies by Generation 2. Additionally, HVG colonies had significantly higher mite infestation rates in adult bees compared to LVG colonies for both selected generations. DWV prevalence and levels were significantly higher in HVG colonies than in LVG colonies in Generation 1 but not in Generation 2. Winter mortality rates of Generation 1 colonies were significantly different at 26% and 14% for the HVG and LVG genotypes, respectively. The results of this study thus far indicate that selection for LVG may result in colonies with lower V. destructor infestation rates, lower prevalence, and levels of DWV and higher colony winter survivorship. Future work will focus on determining what mechanisms are responsible for the genotypic differences, estimating genetic parameters, and molecular analyses of the genotypes to identify candidate genes associated with resistance to V. destructor and DWV that could potentially be used for marker-assisted selection.
Natural Language Understanding for Multi-Level Distributed Intelligent Virtual Sensors
Authors: Mihailescu Radu-Casian , Kyriakou Georgios , Papangelis Angelos
Published: December 2020

In this paper we address the problem of automatic sensor composition for servicing human-interpretable high-level tasks. To this end, we introduce multi-level distributed intelligent virtual sensors (multi-level DIVS) as an overlay framework for a given mesh of physical and/or virtual sensors already deployed in the environment. The goal for multi-level DIVS is two-fold: (i) to provide a convenient way for the user to specify high-level sensing tasks; (ii) to construct the computational graph that provides the correct output given a specific sensing task. For (i) we resort to a conversational user interface, which is an intuitive and user-friendly manner in which the user can express the sensing problem, i.e., natural language queries, while for (ii) we propose a deep learning approach that establishes the correspondence between the natural language queries and their virtual sensor representation. Finally, we evaluate and demonstrate the feasibility of our approach in the context of a smart city setup.
Pharmacological Myopia Control Influence on Quality of Life and Psyche among Adolescents
Authors: Michalski Andrzej , Rogaczewska Małgorzata , Maleszka-Kurpiel Magdalena , Stopa Marcin
Published: December 2020

Myopia is a global problem affecting all aspects of patients’ lives. Objectives: The aim of the study was to evaluate the influence of low dose atropine (LDA) myopia control on the quality of life in patients with myopia. Material and Methods: A self-constructed questionnaire, including eight questions, was distributed among 40 patients. The questionnaire was divided into two subsections: (1) influence of LDA on visual functions and (2) influence of LDA on self-esteem. Answers were collected separately for boys (18 patients) and girls (22 patients) and compared considering spherical equivalent (SE) and myopia progression rate. Results: Girls reported more issues with near activities and pupil size. Boys and girls complained similarly, regarding the sun glare. We found a high level of certainty about the efficacy of LDA therapy among both examined groups and a little improvement in self-esteem. Girls recommended LDA therapy more often than boys, especially when the progression rate was low. There was no statistically significant difference in answer scores between groups with different myopia progression rates for boys. Girls with lower progression rates reported more issues with near work and sun glare and less trust in LDA therapy’s effectiveness than girls with a higher progression rate. There was no statistically significant correlation between SE and the total answer score for both genders. Conclusions: Findings concerning childrens’ and adolescents’ psyche are a new aspect of myopia control. We prove that patients during pharmacological myopia control did not report significant problems caused by LDA therapy and they were convinced about its efficacy, had greater self-esteem, and recommended it to peers.
The Relationship between Problematic Facebook Use and Early Maladaptive Schemas
Authors: Cudo Andrzej , Mącik Dorota , Griffiths Mark D. , Kuss Daria J.
Published: December 2020

Facebook is an increasingly popular online social media platform for communication, entertainment, and information exchange. Previous studies have shown the relationship between problematic Facebook use (PFU) and mental health problems. Additionally, previous studies have reported associations between maladaptive cognitive schemas and mental health problems. However, little is known about their impact on problematic behavior associated with Facebook use. Consequently, the present study investigated the relationship between PFU and early maladaptive schemas (EMSs) among Facebook users. The study comprised 619 Facebook users (568 females; age range from 18 to 30 years; M = 21.34, SD = 2.41 years). The severity of PFU was assessed using the Facebook Intrusion Scale, and EMS dimensions were assessed using the 90-item Young Schema Questionnaire (YSQ–S3). The findings showed a positive relationship between PFU and EMSs, such as insufficient self-control/self-discipline and approval seeking. PFU was negatively associated with EMSs, such as social isolation/alienation and self-sacrifice schemas. Additionally, the findings showed that EMSs, as well as Facebook use characteristics, such as the time spent using Facebook per week, using Facebook apps, and number of friends on Facebook contributed to explaining the variance in PFU scores. These findings may contribute to a better understanding of mechanisms related to the development of PFU, which are associated with cognitive schemas. Additionally, the results may be useful in developing more effective methods of prevention and treatment of this problematic behavior.
Serum Levels of Glutamate-Pyruvate Transaminase, Glutamate-Oxaloacetate Transaminase and Gamma-Glutamyl Transferase in 1494 Patients with Various Genotypes for the Alpha-1 Antitrypsin Gene
Authors: Hernández Pérez José María , Blanco Ignacio , Jesús Sánchez Medina Agustín , Díaz Hernández Laura , Antonio Pérez Pérez José
Published: December 2020

Background: Patients with liver disease associated with alpha-1 antitrypsin deficiency (AATD) are homozygous for the Z mutation, leading to chronic liver damage. Objective: To assess the serum levels of glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), and gamma-glutamyl transpeptidase (GGT) in patients with different genotypes for the alpha-1 antitrypsin (AAT) gene. Methods: Patients (n = 1494) underwent genotyping of the SERPINA1 gene, together with a determination of AAT and GOT and GPT and GGT transaminase levels. Patients with a deficient allele (n = 476) and with a normal genotype were compared. Results: A statistically significant association was found between deficient genotypes and GOT (p < 0.0003), GPT (p < 0.002), and GGT (p < 0.006). Comparing GOT levels in patients with PI*Z deficient variant versus those with normal genotype, an odds ratio (OR) of 2.72 (CI: 1.5–4.87) (p < 0.0005) was obtained. This finding was replicated with the PI*Z allele and the GPT values (OR = 2.31; CI: 1.45–3.67; p < 0.0003). In addition, a statistically significant association was found between liver enzymes and AAT values. Conclusion: The PI*Z allele seemed to be a risk factor for the development of liver damage. AAT deficient genotypes were associated with GOT, GPT, and GGT altered values. Low AAT levels were associated with high GPT and GGT levels.
The Incremental Role of Coronary Computed Tomography in Chronic Coronary Syndromes
Authors: Baessato Francesca , Guglielmo Marco , Muscogiuri Giuseppe , Baggiano Andrea , Fusini Laura , Scafuri Stefano , Babbaro Mario , Mollace Rocco , Collevecchio Ada , Guaricci Andrea I. , Rabbat Mark , D’Andrea Antonello , Pontone Gianluca
Published: December 2020

In the context of chronic coronary syndromes (CCS), coronary computed tomography angiography (CCTA) has gained broad acceptance as a noninvasive anatomical imaging tool with ability of excluding coronary stenosis with strong negative predictive value. Atherosclerotic plaque lesions are independent predictors of cardiovascular outcomes in high risk patients with known coronary artery disease (CAD). Calcium detection is commonly expressed through the coronary artery calcium score (CACS), but further research is warranted to confirm the powerness of a CACS-only strategy in both diagnosis and prognosis assessment. Recent studies evidence how defined plaque composition characteristics effectively relate to the risk of plaque instabilization and the overall ischemic burden. Fractional flow reserve from CCTA (FFR-CT) has been demonstrated as a reliable method for noninvasive functional evaluation of coronary lesions severity, while the assessment of perfusion imaging under stress conditions is growing as a useful tool for assessment of myocardial ischemia. Moreover, specific applications in procedural planning of transcatheter valve substitution and follow-up of heart transplantation have gained recent importance. This review illustrates the incremental role of CCTA, which can potentially revolutionize the diagnosis and management pathway within the wide clinical spectrum of CCS.
The Pharmacological Approach to Oncologic Patients with Acute Coronary Syndrome
Authors: Radmilovic Juri , Di Vilio Alessandro , D’Andrea Antonello , Pastore Fabio , Forni Alberto , Desiderio Alfonso , Ragni Massimo , Quaranta Gaetano , Cimmino Giovanni , Russo Vincenzo , Scherillo Marino , Golino Paolo
Published: December 2020

Among acute coronary syndrome (ACS) patients, 15% have concomitant cancer, especially in the first 6 months after their diagnosis, as well as in advanced metastatic stages. Lung, gastric, and pancreatic cancers are the most frequent malignancies associated with ACS. Chemotherapy and radiotherapy exert prothrombotic, vasospastic, and proinflammatory actions. The management of cancer patients with ACS is quite challenging: percutaneous revascularization is often underused, and antiplatelet and anticoagulant pharmacological therapy should be individually tailored to the thrombotic risk and to the bleeding complications. Sometimes oncological patients also show different degrees of thrombocytopenia, which further complicates the pharmacological strategies. The aim of this review is to summarize the current evidence regarding the treatment of ACS in cancer patients and to suggest the optimal management and therapy to reduce the risk of adverse coronary events after ACS in this high-risk population.
Relationship between Age-Dependent Body Constitution and Temporomandibular Joint Sounds in Adolescents
Authors: Rauch Angelika , Körner Antje , Kiess Wieland , Hirsch Christian , Schierz Oliver
Published: December 2020

To date, risk factors for temporomandibular joint (TMJ) sounds are still not completely understood, and anatomical factors are suspected to influence their occurrence. This study aimed to evaluate the impact of body constitution on temporomandibular joint sounds of adolescents. 10- to 18-year-old participants of the LIFE Child Study were examined for TMJ sounds, and physical parameters such as body height, body weight, and general laxity of joints were measured. Odds ratios (OR) for associations of TMJ sounds and standard deviation scores (SDS) of body height and body weight were calculated by using binary logistic regression, including cofactors such as age and number of hypermobile joints. The OR for TMJ sounds and SDS of body height was 1.28 (95% confidence interval (CI) 1.06; 1.56) in females when the age-adjusted height value was above 0. SDS of body weight indicated significant ORs for TMJ sounds in males with values of 0.81 (95% CI 0.70; 0.94). No correlation was detected for SDS values and TMJ crepitus. Tall female adolescents seem to be more prone to TMJ clicking sounds, while their occurrence seems less likely in male adolescents with higher body weight.
Pediatric Miller Fisher Syndrome; Characteristic Presentation and Comparison with Adult Miller Fisher Syndrome
Authors: Jang Yeonji , Choi Jae-Hwan , Chae Jong Hee , Lim Byung Chan , Kim Seong-Joon , Jung Jae Ho
Published: December 2020

Background: We aimed to investigate the characteristic presentation of Miller Fisher syndrome (MFS) in pediatrics and compare it with that in adults. Methods: We performed a retrospective review of medical records, laboratory findings, and disease course of pediatric MFS. The data were compared with those of adult MFS, and literature review was done. Unpaired and paired comparisons between groups were made using Wilcoxon rank-sum and signed-rank tests, respectively. Results: Median age for pediatric MFS was 9.8 ± 6.5 years. There were 5 (45.5%) male and 6 (54.5%) female patients. All patients had preceding infection. Two patients (22.2%) had tested positive for anti-GQ1b antibody. Ten patients (90.1%) were treated with intravenous immunoglobulin, and 2 (18.2%) also received intravenous methylprednisolone. Within one month, 8 (72.7%) patients showed recovery, and all 11 (100%) recovered fully within 3 months. Further, the pediatric group had higher frequency of unilateral involvement of ophthalmoplegia, ataxia, and autonomic symptoms but lower antiganglioside antibody positivity and manifestations of areflexia than the adult group. Conclusions: Neuro-ophthalmic manifestations and disease course of pediatric MFS were similar to those of adult MFS as stated in the literature. However, the presence of autonomic symptoms was higher and anti-GQ1b antibody positivity was lower in pediatric MFS than in adult MFS.