bluuebunny/crossref_metadata_2025 huggingface dataset:
The Genetic Basis of Mutation Rate Variation in Yeast
Authors: Gou Liangke , Bloom Joshua S , Kruglyak Leonid
Published: December 2018

Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis of these differences. Here, we leveraged the power of the yeast Saccharomyces cerevisiae as a model system to uncover natural genetic variants that underlie variation in mutation rate. We developed a high-throughput fluctuation assay and used it to quantify mutation rates in seven natural yeast isolates and in 1040 segregant progeny from a cross between BY, a laboratory strain, and RM, a wine strain. We observed that mutation rate varies among yeast strains and is heritable (H2 = 0.49). We performed linkage mapping in the segregants and identified four quantitative trait loci underlying mutation rate variation in the cross. We fine-mapped two quantitative trait loci to the underlying causal genes, RAD5 and MKT1, that contribute to mutation rate variation. These genes also underlie sensitivity to the DNA-damaging agents 4NQO and MMS, suggesting a connection between spontaneous mutation rate and mutagen sensitivity.
Ovarian Dysgerminoma with Metastases in Supraclavicular Lymph Nodes Diagnosed in a 16-year-old Girl: Clinical Case and Literature Review
Authors: Maldžiūtė Diana , Rukauskaitė Vilma , Trainavičius Kęstutis
Published: December 2018

[full article, abstract in English; abstract in Lithuanian]

Background

Tumors of children reproductive system are rare, the most frequent among them is ovarian tumor. The most frequent histological type of ovarian tumor in girls and adolescents is germ cell tumor, with dysgerminoma being the most frequent of all. Symptoms are very non-specific, this is why these tumors are often diagnosed late. Dysgerminoma is a malignant tumor, thus if not treated, it may be potentially lethal.

Case report

We present a 16-year old patient, who has come to Vilnius University Hospital Santaros Klinikos, Children’s unit, due to a sudden emergence of a growth above the left clavicle. The girl did not have any other specific complaints. Huge hard growth was founded during palpation of the abdomen. After the cancer marker test (alfa-fetoprotein – 1,9 kU/L, beta-human chorionic gonadotropin – 1231.0 U/L; lactate dehydrogenase – 2721.0 U/L; Ca125 – 665.8 kU/L), pelvic ultrasound examination, computed tomography and histological evaluation of the supraclavicular mass, dysgerminoma of the right ovary FIGO stage IV was diagnosed. The patient was treated with laparotomic oophorectomy and chemotherapy before and after surgery. Treatment was successful as 100% of tumor cells necrosis was achieved.

Conclusions

Girls and adolescents should be suspect to ovarian masses if they complains about abdominal pain, a growth in the abdominal area, disruptions of menstrual cycle or signs of premature puberty. Early diagnosis and treatment of ovarian dysgerminoma have a very good recovery rate in girls and adolescent.
Biological farming in conditions of transformational changes in the agrarian production of Ukraine
Authors: Petrychenko V. , Korniychuk O. , Voronetska I.
Published: December 2018

Aim. To highlight the peculiarities of transformational changes in land use in agrarian production in terms of soil fertility and farming effi ciency in Ukraine. To carry out a comparative analysis of the effi ciency of use of land resources in different European countries. To substantiate approaches to farming biologization in conditions of intensifi cation of agrarian production and climate change. Methods. Observation, comparison, analysis and synthesis, system analysis and forecast. Results. The results of long-term fundamental and applied researches on the effect of intensifi cation of agriculture on the productivity level of agrarian production have been analyzed. A benchmarking analysis of the effi ciency of use of land resources in Ukraine and European countries has been carried out. It has been established that as a result of economic activity the basic principle of interaction between the agriculture and livestock sector was violated, which does not allow to combine ef- fectively and use the intensifi cation factors, the principle of fruit variability is not applied when introducing short crop rotations of the market crops. Conclusions. The effectiveness of agrarian production in conditions of transformational changes depends on the biological farming, which should be targeted at the rational use of land resources, prevention of degradation, preservation and enhancement of soil fertility and sustainable land use in time, use of life factors of agricultural plants taking into account their biological requirements.
Morphogenesis of Miscanthus × Giganteus in vitro
Authors: Klyachenko O. , Nekrut O.
Published: December 2018

Aim. To obtain planting material of Miscanthus × giganteus in a large amount in order to study the peculiari- ties of morphogenesis of isolated meristem culture. Methods. The explants were sterilized using 70 % etha- nol and 0.1 % mercury bichloride, after that, the methods of plant cultivation and reproduction in vitro and statistical processing of the obtained data was performed. Results. The study presents the results of obtaining the regenerate plants from dormant buds of 3-year-old rhizomes of Miscanthus × giganteus. The Murashige and Skoog medium supplemented with 6-benzylaminopurine (BAP) (0.75 mg/L) and kinetin (1.2 mg/L) was found to be the best for regeneration of microsprouts, providing the maximum value of the regeneration index (95 %) and contributing to the development of the main sprouts and tillering. The obtained sprouts were rooted in Murashige and Skoog medium supplemented with half-dose of macro- and micronutrients without growth regulators. In doing so, rooting index made up 95.0–97.0 %.
The best substrate for the adaptation of miscan- thus plants in vivo was found to be a mixture of peat, sand, and perlite in a ratio of 2 : 1 : 1, respectively. In this substrate, plant establishment reached 91 %. Conclusions. The peculiarities of morphogenesis in Miscan- thus × giganteus isolated meristem were studied. At the same time, the index of sprouts regeneration varied from 90.0 to 100.0 %. In addition, the development of the main sprout and multiple tillering occurred in 85.0– 100.0 % explant. The highest survivability of micro-plants (91–95 %) was provided in the peat-sand-perlite substrate in a ratio of 2 : 1 : 1.
Pengembangan Model Pencegahan Anak-Anak Terminal dari Kekerasan Sosial dengan Pendekatan Berbasis Kekuatan dan Kewirausahaan Sosial
Authors: Wibowo Hery
Published: December 2018

Social violence is an issue that is always present throughout the life of human civilization. Social violence comes very close to human life in various domains of life. One thing to note from social violence is its potential to make children (and other young people) are victims and perpetrators of violence themselves socially. Social Welfare, actually has several approaches, perspectives and instruments to interact with issues of social violence. However, it is less often discussed in the scientiﬁ c writing. This paper attempts to model the handling of violence through social welfare income and social entrepreneurship. Keywords: kekerasan sosial, pendekatan kesejahteraan, social entrepreneurship.
Isolasi dan Identifikasi Senyawa Seskuiterpen dari Curcuma soloensis Val. (Temu Glenyeh)
Authors: Marliyana Soerya Dewi , Wartono Muhamad Widyo , Wibowo Fajar Rakhman , Munasah Gesti
Published: December 2018

Curcuma soloensis Val. is a family plant Zingiberaceae and is known as "temu gelnyeh". This plant has been used as a medicinal plant but has not been widely reported about its chemical components. Therefore, this study was carried out to isolation and identification of the chemical components of the C. soloensis Val. rhizome. Isolation was done by extraction, fractionation, and purification. The fractionation and purification of the compound were carried out using chromatography methods. The identification of the compound was determined by spectroscopic methods including 1D-NMR (1H NMR, 13C NMR) and 2D-NMR (HSQC, HMBC). Based on NMR spectra data analysis and compared with literature, the compound obtained yellow liquid was ar-turmerone (2-methyl-6- (4-methylphenyl) hept-2-en-4-on) which was a terpenoid sesquiterpene. Ar-turmerone is the first compound that found from Curcuma soloensis Val. rhizome.
El compromiso con la racionalidad en el enfoque pragmadialéctico
Authors: Hoyos Morales Jorge Iván
Published: December 2018

El presente artículo aborda el tópico ‘racionalidad’ en la versión estándar del enfoque pragmadialéctico (PD) de argumentación, que  pretende superar la dicotomía, entre los aspectos normativo y descriptivo, existente en los estudios sobre argumentación. Se señala que la pragmadialéctica asume ciertos postulados popperianos al conceptualizar su noción de racionalidad, y dado que también incluye elementos de filósofos como Searle y Grice, se indaga si las ideas de racionalidad de estos filósofos están presentes en el compromiso con la racionalidad de los pragmadialécticos. Por otra parte se da cuenta de algunos nexos  entre el pensamiento aristotélico y los tres filósofos señalados con el fin de aclarar la concepción que tienen los pragmadialécticos acerca de la racionalidad, estimulando así un regreso enriquecedor a las fuentes de la argumentación.
Figuras de lo humano en Judith Butler La reivindicación de un espacio político entre la antropología y el antihumanismo
Authors: Ingala Gómez Emma
Published: December 2018

Si bien la crítica antihumanista de la categoría de lo humano tenía un objetivo eminentemente emancipador, ha desembocado en los últimos años en una paradoja vinculada a la defensa del carácter construido y, por tanto, descualificado de lo humano. Para responder a esta paradoja, varios filósofos ubicados en el espacio teórico del antihumanismo se han visto forzados a repensar, y en cierto modo a recuperar, lo humano. Judith Butler ofrece uno de los tratamientos más sofisticados de esta cuestión en la medida en que propone, según nuestra hipótesis, no un nuevo concepto de lo humano o un nuevo humanismo, sino distintas figuras de lo humano articuladas en torno a dos vértebras fundamentales: la impropiedad y la precariedad. Al explorar la tensión que modula la relación entre estas dos vértebras, sostenemos que Butler estaría sentando las bases para una antropología política crítica, antihumanista y no antropocéntrica.
El papel político de la superstición y el deseo en Spinoza. Consideraciones actuales sobre el capitalismo
Authors: Cápona González Daniela
Published: December 2018

Se analiza el concepto de superstición de Spinoza como dispositivo político de alteración de la lógica afectiva y, por ende, del deseo, instituyendo determinadas formas de acción y pensamiento. En virtud de lo anterior, se propone una lectura sobre su devenir conceptual, considerando las nociones de fetichismo en Marx, religión capitalista en Benjamin, espectáculo en Debord y discurso moral en Coccia, de esta manera se pone en evidencia la actualidad del funcionamiento de la superstición en la época del capitalismo.
Descartes y el diablo. La oratoria del mal
Authors: Pavesi Pablo
Published: December 2018

En la Carta a Voetius, Descartes escribe que su enemigo es el diablo, el enemigo. La acusación es etimológicamente coherente (Voetius es el calumniador, cuya palabra divide a los hombres) e introduce una excepción a la metafísica, una voluntad de mal. Finalmente, la malignidad odia la verdad (absurditas): es deliberadamente irracional. Examinamos aquí la oratoria del mal: primero, sus recursos retóricos (en confrontación con la retórica de Guez de Balzac); segundo, las pasiones que excita (en confrontación con Las pasiones del alma) y su combinación en una pasión particular, la cólera piadosa; tercero, sus efectos: la disolución del vínculo civil entre ciudadanos y amistoso entre familiares.
Crítica e normatividade: considerações acerca da solidariedade política e do orçamento participativo
Authors: Assai Henrique Sousa
Published: December 2018

A filosofia política e a filosofia social têm se deparado ultimamente com desafios normativos que exigem cada vez mais esforços para respondê-los. Dentre eles está certamente o vertiginoso processo de despolitização da esfera pública que solapa a vida societária. Urge, portanto, sob o ponto de vista da pesquisa crítica, propor respostas para o referido problema. Este artigo pretende explicitar, baseado no pensamento crítico-reflexivo, a ação social de cunho solidário do orçamento participativo como possibilidade de responder ao processo de despolitização da esfera pública. Nesse sentido, o projeto da deliberação orçamentária pode contribuir para a sociedade mediante a ação repolitizadora na esfera pública na medida em que ele se constitui enquanto medium sócio-normativo na sociedade.
Socialismo, liberalismo e educação para a democracia: Honneth e Dewey em discussão
Authors: Petry Franciele
Published: December 2018

O presente trabalho tem como objetivo discutir o livro de Axel Honneth, A ideia de socialismo, publicado em 2015, à luz de considerações feitas a partir dos trabalhos de John Dewey, Liberalism and social action (1935) e Democracia e educação (1916). Busca-se examinar a aproximação entre a proposta de socialismo de Honneth e a defesa de um novo liberalismo feita por Dewey. O trabalho sugere que a proposta de Honneth apresenta dificuldades decorrentes de uma apropriação insuficiente das ideias de Dewey, principalmente no que diz respeito ao papel da educação na formação da vontade democrática necessária à cooperação social.
‘The king, my lord, wrote me in a tablet: “…” ’ (EA 149:54 – 55): direct citation and communication in the syro-canaanite el-amarna letters
Authors: Breier Idan
Published: December 2018

This paper examines the use of direct citation in the correspondence between the Egyptian Pharaoh and his officials and his Syro-Canaan vassals in the El-Amarna archive. A frequent phenomenon in the modern and ancient world alike, direct citation serves to support the writer’s claims, lay the blame on or absolve others, demonstrate loyalty, and depict distress. The examples adduced fall into four categories: authoritative, third-party, confirmative, and fabricated/ imaginary speech. Raising the question of the validity of applying modern linguistic theories to ancient sources, these types are analysed in the light of the international diplomacy that flourished in the Fertile Crescent during the 14th-century BCE.
Revolt of the nabataean damaṣî in the light of new epigraphic material evidence
Authors: Al-Rawabdeh Nada , Qader Al-Husan Abdel
Published: December 2018

This paper sheds light on a new Ancient North Arabian (Safaitic) inscription that makes mention of the famous Nabataean Damaṣî. This is the fourth known Safaitic inscription to contain a reference to Damaṣî; the paper makes a comparison of the appearances of Damaṣî in the known corpus and evaluates the historical context. The significance of this inscription lies in its description of the author waiting (nẓr) for Damaṣî.
QURAISY DAN HEGEMONI KUASA ATAS AGAMA; Studi Analitis Ilmu Hadis dan Sosial
Authors: Nurrohman Muhammad Ridwan
Published: December 2018

This paper aims to re-examine one of the themes in the Prophet's hadith, namely "al-aimmatu min Quraish". Ahlu Sunnah, understand the point "descendants of Quraysh" in the preconditions of Imamat as an ijma '. Although this does not close the opportunity to present thinkers who reject the consensus. But when testing this hadith in terms of hadith, social, and historical reality. It is proven that what is a sunnah consensus is not a blind dogma, let alone merely a political tool. But it is another sign, the truth of Muhammad's prophethood.
Modelo conceptual y tecnológico para apoyo a niños con discalculia
Authors: Parra María Alejandra Hurtado , Duque-Méndez Néstor Darío
Published: December 2018

Usualmente en los ambientes educativos, tanto virtuales como presenciales, las actividades y estrategias de aprendizaje son generalizadas y buscan atender multimodal y homogéneamente a todos los estudiantes, sin reconocer las diferencias existentes. En el caso particular de la enseñanza primaria, los ambientes educativos involucran estudiantes con diversas características y ritmos cognitivos, entre ellos niños con dificultades de aprendizaje, que se ven afectados con actividades de enseñanza y aprendizaje únicas y para todos.Los niños en edad escolar que presentan dificultades de aprendizaje pueden retardar su proceso académico, pues requieren de actividades de aprendizaje acordes a su situación. Si no se identifican y atienden a tiempo estas dificultades el día a día de los niños puede verse afectado negativamente, no solo en lo académico sino en lo social y personal.El artículo presenta un modelo conceptual y un entorno informático educativo basado en actividades educativas encaminadas a niños con dificultades de aprendizaje relacionadas con la matemática, que permita la detección temprana y así mismo apoyen las estrategias específicas para el nivel de dificultad encontrada permitiendo realizar el seguimiento de la evolución de cada estudiante.
Ekonomia doświadczeń w kształtowaniu konkurencyjności regionów turystycznych
Authors: Gryszel Piotr
Published: December 2018

Contemporary tourist attractions that McDonaldsize and Disneyize the product they offer tourists are very well-received and are often the main reason tourist trips are taken. Thus, they significantly boost the competitiveness of their regions’ tourism. Based on an examination of the subject literature and surveys of tourists visiting the Sudety Mountain as a tourist region, the article assesses the impact of contemporary tourist attractions, creating the experience of tourists, on the competitiveness of the tourist region. The analysis included entries, evaluations and statements expressed in TripAdvisor’s app, and referring to tourist attractions located in the tourist region studied. The contemporary approach associated with the experience economy is one of the most effective tools for creating the competitive position of the Sudety tourist market.
Uwarunkowania lojalności klientów biur podróży
Authors: Michalska-Dudek Izabela
Published: December 2018

The article presents the results of the author’s research identifying the key determinants of loyalty among travel agency clients. It also develops a profile of a loyal customer of travel agency services. The analysis covers real historical data, taken from the accounting and booking system of one nationwide franchise of networks in Poland consolidating 60 agency offices and referring to 15,248 reservations made in the years 2013–2017 by clients who purchased tourist services. A non-parametric method of artificial neural networks was applied, while the most important determinants of behavioural loyalty were the following variables: the duration of the tour, the number of children under the age of 14 included in the booking, the price and the destination of the tourist event.
Wielowymiarowa analiza statystyczna w badaniach rynku kapitałowego
Authors: Budny Katarzyna , Tatar Jan
Published: December 2018

In their previous work, the authors have presented an approach to describing and researching multivariate probability distributions that departs from the standard. In this paper, the new tools that resulted have been used to research and analyse selected two-, three- and fourth-dimension random vectors that have appeared on the Polish capital market. Coordinates of these vectors are stock market indices: WIG, WIG-20, WIG-Banks, WIG-Fuels and profitability of these indices. Using market data for the period 4/1/16–7/7/17, the following estimators of parameters of analysed distributions were calculated and interpreted: expected value, total variance, total standard deviation, skewness coefficient, norm of the skewness coefficient, square of the skewness coefficient, kurtosis and excess coefficient. In order to overview and compare, for each vector a covariance matrix and a matrix of correlation coefficients are indicated. The following characteristics of marginal distributions are also used: expected value, variance, standard deviation, skewness coefficient, kurtosis and excess coefficient. For each pair of financial random vectors researched, the estimator of the square of correlation coefficient was also calculated, as that is one of the possible measures of their dependence.
Od klasycznych papierów wartościowych do zdematerializowanych instrumentów finansowych – ewolucja i perspektywy
Authors: Horosz Piotr
Published: December 2018

Focusing mainly on historical issues, the article presents the process by which securities admitted to public trading in the 1990s (with the total dematerialisation of public trade) led to fully dematerialised securities, which are one of the types of financial instruments sold on the regulated market. The author also identifies trends he believes could lead to the full dematerialisation of all types of securities, the abandonment of the notion of securities as a financial instrument, and the sale of such dematerialised financial instruments directly between interested parties via web portals, bypassing stock exchanges and brokerage houses.
Koncepcja metodyki projektowania i wdrażania dobrych praktyk informatycznych dla sądów powszechnych
Authors: Grabowski Mariusz , Madej Jan , Trąbka Jan
Published: December 2018

The paper presents a process for conceptualising and deploying IT (information technology) good practices formulated during the implementation of the „Education in the area of time management and cost management of judicial proceedings – case management” project (a part of Poland’s Human Capital Programme). This project was one of the components supporting the reform of the Polish judiciary and was aimed at increasing the efficiency of the judicial system by lowering costs and increasing employee skills. The paper describes all of the project phases the authors participated in their capacity as both experts and researchers. These included learning about the auto-diagnosis of 30 pilot courts, through conducting on-site visits in chosen courts, to formulating the final deployment concepts of six IT good practices implemented in a selected pool of 60 courts.
Commercialisation of Pickering Emulsions
Authors: Rodrigues Jhonny
Published: December 2018

This event, hosted by the Royal Society of Chemistry, was held at Burlington House, London, UK, on 23rd November 2017. There was a good attendance with 55 delegates from academia and industry, mainly from the UK. A brief overview of some of the presentations is described here to give a flavour of recent progress in this area.

The first session was called ‘Control of Pickering Emulsions’. Professor Bernard P. Binks (University of Hull, UK) reviewed the fundamentals of solid-stabilised emulsions with the use of inorganic silica particles, whereas Professor Steven P. Armes (University of Sheffield, UK) extended the topic with the use of polymer particles.
Innovative design of the world’s tallest electrical transmission towers
Authors: Xu Fei , Chen Ju , Guo Yong , Ye Yin
Published: December 2018

Providing a new 500 kV electricity supply to Zhoushan Islands off the east coast of China in 2018 involved building the world’s two tallest transmission towers. The 380 m typhoon-resistant towers enabled high-voltage cables to span 2·7 km over the East China Sea. To reduce wind loads, the towers were made from a tubular steel filled with steel angle-reinforced, self-compacting concrete. This paper describes the design and detailing of the innovative composite members and joints specifically developed for the project. It aims to serve as a design reference for future long-span electrical transmission towers.
The effect of the new hemostatic agent Ostene® on bone healing: An experimental study in rabbits
Authors:   Asst. lecturer. Department of Oral and Maxillofacial surgery, College of Dentistry, University of Mosul. Iraq., Naser Alyaa I.
Published: December 2018

Introduction: Ostene® is a water-soluble wax-like alkylene oxide copolymer preparation for use as a mechanical hemostatic agent. This study aims to evaluate the effects of Ostene® on bone healing. Materials and Methods: Twenty albino rabbits were divided into four groups according to post-treatment follow-up (24 hr, 3 days, 7 days, 14 days) with five rabbits in each group. Each rabbit in all groups was treated with two study materials (Ostene® and Gelfoam®). Three holes were made in the mandibular bone of each rabbit using 5mm surgical bur; two holes were made on right side: one for testing Ostene® and another for Gelfoam®. A third hole, on the left side of mandible, was not treated, and was used as a control. Finally, the incision was closed. The specimens were collected at different days post-treatment and examined by histopathology. Result and Discussion: This study showed that there is a significant difference (p-value≤ 0.05) between the Ostene® group and the other groups (Gelfoam® and control). At 24 hr post intervention, there is a significant difference in osteoblast cell formation (p-value=0.03), and osteoclast cell formation (p-value=0.05). New blood vessel formation, osteoblast and osteoclast cell formation for Ostene® group at 3 days post-intervention were also significantly different (p-values = 0.05, 0.03, 0.04, respectively). At 7 days post-intervention p-values were 0.05 for osteoblast formation and 0.04 for osteoclast formation, respectively. After 14 days of healing p-value for osteoblast cell formation in the Ostene® group was 0.05 and 0.04 for osteoclast cell formation. Conclusions: The bone hemostatic agent Ostene® is an effective at enhancing osteogenesis by initiating proliferation of osteoblast and osteoclast cells.
Política migratoria y seguridad en Argentina hoy: ¿el paradigma de derechos humanos en jaque?/ Migration policy and security in Argentina today: human rights paradigm in jeopardy?
Authors: Penchaszadeh Ana Paula , García Lila Emilse
Published: December 2018

Este artículo tiene por objetivo abordar los recientes cambios operados en la política migratoria argentina, con especial énfasis en las modificaciones introducidas por el Decreto de Necesidad y Urgencia (DNU) 70 (de enero de 2017), con vistas a iluminar los vínculos actuales entre migraciones, derechos humanos y seguridad. El caso argentino resulta de especial interés porque la Ley Migratoria vigente desde 2004 incorpora importantes estándares de derechos humanos, que deberían funcionar como límite al avance de ciertas prerrogativas soberanas del Estado en nombre la seguridad. Las distintas medidas adoptadas por el Gobierno de la alianza Cambiemos, desde su llegada al poder en 2015, se basaron en una vinculación directa entre migración y criminalidad, dirigida a reinscribir la política migratoria en el terreno de la seguridad y a enfatizar el control, en detrimento de la integración de las personas migrantes. Creemos que el DNU 70 tiene un carácter ejemplar para el análisis específico de las paradojas que entraña la criminalización de las migraciones, con el consecuente avance de la excepcionalidad soberana, en un contexto normativo de reconocimiento de los derechos humanos. Sobre estas tensiones versa el presente artículo, con la expectativa de que este caso pueda alumbrar otros similares.

Abstract

The goal of this paper is to address recent changes over Argentine migration policy, particularly reforms introduced by the Necessity and Urgency Decree (Decreto de Necesidad y Urgencia-DNU) 70, issued by the executive branch in January 2017, to highlight the current links between migrations, human rights and security. Argentina’s case is of the most importance given that its Migration Law (from 2004) has recognized the highest standards on human rights, which should limit certain actions of the State taken in the name of security. Measures adopted by Cambiemos government (a right based coalition that won in 2015) are based on a direct linkage between migration and criminality, intended to rewrite migration policy in the field of security to emphasize control, instead of social integration of migrants. In this frame, we believe DNU 70 set an example that allows analyzing the paradox encompasses in the criminalization of migrations, with consequences such as more exceptionalism in sovereignty, even though in a context of general recognition of human rights. This article goes about these tensions expecting Argentina’s case may illuminate others.
De la era de la migración al siglo de la seguridad: el surgimiento de “políticas de control con rostro (in)humano”/ From the age of migration to the century of security: the emergence of ‘control policy with a (in)human face’
Authors: Ramírez Jaques
Published: December 2018

Si bien el discurso oficial, aceptado prácticamente por todos los Estados, habla de una migración “regular, ordenada y segura”, lo cual ha quedado sellado en el Pacto Global de las Migraciones, la movilidad humana contemporánea difiere mucho del deseo de los gobernantes, tanto en el perfil como en las vías utilizadas para llegar al destino. El presente artículo pasa revista a algunos “paisajes migratorios” en varios lugares del planeta, que han tenido como correlato la respuesta estatal de mayores controles, apelando al discurso de la soberanía nacional. Se plantea la tesis de que en esta nueva etapa del neoliberalismo estamos presenciando el surgimiento de políticas de control con rostro (in)humano de carácter neofascista, sobre todo con el ascenso al poder de Gobiernos nacionalistas y de extrema derecha, que impulsan y practican la xenofobia, el racismo y la aporofobia. Esto ha resultado en un incremento de la deportación, judicialización de la migración, expulsión, confinamiento, construcción de muros, extorsiones, secuestros, desapariciones, tortura y muerte.

Abstract

Although the official discourse, accepted practically by all the States, speaks of a "regular, orderly and safe" migration, which has been sealed in the Global Compact for Migration, contemporary human mobility differs greatly from the desire of the rulers both in the profile and in the routes used to reach destination. This article reviews a number of 'migratory landscapes' in several places on the planet that have had as a correlate the State´s response to greater controls, appealing to the discourse of national sovereignty. The following thesis is proposed: that in this new stage of neoliberalism we are witnessing the emergence of control policy with an (in) human face of neo-fascist character, especially with the rise to power of nationalist and far-right governments that promote and practice xenophobia, racism and aporophobia. This has resulted in increased deportation, judicialization of migration, expulsion, confinement, construction of walls, extortion, kidnapping, disappearances, torture and death.
Análisis de las características fisicoquímicas del agua subterránea de la cuenca del río chicú, Colombia, usando indicadores hidroquímicos y estadística multivariante
Authors: López Velandia Cristian Camilo
Published: December 2018

Se evaluaron las características hidroquímicas de una cuenca intramontana, ubicada en la Sabana de Bogotá, usando indicadores y métodos estadísticos, basados en los datos fisicoquímicos de 10 pozos de monitoreo obtenidos durante dos campañas de muestreo realizadas en el año 2014, para determinar las características hidroquímicas generadas por la interacción agua/sedimento del acuífero y determinar las condiciones de calidad del agua subterránea. Para ello, (1) se aplicaron indicadores hidroquímicos para evaluar los procesos de interacción entre el agua y la matriz sedimentaria del acuífero, corroborados mediante (2) la aplicación del análisis de componentes principales, que develó asociaciones fuertes entre las variables (Na+, Mg2+, Ca2+, SO42- y HCO3-), y la influencia de las variables T, pH y STD en los procesos hidroquímicos que gobiernan el acuífero, además (3) se analizaron los parámetros fisicoquímicos, comparándolos con la normatividad ambiental colombiana para consumo humano y para riego. Como resultados, se determinó que en la matriz agua-sedimento, se suscitan procesos de intercambio catiónico reverso y meteorización de los minerales presentes en las formaciones que conforman el acuífero analizado, así mismo, que las muestras de agua obtenidas no presentan características de calidad que permita su uso para riego o consumo humano.
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report
Authors: Hardman Matthew I. , Sprung Juraj , Weingarten Toby N.
Published: December 2018

Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA)B, A, and B-phenethylamine receptors. It is prescribed in former Communist Bloc countries for anxiolysis and related psychiatric disorders. It can be easily obtained in Western countries and is thought to have abuse potential. Abrupt discontinuation has been reported to precipitate an abstinence syndrome. A review of the literature identified 22 reported cases, many of which were notable for severe psychomotor agitation and requirements for aggressive pharmacologic treatment. Neurologic and autonomic signs and symptoms may mimic serotonin or neuroleptic malignant syndrome. Patients were typically younger and had coexisting substance abuse disorders to other drugs. Also presented is a case of a 23-year-old male with an acute phenibut abstinence syndrome. This patient exhibited severe psychomotor agitation requiring physical restraints, dexmedetomidine, lorazepam, haloperidol, diphenhydramine, cyproheptadine, melatonin, olanzapine, and baclofen for symptom control.
The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis v2
Authors: M. Nunes Quentin , Su Dunhao , Thao Bui Phuong , M. Simpson Deborah , J. Brownridge Philip , Sun Changye , Li Yong , X Zhang , Huang Wei , J. Rigden Daniel , J. Beynon Robert , Sutton Robert , G. Fernig David
Published: December 2018

Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in cell communication. Therefore, we used heparin affinity proteomics to identify extracellular HBPs in pancreas and plasma of normal mice and in a caerulein mouse model of AP. Many new extracellular HBPs (360) were discovered in the pancreas, taking the total number of HBPs known to 786. Extracellular pancreas HBPs form highly interconnected protein-protein interaction networks in both normal pancreas (NP) and AP. Thus, HBPs represent an important set of extracellular proteins with significant regulatory potential in the pancreas. HBPs in NP are associated with biological functions such as molecular transport and cellular movement that underlie pancreatic homeostasis. However, in AP HBPs are associated with additional processes such as acute phase response signalling, complement activation and mitochondrial dysfunction. Plasma HBPs in AP included known AP biomarkers such as serum amyloid A, as well as emerging targets such as histone H2A. Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP. These need further investigation for potential applications in the management of AP.
THE ROLE OF ORTHOSTATIC TEST IN PROGNOSIS OF ARTERIAL HYPERTENSION DEVELOPMENT IN YOUNG ADULTS
Authors: Sklyannaya E. V.
Published: December 2018

The aimof this study was to assess the role of orthostatic test in prognosis of arterial hypertension (AH) in young adults.

Materials and methods.842 young adults 20–29 years old with the level of blood pressure (BP) <140/90 mm Hg were enrolled in a prospective study. Active orthostatic test was performed. Observation period was 5 years. After that 2 groups were assigned according to BP level: group 1 – with AH (BP level >140/90 mm Hg), group 2 – with normal BP level (<140/90 mm Hg).

Results.Physiological type of orthostatic reaction was found in 542 persons (64.4 %), primary hypersympathicotonic type – in 79 (9.4 %), secondary hypersympathicotonic – in 93 (11.1 %), hyposympathicotonic – in 94 (11.2 %), sympathicoasthenic – in 34 (4.0 %). 78 persons were withdrawn from the study for different reasons during observation period. AH was diagnosed in 144 (18.8 %) persons (group 1), normal BP – in 620 (81.2 %) participants (group 2). In group 1 hypersympathicotonic response to orthostatic test was observed in 102 (70.8 %) persons, in group 2 – in 47 (7.6 %) participants (р <0,001). By the results of univariate logistic regression analysis male sex (OR 10.8; 95 % CI 7.6–15.3), body mass index >25 kg/m2 (OR 7.2; 95 % CI 5.7–9.1), smoking (OR 5.6; 95 % CI 4.5–7.0), high normal BP (OR 10.7; 95 % CI 6.9–14.5) and hypersympathicotonic orthostatic response (OR 13.6; 95 % CI 10.0–18.7) were significant risk factors of AH. By the results of multivariate analysis body mass index >25 kg/m2, high normal BP and hypersympathicotonic orthostatic response were independent risk factors.

Conclusion.Hypersympathicotonic orthostatic response with increased body mass index and high normal BP are the risk factors of AH development during next 5 years in young adults. It is reasonable to use orthostatic test in assessing the risk of AH development in young people.
Medical rehabilitation of patients with urinary incontinence
Authors: Satybaldyev Sh. R. , Satybaldyeva E. Sh. , Evdokimov V. V.
Published: December 2018

The study objectiveis to evaluate the effectiveness of physiotherapy, therapeutic gymnastics and psychotherapy in the medical rehabilitation of patients with different types of urinary incontinence (UI).

Materials and methods.In the departments of urology of the Kyrgyz Research Institute of Balneology and Rehabilitation were treated 164 patients with UI. Patients were divided into groups depending on the type of treatment: 132 patients were included in the treated group (UI developed as a complication of prostatectomy in 90 of them, as a complication of chronic cystitis – in 42), who used drug therapy and rehabilitation complexes. In 32 patients, only traditional drug therapy was performed, they formed a comparison group.

Results.There was a significant improvement in the clinical characteristics: the severity of pain, frequent urination, UI decreased after rehabilitation treatment by 1.5–2.0 points, after traditional treatment – by 0.3–0.8 points. The average number of UI episodes decreased by 48 % compared to the baseline, the volume of urination increased by 37 %. Urination rate decreased by 55 %. The clinical effect of rehabilitation complexes was confirmed by subjective sensations recorded in the SF-36 questionnaire.

Conclusion.Complex influence (the differentiated application of physiotherapy, physiotherapy in combination with psychotherapy, electrostimulation and magnetotherapy) caused high clinical level of rehabilitation.
Peculiarities of physical and sexual development of boys in the onset of puberty in different ecologo-geographical regions of the Republic of Dagestan
Authors: Kamalov K. G. , Gazimagomedov G. A. , Magomedova I. M.
Published: December 2018

The study objectiveis to compare the characteristics of physical and sexual development of boys aged 11–13 years living in different ecological and geographical areas of the Republic of Dagestan and to determine the effect of chronic iodine deficiency on the onset of puberty.

Materials and methods. In a lowland area containing 11 districts, 501 subjects were examined; in a mountain area containing 17 districts, 325 subjects were examined; in a submontane area containing 7 districts, 274 subjects were examined. In total, 1100 boys aged 11–13 years were randomly selected.

Results.Physical development of the boys was mostly characterized as normal but with a clear tendency toward lower values, especially in the submontane districts. In boys living in the areas with severe iodine deficiency, delayed onset of puberty was observed 3.2 times more frequently than in their counterparts living in the districts with mild iodine deficiency. Total fraction of boys with signs of delayed sexual development was 38.5 %, and they mostly lived in the submontane area.

Conclusion.Emerging in Russia tendency toward lowered characteristics of physical development of boys is observed in the Republic of Dagestan. This confirms the negative effect of chronic iodine deficiency on sexual development of boys which manifests through delayed sexual maturity.
Evaluation of Sinergin antioxidant complex effectiveness in combination treatment of pyelonephritis complicated by kidney stones
Authors: Nashivochnikova N. A.
Published: December 2018

The study objective is to evaluate the effectiveness of Sinergin antioxidant complex in therapy of patients with pyelonephritis complicated  by kidney stones.

Materials and methods. The clinical group consisted of 30 patients who were undergoing antibacterial therapy and were taking 2 capsules  of Sinergin a day for 3 months. The control group consisted of 30 patients who were undergoing antibacterial therapy without Sinergin administration. The results were evaluated 3 and 6 months after the start of treatment.

Results. The values of clinical urine test normalized in 25 (83.3 %) patients of the clinical group and 21 (70 %) patients of the control group 3 months after the start of therapy. Signs of disease recurrence were detected in 3 patients (10 %) of the clinical group and 6 patients (20 %) of the control group 6 months after the start of treatment.

Conclusion. The use of Sinergin in combination antimicrobial therapy leads to a decrease in salt excretion with urine, as well as additional anti-inflammatory effect which persists after the end of antibacterial therapy.
Modern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)
Authors: Мukhin К. Yu. , Pylaeva О. A.
Published: December 2018

Lennox–Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by frequent polymorphic seizures (including tonic axial seizures), pronounced cognitive impairment, typical changes in the electroencephalogram and drug resistance. Frequency of LGS accounts for approximately 4–10 % of all childhood epilepsy. The difficulties in the diagnosis and treatment of LGS are associated with the presence of various seizures that are frequently resistant to multiple antiepileptic drugs as well as with the disease evolution with age. This review covers the main principles of LGS therapy, analyzes the most common antiepileptic drugs used in LGS, and describes clinical trials evaluating the efficacy and tolerability of antiepileptic drugs in LGS. The article contains a detailed algorithm for the treatment of LGS, based on international guidelines and expert opinions.
Análise confirmatória da escala comportamental para crianças do Pré-Escolar (PKBSpt): versão portuguesa || Confirmatory analysis of behavior scale for children in preschool (PKBSpt): Portuguese version
Authors: Gomes Rosa Maria , Pereira Anabela
Published: December 2018

Investigações recentes evidenciam a relevância do desenvolvimento de competências sociais das crianças, bem como, a necessidade de serem usados instrumentos válidos e fieis para avaliar as aptidões sociais em contextos da educação pré-escolar. O presente estudo tem como objetivo principal aferir a estrutura empírica do instrumento Escala Comportamental para Crianças em Idade Pré-Escolar (PKBSpt), que procura avaliar as aptidões sociais e problemas de comportamento na primeira infância. A amostra é constituída por 577 crianças, dos 3 aos 6 anos de idade, que frequentam a educação pré-escolar. Com a participação dos educadores aplicaram-se as subescalas Aptidões Sociais e Problemas de Comportamento, avaliadas através de escalas tipo likert de quatro pontos. Os resultados mostram que os modelos relativos às subescalas do PKBSpt apresentam um ajustamento pouco elevado, mas aceitável e índices de consistência interna adequados. Estes resultados são semelhantes e enquadram-se nos estudos desenvolvidos por outros autores com o mesmo instrumento. As implicações deste estudo apontam para a utilidade do PKBSpt no pré-escolar em Portugal e em países de Língua Portuguesa. É realçada a necessidade de se realizar mais pesquisas sobre estudos confirmatórios com outra população e diferentes países.
Parental Alienation Syndrome: A critique
Authors: Willis Brendan , O’Donohue William
Published: December 2018

Parental alienation syndrome (PAS), as defined by its creator Dr. Richard Gardner (2001), is a poorly defined, poorly researched, and controversial pseudoscientific construct arising primarily in the context of child custody disputes. The syndrome allegedly manifests as a non-rational and unjustified campaign of denigration against one parent during custody proceedings. It is purported to result from the combination of a parent’s “brainwashing” and indoctrination regarding the vilification of the target parent. Unfortunately, there is little evidence to support that parental alienation represents a scientifically valid syndrome. There is no commonly recognized or empirically supported pathogenies, course, familiar pattern, or treatment selection indicated for the proposed symptoms of PAS. Additionally, it has been consistently excluded from both DSM-V and ICD-10, representing a near global rejection by the scientific community. When used in the legal context, PAS is exceptionally dangerous as it can conceal actual cases of abuse and cause children to be remanded into the custody of an abusive parent. Furthermore, it can be used as leverage to separate children from the caregiver that they are best suited to be with solely on the accusation of the non-preferred parent that they have been “alienated.” In the interest of improving the scientific quality of custody evaluations and the safety of children, pseudoscientific theories such as parental alienation syndrome should be eliminated from the custody decision making process.
Reseña del libro: 50 Clásicos de la Psicología || Review of the book: 50 Psychology Classics
Authors: Barca-Lozano Alfonso
Published: December 2018

Se presenta una reseña de una obra sorprendente por su originalidad y muy precisa y concisa en las apreciaciones de las aportaciones más relevantes que han dado a la Psicología una serie de autores e investigadores, alguno de finales del siglo XIX, y la mayoría de medidos y finales del siglo XX. La obra, aunque publicada en inglés inicialmente en el año 2007, y reeditada en castellano en 2016, sin embargo conserva toda su frescura y sus ideas clave que el autor, Tom Butler-Bowdon, economista graduado en la Universidad de Sidney, ganador de varios premios, quiso transmitir pensando no tanto en los psicólogos y profesores sino más bien en el público en general. A través de cincuenta obras de otros tanto autores, médicos, psiquiatras y psicólogos la mayoría, se han ido desgranado cientos de ideas que el propio autor del libro va seleccionando y que abarcan algo más de un siglo, examinando algunas de las cuestiones que más interesan a las personas sobre nuestra conducta… como qué es aquello que nos motiva al actuar, qué es  lo que hace que nos sintamos y actuemos de una u otra manera, sobre cómo funcionan nuestros cerebros y cómo se crea un sentido del yo. Un repaso a las principales aportaciones de 50 autores clave de la Psicología se ofrecen como todo un repertorio de ideas, principios y leyes relevantes para tratar de entender y comprender la conducta humana.