bluuebunny/crossref_metadata_2025 huggingface dataset:
How does Mentoring Occupational Therapists Improve Intervention Fidelity in a randomised controlled trial? A Realist Evaluation
Authors: Perez Blanca De Dios , Merchan Josan , Powers Katie , Craven Kristelle , Holmes Jain , Phillips Julie , Tyerman Ruth , Radford Kate
Published: December 2023

Background: Integrating complex interventions within healthcare settings can be challenging. Mentoring can be embedded within a randomised controlled trial (RCT) to upskill and support those delivering the intervention. This study aimed to understand, from a realist perspective, how mentoring worked to support implementation fidelity for occupational therapists (OTs) delivering a vocational rehabilitation (VR) intervention within the context of an RCT.
Methods: A realist evaluation using secondary data (emails, mentoring record forms, interviews) collected as part of an RCT. Three researchers coded the data following a qualitative approach, focused on refining or refuting an initial programme theory by exploring the interactions between context, mechanisms, and outcomes. The research team met to further refine the programme theories.
Results: Data from 584 emails, 184 mentoring record forms, and 25 interviews were analysed following a realist approach. We developed a programme theory consisting of two contexts (trial set-up, ongoing mentoring), nine mechanisms (collective understanding, monitoring, timely support, positive reinforcement, reflective practice, support data completeness, facilitation strategy, shared learning experience, management of research and clinical duties), and three outcomes (improved confidence, improved fidelity, reduced contamination).
Conclusions: Offering mentoring support to OTs delivering a VR intervention as part of an RCT improves intervention fidelity and reduces the risk of contamination. It improves OTs’ understanding of the differences between their clinical and research roles and increases their confidence and competence in trial paperwork completion and identification of potential contamination issues.
Relationship between asymmetry of lumbar facet joints and direction of lumbar disc herniation in patients aged 12-21 years
Authors: Xiao Kai , Xu Jianyun , Wu Jinming , Liu Yuan , Zhong Yingjun
Published: December 2023

Background: Lumbar facet joint (FJ) asymmetry is thought to be associated with lumbar disc herniation (LDH), but the relationship between the two is unclear. In addition, the effect of vertebral FJs on LDH in adolescent patients has not been elucidated. The purpose of this study was to measure and compare the angle of lumbar FJs with computed tomography (CT) and to study the relationship between vertebral FJ asymmetry with LDH as well as herniated disc location in adolescent patients (12-21 years old).
Methods: This study retrospectively analysed clinical data from the Department of Orthopaedics at The First Affiliated Hospital of Nanchang University. 149 patients with single- or two-segment LDH composed the case group and 108 adolescent patients with acute abdomen composed the control group aged 12 to 21 years diagnosed from December 2016 to December 2022. The facet joint angle (FJA) of the study subjects at the L3~4, L4~5, and L5~S1 levels was measured lumbar or abdominal CT and recorded. Facet tropism (FT) was defined as a bilateral FJA difference >7°.
Results: Among 149 patients with LDH, 57, 77, and 85 patients had FT at the L3-4, L4-5, and L5-S1 segments, while among the 108 patients without LDH (N-LDH), 25, 29, and 27 patients had FT at the L3-4, L4-5, and L5-S1 segments, respectively. The probability of FT was significantly higher in the experimental group than in the control group (P < 0.05). In the LDH group, FT was present in 31 of 51 protrusions in the L4-5 segment and 56 of 97 protrusions in the L5-S1 segment; while in the N-LDH group, 29 and 27 patients had FT at the L4-5 and L5-S1 segments, respectively. The probability of FT in the experimental group was significantly higher than that in the control group (P< 0.05). In the LDH group, among the 51 cases of L4-5 LDH, there were 18 cases of the central type, 33 cases of the paracentral type, 9 cases of the central type with FT, and 22 cases of the paracentral type with FT. Among the 97 cases of L5-S1 LDH, there were 39 cases of the central type, 58 cases of the paracentral type, 11 cases of the central type with FT, and 45 cases of the paracentral type with FT. By cardinal empirical comparison, vertebral subtotal joint asymmetry was correlated with the location of LDH in the L5-S1 segment (P < 0.05).
Conclusion: FJ asymmetry was significantly associated with LDH in the L4-5 and L5-S1 segments in adolescents, and FJ asymmetry was associated with the location of LDH in the L5-S1 segment in adolescents.
A coordination-connected flexible-rigid hybrid nanoparticles coating for the interfacial enhancement of carbon fiber/polyetheretherketone composites
Authors: Jiang Naiyu , Li Yingze , Zhou Nan , Zhang Hongyan , Zou Xiaohu , Zhang Dongxing
Published: December 2023

To date, carbon fiber (CF) reinforced polymer composites have found widespread application due to exceptional properties, including high specific strength and modulus, thermal stability, chemical durability. However, the interface serves as the bridge for load transfer between fiber and resin, the interfacial property directly affects the holistic performance of the composites. Therefore, considering the inertness of CF and polyetheretherketone (PEEK), and the modulus gap between them, we propose a flexible-rigid sizing agent for enhancing the interfacial adhesion and mechanical properties of CF/PEEK composites. The sizing layers are constructed by the hybrid nanoparticles of rare-earth coordination bonded flexible aramid nanofiber (ANF) and rigid nano-TiO2, and the transition layer of polyetherimide (PEI). The treatment with the flexible-rigid sizing agent significantly improves the active functional group content, surface roughness, and wettability of the CF. Meanwhile, as-prepared CF/PEEK composites show a remarkable enhancement both in mechanical and interfacial strength, which could be attributed to the synergistic effects of flexible-rigid structures, ultimately improve the external stress transfer and suppression of crack propagation. Herein, this work offers a robust and promising approach for the fabrication of high-performance CF/PEEK composites.
Factors affecting upper arm exercise self-efficacy in cancer patients with PICC: A cross-sectional study
Authors: Xiang Xuan , Whang You Fang , Zhang Yue Qi , Pan Meng
Published: December 2023

Aims and Objectives: This study investigated the level of upper arm exercise self-efficacy in cancer patients with PICC and explored factors that may influence upper arm exercise self-efficacy.
Background: Exercise self-efficacy predicts exercise behavior and is related to individual exercise adherence. Upper Arm exercise is safe and effective in preventing Catheter-related complications while maintaining the ability to perform activities of daily living in cancer patients with PICC. However, there is a lack of research on upper-arm exercise self-efficacy and the factors influencing the exercise self-efficacy of cancer patients with PICC.
Setting:Cross-sectional survey using a correlational design.
Methods:The study included cancer patients with PICC who attended three tertiary hospitals in Guangzhou City from June to September 2023. Data were collected using a general information questionnaire, the Upper Arm Exercise Self-Efficacy Scale for Cancer Patients with PICC , the Cancer Patients PICC Self-Management Competency Scale, the Perceived Social Support Scale, and the Hospital Anxiety and Depression Scale, and multiple linear regression analyses were used to evaluate the factors associated with the level of upper arm exercise self-efficacy.
Results: The mean upper arm exercise self-efficacy score for cancer patients with PICC was 82.33±15.80, and the overall score was 71.16%, which is in the middle range. The main factors affecting upper arm exercise self-efficacy in cancer patients with PICC included depression (β= -0.447, p<0.001), exercise before illness (β= 0.158, p<0.001), PICC self-management competency(β= 0.169, p<0.001), perceived social support (β= 0.169, p<0.001), per capita monthly household income (β= 0.081, p = 0.002), PICC catheter retention time (β= -0.053, p=0.042), primary caregiver (β = -0.050, p = 0.024).
Conclusions: The level of upper arm exercise self-efficacy in cancer patients with PICC needs to be further improved. Clinical healthcare professionals can consider the factors affecting the self-efficacy of upper arm exercise in cancer patients with PICC , formulate a targeted exercise intervention programme, and carry out follow-up visits in a planned manner to guide, supervise, and strengthen the level of self-efficacy of upper arm exercise, and ultimately to achieve the goal of health promotion.
Relevance to clinical practice: This study proposes that upper arm exercise self-efficacy behaviors should be promoted in cancer patients with PICC. In response to the identified influencing factors, further upper arm exercise promotion programs are recommended to improve their exercise compliance.
Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells
Authors: Mancini Rita , Ascenzi Francesca , Esposito Antonella , Bruschini Sara , Salvati Valentina , De Vitis Claudia , Ricci Giulia , Martino Simona Di , Buglioni Simonetta , Bassi Massimiliano , Venuta Federico , De Nicola Francesca , Massacci Alice , Grassucci Isabella , Pallocca Matteo , Ricci Alberto , Fanciulli Maurizio , Ciliberto Gennaro
Published: December 2023

Scientific literature supports the evidence that Cancer Stem Cells (CSCs) retain inside low Reactive Oxygen Species (ROS) levels and are therefore less susceptible to cell death, including ferroptosis, a type of cell death dependent on iron-driven lipid peroxidation. A collection of lung adenocarcinoma (LUAD) primary cell lines derived from malignant pleural effusions (MPEs) of patients was used to obtain 3D spheroids enriched for stem-like properties. We observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in LUAD cells when grown in 2D conditions; however, when grown in 3D condition, all cell lines underwent a phenotypic switch, exhibiting substantial resistance to RSL3 and therefore protection against ferroptotic cell death. Interestingly, this phenomenon was reversed by disrupting 3D cells and growing them back in adherence, supporting the idea of CSCs plasticity, which holds that cancer cells have the dynamic ability to transition between a CSC state and a non-CSC state. Molecular analyses showed that ferroptosis resistance in 3D spheroids correlated with an increased expression of antioxidant genes and high levels of proteins involved in iron storage and export, indicating protection against oxidative stress and low availability of iron for the initiation of ferroptosis. Moreover, transcriptomic analyses highlighted a novel subset of genes commonly modulated in 3D spheroids and potentially capable of driving ferroptosis protection in LUAD CSCs, thus allowing to better understand the mechanisms of CSC-mediated drug resistance in tumors.
Analysis of ground motion intensity measures for records of the 2023 Turkey-Syria earthquake
Authors: Erazo Kalil
Published: December 2023

Ground motion intensity measures (GMIM) provide a quantitative metric of the strength of a ground motion with the goal of providing a mapping to the potential damaging effects induced by earthquakes. The potential correlation between GMIM and earthquake damage allows their use in earthquake engineering applications such as (pre-event) seismic hazard/risk assessment and mitigation, and (post-event) damage assessment and resources allocation for disasters response. GMIM are also used for damage prediction in the context of performance-based earthquake engineering and earthquake-resistant design. This paper presents the evaluation of GMIM using strong motion records obtained during the 2023 Turkey-Syria earthquake. The GMIM studied include peak ground acceleration, peak ground velocity, spectral accelerations, root-mean-square acceleration, Arias intensity, cumulative absolute velocity, Housner spectral intensity, and Araya-Saragoni intensity. The GMIM are evaluated at several spatial locations where ground motion records were measured during the events. Examination of the results show that some of the GMIM showed particularly high values at locations where severe damage was observed after the earthquake. It is also shown that the maximum considered earthquake (MCE) spectra was exceeded at several locations where extensive damage was observed.
Urea-based Fuel Cells on Paper with Micro-Watt Power Generationto Drive Low Power Circuits
Authors: Krishna Sai , Lal Sweta , Shrivastava Suyash , Bahubalindruni Pydi Ganga
Published: December 2023

This work demonstrates the application of a urea-powered paper-based fuel cell (PFC) with Hydrogen Peroxide (H2O2) as the oxidant to drive a flexible electronic circuit (ring oscillator (RO)), for the first time. Herein, the electrochemical performance of membraneless PFCs is studied by employing different non-precious electrodes, such as, Nickel-mesh, Toray carbon paper(CP) and Nickel Cobalt nanoparticles supported on reduced Graphene Oxide loaded on the CP (NiCo@rGo@CP). A single-PFC with Ni-Co@rGo@CP as electrodes delivers a peak power density (Pmax) of 55 µW cm− 2, maximum current density (Jmax) of 371 µA cm− 2 and an open-circuit voltage (OCV) of 0.7 V at 3 M urea. A membrane-based PFC assembled onto an anion exchange membrane with Ni-Co@rGo@CP electrodes, delivers a Pmax of approx 70 µW cm− 2, Jmax of ≈ 500 µA cm− 2 and an OCV of 0.7 V at 3 M urea. Subsequently, a stack of two membrane-based PFCs delivers an OCV of ≈ 1.4 V for 400 seconds. Finally, this stack is employed as a power source to drive a RO. The measured frequency and peak-to-peak voltage are 37.52 kHz and 1.04 V, respectively. This demonstration opens a window to implement self-contained flexible electronic system using PFC as power source with minimal e-waste.
Exosomal miRNA-92a Derived from Cancer-Associated Fibroblasts Promote Invasion and Metastasis in Breast Cancer by Regulating G3BP2
Authors: sheng zhimei , Wang Xuejie , Zheng Yuanhang , Duan Wanli , Dong Hao , Zhang Hongxing , Cui Meimei , zhang baogang
Published: December 2023

Cancer-associated Fibroblasts (CAFs) exert a tumor-promoting effect in various cancers, including breast cancer. CAFs secrete exosomes containing miRNA and proteins, influencing the tumor microenvironment. In this study, we identified CAF-derived exosomes that transport functional miR-92a from CAFs to tumor cells, thereby intensifying the aggressiveness of breast cancer. CAFs downregulate the expression of G3BP2 in breast cancer cells, and a significant elevation in miR-92a levels in CAF-derived exosomes was observed. Both in vitro and in vivo experiments demonstrate that miR-92a enhances breast cancer cell migration and invasion by directly targeting G3BP2, functioning as a tumor-promoting miRNA. We validated that the RNA-binding proteins SNRPA facilitate the transfer of CAF-derived exosomal miR-92a to breast cancer cells. The reduction of G3BP2 protein by CAF-derived exosomes releases TWIST1 into the nucleus, promoting epithelial-mesenchymal transition (EMT) and further exacerbating breast cancer progression. Moreover, CAF-derived exosomal miR-92a induces tumor invasion and metastasis in mice. Overall, our study reveals that CAF-derived exosomal miR-92a serves as a promoter in the migration and invasion of breast cancer cells by reducing G3BP2 and may represent a potential novel tumor marker for breast cancer.
Status and availability of physiotherapy in Nepal as reported from facilities and official registers
Authors: Shakya Nishchal Ratna , Shrestha Nistha , Webb Gillian , Myezwa Hellen , Karmacharya Biraj Man , Stensdotter Ann-Katrin
Published: December 2023

Background
Physiotherapy is a growing profession in Nepal, but there are challenges in providing equitable access and availability to physiotherapy services, particularly in underserved areas. There have been several efforts to promote physiotherapy services, however there is still a need to develop and strengthen physiotherapy and its services. Updated information and proper planning for resource allocation are important for addressing these challenges.
Objective
This study aimed to explore the status and availability of physiotherapy in Province 3 of Nepal.
Method
Data was collected through a cross-sectional survey of health facilities in the province using stratified purposive sampling. The eligible facilities were selected from the list of Department of Health Services. The survey contained closed-ended questions addressing primarily physiotherapy services in the outpatient department, human resources, charging and record-keeping systems, and accessibility. Visits to governing institutions and reviews of register data and reports were performed to obtain national physiotherapy data.
Results
The survey included 25 urban and 4 rural facilities, including hospitals and rehabilitation centres; both public (37.9%) and non-public (62.1%). Most facilities (79.3%) employed physiotherapists with bachelor's degrees. On average, there were 29.55 physiotherapy outpatients and 14.17 inpatients per day. Patient records were mainly paper based, with most (69%) using the hospital main card for patient case documentation, while others (31%) had their own physiotherapy assessment card. The majority of referrals came from doctors in different departments. The most commonly offered services were musculoskeletal, neurological, and paediatric physiotherapy. The average charge for a single visit was 311 Nepalese rupees ≈ 2.33 US$, and daily basis charging was common. Accessibility for patients with disabilities was reported as partial by 79% of outpatient departments. Two centres did not have disability-friendly settings, and only one had a disability-friendly toilet.
Conclusion
Overall, the study highlights the significant variations in physiotherapy services and the need for proper planning. The finding emphasizes the need for a proper data registry to inform resource allocation, as well as the need for monitoring services and further research on physiotherapy provision, particularly in underserved areas.
Stochastic two-scale convergence in the mean in Orlicz-Sobolev’s spaces and applications to the homogenization of an integral func- tional
Authors: Tchinda Franck , Tachago Joel Fotso , Dongho Joseph
Published: December 2023

In this paper, we study the stochastic homogenization for a family of functionals with convex and nonstandard growth integrands defined on Orlicz-Sobolev’s spaces. One fundamental in this topic is to extend the classical compactness results of the two-scale convergence method in the mean to this type of spaces. This problematic relies on the notion of dynamical system which is our basic tool. Mathematics Subject Classification (2010). 35B27, 35B40, 37A05, 37A55.
Orbicularis oris and buccinator as a sphincter complex of the oral fissure – re-evaluation using isolated muscle specimens.
Authors: Ishii Masuko , Kato Kota , Ichimura Koichiro , Sakai Tatsuo
Published: December 2023

Purpose This study aimed to clarify the structural arrangement of the orbicularis oris (OOr), the buccinator (BC), and the other perioral muscles around the modiolus. Methods The perioral muscles in seventeen faces were dissected in situ and/or in isolated muscle specimens, and their layers were reconstructed schematically upon pantomographic view of the skeleton to evaluate their actions. Results The BC was composed of three parts including upper and lower oblique parts (BC-UO, BC-LO) in its superficial layer and a middle transverse part (BC-MT) in its deep layer. The superior and inferior OOr (SOOr and IOOr, respectively) were composed of an inner marginal part (SOOr-IM, IOOr-IM) and an outer labial part (SOOr-OL, IOOr-OL) in each. The perioral muscles as a whole were arranged in three layers. The first layer, with the depressor anguli oris (DAO) connected at the modiolus with the SOOr-OL, could mainly depress and deform the upper lip, as well as move the modiolus medially, upward, or downward. The second layer, with the BC-UO and the BC-LO connected at the modiolus with the IOOr-OL, could mainly elevate and deform the lower lip, as well as move the modiolus medially or laterally. The third layer, with the BC-MT continuous with the SOOr-IM, IOOr-IM, and IOOr-OL, could bring the upper and lower lip margins nearer to close the oral fissure lightly. Conclusions The actions of the individual perioral muscles on the movement of lips were predicted to open and close the oral fissure, and widen and narrow the lip width.
Private Practitioner Characteristics and Their Potential to Contribute to Tuberculosis Management in Indonesia
Authors: Alisjahbana Bachti , Sujatmiko Budi , Afifah Nur , Dewi Nury Fitria , Lestari Bony Wiem , Hadisoemarto Panji Fortuna , McAllister Susan , Hill Philip C
Published: December 2023

Background
Many tuberculosis (TB) patients first seek care through the private health sector; however, most private practitioners (PPs) are not linked to the National TB Program (NTP). We aimed to map, characterize, and assess the potential contribution of PPs to the Indonesian NTP, particularly for TB diagnosis and care.
Methods
This study was conducted between August 2017 and April 2018 in Bandung city, West Java, Indonesia. Trained enumerators surveyed 30 (of 73) randomly selected community health centers (CHCs) to identify the location of private health care facilities (HCFs) and recorded service characteristics, including physician’s qualifications and practice schedules. We also asked whether the PPs were managing patients with respiratory tract infection (RTI), ordering a TB diagnosis in the past three months, or treating TB patients at the time of interview.
Results
Among the 936 practicing PPs, 27 (IQR: 12–40) were distributed widely per CHC area. We successfully interviewed 674 (72.0%) PPs, 88.1% (594/674) of whom reported managing patients with RTI symptoms. Most PPs were administered in clinics with multiple providers (78.6%; 530/674), and 21.4% (n = 144) of the PPs were administered in a single-provider clinic. A small proportion of PPs practiced in HCFs were equipped with an X-ray (10.1%) or laboratory (27.1%) facility, and 23.2% collaborated with the national health insurance system. Almost three-quarters (70.0%) practiced in an HCF with a pharmacy. A third (33.3%; 209/627) provided services after weekday office hours, and 28.3% (191/674) offered weekday and weekend clinics. Of the PPs managing RTI patients, 241 (40.6%) reported encountering TB patients, and 101 (17.0%) had TB patients under their treatment program at the time of the interview. Overall, they self-reported that 937 patients were diagnosed with TB in the past three months and that 354 TB patients were receiving treatment.
Conclusions
PPs have great potential to contribute to TB care because they are present in large numbers, are well distributed in all CHC areas, and can provide services after regular office hours. Some PPs even worked in HCFs supported by X-rays, laboratories, and pharmacies. We should seek ways to engage PPs optimally with the NTP.
Assessing the Exchange-rate pass-through to inflation in Burundi:
A RE -EXAMINATION
Authors: Irumva Ghislain
Published: December 2023

This study assesses the empirical determinants of inflation in Burundi over the period from January 2007 to July 2022. A single error correction model is used in which the underlying determinants of the food and non-food components of inflation as well as structural factors are incorporated into the headline inflation equation. The major contribution to the existing literature is the study of the role of the tax sector in modeling inflation, an aspect that has been neglected in existing studies on inflation in Burundi.
The empirical results reveal that the long-term sources of headline inflation are determined in the external sector market, where the exchange rate premium, world food and non-food prices determine the domestic prices as well as in the fiscal sector. In the short term, exchange rate movements, energy price adjustments, imported non-food inflation and changes in money growth as well as public sector borrowing influence headline inflation where public sector borrowing plays an important role in inflationary pressures.
Three conclusions can be drawn from these empirical results: First, the dominant influence of the exchange rate on headline inflation and its sub-components deserves special attention from the authorities, who must take consistent measures to curb the depreciation excessive BIF against the US dollar. Second, with regard to the pass-through of imported inflation, expanding and diversifying the manufacturing base to limit the current heavy reliance on imports of manufactured goods and capital goods remains a policy priority. Finally, the role of supply shocks, evident in the impact of food prices on inflation, requires immediate and significant reforms in the agricultural sector to boost productivity through the use of modern production methods.
JEL: E31, 055, C22, E62
Formalization of decision-making procedures regarding the extension of the operation term of railway rolling stock in the conditions of post-war development of Ukraine
Authors: Holub Halyna , Haidenko Oles
Published: December 2023

Summary: Today, the vast majority of the railway transport fleet in Ukraine has reached the end of its service life, set by the manufacturer. One of the ways to solve the problem of aging rolling stock, along with the purchase of new wagons and locomotives, remains the extension of the service life of passenger wagons due to the restoration of their resource during appropriate repairs. However, the extension of the service life of rolling stock in Ukraine is regulated by a large number of documents (more than a dozen). Since information is scattered in various sources, the need to consider many criteria regarding the possibility of extending the service life of various types of railway rolling stock units creates certain difficulties in perceiving information and takes time to make a decision on the appointment of the necessary type of repair. One of the solutions to the problem of decentralization of the regulatory framework, along with its change, is its formalization for further development of automated decision-making systems in this area. The paper proposes the classification of passenger wagons of locomotive traction (as the most difficult case) by type and place of production from the point of view of the issue of continuing operation beyond the period established by the manufacturer. An algorithm has been developed for the exact calculation of the difference between dates (construction, repair history, and the maximum period of operation), ensuring compliance with regulatory documents, and based on it, software that allows to determine the existence of grounds for extending the term as quickly as possible in the conditions of technical diagnostics using a smartphone operation of the load-bearing structures of locomotive traction passenger wagons and calculate the type of repair that must be scheduled according to the calendar period
Socio-cyber-physical systems’ threats classifier
Authors: Milevskyi Stanislav , Korchenko Oleksandr , Yevseiev Serhii
Published: December 2023

Summary: The article considers a new approach to the formation of a threat classifier in socio-cyber-physical systems. These systems, as a rule, are complex and based on the synthesis of cyber-physical components using smart technologies and social networks. It is important to note that these systems also belong to critical infrastructure objects, which requires a new approach to the creation of multi-contour security systems. An important task for the formation of the security contour of such systems is the development of a threat classifier that allows to objectively assess the criticality of the organization's infrastructure elements. The presented classifier allows to define an expert approach at the initial stage for establishing weighting factors of the influence of threats, such as anomalies, deviations from normal functioning and computer incidents. At the next stage, the characteristics of the impact of threats on the platforms of socio-cyber-physical systems, as well as their impact on the external and internal aspects of the system, are determined. The influence of social engineering methods, which can significantly increase the risk of threat implementation and create various channels for their implementation, including mixed (targeted) attacks, is considered in detail. On the basis of the proposed approach to the classification of threats, a method of assessing the current state of the level of security of socio-cyber-physical systems and the possibilities of determining the critical points of the system infrastructure is proposed. Countermeasures and the ability of multi-loop security systems to provide effective infrastructure protection are also discussed
Investigation of the influence of an intermediate adapter on the dynamic load of a supporting structure of a platform wagon
Authors: Lovska Alyona , Dizo Jan , Rybin Andrij
Published: December 2023

Summary: This article is focused on a presentation of the results of the theoretical justification of the use of an intermediate adapter placed between the main supporting structure of a platform wagon and the cargo. Such a decision will contribute to reducing the vertical load of both the supporting structure of a platform wagon and ensuring the safety of the cargo transported on it. The mathematical modelling of the vertical load of a platform wagon supporting structure when moving along the joint unevenness of the track was carried out to substantiate the use of the designed intermediate adapter. In this regard, a corresponding mathematical model was created. There is taken into account an oscillating system consisting of four bodies: the platform wagon supporting structure, two bogies (the 18–100 model) and the cargo. At the same time, the cargo is considered up to the full carrying capacity of the platform wagon. The track is considered elastic-viscous. The mathematical model was solved in the MathCad software. The initial conditions (displacement and velocities) are set to be close to zero. The results of the solution established that the accelerations acting on the platform wagon supporting structure are reduced by 8.4 % compared to those acting on the typical structure without the designed intermediate adapter. The acceleration acting on the cargo placed on the platform wagon frame is 11.9 % lower in comparison with the standard load perception scheme.

The strength analysis of the adapter was calculated considering the determined values of the accelerations. At the same time, the finite element method was used for the strength analysis of the adapter in the SolidWorks Simulation software. It was determined that the calculated maximum stresses in the adapter structure are 4.1 % lower than permissible stress values. Therefore, the strength condition of the adapter is met. The performed research will contribute to a creation of developments in the design of modern designs of railway vehicles
Development of digital twin ecosystem and ontology in medicine
Authors: Mammadova Masuma Huseyn , Ahmadova Aytan Adil
Published: December 2023

Summary: Providing citizens with high-quality and safe medical services, providing information support for medical research and continuous medical education, making both doctor’s decisions and management decisions necessitated the provision of tools to ensure complex digitization of healthcare. To achieve these goals, a wide range of modern technologies have emerged. One such technology is digital twin technology.

Modern medicine, being formed in the environment of Health 4.0, includes not only the treatment of patients, but also the management of healthcare, the prevention of diseases and the processes of health restoration. With the increasing popularity of information communication technologies, people’s demand for health services is shifting from offline service to new online models. Currently, the field of online medicine is not developed enough to serve the elderly, chronically ill people and the people with infectious diseases. Using the advantages of digital twins in solving these problems can give positive results.

The article describes the nature, capabilities and applications of digital twin technology. The principles of the formation of the medical digital twin ecosystem are developed to ensure citizens’ accessibility to medical services and to make both medical and managerial decisions. The architecture and structural components of the digital twin ecosystem providing the connection between physical medical objects (patient, hospital, doctor, etc.) and their virtual images are shown. An ontological model for the staged construction and functionalization of the general DT of healthcare is proposed and its hierarchical architecture is established
Development and analysis of computer vision system for micromechanics
Authors: Baydyk Tetyana , Kussul Ernst
Published: December 2023

Summary: In micromechanics the best technologies are MicroElectroMechanical Systems (MEMS) and MicroEquipment Technology (MET). The MEMS used the electronic technology to produce mechanical components. Due to the advantages of the MET such as the development of low-cost micro devices, the possibility of using various manufacturing materials, the possibility of producing three-dimensional microcomponents it will be very useful to automatize all processes of mechanics production and develop different technological innovations. The automation and robotics are two closely related technologies since automation can be defined as a technology that is related to the use of mechanical-electrical systems based on computers for the operation and control of production. The field of micromechanics has been involved in different applications that cover almost all areas of science and technology, an example of this is the management of microdevices for the autofocus of digital cameras whose objective is image processing (recognizing and locate objects). The use of computer vision systems can help to automate the work of MEMS and MET systems, so the study of image processing using a computer is very important. The objective was to design a computer vision system that allows the movement of the lens to focus the work area, for the monitoring of the micromachine tool in manufacturing processes and assembly of microcomponents in real time using previously developed image recognition algorithms. The developed algorithms use the criterion of improving the contrast of the input image. We describe our approach and obtained results. This approach can be used not only in micromechanics but in nanomechanics too
BURSA YENİŞEHİR MEVLEVÎHÂNESİ
Authors: ÖCALAN Hasan Basri
Published: December 2023

Osmanlı tasavvuf tarihi konusunda en önemli kaynaklardan biri de arşiv belgeleridir. Merkezden taşraya veya taşradan merkeze yazılan resmî yazışmaların kayıtları, tahrir defterleri, vakfiyeler, şer’iye sicilleri gibi belgeler bu konuda önemli bilgiler sunmaktadır. Nitekim Yenişehir Mevlevîhânesinin tarihçesi Osmanlı Arşiv belgelerine dayanmaktadır. Osmanlı Dönemi tasavvuf araştırmalarının özellikle şehri balı çalşımaların mutlaka arşiv belgeleri ile desteklenmesi büyük ehemmiyet arz etmektedir. Bursa’ya bağlı Yenişehir’deki Mevlevîhânesi hakkında şimdiye kadar akademik bir çalışma yapılmamıştır. Mevlevîlik tarihi konusunda yapılan çalışmalarda mevlevîhânenin varlığından sadece ismen bahsedilmektedir. Makalede Cumhurbaşkanlığı Devlet Arşivleri Başkanlığındaki bazı belgelerden hareketle konunun izi sürülmüş Yenişehir-i Fener Mevlevîhânesinin harap olmasından dolayı enkazının ve arsasının satılarak bedelen Osmanlı topraklarında yeni bir mevlevîhânenin inşa edilmesi kararı üzerine Yenişehir’de Şemaki ailesi tarafından bir Mevlevî dergâhı inşa edildiği, ancak zamanla harap olduğu tespit edilmiştir. Yazışmalara göre mevlevîhânenin yeniden yapılması kararlaştırılmış, fakat masrafların fazla olmasından dolayı vazgeçilerek Bilecik’te Hamidiye Melevîhanesi yapılmasına karar verilmiştir.
Festas escolares em Brasília
Authors: Anjos Juarez José Tuchinski dos , Ribeiro Betânia de Oliveira Laterza , Sá Elizabeth
Published: December 2023

O artigo adentra o universo de temas escolares abordados pela jornalista Yvonne Jean no jornal Correio Braziliense. O objetivo é analisar algumas festas escolares em Brasília, conforme foram descritas e comentadas em colunas da jornalista entre os anos de 1962 e 1968. Foram identificados dois tipos de festas escolares: 1) as que celebravam personagens da escola e da família − professoras, crianças e mães; e 2) as que comemoravam tradições da cultura brasileira (festas juninas). O valor histórico-educacional dos textos de Yvonne Jean se evidencia à medida que se faz deles uma leitura histórica, fundada na contextualização das fontes e em sua leitura analítico-interpretativa. É dessa leitura que tende a advir a compreensão da educação segundo a lógica das normas e práticas (Julia, 2001), das estratégias e táticas (Certeau, 1999), dos comportamentos e das apropriações (Chartier, 2002), seja de professores, seja de alunos e demais indivíduos que atuam no processo educacional intraescolar.
ENTREVISTA COM EDWARD LOPES
Authors: Diniz Maria Lúcia Vissotto Paiva , Portela Jean Cristtus
Published: December 2023

Entrevista com Edward Lopes ao então Grupo de Estudos Semióticos em Comunicação (GESCom), da Unesp de Bauru para integrar o projeto “Greimas no Brasil”, voltado à reconstrução da história da semiótica brasileira a partir da perspectiva da primeira geração de semioticistas do Brasil sobre a vinda de Greimas ao país em 1973 e a sua atuação como ministrante do curso “Semiótica da narrativa”, a fundação do Centro de Estudos Semióticos “A. J. Greimas” (CESAJG) e da revista Significação, e o papel desses pesquisadores na divulgação das obras greimasianas mediante tradução de seus escritos. A conversa com Lopes revela o percurso acadêmico que o levou a conhecer Greimas e trazê-lo ao Brasil, bem como aspectos concernentes à atuação do entrevistado como professor, pesquisador, fundador de programa de pós-graduação e autor de obras que contribuíram para o estabelecimento dessa disciplina em território brasileiro.
New Functionalized Morpholinothiazole Derivatives: Regioselective Synthesis,
Computational Studies, Anticancer Activity Evaluation, and Molecular Docking Studies
Authors: Assiri Mohammed A. , Ali Tarik E. , Alqahtani Maha N. , Shaaban Ibrahim A. , Shati Ali A. , Alfaifi Mohammad Y. , Elbehairi Serag E.I.
Published: December 2023

A new series of skeletons 2-(morpholinoimino)-4,5-disubstituted-3-
phenylthiazoles (2-15) was synthesized. The methodology involved the reactions of 1-
morpholino-3-phenyl-thiourea (1) with a variety of α-halocarbonyl compounds under
Hantzsch reaction conditions. The reaction mechanism for some postulated routes was modeled
using quantum mechanical calculations in order to investigate the regioselectivity preference
of this reaction in terms of thermodynamics. The quantum mechanical computations
compiled with experimental IR, 1H- and 13C-NMR spectral analysis supported the favorable
product, which has a thiazole ring bearing the morpholinoimino moiety at position C−2. All
synthesized products were screened using the sulforhodamine B (SRB) assay for their cytotoxic
properties against various cancer cell lines. Fortunately, the target compounds 2, 4, 5,
6, 11, and 12 were discovered to be comparable to doxorubicin in terms of their potency against all evaluated
cell lines. Utilizing flow cytometry, apoptosis and cell cycle analyses were determined and supported by molecular
docking studies. All tumor cells were significantly early- and late-apoptotic affected by the products 2, 4, 5,
6, 11 and 12, and these products also significantly halted all studied types of cancer cells in both S and G2 phases.
The discovered compounds 2 and 12 were then subjected to a molecular docking experiment to examine how
they bind with the VEGFR-2-KDR receptor.
Papua Special Autonomy in Engagement With Gender, Generations and Deforestation: Insight From Feminist Political Ecology
Authors: Manoby Worry Mambusy , Siscawati Mia , Dewi Kurniawati Hastuti
Published: December 2023

Forest governance within the framework of Special Autonomy in Papua is about improving the welfare of the Papuan people for indigenous communities. The conversion of customary forests into monoculture plantations is the main problem causing deforestation in Papua. In the patrilineal structure and patriarchal culture inherent in Papua, women only have forest management rights, while ownership rights are in the hands of men, and women will feel the impact more heavily than men when environmental degradation continues. Women's limitations in customary construction limit access and control over resources, experience vulnerability, are displaced from their living space and lose their source of livelihood. On the other hand, young people in Papua, as key actors in the process of economic and social change in Papua, have not been widely explored regarding their aspirations and role in forest governance. This study explores various academic literature and grey literature in the form of institutional work reports on forest governance in Papua with feminist political ecology focusing on the situation of gender, generations and young people, deforestation and forest governance in Papua. This study found that indigenous women and young people as part of indigenous communities are still often not considered and excluded from discussion spaces that determine the future of forest governance in Papua. Special Autonomy as respect, recognition and protection for the Papuan people. In the future, it is hoped that this can be a way to overcome injustice and inequality in the management of natural resources experienced by the people in Papua.
Shared Coordinates: Writing Herstory in Ibero American Comics
Authors: Tonfoni Virginia
Published: December 2023

This study focuses on the emergence of a transnational sisterhood under three projects originating from the cooperation between groups of female comic book writers in Spain and Latin America. After the 2016 exhibition “Presentes: Autoras de Tebeo de Ayer y de Hoy” and the publication of its catalogue by Autoras de Cómic, there was a shared need to claim back the role of female or non-male authorship, and its involvement in comic book production and business. The Argentinian group Feminismo Gráfico tapped into such endeavors, and in 2019 produced “Nosotras Contamos”, a travelling exhibition and a catalogue, with a thematic and a diachronic approach. When COVID-19 broke out, Spanish and Argentinian cooperation and development institutions (Agencia Española de Cooperación Internacional y Desarrollo and Centro Cultural España Córdoba) engaged in a discussion on the previous experiences. The project resulted in a publication and an online exhibition Coordenadas Gráficas (Graphic Coordinates), highlighting the work of non-male authors from Spain, Argentina, Chile, and Costa Rica. The transnational perspective of this last project extends beyond the previous national experiences and includes a meaningful selection of comic stories that, regardless of the nationality of the author, can be defined as feminist. Sexism, gender discrimination, gender violence, and sexual and reproductive rights are the shared coordinates discussed by this long list of authors, who question gender normativity from its very composition. By introducing the associative experiences that gave life to the projects and analyzing them in the international context, the study will focus on the appropriate practice of sharing knowledge to pursue a similar recognition. Moreover, based on the words of the curators and the creators, the study ultimately seeks to shed light on the production and circulation of works of collective interest, meant to recover the role of women in the history of comics.
Análise Transversal da Antologia Ibero-Americana Coordenadas Gráficas: Cuarenta Historietas de Autoras de España, Argentina, Chile y Costa Rica
Authors: Moriano Beatriz , Lagunas Neus
Published: December 2023

Esta recensão tem como objeto de análise a antologia ibero-americana Coordenadas Gráficas: Cuarenta Historietas de Autoras de España, Argentina, Chile y Costa Rica (Coordenadas Gráficas: Quarenta Bandas Desenhadas de Autoras de Espanha, Argentina, Chile e Costa Rica), publicada em 2020, em acesso digital aberto, por uma equipa de curadoras, no âmbito do programa Ventana da Agência Espanhola de Cooperação Internacional para o Desenvolvimento. Nela, apresentamos as principais características destas bandas desenhadas, assim como os artigos que introduzem os quatro blocos, examinamos a sua organização e os seus componentes temáticos, estilísticos e ideológicos através dum percurso definido pelos trabalhos selecionados. Destacamos a sua visão panorâmica sobre a produção historietista feminina desde as últimas décadas até o presente e a sua contribuição para visibilizar as problemáticas que, ao longo de 40 anos, as diversas autoras têm enfrentado. Ainda que esta obra apresente uma divisão nacional e, consequentemente, centrada em cada um dos seus contextos, cada secção oferece uma perspetiva interseccional e intergeracional. Definitivamente, este trabalho constitui e define-se como um espaço aberto de mulheres autoras de banda desenhada que procura crescer com futuras propostas para combater o patriarcado heteronormativo.
Formação Continuada de Professores para uma Educação Básica Decolonial: Da Crítica à Autoformação Coletiva
Authors: Nilton Nilton Bruno Tomelin , Buzzi Rausch Rita
Published: December 2023

Este estudo integra uma pesquisa realizada junto a um grupo de professores da Educação Básica de uma Rede Municipal de Ensino de Santa Catarina (Brasil), que se reúne de forma periódica e voluntária para a prática de autoformação coletiva. Este grupo despertou nossa curiosidade em investigar: quais aspectos da formação continuada de professores da Educação Básica, discutidos teoricamente, mobilizaram um grupo de docentes à autoformação voluntária coletiva para uma possível educação decolonial? O objetivo é identificar aspectos da formação continuada de professores da Educação Básica que, segundo a discussão teórica deste estudo, poderão proporcionar uma educação decolonial. A pesquisa é qualitativa e os dados foram gerados por meio de narrativas e analisados a partir do paradigma indiciário. Para fundamentar a discussão, Nóvoa centraliza o debate em torno da imprescindível mudança da escola e da docência, e Canário, Imbernón, Garcia, Roldão e Walsh fortalecem a discussão para uma formação outra. Os principais aspectos da formação continuada de professores que podem proporcionar uma educação decolonial envolvem discussões acerca: a) da compreensão da formação como um treinamento; b) da falta de autoria dos professores em sua formação; c) da falta de conexão entre o que é abordado na formação e o que se vive na prática; d) do fato de que as especificidades e contextos são desconsiderados no cenário formativo docente. Assim, a autoformação coletiva pode ser um caminho para a consolidação da identidade docente, a fim de que seja possível estabelecer uma formação autônoma e colaborativa.
More than Truth: The Hope of Preaching and Its Languages in Context
Authors: Thompson Lisa L.
Published: December 2023

This essay is adapted from a keynote address offered at Societas Homiletica in Budapest, Hungary (August 2022). It frames preaching in shifting social contexts as a practice of theologically ethical meaning-making—supported by accountability to lived experiences, practical wisdom and decision making, and imaginations grounded in boldness and humility. The essay argues that pedagogical strategies in support of these practices prioritize the possibilities that emerge in the constraints of learning contexts. Teaching within the mass crisis of a global pandemic is offered as a case study in the connected outcomes afforded in reassessing one’s presuppositions in both pedagogy and preaching.