bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECT OF ANTIHELMINTHIC THERAPY ON THE SKIN PROCESS IN ROSACEA PATIENTS IN COMBINATION WITH OPISTHORCHIASIS
Authors: Aripova M. L.
Published: June 2020

The article presents results of examination of 144 patients, including 64 patients with rosacea in combination  with  chronic  opisthorchiasis  (group  1)  and  80  patients  with  rosacea  without  opistorchiasis (group 2). Rosacea patients with concomitant chronic opisthorchosis revealed more severe clinical variants. Mean values of the index scale diagnostic assessment of rosacea is significantly higher than in patients rosacea without helminthiasis, indicating a more severe course. Dissatisfaction with the quality of life in patients with rosacea in combination with chronic opisthorchiasis was significantly higher than in patients with rosaceaonly. Patients with rosacea in combination with chronic opisthorchiasis reveled prevalence of anxiety and depression in scale of HADS. There are also were a comparative analysis of the clinical picture in patients with rosacea anthelmintic therapy and without deworming.
DIAGNOSTIC CAPABILITIES OF DIGITAL FLUOROGRAPHY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Gorbunov N. A. , Dergilev A. P. , Sidorova L. D. , Kochura V. I.
Published: June 2020

The purpose of the study – to examine the capabilities of the method of digital chest fluorography in diagnosis of chronic obstructive pulmonary disease (COPD) of different stages. By chest digital fluorography 247 patients with clinically diagnosed COPD stage I–III were examined. The average age of the patients was (55.3  1.7) years (16 to 88 years), forced expiration volume for the first second (FEV1) was (59.17  16.28) %. It was shown that for patients with COPD stage I most characteristic radiographic symptom was emphysema of the lung in the upper regions (26 (48%) of 54 patients); the mean values of the inspiratory lung optical density (ILOD) ranged from (703.48  2.15) to (807.47  5.61) optical density units (ODU), the expiratory lung optical density (ELOD) – from (786.05  6.15) to (830.23  4.71) ODU. For patients with COPD stage II the most common radiographic sign was the presence of amplification and deformation pulmonary pattern (95 (89%) of 107 patients); the mean values of ILOD ranged from (646.20  4.94) to (791.38  2.81) ODU, ELOD – from (677.34  9.91) to (813.91  3.29) ODU. Patients with COPD stage III were characterized by a combination of amplification and deformation pulmonary pattern (77 (90%) of 86 patients) with lung emphysema (51 (59%) of 86 patients); the mean values of the inspiratory lung optical density ranged from (765.93  16.4) to (863.37  15.83) ODU, expiratory lung optical density – from (826.80  11.64) to (881.37  4.29) ODU. Thus, we concluded that the method of digital chest fluorography, possessing low dose burden to the patient, can detect the characteristic radiological symptoms and determine the stage of the disease up to the values of the lung optical density in patients with COPD.
PRIMARY PREVENTION OF POSTOPERATIVE REFLUX DISEASE
Authors: Martynov V. L. , Orlinskaya N. Yu. , Kolchin D. G. , Kurilov V. A. , Kazantsev I. B.
Published: June 2020

Creation of anastomoses between hollow organs of the abdominal cavity, retroperitoneal space and the small intestine always raises the question of the prevention of reflux from the small intestine into the cavity drained the esophagus, stomach, gallbladder, liver outer duct cysts of the liver and pancreas. After surgery, any reflux becomes pathological. Reflux – is an obligate precancer. So, throw the bile and pancreatic juices in the stomach, the stump of the stomach, esophagus contributes to reflux esophagitis, reflux gastritis, ulcers and gastric cancer, or a stump. After an internal drainage of cavity formation in the small intestine develops postoperative reflux disease, which is caused by the actions of the surgeon who tried sincerely to help the patient. It is possible to give the definition of such states “Iatrogenic Postoperative Reflux Disease”.The aim of this work was to develop and put into practice a “cap” on the afferent loop of the small intestine, do not migrate into the gut lumen, with an internal cavity drainage structures of the abdominal cavity and retroperitoneal space and to evaluate clinical outcomes. As a result, the authors have developed a way to create a “cap” on a loop of the small intestine, which is used for the drainage of cavity formation, conducted research on its safety, proper functioning, accessibility, analyzed the clinical situation offers. For drainage of cavernous fistula formation impose between him and a loop of small intestine 40–50 cm from the Treitz ligament. Form a intestine anastomosis by Brown.Above this junction length leads to the formation of the drained portion of the small intestine is about 10 cm, in the middle of which impose a “stub”. Length of discharge from the drainage area of education of the small intestine to interintestinal Brownian anastomosis is about 30 cm. To form a “plug” free land use of the greater omentum, through which by puncture-poke perform ligature of non-absorbable polypropylene material. The developed method for forming a “plug” does not cause drastic changes in the ischemic zone of operation, followed by necrosis of the bowel wall and migration "stub" into the lumen, and its efficiency is demonstrated by clinical observation of microcirculation studies, the results of the water sample, and radiological studies. Way to create a “stub” is promising for internal drainage of abdominal structures of the abdominal cavity and retroperitoneal space, to form a nutrient anti reflux eyunostomy.
EFFECT OF EXOGENOUS AND ENDOGENOUS FACTORS ON THE RATE OF CONSOLIDATION OF FRACTURES OF THE LONG BONES IN OSTEOSYNTHESIS
Authors: Popov V. P.
Published: June 2020

Purpose. Determine endogenous and exogenous factors influencing the pace of consolidation in osteosynthesis implants with different types of coatings. Based on the characteristics of the selected offer the best conditions for the application of bioactive structures.Material and methods. The work is based on an analysis of surgical treatment of 1265 patients with hip fractures, tibial and shoulder. Take into account the influence of age, gender, thе timing of the operation, quality reposition, comorbidities, location and severity of the fracture, implant сoating violation bone repair.Results. Received consolidation using bioactive plates in 99.3 % of patients. Well executed reposition 4.5 times reduced cases of delayed consolidation. The main reason for delayed fracture healing in patients older than 60 years is osteoporosis. Males under 40 years compared with women of the same age often observed slow formation of callus, which is associated with frequent presence in them of comminuted fractures. The most frequently observed sustained fusion in patients with tibial fractures, which is primarily due to the prevalence of lesions in this segment. The main mechanism of action of bioactive positive plates can be explained by the peculiarities microarchitectonics coverage closer to the physiological structure of bone, increasing the concentration of osteogenic cells around the implant and stimulation of their function. Application of bioactive plates most appropriate for osteoporosis, type C lesions, pseudoarthrosis, reoperations during migration and metal fracture, in multiple and combined injuries.
SMALL INTESTINE BACTERIAL OVERGROWTH IN PATIENTS WITH FAILURE OF THE VALVE BAUHINIAS AND AFTER ITS SURGICAL TREATMENTS (THE FIRST RESULTS)
Authors: Martvnov V. L. , Khairdinov A. K.
Published: June 2020

Оbjective: diagnosis of the a small intestine of bacterial overgrowth syndrome (SIBO) in patients with the failure of the bauginias valve (FBV) and after its surgical correction.Material and methods. Patients of the studied groups were examined by means of direct and indirect methods of diagnostics of SIBO. Bacteriological research of an aspirate of aillium gut and other operational material was conducted. To all patients the hydrogen respiratory test was carried out and highquality reaction of urine to an indican was carried out. 50 patients are examined, from them 30 are inclu ded in the main group by which surgical correction of FBV – a bauginoplastik is made; 20 patients are included in group of control at which the illeocecal valve is well-founded. Patients of the main group were examined before operation and for the 7th and 45th days after a bauginoplastik.Results. At all patients of the main group SIBO of varying severity is defined, at 80% of patients of SIBO was localized in distal part of the small intestine. Patients with normal function of the ileocecal valve a SIBO did not suffer. At 76% of patients revealed signs of a mezadenitisof a small intestine, the fact of a bacterial translocation at SIBO is confirmed. In 7 days after surgical correction of the bauginiasvalve normalization of a peak and background excretion of hydrogen was noted at 37% of patients. For the 45th days at all patients the hydrogen digram met standard.Conclusions. The failure of the bauginiasvalveis obligatory followed by a small intestine of bacterial overgrowth syndrome, surgical correction is an effective method of correction of a SIBO at patients with FBV.
COMPARATIVE ANALISYS OF HEMOSTASIS METHODS IN OPERATIONS ON SPLEEN
Authors: Semichev Ye. V. , Baikov A. N. , Bushlanov P. S. , Dambayev G. Ts.
Published: June 2020

The paper provides statistics of spleen traumas, anatomy and characters of the organ damage. The most common methods of spleen hemostasis, currently used in surgical clinics of the Russian Federation, are presented. A small historical excursus about existed methods of hemostasis is given in the paper. A comparative analysis of currently used methods, their advantages and disadvantages is carried out. Some possible criteria for an ideal method of spleen hemostasis are listed as well.
DEMOGRAPHIC CHARACTERISTICS OF THE REPUBLIC OF BURYATIA
Authors: Pisareva L. F. , Lyakhova N. P. , Odintsova I. N. , Perinov D. A. , Chemitdorzhieva Т. N. , Shukhoeva Ye. A.
Published: June 2020

From 1989 to 2013, demographic processes in the Republic of Buryatia were analyzed. Changes in the basic parameters of the population movement: births, deaths and migration were influenced by the sex and age structure of the population. The proportion of the Russians decreased from 69.9% in 1989 to 64.9% in 2010 and the number of the Buryats increased from 24.0 to 29.5%. With the increase in the proportion of residents over 60 years, a process of the aging of the population was observed. In 2000–2013, there was a positive dynamics of the natural movement of the population, the natural increase in /Т ёь9013 was 5,8 per 1000 persons. Migration population decline in the Republic of Buryatia keeps stable.
ANALYSIS OF MEDICAL SERVICE CONTROL PROCESS IN THE SCOPE OF COMPULSORY HEALTH INSURANCE PROGRAM
Authors: Taranik M. A. , Kopanitsa G. D.
Published: June 2020

The relevance of the presented paper deals with the necessity of determining problems and effective solutions for medical organizations on the stage of medical documentation reports control purposely for forecasting the average of financial resources that can be obtained in the scope of compulsory health insurance program.The aim of the study – for the purpose of further issues definition present formal model of the analyzed process using a set of system analysis methods.Material and methods. System analysis methods, especially IDEF0 diagrams and activity diagrams, for estimation of medical expert’s agreement Cohen’s kappa was used.The results. Based on the specification documents and expert’s experience the spread description on the process the control of volume, duration, quality and conditions of medical service assignment by medical organizations conducted by medical insurance organization was presented. Inputs, outputs, elements of management and executives were determined. As a result of decomposition, subprocesess were presented within activity diagrams.Conclusions. The obtained results of research allows to conclude that there is a set of problems which appear when medical organizations send reports for getting financial resources for clinical service realization in the scope of compulsory health insurance program. On the grounds of determined problems, we can conclude that it is necessary to develop an intellectual information system for estimating clinical records concerning getting financial resources for clinical service. In respect that human factor influence on the main stages of the analyzed process, we propose to use fuzzy logic as an inference engine. The self-learning function of the system will provide case-based reasoning.
TO THE HISTORY OF THE DEPARTMENT OF PROPEDEUTICS OF INTERNAL DISEASES OF SIBERIAN STATE MEDICAL UNIVERSITY. SCIENTIFIC TRENDS, PROBLEMS AND ACHIEVEMENTS
Authors: Tetenev F. F.
Published: June 2020

The history of the oldest Department of theSiberianStateMedicalUniversity– Department of Propedeutics of Internal Diseases has been presented
MORPHOLOGICAL CHARACTERISTICS OF POSTTRAUMATIC SKELETAL MUSCLE REGENERATION AFTER EXPERIMENTAL BLAST INJURY
Authors: Vengerovich N. G. , Shperling I. A. , Yurkevich Yu. V. , Vladimirova O. O. , Alekseyeva I. I. , Shulepov A. V. , Shchipanov S. G. , Shperling N. V. , Romanova Ye. V.
Published: June 2020

The research objective was a morphological analysis of posttraumatic regeneration of musculoskeletal tissue in rats after experimental blast injury with field simulation of remote musculocutaneous injury of lower limbs. Wound process was evaluated visually and by histological characteristics of injury zones. This research helped to deepen understanding of details of regenerative process of blast musculocutaneous injury and formation of regenerating muscular and connective tissue of skeletal muscle in rats
ROLE FAILURE CORRECTION OF 25(OH)D IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME
Authors: Matveyeva M. V. , Samoylova Yu. G. , Oleynik O. A. , Koshmeleva M. V. , Rotkank M. A.
Published: June 2020

Objective. To estimate the correction failure 25 (OH) D in patients with polycystic ovary syndrome.Material and Methods. The study involved 44 patients with polycystic ovary syndrome, aged 31.32 ± 5.05, who were randomly assigned to 2 groups: 1st – obtained coca biguanides and Kolekaltsiferol, second – combined oral contraceptive (combined hormonal ) and biguanides. The comparison group consisted of 22 healthy women matched for age and sex. Polycystic Ovarian Syndrome (PCOS) was verified on theОригинальные статьиБюллетень сибирской медицины, 2015, том 14, № 5, с. 47–53 53basis of diagnostic criteria ESHRE / ASRM (2012). 25 (OH) vitamin D was determined by enzyme-linked immunosorbent assay (ELISA ng/ml). Examined glucose and fasting insulin, HOMA index of insulin re-sistance. Depression was assessed using the Beck test. Statistical analysis – R-system.Results. The patients with PCOS defined by the expression deficit of 25 (OH) D, which is associated with hyperandrogenism, hyperglycemia, hyperinsulinemia, insulin resistance, as well as depression. Ad-mission kolekaltsiferola leads to improved glucose metabolism and manifestations of PCOS, and also significantly reduces the parameters of OT, OT / OB, depression.Conclusion. Failure correction of 25 (OH) D contributes to the improvement of metabolic and psycho-logical parameters of fertility.
COMPARATIVE MORPHOFUNCTIONAL CHARACTERISTIC OF ADRENAL GLANDS IN ARTERIAL HYPERTENSION
Authors: Alyabyeva S. Yu. , Paderov Yu. M. , Alyabyev F. V. , Tetenev F. F.
Published: June 2020

The article is devoted to the study of morphological changes of the adrenal glands in arterial hyperten-sion. Adrenals investigated persons who do not suffer in life and suffering from hypertension during the life of hypertension and died from various causes – is incompatible with the life of a mechanical trauma, cerebral hemorrhage, and acute left ventricular failure. In each case, each of the adrenal glands were assessed: the presence and severity of focal and diffuse mononuclear infiltration, the number of lympho-cytes, monocytes, plasma cells and fibroblasts arranged in the respective zones of the cortex and medulla, the severity of hyperemia and edema of various structural parts, the number of zones cortex and medulla endocrinocytes with pycnotic nuclei in the reticular zone evaluated the distribution of secretory cells with lipofuscin and the degree of saturation of the cytoplasm of the secretory cells, in secretory cells of medul-la evaluated nuclear-cytoplasmic ratio, the severity of vacuolization and basophils cytoplasm revealed a number of regularities of morphological changes depending from the various clinical manifestations of hypertension, defining the ultimate option of dying. At the heart tanatogenesis version are more pro-nounced morphological features hyperfunctions glomerular zone – namely delipidization left and right glands. The beam and netted areas contralateral glands embodiment of dying of a heart compared to the brain, is more pronounced hyperemia. When cardiac variant tanatogenesis more pronounced focal lym-phoid infiltration and vacuolization in secretory cells of left adrenal medulla.
STRUCTURE OF THE NODULAR GOITER IN CHILDREN
Authors: Rogova O. S. , Samsonovа L. N. , Okminyan G. F.
Published: June 2020

For today the question of early diagnosis of nosological variants, the method of treatment and prevention of nodular goiter in children is still not fully resolved. There is a few available literature data about study of this problem in children. Objective: to study morphofunctional structure of thyroid nodules in children.

The article provides information consisting of the results of a retrospective analysis of case histories of 73 patients, operated with nodular goiter in Z.A. Bashlyaeva Children’sCityClinicalHospital(Moscow) from 2003 to May 2015. The examination included an evaluation of the functional status of the pituitary-thyroid system: there were investigated serum thyroxine, triiodothyronine and thyroid stimulating hor-mone, also was performed thyroid scintigraphy 99mТc. In the postoperative period, there was carried out a final verification of the diagnosis according to the results of the histological conclusion. The histologi-cal type of nodal disease was defined by the WHO classification of 2004. It was established that in the structure of a single-node goiter in children prevail nodular colloid goiter with equal frequency in boys and girls, with the same frequency occurs thyroid adenoma, but more often in girls than in boys. The multinodular goiter equally often detected in girls and boys both nodular goiter colloidal with varying degree of proliferation and colloid in combination with follicular thyroid adenoma. "Hot" nodes in the multinodular goiter are more common than in the single-node goiter and more fre-quently in girls than in boys. The half of children with nodular pathology have "hot" nodes and one out of every three – decompensated form of functional autonomy. Decompensated form of functional autonomy of the thyroid gland in children with "hot" nodes detects regardless of the number of nodes. Papillary thyroid cancer occurs not only in patients with a single-node, but with a multinodular goiter. The results allow to draw conclusions about the heterogeneity of the morphological structure as a single-node and multinodular goiter in children, including papillary thyroid cancer.
NEW CANDIDATE GENES FOR SUSCEPTIBILITY TO TUBERCULOSIS IDENTIFIED THROUGH THE CONSTRUCTION AND ANALYSIS OF ASSOCIATIVE NETWORKS
Authors: Bragina Ye. Yu. , Rudko A. A. , Tiys Ye. S. , Ivanisenko V. A. , Freidin M. B.
Published: June 2020

Tuberculosis (TB) is a common disease caused by infection of Mycobacterium tuberculosis and influenced by host hereditary and environmental factors. Accumulated genomic data obtained through the use of new methodological approaches, including analysis of associative networks, contribute to the understanding of the hereditary basis of the disease. In the current study, we carried out the reconstruction and analysis of associative network representing molecular genetic links between proteins/genes involved in the development of TB. In the associative network, well studied proteins and genes with a decisive importance in the efficiency of the human immune response against a pathogen predominated. However, this approach identified 12 new genes encoding for the respective proteins in the associative network polymorphismsof which has not been studied regarding the development of TB.
THE SOCIAL AND CLINICAL CHARACTERISTIC OF PATIENTS WITH THE ISOLATED GENITAL TUBERCULOSIS ASSOCIATED WITH INFERTILITY, THE ACTIVE AND CLINICALLY CURED TUBERCULOSIS OF RESPIRATORY ORGANS IN COMBINATION WITH PREGNANCY
Authors: Mordyk A. V. , Valeyeva G. A. , Yakovleva A. A. , Puzyreva L. V.
Published: June 2020

Due to the high incidence of tuberculosis of women of reproductive age research at 270 patients was conducted. The group of research included women with infertility and genital tuberculosis, pregnant women with active tuberculosis of lungs, pregnant women with clinically cured tuberculosis of respiratory organs. Pregnant women with tuberculosis of lungs were more often from sociopathic families, had venereal diseases, HIV infection, hepatitises.
POSTPARTUM DEPRESSION – THE CENTRAL PROBLEM OF MENTAL HEALTH OF EARLY MOTHERHOOD
Authors: Kornetov N. A.
Published: June 2020

Perinatal mental health of the mother occupies a central position in healthcare, the same as caring for a newborn baby. Maternal depression is the lead pathology of postpartum period. Despite the high prevalence and importance to the overall development of children, most cases of depression are unappreciated, unrecognized and untreated. Inattention to issues which are related to physical and mental health of women, leads to severe negative social and economic consequences for society. Statistical comparison of the total number of pregnant women, the number of births in the United States in 2007, excluding cases of fetal loss, including still-births and miscarriages with similar Russian data allowed to calculate the approximate prevalence of postpartum depression in the same period. Presumable probability of postpartum depression is 15% in different regions of the world, and the diagnostic criteria of DSM-IV for postpartum depression are representative for comparison. Considering these assumptions, according to 2007 each year about 260,000 out of 1 mln. 600,000 of Russian women in childbirth may suffer from post-natal depression. The results have a probabilistic character. For the mothers the consequences of unrecognized and untreated depression after childbirth are the most frequent. It should be seen as a depressive episode or recurrent depressive disorder which has a singular coloring due to the appearance in the peak period of reproductive age of women. Postpartum depression may increase the possibility of occurrence of relapse of a depressive disorder as well as the transition to a state of chronic depression. Alcoholism or drug use is a common complication of depression; the risk of suicide increases, especially during the time of reducing the severity of the most severe symptoms of depression, though it is below the prevalence of suicide among the population. Particular attention should be paid to such symptoms as instability in mood and irritability as during the postpartum depression and in its residual period. They can cause child abuse. This paper also presents current data on the epidemiology, etiology, risk factors for postpartum depression, its clinical manifestations, the influence of untreated maternal depression on child development, therapy and educational modules to spread multidisciplinary and inter-agency approach in perinatal mental health problems.
THE ROLE OF PROTEIN OXIDATIVE MODIFICATION IN REDOX-REGULATION OF CASPASE-3 ACTIVITY IN BLOOD LYMPHOCYTES DURING OXIDATIVE STRESS IN VITRO
Authors: Nosareva O. L. , Stepovaya Ye. A. , Ryazantseva N. V. , Shakhristova Ye. V. , Vesnina O. N. , Novitsky V. V.
Published: June 2020

The formation of oxidative stress lies at the heart of many frequent and socially-important diseases. Blood lymphocytes are the cells which provide immunological control of our organism. As a result of their function implementation blood lymphocytes contact with different endogenic and exogenic factors, which can lead to active oxygen species production activation, macromolecules oxidative modification and to cell survival alteration. At the present time it is essential to expand and deepen the fundamental knowledge of blood lymphocytes apoptosis regulation peculiarities. The research objective was to establish the interaction among alterations of glutathione system condition, carbonylation level, protein glutathionylation and caspase-3 activity in blood lymphocytes during oxidative stress in vitro.

Material and Methods. The material for research was blood lymphocytes cultivated with addition of hydrogen peroxide in final concentration of 0,5 mmol and/or protein SH-group inhibitor N-ethylmaleimide – 5 mmol, protector – 5 mmol – 1,4-dithioerythritol. Reduced, oxidized and protein-bound glutathione concentration was measured by method of spectropho-tometry, additionally, the ratio size of reduced to oxidized thiol fraction was estimated. With help of enzymoimmunoassay the level of protein carbonyl derivatives was evaluated; caspase-3 activity was registered by spectrofluorometric method.

Results. Protein SH-group blocking in blood lymphocytes during oxidative stress in vitro was accompanied by protein-bound glutathione concentration rapid decrease in connection with increase of protein carbonyl derivatives content and caspase-3 activity. Protein SH-group protection in blood lymphocytes during oxidative stress in vitro was accompanied by concentration increase of protein-bound glutathione and protein carbonyl derivatives under comparable values of enzyme activity under study.

Conclusion. The carried out research shows that caspase-3 and protein-bound glutathione are the molecular targets of selective control over programmed cell death. The received indices of caspase-3 activity change and protein-bound glutathione concentration alteration in blood lymphocytes during oxidative stress in vitro can be used when elaborating target therapy approaches to diseases accompanied by apoptosis disregulation.
PHARMACOEPIDEMIOLOGICAL AND PHARMACOECONOMIC ANALYSIS OF TREATMENT OF ENDOMETRIT IN-HOSPITAL
Authors: Chernikova L. Yu. , Belousov M. V.
Published: June 2020

Pharmacoepidemiological and pharmacoeconomical analysis of endometrit drug therapy at special treatment-and-prophylactic institutions of the city of Tomsk. Estimate the intensity of the appointment of antibacterial drugs endometrit therapy using the methodology of the WHO ATC/DDD, calculated indicators of the intensity of the consumption of drugs in the course of treatment per patient. It was shown that 70% of the established daily dose had to beta-lactam antibiotics and macrolide. For the most common options for antibiotic therapy established nosology of the indicators of clinical efficacy. The calculation of the cost of the schemes of antibiotic therapy, which showed that the cost of treatment is maximal during therapy with ceftriaxone + clarithromycin (4902 RUR); further descending follow: amoxicillin / clavulanic acid + roxithromycin (4658 RUR); benzylpenicillin and gentamicin (4231 RUR). Economic efficiency of antibacterial treatments endometritis a “cost – effectiveness”. The cost of the patient, achieved remission, made during therapy with amoxicillin/clavulanic acid and roxithromycin (5416 RUR), During therapy with ceftriaxone and clarithromycin (6052 RUR), the treatment of benzylpenicillin and gentamicin (14420 RUR). Pharmacoeconomic evaluation results showed that the least acceptable scheme of antibacterial therapy of endometrit in the hospital is the combination of benzyl penicillin and gentamicin. Тhe antibiotic therapy for endometrit may be recommended by a combination of amoxicillin / clavulanic acid and roxithromycin and clarithromycin and ceftriaxone, for which there was no statistically significant differences in clinical efficacy and cost of antibiotic therapy.
Histochemical research of cells functionally leading tissue liver and kidneys of rats after intravenous application of nanoparticles magnetite
Authors: Milto I. V. , Sukhodolo I. V. , Klimentiyeva T. K. , Shevtsova N. M.
Published: June 2020

After unitary and repeated intravenous application magnetite is shown their distribution in organism of a rat by method of magnetic resonance imaging. Accumulation of particles in a liver and a spleen of animals is shown. We studied intracellular activity main enzymes of hepatocyte and nephrocyte rats in various periods after intravenous application of nanoparticles magnetite by histochemical method. Intravenous application of magnetite is accompanied change of energetic and plastic metabolism of studied cells.
Evaluation of Clause-Column Table method to design of MIC hazard-free in asynchronous finite state machines
Authors: Almeida Tiago da Silva , Luiz Gomes de Freitas André
Published: June 2020

Asynchronous finite state machines are of great interest because they use fewer transistors to manufacture them. However, find the minimum resources in logic modeling is an NP-Problem, since the search space increase exponentially. Although this problem is studied for some time, there is still space for newer researches. Mostly, in new computational methods to improve performance in solving logical optimization in finite state machines. Thus, this paper presents a study and evaluation of heuristic algorithms for the optimization of asynchronous finite state machines, to obtain the smallest possible circuit. Thus, the Clause-Column Table and Quine-McCluskey algorithms are combined in order to propose an algorithm capable of minimizing asynchronous sequential circuits. Tests and results show that it is possible to synthesize circuits in a reasonable time, but with some logical errors. It may be concluded that it still needs research, even though it is not such a recent line of research.
Multilayer Perceptron optimization through Simulated Annealing and Fast Simulated Annealing
Authors: Henrique Cardoso Camelo Pedro , De Carvalho Rafael Lima
Published: June 2020

The Multilayer Perceptron (MLP) is a classic and widely used neural network model in machine learning applications. As the majority of classifiers, MLPs need well-defined parameters to produce optimized results. Generally, machine learning engineers use grid search to optimize the hyper-parameters of the models, which requires to re-train the models. In this work, we show a computational experiment using metaheuristics Simulated Annealing and Fast Simulated Annealing for optimization of MLPs in order to optimize the hyper-parameters. In the reported experiment, the model is used to optimize two parameters: the configuration of the neural network layers and its neuron weights. The experiment compares the best MLPs produced by the SA and FastSA using the accuracy and classifier complexity as comparison measures. The MLPs are optimized in order to produce a classifier for the MNIST database. The experiment showed that FastSA has produced a better MLP, using less computational time and less fitness evaluations.
Synergistic Hepatoprotective Interaction between α-Tocopherol and Ascorbic Acid on Paracetamol Induced Liver Damage in Rats
Authors: Khan Saidul Islam , Begum Mahmuda , Chowdhury Rama , Rahman Md. Mizanur , Asaduzzaman Muhammad
Published: June 2020

Background and objectives: The hepatoprotective activity of vitamin E and C is evident due to their ability of modulating the antioxidant pathway. In this study, we have evaluated the effects of α-tocopherol and ascorbic acid on paracetamol induced liver damage with offsetting various levels of drug treatment following an in vivo experimental protocol on Wistar albino male rats. Materials and Methods: The level of lipid peroxidation as well as histological examination of liver tissues were observed among 50 Wistar albino male rats to evaluate hepatoprotective effect of α-tocopherol and ascorbic acid on hepatocytes. The experiment was divided into 5 groups (10 rats in each group)- Basal control group (Group-I, with propylene glycol), Paracetamol treated control group (Group –II), α-tocopherol pretreated & paracetamol treated group (Group –III), Ascorbic acid pretreated & paracetamol treated group (Group –IV) and Ascorbic acid pretreated & paracetamol treated group (Group –IV). Results: The mean (± SD) Malondialdehyde (MDA) concentration were significantly reduced in α-tocopherol pretreated and paracetamol treated group (P<0.001), Ascorbic acid pretreated and paracetamol treated group (P≤0.05) and combined α-tocopherol with ascorbic acid pretreated & paracetamol treated group (P<0.001). Statistically significant differences in histological findings of rat liver were observed in paracetamol treated control group (P<0.001), ascorbic acid pretreated and paracetamol treated group (P<0.001). The serum alanine aminotransferase (ALT) level was also significantly higher in paracetamol treated group (P<0.001), α-tocopherol pretreated plus paracetamol treated group (P≤0.05) and in ascorbic acid pretreated plus paracetamol treated group (P<0.001). Conclusion: The combined pretreatment of α-tocopherol & ascorbic acid have better hepatoprotective effects than α-tocopherol or ascorbic acid alone against paracetamol induced liver damage. The decrement of free radicals produced by vitamin E could be a better hepatoprotective antioxidant than vitamin C in paracetamol induced toxicity.
Predictive Value of CCNB1, BUB1B and TTK in the Progression and Prognosis of Lung Adenocarcinoma
Authors: Xiong Lecai , Bai Yuquan , Zhu Minglin , Yang Zetian , Zhao Jinping , Tang Hexiao
Published: June 2020

Lung cancer predominates in cancer-related deaths worldwide, with lung adenocarcinoma (LUAD) being a common histological subtype of lung cancer. The aim at this study was to search for biomarkers associated with the progression and prognosis of LUAD. We have integrated the expression profiles of 1174 lung cancer patients from five GEO datasets (GSE18842, GSE19804, GSE30219, GSE40791 and GSE68465) and identified a set of differentially expressed genes. Functional enrichment analysis showed that these genes are closely related to the progression of LUAD, such as cell cycle, mitosis and adhesion. Cytoscape software was used to establish a protein-protein interaction (PPI) network to analyze important modules using Molecular Complex Detection (MCODE), and finally CCNB1, BUB1B and TTK were selected for further study. The study found that compared with non-tumor lung tissue, CCNB1, BUB1B and TTK are highly expressed in LUAD. Kaplan-Meier analysis showed that CCNB1, BUB1B and TTK were negatively correlated with the overall survival and disease-free survival of patients. Gene set enrichment analysis (GSEA) demonstrated that for the samples of any hub gene highly expressed, most of the functional gene sets enriched in cell cycle. In summary, CCNB1, BUB1B and TTK can be used as biomarkers of poor prognosis of LUAD. The high expression of CCNB1, BUB1B and TTK can accelerate the progression of LUAD and lead to shorter survival, suggesting that they may be potential targets for treatment in LUAD.
Comparison of a Triple Inverted Pendulum Stabilization Using Optimal Control Technique
Authors: Jibril Mustefa , Tadese Messay , Tadese Eliyas Alemayehu
Published: June 2020

In this paper, modelling design and analysis of a triple inverted pendulum have been done using Matlab/Script toolbox. Since a triple inverted pendulum is highly nonlinear, strongly unstable without using feedback control system. In this paper an optimal control method means a linear quadratic regulator and pole placement controllers are used to stabilize the triple inverted pendulum upside. The impulse response simulation of the open loop system shows us that the pendulum is unstable. The comparison of the closed loop impulse response simulation of the pendulum with LQR and pole placement controllers results that both controllers have stabilized the system but the pendulum with LQR controllers have a high overshoot with long settling time than the pendulum with pole placement controller. Finally the comparison results prove that the pendulum with pole placement controller improve the stability of the system.
THE EVALUATION STUDIES OF KAMPUNG KB IN CENTRAL JAVA
Authors: Handayani Arri , Najib  , Ardini Sukma Nur , Yulianti Padmi Dhyah
Published: June 2020

Kampung KB becomes one of the strategic innovations to implement the priority activities of the KKBPK Program as an effort to achieve the target of the Development of Population and Family Planning Control (Pembangunan Bidang Pengendalian Penduduk dan Keluarga Berencana). The data collected through a qualitative approach. The instrument used was an interview guide to conduct an in-depth interview with various participants. The location of the study was chosen by purposive technique; Magelang, Sukoharjo, and Temanggung. The data are grouping into input, process, and output. Related to the input, the establishment of Kampung KB is already by the guidelines, people's participation is quite good, but the support of facilities and infrastructure is still at a minimum level. About the process, the consuming data came from 2015, coaching and movement are not regularly scheduled. The last relates to the output, that is Kampung KB activities such as Tri Bina (BKB, BKR, BKL), UPPKS, PIK-R, learning guidance, and libraries, while activities from across sectors include drainage, privies, corn seedling, home industry training, duck livestock training, and infrastructure improvements. However, the improvement of the KKBPK program achievements has not been completed, even though it changes the social welfare.

Keywords: input, kampung KB, output, process

 

Studi Evaluasi Kampung KB di Jawa Tengah

Abstrak

Kampung KB menjadi salah satu inovasi strategis untuk dapat mengimplementasikan kegiatan-kegiatan prioritas Program KKBPK sebagai upaya pencapaian target Pembangunan Bidang Pengendalian Penduduk dan Keluarga Berencana. Pengumpulan data melalui pendekatan kualitatif. Instrumen yang digunakan pedoman wawancara untuk melakukan wawancara mendalam dengan berbagai informan. Lokasi penelitian dipilih secara purposif yaitu kota magelang, kabupaten sukoharjo, dan kabupaten temanggung. Berdasarkan hasil penelitian data pendekatan kualitatif, terdapat tiga kelompok yang meliputi input, proses, output. Pertama, berkaitan dengan input yakni pembentukan wilayah kampung KB sudah sesuai pedoman, partisipasi masyarakat cukup baik, namun dukungan sarana dan prasarana masih sangat minim. Kedua, berkaitan dengan proses yakni data, pembinaan dan penggerakan belum terjadwal secara rutin. Ketiga, berkaitan dengan output yakni bentuk kegiatan dikampung KB diantaranya Tri Bina (BKB, BKR, BKL), UPPKS, PIK-R, bimbingan belajar dan perpustakaan pintar, sedangkan kegiatan dari lintas sektor diantaranya meliputi drainase, jambanisasi, pembibitan jagung, bank sampah, pelatihan home industry, pelatihan ternak bebek, dan perbaikan infrastruktur. Namun, peningkatan capaian program KKBPK belum sepenuhnya terpenuhi, walaupun membawa sedikit perubahan pada kesejahteraan masyarakat.

Kata kunci: input, kampung KB, output, proses
Medial Condyle Fractures of the Humerus in the Pediatric Population: Diagnostic Challenges
Authors: Zukotynski Brian K. , Alswang Jared M. , Silva Mauricio
Published: June 2020

Case:

We describe 3 cases of children, ages ranging from 3 years 11 months to 6 years 3 months, who presented with medial condyle fractures (MCF) over a 3-year period with 3 distinct treatment outcomes.

Conclusion:

Pediatric MCFs are rare and difficult to diagnose, but evidence of severe edema in the presence of an apparent avulsion fracture on the medial side of the elbow in patients younger than 6 years old could suggest the possibility of a displaced fracture of the medial humeral condyle and additional assessment involving evaluation under anesthesia, arthrography, or advanced imaging may be warranted. Open reduction with internal fixation should be considered for displaced fractures.
Simultaneous Posterior Shoulder Dislocation and Acromioclavicular Joint Separation: Single-Stage Arthroscopic Treatment of Combined Injuries
Authors: Toft Felix , Scheibel Markus
Published: June 2020

Case:

We report on a patient who received arthroscopic treatment after a unique traumatic combined injury comprising a posterior shoulder dislocation with posterior labrum damage, a reverse Hill-Sachs lesion, and a concomitant Rockwood type-V acromioclavicular joint dislocation.

Conclusion:

Arthroscopy was applied to address all pathologies in a single-stage procedure. The outcome of reduced operating and patient recovery time suggests that our intervention is ideal for this specific indication.
Early Modern Scotists and Thomists on the Question on the Intellect’s First and Adequate Object (15th-17th Centuries)
Authors: Tropia Anna
Published: June 2020

This paper analyses the criticisms put forward by the Scotists of the 17th century to Thomas Aquinas’ commentators on the subject of the intellect’s first object. What the intellect knows first, and what the extension of human cognition is, are questions that Aquinas addressed in several places in Summa theologiae, presenting conclusions which Scotus famously criticised. From the 15th century on, observed the tendency among Aquinas’ commentators to adjust themselves to Scotus’ opinion concerning this matter. The paper includes a collection of the texts they mention and focuses on this ‘shift’ in the history of Aquinas’ readings.
La enseñanza de la filosofía natural en la última época colonial chilena: el Tratado acerca de los elementos y las Instituciones de física de Manuel Antonio Talavera
Authors: Aravena Zamora Abel Marcelo
Published: June 2020

El artículo revisa los contenidos generales del Tratado Acerca de los elementos (1792) de Manuel Antonio Talavera, que es parte de los capítulos que estudian la Física especial en su obra Instituciones de Física. En ésta, se combinan las doctrinas de filosofía natural según las enseñanzas de los filósofos modernos (Recentiores), los nuevos datos empíricos generados a partir de los experimentos científicos y la autoridad de las Escrituras. Se intenta mostrar cómo en la enseñanza de la disciplina durante la última época colonial convivieron conocimientos propios de la modernidad matizados con elementos característicos de la escolástica. Presentamos una breve nota biográfica del autor y revisamos desde una perspectiva general los principales aspectos del tratado. La intención es visibilizar el quehacer educativo de Talavera y rescatar parte del legado filosófico latinoamericano.
Joëlle Ducos and Christopher Lucken (eds.), Richard de Fournival et les sciences au XIIIe siècle. Micrologus Library 88, Firenze, SISMEL, 2018, vi + 443 pp., ISBN: 97888845 08430. Cloth €68
Authors: DELAURENTI BÉATRICE
Published: June 2020

Reseñado por BÉATRICE DELAURENTI EHESS,

Centre de Recherches Historiques, Paris, FR

beatrice.delaurenti@ehess.fr
Antoni Bordoy Fernández, Enseñar filosofía en los albores de la universidad (1200-1240). Estudio histórico acompañado del acceso de los filósofos a las siete artes liberales, Madrid, Sindéresis, 2018, 348 pp., ISBN: 9788416262533. Cloth €20
Authors: RUIZ ENCARNACIÓN
Published: June 2020

Reseñado por ENCARNACIÓN RUIZ CALLEJÓNUniversidad de Granada, ESruizencarnacion@ugr.es
Amy M. Austin and Mark D. Johnston (eds.), A Companion to Ramon Llull and Lullism. Brill's Companions to the Christian Tradition 82, Leiden and Boston, Brill, 2019. xxvi + 557 pp., ISBN: 9789004226227. Cloth €249
Authors: DOMÍNGUEZ FERNANDO
Published: June 2020

Reseñado por FERNANDO DOMÍNGUEZ REBOIRASAlbert-Ludwigs-Universität Freiburg, DEfernando.dominguez@theol.uni-freiburg.de
Herbert L. Kessler and Richard G. Newhauser with the assistance of Arthur J. Russell, Optics, Ethics, and Art in the Thirteenth and Fourteenth Centuries: Looking into Peter of Limoges's Moral Treatise on the Eye, Studies and Texts 209; Text Image Context:
Authors: Mantas Pedro
Published: June 2020

Reseñado por CHRISTIAN ETHERIDGENational Museum of Denmark, Copenhagen, DKwyvern_hoo2@hotmail.co.uk
Pencatatan dan Pembukuan Via Aplikasi Akuntansi UMKM di Sidoarjo
Authors: Muljanto Muhammad Agus
Published: June 2020

Di Sidoarjo Selatan para pelaku UMKM bergerak diberbagai bidang perekonomian. Permasalahan yang ditemukan adalah minimnya pengetahuan dan pemahaman mereka tentang akuntansi khususnya pencatatan dan pembukuan hingga penyusunan laporan keuangan. Pemahaman mereka sebelumnya bahwa pencatatan dan pembukuan itu sulit, merepotkan, dan menyita waktu menjadi penghambat untuk belajar akuntansi. Untuk itu pencatatan akuntansi berbasis teknologi menjadi penting terutama pada UMKM. Permasalahan yang dihadapi pelaku UMKM adalah belum adanya pelatihan pengelolaan keuangan usaha menggunakan aplikasi secara langsung. Solusi yang dibutuhkan adalah penyuluhan dan pendampingan bagi pelaku UMKM dalam mengelola keuangan menggunakan aplikasi akuntansi UMKM. Tujuannya agar pelaku UMKM mau dan disiplin menggunakan aplikasi akuntansi UMKM yang mudah digunakan secara mobile dengan media gadget dan sebagai upaya peningkatan kesadaran membayar pajak bagi pelaku UMKM. Pelaksanaan pengabdian masyarakat di Kantor Pelayanan Pajak Pratama Sidoarjo Selatan berjalan dengan baik dan dilaksanakan dengan 3 (tiga) metode. Peserta antusias dan bersemangat mengikuti kegiatan sampai selesai meskipun di awal pendampingan beberapa peserta mengalami kesulitan karena gaptek. Harapan kedepan agar pelaku UMKM di Sidoarjo Selatan mau dan disiplin untuk mencatat setiap aktivitas keuangan secara harian atau secara berkala dengan menggunakan aplikasi akuntansi UMKM dan patuh dalam melaporkan dan membayarkan pajaknya.
Pemanfaatan Lahan Kosong Sekolah Sebagai Taman Toga
Authors: Utami Asih
Published: June 2020

Sekolah merupakan tempat menuntut ilmu yang harus diperhatikan kenyamanan dan keindahannya. Kondisi tanah di Kalimantan yang pada umumnya tanah gambut membuat orang malas untuk mengolahnya karena butuh perawatan dan penanganan khusus. Hal ini juga terjadi di lahan sekolah yang bertanah gambut. Seperti yang terjadi di SMPN 5 Katingan Hilir. Sebagian lahan yang tidak didirikan bangunan dibiarkan kosong bahkan tidak jarang menjadi hutan liar jika jarang dibersihkan. Padahal lahan kosong sekolah sangat potensial untuk diperdayakan menjadi tanah yang produktif mengingat banyak sumber daya manusia di lingkungan sekolah seperti siswa dan guru. Dengan kondisi tersebut, penulis melakukan pengabdian dengan memberikan pelatihan kepada guru dan murid di SMPN 5 katingan Hilir dalam mengelola lahan kosong sekolah menjadi taman toga. Hasil capaian pengabdian masyarakat ini adalah terbentuknya taman toga di SMPN 5 Katingan Hilir atas partisipasi aktif siswa,guru dan kepala sekolah. Program taman toga di SMPN 5 Katingan Hilir ini akan terus dikembangkan meskipun kegiatan pengabdian kepada masyarakat yang dilakukan telah selesai.