bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterizing Forest Fuel Properties and Potential Wildfire Dynamics in Xiuwu, Henan, China
Authors: Shi Yan , Feng Changping , Zhang Liwei , Huang Wen , Wang Xin , Yang Shipeng , Chen Weiwei , Xie Wenjie
Published: December 2023

As global climate change and human activities increasingly influence our world, forest fires have become more frequent, inflicting significant damage to ecosystems. This study conducted measurements of combustible materials (moisture content ratio, ignition point, and calorific value) across 14 representative sites. We employed Pearson correlation analysis to ascertain the significant differences in combustible properties and utilized entropy methods to evaluate the fire resistance of materials at these sites. Cluster analysis led to the development of four combustible models. Using BehavePlus software, we simulated their fire behaviors and investigated the effects of wind speed and slope on these behaviors through sensitivity analysis. The results revealed notable differences in the moisture content ratios among different types of combustibles, especially in sites 2, 3, 8, 9, and 13, indicating higher fire risks. It was also found that while humus has a higher ignition point and lower calorific value, making it less prone to ignite, the resultant fires could be highly damaging. The Pearson analysis underscored significant variations in the moisture content ratios among different combustibles, while the differences in ignition points and calorific values were not significant. Sites 5 and 6 demonstrated stronger fire resistance. The simulations indicated that fire-spread speed, fireline intensity, and flame length correlate with, and increase with, wind speed and slope. Sensitivity analysis confirmed the significant influence of these two environmental factors on fire behavior. This study provides critical insights into forest fire behavior, enhancing the capability to predict and manage forest fires. Our findings offer theoretical support for forest fire prediction and a scientific basis for fire management decision-making.
Minor Title Change: Fossils Becomes Fossil Studies
Authors: Buffetaut Eric ,   Fossil Studies Editorial Office
Published: December 2023

The journal Fossils [...]
Genealogical Memory and Its Function in Bridging the ‘Floating Gap’
Authors: Parowicz Izabella
Published: December 2023

The concept of genealogical memory is commonly presumed to be synonymous with family or intergenerational memory. However, this paper asserts the necessity for a more detailed examination, seeking to refine and contextualize these notions from a genealogist’s perspective. Exploring the focal point of this study, genealogical memory unveils distinctive characteristics that warrant meticulous scrutiny. Foremost among these characteristics is its intentional nature and inherently reconstructive essence, enabling the recollection of long-deceased ancestors and contemplation of their fates. Consequently, genealogical memory proves invaluable in bridging the ‘floating gap’ between communicative and cultural memory, as posited by Jan Vansina’s conceptualization. The primary objective of this article is to comprehensively explore and structure the concept of genealogical memory, with a particular focus on the genealogist’s role as a memory-maker.
Spatial and Temporal Patterns of Land Subsidence and Sinkhole Occurrence in the Konya Endorheic Basin, Turkey
Authors: Orhan Osman , Haghshenas Haghighi Mahmud , Demir Vahdettin , Gökkaya Ergin , Gutiérrez Francisco , Al-Halbouni Djamil
Published: December 2023

The endorheic Konya Basin is a vast aggradational plain in Central Anatolia, Türkiye. It occupies a significant portion of Konya Province, covering approximately 50,000 km2. The basin is subjected to intense groundwater withdrawal and extensive agricultural activities with excessive irrigation. These activities have led to human-induced hazards, such as sinkholes and regional land subsidence. Although sinkhole occurrence mainly occurs in the Karapınar area, land subsidence is primarily observed in the central sector of Konya city, with 2 million inhabitants, as well as in various parts of the basin. This study focuses on determining the extent and rate of land subsidence throughout the basin, understanding sinkhole formation, and unraveling their relationship with anthropogenic activities. For this purpose, Interferometric Synthetic Aperture Radar (InSAR) analysis of Sentinel-1 data from 2014 to 2022 was conducted to identify and assess land subsidence. We also used the land cover data and groundwater-level information to better understand the spatial and temporal patterns of land subsidence and sinkhole occurrence. Additionally, the land cover data were used to resolve spatial–temporal variations in the cultivated area and urbanization, which are the main factors governing groundwater exploitation in the region. Our study identified widespread subsidence zones with rates as high as 90 mm/y. Groundwater overexploitation to sustain extensive agricultural operations is the main cause of the high rate of land subsidence. Additionally, it was discovered that the number of sinkholes has substantially increased due to anthropogenic influences, currently amounting to as many as 660.
Care Delivery Interventions for Individuals with Cancer: A Literature Review and Focus on Gastrointestinal Malignancies
Authors: Lam Anh B. , Moore Vanessa , Nipp Ryan D.
Published: December 2023

Background: Gastrointestinal malignancies represent a particularly challenging condition, often requiring a multidisciplinary approach to management in order to meet the unique needs of these individuals and their caregivers. Purpose: In this literature review, we sought to describe care delivery interventions that strive to improve the quality of life and care for patients with a focus on gastrointestinal malignancies. Conclusion: We highlight patient-centered care delivery interventions, including patient-reported outcomes, hospital-at-home interventions, and other models of care for individuals with cancer. By demonstrating the relevance and utility of these different care models for patients with gastrointestinal malignancies, we hope to highlight the importance of developing and testing new interventions to address the unique needs of this population.
Feasibility of Quality of Life Assessment in Patients with Lymphoma Aged ≥80 Years Receiving Reduced-Intensity Chemotherapy: A Single-Institute Study
Authors: Yamasaki Satoshi
Published: December 2023

Quality of life (QOL) must be carefully monitored in older patients with lymphoma who are suitable for chemotherapy, but few reports have assessed QOL in older patients who received reduced-intensity chemotherapy. This study investigated QOL in patients with lymphoma aged ≥80 years to clarify the feasibility of such assessments following reduced-intensity chemotherapy. QOL was prospectively analyzed (using the QOL Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL-ACD)] and the SF-36®, a comprehensive survey of patient health) among 13 patients (seven women) aged ≥80 years with lymphoma who received reduced-intensity chemotherapy at 4-week intervals at Kyushu University Beppu Hospital between June 2022 and August 2023. Patients were assessed at baseline, in the middle of the protocol, at the end of the protocol, and 6 months after the end of the protocol. The overall response rate was 69%. Almost all severe adverse events (10 patients) occurred during early cycles (cycles 1–2). Common adverse events included hematological toxicities such as neutropenia (10 patients). The daily activity (p = 0.048) and social attitude (p = 0.027) scores of the QOL-ACD and the general health perception (p = 0.044) and social functioning (p = 0.030) scores of the SF-36® were significantly improved during and after chemotherapy. Reduced-dose chemotherapy, if implemented before treatment selection, might permit evaluations of QOL in older patients aged ≥80 years; further investigation is warranted.
Pan-Genome Analysis of TIFY Gene Family and Functional Analysis of CsTIFY Genes in Cucumber
Authors: Liu Kun , Xu Haiyu , Gao Xinbin , Lu Yinghao , Wang Lina , Ren Zhonghai , Chen Chunhua
Published: December 2023

Cucumbers are frequently affected by gray mold pathogen Botrytis cinerea, a pathogen that causes inhibited growth and reduced yield. Jasmonic acid (JA) plays a primary role in plant responses to biotic stresses, and the jasmonate-ZIM-Domain (JAZ) proteins are key regulators of the JA signaling pathway. In this study, we used the pan-genome of twelve cucumber varieties to identify cucumber TIFY genes. Our findings revealed that two CsTIFY genes were present in all twelve cucumber varieties and showed no differences in protein sequence, gene structure, and motif composition. This suggests their evolutionary conservation across different cucumber varieties and implies that they may play a crucial role in cucumber growth. On the other hand, the other fourteen CsTIFY genes exhibited variations in protein sequence and gene structure or conserved motifs, which could be the result of divergent evolution, as these genes adapt to different cultivation and environmental conditions. Analysis of the expression profiles of the CsTIFY genes showed differential regulation by B. cinerea. Transient transfection plants overexpressing CsJAZ2, CsJAZ6, or CsZML2 were found to be more susceptible to B. cinerea infection compared to control plants. Furthermore, these plants infected by the pathogen showed lower levels of the enzymatic activities of POD, SOD and CAT. Importantly, after B. cinerea infection, the content of JA was upregulated in the plants, and cucumber cotyledons pretreated with exogenous MeJA displayed increased resistance to B. cinerea infection compared to those pretreated with water. Therefore, this study explored key TIFY genes in the regulation of cucumber growth and adaptability to different cultivation environments based on bioinformatics analysis and demonstrated that CsJAZs negatively regulate cucumber disease resistance to gray mold via multiple signaling pathways.
Distinct Metabolic Profiles of Ocular Hypertensives in Response to Hypoxia
Authors: Langbøl Mia , Rovelt Jens , Saruhanian Arevak , Saruhanian Sarkis , Tiedemann Daniel , Baskaran Thisayini , Bocca Cinzia , Vohra Rupali , Cvenkel Barbara , Lenaers Guy , Kolko Miriam
Published: December 2023

Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role. The aim of the current study was to determine and compare the effect of universal hypoxia on the metabolomic signature in plasma samples from healthy controls (n = 10), patients with normal-tension glaucoma (NTG, n = 10), and ocular hypertension (OHT, n = 10). By subjecting humans to universal hypoxia, we aim to mimic a state in which the mitochondria in the body are universally stressed. Participants were exposed to normobaric hypoxia for two hours, followed by a 30 min recovery period in normobaric normoxia. Blood samples were collected at baseline, during hypoxia, and in recovery. Plasma samples were analyzed using a non-targeted metabolomics approach based on liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). Multivariate analyses were conducted using principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA), and univariate analysis using the Wilcoxon signed-rank test and false discovery rate (FDR) correction. Unique metabolites involved in fatty acid biosynthesis and ketone body metabolism were upregulated, while metabolites of the kynurenine pathway were downregulated in OHT patients exposed to universal hypoxia. Differential affection of metabolic pathways may explain why patients with OHT initially do not suffer or are more resilient from optic nerve degeneration. The metabolomes of NTG and OHT patients are regulated differently from control subjects and show dysregulation of metabolites important for energy production. These dysregulated processes may potentially contribute to the elevation of IOP and, ultimately, cell death of the RGCs.
Blockchain and Business Process Management (BPM) Synergy: A Comparative Analysis of Modeling Approaches
Authors: Taherdoost Hamed , Madanchian Mitra
Published: December 2023

Blockchain technology has become a powerful disruptive force that upends established ideas in several industries. A fascinating point of convergence is that of blockchain technology and Business Process Management (BPM), where the distributed and immutable characteristics of blockchain promise to completely transform the modeling, implementation, and oversight of business processes. This symbiosis offers a singular chance to develop corporate processes that are more efficient, safe, and transparent. Nevertheless, to guarantee that blockchain-specific components are accurately represented in these processes, modeling techniques need to be critically examined as part of integrating blockchain into BPM. This literature review examines blockchain-BPM integration using different modeling methodologies. Though well-established, traditional BPM approaches may need help with blockchain-specific aspects. Blockchain-oriented modeling includes smart contracts and decentralized consensus. Hybrid models with blockchain and traditional elements are popular. Adaptability, model clarity, and blockchain integration are evaluated in the analysis. This literature review aims to improve corporate processes’ efficiency, security, and transparency by investigating how to model the integration of blockchain and BPM better.
Machine Learning-Based Predictions for Half-Heusler Phases
Authors: Bilińska Kaja , Winiarski Maciej J.
Published: December 2023

Machine learning models (Support Vector Regression) were applied for predictions of several targets for 18-electron half-Heusler phases: a lattice parameter, a bulk modulus, a band gap, and a lattice thermal conductivity. The training subset, which consisted of 47 stable phases, was studied with the use of Density Functional Theory calculations with two Exchange-Correlation Functionals employed (GGA, MBJGGA). The predictors for machine learning models were defined among the basic properties of the elements. The most optimal combinations of predictors for each target were proposed and discussed. Root Mean Squared Errors obtained for the best combinations of predictors for the particular targets are as follows: 0.1 Å (lattice parameters), 11–12 GPa (bulk modulus), 0.22 eV (band gaps, GGA and MBJGGA), and 9–9.5 W/mK (lattice thermal conductivity). The final results of the predictions for a large set of 74 semiconducting half-Heusler compounds were disclosed and compared to the available literature and experimental data. The findings presented in this work encourage further studies with the use of combined machine learning and ab initio calculations.
Computed Tomography Angiography-Derived Scores for Prediction of Chronic Total Occlusion Percutaneous Coronary Intervention Using the Hybrid Algorithm
Authors: Zyśk Antoni , Wolny Rafał , Kruk Mariusz , Kwieciński Jacek , Dębski Artur , Barbero Umberto , Kępka Cezary , Demkow Marcin , Witkowski Adam , Opolski Maksymilian P.
Published: December 2023

Whereas coronary computed tomography angiography (CCTA) exceeds invasive angiography for predicting the procedural outcome of chronic total occlusion (CTO) percutaneous coronary intervention (PCI), CCTA-derived scores have never been validated in the hybrid CTO PCI population. In this single-center, retrospective, observational study, we included 108 consecutive patients with 110 CTO lesions and preprocedural CCTA who underwent hybrid CTO PCI to assess the diagnostic accuracy of CCTA-derived scoring systems. Successful guidewire crossing within 30 min was set as the primary endpoint. The secondary endpoints were final procedural success and the need for using any non-antegrade wiring (AW) strategy within the hybrid algorithm. Time-efficient guidewire crossing and final procedural success were achieved in 53.6% and 89.1% of lesions, respectively, while in 36.4% of the procedures, any non-AW strategy was applied. The median J-CTO score was 1 (interquartile range (IQR): 0, 2), while the CT-RECTOR, KCCT, J-CTOCCTA, and RECHARGECCTA scores were 2 (IQR: 1, 3), 3 (IQR: 2, 5), 1 (IQR: 0, 3), and 2 (IQR: 1, 3), respectively. All scores were significantly higher in the lesions with failed versus successful time-efficient guidewire crossing. Although all of the CCTA-derived scores had numerically higher predictive values than the angiographic J-CTO score, no significant differences were noted between the scores in any of the analyzed study endpoints. High sensitivity of the CT-RECTOR and RECHARGECCTA scores (both 89.8%) for predicting successful guidewire crossing within 30 min, and high sensitivity (90.8%) of the KCCT score for predicting final procedural success, were noted. CCTA-derived scoring systems are accurate, noninvasive tools for the prediction of the procedural outcome of hybrid CTO PCI, and may aid in identifying the need for use of the hybrid algorithm.
The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study
Authors: Rushiti Armina , Castellani Chiara , Cerrato Alessia , Fedrigo Marny , Sbricoli Luca , Bressan Eriberto , Angelini Annalisa , Bacci Christian
Published: December 2023

Human papilloma virus (HPV) is known as the main cause of cervical cancer. Data also indicate its role in head–neck cancer, especially oropharyngeal cancer. The correlation between high-risk HPV and oral cancer is still controversial. HPV-related lesions of the oral cavity are frequent and, in most cases, benign. The primary aim of this study was to establish if there is a different follow-up necessity between HPV-positive compared to HPV-negative oral lesions. The secondary aim was to evaluate the recurrence of HPV-related lesions. All patients who underwent a surgical procedure of oral biopsy between 2018 and 2022, with ulterior histopathological examination and HPV typing, were examined. A total of 230 patients were included: 75 received traumatic fibroma as diagnosis, 131 HPV-related lesions, 9 proliferative verrucous leukoplakia, and 15 leukoplakia. The frequency and period of follow-up varied in relation to HPV positivity and diagnosis. This study confirms what has already been reported by other authors regarding the absence of recommendations of follow-up necessity in patients with oral mucosal lesions. However, the data demonstrate that there was a statistically significant difference in the sample analyzed regarding the follow-up of HPV-positive vs. HPV-negative patients. It also confirms the low recurrence frequency of HPV-related oral lesions.
Adipose Tissue-Derived Minimally Manipulated Products versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence and Meta-Analysis
Authors: Veronesi Francesca , Andriolo Luca , Salerno Manuela , Boffa Angelo , Giavaresi Gianluca , Filardo Giuseppe
Published: December 2023

The use of minimally manipulated adipose tissue (MM-AT) products is gaining increasing interest for the treatment of knee osteoarthritis (OA). MM-AT represents an easy way to exploit adipose tissue properties, although clinical evidence is still limited, as well as their benefits with respect to more documented orthobiologics like platelet-rich plasma (PRP). A systematic review and meta-analysis were performed to evaluate the safety and efficacy of MM-AT products for knee OA management. The risk of bias of the included studies was evaluated using the Dawns and Black checklist for all the included studies and RoB-2.0 for randomized controlled trials (RCTs). Thirty-three clinical studies were included in the qualitative analysis: 13 prospective case series, 10 retrospective case series, 7 RCTs, 2 retrospective comparative studies, and 1 prospective comparative study. An overall clinical improvement and few minor adverse events were observed. Five RCTs comparing MM-AT and PRP injections were meta-analyzed, showing comparable results. The analysis also highlighted the limits of the literature, with only a few high-level trials and an overall low quality. Even though the current literature is still limited, the available evidence suggests the safety and overall positive results of the intra-articular injections of MM-AT products for knee OA treatment.
The Role of Renal PLA2R Staining Combined with Serum PLA2R Antibody in Membranous Nephropathy Risk Stratification
Authors: Hu Xiaofan , Wang Xinlu , Yu Xialian , Ni Liyan , Gao Chenni , Pan Xiaoxia , Ren Hong , Xu Jing , Ma Jun
Published: December 2023

Background: This study aimed to examine the clinicopathological profiles and prognosis of membranous nephropathy in different subtypes classified by serum PLA2R antibody (SAb) and glomerular PLA2R antigen staining (GAg). Methods: A total of 372 biopsy-proven membranous nephropathy (MN) cases, unrelated to lupus, with urine protein > 2 g/24 h and eGFR > 25 mL/min/1.73 m2 were included and categorized into four groups according to the presence or absence of PLA2R antibody and glomerular PLA2R antigen staining. Clinical profiles were compared among four subtypes. Treatment response and renal outcomes were compared among four groups with primary MN. Cox and logistic regression models were used to examine the association between time-to-renal progression and early remission within 6 months in the four subgroups with primary MN. Results: MN patients who were SAb−/GAg+ presented with a more severe disease onset, whereas those who were SAb−/GAg− had a mild clinical manifestation with a higher prevalence of MN-associated secondary causes. During a median follow-up of 79.2 months (IQR: 48.70–97.40), SAb+/GAg− was identified as an independent risk factor for renal progression [HR: 9.17, 95% CI: 2.26–37.16, p < 0.01] and early remission [OR: 0.06, 95% CI: 0.01–0.56, p = 0.01] in primary MN. Additionally, SAb−/GAg− with primary MN showed an independent association with spontaneous remission after adjusting for age, sex, baseline proteinuria, and eGFR (Before adjustment: OR: 8.33, 95% CI: 1.89–36.76, p = 0.0; after adjustment: OR: 12.25, 95% CI: 2.48–60.53, p < 0.01). Conclusion: Our findings indicated that SAb+/GAg−MN patients exhibited a more severe disease onset and had a poorer prognosis, necessitating an aggressive treatment approach. On the other hand, in the SAb−/GAg− group, the elimination of secondary causes should be considered, and a watchful waiting approach may be appropriate.
A New Methodology to Determine the Orifice for Root Canal Configurations in First Permanent Molar Root and Canal Morphologies Using Micro-Computed Tomography
Authors: Jonker Casper Hendrik , Lambourn Guy , Oettlé Anna Catherina , Foschi Federico , Theye Charlotte , L’Abbé Ericka Noelle
Published: December 2023

Background: The distinction between where the pulp chamber ends and the root canal system begins is poorly defined within the existing literature. Methods: This paper aimed to describe a range of accurate methods to define the transition from pulp chamber to root canal in different first molar root morphologies using micro-focus computed tomography (micro-CT). Methods: The sample consisted of 86 mandibular and 101 maxillary first molars from the skeletal collections housed in the Department of Anatomy and Histology of the Sefako Makgatho Health Sciences University and the Pretoria Bone Collection. A stepwise approach using the cemento–enamel junction (CEJ) and dedicated landmarks was followed to create an automated cross-sectional slice. Results: Transition from pulp chamber to root canal could be accurately determined on maxillary and mandibular teeth. The occurrence of two separate roots in mandibular molars was 97.7%, with the remaining 2.3% having an additional disto-lingual root, with no mandibular molars displaying fused roots. In the maxillary molars, 92.1% had three separate roots and 7.9% displayed root fusion. Within this group, one tooth displayed a C-shaped root canal configuration and one a mesotaurodont-type morphology. Conclusion: The suggested methodology to determine orifice location was found to be appropriate in all morphological types.
Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications
Authors: Timofticiuc Iosif-Aliodor , Călinescu Octavian , Iftime Adrian , Dragosloveanu Serban , Caruntu Ana , Scheau Andreea-Elena , Badarau Ioana Anca , Didilescu Andreea Cristiana , Caruntu Constantin , Scheau Cristian
Published: December 2023

Along with the rapid and extensive advancements in the 3D printing field, a diverse range of uses for 3D printing have appeared in the spectrum of medical applications. Vat photopolymerization (VPP) stands out as one of the most extensively researched methods of 3D printing, with its main advantages being a high printing speed and the ability to produce high-resolution structures. A major challenge in using VPP 3D-printed materials in medicine is the general incompatibility of standard VPP resin mixtures with the requirements of biocompatibility and biofunctionality. Instead of developing completely new materials, an alternate approach to solving this problem involves adapting existing biomaterials. These materials are incompatible with VPP 3D printing in their pure form but can be adapted to the VPP chemistry and general process through the use of innovative mixtures and the addition of specific pre- and post-printing steps. This review’s primary objective is to highlight biofunctional and biocompatible materials that have been adapted to VPP. We present and compare the suitability of these adapted materials to different medical applications and propose other biomaterials that could be further adapted to the VPP 3D printing process in order to fulfill patient-specific medical requirements.
Benthic Foraminifera as Proxies of Paleoenvironmental Changes in the Sant’Elia-Foxi Canyon (Gulf of Cagliari, Italy, Western Tyrrhenian Sea)
Authors: Cristallo Carla , Buosi Carla , Francescangeli Fabio , Bouchet Vincent M. P. , Schirone Antonio , Tamburrino Stella , Frontalini Fabrizio
Published: December 2023

Marine coastal areas are highly dynamic and fragile environments characterised by a complex interplay of biological, physical, and chemical factors. These areas are also affected by anthropogenic activities with the discharge of organic and inorganic contaminants that alters the quality of the environment. In this work, the effects of anthropogenic activities (i.e., urban and industrial development) on benthic foraminifera have been investigated along the A2TM core collected from the Sant’Elia-Foxi Canyon (Gulf of Cagliari, Sardinia—western Tyrrhenian Sea). The Gulf of Cagliari has experienced intense urbanisation since the beginning of the twentieth century with the establishment of petrochemical complexes and harbour activities. The A2TM core, dating from 1907 to 2013, was analysed with an integrated approach that includes grain size, organic matter, and benthic foraminifera characterisation compared with geochemical characterisation. The variations in the composition of the benthic foraminiferal assemblages and the Margalef diversity index are related to the altered environmental conditions that reflect the historical development of the area and to the land-based activities surrounding the Gulf of Cagliari. The statistical analysis identifies two main intervals (i.e., the years 1907–1986 and 1986–2013) that are typified by different benthic foraminiferal assemblages and diversity values. Accordingly, the increases in organic matter content and both organic and inorganic contaminants are well mirrored by a major drop in foraminiferal diversity after 1973 and a major foraminiferal turnover after 1989. The composition of the benthic foraminiferal assemblages in the uppermost part of the core (i.e., 1989–2013) might suggest a lowering of the oxygen availability at the seafloor. These changes might be related to the increase in organic matter and the silty fraction in the same interval likely triggered by damming on land and wetland reclamation.
A Review of CO2 Plume Dispersion Modeling for Application to Offshore Carbon Capture and Storage
Authors: Kim Yong-Hoon , Park Young-Gyu
Published: December 2023

The exponential increase in greenhouse gas emissions necessitates urgent measures to mitigate climate change impacts. Carbon capture and storage (CCS) has emerged as a promising solution, capturing CO2 from industrial processes and storing it underground. However, CCS implementation poses risks that demand sophisticated modeling. This review focuses on the numerical modeling of CO2 plume dispersion from reservoir leaks during offshore CCS projects, including near- and far-field modeling and the comparison between Lagrangian and Eulerian modeling in particular. Near-field modeling examines CO2 behavior in jet plume, considering depth-related changes. Far-field modeling, employing Eulerian and Lagrangian methods, evaluates dispersion in marine environments. Case studies illustrate the complexity and uniqueness of CO2 dispersion events. The Lagrangian approach emphasizes gas bubble tracking, while the Eulerian approach employs fixed grid systems for detailed hydrodynamic modeling. Both approaches contribute valuable insights, with Eulerian models excelling in site-specific complexities and Lagrangian models offering computational efficiency. A hybrid approach may offer a comprehensive understanding of CO2 dispersion.
Benzalkonium Chloride and Benzethonium Chloride Effectively Reduce Spore Germination of Ginger Soft Rot Pathogens: Fusarium solani and Fusarium oxysporum
Authors: Zhao Dongxu , Zhang Yang , Jin Zhaoyang , Bai Ruxiao , Wang Jun , Wu Li , He Yujian
Published: December 2023

Ginger soft rot is a serious soil-borne disease caused by Fusarium solani and Fusarium oxysporum, resulting in reduced crop yields. The application of common chemical fungicides is considered to be an effective method of sterilization, and therefore, they pose a serious threat to the environment and human health due to their high toxicity. Benzalkonium chloride (BAC) and benzethonium chloride (BEC) are two popular quaternary ammonium salts with a wide range of fungicidal effects. In this study, we investigated the fungicidal effects of BAC and BEC on soft rot disease of ginger as alternatives to common chemical fungicides. Two soft rot pathogens of ginger were successfully isolated from diseased ginger by using the spread plate method and sequenced as F. solani and F. oxysporum using the high-throughput fungal sequencing method. We investigated the fungicidal effects of BAC and BEC on F. solani and F. oxysporum, and we explored the antifungal mechanisms. Almost complete inactivation of spores of F. solani and F. oxysporum was observed at 100 mg/L fungicide concentration. Only a small amount of spore regrowth was observed after the inactivation treatment of spores of F. solani and F. oxysporum in soil, which proved that BAC and BEC have the potential to be used as an alternative to common chemical fungicides for soil disinfection of diseased ginger.
Association between Tonsillectomy and Cardiovascular Diseases in Adults
Authors: Park Sung Joon , Lee Sei Young , Jung Hahn Jin , Park Min Woo , Choi Hyo Geun , Kim Heejin , Wee Jee Hye
Published: December 2023

This study aimed to evaluate the association between tonsillectomy and cardiovascular diseases (CVDs) in the Korean adult population. Using data from the 2002–2015 Korean National Health Insurance Service-Health Screening Cohort, a total of 1082 participants aged 40 years or older who had undergone tonsillectomy were matched with 4328 control individuals for age, sex, income, and region of residence. We evaluated the incidence of CVDs in both the tonsillectomy and control groups and calculated the hazard ratios (HRs) of stroke, ischemic heart disease (IHD), and heart failure (HF) for participants who underwent tonsillectomy using a stratified Cox proportional hazard model. The incidence rates of stroke (81.3 vs. 46.6 per 10,000 person-years) and IHD (112.3 vs. 64.9 per 10,000 person-years) were significantly higher in patients who had undergone tonsillectomy than in the control group. After adjustment, the tonsillectomy group exhibited a 1.78-fold and 1.60-fold higher occurrence of stroke (CI = 1.32–2.42, p < 0.001) and IHD (CI = 1.24–2.08, p < 0.001), respectively, compared to the control group. However, there was no significant difference in the incidence rate of tonsillectomy and control groups (11.1 vs. 6.1 per 10,000 person-years). The HR of HF did not differ significantly between the tonsillectomy and control groups in the adjusted model (p = 0.513). We identified a significant relationship between a history of tonsillectomy and occurrence of stroke/IHD in the Korean adult population.
Tyrosine Kinase Inhibitors for Radioactive Iodine Refractory Differentiated Thyroid Cancer
Authors: Cortas Christos , Charalambous Haris
Published: December 2023

Patients with differentiated thyroid cancer usually present with early-stage disease and undergo surgery followed by adjuvant radioactive iodine ablation, resulting in excellent clinical outcomes and prognosis. However, a minority of patients relapse with metastatic disease, and eventually develop radioactive iodine refractory disease (RAIR). In the past there were limited and ineffective options for systemic therapy for RAIR, but over the last ten to fifteen years the emergence of tyrosine kinase inhibitors (TKIs) has provided important new avenues of treatment for these patients, that are the focus of this review. Currently, Lenvatinib and Sorafenib, multitargeted TKIs, represent the standard first-line systemic treatment options for RAIR thyroid carcinoma, while Cabozantinib is the standard second-line treatment option. Furthermore, targeted therapies for patients with specific targetable molecular abnormalities include Latrectinib or Entrectinib for patients with NTRK gene fusions and Selpercatinib or Pralsetinib for patients with RET gene fusions. Dabrafenib plus Trametinib currently only have tumor agnostic approval in the USA for patients with BRAF V600E mutations, including thyroid cancer. Redifferentiation therapy is an area of active research, with promising initial results, while immunotherapy studies with checkpoint inhibitors in combination with tyrosine kinase inhibitors are underway.
Traditional Therapeutics and Potential Epidrugs for CVD: Why Not Both?
Authors: Gladwell Lauren Rae , Ahiarah Chidinma , Rasheed Shireen , Rahman Shaikh Mizanoor , Choudhury Mahua
Published: December 2023

Cardiovascular disease (CVD) is the leading cause of death worldwide. In addition to the high mortality rate, people suffering from CVD often endure difficulties with physical activities and productivity that significantly affect their quality of life. The high prevalence of debilitating risk factors such as obesity, type 2 diabetes mellitus, smoking, hypertension, and hyperlipidemia only predicts a bleak future. Current traditional CVD interventions offer temporary respite; however, they compound the severe economic strain of health-related expenditures. Furthermore, these therapeutics can be prescribed indefinitely. Recent advances in the field of epigenetics have generated new treatment options by confronting CVD at an epigenetic level. This involves modulating gene expression by altering the organization of our genome rather than altering the DNA sequence itself. Epigenetic changes are heritable, reversible, and influenced by environmental factors such as medications. As CVD is physiologically and pathologically diverse in nature, epigenetic interventions can offer a ray of hope to replace or be combined with traditional therapeutics to provide the prospect of addressing more than just the symptoms of CVD. This review discusses various risk factors contributing to CVD, perspectives of current traditional medications in practice, and a focus on potential epigenetic therapeutics to be used as alternatives.
Inclusion Bodies in Ionic Liquids
Authors: Szabadi András , Klausser Robert , Spadiut Oliver , Schröder Christian
Published: December 2023

The pivotal role of proteins in pharmaceuticals is challenged by stability issues, making the study of inclusion bodies—a source of insoluble protein aggregates—increasingly relevant. This review outlines the critical procedures in inclusion body processing, focusing on ’mild solubilization concepts’ and refolding methodologies. Attention is afforded to the emerging role of ionic liquids with unique and tunable physicochemical properties in optimizing protein unfolding and refolding processes. The review critically assesses the existing literature at the intersection of inclusion bodies and ionic liquids, identifying recent advancements, potential applications, and avenues for future research. This comprehensive analysis aims to elucidate the complexities in efficient protein processing from inclusion bodies.
N,N′-Dipropyloxamide
Authors: Podda Enrico , Dodd Eleanor , Arca Massimiliano , Aragoni M. Carla , Lippolis Vito , Coles Simon J. , Pintus Anna
Published: December 2023

N,N′-Dipropyloxamide (1) was synthesised by the reaction between diethyloxalate and n-propylamine in ethanol. Compound 1 was fully characterised by both microanalytical (elemental analysis, melting point determination) and spectroscopic means (FT-IR and NMR spectroscopy). Crystals suitable for single crystal X-ray diffraction were isolated by the slow evaporation of a methyl alcohol solution of the compound. The resulting crystal structure shows the prominent role exerted by intermolecular hydrogen bonds in the crystal packing.
Multi-Agent Reinforcement Learning for Extended Flexible Job Shop Scheduling
Authors: Peng Shaoming , Xiong Gang , Yang Jing , Shen Zhen , Tamir Tariku Sinshaw , Tao Zhikun , Han Yunjun , Wang Fei-Yue
Published: December 2023

An extended flexible job scheduling problem is presented with characteristics of technology and path flexibility (dual flexibility), varied transportation time, and an uncertain environment. The scheduling can greatly increase efficiency and security in complex scenarios, e.g., distributed vehicle manufacturing, and multiple aircraft maintenance. However, optimizing the scheduling puts forward higher requirements on accuracy, real time, and generalization, while subject to the curse of dimension and usually incomplete information. Various coupling relations among operations, stations, and resources aggravate the problem. To deal with the above challenges, we propose a multi-agent reinforcement learning algorithm where the scheduling environment is modeled as a decentralized partially observable Markov decision process. Each job is regarded as an agent that decides the next triplet, i.e., operation, station, and employed resource. This paper is novel in addressing the flexible job shop scheduling problem with dual flexibility and varied transportation time in consideration and proposing a double Q-value mixing (DQMIX) optimization algorithm under a multi-agent reinforcement learning framework. The experiments of our case study show that the DQMIX algorithm outperforms existing multi-agent reinforcement learning algorithms in terms of solution accuracy, stability, and generalization. In addition, it achieves better solution quality for larger-scale cases than traditional intelligent optimization algorithms.
Recycling Pricing and Government Subsidy Strategy for End-of-Life Vehicles in a Reverse Supply Chain under Consumer Recycling Channel Preferences
Authors: Wang Zhiguo
Published: December 2023

In the existing recycling system for end-of-life vehicles (ELVs), online recycling based on the Internet platform is a useful supplement. In this paper, a Stackelberg game pricing model, which is dominated by ELV part remanufacturers and composed of remanufacturers, recyclers, and consumers, is constructed considering consumer preferences for recycling channels. The influence of different subsidy strategies on the optimal pricing, profit, and recycling volume of the reverse supply chain (RSC) of ELVs is discussed, and the effects of factors such as subsidy amount and consumer preferences on the RSC of ELVs are analyzed using numerical simulation. The results show that the increase in consumers’ online recycling preferences has a positive effect on the recycling volume and profit of the RSC of ELVs. Considering the recycling volume of the RSC, when fewer subsidies are given, more recycling volume can be generated by subsidizing remanufacturers, and, on the contrary, recycling volume will be generated by subsidizing consumers. Considering the profit of the RSC, when subsidies are given at the lower-middle level, higher profits can be earned by subsidizing remanufacturers, and, on the contrary, higher profits can be earned by subsidizing consumers.
Spectral Decomposition of Gramians of Continuous Linear Systems in the Form of Hadamard Products
Authors: Yadykin Igor
Published: December 2023

New possibilities of Gramian computation, by means of canonical transformations into diagonal, controllable, and observable canonical forms, are shown. Using such a technique, the Gramian matrices can be represented as products of the Hadamard matrices of multipliers and the matrices of the transformed right-hand sides of Lyapunov equations. It is shown that these multiplier matrices are invariant under various canonical transformations of linear continuous systems. The modal Lyapunov equations for continuous SISO LTI systems in diagonal form are obtained, and their new solutions based on Hadamard decomposition are proposed. New algorithms for the element-by-element computation of Gramian matrices for stable, continuous MIMO LTI systems are developed. New algorithms for the computation of controllability Gramians in the form of Xiao matrices are developed for continuous SISO LTI systems, given by the equations of state in the controllable and observable canonical forms. The application of transformations to the canonical forms of controllability and observability allowed us to simplify the formulas of the spectral decompositions of the Gramians. In this paper, new spectral expansions in the form of Hadamard products for solutions to the algebraic and differential Sylvester equations of MIMO LTI systems are obtained, including spectral expansions of the finite and infinite cross - Gramians of continuous MIMO LTI systems. Recommendations on the use of the obtained results are given.
New Spinal Shortening Technique for Tethered Cord Syndrome: A Technical Note
Authors: Tanaka Masato , Sonawane Sumeet , Arataki Shinya , Fujiwara Yoshihiro , Taoka Takuya , Uotani Koji , Oda Yoshiaki , Shinohara Kensuke
Published: December 2023

Background and Objectives: To present a new spinal shortening technique for tethered cord syndrome. Tethered cord syndrome (TCS) is a debilitating condition leading to progressive neurological decline. Surgical detethering for TCS is the gold standard of treatment. However, symptomatic retethering of TCS has been reported in 5%–50% of patients after initial release. To solve this problem, posterior spinal shortening osteotomy has been reported. This technique has risks of massive blood loss and neurological deterioration. The authors hereby report a new safe spinal shortening technique for tethered cord syndrome. Materials and Methods: A 31-year-old man with gait disturbance was referred to our hospital. After the delivery of treatment, he underwent surgical untethering of the spinal cord in another hospital. He had hyperreflexia of the Achilles tendon reflex and bilateral muscle weakness of the legs (MMT 3-4). He also had urinary and bowel incontinence, and total sensory loss below L5. An anteroposterior lumbar radiogram indicated partial laminectomy of L3 and L4. Lumbar MRI showed retethering of spinal cord. Results: The patient underwent a new spinal shortening technique for tethered cord syndrome under the guidance of O-arm navigation. First, from the anterior approach, disectomy from T12 to L3 was performed. Second, from the posterior approach, Ponte osteotomy was performed from T12 to L3, shortening the spinal column by 15 mm. The patient was successfully treated surgically. Postoperative lumbar MRI showed that the tension of the spinal cord was released. Manual muscle testing results and the sensory function of the left leg had recovered almost fully upon final follow-up at one year. Conclusions: A retethered spinal cord after initial untethering is difficult to treat. This new spinal shortening technique can represent another good option to release the tension of the spinal cord.
Atopic March or Atopic Multimorbidity—Overview of Current Research
Authors: Mrkić Kobal Iva , Plavec Davor , Vlašić Lončarić Željka , Jerković Ivana , Turkalj Mirjana
Published: December 2023

The atopic march encompasses a sequence of allergic conditions, including atopic dermatitis, food allergy, allergic rhinitis, and asthma, that frequently develop in a sequential pattern within the same individual. It was introduced as a conceptual framework aimed at elucidating the developmental trajectory of allergic conditions during childhood. Following the introduction of this concept, it was initially believed that the atopic march represented the sole and definitive trajectory of the development of allergic diseases. However, this perspective evolved with the emergence of new longitudinal studies, which revealed that the evolution of allergic diseases is far more intricate. It involves numerous immunological pathological mechanisms and may not align entirely with the traditional concept of the atopic march. The objective of our review is to portray the atopic march alongside other patterns in the development of childhood allergic diseases, with a specific emphasis on the potential for a personalized approach to the prevention, diagnosis, and treatment of atopic conditions.
Dynamics Management of Intermediate Water Storage in an Air-Breathing Single-Cell Membrane Electrode Assembly
Authors: Kumar Avinash , Schechter Alex , Avrahami Idit
Published: December 2023

In air-breathing proton exchange membrane fuel cells (Air PEM FCs), a high rate of water evaporation from the cathode might influence the resistance of the membrane electrode assembly (MEA), which is highly dependent on the water content of the Nafion membrane. We propose a dead-end hydrogen anode as a means of intermediate storage of water/humidity for self-humidification of the membrane. Such an inflatable bag integrated with a single lightweight MEA FC has the potential in blimp applications for anode self-humidification. A dynamic numerical water balance model, validated by experimental measurements, is derived to predict the effect of MEA configuration, and the membrane’s hydration state and water transfer rate at the anode on MEA resistance and performance. The experimental setup included humidity measurements, and polarization and electrochemical impedance spectroscopy tests to quantify the effect of membrane hydration on its resistance in a lightweight MEA (12 g) integrated with an inflatable dead-end hydrogen storage bag. Varying current densities (5, 10, and 15 mA/cm2) and cathode humidity levels (20, 50, and 80%) were examined and compared with the numerical results. The validated model predicts that the hydration state of the membrane and water transfer rate at the anode can be increased by using a thin membrane and thicker gas diffusion layer.