bluuebunny/crossref_metadata_2025 huggingface dataset:
Indwelling without the indwelling Holy Spirit: a critique of Ray Yeo’s modified account
Authors: Kroll Kimberley
Published: July 2019

In 2014, Ray Yeo published a modified account of the Spirit’s indwelling in “Towards a Model of the Indwelling: A Conversation with Jonathan Edwards and William Alston.” Yeo utilizes a conglomerate of Two-Minds Christology and Spirit Christology to provide a metaphysical framework for his model which he believes offers a viable alternative to more traditional merger accounts like those of Edwards and Alston. After providing an overview of Yeo’s objections to the merger accounts of Alston and Edwards, I will summarize Yeo’s modified model. I will argue Yeo’s emphasis on the humanity of Christ in lieu of a literal, internal, and direct union of the Holy Spirit and the human person cannot alleviate the core metaphysical concerns which surface in all accounts of union between the divine and human.  Yeo’s misunderstanding of Two-Minds Christology leads him to deny the full humanity of Christ; a humanity upon which his entire account of the indwelling relies. Yeo’s modified model will be shown unsuccessful as an account of the indwelling of the Holy Spirit even if one accepts both his conception of Two-Minds Christology and his conditions for indwelling.
Planificar el territorio desde el paisaje
Authors: Birche Arq. Mariana , Jensen Arq. Karina
Published: July 2019

Para abordar la presente investigación se parte de comprender al paisaje como el resultado de la interacción entre el hombre y la naturaleza. Se propone realizar un análisis sobre la estructura formal del paisaje en el Gran La Plata, entendiendo al paisaje como factor clave para la ordenación territorial. La metodología adoptada parte de elaborar un primer diagnóstico de la región para identificar los distintos tipos de usos de suelo y la superficie de ampliación del área urbana en las últimas tres décadas. En una segunda instancia, se elaborará una síntesis del diagnóstico urbano-territorial y se determinarán los tipos de paisaje identificados en el área de estudio, permitiendo de esta manera elaborar un diagnóstico de paisaje que contemple la problemática de la expansión del área urbana. Finalmente, se desarrolla una tercer etapa que incluye estrategias y lineamientos que posicionarían más eficientemente al área de estudio frente a las nuevas tendencias de crecimiento que exigen a las ciudades un desarrollo urbano más sustentable. En este sentido, el conocimiento sobre el paisaje debe apuntar a la acción, a frenar la pérdida de identidad y calidad paisajística, abocándose a identificar e impulsar desde un enfoque interdisciplinar los valores y las características del paisaje.
Aktualisasi Prinsip Continuous Improvement dalam Kepemimpinan Responsif Kepala PAUD Islam Terpadu al-Ikhlas Bumiayu Brebes
Authors: Wiyani Novan Ardy
Published: July 2019

This descriptive qualitative research is intended to obtain a description of the actualization of the continuous improvement principle in responsive leadership, the head of the Islamic Integrated Islamic Education Institute of Al-Ikhlas, Bumiayu District, Brebes Regency. The data in this study were collected using interview, observation, and documentation techniques. The author uses the data source triangulation technique to obtain valid research data. Valid research data are then analyzed using inductive data analysis techniques. The results showed that the actualization of the principle of continuous improvement in responsive leadership of the head of the Islamic PAUD Integrated al-Ikhlas in the Bumiayu sub-district of Brebes district was carried out by implementing six steps. First, diagnose problems in the implementation of integrated PAUD programs. Second, formulate solutions to problems in the implementation of integrated PAUD programs. Third, develop an improvement plan to overcome problems in the implementation of integrated PAUD programs. Fourth, condition resources to overcome problems in the implementation of integrated PAUD programs. Fifth, implement an improvement plan to overcome problems in the implementation of integrated PAUD programs. Sixth, evaluate the results of improvements to overcome problems in the implementation of integrated PAUD programs.
تعليم القواعد النحوية: بين المشاكل والحل
Authors: Khitam Achmad Khusnul
Published: July 2019

As we know that the problem of teaching Arabic is still considered as one of the most fundamental issues, not only for those who speak Arabic but also for the children of this language. As for grammar, it is the most educated and incomprehensible since it has many rules that relate to each other. Students with this difficulty have claimed that these hard rules can not be understood with the teacher's weakness in applying a good way to defend their jealousy. This research aims at searching for teaching grammatical rules and then completing it by mentioning some of the problems that students faced in learning and how to solve them with explaining the truth of education first and the grammar with a brief explanation. It is understood from this research that students face many problems in learning the Arabic language, including the abundance of language laws, the many different aspects of Circumcision, the multiplicity of mixed mabahith, and others. The solution that students and teachers can use is a lot of training, purification, and simplification of grammar, and so on.
Pembelajaran Mahārat al-Kalām Menurut Rusdy Ahmad Thu’aimah dan Mahmud Kamil al-Nâqah
Authors: Hady Yazid
Published: July 2019

Many experts about Arabic argue about the nature of language which will have an impact on the pattern of learning Arabic, including that اللغة في الأساس, هي الكلام” According to Mahmud Kamil al-Nâqah the urgency of speaking skills in the context of learning foreign languages ​​is found in the oral aspects of the language itself. The speaking aspect is the main aspect of the foreign language learning curriculum. This opinion clearly indicates that speaking skills (kalām) indicate a person's success in speaking and knowing the language. Because this proficiency is very much related to pronunciation, grammar, vocabulary, listening skills, etc. This research uses descriptive analysis method, and the conclusions obtained based on this research are curriculum design for learning Arabic based on mahārat al-kalām learning theory according to Rusdy Ahmad Thu'aimah and Mahmud Kamil al-Nâqah. Then the use of methods and strategies or techniques based on the right approach will influence the results of language learning goals. The purpose of this study is to analyze the learning of mahārat al-kalām according to Rusdy Ahmad Thu’aimah and Mahmud Kamil al-Nâqah.

Abstrak

Banyak para ahli tentang bahasa Arab berpendapat tentang hakikat berbahasa yang akan berdampak pada pola pembelajaran bahasa Arab, diantaranya bahwa  “اللغة في الأساس, هي الكلام”. Menurut Mahmud Kamil al-Nâqah urgensi kemahiran berbicara dalam konteks pembelajaran bahasa Asing terdapat pada aspek lisan pada bahasa itu sendiri. Aspek berbicara merupakan aspek utama dalam kurikulum pembelajaran bahasa Asing. Pendapat ini jelas mengindikasikan bahwa kemahiran berbicara (kalām) mengisyaratkan keberhasilan seseorang dalam berbahasa dan mengetahui bahasa tersebut. Karena kemahiran ini sangat terkait dengan pelafalan, gramatika, kosakata, keterampilan mendengarkan, dan lain lain. Penelitian ini menggunakan metode analisis deskriptif, dan kesimpulan yang didapatkan berdasarkan penelitian ini berupa desain kurikulum pembelajaran bahasa Arab berdasarkan teori pembelajaran mahārat al-kalām menurut Rusdy Ahmad Thu’aimah dan Mahmud Kamil al-Nâqah. Maka Penggunaan metode dan strategi atau teknik yang didasari oleh pendekatan (approach) yang tepat akan berpengaruh terhadap hasil dari tujuan pembelajaran bahasa. Tujuan dari penelitian ini adalah menganalisis pembelajaran mahārat al-kalām menurut Rusdy Ahmad Thu’aimah dan Mahmud Kamil al-Nâqah.

Kata kunci: Pembelajaran Bahasa Arab, mahārah kalām, Rusdy Ahmad Thu’aimah, Mahmud Kamil al-Nâqah.
Eksperimentasi Metode Mind Map pada Pembelajaran Nahwu Bahasa Arab untuk Meningkatkan Hasil Belajar Siswa
Authors: Seena Endah , Nashirudin
Published: July 2019

تهدف هذا البحث لمعرفة فرق إنجازات التعليم الكبير بين الفصل التجريبى الذي يستخدمها و الفصل الضابط الذي لا يستخدمها. كان البحث بحثا تجريبيّا وتصميم مجموعة مراقبة الإختبار القبلي و الإختبار البعدي (control group pretest-posttest design). والتحليل بياناته باستخدام اختبار “t” بمساعدة SPSS 16.0. تشير نتائج هذا البحث إلى أن: (۱) يبدأ تطبيق طريقة Mind Map فى الصفّ الثامن أ بالتوضيح عن تسليم المادة و عن تعريف طريقة Mind Map مثالها و نظامها و خطوات صنعها. فى هذه الأنشطة تكون الطلبة يجعلون Mind Map عن المادة جماعيا و يرسل كل المجموعات وكيلا واحدا لشرح Mind Map أمام الفصل. ينعكس المعلم و يخلص المادة فى أخير الدرس. (٢) وجود الفرق الكبير فى إنجازات تعليم الطلبة بين الفصل الذي يستخدم طريقة Mind Map   و الفصل الذي لا يستخدمها. يمكن نظر هذا الفرق من قيمة اختبار "t". تشير نتائج الاختبار القبلي و الاختبار البعدي إلى أن  = 0.000(2-tailed)Sig. (مقبولHa ). زيادة القيمة المتوسطة للاختبار البعدي فى الفصل التجريبي تحصل على ۷۵.۳٨ بينما فى الفصل الضابط تحصل على ۱٢.۳ من جميع نتائج تحليل البيانات يمكن تخليصها أن طريقة (Mind Map) تستطيع أن ترقي إنجازة تعليم اللغة العربيّة عن النحو.

Abstrak

Tujuan dilaksanakan penelitian ini adalah untuk mengetahui perbedaan hasil belajar yang signifikan antara kelas eksperimen dan kelas control belajar nahwu bahasa Arab yang menggunakan metode mind map dengan yang tidak menggunakan metode mind map. Penelitian ini merupakan penelitian eksperimen dengan desain penelitian control group pretest-posttest design. Subjek penelitian ini adalah kelas VIII A sebagai kelas eksperimen dan kelas D sebagai kelas kontrol. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan antara hasil belajar nahwu bahasa Arab yang menggunakan metode mind map dengan yang tidak menggunakan metode mind map. Hal tersebut terlihat pada uji “t” nilai pretest dan posttest kelas eksperimen menunjukkan nilai sig. (2-tailed) = 0.000 (Ha diterima). Peningkatan nilai rata-rata posttest kelas eksperimen mencapai 38.75 point, sedangkan kelas kontrol hanya mengalami peningkatan nilai rata-rata posttest sebesar 3.12 point. Dari hasil analisis tersebut dapat disimpulkan bahwa metode mind map dapat meningkatkan hasil belajar nahwu bahasa Arab.

Kata Kunci: Metode Mind Map, Nahwu, Hasil Belajar.
Elecsys® and Kryptor immunoassays for the measurement of sFlt-1 and PlGF to aid preeclampsia diagnosis: are they comparable?
Authors: Stepan Holger , Hund Martin , Dilba Peter , Sillman Johanna , Schlembach Dietmar
Published: July 2019

Background

For pregnant women with suspected preeclampsia, the soluble fms-like tyrosine-kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio is a biomarker to aid diagnosis. We performed method comparisons between Elecsys® and Kryptor sFlt-1 and PlGF immunoassays and assessed the diagnostic performance for preeclampsia.

Methods

Serum samples from a case-control study involving 113 pregnant women with preeclampsia/elevated liver enzymes and low platelet count (HELLP) and 270 controls were analyzed. sFlt-1 and PlGF were measured using Roche Elecsys® and BRAHMS Kryptor sFlt-1/PlGF immunoassays. The sFlt-1/PlGF ratios were calculated, and Passing-Bablok regression/Bland-Altman plots were performed. Gestation-specific cut-offs, ≤33 and ≥85/≥110, were assessed.

Results

Mean (±2 standard deviation [SD]) differences between the Elecsys® and Kryptor values were: sFlt-1, 173.13 pg/mL (6237.66, −5891.40); PlGF, −102.71 pg/mL (186.06, −391.48); and sFlt-1/PlGF, 151.74 (1085.11, −781.63). The Elecsys® and Kryptor immunoassays showed high correlation: Pearson’s correlation coefficients were 0.913 (sFlt-1) and 0.945 (PlGF). Slopes were 1.06 (sFlt-1) and 0.79 (PlGF), resulting in ~20% lower values for Kryptor PlGF. Sensitivities and specificities using the sFlt-1/PlGF ≥85 cut-off for early-onset preeclampsia (20 + 0 to 33 + 6 weeks) were 88.1%/100.0% (Elecsys®) and 90.5%/96.2% (Kryptor), respectively, and using the ≥110 cut-off for late-onset preeclampsia (≥34 + 0 weeks) were 51.3%/96.5% (Elecsys®) and 78.9%/90.1% (Kryptor), respectively. Using Elecsys® and Kryptor sFlt-1/PlGF, 0% and 3.8% of women, respectively, were falsely ruled-in for early-onset, and 3.5% and 9.9%, respectively, for late-onset preeclampsia.

Conclusions

Despite high correlation between the Elecsys® and Kryptor immunoassays, we observed significant differences between sFlt-1/PlGF and PlGF results. Therefore, sFlt-1/PlGF cut-offs validated for Elecsys® immunoassays are not transferable to Kryptor immunoassays.
Impact of Different Packaging Systems on Selected Antioxidant Properties of Frozen-Stored Broccoli
Authors: Kapusta-Duch Joanna , Leszczyńska Teresa , Borczak Barbara , Florkiewicz Adam , Ambroszczyk Anna
Published: July 2019

Broccoli has a very good nutritive value, high antioxidant activity and pro-healthy potential. Freezing is one of best methods for vegetable storage and broccoli belongs to the group of vegetables subjected to this process on an industrial scale. This work investigates the effect of type of container: low density polyethylene (PE-LD) bags and oriented polystyrene (OPS) boxes on selected quality parameters in frozen broccoli. The experimental material was the broccoli cultivar Lord

F1. The vegetable was subjected to blanching, freezing and 3-month storage. At the every stage of an experiment the material was examined in terms of: vitamin C content; β-carotene; total polyphenols; and antioxidant potential, which was determined basing on the ability to quench the ABTS˙
+ free radical. It has been found that vegetables which were kept frozen for 3 months in two types of container had parallel levels of vitamin C, β-carotene; total polyphenols; and similar antioxidative potential.
Start low, go slowly – mental abnormalities in young prolactinoma patients under cabergoline therapy
Authors: Brichta Corinna Melanie , Wurm Michael , Krebs Andreas , Schwab Karl Otfried , van der Werf-Grohmann Natascha
Published: July 2019

Background

Prolactin-secreting pituitary adenomas in childhood and adolescence are rare. First-line therapy consists of dopamine agonists (DAs) like cabergoline. Experience in treating prolactinomas in paediatric and adolescent patients is limited.

Methods

This study was a retrospective analysis of clinical data, laboratory data, radiological findings and medical treatment of paediatric and adolescent patients with prolactinomas between 2009 and 2018.

Results

Our cohort of nine patients had a median age at diagnosis of 13 years (range 5–17). Main presenting symptoms were weight gain, disorders of the pituitary-gonadal axis and headache. Treatment with cabergoline resulted in a marked reduction in prolactin concentration in all nine patients. Tumour mass reduction was confirmed by magnetic resonance imaging (MRI) scan in seven patients. Noteworthy is that cabergoline therapy triggered frequent adverse effects in a total of eight patients – seven of whom suffered from mental disorders, five of whom had neurological symptoms and five of whom had gastrointestinal problems. The adverse effects occurred at a median dose of only 0.5 mg/week (range 0.25–2.0). Most symptoms were alleviated after the cabergoline dose was lowered. Therapy discontinuation was not necessary in any patient.

Conclusions

Cabergoline effectively lowers prolactin levels and may reduce tumour mass in paediatric and adolescent patients with prolactinomas. Potential adverse effects may include mental disorders and behavioural problems even at low cabergoline doses. Low starting doses and careful individual dose adjustments are required to enable therapy adherence.
Association of the 3′UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity
Authors: Ruiz-Padilla Alan Joel , Morales-Hernandez Gerardo , Ruiz-Noa Yeniley , Alonso-Castro Angel Josabad , Lazo-de-la-Vega-Monroy Maria Luisa , Preciado-Puga Monica del Carmen , Rangel-Salazar Ruben , Ibarra-Reynoso Lorena del Rocio
Published: July 2019

Background

Fibroblast growth factor 21 (FGF21) is considered an important regulator of lipid and glucose metabolism. However, the role of FGF21 in macronutrient intake and metabolic disease, particularly in pediatric population, still needs further clarification. This study aimed to evaluate the association of rs11665896 in the FGF21 gene with metabolic status and macronutrient intake in a cohort of Mexican children with obesity.

Methods

Eighty-four lean children and 113 children with obesity, from 8 to 11 years of age, were recruited. FGF21 rs11665896 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Somatometric evaluations, nutrient intake, glucose, lipids, insulin and FGF21 serum levels were measured in the obesity group.

Results

The T allele of rs11665896 in the FGF21 gene was associated with obesity (odds ratio [OR] = 1.99, 95% confidence interval [CI] = 1.14–3.46; p = 0.0151). Subjects with obesity carrying the TT genotype consumed less lipids and more carbohydrates compared to other genotypes. Circulating FGF21 levels correlated negatively with carbohydrate intake (r = −0.232, p = 0.022) and positively with body weight (r = 0.269, p = 0.007), waist (r = 0.242, p = 0.016) and hip girth (r = 0.204, p = 0.042). FGF21 levels were lower in carriers of at least one T allele.

Conclusions

Genetic variants in FGF21 could influence metabolic status, food preferences and qualitative changes in nutritional behavior in children.
Pediatric stroke as the presenting symptom of new-onset type 1 diabetes mellitus without DKA: case report and literature review
Authors: Bharill Sonum A. , Hunter Janel D. , Walsh Elizabeth T. , Crudo David F. , Constantacos Cathrine
Published: July 2019

Background

Stroke and other neurologic complications are rare in pediatric type 1 diabetes mellitus (T1DM) without severe diabetic ketoacidosis (DKA) or poor glycemic control.

Case presentation

A previously healthy, 10-year-old female presented with acute thalamic stroke, non-acidotic new T1DM diagnosis and negative hypercoagulopathy workup. She received routine insulin therapy and aspirin, and returned to neurologic baseline within a year without stroke recurrence.

Conclusions

The contribution of non-acidotic hyperglycemia to stroke risk is better described in adults. Even though unable to prove causality, this case should at least raise awareness of the possible association of pediatric new-onset diabetes and stroke for optimal outcomes.
National Self-Image as a Justification in Policy Debates: An International Comparison
Authors: Alasuutari Pertti , Vähä-Savo Valtteri , Pi Ferrer Laia
Published: July 2019

In national policymaking speakers commonly refer to models and policies adopted elsewhere as a means to justify a bill. However, empirical analysis of parliamentary talk in eight national parliaments (Argentina, Canada, Chile, Finland, Mexico, Russia, Spain and the USA) reported in this article showed an interesting relationship between two types of justifications: of the eight countries compared, the ones that rank lowest in references to the international community as means to justify or criticize domestic legislation rank highest in the frequency with which national self-image is evoked. Yet these two types of justification exist in the same debates, because the occurrence of both of these discourses correlates with debate length. The variation is due to differences between political cultures: in countries like Argentina and the USA, where national self-image is employed most frequently, speakers have at their disposal stories that bolster beliefs about the country’s uniqueness. In contrast, in the parliaments of Canada and Finland, where references to national self-image are most infrequent, references to the country’s history are rare, and talk about national self-image is entwined with international references.
In vivo electrical impedance measurement in human skin assessment
Authors: Kubisz Leszek , Hojan-Jezierska Dorota , Szewczyk Maria , Majewska Anna , Kawałkiewicz Weronika , Pankowski Edward , Janus Marta , Cwajda-Białasik Justyna , Mościcka Paulina , Jawień Arkadiusz
Published: July 2019

Structural and chemical alterations in living tissue are reflected in electrical impedance changes. However, due to the complexity of skin structure, the relation between electrical parameters and physiological/pathological conditions is difficult to establish. The impedance dispersion reflects the clinical status of the examined skin tissue and, therefore, it is frequently used in a non-invasive evaluation of exposing skin to various factors. The method has been used to assess the effect of the fish collagen on the skin of patients suffering from the leg ulcer. Therefore, from a number of different approaches to skin electrical impedance dispersion, the one considered to be safe was selected and applied. This paper presents a short review of different technical approaches to in vivo electrical impedance measurements, as well as an analysis of the results and the effect of fish collagen locally administered on human skin.
The effect of the withdrawal speed on properties of nickel oxide thin films
Authors: Kayani Zohra Nazir , Aslam Atiqa , Ishaque Rabia , Zahra Syeda Nosheen , Hanif Hifza , Maken Noor-Ul-Ain , Khan Hajra
Published: July 2019

Nickel oxide thin films have been prepared by sol-gel dip-coating technique on glass substrate. It is shown that nickel oxide thin films have poly crystalline nature. Nickel oxide thin films exhibit high transmission (39–85%) in the wavelength range of 400–900 nm, strong absorption between 300 and 400 nm wavelengths and decrease of band gap values are in the range 3.69–3.27 eV with increase of withdrawal speed. High band gap at low withdrawal speed is because of the small average crystallite size, which decreases with increase in withdrawal speed. The SEM micrograph shows cubic crystallites and surface of thin films become dense, smooth and homogeneous with an increase in withdrawal speed. Assessment of nickel oxide deposition conditions provides gateway for effective and cheap solar cells.
TiO2–SiO2 nanocomposite as a highly efficient catalyst for the solvent-free cyclocondensation reaction of isatins, cyclohexanones, and urea
Authors: Janitabar-Darzi Simin , Abdolmohammadi Shahrzad
Published: July 2019

A TiO2–SiO2 nanocomposite catalyzes the one-pot cyclocondensation reaction of 1H-indole-2,3-diones (isatins), 1,3-cyclohexanediones, and urea at T = 70°C under solvent-free conditions with high efficiency. The present method affords the corresponding spiro products in high yields and short reaction time. The unique features of the TiO2–SiO2 nanocomposite are high catalytic activity, ease of preparation, non-toxicity, low loading, and recyclability.
Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACC
Authors: Kar Adwitiya , Zhang Yu , Yacob Betelehem W , Saeed Jordan , Tompkins Kenneth D , Bagby Stacey M , Pitts Todd M , Somerset Hilary , Leong Stephen , Wierman Margaret E , Kiseljak-Vassiliades Katja
Published: July 2019

Adrenocortical carcinoma (ACC) is an aggressive orphan malignancy with less than 35% 5-year survival and 75% recurrence. Surgery remains the primary therapy and mitotane, an adrenolytic, is the only FDA-approved drug with wide-range toxicities and poor tolerability. There are no targeted agents available to date. For the last three decades, H295R cell line and its xenograft were the only available preclinical models. We recently developed two new ACC patient-derived xenograft mouse models and corresponding cell lines (CU-ACC1 and CU-ACC2) to advance research in the field. Here, we have utilized these novel models along with H295R cells to establish the mitotic PDZ-binding kinase (PBK) as a promising therapeutic target. PBK is overexpressed in ACC samples and correlates with poor survival. We show that PBK is regulated by FOXM1 and targeting PBK via shRNA decreased cell proliferation, clonogenicity and anchorage-independent growth in ACC cell lines. PBK silencing inhibited pAkt, pp38MAPK and pHistone H3 altering the cell cycle. Therapeutically, targeting PBK with the small-molecule inhibitor HITOPK032 phenocopied PBK-specific modulation of pAkt and pHistone H3, but also induced apoptosis via activation of JNK. Consistent with in vitro findings, treatment of CU-ACC1 PDXs with HITOPK032 significantly reduced tumor growth by 5-fold (P < 0.01). Treated tumor tissues demonstrated increased rates of apoptosis and JNK activation, with decreased pAkt and Histone H3 phosphorylation, consistent with effects observed in ACC cell lines. Together these studies elucidate the mechanism of PBK in ACC tumorigenesis and establish the potential therapeutic potential of HITOPK032 in ACC patients.
Inclusion of Older Patients with Cancer in Clinical Trials: The SAGE Prospective Multicenter Cohort Survey
Authors: Canouï-Poitrine Florence , Lièvre Astrid , Dayde Florent , Lopez-Trabada-Ataz Daniel , Baumgaertner Isabelle , Dubreuil Olivier , Brunetti Francesco , Coriat Romain , Maley Karin , Pernot Simon , Tournigand Christophe , Hagege Meoin , Aparicio Thomas , Paillaud Elena , Bastuji-Garin Sylvie
Published: July 2019

Background

The primary objective was to evaluate the rates of older patients with colorectal cancer (CRC) who were eligible for a clinical trial, invited to participate, and, ultimately, included. The secondary objective was to assess the reasons for ineligibility, noninvitation, and noninclusion and factors associated.

Materials and Methods

The Sujets AGés dans les Essais Cliniques (SAGE; Older Subjects in Clinical Trials) multicenter prospective cohort was established in seven centers (10 departments of medical oncology, digestive oncology, and digestive surgery) between 2012 and 2016. All patients with CRC aged 65 or older were studied. The endpoints were clinical trial availability, patient's eligibility, invitation, and enrollment in a trial.

Results

We included 577 older patients (mean age ± SD: 75.6 ± 7 years; males: 56%; metastasis: 41%). Thirty-seven trials were ongoing (one trial for older patients). Of the 474 patients with at least one available trial for their cancer stage and site, 127 (27%) were eligible; 84 of these 127 (66%) were invited to participate, and 70 of these 84 (83%) were included. In a multivariate analysis, noninvitation was found to be associated with older age (p = .016): adjusted relative risk (95% confidence interval), 0.14 (0.02–0.60) for ≥80 vs. 65–69; 0.54 (0.18-1.04) for 75–79 vs. 65–69; 0.47 (0.17-0.93) for 70–74 vs. 65–69.

Conclusion

Three-quarters of older patients with CRC were ineligible for a clinical trial. One-third of the eligible patients were not invited to participate in a trial, and 17% of invited patients were not included. Few trials are reserved for older patients. Patients aged 80 or older were significantly less likely to be eligible for a trial and invited to participate. Clinical trial identification number: NCT01754636.

Implications for Practice

The results of this study suggest that barriers to participation of older patients in clinical trials are particularly marked at age 80 years or older. Secondly, the results emphasize the need for trials for older patients. Thirdly, there is also a need for more pragmatic “real-world” trials, rather than solely randomized trials performed in idealized settings with strictly selected patients. Large prospective observational cohorts with a precise follow-up of toxicity, functional decline, and quality of life may constitute one way of generating more data on the risk-benefit ratio for cancer treatments in older patients.
Vertical distribution of shear stress in unsteady open-channel flow
Authors: Tu Haizhou , Graf W. H.
Published: July 2019

The shear stress on horizontal planes and its vertical distribution in unsteady open-channel flow-exemplified by different hydrographs in a gravel-bed flume-are calculated from the time records of the point velocities, using the equation of motion (equation (1)). It is shown that during a flood hydrograph: shear stress near the water surface arrives at its maximum value later than that near the bottom (Fig. 3); at the same water height, the shear stress in the rising branch can be considerably larger than the one in the falling branch (Fig. 4(b)); the vertical shear-stress profiles for the rising branch are concave, implying accelerating flows, and for the falling branch are convex, implying decelerating flows (Fig. 5). These observations are theoretically explained (equation (9) and Fig. 6).
Relationship between water permeability and pore structure of cementitious materials
Authors: Sakai Yuya
Published: July 2019

To understand the relationship between water permeability and the pore structure of cementitious materials, this paper reviews the literature on both water permeability and pore structure and the correlation between them. Although the majority of this data is for cement paste, mortar, concrete and cemented soil are also included. Based on this study, it is established that the determination coefficient between water permeability and the total pore volume is very low. while those between water permeability and the critical threshold and median pore diameters, respectively, are moderate. On the other hand, the threshold pore diameter, derived based on percolation theory, exhibits a very high determination coefficient. The calculated water permeability, using the Katz–Thompson equation, agrees with the reported water permeability quantitatively to a certain degree, but is overestimated.
PEMBERDAYAAN MASYARAKAT DALAM PENGEMBANGAN DESA WISATA DAN IMPLIKASINYA TERHADAP SOSIAL BUDAYA DI DESA SENDANGAGUNG, MINGGIR, SLEMAN
Authors: Widyaningsih Heni
Published: July 2019

ABSTRAKPenelitian ini bertujuan untuk mengetahui pemberdayaan masyarakat dalam pengembangan desa wisata dan implikasinya terhadap sosial budaya di desa Sendangagung, Minggir, Sleman. Penelitian ini menggunakan pendekatan  kualitatif dengan jenis studi deskriptif. Hasil dari penelitian ini yaitu proses pemberdayaan masyarakat di Desa Sendangagung meliputi 3 tahapan, yaitu tahap membentuk iklim masyarakat berkembang, tahap memperkuat potensi dan komunitas, serta tahap pendampingan kelompok. Pengembangan potensi Desa Sendangagung terdiri dari 3 hal yaitu pengembangan potensi sumber daya manusia, potensi budaya dan potensi alam. Implikasi pemberdayaan masyarakat melalui pengembangan desa wisata budaya di Desa Sendangagung terhadap ketahanan sosial budaya wilayah berupa pelestarian terhadap budaya dan adat istiadat setempat, adanya perubahan mata pencaharian masyarakat, dengan adanya desa wisata maka pengelola harus menggali dan mempertahankan nilai-nilai adat serta budaya yang telah dimiliki, menimbulkan rasa bangga bagi penduduk desa untuk tetap tinggal di desanya, penguatan kehidupan beragama dan tetap terjaganya nilai-nilai kekeluargaan sosial masyarakat. Kata Kunci:, Desa Wisata,  Pemberdayaan Masyarakat, Sosial Budaya  EMPOWERMENT OF COMMUNITY IN DEVELOPMENT OF TOURISM VILLAGE AND ITS IMPLICATIONS ON SOCIAL CULTURE IN SENDANGAGUNG VILLAGE, MINGGIR, SLEMAN ABSTRACTThis study aims to determine community empowerment in the development of tourist villages and their implications for socio-culture in the village of Sendangagung, Minggir, Sleman. This study uses a qualitative approach with a type of descriptive study. The results of this study are the process of community empowerment in Sendangagung village which includes 3 stages, namely the stage of forming a developing community climate, the stage of strengthening potential and community, and the group mentoring stage. The potential development of the Sendangagung village consists of three things, namely the development of the potential of human resources, the potential of culture and natural potential. Implications of community empowerment through the development of cultural tourism villages in Sendangagung village towards the socio-cultural resilience of the region in the form of preservation of local culture and customs, changes in people's livelihoods, with the existence of tourism villages, managers must explore and maintain their customary and cultural values , creating a sense of pride for the villagers to remain in their villages, strengthen religious life and maintain the social values of the community. Keywords: Community Empowerment, Socio-Culture, Tourism Village
Detection of Antigens of Cardiotropic Viruses in Atherosclerotic Plaques in Patients with Fatal Myocardial Infarction
Authors: Alekseeva Ya. V. , Rebenkova M. S. , Gombozhapova A. E. , Rogovskaya Yu. V. , Ryabov V. V.
Published: July 2019

Aim. To assess the frequency of detection of cardiotropic virus antigens in coronary artery atherosclerotic plaques in patients with fatal myocardial infarction (MI).

Materials and methods. We examined fragments of coronary plaques of 12 patients with fatal type 1 MI. Immunohistochemistry (IHC) of plaques was performed with the paraffin blocks using antibodies to Herpes simplex virus (HSV)-1, HSV-2, HSV-6, cytomegalovirus (CMV), parvovirus B19, adenovirus, Epstein-Barr virus and enteroviruses.

Results. According to the IHC all patients had virus antigens. The most common virus agents in fragments of coronary plaques were HSV-6 (10 patients) and enteroviruses (5 patients). Antigens of CMV, parvovirus B19, adenovirus, Epstein-Barr virus were not detected in any case.

Conclusions. In this study viral antigens in coronary artery atherosclerotic plaques were found in all victims of fatal MI. There was no difference in the frequency of detection and type of viral agents between plaques in culprit arteries and uncomplicated atherosclerotic plaques.
The Method of Assessment of the Population Risk of Cardiovascular Diseases: Rationale and Examples of Application
Authors: Maximov S. A.
Published: July 2019

Epidemiological studies in cardiology often are confronted with the need of modeling the population dependence of the development of cardiovascular diseases (CVD) on a complex of influencing risk factors (RF). A method for assessment the CVD population risk is proposed, the calculation of which assumes the population group as the unit of analysis, and the prevalence of risk factors in this group as the input data. Calculation of the population risk is build taking into account predictive value of risk factors basing on their contribution to CVD prevalence. The method of calculation of population risk, examples of its application (arterial hypertension in working population, ethnic groups, ischemic heart disease in open and working population), as well as discussion of its strong and weak sides are presented in this review.
Understanding the Selection of Vocabulary Learning Strategies: The Impact of the Language Teaching Approach
Authors: Castellano Risco Irene
Published: July 2019

This paper presents a study on how the selection of vocabulary learning strategies is affected by the kind of instructional programme followed. A total of one hundred thirty-eight secondary-school learners – seventy-two CLIL (Content and Language Integrated Learning) and fifty-six mainstream EFL (English as a Foreign Language) learners – took part in the study. They were asked to respond a vocabulary learning strategies questionnaire. The data were examined looking into how the use of strategies differed when comparing CLIL and EFL learners. Results permitted to develop two clear learner profiles that were compared. These findings will be discussed in relation to their possible implications for vocabulary development.
Designing the Lexical Rules for the Parsing of ASD-STE100 Function Words in ARTEMIS from a Role and Reference Grammar Perspective
Authors: Fumero-Pérez María del Carmen , Díaz-Galán Ana
Published: July 2019

ARTEMIS (Automatically Representing Text Meaning via an Interlingua-based System), is a natural language processing device, whose ultimate aim is to be able to understand natural language fragments and arrive at their syntactic and semantic representation. Linguistically, this parser is founded on two solid linguistic theories: the Lexical Constructional Model and Role and Reference Grammar. Although the rich semantic representations and the multilingual character of Role and Reference Grammar make it suitable for natural language understanding tasks, some changes to the model have proved necessary in order to adapt it to the functioning of the ARTEMIS parser. This paper will deal with one of the major modifications that Role and Reference Grammar had to undergo in this process of adaptation, namely, the substitution of the operator projection for feature-based structures, and how this will influence the description of function words in ARTEMIS, since they are strongly responsible for the encoding of the grammatical information which in Role and Reference Grammar is included in the operators. Currently, ARTEMIS is being implemented for the controlled natural language ASD-STE100, the Aerospace and Defence Industries Association of Europe Simplified Technical English, which is an international specification for the preparation of technical documentation in a controlled language. This controlled language is used in the belief that its simplified nature makes it a good corpus to carry out a preliminary testing of the adequacy of the parser. In this line, the aim of this work is to create a catalogue of function words in ARTEMIS for ASD-STE100, and to design the lexical rules necessary to parse the simple sentence and the referential phrase in this controlled language.
Educational attainment of Eastern European pupils in primary schools in England: Implications for policy and practice
Authors: Demie Feyisa
Published: July 2019

The aim of this article is to explore the attainment of Eastern European children in primary schools in England. The research draws on detailed National Pupil Database and school census data for 586,181 pupils who completed Key Stage 2 in England in 2016. Two methodological approaches
were used to analyse the data. First, the performance of all pupils was analysed by ethnic and language background to illustrate patterns of attainment for each group. Second, attainment data were further analysed by social background factors to explore the main factors influencing performance
in schools and the reasons for underachievement. The main findings from the study confirm that a number of Eastern European pupils have low attainment, and their performance in English schools has been masked by government statistics that fail to distinguish between 'White Other' ethnic groups.
The empirical data suggest that speakers of Czech, Slovak, Hungarian, Polish, Romanian, Latvian, Lithuanian and Bulgarian are particularly underachieving, and that the difference between their educational performance and others is larger than for any other main groups. There is also a wide
variation in performance between regions in England, with large attainment gaps between Eastern European and White British children. Some of the main reasons for underachievement identified from the study are the lack of fluency in English, economic deprivation, a disrupted or non-existent
prior education and parental lack of understanding of the British education system. Overall, this research confirms that the underachievement of Eastern European children remains a cause for concern and is obviously an issue that policymakers and schools need to address. Implications for policy
and practice are discussed in the final section.
Surveying the infrastructures required for implementation of e-learning in smart schools in Bushehr Province
Authors: Behroozi Mohammad , Ajam Shahnaz Olyan
Published: July 2019

Although today the evaluation is concerned as one of the most significant processes of management in all of organizations, this issue has been much more paid attention in universities and higher education institutes for training expert human resources and producing knowledge and technology. Also, the evaluation of teaching quality is one of the major criterion for accreditation any university and efficacy of that university's academic faculties as well. This paper is to survey the attitude towards the evaluation of teaching quality done based on the surveying and comparing students' and professors' views among three groups of business management, industrial management, and accounting departments in Persian Gulf University in Bushehr. This is a descriptive-surveying study, so a research-structured questionnaire was applied to measure and evaluate the teaching quality. Statistical population consisted of 1280 students studying in Persian Gulf University among which 276 persons were randomly selected based on stratification sampling method and 28 faculty members. Content analysis was used for validity and Chronbach's Alpha was also used for reliability(Î±=0.92). Findings, based on T-test, ANOVA, Regression Analysis, Factor Analysis, and Pearson's Correlation Coefficient, showed that the following indexes would be known as the effective factors on the attitude and evaluation of teaching process quality respectively: quality evaluation, satisfaction of evaluation results, keeping educational regulations, teaching style, applying education technology, student and professor exchange, awareness of evaluation goals, and entire satisfaction from research activities.

Key words: Smart school, e-learning, software infrastructures.
Social learning as a Europeanisation tool: Case study Macedonia
Authors: Pollozhani Azis , Hamiti Mentor
Published: July 2019

Education is the main pillar of society for building values and the well-being of its citizens. Its transformational power is imperative, making it a crucial tool in state policies for efficient and timely transformation of a society ready to face new challenges. The Republic of Macedonia faced numerous challenges while modernising and redesigning its educational programmes, to empower its future generations with skills and knowledge in accordance with the labour marketâ€™s needs, in the global technological and scientific environment and in promoting European values as new paradigms in the so-called Europeanisation of society. The Macedonian education system experienced some disputable changes: reforms were focused on the quantitative performance of students, and not on the quality or impact of education in building a futuristic society. The republic worked towards the adaptation of the inherited education system to new challenges in a plural democratic society, market economy and an increasingly globalised world.

Keywords: Education, social learning, social cohesion, Europeanisation, Republic of Macedonia.
Investigation of the students’ level of motivation and creativity studying at School of Physical Education and Sports
Authors: Tekin Murat , Akbay Busra , Din Yavuz Selim
Published: July 2019

The purpose of this study is to investigate the s tudents ’ level of motivation and creativity studying at School of Physical Education and Sports . The research group comprised 93 female and 107 male (x age = 21.4607  1.8792), 200 in total, studying a t the Physical Education and Sports School of Karamanoglu Mehmet Bey University. ‘A Scale of Achievement Focused Moti va tion’ and ‘Adapta tion-I nnova ti on Inventory’ were applied to the students who parti cipa ted in the resea rch. Inthe anal ysis and assessment of the data , Kol mogorov–Smi rnov test, Kruskal–Wallis H test, Mann–Whi tney U tes t and Correla tion tes t were used and signi fi cance was taken as P < 0.05. As a resul t of the study, there is no si gnifi cant difference between the levels of crea ti vi ty and sub-dimensions of moti va tion (internal and external action, setting higher goals and self conscious) accordi ng to gender, parent’s educa tional background and doing sports acti vely which are the variables of participating students.
Keywords: Creativity, motivation, student.
Formation and development of vocational mobility of the future teacher of Physical Education in educational space of university
Authors: Fugelova Tatiana Anatolievna
Published: July 2019

The article is based on the idea of conjugation between social and personal factors in the preparation of a teacher of Physical Education (PE). It creates the conditions for building a harmonious relationship with the surrounding world, finding one's place in society, vocational orientation, formation of readiness for adaptability and mobility in the future vocational activity. The conditions, ensuring the formation and development of vocational mobility of the future teacher of PE in the socio-cultural educational space of high school, are dialogization, taking part of the future experts in project activities at various levels.  We have considered the process of formation and development of vocational mobility of the future expert in the social and cultural educational space of high school within the framework of the continuing education system. The concept of continuing education involves the inclusion of dialogue relationship, which contributes to the formation and development of vocational mobility of the future teacher of PE at all levels: knowledge, skills, creativity, experience in value and emotional orientation. The transition from one level of formation of vocational mobility to the other one in the socio-cultural educational space of high school is provided by the realization of the complex of strategic conditions and pedagogical tactics (pedagogical support, educational accompaniment, enhance social and vocational values), which contribute to the development of the readiness of the future teachers of PE to changes, innovations in the process of vocational activity.
Keywords:  vocational mobility, educational space, continuing education, strategies and tactics of vocational mobility.
The reflection of organisational culture on technology usage in secondary education classes
Authors: Ozberk Ozge , Ozberk Kenan
Published: July 2019

The purpose of this research is to find out â€œThe reflection of organizational culture on technology usage in secondary education classesâ€. This is a case study which is a qualitative method. 10 teachers were chosen as participants via chain sampling. The data were collected by means of open-ended questions asked at semi-structured interviews. The researchers recorded the intervieweesâ€™ responses by taking notes. The data was processed via content and thematic analyses. Tables were used to present the data. The findings of the study indicate that the school leaders are not able to find efficient solutions to problems about in-class technology usage. It is also determined that virus programs on computers are not up to date. Teachers do not prefer using technology in their classes since they are anxious about falling behind the annual plan and the classes are over-crowded. Another noteworthy finding is that even though some teachers use technology for educational purposes, help each other and share their materials, there are some teachers who do not act responsibly concerning the usage and protection of the devices.

Keywords: Organisational culture, technology, school director