bluuebunny/crossref_metadata_2025 huggingface dataset:
MANAJEMEN PENDIDIKAN ISLAM DALAM MENJAGA KUALITAS PEMBELAJARAN DI TENGAH PENDEMI COVID-19
Authors: Wahyudi Basri Ahmad
Published: November 2021

This article wants to discuss how the management of Islamic education in maintaining the quality of learning in the midst of the Covid-19 pandemic. Islamic education during a pandemic must have the right management because Islamic education is not only concerned with intellectual issues but also about spiritual issues. The purpose of Islamic education is a starting ethic, so automatically the management of Islamic education must be correct. During the pandemic, the management carried out by the Ministry of Religion and its staff launched a planning, management and supervision by means of online learning. Implementers of each school along with supervision and parents and peers are the most core supervisors in Islamic education. By using qualitative methods based on previous research and several books as primary and secondary sources, it is hoped that it can make a big contribution to Islamic education and scientifically there is an image of a new file taste for future scholarship.
Kompetensi pustakawan di perpustakaan adrasah aliyah dan tsanawiyah negeri se-kota Banjarmasin Kalimantan Selatan
Authors: Rahmawati Laila , Juairiah Juairiah , Wahdah Siti
Published: November 2021

Introduction. This study aims to determine how far the competence of school/madrasah librarians in the city of Banjarmasin.Data Collection Methods. This type of qualitative research uses a qualitative approach. The research subjects were school librarians in the city of Banjarmasin (MAN 2 Model, MTsN Pemurus Dalam, MTsN 1 Pekauman, MTsN 3 Mulawarman and MAN 3 Mulawarman). The object of research is the competence of school librarians. Data collection techniques using the method of observation, interviews and documentation.Data Analysis. Data analysis techniques using data reduction, data presentation, triangulation, drawing conclusions.Results and Discussion. Thoose are: 1) the managerial competence of librarians still focuses on administrative evaluation, 2) the information management competence of librarians has not been fully able to meet the expectations of information management competence, 3) the educational competence must improve competence literacy, 4) the personality competence has not have professional awareness, 5) the social competence of librarians is still not paying attention to the development of personal character in the pattern of relationships with users, 6) the competence of professional development of librarians has not been able to describe adequate competencies, especially in the form of scientific works or scientific publications.Conclusion. Thoose are 3 main factors that can improve the competence of librarians, namely individual factors, school factors and the desire to attend education and seminars.
Program pengembangan minat baca di Perpustakaan Kota Banjar Patroman
Authors: Majid Anwar Abdul
Published: November 2021

Introduction. This study focuses on the management of the Reading and Literacy Tourism program in the aspect of POAC (Planning, Organizing, Actuating, Controlling). The development of reading interest is an effort made to increase people's reading interest and habits, with the existence of a reading interest development program it can encourage an increase in people's reading interest. One of the roles to develop people's reading interest is the library. The City Library of Banjar Patroman has one program in an effort to develop interest in reading, especially for early childhood in PAUD, TK and RA in Banjar Patroman City. This activity is called Reading and Literacy Tourism which is carried out by traveling while reading books.Data Collection Methods. The research method used is descriptive qualitative method. Research data obtained through interviews, observation and document analysis.Data Analysis. The analysis uses several objects in the form of behavior, perception, motivation, action, and others holistically, and by means of description in the form of words and language, in a special natural context and by utilizing various natural methods.Results dan Discussion. The City Library of Banjar Patroman uses the planning concept that has been regulated in the Terms of Reference (KAK), then organizing there are 15 committee members who divided into 6 divisions, the implementation is carried out 2 times a week or 24 times a year and the implementation of this  activity is carried out during the Covid-19 pandemic with a limitation of 20 participants consisting of accompanying teachers and participants, supervision of this activity uses direct supervision, indirect supervision, internal control and external supervision.Conclusion. The results of this study indicate that the Banjar Patroman City Library in developing early childhood reading interest through Reading and Literacy Tourism activities in managing its activities using the POAC aspect.
Improving Students' Physics Learning Outcomes Through Implementation of Peer Teaching Method
Authors: Nuriyani Yeni , Winarso Widodo
Published: November 2021

Classroom action research using peer teaching methods to improve learning outcomes in physics subject circular motion. This study's subjects were students of class X MIPA 3 SMA Negeri 4 Cirebon, Cirebon City, West Java Province, totaling 32 students. The data collection technique is done by test and observation. The research process was carried out in two cycles, each cycle consisting of four stages, namely: (1) action planning, (2) action implementation, (3) observation and interpretation, and (4) analysis and reflection. Based on the research that has been done, it can be concluded that there is an increase in learning outcomes in physics subject of student circular motion through the use of the Peer Teaching method. Pre-cycle data with a class average of 60.94 with a percentage of 28.13% complete learning or 9 students out of 32 students. The first cycle increased to 72.19% or 17 students completed with an average student grade of 53.13%, but this score had not yet reached the KKM that had been agreed upon. The second cycle increased to 81.25%, or 26 students completed with an average student score of 84.84. Thus, the peer teaching method's application can improve learning outcomes in the Physics subject of circular motion so that it is feasible to be applied in SMA Negeri 4 Cirebon
CAPACIDADES DINÂMICAS E CAPACIDADE DE INOVAÇÃO EM SERVIÇOS DE SAÚDE
Authors: Froehlich Cristiane , Nodari Cristine Hermann
Published: November 2021

The work aims at understanding the capacity of innovation in health services in light of the microfoundations of dynamic capabilities. The study adopted the framework by Teece (2007), which presents three dynamic capabilities: (a) the ability to identify the environment context (sensing); (b) the ability to seize opportunities (seizing); and (c) the ability to manage threats and transformations (reconfiguring). For this research, a qualitative case study with exploratory and descriptive characteristics was carried out in a private hospital located in the city of Porto Alegre, Brazil. The main results show that the understanding routines and processes through microfuses facilitates the visualisation and understanding of the dynamic sensing, seizing and reconfiguring capabilities.
INOVAÇÃO SOCIAL APLICADA À ÁREA DE GESTÃO: UMA ANÁLISE CONCEITUAL
Authors: Correia Suzanne Érica Nóbrega , Machado André Gustavo Carvalho
Published: November 2021

O objetivo deste estudo é analisar as abordagens de inovação social aplicadas aos estudos da área de gestão. Em termos metodológicos, foram analisados 151 artigos publicados nos últimos vinte anos na área de gestão, selecionados na Web of Science. A análise qualitativa foi ancorada com o software Iramuteq. Os resultados indicam três categorias: a) Inovação Social Corporativa, que estende a lente da inovação social para além das empresas sociais; b) Constructos da Inovação Social, que apresenta o foco conceitual à luz dos autores investigados; c) Estudos da Inovação Social, que explica como as metodologias de investigação têm sido aplicadas.
APRENDIZAGEM INTERORGANIZACIONAL E MARKETING DE RELACIONAMENTO: UM ESTUDO EXPLORATÓRIO
Authors: Larentis Fabiano , Mello Claudio Baltazar Corrêa de , Antonello Claudia Simone
Published: November 2021

Este trabalho tem como objetivo analisar os processos de aprendizagem advindos dos relacionamentos interorganizacionais nas práticas do marketing de relacionamento entre fornecedores e clientes, através de um estudo qualitativo básico junto a empresas, com entrevistas em profundidade. Identificou-se a preponderância de processos informais de aprendizagem interorganizacional, a partir de experiências, trocas e mudanças de visões de mundo, tendo em vista as situações de aprendizagem, bem como o aprender a confiar, a se comprometer e a cooperar. Os processos formais de aprendizagem, por outro lado, contribuíram para o desenvolvimento de processos informais, e vice-versa.
ANÁLISE DE DIMENSÕES DE CAPACIDADE ABSORTIVAS EM PARQUES TECNOLÓGICOS
Authors: Eckert Daniela Carolina , Maldaner Luis Felipe , Fiorin Flávia Siqueira
Published: November 2021

The objective of this research is to analyze how the dimensions of the absorptive capacity are evidenced, from the processes of environmental scanning, as it is important to understand the mechanisms that are determinant for these evolutions. In order to validate the interview script, a pilot test was provided with the manager of Barcelona's La Salle Technova. After that, interviews with managers of five Tech Parks in Brazil, one in Spain, and one in South Africa were carried out. The results show a positive influence of the surveyed dimensions on the absorptive capacity of the technology parks.
FUSÕES E AQUISIÇÕES CROSS-BORDER: CARACTERÍSTICAS DE MERCADO E DESEMPENHO ECONÔMICO-FINANCEIRO
Authors: Martins Rayana Kelly Brasileiro , Callado Aldo Leonardo Cunha
Published: November 2021

A presente pesquisa tem como objetivo analisar o efeito que as características de mercado provocam no desempenho econômico-financeiro de empresas envolvidas em processos de fusões e aquisições do tipo cross-border. Para seu desenvolvimento adotou-se o modelo de regressão com dados em painel por efeitos fixos e aleatórios. Apesar de alguns trabalhos da literatura indicarem que o desenvolvimento de mercado impacta na criação de valor das empresas adquirentes, os resultados obtidos nesta pesquisa refutam a hipótese de que em mercados desenvolvidos, os processos de F&As cross-border estão positivamente associados ao desempenho obtido após concretização da fusão.
Persiflages van “Jiskefet” als lesondersteuning
Authors: Hamers Bas
Published: November 2021

The satirical television series Jiskefet ran from 1990 to 2005 at the VPRO channel. While the popular satirical television series Kooten & De Bie focused more on political parody, Jiskefet was more absurdist and mainly made parodies of certain subcultures. In this article, I want to look at how these timeless parodies can be used as course materials. Not only is Jiskefet itself part of Dutch culture, but the parodies also magnify typical Dutch cultural elements. Examples include student associations, the culture of voluntary work, nursing homes that often appear in the news, and the office culture with the inevitable lunch box and office humor. Furthermore, the parodies constitute interesting linguistic material in the form of neologisms, which have enriched the Dutch language and will also be discussed here. Finally, the fact that stereotypes and prejudices are used in parodies offers the possibility of discussing the subject with students.
De postkoloniale geschiedenis in polyfonie
Authors: Kuznik Judyta
Published: November 2021

This article focuses on the book Het andere postkoloniale oog, edited by Michiel van Kempen and published in 2020 by the publishing house Verloren. This book had the goal to present never before mentioned aspects of the colonial history of the Netherlands and its influence on cultural practices of the colonised cultures within the last four centuries. Because of the numerous contributions amassed there, the article discusses in depth only a few. These contributions distinguished themselves either through an original academic approach to the topic or the positioning with regard to postcolonial theories usage. The first part of this book involves the need for the re-evaluation of the Dutch colonial history in many parts of the world, to name Suriname as an example. This re-evaluation is highly relevant, as is comes in a time when recent social movements push the mostly unknown parts of the Dutch colonial history into the spotlight. In the second part, this is followed by an attempt to answer the question whether postcolonial theories are essential for the writing bound to the colonial history of the Dutch. As is shown by some contributions, postcolonial theories can stimulate new discussions, especially in cases which do not fit the existing theoretical schemes. And yet, it seems that they are not crucial in discussions about the influence between colonised cultures, though their use might prove fruitful. The article closes with an evaluation of the analysed texts.
Tolken in de zorg: hoe wordt er met anderstalige patiënten gecommuniceerd?
Authors: Knap-Dlouhá Pavlína
Published: November 2021

This article analyzes structures within which interpreters are deployed in the healthcare sector in the Netherlands and the Czech Republic. It pays particular attention to the status, conditions, and guidelines that guarantee the provision of interpreting services. The first part also explains some important concepts that are closely related to healthcare interpreting, including language brokering and natural interpreting.

Despite the fact that funding for interpreting services was stopped by the government (2012), it is a developed field in the Netherlands. As a reaction to the abolition, there was a wave of protests; many parties believe that this has compromised one of the human rights (the right to access to care). In the Czech Republic, a new law was introduced (2011), the Health Services and Conditions of Provision Act, which guarantees patients the right to communication that is understandable to the patient. Since then, certain facilities were introduced that should make communication with non-native speaking patients effective. Nevertheless, more experience and knowledge should be brought in to be able to speak of a good organizational structure and quality.
An emergency flipped classroom intervention in an L2 Dutch course: An action research study
Authors: Buczak Mikołaj
Published: November 2021

The flipped classroom has been gaining increasing popularity over the last decade, especially in the university context. This pedagogical approach not only contributes to students’ engagement and motivation, but also enables a more flexible management of instructional time in class, which makes it a promising option for emergency situations. In October 2020, a ‘Women’s Strike’ took place in Poland, influencing the teaching schedule in numerous higher education institutions. Since these circumstances caused a problem with managing the course and making it possible for the students to catch up with the new material, an action research investigation was undertaken to explore the applicability of the flipped classroom in an emergency situation. Hence, this article describes the evaluation of a flipped classroom emergency intervention with one group of first-year students of Dutch Studies at Adam Mickiewicz University in Poznań.
Solastalgia and Hope
Authors: Winkler Kathrin , Carroll Seforosa
Published: November 2021

This paper draws attention to the social as well as global consequences, but also to the profound emo­tional impact of the ecological crises from a theological perspective. The phenomenon of solastalgia, as well as the loss of holistic thinking, manifests itself as emotional or existential distress caused by environmental changes, re­sulting in the loosing of home, identity, and culture. In order to provide a response to these urgent theological as well as religious education challenges, this article makes a twofold attempt: On the one hand, it deconstructs the entanglements of Christian missionary societies in European colonial structures of domination that helped legiti­mize the exploitation of natural resources. This includes the understanding that in the name of Christianity, the suppression of indigenous forms of knowledge and cognition, which contain a treasure of concern for nature and forms of sustainable living, was legitimized. On the other hand, the engagement with these historical lines of devel­opment, however, opens up the opportunity to re-engage indigenous narratives of hope in religious education processes and to make their alternative world relations constructive, which is fed by a dialogue with indigenous episte­mology and spirituality. The aim of this paper is to find out what new insights emerge from this dialogue of contexts between the Pacific and Europe and what new horizons they can offer for religious education.
Danner, Sonja (2020). Niemals Nummer – Immer Mensch. Erinnerungslernen im Religionsunterricht (Evangelische Hochschulschriften Freiburg Band 9). Göttingen: Vandenhoeck Ruprecht. ISBN 978-3-8471-1139-9. 331 Seiten.
Authors: Köster Norbert
Published: November 2021

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THE DIFFERENCE OF MUSCULOSKELETAL DISORDERS BEFORE AND AFTER WORKPLACE STRETCHING EXERCISE
Authors: Harahap Mitha Aulia , Situngkir Decy , Irfandi Ahmad , Ayu Ira Marti , Muda Cut Alia Keumala
Published: November 2021

Background: Workers who undertake occupations that require bending, climbing, crawling, reaching, twisting, excessive activity, or repeated movements may suffer from musculoskeletal disorders (MSDs). MSDs can be prevented by doing Workplace Stretching Exercise (WSE) which is useful for minimizing the risk of musculoskeletal injury, fatigue reduction, muscle balance, and posture improvement, and muscle coordination improvement. Purpose: To analyze the difference before and after giving WSE to the reduction of MSDs complaints. Method: This research takes a quantitative approach, utilizing a quasi-experimental design in one group before and after WSE administration. Total sampling is used for sampling. The respondents of this study were 34 workers in the production division of PT Crown Pratama in 2021. The T-paired test was utilized as a statistical test in this study. Result: The results of the univariate test mean MSDs complaints before and after WSE administration were 42.97 and 36.29. Conclusion: The bivariate test revealed differences in complaints of Musculoskeletal Disorders (MSDs) before and after workplace stretching exercise.
EFFECT OF DAILY TRIP SYSTEM ON PT. X CONTRACTOR WORKER FATIGUE AT OFFSHORE SITE
Authors: Nuraini Desi , Ramdhan Doni Hikmat
Published: November 2021

Background: PT. X implements a daily trip method that takes ±1,5 hours to arrive at the offshore platforms. Travel time that’s too long can cause fatigue. Purpose: Analyzing the effect of a daily trip system on PT. X contractor worker fatigue at offshore site. Method: This research was conducted at one of PT. X’s offshore Gresik Sites in June 2021 used Fatigue Assessment Scale (FAS) questionnaire with observational analytics method and cross-sectional study design. Research samples were taken from the population of 153 construction workers PT. X at offshore site. The data obtained were analyzed using quantitative approach, data analysis used univariate analysis and bivariate analysis, chi-square statistical test with significance value or confidence interval was 95% and error interval was 5%  (CI = 95% and α = 0.05). Result: PT. X Contractor workers at the offshore site had 85 workers (55.56%) that get fatigue. Statistical analysis test showed there was no significant relationship between a daily trip system with fatigue on PT. X Contractor workers at the offshore site (p-value = 0.140). Factors that affect fatigue on PT. X Contractor workers at the offshore site were age, body mass index, and workload (p-value successive were 0.047, 0.014, and 0.001). Conclusion: A daily trip system has no effect with fatigue on PT. X contractor worker at the offshore site, recommended for the contractor to improve the BMI and manage the workload so that its more evenly distributed.
Bimbingan Teknis Pembuatan Nata de piel batatas dari Kulit Ubi Jalar (Ipomoea batatas)
Authors: Amintarti Sri , Ajizah Aulia
Published: November 2021

Kulit ubi jalar biasanya hanya dibuang sebagai limbah ke lingkungan, atau kadang dijadikan sebagai makanan ternak. Kulit ubi jalar sebenarnya masih menyisakan bahan-bahan yang dapat dijadikan medium biakan bakteri  Acetobacter xylinum untuk menghasilkan nata. Akan tetapi informasi dari sekolah yang disurvey umumnya belum memiliki pengetahuan langkah-langkah untuk memanfaatkan kulit ubi jalar tersebut dan keterbatasan alat serta bahannya. Telah dilakukan kegiatan Bimbingan teknis cara pembuatan nata yang berbahan dasar kulit ubi jalar kepada guru-guru biologi dan siswa-siswi SMA/sederajat se-kabupaten Tanah Laut dan sekitarnya. Proses pembuatan nata mengacu pada teknik dasar pembuatan nata oleh (Saragih, 2004). Metode kegiatan bimbingan teknis dengan cara: 1) pemaparan materi tentang nata dan cara pembuatan nata; 2) Demonstrasi secara virtual pembuatan nata de piel batatas melalui tayangan video; Kegiatan diikuti oleh 68 peserta yang meliputi guru dan siswa dari 5 SMA Negeri dan 1 MAN serta dari Politeknik yang ada di Kabupaten Tanah Laut. Hasil bimbingan menunjukkan bahwa peserta memahami cara membuat nata de piel batatas yang berasal dari kulit ubi jalar. Berdasarkan jawaban angket yang diberikan setelah bimbingan, sebanyak 74,2% peserta menyatakan memahami cara membuat nata de piel batatas yang berasal dari kulit ubi jalar dan sangat setuju dengan kegiatan ini. Peserta memberikan respon yang positif dan 71,2% berminat untuk mencoba membuatnya. Sweet potato skin is usually only dumped as waste into the environment or sometimes used as fodder. Sweet potato skin still leaves ingredients that can be used to breed bacteria Acetobacter xylinum to produce Nata. However, in school do not know measures to use the sweet potato skin and the limitations of tools and materials. Technical guidance on how to make sweet potato skin-based Nata has been conducted to biology teachers and high school students/equivalents in Tanah Laut and surrounding districts. Making Nata refers to the basic techniques of making Nata by (Saragih, 2004). Methods of technical guidance activities through: 1) exposure of material about Nata and how to make nata; 2) Virtual demonstration of the making of Nata de piel batatas through video viewing; The activity was attended by 68 participants including teachers and students from 5 public high schools and 1 MAN as well as from polytechnics in Tanah Laut Regency. Based on the evaluation after guidance, 74.2% of participants stated that they understood how to make Nata de piel batatas from sweet potato skins and strongly agreed with this activity. Participants gave a positive response, and 71.2% were interested in trying to make it.
Detection of Klebsiella pneumoniae DNA by PCR-Based CRISPR-lbCas12a System
Authors: Wang Shang , Tang Ying , Wei Jiehong , Wang Shan , Peng Guoyu , Li Yuqing , Wu Song
Published: November 2021

Klebsiella pneumonia (K. pneumoniae) is a Gram-negative bacterium that causes nosocomial infections in the lung, bloodstream, and urinary tract. Therefore, detecting K. pneumoniae in early time is important in preventing severe infections. However, clinical detection of K. pneumoniae requires a long time of agar plate culture. Nucleic acid detection like qPCR is precise but requires expensive equipment. Recent research reveals that collateral cleavage activity of CRISPR-LbCas12a has been applied in nucleic acid detection. In this study, PCR combined with CRISPR-LbCas12a targeting the K. pneumoniae system was established. This system showed excellent detection specificity and sensitivity in both bench work and clinical samples. Due to its advantages, its application can meet different detection requirements in health centers where qPCR is not accessible.
Robotic-Assisted Pelvic Reconstruction After Metastatic Renal Cell Carcinoma Resection
Authors: Ameri Bijan Joseph , O’Keefe Shawn , Lima Diego , Higuera-Rueda Carlos , Manrique Jorge
Published: November 2021

Case:

A 76-year-old man presented with metastatic renal cell carcinoma (RCC) in the right acetabulum with pelvic compromise. The patient had right hip pain and difficulty with ambulation, as such he elected to undergo tumor resection with subsequent reconstruction of pelvic defect. Given the size and location of the anticipated pelvic defect, robotic-assisted hip arthroplasty was used to execute prosthetic component placement and anatomic pelvic reconstruction.

Conclusion:

Advances in technology, such as robotics and 3D navigation, have application in orthopaedic oncology surgery, especially for reconstructions after pelvic resections. The goal of this case report is to describe the utility of this technology in a case of metastatic RCC.
Bilateral Toe Walking as Presentation of Unilateral Dysplasia Epiphysealis Hemimelica of the Ankle
Authors: Zhang Bo , Margalit Adam , Lee R. Jay , Shannon Claire E.
Published: November 2021

Case:

We describe a case of dysplasia epiphysealis hemimelica (DEH) of the anterior tibiotalar joint that presented as toe walking in a 6-year-old boy. Radiographs and magnetic resonance images showed substantial exostosis at the anterior ankle that blocked dorsiflexion. He underwent surgical excision and casting for equinus, restoring ankle range of motion and gait.

Conclusion:

Although DEH is benign, it can cause major deficits and permanent damage to a joint when neglected. Recognition of subtle presentations of DEH, such as toe walking, is crucial. Early treatment can restore joint motion and prevent deformity and arthritis.
Total Femoral Replacement for Complicated Echinococcus Infection
Authors: Lal Divakar N. , Roza Gustavo de la , Damron Timothy A.
Published: November 2021

Case:

Osseous hydatidosis caused by Echinococcus is rare, especially in long bones. To the best of our knowledge, this is the third femoral hydatidosis case with successful osseous eradication through total femoral resection and total femoral megaprosthesis. Unlike the previous 2 cases, we uniquely illustrate recurrent soft-tissue hydatidosis episodes requiring additional hydatid resections for local control with no evidence of disease at final 16-year follow-up, the longest follow-up period of the 3 reported cases.

Conclusion:

Despite radical bone resection for osseous hydatidosis eradication, additional complex surgical interventions may be needed to locally control soft-tissue disease.
Study on the Dynamic Mechanical Properties of Metamorphic Limestone under Impact Loading
Authors: Zhang Zhiyu , Qian Qingyun , Wang Hao , Huang Yonghui , Wang Jianguo , Liu Haoshan
Published: November 2021

To study the dynamic damage and fracture of metamorphic limestone under explosive load and the stability of the surrounding rock, the stress-strain curve, fracture morphology, and energy dissipation characteristics of metamorphic limestone in the Dahongshan mining area under different strain rates were studied by the Hopkinson pressure bar (SHPB), stress wave analysis, and fractal theory. The experimental results show that the crushing form and degree are significantly affected by the loading strain rate. There are several typical failure modes. When the strain rate is 17.56 s−1, there is no obvious failure except corner cracks. When the strain rate is between 26.92 s−1 and 56.18 s−1, the failure mode of the specimen is axial splitting failure, and when the strain rate is 67.34 s−1, splitting and shearing failure occur. With the increase of the strain rate, the growth rate of the dynamic compressive strength slows down. Compared with static compressive strength, the strength factor increases from 1.15 to 4.19. Also, the fractal dimension shows a gentle increase. When Df is in the range of 1.82~2.24, there is a sudden change in fragmentation when the strain rate is in the range of 34.70 s−1~56.18 s−1. Energy dissipation density increases logarithmically with the strain rate. The results reveal the dynamic breaking and energy consumption laws of metamorphic limestone under impact loads with different strain rates and could provide some reference value for the safe and efficient construction in the Dahongshan mining area and similar engineering projects.
Expression of Sortilin in Pancreatic Carcinoma and Influence of Pancreatic Cancer Cells by Sortilin siRNA Knockdown
Authors: Xu Di , Yu Fan , Liu Shangqing , Rong Cai
Published: November 2021

BackgroundCurrently, there are few effective therapeutic options for pancreatic cancer patients. Sortilin is a member of vps10p receptor family，reported in many types of cancers. However, the underlying mechanism and prognostic value of sortilin in pancreatic cancer are still unclear. ObjectiveUnderstand the expression of sortilin in pancreatic cancer, and analyze its mechanism that affects the occurrence and development of pancreatic cancer. MethodsA tissue microarray of 115 pancreatic cancer metastases was analyzed by immunohistochemistry. All data were analyzed by univariate analysis and multivariate analysis. Multivariate logistic regression analysis and the area under the receiver operating characteristic (ROC) curve were used to analyze the ability of sortilin in predicting pancreatic cancer. Next, survival analysis was performed to compare the survival time between high-risk and low-risk patients to validate the prognosis prediction efficacy of sortilin. The effects of sortilin on the invasion，metastasis and proliferation of pancreatic cancer cells were investigated both in vitro. investigate the anti-cancer effect of soritlin on human pancreatic cancer Capna1 and Bxpc3 cells, and its possible molecular mechanism. ResultsDifferential expression analysis of 115 tissue microarrays showed sortilin expression was up‐regulated in pancreatic cancer tissues,and it mainly comes from the nucleus. Sortilin expression in nucleus(SEIN) was only negatively correlated with N stage, Binary logistic regression model showed that SEIN is a good diagnostic marker for predicting pancreatic cancer and the accuracy of prediction is as high as 79.1 %. ROC curve analysis demonstrated a statistically significant diagnostic value of SEIN,and the diagnostic accuracy was 86.3%, The Youden Index was calculated to evaluate the diagnostic power, The cut-off value for SEIN in pancreatic cancer diagnosis was 0.85, with a sensitivity of 90.9% and a specificity of 68.3%. Univariate analysis showed that M stage(P=0.022), histological grade(P=0.021), clinic stage(P=0.030)and SEIN(P=0.039) were correlated with prognosis of pancreatic cancer patients, Multivariate regression analysis showed that M stage(P=0.036)and ESIN(P=0.004) were independent factors.The proliferation, invasion and migration of pancreatic cancer cells were inhibited in vitro by sortilin siRNA knockdown.it may have something to do with soritlin/P53/NFκB regulated the the proliferation function and sortilin/MMP9 regulated the invasion-promotion of pancreatic cancer cells. Conclusions﻿These fndings demonstrated that the low expression of SEIN indicates better prognosis in pancreatic cancer and supplemented the effect mechanism of sortilin on pancreatic cancer cells. SEIN expression may serve as a potential diagnostic indicator of pancreatic cancer.
Incidence And Risk Factor Analysis For Swelling After Apical Microsurgery
Authors: Bi Cheng , Xia Siqi , Zhu Yuchi , Lian Xinzhu , Hu Lijun , Rao Chenxing , Jin Haibin , Shang Xiaodan , Jin Feifan , Li Jingyu , Zheng Pei , Wang Shuhua
Published: November 2021

The aim of this prospective observational cohort study is to evaluate developing periapical swelling after apical microsurgery and determine potential risk factors. Ninety-eight apical microsurgery patients were selected for this study. Before surgery, bone shadow volume and density of pathological tissue were measured by CBCT. The other variables (age, gender, operative teeth number, fistula, preoperative swelling, drug use and pre-surgery root canal treatments) were assessed during examination. Swelling degree was confirmed by questionnaires for patients on the 1st, 7th, 14th, and 21st days respectively after surgery. Statistical analyses were performed to identify predictors for swelling. Majority of patients reported moderate (45.9%) or severe (34.7%) swelling on day 1, and moderate (44.9%) or mild (45.9%) on day 7. 99% patients had no or mild swelling on day 14. The average swelling level peaked on day 1 postoperatively and gradually decreased. Of statistical significance, age, bone shadow volume and density of pathological tissue acted as predictors of swelling(P<0.05). However, there was no significant difference in gender, tooth number, fistula, preoperative swelling, drug use, or pre-surgery root canal treatments (P > 0.05). We conclude that younger patients with larger shadow volume and density were significantly more likely to develop swelling after apical microsurgery.
Distinct Expression Pattern and Prognostic Values of E2F Family Genes in Lung Adenocarcinoma and Squamous Cell Carcinoma
Authors: Wang Shuo , Zhang Jun , Meng Fan-Jie , Yan Yi-Jie , Wang Bin , Guan Zhi-Yu
Published: November 2021

The E2F transcription factors family included E2F1-8 playing the crucial roles in the origination and progression of various kinds of human cancers. However, a comprehensive analysis regarding the gene mRNA expression pattern at bulk and single-cell resolution, the prognostic values and the association to immune cell infiltration of E2F family genes in lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) remains to be performed. The bulk and single-cell mRNA expression levels of E2F family members in LUAD and LUSC were determined using the cBioPortal, Gepia, TISCH and Oncomine online databases. Based on the differentially expressed genes, GO enrichment and GSEA items were investigated. The Kaplan‑Meier plotter server was used to evaluate the prognostic significances of the E2F family genes in patients with LUAD and LUSC based on the related clinicopathological features. The correlation between E2F family gene expression and immune cell infiltration was explored using the Timer database. Our bulk and single-cell RNA analyses revealed that E2F1, E2F2 and E2F8 might promote the tumor growth and aggressiveness of LUAD and LUSC indicating the poor prognosis prediction. E2F4 and E2F6 might be considered as the potential outcome markers for the improved treatment of LUAD and LUSC, respectively. Upregulation of E2F1 and E2F8 indicated the poor prognosis of LUAD patients, whereas only E2F2 overexpression was associated with shorter overall survival of LUSC patients. There existed a positive relationship between E2F8 expression level and infiltration level of macrophages and DCs, and significantly positive correlation between infiltration level of CD8+ T, CD4+ T cells and E2F1/2/7 expression in LUAD and LUSC. In conclusion, our findings suggested that increased expression of E2F1/E2F8 or E2F2 may serve as promising prognostic biomarkers for patients with LUAD or LUSC, respectively.
Location Prediction with Personalized Federated Learning
Authors: wang shuang , Wang Bowei , Yao Shuai , Qu Jiangqin , Pan Yuezheng
Published: November 2021

Location prediction has attracted wide attention in human mobility prediction because of the popularity of location-based social networks. Existing location prediction methods have achieved remarkable development in centrally stored datasets. However, these datasets contain privacy data about user behaviors and may cause privacy issues. A location prediction method is proposed in our work to predict human movement behavior using federated learning techniques in which the data is stored in different clients and different clients cooperate to train to extract useful users’ behavior information and prevent the disclosure of privacy. Firstly, we put forward an innovative spatial-temporal location prediction framework(STLPF) for location prediction by integrating spatial-temporal information in local and global views on each client, and propose a new loss function to optimize the model. Secondly, we design a new personalized federated learning framework in which clients can cooperatively train their personalized models in the absence of a global model. Finally, the numerous experimental results on check-in datasets further show that our privacy-protected method is superior and more effective than various baseline approaches.
Infection of West African Dwarf Rams With Trypanosoma Brucei Brucei and Trypanosoma Congolense Significantly Alter Serum Electrolytes, Redox Balance, Sperm Parameters, And Gonadal Morphology
Authors: Anyogu Davinson Chuka , Shoyinka Shodeinde Vincent O. , Ihedioha John Ikechukwu
Published: November 2021

Trypanotolerance of the West African dwarf (WAD) breeds may not rule out significant pathophysiological changes that may affect productivity. In this study, the effects of infection of WAD rams with Trypanosoma brucei brucei (Tbb) and Trypanosoma congolense (Tc) on their serum levels of electrolytes [calcium, phosphorus, sodium, potassium]; oxidative stress markers [superoxide dismutase (SOD), malondialdehyde (MDA)]; and sperm parameters [sperm count, motility, vitality, and morphology] were investigated. Fifteen WAD rams, assigned to 3 groups (A, B & C) of 5 rams each, were used for the study. Group A rams were infected with Tbb, while Group B rams were infected with Tc, both intraperitoneally, at the dose of 106 trypanosomes/animal. Group C rams served as the uninfected control. The infections were monitored for 70 days. Serum calcium levels were significantly (p < 0.05) lower in Tbb and Tc infected rams compared to the control throughout the study. Serum sodium was significantly (p < 0.05) higher in the Tb infected rams compared to the Tc infected and control rams on days 14 and 28 PI. Serum SOD activity decreased while MDA levels increased in both infected groups of rams. Tbb infected rams were azoospermic, while Tc infected rams had lower sperm motility, vitality and concentration and higher number of abnormal sperm cells compared to the control. Necrotic and inflammatory lesions occurred in the testis and epididymis of both infected rams. These results suggest that in spite of trypanotolerance, trypanosome infections in the WAD rams significantly impact on health and reproduction.
10-Hz tACS Over The Prefrontal Cortex Improves Phonemic Fluency
Authors: Sun Ya , Hua Qiaoling , Huang Lihui , Liu Qiang
Published: November 2021

Verbal fluency is an important indicator of human verbal ability. Methods to improve fluency is an interesting issue necessitating investigation. To do this, the current study required participants to randomly receive transcranial alternating current stimulation (tACS) at 10 Hz, 40 Hz (control frequency), and sham stimulation over the prefrontal cortex before a phonemic fluency task. It was found that 10-Hz tACS significantly improved phonemic fluency relative to sham stimulation. This result demonstrates the modulatory effect of 10-Hz tACS on language ability.
A Qualitative Assessment of Gender Roles and Implications for Child Nutrition in Central Malawi
Authors: Mkandawire Elizabeth , Bisai Clement , Dyke Elizabeth , Dressel Anne , Kantayeni Hazel , Molosoni Billy , Kako Peninnah M , Gondwe Kaboni , Mkandawire-Valhmu Lucy
Published: November 2021

Child malnutrition persists globally. While progress in reducing stunting has been witnessed over the last six years, this progress is not sufficient to meet Sustainable Development Goal targets on stunting. In Africa, child malnutrition is estimated to result in between 1.6 to 16% losses in gross domestic product. Undernutrition is also attributed as a cause of death for 11% of African children aged five years and below. Men and women play distinct roles in supporting a child's nutrition. Women frequently carry the bulk of the workload related to food, care, and health, all of which are critical factors in child nutrition. Using focus group discussions and individual interviews with communities in rural Central Malawi, we sought to understand the roles played by men and women in achieving child nutrition in this qualitative study. We found that both men and women were involved in productive, reproductive, and community work. However, consistent with the literature, women carried a disproportionate workload in supporting child nutrition compared to men. Women's heavier workloads often prevented them from being able to meet children's food needs. Nevertheless, shifts in gender roles were observed in some of the sampled communities, with men taking up responsibilities that have been typically associated with women. This undoing of gender roles did not necessarily increase women's power within the household. Improving gender equality and child nutrition will require efforts to redistribute gendered work and encourage men to move towards shared power over household decision-making and control over income with women.
Effective Mathematical Modelling of Health Passes During a Pandemic
Authors: Hohenegger Stefan , Cacciapaglia Giacomo , Sannino Francesco
Published: November 2021

We study the impact on the epidemiological dynamics of a class of restrictive measures that are aimed at reducing the number of contacts of individuals who have a higher risk of being infected with a transmittable disease. Such measures are currently either implemented or at least discussed in numerous countries worldwide to ward off a potential new wave of COVID-19. They come in the form of Health Passes (HP), which grant full access to public life only to individuals with a certificate that proves that they have either been fully vaccinated, have recovered from a previous infection or have recently tested negative to SARS-Cov-2. We develop both a compartmental model as well as an epidemic Renormalisation Group approach, which is capable of describing the dynamics over a longer period of time, notably an entire epidemiological wave. Introducing different versions of HPs in this model, we are capable of providing quantitative estimates on the effectiveness of the underlying measures as a function of the fraction of the population that is vaccinated and the vaccination rate. We apply our models to the latest COVID-19 wave in several European countries, notably Germany and Austria, which validate our theoretical findings.
Coexistence of Craniopharyngioma and Cranial Fibrous Dysplasia: A Clinicopathological Study of 5 Cases and Literature Review
Authors: Fan Yang-Hua , LI ZHI
Published: November 2021

Background: Craniopharyngioma (CP) and cranial fibrous dysplasia (CFD) are both rare embryonic benign cranial diseases that most commonly present during childhood or adolescence. Co-existence of CP and CFD is extremely rare, which has never been reported before.Methods: We retrospectively reviewed the data of 5 patients coexisted with CP and CFD in Beijing Tiantan Hospital from January 2003 to January 2021. Their clinicopathological features, treatment modalities, and outcomes were summarized. Moreover, a comprehensive literature review was conducted, and in order to explore the potential connection leading to this coexistence, the CFD characteristic GNAS gene and corresponding Gsα protein were tested in the CPResults: There were 4 males and 1 female (median age, 39 years) in the present series. The symptoms mainly included headache, dizziness, fatigue, polyuria/polydipsia, hypogonadism and blurred vision. Sphenoidal bone is the most common involved bone by CFD (n =4). Four patients had undergone surgery to remove the CP (1 transsphnoid and 3 transcranial). Complete and subtotal resection were achieved in 2 cases respectively. The tumor subtypes were 3 adamantinomatous, 1 unknown subtype. The common postoperative complications are pan-hypopituitarism, diabetes insipidus, and hypothyroidism. The mean follow-up time was 57.2 months. Postoperative hormone replacement was required in 2 patients. 3 patients underwent a genetic study of tumor specimens. GNAS mutations were not detected, but they were positive for Gsα protein. Conclusions: Though the definite causative relationship has not been proved, the coexistence of CP and CFD should not completely be excluded potential interplay or atypical FD course for the uncommon manifestations of CPs. Prompt diagnosis and appropriate treatment are more challenging than for solitary CPs for the deformations of skull base, as of now, management strategies are aimed at surgical treating the CP and regularly monitoring the CFD.
Establishment of a Finite Element Model of Supination-external Rotation Ankle Joint Injury and Analysis of Mechanical Changes in the Posterior Malleolar Surface
Authors: Zhang Xin , Xie Pinliang , Shao Weirong , Xu Ming , Xu Xiaoping , Yin Yong , Fei Lan
Published: November 2021

BackgroundBy establishing a three-dimensional finite element model of supination and external rotation ankle injury, the stress characteristics of the posterior ankle joint surface can be obtained, and complete analysis of the corresponding stress on the lateral ankle can be examined. MethodsThin-layer computed tomography (CT) images of normal ankle joints in the supination and external rotation non-weight-bearing states were selected, a three-dimensional data model of each ankle joint, including the ligament, was established, and whether different degrees of injury were coexistent with lateral ankle fracture was analysed by the finite element method. A load was applied to examine different ankle joint stress values and pressure distributions on the surface of the posterior ankle joint. ResultsWhen a load was applied, the maximum stress was located at the point of attachment of the anterior tibiofibular ligament to the tibia. When the anterior tibiofibular ligament was removed and the lateral malleolus was intact, the maximum stress (271.2 MPa) was located at the attachment point of the posterior tibiofibular ligament to the tibia, and the maximum pressure of the posterior ankle joint surface was 2.626 MPa. When a lateral malleolus fracture was present and the same load was applied, the maximum stress (82 MPa) was located on the fibular fracture surface, and the maximum pressure of the posterior ankle joint surface was 7.787 MPa. The posterior tibiofibular ligament was then removed completely from the lateral malleolus, and the maximum stress (132.7 MPa) was located at the point of attachment of the posterior tibiofibular ligament to the fibula, and the maximum pressure of the posterior ankle joint surface was 4.505 MPa. When a lateral malleolar fracture was present, the maximum stress (82.72 MPa) was located on the fibular fracture surface, and the maximum pressure of the posterior ankle joint surface was 8.022 MPa. ConclusionThis study shows that reconstruction of the lateral malleolus in supination-external rotation ankle injury significantly affects the stress distribution at the posterior malleolar joint surface. When reconstruction of the lateral malleolus is complete, the pressure distribution of the posterior malleolar joint surface can be significantly reduced. The results highlight the significance of reconstruction of posterior malleolar fractures and posterior tibiofibular ligament stability.