bluuebunny/crossref_metadata_2025 huggingface dataset:
New Approaches for the Synthesis of Heterocyclic Compounds Corporating Benzo[d]imidazole as Anticancer Agents, Tyrosine, Pim-1 Kinases Inhibitions and their PAINS Evaluations
Authors: Mohareb Rafat M. , Milad Yara R. , Mostafa Bahaa M. , El-Ansary Reem A.
Published: July 2020

Background:

Benzo[d]imidazoles are highly biologically active, in addition, they are considered as a
class of heterocyclic compounds with many pharmaceutical applications.

Objective:

We are aiming in this work to synthesize target molecules that possess not only anti-tumor activities
but also kinase inhibitors. The target molecules were obtained starting from the benzo[d]imidazole derivatives
followed by their heterocyclization reactions to produce anticancer target molecules.

Methods:

The 1-(1H-benzo[d]imidazol-2-yl)propan-2-one (3) and the ethyl 2-(1H-benzo[d]imidazol-2-
yl)acetate (16) were used as the key starting material which reacted with salicylaldehyde to give the corresponding
benzo[4,5]imidazo[1,2-a]quinoline derivatives. On the other hand, both of them were reacted with different
reagents to give thiophene, pyran and benzo[4,5]imidazo[1,2-c]pyrimidine derivatives. The synthesized compounds
were evaluated against the six cancer cell lines A549, HT-29, MKN-45, U87MG, SMMC-7721, and
H460 together with inhibitions toward tyrosine kinases, c-Met kinase and prostate cancer cell line PC-3 using
the standard MTT assay in vitro, with foretinib as the positive control.

Results:

Most of the synthesized compounds exhibited high inhibitions toward the tested cancer cell lines. In
addition, tyrosine and Pim-1 kinases inhibitions were performed for the most active compounds where the variation
of substituent through the aryl ring and heterocyclic ring afforded compounds with high activities. Our
analysis showed that there is a strong correlation between the structure of the compound and the substituents of
target molecules.

Conclusion:

Our present research proved that the synthesized heterocyclic compounds with varieties of substituents
have a strong impact on the activity of compounds. The evaluations through different cell lines and
tyrosine kinases indicated that the compounds were the excellent candidates as anticancer agents. This could
encourage doing further research within this field for the building of compounds with high inhibitions.
Combination of Salinomycin and AZD3463 Reveals Synergistic Effect on Reducing the Viability of T98G Glioblastoma Cells
Authors: Asik Aycan , Ay Neslihan P.O. , Bagca Bakiye G. , Caglar Hasan O. , Gunduz Cumhur , Avci Cigir B.
Published: July 2020

Background:

Salinomycin, an ionophore antibiotic, is known to be an effective agent in reducing the
viability of Glioblastoma (GBM) cells. The combination of salinomycin with other chemotherapeutic drugs
would help to overcome the drug resistance of GBM cells.

Objective:

This study aims to test the combinatorial effect of salinomycin and AZD3463 in T98G GBM cells.

Methods:

The cytotoxic effects of drugs on T98G GBM cells were determined by using WST-8 assay. Flow
cytometry was used to identify apoptosis and cell cycle profiles after treatments. Real-time PCR was used to
portray mRNA expression profiles of genes in the Wnt-signaling pathway after treatments.

Results:

IC50 concentrations of AZD3463 and salinomycin were 529nM and 7.3μM for 48h, respectively. The
combination concentrations of AZD3463 and salinomycin were 3.3μM and 333nM, respectively. The combination
treatment showed a synergistic effect on reducing the viability of GBM cells. AZD3463, salinomycin, and
their combination induced apoptosis in 1.2, 1.4, and 3.2 folds, respectively. AZD3463 and the combination
treatment induced the cell cycle arrest at the G1 phase. Salinomycin and AZD3463 treatments, either alone or in
combination, resulted in the downregulation or upregulation of mRNA expression levels of genes in the Wntsignaling
pathway.

Conclusion:

Salinomycin, AZD3463, and their combination may inhibit proliferation and induce apoptosis in
GBM cells due to a decrease in expression levels of genes acting in both the canonical and non-canonical Wnt
signaling pathways. The Wnt signaling pathway may be involved in salinomycin-AZD3463 drug interaction.
Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle
Authors: Das Biswajit , Kundu Chanakya N.
Published: July 2020

Quinacrine (QC) is a tricyclic compound and a derivative of 9-aminoacridine. It has been widely used
to treat malaria and other parasitic diseases since the last century. Interestingly, studies have revealed that it also
displays anti-cancer activities. Here, we have discussed the anti-cancer mechanism of QC along with its potentiality
to specifically target cancer stem cells. The anti-cancer action of this drug includes DNA intercalation,
inhibition of DNA repair mechanism, prevention of cellular growth, cell cycle arrest, inhibition of DNA and
RNA polymerase activity, induction of autophagy, promotion of apoptosis, deregulation of cell signaling in
cancer cells and cancer stem cells, inhibition of metastasis and angiogenesis. In addition, we have also emphasized
on the synergistic effect of this drug with other potent chemotherapeutic agents and mentioned its different
applications in anti-cancer therapy.
Pulsatilla saponin A Induces Apoptosis and Differentiation of Myeloma Cells
Authors: Ye Bibo , Zhou Yingying , Liu Yanli , Li Xuewei , Li Tianyu , Qi Xiaofei
Published: July 2020

Objectives:

To investigate the performance of Pulsatilla saponin A (PsA) in Multiple Myeloma
(MM) cells.

Methods:

Proliferation, cell cycle analysis, apoptosis and TUNEL assays were conducted to detect the growth
and apoptosis in MM cells. Western blotting was used to identify the change in the protein.

Results:

In cell assays, PsA significantly inhibited the growth and apoptosis in MM cells. Cyclin B1, caspase-3,
cleaved-caspase-3, PARP, cleaved-PARP, p-ERK increased, while Bcl-2 decreased after PSA treatment. The
CD49e positive rate of U266 cells was increased after 96h PsA treatment. At the same time, immunoglobulin
and the Free Light Chain (FLC) ratio in the culture supernatant obviously increased. Also, the differentiation
induced by PsA was confirmed in the primary myeloma cells.

Conclusions:

Our findings reveal that PsA may exert its antitumor effect by causing G2 arrest and apoptosis in
myeloma cells. And low-dose PsA can induce the differentiation of myeloma cell lines and primary myeloma
cells, probably through the MEK/ERK signaling pathway in vitro.
Thieno[2,3-d]pyrimidin-4(3H)-one Derivatives of Benzimidazole as Potential Anti- Breast Cancer (MDA-MB-231, MCF-7) Agents
Authors: Dimov Stefan , Mavrova Anelia Ts. , Yancheva Denitsa , Nikolova Biliana , Tsoneva Iana
Published: July 2020

Aims:

The purpose was the synthesis of some new thienopyrimidines derivative of 1,3-disubstituted
benzimidazoles and the evaluation of their cytotoxicity towards MDA-MB-231 and MCF-7 cell lines as well 3T3 cells.

Background:

An overexpression or mutational activation of TK receptors EGFR and HER2/neu are characteristic for
tumors. It has been found that some thieno[2,3-d]pyrimidines exhibit better inhibitory activity against epidermal growth
factor receptor (EGFR/ErbB-2) tyrosine kinase in comparison to aminoquinazolines. Breast cancer activity towards MDAMB-231 and MCF-7 cell lines by inhibiting EGFR was revealed by a novel 2-arylbenzimidazole. This motivated the
synthesis of new thienopyrimidines possessing benzimidazole fragment in order to evaluate their cytotoxicity to the above
mentioned cell lines.

Objective:

The objectives of the study were to design and synthesize a novel series of thieno[2,3-d]pyrimidines
bearing biologically active moieties, such as 1,3-disubstituted-benzimidazole heterocycle, structurally similar to
diaryl ureas in order to evaluate their cytotoxicity against MDA-MB-231, and MCF-7 breast cancer cell lines.

Methods:

N,N-disubstituted benzimidazole-2-one carbonitriles were synthesized by Aza-Michael addition and
used as precursors to generate some of the new thieno[2,3-d]pyrimidines in acidic medium The interaction of
chloroethyl-2-thienopyrimidines, 2-amino-benzimidazole and benzimidazol-2-one nitriles under solid-liquid
transfer catalysis conditions led to new thienopyrimidines. MTT assay for cell survival was performed in order
to evaluate the cytotoxicity of the tested compounds. A fluorescence study was conducted to elucidate some
aspects of the mechanism of action.

Results:

The effects of nine synthesized compounds were investigated towards MDA-MB-231, MCF-7 and 3T3
cell lines. Thieno[2,3-d]pyirimidine-4-one 16 (IC50 - 0.058μM) and 21 (IC50 - 0.029μM) possess high cytotoxicity
against MDA-MB-231 cells after 24h. The most cytotoxic compounds against breast cancer MCF-7 cells was
compound 21 (IC50 - 0.074μM), revealing lower cytotoxicity against mouse fibroblast 3T3 cells with IC50 - 0.20μM.
SAR analysis was performed. Fluorescence study of the treatment of MDA-MB cells with compound 21 was
carried out in order to clarify some aspects of the mechanism of action.

Conclusion:

The relationship between cytotoxicity of compounds 14 and 20 against MCF-7 and 3T3 cells can suggest a
similar mechanism of action. The antitumor potential of the tested compounds proves the necessity for further
investigation to estimate the exact inhibition pathway in the cellular processes. The fluorescence study of the treatment of
MDA-MB cells with compound 21 showed a rapid process of apoptosis.
Targeting Signalling Cross-Talk between Cancer Cells and Cancer-Associated Fibroblast through Monocarboxylate Transporters in Head and Neck Cancer
Authors: Chandel Vaishali , Kumar Dhruv
Published: July 2020

Head and Neck Squamous Cell Carcinoma (HNSCC) is an aggressive malignancy affecting more
than 600,000 cases worldwide annually, associated with poor prognosis and significant morbidity. HNSCC
tumors are dysplastic, with up to 80% fibroblasts. It has been reported that Cancer-Associated Fibroblasts
(CAFs) facilitate HNSCC progression. Unlike normal cells, malignant cells often display increased glycolysis,
even in the presence of oxygen; a phenomenon known as the Warburg effect. As a consequence, there is an
increase in Lactic Acid (LA) production. Earlier, it has been reported that HNSCC tumors exhibit high LA levels
that correlate with reduced survival. It has been reported that the activation of the receptor tyrosine kinase, c-
MET, by CAF-secreted Hepatocyte Growth Factor (HGF) is a major contributing event in the progression of
HNSCC. In nasopharyngeal carcinoma, c-MET inhibition downregulates the TP53-Induced Glycolysis and
Apoptosis Regulator (TIGAR) and NADPH production resulting in apoptosis. Previously, it was demonstrated
that HNSCC tumor cells are highly glycolytic. Further, CAFs show a higher capacity to utilize LA as a carbon
source to fuel mitochondrial respiration than HNSCC. Earlier, we have reported that in admixed cultures, both
cell types increase the expression of Monocarboxylate Transporters (MCTs) for a bidirectional LA transporter.
Consequently, MCTs play an important role in signalling cross-talk between cancer cells and cancer associate
fibroblast in head and neck cancer, and targeting MCTs would lead to the development of a potential therapeutic
approach for head and neck cancer. In this review, we focus on the regulation of MCTs in head and neck cancer
through signalling cross-talk between cancer cells and cancer-associated fibroblasts, and targeting this signalling
cross talk would lead to the development of a potential therapeutic approach for head and neck cancer.
A Personalized Voice-Based Diet Assistant for Caregivers of Alzheimer Disease and Related Dementias: System Development and Validation
Authors: Li Juan , Maharjan Bikesh , Xie Bo , Tao Cui
Published: July 2020

Background

The world’s aging population is increasing, with an expected increase in the prevalence of Alzheimer disease and related dementias (ADRD). Proper nutrition and good eating behavior show promise for preventing and slowing the progression of ADRD and consequently improving patients with ADRD’s health status and quality of life. Most ADRD care is provided by informal caregivers, so assisting caregivers to manage patients with ADRD’s diet is important.

Objective

This study aims to design, develop, and test an artificial intelligence–powered voice assistant to help informal caregivers manage the daily diet of patients with ADRD and learn food and nutrition-related knowledge.

Methods

The voice assistant is being implemented in several steps: construction of a comprehensive knowledge base with ontologies that define ADRD diet care and user profiles, and is extended with external knowledge graphs; management of conversation between users and the voice assistant; personalized ADRD diet services provided through a semantics-based knowledge graph search and reasoning engine; and system evaluation in use cases with additional qualitative evaluations.

Results

A prototype voice assistant was evaluated in the lab using various use cases. Preliminary qualitative test results demonstrate reasonable rates of dialogue success and recommendation correctness.

Conclusions

The voice assistant provides a natural, interactive interface for users, and it does not require the user to have a technical background, which may facilitate senior caregivers’ use in their daily care tasks. This study suggests the feasibility of using the intelligent voice assistant to help caregivers manage patients with ADRD’s diet.
Can Robots Improve Testing Capacity for SARS-CoV-2?
Authors: Cresswell Kathrin , Ramalingam Sandeep , Sheikh Aziz
Published: July 2020

There is currently increasing interest internationally in deploying robotic applications for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing, as these can help to reduce the risk of transmission of the virus to health care staff and patients. We provide an overview of key recent developments in this area. We argue that, although there is some potential for deploying robots to help with SARS-CoV-2 testing, the potential of patient-facing applications is likely to be limited. This is due to the high costs associated with patient-facing functionality, and risks of potentially adverse impacts on health care staff work practices and patient interactions. In contrast, back-end laboratory-based robots dealing with sample extraction and amplification, that effectively integrate with established processes, software, and interfaces to process samples, are much more likely to result in safety and efficiency gains. Consideration should therefore be given to deploying these at scale.
Hazards of the Cytokine Storm and Cytokine-Targeted Therapy in Patients With COVID-19: Review
Authors: Quirch Miguel , Lee Jeannie , Rehman Shabnam
Published: July 2020

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged medicine and health care on a global scale. Its impact and frightening mortality rate are in large part attributable to the fact that there is a lack of available treatments. It has been shown that in patients who are severely ill, SARS-CoV-2 can lead to an inflammatory response known as cytokine storm, which involves activation and release of inflammatory cytokines in a positive feedback loop of pathogen-triggered inflammation. Currently, cytokine storm is one of the leading causes of morbidity and mortality in SARS-CoV-2, but there is no proven treatment to combat this systemic response.

Objective

The aim of this paper is to study the cytokine storm response in SARS-CoV-2 and to explore the early treatment options for patients who are critically ill with the coronavirus disease (COVID-19) in the early stages of the pandemic by reviewing the literature.

Methods

A literature review was performed from December 1, 2000, to April 4, 2020, to explore and compare therapies that target cytokine storm among SARS-CoV-2 and prior coronavirus cases.

Results

A total of 38 eligible studies including 24 systematic reviews, 5 meta-analyses, 5 experimental model studies, 7 cohort studies, and 4 case reports matched the criteria.

Conclusions

The severity of the cytokine storm, measured by elevated levels of interleukin-1B, interferon-γ, interferon-inducible protein 10, and monocyte chemoattractant protein 1, was associated with COVID-19 disease severity. Many treatment options with different targets have been proposed during the early stages of the COVID-19 pandemic, ranging from targeting the virus itself to managing the systemic inflammation caused by the virus and the excessive cytokine response. Among the different agents to manage cytokine storm in patients with COVID-19, there is developing support for convalescent plasma therapy particularly for patients who are critically ill or mechanically ventilated and resistant to antivirals and supportive care. Treatment options that were proposed in the beginning phases of the pandemic were multidimensional, and further research is needed to develop a more established treatment guideline.
How Data Analytics and Big Data Can Help Scientists in Managing COVID-19 Diffusion: Modeling Study to Predict the COVID-19 Diffusion in Italy and the Lombardy Region
Authors: Tosi Davide , Campi Alessandro
Published: July 2020

Background

COVID-19 is the most widely discussed topic worldwide in 2020, and at the beginning of the Italian epidemic, scientists tried to understand the virus diffusion and the epidemic curve of positive cases with controversial findings and numbers.

Objective

In this paper, a data analytics study on the diffusion of COVID-19 in Italy and the Lombardy Region is developed to define a predictive model tailored to forecast the evolution of the diffusion over time.

Methods

Starting with all available official data collected worldwide about the diffusion of COVID-19, we defined a predictive model at the beginning of March 2020 for the Italian country.

Results

This paper aims at showing how this predictive model was able to forecast the behavior of the COVID-19 diffusion and how it predicted the total number of positive cases in Italy over time. The predictive model forecasted, for the Italian country, the end of the COVID-19 first wave by the beginning of June.

Conclusions

This paper shows that big data and data analytics can help medical experts and epidemiologists in promptly designing accurate and generalized models to predict the different COVID-19 evolutionary phases in other countries and regions, and for second and third possible epidemic waves.
Implementing Web-Based Therapy in Routine Mental Health Care: Systematic Review of Health Professionals’ Perspectives (Preprint)
Authors: Davies Fiona , Shepherd Heather L , Beatty Lisa , Clark Brodie , Butow Phyllis , Shaw Joanne
Published: July 2020

BACKGROUND

Web-based therapies hold great promise to increase accessibility and reduce costs of delivering mental health care; however, uptake in routine settings has been low.

OBJECTIVE

Our objective in this review was to summarize what is known about health care professionals’ perceptions of the barriers to and facilitators of the implementation of web-based psychological treatments in routine care of adults in health care settings.

METHODS

We searched 5 major databases (MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library) for qualitative, quantitative, or mixed-methods studies exploring health professionals’ views on computer- or internet-based psychological treatment programs. We coded included articles for risk of bias and extracted data using a prepiloted extraction sheet.

RESULTS

We identified 29 eligible articles: 14 qualitative, 11 quantitative, and 4 mixed methods. We identified the following themes: patient factors, health professional factors, the therapeutic relationship, therapy factors, organizational and system factors, and models of care. Health professionals supported web-based therapies only for patients with relatively straightforward, low-risk diagnoses, strong motivation and engagement, high computer literacy and access, and low need for tailored content. They perceived flexibility with timing and location as advantages of web-based therapy, but preferred blended therapy to facilitate rapport and allow active monitoring and follow-up of patients. They emphasized the need for targeted training and organizational support to manage changed workflows. Health professionals were concerned about the confidentiality and security of client data for web-based programs, suggesting that clear and transparent protocols need to be in place to reassure health professionals before they will be willing to refer.

CONCLUSIONS

Without health professionals’ support, many people will not access web-based therapies. To increase uptake, it is important to ensure that health professionals receive education, familiarization, and training to support them in incorporating web-based therapies into their practice, and to design systems that support health professionals in this new way of working with patients and addressing their concerns.

CLINICALTRIAL

PROSPERO CRD42018100869; https://tinyurl.com/y5vaoqsk
The Money Paradox
Authors: Kuntsevich Ilya V. , Libkhen Roman V.
Published: July 2020

Money has two key properties—accumulation (value) and liquidity (exchange), which results in what we define as “The Money Paradox”. In the language of Physics, money can be in either static (value, potential energy) or dynamic (exchange, kinetic energy) state, however the same money can’t be both static and dynamic at the same time because the states are mutually exclusive. In our paper we discuss the conditions under which money changes its state and how such transformations impact continuity (stability) of economics. Our goal is to identify the measures of continuity and thus sustainability of economic activity, as well as to help determine a point in time when new money must be infused into a financial system in order to maintain a continuous production and exchange of goods and services within an economic system without interruption, i.e., a financial crisis.
The Gender Issues in Uganda: An Analysis of Gender-Based Violence, Asset Ownership and Employment in Uganda
Authors: Madinah (PhD) Nabukeera
Published: July 2020

This manuscript analyzed Gender disparities in Uganda including asset ownership and employment as well as Sexual and Gender Based Violence (SGBV) and their persistence in Uganda. The study used a descriptive design with secondary data obtained from Uganda Bureau of Statistics-UBOS (2019). The study established that women are going through a lot of physical and sexual violence, and few of them are owning assets in spite of the efforts made by Government of Uganda and development partners. The study recommended need to increase on awareness in order to fight gender discrimination within the Uganda.
Out of the Jar into the World! A Case Study on Storing and Sharing Vertebrate Data
Authors: Borda Susan
Published: July 2020

In 2018, the Deep Blue Repositories and Research Data Services (DBRRDS) team at the University of Michigan Library began working with the University of Michigan Museum of Zoology (UMMZ) to provide a persistent and sustainable (i.e., non-grant funded, institutionally supported) solution for their part of the National Science Foundation’s (NSF) openVertebrate (oVert) initiative. The objective of oVert is to the digitize scientific collections of thousands of vertebrate specimens stored in jars on museum shelves and make the data freely accessible to researchers, students, classrooms, and the general public anywhere in the world. The University of Michigan (U-M) is one of five scanning centers working on oVert and will contribute scans of more than 3,500 specimens from the UMMZ collections (Erickson 2017).

In addition to ingesting scans, the project involved developing methods to work around several significant system constraints: Deep Blue Data’s file structure (flat files only, no folders) and the closed use of Specify, UMMZ’s specimen database, for specimen metadata. DBRRDS had to create a completely new workflow for handling batch deposits at regular intervals, develop scripts to reorganize the data (according to a third-party data model) and augment the metadata using a third-party resource, Global Biodiversity Information Facility (GBIF).

This paper will describe the following aspects of the UMMZ CT Scanning Project partnership in greater detail: data generation, metadata requirements, workflows, code development, lessons learned, and next steps.
Finding a Repository with the Help of Machine-Actionable DMPs: Opportunities and Challenges
Authors: Oblasser Simon , Miksa Tomasz , Kitamoto Asanobu
Published: July 2020

Finding a suitable repository to deposit research data is a difficult task for researchers since the landscape consists of thousands of repositories and automated tool support is limited. Machine-actionable DMPs can improve the situation since they contain relevant context information in a structured and machine-friendly way and therefore enable automated support in repository recommendation.

This work describes the current practice of repository selection and the available support today. We outline the opportunities and challenges of using machine-actionable DMPs to improve repository recommendation. By linking the use case of repository recommendation to the ten principles for machine-actionable DMPs, we show how this vision can be realized. A filterable and searchable repository registry that provides rich metadata for each indexed repository record is a key element in the architecture described. At the example of repository registries we show that by mapping machine-actionable DMP content and data policy elements to their filter criteria and querying their APIs a ranked list of repositories can be suggested.
DEVELOPING ENGLISH TEACHING MATERIALS FOR ACCOUNTING STUDENTS: AN ESP APPROACH
Authors: Nartiningrum Novrika , Nugroho Arif
Published: July 2020

The contextualization of teaching materials with learners’ needs is an absolute demand to achieve the success of a language learning. For this purpose, the present study aims to develop representative English materials for accounting students at IAIN Surakarta. Drawing on a research and development, this study was based on procedures adapted from Latief (2014), which followed several stages (1) need analysis; (2) prototype development; (3) experts validation; (4) field test/try-out; (5) product revision; and (6) dissemination and implementation. A questionnaire, focus group discussion, and semi-structured interview were employed to gather the data on students’ needs and material feedbacks from 147 accounting students, 3 English teachers, and the head of accounting department at IAIN Surakarta. The results revealed that the students needed English materials that were closely related to accounting and business field. This study also resulted in a developed modul consisting of eight units, each unit presents reading, speaking, and writing skills that were contextualized with the students’ needs. These results have filled the existing gap of providing representative materials to assist the students to develop their language skills in accounting and business environment.Keywords: English for Accounting, Material Development, Need Analysis, Research and Development
THE COMPARISON STUDY ON TWO-TYPES OF STUDENTS` PERSONALITY: SANGUINE AND PHLEGMATIC TOWARD THEIR ENGLISH SPEAKING ABILITY
Authors: Rakhmanina Lisa , Martina Feny , Jayadi Nevan
Published: July 2020

The study is an attempt to find out the difference between Sanguine and Phlegmatic personality toward their speaking ability. The design in this study was comparative analysis design. The samples of this study were 44 students from Faculty of Law. Personality test was carried out to decide whether the students were categorized to the group of Sanguine or Phlegmatic. Furthermore, the researcher used personal description for monologue speaking technique for testing the students speaking skills. The data were analyzed by using t-test formula to investigate whether there was significant difference result between the Sanguine and the Phlegmatic students in their speaking skill. From the result of the study, it could be concluded that there was no significant different result between the Sanguine and the Phlegmatic students toward their speaking skill. It means, there were not any better students in speaking between both Sanguine and Phlegmatic students. Those two personalities, the Sanguine and the Phlegmatic students could perform better English speaking skill through their own personal way.Keywords:  Comparison Study, Sanguine, Phlegmatic, Speaking Ability
AN ANALYSIS OF DEIXIS IN PAMUNGKAS'S "ONE ONLY" SONG LYRICS
Authors: Kusumadewi Siti , Anggraeni Anita
Published: July 2020

The aims of this research are to analyze the kinds of deixis that are used in One Only song lyrics and to find out the types of deixis that are major used in in the song lyrics. The researcher choose this song because this song is easy to listen to and got a good response from the listener. This research used qualitative research. The result of this research showed that in the One Only song lyrics there are four kinds of deixis, there are personal deixis, spatial deixis, temporal deixis and social deixis. Based on the discussion, personal deixis came as the most often appears deixis with 50 deictic words found or 92.6 %, the second is Spatial deixis (2 deictic words or 3.7 %), followed by temporal deixis and social deixis with the percentage of 1.85 % each. Keywords:        Deixis, Song Lyrics, Pamungkas
THE ANALYSIS OF ENDHOPORIC REFERENCE IN OPRAH’S INSPIRATIONAL GOLDEN GLOBAL SPEECH
Authors: Andriani Renny , Supartini Nai
Published: July 2020

The aims of the research is to know endhoporic reference in Oprah’s speech. This research use descriptive qualitative method. The writer choose a transcript about  Oprah’s speech from the website Endophoric is diveded in two types, there are anaphoric and cataphoric. The result shows that endhoporic references can be found in each paragraph in Oprah’s speech. This research found that anaphoric predominate in Oprah’s speech because she refers to something that has mentioned at before. In this study there were six sentences that referred to anaphoric reference and only one sentence referred to the cathaporic reference.  Anaphoric is the only reference related to cohesion.
Sistemas Modernos de Contabilidad
Authors: Juárez Fonseca Verónica , Pérez Paredes Alfredo , Garcia Vásquez Jorge Manuel
Published: July 2020

El libro trata de temas relevantes y actuales acerca de los sistemas, métodos y registros contables a partir de la segunda década del siglo XX.  Los primeros conocimientos vinculados a la función de la contaduría se ven reflejados en la aportación univoca que el autor consuma con la expresión al castellano, con un estilo particular elocuente y sutil, sin apartarse de los tecnicismos científicos provenientes de otro continente. Este es el primer libro de contabilidad en México, que traduce conceptos y tecnicismos del inglés (Inglaterra y Estados unidos de Norte América) al español sin descuidar las funciones y necesidades empresariales mexicanas.

Esta primera aportación, centra su objetivo en proporcionar los conocimientos al argot contable y la convergencia hacia estudios de casos de empresas reales que iniciaban sus operaciones en  México, como intento de resarcir la economía debilitada por las secuelas de la revolución mexicana. Asimismo, el libro separa la sistematización, de la practicidad hasta llegar a los resultados empresariales para la toma de decisiones de los futuros y actuales contadores de aquella época, a través estados financieros hasta hoy vigentes. Este legado permanece vigente a reserva de los cambios tecnológicos globales.
Synthesis of Consumer Society and Information Society
Authors: Leksin V. N.
Published: July 2020

The first part of the article shows that modern consumer society, with all the fairness of its negative ethical assessments, has reduced the threat of overproduction of huge volumes of similar consumer goods and, at the same time, has stimulated the creation of new places of employment. This is justified by the data on the multiple expansion of the range of products and services demanded by the consumer. The second part of the article shows the most important foundations for the functioning of the information society, which ensured its expansion beyond corporate and national borders and transformation into a global phenomenon of our time. The unique role of the Internet in “mass digitalization”, in the formation of the “digital economy” and in the constant expansion of the consumer layer of its goods and services is analyzed. In the third part of the article, the organic and complementary combination of consumer society and information society features is called the information society of consumption.
The Concept of the “Truth Decay” in a Digital Society (an Analytical Review)
Authors: Grachev M. N. , Evstifeev R. V.
Published: July 2020

The emergence of the “posttruth” phenomenon as the dominance of emotions and opinions over facts, the widespread dissemination of false information, and the rapid growth of fake news in the modern political communication space are the external manifestations of a more complex system of challenges, the basis of which lies in the changed nature of the media environment and ways of processing information by people’s minds, which, in turn, are caused by prevailing political and economic relations. This system of challenges is called “Truth Decay” and characterized by a set of four interconnected and interdependent trends in the contemporary political communication processes: the increase of the contradictions between facts and interpretations of these facts; the erasure of the differences between facts and opinions; the amplification of the opinions and personal points of view influence on the perception of facts; the drop of the mass audience confidence to the sources of information that were previously considered as authoritative. It is obvious that the indicated tendencies were appeared earlier, but their impact on the public consciousness becomes especially more significant and noticeable with the advent of the “digital era”. There is reason to consider that this indicated impact in a certain extent may be due to the premeditated efforts of some political actors pursuing their own interests. The authors are analyzed the recently published results of studies conducted by specialists of the RAND Corporation, which are clearly demonstrated the erosion of the civil discourse and con- vincingly explain it from the standpoint of the “Truth Decay” concept. This research area is innovative for the modern political science and is so far based solely on the analysis of the materials concerned to American realities. However, the authors are believed that the results reached by the scientists from the USA are more general and this conclusions can be used for the study of the modern political communication in processes other countries.
“Hybrid Threats” to Russia’s Security: Identification and Counteraction
Authors: Kodaneva S. I.
Published: July 2020

In the scientific literature, it is customary to consider and analyze war exclusively as a violent (conventional) confrontation of subjects of international politics. However, this does not take into account that modern wars are increasingly unfolding in the “grey zone”, that is, outside the framework of international law, they are conducted both in physical and in other dimensions – informational, cybernetic, cultural, cognitive – and mainly by non-military means and with the involvement of irregular formations (rebels, terrorists, etc.). As a result, today’s interstate confrontation is becoming more complex and hybrid, presenting new mechanisms for non-nuclear deterrence.

It is important to understand that the inability to recognize the enemy’s ongoing war in time, to determine the direction of the strike destroyed many states, starting with the Roman Empire and ending with the USSR. This determines the relevance and timeliness of this study, which is aimed at analyzing the content of the phenomenon of hybrid war, determining the main methods of its conduct used today and proposing counteraction measures.

It should be recognized that in the modern scientific literature there is no single approach to understanding what a hybrid war is, which is quite understandable precisely because of its essence – the variability and complexity of ways of it conducting, as well as flexibility and adaptability to specific circumstances. There are quite a lot of disparate studies on individual components of hybrid war, such as “soft power”, information, economic and cyberwar, “color revolutions”, etc.

The subject of this research is the phenomenon of hybrid warfare, its content and specific ways of conducting hybrid warfare. The purpose of this work is to conduct a comprehensive analysis of the subject of research, as well as to structure the manifestation that form the phenomenon of hybrid war in its complex, determine their correlation and mutual influence of various methods of conducting hybrid war, as well as to develop specific proposals for countering threats to Russia’s national security.

The importance of developing comprehensive strategic approaches aimed primarily at identifying vulnerabilities, as well as including spiritual security as the basis of the entire security system and countering hybrid threats is emphasized.

Taking into account the specified subject and purpose, the introduction reveals the relevance of the study of the phenomenon of hybrid war and the danger that this type of interstate confrontation poses for Russia. Then we analyze the concept of hybrid war and its content, as well as the four main ways of conducting it. The results of the analysis are followed by conclusions and proposals on countering threats to Russia’s national security.
Trends of Government Communications in Digital Public Sphere of Russia: 2011-2020
Authors: Filatova O. G.
Published: July 2020

The paper presents the results of two studies conducted in the early 2010s and early 2020th, which allow us to identify trends in the development of state communications in the digital public sphere of Russia. The studies were carried out on the same series using the same methods with some adjustments. The sites of all Russian public authorities at the federal level, as well as state communications in social media, were analyzed with an interval of 9 years. State communications are understood as communicative relations, the subject of which is the state as a whole, a state institution or a public authority, and which can be labeled as state PR. The subject of state communications is relations regarding the governing of state power. Comparing the results of two studies of state communications in Russia, the author analyzes the changes over the decade and draws conclusions about the active, but ineffective development of such communications that do not allow citizens to actively participate in political decision-making processes, as well as the ambiguous development of the digital public sphere of modern Russia in general. The wide interactive possibilities of modern social media which imply the priority of intermutual communication remain generally unclaimed. Despite the growth of channels, tools, services provided by modern Internet technologies, they are used by public authorities mainly for informational purposes only, without facilitating two-way communication with the population and therefore do not lead to a significant improvement in the image of power.
INION’s Library as a “Mirror” of the Social Sciences Development in Russia: From the First Socialist Experiments to the Modern Digital Age
Authors: Kuznetsov A. V. , Yurchenkova L. V.
Published: July 2020

The article deals with the modern specifics of digitization of the fundamental library functioning in one of the leading Russian scientific institutes for social sciences – Institute of Scientific Information for Social Sciences of the Russian Academy of Sciences (INION). It is shown that after the fire in January 2015, the INION’s library never stopped to work. Nowadays, more than 3 million books and journals are available to readers in 18 departments at academic institutions in Moscow. INION receives mandatory copies of Russian publications and new foreign books and journals due to international exchange. Other funds are still preserved in the warehouse due to insufficient funding from the Russian Ministry of Science and Higher Education, but after moving to a new building on the historical site on Nakhimovsky Prospekt in Moscow, the INION’s library will expand its opportunities for readers. In preparation for this move, several digitization projects are being implemented at once in INION – from the development of famous bibliographic databases, which are still in commercial demand not only in Russia but also abroad, to the digitization of books and the creation of electronic catalogues of the library. The authors draw parallels between the modern objectives and methods of the modernization of the INION’s library in accordance with the challenges of the digital era and specifics of creation of the Library at the Socialist Academy of Social Sciences (which after several reorganizations in 1969 originated the INION) by difficult financial and political conditions of 1920-30-ies. It is concluded that any steps towards digitalization should be focused primarily on the needs of readers (postgraduates, researchers and university teachers) and not based on the proposals of technocrats who have little idea in which direction social and humanitarian sciences are developing. The ultimate goal of the development of the INION’s library should be to increase the competitiveness of scientific products of Russian social scientists in the world.
Features of Functioning and Development of Network Scientific Journals in the Modern Digital Landscape System: Russian and Bulgarian Experience Comparative Analysis
Authors: Yakovleva A. F. , Mavrodieva I. T. , Boldin V. A.
Published: July 2020

The article analyzes the experience of development of electronic scientific journals in Russia and Bulgaria in the context of general trends of digitalization and transformation of the sphere of science management in recent decades and also the implementation of a strategy to increase the competitiveness of science in the global scientific community, which is reflected in the activities of scientific journals. The main problem that draws attention of the authors is how universal digitalization changes the usual view of science, affecting the development of periodicals, and how, on the contrary, the network form of social institutions of science affects its development, what place such journals occupy in the general view of science. The article examines the potential of journals in Russia and Bulgaria to promote the achievements of scientists, increase the credibility of representatives of individual scientific and educational institutions, meet the requirements of scientometrics, reflect the trends of transformation of the global scientific landscape, and fight against “fake” science. The object of the research is a number of journals in the fields of political science, philosophy, history, cultural studies, sociology, psychology, communications and information technologies published in Russia and Bulgaria, which originated as a network or use the network form as one of the main ones in their activities. The main method used in the study is an expert survey. The guide of the expert interview includes 18 questions in Russian and Bulgarian. A total of 12 interviews are conducted with editors-in-chief and members of editorial boards of 9 Russian journals, and 8 interviews with editors-in-chief of Bulgarian journals. The comparative analysis reveals similarities and differences in the goal setting of creating electronic journals, their advantages and disadvantages, the role of scientometrics, the choice of access forms and technological solutions for communication, and development prospects. The role of electronic journals in the digital socialization of scientists – authors, editors, and reviewers, and in the transformation of the usual forms of research activities of modern researchers is shown. The question of the key role of electronic journals in the fundamental change in the global scientific landscape at the same time identifies the problem of the crisis of confidence in e-magazines related to as with tradition, accepted by the scientific community, and with inadequate understanding of goal setting of electronic periodicals and their differences from print publications.
Determinan Kemiskinan Rumah Tangga di Jawa Timur
Authors: Erlando Angga , Haryanto Tri , Rositawati Verliana
Published: July 2020

This study aims to determine the economic, demographic, and social characteristics that are determinants of poverty, and analyze how the level of tendency (probability) in shaping poverty in East Java. Using a quantitative approach, this research relies on a logistical model (logit). The logit model aims to find the probability of an event occurring, in this case the probability of a household heading into poverty or not. The result is that education of household heads, gender of household heads, household size, household head work sector, access to KUR, and access to poor health insurance have a tendency to be determinants for household heading to poverty status. Educational variables, gender of the head of household, and access to KUR from this paper empirically show a tendency to reduce the probability of households to poor. Meanwhile increasing household size, types of employment in the agricultural sector, and the ownership of poor health insurance tend to increase theprobability of households heading into poverty status.
ICCPR Article 27 as a Basis for Multilingual Library Services: Implications of Treaty Implementation in the US Context
Authors: MoChridhe Race
Published: July 2020

In response to a rapidly diversifying population, American libraries have invested considerable effort in improving collections and services in non-English languages. For the past decade, the American Library Association’s Guidelines for the Development and Promotion of Multilingual Collections and Services and its Guidelines for Library Services to Spanish-Speaking Library Users have represented the aspirations of the professional community to achieve best practices in this area. At the same time, a growing interest in critically aligning librarianship with human rights work has generated rich reflection on the application of the principles of the Universal Declaration of Human Rights (UDHR). Largely overlooked in this process, however, has been the International Covenant on Civil and Political Rights (ICCPR) which, in contrast to the UDHR, is legally binding on states parties and has been ratified by the United States. This article examines the implications of ICCPR Article 27’s guarantees of cultural and language rights for minorities on the provision of non-English library collections and services, arguing that the treaty provides a legal foundation for library advocacy to support the work envisioned in the ALA’s guideline documents.
The Provision and Sustainability of GIS Services
Authors: Gao Wenli , Wang Yongming
Published: July 2020

This paper presents a case study of how one academic library provides services and support for the Geographic Information System (GIS) needs of students and faculty. The case study involves an American university library that has provided GIS services to meet the needs of students and faculty while lacking the formal position of a dedicated GIS Librarian. The library’s variety of GIS-related support is described in the paper, and an overview of resources for librarians to develop their GIS skills is also shared. The paper offers insights and lessons learned about the level of services that can be offered by academic libraries in GIS-related research and training for students, faculty, and staff.