bluuebunny/crossref_metadata_2025 huggingface dataset:
Η διαμόρφωση της οικονομικής κλίμακας χορηγικών πακέτων σε ευρωπαϊκές ποδοσφαιρικές ομάδες ανάλογα με τη δυναμική τους στα νέα μέσα
Authors: Γκανάς Παναγιώτης
Published: December 2022

Σε μια εποχή όπου η προώθηση υπηρεσιών και προϊόντων μεταβάλλεται καθημερινά, με κύρια δίοδο τα νέα Μέσα (social media, digital media, websites, blogs), ένας νέος ορίζοντας οικονομικής σχέσης ανάμεσα σε χορηγούς και χορηγούμενους έχει παγιωθεί. Τα παραδοσιακά Μέσα, όπως η τηλεόραση, το ραδιόφωνο, οι εφημερίδες και τα περιοδικά έχτισαν τις δομές για την προώθηση μέσω Media και χωρίς αυτά δεν θα υπήρχε η οδός για την έναρξη χορηγιών και μέσα από τα New Media (σ.σ. νέα Μέσα). Η μεταπήδηση στα νέα τεχνολογικά μοντέλα, ήταν προδιαγεγραμμένη και αυτό είναι κάτι που εντοπίστηκε εγκαίρως από διαφημιστικές εταιρείες, ομάδες, αθλητές και το κυριότερο από τα ίδια τα Μέσα κοινωνικής δικτύωσης. Tο καταναλωτικό κοινό που παραδοσιακά ενημερωνόταν για προϊόντα και υπηρεσίες από πηγές επικοινωνίας όπως η τηλεόραση, το ραδιόφωνο, τις εφημερίδες, έχει στραφεί πλέον στο διαδίκτυο. Βασικό στόχο της εργασίας αποτελεί η αξιολόγηση και διερεύνηση της άρρηκτης σχέσης μεταξύ εταιρειών και ομάδων ώστε να εκτιμηθεί η επίδραση των social media στον τομέα του αθλητικού μάρκετινγκ. Ειδικότερο σκοπό αποτελεί η κατανόηση της χορηγίας, εξετάζοντας τις επιπτώσεις της ομαδικής προσκόλλησης/σύνδεσης, της εκλαμβανόμενης σκοπιμότητας (και της ειλικρίνειας) και της αθλητικής ομάδας, εστιάζοντας στην κατανάλωση από τα μέσα κοινωνικής δικτύωσης σε συμπεριφορές προς χορηγούς και προθέσεις για αγορά προϊόντων (Plumley et al. 2019).Για τους παραπάνω λόγους διερευνήθηκε το πλήθος likes-followers, η κατάταξη και τα έσοδα 10 ποδοσφαιρικών ομάδων κατά τα έτη 2015 - 2020. Αυτό πραγματοποιείται μέσω μιας εις βάθος βιβλιογραφικής ανασκόπησης του θέματος συνδυαστικά με τη διενέργεια έρευνας με την μορφή συγκέντρωσης και ανάλυσης πληροφοριών που προκύπτουν από τους επίσημους λογαριασμούς στα Social Media των επιλεγμένων επαγγελματικών ποδοσφαιρικών συλλόγων, τις μελέτες για τα έσοδα των επαγγελματικών ποδοσφαιρικών ομάδων που διεξάγονται και δημοσιεύονται κάθε χρόνο από τη συμβουλευτική εταιρεία Deloitte, και τέλος πληροφορίες και στατιστικά στοιχεία για τον κλάδο του ποδοσφαίρου αλλά και τους ισολογισμούς των ομάδων.Από τα αποτελέσματα της έρευνας φάνηκε πως η ραγδαία ανάπτυξη των κοινωνικών μέσων με τη σαφή επέκταση τους και στο χώρο - βιομηχανία του αθλητισμού, όπως το ποδόσφαιρο, σε συνδυασμό με την αυξημένη κάλυψη σε πλατφόρμες κοινωνικής δικτύωσης, όπως το Instagram, το Twitter ή και το Facebook συνέβαλαν στην εξέλιξη της σχέσης μεταξύ οπαδών, φιλάθλων και αθλητικών ομάδων. Τα ευρήματα δείχνουν ότι η αφοσίωση των ατόμων σε επίπεδο φιλάθλων - οπαδών μέσω κοινωνικών δικτύων είναι μια πολυδιάστατη δομή που διακρίνεται από πολλούς και μερικές φορές και σύνθετους παράγοντες.
Carotenoids from female Grapsus albolineatus as potential anti-ageing compounds
Authors: Paransa Darus Saadah Johanis , Kemer Kurniati , Mantiri Desy Maria Helena , Kepel Rene Charles , Suleman Dininurilmi Putri , Soemantri Ara Deani , Kurnia Dikdik
Published: December 2022

Introduction: Grapsus albolineatus is thought to have a high concentration of carotenoid pigments. Although studies on male G. albolineatus have been conducted, no studies on pigment extraction from female G. albolineatus have been carried out. Carotenoids have a high ability to fight free radicals. Previous research has shown that carotenoids can fight free radicals that cause premature skin-aging. The purpose of this research was to find out what kinds of carotenoids are found in G. albolineatus and whether they can act as natural inhibitors of proteins that cause premature aging, such as glucogenase, elastase, and hyaluronidase enzymes.

Methods: Carotenoids were extracted from G. albolineatus using column chromatography and high-performance liquid chromatography (HPLC); molecular docking and visualization were done with Autodock 4.2 and Discovery Studio/Biovia, respectively.  

Results: According to HPLC data, there are carotenoid pigments such as didehydroastaxanthin, tetrahydroastaxanthin, dihydroastaxanthin, diatoxanthin, astaxanthin, and adonixanthin.  According to molecular docking experiments, pigment carotenoids from G. albolineatus are efficient inhibitors of protein elastase and hyaluronidase.

Conclusions: G. albolineatus carotenoids have the potential to be anti-aging since they are more effective as protein elastase and hyaluronidase inhibitors than their native inhibitors.
Case Report: An exceptionally large spindle cell lipoma of the popliteal fossa
Authors: Elafram Rafik , Ben Romdhane Majdi , Khessairi Nayssem , Ben Rjeb Sarra , Toumi Saif , Sghaier Majdi
Published: December 2022

Background: Spindle cell lipoma (SCL) is an uncommon subtype of lipomas. It usually occurs in the posterior side of the trunk such as neck, back and shoulders and rarely touches the extremities. Only four cases of SCL of the knee and no cases of SCL of the popliteal fossa have been reported in the literature. We present herein the largest case of SCL of the popliteal fossa and knee to our knowledge.

Case presentation: A 75-year-old woman presented with a slow growing swelling of the left knee. Physical examination showed a 12 cm well-limited painless mass of the left popliteal fossa. The mass was pediculated with a central ulceration. MRI scan showed a tumoral mass of the left popliteal fossa with some non-dilated vessels draining to the long saphenous vein. The mass had no evidence of invasion of the underlying tissues. The patient underwent a surgical resection of the mass with postoperative recovery. The histological examination revealed a tumoral proliferation diffusely expressing CD34 without malignancy evidence, and a Ki67 proliferation index <1%. This morphological and immunohistochemical aspect is typical of a SCL.

Clinical discussion: SCL is a rare histological variant of lipoma occurring mostly in the posterior side of the upper trunk. SCL of the knee or the popliteal fossa are exceptional. Clinically, it presents as a gradually increasing painless mass with a long evolving history. Histologically, these tumors are made of spindle-shaped cells, rope-like collagen fibers and mature adipocytes surrounded by a fibrous capsule. Immunohistologically, spindle cell lipomas usually show diffuse and strong expression of CD34, and to a lesser degree vimentin. The optimal treatment of SCL is a surgical marginal resection.

Conclusions: SCL represents an infrequent subtype, and its atypical presentation should push clinicians to further investigations in order to rule out more worrisome malignancies.
Metodologiczne problemy związane z badaniem związków polityki z prawem
Authors: Blok Zbigniew
Published: December 2022

Badania nad relacjami między polityką i prawem mają bogatą tradycję, cieszą się sporym zainteresowaniem i mają przed sobą znaczące perspektywy. Nie oznacza to jednak, że udało się przezwyciężyć wszystkie problemy o charakterze metodologicznym – a jest to warunek niezbędny do prowadzenia takich wspólnych badań politologiczno-prawniczych, które będą rzetelne i efektywne poznawczo. W artykule podjęto się rozważenia głównych wyzwań metodologicznych, które powinny zostać przezwyciężone, jeśli badania politologów i prawników mają stworzyć nową jakość badań społecznych. Autor wyraża przy tym sceptyczne stanowisko wobec możliwości integracji wiedzy w obliczu różnic przedmiotowych między prawem i polityką.
O prawnym makiawelizmie polityków
Authors: Karwat Mirosław
Published: December 2022

Coraz bardziej rozległa i zarazem „zagęszczona” jest sfera zjawisk związana z naruszaniem prawa w działaniach politycznych, ignorowaniem ograniczeń i zakazów prawnych, nadużywaniem prawa w walce politycznej i ideologicznej oraz w procesach rządzenia. Tym drastycznym zaprzeczeniom praworządności zwykle towarzyszy ostentacyjne bezprawie, „łamanie prawa polityką”, mniej lub bardziej zręczna, finezyjna lub żenująco niewyrafinowana dezinterpretacja lub (kiedy to wygodne) nadinterpretacja norm prawnych. W artykule przedstawiono zarys modelu pewnej nowej jakości, która zasługuje na miano specjalne – makiawelizmu prawnego. Jest to zaledwie szkic wstępny schematu pojęciowo-interpretacyjnego, zasługujący jednak – jak sądzi autor – na krytyczną weryfikację i ewentualne uściślenia.
Czym jest, a czym nie jest władza. Uwagi na marginesie normatywizacyjnej teorii władzy
Authors: Pałecki Krzysztof
Published: December 2022

Artykuł powstał na podstawie monografii autora pt. Teoria władzy. Niniejsze opracowanie dostarcza kompleksowych teoretycznych objaśnień dotyczących zjawiska władzy. Jest to studium teoretyczne, którego ustalenia pozwalają lepiej zrozumieć przedmiotowy fenomen, a także oferują założenia ontologiczne i epistemologiczne gotowe do dalszych badań zarówno teoretycznych, jak i empirycznych. Przedstawione rozumienie władzy stanowi dowód niezbędności zintegrowanych badań politologiczno-prawniczo-socjologicznych.
Over Four Centuries of Relations between the Netherlands and Türkiye
Authors: Zweiffel Łukasz , Langer Beata
Published: December 2022

The year 2012 marked the 400th anniversary of the establishment of diplomatic relations between the Netherlands and Türkiye. The history of Dutch-Turkish relations presented in the work is a synthetic description of the mutual relations between the two countries. In the political relations between the Republic of the Seven United Netherlands and Türkiye, in addition to the commercial reasons characteristic to the Republic, it was the existence of a common enemy that united the countries, although over the course of four centuries, it was the commercial relations that dominated over the political ones. In the historical outline presented, it can be seen that the activities of the two countries proceeded quite smoothly, however, the recent history may bring a greater number of conflicts related to migration.
The Attitude of New Political Parties in Poland towards Religion and the Catholic Church Based on the Example of Left-Wing Parties
Authors: Kancik-Kołtun Ewelina , Wallner Michał , Michalczuk-Wlizło Marta
Published: December 2022

In recent years, the issue of the relationships between the state and the Catholic Church has been increasingly present in public discourse in Poland. New political parties have become embroiled in the debate, taking diverse stances. The paper discusses the attitude of new political parties in Poland towards religion and the Catholic Church, using three groupings as examples: the Palikot Movement [Ruch Palikota], Robert Biedroń’s Spring [Wiosna Roberta Biedronia] and the Together Party [Partia Razem]. The authors, using content analysis as the research method, reviewed the party policies and media statements made by politicians on the topic. The aim of the article is to investigate the positions taken by selected political parties towards religion and the Catholic Church and to verify the hypothesis that the new left-wing parties advocate a strict separation of church and state.
Democratic Backsliding in Poland: The Importance of the Values of Liberal Democracy and the Rule of Law in Polish-American Relations
Authors: Jureńczyk Łukasz
Published: December 2022

: Reforms implemented in recent years by the Polish government of Law and Justice party are described as a manifestation of democratic backsliding. Changes in the judiciary and the media are seen as the main signs of departing from the basic values ​​of liberal democracy and the rule of law. They met with strong international criticism, mainly from the institutions of the European Union and Western European countries. These changes are also observed with concern in the United States, but so far the US reaction has been moderate. This was primarily due to the limited interest of President Donald Trump’s administration in promoting democracy. Later, this issue has been overshadowed by the destabilization of military security in the region. Anyway, the US reaction to the deviation of the Polish authorities from the principles of the democratic state of law must be decisive, but also constructive, based on dialogue, cooperation, clear criteria and a joint search for solutions. First of all, it must not violate the American security guarantees towards Poland.
The Issue of Poland’s Dependence on Natural Gas Supplies from the Russian Federation in the Political Thought of Piotr Naimski: Selected Problems
Authors: Paszkowski Michał
Published: December 2022

The topic of the research was the political thought of Piotr Naimski in the field of reducing Poland’s dependence on natural gas supplies from the Russian Federation. The aim of the article was therefore to analyse Naimski’s views on the diversification of the sources and directions of natural gas supplies to Poland and to define the political concepts formulated by this politician. The article indicates Naimski’s views on increasing Poland’s energy security by realizing energy projects such as LNG terminal, Baltic Pipe gas pipeline, as well as activities aimed at counteracting the Russian Federation energy policy in Central Europe. Naimski was one of the staunchest opponents of the construction of Russian-German gas pipelines (Nord Stream and Nord Stream 2).
Training and development of learning devices in the digital era at Asy-Syadzili junior high school Pakis Malang
Authors: Hariani Lilik Sri , Andayani Endah
Published: December 2022

The teaching and learning process is the core of educational activities in schools. There is an interaction between educators and students in the teaching and learning process. Good learning is possible to produce good graduates as well. The service was carried out at Asy-Syadzili Junior High School, Sumberpasir, Pakis, Malang Regency, which involved 31 teachers. Based on the results of the training preparation of learning devices in the digital era at Asy-Syadzili Junior High School, we can conclude that 85.7% of teachers understand the learning tools in accordance with the applicable curriculum; 71.4% of teachers can prepare lesson plans in the digital era; 57.1% of teachers are able to make IT-based learning media, and 57.1% of teachers are able to implement the plans and media that have been made in learning.
The empowerment of health cadres in assisting pregnant women during the covid-19 pandemic
Authors: Majdawati Ana , Brahmana Ivanna Beru
Published: December 2022

The questionnaire results on pregnant women at the Primary Health Service of Jetis II in Bantul, Yogyakarta, show that a woman contracts Covid-19. Meanwhile, other findings are that pregnant women get tired quickly (81.82%), many are not orderly to wear masks (76%), about the effects of Covid on mothers and fetuses (over 50%). Health cadres have not been optimal in assisting pregnant women in preventive and follow-up efforts. This community service program aims to empower health cadres in helping pregnant women during the pandemic by increasing knowledge "About Covid-19 for pregnant women, prevention, and management efforts". The service methods are a lecture and brainstorming activity for ten health cadres representing five hamlets. It is hoped that health cadres can become companions for pregnant women during the pandemic, as mediators in delivering health knowledge for mothers and fetuses, and also giving preventive efforts they must. Community service activities through face-to-face and online meetings in Turen Hamlet, Jetis II Community Health Center, and Bantul shows an increasing knowledge of health cadres. The discussion results before the lecture are that 35% of health cadres can answer correctly, and 85% can answer and explain accurately and adequately after the lecture. Conclusion: Efforts to increase knowledge about Covid-19 for pregnant women through health cadres' assistance are necessary to reduce the morbidity and mortality rate of mothers and fetuses.
A brief overview of cosmeceutical skincare during pregnancy
Authors: Scott Julie
Published: December 2022

Julie Scott details the most frequent skin concerns experienced during pregnancy and how these patients can be safely treated
Radiofrequency microneedling in aesthetic practice
Authors: Charlson Paul
Published: December 2022

Dr Paul Charlson discusses the use of radiofrequency microneedling for skin rejuvenation and addressing skin concerns
Combining thermal imaging and spectral pyrometry for express temperature mapping in additive manufacturing
Authors: Grishin M. Ya. , Sdvizhenskii P. A. , Asyutin R. D. , Tretyakov R. S. , Stavertiy A. Ya. , Pershin S. M. , Liu D. S. , Lednev V. N.
Published: December 2022

A compact and low-cost two-dimensional (2D) thermal imager was developed for real-time temperature mapping of a melt pool during coaxial laser cladding (the additive manufacturing technique). The device combines a color CMOS camera and a compact spectrometer. The spectrometer was utilized for internal calibration and validation of a 2D temperature map that was acquired by the CMOS camera. The remarkable feature of the thermal imager is that camera images are calibrated directly during the measurement process utilizing spectral pyrometry. Additionally, the spectrometer decreased a potential systematic error due to a spectrum contribution from atomic/ionic lines emission. The spectral pyrometry provided temperature accuracy measurements of

±

23

K

while two-dimensional (2D) temperature mapping by two-color pyrometry accuracy was estimated as

±

38

K

in the range of 1700–3500 K. The system has been installed at a coaxial laser cladding head for real-time temperature mapping. The system was developed for measuring a melt pool during laser cladding production of a high wear-resistant coating (tungsten carbide particles in a nickel matrix). Tungsten carbides powder flow rate has been changed sequentially from 5 to 27 g/min by powder feeder programming, which resulted in a variation of melt pool dimensions and temperature maps during the cladding process.
Adaptive optics scanning laser ophthalmoscopy and optical coherence tomography (AO-SLO-OCT) system for in vivo mouse retina imaging
Authors: Zhang Pengfei , Wahl Daniel J. , Mocci Jacopo , Miller Eric B. , Bonora Stefano , Sarunic Marinko V. , Zawadzki Robert J.
Published: December 2022

Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are imaging technologies invented in the 1980s that have revolutionized the field of in vivo retinal diagnostics and are now commonly used in ophthalmology clinics as well as in vision science research. Adaptive optics (AO) technology enables high-fidelity correction of ocular aberrations, resulting in improved resolution and sensitivity for both SLO and OCT systems. The potential of gathering multi-modal cellular-resolution information in a single instrument is of great interest to the ophthalmic imaging community. Although similar instruments have been developed for imaging the human retina, developing such a system for mice will benefit basic science research and should help with further dissemination of AO technology. Here, we present our work integrating OCT into an existing mouse retinal AO-SLO system, resulting in a multi-modal AO-enhanced imaging system of the living mouse eye. The new system allows either independent or simultaneous data acquisition of AO-SLO and AO-OCT, depending on the requirements of specific scientific experiments. The system allows a data acquisition speed of 200 kHz A-scans/pixel rate for OCT and SLO, respectively. It offers ∼6 µm axial resolution for AO-OCT and a ∼1 µm lateral resolution for AO-SLO-OCT imaging.
Asymmetric, non-uniform 3-dB directional coupler with 300-nm bandwidth and a small footprint
Authors: Nikbakht Hamed , Khoshmehr Mohammad Talebi , van Someren Bob , Teichrib Dieter , Hammer Manfred , Förstner Jens , Akca B. Imran
Published: December 2022

Here we demonstrate a new, to the best of our knowledge, type of 3-dB coupler that has an ultra-broadband operational range from 1300 to 1600 nm with low fabrication sensitivity. The overall device size is 800 µm including in/out S-bend waveguides. The coupler is an asymmetric non-uniform directional coupler that consists of two tapered waveguides. One of the coupler arms is shifted by 100 µm in the propagation direction, which results in a more wavelength-insensitive 3-dB response compared to a standard (not shifted) coupler. Moreover, compared to a long adiabatic coupler, we achieved a similar wavelength response at a 16-times-smaller device length. The couplers were fabricated using the silicon nitride platform of Lionix International. We also experimentally demonstrated an optical switch that is made by using two of these couplers in a Mach–Zehnder interferometer configuration. According to experimental results, this optical switch exhibits –10 dB of extinction ratio over the 1500–1600 nm wavelength range. Our results indicate that this new type of coupler holds great promise for various applications, including optical imaging, telecommunications, and reconfigurable photonic processors where compact, fabrication-tolerant, and wavelength-insensitive couplers are essential.
Seronegative MSM at high risk of HIV-1 acquisition show an immune quiescent profile with a normal immune response against common antigens
Authors: Ossa-Giraldo Ana C. , Blanquiceth Yurany , Flórez-Álvarez Lizdany , Contreras-Ramírez Katherin , Rojas Mauricio , Hernandez Juan C. , Zapata Wildeman
Published: December 2022

Human immunodeficiency virus (HIV) infection still represents a major public health problem worldwide, and its vaccine remains elusive. The study of HIV-exposed seronegative individuals (HESN) brings important information about the natural resistance to HIV, allows a better understanding of the infection, and opens doors for new preventive and therapeutic strategies. Among HESN groups, there are some men who have sex with men (MSM) with high-risk sexual behaviors, who represent an adequate cohort for HESN study because of their major HIV exposure without infection. This study aimed to compare the immunological profile of Colombian seronegative MSM with different risk sexual behaviors. This study included 60 MSM at high-risk (n = 16) and low-risk (n = 44) of HIV-1 acquisition. No sex worker nor homozygous delta 32 mutation subjects were included. All participants were negative for anti-HIV-1/2 antibodies and HIV-1 proviral DNA. A higher frequency of sexual partners in the last 3 months before the study participation (median, 30 vs. 2), lifetime sexual partners (median, 1,708 vs. 26), and unprotected anal intercourse (median 12.5 vs. 2) was determined in high-risk MSM than low-risk MSM. High-risk MSM also showed a quiescent profile of T cells and natural killer (NK) cells, with a significantly lower percentage of CD4+CD38+, CD4+HLADR−CD38+, CD4+Ki67+ T cells, and NKG2D+ NK cells (CD3−CD16+CD56+), a significantly higher percentage of CD4+HLADR−CD38−, and a tendency to show a higher percentage of CD8+HLADR+CD38− T cells than the low-risk group. Likewise, they showed higher mRNA levels of Serpin A1 from PBMCs. The results suggest that this MSM cohort could be HESN individuals and their resistance would be explained by a quiescent profile of T cells and NK cells and an increased Serpin A1 expression. Further study on MSM at high risk of exposure to HIV-1 is necessary to better understand the natural resistance to HIV.
The prognosis of lipid reprogramming with the HMG-CoA reductase inhibitor, rosuvastatin, in castrated Egyptian prostate cancer patients: Randomized trial
Authors: Karkeet Riham M. , Zekri Abdelrahman N. , Sayed-Ahmed Mohamed M. , Sherif Ghada M. , Salem Salem E. , Abdelbary Ahmed , Fouad Mariam A. , Saad Sherif Y.
Published: December 2022

Aim

The role of surgical castration and rosuvastatin treatment on lipid profile and lipid metabolism related markers was evaluated for their prognostic significance in metastatic prostate cancer (mPC) patients.

Methods

A total of 84 newly diagnosed castrated mPC patients treated with castration were recruited and divided into two groups: Group I served as control (statin non-users) while group II treated with Rosuvastatin (20 mg/day) for 6 months and served as statin users. Prostate specific antigen (PSA), epidermal growth factor receptor (EGFR), Caveolin-1 (CAV1), lipid profile (LDL, HDL, triglycerides (TG) and total cholesterol (TC)) and lipid metabolism related markers (aldoketoreductase (AKR1C4), HMG-CoA reductase (HMGCR), ATP-binding cassette transporter A1 (ABCA1), and soluble low density lipoprotein receptor related protein 1 (SLDLRP1)) were measured at baseline, after 3 and 6 months. Overall survival (OS) was analyzed by Kaplan-Meier and COX regression for prognostic significance.

Results

Before castration, HMG-CoA reductase was elevated in patients <65 years (P = 0.009). Bone metastasis was associated with high PSA level (P = 0.013), but low HMGCR (P = 0.004). Patients with positive family history for prostate cancer showed high levels of EGFR, TG, TC, LDL, alkaline phosphatase (ALP), but low AKR1C4, SLDLRP1, CAV1 and ABCA-1 levels. Smokers had high CAV1 level (P = 0.017). After 6 months of castration and rosuvastatin administration, PSA, TG, LDL and TC were significantly reduced, while AKR1C4, HMGCR, SLDLRP1, CAV1 and ABCA-1 were significantly increased. Overall survival was reduced in patients with high baseline of SLDLRP1 (>3385 pg/ml, P = 0.001), PSA (>40 ng/ml, P = 0.003) and CAV1 (>4955 pg/ml, P = 0.021).

Conclusion

Results of the current study suggest that the peripheral lipidogenic effects of rosuvastatin may have an impact on the treatment outcome and survival of castrated mPC patients.

Trail registration

This trial was registered at the Pan African Clinical Trial Registry with identification number PACTR202102664354163 and at ClinicalTrials.gov with identification number NCT04776889.
Development of a visual multiplex fluorescent LAMP assay for the detection of foot-and-mouth disease, vesicular stomatitis and bluetongue viruses
Authors: Fan Qing , Xie Zhixun , Wei You , Zhang Yanfang , Xie Zhiqin , Xie Liji , Huang Jiaoling , Zeng Tingting , Wang Sheng , Luo Sisi , Li Meng
Published: December 2022

Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique that can be used to amplify target genes at a constant temperature, and it has several advantages, including convenience, specificity and sensitivity. However, due to the special interpretation methods of this technology for reaction results, all the previously reported LAMP detection methods have been restricted to identifying a single target, which limits the application of this technology. In this study, we modified conventional LAMP to include a quencher-fluorophore composite probe complementary to the F1c segment of the inner primer FIP; upon strand separation, a gain in the visible fluorescent signal was observed. The probes could be labeled with different fluorophores, showing different colors at the corresponding wavelengths. Therefore, this multiplex LAMP (mLAMP) assay can simultaneously detect 1–3 target sequences in a single LAMP reaction tube, and the results are more accurate and intuitive. In this study, we comprehensively demonstrated a single-reaction mLAMP assay for the robust detection of three cattle viruses without nonspecific amplification of other related pathogenic cattle viruses. The detection limit of this mLAMP assay was as low as 526–2477 copies/reaction for the recombinant plasmids. It is expected that this mLAMP assay can be widely used in clinical diagnosis.
projeto de destruição está em curso
Authors: Guerra Lúcia Dias da Silva , Carnut Leonardo , Nogueira MENDES Áquilas
Published: December 2022

O objetivo deste texto é contribuir para o início de algumas reflexões sobre o momento estrutural e conjuntural sob o qual vivemos. Para isso, a saúde como um direito social e objeto de análise traz a luz o nosso campo de disputa. A pandemia do COVID- 19 elucidou que novos rumos e novas lutas devem ser travadas. Ou seguiremos na crise humanitária que vem se arrastando e agudizando a cada passo as condições materiais da classe trabalhadora.
Evaluating the TOPODATA digital elevation model as a source of information for cycling planning purposes: a case study for a small-sized Brazilian city
Authors: Monari Marcelo , Lima Segantine Paulo César , Silva Irineu da
Published: December 2022

The present study aims to evaluate the TOPODATA Digital Elevation Model (DEM) as a source of relevant altimetric information for urban cycling planning. A case study was conducted in the city of Bariri-SP. The Cartographic Accuracy Standard of Digital Cartographic Products (PEC-PCD), assessed by comparing the TOPODATA altitudes with homologous altitudes surveyed by a precise satellite method (GNSS), suggests that the DEM may not be adequate for phases of cycling planning that require greater detailing of the elements to be designed. A moderate to strong positive spatial autocorrelation was observed between the DEM errors. Regarding its usability for estimating the average slopes of the road segments, however, the results suggest that TOPODATA average slopes do not differ statistically from those estimated with field-surveyed data and, for the two criteria adopted for acceptable gradient lengths for cycling, more than 82% of the road segments were classified similarly using both sources of information.
Evaluation of Acacia- Guar Gum Combination as Delayed Release Coating Former on Solid Placebo Tablets
Authors: Alkarib Suad Y. , MohamedElhassan Deina E.
Published: December 2022

Objectives
The present study addresses evaluation of acacia-guar gum combination as an enteric former for tablet coating aiming to add knowledge on how develop the ability of enteric forming ability of acacia-guar combination.

Methods
Five formulations of enteric coating solution incorporating guar gum as delayed release polymers along with film coating material acacia gum followed by CMC and glycerin as plasticizer and coloring agents were prepared to coat placebo tablet cores. Different enteric coating formulations organized in different acacia : guar gum ratios as 1:1, 1:2, 1:3, 1:4 and 1:6 were sprayed on placebo tablets surface resulted different delayed coated tablets (F1,F2,F3,F4 &F5) respectively. General appearance and physical parameters were evaluated of each. Enteric coated tablets that revealed promising properties were subjected to accelerated stability study for 3 months to explore the influences of physical aging on tablet coat properties.

Results
Physical parameters of enteric coated tablets post coating within the range of pharmacopeia specification. The disintegration test was carried out in pH 1.2 and pH 6.8 at 37ºC. F1, F2 and F3 enteric tablets disintegrated immediately with no acid resistance compared F4 and F5 enteric tablets showed good acid resistance coat with smooth tablet surfaces and no coat defects. F5 formula contain acacia: guar gum as 1:6 ratio showed delayed release for 30min in pH 1.2 and 15min in phosphate buffer. The study statistically analyzed and concluded that, an efficient and stable acacia-guar enteric coat is achievable with no effect on tablets physical parameters. Guar gum at 60% as a delayed tablet coating material capable of protecting the tablets core from being released in acidic media and be release in the alkaline buffer as well as stable coat under accelerated storage for three months.
Correlating 13C Isotope in Oligomeric Proanthocyanidins with their Anticancer Properties
Authors: B. Little Reginald , Uziel Orit
Published: December 2022

Upon considering the anticancer effects of larger oligomeric proanthocyanidins and observing various papers reporting the high resolution mass spectroscopy of the oligomeric proanthocyanidins, it is determined that the unusual 13C enrichment in some plant oligomeric proanthocyanidins may be responsible for the anticancer activities of these food products. Such correlation of the 13C in the oligomeric proanthocyanidins also correlate with their scavenging of free-radicals, anti-virial and anti-bacterial properties. Proanthocyanidins in grape seeds are observed to have high enrichment in heavy isotopes of 2H, 13C, 15N and/or 17O. Mass analysis of DNA from human cancer cells are compared to normal human cells and cancer cells show bond specific enrichment of heavy isotopes in nucleotides G, A, T and C. On such basis, this study suggests possible stronger interactions of proanthocyanidins with DNA in cancer verses DNA in normal cells due to heavy isotope bond specific enrichments in both proanthocyanidins and the cancer DNA. Such 13C interactions from oligomeric proanthocyanidins with nucleic acids and proteins involved in replications, transcriptions and translations in cancer cells for interacting and chemically altering anabolism and cell division of the cancer cells are consistent with the author’s mechanism for normal cell to cancer cell transformations via possible replacements of primordial 1H, 12C, 14N, 16O, and 24Mg isotopes by nonprimordial 2H, 13C, 15N, and 17O and 25Mg isotopes in the proteins and nucleic acids. Such is also consistent with the proposed treatment for cancer by the author by use of foods containing proteins, nucleic acids, carbohydrates and/or drug molecules enriched with the nonprimordial isotopes of 2H, 13C, 15N, and 17O and 25Mg.
Nature Inspired Bargain Optimization Algorithm for Effective Interpretation of Geoelectrical Data
Authors: Raj Stanley , Angelena J.P. , Hariharan  , Kumar D. Senthil , Akshaya S. , Dhamodharan R.
Published: December 2022

Geoelectrical resistivity data collected from the ground contain lot of noises and errors. It requires efficient algorithm to reduce the errors to make an actual inversion models. Though different algorithm can be applied, nature inspired algorithm is more potential in inverting geoelectrical data in an elegant and comprehensive way. Bargain Optimization (BO) algorithm is framed on the concept of bargaining things to purchase for needs. In general, effective bargaining results in more profit and leads to loss when it fails. In this research work, Bargain Optimization algorithm is applied to invert geoelectrical data and the effective bargaining will take time to process and to obtain the required model. The input data is AB/2, apparent resistivity data and the inverted model through BO algorithm is successfully matched with the available litholog section of the study area. The output graphs have profit/loss bar graph, which reveals the status of bargaining during a particular number of epochs.
Preface 21-22
Authors: Milton James , Bazinas Ioannis
Published: December 2022

Preface
Front matter
Authors: Milton James , Bazinas Ioannis
Published: December 2022

Front matter
Políticas públicas e desenvolvimento rural no interior paulista: o programa de microbacias hidrográficas em municípios da região de Presidente Prudente/SP
Authors: Souza Paulo Cesar , Hespanhol Antonio Nivaldo
Published: December 2022

No Brasil, as políticas públicas direcionas aos pequenos produtores rurais e as classes menos favorecidas, começaram a ser implementadas na década de 1990. Com a redemocratização e o fortalecimento do poder municipal houve maior injeção de recursos propiciando a retração do êxodo rural e melhoria nas condições no campo. A política pública em foco é o Programa Estadual de Microbacias Hidrográficas, realizado no Estado de São Paulo entre os anos 1996 a 2007. Com o objetivo de verificar a importância do programa, procurou-se evidenciar ações no que se refere: a) acesso aos incentivos de baixo custo; b) as intervenções conservacionistas; c) infra-estruturas rural; d) manejo adequado dos recursos naturais e, e) a promoção do associativismo e da gestão compartilhada dos recursos. Contudo, constata-se que as políticas públicas são capazes de agilizar uma nova dinâmica produtiva na agropecuária regional, através de gestão participativa e envolvimento da sociedade
A Política externa brasileira a partir dos anos 90 e a participação do Ministério do Desenvolvimento Agrário nas negociações agrícolas internacionais da Rodada DOHA
Authors: Iverio Tamara Silvana Menuzzi
Published: December 2022

Neste artigo será feita uma retomada histórica dos fatos referentes à política externa brasileira, os quais ocorreram durante a gestão Collor até a gestão Lula. Busca-se, com isso, mostrar a posição assumida por esses governos com relação à política externa. Além disso, procura compreender como se deu a participação do ministério do desenvolvimento agrário na formulação da posição brasileira nas negociações agrícolas, da Rodada de Doha. Os resultados evidenciaram que houve um aumento crescente da participação de atores em assuntos de política externa e este fato vem induzindo a uma alteração no modelo decisório desse campo no Brasil, principalmente nas negociações agrícolas, antes marcado como isolado e muito limitado ao Itamaraty. Constatou-se ainda que o Ministério do Desenvolvimento Agrário buscou influenciar a posição brasileira nas negociações comerciais em defesa da agricultura familiar e da segurança alimentar.
Caracterização da piscicultura na região de Ariquemes, no Estado de Rondônia
Authors: Costa André Luis Saoncela da , Rodrigues Marilsa de Sá , Ricci Fabio
Published: December 2022

O presente estudo tem como escopo a caracterização da piscicultura na região de Ariquemes, no estado de Rondônia. A elaboração foi subsidiada por método de natureza qualitativa, e os dados foram tratados qualitativa e quantitativamente. Buscou-se identificar as características das diversas atividades piscicultoras na região e, pela análise das interações entre os diferentes atores do processo, apurou-se o potencial da atividade para o desenvolvimento da área. Os resultados conduziram ao entendimento de que uma parcela dos agentes econômicos envolvidos na atividade provieram de outras atividades econômicas, foi também detectada que a presença de agentes de financiamento são desejados e desejáveis pelos piscicultores da região, de modo que, havendo linhas de crédito apropriadas, estas serão utilizadas de modo crescente; como resultados verificados, há a percepção de que o estado é demandado quanto às suas responsabilidades de gestão pública, a falta de programas de mão de obra técnica oferece impacto sobre a qualidade da força de trabalho, os modais logísticos impactam sobre a visão de futuro dos piscicultores da região.
El territorio indígena kichwa y el desarrollo local en la amazonia ecuatoriana
Authors: Gutiérrez Ruth Irene Arias , Sorzano Angelina Herrera , Sousa Roberto González
Published: December 2022

Este artículo analiza el sistema territorial indígena Kichwa amazónico, su agro biodiversidad, caracteriza la población, valora el grado en que los recursos del territorio satisfacen las necesidades alimentarias de las familias, el uso actual de la productos provenientes de la selva y su destino, con el objetivo de proponer el principio rector a seguir en el diseÃ±o de estrategias de desarrollo local sostenible. Se usaron métodos cualitativos y cuantitativos con 64 cuestionarios aplicados en seis comunidades rurales del valle sub andino del Anzu. Las variables medidas se expresaron en porcentaje y cuantificación monetaria. Los resultados mostraron que las comunidades pierden conocimiento y uso de especies por la interacción con el frente de colonización aunque conservan la biodiversidad, considerada no solo como recursos genéticos que han de ser protegidos, sino como expresión de los principios de autonomía, conocimiento, identidad y economía. El uso doméstico de los recursos locales prevalece en las comunidades Kichwa y su destino para la venta en las comunidades con menor población Kichwa y más cercanas a la frontera de colonización. Las estrategias deben orientarse y tener como base el uso de los recursos amazónicos renovables, apoyarse en la formación de redes de investigación y colaboración respetuosa y equitativa entre comunidades y universidades del territorio, para lageneración de ciencia, cultura y arte locales.
Redes do agronegócio canavieiro: a territorialização do Grupo Tércio Wanderley no Triângulo Mineiro/Alto Paranaíba-MG
Authors: Campos Natália Lorena , Cleps Junior João
Published: December 2022

A presente pesquisa tem como objeto a atuação do Grupo Tércio Wanderley – grupo tradicional nordestino do setor sucroenergético e com atuação nas últimas décadas na região Triângulo Mineiro/Alto Paranaíba no estado de Minas Gerais. A migração deste grupo para Minas Gerais ocorre justamente no processo de reestruturação produtiva que ocorreu a partir da década de 1980. Com a análise das estratégias de ação deste grupo na região pretendemos analisar como a produção agroindustrial se organiza por meio das redes, técnicas e produtivas, dentro da lógica dos circuitos espaciais produtivos. Esta organização em rede modifica substancialmente as relações com território, sobretudo, no que tange o controle produtivo. Metodologicamente, a pesquisa foi construída a partirde levantamentos de dados a respeito do setor sucroenergético em boletins e jornais afins, estudo do Grupo Tércio Wanderley e pesquisa de campo nas unidades mineiras do grupo, onde entrevistamos funcionários, fornecedores e trabalhadores da empresa. O processo de reestruturação produtiva no setor sucroenergético levou à reorganização territorial, resultando em novos arranjos territoriais cujas redes é o elemento de amalgama, criando novas territorialidades, desterritorializando e  reterritorializando outras.
Análise dos processos de masculinização no meio rural os municípios brasileiros segundo porte populacional e grau de modernização da agropecuária
Authors: Costa Alfredo , Matos Ralfo Edmundo da Silva , Valle Matheus Henrique Fernandes
Published: December 2022

O artigo em questão tenta estabelecer uma relação causal entre o processo de masculinização da população rural e o processo de modernização conservador do campo. Isso leva a uma sobrerepresentação da população masculina em áreas rurais e emigração feminina para os centros urbanos. Para a análise da hipótese foram consultados diversos autores que trataram a questão sob uma abordagem qualitativa. Constata-se, entretanto, há insuficiência de trabalhos que abordem os grandes números que associam população e espaço. Assim, este trabalho apresenta evidenciações empíricas do impacto da modernização conservadora na reconfiguração da população rural dos municípios brasileiros por meio de dados secundários oriundos dos censos demográficos e agropecuário (IBGE), ambos produzidos entre 2000 e 2010. Os resultados demonstram forte correlação entre o processo de modernização do campo e o fenômeno da masculinização, sobretudo no território da soja, nas fronteiras agrícolas clássicas e nas novas áreas de expansão da pecuária no norte do Brasil (Rondônia, Roraima e Amapá).
A questão agrária no Pontal do Paranapanema e o debate paradigmático
Authors: Felicio Munir Jorge
Published: December 2022

A complexidade da questão agrária analisada a partir da Região do Pontal do Paranapanema está marcada pelo enfrentamento entre o capital e o campesinato visando a submissão do território, de um lado e pelo debate paradigmático visando o controle e o domínio político das interpretações e dos significados, de outro. A luta pela terra e a luta pelo conhecimento estão imbricadas. O embate no campo contribui e interfere nas disputas no "campus". A troca do "campus" universitário pelo território camponês pode, na medida do possível, diminuir a distância entre teoria e prática e, com isso propiciar também a comparação entre as diversas concepções, conceitos, correntes teóricas e visão de mundo. O debate paradigmático entre dois paradigmas: o da questão agrária que defende o protagonismo propositivo do campesinato e o seu necessário embate com o capital, pois ambos ocupam o território com lógicas distintas. E, o do capitalismo agrário que defende a dependência e a submissão ao capital como única perspectiva, defendendo a hipótese da metamorfose do camponês em agricultor familiar. Basta ao campesinato lutar ao lado do capital se tecnificando e se integrando no processo produtivo, pois não há antagonismo entre capital e campesinato.
Ruralidades na compreensão dos territórios do vinho e sua identidade
Authors: Flores Shana Sabbado , Medeiros Rosa Maria Vieira
Published: December 2022

O estudo de questões envolvendo o rural traz à tona a complexidade inerente ao conceito e tratamento do tema, impondo uma cuidadosa observação de suas relações para uma efetiva compreensão. Nesse sentido, o uso das ruralidades como categoria de análise se torna uma ferramenta importante na compreensão do rural e suas questões. A partir da abordagem das ruralidades, o trabalho analisa os atores sociais que constituem o território dos "Vinhos da Campanha" e suas perspectivas de sustentabilidade. Assim, os atores sociais foram agrupados de acordo com alguns critérios - como, relação com a cultura e a terra, meios de produção e comercialização e origem do capital investido - resultando em três categorias: (1) a vitivinicultura corporativa, (2) os empreendedores e (3) os produtores independentes. Dessa maneira pode ser observado como a relação de grupos distintos com a vitivinicultura caracteriza novas ruralidades para a Campanha Gaúcha, configurando o território dos Vinhos da Campanha. As novas ruralidades acabam por sintetizar novas formas de apropriação do espaço, novas territorialidades, agregando funcionalidades ao rural, o que aumenta sua complexidade, trazendo novas oportunidades e desafios. Ao mesmo tempo, podem ser observados fatores que ligam as novas ruralidades a princípios de sustentabilidade, dentro de um escopo social e territorial.
Produção familiar, conservação ambiental e turismo no espaço rural da microrregião de Itajubá, Minas Gerais
Authors: Andrade Alexandre Carvalho de , Ferreira Enéas Rente
Published: December 2022

O presente trabalho tem o objetivo de demonstrar as condições socioeconômicas e do uso do território na microrregião de Itajubá, Sul de Minas Gerais. Tendo em vista que as relações entre sociedade, natureza e economia estão se tornando cada vez mais complexas na sociedade pós-moderna, os territórios necessitam de ter estratégias para, assim, atingir o desenvolvimento socioeconômico e utilizar adequadamente dos seus recursos naturais. Na microrregião de Itajubá é crescente o interesse pela conservação ambiental e pelo desenvolvimento do turismo, porém, tal situação pode resultar em consideráveis impactos socioambientais aos seus moradores, em especial aos que habitam e produzem no espaço rural.
Eletroestratégias: as pequenas centrais hidrelétricas e os meandros do setor elétrico brasileiro
Authors: Albuquerque Ralph de Medeiros , Moraes George Guimarães de
Published: December 2022

As eletroestratégias podem ser definidas como um conjunto heterogêneo de discursos, de mecanismos jurídico-formais e de ações ditas empreendedoras e sustentáveis. Abrangem tanto estudos em prol do setor elétrico como suas oscilações de mercado e suas tendências, bem como de ajustes nas legislações ambiental e tributária, visando beneficiar o setor elétrico. A partir do conceito de eletroestratégia e das diferentes normativas brasileiras buscou-se evidenciar os interesses por trás das diferentes mudanças de legislação do setor elétrico, as políticas orientadas para este setor e a flexibilização da legislação ambiental. Seguindo essa mesma lógica, o Paraná tem sido alvo de um "alagamento" de Pequenas Centrais Hidrelétricas (PCHs), visando à produção de energia. Essa grande quantidade de barramentos se dá principalmente em virtude de as PCHs disporem de uma série de vantagens para serem implantadas, indo desde programas governamentais de financiamento até mudanças na legislação tanto do setor elétrico quanto do ambiental, permitindo que se faça um comparativo dos desdobramentos das eletroestratégias no caso das PCHs do Paraná.