bluuebunny/crossref_metadata_2025 huggingface dataset:
Is the Complement System Dysregulated in Preeclampsia Comorbid with HIV Infection?
Authors: Govender Sumeshree , David Mikyle , Naicker Thajasvarie
Published: June 2024

South Africa is the epicentre of the global HIV pandemic, with 13.9% of its population infected. Preeclampsia (PE), a hypertensive disorder of pregnancy, is often comorbid with HIV infection, leading to multi-organ dysfunction and convulsions. The exact pathophysiology of preeclampsia is triggered by an altered maternal immune response or defective development of maternal tolerance to the semi-allogenic foetus via the complement system. The complement system plays a vital role in the innate immune system, generating inflammation, mediating the clearance of microbes and injured tissue materials, and a mediator of adaptive immunity. Moreover, the complement system has a dual effect, of protecting the host against HIV infection and enhancing HIV infectivity. An upregulation of regulatory proteins has been implicated as an adaptive phenomenon in response to elevated complement-mediated cell lysis in HIV infection, further aggravated by preeclamptic complement activation. In light of the high prevalence of HIV infection and preeclampsia in South Africa, this review discusses the association of complement proteins and their role in the synergy of HIV infection and preeclampsia in South Africa. It aims to identify women at elevated risk, leading to early diagnosis and better management with targeted drug therapy, thereby improving the understanding of immunological dysregulation.
Numerical Investigation of the Excitation Characteristics of Contaminated Nozzle Rings
Authors: Beierl Michaela R. , Vogt Damian M. , Fischer Magnus , Müller Tobias R. , So Kwok Kai
Published: June 2024

The deposition of combustion residues in the nozzle ring (NR) of a turbocharger turbine stage changes the NR geometry significantly in a random manner. The resultant complex and highly asymmetric geometry induces low engine order (LEO) excitation, which may lead to resonance excitation of rotor blades and high cycle fatigue (HCF) failure. Therefore, a suitable prediction workflow is of great importance for the design and validation phases. The prediction of LEO excitation is, however, computationally expensive as high-fidelity, full annulus CFD models are required. Previous investigations showed that a steady-state computational model consisting of the volute, the NR, and a radial extension is suitable to reduce the computational costs massively and to qualitatively predict the level of LEO forced response. In the current paper, the aerodynamic excitation of 69 real contaminated NRs is analyzed using this simplified approach. The results obtained by the simplified simulation model are used to select 13 contaminated NR geometries, which are then simulated with a model of the entire turbine stage, including the rotor, in a transient time-marching manner to provide high-fidelity simulation results for the verification of the simplified approach. Furthermore, two contamination patterns are analyzed in a more detailed manner regarding their aerodynamic excitation. It is found that the simplified model can be used to identify and classify contamination patterns that lead to high blade vibration amplitudes. In cases where transient effects occurring in the rotor alter the harmonic pressure field significantly, the ability of the simplified approach to predict the LEO excitation is not sufficient.
Sudden Sensorineural Hearing Loss in Patients Aged from 15 to 40 Years
Authors: Aldè Mirko , Ambrosetti Umberto , Piatti Gioia , Romanini Camilla , Filipponi Eliana , Di Berardino Federica , Zanetti Diego , Pignataro Lorenzo , Cantarella Giovanna , Barozzi Stefania
Published: June 2024

Objectives: The purpose of this study was to investigate the hearing characteristics and causes of sudden sensorineural hearing loss (SSNHL) in patients aged from 15 to 40 years, focusing on audiological outcomes one year after the diagnosis. Methods: The medical records of individuals with SSNHL who were referred to our tertiary-level audiologic center were reviewed. All patients had undergone comprehensive diagnostic evaluations, including high-resolution 3D-FLAIR delayed magnetic resonance imaging (MRI), cone beam computed tomography (CBCT), and screening for coagulation, infectious, and autoimmune diseases. Results: Overall, 56 patients (mean age 28.1 ± 7.6 years) were included in the study. The hearing threshold in the affected ear improved significantly from 56.0 ± 18.0 dB at the diagnosis to 46.9 ± 22.3 dB after one year (p = 0.02). The degree of hearing loss, audiometric configurations, hearing improvements, and adherence to hearing treatments showed considerable variability among patients. Aural fullness, tinnitus, and hyperacusis were the predominant symptoms associated with SSNHL, and their prevalence decreased significantly over time. The diagnostic protocol led to the identification of the specific cause of SSNHL in 75% (42/56) of patients. The known etiology was found to be otological (39.3%), infectious (21.4%), autoimmune (7.1%), vascular (5.4%), or neoplastic (1.8%). In particular, Menière’s disease (n = 12), isolated cochlear endolymphatic hydrops (n = 6), HSV-1 (n = 5), and EBV (n = 4) infections were the most frequent causes of SSNHL. Conclusions: The identification of the specific etiology of SSNHL may facilitate a more personalized approach to management and treatment.
Practical Considerations of Remote Care in Thoracic Aortopathy in India
Authors: Grewal Nimrat , Idhrees Mohammed , Velayudhan Bashi , Klautz Robert J. M. , Grewal Simran
Published: June 2024

Background: Thoracic aortopathy includes conditions like aortic aneurysms and dissections, posing significant management challenges. In India, care delivery is complicated by geographic vastness, financial constraints, and healthcare resource disparities. Telemedicine and digital health technologies offer promising solutions. Methods: A comprehensive review of literature and clinical experiences was conducted to explore the implementation of remote care strategies for thoracic aortopathy in India. The review included studies from 2000 to 2023 and insights from cardiothoracic specialists. Results: Remote care benefits include improved access to specialized expertise, enhanced patient engagement, and optimized resource utilization. Telemedicine enables consultations without travel, and remote monitoring facilitates early intervention. However, challenges like technology integration, digital literacy, patient engagement, privacy concerns, and regulatory compliance need addressing. Discussion: Telemedicine offers significant advantages but requires overcoming challenges to ensure effective, secure care. Careful planning for technology integration, patient education, robust privacy measures, and supportive regulatory policies are essential. Addressing these issues can bridge the healthcare access gap and improve outcomes in India’s diverse landscape.
Flexor Tendon Continuity and Negative X-ray: The “Combo” Negative Features in Finger Subamputation
Authors: Pugliese Pierfrancesco , Vulpetti Mariangela , Tondini Greta , Toia Francesca
Published: June 2024

Background: The subamputation of fingers with vascular compromise presents a surgical challenge. Although tissue continuity may be considered a favourable prognostic element, in our experience, we noticed that there is not always a direct correlation between soft tissue involvement, radiographic appearance and final outcome. Methods: We included, in our study, all cases of vascular pedicle injury in which finger salvage was attempted with microsurgical revascularisation. Exclusion criteria were: integrity of both vascular pedicles, pedicle lesion without global circulatory compromise and patients treated immediately with amputation. Results: Between May 2018 and July 2023, 27 male patients with finger subamputation injuries were treated at our institution. In 11 cases of injured fingers, the only intact tissue was the flexor digitorum profundus (FDP) or flexor pollicis longus (FPL). Our global failure rate was 49%; whereas, in the subgroup of the 11 cases with continuity of the FDP or FPL, the failure rate rose to 73% and when the fingers showed flexor tendon integrity and radiographs demonstrated minimal bone damage, revascularisation failure was observed in all cases (100%). Conclusions: The results of the study show that subamputations with devascularisation, clinically presented with the combination of flexor tendon as the only element of tissue continuity and dislocation or minimal bone/articular injury, have a worse prognosis because of their trauma mechanism. We propose to add them to the Kay-Adani Classification as a subset of the poorest prognostic injuries group (III), to help surgeons to make decisions about the management of subamputation finger injuries.
Minimally Invasive Direct Coronary Artery Bypass Grafting: Sixteen Years of Single-Center Experience
Authors: Weymann Alexander , Amanov Lukman , Beltsios Eleftherios , Arjomandi Rad Arian , Szczechowicz Marcin , Merzah Ali Saad , Ali-Hasan-Al-Saegh Sadeq , Schmack Bastian , Ismail Issam , Popov Aron-Frederik , Ruhparwar Arjang , Zubarevich Alina
Published: June 2024

Background: Coronary artery disease is a major cause of death globally. Minimally invasive direct coronary artery bypass (MIDCAB), using a small left anterior thoracotomy, aims to provide a less invasive alternative to traditional procedures, potentially improving patient outcomes with reduced recovery times. Methods: This retrospective, non-randomized study analyzed 310 patients who underwent MIDCAB between July 1999 and April 2022. Data were collected on demographics, clinical characteristics, operative and postoperative outcomes, and follow-up mortality and morbidity. Statistical analysis was conducted using IBM SPSS, with survival curves generated via the Kaplan–Meier method. Results: The cohort had a mean age of 63.3 ± 10.9 years, with 30.6% females. The majority of surgeries were elective (76.1%), with an average operating time of 129.7 ± 35.3 min. The median rate of intraoperative blood transfusions was 0.0 (CI 0.0–2.0) Units. The mean in-hospital stay was 8.7 ± 5.5 days, and the median ICU stay was just one day. Early postoperative complications were minimal, with a 0.64% in-hospital mortality rate. The 6-month and 1-year mortalities were 0.97%, with a 10-year survival rate of 94.3%. There were two cases of perioperative myocardial infarction and no instances of stroke or new onset dialysis. Conclusions: The MIDCAB approach demonstrates significant benefits in terms of patient recovery and long-term outcomes, offering a viable and effective alternative for patients suitable for less invasive procedures. Our results suggest that MIDCAB is a safe option with favorable survival rates, justifying its consideration in high-volume centers focused on minimally invasive techniques.
Can Farmland Transfer Reduce Fertilizer Nonpoint Source Pollution? Evidence from China
Authors: Bai Ziming , Zhang Xiaochen , Xu Jiabin , Li Cuixia
Published: June 2024

China repeatedly surpasses international fertilizer safety limits, resulting in significant fertilizer nonpoint source pollution (denoted as FNSP), which adversely affects food security and agricultural sustainability. Simultaneously, farmland transfer has emerged as a pivotal strategy for transitioning between agricultural production methods. The present study aims to investigate the relationship between farmland transfer and FNSP. In line with the aim of the study, based on China’s panel data from 2005 to 2020, the fixed-effect model, mediating-effect model, spatial Durbin model, and threshold regression model are employed. The findings reveal that farmland transfer exerts a significant inhibitory effect on FNSP. The reduction in FNSP through farmland transfer is facilitated by the decrease in fertilizer application intensity and increase in compound fertilizer application. Further, farmland transfer demonstrates a significant spatial spillover effect on FNSP, mitigating pollution levels within regions and influencing neighboring areas. Moreover, a nonlinear relationship between farmland transfer and FNSP is observed. These findings contribute to understanding the intricate dynamics between agricultural land management strategies and environmental sustainability, offering valuable insights for policymakers and stakeholders engaged in promoting green and sustainable agricultural practices.
Quantitative Evaluation and Evolution Characteristics of Consistency Level of Black Soil Conservation Policy, Taking China’s Black Soil Protection Policy as an Example
Authors: Zhang Fan , Han Peng , Wu Ling , Tian Zhanwei
Published: June 2024

Scientifically evaluating China’s black soil protection policy and exploring its evolution characteristics are crucial for promoting high-quality and efficient black soil protection projects worldwide. Utilizing the Policy Modeling Consistency (PMC) index model, the effectiveness of China’s black soil protection policy system is assessed. Building upon this evaluation, the research delves into the evolution process of the black soil protection policy system, examining its dynamic characteristics across different government levels. Through the application of text mining technology and visual analysis techniques, the study explores four dimensions: keyword co-occurrence, vertical synergy calculation, policy theme identification, and policy tool analysis. The results show the following: (1) The PMC index showed a phased growth trend, and various indicators gradually improved and tended to be stable. (2) Government policies at the same level exhibit progressive evolution patterns in terms of policy keywords and themes. (3) Across different levels of government, there are hierarchical lag evolution rules observed in policy keywords and provincial policy tools. Additionally, policy keywords display vertical synergy evolution patterns. In conclusion, future black soil conservation policies need to reduce hierarchical delays, enhance the coverage and comprehensiveness of policy content, and establish a sound policy feedback mechanism. The conclusions of the study are significant for improving management approaches throughout the black soil zones of the world.
Evolutionary Characteristics, Regional Differences and Spatial Convergence of China’s Sustainable Agricultural Development Level
Authors: Zhu Honghui , Zheng Xin
Published: June 2024

Sustainable agricultural development is a fundamental requirement and a crucial goal of modern agriculture. It is also a significant means of enabling farmers to increase their incomes. This paper analyses the evolutionary characteristics, regional differences and spatial convergence of the level of sustainable agricultural development using kernel density estimation, Dagum’s Gini coefficient and the spatial convergence model based on panel data from 30 provinces in China from 2012 to 2021.The results show that: (1) At the level of development, the level of sustainable agricultural development at the national level and in the three major regions has shown an upward trend with fluctuations, with the average level of development in the eastern and central parts of the country higher than the national average, and in the western part of the country lower than the national average; however, the growth rate in the western part of the country is the highest among the three major regions. (2) In terms of evolutionary characteristics, the level of sustainable agricultural development in the country and the three major regions is characterised by spatial agglomeration, with varying degrees of polarisation. (3) In terms of regional differences, the Gini coefficients for the country as a whole, within the three major regions and between regions, generally show a downward trend, with interregional differences remaining the main source of overall differences. (4) In terms of spatial convergence, there is σ-convergence and β-convergence in the level of sustainable agricultural development across the country and the three major regions, and there is a positive spatial spillover effect. The conditional β convergence results show that the eastern region has the fastest rate of convergence. The above findings provide a scientific basis for the formulation of policies related to sustainable agricultural development in China.
Strength of Composite Pressure Insulators for High Voltage Circuit Breakers: An Experimental and Numerical Investigation
Authors: Ferino Jan , Loi Gabriela , Meleddu Andrea , Aymerich Francesco , Mazzarelli Iuri , Pichini Elisa
Published: June 2024

Glass fiber-reinforced composite cylinders, capable of withstanding internal pressure generated during service, are increasingly utilized as insulators in high voltage circuit breakers. Different testing procedures have been suggested by various standards to assess the pressure resistance of these components. Due to its simplicity and cost-effectiveness, the split-disk testing method is the most widely used for evaluating the hoop strength of pressure cylinders during the development and verification phases. However, the method presents several aspects, such as those related to the influence of specimen geometry and friction, which require further examination since they may impact the outcome of the experimental tests. The investigation, carried out by a combination of experimental testing and finite element analyses, shows that the friction between the specimen and the semi-disks has a noteworthy effect on the hoop load applied to the specimen. Almost constant load distributions along the hoop direction, representative of the real operating conditions in a pressurized cylinder, can be achieved via proper lubrication of the contact surfaces. Furthermore, FE analyses demonstrate that the notch geometry suggested by specific standards (short notch) is not capable of inducing a uniform strain distribution in the notched region. A different notch geometry (long notch) is proposed in the study to attain a more uniform strain field over the reduced area region. The experimental results indicate that the strength measured on the short notch specimens is higher than that determined on the long notch specimens, thus confirming the significant influence of strain distribution on the strength properties measured with the split-disk method.
Long-Term Thermal Stabilization of Poly(Lactic Acid)
Authors: Hallstein Jannik , Metzsch-Zilligen Elke , Pfaendner Rudolf
Published: June 2024

To use polylactic acid in demanding technical applications, sufficient long-term thermal stability is required. In this work, the thermal aging of polylactic acid (PLA) in the solid phase at 100 °C and 150 °C is investigated. PLA has only limited aging stability without the addition of stabilizers. Therefore, the degradation mechanism in thermal aging was subsequently investigated in more detail to identify a suitable stabilization strategy. Investigations using nuclear magnetic resonance spectroscopy showed that, contrary to expectations, even under thermal aging conditions, hydrolytic degradation rather than oxidative degradation is the primary degradation mechanism. This was further confirmed by the investigation of suitable stabilizers. While the addition of phenols, phosphites and thioethers as antioxidants leads only to a limited improvement in aging stability, the addition of an additive composition to provide hydrolytic stabilization results in extended durability. Efficient compositions consist of an aziridine-based hydrolysis inhibitor and a hydrotalcite co-stabilizer. At an aging temperature of 100 °C, the time until significant polymer chain degradation occurs is extended from approx. 500 h for unstabilized polylactic acid to over 2000 h for stabilized polylactic acid.
TRAF6 Inhibitors from Marine Compound Library: Pharmacophore, Virtual Screening, Fragment Replacement, ADMET, and Molecular Dynamics
Authors: Wu Xuexuan , Zhong Saiyi , Zhou Nan , Luo Lianxiang
Published: June 2024

TRAF6 is an E3 ubiquitin ligase that plays a crucial role in cell signaling. It is known that MMP is involved in tumor metastasis, and TRAF6 induces MMP-9 expression by binding to BSG. However, inhibiting TRAF6’s ubiquitinase activity without disrupting the RING domain is a challenge that requires further research. To address this, we conducted computer-based drug screening to identify potential TRAF6 inhibitors. Using a ligand–receptor complex pharmacophore based on the inhibitor EGCG, known for its anti-tumor properties, we screened 52,765 marine compounds. After the molecular docking of 405 molecules with TRAF6, six compounds were selected for further analysis. By replacing fragments of non-binding compounds and conducting second docking, we identified two promising molecules, CMNPD9212-16 and CMNPD12791-8, with strong binding activity and favorable pharmacological properties. ADME and toxicity predictions confirmed their potential as TRAF6 inhibitors. Molecular dynamics simulations showed that CMNPD12791-8 maintained a stable structure with the target protein, comparable to EGCG. Therefore, CMNPD12791-8 holds promise as a potential inhibitor of TRAF6 for inhibiting tumor growth and metastasis.
The Complement System as a Therapeutic Target in Retinal Disease
Authors: Ong Joshua , Zarnegar Arman , Selvam Amrish , Driban Matthew , Chhablani Jay
Published: June 2024

The complement cascade is a vital system in the human body’s defense against pathogens. During the natural aging process, it has been observed that this system is imperative for ensuring the integrity and homeostasis of the retina. While this system is critical for proper host defense and retinal integrity, it has also been found that dysregulation of this system may lead to certain retinal pathologies, including geographic atrophy and diabetic retinopathy. Targeting components of the complement system for retinal diseases has been an area of interest, and in vivo, ex vivo, and clinical trials have been conducted in this area. Following clinical trials, medications targeting the complement system for retinal disease have also become available. In this manuscript, we discuss the pathophysiology of complement dysfunction in the retina and specific pathologies. We then describe the results of cellular, animal, and clinical studies targeting the complement system for retinal diseases. We then provide an overview of complement inhibitors that have been approved by the Food and Drug Administration (FDA) for geographic atrophy. The complement system in retinal diseases continues to serve as an emerging therapeutic target, and further research in this field will provide additional insights into the mechanisms and considerations for treatment of retinal pathologies.
The Impact of Acute EBV Infection on Changes in the Serum Proteome in Children—A Pilot Study
Authors: Mazur-Melewska Katarzyna , Luczak Magdalena , Watral Joanna , Małecki Paweł , Mania Anna , Figlerowicz Magdalena
Published: June 2024

This study investigates the impact of Epstein–Barr virus (EBV) infection on children’s proteomes across different phases of the disease, utilising seventy-nine blood samples categorised into three groups: EBV-naive patients, acute infectious mononucleosis (IM) cases, and convalescents followed up for 12 months post-IM. The aim is to identify proteins influenced by EBV infection, shedding light on the chronic processes triggered by the virus. The results reveal thirty-nine proteins distinguishing between naive patients and those with IM, including actin, lumican, peroxiredoxin-2, fibulin-1, gelsolin, and alpha-2-macroglobulin, which are involved in immune responses, cell adhesion, and inflammation. Elevated oxidative stress markers like peroxiredoxin-2 in IM patients suggest potential links to EBV’s induction of reactive oxygen species. Increased levels of apolipoproteins A-I, A-IV, C-IV, and M during IM imply associations with viral infection, while complement system proteins (C1q, C1r, and C8 gamma chain) are also elevated, reflecting their role in the immune response and viral clearance. This study’s focus on children provides unique insights into EBV’s impact on young populations, emphasising proteomics’ role in uncovering protein associations and understanding the virus’s long-term consequences. However, specific relationships between identified proteins and EBV infection require further investigation.
The Role of the Airway and Gut Microbiome in the Development of Chronic Lung Disease of Prematurity
Authors: Boel Lieve , Gallacher David J. , Marchesi Julian R. , Kotecha Sailesh
Published: June 2024

Chronic lung disease (CLD) of prematurity, a common cause of morbidity and mortality in preterm-born infants, has a multifactorial aetiology. This review summarizes the current evidence for the effect of the gut and airway microbiota on the development of CLD, highlighting the differences in the early colonisation patterns in preterm-born infants compared to term-born infants. Stool samples from preterm-born infants who develop CLD have less diversity than those who do not develop CLD. Pulmonary inflammation, which is a hallmark in the development of CLD, may potentially be influenced by gut bacteria. The respiratory microbiota is less abundant than the stool microbiota in preterm-born infants. There is a lack of clear evidence for the role of the respiratory microbiota in the development of CLD, with results from individual studies not replicated. A common finding is the presence of a single predominant bacterial genus in the lungs of preterm-born infants who develop CLD. Probiotic preparations have been proposed as a potential therapeutic strategy to modify the gut or lung microbiota with the aim of reducing rates of CLD but additional robust evidence is required before this treatment is introduced into routine clinical practice.
p-Coumaric Acid Differential Alters the Ion-Omics Profile of Chia Shoots under Salt Stress
Authors: Nkomo Mbukeni , Badiwe Mihlali , Niekerk Lee-Ann , Gokul Arun , Keyster Marshal , Klein Ashwil
Published: June 2024

p-Coumaric acid (p-CA) is a phenolic compound that plays a crucial role in mediating multiple signaling pathways. It serves as a defense strategy against plant wounding and is also presumed to play a role in plant development and lignin biosynthesis. This study aimed to investigate the physiological and ionomic effect of p-CA on chia seedlings under salt stress. To this end, chia seedlings were supplemented with Nitrosol® containing 100 μM of p-CA, 100 of mM NaCI, and their combined (100 mM NaCI + 100 μM p-CA) solutions in 2-day intervals for a period of 14 days along with a control containing Nitrosol® only. The treatment of chia seedlings with 100 mM of NaCI decreased their growth parameters and the content of the majority of the essential macro-elements (K, P, Ca, and Mg), except for that of sodium (Na). The simultaneous application of p-CA and a salt stress treatment (p-CA + NaCI) alleviated the effect of salt stress on chia seedlings’ shoots, and this was indicated by the increase in chia biomass. Furthermore, this combined treatment significantly enhanced the levels of the essential microelements Mg and Ca. In summary, this brief report is built on the foundational work of our previous study, which demonstrated that p-CA promotes growth in chia seedlings via activation of O2−. In this brief report, we further show that p-CA not only promotes growth but also mitigates the effects of salt stress on chia seedlings. This mitigation effect may result from the presence of Mg and Ca, which are vital nutrients involved in regulating metabolic pathways, enzyme activity, and amino acid synthesis.
Job Satisfaction, Mental Symptoms, and Well-Being in Adult Workers: A Gender Analysis
Authors: Matud M. Pilar , Sánchez-Tovar Ligia , Hernández-Lorenzo D. Estefanía , Cobos-Sanchiz David
Published: June 2024

Although studies have found that job satisfaction has an impact on workers’ physical and mental health, research has generally not focused on the psychological well-being of adult workers and a gender differential analysis has not been conducted. The aim of the current research is to determine the importance of job satisfaction for mental symptoms and well-being among adult working women and men. We also examine gender differences in job satisfaction. A non-probability sample of 1977 Spanish workers (51.6% men and 48.4% women) aged between 36 and 65 years was used in this cross-sectional study. Six questionnaires and self-report scales were used to assess the participants. For both men and women, higher job satisfaction was associated with lower depressive, somatic, anxiety, and social dysfunction symptoms; higher life satisfaction; and greater psychological well-being. Hierarchical multiple regression analyses showed that after controlling for the effects of self-esteem and social support, higher job satisfaction predicted greater life satisfaction, fewer mental symptoms, and greater psychological well-being, although the effect of job satisfaction on psychological well-being was somewhat stronger for men than for women. We conclude that job satisfaction is important for the mental health, psychological well-being, and life satisfaction of adult working women and men.
A Comparison of the Frequency of Trisomy 13, 18, and 21 Using Non-Invasive Prenatal Testing According to Diminished vs. Normal Egg Reserve and Age
Authors: Neumann Brooke , Weitz Nicole , Check Jerome H. , Wilson Carrie , Diantonio Ann , O’Neil Megan
Published: June 2024

Background: This study’s aim was to determine whether diminished oocyte reserve (DOR) increases the risk of having a fetus with trisomy 13, 18, or 21 at 10 weeks as evaluated by non-invasive prenatal testing (NIPT) and to evaluate the confounding effect of advanced age. Methods: NIPT was undertaken in all pregnancies conceived through natural treatment or assisted reproductive technology that reached 10 weeks from conception with a viable fetus from one infertility center. Data were stratified according to serum anti-Mullerian hormone (AMH) < 1 ng/mL and ≥1 ng/mL. Results: No woman < 39 or with AMH ≥ 1 ng/mL showed trisomy 13, 18, or 21 by NIPT. Only women ≥ age 39 with DOR had one of these trisomies. Conclusions: Hopefully these data, coupled with other factors, e.g., etiology of infertility, age, insurance, or financial circumstances, and personal views of pregnancy termination, will aid patients with DOR when choosing treatment options, including natural conception, IVF-ET, IVF with pre-implantation genetic testing for aneuploidy, or transfer of fertilized donor eggs.
Stability Study of Synthetic Diamond Using a Thermally Controlled Biological Environment: Application towards Long-Lasting Neural Prostheses
Authors: Roy Jordan , Sarah Umme Tabassum , Lissorgues Gaëlle , Français Olivier , Rezgui Abir , Poulichet Patrick , Takhedmit Hakim , Scorsone Emmanuel , Rousseau Lionel
Published: June 2024

This paper demonstrates, for the first time, the stability of synthetic diamond as a passive layer within neural implants. Leveraging the exceptional biocompatibility of intrinsic nanocrystalline diamond, a comprehensive review of material aging analysis in the context of in-vivo implants is provided. This work is based on electric impedance monitoring through the formulation of an analytical model that scrutinizes essential parameters such as the deposited metal resistivity, insulation between conductors, changes in electrode geometry, and leakage currents. The evolution of these parameters takes place over an equivalent period of approximately 10 years. The analytical model, focusing on a fractional capacitor, provides nuanced insights into the surface conductivity variation. A comparative study is performed between a classical polymer material (SU8) and synthetic diamond. Samples subjected to dynamic impedance analysis reveal distinctive patterns over time, characterized by their physical degradation. The results highlight the very high stability of diamond, suggesting promise for the electrode’s enduring viability. To support this analysis, microscopic and optical measurements conclude the paper and confirm the high stability of diamond and its strong potential as a material for neural implants with long-life use.
Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor
Authors: Dong Bing , Wei Bo , Wei Dongshan , Ke Zhilin , Ling Dongxiong
Published: June 2024

Quasi-bound state in the continuum (QBIC) can effectively enhance the interaction of terahertz (THz) wave with matter due to the tunable high-Q property, which has a strong potential application in the detection of low-concentration biological samples in the THz band. In this paper, a novel THz metamaterial sensor with a double-chain-separated resonant cavity structure based on QBIC is designed and fabricated. The process of excitation of the QBIC mode is verified and the structural parameters are optimized after considering the ohmic loss by simulations. The simulated refractive index sensitivity of the sensor is up to 544 GHz/RIU, much higher than those of recently reported THz metamaterial sensors. The sensitivity of the proposed metamaterial sensor is confirmed in an experiment by detecting low-concentration lithium citrate (LC) and bovine serum albumin (BSA) solutions. The limits of detection (LoDs) are obtained to be 0.0025 mg/mL (12 μM) for LC and 0.03125 mg/mL (0.47 μM) for BSA, respectively, both of which excel over most of the reported results in previous studies. These results indicate that the proposed THz metamaterial sensor has excellent sensing performances and can well be applied to the detection of low-concentration biological samples.
SAW Humidity Sensing with rr-P3HT Polymer Films
Authors: Jakubik Wiesław , Wrotniak Jarosław , Caliendo Cinzia , Benetti Massimiliano , Cannata Domenico , Notargiacomo Andrea , Stolarczyk Agnieszka , Kaźmierczak-Bałata Anna
Published: June 2024

In the present paper the humidity sensing properties of regioregular rr-P3HT (poly-3-hexylthiophene) polymer films is investigated by means of surface acoustic wave (SAW) based sensors implemented on LiNbO3 (1280 Y-X) and ST-quartz piezoelectric substrates. The polymeric layers were deposited along the SAW propagation path by spray coating method and the layers thickness was measured by atomic force microscopy (AFM) technique. The response of the SAW devices to relative humidity (rh) changes in the range ~5–60% has been investigated by measuring the SAW phase and frequency changes induced by the (rh) absorption in the rr-P3HT layer. The SAW sensor implemented onto LiNbO3 showed improved performance as the thickness of the membrane increases (from 40 to 240 nm): for 240 nm thick polymeric membrane a phase shift of about −1.2 deg and −8.2 deg was measured for the fundamental (~78 MHz operating frequency) and 3rd (~234 MHz) harmonic wave at (rh) = 60%. A thick rr-P3HT film (~600 nm) was deposited onto the quartz-based SAW sensor: the sensor showed a linear frequency shift of ~−20.5 Hz per unit (rh) changes in the ~5–~50% rh range, and a quite fast response (~5 s) even at low humidity level (~5% rh). The LiNbO3 and quartz-based sensors response was assessed by using a dual delay line system to reduce unwanted common mode signals. The simple and cheap spray coating technology for the rr-P3HT polymer films deposition, complemented with fast low level humidity detection of the tested SAW sensors (much faster than the commercially available Michell SF-52 device), highlight their potential in a low-medium range humidity sensing application.
A 14-Bit Hybrid Analog-to-Digital Converter for Infrared Focal Plane Array Digital Readout Integrated Circuit
Authors: Hu Douming , Yao Libin , Chen Nan , Zhang Jiqing , Zhong Shengyou , Mao Wenbiao , Zhu Fang , Zhang Juan
Published: June 2024

This paper presents a 14-bit hybrid column-parallel compact analog-to-digital converter (ADC) for the application of digital infrared focal plane arrays (IRFPAs) with compromised power and speed performance. The proposed hybrid ADC works in two phases: in the first phase, a 7-bit successive approximation register (SAR) ADC performs coarse quantization; in the second phase, a 7-bit single-slope (SS) ADC performs fine quantization to complete the residue voltage conversion. In this work, the number of unit capacitors is reduced to 1/128th of that of a conventional 14-bit SAR ADC, which is beneficial for the application of small pixel-pitch IRFPAs. In this work, a tradeoff segmented thermometer-coded digital-to-analog converter (DAC) is adopted in the first 7-bit coarse quantization process: the lower 3-bit is binary coded, and the upper 4-bit is thermometer coded. A thermometer-coded DAC can improve the linearity of ADC. Capacitor array matching can be incredibly relaxed compared with a binary-weight 14-bit SAR ADC, resulting in a noncalibration feature. Moreover, by sharing DAC and comparator analog circuits between the SAR ADC and the SS ADC, the power consumption and layout area are consequently reduced. The proposed hybrid ADC was fabricated using a 180 nm CMOS process. The measurement results show that the proposed ADC has a differential nonlinearity of −0.61/+0.84 LSB and a sampling rate of 120 kS/s. The developed ADC achieves a temporal noise of 1.7 LSBrms at a temperature of 77 K. In addition, the SNDR is 72.9 dB, and the ENOB is 11.82 bit, respectively. Total power consumption is 71 μW from supply voltages of 3.3 V (analog) and 1.8 V (digital).
MONET: The Minor Body Generator Tool at DART Lab
Authors: Buonagura Carmine , Pugliatti Mattia , Topputo Francesco
Published: June 2024

Minor bodies exhibit considerable variability in shape and surface morphology, posing challenges for spacecraft operations, which are further compounded by highly non-linear dynamics and limited communication windows with Earth. Additionally, uncertainties persist in the shape and surface morphology of minor bodies due to errors in ground-based estimation techniques. The growing need for autonomy underscores the importance of robust image processing and visual-based navigation methods. To address this demand, it is essential to conduct tests on a variety of body shapes and with different surface morphological features. This work introduces the procedural Minor bOdy geNErator Tool (MONET), implemented using an open-source 3D computer graphics software. The starting point of MONET is the three-dimensional mesh of a generic minor body, which is procedurally modified by introducing craters, boulders, and surface roughness, resulting in a photorealistic model. MONET offers the flexibility to generate a diverse range of shapes and surface morphological features, aiding in the recreation of various minor bodies. Users can fine-tune relevant parameters to create the desired conditions based on the specific application requirements. The tool offers the capability to generate two default families of models: rubble-pile, characterized by numerous different-sized boulders, and comet-like, reflecting the typical morphology of comets. MONET serves as a valuable resource for researchers and engineers involved in minor body exploration missions and related projects, providing insights into the adaptability and effectiveness of guidance and navigation techniques across a wide range of morphological scenarios.
Spectral Reconstruction from RGB Imagery: A Potential Option for Infinite Spectral Data?
Authors: Fsian Abdelhamid , Thomas Jean-Baptiste , Hardeberg Jon , Gouton Pierre
Published: June 2024

Spectral imaging has revolutionisedvarious fields by capturing detailed spatial and spectral information. However, its high cost and complexity limit the acquisition of a large amount of data to generalise processes and methods, thus limiting widespread adoption. To overcome this issue, a body of the literature investigates how to reconstruct spectral information from RGB images, with recent methods reaching a fairly low error of reconstruction, as demonstrated in the recent literature. This article explores the modification of information in the case of RGB-to-spectral reconstruction beyond reconstruction metrics, with a focus on assessing the accuracy of the reconstruction process and its ability to replicate full spectral information. In addition to this, we conduct a colorimetric relighting analysis based on the reconstructed spectra. We investigate the information representation by principal component analysis and demonstrate that, while the reconstruction error of the state-of-the-art reconstruction method is low, the nature of the reconstructed information is different. While it appears that the use in colour imaging comes with very good performance to handle illumination, the distribution of information difference between the measured and estimated spectra suggests that caution should be exercised before generalising the use of this approach.
Medicinal Use of Chicory (Cichorium intybus L.)
Authors: Duda Łukasz , Kłosiński Karol Kamil , Budryn Grażyna , Jaśkiewicz Andrzej , Kołat Damian , Kałuzińska-Kołat Żaneta , Pasieka Zbigniew Włodzimierz
Published: June 2024

The aim of this review is to discuss the numerous health-promoting properties of Cichorium intybus L. and bring together a range of publications to broaden knowledge and encourage further research and consideration of the plant use as treatment for a range of conditions. A comprehensive search of articles in Polish and English from 1986–2022 years was carried out in PubMed, Google Scholar and ScienceDirect using the keywords chicory, Cichorium intybus L., sesquiterpene lactones and their synonyms. Articles were checked for titles, abstracts, and full-text reviews. The first part of the review article discusses chicory, the countries in which it is found, its life cycle or modern cultivation methods, as well as its many uses, which will be discussed in more detail later in the article. The increased interest in plants as medicines or supplements is also briefly mentioned, as well as some limits that are associated with the medical use of plants. In the Results and Discussion section, there is a discussion of the numerous health-promoting properties of Cichorium intybus L. as a whole plant, with its collection of all the components, and we then examine the structure and the individual constituents of Cichorium intybus L. Among these, this article discusses those that can be utilized for causal applications in medicine, including sesquiterpene lactones and polyphenols, mainly known for their anti-cancer properties, although, in this article, their other health-promoting properties are also discussed. The article also examines inulin, a major component of Cichorium intybus L. The Discussion and the Conclusions sections propose directions for more detailed research and the range of factors that may affect specific results, which may have safety implications when used as supplements or medications.
Human Rights and Territories: Academic Perceptions of the 2030 Agenda
Authors: Delgado-Baena Jesús , García-Serrano Juan de Dios , Serrano Laura , Diestre Mejías José Tomás
Published: June 2024

This study is the result of the debate sessions held at the 1st International Conference on Human Rights and Territories at the Pablo de Olavide University in Seville, aimed at analyzing the impact and the agenda itself in the territorial and local contexts. To conduct the research, five focus groups were organized, focusing on the five elements of the agenda: People, Peace, Planet, Prosperity, and Partnerships, with the participation of over 30 international academics, followed by an analysis of the recorded speeches. The results provide a critical epistemic perspective on the 2030 Agenda and its connection with territories, concluding the difficulty of establishing human rights processes in territories from agendas that are centered from the global to the local level.
Introduction to the Special Issue “Rethinking Artful Politics: Bodies of Difference Remaking Body Worlds”
Authors: Changfoot Nadine , Rice Carla , Chandler Eliza
Published: June 2024

“Rethinking Artful Politics: Bodies of Difference Remaking Body Worlds” is a robust Special Issue comprising 11 scholarly articles on the nexus of art and politics [...]
The Evolution of Pure, Bi-Focal and Market-Exposed Social Innovations within Community-Based Systems
Authors: Hrivnák Michal , Moritz Peter
Published: June 2024

Grassroots communities in the 21st century take on the role of social innovators and contribute to addressing market failures and system failures through innovative action. The aim of this empirical study is to evaluate the various modes in which social innovations (products and services) arise in the conditions of community-led grassroots initiatives, to compare the patterns of social and economic value creation through these innovations and to elaborate the possibilities of their commercial exploitation. Drawing from data on 63 innovative products and service of 106 grassroots, taking the optics of grounded theory and adopting the approach of comparative analysis, this study sheds a light on the emergence of “pure”, “bi-focal”, and “market-exposed SI” products and services. Furthermore, the results suggest that it is possible to conceptualize the demand for community-led products and services. The majority of identified innovative products and services of grassroots generate a mix of social and economic outcomes that address both the social needs within one’s own community and needs of various stakeholders, or marginalized groups. The differentiation of SI into “pure”, “bi-focal”, and “market-exposed” was found to be relevant. Also, we identified a rationale for further elaboration of the evolutionary patterns of SI development, as we found that some “pure” SIs have the potential to be introduced to market within the later stages of the SI life-cycle. Some of the investigated products and service had to be commercially exploited due to a paradox—some social, public beneficial solutions need to be commercially exploited to be provided sustainably in the long term.
Sifat Fisikokimia Beras Pecah Kulit dan Beras Sosoh pada Beberapa Varietas
Authors: Suarti Budi
Published: June 2024

Penelitian bertujuan untuk menentukan sifat fisik dan kimia beras pecah kulit (BPK) dan sosoh varietas Ciherang, Mekongga, dan INPARI 32. Analisis terdiri dari warna, proksimat, dan aktivitas antioksidan. Hasil penelitian menunjukkan warna L* dari BPK dan beras sosoh pada varietas INPARI 32 (59,48; 71,84) memiliki tingkat kecerahan tertinggi dibandingkan Ciherang (58,58; 64,91) dan Mekongga (58,41; 61,36). BPK dan beras sosoh pada varietas Ciherang memiliki protein dan lemak yang tertinggi dibandingkan Mekongga dan INPARI 32. BPK Mekongga memiliki antioksidan (0,799 mg/g) lebih tinggi dibandingkan Ciherang (0,713 mg/g) dan INPARI 32 (0,670 mg/g), sedangkan beras setelah penyosohan pada INPARI 32 (0,858 mg/g) memiliki aktivitas antioksidan tertinggi dibandingkan Mekongga (0,622 mg/g) dan Ciherang (0,393 mg/g). Penelitian ini menunjukkan bahwa dari tiga varietas beras, sifat fisik INPARI 32 lebih baik daripada Ciherang dan Mekongga, tetapi dari kandungan zat gizi pada var. Ciherang dan aktivitas antioksidan tertinggi pada var. Mekongga.
Complexul cultural Foeni-Petrești. Analize și comentarii pe marginea stadiului actual al cercetărilor din perspectiva Banatului
Authors:   Institutul de Studii Banatice „Titu Maiorescu”, Academia Română-Filiala Timişoara, Draşovean Florin
Published: June 2024

The article is a variant in Romanian of chapter 4.8 of the monograph of the Foeni-Cimitirul ortodox site, which was published in 2021. Starting from the Eneolithic discoveries from this site, the characteristics of the ceramics from the Banat area are analyzed, as well as their analogies in Transylvania. These were analyzed in correlation with the 14C data and it is concluded that the Foeni Cultural Group is the one that has a contribution to the genesis of the Petreşti Culture.