bluuebunny/crossref_metadata_2025 huggingface dataset:
Dosimetric characteristics of 3D-printed and epoxy-based materials for particle therapy phantoms
Authors: Brunner Jacob , Langgartner Lorenz , Danhel Hannah , Birkfellner Wolfgang , Richter Christian , Wagenaar Dirk , Stock Markus , Georg Dietmar , Knäusl Barbara
Published: May 2024

Objective

3D printing has seen use in many fields of imaging and radiation oncology, but applications in (anthropomorphic) phantoms, especially for particle therapy, are still lacking. The aim of this work was to characterize various available 3D printing methods and epoxy-based materials with the specific goal of identifying suitable tissue surrogates for dosimetry applications in particle therapy.

Methods

3D-printed and epoxy-based mixtures of varying ratios combining epoxy resin, bone meal, and polyethylene powder were scanned in a single-energy computed tomography (CT), a dual-energy CT, and a µCT scanner. Their CT-predicted attenuation was compared to measurements in a 148.2 MeV proton and 284.7 MeV/u carbon ion beam. The sample homogeneity was evaluated in the respective CT images and in the carbon beam, additionally via widening of the Bragg peak. To assess long-term stability attenuation, size and weight measurements were repeated after 6–12 months.

Results

Four 3D-printed materials, acrylonitrile butadiene styrene polylactic acid, fused deposition modeling printed nylon, and selective laser sintering printed nylon, and various ratios of epoxy-based mixtures were found to be suitable tissue surrogates. The materials’ predicted stopping power ratio matched the measured stopping power ratio within 3% for all investigated CT machines and protocols, except for µCT scans employing cone beam CT technology. The heterogeneity of the suitable surrogate samples was adequate, with a maximum Bragg peak width increase of 11.5 ± 2.5%. The repeat measurements showed no signs of degradation after 6–12 months.

Conclusion

We identified surrogates for soft tissue and low- to medium-density bone among the investigated materials. This allows low-cost, adaptable phantoms to be built for quality assurance and end-to-end tests for particle therapy.
Tibetans exhibit lower hemoglobin concentration and decreased heart response to hypoxia during poikilocapnia at intermediate altitude relative to Han Chinese
Authors: Moya E. A. , Yu J. J. , Brown S. , Gu W. , Lawrence E. S. , Carlson R. , Brandes A. , Wegeng W. , Amann K. , McIntosh S. E. , Powell F. L. , Simonson T. S.
Published: May 2024

Background

High-altitude populations exhibit distinct cellular, respiratory, and cardiovascular phenotypes, some of which provide adaptive advantages to hypoxic conditions compared to populations with sea-level ancestry. Studies performed in populations with a history of high-altitude residence, such as Tibetans, support the idea that many of these phenotypes may be shaped by genomic features that have been positively selected for throughout generations. We hypothesize that such traits observed in Tibetans at high altitude also occur in Tibetans living at intermediate altitude, even in the absence of severe sustained hypoxia.

Methodology

We studied individuals of high-altitude ancestry (Tibetans, n = 17 females; n = 12 males) and sea-level ancestry (Han Chinese, n = 6 females; n = 10 males), both who had been living at ∼1300 m (∼4327 ft) for at least 18 months. We measured hemoglobin concentration ([Hb]), hypoxic ventilatory response (HVR), and hypoxic heart rate response (HHRR) with end-tidal CO2 (PetCO2) held constant (isocapnia) or allowed to decrease with hypoxic hyperventilation (poikilocapnia). We also quantified the contribution of CO2 on ventilation and heart rate by calculating the differences of isocapnic versus poikilocapnic hypoxic conditions (Δ V˙I/ΔPetCO2 and ΔHR/ΔPetCO2, respectively).

Results

Male Tibetans had lower [Hb] compared to Han Chinese males (p < 0.05), consistent with reports for individuals from these populations living at high altitude and sea level. Measurements of ventilation (resting ventilation, HVR, and PetCO2) were similar for both groups. Heart rate responses to hypoxia were similar in both groups during isocapnia; however, HHRR in poikilocapnia was reduced in the Tibetan group (p < 0.03), and the heart rate response to CO2 in hypoxia was lower in Tibetans relative to Han Chinese (p < 0.01).

Conclusion

These results suggest that Tibetans living at intermediate altitude have blunted cardiac responses in the context of hypoxia. Hence, only some of the phenotypes observed in Tibetans living at high altitude are observed in Tibetans living at intermediate altitude. Whereas blunted cardiac responses to hypoxia is revealed at intermediate altitudes, manifestation of other physiological adaptations to high altitude may require exposure to more severe levels of hypoxia.
On the advantages and disadvantages of choice: future research directions in choice overload and its moderators
Authors: Misuraca Raffaella , Nixon Ashley E. , Miceli Silvana , Di Stefano Giovanni , Scaffidi Abbate Costanza
Published: May 2024

Researchers investigating the psychological effects of choice have provided extensive empirical evidence that having choice comes with many advantages, including better performance, more motivation, and greater life satisfaction and disadvantages, such as avoidance of decisions and regret. When the decision task difficulty exceeds the natural cognitive resources of human mind, the possibility to choose becomes more a source of unhappiness and dissatisfaction than an opportunity for a greater well-being, a phenomenon referred to as choice overload. More recently, internal and external moderators that impact when choice overload occurs have been identified. This paper reviews seminal research on the advantages and disadvantages of choice and provides a systematic qualitative review of the research examining moderators of choice overload, laying out multiple critical paths forward for needed research in this area. We organize this literature review using two categories of moderators: the choice environment or context of the decision as well as the decision-maker characteristics.
Prevention regulatory focus, desired cultural tightness, civic moral disengagement, and emotional reactions to normative daily transgressions: a serial mediation model among adults in Italy
Authors: Baldner Conrad , Pierro Antonio
Published: May 2024

Why do people have positive or indifferent reactions to norm violations? The present research hypothesized that individuals who focus on the avoidance of negative outcomes, for example punishments for rule violations, (i.e., a prevention focus) are hypothesized to also have a desire for rigid and clear norms (i.e., desired cultural tightness) as well as punishments for norm violations. Such norms and punishments narrow accepted behavior and, if clearly communicated, can limit rule violations. Consequently, individuals who desire higher levels of cultural tightness should be less likely to justify poor citizenship behavior (i.e., civic moral disengagement) as this behavior is antithetical to desired cultural tightness. Finally, such individuals should also be more likely to react negatively to norm violations. Data for the present study was conducted in Italy. A total of 1,181 participants were included in the analysis; participation requirements were that they be adults who were residents of Italy. Participants completed self-report measures of the prevention focus, desired cultural tightness, civic moral disengagement, and reactions to general norm violations (e.g., exceeding the speed limit, vandalism). The hypothesized serial mediation model was supported. This model can help explain why individuals can fail to react to “everyday” norm violations, as well societal-level violations (e.g., failing to respect hygienic standards during the COVID pandemic). It also calls on the need to develop mass communication approaches that can influence individuals’ prevention focus on a large scale, as this can have downstream effects of reactions to such violations.
Psychometric properties of the Quiet Ego Scale (iQES) within the Italian cultural context
Authors: Bernabei Laura , Silvestrini Cristiana , Grimaldi Lucrezia Andrea , Piserchia Valentina , Riggio Francesco , Marino Giovanni , Valente Donatella , Pompili Enrico
Published: May 2024

Introduction

The quiet ego indicates a more compassionate conception of self-identity that integrates others into the self by lowering the intensity of the ego and enhancing the awareness of the present moment. The Quiet Ego Scale (QES) is a 14-item self-report measure of quiet ego, and it is composed of the following four psychological domains: detached awareness, inclusive identity, perspective taking, and growth. The present study aimed to test the psychometric properties of the Quiet Ego Scale within the Italian cultural context (iQES).

Methods

A total of 160 Italian university students aged between 20 and 42 years, with a mean age of 22.85 years (SD = 3.41), completed the measures of the iQES and of other psychological dimensions. The psychometrics properties of iQES were assessed based on its internal consistency, test-retest reliability, and construct validity through comparisons with other correlated psychological measures.

Results

Analyses confirmed the psychometrics properties of iQES. As in previous studies, the quiet ego was positively associated with the indicators of resilience (p < 0.01), happiness (p < 0.05), self-esteem (p < 0.01), and psychological wellbeing (p < 0.01).

Discussion

The study discussed the possible uses of the iQES in the field of mental health, specifically focusing on improving adherence to psychological therapies and enhancing psychological and social well-being. The results indicated strong psychometric properties of the iQES in measuring the quiet ego construct. Our findings enrich the literature on the validity of the iQES and highlight the multidimensional nature of the quiet ego construct.
The effect of conscious mindfulness-based informative approaches on managing symptoms in hemodialysis patients
Authors: Akbulut Gönül , Erci Behice
Published: May 2024

Introduction

The research was conducted to determine the effect of conscious mindfulness based informative approaches applied in hemodialysis patients on reducing stress and managing symptoms.

Methods

This research was conducted as a real experimental model with a control group. Research population consisted of 160 hemodialysis patients. The sample of the study was determined as 120 hemodialysis patients in total, 60 in the experimental and 60 in the control group, as a result of the power analysis. After the pre-test application, a mindfulness-based stress reduction program was applied to the experimental group. In the analysis of the data collected in the research, percentage, frequency, chi-square analysis, t-test for independent groups, t-test for dependent groups were used by means of SPSS for Windows 22.00 statistical software package.

Results

The t-test analyses of the differences between pre-test and post-test scores of hemodialysis patients in the experimental group were found to be significant in favor of the post-tests.

Discussion

It was found out that the conscious mindfulness-based informative approaches decreased the perceived stress and anxiety of the patients in the experimental group, whereas increased their levels of conscious mindfulness and symptom management.
On Chinese learning strategies of learners from Central Asian countries: an analysis of gender, age, and learning duration effects
Authors: Chen Ruiling , Zhang Lirui
Published: May 2024

This research focuses on the Chinese learning strategies employed by learners from Central Asian countries, specifically examining the effects of gender, age, and learning duration. The study aims to identify and analyze the demographic factors that influence the learning approaches of these learners, providing insights for more effective teaching and learning of Chinese as a foreign language. Data are collected through questionnaires and interviews, and statistical analysis is conducted to explore the correlations between gender, age, learning duration, and learning strategies. The learning strategy model adopted in this study provides a comprehensive classification of language learning strategies. The results underscore the significance of incorporating these factors into language education programs, providing valuable insights into the unique needs and challenges encountered by learners from Central Asian countries. The findings indicate that students from Central Asian countries predominantly utilize social strategies, metacognitive strategies, and affective strategies in their Chinese language learning. These are followed by compensatory strategies, cognitive strategies, and memory strategies. While gender does not exert a significant impact on the utilization of Chinese learning strategies, there are discernible variations in memory and affective strategies between males and females. Age does not significantly affect overall learning strategies, but there are notable disparities in compensatory strategies among different age groups. Learning duration has a significant effect on compensation and metacognitive strategies. The correlation between learning duration and overall strategies is significant indicating that learners with different learning durations exhibit notable differences in compensation and metacognitive strategies.
Significance loss brings to extreme self-care related behaviors: the role of interpersonal influence and obsessive (vs. harmonious) passion
Authors: Contu Federico , Pierro Antonio
Published: May 2024

Building on Significance Quest Theory we hypothesized that significance loss feelings can bring people to extreme self-care related behaviors via (a) the susceptibility to interpersonal influence, and (b) the development of a predominance of obsessive (vs. harmonious) passion toward the self-care. To test these hypotheses, we ran one cross-sectional study among voluntary participants (N = 401). Results confirmed our hypotheses, suggesting that physical appearance is perceived as a fruitful and useful route to maintain or even restoring ones’ personal sense of significance. Notably, these results shed light on another scope that can be exploited to achieve social significance (i.e., physical appearance) through extremism, and could represent a starting point to design practical intervention to reduce the examined extreme behaviors.
Profiles of executive functions in middle childhood and prediction of later self-regulation
Authors: Brandt Ariadne , Bondü Rebecca , Elsner Birgit
Published: May 2024

Most research on the development of executive functions (EF) has applied variable-oriented approaches, neglecting the potential inter- and intraindividual interplay of these capacities. In a person-oriented approach, the present study identified varying profiles of performance for three cool EF facets: inhibition, working-memory updating, and cognitive flexibility, as well as two hot EF facets: affective decision-making and delay of gratification, in a community sample of 1,657 children (T1; age: 6–11 years, M = 8.36 years, 52.1% female) via latent profile analysis. The best-fitting model allowed for partial dependence across the three cool EF and included four profiles: all-average (69.4% of the children), low-delay (19.0%), regulated-decision-making (7.0%), and low-inhibition (4.6%). Age, binary sex, socio-economic status, multilingualism, and processing speed were identified as significant characteristics of EF profile membership. Longitudinally, a higher probability of belonging to the low-inhibition profile predicted lower rates of the self-regulatory outcome of inhibitory control 1 year later, while belonging to the regulated-decision-making profile predicted lower rates of the ability to plan and organize 3 years later. These results not only demonstrate the existence of subgroups with different concurrent within-person expressions of EF performance, but also identify related characteristics and longitudinal outcomes of subgroup membership. In turn, these conclusions stress the importance of person-oriented research to inform on differing weaknesses or strengths in EF performance for varying individuals, thereby providing valuable insight for educational and clinical research into the design of effective personalized support or interventions during middle childhood.
Latent profile analysis of Eysenck’s personality dimensions and psychological constructs in university students
Authors: Pan Lin-Ling , Zhou Si-Ran , Chen Guan-Zhao , Ke Yue-Dan , Huang Zi-Ye , Wu Yu-Wei , Yan Wen-Jing
Published: May 2024

Background

The exploration of personality traits in relation to psychological constructs has become increasingly relevant in understanding the mental health of university students (the emerging adulthood). Studies have focused on how dimensions intersect with various psychological parameters.

Aim

The study aims to identify distinct personality profiles among university students based on Eysenck’s personality dimensions and investigate how these profiles differ across psychological constructs.

Method

A quantitative methodology was utilized, involving 708 university students from Wenzhou and Nanjing in China as participants. The research employed the Eysenck Personality Questionnaire along with other psychological measures. Latent Profile Analysis was applied to categorize the participants into distinct personality profiles.

Results

Four distinct personality profiles emerged: ‘The Reserved Analyst,’ ‘The Social Diplomat,’ ‘The Unconventional Pragmatist,’ and ‘The Impulsive Truth-Teller.’ Significant differences were found among these profiles on various psychological constructs. ‘The Social Diplomat’ exhibited the most adaptive psychological profile, with higher cognitive reappraisal (F = 45.818, p < 0.001, η2 = 0.163), meaning in life (F  = 17.764, p < 0.001, η2 = 0.070), and positive coping (F = 40.765, p < 0.001, η2 = 0.148) compared to other profiles. Conversely, ‘The Reserved Analyst’ showed higher intolerance of uncertainty (F = 13.854, p  < 0.001, η2 = 0.056) and state anxiety (F = 26.279, p  < 0.001, η2 = 0.101).

Conclusion

This study enriches the understanding of personality traits in relation to psychological constructs within the context of university student populations. By identifying distinct personality profiles, it lays the groundwork for developing tailored mental health strategies that cater to the specific needs of different student groups.
Language transfer in L2 academic writings: a dependency grammar approach
Authors: Bi Yude , Tan Hua
Published: May 2024

Dependency distance (DD) is an important factor in language processing and can affect the ease with which a sentence is understood. Previous studies have investigated the role of DD in L2 writing, but little is known about how the native language influences DD in L2 academic writing. This study is probably the first one that investigates, though a large dataset of over 400 million words, whether the native language of L2 writers influences the DD in their academic writings. Using a dataset of over 2.2 million abstracts of articles downloaded from Scopus in the fields of Arts & Humanities and Social Sciences, the study analyzes the DD patterns, parsed by the latest version of the syntactic parser Stanford Corenlp 4.5.5, in the academic writing of L2 learners from different language backgrounds. It is found that native languages influence the DD of English L2 academic writings. When the mean dependency distance (MDD) of native languages is much longer than that of native English, the MDD of their English L2 academic writings will be much longer than that of English native academic writings. The findings of this study will deepen our insights into the influence of native language transfer on L2 academic writing, potentially shaping pedagogical strategies in L2 academic writing education.
Patients, healthcare providers, and general population preferences for hemodialysis vascular access: a discrete choice experiment
Authors: Wong Tak-Sui , Chen Qian , Liu Taoran , Yu Jing , Gao Yangyang , He Yan , Zhong Qiongqiong , Tan Zijian , Liu Tinlun , Lu Jian , Huang Jian , Zhang Casper J. P. , Yin Lianghong , Hu Bo , Ming Wai-Kit
Published: May 2024

Background

A patient-centered dialysis treatment option requires an understanding of patient preferences for alternative vascular accesses and nephrologists often face difficulties when recommending vascular access to end-stage kidney disease (ESKD) patients. We aimed to quantify the relative importance of various vascular access characteristics to patients, healthcare providers and general population, and how they affect acceptability for patients and healthcare providers.

Methods

In a discrete choice experiment, patients with maintenance hemodialysis (MHD), healthcare providers, and individuals from the general population were invited to respond to a series of hypothetical vascular access scenarios that differed in five attributes: cumulative patency, infection rate, thrombosis rate, cost, and time to maturation. We estimated the respondents’ preference heterogeneity and relative importance of the attributes with a mixed logit model (MXL) and predicted the willingness to pay (WTP) of respondents via a multinomial logit model (MNL).

Results

Healthcare providers (n = 316) and the general population (n = 268) exhibited a favorable inclination toward longer cumulative patency, lower access infection rate and lower access thrombosis rate. In contrast, the patients (n = 253) showed a preference for a 3-year cumulative patency, 8% access infection rate, 35% access thrombosis rate and 1.5 access maturity time, with only the 3-year cumulative patency reaching statistical significance. Among the three respondent groups, the general population found cumulative patency less important than healthcare providers and patients did. Patients demonstrated the highest WTP for cumulative patency, indicating a willingness to pay an extra RMB$24,720(US$3,708) for each additional year of patency time.

Conclusion

Patients and healthcare providers had a strong preference for vascular access with superior patency. While the general population preferred vascular access with lower thrombosis rates. These results indicate that most patients prefer autogenous arteriovenous fistula (AVF) as an appropriate choice for vascular access due to its superior patency and lower complications than other vascular access types.
Characterizing health-related quality of life and identifying disease predictors among patients suspected of having long COVID: an analysis of COMET-ICE clinical trial data
Authors: Gelhorn Heather L. , Ghafoori Parima , Cutts Katelyn , Birch Helen , Savva Yulia , Satram Sacha , Lloyd Emily , Chen Wen-Hung
Published: May 2024

Introduction

Long COVID affects health-related quality of life (HRQoL). Here, we investigate the extent to which symptoms experienced during the acute phase of COVID-19 are significant predictors of the presence of long COVID at 12 weeks.

Methods

Post-hoc analysis of COMET-ICE trial data, which assessed sotrovimab vs. placebo for treatment of mild-to-moderate COVID-19 among high-risk patients. Patient-reported outcome measures were completed during the trial, including the inFLUenza Patient-Reported Outcome Plus (FLU-PRO Plus), the 12-Item Short Form (SF-12) Hybrid questionnaire, and the Work Productivity and Activity Impairment Questionnaire: General Health (WPAI:GH). COVID-19 symptoms and impacts (measured by the FLU-PRO Plus) and HRQoL (measured by SF-12 Hybrid and WPAI:GH) were compared between the acute phase (Days 1–21 and 29) and long-COVID phase (at Week 12) among patients with and without long COVID based on COMET-ICE data. Subgroups experiencing long COVID were derived using “All,” “Returning,” and “Persisting” symptomatic definitions. Long-COVID predictors were identified using a multivariate logistic regression model; odds ratios (ORs) and 95% CIs were calculated.

Results

Long-COVID subgroups had significantly higher baseline scores for most FLU-PRO Plus domains and Total Score compared with the non-long-COVID group. WPAI:GH and SF-12 Hybrid scores generally showed significantly more impairment for the long-COVID subgroups at baseline and Week 12 vs. the non-long-COVID group. In the univariate analyses, all FLU-PRO Plus domains were significant predictors of long COVID (all p < 0.05), with the exception of the Sense domain. Older age increased the risk of long COVID (OR 1.02, 95% CI 1.00–1.04, p < 0.05). Non-White patients were significantly less likely to have long COVID by the Returning and Persisting definitions vs. White patients (all p < 0.05). In the multivariate analysis, higher scores for the Nose domain (ORs 3.39–5.60, all p < 0.01) and having COPD (ORs 3.75–6.34, all p < 0.05) were significant long-COVID predictors.

Conclusion

Patients who progressed to long COVID had higher symptom severity during the acute disease phase and showed significantly greater negative impact on HRQoL over an extended time period from initial infection through at least the subsequent 3 months. The FLU-PRO Plus Nose domain and having COPD were significant predictors of long COVID.
A novel multivariate logistic model for predicting risk factors of failed treatment with carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia
Authors: Sun Ke , Peng Fangchen , Xu Kaiqiang , Liu Yong , Zhou Xuanping , Shang Nan , Li Chao
Published: May 2024

Background

This study aimed to explore the risk factors for failed treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia (CRAB-VAP) with tigecycline and to establish a predictive model to predict the incidence of failed treatment and the prognosis of CRAB-VAP.

Methods

A total of 189 CRAB-VAP patients were included in the safety analysis set from two Grade 3 A national-level hospitals between 1 January 2022 and 31 December 2022. The risk factors for failed treatment with CRAB-VAP were identified using univariate analysis, multivariate logistic analysis, and an independent nomogram to show the results.

Results

Of the 189 patients, 106 (56.1%) patients were in the successful treatment group, and 83 (43.9%) patients were in the failed treatment group. The multivariate logistic model analysis showed that age (OR = 1.04, 95% CI: 1.02, 1.07, p = 0.001), yes. of hypoproteinemia (OR = 2.43, 95% CI: 1.20, 4.90, p = 0.013), the daily dose of 200 mg (OR = 2.31, 95% CI: 1.07, 5.00, p = 0.034), yes. of medication within 14 days prior to surgical intervention (OR = 2.98, 95% CI: 1.19, 7.44, p = 0.019), and no. of microbial clearance (OR = 0.31, 95% CI: 0.14, 0.70, p = 0.005) were risk factors for the failure of tigecycline treatment. Receiver operating characteristic (ROC) analysis showed that the AUC area of the prediction model was 0.745 (0.675–0.815), and the decision curve analysis (DCA) showed that the model was effective in clinical practice.

Conclusion

Age, hypoproteinemia, daily dose, medication within 14 days prior to surgical intervention, and microbial clearance are all significant risk factors for failed treatment with CRAB-VAP, with the nomogram model indicating that high age was the most important factor. Because the failure rate of CRAB-VAP treatment with tigecycline was high, this prediction model can help doctors correct or avoid risk factors during clinical treatment.
Comparison of physical activity and physical fitness in children and adolescents of Chinese Han and Tibet ethnicity
Authors: Liu Xiaodi , Tang Jiaxing , Long Weixuan , Zou Yu , Tan Jingwang
Published: May 2024

Background

Physical activity (PA) and physical fitness (PF) are important markers of health status in children and adolescents in different ethnicities. In this study, we aimed to compare the PA and PF indicators between Tibetan and Han children and adolescents.

Methods

Children and adolescents of 4–9 grades were recruited in Shigatse (n = 963) and Shanghai (n = 2,525) respectively. The information related to demographic, PA, and PF was collected via a self-reported questionnaire. PA was assessed through the participation of moderate to vigorous PA (MVPA), muscle-strengthening exercise (MSE) and organized sport participation (OSP). PF was estimated using the International Fitness Scale containing components of overall fitness, cardiorespiratory fitness, speed and agility, muscular strength and flexibility.

Results

Han (mean age = 13.45 ± 3.3 years; 49.7% girls) and Tibet (mean age = 13.8 ± 2.5 years; 48.3% girls) children and adolescents from Shanghai and Shigatse completed the questionnaire survey. It was revealed that Tibetan students had higher MVPA, MSE and OSP than children and adolescents of Han ethnicity (p < 0.01, small to medium effect size). A relatively higher percentage of student in Shanghai did not participate in any form of PA. On the other hand, less Tibetan students thought their PF indicators including overall fitness, cardiorespiratory fitness, speed and agility, muscular strength and flexibility were poor or very poor than their counterparts of Han ethnicity (p < 0.01, small to medium effect size).

Conclusion

Tibetan children and adolescents have higher levels of PA and PF in comparison to their Han counterparts. More children and adolescents of Han ethnicity engage in no PA and think their PF indicators were poor.
An examination from 1990 to 2019: investigating the burden of knee dislocation on a global scale
Authors: Chen Cheng , Li Bing , Zhou Haichao , Ye Tianbao , Yang Yunfeng
Published: May 2024

Background

The literature on the disease burden of knee dislocation is lacking. The aim of the study is to systematically assess the global burden, trends, causes, and influencing factors of knee dislocation.

Methods

The incidence and years lived with disability (YLDs) of knee dislocation were assessed globally, as well as at the regional and national levels from 1990 to 2019. Subsequent analyses focused on the age and gender distribution related to knee dislocation. An investigation into the main causes of knee dislocation followed. Finally, the Pearson correlation between age-standardized rates and social-demographic index (SDI) was calculated.

Results

Although the age-standardized incidence and YLDs rate of knee dislocation decreased over the past 30 years, the incidence and YLDs number increased. The disease burden remained higher in males compared to females. Males and females showed different patterns of incidence rates in each age group, but their YLDs rates were similar. Over the past 30 years, the disease burden of knee dislocation increased in the older population while declining in the younger population. Falls had consistently emerged as the most important cause for both incidence and YLD rates. Additionally, a positive correlation between SDI and the disease burden of knee dislocation was found.

Conclusion

The disease burden of knee dislocation remains heavy. It is essential to recognize the evolving epidemiology of knee dislocation. Utilizing data-driven assessments can assist in formulating public health policies and strategies to improve overall well-being.
Multi-dimensional impact of COVID-19 on active mobility in urban China: a scoping review of empirical knowledge
Authors: Du Shengchen , Tan Hongze , Gao Hua
Published: May 2024

Active mobility, such as cycling and walking, is assuming a growing significance in the daily lives of urban residents in China due to its positive impact on health and the environment. The impact of the COVID-19 epidemic has elicited significant changes in behaviors, perceptions, and intellectual viewpoints in this domain, potentially altering residents’ physical activities in the long-term. This scoping review seeks to delve into the multi-dimensional influence of the epidemic on active mobility in urban China. A thorough investigation of English and Chinese studies up to January 2024 was conducted, drawing from articles in Web of Science and the Chinese National Knowledge Infrastructure. Only empirical studies providing knowledge into this subject were selected in the review, which comprised 20 studies in total. This review indicates that the influence of COVID-19 on active urban mobility in China has exhibited contradictory outcomes in terms of behavior. Besides, the experiences during the epidemic have significantly shaped citizens’ attitudes and understanding of active mobility. The repercussions of the epidemic and the ensuing restrictions exacerbate the existing challenges faced by women, particularly those who are married, the older adult, and individuals with low incomes. The results exhibit both resemblances and idiosyncrasies when juxtaposed with prior research conducted in different nations. This analysis also offers valuable insights for improving active mobility across individual, organizational, and socio-political realms. The current state of empirical understanding in this field underscores the need for further research endeavors employing diverse methodological approaches and increased emphasis on the transformations anticipated in the post-epidemic era.
Game changer—talent transfer pathways in sport: a systematic review
Authors: Green Adeline , Fleischman David , Mulcahy Rory , Kean Bridie
Published: May 2024

Research question

Talent transfer, an accelerated sport pathway to expertise, holds considerable appeal for sports organisations. As an emerging area of academic research across a range of sport disciplines, there is opportunity for to advance knowledge and practice. This review aimed to (a) explore how talent transfer has been defined, to develop a synthesised definition; (b) systematically identify the factors that influence talent transfer; and (c) investigate how theory underpins and enhances understanding of talent transfer.

Research methods

A systematic review was conducted of 12 peer-reviewed journal articles on talent transfer using the PRISMA approach.

Results and findings

Aiming for a comprehensive, multidisciplinary perspective, the results: introduce a clear, synthesised conceptualisation of talent transfer as an accelerated sport pathway in which a highly trained athlete in one sport (donor sport), transitions to a new sport (recipient sport) with the potential of achieving high-performance success; systematically map influencing factors; and outline considered theories. Factors influencing talent transfer span individual, task-related, and environmental constraints. The review exposes a scarcity of theoretical foundation in current research, suggesting ecological dynamics as a promising approach to advance research and practice.

Implications

Practical and theoretical implications arise, emphasising the usefulness of a synthesised definition and a multifactorial approach for designing, implementing, evaluating, and researching talent transfer pathways. This benefits sports administrators, managers, and researchers.
Can fiscal expenditure for agriculture mitigate the impact of climate change on agricultural production?
Authors: Hao Wang , Yang Jianqing , Hu Xiangdong , Zhang Zhenxing , Shi Zizhong , Zhou Hui
Published: May 2024

The profound impact of climate change on agricultural production, and the government’s fiscal expenditure for agriculture, is considered a crucial means to address this challenge. This study utilizes panel data from all prefecture-level cities in Heilongjiang Province from 2000 to 2020. Drawing upon the Cobb–Douglas production function, an economic climate model is constructed to empirically analyze the impact of climate change on grain yield in Heilongjiang Province. Furthermore, the role of fiscal expenditure for agriculture in mitigating the effects of climate change on grain yield is explored. Feasible Generalized Least Squares (FGLS) estimation is employed to address issues of “heteroscedasticity,” “autocorrelation within groups,” and “cross-sectional contemporaneous correlation” present in the model. The results indicate that climate change has a positive impact on rice and corn yields, while exhibiting a negative impact on wheat yield. The influence of climate change on crop yield is both linear and nonlinear. Specifically, temperature demonstrates a linear relationship with rice and corn yields, whereas precipitation shows a significant inverted U-shaped relationship with rice and corn yields. The impact of climate change on grain production in Heilongjiang Province varies significantly across regions. Fiscal expenditure for agriculture has a significant positive effect on the yield of major grain crops in Heilongjiang Province. In addressing the impact of climate change on grain production, agricultural fiscal expenditure enhances the positive effect of precipitation on rice and corn yields, while diminishing the positive impact of temperature on corn yield.
Perspective: could Ethiopian potatoes contribute to environmental sustainability, the Ethiopian economy, and human health?
Authors: Yimam Mohammed Ahmed , Andreini Martina , Carnevale Sara , Muscaritoli Maurizio
Published: May 2024

Environmental data are rapidly accruing on the unsustainability of diets based on animal products, such as dairy and meats. Shifting to alternative sources of protein is inevitable given an increase in the projected global population and protein demand. Left unchecked, a collision between food security and sustainability is imminent. Potatoes could be the strategic food and cash crop to harmonize food security and sustainability worldwide. Recently, there has been a growing interest in extracting proteins from the byproduct of the potato starch industry known as potato fruit juice. These proteins are garnering attention due to their nutritional value, characterized by a well-balanced amino acid profile, as well as their functional properties including emulsifying, foaming, and gelling capabilities. Moreover, these proteins are considered to be less allergenic than some other protein sources. Extracting potato protein, which is sourced as a byproduct, reduces food loss and waste, thereby eliminating pathogenic microorganisms from the environment and mitigating greenhouse gas emissions. Ethiopia is a major potato producer in East Africa. Potatoes help the country increase household income, ensure food security and revenue generation, and produce starch. However, Ethiopia’s potato starch industry has not yet begun protein extraction, despite the vital role of the proteins and the country’s huge cultivation potential. Furthermore, the global potato protein market is experiencing significant growth. This information urgently calls for innovative approaches to assess the impact of extracting protein from potatoes produced in Ethiopia. Therefore, this perspective article has two main objectives. First, to scan the extent of potato production in Ethiopia in relation to environmental sustainability and the economy. Second, to provide prospects on the impact of extracting protein isolate from potatoes produced in Ethiopia on environmental sustainability, Ethiopia’s economy, and human health.
Benefits of dexmedetomidine during noninvasive mechanical ventilation in major abdominal surgery patients with postoperative respiratory failure
Authors: Yildirim Fatma , Karaman Irem , Yıldırım Mehmet , Karabacak Harun
Published: May 2024

Objective

The efficacy of non-invasive mechanical ventilation (NIMV) on the postoperative ARF is conflicting and the failure rate of NIMV in this patient population is high. In our study, we hypothesized that the use of dexmedetomidine during NIMV in major abdominal surgical patients can reduce NIMV failure without significant side affect.

Methods

Medical records of patients who underwent major abdominal surgery, admitted to our general surgery intensive care unit (ICU), developed postoperative ARF, received NIMV (with oro-nasal mask) and dexmedetomidine infusion were enrolled in this study. The infusion rate was adjusted to maintain a target sedation level of a Richmond Agitation-Sedation Scale (RASS) (−2)–(−3). The sedation was stopped when NIMV was discontinued.

Results

A total of 60 patients, 42 (70.0%) male, and 18 (30.0%) female, with a mean age of 68 ± 11 years were included in the study. The mean APACHE II score was 20 ± 6. Dexmedetomidine was infused for a median of 25 h (loading dose of 0.2 mcg/kg for 10 min, maintained at 0.2–0.7 mcg/kg/h, titrated every 30 min). RASS score of all study group significantly improved at the 2 h of dexmedetomidine initiation (+3 vs. −2, p = 0.01). A targeted sedation level was achieved in 92.5% of patients. Six (10.0%) patients developed bradycardia and 5 (8.3%) patients had hypotension. The mean NIMV application time was 23.4 ± 6.1 h. Seven (11.6%) patients experienced NIMV failure, all due to worsening pulmonary conditions, and required intubation and invasive ventilation. Fifty-three (88.3%) patients were successfully weaned from NIMV with dexmedetomidine sedation and discharged from ICU. The duration of NIMV application and ICU stay was shorter in NIMV succeded group (21.4 ± 3.2 vs. 29.9 ± 6.4; p = 0.012).

Conclusion

Our study suggests that dexmedetomidine demonstrates effective sedation in patients with postoperative ARF during NIMV application after abdominal surgery. Dexmedetomidine can be considered safe and capable of improving NIMV success.
Asystole in a young child with tetrahydrocannabinol overdose: a case report and review of literature
Authors: Masilamani Mats Steffi Jennifer , Leff Rebecca , Kawai Yu
Published: May 2024

Introduction

The association between Δ8-tetrahydrocannabinol (THC) and cardiac dysrhythmia has not been well described in children. Asystole, while consistent with reports of severe bradycardia and apnea in children, is uncommonly described in the current literature. We present the first pediatric case of asystole and apnea following THC ingestion.

Case

A 7-year-old male presented to the emergency department (ED) after his mother noticed he was lethargic 3–4 h after accidental ingestion of five 15 mg (total of 75 mg) Δ8-THC gummies. Upon arrival, he was vitally stable and well-appearing. He received maintenance intravenous fluids. Approximately 7 h after initial ingestion, he experienced a >15-s episode of asystole and apnea on telemetry requiring sternal rub to awaken. This was followed by bradycardia (60 beats per minute range) which resolved with 0.1 mg glycopyrrolate. He was admitted to the PICU, drowsy but arousable with stable vitals. After an uneventful 24-h (post-ingestion) PICU observation, he was discharged home in stable condition.

Discussion

To our knowledge, this is the first reported pediatric case of THC-induced asystole. The etiology of asystole may be attributed to direct vagal stimulation of THC or respiratory depression. The typical recommended observation time after potential toxicity is 3–6 h after children have returned to their physiological and behavioral baseline. Our patient was clinically stable with no concern for respiratory depression or cardiac dysrhythmia yet experienced an asystolic pause with apnea 7 h after initial ingestion.

Conclusion

Our case demonstrates that asystole and apnea may occur in pediatric patients following large THC ingestions and those symptoms can appear late outside of the currently recommended observation period.
Unrevealing the therapeutic potential of artesunate against emerging zoonotic Babesia microti infection in the murine model
Authors: Fazilani Saqib Ali , An Wei , Li Sihong , Hassan Mohammad Farooque , Ishfaq Muhammad , Lakho Shakeel Ahmed , Farooque Muhammad , Shoaib Muhammad , Zhang Xiuying
Published: May 2024

Babesiosis, a zoonotic blood protozoal disease, threatens humans and animals and is difficult to treat due to growing antimicrobial resistance. The study aimed to investigate the therapeutic efficacy of artesunate (AS), a well-known derivative of artemisinin, against Babesia microti (B. microti) using a murine infection model. Male BALB/c mice (6 weeks old; 15 per group) were chosen and randomly divided into 1) the control group, 2) the B. microti group, and 3) the B. microti + artesunate treatment groups. AS treatment at 2 mg/kg, 4 mg/kg, and 8 mg/kg of body weight significantly (p < 0.05) reduced the B. microti load in blood smears in a dose-dependent manner. Additionally, AS treatment mitigated the decrease in body weight and restored the normal state of the liver and spleen viscera index compared to the B. microti-infected group after 28 days. Hematological analysis revealed significant increases in RBC, WBC, and PLT counts post-AS treatment compared to the B. microti-infected group. Furthermore, AS administration resulted in significant reductions in total protein, bilirubin, ALT, AST, and ALP levels, along with reduced liver and spleen inflammation and lesions as observed through histopathological analysis. AS also elicited dose-dependent changes in mRNA and protein expression levels of apoptotic, proinflammatory, and anti-inflammatory cytokines in the liver compared to the control and B. microti-infected groups. Immunolabeling revealed decreased expression of apoptotic and inflammation-related proteins in AS-treated hepatic cytoplasm compared to the B. microti-infected group. AS also in dose-dependent manner decreased apoptotic protein and increased Bcl-2. Overall, these findings underscore the potential of AS as an anti-parasitic candidate in combating B. microti pathogenesis in an in vivo infection model, suggesting its promise for clinical trials as a treatment for babesiosis.
Modulation of the rat intestinal microbiota in the course of Anisakis pegreffii infection
Authors: Zeng Min-hao , Li Shan , Lv Qing-bo , Wang Xiao-xu , Qadeer Abdul , Mahmoud Mohamed H.
Published: May 2024

Background

Anisakis are globally distributed, marine parasitic nematodes that can cause human health problems, including symptoms such as vomiting, acute diarrhea, and allergic reactions. As parasitic nematodes that primarily affect the patient’s digestive tract, intestinal helminths can interact directly with the host microbiota through physical contact, chemicals, or nutrient competition. It is widely accepted that the host microbiota plays a crucial role in the regulation of immunity.

Materials and methods

Nematodes collected from the abdominal cavity of marine fish were identified by molecular biology and live worms were artificially infected in rats. Infection was determined by indirect ELISA based on rat serum and worm extraction. Feces were collected for 16S rDNA-based analysis of microbiota diversity.

Results

Molecular biology identification based on ITS sequences identified the collected nematodes as A. pegreffii. The success of the artificial infection was determined by indirect ELISA based on serum and worm extraction from artificially infected rats. Microbiota diversity analysis showed that a total of 773 ASVs were generated, and PCoA showed that the infected group was differentiated from the control group. The control group contained five characterized genera (Prevotellaceae NK3B31 group, Turicibacter, Clostridium sensu stricto 1, Candidatus Stoquefichus, Lachnospira) and the infected group contained nine characterized genera (Rodentibacter, Christensenella, Dubosiella, Streptococcus, Anaeroplasma, Lactococcus, Papillibacter, Desulfovibrio, Roseburia). Based on the Wilcoxon test, four processes were found to be significant: bacterial secretion system, bacterial invasion of epithelial cells, bacterial chemotaxis, and ABC transporters.

Conclusion

This study is the first to analyze the diversity of the intestinal microbiota of rats infected with A. pegreffii and to determine the damage and regulation of metabolism and immunity caused by the infection in the rat gut. The findings provide a basis for further research on host-helminth-microbe correlationships.