bluuebunny/crossref_metadata_2025 huggingface dataset:
PREDICTION OF HEPATOCELLULAR CARCINOMA THROUGH THE MODIFIED PAGE-B SCORE (MPAGE-B) IN PATIENTS WITH CHRONIC HEPATITIS B: IT SHOULD BE USED IN CLINICAL PRACTICE?
Authors: FRISON Paula Roberta , FRAGA Raquel Scherer de
Published: August 2023

ABSTRACT Background: Persistent hepatitis B virus (HBV) infection can lead to hepatocellular carcinoma (HCC) alone, that is, without the development of previous cirrhosis, which makes it of paramount importance to predict the risk patients with chronic hepatitis B have for developing HCC in the future. Thus, the mPAGE-B score was developed in order to predict very low risks of HCC, becoming an important score, since with low risk, patient surveillance can be spread out. Objective: The main objective of this study was to predict the risk of HCC according to the mPAGE-B score for patients with chronic hepatitis B, using antiviral therapy. Methods: A cross-sectional, descriptive, quantitative, and retrospective study was conducted. Patients with chronic hepatitis B from the Hepatology Outpatient Clinic of the Federal University of the Fronteira Sul/HCPF in Passo Fundo, Rio Grande do Sul, covering a period of 12 years, were analyzed. Results: Of the 67 patients submitted to data collection, the mean age at diagnosis was 51.4 (±12.1) years, with a predominance of males (76.1%-n.51). All patients were HBeAg negative at diagnosis and 11 (16.4%) had cirrhosis. Regarding the antiviral regimen, 70.1% used tenofovir disoproxil fumarate (TDF) and 29.9% entecavir (ETV). According to m-PAGE-B stratification, 18 (25%) patients were classified as low-risk, 30 (41.7%) as intermediate-risk, and 19 (26.4%) as high-risk of developing HCC. The probability of developing HCC of these 67 patients in 3 years was 0.4% for low, 2.8% for moderate, and 9% for high risk. In 5 years, the probability was 0.5% for low, 4.4% for moderate, and 14% for high risk. Conclusion: This study demonstrates that the mPAGE-B score can be applied to decrease the number of consultations of patients with chronic hepatitis B in specialized outpatient clinics and, based on this population, patients aged ≤40 years may have one consultation per year instead of semi-annual.
EATING HABITS AND NUTRITIONAL STATUS OF PATIENTS WITH CELIAC DISEASE IN SOUTH BRAZIL
Authors: SGANZERLA Alice , NICOLETTO Bruna Bellincanta
Published: August 2023

ABSTRACT Background: Celiac disease is defined as a chronic autoimmune disease that affects the small intestine in genetically predisposed people, triggered by exposure to gluten. The only treatment for celiac disease to date is a lifelong gluten-free diet. Eating habits of celiacs play an important role in their nutritional status. Objective: To evaluate the eating habits and nutritional status of patients with celiac disease in Rio Grande do Sul. Methods: This is a cross-sectional study with patients diagnosed with celiac disease residing in Rio Grande do Sul (Brazil) over 18 years of age. An online questionnaire was applied with calls through social networks and also by the Associação dos Celíacos do Brasil - Rio Grande do Sul Section. Sociodemographic data, history of celiac disease, general medical history, reported weight and height and food consumption data (SISVAN food frequency questionnaire and general questions) were collected. Results: The sample consisted of 142 individuals with a mean age of 39.75±11.5 years, 94.4% were women and 93% were white. The patients showed care regarding a gluten-free diet, with the majority not ingesting gluten (82.2%) and being careful regarding cross-contamination by gluten in their homes (85.9%) and in restaurants (62, 4%). Most patients also had good eating habits, with frequent consumption of fruits, vegetables, meats, eggs and low frequency of processed foods and fats. Body weight before and after the diagnosis of celiac disease did not show significant changes (62.3±13.8 versus 63.6±11.7 kg; P=0.147); however, there was an improvement in the classification of nutritional status by body mass index (malnourished: 11.6% before versus 2.3% after; P=0.016). Conclusion: Most celiac disease patients in this study have good eating habits with a balanced gluten-free diet and improved nutritional status after diagnosis according to body mass index classification.
LEARNING CURVE IN ESOPHAGEAL ENDOSCOPIC SUBMUCOSAL DISSECTION BY WESTERN ENDOSCOSPISTS TRAINED IN JAPAN: EXPERIENCE IN LATIN AMERICA
Authors: ALIAGA RAMOS Josué , YOSHIDA Naohisa , ABDUL RANI Rafiz , ARANTES Vitor N
Published: August 2023

ABSTRACT Background: Esophageal endoscopic submucosal dissection (EESD) is a complex and time-consuming procedure at which training are mainly available in Japan. There is a paucity of data concerning the learning curve to master EESD by Western endoscopists. Objective: This study aimed to assess the learning curve effect on patient’s clinical outcome for EESD. Methods: This is a retrospective observational study. Enrolling patients that underwent EESD from 2009 to 2021. The analysis was divided into two periods; T1: case 1 to 49 and T2: case 50 to 98. The following features were analyzed for each group: patients and tumors characteristics, en-bloc, complete and curative resection rates, procedure duration and adverse events rate. Results: Ninety-eight EESD procedures were performed. Mean procedure time was 111.8 min and 103.6 min for T1 and T2, respectively (P=0.004). En bloc resection rate was 93.8% and 97.9% for T1 and T2, respectively (P=0.307). Complete resection rate was 79.5% and 85.7% for T1 and T2, respectively (P=0.424). Curative resection rate was 65.3% and 71.4% for T1 and T2, respectively (P=0.258). Four patients had complications; three during T1 period and one during T2 period. Overall mortality rate: 0%. Conclusion: The esophageal endoscopic submucosal dissection could be performed effectively and safely by an adequately trained Western endoscopist.
Formação docente nas universidades brasileiras no período pós pandemia
Authors: Piontkewicz Regiane , Freitas Maria do Carmo Duarte , Mendes Junior Ricardo
Published: August 2023

Resumo A pesquisa analisa como as universidades brasileiras conduzem a formação dos seus docentes no período pós pandemia. Uma pesquisa de levantamento com a participação de 59 universidades (35 públicas e 24 privadas) foi aplicada no segundo semestre de 2021. Os resultados mostram que houve uma evolução em relação à formação docente após o Ensino remoto emergencial, com o aumento da quantidade e diversidade de cursos, abrangência e adesão de mais professores, formações de forma contínua, instituição ou melhoria de planos de formação. Muitos cursos ofertados referem-se ao uso de ferramentas tecnológicas básicas ou tradicionais e foram necessários para a continuidade das aulas de forma remota, no entanto, ainda existem possibilidades de explorar outras ferramentas com outras finalidades de uso, desenvolvendo a Competência Docente Digital. Para sistematizar os planos e programas de formação, sugere-se o uso de ferramentas da Gestão do Conhecimento, mais especificamente o modelo Seci, pois possibilita a conversão entre os tipos de conhecimento e avaliação contínua.
Complexity of Computing the Shapley Value in Partition Function Form Games
Authors: Skibski Oskar
Published: August 2023

We study the complexity of computing the Shapley value in partition function form games. We focus on two representations based on marginal contribution nets (embedded MC-nets and weighted MC-nets) and five extensions of the Shapley value. Our results show that while weighted MC-nets are more concise than embedded MC-nets, they have slightly worse computational properties when it comes to computing the Shapley value: two out of five extensions can be computed in polynomial time for embedded MC-nets and only one for weighted MC-nets.
Coexistence of Posterior Cortical Atrophy and Parkinson’s Disease
Authors: Ko Eun-Byul , Hwang Il-Joong , Kim Jung-Woo , Jung Dar-Eun , Lee Ju-Suk , Yoo Sang-Won , Kim Joong-Seok
Published: August 2023

We report a rare and unique presentation of a patient with early and levodopa-responsive Parkinson’s disease (PD) who exhibited clinical features similar to posterior cortical atrophy (PCA). The imaging evidence suggested the coexistence of PD and PCA, without the presence of amyloid pathology. Although the present case lacks pathologic evidence, this case represents a distinct manifestation of PD characterized by a combination of parkinsonism and early prominent posterior cognitive deficits, reminiscent of the visual variant of Alzheimer’s disease.
Sports Preferences in children and adolescents in psychiatric care – evaluation of a new Questionnaire (SPOQ)
Authors: Florian Breido , Sebastian Stumm , Ekkehart Jenetzky , Michael Huss
Published: August 2023

Background: As part of an exploratory and hypothesis-generating study, the Sports Preference Questionnaire (SPOQ) was developed to survey the athletic behavior of mentally ill children and adolescents, subjectively assessing physical fitness and the perceived psychological effects of physical activity. Methods: In a department of child and adolescent psychiatry, 313 patients (6 years - 18 years) were classified according to their primary psychiatric diagnosis. The patients or - in the parental version of the questionnaire - their parents reported their sports preferences on the SPOQ. As possibly influential factors, also the frequency of physical activity, the importance of a trainer, coping with everyday life through physical activity, and subjectively perceived physical fitness were assessed. Results: One in 3 patients stated that they were not physically active. Patients diagnosed with eating disorders reported, on average, a notably high frequency and degree of coping with daily life through physical activity. Patients with anxiety disorders and depression had the lowest self-perception of physical fitness. The presence of a trainer was generally considered very unimportant, but not in Attention Deficit Hyperactivity Disorder (ADHD) patients. Conclusion: The SPOQ is sensitive to differential effects of core child and adolescent disorders as well as to main covariates influencing the complex association between physical activity and emotional and behavioral disorders in children and adolescents. Based on this pilot study, the need for an efficacy study to measure the effects of sports therapy was discussed.
Characterizing spatial and temporal properties of ER-phagy receptors v1
Authors: Hoyer Melissa
Published: August 2023

The endoplasmic reticulum (ER) has a vast proteomic landscape to preform many diverse functions including protein and lipid synthesis, calcium ion flux, and inter-organelle communication. The ER proteome is remodeled in part through membrane-embedded receptors linking ER to degradative autophagy machinery (selective ER-phagy). A refined tubular ER network is formed in neurons within highly polarized dendrites and axons. Autophagy-deficient neurons in vivodisplay axonal ER accumulation within synaptic ER boutons, and the ER-phagy receptor FAM134B has been genetically linked with human sensory and autonomic neuropathy. However, mechanisms and receptor selectivity underlying ER remodeling by autophagy in neurons is limited. Here, we combine a genetically tractable induced neuron (iNeuron) system for monitoring extensive ER remodeling during differentiation with proteomic and computational tools to create a quantitative landscape of ER proteome remodeling via selective autophagy.Using spatial sensors or ER-phagy we demonstrate receptor-specific autophagic capture of ER in axons.
A Simple Exploration of Simulated Annealing: Protocol v1
Authors: Griego Chasz
Published: August 2023

This protocol describes technical steps to understand the computational environment for A Simple Exploration of Simulated Annealing hosted on Code Ocean.
Bone Marrow Derived Macrophage (BMDM) differentiation and maintenance v1
Authors: Yadavalli Narayana
Published: August 2023

This protocol describes the isolation of bone marrow derived macrophages.
Neural differentiation of AAVS1-TRE3G-NGN2 pluripotent stem cells v1
Authors: Zhang Jiuchun
Published: August 2023

This protocol is about neural differentiation of AAVS1-TRE3G-NGN2 pluripotent stem cells.
Mujer, criolla y “loca”. Autocensura y domesticación de Bertha Mason en la España franquista. Análisis de la traducción de Jane Eyre de Juan G. de Luaces (Iberia, 1943)
Authors: Ortega Sáez Marta
Published: August 2023

Este artículo tiene como punto de partida la otredad en el personaje de Bertha Antoinetta Mason, que aparece en la novela Jane Eyre, de Charlotte Brontë (1847). Conocida como Bertha Mason, la esposa jamaicana criolla de Mr Rochester, vive durante años encerrada en el ático de Thornfield, debido al que se denomina en la novela su “trastorno mental”, uno de los elementos que contribuyen a construir dicha otredad. Además de este condicionante, en el contexto victoriano, la alteridad de Bertha Mason viene determinada por otros dos factores que asimismo le proporcionan una situación de inferioridad, subordinación y opresión: 1) su condición como mujer y 2) su mestizaje. En este estudio se analiza el tratamiento de esta otredad en la primera traducción de Jane Eyre publicada en el franquismo en España, llevada a cabo por Juan G. de Luaces en 1943. Por otra parte, se examina si ha existido (auto)censura en esta versión un siglo después de la publicación del texto inglés, en un contexto de involución hacia modelos ideológicos decimonónicos. Con este propósito se estudia, en primer lugar, el expediente de censura de la traducción; después, se indaga en los agentes involucrados en esta versión y se tienen en cuenta los criterios de censura de la época enumerados por Abellán; también se analizan los contextos de partida y llegada y, finalmente, se lleva a cabo un análisis microtextual para determinar los cambios encontrados en la traducción al español.
La influencia de la corrección política en la traducción de Los Cinco: tipos de intervencionismo y censura en torno al personaje de Jorge
Authors: Soriano García Inmaculada , Rodríguez Domínguez Ana
Published: August 2023

Las aventuras de Los Cinco, de Enyd Blyton, se han convertido, desde la primera publicación en 1942, en un referente juvenil intergeneracional, gracias a su capacidad de adaptación a cada época. Son numerosos los trabajos sobre las distintas modificaciones que ha sufrido esta colección con objeto de adecuarse a los tiempos y a sus correspondientes estándares de corrección política, tanto en Reino Unido como en España. A diferencia de estudios previos sobre el tema, el presente fija el análisis en el personaje de Jorge, sin duda el más rico de la saga, por su carácter rompedor con los roles de género de los años cuarenta. Mediante la comparación de su descripción en fragmentos de la primera novela, observamos cómo ha ido evolucionando tanto en la versión británica como en su traducción y reediciones españolas. En España, siempre a partir de la traducción de Juan Ríos de la Rosa, han sido numerosas las reediciones del primer libro de la saga. Las modificaciones introducidas, relacionadas todas con estereotipos y con el personaje de Jorge, hacen pensar en la influencia que han ejercido en todo momento los contextos ideológicos y socioculturales.
News Representation and Sense of Belonging Among Multicultural Audiences
Authors: Park Sora , Lee Jee Young , McGuinness Kieran , Griffiths Rebecca , Nguyen Thu
Published: August 2023

This study seeks to understand the role of representation in news media, trust in news, and participation in multicultural audiences’ sense of belonging to society. A multimodal survey combining online, CATI, and CAPI methods was conducted in Australia at the end of 2021 and early 2022 (N = 1,084). The top five non-English language communities in Australia (Arabic, Cantonese, Italian, Mandarin, and Vietnamese) were included in the survey, of which n = 851 were born overseas. The findings reveal a significant link between the perception of sufficient representation in Australian news media, trust in news, confidence to participate in society, and sense of belonging. When multicultural audiences see themselves fairly and adequately represented in the news, they are more likely to trust the news and participate in the community by discussing the news and current affairs. This, in turn, leads to a stronger sense of belonging to society. We also found confidence in English and time spent in Australia were important factors contributing to perceptions of representation. While the length of stay has a positive impact on the perception of representation among those with high confidence in English, this perception is significantly lower among those who have lower confidence. This result confirms the significant role language proficiency plays in migrants’ experiences in the host country.
Urban environmental pollution in external and internal environments by PM2.5 particulate matter and the sick building syndrome: an overview
Authors: Da Silva Civeira Matheus , Dalmora Adilson Celimar , Do Nascimento de Campos Samuel , Gaspar Hernández Palma Hugo
Published: August 2023

Abstract

A healthy environment must have air free of pollution, but this issue has always existed and now affects the entire population. The PM2.5 particulate matter, which primarily originates from the car fleet, is one of the pollutants that has the biggest impact. With the energy crisis in the 1970s and the ensuing construction of closed buildings (without natural ventilation), primarily in developed countries, indoor air quality emerged as a science. It then gained importance when it was found that the declining ventilation levels in those nations were largely to blame for the rising concentrations of pollutants in indoor air. The occupants of buildings themselves make a considerable contribution to the pollution of these settings through their activities, and it is well acknowledged that poor ventilation is one of the most critical factors affecting indoor air quality. Sick building syndrome and poor indoor air quality are both connected to ailments like colds, allergies, and coughing. The application of special legislation must be integrated with research and education of building occupants to effectively provide a healthy environment. The goal of this review is to analyze various findings from investigations on the effects of PM2.5 particulate matter pollution on the internal and exterior urban environment, as well as the effects of these concentrations on human health. By comparing the findings with other studies, it is possible to compare the findings and identify some common behaviors of fine particles, determining the concentration differences in the environments and showing how different sources and conditions can produce different variations in concentrations.
Changes in mortality rates and hospital mortality associated with bronchial asthma in the population of the Russian Federation (2014 – 2018)
Authors: Bystritskaya E. V. , Bilichenko T. N.
Published: August 2023

Bronchial asthma (BA) is one of the leading chronic non-communicable diseases in all age groups and has been noted by WHO and GINA due to the large socio-economic burden on society. Aim. The analysis of mortality rates (MR) and hospital mortality (HM) due to BA in the Russian population in 2014 and 2018. Methods. The statistical information of the Ministry of Healthcare of the Russian Federation and Federal State Statistics Service of the Ministry of Economic Development of the Russian Federation on the MR and HM associated with BA was used. Results. The mortality rate (MR) associated with BA in Russia was 1.2 per 100 thousand population in 2014 and 0.9 in 2018, which corresponded to 2% of mortality from all respiratory diseases. The maximum MR was registered in the Volga Federal District (in 2014 – 1.7, in 2018 – 1.1 per 100 thousand population). Among the working age population, the average MR due to BA was registered at the level of 0.4 per 100 thousand in 2014 and 0.3 in 2018. Among the population older than working age, MR was 4.2 in 2014. In 2018, MR due to BA decreased by 1.5 times to 2.7 per 100 thousand in the older age group (p = 0,026). MR due to BA in the urban population in 2018 was 2 times higher than in the rural population, and was 1.6 times higher in women than in men. Hospital mortality (HM) in the adult population in 2014 and 2018 stayed at the level of 0.3%. Conclusion. The early diagnosis and follow-up of patients with asthma and control of asthma among different age groups contribute to gradual decrease in MR.
Mixed bacterial-viral lung infections in patients with cystic fibrosis
Authors: Burmistrov E. M. , Krasnoslobodtsev K. G. , Avetisyan L. R. , Siyanova E. A. , Medvedeva O. S. , Tselikina E. G. , Polyakov N. B. , Solovyev A. I. , Voronkova A. Yu. , Kondratyeva E. I. , Krasovskiy S. A. , Zhukhovitsky V. G. , Burtseva E. I. , Nikitenko N. A. , Chernukha M. Yu.
Published: August 2023

The main cause of death in patients with cystic fibrosis (CF) is infectious process in the lungs, in particular, chronic lung infections caused by various pathogens, most often a combination of bacteria, fungi, or viruses. Data on mixed bacterial and viral-bacterial infections from domestic and foreign sources are fragmentary and sparse. The dominant associations of bacterial and viral pathogens in patients with cystic fibrosis have not been studied properly, and data on their epidemiological significance are lacking. The aim of this study was to assess the prevalence of bacterial and viral infections in patients with cystic fibrosis and to substantiate the need for the development of virological monitoring. Methods. Biomaterials from the respiratory tract of CF patients (409 children and 160 adults with CF) examined from 2006 to 2022 were used. The study was carried out using bacteriological methods, molecular genetic methods (RT-PCR) and MALDI-TOF mass-spectrometry. Results. Microflora of the respiratory tract was shown to be mixed in 2/3 patients with CF. The microflora of the lungs of children with CF is a dynamic community of microorganisms with high diversity and variability. In adult patients, associations of microorganisms are more common than in children, but the composition of associations is less diverse. We isolated about 40 species of bacteria from adult patients and more than 85 species from children in our sample. NFMO prevailed, including Burkholderia cepacia complex, Pseudomonas aeruginosa, Achromobacter xylosoxidans, Achromobacter ruhlandii, Stenotrophomonas maltophilia, and Staphylococcus aureus, Candida albicans, Aspergillus spp. Real-time PCR showed the presence of rhinovirus RNA in 10% of samples obtained from children and 12.9% from adults with cystic fibrosis. Conclusion. Our results indicate the need for continuous monitoring of the lung microflora in patients with CF, including testing for viruses.
Using colistimethate sodium in complex therapy of cystic fibrosis in children under 6 years of age
Authors: Petrova N. V. , Simonova O. I. , Gordeev L. S. , Anai-ool C. G. , Samoilova E. A.
Published: August 2023

Early and adequate antibacterial therapy of airway infections in patients with cystic fibrosis (CF) may lead to decrease in chronic inflammation, delay the worsening of pulmonary function, and prevent the selection of resistant bacteria. Inhaled forms of antibiotics, which can help to achieve high concentrations of drug in airways and minimize systemic adverse reactions, are particularly important when treating children under 6 years of age. Purpose. To evaluate effectiveness of combined therapy and tolerability of therapy with inhaled colistimethate sodium when treating exacerbations of infectious process in children with cystic fibrosis under 6 years of age. Methods. A retrospective analysis of medical records of patients with CF and infections caused by Pseudomonas aeruginosa who were admitted to pulmonology department of Federal State Autonomous Institution “National Medical Research Center for Children’s Health” of the Ministry of Health of the Russian Federation from June of 2021 to March of 2023 and who were treated with inhaled colistimethate sodium. Results. 20 courses of therapy in 17 patients with cystic fibrosis under 6 years of age were recorded. Mean duration of treatment was 10.4 days (4 – 19 days). There were no adverse reactions that led to discontinuation of the treatment. Clinical and microbiological effectiveness of the combined therapy was 60%. Conclusion. Therapy of exacerbations of airway infections caused by P. aeruginosa with inhaled colistimethate sodium was well tolerated by patients under 6 years of age. No adverse drug reactions were reported.
Skin test based on Mycobacterium tuberculosis antigens (ESAT-6 and CFP-10) for the detection of tuberculosis infection in world practice
Authors: Russkikh O. E. , Savintseva E. V. , Kudlay D. A. , Doktorova N. P. , Sysoev P. G.
Published: August 2023

According to experts, 2 billion people in the world are infected with the causative agent of tuberculosis. A priority task in the diagnosis of tuberculosis infection is the use of accurate, accessible and scalable tools. The tuberculin skin test (TST), or Mantoux test, and the interferon gamma release assay (IGRA) are currently used to diagnose tuberculosis infection. In 2022, the World Health Organization (WHO) identified a fundamentally new class of skin tests for the early detection of tuberculosis infection, the so-called Mycobacterium tuberculosis antigen-based skin tests (TBST). These tests include Diaskintest (Russia), C-Tb (India), and C-TST (China) and pose an alternative to the tuberculin skin test and the IGRA. The aim of this work was to conduct a systematic review of domestic and foreign literature sources on the use of a new skin test based on M. tuberculosis antigens (ESAT-6 and CFP-10) to detect tuberculosis infection (Diaskintest) in world practice. Conclusion. According to the literature data, including the published results of meta-analyzes on the use of skin tests, it has been shown that recombinant tuberculous allergen test, as a new skin test based on M. tuberculosis antigens (ESAT-6 and CFP-10), or TBST, has high sensitivity and specificity for the detection of tuberculosis infection. Its sensitivity and specificity are significantly higher than those of the tuberculin test. TBST skin test results are comparable to those of IGRA, have a favorable safety profile, combined with high laboratory test specificity and ease of performance and assessment of the result in one cut (cut-off > 0 mm – any size papule is considered positive). Thus, TBST is a valuable tool for early detection of TB infection. Taking into account the volume of scientific clinical studies on recombinant tuberculous allergen test in the world practice, more than 10 years of experience in clinical practice in Russia and the CIS countries, it can be concluded that recombinant tuberculous allergen test is currently the leading test for mass diagnosis of tuberculosis infection not only in Russia, but also in the world.
Bronchial asthma resistant to pharmacotherapy: why there is no response to the treatment?
Authors: Amirova T. O. , Fabrika M. P. , Soldatov D. G. , Kuneevskaya I. V. , Kameleva A. A.
Published: August 2023

Despite the obvious and simple diagnosis, in practice we meet patients who do not respond to standard therapy. Why does drug resistance occur? The answer to this question is not unambiguous and requires careful investigation in each clinical case. Here we present a clinical case of a patient with bronchial asthma, who had no bad habits and occupational hazards and received adequate drug therapy. However, her condition worsened from attack to attack. Whole exome sequencing by NGS allowed us to determine the spectrum of pathogenic mutations which contribute to the pathological process and drug resistance. Atopy due to dysfunction of filaggrin gene (FLG) triggered the disease and supported the pathological process that led to bronchial asthma. Furthermore, the patient’s body is not able to neutralize the bacterial flaggelin. The inflammatory response is reduced due to а Toll-like receptor 5 (TLR5) deficiency. This is one of the mechanisms underlying development of allergic bronchial asthma. In addition, the patient has reduced cross-presentation of antigens by dendritic cells, that is, a reduced immune response in the absence of infection, due to the complete loss of UNC93B1 gene function. Conclusion. Thus, an atopic reaction based on reduced adaptive immunity led to severe IgE allergy and torpid course of bronchial asthma. This conclusion supports atopic sensitization as the target for therapeutic action and the main core of pathological processes. For this purpose, we used a monoclonal antibody omalizumab that is capable of binding and reducing the amount of IgE. Targeted treatment of bronchial asthma made it possible to interrupt the symptoms and achieve complete remission.
The Loss of the Sense of Sin and the Arrogance of Life: Challenges for Today’s Evangelization
Authors: Nykiel Krzysztof
Published: August 2023

At the beginning of 2014, during his morning meditations, Pope Francis, when referring to a famous phrase by Pius XII, stated that losing the sense of sin is the evil of this civilisation, an evil that strengthens Christian mediocrity and is inversely proportional to directing attention towards – and constructing – the Kingdom of God among men. The categories of sense of sin and sense of guilt, at least in theory and without generalisations, become understandable in the context of the Christian experience and the ecclesial consciousness; yet, when the human horizon is extended, the two concepts do not find a right to citizenship because the question is not even raised. The children and creators of contemporary culture, the men and women of our time, although directed towards the Kingdom of God, are strongly influenced by the global and plural secularist mentality, and this has a negative impact on their attitudes, behaviour and expressions of their existence. The Church, both within herself and outside herself, poses to herself the question of how she can redirect the expressions of this unprecedented anthropology towards Gospel values. The problem is not so much how to bring to the surface the sense of guilt and sin but, rather, how to restore or generate faith in the hearts of men. Effective evangelisation has the task of bringing back the Gospel into men’s hearts and educating in a sense of God so that contemporary man can have a higher paradigm (God) on which to base himself.
Сравнительный анализ современных программных средств автоматизации сметных расчетов
Authors: Горбачѐв А.Ю. , Гулякин Д.В. , Ласкарев А.И.
Published: August 2023

В наши дни, технологии, несомненно, развиваются в самых разных сферах нашей жизнедеятельности, технологические аспекты программного обеспечения, постоянно совершенствуются. Строительная сфера не остается в стороне, ведь данная отрасль требует повышенного внимания ко всем деталям процесса строительства: начиная расчета бизнес плана и сметной стоимости и заканчивая сдачей объекта строительства. В данной статье рассмотрена именно экономическая составляющая строительства, а именно, программы автоматизации сметных расчетов. Проведен сравнительный анализ наиболее распространенных программных комплексов, а также сделаны выводы о преимуществах и недостатках рассмотренных вариантов.
Determinant Factors of Training Result Implementation of General and Covid-19 Corpse Handling Forensic Department of Drajat Prawiranegara Hospital
Authors: Agung Riyanto Dwi , Nurliana Lia , Machron Chairulfalah A. , . Nurjaman
Published: August 2023

This study aims to determine the factors that influence the results of the training for the general burial of corpses and the bodies of COVID-19 for the forensic section of the Serang Hospital in 2021. The research design uses cross-sectional quantitative method, the research sample were all 150 respondents of the general corpse and Covid-19 corpse handling training participants. Quantitative data collection was obtained by providing a questionnaire that has been developed about the factors that affect the implementation of the results of the training to former training participants sent via email or sent directly. The analytical technique used in testing the hypothesis is structural equation modeling (SEM). The measurement of research variables was carried out using formative indicators, where the indicators describe constructs. The technique used to analyze the variables of this research was SEM with the XLSTAT PLS-PM program. Implementation of the results of the funeral training includes socialization, cadre, organizing, and counseling. The implementations that have been carried out by the trainees in each unit/section and 3 arrangements for the funeral procession are socialization (28.77%), cadre (6.85%), organizing (2.74%), and counseling (21.9%). Based on the results of the implementation, it can be seen that the lowest implementation in the three settings is cadre and organization. The implementation of cadre and organization is mostly carried out only in units/sections and in several settings (1 or 2 orders). The results on the assessment on the outer model, for the supporting factor variables, show that the variable that has the biggest influence is legality with an outer weight value of 0.394, while the other variables are not significant because they have an outer weight value below 0.2. The most significant inhibiting factor variables are negotiation failure variables with an outer weight value of 0.225 and a weak coordination variable with an outer weight value of 0.332.
Keywords:
The Effect of Cucumber Juice on Lowering Blood Pressure Among Hypertensive Patients: Literature Review
Authors: Sustiyono Agus , Ismanti Riffa , Nurhayati Siti , Dahlina Ulinuha
Published: August 2023

Hypertension is a common disease in Indonesia and can affect all social, economic, and age groups. Hypertension patients whose blood pressure is consistently elevated will live dependent on drugs and regularly visit doctors for examinations and prescriptions. Cucumber has hypotensive properties because the water and potassium content in cucumber attracts sodium to the intracellular system and works by opening blood vessels (vasodilation), thereby lowering the blood pressure. This study aims to analyze the effect of giving cucumber juice on reducing blood pressure in patients with hypertension. This research is based on the literature review method. Articles were collected through an electronic database and Google Scholar, Garuda Portal, the National Library of the Republic of Indonesia, Academia.edu, and ResearchGate using the keywords: hypertension, blood pressure, cucumber juice. The results showed that the analysis of several studies conducted related to the administration of cucumber juice, namely five journals, concluded that it could reduce blood pressure in the intervention group, and also experienced a decrease in the control group. The control group experienced a less than maximal decrease in blood pressure. Frthe results of the study also showed that giving cucumber juice that was not according to the dose did not have an effect in reducing blood pressure. The results of the examination carried out in the intervention and control groups turned out to have differences in reducing blood pressure, even though the measurement results did not show the maximum value. But in general, measurements made in the intervention group were shown to decrease blood pressure.
Keywords: cucumber, blood pressure, hypertension
Factors Influencing Blind Adolescents' Reproductive Health Behaviors, in Sukabumi
Authors: Haryani Hana , Mohd Said Faridah , Syazana Nur
Published: August 2023

Adolescents with disabilities or special needs are very vulnerable to various health problems including reproductive health. In helping to maintain reproductive health, of course, there needs to be other factors that can support the achievement of reproductive health maintenance such as sources of information, knowledge, and attitudes. This study aims is to determine the influence of sources of information, knowledge, and attitudes toward the reproductive health of blind adolescents in the Sukabumi. A source of information is a set of useful information to meet the need for information or news for the wider community. Knowledge is the result of knowing and this happens after a person performs sensing of an object. Attitude is the readiness to react to an object in a certain environment as a passion for an object. Behavior is a person’s response or reaction to a stimulus. This type of research is correlational with the cross-sectional approach. Total sampling was used for the population and sample of 42 blind adolescents in Sukabumi. Statistical analysis was done using multiple linear regression. The results showed that there was a significant influence of information sources on the reproductive health behavior of blind adolescents (p-value 0.000), there was a relationship of knowledge on the reproductive health behavior of blind adolescents (p-value 0.000), and there was knowledge of attitudes toward reproductive health behaviors of blind adolescents (p-value 0.000). There is a simultaneous influence of sources of information, knowledge and attitudes towards reproductive health behaviors of blind adolescents (p-value 0.000). It can be concluded that sources of information, knowledge, and attitudes have an influence on the reproductive health behavior of adolescents with visual disabilities. This study’s findings can be used to further investigate reproductive health in blind adolescents.
Keywords: adolescents, behavior, blind disability, knowledge, reproductive health, sources of information How
The Effect of Intervention Package Massage Therapy, Music Therapy, and Aromatherapy (P, M, A Therapy) on Breast Milk Adequacy
Authors: Stia Pusporini Lenny , Musfirowat Fifi , Nurjamilah Siti , Puspasari Ayu Ike
Published: August 2023

Effective breastfeeding is the main effort to create optimal life and baby viability. Breastfeeding that is not optimal can be affected by maternal and baby factors. Optimization of breastfeeding can be done with complementary therapy, such as massage therapy, music therapy, and aromatherapy. This study aims to find out the effect of intervention package massage therapy, music therapy and aroma therapy (P, M, A Therapy), on breast milk adequacy at Baros Public Health Center. This study used a quantitative research design, Quasy Eksperimental research design with pre and posttest without control with a research sample of 20 respondents that was taken by using a total sampling technique. The study’s result average respondent before an intervention was 35,85, standard deviation 2,560, CI 95% 34,63-37,05. The average respondent after an intervention was 40,35, standard deviation 2,834, CI 95% 39,02-41,68. The results of the statistical test obtained p-value of 0,00 and 0, it was concluded that there was an effect of the PMA therapy on breast milk adequacy. We hope that in future this intervention package can be developed for achieving optimal breastfeeding.
Keywords: intervention package, massage therapy, music therapy, aromatherapy (P, M, A therapy), breast milk
Traditional Indonesian Medication Combats COVID-19
Authors: Yanuar Arry , Hasanah Nur , Chany Saputri Fadlina , Bustamam Alhadi
Published: August 2023

In Indonesia, the number of cases infected with Covid-19 peaked between mid-June and August 2021, resulting in the denial of hospital treatment to some people due to insufficient capacity. Therefore, people treat themselves by using natural ingredients. This study aims to identify plants that can treat Covid-19 with self-medication. This study took a description approach to investigate people using traditional herbs in self-medication for COVID-19 recovery. Snowball sampling is the approach used. Interviews and an online system (gform) were used to collect data. The number of samples collected allows for a more thorough analysis of the 104 respondents. The results showed that women (51.0%), people aged between 56 and 65 (52.9%), Banten residents (32.7%), secondary education (57. 7%), and people with comorbidities (86.5). %) were all interested in using traditional herbal medicine. Reduction of symptoms and results of laboratory tests were used to measure recovery. The most common comorbidities were hypertension (7-14 days to recovery), diabetes mellitus (15-21 days to recovery), and cardiovascular disease (7-14 days and 15-21 days to recovery). The Zingiberaceae family dominates traditional herbs. The most widely used traditional ingredients are Empon-Empon, which consists of red ginger, turmeric, nutmeg, aromatic ginger, bay leaves, lemongrass, galangal, cinnamon, and cloves. The average healing time is 7-14 days (32.7%). In conclusion people who utilized herbal medicines reported a speedy recovery and reduction in the severity of their symptoms.
Keywords: Covid-19, Empon-Empon, herbal medicine, self-medication, traditional ingredients
The Relationship Between of Knowledge Parenting and Food Intake on the Incidence of Stunting in Toddlers in Sukabumi Regency
Authors: Novianti Utami Rima , Letchmi Pandarugan Santhna , Nambiar Nisha
Published: August 2023

Stunting is a condition where the measurement of height does not match or is less than the age of growth and development in children under five. The growth and development of children in infancy is important because brain cells are still growing. This study aims to determine the relationship of the knowledge, parenting, and food intake in stunting toddlers. The population was all stunting toddlers in Sukasari Village Sukabumi Regency, with a sample size of 88 participants. For sampling, purposive random sampling was used. The instrument has been verified and shown to be reliable. The relationship between knowledge with incidence of stunting was significant with p-value 0.000 (add correlation coefficient). The effect of food intake on the incidence of stunting with p-value 0.000. The effect of parenting on the incidence of stunting with p-value 0.000. According to the results of the study, knowledge, parenting, and food intake all affect the incidence of stunting. Expected to optimize nutrition counseling and health promotion to families.
Keywords: knowledge, parenting, food intake, stunting
Parents' Decision-making Experience in Choosing the MMR Vaccine in Banten, Indonesia
Authors: Nugraha Kusuma Andiko , Nasiatin Titin , Sansuwito Tukimin
Published: August 2023

Research has extensively studied parental vaccination decision-making drivers and barriers. The most powerful predictors of vaccination actions include the understanding of the risks posed by the disease; and the side effects of vaccination; vaccine beliefs and attitudes; and their effectiveness and safety concerns. Thus, this study aimed to explore the parents decision-making experience in choosing MMR vaccine in Banten, Indonesia. In qualitative study, a purposeful sampling process was used to identify parents with a variety of expected MMR decisions: (1) accept MMR on time, (2) accept MMR late, (3) receive one or more individuals, (4) obtain no MMR or individuals. A qualitative quality analysis was used to interpret the transcribed text. A total of 25 participants from 5 different FGDs were included in this study. This qualitative interview resulted in 4 themes, namely: healthy life, own health perceptions, disease history, perceived severity, and susceptibility of vaccine-preventable illnesses. Research on the MMR vaccination should move a step forward and include studies looking at similarities and differences in the factors predicting parents’ intention to follow MMR vaccination recommendations by comparing parents of very young children, being the primary target group of MMR vaccination campaigns and interventions, with parents of adolescent children.
Keywords: decision process, MMR vaccine, qualitative study
Prevalencia y factores asociados al desarrollo de COVID severo
Authors: Fernández Collahuazo Cristina Nataly , Guevara Pacheco Sergio Vicente , Encalada Torres Lorena Esperanza
Published: August 2023

Introducción: la enfermedad por coronavirus SARS-CoV2 (COVID-19) de letalidad variable y amplia propagación a nivel mundial, presenta cuadros severos asociados con edad y sexo; y comorbilidades como: hipertensión arterial, enfermedades cardiovasculares, diabetes, enfermedad renal crónica y obesidad. 
Objetivo: establecer la prevalencia y factores asociados a COVID severo en pacientes ingresados en el Hospital Vicente Corral Moscoso (HVCM).
Metodología: estudio transversal analítico de pacientes atendidos en el servicio de medicina interna; las variables analizadas fueron edad, sexo, diagnóstico COVID-19, comorbilidades: hipertensión arterial (HTA), enfermedades cardio vasculares (ECV), diabetes, enfermedad renal crónica (ERC), obesidad, COVID severo; se realizó estadística descriptiva con porcentajes y frecuencias, medidas de dispersión y tendencia central; se determinó asociación con el estadístico chi cuadrado y para establecer el sentido e intensidad de relación el OR en conjunto con sus intervalos de confianza. El procesamiento de la información se lo realizó en el programa estadístico SPSS 25 y se consideró una significancia del 5% (p<0.05).
Resultados: de 1 472 atendidos, presentaron COVID-19 (28.87%), 216 hombres (51%) y 209 (49%) mujeres. De los 425 con COVID-19 fueron diagnosticados de formas severas 52.2%; entre las comorbilidades que se asociaron a gravedad se encuentran: hipertensión arterial 65.69% (p<0.01; OR 2.26 IC 95% 1.48-3.45), enfermedad renal crónica 76.47% (p<0.01; OR 3.09 IC 95% 0.99-9.65) y obesidad 69.79% (p<0.01; OR 2.59 IC 95% 1.59-4.21).
Conclusiones: la prevalencia de COVID-19 fue 28.87%, el 52.2% presentó complicaciones en el HVCM siendo más frecuente en el sexo masculino y adultos mayores. El ser adulto mayor y padecer comorbilidades como hipertensión arterial, enfermedad renal crónica y obesidad son factores de riesgo relacionados a severidad.
Nasoangiofibroma juvenil: reporte de caso
Authors: Deleg Guartán Ruth Carolina , Siguencia Siguencia Angélica Gabriela
Published: August 2023

Introducción: el nasoangiofibroma juvenil (NAFJ) es una neoplasia vasculotumoral agresiva, de histología benigna, con preferencia por el sexo masculino, en edades prepúberes y púberes. En el tratamiento quirúrgico la anestesia es un desafío al compartir campo operatorio con el cirujano con el alto riesgo de sangrado, así como morbi-mortalidad por la hemorragia que genera y por la destrucción local secundaria a su patrón de crecimiento.
Caso clínico: varón de 13 años de edad con diagnóstico de NAFJ, con epistaxis recurrente, ronquido y obstrucción nasal que empeora progresivamente, al examen físico se observa tumoración nasal izquierda, en el laboratorio reportó hemoglobina de 5,1 g/dl; se decide cirugía de emergencia (resección tumoral vía osteotomía tipo Le Fort 1). Previamente se transfundieron concentrados globulares, hemodinámicamente estable. Como anestesiología se procedió a realizar un buen manejo de la vía aérea conjuntamente con el cirujano se exterioriza el TET a través de una disección submentoniana (secuencia de Altemir), un adecuado monitoreo hemodinámico, manejo de líquidos guiado por metas, autotransfusión autóloga mediante el uso del cell saver optimizando y disminuyendo el riesgo de sangrado, y monitorizando la necesidad de transfusión de hemoderivados dirigida e individualizada mediante el uso del tromboelastograma transoperatorio. Terminado procedimiento quirúrgico fue trasladado a la Unidad de Cuidados Intensivos Pediátricos (UCIP), con evolución favorable fue dado de alta y mejoría significativa en controles por consulta externa.
Conclusiones: el abordaje de un paciente con NAFJ es un desafío para el anestesiólogo, previo a la cirugía se transfundieron concentrados globulares, se realizó abordaje anestésico con intubación orotraqueal, durante el acto quirúrgico se emplearon medidas para optimizar y disminuir el sangrado con antifibrinolíticos, hipotensores y cell saver, paciente evoluciona favorablemente.