bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Taoism in the Development of Images of Gardens and Parks in Chinese Art
Authors: Lu Sa
Published: November 2022

The article reveals the role of Taoism in the development of images of gardens and parks in Chinese art. Taoism is considered as a spiritual component of the traditional culture of China, affecting all spheres of human essence, including its expression in the visual arts. The problem of this study is to show how the Taoist ideas about man and the world around him were expressed in the works of landscape painting of the V–XIV centuries, when both the formation and development of the art of depicting nature and the formation of the fundamental principles of landscape planning took place. Both phenomena of Chinese culture were obviously influenced by Taoism, so the focus is on picturesque images of gardens and parks and the means of their artistic embodiment, which were formed as a result of the influence of philosophical and religious ideas.   The purpose of the publication is the stylistic and semantic analysis of Chinese medieval landscapes depicting garden and park ensembles and elements formed under the influence of Taoist aesthetics. Such a perspective should enrich Russian science with new information about the formation and enrichment of the figurative series in the landscapes of Chinese masters over a long period of time, as well as evaluate the originality of their visual interpretation of philosophical and aesthetic ideas. This will allow us to see how the images of gardens and parks conveyed through the symbolism of images the inner world of a person and the authors themselves, how the ideas of the Taoists associated with these images manifested themselves not only in the subject of paintings, but also in an artistic form.
Vietnamese Tutelary Spirits (Thành Hoàng): History Of the Cult and its Current State
Authors: Gordienko Elena
Published: November 2022

This article discusses the cult of the tutelary spirits (thành hoàng) in Vietnam. These are spirits venerated as patrons of villages, rural communities and urban areas in Vietnam are expected to protect area against calamities, disasters, epidemics, wars, etc. These are mythical, historical and pseudo-historical characters who have merits to the area and its inhabitants. The veneration of them is rooted in the traditional culture. It is an integral part of the Vietnamese folk religion (tín ngưỡng dân gian Việt Nam). The spirits of the area are included in the pantheon of numerous deities and spirits (thần) worshipped by the Vietnamese nowadays despite the anti-religious policy of the Communist Party of Vietnam (in the second half of the 20th century). The article describes reconstruction of the history of the cult and a description of its current state. The milestones of its development are considered: the formation of the cult during the Late Lê dynasty (1428–1788), development trends during the Nguyễn dynasty (1802–1945), which included the period of colonization of Vietnam by the French, the decline of the cult in the second half of the 20th century in socialist Vietnam, the revival of the cult and the entire religious system with the beginning of economic reforms and the democratization of public life in the 1980-90s, and finally, the modern flourishing of the cult and the features of its adaptation to modern conditions. The definition of the historical forms of the cult allows to identify the dynamics in its development and describe the inevitable transformations of the cult in the 21st century, which often are not realized by the bearers of culture, who perceive the cult as an ancient unchanging tradition. The cult has not previously been studied by Soviet and Russian orientalists. I propose the first systematic description of the history of the cult and an assessment of its current state.
Death of The Limited License to Data: United States v. Van Buren
Authors: Curley Nick
Published: November 2022

The United States Supreme Court has normally viewed data as property. Yet in United States v. Van Buren, the Court abandoned the property law angle. Van Buren included examination of the Computer Fraud and Abuse Act’s applicability to a police officer who accepted a bribe from undercover agents to look up a phony license plate. The Court held that under the CFAA someone only “exceeds authorized access” when they properly access a computer and then improperly access files “that are off limits to [them].”

This Case Note explores why the Supreme Court should not have abandoned the property analogy to data. The Court is wrong because it has effectively destroyed the limited license to data. Further, the Court’s analysis of the underlying technology leaves several questions unanswered for companies seeking to protect their data and employees looking to comply with the CFAA. For instance, users may have different levels of authorized access such as “Read” or “Write” permissions. But the Court merely approached data with an on/off false dichotomy. Van Buren ignores the nuance of data authority in the modern age.
In the Midst of a Global Pandemic: Benefits of a Biomedical Patenting Regime
Authors: Nguyen Amy Q.
Published: November 2022

There has long been a debate centered around genomic and biomedical data patenting. The opposition expresses concern that the patenting of genomic and biomedical data will hinder the manufacturing and distribution of medical and scientific discoveries to those who need them. On the other hand, supporters of patenting genomic and biomedical data explain that patents are beneficial. For example, genomic and biomedical patents allow pharmaceutical companies and research labs to recoup their massive investments in researching and developing new medical and scientific methodologies and technologies. Patents also incentivize these companies to make discoveries to prevent future pandemics and diseases.

In 2020, the COVID-19 pandemic broke out and left the world struggling to create more effective vaccines to combat the virus and its variants. At the center of this battle against the virus, various pharmaceutical companies, such as Pfizer, Moderna, BioNTech, and Arcturus, have been working endlessly to develop possible vaccine candidates for the COVID-19 vaccine. The question of whether these pharmaceutical companies will be allowed the protections afforded by genomic and biomedical patenting to spur more advances in the fields of science and medicine to combat new viruses has come to the forefront once again.

With two landmark Supreme Court cases that discuss the patenting of biomedical data and genomic processes, the U.S. Supreme Court has barred the patenting of isolated DNA and naturally occurring processes. However, amid a global pandemic, there are benefits to patenting biomedical data. The U.S. Patent Regime should allow genomic and biomedical data patenting to encourage innovation and incentivize researchers and scientists by taking measures to broaden the scope of patent-protected subject matters and by adopting aspects of foreign patent regimes, such as Japan’s patent regime, to expand the treatment of patent protection and encourage innovation in biotechnology and medicine.
Antifungal stewardship: What we need to know
Authors: Ray Arunima , Das Anupam , Panda Saumya
Published: November 2022

Antimicrobial stewardship refers to a well-coordinated program which promotes the scientific and rational use of antimicrobials, reduces the chances of drug resistance and improves patient outcomes. A comprehensive English language literature search was done across multiple databases (PubMed, EMBASE, MEDLINE and Cochrane) for the period 1990-2022, revealing a large volume of reports of growing resistance to established antifungal therapies, against a backdrop of irrational and unscientific prescriptions. As a result of this, antifungal stewardship, a new kid on the block, has recently garnered attention. This review article is an attempt to summarise the basic concept of stewardship programs, highlighting the dire need to implement the same in the present situation of antifungal resistance and treatment failure.
Electrocardiographic changes in patients with raised intracranial pressure from supratentorial brain tumors
Authors: Sethuraman Manikandan , Hrishi Ajay Prasad , Prathapadas Unnikrishnan , Ajayan Neeraja
Published: November 2022

Objectives:

A wide variety of electrocardiographic (ECG) changes has been described in the context of neurological catastrophe. There has been diverse and plentiful literature emphasizing the cardiac changes in acute cerebrovascular events and traumatic brain injury. In stark contrast, there is scarce literature on the incidence of cardiac dysfunction caused by raised intracranial pressure (ICP) resulting from brain tumors. The study aimed to observe the ECG changes concurrent with intracranial hypertension resulting from supratentorial brain tumors.

Materials and Methods:

This is a pre-specified subgroup analysis of a prospective and observational study on cardiac function in patients presenting for neurosurgery. Data of 100 consecutive patients of either sex between 18 and 60 years who presented with primary supratentorial brain tumors were analyzed. The patients were divided into two groups: Group 1 consisted of patients without clinical and radiological features of raised ICP and Group 2 consisted of patients with clinical and radiological features of raised ICP. A 12-lead ECG was obtained for every patient on the day before the neurosurgical procedure as part of the pre-anesthetic assessment. The cardiologist and the neuroanesthetist independently examined the ECG, and it was then classified and coded as per the standardized Minnesota code. Statistical analysis was performed with IBM SPSS (release 22.0; IBM Corp., Armonk, NY, USA). The normality of the distribution of continuous variables was tested using the Shapiro–Wilk test. Normally distributed variables were expressed as Mean ± SD. All nominal or categorical variables are described as frequencies and percentages. Categorical variables were compared using the Chi-square test or the Fisher’s exact test. The normally distributed continuous variables were compared using Student’s t-test. “P < 0.05” was considered statistically significant.

Results:

About 6% in Group 1 and 32% in Group 2 had abnormal ECG. This was significantly different in Group 2 compared to Group 1 (P < 0.05). No patients in Group 1 had sinus bradycardia, whereas it was observed in 12% of the patients in Group 2 (P = 0.02). ST-segment depression was found in 12% of patients in Group 2, whereas none had it in Group 1 (P = 0.02). ST-segment elevation was noticed in 16 % in Group 2 and 2% in Group 1 (P = 0.01). T-wave abnormalities were found in 16% compared to 4% in Group 1 (P = 0.03).

Conclusion:

In patients with supratentorial tumors, we observed that those with raised ICP had a higher incidence of ECG changes than those with normal ICP. In addition, repolarization abnormalities and arrhythmias were significantly higher in patients with raised ICP.
Cerebellar restricted diffusion in Wernicke’s encephalopathy
Authors: Arulprakash Narenraj , Shah Vishank
Published: November 2022

A 50-year-old woman presented to an outside hospital for acute onset bilateral lower limb pain. She was diagnosed with aortoiliac stenosis and underwent stent placement. Post-procedure, she was noted to have altered mental status, truncal ataxia, neck titubation, and incomplete external ophthalmoplegia. She rapidly declined to a stuporous state. She had a history of uterine cancer treated with chemoradiation which was complicated by chronic radiation enteritis. She was also reported to have poor oral intake, recurrent emesis, and weight loss for a month before her presentation. After an extensive work up, she arrived at our facility where an MRI of the brain showed restricted diffusion and T2-FLAIR sequence showed hyperintensities of bilateral cerebellum. T2-FLAIR hyperintensities of bilateral dorsomedial thalami, fornix, and post-contrast-enhancement of mammillary bodies were also noted. The clinical picture with imaging findings was concerning for possible thiamine deficiency. In Wernicke’s encephalopathy, restricted diffusion, T2-FLAIR hyperintensities, and contrast enhancement may be seen in mammillary bodies, dorsomedial thalami, tectal plate, periaqueductal grey matter, and rarely in the cerebellum as well. Her thiamine level was 70 nmol/l (reference range: 70–180 nmol/l). Thiamine levels can be falsely elevated in patients who are on enteral feeds, which was the case in our patient. She was started on high dose thiamine replacement. At time of discharge, repeat MRI brain revealed resolution of cerebellar changes with mild atrophy and patient had subtle neurological improvement including consistent eye opening, tracking, and attending to examiner, as well as mumbling words.
Development of Learning Devices Using the Missouri Mathematics Project (MMP) Model on Statistical Materials in Junior High Schools
Authors: Tessa Lestari  , Abdurrahman
Published: November 2022

This development research aims to produce learning device products using a valid Missouri Mathematics Project (MMP) model. The learning device products developed to consist of the Learning Implementation Plan (RPP) and Student Worksheets (LKPD). This type of research is development research with the ADDIE model, which has been modified into four stages (Analysis, Design, Development, and Evaluation). The data collection instruments used in this study were validation sheets and teacher response sheets to measure the validity and practicality of learning devices. The data analysis used is descriptive data analysis which describes the level of validity and practicality of the product. The data was obtained from the validation results by two mathematics education lecturers and two mathematics education teachers. The results obtained in the form of RPP validation results are 83.33% with valid criteria, and LKPD validation results are 87.88% with very valid criteria, then the results of the practicality questionnaire for practical RPP with an average of 83.33% and LKPD in the category very practical with an average of 87.5%. Thus, it can be concluded that this development research resulted in learning tools (RPP and LKPD) that were tested for their validity and practicality.
Prospects of Using Apartments for Tourism Development in St. Petersburg
Authors: Танина Анна Валерьевна
Published: November 2022

В данной статье раскрываются особенности использования апартаментов как объектов инфраструктуры туризма в Санкт-Петербурге. На основе обзора рынка средств размещения оцениваются перспективы использования апартаментов для развития туризма в регионе. Выделены виды апартаментов, определены перспективные направления развития инфраструктуры комплексов апартаментов.

We reveal the characteristics of using apartments as objects of tourism infrastructure in St. Petersburg. Based on the review of accommodation facilities market we estimate the prospects of using apartments for tourism development in the region. Types of apartments are classified, promising areas for apartment infrastructure development are defined.
Management of Innovation Development of Corporate Structures to Secure their Competitive Ability
Authors: Стародубов Денис Олегович , Макаров Владимир Васильевич
Published: November 2022

Исследуются основные методические подходы к управлению инновационным развитием корпоративных структур, сравниваются их преимущества и недостатки. На примере зарубежных рынков инноваций анализируются различные объекты инновационной инфраструктуры, рассматриваются их специфические особенности. Отмечается, что в России проходит этап качественного формирования национальной инновационной системы. Поэтому на данном этапе необходимо создавать и поддерживать на государственном уровне экономические и организационные стимулы инновационного развития корпоративных структур, обеспечивающих их стратегическую устойчивость и конкурентоспособность.

We research the key method approaches to managing innovation development of corporate structures and compare their advantages and disadvantages. By the example of foreign markets of innovations, we analyze various objects of innovation infrastructure and look at their specific characteristics. We note that Russia is now facing the quality formation of national innovation system. Thus, we currently need to create and support at the government level economic and organization incentives for innovation development of corporate structures securing their strategic sustainability and competitive ability.
Voenmeh and Its People in Great Patriotic War
Authors: Бородавкин Вячеслав Александрович , Иванов Константин Михайлович , Охочинский Михаил Никитин
Published: November 2022

Рассматривается участие Ленинградского военно-механического института (ЛВМИ), его сотрудников и студентов в Великой Отечественной войне 1941-1945 гг. Показана роль ЛВМИ как школы конструкторских кадров в области разработки артиллерийского и стрелкового вооружения, создававших оружие Победы в предвоенные и военные годы. Рассказано о судьбах фронтовиков, связавших свою деятельность с созданием ракетно-космической техники и подготовкой кадров для оборонной промышленности Советского Союза в послевоенные годы.

We consider the role of Leningrad Military-Mechanical Institute, its personnel and students in the Great Patriotic War of 1941-1945. We tell about the institute as a school for preparing the developers of artillery equipment and weapons who contributed to the Great Victory. We also tell the biographies of veterans who devoted themselves to making space-rocket hardware and training staff for Soviet defense industry in the post-war period.
Detection of Pyridine Derivatives by SABRE Hyperpolarization at Zero Field
Authors: Put Piotr , Alcicek Seyma , Bondar Oksana , Bodek Łukasz , Duckett Simon , Pustelny Szymon
Published: November 2022

Zero-field nuclear magnetic resonance (NMR) recently emerged as an interesting new analytical modality. While zero-field NMR provides new capabilities, it also suffers from some limitations associated, to a great degree, with low signal amplitude. In this context, parahydrogen-induced polarization naturally complements zero-field NMR, as this hyperpolarization is active even at zero magnetic field. In turn, the efficient production of large non-equilibrium polarization is possible in zero field, boosting the signal amplitude and enabling realization of the concept of "NMR without magnets''. In this work, we present zero-field NMR studies of various hyperpolarized pyridine derivatives where the 15N isotope is present at a natural abundance (0.36%). By comparing the signals of these pyridine derivatives, which include vitamin B3, as a function of their substituents, we demonstrate unique zero-field NMR spectra, consequently establishing how chemical analysis is possible even in zero field. We also study the effect of the parahydrogen-polarization-transfer catalyst activation on the resulting hyperpolarization dynamics. All of these measurements were made using apparatus designed to allow repeated in situ hyperpolarization of these samples without affecting their composition.
Critical assessment of synthetic accessibility scores in computer-assisted synthesis planning.
Authors: Skoraczyński Grzegorz , Kitlas Mateusz , Miasojedow Błażej , Gambin Anna
Published: November 2022

Modern computer-assisted synthesis planning tools provide strong support for this problem. However, they are still limited by computational complexity. This limitation may be overcome by scoring the synthetic accessibility as a pre-retrosynthesis heuristic. A wide range of machine learning scoring approaches is available, however, their applicability and correctness were studied to a limited extent. Moreover, there is a lack of critical assessment of synthetic accessibility scores with common test conditions. In the present work, we assess if synthetic accessibility scores can reliably predict the outcomes of retrosynthesis planning. Using a specially prepared compounds database, we examine the outcomes of the retrosynthetic tool AiZynthFinder. We test whether synthetic accessibility scores: SAscore, SYBA, SCScore, and RAscore accurately predict the results of retrosynthesis planning. Furthermore, we investigate if synthetic accessibility scores can speed up retrosynthesis planning by better prioritizing explored partial synthetic routes and thus reducing the size of the search space. For that purpose, we analyze the AiZynthFinder partial solutions search trees, their structure, and complexity parameters, such as the number of nodes, or treewidth. We confirm that synthetic accessibility scores in most cases well discriminate feasible molecules from infeasible ones and can be potential boosters of retrosynthesis planning tools. Moreover, we show the current challenges of designing computer-assisted synthesis planning tools. We conclude that hybrid machine learning and human intuition-based synthetic accessibility scores can efficiently boost the effectiveness of computer-assisted retrosynthesis planning, however, they need to be carefully crafted for retrosynthesis planning algorithms. The source code of this work is publicly available at https://github.com/grzsko/ASAP.
Metabolically associated fatty liver disease – a disease of the 21st century: A review
Authors: Maev Igor V. , Andreev Dmitry N. , Kucheryavyy Yury A.
Published: November 2022

Metabolically associated fatty liver disease (MAFLD) is a widespread chronic disease characterized by increased accumulation of fat in the liver, which is based on metabolic dysfunction. The incidence of MAFLD is well over 20% in most regions of the world and is on an increasing trend. Current thinking considers the etiology and pathogenesis of MAFLD under the concept of "multiple parallel blows". According to this model, the development and progression of the disease are due to the interaction of multiple genetic, environmental and adaptive factors, which include specific genetic polymorphisms (e.g., the PNPLA3 gene) and epigenetic modifications, dietary patterns (e.g. high saturated fat and fructose intake), sedentary activity, obesity, insulin resistance, dysregulation of adipokines, lipotoxicity, oxidative stress, and gut microbiota dysbiosis (small intestinal bacterial overgrowth syndrome). The basis for the diagnosis of MAFLD is the presence of proven hepatic steatosis in combination with one of the following criteria: overweight/obesity, presence of type 2 diabetes mellitus, signs of metabolic dysregulation. Nonmedicamental therapies recommended for patients with MAFLD include weight loss (if overweight or obese), reduction of saturated fatty acid and fructose intake, and inclusion of adequate amounts of omega-3 polyunsaturated fatty acids and dietary fibre (psyllium) in the diet. Pharmacotherapy of MAFLD should be aimed at correcting insulin resistance, improving liver function and reducing the risk of associated diseases.
Jaundice as an atypical manifestation of the new coronavirus infection. Case report
Authors: Pichugina Irina M. , Ogoltsova Irina M.
Published: November 2022

In many cases, the clinical presentation of SARS-CoV-2, seeking to the epithelium of the respiratory tract, was typical and affected only the respiratory system, but if we look at the statistics, other clinical findings were also encountered. In particular, the virus can also affect the gastrointestinal tract. There was an outbreak of SARS in 2002, and more than 70% of patients had dyspeptic disorders. In 2012, there was an outbreak of the Middle East respiratory syndrome and a quarter of patients had similar symptoms. And there were cases in which it was dyspepsic phenomena that came to the forefront and respiratory phenomena only afterwards. Already in 2012, this behavior of coronavirus made it difficult to make a correct diagnosis. SARS-CoV (2002), MERS-CoV (2012), and the new SARS-CoV-2 (2019) belong to the genus Betacoronavirus, and the genome sequence of SARS-CoV-2 is similar at 82% to that of severe acute respiratory syndrome coronavirus. The kinship of the viruses should alert physicians and always warn that an atypical clinical picture of the disease is possible, as has been the case in the past. This article describes a clinically interesting patient. Jaundice is the only symptom, a symptom that confuses doctors, because no one could think of a coronavirus infection in this case. The purpose of this article is to show on the example of a patient that it is difficult to diagnose the main diagnosis in case of atypical symptomatology of COVID-19. Therefore, also in cases of liver damage it is necessary to collect the anamnesis qualitatively, to make differential diagnosis not only within the framework of gastroenterology, but also in present conditions suspecting a new coronavirus infection.
Phenotypes of gastroesophageal reflux disease: classification, pathogenesis and diagnostic criteria: A review
Authors: Maev Igor V. , Barkalova Elena V. , Ovsepian Mariia A. , Andreev Dmitry N.
Published: November 2022

The literature review focuses on the current understanding of visceral hypersensitivity mechanisms in the esophagus. Mechanisms of peripheral and central sensitization and their relation to heartburn symptoms are covered in detail. Diagnostic criteria and algorithms for non-erosive reflux disease, functional heartburn, and esophagus hypersensitivity based on pH-impedance testing and high-resolution esophageal manometry data are presented.
Prevention and treatment of some gastrointestinal complications after bariatric surgery: A review
Authors: Ilchishina Tatiana A. , Kucheryavyy Yury A. , Sviridova Tatiana N.
Published: November 2022

Globally, the incidence of overweight is increasing every year, and doctors around the world are talking about an epidemic of obesity. There has been a significant increase in bariatric surgery procedures as the only effective approach for morbid obesity. However, as the indications for bariatric surgery expand and the number of procedures increases, the number of publications on perioperative, postoperative, and late complications of surgery naturally increases.
Changes in the organs and tissues of the oral cavity in the new coronavirus infection (COVID-19): A review
Authors: Trukhan Dmitry I. , Sulimov Anatoly F. , Trukhan Larissa Yu.
Published: November 2022

SARS-CoV-2 infection can cause changes in the organs and tissues of the oral cavity, which is associated with a wide distribution of angiotensin-converting enzyme type 2 in the oral cavity, mainly epithelial cells of the oral mucosa, gums and fibroblasts of the periodontal ligament. Thus, the oral mucosa is susceptible to SARS-CoV-2 infection and may act as a gateway for the virus, as well as a reservoir for SARS-CoV-2. We searched the literature for the period from the beginning of the pandemic until May 30, 2022, devoted to the study of changes in the organs and tissues of the oral cavity with a new coronavirus infection (COVID-19) in the electronic search engines PubMed/MEDLINE and Scopus. A special place in the study of changes in the organs and tissues of the oral cavity with a new coronavirus infection (COVID-19) is occupied by periodontal pathology. A number of reviews and clinical studies conclude the importance of good oral hygiene and periodontal health as an important aspect of COVID-19 prevention and management. Oral probiotics can be considered as a promising direction for correcting changes in organs and tissues of the oral cavity in COVID-19.
Visceral sensitivity index of patients with irritable bowel syndrome after COVID-19 infection
Authors: Feklina Iana Yu. , Mnatsakanyan Marina G. , Pogromov Alexander P. , Tashchyаn Olga V.
Published: November 2022

Aim. To perform comparative analysis of visceral sensitivity index (VSI) of patients with previously diagnosed irritable bowel syndrome (IBS) and of patients with IBS symptoms after COVID-19 infection.
Materials and methods. The study was carried out on the basis of University Clinical Hospital №1; 200 patients with COVID-19 infection were examined. Selection criteria were the recommendations of the Rome Consensus IV (2016). Fourteen patients met the criteria for IBS (Rome IV). Forty patients with a verified diagnosis of IBS before the COVID-19 pandemic (Group 2) were selected as a comparison group. The control group included 50 healthy respondents (group 3). Group 1 included 14 patients; Group 2 included 40 patients (54 patients in total): 37 women and 17 men. The control group included 50 patients: 23 men and 27 women. VSI was estimated in the studied groups.
Results. No statistically significant difference of VSI index (p0.05) was revealed while comparing two studied groups (group 1 and group 2). In group 1 and group 2 the mean values of VSI were 24.575.47 and 33.982.55 respectively. Absence of significant differences allows to assume from the position of biopsychosocial model that the patients were initially predisposed to IBS development.
Conclusion. A new coronavirus infection is one of the triggers for the development of IBS 6 months after COVID-19 infection.
Effectiveness of Rebamipide as a part of the Helicobacter pylori eradication therapy in Russia: a meta-analysis of controlled trials
Authors: Andreev Dmitry N. , Maev Igor V. , Bordin Dmitry S. , Lyamina Svetlana V. , Dicheva Diana T. , Fomenko Aleksei K. , Bagdasarian Armine S.
Published: November 2022

Aim. To perform a meta-analysis of the data on Rebamipide efficacy and safety as a part of Helicobacter pylori eradication therapy in Russian patients.
Materials and methods. A search for original studies was conducted in the electronic database of the Russian Science Citation Index (RSCI) on the Scientific Electronic Library (SEL Elibrary.ru). Google (Google.com) was used for the "grey" search. All Russian controlled studies comparing the efficacy and/or safety of Rebamipide as a part of the regimen of H. pylori eradication therapy were included in the final analysis.
Results. In 6 included controlled trials with a cumulative population (considering double comparisons between multiple groups) of 531 patients (273 in Rebamipide groups and 258 in groups without Rebamipide), the pooled eradication effectiveness was 90.376% (95% confidence interval CI 86.31193.560) in patients receiving Rebamipide and 81.681% (95% CI 76.49986.141) in patients receiving eradication regimens without Rebamipide. The meta-analysis showed that the Rebamipide addition to eradication regimens significantly improved efficacy (odds ratio 2.162, 95% CI 1.2683.685; p=0.005). No significant heterogeneity was found between study results (p=0.863; I2=0.00%); therefore, a fixed effects model was used in the resulting analysis. In addition, the meta-analysis of included studies showed a reduction of adverse events (odds ratio 0.569, 95% CI 0.3330.970) in the groups receiving Rebamipide; p=0.038). This effect of Rebamipide deserves special attention and requires additional study, as the result was at the border of statistical significance in the subanalysis of three studies with a large margin of risk reduction in one of them (with the largest sample of patients).
Conclusion. The present meta-analysis demonstrated that the Rebamipide addition to H. pylori eradication regimens significantly improves the treatment effectiveness in the Russian patient population.
C-to-U RNA deamination is the driving force accelerating SARS-CoV-2 evolution
Authors: Li Yan , Hou Fanghua , Zhou Meili , Yang Xiaoping , Yin Bin , Jiang Wenqing , Xu Huiqing
Published: November 2022

Understanding the molecular mechanism underlying the rampant mutation of SARS-CoV-2 would help us control the COVID-19 pandemic. The APOBEC-mediated C-to-U deamination is a major mutation type in the SARS-CoV-2 genome. However, it is unclear whether the novel mutation rateuis higher for C-to-U than for other mutation types, and what the detailed driving force is. By analyzing the time course SARS-CoV-2 global population data, we found that C-to-U has the highest novel mutation rateuamong all mutation types and that thisuis still increasing with time (du/dt> 0). Novel C-to-U events, rather than other mutation types, have a preference over particular genomic regions. A less local RNA structure is correlated with a high novel C-to-U mutation rate. A cascade model nicely explains the du/dt> 0 for C-to-U deamination. In SARS-CoV-2, the RNA structure serves as the molecular basis of the extremely high and continuously accelerating C-to-U deamination rate. This mechanism is the driving force of the mutation, adaptation, and evolution of SARS-CoV-2. Our findings help us understand the dynamic evolution of the virus mutation rate.
Lack of peroxisomal catalase affects heat shock response inCaenorhabditis elegans
Authors: Musa Marina , Dionisio Pedro A , Casqueiro Ricardo , Milosevic Ira , Raimundo Nuno , Krisko Anita
Published: November 2022

Exact mechanisms of heat shock–induced lifespan extension, although documented across species, are still not well understood. Here, we show that fully functional peroxisomes, specifically peroxisomal catalase, are needed for the activation of canonical heat shock response and heat-induced hormesis inCaenorhabditis elegans. Although during heat shock, the HSP-70 chaperone is strongly up-regulated in the WT and in the absence of peroxisomal catalase (ctl-2(ua90)II), the small heat shock proteins display modestly increased expression in the mutant. Nuclear foci formation of HSF-1 is reduced in thectl-2(ua90)IImutant. In addition, heat-induced lifespan extension, observed in the WT, is absent in thectl-2(ua90)IIstrain. Activation of the antioxidant response and pentose phosphate pathway are the most prominent changes observed during heat shock in the WT worm but not in thectl-2(ua90)IImutant. Involvement of peroxisomes in the cell-wide cellular response to transient heat shock reported here gives new insight into the role of organelle communication in the organism’s stress response.
Exploratory study: the impact of implementing “you and me” sexual education program in the family
Authors: Rakhmawati Ellya , Aditya Dita Permata , Yunita Adhitya Riska , Markiewicz Inga
Published: November 2022

In recent years, there was news about sexual violence experienced in early childhood. Sexual violence becomes public health issue in many countries, which has negative consequences for the victims. The impact of sexual violence can affect children psychologically, physically, psychosocially, and etc. The study aims to determine the impact of implementing the sexual education “You and Me” program in the family. Rutgers WPF and PKBI Central Java have provided the “You and Me” program since 2017, but the several schools have adjusted the implementation of sexual education based on the learning theme. This study used the qualitative descriptive approach method. The research subjects consist of 5 participants of parents who have children at the age of 2-6. Data analysis techniques are carried out into four stages: data reduction, descriptive data presentation, data classification or coding categorization, and concluding. The result stated that the impact of the sexual education “You and Me” program on children has various effects and aligns with sexual education. Therefore, it can be concluded that the application of sexual education from five participants is quite effective. The results showed that the participants had a positive impact on children's behavior and thoughts while delivering sexual education. Although not all participants told their experiences in applying sexual education, most of them showed the positive impact of the children’s behaviour and thoughts.
The role of alphabet book in improving preschool children’s letter recognition
Authors: Syam Nurbaeti , Afiif Ahmad , Damayanti Eka
Published: November 2022

Letter recognition is the first stage in developing children’s reading skills. It is hence important to optimize the stimulus for letter recognition, either in terms of methods or media. One of the media helpful for improving children’s letter recognition is the alphabet book. The present study aims to depict the role of the alphabet book in improving preschool children's letter recognition. This qualitative library research garnered articles and books using two keywords: alphabet book and letter recognition. The data were collected using documentation and analyzed using Miles and Huberman’s descriptive analysis. The result showed that Alphabet Book improved children’s letter recognition. Alphabet book could improve children’s ability to recognize letter shapes and sounds and write the letter. This improvement appears to be accounted for by the book’s various themes, attractive illustrations, and words representing each letter. The alphabet book is also interesting when used together with storytelling and play methods. Alphabet book also plays a role in improving children's learning interest and enriching their vocabulary.
Upaya Peningkatan Pengetahuan dan Keterampilan Siswi Melalui Pelatihan Pemeriksaan Payudara Sendiri (SADARI) di SMPN 4 Kota Cirebon Tahun 2019
Authors: Yuhandini Diyah Sri , Jubaedah Entin
Published: November 2022

Penyakit kanker merupakan masalah kesehatan utama baik di dunia maupun di Indonesia. Kanker payudara dapat ditemukan secara dini dengan Pemeriksaan Payudara Sendiri (SADARI). Walaupun pemeriksaan SADARI ini merupakan cara yang termudah dan efektif tetapi kenyataannya pada saat ini  masih banyak remaja Indonesia yang belum mengetahui tentang SADARI. Materi diberikan pada perwakilan siswi kelas VII A dan sisiwi kelas VII B yang sudah mengalami menstruasi sebanyak 26 orang. Dengan cara ceramah dan tanya jawab, sebelumnya diberikan pretest untuk mengetahui informasi terkait tentang SADARI, dilanjutkan dengan demonstrasi SADARI dengan menggunakan phantom. Dan setelah kegiatan dilakukan posttest. Rata-rata pengetahuan siswi pada pre test adalah 10,92 dan post test adalah 7,96. Peningkatan rata-rata pre test pengetahuan adalah 7,04. Rata-rata keterampilan siswi pada pre test adalah 0,00 dan post test adalah 89,58. Peningkatan rata-rata keterampilan adalah 89,58. Terdapat peningkatan pengetahuan dan keterampilan siswi tentang SADARI dan cara melakukan SADARI. Sekolah diharapkan dapat memfasilitasi siswi untuk transfer informasi SADARI ke siswi lain dan dapat meningkatkan kerjasama dengan puskesmas wilayah setempat dalam promosi kesehatan sehingga kesehatan reproduksi remaja meningkat.
Pemberdayaan Kader Desa Sidosari Dalam Pencegahan Stunting Melalui Pendekatan Kolaborasi Inter-Profesional Kecamatan Natar Lampung Selatan
Authors: Isnenia Isnenia , Putri Sefanadia , Khoiriyah Yustin Nur
Published: November 2022

Kejadian stunting merupakan proses kumulatif sejak sebelum kehamilan hingga 1000 hari pertama kehidupan yang akan berdampak pada tumbuh kembang anak. Kondisi gizi wanita subur (didorong untuk menurunkan anemia) dan ibu hamil, ibu menyusui, serta kesehatan bayi sampai dengan usia 2 tahun dapat sebagai sasaran pencegahan stunting. Tiga hal yang perlu diperhatikan dalam upaya pencegahan stunting, yakni perbaikan pola makan, pola asuh, serta perbaikan sanitasi dan akses air bersih. Pelaksanaan ketiga upaya ini dapat melibatkan beberapa disiplin ilmu, yaitu gizi mengenai pola makan yang tepat, biologi terkait dengan buruknya sanitasi dan infeksi bakteri/parasit, serta farmasi terkait dengan penggunaan obat yang tepat dalam mengatasi infeksi/penyakit lain terkait dalam pencegahan stunting. Kegiatan ini terdiri dari penyuluhan terhadap masyarakat (wanita usia subur, ibu hamil/ menyusui/ibu bayi-balita), pelatihan dan pendampingan kader melalui focus group discussion dan praktik langsung mengenai pola makan, penggunaan obat, dan parasit/bakteri penyebab infeksi. Hasil kegiatan penyuluhan adanya peningkatan pengetahuan warga sebesar 50% dan 86,67% warga memiliki kadar Hb normal. Kader dan warga 100% mampu menyusun isi piring dengan tepat. Peningkatan persentase  jumlah kader dan warga  dalam mengidentifikasi pengunaan obat yang tepat lebih dari 50%. Peningkatan persentase jumlah kader dan warga yang sebelumnya tidak tahu menjadi tahu mengenai jenis parasit dan penanganannya lebih dari 60%.
Pemberdayaan Kader Posbindu di Wilayah Kerja Puskesmas Negara Ratu Dalam Pencegahan Penyakit Tidak Menular yang Dapat Memperberat COVID-19
Authors: Apriyani Heni , Taufiq Ihsan , Sono Sono , Hasan Amrul
Published: November 2022

Indonesia menghadapi beban ganda penyakit, yaitu penyakit menular dan penyakit tidak menular. Prevalensi Penyakit Tidak Menular (PTM) terus meningkat dan pada tahun 2016 berkontribusi pada 73% dari seluruh kematian di Indonesia. Prevalensi penyakit jantung berdasarkan hasil Riskesdas tahun 2013 dan 2018 menunjukkan bahwa prevalensi penyakit jantung koroner berdasarkan diagnosis dan gejala sebesar 1,5%. Berdasarkan profil Puskesmas Negara Ratu tahun 2019 prevalensi penyakit tidak menular masuk ke dalam 10 macam penyakit tertinggi, dimana Hipertensi menempati urutan 5 sedangkan Diabetes Mellitus pada urutan ke 10. Kondisi ini dialami di Desa Hanakau Jaya dan Desa Padang Ratu yang merupakah wilayah kerja Puskesmas tersebut. Hipertensi dan DM merupakan penyakit serius yang dapat memperberat kondisi COVID-19. Peran aktif Kader Posbindu menjadi sangat penting dalam pengendalian COVID-19 melalui deteksi dini Hipertensi dan DM. Tujuan kegiatan adalah meningkatkan pengetahuan dan keterampilan Kader Posbindu dalam pengendalian Hipertensi dan DM dikaitkan dengan COVID-19. Metode pelaksanaan melalui Pelatihan Kader Posbindu di Desa Hanakau Jaya dan Padang Ratu, Kecamatan Sungkai Utara Kabupaten Lampung Utara, berupa ceramah, diskusi dan demonstrasi, dilaksanakan pada tahun 2021. Hasil dan simpulan menunjukkan bahwa 100% Kader Posbindu memiliki pengetahuan yang baik tentang Hipertensi dan DM dikaitkan dengan COVID-19, dan memiliki keterampilan untuk mengukur Indeks Massa Tubuh, Mengukur Tekanan Darah dan Mengukur Kadar Gula Darah secara sederhana.
Effect of Mulching And Licorice Root Extract on Growth of Two Broccoli Cultivars (brassica Oleracea Var. Italica.)
Authors: Yousif Kurdistan Hassan , Saeid Abdul Jebbar Ihsan
Published: November 2022

This study was aimed to evaluate the effect of cultivars, mulching, foliar application of licorice root extract, on broccoli leaves (Brassica oleracea var. italica). The findings demonstrated that both cultivars Wisdom and Agassi have significant differences in terms of vegetative growth characters, All studied traits in both cultivars were significantly increased by the wisdom cultivar during the study seasons. It was also observed that plastic mulch significantly increased all investigated traits in both cultivars. The interactions between licorice root extract and straw were marked by the elevation of most detected traits. Black plastic mulch significantly impacted most measures, whereas 18g.L-1 and black plastic mulch together produced the greatest overall result in all vegetative growth parameters (Number of leaf. plant-1, plant high (cm), stem length (cm) , branch number. Plant-1 and chlorophyll contents (SPAD). Regarding nutrients contents, significant differences were showed. The combination among three factures was significant enhanced all studied traits
Impact of Cultivars, Planting Dates And Chicken Manners on Vegetative Growth And Yield of Onion (allium Cepa L.)
Authors: Ababaker Shireen Khudher , Mohammed Ghurbat Hassan
Published: November 2022

The study was examined the effects of three planting dates (1st October, 15th October, and 1st November) and three levels of chicken manures (0, 1000, and 1500 g.m-1) on two cultivars of onion (Texas Early white and Early white Grano) during the growth season 2021–2022 at the vegetable research farm of the Protected Cultivation Department, Zakho Technical Institute/Dohuk Polytechnic University. The results showed that there were no significant differences between two cultivars in all traits excepted the cultivar Texas was superior over cultivar Grano in number of leaves plant-1. Planting date at 1st October led to significant differences in plant length (cm), number of leaves plant-1, mean bulb weight (g), number of stored leaves bulb-1, total yield (t.ha-1), N%, P%, K% and S% in bulbs. Application chicken manures especially 1000 g.m-1 significantly increased all traits. The combination among (cultivar Texas, 1st October planting date and 1000 g.m-1 chicken manure significantly enhanced the plant length (66.14 cm), number of leaves plant-1 (18.18), mean bulb weight (328.51 g), number of stored leaves bulb-1 (13.11), total yield (38.55 t.ha-1), N% (2.64%), P% (0.432%), K% (4.32%) and S% (0.661% in bulbs
Determinants of Financial literacy and its influence on Financial Wellbeing — a study of the Young Population in Haryana, india
Authors: Sangeeta . , Aggarwal P. K. , Sangal A.
Published: November 2022

The purpose of this study —  is to determine how financial knowledge, attitudes and behaviours (determinants of financial literacy) influence an individual’s overall financial well-being.

The methodological basis of the study was a survey of 115 respondents, for which a well-structured questionnaire was developed. Smart PLS version 3 software was used to conduct the PLS analysis. The authors applied a multivariate methodology called Structural Equation Modelling (SEM) to integrate characteristics that cannot be seen directly.

It is concluded that both financial attitudes and financial behaviour affect financial well-being, with financial behaviour having a greater impact on financial well-being, while financial knowledge does not. The ultimate goal of financial literacy is to increase financial well-being among the population. The results of this study can be used by policy makers, government and educational institutions who should pay more attention to improving the very determinants of financial literacy that affect financial well-being.
Shareholder’s reaction to Merger and acquisition announcement: evidence from india’s Manufacturing sector
Authors: Gupta I. , Raman T. V.
Published: November 2022

Mergers and acquisitions performance is akin to financial perplex that researchers have been trying to solve. The objective of the study is to examine the reaction of shareholders to the announcement of mergers and acquisitions in the pre-event, around the event and during the post-event period of the Indian manufacturing firms. The event study research methodology has been used for analysis along with parametric and non-parametric tests. The study shows that investors can earn a significant return if they purchase shares of the acquiring company one day before and sell them one day after the announcement day. The findings concluded that while the announcement of a merger or acquisition generates a positive reaction, this reaction is only temporary and is swiftly diluted. This shows that investors initially overreacted to these announcements and took immediate corrective action. The study recommends to investors, “Earlier the shareholders sell, more the shareholders gains”.