bluuebunny/crossref_metadata_2025 huggingface dataset:
Solubility Enhancement and Formulation Development of an Oral Film of Ondansetron Hydrochloride Monohydrate using Mix-solvency Concept
Authors: Tomer Kirti , Kumar Saurav , Goyal Swapnil , Dwivedi Akanksha , Khabiya Rakhi , Dwivedi Sumeet
Published: January 2024

This research paper presents the formulation and evaluation of ondansetron hydrochloride monohydrate oral film using the mix-solvency concept. Ondansetron hydrochloride monohydrate a selective serotonin receptor antagonist is commonly prescribed to prevent chemotherapy or surgery-induced nausea and vomiting. The aim of the study was to enhance the solubility of ondansetron hydrochloride monohydrate which has been enhanced by the blend of varying aqueous solubilizers poly ethylene glycol, niacinamide, and caffeine. The oral film formulation was prepared using a solvent casting method, incorporating polymers, plasticizers and different solvents. Various formulation variables, including solvent type and concentration, polymer-to-plasticizer ratios, and drug loading, were optimized systematically the resulting oral film was investigated for various parameters such as thickness, drug content, disintegration time, folding endurance and surface pH. The % in-vitro release of drug of the best two formulations F3 and F5 was 99.70 and 96.62%, respectively.
Enhanced Solubility and Dissolution Rate of Aceclofenac using Freeze Drying Technique
Authors: Nikam Vikrant , Somwanshi Sachin , Kashid Vivekanand , Kotade Kiran , Shete Shubham , Patil Kapil
Published: January 2024

The purpose of this investigation was to determine whether lyophilization or freeze-drying Aceclofenac could improve the solubility of the medicine, making it more easily dissolved into tablets. The drug aceclofenac is classified as a biopharmaceutical classification system (BCS) class II medicine. The lyophilization process was facilitated by the addition of SLS as an adjuvant, which has the potential to enhance the dissolving rate. Aceclofenac was swiftly released from fast-dissolving tablets by including an appropriate ratio of PVP K-30. Aceclofenac from a lyophilized sample dissolved at a much faster pace than plain aceclofenac in-vitro. The amount of polymer had an effect on the dissolving rate. The dissolving efficiency of the drug and polymer is enhanced at a 1:2 ratio. Therefore, aceclofenac can be effectively dissolved using the lyophilization procedure.
Exploring the Antioxidant Potential of Cissus woodrowii (Stapf Ex Cooke) Santapau: A Study on Leaves and Stem
Authors: Patil Pallavi N , Singh Santosh K , Wadkar Kiran A
Published: January 2024

Cancer, diabetes mellitus, cardiovascular disease, neurodegenerative illness, inflammatory disease, and many other pathologies have a common denominator: oxidative stress. The situation arises from the overproduction or ineffective quenching of free oxygen and nitrogen species within the cell. Antioxidant activity, nutritional value and traditionally roots were made into a powder and applied to cut wounds where pus had formed, ethnobotanical/traditional use is as an antitumor in Maharashtra. Owing to its ethnomedicinal importance, proper identification with pharmacognostic and phytochemical details and evaluation is vital for drug development and to prevent adulteration highlights and their role in laying down standardization. The present paper discusses phytochemical and antioxidant study of Cissus woodrowii (Stapf ex Cooke) Santapau. The both extract showed occurrence of glycosides, phenolic compounds, alkaloids, flavonoids also tannin and aqueous and ethanol extract of stem and leaves showed good antioxidant properties by DPPH assay.
Chronopharmacokinetic and Metabolites Investigations of the Cardiovascular Drugs Perindopril
Authors: Umarkar Arvind , Panda Subhranshu , Suryavanshi Hemant
Published: January 2024

The heart and vascular systems are well-coordinated. There is a noticeable uneven distribution of regulatory mechanisms and pathogenic events over the course of a day. In addition, the physiological circadian clock of the cardiovascular system might be disrupted by several disorders. In terms of global mortality and morbidity, heart failure (HF) ranks high. The angiotensin receptor-neprilysin inhibitor perindopril is now a valid option for treating heart failure. There is a lack of comprehensive evaluations of perindopril’s safety and effectiveness in HF at the present time. First, we provided an overview of perindopril’s pharmacological actions, which include inhibiting the renin-angiotensin system and decreasing natriuretic peptide breakdown in the natriuretic peptide system. After that, we summed up the benefits of perindopril for heart failure patients with preserved ejection fraction (HFpEF) or reduced ejection fraction (HFrEF), such as lowering the risk of death and hospitalization, reversing cardiac remodeling, regulating biomarkers of heart failure, improving quality of life, providing antiarrhythmic effects, enhancing renal dysfunction, and regulating metabolism. Our discussion of perindopril’s safety and tolerability in treating HFrEF or HFpEF came to a close. Although there is a considerable risk of hypotension, perindopril demonstrated superior safety and tolerability when compared with placebo. For HFrEF patients, perindopril is a safe and effective therapy option, however, for HFpEF patients, it shows little benefit, according to the majority of studies. Soon, perindopril will likely be one of the most effective drugs available to treat heart failure.
In-silico Design and Development of Multi-Target Agents Targeting Glycogen Synthase Kinase-3 Beta and Vascular Endothelial Growth Factor Receptor 2 for Acute Myeloid Leukemia
Authors: Gaikwad Asmita , Kayande Nandu , Tare Harshal , Udugade Babaso , Kachave Ramanlal
Published: January 2024

This research focuses on the in-silico design of multi-target agents for acute myeloid leukemia (AML), targeting GSK-3β and VEGFR2. Using TTD data, we selected a promising target pair and considered 20,818 agents. Ligand-based screening in ChEMBL identified compounds with diverse structures and favorable interactions. Protein structures (GSK-3β: PDB ID 1Q5K, VEGFR2: PDB ID 3QTK) underwent rigorous quality assessment, indicating high-quality models. Molecular docking revealed varied affinities, with CHEMBL183504 showing strong affinity for GSK-3β in pocket C1, and CHEMBL185922 for VEGFR2 in pocket 2. CHEMBL181959 exhibited dual affinity. Further experimental validation is needed. In conclusion, this study provides insights for AML therapy, guiding compound selection and structural quality assessment for potential drug development
Designing, Creating, and Assessing a Modified Pulsincap Delivery System for Intestine Targeting of Fluvastatin in Accordance with Circadian Rhythm
Authors: Mahesh M , Jayakumari S
Published: January 2024

The current study’s objective remains to create the Pulscap delivery system using an insoluble capsule core that contains fluvastatin sodium microspheres. Eudragit RL 100 polymer fluvastatin sodium microspheres were made using the solvent evaporation method. To reduce the possibility of stomach upset, these microspheres were hand-filled into capsules, plugged with hydrogel plugs, then sealed with ethyl cellulose acetate and dipped in an eight: two (vol/vol) Acetone: ethanol solution by butyl pthalate of (0.75%) and 5% cellulose acetate phthalate solution. Formulated dosage form was assessed for in-vivo X-ray imaging studies, in-vitro drug release studies, and in-vivo imaging studies, pharmacokinetic study of the optimized formulation was conducted in a two-way cross-over design with 6 rabbits in each group and the pharmacokinetic parameters (Cmax, Ka, Ke, MRT and AUC0-α) are measured. A Pharmacodynamics study was also performed on lipid profiles in six groups of rabbits. Optimized formulation (F20) which is prepared with a drug and polymer ratio of 1:3, is selected based on a dissolution study which shows a percentage release of 99.98. ± 0.12% at 17th hour. In the in-vivo study, the plasma concentration at 12th hour 53.8 ± 0.02% and at 32nd hour 13.9 ± 0.05%. Pharmacokinetic parameter Cmax (ng/mL): 53.8 ± 0.41, MRT (h): 20.0 ± 0.14, t1/2 (h): 8.52 ± 0.014, Kel (h-1) :0.08 ± 0.014, Ka (h-1):0.25 ± 0.02, AUC0-a (ng h/mL): 944.9. ± 4.05. Serum lipid profile in high cholesterol rabbit after treatment with F20 formulation total cholesterol:240.83 ± 19.76, HDL-C:37.33 ± 2.16, triglycerides:318.67 ± 7.74, VLDL-C:63.73 ± 1.55, LDL-C:139.77 ± 18.74. Compared to lovastatin SR release, lovastatin pulsatile release, and fluvastatin SR release, the results imply that the F20 formulation’s pulsatile drug delivery has established good drug delivery for medications entering the gastrointestinal tract, and it displays superior pharmacokinetic and pharmacodynamic parameters.
Formulation of Herbal Topical Dermatological Dosage Form by Quality by Design Approach
Authors: Tiple Rupali H , Jamane Shamli R , Khobragade Deepak S , Mundhada Dharmendra R
Published: January 2024

Objective: The study developed an optimized dosage form by quality by design (QbD) approach containing Azadirachta indica (Neem) leaf extract and a combination of selected herbal oils viz. A. indica oil, Eucalyptus citriodora oil and Cymbopogon martini oil and assessed for its antifungal efficacy, stability and dermal safety. Methods: Ointment was prepared using the fusion method from an extract of neem leaves with a combination of herbal oils viz. A. indica, E. citriodora, C. martini, bees wax and soft-paraffin. Utilizing the Box-Behnken Design (BBD), the variables such as the percentage of soft paraffin, beeswax and melting temperature were optimized in relation to the output variables such as viscosity, spreadability, and finally the antifungal efficacy, which was further quantified. Wistar albino rats were used (n = 5/test, positive and negative control) to evaluate the acute dermal toxicity test of the formulated ointment. Stability studies were assessed at 25 ± 2℃/ 60 ± 5% RH and 40 ± 2℃/ 75 ± 5% RH. Results: Melting point and percentage of beeswax significantly affect viscosity and spreadability. Optimal viscosity was obtained at 5.4% beeswax and 89.6% soft-paraffin when melted at 58℃. No dermal toxicity was observed by the ointment when comparable to petroleum jelly, both differed significantly with negative control. The absence of new spots on chromatograms, a prominent zone on agar plates, and negligible changes in spreadability (p = 0.112) all suggested physical stability, chemical stability, and antifungal efficacy, respectively. Conclusion: Neem leaf extract and a blend of selected herbal oils; A. indica, E. citrodora, and C. martini, when combined to formulate ointment, proved reliable and stable dosage form with significant anti-fungal efficacy. The formulated ointment might be helpful tool for dermatophytes management.
Cubosomes: Recent Developments and Applications from a Global Perspective
Authors: Mishra Rakesh , Aher Akash , Nandgude Tanaji , More Keshav , Kolsure Anuja
Published: January 2024

Liquid crystalline cubosomes are self-assembly of aqueous lipid and surfactant mixture. They are discrete and sub-micron in size. It is an innovative lipid-based nanosystem resembling well-known vesicular systems including niosomes and liposomes. Cubic phases incorporate lipophobic, amphiphilic and hydrophilic, components through the utilization of a rounded bi-continuous lipid bilayer and water channels. Cubosomes contain lipids such as phytantriol (PHYT) and glycerol monooleate (GMO) which are amphiphilic in nature that are diffused in water and structured in 3-D as a “honeycomb” structure with suitable stabilizer (Poloxamer 407). Cubosomes are generated by mostly two techniques i.e., top-down, bottom-up methods. UV spectrophotometer, X-ray scattering, transmission electron microscopy, and photon correlation spectroscopy are used to characterize and evaluate cubosomes. They are commonly used in the administration of oral, ophthalmic, transdermal, and chemotherapeutic drugs. The liquid crystalline phase and bicontinuous cubic form nanoparticles are thoroughly discussed in this paper. In the current review search criterion used parameters affecting cubosomes bi-continuous lipid bilayer by top-down and bottom-up methods mostly. The sources referred from peer-reviewed recognized journals. Keywords used as filters were cubosomes, amphiphilic lipids, top-down, bottom-up, bicontinuous, GMO, and phytantriol (PHYT). For the purpose of a comprehensive update literature review over a range (1976–2023) has been conducted on the recent developments cubosomes system.
Therapeutic Implementation for Hyperpigmentation and Anti-aging: A Cosmeceutical Approach
Authors: Panda Jajnadatta , Pal Abhisek , Panda Pritipadma , Panigrahy Archana
Published: January 2024

Nowadays the most preferred substance to glow skin surface by cosmeceutical products for the aged population and hyperpigmentation cases. These type of skin queries are seen in different environmental conditions including pollution, and radiation. The skin care industries are developing cosmetic products by using natural and synthetic ingredients which is biodegradable and compatible with the skin layer. Cosmetic products currently show drug-like profits because it contain vitamins, antioxidants, essential oils, phytochemical constituents, and enzymes. Cosmo-pharmaceutical products were developing rapidly to avoid skin aging or hypo/hyperpigmentation. The melanocyte or melanin is the main reason for this factor. Selecting natural extracts or resources helps to increase the therapeutic effect and reduces toxicity. The reviewer and researcher found that the term cosmeceutical, skin glowing agent, or hyperpigmentation is widely used in various treatments of melasma, and post-inflammatory hyperpigmentation. The cosmeceutical carefully preclinical and clinical evaluation studies were carried out for safety, and efficacy and no other adverse reactions were shown. Therefore the dermatologist can only provide accurate information to the patient. For the fastest growing area of research and development for a novel formulation of micro-emulsion, nano-emulsion, liposomes, niosomes, solid lipid nanoparticles and nanospheres. These nanocarriers help to incorporate into the formulation and enhance the skin permeation, high stability, and customized release properties with targeting and higher efficacy. The quality of cosmetics and cosmeceuticals is based on evidence of in-vivo and in-vitro efficacy and therapeutic effect
Ethanopharmacological Activities of Mentha arvensis: An Updated Review
Authors: . Reshu , Mazumder Avijit , Das Saumya
Published: January 2024

Economical natural menthol is derived from Mentha arvensis Linn (menthol mint) oil. It is an aromatic perennial herb. The leading Mentha producing state in area and production is Uttar Pradesh and India is the leading exporter contributing about 80% of essential oil, menthol crystal and allied products. It is a native herb from the Labiatae family and is most frequently referred to as “pudina”. It has historically been used to treat ischemic heart disease and hypertension. Terpenoids, alcohols and phenolics are just a few of the bioactive substances that have been identified from this plant. These bioactive compounds’ pharmacological activities include antibacterial, neuroprotective, antioxidant, antiulcer, immunomodulatory, antimutagenic, and anti-tumor properties. Studies on Ayurvedic, unani, and other traditional medical systems have also revealed this plant’s pharmacological capabilities. The current article provides a summary of the plant’s general description, phytochemical ingredients, historical context, and pharmacological qualities
DEVELOPMENT OF INTERACTIVE CONTENT IN WEBSITE LEARNING MEDIA TO ADDRESS STUDENT MISCONCEPTIONS ABOUT THE GREENHOUSE EFFECT
Authors: Dewi Syva Lestiyani , Kurniawan Dede Trie , Sukardi Rendi Restiana
Published: January 2024

This study addresses the pressing need to improve students' comprehension of the greenhouse effect by leveraging innovative website-based Augmented Reality (AR) learning media. The purpose is to explore the effectiveness of this media in mitigating misconceptions surrounding the greenhouse effect while providing practical solutions for educators. The research methodology combines qualitative Design and Development (D&D) approaches with quantitative measures to comprehensively evaluate the impact of AR learning media on students' understanding. Results demonstrate a significant increase of over 50% in student comprehension post-media use, validated by expert assessments and positive teacher feedback. Students reported overcoming prior misconceptions through the media's interactive approach. The study emphasizes the necessity of identifying key elements for effective AR learning, recommending comprehensive teacher training, content updates, and long-term impact assessments. The holistic approach employed unveils insights into how learning media can effectively reduce misconceptions, thereby enhancing awareness of crucial environmental issues like the greenhouse effect.
DEVELOPMENT OF A PROBLEM BASED LEARNING ORIENTED PHYSICS E-MODULE TO IMPROVE THE SCIENTIFIC LITERACY OF HIGH SCHOOL STUDENTS
Authors: Pertiwi Bella , Purwanto Andik , Setiawan Iwan
Published: January 2024

This study aims to: 1) develop a problem-based learning-oriented physics e-module to improve the science literacy of high school students, 2) determine the feasibility of the e-module, 3) determine students' perceptions of the e-module. The method used in this study is Research and Development (R&D) using the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model. However, this research was carried out limited to only the Development stage because limited research time, research costs, and adjustments to the needs of development research. The research instruments used are: 1) validation sheets of material experts, media experts, and learning design experts to find out the feasibility of the e-module being developed, 2) Student perception questionnaire to find out students' responses to the developed e-module. The results of this study showed that the results of the validation test received an average assessment of all aspects for material experts of 97.47% with very decent categories, media experts of 92.61% with very decent categories, and learning design experts of 96.52% with very decent categories and for student perception results obtained an average of all aspects of  94.23% with excellent categories. Based on the results of expert validation tests and the results of students' perceptions, it can be concluded that the products developed are decent for use as a medium for learning physics in schools.
USING PORTFOLIO ASSESSMENT TO ENHANCE STUDENTS' SCIENCE PROCESS SKILLS IN STEM LEARNING ACTIVITIES
Authors: Shidiq Galih Albarra , Bunnaen Wutthisak , Widiyan Agung Purwa
Published: January 2024

Using portfolio assessment to enhance students’ science process skills was potentially impactful in the STEM learning activities. Its benefits to navigate students gaining comprehensive experiences is necessary. The objective of this study was to examine portfolio assessment in enhancing students' science process skills in STEM learning activities. A quantitative research approach was implemented, with a sample of 33 students between the ages of 14 and 16, drawn from Indonesian public senior high schools. The instrument used to collect the data was a test. It consisted of multiple-choice and open-ended questions. The data were analyzed by using descriptive statistics. The findings reveal key indicators of science process skills in STEM learning activities, identifying portfolios that influence students' engagement and understanding within the STEM learning activities. Importantly, this study highlights the critical role of encouraging students to ask questions, as it can significantly enhance their science process skills.
Collective synthesis of highly oxygenated (furano)germacranolides from Elephantopus mollis and Elephantopus tomentosus
Authors: Patouret Rémi , Cham Ning , Chiba Shunsuke
Published: January 2024

Germacranolides, secondary metabolites produced by plants, have garnered academic and industrial interest due to their diverse and complex topology as well as a wide array of pharmacological activities. Molephantin, a highly oxygenated germacranolide isolated from medicinal plants, Elephantopus mollis and Elephantopus tomentosus, has exhibited anti-tumor, inflammatory, and leishmanicidal activities. Its chemical structure is based on a highly strained ten-membered macrocyclic backbone with an (E,Z)-dienone moiety, which is fused with an a-methylene-g-butyrolactone and adorned with four successive stereogenic centers. Herein, we report the first synthesis of molephantin via 12 steps starting from readily available building blocks. The synthesis is featured by the highly diastereoselective intermolecular Barbier allylation of the b,g-unsaturated aldehyde with optically active 3-bromomethyl-5H-furan-2-one intermediate and ensuing intramolecular Nozaki-Hiyama-Kishi (NHK) macrocyclization for the construction of the highly oxygenated ten-membered macrocyclic framework. This synthetic route enabled to craft another germacranolide congener, tomenphantopin F. Furthermore, cycloisomerization of molephantin into 2-deethoxy-2b-hydroxyphantomolin could be facilitated by irradiation with ultraviolet A light (lmax = 370 nm), which opened a versatile and concise access to the related furanogermacranolides such as EM-2, phantomolin, 2-O-demethyltomephantopin C, and tomenphantopin C.
Nickel Perfluoroalkyl Complexes Supported by Simple Acetate Co-Ligands
Authors: Ravidas Cherry , Shreiber Scott , Vicic David
Published: January 2024

The interaction of tetramethylammonium acetate with [(MeCN)2Ni(CF3)2], [(MeCN)2Ni(C2F5)2], and [NMe4][(MeCN)Ni(CF3)3] was explored by 19F NMR spectroscopy. We show that, depending on the nature of the nickel complex, one or two acetate ligands can add to the metal center and replace the nickel-bound acetonitriles, depending on the acetate concentration. The number of acetates that could bind to nickel, and whether the resulting complex exists as a monomer or dimer, was determined to be dependent on the nature of the fluoroalkyl ligand. Moreover, we observe that oxidation of the nickel center of [(MeCN)2Ni(CF3)2] in the presence of two equivalents of acetate leads cleanly to the octahedral, paramagnetic, and anionic nickel(III) complex [NMe4][(OAc)2Ni(CF3)2.
Photoinduced Luminescence Activation of Hydrophilic ‘Caged’ Carbons Dots
Authors: Akari Aviya , Narciso Maria , Fagbohun Emmanuel , Botelho Roberto , Impellizzeri Stefania
Published: January 2024

As part of our efforts to develop nanomaterials with tunable optical properties, we devised a synthetic protocol to photoactivate the luminescence of hydrophilic carbon dots by ‘caging’ the nanostructures with photocleavable 2-nitrobenzyl quenchers. Photoremovable 2-nitrobenzyl groups can be attached covalently to the surface of the carbon dots via amide-bond formation. We show that 2-nitrobenzyls efficiently quench the emission intensity of the resulting nanoconstructs and that the luminescence can be activated upon ultraviolet illumination in solution. In addition, the carbon dots can be internalized by living cells and used as bioimaging agents.
Caged Gold Nanostars: A novel plasmonic nanoplatform with theranostics applications
Authors: Canning Aidan , Vo-Dinh Tuan
Published: January 2024

Here, we first introduce caged gold nanostars (C-GNS), a novel hybrid nanoplatform combining the exceptional plasmonic properties of nanostars with the loading capability of hollow-shell structures. We present two synthetic routes used to produce C-GNS particles and highlight the benefits of the galvanic replacement-free approach. FEM simulations explore the enhanced plasmonic properties of this novel nanoparticle morphology. Finally, in a proof-of-concept study, we successfully demonstrate in vivo hyperspectral imaging and photothermal treatment of tumors in a mouse model with the C-GNS nanoplatform.
My orthopaedic surgeon suggests a unicompartmental knee replacement: a detailed look at the long-term outcomes of a single surgeon’s practice
Authors: Lynskey Samuel , Frampton Christopher , Lynskey Timothy
Published: January 2024

aim: This single surgeon case series with up to 29-year follow-up evaluated the survival of the Oxford unicompartmental knee replacement (UKR) for isolated medial compartment osteoarthritis. method: Four hundred and four knees in 330 patients were followed for between 12 days to 29 years, with an average of 13 years. Kaplan–Meier survival estimates were calculated using revision for total knee replacement and re-operation for any reason over 5-year intervals. Revision and reoperation rates per 100 component years were used to compare subsets, cemented and uncemented prostheses and Phase 2 and Phase 3 instrumentation. results: Of 404 UKRs, 292 (72%) were cemented, 96 (24%) uncemented and 16 hybrid (4%); 137 (34%) were undertaken using Phase 2 instrumentation and 267 (66%) Phase 3 instrumentation. Estimated revision-free implant survival at 20 years was 78%, and estimated reoperation-free survival at 20 years was 72%. conclusion: Unicompartmental knee replacement is a very successful procedure, with 78% of knees remaining revision-free at 20 years. Progression of lateral compartment arthritis was the most common cause for revision, affecting 60% of revision cases. There was no significant difference in the revision or reoperation rate between cemented and uncemented prostheses or Phase 2 and minimally invasive Phase 3 instrumentation.
Using electronic health records in analysing medication adherence in southern New Zealand patients with inflammatory bowel diseases
Authors: Amiesimaka Obreniokibo , Aluzaite Kristina , Braund Rhiannon , Schultz Michael
Published: January 2024

aims: Electronic health records (EHRs) are widely used in medication adherence (MA) assessment. Poor adherence in patients with inflammatory bowel diseases (IBD) can lead to worse disease outcomes and increased health costs. This study explores the suitability of southern New Zealand EHRs for estimating adherence, and the relationship between adherence and corticosteroid dispensings (indicating negative disease outcomes). methods: Medication dispensing EHR data of former Southern District Health Board IBD patients were analysed to estimate 3-year adherence, using daily polypharmacy possession ratio. The correlation with the number of corticosteroid dispensings was investigated. results: Of 248/1,290 (19%) consenting patients, only 108/248 (44%) had sufficient data available (46%/54% Crohn’s disease/ulcerative colitis; 57% female; 89.8%/0.9% NZ European/Māori; mean 5.1 corticosteroid dispensings). Mean adherence was 83.2% (95% confidence interval [CI] 80.0–86.4; standard deviation [SD]:16.7), with 69% of patients having MA ≥80% (good adherence). Median adherence was 13% higher for males versus females (96% vs 83%; p=0.0001). There was no correlation between adherence and the number of corticosteroid dispensings (Pearson’s r=0.11; p>0.05). These findings should be considered with caution as the data were not obtained from all pharmacies and the quantum/nature of missing data is unknown. conclusions: The patients’ adherence seems high, with no correlation with corticosteroid dispensings demonstrated. Useful EHR data are available but need optimisation for adherence assessments.
ANALISIS KEBUTUHAN PENANGANAN SIMPANG EMPAT JALAN KARANGAWEN KM-18 DI KABUPATEN DEMAK
Authors: Irvan Aditya Muhammad , Rizani Mohammad Debby , Ariawan Donny
Published: January 2024

The development of transportation in Demak Regency has an impact on increasing the movement of people, goods, and services. This is also very demanding for the improvement of transportation facilities and infrastructure in Demak Regency. This study aims to determine the performance of the uncited intersection of field conditions based on the 1997 MKJI guidelines, from the results of research in the field and the calculation of the Karangawen interchange interchange km 18 that the busiest traffic occurred on Sundays at 17.30-17.45 with a total traffic flow value of 1269 smp / hour, and obtained analytical data With an intersection capacity value of 1372.8 width of the interchange approach 2,821 fak tor road median adjustment with value 1, faktor city size adjustment with value 1, faktor road environment type adjustment by 0.85 faktor left turn adjustment by 1.170 faktor turn right adjustment by 0.233 Minor road ratio misrepresentation factor of 0.726 with a saturation degree of 0.924 interchange traffic delay of 56.54 seconds/smp,  main road traffic delay of 13.66 seconds/smp, minor road traffic delay of 61.67 seconds/smp, interchange geometry delay of 4, interchange delay of 60.54 Seconds/smp and queue opportunity for lower limit of 21.26 And queue opportunity for upper limit of 34.249.So the Karangawen km 18 intersection needs improvement at the intersection because it is seen from the value of the degree of saturation based on MKJI guidelines if the saturation value > 0.75 then there is a need for interchange improvement.
KAJIAN TINGKAT PENERAPAN GREEN CONSTRUCTION PADA PROYEK KONSTRUKSI GEDUNG FASILITAS PENDIDIKAN DI JAWA TIMUR
Authors: Laila Nurul Alfi Candra , Wiryasuta I Ketut Hendra , Hardiyanti Siska Aprilia
Published: January 2024

The construction of educational facilities in Indonesia, especially in East Java, are increase. However, this development has an environmental impact due to construction activities that use heavy equipment, produce material waste, and are less efficient in managing energy. To reduce this impact, it is important to implement green construction. The purpose of this research is to assess the level of green construction. The Model Assessment Green Construction (MAGC) method is used to assess the level of green construction implementation, focusing on environmentally friendly construction criteria and related indicators. The data from the questionnaire results, evaluating the weights of aspects and factors, were processed using the Analytical Hierarchy Process (AHP) method, resulting in aspect weight of 0.336 and factor weight of 0.821. These weight values become multiplier factors in the MAGC calculation. The results of the MAGC calculation obtain a percentage of 36% from 11 educational facility building construction projects in East Java that meet the NGCIdeal criteria within the baseline range of 15.47 to 21.92.
PERENCANAAN ULANG STRUKTUR GEDUNG LIMA LANTAI ASRAMA HAJI SEMARANG
Authors: Majid Ricky Abdul , Zhafira Talitha , Umar Wahyu Khoirul , Purwanto Purwanto
Published: January 2024

Due to the increasing number of Hajj pilgrims, the need for accommodating them has also risen. Therefore, a redesign is necessary to enhance the capacity of accommodating the pilgrims. The Analysis and Structural Planning of the Hajj Dormitory Semarang using ETABS software in compliance with the Indonesian National Standard (SNI). The redesign of the Hajj dormitory aims to augment the housing capacity for prospective Hajj pilgrims. The Revised Structural Planning for the Five-Story Hajj Dormitory Building Semarang aims to analyze and redesign the structure of the dormitory. This involves utilizing concrete quality of 24.9 MPa for the upper structure and 30 MPa for the lower structure, with main reinforcement using 420 MPa, while secondary reinforcement uses 280 MPa. The structural analysis approach involves inputting geometric data, loads, and material characteristics, including desired concrete and steel qualities, into the ETABS software. The analysis adheres to the SNI guidelines governing building loads, seismic resilience, and other structural safety factors. The analysis results provide insight into the structural response spectrum, with a mass participation of UX 99.98% and UY 99.19%. Control Base Shear Vdynamic > Vstatic, with Eq Dx > Eq Sx and Eq Dy > Eq Sy, is 8623.266 > 8563.3067 and 7928.0409 > 7722.4166. The maximum story displacement due to dynamic seismic motion in the X and Y directions is 14.33 mm and 15.95 mm. Meanwhile, the story drift with an Inelastic Drift value less than 61.5 mm for safety building permissible deviation. The largest permissible deviations obtained for the X and Y directions are 18.816 mm and 20.554 mm.
Pembersih Panel Surya 50W Menggunakan Wiper di Laboratorium Terpadu UNIPMA
Authors: Pratama Abdi , Yuniahastuti Irna Tri , Susilo Dody
Published: January 2024

Wilayah Indonesia terletak pada garis Katulistiwa. Kondisi geografis tersebut menyebabkan sinar matahari di Indonesia mencapai 4,8 kWh/m2/hari. Perkembangan teknologi, matahari dapat digunakan sebagai sumber listrik. Sumber listrik energi matahari menggunakan alat yaitu panel surya. Panel surya bisa menurun karena adanya kotoran, debu, dll. Hal tersebut menyebabkan penurunan daya listrik yang dihasilkan panel surya. Penelitian ini dilakukan di laboratorium terpadu Universitas PGRI Madiun. Tujuan penelitian, menghasilkan prototipe pembersih panel surya. Mengetahui efisiensi panel surya. Penelitian ini menggunakan metode eksperimental. Hasil penelitian ini pengujian dilakukan selama 14 hari dengan waktu 7 jam, yakni jam 09.00-15.00. Alat sebagai pembersih adalah wiper dengan penggerak servo, dikontrol oleh arduino. Daya rata-rata setiap jam sebelum dibersihkan 5,02 Watt efisiensinya 10,04%, setelah dibersihkan 6,65 Watt efisiensinya 13,3%. Sedangkan, daya rata-rata harian yang dihasilkan panel surya sebelum dibersihkan 5,01 Watt efisiensinya 10,02%, setelah dibersihkan 6,64 Watt efisiensinya 13,28%. Efisiensi dari spesifikasi panel surya 12,97%.
Jaringan Syaraf Tiruan untuk Memprediksi Pengambilan Keputusan untuk Memberikan Kredit kepada Calon Nasabah Baru
Authors: Nasir Januardi , Aranski Alvendo Wahyu , Setiawan Yasha Langitta
Published: January 2024

Kredit adalah proses meminjamkan uang kepada nasabah dengan ketentuan bahwa nasabah wajib mengembalikan uang yang dipinjamnya kembali kepada bank yang memberi pinjaman. Masalahnya adalah nasabah yang dibiayai atau yang diberi kredi ini memiliki karakter dan sifat yang bermacam-macam sehingga sulit untuk memastikan bahwa kredit tersebut akan dikembalikan seluruhnya. Bank menilai untuk memberikan kredit sering menggunakan prinsip 5 C (Character, Capital Capacity,Condition of Economy, dan Colateral).analisis yang paling rumit adalah analisis terhadap kondisi keuangan calon nasabah yaitu permodalan dan kemampuan calon nasabah dalam melakukan pengembalian kreditnya. Oleh karena itu perlu dikembangkan suatu alat analisis untuk menganalisis permodalan serta kemampuan calon nasabah dalam mengembalikan kreditnya. Untuk memudahkan analisis terhadap calon nasabah maka perlu dikembangkan suatu metode yang dapat meramalkan kualitas dari kredit yang akan diberikan kepada calon nasabah sehingga pihak bank memiliki analisis yang lebih tepat dalam pengambilan keputusan untuk memberikan kredit kepada calon nasabah baru, maka dikembangkanlah suatu metode jaringan syaraf tiruan yang menggunakan algoritma backpropagation sebagai alat bantu dalam menganalisis kualitas kredit yang akan diberikan tersebut. Hasil dari penelitian ini berupa sistem pengambilan keputusan yang memastikan pihak bank memberikan kredit berdasar prinsip 5 c tanpa harus takut dengan pemodalan nasabah baru.
Development of an Isoline Modeling Method for Extended Small Celestial Objects
Authors: Andreev A. O. , Nefedyev Yu. A. , Demina N. Yu.
Published: January 2024

This article presents a method for modeling extended small celestial (ESC) objects, which are mainly cometary systems. Special attention was given to the possibility of analyzing their structure and physical properties in line with the modern theories of the Solar System’s formation suggesting a rather complicated evolutionary dynamics. Modeling and investigating the structure of different extended celestial objects advance our understanding of the general evolutionary processes that have taken place in the Solar System because all its objects are evolutionarily related. The isoline modeling (IM) method was tested on the real comet data and proved effective in assessing the activity of the processes that occur as ESC objects move in space. The IM method is particularly useful for studying long-period comets that, in many cases, cross the perihelion only once within a foreseeable period of human existence.
Protein adsorpsiyon çalışmaları için metal şelat grupları içeren pHEMA-GMA kolon dolgu malzemelerinin hazırlanması
Authors: YILMAZ ALTINOK Bahar , KESKİNATEŞ Mukaddes , BAYRAKCI Mevlüt
Published: January 2024

Bu çalışmada, poly(HEMA-co-GMA) veya pHEMA-GMA olarak bilinen destek katı yapıları temin edildi. Hazırlanan pHEMA-GMA yapı malzemelerin yüzeyi IDA ve NTA gibi farklı fonksiyonel grupların bağlanması ile modifiye edildi. Modifiye edilen kriyojel yapılarından nikel (Ni II) metal iyonu geçirildi. Ni metali ile şelatlanan monolitik kriyojel yapısı SEM ve FT-IR ile karakterize edildi. Yapısı aydınlatılan bu farklı kriyojel yapıların GFP floresan protein bağlama çalışmaları UV-vis ve floresans spektrofotometresi ile yapıldı. UV-vis ve floresans spektrofotometresi ile ölçülen protein bağlama sonuçları SDS page yöntemi ile desteklenmiştir.
Coğrafi Bilgi Sistemi İle Hidroelektrik Enerji Üretimi Amaçlı Mini Hidroelektrik Santrali Yeri Seçimi: Sivas Kızılırmak Havzası Örneği
Authors: YILDIZ Sayiter , KARAKUŞ Can Bülent , BAYRAK Firdevs
Published: January 2024

Bu çalışmada, Coğrafi Bilgi Sistemi (CBS) tabanlı model yöntemi kullanılarak Kızılırmak Havzası'nda teorik olarak belirlenen mini hidroelektrik santrallerinin (MHES) lokasyonları tespit edilmiştir. Çalışma sonucunda, incelenen havzada kurulu güç potansiyeline göre 100-150 kWh arasında 151, 150-200 kWh arasında 19 ve 200-300 kWh arasında 13 yer tespit edildi. MHES potansiyelinin en yüksek olduğu noktaların Kızılırmak nehrinin ana kolu üzerinde yer aldığı tespit edilmiştir. Bu çalışma, bu havza içerisinde teorik olarak hesaplanabilecek hidroelektrik potansiyelini destekler nitelikte bir çalışmadır. Bu çalışma ile belirlenmiş enerji potansiyeli tahminleri, enerji kaynaklarının değerlendirilmesine yönelik daha fazla araştırma yapılmasını gerektirecek kadar önemlidir.
Intraoperative atrial rhythm changes during atrial fibrillation catheter ablation in patients with arterial hypertension and coronary artery disease
Authors: Gorev M. V. , Urazovskaya I. L. , Sayganov S. A.
Published: January 2024

Atrial fibrillation is a rhythm disorder with an extensive etiology and not fully understood pathogenesis. Catheter ablation is an effective way to control the rhythm of atrial fibrillation. The results of catheter ablation differ in patients with various comorbidities of the cardiovascular system. Intraoperative changes in the atrial rhythm can be a criterion for the long-term effectiveness of the operation or determine the need for additional effects.

Aim: To assess intraoperative changes in atrial rhythm during catheter ablation of atrial fibrillation in patients with concomitant pathology of the cardiovascular system.

Methodology and research methods. The results of catheter ablation of 451 patients with paroxysmal and persistent atrial fibrillation were analyzed retrospectively for the period from 2016 to 2017. After clinical and anamnestic data analysis, 151 patients with primary isolation of the pulmonary veins were selected. Depending on the concomitant pathology of the cardiovascular system, patients were divided into 3 groups: group 1 – with idiopathic atrial fibrillation, group 2 – atrial fibrillation in combination with isolated essential arterial hypertension and group 3 – atrial fibrillation in combination with ischemic heart disease.

Results. In patients with idiopathic atrial fibrillation, relief of atrial fibrillation with sinus rhythm preservation until the end of surgery was more often observed than in patients with ischemic heart disease (22% vs. 10,6%, р = 0,021). In patients with ischemic heart disease, typical atrial flutter was much more common and there was a need to perform radiofrequency ablation of the cavothricuspid isthmus in addition to isolation of the pulmonary veins (47,9% vs. 18,8% 1 Group 1, р = 0,005, and 24,7% in Group 2, р = 0,01).

Conclusions. The concomitant pathology of the cardiovascular system in patients affects the dynamics of the atrial rhythm during catheter treatment of atrial fibrillation and may take into account the definition of intraoperative tactics.
Clinical characteristics and assessment of structural and functional myocardium changes in patients with nonspecific connective tissue disorder
Authors: Loginova E. N. , Nechaeva G. I. , Dakuko A. N. , Bogatyrev I. V. , Potapov V. V. , Kirichenko N. A. , Sharoon I. V.
Published: January 2024

Early non-invasive diagnosis of structural changes in the heart plays an important role in optimizing approaches to preventing dangerous rhythm disorders at a young age.Aim: To study the phenotypic features of nonspecifi c connective tissue disorder (NCTD) in relation to the myocardial strain and the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with cardiac arrhythmias and NCTD.Results. There was an association between a local longitudinal left ventricular (LV) strain and pectus excavatum (r1 = 0.234, p = 0.008), joint hypermobility syndrome (r1 = 0.406, p = 0.026), spinal scoliosis (r1 = 0.266, p = 0.003), mitral valve prolapse (MVP) (r1 = 0.519, p = 0.003), diagnostic threshold of NCTD (r1 = 0.395, p = 0.031) in patients with arrhythmias and NCTD;there was an inverse weak to moderate association of body mass index (BMI) and myocardial strain in a number of LV segments. There was a signifi cant relationship between NT-proBNP and diagnostic threshold of NCTD (r1 = 0.496, p = 0.001), mitral valve prolapse (r1 = 0.469, p = 0.002).Conclusion. Chest deformity, spinal scoliosis, joint hypermobility, mitral valve prolapse and BMI decrease in patients with arrhythmic syndrome and NCTD are associated with the myocardial strain and NT-proBNP level that can be used for the early identifi cation of myocardial remodeling in this patient cohort.
Autologous inclusion technique versus Dacron inclusion technique in modified Ross surgery in adults: a retrospective single-center study
Authors: Chernov I. I. , Enginoev S. T. , Ziankov A. A. , Ekimov S. S. , Gamzaev A. B.
Published: January 2024

The Ross procedure has been shown to have excellent long-term outcomes. However, pulmonary autografts remain at risk of dilation in the long-term period. Therefore, the autologous inclusion technique (AIT) and the Dacron inclusion technique (DIT) have been developed. No direct comparison up to date has been reported of these two techniques.

Aim: To compare immediate and medium-term results performing various modified techniques of the Ross operation.

Material and Methods. The following retrospective study included 43 patients (AIT: 22; DIT: 21) aged 18 years and older with an aortic valve (AV) pathology who underwent modified Ross procedures (AIT and DIT) from January 2014 to December 2019, performed by a single surgeon. The main endpoints were: in-hospital mortality, postoperative AV pressure gradients, time of myocardial ischemia and cardiopulmonary bypass, postoperative complications (resternotomy due to bleeding, perioperative myocardial infarction, stroke, sternal infection, conduction disorder requiring implantation of a permanent pacemaker, acute renal failure requiring hemodialysis) and mid-term outcomes (freedom from reoperation, freedom from aortic dilatation ≥ 5 cm). The median follow-up period was 23 (12–68) months.

Results. The main indication for surgery was aortic regurgitation in 32 patients (74.4%). Bicuspid aortic valve was diagnosed in 29 (67.4%) patients. There were 33 (76.7%) males with an average age of 40 ± 11.7 years. There were no lethal outcomes in both groups. There was also no significant difference in postoperative complications. The peak and mean gradients on the AV were significantly lower in the AIT group than in the DIT group (6 and 4 mmHg vs 8 and 7 mmHg, p = 0.04). Five-year overall survival, freedom from reoperation on AV and PV, and freedom from dilatation of the ascending aorta ≥ 5 cm after modified Ross operation were 97.4%, 100%, and 100%, respectively. There was no statistically significant difference between groups in terms of overall survival (p = 0.66).

Conclusion. Both techniques, autologous inclusion and Dacron inclusion, provide excellent immediate and mid-term outcomes in terms of overall survival, freedom from reoperation and freedom from aortic dilation
Pathogenesis, predictors and prognostic scales for assessing the risk of reccurence of atrial fibrillation after catheter treatment: a literature review
Authors: Aripova N. R. , Abdullaeva A. A. , Zlobina P. D. , Kharlap M. S. , Davtyan K. V.
Published: January 2024

The review presents current data on atrial fibrillation (AF) recurrences after catheter-based interventional treatment. The most significant predictors described in various foreign and domestic sources are considered, and the most common in clinical practice scales for assessing the development of AF recurrences after intervention at the pulmonary vein orifices are presented. Unfortunately, currently there is no clear exhaustive validated scale to assess the occurrence of very late arrhythmia recurrence, but due to the high social and medical significance of this problem, the development of this scale represents an actual and demanded direction of modern arrhythmology. An analysis of clinical studies was carried out based on articles indexed in the Scopus, Higher Attestation Commission, Russian Science Citation Index, PubMed, and Web of Science databases.
Epigenetic factors of heart failure (review)
Authors: Kucher A. N. , Nazarenko M. S.
Published: January 2024

Heart failure (HF) is a widespread syndrome that leads to a significant decrease in the quality of life of patients. Epigenetics is one of the most promising areas of HF research, which allows us to consider the pathogenesis of this syndrome at a new molecular level. This review summarizes the studies of epigenetic processes (histone modification, DNA methylation, changes in the expression of regulatory non-coding RNAs) that accompany HF development. Epigenetic studies of HF not only confirmed the clinical and etiological heterogeneity of this syndrome, but also expanded the range of potential diagnostic markers and opened up new drug development strategies.
Optimal time of dual antiplatelet therapy in patients with coronary heart disease (literature review)
Authors: Gorgulko A. P. , Baranov A. A. , Khelimskii D. A. , Krestyaninov O. V. , Badoyan A. G.
Published: January 2024

However, the choice of optimal time of DAPT after PCI is still a difficult and urgent problem for the attending physician. An increase in DAPT duration after PCI correlates with a lower frequency of ischemic events. At the same time, with a longer DAPT regime, there is a more significant increase in the risks of postoperative bleeding. Hence, it is important to find a balance between the potential risks of bleeding and the expected benefits in reducing ischemic events, while taking into account the individual clinical characteristics of each patient. Intravascular imaging methods, such as intravascular coherence tomography, allow obtaining a highly informative lifetime morphological assessment of the coronary arteries, the formation of the neointima and the malposition of the implanted stent, which, in turn, can help in choosing the optimal timing of the DAPT and prevention of undesirable side events.