bluuebunny/crossref_metadata_2025 huggingface dataset:
Response to ‘“Legalists and Moralists” in the Historic Portrayal of the Constitution of the Church of England’
Authors: Milbank Alison
Published: September 2023

It is a great challenge to respond as a theologian to Professor Doe's magisterial survey in the article published in the previous pages of this Journal.I was asked to respond to the paper upon which that article is based from a theological perspective as part of the Ecclesiastical Law Society's 2022 day conference. Professor Doe demonstrates how, in the years between Hooker and the Church Assembly, ecclesiastical lawyers had recourse to both ethical, natural law arguments and those purely from legal or even positivistic ones. It is significant to see how frequently the Anglican theorist, Richard Hooker, is invoked throughout the article. He dates, of course, from the Reformation period when, as Harold Berman points out, a pre-Enlightenment jurisprudence still obtained which combined all three dimensions of law – the political, the moral, and the historical. In my view, what is important about Hooker is that he makes no separation between the legal and the ethical because law is divine in origin and even in God himself there is a law of his being: ‘the being of God is a kind of law to his working’ in giving his perfection to what he makes and ‘God is a law both to himself and to all other things beside’. Moreover, the ethical is only realised in what we decide to do and the laws we make. Law in Hooker is even Christological because, just as the Father begets the Logos (the Son), so the law proceeds as his continuing work in creation and history. To walk in God's ways and obey his laws is to be in union with Christ. Hooker was, of course, working out the meaning of the emerging Church of England in the Reformation Settlement, but even the pragmatic is itself participatory in the divine law and he appeals back to the natural law tradition for that reason.
Land Abundance, Openness, and Industrialization
Authors: Wood Adrian
Published: September 2023

With a modified formalization of Heckscher–Ohlin theory as the basis of a novel econometric specification, this paper uses worldwide data over three decades to estimate how the effects of greater openness on industrialization vary among countries with differing endowments of land relative to labour. The results confirm the theoretical prediction that greater openness reduces manufactured output shares in land-abundant countries, while increasing them in land-scarce countries. The implications of these results for trade and development policy are debatable.
Trade Preference Utilization Post-Brexit: The Role of Rules of Origin
Authors: Ayele Yohannes , Gasiorek Michael , Koecklin Manuel Tong
Published: September 2023

The degree to which firms make use of preferences in exporting to a partner country under a Free Trade Agreement will in good part depend on the restrictiveness of the underlying Rules of Origin (ROOs). Focusing on the post-Brexit Trade and Cooperation Agreement (TCA) signed by the United Kingdom and the European Union, we examine how access to zero preferential tariffs has been impacted by ROOs. We do so by constructing a ROO restrictiveness index which varies across products. We find that the TCA has an overall moderate degree of ROO restrictiveness. Using product-country level trade data, we find that preference utilization under the TCA has risen over time, and exhibits a positive correlation at the product level with the EU Common External Tariff. Regressions on the determinants of preference utilization indicate that more restrictive ROOs are associated with a lower degree of preference utilization by UK firms in the EU market and this effect is more evident for consumption goods. Preference utilization is also driven by the size of the preferential margin, the size of the trade flows, and the extent to which exports are undertaken by producers as opposed to distributors, as well as the degree of firms’ engagement in value chains.
An uncertainty-based risk management framework for climate change risk
Authors: Kiesel Rüdiger , Stahl Gerhard
Published: September 2023

Climate risks are systemic risks and may be clustered according to so-called volatilities, uncertainties, complexities, and ambiguities (VUCA) criteria. We analyze climate risk in the VUCA concept and provide a framework that allows to interpret systemic risks as model risk. As climate risks are characterized by deep uncertainties (unknown unknowns), we argue that precautionary and resilient principles should be applied instead of capital-based risk measures (reasonable for known unknows). A prominent example of the proposed principles is the precommitment approach (PCA). Within the PCA, subjective probabilities allow to discriminate between tolerable risks and acceptable ones. The amount of determined solvency capital for acceptable risks and estimations of model risk may be aggregated by means of a multiplier approach. This framework is in line with the three-pillar approach of Solvency II, especially with the recovery and resolution plan. Furthermore, it fits smoothly to a hybrid approach of micro- and macroprudential supervision.
CT-PTSD following a COVID-19 ICU admission in the context of unresolved grief, delirium and incurable cancer: a single case design with an older adult client
Authors: Peters Charlotte , Jenkins Kate , Paskell Rachel
Published: September 2023

This case study recounts an application of Ehlers and Clark’s (2000) cognitive model of post-traumatic stress disorder (PTSD) to post-intensive care unit (post-ICU) PTSD. An AB single case design was implemented. The referred patient, Rosalind (pseudonym), completed several psychometric measures prior to the commencement of therapy (establishing a baseline), as well as during and at the end of therapy. Idiosyncratic measures were also implemented to capture changes during specific phases of treatment. The importance of the therapeutic alliance, particularly in engendering a sense of safety, was highlighted. Findings support the use of cognitive therapy for PTSD (CT-PTSD) with an older adult, in the context of a coronavirus infectious disease (COVID-19)-related ICU admission. This case is also illustrative of the effectiveness of implementing CT-PTSD in the context of co–morbid difficulties and diagnoses of delirium, depression, and complicated grief.

Key learning aims

(1)

To recognise the therapeutic value of CT-PTSD in addressing PTSD following a COVID-19 admission, in the context of complicated grief and delirium.

(2)

To consider the importance of a strong therapeutic alliance when undertaking CT–PTSD.

(3)

To understand the intersection of complicated grief and delirium in the context of ICU trauma.

(4)

To consider the challenges in working with PTSD, whereby the target trauma (COVID–19 ICU admission) is linked with ongoing uncertainty and continuing indeterminate threat.
PM2.5 Exposure and Associated Premature Mortality to 2100 in China Under Climate and Socioeconomic Change Scenarios
Authors: Zou Bin , Xu Shan , Liu Ning , Li Shenxin , Liu Xiaoping , Guo Yuming , Zhan F. Benjamin
Published: September 2023

Reducing PM2.5‐related premature mortality is essential for health‐related sustainable development. China, one of the most populated and PM2.5 polluted developing countries in the world, is striving to be in the vanguard for meeting this target. However, the global chemical transport methods for future PM2.5 projections are difficult to use and computationally expensive and may import measurement uncertainty into regional exposure assessments, thus bringing challenges to policy making. Here, we proposed an integrated PM2.5 projection model framework based on regional land use, emission, climate and population simulations. The ambient PM2.5 exposure and associated premature mortality to 2100 in China at a scale of 10 × 10 km were projected and compared under different development pathways. Ambient PM2.5 exposure is expected to peak in recent decades (2030–2060) with mean values ranging from 32.72 to 35.11 μg/m3 for different pathways, while associated premature mortality are projected to decrease (2273.9–778.59) (in thousands) over time (2030–2100). The change in the emission scenario with significant CH4 and NMVOC increases could lead to the greatest increase in average PM2.5 exposure (4.03 μg/m3), while the decrease (−0.90 μg/m3) was linked to BC, SO2, CH4, and NMVOC decreases. Meanwhile, premature deaths decrease (15–226,424) for most projection periods when land use, emissions, and population data were separately replaced with RCP2.6‐SSP1 data. Land use impacts in socioeconomic change scenarios could be moderate in certain regions. Therefore, the sustainable development pathway of the RCP2.6‐SSP1 scenario should be prioritized in China for future development considering both environmental protection and health sustainability.
Fluid‐Mantle Interaction Along the Mariana Convergent Margin
Authors: Miladinova Irena , Kurz Walter , Hilmbauer‐Hofmarcher Thomas
Published: September 2023

Active serpentinite mud volcanoes in the forearc region of the Izu‐Bonin‐Mariana system represent an excellent natural laboratory for studying the geochemical processes along convergent plate margins and the associated forearc. During IODP Expedition 366, serpentinite mud with lithic clasts from the underlying forearc crust and mantle as well as from the subducting Pacific Plate was recovered. Ultramafic clasts from Fantangisña Seamount reveal very high degrees of serpentinization with mesh and bastite textures as well as development of late lizardite and chrysotile veins, which suggests serpentinization temperatures below 200°C. On the other hand, recovered harzburgites and, on occasion, dunites from Asùt Tesoru Seamount show a well‐preserved primary assemblage with low degrees of serpentinization and forearc peridotite characteristics. Fine‐grained antigorite associating with lizardite has been identified throughout the serpentine mud matrix, suggesting an alteration temperature of c. 340°C. Furthermore, alteration conditions during rodingitization point to temperatures of at least 228°C, estimated via chlorite geothermometry. Additionally, a rare ophicarbonate clast containing andraditic as well as Cr‐rich hydrogarnets from Asút Tesoru Seamount indicates crystallization temperatures of at least 230°C. Hence, a trend of lower temperature of serpentinization and higher degree of alteration closer to the trench. The detailed characterization of the fluid‐rock alteration conditions as well as fluids composition and transport permits a better constraining of the fluid–rock interactions and related mass transfers within subduction zones and during ascent of serpentinite fault gouge within mud volcano conduits and in mudflows after their emplacement on the flanks of the edifices.
Active Deformation Constraints on the Nubia‐Somalia Plate Boundary Through Heterogenous Lithosphere of the Turkana Depression
Authors: Musila M. , Ebinger C. J. , Bastow I. D. , Sullivan G. , Oliva S. J. , Knappe E. , Perry M. , Kounoudis R. , Ogden C. S. , Bendick R. , Mwangi S. , Mariita N. , Kianji G. , Kraus E. , Illsley‐Kemp F.
Published: September 2023

The role of lithospheric heterogeneities, presence or absence of melt, local and regional stresses, and gravitational potential energy in strain localization in continental rifts remains debated. We use new seismic and geodetic data to identify the location and orientation of the modern Nubia‐Somalia plate boundary in the 300‐km‐wide zone between the southern Main Ethiopian Rift (MER) and Eastern Rift (ER) across the Mesozoic Anza rift in the Turkana Depression. This region exhibits lithospheric heterogeneity, 45 Ma‐Recent magmatism, and more than 1,500 m of base‐level elevation change, enabling the assessment of strain localization mechanisms. We relocate 1716 earthquakes using a new 1‐D velocity model. Using a new local magnitude scaling with station corrections, we find 1 ≤ ML ≤ 4.5, and a b‐value of 1.22 ± 0.06. We present 59 first motion and 3 full moment tensor inversions, and invert for opening directions. We use complementary geodetic displacement vectors and strain rates to describe the geodetic strain field. Our seismic and geodetic strain zones demonstrate that only a small part of the 300 km‐wide region is currently active; low elevation and high‐elevation regions are active, as are areas with and without Holocene magmatism. Variations in the active plate boundary's location, orientation and strain rate appear to correspond to lithospheric heterogeneities. In the MER‐ER linkage zone, a belt of seismically fast mantle lithosphere generally lacking Recent magmatism is coincident with diffuse crustal deformation, whereas seismically slow mantle lithosphere and Recent magmatism are characterized by localized crustal strain; lithospheric heterogeneity drives strain localization.
Influence of Asian Topography on the Arctic Stratospheric Ozone
Authors: Wang Qilu , Duan Anmin , Pan Zhulei
Published: September 2023

Evaluating the impact of topography on stratospheric ozone is a crucial step toward achieving a deeper comprehension of the role of topography uplift in driving paleoclimatic evolution and stratospheric dynamics and chemistry. This paper quantitatively estimates the contribution of Asian topography to Arctic stratospheric ozone by topography experiments in the Whole Atmosphere Community Climate Model version 6. The results indicate that Asian topography exerts an especially robust influence on Arctic stratospheric ozone during winter. Compared to the flattened topography, Asian topography significantly increases the ozone by 15% in the lower Arctic stratosphere, accompanied by the highest accumulation of total ozone appearing in the polar region north to the North American continent. The intensified residual mean circulation transport is principally responsible for the increase in ozone, and Asian topography has a stronger impact on the vertical residual mean transport than on the meridional residual mean transport. Further examination demonstrates that the robust strengthening of planetary waves caused by Asian topography significantly contributes to the enhancement of the residual mean circulation. Specifically, the upper Arctic stratosphere experiences a 42.7% increase in the amplitude of planetary waves with wavenumber 1, which means the weakened polar vortex. The diagnosis of the mean Lorenz energy cycle further indicates that Asian topography decreases the zonal mean kinetic energy and increases the eddy kinetic energy in the stratosphere. Therefore, the enhancement of residual mean circulation transport and the weakening of the polar vortex both work together to promote the accumulation of Arctic ozone.
Subdaily Extreme Precipitation and Its Linkage to Global Warming Over the Tibetan Plateau
Authors: Ma Mengnan , Tang Jianping , Ou Tinghai , Chen Deliang
Published: September 2023

The spatiotemporal characteristics of subdaily extreme precipitation over the Tibetan Plateau (TP) have undergone significant changes due to global warming. In this study, we employed the high‐resolution Weather Research and Forecasting regional climate model to conduct a series of historical and projection simulations under representative concentration pathways (RCPs), especially RCP4.5 and RCP8.5. The aim was to investigate the past and future climatologies and spatiotemporal evolution of subdaily precipitation extremes using newly proposed subdaily extreme precipitation indices (EPIs). The results show that projected changes in precipitation amount, particularly during wet hours, exhibit spatial disparaties. Notably, there are significant decreases along the southern border of the TP and over the western TP, while obvious increases are observed over the inner TP. The southeastern TP, western TP, and southern border of the TP are expected to experience less frequent, shorter duration, and more intense precipitation on an hourly basis. The TP, as a whole, has demonstrated significantly increasing trends in moderate‐to‐heavy precipitation frequencies, along with consistent decreasing trends in precipitation events with short, medium, and long durations. Furthermore, it is predicted that the relationship between extreme precipitation and temperature will deviate from the Clausius‐Clapeyron (C‐C) relationship toward the double C‐C relationship in the far‐future under RCP8.5, particularly over the southeastern TP. Additionally, there are robust correlations between the intensity‐related EPIs and elevation. This indicates that, at the local scale, the complex topography of the region may play a crucial role in shaping the nonuniform distribution of precipitation extremes by modulating associated upward motion.
Investigating the Interhemispheric Asymmetry in Joule Heating During the 2013 St. Patrick's Day Geomagnetic Storm
Authors: Smith A. R. , Ozturk D. S. , Delamere P. , Lu G. , Kim H.
Published: September 2023

Sudden changes in energy input from the magnetosphere during geomagnetic storms could drive extreme variability in the ionosphere‐thermosphere system, which in turn affect satellite operations and other modern infrastructure. Joule heating is the main form of magnetospheric energy dissipation in the ionosphere‐thermosphere system, so it is important to know when and where Joule heating will occur. While Joule heating occurs all the time, it can increase rapidly during geomagnetic storms. We investigated the Joule heating profile of the 2013 St Patrick's day storm using the University of Michigan Global Ionosphere‐Thermosphere Model (GITM). Using empirical and data‐assimilated drivers we analyzed when and where intense Joule heating occurred. The timing, location, and sources of interhemispheric asymmetry during this geomagnetic storm are of key interest due to near equinox conditions. Hemispheric comparisons are made between parameters, including solar insolation, total electron content profiles, and Pedersen and Hall conductance profiles, obtained from GITM driven with empirical driven input, versus those driven with data‐assimilated patterns. Further comparisons are made during periods of peak hemispheric Joule heating asymmetry in an effort to investigate their potential sources. Additionally, we compare the consistency of the interhemispheric asymmetry between empirical‐ and data‐assimilated driven simulations to further analyze the role of data‐assimilated drivers on the IT system.
Interoceptive regulation of skeletal tissue homeostasis and repair
Authors: Xiao Yao , Han Changhao , Wang Yunhao , Zhang Xinshu , Bao Rong , Li Yuange , Chen Huajiang , Hu Bo , Liu Shen
Published: September 2023

Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process known as skeletal interoception, which is crucial for maintaining bone homeostasis. The hypothalamus, located in the central nervous system (CNS), plays a key role in processing interoceptive signals and regulating bone homeostasis through the autonomic nervous system, neuropeptide release, and neuroendocrine mechanisms. These mechanisms control the differentiation of mesenchymal stem cells into osteoblasts (OBs), the activation of osteoclasts (OCs), and the functional activities of bone cells. Sensory nerves extensively innervate skeletal tissues, facilitating the transmission of interoceptive signals to the CNS. This review provides a comprehensive overview of current research on the generation and coordination of skeletal interoceptive signals by the CNS to maintain bone homeostasis and their potential role in pathological conditions. The findings expand our understanding of intersystem communication in bone biology and may have implications for developing novel therapeutic strategies for bone diseases.
Osimertinib induces paraptosis and TRIP13 confers resistance in glioblastoma cells
Authors: Hu Lulu , Shi Ji , Shen Dachuan , Zhai Xingyue , Liang Dapeng , Wang Jing , Xie Chunrui , Xia Zhiyu , Cui Jing , Liu Feng , Du Sha , Meng Songshu , Piao Haozhe
Published: September 2023

The efficacy of osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, has been evaluated in glioblastoma (GBM) through preclinical and clinical trials. However, the underlying mechanism of osimertinib-induced GBM cell death and the underlying resistance mechanism to osimertinib remains unclear. Here, we demonstrate that Osimertinib induces paraptosis in GBM cells, as evidenced by the formation of cytoplasmic vacuoles, accumulation of ubiquitinated proteins, and upregulation of endoplasmic reticulum (ER) stress markers like CHOP. Additionally, neither apoptosis nor autophagy was involved in the osimertinib-induced cell death. RNAseq analysis revealed ER stress was the most significantly downregulated pathway upon exposure to osimertinib. Consistently, pharmacologically targeting the PERK-eIF2α axis impaired osimertinib-induced paraptosis. Notably, we show that the expression of thyroid receptor-interacting protein 13 (TRIP13), an AAA+ATPase, alleviated osimertinib-triggered paraptosis, thus conferring resistance. Intriguingly, MK-2206, an AKT inhibitor, downregulated TRIP13 levels and synergized with Osimertinib to suppress TRIP13-induced high GBM cell growth in vitro and in vivo. Together, our findings reveal a novel mechanism of action associated with the anti-GBM effects of osimertinib involving ER stress-regulated paraptosis. Furthermore, we identify a TRIP13-driven resistance mechanism against Osimertinib in GBM and offer a combination strategy using MK-2206 to overcome such resistance.
Identification of the bacteriophage nucleus protein interaction network
Authors: Enustun Eray , Deep Amar , Gu Yajie , Nguyen Katrina T. , Chaikeeratisak Vorrapon , Armbruster Emily , Ghassemian Majid , Villa Elizabeth , Pogliano Joe , Corbett Kevin D.
Published: September 2023

In the arms race between bacteria and bacteriophages (phages), some large-genome jumbo phages have evolved a protein shell that encloses their replicating genome to protect it against host immune factors. By segregating the genome from the host cytoplasm, however, the ‘phage nucleus’ introduces the need to specifically translocate messenger RNA and proteins through the nuclear shell and to dock capsids on the shell for genome packaging. Here, we use proximity labeling and localization mapping to systematically identify proteins associated with the major nuclear shell protein chimallin (ChmA) and other distinctive structures assembled by these phages. We identify six uncharacterized nuclear-shell-associated proteins, one of which directly interacts with self-assembled ChmA. The structure and protein–protein interaction network of this protein, which we term ChmB, suggest that it forms pores in the ChmA lattice that serve as docking sites for capsid genome packaging and may also participate in messenger RNA and/or protein translocation.
Creativity and productivity during the COVID-19 pandemic
Authors: Görlich Yvonne
Published: September 2023

This study explored impacts of the COVID-19 pandemic on creativity and productivity and how personality variables moderated these impacts. Two online self-report surveys were conducted. 863 (spring 2020) and 421 (spring 2021) participants were asked how the corona crisis affected their creativity and productivity. In addition, personality variables, namely the Big Five (openness, conscientiousness, extraversion, agreeableness, neuroticism), as well as interpersonal trust, need for cognition, risk-taking, and life satisfaction, were assessed. As a result of the crisis, the group of participants appeared more creative in 2020, while no significant group effect of the pandemic was found for productivity. In 2021, however, the crisis had a negative impact on creativity and productivity. In 2020, predictors for an improved creativity were openness, conscientiousness, neuroticism, and life satisfaction; predictors for improved productivity were conscientiousness, negative interpersonal trust, and life satisfaction. In 2021, only life satisfaction predicted improved creativity, while improved productivity was predicted by conscientiousness, negative neuroticism, and life satisfaction. At its beginning, the COVID-19 pandemic had, on average, a positive effect on creativity and a neutral one on productivity. Later, the impact turned negative on both creativity and productivity. Here, lower life satisfaction was particularly relevant.
Power system low delay resource scheduling model based on edge computing node
Authors: Zhao Ying , Ye Hua
Published: September 2023

As more and more intelligent devices are put into the field of power system, the number of connected nodes in the power network is increasing exponentially. Under the background of smart grid cooperation across power areas and voltage levels, how to effectively process the massive data generated by smart grid has become a difficult problem to ensure the stable operation of power system. In the complex calculation process of power system, the operation time of complex calculation can not be shortened to the greatest extent, and the execution efficiency can not be improved. Therefore, this paper proposes a two-phase heuristic algorithm based on edge computing. In solving the virtual machine sequence problem, for the main partition and the coordination partition, the critical path algorithm is used to sort the virtual machines to minimize the computing time. For other sub-partitions, the minimum cut algorithm is used to reduce the traffic interaction of each sub-partition. In the second stage of the virtual machine placement process, an improved best fit algorithm is used to avoid poor placement of virtual machines across physical machine configurations, resulting in increased computing time. Through the experiment on the test system, it is proved that the calculation efficiency is improved when the coordinated partition calculation belongs to the target partition. Because the edge computing is closer to the data source, it can save more data transmission time than cloud computing. This paper provides an effective algorithm for power system distributed computing in virtual machine configuration in edge computing, which can effectively reduce the computing time of power system and improve the efficiency of system resource utilization.
Inferring linear-B cell epitopes using 2-step metaheuristic variant-feature selection using genetic algorithm
Authors: Angaitkar Pratik , Aljrees Turki , Kumar Pandey Saroj , Kumar Ankit , Janghel Rekh Ram , Sahu Tirath Prasad , Singh Kamred Udham , Singh Teekam
Published: September 2023

Linear-B cell epitopes (LBCE) play a vital role in vaccine design; thus, efficiently detecting them from protein sequences is of primary importance. These epitopes consist of amino acids arranged in continuous or discontinuous patterns. Vaccines employ attenuated viruses and purified antigens. LBCE stimulate humoral immunity in the body, where B and T cells target circulating infections. To predict LBCE, the underlying protein sequences undergo a process of feature extraction, feature selection, and classification. Various system models have been proposed for this purpose, but their classification accuracy is only moderate. In order to enhance the accuracy of LBCE classification, this paper presents a novel 2-step metaheuristic variant-feature selection method that combines a linear support vector classifier (LSVC) with a Modified Genetic Algorithm (MGA). The feature selection model employs mono-peptide, dipeptide, and tripeptide features, focusing on the most diverse ones. These selected features are fed into a machine learning (ML)-based parallel ensemble classifier. The ensemble classifier combines correctly classified instances from various classifiers, including k-Nearest Neighbor (kNN), random forest (RF), logistic regression (LR), and support vector machine (SVM). The ensemble classifier came up with an impressively high accuracy of 99.3% as a result of its work. This accuracy is superior to the most recent models that are considered to be state-of-the-art for linear B-cell classification. As a direct consequence of this, the entire system model can now be utilised effectively in real-time clinical settings.
RETRACTED ARTICLE: Hybrid CNN-LSTM model with efficient hyperparameter tuning for prediction of Parkinson’s disease
Authors: Lilhore Umesh Kumar , Dalal Surjeet , Faujdar Neetu , Margala Martin , Chakrabarti Prasun , Chakrabarti Tulika , Simaiya Sarita , Kumar Pawan , Thangaraju Pugazhenthan , Velmurugan Hemasri
Published: September 2023

The patients’ vocal Parkinson’s disease (PD) changes could be identified early on, allowing for management before physically incapacitating symptoms appear. In this work, static as well as dynamic speech characteristics that are relevant to PD identification are examined. Speech changes or communication issues are among the challenges that Parkinson’s individuals may encounter. As a result, avoiding the potential consequences of speech difficulties brought on by the condition depends on getting the appropriate diagnosis early. PD patients’ speech signals change significantly from those of healthy individuals. This research presents a hybrid model utilizing improved speech signals with dynamic feature breakdown using CNN and LSTM. The proposed hybrid model employs a new, pre-trained CNN with LSTM to recognize PD in linguistic features utilizing Mel-spectrograms derived from normalized voice signal and dynamic mode decomposition. The proposed Hybrid model works in various phases, which include Noise removal, extraction of Mel-spectrograms, feature extraction using pre-trained CNN model ResNet-50, and the final stage is applied for classification. An experimental analysis was performed using the PC-GITA disease dataset. The proposed hybrid model is compared with traditional NN and well-known machine learning-based CART and SVM & XGBoost models. The accuracy level achieved in Neural Network, CART, SVM, and XGBoost models is 72.69%, 84.21%, 73.51%, and 90.81%. The results show that under these four machine approaches of tenfold cross-validation and dataset splitting without samples overlapping one individual, the proposed hybrid model achieves an accuracy of 93.51%, significantly outperforming traditional ML models utilizing static features in detecting Parkinson’s disease.
Immuno-physiological effects of dietary reishi mushroom powder as a source of beta-glucan on Rohu, Labeo rohita challenged with Aeromonas veronii
Authors: Saha Tutul Kumar , Mariom  , Rahman Tanvir , Moniruzzaman Mohammad , Min Taesun , Hossain Zakir
Published: September 2023

Beta-glucans have immense potential to stimulate immune modulation in fish by being injected intramuscularly, supplemented with feed or immersion routes of administration. We studied how supplementing Labeo rohita’s diet with reishi mushroom powder containing beta-glucan influenced immunological function. A supplemented diet containing 10% reishi mushroom powder was administered for 120 days. Afterwards, analyses were conducted on different immunological parameters such as antioxidants, respiratory burst, reactive oxygen species (ROS), alternative complement activity, and serum immunoglobulin, which resulted significant increases (p < 0.05; p < 0.01) for the reishi mushroom-fed immune primed L. rohita. Additionally, analyzing various hematological parameters such as erythrocytes and leukocytes count were assessed to elucidate the immunomodulatory effects, indicating positive effects of dietary reishi mushroom powder on overall fish health. Furthermore, the bacterial challenge-test with 1.92 × 104 CFU/ml intramuscular dose of Aeromonas veronii showed enhanced disease-defending system as total serum protein and lysozyme activity levels accelerated significantly (p < 0.01). Nevertheless, reishi mushroom powder contained with beta-glucan ameliorated the stress indicating parameters like acetylcholinesterase (AChE), serum-glutamic pyruvic transaminase (SGPT) and serum-glutamic oxaloacetic transaminase (SGOT) enzyme activities results suggested the fish’s physiology was unaffected. Therefore, the results indicated that adding dietary reishi mushroom as a source of beta-glucan could significantly boost the immune responses in Rohu.
Intestinal health of broilers challenged with Eimeria spp. using functional oil blends in two physical forms with or without anticoccidials
Authors: de Oliveira Moraes Priscila , da Silva Pires Paula Gabriela , Benetti Filho Vilmar , Lima André Luís Ferreira , Kindlein Liris , Taschetto Diogo , Favero André , Wagner Glauber
Published: September 2023

This study aimed to assess the impact of a commercial blend of functional oils, specifically cashew nutshell liquid and castor oil (FO), in two physical forms (solid: P; liquid: S), in comparison to a combination of virginiamycin and anticoccidials on the gut health of broilers challenged with coccidiosis. A total of 1760 1-day-old male chicks were randomly distributed in a study design with eight treatments. The treatments included: a control group (without additive), OFS_0.75_kg/t (FO spray), OFP_1.0_kg/t (FO powder), OFP_1.5_kg/t (FO liquid spray), Sal (anticoccidials), Sal_Vir (virginiamycin and anticoccidials), Sal_OFS_0.5_ kg/t (anticoccidials plus FO spray), and Sal_OFP_1.0_kg/t (anticoccidials plus FO powder). All birds were challenged with Eimeria spp. at 14 days. The physical form of FO did not affect performance and intestinal health parameters. At 42 days, broilers from the control and OFS_0.75 treatments were the lightest, while those from the Sal_Vir and Sal_OFP_1.0 treatments were the heaviest (P < 0.05). FO reduced the presence of Clostridium perfringens. The individual phytogenic additives did not prevent weight loss in birds challenged with Eimeria, but they mitigated the effects of the infection by modulating the intestinal microbiota. A synergistic effect was observed between the FO and anticoccidials, yielding satisfactory results in substituting virginiamycin.
An enhanced turbulent flow of water-based optimization for optimal power flow of power system integrated wind turbine and solar photovoltaic generators
Authors: Zahedibialvaei Amir , Trojovský Pavel , Hesari-Shermeh Maryam , Matoušová Ivana , Trojovská Eva , Hubálovský Štěpán
Published: September 2023

This paper uses enhanced turbulent flow in water-based optimization (TFWO), specifically ETFWO, to achieve optimal power flow (OPF) in electrical networks that use both solar photovoltaic (PV) units and wind turbines (WTs). ETFWO is an enhanced TFWO that alters the TFWO structure through the promotion of communication and collaboration. Individuals in the population now interact with each other more often, which makes it possible to search more accurately in the search area while ignoring local optimal solutions. Probabilistic models and real-time data on wind speed and solar irradiance are used to predict the power output of WT and PV producers. The OPF and solution methods are evaluated using the IEEE 30-bus network. By comparing ETFWO to analogical other optimization techniques applied to the same groups of constraints, control variables, and system data, we can gauge the algorithm’s robustness and efficiency in solving OPF. It is shown in this paper that the proposed ETFWO algorithm can provide suitable solutions to OPF problems in electrical networks with integrated PV units and WTs in terms of energy generation costs, improved voltage profiles, emissions, and losses, compared to the traditional TFWO and other proposed algorithms in recent studies.
Associations of physical activity types and intensity with cardiovascular diseases by age and gender among 18,730 Chinese adults
Authors: Lin Beilei , Zhang Zhenxiang , Zhang Weihong , Zhang Chunhui , Xue Lihong , An Baoxia , Wang Kaijuan
Published: September 2023

The associations of physical activity (PA) intensity and types with CVD (cardiovascular diseases) in different population are inconsistent and remains not very clear. A total of 7854 males and 10,876 females over 15 years were selected by multistage random sampling methods. In males, moderate-intensity physical activity (MPA) had no effect, while vigorous-intensity physical activity (VPA) played a significant protective role (OR = 1.319 and 0.615). However, in females, both MPA and VPA had significant protective effects (OR = 0.593 and 0.537). VPA presented as a significant protective factor in stroke patients and combined CVDs for males in all age groups; however, in females, the results suggested that, for those aged over 60–74 years, MPA was a protective factor. Furthermore, for the middle-aged or younger participants, the area under the curves (AUCs) of work, housework, and leisure activity were generally higher than that of other types, while for patients aged over 60 years, the AUCs of sedentary time and sleep activity seemed much higher. VPA had a better protective effect for preventing cardiovascular events, while the young and female population could benefit from MPA as well. Regardless of the types of PA, leisure activities were strongly recommended, and young people were much more likely to benefit from exercise than older people.
Function of a mutant ryanodine receptor (T4709M) linked to congenital myopathy
Authors: Magyar Zsuzsanna É. , Hevesi Judit , Groom Linda , Dirksen Robert T. , Almássy János
Published: September 2023

Physiological muscle contraction requires an intact ligand gating mechanism of the ryanodine receptor 1 (RyR1), the Ca2+-release channel of the sarcoplasmic reticulum. Some mutations impair the gating and thus cause muscle disease. The RyR1 mutation T4706M is linked to a myopathy characterized by muscle weakness. Although, low expression of the T4706M RyR1 protein can explain in part the symptoms, little is known about the function RyR1 channels with this mutation. In order to learn whether this mutation alters channel function in a manner that can account for the observed symptoms, we examined RyR1 channels isolated from mice homozygous for the T4709M (TM) mutation at the single channel level. Ligands, including Ca2+, ATP, Mg2+ and the RyR inhibitor dantrolene were tested. The full conductance of the TM channel was the same as that of wild type (wt) channels and a population of partial open (subconductive) states were not observed. However, two unique sub-populations of TM RyRs were identified. One half of the TM channels exhibited high open probability at low (100 nM) and high (50 μM) cytoplasmic [Ca2+], resulting in Ca2+-insensitive, constitutively high Po channels. The rest of the TM channels exhibited significantly lower activity within the physiologically relevant range of cytoplasmic [Ca2+], compared to wt. TM channels retained normal Mg2+ block, modulation by ATP, and inhibition by dantrolene. Together, these results suggest that the TM mutation results in a combination of primary and secondary RyR1 dysfunctions that contribute to disease pathogenesis.
Photothermal effects of terahertz-band and optical electromagnetic radiation on human tissues
Authors: Reddy Innem V. A. K , Elmaadawy Samar , Furlani Edward P. , Jornet Josep M.
Published: September 2023

The field of wireless communication has witnessed tremendous advancements in the past few decades, leading to more pervasive and ubiquitous networks. Human bodies are continually exposed to electromagnetic radiation, but typically this does not impact the body as the radiation is non-ionizing and the waves carry low power. However, with progress in the sixth generation (6G) of wireless networks and the adoption of the spectrum above 100 GHz in the next few years, higher power radiation is needed to cover larger areas, exposing humans to stronger and more prolonged radiation. Also, water has a high absorption coefficient at these frequencies and could lead to thermal effects on the skin. Hence, there is a need to study the radiation effects on human tissues, specifically the photothermal effects. In this paper, we present a custom-built, multi-physics model to investigate electromagnetic wave propagation in human tissue and study its subsequent photothermal effects. The proposed finite-element model consists of two segments—the first one estimates the intensity distribution along the beam path, while the second calculates the increase in temperature due to the wave distribution inside the tissue. We determine the intensity variation in the tissue using the radiative transfer equation and compare the results with Monte Carlo analysis and existing analytical models. The intensity information is then utilized to predict the rise in temperature with a bio-heat transfer module, powered by Pennes’ bioheat equation. The model is parametric, and we perform a systematic photothermal analysis to recognize the crucial variables responsible for the temperature growth inside the tissue, particularly for terahertz and near-infrared optical frequencies. Our numerical model can serve as a benchmark for studying the high-frequency radiation effects on complex heterogeneous media such as human tissue.
Subsets of preoperative sex hormones in testicular germ cell cancer: a retrospective multicenter study
Authors: Törzsök Péter , Oswald David , Dieckmann Klaus-Peter , Angerer Markus , Scherer Lukas Christian , Tymoszuk Piotr , Kunz Yannic , Pinggera Germar-Michael , Lusuardi Lukas , Horninger Wolfgang , Pichler Renate
Published: September 2023

Preoperative homeostasis of sex hormones in testicular germ cell tumor (TGCT) patients is scarcely characterized. We aimed to explore regulation of sex hormones and their implications for histopathological parameters and prognosis in TGCT using a data-driven explorative approach. Pre-surgery serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), estradiol (E2) and prolactin were measured in a retrospective multicenter TGCT cohort (n = 518). Clusters of patients were defined by latent class analysis. Clinical, pathologic and survival parameters were compared between the clusters by statistical hypothesis testing, Random Forest modeling and Peto-Peto test. Cancer tissue expression of sex hormone-related genes was explored in the publicly available TCGA cohort (n = 149). We included 354 patients with pure seminoma and 164 patients with non-seminomatous germ cell tumors (NSGCT), with a median age of 36 years. Three hormonal clusters were defined: ‘neutral’ (n = 228) with normal sex hormone homeostasis, ‘testicle’ (n = 91) with elevated T and E2, low pituitary hormones, and finally ‘pituitary’ subset (n = 103) with increased FSH and LH paralleled by low-to-normal levels of the gonadal hormones. Relapse-free survival in the hormonal subsets was comparable (p = 0.64). Cancer tissue expression of luteinizing hormone- and follicle-stimulating hormone-coding genes was significantly higher in seminomas, while genes of T and E2 biosynthesis enzymes were strongly upregulated in NSGCT. Substantial percentages of TGCT patients are at increased risk of sex hormone dysfunction at primary diagnosis before orchiectomy. TGCT may directly influence systemic hormonal homeostasis by in-situ synthesis of sex hormones.
Relevance of circulating Semaphorin 4A for rheumatoid arthritis response to treatment
Authors: Avouac Jérôme , Vandebeuque Eloïse , Combier Alice , Poiroux Lucile , Steelandt Alexia , Boisson Margaux , Gonzalez Virginie , Cauvet Anne , Barnetche Thomas , Truchetet Marie-Elise , Richez Christophe , Allanore Yannick
Published: September 2023

The lack of validated tools to predict rheumatoid arthritis (RA) disease course warrants the development of new reliable biomarkers. Our aim was to evaluate the merit of circulating SEMA4A for the prediction of outcomes in patients with RA. In a first cohort of 101 consecutive RA patients followed up for 41 ± 15 months, increased baseline SEMA4A levels were identified as an independent predictor of treatment failure (hazard ratio, HR 2.71, 95% CI 1.14–6.43), defined by the occurrence of patient-reported flares and initiation or change of targeted therapy. The highest predictive value of treatment failure was obtained with the combination of increased circulating SEMA4A and/or Disease Activity Score (DAS) 28-CRP > 3.2 and/or active synovitis on doppler ultrasound (HR 10.42, 95% CI 1.41–76.94). In a second independent cohort of 40 consecutive RA patients who initiated new therapy because of insufficient disease control, baseline SEMA4A levels were significantly higher in patients who further experienced none or moderate response, and SEMA4A concentrations were markedly decreased in the group of patients with good clinical response as compared to non-responders. Circulating SEMA4A appears as an appealing biomarker in RA with ability to predict treatment failure, and with association with response to therapy.
Inclusive fitness forces of selection in an age-structured population
Authors: Roper Mark , Green Jonathan P. , Salguero-Gómez Roberto , Bonsall Michael B.
Published: September 2023

Hamilton’s force of selection acting against age-specific mortality is constant and maximal prior to the age of first reproduction, before declining to zero at the age of last reproduction. The force of selection acting on age-specific reproduction declines monotonically from birth in a growing or stationary population. Central to these results is the assumption that individuals do not interact with one another. This assumption is violated in social organisms, where an individual’s survival and/or reproduction may shape the inclusive fitness of other group members. Yet, it remains unclear how the forces of selection might be modified when inclusive fitness, rather than population growth rate, is considered the appropriate metric for fitness. Here, we derive such inclusive fitness forces of selection, and show that selection on age-specific survival is not always constant before maturity, and can remain above zero in post-reproductive age classes. We also show how the force of selection on age-specific reproduction does not always decline monotonically from birth, but instead depends on the balance of costs and benefits of increasing reproduction to both direct and indirect fitness. Our theoretical framework provides an opportunity to expand our understanding of senescence across social species.
Investigating the mechanical stability of flexible metal–organic frameworks
Authors: Son Florencia A. , Fahy Kira M. , Gaidimas Madeleine A. , Smoljan Courtney S. , Wasson Megan C. , Farha Omar K.
Published: September 2023

As we continue to develop metal–organic frameworks (MOFs) for potential industrial applications, it becomes increasingly imperative to understand their mechanical stability. Notably, amongst flexible MOFs, structure-property relationships regarding their compressibility under pressure remain unclear. In this work, we conducted in situ variable pressure powder X-ray diffraction (PXRD) measurements up to moderate pressures (<1 GPa) using a synchrotron source on two families of flexible MOFs: (i) NU-1400 and NU-1401, and (ii) MIL-88B, MIL-88B-(CH3)2, and MIL-88B-(CH3)4. In this project scope, we found a positive correlation between bulk moduli and degree of flexibility, where increased rigidity (e.g., smaller swelling or breathing amplitude) arising from steric hindrance was deleterious, and observed reversibility in the unit cell compression of these MOFs. This study serves as a primer for the community to begin to untangle the factors that engender flexible frameworks with mechanical resilience.