bluuebunny/crossref_metadata_2025 huggingface dataset:
Usability and Effectiveness of Interactive Online International Exchange Program for Occupational Therapy Students
Authors: Suyama Natsuka , Inoue Kaoru , Sorasak Supatida , Thawisuk Chirathip , Watanabe Masaru
Published: December 2022

The COVID-19 pandemic affected international exchange programs due to travel restrictions. There are few reports of online international exchange programs in medical area and no report of interactive activities among students together for several months. To the best of our knowledge, we needed to seek the effective approach to conduct online exchange program. We experienced online collaboration works to promote internationalization in occupational therapy (OT) undergraduate education. The aim of this study is to examine the usability and effectiveness of an interactive online international exchange program, and discuss its usefulness and challenges. The three-month program was newly developed, and aimed at cultivating an international perspective, understanding OT, and learning basic research skills. Students’ interests and the development of their motivation were considered in the program consisting of synchronous and asynchronous lectures, a collaboration research project, group work, and report assignments. Through the program, students were satisfied with the program contents and had the precious experience to develop international relationships. The online exchange program provided students with the opportunity to experience and learn OT education internationally at an economical cost, and to achieve program goal during the regular semester. In this program, students not only acquired knowledge in their professional field, but also cultivated their international communication skills in English from small group activities and social activities. Considering various communication methods was an important aspect in the virtual environment leading to a successful program. In medical education, an online program can be an effective and practical measure for international exchange.
Comparison of efficacy and safety of carboplatin combined with nab-paclitaxel or paclitaxel as first-line therapy for advanced thymic epithelial tumors
Authors: Hao Yue , Si Jinfei , Wei Jingwen , Gu Xiaodong , Wang Wenxian , Zhang Yuxin , Guan Yelan , Huang Hao , Xu Chunwei , Song Zhengbo
Published: December 2022

Background: Paclitaxel/carboplatin (PC) is the standard first-line chemotherapy for advanced thymoma and thymic carcinoma. However, although nanoparticle albumin-bound (nab)-PC and PC have exhibited efficacy in various solid tumors, data for thymic epithelial tumors are lacking, including a comparison of the efficacies of nab-PC and PC.
Methods: We conducted a retrospective study to compare the efficacy and safety of nab-PC with PC in previously untreated patients with advanced thymoma and thymic carcinoma. We analyzed the objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and treatment-related adverse events (AEs). Cox proportional hazards regression analyses were carried out to determine the factors independently associated with survival.
Results: Ninety-one patients were enrolled from October 2006 to September 2021. The ORRs in patients treated with nab-PC and PC were 48.8% vs 36%, respectively (P=0.219). Among patients with thymic carcinoma, PFS differed between the nab-PC and PC groups (10.5 vs 6.3 months, P=0.0049); however, no such difference occurred in the thymoma group (13.8 vs 12.3 months, P=0.6948). The median OS was 27.4 months in 54 patients in thymic carcinoma, but was not reached for thymoma patients (P=0.0024).
Conclusions: Nab-PC may be more effective than PC as first-line therapy in patients with advanced thymic epithelial tumors. Nab-PC could thus become an alternative regimen in patients with thymic epithelial tumors, especially thymic carcinoma.
SlowTrack: Detecting Slow Rate Denial of Service Attacks againstHTTP with Behavioral Parameters
Authors: Sood Shaurya , Hubballi Neminath
Published: December 2022

Denial of Service (DoS) attacks have evolved from volumetric attacks to target specific applications and can cripple different services with very limited effort. Hypertext Transfer Protocol (HTTP) is vulnerable to a slow rate DoS attack generated through prolonged connections which deliberately send incomplete requests to server. Simple detection methods which use $x$ number of such connections in $y$ time can be easily evaded. In this paper, we present SlowTrack which can detect slow rate DoS attacks against HTTP using a set of behavioral parameters. SlowTrack uses eight behavioral parameters which are validated to be useful in identifying the attack. We correlate these parameters to understand how their values change when attack is launched and subsequently use these observations to propose detection methods. \texttt{SlowTrack} is composed of three detection algorithms which make use of these observations for detecting attacks. We evaluate the detection performance of \texttt{SlowTarck} using experiments done in a testbed and also in a live network to show that these algorithms can detect the slow rate attacks effectively.
The war year 2022 is a year of trials for the journal and the publishing house
Authors: Kozmenko Serhiy , Ostapenko Liudmyla
Published: December 2022

There were many trials and obstacles on the way of the journal and publishing house. However, these were problems with growth, but on the morning of February 24, 2022, a terrible thing began. We woke up to cannon shots (in a European country in the 21st century!!!), and by evening the Russian monster was squeezing the streets of our cities with its tentacles from hundreds of pieces of equipment and thousands of soldiers. War! How events developed further is another story. Or rather, tens of millions of stories of people who have suffered and are suffering from this absolutely illogical, surreal, and barbaric war. Here we will briefly recall the past year, as the twentieth year since the birth of the Publishing Company “Business Perspectives” and its first journal “Problems and Perspectives in Management.” About a year of work in a real and terrible war.
Educación e Inteligencia Artificial: Nodos temáticos de inmersión
Authors: González González Rafael Alberto , Silveira Bonilla Maria Helena
Published: December 2022

El corriente artículo examina, desde el punto de vista del discurso científico, algunos de los nodos temáticos más importantes que se vienen produciendo en lo que compete a la relación educación-Inteligencia Artificial. A tales efectos, una revisión de 72 artículos académicos seleccionados de la base de datos ERIC (Education Resources Information Center), permitió no solo trazar la red tópica a partir de la cual se vienen constituyendo los principales Fenómenos Transversales, el Dispositivo Tecnológico y la Matriz Educativa, que ocupa la atención científico-académica en lo que compete al campo de saber en consideración, sino que a su vez posibilitó apreciar la smartificación de la educación como uno de los fenómenos más dinámicos que emergen en el nodo definido por términos educación-IA.
Análisis comparativo de las redes sociales de centros públicos y privados/concertados de Secundaria en Cantabria
Authors: Álvarez-Álvarez Carmen , Del Puerto Carrizosa María José
Published: December 2022

Las redes sociales, el aumento en el uso de las nuevas tecnologías, las mejoras de Internet, y la evolución de los dispositivos móviles han generado una revolución en el marco del sistema educativo, lo que ha supuesto que los centros escolares hayan tenido que reformular sus estrategias de comunicación social. El objetivo de esta investigación es comparar los usos que hacen los centros públicos y privados/concertados de sus webs y redes sociales (centrándonos con especial interés en Instagram) para determinar cómo se están adaptando en este nuevo contexto digital. Para ello, se ha diseñado un estudio observacional analizando el contenido publicado en las distintas webs y redes sociales de todos los centros de Educación Secundaria de Cantabria (92 centros). Se ha analizado la frecuencia de publicación, la interacción, el compromiso y el tipo de publicación. Los resultados muestran que los centros privados/concertados tienen una mayor implicación en la creación y publicación de contenido de valor en webs y redes sociales, para conectar con la comunidad escolar, que los centros públicos. No obstante, es posible concluir que la mayor parte de los centros educativos no tienen pautas de comunicación establecidas para las plataformas sociales.
INDÚSTRIA DE TRANSFORMAÇÃO BRASILEIRA: UMA ANÁLISE DAS EXPECTATIVAS DOS EMPRESÁRIOS E DO EMPREGO (2003-2017)
Authors: Alves Ribeiro Laudelina , Stamm Cristiano
Published: December 2022

O presente estudo tem a finalidade de analisar a influência da expectativa dos empresários da indústria de transformação brasileira sobre o emprego da mesma. O período compreendido no estudo é de 2003 a 2017, com a base de dados mensal. Para avaliar os resultados, o método econométrico utilizado foi estimado pelo Modelo Vetor de Correção de Erros (VECM). Os resultados apontam que, no período estudado, a expectativa dos empresários da indústria de transformação influenciou as decisões relacionadas com o emprego desse setor. Sendo assim, um cenário econômico estável proporciona um aumento da confiança dos empresários industriais, fazendo crescer sua expectativa em relação a seus negócios futuros e à economia do país e proporcionando um aumento dos empregos industriais, que podem impulsionar o crescimento da atividade do setor industrial e das demais atividades econômicas do país.
NOTAS SOBRE A FUNÇÃO CONTRADITÓRIA DO GASTO SOCIAL
Authors: Gonçalves Wagna Maquis Cardoso de Melo
Published: December 2022

Analisa-se o montante, o destino e a relevância do gasto social nos estados do Rio Grande do Norte, Paraíba e Maranhão (2015 a 2018). Utilizou-se suas respectivas despesas orçamentárias empenhadas com os gastos de ordem social. Agrupou-se as despesas em políticas de Proteção Social e de Promoção Social. Identificou-se que a) o gasto com proteção social é mais representativo e com proporções distintas por área; b) a relação gasto social/gasto total cresceu, exceto no estado do Maranhão; e c) a relevância do gasto social demonstra-se forte, positiva, mas com pequenos acréscimos marginais. Conclui-se que há uma desaceleração no ritmo de crescimento do gasto social em 2017 e drástica redução em 2018, uma vez que os recursos para financiá-los estão sendo desviados de suas funções de dotar a classe trabalhadora de um sistema de proteção e promoção social.
Desemprego, subutilização, rendimento e informalidade da força de trabalho na região Nordeste
Authors: Gonçalves João de Souza
Published: December 2022

O objetivo principal do trabalho é avaliar a evolução do mercado de trabalho na região Nordeste no período 2012-2018. Os principais resultados encontrados mostram que a região Nordeste apresentou a maior taxa de desocupação e de subutilização da força de trabalho, o menor rendimento do trabalho, a segunda maior taxa de informalidade, e, em geral, a pior distribuição de renda do país. Sendo que as taxas de desocupação, de subutilização da força de trabalho e de informalidade são muito superiores e os rendimentos bem inferiores que a média do país. Constatou-se para os estados da região Nordeste uma relação direta entre o grau de formalização do trabalho e rendimentos. No período 2012-2014, houve uma melhora nos indicadores do mercado de trabalho, entretanto, no período 2015-2018, houve um retrocesso.
PERCEPÇÃO DOS ESTUDANTES DO ENSINO MÉDIO PROFISSIONALIZANTE DE IGUATU-CE SOBRE DA EDUCAÇÃO FINANCEIRA
Authors: Batista Fracisco Sávio Bernardo , Amorim Domingos Isaias Maia
Published: December 2022

A educação financeira é uma ferramenta que as pessoas e a sociedade utilizam para aprimorarem seu conhecimento e administrarem os recursos financeiros da melhor maneira possível. Neste sentido este estudo busca analisar a percepção dos estudantes do ensino médio profissionalizante de Iguatu-CE a respeito deste objeto. A pesquisa consiste em um estudo exploratório e descritivo de origem quanti-qualitativo, com informações coletadas por meio de questionários estruturados e analisados fazendo uso da estatística descritiva. Os resultados indicam que não há uma educação financeira efetiva entre esses estudantes, o que é validado pelos resultados da pesquisa como: parte dos estudantes não são obrigados a explicar aos pais como estão gastando seus recursos financeiros; o conhecimento financeiro proveniente da escola ainda é baixo; os alunos têm adquirido em boa parte, conhecimentos financeiros com pais e parentes, embora haja pouco dialogo no ambiente familiar, pois o principal ponto abordado pelas famílias desses estudantes é estudos e carreiras. Assim, seria de grande valor a participação dos alunos em cursos de curta duração sobre a importância da educação financeira.
CAPITALISMO, CRISE ESTRUTURAL E FLEXIBILIZAÇÃO PRODUTIVA
Authors: Silva Marconi Gomes da , Araújo Denílson da Silva , Duarte Francisco Wellington
Published: December 2022

O artigo analisa as transformações ocorridas no processo de acumulação de capital do pós-Segunda Guerra à década de 1990, evidenciando os efeitos do avanço tecnológico e do emprego de novos métodos produtivos na superação dos momentos de crise da acumulação de capital. Utilizou-se a hipótese de que a superação das crises de acumulação no período analisado foi possível devido ao enfrentamento feito pelo capital na reorganização produtiva através da criação e massificação de novos métodos produtivos a exemplo do fordismo e do Toyotismo e da ação decisiva do Estado. A conclusão foi que a reestruturação produtiva do último quarto do século XX ocorreu aprofundando a terceirização das atividades produtivas em âmbito internacional, se mostrando funcional à retomada do processo de acumulação do capital em detrimento das rendas do trabalho.
ANÁLISE TERRITORIAL DA DESIGUALDADE DE RENDA E DA PROTEÇÃO SOCIAL NO BRASIL
Authors: Trovão Cassiano
Published: December 2022

Este artigo explora o padrão distributivo da renda no Brasil de 2019 em termos regionais, evidenciando desigualdades estruturais, os desafios no enfrentamento da COVID-19 e a centralidade de políticas sociais para sustentação da renda. Procura explicitar que essa desigualdade estrutural tem uma dimensão regional expressiva, o que faz com que o auxílio emergencial tenha uma papel central na sustentação da renda, seja pela maior incidência do PBF ou pela maior informalidade. A crise sanitária global exigiu dos governos, ao redor do mundo, ações emergenciais para amenizar seus impactos para trabalhadores e populações vulneráveis. No Brasil, implementou-se um auxílio emergencial destinado aos trabalhadores informais, desempregados e beneficiários do Programa Bolsa Família. A partir de um recorte territorial, os objetivos deste artigo são: 1) apresentar a condição estrutural da desigualdade de renda corrente no Brasil pré-pandemia; 2) explorar a extensão e a amplitude do aparato de políticas sociais permanente que serviu como um amortecedor, garantindo relativa sustentação da renda; e 3) mapear a proteção social permanente e emergencial nos municípios e estados brasileiros a partir de uma ótica macrorregional, evidenciando sua relevância na mitigação dos impactos negativos dessa crise.
Biblioteca pública na vitrine científica da BRAPCI
Authors: Cardoso Antonio Luiz Mattos de Souza , Miguel Marcelo Calderari
Published: December 2022

A biblioteca pública é potencializadora da cultura da paz, devido às ações inclusivas e sociais; ainda, alinha-se às diretrizes do direito à educação, à cultura, à informação e ao lazer. O objetivo do trabalho é analisar o rol de periódicos sobre biblioteca pública indexados no Acervo de Publicações Brapci no período de 2012 a 2021, de modo a caracterizar essa produção científica e temática no âmbito da Ciência da Informação. A dimensão metodológica delineia-se com a Base Brapci e as técnicas de análise bibliométrica. Situa-se, assim, um estudo descritivo e bibliográfico, realizado em abril de 2022 e que apresenta uma natureza quantitativa dos dados acerca da temática da biblioteca pública na Ciência da Informação. O diagnóstico versa sobre indicadores para: i) realçar a evolução temporal do tema nos últimos 10 anos; ii) o destaque dos períodos científicos que mais acolheram a temática; e, iii) os pesquisadores e as palavras-chave mais representativas. Os resultados recuperam um rol de 550 artigos no acervo Brapci e destacando o ano de 2017 como mais produtivo com 85 publicações, a revista Perspectivas em Ciência da Informação como principal veículo com 31 itens documentais recuperados e, um rol de 227 artigos produzidos por uma equipe de dois estudiosos. A conclusão situa história e memória que cerceiam a biblioteca pública para a democratização informacional e mostra que a instituição é uma esfera de empoderamento e protagonismo social. O estudo ratifica que a temática se mostra pulverizada em torno de 900 pesquisadores e 60 periódicos, situando a primazia e a prospecção cidadã e sociocultural da ambiência pública e necessária à biblioteca.
Análise da gestão da informação em organizações de educação profissional à luz do ambiente informacional de Thomas Davenport
Authors: Guerra Maria Aurea Montenegro Albuquerque , Chaves Italo Teixeira , Cavalcante Luciano Pereira dos Santos
Published: December 2022

A gestão da informação representa uma importante estratégia para as organizações, tanto para seu desenvolvimento interno quanto para sua competitividade. Nesse sentido, o modelo ecológico de informação de Thomas Davenport se torna fundamental em um contexto permeado pela informação nas instituições, sobretudo no meio organizacional. Considerando isso, este estudo objetiva analisar a contemporaneidade do modelo de Thomas Davenport tendo como locus, as organizações de ensino técnico profissionalizante da cidade de Fortaleza-CE. Metodologicamente se configura como uma pesquisa exploratória e descritiva, de abordagem qualitativa, a qual utiliza-se de entrevistas semiestruturadas com os gestores dessas organizações enquanto instrumento de coleta de dados Considera-se nesta etapa o aparato teórico envolvendo os componentes do ambiente informacional e para fins de análise, ancora-se na técnica de análise de conteúdo. Os resultados apontam para a confirmação da atualidade do modelo em sua essência, porém, observou-se um desequilíbrio na aplicabilidade de alguns componentes. Em conclusão, a gestão da informação representa um desafio no ambiente informacional dessas organizações, ocasionado por uma íntima e dependente relação com uma abordagem tecnológica.
Sustainability of Visible Light-Driven Organic Transformations - A Review
Authors: Patel Geetika , Patel Ashok Raj , Banerjee Subhash
Published: December 2022

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The literature survey reveals the applications of visible light as a sustainable energy source in the various constructive organic transformations by using homogeneous and heterogeneous photocatalysts, catalysts under suitable solvents, or under solvent-free conditions to attain green and sustainable chemistry. Recently, the crises of energy sources demand a sustainable and renewable energy source worldwide. In these circumstances, visible lightdriven organic transformations attracted much attention as a good alternative energy source.

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Due to the visible-light-driven organic synthesis offers several advantages such as natural abundance in the solar spectrum, friendly to the equipment, fewer side reactions, costfriendly, selective product formation, higher isolated yields of products, environmental friendliness and sustainability. On the other hand, the developments in chemistry are adopting the green culture, in this state of affairs, visible light will be a great substitute for non-renewable energy sources for chemical transformations and synthesis. It will reduce the consumption of fossil fuels which will lead the world toward achieving the goals of sustainable development.

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A number of different organic molecules are synthesized using different homogeneous and heterogeneous photocatalysts under visible light via different methods such as one-pot multi-component protocol, multi-step method, coupling and condensation method, etc.

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In this review paper, we have highlighted the basics and history of photochemical organic transformations using suitable photo-catalysts and dye-sensitized photochemical reactions. We have presented details of organic transformations under visible light using MOF, nano-material, COF, metal, graphitic carbon, organocatalyst as photocatalysts. We have also highlighted organic transformations using visible light in the absence of any metal or other catalysts. Thus, this review covers wide range of organic reactions under visible light and will benefit the synthetic organic chemist community.
Taste Receptors Function as Nutrient Sensors in Pancreatic Islets: A
Potential Therapeutic Target for Diabetes
Authors: Tian Haoming , Zhang Xiaojuan , Ostrov David A.
Published: December 2022

Glucose, amino acids, and free fatty acids are critical nutrients participating in stimulating
or regulating the hormone secretion of islets. These nutrients are believed to be metabolized
by pancreatic endocrine cells to function. However, recent evidence suggests that taste
receptors, which play key roles in the oral cavity to sense glucose (sweet taste), amino acids
(umami taste), and free fatty acids (fatty taste), are expressed in pancreatic islet cells and may
act to sense these nutrients to regulate pancreatic hormone secretion, including insulin and glucagon.
Disorders in these taste receptor pathways in islets may contribute to the pathogenesis
of diabetes, or it may influence hyperglycemia, disturbance in amino acid metabolism, or hyperlipidemia.
In this review, we su mMarize the expression and hormone-regulating functions
of sweet, umami, and fatty taste receptors acting as nutrient sensors in pancreatic islets in vitro
and in vivo. We discuss the potential roles of these taste receptor-nutrient sensor pathways in
islets targeted to develop therapeutic strategies for diabetes and related disease.
The Paradigm of Disability
Authors: Anggraini Dewi , Anas Muhamad , Wike Wike
Published: December 2022

The aim of this literature study is to catch up on the inclusive development issues in the conception of disability perspective and participation of persons with disabilities in the development goals. This topic is in line with global development which targets seek to accommodate the needs of every citizen including persons with disability to be involved in development. The researcher is using a qualitative approach to construct the conceptual discussion between disability conception and the practice of participation. The data were documented and collected from articles of research that have Indonesian context and legislation. The discussion is described in 4 (four) areas of basic development which are education, health, employment, and accessibility.
Teachers' Efficacy in Inclusive Teaching
Authors: Damayanti Agni , Lintangsari Alies Poetri , Kusumawardani Irene Nany
Published: December 2022

Examining the perceived efficacy of pre-service teachers in implementing inclusive practices is one approach to see if they are up to the challenge. The instrument of the study was adopted from Prof.Umesh Sharma's article. The old research only does qualitative research. This study aims to check pre-service teachers' efficacy in implementing inclusive education in teaching English. This research used a descriptive quantitative research design to check pre-teacher efficacy to practice inclusive classes in teaching English. The data were collected through a questionnaire with 99 participants from introduction in inclusive education classes. The obtained study shows a positive response toward pre-service teachers' efficacy. The findings show that most participants agree with the statements about the efficacy of using inclusive instructions, collaboration, and management. The more strong the sense of efficacy in the pre-service teacher, the greater the chance for them to succeed in implementing inclusive education in the classroom.
Gambaran Pola Asuh terhadap Kepatuhan Diet Anak dan Remaja dengan Diabetes Mellitus: Studi Kasus
Authors: Kusumastuty Inggita , Della Martha Halimatussa’diah  , Catur Saptaning Wilujeng  , Fajar Ari Nugroho
Published: December 2022

Diet merupakan salah satu pilar penatalaksanaan pasien Diabetes Mellitus. Kepatuhan diet pasien penting untuk mengendalikan glukosa darah. Penderita DM tipe 1 yang umumnya menyerang anak-anak dan remaja menghadapi tantangan dalam pengaturan asupan makanan. Orang tua memiliki peran penting dalam membimbing anak-anak mereka untuk mematuhi rekomendasi diet. Penelitian ini bertujuan untuk mengetahui gambaran pola asuh terhadap kepatuhan diet pasien diabetes tipe 1. Penelitian ini merupakan penelitian kualitatif dengan pendekatan studi kasus. Penelitian ini melibatkan empat responden kunci yang diambil sesuai dengan kriteria inklusi yang telah ditentukan. Data dikumpulkan melalui teknik wawancara mendalam. Hasil analisis menunjukkan sebagian besar orang tua menerapkan pola asuh demokratis sedangkan sisanya menerapkan pola asuh otoriter. Tipe orang tua demokratis terlibat dalam mengarahkan, mengingatkan, dan mengawasi sehingga hasilnya adalah pujian yang lebih baik dari pasien. Sedangkan pada tipe orang tua otoriter, pasien cenderung tidak patuh dengan pola makan. Penelitian ini menyimpulkan bahwa pendampingan orang tua dapat menjadi penting dalam mendukung kepatuhan diet pasien DM tipe 1.
Distribusi Isoflavon dan Aktivitas Antioksidan Pada Kecambah Koro Pedang Putih (Canavalia Ensiformis L. (DC))
Authors: Tsalissavrina Iva , Murdiati Agnes , Raharjo Sri , Arsanti Lestari Lily
Published: December 2022

Isoflavon merupakan kelompok senyawa isoflavonoid dengan fungsi fisiologis yang bermanfaat bagi tubuh manusia. Bioaktivitas fisiologis isoflavon berasal dari potensinya sebagai antioksidan dan fungsinya yang bermanfaat bagi kesehatan seperti antikanker, antidiabetes, dan antiinflamasi. Isoflavon dalam bentuk tak terkonjugasi atau aglikon dianggap lebih aktif daripada bentuk glukosida. Sprouting merupakan salah satu metode pengolahan untuk meningkatkan bioavailabilitas isoflavon dengan mengubah isoflavon dari glukosida menjadi bentuk aglikon. Pada penelitian ini profil isoflavon dan aktivitas antioksidan yang dipengaruhi oleh perkecambahan selama 48 jam dilakukan pada bagian kecambah yaitu kotiledon (KTL) dan hipokotil (HPL). Hasil penelitian ini menunjukkan bahwa bagian hipokotil mengandung isoflavon aglikon lebih tinggi daripada bagian kotiledon, terutama daidzein. Aktivitas antioksidan dilakukan dengan metode scavenging radikal DPPH (1,1-diphenyl-2-picrylhydrazyl) untuk ekstrak bagian kecambah seperti kotiledon dan hipokotil. Hipokotil memiliki kapasitas antioksidan tertinggi (nilai IC50 1839,113 ppm), yang secara signifikan lebih baik dari kotiledon dan memiliki perbedaan yang signifikan (p<0,05). Perkecambahan meningkatkan aktivitas antioksidan dan kadar isoflavon yang lebih tinggi di hipokotil, terutama untuk isoflavon daidzein.
Pengaruh Aplikasi Pupuk Kandang Sapi dan PGPR (Plant Growth Promoting Rhizobacteria) pada Pertumbuhan dan Hasil Tanaman Tomat (Solanum lycopersicum L.)
Authors: Sari Dewi Eka , Sudiarso Sudiarso
Published: December 2022

Tomat merupakan salah satu tanaman sayuran buah yang memiliki kandungan gizi dan nilai ekonomis yang tinggi. Penggunaan pupuk anorganik dan pertanian intensif dapat mengakibatkan ketidakseimbangan unsur hara dan mikrobiologi di dalam tanah sedikit. Oleh karena itu, upaya dalam budidaya tanaman tomat dapat menggunakan pupuk kandang sapi dan PGPR. Tujuan dari penelitian ini yaitu untuk mengetahui interaksi antara pupuk kandang sapi dan PGPR pada pertumbuhan dan hasil tanaman tomat. Penelitian dilaksanakan pada bulan Februari hingga Juni 2022. Penelitian ini menggunakan Rancangan Acak Kelompok Faktorial (RAKF) dengan 2 faktor dan 3 ulangan, faktor pertama yaitu 3 taraf dosis pupuk kandang sapi yaitu S1 : dosis pupuk kandang sapi 5 ton ha-1, S2 : dosis pupuk kandang sapi 15 ton ha-1 dan S3 : dosis pupuk kandang sapi 25 ton ha-1 dan faktor kedua yaitu 3 taraf PGPR yaitu P1 : konsentrai PGPR 10 ml L-1, P2 : konsentrasi PGPR 20 ml L-1 dan P3 : konsentrasi PGPR 30 ml L-1. Hasil penelitian menunjukkan bahwa pemberian dosis pupuk kandang sapi dan PGPR menunjukkan adanya interaksi pada parameter pertumbuhan yakni tinggi tanaman dan jumlah daun. Serta pada parameter hasil yakni jumlah buah, fruit set, bobot buah per tanaman, total bobot buah per petak, dan total bobot buah per hektar. Pemberian dosis pupuk kandang sapi 25 ton ha-1 dengan konsentrasi PGPR 30 ml L-1 mampu meningkatkan tinggi tanaman (32,49%), jumlah daun (8,43%), fruit set (70,42%), jumlah buah (14,24%), bobot buah per tanaman (14,21%), bobot buah per petak (14,06%) dan bobot buah per hektar (14,14%).
Empathy matters when speaking with a patient’s family
Authors: McCausland Tammy
Published: December 2022

Nobody wants to receive the dreaded call about a family member in the hospital. But when it happens, healthcare providers should be empathic and communicate with compassion when interacting with family members.
Involvement of the PRL-PAK1 Pathway in Cancer Cell Migration
Authors: CARRASCO-CEBALLOS JESSICA MARIANA , BARRERA-HERNÁNDEZ DAVID , LOCIA-ESPINOSA JOSÉ , SAMPIERI CLARA LUZ , LARA-REYES JESÚS ANTONIO , HERNÁNDEZ-AGUILAR MARÍA ELENA , ARANDA-ABREU GONZALO EMILIANO , TOLEDO-CÁRDENAS MARÍA REBECA , CHI-CASTAÑEDA LIZBETH DONAJÍ , PÉREZ-ESTUDILLO CESAR ANTONIO , ROJAS-DURÁN FAUSTO
Published: December 2022

Prolactin (PRL) is a polypeptide hormone synthesized in the lactotrophs of the adenohypophysis and in extrahypophyseal glands (such as the prostate and breasts) where it promotes their development. PRL is also involved in cancer development in these glands. It has been shown to stimulate cancer cell migration, suggesting its possible involvement in metastasis, in which cell migration plays an essential role. However, the role of PRL in cell migration is still unclear. Moreover, the intracellular mechanisms activated by PRL to carry out cell migration are less well understood. PRL exerts its effects via the PRL receptor (PRLR), which leads intracellularly to phosphorylation of Janus protein kinase 2 (JAK2), which in turn phosphorylates p21-activated protein kinase (PAK1), leading to an increase in cell migration. Although several studies have described the involvement of the PRL-PAK1 pathway in breast cancer cell migration, the molecular mechanisms have not been fully elucidated and there is no integration of these into signaling pathways. This study was conducted based on literature search of review articles and original research in the PubMed database, using the following keywords: PRL, cell migration, PRL and cell migration, PAK1 and signaling pathways. The aim of this review article was to describe the major signaling pathways controlled by PRL-PAK1 and propose a comprehensive model of the signaling pathways associated with PRL-PAK1.
Metastasis of a Solitary Fibrous Tumor in the Mandible: A Case Report
Authors: DUDDE FLORIAN , GIESE MANFRED , HENKEL KAI-OLAF
Published: December 2022

Background/Aim: The solitary fibrous tumor (SFT) is a mesenchymal neoplasm and belongs to the group of soft tissue sarcomas. The SFT is characterized by indolent, slowly progressive growth and manifests itself clinically by compression of neighboring structures. The treatment of choice is surgical removal of the tumor. In advanced stages, there is also the possibility of chemotherapy, systemic therapy, or immunotherapy, as well as radiotherapy. Depending on their location and severity, SFTs show different recurrence rates and survival functions. Case Report: The present case report shows an extremely rare localization of a low-risk SFT in the floor of the mouth. Despite complete surgical removal of the SFT, the patient showed a metastasis of the SFT in the mandible two years postoperatively. Therefore, this case report shows that even a low-risk SFT in the localized stage can metastasize despite of total surgical removal. Consequently, SFTs of the head and neck region require close clinical and imaging follow-up. Conclusion: Although the localization of the SFT in the oral cavity is a rarity, this entity should be included in the differential diagnosis in the case of long-term space-occupying processes in the head and neck region. This report is the first regarding metastasis of a SFT to the mandible.
A Case of Intraocular Metastasis of Lung Cancer Diagnosed Using Cell Block Preparation of the Vitreous Humor
Authors: MATSUMOTO KOHEI , KASE SATORU , NAMBA KENICHI , IWATA DAIJU , MATSUNO YOSHIHIRO , ISHIDA SUSUMU
Published: December 2022

Background/Aim: Masquerade syndrome is characterized by uveitis-like manifestations caused by tumor cell infiltration into the ocular tissues. The aim of the study was to report a lung cancer patient with persistent unilateral vitreous opacity, who was eventually diagnosed with masquerade syndrome using cell block preparation. Case Report: An 82-year-old female complained of blurred vision in her left eye (OS). Because of pulmonary adenocarcinoma, she had previously received anticancer drug treatment at another Hospital and achieved partial remission. Ophthalmic examinations revealed anterior chamber inflammation and vitreous opacity OS. Corticosteroid eye drops were administered, but the inflammation did not improve, and was referred to the Hokkaido University Hospital. The left best-corrected visual acuity was 0.1 with normal intraocular pressure. Anterior chamber inflammation was 2+ cells, and vitreous haze was 4+ OS. B-mode ultrasonography showed diffuse heterogeneous high echoic changes in the vitreous cavity. She underwent vitrectomy, and cell block preparation of the vitreous infusion fluids was performed. Cytopathology revealed adenocarcinoma cells with a high nuclear/cytoplasmic ratio and glandular formation. The immunocytochemical study showed that tumor cells were positive for thyroid transcription factor-1 (TTF-1), napsin A, and CK7, therefore diagnosis of masquerade syndrome due to intraocular metastasis of pulmonary adenocarcinoma was reached. Chemoradiotherapy was administered, and the eye got phthisis bulbi after irradiation 2 years after diagnosis. Conclusion: Cell block preparation using vitreous humor may be useful in the diagnosis and management of intraocular metastasis of pulmonary adenocarcinoma in patients with prolonged vitreous opacity.
COĞRAFİ BİLGİ SİSTEMİ TABANLI ANALİTİK HİYERARŞİ SÜRECİ KULLANILARAK TAŞKIN TEHLİKE HARİTALAMASI
Authors: KARAKUŞ Can Bülent , CEYLAN Şeyma
Published: December 2022

Bu çalışmanın amacı; çalışma alanı olarak seçilmiş olan Sivas kent merkezi ve yakın çevresinin taşkın riskini ortaya koymaktır. Çalışmada taşkın risk haritalaması için 8 adet kriter (eğim, yükseklik, bakı, yağış, büyük toprak grubu, akarsulara uzaklık, litoloji ve arazi kullanımı) seçilmiştir. Bu kriterler çok kriterli karar verme yöntemlerinden olan Analitik Hiyerarşi -Süreci (AHS) yöntemi temelinde Coğrafi Bilgi Sistemi (CBS) kullanılarak analiz edilmiş ve taşkın açısından riskli alanlar belirlenmiştir. AHS yöntemi kapsamında taşkın tehlike haritalamasında dikkate alınan kriterler için CR (Tutarlılık) değeri 0.03 olarak hesaplanmış olup, bu değer elde edilen sonuçların tutarlı ve kabul edilebilir olduğunu göstermiştir. Yöntem çerçevesinde oluşturulmuş olan taşkın tehlike haritasının ortaya koyduğu risk kategorileri “çok yüksek (% 12.72)”, “yüksek (% 24.40)”, “orta (% 28.14)”, “düşük (% 25.40)” ve “çok düşük (% 11.32)” şeklinde 5 farklı sınıf ile temsil edilmiştir. Çalışma alanındaki yerleşim alanlarının bir kısmı (% 25.20) ile tarım alanlarının bir kısmı (% 47.28), taşkın riski açısından “çok yüksek” riskli alanlar kategorisinde yer almıştır. Elde edilen sonuçlar; taşkın risklerinin azaltılmasında CBS tabanlı AHS yönteminin karar vericilere oldukça faydalar sağlayabileceğini göstermiştir. Taşkın risklerinin azaltılmasına yönelik olarak taşkın risk verileri kent planlarına yansıtılmalı ve plan uygulamalarına taşkın riskinin derecesine göre öncelik verilmelidir.
A THEORETICAL INVESTIGATION ON TRAINING OF PIPE-LIKE NEURAL NETWORK BENCHMARK ARCHITECTURES AND PERFORMANCE COMPARISONS OF POPULAR TRAINING ALGORITHMS
Authors: İMİK ŞİMŞEK Özlem , ALAGÖZ Barış Baykant
Published: December 2022

Architectures of neural networks affect the training performance of artificial neural networks. For more consistent performance evaluation of training algorithms, hard-to-train benchmarking architectures should be used. This study introduces a benchmark neural network architecture, which is called pipe-like architecture, and presents training performance analyses for popular Neural Network Backpropagation Algorithms (NNBA) and well-known Metaheuristic Search Algorithms (MSA). The pipe-like neural architectures essentially resemble an elongated fraction of a deep neural network and form a narrowed long bottleneck for the learning process. Therefore, they can significantly complicate the training process by causing the gradient vanishing problems and large training delays in backward propagation of parameter updates throughout the elongated pipe-like network. The training difficulties of pipe-like architectures are theoretically demonstrated in this study by considering the upper bound of weight updates according to an aggregated one-neuron learning channels conjecture. These analyses also contribute to Baldi et al.'s learning channel theorem of neural networks in a practical aspect. The training experiments for popular NNBA and MSA algorithms were conducted on the pipe-like benchmark architecture by using a biological dataset. Moreover, a Normalized Overall Performance Scoring (NOPS) was performed for the criterion-based assessment of overall performance of training algorithms.
FARKLI ALTTAŞ BİRİKTİRME SICAKLIKLARINDA KAPLANMIŞ NİTİ KAPLAMALARIN TRİBOLOJİK ÖZELLİKLERİNİN İNCELENMESİ
Authors: POYRAZ Mehmet
Published: December 2022

Ticari saf titanyum; dental ve ortopedik uygulamalarda yaygın olarak tercih edilen, hafif, biyouyumlu, yüksek mukavemetli ve korozyona dayanıklı bir implant malzemesidir. Bu çalışmanın amacı; dental implant malzemelerinden ticari saf titanyumun metallerle temasında göstermiş olduğu yüksek kararsız sürtünme katsayılarını önlemek ve malzemenin sürtünme, aşınma özelliklerinin iyileştirilmeye çalışılmasıdır. Bu maksatla Ti alttaş numunelere farklı biriktirme sıcaklıklarında RF magnetron saçtırma yöntemi kullanılarak NiTi film kaplamalar uygulanmıştır. NiTi kaplamaların kaplama malzemesi olarak seçilmesinin sebebi; literatür incelemelerinde bu kaplamaların uygulanan stresi elastik deformasyona dönüştürebilmesi, düşük sertlik, yüksek mukavemet vermesi ve implant malzemeleri üzerinde biyouyumlu ve yapışkan olduğunun gösterilmesidir. Kaplamalar sonrası Taramalı Elektron Mikroskobunun EDS dedektörü kullanılarak filmlerin yüzeyinden kimyasal kompozisyonlar belirlenmiştir. XRD cihazı kullanılarak farklı alttaş biriktirme sıcaklıklarında biriktirilen filmlerin X-Işınları kırınım ölçümleri gerçekleştirilmiştir. NiTi film kaplamaların sürtünme katsayısı ve aşınma oranlarının alttaş biriktirme sıcaklıklarındaki değişimle nasıl etkilendiğini belirlemek için, nano tribometre aşınma cihazında bu filmler teste tabii tutulmuştur.
APPLICATION OF REBA AND KARAKURI KAIZEN TECHNIQUES TO REDUCE ERGONOMIC RISK LEVELS IN A WORKPLACE
Authors: GÜRSOY ÖZCAN Aynur
Published: December 2022

Repetitive works and the works done with inappropriate body postures cause musculoskeletal disorders and workforce losses. Design, technology, and humans must come together in ergonomic conditions. In this study, the ergonomic risk levels that employees in automotive production lines being exposed to were determined by the rapid entire body assessment (REBA) method and by considering anthropometric measurements and ergonomic body postures at a line with high risk level, and a shelf system was designed in accordance with the Karakuri working principle. Through the computer-aided design, the system operation was simulated and solutions for ergonomic risks could be provided before the production. The ergonomic risk level, which was “high” in the current situation, could be reduced with the newly designed mechanism, and an ergonomic workspace could be provided for employees. In the new situation, the ergonomic risk level is “low.” In addition to ergonomic improvements, as the manual transportation works of the employee were eliminated, the cycle time of the line, which was 120 s in the first state, was reduced to 100 s after the use of the Karakuri mechanism and the efficiency of the line increases by 17%.
Remote Testing Apps for Multiple Sclerosis Patients: Scoping Review of Published Articles and Systematic Search and Review of Public Smartphone Apps
Authors: Michaud Jacob B , Penny Cameron , Cull Olivia , Hervet Eric , Chamard-Witkowski Ludivine
Published: December 2022

Background

Many apps have been designed to remotely assess clinical status and monitor symptom evolution in persons with multiple sclerosis (MS). These may one day serve as an adjunct for in-person assessment of persons with MS, providing valuable insight into the disease course that is not well captured by cross-sectional snapshots obtained from clinic visits.

Objective

This study sought to review the current literature surrounding apps used for remote monitoring of persons with MS.

Methods

A scoping review of published articles was conducted to identify and evaluate the literature published regarding the use of apps for monitoring of persons with MS. PubMed/Medline, EMBASE, CINAHL, and Cochrane databases were searched from inception to January 2022. Cohort studies, feasibility studies, and randomized controlled trials were included in this review. All pediatric studies, single case studies, poster presentations, opinion pieces, and commentaries were excluded. Studies were assessed for risk of bias using the Scottish Intercollegiate Guidelines Network, when applicable. Key findings were grouped in categories (convergence to neurological exam, feasibility of implementation, impact of weather, and practice effect), and trends are presented. In a parallel systematic search, the Canadian Apple App Store and Google Play Store were searched to identify relevant apps that are available but have yet to be formally studied and published in peer-reviewed publications.

Results

We included 18 articles and 18 apps. Although many MS-related apps exist, only 10 apps had published literature supporting their use. Convergence between app-based testing and the neurological exam was examined in 12 articles. Most app-based tests focused on physical disability and cognition, although other domains such as ambulation, balance, visual acuity, and fatigue were also evaluated. Overall, correlations between the app versions of standardized tests and their traditional counterparts were moderate to strong. Some novel app-based tests had a stronger correlation with clinician-derived outcomes than traditional testing. App-based testing correlated well with the Multiple Sclerosis Functional Composite but less so with the Expanded Disability Status Scale; the latter correlated to a greater extent with patient quality of life questionnaire scores.

Conclusions

Although limited by a small number of included studies and study heterogeneity, the findings of this study suggest that app-based testing demonstrates adequate convergence to traditional in-person assessment and may be used as an adjunct to and perhaps in lieu of specific neurological exam metrics documented at clinic visits, particularly if the latter is not readily accessible for persons with MS.
Anti‐diabetic effect of andrographolide from Sambiloto herbs (Andrographis paniculata (Burm.f.) Nees) through the expression of PPARγ and GLUT‐4 in adipocytes
Authors: Astuti Novia Tri , Novitasari Putri Rachma , Tjandrawinata Raymond , Nugroho Agung Endro , Pramono Suwijiyo
Published: December 2022

Andrographolide has been shown to have a pharmacological effect as an antidiabetic. Nevertheless, the comprehensive mechanism of action has yet to be determined. Andrographolide is a primary component of the sambiloto herb (Andrographis paniculata (Burm.f.) Nees), in which a simple isolation process can obtain high yields. This study aimed to explain the anti‐diabetic effect of andrographolide compared to pioglitazone (a positive control) on glucose uptake by measuring the expression levels of peroxisome proliferator‐activated receptor gamma (PPARγ) and glucose transporter type 4 (GLUT‐4) genes in 3T3‐LI mouse adipocytes as an in vitro model. The differentiation of mature adipocytes from 3T3‐L1 fibroblasts was induced with 3‐isobutyl‐1‐methylxanthine, dexamethasone, and insulin. Andrographolide was provided through direct isolation from A. paniculata herbs. The gene expression was detected using the reverse transcription‐polymerase chain reaction (RT‐PCR). Pioglitazone and andrographolide significantly increased glucose uptake capability. Andrographolide was able to increase the mRNA levels of PPARγ and GLUT‐4 compared to pioglitazone with the best concentration at 5.6 µM. In conclusion, andrographolide can improve glucose uptake by increasing mRNA levels of PPARγ and GLUT‐4 that encodes protein, which are key factors for glucose homeostasis. Therefore, this finding further establishes the potency of andrographolide from A. paniculata as an antidiabetic.
Efektivitas Mobilisasi Sendi dan Pelatihan Stabilisasi Lumbopelvis pada Non-Specific Low Back Pain
Authors: Nugraha Made Hendra Satria , Antari Ni Komang Ayu Juni , Dewi Anak Ayu Nyoman Trisna Narta
Published: December 2022

Latar Belakang: Non-specific low back pain merupakan tipe nyeri muskuloskeletal yang sering dilaporkan. Permasalahan yang biasanya menyertai non-specific low back pain di antaranya adalah keterbatasan gerak sendi lumbopelvis, nyeri, serta disabilitas punggung bawah. Terdapat beberapa penanganan yang dapat diberikan untuk memperbaiki gerak dan fungsi pada non-specific low back pain,yaitu melalui pemberian modalitas elektroterapi, terapi latihan, serta manual terapi.Tujuan: Membandingkan efektivitas penambahan mobilisasi sendi dan pelatihan stabilisasi lumbopelvis (Mostab) pada penanganan standar fisioterapi berupa intervensi ultrasound therapy (UST) dan pelatihan peregangan dalam menurunkan disabilitas punggung bawah.Metode: Penelitian ini adalah penelitian eksperimental dan peserta penelitian dibagi secara acak ke dalam 2 kelompok. Kelompok kontrol (n=12) diberikan UST + pelatihan peregangan, sedangkan kelompok perlakuan (n=12) diberikan UST + pelatihan peregangan + Mostab. Alat ukur evaluasi terapi yang digunakan adalah modified oswestry disability index versi Indonesia (MODI).Hasil: Hasil uji komparasi antar kelompok didapatkan nilai yang signifikan (p=0,000) antarkedua kelompok. Penambahan Mostab pada intervensi ultrasound therapy dan pelatihan peregangan lebih signifikan daripada kombinasi ultrasound therapy dan pelatihan peregangan saja dalam menurunkan disabilitas pungggung bawah pada non-specific low back pain.Kesimpulan: Mostab efektif dalam menurunkan disabilitas pungggung bawah pada non-specific low back pain.