bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasonographic evaluation of the adrenal glands in six dogs with hypoadrenocorticism
Authors: Hoerauf A , Reusch C
Published: September 2014

The purpose of this study was to determine the value of ultrasonographic characterization of the adrenal glands in dogs with hypoadrenocorticism. Measurements of adrenal glands were obtained in six dogs with hypoadrenocorticism. The adrenal glands on both sides were shorter (range: left adrenal gland length, 10.0 to 19.7 mm; right adrenal gland length, 9.5 to 18.8 mm) and thinner (range: left adrenal gland thickness, 2.2 to 3.0 mm; right adrenal gland thickness, 2.2 to 3.4 mm) than in normal dogs (range: left adrenal gland length, 13.2 to 26.3 mm; right adrenal gland length, 12.4 to 22.6 mm; left adrenal gland thickness, 3.0 to 5.2 mm; right adrenal gland thickness, 3.1 to 6.0 mm). Statistical analysis revealed a significant reduction in size of the left adrenal gland (p less than 0.05) in dogs with hypoadrenocorticism compared to the left adrenal gland in normal dogs. The results of this study show that atrophy of the adrenal glands in dogs with hypoadrenocorticism seems to lead to an ultrasonographic-measurable reduction in size of the adrenal glands.
Nonresponsive generalized bacterial infection associated with systemic lupus erythematosus in a Beauceron
Authors: Clercx C , McEntee K , Gilbert S , Michiels L , Snaps F , Jacquinet E , Desmecht D , Henroteaux M , Bernadina WE
Published: September 2014

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies.
Reflex sympathetic dystrophy in a dog
Authors: LaBarre A , Coyne BE
Published: September 2014

Reflex sympathetic dystrophy is a well-recognized syndrome in human patients following injury to an extremity. The syndrome may include hyperesthesia and autonomic changes. The autonomic changes are initial vasodilatation followed by vasoconstriction (e.g., edema followed by cyanosis, and cool skin); hyper- or hypohydrosis; atrophic changes in the skin, subcutis, and muscles; and osteoporosis. Early treatment with a short course of steroids and infiltration of the painful site with lidocaine may alleviate symptoms. If that fails, sympathetic ganglionic block with lidocaine (and possibly steroids) or surgical sympathectomy may provide resolution. A case of reflex sympathetic dystrophy in a dog is presented, involving bilateral distal hind-limb edema and hyperesthesia.
Sensory polyganglioradiculoneuritis in a dog
Authors: Chrisman CL , Platt SR , Chandra AM , deLahunta A , Shelton GD
Published: September 2014

Generalized reduction of nociception and conscious and unconscious proprioception were found in an approximately eight-year-old, male, Maltese mixed-breed dog presented for difficulty prehending food and experiencing ataxia of three months duration. Results of needle electromyogram, motor nerve conduction velocity, and cerebrospinal fluid analysis were normal. A diagnosis of sensory polyneuropathy was suspected. No underlying cause could be determined. Neurological signs progressed to quadriparesis over the following four months despite treatment attempts with prednisone and procarbazine. Necropsy confirmed a sensory polyganglioradiculoneuritis, but no inciting cause could be established.
Prolapse of the gland of the third eyelid in a cat: a case report and literature review
Authors: Schoofs SH
Published: September 2014

A one-year-old, castrated male, domestic shorthair was presented with a prolapse of the gland of the third eyelid. Similar to the dog, this cat did not appear to suffer from this eye condition. The prolapse was unilateral on the left eye. The right eye was normal. No accompanying eye diseases were found. Treatment consisted of a surgical pocket technique similar to the technique used in dogs.
Surgical repair of nasopharyngeal stenosis in a cat using a stent
Authors: Novo RE , Kramek B
Published: September 2014

An intraluminal stent was used to maintain patency of a recurrent nasopharyngeal stenosis (NPS) in a cat. The stenotic membrane within the nasopharynx was resected, and a 2-cm long, braided-wire endoprosthesis was placed as a stent. The patient was evaluated at one day, six weeks, 19 weeks, and 49 weeks following surgery. The cat tolerated the stent well. The 19-week recheck revealed granulation tissue partially obstructing the pharyngeal aspect of the stent which was subsequently surgically resected. Complications after excision of the granulation tissue included intermittent upper respiratory congestion and nasal discharge. The 49-week recheck showed no increased granulation tissue; however, upper respiratory congestion was still present. This particular stent, and its use as described in this paper, is recommended in cases of chronic recurrent NPS.
Echocardiographic measurements in the Irish wolfhound: reference values for the breed
Authors: Vollmar AC
Published: September 2014

Out of 400 Irish wolfhounds cardiologically examined, echocardiographic measurements of 262 normal dogs were analyzed to obtain reference values for the breed. Based on regression analysis, several echocardiographic parameters showed significant linear correlation with body weight and with age, but coefficients of determination were low. Therefore, due to a high individual variability of echocardiographic measurements in adult Irish wolfhounds, the predictive value of body weight for echocardiographic measurements was clinically not relevant. Sex had no influence on echocardiographic values. For the estimation of myocardial function, end-systolic volume index (ESVI) (mean, 29.0 ml/m2 +/- standard deviation [SD], 5.9 ml/m2) was determined for the group of 262 normal dogs.
Pulsed Doppler assessment of left ventricular diastolic function in normal and cardiomyopathic cats
Authors: Bright JM , Herrtage ME , Schneider JF
Published: September 2014

Left ventricular (LV) diastolic function was evaluated in 16 cats with primary hypertrophic cardiomyopathy (HCM) using pulsed Doppler (PD) assessment of transmitral flow and isovolumic relaxation time. Data obtained was compared to data from 12 healthy, adult, research cats. Compared to normal cats, the HCM group showed significantly (p value less than 0.05) reduced early LV inflow velocities (mean +/- standard error [SE], peak velocity of 0.70+/-0.04 m/s versus 0.54+/-0.04 m/s and integrated velocity of 0.48+/-0.08 m/s versus 0.37+/-0.03 m/s); a reduced rate of deceleration of early inflow (mean+/-SE, -12.0+/-1.0 m/s2 versus -5.1+/-1.1 m/s2); prolonged isovolumic relaxation time (mean +/- SE, 45.7+/-3.3 ms versus 76.0+/-3.1 ms); and increased atrial systolic flow velocities (mean +/- SE, peak velocity of 0.29+/-0.04 m/s versus 0.48+/-0.04 m/s and integrated velocity of 0.21+/-0.03 m/s versus 0.34+/-0.03 m/s). The results suggest that PD provides a noninvasive method of identifying and quantifying functional diastolic impairment in cats with HCM.
Hypertrophic cardiomyopathy in a litter of five mixed-breed cats
Authors: Kraus MS , Calvert CA , Jacobs GJ
Published: September 2014

A litter of five, 18-month-old, mixed-breed cats were determined to have hypertrophic cardiomyopathy (HCM). Although no overt clinical signs were present in any cat, systolic heart murmurs were present in each. Electrocardiograms were normal, while subjective interpretations of heart enlargement on radiographs were made on four cats. Echocardiographic analyses indicated abnormalities consistent with HCM. Overt clinical signs are absent two years following diagnosis.
Treatment of aggressive testicular tumors in four dogs
Authors: Dhaliwal RS , Kitchell BE , Knight BL , Schmidt BR
Published: September 2014

In this report, the authors describe four dogs referred for diagnosis and treatment of unusual and aggressive testicular tumors. For the vast majority of dogs with testicular tumors, orchiectomy is curative. All dogs in this report had surgical resection, and three of four dogs were treated with cisplatin chemotherapy. Cisplatin is widely recognized as the most active agent in testicular cancer in human medicine.
Functional outcome in dogs after surgical treatment of caudal lumbar intervertebral disk herniation
Authors: Dhupa S , Glickman NW , Waters DJ
Published: September 2014

Caudal lumbar disk herniations (i.e., third lumbar [L3] to seventh lumbar [L7] intervertebral spaces) represent approximately 15% of surgically treated thoracolumbar disk herniations in dogs. A retrospective case-control study was conducted to determine the postoperative outcome of this subset of dogs in the authors' neurosurgical practice. Medical records (1985 through 1996) were reviewed for dogs with caudal lumbar disk herniation confirmed at surgery. Thirty-six cases were identified. For each case, two dogs that underwent surgical treatment for upper motor neuron thoracolumbar disk herniation (tenth thoracic [T10] to L3 intervertebral spaces) were selected as controls. Probabilities of functional recovery for cases and controls were 81% and 85%, respectively (p value of 0.49). In dogs with caudal lumbar disk herniation, complete sensorimotor loss was the only significant predictor of functional recovery (p value of 0.005). Disk herniations that occur at the thoracolumbar junction and those that occur in the caudal lumbar region should not be considered to be different in terms of surgical treatment and postoperative outcome. The lower motor neuron signs that often accompany caudal lumbar disk herniation reflect the site of spinal cord injury and do not necessarily predict a poor prognosis.
Bone dysplasias in the labrador retriever: a radiographic study
Authors: Morgan JP , Wind A , Davidson AP
Published: September 2014

A radiographic study of the humeral head, elbow joint, hip joint, stifle joint, tarsal joint, and lumbosacral (LS) junction was performed in 1,018 Labrador retrievers in search for humeral head, femoral condyle, and tarsal osteochondroses; elbow and hip dysplasias; and transitional LS vertebrae. The ages of all dogs reported were one year or older. Elbow dysplasia was detected as the most common lesion (17.8%), with a higher prevalence in the male dog. Hip dysplasia was the second most common lesion (12.6%) and was found equally in the male and female. Elbows and hips were often affected in the same dog (4.2%). Transitional vertebral segments were found more frequently in the female (4.2%) than in the male (1.0%), and the condition was thought to be inherited.
Determination of optimal time for mating by artificial insemination with chilled semen using luteinizing hormone surge as an indicator in beagles
Authors: Nishiyama T , Kinugasa T , Kimura T , Watanabe G , Taya K , Tsumagari S , Takeishi M
Published: September 2014

Artificial insemination (AI) was conducted using the second fraction of semen, which was collected from 15 male dogs, diluted to a total sperm count of 100x10(6) for each insemination with egg-yolk Tris (eyT) citrate acid buffer and incubated at 4 degrees C for 48 hours. Luteinizing hormone (LH) surge was detected to determine the optimal time for mating using canine LH assay kits. Artificial insemination using 100x10(6) sperm was performed on the fourth and sixth days or the fifth and seventh days after the LH surge. The conception rates were 33% (4/12) and 89% (8/9), respectively; the whelping rates also showed similar results. Serum LH and follicle stimulating hormone (FSH) concentrations were measured in nine dogs, and the mean LH concentration (+/- standard deviation) at LH surge was 15.77+/-7.66 ng/ml. The time of the LH surge detected by the canine LH assay kit was very similar to that measured by radioimmunoassay (RIA).
Immune-mediated hemolytic anemia: 70 cases (1988-1996)
Authors: Reimer ME , Troy GC , Warnick LD
Published: September 2014

Survival times and mortality rates in dogs with idiopathic immune-mediated hemolytic anemia (IMHA) have been infrequently reported in the literature. This study evaluates survival and mortality in a large group of dogs with IMHA. The association of age, sex, and breed with IMHA was evaluated by comparing affected dogs to control dogs admitted to the hospital during the same time period. Treatment regimens were reviewed to determine the effects of different agents upon survival of dogs with IMHA during hospitalization and after discharge. Median survival times for each treatment group were 57 days (prednisone), 28 days (prednisone, cyclophosphamide), 974 days (prednisone, azathioprine), 15 days (prednisone, cyclophosphamide, azathioprine), and one day (no treatment). Overall mortality rate in the population of dogs studied was 70%. Twenty-nine (41.4%) dogs either died or were euthanized while hospitalized. Forty-one (59%) dogs were discharged from the hospital. Of the dogs discharged, 10 died within the first month, another five died within three months, and another five died within a year of discharge due to assumed complications of therapy or relapses of IMHA.
Cryptosporidiosis, coccidiosis, and total colonic mucosal collapse in an immunosuppressed puppy
Authors: Willard MD , Bouley D
Published: September 2014

An eight-week-old puppy with chronic diarrhea was diagnosed with simultaneous opportunistic pathogens (i.e., cryptosporidiosis, coccidiosis) and total colonic mucosal collapse. Lack of lymphoid follicles in the spleen and lymph nodes suggested a primary underlying immunosuppression that most likely permitted infection with these pathogens. Intensive antibiotic therapy was most likely responsible for the severe colonic lesion, and bismuth subsalicylate administration in this severely dehydrated puppy may have contributed to renal failure as the ultimate cause of death.
Potential central nervous system complications of von Willebrand's disease
Authors: Applewhite AA , Wilkens BE , McDonald DE , Radasch RM , Barstad RD
Published: September 2014

Three Doberman pinschers were presented on emergency referral for progressive neurological deficits. All three dogs had a similar onset of clinical signs associated with an apparently minor traumatic event. Each dog progressed to significant neurological dysfunction including paraplegia, tetraplegia, and/or loss of deep pain sensation. None of the animals was apparently affected by cervical vertebral instability ("Wobbler's Syndrome"). All were confirmed to have von Willebrand's disease. In all cases, significant epidural hemorrhage was identified. The etiology of each hemorrhage, however, was different for each animal. The cases presented here demonstrate a potential relationship between neurological deficits and the patient's ability to effectively coagulate blood. Hemostatic abnormalities, such as von Willebrand's disease, should be included as possible differential diagnoses or contributing factors in animals demonstrating neurological deficits. These abnormalities should especially be considered following trauma, intervertebral disk extrusion, or spinal surgery.
Computed tomographic findings of ceroid lipofuscinosis in a dog
Authors: Franks JN , Dewey CW , Walker MA , Storts RW
Published: September 2014

A two-year and seven-month-old, castrated male border collie was presented for a two-month history of progressive neurological signs including blindness, ataxia, dementia, and partial seizures. A complete blood count, serum biochemical profile, urinalysis, thoracic radiographs, and cerebrospinal fluid analysis were within reference ranges. Computed tomography (CT) of the brain showed dilatation of the ventricles and atrophy of the cerebral cortex. A central nervous system (CNS) storage disease was suspected, and the dog was euthanized due to a poor prognosis. Light and electron microscopic examination revealed neuronal degeneration with pigment accumulation in neurons of the CNS, in ganglia of the peripheral nervous system, and in several non-nervous tissues. Ceroid lipofuscinosis was diagnosed based on the microscopic and ultrastructural lesions detected. This is the second report of CT findings in a canine clinical patient with ceroid lipofuscinosis.
Nasopharyngeal diseases in cats: a retrospective study of 53 cases (1991-1998)
Authors: Allen HS , Broussard J , Noone K
Published: September 2014

The records of 53 cats with nasopharyngeal disease were examined. Of the cats with nasopharyngeal disease, 49% had lymphosarcoma and 28% had polyps. Clinical signs in these cats were compared to 24 cats with nasal disease alone. Cats with only nasal disease more commonly had historical nasal discharge and sneeze, whereas cats with nasopharyngeal disease more often had stertorous respiration, phonation change, and typically reported less nasal discharge or sneeze. It is important to include nasopharyngeal disease in the differential diagnosis for cats with nasal discharge, sneeze, stertor, or phonation change.
Idiopathic thrombocytopenic purpura in a cat
Authors: Garon CL , Scott MA , Selting KA , Cohn LA
Published: September 2014

An 11-year-old, castrated, male domestic shorthair cat was presented for hematuria and pollakiuria. The cat had a marked thrombocytopenia, and a bone-marrow core biopsy demonstrated megakaryocytic hyperplasia with many megakaryocyte-associated neutrophils (i.e., emperipolesis). On peripheral blood, collected at initial presentation, what appeared to be platelets were noted to be within or adherent to occasional neutrophils. The thrombocytopenia was idiopathic in that no definitive cause could be found. However, platelet concentrations appeared to increase and decrease in response to changes in prednisone and cyclosporine therapy, suggesting a possible immune-mediated pathogenesis. As tests to detect increased feline platelet-associated antibodies are unavailable, immune-mediated thrombocytopenia can only be tentatively diagnosed in cats by exclusion and response to therapy.
Long-term case study of myelodysplastic syndrome in a dog
Authors: Miyamoto T , Horie T , Shimada T , Kuwamura M , Baba E
Published: September 2014

A 10-year-old, female shih tzu was diagnosed as having myelodysplastic syndrome (MDS) based on the presence of a nonregenerative anemia, dysplastic changes in the three hematopoietic cell lines, a normal to hypercellular bone marrow, and less than 30% blast cells of all nucleated cells in the bone marrow. Low-dose aclarubicin, a differentiation-induction therapy for MDS and atypical leukemias in humans, was administered. Hematological improvement was observed, and the dog lived for 809 days after the first presentation.
Invasive multiple lymphangiomas in a young dog
Authors: Belanger MC , Mikaelian I , Girard C , Daminet S
Published: September 2014

An unusual case of multiple lymphangiomas with lymph node involvement is described. A seven-month-old, spayed female golden retriever was presented with a myriad of cystic masses in the inguinal and caudal mammary regions. She was diagnosed with congenital lymphangiomas (i.e., lymphatic hamartomas). As in human lymphangiomas, lymphatic endothelial cells expressing factor VIII-related antigen and smooth muscle were present in this case. A literature search did not identify similar characteristics in other reported canine lymphangiomas. The dog was treated surgically and had a recurrence. Following a second surgical intervention, she is now disease-free.
A two-dimensional analysis of limb symmetry in the trot of Labrador retrievers
Authors: Gillette RL , Zebas CJ
Published: September 2014

Sixteen sound Labrador retriever and Labrador retriever cross-breed adult dogs were evaluated for symmetry while in a trot gait using a two-dimensional motion analysis system. Reflective markers were placed at selected joint centers. Each dog had the right side and then the left side videotaped while in the trot gait. The markers on the videotape were then digitized for analysis. There was no significant difference (p less than 0.05) between the movements of the two sides. It was concluded that the trot gait is symmetrical and that a two-dimensional system can be used to analyze gait in the dog.
Syringohydromyelia in Cavalier King Charles spaniels
Authors: Rusbridge C , MacSweeny JE , Davies JV , Chandler K , Fitzmaurice SN , Dennis R , Cappello R , Wheeler SJ
Published: September 2014

Syringohydromyelia secondary to foramen magnum overcrowding is described in seven Cavalier King Charles spaniels. Clinical signs were consistent with a central spinal cord lesion. The most common signs were persistent scratching at the shoulder region with apparent neck, thoracic limb, or ear pain and thoracic limb lower motor neuron deficits. The diagnosis was made by magnetic resonance imaging. The syringohydromyelia is postulated to be a consequence of an occipital bone malformation resulting in a small caudal fossa and cerebellar herniation. Clinical signs improved but did not completely resolve when the dogs received treatment with corticosteroids or nonsteroidal anti-inflammatory drugs.
A modified bilateral transfrontal sinus approach to the canine frontal lobe and olfactory bulb: surgical technique and five cases
Authors: Glass EN , Kapatkin A , Vite C , Steinberg SA
Published: September 2014

Five adult dogs presented for an acute onset of seizure activity. Magnetic resonance imaging revealed lesions in the olfactory bulbs, frontal lobes of the cerebrum, or both. A modified bilateral transfrontal sinus craniotomy was performed on each patient. The goal of removing the lesion was to relieve clinical signs and to provide tissue for histopathological diagnosis. In each instance, excision of the lesion was possible using this approach. No postoperative complications were observed. The modified bilateral transfrontal sinus craniotomy provides excellent access to the canine olfactory bulbs and frontal lobes.
Probable hypercalcemia of malignancy in a cat with bronchogenic adenocarcinoma
Authors: Anderson TE , Legendre AM , McEntee MM
Published: September 2014

An eight-year-old, neutered male, domestic shorthair cat was referred with a four-day history of acute vomiting. Hypercalcemia was identified on serum biochemical testing. Thoracic radiographs showed multiple pulmonary nodular densities. Postmortem and histopathological examination identified the nodules as bronchogenic adenocarcinoma with metastases to the tracheobronchial lymph nodes, diaphragm, and parietal pleura. To the authors' knowledge, this is the first reported case of hypercalcemia of malignancy associated with bronchogenic adenocarcinoma in a cat.
Caudal cervical intervertebral disk disease in the small dog: role of distraction and stabilization in ventral slot decompression
Authors: Fitch RB , Kerwin SC , Hosgood G
Published: September 2014

The clinical outcomes in 112 dogs weighing less than 35 pounds that were presented with cervical intervertebral disk protrusions were retrospectively evaluated. Although the second to third cervical (C2 to C3) intervertebral space was the most common site (27%) of disk protrusion, 57% of disk protrusions presented were caudal to the fourth cervical (C4) vertebra. Dogs with cranial intervertebral disk protrusions, including the C2 to C3 and C3 to C4 intervertebral disk spaces, responded favorably to ventral slot decompression. By comparison, caudal intervertebral disk protrusions (within the C4 to the seventh cervical [C7] intervertebral disk spaces) responded less favorably to ventral slot decompression, demonstrating significantly more severe clinical effects in motor function, comfort, recovery, and long-term outcome following surgery. Significant improvement in clinical results was seen in caudal disk protrusions when additional surgical distraction and stabilization were provided following ventral slot decompression.
Intrapericardial cyst causing cardiac tamponade in a cat
Authors: Less RD , Bright JM , Orton EC
Published: September 2014

A two-year-old cat with episodic dyspnea was diagnosed with an intrapericardial cyst via two-dimensional echocardiography. The cyst directly compressed the right ventricle, resulting in cardiac tamponade. Centesis of the cyst was performed to reduce tamponade prior to surgery. At surgery, a large, fluid-filled cystic structure was found within the pericardium. The cystic structure was continuous with a pedicle of liver that passed through a small peritoneopericardial diaphragmatic hernia. Surgical resolution was achieved by median sternotomy, midline pericardotomy, resection of the cyst, and diaphragmatic herniorrhaphy.
Left ventricular outflow tract to left atrial fistula associated with endocarditis in a dog
Authors: Smith AN , Finn-Bodner ST , Dillon AR
Published: September 2014

A one-year-old, intact male, 28-kg, mixed-breed dog developed neurological episodes consistent with emboli. An acquired III/VI holosystolic heart murmur was ausculted in the mitral area, and valvular endocarditis with pulmonic and aortic insufficiency were noted at echocardiographic examination. An abnormal communication (i.e., fistula) between the left ventricular outflow tract (LVOT) and the left atrium adjacent to the mitral valve annulus was noted with Doppler imaging and confirmed with angiography. Infective valvular endocarditis was confirmed based on two of three blood cultures being positive for Staphylococcus intermedius. In humans, a sequela to infective endocarditis of the aortic or mitral valve, or both, is rupture of the mitral-aortic intervalvular fibrosa, resulting in a communication between the LVOT and the left atrium. This is the first report of this sequela in the dog.
Seroconversion of puppies to canine parvovirus and canine distemper virus: a comparison of two combination vaccines
Authors: Coyne MJ
Published: September 2014

Sixty puppies were randomly assigned to receive one of two commercially available combination vaccines, and responses to the canine parvovirus and canine distemper virus components of the vaccines were determined by measuring serum antibody titers. The percentage of puppies that seroconverted to canine parvovirus was significantly higher and the mean time for seroconversion was significantly shorter for puppies that received one of the vaccines than for puppies that received the other vaccine. Percentages of puppies that seroconverted to canine distemper virus were not significantly different.
Primary hemangiosarcoma of the iliopsoas muscle eliciting a peripheral neuropathy
Authors: Tucker DW , Olsen D , Kraft SL , Andrews GA , Gray AP
Published: September 2014

An eight-year-old, male castrated bullmastiff presented to the Kansas State University Veterinary Medical Teaching Hospital with left hind-limb paralysis. A mass was identified in the left paralumbar soft tissue adjacent to the fourth (L4) to sixth (L6) lumbar vertebrae by magnetic resonance imaging. The iliopsoas muscle contained the mass which was identified as a hemangiosarcoma on histopathological examination. Hemangiosarcoma is rarely reported as a primary tumor arising from muscle vascular endothelium.
Luxation of the superficial digital flexor tendon in a cat
Authors: WTJr McNicholas , Wilkens BE , Barstad RD
Published: September 2014

Superficial digital flexor luxation has been described in dogs, horses, and cattle. To the authors' knowledge, it has not been reported in cats. In the case of this report, monofilament nonabsorbable suture material was used to repair a laterally luxating superficial digital flexor tendon in a cat. The repair was similar to that which has been described in dogs. Whereas many etiologies of superficial tendon luxation have been proposed in dogs, trauma was believed to have contributed to the tendon luxation in this cat.
Meningoencephalitis secondary to bacterial otitis media/interna in a dog
Authors: Spangler EA , Dewey CW
Published: September 2014

Central nervous system (CNS) complications of bacterial otitis media/interna are an infrequent occurrence in human patients and have rarely been reported in the veterinary literature. Early recognition of CNS involvement and the use of appropriate diagnostic tests to characterize the nature of the lesion(s) are crucial in determining the best course of treatment. In this paper, the authors describe a dog with bacterial meningoencephalitis secondary to otitis media/interna.
Mineralization of the supraspinatus tendon in dogs: a long-term follow-up
Authors: Laitinen OM , Flo GL
Published: September 2014

Mineralization of the supraspinatus tendon was diagnosed in 24 large-breed dogs as a probable cause for a chronic unilateral forelimb lameness. Owners of 12 dogs responded to a questionnaire survey evaluating the treatment that their dog had received which consisted of either surgical removal of the mineralization after failure of conservative treatment (operated group; n=9) or rest and nonsteroidal anti-inflammatory drugs (NSAIDs) (nonoperated group; n=3). In eight out of the 12 dogs, the mineralization was also present in the asymptomatic forelimb. Based on owner evaluation, the degree of lameness had decreased distinctly in both groups. Six dogs (four operated and two nonoperated) were reevaluated at Michigan State University Veterinary Teaching Hospital (MSU-VTH) and were without lameness except for one dog in the operated group. The mineralizations had reformed in all dogs in the operated group after a mean follow-up time of 5.1 years.
Successful treatment of intratracheal cuterebrosis in two cats
Authors: Dvorak LD , Bay JD , Crouch DT , Corwin RM
Published: September 2014

Two cases of feline intratracheal myiasis due to Cuterebra spp. larvae are reported. Both cats presented with inspiratory dyspnea and a nonproductive cough. One larva was successfully removed during thoracotomy, and the other was removed during bronchoscopy using forceps passed through a bronchoscope operating channel. Clinical signs were alleviated following removal of the larvae.
Phenol poisoning in three dogs
Authors: Gieger TL , Correa SS , Taboada J , Grooters AM , Johnson AJ
Published: September 2014

Three adult dogs were evaluated following oral administration of phenol by the owner. All three dogs experienced severe oral and gastric ulceration. Hematological abnormalities included neutropenia with the presence of toxic neutrophils, thrombocytopenia, and increased muscle enzymes. Endoscopic examination was performed, and biopsies yielded a diagnosis of gastric mucosal necrosis in two of the dogs. Following supportive care, the dogs recovered completely. Phenol is a caustic, highly poisonous derivative of coal tar. The dogs of this report were poisoned inadvertently by their owner who received misinformation concerning the use of this chemical via the Internet.
Extraskeletal osteosarcoma in the duodenum of a cat
Authors: Stimson EL , Cook WT , Smith MM , Forrester SD , Moon ML , Saunders GK
Published: September 2014

A three-year-old, male neutered domestic longhair cat was referred for evaluation of icterus, vomiting, and anorexia. Abdominal ultrasonography revealed a proximal duodenal mass obstructing the common bile duct. The mass was surgically resected, and a cholecystoduodenostomy was performed. The histopathological diagnosis was osteosarcoma. Thoracic radiographs showed no evidence of metastasis, and bone scintigraphy revealed no signs of a primary skeletal osteosarcoma. Four months after surgery, the cat had intermittent vomiting, marked weight loss, and died.
Intravascular lymphoma presenting as bilateral panophthalmitis and retinal detachment in a dog
Authors: Cullen CL , Caswell JL , Grahn BH
Published: September 2014

A seven-year-old, spayed female boxer was presented for sudden blindness and red eyes of one week's duration. Ophthalmic examination revealed bilateral uveitis with complete bullous retinal detachments. Initial diagnostic testing failed to reveal evidence of systemic disease. Cytopathology of subretinal aspirates confirmed the presence of macrophages with intracytoplasmic retinal pigment, epithelial and choroidal pigment, and monocytes. Tentative diagnoses were idiopathic uveitis and retinal detachment. The dog was treated with immunosuppressive doses of prednisone. The retinas reattached and vision returned. By two months, the dog became blind and systemically ill. Postmortem and histopathological examinations revealed intravascular lymphoma in multiple organs, including the eyes.
Chronic primary splenic torsion with peritoneal adhesions in a dog: case report and literature review
Authors: Weber NA
Published: September 2014

Primary splenic torsion in dogs is uncommon and can occur in acute or chronic form. The chronic form is difficult to diagnose because the clinical signs are vague and sometimes intermittent. A dog with a history of diaphragmatic hernia repair two years previously presented with chronic, vague clinical signs and an abdominal mass. The mass was revealed to be spleen on ultrasonography. On exploratory laparotomy, the dog was found to have a splenic torsion of approximately 180 degrees with mature, fibrous adhesions retaining the spleen in a torsed position. A splenectomy was performed, and the dog recovered uneventfully with complete resolution of prior clinical signs. Prognosis for dogs with splenic torsion is good, although complications are relatively common.
Combined doxorubicin and cyclophosphamide chemotherapy for nonresectable feline fibrosarcoma
Authors: Barber LG , Sorenmo KU , Cronin KL , Shofer FS
Published: September 2014

A retrospective evaluation was performed on 12 cats with nonresectable, histopathologically confirmed fibrosarcomas that were treated with doxorubicin and cyclophosphamide chemotherapy. All of the tumors were located in sites potentially used for vaccination. Six cats had a greater than 50% decrease in gross tumor burden. However, the responses were not durable, with a median response duration of 125 days. All cats developed progressive disease. When animals that received other treatments after doxorubicin-based chemotherapy were eliminated from the analysis, median survival time was significantly longer for cats that responded to chemotherapy compared with the median survival time for nonresponders (242 and 83 days, respectively). These findings may serve as a basis for further evaluating the role of chemotherapy in the treatment of vaccine-associated sarcomas.
The efficacy of topical prophylactic antiglaucoma therapy in primary closed angle glaucoma in dogs: a multicenter clinical trial
Authors: Miller PE , Schmidt GM , Vainisi SJ , Swanson JF , Herrmann MK
Published: September 2014

The ability of either 0.5% betaxolol (1 drop topically, bid; n=31) or a combination of 0.25% demecarium bromide and a topical corticosteroid (gentamicin/betamethasone) (DB/GB; 1 drop of each topically, sid; n=55) to prevent glaucoma in the fellow eye of dogs with unilateral, primary closed angle glaucoma (PCAG) was investigated in a multicenter, open-label, clinical trial. Untreated control dogs (n=20) developed glaucoma significantly sooner (median, eight mos; p less than 0.001) than dogs treated either with DB/GB (median, 31 mos) or betaxolol (median, 30.7 mos). Although DB/GB and betaxolol equally delayed or prevented the onset of glaucoma in the second eye, a less frequent dosing schedule for DB/GB suggests demecarium bromide in combination with a topical corticosteroid may be preferable to betaxolol in preventing PCAG in dogs.
Assessing the efficacy of perioperative carprofen administration in dogs undergoing surgical repair of a ruptured cranial cruciate ligament
Authors: Reese CJ , Trotter EJ , Short CE , Erb HN , Barlow LL
Published: September 2014

Twenty-one otherwise healthy dogs that presented for surgical repair of a ruptured cranial cruciate ligament were blindly and randomly given either carprofen (2.2 mg/kg body weight, orally) or a placebo beginning 12 hours preoperatively and continuing every 12 hours for a total of three doses. The patients were assessed for postoperative pain using a subjective pain score and given oxymorphone (0.1 mg/kg body weight, intramuscularly) every four hours if the pain score was 2 or greater. Blood samples were also collected to determine serum cortisol levels. There was a significant increase in serum cortisol levels in the immediate postoperative period in both the placebo group and the carprofen group (p less than 0.05). There was no significant difference in the percentage of increase in serum cortisol levels between the two groups. No correlation was evident between the serum cortisol levels and the corresponding pain scores in either group. This subjective method of assessing postoperative pain was not accurate and should not be relied upon for determination of postoperative analgesic administration. Perioperative oral administration of carprofen did not appear to be effective in controlling postoperative pain in these patients.
Hyperadrenocorticism and hyperprogesteronemia in a cat with an adrenocortical adenocarcinoma
Authors: JHJr Rossmeisl , Scott-Moncrieff JC , Siems J , Snyder PW , Wells A , Anothayanontha L , Oliver JW
Published: September 2014

A seven-year-old, neutered male domestic shorthair cat was evaluated for poorly regulated diabetes mellitus and increased skin fragility. Imaging studies revealed a right adrenal gland tumor, but cortisol testing did not support a diagnosis of hyperadrenocorticism. Serum concentrations of progesterone and testosterone were increased compared with a group of normal cats, and the clinical signs were attributed to hyperprogesteronemia. At necropsy, a diagnosis of adrenocortical adenocarcinoma was confirmed, and immunohistochemical staining confirmed the presence of progesterone within the tumor. Clinical signs of hyperadrenocorticism in cats may occur due to increased serum concentrations of hormones other than cortisol.
Feline osteosarcoma: 145 cases (1990-1995)
Authors: Heldmann E , Anderson MA , Wagner-Mann C
Published: September 2014

Feline osteosarcoma (OSA) is a rare tumor in cats. Ninety (62%) of feline OSAs detailed in this study arose from the skeleton, and 55 (38%) arose from extraskeletal sites. Fifty OSAs originated in the appendicular skeleton, and 40 OSAs originated in the axial skeleton. Extraskeletal OSA sites included subcutaneous sites (n=44), with an apparent prevalence for sites commonly used for vaccination. Other locations included ocular/orbital (n=4), oral (n=3), intestinal/omental (n=3), and mammary sites (n=1). Survival data was available for 74 cases. When considered as a group, cats with either appendicular (mean, 11.8 mos) or extraskeletal (mean, 12.67 mos) OSA survived longer than those with axial (mean, 6.07 mos) OSA. Regardless of the type of feline OSA, aggressive surgical excision with or without ancillary therapy appeared to be the most effective form of treatment.
Case examples demonstrating the clinical utility of obtaining both right and left lateral abdominal radiographs in small animals
Authors: Armbrust LJ , Biller DS , Hoskinson JJ
Published: September 2014

Seven case examples are presented which illustrate the utility of using both right to left and left to right laterolateral abdominal radiographs (left lateral and right lateral recumbent radiographs, respectively) when evaluating gastrointestinal disease. These cases demonstrate the benefits of obtaining both lateral abdominal radiographs in disease of the stomach, small intestine, and large intestine. A review of the literature concerning this technique is provided.
Compression radiography: an old technique revisited
Authors: Armbrust LJ , Biller DS , Hoskinson JJ
Published: September 2014

Five case examples are provided to illustrate the use of compression radiography in the dog and cat. Abdominal compression radiography provides for evaluation of the size, shape, location, and opacity of a specific area without the degree of superimposition encountered with survey radiographs. The following cases illustrate compression techniques of the intestinal tract, uterus, kidney, bladder, and spleen. A review of the technique as well as a discussion of the advantages and limitations are presented.
Retrospective evaluation of occlusion of patent ductus arteriosus with hemoclips in 20 dogs
Authors: Corti LB , Merkley D , Nelson OL , Ware WA
Published: September 2014

Twenty dogs with patent ductus arteriosus occluded with Hemoclips were evaluated with a mean follow-up time of 799.4 days (range, 83 to 3,580 days). Significant decreases were found between pre- and postsurgical means for vertebral heart size and for echocardiographic left atrial/aortic-root ratios and percent fractional shortening (%FS). Despite a good clinical outcome, six of 20 dogs had persistent cardiomyopathy of overload with diminished %FS (28% or less) at follow-up. One dog had residual ductal flow identified five days postoperatively. Subsequent evaluations in this case at 60, 144, 226, 344, and 560 days postoperatively demonstrated gradually diminishing ductal flow. The remaining 19 dogs did not recanalize.
Anatomy of the lumbosacral spinal cord in rabbits
Authors: Greenaway JB , Partlow GD , Gonsholt NL , Fisher KR
Published: September 2014

This study provides an accurate, anatomical description of the rabbit's lumbosacral spinal cord. Following humane euthanasia, 64 rabbits were radiographed and dissected. The number of thoracic (T) and lumbar (L) vertebrae was 12T/7L in 43.8%, 13T/6L in 32.8%, and 13T/7L in 23.4% in the 64 rabbits studied. The 13th ribs were rudimentary, asymmetric, or both in 15 animals. The spinal cord terminated within the second sacral vertebra (S2) in 79.3%, within the first sacral vertebra (S1) in 19.0%, and within the third sacral vertebra (S3) in 1.7% of the sample. Spinal nerve contributions to the femoral, obturator, sciatic, and pudendal nerves were determined. Formulas to predict the termination of the cord relative to the vertebral column were established. Age, weight, sex, and method of preparation did not show a significant correlation with the length of the spinal cord.
Canine Rocky Mountain Spotted fever: a retrospective study of 30 cases
Authors: Gasser AM , Birkenheuer AJ , Breitschwerdt EB
Published: September 2014

Rocky Mountain spotted fever (RMSF) was diagnosed in 30 dogs examined at North Carolina State University, Veterinary Teaching Hospital between 1984 and 1997. Historical, physical examination, and laboratory abnormalities were reviewed. Diagnostic criteria included a four-fold rise in antibody titer to Rickettsia rickettsii (R. rickettsii) (n=15) or a single R. rickettsii antibody titer of 1:1,024 or greater (n=15; when this initial titer was determined one week or more after the onset of clinical signs). Fifteen (50%) dogs were greater than seven years of age, and 13 (43%) dogs were between two and seven years of age. There was no sex predilection. Only five (17%) dogs had a history of known tick exposure. Presumably due to delayed diagnosis, dogs with antibody titers of 1:1,024 or greater at the time of presentation had a higher incidence of more severe neurological dysfunction (e.g., ataxia, hyperesthesia, vestibular disease, and seizures) and cutaneous lesions (e.g., hyperemia, edema, petechiae, ecchymoses, and necrosis). Laboratory findings included anemia, leukocytosis accompanied by toxic granulation of neutrophils, hypoalbuminemia, and coagulation abnormalities; signs were generally more severe in the 15 dogs with R. rickettsii antibody titers of 1:1,024 or greater at the time of presentation. Twelve (40%) dogs in this study were severely thrombocytopenic (less than 75 x10(3) platelets/microl; reference range, 200 to 450 x 10(3)/microl), without clinical evidence of fulminant disseminated intravascular coagulation. In this study, the survival rate following R. rickettsii infection was 100%.
Possible causal association of idiopathic inflammatory bowel disease with thrombocytopenia in the dog
Authors: Ridgway J , Jergens AE , Niyo Y
Published: September 2014

Extraintestinal manifestations of inflammatory bowel disease (IBD) are commonly observed in humans but are poorly documented in companion animals. Thrombocytopenia is an uncommon but well-documented extraintestinal hematological abnormality in humans; however, there are no previous reports of IBD and concurrent thrombocytopenia in the veterinary literature. Seven dogs having idiopathic IBD and concurrent thrombocytopenia were identified and evaluated retrospectively (this represents an incidence of 2.5% in the authors' IBD population). Obvious known causes for thrombocytopenia were eliminated by diagnostic testing as deemed appropriate by the clinician of record. Thrombocytopenia resolved with treatment for the IBD in some but not all patients. This is similar to reports in humans. Thrombocytopenia typically appears to be subclinical, and the severity does not correlate with the degree of intestinal inflammation defined histopathologically. However, quantitative platelet counts should be monitored during IBD therapy, as additional immunosuppression may be required to treat thrombocytopenia, despite resolution of gastrointestinal signs. It is speculated that thrombocytopenia may be causally associated with canine IBD, possibly secondary to immune stimulation from lumenal bacterial antigens, altered immunological regulation, or both.
Chronic idiopathic pulmonary fibrosis in five dogs
Authors: Lobetti RG , Milner R , Lane E
Published: September 2014

Five dogs presented with chronic and progressive pulmonary illness characterized by progressive dyspnea, exercise intolerance, and significant inspiratory crackles on auscultation. Radiographically, there was a widespread and diffuse interstitial lung pattern with varying degrees of bronchial involvement. Histopathological changes included thickened alveolar septa, interstitial fibrosis, and pneumocyte hyperplasia. Based on the clinical, radiographic, and histopathological changes, a diagnosis of idiopathic pulmonary fibrosis was made. Idiopathic pulmonary fibrosis is a chronic disease characterized by inflammation and fibrosis of the pulmonary interstitium and peripheral airspaces, which has been poorly characterized in the dog.
Serum alpha 1-acid glycoprotein concentration in cats with lymphoma
Authors: Correa SS , Mauldin GN , Mauldin GE , Mooney SC
Published: September 2014

Serum alpha 1-acid glycoprotein (AGP) concentrations were evaluated in nine cats with lymphoma. Twenty-five healthy cats were used as controls. Blood samples were obtained from cats with lymphoma prior to induction chemotherapy, one week following induction, at complete response, and at monthly intervals. The median pretreatment AGP concentration for the nine cats with lymphoma was significantly higher than the median AGP concentration for the 25 control cats. Remission serum AGP concentration was not significantly different from the pretreatment AGP concentration in the cats with lymphoma. Serum AGP concentrations provided no useful information regarding response or survival in cats with lymphoma.