bluuebunny/crossref_metadata_2025 huggingface dataset:
Osteogenesis Imperfecta: Search for Mutations in Patients from the Republic of Bashkortostan (Russia)
Authors: Nadyrshina Dina , Zaripova Aliya , Tyurin Anton , Minniakhmetov Ildar , Zakharova Ekaterina , Khusainova Rita
Published: January 2022

Osteogenesis imperfecta (OI) is an inherited disease of bone characterized by increased bone fragility. Here, we report the results of the molecular architecture of osteogenesis imperfecta research in patients from Bashkortostan Republic, Russia. In total, 16 mutations in COL1A1, 11 mutations in COL1A2, and 1 mutation in P3H1 and IFIMT5 genes were found in isolated states; 11 of them were not previously reported in literature. We found mutations in CLCN7, ALOX12B, PLEKHM1, ERCC4, ARSB, PTH1R, and TGFB1 that were not associated with OI pathogenesis in patients with increased bone fragility. Additionally, we found combined mutations (c.2869C>T, p. Gln957* in COL1A1 and c.1197+5G>A in COL1A2; c.579delT, p. Gly194fs in COL1A1 and c.1197+5G>A in COL1A2; c.2971G>C, p. Gly991Arg in COL1A2 and c.212G>C, p.Ser71Thr in FGF23; c.-14C>T in IFITM5 and c.1903C>T, p. Arg635* in LAMB3) in 4 patients with typical OI clinic phenotypes.
Inclusions of Amorphous and Crystalline SiO2 in Minerals from Itrongay (Madagascar) and Other Evidence for the Natural Occurrence of Hydrosilicate Fluids
Authors: Popov Daniil V. , Spikings Richard A. , Razakamanana Théodore
Published: January 2022

Experimental studies increasingly often report low-temperature (200–800 °C) and low-pressure (0.05–3 kbar) hydrosilicate fluids with >40 wt.% of SiO2 and >10 wt.% of H2O. Compositionally similar fluids were long suggested to potentially exist in natural systems such as pegmatites and hydrothermal veins. However, they are rarely invoked in recent petrogenetic models, perhaps because of the scarcity of direct evidence for their natural occurrence. Here we review such evidence from previous works and add to this by documenting inclusions of hydrosilicate fluids in quartz and feldspar from Itrongay. The latter comprise opal-A, opal-CT, moganite and quartz inclusions that frequently contain H2O and have negative crystal shapes. They coexist with inclusions of CO2- and H2O-rich fluids and complex polycrystalline inclusions containing chlorides, sulphates, carbonates, arsenates, oxides, hydroxides and silicates, which we interpret as remnants of saline liquids. Collectively, previous studies and our new results indicate that hydrosilicate fluids may be common in the Earth’s crust, although their tendency to transform into quartz upon cooling and exhumation renders them difficult to recognise. These data warrant more comprehensive research into the nature of such hydrosilicate fluids and their distribution across a wide range of pressure and temperature conditions and geological systems.
Effects of Artificial Sweat Formulation and Extraction Temperature on Estimation of the Dermal Bioaccessibility of Potentially Toxic Elements in a Contaminated Soil from an E-Waste Recycling Site
Authors: Anselm Oluwaseun H. , Davidson Christine M. , Oyeyiola Aderonke O. , Oluseyi Temilola O.
Published: January 2022

Informal recycling of electronic waste leads to soil contamination that can impact human health. To accurately assess exposure to potentially toxic elements (PTE) in soil it is necessary to consider their bioavailability through ingestion, inhalation and dermal contact. However, bioaccessibility tests that estimate dermal absorption following adhesion of contaminated soil particles to skin are not well established. In this study the concentrations of As, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn were estimated in the <45 µm particle size fraction of a bulk composite soil from an e-waste recycling site using five different artificial sweat formulations. Extractions were performed at temperatures ranging from 17 to 47 °C to investigate the effect of ambient temperature on bioaccessibility. Results obtained using the different artificial sweats were not consistent with one another. In particular, the NIHS 96-10 formulation solubilized larger amounts of analytes (ranging from 6.3 times the next most effective extractant for Cu to 1700 times the next most effective for Pb). There was a general increase in release of PTE with increasing temperature, except for As. Although trends varied between analytes and formulations, this highlights the need to consider ambient temperature when estimating dermal bioaccessibility of PTE in soil.
Non-Destructive In Situ Investigation of the Study of a Medieval Copper Alloy Door in Canosa di Puglia (Southern Italy)
Authors: Buccolieri Giovanni , Castellano Alfredo , Iacobelli Vito Nicola , Carbone Giorgio Giuseppe , Serra Antonio , Calcagnile Lucio , Buccolieri Alessandro
Published: January 2022

This paper reports the analyses carried out on the medieval copper alloy door (1111–1118 AD) of the mausoleum of Boemondo d’Altavilla in Canosa di Puglia (Southern Italy). The studied door is the smallest medieval bronze door extant in Italy and, unlike the other Byzantine doors, was most probably made in Canosa di Puglia and not in Constantinople. Analyses were performed to assess the chemical composition of the alloy patinas using a portable energy dispersive X-ray fluorescence (ED-XRF) instrument designed at the University of Salento. The experimental results suggested that the two door leaves have the same chemical composition, even if they appear different in both style and size. Furthermore, the alloy used for the door is different from the other previously-analyzed Byzantine bronze doors. The obtained results can be used in the future to compare the chemical composition of other Byzantine doors in order to better understand the manufacture of these precious artifacts.
Radon Hazard in Central Italy: Comparison among Areas with Different Geogenic Radon Potential
Authors: Giustini Francesca , Ruggiero Livio , Sciarra Alessandra , Beaubien Stan Eugene , Graziani Stefano , Galli Gianfranco , Pizzino Luca , Tartarello Maria Chiara , Lucchetti Carlo , Sirianni Pietro , Tuccimei Paola , Voltaggio Mario , Bigi Sabina , Ciotoli Giancarlo
Published: January 2022

Radon (222Rn) is a natural radioactive gas formed in rocks and soil by the decay of its parent nuclide (238-Uranium). The rate at which radon migrates to the surface, be it along faults or directly emanated from shallow soil, represents the Geogenic Radon Potential (GRP) of an area. Considering that the GRP is often linked to indoor radon risk levels, we have conducted multi-disciplinary research to: (i) define local GRPs and investigate their relationship with associated indoor Rn levels; (ii) evaluate inhaled radiation dosages and the associated risk to the inhabitants; and (iii) define radon priority areas (RPAs) as required by the Directive 2013/59/Euratom. In the framework of the EU-funded LIFE-Respire project, a large amount of data (radionuclide content, soil gas samples, terrestrial gamma, indoor radon) was collected from three municipalities located in different volcanic districts of the Lazio region (central Italy) that are characterised by low to high GRP. Results highlight the positive correlation between the radionuclide content of the outcropping rocks, the soil Rn concentrations and the presence of high indoor Rn values in areas with medium to high GRP. Data confirm that the Cimini–Vicani area has inhalation dosages that are higher than the reference value of 10 mSv/y.
Relationship between Isokinetic Knee Strength and Speed, Agility, and Explosive Power in Elite Soccer Players
Authors: Kabacinski Jaroslaw , Szozda Piotr M. , Mackala Krzysztof , Murawa Michal , Rzepnicka Agata , Szewczyk Piotr , Dworak Lechoslaw B.
Published: January 2022

The aim of this study was to determine the relationship between the isokinetic characteristics of knee extensors and flexors with selected motor abilities: Speed, agility, and explosive power of lower extremities of professional football players in the preparation period of a yearly training cycle. Twenty-one players (age: 24.5 ± 3.9 years; body mass: 76.7 ± 4.7 kg and body height: 183.5 ± 5.5 cm) playing in the highest Polish soccer league participated in the study. The isokinetic concentric torque of the knee extensors and flexors was measured at 300°/s, 180°/s, and 60°/s velocities. Sprint performance was assessed in the 30 m sprint test (standing start). The forward, lateral, and backward movements were assessed using the T-Test of agility. Explosive power was quantified by performing the squat jump (SJ) and countermovement (CMJ), using the force platform. Due to sport-specific demands of soccer activities measured in this experiment, the relationships between peak torque (PT) and the 30 m sprint, T-Test of agility, and power of vertical jumps (SJ and CMJ) were low or medium at speeds of 60°/s and 300°/s. One of the main reasons for the lack of high dependence of the above-mentioned factors are that the measurements were performed during the initial training period where the level of individual abilities is at a low level. Additionally, this experiment may also indicate that the measurement of isokinetic knee flexion and extension peak is effective when performed at the correct angular velocity in relation to the evaluation of the intended motion structure.
Enabling the Circular Economy Transition in Organizations: A Moderated Mediation Model
Authors: Bîrgovan Andreea Loredana , Vatca Sorin Daniel , Bacali Laura , Szilagyi Andrea , Lakatos Elena Simina , Cioca Lucian Ionel , Ciobanu George
Published: January 2022

The notion of Corporate Environmental Responsibility has been extensively researched in the literature so far, but less is known about how this concept fits into the circular economy paradigm. We performed a moderated mediation analysis in order to identify the mechanism that links corporate environmental responsibility with readiness for change towards a circular economy business model. The findings from 311 respondents show that there is a positive association between corporate environmental responsibility and the readiness for change to a circular model, mediated by perceived circular economy drivers. In addition, perceived circular economy barriers hinder this positive relationship, acting as a buffer. These findings can further contribute to the elaboration of a conceptual framework for embedding circular economy in the corporate social responsibility strategies of organizations.
Single, Dual, and Triple Use of Cigarettes, e-Cigarettes, and Snus among Adolescents in the Nordic Countries
Authors: Raitasalo Kirsimarja , Bye Elin K. , Pisinger Charlotta , Scheffels Janne , Tokle Rikke , Kinnunen Jaana M. , Ollila Hanna , Rimpelä Arja
Published: January 2022

New tobacco and nicotine products have emerged on the market in recent years. Most research has concerned only one product at a time, usually e-cigarettes, while little is known about the multiple use of tobacco and nicotine products among adolescents. We examined single, dual, and triple use of cigarettes, e-cigarettes, and snus among Nordic adolescents, using data of 15–16-year-olds (n = 16,125) from the European School Survey Project on Alcohol and other Drugs (ESPAD) collected in 2015 and 2019 from Denmark, Finland, Iceland, Norway, Sweden, and the Faroe Islands. Country-specific lifetime use of any of these products ranged between 40% and 50%, and current use between 17% and 31%. Cigarettes were the most common product in all countries except for Iceland, where e-cigarettes were remarkably more common. The proportion of dual and triple users was unexpectedly high among both experimental (24%–49%) and current users (31–42%). Triple use was less common than dual use. The users’ patterns varied somewhat between the countries, and Iceland differed substantially from the other countries, with a high proportion of single e-cigarette users. More knowledge on the patterns of multiple use of tobacco and nicotine products and on the potential risk and protective factors is needed for targeted intervention and prevention efforts.
Increasing Healthy Food Access for Low-Income Communities: Protocol of the Healthy Community Stores Case Study Project
Authors: Gittelsohn Joel , Kasprzak Christina M. , Hill Alex B. , Sundermeir Samantha M. , Laska Melissa N. , Dombrowski Rachael D. , DeAngelo Julia , Odoms-Young Angela , Leone Lucia A.
Published: January 2022

Improving healthy food access in low-income communities continues to be a public health challenge. One strategy for improving healthy food access has been to introduce community food stores, with the mission of increasing healthy food access; however, no study has explored the experiences of different initiatives and models in opening and sustaining healthy food stores. This study used a case study approach to understand the experiences of healthy food stores in low-income communities. The purpose of this paper is to describe the methodology used and protocol followed. A case study approach was used to describe seven healthy food stores across urban settings in the U.S. Each site individually coded their cases, and meetings were held to discuss emerging and cross-cutting themes. A cross-case analysis approach was used to produce a series of papers detailing the results of each theme. Most case studies were on for-profit, full-service grocery stores, with store sizes ranging from 900 to 65,000 square feet. Healthy Food Availability scores across sites ranged from 11.6 (low) to 26.5 (high). The papers resulting from this study will detail the key findings of the case studies and will focus on the challenges, strategies, and experiences of retail food stores attempting to improve healthy food access for disadvantaged communities. The work presented in this special issue will help to advance research in the area of community food stores, and the recommendations can be used by aspiring, new, and current community food store owners.
Empathy, Burnout, and Attitudes towards Mental Illness among Spanish Mental Health Nurses
Authors: Román-Sánchez Daniel , Paramio-Cuevas Juan Carlos , Paloma-Castro Olga , Palazón-Fernández José Luis , Lepiani-Díaz Isabel , de la Fuente Rodríguez José Manuel , López-Millán María Reyes
Published: January 2022

Mental health nurses, together with psychiatrists, are the healthcare professionals who display the highest levels of empathy and the best attitudes towards patients with mental disorders. However, burnout is a common problem among these professionals. The aim of our study is to describe the association between empathy, burnout, and attitudes towards patients with mental disorders among mental health nurses in Spain. A descriptive cross-sectional design was used involving a sample of 750 specialist nurses working in mental health facilities in Spain. An intentional, non-probability, non-discriminative, exponential snowball sampling method was used. The Jefferson Scale of Empathy, the Maslach Burnout Inventory, and the Community Attitudes towards Mental Illness Inventory were used to measure the study variables. A positive correlation was observed between empathy and all the study variables, with the exception of the personal accomplishment dimension of burnout and the social restrictiveness and authoritarianism dimensions of attitudes towards mental illness, where a negative relation was observed. Our findings suggest that empathy is associated with an increase in positive attitudes towards patients with mental disorders, decreasing associated stigma, but did not act as a protective factor against burnout in the study sample.
Job Insecurity and Employees’ Taking Charge Behaviors: Testing a Moderated Mediation Model
Authors: Sun Fang , Zheng Anqi , Lan Junbang
Published: January 2022

Given the rapid changes in current technologies, business models, and work environments, organizations and managers increasingly rely on their employees’ proactive behaviors, such as taking charge, to gain competitive advantages. Taking charge involves a range of risky and future-oriented behaviors, and it requires employees to work hard to achieve them in the future. For employees with high job-insecurity, their job continuity in the future is threatened. Thus, they may not be willing to take risks to do additional work that is “future-oriented”. To our knowledge, the effect of job insecurity on employees’ taking charge has rarely been studied. As a result, the purpose of our study is to investigate whether, how, and when job insecurity will influence taking charge. Drawing on the conservation of resources theory and proactive motivation model, we develop a theoretical model. Moreover, we employed a multi-wave and multi-source survey to test our predictions. Based on the data from 194 full-time employees paired with their direct supervisors, the results provided consistent support for the proposed hypotheses. Specifically, the results indicate that job insecurity prohibits employees’ taking charge behaviors through deteriorating their work engagement. Furthermore, employees’ perception of interactional justice moderates the negative influence of job insecurity on their work engagement and, consequently, their taking charge behaviors. Theoretical and practical implications are discussed.
Substance Use, Hospitalizations, and Co-Occurring Disorders among Patients Transferred from a Needle Exchange Program to Opioid Maintenance Treatment
Authors: Bråbäck Martin , Brantefors Anna , Franck Johan , Brådvik Louise , Isendahl Pernilla , Nilsson Suzan , Troberg Katja , Håkansson Anders
Published: January 2022

Opioid use disorders (OUD) is a relapsing condition with high mortality. Opioid maintenance treatment (OMT) reduces heroin use, and overall morbidity and mortality. The prevalence of psychiatric and substance use disorders, potential baseline predictors for psychiatric hospitalization, and psychiatric diagnoses at follow-up were investigated and may give hints about possible preventative strategies. The medical records for 71 patients were reviewed 36 months following referral to OMT from a needle exchange program (NEP). Their psychiatric diagnoses and hospitalizations were identified. Their baseline characteristics were assessed for potential differences between hospitalized versus non-hospitalized patients and between patients with and without psychiatric diagnoses in a longitudinal observational study without controls. A regression analysis was performed to identify predictors for hospitalization when controlling for OMT status. Sixty-five percent of the patients were hospitalized at least once with a psychiatric diagnosis. Substance-related reasons were prevalent, and detoxification occurred among 59% of patients, with sedative- hypnotics (benzodiazepines, zopiclone, zolpidem, and pregabalin) being the substance used by 52% of patients. Baseline use of these drugs and/or buprenorphine predicted for hospitalization when controlling for OMT status. During the follow-up period, 72% of patients met the criteria for a psychiatric diagnosis other than OUD. The prevalence of non-substance use disorders overlapping with SUD was 41%, and that overlapping with anxiety disorder was 27% of all participants. Increased attention to psychiatric co-occurring disorders in the treatment of OUD is required and the importance of addressing sedative-hypnotics use when initiating OMT is highlighted.
Tokophobia and Anxiety in Pregnant Women during the SARS-CoV-2 Pandemic in Poland—A Prospective Cross-Sectional Study
Authors: Makara-Studzińska Marta , Zaręba Kornelia , Kawa Natalia , Matuszyk Dorota
Published: January 2022

SARS-CoV-2 coronavirus emerged in the world at the end of 2019. The introduction of a number of restrictions had a significant effect on numerous aspects of human life with particular influence being exerted on pregnant women and their sense of security. The study aimed to assess the level of anxiety and its main determinants in women in the third trimester of pregnancy during the coronavirus pandemic. The study technique included the present purposely designed questionnaire, Labor Anxiety Questionnaire (KLPII), and the State-Trait Anxiety Inventory (STAI). The study was conducted in a group of 315 women in the third trimester of pregnancy. A total of 258 women (81.9%) completed the questionnaire in May 2020, and 57 of them (18.1%) completed it in October 2020. The overall analysis of the Labor Anxiety Questionnaire and the STAI inventory revealed a high level of anxiety, particularly situational anxiety, in pregnant women during the SARS-CoV-2 pandemic. The age and financial status of the women were the factors which contributed to the intensification of tokophobia. Women interviewed in October 2020 were characterized by higher tokophobia levels compared to the respondents included in May 2020. It seems justified to in-crease the vigilance in the diagnostics of possible mental disorders in the perinatal period during pandemic.
Access to COVID-19 Vaccination during the Pandemic in the Informal Settlements of Rome
Authors: Bentivegna Enrico , Di Meo Silvia , Carriero Anita , Capriotti Nadia , Barbieri Alberto , Martelletti Paolo
Published: January 2022

With the advent of vaccines, the world has a chance to see a real end to the COVID-19 pandemic. To make this possible, however, it is necessary that all groups of people are considered. Contexts of informal settlements and populations such as the homeless and migrants are often forgotten by vaccination campaigns. In this study, carried out as a result of a collaboration with MEDU, a non-profit association aimed at bringing healthcare to vulnerable populations, we provide important data related to the vaccination campaign carried out in the informal settlements of Rome. The objectives of this work are to (1) evaluate vaccination coverage in these contexts, (2) assess the gap with the vaccination coverage of the Italian population and try to hypothesize the causes, and (3) provide recommendations for how humanitarian associations can respond to reduce this gap. We observed important differences in vaccination coverage depending on the type of settlement. The percentage of vaccinated people in these contexts at the beginning of October range between 14.4% and 55.5%, underlining an important gap with the vaccination rate of Italy’s population, which is close to 80%. The data also show that particular attention must be paid to the transiting and irregular people as they are more at risk for a lack of access to vaccination. With this study, in which we provide recommendations that integrate MEDU’s fieldwork experience with the advice of the Framework report, we hope we can help those who work in similar contexts, to carry out a fair and effective vaccination campaign.
Effects of Plant Communities on Human Physiological Recovery and Emotional Reactions: A Comparative Onsite Survey and Photo Elicitation Study
Authors: Duan Yifan , Li Shuhua
Published: January 2022

We investigated the effects on humans, in terms of skin conductance levels (SCLs) and positive and negative affect schedule (PANAS) scores, of plant communities that differed in their vegetation structure (single-layer woodland, tree-shrub-grass composite woodland, tree-grass composite woodland, and single-layer grassland) through two perceptual methods: onsite surveying and photo elicitation. The results showed that (1) the choice of perception method significantly impacted the PANAS scores of the participants but had no influence on the SCL and (2) viewing a single-layer grassland reduced the SCL (representing the physiological stress level) and improved the positive affect score. The recovery effects for the four vegetation communities were ranked in the order of single-layer grassland > tree-shrub-grass composite woodland > single-layer woodland > tree-grass composite woodland. (3) Gender and professional background significantly impacted the plant community perception methods and landscape experience, and negative affect scores were lower for male participants than for female participants. Participants without backgrounds in landscape design exhibited higher positive affect scores under photo elicitation. Based on the conclusions drawn above, the onsite survey is preferable between the two perception methods. It is recommended that in future landscape designs, combinations of plant community types should be reasonably matched through onsite perception. These research results can provide a scientific basis for the future design of landscapes based on perception experience.
Monitoring Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) Levels in Mixed-Use Residential-Commercial Buildings in Shiraz, Iran: Assessing the Carcinogenicity and Non-Carcinogenicity Risk of Their Inhabitants
Authors: Baberi Zahra , Azhdarpoor Abooalfazl , Hoseini Mohammad , Baghapour Mohammadali , Derakhshan Zahra , Giannakis Stefanos
Published: January 2022

The aim of this study is to investigate the concentration of Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) compounds in the indoor air of residential-commercial complexes and to compare it with other residential buildings (control) as well as to assess the carcinogenicity and non-carcinogenicity risk of these pollutants. BTEX concentration was investigated in the indoor air of 30 ground floor restaurants, 30 upper residential units of the complexes, 20 adjacent residential units (control), and their corridors. The mean BTEX concentration measured in the upper residential units was reported higher than in the control residential units, though they were not significantly different. The lifetime cancer risk (LTCR) value calculated for benzene in the upper residential units was lower than 10−4 and higher than 10−6 across all ages, indicating a carcinogenicity risk. Furthermore, the mean hazard quotient (HQ) for all compounds was obtained lower than 1, suggesting no concern about the non-carcinogenicity risk of these compounds in the studied region. Nevertheless, considering the sources of benzene production in the indoor air as well as the carcinogenicity of these pollutants and the risk they pose in human health, application towards the reduction of the sources and concentration of benzene in the indoor air are necessary.
Air Quality of Work, Residential, and Traffic Areas during the COVID-19 Lockdown with Insights to Improve Air Quality
Authors: Alharbi Badr H. , Alhazmi Hatem A. , Aldhafeeri Zaid M.
Published: January 2022

This study investigated the concentrations of air pollutants (NO, NO2, NOx, SO2, CO, O3, PM10, and PM2.5) at three sites with different traffic loads (work, residential, and traffic sites) before, during, and after the COVID-19 lockdown. The main objective of this study was to evaluate the effects and associated potential pollution control implications of the lockdown on the quality of ambient air at three selected sites in the urban area of Riyadh City. The average concentrations of NO, NO2, NOx, and CO decreased during the lockdown period by 73%, 44%, 53%, and 32% at the work site; 222%, 85%, 100%, and 60% at the residential site; and 133%, 60%, 101%, and 103% at the traffic site relative to the pre-lockdown period, respectively. The average concentration of O3 increased by 6% at the work site, whereas the concentration of SO2 increased by 27% at the residential site and decreased by 6.5% at the work site. The changes in PM10 and PM2.5 varied and did not exhibit a clear pattern. The air quality index (AQI) results indicated that the contribution to “undesired” air quality by O3 was 35.29% of the lockdown period at the work site while contributions to undesired air quality by PM10 and PM2.5 were 75.6% and 100% at the work site, 94.5% and 100% at the residential site, and 96.7% and 100% at the traffic site, respectively. The findings of this study are useful for devising effective urban pollution abatement policies. Applying control measures comparable to the lockdown measures over one week will result in a decrease of approximately 19% and 15% in CO mean concentration and 25% and 18% in NO2 mean concentration at residential and traffic sites, respectively.
Correlations between Psychiatric Symptoms and Quality of Life in Patients with Psychological Disorders: Hospital-Based Retrospective Study
Authors: Su Pi-Yu , Kuo Shu-Fen , Chung Min-Huey
Published: January 2022

Little research has been conducted on the relationship between the five-item Brief Symptom Rating Scale (BSRS-5) and quality of life in patients with mood disorders. The purpose of this study was to investigate potential effects of psychological symptoms on quality of life in patients with psychological disorders. We recruited 124 patients with psychological disorders from a psychological teaching hospital in northern Taiwan. Data were obtained from medical records of all patients with a diagnosis of mood or adjustment disorder. We assessed psychological symptoms on the BSRS-5 and examined quality of life by using the Taiwanese version of the abbreviated World Health Organization Quality of Life Questionnaire (WHOQOL-BREF). We performed hierarchical linear regression analysis to explore the relationship between psychological symptoms and quality of life. The analysis revealed a significant correlation between the items on the BSRS-5 and WHOQOL and their correlations with the total scores on these assessments (p < 0.01 and p < 0.05). Our findings indicated that scores on the BSRS-5 can predict scores on quality of life. This suggests that psychometrically measured psychological symptoms constitute critical determinants of quality of life.
Bioaccessibility of Polycyclic Aromatic Hydrocarbons (PAHs) in Grilled Meat: The Effects of Meat Doneness and Fat Content
Authors: Hamidi Elliyana Nadia , Hajeb Parvaneh , Selamat Jinap , Lee Soo Yee , Abdull Razis Ahmad Faizal
Published: January 2022

Exposure to polycyclic aromatic hydrocarbons (PAHs) through diet is gaining concern due to the risk it poses to human health. This study evaluated the bioaccessibility of PAHs contained in charcoal-grilled beef and chicken in different segments of the gastrointestinal tract (GIT) with regard to the degree of doneness and fat content of the meats. The levels of 15 PAHs in the grilled meat samples and bioaccessible fractions were determined using high-performance liquid chromatography (HPLC) equipped with PAH column, and UV and fluorescence detectors. Total PAHs were found in beef (30.73 ng/g) and chicken (70.93 ng/g) before its digestion, and different PAHs’ bioaccessibility were observed in the different segments of GIT, with the highest in the stomach followed by the small intestine, despite the relatively higher bioaccessibility of individual PAHs in grilled beef as compared to those in grilled chicken. Additionally, the PAHs’ bioaccessibility increased with the increase in the degree of doneness. Positive linear correlation was observed for the PAHs’ bioaccessibility and the fat contents of grilled meat. Overall, this study highlights the influence of meat doneness (cooking time) and fat contents on the bioaccessibility and bioaccumulation of PAHs.
Modulation of Sleep Architecture by Whole-Body Static Magnetic Exposure: A Study Based on EEG-Based Automatic Sleep Staging
Authors: Yang Lei , Jiang Haoyu , Ding Xiaotong , Liao Zhongcai , Wei Min , Li Juan , Wu Tongning , Li Congsheng , Fang Yanwen
Published: January 2022

A steady increase in sleep problems has been observed along with the development of society. Overnight exposure to a static magnetic field has been found to improve sleep quality; however, such studies were mainly based on subjective evaluation. Thus, the presented data cannot be used to infer sleep architecture in detail. In this study, the subjects slept on a magneto-static mattress for four nights, and self-reported scales and electroencephalogram (EEG) were used to determine the effect of static magnetic field exposure (SMFE) on sleep. Machine learning operators, i.e., decision tree and supporting vector machine, were trained and optimized with the open access sleep EEG dataset to automatically discriminate the individual sleep stages, determined experimentally. SMEF was found to decrease light sleep duration (N2%) by 3.51%, and sleep onset latency (SOL) by 15.83%, while it increased deep sleep duration (N3%) by 8.43%, compared with the sham SMFE group. Further, the overall sleep efficiency (SE) was also enhanced by SMFE. It is the first study, to the best of our knowledge, where the change in sleep architecture was explored by SMFE. Our findings will be useful in developing a non-invasive sleep-facilitating instrument.
Analysis of the Water Demand-Supply Gap and Scarcity Index in Lower Amu Darya River Basin, Central Asia
Authors: Wang Zheng , Huang Yue , Liu Tie , Zan Chanjuan , Ling Yunan , Guo Chenyu
Published: January 2022

Lower reaches of the Amu Darya River Basin (LADB) is one of the typical regions which is facing the problem of water shortage in Central Asia. During the past decades, water resources demand far exceeds that supplied by the mainstream of the Amu Darya River, and has resulted in a continuous decrease in the amount of water flowing into the Aral Sea. Clarifying the dynamic relationship between the water supply and demand is important for the optimal allocation and sustainable management of regional water resources. In this study, the relationship and its variations between the water supply and demand in the LADB from the 1970s to 2010s were analyzed by detailed calculation of multi-users water demand and multi-sources water supply, and the water scarcity indices were used for evaluating the status of water resources utilization. The results indicated that (1) during the past 50 years, the average total water supply (TWS) was 271.88 × 108 m3/y, and the average total water demand (TWD) was 467.85 × 108 m3/y; both the volume of water supply and demand was decreased in the LADB, with rates of −1.87 × 108 m3/y and −15.59 × 108 m3/y. (2) percentages of the rainfall in TWS were increased due to the decrease of inflow from the Amu Darya River; percentage of agriculture water demand was increased obviously, from 11.04% in the 1970s to 44.34% in 2010s, and the water demand from ecological sector reduced because of the Aral Sea shrinking. (3) the supply and demand of water resources of the LADB were generally in an unbalanced state, and water demand exceeded water supply except in the 2010s; the water scarcity index decreased from 2.69 to 0.94, indicating the status changed from awful to serious water scarcity. A vulnerable balanced state has been reached in the region, and that water shortages remain serious in the future, which requires special attention to the decision-makers of the authority.
Effectiveness of a Mindfulness-Based Group Intervention for Chinese University Students with Sleep Problems
Authors: Fu Lin , Wei Shuang , Cheng Jin , Wang Xueqi , Zhou Yueyue , Li Yi , Zheng Hao
Published: January 2022

The increasing prevalence of sleep disorders among university students should be taken seriously. Group counseling involving a mindfulness-based strategy may help prevent students from developing insomnia and subsequent mental health disorders. This study aimed to evaluate the ameliorating effects of a mindfulness-based group intervention on sleep problems and emotional symptoms in university students in China. Twenty-one university students (16 females, 22.71 ± 4.28 years) who were not on medication were recruited and assigned to the intervention group based on the criterion of high levels of sleep problems. Additionally, twenty-four university students (19 females, 24.50 ± 0.93 years) were included as a nonrandomized control group. Individuals in the intervention group participated in a two-hour group intervention once a week for eight sessions. All participants completed self-reported questionnaire baseline tests, postintervention tests, and one-month follow-ups on mindfulness, sleep quality, anxiety and depressive symptoms. Repeated-measures ANOVA was performed. The results revealed significant intervention effects, with significant differences observed between the two groups in mindfulness and sleep quality. However, there was no significant effect of the intervention on anxiety and depressive symptoms. This study contributes to a better understanding of the effectiveness of mindfulness-based intervention in addressing sleep problems in university students.
Spatial Evolution of Coastal Tourist City Using the Dyna-CLUE Model in Koh Chang of Thailand during 1990–2050
Authors: Waiyasusri Katawut , Chotpantarat Srilert
Published: January 2022

Spatial evolution can be traced by land-use change (LUC), which is a frontier issue in the field of geography. Using the limited areas of Koh Chang in Thailand as the research case, this study analyzed the simulation of its spatial evolution from a multi-scenario perspective on the basis of the 1900–2020 thematic mapper/operational land imager (TM/OLI) remote sensing data obtained through the transfer matrix model, and modified LUC and the dynamic land-use change model (Dyna-CLUE). Over the past 30 years, the expansion of recreation areas and urban and built-up land has been very high (2944.44% and 486.99%, respectively) along the western coast of Koh Chang, which replaced the original mangrove forests, orchards, and communities. Logistic regression analysis of important variables affecting LUC revealed that population density variables and coastal plain topography significantly affected LUC, which showed strong β coefficients prominently in the context of a coastal tourist city. The results of the LUC and logistic regression analyses were used to predict future LUCs in the Dyna-CLUE model to simulate 2050 land-use in three scenarios: (1) natural evolution scenario, where a large patch expansion of agricultural land extends along the edge of the entire forest boundary around the island, particularly the southwestern areas of the island that should be monitored; (2) reserved area protection scenario, where the boundary of the conservation area is incorporated into the model, enabling forest preservation in conjunction with tourism development; and (3) recreation area growth scenario, where the southern area is the most susceptible to change at the new road crossing between Khlong Kloi village to Salak Phet village, and where land-use of the recreation area type is expanding. The model-projected LUC maps provide insights into possible changes under multiple pathways, which could help local communities, government agencies, and stakeholders jointly allocate resource planning in a systematic way, so that the development of various infrastructures to realize the potential impact on the environment is a sustainable coastal tourist city development.
The Effect of Tau and Taxol on Polymerization of MCF7 Microtubules In Vitro
Authors: Feizabadi Mitra Shojania , Castillon Venise Jan
Published: January 2022

Overexpression of Tau protein in breast cancer cells is identified as an indicator for potential resistance to taxane-based therapy. As reported findings have been obtained mostly from clinical studies, the undetermined underlying mechanism of such drug resistance needs to be thoroughly explored through comprehensive in vitro evaluations. Tau and Taxol bind to the beta tubulin site in microtubules’ structure. This is of particular interest in breast cancer, as microtubules of these cancer cells are structurally distinct from some other microtubules, such as neuronal microtubules, due to their unique beta tubulin isotype distribution. The observed changes in the in vitro polymerization of breast cancer microtubules, and the different function of some molecular motors along them, leave open the possibility that the drug resistance mechanism can potentially be associated with different responses of these microtubules to Tau and Taxol. We carried out a series of parallel experiments to allow comparison of the in vitro dual effect of Tau and Taxol on the polymerization of MCF7 microtubules. We observed a concentration-dependent demotion-like alteration in the self-polymerization kinetics of Tau-induced MCF7 microtubules. In contrast, microtubules polymerized under the simultaneous effects of Tau and Taxol showed promoted assembly as compared with those observed in Tau-induced microtubules. The analysis of our data obtained from the length of MCF7 microtubules polymerized under the interaction with Tau and Taxol in vitro suggests that the phenomenon known as drug resistance in microtubule-targeted drugs such as Taxol may not be directly linked to the different responses of microtubules to the drug. The effect of the drug may be mitigated due to the simultaneous interactions with other microtubule-associated proteins such as Tau protein. The observed regulatory effect of Tau and Taxol on the polymerization of breast cancer microtubules in vitro points to additional evidence for the possible role of tubulin isotypes in microtubules’ functions.
A New Class of Autopoietic and Cognitive Machines
Authors: Mikkilineni Rao
Published: January 2022

Making computing machines mimic living organisms has captured the imagination of many since the dawn of digital computers. However, today’s artificial intelligence technologies fall short of replicating even the basic autopoietic and cognitive behaviors found in primitive biological systems. According to Charles Darwin, the difference in mind between humans and higher animals, great as it is, certainly is one of degree and not of kind. Autopoiesis refers to the behavior of a system that replicates itself and maintains identity and stability while facing fluctuations caused by external influences. Cognitive behaviors model the system’s state, sense internal and external changes, analyze, predict and take action to mitigate any risk to its functional fulfillment. How did intelligence evolve? what is the relationship between the mind and body? Answers to these questions should guide us to infuse autopoietic and cognitive behaviors into digital machines. In this paper, we show how to use the structural machine to build a cognitive reasoning system that integrates the knowledge from various digital symbolic and sub-symbolic computations. This approach is analogous to how the neocortex repurposed the reptilian brain and paves the path for digital machines to mimic living organisms using an integrated knowledge representation from different sources.
Dual Co-Attention-Based Multi-Feature Fusion Method for Rumor Detection
Authors: Bing Changsong , Wu Yirong , Dong Fangmin , Xu Shouzhi , Liu Xiaodi , Sun Shuifa
Published: January 2022

Social media has become more popular these days due to widely used instant messaging. Nevertheless, rumor propagation on social media has become an increasingly important issue. The purpose of this study is to investigate the impact of various features in social media on rumor detection, propose a dual co-attention-based multi-feature fusion method for rumor detection, and explore the detection capability of the proposed method in early rumor detection tasks. The proposed BERT-based Dual Co-attention Neural Network (BDCoNN) method for rumor detection, which uses BERT for word embedding. It simultaneously integrates features from three sources: publishing user profiles, source tweets, and comments. In the BDCoNN method, user discrete features and identity descriptors in user profiles are extracted using a one-dimensional convolutional neural network (CNN) and TextCNN, respectively. The bidirectional gate recurrent unit network (BiGRU) with a hierarchical attention mechanism is used to learn the hidden layer representation of tweet sequence and comment sequence. A dual collaborative attention mechanism is used to explore the correlation among publishing user profiles, tweet content, and comments. Then the feature vector is fed into classifier to identify the implicit differences between rumor spreaders and non-rumor spreaders. In this study, we conducted several experiments on the Weibo and CED datasets collected from microblog. The results show that the proposed method achieves the state-of-the-art performance compared with baseline methods, which is 5.2% and 5% higher than the dEFEND. The F1 value is increased by 4.4% and 4%, respectively. In addition, this paper conducts research on early rumor detection tasks, which verifies the proposed method detects rumors more quickly and accurately than competitors.
An Education Process Mining Framework: Unveiling Meaningful Information for Understanding Students’ Learning Behavior and Improving Teaching Quality
Authors: AlQaheri Hameed , Panda Mrutyunjaya
Published: January 2022

This paper focuses on the study of automated process discovery using the Inductive visual Miner (IvM) and Directly Follows visual Miner (DFvM) algorithms to produce a valid process model for educational process mining in order to understand and predict the learning behavior of students. These models were evaluated on the publicly available xAPI (Experience API or Experience Application Programming Interface) dataset, which is an education dataset intended for tracking students’ classroom activities, participation in online communities, and performance. Experimental results with several performance measures show the effectiveness of the developed process models in helping experts to better understand students’ learning behavioral patterns.
Effectiveness of Positive Deviance, an Asset-Based Behavior Change Approach, to Improve Knowledge, Attitudes, and Practices Regarding Dengue in Low-Income Communities (Slums) of Islamabad, Pakistan: A Mixed-Method Study
Authors: Shafique Muhammad , Mukhtar Muhammad , Areesantichai Chitlada , Perngparn Usaneya
Published: January 2022

Dengue is a mosquito-borne, viral disease that has emerged as a global health concern in recent years. In the absence of specific antiviral treatment and vaccines, prevention remains the key strategy for dengue control. Therefore, innovative and community-driven approaches are required to improve the vector control practices. This study applied and evaluated the positive deviance (PD) approach on dengue prevention and control in selected slums of Islamabad during June–October 2020. The two most dengue-affected slums, the Faisal colony and France colony, were purposively selected as intervention and control groups, respectively. A total of 112 participants (56 for the intervention and 56 for the control group) participated in the study. The intervention group was exposed for two months to locally identified role model behaviors through weekly interactive sessions, dengue sketch competitions, and role plays. Another two months enabled the community to practice these behaviors without any external support in order to explore the intervention’s sustainability. Three surveys were conducted: before the intervention, after two months, and after four months, to assess any changes in the knowledge, attitudes, and practices of participating communities. Results found that the PD intervention had a significant positive impact on dengue knowledge, attitudes, and practices in the intervention group. PD could offer an empowering and efficient community engagement tool for future dengue prevention and control, both in Pakistan and more globally.