bluuebunny/crossref_metadata_2025 huggingface dataset:
Congenital Adrenal Hyperplasia (CAH) - Causes, Diagnosis, Symptoms, Treatment
Authors: Targoński Oskar , Targońska Marta , Madej Adrianna , Suława Adrian , Furgalska Julia , Fedorowicz Sebastian , Basiak Aneta , Ptasiński Aleksander , Niekurzak Rafał , Buczek Agnieszka
Published: November 2024

Introduction and Purpose: Congenital adrenal hyperplasia represents a group of genetic disorders characterized by improper adrenal steroidogenesis, resulting in deficiency or absence of cortisol and/or aldosterone, and varying degrees of disturbances in sexual development. The aim of this study is to raise awareness about the disease, enabling early diagnosis and contributing to reducing neonatal mortality, as the first clinical manifestation of CAH can be the life-threatening salt-wasting syndrome.
 
State of Knowledge: Congenital adrenal hyperplasia (CAH), also known as congenital adrenal hyperplasia, encompasses a group of inherited disorders affecting the adrenal glands located above the kidneys. Adrenal glands produce various hormones, including cortisol, aldosterone, and androgens. CAH involves deficiencies in the enzymes necessary for the production of these hormones, leading to hormonal disturbances.
 
Summary: Congenital adrenal hyperplasia (CAH), also referred to as congenital adrenal hyperplasia (CAH), describes a group of genetic diseases causing defects in adrenal hormone synthesis. CAH results in deficiency or absence of cortisol and/or aldosterone. The most common causes are mutations in the CYP21 gene (21-hydroxylase deficiency), CYP11B2 gene (11β-hydroxylase deficiency), and HSD3B2 gene (3β-hydroxysteroid dehydrogenase deficiency). Enzymatic deficiencies lead to compensatory increases in CRH and ACTH secretion, causing adrenal hyperplasia and excessive androgen synthesis.
A Natureza Cautelar Da Suspensão De Direitos De Acionistas
Authors: Costa Norat Leonardo , Villela de Andrade Guilherme
Published: November 2024

O presente artigo se destina a responder como aferir a legalidade da medida de suspensão de direito de acionista que prevê o art. 120, da Lei 6.404/76 (Lei das Sociedades por Ações – LSA) e se justifica na amplitude da redação e na ainda escarça produção acadêmica específica sobre o dispositivo, apesar de sua potencialidade de aplicação prática. Para tanto, são desenvolvidos três tópicos, o primeiro é dedicado a analisar “estatuto do acionista”, considerando seus deveres e direitos, sobretudo os essenciais, de acordo com o artigo 109 da Lei das Sociedades Anônimas, o segundo se dedica a apresentar as características da medida prevista no artigo 120 da Lei 6.404/76, destacando e destrinchando seu conteúdo teleológico e o terceiro, a identificar como aferir a legalidade da medida adotada pela assembleia, a partir do controle jurisdicional. Adota-se o método dedutivo, com técnica de pesquisa bibliográfica e documental, e, de modo complementar, estudos de caso. Reconhecendo a medida como hipótese de autotutela, de natureza cautelar, portanto, essencialmente instrumental, concluiu-se que são quatro os critérios de aferição jurisdicional da legitimidade da tomada de decisão em sede de autotutela pela Assembleia Geral: (i) a validade da convocação assemblear; (ii) o pressuposto fático do inadimplemento; (iii) a proporcionalidade entre os meios adotados ante os fins acautelatórios pretendidos e (iv) a referibilidade (ou instrumentalidade) da medida adotada e do direito violado pelo descumprimento – que, a sua vez, pode desaguar em aferição comum com o i e o iii, mas cuja análise deverá correlativa com o iv, ante a causalidade entre o mecanismo e o direito tutelado pela via alternativa: ou seja, além de razoável, instrumental.
Relação de escuta da professora coordenadora com as crianças de uma escola de educação infantil
Authors: Zanfelice Natalí Angela , Chaluh Laura Noemi
Published: November 2024

O presente trabalho é recorte de uma pesquisa de mestrado realizada no ano de 2019, que teve como objetivo geral compreender a prática formativa da professora coordenadora atenta ao protagonismo infantil e ao protagonismo das professoras na escola. A referida pesquisa esteve articulada à perspectiva da pesquisa narrativa que legitima como objeto de estudo as próprias práticas dos docentes como forma de ampliar o conhecimento que circula e se produz na escola. Ainda, inspirada no paradigma indiciário como método interpretativo, procurou por indícios que revelassem de que forma o exercício da participação das crianças era potencializado nesse espaço escolar. Este artigo tem como objetivo ampliar o conceito de escuta discutido na pesquisa. Dessa forma são apresentadas três situações que dizem do exercício de escuta da professora coordenadora em relação às crianças e quais os desdobramentos desse movimento para os processos formativos junto às professoras. Destacamos a importância de um ambiente dialógico, no qual os adultos escutam o que as crianças têm a dizer e as consideram como sujeitos atuantes. Isso implica instituir no espaço escolar momentos de formação para institucionalizar práticas pedagógicas coerentes com a concepção de que seres humanos se pretende formar.
Produção curricular brasileira e suas interlocuções com a EPT e o currículo integrado
Authors: Soares Joice Pereira , Ramalho Brittes Letícia
Published: November 2024

Este trabalho apresenta uma discussão sobre a produção curricular brasileira na conjuntura neoliberal, analisando as influências desta na configuração da Educação Profissional e Tecnológica (EPT). Diante disso, desenvolveu-se um panorama sobre o tema da integração curricular, apresentando a instabilidade dos movimentos de integração e desintegração curriculares para o público dos Institutos Federais de Educação. Propõe-se, ainda, a dispersão das posições-sujeito que, conforme Laclau (2011), incitam novas formas de produção curricular que não estão necessariamente atreladas ao campo produtivo e às bases de pensamento progressista moderno. Na sequência, analisou-se as principais políticas curriculares da EPT brasileira no que tange às práticas articulatórias produzidas na negociação de sentidos para a implementação da integração curricular. A pesquisa é qualitativa e, como metodologia, foi usado um estudo bibliográfico. O artigo apresenta o debate na área da educação, centrado nas relações com a sociedade. Concluiu-se que a integração curricular está ligada a um conceito mais amplo de educação democrática, partindo dos problemas reais que incitam a participação dos estudantes na exposição das suas próprias experiências. E é nesta concepção que se assenta o entendimento de currículo justo: aquele que se abre à amplitude e ao apelo às práticas democráticas, configurando-se como um aspecto crucial da concepção do currículo integrado.
A educação e o campesinato:
Authors: De Oliveira Castro Andréia , Dos Santos Leonel Ronaldo , Sodré do Rosário Klebson Daniel
Published: November 2024

O presente estudo é resultado de múltiplas pesquisas e levantamentos realizados por um grupo de três pesquisadores(as) vinculados(as) ao grupo de pesquisa do Programa de Pós-Graduação em Educação e Ensino de Ciências na Amazônia (PPGEECA), da Universidade do Estado do Pará (UEPA). O objetivo central da pesquisa é fazer um breve resumo histórico das políticas públicas de educação no campo, entender sua importância ao longo dos anos, em consonância com os conceitos de Gramsci, e compreender como o Movimento dos Trabalhadores Sem Terra (MST) mobilizou-se para conseguir tais políticas públicas, a partir da década de 1990. Realizamos, em sua maioria, pesquisa bibliográfica e documental. Concluímos que a educação do campo, como prática libertadora, é empregada no processo de compreensão das lutas e demandas educacionais defendidas pelo MST. Ela interage com os gestos, desejos, valores e lutas pela terra, contribuindo para a construção de uma outra hegemonia que oriente a sua base militante.
The Effect of Morning Care Products Administration on Ethanol-Induced Hangover in Mice
Authors: Yoon Chanjin , Kim Hyo Keun , Ham Yu Seong , Yang Chul-Su
Published: November 2024

Hangovers, resulting from excessive alcohol intake, manifest hours after drinking, causing symptoms like thirst, headache, and fatigue. Alcohol is metabolized in the liver by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), with acetaldehyde and reactive oxygen species contributing to toxic effects. Morning Care (MC) products were evaluated in male and female mice to assess their impact on alcohol metabolism and hangover alleviation. The study revealed that pre-administration of MC products led to a significant reduction in blood ethanol and acetaldehyde concentrations postalcohol ingestion. This remarkable finding suggests a potential breakthrough in hangover relief. Enhanced ADH and ALDH activities were observed in blood and liver samples, indicating improved alcohol metabolism. Interestingly, gene expression levels of ADH and ALDH in the liver did not show significant differences, suggesting that MC products likely enhance enzyme activities through post-translational modifications rather than altering gene expression. These findings underscore the potential of MC products to mitigate hangover symptoms by enhancing alcohol metabolism.
"And You Just Happened to Find Me": The Turn to the Transcendent Relational in Tim Winton's The Shepherd's Hut
Authors: Arizti Bárbara
Published: November 2024

Abstract: This article explores the concept of the transcendent relational through the analysis of the encounter between the two main characters of Tim Winton's The Shepherd's Hut . The transcendent relational names a new understanding of transcendence characteristic of transmodernity, the sociocultural paradigm that has succeeded postmodernity. It draws on the synergies between caring individualism and immanent transcendence, both distinctive features of transmodern times (Rodríguez Magda). The study of Winton's novel proves that relationality of a higher order is needed for the experience of the dimension of reality that goes beyond the strictly human and the material. It is also symptomatic of a growing interest in transcendence that does not rule out institutionalized religion but, most characteristically, implies an intimate search outside creeds and dogmas.
Controllable Brillouin laser and Brillouin-Kerr microcombs
Authors: Kuang Quanjin , Xie Chengfeng , Wang Mengyu , Ouyang Feng , Guo Zhuang , Wei Bin , Shi Jiulin , He Xingdao
Published: November 2024

Backward-stimulated Brillouin scattering (SBS) in microcavities has sparked interest in nonlinear optical physics and its associated applications. In this study, utilizing a hybrid microsphere cavity experimental platform, we showcase the remarkable tunability of thermal tuning in nonlinear SBS. We present a compact, low-cost, tunable cascade Brillouin laser source, demonstrating, for the first time, up to seven orders of cascade in SBS by varying the control power. Flexible switching of the Brillouin laser is achieved by changing the control power. Furthermore, the Brillouin-Kerr comb, generated by Brillouin-coupled four-wave mixing, also enables free switching of comb states. Specifically, soliton microcombs and microcombs with flat profiles are realized at specific control powers. This study on SBS boasts an ultra-high repetition rate and offers a novel solution for controlled Brillouin lasers and Brillouin-Kerr soliton microcombs, laying a new foundation for Brillouin laser spectroscopy and the utilization of Brillouin-Kerr soliton microcombs in related applications.
Dynamic light field reconstruction via densely connected deep equilibrium model
Authors: Wang Ruixue , Wang Xue , Xiao Zhaolin , Wang Qing
Published: November 2024

High-resolution consumer plenoptic cameras usually feature low frame rates, making them not well-suited for capturing high-speed motion scenes. To compensate for this limitation, we extend the original snapshot compressive imaging system to plenoptic cameras and propose a densely connected deep equilibrium (DEQ) model for high-quality dynamic light field (LF) reconstruction, abbreviated as DLFDEQ. Specifically, we perform temporal compression encoding on a dynamic LF and model the reconstruction process as an inverse problem with an implicit regularization term. To solve this inverse problem, we present a densely connected DEQ model based on gradient descent. Our approach demonstrates stronger robustness and better detail retention than existing methods. We can practically quadruple the original camera’s frame rate by continually capturing and retrieving these measurement frames with high reconstruction accuracy.
Dynamic Blazed Grating Mechanism in An Air Gap Tunable Terahertz Metasurface Based Dynamic Beam Steering Device
Authors: Hossain Fahim Ferdous , Choi Yun-seok , Azad Abul , O'Hara John
Published: November 2024

Next-generation wireless sensing and communication will require efficient terahertz beam steering to enhance spatial coverage and establish non-line-of-sight links. Beam steering can be achieved using tunable metasurfaces, and the air gap tunable metasurfaces are particularly promising due to their good performance and high efficiency, resulting from the absence of lossy material in the tuning gap. In this article, we present an air gap tunable terahertz metasurface designed to operate primarily at 145 GHz. Importantly, we show that this device constitutes a terahertz blazed grating, whose blaze angle is dynamically tuned by adjusting the metasurface air gap. This enables a continuous, low-loss selection of the fractions of energy radiated in the zeroth and first diffraction orders. The device’s operation has been characterized experimentally, and the results confirm the dynamic blazed grating mechanism. The theoretical foundation is also shown to reveal the functional limitations of this mechanism in beam steering.
Lived experiences of families of meningitis patients and survivors in the Upper West Region of Ghana
Authors: Punguyire Damien , Naawa Ambrose , Baatiema Linus , Aabalekuu Simon , Koray Munawar Harun , Mawupemor Avevor Patrick , Ohene Sally-Ann
Published: November 2024

Meningitis is a fatal condition and survivors often face long-term effects and often burdened their families. It is therefore important to understand how families cope with the aftermath of the infection. This study examined the experiences of families of meningitis patients and survivors in Ghana’s Upper West Region to support public health interventions. The researchers employed a Giorgi phenomenological qualitative method to conduct the study between March and April 2023. Data were collected from 40 facilities and four District Health Directorates. Sixteen participants, including survivors and parents, were selected from meningitis linelists. The study employed content analysis, with a coding system revealing five main themes. Inter-coder reliability was checked, and peer debriefing was used to ensure credibility. The study identified five main challenges: reduced productivity, inability to perform labor-intensive work, financial strain on households, psychological trauma, and the impact of social support. These experiences highlight the subjective nature of post-meningitis challenges and are consistent with existing literature. Meningitis survivors and their families face physical, emotional, and financial challenges, which can have long-term impacts. However, social support plays a crucial role in resilience and recovery. The study recommends that health institutions establish follow-up programs to monitor long-term effects on survivors.
Renewable energy for sustainable development in China: Discourse analysis
Authors: Jiang Baohong , Raza Muhammad Yousaf
Published: November 2024

China is the world’s largest renewable energy installer with a capacity of 1020 gigawatts in 2021. This study aims to analyze the public discourse around China’s green energy and green technology and the paths to sustainable development by comparing public policy. The public discourse analysis approach and Grey Prediction Model are applied to analyze the motives for the distinct inferences being reached over the influences of renewable energy initiatives (REIs). The findings show that the modeling and assumptions are found different in theoretical perspectives, especially in the case of economic and environmental sustainability. The results are close to the other jurisdictions following REIs, including feed-in-tariff, standards and renewable liabilities. Based on statistics during 2012–2021 Five-year plan period, three major renewables are forecasted under base, reference and aggressive scenarios with interesting results. The wind would rise by 109 terawatt hours in an aggressive scenario while solar will rise from 83–99% with a rise of four times in the next decade. Finally, China’s current energy policy has been proven to be a series of effective public policies by making the discourse analysis, which can energetically widen the subsidy funds’ sources, discover miscellaneous financing techniques, standardized the subsidy process, supervise in applying the renewable energy technologies, and enhance the feed-in-tariff attraction of consumers and private investors.
RHRVEasy: Heart rate variability made easy
Authors: García Constantino A. , Bardají Sofía , Pérez-Tirador Pablo , Otero Abraham
Published: November 2024

Heart Rate Variability (HRV) analysis aims to characterize the physiological state affecting heart rate, and identify potential markers of underlying pathologies. This typically involves calculating various HRV indices for each recording of two or more populations. Then, statistical tests are used to find differences. The normality of the indices, the number of groups being compared, and the correction of the significance level should be considered in this step. Especially for large studies, this process is tedious and error-prone. This paper presents RHRVEasy, an R open-source package that automates all the steps of HRV analysis. RHRVEasy takes as input a list of folders, each containing all the recordings of the same population. The package loads and preprocesses heart rate data, and computes up to 31 HRV time, frequency, and non-linear indices. Notably, it automates the computation of non-linear indices, which typically demands manual intervention. It then conducts hypothesis tests to find differences between the populations, adjusting significance levels if necessary. It also performs a post-hoc analysis to identify the differing groups if there are more than two populations. RHRVEasy was validated using a database of healthy subjects, and another of congestive heart failure patients. Significant differences in many HRV indices are expected between these groups. Two additional groups were constructed by random sampling of the original databases. Each of these groups should present no statistically significant differences with the group from which it was sampled, and it should present differences with the other two groups. All tests produced the expected results, demonstrating the software’s capability in simplifying HRV analysis. Code is available on https://github.com/constantino-garcia/RHRVEasy.
Differential effects of prenatal alcohol exposure on brain growth reveals early upregulation of cell cycle and apoptosis and delayed downregulation of metabolism in affected offspring
Authors: Sambo Danielle , Kinstler Ethan , Lin Yuhong , Goldman David
Published: November 2024

Fetal Alcohol Spectrum Disorder (FASD) encompasses the deleterious consequences of Prenatal Alcohol Exposure (PAE), including developmental delay, microcephaly, dysmorphologies, and cognitive and behavioral issues. The dose and timing of alcohol exposure, maternal and environmental factors, and genetics all impact FASD outcomes, but differential susceptibility and resiliency to PAE remains poorly understood. In this study, we examined the differential effects of PAE during early mouse development on brain growth and gene expression. Brains were weighed and collected either 24 hours or five days after treatment. We then performed transcriptomics to determine whether offspring differentially affected by PAE, by brain weight, also differ in gene expression, despite having the same genetic background, alcohol exposure, and maternal factors. We found within litter variation in brain weights after PAE, and classified offspring as having normal, middle, and low-weight brains relative to saline-treated controls. The normal-weight brains showed no significant differences in gene expression, suggesting these offspring were both phenotypically and transcriptionally unaffected by PAE. While both middle- and low-weight brains showed changes in gene expression, the middle-weight brains showed the most robust transcriptome differences. Twenty-four hours after PAE, we saw an upregulation of cell cycle and apoptosis in affected offspring, whereas at roughly a week later, we saw a downregulation of metabolic processes. Overall, these findings highlight variability in response to PAE and demonstrate the molecular processes involved in offspring phenotypically affected by alcohol.
Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response
Authors: Xue Wenxiang , Chu Hongyan , Wang Jiehuang , Sun Yingjie , Qiu Xusheng , Song Cuiping , Tan Lei , Ding Chan , Liao Ying
Published: November 2024

The hallmark of coronavirus infection lies in its ability to evade host immune defenses, a process intricately linked to the nuclear entry of transcription factors crucial for initiating the expression of antiviral genes. Central to this evasion strategy is the manipulation of the nucleocytoplasmic trafficking system, which serves as an effective target for the virus to modulate the expression of immune response-related genes. In this investigation, we discovered that infection with the infectious bronchitis virus (IBV) dynamically impedes the nuclear translocation of several transcription factors such as IRF3, STAT1, STAT2, NF-κB p65, and the p38 MAPK, leading to compromised transcriptional induction of key antiviral genes such as IFNβ, IFITM3, and IL-8. Further examination revealed that during the infection process, components of the nuclear pore complex (NPC), particularly FG-Nups (such as NUP62, NUP153, NUP42, and TPR), undergo cytosolic dispersion from the nuclear envelope; NUP62 undergoes phosphorylation, and NUP42 exhibits a mobility shift in size. These observations suggest a disruption in nucleocytoplasmic trafficking. Screening efforts identified the IBV nucleocapsid (N) protein as the agent responsible for the cytoplasmic distribution of FG-Nups, subsequently hindering the nuclear entry of transcription factors and suppressing the expression of antiviral genes. Interactome analysis further revealed that the IBV N protein interacts with the scaffold protein RACK1, facilitating the recruitment of activated protein kinase C alpha (p-PKCα) to RACK1 and relocating the p-PKCα-RACK1 complex to the cytoplasm. These observations are conserved across diverse coronaviruses N proteins. Concurrently, the presence of both RACK1 and PKCα/β proved essential for the phosphorylation and cytoplasmic dispersion of NUP62, the suppression of antiviral cytokine expression, and efficient virus replication. These findings unveil a novel, highly effective, and evolutionarily conserved mechanism.
Human norovirus disturbs intestinal motility and transit time through its capsid proteins
Authors: Cuvry Arno , Molineaux Lorane , Gozalbo-Rovira Roberto , Neyts Johan , de Witte Peter , Rodríguez-Díaz Jesús , Rocha-Pereira Joana
Published: November 2024

Human norovirus (HuNoV) accounts for over 700 million cases of gastroenteritis annually. Episodes of HuNoV disease are characterized by vomiting and diarrhea as the two most prominent symptoms. Despite its prevalence, our understanding of the pathophysiological mechanisms triggered upon HuNoV infection is limited, mainly due to a lack of suitable animal models. Our aim was to use the recent HuNoV zebrafish larvae model to study the effect of HuNoV infection on intestinal motility and investigate whether one viral protein could act as an enterotoxin, as seen with rotavirus. We studied whether HuNoV infection affects the contraction frequency of the intestinal bulb and the posterior intestine as well as the transit time. Infection of larvae, following injection of a HuNoV GII.4-containing stool sample in the yolk, resulted in an increased contraction frequency in the intestinal bulb. A comparable effect was observed in serotonin-treated larvae, corresponding to the natural function of serotonin. The higher replication efficacy of HuNoV GII.4 likely explains why they have a more marked effect on gut motility, when compared to other genotypes. Additionally, transit time of fluorescent food was prolonged in HuNoV GII.4 infected larvae, suggesting a loss of coordination in bowel movements upon infection. To identify the proteins responsible for the effect, individual HuNoV non-structural proteins and virus-like particles (VLPs) were injected intraperitoneally (ip). VLPs carrying VP1/VP2, but not those with only VP1, induced increased contraction frequencies in the intestinal bulb in a dose-dependent manner. In conclusion, our findings suggest that the viral capsid and potentially the minor capsid protein VP2 play a crucial role in the aetiology of symptoms associated with HuNoV, potentially acting as a viral enterotoxin. This work contributes to the understanding of the pathophysiological mechanisms in HuNoV-induced disease and further attests zebrafish as a valuable HuNoV disease model.
From Manufacturing Decline to the Rise of Consultancy
Authors: Nieto-Carrillo Ernesto
Published: November 2024

Since the creation of Quadros de Pessoal (QP) in 1981, a longitudinal employer-employee dataset encompassing all Portuguese firms, four different industrial classification methodologies have been in place. These changes have hindered the ability to conduct long-term inter-industry studies on firm dynamics and structural change. This paper presents a framework for transforming the QP into a dataset with time-consistent two-digit industry codes and examines shifts in the firm-level growth rate distribution, net job creation and employment composition across sectors. Our industry-consistent trends confirm the contraction of the manufacturing sector, which coincided with the expansion of the services sector. While the increased business dynamism and net job creation in activities arising from the ICT revolution played a critical role, the technological paradigm shift in Portugal appears to be predominantly reflected in the vertical disintegration of firms and the subsequent substantial growth of administrative support services.
Growth and Convergence in Portugal
Authors: Vinhas de Souza Lúcio
Published: November 2024

Contrary to other EU countries, Portugal has become relatively poorer for almost a quarter of century. Growth decomposition exercises show that this is due to a reduction in capital accumulation and a sharp fall in total factor productivity. There are areas in which the country can act to reduce the fall, by capitalizing on national comparative advantages and the diverse but complementary features of its two largest metropolitan regions, Lisbon and Porto. However, this requires policy changes.
Los protagonistas del No-Do en la educación formal (1943-1981)
Authors: Molina Poveda María Dolores
Published: November 2024

El 4 de enero de 1943 se estrenaba en los cines españoles un noticiario elaborado por no-do. Esta entidad también produjo otros productos en los que trataban diferentes temas, siendo uno de ellos la educación. El objetivo de este estudio es conocer qué se mostró de la educación formal no universitaria en el no-do y para ello se ha utilizado el método histórico-educativo. no-do mostró noticias, reportajes y documentales sobre todos los niveles educativos, la educación físico-deportiva y la promulgación de la Ley General de Educación en 1970, aunque unos niveles tuvieron un mayor protagonismo que otros como, por ejemplo, la Formación Profesional, que destacó sobre el resto de niveles; o la Educación Preescolar, que fue la menos mostrada. Esta entidad transmitió una imagen cíclica de los acontecimientos, aunque no pudo escapar a los cambios educativos que se estaban produciendo, a pesar de que la educación tradicional continuó siendo la protagonista.
Participação social
Authors: Lima Stella Aparecida Geraldo
Published: November 2024

As construções coletivas se dão em diferentes espaços, no contexto do Estado, temos as instâncias de participação social, normatizadas nas políticas sociais como locais em potência para fortalecer o Sistema Único de Saúde – SUS. Este artigo busca apresentar um projeto de pesquisa que visa compreender e repensar os limites e possibilidades da participação social no SUS com respaldo no pensamento de Floreal Antonio Ferrara. Para tal foi realizada uma revisão bibliográfica em revistas marxistas e de tradição crítica com vistas a compreender o termo “participação social”, assim como, buscou-se explorar limites e possibilidades deste campo institucionalizado na política de saúde, com respaldo no pensamento de Floreal Antonio Ferrara. Pretendemos explicitar criticamente o termo “participação social” e seus semelhantes para promover uma discussão crítica sobre os limites e possibilidades institucionais desta prática, bem como, repensá-la.
Recurrent bladder malakoplakia: A rare bladder lesion mimicking malignancy
Authors: Tinguria Mukund
Published: November 2024

Background: Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract with the urinary bladder being the most frequently affected site. It is characterized by histiocytes containing distinct basophilic calcified inclusions called Michaelis–Gutmann bodies. It is believed to result from abnormally functioning macrophages, with inclusions representing calcifications around incompletely digested bacteria. Although its pathogenesis remains unknown, it is well-documented that the condition is associated with chronic urinary tract infections and immunosuppression. Grossly, it can present as soft, yellow plaques, nodules, bladder mass, or even without any visible lesion. It poses a huge diagnostic challenge as it tends to mimic malignancy. Case presentation: Described here is an 86-year-old female with recurrent bladder malakoplakia who presented with foul-smelling urine, hematuria, and dysuria. The clinicopathological features of this rare bladder lesion are described along with a review of the literature. Conclusion: Early identification of malakoplakia’s features by pathologists is essential for effective patient management. This condition should be considered in the differential diagnosis of bladder lesions, especially when Escherichia coli is present.
Geographic information system mapping and predictors of glycemic control in children and youth with type 1 diabetes: a study from Western India
Authors: Yewale Sushil , Chaudhary Navendu , Miriam Demi , Bhor Shital , Dange Nimisha , Shah Nikhil , Khadilkar Vaman , Khadilkar Anuradha
Published: November 2024

Objectives

Geographic Information System (GIS) mapping, is a novel way to provide insights into spatial distribution of type 1 diabetes (T1D) and associations between T1D outcomes and potential predictors. We aimed to explore GIS in children with T1D, and identify predictors of poor glycemic control.

Methods

Design: Cross-sectional; Participants: 402 children and youth (187 boys) with T1D. Place of residence (coordinates) of participants were geocoded in GIS. They were divided into two groups living in urban or peri-urban areas using ArcGIS Pro. The characteristics of urban/peri-urban living were linked to sociodemographic and biochemical data and spatial autocorrelation analysis was performed. Association between glycemic control and distance to our unit was studied.

Results

Mean age was 13.2 ± 4.7 years; 196 children were living in urban areas, 206 in peri-urban areas. There was significant difference in HbA1c between groups (Urban 9.9 (9.7, 10.2) %, Peri-urban 10.5 (10.1, 10.8) %) (p=0.004); mean difference 0.5 (0.1, 1.0) with poorer glycemic control and higher prevalence of vitamin D sufficiency in peri-urban and higher prevalence of hypothyroidism in urban areas. There was significant correlation between glycemic control (HbA1c) and distance to our unit r=0.108 (0.023, 0.218) (p=0.031). Individuals with an HbA1c ≥9.5 were residing farther away (58.9 (49.4, 68.5) km) as compared to those with HbA1c <9.5 (44.5 (35.1, 53.9) km) (p<0.05).

Conclusions

Children with T1D when grouped using GIS had differences in glycemic control and comorbidities; peri-urban participants and those residing further away from our unit had poorer glycemic control. Future efforts may be aimed at identifying centers and channelizing resources towards children showing poor glycemic control, thus optimizing disease management.
Humanitarian interpreting in the context of African migrant reception in the Canary Islands
Authors: García-Morales María Goretti , González Leticia Fidalgo
Published: November 2024

The Canary Islands have traditionally been known for their beautiful beaches and tourist resorts. However, in the last decades, African migrant reception in this territory has become a human rights issue, which requires attention from all those involved in providing infrastructure, medical assistance, integration opportunities, etc. At the base of any of these actions is communication. Assisting migrants as soon as they arrive in Spanish territory, is certainly a new context where both language and cultural barriers are present.In this article we aim to describe the characteristics of the so-called Atlantic route in the context of irregular migration by sea, with a view to justifying its designation as a humanitarian crisis context and the consequent need to address this situation by providing suitable interpreter training for both ad hoc interpreters and those involved in interpreter education. We will also describe the main differences in the role played by interpreters and cultural mediators, with a special focus on ethical principles attached to the interpreting profession. Finally, after presenting some of the challenges in current communication practices with people arriving on the coasts of the Canary Islands, we will discuss whether translation and interpreting services should adapt to this specific situation.
Sleep Hygiene Within the Fire Service: A Narrative Review
Authors: Hare McKenzie M. , Wohlgemuth Kealey J. , Mota Jacob A.
Published: November 2024

Firefighters are valuable members of society, prioritizing and assisting in public safety. Although the occupation is physically demanding, firefighters are at great risk of cardiovascular disease compared with the general population. Although cardiovascular disease, obesity, and hypertension are preventable, the risk remains prominent in the fire service. Firefighters respond to emergencies throughout the day and night, causing disruptions and insufficient sleep, which may hinder their health and ability to accomplish occupational tasks. Adequate sleep quantity and quality are vital for both cognitive functioning and performance. Decrements in sleep duration or quality may have immediate detrimental impacts on firefighters' ability to perform occupational duties and further increase the risk of injury. Furthermore, poor sleep habits also negatively affect chronic health, heightening the precedented health concerns of this population. Understanding the effects of poor sleep hygiene and how to counteract inadequate sleep may reduce the risk of chronic health problems and allow firefighters to consistently accomplish occupational performance tasks. This narrative review describes the effects of poor sleep and the implication of quality sleep hygiene regimens that may provide the fire service.
“All Crookedly Blessed in God’s Mercy”
Authors: Conniff Brian P.
Published: November 2024

Bruce Springsteen has repeatedly reinvented himself through a long process of vocational discernment that often draws on a distinctly Catholic imagination. In this process, he has repeatedly explored complex relationships between religious faith, American identity, older traditions of popular music, and race. At pivotal moments in his career, his vocational discernment has led him to the work of musicians raised in Pentecostal and Holiness churches. From this perspective, this essay explores the relationship between Springsteen’s “Land of Hope and Dreams” and Sister Rosetta Tharpe’s “This Train,” the gospel-inspired song that she first recorded in 1938. Both of these songs arise from Christian imaginations nurtured in local communities of faith—in Tharpe’s case, a congregation of the Church of God in Christ in Cotton Plant, Arkansas, and in Springsteen’s case, an immigrant Catholic parish in Freehold, New Jersey. Tharpe draws directly from Holiness traditions, combining her belief in a distinctly embodied version of sanctification with the religious practice of tongues speaking, most powerfully in her guitar improvisations. Like Springsteen, Tharpe brings to contemporary music the performance dynamics of Holiness and Pentecostal preachers, possessed by the Holy Spirit, accompanied by a choir, before an enraptured congregation. In these respects, the resemblances between these two songs are not a matter of “direct influence.” Rather, these resemblances provide a critical test case in a kind of artistic influence that is multi-directional, unpredictable, and often subversive. They arise from shared sources, particularly a long tradition of train songs that find their way into country and gospel music. Even more important, they arise from similarities in the faith traditions—and the religious imaginations—of the two musicians. From this perspective, Tharpe and Springsteen both belong to a larger tradition of “gospel redemption” in American popular music, which becomes particularly evident when “Land of Hope and Dreams” ends with a cover of Curtis Mayfield’s “People Get Ready,” invoking the ideals of the early civil rights movement and, at the same time, our repeated failures to achieve these ideals.
A Mutual Project: Architecture and the Imperial Foundations of American Missionaries in Nineteenth-Century Beirut
Authors: El Chami Yasmina
Published: November 2024

This article focuses on the construction of the Syrian Protestant College from its foundation in 1863 to the beginning of the twentieth century and resituates American missionaries as covert imperial actors in nineteenth-century Beirut. It examines the close relationship between the missionaries’ increasingly imperial ambitions and their architectural establishment in the city, as evidenced by the private correspondence of the college’s founders. Here, architecture was neither a simple projection of “American” or evangelical culture nor a materialization of direct colonial control. Rather, architecture was tasked with multiple evolving roles as the missionary project grew more secure. This article traces the development of the college and its campus through three phases to illustrate how architecture and the missionaries’ imperial ambitions became mutually constitutive over time. In elucidating the nineteenth-century imperial foundations of the Syrian Protestant College it reconsiders both the nature of American imperialism in the Middle East and the central role of architecture in its construction.
Beyond Sustainable Development, to Sustainable Societies
Authors: Desai Manisha
Published: November 2024

Drawing on feminist, indigenous, and abolitionist thinkers, I suggest that we need a fundamental transformation in how and what we produce, consume, redistribute, and how we relate to each other and to all living and nonliving entities on this earth. This means going beyond sustainable development, a one-size-fits-all model based on neoliberal, market-based growth, to conceptualize place- and culture-specific sustainable societies. I define sustainable societies along three dimensions: economic, epistemic, and political.
Environmental Spending and Forest Loss
Authors: Harper Marion C. , Restivo Michael , Shandra John M. , Sommer Jamie M.
Published: November 2024

Since the early 2000s, environmental-state research has focused on the unique capacity and positionality of the state to address environmental degradation and sustainability. More recently, there has been a call in the literature to consider empirically how the environmental state has impacted the environment cross-nationally. We respond to this call by testing the hypothesis that more government spending for environmental protections corresponds with less forest loss in low- and middle-income nations. We use ordinary least squares regression on a sample of 70 nations. Our results support the idea that low- and middle-income nations can address environmental issues.
ФИЛИППОВСКИЙ НАСТАВНИК СИМЕОН ГАВРИЛОВ КАК КНИЖНИК
Authors: Е.М. ЮХИМЕНКО
Published: November 2024

Статья посвящена видному деятелю старообрядчества последней трети XIX - начала XX в. - северодвинскому крестьянину Симеону Гаврилову, наставнику филипповского согласия, книжнику, писателю, составителю четырех родословных. На основе новых материалов уточняются некоторые факты его биографии, в частности касающиеся времени пребывания на московском Братском дворе (конец 1873-1879), поездки в Сибири (1900). Сохранившиеся материалы Симеона Гаврилова - его сочинения, сборники, выписки - наглядно показывают широту книжных интересов филипповского наставника, глубину его познаний, не ослабевающий с годами интерес к разысканию нового материала. Работу северодвинского книжника характеризует вполне осознанный источниковедческий подход: оценка авторитетности источника, поиски авторских списков, сравнительный анализ списков, археографические комментарии. Все это служит ярким свидетельством сохранения в старообрядческой среде традиционного типа книжника-начетчика.

The article is devoted to the prominent figure of the Old Believers of the last third of the 19th - early 20th centuries - Severodvinsk peasant Simeon Gavrilov, mentor of the Filippovsky consent, scribe, writer, compiler of four Genealogies. Based on new materials, the article clarifies some of the facts of his biography, in particular, concerning the time of his stay in the Moscow Bratsky Dvor (the end of 1873 - 1879), trip to Siberia (in 1900). Simeon Gavrilov was a member of the circle of authoritative Filippovsky mentors and had access to the archives of the Bratsky Dvor and other mentors. He searched for books and documents on the history of consent wherever he was: in Moscow, Yegoryevsk, Kimry, Siberia. The surviving materials of Simeon Gavrilov - his writings, collections, extracts - clearly show the breadth of his book interests, the depth of knowledge, and the interest in finding new material that has not weakened over the years. The work of the Severodvinsk scribe is characterized by a completely conscious source study approach: assessment of the authority of the source, searches for author’s copies, comparative analysis of copies, archaeographic comments. As a scribe and copyist, Simeon Gavrilov was distinguished by his great punctuality and perfectionism. All this serves as clear evidence of the preservation of the traditional type of scribe-dogmatist in the Old Believer environment.
Mechanical Ventilation for Children Approaching End of Life: A PHIS Study, 2010–2019
Authors: Puccetti Deirdre F. , Staffa Steven J. , Burns Jeffrey P.
Published: November 2024

OBJECTIVE

To determine the prevalence of invasive and noninvasive mechanical ventilation (IMV and NIV) for children who die in the hospital, to assess for change over time, and to determine the association between mode(s) of ventilation and hospital resource utilization.

METHODS

Multicenter retrospective cohort of 37 children’s hospitals in the United States participating in Pediatric Health Information Systems Database. Included 41 091 hospitalizations for patients 0 to 21 years who died in hospital January 2010 to December 2019. Univariate and multivariate logistic regression examined IMV and NIV use clustered by hospital, adjusting for demographic and clinical characteristics. χ2, Kruskal-Wallis tests and multivariable regression models measured associations between mode of ventilation and resource utilization.

RESULTS

Over the decade, the percentage exposed to any IMV remained unchanged (∼88.5%), whereas any NIV increased 7.1% (18.8% to 25.9%), with wide interhospital variability in NIV use. Exposure to both IMV + NIV increased 6.0% (16.8% to 22.8%). Compared with only IMV, only NIV had lower odds of ICU admission and death, shorter ICU length of stay (LOS), similar hospital LOS, and lower costs. Both IMV + NIV had higher odds of ICU admission, longer duration of IMV, lower likelihood of ICU death, longer ICU and hospital LOS, and higher costs than IMV alone.

CONCLUSIONS

For children who died in the hospital in the past decade, use of NIV has increased without a reciprocal decrease in IMV, because of an increase in exposure to both IMV + NIV, a combination associated with high hospital resource utilization.
Epidemiological dynamics at the peak of the COVID-19 pandemic among children in Rio Grande do Sul, Brazil
Authors: Miotto Lorenzetti Débora , Souza Luiza , de Oliveira Godoy Natália , Gosch Berton Giovanni , Barelli Cristiane , Da Luz Barbosa Gilberto , Bruno Zilli Julcemar , Bertol Graeff Daniela
Published: November 2024

Objective: to describe the profile of children infected by SARS-CoV-2 in Rio Grande do Sul, Brazil, between March 1, 2020, and April 30, 2021, comparing infection rates and disease evolution stratified by age group. Methods: this cross-sectional study used data from COVID-19-confirmed cases from a public state database in children aged zero–nine. Results: the study sample comprised 35,131 children. We found the highest infection rate in the age group of zero–four years old, 3.8% (95%CI:3.3%-4.3%). Of the patients, 3.8% (n = 1,323) had comorbidities, the most prevalent being respiratory tract disease (56.2%, n=829). 450 (1.3%) children developed Severe Acute Respiratory Syndrome (SARS), with a lethality rate of 0.05% (95%CI:0.02%-0.08%). However, we found that both outcomes decreased when age increased; thus, a PR of 8.68 (CI95%:6.86-10.99) was estimated for SARS and PR=5,52 (CI95%:1,26- 24,09) for death in the presence of respiratory comorbidity. Discussion: this study revealed a low mortality rate in this population. The presence of respiratory comorbidities increases the risk of SARS and death. Both outcomes increased in younger age groups.
O meu mundo refletido nos teus olhos
Authors: Fernandes de Santana Wilder Kleber , Primo Delanoy Claudio
Published: November 2024

Este trabalho delimitou como objetivo analisar a constituição emancipatória da personagem Anne de Green Gables, em que pretendemos averiguar os posicionamentos axiológicos assumidos por Anne Shirley, e de que forma seu mundo se reflete e se refrata na vida. Bakhtin e o Círculo apresentaram os fundamentos para o princípio dialógico da linguagem e a identidade do sujeito, em dimensões plural, viva e dinâmica. Em prisma dialógico, o sujeito tem sua identidade discursiva construída através de seu(s) outro(s) em zona fronteiriça. Com base nos estudos de Bakhtin e do círculo, articularam-se suas principais produções teóricas (sujeito, linguagem, identidade), as quais nos permitam apresentar os pilares do dialogismo. Para subsidiar as análises empreendidas, recorremos a Mikhail Bakhtin (1895-1975), Pável N. Medviédev (1891-1938) e Valentin N. Volóchinov (1895-1936), integrantes do Círculo de Bakhtin, além de interlocutores em terreno brasileiro (Brait, 2005, 2006; Delanoy, 2020, 2024; Santana, 2021). Do ponto de vista metodológico, este estudo caracteriza-se como uma pesquisa qualitativa de base interpretativista e caráter descritivo/explanatório, apresentando como corpus de análise três cenas específicas da série da Netflix “Anne with an E”. Os resultados demonstraram que Anne se constitui como uma adolescente/jovem à frente do seu tempo, criativa e insubmissa ao patriarcado, a qual encontra, na imaginação, fonte inesgotável de renovação de vida.