bluuebunny/crossref_metadata_2025 huggingface dataset:
URINE CYTOKINES ARE NONINVASIVE MARKERS OF CLINICAL AND LABORATORY REMISSION IN CHILDREN WITH CHRONIC PYELONEPHRITIS
Authors: Slobodian E. I. , Kaladze N. N. , Govdalyuk A. L.
Published: December 2018

THE AIM:to evaluate diagnostic significance of clinical and laboratory resistance in determining urine cytokines in patients with chronic pyelonephritis (CP).PATIENTS AND METHODS.This prospective study included 110 children with CP aged 6 to 16 years in a state of clinical and laboratory remission. The control group consisted of 20 apparently healthy children. Laboratory tests used to determine EGF, TGF-β1, IGF-1, β2 – MG, IL-4, IL-10, IL-17 and IL-12 by ELISA in the morning urine of patients.RESULTS.Comparison of cytokines values depending on the clinical form of the disease revealed the prevalence of levels of TGF-β1 and IL-17 in the urine of patients with obstructive CP. The highest uTGF-β1 / uCr and uIL-17 / uCr were obtained in patients, which have vesicoureteral reflux in anamnesis. Level uIL-10 / uCr almost 2 times was elevated in children with both clinical forms of CP. In patients with the disease experience up to 6 years, were identified unidirectional changes of urine cytokines – increase in both pro- and anti-inflammatory parameters. As the duration of the microbial-inflammatory processes more than 6 years there was a significant decrease in the levels uIGF-1 / uCr and uEGF-1 / uCr relative to the control group, with no significant changes in the uIL-12 / uCr and uIL-10 / uCr at continuing higher levels uTGF-β1 / uCr, uIL-17 / uCr, uIL-4 / uCr. In patients having one or less exacerbation of CP per year, regardless of the duration of the disease, no pathological changes in cytokine levels have been detected. Most of the studied parameters were dependent on renal function.CONCLUSION.Increased concentration of studied urine cytokines indicates the presence of a latent inflammatory process more than in half of studied patients.
WELCOME TO THE PARTICIPANTS OF THE FORUM
Authors: Shilov E. M. , Dedov V. V.
Published: December 2018

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Microbiological diagnosis of postpartum endometritis
Authors: Korobkov N. A.
Published: December 2018

The objective of the study was to compare the uterus microflora in healthy women and in the patients with postpartum endometritis using the method of quantitative assessment of contamination of the material. Further examination revealed polymicrobial etiology of the postpartum endometritis. The leading role in the etiological structure belongs to opportunistic microorganisms: enterococci, enterobacteria (preferably Enterococcus faecalis and Proteus mirabilis), and non-spore forming anaerobes (predominantly - Peptostreptococcus spp. аnd Bacteroides spp.), located in the uterus, in most cases, a bulk quantity as aerobically-anaerobic associations.
Indices of psychic status in the people with regular and irregular rhythm of the intestine
Authors: Shemerovsky K. A.
Published: December 2018

The level of neuropsychic adaptation and regularity of the circadian rhythm of the evacuatory function of the intestine were investigated in the working people. The people were divided - according to the psychic state - into 4 main groups: I - practically healthy people - 22 %, prenosologic condition - 22 %, III - pre-pathologic condition - 27 %, IV - pathology condition - 29 %. The people with the irregular rhythm of the intestine demonstrate worsening of the psychic state from 2 to 6 times more frequently than in the people with a regular rhythm of the intestine.
Comparative assessment of the indices of the left ventricle post-infarction remodelling of the left ventricle and its dependence on the strategy of acute myocardial infarction management
Authors: Zhidovich D. M. , Shcheglova L. V.
Published: December 2018

Comparative assessment of the indices of post-infarction remodelling of the left ventricle was carried out in the patients with myocardium reperfusion (thrombolytic therapy) and without reperfusion. ECG was performed for all patients on admission to the hospital and then 3 and 6 months later. The results obtained demonstrated that after the acute period of myocardial infarction there was no difference between the parameters under control. At the same time the results of dynamic monitoring confirmed that later on the patients felt some peculiarities during the left ventricle remodelling process. Three months later there was an increase of the left ventricle sphericity index during the systoly in the patients of group II. Six months later the patients of group II showed significant difference in five indices of remodelling versus the patients on thrombolitic therapy.
Organization of health care for the patients with benign diseases: the problem of one-day hospitalization
Authors: Kochorova L. V. , Okulov M. V. , Givyan B. L.
Published: December 2018

The article analises the volume of medical care to the citizens of St. Petersburg, suffering with benign diseases and hospitalized for one day. It is shown,that the level of one-day hospitalization is a marker of not approved hospitalization and unreasonable spending of funds in the state system of obligatory insurance.
Etiopathogenetic features of peptic ulcer in the young people depending on the hereditary predisposition
Authors: Kuramshina O. A. , Kryukova A. Ya. , Gabbasova L. V. , Kofanova Yu. A.
Published: December 2018

Etiopathogenetic ulcer is of particular interest because of its great role in hereditary predisposition to formation of this pathology. The authors detail not only the risk factors but the features of the neuro-psychic sphere, the clinical picture, and endoscopic features in their interrelation with genetic predisposition to the disease.
Clinical and pathogenetic variants of peptic ulcer
Authors: Kryukova A. Ya. , Kuramshina O. A.
Published: December 2018

The authors present some variants of the peptic ulcer course, with pathogenesis of the pathology being taken into account. Attention has been paid to the role of the central nervous system and of the vegetative nervous system as well as to psychosomatic mechanisms of the given pathology development.
Postpartum anaerobic wound infection
Authors: Korobkov N. A.
Published: December 2018

The objective of the study was to elucidate the role of nonclostridial anaerobic microflora in the pathogenesis of postpartum infectious and inflammatory diseases, and to choose an effective combination of antimicrobial chemotherapy. Inclusion of hyperbaric oxygen and of chemotherapy of the directed action on the obligate anaerobic flora contributed to rapid disappearance of the systemic inflammation signs and to proper involution of the uterus in 56 (86.2 %) parturients in the main group. Successful treatment in the control group was observed in 44 (67.7 %) patients (P=0.12).
Emotional deprivation and adaptation resources in male and female oncologic patients
Authors: Rousina N. A.
Published: December 2018

The paper deals with the investigation into gender adaptation resourses of the patients in an Oncologic Clinic. Attention was paid to similarities and differences in the mechanisms of psychological protection, of coping!reactions, of the patient`s attitude to the disease as well as to the basic emotional states in the male and female patients in order to facilitate the choice proper psychotherapeutic targets.
Extracellular domain of HER2 heterologous expression in bacteria
Authors: Dolgikh V. V. , Senderskiy, I. V. , Tetz G. V. , Tetz V. V.
Published: December 2018

Human epidermal growth factor receptor (HER2/neu, c ErbB2) is a protooncogene protein which is overexpressed in some oncological diseases including 30 % of breast cancers, tumors in the ovary, stomach and other organs of the human body as well. Since Her2tumor status testing is the essential part of successful cancer treatment, expression and purification of substantial amounts of the extracellular domain of the ECD HER2 is an important task. In this work sequence encoding HER2 extracellular domain was cloned and expressed in E.coli.
Psychosomatic disorders in children in pediatric hospital settings
Authors: Kalinina M. A. , Baz L. L.
Published: December 2018

The authors present the results of medical examination of the children who had been admitted to the pediatric hospital for suspected vegetovascular dystonia. The group 29 children at the age of 6-12 ys. careful examination revealed prevalence of psychopathological disorders in the range from prenosolgic forms to distinct psychic disorders. Partial symptoms of the post-remedial defect corresponding - in the period of examination - to the scheme of dysharmonical, mosaic development of a personality. Analysis of the anamnestic parameters revealed some aggravating factors - the factors of risk for development of psychosomatic pathology (hereditary, social deprivating, etc.). Polymorphism of the patients symptomatics (symptoms suggests complex investigation of the children including consultation of the psychiatrist.
Assessment of the scope of ambulatory medical aid for the patients with leiomyoma of the uterus provided in the system of obligatory insurance in St. Petersburg
Authors: Kochorova L. V. , Tsivyan B. L. , Okulov M. V.
Published: December 2018

The investigation was carried out at the bases of Hospital № 40 and of the Health Protection Department of I.P. Pavlov St. Petersburg State Medical University. The authors analyze the scope of the ambulatory medical aid for the patients with leiomyoma of the uterus provided in the system of obligatory medical insurance in St. Petersburg. The scope of the ambulatory aid for the mentioned patients significantly varies in different districts of the city - the fact to be taken into consideration.
Unfavourable factors promoting development of myopia among the students of medical colleges
Authors: Valiakhmetova I. M. , Akhmerova S. G. , Sagitov R. N.
Published: December 2018

To define the risk factors of myopia development among the students the authors got acquainted with spreading of the pathology among the students and their parents. 313 students of Tuimaizy medical college (at the age of 16 to 22 ys) and their parents (n = 579) participated in the study. Attention was paid to the internal factors (heredity, family atmosphere, quality of life) and to the external factors (the life, intensity in studying) -the factors promoting development of myopia. Special psychomedico-pedagogical commission has been organized for better health protection of the organ of vision in teenagers in Tuimaizy medical college.
Special features of Foix-Alajouanine syndrome (clinical course)
Authors: Lu Z. . , Shuleshova N. V. , Skoromets A. A.
Published: December 2018

The aim of the work is to improve the diagnostics of spinal AVMs. For the proper diagnosis of Foix-Alajouanine syndrome the speed of progression and the dynamics of the spinal focal neurological signs, as well as the volume of the spinal lesion should be taken into account. Evaluation of the results of additional methods of investigation: spinal MRI, spinal MR angiography, MR-tractography, etc. is also needed. Selective spinal angiography remains the optimal diagnostic method for spinal AVMs. The treatment must include anticoagulants and surgery.
Clinical indications and methods of application of modified crowned cutters in surgical treatment of the patients with severe craniocerebral trauma
Authors: Koksharev I. V.
Published: December 2018

The aim of the research was to improve the results of treatment of severe craniocerebral traumas by development of the scientifically based technology of surgical management of various intracranial hematomas using modified crowned cutters of different diameters. Comparative analysis of the surgical treatment of the patients with craniocerebral injuries in the main group and in the control one showed clinical and practical efficiency of the modified structures of the crowned cutters in the surgical treatment versus the traditional cutters - 50 % shorter time of the bone stage craniotomy in the main group, 4.3 % lowered blood loss, and 14.7 % shorter period of hospitalization.
Features of psychosomatic status and its relationship with magnesium, blood lipid levels and complications of hypertension
Authors: Usenko G. A. , Usenko A. G. , Mashkov S. V. , Petukhov D. A. , Vasendin D. V.
Published: December 2018

In contrast to the empirical anti-hypertensive therapy, the targeted antihypertensive therapy was combined with the earlier (6 months) and more pronounced approach of the lipid content of blood and magnesium to those in healthy individuals of appropriate temperament and anxiety; lower was the proportion of people with the areterial hypertension complications.
Features of metabolic disorders in the patients with diseases associated with atherosclerosis, on the background of functional bile outflow abnormalities
Authors: Gorbacheva I. A. , Sycheva Yu. A. , Shabak-Spassky P. S. , Nikolaeva L. A. , Vladimirova L. G.
Published: December 2018

The paper presents the results of evaluation of the pathogenetic relationship between atherosclerosis and functional abnormalities of the bile outflow. The main group included 54 patients with cardiovascular pathology and biliary dyskinesia. The group of comparison consisted of 20 patients with chronic coronary artery disease. The results suggest that the functional bile outflow abnormality is a risk factor of atherosclerosis progression leading to hypercholesterolemia and dyslipidemia, and should be considered in the development of integrated approaches to prevention and treatment of the diseases caused by atherosclerosis.
Fluorescent diagnosis of acnes
Authors: Romanova O. L.
Published: December 2018

The porphyrins produced by Propionibacterium acnes exhibit an orange-red fluorescence under UVA light. Our experience with treatment of 20 patients with different forms of ames has shown effectiveness of the external antibacterial therapy with the aid of the fluorescent photography of the skin.
Atopic dermatitis severity in the patients with hepatobilliary pathology
Authors: Melnikova T. V.
Published: December 2018

The aim of the research was to define severity of atopic dermatitis (AtD) in the patients with hepatobiliary pathology. 221 patients with AtD were under investigation. 51 of them had associated biliary dyskinesia, 45 patients had chronic viral hepatitis (CVH) without replecative kinesis, 65 patients had chronic viral hepatitis (CVH) with replecative kinesis, and 50 patients had no hepatobiliary pathology. The results obtained showed marked effect of the hepato-biliary system pathology on the severity of the AtD pathology. The patients with biliary dyskinesia have a lichenoid kind of AtD and patients with deep-rooted viral hepatitis have an eczematous kind of AtD.
Modern approach in the therapy of Alzheimer's disease
Authors: Rodin D. I. , Schvarzman A. L. , Saranzeva S. V.
Published: December 2018

Alzheimer's disease is a well-known neurodegenerative disorder. One of its main risk factors is age. Due to a worldwide increase of human longevity Alzheimer's disease became the most common form of dementia. The disease has been studied in different countries for many decades but still its etiology remains unclear. By now there is no cure for Alzheimer's, moreover there are no that can at least slow down the disease progression. In this review we made an attempt to summarize all current studies of the most advanced drugs for Alzheimer's.
The effect of COMT gene on the target precision of the athlete movement
Authors: Mikhailova E. V. , Lyphanov A. D. , Rakhmatulina L. Sh. , Phinogenova L. A. , Demenev S. V. , Khadyeva M. N.
Published: December 2018

The aim of the study was to find correlation between COMT gene alleles and the target precision of the athlete movement. 68 Russian competing athletes involved in boxing and volleyball, participated in the study. We found interrelation between COMT Met allele and a tall stature in the volleyball players.
Various surgical techniques for the treatment of inflammatory diseases of the periodontium
Authors: Ulitovskiy S. B. , Galibin O. V. , Tomson V. V. , Antipova A. V. , Vilesov A. D. , Suslov D. N. , Ukina G. U. , Yudin V. E. , Dobrovolskaya I. P. , Popryadukhin P. V.
Published: December 2018

The inflammatory periodontal diseases (IPD) take the second place after caries of teeth therefore the questions of treatment and prevention of IPD are especially actual. In the IPD treatment are the most effective, it is possible to allocate the surgical methods. In the present article questions of improvement of traditional techniques of surgical treatment, and also development and deployment of the new are considered.
Evaluation of the level of the competence development in the field of disease prevention and healthy lifestyle among medical students
Authors: Sivas N. V.
Published: December 2018

The principles of competent approach in the teaching of the medical university students in the disease prevention and healthy lifestyle are given in the article. For the formation of competence in the disease prevention and healthy lifestyles the pedagogical integral technology is used, developed by integrating content and disciplines of the medical education and Physical Culture. Further formation of competences in the preventive medicine and healthy lifestyle is being accomplished through the project method of teaching based on active projects. Advantages of the assessment of the competence of the medical university students in disease prevention and healthy lifestyle in the form of an authentic representational portfolio are given in the article. Modern assessment activity in education is focused on personal achievements of students, which may be reflected in different versions of portfolio. Authentic assessment is the most convenient and reliable in the case of the competence assessment, since it focuses primarily on the practical results of activity takes into account and promotes initiative, personal potential of the student, provides an opportunity to see the results and to obtain an assessment of achievements, allows not only to generate individual educational trajectory, but also to monitor the level of development of the educational content. The article reveals the content of the authentic representational portfolio and provides recommendations on its design and evaluation.
Psychological maintenance as an integrated approach to prevention and correction of professional burning out of the medical staff
Authors: Kucher V. S. , Vodopyanova N. E.
Published: December 2018

The syndrome of professional burning out is a complex of symptoms and signs evidenced in various negative psychic conditions at individual, interpersonal and organizational levels. It is formed owing to a long mismatch between the requirements of the professional environment and the resources of the expert. Analysis of the preventive and correctional programs as a psychological assistance showed insufficiency of such approach. Creation of preventive and correctional programs within psychological maintenance from the position of involution of professional resources, taking into account the theoretical - methodological basis (the concept, the purposes, tasks, system approach, criteria of efficiency) and the subjective-personal resources of counteraction directed at activization to burning out at all stages of professional development is progressive.
Financial expenditures for rendering home medical and social care to lonely and lonely-residing elderly people
Authors: Moroz I. N. , Svetlovich T. G. , Kalinina T. V.
Published: December 2018

Financial resources for rendering home medical and social care were split between the health care institutions (67.4 %), the territorial centers of social care (32.1 %) and the Visiting Nurses Service of BRCS with 0.5 % only.
Аlterationdegree of NMDA and AMPA receptors of glutamate in the pathogenesis of the disease and technological peculiarities of surgical treatment of the hemispheric glioma-swith the epileptic syndrome
Authors: Ochkolyas V. N. , Volov M. B.
Published: December 2018

The development of effective approaches to the treatment of patients with symptomatic tumor epilepsy was determined by the level of our fundamental knowledge of the basic mechanisms of epileptogenesis on cellular and molecular level. 92 patients with gliomas of the cerebral hemisphereswere examined. Immunoenzyme method ofsemiquantitative determination of the level of autoantibodies to NR2A subunit of NMDA and GluR1 subunit of AMPA receptors of glutamate was used. The reaction of NMDA and AMPA glutamate receptors depending on the availability of an epileptic syndrome in the clinical picture of the disease and the extent of radical surgery has been studied. Pre-emptive increase of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate in patients with hemispheric gliomaswith epileptic syndrome was demonstrated. It was foundonly the total removal of the tumor reduced significantly the level of autoantibodies to ionotropic glutamate receptors.
Correlation between clinical characteristics of mental disorders and associated cardiomyopathy
Authors: Kozlova S. N. , Krasnov A. A.
Published: December 2018

Two groups of patients with mental disorders in sections F2 according to ICD-10 (91 patients) and F4 (94 patients) were examined. The mean age of the patients was 36±7,6 years. A significantly higher percentage of secondary cardiomyopathy was in the patients with endogenous mental pathology - 51.2 % and in those with neurotic disorders - 37.7 % (pâ,01). It depended neither on the type and dynamics of the mental illness, but was more determined by its severityand in the case of endogenous mental illness - byits duration.
Articulate cartilage of humeral bone structure characteristics under high temperature
Authors: Laorukooa O. S. , Aleksina L. A.
Published: December 2018

Articulate cartilage of the humeral bone head structure characteristics according to the temperature data and prolongation of their action under high temperature (50 - 90 °С) are demonstrated on the basis of anatomy and histology studies. In female morphological changes occurred much earlier than in male due to less thickness of their articulate cartilage. The obtained findings of high temperature damage effects on the cartilage can be explained by cell protein denaturation in temperature rising even more than +45 °C. More frequent occurence of musculoskeletal system diseaes in metallurgists is explained by the results obtained.
Interrelation between the content of magnesium in the blood of the strain stenocardia patients of different temperament and anxiety and tension degree of the Earth magnetic field
Authors: Usenko G. A. , Usenko A. G. , Vasendin D. V. , Schakirova N. A.
Published: December 2018

During the magnetic storms magnesium content decreases and frequency of angina pectoris attacks increases minimally in the lowanxiety cholerics and maximally in the highanxiety melancholics and phlegmatics. The latter are the groups at risk of developing complications of coronary heart disease.
Sanation of carious and periapical foci in young athletes with impairment of cardiovascular adaptation
Authors: Belyaev I. I. , Hatskevich G. A.
Published: December 2018

The aim of this study was to evaluate the impact of sanation of oral cavity in young athletes on the course of adaptation of the cardiovascular system to the condition of sports activities. According to the research results, it was revealed that the optimal period for sanation of periapical odontogenic foci in athletes with clinical signs of impairment (dysfunction) of cardiovascular system adaptation to exercise stress was a preparatory training period, while carious lesion sanation required preparatory or postcompetition periods.
Asthenic-depressive frustrations as a factor of the adverse forecast of multifocal atherosclerosis of the patient, who transferred ARS I degree of severity
Authors: Metlyaeva N. A.
Published: December 2018

Features of development of all-somatic and psychosomatic pathology in B.A.I. are based on a combination of genetic prerequisites, environment influences (the stress caused by accident on the ChNPP) and social factors, influencing on him during a course of life, especially during early socialization. Thus at development of psychosomatic frustration the combination of feature of the mental reaction connected with the personal characteristic and special relationship between mental (stress) and physiological (somatic) by aspects of reaction which led to metabolism violation, to aging, decrease in adaptation opportunities of an organism and development age - dependent pathology took place.
Modification of the principles of the ventral wall alloplasty
Authors: Vasiliev S. V. , Moshkova T. A.
Published: December 2018

The experience in modification of the surgical methods in implantation and fixation of the prostheses was estimated in 152 patients. Application of the author's methods significantly reduces postoperative complications and prevents hernia relapses.
The role of protective-adaptive behavior in mechanisms of adaptation to the disease in patients with inflammatory bowel diseases
Authors: Fedorova V. L. , Baranovsky A. U. , Shukina O. B. , Petrov D. P. , Segal A. M.
Published: December 2018

Correlations of protective-adaptive behavior and the level of adaptation activity were determined in 48 men and 52 women with inflammatory bowel disease (IBD) and the necessity of this investigation from systemic positions of human adaptation was confirmed. Intercommunications of coping mechanisms and psychological protection ones with clinical characteristics of the disease were revealed. Distinct dominants in protective-adaptive behavior structure showing adaptation mechanisms tension in severe course of the disease and affective comorhidity with the tendency to the exhaustion of adaptive-compensatory resources were detected.
Features of remodeling of right heart chambers according to tissue Doppler and its correlation with cardiac rhythm disturbance in patients with COPD 2-3 severity
Authors: Zhuk O. A. , Perley V. E. , Gichkin A. Y. , Alexandrov A. L. , Titova O. N. , Kuzubova N. A. , Egorova N. V.
Published: December 2018

The article presents the study of early sings of dysfunction of right and left chambers of heart in patients with COPD 2 - 3 severity, correlation between structural and electrical remodeling of heart according to the stages of pulmonary hypertension. Standard tissue Doppler echocardiographic parameters and modes were used for the diagnosing. We examined 35 patients with COPD 2 - 3 severity; the control group consisted of 15 patients. The ECG Holter monitoring was made for all patients to identify cardiac rhythm disturbance and correlation with the COPD severity. Standard method of the ECG with modes of tissue Doppler (pulsed wave Tissue Doppler Imaging - PW TDI, color tissue Doppler imaging -TDI, tissue myocardial Doppler - TMD, tissue Tracking - TT, Doppler for evaluation of myocardial strain and myocardial strain rate) were made to identify the stage of dysfunction. The results of the study concluded that according to the TDI the dysfunction of right ventricle was more apparent in patients with COPD 3 severity. Pathological arrhythmias were significantly detected in group of patients with COPD 3 severity. In compliance with our observations, the reduce of rapid myocardial strain rates and its inverse proportion with the severity in accordance to the evaluation of longitudinal strain and rate of movement of fibrous ring in tricuspid valve were observed in patients with COPD. Thus the application of the TDI modes for evaluating of early signs of cardiac remodeling in patients with COPD and potential adequate jugulation for preventing chronic cor pulmonale is expedient.
Diurnal variations of mood markers
Authors: Volchek O. D. , Aleksina L. A.
Published: December 2018

Diurnal dynamics of necessity of socialized emotional experiences (SEE) was researched with the help of the B.I. Dodonov diagnostic checklist. The data for 514 women and 252 men were collecting from 1994 to 2013 years. The mean age of responders was 29,4 years. Significant and reliable changes in SEE markers were found in relation to diurnal variations and it was different for men and women. Analysis of findings for the periods of 1994-2006 and 2009-2013 confirmed the diurnal variations of SEE. Furthermore, SEE markers and their dynamics can undergo significant changes due to long-term variations. The adaptive function of motivation displays in it as a result of variability natural and social environment.
Analysis of terminological literacy of dental lexicon
Authors: Fejzrahmanova N. N. , Trezubov V. N.
Published: December 2018

The paper contains the quantitative analysis of contextual lexical literacy of 9 magazines and 3 illustrated newspapers (218 articles) on stomatology, 9 textbooks, 28 manuals for higher education institutions, 148 theses from the collections of scientific works. Besides, 126 headings of articles and 57 reports, lectures, seminars are analyzed. Calculations of relative and absolute measures were carried out by the formulas offered by authors of the work. Thus the rather high percent of the errors in written and oral speech of dentists was revealed in all tested editions. On the basis of the received results the authors drew the conclusion of the necessary inclusion of lexical and terminological courses in educational process and creation of active forms of standard highly specialized dictionaries which need to be used as manuals in training process.
Prevalence of iodine deficiency disorders and effectiveness of iodine prophylaxis among the population of reproductive age living in Saint Petersburg
Authors: Soboleva D. E. , Dora S. V. , Volkova A. R. , Ter-Oganesyants E. A.
Published: December 2018

The purpose of the study is the assessment of iodine status and effectiveness of iodine prophylaxis among the population of reproductive age. In this regard, we examined 200 individuals from 18 up to 44 years old living in Saint Petersburg for more than 3 years permanently. Most of the examined individuals had mild iodine deficiency, less than half of people of reproductive age (46 %) used iodized salt at home. Goiter was found by palpation in 8 % of participants. More than half of the surveyed individuals are women of reproductive age who are at risk for the development of iodine deficiency disorders. Our data reflect an unfavorable situation in fight against iodine deficiency disorders in Saint Petersburg. Probably, the voluntary model of using iodized salt as the prevention of iodine deficiency in the Russian Federation is not effective enough.
Noninvasive diagnostics for colorectal cancer: molecular genetic fecal DNA analysis
Authors: Butrovich G. M. , Mirlina E. D. , Habarova I. G. , Vostrukhina O. A.
Published: December 2018

Colorectal cancer (CRC) is still one of the leading causes of cancer-related death all over the world. An early diagnosis is fundamental thing for reducing the CRC-related morbidity and mortality. Nowadays researchers are studying more reliable and effective non-invasive screening tests, using easily available biological samples, such as feces. Such methods have high potential to collect and deliver samples. The comparison of some new variants genomic fecal DNA analysis and traditional fecal occult blood tests are discussed in this review. Sensitivity, specificity of the methods, processability, efficacy and ability of early CRC screening are the criteria for the preference of the using of one of these methods. These factors give the opportunity to carry out the large-scale CRC screening. This technological advance promises to increase the efficiency of the fecal DNA analysis and put the using of new clinical applications.
Social contacts of lonely seniors and seniors living alone as a resource for organization of health and social care
Authors: Moroz I. N. , Svetlovich T. G.
Published: December 2018

Social contacts of 623 lonely and living alone 60-and- older seniors were studied. A considerable part of respondents indicated the existence of social contacts with relatives (71.9 %) and neighbors, friends, acquaintances (94.2 %). The majority of respondents preferred health and social care though only 69.5 % of respondents could rely on relatives (67.7 % of lonely seniors and 71.4 % living alone seniors).
The condition of homeostatic equilibrium in patients with newly diagnosed pulmonary tuberculosis before treatment
Authors: Brazhenko N. A. , Brazhenko O. N. , Brazhenko A. I. , Chuikova A. G. , Mikcheeva E. N.
Published: December 2018

The conducted studies indicate that before the beginning of antituberculous treatment TB patients with homeostatic equilibrium disorder depending on the phase state of the specific process in the lungs, the expression of the intoxication syndrome, the extent of lung tissue damage and the age of the patients. Increasing of BHE(body homeostatic equilibrium) disfunction rate is followed by upraise of defective adaptive reactions. LLI indicators intend for BHE evaluation, H and R of the formed elements of the white bloodcellsintend to state the degree of BHE disfunction.
Condition of vestibular function in patients with Meniere's disease for the early term after treatment
Authors: Shevchenko T. A.
Published: December 2018

The efficiency rating of the treatment in patients with Meniere's disease was performed with the help of different methods in accordance to vestibular function for the early term (in 3 months) after treatment. Improvement of clinical course was observed in all groups of patients. However. complex therapy became the most effective method which included pneumomassage of labyrinthine windows and kinesitherapy. The article shows advantages of complex therapy over the medication therapy according to assessment of vestibular dysfunction.
Correlationbetween the activity of lipoprotein-associated phospholipase A2 and blood lipid levels in hypertensive patients with different temperament and anxiety
Authors: Usenko G. A. , Vasendin B. V. , Usenko A. G.
Published: December 2018

It was revealed that melancholic and phlegmatic had the lowest content of high-density lipoprotein and the highest content atherogenic lipid fractions combined with maximum activity and weight of lipoprotein-associated phospholipase A2 as well as the highest quantity of people with complications of hypertension among the examined patients. The ratio of people with complications in groups of choleric and sanguine with high level of anxiety and phlegmatic and melancholic with high level of anxiety was 1: 2.
In regard to the question of macroscopic differential diagnosis of alcoholic and dilated cardiomyopathy
Authors: Sokolova O. V. , Petrova J. A.
Published: December 2018

The differential diagnosis of alcoholic and dilated cardiomyopathy according to the macroscopic data is represented in the article. The identity of macroscopic changes of heart, related to alcoholic and dilated cardiomyopathy, cannot diagnose these diseases based on the macroscopic characteristics; especially if there are no other visceral manifestations typical for chronic alcoholism.
Opinion of medical staff about conditions and level of organization of work at the ambulance hospital departments
Authors: Kochorooa L. V. , Elohin V. V.
Published: December 2018

The article presents some results of an in-depth sociological study of doctors and nurses in the emergency hospital. In the research process the opinion about peculiarities of the organization of work at the ambulance hospital department was studied, Kaliningrad.
Review of patients' opinions of quality of inpatient care at the cardiac units offering different care and treatment intensity
Authors: Vishnyakov N. I. , Gusev A. O. , Makańdze A. O. , Dodonova I. V.
Published: December 2018

The article presents the analysis of the results of sociological studies of the patients admitted to cardiac unit for patients with myocardial infarction and to the Department of medical rehabilitation for such patients. We studied the influence of ethical aspects of conduct of the medical staff, and household conditions in the offices on the level of patients' satisfaction with quality of medical care.
Ways to improve the results of conservative surgery in breast cancer patients
Authors: Lalak I. A.
Published: December 2018

The purpose of this study was to investigate risk factors for locally-regional recurrence of breast cancer after conservative surgery.
Features of immune status in athletes specializing in rowing and handball
Authors: Vasilenko V. S. , Mamiev N. D.
Published: December 2018

The work is perfromed at the department of the hospital therapy GPMU, laboratory of llergiology and immunology of the research-practical Center of Dental faculty of SpbGMU named after I. Р. Pavlov. State of cellular and humoral immunity at the beginning and at the end of the training year of 15-17 years old young sportsmen of the first level and candidates masters of sports involved in an academic rowing and handball was studied. The athletes of both groups showed significant improvements as compared to the persons not involved in sports, lymphocyte apoptosis inducers (CD95+), the natural killer cells (CD16 + ) and B-lymphocytes (CD20 + ). Over time, in the athletes, regardless the sport, unidirectional changes are detected, encompassing the enhancing of the relative number of CD25+ with receptors for IL2, and immunoglobulin levels.
Analysis of pharmacoepidemiologal indicators of consumption of opiates and opioids in St. Petersburg: trends in the early XXI century
Authors: Pchelintsev M. V.
Published: December 2018

The article presents the author's self-retrieved data on study of pharmacoepidemiological indicators of consumption of opiates and opioids in St. Petersburg from 2001 to 2013. Pharmaco-epidemiological indicators of consumption of opioids in St. Petersburg and a number of countries are compared. Based on these estimates, the author suggests the ways to optimize provision of patients suffering intense acute and chronic pain with opiates and opioids.
Professional and personality tolerance exemplified by medical workers
Authors: Makarov Yu. A.
Published: December 2018

The article in question runs about the concept of professional tolerance, how to generate it, and under which conditions.
Structural changes in the thymus in the anabolic phase after exposure to experimental hyperthermia
Authors: Vasendin D. V. , Michurina S. V. , Ishchenko I. Yu.
Published: December 2018

In the anabolic phase of postoperational period, restoration of the structure of the blood-thymic thymus barrier, reduced edema of perivascular and interstitial spaces in in the thymus barrier, and emergence of a large number of epithelial cells with signs of unmodified structural organization are observed, indicating weakening of the destructive processes and increasing drainage of interstitial spaces in the body.
Modemmethodsofcomputerdiagnosticsdentalocclusionand TMJ, craniomandibular system and facial aesthetics
Authors: Yanushevich O. O. , Arutyunov S. D. , Antonik M. M.
Published: December 2018

To date, the traditional methods of instrumental diagnosis of occlusion and TMJ - quite time consuming and difficult to perform.Requires a very high qualification of experts capable of conducting such a diagnosis. In this regard, the existing and evolving digital technologycan not only producevarious removable and nonremovableorthodonticand orthopedicdesign, but also allow for a precise and easier to perform, diagnoseocclusion of dentition with the biomechanicsof the temporomandibular joint and the aesthetics of the patient's face.
Polymorphism of S19W of apolipoprotein A5gene in patients with type 2 diabetes mellitus - connection with metabolic parameters and triglyceride levels
Authors: Skoryukova S. A. , Kim M. V. , Bystrova A. A. , Babenko A. Yu. , Baranova E. I. , Pchelina S. N.
Published: December 2018

The article deals with genetic aspects of the influence of S19W polymorphic variants of apolipoprotein A5 gene, on the blood lipids in patients with type 2 diabetes mellitus, as well as influence of various clinical and anamnestic parameters on the blood lipids determining the development f atherogenic dyslipidemia.. The study revealed interrelation between 19W allele and hypertriglyceridemia development in patients with type 2 diabetes mellitus.
Opportunity of objective account of the colorimetric procedure using benzidine indicative at establishing the preliminary presence of blood on the material evidences
Authors: Konovalenko A. V. , Sidorov V. L. , Yagmurov O. D.
Published: December 2018

The article presents a modification of the colorimetric method for the preliminary establishment of presence of blood in the stainson the material evidences using benzidine test. The proposed modification is accompanied by photometric accounting and computer processing of the results. Performance, objectivity, as well as other features and advantages of this method when used in forensic practice are described in detail.
Advantages of application of colorimetric express methods to establish the presence of saliva in stains, traces and sites on the material evidences
Authors: Sidorov V. L. , Yagmuroo O. D. , Konooalenko A. V.
Published: December 2018

Проведен анализ опыта как отечественных, так и зарубежных авторов по применению методик установления наличия слюны на вещественных доказательств. Представлены две колориметрические модификации методик, предназначенных для ориентировочного установления наличия слюны в пятнах, следах и участках на вещественных доказательствах. Предложенная нами модификация сопровождается фотометрическим учетом и компьютерной обработкой результатов. Широко раскрываются производительность, объективность, а также другие возможности и преимущества данных методов при использовании их в судебно-медицинской практике.
Drug-induced toxicodermia as implication of a drug disease
Authors: Romanova O. L.
Published: December 2018

Toxicodermia belongs to the widespread and serious types of adverse reactions to medicines, affects doctors of all specialties and medical institutions of any profile. The risk of development of a toxicodermia for the majority of medicinal preparations makes 20% of all medicinal complications.
Dynamics and forecast of morbidity and mortality from prostate cancer in St. Petersburg
Authors: Petrova N. G. , Krotov K. Yu. , Vcherashniy D. B.
Published: December 2018

The paper presents the characteristics of primary disease incidence, prevalence and mortality from prostate cancer among men's population of St. Petersburg (normal and age-standardized rates); analyzed their dynamics for 20 years; shows the calculated trend of these indicators up to 2020.
Hemorrhoids and pregnancy: modern ideas of treatment and prevention
Authors: Vasiliev S. V. , Popov D. Y. , Nedozimovannyi A. I. , Sokolova O. S.
Published: December 2018

This article discusses issues related to the etiology, pathogenesis, clinical, prevention and treatment of hemorrhoids in pregnant and postpartum women. The evaluation of the need for and effectiveness of preventive treatment of exacerbations of hemorrhoids during pregnancy and the early postpartum period, pre-development of optimal efficiency and safety of treatments for hemorrhoids exacerbations during pregnancy. Applications submitted treatments and prevention can significantly reduce the risk of acute hemorrhoids and reduce terms of relief of symptoms in pregnant and postpartum women.
Options for the formation of the psychosomatic spectrum disorders
Authors: Krasnov Д. Д.
Published: December 2018

On the ground of longstanding research (1986-2012) of mental and somatic health of service personnel and draft age personnel, belonging to different age groups, three variants of psychosomatic relations formation were determined in the examined people: dysontogenetic, psychoorganic and disadaptive. Each option defined both particular way of psychosomatic status development and similar range of psychosomatic disorders.
Review of treatment modalities of malleolar fractures
Authors: Li Xinhao , Moskaliov V. P.
Published: December 2018

The frequency of malleolar fractures according to available literature data is about 40% of bone fractures, the majority of them are severe articular or compound fractures. The article covers the experience, accumulated by the generations of orthopedists concerning diagnostics, choice of efficient treatment, decrease of disability and improvement of patients' living standards.
The spectrum of malocclusions in patients with horizontal growth pattern
Authors: Fadeev R. A. , Galebskaya K. Y.
Published: December 2018

The spectrum of malocclusions in orthodontic patients with a horizontal growth pattern was under study. It was found, that in most cases horizontal type of facial growth was combined with malocclusion class II, which was caused by mandibular mycrognathia. Patients with horizontal growth pattern had mandibular protraction much more often, than patients of the control group. It was found that horizontal grows pattern was frequently accompanied by decreased value of an intermandibularangle, anterior position of mandible and maxilla, prominent chin, increased size of a mandibular ramus and decreased mandibular angle value.
Peculiarities of application of pulmonary rehabilitation program in patients with chronic obstructive pulmonary disease
Authors: Krylova Yu. G. , Trofimov V. I. , Potapchuk A. A.
Published: December 2018

Comprehensive pulmonary rehabilitation is gradually becoming the «gold standard» in the treatment of chronic obstructive pulmonary disease. It includes physical training, correction of nutritional status, patient education, psychological and social support.
Dental care needs in the child population of a megapolis
Authors: Ulitovskiy S. B. , Grigoriev V. A. , Volokitina E. V.
Published: December 2018

Based on the reports of examination preschool and school-aged children for the 2008-2014 year we can conclude that nowadays the issue of prevention of dental diseases among the inspected groups of children is actually
Treatment of refractory chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation with low-dose interleukin-2
Authors: Moiseev I. S. , Burmina E. A. , Tarakanova Y. A. , Zalyalov Y. R. , Smirnova A. G. , Pirogova O. V. , Bondarenko S. N. , Afanasyev B. V.
Published: December 2018

Refractory chronic graft-versus-host disease (cGVHD) is the complication of allogeneic hematopoietic stem cell transplantation (HCT) that signi ficantly impacts quality of life, may be associated with morbidity and mortality and has limited treatment options. 16 adult pts (median age 22, range 16 - 51 y.o.) with refractory cGVHD were enrolled. 6 pts were on steroids upon inclusion. 11 patients had severe (NIH) cGVHD, 6 - moderate, and have received 1-3 anti-cGVHD treatments before IL-2. Pts received IL-2 sc injections 1 MIU 3 times a week. Median duration of treatment was 2.5 moths (range 1 - 8 months). Partial clinical response was observed in 5 pts, complete response in 2 pts with overall response of 44 %. There was an improvement of Karnofsky in 25 % of pts, reduction in NIH severity scores in 37.5 % of and any objective response also in 44 % of pts. With median follow-up of 14 months overall survival was 62.5 %, non-relapse mortality was 12.5 % (2 pts), 25 % of patients had a relapse of underlying disease.
Social and physiological peculiarities and professional orientation of medical students
Authors: Toussova O. V. , Shaporov A. M. , Pavlova O. V. , Lebedeva G. G. , Isaeva E. R.
Published: December 2018

The article describes personality features, self-regulation patterns and professional orientation of medical students. It represents the results of the study conducted among the fourth year students. The sample is characterized with high enough behavior regulation, extraversion, high learning potential, flexible thinking, following intuition and personal opinion in profession choice. High anxiety as personality feature and stress vulnerability is typical for female students; independence tendency is typical for male students.