bluuebunny/crossref_metadata_2025 huggingface dataset:
Cybersports education in Ukraine: current state and
development prospects
Authors: Tsyhanovska Nataliia , Honchar Viacheslav , Danilyan Vadym , Piatysotska Svitlana
Published: April 2022

Мета: на підставі вивчення наукової літератури на інтернет-джерел проаналізувати сучасний стан кіберспортивної освіти в Україні та визначити перспективи її розвитку. Матеріал і методи: матеріалом дослідження є наукова література та інтернет-джерела, в яких висвітлюється актуальний стан кіберспорту та кіберспортивної освіти в Україні. Методи дослідження: аналіз, узагальнення та систематизація даних; історичний, логічний, проблемно-пошуковий, прогностичний. Результати: Кіберспорт являє собою перспективну спортивну та економічну галузь, в основі якої лежить використання комп’ютерних ігор. Водночас кіберспорт представляє собою новий соціокультурний феномен, що потребує осмислення філософів, культурологів, психологів та мистецтвознавців. Перевагою кіберспорту є можливість організації змагань у дистанційному режимі, що дозволяє задіяти більшу кількість глядачів. Останній факт робить кіберспорт досить привабливим для потенційних спонсорів та рекламодавців. Розвиток кіберспорту потребує залучення професійних кіберспортсменів із відповідно розвиненими когнітивними здібностями та психологічними якостями, а також інших фахівців, що забезпечують постійну та безперебійну організацію, проведення та висвітлення спортивних е-змагань на належному рівні (тренерів, психологів, менеджерів, фахівців із коучингу, брендингу, зв’язків із громадськістю, коментаторів, аналітиків, маркетологів, режисерів-постановників тощо). В університетах Європи, Америки, Азії освітні програми, спрямовані на отримання освіти в галузі кіберспорту досить різноманітні та представлені у достатній кількості. На відміну від закордонних закладів вищої освіти, вітчизняні ЗВО практично не пропонують освітніх програм, які відповідають потребам ринку кіберспорту. Тому кіберспортивна освіта в Україні є перспективним освітнім напрямом, що відповідатиме сучасним потребам ринку праці та запитам потенційних роботодавців. Висновки: Кіберспортивна освіта в Україні є перспективним освітнім напрямом, що відповідатиме сучасним потребам ринку праці та запитам потенційних роботодавців. Водночас вона потребує визначення реальних потреб ринку вітчизняного кіберспорту задля розробки та впровадження актуальних освітніх програм, спрямованих на підготовку фахівців зазначеної галузі. Отримана інформація дозволить розробити та запропонувати нові освітні програми, які дозволять українському кіберспорту посісти належне місце на світовій арені.
Control of physical and technical readiness of football players at the stage
of specialized basic training
Authors: Lebediev Serhii , Zhurid Sergey , Koval Svyatoslav , Shalenko Victor
Published: April 2022

Мета: визначити на початку підготовчого періоду вихідний рівень фізичної та технічної підготовленості футболістів 2006 р.н. різних дитячо-юнацьких команд м. Харкова. Матеріал і методи: дослідження проводилося в серпні 2021 року. Контингент обстежуваних - спортсмени у кількості 56 футболістів ДЮФК (дитячо-юнацький футбольний клуб) «Арсенал» м. Харкова та ДЮСШ (дитячо-юнацька спортивна школа) № 7 м. Харкова, вік яких становив у середньому 14,6 років. Були визначені технічні та фізичні показники, які характеризують рівень підготовленості футболістів до початку змагального сезону. У дослідженні були використані такі методи: аналіз науково-методичної літератури, педагогічне тестування, методи математичної статистики. Результати: у роботі встановлені статистично достовірні відмінності між технічними показниками: в тесті біг 30 м (з м’ячем) (р <0,05; t=2,18), вкидання м’яча з-за бічної лінії (р<0,05; 2,88); у показниках з фізичної підготовленості статистично достовірні зміни були виявлені у тестах «Іллінойс» (р <0,05; t=2,72), човниковий біг 7х30 м (р<0,05; t=2,48), при цьому гравці ДЮФК «Арсенал» долають відстань швидше (р<0,05; t1=2,10; t2=2,05; t3=2,06; t7=2,15) на першому, другому, третьому та сьомому відрізках ніж гравці ДЮСШ № 7. У тесті на витривалість човниковий біг 5х30 м гравці ДЮФК «Арсенал» швидше (р<0,05; t=2,12) пробігають, ніж гравці ДЮСШ № 7, при цьому на першому та третьому відрізках гравці ДЮСШ № 7 повільніше (р<0,05; t1=2,75; t3=2,05) долають відстань, ніж футболісти ДЮФК «Арсенал». Висновки: аналіз спеціальної літератури свідчить, що сучасна науково-методична база в аналізі технічної та фізичної підготовленості у футболі є недостатньо вивченою для того, щоб забезпечити ефективну підготовку юнаків до вищих спортивних досягнень. У результаті дослідження встановлено статистично достовірні відмінності у показниках з фізичної та технічної підготовленості між ДЮФК «Арсенал» та ДЮСШ № 7 м. Харкова. Визначено, що футболісти 2006 року народження мають низький рівень функціональної працездатності.
Prevalence of peripheral blood natural killer cells ≥12% in women with recurrent pregnancy loss: study carried out in a private clinic of Mexico City
Authors: Víctor Manuel Vargas Hernández , Estuardo Luján-Irastorza Jesús , Carlos Durand-Montaño , Roberto Hernández-Ramos , Jesús Ávila-Pérez Felipe de , Daniela Ávila-Rebollar , Teresita de Jesús Valdez-Chávez , Antonio Yáñez-González Marco , Valeria García-Cruz , Giovani Pacheco-Pineda Josué
Published: April 2022

Objective: To report the prevalence of pNK≥12% and its relationship with RPL in a population of Mexican women. Methods: Retrospective, cross sectional and observational study which included 98 women with history of RPL, who were subjected to a blood test sample to measure pNK cell and prevent complications in further pregnancies. Two groups were formed: 1) CONTROL and 2) RPL: Women with history of 2 or more miscarriages. Results: Women in the RPL group were older and had higher BMI compared to the Control group. Prevalence of patient whit pNK≥12% increase in the RPL vs Control. RPL group showed a significant increase of pNK≥1% compared to the Control (11.3±0.5 vs 9.5±0.6%, p=0.002). Finally, the median level of pNK≥12% in the PRL group was higher than Control (15.1±0.5 vs 13.5±0.8%). Conclusion: RPL may be the result of increased pNK concentrations and as observed in this study, slightly more than 50% of the Mexican population could be susceptible to abortions.
Pediatric Medical Device Development and Regulation: Current State, Barriers, and Opportunities
Authors: Espinoza Juan , Shah Payal , Nagendra Gautam , Bar-Cohen Yaniv , Richmond Frances
Published: April 2022

Few medical devices are designed and marketed specifically for children. Instead, adult devices are often repurposed and used off-label in pediatrics. The innovation gap between pediatric and adult devices is complex and multifactorial. This review aims to summarize the medical device landscape, describe barriers to pediatric device development, and provide an update on current strategies to help overcome these limitations. Medical devices are regulated by the Food and Drug Administration. They are registered, cleared, or approved on the basis of a 3-tier risk classification system and a differentiated set of regulatory pathways. This includes some for products that receive special designations on the basis of specific aspects that warrant more rapid review and approval. Pediatric devices number only one-quarter of those developed for adults for multiple reasons. Clinically, innovators must adjust their products to address the smaller sizes, growth, and longer duration of use in children. Smaller sample sizes and population heterogeneity also challenge the ability to obtain sufficient safety data for regulatory submissions. Financial concerns stem from lower pediatric reimbursement rates coupled with a lack of nationally standardized coverage. There are a number of promising initiatives, including the Pediatric Device Consortia Program, Early Feasibility Studies, and the new System of Hospitals for Innovation in Pediatrics – Medical Devices. However, the gap will likely not be narrowed without broad cooperation across stakeholders from industry, academia, patient advocacy groups, health care providers, investors, payors, regulators, and Congress.
NATIONAL FOOD SECURITY: STATUS, PROBLEMS AND PERSPECTIVES
Authors: Ruscheva D. , Grozdanova S.
Published: April 2022

The production of food products in agriculture and the food industry in Bulgaria is important for the formation of the country's food resources, on which the national food security largely depends. The situation and challenges in providing the population with food are related to the stability of national sources for the availability of basic food products. In this regard, the report uses approaches to assess the situation, identifies problems and provides guidelines for the development of food production in the context of Bulgaria's membership in the European Union. Critical moments have been outlined and problems have been identified in providing the population with basic foodstuffs, where the reliability of domestic sources has a pronounced negative effect on the degree of food independence of the country, which as part of food security is part of national security.
STUDY OF COMPLIANCE WITH THE RULES FOR PREVENTION OF INFECTIONS RELATED TO DENTAL CARE AMONG DENTAL STUDENTS DURING A PANDEMIC OF SARS-2-COV / COVID-19
Authors: Stoeva V. , Bozhkova T. , Atanasovski A. , Kondeva V.
Published: April 2022

Introduction: In a SARS-CoV-2 / Covid-19 pandemic, it is important to know, assess and control the risk of transmitting this infection. The dental office is a risky place for the spread of this virus - conditions are created for multiple transmission of the virus.
Objective: To monitor compliance with anti-epidemic measures among dental students during a pandemic of SARS-CoV-2 / Covid -19.
Material and methods: Observation September 2020-May 2021. 50 fourth- and fifth-year FDM - Plovdiv were observed during their clinical exercises in prosthetic dentistry.
Results: 100% disinfect your hands, but in 30 seconds, 48%. In just 2 minutes, only 36% decontaminate the workplace. 32% disinfect the correctly taken prints, and in the case of finished constructions -17%.
Conclusion: The SARS-CoV-2 / Covid-19 pandemic has had a positive effect on anti-epidemic compliance. We recommend the preparation of an optimized work protocol.
The Catholic Church in the Czech Republic and Sexual Abuse of Minors
Authors: Vintrová Martina
Published: April 2022

The article describes the present the situation in the Church in the Czech Republic in relation to the topic of sexual abuse of minors in terms of extension of cases, education in the topic, church documents and measures adopted and prayer initiatives. It also discusses the specific factors that make it difficult to accept the reality of the existence of sexual abuse of minors by clerics also in the Catholic Church in the territory of the Czech Bishops Conference.
Crisis Communication in the Context of Child and Youth Protection – Diagnosis, Problems, Challenges. The Case of the Catholic Church in Poland
Authors: Przybysz Monika , Kloch Józef
Published: April 2022

Crisis management principles that have been in place and proven for decades by commercial companies and corporations, tested at great expense, apply equally to all non-commercial entities, governmental, religious, political, as well as to individuals. There is no deviation from them, as crises in today’s world are determined by the media, not the entity or institution itself. Every crisis can become an opportunity for change, strengthening, improvement, purification and even victory. The condition is a professional approach to the problem. A crisis can also be the beginning of the end, a failure. The biggest enemy of success in this situation is lack of knowledge how to act properly, mistakes in communication and management of resources. However, avoiding responsibility, hiding facts, manipulating information, being too quick and inconsiderate, resorting to falsehood, hypocrisy, and calculated behaviour will not facilitate success either. The article will analyse the institutional actions of the Catholic Church in Poland for the protection of children and adolescents in the context of the classical principles of crisis management applied in a crisis.
Violation of the Obligation of Residence According to the 1983 Code of Canon Law
Authors: Romanko Agnieszka
Published: April 2022

The obligation of residence is the obligation to reside in a specific territory on a permanent basis in connection with holding an ecclesiastical office. The delict of violation of the obligation of residence is penalized under can. 1396 of the 1983 Code of Canon Law and is strictly linked to the entrusted ecclesiastical office such as: cardinals holding specific offices in the Roman Curia, diocesan bishop, coadjutor bishop, auxiliary bishop, diocesan administrator, pastor, parochial administrator and a group of clerics administering the parish in solidum, parochial vicar. Violation of the obligation of residence is subject to a mandatory penalty. The gravest penalty provided for by the ecclesiastical legislator is the privation of ecclesiastical office.
Q-Methodology to Identify perceptions of deceased organ donation in the UK
Authors: Muaid R. M. , Chesney T.
Published: April 2022

Background. Attitude towards organ donation is predominantly positive in the UK, however, donation rate remains low. To develop more effective interventions, this research aims to examine the behavioural barriers in organ donations using Q methodology to elicit patterns of overlap among different barriers and motivators.

Method. A Q methodology study was conducted with 40 participants aged 19–64 were asked to rank 47 statements on issues that are associated with organ donation. By-person factor analysis using Centroid method and Varimax rotation was conducted to bring out patterns in the way statements were ranked to obtain groupings of participants who had arranged the statements in similar fashion.

Results. Four viewpoints were extracted: The Realist, the Optimist Hesitant, the Pessimist Determinant and the Empathetic. Salient barriers to organ donation presented in each viewpoint suggest that perceived lack of knowledge, anxiety, mistrust in the healthcare system and lack of cue to action are the main barriers to organ donation. Consensus statements suggest that religion and family agreement are inconsequential if attitude to organ donation is well formed.

Conclusion. There are different attitudes around deceased organ donation that were uncovered using Q methodology. These results suggest that people respond to behavioural change campaigns differently depending in their own perceptions on organ donation. We argue that a paradigm shift in behavioural interventions is underpinned by understanding the overlapping yet distinctive nature perceived perspectives.
Development of approaches to enzyme-free isolation of pancreatic islets
Authors: Skaletskaya G. N. , Skaletskiy N. N. , Bubentsova G. N. , Sevastianov V. I.
Published: April 2022

The success of pancreatic islet allotransplantation in the treatment of patients with a difficult-to-manage type 1 diabetes depends mainly on the quantity and quality of islets isolated from the pancreas of deceased donors using enzyme preparations, primarily collagenase. Numerous studies on improvement and standardization of islet isolation techniques have reached their limits in the last decade. This has made it impossible to further boost the number and quality of clinical transplants. Taking into account the negative impact of collagenase technique on the morphofunctional properties of isolated islets, this work has studied the possibility of enzyme-free isolation of islet tissue purified of exocrine ballast. Experiments using the pancreas of newborn and young rabbits showed that developing methodological approaches to obtaining islet-like cultures without the use of exogenous enzymes is feasible.
Induction of osteogenesis of the bone tissue Induction of osteogenesis in rabbit mandibular bone tissue using an albumin-based cryogenically structured porous 3D carrier loaded with a bioregulator
Authors: Shaikhaliev A. I. , Krasnov M. S. , Sidorsky E. V. , Yamskova V. P. , Lozinsky V. I.
Published: April 2022

Objective: to study the induction of osteogenesis caused by introducing into the defect area broadly porous cryogenically structured 3D carriers, based on serum albumin and loaded with a bioregulator isolated from bovine serum on an experimental model of mandible defect in rabbits in vivo.

Materials and methods. Cryogenically structured sponges in the form of cylindrical specimens, 5 mm in diameter and 5 mm in height, prepared from bovine serum albumin, were used as the bioregulator carrier. The experimental laboratory animals were male Chinchilla rabbits, weighing 2–2.5 kg. Bone tissue was skeletonized under anesthesia (intramuscular anesthetic Zoletil 100) with a 3-cm incision in the angle of the mandible and a 5-mm-diameter cutter was used to create a 2–3-mm deep defect to install an appropriate-size albumin sponge. A total of 24 animals participated in the experiment. X-ray control of the defect area was performed in vivo on day 14 using PanExam+ (Kavo) device (20 m X-ray). Histological examination of tissues was carried out at day 30 after the defect using a light microscope.

Results. Experiments performed indicate an active restoration of bone tissue in the extensive defect area when using an albumin-based 3D carrier with the inclusion of a bioregulator as compared to the control experiments. There were osteointegrative and osteoinductive processes, almost complete decomposition (biodegradation) of albumin sponge with formation of islands of dense bone tissue with small foci of coarse fibrous tissue in the defect. This demonstrated good dynamics of recovery processes at this stage of healing.

Conclusion. Under the action of a serum bioregulator contained in an albumin-based sponge, the repair process leads to restoration of normal bone tissue without formation of bone callus and altered bone tissue different from the native one.
Programmed cell death and liver diseases
Authors: Onishchenko N. A. , Gonikova Z. Z. , Nikolskaya A. O. , Kirsanova L. A. , Sevastianov V. I.
Published: April 2022

Cell death represents the most critical pathologic entity in liver disease, which dictates pathologic consequences such as inflammation, fibrosis, and cell transformation. We analyzed the conclusions of studies on the involvement of different types of programmed cell death (PCD) in the pathogenesis of liver diseases. Three main forms of PCD (autophagy, apoptosis, necrosis) and five additional, still insufficiently studied PCD – necroptosis, ferroptosis, pyroptosis, partanatosis and entosis – observed in the liver in various acute and chronic diseases are considered. The involvement of several PCD at once in the development of any one pathology and one type of PCD in different pathologies was established. This indicates the existence of cross-regulation of metabolism in the liver cells with different levels of damage in the formation of the main dominant type of PCD. Available results indicate the possibility of attenuation (correction) of functional and morphological manifestations of PCD in the organ by controlled blocking of effector-mediated PCD pathways, as well as targeted induction of autophagy, anti-apoptotic and anti-necrotic mechanisms in liver cells.
Structural valve degeneration: are there common mechanisms with atherosclerosis and calcific aortic stenosis?
Authors: Kostyunin A. E.
Published: April 2022

Current research shows that some of the pathogenetic processes behind structural destruction of bioprosthetic valves are largely similar to those involved in the development of atherosclerotic vascular lesions and native valve calcification. These processes include lipid and leukocyte infiltration, typical for both prosthetic and native tissues. They are accompanied by formation of foam cells, excessive production of matrix-degrading enzymes and increased oxidative stress. This fact suggests that some approaches to conservative treatment of atherosclerosis may be useful for prolonging the lifespan of bioprosthetic valves.
Assessment of the clinical status and behavioral risk factors in patients with cardiovascular and other noncommunicable diseases in Russia and neighboring countries during quarantine and self-isolation
Authors: Drapkina O. M. , Mamedov M. N. , Serpitis P. , Seisembekov T. Z. , Mekhtiyev S. Kh. , Murkamilov I. T. , Yarovaya E. B.
Published: April 2022

Aim. To carry out a comparative assessment of the clinical status and behavioral risk factors in patients with cardiovascular (CVD) and other noncommunicable diseases (NCDs) in Russia and neighboring countries during quarantine and selfisolation in the context of coronavirus disease 2019 (COVID-19) pandemic.

Material and methods. The study involved patients from Russia, Azerbaijan, Kazakhstan, Lithuania, Kyrgyzstan. A total of 351 men and women aged 30- 69 years with one or more NCDs were included, including hypertension (HTN), coronary artery disease with or without myocardial infarction, type 2 diabetes, chronic obstructive pulmonary disease/ asthma, and cancer that were in quarantine self-isolation. To assess the clinical status and risk factors, patients underwent a questionnaire and examination. The changes in health status was assessed using the EQ-5D questionnaire.

Results. During self-isolation and quarantine, 40% of patients noted a decrease and limitation of physical activity. An increase in food frequency and amount was registered in 35% of individuals. During quarantine, every third patient with HTN had hypertensive crises, and every fifth increased the doses of the drugs taken. In the examined cohort, exertional angina (30%) took second place among NCDs. In the group of Azerbaijan patients, every second had exertional angina, while in the Russian cohort — 33%, and in the Lithuanian group — every fourth patient. In general, health status deterioration among people with angina was noted in 6% of cases. In the examined group, type 2 diabetes was detected in 25% of cases. During quarantine, changes in hypoglycemic therapy were carried out in an average of 34% of patients. COVID-19 was registered in 22% of patients in the examined cohort. The largest number was found in the group from Kazakhstan — 57%, while the second place was taken by the Azerbaijan group — 40%. General condition deterioration was detected in 55% of cases in groups from Azerbaijan and Kazakhstan. In Russia, this was reported by 28,8% of patients, while in the group from Lithuania, every fourth patient noted a worsening of the health status. The lowest deterioration was registered in the Kyrgyzstan group (14%).

Conclusion. During quarantine and self-isolation among patients with NCDs, a decrease in physical activity, an increase in food consumption and smoking was noted. There was health status deterioration in patients with various NCDs, primarily with CVDs, which required therapy changes. Taken together, this was reflected in general condition worsening in patients with chronic NCDs. It is obvious that the development of comprehensive preventive measures in conditions of selfisolation and quarantine is required.
Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry
Authors: Lukyanov M. M. , Kutishenko N. P. , Martsevich S. Yu. , Pulin A. A. , Andreenko E. Yu. , Voronina V. P. , Dindikova V. A. , Dmitrieva N. A. , Lerman O. V. , Makoveeva A. N. , Okshina E. Yu. , Sgibneva A. S. , Smirnov A. A. , Belova E. N. , Klyashtorny V. G. , Kudryashov E. V. , Karpov O. E. , Drapkina O. M.
Published: April 2022

Aim. To assess long-term outcomes within 12 months after hospital treatment of patients with coronavirus disease 2019 (COVID-19) as part of a prospective registry.

Material and methods. Outcomes in the posthospital period were assessed in 827 patients diagnosed with COVID-19 (age, 58,0±14,8 years; men, 51,3%). For periods of 30-60 days, 6 and 12 months after discharge from the hospital, cases of death, nonfatal myocardial infarction (MI) and stroke, hospitalization, acute respiratory viral infections/influenza were assessed. The follow-up period was 13,0±1,5 months.

Results. During the follow-up period, 35 (4,2%) patients died, 6 (0,73%) and 4 (0,48%) cases of MI and stroke were registered. In addition, 142 (17%) patients were hospitalized, while 217 (26,2%) patients had acute respiratory viral infections/ influenza. Factors of age and length of intensive care unit stay were significantly associated (p<0,001) with the risk of all-cause death (hazard ratio (HR)=1,085 per 1 year of life and HR=6,98, respectively), with the risk of composite endpoint (death, non-fatal MI and stroke): HR=1,081 per 1 year of life and HP=4,47. Of the 35 deaths, 11 (31%) were within the first 30 days of follow-up, and 19 (54%) — 90 days after discharge from the hospital. A higher probability of hospitalization was associated with older age (odds ratio (OR)=1,038; p<0,001), while a higher probability of acute respiratory viral infections/influenza was associated with younger age (OR=0,976 per 1 year of life; p<0,001) and female sex (OR=1,414; p=0,03).

Conclusion. A prospective follow-up of 827 patients in the TARGET-VIP registry revealed that 12-month mortality was 4,2%, while more than half of the deaths (54%) were registered in the first 90 days, including 31% — for the first month after discharge from the hospital. The most common events were hospitalizations (17,0%) and acute respiratory viral infections/influenza (26,2%), while the rarest were myocardial infarction (0,73%) and stroke (0,48%). The key factors associated with 12-month mortality in the post-COVID-19 period were older age and intensive care unit stay during the reference hospitalization. A higher readmission rate during the follow-up period was associated with older age, and the prevalence of acute respiratory viral infections /influenza during the follow-up period was associated with younger patients and female sex.
Aspects of anticoagulant therapy in venous thromboembolism, pulmonary embolism. Focus on elderly patients
Authors: Romanova M. V. , Puzenko D. V.
Published: April 2022

The prevalence and mortality due to venous thromboembolism (VTE) occupies a leading position among the population throughout the world. The incidence and severity of VTE increases the older the patient. The emergence of a new group of direct oral anticoagulants significant changed the management of these groups of patients. The article touches upon the problem of choice, efficacy and safety of oral anticoagulants in elderly and senile patients with VTE, in particular in pulmonary embolism (PE). An analysis of randomized clinical trials and prospective cohort studies is given. In addition, rational recommendations are given on the optimal choice of oral anticoagulant in these categories of patients. Apixaban and rivaroxaban are highly effective drugs of choice with a reliable safety profile in patients of the senile age group in the prevention and treatment of VTE, including PE, and apixaban has the most optimal profile and safety class among all other oral anticoagulants when used in elderly and senile patients.
Risk factors for infiltration in children and adolescents with peripheral intravenous catheters
Authors: Santos Luciano Marques dos , Figueredo Irlane Batista , Silva Cleonara Sousa Gomes e , Catapano Uliana Oliveira , Silva Bianka Sousa Martins , Avelar Ariane Ferreira Machado
Published: April 2022

ABSTRACT Objectives: to estimate the incidence of infiltration and the factors associated with its occurrence in children and adolescents in the operative period and with peripheral intravenous catheters. Methods: a longitudinal and prospective study with children and adolescents using peripheral intravenous catheters, conducted at the surgical clinic unit of a pediatric hospital in Feira de Santana, State of Bahia, from April 2015 to December 2016. The study used Pearson’s chi-square and Fisher’s exact test for the analysis. It also applied multiple analyses using Poisson regression with robust variance. Results: the incidence of infiltration was 31.2% and was associated with female sex (RR=0.53; CI=[0.30-0.96]), non-eutrophic children (RR=2.27; CI=[1.25-4.20]), who used non-irritating and non-vesicant drugs (RR=1.72; CI=[1.03-2.87]), vesicant drugs (RR=1.84; CI=[1.05-3.22]) and irritating/vesicant electrolytes (RR=2.35; CI=[1.38-3.97]). Conclusions: the study suggests the development of strategies that will help in the prevention of this adverse event through the knowledge of the associated factors.
Professionals’ beliefs in patient involvement for hospital safety
Authors: Teixeira Cristiane Chagas , Bezerra Ana Lúcia Queiroz , Paranaguá Thatianny Tanferri de Brito , Afonso Thaisa Cristina
Published: April 2022

ABSTRACT Objectives: to analyze the beliefs of health care professionals about the benefits of patient involvement in care during hospitalization. Methods: a descriptive, exploratory, qualitative study was conducted with 87 health professionals from a teaching hospital. Semi-structured interviews were conducted between December 2019 and January 2020 - data was submitted to content analysis and interpreted in light of Rosenstock’s Model of Beliefs in Health. Results: participants included nursing technicians, nurses, doctors, and other professionals. The categories “Professionals’ beliefs about patient involvement in care”, “Practices of patient involvement in care” and “Factors favoring patient involvement in hospital care” emerged. The perception of professionals revealed the influence of patient involvement in care outcomes and benefits for the safety of care. Final Considerations: involving the patient in care is associated with the healthcare professional’s belief in the benefits of this practice for reducing incidents.
Longitudinal treatment of smoking in Primary Health Care: an evaluation research
Authors: Pires Graziele Adrieli Rodrigues , Charlo Patrícia Bossolani , Martins Marques Francielle Renata Danielli , Silva Ítalo Rodolfo , Radovanovic Cremilde Aparecida Trindade , Salci Maria Aparecida
Published: April 2022

ABSTRACT Objectives: to evaluate the coordination of the attention for continuing treatment for smoking cessation in the Primary Health Care, from the perspective of users. Methods: the conceptual base was longitudinal care, which is an attribute of the National Policy of Primary Care. The methodological framework was that of an evaluative research, as informed by theory-based evaluation. Data collection used observation with moderate participation in the groups to abandon smoking, intensive interviews with 22 users, and analysis of medical records. The interviews used initial and focused coding, which are analytical stages of the Grounded Theory, with the aid of the MaxQDA® software. Results: the interviewees had a positive evaluation of their treatment for smoking, although they mentioned limitations for medium- and long-term continuity. Final Considerations: the smoking treatment sessions, even if infrequent, were found to be a successful experience for smoking cessation.
Analysis of the temporal trend of mortality from sickle cell anemia in Brazil
Authors: Mota Felipe Machado , Ferreira Júnior Marcos Antonio , Cardoso Andréia Insabralde de Queiroz , Pompeo Carolina Mariana , Frota Oleci Pereira , Tsuha Daniel Henrique , Souza Albert Schiaveto de
Published: April 2022

ABSTRACT Objectives: To analyze the temporal trend of mortality from sickle cell anemia in Brazil, by region, in the period 1997-2017. Methods: epidemiological study, with an ecological design, with a temporal trend, carried out with data from the Mortality Information System. For descriptive analysis, absolute and relative frequencies were used. In the correlation analysis, the ANOVA test was used, followed by Tukey’s post-test. The temporal trend was obtained using the cubic polynomial regression test. Results: 6,813 deaths from sickle cell anemia were registered. Brown individuals (50.87%) were more frequent, with a predominance of males (50.4%), aged between 25 and 34 years and a higher incidence of deaths in the Midwest (0.25/100 thousand inhabitants). The time curve showed an increasing trend of deaths in the country between 1997 and 2015 (R2 = 0.98). Conclusions: sickle cell anemia showed increasing mortality in the 21 years analyzed and alerts health professionals and managers.
Evaluation of oscillometric blood pressure measurement devices available for online sale
Authors: Vigato Estefanie Siqueira , Souza Mariana Castro de , Dordetto Priscila Rangel , Lamas José Luiz Tatagiba
Published: April 2022

ABSTRACT Objectives: to characterize oscillometric blood pressure measurement devices for sale in the virtual market and identify which ones have undergone a validation study. Methods: this was a cross sectional study. The search for devices for sale was conducted on websites, and the sample was composed of 137 devices obtained from 644 ads. We conducted a bibliographic survey in five databases and web pages enlisting devices submitted for validation. The Kolmogorov-Smirnov test was used to check data distribution, followed by Mann-Whitney and Kruskal-Wallis tests for comparisons, using the SAS 9.4 program. Results: only 16.7% of the devices were validated. The home devices ranged from USD 10.57 to USD 275.67. Only 102 ads informed the cuff size, with different nomenclatures. Conclusions: most ads contained non-validated devices, which were cheaper. We identified some ads falsely informing validation.
Sobre as atividades de serviços: revendo conceitos e tipologias
Authors: KON ANITA
Published: April 2022

RESUMO Este artigo investiga alguns aspectos básicos sobre as definições e classificações tradicionalmente usadas das atividades de serviço. A primeira parte do artigo avalia algumas transformações essenciais das atividades de serviço, que estão ocorrendo nos processos produtivos, na natureza do produto, no consumo e no mercado, desde o avanço das recentes inovações tecnológicas. Ele enfatiza a dificuldade de medir e analisar essas recentes evoluções econômicas, usando as concepções tradicionais. A seguir, propõe uma revisão e atualização dos conceitos, a fim de adaptá-los ao novo papel desempenhado por esse setor no contexto produtivo mundial.
O Plano Real e a agricultura brasileira: perspectivas
Authors: MELO FERNANDO HOMEM DE
Published: April 2022

RESUMO Este artigo analisa os efeitos das políticas macroeconômicas do Plano Real na agricultura e discute as novas perspectivas abertas após a forte desvalorização de nossa moeda em janeiro de 1999. A agricultura brasileira foi severamente afetada pela combinação de altas taxas de juros - taxa de câmbio supervalorizada. Além disso, teve que enfrentar os problemas de redução excessiva das tarifas de importação, de importações financiadas e de baixas taxas de crescimento econômico nos últimos anos. Algumas mudanças favoráveis no comércio internacional compensaram, pelo menos parcialmente, o problema da supervalorização da moeda. O Brasil sempre foi reconhecido como tendo uma forte vantagem comparativa na agricultura. A desvalorização ocorrida, a partir de janeiro de 1999, abre melhores perspectivas para o país explorar sua competitividade nos mercados internacionais.
A political economy model of monetary policy: decentralized decision making and competition for seigniorage
Authors: HILLBRECHT RONALD
Published: April 2022

ABSTRACT A political economy model is developed to provide a rationale of monetary policy in high inflation regimes, such as the Brazilian experience until the advent of the Plano Real. Decision making of monetary policy is assumed to be decentralized, where several decision-makers competitively determine the quantity of money. It is shown that equilibrium inflation is higher than under the alternative monetary regime where decision making is centralized at the Central Bank. An important additional feature of this political economy model is that it does not rely on time-inconsistency to generate high and sub-optimal inflation.
The neo-Schumpeterian approach to innovation and Keynes’s probability: initial explorations
Authors: CROCCO MARCO
Published: April 2022

ABSTRACT The aim of the paper is to show that Keynes’s concept of probability can enrich the understanding of the process of the introduction of innovation offered by the Neo- Schumpeterian approach. To deal with uncertainty Neo-Schumpeterians introduce the concept of routines. What is suggested here is that the concepts of Degree of Rational Belief and Weight of Argument, which come from the Keynes theory of probability, when used together with the concept of routines, help understand the rationality of the decision-making process in introduction of an innovation.
Moeda endógena e passividade bancária: uma análise crítica da abordagem “horizontalista” e da “teoria do circuito monetário”
Authors: FREITAS MARIA CRISTINA PENIDO DE
Published: April 2022

RESUMO O objetivo deste artigo é apresentar uma análise crítica das abordagens pós-keynesianas que apoiam a tese de uma endogeneidade extrema da criação de dinheiro. Nem os horizontalistas nem os teóricos do circuito monetário dão atenção especial aos aspectos dual e dialético dos bancos, instituições orientadas para o lucro, responsáveis pela criação de dinheiro e pela intermediação financeira. Devido a esses aspectos, a concorrência bancária é o núcleo da instabilidade financeira e da dinâmica do crédito. Tendo como objetivo principal a competição por lucros, os bancos agem prociclicamente ajudando a ampliar a instabilidade da economia capitalista e a estimular atividades de especulação financeira em vez de investimentos industriais, fonte de riqueza e reprodução material nas economias capitalistas.
Ecophysiology of Mesosphaerum suaveolens (L.) Kuntze (Lamiaceae) under saline stress and salicylic acid
Authors: Nóbrega Jackson Silva , Figueiredo Francisco Romário Andrade , Silva Toshik Iarley da , Fátima Reynaldo Teodoro de , Ferreira Jean Telvio Andrade , Ribeiro João Everthon da Silva , Bruno Riselane de Lucena Alcântara
Published: April 2022

ABSTRACT: Mesosphaerum suaveolens (L.) Kuntze is a species widely used in folk medicine and has a high aromatic and therapeutic potential. However, its cultivation in semi-arid regions can be limited by salts in the irrigation water. The objective of this study was to evaluate the effect of salicylic acid (SA) as a mitigator of saline stress on the growth and gas exchange of M. suaveolens. The experimental design used was the randomized blocks in an incomplete factorial scheme (Central Composite Design), with five electrical conductivities water (ECw = 0.5, 1.45, 5.0, 8.55, and 10.0 dS m-1) and five SA doses (0.0, 0.29, 1.0, 1.71, and 2.0 mM). Plant height, number of leaves, stem diameter, leaf area, root length, and height/diameter ratio, and gas exchange (stomatal conductance, net CO2 assimilation rate, transpiration rate, instantaneous, and intrinsic water use efficiency, instantaneous carboxylation efficiency, and leaf temperature) were evaluated. The application of 0.9 mM SA attenuates the negative effect of saline stress on the number of leaves and leaf area of M. suaveolens. The application of SA stimulates the number of leaves, plant height, and root growth, but does not affect the gas exchange of M. suaveolens. ECw reduces the growth and gas exchange of M. suaveolens plants.
The changing of gelatin properties from tra catfish skin (Pangasianodon hypophthalmus) by alkaline replacement to enzyme in pretreated process
Authors: Thuy Le Thi Minh , Thanh Nguyen Van , Truc Tran Thanh
Published: April 2022

ABSTRACT: The effect of pretreated method to remove the non-collagenous protein by using alkaline and enzyme Alcalase, as well as the temperature and time for extracting on the properties of gelatin from tra catfish skin were investigated. Yields of gelatin extracted at 70 °C for 1h from pretreated skin by enzyme method (16.2%) was significantly higher than that of the sample by alkaline method (12.14%). However, the gel strength of gelatin from skin treated via enzyme Alcalase was lower than gelatin sample pretreated by alkaline while the turbidity values was higher than gelatin from skin pretreated via alkaline. From SDS-PAGE profile, gelatin from skin pretreated by alkaline consisted of two different α- chains in protein pattern while enzymatic gelatin had low molecular weight peptides. The FT-IR spectra showed the lower wavenumber in amide I and III of enzymatic gelatin in compare to alkaline gelatin by the loss of triple helical structure during enzyme treatment. From the results, the using enzyme for pretreated material has potential to replace the alkaline method for gelatin production with purpose to reduce chemical waste caused serious ecological issues.
FABREX: A NEW CLINICAL TEST FOR DIAGNOSIS GLUTEAL TENDINOPATHY
Authors: FREITAS ANDERSON , ROSA TATIANE MORELATI , MACEDO NETO SILVIO LEITE DE , BANDEIRA VANESSA DE CARVALHO , SOUTO DIOGO RANIER DE MACEDO , BARIN FABRÍCIO REICHERT
Published: April 2022

ABSTRACT Objective: This study aims to describe a simple and accurate semiological method executing a specific maneuver with the lower limb to direct the semiological investigation towards the tendinopathies in the gluteus medius and minimus. Methods: Fifty patients participated in the study, with a mean age of 44.1 ± 13 years, with persistent pain on the side of the hip for more than three months. To compare the FABREX (proposed test) and Lequesne semiological tests, in the diagnosis of tendinopathies in the gluteus medius and minimus, Magnetic Resonance Imaging (MRI) was adopted as the gold standard. Results: FABREX presented high sensitivity and moderate specificity for tendinopathy in the gluteus medius and high sensitivity and specificity for tendinopathy in the gluteus minimus. Conclusion: The proposed test, when positive, can be used to determine the diagnosis of gluteal tendinopathies (high specificity). Moreover, it has high sensitivity, excluding the diagnosis when negative. This study represents the initial step for validating the FABREX test, and can therefore be considered a simple and accurate procedure to identify patients with or without gluteal tendinopathies. Level of Evidence III, Case Control Study.
FUNCTIONAL EVALUATION OF THE RESULTS OF REPAIR OF PARTIAL AND COMPLETE ROTATOR CUFF TEARS
Authors: STORTI THIAGO , RAMOS ANNA BEATRIZ SALLES , FARIA RAFAEL SALOMON SILVA , COSTA GUILHERME BARBIERI LEME DA , PANIAGO ALEXANDRE FIRMINO
Published: April 2022

ABSTRACT Objective: To perform a comparative analysis of the results of arthroscopic surgical treatment of partial and complete rotator cuff (RC) injuries. Methods: Eighty-four shoulders with partial or complete RC tear that underwent arthroscopic repair were retrospectively evaluated using UCLA and Constant scores, assessment of strength, and range of motion. Fifty-seven shoulders with complete injuries and 27 with partial injuries were identified. Results: Age (p = 0.007) was higher in those with complete lesions (mean 61.4 ± 7.9 years), compared to those with partial lesions (mean 56.5 ± 7.1 years). The complete injuries group showed a higher elevation difference in relation to the contralateral shoulder compared to the partial injuries group (partial injuries: −1.1% vs complete injuries: −16.5%), statistically significant difference (p = 0.0004). In addition, complete lesions presented 96.5% of excellent and good results and a median of 35 in the UCLA score and partial lesions presented 84.6% of good/ excellent results and a median of 34. The Constant score showed 91.2% of satisfactory results in complete lesions and 77% in partial ones. Conclusion: Arthroscopic repair shows satisfactory functional results for both partial and complete rotator cuff injuries, with similar outcomes between groups. Level of Evidence III, Retrospective Comparative Study.
RADIOLOGICAL RESULTS OF SEVERE SCFE TREATMENT AT IOT-FMUSP FROM 2012 TO 2018
Authors: GABANA EDELVAN , MASSA BRUNO SERGIO FERREIRA , LUZO CARLOS AUGUSTO MALHEIROS , REIS PAULO ROBERTO DOS , SILVA JORGE DOS SANTOS , KOJIMA KODI EDSON
Published: April 2022

ABSTRACT Objective: To assess the complications in patients with severe slipped capital femoral epiphysis treated with the Dunn or modified Dunn procedure from 2012 to 2018 at the Institute of Orthopedics and Traumatology, Medical School, Universidade de São Paulo. Methods: Analysis of medical records, preoperative and postoperative radiographs with at least one year of radiographic follow-up of patients with severe slipped capital femoral epiphysis. Results: We reviewed the complications in 19 operated cases from 2012 to 2018, out of which 36.8% had osteonecrosis of the femoral head, one patient had chondrolysis, and another had postoperative infection. Conclusion: The osteonecrosis rate observed in this series of cases is similar to that described in other orthopedic facilities. We assessed factors that could potentially influence this outcome, including other characteristics of the patient (obesity, endocrine diseases, and history of sports activities) and of the health system. Level of Evidence III, Restropective Case Series.
Quercetin inhibits neutrophil extracellular traps release and their cytotoxic effects on A549 cells, as well the release and enzymatic activity of elastase and myeloperoxidase
Authors: Pereira G. S. , Percebom I. , Mendes S. , Souza P. S. S. , Diniz L. F. A. , Costa M. F. , Lopes B. R. P. , Toledo K. A.
Published: April 2022

Abstract Neutrophil extracellular traps (NETs) were first reported as a microbicidal strategy for activated neutrophils. Through an immunologic response against several stimuli, neutrophils release their DNA together with proteins from granules, nucleus, and cytoplasm (e.g., elastase and myeloperoxidase). To date, NETs have been implicated in tissue damage during intense inflammatory processes, mainly when their release is dependent on oxygen radical generation. Flavonoids are antioxidant and anti-inflammatory agents; of these, quercetin is commonly found in our daily diet. Therefore, quercetin could exert some protective activity against tissue damage induced by NETs. In our in vitro assays, quercetin reduced NETs, myeloperoxidase (MPO), and elastase release from neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA). The activity of these enzymes also decreased in the presence of quercetin. Quercetin also reduced the cytotoxic effect of NETs on alveolar cells (A549 cell line). Further, in silico assays indicated favorable interactions between quercetin and NET proteins (MPO and elastase). Overall, our results demonstrate that quercetin decreases deleterious cellular effects of NETs by reducing their release from activated neutrophils, and diminishing the enzymatic activity of MPO and elastase, possibly through direct interaction.
ARTRITE ENCEFALITE CAPRINA EM CABRITOS DE REBANHOS COM PROGRAMA DE CONTROLE NO ESTADO DO CEARÁ
Authors: Frota M.N.L. , Silva J.B.A. , Araújo S.A.C. , Teixeira M.F.S.
Published: April 2022

RESUMO A artrite encefalite caprina (CAE) doença vírica comum em cabras leiteiras. A introdução de animais infectados no rebanho é uma das formas de disseminação mais importantes, especialmente, pela dificuldade de diagnóstico nos estágios iniciais. Objetivou-se verificar o risco de disseminação da CAE através da comercialização de animais jovens soronegativos. Foram utilizados 46 animais da raça Saanen de aproximadamente 1 ano de idade, sendo todos filhos ou netos de animais soropositivos para CAE. Estes animais foram acompanhados clinicamente por 1 ano, sendo submetidos a 2 testes de imunodifusão em Gel de Agarose (IDGA), para a detecção de anticorpos anti-caev, feitos com intervalo de 6 meses. Ao final deste período os mesmos foram submetidos ao teste de Reação em Cadeia de Polimerase-Nested (PCR-Nested) para a detecção do DNA proviral em monócitos. Nos testes sorológicos apenas um animal apresentou resultado positivo no segundo exame, enquanto que no PCR-nested 35 mostraram-se positivos (76,08 %). Pode-se concluir que a aquisição de animais jovens, oriundos de propriedades com histórico de CAE, representa um alto risco na disseminação desta enfermidade, especialmente, quando se utiliza o teste de IDGA como único método de diagnóstico da infecção no momento da aquisição destes animais.