bluuebunny/crossref_metadata_2025 huggingface dataset:
Conditional relation between return and co-moments – an empirical study for emerging Indian stock market
Authors: Chaudhary Rashmi , Misra Dheeraj , Bakhshi Priti
Published: July 2020

Due to many theoretical and practical shortcomings of the traditional CAPM model, this study aims at analyzing the CAPM with possible extensions. The analysis aims to know the empirical soundness of Conditional Higher Moment CAPM in emerging India’s capital market. The sample consists of 69 company’s daily stock price data from April 2004 to March 2019 from NSE 100. Panel data analysis is used on 21 cross-sections. The overall results show that when both up and down markets are incorporated separately, all three moments, namely, co-variance, co-skewness, and co-kurtosis, are priced during the normal Indian economy phase. Further, this study states that including higher moments (co-skewness and co-kurtosis) in the two-moment model provides symmetry in both the up and down markets. This is one of the first studies in the Indian Stock market explaining the variation in portfolio returns through panel data analysis by extending CAPM with conditional higher-order co-moments. The portfolio managers should consider skewness and kurtosis along with variance in constructing the optimal portfolios.
Derivative trading and structural breaks in volatility in India: an ICSS approach
Authors: Anjana Raju Guntur , Shirodkar Sanjeeta
Published: July 2020

Researchers argue that ignoring the structural breaks in the time-series variance can cause significant upward biases in the degree of persistence in estimated GARCH models. Against this backdrop, the present study empirically examines the effect of stock futures on the underlying stock’s volatility in India by incorporating the structural breaks with the help of ICSS test and AR (1)-GARCH (1, 1) model for 30 most liquid and actively traded underlying stocks and their associated futures contracts. The study period ranges from the 1st January 2000 or the listing date of the particular stock (whichever is prior) till 31st March 2019. The study contributes to the on-going debate regarding the effect of derivatives on the underlying stock market’s volatility in two ways. Firstly, by taking into consideration the breaks in the volatility and, secondly, studying the effect of single stock futures will allow us to evaluate company-specific response to futures trading directly. The study offers a mixed outcome for the stocks under consideration. However, there is evidence of a decline in unconditional volatility for the majority of the stocks. The overall findings indicate that trading in stock futures may not have any detrimental effect on the underlying stock’s volatility.
MODIFICATION OF ALEXNET ARCHITECTURE FOR DETECTION OF CAR PARKING AVAILABILITY IN VIDEO CCTV
Authors: Tanuwijaya Evan , Fatichah Chastine
Published: July 2020

The difficulty of finding a parking space in public places, especially during peak hours is a problem experienced by drivers. To assist the driver in finding parking space availability, a system is needed to monitor parking availability. One study to detect the availability of parking lots utilizing CCTV. However, research on the availability of parking spaces on CCTV data has several problems, detecting parking slots that are done manually to be inefficient when applied to different parking lots. Also, research to detect the availability of parking lots using the Convolution Neural Network (CNN) method with existing architecture has many parameters. Therefore, this study proposes a system to detect the availability of car parking lots using You Only Look Once (YOLO) V3 for marking the parking space and proposed a new architecture CNN called Lite AlexNet which has few parameters than other methods to speed up the process of detecting parking space availability. The best accuracy of the marking stage using YOLO V3 is 92.31% where the weather was cloudy. For the proposed Lite AlexNet get the best time training average which is 7 second compare to other existing methods and the average accuracy in every condition is 92.33% better than other methods.
A COMPARISON OF CLUSTERING BY IMPUTATION AND SPECIAL CLUSTERING ALGORITHMS ON THE REAL INCOMPLETE DATA
Authors: Ananda Ridho , Dewi Atika Ratna , Nurlaili Nurlaili
Published: July 2020

The existence of missing values will really inhibit process of clustering. To overcome it, some of scientists have found several solutions. Both of them are imputation and special clustering algorithms. This paper compared the results of clustering by using them in incomplete data. K-means algorithms was utilized in the imputation data. The algorithms used were distribution free multiple imputation (DFMI), Gabriel eigen (GE), expectation maximization-singular value decomposition (EM-SVD), biplot imputation (BI), four algorithms of modified fuzzy c-means (FCM), k-means soft constraints (KSC), distance estimation strategy fuzzy c-means (DESFCM), k-means soft constraints imputed-observed (KSC-IO). The data used were the 2018 environmental performance index (EPI) and the simulation data. The optimal clustering on the 2018 EPI data would be chosen based on Silhouette index, where previously, it had been tested its capability in simulation dataset. The results showed that Silhouette index have the good capability to validate the clustering results in the incomplete dataset and the optimal clustering in the 2018 EPI dataset was obtained by k-means using BI where the silhouette index and time complexity were 0.613 and 0.063 respectively. Based on the results, k-means by using BI is suggested processing clustering analysis in the 2018 EPI dataset.
MACHINE LEARNING FOR DATA CLASSIFICATION IN INDONESIA REGIONAL ELECTIONS BASED ON POLITICAL PARTIES SUPPORT
Authors: Fachrie Muhammad
Published: July 2020

In this paper, we discuss the implementation of Machine Learning (ML) to predict the victory of candidates in Regional Elections in Indonesia based on data taken from General Election Commission (KPU). The data consist of composition of political parties that support each candidate. The purpose of this research is to develop a Machine Learning model based on verified data provided by official institution to predict the victory of each candidate in a Regional Election instead of using social media data as in previous studies. The prediction itself simply a classification task between two classes, i.e. ‘win’ and ‘lose’. Several Machine Learning algorithms were applied to find the best model, i.e. k-Nearest Neighbors, Naïve Bayes Classifier, Decision Tree (C4.5), and Neural Networks (Multilayer Perceptron) where each of them was validated using 10-fold Cross Validation techniques. The selection of these algorithms aims to observe how the data works on different Machine Learning approaches. Besides, this research also aims to find the best combination of features that can lead to gain the highest performance. We found in this research that Neural Networks with Multilayer Perceptron is the best model with 74.20% of accuracy.
SPAMMER DETECTION BASED ON ACCOUNT, TWEET, AND COMMUNITY ACTIVITY ON TWITTER
Authors: Priyatno Arif Mudi
Published: July 2020

Spammers are the activities of users who abuse Twitter to spread spam. Spammers imitate legitimate user behavior patterns to avoid being detected by spam detectors. Spammers create lots of fake accounts and collaborate with each other to form communities. The collaboration makes it difficult to detect spammers' accounts. This research proposed the development of feature extraction based on hashtags and community activities for the detection of spammer accounts on Twitter. Hashtags are used by spammers to increase popularity. Community activities are used as features for the detection of spammers so as to give weight to the activities of spammers contained in a community. The experimental result shows that the proposed method got the best performance in accuracy, recall, precision and g-means with are 90.55%, 88.04%, 3.18%, and 16.74%, respectively.  The accuracy and g-mean of the proposed method can surpassed previous method with 4.23% and 14.43%. This shows that the proposed method can overcome the problem of detecting spammer on Twitter with better performance compared to state of the art.
SENTIMENT ANALYSIS ON E-SPORTS FOR EDUCATION CURRICULUM USING NAIVE BAYES AND SUPPORT VECTOR MACHINE
Authors: Ardianto Rian , Rivanie Tri , Alkhalifi Yuris , Nugraha Fitra Septia , Gata Windu
Published: July 2020

The development of e-sports education is not just playing games, but about start making, development, marketing, research and other forms education aimed at training skills and providing knowledge in fostering character. The opinions expressed by the public can take form support, criticism and input. Very large volume of comments need to be analyzed accurately in order separate positive and negative sentiments. This research was conducted to measure opinions or separate positive and negative sentiments towards e-sports education, so that valuable information can be sought from social media. Data used in this study was obtained by crawling on social media Twitter. This study uses a classification algorithm, Naïve Bayes and Support Vector Machine. Comparison two algorithms produces predictions obtained that the Naïve Bayes algorithm with SMOTE gets accuracy value 70.32%, and AUC value 0.954. While Support Vector Machine with SMOTE gets accuracy value 66.92% and AUC value 0.832. From these results can be concluded that Naïve Bayes algorithm has a higher accuracy compared to Support Vector Machine algorithm, it can be seen that the accuracy difference between naïve Bayes and the vector machine support is 3.4%. Naïve Bayes algorithm can thus better predict the achievement of e-sports for students' learning curriculum.
A NEW SPECIES OF ORIBATID MITES OF THE GENUS GALUMNA FROM SOUTH AFRICA
Authors: Ermilov Sergey G. , Hugo-Coetzee Elizabeth
Published: July 2020

A new oribatid mite species of the genus Galumna (Oribatida, Galumnidae) is described from South Africa, based on museum collection material. Galumna (Galumna) paralawrencei sp. n. differs from Galumna (Galumna) lawrencei Jacot, 1940 by the larger body size, the localization of adanal lyrifissures, and the presence of a hump-like structure in the anterior part of the prodorsum and distinctly longer notogastral porose areas Aa, A2, A3 and anal and adanal setae.
A PRELIMINARY REPORT ON MITES (ACARI) ASSOCIATED WITH THE SMALL SPRUCE BARK BEETLE IPS AMITINUS (COLEOPTERA: CURCULIONIDAE: SCOLYTINAE) IN WESTERN SIBERIA
Authors: Khaustov Alexander A. , Kerchev Ivan A.
Published: July 2020

The small spruce bark beetle Ips amitinus has recently been found in two West Siberian regions: Tomsk and Kemerovo. Here, we collected and identified the mites associated with I. amitinus that naturally colonized branches and twigs of Siberian pine, Pinus sibirica, in Western Siberia, Russia. Five mites species were revealed: Dendrolaelaps quadrisetus (Digamasellidae), Proctolaelaps hystricoides (Melicharidae), Iponemus leionotum and I. asiaticus (Tarsonemidae), as well as Ereynetes (Huntereynetes) sp. (Ereynetidae). Interestingly, phoresy of two species of Iponemus was observed on one host beetle. Three of the five species are known predators and parasitoids of eggs or larvae of bark beetles and could be targeted for biological control of I. amitinus in Russia.
A NEW SPECIES OF LORRYIA (ACARI: TYDEIDAE) FROM A TERMITE NEST IN SOUTH AFRICA
Authors: Khaustov Alexander A. , Hugo-Coetzee Elizabeth , Ermilov Sergey G.
Published: July 2020

A new species—Lorryia pseudoplacita sp. n.—is described from central South Africa. It was collected from a nest of the termite Trinervitermes trinervoides (Sjöstedt, 1911) (Isoptera: Termitidae). The new species differs from L. placita in the shape of the dorsal setae and in having a shorter palptarsus.
ON THE SYSTEMATICS OF THE PIONA NODATA AND THE P. COCCINOIDES COMPLEXES IN RUSSIA (ACARI: HYDRACHNIDIA, PIONIDAE) WITH THE DESCRIPTION OF A NEW SPECIES
Authors: Tuzovsky Petr V.
Published: July 2020

This study presents a detailed taxonomic review of water mites of the Piona nodata and the P. coccinoides complexes (Pionidae, Piona), found in Russia. The review includes illustrations, descriptions and redescriptions of 11 Piona species found in Russia: Piona accepta sp. n.; P. ambigua (Piersig, 1894); P. annulata (Thor, 1901); P. caucasica Tuzovskij, 2019; P. coccinoides (Thor, 1897); P. inflata Sokolow, 1927; P. laminata (Thor, 1901); P. magadanensis Tuzovskij, 2013; P. neococcinoides Tuzovskij, 2019; P. nodata (Müller, 1776); and P. nodatella Tuzovskij, 2015.
Religious Faith And The Types Of Rationality
Authors: Jasiński Karol
Published: July 2020

The purpose of this article is to determine the nature of religious faith and various types of rationality, with special emphasis on instrumental rationality, to characterise the link between faith and reason, and to reveal the insufficiency of instrumental reason in the sphere of faith. Instrumental reason is limited to the practical pursuits, which forces man to rely on a different type of mental activity in other spheres of life, such as religiousness. The paper is divided into three parts. The first section presents the nature of religious faith (religious faith as a psychological attitude of the followers and as a set of theses accepted in a given religion; existential and cognitive dimension of faith; the relationship between faith and revelation; assertion of religious truth). The second section outlines the nature of modern rationality (pluralism of rationality, its types, instrumental reason). The third section focuses on the relationship between religious faith and human reason (ratio, substantial reason, intellect).
Zacopride Exerts an Antiarrhythmic Effect by Specifically Stimulating the Cardiac Inward Rectifier Potassium Current in Rabbits: Exploration of a New Antiarrhythmic Strategy
Authors: Lin Yuanyuan , Li Junhu , Zhu Baozhong , Liu Qinghua , Bai Xiaojie , Chang Bingmei , Guo Yanlin , Feng Qilong , Li Xuewen , Wu Bowei , Cao Jimin
Published: July 2020

Background:

Zacopride, a potent antagonist of 5-HT3 receptors and an agonist of 5-HT4 receptors, is a
gastrointestinal prokinetic agent. In a previous study, we discovered that zacopride selectively stimulated the inward
rectifier potassium current (IK1) in the rat and that agonizing IK1 prevented or eliminated aconitine-induced arrhythmias
in rats.

Objective:

Our aims were to confirm that the antiarrhythmic effects of zacopride are mediated by selectively enhancing
IK1 in rabbits.

Methods:

The effects of zacopride on the function of the main ion channels were investigated using a whole-cell
patch-clamp technique in rabbits. Effects of zacopride on cardiac arrhythmias were also explored experimentally
both in vivo and in vitro.

Results:

Zacopride moderately enhanced cardiac IK1 but had no apparent action on voltage-gated sodium current
(INa), L- type calcium current (ICa-L), sodium-calcium exchange current (INa/Ca), transient outward potassium current
(Ito), or delayed rectifier potassium current (IK) in rabbits. Zacopride also had a marked antiarrhythmic effect
in vivo and in vitro. We proved that the resting membrane potential (RMP) was hyperpolarized in the presence of 1
μmol/L zacopride, and the action potential duration (APD) at 90% repolarization (APD90) was shortened by zacopride
(0.1-10 μmol/L) in a concentration- dependent manner. Furthermore, zacopride at 1 μmol/L significantly
decreased the incidence of drug-induced early afterdepolarization (EAD) in rabbit ventricular myocytes.

Conclusion:

Zacopride is a selective agonist of rabbit cardiac IK1 and that IK1 enhancement exerts potential antiarrhythmic
effects.
Novel Nanocarriers for the Treatment of Wound Healing
Authors: Krishnaswami Venkateshwaran , Raju Nikhishaa Sree , Alagarsamy Shanmugarathinam , Kandasamy Ruckmani
Published: July 2020

The sequence of biochemical and cellular responses restoring the integrity of the subcutaneous tissue
of the skin is termed as wound healing. Inflammatory cytokine suppression and inflammatory transduction cascades
are the major targets for wound healing. Formulations for wound healing should promote neovascularization
and angiogenic pathways by increasing the expression of vascular endothelial growth factor, fibroblast
growth factor, and platelet-derived growth factor. Medication used for wound healing promotes antiinflammatory
associated with anti-bacterial action. In order to boost the effectiveness of current medical treatments,
the cutting-edge nanotechnology offers many novel therapies. This review summarized and discussed
wound healing, types of wounds, natural materials used for wound healing, metallic nanoparticles and current
nano drug delivery systems used for wound healing with special emphasis on the angiogenesis role in the healing
of wounds.
Modulation of Vascular Function by Perivascular Adipose Tissue: Sex Differences
Authors: Victorio Jamaira A. , da Costa Rafael M. , Tostes Rita C. , Davel Ana P.
Published: July 2020

In addition to the endothelium, the perivascular adipose tissue (PVAT) has been described to be involved in the local modulation of vascular function by synthetizing and releasing vasoactive factors. Under physiological conditions, PVAT has anticontractile and anti-inflammatory effects. However, in the context of hypertension, obesity and type 2 diabetes, the PVAT pattern of anticontractile adipokines is altered, favoring oxidative stress, inflammation and, consequently, vascular dysfunction. Therefore, dysfunctional PVAT has become a target for therapeutic intervention in cardiometabolic diseases. An increasing number of studies have revealed sex differences in PVAT morphology and in the modulatory effects of PVAT on endothelial function and vascular tone. Moreover, distinct mechanisms underlying PVAT dysfunction may account for vascular abnormalities in males and females. Therefore, targeting sex-specific mechanisms of PVAT dysfunction in cardiovascular diseases is an evolving strategy for cardiovascular protection.
Conduction Disorders in the Setting of Acute STEMI
Authors: Nikus Kjell , Birnbaum Yochai , Fiol-Sala Miquel , Rankinen Jani , de Luna Antoni Bayés
Published: July 2020

:

ST-elevation myocardial (STEMI) is frequently associated with conduction disorders.
Regional myocardial ischemia or injury may affect the cardiac conduction system at various locations,
and neural reflexes or changes in the balance of the autonomous nervous system may be involved.
Sinoatrial and atrioventricular blocks are more frequent in inferior than anterior STEMI,
while new left anterior fascicular block and right bundle branch block indicate proximal occlusion
of the left anterior descending coronary artery. New left bundle branch block is associated with
multi-vessel disease.

:

Most conduction disorders associated with STEMI are reversible with reperfusion therapy, but they
may still impair prognosis because they indicate a large area at risk, extensive myocardial infarction
or severe coronary artery disease.

:

Acute STEMI recognition is possible in patients with a fascicular or right bundle branch block, but
future studies need to define the cut-off values for ST depression in the leads V1-V3 in inferolateral
MI and for ST elevation in the same leads in anterior STEMI. In the left bundle branch block, concordant
ST elevation is a specific sign of acute coronary artery occlusion, but the ECG feature has
low sensitivity.
Association between Serum Vitamin D Level and Echocardiographic Abnormalities in Patients with Thalassemia Major
Authors: Pishgahi Mehdi , Niroomand Mahtab , Bozorgmehr Rama , Ghane-Fard Shirin , Mousavi Farideh , Tabary Mohammadreza , Khaheshi Isa
Published: July 2020

Objectives:

Thalassemia major (TM) is one of the most common blood disorders with a high mortality rate due to cardiovascular disease. Vitamin D deficiency has been suggested to implicate in cardiac abnormalities. In this prospective study, we aimed to investigate the relationship between serum levels of vitamin D and tissue Doppler (TD) echocardiographic indices in thalassemia major patients.

Methods:

A total of 81 TM patients, including 56 females and 25 males, with a mean age of 27.5± 6.8 years, were enrolled consecutively. Serum levels of vitamin D and other biomedical parameters were measured. Then, all patients were subjected to TD echocardiography. Correlations between the serum parameters and systolic and diastolic indices were examined.

Results:

The serum level of vitamin D was correlated with systolic and diastolic indices such as the EF (r= 0.33, P= 0.003) and TD Imaging (TDI)-lateral (r= 0.31, P= 0.005). However, no correlations were observed between vitamin D deficiency and the LV septal and posterior wall thickness, TDIseptal, tricuspid regurgitation peak gradient (TRPG), pulmonary artery systolic pressure (PASP), deceleration time (DT), and propagation velocity (PVcm/s) indices. The results revealed also no linear correlations between serum vitamin D and albumin (r= -0.17, P= 0.06), ALP (r= -0.12, P= 0.14), T4 (r= -0.11, P= 0.16), as well as TSH (r= -0.10, P= 0.19).

Conclusions:

It seems that vitamin D deficiency in patients with TM is associated with systolic but not diastolic dysfunctions, possibly as consequences of related biochemical abnormalities.
Polymeric Nanoparticles Loaded with Acyclovir: Formulation, Characterization and In-Vitro Drug Prolonged-Release Study
Authors: Yen Tran Thi Hai , Linh Nguyen Tran , Giang Vu Thi Thu , Anh Hoang Lan
Published: July 2020

Objectives:

Acyclovir (ACV) is an antiviral drug, which requires frequent dosing
regimen because of poor oral bioavailability and short half-life. In this study, ACV
nanoparticles were formulated using ammonium methacrylates copolymers such as Eudragit
RS 100 (Eud RS) and Eudragit RL 100 (Eud RL) to prolong release drug, and increase
bioavailability.

Methods:

ACV loaded nanoparticles were prepared by the solvent replacement technique
and then were characterized by particle size, distribution, entrapment efficiency, differential
scanning calorimeter, transmission electron microscope, and in-vitro drug release.

Results:

It was found that as drug:polymer ratio changed from 1:2 to1:5, particle size and
drug entrapment efficiency increased significantly. ACV– Eud RS loaded nanoparticles
had a larger mean diameter of 363 nm in comparison to 200 nm of ACV- Eud RL nanoparticles.
DSC results showed that in the prepared ACV-Eud RS nanoparticles, the drug
was presented in the amorphous phase and may have been molecularly dispersed in the
polymer matrix, but in the ACV-Eud RL nanoparticles, the drug was presented in the particles
and homogeneously dispersed in the polymeric matrix. The entrapment efficiency
of AVC-Eud RS nanoparticles was higher than that of ACV-Eud RL nanoparticles.
In vitro drug release study showed that the ratios of released drug from ACV-Eud RS nanoparticles
in the range from 58±3.8 to 62.9±4.6%, which was lower than those from
ACV-Eud RL nanoparticles, in the range from 73.3±4.9 to 77.9±2.9%. The release was
found to follow the Weibull model with a Fickian diffusion mechanism for both ACVEud
RS and ACV- Eud RL nanoparticles.

Conclusion:

These results suggest that ACV nanoparticles based on Eud RS100 and Eud
RL100 could prolong the release of the drug.
Revealing Potential Binding Affinity of FDA Approved Therapeutics Targeting Main Protease (3CLpro) in Impairing Novel Coronavirus (SARSCoV- 2) Replication that Causes COVID-19
Authors: Sivaraman D. , Pradeep P.S. , Manoharan S. Sundar , Bhat C. Ramachandra , Leela K.V. , Venugopal V.
Published: July 2020

Background:

Spread of COVID-19 attains a crucial transition in reveling its pandemic across
the boundaries. In combating the infection caused by SARS-CoV-2, there is a spectrum of ideal strategies
that have been adopted globally, of which repurposing of approved drugs considerably having high
clinical relevance. 3-chymotrypsin-like protease (3CL pro) is considered to be the potential target for the
researchers as it is highly essential for cleavage of polyprotein to get 16 nonstructural proteins (called
nsp1-nsp16). These proteins are highly essential for viral replication and hence become a primary target
for enzyme inhibitors. 3CL pro, having a structural projectile helical chain with biologically active site
involved in processing viral polyproteins that are evolved from RNA genome translation.

Objective:

The major objective of the present investigation is to evaluate the enzyme inhibition potential
of FDA approved therapeutic leads in targeting 3CLpro that medicates the viral replication.

Methods:

Docking calculations were carried out for an array of FDA approved molecules which leads to
a notable few molecules such as Emtricitabine, Oseltamivir, Ganciclovir, Chloroquine, Baricitinib,
Favipiravir, Lopinavir, Ritonavir, Remdesivir, Ribavirin, Tenofovir, Umifenovir, Carbapenam, Ertapenem
and Imipenam which have both specificity and selectivity in terms of binding efficiency against
3CL proenzyme.

Results:

A combinatorial evaluation employing in-silico screening shows a major lead for remdesivir
which possesses a substantial affinity to 3CL pro binding on core amino acid residues, such as Leu 27,
His 41, Gly 143, Cys 145, His 164, Met 165, Glu 166, Pro 168 and His 172 which share the biological
significance in mediating enzymatic action. Results of docking simulation by Autodock over a host of
FDA approved molecules show high degree of selectivity and specificity in the increasing order of binding
capacity; Remdesivir> Ertapenem> Imipenam> Tenofovir> Umifenovir> Chloroquine> Lopinavir>
Ritonavir> Emtricitabine> Ganciclovir> Baricitinib> Ribavirin>Oseltamivir>Favipiravir> Carbapenam.

Conclusion:

Till date, there is no known cure attained for treating COVID-19 infection. In conclusion,
lead molecules from already approved sources provoke promising potential which grabs the attention of
the clinicians in availing potential therapeutic candidate as a drug of choice in the clinical management
of COVID-19 time-dependently.
Educação de jovens e adultos e desenvolvimento local em comunidades quilombolas rurais brasileiras
Authors: Bacheti Luciane , Loureiro Armando , Cristóvão Artur , Salles Alexandre
Published: July 2020

Este artigo aborda a educação de jovens e adultos (EJA) como força catalisadora da participação comunitária e de processos de desenvolvimento local no contexto de uma comunidade quilombola rural brasileira. Em tal contexto se buscou compreender melhor qual o papel da educação de jovens e adultos, identificando fatores que potencializam ou que inibem processos educativos articulados com dinâmicas de desenvolvimento local. O desenho metodológico se pautou por abordagens participativas centradas na pesquisa-ação, implicando lideranças quilombolas na construção compartilhada de processos educativos não formais definidos por elas como prioritários. Para tanto, propôs-se o Programa EJA e Desenvolvimento Local, vinculado a uma instituição educacional, que materializou atividades educativas não formais referentes à homeopatia rural; técnicas em armazenamento de água; e roteiro turístico quilombola de base comunitária. Um dos principais desafios identificados foi a organização de tempos-espaços favoráveis à participação comunitária. Contudo, os principais resultados apontaram a educação de jovens e adultos como ferramenta de participação comunitária e mediadora de conflitos endógenos por meio dos círculos de diálogo, que geraram aprendizagens colaborativas, engajando quilombolas e parceiros externos na busca de soluções dos problemas comunitários inibidores de processos estruturantes de desenvolvimento local.
La subtribu Plucheinae (Inuleae, Asteraceae) en México: taxonomía, diversidad y distribución
Authors: Redonda Martínez Rosario
Published: July 2020

Antecedentes y Objetivos: La subtribu Plucheinae es un grupo escasamente representado en México y por ello no debería presentar problemas taxonómicos. Sin embargo, esto no es así, pues se han confundido taxones con hábitos de crecimiento contrastantes como Pluchea carolinensis y P. odorata. Además, se ha reportado la presencia de especies de otros países debido a identificación errónea, de ahí la necesidad de generar un tratamiento taxonómico actualizado. El objetivo de este trabajo es presentar una sinopsis taxonómica actualizada de las Plucheinae mexicanas, incluyendo claves de identificación y descripciones de géneros y especies.Métodos: Se hizo una revisión de trabajos florístico-taxonómicos de las tribus Inuleae y Plucheeae realizados previamente en México, para generar un listado actualizado de especies mexicanas que posteriormente se cotejó con ejemplares herborizados depositados en las colecciones científicas mexicanas ENCB, FCME, IEB y MEXU, además de herbarios en línea de los Estados Unidos de América.Resultados clave: En México, Pluchea es el género más diverso de la subtribu Plucheinae y de distribución más amplia, agrupa ocho especies y dos categorías infraespecíficas, se encuentra en 27 estados. Oaxaca y Veracruz concentran el mayor número de especies, y la menor diversidad está en Aguascalientes, Ciudad de México y Durango, donde se registra únicamente un taxón. Las Plucheinae ocurren en elevaciones desde el nivel del mar hasta 3100 m s.n.m. y tienen afinidad por ambientes con humedad elevada.Conclusiones: El agrupamiento de las cabezuelas y el tipo de indumento en los filarios han sido caracteres útiles para diferenciar taxones mexicanos del complejo P. foetida; sin embargo, es necesario realizar estudios anatómicos y micromorfológicos en este complejo para corroborar su separación.
Rare case of urethral duplication in the boy
Authors: Kagantsov I. M. , Sannikov I. A. , Golovin A. V. , Svarich V. G.
Published: July 2020

A non-typical variant of Y-type urethral duplication has been described in the article. In this case, the surgical treatment decision was not difficult. Y-type urethral duplication was exposed up to the sinus, and its dissection was performed, followed by urethroplasty. This variant of Y-type urethral duplication has not been described in the world literature available to us, and, in our opinion, it is important for gaining experience in treating rare variants of congenital anomalies of the urethra.
Intraoperative JJ-stent placement during laparoscopic procedure
Authors: Kochkin A. D.
Published: July 2020

Various options of JJ placement during different laparoscopic upper urinary tract procedures are described herein “Tips & Tricks” manner. Author’s “Lifehacks” to make this manipulation easier is also presented.
Intravesical and extravesical ureteral reimplantation in children with bilateral refluxing megaureter: comparison of results
Authors: Dubrov V. I. , Kagantsov I. M.
Published: July 2020

Introduction. Extravesical ureteral reimplantation is an accepted technique for the surgical treatment of high-grade vesicoureteral reflux. However, many surgeons continue to use an intravesical technique, including for the megaureter. We present our experience and outcomes with these techniques for primary bilateral refluxing megaureter.

Purpose of the study. To improve the results of surgical treatment of refluxing megaureter in children.

Materials and methods. A retrospective study was performed of 95 patients who underwent ureteral reimplantation between 2006 and 2019. The age of patients at the time of surgery was from 4 months to 13 years (median — 27.6 months), boys were 71 (74.7%), girls were 24 (25.3%). All patients are divided into 2 groups depending on the method of treatment. Group 1 consisted of 65 patients who underwent Cohen single-stage bilateral transvesical ureteral reimplantation. Group 2 included 30 children who underwent two-stage Barry extravesical ureteral reimplantation. The interval between operations was from 1 to 63 months (median — 5.2 months). Patient demographics, surgical technique and outcomes were recorded. A successful postoperative outcome was defined as improved hydronephrosis and no vesicoureteral reflux.

Results. Median follow-up period was 3.2 years. The overall success rate was 80% for patients and 88% for ureters. Postoperative grade III – IV reflux had 15 patients (15,8%) and 16 ureters (8,4%). Persistent ureterohydronephrosis had 4 children (4,2%) and 6 ureters (3,2%). The effectiveness of treatment for patients in the Cohen group was 77%, in the Barry group — 87% (p = 0.408), for ureters — 86% and 93%, respectively (p = 0.223). The difference was not significant despite the higher effectiveness extravesical technique.

Conclusion. Extravesical and transvesical ureteral reimplantation are effective methods of treatment for bilateral refluxing megaureter in children.
Post-finasteride syndrome: our current knowledge
Authors: Galushkin A. A. , Likhikh D. G. , Kogan M. I.
Published: July 2020

5-α reductase inhibitors are effective and commonly used medications for the treatment of benign prostatic hyperplasia. However, there are some questions about the safety of such medications. A post-finasteride syndrome is a controversial syndrome associated with a constellation of sexual, physical, and psychological symptoms that develop during or after finasteride exposure and persist after discontinuation. Finasteride and dutasteride have the same mechanism of action and we can suppose that the term «post-finasteride syndrome» may apply to the whole group of 5-alfa reductase inhibitors. Nowadays, reasons and development mechanisms of this syndrome are unclear. The results of studies on sexual, physical, and psychological disorders have shown mixed results. Some experts attribute post-finasteride syndrome to a group of «mysterious diseases» based on psychosocial factors. Also, we need new studies with better design because reasons and development mechanisms of this syndrome are unclear.

Aleksandr A. Galushkin and Dmitriу G. Likhikh are employees GlaxoSmithKline Trading, Michael I. Kogan declares no conflict of interest.
Platelet-rich autologous plasma: what is it and for what?
Authors: Medvedev V. L. , Kogan M. I. , Mihailov I. V. , Lepetunov S. N.
Published: July 2020

Platelet-rich autologous plasma (PRP) is often used in various branches of medicine. The scope of PRP therapy has expanded from stimulating bone regeneration, healing wounds and ulcers, and musculoskeletal injuries to improving the ability to engrave various types of grafts. Due to the natural properties of platelet-rich plasma, its introduction into the human body is one of the most promising procedures for tissue restoration. After the destruction of platelets, PRP contains α-granules, from which many factors are released after activation, such as transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VGFF) and epidermal growth factor (EGF). The current state of the problem of using APOT has a huge perspective on the development of the methodology, which is due to many aspects that make this procedure simple. PRP can improve the course of many urological diseases, such as erectile dysfunction, Peyronie’s disease, urethral stricture, vesicovaginal fistulas, interstitial cystitis, and stress urinary incontinence. There are many protocols for preparing PRP, each of which has its standardized parameters and stated results. The article presents a review of the literature on the use of platelet-rich plasma in urology, focuses on the definition of PRP, various methods of preparation and activation, as well as the concentration of growth factors.
Erectile dysfunction: new technologies and approaches in diagnostics and treatment
Authors: Popov S. V. , Orlov I. N. , Grin’ Ye. A. , Malevich S. M. , Gul’ko A. M. , Topuzo T. M. , Kyzlasov P. S. , Povelitsa E. A.
Published: July 2020

The analysis of literature data (PubMed and RSCI databases) is presented, which is devoted to new approaches and technologies in the diagnosis and treatment of various forms of erectile dysfunction (ED). ED is a very significant clinical and social problem at the present stage, which has a significant negative impact on the quality of life of men. The importance and relevance of the ED problem dictate the need to search for and develop new, more effective technologies for ED verification and treatment. This review study confirms the fact that the main diagnostic task in ED is to establish its true etiological component. A rational approach is to use research methods with proven effectiveness since this circumstance will ensure effective treatment of ED. Currently, there is a need to create a personalized diagnostic algorithm aimed at assessing the state of the cardiovascular system, endothelium, androgen status, angioarchitectonics, etc. This will increase the effectiveness and safety of treatment for men suffering from various forms of ED. X-ray endovascular, cellular and new technologies in the field of falloprosthesis are very promising with encouraging primary results.
Competitiveness of Mexican pension funds and regulatory policy
Authors: Martinez Gabriel
Published: July 2020

Se evalúa la competitividad de los fondos de pensión obligatorios mexicanos y el impacto de la deuda pública sobre los rendimientos. Se calculan detalladamente comisiones y tasas de rendimiento, y su relación con tasas pagadas por bonos federales. Mediante modelos de regresión de efectos fijos y SUR se mide el impacto de la deuda pública sobre los rendimientos. Los resultados muestran que: (a) estos fondos son la mejor opción de ahorro disponible para los trabajadores; (b) los proveedores convergieron a comisiones similares medidas en pesos; (c) los rendimientos son históricamente muy similares entre los proveedores; (d) el riesgo de pérdidas aumenta por una diversificación inadecuada; y (e) una mayor deuda pública bajo los rendimientos. Recomendaciones de política pública: (i) un menor peso de la deuda pública y diversificación internacional pueden mejorar los rendimientos; (ii) los trabajadores deben ser informados del valor monetario de las comisiones. No se estudian los efectos sobre trabajadores de diferentes niveles salariales o el rol de la informalidad. El cálculo detallado de comisiones, tasas de rendimiento e impacto de la deuda pública, es una contribución original.
Confiabilidad y validez de un instrumento de selección de capital humano
Authors: Terán-Bustamante Antonia , Ramírez-Castillo Claudia Estrella , Martínez-Velasco Antonieta
Published: July 2020

El objetivo de esta investigación es analizar la validación y confiabilidad de un instrumento para la selección de capital humano en las organizaciones enfocado a la confianza-integridad. Para evaluar la confiabilidad y validez del instrumento se realizan dos tipos de análisis, el primero con modelos de la teoría clásica mediante el Alpha de Cronbach y el estadístico Kuder-Richardson 20. El segundo análisis se realiza utilizando la Teoría de Respuesta al Item (TRI) a través del modelo de Rasch, utilizando programación en R. El test desarrollado se realiza con enfoque en psicopatía organizacional. La evidencia encontrada muestra confiabilidad y validez en la prueba analizada, tanto para la valoración de las preguntas como para la fiabilidad en la selección de los individuos analizados. Así mismo, el modelo de Rach aporta información valiosa a nivel preguntas y sujetos para tener un mejor instrumento. Esta investigación aporta conocimiento en dos sentidos i) en los test de personalidad aplicados en las organizaciones para la selección de capital humano en forma más confiable y ii) en mostrar una metodología que puede ser aplicada a cualquier cuestionario para la validación y confiabilidad de sus respuestas.
Isotherm adsorption characteristics of carbon microparticles prepared from pineapple peel waste
Authors: Nandiyanto Asep Bayu Dani , Santiuly Girsang Gabriela Chelvina , Maryanti Rina , Ragadhita Risti , Anggraeni Sri , Fauzi Fajar Miraz , Sakinah Putri , Astuti Asita Puji , Usdiyana Dian , Fiandini Meli , Dewi Mauseni Wantika , Al-Obaidi Abdulkareem Sh. Mahdi
Published: July 2020

The objective of this study was to investigate isotherm adsorption of carbon microparticles from pineapple peel waste. Carbon microparticles were prepared by carbonizing pineapple peel waste at 215-250°C and grinding using a saw-milling process. To investigate adsorption properties of carbon microparticles, experiments were done by evaluating adsorption of curcumin (as a model of adsorbate) in the ambient temperature and pressure under constant pH condition. To confirm the adsorption characteristics, carbon particles with different sizes (i.e., 100, 125, and 200 ?m) were tested, and the adsorption results were compared with several standard isotherm adsorption models: Langmuir, Freundlich, Temkin, and Dubinin- Radushkevich. To support the adsorption analysis, several characterizations (i.e., optical microscope, sieve test, and Fourier transform infrared analysis) were conducted. The adsorption test showed that the adsorption profile is fit to the Freundlich model for all variations, indicating the multilayer adsorption process on heterogeneous surfaces and interactions between adsorbate molecules. The results from other isotherm models also confirmed that the adsorption process occurs physically via Van der Waals force in binding adsorbate on the surface of adsorbent.
Managing COVID-19 With a Clinical Decision Support Tool in a Community Health Network: Algorithm Development and Validation (Preprint)
Authors: McRae Michael P , Dapkins Isaac P , Sharif Iman , Anderman Judd , Fenyo David , Sinokrot Odai , Kang Stella K , Christodoulides Nicolaos J , Vurmaz Deniz , Simmons Glennon W , Alcorn Timothy M. , Daoura Marco J , Gisburne Stu , Zar David , McDevitt John T
Published: July 2020

BACKGROUND

The coronavirus disease (COVID-19) pandemic has resulted in significant morbidity and mortality; large numbers of patients require intensive care, which is placing strain on health care systems worldwide. There is an urgent need for a COVID-19 disease severity assessment that can assist in patient triage and resource allocation for patients at risk for severe disease.

OBJECTIVE

The goal of this study was to develop, validate, and scale a clinical decision support system and mobile app to assist in COVID-19 severity assessment, management, and care.

METHODS

Model training data from 701 patients with COVID-19 were collected across practices within the Family Health Centers network at New York University Langone Health. A two-tiered model was developed. Tier 1 uses easily available, nonlaboratory data to help determine whether biomarker-based testing and/or hospitalization is necessary. Tier 2 predicts the probability of mortality using biomarker measurements (C-reactive protein, procalcitonin, D-dimer) and age. Both the Tier 1 and Tier 2 models were validated using two external datasets from hospitals in Wuhan, China, comprising 160 and 375 patients, respectively.

RESULTS

All biomarkers were measured at significantly higher levels in patients who died vs those who were not hospitalized or discharged (P<.001). The Tier 1 and Tier 2 internal validations had areas under the curve (AUCs) of 0.79 (95% CI 0.74-0.84) and 0.95 (95% CI 0.92-0.98), respectively. The Tier 1 and Tier 2 external validations had AUCs of 0.79 (95% CI 0.74-0.84) and 0.97 (95% CI 0.95-0.99), respectively.

CONCLUSIONS

Our results demonstrate the validity of the clinical decision support system and mobile app, which are now ready to assist health care providers in making evidence-based decisions when managing COVID-19 patient care. The deployment of these new capabilities has potential for immediate impact in community clinics and sites, where application of these tools could lead to improvements in patient outcomes and cost containment.
Association Between Public Knowledge About COVID-19, Trust in Information Sources, and Adherence to Social Distancing: Cross-Sectional Survey (Preprint)
Authors: Fridman Ilona , Lucas Nicole , Henke Debra , Zigler Christina K
Published: July 2020

BACKGROUND

The success of behavioral interventions and policies designed to reduce the impact of the COVID-19 pandemic depends on how well individuals are informed about both the consequences of infection and the steps that should be taken to reduce the impact of the disease.

OBJECTIVE

The aim of this study was to investigate associations between public knowledge about COVID-19, adherence to social distancing, and public trust in government information sources (eg, the US Centers for Disease Control and Prevention), private sources (eg, FOX and CNN), and social networks (eg, Facebook and Twitter) to inform future policies related to critical information distribution.

METHODS

We conducted a cross-sectional survey (N=1243) between April 10 and 14, 2020. Data collection was stratified by US region and other demographics to ensure representativeness of the sample.

RESULTS

Government information sources were the most trusted among the public. However, we observed trends in the data that suggested variations in trust by age and gender. White and older populations generally expressed higher trust in government sources, while non-White and younger populations expressed higher trust in private sources (eg, CNN) and social networks (eg, Twitter). Trust in government sources was positively associated with accurate knowledge about COVID-19 and adherence to social distancing. However, trust in private sources (eg, FOX and CNN) was negatively associated with knowledge about COVID-19. Similarly, trust in social networks (eg, Facebook and Twitter) was negatively associated with both knowledge and adherence to social distancing.

CONCLUSIONS

During pandemics such as the COVID-19 outbreak, policy makers should carefully consider the quality of information disseminated through private sources and social networks. Furthermore, when disseminating urgent health information, a variety of information sources should be used to ensure that diverse populations have timely access to critical knowledge.
APOL1 Nephropathy: From Genetics to Clinical Applications
Authors: Friedman David J. , Pollak Martin R.
Published: July 2020

Rates of many types of severe kidney disease are much higher in Black individuals than most other ethnic groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated nephropathy, and other forms of nondiabetic kidney disease. We discuss the population genetics of APOL1 risk variants and the clinical spectrum of APOL1 nephropathy. We then consider clinical issues that arise for the practicing nephrologist caring for the patient who may have APOL1 kidney disease.
Disyunciones: salidas de la "normalidad"
Authors: Millán Moncayo Márgara
Published: July 2020

En este ensayo se interpela el flujo de la “normalidad” a través del advenimiento de la discapacidad, la cual se nos puede presentar como una ventana para tomar distancia y comprender fundamentos de las relaciones humanas que no siempre son evidentes y que son contravenidos por la realidad productivista e instrumental en la que vivimos. Así, la diferencia se puede posicionar como una ocasión de aprendizaje, en un proyecto de humanidad posible, crítico al presente. Se explora desde ciertas experiencias de la discapacidad el continente teórico que sociológicamente le compete, entendiendo el juego de las representaciones y categorizaciones sociales como barreras que segregan al ordenar el texto social. Combinando referencias vivenciales con referencias teóricas se presenta un territorio transdisciplinario desde el cuál poder construir una “sociedad inclusiva”.