bluuebunny/crossref_metadata_2025 huggingface dataset:
On the record of vertebral deformities in Mastacembelus mastacembelus collected from the lower reaches of Euphrates River, Iraq
Authors: JAWAD Laith , MUTLAK Falah , AL-FAISAL Abbas
Published: June 2016

Severe deformity such as coalescence of vertebrae, compact vertebrae, loss of vertebral parts, and different levels of deformed vertebral centra and minor deformities such as undulation of the haemal spines of the vertebrae are reported in six specimens of Mastacembelus mastacembelus(Family: Mastacembelidae) collected from the lower reaches of Euphrates River, at Nasiria marsh area, Iraq. Several abdominal and caudal vertebrae are involved in this anomaly. Possible causes such as genetic and epigenetic factors may be implicated in this anomaly.
Length-weight relationships of 29 species of teleost fish from shallow estuarine environment of Samborombon Bay (Rí­­o De la Plata, Argentina)
Authors: SOLARI Agustín , JAUREGUIZAR Andrés Javier , MILESSI Andrés Conrado , GARCÍA Mirta Lidia , MAIZTEGUI Tomás
Published: June 2016

The lengthí weight relationships (LWR) of 29 teleost fish species from the shallow estuarine environments of the Samborombón Bay wetland (Rí­­o de la Plata, Argentina) were estimated. A total of 6,376 individuals belonging to 19 families were measured and weighed. The best represented family was Sciaenidae with 6 species, followed by Clupeidae (n = 3), and Heptapteridae and Characidae with 2 species each. Significant lengthí weight relationships with high correlation coefficients were found for all species, which mostly presented positive allometric growth. This study reports the first findings regarding the LWR of 29 species in the Samborombón Bay waters. New maximum sizes and geographic distribution records of certain species are also commented.
Determinação de í­­ndices morfométricos que favorecem o rendimento industrial de filés de tilápia (Oreochromis niloticus)
Authors: SILVA Lena Magalhães da , SAVAY-DA-SILVA Luciana Kimie , ABREU Joadil Gonçalves de , FIGUEIREDO Eduardo Eustáquio de Souza
Published: June 2016

Objetivou-se determinar a melhor faixa de peso e caracterí­­sticas morfometrias que favorecem o rendimento do filé de tilápia em escala industrial. O delineamento experimental foi inteiramente casualizado (3 tratamentos (350í 550 g; 551í 750 g; 751í 10) e 15 repetições). Os dados foram submetidos í­Â  análise de varií­¢ncia (ANOVA) e teste de Tukey ao ní­­vel de 5% de probabilidade. Os valores médios de altura dos peixes variaram de 8,9 a 12,6 cm, comprimento de 27,8 a 37,1 cm, espessura dos lombos de 3,9 a 4,2 mm e rendimentos dos filés de 27 a 28,6%. Houve diferenças estatí­­sticas em relação a altura, comprimento e espessura do lombo entre as faixas de peso. Na condição avaliada, os parí­¢metros para obtenção de maior rendimento de filé na indústria seriam tilápias ao abate na faixa de peso 551í 750g, com médias de 31,2 cm de comprimento e 4,2 mm de espessura de lombo.
Colapso do estoque de Umbrina canosai do Sul do Brasil devido í­Â introdução do arrasto-de-meia-água
Authors: HAIMOVICI Manuel , CARDOSO Luís Gustavo
Published: June 2016

Recentemente o uso do arrasto-de-meia-água com equipamentos como sonares e sondas de rede tornou possí­­vel a captura de cardumes de castanha Umbrina canosai maturas e em desova que migram em direção ao norte próximo ao fundo, ao longo da plataforma externa do sul do Brasil anualmente entre o fim do outono e primavera. Os rendimentos de 2011 e 2012 foram excepcionais, 11.805 kg/dia chegando a 20.000 kg/dia quase exclusivos de castanhas, quatro vezes maiores do que os dos mais de 300 barcos de arrasto-de-parelha e emalhe-de-fundo que tem como alvo principal a castanha. O número crescente de arrasteiros de meia água, somado í­Â  intensa exploração dos últimos 40 anos, alerta sobre o forte risco de colapso da segunda espécie em importí­¢ncia na pesca demersal da região. O colapso de pescarias com a introdução de técnicas que aumentam o poder de pesca não são novidade no sul do Brasil.
Explant Analysis from a Patient Exhibiting Rapid Acceleration of Parkinson Disease Symptoms and Hypercobaltemia Following Metal-on-Metal Total Hip Arthroplasty
Authors: Woelber Erik , Van Citters Douglas W. , Steck Thomas , Glass Graham Alec , Tower Stephen
Published: June 2016

Case:

A 46-year-old man developed rapidly progressing Parkinson disease symptoms after metal-on-metal total hip arthroplasty, worsening to the extent that he underwent implantation of a right subthalamic deep brain stimulator (DBS). A serum cobalt level of 116 μg/L was measured shortly after DBS implantation, and revision arthroplasty was performed using ceramic-on-polyethylene bearings. After revision, the patient’s serum cobalt level fell below 1 μg/L, the Parkinson disease symptoms improved, and he reduced the DBS to its lowest setting. Explant analysis showed substantial material loss from the bearing surfaces of one hip.

Conclusion:

Future studies should evaluate the possible link between Parkinson disease symptoms and prosthesis wear-induced hypercobaltemia.
DESIGN AND IMPLEMENTATION OF A WIRELESS NETWORK SYSTEM IN A SMART CAMPUS
Authors: Anwar Toni , Mui Wendy Goh Pek
Published: June 2016

Article talks about the design and implementation of wireless network in Engineering Campus of UniversitySains Malaysia. The goals of this research is designing a network which able to bring mobility to all network usersin this campus. In this research, there is a mathematical model which can be used to predict the coverage of theaccess point. Coverage testing had been carried out at library. Based on the original placement of the access pointwhich done by the PPKT, the Universiti Sains Malaysia’s (USM) computer center. Since the result is not so satisfying,a new design based on the characteristic of the access point and the building structure was done.Keywords: wireless network, smart campus, library
SISTEM PAKAR: DIAGNOSIS PENYAKIT UNGGAS DENGAN METODE CERTAINTY FACTOR
Authors: Rohajawati Siti , Supriyati Rina
Published: June 2016

The development of expert systems–based applications has been very popular since 1950, with a rather wide coverage. Expert systems in organizations are aimed at adding value, increasing productivity and assisting management to take quick decisions. Similarly, organization engaging in the farming industry, while very promising, requires high awareness against diseases, such as poultry (chicken) which are very susceptible to various types of diseases caused by viruses or bacteria. Benefits of implementing the expert system are that they can diagnose the symptoms of diseases quickly and accurately and they are expected to be able to help farmers in anticipating the losses resulting from disease attack. Accurate and precise calculations are required to diagnose symptoms in order to conclude the output by means of the Certainty Factors (CFs)Keywords: expert system, diagnosing the diseases, method of Certainty Factors (CFs)
PENGEMBANGAN CUSTOMER RELATIONSHIP MANAGEMENT BERBASIS SISTEM E-COMMERCE
Authors: Montana Sugiarto , Noor Muwasiq Mochamad
Published: June 2016

PT Dwisanjaya Abadi Mukti is a company engaged in distributing Pertamina lubricating agent with products for industrial and automotive lubricants. Therefore, companies need a Customer Relationship Management E-commerce-based systems, to address the issues of purchasing and service to customers that are still conducted manually. Systems analysis is done through observation interviews, and literature; analysis of survey findings; and identification of information needs from survey. The system is designed to give advantage to the user as to obtain the desired information quickly, to acquire new customers, improve customer relationships, and retain customers; other than that for the company this system reduces operating costs, more efficient time, accessible anytime and anywhere, improving work productivity, increase sales, increase the number of customers, and improve customer satisfaction.Keywords: customer relationship management, e-commerce, front end, back end
DEVELOPMENT MODEL FOR SUPPORTING THE ACCOMPLISHMENT OF ACADEMIC LEVEL: CASE STUDY OF BINA NUSANTARA UNIVERSITY
Authors: Heripracoyo Sulistyo , Saputra Wawan , Wince Wince
Published: June 2016

The fact that a small number of lecturers who are able to meet or pass the requirementsfor obtaining or enhancing the academic hierarchy (JJA/Jenjang Jabatan Akademis) is the reasonof the study. An analysis was performed on the historical data of the university faculty members.Analysis of historical data was done by making use of a data warehouse and data miningapplications to describe and map lecturer’s JJA care, as well as with the data mining tool WEKAversion 3.6.6. to know some of the variables that affect the maintenance of the JJA at BinaNusantara University. Results of this study are most between the ages of 30 and 45 years old, andfor analysis based on a paper having an excellent outcome is the level of lecturer (Lektor) andAssociate Professor. Based on these results, it needs special attention especially those agedbetween 30 and 45 and who have JJA Associate Professor and Lecturer (Lektor).
INFORMATION SYSTEM STRATEGIC PLANNING WITH ENTERPRISE ARCHITECTURE PLANNING
Authors: Astri Lola Yorita , Gaol Ford Lumban
Published: June 2016

An integrated information system is needed in an enterprise to support businessprocesses run by an enterprise. Therefore, to develop information system can use enterprisearchitecture approach which can define strategic planning of enterprise information system. SMPNegeri 1 Jambi can be viewed as an enterprise because there are entities that should be managedthrough an integrated information system. Since there has been no unification of different elementsin a unity yet, enterprise architecture model using Enterprise Architecture Planning (EAP) isneeded which will obtain strategic planning of enterprise information system in SMP Negeri 1Jambi. The goal of strategic planning of information system with Enterprise Architecture Planning(EAP) is to define primary activities run by SMP Negeri 1 Jambi and support activities supportingprimary activities. They can be used as a basis for making data architecture which is the entities ofapplication architecture. At last, technology architecture is designed to describe technology neededto provide environment for data application. The plan of implementation is the activity plan madeto implemented architectures by enterprise.
WEB APPLICATION SURVEY PERFORMANCE EVALUATION PT. KALBE MORINAGA INDONESIA
Authors: Sudarma Hantze , Wahjono Tri Djoko
Published: June 2016

Research on this case study aims to evaluate the web application survey PT. KalbeMorinaga Indonesia. This case study was done because of some performance issue on theapplication. The problems related to the ability of software to speed data processing and reporting.Research was done on the performance of software and was combined using the gray box, that is,the evaluation of the test and evaluation of the code of the network itself. In addition, it was usedfor testing software for test automation. Automation tests were done as much as several times witha different number of virtual users. Results obtained were analyzed so as to be used as a referencefor the results which pages have problems with performance issues, and were tested by using asolution which then were tested again on that page and comparing the results. The final results ofthe analysis were compared with the results of the first test and then the results of the analysis andrecommendations for improvement can be used by application developers in the future.
THE EFFECT OF LECTURER’S PROFESSIONALISM AND STUDENT’S STUDY INTEREST AND MOTIVATION ON ACADEMIC ACHIEVEMENT OF BACHELOR DEGREE STUDENT IN ONLINE LEARNING IN BINUS UNIVERSITY
Authors: Trivena Trivena , Harisno Harisno
Published: June 2016

Online learning is a learning method that doesn’t close any possibility can be run with collaboration between learning asynchronous and synchronous model. This research is to find out whether lecturer’s professionalism and student’s interest and study motivation give significant effect to academic achievement of bachelor degree online learning in BINUS university either concurrent or partial. Sampling technique that is used is random sampling, and used sample is about 99 samples of active student. Hypothesis testing that is done using one lane analysis model, where analysis is done using regression analysis test and corelation analysis test either concurrent or partial. The result of this research can be concluded that there is significant effect between lecturer’s professionalism, student’s interest and motivation with student’s academic achievement either partial or concurrent. This research result is hoped to be able to give benefit to BINUS University, so it can be suggestion in developing teaching and learning system in BINUS online learning by paying attention to external and internal factors that affect and increase student’s academic achievement.
DEVELOPMENT OF CUSTOMER RELATIONSHIP MANAGEMENT SYSTEM TO IMPROVE SERVICE QUALITY IN PT MANULIFE LIFE INSURANCE INDONESIA
Authors: Chriswanto Chriswanto
Published: June 2016

Customer Relationship Management System (CRMS) Development in order to improve service quality in PT. AJ. Manulife Indonesia is done by comprehending the performance model of the company and the factors that are affecting the company performance improvement and the quality of the decision to be taken by top management. System Dynamic is a method that can be used to stimulate complex systems. System Dynamics approach is expected to build a model of corporate performance that can be used to evaluate the quality of service to customers so that they can make decisions quickly and accurately. This study proves that the model is built with standard models used as changing targets and it can simulate a target quality of service to customers by delivering current and future achievement. Achievement in the future is influenced by the value of achievement of SLA, Response Time, and Defect, where the greater value of control, the greater value of the correction rate so that the GAP will be smaller. Correction rate which is determined in this study was 10%, 20%, and 30% of GAP (CB)
The Determinants of New Product Performance in Malaysian Industry
Authors: Fok-Yew Oon
Published: June 2016

The literature on new product development is growing but Malaysia manufacturing industry often lacks these discussions. Therefore, this paper focuses on linking the determinants of an effective product development process and new product performance within manufacturing companies across industries in Malaysia that have certain level of new product development activities taking in their organization. Further, the paper organises the burgeoning new product development literature into four main determinants: customer orientation, cross-functional team, new product development team proficiency and management support. The selection of determinants to the theoretical framework is adjusting for manufacturing industry origins in previous written research material. The literature review focuses on the product development process and builds the framework of conceptual model detailing the initialization and implementation stage in the product development process. Two theoretical perspectives have guided the conceptual framework which is the resource-based view and organizational theories. The proposal is to give an increased understanding of the changed new product process in Malaysian industry and its implication on activities concerning organisation and management of the new product development process. This framework reflects a growing interest in extending new product development paradigms to emerging in ASEAN countries, thus contributing to a wider body of knowledge.
A Spatial Analysis on International Remittances, Food Consumption and Deprivation in Indonesia
Authors: Elfani Maria
Published: June 2016

This paper aims to illustrate how international remittances may relate to food consumption and deprivation in Indonesia. The idea is that international remittances may contribute to the reduction of poverty, and since food consumption is an element with which to measure poverty line, this paper intends to show whether international remittances are more likely to be received by poorer households–based on food consumption level in the households. Using Geographic Information Systems (GIS) and the data from the Indonesia Family Life Survey (IFLS4), this paper illustrates the mapping of international remittances and food consumption in some of Indonesia’s provinces. The spatial analysis shows correlation between international remittances and food consumption. International remittances tend to be received by households who have less spending on food. The geographical pattern shows that international remittances are more likely to be received by poorer households based on their food consumption. The result to some extent supports the view that international remittances might benefit the poor the most, particularly on tackling poverty, as poorer households are more likely to receive the remittances.
Indonesia Rejoining OPEC: Dynamics of the Oil Importer and Exporter Countries
Authors: Badaruddin Muhammad
Published: June 2016

Reactivation of Indonesia’s full membership to the Organization of the Petroleum Exporting Countries (OPEC) triggered discussion surrounding global petroleum governance. The country which decided to suspend its full membership at the end of 2008, currently labelled as net oil importer. However, in OPEC terms Indonesia never really left, instead of the organization termed it as a "suspension”. Departing from the abovementioned context and perspectives, purpose of this essay is to answer the questions about the significance of the Indonesia’s membership reactivation to OPEC, and the strategic context of the reactivation in the current global oil market. In answering these questions, this article draws the dynamics of the relation of Indonesia and OPEC through the history in the first part and explores Indonesia’s interests in rejoining OPEC in the second one. In the third part, this essay will explore the possible benefit for OPEC as an organization as well as for its member countries could achieve by approving Indonesia’s request to reactivate its membership, despite its status as a net oil importer.
Water dynamics and groundwater recharge in a deep vadose zone
Authors: Ju Zhaoqiang , Li Xiaoxin , Hu Chunsheng
Published: June 2016

Understanding soil water dynamics and accurately estimating groundwater recharge are essential steps in achieving efficient and sustainable management of groundwater resources in regions with deep vadose zones. The objective of this study was to understand transient data and the dynamics nature of water from deep sections at the thick vadose zone, and to estimate groundwater recharge by applying Darcy's law of unsaturated water fluxes. The study was conducted during year 2009–2013 at Luancheng Agro-ecosystem Experimental Station of Chinese Academy of Sciences, which is located in the North China Plain. The water contents were measured with water probes and matric suctions using pressure transducers at depths of 9 and 11 m and were combined with laboratory measurements of unsaturated hydraulic conductivity to estimate groundwater recharge. The results indicated that the soil water content at 9- and 11-m depths increased following the rainy season and then gradually stabilized. And the intensity and continuity of precipitation events played an important role in soil water changes. The soil water dynamics between different depths (9 and 11 m) indicated a time lag (approximately 5–11 days). The groundwater recharge ranged from 7.60 to 19.75 mm resulting from hysteresis over the study period.
Tissue responses resulting from tooth movement surgically assisted by corticotomy and corticision in rats
Authors: Peron Ana Paula Lazzari Marques , Johann Aline Cristina Batista Rodrigues , Papalexiou Vula , Tanaka Orlando Motohiro , Guariza-Filho Odilon , Ignácio Sergio Aparecido , Camargo Elisa Souza
Published: June 2016

Objective: To compare the histological responses in corticotomy- and corticision-assisted tooth movement.

Materials and Methods: Ninety Wistar rats were divided into three groups: C (control—tooth movement only), CT (tooth movement + corticotomy), and CI (tooth movement + corticision). Surgeries were performed on the vestibular and lingual cortical bone of the maxillary first molar. Tooth movement was carried out with nickel-titanium closed coil springs having a force of 30 g. The rats were sacrificed at 3, 14, and 28 days. To evaluate the number of osteoclasts and amount of root resorption, a tartrate-resistant acid phosphatase stain was used. Hematoxylin and eosin staining was performed for areas of hyalinization, and the organic bone matrix was stained with picrosirius.

Results: The CT group showed a greater number of osteoclasts than did the C group on day 3 (P < .05). At the same time point, the CT and CI groups showed a delayed onset of organic bone matrix remodeling and a lower incidence of root resorption than did the C group (P < .05). There were also fewer hyalinization areas in the CI group than in the C group on day 3 (P < .05).

Conclusions: Corticotomy effectively increased bone resorption during the early stages of tooth movement, but this increase was not observed for corticision. The surgical procedures did not accelerate organic bone matrix remodeling. Corticotomies and corticisions decreased the risk of root resorption only during the early stages of movement. Corticision reduced the level of hyalinization, while corticotomy did not.
GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects
Authors: Moraes-Vieira Pedro M. , Saghatelian Alan , Kahn Barbara B.
Published: June 2016

Adipose tissue (AT) regulates systemic insulin sensitivity through multiple mechanisms, and alterations in de novo lipogenesis appear to contribute. Mice overexpressing GLUT4 in adipocytes (AG4OX) have elevated AT lipogenesis and enhanced glucose tolerance despite being obese and having elevated circulating fatty acids. Lipidomic analysis of AT identified a structurally unique class of lipids, branched fatty acid esters of hydroxy–fatty acids (FAHFAs), which were elevated in AT and serum of AG4OX mice. Palmitic acid esters of hydroxy–stearic acids (PAHSAs) are among the most upregulated FAHFA families in AG4OX mice. Eight PAHSA isomers are present in mouse and human tissues. PAHSA levels are reduced in insulin resistant people, and levels correlate highly with insulin sensitivity. PAHSAs have beneficial metabolic effects. Treatment of obese mice with PAHSAs lowers glycemia and improves glucose tolerance while stimulating glucagon-like peptide 1 and insulin secretion. PAHSAs also reduce inflammatory cytokine production from immune cells and ameliorate adipose inflammation in obesity. PAHSA isomer concentrations are altered in physiological and pathophysiological conditions in a tissue- and isomer-specific manner. The mechanisms most likely involve changes in PAHSA biosynthesis, degradation, and secretion. The discovery of PAHSAs reveals the existence of previously unknown endogenous lipids and biochemical pathways involved in metabolism and inflammation, two fundamental physiological processes.
Use of Perturbation-Based Gait Training in a Virtual Environment to Address Mediolateral Instability in an Individual With Unilateral Transfemoral Amputation
Authors: Sheehan Riley C. , Rábago Christopher A. , Rylander Jonathan H. , Dingwell Jonathan B. , Wilken Jason M.
Published: June 2016

Background and Purpose

Roughly 50% of individuals with lower limb amputation report a fear of falling and fall at least once a year. Perturbation-based gait training and the use of virtual environments have been shown independently to be effective at improving walking stability in patient populations. An intervention was developed combining the strengths of the 2 paradigms utilizing continuous, walking surface angle oscillations within a virtual environment. This case report describes walking function and mediolateral stability outcomes of an individual with a unilateral transfemoral amputation following a novel perturbation-based gait training intervention in a virtual environment.

Case Description

The patient was a 43-year-old male veteran who underwent a right transfemoral amputation 7+ years previously as a result of a traumatic blast injury. He used a microprocessor-controlled knee and an energy storage and return foot.

Outcomes

Following the intervention, multiple measures indicated improved function and stability, including faster self-selected walking speed and reduced functional stepping time, mean step width, and step width variability. These changes were seen during normal level walking and mediolateral visual field or platform perturbations. In addition, benefits were retained at least 5 weeks after the final training session.

Discussion

The perturbation-based gait training program in the virtual environment resulted in the patient's improved walking function and mediolateral stability. Although the patient had completed intensive rehabilitation following injury and was fully independent, the intervention still induced notable improvements to mediolateral stability. Thus, perturbation-based gait training in challenging simulated environments shows promise for improving walking stability and may be beneficial when integrated into a rehabilitation program.
Survival and Risk Comparison of Campylobacter jejuni on Various Processed Meat Products
Authors: Hong Soo , Kim Han , Yoon Ki
Published: June 2016

The objective of this study was to investigate survival kinetics of Campylobacter jejuni on various processed meat products (dry-cured ham, round ham with/without sodium nitrite, garlic seasoned ham with/without sodium nitrite, and sausage without sodium nitrite). Additionally, a semi-quantitative risk assessment of C. jejuni on various processed meat products was conducted using FDA-iRISK 1.0. Inoculated processed meat products with 6.0 ± 0.5 log CFU/g of C. jejuni were vacuum packed and stored at 4, 10, 17, 24, 30, and 36 °C. Survival curves were fitted to the Weibull model to obtain the delta values of C. jejuni on various processed meat products. The most rapid death of C. jejuni was observed on dry-cured ham, followed by sausage without sodium nitrite. The results of semi-quantitative risk assessment indicate that dry-cured ham represented the lowest risk among all samples. C. jejuni on processed meats presented a greater risk at 4 °C than at 10 °C. The risk of ham was greater than the risk of sausage, regardless of type. Among all samples, the highest risk of C. jejuni was observed in round ham without sodium nitrite. Overall, our data indicates that risk of processed meat products due to C. jejuni is relatively low.
Protective Effect of Ginsenoside Rg1 on Hematopoietic Stem/Progenitor Cells through Attenuating Oxidative Stress and the Wnt/β-Catenin Signaling Pathway in a Mouse Model of d-Galactose-induced Aging
Authors: Li Jing , Cai Dachuan , Yao Xin , Zhang Yanyan , Chen Linbo , Jing Pengwei , Wang Lu , Wang Yaping
Published: June 2016

Stem cell senescence is an important and current hypothesis accounting for organismal aging, especially the hematopoietic stem cell (HSC). Ginsenoside Rg1 is the main active pharmaceutical ingredient of ginseng, which is a traditional Chinese medicine. This study explored the protective effect of ginsenoside Rg1 on Sca-1+ hematopoietic stem/progenitor cells (HSC/HPCs) in a mouse model of d-galactose-induced aging. The mimetic aging mouse model was induced by continuous injection of d-gal for 42 days, and the C57BL/6 mice were respectively treated with ginsenoside Rg1, Vitamin E or normal saline after 7 days of d-gal injection. Compared with those in the d-gal administration alone group, ginsenoside Rg1 protected Sca-1+ HSC/HPCs by decreasing SA-β-Gal and enhancing the colony forming unit-mixture (CFU-Mix), and adjusting oxidative stress indices like reactive oxygen species (ROS), total anti-oxidant (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-px) and malondialdehyde (MDA). In addition, ginsenoside Rg1 decreased β-catenin and c-Myc mRNA expression and enhanced the phosphorylation of GSK-3β. Moreover, ginsenoside Rg1 down-regulated advanced glycation end products (AGEs), 4-hydroxynonenal (4-HNE), phospho-histone H2A.X (r-H2A.X), 8-OHdG, p16Ink4a, Rb, p21Cip1/Waf1 and p53 in senescent Sca-1+ HSC/HPCs. Our findings indicated that ginsenoside Rg1 can improve the resistance of Sca-1+ HSC/HPCs in a mouse model of d-galactose-induced aging through the suppression of oxidative stress and excessive activation of the Wnt/β-catenin signaling pathway, and reduction of DNA damage response, p16Ink4a-Rb and p53-p21Cip1/Waf1 signaling.
Studies to Prevent Degradation of Recombinant Fc-Fusion Protein Expressed in Mammalian Cell Line and Protein Characterization
Authors: Chakrabarti Sanjukta , Barrow Colin , Kanwar Rupinder , Ramana Venkata , Kanwar Jagat
Published: June 2016

Clipping of recombinant proteins is a major issue in animal cell cultures. A recombinant Fc-fusion protein, VEGFR1(D1–D3)-Fc expressed in CHOK1SV GS-KO cells was observed to be undergoing clippings in lab scale cultures. Partial cleaving of expressed protein initiated early on in cell culture and was observed to increase over time in culture and also on storage. In this study, a few parameters were explored in a bid to inhibit clipping in the fusion protein The effects of culture temperature, duration of culture, the addition of an anti-clumping agent, ferric citrate and use of protease inhibitor cocktail on inhibition of proteolysis of the Fc fusion were studied. Lowering of culture temperature from 37 to 30 °C alone appears to be the best solution for reducing protein degradation from the quality, cost and regulatory points of view. The obtained Fc protein was characterized and found to be in its stable folded state, exhibiting a high affinity for its ligand and also biological and functional activities.
The Interactions of CPP–ACP with Saliva
Authors: Huq Noorjahan , Myroforidis Helen , Cross Keith , Stanton David , Veith Paul , Ward Brent , Reynolds Eric
Published: June 2016

The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on casein phosphopeptide-stabilised amorphous calcium phosphate complexes (CPP–ACP). These complexes consist of an amorphous calcium phosphate mineral phase stabilised and encapsulated by the self-assembly of milk-derived phosphopeptides. During topical application of CPP–ACP complexes in the oral cavity, the CPP encounters the enamel pellicle consisting of salivary proteins and peptides. However the interactions of the CPP with the enamel salivary pellicle are not known. The studies presented here reveal that the predominant peptides of CPP–ACP complexes do interact with specific salivary proteins and peptides of the enamel pellicle, and provide a mechanism by which the CPP–ACP complexes are localised at the tooth surface to promote remineralisation.
Designing a Situational Awareness Information Display: Adopting an Affordance-Based Framework to Amplify User Experience in Environmental Interaction Design
Authors: Chen Yingjie , Qian Zhenyu , Lei Weiran
Published: June 2016

User experience remains a crucial consideration when assessing the successfulness of information visualization systems. The theory of affordances provides a robust framework for user experience design. In this article, we demonstrate a design case that employs an affordance-based framework and evaluate the information visualization display design. SolarWheels is an interactive information visualization designed for large display walls in computer network control rooms to help cybersecurity analysts become aware of network status and emerging issues. Given the critical nature of this context, the status and performance of a computer network must be precisely monitored and remedied in real time. In this study, we consider various aspects of affordances in order to amplify the user experience via visualization and interaction design. SolarWheels visualizes the multilayer multidimensional computer network issues with a series of integrated circular visualizations inspired by the metaphor of the solar system. To amplify user interaction and experience, the system provides a three-zone physical interaction that allows multiple users to interact with the system. Users can read details at different levels depending on their distance from the display. An expert evaluation study, based on a four-layer affordance framework, was conducted to assess and improve the interactive visualization design.
Further Screening of Entomopathogenic Fungi and Nematodes as Control Agents for Drosophila suzukii
Authors: Cuthbertson Andrew , Audsley Neil
Published: June 2016

Drosophila suzukii populations remain low in the UK. To date, there have been no reports of widespread damage. Previous research demonstrated that various species of entomopathogenic fungi and nematodes could potentially suppress D. suzukii population development under laboratory trials. However, none of the given species was concluded to be specifically efficient in suppressing D. suzukii. Therefore, there is a need to screen further species to determine their efficacy. The following entomopathogenic agents were evaluated for their potential to act as control agents for D. suzukii: Metarhizium anisopliae; Isaria fumosorosea; a non-commercial coded fungal product (Coded B); Steinernema feltiae, S. carpocapsae, S. kraussei and Heterorhabditis bacteriophora. The fungi were screened for efficacy against the fly on fruit while the nematodes were evaluated for the potential to be applied as soil drenches targeting larvae and pupal life-stages. All three fungi species screened reduced D. suzukii populations developing from infested berries. Isaria fumosorosea significantly (p < 0.001) reduced population development of D. suzukii from infested berries. All nematodes significantly reduced adult emergence from pupal cases compared to the water control. Larvae proved more susceptible to nematode infection. Heterorhabditis bacteriophora proved the best from the four nematodes investigated; readily emerging from punctured larvae and causing 95% mortality. The potential of the entomopathogens to suppress D. suzukii populations is discussed.
Challenges in Analyzing the Biological Effects of Resveratrol
Authors: Erdogan Cihan , Vang Ole
Published: June 2016

The suggested health effects (e.g., disease prevention) of dietary bioactive compounds such as resveratrol are challenging to prove in comparison to man-made drugs developed for therapeutic purposes. Dietary bioactive compounds have multiple cellular targets and therefore have a variety of biological effects. Extrapolating the biological effects of dietary compounds from in vitro and in vivo animal experiments to humans may lead to over- or under-estimation of the effect and role of these compounds. The present paper will discuss a few of these challenges and suggest directions for future research. Questions we address include: (1) Is the combinatorial effect of resveratrol and other compounds real? (2) What are the real and relevant doses of resveratrol after administration? and (3) Is it possible to estimate the preventive effect of resveratrol by clinical trials using standard experimental designs? The examples concerning resveratrol taken from the scientific literature are mainly from 2010 and later. The challenges pointed out in this review are similar to most naturally occurring bioactive compounds.
Physical Layer Security Using Two-Path Successive Relaying
Authors: Liau Qian , Leow Chee , Ding Zhiguo
Published: June 2016

Relaying is one of the useful techniques to enhance wireless physical-layer security. Existing literature shows that employing full-duplex relay instead of conventional half-duplex relay improves secrecy capacity and secrecy outage probability, but this is at the price of sophisticated implementation. As an alternative, two-path successive relaying has been proposed to emulate operation of full-duplex relay by scheduling a pair of half-duplex relays to assist the source transmission alternately. However, the performance of two-path successive relaying in secrecy communication remains unexplored. This paper proposes a secrecy two-path successive relaying protocol for a scenario with one source, one destination and two half-duplex relays. The relays operate alternately in a time division mode to forward messages continuously from source to destination in the presence of an eavesdropper. Analytical results reveal that the use of two half-duplex relays in the proposed scheme contributes towards a quadratically lower probability of interception compared to full-duplex relaying. Numerical simulations show that the proposed protocol achieves the ergodic achievable secrecy rate of full-duplex relaying while delivering the lowest probability of interception and secrecy outage probability compared to the existing half duplex relaying, full duplex relaying and full duplex jamming schemes.
China’s Energy Intensity, Determinants and Spatial Effects
Authors: Jiang Lei , Ji Minhe
Published: June 2016

In the shadow of the energy crisis and environmental degradation, energy intensity is a hot topic in academic circles in China. The energy intensity distribution map of China indicates the fairly large geographic disparities globally and clustering locally in some areas, ascending from the southeast regions to the northwest provinces. Although energy intensity and its determinants vary from place to place, few studies have been made from the spatial perspective. Determinates of energy intensity and spatial spillover effects should be taken into consideration. Controlling for seven exogenous variables (per capita GDP; the share of the secondary sector; foreign direct investment; international trade, energy price, the share of coal, and transport sector) and their spatial lags, we apply a spatial Durbin model to test for spatial spillover effects among energy intensity and exogenous variables from a panel of 29 Chinese provinces over 1998 to 2014. We find that per capita GDP has an insignificant and negative direct and indirect effect, but has a significant and negative total effect on energy intensity. The share of the secondary sector and the share of coal are found to have significant and positive direct and indirect effects on energy intensity. Foreign Direct Investment (FDI) and Trade have significant and negative direct and indirect effects on energy intensity. The direct effect of energy price is found to be significantly positive while the indirect effect is negative. Only the direct effect of the Transport variable is significant and positive. The results of this study offer some theoretical evidence for differential localized policy making related to reduction in energy intensity.
Du bâtiment au quartier : innovation et développement durable (From buildings to neighborhoods : innovation and sustainable development)
Authors: Bertrand Vincent
Published: June 2016

Housing environment and town planning are one of the most important stakes in sustainable development. New logics are born and generate an increasing number of innovations. PassivHaus, Ecosquare ® and sustainable «village-rue » are three examples presented here to better comprehend the socioeconomic, territorial and political stakes bound to these innovations.
La passion des images
Authors: Schlegel Jean-Louis
Published: June 2016

L’interdit des représentations puise aux sources platonicienne, juive et musulmane pour distinguer le visible dégradé et l’invisible idéal. Si l’incarnation autorise les images, l’histoire du christianisme est secouée de crises iconoclastes. Ces tensions n’ont pas disparu de nos sociétés séculières et pleines d’images.
L’imagination face à l’irreprésentable. À propos de Moïse et Aaron
Authors: Mongin Olivier
Published: June 2016

L’opéra de Schönberg interroge le rôle de l’imagination : pour éviter l’idolâtrie, faut-il renoncer à communiquer l’invisible ? Il est possible de suivre l’invitation de Ricœur à penser l’imagination comme reconfiguration du monde.
Sexe, limites et censure au cinéma
Authors: Andrieu Louis
Published: June 2016

La Vie d’Adèle , Nymphomaniac et Love ont été interdits aux mineurs à la suite d’une action en justice menée par l’association Promouvoir. Ces cas de censure a posteriori menacent la liberté artistique du cinéma.
L’évidence du cauchemar
Authors: Cohn Danièle
Published: June 2016

Les images de violence extrême diffusées par les organisations terroristes ne sont pas des documents. Elles imposent un rapport inédit au vrai, qui exacerbe la peur et inhibe la pitié, à rebours de notre tradition iconographique.
Praxis de l’intersectionnalité : répertoires des pratiques féministes en France et au Canada
Authors: Lépinard Éléonore
Published: June 2016

Les théories féministes ont désormais largement adopté le concept d’intersectionnalité pour décrire et analyser les axes multiples d’oppression et leurs imbrications. Cependant, encore relativement peu de recherches explorent la question de savoir si les organisations de femmes dans différents contextes ont elles aussi adopté ce terme et l’analyse politique qu’il implique. À partir de données qualitatives recueillies auprès de militantes des droits des femmes en France et au Canada, cet article montre que l’intersectionnalité est un des répertoires discursifs possible — mais pas le seul — que les organisations de femmes peuvent utiliser pour analyser l’expérience sociale et les intérêts politiques des femmes situées à l’intersection de plusieurs rapports d’oppression. À partir des données qualitatives, l’article propose une typologie de quatre répertoires types que les militantes utilisent pour penser l’intersectionnalité et l’inclusion au sein de leurs organisations.
Enjeux et défis d’une politique féministe intersectionnelle - L’expérience d’Action des femmes handicapées (Montréal)
Authors: Masson Dominique
Published: June 2016

Le développement d’une perspective féministe intersectionnelle constitue la dernière réponse en date aux enjeux théoriques et politiques posés par l’existence des différences entre les femmes. Cet article s’interroge sur la façon dont les organisations féministes « font l’intersectionnalité », c’est-à-dire traduisent cette perspective théorique dans leur pratique politique. À partir de l’étude de l’association Action des femmes handicapées (Montréal), il vient documenter des usages politiques de l’intersectionnalité qui font appel à l’articulation du genre avec un axe de la domination qui demeure sous-représenté dans les études se réclamant des perspectives intersectionnelles : le capacitisme. L’article s’attache à cerner les éléments centraux de la politique féministe intersectionnelle déployée par cette association et de sa réception par les majoritaires « valides » du mouvement féministe québécois. Il soutient de plus que la pratique politique de l’intersectionnalité varie aujourd’hui selon que celle-ci est mise en œuvre par les « minoritaires » ou les « majoritaires » dans le mouvement féministe.
Cultures familiales et scolaires : réalités locales de familles défavorisées à Madagascar
Authors: Randriamasitiana Gil Dany
Published: June 2016

Cet article analyse les conditions d’apprentissages formels et informels des enfants de familles rurales malgaches de milieux défavorisés résidant dans les hautes terres centrales. Il met l’accent sur la socialisation scolaire des enfants et sur le mode de transmission des valeurs ancestrales. Les résultats qualitatifs et quantitatifs obtenus par des enquêtes auprès des parents et des entretiens auprès des enseignants montrent que la pauvreté ambiante, la disqualification sociale, les fluctuations des politiques de l’éducation constituent des facteurs qui peuvent perturber les processus de socialisation, de transmission des valeurs ancestrales et d’acquisition des connaissances à l’école primaire. D’importantes mesures mobilisant tous les acteurs de l’éducation s’imposent si l’on veut instaurer un système d’éducation inclusif, équitable et bénéfique aux enfants d’origine rurale de milieux défavorisés à Madagascar.
Environnement de travail, symptômes dépressifs et sentiment de désespoir : étude auprès de salariés
Authors: Nicolas Caroline , Desrumaux Pascale , Séguin Monique , Beauchamp Guy
Published: June 2016

En France, le suicide est considéré comme un problème de santé publique majeur depuis les années 1990. Au même moment, plusieurs auteurs ont commencé à souligner un accroissement de suicides dont la cause serait majoritairement liée au travail. Cependant, peu d’études empiriques ont été déployées. Cette étude analyse les liens éventuels entre des facteurs cliniques (symptômes dépressifs, sentiment de désespoir) et des éléments de l’environnement de travail, aux niveaux des caractéristiques du travail (i.e., latitude décisionnelle, soutien social au travail, efforts, récompenses), des relations (harcèlement moral au travail) et des facteurs psychologiques reliés au travail (satisfaction des besoins fondamentaux au travail, épuisement professionnel). Les données, récoltées au moyen d’un questionnaire auto-administré auprès de salariés de différents secteurs d’activité, ont mis en évidence des liens entre d’une part, des symptômes dépressifs et d’autre part, de faibles récompenses extrinsèques, un surinvestissement, des actes pouvant relever d’un harcèlement moral au travail et un épuisement émotionnel. De plus, des liens ont été relevés entre d’une part, un sentiment de désespoir et d’autre part, des efforts élevés, de faibles récompenses intrinsèques, une faible satisfaction du besoin de compétences au travail et un faible sentiment d’accomplissement personnel au travail. Les résultats invitent à considérer ces facteurs comme des pistes à privilégier dans un environnement de travail pour prévenir la santé mentale et le suicide.
Advances in Biometrics for Secure Human Authentication System
Authors: Mohan Jagannath , Kanagasabai Adalarasu , Pandu Vetrivelan
Published: June 2016

In the recent decade, one of our major concerns in the global technological society of information security is confirmation that a person accessing confidential information is authorized to perform so. Such mode of access is generally accomplished by a person's confirming their identity by the use of some method of authentication system. In present days, the requirement for safe security in storing individual information has been developing rapidly and among the potential alternative is implementing innovative biometric identification techniques. This chapter discusses how the advent of the 20th century has brought forth the security principles of identification and authentication in the field of biometric analysis. The chapter reviews vulnerabilities in biometric authentication and issues in system implementation. The chapter also proposes the multifactor authentication and the use of multimodal biometrics, i.e., the combination of Electrocardiogram (ECG) and Phonocardiogram (PCG) signals to enhance reliability in the authentication process.