bluuebunny/crossref_metadata_2025 huggingface dataset:
Na fronteira: mobilidades xamânicas entre Brasil e Guiana Francesa
Authors: Andrade Ugo Maia
Published: October 2018

Resumo Um complexo cenário de relações caracteriza a fronteira entre o Brasil e a Guiana Francesa, guardada pelo rio Oiapoque e habitada por 7000 índios. Habituados a deslocamentos contínuos para os principais centros urbanos regionais, os povos indígenas do Oiapoque têm uma longa história de interação com aglomerados populacionais de brasileiros, créoles e Saramaká. Por conta disso, famílias karipuna, galibi-kali’na, galibi-marworno e palikur habitam a aldeia e a cidade, transitando regularmente entre ambas e proporcionando novos aportes de conhecimentos ao xamanismo regional que dinamizam, revitalizam e transformam práticas e ideologias xamânicas em diálogo com formas congêneres situadas do outro lado das fronteiras territoriais e/ou simbólicas. Este artigo busca explicitar etnograficamente esse campo de relações e discutir a presença das formas de mediação que emergem nas fronteiras (entre sujeitos, práticas rituais, territórios, etc.), propondo refletir acerca das transformações do xamanismo regional e das novas modalidades que ele vem assumindo.
Gas production and in vitro degradability of sheep diets containing propolis ethanolic extract
Authors: Araujo Cintia Mirely de , Silva Fernanda Gomes Bezerra da , Castro Daniela Pionório Vilaronga , Menezes Daniel Ribeiro , Queiroz Mário Adriano Ávila , Yamamoto Sandra Mari
Published: October 2018

SUMMARY This study evaluated the influence of the propolis ethanolic extract (PEE) on gas production and in vitro degradability of sheep diets. Five experimental diets (treatments) were evaluated: without addition of PEE; 6 mL PEE; 12 mL PEE; 24 mL PEE and 36 mL PEE/kg concentrate. The experimental diet consisted of 50% elephant grass (Pennisetum purpureum) and 50% concentrate. There was a quadratic effect (P <0.05) for the volumes of total gas production (Vt), gases produced by the rapid degradation fractions (Vf1), and for in vitro degradability at 120 hours (Deg120), where the lowest values of Vt, Vf1 and Deg120, were found for the inclusion of 9.4 mL PEE/kg concentrate. Gas production by fermentation of the slow degradation fraction (Vf2) presented a mean of 25 mL/g DM (P <0.05). The colonization time of food particles (λ) significantly reduced (P<0.05) with increasing inclusion of PEE. Thus, it can be concluded that the PEE up to the inclusion of 9.4 mL/kg concentrate was efficient in inhibiting in vitro total gas production and from the fractions of rapid degradation by 9.9 and 15.3%, respectively, in addition to promoting a reduction of 5.3% in degradability after 120 h incubation in diets with a concentrate: forage ratio of 50:50. Thus, the inhibition in gas production was proportionally greater than the reduction of degradability.
Effect of roof painting of aviaries on thermal comfort, productive performance and physiological variables of broilers chickens
Authors: Valadares Leonora Ribeiro , Moreira Joerley , Dalólio Felipe Santos , Guimarães Maria Clara de Carvalho , Tinôco Ilda de Fátima Ferreira , Vaz Diego Pereira , Lima Héder José D’Avilla , Albino Luiz Fernando Teixeira
Published: October 2018

SUMMARY The objective this study was to evaluate the thermal comfort, performance and the physiological variables of 21-42 day of age broiler chickens housed in aviaries with painted and not painted fiber cement roof. A completely randomized design was used in a split-plot design where the plots were composed of the sheds (painted and not painted roof) and the subplots were the evaluation hours (6h00, 9h00, 12h00, 15h00 and 18h00) for a 22-day data collection, considered as the replicates. It was observed that the external painting in white of the roof provided improvements inside the shed for airtemperature (Ta), roof temperature (Tr) and the thermal load of radiation (TLR). The relative humidity (RH) and the Globe-Temperature-Humidity-Index (GTHI) varied only according to the collection times. The exterior painting of the roof had no effect on the physiological variables of the broilers. Productivity performance indexes and financial compensation per lot were better for the roof painted shed. As a result, fiber cement roof painted in white is recommended in aviaries located in hot climates, such as the region in this study.
Os comunistas e as práticas de educação física dos jovens na década de 1930 no Rio de Janeiro
Authors: Góis Junior Edivaldo , Soares Carmen Lucia
Published: October 2018

Resumo Este estudo buscou compreender como eram construídas as representações dos comunistas sobre a educação física dos jovens, em contraposição com outras vertentes políticas na década de 1930, principalmente no Rio de Janeiro. Embora as juventudes e seus agrupamentos tivessem diferentes objetivos e origens, nossa pesquisa pretendeu demonstrar que os grupos tutelados por movimentos políticos, como a juventude comunista, buscavam nas práticas de educação física, que comungavam e atraíam os interesses dessa população, legitimar seus objetivos através de sua crescente atuação em grupos de jovens atletas. Em termos metodológicos, realizamos uma pesquisa documental que teve como fontes principais jornais influenciados pelo movimento comunista e, em segundo plano, aqueles produzidos pelo movimento integralista. Utilizamos, ainda, reportagens da grande imprensa. Esse conjunto de fontes foi publicado, principalmente, no Rio de Janeiro, em cujos arquivos foram encontrados 36 documentos produzidos entre 1930 e 1937, os quais foram analisados a partir das categorias juventude e educação física. O estudo concluiu que, para os comunistas, as associações juvenis populares, promovidas pela prática de esportes amadores, seriam espaços propícios para o estabelecimento de vínculos entre a juventude comunista e os jovens atletas. Os comunistas perceberam as associações esportivas constituídas por grupos de jovens como espaços de disputa com os integralistas, uma vez que a luta ocorria também no campo cultural e não somente no político. Fomentar uma frente ampla, impactar a cultura juvenil, aproximar-se de outras experiências de juventude, como os grupos esportivos, era preparar a revolução tanto no aspecto cultural, como no político.
Large-diameter piles in chalk – part 2, design and construction
Authors: Ganesharatnam Lohini , O'Leary Frank , Morrison Paul , Kwan Vivien , Thorp Aidan
Published: October 2018

The design of a 60-storey tall residential tower with a two-level basement in east London has had to take account of two London Underground tunnels which pass beneath the centre of the site, resulting in ‘working’ pile loads of up to 45 MN. The foundation solution comprised a stiff raft with cast in situ bearing piles up to 2·4 m dia. and 61 m long founding in the grade A/B chalk stratum. Some piles, using bentonite support fluid, needed to be constructed within the tunnel exclusion zones, which required a concession from London Underground. This paper presents the Osterberg-cell preliminary pile load test and results, foundation design, working pile construction and limitations on piles constructed in the London Underground exclusion zones. The paper also discusses the control on the bentonite support fluid properties and monitoring of its properties during pile construction.
In situ tests for settlement design of compacted sand
Authors: Massarsch Karl Rainer , Fellenius Bengt H.
Published: October 2018

The reliability of settlement analyses depends on the selection of realistic input parameters. The tangent modulus method is proposed for the settlement analysis of uncompacted and compacted sand. The tangent modulus can be estimated based on the appropriate modulus number and corresponding stress exponents. Four concepts are presented, based on whether the modulus number is estimated from laboratory tests, empirical values or in situ tests (cone penetration tests and flat dilatometer tests). From the increase in horizontal stress following compaction, it is possible to estimate the overconsolidation ratio. A case history is presented to illustrate application of the proposed concepts.
Developing alternative business models for smart infrastructure: a UK case study
Authors: Bouch Chris J , Rogers Chris D F , Powell Mark J , Horsfall David A C
Published: October 2018

There is a need to identify as wide a range as possible of sources of value arising from a given infrastructure development when creating infrastructure business models. The need for novel, more effective business models is being driven by the UK government’s very considerable programme of infrastructure investment, coupled with a reduction in the supply of public capital over recent years and a corresponding increase in the demand for private project finance. To support both public and private infrastructure investment, new business models are required that can internalise the positive externalities associated with public goods. Based on an exploration of the application of soft systems methodology to business model creation, this paper proposes a generic six-step methodology for identifying a wide range of potentially value-generating opportunities and proves its efficacy by applying it to a case study of Tyseley Energy Park in Birmingham, UK. The findings from the methodology, which treats a newly constructed, refurbished or upgraded infrastructure system as a ‘business’, can then be used to broker the necessary collaboration with all relevant stakeholders – those who have a stake in the business – to refine the business models and ensure that they are resilient in the face of contextual change.
Dickkopf-3 (DKK3) in Urine Identifies Patients with Short-Term Risk of eGFR Loss
Authors: Zewinger Stephen , Rauen Thomas , Rudnicki Michael , Federico Giuseppina , Wagner Martina , Triem Sarah , Schunk Stefan J. , Petrakis Ioannis , Schmit David , Wagenpfeil Stefan , Heine Gunnar H. , Mayer Gert , Floege Jürgen , Fliser Danilo , Gröne Hermann-Josef , Speer Thimoteus
Published: October 2018

Background

The individual course of CKD may vary, and improved methods for identifying which patients will experience short-term eGFR loss are needed. Assessing urinary Dickkopf-3 (DKK3), a stress-induced tubular epithelia–derived profibrotic glycoprotein, may provide information about ongoing tubulointerstitial fibrosis and short-term eGFR loss.

Methods

To investigate urinary DKK3’s potential as a biomarker of short-term eGFR loss (over 12 months), we prospectively assessed eGFR and urinary DKK3 levels in patients with CKD of various etiologies at baseline and annual follow-ups. We also measured urinary DKK3 in a general population sample and patients with diagnostic kidney biopsies or IgA nephropathy under treatment.

Results

Median urinary DKK3-to-creatinine concentration at baseline was significantly higher in patients with CKD than the general population sample (431 versus 33 pg/mg). In the CKD cohort, having a urinary DKK3-to-creatinine level >4000 pg/mg was independently and significantly associated after multiple adjustments with mean annual decline in eGFR of 7.6% over 12 months. Urinary DKK3 significantly improved prediction of kidney function decline compared with eGFR or albuminuria alone. Urinary DKK3-to-creatinine levels were related to the extent of tubulointerstitial fibrosis in kidney biopsies. In patients with IgA nephropathy, a rise in urinary DKK3 was associated with significant eGFR decline within 6 months, whereas stable or decreasing urinary DKK3 indicated a more favorable course.

Conclusions

Urinary DKK3 levels identify patients at high risk for eGFR decline over the next 12 months regardless of the cause of kidney injury and beyond established biomarkers, potentially providing a tool to monitor CKD progression and assess effects of interventions.
METHEYLENE BLUE ADSORPTION AND PREPARATION SILVER BOUND TO ACTİVATED CARBON WITH SOL-GEL METHOD
Authors: Altıntığ Esra , Soydan Ömer Faruk
Published: October 2018

This
study examines the characterization and adsorption features of silver that was
added to oxygen containing activated carbons using the sol-gel method. The
surface area of the silver coated activated carbon (AC/Ag) Nano-composites,
which were prepared using the sol-gel method, was measured with the
Braunauer-Emmett-Teller surface area calculation method according to N2
adsorption at 77 K. The microstructure and surface morphologies of the AC/Ag
Nano-composite samples were examined with the use of Scanning Electron
Microscope. Methylene Blue removal was performed with AC/Ag-1 with 658.488 m2/g,
which had the highest surface area, and the Qmax value was calculated as 416.
66 mg/g.
A Sequence Bounded Above by the Lucas Numbers
Authors: Aydoğdu Ali , Özkan Engin , Göçer Aykut
Published: October 2018

In this work, we consider the sequence whose nth term is
the number of h-vectors of length n. The set of integer vectors E(n) is
introduced. For, n >=2, the cardinality of E(n) is the nth Lucas
number Ln is
showed. The relation between the set of h-vectors L(n) and the
set of integer vectors E(n) is given.
Asymptotically Lacunary I-Invariant Statistical Equivalence of Sequences of Sets Defined By A Modulus Function
Authors: Dundar Erdinç , P. Akın Nimet , Ulusu Uğur
Published: October 2018

In
this paper, we introduce the concepts of strongly asymptotically lacunary  I-invariant equivalence, f-asymptotically
lacunary I-invariant equivalence, strongly  f-asymptotically lacunary I-invariant equivalence and asymptotically lacunary I-invariant statistical equivalence for sequences of
sets. Also, we investigate some relationships among these concepts.
NİF OLYMPOS DAĞI ANTİK DÖNEM İNSANLARININ SAĞLIK SORUNLARI
Authors: YAVUZ Alper Yener , SEVİM EROL Ayla , ONUR İbrahim Semih
Published: October 2018

Nif Olympos Dağı Kazı ve Araştırma
projesi, konum olarak İzmir ili, Kemalpaşa, Torbalı, Buca ilçelerinin ortak
sınırlarındadır. İzmir (Smyrna) Körfezi’nin doğusunda yer alır. Kuzeyinde
Kemalpaşa (Nif / Kryos Çayı) Ovası ve Manisa (Sipylos) Dağı; doğusunda Smyrna-
Sardeis yolunu Küçük Menderes (Kaystros) Vadisi’ne bağlayan Karabel Geçidi;
güneyinde Torbalı Ovası yer alır (Tulunay 2006).

Proje kapsamında 4 farklı alanda kazı
çalışmaları yapılmaktadır. Bu 4 farklı kazı alanının dönemleri de birbirinden
farklıdır. Dönem gözetmeksizin yapılan kazı çalışmalarından ele geçen
iskeletler değerlendirildiğinde toplamda 97 birey tespit edilmiştir.  Ayrıca her bir alanda kendi içerisinde de demografi
çalışması yapılmıştır. Tespit edilen bireylerin 50’si erkek, 17 tanesi kadın,
10 tanesi çocuk, 4 tanesi bebektir. 16 bireyin ise cinsiyeti belirlenememiştir.
Nif Olympos Dağı Kazı ve Araştırma Projesi iskeletlerinde patolojik olarak da
birçok bulguya rastlanılmıştır. Özellikle bu bulgular içinde trepanasyonun
olması oldukça önemlidir. Nif Olympos Dağı Kazı ve Araştırma Projesi’nde ele
geçen trepanasyon örneği hem teknik olarak hem de uygulama bölgesi olarak
Anadolu örneklerinden oldukça farklıdır.
Mandibular asymmetry in Angle malocclusion samples
Authors: TERCANLI ALKIŞ Hümeyra , BİLGE Osman Murat
Published: October 2018

Purpose:
The purpose of this study was to investigate the effect of different types of
occlusion on mandibular asymmetry by using panoramic radiography in various
anatomical points.Materials and Methods:
This retrospective study included 100 patients whose panoramic images and
malocclusions were registered in a patient database. Asymmetry indices were
evaluated according to the Habets asymmetry index formula using linear and
angular measurements of images. The effects of malocclusions, age and gender on
the asymmetry indices were investigated and ˂0.05 p value was considered
significant Results:
Of the total 100 patients 51 (51%) were female and 49 (49%) were male. Associations
were found between gender and the right corpus length, right and left gonial
angle values, and between malocclusion and the right condylar height and right
and left corpus length.

 Conclusion:
Although values of some parameters varied with gender and malocclusion, there
was no statistically significant relationship found between age, gender and
malocclusion and asymmetry index values for any parameter.
PCR Cloning with Blue/White Selection and Easy Insert Excision v2
Authors: not provided Promega , Wagner Trevor
Published: October 2018

Protocol for PCR Cloning with Blue/White Selection and Easy Insert Excision using pGEM®-T Easy Vector Systems. (For use with A3600, A3610, A1360, or A1380.)
On-line microscopy and histology resources v1
Authors: Mikulski Zbigniew
Published: October 2018

There is a weath of microscopy-related information online. This document lists the one we know and like.
Nucleic Acid Purification: Bead Clean v1
Authors: Y Mayday Madeline , M Khan Lillian , D. Chow Eric , S. Zinter Matt , L. DeRisi Joseph
Published: October 2018

Preparation of high-quality sequencing libraries is a costly and time-consuming component of metagenomic next generation sequencing (mNGS). While the overall cost of sequencing has dropped significantly over recent years, the reagents needed to prepare sequencing samples are likely to become the dominant expense in the process. Furthermore, libraries prepared by hand are subject to human variability and needless waste due to limitations of manual pipetting volumes. Reduction of reaction volumes, combined with sub-microliter automated dispensing of reagents without consumable pipette tips, has the potential to provide significant advantages. Here, we describe the integration of several instruments, including the Labcyte Echo 525 acoustic liquid handler and the iSeq and NovaSeq Illumina sequencing platforms, to miniaturize and automate mNGS library preparation, significantly reducing the cost and the time required to prepare samples. Through the use of External RNA Controls Consortium (ERCC) spike-in RNAs, we demonstrated the fidelity of the miniaturized preparation to be equivalent to full volume reactions. Furthermore, detection of viral and microbial species from cell culture and patient samples was also maintained in the miniaturized libraries. For 384-well mNGS library preparations, we achieved a savings of over 80% in materials and reagents alone, and reduced preparation time by 90% compared to manual approaches, without compromising quality or representation within the library. This automated, miniaturized protocol for bead cleaning can be used with theHigh-Throughput Echo Library Prep Protocol for processing up to 384 samples simultaneously. To facilitate the miniaturized columes required by this protocol, we have included the .STL file for our 3D-printed adaptor, which, when placed on the magnet, raises the height of the PCR plate, thereby lowering the beads inside of the well and allowing for elutions in as low as 6uL.
High-Throughput Library Pooling for NGS v1
Authors: Y Mayday Madeline , M Khan Lillian , D. Chow Eric , S. Zinter Matt , L. DeRisi Joseph
Published: October 2018

Preparation of high-quality sequencing libraries is a costly and time-consuming component of metagenomic next generation sequencing (mNGS). While the overall cost of sequencing has dropped significantly over recent years, the reagents needed to prepare sequencing samples are likely to become the dominant expense in the process. Furthermore, libraries prepared by hand are subject to human variability and needless waste due to limitations of manual pipetting volumes. Reduction of reaction volumes, combined with sub-microliter automated dispensing of reagents without consumable pipette tips, has the potential to provide significant advantages. Here, we describe the integration of several instruments, including the Labcyte Echo 525 acoustic liquid handler and the iSeq and NovaSeq Illumina sequencing platforms, to miniaturize and automate mNGS library preparation, significantly reducing the cost and the time required to prepare samples. Through the use of External RNA Controls Consortium (ERCC) spike-in RNAs, we demonstrated the fidelity of the miniaturized preparation to be equivalent to full volume reactions. Furthermore, detection of viral and microbial species from cell culture and patient samples was also maintained in the miniaturized libraries. For 384-well mNGS library preparations, we achieved a savings of over 80% in materials and reagents alone, and reduced preparation time by 90% compared to manual approaches, without compromising quality or representation within the library. After library preparation, the next step before putting samples on the sequencer is to pool samples to be able to multiplex sequencing. Final concentrations of each sample will vary from sample to sample depending on various things like RNA input, library prep, and PCR cycles among other factors. It is difficult tomanually quantify and pool uniformly 384 samples, so that is why we employ robots. To quickly and accurately pool hundreds of samples at a time, we employed a two-step method. Using the Labcyte Echo, equal volumes of each library are pooled together and sequenced on the Illumina iSeq or MiSeq sequencing platforms to determine the representation of each library in the total pool.Using this information, libraries were pooled using the Echo into a normalized pool for downstream sequencing on the Illumina NovaSeq.
Estimating the juvenile survival rate of male Northern Fur (Сallorhinus ursinus): mathematical modelling and data analysis
Authors: Zhdanova O.L. , Kuzin A.E. , Frisman E.Ya.
Published: October 2018

For the sustainable use of the northern fur seal stocks, estimation and prediction of the number of the main age groups of males is very important. The data of direct observations make it possible to estimate only the size of the offspring (the number of pups) and the total number of bulls; and the age composition of the animals killed by the harvest is also known. It is necessary to be able to calculate the survival rates of individual age groups of fur seals to predict population dynamics using these data. This paper discusses and modernizes the previously proposed methods for estimating the survival rates of males. To narrow the calculated intervals of juvenile survival we use additional information (in particular, the estimated survival of males at subsequent stages of the life cycle), as well as adjust the evaluation procedure. Two methods for calculating the survival rates of males at different stages of the life cycle are proposed: the iteration method and the method of determining the survival limits of all age groups from the dynamic equations. Both methods are based on available observational data and features of the life cycle of the species in question, they do not require fulfillment of any assumptions about the nature of the harvest strategy. We obtain, as a result, satisfactory estimates of the coefficients characterizing the main stages of the life cycle of fur seal males. Moreover, both methods give very similar regression estimates of the average bulls’ survival: they hardly differ in size and have similar statistical characteristics. Thus, the first method gives higher juvenile survival and low survival of bachelors; and the second method, on the contrary, overestimates the survival of bachelors and underestimates the juvenile survival rate. However, as the regression analysis showed, both sets of estimates are well compatible with observational data.
Água tratada magneticamente para irrigação: efeitos na produção e eficiência do uso da água na cultura da cenoura (Daucus carota L.)
Authors: Putti Fernando Ferrari , Gabriel Filho Luís Roberto Almeida , Cremasco Camila Pires , Silva Junior Josué Ferreira
Published: October 2018

A cultura da cenoura vem aumentando sua representatividade na produção de hortaliças devido a seus benefícios para a saúde humana. Objetivou-se neste trabalho analisar a consequência de diferentes lâminas de irrigação utilizando água tratada magneticamente e potável para a cultura da cenoura. O experimento foi conduzido na Faculdade de Ciências Agronômicas (FCA-UNESP), Campus de Botucatu-SP (Brasil), entre os meses de setembro a dezembro de 2015. Adotou-se o delineamento experimental em blocos casualizados, em esquema fatorial de 2×5 com 10 repetições. Assim, os tratamentos foram 2 tipos de água (água tratada magneticamente e potável), e 5 lâminas de reposição que corresponderam aos percentuais da evapotranspiração (25, 50, 75, 100 e 125% da Etc), utilizando a irrigação por gotejamento. Constatou-se que a irrigação com água tratada magneticamente proporcionou um incremento na massa de matéria fresca, sendo que a lâmina que obteve a maior produção foi a de 100 e 125% da Etc, assim verificando a possibilidade do aumento da produtividade da cenoura. Se constatou aumento significativo para a o número de folhas, comprimento de bulbo e diâmetro para a cultura da cenoura quando irrigada com água tratada magneticamente.
Acumulación de biomasa en yuca (Manihot esculenta C.) ante la respuesta a la aplicación de fertilizantes NPK y biofertilizantes en condiciones de invernadero en dos tipos de suelo
Authors: Pérez-Pazos Jazmín Vanessa , Luna-Castellanos Lily Lorena , Burbano-Figueroa Oscar
Published: October 2018

El cultivo de la yuca en el Caribe colombiano es un sistema productivo con un bajo nivel de integración de tecnologías modernas sustentables que permitan incrementar la rentabilidad del cultivo. La validación de prácticas asociadas a la fertilización conforma una de las alternativas para incluir en las estrategias de manejo integrado del cultivo. El objetivo de este estudio fue evaluar a nivel de casa malla, la respuesta de acumulación de biomasa en plantas de yuca a la fertilización NPK en dos tipos de suelos (arenoso y franco-arcilloso) y en presencia de tres biofertilizantes. El efecto de diferentes inoculantes microbianos comercialmente disponibles, Azobac® (Azotobacter chrococcum), Fosforiz® (Pseudomonas fluorescens) y micorrizas arbusculares (Safer Micorrizas ®), fue evaluado en mezcla con diferentes niveles de fertilización inorgánica (100, 75, 50, 25 y 0%), más los testigos sin inoculación en un arreglo factorial 2×3×5. Los resultados obtenidos indican que el nivel de fertilización NPK en el que se alcanza la mayor acumulación relativa de biomasa ocurre al 25% de la mezcla. Los mayores valores de acumulación de biomasa se alcanzan con la presencia de micorrizas. Azobac® y Fosforiz ® no exhibieron ningún efecto sobre la acumulación de biomasa. Los resultados obtenidos sugieren que los biofertilizantes comerciales basados en micorrizas pueden ser usados para maximizar la respuesta a la fertilización con NPK.
ÍNDICES DE DESENVOLVIMENTO RURAL: COMPARAÇÃO ENTRE OS MUNICÍPIOS DO VALE DO RIO CUIABÁ E OS DEMAIS MUNICÍPIOS DE MATO GROSSO: 2000 E 2008
Authors: Muniz Meiresângela Miranda , Pereira Benedito Dias
Published: October 2018

A partir dos anos mais recentes, a base econômica dos municípios do Vale do Rio Cuiabá e dos outros municípios do Estado de Mato Grosso se movimentam em trilhas convergentes, produzindo os bens que mais se destacam na agropecuária do Estado: a soja, o algodão, o milho e os bovinos. Embora haja essa confluência, as economias dos municípios que compõem o Vale do Rio Cuiabá ainda exibem diferenças em relação às economias dos demais municípios mato-grossenses. Nesse contexto, com adoção do método de análise multivariada, pesquisa-se sobre os contrastes do desenvolvimento rural entre esses dois conjuntos de municípios. Os principais resultados revelam que as economias dos municípios que fazem parte do Vale, de modo geral, em comparação com grande parte dos outros municípios mato-grossenses, vêm apresentado índices mais reduzidos de desenvolvimento rural.
VALORAÇÃO AMBIENTAL DO PARQUE MUNICIPAL LAGOA ENCANTADA, CUIABÁ (MT)
Authors: Leão Suelen da Veiga Borges , Sousa Roberto Antonio Ticle de , Pasa Maria Corette
Published: October 2018

Este trabalho tem como objetivo expressar o valor de uso recreacional do Parque Municipal Lagoa Encantada (PMLE), utilizando-se os métodos de Valoração Contingente e o método do Custo de Viagem. O estudo foi desenvolvido no perímetro urbano de Cuiabá, com os dados coletados através de questionários em entrevistas feitas aleatoriamente junto aos usuários do Parque. Aplicou-se 110 questionários. Os valores obtidos pelo Método Custo de Viagem mostram que os frequentadores entrevistados no parque têm uma disposição para desembolsar o equivalente a R$ 1,03/pessoa/visita ao parque. A disposição média a pagar encontrada para o público entrevistado pelo Método de Valoração Contingente foi de um valor que se situa entre R$ 0,50 e R$ 1,00 por pessoa/visita ao parque. O parque atende todas as faixas etárias, característica que demonstra acerto na estrutura e funcionamento no atendimento ao público de ambos os sexos. A maioria dos usuários (80,9%) reside nas imediações do parque, demonstrando que a proximidade do parque é forte atrativo para visitação principalmente para atividades físicas como a caminhada. Entre os 110 entrevistados, existe uma maior proporção de visitantes do sexo feminino, 61,8%, e 38,2% dos frequentadores do sexo masculino. Pelo Método de Custo de Viagem o valor do parque foi de um total estimado de R$ 589.489,60. Pelo Método Contingente a disposição média a pagar foi de R$ 1,00 um total estimado de R$ 572.320,00 como o valor do parque pelo Método de Valoração Contingente na melhor das hipóteses.
PESO-COMPRIMENTO E FATOR DE CONDIÇÃO RELATIVO DE Bryconamericus iheringii EM RIACHOS DO PARANAPANEMA
Authors: Caetano Dyego Leonardo Ferraz , Jané Daniela Ribas
Published: October 2018

Foram analisados a relação peso-comprimento e o Fator de Condição Relativo (Kn) de peixes da espécie Bryconamericus iheringii capturados em três riachos da bacia do rio das Cinzas, Alto rio Paraná, para estimar, respectivamente, o tipo de crescimento e o bem-estar das populações. Análises de Variância (ANOVA Unifatorial) foram utilizadas para verificar diferenças significativas nos valores de peso, comprimento e Kn entre os riachos, e análises de correlação (Spearman) indicaram a relação entre esses parâmetros supracitados e os fatores físicos e químicos e densidade populacional nos riachos. Os indivíduos do riacho Ubá, considerado o mais preservado com relação à vegetação ripária entre os três estudados, apresentaram maiores valores de peso, comprimento e Kn. Os indivíduos dos riachos Água dos Anjos e Monjolinho exibiram crescimento alométrico negativo, com maior acréscimo em comprimento (mm), e os do riacho Ubá, alométrico positivo, com ganho maior em peso (g). O Kn se correlacionou (p < 0,05) negativamente com a densidade e a condutividade, e a condutividade baixa, por consequência, teve correlação com a alta extensão da mata ripária. Portanto, o presente trabalho mostra indícios de que os parâmetros de relação peso-comprimento e de Kn de peixes de riacho podem ser influenciados significativamente pelas características ambientais relacionadas principalmente à vegetação marginal, podendo ser boas métricas complementares para entender a resposta desses organismos às alterações antrópicas.
ANÁLISE DA INFLUÊNCIA DO PRÉ-TRATAMENTO QUÍMICO E FÍSICO SOB A CARACTERIZAÇÃO DAS FRAÇÕES CELULOSE E LIGNINA DE DIFERENTES BIOMASSAS E SEU POTENCIAL PARA PRODUÇÃO DE ETANOL DE SEGUNDA GERAÇÃO
Authors: Coelho Andrade Thaysi Castro , Siqueira Lara Neira de , Souza Dener Alves de , Silva Fabricia Vieira , Guarda Patricia Martins , Guarda Emerson Adriano
Published: October 2018

O desenvolvimento do etanol lignocelulósico, obtido a partir de biomassas consideradas resíduos, tem ocupado posição de destaque junto às pesquisas realizadas sobre o tema energético. Neste trabalho utilizou-se as biomassas bagaço de cana-de-açúcar, capim elefante e serragem de madeira (Angelim vermelho) para a avaliação dos teores de celulose e lignina antes e depois de serem submetidas a uma combinação de pré-tratamentos que envolvem pré-tratamento físico e pré-tratamento químico (ácido e alcalino). Desta forma pôde-se avaliar se a aplicação desses pré-tratamentos é favorável para o processo de hidrólise enzimática para geração de açúcares fermentescíveis e posterior processo de fermentação microbiana para obtenção de etanol lignocelulósico. Os resultados nos permitiram concluir que a combinação de pré-tratamentos foi mais satisfatória para promover a deslignificação, que é uma das principais barreiras encontradas para a geração do etanol lignocelulósico sendo que o teor de lignina para a cana-de-açúcar obteve redução de 46,53% após submissão ao pré-tratamento, na serragem a redução foi de 28,45%, enquanto que o capim elefante obteve melhor resultado com 62,16% de redução. Quanto ao teor de celulose os resultados variaram em função das biomassas, para a cana-de-açúcar ocorreu uma maior disponibilidade da celulose com acréscimo de 12,21%, para as outras duas biomassas observou-se que o pré-tratamento provocou perda de celulose disponível, tendo em vista que ocorreu redução no teor de 8% para o capim elefante e de 18,62% para a serragem.
Позиции взаимодействия студентов в контексте проблем обеспечения психологической безопасности личности
Authors: Маралов Владимир Григорьевич , Фортунатов Артем Александрович , Шонин Максим Юрьевич
Published: October 2018

Актуальность проблемы обусловлена значимостью выявления факторов, обусловливающих принятие людьми позиций взаимодействия: принуждения, манипулирования, ненасилия и невмешательства, которые могут быть оценены с точки зрения безопасности. Цель исследования состояла в выявлении взаимосвязи позиций взаимодействия с потребностями в опасности и безопасности, мотивацией достижения успеха и избегания неудач, склонностью к риску, сензитивностью (чувствительностью) к угрозам и выбором адекватных или неадекватных способов реагирования в ситуациях опасности. Использовались авторские опросники на выявление позиций взаимодействия у студентов, потребностей в опасности и в безопасности, сензитивности к угрозам, выборов адекватных или неадекватных способов реагирования в ситуациях опасности, а также тесты Т. Элерса на выявление мотивации достижения успеха и избегания неудач, тест Г. Шуберта, диагностирующий готовность личности к риску. Всего в исследовании приняли участие 122 студента Московского гуманитарного университета и Череповецкого государственного университета в возрасте от 18 до 22 лет. Исследование проводилось в 2018 г.

В результате была выявлена положительная связь позиции принуждения с потребностью в переживании чувства опасности, стремлением к игнорированию угроз, мотивацией достижения. Позиция манипулирования обнаружила такие же связи, кроме того, выявлена связь с сензитивностью к угрозам. Позиция ненасилия положительно коррелирует с потребностью в обеспечении безопасности, стремлением к избеганию неудач, сензитивностью к угрозам и выбором адекватных способов реагирования. Позиция невмешательства положительно связана в первую очередь с потребностью в переживании чувства безопасности, а также с потребностью в обеспечении безопасности, выраженным стремлением к избеганию неудач, стремлением к преувеличению значения опасностей. Проведенное исследование со всей очевидностью показало, что в процессе формирования у студентов способности к ненасильственному взаимодействию необходимо обращать внимание не только на ценностную сторону ненасилия как оптимального способа взаимодействия людей друг с другом, но и на мотивационные факторы, в частности на формирование потребности в обеспечении безопасности. Полученные результаты могут быть использованы при разработке специальных программ и технологий формирования у студентов — будущих педагогов, психологов, социальных работников, дефектологов, врачей и т. п. способности к ненасильственному взаимодействию.
Стыд и моральная ответственность организованных коллективов
Authors: Прокофьев Андрей Вячеславович
Published: October 2018

Цель данной статьи — выявить место моральной эмоции стыда в механизмах моральной ответственности организованных коллективов (бизнес-корпораций, самоуправляющихся ассоциаций, государственных организаций). В своих ретроспективных проявлениях моральная ответственность тесно связана с осуждением нарушителя нравственной нормы. Нарушитель подлежит внешнему осуждению, но и от него самого также ожидается осуждение совершенного им поступка.  Признаком подлинности самоосуждения принято считать наличие негативных эмоций самооценки, таких как вина и стыд.

В рамках данного исследования используется такое понимание стыда, при котором он является негативной эмоцией, возникающей на фоне действительной или потенциальной осведомленности других людей о совершенном нарушении и сосредоточенной на проявившемся в поступке моральном качестве личности нарушителя. Вина, в свою очередь, не обусловлена внешними факторами и сосредоточена на моральном качестве самого действия и его последствий. Организованные коллективы можно рассматривать в качестве деятелей, способных нести моральную ответственность в силу наличия у них внутренних структур принятия решений (термин П. Френча). К примеру, решения бизнес-корпорации можно отграничить от решений ее менеджеров, не выражающих намерений организованного коллектива. Существенным затруднением для признания таких коллективов ответственными моральными деятелями является отсутствие у них аффективной составляющей поведения: тот, кто не способен осуждать себя в эмоциональных формах, не подлежит моральному осуждению. Однако более глубокий анализ свойств организованного коллектива позволяет утверждать, что он обладает функциональными аналогами или субститутами эмоций самооценки. При этом они гораздо больше похожи на индивидуальный стыд, чем на индивидуальную вину. Организованный коллектив способен как выражать стыд, так и опасаться стыда. Эта его особенность должна найти отражение в системе наказания бизнес-корпораций. В их отношении уместно использовать так называемые пристыжающие санкции, наносящие удар по корпоративной репутации.
Investigation of the Esterase Status as a Complex Biomarker of Exposure to Organophosphorus Compounds
Authors: Makhaeva G.F. , Rudakova E.V. , Richardson R.J.
Published: October 2018

Development of biomarkers of human exposures to organophosphorus compounds OPCs and their quantification is a vital component of a system of prediction and early diagnostics of OPC-induced diseases. Our study was focused on investigation of esterase status as a complex biomarker of exposure to OPCs and an aid in accurate diagnosis. We suggest that this complex biomarker should be more effective and informative than standard assays of plasma butyrylcholinesterase (BChE), erythrocyte acetylcholinesterase (RBC AChE), and lymphocyte neuropathy target esterase (NTE). It will help: 1) to assess an exposure as such and to confirm the nonexposure of individuals suspected to have been exposed; 2) to determine if the exposure was to agents expected to produce acute and/or delayed neurotoxicity; 3) to perform dosimetry of the exposure, which provides valuable information for medical treatment. To confirm this hypothesis, we have examined the changes in activity of blood AChE, NTE, BChE and carboxylesterase (CaE) 1 h after i.p. administration of increasing doses of three OPCs with different esterase profiles: the known neuropathic compound O,O-dipropyl-O-dichlorovinyl phosphate (C3H 7O)2P(O)OCH=CCl2 (diPr-DClVP) as the control compound and two model dialkylphosphates (C2H5O)2P(O)OCH(CF3)2 (diEt-PFP) and (C4H9O)2P(O)OCH(CF3)2 (diBu-PFP). The esterases assay was performed in hemolysed blood by spectrophotometric (AChE, BChE, CaE) and biosensor (NTE) methods. Analysis of the obtained dose-dependences for blood esterases inhibition showed that blood BChE and CaE were the most sensitive biomarkers, allowing detection of low doses. Inhibition of blood NTE and AChE can be used to assess the likelihood that an exposure to OPC would produce cholinergic and/or delayed neuropathic effects.
Properties of Calcium-Activated Chloride Currents in Rat Purkinje Cerebellum Neurons
Authors: Zamoyski V.L. , Bovina E.V. , Grigoriev V.V.
Published: October 2018

The presence of calcium-activated chloride current was shown using on freshly isolated rat Purkinje cerebellum neiurones and the pacth-clamp method in the whole-cell configuration. Chloride currents appeared in sodium-free external solution and reversibly disappeared in chloride-free or calcium-free external solution. Replacing of K+ ions (120 mM) to Cs+ ions in micropipette (120 mM) show the chloride currents even with 140 mM Na+ in external solution. This current was blocked to 80–100% by nifluminic acid (25–100 ΜM). It was found out that well known blockers of potassium channels tetraethylammonium (TEA) and 4-aminopyridine (4-AP) also effectively blocked chloride channels. The IC50 values for TEA and 4-AP were 130 ΜM, and 110 ΜM respectively. The action of TEA was reversible, while 4-AP at concentration 100 ΜM and above irreversibly blocked chloride channels.
Crown-Containing Phthalocyanines are Potential Sensibilizers for Photodynamic Therapy. Synthesis, Properties and Role of Non-Covalent Interactions
Authors: Baulin V.E. , Goldshleger N.F. , Baulin D.V. , Kalashnikova I.P.
Published: October 2018

Phthalocyanines (Pc) and their supramolecular aggregates are widely used in molecular electronics, chemical sensors, and catalysis, as well as in biology and medicine, including photodynamic therapy (PDT). One of the possibilities of preventing Pc aggregation in an aqueous medium is using surfactants: with their molecules are self-organized various supramolecular complexes. This results in formation of the required microheterogeneous Pc environment compatible with the biological medium. The monomolecular state of Pc in an aqueous medium is especially important for their use as sensitizers in fluorescence diagnostics and PDT. We have summarized here the results of investigations of distinctive features of the supramolecular aggregation of octa-[(4′-benzo-15-crown-5)oxy]phthalocyaninates (Mcr8Pc) and tetra-[(4′-benzo-15-crown-5)oxy]phthalocyaninates (Mcr4Pc) in electrolytic solutions and solutions of synthetic cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS), sodium dodecylbenzenesulfonate (SDBS). Biocompatible surfactants such as carboxymethylcellulose sodium salt (Na-CMC) and sodium deoxycholate (SDC) were also studied. Using the electron absorption spectra it has been shown that formation of Mсr8Pc monomers in micellar solutions of SDC is affected by both increased surfactant concentration and by changes in the ionic strength of solution after sodium chloride is added. The effect of the chemical structure of the biocompatible anionic surfactant on monomerization of crown_containing phthalocyanines has been identified; this fact opens new possibilities for using this family of compounds for fluorescent diagnosis and PDT.
1,5-bis[2-(dioxyphosphoryl)-4-ethylphenoxy]-3-oxapentane and its Analogs as Promising Organic Ligands for Copper(II) Binding s
Authors: Baulin V.E. , Tsebrikova G.S. , Baulin D.V. , Al Ansary Y.F.
Published: October 2018

The dissociation and complexation ability toward Cu(II) of acidic type phosphoryl-containing podands – tetrabasic 1,5-bis[2-(dioxyphosphoryl)-4-ethylphenoxy]-3-oxapentane (L1), dibasic – 1,5-bis[2-(ethoxyhydroxyphosphoryl)-4-ethylphenoxy]-pentane (L2) and also of their carboxylic analogue dibasic 1,5-bis[2-(oxycarbonylphenoxy)]-3-oxapentane (L3) were investigated by spectrophotometric, conductometric and potentiometric methods in water in the presence 5% of dimethyl formamide. Spectrophotometric and conductometric titration data provided evidence for formation of 1:1 (M:L) complexes. The dissociation constants were determined and species distribution diagrams for studied acids were obtained by potentiometric method. These data are of interest for the design of binary extragents and medicinal drugs based on the studied ligands. The stability constants of Cu(II) 1:1 (M:L) complexes were estimated. Analysis of the titration curves suggests that deprotonation forms of the studied ligands react with Cu2+. Substitution of carboxylic groups in acyclic polyesters by phosphonic results in increased stability of the copper(II) complexes
Protective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells
Authors: Dubrovskaya E.S. , Semakov A.V. , Afanasyeva S.V. , Neganova M.E. , Kozlovski V.I. , Klochkov S.G.
Published: October 2018

An the present study we evaluated the effect of natural sesquiterpene lactones of plants of the genus Inula on the cells of neuroblastoma SK-N-MC under conditions of toxic stress induced by H2O2 and glutamate. Lactones increased cell survival under these conditions and the leader compounds were identified in this series. A putative mechanism for the protective action of lactones on cells under condition toxic stress has been proposed.
Computational Evaluation of Selectivity of Inhibition of Muscarinic Receptors M1-M4
Authors: Mikurova A.V. , Skvortsov V.S. , Raevsky O.A.
Published: October 2018

A set of models for preliminary estimation of the inhibition constant values of potential ligands for the 4 acetylcholine muscarinic receptors M1-M4 was developed. The study uses an information about three-dimensional structure of human M1, M2 and M4 receptors, as well as the M3 receptor model, constructed by homology based on the structure of the rat M3 receptor. The Ki values for 42 compounds were obtained from the sources. Modeling of “protein-ligand” complexes was performed using molecular docking and molecular dynamics procedures. The component energy characteristics of the complexes were calculated from data obtained from simulation of molecular dynamics by the MM-PBSA/MM-GBSA methods. These characteristics were used as independent variables to construct the linear regression equations for pKi value predicting. The equations obtained for each receptors allow us to predict pKi with an average accuracy of 0.65 logarithmic units.
Laryngeal malignancy: epidemiology and staging at the time of presentation in a rural population
Authors: Shariff Mudassar A.
Published: October 2018

Background: Laryngeal cancer is one of the 10 leading causes of cancer in Indian men. Late presentation of the disease may worsen management outcomes. Consumption of tobacco and alcohol is associated with the development of laryngeal malignancy.

Methods: A cross-sectional study was conducted in the Department of ENT, at Chamarajanagar Institute of Medical Sciences and Hospital, Chamarajanagar, India, for a period of 2 years 6 months from October 2014 to March 2017. During the study period, all cases that were diagnosed as Laryngeal malignancy by histopathology were included in the study group. The aim of this study is to determine the epidemiology, anatomical location of the tumor at presentation, clinical presentation and the stage of the tumor at the time of presentation.  

Results: Majority of patients were elderly male from lower socio-economic strata. The most common clinical presentations were change in voice, pain in throat, difficulty in swallowing, lump in neck and difficulty in breathing. Supraglottis (82%) was the most common anatomic location of tumor. 60% of the patients presented in stage III of the disease. All the cases were squamous cell carcinoma.

Conclusions: Laryngeal malignancy is a relatively uncommon malignancy in general population but is more common in rural population especially in people belonging to lower socio-economic strata. Supraglottic malignancy is the most common anatomic location of laryngeal malignancy. Majority of the cases from rural population presented in an advanced stage of the disease.
 CATOLICISMO NEW AGE NUMA COMUNIDADE NEO-ESOTÉRICA: INSTITUCIONALIDADE “MONÁSTICA” E APARIÇÃO DE UMA VIRGEM CÓSMICA E ENERGÉTICA
Authors: Camurça Marcelo Ayres , Campanha Vitor De Lima
Published: October 2018

O presente artigo trata da suposta aparição de Maria em uma comunidade neo-esotérica situada no sul de Minas Gerais. Assentada no contexto da pós-modernidade religiosa com sua dinâmica de desinstitucionalização e trânsito religioso, a aparição e o grupo nela envolvido são permeados por crenças new age e práticas católicas mimetizadas, figurando como um exemplo da porosidade do Catolicismo às tendências do “espírito da época”.
The Cognitive Outcome of Posterior Reversible Encephalopathy Syndrome
Authors: Forteza FJ Ros
Published: October 2018

Letter to Editor