bluuebunny/crossref_metadata_2025 huggingface dataset:
Conspecific interactions predict social transmission of fear in female rats
Authors: Seese Sydney , Tinsley Carolyn E , Wulffraat Grace , Hixon J. Gregory , Monfils Marie H.
Published: May 2023

Social transmission of fear occurs in a subset of individuals, where an Observer displays a fear response to a previously neutral stimulus after witnessing or interacting with a conspecific Demonstrator during fear memory retrieval. The conditions under which fear can be acquired socially in rats have received attention in recent years, and suggest that social factors modulate social transmission of information. We previously found that one such factor, social rank, impacts fear conditioning by proxy in male rats. Here, we aimed to investigate whether social roles in females also have an influence on social transmission of fear. In-line with previous findings in males, we found that social interactions in the home cage can provide insight into the social relationship between female rats and that these relationships predict the degree of fear acquired by-proxy. These results suggest that play behavior may provide a valuable assessment of dominance hierarchy in female rats.
Probiotic Potential, Antibacterial and Antioxidant Capacity of Aspergillus luchuensis YZ-1 Isolated from Liubao Tea
Authors: Zhang Xiyan , Jiao Rui , Li Hui , Ou Dexin , Zhang Danfeng , Shen Yizhong , Ling Na , Ye Yingwang
Published: May 2023

Aspergillus fungi are widely used in the traditional fermentation of food products, so their safety risks and functions are worthy of investigation. In this study, one Aspergillus luchuensis YZ-1 isolated from Liubao tea was identified based on phylogenetic analyses of sequences of three genes coding for internal transcribed spacer 1 (ITS1), β-tubulin (benA) and calmodulin (CaM). The results of hemolytic activity, Dnase activity, cytotoxicity assay and antibiotic resistance assay indicated that the strain is potentially safe. The excellent gastrointestinal fluids tolerance, acid tolerance, bile tolerance, auto-aggregation, co-aggregation, cell surface hydrophobicity and adhesion to human colon adenocarcinoma (HT29) cell line were observed on analysis of the probiotic properties. Furthermore, the results of the antibacterial activity of A. luchuensis YZ-1 indicated that the strain had strong antagonistic effects against Gram-negative and Gram-positive bacteria as well as fungi. Simultaneously, the water extracts and 80% ethanolic extracts of A. luchuensis YZ-1 cells also showed strong ABTS, DPPH and OH− scavenging ability. Taken together, our results suggest that A. luchuensis YZ-1 has desirable functional probiotic properties and can be proposed as a biocontrol agent in the food industry.
Motion Events in English Language Teaching: An investigation of Manner in the context of Australia, Iran, and Turkey
Authors: Banaruee Hassan , Farsani Danyal , Khatin-Zadeh Omid , Eskandari Zahra , Askari Afsane
Published: May 2023

Motion events have been the target of many studies since their introduction by Talmy (1985). The overwhelming majority of investigations have compared languages cross-culturally with English and Spanish (see, Slobin, 1996, 2004, 2005). The literature is ultimately in need of the practice of this cognitive typology. Since motion events represent cognitive styles and conceptualizations, language teaching and learning is a controversial subject of investigation. To provide insights and contribute to the development of English Language Teaching (ELT) worldwide, we conducted this interdisciplinary study on the verge of cognitive linguistics and ELT. We compared EFL textbooks taught in Iran and Turkey, employing the context of Australia as the source of comparison as the target language. Data were collected from two corpora; one consisting of three English textbooks taught at high schools and one consisting of three novels in each language. Having analyzed the motion components in the corpora, we discovered the discrepancies and diversity of patterns in the languages and the corresponding English textbooks. A detailed comparison ofMannerin these languages revealed that Talmy's typology needs further investigations for a more robust classification of languages. The EFL textbooks in Iran and Turkey do not fully picture English cognitive structures.
Biomechanical testing, finite element analysis and prospective, randomized, clinical study of single screw chephalomedullary nailing vs integrated dual interlocking screw fixation for unstable (31A21-3) intertrochanteric fractures in patients > 70 years old.
Authors: Panagopoulos Andreas , Argyropoulou Evangelia , Kokkalis Zinon T , Parchas Nikolaos , Tserpes Konstantinos
Published: May 2023

Background: Hip fractures are an increasingly common consequence of falls in older people that are associated with a high risk of death and reduced function. The vast majority of intertrochanteric fractures require surgical treatment to withstand early mobilization and weight bearing, which prevents complications due to prolonged bed rest and aids in fracture healing.
Methods: This study is compromised by two parts, the experimental study and the clinical part. In the first part, a standard 130ο degrees nail will be used with the appropriate lag screw(s) and dynamic distal locking in synthetic osteoporotic femurs and the transmission of forces in the proximal femur, measured by a cortical surface-strain distribution, will be evaluated using digital image correlation (DIC). Finite element parametric models of the bone, the nails and their interface will be also developed. Finite element computations of surface strains in implanted femurs, after being validated against biomechanical testing measurements, will be used to assist the comparison of the nails by deriving important data on the developed stress and strain fields, which cannot be measured through biomechanical testing. In the other part, will set up a prospective, randomized, comparative clinical study among the Gamma3 and IT chephalomedullary nailing, in order to investigate if there are any statistical important differences in the main radiological measurements and functional status in closed unstable intertrochanteric fractures (A21-3) in patients aged over 70 years-old at the 24 weeks follow-up evaluation using patient reported disease specific outcomes.
Discussion: This study will be the first to compare clinical, radiological and biomechanical measurements off the two different chephalomedullary nails. Our main hypothesis is that the IT nail would provide better radiological outcome and probably better clinical results than the Gama3 nail.
Clinical Trial registration: International Standard Randomized Controlled Trial Number (ISRCTN): https://doi.org/10.1186/ISRCTN15588442, registered on 19/4/2022
Efficacy of in situ regenerative therapy in refractory orthopedic wounds in children
Authors: Chen Xiang , Fang Yu , Jiang Linjun , Chen Lian , Zheng Chao
Published: May 2023

Objective To evaluate the efficacy of in situ regenerative therapy in refractory orthopedic wounds in children.Methods Sixty children with refractory wounds admitted to our department from January 2020 to July 2021 were recruited and randomly assigned to receive in situ regenerative therapy (observation group) and vacuum sealing drainage (VSD) (control group). Outcome measures included postoperative recovery, cytokine levels, visual analogue scale (VAS), and complications.Results In situ regenerative therapy achieved significantly faster growth of fibrous connective tissue, shortened time of wound healing, as well as a higher rate of flap formation as compared with VSD (P < 0.05). The levels of IL-6/8 in wound tissues treated by in situ regenerative therapy were lower than those by VSD (P < 0.05). 83.3% of refractory wounds were treated efficiently by in situ regenerative therapy as compared with VSD(66.7%). Lower pain scores and secretion scores achieved by in situ regenerative therapy(P < 0.05).Conclusion In situ regenerative therapy is an effective technology for treating pediatric refractory orthopedic wounds, which promotes the growth of fibrous connective tissue, shortens the healing time, as well as reduces the inflammatory response of local tissues.
Robot-assisted thoracoscopic esophagectomy versus thoracoscopic esophagectomy
Authors: Xue Mengchao , Liu Junjie , Lu Ming , Zhang Huiying , Liu Wen , Tian Hui
Published: May 2023

Background
The gold standard for treating resectable esophageal cancer is esophagectomy. Robot-assisted thoracoscopic esophagectomy (RATE) is a technique that bridges the gap between open esophagectomy and minimally invasive surgery, although there is little evidence to support its superiority over traditional thoracoscopic esophagectomy (TE) in treating thoracic esophageal cancer.
Method
We included 159 patients who received TE and 35 patients who had RATE in this research after retrospectively analyzing clinical data from patients with esophageal cancer who underwent surgery at Qilu Hospital between August 2020 and August 2022. Both groups' intraoperative, postoperative, and preoperative patient characteristics were assessed.
Results
With regard to preoperative patient characteristics, all P values were greater than 0.05 in the TE and RATE groups except for height, and the preoperative characteristics of the two groups could be considered similar. In terms of intraoperative indices, there were no significant differences between the two groups in terms of TNM stage of resected tumor, tumor tissue type and ASA score. However, there were statistically significant differences between the TE and RATE groups in terms of operative time, intraoperative bleeding, total number of lymph nodes resected, and number of lymph nodes resected in the thoracoabdominal cavity. Regarding postoperative characteristics, there were statistically significant differences in pain scores on the first postoperative day and chest drainage on the first postoperative day, and there were no significant differences in the remaining characteristics between the two data groups.
Conclusion
This study confirmed the feasibility and safety of RATE for esophageal cancer by comparing it with TE. We concluded that RATE does result in more complete lymph node clearance, reduced operative time and surgical bleeding, and postoperative relief of patient pain and chest drainage. We plan to conduct the next clinical study with long-term follow-up to evaluate the tumor clearance, recurrence and survival rates after receiving RATE for esophageal cancer to investigate the role of RATE in esophageal cancer.
Deep-seated causes of behavioral problems in children with acute leukemia aged 3–12 years in western China
Authors: shen Yuqing , Mo Lin
Published: May 2023

The authors have requested that this preprint be removed from Research Square.
Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study
Authors: Taniguchi Jumpei , Matsui Hiroki , Nagai Tatsuya , Otsuki Ayumu , Ito Hiroyuki , Sugimura Hiroshi , Nakashima Kei
Published: May 2023

Background
Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection.
Methods
In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery.
Results
Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003).
Conclusions
Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection.
Trial registration:
The participants were retrospectively registered.
Exploring Hazard of Social Media Use on Adolescent Mental Health
Authors: HALIM MOHD RADZI TARMIZI A , IBRAHIM MUHAMAD ARIFF , Adib Nik Adlin Nazrin Nik Mohd , Hashim Huzaini , Omar Rosmaria
Published: May 2023

Background
Previous studies have cautioned about the negative impact of social media use on the mental health of adolescents and emerging adults. In 2021, the National Institutes of Health Malaysia emphasized the urgent need to address digital-related mental health issues, which pose a significant gap in our understanding. Nevertheless, there has been a lack of research on the effects of social media addiction on the mental well-being of local adolescents. This study aims to examine the effect of social media use on mental health issues among adolescents in Kelantan, Malaysia.
Methods
A total of 384 respondents voluntarily participated in this cross-sectional study involving ten districts in Kelantan using the snowball sampling method.
Results
Analysed data finds social media addiction correlates significantly with depression, suicide ideation and self-esteem. Multiple regression analysis indicated that suicide ideation was predicted by social media addiction and depression but not self-esteem. Furthermore, social media moderates the relationship between depression and suicidal ideation.
Conclusion
Controlling social media use may prevent addiction and promote greater mental health among adolescents.
On statistical convergence of set sequences in fuzzy anti-normed linear space
Authors: Pandit Shailendra
Published: May 2023

In this article, we have studied the fuzzy α-anti Wijsman convergence, fuzzy α-anti Wijsman statistical convergence, and fuzzy α-anti Hausdorrf statistical convergence where 0 < α < 1, of set sequences of non-empty closed sets in fuzzy anti-normed linear spaces (M, ψ, ⋄) with regard to the fuzzy anti norm(FAN) ψ. Furthermore, certain important theorems and examples based on the notion were presented.
2020 MSC: 40A05, 46S40
Synthesis and Catalytic Activity of CoMo and CoMoW Catalysts supported on γ-Al 2 O 3 for Efficient Naphtha Hydrodesulfurization
Authors: Albdiry Mushtaq , Mahdi Fouad
Published: May 2023

Bimetallic Co5Mo15 of 5 wt.% Cobalt as a promoter and 15 wt.% Molybdenum as an active metal and trimetallic Co5Mo15-xWx (x = 1, 3, 5 wt.%) heterogeneous catalysts supported on gamma alumina (γ-Al2O3) were synthesized by an incipient wetness co-impregnation process. The structural and the physicochemical characteristics of the prepared bi- and tri-metallic catalysts were evaluated by the XRD, SEM, BET and BJH, respectively. The role of third W active metal on the catalytic activity was determined through a hydrodesulfurization (HDS) reaction of naphtha at four different reaction temperatures (250, 275, 300, 325ºC) and four liquid hourly space velocities, LHSV (3, 4, 5, 6 hr-1) under constant 1.5 MPa H2 pressure. The trimetallic CoMoW5 catalyst exhibited the maximal HDS efficiency at 325ºC and 3 hr-1 liquid flow of 88% sulfur removed compared to the CoMo catalyst. This was ascribed for the role of the highly dispersed active W metal and presence of the sulfided CoMoWS and CoWS sites on the alumina surface that leads to increase the surface area and the porous structure, and enhancing the metal/sulfur bond.
Intraperitoneal injection of mesenchymal stem cells-conditioned media (MSCS-CM) treated monocyte can potentially alleviate motor defects in experimental autoimmune encephalomyelitis female mice; an original experimental study
Authors: Kondori Bahman Jalali , Abdolmaleki Amir , Raei Mahdi , Ghaleh Hadi Esmaeili Gouvarchin
Published: May 2023

Introduction: Multiple sclerosis (MS) is destructive pathology of myelin in central nervous system (CNS) leading to occurrence of physical complications. Experimental autoimmune encephalomyelitis (EAE) is the laboratory model of MS widely used for CNS-associated inflammatory research. Cell therapy using macrophage M2 (MPM2), as a cell type with anti-inflammatory feature, seems useful for EAE treatment. This study was aimed to investigate the therapeutic anti-inflammatory effects of intraperitoneal (IP) injection of MPM2 cells on alleviation of motor defect in female EAE-affected mice.
Materials and Methods: 24 C57/BL6 female mice were divided into EAE (EAE-affected mice), EAE+Dexa (EAE-affected mice receiving dexamethasone), EAE+PBS (EAE-affected mice receiving PBS) and EAE+MP2 (EAE-affected mice receiving MPM2). EAE was induced through application of spinal homogenate of guinea pigs. MPM2 cells were extracted and cultured from bone marrow and injected (106cells/ml) in three days of 10, 13 and 16 post-immunization (p.i). The clinical score (CS), anti-inflammatory cytokines, pro-inflammatory gene expression and histopathological investigations were considered. Data were assessed analyzed using SPSS software (v.19) and p<0.05 was assumed significant level.
Results: IP injection of MPM2 in EAE-affected mice can significantly (p<0.05) alleviate CS index, accelerate anti-inflammatory cytokines (IL-4, IL-10), and attenuate pro-inflammatory genes expression (TNF-α, IL-1β). These findings were also approved by histopathological tissue staining.
Conclusion: IP injection of MPM2 to the EAE-affected mice can potentially reduce the CNS inflammation, neuronal death and myelin destruction leading to the improvement of animal movement behaviors.
A new result on the long lived sunspot magnetic flux and their association with CME speed
Authors: Ibrahim M. Syed , Ebenezer E. , Raj S. Aswin Amirtha , Shanmugaraju A.
Published: May 2023

In this article, we calculate sunspot magnetic flux and look for a connection with Coronal Mass Ejection (CME) speeds. The solar activity peaked between 2011 and 2016 in Solar Cycle 24, and we gathered long-term sunspot data from the northern and southern hemispheres during this period. Long-lived sunspots will undoubtedly be associated with flare-CME eruptions. Finding the relationship between the CME speed and the sunspot’s area and magnetic field is crucial to forecast CME speed in th near-Sun environment. We used solar charts from Kodaikanal solar observatory (KSO) and the square grid method to determine the sunspot’s area. We calculated the Line of Sight (LOS) magnetic field for every long-lived sunspot using magnetogram images from SDO/HMI for various locations for all the available observation days at KSO. According to this analysis, the sunspot area and flux are found to significantly impact the fast CMEs with speed ≥1000 km s −1. In the present study concerning the classification of sunspot types, we identified that βγ has long lived group of sunspots compared to other groups. The values of logarithmic magnetic flux (sunspot area x magnetic field) can be related with CME speeds as V CME = 754.29 x log(magnetic flux)-2888. The most important factor in determining the CME speeds is the values of the logarithmic magnetic flux. At smaller logarithmic magnetic flux values (≤5 MHS G) and faster CMEs (≥1000 km s −1), the magnetic flux has a better correlation with the CME speed.
Preliminary Exploration of Structure–Function Crosstalk in Colorectal Cancer Research: Protein Structuromics
Authors: Xiao Nan , Zhang Jing , Xu Guangshuai , Pan Xin , Yang Guang , Yang Jinhua , Li Chi , Liu Kang , Li Yingxin , Chen Zhibo , Yin Chaoqun , Li Xingqi , Wang Zhina
Published: May 2023

Colorectal cancer (CRC) refers to cancer that develops from the colon or rectum (parts of the large intestine). Signs and symptoms include blood in the stool, changes in bowel movements, weight loss, and fatigue. Since 1923, when the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrenceand the underlyingmechanism. Medical doctors remain stymied regarding tumor recurrence and worsening disease after effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D structure analysis and systematic analysis of the structure‒function relationships of proteins. We hope that these analyses will help promote mechanistic research and the development of new treatments for CRC.
Biotechnological production of natural products in entomopathogenic bacteria
Authors:   , Kreling Lukas
Published: May 2023

This work characterizes the post-PKS modifications of AQ-256. Additionally, the second part describes the establishment of an AQ production platform for electrolyte generation that can be utilized in redox-flow-batteries. Lastly, a silent BGC that encodes the genes for terpenoid biosynthesis was described and characterized with regards to product formation and putative ecological function.
Women in Sport Leadership, Fifty Years Since Title IX
Authors: Brawner Candace
Published: May 2023

Women in athletic administration in secondary public schools in Texas remain a significant minority to their male counterparts despite nearly fifty years since the passage of Title IX. This qualitative research study used narrative inquiry to investigate the factors leading to success among female athletic administrators in secondary education Creswell’s (2013) method for coding information and identifying themes. The study results are organized by the four research questions.  The findings include the importance and value of professional organizations for the personal development and networking opportunities for women. Work-life balance was noted among all the participants and the executive directors of the professional organizations as the largest factor for women leaving the industry. Desirable feminine traits, experience and connections, and influential male mentors and advocates were cited by the research participants as key factors to their personal advancement. Recommendations for practical application include partnerships between professional organizations and school districts to review key concerns as they relate to the recruit and advancement of women in athletic administration. This study provides suggestions for advancing women in athletic administration in Texas school districts including: removal of barriers, opportunity for training, district environment of readiness, professional organization support, and prioritization of work-life balance and family needs.
Development and evaluation of Islamic green financing: A systematic review of green sukuk
Authors: Alam Azhar , Tri Ratnasari Ririn , Latifathul Jannah Isnani , El Ashfahany Afief
Published: May 2023

The threat of the global climate crisis demands improvement and adjustment from various sides, including the financial sector. Islamic finance responds to environmental responsibility by presenting environmentally friendly financing products in green sukuk. This study aims to show the development trend of the number of publications in green sukuk and systematize the results of studies that explain the development and evaluation of the emergence of green sukuk investments. This study analyzed 15 publications on green sukuk during the 2016-2022 years indexed by the Scopus database. As for methodology, the descriptive analysis was used to explain the green sukuk data quantitatively; the synthesis analysis was used to describe data based on four directions (the development of models (10 sources), opportunities (12 sources), challenges (12 sources), and evaluations of green sukuk (10 sources). Preferred Reporting Items for Systematic Review and Meta-Analyses standard were used to choose samples for this investigation. The green sukuk challenge is dealing with the sukuk market after the pandemic. Several evaluation findings regarding managing commitment from the government and investors for the renewable energy sector and efforts to provide low-cost sukuk financing and risk minimization are found. Green sukuk demands efficient management to be more viable, competitive, and attractive to investors if the operational area supports it. Green sukuk projects face expanding green funding, global climate financing, managing renewable energy, and validating greenhouse gas emissions. The green stock market reaction requires coordination amongst economic subsectors.
Layout Furniture in Supporting the Visually Impaired People at the Dining Area of PSBN Wyata Guna
Authors: Wasilah Deanawati Insani , Amalia Friska
Published: May 2023

The dining room at PSBN Wyata Guna is used for visually impaired people when it's time to eat in the dining room. This room has high potential complexity and level of activity. Because of the activities that occur, the movement of visually impaired persons is essential in this dining room. But the lack of treatment in the dining room causes frequent collisions and difficulties for the visually impaired person in finding directions. Therefore, we need a stimulus that can support the movement of the visually impaired person in circulation. Through previous research, stimuli that play a high role are sound and layout. This study uses an experimental method to determine how significant the layout and sound stimuli are for visual impaired person in circulation. And it has been concluded that distance is not significant to determine the time of movement in circulation in the dining room, the most important thing for people with visual impaired person is the instructions located in the area of circulation and sound stimuli which are located at critical points. The instructions referred to can be in the form of furniture or other objects if they do not inhibit circulating movements and have a consistent distance, while sound is needed to convince persons with disabilities that their direction is correct. Furthermore, this research can be a recommendation for further research, both academics and related institutions as well as input for interior designers and architects in designing dining rooms for persons with disabilities on a small scale.
Comparative study of the effectiveness of phlebotonic drugs in the experiment
Authors: Pozdnyakov D. I. , Kozlova V. V. , Karmanovich A. A. , Rybalko I. E.
Published: May 2023

Introduction. Chronic venous diseases are a common group of diseases with a significant risk of complications requiring timely correction. As a rule, phlebotonic drugs based on flavonoid complexes are used for the treatment and prevention of venous diseases.

Aim. To evaluate the effectiveness of the use of various phlebotonic drugs in the conditions of experimental chronic venous insufficiency.

Materials and methods. Varicose veins were modeled in Wistar rats by partial stricture of the deep femoral vein. The studied medicines were administered orally in a course of 30 days from the moment of surgery. During the work, the change in the following parameters was evaluated: the rate oflocal blood flow in the skin in dynamics, the degree of vascular permeability, the concentration of proinflammatory cytokines (TNF-α, IL-6) and matrix metalloproteinase 9 (MMP9) in the vascular wall. The rate of local blood flow was assessed by ultrasound Dopplerography. The change of vascular permeability was studied by the degree of extravasation of the Evans blue dye in the Miles test. The content of proinflammatory cytokines and MMR9 was determined by enzyme-linked immunoassay. The results were statistically processed.

Results. The study showed that the course oral administration of all the studied venotonizing drugs led to the restoration of hemodynamics and a significant (p˂ 0.05) decrease in the degree of vascular permeability in relation to untreated animals. It is worth noting that the use of a micronised purified flavonoid fraction 1 contributed to the development of a more pronounced vasal effect, which was reflected in an increase in blood flow velocity and a decrease in vascular permeability compared to the rest of the studied drugs. At the same time, the administration of micronised purified flavonoid fraction 1 to animals led to a statistically significant decrease in the concentration of proinflammatory cytokines, which was not observed when using other drugs.

Conclusion. The course administration of the micronised purified flavonoid fraction 1leads to the development of a pronounced phlebotonic effect, expressed in the restoration of microcirculation, a decrease of the inflammation in the vascular wall.
Hyperpigmentation after sclerotherapy: modern possibilities for prevention and treatment
Authors: Bogachev V. Yu. , Boldin B. V. , Alukhanyan O. A. , Turkin P. Yu. , Lobanov V. N.
Published: May 2023

Sclerotherapy is one of the most popular and most common techniques for the removal of delated reticular veins and telangiectasias on the lower limbs. Despite the vast pooled experience, this procedure can be accompanied by a number of undesirable side effects, of which post-injection hyperpigmentation, which frequency reaches 80%, is the most unpleasant one. The development of postsclerotherapy hyperpigmentation (PSHP) is associated with extravasation and destruction of red blood cells, which results in transformation of haemoglobin into hemosiderin pigment. PSHP is, by definition, a variant of post-traumatic hemosiderin pigmentation. The likelihood of occurrence and persistence of PSHP is determined by a number of hard controllable factors, including the calibre and location of the target veins, the type, concentration and physical form of the sclerosing agent, the sclerotherapy technique, the method and duration of post-procedural compression, patients’ ethnicity, iron metabolism disorders, concomitant use of a number of drugs, a menstrual cycle phase in women, etc. Hyperpigmentation significantly decreases the patients’ quality of life, which determines the need for the prevention and treatment of this undesirable side effect of phlebosclerosing treatment. Recommendations for prevention of PSHP include a detailed history taking aimed at identifying potential risk factors, in the presence of which it is advisable to use various systemic and topical drugs in the post-procedural period in order to prevent the skin hemosiderin deposition, as well as to apply the extended-cycle compression. In the case of PSHP, procedures aimed at the destruction and utilization of hemosiderin, such as Q-Switched laser and IPL therapy, as well as various peeling options intended to speed up the replacement of pigmented skin with normal, can be applied. For the PSHP prevention and treatment, the use of Contractubex containing cepalin onion extract in combination with allantoin and heparin is a matter of interest. Contractubex is a drug originally intended to optimize wound healing and prevent the formation of hypertrophic scars. At the same time, there is ample publications discussing the possible use of this drug for the management of post-traumatic hyperpigmentation due to the combined action of its components. Our clinical experience confirms the effectiveness of Contractubex in the treatment of PSHP, which determines the feasibility of conducting full-fledged clinical trials and accumulating more pooled experience in this area.
Determination of Trifloxystrobin in Soy Grape Juice and Natural Water by Photo-Induced Fluorescence and High-Performance Liquid Chromatography
Authors: Almeida Joseany , Macedo Rosana , da Cunha Alessandra , Toloza Carlos , Aucélio Ricardo
Published: May 2023

A fluorescent (340/380 nm) photochemical product, identified at m/z 206 by mass spectrometry was obtained by photo-derivatization (15 s ultraviolet exposure) in water/acetonitrile 10/90 v/v. The photoproduct was used for indirect determination of trifloxystrobin in water and soy grape juice by high-performance liquid chromatography and fluorescence detection. Separation was made under isocratic conditions (acetonitrile/water 70/30% v/v, at 1.0 mL min-1 and 35 °C) with trifloxystrobin photo-derivative eluting at 3.2 min. The influence of ultraviolet exposure was evaluated in short and long terms with photoproduct showing stability up to 120 min after 15 s of ultraviolet exposure. The limit of detection was 57 µg L-1 in water (87-109% recoveries). For soy grape juice, dispersive liquid-liquid micro-extraction was used to clean up and for pre-concentration (limit of detection of 9.5 µg kg-1 and 93-101% recoveries) attending to the maximum residue limits for citrus juices established by regulatory agencies. Potential interference by triazoles was evaluated.
Effects of Pasteurization and Freeze Drying on Proximal Composition, Fatty Acids Composition and Lipid Quality in Colostrum Human Milk
Authors: Ientz Gislaine , Alves Eloize , Castro Matheus , Frigo Giovana , Tavares Christyna , Visentainer Jeane , Santos Oscar , Visentainer Jesui
Published: May 2023

Colostrum human milk samples obtained from human milk banks received different treatments and were evaluated for their proximal composition, fatty acids composition and lipid quality. The total lipids content was maintained in the treatments. There was no difference in moisture, ash, total proteins, carbohydrates and energetic value for raw colostrum human milk and pasteurized colostrum human milk, and there was difference in ash, total proteins and energetic value for freeze-dried colostrum human milk and pasteurized + freeze-dried colostrum human milk. The fatty acids composition demonstrated no difference in the processes for 14 of 31 fatty acids identified. Furthermore, lipid quality indices were obtained, which were unpublished for colostrum human milk submitted to pasteurization and freeze drying. Principal component analysis showed similar behaviors for freeze-dried colostrum human milk and pasteurized and freeze-dried colostrum human milk. So, the processes used may be promising for application in colostrum human milk, due to the maintenance of its proximal characteristics and fatty acid composition.
Performance evaluation of artificial neural network model in hybrids with various preprocessors for river streamflow forecasting
Authors: Momeneh Sadegh , Nourani Vahid
Published: May 2023

Accurate forecasting of hydrological processes and sustainable management of water resources is inevitable, especially for flood control and water resource shortage crisis in low-water areas with an arid and semi-arid climate, which is a limitation for residents and various structures. The present study uses different data preprocessing techniques to deal with complex data and extract hidden features from the stream time series. In the next step, the decomposed time series were used, as input data, to the artificial neural network (ANN) model for streamflow modeling and forecasting. The preprocessors employed included discrete wavelet transform (DWT), empirical mode decomposition (EMD), complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN), successive variational mode decomposition (SVMD), and multi-filter of the smoothing (MFS). These preprocessors were used in hybrid with the ANN model to forecast the daily streamflow. In general, the results showed that the optimal performance of hybrid models has two basic steps. The first step is choosing a suitable approach to utilizing the input data to the model. The second step is to use the appropriate preprocessor. Overall, the results show that the MFS-ANN model in short-term forecasting and the SVMD-ANN model in long-term forecasting performed better than other hybrid models.
Territórios, redes e cidades
Authors: Souto Maior Fontes Breno Augusto , Furini Luciano Antonio
Published: May 2023

Há alguns anos, um renomado cientista social publicou um livro intitulado “Cidades: a urbanização da humanidade”, indicando que, com a revolução industrial, o fenômeno urbano agora significa não uma formação espacial diversa, a cidade e seu hinterland, estruturando-se consoante os múltiplos arranjos territoriais isolados. O urbano desta vez se organiza em campos reticulares complexos e articulados, espalhando-se por espaços podem até ultrapassar as fronteiras político-administrativas dos Estados nacionais. As redes territoriais que estruturam as cidades sobrepõem-se aos arranjos tradicionais das cidades, entrincheiradas em suas peculiaridades espaço-temporais. 

As dinâmicas entre redes territórios e cidades guardam, por um lado, uma série de divisões (da produção, do trabalho, da distribuição, do consumo, entre outras), que conferem sentido ao modo como a rede urbana é hierarquizada segundo os papéis das cidades. Por outro lado, expressa inúmeras formas de interações socioespaciais, articuladas por diferentes tipos de redes sociais, técnicas e urbanas, que permite identificar graus de heterarquia nas redes urbanas contemporâneas, relativizando a estrutura hierárquica anterior. Nesse sentido, é a lógica das redes que potencializa as novas formas de interações urbanas.
Entrapment of Digoxin-KLH Conjugate in Alginate/Chitosan Nanoparticles:
A New Antigen Delivery System For Production of Anti-digoxin
Antibodies
Authors: Javid Nazli Kashani , Dounighi Nasser Mohammadpour , Arbabi Bidgoli Sepideh
Published: May 2023

Background:

Nanoparticles have received more and more attention in the vaccine and drug delivery systems field due to their specific properties. In particular, alginate and chitosan have been known as the most promising nano-carries. Digoxin-specific antibodies effectively manage acute and chronic digitalis poisoning using sheep antiserum.

Objective:

The present study aimed to develop alginate/chitosan nanoparticles as a carrier of Digoxin-KLH to promote the immune response by improving the hyper-immunization of animals.

Methods:

The nanoparticles were produced by the ionic gelation method in mild conditions and the aqueous environment, which leads to the production of particles with favorable size, shape, high entrapment efficiency, and controlled release characteristics

Results:

The synthesized nanoparticles of 52 nm in diameter, 0.19 in PDI, and -33mv in zeta potential were considerably unparalleled and characterized by SEM, FTIR, and DSC. Nanoparticles resembled a spherical shell, smooth morphology, and homogeneous structure shown by SEM images. FTIR and DSC analyses confirmed conformational changes. Entrapment efficiency and loading capacity were 96% and 50%, respectively, via direct and indirect methods. The invitro conjugate release profile, release kinetics, and mechanism of conjugate release from the nanoparticles were studied under simulated physiological conditions for various incubation periods. An initial burst effect revealed the release profile, followed by a continuous and controlled release phase. The compound release mechanism from the polymer was due to Fickian diffusion.

Conclusion:

Our results indicated the prepared nanoparticles could be appropriate for the convenient delivery of the desired conjugate.
Firm size moderate the effect of audit quality and managerial ownership on investment efficiency
Authors: Darmayanti Pande Putu Biantari , Wirama Dewa Gede , Sudana I Putu , Sari Maria Mediatrix Ratna
Published: May 2023

This study aims to examine the effect of audit quality and managerial ownership on firms' investment efficiency. In addition, this study also aims to investigate the effect of firm size in moderating the effects of audit quality and managerial ownership on investment efficiency. The population of this study is manufacturing sector companies listed on the Indonesia Stock Exchange (IDX). Using a sample of 162 companies in 2019-2021, 486 observations were obtained. This study used logistic and moderated regression analyses (MRA) with Eviews 12 software for data analysis. The results show that audit quality does not affect investment efficiency. Managerial ownership affects investment efficiency. Firm size does not moderate the effect of audit quality on investment efficiency. Firm size can strengthen the effect of managerial ownership on investment efficiency.
Влияние морфологии поверхности и границ раздела на продольную фононную теплопроводность в тонкопленочных структурах Ge(001) и Si/Ge(001)
Authors: Хомец А.Л. , Сафронов И.В. , Филонов А.Б. , Мигас Д.Б.
Published: May 2023

In this work the method of non-equilibrium molecular
dynamics was used to study the longitudinal phonon thermal
transport at 300 K in nanoscale homogenous Ge(001) and lay-
ered Si/Ge(001) thin films with p(2 × 1) surface reconstruction
along different directions. The appearance of thermal transport
anysotropy in the films under consideration, which is due to
both the surface morphology and sharp Si/Ge interfaces, has been
established. For the direction when the dimers and Si−Ge bonds at
the interface lie in a plane parallel to the direction of the heat flow,
the lowest thermal conductivity is observed (∼ 5−18 W/(m · K)
in the range from ∼ 1 to 27 nm). It is shown that for films
with thicknesses of more than 13 nm for all directions, layered
films have a lower thermal conductivity compared to homogenous
ones. In this case, the role of the surface morphology and
interfaces is reduced to different degrees of phonon localization
and compensation for more heat-conducting Si layers, respectively.
Микроволновая вольт-импедансная спектроскопия полупроводниковой структуры
Authors: Резник А.Н. , Востоков Н.В.
Published: May 2023

Microwave voltage-impedance spectroscopy is used to study a semiconductor structure in the form of a doped n-GaAs film grown on a conducting n+-GaAs substrate with a buffer sublayer. A system of concentric barrier contacts is formed on the structure surface. A technique has been developed for measuring complex impedance spectrum Z(f,U) of the sample as a function of DC bias voltage U. Spectra Z(f,U) were measured using a Cascade Microtech probe station in the frequency range 0.01 – 40 GHz with a lateral resolution of 15 – 30 μm at U = 0 – 10 V. The main electrophysical characteristics of a semiconductor film were determined from the spectra: type, concentration and mobility of free charge carriers, electrical conductivity. An excess resistance was found in the range f = 0.1 – 20 GHz. This effect is interpreted as the deep states (traps) recharging for two types of traps – low-frequency l and high-frequency h with characteristic time τl = 10^(-9) s, τh = 4.2∙10^(-11) s. A model description is proposed that explains the characteristic shape of the trap resistance spectrum, its dependence on the contact area and voltage U.
Моделирование зонной структуры сверхрешеток на основе "разбавленных" нитридов
Authors: Дашков А.С. , Костромин Н.А. , Бабичев А.В. , Горай Л.И. , Егоров А.Ю.
Published: May 2023

The paper describes an algorithm for computing the interband transition energy for superlattices of quaternary solid solutions of diluted nitrides. Using the described method, the authors have conducted several numerical simulations of test structures with InGaAsN quantum wells for the method verification using experimental data and comparison with other approaches. Simulation results showed the validity of the used approach. The hybridization parameter estimation method for Indium mole-fraction below 30 % is presented. Based on simulation results, the authors propose InGaAs/GaAsN superlattices' parameters for the implementation of the source emitting in the 1.3 µm spectral range.
Plataforma de información genómica de la raza Cebú Brahman:para uso en selección y mejoramiento genético
Authors:   Corporación Colombiana de Investigación Agropecuaria, Bogotá (Colombia)
Published: May 2023

Acelerar la ganancia genética a través de la evaluación genómica, utilizando la información contenida en el ADN de los animales, con el ﬁn de incrementar los índices de producción en un menor tiempo.
Enfermedades de las abejas: Varroa destructor
Authors: Vásquez Romero Rodrigo Efrén , Cepeda Granados Mónica
Published: May 2023

El acaro Varroa destructor afecta todos los estadios de las abejas obreras y zánganos. El agente infeccioso es la hembra adulta de manera forética (adherica a la abeja).
Enfermedades de las abejas: Pequeño escarabajo de la colmena
Authors: Vásquez Romero Rodrigo Efrén , Cepeda Granados Mónica
Published: May 2023

El pequeño escarabajo de la colmena -PEC llega por vuelo propio, por huevos adheridos a las abejas o por equipo de manejo contaminado. Su larva se alimenta y defeca en los panales de cría y alimento, generando perdida de la miel e incluso el abando de la colmenta por parte de las abejas.
Sistema de información de suelos del altiplano Cundiboyacense – IRAKA
Authors: Varón Ramírez Viviana Marcela , Gómez Latorre Douglas Andrés , Martínez Maldonado Fabio Ernesto , Silva Arero Elías Alexander
Published: May 2023

El conocimiento del recurso suelo permite orientar prácticas de manejo y desarrollo de la agricultura de forma sostenible, lo que permite ejecutar acciones encaminadas a garantizar la seguridad alimentaria de un territorio (Ramos et al., 2018). Estas acciones deben basarse en información estructurada de suelos, información que por lo general no se encuentra compilada ni homogenizada, (Malone, Minasny & McBratney, 2017). Esfuerzos de compilación y disposición para consulta de la información edáfica han sido realizados (p. ej. SISLAC, SIGA, entre otros), sin embargo, Ramos et al. (2018) resalta la importancia de hacer uso de esa información para conocer el patrón de comportamiento de las propiedades del suelo, pues en mapas convencionales (delimitaciones hechas con polígonos) no son evidentes las complejas relaciones entre sus propiedades (Sánchez et al., 2009). Por tanto, el objetivo del presente proyecto fue construir un sistema de información de suelos en el altiplano cundiboyacense que compilara la información disponible y donde los usuarios pudieran consumir servicios web geográficos (SWG) producto del análisis y modelación de dicha información.
Cariniana pyriformis Miers growth in two light environments in Antioquia, Colombia
Authors: Pulgarin Díaz John Alexander , Cano Gallego Lucas Esteban , Gil Restrepo Juan pablo
Published: May 2023

Cariniana pyriformis is a valuable forest species in South America wood market. Its wood is appreciated for its durability and versatility and used for sawn timber, veneer, light and heavy construction and furniture manufacture. Very few plantations of the species are established in Colombia. The species is harvested in natural forests, in spite of being in critical danger of extinction (Cardenas & Salinas, 2006). There is a substantial lack of information about the growth of Neotropical forest species which constitutes the first steps to develop the fprestry sector.
Growth temperature and UVB radiation stress responses in Metarhizium anisopliae strain CPMa1502
Authors: Quiroga Ginna , Jiménez Ana , Montes Luis , Bustillo Alex , Goméz Martha
Published: May 2023

The oil palm is an economically important crop due to its high productivity and broad industrial applicability (Sabate 2016). In Colombia, this crop is grown in di erent agro-ecological zones (Borrerio 2018) where the environmental conditions are favorable to several insect pests. One of the most economically important pests is the fruit scraper Demotispa neivai (Bondar, 1940) (Coleoptera: Chrysomelidae) (Aldana et al. 2004). To control this pest, CENIPALMA isolated in Colombia (Barrancabermeja), and selected the strain of Metarhizium anisopliae CPMa1502 as a new active principle for biological control because it showed the highest mortality on adults of D. neivai (87.7%) on laboratory conditions (Aldana et al. 2004, Bustillo, 2014; Montes et al. 2016). Temperature and UVB radiation are factors that can a ect the mass production and biocontrol activity of the fungus. The evaluation of its in uence is an important part of the development of a future bioproduct. This work evaluated the conidia tolerance to di erent stress conditions of temperature (20, 25, 30, 35°C) and several exposure times of UVB radiation, measuring conidial vigor and germination, cellular viability, and radial growth rate.