bluuebunny/crossref_metadata_2025 huggingface dataset:
“Effectiveness of Planned Demonstration on Aseptic Medical Wound Dressing in Terms of Practice among Staff Nurses in Selected Hospitals of Gwalior”
Authors: Manisha Shrivastava  , Anil Singh Bhadouria  , Tanima Verma  , Ruby Singh
Published: November 2022

Background: Wound dressing procedures are very common and if wound contamination is limited, then there is a less chance of infection. The investigator felt a strong need to conduct a planned demonstration on aseptic wound dressing technique which would help the staff nurses to develop proper practice and skill in aseptic wound dressing. The aim of the study was to determine the practice on aseptic medical wound dressing technique among staff nurses before planned demonstration as measured by an observation checklist and evaluate the effectiveness of planned demonstration in terms of practice of aseptic medical wound dressing technique among staff nurses.Materials and Method: A quasi experimental, time series design was adapted for the study. The conceptual framework of the present study was developed by the investigator based on the Weidenbach’s Prescriptive Theory. Purposive sampling technique was used to select the XI samples consisted of 30 staff nurses based on their inclusion criteria. A structured observational checklist consisted of 51 items was used to evaluate the effectiveness of planned demonstration on aseptic medical wound dressing technique.Results: In pre- test majority (66.7%) of the staff nurses have an average practice on aseptic medical wound dressing where as in post test 1, majority (96.7%) of the staff nurses have good practice and in post test 2 (100%) and post test 3 all (100%) the staff nurses have good practice on aseptic medical wound dressing. The mean post-test 1 (44.5±4.2), post test 2 (48.7±0.93) and post test 3 (48.7±0.93) practice scores are higher than pre-test practice score (21.5±5.5). The calculated t value (33.3) is greater than table value (t 29=2.262) at 0.05 level of significance. There is a significant association of source of knowledge of staff nurses with pre-test practice scores and there is no significant association found between age, sex, education, years of experience and present area of working with pre- test practice scores. Also there is no significant association found between age, sex, education, years of experience, present area of working and source of knowledge with post- test practice scores.Conclusion: The findings of the study proved that the planned demonstration on aseptic medical wound dressing is an effective measure to improve the staff nurses level of practice. The nurses can learn about the aseptic measures maintained during dressing preparation phase, dressing execution phase and post procedure phase.
SARS-CoV-2, Virology and Pathogenicity and phytomedicinal immunomodulators to curb covid-19 pandemic
Authors: Sanjeev Kumar
Published: November 2022

The new coronavirus, COVID-19 has sent the world into a medical and economic crisis and if not contained can cause unprecedented damage to the human population.COVID-19 is a new pathogen and a new coronavirus that poses a global threat to healthcare system worldwide and has already devoured many lives in different parts of the world. Till date, there is no specific vaccine or effective antiviral therapy against COVID-19 disease. The only way to prevent oneself is to maintain social distancing, maintain proper hygiene and simultaneously enhance the individual’s immune response by incorporating immune boosters in daily diet, as health supplements and prophylaxis. Phytotherapy (herbalism) means usage of plants or herbs as medication to treat or prevent diseases and has a lot of potential. This phytomedicinal therapeutic approach proves to be cheaper and safer alternative and reduce the incidence of drug resistance and may modulate the immune system in preventing viral diseases. This traditional therapy has less side effects and bestow a general good health. It may suppress viral replication and reduce the clinical signs of viral diseases and can be promoted as immunomodulator. COVID 19 has been shown to engage the host cell ACE2 through its spike protein receptor binding domain (RBD) and natural phytochemical from plants have distinct effects on viral RBD and host ACE2 receptor complex. The present paper aims to present a comprehensive study of certain medicinal herbs to increase the immune potential and a promising option in the fore-front in healing COVID-19 ailments, concurrent with ICMR prescribed allopathic treatments.
A STUDY ON APPROPRIATENESS OF PACKED RED BLOOD CELLS TRANSFUSION IN A TERTIARY CARE HOSPITAL
Authors: Divya Rao  , Shalini N  , Bhagya S  , Pallavi
Published: November 2022

Blood is scarce resource that can be used for saving lives. The goal is to provide this resource appropriately for the specific deficiencies. The main aim of the study was to assess the appropriateness of packed red blood cells in various departments of a tertiary care hospital.METHODS: A total of 1000 patients were included in the study. A structured excel sheet was made to analyze the various parameters that indicate the appropriateness of PRBC Transfusion. Statistical analysis was done using statistical software.RESULTS: The study showed that there was quite higher rate of appropriateness in the transfusion. Out of 1000 patients who had undergone transfusion of 1-unit PRBC,952 transfusions were appropriate in which 776 episodes were considered appropriate as the hemoglobin levels are less than or equals to 8gm/dl. Hence, a total of 95.2% of transfusion was appropriate.CONCLUSIONS: The overall rate of appropriate PRBC transfusion was quite higher 95.2%. Continuous medical education and practices among doctors and staff can maintain this rate and help in providing quality services to patients.
A STUDY ON WORK LIFE BALANCE OF MARKETING PROFESSIONALS OF PHARMACEUTICAL INDUSTRY
Authors: Alcides Bernardo Tello  , Maryam Arshad  , Komal Khalid  , Khushbu Agarwal  , Linda Xavier
Published: November 2022

Keeping a work-life balance isn't so particularly key as it shows up. In the corporate world, change is unavoidably certain. The impact of globalization has moreover propped these changes. The corporate world is the exemplification of deficiencies, piles of liabilities, and long working hours. These advancements in the environment upset the balance between the home and work-life of the trained professionals. The rising test and mentioning of the overall people has also disturbed the situation. Everything adds up to the burnout.
ANTIULCER, ANALGESIC AND HEPATOPROTECTIVE ACTIVITIES OF HYDROALCOHOLIC ROOT EXTRACT OF JURINEA DOLOMIAEA BOISS
Authors: Priya Darshan  , Ashutosh Singh  , Abhishek Singh  , Akhilesh Singh
Published: November 2022

The herb Jurinea Dolomiaea Boiss, which is a member of the Astraceae family, has long been used in Ayurveda to treat liver diseases and as an anticancer, antioxidant, and anti-diabetic. The antiulcer, analgesic, and hepatoprotective effects of Jurinea dolomiaea Boiss aqueous and hydroalcoholic root extracts against carbon tetrachloride-induced hepatotoxicity in albino wistar rats were investigated in this work. The experimental rats were given Jurinea dolomiaea root hydroalcoholic extract (100 mg/kg and 200 mg/kg p.o.) daily for seven days. By measuring SGOT, SGPT, ALP, and total bilirubin, the hydroalcoholic extract of Jurinea dolomiaea roots was examined for its hepatoprotective properties. The toxic effect of carbon tetrachloride was greatly reduced in the rats treated with the hydroalcoholic extract of Jurinea dolomiaea roots by restoring the elevated levels of SGOT, SGPT, ALP, and total bilirubin compared to the toxicant control. Jurinea dolomiaea root hydroalcoholic extract shown notable hepatoprotective effects.
CUSTOMER PERCEPTION WITH RESPECT TO ONLINE FOOD DELIVERY
Authors: K.S Sachin  , Smita Kavatekar
Published: November 2022

The development in internet and E-business has boosted the usage of food delivery channels. In today’s generation more people are getting connected through mobile applications and are using these apps to trade. Traditional business strategies are being changed to new online marketing strategies to meet the customer needs and preferences. The internet is used to advertise and market new products; this gives customers a large variety of products or services to choose from. This study aims for the discussion about the customer perceptions over food delivery system, that too online in Bangalore. 224 respondents were taken to conduct the study. This research is focused to study and analyze those customers who are already using different portals of online food delivery.
DUAL ROLE OF MATERIALISM ON LIFE SATISFACTION: A STUDY ON MIDDLE-AGED MALES
Authors: Sneha Nathawat  , Arpita Singh  , Prerna Sharma  , Gitika Chaudhary  , Ranu Jain
Published: November 2022

The purpose of the study was to assess the relationship between Success Materialism and Happiness Materialism and show how these two dimensions of materialism influence an individual’s life satisfaction. The sample consisted of 80 males in the age range of 40-50 years with annual income of 8-10 lakhs INR. The tools used in the study were Satisfaction with Life Scale by Diener, Emmons, Larsen, and Griffin and Material Value Scale by Richins and Dawson. The results were analyzed using statistical tools for correlation and regression. The results indicated that happiness materialism has a significantly negative correlation with life satisfaction(r=-0.339,p<0.01). Success materialism and happiness materialism together contribute 9.4% variance in predicting life satisfaction, found to be significant at 0.01 level. The study concluded that happiness materialism can lead a person to be dissatisfied with their current standard of living and other pleasures of life which in turn negatively influence overall life satisfaction.
ESTIMATION OF GROWTH IN SOME BLUE-GREEN ALGAE
Authors: Vivek Singh  , Abhishek Singh  , Akhilesh Singh  , Ashutosh Singh
Published: November 2022

Physiological characterization show that all the strains have more growth in nitrogen enriched medium compared to nitrogen deficient medium. The growth measurement in terms of dry weight indicated that genus Westiellopsis has produced the maximum biomass. Therefore it has more growth rate and minimum generation time.
IN VITRO ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF ISOLATED FLAVONOID FROM METHANOLIC EXTRACT OF ANDROGRAPHIS ECHIOIDES LEAVES
Authors: Priya Darshan  , Ashutosh Singh  , Abhishek Singh  , Akhilesh Singh
Published: November 2022

The objective of this investigation was to identify the active flavonoid present across the entire Andrographis echioides plant. Using a methanolic extract from the leaves of Andrographis echioides, it was examined how flavonoids may be isolated from a plant component. Phytochemical analyses revealed the presence of flavonoid components in methanol extract. The recovered flavonoid component was further purified by column chromatography and TLC. The structures of the isolated compounds were characterized using UV-visible, FT-IR, 1H & 13C NMR and mass spectroscopy. This led to the isolated compound being given the name 9-methoxy-6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-ol or medicarpin. Further biological investigation is needed for the isolated flavonoid discovered in this plant. Recent research has concentrated on the role of flavonoids as antioxidants when oxidative stress is present. The antioxidant properties of flavonoids were also discussed.
Hyaluronic filler for lip augmentation and scar correction in cleft lip Egyptian patients
Authors: Aida Mossaad  , Amr Kotb  , Wael Ghanem  , Ibrahim Norwali  , Monther Alsharif  , Yassmeen Salaheldin Ragheb
Published: November 2022

Objectives: The goal of the current study was to assess how hyaluronic acid dermal filler was applied and how well it worked to conceal lip abnormalities after surgery in a group of Egyptian cleft lip and palate (CLP) patients.Methods: This research included sixteen female patients with unilateral lip scars between 15 and 20 years of age. Hyaluronic acid dermal filler (HADF) was injected with needle in upper lip at the scar site. Evaluation was done clinically and by digital photography before and after the procedure. Visual Analog Scale (VAS) from (0-10) was used as a patient satisfaction assessment survey. Follow up period was made one week and one month post injection.Results: All these patients noted a significant improvement in their lip scars following HA filler injection with better psychological state. The VAS satisfaction rate assessment was high and ranging from 7-9 with a mean of (8.0 ± 0.9). Clinical observation showed no long-term complications, however patients complained of some discomfort due to fibrosed tight lips during the injection.Conclusion: HADF is a safe noninvasive temporary method used for masking cleft lip scars and restoring vermilion border volume which promotes the appearance and psychological status of the CL patient.
PREFERENCES FOR PHYSICAL EDUCATION AND SPORT ACTIVITIES AMONG THE YOUNG PEOPLE ON UNIVERSITY CAMPUS
Authors: Valentine Ivashova  , Evgeniy Tufanov  , Inna Kravchenko  , Olga Shmatko  , Svetlana Yurchenko
Published: November 2022

This article presents the results of a study that aims to explore students’ preference for sport activities on campus. Based on a theoretical analysis of scientific publications, the preferences of modern youth for sports activities and possible proposals for their implementation on campus were identified. A survey was conducted among 1688 students of Stavropol State Agrarian University. Based on this survey, the conditions that affect the involvement of young people in sport activities on campus were identified using statistical procedures of factor analysis. The circumstances that cause students to skip sport activities were also identified. The data obtained during the empirical part of the study allows for informed planning of the development of sports activities on university campus. A research strategy and methodological tools were developed that allow us to study the possibility of implementing sports activities in municipal educational institutions, and in organizations of higher and secondary vocational education.
TEMPLATE SYNTHESIS OF NI(II) MACROCYCLIC COMPLEXES: CHARACTERIZATION AND BIOLOGICAL ACTIVITIES
Authors: Reetu Singh
Published: November 2022

Ni(II) complexes of Schiff’s base macrocyclic ligands i.e. 2,3,9,10-tetraphenyl-1,4,8,11- tetraazacyclotetradeca-1,3,8,10-tetraene (BDP), 2,4,10,12-tetramethyl-1,5,9,13 tetraazacyclohexadeca-1,4,9,12-tetraene (ADP) and 2,3,9,10-tetramethyl-1,4,8,11 tetraazatetradeca-1,3,8,10-tetraene (DDP) have been synthesized. All these synthesized complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility measurement, IR and UV-Visible spectral studies. On the basis of elemental analysis, the complexes have been found to have the general composition Ni(Lig)X2 where Lig = BDP, ADP, DDP and X = Cl-, SO42- and NCS-. Molar conductance of complexes has been measured in DMSO solvent and the obtained values indicate non-electrolytic nature of all complexes i.e. counter ions are present inside the coordination sphere. Magnetic moments and electronic spectral data suggested six coordinated octahedral geometry for the Ni(II) complexes. The ligand field parameters have been calculated for metal complexes by using various energy level diagrams. In vitro synthesized complexes have been examined against the growth of the some plant pathogenic fungi in order to assess their microbial properties.
Burnout among preventive residents in Saudi Arabia
Authors: Bayan Saleh Binsaeed  , Salman M. Alsubhi
Published: November 2022

Background: during emergencies, most of the doctors are supposed to suffer from burnout showing psychological and emotional stress.Objective: this study is determined to assess the prevalence and determinants of burnout among preventive residents at Makkah.Methods: A cross-sectional study that was conducted through an online questionnaire sheet. Study population and sample size: The study included 170 residents from preventive department. The questionnaire consists of five sections demographic and background variables, the level of burnout, professional factors affecting burnout, work and activity characteristics and burnout during Covid-19 pandemic. Results: About 48.35% of residents suffered from physical exhaustion, 54.59% suffered from emotional exhaustion, and 40.72% always felt weak and susceptible to illness. Burnout was much greater among younger age and lowest among older age. Conclusion: the workload of preventive residents has grown significantly during the epidemic. Burnout and stress are significant difficulties for residents and that a variety of variables influenced the rate of burnout throughout the pandemic.
Prevalence of osteoporosis in patients with chronic liver disease (CLD) in a hospital; a cross-sectional study
Authors: Faisal Moin  , Rizwan Qasim  , Moona Ashraf  , Kamran Qasim Ali
Published: November 2022

Patients with chronic liver disease (CLD) are increasing aware of the consequence of osteoporosis. Low bone turnover, impaired osteoblast function, and low blood osteocalcin levels are the hallmarks of osteoporosis in CLD, which mostly affects trabecular bone. Osteoporosis is the public health issue of metabolic bone disease among the every age group throughout the globe especially in Pakistan. The current study was conducted in DHQ, KPK, Pakistan to determine the prevalence percentage of osteoporosis in patients during July 2020-2021. Out of 548 patients, the prevalence of osteoporosis was 22.9% at a 95% Confidence Interval (5.9-12.5%), which was higher among female (57.60%) than male (42.40%). The higher prevalence rate was recorded in old patients than young patients. The lower weight, height and cholestasis in sex are risk factors of osteoporosis in chronic liver disease. The early detection of disease can help in decreasing the socio-economic burden and fracture rates.
Oropharyngeal Angioedema due to Nifedipine Hypersensitivity Post-hemithyroidectomy
Authors: Jamaludeen Abdo Othman
Published: November 2022

Nifedipine, a calcium channel blocker, is generally considered as safe but sublingual administration of immediate release nifedipine (IRN) formulations are sometimes associated with serious side effects. An 82-year-old male was presented with oropharyngeal angioedema, with no history of similar episodes, allergy to drug or food. The symptom began 20 minutes after IRN administration. He was admitted to ICU and a protective endotracheal intubation was performed. Over the first six days, his tongue continued to swell, starting with the right side, progressing to the left, hypopharynx, and epiglottis. Intravenous infusions of prednisolone, diphenhydramine and famotidine, were initiated; however, without improvement. The patient received nanofiltered Berinert® 2000 IU IV, but no improvement. Edema of the tongue reduced slowly after the seventh day and further improved over the next five days. Careful evaluation indicated nifedipine as the chief etiology for angioedema in the patient. IRN may triggers severe hypersensitivity and oropharyngeal angioedema, requiring immediate special care and thus should be used carefully.
Enhancing the Bioavailability of Quercetin by Concomitant Administration with Enzyme Inhibitor
Authors: Hayder Mohammed Abdulhameed  , Jubran K. Hassan  , Hayder Alwafi  , Shahad M. Alzobai
Published: November 2022

Background: Quercetin is a food supplement with multiple biological activities including antihypertensive, vasodilator effects, antiobesity, antihypercholesterolemic, antiatherosclerotic and other activities, it is available in wide range of dietary supplement and daily food intake, after oral ingestion, quercetin is metabolized by intestinal enzymes and absorbed by the duodenum, then be transported to the liver where is transformed into its glucuronidated, methylated and sulfo-substituted metabolites.Aim of Study: Boosting the bioavailability of Quercetin by enzyme inhibitor effect of ketoconazoleMethod: 10 apparently healthy adult, male (5) and female (5) were grouped A and B, with a 1-week wash-period, Group A received Quercetin 1000 mg, group B received Quercetin 1000 mg and Ketoconazole 400 mg, and 15 blood samples are collected on the following timing 0, 0.5 - 12.5 by 1 hour interval and other by hour 24 for HPLC Assay.Results: Concurrent ketoconazole administration with Quercetin significantly improves the mean plasma concentration under the curve from zero time to infinity (AUC0–∞) by 176% (403.41 ± 62.28 vs. 228.51 ± 28.67 μg.h/mL; P <0.0001) and prolonged time to complete elimination (44.66 ± 9.17 vs. 12.93 ± 1.4 hr.; P <0.0000) compared with Quercetin alone.Conclusion: Bioavailability of Quercetin will be increased by its administration together with ketoconazole, due to enzyme inhibiting effect of ketoconazole which delay elimination and increase the AUC of Quercetin.
GROUP THEORY CONCEPTS IN MOLECULAR SYSTEMS
Authors: P.Chinnaraj  , R. Perumal
Published: November 2022

In this work, we explore group theory ideas implemented to biology and in selective systems of biology. Symmetry performs a notable role in biology of bilaterians over radially symmetric bodies. The distinction between living and non-living organisms is best known. We concentrate on the group theory and abstract algebra covering the biology of molecular systems. We provide the applications of group theory to cancer cells. We review applications to the cells cycle and explore how cells growing and forming cycles. We applied group theory to Cancer Cells and present example to support the validity of the article.
ANALYSIS OF SURGICAL SITE INFECTION IN CAESAREAN SECTION
Authors: Krunali Mistry  , Latika Mehta  , Shilpa Gupta  , Darshil Prajapati
Published: November 2022

Globally there is increase trend in caesarean section. Current rate of CS in India has increased from 8.5% in 2005-06 to 21.5% in 2019-20.[NFHS5]. WHO guidelines have recommended a CS rate of 15%. Caserean sections can lead to many significant complications; one of these critical complications is Surgical Site Infection (SSI) [who] according for 38% of hospital acquired infection.
Evaluation of Antidiabetic activity of the marine gastropod, Turbinella pyrum from Gulf of Mannar, India
Authors: Esther Elsie. T  , Jenivi A  , R. D. Thilaga
Published: November 2022

Diabetes mellitus is a chronic metabolic disorder and is becoming the world’s third “killer” together with cancer, cerebro and cardiovascular diseases due to its wide spread prevalence, morbidity and mortality. Modern anti-diabetic agents produce undesirable adverse effects. As a result, alternative therapy is required. A shift towards marine natural products is desperately needed. Hence, this research was carried to examine the antidiabetic activity of methanolic extract of Turbinella pyrum. Alloxan was induced to get experimental diabetes animals in albino rats. A comparison was made between the action of methanolic extract of Turbinella pyrum extracts and a known antidiabetic drug glibenclamide (600 μg/kg body wt). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The diabetic rats were randomly divided into four groups (n=6/group). Group I served as control and received distilled water. Group II served as standard (Glibenclamide 600μg/kg). Group III and IV received the methanolic extract of Turbinella pyrum at a dose of 200mg/kg and 400mg/kg respectively. Maximum effect was observed at 3 hours with the low (200 mg/kg) and high (400 mg/kg) doses of methanolic extract of Turbinella pyrum which exerted more pronounced effects (87.33mg/dl and 57.17mg/dl). The effects of methanolic extract of Turbinella pyrum were more than that of the standard drug glibenclamide. Treatment of diabetic rats with the methanolic extract of Turbinella pyrum improved the body weight that is 15.49g and 16.75g at 200 and 400mg/kg doses respectively. The glibenclamide treated diabetic rats also showed improved body weight (13.88). These results demonstrate significant antidiabetic potential of the methanolic extract of Turbinella pyrum (p<0.01) and can be used for drug production in pharmaceutical industries.
STRESS AND QUALITY OF LIFE AMONG FATHERS OF SPECIAL NEEDS CHILDREN IN KLANG VALLEY
Authors: Lim Pei Tien  , Nur Atiqah  , Nathan Vytialingam  , Rashid MA  , Mohammed Shahjahan Kabir  , Farzana Y  , Nirmala P  , Lubna Shirin  , Sergey Gupalo  , Nazmul MHM
Published: November 2022

Many research articles have studied the conflicts and stress experienced by parents and mothers of special needs children with different disability such as autism, cerebral palsy, learning disabilities, down syndrome and others. Unfortunately, there are lack of study focusing the experiences of Malaysian fathers of special needs children. This study aimed to examine the stress level using Parental Stress Scale (PSS) and quality of life (QOL) using WHOQOL-BREF, a short version of QOL and to study correlation between stress and quality of life. Two hundred and fifty-six (n=256) samples included fathers of special needs children (n=128) and fathers of typical children (n=128) were recruited into this cross-sectional study from centers or schools in Klang Valley. A set of questionnaire containing 3 sections were distributed via hard copies and online survey. Section 1 comprised father’s demographic data and child’ demographic data and Section 2 was a questionnaire Parental Stress Scale (PSS) to assess stress of fathers and Section 3 was WHOQOL-BREF questionnaire to examine the quality of life of fathers. The demographic data, PSS score and WHOQOL score was analysed using descriptive analysis. Meanwhile, Pearson r was used to identify the correlation between stress and quality of life of fathers of special needs children. The findings of the study showcased that fathers of special needs children have higher mean stress level (M=44.50) and lower quality of life (M=14.16) and where else, fathers of typical children has lower stress level (M=39.70) and higher quality of life (M=15.41). The Person r correlation test indicated moderate negative correlation between stress and quality of life (QOL) of fathers of special needs children, r= .328, p<0.01, two-tailed, n=128. Higher parental stress indicated lower level of sensitivity and poorer quality of parental-child relationship.
ASSESSMENT OF WATER QUALITY FOR IRRIGATION USING THE SUB-INDEX MODEL: ACASE STUDY OF TIGRIS RIVER WATER IN MOSUL CITY, IRAQ
Authors: Mohammed A.A. Al-Soyffe  , Yusra M. S. Al-Shaker  , A.Y.T. A. Saffawi
Published: November 2022

The purpose of this research was to use mathematical models to evaluate Tigris River water quality in the metropolitan area of Mosul (WQI). Starting in November 2021 and continuing through March 2022, researchers will collect 120 water samples from six different locations along the Mosul River before it enters the city of Mosul at Badush Kasbah, north-east of the city, all the way down to the Yarmajeh area, south of Mosul (at a rate of two repeats per month for each site) in order to conduct physical and chemical analyses. In addition, the water quality for irrigation was assessed using the (Sub-index-WQI) model and the Kelly Index, K.R., both of which adhere to internationally accepted standard techniques.According to the results of the study, majority of the standards utilized fell within the acceptable range for Irrigation as defined by (WHO, 2004), as shown by the values of the sub-index index falling somewhere in the (44.82-46.12). Because of this, the Tigris River in Mosul City has a high enough quality to be used for irrigation.
Evaluation of the activity of trans-Resveratrol alone and in combination with Amlodipine and Pioglitazone against Fructose induced metabolic syndrome rats
Authors: T. Anila  , A. Sudheer  , B. Mary Vishali  , K. Somasekhar reddy  , I. Sai Reddemma  , S. Akkulanna  , M. Sri Ramachandra  , Khusali soni
Published: November 2022

Metabolic syndrome (MS) is a cluster of conditions that cause an increase in the risk of diabetes, heart disorders, and stroke.The present research was completed in Wistar rats, in which Metabolic Syndrome (MS) was induced with a High Fructose Diet. Animals were randomly divided into 7 gatherings and the test group animals received Resveratrol (RSVT), Amlodipine (AML), Pioglitazone (PIO), Resveratrol+Amoldipine, and Resveratrol+Pioglitazone at different doses for 5 weeks. Various behavioral, biochemical, and histopathological parameters were estimated.AML alone and along with RSVT was found to reduce diastolic and systolic pressures, there was the reduction in BP in the remaining groups. There was a significant reduction in serum insulin and Fasting glucose level (FGL) in all the treatment groups. And there was a noticeable reduction in the levels of total glycerides (TG), total cholesterol (TC) along with LDL, HDL, and VLDL when compared to the control group and HFD group. Histopathological study revealed that there was a reduction in the deposition of lipids in liver cells and aorta as compared to HFD group.The outcomes showed the defensive mechanism of Resveratrol against fructose-induced Metabolic Syndrome. The mechanism of protection may be due to an escalation of cellular antioxidants. The activity was found to increase in combination with amlodipine and pioglitazone.
Some Immunological and Histopathological Changes for Frequently Aborted Women with Toxoplasmosis Infection
Authors: Sukayna Jabbar Mushattat  , Malak Majid Almusawi  , Marwa Rahman Mohamed Al-Saedi
Published: November 2022

The investigation comprised physiological and histological exams of 70 women with Toxoplasmosis and 30 women who were not affected. Samples from 20 placentas were obtained from groups, as well as blood and physiological examinations. The findings of the current investigation displayed a fundamental increase in concentration of IP-10(133.5 ± 120) and MCP (220.9 ± 122) in blood serum of patients suffering from Toxoplasmosis infection and control group IP-10 (94.8 ± 82) and MCP (199.7 ± 76). There were histological changes in the placenta tissue in aborted women due to the rapid reproduction of the parasite, and large spaces in the tissue due to the parasite's formation of tissue bags, which resulted in the death of cells forming the placenta tissue due to the parasite's secretions and toxic substances. Abortion or congenital deformities in the pregnancy, as well as impairments to the newborn neurological system.
Study The Side Effects Of Administration Of A Traditional Product For Weight Gain In Albino Rats
Authors: Ashraf Rauf Muhammad Ali  , Ikhlass Ali AlHilaly  , Ola Riyad Abood  , Shaheen Jabbar  , Fatma Shakir  , Sajad Asaad
Published: November 2022

The modern studies on the treatment of excessive thinness have dedicated on the potential activity of plants to increases appetite. The aim of this study is to investigate the effect of Puma as a weight gain product and nutritional supplement on body metabolism on its administers and determine its safety. 9 male rats were weighted (130 to 190 g) and divided equally into 3 groups, the first group considered as control group and administered distilled water, the two other groups divided into a single dose group and a double dose group. Administered the prepared aqueous solution of puma fat face pills for 30 days. The animals weighed after 24 hr. of the last administration. The results showed after weeks of treatment that the animals didn't gain much weight compared to control group and there were no beneficial effects of this product. AST & ALT levels was high in the single and double dose group also there is a change in the levels of creatinin while the urea level didn’t change, the hisopathological study showed bleeding in kidneys and liver and more damage in these organs.
A CROSS SECTIONAL SURVEY TO KNOW THE PREVALENCE OF NOCTURNAL ENURESIS AND ASSOCIATED COMORBIDITIES IN CHILDREN AGED 5 TO 18 YEARS
Authors: Pradeep Swami  , Veenu Agarwal  , K C Aggarwal
Published: November 2022

Introduction: The present research was aimed to identify prevalence & associated comorbidities of nocturnal enuresis in children.Methods: Present study was a cross sectional survey, conducted in two government schools. The school, administration was briefed about this disease, its adverse impact on child’s school performance. Data collected was related to age, gender, some disease characteristics, and associated comorbidities. Questionnaire used had contact number of the hospital, some general instructions to help these children like restricted liquid intake in evening hours, regular frequent urination & maintenance of voiding diary. The permission to conduct the survey was granted by the schools. To maintain anonymity, to avoid embarrassment and to encourage maximum participation these were handed over to the class teachers who distributed these to the parents of all the students in next Parent teacher meeting. Children dropped these filled questionnaires in a box kept in common room.Results: Total 306 children were identified. Enuresis was commonest in age group 7-12 years. MNE was found in majority. Positive family history of enuresis & poor quality of sleep was present in 50.3% &32% children respectively. Functional constipation was found in 41.2% (126) & UTI in 8.8% (27) children. Only 18.9% (58) children were taken to a health care facility for NE. Parental punitive practices reported were humiliation and physical punishment in 83% &66.7% children.Conclusion: Nocturnal enuresis is a common under reported condition. Families and children are suffering instead of consulting a doctor parents’ resort to various punitive measures.
Distinctiveness of palatal rugae : A potential tool in sex identification
Authors: Shreya Singh  , L J Deepti  , Nancy Verma  , Madhav Nagpal  , Neeraj Grover  , Kanika Bhalla Prabhat
Published: November 2022

Background: Everyone has certain characteristics that set them apart from others. Variations in the palatal rugae pattern is one such feature which stay consistent throughout one's life specially edentulous patients. So, this rapidly emerging branch of forensic odontology can be taken as an adjuvant in investigation of criminals which has immense significance in giving more accuracy.Aim: The current study aims to compare distinctiveness of the palatal rugae in gender of various age and to investigate if the specific palatal rugae pattern may be utilised as a strategy for sex estimation.Methods: Model casts of 200 people were created, segregated & the prominent elevations on both the sides of median palatal raphae was analysed. The statistical analysis to compare the proportions was presented. Result: Wavy rugae patterns are more prevalent in males whereas curved rugae patterns in females.Conclusion: Association of palatal rugae behold the potential key in establishing the person’s sex which is crucially importance.
COMPARATIVE EVALUATION OF HARD AND SOFT TISSUE CHANGES AROUND IMMEDIATELY LOADED SHORT AND LONG DENTAL IMPLANTS: AN IN VIVO STUDY
Authors: Sonu kumar  , Rajiv Kumar Gupta  , Narendra Kumar  , Vikram Kapoor  , Pallavi Sirana  , Komal Kishlay
Published: November 2022

Background: Placing a dental implant in the resorbed alveolar ridge are always require complex implant surgeries. The hypothesis was that short implant could improve the implant success rate which is very conservative and efficient treatment modalities.Purpose: The purpose of the present study was to evaluate the hard and soft tissue changes around immediately loaded short and long dental implant.Material & Methods: A total of 15 patients were selected with 2 partially edentulous space and one short and one conventional implant was placed with immediate loading protocol. Then they were divided into two groups one immediately loaded short implant and second is immediately loaded long implants, hard and soft tissues changes were evaluated on day of implant placement and 1st month, 2nd months and 4th months.Results: The mean score value of marginal bone loss, plaque accumulation, probing depth and sulcular bleeding were seen to be more in long implant as compared to the short implant. The difference between them was deemed to be statistically insignificant (p<0.05)Conclusion: There was no significant difference recorded around immediately loaded short and conventional implant in survival rate. So, short implants could be used as an alternative for complex implant surgery in deficient ridges.
ETIOPATHOGENESIS OF XEROSTOMIA: A CONCISE REVIEW
Authors: Kanika Bhalla Prabhat  , Vandana Sharma  , L J Deepti
Published: November 2022

Xerostomia, or dryness in mouth is usually concerned with decrease in the amount of saliva flow causing severe discomfort to the patients. As saliva is the most beneficial fluid which play a very important role in the sensation of flavour perceived in the mouth and lubrication of tongue. Along with this it also contributes in defending of the oral mucous membranes by providing bactericidal action such as proteolytic enzymes, lysozyme, lacto-peroxidase and IgA, IgG antibodies.The significant risk factors for xerostomia may be systemic or be iatrogenic– demonstrated by many types of pharmacologically active agents or chemotherapy, ionized radiation which is used as adjuvant in destroying malignant cells and aging issues. The related syndrome to this group include Sjogren’s syndrome manifested primarily by lacrimal and salivary glands inflammation producing various clinical symptoms. This is a typical problem for diabetes patients which is correlated with inadequate salivary flow followed by alterations in the microcirculation. Several treatment strategies for the management of such condition include medications for lubrication of mucosa and saliva substitutes. But, understanding the primary cause of xerostomia enables quicker diagnosis and a most effective treatment strategy. The intent of this article is to briefly review the etiology of xerostomia along with risk factors.
Comparative evaluation of retention of lithium disilicate crowns with four different cementation systems- An in-vitro Study
Authors: Dhaniram Talukdar  , Bharti Dua  , Pankaj Datta  , Anupam Bhardwaj
Published: November 2022

AIM OF THE STUDY: This in vitro study was performed to compare the retention of pressable lithium disilicate crowns cemented with four different cementation systems.METHODS: Eighty single rooted maxillary 1st premolars were collected after excluding teeth with caries and/or previous restorations. Preparation of the samples was standardized by using a diamond bur mounted onto a surveyor. An anatomic crown was waxed on each tooth and then hot pressed using lithium disilicate ceramic (IPS e.max PRESS, IvoclarVivadent). The samples were randomly divided into 4 groups (n = 20) according to different cementation systems. Each group sample was subjected to a seating force of 50N using universal testing machine. Each upper block was pulled along the path of insertion of the crown with a crosshead speed of 1mm/min.RESULTS: Self adhesive resin cement showed the maximum tensile strength among all adhesive luting cements (2.65 MPa). Self etch resin cement group showed mean tensile strength of (1.78 MPa) that was marginally less than total etch resin cement (1.86 MPa). Glass ionomer cement exhibited least tensile strength (1.41 MPa) compared to the other three luting cements.CONCLUSION: Within the limitations of this in vitro study, it was concluded that lithium disilicate full coverage crowns cemented with self adhesive resin cement showed higher bond strength followed by total etch resin cement, self etch resin cement and glass ionomer cement.
A Narrative Review on Etiology and Mechanism of Aflatoxin B1 in the induction of Hepatocellular Carcinoma
Authors: Sivanesan Dhandayuthapani  , Anitha Chidamabaram  , Malarvili Thekkumalai  , Jyoti Batra
Published: November 2022

Hepatocellular carcinoma is one of the primary liver cancer. Even though the incidence of HCC differs among various geographic regions, ethnicity, gender and age, it is one of the most common malignancies among Asian and African populations. It is well represented as the fourth most common cancer in the world. It is estimated that more than 80% of HCC cases are attributed due to viruses including hepatitis B and C infections. However it is also quite interesting that consumption of hazardous alcohol, dietary exposure of aflatoxin1 and hemochromatosis are also highly associated with the initiation and development of HCC. Risk factors such as AFB1 could alter the DNA upon exposure, modify the proteins and induce oxidative stress and further leading to malignant transformation of the hepatocytes. In this review we narrated the basics of the etiology and molecular mechanisms behind the involvement of AFB1 in the initiation and development of hepatocellular carcinoma.
Journal of Pharmaceutical Negative Results ¦ Volume 13 ¦ Special Issue 6 ¦ 2022 1104 Affordability of orthodontic treatment: a step towards the economic evaluation
Authors: Mohit Chaturvedi  , Rajiv Ahluwalia  , Tina Chugh  , Dhruv Yadav  , Mayank Gupta  , Parvinder Kaur
Published: November 2022

Background: Improvements in dental health, function, beauty, and self-esteem are widely acknowledged advantages of orthodontic treatment. An economic evaluation of orthodontic treatment forms the basis for decision-making planning and management of dental care. Aim: This study aims to estimate the perception of patients seeking orthodontic treatment categorized according to age, education, and family income and to identify barriers that prevent them from considering treatment. Methodology: Proforma was sent to dental colleges and specific clinics from metro, urban and rural areas across India. 500 patients seeking orthodontic treatment took part in the survey. Data was collected and analyzed statistically. Results: Cost was the main factor, which patients felt was responsible for not completing treatment or preventing them to consider the treatment. All patients felt that a good smile should be included in the Right to Health by Government and steps should be taken to make this treatment accessible for all.
A Hybrid Genetic Particle Swarm Optimization Algorithm Based Fusion Protein Functionality Prediction
Authors: U. Subhashini  , P. Bhargavi  , S. Jyothi
Published: November 2022

A fusion protein is a protein with at least two domains that are each encoded by a different gene and are combined into a single polypeptide by transcription and translation. For example, chromosomal rearrangement could result in the in vivo production of fusion proteins. One such fusion protein is the one responsible for chronic myelogenous leukaemia, the BCR-ABL protein. Recombinant DNA techniques could be used to create fusion proteins in vitro. By combining genes or portion of genes from similar or dissimilar organisms, fusion genes and proteins may be produced. But, real-time lab experiments for automated fusion protein functionality prediction are expensive and time-consuming. This paper proposes a novel Fusion Protein Functionality Prediction based on a Hybrid Genetic Particle Swarm Optimization (HybGPSO) algorithm to deal with this problem. The cellular component, biological process, and molecular function of an unannotated fusion protein by the GO consortium are the three functionalities predicted by this algorithm. The results of the experiments demonstrate that the proposed HybGPSO algorithm accurately predicts the function of fusion proteins.
Hyperspectral Image Classification of Soils using Soft Computing Techniques
Authors: P. Bhargavi  , A. Rajitha  , S. Jyothi
Published: November 2022

In geotechnical engineering classification of soils is an important accept because to provide guidance about soils based on their experimental analysis. The classification of system can be done in various ways because one should not rely on empirical information for solving the problems. These soil types are classified based on their behavioural conditions and based on generalized information provided by the scientists, engineers and resource persons. Classification of soil type by visiting particular location is difficult so remote sensing images are used. The most widely used remote sensing method for classification of soils is hyperspectral image (HSI) technology. To classify HSI different soft computing techniques are applied and compared algorithms with their accuracies to know the best algorithm for classification of soil types.
Swachh Bharat Mission – An overview of its impact on knowledge and practices on sanitation, hygiene and waste disposal among general population in selected villages of Belagavi, Karnataka
Authors: Shivarajkumar Dandagi  , Naresh R. Godara
Published: November 2022

Introduction & Objectives: Sanitation and hygiene practices are inevitably an important component of everyone’s life. This is certainly a major public health concern in India and as a part of this, Swachh Bharat Mission (SBM), a national level cleanliness programme launched by Government of India in 2014 which has influenced the lifestyle and behaviour change among general population. The study aims to understand the impact of Swachh Bharat Mission (SBM) on knowledge and practices among general population.Methods: A descriptive study was carried out with a sample size of 300 in Kangrali Village for a period of 3 months. Convenient Sampling technique was used to get the desired sample size. A semi structured interview questionnaire was used to analyse the knowledge and practices. Descriptive and inferential statistics was calculated and SPSS 21.0 version software was used for analysis of data.Results: The study results revealed that 210 (70%) had access to household toilet, 114 (38%) still preferred open defecation, 272 (90.6%) cleaned house floor only with water. 231 (77%) had access to community bin. Interestingly, almost 298 (99.3%) people were aware about Swachh Bharat Mission. As far as knowledge was concerned, around 105 (35%) has good knowledge, 97 (32.3%) had average knowledge and 98 (32.6%) had poor knowledge regarding sanitation, hygiene, and waste disposal. On the other hand, majority 156 (52%) showed poor practices, 81 (27%) good practices and 63 (21%) with average practices related to sanitation, hygiene, and waste disposal. Age, gender, religion, type of family, occupation and socioeconomic status had significant association with knowledge.Conclusion: The results showed that though people had awareness regarding Swachh Bharat Mission, their practices were not healthy as far as the responses were recorded. In order to overcome this, proper educational model or awareness programme is required to educate the people and make them understand the importance of Swachh Bharat Mission which is one of the Government’s important and ambitious programme. The health of people is very important and to achieve optimal health, knowledge and practices related to hygiene and sanitation is of prime importance.
ENHANCING THE SOLUBILITY OF DIPYRIDAMOLE BY LIQUISOLID COMPACTS BASED ON A FACTORIAL DESIGN APPROACH
Authors: G.R.Prasanna Laxmi  , P.Shashikala
Published: November 2022

Dipyridamole is a phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. It is a poorly water-soluble drug with absolute bioavailability of 37-66 %. Water-insoluble drugs still have a poor dissolution rate, one of the biggest problems facing the pharmaceutical industry. To improve the dissolution rate of Dipyridamole, liquisolid compacts were developed in the present study. Liquidsolid formulations were prepared using Peceol, Avicel PH 112, and Aerosil, in different ratios, as a non-volatile solvent, carrier material and coating material respectively. Excipients and drug interactions were characterized through FT-IR. These studies showed no interaction between excipients and drug. 32 factorial design approach was implemented. The formulations were optimized using Design Expert version 13.00 (StatEase Inc., Minneapolis, MN, USA). An optimal formulation exhibited an angle of repose of 25.12°, a hardness of 3.1 kg/cm2 and a percentage cumulative drug release of 99.22 % after 10 minutes. The observed values were found to be similar to the predicted values. Based on these observations, DPY–O can be considered to be the optimum formulation.