bluuebunny/crossref_metadata_2025 huggingface dataset:
The Problem for a Mixed Equation with Fractional Power of the Bessel Operator
Authors: Дзарахохов А.В. , Шишкина Э.Л.
Published: April 2023

В последнее время особый интерес представляют уравнения с частными производными, содержащими дифференциальный оператор дробного порядка. Подобные уравнения и задачи для них находят применение в теории вязкой упругости, электрохимии, теории управления, моделировании эпидемий и пандемий и в других различных областях. Настоящая работа посвящена решению дифференциальных уравнений, содержащих оператор Бесселя дробной степени. В статье рассматривается прямое и обратное преобразование Мейера, модифицированное для удобства работы с оператором Бесселя дробной степени. Для рассматриваемого преобразования Мейера получена свертка. Используя преобразования Лапласа и Пуассона получены факторизации прямого и обратного преобразований Мейера. С использованием рассмотренного модифицированного преобразования Мейера находится решение обыкновенного дифференциального уравнения с оператором Бесселя дробной степени. Рассматривается нелокальная краевая задача для смешанного параболо-гиперболческого уравнения, содержащего дробной степени оператор Бесселя. Доказывается, что, при выполнении определенных условий гладкости входных функций задачи и выполнения условия сопряжения на линии раздела областей гиперболичности и параболичности, регулярное решение нелокальной краевой задачи для смешанного параболо-гиперболического уравнения с оператором Бесселя дробной степени существует и единственно.

Recently, of particular interest are partial differential equations containing a fractional order differential operator. Similar equations and problems for them find application in the theory of viscous elasticity, electrochemistry, control theory, modeling of epidemics and pandemics, and in various other areas. The present work is devoted to the solution of differential equations containing the Bessel operator of fractional degree. The article discusses the direct and inverse Meyer transforms, modified for the convenience of working with the Bessel operator of a fractional degree. For the considered Meyer transformation, a convolution is obtained. Using the Laplace and Poisson transformations, factorizations of the direct and inverse Meyer transformations are obtained. Using the considered modified Meyer transform, we find a solution to an ordinary differential equation with a Bessel operator of fractional degree. A nonlocal boundary value problem for a mixed parabolic-hyperbolic equation containing a fractional degree Bessel operator is considered. It is proved that, under certain conditions of smoothness of the input functions of the problem and the condition of conjugation on the dividing line of the regions of hyperbolicity and parabolicity, a regular solution of a nonlocal boundary value problem for a mixed parabolic-hyperbolic equation with a Bessel operator of fractional degree exists and is unique.
Neonatal Exposure to Titanium Dioxide Nanoparticles Modulates the Redox Balance in Infantile and Adult Female Rats
Authors:   Department of Medical Chemistry, Biochemistry and linical Biochemistry, Faculty of Medicine, Comenius University, Slovakia, M Dvorakova , S Scsukova ,   Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Slovakia, E Rollerova ,   Slovak Medical University, Faculty of Public Health, Department of Toxicology, Slovakia, AM Bujnakova ,   Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Slovakia, L Laubertova ,   Department of Medical Chemistry, Biochemistry and linical Biochemistry, Faculty of Medicine, Comenius University, Slovakia, K Konarikova ,   Department of Medical Chemistry, Biochemistry and linical Biochemistry, Faculty of Medicine, Comenius University, Slovakia, I Zitnanova ,   Department of Medical Chemistry, Biochemistry and linical Biochemistry, Faculty of Medicine, Comenius University, Slovakia
Published: April 2023

Objectives: The aim of our study was to determine a possible relationship between the redox state of the organism and the exposure to TiO2 Nanoparticles (NPs). Design and methods: TiO2 NPs (1% or 10% LD50 TiO2) were intraperitoneally administered to female Wistar rats from the Postnatal Day 4 (PND4) to PND7. Rats were sacrificed on the PND15 (infantile rats) or after the PND220 (adult rats). In plasma, Antioxidant Capacity (TEAC), concentration of protein carbonyls and lipoperoxides were measured. Hemolysates were used to determine the changes in catalase, Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) activities. Results: Young rats: 1% and 10% LD50 TiO2 induced the decrease in TEAC, lipoperoxide levels and Gluthione Peroxidase (GPx) activities and higher Superoxide Dismutase (SOD) activities in infantile rats, compared to controls. Adults: Significantly lower lipoperoxide levels, higher SOD and GPx activities were found in adults compared to young rats. 1% LD50 TiO2 significantly increased TEAC value and reduced SOD and GPX activities, but 10% LD50 TiO2 reduced TEAC compared to controls. Conclusion: Our results demonstrate that neonatal exposure to TiO2 NPs may modulate redox balance in female rats depending on the age, which might lead to alterations of their physiological functions.
Antityphoid Activity and Probable Mechanism of Action of 95% Ethanolic Extract of Enantia chlorantha Stem Bark
Authors:   Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon, MN Djimeli , SS Atsafack ,   Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon, JK Ndzotang ,   Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon, S Tankeo ,   Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon, GSS Njateng ,   Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon, J-M Mendimi Nkodo ,   Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon, D Gatsing ,   Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
Published: April 2023

Typhoid fevers are systemic diseases caused by Salmonella Typhi. These bacterial infections come from digestive route. The aim of this study was to evaluate the activity of the 95% ethanolic extract from Enantia chlorantha stem bark and to determine its mechanism of action. When performed, microdilution in liquid medium, was used for the evaluation of the in vitro antisalmonella activity on Salmonella Typhi ATCC 6539. The phytochemical screening was assessed by the standard methods. The mechanism of action of the extract was performed through biofilms and proton ATPases-H+ Pumps inhibition. In vitro antisalmonellal activity test reveals that the E. chlorantha extract presented MIC values of 128 μg/mL and MBC of 512 μg/mL on tested microorganism. The MBC/MIC ratio was equal to 4. Phytochemical analysis revealed the presence of alkaloids, anthocyanins, anthraquinons, flavonoids, phenols, and saponins in this extract. The later also inhibited biofilms formation and proton ATPases- H+ bacterial pumps. The present study demonstrates that ethanolic extract of Enantia chlorantha stem bark possesses an interesting antisalmonella activity and could then be used for the treatment of typhoid fever.
One Case of POMES Syndrome with “Limb Pain” As the Main Presentation
Authors:   Department of Neurology, Liaocheng People’s Hospital, Shandong Province, China, L Wang , Y Fan ,   Department of Neurology, Liaocheng People’s Hospital, Shandong Province, China, H Zhang ,   Department of Neurology, Liaocheng People’s Hospital, Shandong Province, China, X Dong ,   Department of Clinical Medicine, Qingdao University, Qingdao City, Shandong Province, 266000, Qingdao City, Shandong Province
Published: April 2023

Objective: To summarize the clinical manifestations, imaging features and gene mutation sites of a patient with pomes syndrome with “limb pain” as the main manifestation, so as to improve the understanding of this rare disease. Medical History: The patient was a 34 year old male with limb pain and fatigue for more than 20 days. Symptoms and Signs: The tongue is in the middle, the uvula is in the middle, the bilateral pharyngeal reflex disappears, the neck is soft, the muscle strength of both upper limbs is grade 5, the proximal muscle strength of both lower limbs is grade 4, and the distal muscle strength is grade 5. The muscle tension of the extremities is normal, the tendon reflex of the extremities disappears, and no obvious abnormalities are found in the examination of deep and shallow sensation and ataxia. The diagnostic method bone marrow puncture showed thrombocytosis. The pathological results showed that the hematopoietic cells of the three lines were proliferative, the oligoclonal bands in CSF were positive, and the oligoclonal bands in serum were positive. Serum immunofixation electrophoresis (March 30, 2018): IgG λ Abnormal monoclonal bands were found in the lane, and the type of monoclonal immunoglobulin was IgG- λ Type. Blood analysis suggested thrombocytosis (738 × 10°several L). There is no specific therapeutic drug, but hormone and hydroxyurea are effective. The clinical outcome was improved and the disease was gradually alleviated. The clinical conclusion is that poems syndrome is a rare clinical syndrome with various forms. Early intervention is effective for the prognosis of patients.
Angstrom-confined electrochemical synthesis of sub-unit cell non van der Waals 2D metal oxides
Authors: Ji Dali , Lee Yunah , Nishina Yuta , Kamiya Kazuhide , Daiyan Rahman , Wen Xinyue , Chu Dewei , Yoshimura Masamichi , Kumar Priyank , Andreeva Daria , Novoselov Kostya , Lee Gwan-Hyoung , Joshi Rakesh , Foller Tobias
Published: April 2023

Bottom-up electrochemical synthesis of atomically thin materials is desirable yet challenging, especially for non-van der Waals (vdW) materials. Thicknesses below few nm have not been reported yet, posing the question how thin can non-vdW materials be electrochemically synthesized? This is important as materials with (sub-) unit cell thickness often show remarkably different properties compared to their bulk form or thin films of several nm thickness. Here, we introduce a straightforward electrochemical method utilizing the angstrom-confinement of laminar reduced graphene oxide (rGO) nanochannels to obtain a centimeter-scale network of atomically thin (< 0.43nm) 2D-transition metal oxides (2D-TMO). The angstrom-confinement provides a thickness limitation, forcing sub-unit cell growth of 2D-TMO with oxygen and metal vacancies. We showcase that Cr2O3, a material without significant catalytic activity for OER in bulk form, can be activated as a high-performing catalyst if synthesized in the 2D sub-unit cell form. Our method displays the high activity of sub-unit cell form while retaining the stability of bulk form, promising to yield unexplored fundamental science and applications. We show that while retaining the advantages of bottom-up electrochemical synthesis like simplicity, high yield, and mild conditions, the thickness of TMO can be limited to sub-unit cell dimensions.
Flexible Topology: A new method for dynamic drug design
Authors: Donyapour Nazanin , Fathi Niazi Fatemeh , Roussey Nicole , Bose Samik , Dickson Alex
Published: April 2023

Ligand-induced conformational changes form the underpinnings of most essential biomolecular processes, however they are often neglected in screening and design applications, due to the high computational cost of simulating each candidate ligand individually. We propose a method called "Flexible Topology", where a ligand is comprised of a set of shapeshifting "ghost" atoms, whose atomic identities and connectivity can dynamically change over the course of a simulation. Ghost atoms are guided toward their target positions using a translation-, rotation-, and index-invariant restraint potential. When implemented with a large set possible targets, this can simulate trajectories in a coupled chemical-conformational space that allows solutions to molecular design problems to simply emerge over the course of a trajectory. It also provides a mechanism for observing ligand-induced conformational change, by allowing for the surrounding environment and the ghost atoms to respond to each other during the design process. This builds on a substantial history of alchemy in the field of molecular dynamics simulation, including the Lambda dynamics method developed by Brooks and coworkers [X. Kong and C.L. Brooks III, J. Chem. Phys. 105, 2414 (1996)], but takes it to an extreme by associating a set of four dynamical attributes with each shapeshifting atom that control not only its presence but its atomic identity. Here we outline the theoretical details of this method, its implementation using the OpenMM simulation package, and some preliminary studies of ghost particle assembly simulations in vaccum. We examine a set of 10 small molecules, ranging in size from 6 to 50 atoms, and show that Flexible Topology is able to consistently assemble all of these molecules to high accuracy, beginning from randomly initialized positions and attributes.
Teaching Old Presumptive Tests New Digital Tricks with Computer Vision for Forensic Applications
Authors: Bugeja Nathalie , Oliver Cameron , McGrath Nicole , McGuire Jake , Yan Chunhui , Carlysle-Davies Felicity , Reid Marc
Published: April 2023

Presumptive (or 'spot') tests have served forensic scientists, law enforcement, and legal practitioners for over a hundred years. Yet, the intended design of such tests, enabling quick identification of drugs by-eye, also hides their full potential. Here, we report the development and application of time-resolved imaging methods of reactions attending spot tests for amphetamines, barbiturates, and benzodiazepines. Analysis of the reaction videos helps distinguish drugs within the same structural class that, by-eye, are judged to give the same qualitative spot test result. It is envisaged that application of these results will bridge the existing suite of field and lab-based confirmatory forensic tests, and support a broader range of colorimetric sensing technologies.
Thermochromic behavior of polydiacetylene nanomaterials driven by charged peptide amphiphiles
Authors: Lim Sujeung , Cordova Dmitri Leo , Robang Alicia , Kuang Yuyao , Paravastu Anant , Arguilla Maxx , Ardoña Herdeline Ann
Published: April 2023

The stimuli-responsive chromogenic transitions in polydiacetylenes (PDA) result from the conformational changes that directly alter the electronic structure of the π-conjugated backbone. In this work, we studied the ability of electrostatic interactions to modulate the chromatic phases afforded by charged, amphiphilic peptide-PDA nanostructures and their coassembly under pH-neutral, aqueous environments. Two oppositely charged, diacetylene-bearing peptide sequences were used as model monomers in this study. Based on solid-state nuclear magnetic resonance (ssNMR) analyses, the positively charged, trilysine-containing sequence (K3GV) forms a β-sheet-like assembly with higher structural order than the disordered, negatively charged triaspartic acid-containing sequence (D3GV). The equimolar mixture of the two charged monomers results in a more ordered coassembly structure than D3GV, as evidenced by ssNMR, which still fulfills the geometric requirement to topochemically polymerize diacetylenes. At various temperatures tested, single component assemblies and coassembled peptide-PDAs all demonstrate a thermochromic response, with the hysteresis of the blue phase (planar conformation) spectral features being much larger than that of the red phase (twisted conformation). Resonance Raman spectroscopy of thin films revealed that the coexistence of blue and red phase chains is more stabilized in coassemblies that have electrostatic complementarity compared to their single component counterparts. Both the characterization of the solution and film samples at 20–80°C suggest that the red phase PDA with twisted conformation is more favored by the charge-coassembled material. In summary, this work shows the important role of the attractive electrostatic interactions arising from the peptidic side chains in controlling the adaptive properties of amphiphilic PDAs. Furthermore, this work sheds light on the nature of structural changes responsible for the thermally responsive chromatic transitions of a biomolecule-functionalized polymeric material and how this process can be directed by design-tunable electrostatic interactions.
Mannich base PIP-199 is a chemically unstable pan-assay interference compound
Authors: Wu Xinyi , Sudhakar Haritha , Alcock Lisa , Lau Yu Heng
Published: April 2023

PIP-199 is the only reported small molecule inhibitor of FANCM-RMI, a key protein-protein interaction that governs genome instability in the genetic disorders Fanconi Anemia and Bloom’s Syndrome. PIP-199 and close analogues that share the same indole-derived Mannich base core scaffold have been used as commercially available tool compounds for studying a wide range of therapeutically relevant biological pathways and targets, including the Alternative Lengthening of Telomeres (ALT), G-quadruplexes, pro-apoptotic proteins, and quorum sensing. Herein, we report the first published synthesis of PIP-199 and related analogues, demonstrating that the parent compound immediately decomposes in common aqueous buffers and some organic solvents. We characterize the breakdown products and show that PIP-199 and its more hydrolytically stable analogues show no observable activity in binding and competitive biophysical assays for FANCM-RMI. We conclude that PIP-199 is not an effective tool compound for biological studies, and that apparent activity in cellular studies likely arises from non-specific toxicity of mixed breakdown products. More generally, apparent inhibitors that share this indole-derived Mannich scaffold potentially represent a new family of pan-assay interference compounds (PAINS) that should be thoroughly assessed for aqueous stability prior to use in biological studies.
Benchmarking aspects of ab initio fragment models for accurate excimer potential energy surfaces
Authors: Barcza Bónis , Szirmai Ádám B. , Stanton John F. , Tajti Attila , Szalay Péter G.
Published: April 2023

While Coupled-Cluster methods have been proven to provide an accurate description of excited electronic states, the scaling of the computational costs with the system size limits the degree for which these methods can be applied. In this work different aspects of fragment-based approach are studied on non-covalently bound molecular complexes with interacting chromophores of the fragments (so called Frenkel pairs), such as pi-stacked nucleobases. The interaction of the fragments is considered at two distinct steps. First, the states localized on the fragments are described in the presence of the other fragment(s); for this we test two approaches. One method is founded on QM/MM principles, only including the electrostatic interaction between the fragments in the electronic structure calculation with Pauli repulsion and dispersion effects added separately. The other model, a Projection-based Embedding (PbE) using the Huzinaga equation includes both electrostatic and Pauli repulsion and only needs to be augmented by dispersion interactions. In both schemes the extended Effective Fragment Potential (EFP2) method of Gordon et al. was found to provide an adequate correction for the missing terms. In the second step, the interaction of the localized chromophores is modeled for a proper description of the excitonic coupling. Here the inclusion of purely electrostatic contributions appears to be sufficient: it is found that the Coulomb part of the coupling provides accurate splitting of the energies of interacting chromophores that are separated by more than 4 Angstrom.
Protein-like Colloidal Stability of MOF Nanoparticles Dictated by Solvent-Linker Interactions
Authors: LeRoy Michael , Mapile Ashley , Xiang Li , Khaliq Faiqa , Kadota Kentaro , Fabrizio Kevin , Zhang Xianghui , Ha Su , Wu Di , Yildirim Adem , Brozek Carl
Published: April 2023

Chemical separation membranes, drug delivery agents, and other applications of metal- organic frameworks (MOFs) benefit from preparing MOFs as nanoparticles (nanoMOFs) and by controlling the particle surface. Despite the lack of deliberately added surface ligands, common examples of nanoMOFs exhibit multi-week colloidal stability in a range of polar solvents, in stark contrast with most conventional nanoparticles requiring surface functionalization with bulky ligands, and yet the origin of this stability remains unknown. Here, we demonstrate that the “solubility” of nanoMOFs depends on the solubility of the constituent linkers and on the amount of exposed external surface area. Although the nanoMOF zeta potentials exceed |±20 mV|, these results indicate electrostatics alone cannot explain colloidal stability. Indeed, the identity of electrolyte ions at fixed ionic strengths induces divergent particle stabilities akin to the Hofmeister effect observed with proteins. Furthermore, nanoMOFs self-assemble into coronas with proteins to become stable under physiological conditions, even when similar surface charges between MOF and protein would be expected to repel. These results highlight the uniqueness of defining a MOF “surface” and suggest that nanoMOFs form a bridge between conventional nanoparticles and macromolecules, while opening fundamental questions into interfacial chemistry.
Structuring liquids through solvent-assisted interfacial association of oppositely charged polyelectrolytes and amphiphiles
Authors: Meszaros Robert , Bak Monika , Szalai Istvan , Varga Imre , Gyulai Gergo , Mihály Judith
Published: April 2023

Sculpting liquids into different shapes through arresting liquid/liquid (L/L) interfaces represents a hot area of nanoscience. Nanoparticle Surfactant (NPS) assemblies, based on confined interactions of functionalized nanoparticles or polymers with specific ligands at the L/L interface, offer a robust platform for synthesizing these structured liquids, which reveal exciting material properties due to the combination of the mobility of liquid components with the solid-like characteristic of NPS assemblies. There is an intense interest in novel structured liquids produced from simple compounds with versatile application potentials. Complexes of oppositely charged commercial polyelectrolytes and traditional aliphatic surfactants (AlS) are good candidates for this goal since they reveal rich structural features and could adsorb at various interfaces. However, they have not been applied yet for structuring liquids. In the present paper, we report on arrested fatty alcohol/water interfaces based on the association of a water-soluble polyelectrolyte (PE) and an oil-soluble fatty amine with the specific involvement of the organic solvent molecules, which act as cosurfactant in the surface region. The formed solid films enable the synthesis of temperature-sensitive all-in-liquid constructs from affordable materials and offer alternatives to bulk PE/AlS/alkanol assemblies prepared earlier through numerous synthesis steps.
Predicting Magnetic Coupling and Spin-Polarization Energy in Triangulene Analogues
Authors: Yu Hongde , Sun Jianwei , Heine Thomas
Published: April 2023

Triangulene and its analogue metal-free magnetic systems have garnered increasing attention since their discovery. Predicting the magnetic couplings and spin polarization energy with quantitative accuracy is beyond the predictive power of today’s density-functional theory (DFT) due to their intrinsic multi-reference character. Herein, we create a benchmark dataset of 25 magnetic systems with non-local spin densities, including the triangulene monomer, dimer, and their analogues. We calculate the magnetic coupling (J) and spin-polarization energy (ΔEspin) of these systems using complete active space self-consistent field (CASSCF) and coupled cluster methods as high-quality reference values. This reference data is then used to benchmark 22 DFT functionals commonly used in material science. Our results show that, while some functionals consistently correctly predict the qualitative character of the ground state, achieving quantitative accuracy with small relative errors is currently not feasible. PBE0, M06-2X, and MN15 are predicting the correct electronic ground state for all systems investigated here, and also have the lowest mean absolute error for predicting both ΔEspin (0.34 eV, 0.32 eV and 0.31 eV) and J (11.74 meV, 12.66 meV and 10.64 meV). They may therefore also serve as starting points for higher-level methods such as the GW or the random phase approximation. As other functionals fail for the prediction of the ground state, they cannot be recommended for metal-free magnetic systems.
Correlation evaluation of ion adsorption-based rare earth leaching performance based on zeta potential drop leaching
Authors: Li Xunhe , Li Yongxiu , Zhou Xuezhen , Zhou Huajiao , Wang Kang
Published: April 2023

Rare earth elements are indispensable raw materials for advanced aero-engines, special optical materials, and high-performance electronic products. With the development of social economy, the global demand for rare earth resources is increasing, and rare earths have become a key metal for the development of new industries and frontier technologies that are highly valued both at home and abroad. ion-adsorbed rare earth ores are an important source of rare earths, so the efficient green leaching of ion-adsorbed rare earths is important. Researchers found that the selection of efficient green leaching agent for ion-adsorbed rare earths is based on the zeta potential of tailing clay minerals in addition to leaching efficiency, and both zeta potential and leaching ion concentration are related to mineral acidity and alkalinity, and the pH of tailing water suspension is a direct indicator of environmental water quality requirements. Therefore, the efficiency of the leaching process is closely integrated with the environmental evaluation, and the characteristics and correlation of the changes in zeta potential, pH, conductivity and pollutant concentration of the pulp of clay mineral content during the leaching process of ore leaching and tailings aqueous electrolyte solution leaching are studied by evaluating the leaching system, and a set of correlation leaching efficiency and environmental impact evaluation method is established based on the results of the above analysis, which is of scientific development of ion adsorption rare earth resources It has important theoretical significance and practical application value.
cis-Selective Acyclic Diene Metathesis Polymerization of α, ω-Dienes
Authors: Kempel Samuel J. , Hsu Ting-Wei , Nicholson Jake L. , Michaudel Quentin
Published: April 2023

The cis/trans (Z/E) stereochemistry of repeating alkenes in polymers provides a powerful handle to modulate the thermal and mechanical properties of these soft materials, but synthetic methods to precisely dictate this parameter remain scarce. Herein, a cis-selective ADMET process of readily available α, ω-diene monomers with high functional-group tolerance is disclosed. Identification of a highly sterereoselective cyclometalated Ru catalyst allowed the synthesis of a broad array of polymers with cis-content up to 99%. This platform was leveraged to study the impact of the cis geometry on thermal and mechanical properties including through the synthesis of ABA triblock copolymers via extension of a cis-rich telechelic polyoctenamer with D,L-lactide. These results suggest that cis-selective ADMET affords an efficient strategy to tune the properties of a variety of polymers.
The linguistic and didactic potential of the ethnocultural concept of VYSHYVANKA in teaching Ukrainian as a foreign language
Authors: Prozhohina I.
Published: April 2023

Immersion of foreigners in the Ukrainian linguistic and cultural environment requires the teacher, as a facilitator of this process, to use effective methods and techniques of working with materials of linguistic and sociocultural content, the development of which is an urgent task of modern linguistic didactics. The author considers the linguistic and didactic potential of the Ukrainian cultural concept VYSHYVANKA in teaching Ukrainian as a foreign language in the framework of the contemporary educational and methodical paradigm, namely the competence-based approach to learning.

The powerful linguistic and didactic potential of the ethnocultural concept VYSHYVANKA can be used both in the practical course of Ukrainian as a foreign language and in teaching special educational disciplines, particularly with distinct linguocultural and/or scientific components, as well as in students’ research practice. This ethnocultural concept can be an object of research in course papers of philology students and their master theses. When studying a foreign language and culture it is appropriate to use comparative or cross-cultural analysis. This concept plays an important role in forming general communicative competence (in particular, its lexical and grammatical components), intercultural communicative, and linguistic and cultural competences.

The paper offers specific exercises and tasks for the development of the defined competencies in various types of speech activity: 1) for foreign undergraduate students of the philological specialties, students of preparatory departments, and for non-philologist foreigners of all levels of education (the focus is on lexemes with a national and cultural component: vyshyvanka, to embroider, embroidery, etc.); 2) for foreign masters and postgraduate students of philological and cultural specialties (the focus is on the ethnocultural concept VYSHYVANKA, its nominative field, and structure; the particular importance of the value dimension of the concept). The article contains some recommendations on the use of specific song material in classes on Ukrainian as a foreign language (“Two colours”, “Song about a towel”).
Destruction, Preservation, and Rethinking of Ukraine’s Urban Cultural Heritage during the Russo-Ukrainian War
Authors: Rachkov Yevhen
Published: April 2023

The article explores a range of problems relating to the destruction, preservation, and rethinking of Ukraine’s urban cultural heritage in the course of the ongoing Russian invasion. The author stresses that today protection of heritage remains an important aspect of Ukraine’s cultural policy. Since 2014, Russian military aggression has caused significant destruction in Ukrainian cities. The criminal actions of the Russian troops in Ukraine exhibit characteristics of urbicide, as they are aimed at destroying heterogeneous cultural and symbolic urban space and the diversity of the urban cultural heritage. According to experts, as a result of the Russo-Ukrainian War, the cultural heritage and cultural infrastructure of Ukraine will have suffered the heaviest destruction and damage since the Second World War. The article notes that under these conditions, new strategies for the protection of cultural heritage are being developed in Ukraine. Various public initiatives, the volunteer movement, and assistance from international organizations all play important roles. In general, Ukraine needs long-term support in the area of cultural heritage protection. Given the diversity and multifaceted nature of the country’s cultural heritage, we need to employ a variety of approaches and technologies to preserve it effectively. In particular, digital technologies, including the digitization of artifacts, should improve the record-keeping in this sphere and help keep track of the country’s cultural heritage. The author argues that the Russian aggression has led to a “turn” of sorts in the understanding of, and attitude towards, cultural heritage in Ukraine. The search for and revival of traditional components of national culture, as well as critical rethinking of the Russian imperial and Soviet heritage, are gaining more public prominence. In connection with this, the article touches on the new wave of toponymic changes in Ukrainian cities provoked by the full-scale Russian invasion, as well as on such developments as the dismantling of a certain category of urban monuments, reformatting of museum exhibits, etc.
Images of Ukrainian Cities in Wartime Narratives
Authors: Kurushyna Maryna
Published: April 2023

The study of wartime narratives throws light on the principal factors in the creation of images ofUkrainian cities. For the purposes of this work, a narrative is a story inboth verbal andvisual form. The analysis takes into account the time of appearance of an image and the specifics of its formation, construction, and functioning. The article examines the images of Ukrainian cities in Ukrainian narratives broadcast and available in the public space since the start of the full-scale Russian invasion. A threat to a city’s existence and the physical destruction of objects and landmarks, including symbolic ones, causes changes in the way of life and even its dismantling. This leads to the strengthening or weakening of some existing images, as well as to the emergence of new ones. The author particularly notes certain features of the images under study, such as the personification of cities, which are portrayed as combating the enemy, resisting, and revealing their character. A city’s image is assembled from a number of significant sites that are preserved and can be reproduced by individual and collective memory. Each city has a unique set of locations that are especially dear and important to the residents – sites that allow us to “read” the city as continuous history. The highest form of affinity with one’s city is a resident’s identification with it — symbolic inseparability, “growing into” each other. The heroic struggle of Ukrainian cities against the Russian aggressor would be impossible without preserving, first and foremost, their spiritual core, which is confirmed by the appearance of such epithets as “unbreakable” or “unconquered.” The borderland status of some of the studied cities is especially keenly felt. During the war, the frontier becomes not a melting pot of cultures, but a boundary between Us and Them. The wartime narratives emphasize the importance of borderland cities as outposts of Ukrainianness, fortress towns. Because of this, Ukrainianness becomes one of the dominant features of the images of Ukrainian cities, especially those close to the border. It becomes significant, vitally necessary. The preservation of this dominant factor in city images in wartime narratives (especially on the spiritual level) is an important marker of a city’s will to resist, its vital energy even in war.
Las aves focales del departamento del Huila
Authors: Brand-Prada Mijael , Betancourth-Toro Jhony Sebastián , Caviedes-Rubio Diego Iván , Sánchez-Peña Joaquín Fernando
Published: April 2023

Las aves, el grupo de vertebrados terrestres más diverso, se caracterizan por su amplia distribución geográfica y espacial en el mundo (Rangel-Salazar y Enríquez, 2015); esto les permite la onformación de relaciones con otros organismos, incluso la especie humana, haciéndolas parte del complejo ciclo de la vida (Banco de la República, 2016). Dicha interactividad puede ser entendida como servicios ecosistémicos que ayudan a la funcionalidad de las comunidades naturales (Thompson, 2006, como se citó en Jordano et al., 2009) y a la supervivencia y buen mantenimiento de los hábitats.
Pedagogías e Infancias: reflexiones desde el quehacer educativo
Authors: Meza Salcedo Guillermo , Torres Ramírez Carlos Mario , Arteaga Céspedes Paola Alejandra , Cruz Mendoza Narda Carime , Mesa Leidy Ximena , Garzón Borray Helen Alexandra , Vargas Orjuela Margy Paola , Patarroyo Herrera Lina María , Pino Perdomo Felipe Mauricio , Alarcón Cruz David Fernando
Published: April 2023

Este libro es resultado de varios estudios que asumieron como centro de análisis la cuestión de las infancias en relación con el gran campo de la educación. Su finalidad es ofrecer claves teóricas y metodológicas para repensar las ideas reificadas sobre las infancias, y consecuentemente, para resignificar el quehacer pedagógico desde nuevos elementos conceptuales acerca de éstas. Por ende, se recogen los análisis y reflexiones que, docentes de Licenciatura en Educación Infantil desde su labor académica y su experiencia profesional realizaron acerca de la formación en preescolar vista desde diversas perspectivas.
La socioafectividad y el vínculo afectivo: factores determinantes de la formación en la infancia
Authors: Patarroyo Herrera Lina Patricia
Published: April 2023

La infancia, como etapa del desarrollo primordial del ser humano, ha despertado especial interés desde la mirada de la psicología del desarrollo, puesto que los procesos que ocurren en esta edad son una base crucial de lo que se constituirá como la personalidad definida y estable del adulto. Aunado a este hecho, se destaca que, actualmente, el aumento de conductas delictivas en el país por parte de esta población se ha incrementado considerablemente; razón por la cual, desde las diversas instancias que lideran las políticas sobre infancia en Colombia, se ha visto la necesidad de estudiar este fenómeno desde diferentes dimensiones. Una de ellas es la indagación de la socioafectividad y el tipo de vínculo afectivo que pueden actuar como factores que predisponen o desencadenan esta conducta.
Pemberian Restitusi Sebagai Pelaksanaan Diversi Pada Perkara Pidana Anak
Authors: Amardhotillah Putri Tamara , Harefa Beniharmoni
Published: April 2023

  

This study aims to determine the implementation of restitution for diversion and the obstacles in seeking diversion at the three levels of the criminal justice process, investigation, prosecution, and examination in court. Restitution is a supporting factor in the success of the diversion process at different levels based on Government Regulation 43 of 2017 concerning the Implementation of Restitution for Children who are Victims of Criminal Acts. Children are supposed to be protected by the country, so this research is essential to ensure implementation of diversion should be prioritized in solving juvenile cases. This study used a normative juridical approach and had a novelty value because it examines the granting of restitution for diversion. From this research, restitution could be a way to get diversion and understand the obstacles in achieving it, such as economic constraints, unwilling parties to carry out diversion, and the limitations in several laws and regulations related to the implementation of diversion.

Penelitian ini bertujuan untuk mengetahui bagaimana pelaksanaan restitusi sebagai langkah pelaksanaan diversi pada perkara pidana anak sehingga dapat mengetahui bagaimana dan apa saja kendala dalam pengupayaan diversi di tiga tahap penyelesaian perkara pidana yakni pada tingkat penyidikan, penuntutan, dan pemeriksaan di pengadilan. Restitusi menjadi hal penunjang dalam keberhasilan proses diversi di berbagai tahapan, hal ini berdasarkan pada Peraturan Pemerintah Nomor 43 Tahun 2017 tentang Pelaksanaan Restitusi bagi Anak yang menjadi Korban Tindak Pidana. Penelitian ini penting dilakukan karena anak adalah orang yang dilindungi oleh negara dan agar pelaksanaan diversi menjadi hal yang diutamakan pada penyelesaian perkara anak. Penelitian ini menggunakan metode pendekatan yuridis normatif. Penelitian ini memiliki nilai kebaruan karena mengkaji pemberian restitusi dalam pelaksanaan diversi. Dari penelitian ini maka dapat diketahui bahwa restitusi dapat menjadi sarana dalam keberhasilan diversi dan untuk mengetahui kendala yang ditemukan dalam pelaksanaan diversi seperti kendala ekonomi, ketidakmauan para pihak untuk melaksanakan diversi, hingga kendala yang ada dalam peraturan perundang-undangan terkait pelaksanaan diversi.

  
Sürdürülebilir Ekonomik Kalkınma Çerçevesinde Yeşil Büyüme ve Yeşil Finans (Within The Frame of Sustainable Economic Development, Green Development and Green Finance)
Authors: Çanakçıoğlu Mustafa
Published: April 2023

Doğal kaynakların aşırı ve yanlış kullanımı, küresel düzeyde ciddi çevresel bozulmalara yol açmayı tetiklemiştir. Özellikle son on yılda orman yangınları, kasırga, sel gibi doğal afetler daha sık meydana geldi. Bu tür afetlerin azaltılması, uzun vadeli ve sürdürülebilir ekonomik kalkınmanın sağlanması için çevre dostu yatırımlara ihtiyaç duyulmaktadır. Çevreyi korumak, insanı ve refahını korumayı amaçladığından, insanlığın geleceği kapsamında çevreye duyarlı ve sağlıklı bir ekonomi için sürdürülebilir kalkınmanın uygulama adımlarının izlenmesi gerekmektedir. Bu süreci gerçekleştirmek, daha verimli kaynak kullanımını destekleyerek çevreyi iyileştirmek ve ekolojik dengenin korunması, enerji tasarrufu, daha temiz enerjiler, yeşil binalar gibi daha yeşil yatırımları desteklemek için yeşil finans kavramı ortaya atılmıştır. Böylece, yeşil finans hem daha yeşil kalkınmaya hem de ekonomik ve sürdürülebilir kalkınma hedeflerine hizmet edebilir. Bu bağlamda, mevcut çalışmanın temel amacı, araştırma topluluğundaki araştırmacı ve yazarlara katkıda bulunmak bir yana, yeşil kalkınma ve yeşil finans ile ilgili merkezi kavramı tanımlamak ve bu kavramlar ile sürdürülebilirlik arasındaki ilişkileri ortaya koymaktır. Çalışmanın bir diğer amacı da daha yeşil kalkınmaya yönelik yatırımları gerçekleştirmek için günümüz dünyasında yaygın olarak kullanılan yeşil finans araçlarını ortaya koymaktır.
Indian Act Philanthropy: Why are Community Foundations Missing from Native Communities in Manitoba, Canada?
Authors: Blacksmith Craig , Thapa Keshab , Stormhunter Tayzia
Published: April 2023

Could a philanthropic model aimed at community development enforce colonial policy rather than providing equitable economic opportunity? This research analyzes the transcripts of 20 public webinars on philanthropy and the Indian Act and maps the 54 community foundations in Manitoba, Canada. All 54 community foundations in Manitoba service only settler-dominated cities and municipalities, with none on Native communities. As community foundations serve only their specific geographical areas, the community foundations in Manitoba effectively concentrate wealth in settler-dominated cities and municipalities, taking away needed resources from Native communities. In excluding the poorest communities in Manitoba, this philanthropic model further entrenches marginalization, poverty, and health risks for Native people on Native communities.
TÓPICOS RELACIONADOS À AVALIAÇÃO DE CARCAÇA E CARNE CONFINAMENTO
Authors: Dib Renato Tângari
Published: April 2023

O livro aborda que o Brasil detém o maior rebanho bovino comercial do mun- do, composto por animais que possuem em sua composição genéti- ca alta proporção de raça de origem zebuína. Numericamente pode- -se ressaltar o alto potencial de atender o mercado nacional e inter- nacional em quantidade e qualidade de carne bovina (Jorge Júnior et al. 2006).
No cenário mundial o Brasil é um importante produtor e ex- portador de carne bovina em um mercado altamente exigente, prin- cipalmente nas questões qualitativas. A participação efetiva dos pro- dutores que necessitam ter consciência da melhoria genética, melho- res práticas de manejo, alimentação e nutrição do rebanho é essen- cial neste contexto (Façanha et al., 2014).
Caso 1
Authors: Moura Ana Paula Carvalhal , Neme Glaucy Lane , Mattos Leandro Accardo de
Published: April 2023

• 33 anos, dismenorreia desde a menarca e cólica intestinal intensa cíclica, com piora progressiva - EVA 10 (escala visual analógica da dor, que varia de 0 a 10). Utilizou anticoncepcional oral por vários anos, Allurene® e MIRENA®, sem melhora significativa.
• Nuligesta, sem desejo reprodutivo atual.
• Toque: espessamento do fundo de saco posterior.
• AP – ndn, sem cirurgias anteriores.
• Exames disponíveis:
– CA 125: 30 U/ml;
– USTV de rotina: útero, endométrio e ovário direito normais. Cisto espesso no ovário esquerdo de 3,0 cm.
Study the Effect of Low Level Laser (LLL) on the Histological Changes of Lymph Node Tissue in Mice Inoculated with Mammary Gland Carcinoma
Authors: Khalee Aida Z. , Ahmed Anwar Albir
Published: April 2023

This study was conducted on normal mice. The mice were divided into three groups of five mice each (A,B and C ) and two control groups of three mice each. The second control group and the three other groups (A,B and C) of mice were inoculated with mammary gland carcinoma. After (11) days of successful tumour growth, the tumours appeared in different parts of the animal bodies in accordance with the gross observations. All the animal groups (A,B and C) under study were irradiated with laser in different duration times (1-3) weeks consecutively. According to the histological sections of the lymph nodes of the animals of the groups (A,B and C) the results showed various histological changes in the lymphocytes such as increased size and multiplication of the nuclei, cytoplasm cleavage in group (B) animals in comparison with the histological changes which were more abundant in the lymphocytes of the lymph nodes of group (C) animals that irradiated with laser of duration time of three weeks, whereas the histological changes that occurred in the lymphocytes of the lymph nodes of both group (A) animals which irradiated with laser of duration time of one week and the second control group of animals which inoculated with mammary gland carcinoma (non-irradiated with laser) were multiplication of the nuclei in some lymphocytes of the lymph nodes. The aim of this study was to evaluate the effect of low level laser (LLL) on the histological changes by stimulating the lymph node action in order to inhabit cancer cells activity
Newcastle Disease Virus Iraqi Oncolytic Strain Induce Apoptosis in Tumor Cells Through Endoplasmic Reticulum Pathway
Authors: Al-Shammari Ahmed M.
Published: April 2023

I n tumor pathogenesis and metastasis, defects in apoptosis are essential. They allow tumor cells to overcome nutrient deprivation, absence of growth-stimulating signals and presence of growth-inhibitory signals. Newcastle disease virus Iraqi Strain is interesting oncolytic agent with promising anti-tumor properties. One of the major anti-tumor properties is apoptotic induction. This experiment aimed to investigate the ability of Iraqi strain of NDV to induce apoptosis in vitro and in vivo and to give preliminary look about the main pathway that induces apoptosis. Mitochondrial permeability transition apoptosis test was used for detecting apoptosis in vitro and mAb Rabbit anti-mouse caspase-12 was used for tumor sections for in vivo experiment. In vitro results revealed that NDV infection induce apoptosis significantly when compared to control cells. In vivo Immunohistochemical Detection of Caspase-12 in Mammary Adenocarcinoma revealed a significantly (p<0.05) marked increase in the mean percentage of cells expressing caspase-12 in NDV treated group compared with the untreated control group at day 7, 14 and at day 31. These results revealed that NDV had powerful effect on inducing apoptosis in AMN3 mammary adenocarcinoma in vitro. Moreover, caspase-12 expression was high in tumor sections which suggest that NDV induce endoplasmic reticulum apoptosis pathway. This study indicating the role of NDV Iraqi strain in inducing apoptosis through ER pathway in cancer cell which is interesting feature that may make NDV Iraqi strain is a good addition to antitumor arsenal.