bluuebunny/crossref_metadata_2025 huggingface dataset:
Manifestations of Ocular Fundus in Children with Febrile Seizures
Authors: Guo Hui , Lan Yuqing , Wang Mei , Xiao Jianhui , Hu Yuxin , Xia Zhaoxia
Published: August 2010

Purpose:

To study the potential incidence of retinopathy in children with febrile seizures.

Methods:

Thirty-four children with febrile seizures, aged 3 months to 9 years and admitted from January 2000 to June 2008, were retrospectively analyzed. All cases received fundus examination within 24 hours after admission and the incidence of retinopathy was calculated.

Results:

None of the subjects was found to have retinal hemorrhages. Therefore, using Hanley’s Rule of Three, the upper limit of 95% confidence interval of retinal hemorrhages following febrile seizures in children is less than 10%.

Conclusion:

The incidence of retinal hemorrhages in children with febrile seizures is lower than 10%. If retinal hemorrhages are found in children with febrile seizures, other causes need to be considered.
Outcome Study of Graded Unilateral Medial Rectus Recession for Small to Moderate Angle Esotropia
Authors: Wang Lihua , Nelson Leonard B.
Published: August 2010

Purpose:
To report an outcome study of 123 consecutive patients treated by graded unilateral medial rectus recession for small to moderate angle esotropia over an 8-year period with a minimum follow-up of 6 months.

Methods:
The records of patients who underwent unilateral medial rectus recession for constant esotropia measuring 15 to 35 prism diopters (PD) were reviewed. Unilateral medial rectus recession of 5.0, 5.5, 6.0, 6.5, and 7.0 mm was performed for 15 to 18, 19 to 20, 21 to 25, 26 to 30, and 31 to 35 PD of esodeviation, respectively. Postoperative follow-up was at least 6 months. Successful alignment was defined as ±5 PD of orthophoria in primary and lateral gaze while viewing distant and near accommodative targets.

Results:
The eyes of 96.8% of the patients were successfully aligned and the average deviation corrected was 17.33 ± 1.16 PD for 5 mm, 18.57 ± 2.51 PD for 5.5 mm, 23.67 ± 4.91 PD for 6 mm, 26.68 ± 3.87 PD for 6.5 mm, and 31.93 ± 3.26 PD for 7 mm unilateral medial rectus recession at 6-month follow-up. Seventy-four patients (83.2%) with more than 6 months of follow-up achieved successful alignment, 14 (15.7%) were under-corrected, and 1 (1.1%) was overcorrected.

Conclusion:
Successful alignment was achieved in most esotropic patients treated by the graded unilateral medial rectus recessions. The surgical guidelines provide a reference for the treatment of small to moderate angle esotropia.
Congenital Cystic Eye: A Clinicopathologic Study
Authors: Mehta Mridula , Pushker Neelam , Sen Seema , Sharma Sanjay , Gupta Kamlesh , Bajaj Mandeep S. , Ghose Supriyo
Published: August 2010

Congenital cystic eye is an extremely rare congenital ocular anomaly where a cystic mass or neuroglial tissue replaces normal eyeball secondary to failure of invagination of the optic vesicle. The authors describe a case of a 13-year-old girl, including clinical, imaging, intraoperative, and histopathological findings of this uncommon malformation. In addition, it was associated with ectopic glial tissue in the brain, which is also a rare association of this anomaly.
A Surgical Option for Antipodean Strabismus: Four Horizontal Muscle Resection
Authors: Mellington Faye E. , Assaf Ahmed A.
Published: August 2010

The authors report a case of symptomatic antipodean strabismus caused by a combination of mechanical restriction of eye movement secondary to thyroid eye disease, longstanding intermittent divergence, and convergence weakness, which was alleviated by simultaneous resection of all four horizontal recti muscles.
Implications of an Aging Population for Mental Health Nurses
Authors: Loge Julianne
Published: August 2010

The rapidly increasing numbers of older adults with dementia and other mental health problems throughout the world have huge ramifications for nurses who will care for these individuals, as well as for health care systems. This article explores some current problems in the health care systems and makes suggestions for better, more efficient ways to meet the growing mental health needs of the aging population. It also addresses moral-ethical dilemmas that will likely affect mental health nurses caring for this population.
Treatment Settings and Metabolic Monitoring for People Experiencing First-Episode Psychosis
Authors: Batscha Catherine , Schneiderhan Mark E. , Kataria Yachana , Rosen Cherise , Marvin Robert W.
Published: August 2010

Monitoring for metabolic sequelae of antipsychotic medications is inconsistent in clinical settings. In this study, frequency of such monitoring in 40 individuals experiencing a first episode of psychosis was analyzed according to the setting in which they received treatment (i.e., inpatient unit, outpatient clinic, or metabolic screening clinic). The traditional outpatient clinic was the least likely of the three settings to monitor blood glucose, blood pressure, weight, and waist circumference. In any setting, blood lipids were measured in only 2 of the 40 patients. Reasons for these findings and recommendations for reducing barriers to screening are presented.
Mental Health Parity Legislation
Authors: Smaldone Arlene , Cullen-Drill Mary
Published: August 2010

Although recognition and treatment of mental health disorders have become integrated into routine medical care, inequities remain regarding limits on mental health outpatient visits and higher copayments and deductibles required for mental health services when accessed. Two federal laws were passed by Congress in 2008: The Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act and the Medicare Improvements for Patients and Providers Act. Both laws became effective on January 1, 2010. The purpose of this article is to discuss provisions of each act and provide clinical examples describing how patients are affected by lack of parity and may potentially benefit from implementation of these new laws. Using available evidence, we examine the potential strengths and limitations of mental health parity legislation from the health policy perspectives of health care access, cost, and quality and identify the important role of nurses as patient and mental health parity advocates.
Vaccine Cold Chain: Part 2. Training Personnel and Program Management
Authors: Rogers Bonnie , Dennison Kim , Adepoju Nikki , Dowd Shelia , Uedoi Kenneth
Published: August 2010

The Centers for Disease Control and Prevention reports that professionals in clinic settings may not be adequately storing and handling vaccine, leading to insufficient immunity of vaccinated individuals. Part 2 of this article provides information about the importance of adequate personnel training and program management policies and procedures needed to implement and maintain an effective vaccine cold chain program.
Spontaneous Improvement of Channel Deposits Following Intacs Implantation
Authors: Kaufman Matthew B. , Dhaliwal Deepinder K.
Published: August 2010

Purpose:

To report a case of filamentous crystalline channel deposits and stromal haze extending outside the channel, which continued to worsen more than 3 years after implantation before eventually improving without significant intervention.

Methods:

A 48-year-old woman presented for refractive surgery evaluation. Uncorrected visual acuity was 20/400 in both eyes. Ocular history was significant for mild blepharitis but was otherwise normal. Approximately 4 months after bilateral Intacs (KeraVision) implantation, the patient developed intrachannel deposits in both eyes, which had increased significantly at 3-year follow-up.

Results:

The intrachannel deposits and haze spontaneously improved, and 9 years following implantation few deposits and little haze remained.

Conclusions:

Channel deposits, opacification, and haze are widely reported complications following the implantation of intrastromal corneal ring segments. Such deposits and opacifications are generally not clinically significant and may resolve spontaneously.
Late Onset Secondary Cataract Following Implantation of an Iris-Fixated Phakic Intraocular Lens
Authors: Liu Anthony , Manche Edward E.
Published: August 2010

Purpose:

To report a case of bilateral late onset anterior cortical cataract following implantation of an iris-fixated phakic intraocular lens (pIOL).

Methods:

Single observational case report.

Results:

Three and a half years following uncomplicated consecutive implantation of iris-fixated pIOL in both eyes, anterior cortical cataract changes inferiorly emanating from the site of enclavation of the lens in the right eye were noted. By 7 years after implantation, anterior cortical cataract changes were seen emanating from the enclavation sites superiorly and inferiorly in both eyes. These cataracts did not cause any loss of corrected distance visual acuity.

Conclusions:

This case demonstrates that a potential complication of an iris-fixated pIOL is late onset secondary cataract formation.
Participation Patterns in Preschool Children with an Autism Spectrum Disorder
Authors: LaVesser Patti , Berg Christine
Published: August 2010

An understanding of participation patterns in preschool-aged children with an autism spectrum disorder will allow the occupation therapy practitioner to focus on goals relevant to the child and family. This study compares participation patterns and barriers to participation in children with an autism spectrum disorder with those of children with no diagnosis. Using the Preschool Activity Card Sort, parent interviews revealed children with an autism diagnosis participate in fewer preschool activities of self-care, community mobility, vigorous leisure, sedentary leisure, social interaction, chores, and education than children with no diagnosis. Reasons for non-participation generally focused on child behaviors; parents gave opportunities to participate, but the child, for a variety of reasons, could not capitalize on the opportunity. Practitioners can assist the family in managing the child's responses and behavior in a wide range of preschool activities.
Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in Macrophages
Authors: Hamilton Outtz Hasina , Wu June K. , Wang Xing , Kitajewski Jan
Published: August 2010

We investigated whether Notch signaling plays a role in regulating macrophage responses to inflammation. In a wound healing assay, macrophage recruitment was decreased in Notch1+/− mice, and the wounds were characterized by decreased TNF-α expression. As wound healing progressed, Notch1+/− wounds had increased vascularization and collagen deposition compared with wild-type wounds. In mice with myeloid-specific Notch1 deletion, wounds had decreased macrophage recruitment as well as decreased TNF-α expression, indicating the specific role of Notch1 in the inflammatory response in these cells. In vitro, we found that vascular endothelial growth factor receptor-1 (VEGFR-1) was upregulated in macrophages in response to LPS/IFN-γ and that this upregulation depended on Notch signaling. Furthermore, macrophages from Notch1+/− mice had decreased expression of VEGFR-1 compared with macrophages from wild-type mice, whereas VEGFR-1 expression in Notch4−/− macrophages was normal. Inhibition of Notch signaling decreased induction of the inflammatory cytokines IL-6, IL-12, CXCL10, MCP-1, monokine induced by IFN-γ, and TNF-α in macrophages in response to LPS/IFN-γ. Additionally, macrophages from Notch1+/− mice demonstrated decreased induction of IL-6, IL-12, and TNF-α in response to stimulation compared with wild-type mice. Thus, both pharmacological inhibition of Notch and genetic analysis demonstrate that Notch1 regulates VEGFR-1 and cytokine expression in macrophages. We have also established that Notch1 is important for the inflammatory response during wound healing in mice.
A Bilinear Fractional Integral on Compact Lie Groups
Authors: Chen Jiecheng , Fan Dashan
Published: August 2010

As an analog of a well-known theoremon the bilinear fractional integral on ℝn by Kenig and Stein, we establish the similar boundedness property for a bilinear fractional integral on a compact Lie group. Our result is also a generalization of our recent theorem about the bilinear fractional integral on torus.
Star-Shapedness and K-Orbits in Complex Semisimple Lie Algebras
Authors: Cheung Wai-Shun , Tam Tin-Yau
Published: August 2010

Given a complex semisimple Lie algebra is a compact real form of g), let be the orthogonal projection (with respect to the Killing form) onto the Cartan subalgebra , where t is a maximal abelian subalgebra of . Given x ∈ g, we consider π(Ad(K)x), where K is the analytic subgroup G corresponding to , and show that it is star-shaped. The result extends a result of Tsing. We also consider the generalized numerical range f (Ad(K)x), where f is a linear functional on g. We establish the star-shapedness of f (Ad(K)x) for simple Lie algebras of type B.
Sequential Order under PFA
Authors: Dow Alan
Published: August 2010

It is shown that it follows from PFA that there is no compact scattered space of height greater than ω in which the sequential order and the scattering heights coincide.
Manifold-Valued Holomorphic Approximation
Authors: Stout Edgar Lee
Published: August 2010

This note considers the problem of approximating continuous maps from sets in complex spaces into complex manifolds by holomorphic maps.
Modelling deep convection and its impacts on the tropical tropopause layer
Authors: Hosking J. S. , Russo M. R. , Braesicke P. , Pyle J. A.
Published: August 2010

Abstract. The UK Met Office's Unified Model is used at a high global resolution (N216, ~0.83° × ~0.56°, ~60 km) to assess the impact of deep tropical convection on the structure of the tropical tropopause layer (TTL). We focus on the potential for rapid transport of short-lived ozone depleting species to the stratosphere by rapid convective uplift. The modelled horizontal structure of organised convection is shown to match closely with signatures found in the OLR satellite data. In the model, deep convective elevators rapidly lift air from 4–5 km up to 12–14 km. The influx of tropospheric air entering the TTL (11–12 km) is similar for all tropical regions with most convection stopping below ~14 km. The tropical tropopause is coldest and driest between November and February, coinciding with the greatest upwelling over the tropical warm pool. As this deep convection is co-located with bromine-rich biogenic coastal emissions, this period and location could potentially be the preferential gateway for stratospheric bromine.
Retrieval of macrophysical cloud parameters from MIPAS: algorithm description and preliminary validation
Authors: Hurley J. , Dudhia A. , Grainger R. G.
Published: August 2010

Abstract. The Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) onboard ENVISAT has the potential to be particularly useful for studying high, thin clouds, which have been difficult to observe in the past. This paper details the development, implementation and testing of an optimal-estimation-type retrieval for three macrophysical cloud parameters (cloud top height, cloud top temperature and cloud extinction coefficient) from infrared spectra measured by MIPAS, employing additional information derived to improve the choice of a priori. The retrieval is applied and initially validated on MIPAS data. From application to MIPAS data, the retrieved cloud top heights are assessed to be accurate to within 50 m, the cloud top temperatures to within 0.5 K and extinction coefficients to within a factor of 15%. This algorithm has been adopted by the European Space Agency's ''MIPclouds'' project, which itself recognises the potential of MIPAS beyond monitoring atmospheric chemistry and seeks to study clouds themselves rigorously using MIPAS.
Design and Characterization of Novel Wear Resistant Multilayer CVD Coatings with Improved Adhesion Between Al2O3 and Ti(C,N)
Authors: Garcia José , Pitonak Reinhard , Weißenbacher Ronald , Köpf Arno , Soldera Flavio , Suarez Sebastián , Miguel Federico , Pinto Haroldo , Kostka Aleksander , Mücklich Frank
Published: August 2010

Multilayer CVD coatings for high speed cutting applications were designed to achieve high wear and heat resistance during machining of steel alloys. In this work the microstructure and cutting performance of these novel multilayer CVD coatings are investigated and compared with standard CVD multilayer coatings. 3D‐FIB tomography is used to characterize the microstructure of the layers, especially the transition between the Ti(C,N) and the Al2O3 layer. The 3D reconstruction of the surface of the Ti(C,N) layer shows the formation of protruded Ti(C,N) grains with a very particular architecture, which penetrate into the Al2O3 top‐layer, providing a mechanical anchoring between both layers. Cemented carbides coated with the novel CVD multilayer present reduced crater and flank wear as well as improved adherence between the Al2O3 top‐layer and the Ti(C,N) layer leading to a dramatic improvement of cutting performance.
Beyond Intercalation‐Based Li‐Ion Batteries: The State of the Art and Challenges of Electrode Materials Reacting Through Conversion Reactions
Authors: Cabana Jordi , Monconduit Laure , Larcher Dominique , Palacín M. Rosa
Published: August 2010

Despite the imminent commercial introduction of Li‐ion batteries in electric drive vehicles and their proposed use as enablers of smart grids based on renewable energy technologies, an intensive quest for new electrode materials that bring about improvements in energy density, cycle life, cost, and safety is still underway. This Progress Report highlights the recent developments and the future prospects of the use of phases that react through conversion reactions as both positive and negative electrode materials in Li‐ion batteries. By moving beyond classical intercalation reactions, a variety of low cost compounds with gravimetric specific capacities that are two‐to‐five times larger than those attained with currently used materials, such as graphite and LiCoO2, can be achieved. Nonetheless, several factors currently handicap the applicability of electrode materials entailing conversion reactions. These factors, together with the scientific breakthroughs that are necessary to fully assess the practicality of this concept, are reviewed in this report.
Local Electrochemical Functionality in Energy Storage Materials and Devices by Scanning Probe Microscopies: Status and Perspectives
Authors: Kalinin Sergei V. , Balke Nina
Published: August 2010

Energy storage and conversion systems are an integral component of emerging green technologies, including mobile electronic devices, automotive, and storage components of solar and wind energy economics. Despite the rapidly expanding manufacturing capabilities and wealth of phenomenological information on the macroscopic device behaviors, the microscopic mechanisms underpinning battery and fuel cell operations in the nanometer–micrometer range are virtually unknown. This lack of information is due to the dearth of experimental techniques capable of addressing elementary mechanisms involved in battery operation, including electronic and ion transport, vacancy injection, and interfacial reactions, on the nanometer scale. In this article, a brief overview of scanning probe microscopy (SPM) methods addressing nanoscale electrochemical functionalities is provided and compared with macroscopic electrochemical methods. Future applications of emergent SPM methods, including near field optical, electromechanical, microwave, and thermal probes and combined SPM‐(S)TEM (scanning transmission electron microscopy) methods in energy storage and conversion materials are discussed.
One‐Step Synthesis of Chiral Azamacrocycles via Palladium‐Catalyzed Enantioselective Amination of 1,5‐Dichloroanthraquinone and 1,5‐Dichloroanthracene
Authors: Ranyuk Elena R. , Averin Alexei D. , Beletskaya Irina P.
Published: August 2010

Asymmetric amination of 1,5‐dichloroanthraquinone and 1,5‐dichloroanthracene with di‐ and trioxadiamines catalyzed by palladium complexes with various chiral phosphine ligands gave chiral macrocycles with ee values of up to 60%. The dependence of the chemical yields and enantiomeric excess on the nature of the starting compounds and the phosphine ligands employed was demonstrated. An unexpected spontaneous resolution upon crystallization of the macrocycle comprising anthraquinone and dioxadiamine moieties was observed while in the case of the macrocycle with a trioxadiamine linker racemic monocrystals were obtained. Crystallization of the enantiomerically enriched mixtures afforded chiral macrocycles with 88–99% ee.
Practical Iron‐Catalyzed Allylations of Aryl Grignard Reagents
Authors: Mayer Matthias , Czaplik Waldemar M. , Jacobi von Wangelin Axel
Published: August 2010

An operationally simple iron‐catalyzed reductive cross‐coupling reaction between aryl halides and allyl electrophiles has been developed. The underlying domino process exhibits high versatility with respect to the allylic leaving group (acetate, tosylate, diethyl phosphate, methyl carbonate, trimethylsilanolate, methanethiolate, chloride, bromide) and high economic and environmental sustainability with respect to the catalyst system (0.2–5 mol% tris(acetylacetonato)iron(III), ligand‐free) and reaction conditions (tetrahydrofuran, 0 °C, 45 min).
Sulfur‐Assisted and 1,8‐Diazabicyclo[5.4.0]undec‐7‐ene (DBU)‐Catalyzed Cyclization of 2‐Alkynylanilines for the Metal‐Free Synthesis of Indole Derivatives
Authors: Zhou Hongwei , Zhu Da , Xing Yanpeng , Huang Huafeng
Published: August 2010

A sulfur‐assisted and 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU)‐catalyzed cyclization of 2‐alkynylanilines for the metal‐free synthesis of indole derivatives is reported. As a result of the metal‐free process, the ready availability of the starting materials and the simple and convenient operation, the type of reaction presented here has potential utility in organic synthesis. A 10‐gram scale preparation may demonstrate the possibility of its application in the environmentally friendly synthesis of indole derivatives.
Enantioselective Alcoholysis of meso‐Glutaric Anhydrides Catalyzed by Cinchona‐Based Sulfonamide Catalysts
Authors: Park Sang Eun , Nam Eun Hye , Jang Hyeong Bin , Oh Joong Suk , Some Surajit , Lee Yong Seop , Song Choong Eui
Published: August 2010

The bifunctional Cinchona‐based sulfonamide catalysts showed the highest levels of enantioselectivity reported to date in the alcoholytic desymmetrization of meso‐glutaric anhydrides. Density functional theory (DFT) computational studies provide detailed insight into the observed sense of enantioselectivity. Moreover, detailed experimental studies and single crystal X‐ray analysis confirmed that these bifunctional organocatalysts 3 do not form H‐bonded self‐aggregates in both solution and solid state. The synthetic utility of this methodology was also demonstrated in the synthesis of pharmaceutically important γ‐amino acids, such as (S)‐pregabalin. Of the many asymmetric syntheses of enantiomerically pure (S)‐pregabalin reported to date, our synthesis requires the least number of and the simplest steps.
Three‐dimensional ground‐penetrating radar strategies over an indoor archaeological site: Convent of Santo Domingo (Lugo, Spain)
Authors: Novo Alexandre , Lorenzo Henrique , Rial Fernando I. , Solla Mercedes
Published: August 2010

Indoor archaeological sites are particularly adapted for ground‐penetrating radar (GPR) surveying because the environment is uniform throughout the year. This makes them excellent for the application of meticulous three‐dimensional surveys under repeatable conditions. The objective of this work was to test different dense grid strategies and three‐dimensional imaging techniques in order to improve detection of subfloor targets. Application of the isosurface rendering technique to pseudo‐three‐dimensional volumes resulted in an efficient methodology to map the target in this particular case. This work shows a case history carried out at the convent of Santo Domingo (Lugo, Spain) where a sarcophagus was found. Copyright © 2010 John Wiley & Sons, Ltd.
Organoplatinum(II) Complexes with Nucleobase Motifs as Inhibitors of Human Topoisomerase II Catalytic Activity
Authors: Wang Ping , Leung Chung‐Hang , Ma Dik‐Lung , Lu Wei , Che Chi‐Ming
Published: August 2010

Platinum(II) complexes bearing acetylide ligands containing nucleobase motifs are prepared and their impact on human topoisomerase II (TopoII) is evaluated. Both platinum(II) complexes [PtII(C^N^N)(C≡CCH2R)] (1a,1b,1c) and [PtII(tBu3terpy)(C≡CCH2R)]+(2a,2b,2c) (C^N^N=6‐phenyl‐2,2′‐bipyridyl,tBu3terpy=4,4′,4′′‐tri‐tert‐butyl‐2,2′:6′,2′′‐terpyridyl, and R=(a) adenine, (b) thymine, and (c) 2‐amino‐6‐chloropurine) are stable in aqueous solutions for 48 hours at room temperature. The binding constants (K) for the platinum(II) complexes towards calf thymus DNA are in the order of 105 dm3 mol−1as estimated by using UV/Vis absorption spectroscopy. Of the complexes examined, only complexes1a,1b,1care found to behave as intercalators. Both complexes1a,1b,1cand2a,2b,2cinhibit TopoII‐induced relaxation of supercoiled DNA, while2cis the most potent TopoII inhibitors among the tested compounds. Inhibition of DNA relaxation is detected at nanomolar concentrations of2c. All of the platinum(II) complexes are cytotoxic to human cancer cells with IC50values of 0.5–13.7 μM, while they are less toxic against normal cells CCD‐19 Lu.
Writing manuscripts for publication in scientific journals
Authors: Lin James C.
Published: August 2010

Scientific articles are composed to communicate the motivation for performing the investigation or experiment, and to explain the study design, method of execution, data obtained, and meaning of the results. A standard format, with some variations, is often used in scientific journals that report experimental, clinical, epidemiological, or theoretical investigations. The differences between the sections and guidelines for appropriate information to provide in each section are discussed. Bioelectromagnetics 32:1–3, 2011. © 2010 Wiley‐Liss, Inc.
Human papillomavirus infection and anal dysplasia in renal transplant recipients
Authors: Patel H S , Silver A R , Levine T , Williams G , Northover J M
Published: August 2010

Background

Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including anal squamous cell carcinoma. Additional risk factors for HPV-related disease have not been studied in the renal transplant population. The demographics of anal HPV and associated risk factors were investigated in this population.

Methods

Anal cytology and polymerase chain reaction were used to assess anal HPV disease in a cohort of transplant recipients at the Royal London Hospital. Risk factors associated with increased immunosuppression and HPV exposure were collated to determine any association with anal disease.

Results

Anal dysplasia was associated with anal oncogenic HPV infection (P < 0·001), duration of immunosuppression (P = 0·050), previous genital warts (P = 0·018) and receptive anal intercourse (P = 0·013).

Conclusion

Anal dysplasia was related to immunosuppression and patient factors in this cohort.
Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour
Authors: Hohenberger P , Ronellenfitsch U , Oladeji O , Pink D , Ströbel P , Wardelmann E , Reichardt P
Published: August 2010

Background

This study assessed the outcomes of patients with a gastrointestinal stromal tumour (GIST) that ruptured before or during resection.

Methods

The records of 23 patients (8 women, 15 men; median age 54 years) with ruptured primary non-metastatic GIST were retrieved from a database of 554 patients. The written surgical and pathology reports were analysed. Review pathology was performed in all 23 cases, and mutational analysis of KIT and platelet-derived growth factor α (PDGFRA) genes was performed in 21 patients. Median follow-up was 52 months.

Results

Tumour rupture was spontaneous in 16 patients, following abdominal trauma in two and occurred during resection in five. Primary tumour location was the stomach in six patients, duodenum in one and small bowel in 16. Mean tumour size was 10·2 (range 4–28) cm. According to the Miettinen and Lasota risk classification, the distribution of very low-, low-, intermediate- and high-risk cases was one, two, five and 15 respectively. One patient remained disease-free at 83 months. Fifteen of 16 patients who did not receive adjuvant therapy developed tumour recurrence after a median of 19 months. Median recurrence-free survival in patients with KIT mutations involving codons 557–558 was 11 months.

Conclusion

Patients with a rupture of GIST into the abdominal cavity have a risk of recurrence of nearly 100 per cent. In patients with deletion mutations involving codons 557–558, recurrence-free survival was less than 1 year. All patient groups are clear candidates for adjuvant drug therapy.
Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures
Authors: Chalmers R T A , Darling R C , Wingard J T , Chetter I , Cutler B , Kern J A , Hart J C
Published: August 2010

Background

This study evaluated the safety and haemostatic effectiveness of a fibrin sealant (EVICEL™ Fibrin Sealant (Human)) during vascular surgery.

Methods

This prospective randomized controlled trial compared the haemostatic effectiveness of fibrin sealant (75 patients) or manual compression (72) in polytetrafluoroethylene (PTFE) arterial anastomoses. The primary endpoint was the absence of bleeding at the anastomosis at 4 min after randomization. Secondary endpoints included haemostasis at 7 and 10 min, treatment failures and the incidence of complications potentially related to bleeding. Adverse events were recorded.

Results

A higher percentage of patients who received fibrin sealant versus manual compression achieved haemostasis at 4 min (85 versus 39 per cent respectively; odds ratio 11·34, 95 per cent confidence interval 4·67 to 27·52; P < 0·001). Similarly, a higher percentage of patients who received fibrin sealant achieved haemostasis at 7 and 10 min (both P < 0·001). The incidence of treatment failure was lower in the fibrin sealant group (P < 0·001). The rate of complications potentially related to bleeding was similar (P = 0·426). Some 64 per cent of patients who received fibrin sealant experienced at least one adverse event, compared with 71 per cent who received manual compression.

Conclusion

This fibrin sealant was safe, and significantly shortened the time to haemostasis in vascular procedures using PTFE. Registration number: NCT00154141 (http://www.clinicaltrials.gov).
A Covalently Immobilized Triphenylphosphine Rhodium Complex: Synthesis, Characterization, and Application in Catalytic Olefin Hydrogenation
Authors: Wang Lei , Jia Mingjun , Shylesh Sankaranarayanapillai , Philippi Thomas , Seifert Andreas , Ernst Stefan , Singh Anand Pal , Thiel Werner R.
Published: August 2010

A trimethoxysilane functionalized triphenylphosphine was coordinated to rhodium(I) and the resulting rhodium complex was covalently bound to a mesoporous SBA‐15 support. The catalytic activity of this hybrid material was studied for the hydrogenation of 2‐cyclohexen‐1‐one and compared with the corresponding homogeneous catalyst. According to the 31P‐MAS NMR data, the catalytically active species was stable against oxidation; no structural change could be detected after exposing it to air for more than two months. Transmission electron microscopy (TEM) measurements on the used catalyst confirmed that the rhodium species was also stable against reduction to the metal because the formation of rhodium nanoparticles during the catalysis could be excluded. The kinetic curves of the recycled system confirmed that this hybrid catalyst shows excellent activity, selectivity, stability, and reusability, and is truly heterogeneous in the hydrogenation reaction.
Modular, Homochiral, Porous Coordination Polymers: Rational Design, Enantioselective Guest Exchange Sorption and Ab Initio Calculations of Host–Guest Interactions
Authors: Dybtsev Danil N. , Yutkin Maxim P. , Samsonenko Denis G. , Fedin Vladimir P. , Nuzhdin Alexey L. , Bezrukov Andrey A. , Bryliakov Konstantin P. , Talsi Evgeniy P. , Belosludov Rodion V. , Mizuseki Hiroshi , Kawazoe Yoshiyuki , Subbotin Oleg S. , Belosludov Vladimir R.
Published: August 2010

Two new, homochiral, porous metal–organic coordination polymers [Zn2(ndc){(R)‐man}(dmf)]⋅3DMF and [Zn2(bpdc){(R)‐man}(dmf)]⋅2DMF (ndc=2,6‐naphthalenedicarboxylate; bpdc=4,4′‐biphenyldicarboxylate; man=mandelate; dmf=N,N′‐dimethylformamide) have been synthesized by heating ZnII nitrate, H2ndc or H2bpdc and chiral (R)‐mandelic acid (H2man) in DMF. The colorless crystals were obtained and their structures were established by single‐crystal X‐ray diffraction. These isoreticular structures share the same topological features as the previously reported zinc(II) terephthalate lactate [Zn2(bdc){(S)‐lac}(dmf)]⋅DMF framework, but have larger pores and opposite absolute configuration of the chiral centers. The enhanced pores size results in differing stereoselective sorption properties: the new metal–organic frameworks effectively and stereoselectively (ee up to 62 %) accommodate bulkier guest molecules (alkyl aryl sulfoxides) than the parent [Zn2(bdc){(S)‐lac}(dmf)]⋅DMF, while the latter demonstrates decent enantioselectivity toward precursor of chiral anticancer drug sulforaphane, CH3SO(CH2)4OH. The new homochiral porous metal–organic coordination polymers are capable of catalyzing a highly selective oxidation of bulkier sulfides (2‐NaphSMe (2‐C10H7SMe) and PhSCH2Ph) that could not be achieved by the smaller‐pore [Zn2(bdc){(S)‐lac}(dmf)]⋅DMF. The sorption of different guest molecules (both R and S isomers) into the chiral pores of [Zn2(bdc){(S)‐lac}(dmf)]⋅DMF was modeled by using ab initio calculations that provided a qualitative explanation for the observed sorption enantioselectivity. The high stereo‐preference is accounted for by the presence of coordinated inner‐pore DMF molecule that forms a weak CH⋅⋅⋅O bond between the DMF methyl group and the (S)‐PhSOCH3 sulfinyl group.
From Metallaborane to Borylene Complexes: Syntheses and Structures of Triply Bridged Ruthenium and Tantalum Borylene Complexes
Authors: Geetharani K. , Bose Shubhankar Kumar , Varghese Babu , Ghosh Sundargopal
Published: August 2010

Reaction of [1,2‐(Cp*RuH)2B3H7] (1; Cp*=η5‐C5Me5) with [Mo(CO)3(CH3CN)3] yielded arachno‐[(Cp*RuCO)2B2H6] (2), which exhibits a butterfly structure, reminiscent of 7 sep B4H10. Compound 2 was found to be a very good precursor for the generation of bridged borylene species. Mild pyrolysis of 2 with [Fe2(CO)9] yielded a triply bridged heterotrinuclear borylene complex [(μ3‐BH)(Cp*RuCO)2(μ‐CO){Fe(CO)3}] (3) and bis‐borylene complexes [{(μ3‐BH)(Cp*Ru)(μ‐CO)}2Fe2(CO)5] (4) and [{(μ3‐BH)(Cp*Ru)Fe(CO)3}2(μ‐CO)] (5). In a similar fashion, pyrolysis of 2 with [Mn2(CO)10] permits the isolation of μ3‐borylene complex [(μ3‐BH)(Cp*RuCO)2(μ‐H)(μ‐CO){Mn(CO)3}] (6). Both compounds 3 and 6 have a trigonal‐pyramidal geometry with the μ3‐BH ligand occupying the apical vertex, whereas 4 and 5 can be viewed as bicapped tetrahedra, with two μ3‐borylene ligands occupying the capping position. The synthesis of tantalum borylene complex [(μ3‐BH)(Cp*TaCO)2(μ‐CO){Fe(CO)3}] (7) was achieved by the reaction of [(Cp*Ta)2B4H8(μ‐BH4)] at ambient temperature with [Fe2(CO)9]. Compounds 2–7 have been isolated in modest yield as yellow to red crystalline solids. All the new compounds have been characterized in solution by mass spectrometry; IR spectroscopy; and 1H, 11B, and 13C NMR spectroscopy and the structural types were unequivocally established by crystallographic analysis of 2–6.
ChemInform Abstract: Alkaline Earth Transition Metal Antimonides M1M2 4Sb12 (M1: Ca, Sr, Ba; M2: Fe, Ru, Os) with LaFe4P12‐Structure.
Authors: EVERS C. B. H. , BOONK L. , JEITSCHKO W.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Y‐Ba‐Cu‐O Superconducting Film on Ag Substrate by an Electrophoretic Deposition Method.
Authors: KANG C.‐H. , JEONG C.‐M. , YI C.‐W. , KIM K.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation and Crystal Structure of the Cesium Selenidogermanates(IV) Cs4Ge4Se10×2CH3OH and Cs4Ge2Se8.
Authors: SHELDRICK W. S. , SCHAAF B.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Medium‐Sized Cyclophanes. Part 33. Charge‐Transfer Complexes of 8‐ Methoxy(2.2)metacyclophanes with Tetracyanoethylene.
Authors: YAMATO T. , MATSUMOTO J. , SHINODA N. , IDE S. , SHIGEKUNI M. , TASHIRO M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: IR Linear Dichroic Study of High‐Symmetry Molecules Dissolved in a Liquid Crystal Solvent. Part 2. Metal Hexacarbonyl Complexes M(CO)6 (M: Mo, Cr).
Authors: ROGOJEROV M. I. , ARNAUDOV M. G.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Low Temperature Matrix Isolation Infrared Study of Acetamides. Part 2. Thioacetamide and Some Deuterated Derivatives.
Authors: KNUDSEN R. , SALA O. , HASE Y.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quantum‐Chemical Study of the Acidity of Substituted Acetic Acids with Density Functional Theory Based Descriptors
Authors: DE PROFT F. , AMIRA S. , CHOHO K. , GEERLINGS P.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structures of 1‐(Triphenylstannylmethyl)‐ and 1‐(( Halogenodiphenylstannyl)methyl)‐1,2,4‐triazoles (I).
Authors: COX P. J. , DOIDGE‐HARRISON S. M. S. V. , HOWIE R. A. , WARDELL J. L.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Studies of Pyrimido(2,1‐b)(1,3)thiazine and Thiazolo(3,2‐a) pyrimidine Rings (I) and (II): An X‐Ray and Multinuclear (1H, 13C, 15N) Approach.
Authors: ANTOLINI L. , SCHENETTI L. , RINALDI M. , PECORARI P.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Exploratory Study of Photocyclization Reactions of N‐( Trimethylsilylmethylthioalkyl)phthalimides.
Authors: YOON U. C. , LEE S. J. , LEE K. J. , CHO S. J. , LEE C. W. , MARIANO P. S.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Directed ortho‐Metalation ‐ Cross Coupling Connections. Nickel(0)‐ Catalyzed Cross Coupling of Aryl Triflates with Organozinc Reagents.
Authors: QUESNELLE C. A. , FAMILONI O. B. , SNIECKUS V.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bismuth(III) Halide Catalyzed Tandem Aldol‐Halogenation Reaction: A Convenient Synthesis of β‐Halo Ketones and Esters.
Authors: LE ROUX C. , GASPARD‐ILOUGHMANE H. , DUBAC J.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Potassium Salts of O‐Substituted N‐Nitrohydroxylamines ( IV), (VII).
Authors: KHODOT E. N. , CHLENOV I. E. , TARTAKOVSKII V. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of N,N‐Dibromo‐tert‐butylamine with Ketoximes.
Authors: PETROVA I. M. , CHERTANOVA L. F. , CHLENOV I. E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: β‐Acylvinyl Intermolecular Radical Additions to Double Bonds: Stereoselective Synthesis of Functionalized (E)‐α,β‐ Unsaturated Carboxylic Acids.
Authors: FOUBELO F. , LLORET F. , YUS M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Short and Efficient Synthesis of (2S)‐3‐(1′,1′‐Dimethylethylsulfonyl)‐ 2‐(1‐naphthylmethyl)propionic Acid, N‐Terminal Building Block for Protease Inhibitors.
Authors: HOLLA E. W. , NAPIERSKI B. , REBENSTOCK H.‐P.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase Transfer Catalysis ‐ A Facile Method for Cyclopropanation of Some Isomeric Styryl Benzyl Sulfones and Bis(styryl)sulfones.
Authors: REDDY D. B. , REDDY P. V. R. , SEENAIAH B.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Versatile (3 + 2) Methylenecyclopentane Annulations of Unactivated and Electron‐Rich Olefins with ((Trimethylsilyl)methylene) cyclopropanedicarboxylates.
Authors: HUVAL C. C. , SINGLETON D. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Deoxygenation of Aliphatic Alcohols via Reduction of New Thioxocarbamate Derivatives.
Authors: OBA M. , NISHIYAMA K.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Cleavage of Carboxamides to Carboxylic Acids Using Dinitrogen Tetroxide in the Presence of N‐Bromosuccinimide.
Authors: KIM K. , KIM Y. H.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Z‐3‐Alkylidene‐4,5‐dihydro‐4‐hydroxy‐5‐methyl‐2‐(3H)‐furanones by Regio‐ and Diastereoselective Ene Reaction of Singlet Oxygen (Schenk Reaction) with γ‐Hydroxy Vinylstannanes: An Enantioselective Synthesis of Dihydromahubanolide B.
Authors: ADAM W. , KLUG P.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: α‐Azidonation of Amides, Carbamates, and Ureas with the Iodosylbenzene/Trimethylsilyl Azide Reagent Combination: N‐Acyliminium Ion Precursors.
Authors: MAGNUS P. , HULME C. , WEBER W.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Stereochemistry of Organometallic Compounds. Part 40. Rhodium‐ Catalyzed Reactions of Hydrogen and Carbon Monoxide with Alkenylanilines.
Authors: ANASTASIOU D. , CAMPI E. M. , CHAOUK H. , FALLON G. D. , JACKSON W. R. , MCCUBBIN Q. J. , TRNACEK A. E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.