bluuebunny/crossref_metadata_2025 huggingface dataset:
Metodologias de Pesquisas Pós-Críticas: possibilidades para a saúde e a enfermagem
Authors: Kruse Maria Henriqueta Luce , Cordeiro Franciele Roberta , Oliveira Stefanie Griebeler , Roso Camila Castro
Published: October 2018

Pesquisar. Inventar. Interrogar. Problematizar. Suspeitar. Compor, decompor e recompor. Descrever e analisar. Com esses verbos, iniciamos a reflexão acerca do livro Metodologias de Pesquisas Pós-Críticas em Educação(1). Tais verbos abrangem os modos de fazer e pensar a pesquisa nos referenciais que “fogem”, de algum modo, dos princípios investigativos propostos pela ciência tradicional e positivista, como a racionalidade, a universalidade, a objetividade, e a neutralidade.
Aplicação da escala reduzida de autoeficácia em amamentação no contexto da Estratégia Saúde da Família
Authors: Soares Lorena Sousa , Da Silva Grazielle Roberta Freitas , Gouveia Márcia Teles de Oliveira , Brandão Erlayne Camapum , Oriá Mônica Oliveira Batista
Published: October 2018

Resumo: O objetivo do estudo foi avaliar a auto-eficácia em amamentação por meio da aplicação da Breastfeeding Self-Efficacy Scale – Short Form, junto a 39 mães, na cidade de Teresina (PI). Resultados mostraram eficácia alta e média, não existindo assim, eficácia baixa neste estudo. Na análise separada dos itens, os menores índices foram nos itens: 6 e 13, quanto à categoria técnica. No domínio intrapessoal, os menores índices foram nos itens: 2, 8 e 10. Identificando as mães que tem menor auto-eficácia e maior risco para o desmame precoce, o profissional pode avaliar e programar a sua promoção ao aleitamento materno.Descritores: Aleitamento Materno, Validade dos Testes, Enfermagem em Saúde Comunitária.Reduced scale application of self-efficacy in breast feeding in the context of family health strategyAbstract: The purpose of this study was to evaluate self-efficacy in breastfeeding through the application of Breastfeeding Self-Efficacy Scale - Short Form, along with 39 mothers, in the city of Teresina (PI). Results showed average and high efficiency, so there is, low efficiency in this study. In separate analysis of scale items, the lowest levels were the following items: 6 and 13 about the technical category. In the intrapersonal domain, the lowest rates were in the items: 2, 8 and 10. Identifying mothers who have lower self-efficacy and higher risk for early weaning, the practitioner can assess and plan its promotion of breastfeeding.Descriptors: Breast Feeding, Validity of Tests, Community Health Nursing.Reuccion de aplicación a gran escala de autoeficacia en la lactaricia materna en el contexto de la estrategia de salud de la família.Resumen: El propósito de este estudio fue evaluar la autoeficacia en la lactancia materna a través de la aplicación de Breastfeeding Self-Efficacy Scale - Short Form, entre 39 madres de la ciudad de Teresina (PI). Los resultados mostraron una alta eficacia y la media, por lo que es, una baja eficacia en este estudio. En un análisis separado de los elementos, el más bajo en los artículos fueron: 6 y 13, como la categoría de técnico. En el dominio intrapersonal, las tasas más bajas en los artículos: 2, 8 y 10. La identificación de madres que tienen menor riesgo de auto-eficacia y el aumento de destete precoz, el médico puede evaluar y planificar la promoción de la lactancia.Descriptores: Lactancia materna, Validez de las pruebas, Enfermería en Salud Comunitaria.
Significado e valores relacionados ao trabalho para mulheres integrantes das equipes de enfermagem de diferentes gerações
Authors: Vieira Adriane
Published: October 2018

Resumo: Este estudo teve como objetivo analisar os significados e valores relacionados ao trabalho para mulheres de diferentes gerações etárias, membros das equipes de enfermagem de um hospital geral, de caráter privado. Estudo de caso com a técnica de entrevista semi-estruturada. Os resultados apontam que o trabalho é predominantemente percebido como um sacro-ofício, e que existem sutis diferenças de percepção entre as gerações quanto aos valores relativos ao trabalho. Conclui-se pela necessidade da realização de estudos quantitativos com estratificação socioeconômica da amostra.Descritores: Enfermeiras; Relação entre Gerações; Trabalho; Recursos Humanos.Meaning and values related to work for nurses of different generationsAbstract: This study aimed to analyze the meaning and values related to work for women of different generations age, members of the nursing staff of a private general hospital. Case study with the technique of semi-structured interview. The results indicate that work is predominantly perceived as a sacro-craft, and there are subtle differences in perception between generations about the values for the job. It concludes the necessity of quantitative studies with socioeconomic stratification of the sample.Descriptors: Nurses; Intergenerational Relations; Work; Human Resources.Significado y valores relativos al trabajo para enfermeras de distintas generacionesResumen: Este estudio tuvo como objetivo analizar el significado y los valores relacionados con el trabajo para las mujeres de diferentes generaciones etarias, miembros del personal de enfermería de un hospital general, de carácter privado. Estudio de caso con la técnica de la entrevista semi-estructurada. Los resultados indican que el trabajo es predominantemente percibido como un sacro-oficio, y hay diferencias sutiles en la percepción entre las generaciones sobre los valores para el trabajo. Se concluye la necesidad de estudios cuantitativos con la estratificación socioeconómica de la muestra.Descriptores: Enfermeras; Relaciones Intergeneracionales; Trabajo; Recursos Humanos.
Síndrome de Burnout em enfermagem pediátrica e neonatal: revisão da literatura
Authors: Tito Renata Santos , Baptista Patrícia Campos Pavan , Da Silva Fábio José , De Carvalho Marissol Bastos , Da Silva Silmar Maria
Published: October 2018

Resumo: A síndrome de burnout é caracterizada pelo esgotamento físico e emocional do trabalhador. Foi realizado levantamento da literatura dos últimos 5 anos sobre esta síndrome em enfermagem pediátrica e neonatal. Optou-se pela revisão integrativa da literatura nas bases de Dados: Medline, Cinahl, Lilacs, Dedalus e Scopus. A amostra dessa revisão foi constituída por 13 estudos, dos quais emergiram três categorias temáticas: sofrimento do profissional, características individuais e suporte Institucional. Os dados revelam necessidade de realização de estudos neste campo de atuação com fortes níveis de evidência para subsidiar a saúde do trabalhador de enfermagem.Descritores: Enfermagem, Enfermagem Pediátrica, Enfermagem Neonatal, Esgotamento Profissional.Burnout syndrome in pediatric and neonatal nursing: a literature reviewAbstract: Burnout syndrome is characterized by physical and emotional exhaustion of workers. We performed a literature of the last 5 years about this syndrome in pediatric and neonatal nursing. We opted for an integrative literature review of data bases: Medline, Cinahl, Lilacs, Dedalus and Scopus. The sample of this review consisted of 13 studies, which revealed three themes: Suffering of the workers, individual characteristics and Institutional Support. The data show the need for studies in this field of work with strong levels of evidence to support worker health nursing.Descriptors: Nursing, Pediatric Nursing, Neonatal Nursing, Burnout, Professional.El síndrome de burnout en enfermagem pediatrica y neonatal: una revisión de la literaturaResumen: El síndrome de Burnout se caracteriza por agotamiento físico y emocional de los trabajadores. Se realizó un levantamiento de la literatura de los últimos 5 años sobre éste síndrome en enfermería pediátrica y neonatal. Se optó por una revisión integradora de la literatura de las bases de datos: Medline, CINAHL, LILACS, Dedalus y Scopus. La muestra consistió en 13 estudios, de los cuales surgieron tres categorías temáticas: sufrimiento del profesional, características individuales y apoyo Institucional. Los datos muestran la necesidad de realizar estudios con fuertes niveles de evidencia en éste campo para apoyar la salud del trabajador de enfermería.Descriptores: Enfermería, Enfermería Pediátrica, Enfermería Neonatal, Agotamiento Profesional.
Sobrepeso e obesidade em adolescentes de escolas públicas
Authors: Araújo Eline Saraiva Silveira , Guedes Maria Vilani Cavalcante , Almeida Paulo César
Published: October 2018

Resumo: Objetivou-se verificar a frequência de obesidade e sobrepeso em adolescentes de escolas públicas por meio da idade e antropometria. Estudo transversal com 660 alunos, com idade de 12 a 19 anos, cuja coleta ocorreu em março de 2012. Dos adolescentes, 344 (52,1%) eram meninas. A média de idade dos escolares situou-se entre 16 ± 1,7ano, com amplitude de variação de 12 a 19 anos. A maioria, 541 (82%), apresentou IMC saudável, porém 86 (13%) foram considerados de risco de sobrepeso ou sobrepeso. Urge refletir e explorar a problemática, mediante desenvolvimento de atividades de prevenção e ações interventivas nos casos encontrados.Descritores: Adolescente, Antropometria, Sobrepeso, ObesidadeOverweight and obesity among adolescents in public schoolsAbstract: We aimed to verify the frequency of obesity and overweight in adolescents from public schools through age and anthropometry. A crosssectional study with 660 students, aged from 12-19 years, whose data collection happened in March 2012. From the adolescents, 344 (52.1%) were female. The average age of the students was 16 ± 1.7 year, ranging from 12 to 19 years. The majority, 541 (82%), presented healthy BMI, however 86 (13%) were considered at risk for overweight or overweight. There is urgent need to reflect and explore the issue by developing preventive activities and interventional actions in the cases found.Descriptors: adolescent. Anthropometry, Overweight, obesitySobrepeso y obesidad en adolescentes de escuelas públicas.Resumen: El objetivo fue verificar la frecuencia de obesidad y sobrepeso en adolescentes de escuelas públicas por edad y antropometría. Estudio transversal, con 660 alumnos, de 12 a 19 años, en marzo de 2012. De los adolescentes, 344 (52,1%) eran niñas. El promedio de edad estuvo entre 16 ± 1,7 año, con rango de variación entre 12 y 19 años. La mayoría, 541 (82%), presentó IMC saludable, pero 86 (13%) se consideraron en riesgo de sobrepeso o sobrepeso. Es preciso reflexionar y estudiar la problemática a través del desarrollo de actividades de prevención y acciones de intervención en los casos encontrados.Descriptores: adolescente, Antropometría, Sobrepeso, Obesidad
Simulação na formação e na qualificação do profissional de enfermagem
Authors: Vargas Mara Ambrosina de Oliveira
Published: October 2018

Simulação é uma pedagogia que utiliza um ou mais estratégias para promover, melhorar ou validar conhecimentos, dos participantes por meio da aprendizagem baseada na experiência.
Enfermagem frente à reabilitação de pacientes submetidos à amputação
Authors: Mariano Daiane , Leal Sandra Maria Cezar , Soares Joannie dos Santos Fachinelli
Published: October 2018

Resumo: investigar como a enfermagem enfrenta o cuidado ao paciente submetido à amputação de extremidades e quais as ações que contribuempara reabilitação após a alta hospitalar. Método: estudo qualitativo, análise temática. Questões norteadoras: Como a enfermagem enfrenta o cuidadoao paciente com amputação? Os cuidados durante a hospitalização podem contribuir para reabilitação após a alta hospitalar? Coleta com entrevistasgravadas, com 10 profissionais da equipe de enfermagem de uma rede hospitalar pública, Porto Alegre/RS. Porto Alegre/RS. Resultados: na análiseemergiram as duas categorias: características dos pacientes amputados; A equipe de enfermagem frente ao cuidado do paciente amputado. Conclusão: acriação de protocolo sistematizado de atendimento e a revisão do sistema de suporte no pós-alta, pode contribuir para a reabilitação da pessoa amputada.Descritores: Amputação; Enfermagem; Hospitalização; Cuidados de Enfermagem.Nursing facing rehabilitation of patients submitted to amputationAbstract: investigate how nursing care faces the care to the patient with amputation of the extremities and which actions contribute for the re-habilitationafter the hospital discharge. Method: qualitative study and thematic analysis. Guiding questions: How does nursing face the care to the patient withamputation? Can the care given during the hospitalization contribute for the re-habilitation after the hospital discharge? Collection with recordedinterviews, signature of free and cleared up consent statements, in October 2011, with 10 professionals of the nursing staff from a public hospitalnetwork, Porto Alegre-RS. Results: two categories derived from the analysis: Characteristics of the amputated patients; The nursing staff facing the careto the amputated patient. Conclusion: the creation of a systematized attendance protocol and the revision of the support system in the post-dischargecan contribute for the amputated subject re-habilitation.Descriptors: Amputation; Nursing; Hospitalization; Nursing Care.Enfermería ante la rehabilitación de pacientes sometidos a amputaciónResumen: investigar como la enfermería enfrenta el cuidado al paciente sometido a amputación de extremidades y las acciones que contribuyen para larehabilitación tras el alta hospitalaria. Método: estudio cualitativo, análisis temático. Cuestiones orientadoras: ¿Cómo la enfermería enfrenta el cuidadoal paciente con amputación? ¿Pueden los cuidados durante la hospitalización contribuir para la rehabilitación tras el alta hospitalaria? Recolección conentrevistas grabadas, firma de declaraciones de consentimientos libres y esclarecidos, en octubre 2011, con 10 profesionales del equipo de enfermeríade una red hospitalaria pública, Porto Alegre-RS. Resultados: del análisis surgieron dos categorías: Características de los pacientes amputados; El equipode enfermería frente al cuidado del paciente amputado. Conclusión: creación de protocolo sistematizado de atendimiento y la revisión del sistema
Percepção de mães sobre o uso de práticas integrativas e complementares em seus filhos
Authors: Fortes Jessica Andressa Monteiro Saraiva , Santos Lucas De Souza , Moraes Samara Dourado Dos Santos
Published: October 2018

Resumo:Este estudo teve como objetivos descrever as práticas integrativas e complementares pelas mães em seus filhos, identificar motivos que aslevam ao uso e discutir a percepção de mães sobre essas práticas. Pesquisa qualitativa, realizada em um Centro de Saúde de Teresina-PI, com 10 mãesde crianças menores de 5 anos. Essas percebem massagem, xarope, orações de maneira positiva a insatisfação com a medicina tradicional, crenças ecultura os motivos que as levam a utilização. São necessárias orientações e assistência integral as mães, enfocando o uso racional dessas práticas nasaúde da criança.Descritores: Terapias Complementares; Saúde da Criança; Enfermagem.Mothers’ perception about the use of integrative and complementary practices in their children.Abstract: This study aimed to describe the complementary and integrative practices by mothers on their children, to identify reasons that lead to theuse and discuss the perceptions of mothers about such practices. Qualitative research conducted in a Health Centre of Teresina-PI, with 10 mothers ofchildren under 5 years. They perceive massage, syrup, prayers positively dissatisfaction with traditional medicine, cultural beliefs and the reasons thatlead them to use. Guidelines are necessary and integral care mothers, focusing on the rational use of these practices on children’s health.Descriptors: Complementary Therapies, Child Health, Nursing.La percepción de las madres sobre el uso de prácticas complementarias y de integración en sus hijosResumen: Este estudio tuvo como objetivo describir las prácticas complementarias y de integración de las madres sobre sus hijos, para identificar lasrazones que conducen a la utilización y analizar las percepción cualitativa realizada en un Centro de Salud de Teresina-PI, com 10 madres de niñosmenores de 5 anõs. Ellos perciben El masaje, el jarabe, las oraciones de una manera positiva la insatisfacción com la medicina tradicional, las creenciasculturales y las razones que lês llevan a utilizar. Directrices son madres de cuidado necesarias e integral, centrado en el uso racional de estas prácticasem la salud de los niños.Descriptores: Terapias Complementarias; La Salud Infantil; Enfermería.
Vulnerabilidade dos usuários de crack à infecção pelo vírus da imunodeficiência humana
Authors: De Araújo Telma Maria Evangelista , Sousa Anderson Da Silva , Clementino Rafael Alves , De Sá Laís Carvalho , De Lima Sângela Medeiros
Published: October 2018

Resumo: Objetivou-se investigar a vulnerabilidade dos usuários de crack cadastrados nos Centro de Atenção Psicossocial Álcool e Drogas (CAPSad) doPiauí, com relação à infecção pelo Human Imunodeficiency Vírus (HIV). Trata-se de um inquérito epidemiológico, realizado nos CAPSad do Piauí, com343 usuários. Predominaram o sexo masculino, com média de idade de 29,2 anos. Os fatores de riscos predominantes foram múltiplos parceiros sexuais,uso de álcool e drogas antes do sexo, história de prisão e tatuagem. Conclui-se que os usuários de crack constituem um grupo com a susceptibilidadeaumentada à infecção pelo vírus HIV, devido comportamentos de risco por eles assumidos.Descritores: HIV. Cocaína crack. Vulnerabilidade.Vulnerability of crack users to the infection by human imunodeficiency virusAbstract: The aim of this work was to investigate the vulnerability of crack users enrolled in Psychosocial Care Center Alcohol and Drugs (CAPSad) Piauí,with respect to infection Imunodeficiency Human Virus (HIV). This is a survey carried out in CAPSad the state of Piaui, with 343 users. A predominanceof male sex with mean age of 29.2 years. The risk factors were predominant multiple sexual partners, use of alcohol and drugs before sex, and historyof prison tattooing. It is concluded that crack users are a group with increased susceptibility to HIV infection, risk behaviors because they assumed.Descriptors: HIV. Crack cocaine. Vulnerability.Vulnerabilidad de los consumidores de crack a la infección por el virus human imunodeficiencyResumen: El objetivo era investigar la vulnerabilidad de los consumidores de crack inscrito en Alcohol Centro de Atención Psicosocial y Drogas (CAPSad)Piauí, con respecto a la infección del Virus Imunodeficiency Humana (VIH). Se trata de un estudio llevado a cabo en CAPSad el estado de Piauí, con 343usuarios. Se identificó predominio de hombres del sexo masculino, con una edad media de 29,2 años. Los factores de riesgo predominantes fueronmúltiples parejas sexuales, uso de alcohol y drogas antes de tener sexo, y la historia de los tatuajes prisión. Se concluye que los usuarios de crack sonun grupo con una mayor susceptibilidad a la infección por VIH, las conductas de riesgo, ya que se supone.Descriptores: VIH. Cocaína crack. Vulnerabilidad.
Perfil de saúde e qualidade de vida de idosos de Santa Juliana-MG
Authors: Santos Álvaro Da Silva , Meneguci Joilson , Da Silveira Rodrigo Eurípedes , Marquez Fernanda Avelar , Ferreira Verônica Aparecida , Viana Dayane Aparecida
Published: October 2018

Resumo: Estudo quantitativo que analisou o perfil de saúde e qualidade de vida da população idosa do município de Santa Juliana-MG. Entre os207 idosos, 53,6% eram mulheres, com idade média de 70±7,5 anos. 56% vivem com companheiro e 78,7% são aposentados. A Hipertensão Arterial,a cardiopatia e doenças reumáticas foram as mais relatadas e com relação à qualidade de vida, o domínio meio ambiente era o mais prejudicado. Apesquisa aponta a necessidade de ações de promoção e educação em saúde tendo como foco o autocuidado, a prevenção de agravos e incorporandoestratégias de atenção social ao idoso.Descritores: Perfil de saúde, Idoso, Qualidade de vida.Health profile and quality of life of the elderly in Santa Juliana (MG)Abstract: Quantitative study that examined the health profile and quality of life of the elderly population of the municipality of Santa Juliana-MG.Among the 207 individuals, 53.6% were women, aged about 70 ± 7.5 years. 56% live with companion and 78.7% are retired. High blood pressure, heartdisease and rheumatic diseases were the most reported and with regard to the quality of life, the environment was the most affected. This research pointsthe need for promotional and health education focusing the self-care, prevention of diseases and social attention strategies incorporating the elderly.Descriptors: Health profile; Aged; Quality of life.Perfil de salud y calidad de vida de los ancianos de Santa Juliana (MG)Resumen: Estudio cuantitativo que examina el perfil de salud y la calidad de vida de la población anciana del municipio de Santa Juliana-MG. Entre los207 individuos, 53,6% eran mujeres, con edad media de 70 ± 7,5 años. 56% vive con acompañante y 78.7% son aposentados. La presión arterial alta,enfermedades del corazón y enfermedades reumáticas fueron las más reportadas y con respecto a la calidad de vida, el medio ambiente fue el dominiomás afectado. Esa investigación apunta la necesidad de promoción y educación para la salud centrándose en autocuidado, prevención de enfermedadesy estrategias de atención social incorporando los ancianos.Descriptores: Perfil de salud; Anciano; Calidad de vida.
MAIS UMA VEZ QUESTIONA-SE: E O IMPACTO DA PESQUISA NA PRÁTICA DA ENFERMAGEM?
Authors: Lunardi Valéria Lerch
Published: October 2018

Atualmente, a área da Enfermagem, no CNPq, tem 167 bolsistas de produtividade em pesquisa; na CAPES, são 67 Programas, com 33 cursos de doutorado, 50 de mestrado acadêmico e 15 de mestrado profissional(1). No triênio 2010-2012, esses Programas relataram à CAPES a publicação de 9.206 artigos, sendo 2.787 em periódicos Qualis A, ocupando o sexto lugar em produção na área, superados apenas pelos Estados Unidos, Reino Unido, Austrália, França e Canadá(2). Assim, temos muito a comemorar e do que nos orgulhar quanto ao crescimento e desenvolvimento da Enfermagem, especialmente, quanto aos avanços na formação de recursos humanos e produção científica.
COMPETÊNCIA LEGAL DO ENFERMEIRO NA URGÊNCIA/ EMERGÊNCIA
Authors: Filho Luiz Alves Morais , Martini Jussara Gue , Vargas Mara Ambrosina De Oliveira , Reibnitz Kenya Schmidt , Bitencourt Julia Valeria De O. V. , Lazzari Danielle
Published: October 2018

Objetivo: o estudo buscou conhecer quais procedimentos/aspectos/situações relacionados aos serviços de urgência/emergência foram objeto de regulamentação pelos conselhos de Enfermagem. Metodologia: estudo descritivo exploratório com abordagem qualitativa e documental, realizado em setembro de 2013. A fonte constituiu-se das Resoluções/Pareceres/Decisões do Sistema dos Conselhos de Enfermagem. Foram selecionadas três resoluções, 51 pareceres e sete decisões. Resultados: os dados foram agrupadas em três categorias temáticas: procedimentos que são e procedimentos que não são de competência legal do enfermeiro na urgência/ emergência; e procedimentos que são de competência legal apenas em risco iminente de morte. Conclusão: o exame da legislação apontou a necessidade de uma maior regulamentação do exercício profissional e formação nessa área.Descritores: Enfermagem, Legislação de Enfermagem, Emergências.LEGAL COMPETENCE OF EMERGENCY NURSESObjective: the study aimed to know which procedures/issues/situations related to urgency/emergency services were subject to regulation by the boards of nursing. Methodology: descriptive exploratory study with qualitative and documentary approach, held in September 2013. The supply consisted of Resolutions/Opinions/Decisions of Nursing Councils system, being selected three resolutions, 51 opinions and seven decisions. Results: the data were grouped into three thematic categories: Procedures that are, and procedures that are not legal nurse competence in urgent/emergency; and procedures that are only at risk of imminent death. Conclusion: the review of the legislation pointed to the need for greater regulation of professional practice and training in this area.Descriptors: Nursing, Legislation Nursing, Emergencies.COMPETENCIA LEGAL DEL ENFERMERO EN LA URGENCIA/EMERGENCIAObjetivo: el estudio buscó conocer qué procedimientos/problemas/situaciones relacionadas con urgencia/servicios de emergencia estaban sujetos a regulación por parte de los consejos de administración de enfermería. Metodologia: estudio exploratorio descriptivo con enfoque cualitativo y documental, que tuvo lugar en septiembre de 2013. La oferta consistía en Resoluciones/opiniones/decisiones del sistema de Consejos de Enfermería. Seleccionaron tres resoluciones, 51 opiniones y siete decisiones. Resultados: los dados se agrupan en tres categorías temáticas: los procedimientos que son, y procedimientos que no sean competencia legal de la enfermera con urgencia / emergencia; y los procedimientos que sólo están en riesgo de muerte inminente. Conclusión: la revisión de la legislación señaló la necesidad de una mayor regulación de la práctica profesional y la formación en esta área.Descriptores: Enfermería, Legislación de Enfermería, Urgencias Médicas.
REPRESENTAÇÕES DO CUIDADO NO LIMIAR DA VIDA POR PROFISSIONAIS DE UMA UNIDADE DE TERAPIA INTENSIVA MÓVEL
Authors: Do Nascimento Keyla Cristiane , Erdmann Alacoque Lorenzini , Do Nascimento Eliane Regina Pereira , Dos Santos José Luis Guedes
Published: October 2018

Objetivo: esta é uma pesquisa qualitativa que buscou compreender as representações do cuidado de pessoas no limiar da vida. Método: foi realizado com profissionais de saúde de uma Unidade de Terapia Intensiva (UTI) móvel. Os dados foram coletados com entrevistas a 18 participantes (enfermeiros e médicos) e analisados conforme etapas da codificação da Teoria Fundamentada nos Dados. Resultados: o tema central identificado foi: representações do cuidado no limiar da vida, com duas categorias: sentido do cuidado no limite da vida e UTI móvel como espaço do cuidar. Conclusão: o cuidado no limiar da vida precisa ser vivido em seu sentido mais amplo e integral pelos profissionais de saúde.Descritores: Enfermagem, Cuidados Intensivos, Unidade de Terapia Intensiva.Representations of the care on the threshold of life by health care professionals in mobile Intensive Care Unit.Objective: this is a qualitative study with the aim to comprehend care representations for people on the threshold of life. Method: it was conducted with health professionals of the mobile Intensive Care Unit (ICU) mobile. The data was collected through interviews with eighteen participants (nurses and physicians) and the data was analyzed using the codification steps from Grounded Theory. Results: the central theme obtained was: Care Representations on the threshold of life, with two categories: the sense of care on the threshold of life and the Mobile ICU as a space for care. Conclusion: care on the threshold of life needs to be lived in its broadest sense and whole by health professionals.Descriptors: Nursing, Intensive Care, Intensive Care Unit.Representaciones del cuidado en el umbral de la vida por los profesionales de la salud que trabajan en una Unidad de Terapia Intensiva móvil.Objetive: se trata de Investigación cualitativa que tuve como objetivo de comprender las representaciones del cuidado a las personas en el umbral de la vida. Método: se llevó a cabo con los profesionales de la salud que trabajan en una Unidad de Terapia Intensiva móvil. Se entrevistaron dieciocho profesionales (enfermeras y médicos) y los datos se analizaron según las etapas de codificación de la Teoría Fundamentada. Resultados: el tema central identificado fue: las representaciones del cuidado en el umbral de la vida, con dos categorías: el sentido del cuidado en el umbral de la vida y la UCI móvil como un espacio del cuidado. Conclusión: cuidado en el umbral de la vida tiene que ser vivida en su sentido más amplio y completo por profesionales de la salud.Descriptores: Enfermería, Cuidados Intensivos, Unidad de Cuidados Intensivos.
PRÁTICAS SEGURAS PARA ADMINISTRAÇÃO DE MEDICAMENTOS: CONSTRUÇÃO E VALIDAÇÃO DE INSTRUMENTO
Authors: De Souza Mônica Jordão , Real Daniel Sundfeld Spiga , Cunha Isabel Cristina Kowal Olm , Bohomol Elena
Published: October 2018

Objetivo: Construir e validar um instrumento de avaliação do processo de administração de medicamentos. Metodologia: Utilizou-se um desenho não experimental e a sequência da pesquisa metodológica, ou seja, definição do construto, formulação dos itens, avaliação da confiabilidade e avaliação da validade de conteúdo. Resultado: Obteve-se um instrumento com 54 itens divididos em 10 áreas, com nível de concordância entre 90 a 100% e Alpha de Cronbach de 0,94. Conclusão: Pode afirmar-se que o instrumento final é um material de qualidade, que permite o monitoramento dos processos de trabalho que interferem na ocorrência de erros de administração de medicamentos.Descritores: Erros de Medicação; Sistemas de Medicação; Segurança do Paciente; Estudos de Avaliação.SAFE PRACTICES FOR MEDICATION ADMINISTRATION: INSTRUMENT CONSTRUCTION AND VALIDATION.Objective: Construct and validate an instrument for evaluating the medication administration process. Method: We used a non-experimental design and the sequence of the methodological research, that is, the definition of the construct, formulation of the items, evaluation of reliability and evaluation of the content validity. Result: An instrument was obtained with 54 items divided into 10 areas, with a level of agreement between 90 and 100% and Cronbach’s Alpha of 0.94. Conclusion: It can be stated that the final instrument is a quality material, which allows the monitoring of work processes that interfere in the occurrence of medication administration errors.Descriptors: Medication Errors, Medication Systems, Patient Safety, Evaluation Studies.PRÁCTICAS SEGURAS PARA LA ADMINISTRACIÓN DE DROGAS: CONSTRUCCIÓN Y VALIDACIÓN DE INSTRUMENTOS.Objetivo: Construir y validar un instrumento de evaluación del proceso de administración de medicamentos. Método: Se utilizó un diseño no experimental y la secuencia de la metodología de búsqueda, o construir formulación definición de artículos, la evaluación fiabilidad y la evaluación de la validez del contenido. Resultado: Se obtiene un instrumento con 54 ítems divididos en 10 zonas, con el grado de concordancia entre el 90-100% y Alpha de Cronbach de 0,94. Conclusión: Se puede decir que el instrumento final es un material de calidad, lo que permite el seguimiento de los procesos de trabajo que influyen en la aparición de errores de administración de medicamentos.Descriptores: Errores de Medicación; Sistemas de Medicación; Seguridad del Paciente; Estudios de Evaluación
EXAME DE SUFICIÊNCIA PARA ENFERMAGEM: DEFESA DA SAÚDE DA POPULAÇÃO E DA DIGNIDADE DA PROFISSÃO POR QUEM TEM CONHECIMENTO
Authors: Da Silva Manoel Carlos Neri , De Humerez Dorisdaia Carvalho
Published: October 2018

A Enfermagem é profissão regulamentada pela Lei Nº 7498/86, definidas suas competências mínimas e áreas de atuação. A regulação e o controle do exercício profissional é a função dos Conselhos de Enfermagem.
Current Development of Metal Complexes with Diamine Ligands as Potential Anticancer Agents
Authors: Misirlic-Dencic Sonja , Poljarevic Jelena , Isakovic Andjelka M. , Sabo Tibor , Markovic Ivanka , Trajkovic Vladimir
Published: October 2018

Background::

The discovery of cisplatin and the subsequent research revealed the importance
of dinitrogen-containing moiety for the anticancer action of metal complexes. Moreover, certain
diamine ligands alone display cytotoxicity that contributes to the overall activity of corresponding
complexes.

Objective::

To summarize the current knowledge on the anticancer efficacy, selectivity, and the mechanisms
of action of metal complexes with various types of diamine ligands.

Method::

The contribution of aliphatic acyclic, aliphatic cyclic, and aromatic diamine ligands to the
anticancer activity and selectivity/toxicity of metal complexes with different metal ions were analyzed
by comparison with organic ligand alone and/or conventional platinum-based chemotherapeutics.

Results::

The aliphatic acyclic diamine ligands are present mostly in complexes with platinum. Aliphatic
cyclic diamines are part of Pt(II), Ru(II) and Au(III) complexes, while aromatic diamine ligands
are found in Pt(II), Ru(II), Pd(II) and Ir(III) complexes. The type and oxidation state of metal ions
greatly influences the cytotoxicity of metal complexes with aliphatic acyclic diamine ligands. Lipophilicity
of organic ligands, dependent on alkyl-side chain length and structure, determines their cellular
uptake, with edda and eddp/eddip ligands being most useful in this regard. Aliphatic cyclic diamine
ligands improved the activity/toxicity ratio of oxaliplatin-type complexes. The complexes with aromatic
diamine ligands remain unexplored regarding their anticancer mechanism. The investigated complexes
mainly caused apoptotic or necrotic cell death.

Conclusion::

Metal complexes with diamine ligands are promising candidates for efficient and more
selective alternatives to conventional platinum-based chemotherapeutics. Further research is required to
reveal the chemico-physical properties and molecular mechanisms underlying their biological activity.
Natural Compounds Therapeutic Features in Brain Disorders by Experimental, Bioinformatics and Cheminformatics Methods
Authors: Avram Speranta , Puia Alin , Udrea Ana Maria , Mihailescu Dan , Mernea Maria , Dinischiotu Anca , Oancea Florin , Stiens Johan
Published: October 2018

Background::

Synthetic compounds with pharmaceutical applications in brain disorders
are daily designed and synthesized, with well first effects but also seldom severe side
effects. This imposes the search for alternative therapies based on the pharmaceutical potentials
of natural compounds. The natural compounds isolated from various plants and arthropods
venom are well known for their antimicrobial (antibacterial, antiviral) and antiinflammatory
activities, but more studies are needed for a better understanding of their structural
and pharmacological features with new therapeutic applications.

Objectives::

Here we present some structural and pharmaceutical features of natural compounds
isolated from plants and arthropods venom relevant for their efficiency and potency in
brain disorders. We present the polytherapeutic effects of natural compounds belonging to
terpenes (limonene), monoterpenoids (1,8-cineole) and stilbenes (resveratrol), as well as natural
peptides (apamin, mastoparan and melittin).

Methods::

Various experimental and in silico methods are presented with special attention on
bioinformatics (natural compounds database, artificial neural network) and cheminformatics
(QSAR, drug design, computational mutagenesis, molecular docking).

Results::

In the present paper we reviewed: (i) recent studies regarding the pharmacological
potential of natural compounds in the brain; (ii) the most useful databases containing molecular
and functional features of natural compounds; and (iii) the most important molecular descriptors
of natural compounds in comparison with a few synthetic compounds.

Conclusion::

Our paper indicates that natural compounds are a real alternative for nervous
system therapy and represents a helpful tool for the future papers focused on the study of the
natural compounds.
The Mechanism of Action of Praziquantel: Six Hypotheses
Authors: Thomas Charlotte M. , Timson David J.
Published: October 2018

Despite being one of the most commonly used drugs, the molecular mechanism of action of
the anthelmintic praziquantel remains unknown. There are some unusual features of this drug. Critically,
widespread resistance to praziquantel has not developed despite decades of use. Here, we set out some
challenges in praziquantel research and propose some provocative hypotheses to address these. We suggest
that praziquantel may have multiple pharmacologically relevant targets and the effects on these may
synergise to produce an overall, detrimental effect on the parasite. Praziquantel also acts on a number of
host proteins and we propose that these actions are important in the drug’s overall mechanism. Although
the drug is largely used in the treatment of human and domestic animal worm infections, there is a considerable
“grey literature” along with some academic studies which may have been overlooked. It appears
that praziquantel may be effective against hydra. It may also be effective against some unicellular
parasites such as Giardia spp. Further, scientific work on these understudied areas may be useful in understanding
the molecular mechanism in Trematoda. The lack of widespread resistance suggests that
praziquantel may act, at least in part, on a protein-protein interaction. Altered drug metabolism or enhanced
drug efflux are the most likely ways resistance may arise. There is a critical need to understand
the biochemical pharmacology of this drug in order to inform the discovery of the next generation of
anthelmintic drugs.
Placebo Effect in Obsessive-Compulsive Disorder (OCD). Placebo Response and Placebo Responders in OCD: The Trend Over Time
Authors: Kotzalidis Georgios D. , Del Casale Antonio , Simmaco Maurizio , Pancheri Lucia , Brugnoli Roberto , Paolini Marco , Gualtieri Ida , Ferracuti Stefano , Savoja Valeria , Cuomo Ilaria , De Chiara Lavinia , Mosca Alessio , Sani Gabriele , Girardi Paolo , Pompili Maurizio , Rapinesi Chiara
Published: October 2018

Background:

Placebo response appears to be increasing in antidepressant, antipsychotic
and various internal medicine trials. A similar trend has been reported for OCD during 1989-1999.
Placebo response is generally considered as the extent to which placebo treatment is associated with
core symptom improvement. In this analysis, we used Joinpoint regression to assess the time trend
of both placebo response and placebo responder rates according to the year of publication with no
time restriction in OCD drug trials.

Methods:

We included drug and/or psychotherapy trials vs. placebo from PubMed, Embase,
CINAHL, and PsycINFO retrieved through the search (placebo OR sham) AND (obsessive* OR
OCD). We included studies through investigator consensus. We then performed on data of included
studies log-linear joinpoint segmented regression models using a p<0.05 cutoff.

Results:

We included 113 studies from 112 published papers. Placebo mean annual response rates
in OCD studies significantly increased from 1991 to 2017 with an annual percent change (APC) of
0.66%, while placebo mean annual responder rates also significantly increased from 2010 to 2017,
with an APC of 5.45%. Drug mean annual response rates in OCD studies significantly increased
from 1987 to 2012 with an APC of 0.72%, while the corresponding responder rates did not show
statistically significant APC changes between 1984 and 2017.

Conclusion:

We observed a tendency for placebo to increase both measures of response in OCD
clinical drug trials through the years that tend to approximate the responses shown by drugs. Changes
in the type of study (moving from classical head to head comparisons to add-on studies in treatmentresistant
populations) and countries involved in experimentation may partially account for some
portion of these results. It appears that placebo effects are becoming more elusive and out of control.
The Relationship Between Vitamin D Deficiency and Insulin Resistance in Pregnant Women with Gestational Diabetes
Authors: Khorasani Zahra Mazloum , Bonakdaran Shokoufeh , Rafieie Hasan Pour
Published: November 2018

Background:

Diabetes Mellitus is one of the most common medical disorders in pregnancy.
The possibility of vitamin D deficiency as a pathogenesis for impaired glucose tolerance tests show a
probable role of vitamin D in insulin secretion and reduction of insulin resistance. This study was assigned
to evaluate relation between serum vitamin D level and insulin resistance in Gestational Diabetes
Mellitus (GDM).

Methods:

This cross sectional study was done throughout one year between 2015-2016 in GDM patients
(age, 20-40 years). After history taking and physical examination, the laboratory tests including :
Fasting Blood Sugar (FBS), Glucose Tolerance Test (GTT), calcium, phosphorous, parathormone,
25(OH) vitamin D, insulin, HbA1C, TG, LDL, HDL were performed for all patients. Insulin resistance
was calculated according to HOMA-IR formula. Vitamin D level was compared between patients with
and without insulin resistance.

Results:

This research was performed in 93 GDM patients with average age (30.3 ± 5.6). Thirty eight
patients with insulin resistance and 55 patients without insulin resistance were detected. The prevalence
of vitamin D deficiency was 91.4% in all patients. There was no significant difference in vitamin D
levels between insulin resistant and non insulin resistant group (P-value=0.51).

:

In all variable parameters, only FBS and triglyceride level in insulin resistant group were more than non
insulin resistant group (P-value<0.05).

:

Obtained results showed not significant relationship between vitamin D deficiency and
insulin resistance in GDM patients.
Novel Small Molecule Inhibitors of Programmed Cell Death (PD)-1, and its Ligand, PD-L1 in Cancer Immunotherapy: A Review Update of Patent Literature
Authors: Kopalli Spandana R. , Kang Tae-Bong , Lee Kwang-Ho , Koppula Sushruta
Published: October 2018

Background:

In the last few decades, cancer immunotherapy has been extensively researched, and novel checkpoint signaling mechanisms involving Programmed Death (PD)-1 and PDLigand 1 (PD-L1) receptors have been targeted. The PD-1/PD-L1 binding and interaction play a critical role in the development of malignancies.

Objective:

The present review focuses on recent patents on the pharmacological and biological cancerregulating properties of PD-1/PD-L1 inhibitors involved in immunotherapeutic cancer drug development.

Methods:

Thorough patent literature search published during the last seven years, including the World Intellectual Property Organization (WIPO®), United States Patent Trademark Office (USPTO®), Espacenet®, and Google Patents, to identify PD-1/PD-L1-targeting small molecule immunomodulators.

Results:

Several small molecule PD-1/PD-L1 inhibitors were patented for regulation of tumor progression by academic and industry-associated investigators. Most of the claimed patents have been validated and confined to in vitro and in vivo mouse models limiting their entry into clinical settings. Majority of the patents are claimed by the researchers at Aurigene Ltd. (India) on novel peptidomimetic compounds. It is worth to be noted that macrocyclic compounds such as the peptides QP20, HD20, WQ20, SQ20, and CQ-22 from Bristol-Myers Squibb (BMS) Company, biaryl, and heterocyclic derivatives including 1,3-dihydroxy-phenyl compounds were efficient in regulating the PD-1/PD-L1 protein-protein binding and interaction compared to those of the approved monoclonal antibodies.

Conclusion:

PD-1/PD-L1 inhibitors show significant anti-cancer responses as stand-alone agents and in combination with other cancer therapies. More efficient experimental studies and clinical trials are necessary to evaluate the host-tumor cells’ interactions. Understanding the cancer microenvironment, and identifying specific biomarkers and X-ray crystalline structures of PD-1/PD-L1 complexes, including molecular and genomic signature studies are essential to determine the feasibility of PD-1/PD-L1 inhibitors for development into drug-like cancer immunotherapeutics.
Cyclosporine A Suppresses the Malignant Progression of Oral Squamous Cell Carcinoma in vitro
Authors: Gao Ling , Dong Jianwei , Zhang Nanyang , Le Zhanxian , Ren Wenhao , Li Shaoming , Li Fan , Song Jianzhong , Wang Qibo , Dou Zhichao , Park Soo Y. , Zhi Keqian
Published: October 2018

Background:

The Oral Squamous Cell Carcinoma (OSCC) is one of the most frequent cancer types. Failure of treatment of OSCC is potentially lethal because of local recurrence, regional lymph node metastasis, and distant metastasis. Chemotherapy plays a vital role through suppression of tumorigenesis. Cyclosporine A (CsA), an immunosuppressant drug, has been efficiently used in allograft organ transplant recipients to prevent rejection, and also has been used in a subset of patients with autoimmunity related disorders. The present study aims to investigate novel and effective chemotherapeutic drugs to overcome drug-resistance in the treatment of OSCC.

Methods:

Cells were incubated in the standard way. Cell viability was assayed using the MTT assay. Cell proliferation was determined using colony formation assay. The cell cycle assay was performed using flow cytometry. Apoptosis was assessed using fluorescence-activated cell sorting after stained by the Annexin V-fluorescein isothiocyanate (FITC). Cell migration and invasion were analyzed using wound healing assay and tranwell. The effect of COX-2, c-Myc, MMP-9, MMP-2, and NFATc1 protein expression was determined using Western blot analysis while NFATc1 mRNA expression was determined by RT-PCR.

Results:

In vitro studies indicated that CsA inhibited partial OSCC growth by inducing cell cycle arrest, apoptosis, and the migration and invasion of OSCC cells. We also demonstrated that CsA could inhibit the expression of NFATc1 and its downstream genes COX-2, c-Myc, MMP-9, and MMP-2 in OSCC cells. Furthermore, we analyzed the expression of NFATc1 in head and neck cancer through the Oncomine database. The data was consistent with the experimental findings.

Conclusion:

The present study initially demonstrated that CsA could inhibit the progression of OSCC cells and can mediate the signal molecules of NFATc1 signaling pathway, which has strong relationship with cancer development. That explains us CsA has potential to explore the possibilities as a novel chemotherapeutic drug for the treatment of OSCC.
Development of an Efficient Screening System for HDAC Inhibitor Based on TCF Response Element
Authors: Pang Chen , Dai Limeng , He Gang , Lu You , Zhang Bo
Published: October 2018

Background:

Acetylation of core histones is governed by opposing actions of a variety of histone
acetyltransferases (HATs) and Histone Deacetylases (HDACs). Deregulation of histone acetylation has been
causally linked to cancer development and progression, and can be potentially reversed by drug treatments.
HDAC inhibitors (HDACis) have the anti-cancer effects such as induction of cell cycle arrest, promotion of cell
apoptosis, and inhibition of metastasis. Many of these HDACis are currently in clinical development.

Methods:

To screen for novel compound with HDACis activity, cell-based strategy has been developed in current
work. The interaction of HDACs and TCFs was determined by reporter assay, and Natural products library
(A10) was screened by our system in colon cancer cells.

Results:

Based on the interaction of HDACs and TCFs, compounds with HDACis activity could be easily
picked out from Natural products library (A10) by using this screening system. Finally, a compound Wsu-18
was preliminarily identified as a potential HDACis.

Conclusion:

These data suggest our screening system for HDACis was efficient and promising, and it is suitable
for screening other small molecular chemical libraries.
An Efficient Attribute Reduction and Fuzzy Logic Classifier for Heart Disease and Diabetes Prediction
Authors: Gadekallu Thippa R. , Gao Xiao-Z.
Published: October 2018

Introduction:

Over the past decade Heart and diabetes disease prediction are major research
works in the past decade. For prediction of the Heart and Diabetes diseases, a model using an
approach based on rough sets for reducing the attributes and for classification, fuzzy logic system is
proposed in this paper.

Methods:

The overall process of prediction is split into two main steps, 1) Using rough set theory
and hybrid firefly and BAT algorithms, feature reduction is done 2) Fuzzy logic system classifies the
disease datasets. Reduction of attributes is carried out by rough sets and Hybrid BAT and Firefly optimization
algorithm.

Results and Discussion:

Then the classification of datasets is carried out by the fuzzy system which is
based on the membership function and fuzzy rules. The experimentation is performed on several
heart disease datasets available in UCI Machine learning repository like datasets of Hungarian,
Cleveland, and Switzerland and diabetes dataset collected from a hospital in India. The experimentation
results show that the proposed prediction algorithm outperforms existing approaches by achieving
better accuracy, specificity, and sensitivity.