bluuebunny/crossref_metadata_2025 huggingface dataset:
CASE REPORT OF BILATERAL LUNGS INFILTRATES
Authors: Averyanov AV Vyacheslavovich , Chernyaev AL L'vovich , Lactionova LV Valentinovna , Nosova NV Vasil'evna , Kemezh Yu V , Urazovsky N Yu
Published: March 2018

Clinical analysis of the case report 54 years woman with the diagnosis a bilateral pneumonia is performed. At the inspection included thoracoscopic biopsy, one of forms idiopathic intersticial pneumonias – Cryptogenic organizing pneumonia (COP) is revealed. In the article problems with which clinical physicians and diagnosticians meet during conducting patients with COP are discussed.
CLINICAL TRYALS OF TOLERABILITY AND SAFETY OF LYOPHILIC «LAYFFERON»,9 000 000 IU FOR INTRAMUSCULAR SOLUTION WITH PARTICIPATION OF HEALTHY VOLUNTEERS
Authors: Ryndyuk N N , Ginko Z I , Aleynikov R P , Vasilevich I V , Kuzubov V I , Usova S V , Muhina O N , Sharypova M G , Targonskiy S I
Published: March 2018

In the article results of clinical tryal of the new drug containing interferon – Layfferon, 9000000 IUintramuscular solution in healthy volunteers are presented.Safety and tolerability of the new dosage of Layfferon was estimated on the basis of supervision over a condition of volunteers, clinical and laboratory inspection within 30 day after introduction of a preparation.As a result of test it has been established, that Layfferone a doze 9 000 000 IUt is safe and tolerated. Study results have allowed to create the instruction on application for new dosage of the drug.
THE ROLE OF MYOCARDIUM REVASCULARIZATION IN PREVENTION OF ACUTE CORONARY SYNDROME COMPLICATIONS
Authors: Medvedeva IG Gennad'evna , Falaleev VL Leonidovich
Published: March 2018

The analysis of cardiovascular pathology at the attached working population is performed. To 85 patients operative interventions on restoration of a coronary blood flow have been made. As a result within the first year of supervision work capacity has been restored at 90 % of patients. Among the survived patients who have undergone a heart attack received only conservative treatment 79 % of persons have returned to work.
HISTORICAL AND MODERN ASPECTS OF BACTERIOPHAGES APPLICATION: EXPERIENCE AND PROSPECTS
Authors: Akimkin V G , Darbeeva O S , Kolkov V F
Published: March 2018

In the article questions of history, the present condition and prospect of bacteriophages are stated. Bacteriophages are continued to use alongside with antibiotics for treatment and prevent of acuteintestinal infections, purulent-septic and other diseases. Modern treatment-and-prophylactic bacteriophages are the complex polyclonal high virulent bacterial viruses which have been specially picked up against frequent infections.Considering a problem of antibiotic resistance and also the saved up database of bacteriophages efficiency, their application for prophylaxis and treatments may be one of perspective directions
INVERSION OF ORTHOTOPIC ILEAL NEOBLADDER TO PREVENT TENSION IN ANASTOMOSIS
Authors: Perepechay V A
Published: March 2018

Orthotopic ileal neobladder is the standard alternative after cystectomy, ensuring the recovery of selfurination, a full social and psychological rehabilitation of patients. From 1993 to 2010 cystectomy were performed to 209 patients, 119 (57,0%) of which underwent orthotopic bladder reconstruction in various forms: colonic plastics – 48 (40,3%) patients, intestinal plastics – 71 (59,7%) patients. In cases when short mesentery occured, a special method for bladder reconstruction was developed. The method consists in the longitudinal, not transversal crosslinking of the tank, as in the Studer orthotopic ileal neobladder, and inverting its positioning in the pelvis maximally closer to the tank wall, and overlapping tensionfree urethroreservoir anastomosis. We operated on 21 patients using this method of bladder reconstruction. All cases with insufficient length of the mesentery were compensated by the offset technique of inverting of orthotopic ileal neobladder. Cases of leak of the tank or anastomosis were not observed. Medium capacity of neobladder after removal of urethral catheter – 110 ml., in 3 months – 350 ml, in 12 months – 490.0 ml. Maximum pressure in the tank does not exceed 40 cm water column (average 30 cm H 2O). Day retention – 94,7%, night confinement at a forced night miction – 79.0%. The proposed method of inverting orthotopic ileal neobladder can be recommended when overlapping of orthotopic urinary reservoir is impossible or associated with leaks of the anastomosis due to the insufficient length of the mesentery using known techniques of orthotopic ileal bladder reconstruction.
ISSUES OF RESPIRATORY INFECTIONS PREVENTION IN OUTPATIENT CHILDREN
Authors: Petrov V A
Published: March 2018

The article analyzes the literature and the author's own research on prevention and treatment of influenza and ARTI primarily in outpatient children. Systematic analysis of the main domestic sources and trends in the treatment of ARTI in children showed that the gains in treatment and prevention of acute respiratory infections can hope for substantial improvement of clinical and costeffectiveness of an integrated system of prevention of ARTI in children population.
SURGICAL ASPECTS OF TREATMENT URATOSIS TOPHI
Authors: Kutin A A
Published: March 2018

The author analyzes his own experience of operative treatment of 27 patients with arthritic tophi. The conclusions about the need for surgical intervention at an early stage, before the development of complications. Operation with gout were local plastic nature and were individually depending on the size and location of tophi.
ORGANISATIONAL ASPECTS OF REHABILITATION IN THE MEDICAL-SANITARY UNIT OF THE INDUSTRIAL ENTERPRISE
Authors: Baiburin F Y , Antropov V I , Khramova E V
Published: March 2018

This article discusses the organization of the rehabilitation in a medical-sanitary unit of an industrial enterprise, using the example of the Central Medical-Sanitary Unit N 119. It also identifies the basic regulatory documents and presents main results of the rehabilitation work for enterprise's employees .
EFFICIENCY OF PLASMASORBTION IN PATIENTS WITH ENDOTHELIAL DYSFUNCTION WITH CHRONIC KIDNEY DISEASE
Authors: Fedoseev A N , Kudriakova A S , Smirnov V V , Krutova T A , Ovsiannikov K V
Published: March 2018

The influence of plasmasorbtion on vasodilatation activity of blood vessels in 85 patients with chronic kidney disease compared with therapy by inhibitors of angiothensine-converting enzyme was studied. It is proved the efficiency of plasmasorbtion on normalization of endothelinum-dependent vasodilatation in 74% patients and by lowing concentration of endothelinum-1 on 59±7,9% by the end of first month of trial. We noticed that therapy with inhibitors of angiohtensine-converting enzyme allowed to reach that level of endothelinum-1 only by the 6th month of trial. Normalization of endothelium functions can afford to decrease the level of daily proteinuria (p<0,05) and to increase the speed of glomerular filtration within 1 year by 7,6±1,5 ml/min in patients with I-II stage of chronic kidney disease and by 2,2±0,6 ml/min in patients with III-IV stage of chronic kidney disease.
HEPATOCELLULAR CARCINOMA TODAY
Authors: Semendyaeva M I , Merculov I A , Pastukhov A I , Gaydascheva E V , Lesnyak V N , Schutova O V
Published: March 2018

Hepatocellular carcinoma ( HCC ) is one of the most frequent disease among other cancer and one of the reason of mortality. There are serious opinions about increasing of HCC in the near future in connection of viral hepatitis. The diagnosis of HCC is mostly late and that is why surgical methods of treatment are inferior to others. In this article three patients with chronic liver diseases and HCC are discussed. The diagnostic algorithm is recommended and possibility of modern methods of treatment are considered.
OBTAINING AND APPLICATION PERSPECTIVESOF GENETICALLY MODIFIED PLURIPOTENT STEM CELLS
Authors: Kazachenko K Yu
Published: March 2018

This review considers genetic modelling of pluripotent stem cells, the problems of experimental studies and prospects of practical application.
ATYPICAL CLINICAL FEATURES OF HYPERTHYROIDISM. CASE STUDY
Authors: Soyustova E L
Published: March 2018

It is considered the case of severe heart failure in patient with Graves' Disease. Its special feature is the dominance of circulatory decompensation events in clinical picture.
CASE STUDY OF AMYLOIDOSIS WITH PRIMARY LESION OF THE HEART
Authors: Novikova O N , Rudenko E A , Alekseeva N V , Zabozlaev F G
Published: March 2018

The article describes a rare clinical case of primary amyloidosis with heart lesion and severe hydropericardium. The patient was early considered as manifestation of ischemic chronic heart failure. The diagnostic difficulties of this case are described.
STRUCTURAL-FUNCTIONAL CHARACTERISTICS OF THE RETINA MACULAR ZONEIN PATIENTS WITH DIABETES MELLITUS 1 AND 2 TYPE WITHOUT DIABETES RETINOPATHY
Authors: Kazaryan A A , Ovsepyan T R , Shishkin M M
Published: March 2018

The results of morphological and functional research of macular zone of the retina in patients with diabetes mellitus (DM) and without diabetic retinopathy (DR) are presented. Analysis of tomographic and retinographic parameters revealed decrease of thickness and damage of functional activity of the macular zone.
LAPAROSCOPIC LIVER RESECTION (literature review)
Authors: Aleksanyan G B
Published: March 2018

Laparoscopic in comparison to open surgery reduces surgical trauma, the inflammatory response and infectious complications and minimizes immunosuppression. Large sizes of tumors, biliary or vascular reconstruction are the only obstacles to the widespread use of laparoscopic liver resections. Numerous clinical studies have demonstrated a significant reduction in postoperative pain, hospital length of stay, postoperative morbidity and recovery times.
MORPHOMETRIC ASSESSMENT FOR THE PROGNOSIS OF CURRENT IN APLASTIC ANEMIA PATIENTS AFTER SPLENECTOMY
Authors: Fedorovskaya N S , Diakonov D A , Fedorovskaya N A , Pankov V N
Published: March 2018

The article presents the method of definition of the forecast of current in aplastic anemia patients after splenectomy, based on morphometric analysis of functional zones of a spleen in histologic cuts at painting by hematoxylin and eosine. At an estimation of a preparation in a light microscope by means of the computer program calculated the average area of a white pulp, further calculated its weight. Reduction in weight of a white pulp of a spleen below 10,0 g testifies to the favorable forecast of current aplastic anemia, increase - more than 10,0 g specifies adverse current of disease. This method is allows to solve differently the indications for immunosuppressive treatment of patients with given pathology after splenectomy.
MODERN POLICY OF CANCER IN PREGNANCY TO OVERCOME A HARDSHIP
Authors: Kedrova A G , Levakov S A
Published: March 2018

The natural tissue remodeling that occurs in reproductive organs of women following pregnancy and lactation promotes cancer progression, accounting for 'the dual effect' of pregnancy. There are the tumor promoting activity of physiologic regression is due to an inflammation-like microenvironment that is present during reproductive organs regression. The hypothesis that hormone-stroma from an actively involuting reproductive organs promotes tumor progression is being evaluated using both in vivo and in vitro model systems. ECM proteins that activate tumor cells invasion are being identified using proteomic approaches. We have carried out our analysis of 16 patients with pregnancy-associated cancer. The most common cases of cancer were: cervical cancer, breast cancer, ovarian cancer and lymphoproliferative disorders. In each case, the decision about the tactics of pregnancy and treatment of cancer were taken individually together with oncologists, obstetricians, pediatricians and patients. The difficulties for the adoption of an optimal solution can be attributed insufficient evidentiary basis for tactical decisions, which are often the main cause of health in favor of abortion, although the woman, in almost all cases was strongly tuned to its prolongation. Our analysis also showed a low awareness of physicians about this issue, the need for its wider discussion, both among health professionals and women who have to get up on the pregnancy as soon as possible and be tested in compliance with the principles of oncological alertness.
THE MECHANISMS AND CAUSES OF SUDDEN CARDIAC DEATH.FACTORS AND RISK STRATIFICATION IN CLINICAL PRACTICE. DEFINITIONS AND TERMS
Authors: Ardashev A V , Arutyunov G P , Zhelyakov E G , Belenkov Yu N
Published: March 2018

Cardiovascular mortality in Russia is one of the highest in the world and is 1462 deaths per 100,000 per year. The main mechanisms dramatic outcomes of cardiovascular disease are death due to heart failure and sudden cardiac death (SCD). According to the calculated data 200,000-250,000 patients died suddenly in Russia per year.The problem of the SCD is one of the urgent problems of healthcare because prevalence of it is growing up and there is obvious possibility of effective preventive measures.In the present article presents definitions associated with SCD, mechanisms, primary and secondary risk factors for SCD.
APPLICATION OF STANDARDS OF RENDERING MEDICAL CARE IN VERSATILE HOSPITAL
Authors: Nikonova E V , Afonina N S
Published: March 2018

The article highlights the practical application of medical care standards in Healthcare system in Russian Federation and determines it as an actual one. Nowadays Healthcare system in Russian Federation is not fully ready to execute in practice due to the following reasons: absence of direct criteria in medical help standards, lack of economic, financial and legislative background in clinical practice.
ILIZAROV FRAME FOR FINAL TREATMENT OF SEVERE ANKLE FRACTURES
Authors: Artem'ev A A , Zagorodnij N V , Ivashkin A N , Abakirov M D , Pletnev V V
Published: March 2018

This article is about treatment of severe ankle injuries.Significant incidence of fractures of this localization and the problem of treatment of severe soft tissue damages make the work relevant. Despite advantages of internal fixation external osteosynthesis is often the only possible solution to a severe clinical situation.A significant number of patients justify rationale for the Ilizarov frame as the primary method of treatment. The most common technical problems and complications in the treatment of fractures the optimal starting date of treatment are analyzed. The criteria of satisfactory and unsatisfactory reduction, indications to a change of fixation for internal one are described. On clinical cases the authors show good results and alternative assembles of external devices.A feature of the work is its practical value and authors’ recommendations.
OSTEOSYNTHESIS OF CLAVICLE AFTER FRACTURE AND FRACTURE-DISLOCATION
Authors: Grishanin O B , Sergeev S V , Gil'fanov S I , Abdulkhabirov M A , Agzamov D S
Published: March 2018

The problem of damage of clavicle and its ligamentous apparatus remains relevant because of the high frequency of these lesions, especially in young and active patients. Despite advances in science technology is a high frequency of unsatisfactory results. Authors, on the large clinical material, have analyzed the results of treatment of dislocations and fractures of the clavicle.Together with the national scientific production company «DEOST» the authors have developed and introduced into clinical practice new anatomically curved clavicular plate with monolithic middle part and cortical screws with low profile heads for osteosynthesis of the clavicle. Based on the analysis of 132 patients` treatment results, the authors concluded that osteosynthesis with curved plate, intramedullary pin Roskwood and hook plate for LCP clavicle gives the best results in complex fractures and fracture-dislocation of the clavicle.
TWO-STEP SURGICAL CORRECTION OF IDIOPATIC SCOLIOSIS 3-4 OF GRADE
Authors: Agzamov D S , Sampiev M T , Laka A A , Shevchenko A A , Balashov S P , Karimov R F
Published: March 2018

We report the results of two-step surgical correction of 75 patients with scoliotic deformation of vertebral columns. The first step is surgical correction by expanding endocorrector. In the second step expanding endocorrector replaced by stable screwed system. Our method offered the possibility of primary surgical correction of scoliosis in the period of rapid growth without enbarrassing the growth of the vertebrum. Consequently, the method allowed escaping the disease progression, severe vertebral columns deformation and failure of compensation. By the second step we perform additional correction and reducing the intraoperative trauma.
EXPERIMENTAL AND THEORETICAL STUDY OF ANTIMICROBIAL PROPERTIES OF CATIONIC PHTHALOCYANINES
Authors: Kovalenko I B , Strakhovskaya M G , Kovalenko S Yu , Galochkina T V , Averyanov A V , Zlenko D V , Nesterenko A M
Published: March 2018

The article is devoted to the work of the laboratory of molecular modeling and bioinformatics of Federal Scientific and Clinical Center of FMBA of Russia. The problems of photodynamic inactivation of bacteria, examining electrostatic interaction of the cationic phthalocyanines with lipopolysaccharides - endotoxins of gram-negative bacteria, the sorption properties of heterogeneous cationic phthalocyanines against lipopolysaccharides are discussed. Computer simulation of the outer membrane of Gram-negative bacteria and phthalocyanine molecules is also discussed.
CURRENT APPROACHES FOR THE DIAGNOSIS,RISK STRATIFICATION AND INTERVENTIONAL TREATMENT OF PATIENTS WITH ACUTE CORONARY SYNDROMES WITHOUT ST-SEGMENT ELEVATION
Authors: Ardashev A V , Staferov A V , Konev A V , Afonina N S , Negrun N I , Himii O V , Chelombitko E G
Published: March 2018

This article reviews current approaches to diagnosis and determination of the individual risk of patients with acute coronary syndrome without ST-segment elevation. Guidelines for determining the choice of treatment strategy and the time slots for its implementation are discussed. We describe the technical features of the implementation of interventional treatment in this group of patients; the choice of methods of myocardial revascularization is discussed.
INSUFFICIENCY OF PROPRIOCEPTIVE CONTROL AFTER PLASTIC OF THE ACL AS THE REASONFOR KNEE RE-INJURY IN PROFESSIONAL ATHLETES
Authors: Chekeres P P , Budashkina M V , Mukhanov V V , Karpashevich A A
Published: March 2018

Considered training regimes needed to restore both muscle strength of the operated limb and the neuromuscular balance of the lower extremities; and criteria for athlete returning to professional exercises, in the absence of which the risk of re-traumatisation of the knee joint is extremely high. The clinical example is given.
URETEROCELE, IN COMBINATION WITH UROLITHIASIS: CLINIC, DIAGNOSTICS AND TREATMENT
Authors: Shirshov V N , Êonstantinova I M , Shatirishvili O Ê , Doronchuk D N , Obolonkov V Yu , Lebedev Yu I
Published: March 2018

The article describes the main aspects of clinical manifestations, diagnosis and treatment of ureterocele in conjunction with urolithiasis with a sample of clinical case.
CLINICAL AND MORPHOLOGICAL OBSERVATION OF GIANT LEIOMYOMA AND UTERINE TUMORS OF CAHALE-LIKE CELLS
Authors: Askolskaya S I , Shablovsky O R , Zabozlaev F G , Popov Yu V , Kedrova A G , Radchenko N A , Kogan E A
Published: March 2018

Tumors of the myometrium, reminiscent of leiomyoma with atypical location and aggressive growth, represent a diagnostic problem due to their common manifestations in various imaging techniques. These include various types of uterine leiomyomas, stromal endometrial tumors and rare tumors of cahal-like cells.
EXPERIENCE OF THE PROCEDURE ADVANCED REAL-TIME AND SHEAR WAVES SPLEEN ELASTOGRAPHYIN MULTIDISCIPLINARY HOSPITAL
Authors: Kovalev A V , Borsukov A V , Pleshkov V G
Published: March 2018

64 patients were examined to improve technique of shear wave and real-time elastography. There were 11 patients with hematologic diseases, 19 - with infectious diseases, 24 patients with gastroenterological pathology and 10 patients with cardiologic diseases, with primary results of spleen stiffness indicators. According to the results of the studies have been made conclusions about improvement the reproducibility and efficiency of research using advanced techniques. The sensitivity amounted to 93,1%, specificity - to 89,3% and precision - 91,3%, while by using the routine method these indices amounted to 68,2%, 91,4% and 79,4% accordingly.
FROM IDIOPATHIC FIBROSING ALVEOLITIS TO IDIOPATIC LUNGS FIBROSIS
Authors: Averyanov A V
Published: March 2018

In this paper we try to present the current state of knowledge of the diagnosis and treatment of idiopathic pulmonary fibrosis (IPF), and to express our view on the problems and their solution, without which it is very difficult to improve the quality of medical care for IPF-patients in Russia.
NEW APPROACHES IN THE TREATMENT OF ACUTE INFLAMMATION OF THE EPITHELIAL PILONIDAL SINUS
Authors: Gigin N K , Chernyi N I , Ivanov Yu V
Published: March 2018

Presents an overview of russian and foreign publications, devoted to contemporary methods of conservative and surgical treatment of acute inflammation of the epithelial pilonidal sinus. Details of surgical interventions, techniques, indications and contraindications. Special attention is paid to pre-operative preparation for surgery, wound closure after surgical access, patient management in the postoperative period.
PERSONALIZED MEDICINE: FROM SCIENCE TO PRACTICE
Authors: Nikitin A G
Published: March 2018

In 2012, in Federal research and clinical centre of FMBA of Russia the laboratory of genetics was established, which conducts scientific research in the field of genetic predisposition to socially significant diseases, early diagnosis of oncopathology, as well as methods for processing genomic data. Significant experience in molecular genetic testing have allowed to help to implement a routine practice of a multiprofile hospital modern methods of genetic analysis that were previously available only to large specialized centers.
9-YEAR EXPERIENCE OF LARGE JOINTS ARTHROPLASTY
Authors: Chesnikov S G , Timoshenko M E , Dediaev S I , Rosenberg D V
Published: March 2018

Experience of small trauma and orthopedic Department shows the high efficiency of modern orthopedic technologies in major joint replacement. The application of the concept of FTS significantly reduces the cost of treatment and allows to accelerate the rehabilitation of patients.
THE FIRST EXPERIENCE OF PULMONARY VEINS CRYOABLATION IN THE TREATMENT OF ATRIAL FIBRILLATION
Authors: Sklyarov F V , Zholkovsky A V , Sumsky M A , Kornienko A A , Pleskachev A S , Borondgiyan T S , Chudinov G V
Published: March 2018

The review of domestic and foreign literary sources and own experience of cryoballon ablation, the modern method of treatment of patients with AF is presented. The indications are detailed, the data on the effectiveness and safety of the technique are given. Particular attention is paid to comparing the cryoballoon and radiofrequency isolation of the pulmonary veins.
INNOVATIVE APPROACHES TO REHABILITATION OF PATIENTS AFTER ISCHEMIC HEMISPHERIC STROkE
Authors: Ekusheva E V , Kiparisova Elena Sergeevna , Shirshova E V
Published: March 2018

Our aim was to study efficacy of pathogenetically substantiated rehabilitation of sensorimotor disorders in patients after ischemic stroke. Methods. A total of 119 patients were studied all with hemiparesis following ishemic stroke. There were 35 controls. All patients underwent rehabilitation which included robotized mechanotherapy, stabilography, neuro-muscular stimulation, physical therapy, ergotherapy, massage etc. Before and after the rehabilitation therapy TMS and SSEP parameters were evaluated in all patients. Results. Rehabilitation with the use of a personified, pathogenetically grounded approach contributed to a better recovery of the neurological deficit. In those patients who received personalized therapy significant changes of TMS parameters (central motor conduction time at rest and in facilitation probe), but not SSEP ones were registered. Conclusions. The effectiveness of the pathogenetically substantiated rehabilitation of patients after ischemic stroke was demonstrated. Were demonstrated more effective in restorative treatment of motor deficits. Somatosensory functions were restored worse, which implies the identification and takes into the account of the sensory deficit, as well as neurophysiological monitoring of the recovery process with the use of TMS and SSEP to improve the effectiveness of ongoing rehabilitation in this category of patients.
COMPLICATIONS OF CERVICAL SPINE SURGERY. RISK FACTORS AND PREVENTIVE STRATEGIES
Authors: Grin A A , Kasatkin D S
Published: March 2018

According to numerous studies, the percentage of complications after operations on the cervical spine is up to 27.0%, the number of patients requiring re-intervention - to 10.7%. Postoperative mortality is 0.26% [1-10]. The identification and study of the effect of the most important risk factors and their combinations on the frequency and severity of postoperative complications, an analysis of the causes of errors made during surgery or at the stage of planning, and the formation of a unified approach to solving the problem of timely diagnosis, treatment and prevention will reduce the number of complications and improve the quality of surgical treatment of patients with diseases and trauma of the cervical spine on subaxial level.
AGE PECULIARITIES OF COMORBID PATHOLOGY IN PATIENTS UNDERGOING PLANNED CORONARY ARTERYBYPASS GRAFTING
Authors: Barbarash O L , Zhidkova I I , Shibanova I A , Ivanov S V , Sumin A N , Samorodskaya I V
Published: March 2018

Background: The number of elderly patients undergoing coronary artery bypass grafting (CABG) is increasing worldwide. Therefore, the assessment of comorbidities based on the age factor in patients with coronary artery disease (CAD) is highly relevant.Aim: To assess the associations between the age factor and comorbidities in patients undergoing CABG. Material and Methods: Data of 680 patients [538 (79.10%) men and 142 (20.90%) women], undergoing elective CABG in the period 2011-2012, included in the CABG Registry were used to detect comorbidities.All patients were enrolled into 4 age groups: below 50 years, 51-60 years, 61-70 years, over 70 years.Results: Aging was associated with an increase in the proportion of women suffering from arterial hypertension (AH), and multivessel disease. Similarly, the proportion of patients with higher func-tional class (FC) of angina, heart failure (CH), and heart rhythm disturbances increased. The number of patients referred to elective CABG with previous myocardial infarction (MI) was the highest among young adults (77%). Aging was associated with an increase in the number of patients with chronic pyelonephritis (44.30%) and thyroid pathology (3.40%).Conclusion: Patients’ aging is associated with an increase in cardiovascular comorbidities, but not MI. Importantly, there was no any increase in the rate of non-cardiovascular comorbidities.
NUTRIOGENETIC TEST IN CLINICAL PRACTICE: GOALS AND OPPORTUNITIES
Authors: Zelenskaya E M , Kokh N V , Slepukhina A A , Lifshits G I
Published: March 2018

Nutgenogenetics is the science of the influence of genetically determined differences on the assimilation of nutrients and their metabolism. The goal of nutrigenetics is to create an individual diet that will allow to optimize health status and prevent deseases. This test assesses the genetic contribution to the individual effectiveness of low-fat, low-carb diets and various types of sport exercises in order to reduce body weight. In the presence of some genetically determined conditions (Gilbert’s syndrome, hemochromatosis) - there is a need to follow a certain diet for the prevention of complications. A relative risk of insulin resistance and dyslipidemia, features of eating behavior can also be determined.
An Overview of Scientific-Based Knowledge on Sedentary Behaviour Among the Pediatric Population - A Conceptual Model Development
Authors: Aubert Salomé
Published: March 2018

Sedentary behaviour has been identified as a specifically deleterious personal practice on multiple levels of health of individuals at all ages, including the pediatric population (i.e., 0 to 18 years of age). The aims of this paper are to (i) summarize the literature con-cerning the definition, the characteristics, the context, the determinants, and the conse-quences of sedentary behaviour among children and youth; (ii) propose a conceptual model that summarizes these findings; and (iii) highlight research gaps in the literature. Sedentary behaviours are common and complex behaviours that can potentially affect the health of children and youth on the physiological and psychological levels. Those deleterious effects on health can vary depending on how they are accumulated through-out the day, for example with or without interruption, or in which context. While child-hood engagement in sedentary behaviours is too high in the majority of countries where it has been assessed, developing research and policies that target the reduction of seden-tary behaviours among children and youth must be ranked as a top priority for all public health organizations worldwide. Although further research is needed concerning the identification of the specific determinants and consequences of different types and pat-terns of sedentary behaviours in various contexts, the Conceptual Model for the Study and Understanding of Children and Youth’s Sedentary Behaviour, gives an overview of the topic and supports the development of policy and further research.
The Global Burden of Surgical Disease: An Analysis on Inaccessible Surgical Care in Low and Middle Income Countries
Authors: Huynh Chau , Huynh Minh NQ
Published: March 2018

Worldwide, 4.8 billion people do not have access to safe, adequate surgical care and anaesthetic management. Surgical care has been deemed “the neglected child of global health,” a startling reminder of the disparities in health services. The provision of surgical interventions can avert 11% of the global burden of disease and 1.5 million deaths each year. Many obstacles exist for low- and middle-income countries (LMIC) to progress towards accessible surgical care. The first challenge is delivering cost-effective surgical care despite financial constraints and political turmoil. Foreign aid was established to alleviate the financial burden and its contributions have been pivotal. However, based on the political climate in certain countries, funds are siphoned to government sectors other than health care. Moreover, the lack of infrastructure, equipment, and personnel in LMIC compound the issue. The other challenge is determining if surgery is as feasible and effective as non-surgical health interventions. Surgical care is crucial and this paper aims to assess the challenges that limit its stature in global health discussions. The paper will address the influence of financing, infrastructure, workforce, service delivery, and information management on surgical care, and the current resolutions, such as humanitarian aid missions.
Clinical profile and outcome of neonates admitted during summer months with dehydration and hypernatremia in tertiary care hospital of central Gujarat, India
Authors: Shah Rinki H. , Javadekar Bakul B.
Published: March 2018

Background: Dehydration and hypernatremia amongst exclusively breast fed neonates due to inadequate breast feeding or due to less feeding is a potentially devastating condition, and its incidence rate increases during hot environment especially during summer months. We conducted this study to identify possible etiology behind dehydration and hypernatremia among healthy newborn.Methods: Authors retrospectively studied from available records from our Extramural NICU for months of March, April, and May 2017. Inclusion criteria for study were 1) Neonates with signs and symptoms of dehydration, 2) exclusively breast fed newborn. Those with congenital malformations, very low birth weight and perinatal asphyxia were excluded from the study.Results: Total NICU admissions were 434 during these months, and 28 patients we received with dehydration and 21 patients out of 28 had hypernatremia. Incidence rate of dehydration was 6.45%. Almost all the patients had altered renal functions at the time of admission, which became normal before discharge. 4 patients had culture proven sepsis. 2 patients died out of 28 patients. 26 patients out of 28 recovered completely and discharged.Conclusions: Dehydration and hypernatremia is preventable and treatable condition. All the mothers needs to taught correct feeding method like proper position and attachment of feeding. Signs of dehydration must be explained to mother as well as close relatives. Follow up visits should be ensured and check for weight is must. Not to encourage mother to give any other feed apart from exclusive breast feeding for first 6 months and even during summer months.
The Effect of Retaining Bonuses on Delaying Early Retirement – Financial Incentives Revisited
Authors: Hermansen Åsmund , Midtsundstad Tove
Published: March 2018

In this paper, we analyze the effect of the retaining bonus on early retirement behavior using a unique dataset consisting of a Norwegian employer survey from 2010 combined with register data on all older employees in the period 2000–2010. The retaining bonus is one of the most common retention measures offered by Norwegian companies to prevent their older workers from retiring early. The most common arrangement is a lump sum of between 10,000 and 25,000 Norwegian Kroner (between 1100 and 2600 Euros), which was less than the mean monthly pay before tax in Norway in 2010. In spite of this modest sum, our analysis shows that retaining bonuses of 20,000 NOK or more do reduce the probability of 61-year-olds retiring in the next two years of employment
TEMPO E EDUCAÇÃO: REFLEXÕES SOBRE FRANÇA E ALEMANHA
Authors: Venco Selma Borghi
Published: March 2018

Este artigo tem como objetivo analisar as características da política educacional em dois países: Alemanha e França, particularmente no que concerne ao tempo de permanência nas escolas. A pesquisa, de caráter documental e bibliográfico, privilegiou as informações oriundas da OCDE sobre a política educacional nos países participantes do PISA, bem como as disponibilizadas pela Comunidade Europeia. O tempo, enquanto categoria analítica, é aqui compreendido sociologicamente como uma construção social, a qual se inscreve no advento do capitalismo, e passa a determinar ritmos e processos, inclusive no âmbito da vida privada. Constatou-se que a França mantém sólida tradição nas escolas de tempo integral, cuja permanência dos estudantes na educação básica atrela-se ao currículo, e ao ensino aprofundado de um segundo idioma. A Alemanha, por sua vez, adere paulatinamente a tal política, como resposta aos resultados negativos apresentados no PISA em 2000; contudo, privilegia o contraturno às aulas de reforço e recuperação e não como forma de complementação curricular.

Palavras-chave: Escola de Tempo Integral. Norma Temporal. Política Educacional; tempo e educação.
The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease
Authors: Zinöcker Marit K. , Lindseth Inge A.
Published: March 2018

The dietary pattern that characterizes the Western diet is strongly associated with obesity and related metabolic diseases, but biological mechanisms supporting these associations remain largely unknown. We argue that the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome. The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease. Recognizing the importance of the microbiome in the development of diet-related disease has implications for future research, public dietary advice as well as food production practices. Research into food patterns suggests that whole foods are a common denominator of diets associated with a low level of diet-related disease. Hence, by studying how ultra-processing changes the properties of whole foods and how these foods affect the gut microbiome, more useful dietary guidelines can be made. Innovations in food production should be focusing on enabling health in the super-organism of man and microbe, and stronger regulation of potentially hazardous components of food products is warranted.
Using a Counting Process Method to Impute Censored Follow-up Time Data
Authors: Efird Jimmy T. , Jindal Charulata
Published: March 2018

Censoring occurs when complete follow-up time information is unavailable for patients enrolled in a clinical study. The process is considered to be informative (nonignorable) if the likelihood function for the censoring model cannot be partitioned into a set of response parameters that are independent of the censoring parameters. In such cases, estimated survival time probabilities may be biased, prompting the need for special statistical methods to remedy the situation. The problem is especially salient when censoring is skewed toward the early phase of a study. In this paper, we describe a method to impute censored follow-up times using a counting process method.
Weekdays and Weekends Variation of Step Count in 9 to 11 Years Old Obese School Children
Authors: Wafa Sharifah Wajihah , Aziz Nur Nadzirah , Rahim Marhasiyah
Published: March 2018

A major health threat for children in the 21st century is physical inactivity in conjunction with the elevated prevalence of obesity. In Malaysia, low physical activity among children is a major concern. The objective of the study was to analyze the day to day variation of step count in a sample of obese children using the activPALTM monitor. This was a cross sectional study conducted in Kuala Terengganu, Terengganu. The sample compromised 41 boys and 24 girls between the ages of 9-11 years. Number of steps was objectively measured using an activPALTM accelerometer over a period of 4-7 days and had their height and weight measured. Mean step count from this sample of obese children was 8861 ± 3157steps. Steps per day were significantly higher for boys compared to girls (p=0.034). Obese children took significantly more steps at weekdays than on weekends (p=0.001). Steps/hour were significantly higher in weekday compared to weekend between 0600 to 0700 (p<0.001), 0700 to 0800 (p<0.001), 0800 to 0900 am (p<0.001), 0900 to 1000 (p=0.032), 1000 to 1100 (p=0.046), 1100 to 1200 (p<0.001), 1300 to 1400 (p=0.002), 1400 to 1500 (p<0.001), 1800 to 1900 (p=0.026) and 2000 to 2100 (p=0.019). Detailed daily patterns of physical activity are required to fully understand the differences across days that help future interventions to target those falling short particularly during weekend.
Buckwheat and CVD Risk Markers, a Systematic Review and Meta-Analysis
Authors: Li Liangkui , Lietz Georg , Seal Chris J.
Published: March 2018

The effects of buckwheat intake on cardiovascular diseases (CVD) have not been systematically investigated. The aim of the present study was to comprehensively summarise studies in humans and animals evaluating the impact of buckwheat consumption on CVD risk markers and to conduct a meta-analysis of relevant data. Thirteen randomised, controlled human studies, two cross-sectional human studies and twenty-one animal studies were identified. Using random effects models, the weighted mean difference of post-intervention concentrations of blood glucose, total cholesterol and triglycerides were significantly decreased following buckwheat intervention compared with controls [differences in blood glucose: -0.85 mmol/L (95% CI: -1.31, -0.39), total cholesterol: 0.50 mmol/L (95% CI: -0.80, -0.20) and triglycerides: 0.25 mmol/L (95% CI: -0.49, -0.02)]. Responses of a similar magnitude were seen in two cross-sectional studies. For animal studies, nineteen of twenty-one studies showed a significant reduction in total cholesterol of between 12 and 54%, and fourteen of twenty studies showed a significant reduction in triglycerides of between 2 and 74%. All exhibited high unexplained heterogeneity. There was inconsistency in HDL cholesterol outcomes in both human and animal studies. It remains unclear whether increased buckwheat intake significantly benefits other markers of CVD risk, such as weight, blood pressure, insulin, and LDL-cholesterol, and underlying mechanisms responsible for any effects are unclear.
Maximum Power Point Tracking for Brushless DC Motor Driven Photovoltaic Pumping System Using Hybrid ANFIS-FLOWER Pollination Optimization Algorithm
Authors: Priyadarshi Neeraj , Padmanaban Sanjeevikumar , Mihet-Popa Lucian , Blaabjerg Frede , Azam Farooque
Published: March 2018

In this research paper, a hybrid Artificial Neural Network (ANN)-Fuzzy Logic Control (FLC) tuned Flower Pollination Algorithm (FPA) as a Maximum Power Point Tracker (MPPT) is employed to emend root mean square error (RMSE) of photovoltaic (PV) modeling. Moreover, Gaussian membership functions have been considered for fuzzy controller design. This paper interprets Luo converter occupied brushless DC motor (BLDC) directed PV water pump application. Experimental responses certify the effectiveness of the suggested motor-pump system supporting diverse operating states. Luo converter is newly developed dc-dc converter has high power density, better voltage gain transfer and superior output waveform and able to track optimal power from PV modules. For BLDC speed controlling there is no extra circuitry and phase current sensors are enforced for this scheme. The recentness of this attempt is adaptive neuro-fuzzy inference system (ANFIS)-FPA operated BLDC directed PV pump with advanced Luo converter has not been formerly conferred.
Controle de bacterias psicrotróficas e Escherichia coli em linguiça de peixe tipo frescal adicionada de óleo essencial de orégano
Authors: EVANGELISTA-BARRETO Norma Suely , COSTA JÚNIOR Paulo Sérgio Pedroso , VIEIRA Brenda Borges
Published: March 2018

O objetivo deste trabalho foi elaborar linguiça de peixe frescal adicionada de óleo essencial de orégano como conservante natural. Para isso foi determinado o valor da Concentração Inibitória Mí­­nima (CIM) do óleo essencial de orégano frente a seis patógenos de interesse alimentar. A atividade antimicrobiana do óleo de orégano (0,08 e 0,16%) na linguiça de peixe mantida sob refrigeração foi verificada por meio da contagem de bactérias psicotróficas cultiváveis (BPC) durante 20 dias e após contaminação intencional com Escherichia coli (72 h). O óleo essencial de orégano apresentou forte atividade antibacteriana (CIM 50-800 Î¼g mL-1), com ação bactericida (CIB 1600 Î¼g mL-1). A linguiça de peixe frescal adicionada do óleo de orégano (0,08%) inibiu o desenvolvimento de E. coli no sistema alimentar, enquanto a concentração de 0,16% do óleo de orégano se mostrou mais efetivo no controle de BPC. O óleo essencial de orégano pode ser usado como barreira adicional em alimentos para o desenvolvimento de bactérias deteriorantes e E. coli.
Óleo essencial de Aloysia triphylla é efetivo no transporte de tilápia do Nilo
Authors: TEIXEIRA Rafael Rivas , SOUZA Renilde Cordeiro de , SENA Artur Cedraz , BALDISSEROTTO Bernardo , HEINZMANN Berta Maria , COPATTI Carlos Eduardo
Published: March 2018

Este estudo avaliou o uso do óleo essencial de Aloysia triphylla (OEAT) como redutor de estresse no transporte de tilápia do Nilo, Oreochromis niloticus. Juvenis foram transportados em carro por 8 h em sacos plásticos contendo água com 0 (controle), 20 ou 30 Î¼L L-1 OEAT (em triplicata). Nós avaliamos qualidade da água, fluxos iônicos (ClâË†"™, Na+ e K+), parí­¢metros plasmáticos (cortisol, glicose, lactato e paraoxonase) e taxa de ventilação (TV) de tilápia do Nilo. Nenhuma mortalidade ocorreu durante o transporte. Juvenis de tilápia do Nilo transportados com 20 ou 30 Î¼L L-1 OEAT apresentaram menor pH da água do que o grupo controle e com 30 Î¼L L-1 OEAT apresentaram menor condutividade, alcalinidade e fluxos de ClâË†"™, Na+ e K+ da água comparado aos demais tratamentos. O OEAT não alterou ní­­veis de cortisol e paraoxonase do plasma, mas reduziu TV, e 30 Î¼L L-1 OEAT reduziu os ní­­veis de glicose plasmática comparada ao grupo controle depois do transporte. O uso de 20 Î¼L L-1 OEAT aumentou os ní­­veis plasmáticos de lactato comparado aos demais tratamentos. O uso de 30 Î¼L L-1 OEAT para sedação em transporte de 8 h de tilápia do Nilo é recomendado por melhorar qualidade de água e reduzir perdas iônicas, ní­­veis plasmáticos de glicose e TV.
Clinostomum sp. (Digenea: Clinostomidae) e Ascocotyle sp. (Digenea: Heterophyidae): metacercárias com potencial zoonótico em peixes da bacia do Rio Tramandaí­­, sul do Brasil
Authors: POZZA Alice , LIMA Fábio , HAAS Mateus Luís , LEHMANN ALBORNOZ Pablo Cesar
Published: March 2018

Os helmintos pertencentes í­Â  Classe Trematoda têm grande importí­¢ncia na ictioparasitologia, onde a Subclasse Digenea apresenta parasitos com potencial zoonótico. A famí­­lia Heterophyidae é responsável pela heterofidí­­ase e no Brasil essa doença é causada por trematódeos do gênero Ascocotyle (Phagicola), comumente conhecida como fagicolose, transmitida de peixes í­Â s aves e mamí­­feros. Já as larvas de Clinostomum, presentes na musculatura de peixes, tem aves piscí­­voras como seus hospedeiros definitivos, e podem parasitar seres humanos acidentalmente, causando laringofaringite parasitária e morte por asfixia. Este estudo busca quantificar a presença de parasitos digenéticos das famí­­lias Heterophyidae e Clinostomidae com potencial zoonótico em peixes da bacia do rio Tramandaí­­/RS. Os peixes foram adquiridos de pescadores do municí­­pio de Terra de Areia/RS, entre julho de 2016 e maio de 2017 e necropsiados í­Â  procura de parasitas. Os digenéticos foram fixados, corados e montados em lí­¢minas para identificação. Índices parasitológicos foram calculados. Astyanax spp. foram positivos para Ascocotyle enquanto Geophagus brasiliensis apresentou-se infectado por Clinostomum sp. Sendo assim, os resultados obtidos sugerem risco de infecção para a população regional consumidora.
A Modification of MOEA/D for Solving Multi-Objective Optimization Problems
Authors: Zheng Wei , Tan Yanyan , Gao Meng , Jia Wenzhen , Wang Qiang ,   School of Information Science and Engineering, Shandong Normal University No. 1, University Road, Changqing District, Jinan 250358, China,   Institute of Data Science and Technology, Shandong Normal University Jinan, Shandong 250358, China
Published: March 2018

In this paper, a novel modified algorithm based on MOEA/D, abbreviated as mMOEA/D, is proposed for well solving the multi-objective optimization problems. Our proposed mMOEA/D inherits from MOEA/D. In mMOEA/D, a novel elastic weight vectors design method is introduced and adopted to make those weight vectors spread more widely. On the other hand, a flexible and efficient trail DE operator is designed and used in mMOEA/D for further enhancing the performance of MOEA/D. Three groups of experimental studies are carried out. Proposed mMOEA/D is compared with the four state-the-art multi-objective optimization evolutionary algorithms on solving the multi-objective optimization problems with many objectives, and the other is that mMOEA/D is compared with MOEA/D-DE, an improved version of MOEA/D, on solving the multi-objective optimization problems with complicated PS shapes. The versions of mMOEA/D with the improvement of weight vector and DE operator are compared with MOEA/D-DE to solve multi-objective optimization problems at last. The experimental results show that mMOEA/D performs the best on almost all test instances. In other words, our proposed modification of MOEA/D is effective.