bluuebunny/crossref_metadata_2025 huggingface dataset:
Mortality among hospitalized COVID-19 patients during surges of SARS-CoV-2 alpha (B.1.1.7) and delta (B.1.617.2) variants
Authors: Zali Alireza , Khodadoost Mahmood , Gholamzadeh Saeid , Janbazi Shahriar , Piri Hassan , Taraghikhah Nazanin , Hannani Khatereh , Looha Mehdi Azizmohammad , Mohammadi Gohar
Published: November 2022

The aim of this study was to evaluate the death proportion and death risk of COVID-19 hospitalized patients over time and in different surges of COVID-19. This multi-center observational study was conducted from March 21, 2021 to October 3, 2021 which included the alpha and delta SARS-CoV-2 surges occurred in April and August in Tehran, respectively. The risk of COVID-19 death was compared in different months of admission. A total of 270,624 patients with COVID-19, of whom 6.9% died, were admitted to hospitals in Tehran province. Compared to patients admitted in March, a higher risk of COVID-19 death was observed among patients admitted to the hospital in July (HR 1.28; 95% CI 1.17, 1.40), August (HR 1.40; 95% CI 1.28, 1.52), September (HR 1.37; 95% CI 1.25, 1.50) and October (HR 4.63; 95% CI 2.77, 7.74). The ICU death proportion was 36.8% (95% CI: 35.5, 38.1) in alpha surge and increased significantly to 39.8 (95% CI 38.6, 41.1) in delta surge. The risk of COVID-19 death was significantly higher in delta surge compared to alpha surge (HR 1.22; 95% CI 1.17, 1.27). Delta surge was associated with a higher risk of death compared to alpha surge. High number of hospitalizations, a shortage of hospital beds, ICU spaces and medical supplies, poor nutritional status of hospitalized patients, and lack of the intensivist physicians or specialized nurses in the ICU were factors that contributed to the high mortality rate in the delta surge in Iran.
Microsatellite analysis and polymorphic marker development based on the full-length transcriptome of Camellia chekiangoleosa
Authors: Tian Qianqian , Huang Bin , Huang Jianjian , Wang Bo , Dong Le , Yin Xin , Gong Chun , Wen Qiang
Published: November 2022

Camellia chekiangoleosa is a popular variety of Oil-camellia that has high oil production and ornamental value. Microsatellite (SSR) markers are the preferred tool for the molecular marker-assisted breeding of C. chekiangoleosa. By focusing on the problems of the low development efficiency of polymorphic SSR markers and the lack of available functional markers in Oil-camellia, we identified 97,510 SSR loci based on the full-length transcriptome sequence of C. chekiangoleosa. An analysis of SSR characteristics showed that mononucleotide (51.29%) and dinucleotide (34.36%) SSRs were the main repeat types. The main SSR distribution areas based on proportion covered were ordered as follows: 5'UTR > 3'UTR > CDS. By comparing our data with those in databases such as GO and KEGG, we obtained functional annotations of unigene sequences containing SSR sites. The data showed that the amplification efficiency of the SSR primers was 51.72%, and the development efficiency of polymorphic SSR primers was 26.72%. Experiments verified that dinucleotide and pentanucleotide SSRs located in UTR regions could produce more polymorphic markers. An investigation into the genetic diversity of several C. chekiangoleosa populations also suggested that the developed SSR markers had higher levels of polymorphism. This study will provide a reference and high-quality markers for the large-scale development of functional SSR markers and genetic research in Oil-camellia.
Improvement of the signal to noise ratio for fluorescent imaging in microfluidic chips
Authors: Liu Xiaocheng , Zhu Hanliang , Sabó Ján , Lánský Zdeněk , Neužil Pavel
Published: November 2022

Microfluidics systems can be fabricated in various ways using original silicon glass systems, with easy Si processing and surface modifications for subsequent applications such as cell seeding and their study. Fluorescent imaging of cells became a standard technique for the investigation of cell behavior. Unfortunately, high sensitivity fluorescent imaging, e.g., using total internal reflection fluorescence (TIRF) microscopy, is problematic in these microfluidic systems because the uneven surfaces of the silicon channels’ bottoms affect light penetration through the optical filters. In this work, we study the nature of the phenomenon, finding that the problem can be rectified by using a silicon-on-insulator (SOI) substrate, defining the channel depth by the thickness of the top Si layer, and halting the etching at the buried SiO2 layer. Then the fluorescent background signal drops by = 5 times, corresponding to the limit of detection drop from = 0.05 mM to = 50 nM of fluorescein. We demonstrate the importance of a flat surface using TIRF-based single-molecule detection, improving the signal to a noise ratio more than 18 times compared to a conventional Si wafer. Overall, using very high-quality SOI substrates pays off, as it improves the fluorescence image quality due to the increase in signal-to-noise ratio. Concerning the cost of microfluidic device fabrication—design, mask fabrication, wafer processing, and device testing—the initial SOI wafer cost is marginal, and using it improves the system performance.
Optimization of 3D-aggregated spheroid model (3D-ASM) for selecting high efficacy drugs
Authors: Lee Sang-Yun , Hwang Hyun Ju , Lee Dong Woo
Published: November 2022

Various three-dimensional (3D) cell culture methods have been developed to implement tumor models similar to in vivo. However, the conventional 3D cell culture method has limitations such as difficulty in using an extracellular matrix (ECM), low experimental reproducibility, complex 3D cell culture protocol, and difficulty in applying to high array plates such as 96- or 384-plates. Therefore, detailed protocols related to robust 3D-aggregated spheroid model (3D-ASM) production were optimized and proposed. A specially designed wet chamber was used to implement 3D-ASM using the hepatocellular carcinoma (HCC) cell lines, and the conditions were established for the icing step to aggregate the cells in one place and optimized ECM gelation step. Immunofluorescence (IF) staining is mainly used to simultaneously analyze drug efficacy and changes in drug-target biomarkers. By applying the IF staining method to the 3D-ASM model, confocal microscopy imaging and 3D deconvolution image analysis were also successfully performed. Through a comparative study of drug response with conventional 2D-high throughput screening (HTS), the 3D-HTS showed a more comprehensive range of drug efficacy analyses for HCC cell lines and enabled selective drug efficacy analysis for the FDA-approved drug sorafenib. This suggests that increased drug resistance under 3D-HTS conditions does not reduce the analytical discrimination of drug efficacy, also drug efficacy can be analyzed more selectively compared to the conventional 2D-HTS assay. Therefore, the 3D-HTS-based drug efficacy analysis method using an automated 3D-cell spotter/scanner, 384-pillar plate/wet chamber, and the proposed 3D-ASM fabrication protocol is a very suitable platform for analyzing target drug efficacy in HCC cells.
The spread of Carpophilus truncatus is on the razor's edge between an outbreak and a pest invasion
Authors: de Benedetta Flavia , Gargiulo Simona , Miele Fortuna , Figlioli Laura , Innangi Michele , Audisio Paolo , Nugnes Francesco , Bernardo Umberto
Published: November 2022

In 2019, in southern Italy (Campania) there was an outbreak of a sap beetle infesting stored walnut fruits. A monitoring activity started to assess the spread and impact of the pest in walnut orchards and in warehouses, and an integrative characterization led to identify the beetle asCarpophilus truncatus. This species has been in Europe for a long time, rare and harmless until recently. We show also that this species is the same recently recorded in other two continents, Latin America and Australia, where it is causing massive damage on walnut and almond fruits. The sharing of a mitochondrial haplotype among populations recorded on three continents suggests that a worldwide invasion might be ongoing. A Geographic Profiling approach has determined that the more virulent population was first introduced in Italy, and the climate conditions of areas whereC. truncatusis currently widespread and harmful indicate that the entire walnuts world production is in jeopardy as this species could adapt to any of the main walnut and almond production areas.
Condensed tannins act as anthelmintics by increasing the rigidity of the nematode cuticle
Authors: Greiffer Luise , Liebau Eva , Herrmann Fabian C. , Spiegler Verena
Published: November 2022

Tannins and tanniferous plant extracts have been discussed as sustainable means for helminth control in the past two decades in response to a dramatic increase of resistances towards standard anthelmintics. While their bioactivities have been broadly investigated in vitro and in vivo, less is known about their mode of action in nematodes, apart from their protein binding properties. In the current study we therefore investigated the impact of a phytochemically well characterized plant extract from Combretum mucronatum, known to contain procyanidins as the active compounds, on the model organism Caenorhabditis elegans. By different microscopic techniques, the cuticle was identified as the main binding site for tannins, whereas underlying tissues did not seem to be affected. In addition to disruptions of the cuticle structure, molting defects occurred at all larval stages. Finally, an increased rigidity of the nematodes’ cuticle due to binding of tannins was confirmed by force spectroscopic measurements. This could be a key finding to explain several anthelmintic activities reported for tannins, especially impairment of molting or exsheathment as well as locomotion.
Cannabidiol affects breast meat volatile compounds in chickens subjected to different infection models
Authors: Konieczka Paweł , Wojtasik-Kalinowska Iwona , Poltorak Andrzej , Kinsner Misza , Szkopek Dominika , Fotschki Bartosz , Juśkiewicz Jerzy , Banach Joanna , Michalczuk Monika
Published: November 2022

No study has demonstrated the use of dietary Cannabis-derived cannabidiol (CBD) to alter the stress response in chickens or examined its effects on meat volatile compounds (VOCs). Here, we subjected chickens to dysbiosis via C. perfringens infection or Escherichia coli lipopolysaccharide (LPS) treatment and investigated the potential link between meat VOCs and cecal bacterial activity and the ameliorative effect of CBD. The cecal bacterial production of short-chain fatty acids (SCFAs) was closely correlated with meat VOCs. CBD supplementation reduced the formation of breast meat spoilage VOCs, including alcohols, trimethylamine and pentanoic acid, in the challenged birds, partly by decreasing cecal putrefactive SCFA production. Meat VOC/cecal SCFA relationships differed according to the challenge, and CBD attenuated the effects of C. perfringens infection better than the effects of LPS challenge on meat VOCs. These findings provide new insights into the interactions among bioactive agent supplementation, gut microbiota activity and meat properties in birds.
Anti-biofilm activity of caffeine against uropathogenic E. coli is mediated by curli biogenesis
Authors: Rathi Bhawna , Gupta Surbhi , Kumar Parveen , Kesarwani Veerbhan , Dhanda Rakesh Singh , Kushwaha Sandeep Kumar , Yadav Manisha
Published: November 2022

Biofilms are assemblages of sessile microorganisms that form an extracellular matrix around themselves and mediate attachment to surfaces. The major component of the extracellular matrix of UropathogenicE. coliand other Enterobacteriaceae are curli fibers, making biofilms robust and resistant to antimicrobials. It is therefore imperative to screen antibiofilm compounds that can impair biofilm formation. In the present study, we investigated the curli-dependent antibiofilm activity of caffeine against UPEC strain CFT073 and commensal strainE. coliK-12MG1655.Caffeine significantly reduced the biofilm formation of both UPEC andE. coliK-12 by 86.58% and 91.80% respectively at 48 mM caffeine as determined by Crystal Violet assay. These results were further confirmed by fluorescence microscopy and Scanning Electron Microscope (SEM). Caffeine significantly reduced the cytotoxicity and survivability of UPEC. Molecular docking analysis revealed a strong interaction between caffeine and curli regulator protein (Csg D) ofE. coli. The qRT-PCR data also showed significant downregulation in the expression of CsgBA and the CsgDEFG operon at both 24 mM and 48 mM caffeine. The findings revealed that caffeine could inhibitE. colibiofilm formation by regulating curli assembly and thus may be used as an alternative therapeutic strategy for the treatment of chronicE. colibiofilm-related infections.
A novel puncture approach via point “O” for percutaneous kyphoplasty in patients with L4 or L5 osteoporotic vertebral compression fracture
Authors: Huang Jiahu , Yang Jin , Chen Lanjing , Xu Yinzhi , Wang Song
Published: November 2022

This study introduced a novel point “O” puncture approach for percutaneous kyphoplasty (PKP) in patients with L4 or L5 osteoporotic vertebral compression fracture (OVCF) and evaluated its clinical and radiographic outcomes. Between September 2019 and December 2020, we compared the clinical and radiographic outcomes in 31 cases (36 vertebrae) using the “O” entry point PKP intervention (O-PKP) and 31 cases (37 vertebrae) using transverse the process-pedicle approach PKP intervention (T-PKP). No serious postoperative complications were observed in any of the participants. Only two T-PKP patients experienced intervertebral disc space leakage. Compared with the T-PKP patients, the O-PKP patients showed shorter operative time and fluoroscopy times (P < 0.05), comparable blood loss and cement volume (P > 0.05), improved VAS and ODI scores at the final follow-up (P < 0.05), better increases in the vertebral compression ratio (P < 0.05), comparable Cobb angle (P > 0.05), comparable anteroposterior bone cement distribution, enhanced bilateral bone cement distribution (P < 0.05), and larger sagittal and transverse angles (P < 0.05). Herein, O-PKP was indicated for patients with L4 or L5 OVCF. This puncture approach showed significant advantages over T-PKP not only in terms of pain relief, surgery and fluoroscopy times but also in the puncture angle, vertebral reconstruction, and symmetrical cement distribution.
Association of urinary prostaglandin E2 metabolite and mortality among adults
Authors: Wen Wanqing , Yang Gong , Cai Qiuyin , Shu Xiao-Ou , Zheng Wei
Published: November 2022

Prostaglandins play a critical role in inflammatory response. To investigate the association of urinary PGE-M, a stable end-product of prostaglandin E2 (PGE2) with overall and cause-specific mortality and examine potential effect modifiers, we obtained urinary PGE-M levels of 2927 non-cancerous adults from our previous case-control studies nested in the Shanghai Women’s Health Study and Shanghai Men’s Health Study, two cohort studies conducted in Shanghai, China. Mortality data and modifiable factors associated with urinary PGE-M were obtained from the parent cohort studies. Using linear regression models, we found that high urinary PGE-M levels were significantly associated with low education, heaving smoking, old age at urine collection, and abdominal obesity. Using Cox proportional hazards models, we found that increase (per standard deviation) of urinary PGE-M levels were significantly associated with overall mortality (adjusted hazard ratio = 1.19, 95% confidence interval: 1.07, 1.33) and particularly deaths from cardiometabolic diseases (adjusted hazard ratio = 1.27, 95% confidence interval: 1.11, 1.44). The increased death risks persisted across different time intervals during the follow-up and were stronger among participants who were younger than 60 (P = 0.0014 for all- cause mortality and P = 0.007 for deaths from cardiometabolic diseases) at urine collection or perhaps among those who had higher education.
Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols
Authors: Luo Yuze , Wang Zefeng , Li Junqin , Yi Wenhua , Yang Ke , Ou Chunlei , Deng Le , He Dinggeng
Published: November 2022

Ultra-thin silica-guarded nanoflares (Au@SiO2 NFs) are constructed for high-fidelity live cell microRNA imaging by avoiding the interference of intracellular biothiols.
Dynamics of the alkyne → copper(i) interaction and its use in a heteroleptic four-component catalytic rotor
Authors: Saha Suchismita , Kundu Sohom , Biswas Pronay Kumar , Bolte Michael , Schmittel Michael
Published: November 2022

The dynamics of alkyne → copper(i) interactions has been determined and used to self-assemble a fast nanorotor, which underwent a self-catalyzed click transformation to a triazole rotor, an interesting process for the production of biohybrid devices.
Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes
Authors: Harlington Alix C. , Shearwin Keith E. , Bell Stephen G. , Whelan Fiona
Published: November 2022

Selective O-demethylation of the lignin monoaromatics, syringol and guaiacol, using the peroxygenase activity of two distinct cytochrome P450 enzymes.
Solving a problem with a single parameter: a smooth bcc to fcc phase transition for metallic lithium
Authors: Jerabek Paul , Burrows Antony , Schwerdtfeger Peter
Published: November 2022

DFT calculations show how bcc lithium transforms from being meta-stable to quasi-degenerate with fcc along the martensitic cuboidal path when phonon contributions are added. This resolves a long-standing controversy about these two Li structures.
Thermal-needle-triggered cascade reduction of graphene oxide for controllable moving trajectory into conductive patterns
Authors: Zhang Xiaofang , Zong Lu , Li Mingjie , Zhang Jianming , Li Chaoxu
Published: November 2022

We showed graphene patterning could be triggered by a thermal needle and controlled through pre-infiltrating certain materials into graphene oxide (GO) substrates.
(BA)10AgBi2Br19: a one-dimensional halide double perovskite with a unique Br trimer
Authors: Guo Zhongnan , Ruan Hang , Lin Jiawei , Sun Fan , Liu Kunjie , Chen Xin , Zhao Jing , Yuan Wenxia
Published: November 2022

A novel 1D halide double perovskite, (BA)10AgBi2Br19, is synthesized, which is the first 1D derivative of a double perovskite and features corner-sharing perovskite ribbons and a unique Bi trimer.
Synthesis of naphthalene-substituted aromatic esters via Rh(iii)-catalyzed C–H bond naphthylation and cascade directing group transformation
Authors: Cui Yue , Li Siyu , Wang Hesheng , Zeng Jing , Wang Yichen , Bu Xiubin , Yang Xiaobo , Zhao Zhen
Published: November 2022

An alternative way to the rational use of imidate group in Rh(iii)-catalyzed C–H bond naphthylation, affording a variety of naphthalene-substituted esters with high efficiency and good regioselectivity.
Consecutive photochemical reactions enabled by a dual flow reactor coil strategy
Authors: Crawford Ruairi , Di Filippo Mara , Guthrie Duncan , Baumann Marcus
Published: November 2022

We report the use of a dual flow reactor coil to telescope consecutive photochemical reactions in continuous flow mode.
Recent advances in eco-friendly fabrics with special wettability for oil/water separation
Authors: Xiang Bin , Liu Qiuqiu , Sun Qing , Gong Jingling , Mu Peng , Li Jian
Published: November 2022

Eco-friendly fabrics with special wettability and multifunctional property for oil/water separation.
Eight semiconducting MOFs constructed with conjugated ligands and d-metals (Cd, Zn, Co and Ni) serve as functional materials for oxygen evolution reactions, photocatalytic degradation of dyes and photoluminescence
Authors: Li Yang-Hua , Wang Xin-Ying , Liu Yu-Qi , Dai Si-Yu , Jin Nan-Hao , Chen Han , Liu Xiao-Ming , Zhao Yue , Luo Hui-Long , Li Wei
Published: November 2022

We constructed eight MOFs with semiconductor behavior, discussed their structures in detail, and explored their practical applications.
Single crystal growth and piezoelectric features of the Ca2Nb2O7crystal with orthorhombic symmetry
Authors: Xie Linfang , Hou Shuai , Yu Fapeng , Zhao Xian
Published: November 2022

Centimeter-sized high quality Ca2Nb2O7crystals were successfully grown using the conventional Czochralski pulling method, and the relationship between the crystal structure and physical properties has been clearly explained.
Chain structure and β conformation of poly(9,9-dioctylfluorene) (PFO) with different molecular weights delivering from the solution to the film in a drop-casting process
Authors: Li Tao , He Qilong , Guo Yanan , Guan Yijia , Zhang Yuhua , Cao Weijie , Qin Jieyi , Liao Jianguo , Guan Xuemao , Lu Dan
Published: November 2022

Molecular weight influence on the transformation process of PFO chain and ordered β conformation from the solution to the film in a drop-casting process.
Water interaction with B-site (B = Al, Zr, Nb, and W) doped SrFeO3−δ-based perovskite surfaces for thermochemical water splitting applications
Authors: Chen Sha , Cheng Hongwei , Liu Yanbo , Xiong Xiaolu , Sun Qiangchao , Xu Qian , Lu Xionggang , Li Shenggang
Published: November 2022

First principles calculations predicted metal dopants and surface oxygen vacancies in SrFeO3−δ-based perovskites to benefit H2O dissociation and H2 formation.
How general is the effect of the bulkiness of organic ligands on the basicity of metal–organic catalysts? H2-evolving Mo oxides/sulphides as case studies
Authors: Rovaletti Anna , Ryde Ulf , Moro Giorgio , Cosentino Ugo , Greco Claudio
Published: November 2022

When designing metal catalysts that involve protonation reactions, the modulation of the steric properties of the metal ligands can be as important as the modulation of the electronic properties of the same in controlling the activity of the system.
Electrocatalytic hydrogen production from neutral water using an aqueous Ni(ii) pincer complex
Authors: Norouziyanlakvan Somayeh , Ferguson Jonathan , Richeson Darrin
Published: November 2022

Water provides a sustainable source and solvent for electrocatalytic H2 production from a Ni(ii) complex.
In situ formation of Ni(CO)4 contaminant during IR analyses using a metal-containing reaction cell
Authors: Meunier Frederic C.
Published: November 2022

A corroded DRIFTS cell may lead to Ni(CO)4 formation when exposed to CO, resulting in unexpected Ni carbonyl species at the surface of catalysts.
Gas–solid two-phase flow method for preparing trimesic acid series MOFs for catalytic thermal decomposition of ammonium perchlorate
Authors: Zhang Juan , Zhao Jun , Jin Bo , Peng Rufang
Published: November 2022

The Zn–BTC, Co–BTC and Zn–Co–BTC series MOFs were prepared by using the GSF device and applied in the catalytic thermal decomposition of AP to change the high-temperature thermal decomposition peak of AP.
Effective tuning of magnetic anisotropy in distorted pentagonal bipyramidal Ni(ii) complexes via substitution of axial coligands
Authors: Drahoš Bohuslav , Herchel Radovan
Published: November 2022

Unexpected variation of the magnetic anisotropy in pentagonal bipyramidal Ni(ii) complexes induced by different axial co-ligands due to a strong distortion of the equatorial pentagonal ligand field.
Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications: an updated review
Authors: Bozkurt Osman , Kocaadam-Bozkurt Betül , Yildiran Hilal
Published: November 2022

Effects of Curcumin in Type 2 Diabetes Mellitus (T2DM).
Association of dietary meat consumption habits with neurodegenerative cognitive impairment: an updated systematic review and dose–response meta-analysis of 24 prospective cohort studies
Authors: Quan Wei , Xu Yang , Luo Jie , Zeng Maomao , He Zhiyong , Shen Qingwu , Chen Jie
Published: November 2022

The association between dietary meat consumption habits and neurodegenerative cognitive impairment (NCI) has been made but recent studies have reported controversial results.
Correction: Polysaccharides from Ulva prolifera O.F. Müller inhibit cell proliferation via activating MAPK signaling in A549 and H1650 cells
Authors: Yang Juan Juan , Wang Ye Hua , Yin Jiao , Leng Hong , Shen Song dong
Published: November 2022

Correction for ‘Polysaccharides from Ulva prolifera O.F. Müller inhibit cell proliferation via activating MAPK signaling in A549 and H1650 cells’ by Juan Juan Yang et al., Food Funct., 2021, 12, 6915–6924, https://doi.org/10.1039/D1FO00294E.
One-pot synthesis of cyclohexylphenol via isopropyl alcohol-assisted phenol conversion using the tandem system RANEY® Nickel plus hierarchical Beta zeolite
Authors: García-Minguillán A. M. , Briones L. , Alonso-Doncel M. , Čejka J. , Serrano D. P. , Botas J. A. , Escola J. M.
Published: November 2022

Cyclohexylphenols are valuable intermediate chemicals applied in the manufacture of dyes, resins, and pharmaceutical drugs.
Enhanced photocatalytic ammonia synthesis over a Bi/carbon cloth float: triphase reaction system-assisted N2supply and photothermal co-activation
Authors: Li Yaru , Liu Jianxin , Sun Zijun , Li Rui , Guo Lijun , Zhang Xiaochao , Wang Yawen , Wang Yunfang , Yu Zhuobin , Fan Caimei
Published: November 2022

A novel Bi/CC float is designed to construct a gas–solid–liquid triphase reaction system for improved photocatalytic ammonia synthesis.
A combined photobiological–photochemical route to C10 cycloalkane jet fuels from carbon dioxide via isoprene
Authors: Rana Anup , Cid Gomes Leandro , Rodrigues João S. , Yacout Dalia M. M. , Arrou-Vignod Hugo , Sjölander Johan , Proos Vedin Nathalie , El Bakouri Ouissam , Stensjö Karin , Lindblad Peter , Andersson Leena , Sundberg Cecilia , Berglund Mathias , Lindberg Pia , Ottosson Henrik
Published: November 2022

A photobiological–photochemical process, where sunlight can be used, is shown to convert CO2 to C10 cycloalkane jet fuels. The properties are comparable to commercial aviation fuels and LCA indicates the potential sustainability of the process.
Hydrogels with protective effects against cellular oxidative stress via enzymatic crosslinking of feruloylated arabinoxylan from corn fibre
Authors: Yilmaz-Turan Secil , Jiang Kun , Lopez-Sanchez Patricia , Jiménez-Quero Amparo , Crouzier Thomas , Plivelic Tomás S. , Vilaplana Francisco
Published: November 2022

Corn fibre agricultural side streams can be upgraded into radical scavenging hydrogels with protective effects against cellular oxidative stress using mild biocatalytical processes.
Metal acetylacetonates dissolved in UV-curing resin as solid reference material for trace element measurements in organic samples
Authors: Rogoll Anika , Heimler Korbinian , Friebel Dina , Brendler Erica , Vogt Carla
Published: November 2022

Vacuum stable and microhomogeneous polymer reference materials with trace amounts of different metals will improve the quality of lateral-resolved quantification significantly.
Development of a simultaneous electrorotation device with microwells for monitoring the rotation rates of multiple single cells upon chemical stimulation
Authors: Suzuki Masato , Kawai Shikiho , Shee Chean Fei , Yamada Ryoga , Uchida Seiichi , Yasukawa Tomoyuki
Published: November 2022

Simultaneous electrorotation in microwells during chemical stimulation label-free monitoring effect of chemicals in single-cell manner.
Automation of cell culture assays using a 3D-printed servomotor-controlled microfluidic valve system
Authors: Winkler Steffen , Menke Jannik , Meyer Katharina V. , Kortmann Carlotta , Bahnemann Janina
Published: November 2022

We present a 3D-printed microfluidic valve system for automated liquid handling in cell culture. The published 3D models enable the customization by the scientific community in a DIY approach.
A dental implant-on-a-chip for 3D modeling of host–material–pathogen interactions and therapeutic testing platforms
Authors: Dhall Atul , Tan Jun Ying , Oh Min Jun , Islam Sayemul , Kim Jungkwun , Kim Albert , Hwang Geelsu
Published: November 2022

The entire dental implant microenvironment is successfully replicated in the microfluidic model via unprecedented high-aspect-ratio microchannels separated by closely-spaced micropillars.
Cell deformability heterogeneity recognition by unsupervised machine learning from in-flow motion parameters
Authors: Maremonti Maria Isabella , Dannhauser David , Panzetta Valeria , Netti Paolo Antonio , Causa Filippo
Published: November 2022

This work demonstrates how a small set of motion parameters uniquely measures a wide range of cell deformability in microfluidics.
Synthesis of hydrophilic Ag2Se quantum dots optically optimized by multivariate strategies: an easy one-pot approach
Authors: Viegas Isabelle M. A. , Gonçalves Ingrid W. V. , Santos Beate S. , Fontes Adriana , Pereira Maria Goreti C. , Pereira Claudete F. , Pereira Giovannia A. L.
Published: November 2022

A simple and fast aqueous synthesis of silver selenide quantum dots is proposed with the aid of multivariate optimization.
First representatives of C-glycosyl 1,2,4,5-tetrazines: synthesis of 3-β-d-glucopyranosyl 1,2,4,5-tetrazines and their transformation into 3-β-d-glucopyranosyl pyridazines
Authors: Bokor Éva , Kecskés Dóra T. , Gombás Ferenc , Fehér Alexandra , Kardos Eszter , Dabian Akram , Vonza Zsófia , Szennyes Eszter , Somsák László
Published: November 2022

Syntheses of the first representatives of C-glycosyl s-tetrazines and demonstration of their synthetic utility to get barely known C-glycosyl pyridazines.
Ion-modulated photoluminescence of MoS2 nanoflakes for cell viability detection
Authors: Zhu Xiaona , Wang Zegao , Hu Jing , Lu Zhengcheng , Gao Mingyan , Wang Ying , Song Zhengxun , Dong Mingdong , Wang Zuobin , Klausen Lasse Hyldgaard
Published: November 2022

Cell viability detection plays a crucial role in apoptosis and anticancer drug research.
On the coordination behaviour of diorganoselenium ligands based on amino and azole functionalities: silver(i) complexes with relevance for biological applications
Authors: Popa Roxana A. , David Maria , Licarete Emilia , Banciu Manuela , Silvestru Anca
Published: November 2022

[Ag(OTf)L] complexes (L = RR′Se) were prepared, structurally characterized and tested for their in vitro antiproliferative activity.
A multi-hierarchical 3D conductive construction of a MoP/C-rGO hybrid for a HER catalyst and a LIB anode
Authors: Hou Xuebin , Huang Zelong , Hu Liu , Wei Qufu , Hu Yi
Published: November 2022

A multi-hierarchical 3D conductive network formed by carbon wrapping and rGO sheet support.
Streptomyces cell-free systems for natural product discovery and engineering
Authors: Moore Simon J. , Lai Hung-En , Li Jian , Freemont Paul S.
Published: November 2022

Streptomyces cell-free gene expression (CFE) systems for natural product discovery. The CFE system simply requires DNA, a cell-extract, amino acids, and a metabolite solution to study transcription, translation, and biosynthesis in a single reaction.
Rh(ii)-catalyzed Doyle–Kirmse reaction: access to unprotected 3-allyl/3-allenyl-3-(thio)oxindoles
Authors: Lu Xunbo , Yang Kaiyuan , Xu Xinyu , Sun Siyu , Feng Shanqing , Bashir Muhammad Adnan , Liang Fangpeng , Lin Jie , Huang Guoling
Published: November 2022

A highly efficient Rh(ii)-catalyzed non-radical Doyle–Kirmse reaction, using diazooxindoles and allylic/allenyl sulfides, is disclosed for the first time, providing NH-free C3-difunctional oxindoles under mild conditions.
Renewable green reactive diluent for bisphenol a epoxy resin system: curing kinetics and properties
Authors: Li Jingyu , Zhao Haichao , Sui Guoxin
Published: November 2022

Hydrosilylation epoxidized eugenol (HSI-EP-EU) is successfully synthesized and used as a reactive diluent for epoxy/anhydride and epoxy/imidazole curing systems.
Chinese chemistry motivation questionnaire II: adaptation and validation of the science motivation questionnaire II in high school students
Authors: Zhang Jiafeng , Zhou Qing
Published: November 2022

This study aimed to adapt a new version of the Science Motivation Questionnaire II, the Chinese Chemistry Motivation Questionnaire II, for high school students in China, focusing specifically on chemistry. The sample consisted of 1635 students from four high schools, by stratified random sampling. Data was collected online. Exploratory and confirmatory factor analysis confirmed the original five-component motivation (intrinsic motivation, career motivation, self-determination, self-efficacy and grade motivation) structure after dropping four problematical items, and the factorial invariance was also confirmed across gender, region of residence, and choice of chemistry. Five components were strongly correlated in the Chinese context. Among the five components, students scored the highest in grade motivation. Generally, students who would continue chemistry scored much higher in all five components than those who would discontinue, with boys scoring slightly higher than girls and urban students scoring slightly higher than rural students. Specifically, for students who would continue chemistry, there were medium gender differences in self-efficacy, small gender differences in intrinsic motivation, career motivation, and self-determination, no significant gender differences in grade motivation, and small regional differences in all five components. For students who would discontinue chemistry, there were no significant differences in all five components across gender and region of residence. The internal structure of the questionnaire, correlations among the five components, and group differences in motivation were discussed. Some implications for researchers and practitioners were presented.
High-throughput exploration of activity and stability for identifying photoelectrochemical water splitting materials
Authors: Jenewein Ken J. , Thienhaus Sigurd , Kormányos Attila , Ludwig Alfred , Cherevko Serhiy
Published: November 2022

Activity-stability relations of multinary oxide photoanodes for solar water splitting were measured using an automated flow cell coupled to an ICP-MS and successively visualized with the help of data science tools like principal component analysis.
Preparation of stereocomplex and pseudo-polyrotaxane with various cyclodextrins as wheel components using triblock copolymer of poly(ethylene glycol) and polylactide
Authors: Choi JaeYeong , Ajiro Hiroharu
Published: November 2022

We discuss size effects of CD on the formation of stereocomplex and pseudo-polyrotaxane with triblock copolymers of poly(ethylene glycol) and polylactide.
Correction: Fmoc-diphenylalanine hydrogels: understanding the variability in reported mechanical properties
Authors: Raeburn Jaclyn , Pont Guillaume , Chen Lin , Cesbron Yann , Lévy Raphaël , Adams Dave J.
Published: November 2022

Correction for ‘Fmoc-diphenylalanine hydrogels: understanding the variability in reported mechanical properties’ by Jaclyn Raeburn et al., Soft Matter, 2012, 8, 1168–1174, https://doi.org/10.1039/C1SM06929B.
Mechanism of coupled phase/morphology transformation of 2D manganese oxides through Fe galvanic exchange reaction
Authors: Aymerich-Armengol Raquel , Cignoni Paolo , Ebbinghaus Petra , Linnemann Julia , Rabe Martin , Tschulik Kristina , Scheu Christina , Lim Joohyun
Published: November 2022

A Mn2+ defect-mediated oxidative mechanism was found responsible for the coupled morphology/phase transformation of 2D manganese oxides via Fe galvanic exchange reaction.
Correction: Best practices in the measurement of circularly polarised photodetectors
Authors: Ward Matthew D. , Shi Wenda , Gasparini Nicola , Nelson Jenny , Wade Jessica , Fuchter Matthew J.
Published: November 2022

Correction for ‘Best practices in the measurement of circularly polarised photodetectors’ by Matthew D. Ward et al., J. Mater. Chem. C, 2022, 10, 10452–10463, https://doi.org/10.1039/D2TC01224C.
Unit commitment with frequency‐arresting adequacy constraint: Modelling and pricing aspects
Authors: Davari Nejad Ehsan , Hesamzadeh Mohammad Reza , Orostica Hector Chavez
Published: November 2022

Frequency‐arresting (FA) adequacy has received an increasing attention in operation of power systems with intermittent, electronically connected wind and sfolar generation. Presence of high penetration of renewable energy leads to reduced amount of inertia in the power system and the need for more sustainable market design. This paper addresses the FA adequacy by integrating Nadir and rate of change of frequency constraints in unit commitment formulation. Here, a mixed‐integer linear program (MILP) is proposed for addressing the FA adequacy. The proposed MILP model of FA adequacy is non‐convex and accordingly, FA adequacy pricing requires non‐convex pricing techniques. The explicit and implicit uplift payment techniques are proposed and implemented for FA adequacy pricing using the authors' proposed MILP model. The primal–dual formulation is employed for implicit uplift technique. The proposed MILP model of FA adequacy along with its pricing techniques is carefully studied through an illustrative example system. For further discussions, the Nordic 44‐node test network is studied.
55 Cancri e’s occultation captured with CHEOPS
Authors: Demory B.-O. , Sulis S. , Meier Valdés E. , Delrez L. , Brandeker A. , Billot N. , Fortier A. , Hoyer S. , Sousa S. G. , Heng K. , Lendl M. , Krenn A. , Morris B. M. , Patel J. A. , Alibert Y. , Alonso R. , Anglada G. , Bárczy T. , Barrado D. , Barros S. C. C. , Baumjohann W. , Beck M. , Beck T. , Benz W. , Bonfils X. , Broeg C. , Buder M. , Cabrera J. , Charnoz S. , Collier Cameron A. , Cottard H. , Csizmadia Sz. , Davies M. B. , Deleuil M. , Demangeon O. D. S. , Ehrenreich D. , Erikson A. , Fossati L. , Fridlund M. , Gandolfi D. , Gillon M. , Güdel M. , Isaak K. G. , Kiss L. L. , Laskar J. , Lecavelier des Etangs A. , Lovis C. , Luntzer A. , Magrin D. , Marafatto L. , Maxted P. F. L. , Nascimbeni V. , Olofsson G. , Ottensamer R. , Pagano I. , Pallé E. , Peter G. , Piotto G. , Pollacco D. , Queloz D. , Ragazzoni R. , Rando N. , Ratti F. , Rauer H. , Ribas I. , Santos N. C. , Scandariato G. , Ségransan D. , Simon A. E. , Smith A. M. S. , Steller M. , Szabó Gy. M. , Thomas N. , Udry S. , Van Grootel V. , Walton N. A.
Published: November 2022

Past occultation and phase-curve observations of the ultra-short period super-Earth 55 Cnc e obtained at visible and infrared wavelengths have been challenging to reconcile with a planetary reflection and emission model. In this study, we analyse a set of 41 occultations obtained over a two-year timespan with the CHEOPS satellite. We report the detection of 55 Cnc e’s occultation with an average depth of 12 ± 3 ppm. We derive a corresponding 2σ upper limit on the geometric albedo of Ag < 0.55 once decontaminated from the thermal emission measured by Spitzer at 4.5 µm. CHEOPS’s photometric performance enables, for the first time, the detection of individual occultations of this super-Earth in the visible and identifies short-timescale photometric corrugations likely induced by stellar granulation. We also find a clear 47.3-day sinusoidal pattern in the time-dependent occultation depths that we are unable to relate to stellar noise, nor instrumental systematics, but whose planetary origin could be tested with upcoming JWST occultation observations of this iconic super-Earth.
Singular value representation of the coherence Poincaré sphere
Authors: Laatikainen Jyrki , Friberg Ari T. , Korotkova Olga , Setälä Tero
Published: November 2022

The so-called coherence Poincaré sphere was recently introduced for geometrical visualization of the state of two-point spatial coherence of a random electromagnetic beam. The formalism and its interpretation strongly utilized a specific decomposition of the Gram matrix of the cross-spectral density (CSD) matrix. In this work, we show that the interpretation of the coherence Poincaré sphere is obtained exclusively and straightforwardly via the singular value decomposition of the CSD matrix.
Interaction of high-order breather, periodic wave, lump, rational soliton solutions and mixed solutions for reductions of the (4+1)-dimensional Fokas equation
Authors: Xia Pei , Zhang Yi , Ye Rusuo
Published: November 2022

The interaction of high-order breather, periodic-wave, lump, rational soliton solutions and mixed solutions for reductions of the (4+1)-dimensional Fokas equation are investigated by means of the Kadomtsev-Petviashvili (KP) hierarchy reduction method. Through analyzing the structural characteristics of periodic wave solutions, we find that evolution of the breather is decided by two characteristic lines. Interestingly, growing-decaying amplitude periodic wave and amplitude-invariant periodic wave are given through some conditions posed on the parameters. Some fascinating nonlinear wave patterns composed of high-order breathers and high-order periodic waves are shown. Furthermore, taking the long wave limit on the periodic-wave solutions, the semi-rational solutions composed of lumps, moving solitons, breathers, and periodic waves are obtained. Some novel dynamical processes are graphically analyzed. Additionally, we provide a new method to derive periodic-wave and semi-rational solutions for the (3+1)-dimensional KP equation by reducing the solutions of the (4+1)-dimensional Fokas equation. The presented results might help to understand the dynamic behaviors of nonlinear waves in the fluid fields and may provide some new perspectives for studying nonlinear wave solutions of high dimensional integrable systems.
Gemeinsame Entscheidungsfindung am Lebensende
Authors: Thomas-Krause Paul-Björn
Published: November 2022

Die partizipative Entscheidungsfindung (engl. Shared Decision Making) bietet einen Behandlungsansatz, der Patienten und Angehörige in das Behandlungsgeschehen aktiv einschließt. Wie dies am Ende des Lebens auf der Intensivstation realisiert werden kann, soll der folgende Beitrag näher beleuchten.
First report of complete enteroscopy from ileocecal valve to pylorus by retrograde
motorized power spiral endoscopy
Authors: Steinbrück Ingo , Allgaier Hans-Peter
Published: November 2022

The development of capsule endoscopy and device-assisted enteroscopy (DAE) revolutionized
minimally invasive examination and treatment of small bowel diseases. Limitations of DAE are a
great time expenditure and low rates of complete enteroscopy. Recently motorized spiral
enteroscopy (MSE) was introduced with shorter procedure times and concurrently greater
insertion depths. MSE is also the first device that opens up the possibility to achieve
complete enteroscopy in a relevant number of cases by the unidirectional, peroral
approach.

To our knowledge we present the first published case of complete enteroscopy by retrograde
MSE in a 35-year-old female without prior abdominal surgery with direct endoscopic
visualization of the pyloric ring. The patient suffered from colonic polyposis syndrome. For
the exploration of both colorectum and the small bowel we performed retrograde MSE under
propofol sedation. After 60 minutes of advancement, we achieved complete enteroscopy by
retrograde identification of the pyloric ring. The procedure could be finished after
withdrawal of the endoscope and cold snare polypectomy of 3 small colonic adenomas without any
adverse events. Total procedure time was 82 minutes. The patient was discharged one day after
the procedure without complaints.

It has been proven already that great insertion depths are achievable by retrograde MSE,
but this case shows for the first time that even a complete enteroscopy is possible. In
conclusion, primary retrograde MSE with no need of tracheal intubation might be a key to more
effective, time-preserving, and cost-effective concepts of small-bowel endoscopy in the
future.
Recent Advances in Chiral Aldehyde Catalysis for Asymmetric Functionalization of Amines
Authors: Wen Wei , Guo Qi-Xiang
Published: November 2022

Asymmetric functionalization of amines and their derivatives is of great significance in synthetic chemistry and is widely used in the preparation of natural products and pharmaceuticals. In recent years, chiral aldehyde catalysis has emerged as a well-established and recognized tool, providing excellent catalytic activation and stereoselective control in asymmetric reactions of N-unprotected amino acid esters and amino acid ester analogues. In this short review, recent advances in enantioselective aldehyde catalysis, including chiral aldehydes as organocatalysts and co-catalysis combined with transition metals, will be summarized. Lastly, continued development of enantioselective aldehyde catalysis is prospected in the future.

1 Introduction

2 Chiral Aldehyde Catalysis for Tethering Strategy

3 Chiral Aldehyde Catalysis for Imine Activation

4 Chiral Aldehyde/Transition Metal Cooperative Catalysis

5 Conclusion
Association between Interleukin-6 rs1800795 Polymorphism and Serum Interleukin-6 Levels and Full-Term Neonatal Sepsis
Authors: Zhao Xiao-Fen , Yang Mi-feng , Wu Yu-qin , Zhao Peng-na , Zhu Shuang-Yan , Xiong Fei , Fan Mao , Li Yang-Fang
Published: November 2022

Objective Cytokines are involved in the pathogenesis of sepsis. Association between IL-6 rs1800795 G/C polymorphism and the risks of sepsis is controversial. The aim of this study was to investigate the association of IL-6 rs1800795 G/C gene polymorphism with full-term neonatal sepsis and to determine its effect on the serum IL6 levels in these infants by a prospective study.

Methods The study included 200 full-term neonates from January 2019 to December 2020: 100 with sepsis (sepsis group), 47 with culture proven sepsis, and 53 with clinical sepsis, and 100 without infection (control group). The concentrations of IL-6 in serum were determined using enzyme-linked immunosorbent assay (ELISA). The polymorphisms of IL-6 rs1800795 G/C were analyzed to compare the genotypic and allelic frequencies in the groups by using the first-generation sequencing (Sanger sequencing). The association was studied between IL-6 rs1800795 G/C polymorphisms and serum IL-6 levels, and neonatal sepsis. The relationships between IL-6 rs1800795G/C polymorphisms and sepsis and serum IL-6 levels were separately analyzed by logistic regression and analysis of variance.

Results There were no significant differences in genotypic frequencies and allelic frequencies of IL-6 rs1800795(G/C) in the groups (p >0.05). There were no relations between IL-6 rs1800795G/C polymorphisms and sepsis and serum IL-6 levels by statistical analysis (p >0.05).

Conclusion IL-6rs1800795G/C may not be genetic risk factors for full-term neonates; There was no association between serum IL-6 levels and IL-6 rs1800795G/C polymorphisms.
Prevention of Health Care–Associated Measles Transmission in a Pediatric Clinic
Authors: Kaman Ayşe , Oğuz Melahat Melek
Published: November 2022

Objective Preventive measures in the setting of a suspected measles case in a hospital setting are important to stop the secondary spread. In this report, we evaluated the prevention attempts after two suspected cases of measles were reported in a pediatric clinic.

Methods We evaluated prevention interventions including isolation, intravenous immunoglobulin, or measles–mumps–rubella (MMR) vaccine after two patients were diagnosed with maculopapular rash compatible with measles in the pediatric clinic.

Results There were 50 patients (29 were outpatients, 21 were inpatients), 19 health care personnel (HCP), and 50 caregivers who were in contact with index cases. All of the HCP and 40 of the caregivers were immune to measles. Additional dose of MMR vaccine was recommended to five of the outpatients by phone. A total of 12 patients who were being followed up as inpatients (8 patients aged 6–12 months, 4 patients aged ≥ 12 months) were vaccinated with one dose of MMR vaccine. Only a 12-year-old male patient was admitted due to complaints suggesting measles after 14 days from discharge. It was learned that he had received a single dose of vaccine before so he was recommended an additional dose of MMR vaccine by the phone, but he did not go to the health institution on the day of the call.

Conclusion Postexposure prophylaxis is effective to prevent measles transmission. Although young infants have the highest risk for transmission of measles in a health care–associated outbreak, adolescents and older children who are single vaccinated also have high risk for clinical measles.