bluuebunny/crossref_metadata_2025 huggingface dataset:
Academic Research Responses to Covid-19: The Corporate Social Responsibility Perspective
Authors: Nahar Hairul Suhaimi , Mohamad Maslinawati
Published: May 2023

This study investigates the strategic responses to the Covid-19 pandemic by academic research from the distinctive lens of corporate social responsibility (CSR). Specifically, it examines the evolution and trend of published academic research covering the CSR–Covid-19 nexus by highlighting key characteristics of published theoretical and empirical research linking the two elements. A total of 99 papers on CSR–Covid-19 nexus derived from Scopus database were analysed using bibliometrics, social network techniques and content analysis to examine the research activities since the start of the pandemic up to November 2021. The results indicate that the pandemic had effectively stimulated rapid growth of research interests examining the intertwined nature of CSR and Covid-19 as reflected in the swift proliferation of studies theoretically explaining and empirically testing the roles and impacts of CSR on various Covid-19 outcomes within myriads of domains, including but not limited to health, business practices, economics, and socials. The practical implications of this article lies on its ability to accentuate key research characteristics that early and/or mature researchers should consider when planning their future research trajectory on the link between CSR and Covid-19.
Identification of the Factors Influencing the Cosmetic Products Market (Ukraine Case)
Authors: Sviderska Svitlana , Zhylinska Oksana , Kukhta Pavlo
Published: May 2023

The global cosmetics market is dynamic and significant in size. Cosmetic products’ market is constantly expanding its influence to different target audiences and covers all classes of consumers. Marketing strategy of cosmetics corporations exists on different levels: main (global) and adapted (for the region or definite country). Generally, it connects with different influencing factors. Based on this, the main aim of this study is to identify and evaluate the key factors globally and evaluate the same for the Ukrainian market. To collect data about global tendencies authors accumulated existing statistical data, annual reports and scientific papers on this topic. For receiving results and collecting data about Ukrainian consumers, close-ended questionnaires were used as a method of collecting preliminary information. Results were classified, most important key success factors were highlighted and then machine learning techniques were used to provide an analysis of correlation. Our results demonstrated that despite the general difference of financial well-being of consumers in USA, Canada and European countries, Ukraine does not differ in consumer preferences by price, as a main factor. For sure it should be noticed, that price is the most influential in third world countries, but Ukrainian market has its own more influential specific factors.
A Sectoral-Based Approach to the Link Between Financial Performance and Sustainability
Authors: Șerban Radu-Alexandru , Mihaiu Diana Marieta , Herciu Mihaela , Ogrean Claudia
Published: May 2023

The main objective of this paper is to analyze if there is a link between financial performance and sustainability in the case of listed companies on stock markets, worldwide, and across all sectors of activity because sustainability has become an important part of the company’s strategy. The financial performance of the companies was calculated using public financial data from the annual financial statements, while the environmental, social, and governance (ESG), and controversies scores were used as performance metrics for sustainability at company level. To evaluate financial performance a variety of indicators were used, such as assets management, debt management or market value performance, as a benchmark tool to compare the standing of companies in each sector of activity analyzed. Our findings showed that there are different relations (strong or weak) between financial performance and sustainability if a sectoral-based approach is considered. As a result, the link between financial performance and sustainability was tested on a sample of more than 5,000 companies divided into 10 sectors of activities, according to the Global Industry Classification Standard (GICS), for the period 2017-2021. The main conclusion of this study is that they are interrelated, capitalizing on each other.
Israel, de José Revueltas: el montaje como técnica en la dramaturgia
Authors: Loza León Juan Luis
Published: May 2023

El artículo aborda la manera en que el montaje, como procedimiento técnico de creación, tiene lugar en el texto dramático Israel, del autor mexicano José Revueltas. La primera sección del trabajo ofrece elementos críticos para una revisión de los antecedentes temáticos en la obra narrativa y periodística del autor hasta 1947. En la segunda, se presenta la singularidad de la técnica del montaje de tipo cinematográfico presente en Israel, vinculando espacio, personajes, objetos escénicos e iluminación. En la tercera sección se analizan los tres actos del drama para demostrar la operación del montaje en el argumento de la historia, lo que permite apreciar su efectividad.
Israel, by José Revueltas: Montage as a Dramaturgical Technique
Abstract
The article aims to demonstrate the way in which montage as a technical procedure of writing is deployed in the play Israel, by Mexican author José Revueltas. The article’s first section offers a critical overview of the thematic background in the author’s narrative and journalistic work until 1947. The second presents the technique of cinematographic montage that can be found in Israel as a writing procedure that links space, characters, stage objects and lighting. The third section discusses each of the drama’s three acts, to identify the use of montage in the story’s plot, a technique that makes the dramatic text particularly effective.
Recibido: 11 de octubre de 2022
Aceptado: 09 de marzo de 2023
Sazonalidade da bronquiolite em recém-nascidos e lactentes jovens em tempos de pandemia pelo SARS-CoV-2
Authors: Paiva Vitoria , Falcão Mário , Matsushita Felipe , Yoshimoto Cristina
Published: May 2023

OBJETIVOS: Comparar a frequência de recém-nascidos e lactentes jovens internados com bronquiolite em uma unidade de terapia intensiva neonatal externa antes e durante o primeiro ano de pandemia pelo SARS-CoV-2. MÉTODOS: Estudo retrospectivo, incluindo crianças de até 45 dias de vida, com bronquiolite, internados nos anos de 2018, 2019 e 2020. Foram selecionados dos prontuários: sexo; idade e peso à admissão; agente etiológico; tipo de suporte ventilatório; tempo de internação e desfecho. Análise estatística: comparação entre grupos por frequência (qui-quadrado), por média (ANOVA), por mediana (Mann-Whitney). RESULTADOS: Em 2018, a frequência de internações por bronquiolites foi de 6,4%, em 2019, 4,2% e em 2020, 1,3%. Média de idade na internação (dias) (2018 - 33,7, 2019 - 33,7, 2020 - 31,6); peso médio à admissão (gramas) (2018 - 2978, 2019 - 3855 e 2020 - 3873); Agente viral isolado (2018 - 28,5%, 2019 - 55,5% e 2020 - 66,6%); ventilação mecânica invasiva (2018 - 14,3%, 2019 - 44,4% e 2020 - 100%); tempo médio de internação (dias) (2018 - 8 (7-12), 2019 - 5 (4-10), 2020 - 12 (8-16)); alta hospitalar em 100% dos casos. CONCLUSÃO: Em 2020, houve uma redução drástica no número de internações por bronquiolite, justificada pelo isolamento social que resultou em menor circulação de vírus respiratórios.
Pediatric clinical trial profile for COVID-19 at ClinicalTrials.gov: a systematic review
Authors: Covolan Marina , Tsuruda Luiza , Silva Daniela , Barbosa David , Pasa Rubens , Kavalco Karine , Menegidio Fabiano
Published: May 2023

INTRODUCTION: COVID-19 is an extremely serious infectious disease. However, few studies have focu-sed on the drug treatment of pediatric patients affected by COVID-19. OBJECTIVE: Thus, this study conducted a review of clinical trials registered in the Clinical Trials database on drug treatment in pe-diatric patients with COVID-19. METHODS: A systematic search was conducted in the Clinical Trials database (https://clinicaltrials.gov/) using the web tracking technique to collect registered clinical tri-als that conducted drug treatment in pediatric patients aged 0 to 17 years. After the drugs used were identified, their dosage and other pertinent information were obtained from the DrugBank databases (https://go.drugbank.com) and the DrugBase (https://www.drugbase.de). RESULTS: Eight clinical trials were found in the research, classified as completed and 34 in progress, aimed at pediatric patients. The United States was the country that most research involving the drug use in patients with pedia-tric COVID-19. Hydroxychloroquine was the most observed drug in the treatment of pediatric pa-tients, followed by remdesivir. An increase in phase 3 and randomized trials was also observed among ongoing research when compared to completed research. CONCLUSION: Compared to adults, pedia-tric COVID-19 has distinct treatment needs. Thus, it is important to complete the clinical trials de-scribed in the present study, in addition to more randomized clinical trials, before any therapy or other objects related to the clinical management processes for COVID-19 can be properly recom-mended and applied in pediatric treatment.
Diabetic ketoacidosis in a pediatric patient associated a COVID-19: case report
Authors: Pádua Kamilla , Silva Bruna , Silva Glaucia , Albuquerque Wânia , Paula Fernando , Oliveira Alessandra , Alves Maria Carolina
Published: May 2023

The pandemic caused by COVID-19 triggers a disease that manifests itself through flu-like symptoms from mild to severe, up to varied clinical presentations, involving different organs and systems. In pediatric patients, COVID-19 has shown milder manifestations compared to adult patients. The authors report in this article a case that suggest diabetic ketoacidosis (CAD) as the initial manifestation of COVID-19, in a 13-year-old female patient, previously diagnosed with type I diabetes mellitus, admitted to a pediatric emergency room with symptoms CAD compatible, later tested positive for COVID-19. This article discusses the importance of considering COVID-19 infection as a cause of diabetic decompensation in the pediatric population and the possibility of this relationship helping to discover new mechanisms of the disease.
The development of APIO : Solar Power Plant Based Technology for Automatic Fish Dryer Equipment
Authors: Arnita Arnita , Cahayahati Cahayahati , Mirzazoni Mirzazoni
Published: May 2023

APIO is a fish drying equipment that utilizes sunlight which is converted into electrical energy using a solar power plant. This dryer works automatically using a control system that can control temperature and weight in predetermined settings. APIO designed in the form of a closed box with a heater and fan using a battery as an energy source. APIO uses a load cell and thermocouple as control input using an Arduino microcontroller and regulates the heat temperature in the box between 40-50?C. This tool was tested in the Pasie Nan Tigo Padang, Sumatra Barat. APIO tested using the Arduino uno control at night from 23:00 to 03:15 using fish weighing 5108 grams, data collection was carried out once for 15 minutes for 18 times. The average heater temperature was 32.71?C and the outside temperature was 25?C. The heater voltage was 11.33 V and the heater current was 36.02 A with clear weather conditions. The test results showed a decrease in fish weight to 4208 grams dry. Day time tested from 13:00 to 15:15 using fish weighing 1012 grams, taking data once for 15 minutes for 10 times the average heater temperature is 43.85?C, outside temperature is 30?C and fish weight reaches 208 grams dry.
Pengecilan Ukuran Partikel Dan Karakterisasi kolagen dari Kulit Ikan Gabus (Channa Striata) Dengan Metode Ball Milling
Authors: Agustin Rini , Arta Dwi Ramasepti , Nofita Rahmi
Published: May 2023

Isolasi kolagen dari kulit ikan biasanya menghasilkan kolagen dalam bentuk serat padat yang tidak larut dalam air. Pembentukan partikulat kolagen dalam ukuran yang lebih kecil bahkan sampai mencapai ukuran nanometer menjadi hal yang penting terkait dengan aplikasi farmasetis kolagen. terutama dalam pembentukan sistem dispersi kolagen untuk aplikasi topikal. Penelitian ini bertujuan untuk mendapatkan mikropartikulat kolagen hasil isolasi kulit ikan gabus (Channa striata) dalam ukuran yang lebih kecil menggunakan ball milling dengan variasi jumlah bola (75 dan 100 bola) dan  waktu penggilingan (30, 60, 120 dan 180 menit). Kolagen yang diperoleh dikarakterisasi sifat fisikokimianya meliputi ukuran partikel, sifat termal, pola difraksi sinar X, morfologi dengan SEM dan spektrum Infra merah. Mikropartikel kolagen dengan ball milling memiliki ukuran  4,653 µm dengan penggilingan yang optimal pada jumlah bola sebanyak 100 buah dalam waktu 120 menit. Karakteristik dari mikropartikel menunjukkan terjadinya pengurangan ukuran partikel pada kolagen, tidak terjadinya perubahan pada gugus fungsi dengan uji spektroskopi inframerah, adanya penurunan titik leleh dari hasil termogram DSC, penurunan intensitas pola difraksi sinar-X dan tampak fibril yang saling berhubungan dalam kumparan acak pada pengamatan dengan SEM. Dari penelitian ini dapat disimpulkan metoda ball milling untuk pengecilan ukuran partikel kolagen yang diisolasi dari kulit ikan gabus (Channa striata) dapat mengurangi ukuran partikel dengan penurunan 327 kali dan tidak terjadinya perubahan struktur triple helix pada kolagen hasil optimasi.
Kajian Pola Irama Ostinato Pada Busur Lingkaran
Authors: Herisman Iis , Komar Baihaqi  , Rinurwati  , Soleha  , Dian Winda Setyawati
Published: May 2023

Irama merupakan salah satu unsur dasar musik, terbentuk dari perpaduan sekelompok bunyi dan diam serta berbagai macam garis waktu dan panjang pendek tempo. Salah satu pola irama adalah Ostinato merupakan pola irama yang memiliki ciri khusus dengan suara yang didengar berulang-ulang dan berlangsung secara teratur sepanjang lagu, sehingga membentuk satuan irama. Garis waktu dari irama  ostinatos ritme mudah dikenali dan diingat serta memiliki peran penting dalam musik. Selain itu berperan sebagai  fungsi konduktor untuk mengatur dan dapat memberi isyarat kepada musisi melalui   fundamental struktur siklik dari potongan-potongan irama tersebut. Tujuan  penelitian akan mengkaji hasil pola irama  yang telah direkam oleh alat elektrokardiogram  dalam  diagram skematik, dengan  tuts-tuts yang diberikan terbagi menjadi tuts bunyi  dan diam. Pola irama Ostinato merupakan periodik atau berulang- ulang selanjutnya ditransformasikan kebentuk busur lingkaran sebagai tempat kedudukan dari tuts-tuts tersebut. Hasil  penelitian merupakan lingkaran yang membentuk poligon dengan sisinya merupakan garis waktu irama antar  setiap tuts bunyi dengan tuts suara berikutnya.

Kata Kunci: Ostinato, tuts, garis waktu, poligon
Transfusion-related acute lung injury and transfusion-associated circulatory overload: Clinicoradiographic picture of common entities uncommonly reported!!
Authors: Bhayana Aanchal , Swarup M. Sarthak , Thakur Preeti , Kumar Pravin , Garg Devansh
Published: May 2023

Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are post-transfusion life-threatening pulmonary complications. We report a case of TRALI in a 25-year-old postpartum female. Various investigators in past have published these entities in critical care/hematology literature; however, there is a lack of awareness among reporting radiologists, due to paucity of literature in radiology journals. This report aims at discussing clinicoradiographic picture of TRALI and its close differential TACO. This would help in enhancing knowledge of these uncommonly reported entities, and preventing significant morbidity and mortality by initiating appropriate management by critical care clinicians.
Clinicoradiological profile of idiopathic intracranial hypertension
Authors: Yadav Praveen Kumar
Published: May 2023

Objectives:

Idiopathic intracranial hypertension (IIH) is a condition of raised intracranial pressure (ICP) in the absence of a space-occupying lesion. IIH patients usually present with typical symptoms and signs of increased ICP, such as headache, vomiting, neck pain, double vision, transient visual obscuration (TVO), and papilledema. Typical magnetic resonance imaging (MRI) findings include empty sella turcica, optic nerve tortuosity, globe flattening, and transverse sinus stenosis.

Material and Methods:

All patients from July 2021 to June 2022 presented to the super-specialty neuroclinic with symptoms suggestive of IIH were included in this study after consent. Clinical patterns and MRI brain findings along with other risk factors and comorbidities were studied.

Results:

Total 12 patients were studied out of which all were female. The most common age group was 31–40 years (41.6%). The most common clinical presentations were headache and TVOs followed by painless loss of vision, visual field changes and double vision. In this study, 7 out of 12 cases presented with headache (58.3%) out of which only 3 were migrainous. TVOs were presenting complaints of 7 patients (58.3%). Painless visual loss was there in 3 patients (25%), out of which only one case was bilateral (33%). In all cases (100%), MRI was suggestive of IIH. Transverse sinus stenosis in 3 cases (25%) and scleral flattening in 1 case (14.2%) were seen, respectively.

Conclusion:

Clinical suspicion followed by MRI brain is of utmost importance. Prompt diagnosis and treatment are essential in IIH patients to prevent permanent visual loss.
THE STRUCTURE OF INTRODUCTION CENOPOPULATION OF ACER NEGUNDO IN THE URBAN ENVIRONMENT
Authors: Путенихин В.П. , Ахмедьянов Д.И. , Габидуллина Г.Ф. , Дубовик И.Е. , Ишбирдин А.Р. , Путенихина К.В. , Тельцова Л.З. , Турьянова Р.Р. , Шарипова М.Ю.
Published: May 2023

В городской интродукционной ценопопуляции Acer negundo L. 55-летний древостой характеризуется низкой продуктивностью и ослабленным жизненным состоянием. В возрастной структуре ценопопуляции преобладают виргинильные растения (около 77%). Мужских особей (65%) почти в 2 раза больше, чем женских (35%), к тому же они имеют лучшую жизненность. Семенное возобновление весьма значительное – 53 тыс. шт./га. Высокая репродуктивная способность вида определяет возможность его активного расселения за пределы искусственных посадок.

In the urban introduction cenopopulation of Acer negundo L., the 55-year-old stand is characterized by low productivity and weakened viable state. The age structure of the cenopopulation is dominated by virginal plants (about 77%). Male individuals (65%) are almost 2 times more than females (35%), besides they have better vitality. Seed regeneration is very significant – 53 thousand units/ha. The high reproductive capacity of the species determines the possibility of its active settlement beyond artificial plantings.
DIVERSITY OF SOIL FUNGAL COMMUNITIES IN MONOCULTURE AND CROP ROTATION (ON THE EXAMPLE OF THE LONG-TERM EXPERIENCE OF THE RGAU – MTTA NAMED AFTER K.A. TIMIRYAZEV)
Authors: Альсаед Н. , Селицкая О.В.
Published: May 2023

Проведено исследование почвенных микробных сообществ под разными сельскохозяйственными растениями (лён, клевер, ячмень, картофель, озимая рожь), выращиваемыми в бессменных посевах и севооборотах. Для исследования использован ряд молекулярно-генетических методов, таких как выделение ДНК, амплификация, высокопроизводительное секвенирование на платформе MiSeq (Illumina, США). В реестре стационарных длительных полевых опытов продолжительностью 100 и более лет находится опыт российского государственного аграрного университета – МСХА имени К.А. Тимирязева, заложенного в 1912 году профессором А.Г. Дояренко. Показано, что у грибов наибольшее значение оперативных таксономических единиц (далее – ОТЕ) было в почве под паром и севооборотом. Севооборот способствовал увеличению значения индекса Шеннона и Чао1 по сравнению с монокультурой, и секвенированием установлено, что большее общее разнообразие грибов с относительной численностью более 1% характерно для почв под монокультурами в зависимости от вида сельскохозяйственных культур (под льном обнаружено 17 родов, под картофелем – 10 родов). Все образцы почвы содержали грибы рода Mortierella и Fusarium, и наблюдается увеличение процента фитопатогенных грибов в составе микробного сообщества при монокультуре.

A study was made of soil microbial communities under various agricultural plants (flax, clover, barley, potatoes, winter rye) grown in permanent crops and crop rotations. For the study, a number of molecular genetic methods were used, such as DNA isolation, amplification, and high-throughput sequencing on the MiSeq platform (Illumina, USA). In the register of stationary long-term field experiments lasting 100 years or more, there is the experience of the Russian State Agrarian University – Moscow Agricultural Academy named after K.A. Timiryazev, founded in 1912 by Professor A.G. Doyarenko. It was shown that in fungi the highest value of operational taxonomic units (hereinafter referred to as OTU) was in the soil under fallow and crop rotation. Crop rotation contributed to an increase in the Shannon and Chao1 index values compared to monoculture, and sequencing found that a greater overall diversity of fungi with a relative abundance of more than 1% is characteristic of soils under monocultures, depending on the type of crops (17 genera were found under flax, 10 genera under potatoes). childbirth). All soil samples contained fungi of the genus Mortierella and Fusarium, and an increase in the percentage of phytopathogenic fungi in the composition of the microbial community was observed during monoculture.
SPECIFIC FEATURES OF WOODY PLANTS IN THE ACCUMULATION OF HEAVY METALS AND TYPES OF THEIR DISEASES IN SOUTHWESTERN ADMINISTRATIVE DISTRICT AND NORTHEASTERN ADMINISTRATIVE DISTRICT OF MOSCOW.
Authors: Еременко К.В. , Зубкова В.М.
Published: May 2023

В статье приведены данные мониторинга поражаемости болезнями древесных растений и накопления в листьях тяжелых металлов на оживленных магистралях общегородского назначения ЮЗАО и СВАО г. Москвы за период 2019–2021 гг. В ходе анализа выявлены характерные признаки поражения вегетативных органов зеленых насаждений – усыхание кроны, пятнистости, деформация листовой пластины, налёт. Определены патогены, вызывающие болезни растений, обнаружено 23 возбудителя болезней в СВАО и 21 в ЮЗАО. По сумме превышения концентраций (СПК) ТМ в листьях по сравнению с фоновым содержанием установлена в основном обратная зависимость между содержанием ТМ в листьях и пораженностью их болезнями, зависящая от видовых особенностей растений.

The data, presented here, is the result of monitoring the incidence of diseases of woody plants on busy city highways of the Southwestern Administrative District and the Northeastern Administrative District of Moscow conducted in order to track the accumulation of heavy metals in their leaves for the period of 2019-2021. The analysis revealed characteristic feature of damage of the vegetative organs of green plants – crown rot, plant-spotting, deformation of the leaf plate, plant plaque. Pathogens causing plant diseases were identified, there are 23 pathogens detected in the Southwestern Administrative District and 21 in the Northeastern Administrative District of Moscow. According to the amount of excess concentration of heavy metals in the leaves compared to the external concentration of heavy metals the inverse dependence between the concentration of heavy metals in the leaves and their incidence of diseases was established. It depends on the specific features of the trees.
GENDER DIFFERENCES IN THE COURSE OF ARTERIAL HYPERTENSION AT THE OUTPATIENT STAGE
Authors: Шадрина С.С. , Донская А.А. , Софронова С.И. , Скрыбыкина Е.И. , Нечаева Т.В. , Силина Н.Н. , Борисова Е.П.
Published: May 2023

Проведено исследование 80 пациентов с артериальной гипертензией (АГ) на амбулаторном этапе, в ходе которого выявлены гендерные различия течения АГ. Выявлено, что у мужчин АГ протекает тяжелее, чем у женщин, поскольку у них чаще диагностируются гипертрофия левого желудочка, атеросклероз и снижение функции почек, что повышает риск коронарных событий и развития гипертонического нефросклероза. Полученные результаты подтверждают о возможно низкой осведомленности, неэффективной коррекции факторов риска и нерегулярном самоконтроле АД у мужского населения на уровне амбулаторного звена.

A study of 80 patients with arterial hypertension (AH) at the outpatient stage was conducted, during which gender differences in the course of hypertension were revealed. It was revealed that hypertension is more severe in men than in women, since they are more often diagnosed with left ventricular hypertrophy, atherosclerosis and decreased kidney function, which increases the risk of coronary events and the development of hypertensive nephrosclerosis. The results obtained confirm the possible low awareness, ineffective correction of risk factors and irregular self-monitoring of blood pressure in the male population at the outpatient level.
IMMUNOGENETIC MECHANISMS OF CHRONIC POLYPOUS RHINOSINUSITIS (LITERATURE REVIEW)
Authors: Зарубина С.А. , Левченко А.С. , Пискунов В.С. , Пискунов И.С. , Мезенцева О.Ю. , Честникова С.Э. , Лазарев А.И.
Published: May 2023

В настоящее время считается, что хронический полипозный риносинусит – это заболевание, характеризующееся длительным течением, образованием полипозных разрастаний в носу и придаточных пазухах, склонных к рецидивам. Однако несмотря на многочисленные исследования, на сегодняшний день не существует общепринятой теории этиопатогенеза данной патологии. В статье рассмотрены иммуногенетические особенности хронического полипозного риносинусита. Показано, что механизмы патогенеза хронического полипозного риносинусита основаны не только на дисбалансе иммунокомпетентных клеток, но и на действии генов. В статье приведены примеры вовлеченности наиболее важных цитокинов в развитии воспаления при этой патологии. Представленные результаты исследований отечественных и иностранных ученых доказывают значимую роль иммуногенетических факторов в развитии данного заболевания.

It is currently believed that chronic polypous rhinosinusitis is a disease characterized by a long course, the formation of polypous growths in the nose and paranasal sinuses, prone to relapse. However, despite numerous studies, today there is no generally accepted theory of the etiopathogenesis of this pathology. The article discusses the immunogenetic features of chronic polypous rhinosinusitis. It is shown that the mechanisms of pathogenesis of chronic polyposis rhinosinusitis are based not only on the imbalance of immunocompetent cells, but also on the action of genes. The article provides examples of the involvement of the most important cytokines in the development of inflammation in this pathology. The presented results of studies by domestic and foreign scientists prove the significant role of immunogenetic factors in the development of this disease.
USE OF GAS PULSE TREATMENT IN THE PROCESS OF RESTORATION REPAIR OF AIRCRAFT STRUCTURAL ELEMENTS
Authors: Иванов Д.А.
Published: May 2023

В данной статье представлены результаты исследования в области методологии восстановительного ремонта элементов конструкции воздушных судов в части бездеформационных упрочняющих и восстанавливающих технологий на примере обработки дозвуковыми пульсирующими воздушными потоками ремонтируемых авиационных деталей и конструкций. Показана возможность получения значительного положительного технического и экономического эффекта от использования данного вида обработки при восстановительном ремонте авиационной техники.

This article presents the results of a study in the field of the methodology of restorative repair of aircraft structural elements in terms of non-deformational strengthening and restoring technologies on the example of processing by subsonic pulsating air flows of repaired aircraft parts and structures. The possibility of obtaining a significant positive technical and economic effect from the use of this type of treatment during the restoration repair of aviation equipment is shown.
MASSA Algorithm: automated rational sampling of training and test subsets for QSAR modelling
Authors: Veríssimo Gabriel Corrêa , Panteleão Simone Queiroz , Gertrudes Jadson Castro , Kronenberger Thales , Honório Kathia Maria , Maltarollo Vinicius Gonçalves
Published: May 2023

QSAR models capable of predicting biological, toxicity, and pharmacokinetic properties were widely used to search lead bioactive molecules in chemical databases. The dataset’s preparation to build these models has a strong influence on the quality of the generated models, and sampling requires that the original dataset be divided into training (for model training) and test (for statistical evaluation) sets. This sampling can be done randomly or rationally, but the rational division is superior. In this paper, we present MASSA, a Python tool that can be used to automatically sample datasets by exploring the biological, physicochemical, and structural spaces of molecules using PCA, HCA, and K-modes. The proposed algorithm is very useful when the variables used for QSAR are not available or to construct multiple QSAR models with the same training and test sets, producing models with lower variability and better values for validation metrics. These results were obtained even when the descriptors used in the QSAR/QSPR were different from those used in the separation of training and test sets, indicating that this tool can be used to build models for more than one QSAR/QSPR technique. Finally, this tool also generates useful graphical representations that can provide insights into the data.
Structural Evolution of Water-in-Propylene Carbonate Mixtures Revealed by Experimental Raman Spectroscopy and Molecular Dynamics
Authors: Clark Jessica B. , Bowling-Charles Tai , Proma Shamma Jabeen , Biswas Biswajit , Limmer David T. , Allen Heather C.
Published: May 2023

The liquid structure of systems wherein water is limited in concentration or through geometry is of great interest in various fields such as biology, materials science, and electrochemistry. Here, we present a combined polarized Raman and molecular dynamics investigation of the structural changes that occur as water is added incrementally to propylene carbonate (PC), a polar, aprotic solvent that is important in lithium-ion batteries. Polarized Raman spectra of PC solutions were collected for water mole fractions from 0.003 to 0.296, which encompasses the solubility range of water in PC. Analysis of the polarized carbonyl Raman band in conjunction with simulations demonstrated that the bulk structure of the solvent remained unperturbed upon the addition of water. Experimental spectra in the O-H stretching region were decomposed through Gaussian fitting into sub-bands and studies on dilute HOD in H2O. With the aid of simulations, we identified these different bands as water arrangements having different degrees of hydrogen bonding. The observed water structure within PC indicates that water tends to self-aggregate, forming a hydrogen bond network that is distinctly different from the bulk and dependent on concentration. For example, at moderate concentrations, the most likely aggregate structures are chains of water molecules, each with two hydrogen bonds on average.
Critical assessment of covered chemical space with LC-HRMS non-targeted analysis
Authors: Hulleman Tobias , Turkina Viktoriia , O’Brien Jake W. , Chojnacka Aleksandra , Thomas Kevin V. , Samanipour Saer
Published: May 2023

Non-targeted analysis (NTA) has emerged as a valuable approach for comprehensive monitoring of chemicals of emerging concern (CECs) in the exposome. The NTA approach, theoretically, is able to identify compounds with diverse physicochemical properties and sources. Non-targeted analysis methods, even though generic and wide scoping, have been shown to have limitations in terms of their coverage of the chemical space, as the number of the identified chemicals in each sample is very low (e.g. < 5%). Investigating the chemical space covered by each NTA assay is crucial for understanding the limitations and challenges associated with the workflow from experimental methods to the data acquisition and data processing. In this review, we examined recent NTA studies published between 2017 and 2023 that employed liquid chromatography-high resolution mass spectrometry. The parameters used in each study were documented and reported chemicals at the confidence level 1 and 2 were retrieved. The chosen experimental setups and the quality of reporting were critically evaluated and discussed. The findings revealed that only around 2% of the estimated chemical space (i.e. Norman SusDat) was covered by the NTA studies investigated. Little to no trend was found between the experimental setup and the observed coverage, due to the generic and wide scope of NTA studies. The limited coverage of chemical space by the NTA studies highlights the necessity for a more comprehensive approach in experimental and data processing setups to enable the exploration of a broader range of chemical space, with the ultimate goal of protecting human and environmental health. Recommendations to further explore a wider range of the chemical space were given.
Asymmetric Synthesis of Unnatural α-Amino Acids through Photoredox-Mediated C–O Bond Activation of Aliphatic Alcohols
Authors: Alvey Gregory R. , Stepanova Elena V. , Shatskiy Andrey , Lantz Josefin , Willemsen Rachel , Munoz Alix , Dinér Peter , Kärkäs Markus D.
Published: May 2023

An efficient protocol for the asymmetric synthesis of unnatural amino acids is realized through photoredox-mediated C–O bond activation of oxalate esters derived from aliphatic alcohols as the radical precursors. The developed system uses chiral glyoxylate-derived N-sulfinyl imine as the radical acceptor and allows quick access to a range of functionalized unnatural amino acids through an atom-economical redox-neutral process with CO2 as the only stoichiometric by-product.
Realistic phase diagram of water from "first principles" data-driven quantum simulations
Authors: Bore Sigbjørn L. , Paesani Francesco
Published: May 2023

Since the experimental characterization of the low-pressure region of the phase diagram of water in the early 1900s, scientists have been on a quest to understand the thermodynamic stability of ice polymorphs on the molecular level. In this study, we demonstrate that combining the MB-pol data-driven many-body potential for water, which was rigorously derived from “first principles” and exhibits chemical accuracy, with advanced enhanced-sampling algorithms, which correctly describe the quantum nature of molecular motion and thermodynamic equilibria, enables computer simulations of the phase diagram of water with an unprecedented level of realism. Besides providing unique insights into how enthalpic, entropic, and nuclear quantum effects shape the free-energy landscape of water, we demonstrate that recent progress in data-driven many-body potentials and simulation algorithms has effectively opened the door to realistic computational studies of complex molecular systems, thus bridging the gap between experiments and simulations.
Thiele’s Fluorocarbons: Stable Diradicaloids with Efficient Vis-NIR Fluorescence from a Zwitterionic Excited State
Authors: Liu Cheng-Hao , He Zhechang , Ruchlin Cory , Che Yuxuan , Somers Kyle , Perepichka Dmytro
Published: May 2023

Thiele’s hydrocarbon was the first synthesized diradicaloid in the search for stable open-shell structures but itself remains sensitive to oxygen and light. We here report the synthesis of Thiele’s fluorocarbon (TFC) and its derivatives exhibiting exceptional thermal, oxidative, and photostability. TFCs have remarkable luminescent properties with yellow to NIR fluorescence and up to 100% quantum yields. X-ray crystallography and ESR spectroscopy confirm their closed-shell quinoidal ground state. As expected from their uniform HOMO/LUMO distributions, TFCs’ absorption spectra show no solvent effect, but their emission reveals an extraordinarily large Stokes shift which increases with solvent polarity (from 0.9 eV in cyclohexane to 1.5 eV in acetonitrile). We show that this behavior is a result of sudden polarization leading to a zwitterionic excited state.
THE ROLE OF POLITICAL ADVERTISING IN COMMUNICATIVE ACTIVITIES AS A FACTOR IN THE FORMATION OF IMAGES OF THE LEADER
Authors: Koval Vitalii
Published: May 2023

The article defines the formation of images of the leader through political advertising, analyzes the concepts of "communication", "leader", "social demand", "political advertising", explores the role of social demand for leaders, information factors in the formation of images of the leader. The peculiarities of the formation of the image of a leader in advertising, in particular political, in the process of communicative activity, the essence of the concept of leadership, and ways of its formation are highlighted. The principle of the emergence of a social demand for leadership, the preconditions and consequences of the actions of political advertising in society are studied. Taking into account the qualitative characteristics of society, the attitude of the public to social change, to the leadership of individuals, ways of interacting with each other is determined.

The relevance of the article is determined by modern realities in terms of active informatization, politics, socialization and "digitalization" of society in a democracy. The interdependence of society and government, the principles of public formation of politicians, and the effectiveness of their existence in the communicative space, the role of image strategies, political advertising technologies, tasks, components and features of political advertising, other factors influencing the formation of political leader.

Understanding political and social advertising in the context of communicative activities provides an understanding of modern social communication processes. Due to social processes, they become more and more complex every year, as new tools of advertising influence and new barriers to the trust of the target audience appear. In particular, voters have their own habits of determining sympathy for certain parties or political leaders, which are difficult to change. However, the rational formation of images of elites makes it possible to form the right messages for society.

The problem is that the effectiveness of methods of forming the image of a leader depends on the chosen strategy and characteristics of certain parts of society. Studies of the peculiarities of society, their characteristics and social demands allow you to effectively manage the process of becoming a leader. Given the changing social dynamics of society, in the article we also showed that some leaders no longer meet modern requirements, and then they are replaced by others. The article analyzes the system of counteractions, as a result of which the social dynamics of change of leaders in society is possible.
PURPOSE OF METAPHYSICS: APOLOGY OF OVERAGE
Authors: Yatsenko Olena
Published: May 2023

The article consistently substantiates the statement about the non-contextual nature of metaphysical knowledge. It is proved that metaphysics as knowledge of the limit level of abstraction determines the context, which gives it the status of a pure theory of the universal essential foundations of existence and knowledge of the world. Also, metaphysics as a speculative level of boundary abstractions determines the general contour of the realization of culture, on the specific historical interpretation of which depends the content of the cultural space of human existence. It is hypothesized that the metaphysics of culture emphasizes the constant principles of the specificity of human existence, and the effectiveness and efficiency of reflection on the phenomenon of culture is carried out by determining the fundamental for a particular era dialectical contradiction. Accordingly, metaphysics is a pronounced semantic construction of culture, which produces a certain type of thinking, memory and identification, i.e. subjectivity; and sociality as an ethical-axiological model of interaction with the Other. It is argued that classical metaphysics since its inception and throughout its long, meaningful and productive existence is a kind of orientation in space. The author argues that culture is a collection of space in an intelligible structure, the specific nature of human existence in the universe, the way of human being in the world. Space in the metaphysics of culture means the area of localization of the "Ego" and the field of transcendence at the same time. It is argued that metaphysics through the space of culture allows us to empirically feel the universe as Unite, to assume the existence of meaning. The concept of metaphysics of culture as a sphere of philosophical research of the phenomenon of culture in its boundary, extra-experiential, essential principles of historical development and semantic transformations is defined. Based on the analysis, the author summarizes the definition of the phenomenon of culture as a specifically human way of mastering space and the conquest of time, and consciousness - as a topology of reflective practices.
Designing of electric vehicle with regenerative braking system
Authors: Ganesh S. , K. Vijay Nivas , Kavya A. , Arunteja S. , Guruvulunaidu P. , B. Ravi Kumar
Published: May 2023

India is the world's top producer of two-wheelers, which are frequently used in our daily lives. However, after a few years of service, the engine loses its efficiency and can no longer meet the environmental protection regulations. If these scooters could be transformed into electronic scooters, they could be used for a longer period of time. In this paper, an ordinary two-wheeled Honda Activa Scooter model powered by a two-stroke gasoline engine was converted into an electric vehicle. To increase efficiency, a novel approach known as regenerative braking was implemented. Regenerative braking temporarily conserves kinetic energy during deceleration and then uses it again as kinetic energy, thereby reducing fossil fuel consumption. When braking, a large amount of energy is typically lost as heat, but the regenerative braking system recovers this energy. With this system, the electric motor uses the vehicle's momentum to recover the energy lost while braking.
A review of the STATCOM device for improving wind farm stability
Authors: Neha Kushwaha , Simardeep Kaur
Published: May 2023

This review article presents an overview of the Static Synchronous Compensator (STATCOM) device, its working principle, and its application for improving the stability of wind farms. The article also highlights the importance of STATCOMs in enhancing the power quality of wind farms by improving voltage stability, reducing power fluctuations, and mitigating grid faults. Due to continuously fluctuating wind speeds and faults, the active power, reactive power, and terminal voltage are susceptible to continuous change, which applies to terminal voltage as well. When a STATCOM is connected to the grid, the active power, reactive power, and terminal voltage are maintained at the same level during the connection. This also contributes to an increase in the system's transient stability, which is an important consideration. The review further describes the modeling and control of STATCOMs, including the selection of appropriate control strategies for specific wind farm applications. Finally, the article concludes with a summary of the future research directions for the STATCOM device and its potential for integration into the smart grid.
INSTITUTIONALIZATION OF PROCESSES OF ECONOMIC SECURITY OF THE STATE AND SOVEREIGNTY OF THE COUNTRY
Authors:   Russian New University, Tambov branch, Chernova Veronika V. , Meshkova Lydmila L. ,   Russian New University, Tambov branch, Kozlov Arkady A. ,   Russian New University, Tambov branch
Published: May 2023

For Russia, whose goal is to ensure the protection of national economic interests and the formation of new international relations in the face of sanctions pressure, the issue of institutionally formed, both external and internal aspects of national security is the most important for ensuring national sovereignty. The article states that over the past thirty years, Russia has lost part of its sovereignty in the economic sphere, which negatively affected the state of its economic security. The situation in the sphere of economic security has aggravated under the conditions of sanctions, in connection with which today the country faces the task of institutional support for economic reforms. The author presents the main directions of reforming the Russian economy, which should create conditions for its further development, to ensure a sufficient level of economic security and to protect national sovereignty.
"GREEN" ENERGY AS A FACTOR OF THE EAEU SUSTAINABLE DEVELOPMENT: THE ROLE OF INTERNATIONAL LEGAL REGULATION
Authors:   MGIMO University, Pavlova Olga A. , Nazarova Aziza U. ,   MGIMO University
Published: May 2023

The «green» agenda and cross-border carbon regulation are placing high demand on ecology and efficiency across the entire value chain, from the extraction and processing of raw materials to logistics and supply of products to the end consumer. The scarcity of traditional energy sources forced a more conservative approach to the implementation of ESG principles and at the same time highlighted the need to diversify energy resources and form appropriate international legal regulation. The development of alternative energy is a long-term process that requires the timely creation of a regulatory framework both at the national and international levels. Nowadays, companies and countries are developing their projects and roadmaps for “green” energy, including the Eurasian Economic Union, but due to the fact that the direction is only developing, legislative regulation within the Union needs novelties and development of incentive mechanisms discussed and proposed in this article.
DESENVOLVIMENTO SUSTENTÁVEL E ANTROPOCENTRISMO
Authors: Marques José Roberto , Saraiva José Sérgio
Published: May 2023

A busca pelo desenvolvimento sustentável é meta da sociedade contemporânea, como forma de conciliar o direito ao meio ambiente ecologicamente equilibrado com o direito ao desenvolvimento. Este, quantitativamente ilimitado, não pode prejudicar as condições do ambiente propícias à sadia qualidade de vida, das presentes e futuras gerações, nem os direitos sociais. E o antropocentrismo é a posição que mais se ajusta a isso e à Constituição Federal.
CAMINHOS PARA A PROTEÇÃO DA LIBERDADE DE EXPRESSÃO: COMPREENDENDO A OBRA “FREE SPEECH: A HISTORY FROM SOCRATES TO SOCIAL MEDIA”, DE JACOB MCHANGAMA
Authors: Tito Bianca , Sá Mariana Oliveira de
Published: May 2023

A resenha apresenta as principais ideias da obra “Free Speech: A History From Socrates To Social Media”, de Jacob Mchangama (New York, Basic Books, 2022), com o objetivo de demonstrar o caminho histórico percorrido para a proteção da liberdade de expressão e de imprensa, bem como os desafios e entraves ocorridos ao longo deste trajeto.