bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydraulic Fracturing Designs for Low Permeability Gas Condensate Reservoirs Having Different Compositions
Authors:   , Mekmok Karanthakarn
Published: November 2023

Gas condensate reservoirs have been challenging all researchers in petroleum industry for decades because of their complexities in flow behavior. After dew point pressure is reached, gas condensate will drop liquid out and increase liquid saturation near wellbore vicinity creating production loss due to the phenomenon called condensate banking or condensate blockage. Many studies indicate the damage from condensate banking in many gas condensate fields all over the world and it can be more severe if the permeability of the reservoir is low. Hydraulic fracturing in horizontal well has been proved to be a reliable method to mitigate condensate banking and to increase productivity of condensate well by means of pressure redistribution in the near wellbore vicinity. In this work, compositional reservoir simulator had been implemented to study several designs of hydraulic fracturing in low permeability condensate reservoir. The objectives of this study are to study the effect of parameters of dimensionless fracture conductivity with different fluid compositions and saturation profile near wellbore vicinity had been observed. The results indicate that fracture width has impact on controlling inertial effect. Increasing fracture width improves condensate productions in both lean and rich condensate compositions to 18.45% and 12.15% compared to non-fracture case. While, higher number of fractures allow larger contact area between fracture and reservoir and increasing condensate production to 18.45% and 11.68% in lean and rich condensate compositions respectively. Moreover, number of fractures also plays an important role in the condition of having the same Stimulated Reservoir Volume (SRV). The investigation of fracture permeability shows small benefit from increasing fracture permeability from 50,000 mD to 150,000 mD because fracture permeability at 50,000 mD is already high enough compared to reservoir permeability at 0.2 mD. In addition, from the study of condensate saturation near wellbore indicates that condensate banking can be reduced effectively with the introduction of hydraulic fracturing. Especially in rich condensate composition where revaporization occurred. The couple effect of revaporization and hydraulic fracturing has benefit on decreasing condensate banking more than considering the effect of revaporization alone.
Formulation of silymarin nanoemulsions for dermal delivery
Authors:   , Charoenjittichai Ranit
Published: November 2023

Silymarin, a standardized extract from the seeds of Silybum marianum, has been used for liver diseases and recently it was reported to have many skin benefits including antioxidant, anti-tyrosinase, anti-inflammatory and antitumor. Delivery of silymarin through the skin has been an attractive as well as a challenging area for research. The present study aims to develop an optimal nanoemulsion containing silymarin using different surfactant mixture (smix) ratios and concentrations. Oil-in-water nanoemulsions were prepared by high-pressure homogenization method. Caprylic/capric triglycerides was used as an oil phase. Surfactant mixtures between Tween® 20 and Transcutol® were varied with different ratios and concentrations. Nanoemulsions were characterized for physical appearances, particle size and size distribution. Their physical stabilities were tested using centrifugation, heating-cooling cycle, and Ostwald ripening rate after storage at room temperature. The mean particle sizes of blank nanoemulsions were in the range of 88.3 to 227.2 nm with polydispersity index of 0.086 to 0.197. An increase in smix concentration resulted in smaller particle size. However, high Tween® 20, Transcutol®, or total smix concentration showed high Ostwald ripening rate and resulted in unstable nanoemulsions when stored in accelerated conditions. Nanoemulsion containing only Tween® 20 (F1 formulation) presented the lowest Ostwald ripening rate of 368.24 nm3/h and was selected. Carbopol® 940  (0.2 %w/w) was used as a gelling agent to improve the stability of nanoemulsion in heating-cooling cycles. 0.5 %w/w of silymarin was the maximum concentration that could be incorporated into nanoemulsion gel (SMNE gel). The particle size of SMNE gel was 112.7 nm with polydispersity index of 0.208. It showed good physical stability and passed six cycles of heating-cooling study. Consequently, silymarin content was 0.527 %w/w and gradually degraded during storage at 40 °C for three months. The entrapment efficiency of SMNE gel was 83.91 %. SMNE gel showed higher in vitro release of silymarin than silymarin microemulsion. The results supported our hypothesis that lower drug-system affinity in nanoemulsion which due to less surfactant should result in higher amount of silymarin released. For further studies, skin permeation of SMNE gel should be performed to compare with silymarin microemulsion, as well as skin irritation and its efficacy.
ALPHA-GLUCOSIDASE AND LIPASE INHIBITORS FROM DENDROBIUM FORMOSUM
Authors:   , Inthongkaew Prachyaporn
Published: November 2023

Phytochemical investigation of the methanol extract from Dendrobium formosum (Orchidaceae) resulted in the isolation of twelve known compounds, which included two phenanthrenes (confusarin, nudol), five dihydrophenanthrenes (hircinol, erianthridin, lusianthridin, coelonin, 2,5,7-trihydroxy-4-methoxy-9,10-dihydrophenanthrene), a dihydrophenanthrenequinone (5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone), three bibenzyls (gigantol, batatasin III, moscatilin), and a phenylpropanoid (dihydroconiferyl dihydro-p-coumarate). These structures were determined by analysis of their NMR and HRS-ESI-MS data. The isolates were evaluated for α-glucosidase and lipase inhibitory activities. Among the isolates, 5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone showed the highest α-glucosidase and lipase inhibitory effects with IC50 values of 126.88 µM and 69.45 µM, respectively. An enzyme kinetics study conducted by the Lineweaver-Burk plot method revealed that 5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone was a non-competitive inhibitor of α-glucosidase and lipase enzymes.
EFFECTS OF ZINC ION ON EPITHELIAL TO MESENCHYMAL TRANSITION AND CANCER STEMNESS OF LUNG CANCER CELLS
Authors:   , Ninsontia Chuanpit
Published: November 2023

Epithelial-to-mesenchymal transition (EMT) as well as cancer stem cells (CSCs) play critical roles in cancer progression and metastasis. Although these two events have distinct characteristics and molecular pathways, CSCs could be trigger during EMT process and CSCs were frequently found to possess EMT characteristics. Collective evidence showed that plasma level of zinc ion in the patients with lung cancer has significantly lower than that of normal subjects, suggesting the impact of zinc ion on the disease. Zinc ion implicates in many cellular processes and signaling of the cells; however, the regulatory role of zinc ion on EMT and CSCs are unknown. Herein, the present study has shown for the first time that zinc ion has converse effects on EMT and CSCs of lung cancer cells. While zinc ion enhances EMT phenotypes, it was shown to suppresses CSC program. For EMT, an increase in EMT markers including N-cadherin, vimentin, snail and slug and decrease of E-cadherin was observed in zinc ion-treated cells, indicating the induction of EMT with mesenchymal-like morphology and increased cancer cell motility. In contrast, zinc ion reduced tumor spheroid forming with the decreased expression of CSC markers (CD133 and ALDH1A1) and CSC transcription factors (Oct4, Nanog, and Sox2). For mechanistic approaches, zinc ion generated intracellular superoxide anion that increased the EMT proteins and promoted cell motility. Treatment with the specific superoxide anion inhibitor (MnTBAP) could reverse the effect of zinc ion on superoxide anion and EMT phenotypes. The decrease in tumor sphere formation and CSC markers in zinc ion-treated cells were also reversed by MnTBAP treatment. Moreover, this study found that superoxide anion generated by zinc ion suppressed CSCs through the PKCα/ß-catenin dependent mechanism by activating PKCα which subsequently phosphorylated and mediated ß-catenin degradation via the ubiquitin-proteasomal mechanism. Zinc ion has a capability to increase the ß-catenin-ubiquitin complex which can be blocked by bisindolylmaleimide I (PKC inhibitor). In conclusion, this current study has addressed the novel important regulatory roles of zinc ion and underlying mechanisms in regulation of EMT and CSCs, two major factors facilitating cancer aggressiveness. These findings lead to the better understanding of cancer cell biology regarding this essential endogenous element on cancer aggressive behaviors.
Effect of angelica dahurica extract on platelet aggregation in rat
Authors:   , Srisom Pitiphat
Published: November 2023

Kot Sor is one of Thai traditional medicine. It is used for improvement of circulatory system. The aims of this study were to investigate the effect of Angelica dahurica extract (ADE) on platelet aggregation, coagulation and gastric lesion in rat. From in vitro model, ADE at 1 mg/ml significantly inhibited ADP (5 µM)-induced platelet aggregation by 25.5±3.8 % (p<0.05) when compare with vehicle control. ADE inhibited COX-2 enzyme more potent than COX-1 enzyme with IC50 of 0.03 and 0.76 mg/ml, respectively. In vivo model, rats were treated with ADE 25, 50, 100 and 200 mg/kg orally for 7 days. ADE at 100, 200 mg/kg significantly inhibited ADP (5 µM)-induced platelet aggregation by 41.1±8.7% (p<0.001) and 45.1±8.9% (p<0.001) when compare with control group. The combination of ADE 200 mg/kg and ASA 80 mg/kg significantly inhibited ADP-induced platelet aggregation more than those treated with ASA alone by 84.7±8.6% vs. 47.0±11.3% (p<0.001). Moreover, the effects of ADE on coagulation parameters were evaluated by PT, aPTT and TT assays, all group of ADE did not affect to coagulation parameter. Finally, ADE did not change macroscopic morphology and pathohistology including submucosal edema, mucosal hemorrhage, epithelial cell loss and infiltration of inflammatory cell. In conclusion, Angelica dahurica extracts can inhibit ADP-induced rat platelet aggregation both in vitro and in vivo model. The mechanism of action may involve in the inhibition of COX-1 enzyme and ADP-induced pathway in platelets. ADE did not affect to coagulation parameter and gastric adverse effect. Moreover, the combination of ADE and ASA increase antiplatelet aggregation effect without increasing gastric lesion.
Effect of metformin on gene expression of multidrug resistance associated protein 2 (mrp2) in mcf-7 cells
Authors:   , Wannapakorn Ploy
Published: November 2023

Metformin is a biguanide anti-diabetic drug with various pharmacological activities including anti-carcinogenic action.  This study was to determine the effects of metformin on function and expression of MRP2 in human breast cancer MCF-7 cells.  The activity of MRP2 was assessed by measuring intracellular accumulation of CDCF fluorochrome.  The results showed that metformin had no direct effect on CDCF accumulation after 30-min treatment.  Prolong treatment of MCF-7 cells with metformin (1-5 mM) for 24-48 hr resulted in significant reduction of MRP2 mRNA levels, as measured by RT-PCR assay.  Metformin down-regulated expression of MRP2 mRNA in concentration-dependent manners.  Moreover, the cells treated with metformin (5 mM) had lower levels of phosphorylated ERK (p-ERK) and p38 (p-p38) than those of the control groups.  These results suggested that metformin could inhibit basal activities of ERK and p38 in the MAPK pathway.  The presence of an AMPK inhibitor compound C (10 µM) could prevent down-regulation of MRP2 mRNA as well as reduction of basal MAPK activities caused by metformin.  These findings suggested that metformin might decrease MRP2 mRNA expression in the MCF-7 cells via inhibition of MAPK signaling pathway.  The metformin-mediated alteration of MAPK signaling might relate to activation of AMPK pathway.  Further determination of MRP2 protein level in the metformin-treated cells should be pursued.
FLUORIDE RELEASE AND RECHARGE ABILITY OF RESIN-BASED SEALANT WITH BINARY ACTIVE FILLERS
Authors:   , Surintanasarn Atikom
Published: November 2023

This study was to evaluate the effects of different types of active filler in a resin-based pit and fissure sealant on fluoride release, recharge, and lactic acid neutralizing abilities. Mesoporous silica was synthesized from rice hull ash using sol-gel method. Resin-based sealant was incorporated with 5% w/w of the following fillers: calcium aluminate cement (CAC), synthesized mesoporous silica (SI), glass-ionomer powder (GIC), acetic acid-treated GIC (GICA), and combination of fillers. Resin-based sealant without filler added was the control. Ten specimens of each group were separately stored in 3 mL of deionized water and the fluoride concentration, before and after fluoride recharge with fluoride gel, were measured every 3 days (from day 3 to day 27). The lactic acid pH change after storage for 24 hours of specimens was measured. Zeta potential, particle size distribution, particle surface area (BET), and morphology of fillers were evaluated. The CAC and SI mixture (CAC+SI) group demonstrated the highest fluoride release after being recharged with fluoride gel. CAC:SI weight ratio of 1:1 and 2:1 showed higher fluoride recharge property than those of 1:2. The CAC+SI group also demonstrated increased lactic acid pH. These findings suggest that a resin-based sealant containing synthesized mesoporous silica and calcium aluminate cement may enhance remineralization due to fluoride recharge and higher pH.
THE INFLUENCE OF INTERMITTENT COMPRESSIVE FORCE ON OSTEOGENIC DIFFERENTIATION OF HUMAN MANDIBULAR-DERIVED OSTEOBLAST-LIKE CELLS
Authors:   , Sindhavajiva Pimrumpai
Published: November 2023

Mechanical force can regulate osteoblast differentiation in osteoblasts. Different types of force have different effects on osteoblasts. These effects are associated with the activation of purinergic receptors, especially purinergic 2X7 receptor (P2X7R). However, the molecular response of human osteoblasts to intermittent compressive force (ICF) associated with P2X7 receptors has not been clarified. ​In this study, the influence of ICF on human mandibular-derived osteoblast-like cells (hMOBs) was investigated. The role of ICF-induced ATP through P2X7R was examined. The hMOBs were obtained from non-pathologic mandibular bone. Cells were subjected to ICF for 20 h. The hMOBs were cultured in osteogenic medium in the absence or presence of 0.5-5 µM 2’(3’)-O-(4-benzoyl) benzoyl-ATP (BzATP), a selective P2X7R agonist. The mRNA expression was investigated by quantitative real time polymerase chain reaction. In vitro mineral deposition was investigated by Alizarin Red S staining. Transfection of small interfering RNA was performed to confirm the effect of P2X7R activation. WNT/β-catenin signaling was detected by immunofluorescence staining for β-catenin. The results demonstrated that ICF increased the OSX and ALP mRNA expression and enhanced in vitro mineralization. In addition, WNT3A mRNA expression and β-catenin nuclear translocation were also increased. These effects were related to ICF-induced ATP. However, BzATP significantly attenuated in vitro mineralization and RUNX2 and OSX mRNA expression in osteogenic medium-induced hMOBs. Knockdown P2X7R expression by siRNA rescued BzATP-inhibited RUNX2 and OSX expression. Interestingly, a reduction of WNT3A mRNA expression and blockage of osteogenic medium-induced β-catenin nuclear translocation were also found in BzATP treated group. The addition of recombinant human WNT3A abolished the effect of BzATP-reduced osteogenic marker gene expression and in vitro mineralization. In conclusion, our results demonstrated that ICF-induced ATP enhanced osteoblast differentiation and WNT/β-catenin signaling pathway. P2X7R pathway participates in BzATP-inhibited osteoblast differentiation of hMOBs. This inhibitory effect was associated with inhibition of the WNT/β-catenin signaling pathway.
The Physical Properties Of Auto-Polymerizing Hard Denture Relining Materials After Ultrasonical Cleaned With Ethanol Solutions
Authors:   , Soontornwipath Sutasinee
Published: November 2023

Hard reline resin materials are commonly used to improve the fit of denture bases caused from resorption of the residual alveolar ridge. Major problem of resin is the presence of residual monomer after polymerization which had an adverse effect on the toxic and physical properties of the reline resin. Ethanol solutions in ultrasonic cleaner used been proven to reduce the residual monomer effectively in auto-polymerizing hard reline resins. The purpose of this study was to evaluate the flexural strength, flexural modulus, surface hardness, water sorption, and water solubility of four auto-polymerizing hard reline resins [Unifast Trad (UT), Kooliner (KL), Ufi Gel Hard (UG), and Tukuso Rebase II (TR)] after ultrasonic treatment with difference ethanol concentrations. For each material, ninety specimens were prepared and divided into 9 groups: negative control (NC): no treatment, positive controls: treated by immersion in water at 50°C for 1 hour (PC1), immersion in water at 55°C for 10 minutes (PC2) and the ultrasonic group, treated by immersion in 0%, 10%, 20%, 30%, 40% or 50% ethanol solution at 55°C for 5 minutes. The flexural strength and flexural modulus were determined using a three point transverse test. After that, one fragment of each specimen was analyzed using the Vickers microhardness test. The water sorption and solubility tests were performed per ISO No.20795-1. The data were analyzed by one-way ANOVA, Tukey's test, and Dunnett's test at a 95% confidence level. The results demonstrated significant differences in the level of flexural strength, flexural modulus, water sorption, and water solubility between the groups (p<0.05) within each specific auto-polymerizing hard reline resin, whereas there is no significant differences in the level of surface hardness between the groups of each specific material (p>0.05). Comparing in four types of auto-polymerizing hard reline resin after the same treatment method showed significant differences in level of flexural strength, flexural modulus, surface hardness, water sorption, and water solubility (p<0.05). UT demonstrated significantly higher flexural strength, flexural modulus, surface hardness, and water sorption than the other hard reline resins, whereas TR showed significantly higher water solubility than other materials. In conclusion, for KL, the 10% ethanol solution in ultrasonic cleaner should be the treatment of choice which effectively increases the physical properties. In UG and TR, the 10% ethanol solution in ultrasonic cleaner maintained the physical properties. In UT, the 30% ethanol solution in ultrasonic cleaner had appropriate physical properties.
Reducing metabolic syndrome among particular at risk female workers by using peer-led intervention in uniform-sewing military factory Bangkok metropolitan region Thailand
Authors:   , Sanee Aree
Published: November 2023

Metabolic Syndrome (MetS) is a major health problem in Thailand. Females are reported to have a higher rate of MetS than males. Very few peer-led intervention studies have been conducted on specific groups, such as seamstresses, at risk of MetS. This study aimed to evaluate the effect of a peer-led intervention program on reducing MetS in female workers in Thai Uniform-Sewing Military Factories. A quasi-experimental design was applied to female sewing factory workers selected for this research. All participants had MetS with at least one of the following; 1) waist circumference > 80 cm 2) raised triglyceride levels 3) reduced HDL cholesterol 4) raised blood pressure 5) raised fasting plasma glucose.  But while the experimental group (N=50 participants) received individual and group support discussion sessions that included both dietary and physical activity advice, including group activities for sharing experiences and supporting to each other, the control group (N=49 participants) followed their usual daily routines.  Data were analyzed using  repeated measures ANOVA. The results showed that after six months of participation, when compared to the control group, the intervention group had significantly improved in clinical parameters (triglyceride, High Density Lipoprotein) and knowledge of MetS. In addition, there were significant differences in waist circumference, body mass index, systolic blood pressure, diastolic blood pressure as well as prception of MetS and risk factors and physical activity (PA) were the significant differences of the intervention group. However, fasting plasma glucose, food frequency score and stress levels were not significantly different but still improved. Findings from this study suggest that a peer-led support program could be introduced as an effective means of improving the behaviors of mostly sedentary factory workers at risk of MS or other health risks caused by working habits that are detrimental to health.
The effect of Angklung (Ang-Ka-Lung) intervention model for improving the quality of life among elderly people in Maung District, Samutprakarn Province, Thailand
Authors:   , Wattanasoei Supang
Published: November 2023

Thailand is nowadays facing the rapidly growing population of the older person. Many of Thai elderly people have been found that they are living at homes alone and inactive affecting their quality of life (QOL). Music activities can help improve the quality of life by facilitating and stimulating the elderly to be active with the non-verbal expression of emotional and physical aspects. This study aims to evaluate the effects of Angklung intervention model on the quality of life among elderly people in Samutprakarn province, Thailand.This study was a quasi–experimental study with the control group. The 118 elderly people were assigned into two groups, which were 59 elderly living in Maung district, Samutprakarn province for the intervention group and 59 elderly living in Bangpakong district, Chacheongsao province for control group. The Angklung intervention was conducted and the activities took 2 hours per day once a week for 8 weeks. Data were collected at baseline (T1), 8th week (T2), 12th week (T3), and 16th (T4) after the intervention implemented. The quality of life was measured by WHOQOL-OLD. General Linear Model repeated-measures ANOVA and ANCOVA were used to assess the mean difference between groups and within group overtimes.The overall quality of life after implemented Angklung intervention model significantly increased in the intervention group compared with the control group. When divided the quality of life into 6 facets: the sensory Abilities (SAB), autonomy (AUT), past, present, and future activities (PPF), social participation (SOP), death and dying (DAD), and intimacy (INT), there were also statistical differences (p-value < 0.05). The results from General Linear Model repeated-measures ANCOVA was shown that the total quality of life (QOL) was different after the intervention with statistically significant (p-value < 0.01). When considering each facets of QOL, all facets were significantly different (p-value < 0.01). This study provides an overview of music activity role in improving the quality of life among the elderly and can be the guideline in being engaged in music activities that can help the elderly connect their life experiences with other people. Consequently, music activity can be considered for applying and developing as the simple and cost-effective intervention for improving the quality of life in the elderly community further for the other settings.
HIV/AIDS KNOWLEDGE, ATTITUDES AND PRACTICES AMONG WOMEN IN SOUTH SUDAN: SECONDARY DATA ANALYSIS - MULTIPLE INDICATOR CLUSTER SURVEY 2010.
Authors:   , Minchoul Boumkouth
Published: November 2023

HIV/AIDS Knowledge, attitude and practice are basic foundation of prevention and control of AIDS disease at individual and general population level. This study was aimed to assess level of knowledge, attitudes and practices regarding HIV/AIDS and factors associated. Study was secondary data analysis based on the UNICEF MICS (multiple indicator cluster survey) of 2010 for South Sudan. Data from 9069 participants were used. Descriptive statistic was used to describe number, percentage, and level of knowledge, attitudes and practices. Binary logistic regression was used to assess association between independent and dependent variables. 46.0% of respondents had never ever heard about AIDS disease, and misconception about transmission methods was observed. Knowledge level regarding HIV/AIDS was low among study group where 63.1% of them were having low knowledge.72.4% of participants expressed negative attitudes toward people living with HIV/AIDS. Factors associated with safe practices were urban area( OR = 1.6, 95% CI =(1.12-2.17), education level (OR = 1.9, 4.4, 5.3, 95% CI = (1.3-2.8), (2.8-7.0) and (1.4 -19.4), marital status (former married) OR = 1.33, 95%CI = (0.84 -2.1), wealth index levels OR = 1.2, 95% CI = (0.47 – 3.2) , 1.6, 95% CI= (0.61 -3.5), 1.7 , 95% CI =(0.77 – 4.0) and 1.9, 95% CI (0.85 – 4.5), and attitude OR = 1.8 , 95% CI (1.3 – 2.5) and P-value = <0.01.Factors associated with high/moderate knowledge level were residence area (OR = 1.3 95% CI (1.1 -1.4), Education level (OR = 1.6, 95% CI = (1.2 – 1.5), 2.6 95% CI = (1.1 – 6.9), wealth index( OR = 1.2, 95% CI (0.94 – 1.6) , 1.3, 95% CI =(1.0 – 1.7), 1.4, 95% CI = (1.1 -1.8) , 1.5, 95% CI =(1.2 -2.0). and attitude( OR = 1.5, 95% CI =( 1.3 – 1.96) . P-value was < 0.01. Positive attitudes were associated with, residence area(OR = 1.5, 95% CI =(1.3 – 1.7), education level ( OR = 1.7, 95% CI (1.4 – 1.9), 3.1 95% CI (2.4 – 4.0) , 1.6, 95% CI (0.6 – 4.2), former married (OR = 1.4 , 95% CI (1.1 – 1.8), wealth index(OR = 1.4, 95% CI(1.0 – 2.0) , 2.0, 95% CI(1.5 – 2.7), 2.2, 95% CI(1.7 – 3.0), 2.5, 95% CI(1.9 – 3.4) , practices( OR = 1.8, 95% CI (1.3 – 2.5) and knowledge level(OR = 1.5, 95% CI(1.3 – 1.7) . P-value was < 0.01. Majority of study group were having low knowledge of HIV/AIDS, and negative attitude and risky practices. Therefore, policy and intervention reinforcement is needed.
HEALTHCARE PROVIDERS’ KNOWLEDGE AND PERCEPTION IN THE PROVISION OF PALLIATIVE CARE IN PATIENTS WITH NON-CANCER LIFE-LIMITING CHRONIC DISEASE IN A PRIVATE HOSPITAL IN BANGKOK,THAILAND
Authors:   , Prachyakoon Numpueng
Published: November 2023

Although palliative care could gain benefits of healthcare system, the good management of palliative care is not broadly done to all kinds of illnesses. Patients with chronic illness have impaired quality of life and emotional well-being but have less obtainment of palliative care. This study aimed to access the knowledge, perception and provision of palliative care in patients with non-cancer, chronic-illness and life-limiting diseases and to explore the socio demographic factors associate to knowledge and provision of palliative care. This cross-sectional descriptive study was conducted in one selected private hospital. 227 healthcare providers including doctors, nurses, pharmacists and physical therapists were recruited, self-administration questionnaires were used for data collection. For the results of palliative care knowledge, the questionnaire contains 23 items about the principle of palliative care and symptom management. The participants had good knowledge (x̅ = 18.97, S.D. =2.11, Min =8, Max =23). Almost half of the participants (49.1%) had answered incorrectly about palliative care in patients with congestive heart. The factors of healthcare providers’ demography that associate to to the level of palliative care knowledge statistical significantly were age (p= 0.04) and position of work (p =0.001) (p < 0.05). In their perception, the aspects that had the most effect to palliative care were ethic and legal issues (x̅ = 4.18, S.D. = 0.648) and organization and policy (x̅ = 4.17, S.D. = 0.584). They also mainly agreed that palliative care should be provided by multidisciplinary care team (x̅ = 4.35, S.D. =0.622). For the perception of decision making, the participants mainly agreed that palliative care should have jointly established between patients and family and healthcare team (x̅ = 4.37, S.D. = 0.583). For the provision of palliative care, the behavior that healthcare providers mainly performed is providing care gently (x̅ =4.48, S.D. = 0.693) but had less conversation about the aims of life and the life after death with patient (x̅ =2.80, S.D. =1.350). For the factors of healthcare providers’ demography that associate the level of provision of palliative care statistical significantly were position of work (p = 0.029) and palliative care education (p =0.002) (p < 0.05). It could be concluded that palliative care knowledge, cooperation of multidisciplinary care team and training palliative care skill are important for healthcare providers to cope with the patients and families. It is to explore needs and plan for goal of care and provide the best quality of palliative care for them.
OCCUPATIONAL EXPOSURES AND HEALTH HAZARDS IN PARA RUBBER WOOD SAWMILLS IN TRANG PROVINCE, THAILAND
Authors:   , Thepaksorn Phayong
Published: November 2023

Objectives: The aims of this study were 1) to identify Job safety analysis (JSA) and hazard identification for occupational health risk exposures and health hazards for work accident prevention in Para rubber wood sawmills and 2) to assess the associations between respiratory symptoms and pulmonary defects of Para rubber sawmill workers. Materials and Methods: A cross-sectional study was conducted, including a walk-through survey, JSA and personal and environmental wood dust and noise samplings, pulmonary function and spirometry tests between October 2015 and February 28, 2016 at 4 Para rubber wood sawmills in Trang Province. In totall, 687 Para rubber sawmill workers were participating from four sawmills completed questionnaire interviews, and a subset of sawmill workers from four factories participated in spirometric measurements and personal dust samplings. Logistic regression analysis was used to explore risk factors for pulmonary impairments. Results and Discussion: Potential occupational safety and health hazards associated with six main processes had been evaluated, including logging and cutting, sawing the lumber into sheets, plaining and re-arranging, vacuuming and wood preservation, drying and planks re-arranging, and grading, packing, and storing. JSA and hazard identification on working process in sawmills showed high risk levels of wood dust and noise exposure, occupational accidents on hands and feet, chemicals and fungicide exposure and ergonomics or repetitive works. The workers exposed highest noise levels at sawing department(Median=92.7 dBA).The exposed workers had higher in respirable wood dust exposure (0.902mg/m3) compared with the unexposed groups (0.185 mg/m3). The exposed group had significantly higher prevalence than the unexposed group for chest tightness (OR = 2.79; p=0.01) and shortness of breath (OR = 2.27; p=0.04). The ventilatory function values (FEV1 and FVC) were lower for the exposed group compared with the unexposed group (2.41 Vs 2.55 L/s and 2.91 Vs 3.01 L/s, respectively). Results suggest that the sawmills should implement appropriate exposure control measures to reduce wood dust and noise exposure. The authors recommended the administrative controls and engineering controls for minimizing possible accidents and hazardous exposures. All sawmill workers were strongly recommended to use personal protective equipment in any working processes.
Do Indonesia Islamic Banks Perform Better Than Malaysia? A Malmquist Index Approach
Authors: Uula Mimma Maripatul , Rusydiana Aam Slamet , Ali Mohammad Mahbubi
Published: November 2023

This study aims to measure the productivity of Islamic banks in Indonesia and Malaysia using the Malmquist Productivity Index (MPI) method with the research period 2010-2019. The research objects used are 23 Islamic banks in Indonesia and Malaysia. The data of this study comes from the annual financial statements of each bank from the period 2010-2019. The input variables in this study are employee costs, administrative costs and third-party funds. And for the output variable is financing and operating income. The results of this study explain that during the period 2010-2019, the productivity level of Islamic banks in Indonesia and Malaysia has a fluctuating trend from year to year. Based on the average TFPCH score, it is concluded that the productivity of Islamic banks shows no increase in productivity or constant and technological change has not contributed optimally to the increase in productivity of Islamic banks in Indonesia and Malaysia. Furthermore, analyzing individually on Islamic Banks in Indonesia and Malaysia, it is found that there are 8 Islamic Banks with increased productivity, one Islamic bank in Malaysia and seven Islamic banks in Indonesia. The results also highlighted that the productivity level of Islamic banks in Indonesia is relatively better than Islamic banks in Malaysia.  Then, the Malmquist Index quadrant analysis found that Islamic Banks in Indonesia and Malaysia dominate in quadrant 3 with a total of 12 Islamic Banks, followed by quadrant 4 with a total of 7 Islamic banks, and quadrant 1 with a total of 4 Islamic banks.
ANALISIS PROSEDUR DAN KETENTUAN UMUM DALAM PEMBUATAN VISUM ET REPERTUM TAHUN 2022
Authors: Suyoko Suyoko , Nabila Azahra Alya , Putri Amable Firliana , Fadilah Utami Rahma , Nurkhaliza Rosiyana
Published: November 2023

Dalam mengejar keadilan, penyelidik memiliki wewenang untuk memulai permintaan Visum et Repertum sebagai bahan bukti dengan signifikansi hukum substansial yang diperoleh melalui prosedur, desain, dan format khusus. Penelitian ini secara komprehensif menganalisis penciptaan Visum et Repertum, dengan penekanan utama pada seluk-beluk prosedural dan keselarasan dengan ketentuan yang telah ditentukan. Dalam penelitian deskriptif kualitatif ini, wawancara dan observasi dilakukan di empat fasilitas medis berbeda pada Juni 2022: RSUD Dr. Asmir Salatiga, RS Jenderal Ahmad Yani Metro Lampung, Hj. Anna Lasmanah Banjarnegara, dan RS Majenang. Informan adalah mereka yang ditugaskan untuk membuat Visum et Repertum. Analisis data selanjutnya dilakukan melalui teknik deskriptif. Temuan mengungkapkan variasi dalam prosedur Visum et Repertum di seluruh rumah sakit meskipun berakar dari kerangka teoritis yang sama. Beberapa rumah sakit menghilangkan rincian mengenai tingkat peringkat yang diizinkan dari penyelidik yang berwenang untuk meminta Visum et Repertum. Kepatuhan terhadap ketentuan umum Visum et Repertum mencapai 100%. Namun, masih ada kebutuhan untuk membuat peraturan yang tepat dalam kebijakan rumah sakit, terutama dalam hal menetapkan kualifikasi pangkat personel penegak hukum yang memenuhi syarat untuk meminta Visum et Repertum.
THE IMPACT OF TRAINING AND ORGANIZATIONAL CULTURE ON EMPLOYEE PERFORMANCE THROUGH EMPLOYEE ENGAGEMENT AS AN INTERVENING VARIABLE IN PT TELKOM AKSES
Authors: Hamam Syifaul
Published: November 2023

The title of this research is the impact of  training and organizational culture on employee performance through employee engagement as an intervening variable in PT Telkom Akses Yogyakarta. The study aims to determine the influence of employee engagement mediation in the relationship between organizational culture and training on employee performance. This research is performed quantitatively and uses questionnaires as data collection methods. Population of 339 employees. Research samples used as much as 80 employees. Therefore, sampling uses the slovin’s formula method. Methods of research analysis using T-Test, simple and multiple linear regression analysis. The results showed that training and organizational culture were positively and significantly influential for employee engagement, training and organizational culture were positively and significantly impacted by employee performance. There is a significant mediation influence from employee engagement in organizational cultural relationships to employee performance. There is a significant mediation influence of employee engagement on the training relationship to the employee's performance.
GAMBARAN UMUR IBU DAN JUMLAH PARITAS PADA KASUS ABORTUS DI RSKIA UMMI KHASANAH BANTUL TAHUN 2022
Authors: Rikhanis Harista , Azka Arlina , Ashari Mochamad Any
Published: November 2023

Masalah kesehatan ibu merupakan masalah yang perlu mendapatkan prioritas utama. Salah satu masalah kesehatan adalah tingginya angka kematian ibu (AKI). Hampir 95% dari semua kematian ibu terjadi di negara berpenghasilan rendah dan menengah pada tahun 2020. Abortus sebagai salah satu penyebab kematian ibu merupakan masalah yang sangat membutuhkan perhatian. WHO memperkirakan sebesar 15-50% kematian ibu berkaitan dengan abortus. Beberapa faktor risiko terjadinya abortus adalah umur ibu dan juga jumlah paritas. Untuk mengetahui gambaran usia ibu dan jumlah paritas pada kasus abortus di RSKIA Ummi   Khasanah tahun 2022. Penelitian ini menggunakan metode deskriptif dengan pendekatan cross-sectional. Populasi dalam penelitian ini adalah seluruh ibu bersalin di RSKIA Ummi Khasanah di tahun 2022 sebanyak 359 orang. Pengambilan sampel dilakukan dengan teknik non-probability sampling. Instrument yang digunakan adalah rekam medis. Analisis data yang digunakan yaitu analisis univariat dengan bantuan software SPSS. Mayoritas ibu hamil yang mengalami abortus berdasarkan umur adalah ibu yang berusia 20-34 tahun yaitu 48 orang (58.50%), menurut paritas adalah kelompok nullipara yaitu 34 orang (41.50%). Dan sebagian besar adalah abortus karena blighted ovum yaitu 36 orang (43.90%). Mayoritas ibu yang mengalami abortus berusia antara 20-34 tahun, yaitu sebanyak 48 (58.50%), ibu dengan nullipara yaitu 34 orang (41.50%) dan dengan abortus yang dikarenakan blighted ovum, yaitu 36 orang (43.90%).
Perlindungan dan Permasalahan Hukum Bagi Pemegang Hak Paten di Indonesia
Authors: Indarinul Mufidah Luluk , Saini Mukhamat
Published: November 2023

Indonesia merupakan negara yang memiliki kekayaan sumber daya genetik dan pengetahuan tradisional yang sering dimanfaatkan oleh Inventor dalam dan luar negeri untuk menghasilkan Invensi yang baru,  oleh karena itu, dalam undang-undang ini terdapat pengaturan mengenai penyebutan secara jelas dan jujur bahan yang digunakan dalam Invensi jika berkaitan dan/atau berasal dari sumber daya genetik dan/atau pengetahlan tradisional tersebut dalam deskripsi. Indonesia sebagai negara hukum telah berupaya untuk melindungi inventor atas invensinya dengan berbagai formula regulasi hukum positif berupa perundang-undangan dan beberapa peraturan, namun demikian masih terdapat beberapa problematika yang perlu diselesaikan, diantaranya masih rendahnya literasi masyarkat terhadap hukum Paten, terdapatnya klausa hukum yang kontradiktif dan mulitafsir.
Jane Dieulafoy in Varamin: The Emamzadeh Yahya through a Nineteenth-Century Lens
Authors: Overton Keelan
Published: November 2023

This article explores the condition and reception of Varamin’s architectural heritage from the Ilkhanid period (1256–1353) during the late nineteenth century. I use two relatively untapped sources: the photographs of French traveler Jane Dieulafoy (1851–1916) and the account of Qajar statesman E‘temad al-Saltaneh (1843–96). Reading these sources in tandem paints a robust picture of Varamin when it was becoming known for luster tilework and its Emamzadeh Yahya tomb complex was being steadily plundered. While our travelers captured a seminal moment in Varamin’s history, this study ultimately moves beyond their frames and encourages a present-day appreciation of the city’s still standing monuments.
The Perpetual Unfolding of Photographic History: A Previously Unknown Panorama of Salvador, Bahia, by Rodolpho Lindemann
Authors: Pestarino Julieta
Published: November 2023

This article examines a panoramic photograph of the Brazilian city of Salvador, in the state of Bahia, taken around 1880 by Rodolpho Lindemann. Recently added to the collection of the Getty Research Institute, this large six-part folding work has not been mentioned in previous studies or in the foremost books on the history of photography in Brazil, suggesting that its existence has not been widely known. Although it bears no signature or stamp, comparison with a drawing based on the photograph made it possible to determine its authorship. This article explores connections with other panoramic images produced in the country in order to propose a framework for thinking about the representation of landscapes and cities according to the panoramic tradition, as well as the question of unknown authorship in photography.
Constitutionalizing the right to abortion is not political opportunism
Authors: Geiger Sarah
Published: November 2023

Recently, Baptiste Charvin wrote on this blog that the right to abortion has become the subject of political instrumentalization in France. In his view, it illustrates a general phenomenon of 'constitutional desacralization' and underlines the division the French people are experiencing, 'despite being governed by a Constitution that enshrines a set of values that should be shared by all.' I argue that the French parliamentary debate on the right to abortion is anything but a phenomenon of recent political opportunism. Instead, it reflects – for once – a majority opinion, not the division of French society.
Identifying Trends of Policy Transfer Practices in Indonesia: A Systematic Literature Review (2012 - 2022)
Authors: Yuniar Sani Sofia , Fathurrahman Reza
Published: November 2023

The practice of policy transfer has been known since 315 BC, but conceptually it has been increasingly discussed by policy experts in the world in the last 30 years. In the Indonesian context, the application of policy transfers has been increasingly adopted by policymakers in the last ten years or so. In practice, policy transfer is an alternative that makes it easier for policymakers to make new policies. Policy transfer facilitates learning of good policy practices from various initiating countries so as to minimize failure. The transfer process is easier to build when a network or relationship is established between the actors acting as the source of the transfer, the recipient of the transfer, or other related parties. This study analyzes the implementation of policy transfers that have occurred in Indonesia in the last ten years (2012-2022) through 4 stages of Systematic Literature Review, namely 1) Pre-SLR; 2) Identification, 3) Screening, and 4) Eligibility. There were 31 selected publications which were further analyzed based on three criteria: 1) Fields/areas where policy transfer was applied, 2) Research methods conducted, and 3) Policy transfer analysis. Topics related to the analysis of policy transfers produce 5 sub-topics that can be studied further, namely: Transfer products, Transfer Loci, Policy Actors, Forms of Transfers, and Transfer Processes
Culinary Heritage as Tourist Attraction in Kota Tua, Padang-West Sumatera
Authors: Sekar Sari Melati , Widyatmaja I Gusti Ngurah , Yanthy I Putu Sucita
Published: November 2023

This research examines the culinary heritage in the Kota Tua area as one of the Integrated Tourism Areas in Padang City. This area is enriched with historical buildings and culinary influenced by various ethnicities that have been around for decades. However, culinary tourism development in this area is relatively slow because of a lack of active collaboration between stakeholders. This research aims to analyze the potential and obstacles to developing culinary heritage as a tourist attraction in the Kota Tua of Padang. This study used a descriptive qualitative method. The data collection technique used was in-depth interviews with stakeholders. The data taken was processed and analyzed using thematic analysis techniques. The results of this research show the importance of an effective development of culinary tourism as a tourist attraction in Kota Tua, Padang. In developing this area as a tourist attraction, it is formulated from thematic elements of stakeholder statements during interviews. These elements indicate development strategies in accordance with the potential and obstacles experienced during the process of developing culinary tourism as a tourist attraction. In an effort to overcome the issue of developing culinary tourism as a tourist attraction in Kota Tua, Padang requires the holistic involvement of relevant stakeholders in producing regional development through historical narratives regarding culinary products and storytelling as well as events such as the Culinary Tourism Festival.
Analysis of the Effect of Leadership Style, Financial Rewards and Work Environment on Turnover Intention Mediated by Job Satisfaction (Empirical Study: Private Bank Jakarta Employees)
Authors: Thu Suwandy , Widhianto Chandra Wibowo
Published: November 2023

This study aimed to investigate the impact of leadership style, financial rewards, and work environment on turnover intention, with job satisfaction as a mediating factor among employees of private Bank/Bank BDI Jakarta. The research adopted a quantitative approach with hypothesis testing, collecting primary data through valid questionnaires filled out by 330 respondents, specifically employees of Bank  BDI, using Stratified Sampling. Data analysis was conducted using Structural Equation Model (SEM) with Smart PLS software version 3.0. The findings indicate a positive and significant influence of leadership style, financial rewards, and work environment on turnover intention, mediated by job satisfaction among Bank BDI Jakarta employees. However, the direct testing of leadership style, financial rewards, and work environment did not demonstrate a significant impact on turnover intention, suggesting the presence of other significant factors influencing turnover intention beyond the three independent variables examined. In conclusion, job satisfaction plays a pivotal role in determining turnover intention, and enhancing job satisfaction can effectively reduce turnover rates among Bank BDI Jakarta employees. However, it's worth noting that this study's limitation lies in its sample being limited to Jakarta, making it difficult to generalize the findings to all branch offices due to potential variations in characteristics and cultures across different regions.
The Organization of Negative Business Messages Preferred by Students in Higher Education
Authors: Wijayanti Sri Hapsari
Published: November 2023

Written communication in an educational setting aims to convey messages related to academics or finances. The messages delivered contain either positive or negative information. This study aims to reveal the organization of negative business messages preferred by higher education students while receiving messages from university parties. The participants are the vice-chancellors for finance and academic affairs or the representatives (heads of divisions) at three private universities within the Association of Catholic Higher Learning Institutions as the senders and 170 active students in several universities as the receivers. This study uses quantitative and qualitative descriptive approaches. I collected data through online questionnaires, semistructured interviews, and observation of written documents in email and WhatsApp. I proposed four essential dimensions of negative message, namely, organization/approach, language, medium, and response, with the Likert scale questionnaire. I also inserted two cases of negative messages at the end of the questionnaire to find students’ tendency to select one they liked. The questionnaire results are used to discover the participants’ preference for the approach of relaying negative messages, corroborated by the interviews. The study found that students preferred direct approach to negative business messages. Buffers, prevalent in negative business with indirect order, are found in the email. A positive tone was not found at the end of the message. The study concluded that negative messages should be conveyed in writing with direct organizations and positive language and addressed to students before being forwarded to their parents