bluuebunny/crossref_metadata_2025 huggingface dataset:
PLANEAMIENTO ESTRATÉGICO EN EL SECTOR PÚBLICO
Authors: Cabrejos Burga Dr. Raul
Published: November 2017

La implementación del Planeamiento Estratégico en las organizaciones del estado de los países de América Latina, se origina en el programa “Alianza para el Progreso” creada por iniciativa del Ex Presidente de EEUU, J.F. Kennedy, como una herramienta para contrarrestar la influencia de la Revolución Cubana y apoyar medidas reformistas para el desarrollo económico y social. Este programa fue aprobado en el año 61, en una reunión organizada  por el Consejo Interamericano Económico de la Pera (CIE) en Punta del Este (Uruguay) donde asisten todos los países que integraban esta organización, incluyendo Cuba quien fue el país que no aprueba la declaración y carta en la cual se establece que Estados Unidos, proporciona apoyo económico a los países de América Latina, siempre que estos cumplan con formular sus planes decanales, la modernización de la industria, la reforma agraria y otras medidas.
CADENAS DE SUMINISTRO Y ESTRATEGIAS DE CRECIMIENTO PARA LAS PYMES DE LA REGIÓN AYACUCHO / SUPPLY CHAINS AND GROWTH STRATEGIES FOR THE SMES AT THE AYACUCHO REGION
Authors: Oré Gutierrez Dr. Eusterio
Published: November 2017

RESUMENLos principales problemas en la logística de abastecimiento de las PYMES de la Región Ayacucho son el control y manejo de los inventarios, el deficiente almacenamiento y la carencia de sistemas  de información. Adicionalmente, inciden otras características productivas del sector y que en parte  explican el bajo grado de desarrollo en la Industria. Objetivos: Determinar las variables que afectan a las PYMES de la Región Ayacucho en su integración a cadenas de suministro como factor clave  para establecer estrategias de crecimiento. Tipo de investigación: Aplicada. Metodología: Inductiva-deductiva. Diseño  descriptivo-correlacional. Población: 120 empresas formalmente constituidas en  el año 2012; para recolectar datos utilizamos un cuestionario autoadministrado; en el análisis empleamos   la estadística descriptiva. Resultados: La cadena de suministros en los aspectos identificados como dimensiones de cada una de las variables de estudio, constituyen estratégias de crecimiento para las  PyMES de la Región Ayacucho. PALABRAS CLAVES: Cadena de suministros, estrategia de crecimiento.ABSTRACTThe principal problems in the logistics supply of the SMEs at the Ayacucho region are the inventories control and management , the deficient storage and the lack of information systems.  In addition, there affect other productive characteristics of the sector  that partly explain the low degree  of industry development. Aims: To determine the variables that  affect  the SMEs at  the  Ayacucho Region in its integration to supply chains  as a key factor to establish growth strategies. Design : Descriptive - correlational.  Population: 120 companies formally constituted in the year 2012;  we  applied administered questionnaire to collect information; we applied the descriptive statistics in the analysis step. Results: The  supply chain, in the aspects identified as dimensions of each studied variable, constitutes growth strategies for the SMEs at the  Ayacucho region.Key words : supply chain, growth strategy
INFLUENCIA DEL CURSO DE LÓGICA EN EL DESARROLLO DE COMPETENCIAS GERENCIALES / THE IMPACT OF LOGIC STUDIES IN DEVELOPING MANAGEMENT SKILLS
Authors: Katayama Omura Dr. Roberto
Published: November 2017

RESUMENUn elemento clave en la educación del futuro administrador es el desarrollo de competencias gerenciales  para una toma de decisiones apropiada, lo que supone un razonamiento correcto. La Lógica tiene como objetivo el determinar la corrección de los razonamientos. Por ello, en el presente artículo  se estudia la contribución de la lógica en el desarrollo de competencias gerenciales en los alumnos  del primer ciclo de la Escuela de Administración y Negocios Internacionales de la Universidad Alas  Peruanas.Palabra clave: Lógica, competencias gerenciales.ABSTRACTA key factor in  the future manager’s education  is developing management skills in order to take suitable decisions, this ability requires right inferences. The main target of Logic is determining what is a right inference. Therefore, in this article we study the  impact of logic studies in developing management skills in students of the Management and International Business School  at Alas Peruanas University .Key words: Logic, management skills.
CLIMA ORGANIZACIONAL Y SATISFACCIÓN LABORAL DE LOS DOCENTES DE LA RED N° 11 DE CONDEVILLA EN EL DISTRITO DE SAN MARTIN DE PORRES. 2013./ORGANIZATIONAL CLIMATE AND JOB SATISFACTION OF TEACHERS IN THE NETWORK CONDEVILLA IN THE DISTRICT OF SAN MARTÍN DE PO
Authors: Mascco Padilla Mg. Julio Marcial
Published: November 2017

RESUMENEl objetivo general del estudio fue determinar la relación que existe entre el clima organizacional y la satisfacción laboral de los docentes de la Red N° 11 de Condevilla en San Martín de Porres. 2013.La población estaba conformada por 300 docentes, siendo la muestra escogida de 171 docentes. Los datos fueron recogidos mediante encuestas validadas a nivel nacional por la Psicóloga Sonia Palma Carrillo y sometidos a juicio por tres expertos. Los datos fueron procesados utilizando el software Excel y SPSS, utilizando como prueba estadística el coeficiente de correlación de Spearman.Conclusión. Existe una relación significativa entre el clima organizacional y la satisfacción laboral, dado que el valor encontrado de p=0.000 es menor que el nivel de  significancia considerado, α=0.05, y que el grado de correlación es moderada por ser el valor de Rho encontrado de 0.521. Palabras claves: Clima organizacional, satisfacción laboral y educación. ABSTRACTThe overall objective of the study was to determine the relationship between organizational  climate and job satisfaction of teachers Condevilla Network No 11 San Martín de Porres.2013.The population consisted of 300 teachers, being the chosen sample of 171 teachers.The population consisted of 300 teachers, being the chosen sample of 171 teachers. Data were collected through surveys nationally validated by the psychologist Sonia Carrillo Palma trial for three experts. Data Were collected through surveys Nationally validated by the psychologist Sonia Carrillo Palma trial for three experts. The data were processed using Excel and SPSS software, using statistical test the Spearman correlation coefficient. The data Were processed using Excel and SPSS software, using statistical test the Spearman correlation coefficient. Conclusion. There isThe results indicate a significant relationship between organizational climate and job satisfaction, as the value found for p = 0.000 is less than the significance level considered, α = 0.05, and that the degree of correlation is moderate as the Rho value of 0.521 found. a significant relationship Between organizational climate and job satisfaction, as the value found for p = 0.000 is less than the significance level considered, α = 0.05, and That the degree of correlation is moderate as the Rho value of 0.521 found. Key words : organizational climate, job satisfaction and educationKey words: organizational climate, job satisfaction and education
CRECIMIENTO ECONÓMICO E INGRESOS TRIBUTARIOS DEL PERÚ. /ECONOMIC GROWTH AND TAX REVENUES OF PERU.
Authors: Ordoñez Ferro Mg.  Ana Cecilia
Published: November 2017

RESUMEN El propósito de la investigación ha sido determinar la relación entre el crecimiento económico y los ingresos tributarios del Perú en los años 1990 y 2010.En tal sentido, se estableció los indicadores que expresarían empíricamente dichas variables, se recopiló y ordenó la información existente que nos permitió describir la estructura y evolución de cada una de dichas variables y establecer la relación que había entre ellas.La investigación ha permitido establecer de qué manera se han comportado los indicadores del crecimiento y de los impuestos en el Perú, tanto en términos absolutos como relativos y de qué manera están relacionados dichos indicadores. Adicionalmente, podemos apreciar que, la tendencia creciente de la economía peruana, expresada en el aumento de la producción y los impuestos como la presión tributaria sigue siendo aún exigua.PALABRAS CLAVES: Crecimiento económico, ingresos tributarios, estado. ABSTRACTThe purpose of the research was to determine the relationship between economic growth and tax revenues of Peru in the years 1990 y 2010.In this regard, the indicators established empirically express these variables, collect and collate existing information to allow us to describe the structure and evolution of each of these variables to establish the relationship that existed between them.The research has allowed to establish how the indicators have performed growth and taxation in Peru, both in absolute and relative terms, and how these indicators are related. Additionally, we see that, despite the growing trend of the Peruvian economy, expressed in increased production and taxes, the tax burden remains low.KEY WORDS: economic growth , tax revenue, state.
CÓMO MOTIVAR A UTILIZAR EL TRANSPORTE PÚBLICO EN LIMA METROPOLITANA.HOW DO YOU ENCOURAGE TO USE PUBLIC TRANSPORT IN METROPOLITAN LIMA?
Authors: Cossio Carlín : Mg. Alfonso
Published: November 2017

RESUMENEl Objetivo General de la presente investigación fue determinar las causas que han incrementado abruptamente el parque automotor de Lima Metropolitana, con el propósito de incentivar a utilizar con mayor frecuencia el transporte público, como solución al caos vehicular que todos los ciudadanos padecemos diariamente. La investigación buscó alternativas de solución para que el ciudadano que posee un automóvil, prefiera movilizarse en transporte público en rechazo al sufrimiento que vive día a día por la congestión vehicular, tal como sucede en las grandes ciudades modernas.Por lo que en el presente artículo se presentan los siguientes ítems:IntroducciónMaterial y MétodoResultadosDiscusiónConclusionesBibliografíaPalabras claves: Parque automotor, caos vehicular, congestión vehicular.ABSTRACTThe general objective of this study was to determine the causes which have sharply increased the automotive park of Lima, in order to encourage more frequent use public transport, as a solution to traffic chaos all citizens suffer daily.The study searched alternative solutions for the citizen who owns a car mobilize public transport prefer to reject the suffering living day by traffic congestion, as in the modern cities.So in this article, the following items were presented:•Introduction •Material and Method•Results •Discussion •Conclusions • BibliographyKey words: Automotive Park, traffic chaos, traffic congestion.
IMPLEMENTACIÓN DE UN SISTEMA DE CONTROL INTERNO EN LA OPTIMIZACIÓN DE LA GESTIÓN ADMINISTRATIVA EN LA ASOCIACION DE CENTROS DE ESPARCIMIENTO DE LA GUARDIA CIVIL
Authors: Lopez Flores Catalina Del carmen
Published: November 2017

IMPLEMENTACIÓN DE UN SISTEMA DE CONTROL INTERNO EN LA OPTIMIZACIÓN DE LA GESTIÓN ADMINISTRATIVA EN LA ASOCIACION DE CENTROS DE ESPARCIMIENTO DE LA GUARDIA CIVIL
IMPLEMENTACIÓN DE UN PLAN ESTRATÉGICO PARA EL FORTALECIMIENTO DE LA PROMOCIÓN DE LOS RECURSOS TURÍSTICOS EN LA PROVINCIA DE HUARMEY 2016
Authors: Hernandez Martinez Miguel
Published: November 2017

IMPLEMENTACIÓN DE UN PLAN ESTRATÉGICO PARA EL FORTALECIMIENTO DE LA PROMOCIÓN DE LOS RECURSOS TURÍSTICOS EN LA PROVINCIA DE HUARMEY 2016
“Análisis de la calidad del servicio de los Hoteles Blue Star y Marqués en el distrito de san isidro, 2017”
Authors: Pecho Rafael Mélida Herlinda , Gutiérrez Mullisaca Naysha
Published: November 2017

Objetivo: Determinar el servicio de calidad en el hotel Blue Star y Márquez en el distrito de san Isidro, 2016. Materiales y métodos: La presente investigación es de tipo, no experimental, descriptivo simple y descriptivo comparativo. Descriptivo simple porque se va a buscar y recoger información-datos acerca del tema de calidad que los hoteles blue Star y Márquez brindan a sus huéspedes, con el fin de obtener información para poder tomar una decisión con respecto al problema.  Descriptivo comparativo porque se va a recolectar información de varios testimonios sobre un mismo tema, para luego comparar los datos recogidos. La presente investigación es de muestra probabilística, de tipo aleatorio simple, porque se va a estudiar una población que está conformada por 381 huéspedes, que tengan entre 25 y 50 años, de sexo masculino y femenino, para encuestarlos acerca del servicio que se les ha brindado en los hoteles de Blue Star  y Márquez. La técnica que se va a utilizar es la encuesta porque se va a recoger testimonios de los huéspedes acerca de la calidad servicio que les brinda los hoteles Blue Star y Márquez. Resultados: De los 100 huéspedes encuestados, se puede observar que un 79% de las personas piensan que los trabajadores tienen el suficiente conocimiento para poder brindar una información adecuada para el conocimiento de los clientes, pero que les falta un poco más de capacitación, por otra parte un 21% piensan que los trabajadores son muy competentes, que tienen un alto conocimiento de información acerca de los servicios que los hoteles brindan. Conclusión: Se concluye que el 79% de los huéspedes piensan que el personal del hotel cuenta con el conocimiento debido para brindar información que el cliente necesita, si domina los precios y las políticas que el hotel exige, el huésped también califica si el trabajador si es lo suficientemente competente para atenderlo, si es cortes desde el principio, brindándole una sonrisa en todo momento para que el cliente se sienta cómodo y le inspire confianza. Pero un 21% piensan que les falta un poco mas de capacitación con respecto a la atención a los clientes ya que no se siente satisfecho por completo con la atención que se está brindando. Según Servqual el comportamiento de los trabajadores de una empresa ya sea nacional e internacional debe transmitir confianza a sus clientes para que se sientan seguros en sus transacciones con la empresa de servicio. Los empleadores de la empresa de servicio siempre deben ser amables con los clientes y por último los trabajadores deben tener los conocimientos suficientes para responder a las preguntas de los clientes.Palabras claves: calidad.
“Evaluación del liderazgo del equipo directivo y su relación con el desempeño de los docentes de la I.E. 0069 Machu Picchu Red 09- UGEL 05 San Juan de Lurigancho -2015”
Authors: Gamarra Mendoza Sofía
Published: November 2017

El presente trabajo de investigación es el fruto del gran esfuerzo y privaciones familiares, para investigar acerca de la relación del liderazgo del equipo directivo y como este influye en el desempeño docente de su institución, con el firme propósito de mejorar la calidad de la educación en nuestro país.En estos tiempos, el liderazgo propuesto por el del maestro líder se ha convertido en un elemento básico de cualquier intento de modernización educativa y con ello el mejoramiento del desempeño docente, por lo tanto, es impostergable la necesidad de investigar y publicar los resultados obtenidos en esta modesta investigación para ayudar a quienes tienen la responsabilidad de dirigir instituciones educativas a nivel nacional.En tal sentido, se analiza el liderazgo empleado por los directivos para poner en acción a su equipo para la obtención de logros y metas que tiene una relación directa con el desempeño docente que muestren los maestros bajo su dirección y, para lograrlo es indispensable que estas metas sean fijadas de común acuerdo, sólo así es posible despertar el interés y la motivación para trabajar juntos hasta conseguir lo propuesto.Palabras claves: Gestión pedagógica, calidad del servicio educativo.
Fluoride Accumulation in Groundwater from Semi-arid Part of Deccan Volcanic Province, India: A Cause of Urolithiasis Outbreak
Authors: Kale Sanjay , Pawar N. J.
Published: November 2017

Groundwater fluoride and health problem was meticulously studied for dental and skeleton fluorosis except few studies on urolithiasis. Urolithiasis is multi-factorial disease and excess fluoride consumption is one of the causal factors. In view of this, increase of fluoride in groundwater is reported in semiarid Deccan Volcanic Province (DVP), India. To understand the fluoride and urolithiasis association, present study was carried out in Karha river basin of DVP region. Three stages of data generation were adopted for present study such as procuring of medical records of urolithiasis, previous groundwater chemistry data and geochemical investigation of 50 groundwater samples from representative villages. Further, these variables were used for correlation analysis, temporal and spatial distribution to find out their relationships. Result shows medical records of hospitals indicating the gradual increase in urolithiasis is reported during drought situations. In temporal variation, annual fluoride concentration of groundwater and hot days are positively correlated with annual urolith patients as well as spatial study supports the same. In conclusion, present study highlights the relationship of urolith formation with number of hot days, groundwater electrical conductivity and fluoride. However, detailed biomedical study may lead towards understanding of fluoride- urolithiasis relationship.
Revealing hydrological relations of adjacent karst springs by partial correlation analysis
Authors: Kadić Ana , Denić-Jukić Vesna , Jukić Damir
Published: November 2017

The objective of this work is the study of two adjacent karst springs, Jadro and Žrnovnica, in Croatia. This work focuses on the effects of temperature, relative humidity, rainfall and discharges on the hydrological behavior and relations of two adjacent karst springs. Partial correlation analysis reveals the type of the control signal that affects the cross-correlation function between an input and output signal. It has been confirmed that in the case of the adjacent karst springs Jadro and Žrnovnica, the discharge of the Žrnovnica Spring has an impact on the rainfall-discharge relation of the Jadro Spring. The demonstrated approach represents an improvement in investigating the relations of adjacent karst springs and could be used as an integral part of their hydrological and hydrogeological investigations, considering that the necessary data can occur in a relatively simple and inexpensive manner.
Hydraulic characteristics of varying slope gradients, rainfall intensities and litter cover on vegetated slopes
Authors: Sun Jiamei , Fan Dengxing , Yu Xinxiao , Li Hanzhi
Published: November 2017

Litter produced by forests performs crucial functions in rainfall interception and soil conservation, particularly in the condition that larger raindrops formed by canopy accelerate soil erosion. To explore how forest litter exerts runoff hydrological characteristics and sediment yield processes, experiments on forest covered (Vitexnegundo var. heterophylla) slopes were conducted under various combinations of rainfall intensities and slope gradients. The results showed that litter reduced runoff yield rate by 9–31% and reduced sediment yield rate by 65–90%, with mean runoff and sediment reductions of 18% and 76% for all treatments. On forest covered slopes, Reynolds number and runoff power generally increased with the increase in both rainfall intensity and slope gradient. Litter layer reduced Reynolds number and runoff power with 8–29% and 56–80%, respectively. Darcy–Weisbach resistance coefficient decreased by increasing rainfall intensity and slope gradient. Litter layer increased Darcy–Weisbach resistance coefficient by three to nine times. Relationships between sediment yield rate and Reynolds number, runoff power, Darcy–Weisbach resistance coefficient were described by exponential, linear, power functions, respectively. The critical runoff power values for slopes with and without litter were 0.0027 and 0.0010 m/s, respectively. Reynolds number was the best hydrodynamic parameter for dynamic erosion characterizing.
Immobilization of halophilic yeast for effective removal of phenol in hypersaline conditions
Authors: Jiang Yu , Yang Kai , Deng Tao , Ji Bin , Shang Yu , Wang Hongyu
Published: November 2017

A halotolerant yeast strain of Candida sp. was purified for phenol biodegradation and was immobilized in alginate and nano-SiO2. The concentration of nanoscale SiO2 was optimized and phenol degradation performance with different initial phenol concentrations was evaluated. Three common kinetic models were used to correlate the experimental data. The effects of pH and salinity on phenol biodegradation were also investigated. It was found that 1.0% (w/v) was the optimal nano-SiO2 concentration and the immobilized cells had a better phenol removal performance compared to free cells. More than 99% of 600 mg l−1 phenol was removed by the immobilized strains within 48 h. The immobilized cells also showed highest phenol degradation rates when pH and salinity were 6.5 and 0%, respectively. The high removal efficiency of phenol in reusability tests indicated the promising application of the immobilized Candida strain in phenol degradation under hypersaline conditions over a long period.
Test of precoat filtration technology for treatment of swimming pool water
Authors: Christensen Morten Lykkegaard , Klausen Morten Møller , Christensen Peter Vittrup
Published: November 2017

The technical performance of a precoat filter was compared with that of a traditional sand filter. Particle concentration and size distribution were measured before and after the filtration of swimming pool water. Both the sand and precoat filters could reduce the particle concentration in the effluent. However, higher particle removal efficiency was generally observed for the precoat filter, especially for particles smaller than 10 μm in diameter. Adding flocculant improved the removal efficiency of the sand filter, resulting in removal efficiencies comparable to those of the precoat filter. Three powders, i.e., two types of perlite (Harbolite® and Aquatec perlite) and cellulose fibers (Arbocel®), were tested for the precoat filter, but no significant difference in particle removal efficiency was observed among them. The maximum efficiency was reached within 30–40 min of filtration. The energy required for the pumps increased by approximately 35% over a period of 14 days. The energy consumption could be reduced by replacing the powder on the filter cloth. The sand filter was backwashed once a week, while the powder on the precoat filter was replaced every two weeks. Under these conditions, it was possible to reduce the water used for cleaning by 88% if the precoat filter was used instead of the sand filter.
Off-pump myocardial revascularization safety aspects in combined operations on patients with ischemic heart disease complicated by ischemic mitral regurgitation
Authors: Zavologhin A. , Shonbin A. , Bystrov D. , Elizarov M. , Ivanov G.
Published: November 2017

Aim. The issues of safety of off-pump myocardial revascularization in patients with severe ischemic mitral regurgitation remain insufficiently studied. Control of transport and oxygen consumption allows one to assess some of the safety aspects of this technique. The study was designed to evaluate the safety of myocardial revascularization without cardiopulmonary bypass in a combined operation for patients with ischemic mitral regurgitation and a similar operation under cardiopulmonary bypass and cardioplegia by assessment of the main parameters of transport and oxygen consumption.Methods. Forty-two adult patients scheduled for elective coronary artery bypass grafting in combination with mitral annuloplasty were randomized into two groups: off-pump (22 patients) and on-pump (20 patients). In the off-pump group, coronary artery bypass grafting was performed on a beating heart without cardiopulmonary bypass, whereas in the on-pump group it was conventional coronary artery bypass grafting on a cardiopulmonary bypass with cardiac arrest. The coronary artery bypass grafting stage was performed before intervention on the mitral valve.Results. On completion of the coronary artery bypass grafting stage, the cardiac index, the oxygen delivery index and the blood lactate level in the off-pump group were lower than those in the on-pump group by 20%, 17% and 100% (p = 0.01, 0.02, 0.003), respectively, while the consumption index and oxygen extraction were higher by 17% and 94% (p = 0.016 and 0.0001), respectively. In the off-pump group, the oxygen consumption index remained stable at all stages of the operation and the C-reactive protein level tended to decrease between 10–14 days after surgery (p = 0.13).Conclusion. Implementation of off-pump coronary surgery in a combined operation for patients with ischemic mitral regurgitation does not lead to disruption of transport and oxygen consumption, does not exacerbate the systemic inflammatory response and can be considered a safe method for this category of patients.Received 5 April 2017. Revised 21 July 2017. Accepted 24 July 2017.Funding: The study did not have sponsorship.Conflict of interest: The authors declare no conflict of interest.Author contributionsConception and study design: A.S. Zavolozhin, A.N. ShonbinData collection and analysis: A.S. Zavolozhin, D.O. Bystrov, M.V. Elizarov, G.A. Ivanov Drafting the article: A.S. ZavolozhinCritical revision of the article: A.N. Shonbin, D.O. BystrovFinal approval of the version to be published: A.N. ShonbinAcknowledgement: The authors express their gratitude to the staff of cardiac surgeons of City Hospital No. 1 (Arkhangelsk) for collaboration and support in doing this research.
Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study
Authors: Melynikov M. , Zelinskiy V.
Published: November 2017

Aim. The study was designed to assess the specific features of manifestation and progression for critical low limb ischemia in patients with abdominal aortic calcification. Methods. The total of 151 patients with low limb critical ischemia due to peripheral arterial disease were enrolled to the study cohort: 79 patients (study group) with abdominal aortic calcification and 72 patients (control group) without any signs of abdominal aortic wall calcification. Abdominal aortic calcification was detected by CT-imaging. The patients with diabetes mellitus and with chronic renal insufficiency were excluded from the study cohort. Results. Critical lower limb ischemia in subjects with abdominal aortic calcification manifested itself in the following features: predominant localization of lesions in the aorto-iliac position (68.4% vs. 33.3% in patients without abdominal aortic calcification; р<0.05), rapid progression of lower limb ischemia (its prevalence in the study group was 77.7% vs. 37.3% in the control group; р<0.01), expressed hypercoagulation combined with a decrease in the level of natural anticoagulants concentration (mean activity of antithrombin III in individuals with abdominal aortic calcification was 56.5±10.4% vs. 98.7±16.4% in patients without abdominal aortic calcification; р<0.001). Conclusion. The study findings have shown that critical lower limb ischemia in subjects with abdominal aortic calcification has specific futures of manifestation and clinical course that need to be considered when choosing the best treatment strategy.Received 24 April 2017. Revised 7 June 2017. Accepted 19 June 2017.Funding: The study did not have sponsorship.Conflict of interest: The authors declare no conflict of interest.
Prospective rAndomized, single-blind, mulTicenter study of sirolimus-eluting coRonary stent “Calypso” vs everolimus-eluting cOronary stenT “XiencePrime”: results of the PATRIOT trial
Authors: Prokhorikhin A. , Baystrukov V. , Grazhdankin I. , Ponomarev D. , Verin V. , Osiev A. , Ganyukov V. , Protopopov A. , Dyomin V. , Abugov S. , Boykov A. , Malaev D. , Karaskov A. , Pokushalov E. , Kretov E.
Published: November 2017

Aim. This trial was aimed at comparing the efficacy and safety of sirolimus-eluting coronary stent “Calypso” (Angioline) and everolimus-eluting coronary stent “XiencePrime” (Abbott Vascular) when used for treatment of ischemic heart disease patients.Methods. The trial included patients suitable for coronary revascularization with coronary stenting. They underwent a standard revascularization procedure and were randomized in 2:1 ratio to receive “Calypso” coronary stent (Angioline) (n = 407) or “XiencePrime” coronary stent (AbbottVascular) (n = 203). The follow-up period was 12 months. In order to detect restenosis (secondary endpoint), angiographic follow-up was performed in 20% of cases at 12 months. The trial protocol had no limitations regarding the length of lesions, number of target lesions and number of implanted stents. The main exclusion criterion was STEMI. The composite primary endpoint included one-year target lesion-related complications determined as cardiogenic death, target vessel myocardial infarction, clinically indicated target lesion revascularization. The primary endpoint data were evaluated by an independent committee.Results. In the trial, 55% of patients had acute coronary syndrome with ST elevation and type C lesions were detected in 46% of cases. In “Calypso” and “XiencePrime” groups, TLF occurred in 5.4% and 6.4% respectively (absolute risk difference in TLF accounted for 1%, 95% CI [---;2.1%]; p non-inferiority = 0.017). Thus, the hypothesis of non-inferiority of “Calypso” as compared to “XiencePrime” was confirmed. The incidence of stent thrombosis (definite and probable) was relatively low and had no significant differences between “Calypso” and “XiencePrime” groups (0.73% and 0%; p>0.05). Definite stent thrombosis was noted in two cases in the “Calypso” group (0.49%), in one case the cause of thrombosis turned out to be incomplete stent expansion after implantation.Conclusion. “Calypso” sirolimus eluting stent was not inferior to “XiencePrime” everolimus-eluting stent in treating patients with coronary heart disease.Received 7 November 2017. Revised 13 November 2017. Accepted 20 November 2017.Funding: The study was funded by “Angioline Interventional Devices” (Novosibirsk, Russian Federation). The supporting source had no involvement in study design; collection, analysis and interpretation of data; writing of the report; and in the decision to submit the article for publication.Conflict of interest: The authors declare no conflict of interest.
High-Throughput Screening Strategies for the Development of Anti-Virulence Inhibitors Against Staphylococcus aureus
Authors: Cai Xiaodan , Zheng Weihao , Li Zigang
Published: November 2017

Background:

The increasing threats of antibiotic resistance urge the need for developing new approaches to combat bacterial infections including those caused by Staphylococcus aureus (S. aureus). Unlike conventional antibiotics that aim to kill bacteria or inhibit their growth, targeting bacterial virulence may be a promising alternative approach, which imposes less selective pressure for antibiotic resistance in future generations.

Objective:

Our goal is to provide a systematic review about developing high-throughput screening (HTS) strategies for the identification of inhibitors targeting virulence of S. aureus. We also describe an overview of virulence regulatory pathways for potential antivirulence targets.

Methods:

We focus on five potential targets or target families, including agr quorum sensing system, SarA/MgrA protein family, sortase A, Clp protease and eukaryotic-like Ser/Thr phosphatase (Stp1). For each target, we introduce its role in virulence regulation, summarize the HTS approaches that are used to identify novel anti-virulence inhibitors, and discuss the advantages and disadvantages of these strategies.

Conclusion:

The discovery of anti-virulence inhibitors via HTS underlines the promising potential of anti-virulence therapy for S. aureus. The development of HTS strategies can facilitate the identification of novel anti-virulence inhibitors for combating S. aureus infection, and may also advance our understanding on virulence regulation in S. aureus.
Advances on Automatic Speech Analysis for Early Detection of Alzheimer Disease: A Non-linear Multi-task Approach
Authors: Lopez-de-Ipina Karmele , Martinez-de-Lizarduy Unai , Calvo Pilar M. , Mekyska Jiri , Beitia Blanca , Barroso Nora , Estanga Ainara , Tainta Milkel , Ecay-Torres Mirian
Published: November 2017

Objective: Nowadays proper detection of cognitive impairment has become a challenge for
the scientific community. Alzheimer's Disease (AD), the most common cause of dementia, has a high
prevalence that is increasing at a fast pace towards epidemic level. In the not-so-distant future this fact
could have a dramatic social and economic impact. In this scenario, an early and accurate diagnosis of
AD could help to decrease its effects on patients, relatives and society. Over the last decades there have
been useful advances not only in classic assessment techniques, but also in novel non-invasive screening
methodologies.

Methods:

Among these methods, automatic analysis of speech -one of the first damaged skills in AD
patients- is a natural and useful low cost tool for diagnosis.

Results:

In this paper a non-linear multi-task approach based on automatic speech analysis is presented.
Three tasks with different language complexity levels are analyzed, and promising results that encourage
a deeper assessment are obtained. Automatic classification was carried out by using classic Multilayer
Perceptron (MLP) and Deep Learning by means of Convolutional Neural Networks (CNN) (biologically-
inspired variants of MLPs) over the tasks with classic linear features, perceptual features, Castiglioni
fractal dimension and Multiscale Permutation Entropy.

Conclusion:

Finally, the most relevant features are selected by means of the non-parametric Mann-
Whitney U-test.
Easy Screening for Mild Alzheimer's Disease and Mild Cognitive Impairment from Elderly Speech
Authors: Kato Shohei , Homma Akira , Sakuma Takuto
Published: November 2017

Objective: This study presents a novel approach for early detection of cognitive impairment
in the elderly. The approach incorporates the use of speech sound analysis, multivariate statistics, and
data-mining techniques. We have developed a speech prosody-based cognitive impairment rating
(SPCIR) that can distinguish between cognitively normal controls and elderly people with mild Alzheimer's
disease (mAD) or mild cognitive impairment (MCI) using prosodic signals extracted from elderly
speech while administering a questionnaire. Two hundred and seventy-three Japanese subjects (73
males and 200 females between the ages of 65 and 96) participated in this study. The authors collected
speech sounds from segments of dialogue during a revised Hasegawa's dementia scale (HDS-R) examination
and talking about topics related to hometown, childhood, and school. The segments correspond to
speech sounds from answers to questions regarding birthdate (T1), the name of the subject's elementary
school (T2), time orientation (Q2), and repetition of three-digit numbers backward (Q6). As many prosodic
features as possible were extracted from each of the speech sounds, including fundamental frequency,
formant, and intensity features and mel-frequency cepstral coefficients. They were refined using
principal component analysis and/or feature selection. The authors calculated an SPCIR using multiple
linear regression analysis.

Conclusion:

In addition, this study proposes a binary discrimination model of SPCIR using multivariate
logistic regression and model selection with receiver operating characteristic curve analysis and reports
on the sensitivity and specificity of SPCIR for diagnosis (control vs. MCI/mAD). The study also reports
discriminative performances well, thereby suggesting that the proposed approach might be an effective
tool for screening the elderly for mAD and MCI.
Brain Structural Magnetic Resonance Imaging for Joint Independent Component Analysis in Schizophrenic Patients
Authors: Chu Wen-Lin , Huang Min-Wei , Jian Bo-Lin , Cheng Kuo-Sheng
Published: November 2017

Background:

In past magnetic resonance imaging studies, normal participants and
schizophrenia patients have usually been compared using imaging processing modes with only one
parameter. A more extensive evaluation of significant differences between gray and white matter in
Schizophrenic patents was necessary.

Methods:

Voxel based morphometry was used to separate brain images into gray matter and white
matter. Then, the images were mapped to Montreal Neurological Institute space, and DARTEL
analytic template was applied for image calibration with statistical parametric mapping. Finally,
joint independent component analysis was employed to analyze the gray and white matter of brain
images from Schizophrenic patients and normal controls. In this study, joint independent component
analysis was used to discriminate clinical differences in magnetic resonance imaging signals
between Schizophrenic patients and normal controls.

Results:

Region of interest analyses has repeatedly shown gray matter reduction in the superior
temporal gyrus of Schizophrenic patients.

Conclusion:

These results strongly support previous studies regarding brain volume in schizophrenic
patients. The connection networks in frontal and temporal lobes evidently did not differ between
normal participants and schizophrenia patients.
The Social Determinants of Healthcare Access for Rural Elderly Women - A Systematic Review of Quantitative Studies
Authors: Hamiduzzaman Mohammad , De Bellis Anita , Abigail Wendy , Kalaitzidis Evdokia
Published: November 2017

Objective:

This review aimed to explore and analyze the social determinants that impact rural women’s aged 60 years and older healthcare access in low or middle income and high income countries.

Methods:

Major healthcare databases including MEDLINE and MEDLINE In-Process, PsycINFO, PubMed, ProQuest, Web of Science, CINAHL and ERIC were searched from April 2016 to August 2016 and a manual search was also conducted. A rigorous selection process focusing on the inclusion of rural elderly women in study population and the social determinants of their healthcare access resulted in 38 quantitative articles for inclusion. Data were extracted and summarized from these studies, and grouped into seven categories under upstream and downstream social determinants.

Results:

Prevailing healthcare systems in combination with personal beliefs and ideas about ageing and healthcare were identified as significant determinants. Socioeconomic and cultural determinants also had a statistically significant negative impact on the access to healthcare services, especially in developing countries.

Conclusion:

Potentially, improvements to healthcare access can be achieved through consideration of rural elderly women’s overall status including healthcare needs, socioeconomic determinants and cultural issues rather than simply establishing healthcare centers.
Pengembangan media pembelajaran biologi berbantuan komputer untuk meningkatkan hasil belajar peserta didik
Authors: Mukti Intan Nur Cahya , Nurcahyo Heru
Published: November 2017

Penelitian ini bertujuan untuk (1) menghasilkan media pembelajaran berbantuan komputer yang berkualitas sehingga layak digunakan untuk pembelajaran biologi kelas XI SMA materi sistem pernapasan pada manusia; (2) mengetahui tanggapan peserta didik setelah menggunakan media pembelajaran yang dikembangkan; (3) mengetahui hasil belajar peserta didik setelah menggunakan media pembelajaran berbantuan komputer hasil pengembangan. Penelitian ini merupakan research and development (R&D) yang menggunakan model 4-D. Subjek uji coba adalah peserta didik kelas XI SMA N 1 Tanjungsari Gunungkidul, Instrumen pengumpulan data adalah lembar angket, lembar observasi, dan soal pretest dan posttest. Hasil penelitian adalah sebagai berikut: (1) Media pembelajaran berbantuan komputer hasil pengembangan ditinjau dari aspek materi dan media berkategori sangat baik. (2) Tanggapan peserta didik yaitu setuju untuk menggunakan media pembelajaran berbantuan komputer hasil pengembangan. (3) Terjadi peningkatan hasil belajar kategori tinggi dengan rerata skor gain sebesar 0,702, dan terjadi peningkatan ketuntasan hasil belajar sebesar 83,333%. Hasil tersebut menunjukkan bahwa media pembelajaran biologi berbantuan komputer materi sistem pernapasan pada manusia hasil pengembangan layak digunakan untuk meningkatkan hasil belajar peserta didik kelas XI. Developing Computer-Based Biology Learning Media to Improve the Students’ Learning Outcomes AbstractThis study aims to (1) produce computer-based learning media with quality to be suitable for biology learning for Grade XI of senior high schools for the topic of the human respiration system, (2) find out students’ responses to the learning through the developed computer-based learning media, (3) find out students’ learning outcomes after the use of the developed computer-based learning media. This was a research and development (R&D) study using the 4-D model. The product tryout was carried out by involving Grade XI students of SMA N 1 Tanjungsari, Gunungkidul. The data were collected through a questionnaire, an observation sheet, a pretest, and a posttest. The result of the study is as follows. (1) The developed computer-based learning media in terms of the material and media aspects are in the very good category. (2) The students’ responses show their agreement to the use of the developed computer-based biology learning media. (3) There is an improvement of learning outcomes in the high category with an average gain score of 0.702 and an improvement of the learning outcome mastery of 83.333%. This shows that the developed computer-based biology learning media for the topic of the human respiration system is appropriate to improve the learning outcomes of Grade XI.
भारत की आदिवासी महिलाएँ एवं वर्तमान चुनौतियाँ
Authors: सोनोने . गुणवंत
Published: November 2017

:
प्राचीन काल से वर्तमान समय तक की ऐतिहासिक पृष्ठभूमि देशज समुदाय (आदिवासी, जनजाति, आदिम) की आव्हानात्मक एवं आंदोलनात्मक रही है | देशज समाज की भाषा, जीवन पद्धति, मानव समाज एवं विश्व के प्रति दृष्टिकोण, संस्कृति आदि के संदर्भ में विशेषताएं गैर देशज समुदाय से अलग है | जल, जंगल, जमीन, प्राकृतिक संसाधनों पर देशज समाज का विशेषाधिकार रहा है | जल, जंगल, जमीन, प्राकृतिक संसाधन आदि पर्यावरणीय घटक देशज समाज की संस्कृति बनी है | प्राकृतिक संसाधनों का संरक्षण प्रमुखत: से देशज समुदाय ने किया है | प्रकृति के साथ इनका मजबूत रिश्ता है | इन विशेषताओं के कारण देशज समाज की एक अलग पहचान है |
सामाजिक, सांस्कृतिक, आर्थिक, राजकीय दृष्टिकोण से देशज समाज के साथ गैर-देशज समुदाय ने अलगाव बनाएं रखा | इस कारणवश देशज समुदाय की गैर-देशज समुदाय की तुलना में सभी क्षेत्रों में प्रगति संभव नहीं हो पायी है | बदलते वर्तमान परिप्रेक्ष में देशज समुदाय गैर-देशज समुदाय के संपर्क में आने से प्रगति के नये आयाम खुलने लगे है | विभिन्न धार्मिक संगठनों ने वैचारिक एवं धार्मिक प्रसार के लिए देशज समुदाय से संपर्क स्थापित किये | गैर-देशज समुदाय की संस्कृति और देशज समाज की संस्कृति परस्पर प्रभावित हुई | गैर- देशज समाजों की अंत:र्क्रिया और हस्तक्षेप के परिणामस्वरूप देशज समाज के सामाजिक-सांस्कृतिक दृष्टी से काफी बदलाव आया है | देशज समाज की सामाजिक, सांस्कृतिक, आर्थिक क्षेत्र में पुरुष और महिलाओं का उत्तरदाइत्व और निर्णय में स्थान एवं अधिकार समान है | उत्पादक क्षेत्र में महिलाओं की भागीदारी समान है | देशज समाज महिलाओं के संदर्भ में हिंसा मुक्त समाज माना जाता है | गैर-देशज समाज एवं विश्व के परिवर्तनीय घटकों के संपर्क में आने से देशज समाज विशेषत: महिला जीवन प्रभावित हुवा है |
प्राकृतिक संसाधन संरक्षण, शिक्षा, उत्पादक कार्य, सामाजिक- सांस्कृतिक क्षेत्र, मूलाधिकार, शासकीय निति आदि के सन्दर्भ में चुनौतियां है | चेतना राष्ट्रीय विकसित कर हम देशज समाज की महिलाओं को वर्तमान चुनौतियों का सामना करने के लिए सक्षम बना सकते है |
Healthy Body Image Intervention Delivered to Young Women via Facebook Groups: Formative Study of Engagement and Acceptability (Preprint)
Authors: Stapleton Jerod L , Manne Sharon L , Day Ashley K , Levonyan-Radloff Kristine , Pagoto Sherry L
Published: November 2017

BACKGROUND

There is increasing interest in using social media sites such as Facebook to deliver health interventions so as to expose people to content while they are engaging in their usual social media habit. This formative intervention development study is novel in describing a preliminary test of using the secret group feature of Facebook to deliver a behavioral intervention targeting users of indoor tanning beds to reduce their risk of skin cancer. Intervention content was designed to challenge body image-related constructs associated with indoor tanning through the use of dissonance-inducing content.

OBJECTIVE

To evaluate engagement with and acceptability of using a secret Facebook group to deliver a healthy body image intervention to young women engaged in indoor tanning.

METHODS

Seventeen young women completed a baseline survey and joined a secret Facebook group with intervention content delivered via daily posts for 4 weeks. Engagement data was extracted and acceptability was measured via a follow-up survey.

RESULTS

The study had a high retention rate (94%, [16/17]). On average, posts were viewed by 91% of participants, liked by 35%, and commented on by 26%. The average comment rate was highest (65%) for posts that elicited comments by directly posing questions or discussion topics to the group. Average intervention acceptability ratings were highly positive and participants reported feeling connected to the group and its topic. Average rates of past 1-month indoor tanning reported following the intervention were lower than the baseline rate (P=.08, Cohen d=0.47).

CONCLUSIONS

This study is novel in demonstrating participant engagement with and acceptability of using Facebook secret groups to deliver a dissonance-inducing intervention approach that utilizes group-based discussions related to body image. The study is also unique within the field of skin cancer prevention by demonstrating the potential value of delivering an indoor tanning intervention within an interactive social media format. The findings suggest that Facebook metrics of intervention post engagement (ie, likes and comments) may vary based on post types and that designing specifically labeled discussion posts may be helpful for soliciting engagement as well as challenging beliefs.