bluuebunny/crossref_metadata_2025 huggingface dataset:
Patterns of Infections and Antimicrobial Drugs’ Prescribing among Pregnant Women in Saudi Arabia
Authors: Baraka Mohamed A , AlLehaibi Lina Hussain , AlSuwaidan Hind Nasser , Alsulaiman Duaa , Islam Mohamed Ashraful , Alotaibi Badriyah S. , Alboghdadly Amany , Homoud Ali H. , Al-Ghamdi Fuad H. , Ghamdi Mastour S Al
Published: January 2020

Background Antimicrobial agents are considered among the most commonly prescribed drugs in pregnancy given the increased susceptibility of infections during pregnancy. Antimicrobials can contribute to different maternal complications. Therefore, it is important to study their prescribing and utilization pattern. Such type of data regarding this issue is scarce in Saudi Arabia and this encouraged us to conduct this research. The aim of this study is to generate data about the most commonly prescribed antimicrobial agents during pregnancy, as well as their indicators and safety. Methods This is a retrospective study focusing on pregnant women with a known antimicrobial consumption at Johns Hopkins Aramco Healthcare (JHAH). The sample size was 344 pregnant women with 688 antimicrobial prescriptions. Data was collected about prevalence of infections and antimicrobial prescriptions in addition to drug safety during pregnancy using FDA risk categorization system. Results The results showed that Urinary Tract Infections (UTIs) were the most reported (59%) infectious diseases. Around 48% of pregnant women received antimicrobial medications at some point during their pregnancy. The top two antimicrobial agents based on prescription frequency were B-lactams (44.6%) and azole anti-fungals (30%). The prescribed drugs in the study were found to be from B, C and D classes according to the FDA risk classification system. Conclusion Overall antimicrobial prescribing practices were appropriate. The study revealed a high prevalence of antimicrobials prescribing during pregnancy that might pose risks to mothers and their fetuses. Future multi center studies are warranted to evaluate the rational prescribing of antimicrobial medications during pregnancy.
Community-acquired Klebsiella pneumoniae central nervous infection with acute suppurative otitis and bacteremia: a case report in mainland China
Authors: Sun Ruixue , Zhang Hui , Xu Yingchun , Zhu Huadong , Yu Xuezhong , Xu Jun
Published: January 2020

Community-acquiredKlebsiella pneumoniae (K. pneumoniae) central nervous system (CNS) infection combined with bacteremia was rarely identified world. We received a 55-year-old womanwho was under hormone therapy because of Sjogren's syndrome.The onset of this case was acute suppurative otitis,then she developed headache and unconscious, the cerebrospinal fluid (CSF) and imaging examinations were compatible with K. pneumoniae meningitis and suspicious brain abscesses, and K. pneumoniae bacteremia was also combined. Even with adequate antibiotic and supportive therapy, the patient’ relatives refused further assessment of intracranial lesions and took the patient back home, finally the patient died of no spontaneous breathing.Hormone therapy might be the risk factor of community-acquiredK. pneumoniaeinfection. Appropriate antibiotic application and infection focus drainage should be tried for treating this condition. The reason of patient’s death might be the CNS infection combined with K. pneumoniaebacteremia and the absence of intracranial lesion elimination. This case is reported in order to help us know this rare disease and promote a further progress on its pathogenesis and treatment.
Identification of hub genes and a prognostic model associated with ovarian cancer
Authors: Liu Jinhui , jiang pinping , Meng Huangyang , Li Siyue , Nie Sipei , Rui Sun , Jing Yang , Cheng Wenjun
Published: January 2020

Background Ovarian cancer (OC) is one of the most lethal gynecological cancers worldwide. The pathogenesis of the disease and outcomes prediction of ovarian cancer patients remain largely unclear. This study aimed to explore the key genes and biological pathways in ovarian carcinoma development, as well as construct a prognostic model to predict patients’ overall survival. Results We identified 164 up-regulated and 80 down-regulated differentially-expressed genes (DEGs) associated with ovarian cancer. GO term enrichment showed DEGs mainly correlated with spindle microtubes. For KEGG pathways, cell cycle was mostly enriched for the DEGs. The PPI network yielded 238 nodes and 1284 edges. Top three modules and 10 hub genes were further filtered and analyzed. Three candidiate drugs targeting for therapy were also selected. Thirteen OS-related genes were selected and an eight-mRNA model was present to stratify patients into high- and low-risk groups with significantly different survival. Conclusions The identified DEGs and biological pathways may provide new perspective on the pathogenesis and treatments of OC. The identified 8-mRNA signature has significant clinical implication for outcome prediction and tailored therapy guidance for OC patients.
The gut microbiome is more stable in males than in females during the development of colorectal cancer
Authors: Liao Haijun , Li Chaonan , Ai Yingwei , Kou Yongping
Published: January 2020

Background Gut microbial shifts have great potential to predict the risk of colorectal cancer, but how gut microbes respond to the development of colorectal cancer in males and females at the community scale is unknown. To address this question, we reanalyzed the dataset from a published project and grouped these data depending on sex into three groups, healthy, colorectal adenoma and carcinoma individuals, and community assembly and network patterns of gut microbes were evaluated by null model and co-occurrence network-based methods. Results The study showed that distinct changes in microbial α -diversities and community composition were observed between the male and female gut. Specifically, the microbial α -diversities did not significantly change in the male gut ( P > 0.05) but were lowered in the female gut ( P < 0.05), suggesting that permanent species loss might occur in the female gut during the development of colorectal cancer. These distinct changes in microbial α -diversities and community composition between the male and female gut might result from host immunity mechanisms and different microbial community assemblies in males and females. Indeed, we found that the microbial community tended to be primarily stochastic in males, whereas it became increasingly deterministic in females with the development of colorectal cancer. Moreover, microbial co-occurrence associations tended to be more complicated when communities were primarily driven by stochastic processes in males; rare species were enriched in the co-occurrence network of the male gut, whereas key species loss was observed in the co-occurrence network of the female gut. Conclusions Our findings indicate that microbial communities in the male gut are more stable than those in the female gut and that microbial community assembly in the gut is sex-dependent with the development of colorectal cancer. Our study suggests that sexual dimorphism needs to be taken into account to better predict the risk of colorectal cancer based on microbial shifts.
Functional traits of particle-associated microbial assemblages in the low-latitude Pacific Ocean
Authors: Takami Hideto , Tada Yuya , Okubo Takashi , Arai Wataru , Ogura Yoshitoshi , Hayashi Tetsuya , Suzuki Shotaro , Hamasaki Koji
Published: January 2020

Background Organic particles are hotspots for microbial activity and serve as sites of organic matter mineralisation in the water column of marine systems. In nutrient-limited surface water, degradation of organic matter and nutrient regeneration by marine microbes is crucial. Although free-living (FL) bacteria vastly outnumber those on particles, particle-associated (PA) bacteria can reach locally higher concentrations. Accordingly, to achieve a better understanding of marine microbial ecosystems, it is important to elucidate the differences in not only microbial community structures, but also functional traits, between PA and FL environmental sample fractions. In a previous study, we demonstrated that the Genomaple (formerly MAPLE) system could successfully differentiate the functional potentials and diversity of contributors to each function in four metagenomic datasets generated by the Global Ocean Sampling expedition. Hence, we also used this system to highlight functional traits in PA microbial assemblages. Results The PA and FL fractions could be distinguished from one another by their taxonomic compositions, inferred from ribosomal proteins and relative abundance of module functions. Module functions that were more abundant among PA assemblages than FL assemblages were shared between both subtropical gyres, and their taxonomic compositions were similar. Bacterial transport systems associated with adhesive molecules used for forming microbial assemblages through particulate organic matter were more abundant in the PA fractions. Bacterial regulatory system elements for C 4 -dicarboxylate transport and B-vitamin biosynthesis were also abundant among PA assemblages, suggesting mutual relationships between bacteria and algae involved in exchange of nutrient sources. On the other hand, module functions related to amino acid biosynthesis and bacterial transport systems for inorganic nitrogen, phosphorus, and urea were significantly more abundant in the PA assemblages of more oligotrophic North and South Pacific subtropical gyres than eastern equatorial Pacific regions. Conclusions Comprehensive functional metagenomic analyses based on functional abundance revealed some notable functional traits in PA assemblages related to cell adhesion and nutrient acquisition, enabling the microbes to survive in subtropical regions that are more oligotrophic than the equatorial regions.
EXAMINING INSTITUTIONAL ENGLISH LANGUAGE PROGRAM: ENGLISH TEACHER’S PERSPECTIVES AND PRACTICES
Authors: Porras Anthony
Published: January 2020

The issue of what the role of grammar is and how it should be taught is still considered a dilemma among English teachers. Though various schools of thought and methodologies were discovered, the convincing postulations and effective practices in language learning are still in constant exploration. As an attempt to alleviate this dilemma, this research aims to identify teacher beliefs and practices when it comes to grammar. Utilizing a single case study method, perspectives and methodologies were studied from an English teacher in the Philippines. Findings revealed that grammar was still an important aspect in the language learning and teaching. However, fluency was greatly emphasized over accuracy. In practice, Communicative Language Teaching was the most commonly observed method utilized in teaching grammar. It is suggested that there should be a balance between form and function aspects of teaching grammar.
Impact of relative and absolute financial risks on share prices: a Zimbabwe Stock Exchange perspective
Authors: Sixpence Atanas , P. Adeyeye Olufemi , Rajaram Rajendra
Published: January 2020

The impact of financial risks on share prices concerns investors, company executives and accounting standards developers. Investors need this information in delineating their equity valuation models while company executives need the information to make appropriate capital structure decisions. Accounting standards developers use this information in their policy to make accounting standards contemporary. The authors examine the link between relative and absolute financial risks and share prices using a dynamic panel of non-financial listed companies on the Zimbabwe Stock Exchange after dollarization. Equity investors incurred losses before dollarization, which prompted this investigation into the sphere of financial risks in order to explain share price movements so that investors can use it to minimize losses in the future. Absolute financial risk is measured by the total debt, while debt/equity ratio measures relative financial risk. Market capitalization as a proxy for equity and debt is measured by total liabilities. An average debt/equity ratio greater or equal to one qualifies a firm into the high-risk category while ratios below one imply low-risk firms. Results from two-step System Generalised Method of Moments (GMM) show negative and significant connection between relative risk and share prices across risk categories. The impact of absolute risk on share prices differs by risk category. Firm managers are advised to keep total liabilities below market capitalization in order to enjoy the benefits of low-risk categorization. Debt ratio is a reasonable indicator of value and investors can use it in equity valuation. Mandatory reporting of debt ratios should be considered by accounting standards developers.
Management of financial statements auditing in the Visegrad Group countries
Authors: Hinke Jana , Gezo Michal , Smutka Luboš , Strielkowski Wadim
Published: January 2020

This paper aims at comparing the management perspectives with the audit conditions in the Visegrad Group (V4) countries (the Czech Republic, the Slovak Republic, Poland, and Hungary) in the following areas: legislation governing the auditing, statutory duty of auditing, mandatory rotation of auditors in public interest entities, requirements on auditors and professional activities, and audit supervision organizations. The paper also tests the hypothesis whether there is a relationship between the size of the accounting entity and the auditor’s opinion.The methodology is based on the statistical analysis of the data using the Chi-square test of independence applied to a sample of 800 randomly selected accounting entities from all V4 countries (200 per each country in question).The results demonstrated significant differences in the management approaches to financial reporting, especially in the area of the statutory duty of auditing. In addition, quantitative research was conducted to determine whether there is a relationship between the size of the accounting entity and the auditor’s opinion. At the 5% significance level, no such dependence has been found for any of the V4 countries, but at the 10% significance level, the dependence has already been proved in case of the Republic of Poland and Hungary. The practical value of the obtained results is the knowledge of how to manage accounting standards for business entities in the V4 countries, as well as to determine the statutory duty to audit financial statements. These results might be of a special practical importance for business managers, tax authorities, and auditors operating in the EU countries.
Regional features of migrants’ treatment (the case of the Tomsk and Vladimir Regions)
Authors: Filkina Alexandra V. , Bulatova Tatiana A.
Published: January 2020

This article presents a comparative analysis of attitudes toward ethnic migrants in two Russian regions: the Tomsk and Vladimir Regions. Its relevance is associated with a high migration influx of foreign citizens into various Russian regions. According to the UN data (2015), our country is the third in the world in terms of the migrants’ influx. Moreover, there is no reliable and comparable sociological information both about the attitude of the local population to them and about the factors that determine it. Against the backdrop of a growing trend of interethnic tension in relations with migrants, the results of such studies acquire important social and political significance. This article relies on the results of representative questionnaires of the population of the Tomsk (in 2014, 563 respondents) and Vladimir Regions (2015, 500) using the general methodology. In the process of research, groups with different levels of tolerance towards migrants were identified in the “host community”. Subsequently, different groups of tolerance of the population were compared in these two regions. The findings show that the attitude towards migrants in the regions can vary even under similar economic conditions and within the framework of a uniform political situation. Significant differences were found in the size of groups that showed varying degrees of tolerance towards migrants. While in the Tomsk Region, the half of the sample can be attributed to the group of the tolerant people, in the Vladimir Region, their percentage is equal to the xenophobes’. The structure of attitudes towards migrants presents particular interest: for the Tomsk Region, the difference between educational and labor migrants is more significant. The obtained results actualize the issue of factors differentiating attitudes towards migrants in different regions of one country. Based on the results obtained, the authors propose a hypothesis that the specificity of the local urban social and cultural context can occupy an important place among these factors. Therefore, in Tomsk (an educational center), there is an obviously higher level of tolerance towards migrants. The authors speak for additional studies using qualitative methods to test their hypothesis.
Practice and ideology of regional studies of religious security
Authors: Suslov Ivan V.
Published: January 2020

The contemporary Russian map of threats to religious security is multifaceted. The first place in the hierarchy of threats is the activity of radical Islamists promoting extremist goals, while the second place belongs to the activity of non-traditional religions. This article is devoted to the analysis of methodological tools and results of regional and All-Russian sociological surveys aimed at determining the quality of interfaith relations and the place of religious risks in the national security system. Research into the religious sphere requires a certain sensitivity, which only complicates the process of compiling empirical tools. This article analyzes the experience of sociological surveys in the Volga Region (Bashkortostan, Penze, Ulyanovsk, Mordovia, Astrakhan) and the North Caucasus, using the data from All-Russian surveys. The purpose of this article is to identify the most effective methodological strategies for measuring sectarian tension and determining the risk of religious violence. The analysis of methodological tools shows that the high anxiety of mass consciousness can be recorded using questions on a number of issues. They include the admissibility or inadmissibility of violence in interreligious relations; the need to grant special rights to a denomination (to formalize its dominant position); the benefits or harms of the transition from one religion to another; the attitude towards the demonstration of religious symbols in the public sphere (e. g. hijab). The analysis of empirical research strategies allowed recording the tendency to present non-traditional faiths for Russia as a serious threat to the religious security, as well as to unite under a single cap such diverse phenomena as Wahhabism, the movement of Jehovah’s Witnesses, Protestantism, and Krishnaism. On the contrary, Russian political scientists consider traditional religions the main allies of the state in the field of maintaining religious security. The author concludes that the choice of methods can influence individual and collective perceptions of religious security.
Siberian projects as regional multipliers for acceleration of social and economic development
Authors: Mostovaya Elena B.
Published: January 2020

The contemporary deep degradation of the Eastern sector of the Russian Arctic in the post-Soviet period requires solutions, as well as the expansion of the impact of the needs of Siberia and its Arctic territories on the Russian and world economic growth. This article aims to explain how the development of the Arctic can become a source of acceleration of social and economic development of Russia — a driver of development and its multiplier. This emphasizes the importance of following the principle of connectivity in the development of the Eastern sector of the Russian Arctic, when analyzing the sources of complexity the design of its development, performed by the employees of the Institute of Economics and Industrial Engineering, Siberian Branch of the Russian Academy of Sciences (IEIE SB RAS). The article studies the projects of integrated development of the Eastern sector of the Arctic zone of Russia, developed in 2015-2018 by the IEIE SB RAS as potential drivers and multipliers that can accelerate the social and economic development of the entire country. The author emphasizes the non-constructive focus of some researchers on the development of a narrowly understood regional perspective of the problems of developing the potential of the Russian Arctic and justifies the need for a systematic approach to its development in the context of global economic ideas. The article reveals the mental sources of the commitment of the research staff of the IEIE SB RAS to system research, to the implementation of the theory of optimal use of limited natural and economic resources in research projects. The possibility of a significant acceleration of economic growth in Siberia and Russia as a whole during the implementation of Arctic projects, provided that the priority participation of industrially developed and densely populated regions of southern Siberia. The article shows that for the formation and implementation of an effective social and economic strategy of secondary (post-industrial) transformation of the Russian society, it is not enough to specify the current and long-term objectives of the economic movement. The authors concludes that it is of fundamental importance to identify potential drivers and multipliers in their composition that can accelerate the social and economic development of the country.
Turismo colaborativo em hostels: um estudo multicasos
Authors: Telles Gabriela Cornelsen de Queiroz , Cardoso Jaqueline de Fátima
Published: January 2020

O turismo colaborativo é uma prática cujo foco é a troca do custo da viagem pela prestação de algum tipo de serviço oferecido pelo viajante. Essa troca tem se tornado cada vez mais comum em pequenos empreendimentos hoteleiros como os hostels. O objetivo deste estudo é analisar o turismo colaborativo em hostels, tendo em vista identificar o perfil dos turistas voluntários e dos hostels, bem como vantagens e desvantagens dessa atividade para ambos. Para isso, observou-se como essa modalidade se manifesta particularmente em hostels na cidade de Curitiba/PR, onde foram realizadas entrevistas semi-estruturadas com gestores e volunturistas. O estudo multi-casos caracteriza-se como qualitativo e descritivo. Os resultados demonstraram a predominância de viajantes jovens que valorizam a experiência e acreditam que essa troca traz benefícios que poderão ser aproveitados em âmbitos profissionais. Além de valer-se dessa oportunidade para aperfeiçoar outro idioma. Por outro lado, observou-se a dificuldade dos hostels a respeito da necessidade de treinamento constante dos voluntários. Por fim, propõe-se algumas soluções para assegurar trocas mais seguras e bem-sucedidas para ambos.
A HOSPITALIDADE E A REVELAÇÃO DA HUMANIDADE. NOTAS EM MARGEM A UM PEQUENO CLÁSSICO
Authors: Maciel Josemar de Campos
Published: January 2020

O texto que segue é um ensaio que parte de um livro póstumo de Felix Tomillo Noguero, intitulado “A Hospitalidade na Bíblia e nas grandes religiões”. Ele seguirá de perto o desdobramento das ideias do texto, destacando fontes e enunciando como hipótese o título deste trabalho. O principal resultado deste esforço é uma sistematização de aspectos em que o livro contribui para renovar perspectivas, avançando na configuração de um campo de estudos atravessado pelo imperativo da hospitalidade. Tal campo possui em Noguero um de seus líderes mais destacados, por ser ele um pioneiro dos estudos do turismo. Mas a sua pesquisa aprofunda as discussões para os campos da teologia e da filosofia, entendidas à maneira clássica, e pode contribuir com insights para abrir espaço para um diálogo com as humanidades. O que acena para uma visão compreensiva e atravessada pela interpelação ética e política. A partir da exposição do movimento do texto propõe-se uma hipótese interpretativa, a saber, que Noguero vê a hospitalidade como lugar de encontro do ser humano com Deus (teofania) e consigo mesmo, como espécie perfectível (antropofania). Noutros termos, a experiência da hospitalidade revela a humanidade aos seres humanos, como desafio e como tarefa.
A LEGISLAÇÃO URBANÍSTICA DA CIDADE DE SÃO PAULO (2014-2016): DISCUSSÕES ACERCA DA HOSPITALIDADE URBANA COMO PROMOTORA DA QUALIDADE DE VIDA NA CIDADE
Authors: Silva Rafael Ferreira da , Bitelli Fábio Molinari
Published: January 2020

Este artigo buscou no Plano Diretor Estratégico (Lei nº 16.050/14) e na Lei de Parcelamento, Uso e Ocupação do Solo (Lei nº 16.402/16), conhecida como Lei de Zoneamento, ambos da cidade de São Paulo, discutir a partir dos itens descritos em seu conteúdo, a possível aderência ao conceito e às categorias da hospitalidade urbana, haja vista a busca pela qualidade de vida urbana. Mediante pesquisa exploratória de cunho qualitativo, cujo procedimento de coleta de dados foi o levantamento bibliográfico e documental, apoiou-se então na identificação dos quesitos que visam contribuir para a melhoria da qualidade da vida urbana e nos instrumentos qualificadores voltados para a valorização da escala humana. Como resultados, além dos conceitos, diretrizes, dimensões que abarcam e sugerem tais leis, foram destacados no conteúdo destes dispositivos legais, propostas que contribuem potencialmente na melhoria da qualidade urbanística, entre eles o incentivo ao uso misto de determinadas áreas, ao uso do transporte coletivo e/ou não motorizados, à valorização do uso do espaço público (seja em favor do lazer, cultura ou esporte); ao mesmo tempo em que perpassam as categorias que compreendem a hospitalidade urbana, tais como cidadania, acessibilidade, legibilidade e identidade.
Hospitalidade em sentido próprio e figurado
Authors: Gotman Anne
Published: January 2020

Neste texto de palestra de abertura de seminário realizado em outubro de 2.000, na França, sobre o tema da hospitalidade urbana, Anne Gotman parte da distinção entre o que ela chama de hospitalidade em sentido próprio,  o acolhimento pessoa a pessoa, que se refere a práticas privadas para a maioria, baseadas na obrigação de reciprocidade, da hospitalidade em sentido figurado, que se refere à ideia de hospitalidade que transparece quando dizemos que um local ou instituição é hospitaleiro (ou inospitaleiro) e que designa práticas suscetíveis de se desenvolver à margem da solidariedade e dos serviços públicos. No primeiro caso, tratam-se de situações e usos reconhecidos como tais, ainda que pouco explorados. No segundo caso, trata-se sobretudo de uma perspectiva e abordagem diferente sobre os trabalhos de pesquisa existentes que pretendemos reexaminar. A autora avança, ainda, para o conceito de hospitalidade mínima garantida, que abrange grosso modo o direito de asilo concedido a estrangeiros e antigamente aos pobres e hoje às categorias asseguráveis ou vulneráveis a quem Estado ou a comunidade fornecem proteção e segurança
Uma coleção osteológica de roedores derivada de atividades de caça da Sociedade Awá-Guajá do estado do Maranhão
Authors: Chahud Artur
Published: January 2020

Uma coleção osteológica de roedores, proveniente de depósitos de descarte alimentício da Sociedade Etnográfica Awá-Guajá, localizada no noroeste do estado do Maranhão, é examinada do ponto de vista taxonômico e tafonômico. Em relação à diversidade, entre os espécimes analisados, foram observadas, pelo menos, quatro famílias típicas da região: Dasyproctidae, Erethizontidae, Caviidae e Cuniculidae, sendo esta última a família mais comum, representada pela espécie Cuniculus paca. Com o propósito de reunir dados para a interpretação dos tipos de espécimes (adultos ou jovens) e dos processos atuantes na gênese e preservação, foram realizados estudos tafonômicos sobre seleção óssea, quebras e marcas de corte presentes. Em relação à análise tafonômica, verificou-se que o material ósseo foi acumulado em pontos próximos e não está disperso pela área analisada. Intemperismo e desgaste não foram observados, apesar de o material apresentar muitas quebras.
Formação científica de estudantes do ensino médio considerando o conhecimento popular sobre o controle de Planococcus citri (Hemiptera; Pseudococcidae)
Authors: Reis Erisnaldo Francisco , Conte Hélio
Published: January 2020

Planococcus citri (Risso 1813) (cochonilha-branca) é uma praga de plantas do gênero Citrus. Quando ocorre em grande quantidade, causa desfolhas nas plantas e queda de frutos. Esta pesquisa visou desenvolver uma atividade extracurricular com alunos do primeiro ano do ensino médio (escola estadual), para realização de um levantamento qualitativo de informações acerca do controle entomológico alternativo na área urbana da cidade de Rubim (MG), focando os biocidas para Planococcus citri. Trata-se de um estudo qualitativo e descritivo. No embasamento teórico, foram utilizados autores que estudam P. citri e que trazem concepções relacionadas aos processos de ensino e de aprendizagem. As atividades desenvolvidas consistiram em observações in natura, em laboratório, discussões, entrevistas, registros fotográficos e anotações relacionadas ao inseto. Os resultados apontam que a população da cidade de Rubim utiliza estratégias alternativas para o controle do inseto em questão. As análises e discussões realizadas pelos alunos contribuíram para o ensino e a aprendizagem de conceitos relacionados com conteúdos de Biologia e com a realidade cotidiana. Os estudantes sentiram-se estimulados, promoveram envolvimento e interações entre si e com a comunidade. Ressalta-se que os estudos em que são empregados métodos diferenciados, interagindo com recursos tecnológicos, possibilitam um aprendizado mais eficaz.
Turismo e patrimônio cultural: revisitando uma polêmica típica por meio de pratos típicos
Authors: Graeff Lucas , Zottis Alexandra Marcella
Published: January 2020

Este trabalho trata da dinamização de produtos e práticas gastronômicaspela categoria patrimônio com vistas ao turismo cultural. Trata-se de um artigocomparando as propostas de patrimonialização do menarosto e do galeto al primocanto como pratos típicos de dois municípios do estado do Rio Grande do Sul, nosul do Brasil. O argumento é de que a patrimonialização desses pratos responde àreprodução social do grupo e, por consequência, as dimensões econômica e simbólica não se contradizem necessariamente. Nos dois casos estudados, essas duas dimensões imbricam-se na produção de uma narrativa civilizacional de persistência, de duração e de um sentido identitário comum.
Behavior of parents and educators following traumatic injury to young permanent teeth of children in Joinville, Santa Catarina
Authors: Lima Jennyffer Samira de , Dalprá Jaini , Almeida Susimara Braga de
Published: January 2020

Introduction: Traumatic dental injuries are a major public health problem, especially in the age range of 7 to 15 years, when young permanent teeth are established. Objective: To evaluate the behavior of parents of children who attend public or private school and their educators, in cases of traumatic injury to young permanent teeth and to evaluate whether they sought emergency guidance, in the city of Joinville, Santa Catarina, Brazil. Evaluation was carriedout via a questionnaire for asking the parents and teachers about their knowledge of dental trauma. Material and methods: A total of 248 parents and 22 teachers participated in the study. Out of all the participants that completed the questionnaire with questions on previous trauma experience, avulsion behavior, avulsed tooth storage medium, and time elapsed from dental trauma until care, 49.6% of had higher education. The data were tabulated on a Microsoft Office Excel 365 worksheet, and the chi-square statistical test wasapplied. Results: The research showed that 91.8% of parents and8.2% of educators from both public and private schools had minimalknowledge regarding dental trauma. Many of the participants (73.2%) were unaware of what dental reimplantation was and lacked knowledge regarding storage choices for a dental element. Instead, 68% preferred to take the child to a dental surgeon to receive emergency care. Conclusion: The knowledge parents and educators of public and private schools have about dental trauma is limited. Education on this subject needs to be promoted for enabling parents andeducators to make informed decisions to ensure the best prognosis after traumatic dental injury.
Atividade antimicrobiana de extratos etanólicos de Banisteriopsis anisandra (Malpighiaceae) e interações medicamentosas Antimicrobial activity of ethanol extracts of Banisteriopsis anisandra (Malpighiaceae) and drug interactions
Authors: Ferreira Igor Valdivia , Mendes-Costa Maria Cristina
Published: January 2020

Introdução: A planta Banisteriopsis anisandra A. Juss é uma espécie medicinal pouco conhecida e estudada, mas já demonstrou potencial para utilização na odontologia. Objetivo: Avaliar a atividade antimicrobiana de B. anisandra e o potencial para interações medicamentosas com fármacos relacionados à saúde bucal. Material e métodos: Foi obtido o extrato etanólico bruto das folhas de B.anisandra, e diluições em série foram testadas contra Candida albicans (ATCC 10231), Streptococcus mutans (ATCC 25175), Streptococcus salivarius (ATCC 7073) e Staphylococcus aureus (ATCC 6538). Como controle positivo foram utilizados os antibióticos ampicilina (10 μg/ml), amoxilina (10 μg/ml) e penicilina (30 μg/ml), para as cepas bacterianas; e o antifúngico cetoconazol (2 mg/ml), para a levedura. Compararam-se a eficiência e a sensibilidade do método de difusão em meio sólido e do método de difusão em meio líquido, e foi determinada a concentração inibitória mínima (CIM), assim como foram avaliadas as interações medicamentosas dos extratos com os antibióticos. Resultados: O método de microdiluição em caldo mostrou-se mais sensível que o método de difusão em disco, sendo, portanto, mais confiável, além de usar menos quantidade de material. Houve interação medicamentosa positiva dos extratos com os antibióticos e com o cetoconazol nas concentrações de 1:2 para o extrato. A bactéria S. aureus e a levedura C. albicans mostraram-se sensíveis ao extrato da planta na diluição 1:1 nos testes de difusão em disco, e o antibiótico penicilina não se revelou eficaz em nenhuma das bactérias testadas. Conclusão: O extrato etanólico de B. anisandra tem potencial antimicrobiano e interação medicamentosa com fármacos relacionados à saúde bucal. Existem raros estudos sobre as propriedades farmacológicas de B. anisandra, e os resultados são os primeiros relatos sobre sua atividade antimicrobiana em associação com antibióticos e antifúngicos.
Removal of obturation material in endodontic retreatment: a literature review
Authors: Menezes Carina Do Nascimento , Carneiro Verydianna Frota , Vale Mônica Sampaio do
Published: January 2020

Introduction: Removal of filling material from the root canal system is required when a previous endodontic treatment fails, what may result in the permanence of an unfavorable periapical condition. The intent is to completely remove the filling material inside of the root canal to achieve sufficient cleaning and shaping for successful retreatment. Objective: The aims of this article were to provide asystematic review of the different techniques of endodontic filling material associated or not with organic solvents and to analyze them critically in terms of advantages and disadvantages of each technique. Literature review: The descriptors used were “guttapercha”, “obturation,” and “retreatment” in the following databases: PubMed, MEDLINE, Latin American and Caribbean Center on Health Sciences Information (Bireme), Latin-American and CaribbeanHealth Sciences (Lilacs), Brazilian Dentistry Bibliography (BBO), and Scientific Electronic Library Online (SciELO). Publications of in vitro/ ex vivo and in vivo experiments without language restriction between the years 2010 and 2018 were selected. Conclusion: None of the techniques were capable of performing complete root canal cleaning, and the manual method was so effective as the automated method, although it requires longer working time. Furthermore, although this review confirmed that the solvent action did not allow a significantimprovement in the removal of the filling material, ultrasoundactivated irrigation proved to be an efficient adjunctive device as it could significantly reduce the volume of intracanal residuals.
Rânula mergulhante extensa em paciente pediátrico tratado com micromarsupialização: relato de caso Extense plunging ranula in pediatric patient treated with micro-marsupialization: a case report
Authors: Gonçalves Kalyne Kelly Negromonte , Santos Marcelo Soares dos , Alves Silva Joana De Ângelis , Lira Correia Andreza Veruska
Published: January 2020

Introdução: O termo rânula é usado para descrever um aumento de volume difuso no assoalho da boca causado por um extravasamento mucoso ou um cisto de retenção de muco derivado das principais glândulas salivares sublinguais ou submandibulares. A rânula pode ser simples ou mergulhante, quando a pressão do fluido disseca através do músculo milo-hioideo para o espaço submandibular.Objetivo: Relatar um caso de rânula mergulhante extensa em paciente pediátrico tratado por micromarsupialização. Relato de caso: Criança do sexo masculino compareceu ao Hospital da Restauração, Recife (PE), com queixa de tumefação intraoral, submentual e submandibular esquerda com evolução de uma semana. Observou-se extenso aumento de volume em região de soalho bucal de cor azulada, textura lisa e com foco central ulcerado. Com base nos aspectos clínicos e imaginológicos e na história da doença, o diagnóstico de rânula mergulhante foi realizado. Optou-se pela técnica de micromarsupialização, sob anestesia local, com utilização de fio reabsorvível à base de poliglactina. Paciente segue em acompanhamento de seis meses, sem sinais de recidiva da lesão. Conclusão: Visando a um procedimento mais simples e de baixa morbidade, a micromarsupialização mostra-se uma alternativa de tratamento viável e com bons resultados quando bem indicada, principalmente em crianças.
Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure
Authors: Segaran Renu Chandra , Chan Li Yun , Wang Hong , Sethi Gautam , Tang Feng Ru
Published: January 2020

Radiation exposure may induce Alzheimer's disease (AD), depression or schizophrenia. A
number of experimental and clinical studies suggest the involvement of miRNA in the development
of these diseases, and also in the neuropathological changes after brain radiation exposure. The current
literature review indicated the involvement of 65 miRNAs in neuronal development in the brain.
In the brain tissue, blood, or cerebral spinal fluid (CSF), 11, 55, or 28 miRNAs are involved in the
development of AD respectively, 89, 50, 19 miRNAs in depression, and 102, 35, 8 miRNAs in
schizophrenia. We compared miRNAs regulating neuronal development to those involved in the
genesis of AD, depression and schizophrenia and also those driving radiation-induced brain neuropathological
changes by reviewing the available data. We found that 3, 11, or 8 neuronal developmentrelated
miRNAs from the brain tissue, 13, 16 or 14 miRNAs from the blood of patient with AD, depression
and schizophrenia respectively were also involved in radiation-induced brain pathological
changes, suggesting a possibly specific involvement of these miRNAs in radiation-induced development
of AD, depression and schizophrenia respectively. On the other hand, we noted that radiationinduced
changes of two miRNAs, i.e., miR-132, miR-29 in the brain tissue, three miRNAs, i.e., miR-
29c-5p, miR-106b-5p, miR-34a-5p in the blood were also involved in the development of AD, depression
and schizophrenia, thereby suggesting that these miRNAs may be involved in the common
brain neuropathological changes, such as impairment of neurogenesis and reduced learning memory
ability observed in these three diseases and also after radiation exposure.
Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy
Authors: Zhu Shunqin , Yu Qin , Huo Chunsong , Li Yuanpeng , He Linshen , Ran Botian , Chen Ji , Li Yonghao , Liu Wanhong
Published: January 2020

Background:

Artemisinin is a sesquiterpene lactone compound with a special peroxide
bridge that is tightly linked to the cytotoxicity involved in fighting malaria and cancer. Artemisinin
and its derivatives (ARTs) are considered to be potential anticancer drugs that promote cancer cell
apoptosis, induce cell cycle arrest and autophagy, inhibit cancer cell invasion and migration. Additionally,
ARTs significantly increase intracellular Reactive Oxygen Species (ROS) in cancer cells,
which result in ferroptosis, a new form of cell death, depending on the ferritin concentration. Ferroptosis
is regarded as a cancer suppressor and as well as considered a new mechanism for cancer therapy.

Methods:

The anticancer activities of ARTs and reference molecules were compared by literature
search and analysis. The latest research progress on ferroptosis was described, with a special focus on
the molecular mechanism of artemisinin-induced ferroptosis.

Results:

Artemisinin derivatives, artemisinin-derived dimers, hybrids and artemisinin-transferrin
conjugates, could significantly improve anticancer activity, and their IC50 values are lower than those
of reference molecules such as doxorubicin and paclitaxel. The biological activities of linkers in dimers
and hybrids are important in the drug design processes. ARTs induce ferroptosis mainly by
triggering intracellular ROS production, promoting the lysosomal degradation of ferritin and regulating
the System Xc-/Gpx4 axis. Interestingly, ARTs also stimulate the feedback inhibition pathway.

Conclusion:

Artemisinin and its derivatives could be used in the future as cancer therapies with
broader applications due to their induction of ferroptosis. Meanwhile, more attention should be paid
to the development of novel artemisinin-related drugs based on the mechanism of artemisinininduced
ferroptosis.
LITERATURE STUDY: VALIDITY AND RELIABILITY TEST OF MASLACH INSTRUMENTS BURNOUT INVENTORY-HUMAN SERVICES SURVEY (MBI-HSS) IN NURSES IN SEVERAL COUNTRIES
Authors: Fauzia Liza , Erika Kadek Ayu , Irwan Andi Masyitha
Published: January 2020

Burnout Syndrome is one of the most vulnerable psychological problems occurring in nurses in hospitals. The incidence of burnout syndrom in nurses, if it is allowed to be untreated specifically, it will affect on work productivity, physical and psychological disorders. Therefore, it is important to identify nurses who are at risk in developing the burnout syndrome. To identify this, a valid and reliable instrument is needed so that the data obtained is accurate. The aim of this study literature was to identify the value of the validity and reliability of the Maslach Burnout Inventory-Human Service Survey (MBI-HSS) instrument in several countries in measuring burnout syndrome of nurse. The databases used in this literature study were PubMED, Science Direct and Google Schoolar. There were 21 articles identified and published from 2010-2017. Of the 21 articles, 5 articles met the inclusion criteria. The results showed that the value of validity and reliability were good enough, from the results of the validity test, the three-factor analysis was considered the best analysis among the other factor analyzes that produced acceptable model fit values and items that had a validity value below the standard were 20 items (deleted items12 and 16), Lebanon 20 items (deleted items 13 and 22), Sri Lanka 21 items (deleted item 4), South Africa 20 items (deleted items 4 and 6), and France 17 items (deleted 12,16,6,22,13) while the reliability of the MBIHSS instrument in some countries shows the reliable value with cronbach alpha > 0.70. In conclusion the value of validity and reliability of the instrument shows the accuracy in collecting data. With the value of validity and reliability of the MBI-HSS instrument, it is expected to help practitioners and other researchers in identifying the accuracy of the MBI-HSS instrument in measuring the burnout syndrome of nurses.
THE RELATIONSHIP BETWEEN THE ABILITY TO PERFORM ACTIVITIES OF DAILY LIVING WITH RISK FOR FALLS AMONG OLDER ADULTS IN TRESNA WERDHA SOCIAL SERVICE BANYUWANGI
Authors: Nisa Luthfi Fadlilatun , Aini Latifa , Rosyidi Kholid
Published: January 2020

Increasing number of older adults makes them less productive which causes a decline in their independence to perform the activities of daily living. One of the physical problems that causes morbidity and mortality among older adults is fall. The purpose of this research was to analyse the relationship between the ability to perform activities of daily living and risk for falls among older adults in Tresna Werdha Banyuwangi. This research applied non experimental correlational design and cross sectional approach. The objects of research were 71 older adults. The sample was taken using total sampling which was comprised of 65 older adults that fulfilled inclusion criteria. Katz Index, Morse Fall Scale (MFS), and observation sheet were used to collect the data. Those data analysed using chi square test. The result of the older adults ability in performing activities in daily living showed that categorised as mild and the mildest dependent 17 older adultsÂ  (26,1%)Â  with low and high risk of falls were. Test resulted in p value 0,002 (p <Î± = 0,05) which suggested that there was a relationship between the ability to perform activities of daily living and risk for falls. Medical staff are expected to provide nursing care in addressing risk for falls, providing ambulatory aidÂ  to help maintaining balance while walking, teaching the patients what to do when they fall, so they donâ€™t suffer serious injury, by monitoring the movement, and by holding a routine physical program.Â
Duped by an ass: Revisiting the chronology of Apuleius’ Metamorphoses
Authors: Lewis Enlli
Published: January 2020

In this paper I intend to revisit the established chronology of the Metamorphoses. I will be arguing that an ellipsis of nearly a year occurs following Charite’s wedding at 7.14, a period presumed to span merely a few weeks heretofore in Apuleian studies. Prompted by this discovery, I will conduct a re-evaluation of how Lucius handles time within his narrative by comparing this ellipsis with similar instances of temporal distortion in the novel. I will conclude by claiming that this ellipsis is a version of a temporal topos familiar from Greek romance novels, which further serves to strengthen the analogies between Lucius’ initiation and the weddings of Charite and Psyche. Both the theoretical approach and terminology employed in this paper draw primarily from Gérard Genette’s Narrative Discourse (1980) and Mieke Bal’s Narratology ([1985]2009). I will be following the scholarly edition by Robertson ([1940-1945]1985-1992), but will also note any discrepancies between scholars which are relevant to my argument.