bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep learning segmentation model produces accurate biodiversity predictions at 10 m spatial resolution
Authors: Andermann Tobias , Häggmark Johan , Olsson Patrik , Högström Alice
Published: September 2024

Biodiversity loss is an increasingly intensifying global crisis with significant societal, political, and financial implications. However, our understanding of biodiversity remains limited due to vast data gaps, and the existing data products fail to meet the needs of decision-makers because of their limited accuracy, spatial scale, and resolution. As we approach the short- to medium-term implementation deadlines of major international biodiversity agreements, such as the United Nation's Kunming-Montreal Global Biodiversity Framework and the European biodiversity strategy, there is a pressing need for high-quality data products to guide large-scale conservation prioritization decisions. In this study, we present a novel deep learning segmentation approach for detecting high biodiversity-conservation-value forests using a set of remote sensing data products. This approach has enabled us to produce a national data product of continuous coverage for Sweden, with an unprecedented accuracy of 91% and a high-detail spatial resolution of 10-meter pixel size, significantly advancing on existing approaches. Sweden serves as a good test case for the here developed approach, as it is home to the largest portion of Europe's remaining old-growth forests and is also characterized by robust biodiversity and environmental data availability. Our approach allowed us to map over 50,000 km² of high conservation value forest (HCVF) at high confidence, saving more than 750 years of manual inventory effort and significant financial and personnel resources. With its high accuracy and spatial resolution, our data product offers substantial utility for decision-makers at different administrative scales, and directly addresses the goals set by large international biodiversity conservation plans. While this study focuses on detecting high conservation value forests in Sweden, the presented model serves as a proof-of-concept implementation that can be adapted and applied for modeling other regions and biodiversity metrics.
Is basic training in palliative care sufficient to guarantee the improvement of knowledge and skills in this area? – medical knowledge assessment study
Authors: Monteiro Rita , Ribeiro Hugo , Dourado Marília
Published: September 2024

Background: With the increase in the population needing Palliative Care, it is necessary to increase and improve the supply of this care in Portugal. Throughout doctors' pre-graduate training, there are few learning opportunities in this area, making it necessary to resort to further training to improve the knowledge and skills needed to guide patients at the end of their lives. Studies carried out on doctors and medical students showed a clear need to improve training. Others observed a clear benefit in interns who underwent postgraduate training in the area, in dealing with patients at the end of their lives.
The objective is to evaluate the impact of a basic training action on the palliative care knowledge obtained by medical doctors.
Methods: Observational and cross-sectional study, carried out by sharing a questionnaire with the 204 participants enrolled in the “Intensive Palliative Medicine Course” organized by a group of doctors in November 2021. The questionnaire was completed by participants at three moments of the training (before, immediately after the course and 6 months after the course), which contained questions to assess theoretical knowledge and the skills and abilities obtained.
Results: 209 responses were collected, 93 (45.58%) doctors responded before training, 80 (39.21%) immediately after training and 36 (17.64%) six months after training. After the training, an improvement in knowledge was observed (p=0.014), which does not appear to have persisted six months after the course (p=0.574). However, six months after training, an increase in doctors' confidence in referring patients to Palliative Care Teams or Units (p=0.009) and in medicating patients who may be in the last months of their lives (p=0.005) was observed.
Conclusions: The results of theoretical knowledge in medical areas were worse, so it may be necessary to create more specific training opportunities for the medical profession. An increase in doctors' self-confidence in referring and medicating patients with Palliative Care needs was observed, which may be associated with better medical care provided. It is necessary to carry out more studies to evaluate the impact of combined theoretical and practical training on the knowledge of doctors in PC.
Access to Mental Health Care and Navigating Psychological Distress: A Cross-sectional Study Among Bangladeshi University Students
Authors: Begum Momotaj , Muniruzzaman Md.
Published: September 2024

University students often face high mental health challenges but rarely seek treatment, leading to distress and suicidal behavior. This study addresses this gap by examining the prevalence, risk factors, and accessibility of mental health care among Bangladeshi university students. A total of 267 samples were collected from three different Bangladeshi universities through face-to-face interviews, gathering socio-demographic, health, and behavior variables, along with data using the Kessler Psychological Distress Scale (K10). The results indicate that, approximately just over a quarter reported psychological distress (30.3%). Risk factors for psychological distress among university students included coming from joint families, living in university halls, being financially self-supported, not regularly engaging in religious practices, having insomnia, feeling uncomfortable discussing mental health issues with friends, having moderate social support, and facing significant challenges in overcoming psychological distress. The findings will help in implementing university-based mental health programs, increasing awareness, reducing stigma, enhancing access to professional care, including suicide prevention, and providing baseline data for future research.
Exploring the relationship between Mental Health Issues and Academic Performance of Undergraduate Students in a Ghanaian Tertiary Institution: a cross-sectional study.
Authors: Arthur Andrew , Fraikue Joanne , Adu-Amankwah Bijoux , Ofori Richard , Sekyi Dorcas , Boateng Abena Afrakomah , Asamoah Elsie , Appiah Seth Christopher Yaw
Published: September 2024

Background
Mental health associations with students’ academic outcomes are critical for students’ well-being and excellent performance, particularly among tertiary students in their educational trajectory. This study investigated the relationship between mental health incidence and academic performance among university students in a public university in Ghana. Additionally, we study students’ level of mental health awareness.
Methods
The study adopted a quantitative study with an analytical cross-sectional design. Through the multistage sampling technique, structured questionnaires were administered to 384 undergraduate students at Kwame Nkrumah University of Science and Technology (KNUST). Data management and analysis were performed using SPSS v.27. Descriptive data are presented in tables and reported as frequencies. Inferential analysis was conducted using a multilevel logistic regression model and a p-value of 0.05 was considered to indicate statistical significance.
Results
Severe depression (p = 0.016, ϰ2=0.784) was significantly associated with students’ academic performance. Severe anxiety (p = 0.020, ϰ2=11.700), gender (p = 0.014, ϰ2=5.999) and self-efficacy (p = 0.015, ϰ2=5.939), were found to have a statistically significant association with academic performance (p < 0.05). According the multilevel analysis, females experiencing mental health had reduced likelihood of achieving high academic performance compared to male students (AOR = 0.343, 95% CI = 0.144–0.813, p = 0.015). Severely depressed students (AOR = 0.264, 95% CI = 0.084–0.830, p = 0.23) are significantly less likely to increase their Cumulative Weighted Average (CWA). Self-efficacious students (AOR = 3.325, 95% CI = 1.421–7.784, p = 0.06) were three times more likely to increase their CWA.
Conclusion
Severe depression causes a reduction in students’ academic performance, while high academic self-efficacy among students serves as a protective factor by facilitating an increase in students’ CWA when they encounter mental health issues.
Thickness Accommodation in Earwig Fan Folding
Authors: Kitajima Chisaki , Saito Kazuya , Taiju Yoneda , Nishi Koki , Suehiro Kaoru
Published: September 2024

Origami embodies a traditional aspect of art culture. This technique facilitates the compact folding of deployable structures and improves construction and transportation performance in engineering. While these advantages are attractive, designing deployable structures is complex because it requires consideration of material thickness. Here we introduce the thickness accommodation techniques into the highly efficient folding patterns derived from biomimetic engineering approach. The underlying simple geometrical elements within the complex crease patterns of earwig hindwings were already revealed, and design software was implemented to customize the pattern using an algorithmic design tool. However, the crease pattern has a zero thickness, and the thickness accommodation should be performed for engineering applications as a deployable structure. We propose thickness accommodations for two folding modes with mountain and valley folding line assignments. For each folding mode, the thickness accommodation solves the interference, and we make a model made of thick materials to verify the deployment behavior. The research results represent a further step toward developing biomimetic engineering applications using origami techniques based on the crease patterns of earwig hindwings.
Fe3O4@HA-Cu(OAc)2 nanocomposite as a nanomagnetic water-compatible catalyst for efficient synthesis of 1,2,3-triazoles in water
Authors: Arjmandzadeh Beheshteh , Jafari Abbas Ali
Published: September 2024

A new Humic acid-based nanomagnetic copper(II) composite was prepared and used as an eco-friendly recoverable catalyst for the synthesis of 1,4-disubstituted 1,2,3-triazoles via the three-component click reaction of alkyl halide, sodium azide, and terminal alkyne in good to excellent yield. A simple magnetic copper acetate composite preparation using humic acid, Fe3O4@HA-Cu(OAc)2, was reported and characterized by SEM, TEM, XRD, EDX, VSM, AAS, and FT-IR. The catalyst shows high catalytic potential in a one-pot three-component click reaction for synthesizing 1,2,3-triazoles. The nanomagnetic Fe3O4@HA-Cu(OAc)2 demonstrates highly efficient, stable, compatible with oxygen/water and recyclable copper (II), and cost-effectiveness advantages catalyst. An external magnetic field easily recovers the catalyst, and therefore, time and energy are saved since no filtration or decantation technique was needed. According to high dispersibility in water, nanomagnetic Fe3O4@HA-Cu(OAc)2 can be utilized as a highly efficient catalyst.
Effects of HNTX-VII on Kv4.2 and Kv4.3 and Molecular Determinants of Kv4.3 Interacting with HNTX-VII
Authors: Chen Bo , Hu Zhaotun , Renzhong Chen , Juan He , Zeng Xiongzhi
Published: September 2024

HNTX-VII is a novel peptide isolated and purified from the venom of the Chinese spider Ornithoctonus hainana, with a relative molecular mass of 3830.973 Da. Electrophysiological experiments have demonstrated that HNTX-VII exhibits minimal effects on TTX-S, TTX-R, and delayed rectifier potassium channels on dorsal root ganglia (DRG), as well as on Kv1.4 and Kv4.1. However, it significantly inhibits Kv4.2 and Kv4.3 currents, with IC50 values of 299.6 ± 6.48 nM and 114.5 ± 5.36 nM, respectively, for Kv4.2 and Kv4.3. The sequence of HNTX-VII, determined by Edman degradation, is ECRYWLGTCSKTGDCCSHLSCSPKHGWCVWDWT. Composed of 33 amino acids and containing 3 pairs of disulfide bonds, this molecule represents a typical inhibitor cystine knot (ICK) motif. Furthermore, HNTX-VII alters the kinetic properties of Kv4.2 and Kv4.3 channels by causing corresponding shifts in their steady-state activation, steady-state inactivation, and inactivation recovery curves. To further investigate the molecular mechanism underlying the interaction between HNTX-VII and Kv4.3 channels, 19 mutants in the extracellular loops of the S1-S2 and S3b-S4 segments of the Kv4.3 channel were designed and constructed using site-directed mutagenesis. Electrophysiological techniques were then employed to assess the inhibitory activity of HNTX-VII against these mutants. Notably, the V282A mutant in the S3b-S4 loop exhibited the most significant reduction in sensitivity to HNTX-VII, with an IC50 value 5.37 times that of the wild-type channel. Therefore, it is inferred that the 282nd amino acid in the extracellular loop of S3b-S4 serves as a crucial site for the interaction between HNTX-VII and Kv4.3.
Investigate the predictivity of human Reconstructed Intestine Micronuclei Cytome (RICyt) assay in genotoxic hazard identification
Authors: Lim Hui Kheng , Hughes Christopher Owen , Landry Timothy , Tan Choon Wee Joseph , Ayehunie Seyoum , Smith Benjamin Paul Chapman
Published: September 2024

While valuable for hazard identification, in vitro genotoxicity tests that are conducted in 2D monolayer cell cultures possess limitations to accurately envisage in vivo outcomes and may result in unnecessary follow-up in vivo studies. One limitation is their relevance to actual human exposure and the assessment of genotoxicity in tissues representative of “sites-of-first-contact” with genotoxic agents. The revised OECD testing guidelines had emphasized the need for considering site-of-first-contact effect and should be included when carrying out genotoxic hazard investigations. Till date, only in vivo studies can adequately address the oral/gastrointestinal route of exposure and there exists no validated in vitro assay for the gut for ingestible materials. Previously, we described the development of a new human Reconstructed Intestine Micronuclei Cytome (RICyt) assay using EpiIntestinal™ microtissues for site-of-contact genotoxic hazard identification of orally ingested materials. The human small intestine is where approximately 90% of the digestion and adsorption of food occurs and a major exposure site of ingested genotoxicants, thus a key site for evaluation. Here, we have conducted an investigation on the predictive performance of the RICyt assay. The assay platform was challenged with a training set of 16 test materials which include standard reference genotoxins and non-genotoxins as well as food relevant substances with various mode of actions. The overall RICyt accuracy was 92.9% with sensitivity of 83.3% and specificity of 100%. Majority of the test materials were correctly identified during this within-laboratory investigation though yielded one false negative and two equivocal outcomes. These results emphasize that the RICyt assay in EpiIntestinal™ microtissues has adequate predictivity and is a promising in vitro tool for genotoxic hazard identification of orally ingested substances.
Knowledge, Attitude, and Willingness to accept the RTS, S malaria vaccine among Mothers/Caregivers of under-five children: A Qualitative study in Enugu state, Nigeria
Authors: Iloabuchi Francis Chibuike , Chima Uzochukwu Emmanuel , Umeh Anthony Uche , Okafor Pauline Nnedimma , Ngige Amauche Pearl , Anene-Okeke Chigozie Gloria
Published: September 2024

Background
Malaria remains a significant public health challenge in Nigeria, particularly among children under the age of five. This study investigated the knowledge, attitudes, and willingness to accept the RTS, S malaria vaccine among mothers and caregivers of children under five years of age in Enugu State, Nigeria.
Methods
A descriptive cross-sectional survey design was employed, involving 405 participants who visited two major tertiary hospitals in Enugu State, Nigeria. Data were collected via structured questionnaires, checked, coded, and entered into the Microsoft Excel package 2021 and exported to Statistical Product and Service Solutions (SPSS) version 27 for descriptive and inferential statistical analysis.
Results
A total of 66.2% of the respondents demonstrated good knowledge about malaria and the RTS, S malaria vaccines, whereas only 55.1% exhibited a positive attitude toward vaccination. Despite this, a notable gap was identified, with only 51.6% of participants willing to accept the RTS, S malaria vaccine for their children. Factors significantly influencing vaccine acceptance included the caregiver’s gender, age, marital status, educational level, and place of residence.
Conclusion
These findings highlight the critical need for targeted educational campaigns and interventions to address misconceptions and improve awareness of the benefits and safety of the RTS, S malaria vaccine. Enhancing the knowledge and attitudes of mothers and caregivers is essential to increase vaccine acceptance and ultimately reduce the malaria burden among children in Enugu State. To achieve these goals, collaborative efforts between healthcare providers, government agencies, and community organizations are recommended.
Trial Registration
Not applicable
Using Positive Deviance to Enhance HIV Care Retention in South Africa: Development of a Compassion-Focused Programme to Improve the Staff and Patient Experience
Authors: Ober Allison , Skinner Donald , Bogart Laura , Busakwe Leletu , Davids Wadene , Mahomed Hassan , Ling Debbie , Zweigenthal Virginia
Published: September 2024

Background
HIV burden remains high in South Africa despite intensive efforts to curtail the epidemic. Public primary care facilities, where most people with HIV (PWH) in South Africa receive treatment, face myriad challenges retaining patients on antiretroviral therapy (ART). Nevertheless, some facilities manage to consistently retain PWH in care. We used a participatory Positive Deviance (PD) approach to discover characteristics of primary care facilities with above-average 12-month retention rates to develop an intervention. PD is an asset-based approach to behavior change that consists of discovering how high-performing outliers succeed despite sizable barriers, and then using those data to develop interventions for low-performers.
Methods
We conducted 11 in-depth leadership interviews, 9 staff focus groups with 29 participants, 11 patient focus groups with 45 participants, 23 patient shadowing visits, and 3 clinic observations in each of 3 high- and 3 low-retention public primary care facilities in Cape Town, South Africa, to discover characteristics of high-retention facilities that might be contributing to higher retention rates.
Results
Themes found to a greater degree in high-retention facilities were compassionate, respectful, patient-centered care; higher staff morale, passion for the work and team cohesion; efficient workflow procedures; and a welcoming physical environment. From these themes we developed the Connect intervention, consisting of strategies within three domains: (1) Engage, encourage, and support staff (e.g., a monthly staff support huddle, a compassion training); (2) Expedite and augment workflow procedures (e.g., adjust folder system to lower wait times); (3) Create a welcoming physical environment (e.g., fresh paint and plants in the waiting area).
Conclusions
A PD approach enabled us to identify factors that could be contributing to higher ART retention rates within low-resource public sector primary care facilities in Cape Town, South Africa. If effective, Connect could be a feasible, affordable complement to existing programmes aimed at improving care for PWH.
Toxicity assessment of doxycycline-aided artificial intelligence-assisted drug design targeting candidate 16S rRNA methyltransferase gene
Authors: Mubeen Hira , Rafiq Nagina , Khan Madiha , Jabeen Saima , Shoaib Muhammad Waseem
Published: September 2024

Background
The misfunction of the protein 16SrRNA methyltransferase usually results in Urinary tract (UTI), and Gastrointestinal (GI) infections, sepsis, pneumonia, and also cause wound infections. It confers resistance to aminoglycoside medications, which complicates the treatment of infections caused by these bacteria.
Objectives
Herein, we aim to investigate the role of artificial intelligence (AI) in medical sciences to provide the solutions as a significant need in medical therapy for infections.
Methodology: Using an AI drug design tool, three effective de novo medicinal compounds that target the 16SrRNA methyltransferase protein were discovered. The computational tools used includes: Expasy for protein annotation, Protparam to calculate physiochemical parameters, SWISS-MODEL to estimate the 3D structure, and Uniprot to generate the 16SrRNA methyltransferase protein sequence. An adequate foundation for the development and validation of AI-designed phytochemical medicines for infections is provided by quality assessment, binding site prediction, drug design with WADDAICA, toxicity screening, ADMET evaluation, and docking analysis with CB-dock.
Results
Comprehensive pharmacokinetic and toxicology analyses provided the non-toxic character of AI-designed doxycycline by demonstrating its exceptional absorption in the blood–brain barrier. The AI-designed doxycycline docks with the 16SrRNA methyltransferase protein with a noteworthy affinity of about − 7.6 kcal/mol, indicating potential therapeutic value.
Conclusion
Even though the in silico studies show efficacy and safety, still there is need of in vivo trials to investigate the hidden medical aspects. By addressing existing constraints, this work considerably expands the knowledge about newer methods and also helps to understand deep insights of dug design mechanism for treatment.
Antenna Array and Front End Design for GNSS to Cancel Low Elevation Jamming Signals
Authors: yigit olcay
Published: September 2024

In this study, we propose antenna array and a front-end design to mitigate jamming signals coming from low elevation angles without changing the receiver system. Many navigation systems based on terrestrial signals assume that jamming signals are at low elevation angles. There is a need for a feedback system that detects the presence of interference signals and switches to an interference-resistant mode by activating switches. Signals in the range of 750 MHz to 2 GHz are observed without interference with our designed system. The system receives signals at levels close to -70 dBm for frequencies outside the GNSS band, while signals received within the GNSS band from GPS, Galileo, and GLONASS satellites are close to -130 dBm. Without jamming signals, the C/N value of the received navigation signals is 25–30 dB. When jamming signals are present, C/N values drop to 10 dB. The designed system was tested in both laboratory and open field environments. When the system sense jam signals, it switches to array mode in127 micro seconds, and cancel the jam signals about 30 dB.
Research on Control Strategies for High Center of Gravity, High Curvature 4WS Vehicles on Non-Rigid Pavements
Authors: Yang Xu , Deng Xinxian , Lei Yu , Zhong Shengchi , Huang Bin
Published: September 2024

Autonomous driving technology is not only widely used for open vehicles on municipal roads but also for special equipment in low-speed scenarios such as logistics distribution, sanitation cleaning, sightseeing shuttles, and smart farming. However, in the unique scenarios of farmland and the special structure of unmanned agricultural machinery, autonomous vehicles still face complex control issues such as high curvature steering, non-rigid road surfaces, and high centers of gravity, which severely affect the tracking and stability performance of the vehicles. To address these problems, this paper proposes a path tracking stability control strategy that considers the tracking performance of vehicles during high curvature steering at medium and low speeds, as well as the impact on vehicle stability caused by vehicle tilting due to a high center of gravity and the tendency of vehicles to sink in farmland scenarios. By integrating the Model Predictive Control (MPC) algorithm and improving the fuzzy control algorithm, a 4WS vehicle kinematic model and a lateral stability model under non-rigid road conditions were established. A comprehensive control method that considers vehicle stability and turning path tracking accuracy was proposed. Simulation comparisons using Simulink show that the 4WS vehicle control strategy proposed in this paper has better tracking performance and stability compared to traditional 2W tracking control methods. Experiments conducted on an intelligent driving soil sampling vehicle validated the advantages of the proposed control strategy in terms of high center of gravity, high curvature steering control accuracy, and stability.
A Novel Approach to PMSG-Based Wind Energy Conversion with Power Factor Correction and Efficient DC-DC Conversion
Authors: Sundaramoorthy Selvaperumal , ML Ramamoorthy
Published: September 2024

A novel wind energy conversion system (WECS) utilizing a Permanent Magnet Synchronous Generator (PMSG) followed by an active front end rectifier (AFE) which is followed by a Partial Resonant Inverter (PRI) based AC link DC-DC converter delivering power to DC link of the DSTATCOM is proposed in this work. The control scheme takes care of maximum power point tracking by adjusting speed of PMSG depending upon the prevailing wind velocity. The three phase PMSG side current is forced to be sinusoidal and at unity power factor with respected to the instantaneous PMSG terminal voltage by using the AFE rectifier. This proposed system is discovered to be superior to typical DBR based rectifier in terms of the reduced THD of the source current leading to more power conversion efficiency. PRI exhibit zero voltage switching which offers high voltage gain. This outlined concept is modelled in MATLAB/SIMULINK which has been simulated. The suggested concept is validated by the simulation results.
Next-Gen LH2 Transportation: Extending Dormancy Period to 400 Days with Highly Effective MOF Adsorbents
Authors: Oh Hyunchul , PARK JAEWOO , Ha Junsu , Lee Hong Kyu , Kim Hyunlim , Jung Sungyeop , Jung Minji , Park Taeung , Jiménez-Ruiz Mónica , Russina Margarita , Moon Hoi Ri , Park Jitae
Published: September 2024

Liquid hydrogen (LH2) offers high energy density but faces challenges like boil-off losses (3-15% per day) due to its cryogenic temperature, limiting its use in long-term storage and transportation. In this study, we explore the use of metal-organic frameworks (MOFs), specifically MIL-53 and IRMOF-20, to enhance hy-drogen (H2) long-distance transportation by mitigating H2 boil-off losses. Our results show that these MOFs can achieve an adsorption capacity of up to 97% of the volumetric capacity of a traditional LH2 tank. This significant adsorption capacity extends the dormancy period of LH2 from 83 to 407 days, demonstrating the MOFs' effectiveness in mitigating boil-off losses. The super-dense H2 adsorption, which remains rela-tively stable up to 35 K, may closely resemble the conditions of solid H2, leading to increased H2-H2 inter-actions and enhanced sorption capacity. These findings highlight the potential of MOFs to improve the ef-ficiency and sustainability of cryogenic H2 storage, advancing H2's role as a sustainable energy carrier.
Collaborative Mixture of Experts for Enhanced Code-Switching Visual Recognition Through Recursive Token Propagation
Authors: Nisapo Liam , Garcia Daniel , Williams Olivia , Prence Taylor
Published: September 2024

Multilingual environments often require models to accurately recognize and process both linguistic and visual inputs, particularly in cases where code-switching occurs frequently. Traditional models designed for language and visual recognition struggle to handle such complexities due to their inability to dynamically allocate resources to specific tasks. The introduction of a Collaborative Mixture of Experts (MoE) model within Mistral 8x7b addresses this limitation through the implementation of expert modules that specialize in different aspects of code-switching and visual recognition. A dynamic gating mechanism selects the most appropriate expert based on the input, leading to substantial improvements in precision, recall, and cross-modal accuracy. Experimental results demonstrate that the MoE architecture not only enhances linguistic boundary detection in multilingual contexts but also significantly improves the alignment between language and visual data, ensuring more robust and adaptive performance in real-time applications. The findings indicate that the proposed model outperforms baseline models in both accuracy and computational efficiency, suggesting its potential for further advancements in handling complex multimodal tasks.
A Blueberry (Vaccinium L.) Crop Ontology to Enable Standardized Phenotyping for Blueberry Breeding and Research
Authors: Hislop Lillian M. , Luby Claire H. , Loarca Jenyne , Humann Jodi , Hummer Kim E. , Bassil Nahla , Zhao Dongyan , Sheehan Moira J. , Casa Alexandra M. , Billings Grant T. , Echeverria Daniella M. , Ashrafi Hudson , Babiker Ebrahiem , Edger Patrick , Ehlenfeldt Mark K. , Hancock Jim , Finn Chad , Iorizzo Massimo , Mackey Ted , Muñoz Patricio R. , Olmstead James , Rowland Lisa J. , Sandefur Paul , Spencer Jessica A. , Stringer Stephen , Vorsa Nicholi , Wagner Adam , Hulse-Kemp Amanda M.
Published: September 2024

Breeding programs around the world continually collect data on large numbers of individuals. To be able to combine data collected across regions, years, and experiments, research communities develop standard operating procedures for data collection and measurement. One such method is a crop ontology, or a standardized vocabulary for collecting data on commonly measured traits. The ontology is also computer readable to facilitate the use of data management systems such as databases. Blueberry breeders and researchers across the United States have come together to develop the first standardized crop ontology in blueberry (Vaccinium spp.). We provide an overview and report on the construction of the first blueberry crop ontology and the 178 traits and methods included within. Researchers of Vaccinium species—such as other blueberry species, cranberry, lingonberry, and bilberry—can use the described crop ontology to collect phenotypic data of greater quality and consistency, interoperability, and computer readability. Crop ontologies, as a shared data language, benefit the entire worldwide research community by enabling collaborative meta-analyses that can be used with genomic data for quantitative trait loci, genome-wide association studies, and genomic selection analysis.
PENGARUH MEDIA SOSIAL DAN GAME ONLINE TERHADAP AKHLAK SISWA DI MADRASAH ALIYAH MASYARIQUL ANWAR CARINGIN
Authors: Alauddin Firman , Wasehudin Wasehudin , Haetami Zikri Alwi
Published: September 2024

Tujuan penelitian ini, untuk mengetahui: (1) Pengaruh media sosial terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin, (2) pengaruh game online terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin, (3) pengaruh media sosial dan game online terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin, Jenis penelitian yang digunakan penelitian ini adalah asosiatif. Teknik pengambilan sampel yang digunakan pada penelitian ini adalah teknik simple random sampling, yaitu teknik pengambilan sampel yang memberikan peluang yang sama bagi setiap unsur (anggota) populasi untuk dipilih menjadi anggota sampel. Selanjutnya untuk mendapatkan pengaruh sosial media dan game online terhadap akhlak siswa peneliti menggunakan pengujian validitas dan reliabilitas yang dilakukan dengan menggunakan software SPSS 26.0. Hasil penelitian  menunjukkan bahwa; (1) Hasil pengujian menunjukkan bahwa media sosial berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. Hal tersebut dibuktikan berdasarkan hasil uji t dengan nilai sig sebesar 0,000 < 0,05 sehingga H01 ditolak dan Ha1 diterima. Jadi dapat disimpulkan bahwa media sosial berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. (2) Hasil pengujian menunjukkan bahwa game online berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. Hal tersebut dibuktikan berdasarkan hasil uji t dengan nilai sig diperoleh nilai 0,000 < 0,05 sehingga H02 ditolak dan Ha2 diterima. Jadi dapat disimpulkan bahwa game online berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. (3) Media sosial dan game online berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. Hal tersebut dibuktikan berdasarkan hasil uji F yang diperoleh nilai 0,000 < 0,05 sehingga H03 ditolak dan Ha3
Konsep Tauhidullah sebagai Substansi Pendidikan Islam
Authors: Rosadi Adi , Hambali Adang , Suhartini Andewi
Published: September 2024

Tujuan pembahasan artikel ini yaitu mengkaji tentang konsep tauhidullah sebagai substansi pendidikan islam. Pendekatan penelitian ini yaitu kualitatif dengan metode studi pustaka (library research). Teknik pengumpulan data dengan cara mencari sumber dan merkontruksi dari berbagai sumber seperti buku, jurnal, dan riset-riset yang sudah ada. Metode analisis menggunakan analisis konten. Artikel ini menyimpulkan pendidikan Islam mengajarkan tauhid sebagai inti pendidikan untuk membentuk taqwa siswa. Dengan pemahaman komprehensif tentang tauhid, siswa dapat memiliki karakter dan sikap yang baik. Pendidikan Islam mengintegrasikan konsep kesatuan untuk mengembangkan siswa yang memiliki kesadaran spiritual, kecerdasan intelektual, moralitas yang baik, dan keterampilan sosial yang seimbang. Ini meliputi penghargaan terhadap lingkungan, hubungan harmonis dengan sesama manusia, pengamalan ajaran agama, dan mencapai tujuan hidup yang abadi dengan Allah. Pendidikan Islam menawarkan pendekatan holistik yang terintegrasi untuk membentuk siswa yang tercerahkan, disiplin, bertanggung jawab, penuh kasih sayang, dan solidaritas.
Effect of Social Cognitive Skills Training (SCST) on Cognitive and Affective Theory of Mind in Adolescents
Authors:   Christ University, Bengaluru, Jacob Leema , Reddy Jayasankara ,   Christ University, Bengaluru
Published: September 2024

Social cognitive skills training (SCST) in a therapeutic setup can result in more positive outcomes when incorporated with psychotherapy, especially among adolescents with minor social-cognitive impairments, and it may result in multifarious benefits to mitigate their social-cognitive dysfunction. This research focuses on the effect of SCST on the cognitive and affective theory of mind for adolescents with low social cognition. Quasi-experimental research with a pre-test-post-test design was used. Edinburgh Social Cognition test (ESCoT) was used for pre-and post-testing one week before and post-SCST training. The significant findings reveal a positive impact of SCST on the affective theory of mind and cognitive theory of mind in the experimental group. No significant changes were found in the control group (waitlisted). The results help validate the SCST module to improve an adolescent’s cognitive and affective theory of mind in social cognition. Further implications are discussed.
Fenómenos lineales y no lineales en la transmisión por fibra óptica
Authors: Cecilia Karla , Eliécer Jorge , Leonardo Luis
Published: September 2024

En la fibra óptica se presentan fenómenos que afectan el rendimiento de los sistemas de comunicación. Comprender estos comportamientos facilita la selección del tipo de fibra requerido, la optimización de la capacidad de la fibra óptica elegida y la mitigación de los efectos adversos. Por estas razones, en este libro se proporciona el análisis matemático y conceptual de los fenómenos lineales y no lineales presentes en la transmisión de datos por fibra óptica. La obra usa un lenguaje sencillo, con ejemplos puntuales, y utiliza como apoyo una herramienta computacional libre para agilizar los cálculos matemáticos y los gráficos. Primero, se introduce al lector a los tipos de fibra óptica, los componentes de un sistema optoelectrónico, el espectro electromagnético donde operan, la ecuación no lineal de Schrödinger y la ecuación de Helmholtz; seguidamente, se presenta la aplicación de la óptica geométrica en la fibra; posteriormente, el texto se enfoca en los fenómenos de atenuación y dispersión en el marco de una operación lineal y luego considera la operación no lineal, el efecto Kerr, la automodulación de fase y la dispersión de tercer orden. Por último, se analiza la mezcla de cuarta onda en un sistema de tres canales. 
Tło starożytne 1 Kor 5,1
Authors: Wojciechowski Michał
Published: September 2024

W 1 Kor 5,1 Paweł nawiązał do skandalu we wspólnocie korynckiej, gdzie chrześcijanin żył ze swoją macochą. Greckie i rzymskie źródła faktycznie potępiały takie sytuacje, nawet zakładając, że były one sporadycznie. Za winne uznawano kobiety raczej niż mężczyzn. Tolerancja okazana przez wspólnotę koryncką mogłaby się tłumaczyć przypadkami, kiedy taki związek był usprawiedliwiany przez jakieś specjalne okoliczności. Znanym nam przykładem jest małżeństwo Antiocha I z jego macochą Stratoniką opisane przez Appiana w Historii rzymskiej XI,10,59–61 (por. Plutarch, Demetriusz 38; por. dawniej Sofokles, Trachinki 1221–1229).
Monoteletyzm w Bizancjum VII wieku: między terminologią a znaczeniem
Authors: Kashchuk Oleksandr
Published: September 2024

W Bizancjum VII w. rozpoczęła się długa i gorąca dyskusja na temat woli i energii w Chrystusie, która stała się głównym zagadnieniem teologicznym tego wieku. Wraz z trwającą debatą teologiczną problematyka ta ewoluowała. Niniejszy artykuł jest próbą przybliżenia specyfiki monoteletyzmu pod względem merytoryczno-terminologicznym i przedstawienia jego kluczowych twierdzeń. W artykule omawiany jest związek między poglądem o jedności osoby Chrystusa a przekonaniem o jedności Jego woli. Są również przedstawiane racje za utrzymywaniem przez monoteletów swoistej terminologii, a także wyjaśniana jest istota monoteletyzmu.
Shaping the Value of Respecting the Dignity of People with Disabilities in the Context of Education for Peace: Analysis and Implications
Authors: Szeler Katarzyna
Published: September 2024

Education for peace is one of the foundations of a well-functioning society and a prerequisite for ensuring the dignity of every individual. The inclusion of as many individuals as possible, among others, people with disabilities, to participate fully in society is carried out, among other things, in the field of and through education. In the article presented here, a secondary analysis of qualitative foundational data was carried out, addressing the issue of values underpinning education and upbringing as efforts to promote a culture of peace. The formation of positive social attitudes in children and adolescents, acceptance and respect for all people, regardless of their disabilities, can create a society based on the values of peace and dignity of each person.
Pathophysiological and Clinical Potential of Human Microbiome: Microbe-based Therapeutic Insights
Authors: Sanyal Somali , Nigam Kumud , Singh Sukriti , Lohani Puja , Dwivedi Manish
Published: September 2024

The human microbiota represents the community and diverse population of microbes
within the human body, which comprises approximately 100 trillion micro-organisms. They
exist in the human gastrointestinal tract and various other organs and are now considered virtual
body organs. It is mainly represented by bacteria but also includes viruses, fungi, and protozoa.
Although there is a heritable component to the gut microbiota, environmental factors related to
diet, drugs, and anthropometry determine the composition of the microbiota. Besides the gastrointestinal
tract, the human body also harbours microbial communities in the skin, oral and nasal
cavities, and reproductive tract. The current review demonstrates the role of gut microbiota and
its involvement in processing food, drugs, and immune responses. The discussion focuses on the
implications of human microbiota in developing several diseases, such as gastrointestinal infections,
metabolic disorders, malignancies, etc., through symbiotic relationships. The microbial
population may vary depending on the pathophysiological condition of an individual and thus
may be exploited as a therapeutic and clinical player. Further, we need a more thorough investigation
to establish the correlation between microbes and pathophysiology in humans and propose
them as potential therapeutic targets.
Phytosomes in Cancer Treatment: Harnessing Plant Extracts for Enhanced Efficacy
Authors: Sachdeva Shubham , Mittal Sanjiv , Kaur Harwinder , Singh Jitender
Published: September 2024

Cancer remains a formidable global health challenge, necessitating continuous exploration
of novel therapeutic strategies. Phytosomes, emerging as a promising drug delivery system,
offer a unique avenue for improving the efficacy of plant-derived compounds in cancer treatment.
This review delves into the current landscape of research surrounding phytosomes in cancer therapy,
elucidating their mechanisms of action, preclinical and clinical evidence, and future prospects.
By harnessing the encapsulation technology of phytosomes, plant extracts with known anticancer
properties are delivered with enhanced bioavailability and targeted efficacy. Preclinical studies demonstrate
the ability of phytosomes to modulate apoptotic pathways, inhibit angiogenesis, and exert
cytotoxic effects on cancer cells. Clinical trials further support the safety and efficacy of phytosome-
based therapies, with a focus on various cancer types such as breast, prostate, colorectal,
lung, and pancreatic cancer. The review also addresses challenges such as formulation optimization
and regulatory considerations. Looking ahead, phytosomes hold promise not only as standalone
therapeutics but also as components of combination therapies and personalized treatment
regimens. This review underscores the transformative potential of phytosomes in augmenting the
therapeutic arsenal against cancer, offering insights into future research directions and clinical applications.
Electrochemical Behavior of an Anti-cancer Drug Erlotinib at Screen-Printed Electrode and its Analytical Application
Authors: Manjulabhai Pooja Das , Warrier Arun , Raveendran Dr. Jeethu , Gangadharan Dr. Dhanya
Published: September 2024

Background:

Erlotinib (ERL) is a crucial tyrosine kinase inhibitor utilized for treating
non-small cell lung cancer (NSCLC) and pancreatic cancer. However, due to its significant adverse
effects, precise dosage monitoring is essential throughout treatments.

Methods:

This study developed a sensitive and specific screen-printed electrode (SPE) sensor to
detect erlotinib in human serum, urine, and pharmaceutical dosage forms. The sensor's linear response
range, limit of detection (LOD), and limit of quantification (LOQ) were determined. Additionally,
the sensor's selectivity was assessed by studying electro-oxidation in the presence of common
interfering molecules.

Results:

The developed sensor exhibited a linear response range of 2.0 μM to 34.0 μM, with a LOD
of 0.03 μM and a LOQ of 0.84 μM. Excellent recovery values were observed in human serum, urine,
and tablet dosage forms, demonstrating the sensor's applicability. The selectivity study confirmed the
sensor's ability to accurately quantify erlotinib in the presence of interfering substances.

Conclusion:

The research presents a novel and reliable technique for therapeutic drug monitoring of
erlotinib using a screen-printed electrode sensor. This method offers a quick, simple, and costeffective
approach for detecting ERL in actual samples, thereby facilitating improved dosage monitoring
in clinical settings.
Pengaruh Celebrity Endorser, Harga, Dan Event Marketing Terhadap Purchase Decision
Authors: Ishlah Benayya , Basuki Ananto
Published: September 2024

The large number of users of Erigo products in Indonesia indicates that Erigo can attract the Indonesian market. Erigo is one of the largest clothing companies in Indonesia, which has attracted many consumers in Indonesia. Even so, consumers have different opinions on consumer purchasing decisions, especially on the aspect of customer satisfaction. While the research conducted can be categorized as explanatory research by applying quantitative research that explains causal relationships between variables through hypothesis testing. This study used a sample of 131 respondents with a minimum age of 18 years, domiciled in South Tangerang and know Erigo. The data analysis tools used were descriptive statistical analysis and multiple linear regression analysis with the SPSS version 26 program. Based on the results of testing the four hypotheses, it can be concluded that; (1) the celebrity endorser variable (X1), which has a significant influence on the Purchase Decision, (2) the Price variable (X2), which has a significant influence on the Purchase Decision, (3) the Event Marketing variable (X3) which has a significant influence on the Purchase Decision, and (4) the influence of the independent variables simultaneously on the Purchase Decision variable is acceptable.
 
Abstrak
Banyaknya jumlah pengguna produk Erigo di Indonesia menandakan bahwa Erigo dapat menarik pasar Indonesia. Erigo merupakan salah satu perusahaan pakaian terbesar di Indonesia, yang telah diminati banyak konsumen di Indonesia. Meskipun begitu, konsumen memiliki pendapat yang berbeda terhadap keputusan pembelian konsumen, terutama pada aspek kepuasan dari konsumen. Sedangkan penelitian yang dilakukan dapat dikategorikan pada penelitian explanatory research dengan menerapkan penelitian kuantitatif yang menjelaskan hubungan sebab akibat antar variabel melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 131 responden dengan ketentuan berusia minimal 18 tahun, berdomisili di Tangerang Selatan dan mengetahui Erigo. Alat analisis data yang digunakan adalah analisis deskriptif statistik dan analisis regresi linear berganda dengan program SPSS versi 26. Berdasarkan hasil pengujian empat butir hipotesis, dapat disimpulkan bahwa; (1) variabel Celebrity endorser (X1), yang mempunyai pengaruh signifikan terhadap Purchase Decision, (2) variabel Harga (X2), yang mempunyai pengaruh signifikan terhadap Purchase Decision, (3) variabel Event Marketing (X3) yang mempunyai pengaruh signifikan terhadap Purchase Decision, dan (4) adanya pengaruh secara bersama-sama (simultan) variabel bebas terhadap variabel Purchase Decision dapat diterima.