bluuebunny/crossref_metadata_2025 huggingface dataset:
What to Teach in Small Animal Veterinary Orthopedics: A Survey of Practicing Veterinarians to Inform Curriculum Development
Authors: Duerr Felix , Lambrechts Nicolaas , Duncan Colleen , Gibbs Connor P. , West Andrew , Rishniw Mark , Elam Lindsay
Published: January 2023

Competency-based veterinary education focuses on the knowledge and clinical skills required to generate a productive and confident practitioner. Accurate identification of clinically relevant core competencies enables academic institutions to prioritize which new and foundational information to cover in the limited time available. The goal of this study was to aggregate the opinions of veterinary practitioners about small animal core competencies in veterinary orthopedics. An online 20-question survey was distributed with questions regarding respondent demographics, education, practice type, caseload, involvement in orthopedic procedures, access to referral hospitals, frequency of orthopedic condition presentation and procedure performance, and proposed percent allocation of various orthopedic curriculum topics. Responses were included from 721 respondents, largely first-opinion veterinarians (81%, n = 580/721). The majority (58%; n = 418/721) of respondents performed less than 10% of the orthopedic surgeries themselves and, 37% ( n = 266/721) reported never performing orthopedic surgery; of those performing surgeries, 78% ( n = 354/455) performed less than six orthopedic procedures monthly. The five most common orthopedic conditions seen included generalized osteoarthritis, patellar luxation, cranial cruciate ligament disease, hip dysplasia/arthritis, and muscle/tendon injuries. Median respondent scores for the percentage that a topic should compose in an ideal orthopedic curriculum were 20% each for “orthopedic exam” and for “non-surgical orthopedic knowledge,” 15% each for “non-surgical orthopedic skills,” “orthopedic imaging (radiographs),” and “surgical orthopedic knowledge,” 10% for “surgical orthopedic skills,” and 2% for “advanced orthopedic imaging.” Based on these results, a curriculum focusing on the most clinically relevant orthopedic conditions with an emphasis on diagnosis establishment and non-surgical treatments is proposed.
PRELIMINARY RESEARCH OF THE POSSIBILITY OF USING SOLID MINE WASTE AS FERTILIZER
Authors:   Donetsk National Technical University, Kostenko Viktor , Bohomaz Olha ,   Donetsk National Technical University, Hlushko Inna ,   Donetsk National Technical University
Published: January 2023

Purpose. Study of the possibility of using burned waste from slagheaps and bottom silty deposits of reservoirs as the main ingredients of organo-mineral fertilizer, due to determination of fertility indicators of soil treated with waste. Methodology. On the basis of laboratory studies of the potential fertility of the soil environment and studies of the dynamics of plant germination on experimental soils, the physical and chemical properties of the ingredients of the organo-mineral fertilizer have been determined. Results. As a result of the laboratory studies, it has been found that the addition of burned waste material from slagheaps and bottom silty deposits of reservoirs to the substrate enriched with the products of the processing of Californian earthworms does not reduce the fertility indicators of the substrate. The addition of such admixtures to soils with low and medium indicators of potential fertility will increase their productivity. Scientific novelty. A new composition of ecologically safe organic-mineral fertilizer based on burnt solid mine waste, bottom muddy sediments of reservoirs with the addition of chernozem treated with red California earthworms has been suggested. Practical significance. The use of burned waste mass from slagheaps and bottom silty deposits of reservoirs for the production of cheap composite organo-mineral fertilizers will reduce the anthropogenic load on the environment from mine wastes, increase the content of humus and improve the structure of agricultural soils.
TÜKETİCİ YALNIZLIĞININ ALIŞVERİŞ MOTİVASYONU ÜZERİNE ETKİSİ
Authors: KÖMÜRCÜOĞLU SOYTÜRK Fatma , FIRAT Aytekin
Published: January 2023

Dijitalleşme ile insanların hem yakınlaştığı hem de birbirinden uzaklaştığı bu dönemde yapılan araştırmalar insanların eskiye göre kendilerini yalnız hissettikleri yönünde olmuş ve bu durum akla şu soruyu getirmiştir. Yalnızlık durumunun tüketici alışveriş motivasyonu üzerine etkisi var mıdır? Bu sorudan yola çıkarak bu çalışmada yalnızlığın alışveriş motivasyonu üzerine etkisinin incelenmesi amaçlanmıştır. Bu doğrultuda nicel araştırma yöntemlerinden çevrimiçi anket tekniği ile yalnızlık ölçeği ve alışveriş motivasyonu ölçeği kullanılarak veriler toplanmıştır. Çalışmada 788 kişilik kullanılabilir örneklem elde edilmiştir. Verilerin analizinde ise IBM SPSS paket programı kullanılmıştır. Doğrulayıcı faktör analizi için ise IBM AMOS 26 paket programı kullanılmıştır. Önce ön testler için güvenilirlik ve faktör analizleri yapılmıştır. Demografik özelliklerin analizinde frekans analizi kullanılmıştır. Tüketici yalnızlığının tüketicinin alışveriş motivasyonu üzerindeki etkisini ölçerken basit doğrusal regresyon testlerinden yararlanılmıştır. Bu testin yapılabilmesi için ön koşul olan Kolerasyon analizi de yapılmıştır. Çalışmanın sonucunda yalnızlık ile alışveriş motivasyonunun sosyalleşme ve başkalarını mutlu etme boyutu arasında anlamlı ve negatif yönlü bir ilişki olduğu sonucuna ulaşılmıştır. İlişki testi sonucunda yapılan regresyon analizine göre ise model anlamlı bulunmuş ve yalnızlığın alışveriş motivasyonunun sosyalleşme ve başkalarını mutlu etme alt boyutunda etkisi olduğu sonucuna varılmıştır.
GİRİŞİMSEL YÖNELİM, ÖZÜMSEME KAPASİTESİ VE FİRMA PERFORMANSI ARASINDAKİ İLİŞKİ
Authors: İMAMOĞLU Salih Zeki , TÜRKCAN Hülya , KARAKUŞ Hacer
Published: January 2023

Pazardaki hızlı değişim ve artan bilgi, firmaların başarılı olmak için bu duruma ayak uydurmalarını gerektirmektedir. Hızlı değişim karşısında firmalar, pazar fırsatlarını tespit etmeli ve bunları en iyi şekilde değerlendirmelidir. Girişimciliğe önem verip, bu doğrultuda bir stratejik duruşa sahip olmak firmaların değişim ortamlarında öne çıkması açısından kilit bir faktördür. Diğer yandan artan bilgi karşısında, faydalı bilginin edinilip firma yararına kullanılması önem arz etmektedir. Dolayısıyla firmaların bilginin değerini fark edip, onu en iyi şekilde yönetmelerini sağlayan yetenekleri başarı için belirleyici bir diğer faktör olarak öne çıkmaktadır. Bu çalışmanın amacı, girişimsel yönelim, özümseme kapasitesi ve firma performansı arasındaki ilişkileri incelemektir. Bu kapsamda, Kocaeli’nde faaliyet gösteren firmalarda çalışan 198 orta ve üst düzey yöneticiden anket yöntemi kullanılarak veri toplanmıştır ve toplanan veriler yapısal eşitlik modeli ile test edilmiştir. Araştırma sonuçlarına göre, girişimsel yönelimin hem özümseme kapasitesi ile hem de firma performansı ile pozitif ilişkili olduğu tespit edilmiştir. Ayrıca özümseme kapasitesi ile firma performansının arasında pozitif bir ilişki olduğu sonucuna varılmıştır.
Verteporfin-loaded microparticles for radiosensitization of preclinical lung and breast metastatic spine cancer
Authors: Akinduro Oluwaseun O. , Suarez-Meade Paola , Roberts McKinley , Tzeng Stephany Y. , Sarabia-Estrada Rachel , Schiapparelli Paula , Norton Emily S. , Gokaslan Ziya L. , Anastasiadis Panos Z. , Guerrero-Cázares Hugo , Green Jordan J. , Quiñones-Hinojosa Alfredo
Published: January 2023

OBJECTIVE

The vertebral column is the most common site for skeletal metastasis, often leading to debilitating pain and weakness. Metastatic cancer has unique genetic drivers that potentiate tumorigenicity. There is an unmet need for novel targeted therapy in patients with spinal metastatic disease.

METHODS

The authors assessed the effect of verteporfin-induced yes-associated protein (YAP) inhibition on spine metastatic cell tumorigenicity and radiation sensitivity in vitro. Animal studies used a subcutaneous xenograft mouse model to assess the use of systemic intraperitoneal verteporfin (IP-VP) and intratumoral verteporfin microparticles (IT-VP) to inhibit the tumorigenicity of lung and breast spinal metastatic tumors from primary patient-derived tissue.

RESULTS

Verteporfin led to a dose-dependent decrease in migration, clonogenicity, and cell viability via inhibition of YAP and downstream effectors cyclin D1, CTGF, TOP2A, ANDRD1, MCL-1, FOSL2, KIF14, and KIF23. This was confirmed with knockdown of YAP. Verteporfin has an additive response when combined with radiation, and knockdown of YAP rendered cells more sensitive to radiation. The addition of verteporfin to YAP knockdown cells did not significantly alter migration, clonogenicity, or cell viability. IP-VP and IT-VP led to diminished tumor growth (p < 0.0001), especially when combined with radiation (p < 0.0001). Tissue analysis revealed diminished expression of YAP (p < 0.0001), MCL-1 (p < 0.0001), and Ki-67 (p < 0.0001) in tissue from verteporfin-treated tumors compared with vehicle-treated tumors.

CONCLUSIONS

This is the first study to demonstrate that verteporfin-mediated inhibition of YAP leads to diminished tumorigenicity in lung and breast spinal metastatic cancer cells. Targeting of YAP with verteporfin offers promising results that could be translated to human clinical trials.
Glucose-6-phosphate dehydrogenase and 8-iso-prostaglandin F2α as potential predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Authors: Wiśniewski Karol , Popęda Marta , Price Benjamin , Bieńkowski Michał , Fahlström Andreas , Drummond Katharine , Adamides Alexios A.
Published: January 2023

OBJECTIVE

Delayed cerebral ischemia (DCI) is a serious complication of aneurysmal subarachnoid hemorrhage (aSAH), which is responsible for significant death and disability. The dynamic balance between the production and elimination of reactive oxygen species (ROS) in patients with DCI is suspected be shifted to favor ROS formation. The authors assessed the relationship between F2-isoprostanes (F2-IsoPs), oxidative stress biomarkers, and glucose-6-phosphate dehydrogenase (G6PD), which are responsible for nicotinamide adenine dinucleotide phosphate (NADPH) production for glutathione system function, with post-aSAH DCI.

METHODS

The authors assessed 45 aSAH patients for F2-IsoP and G6PD concentration using commercial ELISA on days 2, 4, and 6 after aSAH. The authors examined the correlation between plasma F2-IsoP and G6PD concentrations and clinical factors with DCI occurrence and aSAH outcome.

RESULTS

Expectedly, the most important clinical predictors of DCI were Hunt and Hess grade and modified Fisher (mFisher) grade. Plasma F2-IsoP and G6PD concentrations were greater in aSAH patients than the control group (p < 0.01). F2-IsoP concentrations were greater and G6PD concentrations were lower in patients with DCI than those without (p < 0.01). Plasma F2-IsoP and G6PD concentrations on day 2 were correlated with DCI occurrence (p < 0.01). Plasma F2-IsoP concentrations on days 2 and 6 were correlated with outcome at 1 and 12 months (p < 0.01).

CONCLUSIONS

Decreased G6PD indirectly informs the reduced antioxidant response, especially for the glutathione system. G6PD concentration was lower in patients with DCI than those without, which may explain the increased F2-IsoP concentrations. mFisher grade, plasma F2-IsoP concentration, and G6PD concentration on day 2 after aSAH, in combination, may serve as predictors of DCI. Further research is necessary to investigate the therapeutic utility of F2-IsoPs and antioxidants in clinical practice.
Preoperative elevated eosinophils in peripheral blood for prediction of postoperative recurrence of chronic subdural hematoma
Authors: Matsubara Maoki , Yagi Kenji , Minami Yukari , Kanda Eiichiro , Sunada Yoshihiro , Tao Yoshifumi , Takai Hiroki , Shikata Eiji , Hirai Satoshi , Matsubara Shunji , Uno Masaaki
Published: January 2023

OBJECTIVE

Chronic subdural hematoma (CSDH) is a common neurological disease with a significant postoperative recurrence rate. There are numerous reported studies of the development of CSDH. In recent years, fibrinolysis, angiogenesis, and inflammation have all been identified as relevant factors in the development of CSDH. While several authors have reported risk factors associated with CSDH recurrence, differential blood count of leukocytes has not yet been discussed. Therefore, in this study the authors aimed to retrospectively investigate the association between differential blood leukocyte count and the rate of CSDH recurrence.

METHODS

The authors retrospectively reviewed 476 patients with 529 CSDHs who underwent surgery at a single institution between January 2011 and December 2021. After exclusion of patients who had not undergone a differential blood test of leukocytes preoperatively, CSDHs in 517 cerebral hemispheres of 466 patients were included in the study. Peripheral blood eosinophil counts ≥ 100/µL were considered eosinophil rich.

RESULTS

CSDHs in 494 cerebral hemispheres of 445 patients were followed up postoperatively for at least 3 months or until resolution indicated by CSDH disappearance. Postoperative recurrence of CSDH was observed in 46 cerebral hemispheres (9.3%). Among the preoperative differential blood counts of all leukocytes, eosinophils alone were significantly associated with CSDH recurrence (median [IQR] 76/µL [30–155/µL] vs 119/µL [39–217/µL]; p = 0.03). Multivariable regression analysis showed thrombocytopenia (adjusted OR [aOR] 5.23, 95% CI 1.85–14.79; p = 0.002), use of anticoagulant drugs (aOR 2.51, 95% CI 1.17–5.38; p = 0.02), hematoma volume (10 mL per increase) (aOR 1.08, 95% CI 1.00–1.16; p = 0.04), and eosinophil-rich peripheral blood (aOR 2.22, 95% CI 1.17–4.23; p = 0.02) were all independent predictors for CSDH recurrence.

CONCLUSIONS

This study showed that preoperative peripheral blood eosinophil count was an independent risk factor for CSDH recurrence. Therefore, patients with CSDH who have elevated eosinophils preoperatively in peripheral blood require careful follow-up.
The association between Disease Activity Score and rheumatoid arthritis–associated cervical deformity: radiological evaluation of the BeSt trial
Authors: Lebouille-Veldman Anna B. , Spenkelink Dylan , Allaart Cornelia F. , Vleggeert-Lankamp Carmen L. A.
Published: January 2023

OBJECTIVE

The authors’ objective was to evaluate the association of the Disease Activity Score (DAS) with cervical spine deformity in rheumatoid arthritis (RA) patients during 10-year optimal treatment of systemic disease.

METHODS

The authors evaluated radiological and 10-year follow-up (FU) data of the BeSt (BehandelStrategien) trial. In 272 RA patients, atlantoaxial subluxation (AAS), presence of vertical translocation (VT), and subaxial subluxation (SAS) were evaluated. The associations of these deformities with DAS, self-assessed health (determined with the Health Assessment Questionnaire [HAQ]), and erosions of the hands and feet (Sharp–Van der Heijde score) were studied.

RESULTS

After 10 years of FU, AAS (> 2 mm neutral position) was observed in 62 patients (23%), AAS (≥ 3 mm in flexion) in 24%, AAS (≥ 5 mm in flexion) in 7%, VT did not occur, and SAS was present in 60 patients (22%). In total, 135 patients (50%) were in remission (DAS < 1.6) at 10 years of FU. No association could be established between AAS and DAS. Patients with cervical spine deformity (AAS > 2 mm and/or SAS) at 10 years had a higher HAQ score at 10 years than patients without cervical spine deformity (HAQ scores of 0.65 and 0.51, respectively, p = 0.04; 95% CI –0.29 to 0.00).

CONCLUSIONS

Even though 50% of patients were in remission after 10 years and the BeSt trial was designed to optimize treatment, 40% of patients developed at least mild RA-associated cervical spine deformity and 7% developed significant AAS. This indicates that even in this era of disease-modifying antirheumatic drugs and biologicals, cervical deformity is prevalent among patients with RA and should not be neglected in patient treatment plans and information.
Correlation Properties Investigation of Signaling Sequences to Optimize the 5G NR Random Access Channel Characteristics
Authors: Babanov I.
Published: January 2023

The article describes a random access channel optimization technique based on the choice of roots for constructing random access preambles, the detection probability of which is higher than the roots selected in the classical way according. The results of simulation modeling are presented for the entire set of preambles 839 samples long. It is shown that with an increase in the number of simultaneously transmitted preambles, the spread of possible values of the correlation coefficient increases, which directly affects the success of detection. The conclusion is made about the possibility of optimizing the characteristics of the random access channel, both in terms of the configuration of the random access channel resources and based on the rational choice of the roots of the signal-forming preambles.
Deep Learning Approaches for Traffic Prediction Forecasting in Multi-Level Cloud Architecture for Autonomous Vehicle Services
Authors: Alsweity M.
Published: January 2023

Autonomous vehicle (AV) is one of the most new use cases and a technology for fifth-generation (5G) and next-generation mobile networks in numerous applications., the use of AVs has exponentially worldwide due to the rapidly growing awareness and use of artificial intelligence (AI) methods in various fields. Predicting data flows is essential for AVs to improve data transmission and decrease delays through more efficient use of appropriate capabilities, monitoring, management, and control of the traffic system. This paper proposes a deep learning approach (DL) with the bidirectional long-short-term memory model (BI-LSTM) for predicting the traffic rates of AVs with multi-cloud services. In terms of prediction accuracy, a comparison is conducted between the BI-LSTM and the unidirectional LSTM based on the number of batch sizes used. The prediction accuracy is computed using the root mean square error (RMSE), mean absolute percentage error (MAPE), coefficient of determination (R2), and processing time. The results show that the prediction accuracy with BI-LSTM outperforms the LSTM model. Besides, the prediction accuracy using 8 batch sizes outperforms the competitors and offers outstanding performance.
STOKES SYSTEM WITH VARIABLE EXPONENTS OF NONLINEARITY
Authors: Buhrii O. , Khoma M.
Published: January 2023

Some nonlinear Stokes system is considered. The initial-boundary value problem for the system is investigated and the existence and uniqueness of the weak solution for the problem is proved.
A MULTIPOINT IN-TIME PROBLEM FOR THE 2b-PARABOLIC EQUATION WITH DEGENERATION
Authors: Pukalskyy I. , Yashan B.
Published: January 2023

In recent decades, special attention has been paid to problems with nonlocal conditions for partial differential equations. Such interest in such problems is due to both the needs of the general therapy of boundary value problems and their rich practical application (the process of diffusion, oscillations, salt and moisture transport in soils, plasma physics, mathematical
biology, etc.).
A multipoint in-time problem for a nonuniformly 2b-parabolic equation with degeneracy is studied. The coefficients of the parabolic equation of order 2b allow for power singularities of arbitrary order both in the time and spatial variables at some set of points. Solutions of auxiliary problems with smooth coefficients are studied to solve the given problem. Using a priori estimates, inequalities are established for solving problems and their derivatives in special Hölder spaces. Using the theorems of Archel and Riess, a convergent sequence is distinguished from a compact sequence of solutions of auxiliary problems, the limiting value of which will be the solution of the given problem. Estimates of the solution of the multipoint time problem for the 2b-parabolic equation are established in Hölder spaces with power-law weights. The order of the power weight is determined by the order of degeneracy of the coefficients of the groups of higher terms and the power features of the coefficients of the lower terms of the parabolic equation. With certain restrictions on the right-hand side of the equation, an integral image of the solution to the given problem is obtained.
The Scientist’s Talent Multiplied by Work: Reproduction of the Image of Prof. Natalia Mazepa on the Pages of a Unique Edition
Authors: Nikoriak Nataliia
Published: January 2023

Review on the book: Skvira, N. (ed.) (2021). Zhyvotvorne svitlo slova: zbirnyk naukovykh studii pamiati doktorky filolohichnykh nauk Nataliï Rostyslavivny Mazepy [The Life-Giving Light of the Word: A Collection of Scientific Studies in Memory of Natalia Rostyslavivna Mazepa, Doctor of Philological Sciences]. Kyiv : Vydavnychyi dim Dmytra Buraho, 2021, 346 p. (in Ukrainian)
Determinants of Intentions towards Sustainable Consumption among University Students in Nigeria: The Role of Sustainability-oriented Marketing Education and Morality
Authors: Godswill Agu Agu , G. Etuk Samuel , Ebeke Egele Aja , C. Ibekwe Francisca , Nnamocha Obiageli Angela
Published: January 2023

Education and moral values influence human behaviour, including intention to engage in actions that are beneficial to the society. Increasing research effort has recently focused on sustainable human behaviour, but research that explores the role of sustainability-oriented marketing education (SME) and morality in stimulating sustainable actions, such as sustainable consumption, seems to be missing in the literature. The purpose of this research is to examine how SME and morality influence sustainable consumption intentions among university students, basing on an extended theory of planned behaviour. An online quantitative survey of Management Science students in Nigerian Universities was conducted. Data analysis was based on the SmartPLS structural equation modeling. Findings suggest that SME relates positively with all the constructs, while morality influences sustainable consumption intention and fully mediates the relationship between SME and sustainable consumption intention. However, attitude, subjective norms and perceived behavioural control emerged as non-significant determinants of sustainable consumption intention.
Efektivitas Pendidikan Kesehatan Dalam Pelaksanaan Program Gesit Mandiri Terhadap Kepatuhan Minum Obat Pada Pasien Hipertensi Di Wilayah Kerja Puskesmas Takisung
Authors: Nurhidayani Nurhidayani , Er Unja Ermeisi , Andi Chrimilasari Lucia
Published: January 2023

Angka prevalensi hipertensi di Kalimantan Selatan yang meningkat dari tahun sebelumnya memberikan kekhawatiran tersendiri. Tercatat penderita hipertensi di wilayah kerja Puskesmas Takisung pada tahun 2019 dengan kasus baru sebanyak 2585 orang (79,4 %). Kurangnya pengetahuan dapat mempengaruhi pasien hipertensi untuk mengatasi kekambuhan dan pencegahan komplikasi. Mengetahui efektifitas pendidikan kesehatan dalam Pelaksanaan program Gesit Mandiri terhadap kepatuhan minum obat pasien hipertensi di Wilayah kerja Puskesmas Takisung. Penelitian ini menggunakan Desain Quasy Experimental without control group. Sampel sebanyak 218 orang dipilih secara purposive sampling. Pengambilan sampel di lakukan sebelum dan sesudah intervensi. Terjadi peningkatan pengetahuan sesudah intervensi dengan kategori baik sebanyak 67% dan pada kategori kepatuhan sesudah intervensi dengan kategori patuh sebanyak 30 %. terdapat perbedaan yang signifikan antara pengetahuan sebelum dan sesudah intervensi. Ada pengaruh Pendidikan kesehatan dengan kepatuhan minum obat penderita hipertensi
Detection of Chronic Obstructive Pulmonary Disease among Smokers Aged ≥40 years Attending Primary Health Care Centers in Baghdad-AL-Karkh and AL-Resafa
Authors: Abd Ala Isra A. , Mousa Nada Abdul Wahhab , Al-Lami Faris
Published: January 2023

Background: Chronic obstructive pulmonary disease causes permanent morbidity, premature mortality and great burden to the healthcare system. Smoking is it's most common risk factor and Spirometry is for diagnosing COPD and monitoring its progression.
Objectives: Early detection of chronic obstructive pulmonary disease in symptomatic smokers’ ≥ 40years by spirometry.
Methods: A cross sectional study on all symptomatic smokers aged ≥ 40 years attending ten PHCCs in Baghdad Alkarkh and Alrisafa. Those whose FEV1/FVC was <70% on spirometry; after giving bronchodilator, were considered COPD +ve.
Results:  Overall, airway obstruction was seen in 206(46.8%). It is significantly associated with increase age (50-y), more in male and increase with increase duration and amount of smoking
Conclusions: COPD was prevalent among men and women. Early diagnosis of COPD is good for both patient and community. Routine spirometry is an easy way for screening and identifying asymptomatic patients. Before adoption of spirometry Cost-effectiveness is needed.
Association between Aggregatibacter actinomy-cetemcomitans bacterial load and NLRP3 inflam-masome activation in periodontitis patients with Diabetes
Authors: Al-obaidi Mohammed
Published: January 2023

Abstract: Background: Aggregatibacter actinomycetemcomitans is one of the most common periodontal pathogen that has a direct effect on periodontium. Diabetes and periodontitis considered as chronic diseases with a bidirectional relationship between them. Evidence has shown that the Node Like Receptor Pyrine-3  inflammasome, is crucial for both illnesses. Aim of study: This investigation was conducted to observe the association between bacterial load of A. actinomyctecomtans and serum level of NLRP3 inflammasome in periodontitis patient with and without type 2 DM and control group. Materials and Methods: This case-control study included 85 participants, whose ages ranged from (23-55) years. Split into three groups; the control group, which had a clinically and systemically healthy periodontium, and the two groups with periodontitis, one of which also had type 2 DM. Samples of the four most profound periodontal pockets were sampled for subgingival plaque, and from the gingival sulcus in the control group. The real-time (PCR) was utilized in this experiment. to quantify A. actinomyctecomtans DNA was isolated from samples of dental plaque. All subjects' serum was collected, and the concentration of NLRP3 was measured using an ELISA technique. Results: The results showed that the bacterial count was higher in two groups of patient than the control group, but there were no-significant differences. On the other hand, there was a significant correlation between the bacterial count and periodontal parameters in periodontitis with type 2 DM group, while in periodontitis group there was positive correlation with clinical attachment loss and bleeding on probing. A significant positive correlation also noticed between NLRP3 inflammasome and periodontal parameters in periodontitis patient with type2 DM. Regarding the group of periodontitis patients without systemic disease there was no significance correlation between inflammasome and clinical parameters. Finally, there is a non-significant correlation of A. actinomyctecomtans with inflammasome. Conclusions: A. actinomyctecomtans detection rate was strongly higher in patient groups compared to healthy subjects but statically non-significant. Moreover, the lack of correlation between A. actinomyctecomtans and the NLRP3 inflammasome indicates that NLRP3 activation is associated   with inflammatory processes that are induced by a number of external factors, other than bacteria.
Optimal control of a model for brain lactate kinetics
Authors: Raad Hussein , Cherfils Laurence , Allery Cyrille , Guillevin Rémy
Published: January 2023

The aim of this paper is to first study a Cahn-Hilliard model for brain lactate kinetics with a control function. This control allows for optimal treatment administered to ill patients suffering from glioma, in order to reduce their brain lactate concentrations, and thereby to slow down the tumor growth. We establish the well-posedness of the problem and the continuity of the control-to-state mapping, the existence of a minimizer of the objective functional, and its Fréchet differentiability in suitable Banach spaces with respect to the control and with respect to time. Moreover, we derive the first-order necessary conditions that an optimal control has to satisfy. In the second part of the paper, we illustrate our theoretical results with numerical simulations using MRI data from the University Hospital of Poitiers.
Vitamin D during treatment for breast cancer – the perspective of active self-help group leaders
Authors: Muecke Ralph , Dubois Clara , Micke Oliver , Keinki Christian , Huebner Jutta
Published: January 2023

BACKGROUND: In breast cancer patients, there is an elevated risk of developing osteoporosis during treatment which should be addressed by optimizing 25(OH) levels. OBJECTIVE: The aim was to assess the prescription, information and physician-patient communication on vitamin D and bone density in Germany. METHODS: We developed a standardized questionnaire concerning bone density measurement, vitamin D (blood level testing, prescription), information and communication regarding vitamin D. The questionnaire was distributed at the annual meeting of all group leaders of the Women’s Cancer Support Association to all participants. RESULTS: Overall, 224 participants completed the questionnaire; 77.7% reported having had at least one bone density measurement test. The number was 84.4% in patients treated with aromatase inhibitor and 43.7% reported that their bone density was too low. In total, 51.3% patients reported at least one vitamin D blood test and 45.1% reported that vitamin D had been primarily addressed by a physician. As many as 74.1% of those reporting a test result had a deficiency; 91.6% of those with a low level got a prescription and 28.4% took vitamin D autonomously. CONCLUSIONS: The awareness on risk of osteoporosis, prevention, early diagnosis and treatment are insufficiently addressed in a patient group with high risk of osteoporosis. More attention should be paid to the phenomenon of vitamin D deficiency or insufficiency in routine care.
Down-regulation of SLC16A-AS1 and LINC00900 lncRNAs in Iranian patients with breast cancer
Authors: Dorostgoo Zeinab , Fattahi Asieh Sadat , Moosavi Saide Samare , Ghafouri-Fard Soudeh , Oskooei Vahid Kholghi
Published: January 2023

Long non-coding RNAs (lncRNAs) influence pathetiology of breast cancer. Besides, VDR and ESR1 signaling pathways are two important pathways in this malignancy. In the present mixed bioinformatics and expression assay study, we have identified lncRNAs that are co-expressed with VDR and ESR1 in breast cancer tissues and analyzed their expression in 42 paired breast cancer and non-cancerous specimens. Expression of SLC16A-AS1 was significantly lower in breast cancer tissues compared with paired non-cancerous samples (expression ratio = 0.27, P value < 0.001). Similarly, LINC00900 was down-regulated in cancer tissues compared with non-cancerous ones (expression ratio = 0.26, P value = 0.01). There were no significant differences in the expressions of VDR and AATBC between these two sets of samples. Expression levels of VDR and AATBC were associated with histological grade (P values = 0.02 and 0.03, respectively). Moreover, expression of VDR was associated with tumor size (P value = 0.02). Finally, expression levels of SLC16A-AS1 were associated with first pregnancy age (P value = 0.006). In brief, the results of current study further support involvement of VDR and ESR1-associated lncRNAs in breast cancer.
A rare presentation of tuberculous adenitis mimicking metastatic breast lymphadenopathy
Authors: Ferre Romuald , Ghorab Zeina , Alikhassi Afsaneh , Curpen Belinda
Published: January 2023

Tuberculosis (TB) remains in 2022 a significant public health issue as it remains endemic in some areas of the globe, with a high prevalence in underdeveloped countries (Pujani, Khan, Hassan, Jetley, Raina, Breast Dis., 35(3): 195–198, 2015. doi:10.3233/BD-150405. PMID: 26406543). Pulmonary TB is the most common form, but TB can also have extrapulmonary manifestations like tubercular lymphadenopathy. Tuberculous lymphadenitis is the most extrapulmonary tuberculosis. It used to be called scrofula in the past coming from the Latin meaning breeding sow (Kokosali, Lloyd, Dent Update, 33(5): 306–308, 311, 2006. doi:10.12968/denu.2006.33.5.306. PMID: 16841612; Oberhelman, Watchmaker, Phillips, JAMA Dermatol, 155(5): 610, 2019. doi:10.1001/jamadermatol.2018.5651. PMID: 30942835). It is a common cause of peripheral lymphadenitis, seen mostly in the developing countries, but also reemerging among intravenous drugs users and immunocompromised population. Cervical nodes are the most commonly detected nodes in tuberculous lymphadenitis, accounting for 63% of the cases, followed by mediastinal (27%) and axillary nodes (8%) (Ahuja, Ying, Evans, King, Metreweli, Clin Radiol, 50(6): 391–395, 1995. doi:10.1016/s0009-9260(05)83136-8. PMID: 7789023). Tuberculous lymphadenitis affects predominantly the young population and children. There is also a slight female predilection. As to our knowledge, there have not been any reported cases as post-menopausal axillary tuberculous lymphadenitis, and it is the focus of this article.
Proteome profiling of ductal carcinoma in situ
Authors: Mosavi Zeinb , Bashi Zadeh Fakhar Haniyeh , Rezaei-Tavirani Mostafa , Akbari Mohamd Esmaeel , Rostami Forouzan
Published: January 2023

BACKGROUND AND AIM: DCIS is the most common type of non-invasive breast cancer, accounting for about 15 to 30%. Proteome profile is used to detect biomarkers in the tissues of breast cancer patients by mass spectrometry. This study aimed to obtain the expression profile of DCIS proteome, and the expression profile of invasive biomarkers, and finally to introduce a dedicated biomarker panel to facilitate the prognosis and early detection for in situ breast cancer patients. METHODS AND MATERIALS: In this study, 10 patients with breast cancer (DCIS) were studied. Benign (marginal) and cancerous tissue samples were obtained from patients for proteomics experiments. Initially, all tissue proteins were extracted using standard methods, and the proteins were separated using two-dimensional electrophoresis. Then, the expression amount of the extracted proteins was determined by ITRAQ. The data were analysed by R software, and gene ontology was utilised for describing the protein in detail. RESULTS: 30 spots on gel electrophoresis were found in the tumor tissue group (sample), and 15 spots in the margin group (control) with P < 0.05. Healthy and cancerous tissue gels showed that 5 spots had different expression. VWF, MMP9, ITGAM, MPO and PLG protein spots were identified using the site www.ebi.ac.uk/IPI. Finally, protein biomarkers for breast tumor tissue with margin were introduced with the names of P04406, P49915, P05323, P06733, and P02768. DISCUSSION: There are 5 critical proteins in inducing cancer pathways especially complement and coagulation cascades. The hall markers of a healthy cell to be cancerous are proliferation, invasion, angiogenesis, and changes in the immune system. Hence, regulation of protein plays a key role in developing recurrence to breast cancer in margins.
Prognostic value of androgen receptor expression in different molecular types of breast cancer in women
Authors: Elbalka Saleh S. , Metwally Islam H. , Hassan Amany , Eladl Ahmed E. , Shoman Ahmed M. , Jawad Mohamed , Shahda Eman , Abdelkhalek Mohamed
Published: January 2023

BACKGROUND: Breast cancer is a common women's disease. Usually, oestrogen is blamed in the aetiology and correlated with the prognosis; however, androgens are recently raising concern about its role in the breast cancer treatment and prognosis. METHODS: In this study we retrieved archival paraffin blocks of breast cancer patients and stained it for androgen. Thereafter, we compared clinico-epidemiologic parameters, histopathology, neoadjuvant response and recurrence rate and pattern among patients with and without androgen receptor (AR) expression. RESULTS: In total, 119 patients fulfilled enrolment criteria; AR expression were present in 77.3% of the patients. AR expression was associated with less grade III (6.8% versus 36.4%), and less triple negative (6.2% versus 25%), but similar overall recurrence rate (25% versus 22.2%). However, distant recurrence was significantly higher in androgen positive patients (91.3% versus 33.3% of all recurrences). CONCLUSION: Androgen expression appears to be common among breast cancer, but with no clear implication in tumour aggressiveness or effect on the rate of recurrence. However, being commonly associated with distant spread may have an impact on survival of the patients.
Correlation analysis of HIF-1α and Ca15-3 in response to neoadjuvant chemotherapy in locally advanced breast cancer: A cohort study in Indonesia
Authors: Manginstar Christian , Oley Mendy Hatibie , Oley Maximillian Christian , Merung Marselus , Langi Fima Lanra Fredrik G. , Kepel Billy Johnson , Rusli Lie Venny , Islam Andi Asadul , Faruk Muhammad
Published: January 2023

BACKGROUND: Breast cancer (BC) is the most common cancer among women worldwide and a leading cause of death in Indonesia. The primary treatment of locally advanced BC is neoadjuvant chemotherapy (NAC). The rapid proliferation of tumor cells in a neoplastic microenvironment is largely due to hypoxia, which also encourages the development of chemoresistant BC. The master regulator of the hypoxia response is hypoxia-inducible factor-1α (HIF-1α). The response evaluation criteria in solid tumors (RECIST) is an objective response metric that demonstrates the efficacy of a NAC based mostly on the size of the tumor. Ca15-3 is the protein product of the MUC1 gene and is the most widely used serum marker in BC. The purpose of this study is to investigate the relationship between HIF-1α and RECIST and between Ca15-3 and RECIST and to assess the relationship among all of them in BC. METHODS: This observational study used the prospective cohort method included 11 patients with histopathologically confirmed BC, specifically invasive ductal carcinoma. We evaluated the changes in HIF-1α and Ca15-3 serum levels using ELISA and measured tumor lesions with RECIST. The procedure was carried out twice. Serum levels were measured at baseline, and after receiving two cycles of NAC (5 weeks). RESULTS: Among the 11 patients included in this study, HIF-1α, Ca15-3, and RECIST decreased significantly after NAC. The changes in RECIST correlated with Ca15-3: each unit decrease in RECIST score was associated with a 0.3-unit decrease in Ca15-3 levels (p = 0.019). CONCLUSIONS: There was a decrease in HIF-1α, followed by a decrease in Ca15-3 and RECIST in response to chemotherapy. There was a statistically significant correlation between Ca15-3 and response to chemotherapy. This study evidences the relationship between factors that shape the local tumor microenvironment.
Developmentally Appropriate Prevention of Behavioral and Emotional Problems, Social-Emotional Learning, and Developmentally Appropriate Practice for Early Childhood Education and Care – The Papilio Approach from 0 to 9
Authors: Scheithauer Herbert , Scheer Heidi
Published: January 2023

This thematic section editorial gives an overview of the three related articles introducing the programs Papilio-3to6, Papilio-U3, and Papilio-6to9. The essential, connecting elements are presented (developmentally appropriate prevention, social-emotional learning [SEL], and developmentally appropriate practice) and the relation between the three programs is explained in the context of an overarching educational approach from 0 to 9 to early childhood education and care (ECEC).
Neuroprotective Mechanisms of Amylin Receptor Activation, Not Antagonism, in the APP/PS1 Mouse Model of Alzheimer’s Disease
Authors: Corrigan Rachel R. , Labrador Luis , Grizzanti John , Mey Megan , Piontkivska Helen , Casadesús Gemma
Published: January 2023

Background: Amylin, a pancreatic amyloid peptide involved in energy homeostasis, is increasingly studied in the context of Alzheimer’s disease (AD) etiology. To date, conflicting pathogenic and neuroprotective roles for this peptide and its analogs for AD pathogenesis have been described. Objective: Whether the benefits of amylin are associated with peripheral improvement of metabolic tone/function or directly through the activation of central amylin receptors is also unknown and downstream signaling mechanisms of amylin receptors are major objectives of this study. Methods: To address these questions more directly we delivered the amylin analog pramlintide systemically (IP), at previously identified therapeutic doses, while centrally (ICV) inhibiting the receptor using an amylin receptor antagonist (AC187), at doses known to impact CNS function. Results: Here we show that pramlintide improved cognitive function independently of CNS receptor activation and provide transcriptomic data that highlights potential mechanisms. Furthermore, we show than inhibition of the amylin receptor increased amyloid-beta pathology in female APP/PS1 mice, an effect than was mitigated by peripheral delivery of pramlintide. Through transcriptomic analysis of pramlintide therapy in AD-modeled mice we found sexual dimorphic modulation of neuroprotective mechanisms: oxidative stress protection in females and membrane stability and reduced neuronal excitability markers in males. Conclusion: These data suggest an uncoupling of functional and pathology-related events and highlighting a more complex receptor system and pharmacological relationship that must be carefully studied to clarify the role of amylin in CNS function and AD.
EEG Entropy in REM Sleep as a Physiologic Biomarker in Early Clinical Stages of Alzheimer’s Disease
Authors: Azami Hamed , Moguilner Sebastian , Penagos Hector , Sarkis Rani A. , Arnold Steven E. , Gomperts Stephen N. , Lam Alice D.
Published: January 2023

Background: Alzheimer’s disease (AD) is associated with EEG changes across the sleep-wake cycle. As the brain is a non-linear system, non-linear EEG features across behavioral states may provide an informative physiologic biomarker of AD. Multiscale fluctuation dispersion entropy (MFDE) provides a sensitive non-linear measure of EEG information content across a range of biologically relevant time-scales. Objective: To evaluate MFDE in awake and sleep EEGs as a potential biomarker for AD. Methods: We analyzed overnight scalp EEGs from 35 cognitively normal healthy controls, 23 participants with mild cognitive impairment (MCI), and 19 participants with mild dementia due to AD. We examined measures of entropy in wake and sleep states, including a slow-to-fast-activity ratio of entropy (SFAR-entropy). We compared SFAR-entropy to linear EEG measures including a slow-to-fast-activity ratio of power spectral density (SFAR-PSD) and relative alpha power, as well as to cognitive function. Results: SFAR-entropy differentiated dementia from MCI and controls. This effect was greatest in REM sleep, a state associated with high cholinergic activity. Differentiation was evident in the whole brain EEG and was most prominent in temporal and occipital regions. Five minutes of REM sleep was sufficient to distinguish dementia from MCI and controls. Higher SFAR-entropy during REM sleep was associated with worse performance on the Montreal Cognitive Assessment. Classifiers based on REM sleep SFAR-entropy distinguished dementia from MCI and controls with high accuracy, and outperformed classifiers based on SFAR-PSD and relative alpha power. Conclusion: SFAR-entropy measured in REM sleep robustly discriminates dementia in AD from MCI and healthy controls.
Data privacy in the Internet of Things based on anonymization: A review
Authors: Neves Flávio , Souza Rafael , Sousa Juliana , Bonfim Michel , Garcia Vinicius
Published: January 2023

The Internet of Things (IoT) has shown rapid growth in recent years. However, it presents challenges related to the lack of standardization of communication produced by different types of devices. Another problem area is the security and privacy of data generated by IoT devices. Thus, with the focus on grouping, analyzing, and classifying existing data security and privacy methods in IoT, based on data anonymization, we have conducted a Systematic Literature Review (SLR). We have therefore reviewed the history of works developing solutions for security and privacy in the IoT, particularly data anonymization and the leading technologies used by researchers in their work. We also discussed the challenges and future directions for research. The objective of the work is to give order to the main approaches that promise to provide or facilitate data privacy using anonymization in the IoT area. The study’s results can help us understand the best anonymization techniques to provide data security and privacy in IoT environments. In addition, the findings can also help us understand the limitations of existing approaches and identify areas for improvement. The results found in most of the studies analyzed indicate a lack of consensus in the following areas: (i) with regard to a solution with a standardized methodology to be applied in all scenarios that encompass IoT; (ii) the use of different techniques to anonymize the data; and (iii), the resolution of privacy issues. On the other hand, results made available by the k-anonymity technique proved efficient in combination with other techniques. In this context, data privacy presents one of the main challenges for broadening secure domains in applying privacy with anonymity.
Multivariate time-series anomaly detection via temporal convolutional and graph attention networks
Authors: He Qiang , Wang Guanqun , Wang Hengyou , Chen Linlin
Published: January 2023

Multivariate time series anomaly detection has been investigated extensively in recent years. Capturing long-term time series information is one of the challenges in this field. We propose a novel multivariate time series anomaly detection framework MTAD-TCGA comprising several modules that efficiently and accurately capture dependencies in long-term multivariate time series. The proposed model contains a temporal convolutional module and uses two parallel graph attention layers to learn the complex dependencies of time series in both the temporal and feature dimensions. A Gated Recurrent Unit layer, based on an improved attention mechanism, and an auto-regressive model is used for prediction, and the prediction model and reconstruction model are jointly optimized. Finally, the threshold is selected by extreme value theory, and then anomalies are identified. The experimental results on three public datasets show our framework is superior to other state-of-the-art models, achieving F1 scores uniformly at levels above 0.9, verifying the effectiveness and feasibility of the MTAD-TCGA method.
An efficient method for ideological and political education quality evaluation of colleges and universities with 2-tuple linguistic neutrosophic sets
Authors: Liu Jiacheng , Chau Gavin , Su Pianpain
Published: January 2023

Improving college students’ satisfaction with the teaching quality of ideological and political theory courses in colleges and universities is the need to promote college students to consciously fulfill their ideological and political quality, and it is also the need to further form a strong driving force for the teaching reform of ideological and political theory courses in colleges and universities. The requirements of teaching level are also the requirements to further enhance the competitiveness of colleges and universities. The ideological and political education quality (IPEQ) evaluation of college students is looked as multiple attribute group decision-making (MAGDM) problem. In this paper, the 2-tuple linguistic neutrosophic TOPSIS (2TLN-TOPSIS) model is built based on the traditional TOPSIS and 2-tuple linguistic neutrosophic sets (2TLNSs). Firstly, the 2TLNSs is introduced. Then, combine the TOPSIS model with 2TLNSs, the 2TLN-TOPSIS model is established for MAGDM. Finally, a numerical example for IPEQ evaluation of College students have been given and some comparisons are also conducted to further illustrate advantages of the 2TLN-TOPSIS method.