bluuebunny/crossref_metadata_2025 huggingface dataset:
EFEKTIVITAS MEDIA ELEARNING MADRASAH TERHADAP MINAT BELAJAR SISWA PADA PEMBELAJARAN SEJARAH
Authors: Jannah Raudatul , Ulfah Maria , Chalimi Ika Rahmatika
Published: October 2022

AbstractThis study aims to determine the effectiveness of madrasah e-learning media on students' interest in learning history in class XI IPS 1 MAN 02 Pontianak. The method used is descriptive quantitative. The results of the study show that 1). effectiveness of madrasah e-learning media in history learning in class XI IPS 1 MAN 02 Pontianak, the results of respondents' answers with the majority of the percentage of 50% in the good category, 2). students' interest in learning using madrasah e-learning media in history learning in class XI IPS 1 MAN 02 Pontianak, the results of respondents' answers with the majority of the percentage of 85% in the sufficient category. 3). Regarding the effectiveness of madrasa e-learning media on students' interest in learning history in class XI IPS 1 MAN 02 Pontianak, it can be concluded of the regression test that the effect of the effectiveness of variable X on Y is 4.2%Keywords: Effectiveness, Madrasah E-learning, History Learning.
PENGEMBANGAN MEDIA MOBILE LEARNING PADA PEMBELAJARAN TEMATIK DI SD NEGERI 02 NGABANG
Authors: Ningsih Natalia Delpia , Sulistyarini Sulistyarini , Priyadi Antonius Totok
Published: October 2022

The purposes of this research are developing and knowing the assessments ofmobile learning media in thematic learning. The research method used is a type ofdevelopment research with the ADDIE development model. The sources ofresearch data are material experts, media experts, from teachers and students ofgrade V SDN 02 Ngabang. The research datas are from the results of thequestionnaire validation sheet of material experts, media experts, teacher responsesheets and grade V students of SDN 02 Ngabang. The results showed that mobilelearning media in thematic learning using the ADDIE development model based onthe assessment of material experts is 84,09% which is in the 71%-85% range with a very feasible category, while the percentage of media experts is 72,73%. which in the 71%-85% range with a decent category, based on the assessment of the teachers' responses, the average of the first rater is 3.55 very effective category, the second rater is 3.6 very effective category, and the third rater is 2.85 effective category, the average students' responses is 3,025 with an effective category, then the mobile learning media is feasible and effective to be used as a medium for thematic learning.Keywords : ADDIE, Media, Mobile Learning.
GAYA HIDUP IMITASI PENGGEMAR DRAMA KOREA DI PROGRAM STUDI PENDIDIKAN SOSIOLOGI FKIP UNIVERSITAS TANJUNGPURA PONTIANAK
Authors: Maryani Benedita Evi , Rustiyarso Rustiyarso , Ismiyani Nining
Published: October 2022

The purpose of this study is to describes the cognitive processes (attention, retention,production of behavior, and motivation) of fans who imitated Korean drama in theSociology Education Study Program, FKIP, Tanjungpura University Pontianak, usingAlbert Bandura's social learning theory. Research approach used qualitative approachdescriptive form. Data collection techniques used are observation, interview, anddocumentation. Data collection tools using observation guides, interview guides,documentation tools. Data analysis techniques used are data reduction, datapresentation, and conclusion. The research analysis was presented descriptivelythrough 3 informants as students of Korean drama fans. The results of this study showedthat the process of fan attention that imitates Korean dramas is the appearance of goodlooking artists, it attracts the attention of informants, from fashionable dress styles tonatural makeup styles. the retention process is watching the drama and updating theartist's social media posts every day in their spare time. Behavioral production processis to imitate fashion in the form of outer knitting, mini dress and natural make up style,by buying a variety of supporting local products that are cheaper in the Indonesianonline marketplace. The motivation of fans is that they want to look stylish and cool likeKorean drama artists. By imitating this, making brands confident because the style ofappearance is in accordance with their tastes.Keywords: Imitation Lifestyle, Korean Drama Fans, Social Learning.
PENGARUH VARIASI LATIHAN TERHADAP SHOOTING PADA PERMAINAN SEPAKBOLA DI KLUB MENSUNGAI UNITED KABUPATEN SAMBAS
Authors: Hidayat Taufik , Atiq Ahmad , Haetami Mimi
Published: October 2022

The lack of ability of football players in mastering shooting techniques, makes theshooting carried out inaccurately towards the goal. Players focus more on kickingspeed so they can shoot quickly without paying attention to foot movements whenkicking the ball into the goal. It is necessary to do special exercises, for example byapplying a variety of exercises to increase the accuracy of players in shooting. Thepurpose of this study was to examine the effect of training variations on shooting atgoal in a soccer game. The research method used is quantitative with primary datatypes. The population in this study is the Mensungai United Football Club, SambasRegency. The collection of samples using total sampling technique and obtained asample of 18 players. Based on the research conducted, the results showed that theaverage value of the pretest was 10 while the average value of the posttest was14.3 with a difference in the average increase of 4.3 or 43%. T-test was used fordata analysis in this study. The calculation results from the T-test showed thatthere was a significant effect between the initial test and the final test. Thesignificance value obtained is 0.000 which is smaller than 0.05. As for the testscarried out, the results obtained that tcount (11,428)> ttable (2,109). From theseresults, it is known that Ha is accepted and H0 is rejected, which means thattraining variations affect shooting at goal in the football game at MensungaiUnited Club, Sambas Regency.Keywords: Variation, Practice, Shooting
KETERAMPILAN TEKNIK DASAR SEPAK BOLA CLUB INDONESIA MUDA PONTIANAK
Authors: Supron Supron , Atiq Ahmad , Purnomo Edi
Published: October 2022

AbstractThe problem in this study is how much basic soccer technical skills are in young Indonesia who have been training in the junior high school field. The research method used is a survey method with a basic soccer skill test for young Indonesian participants consisting of 25 soccer players. There are 5 very good categories with intervals of 26-30 basic soccer dribbling techniques consisting of 20, basic dribbling techniques soccer consists of 25 young Indonesian athletes who have carried out training and tests of basic soccer skills in soccer dribbling where there are 15 athletes in the moderate category with an interval of 26-30 and 5 young Indonesian athletes in the good category with an interval of 20 -25 and 5 athletes in the good category under the 19 second interval, the basic technique of shooting soccer consists of 25 young Indonesian soccer athletes who when given the opportunity to shoot 3 times at the goal the skills produced are still in interval 1 there are 3 athletes, in interval 3 there are 3 athletes, and in interval 5 there were 13 athletes and in interval 7 there were 6 athletes in the very good category.Keywords : Basic Football, Technical Skills.
PENGARUH KEGIATAN MUSYAWARAH GURU MATA PELAJARAN (MGMP) IPS TERHADAP KOMPETENSI PROFESIONAL GURU IPS DI KABUPATEN KAPUAS HULU
Authors: Suryani Suryani , Khosmas F.Y , Syahrudin Husni
Published: October 2022

Abstract This study aims to determine the effect of social studies teacher discussion activity (MGMP) on social science professional competence of junior high school social studies teachers in Kapuas Hulu Regency. This study use a quantitative method with two variables, namely the subject teacher discussion (MGMP) IPS (X) and professional competence (Y). Determination of the sample used is the Slovin formula. The data source of this study was social studies teachers who taught in Kapuas Hulu District with a sample of 57 people. Data collection techniques use consisted of: 1. questionnaire, 1. interview, and 3. documentation. Data were obtained from the results of respondents' questionnaires and from interviews with MGMP administrators and interviews with social studies subjects from the Kapuas Hulu District Education Office. Then do the validity and reliability test, the analysis prerequisite test using the normality test. Next test the hypothesis using simple regression analysis. From the regression results obtained by the equation Y = 0.331 + 0.669 x. then obtained a significance value of 0,000 <0.05 which means there is a positive and significant effect. Obtained results there is a relationship between MGMP activities with a level of professional competence of 0.898 and the magnitude of the contribution of the influence of MGMP R2 (square) activities of 0.806 or 80.06% on professional competence. So there is an influence between MGMP activities with the professional competence of IPS teachers at the Junior High School level in Kapuas Hulu Regency. Keywords: MGMP activities, professional competence
PENGARUH KOMPENSASI DAN IKLIM ORGANISASI TERHADAP KEPUASAN KERJA GURU PAUD DI KECAMATAN PONTIANAK BARAT
Authors: Wulandari Rina , Chiar M , Wahyudi Wahyudi
Published: October 2022

This study focuses on the job satisfaction of PAUD teachers associated with compensation and school organizational climate. The purpose of this study was to determine how the effect of compensation and organizational climate on the job satisfaction of PAUD teachers in West Pontianak. This study uses a quantitative research method with a descriptive approach and the data collection technique uses a questionnaire as a data collection tool. The research sample was PAUD teachers in West Pontianak. This sample was taken based on the determination of a sample of 50 people with the characteristics of having a minimum service period of two years with non-PNS/ASN status. Data were collected using a questionnaire technique with a data collection tool in the form of a list of questionnaires. The instrument composed consists of three variables, namely organizational climate, compensation and job satisfaction of PAUD teachers. In this case, a questionnaire in the form of questions will be distributed to PAUD teachers in West Pontianak District. The data collected was tabulated, then measured using a Likert scale. The data were analyzed using the SPSS 25 program, then tested for validity, reliability, normality, linearity, and hypothesis testing. Based on data analysis, the results of the study were found as follows: (1) compensation has an influence on the job satisfaction of PAUD teachers in West Pontianak District by 40.30%., (2) organizational climate has an influence on job satisfaction of PAUD teachers in West Pontianak District by 5960%, and (3) compensation and organizational climate have a joint influence on the job satisfaction of PAUD teachers in West Pontianak District by 52.50%. The conclusion of this study is that compensation and organizational climate have a joint effect on job satisfaction of PAUD teachers in West Pontianak District by 52.50%. Keywords: Compensation, Job Satisfaction, Organizational Climate
DESIGNING NURSING ENGLISH E-LEARNING MODULE USING SCHOOLOGY AT STIK MUHAMMADIYAH PONTIANAK ACADEMIC YEAR 2018/2019
Authors: Ronas Mahin Ridlo , Salam Uray , Salam Clarry
Published: October 2022

The purpose of the research is to design Nursing English e-learning module using Schoology at STIK Muhammadiyah Pontianak academic Year 2018/2019 and to find out the students’ perception about it. This research is research and development type. By digging the obstacles in the Nursing English class of Regular B, the researcher found the way out that Nursing English e-learning module using Schoology is the solution. The Design of the Nursing English e-learning modul arranged is responded very well by students. To design it the researcher uses ADDIE model. The steps are Analysis, Design, Develope, implementation and Evaluation. By using the e-learning module of Nursing English the students responded very positively.  From all five aspects of practicality assesment of the Nursing English e-learing module namely; effectiveness, creativity, efficiency, Interactivity and attractiveness, the students gave score above 81 % means that they strongly agree to say that the Nursing English e-learning module using Schoology at STIK Muhammadiyah Pontanak Academic Year 2018/2019 is very feasible to use.Keywords: Designing, Nursing English, Schoology, e-learning module
PENGGUNAAN APLIKASI CISCO WEBEX PADA PEMBELAJARAN ONLINE UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA MATERI BESARAN DAN SATUAN DI SMA NEGERI 7 PONTIANAK
Authors: Marbun Jefrison Anelka , Maria Haratua Tiur , B Arsyid Syaiful
Published: October 2022

AbstractThis study aims to determine the effect of using the Cisco Webex application in onlinephysics learning on the material of quantities and units on student learning outcomesat SMA Negeri 7 Pontianak. This research is a quantitative research. The datacollection technique was carried out using pretest-posttest questions. The experimentaldesign used is a pre-experimental design with a one group pretest-posttest design. Thesample in this study was 33 students of class X MIPA 1 for the academic year2021/2022. Statistical analysis used was Shapiro Wilk test to test the normality of thedata, and Wilcoxon signed Rank to test the hypothesis. Based on the student learningoutcomes data, it shows that the Z value (Wilcoxon Signed Rank Test) is -3.244 with ap value (Asymp. Sig 2 tailed) of 0.001. Thus, it can be concluded that there is an increasein student learning outcomes in the material of quantities and units in online learningat SMA Negeri 7 Pontianak after learning using the cisco webex application. So it ishoped that the results of this study can improve the quality of online learning during theCOVID-19 pandemic.Keywords: Cisco Webex Application, Learning Outcomes, Quantities and Units.
PEMANFAATAN MULTIMEDIA PADA MATA PELAJARAN AL-QUR’AN HADITS MATERI MENYANTUNI KAUM DHUAFA DI MAS MAKARIM EL AKHLAQ SINGKAWANG
Authors: Panjaitan Ucok , Fadillah Fadillah , Astuti Indri
Published: October 2022

This study aims to use learning media in MAS Makarim el akhlaq. The results ofthis study are (1) Multimedia de sign of AI-Qur'an subject learning. The material covering  the  poor  is  compiled  starting  from  needs  analysis,  design  designer, making multimedia using power point, this can attract students' interest so that it can increase student learning achievement. (2) The learning process of Al-Qur'an lessons The hadith material helps the poor by utilizing muItimedia already applied to the XI MAS students Makarim El Akhlaq Singkawang well. Based on the discussion of attitudes, responses, and changes in the results of student values, as well as overall student responses to multimedia on average good. (3). Student learning outcomes in the Koran. The hadith material helps the poor to experience improvement after the teacher makes use of multimedia. This is shown from 27 students who reached the minimum completeness criteria number of 70, only 17 students who completed the number of students. After using multimedia learning gains, all students reach KKM above 70. Key words: Utilization of multimedia, Al-Qur'an Hadith, to overwhelm the poor.
PERAN ORANG TUA DALAM MEMOTIVASI BELAJAR PESERTA DIDIK SMP DI DESA SEBETUNG MENYALA KECAMATAN TERIAK KABUPATEN BENGKAYANG
Authors: Arjuna Reno , Mashudi Mashudi , Aminuyati Aminuyati
Published: October 2022

This research aims to determine the role of parents in motivating learning by providing education and providing learning facilities for their children enrolled as junior high school students in Sebetung Menyala Village, Teriak District of Bengkayang Regency. The form of research used in this study is qualitative, with the data sourced from the students’ parents (primary) and photo documentation (secondary). The data collection techniques used are observation, interview, and documentation. The results showed that (1) parents’ roles in motivating learning by providing education to learners are positive, although there are still some parents who do not manage to accompany and remind their children to do schoolwork and lack discipline in learning. (2) The role of parents in motivating learning by providing learning facilities for learners is still insufficient, because there are some unfulfilled learning facilities such as study rooms, tables, and chairs, possibly due to financial problems. However, parents have fulfilled their school needs such as school uniforms, stationery, textbooks, shoes, bags, and pocket money. Keywords: Learning Motivation, Parent’s role, Qualitative Study.
KERJASAMA DALAM KELOMPOK TANI BUDIDAYA II DESA RASAU JAYA TIGA KECAMATAN RASAU JAYA KABUPATEN KUBU RAYA
Authors: Nikmah Khoirun , Bahari Yohanes , Supriyadi Supriyadi
Published: October 2022

This research aims to determine the forms of direct cooperation, contractualcooperation and traditional cooperation in the Budidaya II Farmers Group RasauJaya Tiga Village. The method used is descriptive qualitative. The methods of datacollection is using a observation methods, interview and documentation tools. Thetools of data collection is a observation guides, interview guides, and documentation.Testing of Data validity is an extension observation, and triangulation. The results ofthe research showed that the cooperation carried out in the Budidaya II FarmerGroup in the form of direct, contract and Traditional has been carried out. It isproved that there is a form of direct cooperation in the form of directives given by thechairman to its members, then a form of contractual cooperation in the form ofagreements that have been approved by all members of the group such as the holdingof meetings every month, setting monthly contributions and further a form oftraditional cooperation in which all members of the group work together in landclearing, seeding, care and harvesting of agricultural products.Keywords: Cooperation, Farmer, Farmer Groups
Spectrally-selective Time-resolved Emission through Fourier-filtering (STEF)
Authors: Sica Anthony , Atallah Timothy , Caram Justin
Published: October 2022

In this manuscript we demonstrate that directing the emitted photon stream from a fluorescent sample through a fixed path-length imbalanced Mach-Zehnder interferometer allows us to separate and resolve the dynamics of different emitters without the use of filtering optics. Our method, Spectrallyselective Time-resolved Emission through Fourier-filtering (STEF) takes advantage of a careful selection of interferometer position where one signal can be canceled (or enhanced) due to its unique spectral characteristics. STEF is straightforward to implement and provides a complementary approach to separate spectrally overlapped signals based on their coherence length and carrier frequency. We also discuss how one can implement STEF with an imperfect Mach-Zehnder interferometer, increasing the utility of this method, and demonstrate how Mach-Zehnder filtering can be used to image fluorophores in biologically relevant samples.
Prebiotic Synthesis on Meteorite Parent Bodies: Insights from Hydrogen and Carbon Isotope Models
Authors: Chimiak Laura , Eiler John
Published: October 2022

Several mechanisms could produce the biorelevant compounds in carbonaceous meteorites. These include radiation-driven reactions in the interstellar medium, gas-phase mineral-catalyzed reactions in the solar nebula, and aqueous chemistry in meteorite parent bodies. The ratio of heavy-to-light isotopes in a compound can constrains its formation history: a reaction’s substrates, mechanisms, and physiochemical conditions impact isotope ratios. Studies of the stable isotope compositions of meteoritic organic compounds have focused on sample- and molecular-average isotope measurements and have interpreted those data via qualitative or semi-quantitative models. Here we create quantitative models (i.e., explicitly fit to measurements) for hydrogen and carbon isotope compositions of organic compounds in primitive carbonaceous meteorites and use these models to reach broader conclusions regarding the environments, substrates, and chemical processes that contributed to pre- and early-solar-system organic synthesis. The hydrogen model fits measured molecular-average deuterium concentrations in a compound class (e.g., amines, carboxylic acids) as linear combinations of hydrogens with similar chemical environments. In the chondrites studied, methyl hydrogens are amongst the most deuterium-enriched moiety and hydrogens attached to α-carbons are the least. Deuterium enrichment is inversely related to both a compound class’s water solubility and a meteorite sample’s degree of aqueous alteration and terrestrial weathering. These values suggest that ISM-sourced compounds reacted to form deuterium-enriched molecules on meteorites’ parent bodies and the enrichments were attenuated through exchange with water during aqueous alteration on the parent body and subsequent terrestrial processing. The carbon model fits the δ13CVPDB of products from various reaction mechanisms by applying isotope effects to reactant δ13C measurements. The model with the most accurate δ13C fits of the compounds in the Murchison meteorite (62 % of previous measurements fit by model) and the lowest average residuals (5 ‰) uses the integrated aldehyde network (oxidation, reductive amination, and Strecker synthesis on aldehydes and ketones) to produce straight-chain compounds that undergo formaldehyde addition to create branched-chain compounds. Formaldehyde addition has not been previously considered in prebiotic chemical reaction networks, but the best-fit network’s ability to fit compounds that span over 100 ‰ in carbon isotope abundances makes it an attractive chemistry to explore.
Conformational preference analysis in C2H6 using Orbital Forces and Non-Covalent Interactions; comparison with related systems
Authors: Novoa Trinidad , Contreras-Garcia Julia , Chaquin Patrick
Published: October 2022

Dynamic Orbital Forces (DOF) and Non-Covalent Interactions (NCIs) allow an analysis of the attractive/repulsive interactions whose variations lead to the staggered preference of ethane and some related compounds. In ethane, it is found that CH3···CH3 attractive interactions are predominant in the staggered preference with respect to adiabatic eclipsed conformation, with an important  contribution. On the contrary, vertical eclipsed ethane is destabilized almost only by repulsive  interactions. Weak long-range H···H repulsions favor the staggered conformation. From the sum of DOFs, the energy barrier can be decomposed into C-H and C-C bond energies. It is found due to the weakening of the C-C bond (ca. 7 kcal/mol), moderated by a strengthening of C-H ones (ca. 4 kcal/mol) arising from the decrease of hyperconjugation with respect to the staggered conformation. In the compounds CH3-SiH3, SiH3-SiH3, CH3-CF3 and CF3-CF3, the conformational preference is predominantly or exclusively due to repulsive interactions, with respect as well to adiabatic as to vertical eclipsed structures.
Supermolecular Ferroelectric Nematic Materials
Authors: Mandle Richard
Published: October 2022

The discovery of a new nematic phase variant with polar order and ferroelectricity, the NF phase, is a significant milestone in soft matter research. Herein we describe the preparation of hydrogen-bonded complexes between 4-(2,4-dimethoxybenzoyloxy)benzoic acid and either 4-nitropyridine or 3-fluoro-4-nitropyridine, these being analogous in structure to the archetypal NF material RM734. Complexes were isolated using a semi-automated process we term Machine Vision Aided Crystallisation. We find these complexes exhibit classical and polar (NF) nematic phases despite the large reduction in electric dipole moment that results from swapping a phenyl ring for 4-pyridyl. DFT calculations support the hypothesis that the onset of polar order is not simply a product of electric dipole magnitude, but rather
A comparison of photodeposited RuOx for alkaline water electrolysis
Authors: Daly Katelynn , Jimenez-Villegas Santiago , Godwin Benjamin , Schoen Martin , Calderon Oliver , Chen Ning , Trudel Simon
Published: October 2022

The storage of renewable energy is a pressing challenge to overcome in the transition towards a power grid based on plentiful, yet intermittent energy supplies. The renewables-driven electrolysis ofwater to formhydrogen fuel is an attractive avenue, but requires better oxygen-evolution reaction (OER) catalysts to be feasible at scale. RuO2 is touted as one of the superior OER catalysts, but only under acidic conditions – RuO2 electrocatalysts suffer from poor stability under alkaline conditions. In this work, we evaluate three photodeposited RuO2 OER electrocatalysts, all prepared via a scalable photodeposition method. Based on electrochemical and spectroscopic studies (x-ray photoelectron spectroscopy and X-ray absorption spectroscopy) our main findings are that nanocrystalline RuO2 catalysts outperform their amorphous counterpart, and are stable under alkaline (0.1 M KOH) conditions. This works thus lifts a major hurdle towards the use of RuO2 for alkaline water electrolysis.
N-Carboxyanhydrides Directly from Amino Acids and Carbon Dioxide and their Tandem Reactions to Therapeutic Alkaloids
Authors: Tran Thi , Shen Yi , Nguyen Hieu , Deng Shijie , Roshandel Hootan , Cooper Mason , Watson Jose , Byers Jeffery , Diaconescu Paula , Do Loi
Published: October 2022

We report on the preparation of synthetically versatile N-carboxyanhydrides (NCAs) directly from amino acids and CO2 using n-propylphosphonic anhydride. Most of the NCAs were isolated with >95% purity after simple workup, avoiding the need for tedious purification procedures typically required using conventional methods. Because the reagents and conditions employed are mild, tandem reactions with moisture-sensitive NCAs were carried out to transform them into the medicinally active alkaloids tryptanthrin and phaitanthrin A in one pot. A qualitative analysis revealed that our NCA synthesis approach is more green than conventional methods, which all directly or indirectly use the highly poisonous gas phosgene.
“Magic” sinter-resistant cluster sizes of Ptn supported on Alumina
Authors: Poths Patricia , Hong Zixiang , Li Guangjing , Anderson Scott L. , Alexandrova Anastassia N.
Published: October 2022

Subnano cluster catalysts, while highly promising due to unique activity, selectivity, and atom-efficiency, are limited in wider applications, as they are prone to deactivation via sintering. Even size-selection, which was previously shown to reduce sintering of nanoparticles, cannot reduce the sintering of highly fluxional subnano clusters, due to their inherent isomeric diversity. Here, we use a combination of theory and experiment to show that Pt clusters on Al2O3 exhibit size-dependent sintering resistance. We furthermore show that Pt4/Al2O3 and Pt7/Al2O3 are “magic” sinter-resistant cluster sizes. Their stability is attributed to the greater degree of bulk-like crystallinity of the dominant isomers. In addition, we identify different spatial signatures characteristic of the sintering of clusters with differing sintering stabilities.
Enhanced Sampling Aided Design of Molecular Photoswitches
Authors: Raucci Umberto , Sanchez David M. , Martinez Todd J. , Parrinello Michele
Published: October 2022

Advances in the evolving field of atomistic simulations provide continuous insights for the design and fundamental understanding of novel molecular photoswitches. Here, we use state-of-the-art enhanced simulation techniques to unravel the complex, multistep chemistry of donor-acceptor Stenhouse adducts (DASAs), revealing a plethora of newly discovered thermal pathways. We use enhanced sampling simulations to drive reaction discovery, followed by refinement of newly observed pathways with more accurate ab initio electronic structure calculations, and then structural modifications to introduce design principles in new generations of DASAs. We illustrate tunability of these newly discovered reactions, leading to a potential avenue for controlling DASA dynamics through multiple external stimuli. Overall, these insights could offer alternative routes to increase the efficiency and control of DASA’s photoswitching mechanism, providing new elements to design more complex light-responsive materials.
Judicious Heteroatom Doping Produces High Performance Deep Blue Multiresonant Thermally Activated Delayed Fluorescence Organic Light-Emitting Diodes
Authors: Madayanad Suresh Subeesh , Zhang Le , Matulaitis Tomas , Hall David , Si Changfeng , Slawin Alexandra , Warriner Stuart , Beljonne David , Olivier Yoann , Samuel Ifor , Zysman-Colman Eli
Published: October 2022

We show how borylation of an acceptor-donor-acceptor (A-D-A) thermally activated delayed fluorescence (TADF) emitter, DIDOBNA-N, transforms the compound into a multi-resonant TADF (MR-TADF) emitter, MesB-DIDOBNA-N. DIDOBNA-N emits bright blue light (𝜆PL = 444 nm, FWHM = 64 nm, 𝛷PL = 81%, 𝜏d = 23 𝜇s, 1.5 wt% in TSPO1). The deep blue organic light-emitting diode (OLED) based on this compound shows a very high maximum external quantum efficiency (EQEmax) of 15.3% for a device with CIEy of 0.073. The MR-TADF emitter, MesB-DIDOBNA-N shows efficient and narrowband violet emission (𝜆PL = 402 nm, FWHM = 19 nm, 𝛷PL = 74.7%, 𝜏d = 133 𝜇s, 1.5 wt% in TSPO1). The OLED with MesB-DIDOBNA-N shows out-standing efficiency for a violet OLED at 9.3% and CIEy = 0.044, which is the bluest EL reported for a MR-TADF OLED to date. Noteworthy are the CIE coordinates of (0.166, 0.045), which are very close to the Rec.2020 standard for blue (0.131, 0.046). The EQEmax values were improved from 9.3% to 13.6% by increasing the concentration of the emitter in the host from 1.5 wt% to 5 wt%.
Multivariate tiered approach to highlight the link between large-scale integrated pesticide concentrations from POCIS and watershed land-uses
Authors: Bernard Marion , Boutry Sébastien , Guibal Robin , Morin Soizic , Lissalde Sophie , Guibaud Gilles , Saüt Margaux , Rebillard Jean-Pierre , Mazzella Nicolas
Published: October 2022

This paper describes an automatized multi-step methodology in order to identify the relationships between integrative pesticide quantifications and land-use on a given watershed. This methodology contains multivariate statistical analyses such as hierarchical cluster analysis (HCA) and principal component analysis (PCA), which are commonly used for the interpretation of complex geospatial datasets. A large amount of pesticide concentration data were collected along 1-year monitoring in 2016, for 50 sites located on the Adour Garonne basin (South-West France). For those sampling sites, concentrations of 37 selected pesticides were investigated during six periods of 14-days immersion of integrative samplers. Specifically, the sampling devices used were Polar Organic Chemical Integrative Sampler (POCIS), providing time-weighted average concentration estimates. For each studied site, the associated watershed and its land-use repartition were determined based on the Corine Land Cover 2012 and geographical information system (GIS) aggregation of data. The HCA clustered the 50 sites into five groups with similar main land uses. After that, the datasets of pesticide integrated concentration and land use repartition were analyzed in a PCA. The key variables (pesticide distribution and concentrations) responsible for sampling site discrimination showed consistent patterns of distribution with specific land uses. In order to confirm these observations, pesticide fingerprints (based on the waffle method) of sites with contrasted land use relative to the surface areas were compared. These fingerprints confirmed that there was different and specific patterns, visible at a glance, of pesticide occurrence in surface water, in relation with their initial use at the catchment level. This method allowed identifying sources of contamination that could be interesting to prevent or contain pesticide pollutions beyond simply acting on the most at-risk areas.
Plant Terpenoid Permeability through Biological Membranes Explored via Molecular Simulations
Authors: Raza Saad , Miller Mykayla , Hamberger Björn , Vermaas Josh
Published: October 2022

Plants synthesize small molecule diterpenes comprised of twenty carbon from precursors isopentenyl diphosphate and dimethylallyl disphosphate, manufacturing diverse compounds used for defense, signaling, and other functions. Industrially, diterpenes are used as natural aromas and flavoring, as pharmaceuticals, and as natural insecticides or repellents. Despite diterpene ubiquity in plant systems, it remains unknown how plants control diterpene localization and transport. For many other small molecules, plant cells maintain transport proteins that control compound compartmentalization. However, for most diterpene compounds, specific transport proteins have not been identified, and so it has been hypothesized that diterpene may cross biological membranes passively. Through molecular simulation, we study membrane transport for three complex diterpenes from among the many made by members of the Lamiaceae family to determine their permeability coefficient across plasma membrane models. To facilitate accurate simulation, the intermolecular interactions for leubethanol, abietic acid, and sclareol were parameterized through the standard CHARMM methodology for incorporation into molecular simulations. To evaluate the effect of membrane composition on permeability, we simulate the three diterpenes in two membrane models derived from sorghum and yeast lipidomics data. We track permeation events within our unbiased simulations, and compare implied permeation coefficients with those calculated from Replica Exchange Umbrella Sampling calculations using the inhomogeneous solubility diffusion model. The diterpenes are observed to permeate freely through these membranes, indicating that a transport protein may not be needed to export these small molecules from plant cells. Moreover, the permeability is observed to be greater for plant-like membrane compositions when compared against animal-like membrane models. Increased permeability for diterpene molecules in plant membranes suggest that plants have tailored their membranes to facilitate low-energy transport processes for signaling molecules.
MOLECULAR MODIFICATION OF CO-TRIMOXAZOLE, TETRACYCLINE, ASPIRIN IN COMBINATION WITH PSIDIUM GUAJAVA AND SYZYGIUM AROMATICUM FOR TREATMENT OF CLINICAL RESISTANT SALMONELLA INFECTION : CASE STUDY KAKURI NIGERIA.
Authors: Gideon Mathew , Duniya Emmanuel Kambai , Mamman Abakeyah James , Dennis Samuel
Published: October 2022

For centuries plant extract has been used for treatments of various diseases, medicinal plants has also been the source of many active components of prescribe drugs. Drug resistant Salmonella infections has been of growing concern in Nigeria due to regular dosing by self-medication. The aim of this work is to identify a novel compounds with potentially improved antimicrobial activities by molecular modification of ineffective antibiotics and non-antibiotics using aqueous plant extract for the treatment of resistant salmonella spp at lower concentration. Co-trimoxazole, Tetracycline and Aspirin at 10 µg/mL were synthetically combine with water extract of Cloves and Guava leaves in three different stages using concentrated sulphuric acid and sodium hydroxide, 31 antimicrobial disk were prepared and tested on salmonella spp. Scl, a one-step combination of co-trimoxazole with clove extract, Ac2 a two-step combinatorial synthesis of aspirin with clove extract, Ag2 a two-step combinatorial synthesis of Aspirin with guava leave extract were all susceptible to resistant salmonella spp with clear zones of inhibition at 10 µg/mL better than Ciprofloxacin at 20 µg/mL. no inhibition shown by A10, T10, S10, Gu, Cl, Agu, Tgu, Sgu, Tcl, Scl, Ag1, Tg1, Sg1, Ac1, Tc1, Tg2, Sg2, Tc2, Sc2, Ag3, Tg3, Sg3, Ac3, Tc3 and Sc3. Aspirin was the best precursor drug which combine synthetically with both clove and guava extract to give a carrier product with desired antimicrobial properties, hence the need for isolation purification and further clinical trials.
Bioactive hard protein coronas on poly(propylene sulfone) surfaces enable mast cell nanotherapy
Authors: Du Fanfan , Rische Clayton , Li Yang , Vincent Michael , Qian Yuan , Yuk Simseok , Almunif Sultan , Bochner Bruce , Qiao Baofu , Scott Evan
Published: October 2022

Contact between nanomaterials and biomolecules such as serum proteins leads to “soft” or “hard” corona formation via dynamic or irreversible adsorption, respectively. While soft coronas of antibodies can temporarily retain the ability for immunological recognition, preserving protein function within hard coronas has remained an elusive goal due to the unfolding of protein at the nano-bio interface. Here, we show that poly(propylene sulfone) nanoparticles efficiently and stably adsorb proteins, unexpectedly forming bioactive hard coronas using a facile methodology. This process is permitted by site-specific hydrophobic-hydrophobic interactions between nanoparticle surfaces and proteins, allowing stable simultaneous pre-adsorption of multiple proteins such as enzymes and antibodies. For therapeutic validation, a nanotherapy for enhanced antibody-based targeting of mast cells and inhibition of anaphylaxis was demonstrated in a humanized mouse model. Protein immobilization on the poly(propylene sulfone) surface therefore provides a simple and rapid platform for the design, fabrication, and optimization of bioactive and targeted nanomedicines.
Chemodivergent C(sp3)–H and C(sp2)–H Cyanomethylation Using Engineered Carbene Transferases
Authors: Zhang Juner , Maggiolo Ailiena , Alfonzo Edwin , Mao Runze , Porter Nicholas , Abney Nayla , Arnold Frances
Published: October 2022

The ubiquity of C–H bonds presents an attractive opportunity to elaborate and build complexity in organic molecules. Methods for selective functionalization, however, often must differentiate among multiple chemically similar and, in some cases indistinguishable, C–H bonds within the same molecule. An advantage of enzymes is that they can be finely tuned using directed evolution to achieve control over divergent C–H functionalization pathways. Here, we present engineered enzymes that effect a new-to-nature C–H alkylation (C–H carbene insertion) with unparalleled selectivity: two complementary carbene C–H transferases derived from a cytochrome P450 from Bacillus megaterium deliver an α-cyanocarbene into the α-amino C(sp3)–H bonds or the ortho-arene C(sp2)–H bonds of N-substituted arenes. These two transformations proceed via different mechanisms, yet only minimal changes to the protein scaffold (nine mutations, less than 2% of the sequence) were needed to adjust the enzyme’s control over the site-selectivity of cyanomethylation. The X-ray crystal structure of the selective C(sp3)–H alkylase, P411-PFA, reveals an unprecedented helical disruption which alters the shape and electrostatics in the enzyme active site. Overall, this work demonstrates the advantages of using enzymes as C–H functionalization catalysts for divergent molecular derivatization.
Universal link between polymer and glass physics inferred from double glass transitions in small–molecule liquids
Authors: Russell Ben , Tukachev Nikita , González-Jiménez Mario , Hayes Laure-Anne , Chowdhury Tajrian , Javornik Uroš , Mali Gregor , Farnaby Joy , Tassieri Manlio , Senn Hans , Wynne Klaas
Published: October 2022

At the glass transition, a supercooled liquid vitrifies into an amorphous solid and all viscous relaxation processes cease. The experimental observation of secondary or β relaxations below the glass transition temperature in molecular and metallic glasses suggests that this picture may be somewhat oversimplified but essentially correct. Polymers, on the other hand, are thought of as fundamentally different: on cooling, polymers typically show a cascade of transitions from a viscous liquid, through viscoelastic fluid and viscoelastic solid stages, and finally a brittle glass. Here we show that a family of homogeneous non-polymeric liquids—titanium tetraalkoxides—have double glass transitions giving rise to two distinct steps in the temperature-dependent heat capacities. The double glass transition causes the liquid to transition from viscous to viscoelastic to elastic, like a simple polymer liquid. This result allows us to link the physical behaviour of polymers and small-molecule glass formers in a single universal picture.
Dos casos de estudio de centros de educación especial para niños con discapacidad: "el colegio Fray Pedro Ponce de León" y "la escuela Hazelwood"
Authors: Vera Gómez Karla
Published: October 2022

Este artículo es un análisis sobre arquitectura relacionada con educación especial, a través del estudio de dos centros educativos ubicados en las ciudades de Burgos (España) y Glasgow (Reino Unido), respectivamente: el Colegio Público de Educación Especial Fray Pedro Ponce de León y la escuela Hazelwood (Hazelwood School). Ambos centros se evaluarán sobre la base de los siguientes criterios para determinar si son accesibles en su totalidad para un usuario con discapacidad: ubicación y emplazamiento; impacto social; relación entre el usuario y el espacio público; estrategias proyectuales; programa y áreas; y sistema constructivo y tecnologías.
EFFECT OF FOUR BIOCHAR TYPES AND INORGANIC PHOSPHATE FERTILIZER ON GROWTH AND NODULATION OF SOYBEAN (GLYCINE MAX (L.) MOENCH)
Authors: A.A. Adekanmbi, , F. Oghenewiro, , J. A Fagbenro, , A. Bala, , O. A. Osunde,
Published: October 2022

There is a compelling need to explore the use of biochar as a sustainable alternative to the use of chemical or mineral fertilizer amendment in the contexts of soybean cropping system in Sub-Sahara Africa. A pot experiment was conducted to evaluate the effects of poultry manure biochar (PB), swine dung biochar (DB), maize cob biochar (MB), saw dust biochar (SB) and inorganic phosphate fertilizer (single supper phosphate) applied singly on the growth and nodulation of soybean in Minna, southern Guinea savanna zone of Nigeria. The biochars were applied at four levels of 0, 5, 10, and 15 t ha-1 while single supper phosphate (SSP) was applied at 30 kg P ha-1. The experimental design was a completely randomized design (CRD) with three replications. The results showed that soybean plant parameters of height, number of leaves, number and dry weight of nodules, shoot, root and total dry biomass increased in all treatments that received animal waste biochars (PB & DB) over the non-treated control (0 t ha-1) except the plant root length and shoot/root ratio. However, the difference was statistically significant (p<0.05) only at the higher application level of 10 t ha-1. Plant-based biochars (MB & SB) were less beneficial to soybean plant, and their influence on soybean parameters did not differ significantly from non-treated control. Soybean plant also responded positively to the application of SSP but was significantly better than the control only for plant height. The results showed that animal waste-derived biochars were more beneficial to soybean plant in terms of nodulation and growth than the plant-based biochars and SSP fertilizer. Evidence that soyabean growth, biomass accumulation and nodulation benefit more from amending soil medium planted to soyabean with manure based biochars applied at 10 tons ha-1 compared to the plant-based biochar showed that, manure base biochars are more suitable as soil amendments for legumes like soyabean that require more P and less amount of N in their nutrition.
IMPACT OF ORGANIC AND INORGANIC FERTILIZER ON THE PERFORMANCE OF INDIAN SPINACH AND RED AMARANTH IN FLOATING BED IN SUMMER SEASON
Authors: Mondal Asit Baran , Ahmed Mohammad Bashir , Mannan Md. Abdul
Published: October 2022

The study was undertaken to investigate the performance of organic and inorganic fertilizers in floating bed on the development and yield of Indian spinach and red amaranth in 2014 and 2015 in Gopalganj, Bangladesh. The single factor experiment was conducted in Randomized Complete Block Design (RCBD) with three replications. There were four treatments like control, cowdung, suggested dose of NPK, fifty percent cowdung + fifty percent suggested dose of NPK. Organic and inorganic fertilizers have positive impact in floating bed for the performance of Indian spinach and red amaranth. In case of Indian spinach, the higheststem length (187.17 and 185.33 cm, respectively) was found in fifty percent cow dung + fifty percent suggested dose of NPK. The highest weight of leaves varied from 567.00 and 521.33 to 853.67 and 843.00 g while the total weight of stems varied from 686.67 and 694.00 to 1009.33 and 998.67 g in 2014 and 2015, respectively. The highest yield (57.30 and 55.60 t ha-1, respectively) was obtained from suggested dose of NPK followed by fifty percent Cow dung + fifty percent suggested dose of NPK. The minimum yield (37.60 and 36.50 t ha-1, respectively) was obtained within the control in 2014 & 2015. Similar tendency was also observed in red amaranth in both the growing season. Including economic consideration, the results suggested that the use of fifty percent cow dung + fifty percent NPK of suggested dose of fertilizers in floating bed was appropriate for development and yield as well as cost effective for Indian spinach and red amaranth production.
Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus
Authors: Muslimov Ilham A , Berardi Valerio , Stephenson Stacy , Ginzler Ellen M , Hanly John G , Tiedge Henri
Published: October 2022

Lupus autoimmunity frequently presents with neuropsychiatric manifestations, but underlying etiology remains poorly understood. Human brain cytoplasmic 200 RNA (BC200 RNA) is a translational regulator in neuronal synapto-dendritic domains. Here, we show that a BC200 guanosine-adenosine dendritic transport motif is recognized by autoantibodies from a subset of neuropsychiatric lupus patients. These autoantibodies impact BC200 functionality by quasi irreversibly displacing two RNA transport factors from the guanosine-adenosine transport motif. Such anti-BC autoantibodies, which can gain access to brains of neuropsychiatric lupus patients, give rise to clinical manifestations including seizures. To establish causality, naive mice with a permeabilized blood–brain barrier were injected with anti-BC autoantibodies from lupus patients with seizures. Animals so injected developed seizure susceptibility with high mortality. Seizure activity was entirely precluded when animals were injected with lupus anti-BC autoantibodies together with BC200 decoy autoantigen. Seizures are a common clinical manifestation in neuropsychiatric lupus, and our work identifies anti-BC autoantibody activity as a mechanistic cause. The results demonstrate potential utility of BC200 decoys for autoantibody-specific therapeutic interventions in neuropsychiatric lupus.
Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy
Authors: Hlaváč Viktor , Holý Petr , Václavíková Radka , Rob Lukáš , Hruda Martin , Mrhalová Marcela , Černaj Petr , Bouda Jiří , Souček Pavel
Published: October 2022

Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected EOC. Compared with sensitive patients, platinum-resistant patients had a significantly higher somatic mutational rate inTP53and lower in several genes from the Hippo pathway. We confirmed the pivotal role of somatic mutations in homologous recombination repair genes in platinum sensitivity and favorable prognosis of EOC patients. Implementing the germline homologous recombination repair profile significantly improved the prediction. In addition, distinct mutational signatures, for example, SBS6, and overall mutational load, somatic mutations inPABPC1,PABPC3, andTFAMco-segregated with the resistance status, high-grade serous carcinoma subtype, or overall survival of patients. We generated germline and somatic genetic landscapes of prognostically different subgroups of EOC patients for further follow-up studies focused on utilizing the observed associations in precision oncology.