bluuebunny/crossref_metadata_2025 huggingface dataset:
Informatics in Undergraduate Medical Education: Analysis of Competency Frameworks and Practices Across North America
Authors: Chartash David , Rosenman Marc , Wang Karen , Chen Elizabeth
Published: September 2022

Background

With the advent of competency-based medical education, as well as Canadian efforts to include clinical informatics within undergraduate medical education, competency frameworks in the United States have not emphasized the skills associated with clinical informatics pertinent to the broader practice of medicine.

Objective

By examining the competency frameworks with which undergraduate medical education in clinical informatics has been developed in Canada and the United States, we hypothesized that there is a gap: the lack of a unified competency set and frame for clinical informatics education across North America.

Methods

We performed directional competency mapping between Canadian and American graduate clinical informatics competencies and general graduate medical education competencies. Directional competency mapping was performed between Canadian roles and American common program requirements using keyword matching at the subcompetency and enabling competency levels. In addition, for general graduate medical education competencies, the Physician Competency Reference Set developed for the Liaison Committee on Medical Education was used as a direct means of computing the ontological overlap between competency frameworks.

Results

Upon mapping Canadian roles to American competencies via both undergraduate and graduate medical education competency frameworks, the difference in focus between the 2 countries can be thematically described as a difference between the concepts of clinical and management reasoning.

Conclusions

We suggest that the development or deployment of informatics competencies in undergraduate medical education should focus on 3 items: the teaching of diagnostic reasoning, such that the information tasks that comprise both clinical and management reasoning can be discussed; precision medical education, where informatics can provide for more fine-grained evaluation; and assessment methods to support traditional pedagogical efforts (both at the bedside and beyond). Assessment using cases or structured assessments (eg, Objective Structured Clinical Examinations) would help students draw parallels between clinical informatics and fundamental clinical subjects and would better emphasize the cognitive techniques taught through informatics.
Examining the Twitter Discourse on Dementia During Alzheimer’s Awareness Month in Canada: Infodemiology Study
Authors: Bacsu Juanita-Dawne , Cammer Allison , Ahmadi Soheila , Azizi Mehrnoosh , Grewal Karl S , Green Shoshana , Gowda-Sookochoff Rory , Berger Corinne , Knight Sheida , Spiteri Raymond J , O'Connell Megan E
Published: September 2022

Background

Twitter has become a primary platform for public health campaigns, ranging from mental health awareness week to diabetes awareness month. However, there is a paucity of knowledge about how Twitter is being used during health campaigns, especially for Alzheimer’s Awareness Month.

Objective

The purpose of our study was to examine dementia discourse during Canada’s Alzheimer’s Awareness Month in January to inform future awareness campaigns.

Methods

We collected 1289 relevant tweets using the Twint application in Python from January 1 to January 31, 2022. Thematic analysis was used to analyze the data.

Results

Guided by our analysis, 4 primary themes were identified: dementia education and advocacy, fundraising and promotion, experiences of dementia, and opportunities for future actions.

Conclusions

Although our study identified many educational, promotional, and fundraising tweets to support dementia awareness, we also found numerous tweets with cursory messaging (ie, simply referencing January as Alzheimer’s Awareness Month in Canada). While these tweets promoted general awareness, they also highlight an opportunity for targeted educational content to counter stigmatizing messages and misinformation about dementia. In addition, awareness strategies partnering with diverse stakeholders (such as celebrities, social media influencers, and people living with dementia and their care partners) may play a pivotal role in fostering dementia dialogue and education. Further research is needed to develop, implement, and evaluate dementia awareness strategies on Twitter. Increased knowledge, partnerships, and research are essential to enhancing dementia awareness during Canada’s Alzheimer’s Awareness Month and beyond.
Occupational Health Hazards Among Traffic Police in South Asian Countries: Protocol for a Scoping Review (Preprint)
Authors: Jahan Ishrat , Dalal Koustuv , Khan Md Abdullah Saeed , Mutsuddi Archi , Sultana Sabeeha , Rashid Md Utba , Haque Miah Md Akiful , Hossain Mohammad Ali , Hossian Mosharop , Nabi Mohammad Hayatun , Hawlader Mohammad Delwer Hossain
Published: September 2022

BACKGROUND

Occupational health hazards and injuries are an alarming concern among traffic police. Occupational injuries affect the physical, social, and mental well-being of police personnel, which has various public health implications. The evaluation of occupational health and safety policies and regulations for the traffic police relies on their occupational exposure and health hazard statistics and assessments.

OBJECTIVE

The purpose of this scoping review is to systematically explore, analyze, and describe relevant findings from all studies conducted on occupational exposure and associated health hazards among traffic police in South Asia.

METHODS

The scoping review will include studies that assessed occupational exposure prevalence, types, knowledge, predisposing factors, and prevention strategies. Databases like PubMed, Springer Link, EBSCOhost, the Cochrane library, and Google Scholar will be used to obtain both published and unpublished works in the English language. Relevant gray literature, including governmental and international organization reports, will be examined. After removing duplicates and screening titles and abstracts, the full-text analysis will begin. Arksey and O'Malley's methodology framework for scoping reviews will be followed. According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, the scoping review will be reported. Two qualified reviewers will independently conduct article screening and data extraction. The extracted data will then be tabulated and accompanied by an explanation to facilitate comprehension. We will extract relevant article results using NVivo (version 10; QSR International) and thematic content analysis. The included articles will be evaluated using the mixed methods appraisal tool (version 2018).

RESULTS

The scoping review will provide insight into how occupational health hazards affect traffic police physically and psychologically in South Asia. The theoretical conceptualization of different aspects of the occupational health of traffic police will emphasize future studies in this region, which will inform policy makers to revise their occupational health and safety policies and principles. It will have implications for taking necessary preventive measures in the future to reduce occupational injuries and fatalities resulting from different types of occupational hazards.

CONCLUSIONS

This scoping review will describe the overview of occupational hazards among South Asian traffic police and will provide insights for policy makers to implement changes and to adapt new strategies.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/42239
Using Decision Trees as an Expert System for Clinical Decision Support for COVID-19 (Preprint)
Authors: Chrimes Dillon
Published: September 2022

UNSTRUCTURED

COVID-19 has impacted billions of people and health care systems globally. However, there is currently no publicly available chatbot for patients and care providers to determine the potential severity of a COVID-19 infection or the possible biological system responses and comorbidities that can contribute to the development of severe cases of COVID-19. This preliminary investigation assesses this lack of a COVID-19 case-by-case chatbot into consideration when building a decision tree with binary classification that was stratified by age and body system, viral infection, comorbidities, and any manifestations. After reviewing the relevant literature, a decision tree was constructed using a suite of tools to build a stratified framework for a chatbot application and interaction with users. A total of 212 nodes were established that were stratified from lung to heart conditions along body systems, medical conditions, comorbidities, and relevant manifestations described in the literature. This resulted in a possible 63,360 scenarios, offering a method toward understanding the data needed to validate the decision tree and highlighting the complicated nature of severe cases of COVID-19. The decision tree confirms that stratification of the viral infection with the body system while incorporating comorbidities and manifestations strengthens the framework. Despite limitations of a viable clinical decision tree for COVID-19 cases, this prototype application provides insight into the type of data required for effective decision support.
Adaptation of an Adult Web Application for Type 1 Diabetes Self-management to Youth Using the Behavior Change Wheel to Tailor the Needs of Health Care Transition: Qualitative Interview Study (Preprint)
Authors: Xie Li Feng , Housni Asmaa , Nakhla Meranda , Cianci Rosemarie , Leroux Catherine , Da Costa Deborah , Brazeau Anne-Sophie
Published: September 2022

BACKGROUND

Youth (aged 14-24 years) living with type 1 diabetes (T1D) encounter increased challenges in their diabetes self-management (DSM), especially during the transition to adult care. Although DSM education and support are imperative, there is insufficient information on how web-based digital tools tailored to their demands can be developed.

OBJECTIVE

On the basis of the Behavior Change Wheel, this study aims to identify, among youth living with T1D, the needs and factors influencing their DSM in the context of health care transition and to inform the adaptation (content and features) of an adult self-guided web application (Support).

METHODS

Internet-based semistructured individual interviews based on a phenomenological study design were conducted with 21 youths, and transcripts were analyzed using an inductive approach with concept mapping.

RESULTS

Factors influencing T1D self-management were categorized into barriers and facilitators and then as external or internal. Features influencing the accessibility to information, increasing the sense of support, and use of the tool were positively accepted. Features unrelated to their expectations of digital tool use or difficulty navigating were viewed negatively. Participants expressed an interest in reliable, practical, and novel educational content. Although youth considered the information provided by medical professionals to be important, peer exchange was deemed necessary to obtain a practical perspective and real-life examples.

CONCLUSIONS

Compared with the adult population, in addition to tailored content and a simplified information search process, when building a DSM education and support digital tool for youth, features should be selected to encourage supervised peer exchange.

CLINICALTRIAL
Analisis Kekerabatan dan Keragaman Dua Puluh Lima Tanaman Sri Rejeki (Aglaonema sp) Berdasarkan Karakter Morfologi
Authors: Renaldi Irwan Gery , Purwantoro Aziz
Published: September 2022

Dalam program perakitan varietas tanaman aglaonema unggul memerlukan beberapa informasi dasar sebagai bahan penentu arah pemuliaan tanaman. Melalui penelitian ini dilakukan karakterisasi berdasarkan morfologi tanaman aglaonema untuk mengetahui karakteristik dari masing-masing tanaman dan mempelajari hubungan kekerabatan genetik antar tanaman aglaonema. Bahan penelitian yaitu 25 tanaman aglaonema antara lain : Pride of Sumatra, Ruby Super Pink, Ruby Kura, Suksom Jaipong, Asri, Nancy,Shinta, Legacy, Tiara, Legacy Putih, Tiara Putih, Kochin Brown, Sexy Pink, Ayu Green, Anjamani, Sartika, Charlie Brown, Snowwhite, Donacarmen, Big Leaf, Krisna Golden, Bidadari, Siam Aurora, Queen of Siam, dan Kanza. Hasil dari karakterisasi morfologi menghasilkan dendrogram dengan koefisien kemiripan sebesar 0,82 terbagi menjadi 2 klaster dan berdasarkan analisis komponen utama (PCA) tanaman aglaonema dapat diklasifikasikan menjadi 3 macam kombinasi warna tunggal, kombinasi dua warna dan kombinasi tiga warna.
Pengembangan Formula dan Pembuatan Controlled Release Fertilizer (CRF) untuk Bawang Merah
Authors: Noor Ilhamsyah , Arfiana Arfiana , Finalis Era Restu , Tjahjono Endro Wahju , Suratno Hadi , Hamzah Hamzah , Mulyono Agus , Nuraini Listiyo Dyah , Jaim Jaim , Suradi Suradi , Saputra Hens
Published: September 2022

Bawang merah merupakan salah satu komoditas sayuran unggulan yang memiliki nilai ekonomi yang tinggi. Data produksi bawang merah di Indonesia menunjukkan bahwa produktivitas hasil bawang merah tersebut masih dapat ditingkatkan. Pemupukan merupakan salah satu alternatif solusi untuk meningkatkan produktivitas tanaman. Efisiensi pemupukan harus ditingkatkan mengingat rendahnya efisiensi penggunaan pupuk buatan yang disebabkan oleh banyak faktor, antara lain karena kehilangan bahan aktif (nutrient) melalui proses degradasi mikrobial, volatilisasi ataupun tercuci oleh aliran permukaan. Salah satu solusi untuk meningkatkan efisiensi penggunaan pupuk adalah CRF. Controlled Release Fertilizer (CRF) merupakan jenis pupuk dengan mekanisme pelepasan unsur hara secara berkala mendekati pola penyerapan oleh tanaman sehingga unsur hara yang terkandung dalam pupuk tidak terbawa oleh air. CRF yang dikembangkan merupakan formula pupuk lengkap untuk bawang merah yang meliputi makro nutrient (N, P, K), makro sekunder (Sulfur, Magnesium, Kalsium), serta mikro nutrient (Zinc, Cuprum, dan Asam humat). Berdasarkan rekomendasi badan litbang dan peraturan-peraturan terkait formula pupuk untuk bawang merah, dihasilkan 2 buah formula yang disesuaikan dengan kebutuhan tanaman bawang merah. Dihasilkan 2 buah prototype pupuk untuk tanaman bawang merah (NPK CRF 14-7-9-6-4-2 dan NPK CRF 16-7-10-6-2). Kedua pupuk tersebut di coating dengan menggunakan asam humat, dari hasil coating dengan menggunakan asam humat, nilai crushing strength dari granul pupuk meningkat 1,5x lipat dibandingkan sebelum di coating. Selain sifat asam humat yang dapat menghambat pelepasan N, peningkatan crushing strength juga dapat memperlambat proses degradasi granul pupuk.
Representación mexicana en Denver. Conversación con la Mtra. Inci Caballero Donis
Authors: Moncada Laura
Published: September 2022

Emprendedora y entusiasta por la vida la Mtra. Caballero adquirió la mayor parte de su experiencia a través del trabajo con organizaciones sin fines de lucro, donde ha tenido la oportunidad de trabajar con niñas, niños, y mujeres víctimas de violencia doméstica. A través de actividades especializadas en la psicoeducación, terapia de arte, terapia recreacional fundamentados en entrevistas y evaluaciones a ofensores de violencia doméstica, ha podido apoyar a la comunidad hispana y colaborar con el Consulado Mexicano en Denver, para mejorar la atención y la ayuda a dicha comunidad.
La conectividad un factor clave para la competitividad económica. El caso de la región del Bajío, México
Authors: Zúñiga Arrieta Verónica Del Rocío , Suárez Paniagua Susana
Published: September 2022

Objetivo: analizar el papel quedesempeña la conectividad en la Región del Bajío, México para el logro de su competitividad económica, establecer si es un factor que le otorga una ventaja competitiva absoluta.   Diseño Metodológico: se realizó una revisión de los planteamientos teóricos sobre globalización, competitividad y conectividad, particularmente de los que establecen una relación entre conectividad y competitividad, se recopiló información sobre la disposición de la conectividad con la que cuenta la región, así como sobre algunas variables económicas referidas a la exportación (subsectores de mayor volumen de exportación, personal ocupado, empresas y su aportación PIB). Luego se elaboró un índice de conectividad de la región con base en la obtención del índice de conectividad terrestre, del índice de conectividad de vías áreas y del índice de conectividad marítima y por último se calculó el coeficiente de correlación y el coeficiente de Pearson entre la conectividad y las variables económicas.  Resultados: se encontró que existe una relación entre el índice de conectividad con la competitividad de la región -medida a través de las exportaciones-, por medio de la obtención del coeficiente de correlación y el coeficiente de Pearson entre estas variables, los cuales indican una correlación positiva, pero no robusta en la región.  Limitaciones de la investigación: la falta de información documental referente a las vías de comunicación por parte de fuentes oficiales.  Hallazgos: se encontró que la conectividad con la que cuenta la región no es igual en todos los estados que la integran, y ello propicia que las empresas se concentren en aquellos lugares donde existe mayor cobertura y accesibilidad de infraestructura física, por lo que si bien la conectividad constituye una ventaja competitiva absoluta, se advierte que no todos los territorios cuentan en la misma medida con esta ventaja.
Sistema adhesivo a base de resina en ortodoncia: una perspectiva
Authors: Chanes-Cuevas Osmar Alejandro
Published: September 2022

La adhesión directa fue descrita inicialmente por Newman en 1965, se inició utilizando resina epóxica adherida a brackets de plástico donde existían inquietudes por la inmersión de los brackets en saliva que pudiera deteriorar el sistema adhesivo. Al pasar los años, los sistemas adhesivos disponibles han sido modificados con variedad de rellenos, vehículos y componentes que permiten una gran variedad de sistemas y técnicas para buscar una que se adapte de la mejor forma al método de trabajo de cada profesional.1
Partial Use of Bakelite Powder in Concrete Structures as an Alternative to Natural Sand
Authors: Gupta Gyandeep , Rajneesh Mr.
Published: September 2022

Abstract: As we know that construction is a very important and basic part of development. In todays scenario every developed or developing are more focused in developing their infrastructure , which should be aesthetically beautiful, durable ,last but but not least Economical also. Specially in India which is a developing nation is going through lots of infrastructure development needs a durable and also economical construction materials specially sand, cement and concrete.so in this project more focus is on making the construction more cheaper and affordable to all the classes of society.so in this we have used Bakelite powder as adultrent in concrete to check its effect on its durability and effectiveness.as Bakelite is a thermoplastic material. It can not be reused to manufacture a modern products, so therefore it is either dumped or burnt both are which are harmful to the environment. As we have seen that influence of water on Bakelite best determined by oxidisabilty of the material and presence of phenol in water, so as if Bakelite powder is dumped in water it causes very serious sewage problem, so using Bakelite partial in place of sand may be a another way of treating problem of both construction and disposal of Bakelite. We have encountered problems in digging sand illegally like dregeing the sand from river beds and lakes which causing the thinning of rivers and lakes, this also leads to various environmental problems .
The Development of CEFR-Based Nahwu And Shorof Learning Evaluation in MA An-Nur Jagasatru Cirebon
Authors: Zainal Arifin Ahmad  , Irfan Hania  , Faizmailiatus Sofa  , Sri Utami  , Putri Nurinadia  , Yusril Muna Muhammad
Published: September 2022

This study aimed to determine the implementation and development of CEFR-based nahwu and shorof learning evaluations at MA An-Nur Jagasatru Cirebon. The research methodology used is the research and development method. In the development of this research, we used the Rowntree model, which was consisted of three stages, namely the planning stage, the development stage, and the evaluation stage. The trial phase began with the validation of material experts and linguists. Then, after being revised, the product was tested on class X students, namely 8 students for testing prototype 1 and 21 students for testing prototype 2. The results showed that the average score of material experts was 85%, which meant the product was considered very good, and linguists 88%, which meant the product was considered very good. Then at the testing stage of prototype 1, an average score of 64.37, which meant the product was considered quite good, and at the testing stage of prototype 2, an average score of 74.71, which meant it was considered very good. Based on interviews with teachers, they obtained very good results. Based on the results of the study, it can be concluded that the evaluation of nahwu and shorof learning based on CEFR is feasible and effective as an evaluation tool in nahwu and shorof learning, especially in MA An-Nur Jagasatru Cirebon.
Understanding the HRM systems double contribution to radical and incremental innovation in SMEs: A configurational approach
Authors:   ADVANCE/CSG, Instituto Superior de Economia e Gestão, Universidade de Lisboa, Portugal, Curado Carla , Gonçalves Tiago ,   ADVANCE/CSG, Instituto Superior de Economia e Gestão, Universidade de Lisboa, Portugal, Brito João Costa ,   Instituto Superior de Economia e Gestão, Universidade de Lisboa, Portugal
Published: September 2022

Aim/purpose – In this paper, we explore the contribution of Human Resource Manage- ment Systems (HRMS) to innovation in SMEs. We consider two HRMS with different orientations: Commitment HRMS (focusing on long-term career development to in- crease employees’ creativity) and Collaboration HRMS (focusing on the use of external human capital to achieve innovation). We believe that SMEs’ radical and incremental innovation follow different paths from a configurational perspective. We want to under- stand how the two HRMS influence radical and incremental innovation, consequently, we explore the contributions of Commitment HRMS and Collaboration HRMS. Design/methodology/approach – We apply a set-theoretic method, an analytic quanti- tative and qualitative technique to approach data – fuzzy-set Qualitative Comparative Analysis (fsQCA) – to test our models. We use a sample of 377 Portuguese SMEs from across industries. Findings – Results show there are two pathways that lead SMEs to high levels of incre- mental innovation and three alternative paths that originate high levels of radical innova- tion. By contrast, there are ways that lead to lower levels of incremental (two options) and radical innovation (three options). Research implications/limitations – We provide propositions for theory development on the contribution of HRMS to innovation. Managerial contributions regard the several options provided to SME managers in search of innovation. Limitations regard the lack of generalization power of results due to the cross-sectional nature of the work. However, the research design is replicable without restrictions. Originality/value/contribution – We suggest that SMEs’ radical and incremental inno- vation follow different paths from a configurational perspective. With this study, we contribute to showing the diversity of ways to reach higher innovation levels at SMEs, so that managers know the alternatives they have at their disposal. Additionally, we reveal the ways that lead to lower innovation levels at SMEs, so we alert managers to the undesired pathways they should be cautious about. Keywords: Human Resources Management Systems, incremental innovation, radical innovation, SME, fsQCA. JEL Classification: M12, O15, O31.
Gestión educativa definida para desarrollar la capacitación lingüística MEP-CONARE entre los años 2015-2018
Authors: Arley-Fonseca Margoth , Brizuela-Gutiérrez Tobías
Published: September 2022

En este artículo se pretende determinar las percepciones del personal docente de inglés de distintas Direccionales Regionales del Ministerio de Educación Pública (MEP) y representantes de la Comisión Interuniversitaria del Consejo Nacional de Rectores (CONARE) acerca de la gestión educativa definida para desarrollar las capacitaciones lingüísticas MEP-CONARE entre los años 2015-2018. El método de indagación se basa en los principios del enfoque mixto, con la aplicación de cuestionarios al personal docente de inglés participante y entrevistas a las personas representantes de la Comisión Interuniversitaria del CONARE. Los datos recopilados fueron verificados con el desarrollo de un análisis del documento legal del convenio firmado por la ministra de Educación y el presidente del CONARE. Dentro de los principales hallazgos se identificó una debilidad en la divulgación de las metas y propósitos del convenio; empero, se aseguró la consecución de los objetivos propuestos mediante la constante evaluación de las actividades. Se concluye que, para asegurar el éxito de un convenio de esta índole, es necesario ofrecer un espacio de diálogo para explicar los objetivos lingüísticos de la capacitación y las metas del convenio a nivel país, con la aplicación de una comunicación organizacional estratégica que permita asegurar un compromiso real por parte del personal docente.
Editorial: New trends in corporate law and governance — Future expectations
Authors: Andreadakis Stelios
Published: September 2022

This new issue contains five contributions that deal with both theoretical and practical aspects related to corporate law and corporate governance. The authors have put together five extremely interesting pieces of work, using a variety of doctrinal and empirical research methodologies and adopting an interdisciplinary perspective. The topics range from corporate governance regulation to due diligence and from corporate entrepreneurship to foreign direct investment, with case studies focusing on Greece, Finland, Sri Lanka, and the Philippines. The research findings confirm the richness that characterises the international corporate landscape and the contemporary character of such intellectual inquiries.
Impact of Coronavirus disease 2019 (COVID-19) vaccination on menstrual bleeding quantity: an observational cohort study
Authors: Darney Blair , Boniface Emily , Lamsweerde Agathe Van , Han Leo , Matteson Kristen , Cameron Sharon , Male Victoria , Acuna Juan , Benhar Eleonora , Pearson Jack , Edelmann Alison
Published: September 2022

Objective Assess whether coronavirus disease 2019 (COVID-19) vaccination
impacts menstrual bleeding quantity. Design Retrospective cohort Setting
Five global regions Populations Vaccinated and unvaccinated regularly
cycling individuals using the digital fertility-awareness application
“Natural Cycles”. Methods We used prospectively collected menstrual
cycle data and multivariable longitudinal Poisson GEE models,
multivariable multinomial logistic regression models, and calculated the
adjusted difference between vaccination groups. All regression models
were adjusted for confounders. Outcome measures Mean number of heavy
bleeding days (fewer, no change, more) and changes in bleeding quantity
(less, no change, more) at three time points (first dose, second dose,
and post-exposure menses). Results We included 9,555 individuals (7,401
vaccinated, 2,154 unvaccinated). About 2/3 of individuals reported no
change in the number of heavy bleeding days regardless of vaccination
status. After adjusting for confounders, there were no significant
differences in the number of heavy bleeding days by vaccination status.
A larger proportion of vaccinated individuals experienced an increase in
total bleeding quantity (34.5% unvaccinated, 38.4% vaccinated; 4.0%
[0.7, 7.2%] adjusted difference). This translates to an estimated
40 additional people per 1,000 normally cycling individuals who
experience more total bleeding quantity following the first vaccine dose
due to vaccination. Differences resolved in the cycle post-exposure.
Conclusion A small increase in the probability of more total bleeding
quantity occurs following the first COVID-19 vaccine dose which resolved
the cycle post-vaccination cycle. Total number of heavy bleeding days
did not differ by vaccination status. Our findings can reassure the
public that any changes are small and transie
The efficacy of topical imiquimod in high-grade cervical intraepithelial neoplasia: a systematic review and meta-analysis
Authors: Sande Anna van de , Kengsakul Malika , Koeneman Margot , Jozwiak Marta , Gerestein Kees , Kruse Arnold-Jan , Esch Edith M.G. van , Steenwijk Peggy de Vos van , Muntinga Caroline L.P. , Bramer Wichor M. , Kemenade Folkert van , Beekhuizen Heleen van
Published: September 2022

Background Surgical treatment for high-grade cervical intraepithelial
neoplasia (CIN) may affect future fertility and pregnancy outcomes,
therefore alternative therapies are desirable. Objectives To determine
the efficacy of topical imiquimod in treatment of high-grade CIN
(defined as regression CIN 1 or less), and to determine the clearance
rate of high-risk human papillomavirus (hr-HPV), compared to surgical
treatment and placebo. Search strategy Cohort studies and trials up to
July 2022 were searched with the terms imiquimod, cervical dysplasia,
and HPV. Selection criteria Studies evaluating the efficacy of imiquimod
in CIN lesions. Data collection and analysis The study followed the
PRISMA checklist. Meta-analysis was conducted to determine the efficacy
of imiquimod treatment. Main results Five studies involving 463 women
with high-grade CIN were included. Imiquimod was associated with
histological regression to CIN1 or less in 55% of cases versus 29% for
placebo, and 93% for surgical treatment. Imiquimod-treated women had a
greater odds ratio of histological regression to CIN1 or less than
placebo-treated women (ORs 4.17, 95% CI 2.03-8.54). In comparison to
imiquimod, surgical treatment had an odds ratio of 14.81 (95% CI
6.59-33.27) for histological regression to CIN1 or less. The hr-HPV
clearance rate was 53.4% after imiquimod treatment and 66% after
surgical treatment (ORs 1.53, 95% CI 0.62-23.77). Conclusions:
Histological regression is higher in imiquimod treatment than placebo.
Surgical treatment, which is currently the golden standard, shows a
higher regression rate than imiquimod. Future studies should focus on
patient selection and further development of alternative treatments.
Review of Delivering Foreign Substances into Live Cells by Microinjection: Key Technologies and Applications
Authors: Chen 浩 , Chen Hao , Wang Li , Su Weiguang , He Wende , Wang Anqun , Li Anqing , Liu Pengbo , Zhao Xiangyu , Xu Chonghai
Published: September 2022

A key operation in modern genetic engineering is to deliver foreign
substances (like modified subcellular organelles, DNA molecules, and
drugs) into live cells. Compared with the traditional methods like
polyethyleneimine (PEI), cationic liposomes, viral vectors,
electroporation, gene gun, etc., microinjection is a rising star due to
the advantages of excellent safety, full controllability, high
precision, and high survival rate. This review focuses on the recent
development of microinjection technology and its applications in animal
cells, yeast, fungal cells, and plant cells. Guidelines are provided for
selecting the most appropriate microinjection method and system
configuration for different application scenarios. When the outer
membrane of the host cell is difficult to break, the piezo-driven
penetrator could assist the penetration significantly and causes less
damage to the host cell during microinjection process. The major
existing challenges in microinjection are also analyzed. Overall,
microinjection could become a standard technology for modern genetic
engineering and microbiology.
Adapting Rice to Atmospheric Carbon Dioxide: A GMO approach to yield enhancement and nutritional integrity.
Authors: Wang Dongming , Ziska Lewis , Xu Xi , Tao Ye , Zhang Jishuang , Liu Gang , Cai Chuang , Song Lian , Zhu Chunwu
Published: September 2022

There is extensive evidence that rising atmospheric carbon dioxide
concentration, [CO ] can stimulate rice yields.
However, such increases are associated with a ubiquitous decline in
nutrition, including protein, iron (Fe) and zinc (Zn). To determine the
basis for these declines, we used gmo rice lines to test and compare the
quantitative and qualitative metrics relative to their non-gmo
counterparts at elevated [CO ] in situ. The
gmo / non-gmo paired comparisons were associated with three phenological
/ metabolomic characteristics: (1) increased stomatal conductance, (2)
an enlarged root system, and (3) enhanced nitrate absorption. All gmo
lines showed a significantly higher percent stimulation of seed yield
relative to their paired non-gmo cultivar at elevated [CO
]. Qualitatively, relative to non-gmos, leaf nitrogen
and brown rice protein were not significantly reduced and for (1) and
(2) the gmo lines showed no decline in Fe and Zn with elevated [CO
]. These findings do not, de facto, represent
a gmo “solution” to [CO ] induced nutritional
decay; however they provide the first evidence that gmo lines related to
specific traits could be fundamental in selecting qualitative and
quantitative responses of global rice to maintain yield and nutritional
integrity in response to projected increases in atmospheric [CO
].
THE VALUE OF ECHOCARDIOGRAPHY IN PREDICTING PULMONARY THROMBOEMBOLIC DISEASE
Authors: Grigorov Vladimir , Esser Jan Daniel , Grigorov Mladen , Grigorov Evgeni , Nocheva Hristina
Published: September 2022

This is a 200 patient retrospective single-centre study focused on
evaluating the contribution of echocardiography (Echo) findings as an
initial screening tool in selecting intensive care unit (ICU) patients
with suspected pulmonary embolism (PE) for further diagnostic evaluation
with ventilation/perfusion (V/Q) scintigraphy. A total of 200 patients
with suspected PE were referred for a V/Q scan. Of these 24 had Еcho
findings of a dilated right ventricle (RV). 8 of these 24 patients
(33%) had a positive V/Q scan for PE. Seven of those 8 patients (88%)
had large pulmonary emboli. Of the remaining 176 patients (without
dilated RV) the V/Q scan was positive for pulmonary emboli in 39 cases
(22%). If evaluating only the patients positive for pulmonary emboli on
V/Q scan (47 patients), 8 of them (17%) had a dilated RV, and 39 (83%)
did not have a dilated RV. Thus, we found Еcho mainly contributed to
identifying patients with life threatening large pulmonary
thrombo-embolic disease. In contrast to the above, echocardiography was
non-contributory in the presence of small PE. This was in congruence
with the existing literature.
Posterolateral or direct lateral approach for cemented hemiarthroplasty after femoral neck fracture (APOLLO): protocol for a multicenter randomized controlled trial with economic evaluation and natural experiment alongside
Authors: Tol Maria C J M , Willigenburg Nienke W , Willems Hanna C , Gosens Taco , Rasker Ariena , Heetveld Martin J , Schotanus Martijn G M , Van Dongen Johanna M , Eggen Bart , Kormos Mate , Van der Pas Stéphanie L , Van der Vaart Aad W , Poolman Rudolf W , APOLLO research group On behalf of the
Published: September 2022

Background and purpose: The posterolateral and direct lateral surgical approach are the 2 most common surgical approaches for performing a hemiarthroplasty in patients with a hip fracture. It is unknown which surgical approach is preferable in terms of (cost-)effectiveness and quality of life.Methods and analysis: We designed a multicenter randomized controlled trial (RCT) with an economic evaluation and a natural experiment (NE) alongside. We will include 555 patients ≥ 18 years with an acute femoral neck fracture. The primary outcome is patient-reported health-related quality of life assessed with the EQ-5D-5L. Secondary outcomes include healthcare costs, complications, mortality, and balance (including fear of falling, actual falls, and injuries due to falling). An economic evaluation will be performed for quality adjusted life years (QALYs). We will use variable block randomization stratified for hospital. For continuous outcomes, we will use linear mixed-model analysis. Dichotomous secondary outcome measures will be analyzed using chi-square statistics and logistic regression models. Primary analyses are based on the intention-to-treat principle. Additional as treated analyses will be performed to evaluate the effect of protocol deviations.Study summary: (i) Largest RCT addressing the health-related patient outcome of the main surgical approaches of hemiarthroplasty. (ii) Focus on outcomes that are important for the patient. (iii) Pragmatic and inclusive RCT with few exclusion criteria, e.g., patients with dementia can participate. (iv) Natural experiment alongside to amplify the generalizability. (v) The first study conducting a costutility analysis comparing both surgical approaches.
Primary Adrenal Insufficiency Due to Extra pulmonary Tuberculosis in a Patient without HIV: A Case Report
Authors: Amilcar Rivero Rejon
Published: September 2022

Adrenal or adrenal insufficiency deals with a special pathology that has multiple etiologies and is characterized by deficiency in the secretion of steroids at this level. Around 80% of these etiologies are of autoimmune origin, however, the rest are due to infectious causes, infiltrative, genetic, vascular, neoplastic and even pharmacological diseases. The diagnosis requires high suspicion and treatment dependent on the cause. It is a life-threatening pathology that has a very broad etiology, and it does not always present as a frank adrenal crisis; therefore, high diagnostic suspicion is important.
Possible Role of Vitamin D3 in the Prevention of COVID-19 Infection and Mortality
Authors: Ataee Ramin
Published: September 2022

Despite many efforts around the world to control the outbreak of COVID- 19 virus, this issue has become a pandemic. According to the latest research on the global spread of COVID- 19, researchers have found that adequate vitamin D3 increases resistance to viral infections, reduces the severity of symptoms of the disease, and ultimately mortality rate. However, the results are still contradictory. There are receptors in the human body called ACE2. The COVID- 19 virus can enter the body by binding to these receptors, and the symptoms of the disease develop gradually. Meanwhile, vitamin D3 can attach to these receptors and prevent the corona virus from attaching to the body’s organs. Thus, people who have lower levels of vitamin D3 absorbed during this epidemic should take vitamin D supplements to maintain an optimal level of 25 (OH) D in the blood. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations. There is insufficient evidence between level of vitamin D3 intake and mortality rate of COVID-19 in patients. This review summarizes some of the latest findings about the role of vitamin D3 in COVID-19 infections, severity, and mortality.
Effect of L-Tocopherol on Morphological Reformations of Rat’s Pineal Gland under the Long-Term Impact of Heavy Metal Salts
Authors: Hryntsova NB
Published: September 2022

The article presents the results of the study on morphological rearrangements of structural changes in the rat pineal gland under the influence of heavy metal salts and correction with L-tocopherol during 60 days. General morphological and statistical research methods were used (histological, morphometric, immunohistochemical and statistical methods). The article presents the results of the study on morphological rearrangements of structural changes in the rat pineal gland under the influence of heavy metal salts and correction with L-tocopherol during 60 days. General morphological and statistical research methods were used (histological, morphometric and statistic methods). The protective effect of L-tocopherol caused a number of compensatory-adaptive processes in the pineal gland aimed at neutralizing the effects of stressors on the organ. Under the influence of α-tocopherol acetate, the tension on the part of the synthetic apparatus of pinealocytes decreases compared to the indicators of animals that did not use the corrector drug. The 60-days protective period of L-tocopherol is insufficient to completely neutralize the heavy metals impact on the organ: the glial response activated, the vascular area increased, vascular wall’s permeability impaired, edema was formed and the connective tissue component grew, indicating dysfunctional reorganization of the gland’s secretory activity. The above morphological changes in the pineal gland’s structural components negatively affect the processes of hormones evacuation into the blood, the course of the general adaptation syndrome and homeostasis restoration in the organ.
Spread of bacterial wilt disease on potato in three villages in Silimakuta District, Simalungun, North Sumatra, Indonesia
Authors: Rahmadhani Nahrisa , Pinem Mukhtar Iskandar , Safni Irda
Published: September 2022

Bacterial wilt disease caused by Ralstonia syzygii subsp. indonesiensis is an important disease in potatoes. This disease is a soil-borne pathogen that is difficult to control and becomes an obstacle in potato production. This study aimed to determine the distribution of bacterial wilt disease in potatoes caused by R. syzygii subsp indonesiensis in three villages in Silimakuta District, Simalungun Regency, North Sumatra. This research was exploratory research that was conducted using a survey method by calculating the incidence of disease in potatoes in 9 locations from three villages. The results showed that the intensity of bacterial wilt occurred with different percentages of disease incidence. The highest disease incidence of 100% was in Sibangun Meriah Village Location 2 and the lowest disease incidence of 22,5% was in Saribu Dolok Village Location 1.
Azot Gazı Atmosferinde Isıl İşlem Uygulanmış Kavak Odununun Fiziksel Özellikleri
Authors: ORHAN Hasan , BAL Bekir Cihad
Published: September 2022

Odunun bazı özelliklerini iyileştirmek amacıyla, farklı odun modifikasyon yöntemleri geliştirilmiştir. Odunun, 180-220oC sıcaklık ile muamele edilerek uygulanan ısıl işlem yöntemi bu yöntemlerden birisidir. Günümüzde, farklı işlem basamaklarından oluşan ve farklı ısı taşıyıcı araçların kullanıldığı bir çok ısıl işlem metodu geliştirilmiştir. Isıl işlemin odunun teknolojik özelliklerinde meydana getirdiği değişiklikler üzerine birçok faktör etkili olmaktadır. Isı transfer aracı bu faktörlerden birisidir. Bu araştırmada, ısı taşıyıcı olarak azot gazı ve materyal olarak kavak odunu kullanılmıştır. Bu çalışmanın amacı, azot gazı atmosferinde ve normal atmosferde yapılan ısıl işlemin, odununun fiziksel özellikleri üzerine etkisini belirlemektir. Isıl işlem sonrası, kavak odununun yoğunluk, denge rutubet yüzdesi, teğet, radyal, boyuna ve hacmen genişleme yüzdeleri ve genişleme anizotropisi gibi fiziksel özellikler belirlenmiştir. Elde edilen bulgulara göre; hem normal atmosferde ve hem de azot gazı atmosferinde yapılan ısıl işlemin, kavak odununun fiziksel özellikleri üzerine istatistiksel olarak önemli derecede etkili olduğu belirlenmiştir.
Islandness in human rights, human rights in islandness: Missing voices
Authors: Tsampi Aikaterini
Published: September 2022

Island Studies literature has rarely engaged with human rights law to scrutinise how the development of human rights standards and/or their (in)efficient implementation on islands contour the lives of islanders and islandness itself. Along similar lines, human rights research and practice do not systematically take into account islandness and Island Studies research. The present article explores the mutual reticence between human rights law and Island Studies, suggesting, though, that both fields can offer each other important opportunities for development. It advocates, in particular, that it is high time for a cohesive human rights and islands approach which is based on the human rights-based approach of islandness and the islandness-based approach in human rights. A potential cross-fertilisation between human rights law and Island Studies can be very promising not only for the advancement of the respective fields from a scholarly point of view, but also for a more efficient understanding of islandness and protection of human rights in practice.
Visitadoras de higiene en la atención materno infantil. Ciudad de La Plata, 1930-1940
Authors: Gavrila Canela Constanza
Published: September 2022

El objetivo del siguiente trabajo es presentar los cambios y persistencias producidos en la atención materna infantil desde la profesionalización de los trabajos de asistencia social durante 1930 y 1940 en la ciudad de La Plata y las tensiones que esto provocó con la Sociedad de Beneficencia. A través de una metodología cualitativa se analizan distintas fuentes que dan cuenta del aporte realizado por las visitadoras de higiene para el abordaje científico de la maternidad e infancia, a fin de presentar a modo de conclusión las particularidades que asumió la feminización de las tareas de asistencia en dicha coyuntura.
Queirolo, Graciela (2020). Mujeres que trabajan. Labores femeninas, Estado y sindicatos. Buenos Aires, 1910-1960. Buenos Aires, Editorial de la Universidad Nacional de Mar del Plata, Grupo Editor Universitario, 179 págs.
Authors: Ramírez Natalia
Published: September 2022

Revisión del libro Mujeres que trabajan. Labores femeninas, Estado y sindicatos. Buenos Aires, 1910-1960 por G. Queirolo
Optimization of Parameters of a Vibroconveyor System for Infrared Drying of Soy
Authors: Malkina Vira , Kiurchev Sergey , Hutsol Taras , Verkholantseva Valentуna , Kiurcheva Lyidmila , Miroshnichenko Mykola , Biliuk Mykola , Pidlisnyj Vitaliy , Gürgülü Hatice , Kowalczyk Zbigniew
Published: September 2022

This paper proposes a method to determine the optimal parameters for the drying of soybean using a kinematic vibration dryer. Among the main parameters of the investigated vibroconveyor are heat and mass transfer, physical and mechanical. The paper presents a mathematical model of the dependence of parameters of the soybean drying process of soybean built based on experimental data obtained by organizing an effective experiment plan with a sufficiently large number of factor levels. To determine the rational parameters for drying soybean, it is important to build the most accurate and adequate mathematical model, which will determine the most accurate values of the required parameters. For this purpose, it is recommended to conduct an experiment with as many levels of factors as possible. The article proposes an experiment established on a dedicated balanced orthogonal plan, which is optimal according to the D-efficiency criterion. Based on the experimental data, an adequate mathematical model of the dependence of the drying characteristics of soybean (moisture of the processed material (%), temperature inside the product layer (°С) on the parameters – vibration amplitude (mm), distance from the conveyor surface (mm), radiation power (Wt), weight (g·min−1). Following the analysis of the constructed mathematical model, optimal parameters of the developed vibroconveyor infrared dryer were substantiated. The main characteristics of the vibroconveryor mechanism of interoperational transportation of bulk products in the working area were also determined, and a technical and economic analysis of the developed oscillatory system was conducted.