bluuebunny/crossref_metadata_2025 huggingface dataset:
Microtube Array Membrane (MTAM)-Based Encapsulated Cell Therapy for Cancer Treatment
Authors: Chew Chee Ho , Lee Chih-Wei , Huang Wan-Ting , Cheng Li-Wei , Chen Amanda , Cheng Tsai-Mu , Liu Yen-Lin , Chen Chien-Chung
Published: April 2020

The treatment of cancer has evolved significantly in recent years with a strong focus on immunotherapy. Encapsulated Cell Therapy (ECT) for immunotherapy-based anti-cancer treatment is a unique niche within this landscape, where molecules such as signaling factors and antibodies produced from cells are encapsulated within a vehicle, with a host amount of benefits in terms of treatment efficacy and reduced side effects. However, traditional ECTs generally lie in two extremes; either a macro scale vehicle is utilized, resulting in a retrievable system but with limited diffusion and surface area, or a micro scale vehicle is utilized, resulting in a system that has excellent diffusion and surface area but is unretrievable in the event of side effects occurring, which greatly compromises the biosafety of patients. In this study we adapted our patented and novel electrospun Polysulfone (PSF) Microtube Array Membranes (MTAMs) as a ‘middle’ approach to the above dilemma, which possess excellent diffusion and surface area while being retrievable. Hybridoma cells were encapsulated within the PSF MTAMs, where they produced CEACAM6 antibodies to be used in the suppression of cancer cell line A549, MDA-MB-468 and PC 3 (control). In vitro and in vivo studies revealed excellent cell viability of hybridoma cells with continuous secretion of CEACAM6 antibodies which suppressed the MDA-MB-468 throughout the entire 21 days of experiment. Such outcome suggested that the PSF MTAMs were not only an excellent three-dimensional (3D) cell culture substrate but potentially also an excellent vehicle for the application in ECT systems. Future research needs to include a long term in vivo >6 months study before it can be used in clinical applications.
Mechanical and Microstructural Characterization of TIG Welded Dissimilar Joints between 304L Austenitic Stainless Steel and Incoloy 800HT Nickel Alloy
Authors: Rogalski Grzegorz , Świerczyńska Aleksandra , Landowski Michał , Fydrych Dariusz
Published: April 2020

In this article, the mechanical properties and microstructure of 304L austenitic stainless steel/Incoloy 800HT nickel alloy dissimilar welded joints are investigated. The joints were made of 21.3 mm × 7.47 mm tubes using the TIG process with the use of S Ni 6082 nickel filler metal. No welding imperfections were found and high strength properties of joints were obtained, meeting the assumed acceptance criteria of the product’s standards. The tensile strength of the welded joints was higher than for the joined materials (Incoloy 800HT). Macro- and microscopic metallographic tests revealed the correct morphology of the joints and the appropriate structures in their critical zones. However, differences were found in the morphologies of the zones between the weld and the base materials. In fusion boundary from the side of the Incoloy 800HT alloy, no clear outline of the fusion line was observed (type A fusion boundary), while increased grain size and an epitaxial structure were observed. In turn, in the zone: weld–304L steel, a distinct fusion line was observed with areas with an increased amount of high-temperature δ ferrite (type B fusion boundary). No precipitates were found that could reduce the resistance of the joints to intergranular corrosion. A hardness decrease (approximately 30 HV0.1) in the transition zone: austenitic steel–weld and an increase of hardness (approximately 10 HV0.1) on the opposite side of the welded joint were observed.
Antibiofilm Activity of a Trichoderma Metabolite against Xanthomonas campestris pv. campestris, Alone and in Association with a Phage
Authors: Papaianni Marina , Ricciardelli Annarita , Fulgione Andrea , d’Errico Giada , Zoina Astolfo , Lorito Matteo , Woo Sheridan L. , Vinale Francesco , Capparelli Rosanna
Published: April 2020

Biofilm protects bacteria against the host’s immune system and adverse environmental conditions. Several studies highlight the efficacy of lytic phages in the prevention and eradication of bacterial biofilms. In this study, the lytic activity of Xccφ1 (Xanthomonas campestris pv. campestris-specific phage) was evaluated in combination with 6-pentyl-α-pyrone (a secondary metabolite produced by Trichoderma atroviride P1) and the mineral hydroxyapatite. Then, the antibiofilm activity of this interaction, called a φHA6PP complex, was investigated using confocal laser microscopy under static and dynamic conditions. Additionally, the mechanism used by the complex to modulate the genes (rpf, gumB, clp and manA) involved in the biofilm formation and stability was also studied. Our results demonstrated that Xccφ1, alone or in combination with 6PP and HA, interfered with the gene pathways involved in the formation of biofilm. This approach can be used as a model for other biofilm-producing bacteria.
Preparation of Zirconium Phosphate Nanomaterials and Their Applications as Inorganic Supports for the Oxygen Evolution Reaction
Authors: Ramos-Garcés Mario V. , Colón Jorge L.
Published: April 2020

Zirconium phosphate (ZrP) nanomaterials have been studied extensively ever since the preparation of the first crystalline form was reported in 1964. ZrP and its derivatives, because of their versatility, have found applications in several fields. Herein, we provide an overview of some advancements made in the preparation of ZrP nanomaterials, including exfoliation and morphology control of the nanoparticles. We also provide an overview of the advancements made with ZrP as an inorganic support for the electrocatalysis of the oxygen evolution reaction (OER). Emphasis is made on how the preparation of the ZrP electrocatalysts affects the activity of the OER.
Incorporating Aminated Nanodiamonds to Improve the Mechanical Properties of 3D-Printed Resin-Based Biomedical Appliances
Authors: Mangal Utkarsh , Seo Ji-Young , Yu Jaehun , Kwon Jae-Sung , Choi Sung-Hwan
Published: April 2020

The creation of clinically patient-specific 3D-printed biomedical appliances that can withstand the physical stresses of the complex biological environment is an important objective. To that end, this study aimed to evaluate the efficacy of aminated nanodiamonds (A-NDs) as nanofillers in biological-grade acrylate-based 3D-printed materials. Solution-based mixing was used to incorporate 0.1 wt% purified nanodiamond (NDs) and A-NDs into UV-polymerized poly(methyl methacrylate) (PMMA). The ND and A-ND nanocomposites showed significantly lower water contact angles (p < 0.001) and solubilities (p < 0.05) compared to those of the control. Both nanocomposites showed markedly improved mechanical properties, with the A-ND-containing nanocomposite showing a statistically significant increase in the flexural strength (p < 0.001), elastic modulus (p < 0.01), and impact strength (p < 0.001) compared to the control and ND-containing groups. The Vickers hardness and wear-resistance values of the A-ND-incorporated material were significantly higher (p < 0.001) than those of the control and were comparable to the values observed for the ND-containing group. In addition, trueness analysis was used to verify that 3D-printed orthodontic brackets prepared with the A-ND- and ND-nanocomposites exhibited no significant differences in accuracy. Hence, we conclude that the successful incorporation of 0.1 wt% A-ND in UV-polymerized PMMA resin significantly improves the mechanical properties of the resin for the additive manufacturing of precisive 3D-printed biomedical appliances.
The Impact of Aerobic Exercise and Badminton on HDL Cholesterol Levels in Taiwanese Adults
Authors: Nassef Yasser , Lee Kuan-Jung , Nfor Oswald Ndi , Tantoh Disline Manli , Chou Ming-Chih , Liaw Yung-Po
Published: April 2020

Elevated levels of high-density lipoprotein cholesterol (HDL-C) have been associated with a decreased risk of coronary heart disease (CHD). An active lifestyle is necessary to improve HDL-C, including (but not limited to) physical exercise. Research on the association between badminton, an intermittent exercise, and HDL-C is limited. We investigated the impact of aerobic exercise and badminton on HDL-C levels in Taiwanese adults. The sociodemographic data of 7543 participants, comprising 3472 men and 4071 women aged between 30 and 70 years, were retrieved from the Taiwan Biobank. The participants were grouped into three exercise categories—no exercise, aerobic exercise, and badminton exercise. The HDL-C levels were compared using an analysis of variance (ANOVA). Multivariate linear regression models were used to determine the associations between HDL and exercise. Comparing the other two groups to the no-exercise group, the individuals who were engaged in aerobic and badminton exercise were significantly associated with higher HDL-C levels (β = 1.4077; p < 0.0001 and β = 5.6052; p = 0.0079, respectively). Aerobic exercise and badminton were also associated with higher HDL-C levels among carriers of the lipoprotein lipase (LPL) rs328 genotypes. Aerobic exercise and regular badminton were associated with higher levels of HDL-C, with the badminton group being more significant.
Dietary Potassium Attenuates the Effects of Dietary Sodium on Vascular Function in Salt-Resistant Adults
Authors: Smiljanec Katarina , Mbakwe Alexis , Ramos Gonzalez Macarena , Farquhar William B. , Lennon Shannon L.
Published: April 2020

The influence of dietary sodium and potassium on blood pressure (BP) has been extensively studied, however their impact on endothelial function, particularly any interactive effects, has received less attention. The purpose of this study was to determine if dietary potassium can offset the deleterious effect of high dietary sodium on endothelial function independent of BP. Thirty-three adults with salt-resistant BP (16 M and 17 F; 27 ± 1 year) completed seven days each of the following diets in a random order: a moderate potassium/low sodium diet (65 mmol potassium/50 mmol sodium; MK/LS), a moderate potassium/high sodium diet (65mmol potassium/300 mmol sodium; MK/HS) and a high potassium/high sodium (120 mmol potassium/300 mmol sodium; HK/HS). On day seven of each diet, 24-h ambulatory BP and a urine collection were performed. Brachial artery flow-mediated dilation (FMD) was measured in response to reactive hyperemia. Between diets, 24-h BP was unchanged confirming salt resistance (p > 0.05). Sodium excretion increased on both HS diets compared to MK/LS (p < 0.05) and potassium excretion was increased on the HK diet compared to MK/LS and MK/HS (p < 0.05) confirming diet compliance. FMD was lower in MK/HS (5.4 ± 0.5%) compared to MK/LS (6.7 ± 0.5%; p < 0.05) and HK/HS (6.4 ± 0.5%), while there was no difference between the MK/LS and HK/HS diets (p > 0.05). These data suggest that dietary potassium provides vascular protection against the deleterious effects of high dietary sodium by restoring conduit artery function.
Cropland Footprints of Australian Dietary Choices
Authors: Ridoutt Bradley , Anastasiou Kim , Baird Danielle , Garcia Javier Navarro , Hendrie Gilly
Published: April 2020

Food systems vitally depend on croplands, which are a scarce natural resource. Croplands are also heterogeneous, differing in productive capability and in environmental context. Some are in regions of high biodiversity conservation importance, others in regions vulnerable to food insecurity. In this study, life cycle assessment was used to quantify cropland scarcity footprints, cropland biodiversity footprints and cropland malnutrition footprints for 9341 individual Australian adult daily diets. Dietary cropland scarcity footprints averaged 7.1 m2yr-e person−1 day−1, exceeding a target of 6.1 m2yr-e person−1 day−1, consistent with the proposed global cropland planetary boundary of 15% of the ice-free land area. Discretionary foods, which are energy-dense and nutrient-poor foods high in saturated fat, added sugars and salt, and alcohol and are not essential to a healthy diet, made the largest contribution, followed by fresh meats and alternatives, breads and cereals, fruit, dairy and alternatives and vegetables. Around 45% of the variation in cropland footprint between individuals was explained by differences in total dietary energy intake. Diets characterised by higher diet quality and lower cropland scarcity footprint required only 4.2 m2yr-e person−1 day−1 and recommended diets based on the food choices of this subgroup required 5.9 m2yr-e person−1 day−1. Eating within the global cropland planetary boundary appears realistic if Australians greatly reduce their intake of discretionary foods and moderate their food choices within the “meat and alternatives” food group.
Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone
Authors: Hwang Jayeong , Youn Kumju , Ji Yeongseon , Lee Seonah , Lim Gyutae , Lee Jinhyuk , Ho Chi-Tang , Leem Sun-Hee , Jun Mira
Published: April 2020

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) mediate the degradation of acetylcholine (ACh), a primary neurotransmitter in the brain. Cholinergic deficiency occurs during the progression of Alzheimer’s disease (AD), resulting in widespread cognitive dysfunction and decline. We evaluated the potential effect of a natural cholinesterase inhibitor, zerumbone, using in vitro target enzyme assays, as well as in silico docking and ADMET (absorption, distribution, metabolism, excretion, and toxicity) simulation. Zerumbone showed a predominant cholinesterase inhibitory property with IC50 values of 2.74 ± 0.48 µM and 4.12 ± 0.42 µM for AChE and BChE, respectively; however, the modes of inhibition were different. Computational docking simulation indicated that Van der Waals interactions between zerumbone and both the cholinesterases were the main forces responsible for its inhibitory effects. Furthermore, zerumbone showed the best physicochemical properties for both bioavailability and blood–brain barrier (BBB) permeability. Together, in the present study, zerumbone was clearly identified as a unique dual AChE and BChE inhibitor with high permeability across the BBB, suggesting a strong potential for its physiological benefits and/or pharmacological efficacy in the prevention of AD.
Salt-Related Knowledge, Attitudes and Behaviors (KABs) among Victorian Adults Following 22-Months of a Consumer Awareness Campaign
Authors: Grimes Carley A. , Khokhar Durreajam , Bolton Kristy A. , Trieu Kathy , Potter Jane , Davidson Chelsea , Dunford Elizabeth K. , Jan Stephen , Woodward Mark , Bolam Bruce , Neal Bruce , Nowson Caryl , Webster Jacqui
Published: April 2020

The Australian population consumes more salt than recommended and this increases the risk of raised blood pressure and cardiovascular disease. In 2015, a state-wide initiative was launched in the Australian state of Victoria to reduce population salt intake. This study examines whether salt-related knowledge, attitudes and behaviors (KABs) of Victorian adults changed following the first 22 months of a consumer awareness campaign targeting parents. Repeated cross-sectional surveys of adults (18–65 years) recruited from research panels. Analyses were weighted to reflect the Victorian population. In both surveys mean age of participants (1584 in 2015 and 2141 in 2018) was 41 years, and 51% were female. This includes 554 parents/caregivers in 2015 and 799 in 2018. Most indicators of KAB remained unchanged. Among parents/caregivers the percentage who agreed limiting salt in their child’s diet was important increased by 8% (p = 0.001), and there was a 10% reduction in the percentage who reported placing a saltshaker on the table and a 9% reduction in those who reported their child added salt at the table (both p < 0.001). Some small adverse effects on other indicators were also observed. During the first 22 months of a salt reduction consumer awareness campaign, there were limited changes in KAB overall, however the target audience reported positive changes regarding their children, which aligned with the campaign messages.
Assessing Non-Invasive Liver Function in Patients with Intestinal Failure Receiving Total Parenteral Nutrition—Results from the Prospective PNLiver Trial
Authors: Blüthner Elisabeth , Pape Ulrich-Frank , Stockmann Martin , Karber Mirjam , Maasberg Sebastian , Pevny Sophie , Gerlach-Runge Undine , Pascher Andreas , Pratschke Johann , Tacke Frank , Bednarsch Jan
Published: April 2020

Liver abnormalities in intestinal failure (IF) patients receiving parenteral nutrition (PN) can progress undetected by standard laboratory tests to intestinal failure associated liver disease (IFALD). The aim of this longitudinal study is to evaluate the ability of non-invasive liver function tests to assess liver function following the initiation of PN. Twenty adult patients with IF were prospectively included at PN initiation and received scheduled follow-up assessments after 6, 12, and 24 months between 2014 and 2019. Each visit included liver assessment (LiMAx [Liver Maximum Capacity] test, ICG [indocyanine green] test, FibroScan), laboratory tests (standard laboratory test, NAFLD [non-alcoholic fatty liver disease] score, FIB–4 [fibrosis-4] score), nutritional status (bioelectrical impedance analysis, indirect calorimetry), and quality of life assessment. The patients were categorized post-hoc based on their continuous need for PN into a reduced parenteral nutrition (RPN) group and a stable parenteral nutrition (SPN) group. While the SPN group (n = 9) had significantly shorter small bowel length and poorer nutritional status at baseline compared to the RPN group (n = 11), no difference in liver function was observed between the distinct groups. Over time, liver function determined by LiMAx did continuously decrease from baseline to 24 months in the SPN group but remained stable in the RPN group. This decrease in liver function assessed with LiMAx in the SPN group preceded deterioration of all other investigated liver function tests during the study period. Our results suggest that the liver function over time is primarily determined by the degree of intestinal failure. Furthermore, the LiMAx test appeared more sensitive in detecting early changes in liver function in comparison to other liver function tests.
The Relationship between Vitamin D Metabolites and Androgens in Women with Polycystic Ovary Syndrome
Authors: Mesinovic Jakub , Teede Helena J. , Shorakae Soulmaz , Lambert Gavin W. , Lambert Elisabeth A. , Naderpoor Negar , de Courten Barbora
Published: April 2020

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, with hyperandrogenism present in up to 90% of affected women. Some evidence suggests a link between vitamin D deficiency and PCOS features via insulin resistance and inflammation. Our aim was to explore the relationship between biochemical markers of vitamin D status and androgens in women with PCOS. This cross-sectional study used bio-banked samples from 46 pre-menopausal women with PCOS (mean ± SD: age 30 ± 6 years; BMI 29 ± 6 kg/m2). We measured 25-hydroxyvitamin D (25[OH]D), vitamin D-binding protein (DBP), total testosterone, sex hormone-binding globulin (SHBG), and calculated the free androgen index (FAI) and bioavailable and free 25(OH)D. Fasting glucose and insulin were used to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) and body fat percentage was determined via dual energy x-ray absorptiometry. High-sensitivity C-reactive protein (hs-CRP) was measured as a marker of inflammation. DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. There were no associations between vitamin D metabolites and total testosterone, SHBG or FAI, even after adjusting for age, body fat percentage, HOMA-IR and hs-CRP. We found no associations between vitamin D metabolites and androgens in women with PCOS. Studies that have identified a vitamin D–androgen link have largely relied on methodology with numerous pitfalls; future studies should exclusively use gold-standard measures to confirm these findings in this population.
Extrauterine Growth Restriction: Definitions and Predictability of Outcomes in a Cohort of Very Low Birth Weight Infants or Preterm Neonates
Authors: Peila Chiara , Spada Elena , Giuliani Francesca , Maiocco Giulia , Raia Melissa , Cresi Francesco , Bertino Enrico , Coscia Alessandra
Published: April 2020

Extrauterine Growth Restriction (EUGR) refers to inadequate growth during hospitalization. Current definitions for EUGR are varied and can be classified as cross-sectional (weight at a given t-time <10th centile) or longitudinal (weight loss between birth and a given t-time >1SD). Different t-times are also considered in literature, such as 36 weeks of gestational age (GA) or age at discharge. The aim of this study is to investigate whether EUGR could predict the auxological outcome at 24–30 months, and to evaluate the agreement between cross-sectional and longitudinal definitions. In total, 1589 infants with GA <30 weeks or birthweight ≤ 1500 g and without major congenital anomalies were included in this study. Cross-sectional and longitudinal EUGR were calculated at 36 and 40 weeks of GA, at discharge, and at 28 days. The concordance between the two definitions was estimated by Kappa coefficient. At 24–30 months, 803 infants were measured again. The agreement between the two definitions of EUGR was low. Both EUGR and not-EUGR groups were at lower centiles for weight, but at higher centiles for head circumference at 24–30 months than at birth. Longitudinal EUGR was associated with a poorer growth outcome for weight and height circumference than cross-sectional EUGR. No differences were observed for length. An agreed definition of EUGR is highly desirable in clinical practice to assess medical and nutritional interventions in preterm neonates. Based on the results of this study, we recommend the use of the longitudinal evaluation, that proved to better predict the auxological long-term outcome with respect to the cross-sectional one.
LMX1B rs10733682 Polymorphism Interacts with Macronutrients, Dietary Patterns on the Risk of Obesity in Han Chinese Girls
Authors: Zhu Qi , Xue Kun , Guo Hong Wei , Yang Yu Huan
Published: April 2020

Previous studies have found that LMX1B rs10733682 polymorphism is associated with Body Mass Index (BMI) in European and American Indian adults. In this study, the association of rs10733682 polymorphism with obesity-related indicators, and its interaction with macronutrients and dietary patterns (DPs) were explored in Chinese children (n = 798). The rs10733682 polymorphism was genotyped by improved Multiple Ligase Detection Reaction (iMLDR). Four DPs were identified by factor analysis. The AA genotype had a higher incidence of overweight/obesity than GG+GA genotypes (P = 0.010) in girls (n = 398), but no difference in boys. The AA genotype in girls could interact with intake of energy, fat and carbohydrate, causing an increased triglyceride (TG), (P = 0.021, 0.003, 0.002, respectively), and also could interact with energy from protein, causing an elevated BMI (P = 0.023) and waist (P = 0.019). Girls inclining to the HED (high-energy density)-DP were associated with increased TG (P = 0.033), and girls inclining to the VEF (vegetables, eggs, and fishes based)-DP were associated with decreased total cholesterol (TC, P = 0.045) and decreased low density lipoprotein cholesterin (LDL, P = 0.016). The findings indicated that the AA genotype of rs10733682 and the HED-DP are potential risk factors of obesity in Chinese girls.
Interligando Educação Financeira e Matemática no Ensino Básico. Proposta didática para o 4.º ano
Authors: Fonseca Lina Maria Dias da , Bettencourt Mariana Costa
Published: April 2020

A formação dos alunos, em áreas diversificadas, é preocupação da escola, desde os anos iniciais da escolaridade. A necessidade de contribuir para o desenvolvimento da literacia financeira dos indivíduos, essencial para uma cidadania ativa e crítica, tem levado ao trabalho na área da educação financeira, tanto per si como associada, à matemática. No sentido de perceber que aspetos da educação financeira aprendem os alunos quando resolvem problemas que envolvem situações do dia a dia, desenhou-se um estudo de caso seguindo uma metodologia qualitativa. O caso era constituído por dezasseis alunos, com idades entre os 8 e os 10 anos, de uma turma do 3.º e 4.º anos de escolaridade. A recolha de dados recorreu a registos escritos dos alunos, a observação direta, registos fotográficos e áudio. Foi desenhada uma proposta didática que integrava uma sequência de 7 tarefas e permitiu trabalhar temas de educação financeira e da matemática. Os alunos revelaram conhecimento das moedas e notas de euro e das suas relações de equivalência. O conceito de semanada era do conhecimento de alguns, mas nem sempre o de poupar. Identificavam meios de pagamento, mas não estavam habituados a tomar decisões. Através das tarefas da proposta didática contactaram com noções de rendimento e de despesa, a simular pagamentos e trocos e a tomar decisões tendo em conta um rendimento estabelecido, mas também a desenvolver a capacidade de comunicar o seu pensamento aos colegas.
Lack of Histological and Molecular Signature Response to Tocilizumab in Kidney Transplants with Chronic Active Antibody Mediated Rejection: A Case Series
Authors: Kumar Dhiren , Yakubu Idris , Safavi Frough , Levy Marlon , Moinuddin Irfan , Kimball Pamela , Kamal Layla , King Anne , Massey Davis , Halloran Philip , Gupta Gaurav
Published: April 2020

Background

Traditional therapies for caAbMR have unclear efficacy with significant side effects in recipients of kidney transplants (KTs). A recent single-center case series suggested tocilizumab (TCZ) could stabilize renal function and improve microvascular inflammation. Here we report our findings of the use of TCZ in patients with caAbMR.

Methods

Ten adult recipients of KTs with biopsy-proven caAbMR were treated with TCZ at 8 mg/kg per month. Patients were monitored for adverse events, and therapy was interrupted in the setting of serious infections. Six patients (60%) underwent post-treatment biopsies.

Results

Patients (mean age of 43 years) were initiated on TCZ at a median of 36 months post-KT. A majority of patients were black (70%), underwent regrafts (40%), and were sensitized (mean cPRA=41%). Patients received a median of six doses of TCZ (range=3–10). At a median follow-up of 12 months (range=8–24 months), renal function did not show improvement (mean eGFR, 42±18 ml/min per 1.73 m2 to 37±24 ml/min per 1.73 m2; P=0.27). The slope of decline in eGFR remained unchanged (−0.14±0.9 to −0.33±1.1; P=0.25). There was no improvement in mean MVI (g+ptc) (4.8±1.4 to 4.2±2.0; P=0.39) scores or Molecular Microscope Diagnostic System (MMDx) AbMR scores (0.79±0.17 to 0.78±0.26; P=0.86). There was a numeric worsening of chronicity (ci+ct) scores (2.5±0.8 to 3.3±1.7; P=0.38) and MMDx atrophy fibrosis scores (0.36±0.24 to 0.58±0.15; P=0.21). Patient survival was 90%, with one patient death due to complications from a hip infection. Overall death-censored graft survival was 80%, with two graft losses in patients who had recurrent infections requiring hospitalization.

Conclusions

In this early experience, we report a lack of efficacy and toxicity with the use of TCZ for caAbMR. Prospective clinical trials are needed to clarify the role of IL-6 blockade and the possibility of increased incidence of infections in patients with caAbMR who are treated with TCZ.
uts ilmu sejarah naning yunia wati
Authors: Wati Naning Yunia
Published: April 2020

hasil analisis dokumen untuk pernyataan sejarah pendidikan era pra kolonialisme nusantara sampai reformasi.
Nearly 20+ compounds in Neem leaves extract exhibit high binding affinity with some of them as high as -14.3 kcal/mol against COVID-19 Main Protease (Mpro) : A Molecular Docking Study
Authors: Subramanian Shanmuga
Published: April 2020

Currently the new disease "COVID-19", caused by SARS-CoV-2, has infected nearly 3 million patients and nearly 200,000+ people have lost their lives due to this pandemic. There is an urgent need to find an antiviral agent that may slow down the spread of the virus. The aim of this study is to assess and evaluate compounds present in leaves of Neem tree (Azadirachta Indica) as potential inhibitors for COVID-19 Main Protease (Mpro) (PDB code: 6LU7). This will be done by blind molecular docking using PyRx and Auto Vina software. The compounds Hydroxychloroquine and Remdesivir were used for comparative study. The binding energies obtained from the docking of 6LU7 with Meliacinanhydride, IsoNimocinolide, Nimocino, 22, 23-dihydronimocinol, Nimonol, isomeldenin, zafaral, nimbandiol, Nimbin, Nimbanal, Nimbinene, Desacetylnimbin, Azadirachtin D, Azadirachtin B, Azadirachtin I, Azadirachtin A,2-tert-Butyl-1,3-diphenyl-4,5,6,7-tetrahydroindole, 3-Deacetylsalannin, Azadirachtin H,2′,3′-dehydrosalannol, Salannin (Azadriactin) were -14.3, -12.9, -12.3, -12.2, -12.2, -12.2, -12, -11.9, -11.8, -11.7, -11.7, -11.7, -11.4, -11.1,-10.8,-10.7,-10.6,-10.6,-10.6,-10.5,-10.2,-9.8 kcal/mol respectively. Therefore Meliacinanhydride (Ki=33.36 pM) and the compounds from Neem leaves may be a potential preventive treatment option against COVID-19. In addition to that the leaves contain others compounds like Quercetin, Zinc,Vitamin A,Vitamin B1,B2,B6, Vitamin C,Vitamin E etc., which may boost immunity also (Garba, 2019) .Further investigation is needed to evaluate the results of this study to consider Neem leaves as potential preventive treatment option as it might inhibit the virus and boost immunity also, thereby slowing the spread of COVID-19.
Peculiarities of hydration processes of cements containing natural zeolite
Authors: Sobol Khrystyna , Markiv Taras , Terlyha Volodymyr , Franus Wojciech
Published: April 2020

In this study, properties and peculiarities of hydration processes as well as paste microstructure of blended cements containing 10% by weight of natural zeolite were investigated. Free calcium hydroxide content, crystalline hydration products and microstructural architecture of hydrated cement pastes were examined by physical and chemical methods. It was found that the addition of natural zeolite provides formation of an extra amount of fine crystalline ettringite and tobermorite-like calcium hydrosilicates of CSH (B) type in the mineral non-clinker part of Portland cement resulting in strength synthesis of cement stone with high performance properties.
Long Method and Long Parameter List Code Smells Detection using Functional and Semantic Characteristics
Authors:   Research Scholar, Department of Computer Science & Engineering, M. M. Engineering College, M. M. (Deemed to be University) Mullana, Ambala, Haryana, India, Singh Randeep , Bindal Amit ,   Associate Professor, Department of Computer Science & Engineering, M. M. Engineering College, M. M. (Deemed to be University) Mullana, Ambala, Haryana, India, Kumar Ashok ,   Ex-Professor, Department of Computer Science & Engineering, M. M. Engineering College, M. M. (Deemed to be University) Mullana, Ambala, Haryana, India.
Published: April 2020

Long-term evolution and maintenance of the software system result in the introduction of different kinds of code smell in the underlying source code of the software system. These code smells are the direct indication of degraded quality and increased understandability and maintainability efforts at the developer’s end. Identification of these symptoms (code smells) that affects quality is an important aspect of software maintenance. Therefore, this paper targets identifying two key code smells, namely Long Method and Long Parameter List. The presence of these code smells directly affects the understandability and reusability of the underlying code. The proposed Long Method code smell detection technique depends on four main criteria, the size aspect of the method, Cyclomatic complexity of the method, functional relatedness of the method, and the semantic relatedness among different statements of the method. The proposed functional relatedness aspect at the method level is based on the idea of usage patterns present in the method. These usage patterns help in predicting functionality of the method and are a direct indicator of the fact whether the method is uni- functional (performs a single task) or multifunctional (performs more than one task). The proposed semantic relatedness is based on the tokens extracted at the method level and represents the importance of semantic (underlying concept) aspects at the method level. The proposed approach for Long Parameter List smell detection is also based on two important aspects, namely the size of the parameter list and the complexity of the data types used in the parameter list. The proposed approaches of this paper are experimentally validated and tested against state of the art existing approaches/ tools. The obtained experimental results point to the accuracy and relevance of the proposed approaches.
Utilization of Gardner’s Multiple Intelligence Theory for School Counselling System with Usability Testing
Authors:   Universiti Kuala Lumpur Malaysian Institute of Information Technology Kuala Lumpur, Malaysia, Ahmad Nik Azlina Nik , Dzulkarnain Sharifah Nina Shadzrina Syed ,   Universiti Kuala Lumpur Malaysian Institute of Information Technology Kuala Lumpur, Malaysia
Published: April 2020

Counselling unit plays a vital role at school as they deal with students’ problem and finding solutions to that. In most cases, students are not aware of their actual strength(s) which led to unsatisfied performance in academic and uncertainty in choosing the right courses which later affect their career. The aim of this research is to identify the evaluation criteria for Malaysian school students’ context in order to discover students’ major strengths, which in turn will help counsellors to consult students in terms of academic achievement and suggest suitable courses for them based on the intelligence test. The interview was conducted with several number of counsellors and the multiple intelligence theory was used to generate set of automated intelligence test based on the evaluation criteria. A series of evaluation were conducted to test its usability and quality requirements.
Method for Estimating the Performance of Enterprise Architecture Implementation in an Upstream Petroleum Industry
Authors:   Preparing Ph.D., Department of Information & Communication Technology, Universiti Teknikal Malaysia Melaka., Zuliansyah,* Mochammad , Desa Mohammad Ishak ,   Professor, Department of Intelligent Computing and Analytics, Department of Information and Communication Technology, Universiti Teknikal Malaysia Melaka., Ahmad Sabrina ,   Associate Professor & Deputy Dean, Department of Information and Communication Technology, Universiti Teknikal Malaysia Melaka.
Published: April 2020

Global oil prices have encouraged the development of the oil and gas industry. The passion for the revival of the oil and gas industry needs to be followed by solid steps. Efficiency is a theme in all business aspects. Enterprise Architecture (EA) is believed to be able to help realize the achievement of the company's goal. But EA implementation is challenging. The company must provide sufficient resources to ensure the EA implementation goal is achieved. It is therefore necessary to estimate the EA implementation to detect any gaps. This research offers a method to estimate the EA in the upstream petroleum industry. The method is a combined approach of Systematic Literature Review (SLR) and structured interviews. Interviews were conducted with a modified System Usability Scale (SUS) using the perspective of effectiveness, efficiency, agility, and durability. The evaluation results concluded that the EA implementation was still below the usability threshold. This fact encourages further EA development efforts, including the selection and utilization of specific and simple EA components.
Algorithm for Decreasing the Large Peak to Average Power Ratio in Mimo-Ofdm
Authors:   Research Scholar, Dept. of Electronics & Communication, Rabindranath Tagore University, Bhopal, Madhya Pradesh, India., khandagre* Yogeshver , Gupta Dr. Sanjeev kumar ,   Professor, Dept. of Electronics & Communication, Rabindranath Tagore University, Bhopal, Madhya Pradesh, India.
Published: April 2020

Every personal want to use high speed communication system but bandwidth is limited and users are unlimited in that case some of technologies are use for improving speed. One of the best technology called multiple inputs multiple outputs orthogonal frequency division multiplexing. Which provides very fast communication system but drawback of this technique is large maximum to average power ratio, these reduce efficiency of power amplifier. In this article developed new algorithm, for reduction of large maximum to average power ratio and improve bit or symbol error rate in MIMO-OFDM system. Proposed technique, called filter companding selected mapping algorithm technique (FC-SLM) to reduce PAPR using filtering and companding concept. In this techniques, after modulation of input data are converted into serial to parallel steam, phase mapping of all data from 0 to 360 degrees and perform IFFT operation, calculate PAPR and pass through desire range of filter and select minimum PAPR then perform companding and transmitted through an antenna. This scheme is reduce 2.3 dB PAPR and improve bit or symbol error rate. This is one of the most excellent promising techniques for next generation (5-G) communication system.
Using the Discount Cash Flow Model in Preliminary Assessment for Gold Mine Projects
Authors:   Mining and Petroleum Dept., Faculty of Eng., Al-Azhar University, Qena, Egypt., Allh* Eng/ Helal H. Hamd , Moharram Prof. M.R. ,   Mining and Petroleum Dept., Faculty of Eng., Al-Azhar University, Cairo, Egypt., Yassin Prof. Mohamed A. ,   Mining and Petroleum Dept., Faculty of Eng., Al-Azhar University, Cairo, Egypt, Embaby Assoc. Prof. A. Kh. ,   Mining and Petroleum Dept., Faculty of Eng., Al-Azhar University, Cairo, Egypt.
Published: April 2020

This study aims to the examination of the economic potential for the Abu Marawat Gold Project (AGP) in the Eastern Desert of Egypt and prediction the decision about go/not-to-go to invest in the deposit location. Discount Cash Flow (DCF) model used to calculate the Net Present Value (NPV) for the proposed gold mine project. NPV calculated by taking the risk and uncertainty produced from geological and technical factors into account. The actual production and cost data for Sukari Gold Mine (SGM) of Egypt used a benchmark for the theoretical calculation for production and cost data of AGP. From the valuation processes for AGP the NPV for the project predominantly positive, so, the project is acceptable to investment. This study aims to the examination of the economic potential for the Abu Marawat Gold Project (AGP) in the Eastern Desert of Egypt and predicts the decision about go/not-to-go to invest in the deposit location.
Critical Succsess Factors Decision Support System for SME
Authors:   Candidate Doctor of Computer Science Dept. Bina Nusantara Univ., Jakarta 11480, Indonesia., Inayatulloh*
Published: April 2020

Decision support system is part of information system to support decision making. This research purpose to identify the critical factors influence the successful implementation of decision support systems in SMEs.The purpose of this paper is also to analyze the part of decision support systems in SMEs to see the optimization of decision support system development. This research uses a methodology by identifying systematic literature from several sources from 2006 to 2019. The study found 42 articles relating to decision support systems and SMEs. The results of this research are the critical success factors of decision support system implementation in SMEs.
Wear Analysis of Compression Ignition Engine using Mesua ferea linn Methyl Eseter
Authors:   Pursuing PhD, Department of Mechanical Engineering, Central University, Assam, India., Shyam Biswajit , Borah Dr. Dilip Kumar ,   Department of Mechanical Engineering, IIT, Delhi, India., Kalita Dr. Kalyan ,   Department of Mechanical Engineering, IIT Guwahati, India.
Published: April 2020

As the standard of living is increasing day by day, the demand for energy consumption is also increasing due to the increasing population and expanding urbanization.At the same time,the whole world is aware about the depletion of petroleum reserves and its impact on environment pollution through exhaust emissions which has become a major threat to the whole world, so to deal with this there is an urgent need of suitable alternative fuels for use in diesel engine. Biodiesel is a suitable alternative fuel which is generally produced from renewable biological resources like vegetable oil and animal fats. It is biodegradable , non toxic, has lower emissions profile and at the same time environment friendly. In this study, biodiesel is prepared using mesua ferea linn(MFL)seed oil by transterification process. Two similar engines were operated for long turm endurance test using optimum biodiesel blend and petroleum-diesel oil, respectively. Atomic absorption spectroscopy (AAS) was used to check the wear debris concentration in lubricating oil samples which were drawn from both the engines after a fixed interval of time. Biodiesel operated engine showed lower wear debris concentration as compared to diesel operated engine. Scanning electron microscopy( SEM) showed lower damage of small disk of piston ring when operated with 20% biodiesel fuel, which revealed the better lubricity of biodiesel fuel. Also, carbon deposition of various parts like fuel injector, piston head were found to be lower in biodiesel used engine than that of diesel used engine.
Assorted Model of Sentiment using Mapreduce Framework
Authors:   Research Scholar, Department of Computer Application MANIT Bhopal (MP), India., Dhyani Saurabh , Thakur G. S. ,   Assistant Professor, Department of Computer Application MANIT Bhopal (MP), India
Published: April 2020

Social networking sites platforms, such as Facebook and Twitter, are being broadly used by community to share their feelings on different matters. Consequently, social networking site becomes an admirable and major open source for collecting public opinion. To perform sentiment analysis on such huge data, computational assorted models of single node are ineffective. Two ways to grip data that are big ,either by using super computers or by using parallel processing or by distributed processing. Where it is costly to use super computer, most models of parallel processing such as MPI, are difficult to implement and scaling, MapReduce is one of the parallel processing models that is highly scalable, tolerant to fault, and easy for using, in this research paper, we have proposed assorted model of sentiment analysis for twitter using MapReduce Framework. mapreduce based naïve bayes training algorithm was proposed for this purpose. Only single mapreduce job is executed for this algorithm which makes it different from earlier previous work. Training model is deployed to to classify million of tweets of twitter computers are costly, most parallel programming models, such as MPI, are difficult to use and scale. MapReduce is one of the parallel programming models that is highly scalable, fault tolerant and easy to use. This paper proposes a scalable framework for sentiment analysis of Twitter using MapReduce model. For this purpose a MapReduce based Na¨ıve Bayes training algorithm is proposed, this algorithm uses only one MapReduce job which makes it different from previous works. The trained model is deployed to classify millions of tweets. Accuracy and Scalabilty of our propsed model is well compared to previous models.
Construction of High Precision AC-DC Power Supply
Authors:   Department of Physics, Covenant University, Ota Nigeria., A. Akinpelu , R. Usikalu M. ,   Department of Physics, Covenant University, Ota Nigeria., A. Onumejor C. ,   Department of Physics, Covenant University, Ota Nigeria.
Published: April 2020

Several accessible power supply equipment with different difficulty levels and complexity mostly give a singular DC output that does not provide same use when an Output AC Power that is quite low to a great extent preferred. In this work, a stabilize, fixed and varying power supply device that has output voltage of 0.5 V to 18.15 V variable DC, and current range from 0 - 0.88 A with short circuit protection was constructed by using inexpensive materials, and fuse was used as circuit breaker . Likewise, we examined the regulation attributes of the power supply units that is just been constructed to a specific load regulation to decide its strength by contrasting it with a regular power supply device and ascertain the power supply's effectiveness through its efficiency. Test and examination were carried out utilizing the developed power supply unit to power loads of 10 to 50 Ω. The trend of the output results demonstrated that the power supply was in line with the standard PSU. The output supplied would be useful in research facility estimation to supply the power for direct incorporated circuits, delicate circuits, simple and advanced circuits, TTL and wide-ranging applications necessitating supply force.
Blockchain Technology Factor for Improve Good Distribution Practice in the Pharmaceutical Industry
Authors:   Department of Computer Science, BINUS Graduate Program – Doctor of Computer Science, Bina Nusantara University, Jakarta, Indonesia., Fernando Erick , Meyliana*  ,   Department of Information Systems, School of Information Systems, Bina Nusantara University, Jakarta, Indonesia., Warnars Harco Leslie Hendric Spits ,   Departmentm of Computer Science, BINUS Graduate Program – Doctor of Computer Science, Bina Nusantara University, Jakarta, Indonesia, Abdurachman Edi ,   Department of Computer Science, BINUS Graduate Program – Doctor of Computer Science, Bina Nusantara University, Jakarta, Indonesia.
Published: April 2020

The distribution process is one of the processes that occur in all industries, including the pharmaceutical industry. The distribution of medicines in the pharmaceutical industry is the most important to provide quality pharmaceutical products to patients or consumers. With several problems that occur in the distribution of drugs in things that currently should be considered. This happens a lot due to the many drugs that disagree with the provisions or such illegal or false drugs. This research investigates the use of blockchain technology for drug distribution in Indonesia. This research uses a systematic literature review method with related literature. The results of this research found 54 blockchain factors that were used to improve nine aspects of good distribution practices and to ensure the good quality of medicines distributed to consumers.
Hook Worm Detection and its Classification Techniques
Authors:   Student, Information Technology, Saveetha Institue of Medical and Technical Sciences, Saveetha University, Chennai, India., subramanian S Muthu , khilar Rashmita ,   Associate Professor, Information Technology, Saveetha Institue of Medical and Technical Sciences, Saveetha University, Chennai, India.
Published: April 2020

Wireless Capsule endoscopy (WCE) has transformed into a by and large used demonstrative strategy to look at some fiery infections and disarranges. Customized and completely robotized hookworm recognition and characterization models are testing task because of low nature of pictures, nearness of incidental issues, complex structure of gastrointestinal and various appearances to the extent shading and surface. There are a few endeavours were made to thoroughly research the robotized hookworm discovery from WCE pictures. A definite review is taken for identifying Hookworm in Endoscopy picture and its partner pre and post preparing specialized application. A profound report on AI system and highlight extraction approaches were examined. The different advances engaged with Hookworm location utilizing neural systems alongside their sorts were additionally talked about. The significant highlights which can be utilized for extricating the one of a kind highlights were considered.