bluuebunny/crossref_metadata_2025 huggingface dataset:
An impact of CMV and HHV-6 reactivation on the course of early period after hematopoietic stem cell transplantation in patients with hematologic malignancies
Authors: Antonova T. V. , Nozhkin M. S. , Pobegalova О. Е. , Gorchakova О. V. , Sabadash N. V. , Lioznov D. A.
Published: January 2023

Objective. To assess the impact of CMV and HHV-6 reactivation on the course of early post-transplant period in patients with hematologic malignancies.   Materials. Retrospective analysis of medical records of 339 patients with hematologic malignancies who received hematopoietic stem cell transplantation (HSCT) was performed, and markers of CMV and HHV-6 infections were detected (specific IgG, EIA). Blood and other materials from HSCT recipients were tested (PCR) for viral DNA in early post-transplant period (up to Day 100).

   Results. Reactivation of viral infections after HSCT was discovered in 177 patients (52,2 %): CMV-infection was detected in 23 %, HHV-6 in 17,4 %, CMV+HHV-6 in 11,6 % of HSCT recipients. CMV DNA was predominantly identified in blood, while HHV-6 DNA was more frequently discovered in GIT mucosa and bone marrow. 40 % of 99 patients with HHV-6 reactivation had concomitant CMV+HHV-6 reactivation. In this group, the clinical manifestation of infections was registered significantly more frequently. Febrile neutropenia was more frequent in HSCT recipients with CMV reactivation, sepsis and graft hypofunction were diagnosed more frequently in presence of HHV-6 and predominantly HHV-6+CMV infections. The direct correlation (using Spearman’s method) between CMV and HHV-6 reactivation and terms of leukopoiesis recovery, engraftment terms, and transplant hypofunction was revealed. An impact of herpetic infections reactivation on the graft hypofunction and late recovery of leukopoiesis was confirmed using the logistic regression; its impact on the chimerism was revealed. In 72 % of cases, the graft failure in early post-transplant period occurred in patients with herpetic infections reactivation.   Conclusion. HHV-6 and CMV reactivation in the early period after HSCT correlates with terms of leukopoiesis recovery, contributes to development of complications, and is an additional factor aggravating the course of the post-transplant period.
Сost-effectiveness of pentavalent rotavirus vaccination in the Russian Federation
Authors: Rudakova A. V. , Kharit S. M. , Rychkova S. V. , Lobzin Yu. V.
Published: January 2023

One of the main causes of acute gastroenteritis in children under 5 years of age is rotavirus infection (RVI). Vaccines against RVI significantly reduce the incidence.   Aim. To evaluate the cost-effectiveness of mass vaccination of children with a 5-valent RVI vaccine in the Russian Federation.   Materials and methods. The assessment was carried out using modeling based on published data on the effectiveness of the vaccine and epidemiological indicators in the Russian Federation. The analysis was carried out from the perspective of the health care system and society as a whole with a 5-year horizon. The cost of RVI therapy corresponded to the compulsory health insurance tariffs for St. Petersburg for 2022, the price of 1 dose of the vaccine was the registered price, including VAT. Costs and life expectancy, taking into account quality, were discounted at 3.5 % per year.   Results. Given the assumptions made, routine vaccination will prevent an average of 468,637 cases of RVI over 5 years. Avoided direct medical costs, i. e. RVI treatment costs will amount to 53,4 %, and lost income due to temporary disability – 46,6 % of the total avoided costs. At the same time, the volume of avoided costs is 61,4 % due to a decrease in morbidity in the vaccinated population, and 38.6 % due to the development of a indirect effect. The predicted avoided costs per 1 vaccinated person is 2,975 thousand rubles. From a societal perspective, the cost-effectiveness of the Rota-V-Aid vaccine will be 364,813 thousand rubles / QALY (quality-adjusted life year), and from a healthcare perspective – 1726,399 thousand rubles / QALY. Thus, in both cases, the cost-effectiveness of RVI vaccination will not exceed the generally accepted threshold of willingness to pay, equal to three times the gross domestic product per capita in the Russian Federation (according to data for 2021 – ~2,7 million rubles). The predicted cost-effectiveness of selective vaccination is significantly lower than that of mass vaccination.   Conclusions. Mass vaccination of children with a 5-valent vaccine against RVI will not only reduce the incidence in the Russian Federation, but, taking into account the assumptions made, can also be considered as a cost-effective intervention.
A clinical case of coinfection of COVID-19 and tropical malaria
Authors: Tuychiev L. N. , Akhmedova M. D. , Tadjieva N. U. , Anvarov J. A. , Eraliev U. E. , Husanov A. M. , Nazirov Sh. A.
Published: January 2023

The global outbreak of the new coronavirus infection COVID-19 is still ongoing, leading to coinfections such as malaria and COVID-19 and others. As evidenced by the increase in various reports of coinfections. In recent years, Uzbekistan has achieved epidemiological stability for malaria and in 2018 received an official World Health Organization certificate confirming the country’s “malaria-free” status. At the present stage during the COVID-19 pandemic, imported malaria from abroad is relevant for our republic and, therefore, there is a constant danger of renewed transmission from imported cases. In this article presented the clinical case of coinfection of COVID-19 and malaria in a patient. From the epidemiological data, the patient was a citizen of Cameroon. During treatment of coronavirus infection, the patient noted intermittent chills all over the body and sweating, clinical symptoms of tropical malaria began to appear. Microscopy of a thick drop and a thin blood smear confirmed the presence of Pl. falciparum. The patient was prescribed antimalarial therapy with mefloquine, resulting in clinical recovery.
Diagnostic features of multiple organic system disorders associated with COVID-19 in a child of primary school age
Authors: Fetisova S. G. , Starshinova A. Ya. , Kofeynikova O. A. , Starshinova A. A. , Sheyanova E. S. , Vershinina T. L. , Ryzhkov A. V. , Skripnik A. Yu. , Pervunina T. M. , Vasichkina E. S.
Published: January 2023

The advent of the COVID-19, specialists are increasingly encountering previously unknown pathological conditions in their practice. For some time, we have believed that COVID-19 in children is most often mild and asymptomatic. However, with the passage of time and the accumulation of the experience, it became obvious that the new infectious disease it will be quite severe in children. Differential diagnosis of multiple organ disorders in children during the COVID-19 pandemic should be primary carried out with the Multisystem Inflammatory Syndrome in Children, associated with COVID-19 (MIS-C), as well as Long-COVID-19. According to published data, the manifestations of these conditions are due to frequent lesions of the gastrointestinal tract (60–100 %), cardiovascular (80 %), nervous (29–58 %) and respiratory (21–65 %) systems. At present, there is no exact idea of these pathological conditions, the criteria for their diagnosis and the tactics of managing children, not only at the stage of diagnosis, but also at the stage of observation. The authors present a diagnostically complex clinical case describing the development of multiple organ damage in a 7-year-old child after contact with a mother who was sick with COVID-19. The data on the course features, the results of the examination and the difficulties of differential diagnosis of this case with other diseases with a similar clinic are summarized.
Measurement of Radioactive Concentrations and Determination of Isotopes Using Portable Devices for Radiochemistry Laboratories Al-Tuwaitha Nuclear Site in Iraq
Authors: Fadhil Hayder Rayed , Al-Alawy Iman Tarik , Al-Nasri Salam Kudhair
Published: January 2023

The measurements of radioactive concentrations using portable radiological devices for radiochemistry laboratories at the Al-Tuwaitha nuclear site (section C) were studied, section C consists of three laboratories, C1, C2, and C3 were used, Redeye device to measure the radioactive concentrations of alpha and beta emitters, and the Interceptor™ Specifications device to detect radioisotopes. The results showed the presence of radioactive contamination in Unit C distributed over most of its parts. In the C1 laboratory, the highest radioactive contamination was recorded in HCL2 with a concentration of 113.65Bq/cm2. In addition, the C2 laboratory recorded the highest radioactive concentration in FH1 with a concentration of 830.14Bq/cm2 for Beta particle emitters, while the C3 laboratory recorded the highest pollution in FH contamination with a radioactive concentration of 75.26 Bq/cm2. The results show that location C shows the isotopes detected in the laboratory components, such as Cesium 137Cs, Neptunium 237Np, and Americium 241Am. The results showed the presence of contamination on the laboratory floor in the fourth part, contaminated with Americium 241Am and Lutetium 167Lu isotopes. While location B did not record radioactive contamination in most of its parts except for room B8 which recorded radioactive concentrations of about 1.33 Bq/cm2. While location A, that is, no radioactive contamination was recorded, and the readings were within the permissible limits
Study of Phenotypic and Genotypic Factors of Staphylococcus aureus Clinical Local Isolates
Authors: Ali Ali Muhsin , Abdallah Muhannad Moeen
Published: January 2023

The isolates of Staphylococcus aureus were isolated from patients with various infections in hospitals, the isolates were identified and accurately diagnosed by phenotypic examination and biochemical tests, as well Vitek-2, and then genetic detection and diagnosis of many of the pathogenic factors associated with Staphylococcus aureus using conventional polymerase chain reaction (PCR) and testing for association by antibiotic resistance and production of some toxins by Staphylococcus aureus. After performing analysis of statistical, it was set up that the correlation coefficient of the PCR technique using virulence genes, sensitivity test to antibiotics and other virulence factors were significant at p < 0.05, but was insignificant with the biofilm production.
Aerosol-Assisted Chemical Vapor Deposition (AACVD) Technique of SrTiO3: B Thin Films and Study the Structural and Optical Properties and Hall Effect Measurements
Authors: Abdul-Hussein Yahya M. , Hussain Randa K. , Khalaf Mohammed K.
Published: January 2023

Aerosol-assisted chemical vapor deposition (AACVD) technique is very precise implemented to fabrication of structured SrTiO3 and Sr1-xBxTiO3 thin films at doping ratio (x = 2, 4, 6 and 8) % at temperature 400 °C on a glass substrate. The X-Ray Diffraction (XRD) patterns illustrated that the SrTiO3 and Sr1-xBxTiO3 thin films have a polycrystalline nature and cubic structure, the detailed characterization of the films by X-ray diffraction (XRD), the Surface Morphology studied by using (AFM) and (SEM). Have been noticed from AFM measurement the Roughness and RMS were increased with increases doping ratio. The optical properties of SrTiO3 and Sr1-xBxTiO3 thin films have been studied at doping ratio (x = 2, 4, 6 and 8) % at rate (300-900) nm. The transmittance spectrum is characterized by the opposite behavior of the absorbance spectrum. The transmittance generally increases with the increase in the wavelength of radiation, at wavelengths with low energies while the absorbance decreased slowly at spectrum rate (300-900) nm i.e. in the visible region. The band gap (Eg) is decreased at (3.2 - 2.5) eV which indicates that the doping process has led to the emergence of localized levels in the region confined by the valence and conduction bands, led to a reduction in the photon energy required for direct electronic transitions to occur. Found the carriers concentration charge are holes of Sr1-xBxTiO3 thin films at doping ratio (x = 2, 4, 6 and 8) %. Many properties can be improved by adding impurities such as Boron (B) to the SrTiO3, which can be used in solar cells, electronic industries or thermoelectric generators by controlling the optical or structural properties of the material by controlling the materials and percentages of impurity, or through heat treatment of the material, such as annealing, for example or exposure to different temperatures.
Artificial intelligence-based decision-making algorithms, Internet of Things sensing networks, and sustainable cyber-physical management systems in big data-driven cognitive manufacturing
Authors: Lazaroiu George , Androniceanu Armenia , Grecu Iulia , Grecu Gheorghe , Neguriță Octav
Published: January 2023

Research background: With increasing evidence of cognitive technologies progressively integrating themselves at all levels of the manufacturing enterprises, there is an instrumental need for comprehending how cognitive manufacturing systems can provide increased value and precision in complex operational processes.
Purpose of the article: In this research, prior findings were cumulated proving that cognitive manufacturing integrates artificial intelligence-based decision-making algorithms, real-time big data analytics, sustainable industrial value creation, and digitized mass production.
Methods: Throughout April and June 2022, by employing Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, a quantitative literature review of ProQuest, Scopus, and the Web of Science databases was performed, with search terms including ?cognitive Industrial Internet of Things?, ?cognitive automation?, ?cognitive manufacturing systems?, ?cognitively-enhanced machine?, ?cognitive technology-driven automation?, ?cognitive computing technologies,? and ?cognitive technologies.? The Systematic Review Data Repository (SRDR) was leveraged, a software program for the collecting, processing, and analysis of data for our research. The quality of the selected scholarly sources was evaluated by harnessing the Mixed Method Appraisal Tool (MMAT). AMSTAR (Assessing the Methodological Quality of Systematic Reviews) deployed artificial intelligence and intelligent workflows, and Dedoose was used for mixed methods research. VOSviewer layout algorithms and Dimensions bibliometric mapping served as data visualization tools.
Findings & value added: Cognitive manufacturing systems is developed on sustainable product lifecycle management, Internet of Things-based real-time production logistics, and deep learning-assisted smart process planning, optimizing value creation capabilities and artificial intelligence-based decision-making algorithms. Subsequent interest should be oriented to how predictive maintenance can assist in cognitive manufacturing by use of artificial intelligence-based decision-making algorithms, real-time big data analytics, sustainable industrial value creation, and digitized mass production.
Digital transformation and corporate cash holdings in China's A-share listed companies
Authors: Sun Changling , Lin Ziang , Vochozka Marek , Vincúrová Zuzana
Published: January 2023

Research background: In the digital era, digital transformation has become a strategic imperative for leadership agenda. Many firms have accelerated their pace in digital transformation to improve their performance and competitiveness. Despite increasing attention in the literature on the role of digital transformation in firms? operations, understanding the effect of digital transformation on corporate finance remains limited. This study focuses on cash holdings, which are essential for firms to survive and thrive.
Purpose of the article: The aim of this paper is to examine the critical role of digital transformation on the cash holdings of listed firms in China and provide micro evidence regarding the economic consequences of the digital economy from firm level. This study also aims to deepen our understanding of the influence of digital transformation on firms? operation and financial policy. Additionally, this paper attempts to provide relevant guidance for implementing policies to promote digital transformation and devise corresponding cash holding strategies.
Methods: The text analysis method is used to measure the degree of digital transformation of China?s A-share listed companies. The sample covers 19,337 observations from 2007?2020. A multiple regression model with firm and year fixed effect is developed to investigate the relationship between digital transformation and corporate cash holdings. In the robustness test, this paper substitutes the independent and dependent variables, and adopts instrumental variable estimation method. In the mechanism test, this paper uses the sub-sample regression method in the mechanism test.
Findings & value added: This study reveals that digital transformation can significantly reduce corporate cash holdings by alleviating the precautionary motive, agency motive and transaction motive of cash holdings. Further analysis shows that the negative effect of digital transformation on cash holdings is more profound in high-tech firms and non-state-owned enterprises. The methodology applied in this paper can be used in other economic research of firms. This study provides insights into the effects of digital transformation on corporate financial policy. This provides a solution for reducing firms? cash holdings. This study also deepens the understanding of digital transformation from a corporate perspective.
Earnings management model for Visegrad Group as an immanent part of creative accounting
Authors: Kováčová Mária , Hrosova Lenka , Durana Pavol , Horak Jakub
Published: January 2023

Research background: Creative accounting practices do not frequently violate the law and are not considered illegal; however, accounting managers may exploit legal ambiguities to portray the company's financial standing in accordance with management preferences. Therefore, the analysis is focused on the detection of earnings management in companies operating in the Visegrad Group, which represents one of the most commonly used techniques for revealing creative accounting.
Purpose of the article: The aim of the presented study is to reveal the presence of creative accounting through the detection of earnings management in the countries of the Visegrad Group and, based on the detected results, to propose a regression model of earnings management in the Visegrad Group.
Methods: To reveal the use of creative accounting in the Visegrad Group, ten selected models of earnings management were applied during the period 2016?2020 to a set of 8,134 companies. The Mann-Whitney test and multiple linear regression were used to verify the existence of earnings management. These findings served as the basis for the creation of the linear regression model of earnings management in the Visegrad Group.
Findings & value-added: The presence of earnings management was best captured by the Hribar and Collins model in companies operating in the Visegrad Group in the period 2016?2020. The findings also confirmed that positive discretionary accruals acquired higher values over the entire period when compared to negative discretionary accruals, confirming that companies in the surveyed group manage their profits primarily by increasing them. Therefore, we created a regression model, that can serve as a unique basis and is capable of revealing the use of earnings management in the Visegrad Group, as until now nothing like this has been implemented in these countries. In conclusion, this study offers insights for academicians and researchers on creative accounting in the selected period. Lastly, the study contributes to the existing theory by conducting new research on the earnings management determinants of the countries studied.
"Una muchacha, a quien crío para condesa": El personaje de Sanchica en el segundo Quijote cervantino
Authors: Altamirano Magdalena
Published: January 2023

Este artículo analiza las funciones de la hija de Sancho Panza en el segundo Quijote y concluye que Sanchica es fundamental para el desarrollo de ciertas facetas de Sancho y Teresa; notablemente, de las ansías desmesuradas de ascenso social. Por su hipotético matrimonio con un conde, Sanchica es pieza esencial en el proyecto arribista de Sancho; la indumentaria y las actividades de la muchacha facilitan tanto la extensión de la burla ducal hasta la aldea como la reversión de la farsa orquestada por la duquesa. Sanchica también arroja luz sobre la situación de las campesinas de la temprana modernidad española.
Breve historia de la prosa completa de Quevedo (1648-2020)
Authors: Rey Alfonso
Published: January 2023

Además de su amplia producción poética, Quevedo posee otra de carácter prosístico, constituida por narraciones, tratados teóricos y sermones. En éstos mantuvo una coherente ideología estética, moral y política, de modo que para comprender su visión del mundo conviene entender su obra en prosa como un todo. El presente texto ofrece un rápido recorrido por las ediciones de sus obras completas en prosa desde 1646 hasta 2020.
Alonso de Fuentes, Cuarenta cantos de diversas y peregrinas historias (Doménico de Robertis, Sevilla, 1550). Ed. facsimilar con est. introd. de Vicenç Beltrán. Coord. de José J. Labrador Herraiz. Frente de Afirmación Hispanista A.C., México, 2020; 713 pp.
Authors: Ventura Escudero Luis Carlos
Published: January 2023

Alonso de Fuentes, Cuarenta cantos de diversas y peregrinas historias (Doménico de Robertis, Sevilla, 1550). Ed. facsimilar con est. introd. de Vicenç Beltrán. Coord. de José J. Labrador Herraiz. Frente de Afirmación Hispanista A.C., México, 2020; 713 pp.
New therapeutic strategies based on molecularly targeted therapy in glioblastoma – a case report and review of the literature
Authors: Szklener Katarzyna , Rodzajewska Anna , Kurylo Weronika , Mandziuk Slawomir
Published: January 2023

Glioblastomas are the most common and most lethal forms of malignant primary brain tumor. We present a case report of a patient with III-grade glioma who achieved stable disease (SD) and clinical improvement after trametinib administration. We also report a review of the literature to Current Treatment Guidelines of Glioblastoma and new therapeutic strategies based on molecularly targeted therapy. Traditional treatments, including surgery, radiotherapy, and chemotherapy, have many limitations concerning the prognosis of patients with glioblastomas. Unfortunately, these tumors’recur after primary resection in the majority of cases. There is no standard therapy for recurrence of GBM. Targeted therapy offers a promising new treatment strategy. Regardless of those outstanding results much more can be done in the field of therapeutic options. Most urgent concerns include potent combining molecular targeted therapy with other types of treatments, selecting a group of patients for whom they turn out to be the most beneficial, and addressing adverse events of these molecules.
A comparative review on High-Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC) & High-Performance Thin Layer Chromatography (HPTLC) with current updates
Authors: Gupta Manish Kumar , Ghuge Aditya , Parab Manasi , Al-Refaei Yehya , Khandare Anjali , Dand Neha , Waghmare Nilkamal
Published: January 2023

Any chosen analytical method should be subtle, precise, fast and exact to begin the guarantee that the material used in the manufacturing is free of unsolicited impurity, the existence of which may vary the safety and effectiveness of the drug product. The techniques of HPLC and UPLC have established their part in pharmaceutical cleaning validation. High-Performance Liquid Chromatography (HPLC) is the main pharmaceutical and biomedical analysis approach utilized today because it generates highly efficient separations, and in most circumstances, it provides high detection sensitivity. Applying the HPLC method has several advantages compared to other methods, among others, specificity, rapidity, accuracy, precision, and the ease of automation. Due to the aforementioned, most drugs in a multi-component dosage form can be analyzed. Ultra-Performance Liquid Chromatography (UPLC) is a modern-day technique that gives a new track for liquid chromatography. UPLC provides the user with speed of application, resolution and sensitivity. The quantification and separation in UPLC are done under very high pressure (up to 100M Pa). High-Performance Thin Layer Chromatography (HPTLC) has improved and innovative separation efficacy and detection limits. It is a cultured and automated form of Thin Layer Chromatography (TLC) and is based on the use of an optimized silica gel 60 with a significantly smaller particle size than which is used for TLC. The previously stated analytical methods are employed for purity control of chemicals, steroids, pesticides, and water analysis, water-soluble food dyes, vitamins, pesticides in vegetables, fruits, and other foodstuffs. The current updates in the techniques allow us to understand the increased utilization of these methods in the current eras.
Synthetic seeds technology of Salvia officinalis as a method for short-term storage and in vitro propagation of valuable genotypes
Authors: Deja Aleksandra K.
Published: January 2023

Introduction: The technological advancements in the production of synthetic seeds are critical for the preservation of valuable genotypes of many herbal plants, including Salvia officinalis – sage.

Objective: The aim of this study was the production, storage and conversion of artificial sage seeds. The technology of synthetic seeds is placing explants capable of regeneration into plants in a protective casing.

Methods: Apical and axillary buds were encapsulated with 1.2% sodium alginate solution, and then dripped in 200 mM CaCl2 solution. Artificial seeds were stored at 4°C for 30 days and then converted on MS medium containing 0.3 mg/l of BAP.

Results: The synthetic seeds technology made it possible to obtain a high level of seeds conversion into plants using apical buds (85.0%), and slightly lower in the case of side buds (62.5%).

Conclusion: The fully developed technology of synthetic seeds made it possible to obtain a high level of plant viability, which may prove useful for the storage of valuable genotypes of sage.
Gingival Enlargement Caused by Calcium Channel Blockers
Authors: Desnica Jana , Vujovic Sanja , Stevanovic Momir , Vasovic Miroslav , Stanisic Dragana , Ognjanovic Irena , Rosic Gvozden , Jankovic Slobodan , Jovicic Nemanja , Kostic Marina
Published: January 2023

Calcium channel blockers, a group of drugs widely used in the treatment of cardiovascular patients, although effective, often cause gingival enlargement, a side effect that is rarely recognized in clinical practice and is not given sufficient importance. Gingival enlargement caused by calcium channel blockers can be localized or generalized, mild or severe. It can negatively affect patients’ appearance, mastication, and speech, thus considerably reducing the quality of life of patients. Risk factors and pathogenesis of this side effect have been the subject of many studies but are still unknown, making this condition a major therapeutic challenge, especially if the cessation of the offending drug is not possible. This study aimed to review the etiology, potential risk factors, pathogenesis, clinical features, and therapy possibilities for gingival enlargement caused by calcium channel blockers.
Systemic Diseases with Oral Manifestations and Their Impact on Health-Related Quality of Life
Authors: Vujovic Sanja , Desnica Jana , Stanisic Dragana , Ognjanovic Irena , Milenkovic Jovana , Stevanovic Momir , Rosic Gvozden , Jovicic Nemanja , Milovanovic Dragan
Published: January 2023

Health-related quality of life is a multidimensional concept established to evaluate the physical, psychological, and social impacts of health conditions on individuals’ well-being. Various tools for measuring health-related quality of life can be categorized into two subsets: generic and disease–specific instruments. The oral cavity can be stricken by a broad range of local and systemic diseases and their systemic treatment modalities. The most common systemic illnesses associated with oral lesions are hematologic disorders, endocrinopathies, neurological disorders, gastrointestinal conditions, mucocutaneous and rheumatic diseases, and neoplastic processes. Their manifestations in the oral cavity are, in most cases, rather nonspecific but should not be overlooked. Oral health is one of the most important parts of overall health, thus it has been proposed that poor oral health may affect health–related quality of life. The presence of oral manifestations of systemic diseases has a negative impact on the daily functioning of patients, decreasing their overall well-being. This article will review the most common systemic diseases with oral manifestations and their impact on the health–related quality of life. Oral health researchers should put a stronger emphasis on the patient-reported quality of life as a primary outcome in future clinical trials. The significance of this area has still not been widely understood in the current dental literature even though it could help improve patients’ health-related quality of life.
Identificación de sitios con potencial para captar agua de lluvia en la Cuenca Alta del Río Mixteco, Oaxaca, México
Authors:   Universidad Tecnológica de la Mixteca, Huajuapan de León, Oaxaca, México, Álvarez-Olguín Gabriela , Sustaita-Rivera Fidencio ,   Universidad Tecnológica de la Mixteca, Huajuapan de León, Oaxaca, México, Morales-Luis René ,   Universidad Tecnológica de la Mixteca, Huajuapan de León, Oaxaca, México
Published: January 2023

Los sistemas de captación de agua de lluvia (SCALL) son una alternativa para resolver los problemas de suministro de agua en la Cuenca Alta del Río Mixteco (CARM). Sin embargo, el éxito de la adopción de un SCALL depende en gran medida de su diseño técnico y de la selección de un sitio adecuado para su construcción. El objetivo de este trabajo fue identificar sitios apropiados para la construcción de SCALL en la CARM, a través de una modelación hidrológica con QSWAT+ (QGIS Interface for Soil and Water Assessment Tool) y el análisis de información geográfica. Se determinó que los sitios con potencial para la construcción de SCALL abarcan 7 % de la superficie de la cuenca, donde se podrán construir presas de contención y tanques de percolación, para macrocaptación y almacenamiento de agua de lluvia; además, terrazas, barreras y zanjas al contorno, para reducir la velocidad de escurrimientos superficiales y la erosión de los suelos. De esta forma aumentará la disponibilidad de agua en la cuenca para diversos usos y se favorecerá la conservación del suelo y agua.
Chylopericardium causing cardiac tamponade in a patient with lymphangioleiomyomatosis
Authors: Fong Isaac Jun Jie , Ruan Xu Cong , Keh Yann Shan , Tan Yi-Hern
Published: January 2023

Background:

Chylopericardium is a rare entity characterized by the accumulation of chylous fluid in the pericardial cavity. Lymphangioleiomyomatosis (LAM) is a rare, progressive systemic disease with prominent features of lung cysts, abdominal tumors, and the development of chylous effusions, usually in the thorax and/or abdomen. Chylopericardium in association with LAM is exceedingly rare, with only a few cases reported in the literature.

Case Presentation:

We report a case of a 61-year-old woman with chronic dyspnea and bilateral cystic lung disease who presented with a 1-week history of acutely worsening dyspnea. At presentation, she was tachycardiac and hypoxemic, an electrocardiogram detected sinus tachycardia, and a chest radiograph was indeterminate for a small right apical pneumothorax or an apical bulla. An urgent echocardiogram revealed a large pericardial effusion with features of cardiac tamponade, necessitating urgent pericardiocentesis. Analysis of the pericardial fluid confirmed the presence of chylopericardium and a diagnosis of LAM was made. Oral Sirolimus was started and at 1 year of follow-up, the patient has successfully avoided repeat pericardiocentesis.

Conclusion:

This case describes a rare presentation of a rare disease and suggests that treatment with sirolimus may potentially be effective in reducing the accumulation of chylopericardium in LAM.
Approaches to imported malaria prevention, management, and elimination in Jazan, Kingdom of Saudi Arabia
Authors: Asiri Mohammed , Alghathami Wail , Asiri Ahmed , Qahl Mohammed
Published: January 2023

Malaria is a problem to public health particularly in endemic areas, being a major cause of illness and death. Thus, this study aimed to summarize updated information regarding approaches to imported malaria prevention, management, and elimination in Jazan in the Kingdom of Saudi Arabia (SA). This review was performed through an electronic literature search for relevant studies identified using keywords on the MEDLINE database, including malaria infection, prevalence, diagnosis, and management. Similar keywords were used to search and identify relevant articles on Google Scholar. Anti-malarial medications could be used to manage positive malaria diagnosis including Artemisinin-based combination therapies, Chloroquine with proguanil, and atovaquone with proguanil to cure the disease. Vector control plays a great role in controlling and eliminating malaria, and the two core widely applicable control measures are long-lasting insecticide-treated nets and indoor residual spraying. In addition, surveillance is a great strategy for preventing infection. There is a surveillance system for malaria in SA, and it is mandatory for primary health centers and hospitals to report 24 hours of all cases of malaria to the elimination program unit. Moreover, vaccination is a core public health intervention for infection prevention and control. However, there is no licensed vaccine for the prevention of malaria.
Questionnaire regarding community awareness of circumcision-related aspects in Saudi Arabia
Authors: AlOtay Abdulhakim , Helaly Ahmed , Alsaleh Faisal , Alsubaie Nawaf , Alshehri Mansour
Published: January 2023

Objective: The aim was to evaluate different aspects related to early male circumcision, community awareness, and family satisfaction.
Methods: A questionnaire-based survey was conducted with the following items on circumcision; time, technique, the performing medical practitioner, and where the circumcision was conducted. Alongside, other questions regarding family satisfaction and cases needing redo circumcision were also included in the questionnaire.
Results: The number of participants was 1,118. Timing of circumcision most commonly was neonatal period, first year circumcision, then later throughout their life. Circumcisions were mostly performed in hospitals and carried out by pediatric surgeons. Complications of circumcisions were encountered in 6.9% of cases and circumcision was not affected by the physician's specialty, timing, place, or technique of circumcision.
Conclusion: Ritual circumcision (circumcision in community) is the most common practice. Family counselling regarding postoperative care and sequelae is of utmost importance. Revising practice and audits on circumcision are to be encouraged.
Wind Energy and Assessment of Wind Energy Potential in Turkey: A Case of Study from Sinop Province
Authors: Dağtekin Metin , Yelmen Bekir
Published: January 2023

Due to the emerging needs in parallel with the developing technology and industrialization, the importance of renewable energy sources is increasing with the decrease of usable fossil resources and the ever-increasing need for energy. For this reason, solutions are sought to provide the energy needed in a timely, sufficient, and reliable manner. Wind energy has the greatest potential and usage area among renewable energy sources. The wind, which has advantages such as clean, fast commissioning, reliability, and being independent of fuel, is considered a good example of a clean energy source with these features. In this study, the production potential of electrical energy from wind energy was investigated by using wind data for Sinop province. Wind energy potential on the availability of wind energy systems suitable for its natural structure for Sinop province; Visual Basic 6.0 was determined using the computer package program. In the study, hourly wind data were used and analyzes were made for suitable wind energy systems. In addition, for a possible WPPs, analysis has been made and evaluated considering the current data; The availability of wind energy in Sinop province has been tried to be revealed.
Determination of Aflatoxin M1 in Buffalo Milk and Products
Authors: Hepçin Serhat , Gücükoğlu Ali
Published: January 2023

This study aimed to investigate the presence of Aflatoxin M1 (AFM1) in raw buffalo milk and buffalo milk products such as cheese, yogurt, cream, and ice cream by ELISA technique. In the study, 175 samples were investigated, and it was determined that 146 (83.43%) of the samples had AFM1 concentrations below the LOD (limit of detection) value. In 29 samples (16.57%), the AFM1 concentration exceeded the LOD value, and in 7 (4%) of these, the AFM1 concentration was above the legal limits (50 ng/L). While AFM1 was not detected in raw buffalo milk samples, the presence of AFM1 in cheese, yogurt, cream, and ice cream samples was found to be 2.85%, 2.85%, 62.85%, and 14.3%, respectively. 2.85% of cheese samples and 17.1% of cream samples were found contaminated with AFM1 above the allowed legal limits (50 ng/L). As a result, it was determined that the potential for exposure to AFM1 by consuming buffalo cream was higher than the consumption of buffalo milk and other buffalo milk products. However, the detection of AFM1 above legal limits in buffalo milk products poses a serious risk to public health. Therefore, it is extremely necessary for public health to develop effective monitoring programs to control aflatoxin contamination in milk and new strategies to maintain inspections.
Investigation of Beta-lactam Group Antibiotics Residue in Raw Cow Milk in Sivas Province
Authors: Ercan Nazlı , Ağaoğlu Sema
Published: January 2023

In this study, beta-lactam group antibiotic residues were investigated in raw cow's milk. For this purpose, a total of 86 raw milk samples were used as material. Samples were collected periodically from farms in various outlets and surrounding villages in the province of Sivas. Beta-lactam group antibiotic levels in raw cow's milk were determined by ELISA method with commercial test kit. According to the analysis results, beta-lactam levels were between 0.35-0.70 ng/mL in 64 (74.4%) and between 0.71-3.7 ng/mL in 22 samples (25.6%) determined of 86 raw cow milk samples. The residue levels detected in the samples are in accordance with the legal limits declared by the European Union (EU) commission and Turkish Food Codex Communique.
Effects of Forage Legumes Sowing in the Fallow Year on Silage Yield and Quality Characteristics of Subsequent Cereals
Authors: Saylan Musa , Avcı Süleyman
Published: January 2023

In this study, the effect of P. arvense-H. vulgare mixture and V. pannonica grown in the fallow year on silage yield and quality of subsequent cereals were investigated in the arid condition of Eskişehir, Turkey. The fresh weight of P. arvense-H. vulgare mixture with 2750 kg/da was found two-fold high than V. pannonica. P. arvense-H. vulgare mixture significantly increased the fresh and dry hay weights of cereals except for H. vulgare cv. İnce. In addition, the highest grain yield was obtained by growing Triticosecale cv. Karma in P. arvense-H. vulgare mixture plots. Due to the high pH and low dry matter content of triticale samples, the Fleig scores were very low, which is a quality indicator in silage. ADF and NDF ratios were the highest in A. sativa cv. Checato as a negative quality factor. Top-dressing of nitrogen had a positive effect on the crude protein ratio. It was concluded that production of quality roughage can be sustainably increased by growing P. arvense-H. vulgare mixture in barren areas in the fallow year and followed by sowed cvs. Karma, Müfitbey, and Checato in the cereal growing season.
Influence of Ensiled Guinea Grass-Cassava Peels Enriched With Soybean Waste on Performance of West African Dwarf (WAd) Goats
Authors: Ogunbosoye Dupe Olufunke , Taye Olurotimi Abegunde , Abayomi Akinfemi
Published: January 2023

The study was conducted to investigate the effects of ensiled guinea grass (GG)- cassava peel (CSP) enriched with soybean cheese waste (SBCW) in varying proportions into 4 treatments: T1 (GG100%), T2 (GG80% + CSP10% + SBCW10%), T3 (GG60% + CSP30% + SBCW10%) and T4 (GG40% + CSP50% + SBCW10%) on West African Dwarf goats. Twenty WAd goats were allocated into four silages of five growing WAd goats each. Daily feed intake and weekly weight gain were measured for twelve weeks of the experiment. Digestibility study was carried out using Three animals per treatment for faeces and urine collection. Blood samples were collected via jugular vein for blood profile analysis using standard measures in a completely randomized design. The Crude protein (CP) concentrations of silage increased with the increasing level of cassava peels. Crude fiber levels of the silages also followed the same trend. The group of animals fed T4 had highest feed intake among the treatment groups. Daily weight gain of goats in T4 was better enhanced than other treatments. The apparent digestibility was significantly different (P˂0.05) among the treatment groups. There were diet effects on the parameters measured for rumen liquor of the animals fed silages. The treatments had no effects on the haematology and total protein of goats fed diets. It is therefore indicated that agro-industrial by-products ensiled with guinea grass are potential means of feed sustainability during the dry season period for goats in Nigeria without any deleterious effects on goats’ health and performance.
Estimating and Identifying Factors Influencing Households' Willingness to Pay for Conservation of Washera Sheep Breed in Selected Areas of West Gojjam Zone, Ethiopia
Authors: Bezu Kebebew Hundie , Wase Awoke Melak , Ayale Tesfalem Aseged , Banja Tadesse Hunduma , Kasa Abebe Hailu , Tujuba Tesfu Fekensa
Published: January 2023

The purpose of this study was to estimate and identify factors affecting the willingness of households to pay for conservation of Washera sheep in West Gojam, Ethiopia. This study used both primary and secondary data. A three-stage sampling method was used to collect data from 240 respondents. Data were analyzed using descriptive statistics and econometric models. The two-dimensional test model used a method to determine the choice of the imputation method using double limited dichotomies. The study showed that education level, livestock size, extension contacts and credit source positively affected the maximum household’s willingness to pay for conservation of Washera sheep. On the other hand, age, sex, land size, and the distance of the home from the household’s market have negatively affected the maximum household’s willingness to pay for conservation of Washera sheep. Meanwhile, the total number of valid answers corresponds to 122,168 households. Therefore, the mean willingness to pay for Washera sheep conservation was US$ 3.75 per year and the total economic benefit gain from Washera sheep conservation were equivalent to US$1,069,647.23. The study recommends that households be willing to contribute to the conservation of Washera sheep breed by providing the cash. This ensures community participation in all decision making and formulation of plans and policies related to the conservation of Washera sheep breeds.
Effect of Pink Rock Rose Extract with or Without Ascorbic Acid and Sodium Ascorbate for the Preservation of Ready-to-Eat Frankfurter Type Sausages
Authors: Gedikoğlu Ayça , İnci Öztürk Hale , Buzrul Sencer , Sökmen Münevver , Aytaç Ezgi
Published: January 2023

This study aimed to determine the effect of pink rock rose extract (PRR) with or without ascorbic acid and sodium ascorbate for improving the shelf life of sausages. Analyzed parameters were DPPH radical scavenging capacity of PRR extract; total aerobic count, thiobarbituric acid reactive substance, heme iron, pH, water activity, proximate composition, and color values of MAP packaged sausages for 12 weeks at 4 °C. Treatments: (1) Control (0.02% ascorbic acid and 0.05% sodium ascorbate – AA-SA), (2) electrostatic spray application of PRR extract (2%) – ES-PRR, (3) 0.02% AA and, 0.05% PRR extract, (4) 0.05% SA and 0.02% PRR, (5) 0.07% PRR extract. PRR extract had the half maximal inhibitory concentration (IC50) value of 13.04 ± 0.133 µg/mL. Sausages formulated with 0.07% PRR had the lowest microbial growth rate, followed by AA-PRR formulation. The AA-PRR treatment had the lowest TBARS values for most of the storage. This study reveals that PRR extract can be added as a natural antioxidant in sausages, and it could be used as a replacement or for the reduction of ascorbic acid and sodium ascorbate in sausage formulations.
On-Farm Adaptation to Climate Change: Assessment of Effects of Groundwater-Based Deficit and Supplementary Irrigation on Soil Quality Under Semi-Arid Ecosystems
Authors: Mashi Sani Abubakar , Ibrahim Inkani Amina , Yaro Abdu
Published: January 2023

Agriculture is one of the sectors most affected by climate change, especially through the reduction in the number of rainy days in semi-arid areas, which require deficit supplementary irrigation (DSI) to minimise crop failures. Few studies have utilised soil quality indices (SQIs) to evaluate the quality changes of soils under DSI practices in semi-arid agricultural ecosystems. This paper examines the effects of DSI activities on soil quality in the Ingawa area of Nigeria’s semi-arid region. Plots subjected to different years of DSI (3, 5, 6, 8, 10, 11, 14 and 15 years) practices were chosen to serve as the controls. Soil samples were collected from each of the nine sites at depths ranging from 0 cm to 20 cm and 25 cm to 40 cm. The collected samples were analysed for physico-chemical properties. Soil quality change was estimated by computing percentage equivalence values that define the extent to which mean values of soils under DSI vary from those of the control. The results obtained show that the practices have caused significant negative changes in the levels of most of the properties considered, with significant deleterious effects on the selected physical and chemical indicators of soil quality to extents that might preclude sustainable agriculture on the soils. Potassium, organic carbon, organic matter, and some other essential nutrients needed for plant growth and soil stability have dropped a lot in irrigated farms compared to control farms, but salinization hasn't happened much. It was suggested that the right steps be taken to prevent the loss of important nutrients that crops need to grow well.
Physicochemical Investigation of Some Oil Emulsions Oxidized by UV-B Radiation
Authors: Bakır Temel Kan , Kastrati Hüseyin
Published: January 2023

In this study, the effects of UV B (50 µW/cm2) radiation at 306 nm on oil-in-water emulsions (O/W) using canola oil, soybean oil and linoleic acid were investigated. The oxidation rates of emulsions incubated at pH 7.0 and 37°C in the presence and absence of Cu (II) ions were determined by using iron (III) thiocyanate and thiobarbituric acid methods for the determination of primary and secondary products, respectively. The UV B-induced oxidation rates followed the order LA / Cu (II) > LA > Canola Oil / Cu (II) > Canola Oil > Soybean Oil / Cu (II) > Soybean Oil for both crops. Simultaneously, structural studies were performed using gas chromatography mass spectrometry (GC-MS). It was found that 18-carbon polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid (MUFA) contents have an important role in canola and soybean oil oxidation. The unsaturated fatty acid contents of small carbon numbers increased for each emulsion sample, while the oxidation of fatty acid changes did not follow a regular order.