bluuebunny/crossref_metadata_2025 huggingface dataset:
PRODUK BOARD GAME SEBAGAI MEDIA EDUKASI BERBASIS GAMEBASED LEARNING BIDANG INDUSTRI KREATIF INDONESIA (MITRA: JAGAD CREATIVE)
Authors: Roedavan Rickman , Pudjoatmodjo Bambang
Published: April 2023

Jagad Creative merupakan mitra produktif yang bergerak di bidang desain, dan percetakan. Selama ini fokus utamanya adalah mengerjakan proyek buku dan kalender. Seiring dengan tren perkembangan boardgame, Jagad Creative juga ingin berkontribusi dalam industri boardgame. Namun Jagad Creative belum menguasai teknis pengembangan storytelling, mekanik dan gameflow boardgame. Sehingga tujuan dari pengabdian masyarakat ini adalah untuk membantu Jagad Creative dalam merancang sebuah prototype boardgame. Tema pengembangan boardgame tahap perdana ini adalah pengenalan 16 Subsektor Industri Kreatif. Kegiatan pengabdian kepada masyarakat ini menghasilkan 10 sample boardgame yang masing-masing terdiri dari 1 boardgame, 16 kartu subsektor industri kreatif, 20 kartu organisasi, dan 50 kartu talent kreatif. Implikasi dari kegiatan ini diharapkan Jagad Creative dapat memahami konsep pengembangan gameflow boardgame dan melakukan pencetakan masal terhadap produk boardgame yang diberi nama “Gathering”. Rencana keberlanjutan dari kegiatan ini adalah mengembangkan gameflow boardgame sesuai dengan prototipe gameflow “Gathering” namun menggunakan tema yang berbeda untuk meningkatkan potensi komersialisasi.Kata Kunci: Boardgame, Game-based Learning, Industri Kreatif
PENDAMPINGAN PENGGUNAAN ALAT PEMOTONG SINGKONG OTOMATIS DAN SOSIALISASI K3 DI DESA SUKAPURA
Authors: Caesaron Dino , Salma Sheila Amalia , Prasetio Murman Dwi , Husaini Luthfi Romiz
Published: April 2023

Pekerja merupakan asset utama dalam suatu industri/usaha. Baik itu usaha kecil, menengah, maupun besar. Peran pekerja tidak bisa digantikan serta merta oleh mesin, sehingga Kesehatan dan Keselamatan Kerja mereka perlu dijaga agar tercipata suasana enak, nyaman, aman, sehat, efektif, efisien (ENASE) demi terwujudnya produktivitas yang erat kaitannya dengan output produksi. Desa Sukapura memiliki usaha kecil keripik singkong, yang digawangi oleh Ibu-ibu Pemberdayaan Kesejahteraan Keluarga (PKK). Industri kecil ini dimulai di tahun 2021 awal, dimana saat itu proses pemotongan singkong untuk menjadi keripik menggunakan pemotongan secara manual. Sebelumnya, awal tahun 2022, Fakultas Rekayasa Industri mengadakan kegiatan Pengabdian kepada Masyarakat (PkM) dengan output pengadaan mesin potong singkong otomatis. Dengan adanya mesin ini, kapasitas pemotongan meningkat menjadi kurang lebih 1kg/menit. Pada Pengabdian kepada Masyarakat kali ini, tim yang sama mengadakan pendampingan penggunaan alat, dengan fokus pada optimalisasi penggunaan mesin dan sosialisasi bentuk Kesehatan dan Keselamatan Kerja, diantaranya pengadaan Alat Pelindung Diri (APD) berupa sarung tangan, alat Pertolongan Pertama pada Kecelakaan, dan beberapa petunjuk teknis penggunaan alat. Dari kegiatan kali ini, diharapkan pengguna mesin dapat menyadari pentingnya Kesehatan dan Keselamatan Kerja khususnya saat menggunakan alat tersebut.Kata Kunci: kesehatan dan keselamatan kerja, mesin potong otomatis, alat pelindung diri, pengabdian masyarakat
KEGIATAN PENDAMPINGAN DAN PELATIHAN DIGITAL MARKETING PADA SMK TELKOM MEDAN 1
Authors: Nugrahani Rah Utami , Millanyani Heppy , W.G. Refi Rifaldi
Published: April 2023

Kegiatan Penerimaan Peserta Didik Barua tau bisa disingkat menjadi PPDB menghadapi tantangan tersendiri bagi SMK Telkom Medan 1, hal ini karena selama 2 tahun sejak awal tahun 2020 dihadapkan pada kondisi pembatasan mobilitas yang dikenal dengan nama PSBB atau PPKM. Aktifitas PPDB yang senantiasa dilakukan secara onsite atau tatap muka berubah 360 derajat menjadi dilakukan secara online. Perubahan bentuk kegiatan secara menyeluruh ini menjadi kendala besar bagi seluruh tim PPDB SMK Telkom Medan 1. Berbagai upaya digital marketing dilakukan namun dirasa belum dapat mencapai target secara maksimal. Berangkat dari masalah tersebut maka tim Dosen Faluktas Komunikasi dan Bismis dan Fakultas Ekonomi dan Bisnis Universitas Telkom menawarkan sinergi daam bentuk pemberian pelatihan serta pendampingan Digital Marketing yang bertujuan untuk sharing knowledge mengenai pendekatan yang bisa dilakukan untuk mendorong upaya Digital Marketing lebih maksimal dalam mencapai targetnya.Kata Kunci: digital marketing, PPDB
PELATIHAN DAN PENDAMPINGAN PEMBUATAN KONTEN DAN FOTO PRODUK UNTUK MENINGKATKAN PENJUALAN HASIL HIDROPONIK DI PONDOK PESANTREN MIFTAHUL FALAH
Authors: Ningrum Nina Nursetia , Lionardi Angelia , Rahadianto Irfan Dwi , Mario Mario , Tohir Mohamad , Belasunda Riksa , Saedudin Rd. Rohmat , Almaarif Ahmad , Adityas Adityas
Published: April 2023

Pondok Pesantren Miftahul Falah merupakan pondok pesantren yang berlokasi di Jl. Gedebage Selatan No.115, Kel.Derwati Kec.Rancasari, Bandung, Jawa Barat, menjadi sebuah lembaga resmi yang bernama Yayasan Pendidikan Islam Miftahul Falah. Dalam pengembangannya hingga saat ini, YPI Miftahul Falah telah mendirikan Pondok Pesantren Putra Putri, Majlis Ta’lim, Madrasah Diniyah, Madrasah Ibtidaiyah, Madrasah Tsanawiyah dan Madrasah Aliyah. Pengabdian masyarakat saat ini adalah seri ketiga di Pondok Pesantren Miftahul Falah. Pengabdian masyarakat seri pertama, tim PKM Telkom University telah melakukan kegiatan dengan tema SDGs Pekerjaan Layak dan Pertumbuhan Ekonomi, dimana tim PKM merancang paket bertanam hidroponik di Pesantren Miftahul Falah. Pada pengabdian masyarakat kedua, tim PKM merancang website dan melakukan rebranding pada kemasan produk guna mempromosikan hasil pertanian hidroponik yang dihasilkan sehingga lebih menarik bagi khalayak untuk membeli. Perancangan tersebut memberikan manfaat bagi masyarakat mitra yang dapat membantu meningkatkan pendapatan ekonomi diluar wawasan di lingkungan pesantren. Berdasarkan survei dan wawancara yang dilakukan kepada pengurus, solusi yang paling baik adalah dengan memasarkan hasil tanaman hidroponik dari program pengabdian masyarakat sebelumnya menggunakan media sosial media. Berdasarkan permasalahan di atas, setidaknya ada 2 kegiatan sebagai solusi yangditawarkan dalam bentuk pengabdian masyarakat yang akan dilaksanakan periode 2- 2022 ini yaitu pengembangan dan pembuatan konten sosial media produk hidroponik pesantren dan pelatihan produksi foto produk untuk hidroponik pesantren. Setelah kedua kegiatan tersebut terealisasikan, akan dilakukan evaluasi dan pelaporan untuk mengukur keberhasilan dan tepat sasar guna kegiatan abdimas ini.Kata Kunci: foto produk, hidroponik, konten, pondok pesantren
PEMBEKALAN KETERAMPILAN PEWARNAAN KAIN MENGGUNAKAN PEWARNA ALAMI BAGI ETHICAL FASHION ENTHUSIAST DI KOMUNITAS BIKIN LINGKARAN - BANDUNG
Authors: Puspitasari Citra , Rosandini Morinta , Bastaman Widia Nur Utami
Published: April 2023

Terhitung sejak 2019 yang lalu, tim Pengabdian Masyarakat Program Studi Kriya, Telkom University telah bermitra dengan Komunitas Bikin Lingkaran yang beralamat di Jl. Bahagia Permai III No.38, Margasari, Kec. Buah Batu Kota Bandung Jawa Barat. Program yang diberikan meliputi keterampilan yang berhubungan dengan teknik Kriya Tekstil dan materi Pengembangan Diri. Pada awal tahun 2022, sejalan dengan Peraturan Presiden Nomor 15 Tahun 2018 tentang percepatan pengendalian pencemaran dan kerusakan DAS Citarum serta isu global yang berhubungan dengan dampak pencemaran lingkungan, komunitas Bikin Lingkaran merasa perlu untuk lebih berperan serta mendukung program tersebut. Adanya kecenderungan untuk membahas fashion ramah lingkungan pada tataran anggota Komunitas Bikin Lingkaran khususnya yang memiliki ketertarikan di bidang fashion, menghasilkan kesepakatan untuk menyelenggarakan kegiatan pembekalan keterampilan dengan topik bahasan spesifik yaitu pewarnaan kain menggunakan pewarna alam. Teknik pewarnaan kain meliputi teknik celup dan lukis. Pada akhir kegiatan pembekalan, para peserta menghasilkan lembaran kain berukuran 1 x 1 m² yang memuat dekorasi hasil dari aplikasi teknik ikat celup dan lukis kain.Kata Kunci: Pewarna Alam, Fashion Etis, Ikat Celup
PELATIHAN DAN IMPLEMENTASI SISTEM PEMANTAUAN DAN OTOMASI AQUASCAPE BERBASIS INTERNET OF THINGS DI SMK YASTI CISAAT SUKABUMI
Authors: Irawati Indrarini Dyah , Ramadan Dadan Nur , Hadiyoso Sugondo , Purwanto Yudha , Larasaty Ivosierra Andrea
Published: April 2023

Industri 4.0 mengintegrasikan dunia online dan lini produksi di industri berjalan dengan internet sebagai penopang utama. Platform internet of things (IoT) merupakan salah satu teknologi pendukung revolusi industry 4.0. Teknologi IoT memungkinkan pekerjaan pengukuran dan kendali yang dapat dilakukan melalui jaringan internet. Peguruan Tinggi menjadi semacam tempat persiapan atau pelatihan bagi sumber daya manusia (SDM). Salah satunya dengan memberikan keterampilan yang berkaitan langsung dengan penerapan dan pengembangan aplikasi yang mendukung percepatan industry 4.0. Perguruan tinggi dapat berperan serta memberikan pelatihan kepada jenjang pendidikan di bawahnya. Dalam rangka mendukung program pemerintah tersebut, maka tim pengabdi masyarakat Telkom University aktif menjalin Kerjasama, dalam hal ini dengan SMK Yasti Cisaat Sukabumi. Dengan menyelaraskan kebutuhan dari SMK Yasti sekaligus untuk mendukung program pemerintah, tim pengabdian melanjutkan kegiatan pengabdian masyarakat tahap 2, yang merupakan perwujudan peta jalan pengabdian selama 2 tahun. Pengabdian masayarakat menekankan pada penguatan kompetensi guru dan siswa dalam penguasaan praktik perakitan sensor. Implementasi teknologi tepat guna serta pelatihan sistem pemantauan dan otomasi Aquaspace berbasis IoT dilaksanakan dengan dukungan SMK Yasti Cisaat. Hibah tepat guna yang diberikan terdiri dari perangkat monitoring dan otomasi aquascape, modul pelatihan, video perakitan, serta senso-sensor untuk praktikum di laboratorium. Berdasarkan hasil evaluasi menunjukkan bahwa pengabdian masyarakat ini telah memenuhi dan sesuai kebutuhan di SMK Yasti dengan harapan dapat dilaksanakan secara berkelanjutan.Kata Kunci: aquascape, IoT, otomasi, pelatihan. pemantauan
INDEKS KEPUASAN MASYARAKAT TERHADAP PELAYANAN PERANGKAT DAERAH DI PUSKESMAS RAWAT INAP SAGULING KABUPATEN BANDUNG BARAT Tahun 2021
Authors: Sriharyati Santy , Marlina Milla , Hermawan Irwan , Assegaf Ali
Published: April 2023

Pemerintah wajib bertanggung jawab dalam memberikan fasilitas dan pelayanan yang baik supaya masyarakatnya menjadi sejahtera dan tercukupi segala haknya. Fasilitas publik yang disediakan oleh pemerintah tentunya erat kaitannya dengan pelayanan publik yang akan membantu permasalahan masyarakat Indonesia. Banyak hal yang perlu diperbatikan agar pelayanan publik pada beberapa fasilitas yang dibangun pemerintah terus memberikan yang terbaik bagi masyarakat Indonesia. Pemerintah akan terus mengevaluasi kinerja dari beberapa fasilitas publik agar dapat menjadikan bahan evaluasi kinerja saat ini dengan sebelumnya agar terus memberikan yang terbaik bagi masyarakat. Pengumpulan data secara umum terbagi menjadi dua metode yaitu pengumpulan data primer (wawancara, observasi lapangan dan penyebaran kuesioner) dan data sekunder. Berdasarkan data yang telah diperoleh dalam proses Survei Indeks Kepuasan Masyarakat yang melibatkan 30 responden ini diolah dengan memanfaatkan teknologi pengolahan data yang disesuaikan dengan panduan dari Peraturan Menteri 14 Tahun 2017 yang mengatur tentang Pedoman Penyusunan Survei Kepuasan Masyarakat Unit Penyelenggara Pelayanan Publik supaya bisa mendapatkan hasil yang lebih akurat dibandingkan dengan penghitungan manual. Mayoritas responden yang terlibat dalam wawancara berprofesi sebagai Ibu Rumah Tangga. Mengenai kualitas pelayanan yang diterima oleh responden, dapat ditarik kesimpulan bahwa pelayanan di Puskesmas Saguling sudah terbilang baik dan memenuhi harapan masyarakat. Hanya saja masih terdapat beberapa poin yang masih perlu ditinjau dan dibenahi kembali demi perbaikan pelayanan kedepannya.Kata Kunci: Kepuasan, Pelayanan, Perangkat Daerah, Puskesmas, Bandung Barat, Seminar Nasiona Hasil Pengabdian Kepada Masyarakat The 4th Community Service & Engagemnent Seminar (COSECANT)2022
PELATIHAN DIGITAL MARKETING PEMBUATAN WEBSITE UNTUK RUMAH MAKAN DAN PRODUK LOKAL DI DESA KERTAWANGI SEBAGAI DESA WISATA
Authors: Wulansari Puspita , Yuliandhari Willy Sri , Asalam Ardan Gani
Published: April 2023

Masyarakat Desa Kertawangi secara umum bekerja sebagai petani, namun sejak munculnya pengusaha di bidang kuliner yang diinisiasi dengan adanya tempat wisata di Desa Kertawangi, maka Sebagian besar penduduk Desa kertawangi menambah mata pencaharian mereka dengan bergerak di bidang kuliner. Namun usaha kuliner mereka ini masih terbatas pada pemjualan di tempat-tempat wisata dan dekat rumah mereka, belum memperluas pemasaran mereka dengan menggunakan e-commerce atau secara online. Oleh karena itu, pada kegiatan PKM oleh Tim Dosen dan mahasiswa Universitas Telkom kali ini bertujuan untuk memberikan pelatihan pembuatan website kepada para pelaku rumah makan dan produk lokal warga sehingga mereka bisa memasarkan dan menjual produk kulinernya tidak hanya untuk diwilayah rumah mereka tetapi bisa keluar desa dan lebih luar lagi. Pelatihan ini dimulai dengan melakukan observasi terhadap kebutuhan mereka dalam usaha mereka, dan selanjutnya diberikan pelatihan menggunakan gadget yang mereka miliki. Pelatihan dilakukan pada Hari Jumat tanggal 28 Oktober 2022. Berdasarkan feedback yang dari peserta 98% peserta puas dan merasakan manfaat dari pelatihan yang diberikan, dan berharap dilanjutkan dengan pelatihan lain sehingga mereka dapat meningkatkan pasar mereka. Kata Kunci: Digital Marketing, E-commerce, Pemasaran, Desa wisata, Kuliner
Organizational and Legal Aspects of the Organization of Professional Training of Employees of the Ministry of Internal Affairs of Russia in the System of Additional Professional Education
Authors: Sadekov Rustem Rafekovich , Krokhina Yuliya Valer'evna
Published: April 2023

The authors in their study consider important aspects devoted to the issues of organizational and legal support for the organization of professional training of employees of the internal affairs bodies of the Russian Federation in the conditions of their education in the departmental system of the Ministry of Internal Affairs of Russia. In their work, the authors investigate the current state of affairs, give examples of the organization of the work of the educational and auxiliary units of the university to ensure high-quality training of students as part of their development of various educational programs for advanced training and professional retraining. Attention is drawn to the improvement of legal and organizational approaches to the educational process and increasing the level of competencies of the teaching staff engaged in educational activities within their authority. The tangible contribution of the authors of the presented work is the relevant topic touched upon, due to the fact that at present special importance is attached by the state to improving the level of education, legal culture, professional competence of police officers in the performance of their official duties provided for by federal legislation in this area. The researchers clearly concluded that proper control, planning, legal support of the organization of educational activities of the departmental university of the Ministry of Internal Affairs of Russia in the system of additional professional education, based on the requirements of regulatory legal acts in this area, will certainly allow to regulate the legal relations of all participants in the educational process in a natural way, will increase the level of personal legal responsibility for the implementation of the strategic tasks set by the Ministry of Internal Affairs of Russia.
Transcarotid artery revascularization of a symptomatic carotid artery with a tortuous intrathoracic component
Authors: Gonring Dakota , Wehbe Mohammad Rachad , Stoner Michael , Mix Doran
Published: April 2023

We present the case of a tortuous intrathoracic common carotid artery (CCA) with a symptomatic right internal carotid artery lesion. This patient had a complex medical history, including a previous intraoperative cardiac arrest during attempted carotid endarterectomy (CEA) initially attributed to heparin anaphylaxis. She received maximum medical management but presented 6 months later to our institution with a secondary transient ischemic attack. Surgical options for the case were discussed amongst a multidisciplinary team. Transfemoral and transradial stenting were deemed non-viable due to the tortuous nature of the CCA. Repeat CEA under general anesthesia was deemed risk-prohibitive from a cardiac risk perspective. For these reasons, the patient was offered transcarotid artery revascularization (TCAR) under regional anesthesia. Intraoperatively, the “sheath stopper” was removed from the TCAR device, allowing the sheath to be advanced to 6 cm, effectively removing the tortuous component of the CCA. Flow reversal was established, and the operation proceeded in the standard fashion without neurologic change. The patient has remained on dual antiplatelet therapy and completed 2-year follow-up without evidence of restenosis, access site complication, or repeat neurologic event. This case demonstrates the potential applicability of TCAR to benefit a subset of patients who previously lacked a surgical option due to anatomical constraints.
Simultaneous bilateral quadriceps tendon rupture in a patient on hemodialysis: A case report
Authors: Utkarsh Srijan , Manral Sushma , Nischal Neha
Published: April 2023

Simultaneous bilateral quadriceps tendon rupture is an uncommon but disabling clinical entity that usually has an underlying cause of tendon weakening. We present a case of a 36-year-old male who presented with full-thickness tears of both quadriceps tendons following a fall on the knees and was found to have underlying calcific tendinopathy secondary to chronic kidney disease and hemodialysis. Imaging with radiographs and ultrasound scans usually suffices for the evaluation of tendon pathology in cases of clinical suspicion of quadriceps tendon rupture.
Unusual presentation of subcapsular renal pseudocyst as page kidney – A case report
Authors: Thakur Shruti , Kapila Sumala , Makhaik Sushma , Jhobta Anupam
Published: April 2023

Page kidney is a rare but potentially curable cause of secondary hypertension. While the pancreatic pseudocyst is a completely different and unrelated entity. Here, we report a case of a 45-year-old female, diagnosed with idiopathic acute pancreatitis with multiple pseudocysts. After successful ultrasound -guided drainage of her left subcapsular renal pseudocyst, she became normotensive again, confirming the diagnosis of page kidney. This case highlights dual reasons that prompted us to report the case. The first being such remotely located subcapsular renal pseudocyst as itself a rare entity and the second, its unusual presentation as page kidney. The case emphasizes on the early management of such patients so as to salvage renal function.
A rare cause of hemoperitoneum – Gynecological emergency
Authors: Jayanthan S. Shanmuga , Rupesh G. , Devipriya T. , Nadanasadharam K.
Published: April 2023

Uterine fibroids are common benign smooth muscle tumors, at times may present with acute life-threatening complications. Spontaneous hemorrhage from a uterine fibroid is extremely rare but do occur. Herein, we report a case of a 36-year-old woman with acute onset of abdominal pain and diagnosed with hemoperitoneum for which emergency laparotomy was performed.
Labor Absorption in Agribusiness of Patchouli Plant in Benua Village, Konawe Selatan
Authors: Rosmayani Rosmayani , Rianse Ilma Sarimustaqyima , Sadimantara Fahria Nadiryati
Published: April 2023

The aim of this study is to understand the role of patchouli agribusiness in the absorption of employment in Benua Villages, Benua districts, South Konawe regency. These research was carried out in continent village, Continent District, South Konawe Regency. The population in this study were, namely agribusiness in Benua villages that do patchouli farming, patchouli oil business, and workers totaling 35 people, with a sample of 35 people because all the population was sampled. The variables in this study are the identity of the respondents including: farmer's age, level of education, patchouli management experience, and the number of family dependents. The results of this study showed that the cultivation of patchouli, patchouli oil, and labor has employment absorption of 20%
Adaptive Language Model Training for Molecular Design
Authors: Blanchard Andrew , Bhowmik Debsindhu , Fox Zachary , Gounley John , Glaser Jens , Akpa Belinda S , Irle Stephan
Published: April 2023

The vast size of chemical space necessitates computational approaches to automate and accelerate the design of molecular sequences to guide experimental efforts for drug discovery. Genetic algorithms provide a useful framework to incrementally generate molecules by applying mutations to known chemical structures. Recently, masked language models have been applied to automate the mutation process by leveraging large compound libraries to learn commonly occurring chemical sequences (i.e., using tokenization) and predict rearrangements (i.e., using mask prediction). Here, we consider how language models can be adapted to improve molecule generation for different optimization tasks. We use two different generation strategies for comparison, fixed and adaptive. The fixed strategy uses a pre-trained model to generate mutations; the adaptive strategy trains the language model on each new generation of molecules selected for target properties during optimization. Our results show that the adaptive strategy allows the language model to more closely fit the distribution of molecules in the population. Therefore, for enhanced fitness optimization, we suggest the use of the fixed strategy during an initial phase followed by the use of the adaptive strategy. We demonstrate the impact of adaptive training by searching for molecules that optimize both heuristic metrics, drug-likeness and synthesizability, as well as predicted protein binding affinity from a surrogate model. Our results show that the adaptive strategy provides a significant improvement in fitness optimization compared to the fixed pre-trained model, empowering the application of language models to molecular design tasks
Quantitative benchtop 19F NMR spectroscopy: a robust and economical tool for rapid reaction optimization
Authors: Heinrich Gregor , Kondratiuk Mykhailo , Gooßen Lukas J. , Wiesenfeldt Mario P.
Published: April 2023

The instrumental analysis of reaction mixtures is usually the rate-determining step in the optimization of chemical processes. Traditionally, reactions are analyzed by gas chromatography (GC), high-performance liquid chromatography (HPLC), or quantitative nuclear magnetic resonance (qNMR) spectroscopy on high-field spectrometers. However, chromatographic methods require elaborate work-up and calibration protocols, while high-field NMR spectrometers are expensive to purchase and operate. We herein disclose an inexpensive and highly effective analysis method based on low-field benchtop-NMR spectroscopy. Its key feature is the use of fluorine-labeled model substrates which, due to the wide chemical shift range and high sensitivity of 19F, enables separate, quantitative detection of product and by-product signals even on low-field, permanent magnet spectrometers. An external lock / shim device obviates the need for deuterated solvents, permitting the direct, non-invasive measurement of crude reaction mixtures with minimal work-up. The low field-strength allows a homogeneous excitation over a wide chemical shift range, minimizing systematic integration errors. The addition of the correct amount of the non-shifting relaxation agent Fe(acac)3 minimizes relaxation delays at full resolution, reducing the analysis time to 32 seconds per sample. The correct choice of processing parameters is also crucial. A step-by-step guideline is provided, the influence of all parameters is discussed, and potential pitfalls are highlighted. The wide applicability of the analytical protocol for reaction optimization is illustrated by three examples: a Buchwald-Hartwig amination, a Suzuki coupling, and a C–H functionalization reaction.
Development of a Natural Product Optimization Strategy for inhibitors against the cell wall synthesis enzyme MraY, a promising antibacterial target
Authors: Yamamoto Kazuki , Sato Toyotaka , Hao Aili , Asao Kenta , Kaguchi Rintaro , Kusaka Shintaro , Raju Ruddarraju Radhakrishnam , Kazamori Daichi , Seo Kiki , Takahashi Satoshi , Horiuchi Motohiro , Yokota Shin-ichi , Lee Seok-Yong , Ichikawa Satochi
Published: April 2023

Optimization of natural products is often required to improve their drug-like properties for therapeutic use. However, chemical modifications of natural products are painstaking tasks due to complex synthetic processes, which is a bottleneck in advancing natural products to clinic. Here, we developed a strategy for a comprehensive in situ evaluation of the build-up library, which enables us to streamline the preparation of the analogue library and directly assess its biological activities. We applied this approach to a series of natural product inhibitors for MraY, an important target for the antibacterial development. Through construction and evaluation of the 686-compound library, we identified promising analogues that exhibit potent and broad-spectrum antibacterial activity against highly drug-resistant strains in vitro as well as in vivo in an acute thigh infection model Structures of the MraY-analogue complexes reveal distinct interaction patterns, suggesting that these analogues represent new types of MraY inhibitors with unique pharmacological profiles.
Catalyst or Catalyst System? Nonlinear Behaviour and the Limits of Mechanistic Understanding in Proline-Based Asymmetric Catalysis.
Authors: THIERRY Thibault , GEIGER Yannick , BELLEMIN-LAPONNAZ Stephane
Published: April 2023

Asymmetric catalysis has expanded the range of chiral products readily accessible through increasingly efficient synthetic catalysts. The development of these catalysts often starts with a result obtained by systematic screening of known privileged chiral structures and is based on the assumption that the active species would be an isolated monomolecular species. Here, we have studied the activity of three proline-derived ligands that differ in minor chemical modifications. In the zinc-catalysed alkylation of benzaldehyde, we found that they exhibit completely different systems-level behaviours, characterized by multiple aggregation levels that are catalytically active simultaneously. Notably, we were able to establish the possibility of at least trimeric active species in equilibrium with less aggregated active species. These results were obtained through a combination of nonlinear effect studies and other related studies such as product ee versus catalyst loading and temperature as well as in situ NMR studies. Simulations using a mathematical model have confirmed the possibility of such systems-level behaviour. This indicates that the chiral structure alone does not necessarily correlate with systems-level behaviour that could alter the outcome of a given catalytic reaction.
Forms of address and (im)politeness: a corpus-assisted study of Polish professional and non-professional subtitles
Authors: Bączkowska Anna
Published: April 2023

The aim of the study is to analyse how the English form of address you is translated into Polish in subtitles. The investigation is embedded in the framework of (im)politeness theory. The data used for the study comprise two types of non-professional renderings: amateur subtitles (fansubbing) and subtitles written by sophomore students of English Philology. The study proves that fansubbers’ subtitles have a tendency to foreignise translation by ignoring the Polish sociocultural norms of terms of address, thus making it sound less polite and marked, while students’ translations show a tendency to make the original dialogue more familiar to the target (secondary) audience, and make it more acceptable and polite.
Festival Sebagai Bentuk Sosialisasi Terhadap Kontinuitas Eksistensi Tari Galombang Duo Baleh di Nagari Sintuak Padang Pariaman
Authors: Dhari Belirda Wulan , Sari Ayuthia Mayang
Published: April 2023

This article was purposed to reveal the urgency of dance festival and exhibition socialization toward the continuity of Tari Galombang Duo Baleh in community of Nagari Sintuak [village]. Tari Galombang Duo Baleh was a tradition that borne and grew in Nagari Sintuak Padang Pariaman. Tari Galombang Duo Baleh was one of cultural heritage in community of Nagari Sintuak. Lately, Tari Galombang Duo Baleh was coped an existence problem, one of degradation factors was lack of publication or lack of appreciation from community toward Tari Galombang Duo Baleh. In this article, writer offered one of the ways to promote the existence of Tari Galombang Duo Baleh to community of Nagari Sintuak. In turn, dance festival and socialization had an effect to the continuity of Tari Galombang Duo Baleh existence in community of Nagari Sintuak Padang Pariaman. Keywords: ata kunci: Galombang Duo Baleh Dance; Existence; Festival;  Socialization AbstrakArtikel ini bertujuan menjelaskan tentang pentingnya festival tari dan sosialisasi pertunjukan untuk mempertahankan keberlanjutan keberadaan tari Galombang Duo Baleh dalam masyarakat Nagari Sintuak. Tari Galombang Duo Baleh adalah tari tradisi yang lahir, hidup dan berkembang di Nagari Sintuak Padang Pariaman. Tari Galombang Duo Baleh merupakan salah satu warisan budaya masyarakat Nagari Sintuak. Dewasa ini, keberadaan tari Galombang Duo Baleh mengalami problematika eksistensi, salah satu faktor degradasi eksistensi diduga adalah kurangnya publikasi, atau kurangnya apresiasi masyarakat terhadap tari Galombang Duo Baleh  tersebut. Dalam artikel ini penulis menawar kan salah satu jalan untuk Re-eksistensi adalah melalui festival atau parade tari dan sosialisasi pertunjukan tari Galombang Duo Baleh kepada masyarakat Nagari sintuak. Pada gilirannya, festival dan sosialisasi berdampak pada kontinuitas eksistensi tari Galombang Duo Baleh dalam masyarakat Nagari Sintuak Padang PariamanKata Kunci: Tari Galombang Duo Baleh; Eksistensi; Festival; Sosialisasi
ASSESSMENT OF THE SANITARY CONDITION OF BIRCH STANDS IN FOREST PARKS OF THE CITY OF TYUMEN (ON THE EXAMPLE OF THE ZATYUMENSKY ECOPARK)
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Dancheva A. V. , Zalesov S. V. , Nazarova V. V. , Elshanavani E. E. , Vaganova A. A.
Published: April 2023

The results of a study of the state of birch tree stands of the «Zatyumensky» ecopark are presented using indicators of sanitary condition, relative living condition, relative height and a comprehensive assessment indicator. It is established that according to the indicators of sanitary and relative living condition, birch stands in all test areas are characterized as weakened. There is a general pattern of increasing the number of severely weakened and drying trees and decreasing the number of healthy trees with an increase in recreational impact. In the area of active visitation, the number of severely weakened and dying trees is 2-9 times greater, and the number of healthy trees on average is 3-4 times less in comparison with the zones of moderate and weak visits. The number of dead trees decreases by 2-5 times as the tree stand is removed from the object of linear recreation. The analysis of the types of damage to birch tree trunks showed that the most common are mechanical damage to tree trunks and the presence of fruit bodies on tree trunks. The largest number of trees with mechanical damage is noted in the area of active visitation – up to 14% of the total number of trees, which is 4-8 times higher than the same indicator in the zone of moderate and weak visits. The largest number of trees with fruit bodies on the trunks is noted in the area of weak visits – up to 7% of the total number of recorded trees. The largest number of trees with fruit bodies on the trunks is noted in the area of weak visits – up to 7% of the total number of recorded trees. In order to prevent the degradation of birch plantations of the «Zatyumensky» ecopark and increase their sustainability, a number of forestry measures have been proposed, in particular, temporary fencing of forest areas that are in critical condition for the period of their restoration; carrying out landscape felling in order to rejuvenate tree stands and create recreationally attractive and sustainable landscapes of semi-open type, etc.
PROBLEMS AND WAYS FOR SOLVING ISSUES OF ENGINEERING PROTECTION AND RESTORATION OF COASTAL DISTURBED LANDS OF URBAN TERRITORIES
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Kurbanov S. O. , Khanov N. V. , Chernykh O. N.
Published: April 2023

The problems of engineering protection of territories from flooding and flooding by flood waters of rivers are relevant for many regions of Russia, including for the Moscow region, where the project of creating the science town «Big Serpukhov» is being implemented. At the same time, serious obstacles arose related to the flooding of a significant part of the territories of the coastal zones of the Serpukhov region. Here, most of the agricultural land is in a disturbed and degraded state, it needs to be restored using phytomeliorative measures. In order to solve the problems and obstacles that have arisen, scientific programs have been drawn up to study and survey the existing state of all territories and objects of the science city being formed. And also – water bodies (Oka and Nara rivers), which are sources of flooding of coastal areas and settlements. The results of the analysis of materials previously made by the authors of developments and inventions on the engineering protection of coastal territories and objects are presented from the point of view of the possibility of their use in solving the problems of fl ooding the lands of the science city. The developments and inventions that can be effectively used in solving the issues of engineering protection and environmental arrangement of the flooded territories of the science city are briefly demonstrated. The results of preliminary studies confirm the high efficiency and manufacturability of the use of bioengineering systems for the protection and development of coastal zones. The creation and implementation of bioengineering systems based on natural and safe artifi cial materials will reduce the material costs of construction and will contribute to the restoration of water protection and other disturbed zones in compliance with environmental requirements. A preliminary assessment of the impact of the dam on the Nara River in a hydrodynamic accident on the parameters of the fl ood zone in the left-bank part of the clusters and districts of Serpukhov showed that in the implementation of the most likely accident scenario, the emergency situation may be local in terms of material damage and municipal in terms of territoriality.
Sociologia Digital: o fenômeno metaverso
Authors: Macedo Valéria
Published: April 2023

Este estudo apresenta uma abordagem descritiva sobre tecnologias emergentes que estão possibilitando a construção de novos ambientes digitais de interações dos indivíduos tornando-se necessário a investigação com base na sociologia digital. Aborda-se primeiramente como as plataformas digitais passaram a fazer parte da rotina dos indivíduos, principalmente das redes sociais, possibilitando a vida atual em uma sociedade de plataforma. O metaverso como uma extensão desse ambiente é apresentado por meio de conceitos e definições ainda em construção pela acadêmica, mas que traz potenciais para a migração dos indivíduos para ambientes e plataformas descentralizadas. Conclui-se que é fundamental o monitoramento deste fenômeno chamado metaverso no campo das ciências sociais. As investigações sociais neste ambiente podem contribuir para compreender o impacto no comportamento em um mundo cada vez mais figital (físico + digital) do ser humano em sociedade.
Profissionais tradicionais de saúde e suas estratégias populares no combate a sinais e sintomas de doenças em Santarém-PA
Authors: Silva da Costa Teógenes Luiz , ACIOLY FERNANDES PAOLA MARCÉLIA
Published: April 2023

A Amazônia é um emaranhado de formas de viver, com diferentes sistemas de identidade, tradições e memórias. Apresentamos reflexões iniciais sobre sujeitos que detêm saberes e práticas tradicionais em saúde na região amazônica, especificamente aqueles naturais do município de Santarém, Pará. Refletimos sobre a continuidade e (re)existência de saberes não biomédicos possibilitados por Profissionais Tradicionais de Saúde (PTS) que mantêm vivo um conjunto de estratégias populares para o combate de sinais e sintomas de doenças. Também investigamos em quais espaços se encontram os PTS e quais funções sociais exercem em suas comunidades. Usamos a pesquisa exploratória, pois caracteriza-se enquanto um estudo preliminar para a familiarização com o tema investigado. Foi dividido em quatro etapas, sendo a etapa final a entrevistas com onze profissionais tradicionais de saúde realizadas entre outubro de 2018 a abril de 2019 na cidade de Santarém, PA. Tais profissionais se diferenciam dos profissionais de saúde porque usam em maior medida a escuta em seus processos, pois entendem a integralidade de seus pacientes. Todavia, ainda existe muito estigma com relação ao conhecimento desses profissionais e que esta pode ser, apesar de embrionária, uma iniciativa capaz de aproximar o conhecimento científico da comunidade acadêmica ao conhecimento empírico desses curadores.
Like/dislike como metacódigo moral e acelerador social
Authors: Luz Costa Antônio
Published: April 2023

O tema deste artigo é a influência de orientações binárias produzidas por algoritmos no comportamento social. O objetivo é evidenciar os efeitos sociais amplos que a introdução e estabilização de uma diferença pode produzir. A diferença aqui tomada como exemplo é a entre gostar/não gostar, ou like/dislike. O procedimento metodológico é orientado pela análise de problemas sobre o tema evidenciados em outras pesquisas com o auxílio de conceitos de moral e tempo da teoria dos sistema sociais de Niklas Luhmann. O resultado do trabalho conduz ao entendimento de que a diferenciação entre like/dislike, em suas diversas formas, tornou-se um metacódigo moral e provoca uma aceleração social.
Redes sociais num mundo em mudança acelerada
Authors: Fialho Joaquim Fialho , Macedo Valéria , Dias Elaine , Thurler Larriza
Published: April 2023

O mundo vive um processo de mudança acelerada. O local tornou-se global. O global tornou-se uma rede. Entender as mudanças e planejar o futuro é, hoje, um enorme desafio das Ciências Sociais. Este artigo apresenta uma síntese dos contributos multidisciplinares de vários autores que têm se dedicado ao estudo das redes sociais e a forma comoelas influenciam ou condicionam diversos ecossistemas presenciais ou digitais.
MARKETING AND CHALLENGES FOR THE COVID 19 VACCINE IN UTTARAKHAND
Authors: Ragaur Sandhya
Published: April 2023

Background: The first case in Uttarakhand was recorded on March 15, 2020, and the total positivity rating was 17.5 on May 22, 2020. Given that Vaccination was the only “foolproof” way to fight against COVID-19, the inoculation of the population was necessary to revitalize the economy, protect its citizens and take a step closer to defeating the pandemic. Thus, Vaccine Drives were heavily incentivized and marketed to the general population.Methods: In this research paper, the marketing, and challenges of vaccination in Uttarakhand have been analysed by collecting primary data through questionnaires and secondary data through research papers, articles, official government websites and newspapersFindings: The Uttarakhand government employed various strategies to vaccinate the general public. They provided non-monetary incentives, appointed vaccine ambassadors, provided for workplace vaccinations and associated with private offices to run vaccine programs. These were met with certain barriers caused mainly due to the demographic factors such as nature of locality (rural/ urban), gender, etc. and vaccination shortage.Conclusion: The programs of the Uttarakhand Government were met with mostly satisfactory responses. The problems causing barriers to vaccination have mostly straightforward answers which have to be implemented through long-term plans such as providing technical skills, better accessibility in rural regions and education to be scientifically aware among the general populace.
A Study Uses and Tea Brewing Method of Tea Utensils Found in the Underground Relic of Tang Dynasty Beop-Moon Temple
Authors:   The Korean Tea Society, Lee Ju-Hyeon
Published: April 2023

Department of Korean Tea Culture, Gyeongsang National University, Gyeongnam 52725, Korea Abstract The differences in opinion between Korean and Chinese researchers on the uses of tea utensils found in the underground relic of Beop-Moon Temple motivated this study. They perceived the use of same object found in the underground relic in different ways. Books, academic papers, and dissertations newly published in China were referenced as a methodology for the specification of the problem since literature data and related research results in Korea are lacking. The results showed that Yukeumeunkuhaband Yukeum-inmulhwaeundamja not tea utensil, but fragrance utensil. And during this period, the royal family's brewing method was in a transitional period developing from Jeon-cha method to Jeom-cha method. The tea utensils excavated from Beop-Moon Temple were used in the tea drinking method, in which powdered tea is put in and then burnt with a spoon. This study intended to recognizes the problems and necessity of research on the use of tea utensils found in underground relic, and based on the research data, to approach tea utensil found in Beop-Moon Temple, which is a standard at that time, more objectively.
Infusion Characteristics of Major Components at Different Water Temperature and Time in Jeju Green Teas
Authors:   The Korean Tea Society, Oh Eun Ui , Park Hyung Wook , Oh Young Min , Song Kwan Jung
Published: April 2023

The taste of green tea is determined by interaction of brewed components. The characteristics of components in infusion are related to components content of green teas and their infusion rate. This study aimed to evaluate the quality of green teas manufactured with different methods in Jeju and analyze the infusion property of major components related to water temperature and time. Green teas including fan-fired, roasted and steamed ones were evaluated to be high-qualified with 4.5-6.0% of amino acids and around 2.5%. As brewing water temperature (70℃, 80℃, 90℃ and 100℃) rose and brewing time (1 min, 2 min and 4 min) increased, the infusion levels of most components were high. There was no difference in infusion rate of caffeine, but distinct differences were observed in infusion rate of the other components by green tea manufacturing method. The results indicated that proper infusion conditions could be at 70-80℃ and for less than 2 min regardless of green tea manufacturing methods considering taste.
Manual de Elaboração do Artigo Científico
Authors: Silva Franco Pereira
Published: April 2023

O Manual de Elaboração do Artigo Científico da Faculdade de Anicuns é uma ferramenta elaborada para a orientação dos estudantes na elaboração do Trabalho de Conclusão de Curso, considerando as regras da ABNT e as normas próprias da instituição. O objetivo principal do manual é oferecer uma orientação clara e objetiva sobre as etapas necessárias para a elaboração de um artigo científico.
Uma das principais vantagens do manual é que ele foi pensado para atender às necessidades dos alunos e pesquisadores da Faculdade de Anicuns, considerando as particularidades das áreas de conhecimento estudadas na instituição. Além disso, o manual apresenta exemplos práticos e ilustrações que ajudam a compreender melhor as orientações e a aplicá-las de forma adequada.
A psychiatric clinical picture revealing moyamoya disease
Authors: Stati Soukaina , Baba Mohamed Amine , Kharbach Ahmed , Achbani Abderrahmane , Bigi Soufiane , Asma Boukdir , Belbachir Siham , Ouanass Abderrazzak
Published: April 2023

Moyamoya disease (MMD) is a rare entity. It is a chronic cerebrovascular pathology characterized by stenosis and progressive occlusion of the termination of the carotid arteries. It is of reserved prognosis. Its diagnosis can be evoked on computerized tomography and magnetic resonance imaging (MRI) but is essentially based on arteriography. Its treatment must be early and essentially consists of revascularization surgery. We report the case of a patient admitted to the psychiatric emergency room for management of a behavioral disorder, mutism and auditory and visual hallucination, a cerebral MRI was performed urgently and the diagnosis of MMD was laid. Through this observation and a review of the literature, we discuss the characteristics of this rare condition, in particular the psychiatric comorbidity.
Effect of newly detected hyperglycemia on the course of coronary heart disease
Authors: Chernus Natalya , Granma Konni
Published: April 2023

Mechanisms and causes of hyperglycemia (HG) during coronary heart disease (CHD), particularly in its unstable forms, remain not fully investigated. The study aimed to determine the effect of newly detected HG on the course of CHD and examine the features of carbohydrate metabolism in patients with CHD. The study was conducted in Moscow (Russia) in 2018-2021. A total of 139 patients with CHD aged 43 to 79 years were examined. All participants were divided into comparison groups, including 34 patients with average glucose levels, 28 patients with fasting HG, 46 patients with impaired glucose tolerance (IGT), and 31 patients with newly diagnosed type 2 diabetes. The range of laboratory examinations included general clinical tests of blood and urine, determination of blood urea, creatinine, C-reactive protein, bilirubin and its fractions, the activity of hepatic transaminases, the study of carbohydrate metabolism, lipidogram, ionogram, and coagulogram. First-time diagnosed HG was a fairly frequent diagnosis in CHD patients (in 105 (75.5%) of 139 patients examined). IGT and type 2 diabetes mellitus recently detected in CHD patients have common disease-causing factors: insulin resistance, lipid metabolism disorders, and sympathetic nervous system activation against the background of reduced parasympathetic effects. All of this should be considered in developing treatment regimens for CHD patients and controlling risk factors.
New records on Fomitiporia and Fuscoporia (Hymenochaetaceae) in areas of the Atlantic Forest in Northeastern Brazil
Authors: Targino de Oliveira Virton Rodrigo , Baptista Gibertoni Tatiana
Published: April 2023

During collections carried out in the Atlantic Forest in Northeastern Brazil, specimens belonging to Fomitiporia and Fuscoporia were collected. The morphological and molecular analyses of ITS and nLSU regions confirmed that they represent Fomitiporia conyana, Fo. maxonii, Fo. neotropica, Fuscoporia atlantica, Fu. formosana, Fu. licnoides and Fu. scruposa, some of them new records for areas of Atlantic Forest in Brazil as well as for the states of Alagoas, Bahia and Pernambuco.