bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of a MS Based Proteomics Method for Milk and Egg Quantification in Cookies at the Lowest VITAL Levels: An Alternative to the Use of Precautionary Labeling
Authors: Monaci Linda , De Angelis Elisabetta , Guagnano Rocco , Ganci Aristide P. , Garaguso Ignazio , Fiocchi Alessandro , Pilolli Rosa
Published: October 2020

The prevalence of food allergy has increased over the last decades and consequently the food labeling policies have improved over the time in different countries to regulate allergen presence in foods. In particular, Reg 1169 in EU mandates the labelling of 14 allergens whenever intentionally added to foods, but the inadvertent contamination by allergens still remains an uncovered topic. In order to warn consumers on the risk of cross-contamination occurring in certain categories of foods, a precautionary allergen labelling system has been put in place by food industries on a voluntary basis. In order to reduce the overuse of precautionary allergen labelling (PAL), reference doses and action limits have been proposed by the Voluntary Incidental Trace Allergen Labelling VITAL project representing a guide in this jeopardizing scenario. Development of sensitive and reliable mass spectrometry methods are therefore of paramount importance in this regard to check the contamination levels in foods. In this paper we describe the development of a time-managed multiple reaction monitoring (MRM) method based on a triple quadrupole platform for milk and egg quantification in processed food. The method was in house validated and allowed to achieve levels of proteins lower than 0.2 mg of total milk and egg proteins, respectively, in cookies, challenging the doses recommended by VITAL. The method was finally applied to cookies labeled as milk and egg-free. This method could represent, in perspective, a promising tool to be implemented along the food chain to detect even tiny amounts of allergens contaminating food commodities.
A Cellular Automata Approach for the Modeling of a Polyamide and Carbon Aerogel Structure and Its Properties
Authors: Menshutina Natalia , Lebedev Igor , Lebedev Evgeniy , Paraskevopoulou Patrina , Chriti Despoina , Mitrofanov Igor
Published: October 2020

In this work, a cellular automata (CA) approach was used to generate 3D structures of polyamide and carbon aerogels. Experimental results are used as initial data for materials’ digital representations and to verify the developed CA models. Based on the generated digital structures, a computer study of aerogels’ mechanical properties was conducted. The offered CA models can be applied for the development of new nanoporous materials such as aerogels of different nature and allow for a reduction in the amount of required full-scale experiments, consequently decreasing development time and costs of new material formulations.
QTL Mapping for Domestication-Related Characteristics in Field Cress (Lepidium campestre)—A Novel Oil Crop for the Subarctic Region
Authors: Hammenhag Cecilia , Saripella Ganapathi Varma , Ortiz Rodomiro , Geleta Mulatu
Published: October 2020

Domestication of a new crop requires identification and improvement of desirable characteristics Field cress (Lepidium campestre) is being domesticated as a new oilseed crop, particularly for northern temperate regions.. In the present study, an F2 mapping population and its F3 progenies were used to identify quantitative trait loci (QTLs) for plant height (PH), number of stems per plant (NS), stem growth orientation (SO), flowering habit (FH), earliness (ER), seed yield per plant (SY), pod shattering resistance (SHR), and perenniality (PE). A highly significant correlation (p < 0.001) was observed between several pairs of characteristics, including SY and ER (negative) or ER and PE (positive). The inclusive composite interval mapping approach was used for QTL mapping using 2330 single nucleotide polymorphism (SNP) markers mapped across the eight field cress linkage groups. Nine QTLs were identified with NS, PH, SO, and PE having 3, 3, 2, and 1 QTLs, explaining 21.3%, 29.5%, 3.8%, and 7.2% of the phenotypic variation, respectively. Candidate genes behind three of the QTLs and favorable marker alleles for different classes of each characteristic were identified. Following their validation through further study, the identified QTLs and associated favorable marker alleles can be used in marker-aided breeding to speed up the domestication of field cress.
DNA Damage and Repair in Pulmonary Arterial Hypertension
Authors: Sharma Samantha , Aldred Micheala A.
Published: October 2020

Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with both genetic and environmental dynamics contributing to disease progression. Over the last decade, several studies have demonstrated the presence of genomic instability and increased levels of DNA damage in PAH lung vascular cells, which contribute to their pathogenic apoptosis-resistant and proliferating characteristics. In addition, the dysregulated DNA damage response pathways have been indicated as causal factors for the presence of persistent DNA damage. To understand the significant implications of DNA damage and repair in PAH pathogenesis, the current review summarizes the recent advances made in this field. This includes an overview of the observed DNA damage in the nuclear and mitochondrial genome of PAH patients. Next, the irregularities observed in various DNA damage response pathways and their role in accumulating DNA damage, escaping apoptosis, and proliferation under a DNA damaging environment are discussed. Although the current literature establishes the pertinence of DNA damage in PAH, additional studies are required to understand the temporal sequence of the above-mentioned events. Further, an exploration of different types of DNA damage in conjunction with associated impaired DNA damage response in PAH will potentially stimulate early diagnosis of the disease and development of novel therapeutic strategies.
Developing a Rock Garden at Edith J. Carrier Arboretum, Harrisonburg VA (U.S.A.) as a Resource for Promoting Geotourism
Authors: Elmi Chiara , Simal Amanda G. , Winchester Gregory P.
Published: October 2020

Virginia is a state in the Southeastern and Mid-Atlantic regions of the United States of America that offers spectacular sceneries and varied geologic history that covers about 1.5 billion years. A rock garden was developed at the Edith J. Carrier Arboretum in Harrisonburg, VA. The rock garden at the Edith J. Carrier Arboretum is a place where rocks look as they did when they were part of an outcrop on the side of a mountain or a creek in the Shenandoah National Park. Rock slabs were collected along the existing trails of the Arboretum and classified based on the mineralogy and physiographic province. The rock garden offers a place to observe Earth materials from Virginia without potentially travelling long distances. The goal is to educate the community on the local resources and promote sustainable geotourism. This paper illustrates a method for rapid and accurate quantitative mineralogical analysis of complex mixtures using X-ray powder diffraction. Correctly classifying a fine-grained sample such as a sedimentary rock using primarily the identification of minerals in a thin section or in hand specimens could not be accurate; thus, X-ray diffraction was used to confirm hand sample analyses. The samples are mostly sedimentary rocks from the Appalachian Mountains. Three different lithological types (dolostone, limestone, and shale) play the most important role in the geological context of the Rockingham county. The mineralogical features shown in this paper provide a detailed picture of the geological significance of the resources that shape the Appalachian Mountains in the Shenandoah National Park.
Psychometric Properties of the Health Professionals Communication Skills Scale in University Students of Health Sciences
Authors: Juliá-Sanchis Rocío , Cabañero-Martínez María José , Leal-Costa César , Fernández-Alcántara Manuel , Escribano Silvia
Published: October 2020

Communication is one of the determining factors of healthcare quality; however, a health model that prioritizes clinical over non-technical skills remains prevalent. The aims of this article were: (a) to validate a communication skills scale in a sample of fourth-year nursing degree students from two Spanish universities and (b) determine their perception of communication skills. The study included 289 fourth-year nursing undergraduate students with a mean age of 22.7 (SD = 4.87) years; 81.7% were female. The Health Professionals Communication Skills Scale (HP-CSS) questionnaire was adapted for use among nursing students. We analysed the psychometric properties and relationships with the variable attitudes toward communication skills. The HP-CSS showed a high internal consistency (0.88) and good fit of data to the model (TLI = 0.98; CFI = 0.97; RMSEA = 0.05 [95% CI = 0.04–0.06]). The total score and subscale scores correlated with the variable attitude towards communication skills. High scores were obtained for the students’ perception of communication skills. The HP-CSS is a valid and reliable tool to assess the communication skills in nursing students. This scale provides university teachers with a rapid and easily applied instrument to assess the level of communication skills and relationship with patients.
The Design, Content and Delivery of Relationship and Sexuality Education Programmes for People with Intellectual Disabilities: A Systematic Review of the International Evidence
Authors: Brown Michael , McCann Edward , Truesdale Maria , Linden Mark , Marsh Lynne
Published: October 2020

There is growing empirical evidence regarding the relationship and sexuality experiences and needs of children, young people and adults with intellectual disabilities. A total of twelve papers met the inclusion criteria regarding relationship and sexuality education (RSE) programmes specific to the needs of this population. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed and quality appraisal undertaken. The four themes identified were principles informing RSE programme development, design and content of RSE programmes, delivery of RSE programmes and evaluation of RSE programmes. The discussion presents areas that need to be addressed to ensure that people with intellectual disabilities, their families, carers and professionals are fully involved in the design and delivery of RSE programmes. Further research is required to identify the impact of the programmes and the sustained outcomes achieved. Recommendations are made regarding the activities required to enable the development of evidence-based and person-centred approaches to relationship and sexuality programmes.
Body Expression-Based Intervention Programs for Persons with Intellectual Disabilities: A Systematic Review
Authors: Lirola María-Jesús , Ruiz-Rico Gerardo , Hernández-Rodríguez Antonia-Irene , Prados-Megías María-Esther
Published: October 2020

The benefits of physical exercise on human health are widely known. However, the level of physical activity in the majority of the population is considered insufficient. People with intellectual disabilities (ID), in particular, show this lack of physical activity to a greater extent. It has been noted that the promotion of activities focused on corporal expression (CE) stimulates the motivation to carry out physical exercise in this population group. The aim of this study was to carry out a systematic review of the last ten years of CE programs carried out in people with ID. The criteria established in the PRISMA statement were followed in the literature search. The databases consulted were Scopus, Web of Science, Pubmed, PsycInfo and Elton B. Stephens Company (EBSCO). Eight exclusion criteria were established for the selection of articles. For the analysis of the selected research, three quality criteria for interventions were established. Subsequently, a summary table with the characteristics of each study was made. In conclusion, it can be stated that CE programs in people with ID report benefits at both physical and psychosocial levels. It is necessary to extend this approach for the promotion of healthy physical activity that advocates social inclusion.
Food Sovereignty of the Indigenous Peoples in the Arctic Zone of Western Siberia: Response to COVID-19 Pandemic
Authors: Bogdanova Elena , Andronov Sergei , Asztalos Morell Ildiko , Hossain Kamrul , Raheem Dele , Filant Praskovia , Lobanov Andrey
Published: October 2020

This article presents the challenges facing reindeer herding as being both a profitable business and part of the traditional culture of the nomadic Indigenous peoples in the Arctic zone of Western Siberia which addresses substantial needs of the local population. Reindeer herding products are used as traditional nutrition, and as effective preventive means and remedies for adapting to the cold and geomagnetic activity in the High North. Export trends of traditional reindeer products have decreased local Indigenous peoples’ access to venison and had a negative impact on their health. Due to the COVID-19 pandemic, it is especially urgent for the Indigenous peoples to have sufficient access to traditional food and be involved in policy decision-making to maintain this traditional business. We aim to analyze the dependencies of Indigenous peoples on the reindeer produce–exporting “food value chain” and explore how (1) the independence of reindeer herders could be increased in these export chains and (2) how provision of their products to local communities could be secured. The study takes a multidisciplinary approach based on policy and socioeconomic analyses with input from medical research. Primary sources include data collected from interviews and surveys of Indigenous peoples during expeditions to the Nyda settlement, the Nydinskaya tundra, the Tazovsky settlement, the Tazovskaya tundra, the Nakhodka tundra, the Gyda and Gydansky settlements, the Yavai-Salinskaya tundra, the Seyakha settlement, the Seyakhinskaya and Tambeyskaya tundras located along the southern coast of the Ob Bay, the northeast coast of the Yamal Peninsula, the Tazovsky and Gydansky Peninsulas, and the Shuryshkarsky district. Data were collected during the summers and winters of 2014–2020.
The Analysis of Risk Factors in the Conversion from Laparoscopic to Open Cholecystectomy
Authors: Warchałowski Łukasz , Łuszczki Edyta , Bartosiewicz Anna , Dereń Katarzyna , Warchałowska Marta , Oleksy Łukasz , Stolarczyk Artur , Podlasek Robert
Published: October 2020

Laparoscopic cholecystectomy is a standard treatment for cholelithiasis. In situations where laparoscopic cholecystectomy is dangerous, a surgeon may be forced to change from laparoscopy to an open procedure. Data from the literature shows that 2 to 15% of laparoscopic cholecystectomies are converted to open surgery during surgery for various reasons. The aim of this study was to identify the risk factors for the conversion of laparoscopic cholecystectomy to open surgery. A retrospective analysis of medical records and operation protocols was performed. The study group consisted of 263 patients who were converted into open surgery during laparoscopic surgery, and 264 randomly selected patients in the control group. Conversion risk factors were assessed using logistic regression analysis that modeled the probability of a certain event as a function of independent factors. Statistically significant factors in the regression model with all explanatory variables were age, emergency treatment, acute cholecystitis, peritoneal adhesions, chronic cholecystitis, and inflammatory infiltration. The use of predictive risk assessments or nomograms can be the most helpful tool for risk stratification in a clinical scenario. With such predictive tools, clinicians can optimize care based on the known risk factors for the conversion, and patients can be better informed about the risks of their surgery.
Recruitment and Baseline Characteristics of Participants in the “Sanadak” Trial: A Self-Help App for Syrian Refugees with Post-traumatic Stress
Authors: Röhr Susanne , Jung Franziska U. , Renner Anna , Plexnies Anna , Hoffmann Rahel , Dams Judith , Grochtdreis Thomas , König Hans-Helmut , Kersting Anette , Riedel-Heller Steffi G.
Published: October 2020

Many Syrian refugees residing in Germany have been exposed to traumatizing events, while treatment options are scarce. Therefore, the self-help app “Sanadak” was developed to target post-traumatic stress in Syrian refugees. We aimed to inspect the recruitment and baseline characteristics of the participants in the trial, which is conducted to evaluate the app. Analyses were based on the recruitment sample (n = 170) and the trial sample (n = 133). Data were collected during structured face-to-face interviews in the Arabic language. Targeted outcomes included post-traumatic stress (primary; Post-traumatic Diagnostic Scale for DSM-5/PDS-5) and depressive symptoms, anxiety, resilience, among others (secondary). Recruited individuals were M = 32.8 (SD = 11.2, range = 18–65) years old; 38.8% were women. The average PDS-5 score was 23.6 (SD = 13.2) regarding trauma exposure, which was most frequently related to experiencing military- or combat-related events (32.9%). Moreover, 46.5% had major depression and 51.8% showed low resilience. Anxiety was present in 40.6% of the trial participants. Psychological distress was high in Syrian refugees residing in Germany, enrolled in a trial targeting post-traumatic stress. This underlines the need for intervention. Our results provide important figures on the mental health of a not well-studied population group in Germany.
Clinical Behavior of Ceramic, Hybrid and Composite Onlays. A Systematic Review and Meta-Analysis
Authors: Bustamante-Hernández Naia , Montiel-Company Jose María , Bellot-Arcís Carlos , Mañes-Ferrer José Félix , Solá-Ruíz María Fernanda , Agustín-Panadero Rubén , Fernández-Estevan Lucía
Published: October 2020

A systematic review and meta-analysis was performed to analyze the survival of onlay restorations in the posterior region, their clinical behavior according to the material used (ceramic reinforced with lithium disilicate, conventional feldspathic ceramic or reinforced with leucite; hybrid materials and composite), possible complications, and the factors influencing restoration success. The systematic review was based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement, without publication date or language restrictions. An electronic search was made in the PubMed, Scopus, Embase, and Cochrane databases. After discarding duplicate publications and studies that failed to meet the inclusion criteria, the articles were selected based on the population, intervention, comparison, outcome (PICO) question. The following variables were considered in the qualitative and quantitative analyses: restoration survival rate (determined by several clinical parameters), the influence of the material used upon the clinical behavior of the restorations, and the complications recorded over follow-up. A total of 29 articles were selected for the qualitative analysis and 27 for the quantitative analysis. The estimated restoration survival rate was 94.2%. The predictors of survival were the duration of follow-up (beta = −0.001; p = 0.001) and the onlay material used (beta = −0.064; p = 0.028). Composite onlays were associated with a lower survival rate over time. Onlays are a good, conservative, and predictable option for restoring dental defects in the posterior region, with a survival rate of over 90%. The survival rate decreases over time and with the use of composite as onlay material.
Spatial Patterns of Anthrax Outbreaks and Cases among Livestock in Lesotho, 2005–2016
Authors: Lepheana Relebohile Juliet , Oguttu James Wabwire , Qekwana Daniel Nenene
Published: October 2020

Background: Although anthrax occurs globally, the burden of the disease remains particularly high in Africa. Furthermore, the disease anthrax has significant public health and economic implications. However, sufficient attention has not been given to the geographic distribution of anthrax outbreaks and cases in Lesotho. Therefore, this study investigates the spatial patterns of anthrax outbreaks and cases among livestock in Lesotho from 2005 to 2016. Methods: A cross-sectional study design was adopted to realise the objectives of this study using retrospective data of anthrax outbreaks and cases recorded by the Department of Livestock Services (DLS) between 2005 and 2016. Anthrax outbreaks were geo-coded at village level and aggregated at district level. Proportions and 95% CI of anthrax outbreaks and cases by village and district were calculated. Cartographic maps displaying the distribution of anthrax outbreaks and cases at village and district level were constructed. Results: A total of 38 outbreaks were reported over the study period, and they were clustered in the Lowlands districts of Lesotho. Most outbreaks (52.6%, 20/38) in livestock were reported in the Maseru district. The Leribe district reported the lowest proportions of outbreaks (5.3%, 2/38) and cases (0.6%, 3/526). At the village level, 18% (7/38) of outbreaks were in Maseru Urban, followed by Ratau (16%, 6/38) and Mofoka (13%, 5/38). The Maseru district reported the highest (1.3%, 369/29,070) proportion of cases followed by Mafeteng (0.9%, 73/8530). The village with the most cases was Kolo (10.5%, 21/200), followed by Thaba-Chitja (7.7%, 33/430). Conclusion: Anthrax outbreaks and cases exclusively occur in the Lowlands districts of Lesotho, with villages such as Mahobong, Pitseng, Kolo, and Thaba-Chitja having a higher risk of anthrax disease. Findings of the present study have serious public health implications in light of the fact that between 2003 and 2008 Lesotho’s main abattoir was closed; hence, most of the meat in Lesotho was imported and/or sourced from the informal slaughter facilities. Much larger studies are needed to further investigate factors contributing to spatial disparities in anthrax outbreaks and cases observed in this study. Findings of the present study can be used to guide the formulation of a policy on prevention and control of anthrax in Lesotho.
Is It Helpful to Believe That Efforts Will Lead to Positive Outcomes? Two Cross-Lagged Panel Investigations among Adolescents and Young Adults
Authors: Ng Jacky C. K. , Cheung Vince W. T. , Wong Helen S. M. , Leung Sherry M. Y. , Lau Victor C. Y.
Published: October 2020

Over the past few decades, the role of self-views in life satisfaction has been extensively investigated. Recently, growing attention has been directed to the question of whether an optimistic worldview, termed “reward for application”, helps boost life satisfaction. Conceptually, the association between reward for application and life satisfaction can be paradoxical. Due to various methodological and theoretical shortfalls, previous investigations were unable to draw a robust conclusion on this association. To address these shortfalls, two cross-lagged panel studies were conducted with different time lags. Over and above the potential confounds of self-views (namely, self-esteem and self-rated personality traits), reward for application had a positive effect on lagged life satisfaction among both adolescents and young adults, while the reverse effect was not found. Moreover, we found support for the multiplicative effect between worldviews and self-views, in which the positive effect of reward for application on life satisfaction was attenuated by high self-esteem.
Magnitude and Clinical Predictors of Blood Pressure Changes in Patients Undergoing Hyperbaric Oxygen Therapy: A Retrospective Study
Authors: Schiavo Simone , Djaiani Carine , DeBacker Julian , Albertini Lisa , Santa Mina Daniel , Buryk-Iggers Stephanie , De Moraes Marcus Vinicius , Kanj Mohammad , Katznelson Rita
Published: October 2020

Hyperbaric oxygen therapy (HBOT) is widely used to treat several pathologies. The hemodynamic changes during HBOT, particularly the magnitude of arterial blood pressure (ABP) increase, are not completely understood. No clinical predictors for HBOT-induced ABP increase have been described. The purpose of this study was to quantify ABP changes in patients undergoing HBOT and to examine their predictors. This retrospective longitudinal cohort study examined 3291 elective HBOT sessions. Non-invasive ABP was recorded before and after each session. The primary outcome was to quantify the HBOT-induced ABP rise. The secondary outcome was to determine the ABP-rise predictors among demographic and clinical variables. Overall, ABP increased significantly after HBOT; this finding was more evident in the hypertensive subgroup compared to the normotensive one (+6 vs. +16.2 mmHg). Clinical predictors of significant post-HBOT ABP change were history of hypertension and pre-session baseline ABP classification. This study demonstrates an absolute HBOT-induced ABP rise. This change is clinically relevant in patients with history of hypertension. A higher baseline ABP seems a risk factor for clinically relevant ABP change. Pre-session ABP should be used clinically as an indicator for strict ABP monitoring during HBOT; future studies are recommended to explore the ABP optimization before starting an HBO treatment.
Understanding Human–Nature Connections Through Landscape Socialization
Authors: Peng Li-Pei
Published: October 2020

Understanding the landscape socialization underpinning the human–nature relationship is essential because it can contribute to assisting us to reconnect with nature. Reconnecting to nature is increasingly recognized as positively contributing to health and well-being. This study aimed to understand people’s connections with nature through landscape socialization under different land use policies. The study assumed that social values, as perceived by residents, facilitates their landscape socialization. Using a questionnaire measuring sense of community and the Social Values for Ecosystem Services application as analytical tools, the study assessed how residents with varying educational attainment, sense of community, and grounded occupation differ in identifying with conservation- and recreation-oriented policy interventions. The results demonstrated the role of landscape socialization in how people connect with nature, and the landscape socialization as a result of long-term policy interventions may exert substantial effects on residents’ social values across various spatial scales. The results deepen the general understanding of system leverage points for creating inner connections to nature which can aid sustainability transformation.
Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach: Lessons Learnt from Six Projects Conducted in the UK and The Netherlands
Authors: Devi Reena , Martin Graham , Banerjee Jay , Butler Louise , Pattison Tim , Cruickshank Lesley , Maries-Tillott Caroline , Wilson Tracie , Damery Sarah , Meyer Julienne , Poot Antonius , Chamberlain Peter , Harvey Debbie , Giebel Clarissa , Hinsliff-Smith Kathryn , Chadborn Neil , Lee Gordon Adam
Published: October 2020

The Breakthrough Series Quality Improvement Collaborative (QIC) initiative is a well-developed and widely used approach, but most of what we know about it has come from healthcare settings. In this article, those leading QICs to improve care in care homes provide detailed accounts of six QICs and share their learning of applying the QIC approach in the care home sector. Overall, five care home-specific lessons were learnt: (i) plan for the resources needed to support collaborative teams with collecting, processing, and interpreting data; (ii) create encouraging and safe working environments to help collaborative team members feel valued; (iii) recruit collaborative teams, QIC leads, and facilitators who have established relationships with care homes; (iv) regularly check project ideas are aligned with team members’ job roles, responsibilities, and priorities; and (v) work flexibly and accept that planned activities may need adapting as the project progresses. These insights are targeted at teams delivering QICs in care homes. These insights demonstrate the need to consider the care home context when applying improvement tools and techniques in this setting.
The Factorial Validity of the Norwegian Version of the Multicomponent Training Distress Scale (MTDS-N)
Authors: Hagum Cathrine Nyhus , Shalfawi Shaher A. I.
Published: October 2020

Background: Athlete self-report measures (ASRM) are methods of athlete monitoring, which have gained considerable popularity in recent years. The Multicomponent Training Distress Scale (MTDS), consisting of 22 items, is a promising self-report measure to assess training distress among athletes. The present study aimed to investigate the factorial validity of the Norwegian version of MTDS (MTDS-N) among student-athletes (n = 632) attending the optional program subject “Top-Level Sports” in upper secondary schools in Norway. Methods: A confirmatory factor analysis (CFA) was conducted to assess the six-factor model proposed by Main and Grove (2009). McDonald’s omega (ω) along with confidence intervals (CIs) were used to estimate scale reliability. After examining the fit of the CFA model in the total sample, covariates were included to investigate group differences in latent variables of MTDS-N, resulting in the multiple indicators multiple causes (MIMIC) model. Further, direct paths between the covariates and the factor indicators were included in an extended MIMIC model to investigate whether responses to items differed between groups, resulting in differential item functioning (DIF). Results: When modification indices (MIs) were taken into consideration, the alternative CFA model revealed that MTDS-N is an acceptable psychometric tool with a good fit index. The factors in MTDS-N all constituted high scale reliability with McDonald’s ω ranging from 0.725–0.862. The results indicated statistically significant group differences in factor scores for gender, type of sport, hours of training per week, school program, and school level. Further, results showed that DIF occurred in 13 of the MTDS-N items. However, after assessing the MIMIC model and the extended MIMIC model, the factor structure remained unchanged, and the model fit remained within acceptable values. The student-athletes’ reports of training distress were moderate. Conclusion: The MTDS-N was found to be suitable for use in a Norwegian population to assess student-athletes’ training distress in a reliable manner. The indications of group effects suggest that caution should be used if one is interested in making group comparisons when the MTDS-N is used among student-athletes in Norway until further research is conducted.
The Influence of Work Resources, Demands, and Organizational Culture on Job Satisfaction, Organizational Commitment, and Citizenship Behaviors of Spanish Police Officers
Authors: Marcos Alexandra , García-Ael Cristina , Topa Gabriela
Published: October 2020

The present study aims to analyze the influence of work demands and resources (support and control) on the attitudes and behaviors (satisfaction, organizational commitment, and organizational citizenship behaviors toward the organization, OCBO) of Spanish police officers, and to examine the potential mediating role of the flexibility-oriented organizational culture. Participants were 182 Spanish police officers. The analysis was carried out using the Smart PLS (Partial Least Squares) program. Firstly, reliability and convergent and discriminant validity were analyzed. Secondly, the structural model was evaluated. Overall, findings support the hypothesized model, except there was not a significant effect of demands and support on OCBO (Organizational Citizenship Behavior Organization-oriented). Results of the importance-performance map analysis also show that, in terms of predicted job satisfaction and organizational commitment, control and support are not so important, but both of them perform relatively well compared to the remaining constructs (demands and flexibility-oriented culture).
Tooth-Level Analysis of Dental Caries in Primary Dentition in Myanmar Children
Authors: Nomura Yoshiaki , Otsuka Ryoko , Wint Wit Yee , Okada Ayako , Hasegawa Ryo , Hanada Nobuhiro
Published: October 2020

In developing countries, the prevalence of dental caries in children remains high, which means that implementing a simple and convenient classification is critical. The classification needs to be evidence-based and needs to reflect tooth-level information. In this study, the prevalence of dental caries in the primary dentition of 352 Myanmar school children at the ages of 5, 6, and 7 was analyzed at the tooth level to clarify the underlying data structure of the patterns of dental caries in the population. Ninety-three percent of subjects had caries in primary dentition and the mean number of decayed teeth in primary dentition was 7.54 ± 4.82. Based on the item response theory analysis, mixed-effect modeling, and Bayesian network analysis, we proposed the following classification: Group 1: No dental caries; Group 2: Dental caries in molar teeth or dental caries in maxillary anterior teeth; Group 3: Dental caries in both molar and maxillary anterior teeth; Group 4: Dental carries in mandibular anterior teeth. Dental caries (dmft) in the groups was different between groups. The results of characteristics of tooth-level information and classification presented in this study may be a useful instrument for the analysis of the data of dental caries prevalence in primary dentition.
Dietary Exposure to Acrylamide and Associated Health Risks for the Korean Population
Authors: Lee Sanghee , Kim Hyun Jung
Published: October 2020

The aim of the study was to estimate the dietary exposure to acrylamide (AA) from the consumption of various processed food and to assess the associated health risks in different age groups in Korea. Potato crisps and French fries presented the highest mean levels of AA (546 and 372 μg/kg, respectively) followed by coffee (353 μg/kg) and tea products (245 μg/kg). The mean AA dietary exposure values for toddlers (≤2 years), children (3–6 years), children (7–12 years), adolescents (13–19 years), adults (20–64 years), and seniors (≥65 years) were estimated to be 0.15, 0.13, 0.06, 0.06, 0.08, and 0.06 μg/kg body weight (BW)/day, respectively. Based on the benchmark dose lower confidence limit (BMDL10) of 0.18 and 0.31 mg/kg BW/day, the calculated mean and 95th percentile values for the margin of exposure were below 10,000 for the all age groups suggesting possible health concern for Koreans. Biscuits, crisps, and coffee were the primary foods contributing to dietary AA exposure among these in the Korean populations. In children, considering the health risk of AA dietary exposure, especially from biscuits and crisps, there is a need to further control and modify dietary habits to ensure lower AA exposure.
Mental Health, Quality of Life and Violence Exposure in Low-Socioeconomic Status Children and Adolescents of Guatemala
Authors: Company-Córdoba Rosalba , Gómez-Baya Diego , López-Gaviño Francisca , Ibáñez-Alfonso Joaquín A.
Published: October 2020

Growing up in vulnerable conditions has an impact on children and adolescents’ mental health and well-being outcomes. However, this evidence has rarely been obtained in middle and low-income countries like Guatemala, where food insecurity and exposure to violence frequently threaten childhood development. The aim of this study was to analyse the relations that sociodemographic and socioeconomic factors have with psychological adjustment of low-socioeconomic status (SES) Guatemalan children and adolescents, and how these relations were mediated by food insecurity and exposure to violence. A total of 185 participants (50.8% girls; aged between 6 to 17, M = 11.82, SD = 3.7) from three vulnerable schools located in rural and urban areas of Guatemala were assessed. The results indicated that exposure to violence significantly moderates the effect of sociodemographic and socioeconomic variables in measures of depression, anxiety and health-related quality of life. Adolescents more exposed to violence reported higher levels of depression and anxiety, as well as lower levels of health-related quality of life. In contrast, food insecurity did not seem to influence psychological adjustment outcomes in this low-SES sample. These findings highlight the relevance of exposure to violence for mental health and well-being, and is a factor that should be considered when designing public health policies to promote children and adolescents’ welfare.
The Protective Effects of Pre- and Post-Administration of Micronized Palmitoylethanolamide Formulation on Postoperative Pain in Rats
Authors: Siracusa Rosalba , Fusco Roberta , Cordaro Marika , Peritore Alessio F. , D’Amico Ramona , Gugliandolo Enrico , Crupi Rosalia , Genovese Tiziana , Evangelista Maurizio , Di Paola Rosanna , Cuzzocrea Salvatore , Impellizzeri Daniela
Published: October 2020

Background: Postoperative pain (PO) is a common form of acute pain. Inadequate PO treatment is an important health problem, as it leads to worse outcomes, such as chronic post-surgical pain. Therefore, it is necessary to acquire new knowledge on PO mechanisms to develop therapeutic options with greater efficacy than those available today and to lower the risk of adverse effects. For this reason, we evaluated the ability of micronized palmitoylethanolamide (PEA-m) to resolve the pain and inflammatory processes activated after incision of the hind paw in an animal model of PO. Methods: The animals were subjected to surgical paw incision and randomized into different groups. PEA-m was administered orally at 10 mg/kg at different time points before or after incision. Results: Our research demonstrated that the pre- and post-treatment with PEA-m reduced the activation of mast cells at the incision site and the expression of its algogenic mediator nerve growth factor (NGF) in the lumbar spinal cord. Furthermore, again at the spinal level, it was able to decrease the activation of phospho-extracellular signal-regulated kinases (p-ERK), ionized calcium binding adaptor molecule 1 (Iba1), glial fibrillary acidic protein (GFAP), and the expression of brain-derived neurotrophic factor (BDNF). PEA-m also reduced the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) spinal pathway, showing a protective effect in a rat model of PO. Conclusion: The results obtained reinforce the idea that PEA-m may be a potential treatment for the control of pain and inflammatory processes associated with PO. In addition, pre- and post-treatment with PEA-m is more effective than treatment alone after the surgery and this limits the time of taking the compound and the abuse of analgesics.
A Bioinformatic Pipeline Places STAT5A as a miR-650 Target in Poorly Differentiated Aggressive Breast Cancer
Authors: López-Huerta Eric , Fuentes-Pananá Ezequiel M.
Published: October 2020

Breast cancer (BRCA) is a leading cause of mortality among women. Tumors often acquire aggressive features through genomic aberrations affecting cellular programs, e.g., the epithelial to mesenchymal transition (EMT). EMT facilitates metastasis leading to poor prognosis. We previously observed a correlation between an amplification of miR-650 (Amp-650) and EMT features in BRCA samples isolated from Mexican patients. In this study, we explored the cBioportal database aiming to extend that observation and better understand the importance of Amp-650 for BRCA aggressiveness. We found that Amp-650 is more frequent in aggressive molecular subtypes of BRCA, as well as in high grade poorly differentiated tumors, which we confirmed in an external miRNA expression database. We performed differential expression analysis on samples harboring Amp-650, taking advantage of gene target prediction tools and tumor suppressor gene databases to mine several hundreds of differentially underexpressed genes. We observed STAT5A as a likely putative target gene for miR-650 in aggressive poorly differentiated BRCA. Samples with both Amp-650 and low expression of STAT5A had less overall survival than samples with either or none of the alterations. No target gene has been described for miR-650 in BRCA, thus, this bioinformatic study provides valuable information that should be corroborated experimentally.
The N-Terminal Region of Yeast Protein Phosphatase Ppz1 Is a Determinant for Its Toxicity
Authors: Calafí Carlos , López-Malo María , Albacar Marcel , Casamayor Antonio , Ariño Joaquín
Published: October 2020

The Ppz enzymes are Ser/Thr protein phosphatases present only in fungi that are characterized by a highly conserved C-terminal catalytic region, related to PP1c phosphatases, and a more divergent N-terminal extension. In Saccharomyces cerevisiae, Ppz phosphatases are encoded by two paralog genes, PPZ1 and PPZ2. Ppz1 is the most toxic protein when overexpressed in budding yeast, halting cell proliferation, and this effect requires its phosphatase activity. We show here that, in spite of their conserved catalytic domain, Ppz2 was not toxic when tested under the same conditions as Ppz1, albeit Ppz2 levels were somewhat lower. Remarkably, a hybrid protein composed of the N-terminal extension of Ppz1 and the catalytic domain of Ppz2 was as toxic as Ppz1, even if its expression level was comparable to that of Ppz2. Similar amounts of yeast PP1c (Glc7) produced an intermediate effect on growth. Mutation of the Ppz1 myristoylable Gly2 to Ala avoided the localization of the phosphatase at the cell periphery but only slightly attenuated its toxicity. Therefore, the N-terminal extension of Ppz1 plays a key role in defining Ppz1 toxicity. This region is predicted to be intrinsically disordered and contains several putative folding-upon-binding regions which are absent in Ppz2 and might be relevant for toxicity.
Design and Commissioning of a Combustor Simulator Combining Swirl and Entropy Wave Generation
Authors: Notaristefano Andrea , Gaetani Paolo
Published: October 2020

Modern aero-engine combustion chambers burn a lean and premixed mixture, generating a turbulent flame which involves large heat-release fluctuations, thus producing unsteady temperature phenomena commonly referred to as entropy waves (EWs). Furthermore, to enhance the fuel air mixing, combustion air is swirled, leading to vorticity disturbances. These instabilities represent one of the biggest challenges in gas turbine design. In this paper, the design and testing of a novel entropy wave generator (EWG) equipped with a swirler generator (SG) are described. The novel EWG will be used in future works on the high-speed test rig at Politecnico di Milano to study the combustor–turbine interaction. The paper shows the process of the EWG geometry and layout. The EWG is able to produce an engine-representative EW, the extreme condition is at the maximum frequency of 110 Hz, a peak-to-valley temperature value of 20 °C and swirling angles of ±25° are measured. By virtue of these results, the proposed system outperforms other EWG devices documented in the literature. Furthermore, the addition of a swirling generator makes this device one of a kind.
Joint Sentiment Part Topic Regression Model for Multimodal Analysis
Authors: Li Mengyao , Zhu Yonghua , Gao Wenjing , Cao Meng , Wang Shaoxiu
Published: October 2020

The development of multimodal media compensates for the lack of information expression in a single modality and thus gradually becomes the main carrier of sentiment. In this situation, automatic assessment for sentiment information in multimodal contents is of increasing importance for many applications. To achieve this, we propose a joint sentiment part topic regression model (JSP) based on latent Dirichlet allocation (LDA), with a sentiment part, which effectively utilizes the complementary information between the modalities and strengthens the relationship between the sentiment layer and multimodal content. Specifically, a linear regression module is developed to share implicit variables between image–text pairs, so that one modality can predict the other. Moreover, a sentiment label layer is added to model the relationship between sentiment distribution parameters and multimodal contents. Experimental results on several datasets verify the feasibility of our proposed approach for multimodal sentiment analysis.
The Impact of Plant Essential Oils and Fine Mesh Row Covers on Flea Beetle (Chrysomelidae) Management in Brassicaceous Greens Production
Authors: Brockman Robert , Kuesel Ryan , Archer Kendall , O'Hearn Kyla , Wilson Neil , Scott Delia , Williams Mark , Bessin Ricardo , Gonthier David
Published: October 2020

Brassicaceous leafy greens are an important crop for small growers but are difficult to produce due to damage by flea beetles. Flea beetles are problematic for growers as they chew many small holes through leaves rendering produce unmarketable. We tested the efficacy of several essential oils, the woven-mesh row cover ProtekNet, and the spunbonded row cover Agribon, compared to organic and conventional insecticides and no spray controls in the spring and fall of 2019. We found that the two row cover treatments (Agribon and ProtekNet) provided the best control of flea beetles and associated damage. Thyme oil was highly phytotoxic and killed the crop entirely and rosemary and neem essential oils caused mild phytotoxic burns. Organic insecticides rarely performed better than the no spray control. While conventional insecticides controlled most flea beetles, the crop was often still too highly damaged to sell. The results of our study suggest row covers offer producers an effective method of flea beetle control that reduces their dependence on insecticides for conventional and organic production.
Spatial Distribution and Flight Patterns of Two Grain Storage Insect Pests, Rhyzopertha dominica (Bostrichidae) and Tribolium castaneum (Tenebrionidae): Implications for Pest Management
Authors: Holloway Joanne C. , Daglish Gregory J. , Mayer David G.
Published: October 2020

The lesser grain borer, Rhyzopertha dominica, and the rust red flour beetle, Tribolium castaneum, are two major beetle pests commonly found infesting stored products worldwide. Both species can cause severe economic damage and their management is complicated by their potential to develop resistance to several of the limited chemical options available. However, pest management strategies can be improved by understanding the ecology of the pest insect. To determine the spatiotemporal activity of R. dominica and T. castaneum, we conducted a trapping study over two years in a temperate region of south-eastern Australia, with traps located near grain storages and fields. We captured higher numbers of R. dominica than T. castaneum, and both species were more prevalent in traps located close to grain storages. Similar and consistent seasonal patterns were displayed by both species with activity ceasing during the winter (June–August) months. We found linear correlations between maximum daily temperatures and trap catches, and minimum threshold temperatures for flight activity were 14.5 °C and 15.6 °C for R. dominica and T. castaneum, respectively. The results are discussed in relation to the ecology of these pests along with their implications for pest management.