bluuebunny/crossref_metadata_2025 huggingface dataset:
Motivasi dan Hasil Belajar Siswa SMK Pada Mata Pelajaran Produktif, Adaptif dan Normatif
Authors: Aziz R Iklima Nur , Meilani Rini Intansari
Published: June 2022

Motivation is one of the keys to the success of student learning activities. With motivation, the learning process is believed to be easier and maximum learning outcomes can be achieved. This paper presents the results of a research aimed at determining the effect of learning motivation on learning outcomes of class X SMK students in all productive, adaptive and normative subjects. The study adopted an explanatory survey as the research method, in which a set of questionnaires consisting of 20 items of closed questions was administered as the research instrument. Respondents in this study were the students of class X semester 1 in a private vocational high school with B accreditation totaling 53 people. The results showed that there was a significant effect of learning motivation on student learning outcomes. This study supports the theory and previous research which found that the higher the level of learning motivation, the higher the level of learning outcomes achieved by students. This study emphasizes the importance of identifying student learning motivation by the teachers as a basis for formulating learning strategies and providing supporting teaching and learning facilities.ABSTRAKMotivasi merupakan salah satu kunci keberhasilan aktifitas pembelajaran siswa. Dengan adanya motivasi, proses pembelajaran diyakini menjadi lebih mudah dan hasil belajar yang maksimal dapat dicapai. Tulisan ini menyajikan hasil penelitian yang ditujukan untuk mengetahui pengaruh motivasi belajar terhadap hasil belajar siswa SMK kelas X dalam semua mata pelajaran produktif, adaptif dan normatif. Metode yang digunakan adalah eksplanatori survei dengan instrumen berupa angket yang terdiri dari 20 item pernyataan. Responden dalam penelitian ini adalah seluruh siswa kelas X semester 1 di sebuah SMK swasta dengan akreditasi B yang berjumlah 53 orang. Hasil penelitian menunjukan adanya pengaruh yang signifikan dari motivasi belajar terhadap hasil belajar siswa. Penelitian ini mendukung teori dan penelitian terdahulu yang menemukan bahwa semakin tinggi tingkat motivasi belajar maka semakin tinggi tingkat hasil belajar yang dicapai oleh siswa. Penelitian ini menekankan pentingnya identifikasi motivasi belajar siswa oleh para guru sebagai dasar dalam penyusunan strategi-strategi pembelajaran serta pengadaan fasilitas belajar mengajar yang mendukung.
Kontribusi kepemimpinan dan komunikasi interpersonal dalam meningkatkan kinerja tenaga pendidik (Kasus di SMK Muhammadiyah 1 Sumedang)
Authors: Setiawati Neng Anita , Supardi Endang
Published: June 2022

The problem of Indonesian education, especially at the SMK level, is very complex and requires serious attention. One of the highlights is the not yet optimal performance of educators in producing quality graduates. Based on the results of a study on several factors that influence the improvement of the performance of educators, it is assumed that the most dominant factors are leadership and interpersonal communication. This research uses descriptive and verification methods to answer the research hypothesis. Data were collected using a questionnaire as a data collection tool. Leadership has a contribution of  57.61% in improving the performance of educators, interpersonal communication has acontribution of 58.8% in improving the performance of educators. Meanwhile, the leadership and interpersonal communication carried out simultaneously contributed 64.5% in improving the performance of the teaching staff, with the relationship between variables being strong and high. Thus, the performance of educators can be improved by increasing the effectiveness of leadership and interpersonal communication.ABSTRAKMasalah pendidikan Indonesia terkhusus pada tingkatan SMK masih sangat kompleks dan perlu perhatian yang serius. Salah satu yang tersorot ialah belum optimalnya kinerja tenaga pendidik dalam mencetak lulusan yang berkualitas. Berdasarkan hasil kajian terhadap beberapa faktor yang menjadi pengaruh terhadap peningkatan kinerja tenaga pendidik, diduga faktor yang dominan ialah kepemimpinan dan komunikasi interpersonal. Penelitian menggunakan metode deskriptif dan verifikatif untuk menjawab hipotesis penelitian. Data diperoleh menggunakan kuesioner sebagai alat pengumpulan data. Kepemimpinan memiliki kontribusi sebesar 57,61% dalam meningkatan kinerja tenaga pendidik, komunikasi interpersonal memiliki kontribusi sebesar 58,8% dalam meningkatan kinerja tenaga pendidik. Sedangkan secara bersamaan kepemimpinan dan komunikasi interpersonal yang dijalakan memiliki kontribusi sebesar 64,5% dalam meningkatan kinerja tenaga pendidik dengan tingkat keeratan hubungan antar variabel adalah kuat dan tinggi. Dengan demikian, kinerja tenaga pendidik dapat ditingkatkan dengan cara meningkatkan efektivitas kepemimpinan dan komunikasi interpersonal.
Studi tentang pengaruh supervisi akademik pengawas sekolah dan profesionalisme guru terhadap kualitas pembelajaran di smk negeri 1 cipeundeuy
Authors: Wulandari Deri Yustin
Published: June 2022

The implementation of the school supervisor's academic supervision is an academic supervision activity carried out by the education unit supervisor towards teachers in carrying out their duties, so that they are more professional in their fields. The purpose of  this  study  was  to  clarify  the  the effect of academic supervision of school supervisors and teacher professionalism on the quality of learning. The results of the study can be concluded as follows: (1) there is a strong and significant influence of academic supervision on teacher professionalism at SMK Negeri 1 Cipeundeuy, (2) there is a moderate and significant influence of academic supervision on the quality of learning in SMK Negeri 1 Cipeundeuy, ( 3) there is a strong and significant influence of teacher professionalism on the quality of learning at SMK Negeri 1 Cipeundeuy, (4) there is a simultaneous and significant influence of academic supervision and teacher professionalism on the quality of learning at SMK Negeri 1 Cipeundeuy.
Türkçe Öğretmenlerinin Hizmet İçi Eğitim İhtiyaçları
Authors: DİLEKÇİ Atilla
Published: June 2022

Bu araştırmanın amacı, Türkçe öğretmenlerinin hizmet içi eğitim ihtiyaçlarını belirlemektir. Araştırma tarama modeline göre yürütülmüştür. 98 Türkçe öğretmenine hizmet içi eğitim ihtiyaçları anketi uygulanmıştır. Öğretmenlere uygulanan anketlerden elde edilen veriler SPSS 23.0. programıyla analiz edilmiştir. Bu veriler betimsel ve karşılaştırmalı istatistikler kullanılarak alan bilgisi, öğretmenlik meslek bilgisi ve genel kültür temalarına göre üç boyutta incelenmiştir. Araştırma sonucunda elde edilen bulgulara göre öğretmenlerin daha çok etkili iletişim ardından okuma, yazma, konuşma yöntem ve teknikleri eğitimlerine ihtiyaç duydukları belirlenmiştir. Ayrıca öğretmenlerin diksiyon ve beden dili konularında kendilerini geliştirmek istedikleri anlaşılmaktadır. COVID-19 salgınıyla birlikte eğitimde dijitalleşmenin artmasına ve eğitimde teknoloji kullanımının yaygınlaşmasına paralel olarak hem kadın hem de erkek öğretmenlerin bilgi ve iletişim teknolojileri konularında hizmet içi eğitim talepleri de artmıştır. Türkçe öğretmenlerinin hizmet içi eğitim ihtiyaçlarında cinsiyete ve hizmet yılına göre anlamlı bir fark bulunmamıştır. Genel olarak öğretmenlerin değişime açık oldukları ve bilgilerini güncellemek istedikleri söylenebilir. Araştırmada belli aralıklarla öğretmenlerin eğitim ihtiyaçlarının belirlenerek hizmet içi eğitimlerin planlanması önerilmiştir.
GENETIC AND ENVIRONMENTAL VARIABILITY, HERITABILITY AND GENETIC ADVANCE IN POD YIELD, YIELD COMPONENTS, OIL AND PROTEIN CONTENT OF PEANUT VARIETIES
Authors: KILLI Fatih , BEYCİOĞLU Tahsin
Published: June 2022

In this study, genetic and environmental variability, broad-sense heritability, genetic advance and correlation coefficients of pod yield, yield components, oil and protein content of ten registered peanut varieties were examined. Year (Y), location (L), year x location interaction (Y x L), genotype (G), genotype x year interaction (G x Y), genotype x location interaction (G x L) and genotype x year x location interaction (G x Y x L) were significant, but G x Y for shelling percentage was not significant. Genotypic and phenotypic variances were highest for pod yield followed by hundred pod weight, whereas all investigated traits of peanut varieties were significantly different. Broad sense heritability estimates ranged from moderate level to high. Heritability values were estimated to be maximum for shelling percentage (95.4%), hundred kernel weight (91.6%), hundred pod weight (88.3%), while moderate for pod number (63.8%), pod weight (60.4%), first quality pod ratio (63.3%), pod yield (63.2%), oil content (52.0%) and protein content (52.5%). High heritability for shelling percentage, hundred kernel weight and hundred pod weight indicated that these characteristics were affected less than the others by the environmental conditions. The magnitudes of genetic advance were observed to be very high (>50%) for hundred pod weight, 100 kernel weight, pod weight and pod yield; moderate (20-50%) for pod number, first quality pod ratio, shelling percentage and low (
EFFECTS OF SUPPRESSION APPLICATIONS ON SUMMER ASPHODEL (Asphodelus aestivus Brot.) DENSITY, BOTANICAL COMPOSITION, FORAGE YIELD AND QUALITY OF AEGEAN RANGELANDS
Authors: SÜRMEN Mustafa , KARA Emre
Published: June 2022

Summer asphodel (Asphodelus aestivus Brot.) has an underground storage organ that enables the plant tosurvive extreme conditions and contains alkaloids that are toxic to the livestock in rangelands. For this reason,the experiment was carried out in the rangeland of Aydin province (Turkey) in order to determine the mosteffective methods of weed management where there is an increase in the summer asphodel (Asphodelus aestivusBrot.) population. In the study, the effects of 8 different control methods (control, mowing, fertilization,paraquat, glyphosate, 2,4-D, 2,4-D + Picloram, grubbing) on yield, quality and botanical composition wereinvestigated. Result of the findings in this study shows that the grasses increased more in vegetation. The highestvalues of hay yield were observed in paraquat and fertilization applications. High values of crude protein yieldwere found in fertilization and grubbing applications. The lowest population of summer asphodel (Asphodelusaestivus Brot.) was obtained grubbing and paraquat applications. Together with these results, grubbing,fertilization, paraquat and glyphosate applications come to the fore. However, due to the high workforce, it issignificant to choose an application considering the size of the rangeland and the population of the indicatorweed species.
Interspecific variability in morphological characters of species of the genus Dasiphora in Northeast Asia
Authors:   Amur Branch of Botanical Garden-Institute FEB RAS, Andysheva Elena V.
Published: June 2022

The results of the study of the interspecific morphological variability of five species of the genus Dasiphora Raf. are presented. We found that some qualitative and quantitative characters of leaf and calyx of Dasiphora are species-specific and suitable for species identification. The level of variability of quantitative morphological parameters was estimated using the coefficient of variation. Similarities and differences between species of the genus Dasiphora established by morphological characters confirm the taxonomic diversity in this genus.
Research of stress-deformed states of eccentrally compressed elements of annular section
Authors: Mordovsky Sergey S. , Frantseva Daria O.
Published: June 2022

The results of the study of eccentrically compressed reinforced concrete elements of an annular section are compared in terms of strength characteristics. The analysis carried out basically contains the use of a non-linear deformation model, which brings the behavior of concrete closer to real experimental conditions. A comparative analysis of the results of calculating the strength of reinforced concrete elements of an annular section according to the method proposed in the current set of rules, the author's program for determining the stress-strain state of a reinforced concrete column of an annular section, implemented in the MathCad software environment, and a numerical experiment in the Lira-SAPR software package is given. Calculations and schemes are given taking into account the possibility of conducting an experimental study.
Causes of defects of the heating network
Authors: Zelentsov Danila V.
Published: June 2022

The errors that occurred during the design of a channelless heat network and led to defects in the process of functioning of the heat supply system are considered and analyzed. To determine the cause of defects, the work performed was checked for compliance with the adopted design decisions, as well as an analysis of the design decisions themselves. It was found that the cause of defects during operation are errors in the adopted design decisions.
Features of operation of ultra-small sewage water treatment plants of northern design with membrane technology
Authors: Morozov Stepan A. , Serpokrilov Nikolay S.
Published: June 2022

The conditions of operation of ultrasmall sewage treatment plants SWTP - 30 with membrane technology located at a warehouse production facility in the Arctic of Russia with coordinates 67.4973, 86.3261 are considered. The parameters of the SWTP operation are explained after the modernization to supplement the cleaning scheme with a secondary clarifier.
Technological features of the ducker device for transportation of petroleum products
Authors: Ryazanova Galina Nikolaevna , Churilina Yulia Yu.
Published: June 2022

The efficient operation of main oil pipelines - one of the most important and urgent problems of Russia. Ducker - one of the most technologically advanced stages of construction of the road trunk pipeline. It is important to make the right choice of the method for installing the pipeline, since the speed of construction, economic costs of work, the reliability of the underwater crossing section, and, as a consequence, the uninterrupted operation of the entire main oil pipeline, environmental friendliness of both the installation and further operation will depend on this. underwater passage. Thus, the purpose of this work is to perform a comparative analysis of the methods for the construction of siphons, highlighting the advantages and disadvantages of each method. The results of the work can be applied in the construction of a new route, as well as in the overhaul of underwater crossings that have worked out their time.
Space-void dichotomy in architecture
Authors: Repina Evgenia A. , Kursova Marina G.
Published: June 2022

The article raises the issues of annihilation of places without a direct function in the urban space in the context of the implementation of standards for the development of territories and the desire for their mass replication. In view of the widespread perception of urban wastelands with a negative connotation, the article explores the understanding of the category of void in architectural theory and practice on a positive basis. The differences between the attitude to space as an object in the modernist design method and void as the subject of the modern postmodernist method are described. The properties and values of void are considered in order to return subject-subject relations to void as a value, to clarify its potential for introduction into the project method as a category that has significant axiological properties in comparison with space. Rehabilitating the repressed meaning of void is seen as the key to major professional change. It is proposed to consider void as an integral part of poetic experience and as a manifesto of a new form of architecture.
IoT Security Evolution: Challenges and Countermeasures Review
Authors: Abuagoub Ali M. A.
Published: June 2022

Internet of Things (IoT) architecture, technologies, applications and security have been recently addressed by a number of researchers. Basically, IoT adds internet connectivity to a system of intelligent devices, machines, objects and/or people. Devices are allowed to automatically collect and transmit data over the Internet, which exposes them to serious attacks and threats. This paper provides an intensive review of IoT evolution with primary focusing on security issues together with the proposed countermeasures. Thus, it outlines the IoT security challenges as a future roadmap of research for new researchers in this domain.
Secure Location-Aided Routing Protocols With Wi-Fi Direct For Vehicular Ad Hoc Networks
Authors: Saleh Ma'en , Dong Liang , Aljaafreh Ahmad , Al-Oudat Naeem
Published: June 2022

Secure routing protocols are proposed for the vehicular ad hoc networks. The protocolsintegrate the security authentication process with the Location-Aided Routing (LAR) protocol to supportWi-Fi Direct communications between the vehicles. The methods are robust against various security threats.The security authentication process adopts a modified Diffie-Hellman key agreement protocol. The Diffie-Hellman protocol is used with a short authentication string (SAS)-based key agreement over Wi-Fi Directout-of-band communication channels. It protects the communication from any man-in-the-middle securitythreats. In particular, the security process is integrated into two LAR routing schemes, i.e., the request-zoneLAR scheme and the distance-based LAR scheme.We conduct extensive simulations with different networkparameters such as the vehicular node density, the number of the malicious nodes, and the speed of thenodes. Simulation results show that the proposed routing protocols provide superior performance in securedata delivery and average total packet delay. Also, the secure distance-based LAR protocol outperforms thesecure request-zone LAR protocol.
Psychological Wellbeing and Psychological Distress in the Elderly during the COVID-19 Pandemic
Authors: Herdian Herdian , Suwarti Suwarti , Estria Suci Ratna
Published: June 2022

BACKGROUND: The elderly population is deemed to be the most vulnerable to the effects of the COVID-19 pandemic. From March 2020 to April 2022, the implementation of psychological distancing is still being applied in Indonesia. In the light of the pandemic, mental health problems among the elderly require further exploration. This study examines the mental health status of the elderly during the COVID-19 pandemic in Indonesia and the factors that affect their mental health, such as loneliness and attachment to God.
METHODS: A sequential explanatory type of the mixed-method approach was adopted for the purposes of this study. In particular, the researchers first conducted a quantitative survey, analyzed its results, and then explained them in more detail using qualitative research.
RESULTS: The results show that loneliness is a predictor of mental health in the elderly, while attachment to God does not correlate with mental health. More specifically, we described that minimal activity, inability to meet children and grandchildren, and inability to recite the Quran were the main factors triggering sadness among the elderly during the COVID-19 pandemic. Furthermore, we defined that elderly people use productive and religious activities, and communication as main coping strategies.
CONCLUSION: Loneliness has been a serious problem for the elderly during the COVID-19 pandemic, impacting their mental health. The findings of this research can be used as a basis or reference for maintaining the mental health of the elderly during the pandemic.
Van Gölü’nün (Doğu Anadolu) Holosen kıyı şeridi gelişimi üzerindeki doğal ve insan kaynaklı itici güçler: Jeomorfolojik bir yaklaşım
Authors: ÜNER Serkan
Published: June 2022

Coastal areas of the lakes are quite sensitive to climatic, hydrologic, and anthropogenic changes. These areas are also an indicator that reveals the interaction between natural driving forces and anthropogenic factors. Lake Van coastal region is a dynamic area heavily affected by the natural processes and human activities. The present study focuses on coastline evolution and associated driving forces of the Lake Van. Natural driving forces influencing the changes in the coastline were determined as rock type, water-level fluctuations, wave and current action, tectonics, and fluvial-based processes. The eastern coasts of lake are identified as the most intensive region for the erosion and deposition in terms of natural factors.

Most of the residents prefer to live in the coastal areas of the Lake Van, likely large percentage of the world's population choice. Coastal settlements and their coastal protection structures such as embankments and harbours negatively affect the natural processes such as erosion, sediment transportation, and deposition. Dams and river reclamation channels in rivers indirectly affect the coastal evolution by reducing the sediment input into the lake. These anthropogenic stressors on coastal evolution completely change the natural balance. Understanding of all these environmental factors is an indicator for the existing circumstances of the Lake Van coastal area and provides wider perspective to assess of protection and management of this area.
Effects of a rehabilitation program for Parkinson’s patients on reaction and movement time: an electromyographic study
Authors: KIZIL Nurhan , ÖĞÜT Halil , OKUYUCU Esra , GÜLER Hayal , ÖZER Cahit , TURHANOĞLU Ayşe Dicle
Published: June 2022

Purpose: The aim of the study was to investigate the effects of a rehabilitation program consisting of specific exercises for Parkinson's Disease (PD) patients on reaction time (RT), movement time (MT), quality of life and disease activity.

Materials and Methods: A total of 26 idiopathic PD patients were included in the study. The exercises specific to Parkinson’s were applied to the patients for 16 weeks. The evaluation of the patients were done before and after the treatment. The disease severity was measured with Unified Parkinson’s Disease Rating Scale (UPDRS), quality of life was measured with Short Form-36 (SF-36). RT and MT measurements were done electromyographically.

Results: There was no statistically significant difference in UPDRS total and sub-section values and SF-36 quality of life evaluation before and after the exercise program. While a significant decrease was observed in the RT values of the patients after the 16 week exercise program compared to prior to the program (Deltoid RT 370.46 ± 25 to 219.58 ± 17, biceps RT 370.42 ± 27 to 216.49 ± 14 and triceps RT 445.21 ± 31 to 247.53 ± 23, respectively).

Conclusion: In PD, the rehabilitation program specific to the disease leads to a significant decrease in RT. Although the exercise has no statistically significant effect on disease activity, quality of life and MT values, it was seen that it still led to improvement.
Impact of gossypin on gene expression of HSP60 and HSP70 in different cancer cell lines
Authors: DİRİCAN Ebubekir , ÇINAR İrfan
Published: June 2022

Purpose: The aim of this study is to evaluate the impact of gossypin on the expression level of heat shock proteins (HSPs) genes in different cancer cells.

Materials and Methods: Cells were grown under standard culture conditions. Cancer cells were treated with different concentrations (5-100 µg/ml) of gossypin and cisplatin (50 µM) as positive control. Cell viability and effective dose range (5-100 µg/ml) of gossypin were determined by MTT at 24, 48 and 72 hours. After RNA isolation and cDNA synthesis, HSP60 and HSP70 gene expression levels were analyzed using RT-PCR. For gene expression analysis, the 2-∆∆ct method was used.

Results: According to the MTT results, 25-50-100 µg/ml of gossypin doses were found effective on HSP60 and HSP70 gene expression levels in the cancer cell lines. Gossypin affected with dose-dependently the expression of HSP60 and HSP70 in the three cell lines. In the three cell lines, 50 µg/ml and 100 µg/ml of gossypin doses significantly reduced the expression of HSP60 and HSP70 compared to control group.

Conclusion: Our results strongly supported the anticarcinogenic effect of gossypin at various doses in different cell lines. However, we believe that further in vivo research and human studies are needed. Our findings suggest that gossypin could be suitable candidate agent for further investigation to develop new strategies for the prevention and/or treatment of different cancer types.
Hidrojen Sülfür’ün Fizyolojik ve Patolojik Olaylara Katkısı ve Klinikte Kullanımı
Authors: GÖNBE Kübra , AYDINOĞLU Fatma , ÖĞÜLENER Nuran
Published: June 2022

Enzimatik veya non-enzimatik yollarla sentezlenen hidrojen sülfür (H2S), nitrik okside (NO) ve karbonmonoksite (CO) benzer üçüncü bir gaz nörotransmitterdir. Vücutta sentezinden sorumlu enzimler çeşitli dokularda eksprese edilmektedir. Antiinflamatuvar, antiapoptotik, nöroprotektif, gastroprotektif, antispazmotik, sitoprotektif, antioksidan, bronkodilatör, kan basıncı regülasyonu gibi birçok fizyolojik etkisi olan H2S’in, hipertansiyon, ateroskleroz, depresyon, astım, kronik obstrüktif akciğer hastalığı, ülser, erektil disfonksiyon, parkinson ve alzheimer gibi çeşitli patolojik durumlarda da rolü olduğu bilinmektedir. Fizyopatolojik durumlardaki potansiyel önemi göz önüne alınarak H2S salıveren aspirin ve naproksenle kombine çeşitli preperatlar geliştirilmiştir. Bu kapsamda antiinflamatuvar, analjezik, antioksidan, sitoprotektif ve kardiyoprotektif etkiler gösteren bazı aday ilaçlar geliştirilmiştir. ATB-346, GIC-1001, NBS-1120, SG-1002, AP-39 ve MZe76 aday ilaçlar arasında yer almaktadır. S-zofenoprilin isimli ilacın ise faz çalışmaları tamamlanmıştır. L-sistein/H2S yolağıyla ilgili preklinik ve klinik araştırmaların gerçekleştirilmesi fizyolojik, patolojik ve terapötik açıdan önem taşımakta ve bu doğrultuda yeni preperatların geliştirilmesinin tedavi yaklaşımları için umut verici olduğu düşünülmektedir.
Neonatal Polisitemi ve Hiperviskozite Sendromu
Authors: ELBAYİYEV Sarkhan , ÇAKIR Ufuk
Published: June 2022

Neonatal polisitemi yenidoğan bebeklerde sıklıkla karşılaşılan klinik bir tablodur. Erişkin hematokrit değerinden fizyolojik olarak daha yüksek değerlerde doğan yenidoğan bebeklerin polisitemi tanımı iyi bilinmesine rağmen hangi hematokrit değerinde nasıl tedavi edileceği konusu belirsizliğini korumaktadır. Polisiteminin hafif klinik semptomlarına ek olarak santral sinir sisteminde infarkta kadar ağır komplikasyonlara neden olduğu düşünüldüğünde bu konuda hazırlanmış güncel yaklaşım kılavuzlarına ihtiyaç vardır. Bu derlemede neonatal polisitemiye yaklaşım güncel verilere dayanarak hazırlanmıştır.
Kanserde Hedefe Yönelik Tedavi: Tirozin Kinaz İnhibitörleri
Authors: KÜPELİ Serhan
Published: June 2022

Kanserler genel olarak çoklu genetik ve epigenetik anormallikler içermekte fakat birkaç anahtar gen sayesinde malign fenotip ve hücresel sağkalımın devamlılığı sağlanmaktadır. Tirozin kinazlar sıklıkla büyüme faktörleri, sitokinler ve hormonlar ile hücresel cevapta rol oynarlar. Bu moleküller tümör büyümesinden çeşitli mekanizmalarla sorumludurlar. Tirozin kinaz inhibitörlerin geniş bir terapötik etkinliğinin olabileceği düşünülmektedir. Tek ilaçla yapılan tedavide bu inhibitörlerin hiçbiri ile faz 1 çalışmalarda önemli cevap oranları elde edilememiş olup yüksek dozların kısa sürelerde verilmesi ve değişik yolaklara etkili olabilecek ilaçların kombine edilmesi gibi diğer seçenekler araştırılmaktadır.
Ashâbü'l-Uhdûd Kıssasının Tahlili
Authors: YAZICI Elif
Published: June 2022

Bu araştırma, el-Burûc 85/4-10. ayetlerde zikredilen Ashâbü’l-Uhdûd kıssasının tarihî ve kültürel tahlilini içermektedir. Amacı, Ashâbü’l-Uhdûd’un kimliklerini tespit etmek, bu kıssanın tarihî gerçekliğini değerlendirmek ve kıssadaki müphemlikleri açıklığa kavuşturmaktır. Ashâbü’l-Uhdûd kıssasına dair üç rivayet öne çıkmaktadır. Bunlara göre çukurlar, İran hükümdarı, Buhtunnasr veya Zûnüvâs dönemlerinde kazılmıştır. Rivayetler tarih-vâkıa uyumu yöntemiyle değerlendirilmiştir. Girişte araştırmanın konusu, kapsamı, amacı, önemi, metodu ve kaynakları hakkında bilgiler sunulmuştur. İlk olarak Ashâbü’l-Uhdûd’un kimliğine ve hâdisenin tarihine değinilmiş, daha sonra her bir rivayet ayrı başlıkta değerlendirilmiştir.
Relationships between leaf water potential and soil water potential in grasses subjected to water stress
Authors: André Tapparo Sergio , Duarte Coelho Rubens , Costa Jéfferson , Weine Paulino Chaves Sérgio , Alberto Quiloango-Chimarro Carlos , Dos Santos de Oliveira Everton
Published: June 2022

For grasses and other crops in general, soil water potential has been widely studied to determine if there is a deficit or excess of water content in the soil. However, the plant water absorption process is not only modulated by soil water potential but also by the combination of meteorological, soil depth, and crop canopy factors, which could be elucidated through water relations responses. The objective of this work was to compare the water relations of grass species established in different soil depths and subjected to water stress. Santo Agostinho (Stenotaphrum secundatum), Esmeralda (Zoysia japonica), Tanzania (Panicum maximum) and Tifton 85 (Cynodon spp.) were used in this trial. The four species of grasses were tested in four different soil rooting depths: 10, 20, 30 and 40 cm. The grasses were irrigated at soil moisture field capacity level, until the time of imposing the water stress period. Soil depth had a direct influence on leaf water potential and soil water potential. Moreover, correlation coefficients are higher in deeper soil profiles. The strongest correlations between leaf water potential and soil water potential were found in the deeper soil depth treatments. Therefore, for the soil depth treatment of 40 cm, the average R² for the four species was 0.55, the highest being 0.70 in Tanzania grass. It is possible to relate leaf water potential and soil water potential independently of the grass species used or the depth of soil available to the roots, which would allow the creation of new irrigation management strategies.
Distal humerus fractures: closed reduction and percutaneous pinning versus open reduction and internal fixation
Authors:   Guru Gobind Singh Medical College, Faridkot, India, Gupta Pranav , Garg Shipra ,   Guru Gobind Singh Medical College, Faridkot, India, Garg Keerty ,   Kalpana Chawala Government Medical College, Karnal, India, Jindal Mohit ,   Kalpana Chawala Government Medical College, Karnal, India
Published: June 2022

Introduction Distal humerus fractures are relatively rare and being intra-articular are difficult to manage. As the number of elderly people grows steadily and also with increasing use of motor vehicles in the developing countries, it can be said that the frequency of intraarticular fractures of the distal humerus will increase similar to the fractures of the distal end of the radius, hip, and spine. There are several treatment plans for managing intraarticular fractures of the distal humerus depending on fracture anatomy. We conducted this study to assess which approach is superior, closed percutaneous reduction with K-wires or ORIF. Methods A total of 30 patients who satisfied the inclusion criteria were included, out of which 16 patients underwent ORIF and 14 patients underwent closed reduction and percutaneous pinning (СRPP). Patients included were between 21–50 years of age with intraarticular nonpathological closed distal humerus fractures without preoperative neurovascular deficit and presented less than 10 days between the fracture event and treatment. Results In our study, mean age of patients undergoing CRPP was 28.1 years while the mean age of patients undergoing ORIF was 30.1 years. This study showed that distal humerus fractures are more common in younger age groups. In our study, mean arc of motion at 6 months postoperatively in patients which underwent CRPP was 106.07 degrees while the mean arc of motion in patients which underwent ORIF was 80.94 degrees. In patients who underwent ORIF, only 6.2 % (1/16) had excellent outcome, 56.3 % (9/16) patients had good outcomes, 31.3 % (5/16) patients had fair outcomes, and 6.2 % (1/16) had poor outcome. It was found that out of a total of 14 patients which underwent CRPP, only 7.1 % (1/14) had cutaneous impingement. Fracture union occurred in 100 % of patients except 3 patients in ORIF group; however, they had partial union up till 6 months of follow-up. Conclusion Our study concludes that even displaced intra-articular fractures of the distal humerus can be satisfactorily treated with closed reductions and percutaneous pinning.
Femoral neck nonunion: new classification used in total hip arthroplasty in elderly patients
Authors:   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Tsed A.N. , Mushtin N.E. ,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Shmelev A.V. ,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Dulaev A.K. ,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
Published: June 2022

Introduction The risk of the femoral neck fracture nonunion is 48 % with avascular necrosis of the femoral head being reported in 42 % of cases. There are many classifications of acute intra-articular fractures of the proximal femur and there are no grading systems for femoral neck nonunions that would allow prediction of outcomes of total hip arthroplasty (THA). The objective was to evaluate mid-term results of THA in patients with femoral neck nonunion and develop a new classification of nonunions. Material and methods A prospective cohort single-center comparative study included 78 elderly patients with atrophic femoral neck nonunions treated with primary THA. The mean follow-up period was 24.2 months. Three prospective groups were identified. Separation criteria included shortening of the lower limb and femoral offset, changes in the Barnett-Nordin index, the Hounsfield bone density index, the presence of metal constructs and bone defects. Groups A and B were divided into 2 subgroups depending on the presence/absence of fixation metal constructs for a femoral neck fracture. Group C was divided into 2 subgroups: type C1, acetabular defect and type C2, proximal femur defect. Results Mean operating time was 81.1 minutes in group A, 102.9 minutes in group B and 145.2 minutes in group C. The minimum blood loss was recorded in group A measuring on average 429.25 mL in both subgroups. The maximum blood loss was seen in patients of groups B and C measuring 606.62 mL and 631.5 mL. Overall revision rate was 7.7 %. Conclusion A classification for femoral neck nonunions was developed suggesting grading patients into 3 types: type A, type B and type C which were further divided into 2 subtypes. The grading system was based on lower limb shortening and femoral offset, severity of osteoporosis, presence of metal constructs and acetabulum or proximal femur bone defect which prognostically affected the outcome of THA.
Surgical treatment of Hallux extensus
Authors:   Federal Research and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Moscow, Russian Federation, Yakushev D.S. , Protsko V.G. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation,   City Clinical Hospital named after S.S. Yudin, Moscow, Russian Federation, Zagorodny N.V. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation, Shultz O.A. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation, Makinyan L.G. ,   Peoples’ Friendship University of Russia, Moscow, Russian Federation,   City Clinical Hospital named after S.S. Yudin, Moscow, Russian Federation
Published: June 2022

Introduction This study is a comparative assessment of early and long-term results of two different methods of surgical treatment of hallux extensus. Materials and methods The results of surgical treatment of 22 patients with Hallux extensus at the orthopedic department of the Moscow Yudin City Hospital from 2017 to 2019 were studied. The patients were divided into 2 groups depending on the tactics of surgical treatment. The main goal of this study is a comparative assessment of the functional results of two surgical techniques. The first group of patients, which included 11 subjects, underwent needle percutaneous tenotomy of the extensor tendon of the big toe, the second group, which also consisted of 11 people, underwent tenodesis of the tendon-muscular part of the short flexor of the big toe according to the proposed by us technique. Results The study results are based on the assessment of subjective patient satisfaction and radiography images, as well as on the ACFAS score. In the group of patients who underwent percutaneous tenotomy of the extensor tendon of the big toe, there was a recurrence of deformity in 4 patients (36 %) and insufficient correction of the deformity in 2 patients (18 %). In the group of patients who underwent tenodesis of the tendon-muscle part of the short flexor of the big toe, 100 % showed good functional results, pain relief and esthetic effect. Good treatment results were observed in 73.3 % of the patients. Conclusions Analysis of the clinical results of surgical treatment showed a high efficacy of tenodesis of the tendon-muscle part of the short flexor of the big toe in comparison with percutaneous tenotomy of the extensor tendon of the big toe. Positive results were achieved in 100 % of cases. No recurrence of deformity was observed. The patients did not complain of pain, and there were no problems with footwear in the postoperative period.
Freiberg-Köhler disease: clinical manifestations, diagnostics, and treatment (literature review)
Authors:   Novosibirsk Y.L. Tsivian Research Institute of Traumatology and Orthopaedics, Novosibirsk, Russian Federation, Gudi S.M. , Luchshev M.D. ,   Novosibirsk Y.L. Tsivian Research Institute of Traumatology and Orthopaedics, Novosibirsk, Russian Federation, Kuznetsov V.V. ,   Novosibirsk Y.L. Tsivian Research Institute of Traumatology and Orthopaedics, Novosibirsk, Russian Federation, Skuratova L.K. ,   Novosibirsk Y.L. Tsivian Research Institute of Traumatology and Orthopaedics, Novosibirsk, Russian Federation, Prokaev F.V. ,   Novosibirsk Y.L. Tsivian Research Institute of Traumatology and Orthopaedics, Novosibirsk, Russian Federation, Pakhomov I.A. ,   Novosibirsk Y.L. Tsivian Research Institute of Traumatology and Orthopaedics, Novosibirsk, Russian Federation
Published: June 2022

Introduction The paper deals with the main aspects of osteochondropathy of the heads of the II–V (small) metatarsal bones. The relevance of the problem of treating patients with Freiberg-Kohler disease can be explained by high incidence and poor results of traditional methods of its management. Objective The aim of this work was an attempt to generalize the available data and improve the understanding of approaches to the treatment of osteochondropathy of the heads of the II–V metatarsals. Materials and methods The publications obtained in various information systems (PubMed, eLibrary.ru, Google Scholar) were reviewed. Results Issues of history, etiology, pathogenesis, systematization and diagnosis of this disease were highlighted. The analysis of existing methods of treatment was carried out. Their advantages and disadvantages were assessed. Conclusion Despite more than a century of studies on Freiberg-Kohler disease, the available literature is scarce. Most works are case reports or series of cases describing small samples. This fact significantly reduces the scientific value. Thus, improving the methods of diagnosis and treatment of patients with this disease based on the foundations of evidence-based medicine is a task of current traumatology and orthopedics.
Foot deformities in patients with diabetic foot disease (literature review)
Authors:   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Bardyugov P. S. ,   Endocrinology Research Centre, Moscow, Russia, Parshikov M.V. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
Published: June 2022

The objective was to review the orthopaedic literature on treatments of diabetic foot disease. Material and methods PubMed, CyberLeninka, Google Scholar, Scopus, Medline, eLIBRARY were searched. Studies in English and in Russian that reported foot deformities in the pathogenesis of diabetic foot disease and orthopaedic correction methods in the complex treatment of this late complication of diabetes mellitus were included for review. All study designs were considered. The search was produced using the following terms: diabetes mellitus, foot deformities, diabetic foot syndrome, orthopaedic treatment, osteotomy, metatarsophalangeal arthroplasty, achilles tendon lengthening. Literature sources reporting methods of orthopaedic correction of foot deformities in isolation from the diabetic foot syndrome and literary sources reporting manifestations of the diabetic foot syndrome without description orthopedic methods of treatment (surgery for purulent complications, vascular surgery, hypoglycemic therapy) were excluded from the study. Results The literature review allowed us to evaluate the role of orthopaedic treatment of foot deformities in patients with diabetic foot syndrome to be addressed either conservatively or surgically. The effectiveness of conservative methods has long been reported in studies with higher degree of evidence. Surgical correction of DFS through orthopaedic interventions has not been covered in such detail. Conclusion The literature review focused on the topical issue at the junction of various medical specialties. The results of treatment reported by Russian and foreign authors were analyzed. "Blind spots" in the literature were explored, goals for subsequent research delineated.
Role of oral physician in private dental setting
Authors: Afaque Sarah , Misra Neeta , Umapathy Deepak , Srivastava Saurabh
Published: June 2022

The Oral Medicine and Radiology branch is an essential bridge between Dentistry and Medicine. Oral physicians are often sought to manage the oral symptoms or know if the oral disease poses a risk of oral cancer or cross-infection in the clinics. Recent studies indicate an increased prevalence of oral habits-related lesions in India. Hence, proper support of OMR specialists along with a global strategy to promote the clinical practice of Oral Medicine among patients and all other healthcare professionals is inevitable to increase awareness of the specialty, thus encouraging the budding OMR specialist to establish themselves independently in private practice.
Współczesne ujęcia empirycznego charakteru teologii duchowości
Authors: Miczyński Jan
Published: June 2022

Artykuł przedstawia współczesną refleksję nad wyodrębnioną z nauk teologicznych w XX wieku – teologią duchowości. Wyjaśnia jej empiryczny charakter, który polega na badaniu doświadczenia duchowego konkretnych ludzi – czy to bezpośrednio (przez obserwację), czy też pośrednio (poprzez teksty). Analizując wybraną współczesną literaturę, artykuł ukazuje różne koncepcje możliwości teologicznego poznania doświadczenia. Przybliża metody badawcze stosowane aktualnie przez teologów duchowości (obok metod tradycyjnych: dedukcyjnej, opisowej, fenomenologicznej).

Artykuł ukazuje proponowane nowe metody, ocenia je i grupuje w sposób następujący: a) metody poznawania poprzez osobiste doświadczenie; b) metody obserwacji; c) metody interpretacji tekstów – hermeneutyczne; d) metody stanowiące zasadę scalającą. Poprowadzona w ten sposób analiza współczesnej refleksji dotyczącej empirycznego charakteru duchowości, prowadzi no następujących wniosków: a) dostrzega się wiele prób poszukiwana nowych, bardziej szczegółowych metod poznawania doświadczenia duchowego ludzi; b) teologia duchowości inspiruje się w tym wieloma naukami humanistycznymi; c) wielość metod podkreśla wielowymiarowość ludzkiego doświadczenia, misterium ludzkiej osoby; d) przy skupieniu się tylko na jednej metodzie szczegółowej, istnieje niebezpieczeństwo redukcjonizmu; e) potrzebna jest jakaś metoda scalająca wszystkie inne metody – wydaje się, że może być nią metoda personalistyczna.

System personalistyczny przyjmuje, że kluczem hermeneutycznym do rozumienia wszelkiego doświadczenia jest misterium osoby.
On the Development of the Mariological Thought and Marian Devotion of Pope Saint John Paul II. Marian Doctor of the Church?
Authors: Thomas William A.
Published: June 2022

The complexity of Mariology is such that it can only be described by typology or by relationships. Pope Saint John Paul II develops both of these methodologies in dealing with the role of the Virgin Mary as Mother of the Church, a personal Mother to each human being and Mother of the Word Incarnate. This short paper looks at some of the writings and footnotes which are contained therein which show his love of certain Fathers of the Church such as Saint Bernard of Clairvaux and Saint Louis Marie Grignion de Montfort. In addition to the documents of the Second Vatican Council the Holy Father draws on these two great Saints and devotees of the Blessed Virgin in order to develop a Mariology and devotion suitable for the modern world. Francisco Suarez S.J who developed the systematic approach to Mariology is sidelined by Pope John Paul II in favour of Saint Louis de Montfort and with this approach he is able to bring the study of Mary to a new level where She will be known and loved.
Mariologia i pobożność maryjna św. Piotra Damianiego (1007–1072)
Authors: Królikowski Janusz
Published: June 2022

Piotr Damiani należy do wyjątkowo ważnych postaci w Kościele XI wieku, ponieważ przyczynił się do jego odnowy. Jednym z zasadniczych czynników tej odnowy uczynił teologię, mocno zakorzenioną w Tradycji, ale równocześnie otwartą na nowe wyzwania. Można w tej teologii wskazać także wiele tematów, które dotyczą osoby i misji Maryi, Matki Bożej, a także pobożności maryjnej. Zwłaszcza ta pobożność okazała się bardzo wpływowa w dziedzinie odnowy duchowej, a tym samym stało się faktem, że uwzględnianie mariologii i pobożności maryjnej powinno zawsze stanowić konieczny element działań na rzecz odnowy Kościoła w każdej epoce. Artykuł stanowi zatem próbę ukazania mariologii i pobożności maryjnej w pismach św. Piotra Damianiego.
Pokój i harmonia w Traktacie o pokoju Gilberta z Tournai (1200–1284)
Authors: Block Wiesław
Published: June 2022

Gilbert z Tournai, brat mniejszy, żyjący w XIII wieku, w swoim dziele Traktat o pokoju (Tractatus de pace et tranquillitate animi) podejmuje temat harmonii i pokoju, analizując tę rzeczywistość z wielu perspektyw. Jego praca, pod względem metodologii jak i treści, w pełni odzwierciedla średniowieczne podejście do problemu, jednocześnie jednak wprowadza nowe perspektywy i poszerza horyzonty myślowe, bazując na długoletnim doświadczeniu akademickim jej autora. Odtworzenie najważniejszych idei tego dzieła i refleksja nad nimi są głównym przedmiotem niniejszego studium.
Disaster Risk Reduction Lessons from February 7, 2021 Flash Flood in Uttarakhand Province of India
Authors: Rautela Piyoosh , Jugran Rahul , Kundalia Surabhi , Chandra Joshi Girish , Khanduri Sushil
Published: June 2022

204 people were killed, while two hydropower projects located in close proximity to Rini (13.2 MW) and Tapoban (520 MW) were severely damaged in Dhauliganga flood of February 7, 2021, in the Indian Himalaya. In addition, it caused massive loss of farm animals, agricultural land, property and infrastructure. This incidence occurred during the winter season when the discharge of glacier fed rivers is minimal, and the region did not experience rains around the time of the flood. Based on a detailed review of post-disaster search and rescue efforts, and bottlenecks faced by disaster managers, authors recommend (i) scientific documentation of past catastrophic events, (ii) detailed assessment of the risk posed by various hazards, (iii) legally binding disaster risk assessment, and a reduction mandate for major infrastructure projects, (iv) robust, reliable and redundant warning generation and dissemination infrastructure, (v) diversification of assets, and (vi) creating a dedicated cadre of Disaster Risk Reduction (DRR) professions.