bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Identification of Immuno- dominant B-cell Epitopes from SARS-CoV-2
Authors: Farrera-Soler Lluc , Daguer Jean-Pierre , Barluenga Sofia , Winssinger Nicolas
Published: April 2021

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current public health crisis with devastating consequences to our societies. This COVID-19 pandemic has become the most serious threat to global public health in recent history. Given the unprecedented
economic and social impact that it is causing, identification of immunodominant epitopes from SARS-CoV-2 is of great interest, not only to gain better insight into the adaptive immune response, but also for the development of vaccines, treatments and diagnostic tools. In this review, we summarize
the already published or preprinted reports on the experimental identification of B-cell linear epitopes of SARS-CoV-2 proteins. Six different epitopes leading to neutralizing antibodies have been identified. Moreover, a summary of peptide candidates to be used for diagnostic tools is also
included.
Photochemistry Meets Porous Organic Cages
Authors: Huang Hsin-Hua , Šolomek Tomáš
Published: April 2021

Chemistry of porous organic cages has developed in the past decade as an alternative to the wellknown nanoporous materials based on extended networks, such as metal organic frameworks (MOFs) or covalent organic frameworks (COFs). Unlike these extended polymeric materials, the molecular
nature of organic cages offers important advantages, such as solubility of the material in common organic solvents. However, a simultaneous combination of porosity and additional optoelectronic properties, common in MOFs and COFs, is still quite rare. Therefore, porous organic cages are relatively
underdeveloped when compared to MOFs and COFs. Here, we highlight the rich possibilities the porous organic cages offer and discuss the recent development where interesting photophysical properties augment the porosity, including our own work.
DNA-tethered Polymersome Clusters as Nanotheranostic Platform
Authors: Meyer Claire E. , Schoenenberger Cora-Ann , Liu Juan , Craciun Ioana , Palivan Cornelia G.
Published: April 2021

Nanotheranostics combine the use of nanomaterials and biologically active compounds to achieve diagnosis and treatment at the same time. To date, severe limitations compromise the use of nanotheranostic systems as potent nanomaterials are often incompatible with potent biomolecules.
Herein we emphasize how a novel type of polymersome clusters loaded with active molecules can be optimized to obtain an efficient nanotheranostic platform. Polymersomes loaded with enzymes and specific dyes, respectively and exposing complementary DNA strands at their external surface formed
clusters by means of DNA hybridization. We describe factors at the molecular level and other conditions that need to be optimized at each step of the cluster formation to favor theranostic efficiency.
Esterification Product Protection Strategies for Direct and Selective Methane Conversion
Authors: Blankenship Andrea N. , Ravi Manoj , Van Bokhoven Jeroen A.
Published: April 2021

A scale-flexible process for the direct and selective oxidation of methane to primary oxygenates is of great interest, however, a commercially feasible approach has yet to be realized due to a number of challenges. Low product yields imposed by a well-established selectivity-conversion
limit are particularly burdensome for direct methane-to-methanol chemistry. One strategy that has emerged to break out of this limit is the in situ esterification of produced methanol to the more oxidation-resistant methyl ester. However, these methaneto-methyl-ester approaches still
elude commercialization despite their unprecedented high yields. Herein, we outline some of the key barriers that hinder the commercial prospects of this otherwise promising route for highyield direct catalytic methane conversion, including extremely corrosive reagents, homogeneous catalysts,
and inviable oxidants. We then highlight directions to address these challenges while maintaining the characteristic high performance of these systems. These discussions support the efficacy of product protection strategies for the direct, selective oxidation of methane and encourage future
work in developing creative solutions to merge this promising chemistry with more practical industrial requirements.
Iron-Catalysed Remote C(sp3)-H Azidation of O-Acyl Oximes and N -Acyloxy Imidates
Authors: Leclair Alexandre , Torres-Ochoa Rubén O. , Wang Qian , Zhu Jieping
Published: April 2021

The azido group occupies an important position in modern organic chemistry, broadly used as amine surrogates and as anchors in bioconjugation. Despite their importance, examples of selective direct azidation of inert C(sp3)–H bonds remain limited and often require strong
oxidative conditions. Herein, we highlight the use of O-acyl oximes and N-acyloxy imidates as directing groups for the selective iron-catalysed azidation of C(sp3)–H bond with trimethylsilyl azide, giving access to various ?-azido ketones and ?-azido
alcohols in moderate to excellent yields. The iron catalyst is assumed to play a dual role in these catalytic processes: as a reductant to generate the reactive iminyl and imidate radicals, respectively, and as a redox centre to mediate the azido transfer to the translocated carbon radical.
The Poetry a Reflection to Hamas’s Perceptions in Its Formative Years: 1987-1993
Authors: Ben-Dror Elad
Published: April 2021

The article is a study of Hamas poetry during the period from the founding of the organization (1987) until the signing of the Oslo Accords (1993). Poetry is one of the media that Hamas employs to transmit political, social, and religious messages that fit with its worldview of Islam cum Palestinian nationalism. In its formative years, dozens of Hamas poets used this special channel to give voice to the organization’s fundamental ideas. The article looks at 11 poets who were affiliated with Hamas leadership circles and who were intensively engaged in writing poetry during those years. It describes the background to this activity, extracts the main messages and motifs raised by the verse, and examines the goals served by this lyrical composition.
Oral Iodine Supplementation in Very Low Birth Weigh Infants. Thyroid Function and Neurodevelopmental Follow Up at 24 Months. A Randomized Clinical Trial
Authors:   Neonatology Unit, University Hospital LA PAZ, Spain, S Ares , J Arnaez ,   Neonatology Unit, University Hospital LA PAZ, Spain, Rico B Saenz ,   Facultad de Educacion, Universidad Complutense, Spain, J Diez ,   Department of Biostatistics, University Hospital LA PAZ, Spain, F Omeñaca ,   Neonatology Unit, University Hospital LA PAZ, Spain, J Bernal ,   Center for Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Spain
Published: April 2021

Background: The trace element Iodine (I) is essential for the synthesis of thyroid hormones. Premature babies need >30μg I/kg/day (ICCIDD recommendations). Neonates and especially preterm infants are a population at risk of suffering the consequences of iodine deficiency, because of the impact of neonatal hypothyroxinemia on brain development. Aims: The main aim of this project is to prevent the mental retardation and increased risk of cerebral palsy of premature infants, which is partially caused by neonatal hypothyroxinemia. We gave Oral iodine supplementation in very premature babies during the neonatal period. Methods: Population: we included 94 infants born <1500g. Intervention group: we administered 30μg I/kg /day of iodine in oral drops to 47 infants from first day of life until hospital discharge. Control group: 47 infants without supplements. The study was approved by the Ethics Committee. Samples of different formulas, maternal milk was kept for the determination of the iodine content. Interventions: Blood, food and urine samples (collected at 1, 7, 15, 21, 30 days after birth and at discharge). Measurements: milk and urine for iodine determination (Benotti method). Blood samples: for thyroid hormones (T4, free T4, T3 and TSH) and tyroglobulin. Their neurological development was assessed at 2 years of age (Bayley Test). Results: Iodine content of mothers´ breast milk: 15 (5.0) μg I/dL (range 1-60); Infants in the supplemented group reached the recommendations from the first days of life. Infants in the control group did not reach the recommended intake of iodine to 60 days of life. We found a positive relation between iodine intake and the concentrations of thyroid hormones until 60 days of life. Conclusion: Thyroid function is related to iodine intake in preterm infants. Breast milk appears to be the best source of iodine for the premature infant. Preterm babies on formula preparations and with exclusive parenteral nutrition are at high risk of iodine deficiency. Therefore, supplements should be added if iodine intake is found to be inadequate. Acknowledgments. We are grateful to the Fondo de Investigaciones Sanitarias (National Grant 06/1310 for financial support).
Tall Cell Variant of Papillary Thyroid Carcinoma: Recognizing a Rare Aggressive Variant
Authors:   Department of Pathology, University of New Mexico School of Medicine, USA, Agarwal Shweta
Published: April 2021

Papillary Thyroid Cancer (PTC) accounts for 80–90% of all thyroid malignancies [1]. The most common morphology is the classical papillary which has an indolent course. Aggressive variants exist, of which Tall Cell Variant (TCV) is the most common. TCV is defined as a PTC in which 30% or more of tumor cells are 2-3 times as long as they are wide [1,2]. The histology image (Figure 1A, magnification 4x) shows tumor cells arranged back to back with abundant eosinophilic cytoplasm, and typical nuclear features of PTC; namely overlapping enlarged nuclei, intranuclear grooves, and occasional pseudoinclusions. Figure 1B (magnification: 20x) shows a high power view of the same case where the tall cell features of individual tumor cells can be better appreciated (arrows). This important feature should be recognized and reported in pathology reports as TCVs exhibit worse clinical course with extensive lymph node metastasis, extra thyroidal extension and high rate of recurrence [1,2].
Synchronous Occurrence of Hodgkin’s Lymphoma and Lung Cancer
Authors:   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey, R Erdem , F Aykas ,   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey, M Gocer ,   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey, IN Ozen ,   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey, V Aslan ,   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey, M Celik ,   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey, G Cetin ,   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey, E Kurtoglu ,   Department of Internal Medicine, Antalya Training and Research Hospital, Turkey
Published: April 2021

Hodgkin lymphoma is an uncommon neoplasm that characterized young age of onset, Hodgkin and Reed-Sternberg (HRS) cells derived from B-lymphocytes and a high cure rate, even when the patient presents with advanced metastatic spread. Lung cancer is the most common cancer worldwide and is still responsible for the most cancer deaths. We present an extremely rare case of coexisting Hodgkin lymphoma and lung cancer in a 67-year-old male patient. He initially presented with chest pain. Pet/ct revealed mass in the right lung and lymph nodes in the neck. Biopsy from the premaxillary lymph node was compatible with classical Hodgkin lymphoma. In terms of second primary malignancy, a biopsy was also performed from the mass in the right lung. Pathology showed a pulmonary adenocarcinoma and a right upper lobectomy was then performed. This patient was treated with gemcitabine plus docetaxel for lung cancer. At the end of treatment pet/ct was complete response including lymph nodes in the neck. Therefore, we did not give any treatment for Hodgkin lymphoma. The patient is still being followed up in remission.
The Effect of Hydroxychloroquine on Mortality and Pneumonia Development in SARS-Cov-2 Positive Mildly Symptomatic Outpatients without Findings of Pneumonia
Authors:   Department of Pediatrics, Hacettepe University School of Medicine, Turkey, A Kara , R Guner ,   University of Health Sciences, Ankara Metropolitan Training and Research Hospital, Turkey, S Erdinç ,   University of Health Sciences, Ankara Training and Research Hospital, Turkey, G Korukoglu ,   Turkish Ministry of Health, Virology Reference Laboratory, Ankara, Turkey, H Tezer ,   Department of Pediatrics, Gazi University School of Medicine, Turkey, A Gul ,   Istanbul Universty, Istanbul Medical School, Turkey, M Hayran ,   Department of Preventive Oncology, Hacettepe University School of Medicine, Turkey, F Temel ,   Turkish Ministry of Health, General Directorate of Public Health, Turkey, S Topal ,   Turkish Ministry of Health, General Directorate of Public Health, Turkey
Published: April 2021

Although a period longer than 10 months has passed since the detection of the first cases in and more than 40 million people have been diagnosed with COVID-19 worldwide, there is still no well-accepted and proven treatment choice for the novel coronavirus disease. This study aimed to retrospectively investigate cases in whom treatment had started due to detected as positive during screening and also having shown signs including fever, cough, shortness of breath, excessive malaise, fatigue or loss of smell-taste, without any findings of pneumonia between March 11, 2020, when the first cases were detected in Turkey, and the beginning of May, 2020. A total of 19.276 SARS-CoV-2 PCR positive outpatients, within the first 48 hours of detection and had no findings in lung auscultation or radiology, were detected from the data of Health Information System. 9559 patients were males (49.6%) and 9717 were females (50.4%). An underlying disease considered in the risk group for COVID-19 was found in 1789 of the patients (8.8%). An underlying disease was present in 9.4% using hydroxychloroquine and in 9% not using hydroxychloroquine. 43 deaths (0.2%) were detected among all cases. Mortality in cases using and not using hydroxychloroquine was respectively 5 (in 12.293 cases) and 38 (in 6.983 cases). It was confirmed that pneumonia developed in 2.080 of the patients (10.8%). This number was found as 1286 (10.5%) in cases using HQ and as 794 (11.4%) in cases not using HQ. In conclusion, since this study confirmed that hydroxychloroquine used in outpatients presenting in the early period without any symptoms of pneumonia can ensure survival and prevent pneumonia development particularly in young adults, we may speculate that the early use of hydroxychloroquine in mildly symptomatic patients results in a cost-effective and potent treatment.
Determination of Neonicotinoid Insecticides and their Metabolites, and Strobilurin Fungicides in Atmospheric Particles using Liquid Chromatography-Positive Electrospray Ionization-Tandem Mass Spectrometry
Authors:   Department of Chemistry and Biochemistry, University of Regina, Canada, A Behdarvandan , Fulton R Raina ,   Department of Chemistry and Biochemistry, University of Regina, Canada
Published: April 2021

A liquid chromatography-tandem mass spectrometry method has been developed for the simultaneous determination of metabolites of neonicotinoid insecticides with neonicotinoid insecticides and strobilurin fungicides in the particle phase fraction of atmospheric samples. Pressurized solvent extraction was used to extract the target analytes from particles collected on glass fiber filters, followed by a C18 SPE cleanup step. Recoveries of 85.9 to 108.3% and relative standard deviation <13% were obtained for all analytes. The method detection limit for metabolites of neonicotinoid insecticides were 0.5-3 ng/ mL (air concentrations of 0.44-2.66 pg/m³). Matrix effects were compensated for using standard addition calibration for quantitation. This paper provides the first detection of desmethyl-thiamethoxam which coincided with higher concentrations of thiamethoxam in atmospheric particles. Other neonicotinoid insecticides and strobilurin fungicides detected in the particle phase in the atmosphere included acetamiprid, clothianidin, imidacloprid, azoxystrobin, kresoxim-methyl, pyraclostrobin, and trifloxystrobin. This research highlights the potential of not only neonicotinoid insecticides and strobilurin fungicides moving in the atmosphere in the particle phase, but also a metabolite of thiamethoxam (desmethyl-thiamethoxam) in a region with orchards and vineyards where foliar applications with air blast sprayers dominate.
A Diagnostic Challenge: Gingival Lesions in a Postirradiated Nasopharyngeal Carcinoma Patient
Authors:   Discipline of Oral and Maxillofacial Surgery, National University Centre for Oral Health, Singapore, JHT Sng , JL Lum ,   Discipline of Oral and Maxillofacial Surgery, National University Centre for Oral Health, Singapore, CHR Loy ,   Discipline of Oral and Maxillofacial Surgery, National University Centre for Oral Health, Singapore, JF Yeo ,   Discipline of Oral and Maxillofacial Surgery, National University Centre for Oral Health, Singapore
Published: April 2021

This paper shares a diagnostically challenging case of radiation-induced sarcoma that first presented as gingival ulcerations and pain in a postradiated nasopharyngeal carcinoma patient. Insufficient information from the clinical presentation and non-specific findings from initial imaging results hindered early diagnosis. Nonetheless, correlation with medical history, prompt histopathological analysis and PET-CT imaging eventually led to a definitive diagnosis. This case report aims to increase the awareness of this uncommonly known but deadly long-term complication of head and neck radiotherapy. Clinicians ought to include radiation-induced sarcoma in their list of differential diagnosis when a patient, with a history of head and neck radiotherapy, presents with persistent gingival or oral mucosa lesions, alveolar bony exposure or other suspicious dental-related symptoms.
Combination of FTIR Spectroscopy and Chemometric Method on Quantitative Approach - A Review
Authors:   Department of Pharmaceutical Analysis, Indo-Soviet Friendship College of Pharmacy, India, K Verma , MJ Akhtar ,   Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy, India, A Anchliya ,   Department of Pharmaceutical Analysis, Indo-Soviet Friendship College of Pharmacy, India
Published: April 2021

Fourier transform infrared spectroscopy is an effectual and noncritical approach for quantitative study of different types analytes present in pharmaceutical and foodstuffs. The present review describes the basic principles and the instrumentation of FTIR spectroscopy along with its sample preparation techniques, sample handling techniques and advancements. FTIR spectroscopy in combination with chemometrics techniques has been followed over long times. The main objective of this review is to assemble the data linked to application of FTIR spectroscopic and chemometrics techniques for the quantitative study of varieties of analytes like API, adulterants, caffeine, cocaine, lipids, fats & oils, sugar and others. The FTIR spectroscopy with chemometrics techniques proved to be a beneficial methodology for quantitative study to routine analysis of these analytes.
Recent Development: Enantioselective Extraction in Chiral Separation
Authors:   Department of Chemistry, University of Mazandaran, Iran, M Hashemi , MR Hadjmohammadi ,   Department of Chemistry, University of Mazandaran, Iran
Published: April 2021

This paper discusses the recent development of enantioselective extraction methods. There are several methods in this field. The principles of all of enantioselective extraction methods are presented a focus on twophase extractions, in these methods used a chiral compound that named chiral selector, this compound distinguishes between two chiral isomers in complexation process, then one isomer more captured by chiral selector, and separation processes happen. The chiral selector should dissolve in on phase. In these methods, typical performance data are reported major emphasis on distribution ratio and enantioselectivity value or selectivity factor. In this paper, we introduce types of enantioselective extraction method, and discuss about them with several examples.
The Single E627K Amino Acid Substitution in PB2 Enhances the Pathogenicity of Wild-Bird-Origin H6N6 Subtype Avian Influenza Virus in Mice
Authors:   Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Japan, H Miura , Y Ozeki ,   Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Japan, T Omatsu ,   Research and Education Center for Prevention of Global Infectious Diseases of Animals, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan, Y Katayama ,   Research and Education Center for Prevention of Global Infectious Diseases of Animals, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan, K Imai ,   Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Japan, T Mizutani ,   Research and Education Center for Prevention of Global Infectious Diseases of Animals, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan, H Ogawa ,   Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Japan, Y Takeda ,   Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Japan
Published: April 2021

Avian Influenza Viruses (AIVs) are harbored by wild waterfowl as a natural host, and there is a species barrier restricting virus transmission from birds to mammals, including humans. However, it has been reported that, through genetic mutations, AIVs occasionally infect mammals and acquire high pathogenicity. The Amino Acid (aa) substitution of glutamic acid to lysine at position 627 (E627K) in polymerase basic protein 2 (PB2) is one of the wellknown factors underlying mammalian adaptation. Although this substitution was previously observed in mammalian-adapted H5, H7, and H9 AIV subtypes, the impact of this mutation on the mammalian adaptation of other AIV subtypes is not fully verified. Here, we isolated the low pathogenic AIV subtype H6N6 from a wild bird fecal sample in Tokachi Subprefecture, Hokkaido, Japan. We passaged this H6N6 subtype in BALB/c mice four times and acquired the mouse-adapted virus. Whole-genome sequence analysis showed that the adapted virus had only one aa substitution (E627K) in PB2. The adapted virus-inoculated mice tended to show increased weight loss and mortality compared with the original virus-inoculated mice. The viral titer in the lungs of the adapted virus-inoculated mice was significantly higher than that of the original virus-inoculated mice. Additionally, the virus isolated from the lung of the original virus-inoculated mice with serious symptoms harbored the E627K substitution. Our findings indicate the possibility that the PB2 E627K substitution in H6N6 subtype AIV rapidly appears in mammalian hosts and contributes to the enhanced pathogenicity of this virus.
Sustainable Development Goal Relational Modelling and Prediction
Authors: Alharbi Yassir , Arribas-Bel Daniel , Coenen Frans
Published: April 2021

A methodology for UN Sustainable Development Goal (SDG) attainment prediction is presented, the Sustainable Development Goals Correlation Attainment Predictions Extended framework SDG-CAP-EXT. Unlike previous SDG attainment methodologies, SDG-CAP-EXT takes into account the potential for a causal relationship between SDG indicators both with respect to the geographic entity under consideration (intra-entity) and neighbouring geographic entities to the current entity (inter-entity). The challenge is in the discovery of such causal relationships. A ensemble approach is presented that combines the results of a number of alternative causality relationship identification mechanisms. The identified relationships are used to build multi-variate time series prediction models that feed into a bottom-up SDG prediction taxonomy, which is used to make SDG attainment predictions and rank countries using a proposed Attainment Likelihood Index that reflects the likelihood of goal attainment. The framework is fully described and evaluated. The evaluation demonstrates that the SDG-CAP-EXT framework can produce better predictions than alternative models that do not consider the potential for intra- and inter-causal relationships.
Bounded Graph Pattern Matching With View
Authors: Wang Xin , Wang Yang , Zhang Ji , Zhu Yan
Published: April 2021

Bounded evaluation using views is to compute the answers $Q({\cal D})$ to a query $Q$ in a dataset ${\cal D}$ by accessing only cached views and a small fraction $D_Q$ of ${\cal D}$ such that the size $|D_Q|$ of $D_Q$ and the time to identify $D_Q$ are independent of $|{\cal D}|$, no matter how big ${\cal D}$ is. Though proven effective for relational data, it has yet been investigated for graph data. In light of this, we study the problem of bounded pattern matching using views. We first introduce access schema ${\cal C}$ for graphs and propose a notion of joint containment to characterize bounded pattern matching using views. We show that a pattern query $\sq$ can be boundedly evaluated using views ${\cal V}(G)$ and a fraction $G_Q$ of $G$ if and only if the query $\sq$ is jointly contained by ${\cal V}$ and ${\cal C}$. Based on the characterization, we develop an efficient algorithm as well as an optimization strategy to compute matches by using ${\cal V}(G)$ and $G_Q$. Using real-life and synthetic data, we experimentally verify the performance of these algorithms, and show that (a) our algorithm for joint containment determination is not only effective but also efficient; and (b) our matching algorithm significantly outperforms its counterpart, and the optimization technique can further improve performance by eliminating unnecessary input.
ВПЛИВ СОЦІАЛЬНОЇ РЕКЛАМИ ТА ЛІДЕРСЬКИХ ЯКОСТЕЙ ОСОБИСТОСТІ НА ЇЇ ПРОФЕСІЙНЕ САМОВИЗНАЧЕННЯ
Authors: Нежинська О. О.
Published: April 2021

У статті висвітлено особливості впливу соціальної реклами та лідерських якостей особистості на її професійне самовизначення. Виявлено, що сучасні різноманітні трансформації у суспільстві, а також сьогоднішні проблеми пандемії коронавірусної хвороби призвели до істотних негативних змін на ринку праці, зокрема й появи значних масштабів безробіття, соціальної незахищеності тощо, тому сьогодні вельми актуальним є пошук шляхів розв’язання окреслених проблем, покращення нинішньої ситуації, пришвидшення залучення спеціалістів до трудової діяльності тощо. Поінформовано, що проблему професійного самовизначення особистості розглядали багато відомих вітчизняних і зарубіжних дослідників. Виділено види домінантних мотивів особистості під час реалістичного вибору професії, що може бути допомогою під час діагностики в процесі профорієнтаційної роботи. Визначено психологічні особливості соціальної реклами, зокрема і вплив соціальної реклами на сприйняття особистості, тривалість процесу уваги завдяки відповідним засобам, які використовуються в рекламі. Виявлено вплив соціальної реклами на суспільство та молодь. Зафіксовано, що під час професійного самовизначення важливо розкрити власні лідерські задатки й якості, лідерський потенціал та лідерські цінності, оскільки мобілізація внутрішніх резервів допоможе особистості у повсякденній поведінці, міжособистісній комунікації, а також сприятиме збагаченню власної діяльності новими способами її виконання та підвищить особистісну ефективність загалом. Зазначено, що невміння правильно користуватися власними ресурсами, виявляти та розкривати їх можуть викликати в особистості проблеми психологічного характеру в умовах професійного самовизначення. Підкреслено, що однією з умов правильного вибору професії є профорієнтація. Констатовано, що для професійного самовизначення громадян у державі здійснюється професійна орієнтація шляхом професійного інформування, професійного консультування та професійного відбору завдяки діяльності Державної служби зайнятості.
ВИЯВЛЕННЯ ВЗАЄМОЗВ’ЯЗКІВ МІЖ КОГНІТИВНИМИ ЧИННИКАМИ АДАПТИВНОСТІ БЕЗРОБІТНИХ ПІД ЧАС КОРОТКОСТРОКОВОГО ПРОФЕСІЙНОГО ПЕРЕНАВЧАННЯ
Authors: Хубетов О. В.
Published: April 2021

Статтю присвячено дослідженню не досить освітлених у сучасному науковому просторі питань щодо впливу когнітивних чинників на рівень адаптивності безробітних при короткостроковому професійному перенавчанні, виявленню взаємозв’язків між когнітивними чинниками адаптивності та визначенню поміж цих чинників таких, рівні яких можливо змінити в процесі проведення психологічного тренінгу для позитивного впливу на рівень адаптивності. Здійснено огляд сучасних досліджень адаптивності особистості при зміні занять і життєвих ролей та факторів, що впливають на неї в різноманітних обставинах життєдіяльності. За результатами факторного аналізу, проведеного для чинників, які за попередньо проведеним кореляційним аналізом мають статистично значимі зв’язки з адаптивністю безробітних при професійному перенавчанні, виділено п’ять об’єднаних факторів. У сумі ці фактори описують 66,89 % аналізу вибірки всіх когнітивних чинників, що мають вплив на рівень адаптивності. Цими факторами є фактор інтелекту і критичного мислення, фактор самостійності та цілеспрямованості, фактор традицій і добропорядності, фактор влади, фактор творчості. Визначено критерії відбору когнітивних чинників адаптивності для комплексної програми по підвищенню адаптивності безробітних при короткостроковому професійному перенавчанні, а саме: наявність найбільших статистично значимих кореляційних зав’язків з рівнем адаптивності безробітних при короткостроковому професійному перенавчанні; можливість впливу на їх рівень за досить обмежений термін психологічного тренінгу; корекція рівнів когнітивних властивостей без втрати при цьому особистісної цілісності та можливостей саморозвитку і самовдосконалення; присутність психологічного чинника, що обирається для програми, у складі об’єднаного фактору впливу на адаптивність. Критичне мислення, особисті цінності «самостійність» та «самостійність в діяльності», творче мислення визначено чинниками, які можливо використати у комплексній програмі по підвищенню адаптивності безробітних при короткостроковому професійному перенавчанні.
Hannah Arendt – um contraponto à tradição: singularidade e responsabilidade como contestação e resistência
Authors: Costa Evandro Fonseca
Published: April 2021

Num contexto que torna tão premente e atual a exigência de contraposição ético-política à ascensão de movimentos neofascistas, a defesa da dignidade da política e da refundação do espaço público, sentido maior da obra de Hannah Arendt, conferem às noções arendtianas de singularidade e de responsabilidade os contornos da contestação e da resistência. É desde tal perspectiva interpretativo-compreensiva que neste ensaio se partilha o caminho de investigação que levou a corroboração da tese de que o entrelace de singularidade e de responsabilidade é um modo genuíno de articular uma compreensão das imbricações entre ação, pensamento e juízo em Arendt, cujos rebatimentos ético-políticos permitem entrever, em sua obra, os traços delineadores de uma ética da responsabilidade política pelo mundo.
Notas sobre a formação dos indícios formais na fenomenologia do jovem Heidegger
Authors: Caruzo Miguel Angelo
Published: April 2021

A fenomenologia heideggeriana é marcada pela busca de uma experiência que precede a oposição de sujeito e objeto. Esse processo teve início na juventude desse filósofo em seus cursos e que culminou na elaboração de seu procedimento fenomenológico conhecido como os indícios formais. A intenção desse artigo é encontrar elementos que elucidem a gênese desse processo que se encontra, em especial, no curso proferido em 1919, entre outros. Além disso, intenta-se perceber o inevitável desembocar dessa abordagem para uma das questões centrais do pensamento do jovem filósofo, que é a questão do tempo.
A Relação entre Corpo e Alma em Platão
Authors: Junior Nerivan
Published: April 2021

A pesquisa teve como objetivo explicitar duas importantes obras de Platão, Fédon e Górgias, no primeiro Platão buscará distinguir a natureza do corpo e da alma, sendo que o corpo pertence à natureza sensível estando sujeito a mudanças e sendo fonte das paixões e apetites do homem. Enquanto que a alma pertence à natureza do mundo inteligível, sendo imutável e onde o logos reside e se pode conhecer as coisas em si, ou seja, as essências das coisas. Platão também se preocupará em evidenciar a questão epistemológica, ou seja, como conhecemos as coisas e relacionando a participação da alma e do corpo nesse processo.
Objeções a interpretação de Cirne-Lima do conceito de contradição em Hegel
Authors: Costa Jaaziel De Carvalho
Published: April 2021

O texto visa, a partir do ltimo livro de Cirne-Lima, Depois de Hegel, produzir uma crtica interpretao deste autor brasileiro quanto ao conceito de contradio na filosofia hegeliana. Para isso, tomamos como base de nossa argumentao o prprio texto de Hegel - Wissenschaft der Logik - no original.
O pessimismo schopenhaueriano: Um estudo de “Sobre o sofrimento do mundo”
Authors: Mendes Viana de Oliveira André Henrique
Published: April 2021

Neste artigo tentaremos inicialmente esclarecer os conceitos centrais da filosofia schopenhaueriana, apresentados principalmente em O mundo como vontade e como representao, para em seguida analisarmos os efeitos que a tese basilar desta obra acarreta para a compreenso de alguns problemas; como o da existncia humana, o sofrimento, a negao e a afirmao da vontade de vida, entre outros que a dimenso tica comporta. Para isto, faremos uma anlise sistemtica de outros textos em que o filsofo trata diretamente destas questes, principalmente da obra Sobre o sofrimento do mundo, procurando relacionar estas duas dimenses de sua obra, buscando assim compreender a influncia da metafsica da Vontade sobre questes de cunho tico e existencial. Isto implica dizer que trataremos diretamente dos aspectos da filosofia de Schopenhauer que o tornaram conhecido como um filsofo "pessimista", sendo, portanto, tarefa nossa problematizar este rtulo a fim de evitar possveis preconceitos e concluses acrticas.
A Vida é Bela (La vita é bella de Roberto Benigni, 1998): Uma Análise deste filme à luz da Filosofia de Schopenhauer
Authors: Morais Alexander Almeida
Published: April 2021

Este artigo o resultado de uma atividade do PET-Filosofia (UFPI) denominada Cine-PET. Nesta atividade so exibidos alguns filmes e depois h uma discusso filosfica sobre o contedo dos mesmos. Neste filme La vita bella (A vida bela) , foram analisadas as idias de otimismo, iluso e representao para o querer-viver perpassadas pelo filme luz da idia de Schopenhauer sobre a Vontade como a verdadeira essncia do mundo. A Vontade, para Schopenhauer, caracterizada por ser um impulso cego, desejante e insacivel, que por isso, constitui o sofrimento e as dores de todos os seres do mundo.
A filosofia da ciência da mecânica quântica e a desconstrução da ontologia materialista
Authors: Da Silva Vinicius Carvalho
Published: April 2021

A mecnica quntica empreendeu a substituio do materialismo cientfico, por uma viso cada vez mais "formal" da natureza, dentro da qual a prpria matria seria uma conseqncia fsica de um outro estado natural que precede o nvel das partculas subatmicas, constitudo por relaes de simetrias, foras e processos, para alm das possibilidades observacionais, e ao alcance, to somente, da reflexo racional pura. Alm disto, a Fsica Contempornea trabalha com conceitos e problemas filosficos de extrema importncia, como "Causalidade", "Origem da Matria", "Constituio do Cosmos", "Limites e Possibilidades do Conhecimento", "Objetividade", e "Determinismo", de modo que uma investigao filosfica deste campo cientfico to marcado pela Filosofia, faz-se muito relevante para compreendermos a atual viso que a cincia tem da natureza e qual a filosofia subjacente fsica contempornea.
A crise dos sentidos: Modernidade Líquida e o esvaziamento da experiência sensorial
Authors: Carvalho Denis Barros de
Published: April 2021

Resumo: Este artigo discute o esvaziamento da experincia sensorial como uma das caractersticas da Modernidade Lquida, conceito criado pelo Socilogo polons Zygmunt Bauman. A crise dos sentidos ocorre pelo "silncio olfativo", pela hipertrofia da viso , tambm pelo atrofiamento da sensibilidade ttil. Somente uma reflexo sobre o embotamento da nossa experincia sensorial pode nos fazer compreender o tempo presente. Summary: This article discusses the emptying of the sensory experience as a characteristic of liquid modernity, a concept created by Polish sociologist Zygmunt Bauman. The crisis of the senses is the "silence of smell," the hypertrophy of vision and also by atrophy of tactile sensitivity. Only a reflection of the dullness of our sensory experience can make us understand the present time. Keywords: Liquid Modernity, Crisis of the senses, experience.
Rorty, Richard. Contingência, ironia e solidariedade. São Paulo: Martins, 2007.
Authors: Sousa Nayara Barros de
Published: April 2021

Resenha do livro de Richard Rorty "Contingência, ironia e solidariedade". Review of the Brazilian edition of Richard Rorty's book "Contingency, Irony, and Solidarity".
O LUGAR DAS EMOÇÕES E DOS AFETOS NA ÉTICA DA RESPONSABILIDADE DE HANS JONAS: UM CONTRASTE COM A PERSPECTIVA EMOTIVISTA/The place of emotions and affections in Hans Jonas’s ethics of responsibility: a contrast with the emotivism perspective
Authors: Oliveira Eduardo José Lima de
Published: April 2021

Mediante o assustador avanço da técnica e da ciência todas as éticas que até então estão relacionadas com este fenômeno não dão mais conta de resolver determinadas questões, pois todas as propostas éticas tradicionais são insuficientes (não inúteis) pelo fato de serem ou antropocêntricas ou imediatistas em si. O Princípio Responsabilidade que Jonas propõe visa preencher estes espaços que estas éticas tradicionais não conseguem preencher. Tomando essa proposta como referencial é que este trabalho se empenha em destacar o lugar das emoções e dos afetos dentro deste novo agir como sendo um dispositivo heurístico na proposta jonasiana, a qual é contrastada com a perspectiva emotivista.
PECORARO, Rossano. NIILISMO. Rio de Janeiro: Jorge Zahar Editor, 2007.
Authors: Silva Franklin Ferreira
Published: April 2021

Esta é uma resenha sobre o livro Niilismo do autor Rossano Pesoraro, obra introdutória sobre o niilismo, sua história, principais pontos e autores. Uma obra fundamental para quem está disposto a querer adentrar nesse assunto.
A CADERNOS DO PET FILOSOFIA EM MOVIMENTO!/Cadernos do PET Filosofia keeps moving!
Authors: Carvalho Helder Buenos Aires de
Published: April 2021

Editorial do Vol. 3, n.5, 2012.
BRUSEKE, F. J. A TÉCNICA E OS RISCOS DA MODERNIDADE. Florianópolis, UFSC, 2001.
Authors: Lima Ana Paula Araújo
Published: April 2021

...
A CONSCIÊNCIA E O EU NO PROJETO NATURALISTA DE DENNETT
Authors: Oliveira Eduardo José Lima de
Published: April 2021

Um dos grandes problemas que se estabeleceu nas discussões filosóficas, e não somente de ordem filosófica, mas também científica, é o problema da relação mente e corpo. O problema da relação “mente e corpo” teve seu momento de maior evidência no século 17 com o filósofo francês René Descartes o qual enfatizou que o homem é ser composto de duas substâncias distintas, uma material e outra imaterial. Tal pensamento tem se tornado o centro de discussões entre dualistas e monistas. Daniel C. Dennett é um monista naturalista que contrapõe firmemente a postura dualista e suas extensões. A partir do pensamento desenvolvido por Dennett é que neste trabalho procurar-se-á mostrar a impossibilidade da existência de uma substância imaterial. E ainda apontar-se-á uma possível solução sugerida por esse filósofo naturalista da mente, bem como será também colocada a importância da fundamentação de tal teoria para os estudos filosóficos e científicos na contemporaneidade. E para tal fundamentação será enfatizado o importante papel da intencionalidade e da compreensão de consciência dentro da filosofia dennettiana.
A FUNDAMENTAÇÃO METAFÍSICA DAS LEIS EM PLATÃO E SUAS IMPLICAÇÕES NORMATIVAS PARA A POLÍTICA
Authors: Lima Francisco Jozivan Guedes de
Published: April 2021

O artigo objetiva investigar a fundamentação metafísica das leis em Platão e suas implicações normativas para a política, especialmente a partir do Livro I das Leis. A tese central é que a ideia de Bem constitui o fundamento e a instância reguladora das leis que têm pretensão normativa de universalidade e justiça para a vida pública.   Abstract: The paper aims to investigate the metaphysical groundwork of the laws in Plato and its normative implications for the politics, especially from the books I of Laws. The central thesis is that the idea of Well constitutes the ground and the regulatory instance of laws that have normative claim of universality and justice for public life. Keywords: Justice, Law, Metaphysic, Politics, Plato.
O FOUCAULT DE RICHARD RORTY
Authors: Siqueira Thiago Costa Santos Carrilho
Published: April 2021

Este trabalho procura apresentar uma visão geral da perspectiva do Filósofo Richard Rorty acerca do Pensamento Foucaultiano, principalmente seu posicionamento em relação à autonomia privada e a posição dos seres humanos em relação às determinações imperativas da sociedades nas quais se incluem. Abstract: This paper tries to present a general view of the perspective of the philosopher Richard Rorty towards Michel Foucault’s thoughts, most of all his positioning about the private autonomy and the human position in front of the imperative determinations of the societies in whose they are included. Keywords: Autonomy. Power. Foucault. Society
Lançado livro TÉCNICA, MEDICINA E ÉTICA de Hans Jonas
Authors: Carvalho Helder Buenos Aires de
Published: April 2021

Tradução brasileira de importante obra do filósofo alemão Hans Jonas publicada pela Editora Paulus.
Lançado livro sobre teste histórico-dialético das tradições morais na filosofia de MacIntyre pela Editora CRV
Authors: Carvalho Helder Buenos Aires de
Published: April 2021

O livro O TESTE HISTÓRICO-DIALÉTICO DAS TRADIÇÕES DE PESQUISA MORAL NA FILOSOFIA DE ALASDAIR MACINTYRE, de João Caetanho Linhares, foi lançado pela Editora CRV. O Prof. João Caetano é docente da Universidade Federal do Maranhão e doutorando em filosofia na UFSM.
A DIALOGICIDADE NO PENSAMENTO DE PAULO FREIRE E DE HANS GEORG GADAMER e implicações na cultura escolar brasileira
Authors: Santos Maria Jesus
Published: April 2021

RESUMO: Este ensaio investiga um conceito que tem origem entre os gregos - o diálogo – e se desloca para o campo educacional brasileiro. O trabalho pedagógico de Paulo Freire e o pensamento do hermeneuta Hans Georges Gadamer constituem nossa base teórica. Deseja-se demonstrar que a dialogicidade é um elemento relevante e emancipatório e interfere na formação dos sujeitos e na construção de saberes de forma significativa. Paulo Freire na obra Pedagogia do oprimido realiza uma análise fenomenológica do cotidiano educacional e uma reflexão refinada desse processo e vai além da compreensão quando recomenda o diálogo como alternativa para um fazer pedagógico vivo e transformador. Há uma dissonância entre o que foi validado por Freire e a realidade escolar no Brasil em diferentes níveis e modalidades. Outra perspectiva que tem chamado atenção de estudiosos do campo educacional e que trata do diálogo é a Hermenêutica Filosófica de Gadamer; discute-se a possibilidade compreensiva da hermenêutica, nos moldes como fora pensado pelo hermeneuta, poder auxiliar nas bases de justificação da educação, favorecendo o debate acerca das racionalidades envolvidas no fazer pedagógico que nessa trilha parece superar os modelos de normatividade da modernidade técnico-científica, que declara o poderio da objetividade. Este estudo quer compreender a noção de diálogo vivo nesses autores e discutir sobre sua efetividade em nossos dias.
OLIVEIRA, Jelson R. Compreender Hans Jonas. São Paulo, Paulus, 2014.
Authors: Moreno Eduardo Galvão
Published: April 2021

Em “Compreender Hans Jonas”, Jelson Oliveira se propõe a apresentar de maneira clara e objetiva o longo caminho percorrido pelo alemão Hans Jonas em sua jornada filosófica, cujo ápice é a formulação da tão urgente ética da responsabilidade.  Por meio de uma ánalise cuidodadosa das obras deixadas por Jonas, Jelson confere inestimável importância a um livro único,  que torna prazeroso o conhecimento sobre o desenvolvimento intelectual do filósofo do Princípio Responsabilidade.
Um breve estudo explicativo do livro "O movimento sofista" de G.B. Kerferd
Authors: Cruz Marcilio Bezerra
Published: April 2021

A referente resenha busca fazer uma análise mais detalhada acerca do livro: "O Movimento Sofista" de George Kerferd. Objetivamos explicitar os pontos basilares ressaltados pelo autor em contrapartida a análise tradicional dos sofistas ao decorrer da história.
A OBJETIVIDADE DOS JUÍZOS MORAIS NA TEORIA ÉTICA DE JOHN RAWLS
Authors: Silva Lucas Viana
Published: April 2021

Trata do caráter objetivo dos juízos morais a partir da proposta ética de John Rawls. Inicialmente, apresenta a discussão acerca da objetividade dos juízos morais como uma questão relevante do discurso metaético contemporâneo. Em seguida, apresenta o equilíbrio reflexivo, ponto de sustentação dos juízos morais na teoria ética de John Rawls, como procedimento adequado no estabelecimento das bases para uma sociedade bem ordenada. Por fim, explicita como o equilíbrio reflexivo pode garantir objetividade aos juízos e à normatividade morais, sem recorrer ao realismo moral como fundamentação dos mesmos.Abstract: It comes to the objective character of moral judgments from the ethics proposed by John Rawls. Initially presents a discussion about the objectivity of moral judgments as an issue of contemporary metaethical discourse. It then presents the reflective equilibrium, support point of moral judgments in ethical theory of John Rawls, as proper procedure in establishing the foundations for a well-ordered society. Finally, it states as reflective equilibrium can ensure objectivity to the moral judgments and normativity without resorting to moral realism as justification for the same. Keywords: Metaethics. Moral objectivity. Moral realism. Moral judgments. Reflective equilibrium. Constructivism
Considerações sobre a folk psychology (a CIS e a TAO)
Authors: Faria Daniel Luporini
Published: April 2021

Instigados ou tocados com o belíssimo artigo escrito à quatro mãos entre Pim Haselager e González, nesta resenha crítica não só exporemos as linhas centrais de tal artigo que versa sobre uma proposta externalista da mente, levando em consideração a teoria da cognição encorporada e situada e a teoria da auto organização; também discutiremos que pensamos ser o externalismo algo muito radical (além de contra intuitivo). Neste sentido, prezamos por uma perspectiva mista: nem tão externalista, tampouco demasiada internalista.
Diurno e Noturno no pensamento de Gaston Bachelard
Authors: Machado Fernando Da Silva
Published: April 2021

O presente artigo tem por objetivo caracterizar as duas fases do pensamento bachelardiano intituladas diurna (epistemológica) e noturna (poética) e o modo como determinadas noções que permeiam as duas etapas da filosofia do autor configuram uma comunicação recíproca entre elas, fazendo com que haja uma troca assídua de valores entre ambas as vertentes. Deste modo, tentar-se-á demonstrar o quanto o fluxo de uma fase a outra de seu pensamento denota um sentido de completude ao invés de desconexão, negação ou mesmo oposição. Conceitos como descontinuidade, imagem e tempo orientarão nosso esforço em evidenciar tal complementariedade e aproximação entre as duas fases de pensamento de Gaston Bachelard.