bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Validation of a Nomogram for Post-operative Atrial Fibrillation in Off-Pump Coronary Artery Bypass Grafting
Authors: Zheng Yihan , Zhou Min , Lin Yiting , Zhang Guican
Published: December 2022

Background
The nomogram of post-operative atrial fibrillation (POAF) in off-pump coronary artery bypass grafting (OPCAB) was not established. We analyzed the incidence and individualized risk factors of POAF in participants following OPCAB and developed a prognostic nomogram for clinical practice.
Methods
Participants (n = 456) were randomly divided into training cohort (70%, n = 319) and validation cohort (30%, n = 137), and univariate and multivariate logistic regression were used to analyze the independent risk factors. In addition, we plotted DCA and CIC curves to compared with C2HEST, C2HEST, CHADS2 and CHADS2-VASc models and evaluated the clinical usefulness.
Results
Multivariable logistic regression analysis revealed that age, diabetes, hypertension, previous PCI, and intraoperative potassium were associated with POAF. Additionally, we developed nomogram with these predictors. Calibration curves calculated C-index in both training and validation cohort (0.809 and 0.886, respectively). DCA and CIC curves supported that the nomogram was superior to C2HEST, C2HEST, CHADS2 and CHADS2-VASc models and had effective clinical practice.
Conclusions
Age, diabetes, hypertension, previous PCI, and intraoperative potassium were associated with POAF. A nomogram was developed and validated to predict POAF in patients following OPCAB and provide accurate and individualized predictions.
Modeling time to stop trachoma MDA in persistent districts of Ethiopia (Comparison of cox proportional hazard regression and machine learning models)
Authors: Tefera Amsayaw , Tadesse Fentahun , Seife Fikre , Mamuye Natnael
Published: December 2022

Background
Trachoma is a serious health problem in the world's poorest countries, such as Ethiopia. The WHO aims to eliminate trachoma by 2030 through implementation of annual mass drug administration and other strategies. With almost eight years left, is Ethiopia on track to reach the goal? This research article attempts to model the time to stop MDA in one of the nations with the highest prevalence oftrachoma in the world.
Objectives
Evaluation of predictive analytic models (Cox proportional-hazards model and the random survival forest) to model the time to stop trachoma mass drug administration in persistence districts of Ethiopia and identify factors that accelerate or decelerate time to stop trachoma mass drug administration
Materials and Methods
We propose survival and machine learning models to predict the time needed to stop trachoma MDA in Ethiopia using secondary data from the Tropical Data Platform and the Trachoma Elimination Monitor Form. The impact of average mass drug administration coverage, improved latrine coverage, access to improved water, delay in MDA intervention, TF prevalence in thefirst Trachoma Impact Survey (TIS1),and MDA omission were also assessed.
Results
The result shows that the probability of districts reaching the 5% threshold varies by region, and there are also discrepancies between districts that have delayed MDA and those that have not. We also note the significant effects of MDA coverage, latrine coverage, access to water supply, initial TIS score, and MDAomission on current TF score. Ourmodel also predicts that under the existing scenarios, there are districts that will not meet the 2030 goal of eliminating trachoma.
Conclusions
In order to stop trachoma MDA or eliminate the infection efficiently and effectively, it is crucial to identify the appropriate efficacy of drug, quality of MDA coverage, frequency, timing and number of rounds of MDA. Additionally, increase environmental and hygienic conditions may accelerate progress towards 2030 goals.
A Novel Approach to Translate Structural Aggregation Queries to MapReduce Code
Authors: Abdelmoniem Ahmed , Atwa Walid , Abdulah Sameh
Published: December 2022

Data management applications are rapidly growing applications that require more attention, especially in the big data era. Thus, it is critical to support these applications with novel and efficient algorithms that satisfy higher performance. Array database management systems are one way to support these applications by dealing with data represented in n-dimensional data structures. For instance, software like SciDB and RasDaMan can be powerful tools to achieve the required performance on large-scale problems with multidimensional data. Like their relational counterparts, these management systems support specific array query languages as the user interface.Further, as a popular programming model, MapReduce allows large-scale data analysis and has also been leveraged to facilitate query processing and used as a database engine. Nevertheless, one major obstacle is the low productivity of developing MapReduce applications. Unlike the high-level declarative language such as SQL, MapReduce jobs are written in low-level descriptive language, often requiring massive programming efforts and complicated programming debugging processes.This paper presents a system that supports translating array queries expressed by AQL (Array Query Language) in SciDB into MapReduce jobs. We focus on effectively translating some unique structural aggregations, including circular, grid, hierarchical, and sliding aggregations. Unlike the traditional aggregations in relational databases, these structural aggregations are designed explicitly for array manipulation. Thus, our work can be considered an array-view counterpart of some existing SQL-to- MapReduce translators like HiveQL/Hive and YSmart. We show that our translator can effectively support structural aggregations over arrays (or sub-arrays) to meet various array manipulations. Moreover, our translator can help user-defined aggregation functions with the minimum effort of the user.We also show that our translator can generate optimized MapReduce code, leading to significantly better performance than the short hand-written code by up to 10.84X.
Efficacy and safety of denosumab de-escalation in giant cell tumor of bone
Authors: Nakata Eiji , Kunisada Toshiyuki , Fujiwara Tomohiro , Itano Takuto , Kondo Ayana , Katayama Haruyoshi , Ozaki Toshifumi
Published: December 2022

Purpose This study aims to investigate the efficacy and safety of denosumab de-escalation for giant cell tumor of bone (GCTB). Methods The medical records of nine patients with unresectable or resectable GCTB not eligible for resection who received de-escalated denosumab treatment at a single institution in 2014–2022 were retrospectively reviewed. The denosumab treatment interval was gradually extended to every 8, 12, and 24 weeks. The radiographic changes and clinical symptoms during standard and de-escalated denosumab therapy were assessed. Results The denosumab interval was de-escalated after a median of 12 months of a standard 4-weekly treatment. Imaging showed that the good therapeutic responses obtained with the 4-weekly treatment were sustained with 8- and 12-weekly treatments. GCTB treated with de-escalated denosumab therapy resulted in a complete and partial responses in one and eight patients, respectively, which were achieved with standard treatment. One patient with small femoral lesion and two patients with sacral lesion proceeded to 24-weekly treatment. Although the patient with femoral lesion had stable disease, both sacral lesions experienced tumor regrowth within 12 months. The extraskeletal masses reduced significantly with standard treatment, while tumor reduction was sustained during de-escalated treatment. The clinical symptoms improved significantly with standard treatment and remained improved during de-escalated treatment. Two patients experienced ONJ and one patient developed malignant transformation. Conclusion In conclusion, 12-weekly de-escalated denosumab treatment showed clinical benefits as a maintenance treatment in patients with unresectable GCTB, in addition to sustained stable tumor control and improved clinical symptoms with standard treatment.
A Novel Channel Selection Approach for Human Neonate’s Pain EEG Data Analysis
Authors: Talebi Safa , Frounchi Javad , Tazehkand Behzad Mozaffari
Published: December 2022

Quantitative measurement of pain using the Electroencephalogram (EEG) signals has received much attention, recently. Pain EEG data processing is associated with complexity and high computational cost. This study aims to propose a new method for selecting efficient EEG channels to determine the area of the scalp that contains the most information about brain activity during acute pain in neonates. Also, selecting relevant channels in pain assessment reduces computational costs. In this study, a new channel selection approach is proposed, which is a combination of filter and wrapper methods. A new pseudo-Sequential Forward Feature Selection (pseudo-SFFS) method is presented to reduce the computational complexity of wrapper methods. We preprocessed data by applying a bandpass filter. We used wavelet transform to extract features. After extracting the features, we applied two feature selection steps. In the first step, we applied the T-test to the extracted features. In the second step, we selected the effective channels based on the output of the applied pseudo-SFFS algorithm into Support Vector Machine (SVM), Decision Tree (DT), and Gaussian Naive Bayesian (GNB) classifiers. Using the proposed method two channels of the sensorimotor cortex including Cz and C4 channels have been selected from 18 EEG channels for pain stimulation through the left heel of neonates. Also, the results show that most of the acute pain information of neonates is related to the delta and theta frequency bands.
Functional analysis of IL-34 in diabetic ulcer healing: A bioinformatic study
Authors: Zheng Aitian , Xu Yuanyuan , Wu Biaoliang
Published: December 2022

Background: The management of diabetic foot ulcer (DFU) is a extreme clinical and social concern, and non-healingis a research hotspot. The molecular changes of non-healing but not yet clear. In this study, we primarily focused on differences between patients with healing and non-healing DFUs. We also discussed how differentially expressed genes (DEGs) in fibroblasts provide insights into pathological states of DFU healing.
Methods: Datasets of GSE166120 and GSE165816 were obtained from the Gene Expression Omnibus (GEO) database. Differential expression analyses identified the healing-related genes, and a functional enrichment analysis of DEGs was performed . Finally, we performed qRT-PCR on DFU tissue sections to confirm the findings related to DFU healing.
Results: Fibroblasts were isolated from healing and non-healing DFU according to their signature genes and then subdivided into five subpopulations based on their gene expression profiles differences. A comparison of fibroblast subpopulation characteristics revealed that the proportion of the subpopulation 4 was significantly higher in non-healing DFUs than in healing DFUs. Among the subpopulation 4, we found 254 up-regulated genes and 2402 down-regulated genes in the non-healing compared to the healing patients. An analysis of functional enrichment revealed that
DEGs perform several biological functions, including cytokine activity, receptor ligand activity, signaling receptor activator activity, and receptor regulator activity. Interleukin (IL)-34 is associated with all of these functions. IL-34 was found to be down-regulated in non-healing compared with healing DFU samples,indicating thatincreased expression of IL-34 was associated with DFU healing. In the final validation, we found that IL-34 expression was lower in patients with non-healing DFU than those with healing DFU (p＜0.05), which is consistent with the bioinformatic results.
Conclusions: IL-34 is a key factor in the healing process of diabetic foot ulcer.
Using YOLO V7 development of Complete VIDS solution based on latest requirements to provide highway traffic and incident real time info to the ATMS control room using Artificial intelligence
Authors: Patkar Uday , Shrivas Shikha Bhardwaj , Patil Uday , Songire Shubham
Published: December 2022

The authors have requested that this preprint be removed from Research Square.
Ultrasonography combined with endoscopic ultrasound-guided fine-needle aspiration to diagnosis of primary pancreatic lymphoma: a case report
Authors: Zhang Jie , Wen Hua , Du Zhaozhao , Fan Ling , Li Jie , Lu Ning , Cui Manli , Zhang Mingxin
Published: December 2022

Background
Primary pancreatic lymphoma (PPL) is an extremely rare disease with relatively non-specific clinical symptoms.It is easily overlooked and even misdiagnosed as pancreatic cancer.Clinically, we can rely on ultrasound or CT-guided aspiration for histopathological examination.These can avoid unnecessary dissection procedures and complications and reduce the lethality of lymphoma.
Case presentation
A 79-year-old woman was admitted to the hospital with "abdominal pain with cough for 1 month and worsening abdominal distension for 2 weeks".Abdominal CT/MRI: irregular soft tissue mass in the caudal region of the pancreatic body, multiple enlarged lymph nodes in the abdominal cavity and retroperitoneum, partially fused in the form of masses, metastasis was considered. Ultrasonography results: pancreatic cancer.Pathology of the abdominal mass puncture was suggestive of aggressive B-cell lymphoma.After pathological confirmation on November 20, 2021, she was transferred to the hematology department for chemotherapy with CHOP, CHOPE, and R-ESHAP regimens.She was stabilized after chemotherapy and then progressed and died in October 2022.
Conclusions
The diagnosis of PPL requires a multidisciplinary treatment model,full communication and in-depth discussion with all auxiliary and clinical departments to solve difficult problems, improve the level of treatment, promote individualized and standardized treatment of lymphoma, achieve early diagnosis and treatment, and thus reduce the mortality of lymphoma.
WITHDRAWN: Temporal Transcriptome Highlights the Involvement of Cytokine/JAK/STAT3 Signaling Pathway in the Osteoinduction of BMSCs
Authors: Ru Xiao , Cai Peian , Jin Pan , Zhong Qiuling , Huang Yuanjun , Tan Manli , Zheng Li , Lu Zhenhui
Published: December 2022

Background: Mesenchymal stem cells (MSCs)-based therapy offers an effective strategy for bone regeneration to solve the clinical orthopedic problems. However, the transcriptional regulation of multiple transitional stages of osteogenesis from MSCs has not been fully characterized.
Methods and Results: Bone marrow mesenchymal stem cells (BMSCs) stimulated with osteogenic induction media were utilized to construct the in vitro osteogenic differentiation model. BMSCs were harvested after induction for 0, 7, 14 and 21 days, respectively, to perform the mRNA-sequencing (mRNA-Seq). The transcription factor networks and common molecules during the osteogenesis were revealed by using the temporal transcriptome. Further verification was performed by the quantitative real time polymerase chain reaction (qRT-PCR) and immunofluorescence. It showed that BMSCs could differentiate into osteogenic, and crucial regulator in Cytokine/JAK/STAT3 signaling pathway including leukemia inhibitory factor (LIF), interleukin-6 (IL6)and colony stimulating factor 3 (CSF3) that modulate the phosphorylation of STAT3 were positivity associated with osteogenesis and angiogenesis.
Conclusions: Our work might provide new insights in the crucial features of the transcriptional regulation during the osteogenesis, as well as offer important clues about the activity and regulation of Cytokine/JAK/STAT3 signaling pathway in osteoinduction of MSCs.
Virtual Screening on Protein-Ligand Interactions: A pharmacological Aspect of Zingiber officinale for COVID-19 remedy
Authors: Gurisha Mikidadi S. , Jackson Alex , Rao P. V. Kanaka
Published: December 2022

With the current pandemic of the novel coronavirus disease 2019(COVID-19) in hand, researchers around the world are dexterously working to find the best suitable drug candidates and to overcome vaccination-related challenges. In Tanzania, ginger (Zingiber officinale) has been taken as a traditional remedy for COVID-19 by processing it into a different drinks. Computer-aided drug discovery provides a promising attempt to allow scientists to develop new and target-specific drugs to fight any disease. Therefore, in this study, Virtual Screening was conducted on 113 phytochemicals derived from the Zingiber officinale herb to find lead molecules for SARS-CoV-2. A total of 10 phytochemicals qualified from PyRx Virtual Screening, out of which only 5 demonstrated a substantial binding affinity with D614G SARS-CoV-2 protein, compared to remdesivir which is so far recommended by the FDA in the treatment of COVID-19. Molecular docking analysis was conducted using BIOVIA Discovery Studio, where 7BNO Open conformation of D614G SARS-CoV-2 was used as the protein receptor. The results shows that, Gingerenone A have greater binding affinity of -7.6, followed by Jyperin − 7.0, Meletin − 6.9, Isorhamnetin − 6.8 and Shogaol − 5.9. The binding affinity of remdesivir (-6.8) is less than binding affinity of Gingerenone A by 1%. These results are signifying that these phytochemicals can be used in drugs development. On the other hand, binding affinity for some of Zingiber Officinale phytochemicals derived from this study were compared with those from other studies conducted using similar approach. Equally, all selected phytochemicals demonstrated compliances with Lipinski's Rule of Five. Therefore, the present study identifies potential inhibitors of D614G SARS-CoV-2 protein for COVID 19 which needs to be validated further, both experimentally and clinically.
A Cascaded Convolutional Neural Network for Image Deblurring and Denoising
Authors: M Mahendra B , Sonoli Savita , Gowda Tarun
Published: December 2022

Although noise management has received a lot ofattention recently, image deblurring is still difficult. Imageswithout any noisy pixels are the focus of the current deblurringnetworks. To explicitly or implicitly lessen the impact of noisypixels on image deblurring, existing methods primarily relyon repetitive noise detection stages. However, these iterativeoptimization procedures and heuristic operations, which aredifficult and time-consuming, are frequently used in these noisypixels detection steps. In this paper we propose a cascaded modelof two separate networks which will handle the noisy pixelswithout any reduction in image quality. Our model aims todenoise an image first and then deblur it. In addition, it wasfound that deblurring an image first, then denoising it, producedbetter results than training a deblurring network on noisy images.Numerous tests demonstrate that this cascaded network performscompetitively in terms of PSNR and SSIM.
Mapping the research trend of PCOS: from 2006 to 2022
Authors: Zhu Jiani
Published: December 2022

Background: Multi-field specialists are required to assist in treatment. The large amount of literature on PCOS and its complex mechanism are difficult to sort out by reading the literature alone, thus we conduct a bibliometric study on PCOS, aiming to clarify the current research results of PCOS and predict the future research hotspots.Objectives: Our research aims to map the research trend of PCOS from 2006 to 2022, and help readers quickly understand its research history and future development trend.Methods: Literatures published from January 1, 2006 to June 30, 2022 were retrieved in the PubMed database, and devided into 4 periods. Of each peroid, major mesh terms/subheadings were extracted and used to conduct co-occurrence matrices and term-article matrices by Bibliographic Item Co-Occurrence Matrix Builder (BICOMB) software. The gCLUTO software was used to bicluster the term-article matrix. Social network analysis was conducted based on the word co-occurrence matrix by Gephi software.Results: From 2006 to 2010, research mainly focused on the infertility etiology and therapy of PCOS. In next period, from 2011 to 2015, research hotspots shifted to infertility drug therapy of PCOS and obesity and infertility of PCOS. After that, from 2016 to 2019, the relationship between insulin resistance and blood hormones, obesity and infertility, PCOS genetics and metabolism has attracted people's attention. In recent two years, the research of cardiovascular diseases and PCOS has become a hot topic, and epigenetics of PCOS has attracted extensive attention.Conclusions:This study well describes the research and development process of PCOS in the past 16 years, as well as the research hotspots and trends in the future.
Feasibility of 1 H MR spectroscopy in malignant pulmonary lesions at 3 Tesla: phantom study and clinical verification
Authors: Ebrahimi Marzieh , Bitarafan-Rajabi Ahmad , Paymani Zeinab , Kooranifar Siavash , Zare-Sadeghi Arash , Fard-Esfahani Armaghan , Raminfard Samira , Rohringer Taryn J
Published: December 2022

Purpose:
Primary lung malignancies are the leading cause of cancer death worldwide. In addition to primary lung malignancy, the presence of pulmonary metastases has a critical role in patient prognostication and management. Recently, cellular and molecular imaging, particularly proton magnetic resonance spectroscopy (1H MRS), has been employed for early tumor detection. This article aims to survey the role of 1H-MRS as a virtual biopsy technique to determine the biological make-up of lung lesions.
Methods:
NEMA IEC phantom analysis was utilized to acquire free induction decay (FID) of several tumor markers including choline, lactate, and creatine on single-voxel spectroscopy (SVS) at 3 Tesla (T) MRI. Various protocol modifications were performed on acquisition and processing steps. Preliminary in vivo verifications were subsequently performed on MRS datasets of 4 patients with malignant lung pathologies.
Results:
1H MRS of phantom revealed detectable peaks of choline, lactate and creatine in concentrations above the threshold of 1 µ Molar (µM) in patients with lung malignancies. Our result demonstrate that the phantom sphere diameter is the most influential factor on peak detectability with minimum reasonable value of 13mm; with the least acceptable in vitro voxel size of 1 cm3 and in vivo equivalent of 8 cm3. Trading off between acquisition time and signal to noise ratio (SNR), the appreciable number of acquisition (NAS) was equal to 64. A quantitative formula was derived to calculate metabolite concentrations (AUC=0.73). Concordant results were obtained on pilot clinical assessments.
Conclusion:
This preliminary study provides a one-stop-shop solution for SVS through optimizing acquisition and processing parameters as well as absolute quantification of choline, lactate, and creatine concentrations in malignant pulmonary lesions, with successful clinical verification.
Symptomatology and Quality of Life After Rubber Band Ligation for Haemorrhoidal Disease
Authors: Peinado Paula Pastor , Ocaña Juan , Barnó Pedro Abadía , Pérez Araceli Ballestero , Hernández Juan Diego Pina , Velasco Gloria Rodríguez , Montes Irene Moreno , Conde Elena Mendía , de Blas Estela Tobaruela , Cebrián José María Fernández , Trill Javier Die , Pérez Juan Carlos García
Published: December 2022

Purpose
The main objective of this study was to assess the impact on quality of life after rubber band ligation (RBL) in patients with symptomatic grade II-III haemorrhoids who did not improve after 6 months of conservative treatment, using quality of life scores.
Methods
This was a prospective cohort observational study where patients with haemorrhoidal disease and indication for RBL were included between December 2019 and December 2020. Patient´s quality of life was assessed by scores: HDSS (Hemorrhoidal Disease Symptom Score) and SHS (Short Health Scale), obtained by personal interview and telephone calls. Secondary objectives were: to evaluate the rate of patients requiring one or more RBL procedures, to establish the overall success rate of RBL and to analyse complications.
Results
A total of 100 patients were finally included. Regarding the impact on quality of life after RBL, a significant reduction was found in the HDSS and SHS scores (p<0.001). The main improvement was found in the first month and it was maintained until the sixth month. A high degree of satisfaction with the procedure was reported by 76% of patients. The overall success rate of banding was 89% at 18 months. A 12% complication rate was detected, the most frequent complication was severe anal pain (58.3%) and self-limiting bleeding (41.7%).
Conclusion
Hemorrhoidal RBL as a treatment for symptomatic grade II-III haemorrhoids that do not respond to medical treatment leads to a significant improvement in patients' symptoms and quality of life. It also has a high degree of satisfaction between patients.
Cascading use of renewable growing media versus peat or mineral wool: added value of biochar for end-of-life, recycling of nutrients and C storage potential
Authors: Vandecasteele Bart , Similon Lotte , Moelants Julie , Hofkens Maarten , Melis Peter , Visser Rianne
Published: December 2022

The composition of horticultural substrates for soilless greenhouse cultivation directly affects the sustainability of the cropping system but has also an indirect effect through the end-of-life of the spent media. Biochar amendment in growing media as bulk material and source of nutrients may improve the sustainability of controlled-environment agriculture. Horticultural substrates at the end of soilless strawberry and tomato cultivation were compared in 6 trials at commercial scale. Conventional mineral wool and peat-based blends were compared with peat-reduced and peat-free organic blends with or without 10 vol% biochar. Nutrients, C stability of the growing media and their value as soil improver were measured. The organic growing media had a high potential for reuse and for C storage. Spent mineral wool was significantly richer in total P, K, Mg and Ca and significantly lower in organic C content and C stability than the other blends, with a clearly lower value as soil improver than the organic blends. Biochar amendment in renewable organic blends increases its value as soil improver and the potential for reuse: adding 10 vol% biochar in the blend significantly increased the C content by 8% and the C:N ratio of the spent growing media but not the C stability. The pH of the biochar in the growing media decreased from 9.1 to 6.2 due the cultivation while the CEC increased. This research illustrates the feasibility of using biomass and biochar in cascade, i.e., first as growing medium, and finally as a C-rich soil improver.
The power law relationship between the semi-major axis and the product of the mass ratio and the square of the rotation period ratio in an eccentric system, its role and the physical mechanism of its formation
Authors: Dai Yongfeng
Published: December 2022

This study introduces the concepts of mass ratio order of magnitude and synchronous orbit radius ratio, and investigates the relationship between semi-major axis and synchronous orbit radius ratio in known systems with the same level of mass ratio order of magnitude, the same level of spin-orbit angle, and eccentric/circular orbits, including binaries, star-planet systems and planet-moon systems. Results show that in a system with an eccentric orbit (e>0.01) and a mass ratio order of magnitude greater than –7.5217, the semi-major axis has a power-law distribution relationship with the product of the mass ratio and the square of the rotation period ratio, and under conditions of spin-orbit alignment, the power-law exponent has a positive linear relationship with the mass ratio order of magnitude and is greater than 0 and less than or equal to 1. Meanwhile, this study also concludes that this power law relationship plays a decisive role in the formation of eccentric orbits. Based on Einstein’s equivalence principle and Newton’s law of gravity, this study also proposes that a moving gravitational field may exert a drag force on a mass body in the moving direction, and reveals the physical mechanism of the formation of this power law relationship. Based on such a mechanism, this study proposes that for a spin-orbit misaligned system, its power-law exponent is close to the product of the power-law exponent under conditions of spin-orbit alignment and the cosine of the spin-orbit angle.
Associations of HLA polymorphisms with anti-SARS-CoV-2 spike and neutralizing antibody titers in Japanese rheumatoid arthritis patients vaccinated with BNT162b2
Authors: Higuchi Takashi , Oka Shomi , Furukawa Hiroshi , Tohma Shigeto
Published: December 2022

Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019. Anti-SARS-CoV-2 spike (S) and neutralizing antibodies (Abs) are measured to evaluate the efficacy of vaccines. Human leukocyte antigen (HLA) may be associated with vaccine efficacy. Here, we investigated the association of HLApolymorphisms with the production of anti-SARS-CoV-2 S or neutralizing Abs in vaccinated rheumatoid arthritis (RA) patients in Japan.
Methods: Genotyping of DRB1and DQB1 was conducted in 87 Japanese RA patients vaccinated with BNT162b2. Associations of allele or haplotype carrier frequencies with anti-SARS-CoV-2 S or neutralizing Abs were examined.
Results: DRB1*12:01 was significantly positively associated with the production of S Ab (P= 0.0225, odds ratio [OR] 6.08, 95% confidence interval [CI] 1.32-28.03). The DQB1*03:01 allele carrier frequency tended to be higher in high responders of S Ab. Allele carrier frequencies of DRB1*15:01 (P= 0.0102, OR 9.26, 95% CI 1.65-52.01) and DQB1*06:02(P=0.0373, OR 7.00, 95%CI 1.18-41.36) were higher in responders of neutralizing Ab. Haplotype and two-locus analyses of DRB1 and DQB1 suggested that DRB1 alleles were the primary drivers of these associations. Logistic regression analysis showed associations of these alleles independent of clinical characteristics.
Conclusion: Independent associations were found between HLA alleles and anti-SARS-CoV-2 Ab production by vaccinated RA patients.
A Patient with Newly Diagnosed Hypertension and Pre-Existing Type 2 Diabetes Mellitus Had a Confirmed COVID-19: A Case Report and Discussion
Authors: Bereda Gudisa
Published: December 2022

COVID-19 aggravates pre-existing diabetes mellitus and contributes to newly discovered hypertension by increasing blood pressure by inhibiting the activity of angiotensin-converting enzymes 2 in the rennin-angiotensin system. Diabetes patients may be more vulnerable to COVID-19 due to chronic comorbidities such as obesity and cardiovascular disease such as hypertension. On March 23, 2022, a retired black African woman in her sixties was taken into the emergency room with the chief complaints of frequent midnight urine, hazy vision, headache, fever, and tingling in her hands and feet. A throat swab polymerase chain reaction test that revealed positive results after 28 hours was used to confirm COVID-19. Her electrocardiogram showed sinus tachycardia with a heart rate of 105 beats per minute. Fluid resuscitation (0.9% normal saline) of 1000 mL and drip insulin administration were commenced as soon as she was brought to an intensive care unit. In this case report, the patient had been previously diagnosed with type 2 diabetes mellitus. COVID-19 affects the beta cells, forcing them to release insulin and increasing the insulin insufficiency, which leads to her blood glucose raising. Type 2 diabetes mellitus is therefore the most frequent comorbidity of COVID-19 in this case report. Poor blood glucose management in the case of COVID-19 may increase the pathogen's susceptibility, the likelihood that patients will be admitted to the hospital, and the likelihood that mortality will be enhanced.
Custom Hardware and Software Integration: Bluetooth Based Wireless Thermal Printer for Restaurant and Hospital Management
Authors: Viswanatha V , A.C Ramachandra , M Sathish B , P Ashwini Kumari , R Venkata Siva Reddy , R Srinivasa Murthy
Published: December 2022

In this paper, the communication between Arduino Mega microcontroller and mini thermal printer is implemented by hardware and software integration. The microcontroller is programmed to transfer the data from microcontroller to printer using a serial communication protocol such as universal asynchronous receiver and transmitter (UART) via Serial communication devices such as MAX232 converter, DB9 connector which is nothing but RS232 serial port, and universal serial bus (USB) communication port. Data sent by the microcontroller is made to print from the printer and it is shown in the result section. Digital pins '3' and '4' on the microcontroller are used as virtual Rx and Tx serial lines while leaving the main serial port open for debugging purposes. Interfacing between UART of microcontroller, MAX232, serial port, and the USB port of printer are well established with the complete schematic diagram. The mini thermal printer prints whatever is sent by the microcontroller. A simple code similar to the one used for the serial monitor works for the printer. The baud rate needs to be set at 9600 for the microcontroller to communicate with the printer. The system is designed to print data wirelessly using Bluetooth HC-05 for restaurant and hospital management applications. The system has high adaptability. It can be used in many situations not only for restaurant and hospital management.
Automated Decision-Making with TOPSIS for Water Analysis
Authors: Javanbakht T.
Published: December 2022

This paper aims to present a new application of TOPSIS with an automated decision-making process for the analysis of drinking water. For this purpose, the algorithm was modified with a fuzzy disjunction, and the maximal output values were set to one. The properties of drinking water, such as total dissolved solids, hardness, electrical conductivity, and cost, were the criteria analyzed in this study. These criteria were analyzed with unmodified and modified algorithms. Therefore, the modified TOPSIS was also used to optimize the parameters of the candidates. The appearance of the value of 1.0 in the algorithm’s output was due to the confusion of an individual’s categories of drinking water and undrinkable water. The advantage of this investigation was that, for the first time, it allowed automated decision-making to detect the drinking water in different samples and analyze them according to their characteristics. This would be important in developing new technologies for detecting and analyzing drinking water in the environment. The results of this paper can be applied in materials sciences and engineering.
Prevention of Phytotoxic Effects of Regenerative In Situ Electrochemical Hypochlorination in Recirculating Hydroponic Systems
Authors: Lévesque Serge , Graham Thomas , Bejan Dorin , Lawson Jamie , Dixon Mike
Published: December 2022

Recirculating nutrient solutions were treated using dimensionally stable anode (DSA)-based regenerative in situ electrochemical hypochlorination (RisEHc) in a deep water culture hydroponic lettuce (Lactuca sativa) production system. Phytotoxic effects were noted and attributed to the formation of chloramines in treated nutrient solutions containing ammonium. The presence of chloramines resulted in a decrease in overhead biomass by 53% using 2.27 mA/cm2 and 83% with 4.55 mA/cm2. Adding ultraviolet light as a tertiary treatment stage allowed the photodecomposition of chloramines, which prevented phytotoxicity in crops and caused no significant differences in growth between treatments. Furthermore, using a nitrate-based fertilizer also served to prevent phytotoxic effects in crops and showed no significant differences in growth between the control and 4.55 mA/cm2. In addition, it was found that the electrochemical flow cell (EFC) treatment resulted in a 13% increase in shoot biomass using 2.27 mA/cm2. The study demonstrated that phytotoxic effects can be prevented with the use of regenerative in situ hypochlorination through proper management and monitoring techniques in recirculating hydroponic systems.
LAPAROSCOPIC VASCULAR INJURIES DURING TROCAR ENTRY IN GYNAECOLOGICAL SURGERIES
Authors:   PG Resident, Dept of OBGY SKNMCGH Pune., Shembalkar Shantanu , Lasure Shivani ,   PG Resident, Dept of OBGY SKNMCGH Pune., Darawade Sameer ,   Professor, Dept of OBGY SKNMCGH Pune.
Published: December 2022

Major vascular injuries that cause massive Haemorrhage are rare but fatal.Approaches to reduce this complication and to standardize its management are required. Most of these injuries occur at entry. There is a rise in morbidity and mortality when surgeons do notrecognize and treat these injuries early.The purpose of this study was to assess laparoscopic vascular bleeding during trocarentry and its outcome.
POWER SUPPLY FOR GREENHOUSE WITH CLEAN ENERGY FOR PLANTING VEGETABLES (ALLIUM FISTULOSUM)
Authors: Alejandro Carrera Barreto Fabian , Uchoa Yoshii Yuri
Published: December 2022

This work demonstrates the development of an automated greenhouse system with clean energy. However, these systems are expensive and not suitable for small farmers, so, in view of this, a low-cost automatic greenhouse system was developed, using an Arduino microcontroller, showing the benefits of carrying out cultivation using automated greenhouses. and how they help farmers to optimize the use of energy and water in their agricultural practices. The results obtained are very optimistic, as predicted.
NON-PHARMACOLOGICAL TREATMENT OF COGNITIVE IMPAIRMENT- AN OVERVIEW
Authors:   Junior Resident, Department of Community Medicine and Public Health, King Georges Medical University, Lucknow, UP., Pandit Pratyaksha , Kumari Reema ,   Professor, Department of Community Medicine and Public Health, King Georges Medical University, Lucknow, UP., Mishra Prabhakar ,   Additional Professor, Department of Biostatistics and Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP.
Published: December 2022

Background: With increasing proportion of geriatric population, late-life co-morbidities including dementias, heart disease, arthritis and cancers are also increasing steadily. Cognitive impairment, mainly affecting the geriatric population, is condition when a person has trouble remembering, learning new things, concentrating or making decisions that affect their everyday life, and is often considered a precursor to more serious diseases such as depression/dementia/Alzheimers disease. As per World health Organization (WHO), globally more than 55 million people live with dementia and annually 10 million new cases are added into this pool. Alzheimers Disease International estimated that world-wide 75% people with dementia remains undiagnosed and this can be as high as 90% in LMICs. Methods:The literature search utilized PubMed, Google scholar, and ResearchGate databases, with a period limit of January 2018 till November 2022. Discussion: Non pharmacological interventions (physical exercise, cognitive training, diet, meditation) have significant effect on the brain health (cognitive status) of the elderlies having cognitive impairment. Conclusions: Cognitive impairment being a complex disorder with multiple risk factor, a multimodal strategy will bring out maximum beneficial effect. Such modalities are safe, economical and simple which can be easily adapted by senior citizens and thus should be publicized to promote healthy ageing.
THE EFFECT OF OZONATION, ULTRASONIC, AND HYBRID OZONATION-ULTRASONIC PRETREATMENT METHODS ON THE DELIGNIFICATION OF OIL PALM MESOCARP FIBERS
Authors:   Department of Chemical Engineering, Faculty of Engineering, Universitas Diponegoro, Jl. Prof. H. Soedarto S.H., Semarang 50275, Indonesia., Dwi Anggoro D. , Buchori L. ,   Department of Chemical Engineering, Faculty of Engineering, Universitas Diponegoro, Jl. Prof. H. Soedarto S.H., Semarang 50275, Indonesia., Kusuma Dewi I. ,   Department of Chemical Engineering, Faculty of Engineering, Universitas Diponegoro, Jl. Prof. H. Soedarto S.H., Semarang 50275, Indonesia., Prasetyaningrum A. ,   Department of Chemical Engineering, Faculty of Engineering, Universitas Diponegoro, Jl. Prof. H. Soedarto S.H., Semarang 50275, Indonesia.
Published: December 2022

Oil palm mesocarp fiberis a by-product of the palm oil pressing process, which has great potential if used as a second-generation biofuel raw material. The main components of oil palm mesocarp fiber are cellulose, hemicellulose, and lignin commonly called lignocellulose. Cellulose is the most valuable component to be utilized in the bioenergy sector. However, the oil palm mesocarp fibers lignin layer, which binds cellulose and restricts cellulose accessibility, makes it difficult to use. Ozone pretreatment is considered to be an alternative and effective method of lignin breakdown. This study compares the ozonation, ultrasonic, and hybrid ozonation-ultrasonicmethods used to degrade lignin in oil palm mesocarp fibers. The operating conditions were set at pH (3, 4, 5, 6, 7, 8, 9, 10, 11), flow rate (1, 2, 3, 4, 5) L min-1, for (0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100) minutes, at 29Â±1 oC. The research indicates that using ozonation-ultrasonic hybridization results in a more significant degradation of lignin than using ozonation and ultrasonics individually. In this investigation, the hybrid ozonation-ultrasonic treatment gives the best lignin degradation results and the highest quantities of cellulose, reaching 91.99% after 60 minutes at a temperature of 29Â±1 oC, a pH of 9, and a flow rate of 2 L.min-1. Meanwhile, the degradation of lignin using ozone treatment is 72.75%, and ultrasound only 47.70%. Cellulose with the highest purity is 89.71%.
IMPACT OF PRANAYAMA ON DEPRESSION AMONG OLD AGED PEOPLE RESIDING AT OLD AGE HOME
Authors:   Departmentof Mental Health Nursing, State College of Nursing, Dehradun, Uttarakhand, India., Saini Deepti , Godiyal Pooja ,   Assistant Professor, Departmentof Mental Health Nursing, State College of Nursing, Dehradun, Uttarakhand, India.
Published: December 2022

Background:Life is precious gift send by the universe, but many of us live with lots of stress and tension as a result we suffer with depressive symptoms. Old age is one of the vulnerable age group that suffer from depression. Pranayama is one of the effective therapy that can be used in old age to reduce depression. Objectives: To evaluate the effectiveness of pranayama on depression among old people residing in old age home at selected area of Dist. Dehradun. Materials and method: Quasi-experimental approach with time series design was used in the study. Purposive sampling technique was used to collect data from 40 old age people with age group 60 or above from Snehasadan old age home. Result:A significant reduction in Depression with mean difference of (MD)1.075 was found significant (p= 0.001). Calculated f value is 9.63 which is greater than tabulated value 3.05 which was found significant (p=0.001). Conclusion: This study concluded that pranayama is effective in reducing depression.
A STUDY ON THE PREVALENCE OF FUNDUS CHANGES IN PREGNANCY INDUCED HYPERTENSION AMONG ANTENATAL CARE PATIENTS ATTENDING GMERS HOSPITAL, VALSAD
Authors:   DNB Resident, Department of Ophthalmology, GMERS Medical College and Hospital, Valsad, Gujarat, India., Nithaal Rajratna , Patel Mital ,   Assistant Professor, Department of Ophthalmology, GMERS Medical College and Hospital, Valsad, Gujarat, India., Chaudhari Akshay ,   Associate Professor, Department of Ophthalmology, GMERS Medical College and Hospital, Valsad, Gujarat, India., Chaudhari Pratixa ,   Associate Professor, Department of Obstetrics & Gynecology, GMERS Medical College and Hospital, Valsad, Gujarat, India., Narkhede Pushkaraj ,   DNB Resident, Department of Ophthalmology, GMERS Medical College and Hospital, Valsad, Gujarat, India.
Published: December 2022

Purpose: It was to determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the Retinal changes and age, Gravida, Parity, Blood pressure, Proteinuria and Severity of the disease. Study design: Hospital based Cross sectional study. Materials & method: All the patients admitted with a diagnosis of PIH were included in this study. Age, Gravida, Parity, Blood pressure, and Proteinuria were noted from the case record. Fundus examination was done by Indirect Ophthalmolscopy. The finding were noted and were analysed using Microsoft Excel. Result: The mean age of patients was 23.48 years. Prevalence of fundus changes in PIH is 67%. Out of 88 patients, 41 (46.59%) were the primigravida. 3 (7.31%) patients had gestational hypertension, 17 (41.46%) patients had preeclampsia, and 21 (51.21%) had eclampsia. Hypertensive retinopathies were noted in 59 (67%) patients. Retinal detachment was seen in one patient and one patient with papilloedema. There was statistically significant positive association of retinal changes with proteinuria (p= 0.0001), and severity of the PIH (p= 0.004). Conclusions: Retinal changes were seen in 67% of patients with PIH. Better antenatal care and early detection and treatment of PIH cases is needful so that there will be decrease in the chances of developing retinopathy.
LİSE ÖĞRENCİLERİNİN PSİKOLOJİK BELİRTİ VE ÖZ ŞEFKAT DÜZEYLERİNİN OKUL TÜKENMİŞLİĞİ İLE İLİŞKİSİ
Authors: DİNÇBAŞ İbrahim , GÖKKAYA Füsun , ÇIVGIN Umut
Published: December 2022

Bu araştırmanın amacı üniversite sınavına hazırlanan lise öğrencilerinin depresif belirti, anksiyete, stres belirtileri, öz şefkat ve okul tükenmişliği arasındaki ilişkilerin incelenmesidir. Üniversite sınavına hazırlanan lise öğrencilerinin hem akademik hem de yaşamsal olarak birçok sıkıntı ile yüz yüze geldikleri görülmektedir. Bu bağlamda öz şefkatin koruyucu olabileceği düşünülmektedir. İzmir ilinin Bergama ilçesindeki devlet liselerinde eğitim alan 251 öğrenci araştırmanın örneklemini oluşturmuştur. Demografik bilgi formu, Depresyon - Anksiyete - Stres Ölçeği, Öz-Anlayış Ölçeği ve Okul Tükenmişliği Ölçeği ile oluşturulan ölçek seti katılımcılar tarafından doldurulmuştur. Analizlerden önce normal dağılım varsayımları kontrol edilmiş ve veri analize hazır hale getirilmiştir. Pearson Korelasyon ve Çoklu Regresyon analizleri uygulanmıştır. Araştırma bulguları, depresif belirti, anksiyete, stres, öz şefkat ve okul tükenmişliğinin birbirleri ile ilişkili değişkenler olduğunu ve okul tükenmişliğinin depresif belirti ve stres düzeyleri tarafından yordandığını göstermiştir. Elde edilen bulgular, literatür tarafından desteklenmektedir fakat öz şefkatin okul tükenmişliğinin yordayıcısı olmaması dikkat çekmiştir. Bulgular, ilişkili literatür ışında tartışılmıştır ve gelecek çalışmalara öneriler sunulmuştur.