bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of regulatory T cells and T helper 17 cells in the pathogenesis of hypertension: a review
Authors: Muliawan Hary Sakti , Dwi Putra Swastya , Amin Hilman Zulkifli , Widyantoro Bambang
Published: February 2025

The discovery of autoantibodies in artery samples from cadavers with hypertension over 50 years ago suggested a potential link between the immune system and hypertension. Since then, research exploring the role of the immune system in hypertension has emerged. Animal studies have demonstrated a strong correlation between regulatory T cells (Tregs) and T helper 17 (Th17) cells in hypertension development, yet studies on human hypertension remain limited. Tregs produce inhibitory cytokines such as interleukin (IL)-10 and transforming growth factor-β to act as anti-inflammatory cells that protect against hypertension. In contrast, Th17 cells, by producing IL-17A, function as pro-inflammatory cells that promote hypertension. Recently, a subset of cells known as IL-17A+FOXP3+Treg cells have been identified, which can produce IL-17 and act as inflammatory cells under certain conditions. Understanding the basic mechanisms by which the immune system influences hypertension could lead to targeted immunotherapies for hypertension in the future. Thus, we highlighted the role of Tregs and Th17 cells in the development of hypertension and their potential as targets for therapy. Our findings confirmed the role of Tregs and Th17 cells in the pathogenesis of hypertension.
Fair food futures UK: Protocol for a mixed methods study exploring what approaches adopted by community food organisations are more likely to prevent the need for emergency food in two multicultural communities in Northern and Southern England
Authors: Sheard Laura , Previdoli Giorgia , Burton Wendy , Benchekroun Rachel , Power Maddy , Doherty Bob , Hadley Philip , Kapetenaki Ariadne Beatrice , Islam Shahid , Mirza Sairah , Cameron Claire , Pickett Kate , Hutton Angela , Edwards Charlotte , Bryant Maria
Published: February 2025

Introduction

Food insecurity reduces people’s chances to live healthy and active lives and places a significant burden on healthcare systems. Levels have significantly increased in the UK since 2010, due to the impact of austerity and, more recently, the COVID-19 pandemic and the cost of living crisis. This increase is projected to continue. Households with children are amongst those at highest risk for food insecurity. A variety of community food organisations (CFOs), such as community gardens, community kitchens, food banks and social markets, have been essential in responding to rising food insecurity, including providing emergency food and other types of support such as welfare advice. However, beyond food banks, little is known about differing approaches to food aid in the UK, including how these organisations provide additional services to address the underlying issue that has led someone to seek emergency food support.

Aim

To understand what approaches used by community food organisations are most likely to help prevent the need for emergency food in two multicultural communities in the North (Bradford) and South (Tower Hamlets, London) of England, with high levels of ill-health and food insecurity.

Research design, setting and participants

This is a mixed methods study informed by complex systems theory. Methods include participatory systems mapping and qualitative longitudinal research. We will map the availability and type of help with food, and produce a typology of CFO approaches, using a survey, multiple local and national participatory system mapping workshops and interviews with local and national stakeholders (WP1). Then, we will conduct a longitudinal qualitative research using a ‘researcher in residence’ approach in up to 10 CFOs purposively sampled to reflect the diversity of prevention strategies adopted by CFOs. Research will include: a) a 12 month ethnographic study; b) three waves of ‘go along’ interviews with up to 35 families; and c) a visual study where the same families are invited to share photos and videos about their food thoughts via Indeemo research app.

Outputs and dissemination

Outputs will include: a) a toolkit on CFOs to support local and national policy and implementation decisions, b) a travelling exhibition with visual representations of people’s lived experiences c) publications in academic journals, d) blog posts, e) public talks, and f) policy briefs. Findings will help decision makers to invest in the most accessible, beneficial and culturally appropriate resources for communities.
Patient-Reported Outcomes among people living with Chronic Pruritus (PROs-CP): Protocol for a single-center, multistage, mixed-methods prospective cohort study in Thailand
Authors: Nochaiwong Surapon , Ruengorn Chidchanok , Kiratikanon Salin , Rujiwetpongstorn Rujira , Chieosilapatham Panjit , Tovanabutra Napatra , Chiewchanvit Siri , Awiphan Ratanaporn , Phosuya Chabaphai , Ruanta Yongyuth , Thavorn Kednapa , Chuamanochan Mati
Published: February 2025

Background

Although there have been well-validated patient-reported outcome (PRO) measurements in dermatology practice, there is limited evidence of the adopted comprehensive aspects of PRO measures in long-term follow-up among people living with chronic pruritus. As such, we aim to create a cohort study of the Patient-Reported Outcomes among people living with Chronic Pruritus (PROs-CP) in Thailand.

Methods and design

This study is a single-center, prospective, open cohort, observational longitudinal study using a multistage, mixed-methods parallel designs to integrate both quantitative and qualitative data regarding PROs among people living with chronic pruritus (itch lasting six or more weeks). The multistage of the PROs-CP study will comprise three sub-studies: (i) study I, PROs measure development, translation, and psychometric validation; (ii) study II, perspectives of people living with chronic pruritus to gain more information regarding disease burden and unmet treatment care responses; and (iii) study III, a longitudinal study to assess the impact of chronic pruritus on long-term health outcomes. Based on a comprehensive review of a panel of stakeholders with chronic skin disease, a set of PRO measurement tools will comprise an established validated Thai version. Meanwhile, meaningful non-Thai versions or unestablished PRO instruments will be translated and developed through this study as appropriate. Quantitative data will be collected based on PRO measures regarding pruritus symptoms and severity, disease activity control and treatment satisfaction, general- and dermatology-specific health-related quality of life, mental health and psychosocial issues, and psychosomatic symptoms. Qualitative data will be obtained from the patient’s perspectives through individual interviews.

Ethics and dissemination

The study protocol was approved by the Ethics Committee of the Faculty of Medicine, Chiang Mai University (MED-2566-0299), Thailand. Our findings will be disseminated through scientific conferences and publications in peer-reviewed journals.

Conclusion

Regarding the mixed-methods approach, this open cohort, prospective longitudinal study will provide an evidence-based better understanding of patient perspectives on chronic pruritus burden and inform the utility of a comprehensive set of PROs to measure their long-term health outcomes.

Trial registration

Thai Clinical Trials Registry (TCTR, thaiclinicaltrials.org) registration TCTR20240327001 (registered on March 27, 2024).
Development of a functional electrical stimulation cycling toolkit for spinal cord injury rehabilitation in acute care hospitals: A participatory action approach
Authors: Jervis-Rademeyer Hope , Gautam Srijana , Cornell Stephanie , Khan Janelle , Wilanowski Danielle , Musselman Kristin E. , Noonan Vanessa K. , Wolfe Dalton L. , Baldini Riccardo , Kennedy Steven , Ho Chester
Published: February 2025

The purpose of our study was to develop a toolkit to facilitate the implementation of functional electrical stimulation (FES) cycling for persons with a newly acquired spinal cord injury (SCI) in the acute care inpatient hospital setting. The researchers and community members used participatory action as a research approach to co-create the toolkit. We held two focus groups to develop drafts, with a third meeting to provide feedback, and a fourth meeting to evaluate the toolkit and determine dissemination strategies. Toolkit development followed the Planning, Action, Reflection, Evaluation cycle. We used an iterative design informed by focus group and toolkit consultant (SC) feedback. In focus group discussions, we included FES cycling champions (JK, DW) who led acute care implementation. Focus group members, recruited through purposive sampling, had to 1) have an understanding about FES cycling in acute care for SCI and 2) represent one of these groups: individual living with SCI, social support, hospital manager, clinician, therapist, researcher, and/or acute care FES cycling champion. Twelve individuals took part in four focus groups to develop a toolkit designed to facilitate implementation of FES cycling in SCI acute care in Edmonton, Alberta. Group members included an individual with lived experience, three acute-care occupational or physical therapists, three acute-care hospital managers, and five researchers. Two physical therapists also identified as clinical FES cycling champions. Following an inductive content analysis, we identified four main themes: 1) Health care provider toolkit content and categories, 2) Health care provider toolkit end product, 3) Collaborations between groups and institutions and 4) Infrastructure. Interested parties who utilize FES cycling in acute care for SCI rehabilitation agree that toolkits should target the appropriate group, be acute care setting-specific, and provide information for a smooth transition in care.
Estudio experimental y numérico de materiales cerámicos procedentes de residuos de construcción y demolición
Authors: Gómez Domínguez Jesús Iñaki
Published: February 2025

Los residuos de construcción y demolición (RCDs) constituyen el mayor material de desecho, en peso y volumen, que se genera en Europa. En ellos, entre otros, se encuentran productos cerámicos, residuos de hormigón, material asfáltico y, en menor medida, componentes como madera, vidrio, plásticos y algunos otros. Se hace, por tanto, necesaria su correcta gestión de forma que se consiga reducir su impacto visual y paisajístico y aprovechar el potencial que tienen como material secundario.

La tasa de reciclaje puede ser alta con RCDs limpios de hormigón o ladrillos sin impurezas. El problema está en esa fracción más pequeña que contiene una mezcla de materiales y orígenes diferentes, lo que dificulta su reutilización. Este estudio se centra, precisamente, en la valorización de esa fracción indivisible que se amontona año tras año en las gestoras de tratamiento de residuos.

Una de las posibles soluciones que se han planteado, y que puede dar excelentes resultados en el medio plazo, es la utilización de estas fracciones finas de residuo mezclado como materia prima para la fabricación de nuevos materiales de construcción y/o tecnológicos mediante el empleo de la pulvitecnología.

Este trabajo pretende incidir en ciertos aspectos íntimamente relacionados con estos nuevos materiales, como la optimización de la molienda, la mejora del conformado, la caracterización de la resistencia a tracción del material a través del ensayo de compresión diametral o la aportación de arcillas con una doble función: mejorar la estabilidad dimensional y mejorar la circularidad del proceso empleando las granulometrías mayores que se eliminan en otros estudios.
Digest from 46th Annual Meeting of the European Thyroid Association
Authors: Kazakova M. P. , Troshina E. A.
Published: February 2025

46th Annual Meeting of the European Thyroid Association was held in September 2024 where topical issues of clinical and  scientific thyroidology were discussed. This article provides a brief overview of the event.
C-cells etiology and calcitonin/cgrp family of peptides. Literature review
Authors: Chevais A. , Bondarenko E. V. , Slashchuk K. Yu. , Ebzeeva A. K. , Vikhireva K. D. , Beltsevich D. G.
Published: February 2025

Medullary thyroid cancer (MTC) is a rare form of cancer derived from parafollicular or C cells. Currently, there is an active search for predictors of the course of MTC and markers that can predict the treatment response. Understanding the biological characteristics of the tumor requires insights from both embryology and genetics. While the genetic aspects of MTC are relatively well-studied, the embryonic origin of C-cells remains a subject of ongoing investigation. The prevailing hypothesis suggests an ectodermal origin, yet recent studies have identified the expression of markers in C-cells that are typical of cells with endodermal lineage. These data deepen the understanding of their biological role and provide reasons for further research. C-cells produce several essential hormones, including calcitonin, and possess a unique ability to synthesize and secrete other peptide hormones. This article focuses on members of the calcitonin family of hormones — calcitonin gene-related peptide, amylin, adrenomedullin, and intermedin — which regulate critical physiological processes. Some of these hormones and their receptors have been identified in malignant tumors and are associated with poorer prognosis. This review analyzes current findings on the origins of C-cells and calcitonin precursors, along with structurally similar peptides, highlighting their importance in the context of clinical oncology.
ภาวะผู้นำดิจิทัลของผู้บริหารอาชีวศึกษา ตามแนวคิดเสาหลัก 7 ประการของเอริค เชนนิเกอร์
Authors:   วิทยาลัยการจัดการ มหาวิทยาลัยพะเยา กรุงเทพมหานคร, บุษรารัตน์ ปานรดา , นิรัญทวี ศักดิ์ชัย ,   วิทยาลัยการจัดการ มหาวิทยาลัยพะเยา กรุงเทพมหานคร
Published: February 2025

บทความนี้มีวัตถุประสงค์เพื่อให้ผู้บริหารอาชีวศึกษาได้เห็นความสำคัญของภาวะผู้นำดิจิทัล ในบริบทของการบริหารสถานศึกษา ตามแนวคิดเสาหลัก 7 ประการของเอริค เชนนิเกอร์ ซึ่งองค์ประกอบที่สำคัญของภาวะผู้นำดิจิทัล คือ การสื่อสาร การประชาสัมพันธ์ การสร้างภาพลักษณ์ การมีส่วนร่วมของนักเรียน/การเรียนรู้ การเติบโตอย่างมืออาชีพและการพัฒนา การมีพื้นที่การเรียนรู้และการเสริมสร้างสภาพแวดล้อมการเรียนรู้ การสร้างโอกาส โดยผู้บริหารอาชีวศึกษาจำเป็นต้องใช้เครื่องมือดิจิทัลที่หลากหลาย แพลตฟอร์มดิจิทัลในรูปแบบต่างๆ และการใช้โซเชียลมีเดียในหลายๆช่องทาง เพื่อการบริหารอาชีวศึกษาในยุคดิจิทัลได้อย่างมีประสิทธิภาพ
ความสัมพันธ์ระหว่างคุณลักษณะของผู้สอนออนไลน์กับความพึงพอใจของผู้เรียนในหลักสูตรบริหารธุรกิจบัณทิต มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ
Authors:   คณะพัฒนาธุรกิจและอุตสาหกรรม มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ, ว่องเจริญโชควรการ กัญญ์ปภัส , กุศลาไสยานนท์ เชฐธิดา ,   คณะพัฒนาธุรกิจและอุตสาหกรรม มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ, ปิณฑะแพทย์ จุฑารัตน์ ,   คณะพัฒนาธุรกิจและอุตสาหกรรม มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ
Published: February 2025

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อ 1) ศึกษาระดับความคิดเห็นเกี่ยวกับคุณลักษณะของผู้สอนออนไลน์และระดับความพึงพอใจของผู้เรียน 2) เปรียบเทียบปัจจัยส่วนบุคคลจำแนกตามเพศ และชั้นปีที่แตกต่างกันกับความคิดเห็นเกี่ยวกับคุณลักษณะของผู้สอนออนไลน์และความพึงพอใจของผู้เรียน และ 3) ศึกษาความสัมพันธ์ระหว่างคุณลักษณะของผู้สอนออนไลน์กับความพึงพอใจของผู้เรียนในหลักสูตรบริหารธุรกิจบัณทิต มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ การวิจัยครั้งนี้เป็นการวิจัยเชิงปริมาณ กลุ่มตัวอย่างที่ใช้ในการวิจัยครั้งนี้ ได้แก่ นักศึกษาระดับปริญญาตรีหลักสูตรบริหารธุรกิจบัณฑิต มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ ที่กำลังศึกษาอยู่ในคณะพัฒนาธุรกิจและอุตสาหกรรม วิทยาเขตกรุงเทพ คณะบริหารธุรกิจ วิทยาเขตระยอง และคณะบริหารธุรกิจและอุตสาหกรรมบริการ วิทยาเขตปราจีนบุรี จำนวน 334 คน เครื่องมือที่ใช้ในการวิจัย ได้แก่ แบบสอบถาม และใช้สถิติในการวิเคราะห์ข้อมูล คือ ค่าร้อยละ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน การวิเคราะห์ความแตกต่างด้วยสถิติ t-test วิเคราะห์ความแปรปรวนด้วย F-test และค่าสัมประสิทธิ์สหสัมพันธ์ของเพียร์สัน
ผลการวิจัยพบว่า 1) ระดับความคิดเห็นเกี่ยวกับคุณลักษณะของผู้สอนออนไลน์ และระดับความพึงพอใจของผู้เรียนในระดับอุดมศึกษาของมหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ โดยรวมอยู่ในระดับมาก 2) ผลการเปรียบเทียบปัจจัยส่วนบุคคลที่แตกต่างกันกับความคิดเห็นเกี่ยวกับคุณลักษณะของผู้สอนออนไลน์ พบว่าผู้เรียนกำลังศึกษาอยู่ในชั้นปีที่ 2 มีระดับความคิดเห็นเกี่ยวกับคุณลักษณะของผู้สอนออนไลน์ โดยรวม และด้านการสอน สูงกว่าผู้เรียนที่กำลังศึกษาอยู่ในชั้นปีที่ 3 อย่างมีนัยสำคัญทางสถิติที่ระดับ 0.05 และ 3) ความสัมพันธ์ระหว่างคุณลักษณะของผู้สอนออนไลน์กับความพึงพอใจของผู้เรียนในระดับอุดมศึกษาของมหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ มีความสัมพันธ์ทางบวกอยู่ในระดับสูงมาก อย่างมีนัยสำคัญทางสถิติที่ระดับ 0.01
El papel de los convenios especiales con la Seguridad Social ante los nuevos retos del mercado de trabajo
Authors: Pérez Gázquez Isabel M.
Published: February 2025

Los convenios especiales con la Seguridad Social permiten la sujeción con el sistema de Seguridad Social a efectos de cotización y acceso a futuros derechos prestacionales, a pesar de no ejecutarse una actividad laboral o profesional. Es decir, permiten generar, mantener o ampliar los derechos ya originados ante determinadas situaciones y contingencias protegidas por el sistema.

Teniendo en cuenta que la prestación de jubilación contributiva exige periodos de carencia cada vez mayores, y que no todas las personas cuentan con la misma empleabilidad y capacidad para mantenerse o reincorporarse al mercado laboral, la obra analiza el papel y eficacia de estos convenios como instrumento para evitar la exclusión del sistema prestacional de estos colectivos vulnerables. Especialmente ante algunos de los retos actuales del mercado de trabajo como la transición digital, el aumento de la movilidad laboral transnacional, y el incremento de las personas dependientes, cuyos cuidados continuos y permanentes en ocasiones resultan incompatibles con las medidas de conciliación laboral y familiar. Asimismo, como muestra de la evolución de esta fórmula jurídica, se analiza el reciente convenio especial por prácticas formativas y prácticas académicas externas aprobado por la Orden ISM/386/2024, de 29 de abril.
Mobile Banking Adoption: Development Of the Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2) on BSI Customers in Riau Province
Authors: Mukarromah Lukluil , Setyono Joko
Published: February 2025

The rapid development of technology in the 5.0 era demands innovation to maximize the functions of technology that can be used by humans in various fields, including the banking sector, with one of its products being mobile banking. The emergence of mobile banking has shown positive impacts with numerous benefits for customers. The purpose of this research is to study important factors that can explain customers' intention and behavior in adopting mobile banking by using constructs found in the UTAUT 2 model, then adding personal innovativeness, trust, and security variables as model developments in explaining intention and behavior in adopting BSI mobile banking. The method used is quantitative, where data were collected through online questionnaires (Google Form) distributed to 360 customers who adopted BSI mobile banking services, then analyzed using structural equation modeling techniques (SEM-PLS version 3.0). The results show that the variables of price value, habit, and security have a significant positive influence on behavioral intention. Then, habit, personal innovativeness, and behavioral intention have a significant positive influence on use behavior, while effort expectancy has an influence but a significant negative effect on behavioral intention. The empirical results of this study imply that the proposed model extension has not yet been fully applied, indicating that the adoption rate still needs improvement.
Digital Consultation, Information, and Education to Enhance Knowledge and Attitudes on Hypertension
Authors: Wulandari Respati , Sifai Izzatul Alifah
Published: February 2025

Background: Hypertension is a non-communicable disease known as the silent killer. The majority of deaths from stroke and heart attacks worldwide (more than 1000 cases/hour) are caused by hypertension. This study aims to determine the increase in knowledge and attitudes about hypertension after being given an intervention in the form of digital consultation, information, and education (KIE).Method: The study employed a One-group pretest-posttest design with 36 purposively sampled respondents. It took place in Semarang from November 2023 to January 2024. Digital KIE was the intervention, delivered through WhatsApp flyers over 3 days, facilitated by a healthcare professional. Knowledge and attitudes about hypertension were measured, and data analysis utilized the Wilcoxon test.Result: The average age of respondents was 43.2 (±13.6) years, with a majority being female (75%), having a secondary education (58.3%), employed (77.8%), income > regional minimum wage (63.9%), having a family history of hypertension (63.9%), and not suffering from hypertension (75%). Findings from this study revealed an increase in respondents with good knowledge from 69.4% to 94.4% and respondents with a positive attitude from 61.1% to 80.6%. There was a significant difference in knowledge (Δ = 1; p = 0.000) and respondents' attitudes (Δ = 1.5; p = 0.020) after being provided with hypertension intervention using digital KIE. Digital KIE significantly improves knowledge and attitudes about hypertension. The implementation of digital KIE on a larger scale is expected to be a means of preventing hypertension.
Design and Development of an Interactive Sex Education Book for Kindergarten Children
Authors: Putri Paramytha Magdalena Sukarno , Masajida Nadyalis Ta'mara , Ilmiyah Chabibah , Ratih Suci Puspita , Rachmawati Windi Chusniah
Published: February 2025

Background: Kindergarten is an ideal stage to introduce comprehensive sex education, as preschool children can learn holistically. However, reproductive health materials for kindergarten students remain limited and lack comprehensiveness. This study aims to develop educational media based on the International Technical Guidance on Sexuality Education to facilitate comprehensive sexuality education at the Laboratory Kindergarten, Universitas Negeri MalangMethod: The study utilized the Borg and Gall research model. Participants included four kindergarten teachers and 63 students, divided into two grades: grade A (ages 3–4) and grade B (ages 5–6) at the Laboratory Kindergarten, Universitas Negeri Malang.Result: The results show that the majority of teachers agree that the use of sentences in the book is in accordance with Indonesian language rules, pictures, and the purpose of the book. Furthermore, the feasibility test by 4 kindergarten teachers showed that the book is very feasible (percentage of feasibility > 82.25%). The lowest eligibility score was 83.3%, while the highest score was 100%. Based on the results of the calculation of the feasibility assessment, the book is very feasible to use as a health promotion media for early childhood.
The Evolution of Adolescent Sexual Practices in Indonesia: A Longitudinal Study
Authors: Rosyida Lintang Mela , Winarni Sri , Agushybana Farid , Dharminto Dharminto
Published: February 2025

Background: Adolescents experience significant sexual and hormonal development, which may lead to engagement in premarital sexual practices. This study aims to analyze the factors associated with premarital sexual practices among adolescents in the 2007, 2012, and 2017 survey periods and to describe the trends and relevant variables identified in each period.Method: This longitudinal study utilized secondary data from the Indonesian Demographic and Health Survey (IDHS) on adolescent reproductive health. Respondents included unmarried adolescents aged 15–24 years who had completed the IDHS questionnaire. The sample sizes were 16,412 (2007), 16,998 (2012), and 19,970 (2017). Data analysis was conducted descriptively, followed by statistical analysis using logistic regression with a 95% confidence interval (CI).Result: The proportion of adolescents engaging in premarital sexual practices decreased slightly but not significantly: 5.8% in 2007, 5.4% in 2012, and 5.3% in 2017. Factors consistently associated with premarital sexual practices across all survey periods included sex, age, education level, knowledge of contraceptives, high-risk dating behaviors, and peer influence. Socialization through media and parental involvement are recommended strategies to prevent or delay premarital sexual practices.
Global solution and blow-up of critical heat equation with nonlocal interaction
Authors: Yang Minbo , Zhang Jian
Published: February 2025

We consider the Cauchy problem of the critical nonlocal heat equation

u
t

-

Δ
⁢
u

=

(

|
x
|

-
μ

∗

|
u
|

2
μ
∗

)

⁢

|
u
|

2
μ
∗

-
2

⁢
u

 

in 
⁢

ℝ
N

×

(
0
,

T
max

)

,

u_{t}-\Delta u=(|x|^{-\mu}\ast|u|^{2^{\ast}_{\mu}})|u|^{2^{\ast}_{\mu}-2}u%
\quad\text{in }\mathbb{R}^{N}\times(0,T_{\max}),

where

N
≥
3

{N\geq 3}

,

0
<
μ
<

min
⁡

{
4
,
N
}

{0<\mu<\min\{4,N\}}

and

2
μ
∗

=

2
⁢
N

-
μ

N
-
2

{2^{\ast}_{\mu}=\frac{2N-\mu}{N-2}}

is the critical exponent in the sense of the Hardy–Littlewood–Sobolev inequality.
The aim of this paper is to study the behaviour of the solutions in time. More precisely, we prove the existence and decay of global solutions and blow-up in finite time.
Furthermore, the global uniform bound of the global solutions in

H
˙

1

⁢

(

ℝ
N

)

{\dot{H}^{1}(\mathbb{R}^{N})}

and the asymptotic behaviour of them are given.
Hazard analysis of future surface displacements on active faults based on the recurrence interval of strong earthquakes
Authors: Zhou Qingyun , Liu Jingnan , Tian Peng , Luo Weidong , Bai Xianfu , Yang Yue , Zou Zhenyu
Published: February 2025

Coseismic surface displacements pose a serious threat to the safety of linear infrastructures on active faults. A reasonable evaluation of surface displacements on active faults is important. Probabilistic fault displacement hazard analysis (PFDHA) is often used for surface displacement evaluation. However, PFDHA, developed based on the classical probabilistic method, requires an in-depth study of the activity parameters of all active faults in seismic–tectonic zones, greatly limiting its application in engineering design. The recurrence interval of strong earthquakes is a readily obtainable parameter of fault activity. In this study, we combine this key parameter with various seismic indicators to develop a comprehensive algorithm to assess potential future surface displacement hazards. In addition, the factors affecting the method are analyzed, and the surface displacements of several earthquakes with a magnitude of 7 or above are compared. The results indicate that the predicted future surface displacements using our method are greater than the true displacements of seismic events. For easy use, the exceedance probability–displacement (horizontal and vertical) curves of 27 strong earthquake recurrence intervals are given. This facilitates structural designers to quickly obtain future displacement values in structural design.
Thermo-hydraulic characteristics of molten salt NaNO3–KNO3 using numerical simulations
Authors: Kudariyawar Jayaraj Y. , Sateesh K.A.
Published: February 2025

Nowadays most of research in nuclear engineering is on safety of nuclear reactor. Passive cooling attracts most of researchers to use low melting point and high boiling point fluid. Molten salts exhibit low melting and high boiling points at normal atmospheric pressure condition. These qualities make molten salts useful in a variety of applications as a coolant or heat transfer fluid. In this study, Three-dimensional (3D) Computational Fluid Dynamics (CFD) simulations have been used to examine the hydraulic properties and heat transfer characteristics of molten salt NaNO3+KNO3 (60:40 wt ratio) in a horizontal pipe. Analytical data has been used to validate computed results. A comparative analysis has been conducted between the computational results and several correlations. This helps to understand the heat transfer characteristics. Using computational data, the local Nusselt number in the heater region is determined and compared to different correlations. The thermal-hydraulic properties of molten salt obtained from CFD results are compared with existing heat transfer correlations. The most appropriate correlations for obtaining the molten salt’s thermal-hydraulic properties have been discussed. Shah and London’s correlation to determine Nusselt number predicts very well in thermally developing region compared to Churchill and Oze’s correlation. CFD results are helpful to understand the hydraulic behavior of the fluid.
Assessment of deep-learning-based resolution recovery algorithm relative to imaging system resolution and feature size
Authors: Bukka Vaidyam Veerendra Rohit , Xu Moran , Andrew Matthew , Andreyev Andriy
Published: February 2025

High-resolution X-ray microscopy is crucial for non-destructive materials characterization, but achieving both high resolution and maintaining a wide field of view often necessitates time-consuming approaches. Deep learning super-resolution methods based on convolutional neural networks are bridging this gap to obtain high-resolution usable data for analysis from low-resolution images. This study evaluates a novel deep learning-based algorithm designed to overcome traditional limitations by learning a spatially varying point spread function from a set of registered low- and high-resolution image pairs. With a systematic methodology, we evaluated the algorithm’s superior performance in recovering features across a wide range of resolutions with increasing image quality degradation. It was also benchmarked against a classical iterative Richardson-Lucy deconvolution algorithm, and a well-known deep-learning-based super-resolution convolutional neural network SRCNN algorithm for the same images. Qualitative and quantitative evaluations using simulated foam phantoms showed that our algorithm shows excellent feature recovery, within 5 % of the ground truth, even for a large resolution ratio of 7:1 between the high- and low-resolution image pairs. Multiscale investigations on real data of porous material and a semiconductor device are also presented to highlight its feature recovery performance and versatility in real-world scenarios.
Oral History Metadata and AI: A Study from an LGBTQ+ Archival Context
Authors: Cocciolo Anthony
Published: February 2025

The purpose of this study is to explore the utility of generative AI technologies in creating oral history metadata. In particular, we will explore its ability to create descriptive metadata, specifically the Dublin Core description field, for oral histories that have existing transcripts. The oral history context this research is situated in is LGBTQ+ oral histories from three repositories in the United States. Research participants with knowledge of the area of library and archival science (N=14) will rate the AI-generated description created by ChatGPT 4 compared to the description created by hand, and describe qualitatively why one is better than the other. Results indicate that users prefer the AI-generated description 51.2 % of the time, compared to preferring the descriptive metadata created by a human 26.2 % of the time and being undecided about which is preferable 21.4 % of the time. Despite research that indicates that AI can reflect the bias of the datasets used to train it, we found that the AI created culturally-appropriate content 80.4 % of time compared with 75.6 % of the time when created by a human. The use of ChatGPT 4 is recommended as a tool to analyze interview transcripts to create descriptive metadata for oral histories documenting the LGBTQ+ community, although the content should be reviewed before being provided to users.
Utilization of steel slag in concrete: A review on durability and microstructure analysis
Authors: Qureshi Hisham Jahangir , Alghamdi Saeed Abdulkhaliq , Majdi Ali , Ahmad Jawad , Rahmawati Cut , Alattyih Wael , Alzlfawi Abdullah
Published: February 2025

This study addresses the research gap in understanding the durability aspects and microstructure properties of steel slag (SS) concrete. A series of different experimental results, including porosity, water absorption, pulse velocity, carbonation depth, chloride penetration, alkali–silica reaction, acid attacks, and shrinkage, were summarized to assess the durability of SS concrete. Similarly, the pozzolanic reaction of SS, the heat of hydration, scanning electronic microscopy, and thermogravimetry were used to assess the microstructure properties of SS-based concrete. Results indicate that the SS improved the durability aspects and microstructure properties of SS concrete. However, inconsistencies in slag quality, reactivity, and expansion risks due to free lime and magnesium oxide present challenges. Finally, the review also highlights the proposed recommendation for future research.
Amino acid Gemini surfactants: a review on their synthesis, properties and applications
Authors: Zhu Sen , Liu Baowen , Wang Bin , Liu Lijuan
Published: February 2025

The modern surfactant industry demands more efficient and environmentally friendly products as environmental regulations become more stringent. Amino acid Gemini surfactants (AAGSs), as the emerging green surfactants of amino acid surfactants, together with the Geminis, which consist of two or more amphiphilic moieties chemically linked by a spacer group, are the most reliable of these efficient green chemicals. With the diversity of structure and topological configuration of the spacer group, AAGSs have stronger aggregation ability and multifarious molecular configuration and aggregation morphology. They are used in various fields such as pharmaceuticals, biomedicine, daily chemicals, oil recovery and environmental treatment. This review contains detailed discussions on the synthesis of AAGSs from natural and non-natural sources using reactions such as Hofmann alkylation and Schotten-Baumann condensation. The physicochemical properties such as low CMC, good emulsification, different micelle forms, high biodegradability, antibacterial ability and biocompatibility are presented. Future research directions of AAGSs are also suggested, including their optimized synthesis, clarification of structure-performance relationships, and exploration of new applications in a wider range of fields.
Hogyan definiálhatjuk a kirekesztést a közlekedési szektorban? A közlekedéssel kapcsolatos társadalmi és nem társadalmi kirekesztés elméleti áttekintése
Authors: Nagy Zsombor
Published: February 2025

Az emberek kapcsolata a társadalmi és gazdasági szolgáltatásokkal, rekreációs tevékenységekkel döntő szerepet játszik a mindennapi ingázók mentális és fizikai egészségében egyaránt. Emellett egyre nagyobb mértékben érzékelhető, hogy generációktól függetlenül a fenntartható közlekedési mód előnyben részesítése a már jól ismert globális és egyéni pozitív hatások mellett negatív eredményekkel is jár, mint például a mobilitásban elszenvedett veszteség. A cél egy átfogó definíció, és a közlekedéssel kapcsolatos társadalmi kirekesztést befolyásoló fő szempontok megtalálása. Jelen szakirodalmi áttekintésben a közlekedéssel kapcsolatos társadalmi kirekesztés egy elméleti irodalmi összefoglaló által kerül analizálásra 94 dokumentumot tartalmazó szöveges adatbázis segítségével, melyből végül 40 került a vizsgálat tárgya alá. Az elérhetőség és a mobilitás ezekben az irodalmakban kulcsfontosságú tényezőként reprezentálódott, amikor a közlekedéssel kapcsolatos társadalmi kirekesztést elemezték a közlekedés- és társadalomtudományban.
Analisis Nilai Karakter Wayang Punakawan sebagai Media Pembelajaran Bahasa Jawa di SD
Authors: Zuhriah Amillatuz , Nur'aini Hepy Dwi , Firmansyah Muhammad Rizky , Putri Aji Jiva Laelatul Fitri , Zulaili Iin Nur
Published: February 2025

This research aims to analyze the character values of the Punakawan wayang which then becomes a consideration for its use as a learning medium in Javanese language subjects in elementary schools. This research uses qualitative methods which are then analyzed using descriptive analysis. The results of the discussion from this research are that the use of stories from the Punakawan wayang as a learning medium will have a positive impact if the teacher can highlight the good character values of the wayang which can be emulated by students, and vice versa
Pengembangan Media Pembelajaran Video Animasi 2 Dimensi Berbasis Computing dan Slideshow Materi Cerita Rakyat Semarangan
Authors: Sholahunnisa Awalia , Insani Nur Hanifah
Published: February 2025

The impact of globalization has reduced students' appreciation of local culture, including folklores. Students' knowledge of folklore that developed in Semarang is still minimal so teachers need to apply suitable learning methods and media. The solution to the problem is to develop learning media in the form of animated videos of Semarangan folklore material. This research uses the method of Research and Development or development research. The data from this study were obtained from the needs analysis, namely teachers and students of SMP Negeri 12 Semarang using an instrument in the form of a questionnaire, and the results of validation tests from material experts and , media experts. The result of this research is that students and teachers need learning media in the form of animated audiovisual media.  The prototype of animated media was designed based on the needs analysis of students and teachers. The selection of fonts, colors is adjusted to the interests of teachers and students, namely the selection of fonts, and a combination of bright colors.  Based on the validation test results from material and media experts, the media that has been designed is included in the category that is very feasible as a learning media.
Preoperative liraglutide modulates control of fat and glucose metabolism during cardiopulmonary bypass surgery
Authors: van Wilpe Robert , Hulst Abraham H , Thiessen Steven E , DeVries J Hans , Preckel Benedikt , Hermanides Jeroen
Published: February 2025

Introduction

Glucagon-like peptide-1 receptor agonists reduce insulin requirements and improve glucose control when administered before cardiac surgery. An increase in endogenous insulin release is the most likely mechanism, but this has never been studied in the setting of cardiac surgery. We hypothesized that liraglutide increases pancreatic insulin secretion during cardiac surgery with cardiopulmonary bypass (CPB).

Methods

We performed a planned prospective substudy of a multicenter randomized-controlled trial (GLOBE trial, NTR6323). Patients undergoing cardiac surgery with CPB were randomized to receive either two preoperative subcutaneous injections of liraglutide or a matching placebo. We measured hormone concentrations before and after surgery, including insulin, glucagon, C-peptide and free fatty acid (FFA), and calculated HOMA-B, HOMA-IR and insulin/glucagon ratios. We compared between-group and before and after surgery differences in outcomes.

Results

Metabolic hormone concentrations were measured in 37 participants. HOMA-B revealed that liraglutide increased insulin secretion relative to glycemia (258 ± 179 vs 116 ± 180, difference (95% CI): 142 (24–261), P = 0.004). While insulin, C-peptide and glucagon levels did not differ significantly between groups, the insulin/glucagon ratios were significantly higher in the liraglutide group (preoperatively: 1.09 ± 0.45 vs 0.79 ± 0.35 difference (95% CI): −0.30 (−0.57 to −0.03), P = 0.039). Overall, postoperative insulin levels decreased >60% from preoperative insulin levels (55 ± 31 to 21 ± 9.8, difference (95% CI): −29 (−36 to −22), P < 0.001).

Conclusion

Preoperative liraglutide administration increased beta-cell function, measured as HOMA-B, and higher insulin/glucagon ratios. These results could explain the lower glucose and FFA concentrations in the liraglutide-treated patients. Interestingly, in both groups, we observed a remarkable drop in insulin and other hormone levels over the course of surgery.
The Use of the Istinbathiyah Method in Learning the Ma’ani (Balaghah) Using Mutasyabihat fi al-Alfadz Verses
Authors: Hasim Muhamad Fuad , Baihaqi Muhammad , Fatihuddin Fatihuddin , Mahditama M. Rajib , Fuadhi Muhammad Iqbal
Published: February 2025

Balaghah is a branch of Arabic literature that is very important for understanding the meaning of ijaz in the Qur'an. Balaghah is also a science taught in Islamic boarding schools, so it is very important to know the effectiveness of its learning methods. This study aims to determine the effectiveness of the Istinbathiyah method in learning Ma'ani (balaghah). The research method in this study is quantitative with an experimental type. Data collection was carried out by conducting observations, documentation, and tests. Data analysis was carried out statistically, the formula used was the t-test formula or t-test. There are several requirements that must be met before the t-test is carried out, including the Normality test, Homogeneity Test, and Hypothesis Test. The results of this study indicate that the Istinbathiyah method is quite effective with an average value of 16.3 from the control class while 66.9 from the experimental class.
Resistência e organização popular
Authors: Kronemberger Adriana Bastos
Published: February 2025

Este estudo constitui uma parte da minha investigação de doutorado realizada na Pontifícia Universidade Católica de São Paulo (PUC-SP) em 2023, centrada na análise dos movimentos sociais urbanos que emergiram durante as décadas de 1970 e 1980 em Nova Iguaçu, cidade do estado do Rio de Janeiro, Brasil. Os movimentos sociais urbanos surgiram como resposta às injustiças sociais e eram estreitamente conectados com a Igreja Católica adepta da Teologia da Libertação. O estudo investigou a preservação da memória dessas lutas, objetivando compreender as percepções dos militantes sobre suas participações e a resistência à ditadura civil-militar. Utilizando a metodologia de História oral e uma abordagem da análise de discursos, objetivou-se analisar tanto as falas dos entrevistados quanto os documentos escritos. O resgate dessas lutas sociais não apenas honra o passado, mas também pode inspirar ações sociais futuras em favor dos direitos básicos e da dignidade da população.
Mutation in the HvBRI1 and HvCPD genes involved in brassinosteroid biosynthesis/signalling enhances de-acclimation tolerance of barley
Authors:   University of Agriculture in Krakow, Pociecha Ewa , Wójcik-Jagła Magdalena ,   University of Agriculture in Krakow, Daszkowska-Golec Agata ,   University of Silesia in Katowice, Grzesiak Maciej ,   The Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, Gruszka Damian ,   The Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, Janeczko Anna ,   The Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences
Published: February 2025

This dataset presents the results of a research which aimed to find out how mutation in the HvBRI1 and HvCPD genes affects the signalling and synthesis of brassinosteroids, and in consequence, influences de-acclimation tolerance of barley. We verified a hypothesis that temperature-dependent changes in the expression of selected genes contribute to de-acclimation tolerance. This study was aimed to identify the mechanisms responsible for differences between mutants and their reference cultivar – Bowman.
Pseudoartrosis diafisiaria femoral de presentación atípica, reporte de caso clínico
Authors: Ornelas Miranda Alonso Josue , Padua Koelliker Alejandro
Published: February 2025

Las fracturas de fémur pueden comprometer tanto la integridad estructural como la funcionalidad del miembro inferior, siendo común la asociación con lesiones en partes blandas, hemorragia significativa y riesgo de síndrome compartimental. Tienen una incidencia de 10-37 casos por cada 100,000 personas al año. Las fracturas diafisiarias son más comunes en hombres jóvenes debido a la mayor ocurrencia de traumatismos de alta energía.Respecto a la no unión existe una tasa de pseudoartrosis después del enclavado intramedular inferior al 5%, esta se define como una fractura de al menos 9 meses de evolución la cual no ha mostrado evidencia de consolidación por 3 meses consecutivos. Se presenta el caso clínico de un paciente masculino de 21 años con diagnóstico de fractura femoral diafisiaria secundaria a accidente en vehículo de motor de alta energía, donde colisiona contra automóvil y a quien se le practican 3 intervenciones quirúrgicas, tras las que el paciente queda en estatus de no unión tras colocación de clavo femoral distal, posteriormente se realiza intervención con clavo femoral proximal evidenciándose consolidación en radiografías de control
Barriers experienced by Stroke survivors when participating in meaningful occupations in the community
Authors: Mohotlhoane Refilwe , Nemakanga Mashudu Norman
Published: February 2025

Introduction: There are various personal and environmental factors that hinder the stroke survivors’ participation in meaningful occupations within a rural and semi-rural community context. Thus, occupational therapists need to consider such barriers in order to provide holistic treatment.
Aim: This study intended to explore the barriers experienced by stroke survivors on their participation in meaningful occupations in a rural and semi-rural community.
Method: An explorative qualitative study was conducted, using a purposive sampling method to recruit participants at a public healthcare district hospital. Data were collected at the participants’ homes using individual semi-structured interviews. The researcher made use of open-ended questions guided by the Occupational Therapy Practice Framework 3rd edition and the Person Environment Occupation Performance model.
Findings: Four themes related to the barriers experienced by stroke survivors on their participation in meaningful occupations emerged: (i) physical barriers, (i) psychological barriers, (iii) financial and (iv) environmental barriers.
Conclusion: The barriers explored in this study compelled the stroke survivors to accept varying degrees of assistance from their caregivers. The findings of this study could assist occupational therapists to consider the factors that hinder the stroke survivors’ participation in meaningful occupations in rural and semi-rural South African communities, and inform treatment aims that are relevant to the respective communities. If occupational therapists consider these barriers when planning treatment, this could assist with maximizing in- dependence in all areas of stroke survivors’ lives, lessening the burden of care on their caregivers and decreasing the patient load on clinical and community occupational therapists.
Implications for practice
Stroke survivors dwelling in the semi-rural and rural community contexts experience barriers which are unique to such settings. Thus, occupational therapist should be aware of the differences of barriers experienced not only in the hospital setting, but in the community context that stroke survivors are reintegrated to. Such consideration could contribute to intervention focussed on the individual’s specific needs with regard to participation in meaningful occupations within the semi-rural and rural contexts they reside in.
Total Robotic Resection of Ascending Duodenal Gastrointestinal Stromal Tumor using Tubular Stapler Anastomosis: A Case Report
Authors: Zuo Shengzhe , Jinhao Peng , Huang Guanda , Liao Xiaofeng , Zhang Yongkang
Published: February 2025

An obese patient was admitted to the Department of Gastrointestinal Surgery at Xiangyang Central Hospital, an affiliated hospital of Hubei University of Arts and Sciences, in June 2024 due to a gastrointestinal stromal tumor (gastrointestinal mesothelioma) of the ascending duodenum. Complete robotic excision of the gastrointestinal stromal tumor and tubular stapler insertion into the ascending duodenum were carried out. The surgeries took 190 minutes (the docking time was 30 minutes), there were approximately 10 milliliters of intraoperative hemorrhage, and there was no duodenal stenosis or contrast agent leak on the upper gastrointestinal tract. The outcomes demonstrated the technical safety and viability of using a tubular stapler to treat ascending duodenums under a total robot, as well as offering some experience in the selection of surgical techniques for GIST in specific segments.