bluuebunny/crossref_metadata_2025 huggingface dataset:
Translation defects in ribosomopathies
Authors: Boussaid Ismael , Fontenay Michaela
Published: February 2022

Purpose of review

Congenital or acquired ribosomopathies related to mutations or deletions in ribosomal proteins gene or ribosome-associated proteins exhibit defective ribosome biogenesis that expose the cell to translation defects. The mechanisms leading to low translation rate, loss-of-translation fidelity and translation selectivity are reviewed.

Recent findings

New quantitative techniques to measure ribosome component stoichiometry reveal that the pool of ribosomes could be heterogeneous and/or decreased with a limited number of translationally competent ribosomes. During development or cell differentiation, the absence of specific ribosome components or their replacement by paralogs generate heterogeneous ribosomes that are specialized in the translation of specific mRNAs. Decreased ribosome content by defective biosynthesis of a subunit results in translation selectivity at the expense of short structured transcripts with high codon adaptation index. Activation of p53, as a witness of nucleolar stress associated with the hematological phenotype of ribosomopathies participates in translational reprogramming of the cell by interfering with cap-dependent translation.

Translation selectivity is a common feature of ribosomopathies. p53 is more selectively activated in ribosomopathies with erythroid phenotype. The discovery of its dual role in regulating transcriptional and translational program supports new therapeutic perspectives.
Sarcopenia and its impact in head and neck cancer treatment
Authors: de Bree Remco , van Beers Maartje A. , Schaeffers Anouk W.M.A.
Published: February 2022

Purpose of review

The aim of this review is to discuss recent studies on the assessment of sarcopenia and its predictive and prognostic value in head and neck cancer (HNC) patients.

Recent findings

There is increasing evidence that low skeletal muscle mass (SMM), often named sarcopenia, can easily be assessed on cross-sectional imaging of the head and neck and is associated with chemotherapy (dose limiting) and radiotherapy toxicity and survival.

SMM measurement at the level of the third cervical vertebra (C3) on routine computed tomography and magnetic resonance imaging is easy and robust to perform. Several studies have shown a significantly higher incidence of cisplatin dose limiting toxicity in HNC patients with a low SMM. In HNC patients pretreatment low SMM is associated with acute and late toxicity and adverse events of radiotherapy, complications of major head and neck surgery and decreased disease-specific and overall survival. This information can be used for individualized treatment planning in HNC patients with low SMM.
Artificial intelligence in endourology: emerging technology for individualized care
Authors: Dai Jessica C. , Johnson Brett A.
Published: February 2022

Purpose of review

Artificial intelligence in medicine has allowed for efficient processing of large datasets to perform cognitive tasks that facilitate clinical decision-making, and it is an emerging area of research. This review aims to highlight the most pertinent and recent research in artificial intelligence in endourology, where it has been used to optimize stone diagnosis, support decision-making regarding management, predict stone recurrence, and provide new tools for bioinformatics research within endourology.

Recent findings

Artificial neural networks (ANN) and machine learning approaches have demonstrated high accuracy in predicting stone diagnoses, stone composition, and outcomes of spontaneous stone passage, shockwave lithotripsy (SWL), or percutaneous nephrolithotomy (PCNL); some of these models outperform more traditional predictive models and existing nomograms. In addition, these approaches have been used to predict stone recurrence, quality of life scores, and provide novel methods of mining the electronic medical record for research.

Artificial intelligence can be used to enhance existing approaches to stone diagnosis, management, and prevention to provide a more individualized approach to endourologic care. Moreover, it may support an emerging area of bioinformatics research within endourology. However, despite high accuracy, many of the published algorithms lack external validity and require further study before they are more widely adopted.
Assessing Long-Term Outcomes in Breast Implant Illness: The Missing Link? A Systematic Review
Authors: Rohrich Rod J. , Bellamy Justin L. , Alleyne Brendan
Published: February 2022

The purpose of this special topic article is to explore the current state of outcomes-based literature related to breast implant illness and summarize the key understandings that emerge from the summation of existing studies. While implanted silicone devices are some of the most ubiquitous products in modern medicine, the safety of silicone breast implants has long remained under scientific scrutiny. In the era of social media and with breast implants once again under public scrutiny with the recent connection of texture silicone implants to breast implant–associated anaplastic large-cell lymphoma, the borders between breast implant illness and other implant-related diseases are becoming clouded in the public eye. The surgical management options for breast implant illness range from simple implant explantation alone to complete en bloc capsulectomies, or even secondary exploratory operations for additional capsulectomy in persistently symptomatic patients. In this review of outcomes-based studies related to breast implant illness, the authors found that a subset of patients improves with surgical intervention but limited evidence to inform most current surgical management practices. Further, the nature of this illness renders it difficult to study. A carefully designed, large, prospective, outcomes-based study is still required if an evidence-based and sound treatment approach for this condition is to be established.
Clinical and Kidney Structural Characteristics of Living Kidney Donors With Nephrolithiasis and Their Long-term Outcomes
Authors: D’Costa Matthew R. , Merzkani Massini A. , Denic Aleksandar , Mullan Aidan F. , Larson Joseph J. , Kremers Walter K. , Park Walter D. , Alexander Mariam P. , Chakkera Harini A. , Taler Sandra J. , Erickson Stephen B. , Stegall Mark D. , Issa Naim , Rule Andrew D.
Published: February 2022

Background.

Nephrolithiasis in living kidney donors is concerning due to the potential impact on long-term postdonation kidney function.

Methods.

We performed a cohort study of living kidney donors from 2 centers with a baseline computed tomography scan and implantation renal biopsy. Donors (>5 y since donation) completed a follow-up survey or underwent chart review to assess eGFR and incident hypertension. Stone formers were classified as symptomatic if they had a past symptomatic episode or asymptomatic if only incidental radiographic kidney stones were identified during donor evaluation. We compared baseline clinical, imaging, and biopsy characteristics by stone former status including review of metabolic evaluations in stone formers. Long-term risks of renal complications (low eGFR and hypertension) by stone former status were evaluated.

Results.

There were 12 symptomatic and 76 asymptomatic stone formers among 866 donors. Overall, baseline clinical characteristics and implantation biopsy findings were similar between stone formers and non-stone formers. After a median follow-up of 10 y, stone former status was not associated with eGFR <60 mL/min/1.73 m2, eGFR <45 mL/min/1.73 m2, or hypertension.

Conclusions.

Both asymptomatic and symptomatic SF have favorable histology findings at baseline. Long-term kidney outcomes were favorable in select stone formers with no evident increased long-term risk for decreased kidney function or hypertension after donation.
New and emerging pharmacologic treatments for developmental and epileptic encephalopathies
Authors: Vasquez Alejandra , Buraniqi Ersida , Wirrell Elaine C.
Published: February 2022

Purpose of review

Summarize evidence on Developmental and Epileptic Encephalopathies (DEEs) treatments focusing on new and emerging pharmacologic therapies (see Video, http://links.lww.com/CONR/A61, Supplementary Digital Content 1, which provides an overview of the review).

Recent findings

Advances in the fields of molecular genetics and neurobiology have led to the recognition of underlying pathophysiologic mechanisms involved in an increasing number of DEEs that could be targeted with precision therapies or repurposed drugs, some of which are currently being evaluated in clinical trials. Prompt, optimal therapy is critical, and promising therapies approved or in clinical trials for tuberous sclerosis complex, Dravet and Lennox–Gastaut Syndromes including mammalian target of rapamycin inhibitors, selective membrane channel and antisense oligonucleotide modulation, and repurposed drugs such as fenfluramine, stiripentol and cannabidiol, among others, may improve seizure burden and neurological outcomes. There is an urgent need for collaborative efforts to evaluate the efficacy and safety of emerging DEEs therapies.

Development of new therapies promise to address unmet needs for patients with DEEs, including improvement of neurocognitive function and quality of life.
Exploring the vagus nerve and the inflammatory reflex for therapeutic benefit in chronic spinal cord injury
Authors: Bloom Ona , Tracey Kevin J. , Pavlov Valentin A.
Published: February 2022

Purpose of review

To describe features and implications of chronic systemic inflammation in individuals with spinal cord injury (SCI) and to summarize the growing therapeutic possibilities to explore the vagus nerve-mediated inflammatory reflex in this context.

Recent findings

The discovery of the inflammatory reflex provides a rationale to explore neuromodulation modalities, that is, electrical vagus nerve stimulation and pharmacological cholinergic modalities to regulate inflammation after SCI.

Inflammation in individuals with SCI may negatively impact functional recovery and medical consequences after SCI. Exploring the potential of the vagus nerve-based inflammatory reflex to restore autonomic regulation and control inflammation may provide a novel approach for functional improvement in SCI.
Lamotrigine-induced mania: warning report for the identification of vulnerable populations and expert clinical recommendations for prescription
Authors: Anmella Gerard , Pacchiarotti Isabella , Hidalgo-Mazzei Diego , Fico Giovanna , Murru Andrea , Sagué-Vilavella Maria , Amoretti Silvia , Verdolini Norma , Radua Joaquim , Vieta Eduard
Published: February 2022

Lamotrigine (LTG) is an anticonvulsant drug used for the prevention of depressive episodes in bipolar disorder (BD) that might induce manic episodes in some cases. A 38-year-old man, stabilized with asenapine due to a brief psychotic episode, presented depressive symptoms and LTG was titrated up to 200 mg/day in 6 weeks. One week later he was diagnosed with a first manic episode with psychotic symptoms [Young Mania Rating Scale (YMRS = 31)] and type I BD (BD-I). LTG was withdrawn and he was treated with lithium and lurasidone. The episode remitted in 1 week. A 45-year-old woman with BD presented persistent depressive symptoms and received LTG 25 mg/day. After 3 weeks she was diagnosed with a manic episode with psychotic symptoms (YMRS = 35). LTG was suspended and aripiprazole increased. The episode remitted within 10 days. Both patients remained euthymic with no further episodes after 1-year follow-up. The propensity of LTG to induce manic episodes may be related to its lack of antimanic effects, along with its antidepressant properties, probably related to decreased glutamate release. Secondary analyses from LTG randomized clinical trials have excluded subjects with higher vulnerability to manic switches so that the risk of LTG-induced mania might have been underestimated. LTG-induced mania may be more likely to happen in patients with BD-I, manic predominant polarity, an index manic episode, or those with a history of the antidepressant manic switch. Therefore, in BD patients with the aforementioned risk factors, LTG use should be carefully managed: starting with low doses, extending tapering lengths, using adjunctive treatments and close monitoring manic symptoms.
Arthrobacter sunyaminii sp. nov. and Arthrobacter jiangjiafuii sp. nov., new members in the genus Arthrobacter
Authors: Zhang Gui , Yang Jing , Jin Dong , Lai Xin-He , Lu Shan , Ren Zhihong , Qin Tian , Liu Liyun , Pu Ji , Liu Yue , Ye Lin , Zhou Juan , Lv Xianglian , Tao Yuanmeihui , Xu Jianguo
Published: February 2022

Four novel bacterial strains (zg-ZUI122T/zg-ZUI10 and zg-ZUI227T/zg-ZUI100) were isolated from the intestinal contents of Marmota himalayana and characterized using a polyphasic approach. Cells were Gram-stain- and catalase-positive, urease- and oxidase-negative. Strains grew optimally at 28–30 °C, pH 7.0, with 0.5 % NaCl (w/v). A comparative analysis of 16S rRNA gene sequences revealed that strain pairs zg-ZUI122T/zg-ZUI10 and zg-ZUI227T/zg-ZUI100 belonged to the genus

Arthrobacter

and were most closely related to

Arthrobacter citreus

DSM 20133T, with similarities of 99.6 and 99.5 %, respectively. This was further confirmed by phylogenetic analyses based on the 16S rRNA gene and genome sequences. The digital DNA–DNA hybridization and average nucleotide identity values between the two new type strains (zg-ZUI122T and zg-ZUI227T) and other species in the genus

Arthrobacter

were 20.0–24.4/77.2–83.4% and 19.9–25.1/77.1–83.4%, all below the thresholds. The major cellular fatty acids detected in the two novel species included iso-C15 : 0 and anteiso-C15 : 0; the predominant polar lipids were diphosphatidylglycerol, phosphatidylglycerol and phosphatidylinositol. MK-8(H2) (77.3%) was the predominant respiratory quinone detected in strain zg-ZUI122T, while MK-8(H2) (53.7%) and MK-9(H2) (46.3%) were detected in strain zg-ZUI227T. The shared cell-wall amino acids detected in the two novel species were alanine, glutamic acid and lysine; the shared whole cell wall sugars consisted of galactose, mannose and ribose. All these analyses concluded that these four strains represent two different novel species in the genus

Arthrobacter

, for which the names Arthrobacter sunyaminii sp. nov. (zg-ZUI122T = GDMCC 1.2502T = KCTC 49677T) and Arthrobacter jiangjiafuii sp. nov. (zg-ZUI227T = GDMCC 1.2500T = KCTC 49676T) are proposed.
Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodies
Authors: Wang Yingdan , Zhang Xiang , Liu Jiangyan , Wang Yanqun , Zhan Wuqiang , Liu Mei , Zhang Meng , Wang Qimin , Liu Qianying , Zhu Tongyu , Wen Yumei , Chen Zhenguo , Zhao Jincun , Wu Fan , Sun Lei , Huang Jinghe
Published: February 2022

The highly mutated and transmissible Omicron variant has provoked serious concerns over its decreased sensitivity to the current coronavirus disease 2019 (COVID-19) vaccines and evasion from most anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies (NAbs). In this study, we explored the possibility of combatting the Omicron variant by constructing bispecific antibodies based on non-Omicron NAbs. We engineered ten IgG-like bispecific antibodies with non-Omicron NAbs named GW01, 16L9, 4L12, and REGN10987 by fusing the single-chain variable fragments (scFvs) of two antibodies through a linker and then connecting them to the Fc region of IgG1. Surprisingly, eight out of ten bispecific antibodies showed high binding affinity to the Omicron receptor-binding domain (RBD) and exhibited extreme breadth and potency against pseudotyped SARS-CoV-2 variants of concern (VOCs) including Omicron, as well as authentic Omicron(+R346K) variants. Six bispecific antibodies containing the cross-NAb GW01 neutralized Omicron variant and retained their abilities to neutralize other sarbecoviruses. Bispecific antibodies inhibited Omicron infection by binding to the ACE2 binding site. A cryo-electron microscopy (cryo-EM) structure study of the representative bispecific antibody FD01 in complex with the Omicron spike (S) revealed 5 distinct trimers and one unique bi-trimer conformation. The structure and mapping analyses of 34 Omicron S variant single mutants elucidated that two scFvs of the bispecific antibody synergistically induced the RBD-down conformation into 3-RBD-up conformation, enlarged the interface area, accommodated the S371L mutation, improved the affinity between a single IgG and the Omicron RBD, and hindered ACE2 binding by forming bi-trimer conformation. Our study offers an important foundation for anti-Omicron NAb design. Engineering bispecific antibodies based on non-Omicron NAbs may provide an efficient solution to combat the Omicron variant.
In silico analysis of predicted differential MHC binding and CD8+ T-cell immune escape of SARS-CoV-2 B.1.1.529 variant mutant epitopes
Authors: Riesgo-Ferreiro Pablo , Gudimella Ranganath , Bukur Thomas , Sorn Patrick , Rösler Thomas , Schrörs Barbara , Löwer Martin
Published: February 2022

Introduction

The B.1.1.529 (Omicron) SARS-CoV-2 variant has raised global concerns due to its high number of mutations and its rapid spread. It is of major importance to understand the impact of this variant on the acquired and induced immunity. Several preliminary studies have reported the impact of antibody binding and to this date, there are few studies on Omicron’s CD8+ T-cell immune escape.

Methods

We first assessed the impact of Omicron and B.1.617.2 (Delta) variant mutations on the SARS-CoV-2 spike epitopes submitted to the Immune Epitope Database (IEDB) with positive out-come on MHC ligand or T-cell assays (n=411). From those epitopes modified by a mutation, we found the corresponding homologous epitopes in Omicron and Delta. We then ran the netMHCpan computational MHC binding prediction on the pairs of IEDB epitopes and matching homologous epitopes over top 5 MHC I alleles on some selected populations. Lastly, we applied a Fisher test to find mutations enriched for homologous epitopes with decreased predicted binding affinity.

Results

We found 31 and 78 IEDB epitopes modified by Delta and Omicron mutations, respectively. The IEDB spike protein epitopes redundantly cover the protein sequence. The WT pMHC with a strong predicted binding tend to have homologous mutated pMHC with decreased binding. A similar trend is observed in Delta over all HLA genes, while in Omicron only for HLA-B and HLA-C. Finally, we obtained one and seven mutations enriched for homologous mutated pMHC with decreased MHC binding affinity in Delta and Omicron, respectively. Three of the Omicron mutations, VYY143-145del, K417N and Y505H, are replacing an aromatic or large amino acid, which are reported to be enriched in immunogenic epitopes. K417N is common with Beta variants, while Y505H and VYY143-145del are novel Omicron mutations.

Conclusion

In summary, pMHC with Delta and Omicron mutations show decreased MHC binding affinity, which results in a trend specific to SARS-CoV-2 variants. Such epitopes may decrease overall presentation on different HLA alleles suggesting evasion from CD8+ T-cell responses in specific HLA alleles. However, our results show B.1.1.529 (Omicron) will not totally evade the immune system through a CD8+ immune escape mechanism. Yet, we identified mutations in B.1.1.529 (Omicron) introducing amino acids associated with increased immunogenicity.

Availability

All the code and results from this study are available at https://github.com/TRON-bioinformatics/omicron-analysis.
In-vivo egfp expression in the honeybee Apis mellifera induced by electroporation and viral expression vector
Authors: Leboulle Gérard , Gehne Nora , Froese Anja , Menzel Randolf
Published: February 2022

In this study we describe egfp expression induced by two techniques: in vivo electroporation and viral transduction in several cell types of the adult honeybee brain. Non-neuronal and neuronal cell types were identified and the expression persisted at least during three days. Kenyon cells, optic lobe neurons and protocerebral lobe neurons were electroporated. Astrocyte-like glia cells, fibrous lamellar glia cells and cortex glia cells were identified. Viral transduction targeted one specific type of glia cells that could not be identified. EGFP positive cells were rather variable after electroporation, and viral transduction resulted in more homogenous groups of positive cells. We propose that these techniques remain a good alternative to transgenic animals because they potentially target only somatic cells.
NicE-C efficiently reveals open chromatin–associated chromosome interactions at high resolution
Authors: Luo Zhengyu , Zhang Ran , Hu Tengfei , Zhu Yuting , Wu Yueming , Li Wenfei , Zhang Zhi , Yao Xuebiao , Liang Haiyi , Song Xiaoyuan
Published: February 2022

Enhancer–promoter communication is known to regulate spatiotemporal dynamics of gene expression. Several methods are available to capture enhancer–promoter interactions, but they either require large amounts of starting materials and are costly, or provide a relative low resolution in chromatin contact maps. Here, we present nicking enzyme-assisted open chromatin interaction capture (NicE-C), a method that leverages nicking enzyme–mediated open chromatin profiling and chromosome conformation capture to enable robust and cost-effective detection of open chromatin interactions at high resolution, especially enhancer–promoter interactions. Using TNF stimulation and mouse kidney aging as models, we applied NicE-C to reveal characteristics of dynamic enhancer–promoter interactions.
Presenting an open data management (ecosystem) model with developing innovative information flow approach in Iranian knowledge-based companies
Authors: Feyzbakhsh Omm Al-Banin , Babalhavaeji Fahimeh , Nezafati Navid , Hariri Nadjla , Nooshinfard Fatemeh
Published: February 2022

Purpose

This study aimed to present a model for open-data management for developing innovative information flow in Iranian knowledge-based companies (businesses).

Design/methodology/approach

The method was mixed (qualitative-quantitative) and data collection tools were interview and questionnaire. The qualitative part was done to identify the influential components in open data management (ecosystem) using the grounded theory method. A questionnaire was developed based on the results of the qualitative section and the theoretical foundations, and the quantitative section was conducted by analytical survey method and the model was extracted using factor analysis and the integration of the qualitative section.

Findings

Seven categories of entrepreneurial incentives, sustainable value, innovative features, challenges and barriers, actors, business model and requirements are the main categories that should be considered in open data management (ecosystem) with all categories of research have a significant relationship with open data management.

Originality/value

The study focused on open data management from an innovation paradigm perspective and its role in developing innovative information flow. The study aimed to identify the key components of the open data ecosystem, open-data value creation, and the need to use the “open data” approach to develop data-driven and knowledge-based businesses in Iran–an emerging approach largely ignored.
An analysis of public opinions regarding Internet-famous food: a 2016–2019 case study on Dianping
Authors: Song Cen , Zheng Li , Shan Xiaojun (Gene)
Published: February 2022

Purpose

Internet-famous food (also known as “online celebrity” food) is very popular in the digital age. This study aims to investigate consumer attitudes and understand consumer behavior towards Internet-famous food.

Design/methodology/approach

The authors collected 136,835 online comments regarding “Internet-famous food” from Dianping platform between 2016 and 2019 using a web scraper. A sentiment lexicon for Internet-famous food was constructed, and sentiment analysis is further conducted to understand consumer attitudes. Additionally, the authors use topic analysis and time series analysis to study consumer behavior.

Findings

Sentiment analysis showed that the number of consumers' comments decreased over time with the attitudes being overall positive, and the Internet-famous food industry has a positive prospect; time series analysis showed that the consumption of Internet-famous food was not affected by the season; topic analysis showed that consumers' comments on Internet-famous food were rich with a large variety, covering food categories, brand, quality, service, environment and price.

Originality/value

To the authors’ knowledge, limited research has focused on public opinions regarding “Internet-famous food”. This is the first study on consumer behavior towards Internet-famous food. This article provides a unique insight into the purchasing behavior and attitude of Chinese Internet-famous food consumers through text mining.
Assessing the impact of project brief clarity using project definition rating index tool and system dynamic
Authors: Vahabi Ali , Nasirzadeh Farnad , Mills Anthony
Published: February 2022

Purpose

Briefing in a project delivery context is one of the most critical factors in the project success. It defines client requirements, translates these needs into design criteria and generates a design concept. A lack of briefing clarity is one of the main causes of design changes and may lead to project cost and time overruns. This research aims to assess the brief clarity and its influence on project cost and duration.

Design/methodology/approach

This research created the PDRI-SD technique by utilising a system dynamic (SD) approach and project definition rating index (PDRI) tool to model the complex system of project briefing and associated variables. Stock and flow diagrams of the main subsystems including the briefing, the detailed design and the construction process, were developed to assess the influence of brief clarity on project cost and time. The PDRI was adopted to measure the briefing clarity and apply in the model. PDRI-SD was then tested in Australian building refurbishment projects to assess the model's effectiveness.

Findings

The simulation results indicated that a minor reduction of the lack of clarity throughout the initial briefing process could significantly mitigate unpredicted delay and cost overruns during the detailed design and the construction stage.

Originality/value

This research contributed to the existing body of knowledge by developing an effective technique to measure the impact of lack of brief clarity on project cost and time performance. PDRI-SD can also aid project clients to predict the influence of the initial defined brief on the detailed design and construction process using the historical data of similar previous projects. It provides clients with feedback, indicating whether the brief meets project requirements or whether parts of the project brief require more clarification/rectification before the project handover to the builders.
Brand bank attachment to loyalty in digital banking services: mediated by psychological engagement with service platforms and moderated by platform types
Authors: Levy Shalom
Published: February 2022

Purpose

Various digital banking platforms (website and apps) are offered to bank customers in order to create an experiential service, which is essential in retaining customers and generating brand bank loyalty. The current study aims to examine the dynamics of customer emotional experience generated during digital banking service delivery and investigate the effect of customer psychological engagement with various digital platform types on brand bank loyalty creation.

Design/methodology/approach

A conceptual framework was constructed. Data were collected from digital banking customers through a web-based survey conducted via an online Internet panel. It involved 502 participants. The study employs a path analysis method using structural equation modeling.

Findings

The empirical results suggest that there are two paths from emotional attachment to bank loyalty: a direct path and an indirect path shaped by customer psychological engagement with service platforms. Additionally, it was found that the digital platform (website vs apps) used by the customer determined the magnitude of the impact of emotional attachment to the bank on psychological engagement with service platforms.

Practical implications

This research claims that features of digital banking services are sufficient to enhance affective brand responses and maintain long-lasting relationships with customers. Using experiential services and psychologically engaging the customers, this goal can be achieved. Additionally, well designed apps can improve interaction with services and subsequently enhance loyalty.

Originality/value

This study facilitates a better understanding of the customer's emotional–psychological state during engagement with digital service delivery. Its novelty and contribution to the literature focus on the notion that the impact of emotional attachment on bank loyalty is mediated by experiential psychological engagement with the digital platform and moderated by the type of digital platform used.
Achieving operational excellence through the lens of lean and Six Sigma during the COVID-19 pandemic
Authors: Muhammad Noor , Upadhyay Arvind , Kumar Anil , Gilani Hasan
Published: February 2022

Purpose

This article shows operational excellence achieved during the coronavirus disease 2019 (COVID-19) pandemic using the Lean, Six Sigma and Sustainability practices in small medium enterprise (SME) manufacturing firms and its impact on the performance dimensions of efficiency, growth and profit for firms located in the industrial zones of Pakistan.

Design/methodology/approach

A quantitative methodology was used and data were collected from a sample of top-level managers from 28 SME manufacturing firms located in the five industrial zones in Pakistan. A total of 62 questionnaires were included in the study.

Findings

The findings show that awareness levels of Lean, Six Sigma and Sustainability are emerging, and firms are trying to implement these concepts. However, the results show that while Lean and Six Sigma enhance firms’ performance in terms of efficiency, profit and growth, sustainability has no impact on these three performance dimensions.

Research limitations/implications

The quantitative data of a sample of 28 manufacturing firms inevitably present limitations on the generalizability of this work. Future research could employ greater quantitative data to explore the topic further. Only one particular country is studied so that future research could be carried out in other countries or regions.

Practical implications

This study may have value for policymakers and other stakeholders who need to know more about how Lean, Six Sigma and Sustainability affect a firm’s performance in industrial zones in the context of a developing country.

Originality/value

This paper contributes to knowledge in the field by integrating Lean, Six Sigma and Sustainability with firms’ performance during the COVID-19 pandemic by assessing efficiency, growth and profit dimensions where otherwise no empirical research has been undertaken in the Pakistani context.
Emotions for attention in online consumer reviews: the moderated mediating role of review helpfulness
Authors: Xu DaPeng , Ye Qiang , Hong Hong , Sun Fangfang
Published: February 2022

Purpose

With the increasing importance of e-commerce to the economy and people's lives, user-generated content, such as electronic word-of-mouth (eWOM) represented by online reviews, has exploded. On one hand, it is of great significance for review consumers (readers) to identify high-quality ones from a large number of existing reviews to assist their purchase decision. On the other hand, how to use appropriate strategies to make their published reviews more concerned by others is also important to review generators (reviewers). The purpose of this study is to understand the comprehensive relationship among review characteristics, review helpfulness and receiver attention.

Design/methodology/approach

This study uses the online movie reviews obtained from the most popular review platform in China to conduct multiple empirical analyses.

Findings

The results show that the review helpfulness plays a mediating role between the emotional characteristics of online reviews and the receiver attention, and such a mediating role is more significant among reviewers with rich review expertise. The reviewer's expertise also moderates the impact of review emotions on review helpfulness.

Originality/value

This work studies eWOM receiver involvement, which can ultimately impact product sales, but seldom be investigated in eWOM domain. Therefore, this research can enrich studies on eWOM and provide valuable practical implications as well.
Using multiple leadership frames to understand how two school principals are influencing teachers' practices and achievement of Hispanic English learners
Authors: Torres Clark Jane , Chrispeels Janet H.
Published: February 2022

Purpose

This study explored principals’ leadership actions from three leadership frameworks, instructional, socio-cultural and cultural-psychological, to understand how each contributes to influencing teachers' work and learning opportunities for Hispanic English learners.

Design/methodology/approach

The research was conducted as a case study, using multiple data sources, of two principals whose Hispanic students were successfully transitioning into English fluency.

Findings

The data indicated that each leadership approach contributed to teacher expertise and engagement with students. Principals acted in culturally responsive ways, focusing on both teacher and student strengths, and promoting a growth mindset culture.

Research limitations/implications

Although the study identified principal practices that supported teachers to more effectively educate Hispanic English learners, larger scale studies are needed to demonstrate a cause/effect relationship between actions and student learning.

Practical implications

Strengths-based and growth mindset leadership beliefs and skills, if cultivated, can effectively interact with instructional and socio-cultural leadership skills to build a robust learning environment that influences positive student outcomes.

Originality/value

This case study lays the conceptual groundwork for future studies involving more extensive samplings of schools and principals.
Higher education challenges: accounting and finance academia in a research-led teaching universities
Authors: El-Tawy Nevine , Abdel-Kader Magdy
Published: February 2022

Purpose

This paper aims to explore problems facing the recruitment of accounting and finance staff in research-led universities. “University accounting and finance (A&F) departments are experiencing difficulty in attracting and retaining suitably qualified staff” (Duff and Monk, 2006, p. 194). The literature identifies a number of reasons for the shortage of A&F phenomenon (Duff and Monk, 2006; Smith and Urquhart, 2018), including, the wide salary gap between academe and industry profession, difficulty in achieving publications in highly rated journal, high workload in teaching and marking due the limited number of A&F staff.

Design/methodology/approach

The paper provides new insights for the use of the grounded theory and how the theory has been generated from the semi-structured interviews.

Findings

This study has resulted in eight main challenges emerged, and a final theory has been generated. Implications of this research on business schools are valuable in research-led universities, the A&F staff recruitment strategies and the A&F research strategies in research-led universities.

Originality/value

The novelty of this research is based on the induction of the challenges that a business school faces, as a case study for a research-intensive teaching-led UK university, in recruiting new A and F appointees and retaining existing members of staff.
A Markov regime-switching (MS) approach to modeling the effects of fiscal policies and COVID-19 pandemic on tourism destination competitiveness in Kenya
Authors: Kimunio Isaac , Maingi Shem Wambugu
Published: February 2022

Purpose

The COVID-19 pandemic has had a catastrophic impact on the tourist activity in Kenya. Global lockdown has limited travel resulting to losses in the tourism sector. This paper discusses the specific role that fiscal policy plays to improve tourism competitiveness in Kenya. Specifically, the study examines how Kenyan government can revive the tourism economy to improve its competitiveness.

Design/methodology/approach

A tourism demand model to explore relationship between fiscal policies and inbound tourism in Kenya is developed. This study uses a Markov regime-switching (MS) regression model to establish the relationships that exist between COVID-19 pandemic, fiscal policies and tourism revenue in Kenya.

Findings

The estimation results of the Markov-switching dynamic regression showed that the coefficients of international tourists arrivals, domestic bed occupancy and international bed occupancy are positive and significant with p-values of 0.000 during the pandemic period. The findings show that the transitioning periods during the fiscal policy shifts had an effect on the international arrivals. Therefore, fiscal incentives were key in influencing tourism arrivals and bednights occupancies.

Research limitations/implications

The theoretical implications show that to promote the state of high international and domestic tourist arrivals, the government should encourage more fiscal spending initiatives that encourage the increase in tourist arrivals and occupancies such as vaccinations against COVID-19 and promoting safe spaces for visitors within the destination is key towards reviving the sector. In order to curb the hysteresis effects of COVID-19 related depression and resultant impacts on GDP, there is a need to review the national fiscal policies and target fiscal policies on the cyclical effects of the COVID-19 impacts on international tourism market.

Originality/value

This research develops an economic model that builds accurate relationships between fiscal policies, pandemics and tourism destination competitiveness as a means of informing competitive tourism management strategies and governance.
Importance of the sustainability tourism marketing practices: an insight from rural community-based homestays in Malaysia
Authors: Janjua Zain ul Abedin , Krishnapillai Gengeswari , Rehman Mobashar
Published: February 2022

Purpose

This study explored the antecedent and consequent relationship between information and communication technology (ICT) competency, sustainability tourism marketing and brand equity in rural community-based homestays in Malaysia. This study also examined how the political support by local authorities benefitted this sustainable rural tourism product development.

Design/methodology/approach

Homestays operators from three states in Malaysia–Kuala Lumpur/Selangor, Pahang and Pulau Pinang–participated in the study. Self-administered questionnaires were used to collect responses and to test research hypotheses.

Findings

The study's model empirically demonstrated ICT competency, sustainability tourism marketing practices and political support by local authorities' construct which are essential explanatory variables of homestay brand equity. The model shows high levels of consistency between the theoretical design and the empirical results of its constructs, contributing as a new step in the tourism sustainability literature.

Research limitations/implications

This study enables us to explain the “triple bottom line” theory when applied in combination with ICT competency, brand equity and newly introduced construct “political support by local authorities”.

Practical implications

The study results in evidence of crucial implications for policymakers. Policymakers should enhance cost-effectiveness, policy integration (integration of economic, environmental and social goals), and transparency and accountability to achieve United Nations' and Malaysia's sustainable tourism goals.

Originality/value

This study is an early attempt to highlight the importance of sustainable tourism marketing and brand equity in rural community-based homestays in Malaysia. This study also emphasizes that the local political authorities are the most crucial rural tourism stakeholders, and they play a key role in sustainable rural tourism transformation.
Causal relationships between the price-to-rent ratio and macroeconomic factors: a UK perspective
Authors: Lo Daniel , McCord Michael , Davis Peadar T. , McCord John , Haran Martin Edward
Published: February 2022

Purpose

House price-to-rent (P-t-R) ratios are among the most widely used measures of housing market conditions. Given the theoretical and apparent bidirectional, causal relationships and imbalances between the housing market, broader economy and financial market determinants, it is important to understand the relationship between macro- and micro-economic characteristics in relation to the P-t-R ratio to enhance the understanding of housing market dynamics. This paper studies the joint dynamics and persistence of house prices and rents and examines the temporal interactions of the P-t-R ratio and economic and financial determinants.

Design/methodology/approach

The authors examine the lead–lag relationships between the P-t-R ratios and a spectrum of macroeconomic variables using cointegration and causality methods, initially at the aggregate position and also across housing types within the Northern Ireland housing market to establish whether there are subtle differences in how various housing segments react to changes in economic activity and market fundamentals.

Findings

The findings reveal price switching dynamics and some very distinct long- and short-run relationships between macroeconomic and financial indicators and the P-t-R ratios across the various housing segments. The results exhibit monetary supply, foreign exchange markets and the stock market to be important drivers of the P-t-R ratio, with P-t-R movements seemingly tied, or are in tandem, with the overall economy, particularly with the construction sector.

Practical implications

The study shows that the P-t-R ratio can be used as an early measure for establishing the effects of macroprudential policy changes and how these may manifest across housing tiers and quality, which can further act as a signal for preventing or at least mitigating future irrational price cyclicity. These insights serve to inform housing and economic policy and macroprudential policy design, principally within lending policy and the effect of regulatory interventions and further enhance the understanding of the P-t-R ratio on housing market structure and dynamics.

Originality/value

This study is the first in the housing literature that examines the causal relationships between the P-t-R ratio and macroeconomic activity at the sub-market level. It investigates whether and how money supply, inflation, foreign exchange markets, general economic productivity and other important macroeconomic factors interact with the pricing of different property types over time.
Environmental, social and governance (ESG) performance in the context of multinational business research
Authors: Linnenluecke Martina K.
Published: February 2022

Purpose

This paper aims to examine the state of research on environmental, social and governance (ESG) performance in the context of multinational business research. This paper discusses research progress as well as various issues and complexities associated with using ESG ratings in cross-country studies and for assessing the performance of multinational enterprises (MNE) and emerging market multinationals (EMNEs).

Design/methodology/approach

The paper identifies emerging literature that focuses on tracking the development and uptake of ESG ratings in the international context. It discusses three emerging research streams: Research examining the ESG-financial performance relationship in emerging markets, research tracking the ESG performance of multinationals in the various countries and regions they are operating, and frameworks for assessing ESG-related risks on a country level.

Findings

While the emerging body of work adds an important dimension to the identification and awareness of ESG issues globally, numerous unresolved issues become evident. ESG frameworks have been built to assess corporate sustainability as it relates to firms in their “home” countries (typically with a focus on developed countries), with limited applicability and transferability to emerging markets. International firm activities are often not captured in detail and not comprehensively mapped across firm subsidiaries and a firm’s corporate supply chain where ESG issues are prone to happen, and ESG scores do not comprehensively integrate views and voices from various local stakeholders that are impacted by firm activities, particularly indigenous communities.

Research limitations/implications

Research on ESG ratings in the context of multinational business research is generally sparse and fragmented, thus creating opportunities for future research to expand on existing and emerging findings.

Practical implications

The paper creates awareness of issues to consider when using ESG ratings in cross-country studies and for assessing the ESG performance of MNEs and EMNEs: ESG scores can be subject to bias and are not weighted by materiality, which can be misleading for portfolio construction and performance measurement purposes. Managers need to be aware that ESG scores are often not capturing ESG issues occurring in supply chains and ESG issues affecting local communities.

Originality/value

This study enriches the understanding of ESG in the context of multinational business research practice.
Electrothermal response optimization of nozzle structure for multi-material rapid prototyping based on fuzzy adaptive control
Authors: Xu Jinghua , Liu Kunqian , Liu Zhi , Zhang Fuqiang , Zhang Shuyou , Tan Jianrong
Published: February 2022

Purpose

Most rapid prototyping (RP) relies on energy fields to handle materials, among which electricity has been much more utilized, resulting in distinctive responsiveness of non-linear, overshoot, variable inertia, etc. The purpose of this paper is to eliminate the drawbacks of array nozzle clogging, stringing, melt sagging, particularly in multi-material RP, by focusing on the electrothermal response so as to adaptively distribute thermal more accurate, rapid and balanced.

Design/methodology/approach

This paper presents an electrothermal response optimization method of nozzle structure for multi-material RP based on fuzzy adaptive control (FAC). The structural, physical and control model are successively logically built. The fractional order electrothermal model is identified by Riemann Liouville fractional differential equation, using the bisection method to approximate the physical model via least square method to minimize residual sum of squares. The FAC is thereafter implemented by defining fuzzy proportion integration differentiation control rules and fuzzy membership functions for fuzzy inference and defuzzification.

Findings

The transient thermodynamic and structural statics, as well as flow field analysis, are conducted. The response time, mean temperature difference and thermal deformation can be found using thermal-solid coupling finite element analysis. In physical experimental research, temperature change, together with material extrusion loading, were measured. Both numerical and physical studies have revealed findings that the electrothermal responsiveness varies with the three-dimensional structure, materials and energy sources, which can be optimized by FAC.

Originality/value

The proposed FAC provides an optimization method for extrusion-based multi-material RP between the balance of thermal response and energy efficiency through fulfilling potential of the hardware configuration. The originality may be widely adopted alongside increasing requirements on high quality and high efficiency RP.