bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract C146: Racial and Ethnic Differences in the Biological Signatures of Breast Tumors and the Immune-microenvironment: The Multiethnic Cohort Study
Authors: Loo Lenora WM , Li Yuquing , White Kami K. , Aparicio Jose A. , Setiawan Veronica W. , Haiman Christopher A. , Wu Anna H. , Wilkens Lynne R. , Le Marchand Loic , Hernandez Brenda Y , Cheng Iona
Published: September 2024

This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR008) of the Conference Program/Proceedings.

Citation Format: Lenora WM Loo, Yuquing Li, Kami K. White, Jose A. Aparicio, Veronica W. Setiawan, Christopher A. Haiman, Anna H. Wu, Lynne R. Wilkens, Loic Le Marchand, Brenda Y Hernandez, Iona Cheng. Racial and Ethnic Differences in the Biological Signatures of Breast Tumors and the Immune-microenvironment: The Multiethnic Cohort Study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C146.
Abstract C161: Rare Invasive Plasmacytoid Urothelial Carcinoma Presenting as Post-Renal Acute Kidney Injury: A Case Report
Authors: Uzeda Andressa , Shastri Toral , Moalem Kamilia , Van Kirk Kendra
Published: September 2024

Purpose: Plasmacytoid urothelial carcinoma stands out as a rare and highly aggressive histological subtype within the spectrum of bladder carcinomas, constituting only 1-3% of all variants. Summary: In this case report, we present the case of a 72-year-old patient who initially presented with significant obstructive uropathy and hydronephrosis secondary to invasive plasmacytoid urothelial carcinoma. Admission labs were concerning for a hemoglobin level of 3.8, requiring 3 units of red blood cells for correction, potassium level of 8.8, for which urgent hemodialysis was given, and a lactate level of 5.4. The patient subsequently developed delayed hematuria one month later. Follow-up CT imaging revealed an alarming increase in the size of the bladder mass, underscoring the rapid progression of the malignancy. Discussion: The aggressive nature of this malignant neoplasm can be attributed to its diffuse pattern of infiltration and high risk of residual disease following radical surgery. Clinical manifestations often include abdominal pain, but lack early-onset hematuria and other urinary symptoms typically seen with other subtypes, leading to diagnostic delays and late-stage identification. Conclusion: This case report highlights the uncommon clinical presentation of plasmacytoid urothelial carcinoma (PUC), manifesting as obstructive nephropathy. The inherent aggressiveness associated with PUC poses a challenge in treatment due to the advanced stage of the malignancy at the time of diagnosis. The scarcity of guidelines for the management of PUC underscores the need for extensive future studies to bridge this gap.

Citation Format: Andressa Uzeda, Toral Shastri, Kamilia Moalem, Kendra Van Kirk. Rare Invasive Plasmacytoid Urothelial Carcinoma Presenting as Post-Renal Acute Kidney Injury: A Case Report [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C161.
Abstract C179: Train the trainer series in Southern California a call to action for cancer prevention and screening
Authors: Ashing Kimlin , D'Souza Lauren , Gascon Brenda , Morrison James , Tejada Veronica , Garden Alexis , Gomez Jose , Yeung Sophia
Published: September 2024

Background: Alarmed by low rates of cancer screening in disenfranchised communities and medical deserts in Southern California, City of Hope launched a cancer prevention and control training program to broadly disseminate cancer screening and healthy living educational resources to Health Educators who serve the most vulnerable within our Catchment areas. Methods: The project was IRB approved as exempt came internally from City of Hope. To increase cancer prevention and uptake of cancer screening, we focused on training of Community Health Workers (CHW) from Federally Qualified Health Centers (FQHC’s), community hospitals, faith-based organizations. This community co-designed training included Cancer 101 , on best practice for Breast, Cervical, Colorectal, Lung, and Prostate screening, and Clinical and Biospecimen Studies and SB 987. Complete and online redcap enrollment survey, along with 2 brief pre and post surveys per series topic. The presentations and surveys will be facilitated by COE staff. Trainees completed surveys via RedCap. Surveys will be conducted via Redcap. Results: TTT series trained 101 trainees on 8 topics. Trainees included: Asian (14.9%), Black/African-American (6.9%), Latino/Hispanic (73.3%), Pacific Islander (2.0%), White/European American (5, 5.0%), Mix (3.0%). The gender identities trained were Male (10.9%), Female (87.1%), Transgender: Female to Male (2.0%). Facilitators of screening included Someone to talk about worries/fears about cancer (73.0%), Someone to go with and help at the appointment (53.0%), Paid time off from work (63.0%), Clinical provider recommendation/encouragement (57.0%), Free/ Low cost exams (81.0%), Insurance to pay for exams (68.0%), Free transportation (64.0%), Child care services (53.0%), In-language educational materials (62.0%), Language Interpretation services (51.0%), Community education programs (66.0%), Gift Cards or Incentives (4.0%).The participants' education level was mostly college educated (64.0%), high school (33.0%), and less than high school (3.0%). The top 3 cancers affect our community the most are breast, colon, and lung. Conclusion: The conclusion is community partners are ready to be engaged and trained in cancer prevention and screening. Cancer centers, leveraging their COE, can respond to this call to action.

Citation Format: Kimlin Ashing, Lauren D'Souza, Brenda Gascon, James Morrison, Veronica Tejada, Alexis Garden, Jose Gomez, Sophia Yeung. Train the trainer series in Southern California a call to action for cancer prevention and screening [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C179.
Supplementary Table 2 from Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen
Authors: Drabison Thomas , Boeckman Mike , Yang Yan , Huang Kevin M. , de Bruijn Peter , Nepal Mahesh R. , Silvaroli Josie A. , Chowdhury Anika T. , Eisenmann Eric D. , Cheng Xiaolin , Pabla Navjotsingh , Mathijssen Ron H.J. , Baker Sharyn D. , Hu Shuiying , Sparreboom Alex , Talebi Zahra
Published: September 2024

Table S2. Table of Hits
Table S4 from Clinical Efficacy of the HIV Protease Inhibitor Indinavir in Combination with Chemotherapy for Advanced Classic Kaposi Sarcoma Treatment: A Single-Arm, Phase II Trial in the Elderly
Authors: Sgadari Cecilia , Scoppio Biancamaria , Picconi Orietta , Tripiciano Antonella , Gaiani Francesca Maria , Francavilla Vittorio , Arancio Angela , Campagna Massimo , Palladino Clelia , Moretti Sonia , Monini Paolo , Brambilla Lucia , Ensoli Barbara
Published: September 2024

Supplementary Table 4 shows the treatment-related laboratory AE by SOC, preferred terms and study phases.
Figure 1 from Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen
Authors: Drabison Thomas , Boeckman Mike , Yang Yan , Huang Kevin M. , de Bruijn Peter , Nepal Mahesh R. , Silvaroli Josie A. , Chowdhury Anika T. , Eisenmann Eric D. , Cheng Xiaolin , Pabla Navjotsingh , Mathijssen Ron H.J. , Baker Sharyn D. , Hu Shuiying , Sparreboom Alex , Talebi Zahra
Published: September 2024

Development and validation of the CCF method. A, Uptake of 0.01 μmol/L [3H]-EβG in OATP1B1-overexpressing HEK293 cells was evaluated at room temperature over 120 minutes in 96-well plates (n = 4 technical replicates, representative of n = 2 biological replicates; error bars represent SD). B, After saturation of cells at 1 hour, 100 μmol/L unlabeled EβG was spiked into wells, causing efflux of [3H]-EβG (n = 6 technical replicates across n = 2 biological replicates; error bars represent SD). C, After 1 hour of saturation with 0.01 μmol/L [3H]-EβG, 100 μmol/L positive (blue bars) and negative (gray bars) control substrates of OATP1B1 were spiked into wells and incubated for 30 minutes. Final intracellular radioactivity was measured and presented as relative to untreated control (n = 9 technical replicates across n = 3 biological replicates; error bars represent SD. ***, P < 0.001; ****, P < 0.0001; five compared with the control). D, Stimulated efflux of preloaded [3H]-EβG stimulated after the addition of 10 μmol/L TKI. Final intracellular radioactivity was measured and presented as relative to the efflux induced by an equimolar concentration of EβG, a known substrate and efflux inducer (n = 6 technical replicates across n = 2 biological replicates; error bars represent SEM). VC, vector control.
Figure S5 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Authors: Chehade Hussein , Gogoi Radhika , Adzibolosu Nicholas K. , Galoforo Sandra , Fehmi Rouba-Ali , Kheil Mira , Fox Alexandra , Kim Seongho , Rattan Ramandeep , Hou Zhanjun , Morris Robert T. , Matherly Larry H. , Mor Gil , Alvero Ayesha B.
Published: September 2024

(A) DEGs in BRCA2null vs BRCA1null 4T1 mouse breast cancer cell line reported as log fold-change (logFC); red bars are upregulated and blue bars are downregulated; (B) Perturbation analysis of Wnt signaling pathway comparing BRCA2null vs BRCA1null 4T1 mouse breast cancer cell line; red genes are predicted to be upregulated and blue genes are predicted to be downregulated.
Figure S2 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Authors: Chehade Hussein , Gogoi Radhika , Adzibolosu Nicholas K. , Galoforo Sandra , Fehmi Rouba-Ali , Kheil Mira , Fox Alexandra , Kim Seongho , Rattan Ramandeep , Hou Zhanjun , Morris Robert T. , Matherly Larry H. , Mor Gil , Alvero Ayesha B.
Published: September 2024

Chord diagrams of top 10 differentially regulated Pathways and involved DEGs in BRCA2mt vs HRwt
Figure S1 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Authors: Chehade Hussein , Gogoi Radhika , Adzibolosu Nicholas K. , Galoforo Sandra , Fehmi Rouba-Ali , Kheil Mira , Fox Alexandra , Kim Seongho , Rattan Ramandeep , Hou Zhanjun , Morris Robert T. , Matherly Larry H. , Mor Gil , Alvero Ayesha B.
Published: September 2024

Chord diagrams of top 10 differentially regulated Pathways and involved DEGs in BRCA2mt vs BRCA1mt
Supplementary Data from Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium
Authors: Lott Paul C. , Chiu Katherine , Quino Juanita Elizabeth , Vang April Pangia , Lloyd Michael W. , Srivastava Anuj , Chuang Jeffrey H. , Carvajal-Carmona Luis G.
Published: September 2024

The full list of collaborators for PDXNet Consortium and Supplementary Data and Methods
Phase Angle as an Indicator of Depression in Maintenance Hemodialysis Patients
Authors: Li Xin , Zhang Kun , Guo Qi , Ding Wei , Niu Jianying , Zhao Junli , Zhang Liming , Qi Hualin , Zhang Suhua , Yu Chen
Published: September 2024

Introduction: Depression is a common psychiatric problem in maintenance hemodialysis (MHD) patients. Recent studies have begun to explore the relationship between body composition and depression. Phase angle (PhA), a core parameter for assessing body composition, has been observed to be associated with frailty and cognitive dysfunction. The aim of this study was to investigate the association between PhA and depression in MHD patients. Methods: This multicenter, cross-sectional study included 843 MHD patients from seven dialysis centers in Shanghai, China. Depressive symptoms were evaluated using the Patient Health Questionnaire (PHQ-9), with a score of ≥10 indicating depression. PhA was measured by bioelectrical impedance analysis. Nutritional status was assessed by malnutrition inflammation score (MIS). Multivariable logistic regression models were used to investigate the association between PhA and depression. Restricted cubic spline (RCS) analysis was utilized to examine the association. Receiver operating characteristic curve was used to identify the cut-off value of PhA for depression. Results: A total of 15.2% of patients (62.8% male, median age 66 years) had depression. Median PhA level (interquartile range) of depressed patients was 4.4° (3.9–4.9°) for males and 3.9° (3.2–4.7°) for females. There was a significant decrease in the prevalence of depression with increasing quartiles of PhA levels. In multivariable logistic regression analyses, after adjusting for age, sex, education level, spKt/V, dialysis vintage, Charlson comorbidity index, hemoglobin, and serum albumin, lower PhA levels (lowest quartile group) were significantly associated with depressive symptoms (adjusted odds ratio, 2.19; 95% confidence interval, 1.07 to 4.48), compared to higher PhA levels (highest quartile group). RCS analysis showed a relatively inverse linear association between PhA and depression. The optimal cut-off value of PhA for depression was 4.9° for males and 3.5° for females. Subgroup analyses validated the findings across patient characteristics, including age, sex, diabetes, education, and malnutrition. Conclusion: Our findings indicated an inverse association between PhA and depressive symptoms in Chinese MHD patients, suggesting that PhA could serve as a valuable indicator for assessing the risk of depression in this population. Further studies are needed to explore the potential of PhA as a prognostic tool and its implications for intervention strategies.
Colonic Fishbone-Induced Perforation Involving a Penile Colorectal Carcinoma: A Case Report
Authors: Imoto Akira , Nagata Yuki , Shinohara Yoshinori , Miyazaki Hirota , Fukumoto Masanobu , Kitae Hidehiro , Asada Masateru , Noda Masashi , Okada Kaoru , Asai Akira , Higuchi Kazuhide , Nishikawa Hiroki
Published: September 2024

Introduction: Fishbone (FB) ingestion is a rare cause of gastrointestinal perforation. Herein, we report a case of FB-induced colonic perforation, in which the presence of a penile colonic carcinoma may have contributed to the development of the perforation. Case Presentation: An 83-year-old man was admitted to our hospital with severe abdominal pain during bowel movement. Computed tomography (CT) yielded a diagnosis of sigmoid colonic perforation due to FB and secondary peritonitis. Preoperative endoscopic examination suggested that the perforation was associated with a stalked colon tumor in the vicinity. After undergoing low anterior resection and sigmoid colostomy, the patient is currently doing well. Conclusion: The incidence of FB-induced colorectal-cancer-related perforation is expected to increase in the future owing to an aging society, the increase in the rates of colorectal cancer, and increase in fish consumption. This rare case suggests that preoperative examinations are important and that even relatively small polyps can contribute to gastrointestinal perforation caused by FBs. Older individuals should exercise caution during fish ingestion.
Aesthetics and Politics of Participation in Benoît
Maubrey’s Speaker Sculptures
Authors: Keylin Vadim , Maubrey Benoît
Published: September 2024

This article discusses the aesthetic and political aspects of Speaker Sculptures, an ongoing series of participatory, site-specific sound artworks by the artist Benoît Maubrey. Informed by pragmatist aesthetics and combining artwork analyses with ethnographic observations, the text focuses on the expressive affordances of the sculptures and the way participants act on them. Using a variety of communication technologies, Speaker Sculptures artworks bridge the gaps between public, private, and virtual spaces and allow the participants to perform in public spaces without being physically present in them. Drawing on Hannah Arendt’s theory of the public as the political, Nicolas Bourriaud’s relational aesthetics, and Chantal Mouffe’s antagonism theory, this article discusses the political implications of such performances.
Deep Nonnegative Matrix Factorization With Beta Divergences
Authors: Leplat Valentin , Hien Le T. K. , Onwunta Akwum , Gillis Nicolas
Published: September 2024

Deep nonnegative matrix factorization (deep NMF) has recently emerged as a valuable technique for extracting multiple layers of features across different scales. However, all existing deep NMF models and algorithms have primarily centered their evaluation on the least squares error, which may not be the most appropriate metric for assessing the quality of approximations on diverse data sets. For instance, when dealing with data types such as audio signals and documents, it is widely acknowledged that ß-divergences offer a more suitable alternative. In this article, we develop new models and algorithms for deep NMF using some ß-divergences, with a focus on the Kullback-Leibler divergence. Subsequently, we apply these techniques to the extraction of facial features, the identification of topics within document collections, and the identification of materials within hyperspectral images.
The reliquary shrine of Saint Odilia in Borgloon (1292): An iconographical reconstruction
Authors: Reyniers Jeroen
Published: September 2024

A remarkable thirteenth-century reliquary shrine of Saint Odilia kept in the Church of Saint Odulphus in Borgloon (Belgium) – notably the oldest dated example of panel paintings in the Low Countries – has been the topic of several art historical studies. These studies attempt to unravel the iconography of the painted panels, indicating how they should be interpreted, and in which order. The difficulty of this, however, lies in the fact that the reliquary shrine has been fully overpainted but also dramatically modified in the seventeenth century to fit into a smaller location. In the process, the original roof panels were modified, with sawn-off elements lost to time. The reliquary shrine, commissioned by the Order of the Holy Cross in Huy (Belgium) in 1292, depicts multiple scenes, on all sides, that illustrate the life of Saint Odilia.

Scholars have regularly drawn on published legends of Odilia from the seventeenth and eighteenth centuries, but no consensus on the source of the images has ever been reached. The current article, however, draws attention to a much earlier, fifteenth-century manuscript of the legend of Saint Odilia that is kept in the library of the University of Liège. The manuscript, written by Wolterus of Nijmegen in 1467 with references to an even older version from 1291, has rarely been associated with the reliquary shrine, but it is of vital importance for the analysis and interpretation of the paintings. In bringing this version of the legend of Saint Odilia together with recent material-technical research carried out at the Royal Institute for Cultural Heritage (KIK-IRPA) in Brussels, a new iconographic analysis and reconstruction of the reliquary shrine is presented here.

It can now be verified that each panel had to be read from left to right, with the first roof scene with the arrival of the virgins in Rome originally positioned above the murder scene in Cologne. The second scene on the roof, where Saint Ursula receives the Pope’s blessing, was placed above the excavation and translation of Odilia’s relics. Additionally, the depiction of Saint Ursula with a banner can be seen as a highly unusual example of panel painting in the Low Countries, and it probably even shows the oldest depiction of the Pope in relation to the Saint Ursula cult. Finally, this study shows how the shrine was used: each pilgrim was given the opportunity to experience the legendary life of Saint Odilia in chronological order by walking around the reliquary shrine not once, but twice.
Jansenist Education and Racine’s Intertextuality in European Context: Can an Early Modern Translation of Andromaque Help Revisit an Old Concept?
Authors: Bajer Michał
Published: September 2024

The article deals with the intertextual dimensions of Jean Racine’s tragedy Andromaque and its rendering by the seventeenth–century Polish translator Stanisław Morsztyn. The analysis is based on an old hypothesis concerning the link between Racine’s intertextual literary practice and his erudite education at the Petites écoles de Port-Royal. The translator, although he had not received Jansenist education, was able to identify correctly and develop the original strategy of quotations and allusions. The article attempts to seek the factors that helped the Polish translator render the intertextuality of Andromaque in another cultural context. Three such factors have been proposed—the tradition of neo-Latin poetry developed both in France and in Poland, the Italian Petrarchism (along with the idea of sprezzatura), perceived not as a store of topics but as a pattern of free operation with Ancient allusions. The similarity between Racine’s education and that of Morsztyn, which combined the influence of the Polish Brethren with homeschooling, could have been the third factor. The article closes with a question concerning the perspectives of cultural studies in intertextual strategies of poets connected with various religious circles of the seventeenth century.
Les Leçons de Ténèbres: Marc-Antoine Charpentier’s Holy Week in Louis xiv’s France
Authors: Asmus Michael Thomas
Published: September 2024

The Tenebrae Lessons were important components of Holy Week in baroque France. While François Couperin’s (1668–1733) settings of the Tenebrae Lessons hold a significant place in both the repertoire and scholarly literature, Marc-Antoine Charpentier’s (1643–1704) voluminous settings of the Tenebrae Lessons deserve a place alongside those by Couperin. This article first outlines the liturgy of the Tenebrae service. Second, it examines the welcoming and influences of the Italian style on the French Leçons de Ténèbres at a time when Lully’s seizure over stage music was complete. Third, it illustrates the influence of secular music-making on this important Liturgical Office. Fourth, it briefly discusses the importance of rhetoric for Charpentier and his contemporaries and rhetoric’s influence on Charpentier’s compositional style of liturgical music.
Behavioral laterality in Greater Flamingo (Phoenicopterus roseus)
Authors: Yosef Reuven , Faitzvaig Sharon , Kosicki Jakub Z.
Published: September 2024

From a behavioral adaptation perspective, lateralization in gregarious species likely evolved to maintain cohesiveness among individuals, particularly in behaviors related to social life that require higher levels of cognitive capabilities. Thus, we hypothesized that motor coordination (lateralization) would be observed at the population level rather than at the individual level. To test this hypothesis, we studied population-level laterality in a wild population of Greater Flamingos (Phoenicopterus roseus) during the winter in Eilat, Israel. In November and December 2019, we recorded 176 behaviors in 220 flamingos, observing four behaviors: ‘At rest,’ ‘Vigilant,’ ‘Scratching,’ and ‘Preening’. The laterality indices for ‘At rest’ and ‘Vigilant’ were similar to those of ambidextrous simulated populations, indicating that these behaviors were not lateralized. However, ‘Preening’ and ‘Scratching’ were significantly left-lateralized. We conclude that at the population level, the symmetry of these behaviors results from flock pressure to coordinate population-level behaviors. Furthermore, the mechanism of lateralization is characteristic not only of the local population but of the entire species sensu stricto.
Mallomonas gemina comb. et stat. nov. (Synurales, Chrysophyceae)—a new combination based on molecular studies
Authors: GUSEV EVGENIY S. , PODUNAY YULIA A. , MARTYNENKO NIKITA A. , TRAN HOAN , KUZMIN DENIS V.
Published: September 2024

Strains of Mallomonas favosa f. favosa and Mallomonas favosa f. gemina from Vietnam have been studied. Their phylogenetic position was revealed using the SSU rDNA + rbcL cpDNA dataset. The ultrastructure of the scales and bristles was studied using transmission and scanning electron microscopy. A new combination was proposed: Mallomonas gemina comb. et stat. nov. The morphological features of the species are discussed in this paper. Based on a revision of the published data, the distribution of Mallomonas gemina was clarified. Mallomonas gemina is recorded mainly in tropical and subtropical areas in Asia.
Estimation of the Uncertainty in Daytime Cirrus Cloud Radiative Forcing and Heating Rates Due to Ice Crystal Optics
Authors: Dolinar Erica K. , Campbell James R. , Marquis Jared W. , Lewis Jasper R. , Lolli Simone , Yang Ping , Welton Ellsworth J.
Published: September 2024

The uncertainties in absolute daytime top-of-the-atmosphere (TOA) net cirrus cloud radiative forcing (CRF) and radiative heating rates are estimated at five Micro-Pulse Lidar Network (MPLNET) sites spanning the tropics to high-latitudes. One year of semi-transparent cirrus cloud (optical depth < 3.0 and cloud top temperature < −37 °C) measurements are subject to spectrally-consistent optical properties for nine different ice crystal habits, thus providing a range of possible forcing values. The annual average absolute daytime TOA net CRF is positive at Barbados, Kanpur, and, Singapore (0.59–0.67, 0.61–0.65, and 1.94–2.09 W∙m−2, respectively), negative at Fairbanks (−0.67 to −0.28 W∙m−2), and can regularly become positive or negative at Goddard Space Flight Center (GSFC) (−0.06 to 0.32 W∙m−2). The TOA CRF depends on ice crystal shape; in particular, plates lead to relatively large absolute values that decreases for bullet rosettes and columns. Uncertainties in daytime cirrus cloud radiative properties are estimated as the standard deviation of all possible outcomes when considering the different particle habits individually. Annually, the average uncertainty of the absolute daytime TOA net CRF ranges from 0.50–1.80 W∙m−2. In-cloud daytime net radiative heating rates are positive, on average, at all five sites (0.25–3.84 K/day) and have an estimated uncertainty of less than 0.30 K/day. The uncertainties in cirrus radiative forcing and heating that are characterized by assumptions regarding the ice crystal optical properties must be considered in downstream applications, including satellite retrievals and numerical weather prediction.
The structural compactness of a tropical cyclone seed affects its persistence
Authors: Lu Kuan-Yu , Chavas Daniel R. , Wang Danyang
Published: September 2024

Tropical cyclones (TC) are often generated from pre-existing “seed” vortices. Seeds with higher persistence might have a higher chance to undergo TC genesis. What controls seed persistence remains unclear. This study proposes that planetary Rossby wave drag is a key factor that affects seed persistence. Using recently developed theory for the response of a vortex to the planetary vorticity gradient, a new parameter given by the ratio of the maximum wind speed (Vmax) to the Rhines speed at the radius of maximum wind (Rmax), here termed “vortex compactness” (Cv), is introduced to characterize the vortex weakening by planetary Rossby wave drag. The relationship between vortex compactness and weakening rate is tested via barotropic β-plane experiments. The vortex’s initial Cv is varied by systematically varying their initial Vmax and Rmax in idealized wind profile models. Experiments are also conducted with real-world seed vortices from reanalysis data, which possess natural compactness variability. The weakening rate depends strongly on the vortex’s initial Cv across both idealized and real-world experiments, and the initial axis-asymmetry introduces minor differences. Experiments doubling the size of seed vortices cause them to weaken more rapidly, in line with other experiment sets. The dependence of the weakening rate on initial compactness can be predicted from a simple theory, which is more robust for more compact vortices. Our results suggest that a seed’s structure strongly modulates how long it can persist in the presence of a planetary vorticity gradient. Connections to real seeds on Earth are discussed.
A Quality Improvement Initiative to Implement Focused Family Meetings in the Surgical Intensive Care Unit: Does It Matter?
Authors: Maniar Yesha , Chalasani Haarika , Messerole Kenneth , Beck Lindsay , Stright Adam , Petrone Patrizio , Islam Shahidul , Joseph D’Andrea K.
Published: September 2024

Introduction: Communication with families is essential to improve satisfaction, especially in the critical care setting. We sought to identify patients who were not recovering as expected and to improve communication with their families.

Methods: We implemented a novel algorithm, incorporating clinical and social criteria, to determine which patients could benefit from additional communication. Patients who qualified were randomized to the intervention of a structured interdisciplinary family meeting or to standard communication in the Intensive Care Unit at the discretion of the attending. Surveys were administered to both groups to determine the primary outcome of satisfaction with communication. Wilcoxon rank-sum, chi-square, or Fisher’s exact test as appropriate was used to compare baseline characteristics and survey items between groups.

Results: There was no difference between the intervention (n = 25) and non-intervention groups (n = 33) in demographic or clinical characteristics ( P-value >.05). Surveys were able to be completed for 76% of the intervention group and 51% in the non-intervention group. There was no difference in the responses to the survey between the groups ( P-value >.05), signifying that families were satisfied with communication regardless of whether they had a structured interdisciplinary family meeting.

Conclusion: Our results are contrary to the traditionally held belief that structured family meetings improve communication. A possible explanation is that implementing an algorithm to identify patients in need of additional communication predisposes providers to be more cognizant of family needs in the Surgical Intensive Care Unit. Future research should focus on qualitative research to elucidate what aspects of communication are most useful to families.
Phubbing Makes the Heart Grow Callous: Effects of Phubbing on Pro-social Behavioral Intentions, Empathy and Self-Control
Authors: Schmidt-Barad Tomer , Chernyak-Hai Lily
Published: September 2024

Previous research has shown that phubbing (phone snubbing) negatively impacts the quality of social interaction and undermines connectedness between interaction partners. Furthermore, studies indicate that feelings of connection to others are vital to fostering empathy, which in turn is an important facet of prosociality. The current investigation explores whether this effect extends to one’s inclination to act in a pro-social manner, as well as the mediating roles of empathy and self-control. Two studies, one correlational (Study 1, N = 220) and one experimental (Study 2, N = 362) show that phubbing negatively predicts empathy, which in turn negatively impacts prosociality. Self-control was a significant mediator in the correlational design, but not in the experimental design, suggesting that repeated occurrences of phubbing, but not momentary ones, are negatively associated with self-control. The findings expand upon existing literature by providing information regarding the effects of phubbing on the person engaging in phubbing, rather than the recipient, as well as provide insights into the underlying mechanism.
Sinonasal Pathologies Masquerading as Ophthalmic Disease
Authors: Badash Ido , Palmieri Daniel , Wrobel Bozena
Published: September 2024

This report presents 2 illustrative cases of sinonasal pathologies masquerading as ocular diseases: one of a 43-year-old male with a frontoethmoidal mucocele resulting from multiple prior surgeries for juvenile nasopharyngeal angiofibroma, and the other of a 72-year-old male with sinonasal diffuse large B-cell lymphoma, both presenting primarily with ocular symptoms including diplopia and visual disturbance. Through these cases, we highlight the importance of considering sinonasal pathologies in the differential diagnosis of patients presenting with ocular symptoms and discuss the diagnostic and therapeutic approaches that enabled effective disease management. Multidisciplinary collaboration involving otolaryngologists, ophthalmologists, radiologists, and oncologists was critical in achieving accurate diagnoses and successful management of these sinonasal diseases with ocular involvement.
Culture, commerce and crowdfunding: Artists’ experiences of crowdfunding and lessons from Japan
Authors: Terui Takao
Published: September 2024

Recently, cultural crowdfunding has emerged as a prominent funding mechanism, enabling the efficient collection of micro-donations from supporters. Despite its growing significance, research on cultural crowdfunding remains limited. This paper seeks to make an original contribution by examining the impacts of cultural crowdfunding in Japan, focussing on the perspectives of performing artists and representatives of cultural organisations. It underscores the importance of considering local contexts and developing a nuanced understanding of crowdfunding’s role in the cultural and creative industries. To explore artists’ attitudes and approaches towards cultural crowdfunding, this study employs Boltanski and Thévenot’s theories of justification, specifically contrasting the values of the inspired world and the market world. By analysing cultural crowdfunding in Japan, this paper aims to enhance the understanding of artists’ policies and the role of public support for culture in the post-pandemic society.
Artistic imagination and its role in moral progress. Embracing William James’ cries of the wounded
Authors: Castella-Martinez Sergi , Weber Bernadette
Published: September 2024

In recent pragmatist-leaning philosophy and ethics, the Jamesian notion of the cries of the wounded has reemerged as a method of evoking moral progress. Philosophers like Philip Kitcher have argued that a surefooted approach to the complaints of those harmed by given social moral arrangements may lead to an improvement of moral thought, practices and institutions. Yet, at the same time, it has been acknowledged that this comprises a most evident problem: many wounded stakeholders do not cry out about their sorrow, not at last because they may not be capable of doing so. In this paper, we aim at providing a more detailed account on the communicative range of social unrest, capable of overcoming the reductive vision of some possibly harmed as being silent. Some moral philosophers have highlighted the role of the arts and the humanities in the fostering of a more empathetic imagination. With the aid of continental aesthetics (T. W. Adorno and M. Beistegui), we acknowledge the value of artistic imagination as a communicative faculty extending beyond the limits of discursive reason through non-conceptual tools. Taking it into account in moral inquiry effectively expands and provides a more detailed account on the wounded that are apparently silent, as it includes a variety of forms of communication as moral standpoints and conversational apostrophes. This finally leads us to reread James’ take on the notion of the cries of the wounded, to emphasize the necessity to understand it as a fruitful stance about inclusive moral inquiry exceeding the limits of a conceptual-discursive focus.
Learn@Lunch: Developing a continuing professional development programme to raise knowledge and awareness of drinking alcohol as an occupation in later life
Authors: Maclean Fiona , Breckenridge Jenna P , Schrag Anthony , Gray Joanna , McCormack Brendan , Kantartzis Sarah
Published: September 2024

Introduction:

Occupational therapists in acute practice are increasingly likely to work routinely with people in later life who drink alcohol. Therefore, this knowledge translation study aimed to evaluate the development of a continuing professional development Learn@Lunch programme, designed to enhance awareness and understanding of occupational therapists who work in an acute hospital setting, of drinking alcohol as an occupation in later life.

Method:

Guided by the Promoting Action of Research Implementation in Health Sciences framework, the continuing professional development programme was developed, and a qualitative evaluation undertaken. This included pre- and post-focus groups with occupational therapists ( n = 8) in an acute setting, where the programme was delivered, pre- and post-programme delivery interviews with the research champion recruited from the site, and one interview with the Allied Health Professions Service Lead.

Findings:

Findings indicate the Learn@Lunch continuing professional development programme enhanced therapist knowledge and understanding of the changing patterns of drinking alcohol in later life. However, practical barriers exist impacting how participants perceived the value and delivery of the programme.

Conclusion:

Learn@Lunch was an effective continuing professional development programme and supported enhanced knowledge and awareness of drinking alcohol as an occupation in later life, leading to changes in local acute occupational therapy practice.
Depurative capacity toward medium molecules of the dialyzer Toray NV-U® Hydrolink™: A new hydrophilic membrane to perform online hemodiafiltration
Authors: Kislikova Maria , Vega Almudena , Verde Eduardo , Abad Soraya , Vaca Marco , Acosta Adriana , González Angela , Bascuñana Arturo , Mijailova Antonia , Nava Coraima , Villa Miguel , Ruiz Juan Carlos , Goicoechea Marian
Published: September 2024

Introduction:

New dialysis membranes with new properties are being developed to improve efficacy and tolerance. The hemocompatibility of a polymeric biomaterial is influenced by the layer of water at the blood membrane interface. The new dialyzer TORAY NV-U® has a membrane Hydrolink™, designed to suppress platelet adhesion and to improve the hemocompatibility. Until now, there is no experience in online hemodiafiltration (OL-HDF). The objective of the present study is to evaluate the efficacy of this new membrane in OL-HDF therapy compared to another membrane commonly used. Other objectives are to evaluate the inflammatory response, hemodynamic tolerance, and the anticoagulation regimes.

Methods:

This is a prospective pilot study performed in five anuric patients receiving OL-HDF. For 1 month patients were kept with their usual dialyzer FX1000® (FMC). Subsequently, the dialyzer was changed to TORAY NV-U® (Hydrolink®) for 1 month. In the last dialysis session of each dialyzer, blood tests were performed to evaluate inflammation and depurative capacity.

Results:

We did not find differences in medium size removal molecules and convective volume: FX1000®: 31 ± 9 l per session and Hydrolink™ 30 ± 8 l; p = 0.7); β2microglobulin reduction ratio (RR) FX1000® FMC 83 ± 3%; Hydrolink™ 79 ± 4; p = 0.14; Myoglobin RR FX1000® FMC 72 ± 7%; Hydrolink™ 76 ± 4; p = 0.28. We did not find differences in inflammation parameters: serum IL6 with FX1000® 6.0 ± 4.2 pg/mL; Hydrolink™ 7.6 ± 5.0 pg/mL; p = 0.3. During all sessions with the two dialyzers there was adequate plasmatic filling, reaching 85 % filling. All patients had “good” dialyzer status in all dialysis sessions with TORAY NV-U®, while the dialyzer status with FX1000® was “good” in 20% of the sessions, “medium” in 30%, and “dirty” in the remaining 50% dialysis sessions.

Conclusions:

The new dialyzer Hydrolink™, TORAY NV-U® is not inferior to perform OL-HDF compared to dialyzers usually used for this therapy, and could allow decrease heparin doses. Further studies with a bigger sample size and longer follow-up will answer if Hydrolink improves inflammation and assess a better hemodynamic tolerance.
The global immune-nutrition-inflammation index (GINI) as a robust prognostic factor in glioblastoma patients treated with the standard stupp protocol
Authors: Topkan Erkan , Kilic Durankus Nilufer , Senyurek Sukran , Öztürk Duriye , Besen Ali Ayberk , Mertsoylu Huseyin , Pehlivan Berrin , Selek Ugur
Published: September 2024

Background

Systemic inflammation can significantly impact gliomas’ onset, progression, and prognosis. Glioblastoma multiforme (GBM) represents the glioma subtype characterized by the most profound inflammatory and immunosuppressive states. Consequently, various blood-borne biomarkers have been scrutinized concerning their prognostic value in GBM patients.

Objective

We sought to investigate whether the recently introduced Global Immune-Nutrition-Inflammation Index (GINI) holds prognostic significance for GBM patients treated with the standard Stupp protocol.

Methods

We retrospectively analyzed the data from a cohort of newly diagnosed GBM patients receiving the standard Stupp regimen using the propensity score-matching methodology. The GINI was computed using the original formula: GINI = [(C-reactive protein × Monocytes × Platelets × Neutrophils) ÷ (Albumin × Lymphocytes)]. We employed receiver operating characteristic (ROC) curve analysis to identify the optimal cutoff values for GINI, which could help distinguish between different survival outcomes. The primary and secondary objectives were the differences in overall survival (OS) and progression-free survival (PFS) between the GINI groups.

Results

The optimal GINI cutoff value was 1350. Out of 294 eligible patients, 211 were PSM-matched: GINI<1350 ( N = 95) and GINI≥1350 ( N = 116). Comparative Kaplan-Meier estimates indicated that the GINI≥1350 patients had substantially worse median PFS (8.0 vs 16.8 months; p < .001) and OS (14.3 vs 22.9 months; p < .001) durations than their GINI<1350 counterparts.

Conclusion

High pretreatment GINI values are robustly and independently associated with inferior PFS and OS outcomes in selected GBM patients who receive standard Stupp protocol. These findings suggest that if further confirmed, the novel GINI could serve as a valuable biological marker for the prognostic stratification of GBM patients.
Ten-day vonoprazan-based versus fourteen-day proton pump inhibitor-based therapy for first-line Helicobacter pylori eradication in China: A meta-analysis of randomized controlled trials
Authors: Gao Wenwen , Wang Qian , Zhang Xiang , Wang Lu
Published: September 2024

Background: A shorter treatment duration potentially offers the advantage of reducing adverse events (AEs) and enhancing patient compliance for Helicobacter pylori eradication. However, the difference in eradication rates between short-duration vonoprazan-based regimens and fourteen-day proton pump inhibitor (PPI)-based therapy remained unknown. Objective: This meta-analysis aimed to compare the efficacy and safety of ten-day vonoprazan-based regimens with fourteen-day conventional PPI-based therapy for H. pylori eradication. Methods: We performed a comprehensive literature search up to November 28, 2023, using PubMed. A random-effects model was applied to conduct a meta-analysis to determine the pooled Odds Ratio (OR) with 95% confidence intervals (CIs). Results: This meta-analysis included four randomized controlled clinical trials with 1560 patients. The H. pylori eradication rate of ten-day vonoprazan-based regimens was comparable to that of fourteen-day PPI-based therapy (88.7% vs 82.9%, OR 1.53, 95% CI [0.85–2.75], p = .16) in ITT analysis. The incidence of AEs in ten-day vonoprazan-based therapy was also similar to the control group (11.2% vs 17.6%, OR 0.66, 95% CI [0.33–1.31], p = .24). Conclusion: Current evidence suggests that the ten-day vonoprazan-based regimen is as effective as fourteen-day PPI-based therapy in eradicating H. pylori, with comparable AEs. However, additional research is required for confirmation.
Enhancing alginate dialdehyde-gelatin (ADA-GEL) based hydrogels for biofabrication by addition of phytotherapeutics and mesoporous bioactive glass nanoparticles (MBGNs)
Authors: Bider Faina , Gunnella Chiara , Reh Jana T , Clejanu Corina-Elena , Kuth Sonja , Beltrán Ana M , Boccaccini Aldo R
Published: September 2024

This study explores the 3D printing of alginate dialdehyde-gelatin (ADA-GEL) inks incorporating phytotherapeutic agents, such as ferulic acid (FA), and silicate mesoporous bioactive glass nanoparticles (MBGNs) at two different concentrations. 3D scaffolds with bioactive properties suitable for bone tissue engineering (TE) were obtained. The degradation and swelling behaviour of films and 3D printed scaffolds indicated an accelerated trend with increasing MBGN content, while FA appeared to stabilize the samples. Determination of the degree of crosslinking validated the increased stability of hydrogels due to the addition of FA and 0.1% (w/v) MBGNs. The incorporation of MBGNs not only improved the effective moduli and conferred bioactive properties through the formation of hydroxyapatite (HAp) on the surface of ADA-GEL-based samples but also enhanced VEGF-A expression of MC3T3-E1 cells. The beneficial impact of FA and low concentrations of MBGNs in ADA-GEL-based inks for 3D (bio)printing applications was corroborated through various printing experiments, resulting in higher printing resolution, as also confirmed by rheological measurements. Cytocompatibility investigations revealed enhanced MC3T3-E1 cell activity and viability. Furthermore, the presence of mineral phases, as confirmed by an in vitro biomineralization assay, and increased ALP activity after 21 days, attributed to the addition of FA and MBGNs, were demonstrated. Considering the acquired structural and biological properties, along with efficient drug delivery capability, enhanced biological activity, and improved 3D printability, the newly developed inks exhibit promising potential for biofabrication and bone TE.
Status Spill-Over in Cryptomarket for Illegal Goods
Authors: Andrei Filippo , Veltri Giuseppe Alessandro
Published: September 2024

Information technologies have transformed many aspects of social life, including how illegal goods are exchanged. Illegal online markets are now flourishing on various channels: the surface web (all websites accessible through a standard browser), the dark web (an encrypted internet network only accessible via anonymous browsers), and encrypted messaging applications installed on smartphones. These marketplaces take many forms, including simple web shops, chat rooms, forums, social media marketplaces, and platforms. This study focuses on the largest known darknet platform to date: AlphaBay. This cryptomarket operated from December 2014 until July 2017, when an international police operation shut it down. The dataset contains 6033 vendor profiles collected in January 2017. Using three generalized additive models (GAMs), we show that seller status positively affects sales, revenue, and sales through finalized early payment. Once sellers gain status on the platforms, they make more sales without a semi-institutionalized form of payment (e.g. escrow). On the other hand, buyers relying on status metrics as cognitive shortcuts tend to choose vendors even if they do not offer payment protection tools.