bluuebunny/crossref_metadata_2025 huggingface dataset:
Sound Field Simulation and Optimization at an Underground Subway Station
Authors: Tang C.H. , Wang Y.S. , Guo H.
Published: April 2014

The noise of underground subway stations has a great influence on the passengers and workers. The finite-element based software Actran is introduced to analyze the acoustical performance of an underground subway station in this paper. A sample station named Xingzhong Road from metro line 9 in Shanghai is considered. The finite element models for analysis of sound field characteristics are established at the two common working conditions of the subway train: coming and going. The sound pressure levels (SPLs) and energy distributions are calculated and verified by field noise tests. Based on the established models, furthermore, an optimizing scheme based on the orthogonal experimental algorithm is presented and performed. The simulation results show that the proposed method is effective and useful for improving the sound environment and reducing the harm of noise to the passengers and workers at underground subway stations.
The algorithm of optimal scheduling realization of operations of the technological systems
Authors: Акамсина  , Akamsina N. , Сербулов  , Serbulov Yuriy , Лемешкин  , Lemeshkin A.
Published: April 2014

Developed models for solving tasks scheduling of technological systems. An algorithm is proposed which allows to take into account the structural features of the simulated system to synchronize obra-processing products for various technological operations.
The modified algorithm of the wavelet transform for Morlaix analysis of low-frequency signals
Authors: Лавлинский  , Lavlinskiy V. , Бибиков  , Bibikov D. , Табаков  , Tabakov Yu.
Published: April 2014

The article considers the wavelet transform Morlaix with modernization of the basic function for a detailed analysis of low-frequency signals.
Theoretical bases of modelling of projected objects of electronic component base for synthesis of virtual reality in the form of the impacts of heavy charged particles
Authors: Лавлинский  , Lavlinskiy V.
Published: April 2014

The article describes the mathematical and algorithmic foundations of 3D simulation of electronic component base CAD on the basis of synthesis of virtual reality influences of gravity and lead nuclear particles on CMOS structures.
Sectional digital-to-analog converter for designing CMOS pipelined-CGT-ADC while minimizing switched capacitors
Authors: Рембеза  , Rembeza S. , Кононов  , Kononov V.
Published: April 2014

The formulated optimal requirements sectional bezkontaktni DAC. Considered are the main technological and frequency limitations sovovych DAC with low power consumption. Suggested 4-bit binary-weighted Zogby differential DAC architecture analogue circuit.
Generalized method for design complex units, components of program-technical complexes special purpose
Authors: Уткин  , Utkin D. , Зольников  , Zolnikov Konstantin
Published: April 2014

The generalized methodology of designing complex blocks, described the stages proektirov-tion of technical systems.
The architecture of integrated information environment for the automated designing air power lines with regard to electromagnetic safety
Authors: Фёдоров  , Fedorov D.
Published: April 2014

The paper describes the architecture of an integrated information environment for ensuring automated design of air power lines with the influence of natural screens in the form of multi-level forest belts on the distribution of the electric component of the electromagnetic field. Architek tour integrated information environment

uses a database of MathLab and MathCd. Presents a picture of the architecture of integrated information environment, showing the interaction of the database program.
Organization of the software of automated design of air power lines with regard to electromagnetic safety
Authors: Фёдоров  , Fedorov D.
Published: April 2014

The paper considers the organization of the program complex intended for automation of the design air power lines with regard to electromagnetic safety. Presents a picture of the modular structure of the software, showing the scheme of interaction of the modules. Look-Rena optimizing the use of various means and methods of protection under the respective costs and expenses in thousands of rubles.
Application of the Antihomotoxic Therapy in Obstetrics, Gynecology and Neonatology
Authors: Тезиков  , Tezikov Yu. , Санталова  , Santalova G. , Липатов  , Lipatov I. , Шарыпова  , Sharypova M.
Published: April 2014

The homotoxicology and antihomotoxic therapy are a relatively new branches in medicine involving an alternative approach to allopathic treatment. A holistic approach to treating a patient on the basis of the principles of homotoxicology implements in practice the provision “not to treat a disease, treat the patient”. Unlike allopathic medicines, most antihomotoxic drugs don’t have embryotoxic, teratogenic, mutagenic and phetotoxic effects, don’t cause a drug addiction and drug dependencies due to the content of active substances of plant, animal, mineral origin. This is widely applying them in obstetric and pediatric practice. Antihomotoxic therapy has the following advantages: minimum of contra-indications and adverse reactions, regulative principle effects on the body, nosologic approach to the prescription, synergistic effect with traditional medicines, reduction polypharmacy that allow to use this therapy in all directions of medicine and create prerequisites for the study of new methods of treatment and prevention for many diseases. Antihomotoxic therapy contributes to the activation the body´s internal reserves, the regulation of various systems and promotes long-term effect of the treatment. In numerous studies to assess the effectiveness of antihomotoxic therapy in the treatment of diseases of the reproductive system, in neonatal practices noted that the best results are achieved when antihomotoxic drugs are used in the complex treatment. However, on the background of a considerable increase of the effectiveness of the sharp decrease in the frequency of side effects of allopathic medicines noted. This review presents the main provisions homotoxicologic and successfully applied methods of antihomotoxic therapy in obstetrics, gynecology and neonatology.
Assessment on the Improvement of the System of Organization of Obstetric Aid on the Reduction of Perinatal Losses
Authors: Уйба  , Uyba V. , Торубаров  , Torubarov S.
Published: April 2014

In article the estimation proposed and implemented in the framework of the Federal Russian system of measures of improvement of obstetric services in the FMBA system, a comparative analysis of the results of the proposed measures and recommendations for their further use.
Agrochemicals Effect on Mortality from Malignant Tumors of the Female Genitalia in the Women of Rural Areas of the Republic of Dagestan
Authors: Сулейманова  , Suleymanova N.
Published: April 2014

The paper presents the data on the influence of remote consequences separate, combined and cumulative impact of agrochemicals (fertilizers and pesticides) on female mortality (1997-2006) from malignant tumors of the genitalia in the rural areas of the Republic of Dagestan. The intensive use of agrochemicals before 1995 exceeded the critical load level according to data of V.I. Polchenko and co-authors (3.93 kg/ha) and the classification of World Health Organization (4,0-5,0 kg/ha) in ten times and more. As objective quantitative indicators of the intensive use of pesticides and mineral fertilizers were applied territorial load and range of index territorial load of pesticides. To assess the environmental significance separate, combined and cumulative impacts of priority anthropogenic co-factors the author carried out predominantly two-factor analysis of variance. The share of influence, correlation coefficient and the Fisher test for each factor separately, but also for its combined and cumulative actions were calculated. It is shown the existence of significant correlation mortality from genital cancer with total territorial load of mineral fertilizers. The more significant the influence of factors on mortality was identified in terms of the total impact of the assortment index territorial load of organo-phosphorus compounds and copper-containing pesticides. It allows to considering them as secondary factors of cancer risk of death for women in rural areas.
Does Short Selling Amplify Price Declines or Align Stocks with Their Fundamental Values?
Authors: Curtis Asher , Fargher Neil L.
Published: April 2014

Critics of short selling argue that short sellers amplify price declines by targeting firms with falling prices in an unwarranted manner. Contrary to this viewpoint, we find that increases in short interest for firms following a price decline are associated with measures of overpricing based on financial statement analysis. Our results extend to short-selling activity following marketwide declines. We also find evidence consistent with the profitability of short selling following price declines being driven by valuation-based positions. Overall, our findings suggest short sellers primarily undertake valuation-based strategies following price declines and have implications for regulators. Limiting short selling following price declines is likely to impede efficient price discovery.

This paper was accepted by Mary Barth, accounting.
Sibling relationships and the construction of young people’s gendered identities over time and in different spaces
Authors: Edwards Rosalind , Weller Susie
Published: April 2014

This article explores the way that the assertion, negotiation and sanctioning of masculinity and femininity, and the construction and reconstruction of gendered identities and sexuality, are part of everyday relationships between brothers and sisters, located in time and place. This stands in some contrast to the dominant ‘cause and effect’ outcome model that characterises much research on sibling relationships. We use in-depth case studies drawn from a qualitative longitudinal study of young people’s prescribed and chosen relationships to explore how continuities and changes in the markers and dynamics of gendered identities are embedded in and constructed through the ebbs and flows of sibling relationships over time and in specific locations.
Characterization of Leukocyte Formin FMNL1 Expression in Human Tissues
Authors: Gardberg Maria , Heuser Vanina D. , Iljin Kristiina , Kampf Caroline , Uhlen Mathias , Carpén Olli
Published: April 2014

Formins are cytoskeleton regulating proteins characterized by a common FH2 structural domain. As key players in the assembly of actin filaments, formins direct dynamic cytoskeletal processes that influence cell shape, movement and adhesion. The large number of formin genes, fifteen in the human, suggests distinct tasks and expression patterns for individual family members, in addition to overlapping functions. Several formins have been associated with invasive cell properties in experimental models, linking them to cancer biology. One example is FMNL1, which is considered to be a leukocyte formin and is known to be overexpressed in lymphomas. Studies on FMNL1 and many other formins have been hampered by a lack of research tools, especially antibodies suitable for staining paraffin-embedded formalin-fixed tissues. Here we characterize, using bioinformatics tools and a validated antibody, the expression pattern of FMNL1 in human tissues and study its subcellular distribution. Our results indicate that FMNL1 expression is not restricted to hematopoietic tissues and that neoexpression of FMNL1 can be seen in epithelial cancer.
Nealkogol'naya zhirovaya bolezn' pechenipri ozhirenii
Authors: Komshilova K A , Troshina E A , Butrova S A
Published: April 2014

Non-alcoholic fatty liver disease (NAFLD) is a common chronic disease, uniting clinical and pathological changes in a liver:
steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. NAFLD is associated with obesity especially of abdominal type and metabolic
syndrome, that raises cardiometabolic risk and effects morbidity, prognosis of the disease and life expectancy of patients. This article
describes the basic mechanisms of development of NAFLD, classification, prognosis of the disease, diagnosis and treatment.
Sostoyanie serdtsa po dannym ekhokardiografiiu lits s ozhireniem, manifestirovavshimv pubertatnyy period
Authors: Mitroshina E V
Published: April 2014

47 male patients were included in this study: the group of 17 adolescents with puberty-onset obesity (aged 19,7±0,37 years), the
group of 20 adults with puberty-onset obesity (aged 32,25±0,96 years), 10 gender-matched controls (aged 20,8±0,25 years). All subjects
underwent echocardiographic and lipid profile examination. Conclusion: Among adolescent males with puberty-onset obesity normal
left ventricular geometry was encountered with similar frequency in both subgroups, with and without arterial hypertension. When left
ventricular hypertrophy develops, it may be presented as either concentric or eccentric hypertrophy. In men with puberty-onset obesity
the of patients, duration of their disease and concomitant arterial hypertension aggravate left ventricular hypertrophy. In men with puberty-
onset obesity and arterial hypertension the most common pattern of impaired left ventricular geometry is concentric hypertrophy.
Regardless of the presence of arterial hypertension, men with puberty-onset obesity have a tendency to development of left ventricular
diastolic dysfunction that may be combined with both concentric and eccentric left ventricular hypertrophy.
Urovni rezistina, adiponektinai insulinorezistentnosti u patsientov s raznoystepen'yu narusheniy uglevodnogo obmena
Authors: Skudaeva E S , Pashentseva A V , Verbovoy A F
Published: April 2014

The basis of type 2 diabetes is obesity and insulin resistance. Fat tissue is hormonaly active system which produces adiponectin,
resistin and other adipokines. These substances participate in development of insulin resistance. The article presents the results of a study
conducted to examine the role of adiponectin, resistin in development of insulin resistance in patients with IGT and type 2 diabetes.
The reduction of adiponectin level and insulin resistance was found in women suffering from IGF or type 2 diabetes and in men with
only type 2 diabetes. Resistin levels were increased in the examined patients with IGT and with type 2 diabetes.
Sindrom ROHHADNET
Authors: Kareva M A , Zhurtova I B , Orlova E M , Shiryaeva L I
Published: April 2014

Rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, electrolyte disorders like a hypernatriemia,
and neural tumor (ROHHADNET) is a newly described syndrome that can cause cardioresperitory arrests and death. It mimics several
endocrine disorders or genetic obesity syndromes during early childhood and is associated with various forms of hypothalamic-pituitary
endocrine dysfunctions that have not yet been fully investigated. The article describes the clinical case of a 4-year old patient.
Klinicheskiy sluchay narusheniyavodno-elektrolitnogo obmena kak pervogosimptoma rasprostranennogo metastaticheskogoprotsessa: osobennosti diagnostiki i lecheniyapreparatom sinteticheskogo analogavazopressina (Presayneks)
Authors: Pigarova E A , Dzeranova L K , Rozhinskaya L Ya
Published: April 2014

The main manifestations of central diabetes insipidus (CDI), a disease of absolute deficiency of hypothalamic hormone vasopressin,
are severe thirst and polyuria, which severely interferes with normal life of patients. In some cases CDI may be the first sign
of wide spread metastatic process, appearing many years after successful treatment of oncological diseases.
Beremennost' i ozhirenie
Authors: Komshilova K A , Dzgoeva F Kh
Published: April 2014

Obesity is one of the most socially significant chronic diseases, that has taken the magnitude of the epidemic, with increasing
attention to obesity in pregnant women. Despite continuous improvement of surveillance system for antenatal and obstetric care, the number
of pregnant women with obesity is increasing, in this connection, this problem is of special importance. The present review covers
the basic mechanisms involved in development of obesity and hormonal disor-ders in pregnancy, the risks and complications associated
with obesity in pregnancy. As well as measures for the prevention of excess weight before and during pregnancy.
Kompleksnyy podkhod k lecheniyu ozhireniyai metabolicheskogo sindroma u muzhchin
Authors: Rozhivanov R V , Shurdumova B O , Parfenova N S , Savel'eva L V
Published: April 2014

There is abdominal obesity in men that is accompanied with high risk of concomitant disease. The different authors data about
close relation between obesity and metabolic syndrome with hypogonadism in men are performed in this article. Reduction of body
weight due to the treatment with Xenical is accompanied by improvement of metabolic syndrome symptoms.
Osobennosti metabolizma kostnoy tkanipri sindrome mnozhestvennykh endokrinnykhneoplaziy 1 tipa
Authors: Rostomyan L G , Mokrysheva N G , Tyul'pakov A N , Vorontsov A V , Kirdyankina N O , Rozhinskaya L Ya
Published: April 2014

Bone metabolism and changes in bone mineral density (BMD) are very important in patients with multiple endocrine neoplasia
(MEN) type 1 syndrome. Case report: we present a clinical case of primary hyperparathyroidism (PHPT) in a patient with a familal MEN
1 syndrome and severe PHPT debuted at a young age w. Pituitary Cushing syndrome was diagnosed in 16 years old patient. He had marked
osteoporosis due to hypercorticism and deficiency of sex hormones (-12% from the age norm). There was significant positive dynamics
in BMD (+7% by Z-score) after remission of hypercorticism by two courses of radiation treatment and effective hormone replacement therapy
of hypogonadism. PHPT with marked decrease in BMD at three sites was revealed at age of 19 years. Obvious increase in BMD was observed
during a year after effective surgical treatment and antiosteoporotic therapy. In conclusion, this clinical case demonstrates the combined
influence of various factors on bone metabolism in patients with MEN type 1 syndrome, which requires integrated approach to successful
therapy.
Korrektsiya arterial'noy gipertonii u bol'nykh sakharnym diabetom 2 tipa: fokus na zhestkost' arteriy
Authors: Vikulova Olga Konstantinovna
Published: April 2014

Elevation of the arterial stiffness is one of the important pathogenic factors associated with a high risk of cardiovascular complications and mortality rate in patients with diabetes and metabolic syndrome. Correction of the arterial stiffness has a great value for decrease of the risk of atherosclerosis progress and organ protection. Therapy with ACE inhibitor ramipril provides not only high antihypertensive effect but also significant improvement of parameters of the arterial stiffness which indicates an additional vasoprotective effect of the drug.
Funktsional'noe sostoyanie pochek u detey i podrostkov s ozhireniem
Authors: Gaysina L R , Safina A I , Valeeva Farida Vadutovna
Published: April 2014

Overweight and obesity are the most actual problems nowadays. Number of overweight patients steadily raises and duplicates every three decades. Obesity is associated with some factors of cardiovascular risk like diabetes mellitus and arterial hypertension, frequently leads to kidney disfunction. Obesity itself can result in poor renal hemodynamics, well-known risk factor of kidney disease. We studied impact of overweight and obesity in children and adolescents on renal tubular function and glomerular filtration rate.
Sindrom Von Hippel–Lindau
Authors: Ershova E V , Yukina M Yu , Troshina Ekaterina Anatolyevna , Bel'tsevich Dmitriy Germanovich , Mustafaeva E Z
Published: April 2014

Von Hippel-Lindau syndrome - a systemic disease manifesting with multiple tumor growth, inherited by autosomal-dominant type with high penetrance. Understanding the pathogenesis of the disease is important for determining the start time of screening for the presence of the tumors and adequate treatment, including metabolic disorders.
Sindrom khronicheskoy ustalosti: sovremennye predstavleniya ob etiologii
Authors: Pigarova E A , Pleshcheva A V , Dzeranova L K , Rozhinskaya L Ya
Published: April 2014

Chronic fatigue syndrome is a disease of unexplained feeling of profound fatigue lasting for more than 6 months. This fatigue is
not relieved even after prolonged rest and is exacerbated after physical or mental work. More than 3000 scientific studies had proved that
chronic fatigue syndrome is not a form of depression or hypochondria. It is a real somatic illness that results in professional, social and
individual desadaptation. This article summarizes the contemporary etiological conceptions of this condition.
Adipotsitokiny: rezistin i faktor nekroza opukholey-α u muzhchin s abdominal'nym ozhireniem
Authors: Butrova S A , Ershova E V , Il'in A V
Published: April 2014

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Gormony zhirovoy tkani i funktsional'nayaaktivnost' shchitovidnoy zhelezy
Authors: Petunina N A , Al'tshuler N E , Rakova N G , Trukhina L V
Published: April 2014

The review presents a recent data from the literature on the physiologic and pathophysiologic role of adipose tissue hormones
(adiponectin, resistin, leptin). The article details the role of adipocytokines in atherogenesis. It also presents the results of studies depicting
the relationship between subclinical hypothyroidism, lipid metabolism and insulin resistance as well as the impact of thyroid dysfunction
upon the secretion of adipocytokines.
Uroven' visfatina syvorotki krovi i ekspressiyagena visfatina (PBEF1) v podkozhnoyi vistseral'noy zhirovoy tkani u detey
Authors: Kosygina A V , Sosunov V V , Peterkova V A , Dedov I I
Published: April 2014

The aim of this study was to investigate the characteristics of visfatin - PBEF1 - gene expression in subcutaneous and visceral
adipose tissue and serum levels of visfatin in children with relation to age and anthropometric parameters. The study included
52 patients (27 boys (52%), 25 girls (48%) aged from 2,5 to 18 years (13,8 [7,4-15,1] years)), who underwent an elective surgical intervention.
PBEF1 mRNA level was measured by real-time PCR and serum level of visfatin was quantified by immunoenzyme assay.
According to our study visfatin serum concentration in children with normal body weight was 9,2 [7,4-11,6] ng/ml, whereas in the
overweight group - 9,5 [7,5-11,1] ng/ml (p=0,5). No statistically significant gender difference in serum visfatin levels was observed.
No correlation between visfatin levels and age, pubertal stages and anthropometric indices in children was found. Statistically significant
differences in the level of gene expression between subcutaneous and visceral adipose tissue were found (р=0,002) in the
total group of children surveyed and children with normal weight, while there were no depot-specific differences in overweight children.
The study did not reveal any dependence of PBEF1 expression on age and sex of children. Expression of PBEF1 in adipose
tissue decreases with puberty (PBEF1VATγ=-0,24, р=0,02; PBEF1SATγ=-0,25, р=0,02). PBEF1 expression in adipose tissue was
not correlated with the serum visfatin (R=-0,06, р=0,6).
Narusheniya menstrual'nogo tsikla u podrostkovi molodykh zhenshchin s ozhireniem
Authors: Kuznetsova I V , Mikhaelyants V M , Santa-Mariya-Fernandes D O , Gitel' E P
Published: April 2014

Obesity plays a key role in reproductive disorders. Xenical administration results in recovery of menstrual function in 78.9% and
ovulation in 26.3% of patients with obesity. Hormone therapy in patients with obesity should be accompanied with Xenical therapy, which
has a favorable impact on further body weight reduction (13.95% from baseline) and improvement (or stability) of metabolic parameters.
Dinamika indeksa massy miokarda levogozheludochka u patsientov s arterial'noygipertoniey II-III stepeni na fone terapiiKo-renitekom i Gizaarom
Authors: Kudryavtsev A A , Ryazanov A S , Eremenko N N , Kireev S A
Published: April 2014

The regress or left ventricular (LV) hypertrophy is a main end-point of antihypertensive therapy. The aim of the present study
was to compare antihypertensive effects of two fixed combination preparations of ACE inhibitor and thiazide diuretic, enalapril 20 mg/hydrochlorthiazide
12,5 mg (Co-renitec) and losartan 50 mg/hydrochlorthiazide 12,5 mg (Hyzaar) on LV mass index (LVMI), types of left
ventricular remodeling in patients with grade II-III arterial hypertension. First group was treated with Co-renitec, second group with
Hyzaar during 24-weeks period. Results showed that both preparations significantly and to the same degree decrease LVMI. Number of
patients with normal LV geometry increases with accompanying decrease in number of patients with concentric hypertrophy and concentric
remodeling. The favorable effects were more remarkable in group treated with Hyzaar.
Morbidnoe ozhirenie - vozmozhnostikonservativnoy terapii
Authors: Ershova E V , Troshina E A , Fedorova O S , Butrova S A
Published: April 2014

Medico-social significance of morbid obesity, occurring in 2-4% of the adult population in Russia, results from the severity of obesity-
associated diseases. Conservative therapy of morbid obesity is the first line treatment and is mostly a preparation for bariatric surgery, because
the overall effectiveness of conservative measures for morbid obesity does not exceed 5-10%.
Epidemiya ozhireniya: ochevidnye i veroyatnye prichiny
Authors: Romantsova T I
Published: April 2014

Obesity and obesity-related disorders, such as type 2 diabetes, has become a global epidemic. Although there is abundant
evidence that diet and exercise are key factors in the obesity epidemic, it is equally clear that a variety of environmental factors play an
important role in this process. These include such factors as gut flora, insufficient sleep, stress, social environment, maternal influences,
endocrine disrupters and others. These factors target key hormonal signaling pathways involved in adipogenesis, regulation of appetite.
They are also likely to play important roles in obesity epidemic and are therefore worthy of further study.
Potential opportunities for treatment of metabolic syndrome withalpha-lipoic acid (Berlithion®300)
Authors: Romantsova T I , Kuznetsov I S
Published: April 2014

There are a lot of experi mental data confirmed the influence of alpha-lipoi с acid on activity of AMPK enzyme, receptors PPARα/γ and uncoupling proteins that prev ent oxidative phosphorylation (UCPl). AMPK is the enzyme responsible for food intake and energy expenditure in hypothalamus as w ell as in peripheral adipose tissue. PPARγ is the key modulator of lipid ho meostasis and adipocyte differentiation. UCPl is located in the brown adipose tissue and provides termogenesis. Via regulation of mentioned biological targets alpha-lipoic acid (Berlithion®300) lowers insulinresistance, favors weight losing process and improvement of blood lipid profile.
Normogonadotropic hypogonadism in men with obesity
Authors: Savel'eva L V , Rozhivanov R V , Shurdumova B O , Fadeev V V
Published: April 2014

Objective: to evaluate the preavalence and characteristics of hypogonadism in obese man. Research and Methods: Thestudy was performed in 31 obese man (aged 33 [22;44], BMI 40 [34,4;44,0]. Measurements during the study: chemistry panel, testosteroa and LH levels, immunoreactive insulin, HOMA index calculation. Statistically significant difference w as considered as p < 0,05. Results. Hypogonadism preavalence was 80,6%. The hypogonadism prevalence and testosterone level was more depended on age and obesity but less on duration. 100 % risk of hypogonadism w as observed in heavily obese patients. There w as no increase of LH levels. In man with low testosterone lev els HOMA index w as significantly higher со mpared to healthy subjects. Conclusion: The prevalence of normogonadotropic hypogonadism in obese men is extremely high and it represents an evidence of functional disorder of hypophyseal gonadal system. Thedecrease of testosterone levels is age-coinciding, but it is more pronounced in obese nan.
The influence of parental metabolic state on development of psy-chovegetative syndrome in children
Authors: Naugol'nih Yu V , Smirnova E N , Mudrova O A
Published: April 2014

The influence of parental metabolic state on development of psychovegetative syndrome in children. The data from the present study which involved neuropsychological assessment shows significant deteriorations in immediate audio vocal, visial memory and attention in children with metabolic syndrome which have parents with type 2 diabetes mellitus
ACTH-ectopic syndrome in patient with lung carcinoid
Authors: Dzeranova L K , Mikhailova D S , Rozhinskaya LYa , Pigarova E A , Vorontsov A V , Manchenko O V , Pekareva E V , Kuznetsov N S , Bel'tsevich D G , Kim I V , Urazovsky N Yu
Published: April 2014

ACTH-ectopic hypercortisolism is one of the most соmplex variants of endocrine pathology presenting with v arious metabolic changes. Its early localization still represents a cornerstone of radical treatment of such patients. In this article w e discuss a clinical case of woman with ectopic secretion of ACTH by malignant lung carcinoid, which localization and therefore surgical treatment wаs possible only after three-year period of extensive diagnostic workup.
Rol' leptina v narushenii reproduktivnoy funktsii pri ozhirenii
Authors: Mitsich Dragan , Tsviyovich Goran , Kendereshki Aleksandra , Shumarats-Dumanovich Mir'yana , Zorich Svetlana , Peykovich Danitsa , Markovich Kristina
Published: April 2014

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Vliyanie tabakokureniya na zdorov'e i massu telacheloveka
Authors: Mel'nichenko G A , Butrova S A , Larina A A
Published: April 2014

Tobacco smoking causes a lot of human deseases and is one of the main reasons of premature death. Smoking cessation is very
important for the patient's health but difficult for them due to development of nicotine dependence. Tobacco dependence is a chronic
disease. Smoking Cessation Clinical Practice Guideline, published in 2008, emphasize the dire health consequences of tobacco dependence,
regulate the way of treating patients who want to quit smoking, recommending the use of effective treatments, including counseling
and medications. Seven first-line medications (5 nicotine and 2 non-nicotine, including Varenicline) that reliably increase long-term
smoking abstinence rates are now available. Smoking cessation is accompanied by a moderate weigh gain. And its a strong motivational
factor to continue smoking, espcially for women. Сounseling, healthy food and physical activity are recommended for such patients.
Dzheneriki pri lechenii ozhireniya
Authors: Drobizhev M Yu
Published: April 2014

There are several pseudogenerics of Meridia® and Xenical®. Lindaxa®, registered in Russia, as a generic of Meridia®, can be at
a disadvantage to a brand on cost-quality ratio.
Ksenikal v kompleksnom lechenii patsientovs izbytochnoy massoy tela i ozhireniem
Authors: Maksimov M L
Published: April 2014

This article shows a significant efficacy and safety data of original drug Xenical in complex treatment of overweight and obesity
patients. It is emphasized that this data describe properties of original Xenical, but not generics. The generic drug Orsoten has completely
different physicochemical characteristics comparing to Xenical, this differences may lead to increase in allergic reactions and increase of
frequency and intensity of side effects.
Effekty dlitel'nogo primeneniya estrogen-gestagennoy terapii u zhenshchin reproduktivnogovozrasta s izolirovannym gipogonadotropnymgipogonadizmom
Authors: Ilovayskaya I A , Zektser V Yu , Il'in A V , Goncharov N P , Dedov I I
Published: April 2014

We examined 56 normoprolactinemic women of reproductive age (18-45 y.o.) with isolated hypogonadotropic hypogonadism
(group 1) initially and on treatment with 2 mg of 17beta-estradiol and 10 mg of dydrogesterone in sequenced manner (HRT), duration
of HRT was from 18 to 42 (median 36) months; 45 healthy women (20-38 y.o.) were included in control group 2. Initially hypercholesterolemia
was observed in 50% of cases in group 1 and 6.6% in group 2 (z=12,29, p=0,0005); nevertheless, the difference in lipid levels
between groups 1 and 2 was not statistically significant: total cholesterol levels 5,2 (4,3; 6,0) mmol/l and 4,63 (4,15; 5,15) mmol/l respectively
(1vs2, р=0,1); triglycerides 0,8 (0,62; 1,3) mmol/l and 0,76 (0,6; 0,85) mmol/l (1vs2, р=0,08); HDL 1,89 (1,24; 2,1) mmol/l
and 1,79 (1,44; 2,8) mmol/l (1vs2, p=0,85); LDL 2,7 (2,2; 3,2) mmol/l and 2,75 (2,3; 3,3) mmol/l (1vs2, p=0,64). In group 1 decrease
of total cholesterol and triglycerides concentrations was found on HRT: total cholesterol 4,8 (3,95; 5,1) mmol/l (before vs on treatment
p=0,041), triglycerides 0,65 (0,6; 0,9) (before vs on treatment p=0,044) respectively, changes in HDL and LDL levels were not revealed.
Initial concentrations of Ca++, P, and alkaline phosphatase (AP) were within normal range in all women. However, concentrations of
Ca++ and AP were higher in group 1 compared to group 2: Ca++ 1,13 (1,08; 1,19) mmol/l and 1,05 (1,03; 1,09) mmol/l (1vs2,
p=0,0016); AP 161,5 (141,8; 183) IU/l and 141,0 (119; 151) IU/l (1vs2, p=0,044). On HRT reduce in Ca++ and AP concentrations
was observed: Ca++ concentrations 1,05 (1,03; 1,10) mmol/l (before vs on treatment p=0,004), AP 139 (112; 143) IU/l (before vs on
treatment p=0,004). HRT was accompanied by improvement of clinical symptoms, had no influence on thyroid function, and provoked
physiological rise of prolactin levels.Thus, despite lacking the expressed biochemical disorders, isolated hypogonadotropic hypogonadism
in women of reproductive age have hidden negative impact on lipid and mineral metabolism. Long term HRT is safe and significantly
improved parameters of lipid and mineral homeostasis in this cohort of patients.
Osobennosti zhirovogo obmena pri bolezniItsenko-Kushinga
Authors: Dzeranova L K , Paramonov V M , Rozhinskaya L Ya , Pleshcheva A V , Manchenko O V , Vorontsov A V , Kolesnikova G S , Grigor'ev A Yu , Pigarova E A
Published: April 2014

The reported clinical case represents an example of characteristic traits in lipid metabolism and fat tissue deposition in hypercorticosolism.
Probable causes for fat mass expansion in glucocorticosteroid excess, its distinctive cushingoid distribution, role of
11β-HSD1 and glucocorticoid receptors and reversibility of specific abnormalities after correction of hypercortisolism are discussed in
the context of physiological and pathological aspects of glucocorticosteroid action.
Hormones of adipose tissue and their role in reproductive system dysfunction in obese women
Authors: Petunina N A , Makarov I O , Trukhina L V , Pchelintseva N A , Kuzina I A
Published: April 2014

The review presents data from the literature on the physiological and pathophysiological role of hormones of adipose tissue
(adiponectin, tumor necrosis factor, interleukin-6, leptin, resistin, plasminogen activator inhibitor-1). The article considers the contribution
of adipocytokines to the development of reproductive impairment. The results of studies on the relationship of the obesity and
dysfunction of the reproductive system in women are presented.The review provides data from the literature about drug therapy of polycystic
ovary syndrome.
Influence of gastric banding on quality of life in morbid obesity patients
Authors: Lavrik A S , Tyvonchuk A S , Lavrik O A
Published: April 2014

The aim of the study was unification of the results and specification of indications for different kinds of bariatric operations. In
our study we performed a comparative analysis of the quality of life with Moorehead-Ardelt II system and sweet eating syndrome in 45
patients after stomach banding for morbid obesity
Evaluation of effectiveness of orlistat in complexed obesity treatment in teenagers with metabolic syndrome
Authors: Mel'nichenko G A , Peterkova V A , Savel'eva L V , Zubkova N A
Published: April 2014

An open, comparative, randomized study of orlistat in the combined treatment of obesity in adolescents with metabolic syndrome
(IIIb phase) was held. Objective: to evaluate the efficacy and safety of the orlistat in adolescents 12-17 years with high risk of cardiovascular
disease and type 2 diabetes. The study included 60 adolescents with obesity and metabolic syndrome. The main group (n=30)
followed a hypocaloric diet and aerobic exercises and took orlistat 120 mg 3 times daily with meals, the control (n=30) group was only
on the non-drug therapy. During the study the anthropometric parameters, lipid, carbohydrate metabolism, blood pressure were evaluated.
All comparisons were performed as two-way, with the critical level of significance ≤ 0,05. Results: After 6 months therapy of orlistat
68% of adolescents achieved clinically meaningful weight loss, that led to the improvement of metabolic parameters. On therapy body
fat decreased by -6600.00 g [-7912.00, -2350.00] in the control group, respectively -2235.50 g [-4700, 00; 667.00] (p=0.011). Orlistat
was well tolerated by patients. Most adverse events (9 of 13 in the intervention group) were mild and can be attributed to the expected
adverse reactions. Conclusion: The study demonstrated clinically significant efficacy (compared with the control group), combined with
good safety records of its use in adolescents 12-17 years old with obesity and metabolic disorders.
Methods for guantificative assessment of insulin resistance
Authors: Mayorov A Yu , Urbanova K A , Galstyan G R , Mayorov A Yu , Urbanova K A , Galstyan G R
Published: April 2014

The article delineates the definition of concept of insulin resistance as well as the factors that determine tissue insulin sensitivity; defines the conception of «insulin resistance syndrome» (metabolic syndrome), its criteria and diseases that it accompanies. It is pointed that the golden standard for quantitative assessment of insulin action is hyperinsulinemic euglycemic clamp. Different indexes for indirect measurement of insulin resistance and possibilities of use of mathematical models for this matter are discussed.
Metabolic changers in oxygen transport in patients with diabetes mellitus type 2. Possibilities for correction
Authors: Bondarenko I Z , Shatskaya O A , Yadrikhinskaya M N , Kukharenko S S , Drozdova E N , Shestakova M V , Bondarenko I Z , Shatskaya O A , Yadrikhinskaya M N , Kukharenko S S , Drozdova E N , Shestakova M V
Published: April 2014

Diabetes mellitus type 2 (DM2) - is an independent predictor of development of heart failure (HF). Spiroergometry - is a method for studying blood gas exchange parameters, commonly used for specification of HF. The purpose: 1. To study features of gas exchange at patients with DM2 without cardiovascular diseases in comparison with healthy control. 2. To estimate efficiency of metoprolol for correction of metabolic disturbances in patients with DM2. Materials and methods: 12 patients with DM2, aged 48,4±8, without history of cardiovascular diseases and 15 control subjects, aged 43,6±8 underwent cardio-pulmonary exercise test on treadmill, according to Bruce protocol. Exercise energy, VO2 peak, MET, VE max, VCO2 production were observed. Results: Patients with DM2 had a reduced exercise duration (p
The role of hypogonadism correction in metabolic syndrome treatment in men: clinical case report
Authors: Tishova Yu A , Mskhalaya G Zh , Kalinchenko S Yu , Tishova Y A , Mskhalaya G. Z. , Kalinchenko S Y
Published: April 2014

We report the clinical case which reflects the peculiarities of metabolic syndrome (MS) development in testosterone deficient state. Testosterone deficiency (hypogonadism) is likely to be one of the MS components in men. Clinical case presented demonstrates the pivotal role of complex pathogenetic approach to MS treatment in hypogonadal men. The only combination of diet, exercises and testosterone therapy is beneficial in MS treatment in hypogonadal men.
Variable evidence on metformin efficiency as weight-reducing and antiblastomogenic agent: causes and consequences
Authors: Berstein L M
Published: April 2014

The growing interest to metformin in areas beyond the limits of diabetology serves as a stimulus for further evaluation of its effectiveness as a potential modulator of cancer morbidity and obesity epidemic. Gradually detectable differences in the intensity of these effects of the drug can be explained by an insufficient number of randomized trials, differences in the control groups (reference points), gender, age, pharmacogenetic and other factors, the study of which collectively promised to increase the likelihood of more favorable clinical effects of metformin and other antidiabetic biguanides in discussed areas.
Health behaviour of adolescents in Slovenia: major results from 2010 and trends from 2002 to 2010
Authors: Jeriček Klanšček Helena , Koprivnikar Helena , Zorko Maja , Zupanič Tina
Published: April 2014

Introduction: Monitoring of health behaviours, especially of adolescents, is essential for the future of each nation. Over the last decades, many changes have occurred in all aspects of our lives, affecting the health and quality of life of all people, including children and adolescents.Methods: The study is based on a quantitative research method. The survey was conducted on a representative sample of Slovenian 11-, 13- and 15-year-old adolescents, using a standardised international questionnaire (HBSC study – Health Behaviour in School-Aged Children). The survey was carried out with the assistance of school counsellors in the spring of 2002, 2006 and 2010 (n = 15.080). For determining the correlation between two individual years, the chi-square test (c2) was used. The significance level was calculated using the statistical significance value of p ≤ 0.05. Through the Cochran-Armitage trend test, it was established whether a trend existed  for the selected indicators in the period between 2002 and 2010.Results: There are some favourable trends, e.g. eating breakfast (p = 0.000), tooth brushing (p = 0.000), lower proportion of individuals who rate their health as poor (p = 0.002) and experience several psychosomatic symptoms (p = 0.000), but also unfavourable trends, e.g. decrease in physical activity (p = 0.023), increase in early alcohol consumption (p = 0.000), dissatisfaction with school (p = 0.000) and bullying others (p = 0.000).Discussion and conclusion: The conclusions of the analyses can serve as a useful basis for further work and development of systemic measures to promote healthy behaviours and prevent risky and unhealthy behaviours among children and adolescents.
Komunikacija na delovnem mestu in njen vpliv na zdravje zaposlenih v javnem zdravstvenem zavodu
Authors: Štih Anita , Ferjan Marko
Published: April 2014

Uvod: Delovno okolje in medsebojni odnosi na delovnem mestu vplivajo na zdravje zaposlenih. V raziskavi smo želeli ugotoviti, kako percepcija komunikacijske in organizacijske klime ter zadovoljstvo s komuniciranjem in informiranjem pri delu vplivajo na zdravstveno stanje zaposlenih v javnem zdravstvenem zavodu. Metode: Uporabljena je bila neeksperimentalna vzročna metoda raziskovanja. Inštrument raziskave je bil strukturiran vprašalnik. Cronbachov koeficient alfa za neodvisno spremenljivko kakovost komuniciranja v organizaciji je znašal 0,830, za odvisno spremenljivko zdravstveno stanje zaposlenih pa 0,607. V raziskavo je bila vključena celotna populacija zaposlenih v javnem zdravstvenem zavodu na ravni klinike. Anketiranje je potekalo v času od 11. aprila do 7. maja 2012. Priložnostno je bilo razdeljenih 455 vprašalnikov, realizacija vzorca je bila 32,1 % (n = 142). Za testiranje hipoteze je bila uporabljena linearna regresijska analiza, metoda Enter.Rezultati: Regresijski model je bil sprejemljiv, statistično značilen in primeren za interpretacijo (F = 29,463, p = 0,000), delež pojasnjene variance je znašal 17,1 %. Rezultati kažejo neposreden in statistično pomemben vpliv kakovosti komuniciranja v organizaciji na zdravstveno stanje zaposlenih (β = -0,421, p = 0,000).Diskusija in zaključek: Dokazali smo, da komunikacija na delovnem mestu pomembno in statistično značilno vpliva na zdravje zaposlenih v zdravstvenem zavodu. Ta podatek prispeva k razvoju nadaljnjih raziskav na področju komunikacije zaposlenih na delovnem mestu v zdravstvu ter na področju vpliva komunikacije na zdravje zaposlenih.
Competently Ordinary: New Middle Class Consumers in the Emerging Markets
Authors: Kravets Olga , Sandikci Ozlem
Published: April 2014

Although the new middle classes in emerging markets are a matter of significant interest for marketing scholars and managers, there has been little systematic research on their values and preoccupations. This article focuses on new middle class consumers to identify the new, shared socio-ideological sensibilities informed by the recent neoliberal reforms in emerging markets and examines how these sensibilities are actualized in consumption. Through an ethnographic study of fashion consumption in Turkey, the authors explicate three salient new middle class sensibilities, which implicate the mastery of the ordinary in pursuit of connections with people, institutions, and contexts. These sensibilities crystallize into a particular mode of consumption—“formulaic creativity”—which addresses consumers’ desire to align with the middle and helps them reconcile the disjuncture between the promises of neoliberalism and the realities of living in unstable societies. The article provides recommendations on product portfolio management, positioning strategies, and marketing mix adaptation decisions.
Zwischen Community Building und Open Access – Disziplinäre Forschungsinformationssysteme im Serviceportfolio Virtueller Fachbibliotheken
Authors: Mathieu Christian
Published: April 2014

Die zunehmende Projektförmigkeit von Forschung hat – in Verbindung mit den technischen Möglichkeiten des Social Web – dem Wettbewerb um akademische Visibilität und Vernetzung innerhalb der Wissenschaftsgemeinde eine neue Qualität gegeben. Zugleich eröffnet der Strukturwandel des Wissenschaftsprozesses unter den Leitbildern von Partizipation und Kooperation für Virtuelle Fachbibliotheken die Chance, sich stärker als Informationsforum ihrer jeweiligen Disziplin zu etablieren. Zu diesem Zweck möchte der folgende Beitrag für die Erweiterung von Fachrepositorien um Funktionalitäten von Forschungsinformationssystemen werben.
„Das Unterschiedliche gemeinsam bedienen“ – Zukunftsstrategien für regionale Sondersammelgebiete am Beispiel der vifanord
Authors: Sindt Ruth , Bollin Stefanie
Published: April 2014

Der Aufsatz stellt das Kooperationsmodell der vifanord vor, in der vier regional benachbarte Sondersammelgebiete die unterschiedlichen Bedürfnisse ihrer jeweiligen Fachcommunity in einem Portal gemeinsam bedienen. Innerhalb der vifanord hat sich insbesondere die Metasuche zu einem von den Wissenschaftlern geschätzten Angebot entwickelt, für welches es kein adäquates kommerzielles Produkt gibt. So plädieren die Autorinnen dafür, die vifanord mit ihrer Metasuche als Mehrwert für Regionalstudien im Rahmen der entstehenden Fachinformationsdienste auszubauen und dabei Synergieeffekte aus der Kooperation mit anderen Virtuellen Fachbibliotheken auszunutzen.
„Zwerge mit den Schultern von Riesen – Akademisches Fehlverhalten als Teil des Wissenschaftssystems?“
Authors: Schuh Dominik
Published: April 2014

Mitte Juli 2013 wurde an der Johannes Gutenberg-Universität Mainz zum zweiten Mal mit Expertinnen und Experten aus Deutschland und der Schweiz über die Problematik akademischen Fehlverhaltens beraten. Im Fokus der Betrachtung standen diesmal Ursachen und Bedingungen von Verstößen gegen die gute wissenschaftliche Praxis. Im Anschluss an die Tagung bekamen Mitarbeiterinnen und Mitarbeiter der Universität Gelegenheit, sich im Rahmen von Workshops mit Präventions- und Kontrollmöglichkeiten auseinander zu setzen.
„Big Data“ in Bibliotheken: Skalierbare Langzeitarchivierung im SCAPE Projekt
Authors: Schlarb Sven
Published: April 2014

Dieser Artikel gibt einen Überblick über das Europäische Forschungsprojekt SCAPE. Das Thema „Big Data“ wird im Kontext der digitalen Bibliothek mit einem Fokus auf Langzeitarchivierung präsentiert. Der Artikel beschreibt die Erfahrungen, die beim Aufbau einer Hard- und Software-Infrastruktur für die Verarbeitung großer Datenmengen an der Österreichischen Nationalbibliothek am Beispiel des Web-Archivs und des Austrian Books Online-Projekts gesammelt wurden.