bluuebunny/crossref_metadata_2025 huggingface dataset:
Funcionamiento y gobernanza del Sistema Nacional de Salud del Ecuador
Authors: Molina Guzmán Adriano
Published: January 2019

El Sistema Nacional de Salud del Ecuador (SNS) se ha caracterizado por su segmentación y fragmentación, lo que condiciona la implementación de políticas públicas en el sector y la provisión del servicio. Utilizando el marco analítico de la gobernanza en salud y los tipos de relaciones agente-principal en la provisión de servicios públicos, se realiza un estudio de caso en el que se analiza la configuración institucional en la que se desenvuelve el SNS del Ecuador y cómo ésta afecta la implementación de la política pública. Se observa que, a pesar de los mecanismos diseñados para mejorar la coordinación del sistema, la estructura institucional impide la implementación de las redes integradas de prestación de servicios.
“BASAT’IN TEPEGÖZ’Ü ÖLDÜRDÜĞÜ” HİKÂYEYİ PSİKANALİTİK YAKLAŞIMLA OKUMA
Authors: Topcu Mümin
Published: January 2019

Dede korkut hikâyeleri üzerinde dil,
edebiyat, siyaset ve benzeri konulu birçok çalışma yapılmıştır. Bu metinlerle
ilgile çalışmaların genellikle dil ve yapı merkezli olduğu görülür. Geçmişte,
sözlü ve yazılı gelenekte sıklıkla yer alması nedeniyle bu hikâyelerin toplumu
eğitici ve bilinçlendirici anlam yüklü metinler olduğu kanaati oluşmaktadır. Bu
kanaat, bizi Basat’ın Tepegöz’ü Öldürdüğü hikâyedeki eğitici ve
bilinçlendirici fonksiyonların neler olabileceği fikri üzerinde yoğunlaştırdı.
Yaptığımız okumalar sonucu hikâyedeki önemli motiflerin derin kökenlere sahip
ve yaşamın simgelerini barındıran siyasetname özelliği gösterdiği kanaati oluştu.
Anlatıda, bu fikrin oluşmasına neden olan ve yaşam döngüsünün parametrelerini
ortaya koyan semboller dizgesini açıklamaya çalıştık. Çalışmanın, anlatının
semboller dizgesini açıklamakla, yaşamın yasalarını barındırmakta olan siyasi
ve sosyolojik bilinç simgelerinin anlaşılmasına katkı sağlayacağı
kanaatindeyiz.
Morphofunctional Peculiarities of Platelet Rich Plasma and Its Application in Ophthalmology
Authors: Fedoseeva E. V. , Chentsova E. V. , Borovkova N. V. , Alekseeva I. B. , Romanova I. Yu.
Published: January 2019

This article is dedicated to the realistic, present-day problem in treating patients with a damaged cornea. It contains a general summary of the practical experience of treatments in various spheres of medicine and in ophthalmology in particular, concerning the new developing method of restoring tissue with the aid of platelet rich plasma. This is a branch of regenerative medicine. In ophthalmology an effective method has long been sought for treating patients with a damaged cornea. It is well-known that platelet rich plasma contains a high quantity of elements which contribute to growth: thrombocyte, transformation, insulin-like, epidermal etc. And although the mechanism of the parts their role has not been sufficiently studied, the positive results of the PRP use in various fields of surgical medicine and in particular in the treatment of burns and ulcers of the tissue, speak of the key role being played in the growth factor and the process of tissue restoration. Despite the fact that this method has not been fully studied by ophthalmologists, it is of great interest to practising doctors, considering its potential value due to it being therapeutically effective and both simple and economic to produce. Our aim here is to give a short overview of the literature which contains descriptions of the morphological qualities of thrombocytes, to note and describe the characteristics of PRP and its role in the regeneration of tissue, to make special note of the history of the discovery of the growth factor in medico-biological science and to analyze the publications which give details of the PRP use.
The Personalized Approach to the Chronic Central Serous Chorioretinopathy Treatment Based on the Navigated Micropulse Laser Technology
Authors: Volodin P. L. , Doga A. V. , Ivanova E. V. , Pismenskaya V. A. , Kukharskaya Iu. I. , Khrisanfova E. S.
Published: January 2019

The Purpose— to develop the technology and to evaluate the clinical results of personalized laser treatment of patients with chronic central serous chorioretinopathy (CSC) in a micropulse mode with individual selection of energy parameters on the navigation system Navilas 577s.Patients and Methods. 19 patients (22 eyes) with CSC after micropulse laser treatment were analyzed. The initial best corrected visual acuity (BCVA) was 0.4 to 1.0. According to OCT, the height of the  detachment of the neurosensory retina varied from 83 to 259 microns. Retinal sensitivity of the central zone was from 20.2 to 29.7 dB. Before laser treatment were individually selected the optimal energy parameters for each patient. The treatment was performed on a Navilas 577s laser system. The follow-up were 1 and 3 months.Results. 1 month after treatment the positive dynamics of functional and anatomical results in all patients was observed. Mean BCVA increased in the group to 0.81 ± 0.04. The central retinal sensitivity raised on average in the group up to 25.7 ± 0.6 dB. After 3 months, mean BCVA was 0.96 ± 0.02. Mean central retinal sensitivity increased to 26.4 ± 0.57 dB. The study revealed a high correlation between visual acuity and the central retinal thickness (0.72) and medium correlation between foveal retinal sensitivity and central retinal thickness in fovea (0.60), respectively. The correlation among visual acuity, retinal sensitivity and the symptom’s duration of the disease is negative medium (-0.63) and significant (-0.72), respectively.Conclusions. The developed personalized technology of laser treatment of chronic central serous chorioretinopathy with a micropulse mode with an individual selection of energy parameters on the Navilas 577s navigation system showed high clinical efficiency and safety. It has been established that in the course of the longstanding duration of the disease irreversible changes in the chorioretinal complex structure occured, thinning of the foveal photoreceptors layer leading to a decrease in the central retinal sensitivity and visual acuity, which substantiate the necessity for early and maximally functional-saving treatment.
Modern Aspects of Hypertensive Angioretinopathy
Authors: Moshetova L. K. , Vorobyeva I. V. , Dgebuadze A.
Published: January 2019

This literature review is devoted to modern problems of hypertensive retinopathy with arterial hypertension, as well as hypertensive retinopathy in combination diseases. The latest world studies were analyzed. Particular attention is paid to the clinical disease characteristics at the present stage with the analysis of the arterio-venous ratio, optic nerve edema (with high blood pressure figures) using an automated system, vector analysis, suggesting a new arteriovenous classification, called Web Integration (Wivern). The modern pathogenesis of hypertensive retinopathy, namely the ratio of proangiogenic and anti-angiogenic factors, the role of inflammation (C-reactive protein), the role of endothelin-1, endostatin, interleukin-8 (IL-8), and the main fibroblast growth factor (bFGF ), angiogenin and uric acid. The special importance of fundus registration is reflected with the help of the newest equipment at high figures of arterial pressure in patients with hypertensive retinopathy. It is known that according to the World Health Organization (WHO), mortality rate from cardiovascular diseases is 31 %. Hypertension is the main risk factor for coronary heart disease, myocardial infarction, heart failure, stroke, kidney disease and early death. Questions of eye blood flow in hypertensive angioretinopathy in patients with arterial hypertension (AH) are covered. Hypertensive retinopathy (HR) is a retinal disease that is caused by a prolonged increase blood pressure (BP) and leads to a decrease in vision. The data of pathophysiology are analyzed (arterial hypertension (AH) leads to thickening of the vessels of the inner membrane (intima), to thickening of the medial membrane (media) — hyperplasia of the muscular tissue followed by hyaline degeneration with the development of sclerotic changes). The questions of modern diagnostics with retinal morphological status evaluation (OCT), detection of eye fundus condition with newest fundus camers, pathogenetic aspects are discussed. This review will help to prevent the development of more severe forms of hypertensive retinopathy. This information will allow us to identify the most significant indicators in the early diagnosis of hypertension angioretinopathy.
Prospectiva de futuro del proceso de enseñanza-aprendizaje del Lenguaje Musical en España
Authors: Sánchez Parra María José
Published: January 2019

Este artículo tiene por objetivo conocer cuál ha sido la evolución del proceso de enseñanza-aprendizaje del Lenguaje Musical, así como una prospectiva de su futuro como materia fundamental en los Conservatorios Profesionales de Música de España. La metodología de investigación aplicada ha sido el análisis de contenido, la entrevista semi-estructurada a expertos de prestigio en la docencia del Lenguaje Musical, los grupos de discusión y la encuesta. Los resultados obtenidos muestran la necesidad de un diseño educativo innovador para la asignatura de Lenguaje musical en los Conservatorios Profesionales de Música de España.
Primary kaposiform hemangioendothelioma of ulna
Authors: MD Sami Sam Hajialiloo , MSc Azra Izanloo , MD Masoud Mirkazemi
Published: January 2019

Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that can be potentially low malignant and mainly affects infants and adolescents. This tumor usually is seen in the skin, soft tissue, and retroperitoneum. This study is a case of KHE in the long bone of the ulna. The subject was a 7-year-old female patient with osteolytic lesion in the forearm without cutaneous lesions. Histologically, the neoplasms comprised of nodules of spindle-to oval-shaped cells that grew in an infiltrative fashion. The results of 2-year follow-up of the patient after enblec resection were desirable and no recurrence was observed. This is the first study to report a case of KHE of the bone in Iran.
Keywords: Bone, Hemangioma, Hemangioendothelioma, Kaposiform
Efecto de la calabaza fermentada (Cucúrbita pepo) en los parámetros productivos y de salud en cerdos en preceba
Authors: Medina-González Rafael , Ortiz-Milán Abel , Elias-Iglesias Arabel , Álvarez-Villar Victor M. , Brea-Maure Odelin
Published: January 2019

Se utilizaron 30 cerdos en preceba del hibrido Yorkshire x Landrace, de peso promedio 7 kg, durante 42 días, coincidiendo entre los 33 a los 76 días de edad de los cerdos, con el objetivo de sustituir el 0 (control); 15 y 30 % del pienso convencional por el fermentado de calabaza, según diseño completamente aleatorizado con tres tratamientos y diez repeticiones, cada cría se consideró como una repetición. Se determinó la concentración de levaduras en el fermentado de calabaza donde se observó una estabilidad aparente en la concentración de estos microorganismos a los 21 días de elaborado el fermentado, mientras que en los cerdos el peso vivo final (27.30; 28.00 y 27.50 kg), la ganancia media diaria (483; 502 y 488 g/día), el consumo de materia seca (30.37; 30.38 y 30.33 kg) y la conversión de la materia seca (1.50; 1.44 y 1.48 kg MS/kg PV respectivamente); no presentaron diferencia significativa entre los tratamientos evaluados, sin embargo en el tratamiento control hubo mayor cantidad de animales con diarreas y la mortalidad alcanzó el 10 %; mientras que en los tratamientos que incluyeron fermentado de calabaza el índice de diarrea fue mínimo y las muertes nula. Se concluyó que el fermentado de calabaza no afectó los indicadores productivos de los cerdos en preceba, al tiempo que reduce las ocurrencias de diarreas y evita las muertes en esta categoría tecnológica.
Analysis Quality of Water River and Quality of Well Water in The Surrounding of Rejo Agung Baru Sugar Factory Madiun
Authors: Ningrum Susanti Oktavia
Published: January 2019

The quality of wastewater sugar factory produced will affect the environmental health quality around the factory. The study aimed to analyze the quality of water river and the quality of wells around the Rejo Agung Baru sugar factory in the Madiun. This study is an descriptive observational. The samples comprised of 5 sampels of water rivers and 7 samples of well water. The results of the study at the quality of water river showed that there are parameters (BOD5 and temperature) unqualified with the quality standards based on the East Java Regional Regulation No. 2 of 2008 about Water Quality Management and Water Pollution Control in the East Java, the quality of water river is also affected by the waste water, trash, agricultural waste, and other pollutants. The result of measuring the quality of water well showed that there are parameters (organic substance) unqualified with quality standards based on Permenkes No: 416/Menkes/PER/ IX/1990 about the Terms and Water Quality Monitoring, the quality of Well water is also affected by the quality of water river, a distance of toilet, domestic wastewater and other pollutants. The quality of water river and the quality of well water have decreased that required supervision on the quality of a river water and the quality of water of a well.
Blood Lead Levels and Healthy Complaint in Printing Workers of Unipress Surabaya
Authors: Humairo Mika Vernicia , Keman Soedjajadi
Published: January 2019

Lead is found in the printing ink, it gets into the human body through skin absorption and ingestion. Blood lead level > 10 μg/dL causes health disturbances. The purpose of this study was analyzed blood lead level and healthy complaints in printing worker of Unipress Surabaya. This research was observational analytic with cross sectional approach. The subject was printing production process employees and administration employees. Population of production process employees were 10 people and administration employees were 7 people. Whereas, sample of production process employees were 9 and administration employees were 6. The determination of the sampling used simple random sampling. Data analyzed with chi-square test and t-independent test. Blood lead level of production process employees have  ± SD = 6.16 ± 0.37 μg/dl, whereas the blood lead level of administration employees have ± SD = 6.0±0.18 μg/dl. Based on the results by t-independent test (p = 0.371) which indicated there was no difference blood lead level of production process employees and administration employees. Based on the test results by chi-square (p = 0.005) which indicated there was difference in central nervous system disturbances of study group and control group. It is concluded that blood lead level in printing worker of Unipress Surabaya are normal. Though it can suggested to use gloves while working, increase hygiene and sanitation behavior, reducing smoking habit, as well as routine health check up to see the blood lead leve
Islamic Banks’ Financial Stability and Its Determinants: a Comparison Study With Conventional Banks in Indonesia
Authors: Pambuko Zulfikar Bagus , Ichsan Nur , Anto MB. Hendrie
Published: January 2019

The research aimed to analyze the stability of Islamic banking industry and its determinants in Indonesia. The same analysis was also done to the conventional banking industry as Indonesia practices dual banking systems. Using monthly data on Indonesian Banking Statistics for 2008-2013, this research implemented the Banking Stability Index (BSI) model for predicting the bank's stability. The analysis began with measuring BSI then using VECM to examine the effect of variables on BSI. The result showed that the BSI of both banking system was exhibiting the moderate level of stability though Islamic banking is more stable and safe way of financing than conventional banking. The shocks of inflation, exchange rate, efficiency, income diversity, liquidity, and Industrial Production Index responded positively by Islamic Bank' stability, while interest rate and market share responded negatively. In another hand, conventional bank' stability responded positively the shock of the exchange rate, income diversity, interest rate, liquidity, and market share, while other variables responded negatively. The results of shocking variables strongly indicated that the conventional banking is more vulnerable than Islamic banking. Islamic banking looked tend to the shock resistance and less volatile. This conclusion, however, might be still questioned as the BSI was not designed specifically for Islamic banking. Therefore, constructing an Islamic BSI (under Islamic banking characters) was important to measure the banking stability more appropriate and to develop a proper early warning system for Islamic banking industry.
Two-year outcome of a patient after LASIK following SMILE lenticule in situ implantation to treat a rare complication
Authors: Zhao Jing , Shang Jianmin , Niu Lingling , Xu Haipeng , Yang Dong , Zhao Yu , Fu Dan , Zhou Xingtao
Published: January 2019

Background: To report a case of femtosecond laser-assisted in situ keratomileusis (FS-LASIK) following small incision lenticule extraction (SMILE) lenticule in situ implantation to treat a rare complication.
Case presentation: The hyperopic left eye of a 46-year-old patient with refraction of +7.75 diopters sphere (DS)/-1.25 diopters cylinder (DC)×5°and corrected distance visual acuity (CDVA) of 20/50 mistakenly underwent SMILE procedure for myopic astigmatism (-8.50DS/-1.50DC×175°) due to medical record error. The extracted lenticule was subsequently re-implanted in situ. After 8 months, the left eye underwent FS-LASIK to correct hyperopia and astigmatism （+5.0DS/-0.75DC×100°. Two years after FS-LASIK, corneal tomography showed no ectasia and microscopy revealed transparent cornea. The left eye obtained CDVA of 20/50 and the refraction was -0.75DS/-0.25DC×165°.
Conclusion: SMILE lenticule in situ implantation offers a solution for rare complications and correction of refractive error following lenticule re-implantation with FS-LASIK is feasible and effective.
Keywords: SMILE, Lenticule, Re-implantation, Complication
Newcastle disease virus - effective alliance in the fight against cancer
Authors: Sitkovskaya A. O. , Zlatnik E. Yu. , Novikova I. A. , Kit O. I.
Published: January 2019

Cancer is still the leading cause of death in developed countries. Oncolytic virus (OV) therapy is a promising new strategy for tumor growth inhibition. Despite the fact that the oncolytic function of some viruses was discovered in the last century, it has not been properly applied and recognized. The viruses of the Paramyxoviridae family, particularly Newcastle disease virus (NDV), are powerful oncolytic and immunostimulating agents non-pathogenic in humans. NDV is characterized by a selective infection and spread of the virus in tumor cells, direct cytopathic effect, and indirect induction of the innate and adaptive immune system of the host. However, intratumoral administration of OVs is not always possible and results in only local effect. There is an assumption that immune system cells can be used as possible carriers of OVs to provide temporary protection against immune system factors of the body. Dendritic cells (DCs) were the most effective cellular carriers among numerous types of immune cells evaluated in studies of the OV effect. In conclusion, the authors suggest that the use of OVs as an adjuvant for tumor antigens in the development and improvement of DC vaccine optimizes the development of antitumor immune response, STAT - signal transducer and activator of transcription.
Protein carbonylation as a possible way to modulate breast cancer cell proliferation
Authors: Shakhristova E. V. , Stepovaya E. A. , Sadykova A. A. , Novitsky V. V.
Published: January 2019

Introduction.High rates of cancer incidence and mortality worldwide dictate the necessity of developing new methodological approaches in understanding the molecular mechanisms of cancer progression associated with intracellular redox regulation imbalance.

The objectiveof the study was to evaluate the role of protein carbonylation in regulating breast cancer cell proliferation under redox status modulation.

Materials and Methods. In the intact breast cancer cells and in the cells cultured under redox status modulation using 5mM N-ethylmaleimide (an - SH group blocker) and 5 Mm 1,4-dithioerythritol (a thiol group protector), the concentration of thioredoxin and its carbonylated form was measured using Western blot analysis. The activity of thioredoxin reductase and the level of protein carbonyl derivatives were determined using spectrophotometry. Cell cycle phase distribution was evaluated by flow cytometry.

Results and Discussion. Under the effect of N-ethylmaleimide, cell cycle arrest in the S-phase was confirmed by oxidative modification of proteins, including thioredoxin carbonylation. When culturing MCF-7 cells in the presence of 1,4-dithioerythritol, cell cycle arrest in the G0/G1 phases was associated with a rise in the concentrations of reduced thioredoxin and glutathione forms.

Conclusion.The thioredoxin system and oxidative modification of proteins are involved in redox-dependent modulation of breast cancer cell proliferation. Studies in the area of redox proteomics offer great potential to seek molecular targets of malignant transformation of breast cells.
The level of sialic acids and imidazole compounds in the saliva of patients with lung cancer of different histological types
Authors: Belskaya L. V. , Kosenok V. K.
Published: January 2019

In recent years, the possibility of using known and new tumor markers in primary and differential diagnosis of lung cancer has been actively studied.

The purpose of the studywas to study the level of sialic acids, the total content of imidazole compounds and seromucoids in the saliva of patients with lung cancer, depending on the histological type of tumor.

Material and Methods. Total of 478 people took part in in the case-control study. They were divided into 3 groups: the main group (lung cancer, n=218), the comparison group (nonmalignant lung pathologies, n=60) and the control group (conditionally healthy, n=200).

Results.Patients with non-malignant lung pathologies exhibited increased levels of imidazole compounds and seromucoids and decreased levels of sialic acids. A statistically significant decrease in the level of sialic acids was observed in patients with non-small cell lung cancer. The concentration of imidazole compounds was significantly higher in all study groups, except for carcinoid tumors. The nature of the changes in the studied parameters were ambiguous and depended on both the histological type of the tumor and the stage of the disease, including the presence / absence of distant and regional metastasis.
COMPUTER VISION SYSTEM FOR COLOR MEASUREMENTS OF MEAT AND MEAT PRODUCTS: A REVIEW
Authors: Tomasevic Igor B.
Published: January 2019

Meat and meat products color evaluation ability of a computer vision system (CVS) is investigated by a comparison study with color measurements from a traditional colorimeter. A statistical analysis revealed significant differences between the instrumental values in all three dimensions (L*, a*, b*) between the CVS and colorimeter. The CVS-generated colors were more similar to the sample of the meat products visualized on the monitor, compared to colorimeter-generated colors in all (100 %) individual trials performed. The use of CVS should be considered a superior alternative to the traditional method for measuring color of meat and meat products.
The life path of professor Max Wilms (1867 – 1918)
Authors: Morgoshiya T. Sh. , Syroezhin N. A.
Published: January 2019

The scientific activity of M. Wilms is characterized by a versatility of his surveys and breadth of research. M. Wilms contributed to the development of clinical surgery and oncology by proposing new methods for diagnosing and treating the main forms of malignant tumors of the genital organs and kidneys; he made a significant contribution to the practice of world medicine. M. Wilms conducted classical studies of  teratoid tumors of  the ovaries and testes, mixed tumors, kidney tumors. The  tumor described by M. Wilms in 1899, is one of the most frequent malignant neoplasms in children, it usually occurs from 2 to 5 years, but it can be detected at any age, even in very old people. A talented scientist and teacher demanding of himself and his students, Max Wilms published over 130 scientific works, he was the only author of the vast majority of them.

Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Speech disorders in young and preschool children
Authors: Yagunova K. V. , Gaynetdinova D. D.
Published: January 2019

With every coming year more and more children suffer from speech problems, making their parents visit various specialists (pediatrician, neurologist, speech therapist, defectologist), who use their diagnostic techniques to detect speech disorders. The absence of a unified classification system and diagnostics leads to the late correction of speech disorders. The article considers main reasons for disturbances in normal speech development, risk factors of speech pathology, clinical manifestations of some types of speech disorders, various approaches to diagnosis and systematization of speech disorders.

Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Analysis of clinical and immunological parameters in children with joint pathology
Authors: Spivakovskaya A. Yu. , Spivakvskiy Yu. M. , Chernenkov Yu. V.
Published: January 2019

For the purpose of comparative analysis of clinical and immunological parameters in children with juvenile idiopathic arthritis (n=56) and reactive arthritis (n=22) we determined the concentration of individual Th1- (IL-1β, IL-6, INF-γ), Th2- (IL-4) and Th17- associated interleukins (IL-17) in the blood serum. We conducted clinical examination of the patients, taking into account the duration of the disease, the amount of drug therapy and indicators of functional status. The concentration of interleukins in the serum was determined by enzyme immunoassay using ready-made commercial kits. We found that the course of juvenile idiopathic arthritis and reactive arthritis is characterized by a certain unidirectionality of disorders in the system of Th1-and Th2-associated cytokines. There were indentified key correlations between the studied interleukins for the diseases concerned. We proposed an interrelated analysis of immunological activity indicators, which allowed simplifying the differential diagnostics of articular form of juvenile idiopathic arthritis and reactive arthritis.

Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
TÜRK DÜNYASI HAYVAN MASALLARINDA TESPİT EDİLEN DEĞERLER
Authors: DAĞI Fahri , ALPTEKİN Mehmet , KAPLAN Tuba
Published: January 2019

Masallar, insanın yaşadığı dünyada ufkunu ve hayal dünyasını zenginleştiren, yaratıcı bir birey olmasına yardımcı olan, çocuğun doğumuyla tanıştığı bir edebi türdür. Masallar yoluyla birey farklı dünyaların kapılarını aralar ve yeni şeyler öğrenip keşfetmeye başlar. Bir varmış bir yokmuş ile aralanan masal dünyası bireyin bazı temel değerleri kazanmasında önemli bir role sahiptir. Çocuklar tarafından sevilen, çocuğun merak ve keşfetme güdüsünü harekete geçiren masallar; çocukta empati kurmayı, yaşadığı dünyayı tanımayı, ele aldığı konularla çocuklara temel değerlerin aşılanmasında önemli bir araçtır.Bu çalışmanın amacı, Türk dünyasından tespit edilen hayvan masallarında yer alan değerleri tespit etmektir. Nitel araştırma yönteminin benimsendiği bu çalışmada veri toplama amacıyla doküman analizi tekniğinden faydalanılmıştır. Araştırmada, Ali Berat Alptekin’in "Hayvan Masalları" ve Nedim Bakırcı'nın "Türk Dünyası Coğrafyasında Tespit Edilmiş Hayvan Masalları Üzerinde Bir İnceleme", adlı eserleri başta olmak üzere Türk dünyasının farklı coğrafyalarında tespit edilmiş hayvan masallarında yer alan değerler Schwartz Değerler Ölçeği’ne göre sınıflandırılmış ve kullanım sıklığını tespit edilmiştir. Araştırma sonucunda bahsi geçen masallarda güç, güvenlik, evrensellik, başarı, geleneksellik, yardımseverlik, uyma, uyarılma, özyönelim ve hazcılık değerine yer verildiği tespit edilmiştir. Yardımseverlik değerinin yoğun bir şekilde işlendiği saptanmıştır. Geçmişle bağ kurulmasını ve geleceğe değerlerin aktarması açısından masalların gücü önem teşkil etmektedir. Özellikle küçük yaş gruplarında temel değerlerin aktarımında kullanılan hayvan masallarının bu hususta bir araç niteliğine sahip olduğu görülmektedir.
GELENEKSEL AFYONKARAHİSAR EVLERİNDE CEPHE DÜZENLEMELERİ
Authors: KUNDURACI Osman , BAHARGÜLÜ Nurcan
Published: January 2019

Türkler; başta Anadolu olmak üzere gittikleri her bölgenin şartlarına uygun ve kendilerine özgü nitelikli konutlar inşa etmişlerdir. Bu evler insanların fiziksel ölçülerine uygun, işlevsel ve estetik değerleriyle bir bütün halinde ortaya konulmuştur.Ege Bölgesi’nin İç Anadolu sınırında yer alan Afyonkarahisar, bu konumuyla Marmara ve Orta Anadolu bölgelerini Ege ve Akdeniz bölgelerine bağlayarak doğu ile batı, kuzey ile güney arasında bir köprü görevi üstlenmiştir. İç Anadolu’ya daha yakın olmasına rağmen sosyal, kültürel, ekonomik, sanat ve mimarlık açısından Ege ile Orta Anadolu’nun sentezi durumundadır.Afyonkarahisar eski kent dokusu içinde kalan ve çoğu tescilli Geleneksel Afyonkarahisar evleri daha çok Afyonkarahisar kalesinin eteklerinde ve Ulu Caminin etrafında toplanmıştır. Geleneksel Afyonkarahisar evleri genellikle iki ve üç katlı olarak inşa edilmiştir.Evlerin yan yana dizilmesi ve girişlerinin çoğunun sokağa bakması derinlik duygusunu artırmaktadır. Bu bağlamda Geleneksel Afyonkarahisar evlerinin kendine özgü cephe mimarisi ve buna bağlı olarak süsleme anlayışı bulunmaktadır.Özellikle evlerin giriş düzenlemeleri, saçakları, pencere ve kapı tasarımları, elibelindeler ile diğer taşıyıcı elemanlar ve katları belirleyen ahşap hatıllar cepheyi hareketlendiren unsurlardır. Ayrıca bu evlerin çatı seviyesinde cihannümalarının olması, pencerelerdeki ferforje ve ahşap kafesler, bazı elibelindelerdeki yürek motifleri, madeni kapı kolları ve tokmakları ile de kendine özgü tasarımları dikkat çekicidir.Bu yüzden Geleneksel Afyonkarahisar evleri yakın çevresinde bulunan diğer evlerden farklı tasarım ve süslemeleriyle özgün örneklerdir. Bu çalışma ile Geleneksel Afyonkarahisar evlerinden sadece merkezde bulunan sınırlı sayıda örnek ele alınmıştır. Ulu camii çevresindeki cadde ve sokaklardan seçilen bazı evler incelenmiştir. Bu örnekler kendi içinde gruplandırılarak fotoğraflar ve çizimler ile desteklenerek Geleneksel Afyonkarahisar evlerinin Türk sivil mimarisindeki yeri ve önemi ortaya konmaya çalışılmıştır.
Potato ecological quality in the biologization of high-intensity technologies of its cultivation and irrigation
Authors: Бутов Алексей , Butov Alexey , Мандрова Анна , Mandrova Anna
Published: January 2019

To reduce the accumulation of toxic substances in tubers in 2014–2016 the author studied biological methods of fertilizers application and plant protection in black earth forest-steppe region under the conditions of high-intensity potato cultivation technology along with drip irrigation. The introduction describes the importance of potato in the diet of population and lists the environmental issues that arise as a result of enhanced using of chemicals during crop cultivation. The doses of mineral fertilizers in experiments were introduced separately and in combination with a bioameliorant: 1) without fertilizers (control site); 2) N60P90K60; 3) N90P135K90;

4) N120P180K120; 5) biological ameliorant – white mustard, post-harvest green manure; 6) bioameliorant + N60P90K60; 7) bioameliorant + N90P135K90; 8) bioameliorant + N120P180K120. Chemical insecticide Aktara and biological preparations Fitoverm, Akarin were used to protect potatoes against Colorado potato beetles. Insecto-fungicide Celest was used to treat seed tubers against fungal diseases. During growing season the author used fungicides Profit Gold, Ridomil Gold against fungal diseases, against weeds – Zenkor and Remus. High yield of potato environmentally friendly considering nitrates was obtained by means of simultaneous application of N90P135K90 and white mustard green mass. Tuber yield was 40.4 tonnes per hectare compared to 22.7 tonnes per hectare on the control site, and nitrate content was 111.3 mg while maximum permissible concentration (MPC) is 250 mg/kg. According to MPC established in the Russian Federation, for childrenʼs and dietary nutrition fertilizer dose should not exceed N60P90K60 in combination with a bioameliorant and a biological plant protection system. Safety interval (period between plant treatment and harvesting) for chemical insecticides is 35–40 days; fungicides – 20 days; herbicides (depending on their type) – 55–70 days. The production of ecologically clean potato according to EU standards was achieved only by means of using post-harvest green manure as a fertilizer, applying biological insecticides and Celest preparation within the framework of protecting plants against pests and diseases.
Dependence between sterols synthesis and the method of beer yeast oxygenation
Authors: Пермякова Лариса , Permyakova Larisa
Published: January 2019

Oxygen is necessary for yeast to synthesize membrane components (unsaturated fatty acids and sterols), but its high content in the medium during fermentation increases the concentration of cell oxidative metabolism products. This slows down beer maturation process and impairs its quality. The alternative way is to aerate the inoculum to accumulate sterols in cells and reduce the cells’ requirement for oxygen. The author studied the effect of inoculum preparation conditions and oxygen content in the fermentation medium on the formation of sterols by the brewer’s yeast Saccharomyces cerevisiae. Pre-fermentation treatment involved a short aeration of the inoculum (for 30 min) in water, beer wort or young beer with further exposure in an anaerobic environment (for 1–3 hours). The content of sterols was evaluated by means of spectrophotometry, chromatography-mass spectrometry, thin-layer chromatography (TLC), and gas-liquid chromatography (GLC). The article reveals that when yeasts are aerated in young beer, cells synthesize by 16% and 73% more sterols than in water and wort, respectively. This is due to the presence of carbon sources in beer which are effective for sterols synthesis. After application of any method for providing yeast with oxygen (at culture preparation or wort fermentation stage) six components were detected in the unsaponifiable fraction using TLC: ergosterol, ergosta-5,7-diene-3β-ol, ergosta-7,22-diene-3β-ol, fecosterol, zymosterol, lanosterol. GLC revealed five compounds: squalene (39–54%), lanosterol, 24 (28) -dihydroergosterol, ergosterol (23–35%) and an unidentified component which according to mass spectrometry was 24-methylene-24,25-dihydrolanosterol. An increase in the oxygen level in the fermentation medium from 4.0 to 16.0 mg/l contributes to the decrease in sterols accumulation per unit of oxygen consumed by the yeast. Preliminary aerationallowed yeast to multiply regularly at oxygen concentration in the fermentable wort of 4.0 mg/l and ferment the extract of the medium at the level of the sample where oxygen content was 8.0 mg/l. This shows the advantage of using yeast pre-fermentation aeration and conducting beer wort fermentation process without additional saturation with oxygen.
Efficient maintenance method for water supply facilities focused on the carbonation of concrete
Authors: Fujita Masaki , Iwasaki Shoichi , Inoko Keinosuke , Hayashi Kenji
Published: January 2019

In water supply facilities such as distribution reservoirs, the inner surface of reinforced concrete (RC) tanks is often coated with resin paint or the concrete cover depth is increased to protect the concrete from surface deterioration. However, there is little published research on carbonation – one of the main causes of concrete deterioration – in relation to RC tanks, leaving room for improvement with regard to methods for preventing surface deterioration. This study discusses the impact of surface coating and environmental conditions on the carbonation rate of concrete based on a survey of the present state of RC tanks of the Sapporo Waterworks Bureau. Coating was found to have an inhibitory effect on carbonation. Because the carbonation rate of concrete used for the inside and outside of RC tanks was slow, the sufficient concrete cover depth to protect rebar from carbonation while in service was found to be 75 mm for RC tanks without coating.
Selenium in wastewater: fast analysis method development and advanced oxidation treatment applications
Authors: Mohapatra Dipti Prakash , Kirpalani Deepak M.
Published: January 2019

Selenium, a ubiquitous non-metal in nature, is potentially toxic to natural ecosystems due to its bioaccumulation potential. Due to increased monitoring and enforcement of selenium regulations, the need to be able to measure and treat selenium efficiently has taken on an increased importance. The principal aqueous forms of inorganic selenium are selenite (Se(IV)) and selenate (Se(VI)). Selenate, due to its high mobility and lack of affinity to conventional adsorbents, is typically much more difficult to treat and remove. To address both measurement and removal, an analytical method is reported for quantification of selenium in wastewater (WW) using UV-Vis spectrophotometer followed by removal studies using advanced oxidation processes (AOPs). Malachite green and azure blue were selected for colorimetric analysis using UV-Vis. Malachite green indicator showed the best results for analysis. The reported UV-Vis method was applied to establish the effect of AOPs on selenium removal. It was noted that all of the AOP treated samples showed removal of selenium and it was established that the UV-Vis method has a lower limit of detection at 2 mg/L. Further, through this study, it was found that the chemical cavitation yield and selenium removal efficiency peaked at low frequency ultrasound of 40 kHz.
Bioinformatics Study of RNA Interference on the Effect of HIF-1α on Apelin Expression in Nasopharyngeal Carcinoma Cells
Authors: Xu Gang , Li Xianming , Yang Dong , Wu Shihai , Wu Dong , Yan Maosheng
Published: January 2019

Background:

HIF-1α can affect the apelin expression and participates in the
developments in cancers but the mechanism need to be explored further.

Objective:

This paper investigates apelin expression in nasopharyngeal carcinoma CNE-2 cells and
its regulation by hypoxia inducible factor-1α (HIF-1α) under hypoxic conditions.

Methods:

CoCl2 was used to induce hypoxia in CNE-2 cells for 12h, 24h and 48h. HIF-1α small
interference RNA (siRNA) was transfected into CNE-2 cells using a transient transfection method.
HIF-1α and apelin mRNA levels were detected by real time PCR. Western blot was used to
measure HIF-1α protein expression. The concentration of apelin in cell culture supernatant was
determined by enzyme linked immunosorbent assay (ELISA).

Results:

HIF-1α and apelin mRNA levels and protein expression in CNE-2 cells increased
gradually with increased duration of hypoxic exposure and were significantly reduced in HIF-1α
siRNA transfected cells exposed to the same hypoxic conditions.

Conclusion:

Apelin expression is induced by hypoxia and regulated by HIF-1α in CNE-2 cells.
Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder
Authors: Hroudová Jana , Fišar Zdeněk , Hansíková Hana , Kališová Lucie , Kitzlerová Eva , Zvěřová Martina , Lambertová Alena , Raboch Jiří
Published: January 2019

Objectives:

The bipolar affective disorder (BAD) pathophysiology is multifactorial and has
not been fully clarified.

Method:

We measured selected mitochondrial parameters in peripheral blood components. The analyses
were performed for patients suffering from a manic episode during remission and were compared
to those performed for healthy controls. BAD was clinically evaluated using well-established diagnostic
scales and questionnaires. Mitochondrial respiration was examined in intact and permeabilized
blood platelets using high-resolution respirometry. The citrate synthase (CS) and electron transport
system (ETS) complex (complex I, II, and IV) activities were examined in platelets.

Results:

The CS, complex II and complex IV activities were decreased in the BAD patients, complex I
activity was increased, and the ratio of complex I to CS was significantly increased. In the intact platelets,
respiration after complex I inhibition and residual oxygen consumption were decreased in the
BAD patients compared to the healthy controls. In the permeabilized platelets, a decreased ETS capacity
was found in the BAD patients. No significant differences were found between BAD patients in
mania and remission.

Conclusion:

Increased complex I activity can be a compensatory mechanism for decreased CS and
complex II and IV activities. We conclude that complex I and its abnormal activity contribute to defects
in cellular energy metabolism during a manic episode and that the deficiency in the complex's
functioning, but not the availability of oxidative phosphorylation substrates, seems to be responsible
for the decreased ETS capacity in BAD patients. The observed parameters can be further evaluated as
‘trait’ markers of BAD.
Nickel Sensitivity in Rosacea Patients: A Prospective Case Control Study
Authors: Çifci Nurşad
Published: January 2019

Background:

Rosacea is a frequently seen chronic disease. Certain allergens, some foods
and beverages are known to trigger symptoms of rosacea.

Objective:

We aimed to assess if nickel sensitivity is more common in rosacea patients than the normal
population.

Method:

Fourty patients with rosacea and 40 healthy age and sex-matched volunteers were included in
the study. From European standard patch test series, test units with nickel were applied on the skin of
the upper back. According to the scheme of the International Contact Dermatitis Research Group
(ICDRG), test results were evaluated at 48th, 72th and 96th hours. Seven days later, reevaluation was
done for late reactions. Statistical analyses were done by using Statistics package for Social Sciences
(SPSS) 17 package program and p<0.05 was accepted as statistically significant.

Results:

Female/male ratio was 34/6 in patient group and 32/8 in control group. Mean age of the
patient group and the control group were 39.97±12.65 (18-65 years), 40.82±11.79 (19-68 years), respectively.
Age and sex distributions were found to be statistically similar. Nickel allergy in the patient
and control group was found to be 52.5%, 22.5% respectively and the difference between groups was
statistically significant (p=0. 006).

Conclusion:

Our results showed that there may be an association between nickel sensitivity and rosacea.
Nickel sensitivity may be one of the underlying pathology or a triggering factor of the rosacea.
Nickel restricted diet and avoiding the use of nickel-containing jewellery and piercings may extend the
remission periods.
Instantaneous Incident Detection System Based on Analysis of Acoustic Signal from Crash and Skid in Tunnel
Authors: Jang Jinhwan
Published: January 2019

Introduction:

An acoustic signal-based tunnel accident detection system was developed in this study. In a tunnel environment, the sound diffusion effect is minimized and thanks to that, discrimination of accident sounds (crash and skid) from other noises can apparently be accomplished.

Discussion:

The system is composed of three parts: algorithm, field device, and center system. To distinguish accident-related acoustic signals such as a crash or skid among various other sounds in a tunnel, a delicate algorithm that can discriminate those signals from other normal signals generated from moving vehicles was created.

Conclusion:

The developed algorithm processes acoustic signals to filter out noises and to identify accident-related signals. The field device, installed in a tunnel, collects analog sounds, transforms them into digital signals, and transmits the digital signals to the server in the tunnel traffic management center. Lastly, in the tunnel traffic management center, the acoustic signal processing algorithm described above, installed in a server system, can instantaneously detect accidents. Once confirmed by the system operators, the information on the detected accidents is intended to be provided to drivers following behind as well as relevant agencies to prevent secondary accidents and to respond promptly. The developed system was evaluated in a real tunnel environment using traffic accident sounds acquired from real crash tests. The detection rates were 95, 91, and 80% at distances of 10, 30, and 50 m, respectively with a detection duration less than 1.4 s. Compared to conventional detection systems using loop detectors or video images that have a long detection time of around 1 min, the developed system can be regarded as superior in that it has an extremely short detection time, which, of course, is one of the most important factors for automatic incident detection systems.
Efficient Cell-Wall Disruption of Microalgae Chlorella Vulgaris in water by catalytic ozonation over Microporous Carbon-Supported Titanium Oxide
Authors: Rame Rame , Nilawati Nilawati , Silvy Djayanti Silvy , Irnaning Handayani Novarina , Purwanto Agus , Ruliaty Lisa , Dwi Harjanto Ganang
Published: January 2019

This study investigated several parameters for cell-wall disruption from microalgae Chlorella vulgaris during catalytic ozonation over microporous carbon-supported titanium oxide, including flow ozone, catalytic time, and reactor capacity. At the same time, the cell-wall disruption yield and an active compound yield such as chlorophyll and carotenoid were evaluated for each pretreatment. The required delivered flow ozone to achieve 76,47% cell-wall disruption of Chlorella vulgaris was 1 minute at 4 LPM, which produced chlorophyll 56,75% and carotenoid 89,09%. Carbon-supported titanium oxide reduces the required O3 dose and catalytic time for cell-wall disruption; however, it limited chlorophyll yield did not exceed 75,67%. Pretreatment with 1 minute at 1 LPM in 2 liters produced carotenoid yield by approximately 98,18%, though it reduced chlorophyll to 59,45%.