bluuebunny/crossref_metadata_2025 huggingface dataset:
A gestão da propriedade intelectual nas instituições públicas de ensino superior mineiras
Authors: Fujita Allynson Takehiro , Mata Jhansley Ferreira da , Sousa Larissa Campos
Published: December 2023

Resumo: O estudo aborda a concessão de patentes em instituições públicas de ensino superior em Minas Gerais, focando nos depósitos feitos pelos Núcleos de Inovações Tecnológicas (NITs). O objetivo é analisar os pedidos de patentes, incluindo concessões, rejeições e a presença de inovação frugal nas tecnologias. O objetivo central é examinar os depósitos de pedidos de patentes feitos por estas instituições no estado, independentemente da concessão final das patentes. A pesquisa utiliza lógica operacional, método dedutivo e abordagem qualitativa para coletar informações das instituições e realizar a análise. Além disso, foi possível perceber que a Universidade do Estado de Minas Gerais possui 1218 patentes depositadas junto ao INPI, estando à frente das demais instituições públicas mineiras quanto as patentes concedidas. Já a UFLA teve o maior número de pedidos de patentes indeferidas. O NIT da UFSJ foi o que apresentou o maior número de patentes com viés em inovação frugal depositadas.
Graduate students’ and master’s students’ perceptions regarding the educational product in a professional graduate program
Authors: Jurdi Andrea Perosa Saigh , Chriguer Rosangela Soares , Zihlmann Karina Franco , Tambeiro Dafne Komora , Mazzaia Maria Cristina
Published: December 2023

Abstract Educational products (EP) have been a structuring aspect in investigations and interventions proposed by professional master’s or doctoral research. The aim is to present and discuss the results of research carried out on the perceptions of master’s students and graduate students from the Master in Health Sciences Teaching Program (PPGESC) - professional format on the processes of constructing EP. A questionnaire with closed- and open-ended questions was used. And 46.8% of master’s students and 17.7% of graduate students enrolled between 2017-2020 answered the questionnaire. For 53.8% of graduate students and 29.8% of master’s students, EP emerged after the results obtained from the research. Regarding the definition of EP, 32.4% of master’s students defined it as a resource to be developed with expectations of intervention in professional practice. In relation to the types and nature of the EP prepared, professional training courses were most cited (27% of master’s students and 34.6% of graduate students). The heterogeneity of conceptions and conduct regarding EP construction and implementation stood out. Limitations of this study refer to the difficulty in accessing PPGESC graduate students and the need for a monitoring instrument. It is expected to contribute to improving the EP preparation process within professional teaching programs.
Matrix Metalloproteinase-7 in Urinary Extracellular Vesicles Identifies Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease
Authors: van Heugten Martijn H. , Blijdorp Charles J. , Arjune Sita , van Willigenburg Hester , Bezstarosti Karel , Demmers Jeroen A.A. , Musterd-Bhaggoe Usha , Meijer Esther , Gansevoort Ron T. , Zietse Robert , Hayat Sikander , Kramann Rafael , Müller Roman-Ulrich , Salih Mahdi , Hoorn Ewout J.
Published: December 2023

Significance Statement

There is an unmet need for biomarkers of disease progression in autosomal dominant polycystic kidney disease (ADPKD). This study investigated urinary extracellular vesicles (uEVs) as a source of such biomarkers. Proteomic analysis of uEVs identified matrix metalloproteinase 7 (MMP-7) as a biomarker predictive of rapid disease progression. In validation studies, MMP-7 was predictive in uEVs but not in whole urine, possibly because uEVs are primarily secreted by tubular epithelial cells. Indeed, single-nucleus RNA sequencing showed that MMP-7 was especially increased in proximal tubule and thick ascending limb cells, which were further characterized by a profibrotic phenotype. Together, these data suggest that MMP-7 is a biologically plausible and promising uEV biomarker for rapid disease progression in ADPKD.

Background

In ADPKD, there is an unmet need for early markers of rapid disease progression to facilitate counseling and selection for kidney-protective therapy. Our aim was to identify markers for rapid disease progression in uEVs.

Methods

Six paired case–control groups (n=10–59/group) of cases with rapid disease progression and controls with stable disease were formed from two independent ADPKD cohorts, with matching by age, sex, total kidney volume, and genetic variant. Candidate uEV biomarkers were identified by mass spectrometry and further analyzed using immunoblotting and an ELISA. Single-nucleus RNA sequencing of healthy and ADPKD tissue was used to identify the cellular origin of the uEV biomarker.

Results

In the discovery proteomics experiments, the protein abundance of MMP-7 was significantly higher in uEVs of patients with rapid disease progression compared with stable disease. In the validation groups, a significant >2-fold increase in uEV-MMP-7 in patients with rapid disease progression was confirmed using immunoblotting. By contrast, no significant difference in MMP-7 was found in whole urine using ELISA. Compared with healthy kidney tissue, ADPKD tissue had significantly higher MMP-7 expression in proximal tubule and thick ascending limb cells with a profibrotic phenotype.

Conclusions

Among patients with ADPKD, rapid disease progressors have higher uEV-associated MMP-7. Our findings also suggest that MMP-7 is a biologically plausible biomarker for more rapid disease progression.
The Effects of Oxygen Availability in the Seed Container during Storage on Seed Germination in Tomato, Onion, Cabbage, and Marrow Seeds
Authors: Kadıoglu Neslihan , Demir İbrahim
Published: December 2023

This research was conducted to test the effect of oxygen content (low O2, high O2, air) during hermetic seed storage at 20±2°C over 8 and 12 months on seed germination and seedling root and shoot length in tomato, onion, cabbage, and marrow seeds. Samples with low oxygen storage had higher seed germination as well as longer root and shoot lengths than both control and high oxygen storage. When the storage period extended from 8 to 12 months, the germination percentages also reduced. However, these results varied among the species. The greatest advantage of low oxygen storage was obtained in tomatoes, which exhibited 15% and 9% higher germination compared to the control after 8 and 12 months of storage, respectively. The longest root and shoot lengths of 6.4 cm and 11.6 cm, respectively, were obtained from the low oxygen storage treatments. A similar positive effect of low oxygen storage was observed in onion and cabbage seeds but not in marrows. Results indicated that oxygen level in the packets during storage can be an effective component to maintain high seed germination and seedling growth potential (seed vigour). The difference in the effect on different species is a matter of further research.
Pseudosarcoptic mange in a child. Case from practice
Authors: Sagitova G. R. , Antonova A. A. , Smirnova E. V. , Sereda V. M.
Published: December 2023

The article describes a clinical case of pseudoscabies. The parents of the child G., 10 yearsт old, turned to the pediatrician at the place of residence with complaints about sluggish and long-lasting rashes in the neck area on the left. The boy has been ill for two months. He was observed by a dermatovenereologist with suspected allergic dermatitis, received treatment with desensitizing drugs and corticosteroids. It was noteworthy that on the skin of the neck on the left, multiple papules of a rounded shape, pink in color were visualized, some of them were covered with hemorrhagic crusts. Due to the lack of effect from therapy and due to the fact that pseudo-scabies was suspected, a 10 % sodium benzyl benzoate ointment was prescribed. On the 4th day from the start of therapy, there was a positive trend. Thus, this clinical case is of practical interest for attracting the attention of doctors to a thorough history taking, searching for the causes leading to a protracted course of the disease and timely change of treatment regimen.
Effects of influenza vaccination on the morbidity and severity of COVID-19 in children
Authors: Ponomareva Yu. V. , Shisimorov I. N. , Magnitskaya O. V. , Plakhotnyuk T. V. , Krasnova K. Sh.
Published: December 2023

The pandemic of a new coronavirus infection COVID-19 initiated research to find methods of non-specific influence on the immune system that can change the course of infectious diseases. Adult study results have been demonstrated the positive effect of seasonal influenza vaccination on morbidity, hospitalization rates, and reducing the severe forms of SARS-CoV-2 infection. That suggests a similar action in children.

   The aim of the study: to establish the possible impact of influenza vaccination on the morbidity and severity of COVID-19 in children in Volgograd.

   Materials and methods. The 303 children 3-17 years old without a history of chronic diseases were included in comparative prospective cohort study on the impact of influenza vaccination (235/303) on morbidity and severity of a new coronavirus infection COVID-19 vs non-vaccinated group (68/303).

   Results. All children with new coronavirus infection COVID-19 (diagnosis confirmed by laboratory testing - U07.1) had mild symptoms of the disease. In all age groups, the morbidity and the severity of the new coronavirus infection COVID-19 among children vaccinated against influenza did not have significant differences with non-vaccinated group.

   Conclusion. The results of our study did not support the hypothesis of a protective role of seasonal influenza vaccination on the morbidity and severity of COVID-19 in healthy children. Further research is needed to establish the effect of influenza vaccination on the severity of COVID-19 in children with chronic diseases.
Klimawandel und Gesundheit (Folge 1): Auswirkungen des Klimawandels auf den Hautschutz
Authors:   Peter Greven Physioderm (PGP), Euskirchen, Kemme Susanne
Published: December 2023

Die Erderwärmung beeinflusst den Arbeitsschutz im Allgemeinen und den beruflichen Hautschutz im Besonderen auf vielfältige Weise. So führt das wärmere Klima zu erhöhter Hitze- und solarer UV-Belastung – vor allem bei Arbeiten im Freien. Zudem treten auch bei uns immer mehr exotische Mückenarten auf, die gefährliche Krankheitserreger übertragen. UV- und Insektenschutz werden demnach künftig noch weitaus mehr in den Fokus geraten.
Gesundheitsförderliche Gestaltung von Digitalisierungsprozessen in Organisationen – Wissenschaftlicher Überblick von Anforderungen und Unterstützungsfaktoren für Beschäftigte
Authors:   Zentralinstitut für Arbeitsmedizin und Maritime Medizin – ZfAM), Universitätsklinikum Hamburg-Eppendorf (UKE), Wirth Tanja , Mache Stefanie ,   Zentralinstitut für Arbeitsmedizin und Maritime Medizin – ZfAM), Universitätsklinikum Hamburg-Eppendorf (UKE)
Published: December 2023

Designing health-promoting digitalisation processes in organisations: Scientific overview of demands and support factors for employees Objective: Digitalisation processes can bring about far-reaching changes in how work is organised and influence the working conditions of employees. This review article examines the demands and support factors which employees experience in the course of such digitalisation processes and how these can be designed in a way that promotes health. Methods: A systematic literature search in the PubMed and Web of Science databases was conducted. German and English-language studies published from the year 2013 onwards which examined specific digitalisation measures/projects in companies or public institutions and described results on the impact of digitalisation processes on employees or with regard to process design were included. The results were presented as a qualitative summary. Results: Overall, nine studies were included in the review. A lack of goals, strategies and responsibilities for the implementation of digitalisation measures, a lack of transparency, increased workload as well as insufficient support and time resources can be perceived as demanding by employees. Conversely, comprehensive information, active involvement, the provision of training and support at technical level and by supervisors comprise support factors in the process. Accordingly, the preparation and organisation of the process, personnel resources, support measures, participation and communication offer relevant opportunities for a health-promoting design of the digitalisation project. Conclusions: Organisations should consider and help shape potential impacts of digitalisation processes for their employees right from the beginning of the measure. This can be achieved by understanding the implementation of digitalisation measures as a holistic process which requires change management and change leadership. Keywords: digitalisation – digital transformation – change management – workplace health promotion
Psychische Belastungen und berufliche Mobilitätsunfälle
Authors:   Lehrstuhl für Arbeits-, Betriebs- und Organisationspsychologie, Friedrich-Schiller-Universität Jena, Mohr Yannic , Trimpop Rüdiger ,   Lehrstuhl für Arbeits-, Betriebs- und Organisationspsychologie, Friedrich-Schiller-Universität Jena
Published: December 2023

Mental stress and occupational mobility accidents – What can organisations and employees do about the number one cause of death in the workplace? Mobility accidents are the most frequent cause of death in the work context. With regard to participation in road traffic, numerous risk factors in terms of technology and environment, organisation, the person and the situation are known to be psychological strains which exercise an influence on the probability of accidents. Nevertheless, traffic participation as part of the occupational activity is little considered in risk assessments and the issue of road safety plays almost no role in the organisational context. After a classification of the relevance, therefore, this overview presents a framework model for the systematic observation of hazards and the resulting mental stress in the context of occupational mobility. This is followed by an overview of the most relevant empirically proven risk factors in the context of traffic participation. Finally, a free and proven instrument of the accident insurance institutions and the German Road Safety Council for hazard assessment and the risk evaluation of organisational mobility (GUROM) is presented, as well as other measures for organisations that have been empirically proven to be successful. It is very much hoped that many readers and managerial staff in companies will be inspired and take the opportunity to do something about the number one killer in the working world. Keywords: mental stress – occupational mobility – road safety – risk assessment – GUROM
Assessment of the Quality of Public Services in the Field of Employment in the Context of Quarantine Restrictions
Authors: Nosyreva Irina , Beloborodova Nina
Published: December 2023

The state has long been engaged in evaluating and improving the quality of public services. Users of public services should be actively involved in this process. Currently, this opportunity is provided by the digitalization of the economy. For this purpose, several Internet resources have been developed, telephone and questionnaire surveys, and SMS voting are conducted. This has undoubtedly reduced the time between the provision of services and the assessment of their quality, increased the speed of response to rejections, and as a result, improved the quality of public services. However, the issue of full coverage of the target audience remains unresolved. If public services are evaluated in a large volume, the services provided by municipal institutions are not always evaluated by consumers. The article attempts to assess the quality of services provided by the territorial employment center of the Irkutsk region from the point of view of consumers (the unemployed). The purpose of the study is to study the opinion of the consumers and their recommendations to improve the quality of these services in the context of a pandemic, when a state institution operates in a closed format. During the questionnaire survey, interesting conclusions were obtained about the quality of public services. It was revealed that the most popular service of the employment center was social support for the unemployed. The respondents indicated the availability and high level of services provided, and the competence of the staff. The needs of the population that were not fully met were also identified.
Improving the Logistics of Maritime Container Transportation in the Context of Financial Sanctions
Authors: Ibragimkhalilova Tatyana , Boyko Svetlana
Published: December 2023

The study analyzed the development of container transportation in the face of financial instability, challenges and risks. We proposed the directions of interaction between economic entities at the international level, including in terms of logistics processes. We studied the impact of sanctions on the container / liner shipping market, the number of ships, and total capacity of container ships of companies included in the top 10 Alphaliner ratings. Russia imports ingredients for food and chemical industries, components for the automotive industry and other mechanical engineering, household appliances, consumer goods and exports products of the timber industry complex, fertilizers, non-ferrous metals, petrochemicals and other goods. The study revealed that the flow of sanctions affects not only the Russian econo­my, but also exports of products that are significant for the West. When building international supply chains, it is important to reorient the vector of interaction towards Chinese transport companies that are actively integrating into the Russian market. The study highlighted competitive advantages and disadvantages for each transport company. Based on the results of the study, we identified strategic guidelines for the development of the container transportation market of the Russian Federation considering the needs of economic entities. Provided that the new project will meet modern world requirements for the quality of services provided, the payback of significant capital investments is predicted in the shortest possible time.
Adatok a Duna–Tisza köze flórájának ismeretéhez
Authors: Süveges Kristóf
Published: December 2023

Jelen dolgozatban a Duna–Tisza közén a közelmúltban megfigyelt florisztikai adataimat adom közre. Összesen 117 edényes növényfaj előfordulásait mutatom be, melyek közül 27 vé dett, 3 fokozottan védett faj. Mivel a Duna–Tisza köze tájképileg meglehetősen változatos régió, ezért adataim is igen sokféle élőhelyről származnak: zavart és természetes száraz-, mezofil- és üde gye pek, erdőszegélyek, különböző gyomtársulások. Emellett jelentős számú adatot közlök többféle másod lagos élőhelyekről is: telepített erdők, temetők, épületek, vasút menti élőhelyek, rézsűk, mezsgyék, kiszáradt csatornamedrek, vízzel telt csatornák, illetve urbán környezetben található ruderális élőhelyek. Adataim összesen kilenc kistáj területét érintik, melyek közül a legfontosabbak a Bácskai löszös síkság, a Bugaci-homokhát, a Dorozsma–Majsai-homokhát, a Kiskunsági-homokhát és a Kiskunsági löszös hát. Védett növények közül érdemes kiemelni a következő fajok újabb előfordulási adatait: Apium repens, Epipactis bugacensis, E. atrorubens, Ophrys sphegodes, Muscari botryoides, Ranunculus illyricus, Vicia biennis. Növényföldrajzi szempontból legjelentősebb a Galium tenuissimum, G. parisiense, Spiranthes spiralis és Bifora radians egy-egy új adata a Kiskunságban, illetve az Ornithogalum refractum jellemző előfordulása a Praematricum területén. Másodlagos élőhelyről öt páfrányfaj jelenlétét mutatom be, melyek közül egynek (Asplenium ceterach) nem volt korábbi adata az Alföldről. Közlöm néhány idegenhonos faj újabb lokalitását is; ezek egy részének országos szinten is alig ismert néhány előfordulása vagy irodalmi adata (Echium plantagineum, Persicaria orientalis, Periploca graeca), illetve jónéhányuk a Duna–Tisza köze szempontjából számít kevéssé ismertnek (pl. Lepidium densiflorum, L. virginicum, Geranium purpureum, Taeniatherum caput-medusae, Humulus scandens). A közlemény számos olyan faj előfordulását is tárgyalja, melyeknek az adott térségből vagy kistájból nem volt korábbi adatuk, vagy csak archív adataik ismertek, esetleg adathiányosak (Alcea biennis, Arabis glabra, Arctium minus, Chenopodium botrys, Ch. murale, Herniaria incana, Melilotus dentatus, Potentilla inclinata, Reseda luteola, Vicia pannonica subsp. striata, Vulpia myuros stb.). Ezek mellett né hány hínárfaj új adatát is közlöm a Duna–Tisza közéről (pl.: Najas marina, Lemna gibba, Wolffia arrhiza).
BUDGET TRANSPARENCY AND DEBT OF CITIES IN CROATIA
Authors:   Institut za javne financije, Prijaković Simona
Published: December 2023

Ovaj rad analizira vezu razine online proračunske transparentnosti (OPT) i direktni dug gradova u Republici Hrvatskoj. OPT se mjeri Indeksima otvorenosti lokalnih proračuna OLBI i OLBI+ (engl. Online Local Budget Index), a zaduženost direktnim dugom po stanovniku, udjelom direktnog duga u ukupnim prihodima i udjelom direktnog duga u ukupnim rashodima. Cilj rada je empirijski utvrditi moguće klastere, odnosno grupirati sve hrvatske gradove, ovisno o njihovim razinama OPT-a i zaduženosti. Klaster analiza obuhvaća svih 128 hrvatskih gradova u razdoblju od 2019. do 2021. Rezultati pokazuju da gradovi s nižim razinama OPT-a imaju više iznose direktnog duga, više neplaćenih dospjelih obveza i višu stopu nezaposlenosti. Nadalje, gradovi s nižim razinama OPT-a imaju manje stanovnika, manje dohotka po stanovniku te manju političku konkurenciju. Ovo istraživanje predstavlja prvu analizu veze OPT-a i duga na nižim razinama vlasti; rezultati klaster analize ukazuju da je potrebno objavljivati više proračunskih dokumenata kako bi građani mogli sudjelovati u proračunskom procesu te bi se posljedično smanjivala razina direktnog duga gradova.
PENSION LITERACY OF STUDENTS AT THE UNIVERSITY OF ZAGREB
Authors:   Sveučilište u Zagrebu, Ekonomski fakultet, Anđelinović Mihovil , Pavković Ana , Šoštarić Antonio
Published: December 2023

Mirovinska pismenost predstavlja skup znanja, stavova, ponašanja i vještina vezanih uz mirovine i mirovinski sustav koje su pojedincu neophodne kako bi donio optimalnu odluku o vlastitom umirovljenju. Cilj ovog rada je proučiti mirovinsku pismenost studenata Sveučilišta u Zagrebu te, analizirajući znanje, ponašanje i stavove studenata o mirovinama i mirovinskom sustavu, identificirati najveće slabosti studenata u ovom području i prostor za daljnje opismenjivanje. U okviru rada provedeno je anketno istraživanje na uzorku od 2.100 studenata te intervju dviju fokus grupa koje su činili ekonomisti i neekonomisti. Rezultati intervjua fokus grupa ukazuju na znatnu divergenciju u stavovima i znanju između studenata Ekonomskog fakulteta i ostalih studenata, pri čemu su neekonomisti pokazali i mali interes za ovom tematikom. Nalazi anketnog istraživanja potvrđuju zaključak o relativno niskoj razini znanja i praktičnog znanja o mirovinama.
PREDIKCIJA USPJEŠNOSTI STUDENATA PRIMJENOM UMJETNIH NEURONSKIH MREŽA
Authors:   A1 Hrvatska d.o.o., Ljubičić Teo , Hell Marko
Published: December 2023

Višegodišnja elektronička obrada podataka omogućila je pohranu velike količine podataka koja se danas može iskoristiti za poboljšanje procesa u obrazovanju putem algoritama strojnog učenja. Koristeći se podacima iz sustava Moodle za učenje na daljinu, stvoren je model umjetne neuronske mreže s ciljem predviđanja konačnog ishoda studenta na kraju studija na temelju njegovih zaključnih ocjena prve godine studija. Kroz ukupno tri modela umjetne neuronske mreže pokazana je snaga ovog algoritma, gdje su svi modeli ostvarili vrlo nisku pogrešku, a najbolji rezultati postignuti su modelom umjetne neuronske mreže s dva skrivena sloja od devet neurona, čija je apsolutna greška iznosila 0,1920, a kvadratna pogreška 0,0562. Istraživanje pokazuje da su umjetne neuronske mreže vrlo učinkovite u predikciji konačnog ishoda studenata na temelju ocjena s prve godine studija te da takvi modeli imaju potencijal postati pomoćni alat i sredstvo donošenja odluka u obrazovnim institucijama.
FRICTION STIR WELDING (FSW) APPLICATION TO JOINTS ALUMINUM FOR SEVERAL RADIUS
Authors:   Sekolah Vokasi of Gadjah Mada University, Setiawan Widia , Santoso Nugroho ,   Sekolah Vokasi of Gadjah Mada University, Wiyadi Dr. ,   Sekolah Vokasi of Gadjah Mada University, Bahiudin Irfan ,   Sekolah Vokasi of Gadjah Mada University, Harjono Dr. ,   Sekolah Vokasi of Gadjah Mada University, Wismo Winarto Felixianus Eko ,   Sekolah Vokasi of Gadjah Mada University, Tarmudi Achsan ,   IST Akprind Yogyakarta
Published: December 2023

The FSW solid weld joint method can be used to joint several radius joints, which will be investigated for the strength of welded joints with 6061 aluminum material. with a size of 100 mm x 250 mm and a thickness of 5 mm, cut into a radius of 700mm, 900mm, 1000 mm, 1100mm, 1200 mm, and 1500 mm. The butt joint is joined by the friction stir welding (FSW) method using a milling machine. This experiment was carried out manually using universal milling with good results, it can be applied to modern machine buildings. The microstructure of the good results did not occur defects and manganese formed small balls in the FSW with a radius of 700 mm, the highest hardness test results occurred in the FSW with a radius of 1100 mm, namely 45 VHn, and the highest tensile strength occurred at a radius of 700 mm, which was 92 MPa.
DECISION-MAKING SUPPORT TECHNOLOGIES USING THE CAD/CAM/CAE SYSTEM DESIGN AND MANUFACTURE OF BONE SUBSTITUTES WITH FUNCTIONAL PROPERTIES
Authors:   Faculty of Manufacturing Technologies with a seat in Presov, Technical University of Kosice, PANDA ANTON , DYADYURA KOSTIANTYN ,   Department of Biomedical Engineering, Odesa Polytechnic National University, PROKOPOVICH IGOR ,   Department Of Design Information Technologies and Design, Odesa Polytechnic National University
Published: December 2023

Currently, the use of additive technologies for the production of bone substitutes determines the effectiveness of the latest methods of treatment and prosthetics in traumatic surgery, oncology, crania-maxillofacial surgery, dentistry, etc. The introduction of additive technologies is the result of the integration of medical visualization, in particular, based on the technologies of computer imaging, and engineering CAD/CAM/CAE systems. In connection with the increase in the number and severity of various types of bone tissue injuries received as a result of wounds during military operations in Ukraine, an important issue in orthopaedics and traumatology is making informed decisions about the possibility of restoring the integrity and functions of bone tissue when using different types of composition, the strength of biopolymer composites. The scientific aim of research is the development of principles and methods for making scientifically based decisions in the design and additive manufacturing of bone substitutes based on biopolymer composites with functional properties depending on the nature of the localization of the cavity bone defect and its size. The new knowledge will become the necessary basis for making optimal decisions in practice for the introduction of the latest methods of treatment and prosthetics in trauma surgery, oncology, crania-maxillofacial surgery, dentistry, taking into account the risks of biocompatibility of biopolymer composites. The results of the research will be used to design bone substitutes with controlled composition, structure, porosity, and mechanical strength for the further selection of additive technology for its production from apatite-polymer composites, which will contribute to increasing the efficiency of treatment and prosthetics in orthopaedics and traumatology.
Propuesta sostenible para la mitigación del riesgo de inundación en la cuenca alta del río Combeima municipio de Ibagué, Tolima.
Authors: Leal Cardenas Juan Sebastian , Triana Pulido Maria Liseth , Forero Buitrago Gonzalo Alberto
Published: December 2023

In recent decades, different phenomena and threats of climate variability have increased frequently in the country, since the increase in precipitation and the presence of long winter seasons produce negative effects on hydrological systems and generate a high level of vulnerability in populations. Thus, the objective of this research is to propose a sustainable proposal for flood risk control through the development of a methodology based on the implementation of Geographic Information Systems, Python language and WEAP in the upper Combeima river basin, municipality of Ibagué, Tolima. These computational tools allowed a detailed diagnosis of the study area and data processing of the hydrometeorological series reported by eleven IDEAM stations. Likewise, through the development of the hydrological model in WEAP, the historical behavior of the basin was analyzed, which allowed determining that, according to the characteristics and particularities of the area, the implementation of reservoirs and the key line design for reforestation with timber trees and rice crops, are the most relevant nature-based solutions to reduce the risk of flooding in the upper Combeima river basin. Where the reservoirs are designed to store approximately 428,660 m3 of water and the key line design for reforestation will allow the planting of more than 2,100 species between “frailejones” and timber trees.
Implementación de conceptos y herramientas de la filosofía Lean Construction en las empresas constructoras de la Ciudad de Cochabamba – Bolivia
Authors: Vergara Hinojosa Rodrigo , Cayo Chileno Nahúm Gamalier , Herrera Rosas Marialaura , Araoz Campos Alejandra , Aquino Rocha Joaquin Humberto
Published: December 2023

The objective of this study is to identify the strategies used by the construction companies of the city of Cochabamba-Bolivia in the execution of projects, considering the tools and concepts of Lean Construction. The methodology consisted of a survey of 63 companies in the city of Cochabamba-Bolivia through a questionnaire made up of 44 questions. Four aspects were consulted: a) profile of project managers, b) general company information, c) planning and execution of projects and d) knowledge of the Lean Construction philosophy. The results show that companies recognize the problems in productivity and generation of waste, but do not carry out specific solutions. On the other hand, companies have listened to and even implemented some Lean Construction tools; however, the majority (70%) do not know the philosophy. Although barriers to implementing the philosophy are identified, actions that can collaborate in its application are also highlighted, such as demonstrating results with benefits and training staff
Impacto socioeconómico de la refinería “Olmeca – Dos Bocas” en los sectores productivos en el municipio de Paraíso, Tabasco
Authors: Hernández-de-la-Cruz José Enrique , Juárez-Solís Sandra
Published: December 2023

Esta investigación permite conocer el interés del impacto que tienen los sectores productivos dentro de la economía del municipio de paraíso y determinar los cambios que los grandes proyectos tienen en la región. El objetivo de la presente investigación analiza el Impacto Socioeconómico de la Refinería “Olmeca – Dos Bocas” en los Sectores Productivos en el Municipio de Paraíso, Tabasco con la finalidad de observar el cambio que este proyecto provoca en los diferentes sectores productivos. Por ello se realiza una metodología con un enfoque cuantitativo, la cual, a través de una recolección de datos que permitió el desarrollo de un cuestionario que se le aplico a 50 personas entre los 3 sectores productivos expertas en el rubro, el cual tiene un alcance que evalúa el nivel de ingresos de la población de los sectores estudiados, así como el nivel de aportación socioeconómica que estos sectores generan al municipio. Se evidencia que el sector primario forja una aportación del 18,00% a la socioeconomía del municipio, el sector secundario un 29,00% y el sector terciario un 53,00% la cual genera un cambio socioeconómico. Finalmente, se llega a la conclusión de que una infraestructura como lo es la refinería “Olmeca - Dos Bocas” puede generar un cambio a nivel socioeconómico de una región. De manera que, la inversión en una infraestructura de gran envergadura genera cambios socioeconómicos de una población o en sus sectores productivos de dicha región.
A rare case of chondromyxoid fibroma of distal phalanx of great toe
Authors: Sharma Sachin , Kashyap Jyoti , Sharma Ankur , Dhiman Abhishek
Published: December 2023

Chondromyxoid fibroma (CMF) is rare benign tumour of bone which are due to incomplete cartilage differentiation and first described by Jaffe and Lichtensein in 1948. CMF’s constitutes for less than 1% of all bone tumors. Histopathology is diagnostic and CMF show lobulated areas of spindle shaped or stellate cells with hypocellular center of chondroid or myxoid material and periphery is hypercellular with abundant fibromyxoid tissue and few multinucleated osteoclasts like giant cell. CMFs are commonly seen in metaphysis of long bones including proximal tibia or distal femur. Short tubular bones of hand and feet are uncommon sites and toes constitutes less than 5% of the tumors. We present a case of chondromyxoid fibroma of distal phalanx of left great toe in 35 years old male patient.
Invasive solid papillary carcinoma of breast mimicking as a benign condition: Rare case report
Authors: Ramavath Krishna , Singh L Gopi , Sultana Reshmi , Sivakoti Sumitra , Adarsha A M  , Harikrishna B  , Rao Siddharth S
Published: December 2023

Invasive papillary carcinomas of breast are rare tumors. They account for approximately 0.5% of all Invasive breast carcinomas. Invasive papillary carcinomas are commonly present in post-menopause women. These tumors lack the myoepithelial cell layer (MCL) within the papillae or at the periphery of the tumor. The diagnosis is difficult due to different clinical and radiological features. Immunohistochemistry (IHC) is really essential to confirming the diagnosis. We are here presenting one index case of a rare variety of invasive papillary carcinoma of the left breast. We present a case of invasive papillary carcinoma of the left breast in a 55-year-old female presented with a retroareolar lump without nipple discharge. Preoperative core biopsy showed fibroadenoma with a papillary configuration.But post-operative histopathological examination revealed it was an invasive papillary carcinoma. Invasive papillary carcinoma of breast even though a rare entity, making a diagnosis is very challenging. Thorough preoperative clinical and radiological examination should be done, so that timely management as well as proper treatment is possible.
Mesenchymal Stem Cell Therapy for Ischemic Stroke in Animal Model: A Systematic Review
Authors: Aulia Muhammad Agus , Lestari Keri , Faried Ahmad , Sartika Cynthia Retna , Wijaya Andi , Adam Achmad , Gunawan Hanna , Haifa Rima , Naura Nabilla Farah , Pongajow Billy Yosua Costantin
Published: December 2023

BACKGROUND: Stroke is one of many leading causes of death and disability worldwide. Despite decades of research, treatment for stroke recovery is still inadequate. Recently, mesenchymal stem cell (MSC) therapy is considered as one of the potential treatments for stroke due to their capabilities to repair or regenerate damaged tissues, as well as immunomodulators in inflammatory conditions. Many pre-clinical and clinical trials have shown MSC therapy feasibility, safety, and efficacy in treating stroke. However, evidence regarding the optimal treatment plan and factors that can improve stem cell functional outcomes in treating stroke needs to be further explored. Therefore, a systematic review was conducted.METHODS: Recent literatures from 2015-2022 regarding stem cell therapies, specifically MSC on ischemic stroke, were collected from two reliable databases: PubMed and PubMed Central. Collected literatures were properly applied to inclusion-exclusion criteria and appraised critically. Keyword strategies on databases were employed, including both medical subject headings (MeSH).RESULTS: Five literatures from 726 were identified and used for systematic review. All animal model in the literatures were prepared to have middle cerebral artery occlusion. All studies indicated that MSC therapy is a safe and reliable procedure despite the variety of transplantation routes. No report of toxicity, rejection reaction, nor infection on MSC treated groups.CONCLUSION: Stem cell sources, dosages, and delivery routes could be resourceful for future translational studies to ensure the safety and efficacy of MSC therapy for ischemic stroke.KEYWORDS: ischemic stroke, mesenchymal stem cells, regenerative medicine, immunomodulator
Efficacy of Quinine Sulfate in Patients with Mild-To-Moderate COVID-19: A Randomized Controlled Trial
Authors: Latarissa Irma Rahayu , Barliana Melisa Intan , Meiliana Anna , Sormin Ida Paulina , Sugiono Erizal , Kartasasmita Cissy Bana , Irmansyah Irmansyah , Lestari Keri
Published: December 2023

BACKGROUND: Before WHO revoked the emergency use authorization for Chloroquine (CQ) and Hydroxychloroquine (HCQ) because of their side effects, it was suggested to use these two drugs for COVID-19 therapy. In addition, another derivate of quinine, namely Quinine Sulfate (QS), showed good in silico and in vitro antiviral activity against SARS-CoV-2. Prior the WHO revocation, this study was conducted to evaluate the efficacy of QS in mild-to-moderate COVID-19 patients.METHODS: This was an adaptive, controlled, multicenter, randomized, double-blind clinical trial involving mild-to-moderate COVID-19 patients in Indonesia. The participants were divided into 2 groups: the control group (standard COVID-19 treatment + placebo) and the treatment group (standard COVID-19 treatment + QS). The primary outcome was the efficacy of QS based on clinical status using a 7-point ordinal scale. The secondary outcomes were the efficacy of QS in terms of the incidence and duration of oxygen supplementation, incidence of mechanical ventilation, and length of stay.RESULTS: No significant difference in the efficacy parameters studied was found between the control group and the treatment group. The difference in the mean oxygen saturation was also measured and the results showed a significant difference where the treatment group had higher mean oxygen saturation than the control group (p=0.001).CONCLUSION: Although not significant, the treatment group showed better therapy outcomes compared to the control group.KEYWORDS: clinical trials, efficacy, quinine, chloroquine, hydroxychloroquine
Achatina fulica Mucus Ameliorates UVB-induced Human Dermal Fibroblast Photoaging via the TGF-β/Smad Pathway
Authors: Nuryana Christiana Tri , Agustin Tiara Puspita , Haryana Sofia Mubarika , Wirohadidjojo Yohanes Widodo , Arfian Nur
Published: December 2023

BACKGROUND: Ultraviolet B (UVB) induces skin photoaging by reducing collagen deposition via impairment of the TGF-β/Smad signaling pathway. Achatina fulica mucus (AFM) is a native medicine acting as vehicle of anti-aging ingredients. The present investigation examined the effect of AFM on UVB-induced fibroblast photoaging by assessing TGF-β, Smad3, and Smad7 mRNA expressions.METHODS: AFM was extracted from A. fulica using electrical shock and freeze-dried into a powder. Normal human dermal fibroblast (NHDF) cultures were irradiated with/without 100 mJ/cm2 UVB and treated with/without 10% platelet-rich plasma or different concentrations of AFM: 3.9 μg/mL in AF3 group; 15.625 μg/mL in AF15 group, and 62.5 μg/mL in AF62 group. The mRNA expressions of TGF-β, Smad3, and Smad7 in NHDF were evaluated by quantitative polymerase chain reaction.RESULTS: TGF-β mRNA expressions in the AF3 (0.85±0.01), AF15 (0.94±0.02) and AF62 (1.64±0.03) groups were significantly higher (p<0.05) compared with that in the UVB group (0.55±0.04). Moreover, Smad3 expressions in the AF3 (1.42±0.25), AF15 (1.89±0.13), and AF62 (2.50±0.31) groups were significantly higher (p<0.05) compared with that in the UVB group (0.57±0.08). Furthermore, Smad7 expressions in the AF3 (1.57±0.18), AF15 (0.87±0.03), and AF62 (0.25±0.09) groups were significantly lower (p<0.05) than that in the UVB group (2.57±0.06).CONCLUSION: AFM ameliorates UVB-induced fibroblast photoaging by upregulating the TGF-β/Smad3 expressions and downregulating Smad7 expression.KEYWORDS: Achatina fulica, TGF-β, Smad, collagen, UVB, fibroblast, photoaging
El principio lex specialis: una explicación crítica
Authors: Zorzetto Silvia
Published: December 2023

El principio lex specialis, según el cual las normas especiales se apartan de las normas generales, pertenece al núcleo de la tradición jurídica occidental. A los ojos de los juristas y filósofos del derecho, este principio tendría un sentido simple y claro, y sería un criterio para resolver las antinomias normativas. Este punto de vista general resulta insatisfactorio en muchos aspectos. Este artículo aborda tres tópicos generales que suelen quedar olvidados en la literatura. En primer lugar, se propone ilustrar la especialidad jurídica como una relación de género a especie entre conceptos jurídicos. En segundo lugar, se propone exa­minar el fenómeno de las normas generales y especiales no solo cuando sean conflictivas y generen antinomias total-parciales, sino principalmente cuando se trate de normas redundantes. En tercer lugar, y finalmente, se entiende que arroja luz sobre la divergencia entre normas especiales y generales en el contexto de la justificación jurídica.
Screening the Older for Abuse
Authors: Sjeničić Marta
Published: December 2023

Many countries are developing instruments to help prevent and recognize violence against the older. In the area of older abuse and its consequences, different screening methods have been developed and adapted to the country in which they are applied. Professionals are often not trained to detect signs of abuse, much less screen for the same, and therefore need continuous training in geriatrics and geriatric medicine. In order to draw attention to the older in the near future, specific measures should be prescribed not only within the framework of current legal regulations and bylaws, but also through guidelines, guides and other professional documents (soft-law), to be taken by state bodies, non-governmental organizations and other actors, for the purpose of screening violence, prevention of violence against the older, treatment of the older who have been subjected to violence and measures against its perpetrators, including forensics in cases of violence against the older. Instruments for organized screening for violence should be introduced in all sectors, but especially in the health and social care sectors, because primary health care and social work centers, in fact, are the gateway to the health and social system and make initial contact with service users, including the older.
Polypous rhinosinusitis: possibilities of anti-inflammatory therapy
Authors:   Vladimirsky Moscow Regional Research Clinical Institute, Moscow, 129110, Russia, Savlevich E. L. , Esakova N. V. ,   Academician Veltishchev Research Clinical Institute of Pediatrics and Pediatric Surgery,  Pirogov Russian National Research Medical University, Moscow, 125412, Russia, Egorov V. I. ,   Vladimirsky Moscow Regional Research Clinical Institute, Moscow, 129110, Russia
Published: December 2023

Current treatments for polypous rhinosinusitis (PRS) relieve symptoms but do not eliminate recurrence rates, highlighting research relevance, molecular targets, inflammation, and nasal mucosal function. Patients and methods. Formed 2 groups of patients (main (n = 44) and comparison (n = 20)) diagnosed with PRS. Patients of the main group were additionally prescribed the anti-inflammatory oral drug "Reglisam" for 90 days in the treatment regimen. In dynamics, the groups underwent endoscopy of the nasal cavity, scoring by VAS (from 0 to 3 points) of complaints and local symptoms of inflammation. Results. By the 45th day, in patients of the main group, the severity of sneezing, coughing, headache/facial pain was lower by 77, 56 and 87%, respectively, relative to the comparison group (p < 0.05), differences in the severity of symptoms of nasal congestion, discharge, postnasal drip was 24–34% (p < 0.05). By the 90th day in the main group, sneezing, headache/facial pain, and cough were completely stopped, in the comparison group, the symptoms persisted. In the main group, the degree of nasal congestion and nasal discharge were minimal, postnasal drip – 60% lower relative to comparison (p < 0.05). The proportion of patients in the main group with complaints of postnasal drip and nasal discharge by day 90 decreased by 41% and 32%, respectively (p < 0.05), sneezing, headache/facial pain and cough were absent. In the comparison group, the frequency of symptoms over time did not change significantly. According to endoscopy in the main group on the 90th day of treatment, mucous discharge was absent in 55% of patients (n = 24), edema was not recorded in 16% (n = 7). In the comparison group, mucous discharge was absent only in 30% (n = 6), edema persisted in all patients. The severity of mucous secretions and edema in patients of the main group was more than 2.5 times less than in the comparison group (p < 0.05). Conclusion. Treatment of PRS with the inclusion "Reglisam", in comparison with monotherapy with intranasal glucocorticosteroids, more effectively allows to stop swelling and inflammation in the nasal mucosa, improve mucociliary transport and drainage of the paranasal sinuses, normalize nasal breathing and improve the quality of life of patients.
Editorial
Authors: Geurs Karst , Ritsema van Eck Jan
Published: December 2023

That land-use and transport systems are interdependent and characterized by a two-way interaction is a well-known fact. The spatial configuration of activities influences the level and characteristics of transportation demand, and conversely, the location and quality of transportation infrastructure affects how activities are organized in space. Since the 1960s, several methodologies and models have been developed and used to examine the land-use and transport patterns and change. The research issues addressed using these models have, since the 1990s, been broadened to include sustainability impacts in transport policy, thereby strongly increasing modelling demands and raising several research challenges. This was the theme of a special session on ‘Land Use Transport Interaction Modelling and Sustainability’, as part of the international conference ‘Framing Land Use Dynamics’ held in April 2003 at Utrecht University (UU) in the Netherlands. The conference was organised as part of the Utrecht University’s multidisciplinary research programme, ‘Networks in the Delta’, aimed at developing a theoretical and methodological framework for understanding and modelling the complex interactions between socio-economic and environmental systems (see website Networks in the Delta (2004) for a full description). The papers included in this special issue of the European Journal of Transport and Infrastructure Research were presented at the conference under the theme, ‘Infrastructure, mobility and land-use planning’, focusing on transportation and land-use dynamics. Papers describe experiences with land-use and transport interaction models as impact assessment and policy appraisal tools, with contributions covering different local, regional and national spatial scales in Western European contexts, in particular, the United Kingdom, Germany and the Netherlands.