bluuebunny/crossref_metadata_2025 huggingface dataset:
O TEMPO DA CULTURA E AS PERMANÊNCIAS INDIVIDUAIS E COMUNITÁRIAS EM CONTEXTOS DA AMAZÔNIA SUL OCIDENTAL.
Authors: Santos Luciana Eliza dos , Castro Beatriz Magalhães de , Santos Alexandre Anselmo dos
Published: August 2022

O presente texto parte do olhar histórico para estabelecer comparativos e evocar a existência e permanência de práticas culturais de linguagem híbridas, presentes em regiões correspondentes à Amazônia sul ocidental, centralizando-se especificamente no Estado do Acre e nas fronteiras com países vizinhos como Bolívia e Peru. Estabelece uma breve reflexão acerca de bases para a história em perspectiva comparada e conectada como caminhos para reacomodar lacunas e apagamentos históricos. Aborda práticas culturais como os reisados do Japinin e o Boi Bumbá / Boi Carión, em consonância ao contexto rítmico e multicultural que envolve a configuração destas manifestações, historicamente presentes nas regiões mencionadas, para além das fronteiras imaginadas e constituídas nos percursos das comunidades.
Supplementary figures for "Direct Greenhouse Gas Emissions from a Pilot-Scale Aquaponics System"
Authors: Higgins Brendan , Kalvakaalva Rohit , Smith Mollie
Published: August 2022

Figure S1. Fish feeding rates over the course of the GHG study period. There was an intensive campaign of Tilapia production from May through August of 2019, resulting in the higher feeding rate. Production tempo slowed starting in September of 2019 and all feeding stopped for approximately the coldest month of the year. 

Figure S2. Dissolved oxygen levels (A) and temperature (B) in the fish tank. The boxed area shows the 10 month period of time during the GHG study.
Supplementary tables for "Direct Greenhouse Gas Emissions from a Pilot-Scale Aquaponics System"
Authors: Higgins Brendan , Kalvakaalva Rohit , Smith Mollie
Published: August 2022

This set of tables shows key inputs to the Auburn University aquaponics system over the course of four seasons from 2019-2020.
Korean Medicine Treatment for Managing Complex Regional Pain Syndrome: Case Report
Authors: Park Ji-won , Jeong Myung-In , Jeong Wu-Jin , Hong Hae-Won , Koo Ji-eun , Choi Sung-won , Kyung Da-hyun
Published: August 2022

A 53-year-old male who had received surgery on his right ankle joint 10 years previously was diagnosed with Complex Regional Pain Syndrome the following year. Despite various treatments (sympathetic nerve-block medication, pain relievers, corticosteroids, nerve blocks, and transcutaneous electrical nerve stimulation) over the years there was no improvement in his symptoms. Recently the patient was admitted to a Korean medicine hospital where he received treatment (acupuncture, pharmacopuncture, and herbal treatment) and his symptoms gradually showed improvement. The patient was concurrently on psychiatric medicine, antihistamine medication, and opioids for pain (when necessary). A decrease in numeric rating scale, Oswestry disability index scores, and an increase in the Korean version of the 5-level EuroQol-5 dimension score showed symptom improvement within 36 days. This study suggests complex Korean medicine treatment for Complex Regional Pain Syndrome may result in a reduction in pain and improved quality of life.
Effectiveness of Electroacupuncture in Patients with Chronic Fatigue Syndrome: A Systematic Review and Meta-analysis
Authors: Yang Jaewoo , Shin Donghoon , Oh Jihoon , Lim Jinwoong
Published: August 2022

This review evaluated the efficacy of electroacupuncture (EA) for chronic fatigue syndrome. Randomized controlled trials (RCTs) using EA as an intervention for patients with chronic fatigue syndrome were identified in 6 databases (PUBMED, EMBASE, CNKI, J-STAGE, KMBASE, OASIS). Fatigue indicators were used as the primary outcome measures. The quality-of-life index, efficiency rate, and level of pain were used as secondary outcome measures. There were 408 patients from seven RCTs included in this study. Meta-analysis showed that EA was significantly associated with fatigue relief compared with the control group (n = 141 SMD = -1.55, 95% CI: -2.58 - -0.52, p = 0.003, I² = 92%). In addition, EA had a statistically significant improvement in quality of life compared with the control group (n = 176, SMD = -2.29, 95% CI: -3.68 - -0.90, p = 0.001, I² = 96%). One study reported ten cases of bleeding, however, no serious adverse events were reported in any of the included studies. This review determined that EA may have a greater clinical effect than the control group for fatigue relief and improved quality of life. However, there were several risks of bias identified. Not all of the RCTs accurately reported the research method, all studies were conducted in 1 country (China), and the number of studies included were small.
Analysis of Research Trends in Korean Medicine Treatment for Guillain-Barre Syndrome in Korea
Authors: Jang Hyun Jin , Kim So Jeong , Kim Min Ju , Choi Hyeon Kyu , Lee Young Rok , Cha Hyun Ji , Jeong Jeong Kyo , Jeon Ju Hyun , Kim Young Il
Published: August 2022

This review aimed to analyze Korean medicine treatment (KMT) methods used for Guillain-Barre syndrome (GBS) in studies from January 1, 2010, to December 21, 2021. Five online databases (KISS, SCIENCEON, DBpia, RISS, KMbase) were searched for GBS-related studies. A total of 14 case reports were selected. Various treatment methods for GBS such as acupuncture, herbal medicine, moxibustion, and cupping have been reported, and some included Western medication. Herbal medicine and acupuncture were the most frequently used treatment methods. The most common prescription for GBS was Shipjeondaebotang Gami, the most common herb used was Glycyrrhizae radix et rhizome, and the most common acupoints were ST36, LI11, TE5, and LI4. In moxibustion treatment for GBS, CV4 was commonly used, and in cupping treatment the low back and back-shu points and were mostly used. Further studies on Korean medicine treatment of GBS are necessary for standardization of treatment.
“O CONTO DA AIA” EM APROXIMAÇÃO COM O CENÁRIO POLÍTICO BRASILEIRO
Authors: Sousa Sméra Larissa
Published: August 2022

O presente ensaio faz uma comparação entre a distopia “O Conto da Aia”, de Margaret Atwood, e o cenário político brasileiro na atualidade, buscando os pontos de convergência entre estes, com o intuito de demonstrar o quanto o governo bolsonarista se assemelha ao cenário distópico inconcebível do livro de Atwood. Observa-se as influências religiosas e a ausência de autonomia feminina, com as permanentes ameaças de retirada de direitos, principalmente das mulheres, como pontos em comum. Concluiu-se que existem, de fato, equivalências significativas entre a obra de Margaret Atwood e o atual contexto político brasileiro, com retrocessos sociais e políticos.
A REGULAMENTAÇÃO DA TELEMEDICINA NO BRASIL PELA RESOLUÇÃO 1.643/2002 DO CFM NO CONTEXTO DA PANDEMIA POR CORONAVÍRUS NO ANO DE 2020
Authors: Assis Layne Clara Costa
Published: August 2022

O presente artigo visa instituir de forma breve as bases para o implemento da telemedicina no Brasil no contexto da pandemia por coronavírus no ano de 2020. Para tanto, além de contextualizar historicamente o percurso da telemedicina no Brasil, busca compreender possíveis formas de teleatendimento através da internet, reconhecendo avanços tecnológicos empreendidos no sistema de saúde do primeiro epicentro da pandemia, a China.
POR UM DIREITO À CIDADE INCLUSIVO: O LUGAR DAS MINORIAS NO ESTATUTO E NAS CIDADES
Authors: Carvalho dos Santos Jader Vinicius
Published: August 2022

Contemporaneamente, à medida que as sociedades têm se tornado mais complexas e também mais urbanas, o debate acerca do Direito à Cidade tem sobrelevado-se, gradualmente, a um patamar de absoluta importância para a construção de um projeto de futuro para a humanidade. Adjunto a isso, o século XXI trouxe consigo também a crescente evidenciação da problemática das minorias, que tem lutado cada vez mais por espaço, voz, reconhecimento e respeito. Assim sendo, da interseção necessária entre essas duas temáticas profusas é que se trata o presente artigo, cujo objetivo principal é discutir as possibilidades emancipatórias da práxis social das minorias na conquista dos seus direitos, principalmente no que concerne o Direito à Cidade e a inclusão democrática dos sujeitos geossimbolicamente marginalizados na estrutura urbana e na esfera pública. A metodologia utilizada foi a pesquisa bibliográfica e a articulação teórico-conceitual do arcabouço interdisciplinar do Direito, da Filosofia e da Sociologia. Ao final do trabalho, concluiu-se que, embora negligenciado nos principais debates políticos atuais, o Direito à Cidade consiste em uma peça-chave na luta pela efetivação dos Direitos Humanos, sem o qual, portanto, não é possível falar na construção genuína de uma sociedade mais justa, igualitária e inclusiva.
CRIMES CONTRA A HUMANIDADE: O CASO BOLSONARO NO TRIBUNAL PENAL INTERNACIONAL
Authors: Cavalcante Amanda Sales da Silva
Published: August 2022

O presente artigo tem o objetivo de situar o potencial caso Bolsonaro no Tribunal Penal Internacional (TPI), suficiente a entender a legitimidade dos pedidos de investigação e averiguar, de forma superficial, a crise enfrentada no momento por todo o globo, com o recorte do Brasil. A situação do país é frágil em aspectos variados – na saúde, na economia e na política - e tratar sobre o direito internacional como uma faceta jurídica proeminente e essencial dentro de uma conjuntura eminentemente global.
VIOLÊNCIA SEXUAL E PANDEMIA DO SARS-COV-2: O VÍRUS INVISÍVEL QUE ACOMETE CRIANÇAS E ADOLESCENTES
Authors: Matos Carla Souza , Públio Carlos Alberto Maciel
Published: August 2022

A pandemia mundial provocada pelo coronavírus SARS-COV-2 modificou a perspectiva de convivência social adotadas antes do período de crise, a medida de isolamento social embora fundamental a prevenção ampliou o estado de vulnerabilidade de crianças e adolescentes, gerando infinitas formas de abuso intrafamiliar e violências sexuais, que precedem, são criadas ou fortalecidas na quarentena. Apesar dos impactos diferenciados e interseccionais sobre a materialização dos direitos fundamentais das crianças e dos adolescentes, o enfrentamento da violência sexual que acomete crianças e adolescentes deve ser prioridade absoluta, a partir de políticas sociais efetivas organizadas pela rede de atendimento e pelo fortalecimento dos vínculos familiares e comunitários, sobretudo, em contexto de crise mundial em que os casos de abusos cometidos contra crianças e adolescentes apresenta crescimento significativo.Descritores: Direito da Criança e do Adolescente. Violência Sexual. Pandemia.
A MOLÉSTIA PERMANENTE: O CONSERVADORISMO NO CONGRESSO NACIONAL COMO OBSTÁCULO NA PROTEÇÃO DE MULHERES VÍTIMAS DE VIOLÊNCIA DE GÊNERO DURANTE A PANDEMIA DE COVID-19
Authors: Soares Caroline Silva , Souza Juliana Ferreira Ribeiro de
Published: August 2022

O presente artigo pretende analisar a atuação do Congresso Nacional diante do aumento da violência de gênero no âmbito doméstico durante a pandemia de COVID-19, no que tange aos obstáculos conservadores criados nas tentativas de garantir a proteção das mulheres vítimas de violência por meio do instrumento legal. Verificou-se que utilizando de notícias falsas e discursos puramente moralistas religiosos, parlamentares, em maioria da Frente Evangélica Parlamentar, criaram entraves para aprovação e votação de projetos de lei protetivos. Para isso, utilizou-se o levantamento bibliográfico, estudo de documentos legislativos e análise de dados, com o objetivo de evidenciar a grande capacidade de indução de voto e criação de obstáculos, fundamentados na moral religiosa, mesmo diante do contexto de ameaça à vida. Palavras-chave: COVID-19; violência de gênero; conservadorismo.
A PANDEMIA COVID-19 NAS FAVELAS BRASILEIRAS: AS ESTRATÉGIAS DE SOBREVIVÊNCIA ADOTADAS PELA POPULAÇÃO À LUZ DO DIREITO AUTOCONSTRUÍDO
Authors: Barreto Matos Fabiana dos Anjos , Enéas Iago de Oliveira
Published: August 2022

O presente artigo pretende discutir as estratégias de sobrevivência adotadas por moradores de algumas favelas brasileiras para enfrentamento da pandemia Covid -19, frente a situação desproporcional de exposição ao vírus a que estão submetidos e a  inércia do Estado no oferecimento de Políticas Públicas de saúde nesses locais. Ainda, destaca brevemente o processo de formação das favelas brasileiras, algumas leis federais que impactaram nas regras de ocupação do espaço urbano nesses locais, bem como a relevância do direito auto construído para instrumento de cidadania no contexto da Pandemia, e alerta para a necessidade de uma atuação estatal que englobe a proteção de  todos como sujeitos de direitos conforme firmado constitucionalmente.
AUTONOMIA DA VONTADE DA CRIANÇA ENQUANTO SUJEITO DA PESQUISA FRENTE À DECISÃO FAMILIAR
Authors: Abreu Kamila Assis
Published: August 2022

O trabalho possui como objetivo analisar o Princípio da Autonomia da Vontade da criança enquanto sujeito da pesquisa, confrontando-o com os conceitos de Heteronomia, Dirigismo Estatal, Double Standard e Decolonização para, então, enfrentar o embate que a bioética enfrenta atualmente entre a autonomia da criança e o poder familiar no processo decisório. As visões antagônicas de Kant e Levinas sobre o instituto da autonomia no direito privado foram o ponto inicial do trabalho, o qual perpassou por uma breve análise do sistema normativo das pesquisas com seres humanos, com destaque para as Resoluções do Conselho Nacional de Saúde e atuação dos Comitês de Éticas. O Brasil encontra-se atrasado no debate mundial e aplicação da maximização ponderada da proteção da autonomia em detrimento dos demais princípios e, consequentemente, obsoleto quanto ao sistema de incapacidades do Direito Civilista. Concluiu-se que os confrontos entre direitos e interesses relacionados ao tema devem ser tratados à luz do Princípio da Proporcionalidade, devendo permitir o afastamento do poder familiar e do paternalismo dos pesquisadores, na intenção de garantir a autonomia da criança no processo decisório sempre que necessário para a execução do Melhor Interesse da Criança. Utilizou-se a Revisão de Literatura como método qualitativo de pesquisa.
BIOMASSA DE SERAPILHEIRA EM CERRADOS DE UNIDADES DE CONSERVAÇÃO INVADIDAS POR Pinus oocarpa
Authors: Oliveira dos Santos Galdino Amanda
Published: August 2022

Pinnus oocarpa Schiede ex Schltdl. é uma espécie originária do México e da América Central (PERRY, 1991), em áreas de 700 a 2000 metros de altitude (KEMP, 1973).
Indução de fitoalexinas por isolados de Bacillus spp e Trichoderma spp
Authors: Serra Souza Nathanael
Published: August 2022

As fitoalexinas (phyton = planta; alexin = composto repelente) foram descobertas inicialmente no século IX, entretanto estudos sobre caracterização, sua síntese e respostas de defesa em plantas resistentes e suscetíveis a patógenos só começaram a serempublicados no século XX (VIVANCO et al., 2005).
Coherent Raman spectroscopy on hydrogen with in-situ generation, in-situ use, and in-situ referencing of the ultrabroadband excitation
Authors: Mazza Francesco , Stutvoet Aert , Castellanos Leonardo , Kliukin Dmitrii , Bohlin Alexis
Published: August 2022

Time-resolved spectroscopy can provide valuable insights in hydrogen chemistry, with applications ranging from fundamental physics to the use of hydrogen as a commercial fuel. This work represents the first-ever demonstration of in-situ femtosecond laser-induced filamentation to generate a compressed supercontinuum behind a thick optical window, and its in-situ use to perform femtosecond/picosecond coherent Raman spectroscopy (CRS) on molecular hydrogen (H2). The ultrabroadband coherent excitation of Raman active molecules in measurement scenarios within an enclosed space has been hindered thus far by the window material imparting temporal stretch to the pulse. We overcome this challenge and present the simultaneous single-shot detection of the rotational H2 and the non-resonant CRS spectra in a laminar H2/air diffusion flame. Implementing an in-situ referencing protocol, the non-resonant spectrum measures the spectral phase of the supercontinuum pulse and maps the efficiency of the ultrabroadband coherent excitation achieved behind the window. This approach provides a straightforward path for the implementation of ultrabroadband H2 CRS in enclosed environment such as next-generation hydrogen combustors and reforming reactors.
Ultra-broadband and completely modulated absorption enhancement of monolayer graphene in a near-infrared region
Authors: Yan Zhendong , Kong Lingchen , Tang Chaojun , Deng Juan , Gu Ping , Chen Jing , Wang Xiangxian , Yi Zao , Zhu Mingwei
Published: August 2022

Achieving ultra-broadband and completely modulated absorption enhancement of monolayer graphene in near-infrared region is practically important to design graphene-based optoelectronic devices, however, which remains a challenge. In this work, by spectrally designing multiple magnetic plasmon resonance modes in metamaterials to be adjacent to each other, near-infrared light absorption in monolayer graphene is greatly improved to have an averaged absorption efficiency exceeding 50% in a very broad absorption bandwidth of about 800 nm. Moreover, by exerting an external bias voltage on graphene to change Fermi energy of graphene, the ultra-broadband absorption enhancement of monolayer graphene exhibits an excellent tunability, which has a nearly 100% modulation depth and an electrical switching property. This work is promising for applications in near-infrared photodetectors, amplitude modulators of electromagnetic waves, etc.
Strong and tunable absorption in coupled nanoparticle–cavity systems for plasmonically enhanced hot electron devices
Authors: Zhao Shenyou , Fusco Zelio , Beck Fiona J.
Published: August 2022

Designing plasmonic systems with tailored resonances based on
ultra-small metal nanoparticles (NPs) is fundamental for functional
hot electron devices. Here, a coupled NP array–optical cavity system
is demonstrated to enhance and control the absorption in small NPs. We
show that the interaction between cavity modes and resonances of fully
embedded NPs leads to a variety of optical behavior. Analytical and
numerical models provide a conceptual understanding of the coupling
mechanism, highlighting the role of NP density. In the strong-coupling
regime, strong and tunable absorption resonances are achieved by a
facile variation of the cavity length, while modification of NP
positions allows us to excite or avoid peak splitting in the
absorption spectra. Furthermore, hybridizing NP–cavity modes achieves
narrow-linewidth resonances, translating to a four-fold increase in
the quality factor compared to isolated NP arrays. This work provides
prescriptive guidelines for the design of efficient plasmonically
enhanced hot electron devices.
Molecular and spatial epidemiology of HCV among people who inject drugs in Boston, Massachusetts
Authors: Stopka Thomas J. , Yaghi Omar , Li Min , Paintsil Elijah , Chui Kenneth , Landy David , Heimer Robert
Published: August 2022

Integration of genetic, social network, and spatial data has the potential to improve understanding of transmission dynamics in established HCV epidemics. Sequence data were analyzed from 63 viremic people who inject drugs recruited in the Boston area through chain referral or time-location sampling. HCV subtype 1a was most prevalent (57.1%), followed by subtype 3a (33.9%). The phylogenetic distances between sequences were no shorter comparing individuals within versus across networks, nor by location or time of first injection. Social and spatial networks, while interesting, may be too ephemeral to inform transmission dynamics when the date and location of infection are indeterminate.
High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses
Authors: Sims Joshua J. , Lian Sharon , Meggersee Rosemary L. , Kasimsetty Aradhana , Wilson James M.
Published: August 2022

The viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly its cell-binding spike protein gene, has undergone rapid evolution during the coronavirus disease 2019 (COVID-19) pandemic. Variants including Omicron BA.1 and Omicron BA.2 now seriously threaten the efficacy of therapeutic monoclonal antibodies and vaccines that target the spike protein. Viral evolution over a much longer timescale has generated a wide range of genetically distinct sarbecoviruses in animal populations, including the pandemic viruses SARS-CoV-2 and SARS-CoV-1. The genetic diversity and widespread zoonotic potential of this group complicates current attempts to develop drugs in preparation for the next sarbecovirus pandemic. Receptor-based decoy inhibitors can target a wide range of viral strains with a common receptor and may have intrinsic resistance to escape mutant generation and antigenic drift. We previously generated an affinity-matured decoy inhibitor based on the receptor target of the SARS-CoV-2 spike protein, angiotensin-converting enzyme 2 (ACE2), and deployed it in a recombinant adeno-associated virus vector (rAAV) for intranasal delivery and passive prophylaxis against COVID-19. Here, we demonstrate the exceptional binding and neutralizing potency of this ACE2 decoy against SARS-CoV-2 variants including Omicron BA.1 and Omicron BA.2. Tight decoy binding tracks with human ACE2 binding of viral spike receptor-binding domains across diverse clades of coronaviruses. Furthermore, in a coronavirus that cannot bind human ACE2, a variant that acquired human ACE2 binding was bound by the decoy with nanomolar affinity. Considering these results, we discuss a strategy of decoy-based treatment and passive protection to mitigate the ongoing COVID-19 pandemic and future airway virus threats.
Optimal location of logistics distribution centres with swarm intelligent clustering algorithms
Authors: Lin Tsung-Xian , Wu Zhong-huan , Pan Wen-Tsao
Published: August 2022

A clustering algorithm is a solution for grouping a set of objects and for distribution centre location problems. But the common K-means clustering algorithm may give local optimal solutions. Swarm intelligent algorithms simulate the social behaviours of animals and avoid local optimal solutions. We employ three swarm intelligent algorithms to avoid these solutions. We propose a new algorithm for the clustering problem, the fruit-fly optimization K-means algorithm (FOA K-means). We designed a distribution centre location problem and three clustering indicators to evaluate the performance of algorithms. We compare the algorithms of K-means with the ant colony optimization algorithm (ACO K-means), particle swarm optimization algorithm (PSO K-means), and fruit-fly optimization algorithm. We find K-Means modified by the fruit-fly optimization algorithm (FOA K-means) has the best performance on convergence speed and three clustering indicators, compactness, separation, and integration. Thus, we can apply FOA K-means to improve the distribution centre location solution and the efficiency for distribution in the future.
Mechanism study of the impact of Escherichia coli on coal flotation
Authors: Li Jianbo , Wang Xizhuo , Meng Delong , Xia Ling , Song Shaoxian , Arauz Lara Bernardo José Luis
Published: August 2022

Escherichia coli as water-borne bacteria exists in the recirculation water of coal flotation and affects the recovery of coal flotation. In order to study the effect of Escherichia coli on coal flotation, we changed the concentration of Escherichia coli and pH in the coal flotation system and found that Escherichia coli had an adverse effect on coal flotation. The concentration of Escherichia coli was negatively correlated with the recovery of coal. When the concentration of Escherichia coli reached 5.0 × 109 cells/ml, the recovery of coal flotation was 50.25%, and the change of pH basically did not affect the adverse effect of Escherichia coli on coal flotation. The mechanism was studied through Zeta potential, Fourier transform infrared spectroscopy, Scanning electron microscopy and Contact angle measurements. The results revealed that Escherichia coli could be adsorbed to the coal surface by hydrogen bonding, which changed the hydrophobicity of the coal surface and then reduced the recovery of coal flotation.
Subtractive genomics profiling for potential drug targets identification against Moraxella catarrhalis
Authors: Ashraf Bilal , Atiq Nimrah , Khan Kanwal , Wadood Abdul , Uddin Reaz
Published: August 2022

Moraxella catarrhalis (M.catarrhalis) is a gram-negative bacterium, responsible for major respiratory tract and middle ear infection in infants and adults. The recent emergence of the antibiotic resistanceM.catarrhalisdemands the prioritization of an effective drug target as a top priority. Fortunately, the failure of new drugs and host toxicity associated with traditional drug development approaches can be avoided by using anin silicosubtractive genomics approach. In the current study, the advancedin silicogenome subtraction approach was applied to identify potential and pathogen-specific drug targets againstM.catarrhalis. We applied a series of subtraction methods from the whole genome of pathogen based on certain steps i.e. paralogous protein that have extensive homology with humans, essential, drug like, non-virulent, and resistant proteins. Only 38 potent drug targets were identified in this study. Eventually, one protein was identified as a potential new drug target and forwarded to the structure-based studies i.e. histidine kinase (UniProt ID: D5VAF6). Furthermore, virtual screening of 2000 compounds from the ZINC database was performed against the histidine kinase that resulted in the shortlisting of three compounds as the potential therapeutic candidates based on their binding energies and the properties exhibited using ADMET analysis. The identified protein gives a platform for the discovery of a lead drug candidate that may inhibit it and may help to eradicate the otitis media caused by drug-resistantM.catarrhalis. Nevertheless, the current study helped in creating a pipeline for drug target identification that may assist wet-lab research in the future.
Association between pregnancy intention and psychological distress among women exposed to different levels of restrictions during the COVID-19 pandemic in Australia
Authors: Schoenaker Danielle A. J. M. , Bennett Christie , Grieger Jessica A. , Harrison Cheryce L. , Hill Briony , Enticott Joanne , Moran Lisa J. , Teede Helena J. , O’Reilly Sharleen L. , Lim Siew
Published: August 2022

Background

The COVID-19 pandemic has had a negative impact on the mental health of people globally. Significant concerns about health and access to services among women of reproductive age considering pregnancy may cause psychological distress, and in turn increase health risks during and after pregnancy for mothers and offspring.

Objectives

To examine the association between pregnancy intention and psychological distress during the COVID-19 pandemic in Australia, and explore if this association differed based on local viral transmission rates and corresponding levels of pandemic restrictions.

Methods

A nationwide online survey was completed by 849 non-pregnant women aged 18–50 years between 15 October and 7 November 2020. Women were asked about their intention to become pregnant, and psychological distress was assessed using the Kessler Psychological Distress Scale (K10). Multivariable regression analysis examined associations between pregnancy intention and psychological distress. An interaction term was added to the model to examine differences in associations by level of viral transmission rates and lockdown restrictions which was determined based on postcode.

Results

Pregnancy intention was not associated with experiencing (very) high psychological distress in the overall study population (odds ratio (OR) 1.42, 95% CI 0.94, 2.11). The interaction term (p = 0.09) suggested potential differences by level of restrictions and viral transmission rates. In stratified analysis among women living in a location with strict lockdown restrictions and high viral transmission rates leading up to and during the study, those planning to become pregnant were more likely to experience (very) high psychological distress (OR 3.39, 2.04, 5.65) compared with women not planning to become pregnant. Pregnancy intention was not associated with psychological distress among women exposed to lower levels of pandemic restrictions and viral transmission rates (OR 1.17, 0.74, 1.85).

Conclusions

Our findings highlight the need to identify and support women planning pregnancy during a public health crisis to mitigate potential short- and long-term intergenerational negative health outcomes associated with psychological distress.
Mild hypothermia during cardiopulmonary bypass assisted CABG is associated with improved short- and long-term survival, a 18-year cohort study
Authors: Hendriks K. D. W. , Castela Forte J. N. , Kok W. F. , Mungroop H. E. , Bouma H. R. , Scheeren T. W. L. , Mariani M. , Henning R. H. , Epema A. H.
Published: August 2022

Data substantiating the optimal patient body temperature during cooling procedures in cardiac operations are currently unavailable. To explore the optimal temperature strategy, we examined the association between temperature management and survival among patients during cardiopulmonary bypass assisted coronary artery bypass grafting (CABG) procedures on 30-days and 5-year postoperative survival. Adult patients (n = 5,672, 23.6% female and mean (SD) age of 66 (10) years) operated between 1997 and 2015 were included, with continuous measured intraoperative nasopharyngeal temperatures. The association between mortality and patient characteristics, laboratory parameters, the lowest intraoperative plateau temperature and intraoperative cooling/rewarming rates were examined by multivariate Cox regression analysis. Machine learning-based cluster analysis was used to identify patient subgroups based on pre-cooling parameters and explore whether specific subgroups benefitted from a particular temperature management. Mild hypothermia (32–35°C) was independently associated with improved 30-days and 5-year survival compared to patients in other temperature categories regardless of operation year. 30 days and 5-year survival were 98% and 88% in the mild hypothermia group, whereas it amounted 93% and 80% in the severe hypothermia (<30°C). Normothermia (35–37°C) showed the lowest survival after 30 days and 5 years amounting 93% and 72%, respectively. Cluster analysis identified 8 distinct patient subgroups principally defined by gender, age, kidney function and weight. The full cohort and all patient subgroups displayed the highest survival at a temperature of 32°C. Given these associations, further prospective randomized controlled trials are needed to ascertain optimal patient temperatures during CPB.
Experiences of redeployed healthcare workers in the fight against COVID-19 in China: A qualitative study
Authors: Li Houshen , Cui Yifan , Efstathiou Nikolaos , Li Bo , Guo Ping
Published: August 2022

Introduction

Public health responses were triggered while COVID-19 was spreading. China redeployed healthcare workers to serve the most vulnerable populations and communities in the initial epicentre—Wuhan. However, it is not known how redeployment processes impacted on healthcare workers in a pandemic crisis.

Aims

To explore the experiences and needs of frontline healthcare workers who were redeployed to care for COVID-19 patients in Wuhan, China, and understand the long-term impacts of the redeployment experience on their work and life.

Methods

A qualitative study was conducted with redeployed healthcare workers using semi-structured interviews and thematic analysis. This study is reported in accordance with the consolidated criteria for reporting qualitative research (COREQ) guidelines.

Findings

A total of 20 redeployed healthcare workers (13 nurses and seven physicians) participated, and four themes were generated: (1) Initial feelings and emotions of redeployment—Participants experienced worries and concerns, a sense of isolation and loneliness on their arrival to the epicentre. (2) ‘It is like a war zone’—Healthcare workers faced a range of risks and challenges of caring for COVID-19 patients in Wuhan in the context of resource strain. (3) Uncertainty and coping strategies in patient care—Despite the hardships experienced, participants continued to deliver high-quality patient care including psychological care and palliative care, good communication and building mutual trusting relationships. (4) Reflection and far-reaching impacts of caring for COVID-19 patients—Participants felt motivated and encouraged as efforts were recognised by the government and wider society.

Conclusions

Redeployed healthcare workers shared their unique needs and experiences of coping with redeployment and challenges they faced in the context of resource strain, which has significant implications for policy and future practice. The reality of a pandemic may reduce healthcare workers’ willingness to work due to various reasons including inadequate preparedness of facilities and workplace safety. It is important to support frontline healthcare workers in order to maintain an adequate healthcare workforce in pandemic crises. Continuously evolving pandemic circumstances and uncertainty highlight the importance of an organized national pandemic response plan for subsequent waves of COVID-19 and future pandemics.
Modeling the spread of COVID-19 as a consequence of undocumented immigration toward the reduction of daily hospitalization: Case reports from Thailand
Authors: Intarapanya Tanatorn , Suratanee Apichat , Pattaradilokrat Sittiporn , Plaimas Kitiporn
Published: August 2022

At present, a large number of people worldwide have been infected by coronavirus 2019 (COVID-19). When the outbreak of the COVID-19 pandemic begins in a country, its impact is disastrous to both the country and its neighbors. In early 2020, the spread of COVID-19 was associated with global aviation. More recently, COVID-19 infections due to illegal or undocumented immigration have played a significant role in spreading the disease in Southeast Asia countries. Therefore, the spread of COVID-19 of all countries’ border should be curbed. Many countries closed their borders to all nations, causing an unprecedented decline in global travel, especially cross-border travel. This restriction affects social and economic trade-offs. Therefore, immigration policies are essential to control the COVID-19 pandemic. To understand and simulate the spread of the disease under different immigration conditions, we developed a novel mathematical model called the Legal immigration and Undocumented immigration from natural borders for Susceptible-Infected-Hospitalized and Recovered people (LUSIHR). The purpose of the model was to simulate the number of infected people under various policies, including uncontrolled, fully controlled, and partially controlled countries. The infection rate was parameterized using the collected data from the Department of Disease Control, Ministry of Public Health, Thailand. We demonstrated that the model possesses nonnegative solutions for favorable initial conditions. The analysis of numerical experiments showed that we could control the virus spread and maintain the number of infected people by increasing the control rate of undocumented immigration across the unprotected natural borders. Next, the obtained parameters were used to visualize the effect of the control rate on immigration at the natural border. Overall, the model was well-suited to explaining and building the simulation. The parameters were used to simulate the trends in the number of people infected from COVID-19.
Beyond the ‘terrors of performativity’: dichotomies, identities and escaping the panopticon
Authors: Goodley Claire , Perryman Jane
Published: August 2022

This article examines the influence of Stephen Ball’s work through the eyes of two former teachers turned academics who met through a mutual interest in his paper, ‘The teacher’s soul and the terrors of performativity’. We note our personal reactions to this particular paper and how Ball’s body of work has and continues to influence our thinking, careers and research. We note that his highly readable, provocative style of writing and passionate denunciation of league tables, inspections and the associated paraphernalia of control that appear central to neoliberal models of educational governance continue to prove useful in understanding global educational policy. This article also critically engages with the effects of such a seminal paper on the lived experience of the teaching profession. The first author argues that while Ball’s writing is useful to understand the pressures and struggles that teachers face, Ball’s use of Foucauldian notions such as ‘docile bodies’ and ‘subject-position’ can be seen to flatten out teachers, rendering them passive bystanders rather than agentic professionals. The second author revisits and recalls the influence of the paper on her early work, particularly on her concept of ‘panoptic performativity’, and the impact that the paper, and Stephen Ball’s work in general, continues to have on the wider field.
Cats Toxoplasmosis Control in Indonesia
Authors: Ramadhani Ageng Ilham , Yesica R , Wisesa IB GR
Published: August 2022

Toxoplasmosis is one of the parasitic diseases caused by Toxoplasma gondii (T. gondii). Toxoplasma gondii is usually found in cats’ faeces, raw vegetables, meats, grasses, and soil. The transmission of T. gondii happens vertically or horizontally. The standard diagnostic techniques of T. gondii detection are microscopic examination of cats faeces, PCR, and antibody detection. The drug of choice in cats toxoplasmosis is clindamycin antibiotic (doses: 10-12/kgBW), another treatment is the combination of sulfadiazine 120 mg/kgBW dan pirimetamin 1 mg/kgBW also can be given to reduce the oocyst shed. The prevention of T. gondii infection in cats is not giving raw meats and keeping the environment disinfected. The prevalence of cats toxoplasmosis in cats in Indonesia is influenced by multiple diagnostic techniques, sample total, geographical condition, and climate. The risk factor of toxoplasmosis infection in cats are stray cats, raw foods, and a hygienic environment. The purpose of this article is knowing the life cycle of T. gondii, clinical sign, pathogeneses, diagnostic method, risk factors, control, and the prevalence of cats toxoplasmosis in Indonesia in the last 50 years.
Antibiotic Resistance of the Campylobacter Isolates According to Their Species in Different Samples of Broiler Chicken in Many Regions
Authors: Hrustemović Elma , Čaklovica Faruk , Đeđibegović Jasmina , Smajlović Muhamed , Čaklovica K , Kudra Enida Članjak
Published: August 2022

Campylobacter jejuni and C. coli are contaminants of broiler skin, and in unauthorized numbers cause campylobacteriosis in consumers where symptoms range from gastrointestinal to life-threatening. The number of chicken bacteria and their genetic diversity depend on the growing conditions, and the presence of antibiotic resistance genes is the result of irrational use of antibiotics. The purpose of this paper is to point out the importance of reducing the contamination of Campylobacter spp. in broiler production as well as the importance of the rational use of antibiotics in the production of broilers with a contribution to the prevention of the spread of campylobacteriosis and antibiotic resistance. The incidence of campylobacteriosis can be prevented by the concept of Hazard Analysis Critical Control Point (HACCP) in broiler production and the use of probiotics as biological preservatives in broiler meat. The spread of antibiotic resistance genes can be reduced by prohibition of antibiotic use for   prophylaxis and only permitted for medication.
Literatura Infantil: o uso do Storyboard That bordando atividades
Authors: Teixeira Damares Reis , Dutra Alessandra , Oliveira Marilu Martens
Published: August 2022

Este artigo tem como foco o uso de um recurso tecnológico digital para planejamento de atividades avaliativas em aulas de Literatura. Trata-se, metodologicamente, de uma pesquisa quantitativa, de caráter descritivo, com participação de vinte docentes que atuavam na Educação Infantil. Partiu-se da seguinte questão problematizadora: qual a percepção dos professores de Literatura em relação ao uso do recurso digital Storyboard That, para o planejamento de atividades avaliativas? Objetivou-se discutir as especificidades do uso das tecnologias digitais no processo de ensino e aprendizagem, com ênfase no recurso digital supracitado. Os resultados apontaram que os participantes aprovaram o referido recurso, considerando-o uma boa opção para seu trabalho. Porém sentem-se inseguros em relação ao uso de tecnologias digitais, o que aponta para a necessidade de maior mobilização para a atualização dos envolvidos, nos processos educativos, no que tange às novas tecnologias digitais disponíveis, por meio de cursos de formação continuada.
In Silico Domain Structural Model Analysis of Coronavirus ORF1ab Polyprotein
Authors: Jameel Mohammed I. , Noori Rabar J. , Rasul Soma F.
Published: August 2022

The world today is battling with a coronavirus infection that is considered a global pandemic. Coronavirus infection is mainly attribute to the varying technique of the replication and release of different genomic components of the virus. The present study aims to establish the physical and chemical features, as well as the basic structural and functional properties of Coronavirus ORF1ab domain. A molecular approach was adopt in this study using the Swiss Model and Phyre2 server whereas the prediction of the active ligand binding sites was done using Phyre2. The analysis of the structure of the protein showed that it has good structural and heat stability, as well as better hydrophilic features and acidic in nature. Based on the Homology modeling, only two binding active sites were noted with catalytic function being mediated by Zn2+ as the metallic heterogeneous ligand for binding sites prediction. The proteins mostly exhibited helical secondary configurations. This study can help in predicting and understanding the role of this domain protein in active coronavirus infection.
An efficient recurrent neural network with ensemble classifier-based weighted model for disease prediction
Authors: Kesavan Tamilselvi , Krishnamoorthy Ramesh Kumar
Published: August 2022

Day-to-day lives are affected globally by the epidemic coronavirus 2019. With an increasing number of positive cases, India has now become a highly affected country. Chronic diseases affect individuals with no time identification and impose a huge disease burden on society. In this article, an Efficient Recurrent Neural Network with Ensemble Classifier (ERNN-EC) is built using VGG-16 and Alexnet with weighted model to predict disease and its level. The dataset is partitioned randomly into small subsets by utilizing mean-based splitting method. Various models of classifier create a homogeneous ensemble by utilizing an accuracy-based weighted aging classifier ensemble, which is a weighted model’s modification. Two state of art methods such as Graph Sequence Recurrent Neural Network and Hybrid Rough-Block-Based Neural Network are used for comparison with respect to some parameters such as accuracy, precision, recall, f1-score, and relative absolute error (RAE). As a result, it is found that the proposed ERNN-EC method accomplishes accuracy of 95.2%, precision of 91%, recall of 85%, F1-score of 83.4%, and RAE of 41.6%.
Molecular Markers of Mechanosensation in Glycinergic Neurons in the Avian Lumbosacral Spinal Cord
Authors: Stanchak Kathryn E. , Miller Kimberly E. , Lumsden Eric W. , Shikiar Devany , Davis Calvin , Brunton Bingni W. , Perkel David J.
Published: August 2022

Birds are exceptionally adept at controlling their body position. For example, they can coordinate rapid movements of their body while stabilizing their head. Intriguingly, this ability may rely in part on a mechanosensory organ in the avian lower spinal cord called the lumbosacral organ (LSO). However, molecular mechanotransduction mechanisms have not been identified in the avian spinal cord. Here, we report the presence of glycinergic neurons in the LSO that exhibit immunoreactivity for myosin7a and espin, molecules essential for function and maintenance of hair cells in the inner ear. Specifically, we find glycinergic cell bodies near the central canal and processes that extend laterally to the accessory lobes and spinal ligaments. These LSO neurons are reminiscent of glycinergic neurons in a recently-described lateral spinal proprioceptive organ in zebrafish that detects spinal bending. The avian LSO, however, is located inside a series of fused vertebrae called the synsacrum, which constrains spinal bending. We suggest the LSO may be a modification and elaboration of a preexisting mechanosensory spinal network in vertebrates. A mechanistic understanding of its function may be an important clue to understanding the evolution and development of avian locomotion.
Sex-specific association between urinary kisspeptin and pubertal development
Authors: Freitas Rafaella Sales de , França Thiago F A , Pompeia Sabine
Published: August 2022

Kisspeptins play a crucial role during pubertal development, but little is known about how their peripheral concentrations relate to sexual maturation. This is partly due to the lack of non-invasive, quick, and reliable peripheral kisspeptin measures, which limit widespread testing. Here, we investigated the relationship between kisspeptin concentrations measured from midstream urine samples with 2-h retention periods and developmental markers (age, self-reported pubertal status, and saliva concentrations of testosterone and DHEA sulphate ) in 209 typically developing 9- to 15-year-old males and females. As a result of the study, we found marked sex differences. Kisspeptin concentrations were similar between sexes until around 12 years of age, but, thereafter, kisspeptin concentrations in females did not change significantly, whereas, in males, there was a clear positive correlation with developmental measures. Our results replicate previous findings regarding kisspeptin concentration changes across the pubertal transition obtained from blood samples, suggesting that measuring these peptides in urine has the potential for exploring kisspeptins’ peripheral effects and their associations with pubertal status.
Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice
Authors: Lafferty Ryan A , McShane Laura M , Franklin Zara J , Flatt Peter R , O’Harte Finbarr P M , Irwin Nigel
Published: August 2022

Discerning modification to the amino acid sequence of native glucagon can generate specific glucagon receptor (GCGR) antagonists, that include desHis1Pro4Glu9-glucagon and the acylated form desHis1Pro4Glu9(Lys12PAL)-glucagon. In the current study, we have evaluated the metabolic benefits of once-daily injection of these peptide-based GCGR antagonists for 18 days in insulin-resistant high-fat-fed (HFF) mice with streptozotocin (STZ)-induced insulin deficiency, namely HFF-STZ mice. Administration of desHis1Pro4Glu9-glucagon moderately (P < 0.05) decreased STZ-induced elevations of food intake. Body weight was not different between groups of HFF-STZ mice and both treatment interventions delayed (P < 0.05) the onset of hyperglycaemia. The treatments reduced (P < 0.05–P < 0.001) circulating and pancreatic glucagon, whilst desHis1Pro4Glu9(Lys12PAL)-glucagon also substantially increased (P < 0.001) pancreatic insulin stores. Oral glucose tolerance was appreciably improved (P < 0.05) by both antagonists, despite the lack of augmentation of glucose-stimulated insulin release. Interestingly, positive effects on i.p. glucose tolerance were less obvious suggesting important beneficial effects on gut function. Metabolic benefits were accompanied by decreased (P < 0.05–P < 0.01) locomotor activity and increases (P < 0.001) in energy expenditure and respiratory exchange ratio in both treatment groups. In addition, desHis1Pro4Glu9-glucagon increased (P < 0.01–P < 0.001) O2 consumption and CO2 production. Together, these data provide further evidence that peptidic GCGR antagonists are effective treatment options for obesity-driven forms of diabetes, even when accompanied by insulin deficiency.