bluuebunny/crossref_metadata_2025 huggingface dataset:
Aquisição de linguagem: o envelope multimodal em uma criança autista
Authors: Oliveira Ádelly Kalyne da Silva , Fonte Renata Fonseca Lima da
Published: August 2023

Com foco na abordagem multimodal, perspectiva teórica que defende a matriz gesto-vocal como um sistema único de significação, objetivamos analisar a mescla entre olhar, vocalizações e gestos na produção de uma criança autista do sexo feminino. Especificamente, intencionamos identificar como os referidos elementos semióticos contribuem para a negociação de sentidos na interação e quais os papéis emitidos por esses componentes significativos. Nesse sentido, constatamos que a tríade semiótica de articulação entre gesto, produção vocal e olhar promove um lócus de enunciação para a criança autista e percebemos o quão necessário é considerar esses componentes, que constituem o envelope multimodal, no processo de aquisição linguística.
Revisitando o conceito de “contexto de produção” em duas obras do Interacionismo Sociodiscursivo
Authors: Santos Thiago Jorge Ferreira
Published: August 2023

Este artigo objetiva analisar as bases do conceito de “contexto de produção” na teoria do Interacionismo Sociodiscursivo (ISD) à luz dos marxistas e estudiosos da linguagem russos Valentin Volóchinov e Pável Medviédev, cotejando-o particularmente com a noção de “meio ideológico” proposta por eles no quadro da ciência das ideologias. Frequentemente, esses dois conceitos são abordados indiscriminadamente. Para isso, visitaremos duas obras do ISD, nas quais é apresentado o modelo de análise textual/discursiva da teoria, quais sejam, “O funcionamento dos discursos: um modelo psicológico e um método de análise” (1985) e “Atividade de linguagem, textos e discursos: por um interacionismo sociodiscursivo” (1997). Os resultados mostram que, na obra de 1997, diferentemente do livro de 1985, o conceito de “contexto de produção” no ISD é embasado na teoria do agir comunicativo de Habermas, filósofo revisionista de Marx, sobretudo do sentido político da “luta de classes” do marxismo, que é a base da concepção ideológica de Volóchinov e Medviédev.
Emergência do conector "fora que" no português
Authors: Lopes Monclar Guimarães
Published: August 2023

Este artigo tem como objetivo descrever a emergência do conector [fora que] no português, uma construção de valor aditivo empregada em contextos (supra)oracionais. Trata-se de uma investigação realizada em perspectiva diacrônica, com base em dados extraídos dos séculos XIX, XX e XXI. Como fundamentação teórica, recorremos aos pressupostos da Linguística Funcional Centrada no Uso (cf. CUNHA et al., 2013; ROSÁRIO; OLIVEIRA, 2016 etc.), com foco especial na perspectiva da construcionalização (TRAUGOTT; TROUSDALE, 2021 [2013]; TRAUGOTT, 2022), pensada para estudos em mudança linguística. Recorremos a duas bases de dados do Corpus do Português: o Histórico e o Now. Ao todo, foram analisadas 462 ocorrências, distribuídas nos diferentes séculos, por meio de uma metodologia quali-quantitativa. Os resultados apontam para a existência de um processo analógico para a emergência do conector [fora que], em que o elemento fora, na função de palavra denotativa de exclusão, teria sido recrutado pelo esquema [Xque]conect (cf. CEZARIO; SANTOS; SILVA, 2015).
Emergência e convencionalização da construção V LEVE (DAR, FAZER) + SN
Authors: Cunha Maria Angélica Furtado da
Published: August 2023

Sob a perspectiva teórica da Linguística Funcional Centrada no Uso, este trabalho investiga o surgimento e a convencionalização da construção VLEVE + SN com os verbos leves dar e fazer empregados em uma configuração triargumental. A análise utiliza dados de escrita coletados em corpora que registram o português do Brasil em uso do século XVII ao XXI. O estudo é predominantemente qualitativo, apoiando-se em suporte quantitativo para aferição de tendências. São analisados a ordenação dos argumentos dessa construção, os atributos do SN que acompanha o verbo leve, a preferência por determinados nomes nessa posição e a formação de chunks. Os resultados obtidos indicam que a posição que o SN ocupa na oração reflete o grau de fixação e de convencionalização da sequência VerboLEVE + SN, contribuindo para a constituição de chunks. Esses chunks desempenham funções discursivo-pragmáticas específicas nos textos em que são usados.
A microconstrução intensificadora [com força] no Português Brasileiro: uma análise em perspectiva construcional
Authors: Souza Edson Rosa Francisco de , Barbosa Letícia de Almeida
Published: August 2023

O objetivo deste artigo é analisar, com base nos estudos cognitivos-funcionais de Bybee (2016) e na abordagem construcional de Traugott e Trousdale (2013), a microconstrução intensificadora [com força], instanciada pelo subesquema construcional [[X] prep N]intensif no português brasileiro, que modifica tanto predicados verbais, como em [correr com força], quanto predicados adjetivais, como em [feio com força]. Para a análise dos dados, utilizamos as subamostras Histórico/Gênero e Web/Dialetos do Corpus do Português (DAVIES; FERREIRA, 2006), referentes aos séculos XIII-XXI. Em linhas gerais, verificamos que, ao longo da história e do processo de formação da microconstrução [com força] no português brasileiro, ela passou por mudanças morfossintáticas e semânticas que foram responsáveis pela veiculação de quatro valores semânticos distintos de funcionalidade: modo, instrumento, predicativo e intensidade, tendo a intensificação se originado a partir dos valores de modo e instrumento. Com base na análise dos dados do corpus, foi possível notar que o surgimento da expressão [com força] enquanto expressão intensificadora se dá a partir do século XIX.
Descrição diacrônica da expressão pronominal do argumento-sujeito no português brasileiro
Authors: Guerra Alessandra Regina
Published: August 2023

Este artigo apresenta dados diacrônicos sobre a opcionalidade entre expressão e não expressão pronominal do argumento-sujeito no português brasileiro. O quadro teórico é formado por uma articulação entre a Gramática Discursivo-Funcional e um conjunto de trabalhos funcionalistas que lidam com motivações comunicativas da estrutura das línguas, tais como, iconicidade e economia. Os dados são levantados a partir de um corpus especificamente constituído para a realização da pesquisa, formado por peças de teatro brasileiras. O período recoberto pela investigação se estende da primeira metade do século XIX ao início do século XXI. Como resultado, o trabalho (i) oferece dados quantitativos que, corroborando outras pesquisas, mostram e documentam detalhadamente o aumento diacrônico da opção por expressão pronominal, em oposição à não expressão, e (ii) disponibiliza ocorrências exemplificativas de ambas as opções, distribuídas por todo o período em análise.
Esquematicidade e produtividade na reconfiguração da rede de conectores condicionais
Authors: Oliveira Taisa Peres de , Clemente Camila Gabriele da Cruz
Published: August 2023

Neste artigo, propomos demonstrar como as mudanças na produtividade das microconstruções sancionadas por [VNão-Fin que]Cond afetam seu grau de esquematicidade e levam à reconfiguração da rede em um todo. Como resultado de mudanças diversas, o subesquema [VNão-Fin que]Cond sanciona, no século XIX, as microconstruções [supondo que]Cond, [considerando que]Cond, [dado que]Cond e [posto que]Cond. No entanto, no século XXI mudanças na produtividade afetam a configuração desse subesquema que parece perder algumas de suas microconstruções. Nossa análise mostra que o grau de generalização e a extensibilidade do esquema mais geral é constantemente alterada como resultado de mudanças na produtividade em níveis menos esquemáticos e mais específicos, provocando, assim, a reconfiguração de toda a rede. Para sustentar nosso estudo, utilizamos as bases teóricas da Abordagem Construcional da Mudança Linguística de autores como Traugott e Trousdale (2021), Hilpert (2021), Barðdal (2008) e Perek (2016). Os dados utilizados foram coletados em dois bancos de dados diacrônicos, o Córpus do Português (FERREIRA; DAVIES, 2006) e o Banco Informatizado de Textos do Programa para a História da Língua Portuguesa (BIT-PROHPOR/UFBA, 2002).
MOL Pakistan P&A Campaign Review - Lessons Learnt and Takeaways to Deliver Cost Effective P&A Projects
Authors: Ali Aslam , Khan Shahjahan , Anwar Muhammad Waseem , Saleem Ammar Bin , Talha Muhammad Shahzad
Published: August 2023

With the tremendous increase in Plug and Abandonment activities globally, Oil and Gas E&P Companies are opting strategic approach for P&A as per industry regulations and standards. Plug and abandonment of well having integrity issues, typically contributes to 15% - 25% of the cost of drilling exploration well. MOL Pakistan has recently performed an extensive P&A campaign where numerous challenges were encountered. Since, every well is unique, so are the challenges associated with it. This paper discusses the challenges encountered in the P&A of wells along with the methodology and approach to counter the same, optimization of subsequent operations, journey through technological transformation over time in P&A projects and delivering cost effective P&A projects. Most P&A jobs performed, involved restricted accessibility to the wellbore due to broken tubing and completion assemblies in depleted reservoirs with limited information about sand-face and reservoir pressures requiring complex well killing operation and managing/addressing sustained casing pressures (SCP) in multiple annuli.

To achieve excellence in P&A projects delivery and optimising time and cost, systematic methodology was adopted where special emphasis was made on in house expertise development, establishing combined task force with service providers involving their regional teams, discussing problems and lessons learnt with industry P&A experts and finding optimum tools and technology. Communication and reporting being a very important tool in the process, it was ensured that during execution of project, daily meeting, weekly operations forecast, and risk assessment meetings are conducted regularly between field and office operations team to discuss and optimize upcoming operations

As a result successful operations were performed in complex P&A wells involving: retrieval of broken completion strings, retrieval of casing strings based on URS/CBL-VDL recorded in double casing, optimising number of cement plugs while complying to industry standards and requirements; retrieval of casing slips from well head with casing cemented to surface, successfully performing 1st ever application of 13 3/8″ casing pilot milling from the surface in asia pacific to expose annulus and treat sustained casing pressures in multiple annulus. Consequently, Successful P&A projects were delivered with time and cost reduction up to 40% in 2021 as compared to the first P&A project in 2018 by utilizing rigorous lessons learning process implementation.
Journey of Hydraulic Frac Stimulation
Authors: Iqbal F. , Ahmed Q. , Ahmed R.
Published: August 2023

Hydraulic frac, over the last few decades has significantly changed conventional and unconventional resource portfolio. The modern advancement and effective customized use of the technology have done fortune to what was non-producible & non-recoverable hydrocarbon resource. Global industry wide learning curve of hydraulic frac is at a mature stage. However, local industry is still emerging in terms of large-scale application of hydraulic fracturing as stimulation technique.

The early attempts of fracturing in early 90's revealed significant operation challenges due to limited handle around the regional tectonics and after few attempts the formation was deemed to be un-frackable. As part of UEP innovative Technology deployment portfolio, the subject was revisited and through continuous improvement process, significant breakthrough in hydraulic frac technology has been realized.

The paper presents a summary of UEP journey in developing hydraulic frac technology over the years. It summarizes the challenges faced in designing/modelling, execution of treatments and their functional dependence on critical controls ranging from regional tectonic settings to rock/reservoir intrinsic properties. The case studies explain methodologies adopted to unleash tight gas potential, establish tight oil potential, resolve deliverability, and sand production challenges through successful deployment of hydraulic frac activity.

This breakthrough in technology deployment has created a line of sight to exploit and unlock significant contingent resources in UEPL portfolio. The organization is now ready to extend the appraisal activities to a full deployment stage.
Understanding Source of Produced Water with Varying Salinities in Oil and Gas Field of Eastern Potwar, A Case Study
Authors: Khanam Mehwish , Javed Waqar Ali , Nazeer Adeel , Daud Farrukh , Ashraf Zaid , Wahid Farhan , Ali Shahzad
Published: August 2023

X field is producing water along with hydrocarbon from Tobra, Khewra & Sakesar reservoirs. Hence, it is imperative to understand the source of this water and its entry into the wells to optimize the field's production and limit the water production within the available water handling and disposal constraints. Even though multiple wells have been drilled in the field to-date, depth of the free water level is still unknown in the Tobra and Khewra formations. Large uncertainty lies with the thickness of the transition zone across the reservoirs with permeabilities ranging from 4 to 10 md. Besides, capillary forces are likely to have some effect in the rise of water in the pore space leading to some water production. In context of the uncertainties associated with the water breakthrough time and predicting the trend of water cut, it is considered useful to investigate the source of water via the information on the salinities and ion analyses.

Four types of water have been produced from four types of reservoir rocks. Water ranges from fresh to brackish, and brackish to brine. Murree Formation is producing freshwater on surface; and hydrocarbon (HC) shows during drilling. Water production in Sakesar is high with relatively less salinity and high pressures. Surface Well Testing (SWT) data confirmed the water salinity of brine origin with varying composition. Sakesar formation's water salinity in X field ranges between 10,000 - 20,000 ppm is because of fresh water mixing with marine origin. However, nearby regional produced water salinity is 50,000 - 60,000 ppm from Sakesar. SWT data showed the production of high saline water in Tobra and Khewra reservoirs. However, salinity greater than 80,000 ppm is not associated with depositional environment of glacial sands (Tobra), and deltaic sands (Khewra); nor present in present day oceans and seas. Probably high saline water (brine) encroached in the formation from somewhere else.

Our research is based on the chemical testing of water samples collected during well testing campaigns. Data was analyzed to understand the origin of water in Potwar Plateau, X field and probable ranges of salinity in different depositional environment. This case study is focused on the source of water from underlying formations or through deep seated faults. Same will be confirmed by detailed evaluation of SWT data and water analyses. In this paper, water breakthrough will be discussed with varying salinities in different wells depending upon the faults in the vicinity.
Morphological and functional differences of monocyte derived dendritic cells in patients with acute coronary syndrome
Authors: Wang Zhenglong , Ke Changhao , Cheng Yuheng , He Yuanjie , Shi Bei
Published: August 2023

Objective To investigate the morphological and functional differences of monocyte derived dendritic cells in different types of ACS patients.
Methods The peripheral blood mononuclear cells (PBMC) were isolated and differentiated into mononuclear dendritic cells (moDC) which morphology was observed by electron microscope and its related molecules (CD11c, CD14, CD80, CD86, HHLA -DR) were identified by flow cytometry (FCM) and the expression levels of IL6, IL10 and IL12p70 were detected by ELISA in acute coronary syndrome patients with unstable angina (UA), non-ST elevation myocardial infarction (NST), ST elevation myocardial infarction (ST) and healthy control group (CON).
Results (1) FCM showed the moDC surface molecules CD11c and HLA-DR were highly expressed, while CD80 and CD86 were weakly expressed. (2) Electron microscopy showed the DC of UA, NST and ST groups had longer and more dense pseudopods than that of CON group. The expression levels of CD80 and HLA-DR in ST group and NST group were increased, while the expression levels of OVA were decreased compared with CON group and UA group,(p<0.05). (3) The levels of serum IL6 and IL12p70 in ST and NST groups were significantly higher than those in CON and UA groups (p<0.05), but there was no significant difference in the expression level of IL10 among the four groups.
ConclusionsThe morphology and function of moDC in patients with different types of ACS are different. In patients with acute myocardial infarction (AMI), moDC has stronger antigen presenting ability, pro-inflammatory secretion function and weaker phagocytosis ability compared with non-myocardial infarction patients
PHA Production from Molasses Using Mixed Microbial Cultures: Techno-Economic Feasibility AnalysisPHA Production from Molasses Using Mixed Microbial Cultures: Techno-Economic Feasibility Analysis
Authors: Shen Ming-Yan , Souvannasouk Vannasinh , Saipa Sasithorn , Chu Chen-Yeon , Tantranont‬ Nuttiya , sawatdeenarunat Chayanon
Published: August 2023

Today, about 4.8–12.7 million tons of fossil-based plastics have reached the oceans. Thus, this pollution has become a matter of significant concern globally. Polyhydroxyalcanoates (PHAs) are one of the promising biodegradable plastics that could replace conventional petroleum-based plastics and subsequently mitigate oceanic pollution. High organic wastewater has been examined as a potential substrate for lowering the manufacturing cost of PHAs. This study has found that for a project lifetime of 20 years, the cost of the PHA manufacturing process reached $994,143. The annual process operation cost was $159,711. The payback period was 6.79 years, and the internal return rate was 16%. However, if costs increased by 20%, the benefits decreased by 25%. Since price of PHAs is higher than that of conventional plastic, various supports from the government could potentially push PHAs to the market.
Statement of Novelty
This study successfully determines the techno-economic analysis of the PHA production to form high-strength waste using MMC as the microbial source. The sensitivity analysis of the system was also performed.
Real time Analysis of Virtual Reality Art Design Based on Immersive communication
Authors: Liu Liping
Published: August 2023

The traditional indoor virtual reality art design is quite different from the actual placement of items. Based on the perspective of immersive communication, this paper analyzes the specific ways of applying virtual reality technology in art design from the two dimensions of physiological immersion and psychological immersion, so as to analyze the process of Virtual Reality Art Design Based on Immersive communication. The Kinect device is used to collect the indoor spatial feature depth data. After repair and filtering, the processed data is converted into the data in the spatial coordinate system to build the geometric model of the spatial feature data. This paper analyzes the indoor virtual reality art design by using virtual reality technology. The experiment proves that the placement error of the indoor virtual reality artistic achievements is small.
Vascular ATGL-dependent lipolysis protects endothelial function against exogenous lipids overload; involvement of endogenous cPLA2–PGI2 pathway
Authors: Sternak Magdalena , Stojak Marta , Banasik Tomasz , Kij Agnieszka , Bar Anna , Pacia Marta Z , Wojnar-Lason Kamila , Chorazy Natalia , Mohaissen Tasnim , Marczyk Brygida , Czyzynska-Cichon Izabela , Mika Adriana , Chlopicki Stefan
Published: August 2023

Adipose triglyceride lipase (ATGL) is involved in lipolysis and displays detrimental pathophysiological role in cardio-metabolic diseases. However, the organo-protective effects of ATGL-induced lipolysis were also suggested. The aim of this work was to characterize the function of lipid droplets (LDs) and ATGL-induced lipolysis in the regulation of endothelial function. ATGL-dependent LDs hydrolysis and cytosolic phospholipase A2 (cPLA2)-derived eicosanoids production were studied in the aorta, endothelial and smooth muscle cells exposed to exogenous oleic acid (OA) or arachidonic acid (AA). Functional effects of ATGL-dependent lipolysis was studied in vitro in endothelial barrier integrity assay and in vivo in relation to postprandial endothelial dysfunction. The formation of LDs was invariably associated with elevated production of endogenous AA-derived prostacyclin (PGI2). In the presence of the inhibitor of ATGL or the inhibitor of cytosolic phospholipase A2,, production of eicosanoids was reduced, with concomitant increase in the number of LDs. OA administration impaired endothelial barrier integrity in vitro that was further impaired if OA was given together with atglistatin. In vivo, olive oil induced postprandial endothelial dysfunction that was significantly deteriorated by ATGL inhibition. In summary, vascular lipid droplets formation was associated with ATGL- and cPLA2-dependent PGI2 production from endogenous AA. The inhibition of ATGL resulted in an impairment of endothelial barrier function in vitro and deterioration of endothelial function upon exposure to olive oil in vivo. These results demonstrate that vascular ATGL-cPLA2-PGI2−dependent pathway activated by lipid overload and linked to LDs formation in endothelium and smooth muscle cells has a vasoprotective role and counterbalances detrimental vascular effects of lipid overload.
Predictive value of maternal serum placental growth factor levels for discordant fetal growth in twins: A retrospective cohort study
Authors: Li Shuai , Wu Kaiqi , Zhou Shaomin , Yin Binbin , Bai Xiaoxia , Zhu Bo
Published: August 2023

Background
Accurate prenatal recognition of discordant fetal growth in twins is critical for deciding suitable management strategies. We explored the predictive value of the level of maternal second-trimester placental growth factor (PLGF) as a novel indicator of discordant fetal growth.
Methods
A total of 860 women pregnant with twins were enrolled, including 168 women with monochorionic twins (31 cases of discordant fetal growth and 137 without) and 692 with dichorionic twins (79 cases of discordant fetal growth and 613 without). Maternal second-trimester PLGF concentrations were measured via immunofluorescence.
Results
Maternal second-trimester PLGF levels were significantly lower in women pregnant with twins who subsequently developed discordant fetal growth than in those who did not (monochorionic twin pregnancy: P < 0.001; dichorionic twin pregnancy: P < 0.001). A 3–4 fold difference in median PLGF concentrations was detected between the two groups with both monochorionic and dichorionic twin pregnancies. Maternal second-trimester PLGF levels were significantly correlated with birth weight differences (monochorionic twin pregnancy: r = − 0.331, P < 0.001; dichorionic twin pregnancy: r = − 0.234, P < 0.001). A receiver operating characteristic curve was used to evaluate the predictive efficiency. In monochorionic twin pregnancies, the area under the curve (AUC) was 0.751 (95% confidence interval [CI]: 0.649–0.852), and the cutoff value was 187.5 pg/mL with a sensitivity of 77.4% and specificity of 71.0%. In dichorionic twin pregnancies, the AUC was 0.716 (95% CI; 0.655–0.777), and the cutoff value was 252.5 pg/mL with a sensitivity of 65.1% and specificity of 69.6%. Based on the above cutoff values, univariate and multivariate logistic regression analyses were performed to calculate the odds ratios (OR) for the PLGF levels. After adjustment for potential confounding factors, low PLGF concentrations still significantly increased the risk of discordant fetal growth (monochorionic twin pregnancy: adjusted OR: 7.039, 95% CI: 2.798–17.710, P < 0.001; dichorionic twin pregnancy: adjusted OR: 4.279, 95% CI: 2.572–7.120, P < 0.001).
Conclusions
A low maternal second-trimester PLGF level is considered a remarkable risk factor and potential predictor of discordant fetal growth. This finding provides a complementary screening strategy for the prediction of discordant fetal growth and offers a unique perspective for the subsequent research in this field.
An Optimized Edward-elgamal Extreme Performance Signature Scheme Oedecas in Iot and Blockchain
Authors: R Anusha , Saravanan R.
Published: August 2023

Digital signatures (DS) are the modern-day guardians of authenticity and security in the digital realm. Even though the goal has stayed the same, the scope of its suitability and the boundaries at which it can be applied have necessitated perpetual improvements in speed, safety, and computation. Increased DS secure efficiency is in high demand, especially considering the Internet of Things (IoT), blockchain technology (BC), and cryptocurrencies. Signatures are generated using a digital signature scheme (DSS). To address the nonrepudiation problem of IoT over the Blockchain ecosystem, let us create this scheme. This article explores EdDSA (Edward Curve Digital Signature Algorithm), a popular DSA, along with a proposed hybrid signature, and how it can be implemented in the IoT based on BC. It also compares the Edward, Hyperelliptic, and Elliptic curve cryptography. Then, we compared the Edwards curve digital signature algorithm (EdDSA) to Elliptic Curve DSA(EcDSA) heuristically and Hyper Elliptic Curve DSA(HeDSA). The study results demonstrate that EdDSA is an improvement over ECDSA and HeDSA. From the study, the proposed scheme, Optimized Edward-El Gamal with Extreme performance Edward curve Accumulate signature (OEDECAS), provides more security and is evaluated to be used in the Blockchain and IoT sectors with positive results right away. It shows a 15% improvement in the transaction flow, a 15% improvement in block validation, and tamper-proof security for IoT, like the same system, implemented without OEDECAS.
Antegrade versus retrograde approach for recanalization of ostial or stumpless coronary chronic total occlusion
Authors: Wu Xi , Wu Ming-Xing , Huang Hao-Bo , Liu Zhe , Cai Jie , Zhang Qi-Zhou , Huang He
Published: August 2023

Background Data on the procedural and in-hospital clinical effects of the antegrade-only and retrograde methods for ostial or stumpless CTO PCI are scarce.The purpose of this research was to assess the procedural and in-hospital clinical results of percutaneous coronary intervention (PCI) for ostial or stumpless chronic total occlusion (CTO) using both the antegrade-only and retrograde approaches.Methods We performed a retrospective analysis of the procedural and in-hospital clinical effect of 89 consecutive patients who received ostial or stumpless CTO PCI at our institution between April 2015 and October 2022.Results The antegrade-olny method had a higher technical success rate(92.0% vs.71.9%,p = 0.041 ) and procedural success rate(92.0% vs.68.8%,p = 0.022 ) compared to the retrograde approach (RA) .The RA group had a substantially greater Japanese-CTO (J-CTO) score than the antegrade only approach group (2.45 ± 0.73 vs. 1.64 ± 0.70, p < 0.001). Lesion length of 20 mm or more was notably more prevalent in the RA group than the antegrade-only group (73.4% vs. 28.0%, p < 0.001). The antegrade-only approach group exhibited a higher incidence of microchannels at the proximal stump compared to the RA group (56.0% vs. 10.9%, p < 0.001). In-hospital major adverse cardiac events (MACE) and in-hospital myocardial infarction (MI) were more frequently observed in the RA cases (18.8% vs. 0, p = 0.003; 15.6% vs. 0, p = 0.008). The J-CTO score of less than 2 and the presence of microchannels at the proximal stump were identified as predictors for successful antegrade-only approach PCI for ostial or stumpless CTO (OR: 2.79 [95% CI: 1.92–5.03, P = 0.003]; OR: 2.89 [95% CI: 1.32–6.03, P = 0.001]).Conclusions Compared to RA PCI for ostial or stumpless CTO, the antegrade only approach is utilized for less complex CTO lesions and omes with a reduced likelihood of in-hospital MACE and complications.
Sleep Traits and Hypothyroidism: A two-sample bidirectional Mendelian Randomization Study
Authors: Shi Yinli , Guo Ming , Wang Yuedan , Lin Yan , Zeng Guoduan , Wang Xu , Li Wenting , Wu Mianhua , Li Bo
Published: August 2023

Background: While the link between hypothyroidism and disturbed sleep patterns has been recognized, the available data are inconsistent, making it difficult to establish causality. This study aimed to investigate the causal relationship between certain sleep traits and hypothyroidism.
Methods: Using publicly available genomewide association study (GWAS) data, we applied linkage disequilibrium score regression (LDSC) to identify genetic associations between hypothyroidism and various sleep traits. Two-sample Mendelian randomization (MR) analysis was then conducted to assess the causal relationship between aberrant sleep features and the risk of hypothyroidism. The IVW, MR-Egger regression, weighted median, and weighted mode methods were used. To detect level polymorphism and outliers, MR-Egger regression and MR-PRESSO methods were employed.
Results: A genetic association between hypothyroidism and nap during the day and getting up in morning (rg=-0.0982, p=0.0007; rg=-0.101, p=0.0001). In addition, a causal relationship between hypothyroidism and sleep duration (IVW, OR 1.5208, 95%CI: 0.1082-0.7304, P=0.0082) and getting up in morning (IVW, OR 1.8375, 95%CI: 0.3717-0.8452, P=4.73×10-7). Furthermore, the reverse MR analysis did not reveal any causal link between hypothyroidism and aberrant sleep traits.
Conclusion: MR analysis demonstrated a causal link between hypothyroidism and certain aberrant sleep traits. Sleep duration should be considered as a potential factor in disease models for improving sleep quality and reducing the risk of hypothyroidism.
High-performanceintelligent Models for Faster Ailments Extraction Over the Big Healthcare Data
Authors: Reddy K Nageswara , Narasimhulu K , K RAJENDRA PRASAD , Kumar Y. Jeevan Nagendra , Basha M Suleman
Published: August 2023

Today, predictions for social use are being made in the growing field of social recommended applications. Twitter is a popular platform because it allows millions of users to express their opinions. One of the most emerging areas of study in social mining for large datasets is healthcare prediction. Applying topic models to healthcare data allows for the derivation of predictive insights. An illness or a symptom of a certain health issue is called an ailment. Condition-based evaluation of millions of tweets is performed using the assistance of ailment topic aspect models. The present topic models, which are Latent Semantic Indexing (LSI), Latent Dirichlet Allocation (LDA), and Probabilistic LSI (PLSI), are used for an evaluation of medical outcomes for any one of the ailments' aspects restrictions. Except for adverse effects evaluations of therapies, the state-of-the-art ailments topic aspect model (ATAM) solves the issues and provides healthcare findings for the essential features of ailments data. In order to provide healthcare outcomes over a huge quantity of medical data, ATAM's scalability efficiency is compromised. This paper presents intelligent and highly computational extended ATAM that operates in a distributed environment to solve the scaling issue. Its technique is developed on a multi-node Hadoop system's distributed environment for scalable results. Experiments have been carried out using lakhs of tweets on health and diseases to highlight comparisons between the currently used high-performance models and those recommended.
A causative role for periarticular skeletal muscle weakness in the progression of joint damage and pain in OA
Authors: Kim Ju-Ryoung , Pham Thi Hong Nhung , Kim Hyun Ah
Published: August 2023

Although OA is regarded as a disease of the articular cartilage, recent research has demonstrated alterations in periarticular muscles that surround the affected joint. Here, we investigated changes in periarticular muscle during the progression of osteoarthritis (OA), as well as the cause-and-effect relationship between muscle weakness and OA, in a mouse model of OA by destabilization of the medial meniscus (DMM). Pathological phenotypes in the periarticular muscles were assessed in the early and late stages of OA by DMM. OA pathology and pain behavior in the mice after DMM induction were examined in response to periarticular muscle weakness induced by multiple rounds of barium chloride injections. The examinations were also performed in myostatin knockout mice with strengthened muscle phenotypes by muscle hypertrophy. Morphological alterations in the TA and quadriceps in DMM mice included variations in muscle-fiber size, aberrant ECM deposition, inflammatory cell infiltration, and decreased muscle mass. Periarticular muscle fibers isolated from DMM mice showed reductions in myoblast cell number and myogenic capacity, as well as the proliferation of satellite cells. DMM + muscle injury mice also showed exacerbated joint degeneration compared to the DMM vehicles. Myostatin knockout mice were characterized by attenuated OA and the complete abrogation of pain behavior after DMM. Our results suggest a causative role for muscle weakness in the progression of OA and pain.
Remnant cholesterol and the risk of diabetic nephropathy progression to end-stage kidney disease in patients with type 2 diabetes mellitus: A longitudinal cohort study
Authors: Zhao Yuancheng , Zou Yutong , Wu Yucheng , Yang Jia , Xiao Xiang , Ju Xuegui , Yang Qing , Lang Yanlin , Liu Kai , Liu Fang
Published: August 2023

Aim
Remnant cholesterol has been investigated as a predictor for the progression of DN in type 1 diabetes mellitus patients, as well as the incidence of DN in type 2 diabetes mellitus (T2DM) patients. This study aimed to evaluate the longitudinal relationship between baseline remnant cholesterol and kidney outcomes using a Chinese T2DM with biopsy-confirmed DN cohort.
Methods
We included 334 patients with T2DM and biopsy-confirmed DN during 2010–2019 West China Hospital T2DM-DN cohort. Remnant cholesterol was defined by Martin-Hopkins equation. Patients were divided into four groups based on the median (IQR) remnant cholesterol concentration at the time of renal biopsy. The kidney outcome was defined as ESKD. The relationship between remnant cholesterol and kidney outcome was analyzed using the Kaplan‒Meier method and Cox regression analysis.
Results
The mean age was 51.1 years, and 235 (70%) were men. During follow-up, a total of 121 (36.2%) patients reached ESKD. The Kaplan‒Meier analysis showed that patients in the highest quartile (quartile 4) group had lower cumulative renal survival (log-rank test, p = 0.033) and shorter median renal survival time [34.0 (26.4–41.6) vs 55.0 (29.8–80.2) months] than patients in the lowest quartile (quartile 1) group. By univariate analysis, the high remnant cholesterol group was associated with a higher risk of progression to ESKD. Moreover, the risk of progression to ESKD in the highest quartile was still 2.857-fold (95% CI 1.305–6.257, p = 0.009) higher than that in the lowest quartile, and one-SD increase of remnant cholesterol was associated with a higher risk (HR = 1.424, 95% CI 1.075–1.886, p = 0.014) of progression to ESKD, after adjusted for confounding factors.
Conclusions
High remnant cholesterol is independently associated with a higher risk of ESKD in patients with T2DM-DN, and it may be a new noninvasive marker of ESKD.
Clinical relevance:
Calculated remnant cholesterol has the advantages of being economical and clinically accessible. Moreover, to our knowledge, there are no longitudinal cohort studies for investigating the risk of progression of T2DM-DN to ESKD. In our study, higher remnant cholesterol was associated with a higher risk of ESKD in patients with T2DM-DN, and it may be a new noninvasive predictor of ESKD.
Influence of Meteorological Variables and Air Pollutants on Fog/ Smog Formation in Seven Major Cities of Indo –Gangetic Plain
Authors: Lakra Kanchan , Avishek Kirti
Published: August 2023

The Indo-Gangetic Plains (IGP) of the Indian subcontinent during winters experience widespread fog episodes. The low visibility is not only attributed to meteorological conditions but also to the increased levels of pollution in the region. The study was carried out for Tier 1 and Tier II cities of the IGP of India, including Kolkata, Amritsar, Patiala, Hisar, Delhi, Patna, and Lucknow. This work analyzes data from a period of 33 years (1990–2023) employing the Mann-Kendall Theil-Sen slope to determine the trends in fog occurrence; the relation between fog and meteorological parameters using multiple linear regressions. Furthermore, the identification of the most relevant fog (visibility) - impacting factors from a set of both meteorological factors and air pollutants using step-wise regression. All cities indicated a trend in the number of foggy days except for Kolkata. The multiple regression analysis reveals relatively low associations between fog occurrences and meteorological factors (30–59%) although the association was stronger when air pollution levels were taken into account (60–91%). Relative Humidity and PM10 has the most influence in formation. Overall, the study provides comprehensive insights into fog trends by incorporating meteorological data and air pollution analysis. The findings highlight the significance of acknowledging both meteorological and pollution factors to understand and mitigate the impacts of reduced visibility. Hence, this information can guide policymakers, urban planners, and environmental management agencies in developing effective strategies to manage fog-related risks and improve air quality.
The potential role of Omentin-1 in Obesity-Related Metabolic Dysfunction-Associated Steatotic Liver Disease: Evidence from translational studies
Authors: Salvoza Noel , Giraudi Pablo , Gazzin Silvia , Bonazza Deborah , Palmisano Silvia , de Manzini Nicolò , Zanconati Fabrizio , Raseni Alan , Sirianni Francesca , Tiribelli Claudio , Rosso Natalia
Published: August 2023

BackgroundObesity, characterized by visceral adipose tissue (VAT) expansion, is closely associated with metabolic dysfunction-associated steatotic liver disease (MASLD). Recent research has highlighted the crucial role of the adipose tissue-liver axis in the development of MASLD to its progressive form, metabolic dysfunction-associated steatohepatitis (MASH). In this study, we investigated the potential role of omentin-1, a novel adipokine expressed by VAT, in obesity-related MASLD pathogenesis.MethodsThroughin silicoanalysis of differentially expressed genes in VAT from obese patients with and without MASH, we identified omentin-1 as a significant candidate. To validate our findings, we measured omentin-1 levels in VAT and plasma of lean controls and obese patients with biopsy-proven MASLD. Additionally, we assessed omentin-1 expression in the VAT of a juvenile mice MASLD model.In vitroandex vivostudies were conducted to investigate the effects of omentin-1 on MASLD-related mechanisms, including steatosis, inflammation, ER stress, and oxidative stress. We also analyzed the impact of D-glucose and insulin on VAT omentin-1 levelsex vivo.ResultsCompared to the lean group, the obese groups exhibited significantly lower VAT and plasma levels of omentin-1. Interestingly, within the MASH group, fibrosis did not affect omentin-1 levels. Likewise, VAT of mice fed with high-fat diet, showing histological signs of MASH showed decreased omentin-1 levels as com-pared to their control diet counterpart.In vitroexperiments on fat-laden human hepatocytes revealed that omentin-1 did not affect steatosis but significantly reduced TNF-α levels, ER stress, and oxidative stress. Similar results were obtained usingex vivoVAT explants from obese patients upon omentin-1 supplementation. Furthermore, omentin-1 decreased the expression ofNF-κBmRNA, bothin vitroandex vivo.Ex vivoVAT explants showed that D-glucose and insulin significantly reduced omentin-1 mRNA expression and protein levels.ConclusionsCollectively, our findings suggest that reduced omentin-1 levels contribute to the development of MASLD. Omentin-1 supplementation mitigates inflammation, ER stress, and oxidative stress, probably via inhibiting the NF-κB pathway and might also play a role in the regulation of glucose and insulin metabolism. Further research is warranted to explore omentin-1 as a potential therapeutic target and/or biomarker for MASLD.
Evaluation of groundwater quality in the Takelsa basin (Northeastern Tunisia) for irrigation and drinking suitability using water quality index
Authors: Dhouioui Sabra , Mzali Houcem , Hafsa Kalthoum
Published: August 2023

Groundwater serves as a vital freshwater resource in various regions worldwide. However, the combination of climate change, population growth, intensive agricultural and industrial practices, as well as the proliferation of drilled water wells, has resulted in declining water table levels and deterioration in physico-chemical water quality. This study aims to investigate the hydrogeochemical parameters (concentration of major ions: magnesium (Mg), calcium (Ca), potassium (K), sodium (Na), bicarbonate (HCO3), nitrate (NO3), sulfate (SO4), and chloride (Cl)), pH, Total Dissolved Solids (TDS), and electric conductivity (EC)) to discern the main geochemical processes and origin of groundwater salinity. The findings from the analysis of groundwater samples indicate the prevalence of Na-Cl and Cl-SO4-Ca facies. The mineralization of water is influenced by the dissolution of evaporites (halite, anhydrite, and gypsum), anthropogenic activities (nitrate contamination), and ion exchange processes. Moreover, the Water Quality Index (WQI) calculated from the percentage of sodium (%Na) and the Sodium Adsorption Ratio (SAR) demonstrates that the groundwater in the Takelsa basin is suitable for irrigation purposes but unsuitable for drinking. Furthermore, detailed geological mapping of the Takelsa basin, along with comprehensive field lithostratigraphic cross-sections, has enabled the following outcomes: 1) determination of a new basin structure; 2) identification of various water reservoirs within the Saouaf formation; and 3) characterization of aquifer geometry and features.
Boundary Negotiating Artifacts to Envision the Desired Research Data Infrastructure toward Reproducibility in Data-Intensive Science
Authors: Jeng Wei , Yang Yu-Ju , Chen Hong-Chun , Yang Yi-Jie , Shih Yi-Ru
Published: August 2023

New data-intensive research paradigms and surging volumes of research data have amplified the need for more effective systems of data curation, management, and sharing. This methodological paper focuses on the development and implementation of a workshop protocol aimed at enabling researchers in various sub-disciplines of data-intensive fields to achieve consensus about data-sharing and reproducibility practices. As such, it addresses a key gap in our understanding of how researchers from those sub-disciplines negotiate and reach consensus on disciplinary practices, which is crucially important to the design of research-data infrastructure and data-management support services. Specifically, we first convened a design-thinking workshop, attended by 17 principal investigators from the field of data-intensive health science, which simulated the identification and solution of real-life research problems in a multidisciplinary context. A key plank of our methodology is its use of boundary-negotiating artifacts as a conceptual model to delineate and analyze the artifacts (e.g., Post-its and other notes) that were created and used during the workshop. This approach provided insights into the development and evolution of common practices in the participants’ workplaces. Then, to validate and extend our methodology, we applied the workshop protocol to two additional case studies, respectively involving 30 academic librarians and 13 criminologists. The results confirm the potential applicability and adaptability of our approach to even more data-intensive disciplines, and provide insights that should be valuable to a range of stakeholders including but not limited to national funders, memory institutions, and research establishments.
Disulfidptosis-related signature to guide the prognosis prediction and treatment in hepatocellular carcinoma
Authors: Zhou Yuanzhi , Chen Wenwen , Zhang Xu , Ma Jiaxin , Li Yarui , Song Yiqun , Lu Guifang , Ren Mudan , Yin Yan , He Shuixiang
Published: August 2023

Disulfidptosis, a new cell death process, is tightly linked to the tumor appearance and development. This research established a five-gene disulfidptosis-related signature (DRS) model and a nomogram to comprehensively assess patient prognosis in HCC patients. We identified two clusters, low DRS score group and high DRS score group, significantly different in overall survival and tumor microenvironment (immunoassay and mutational profile). Moreover, HCC patients in high DRS score group responded less favorably than those in low DRS score group to the current first-line therapies (TACE and sorafenib) but were more sensitive to most standard chemotherapy drugs suggesting that patients who are resistant to first-line medications may benefit from trial use of traditional chemotherapy medicines. As well, in vitro experiments showed that a path for the treatment of HCC patient with a worse prognosis may be provided by the ability of phloretin to cause the death of high SLC7A11 expression HCC cells.
Researching how to match supply and demand for ecosystem services based on multi-source data: A Case Study in the Hexi Region, China
Authors: Zhang Xuebin , Li Xuehong , Wang Ziyang , Liu Yue , Yao Litang
Published: August 2023

To achieve the best management of the ecosystem and sustainable socioeconomic development, it is crucial to clarify the matching relationship between the supply and demand of ecosystem services (ESs). Therefore, four types of ESs were chosen for the Hexi region in this study: food supply, carbon sequestration, water yield, windbreak and sand fixation. This study evaluated the supply-demand and matching relationships between various ecosystem services tapping into the InVEST model, the supply-demand ratio of ecosystem services, and the four-quadrant model. It also analyzed the supply-demand ratio of comprehensive ecosystem services and their cold and hot spots. The findings suggest that (1) the overall ESs supply showed an increasing trend, with a spatial pattern of “high in the southeast and low in the northwest”. The demand for food supply and carbon sequestration services has been increasing annually, while the demand for water production and wind and sand prevention services has been declining. The demand space is characterized by a layout similar to the distribution of population, production and living areas, and ecologically vulnerable areas; (2) From the perspective of quantity matching, with the exception of windbreak and sand fixation services which are in short supply, all others are in a state of oversupply. Regrading spatial matching, all ESs are primarily dominated by low-low spatial matching zones, with large areas concentrated in the northwest desert region; (3) The supply-demand ratio of overall ESs shows a fluctuating upward trend. The proportion of cold spots and sub-cold spots, which are mainly concentrated in the northwest region, accounts for more than 50%, while that of hot spots and sub-hot spots is relatively small and mainly appears in the Qilian Mountains of the southern region and a few oasis areas.