bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationships and Activities. The study is supported by OOO AstraZeneca Phar­maceuticals.
Authors: Shlyakhto E. V. , Belenkov Yu. N. , Boytsov S. I. , Villevalde S. V. , Galyavich A. S. , Glezer M. G. , Zvartau N. E. , Kobalava Zh. , Lopatin Yu. M. , Mareev Yu. V. , Tereshchenko S. N. , Fomin I. V. , Barbarash O. L. , Vinogradova N. G. , Duplyakov D. V. , Zhirov I. V. , Kosmacheva E. D. , Nevzorova V. A. , Reitblat O. M. , Soloveva A. E. , Zorina E. A.
Published: July 2023

Heart failure (HF) is a global health problem. Despite advances in the development of effective treatments for patients with heart failure, morbidity and mortality from remain high, and the prognosis is poor. However, there is potential to improve outcomes in HF patients with current disease-modifying therapy. Planning needs and resources, assessing the effectiveness of care for HF patients in clinical practice requires high-quality epidemiological data. Previously performed Russian observational studies of HF were characterized by relatively small sample sizes, inclusion of patients in only one or a few regions, strict selection criteria, single-stage design, or short follow-up. The rationale and design of the all-Russian prospective observational multicenter registry study "PRIORITET-CHF", which included 20000 patients with HF throughout the Russian Federation, is presented. The main aims of the study are to (1) describe baseline clinical and demographic characteristics in outpatients with HF in the Russian Federation and (2) characterize routine therapy and evaluate the compliance of treatment for HF with reduced ejection fraction with current clinical guidelines.
Moderate-intensity statin therapy. Efficacy and safety issues
Authors: Gogolashvili N. G.
Published: July 2023

High rates of cardiovascular (CV) morbidity and mortality dictates the need to determine approaches to therapy that would reduce complications rate and improve patient’s prognosis. High-intensity statin therapy is an integral part of the treatment of patients with high and very high cardiovascular risk. At the same time, there is a large cohort of patients who would benefit from moderate intensity statin therapy. In the present article we have summarized available data on hypolipidemic effects, pleiotropic effects and role of moderate intensity statin therapy, atorvastatin particularly, in reding the risk of major adverse cardiac events.
Análisis del mensaje persuasivo en campañas publicitarias de productos de cosméticos ecológicos desde el Modelo Probabilidad de Elaboración (ELM) y las normas sociales
Authors: Marroquín-Ciendúa Fernando , Rodríguez-Martínez Guillermo , Palacios-Chavarro Janneth Arley , Sandoval-Escobar Marithza
Published: July 2023

En las últimas décadas compañías en el mundo han innovado en la generación de productos amigables con el medio ambiente. La industria cosmética ha venido incursionando en la oferta de productos que propenden por el cuidado y protección de la salud y del ambiente. Para promover estos productos se suele acudir a mensajes persuasivos que vinculan el uso de normas sociales como un mecanismo para incidir positivamente en consumidores, en su mayoría, mujeres. Este estudio busca analizar el mensaje persuasivo de la publicidad gráfica y audiovisual sobre la intención de compra de cosméticos naturales, en mujeres de Bogotá (Colombia), considerando estrategias persuasivas desde las rutas central y periférica planteadas en el Modelo de Probabilidad de Elaboración (ELM) y desde el uso de normas sociales. Para ello, se realizó un experimento factorial 2x2x3 con 216 mujeres. Los hallazgos mostraron mayores intenciones de compra de cosméticos cuando se usan mensajes audiovisuales emocionales combinados con apelaciones hacia las normas subjetivas. Se encontró que las intenciones de compra fueron más evidentes cuando se empleó publicidad que vinculó la ruta periférica de la persuasión, en un medio audiovisual y usando las normas subjetivas. Los resultados sugieren que los mensajes construidos para motivar el consumo ecológico incrementan su efectividad si se diseñan con argumentos que recurren al seguimiento normativo y si se selecciona el medio adecuado. Se concluye que los mensajes persuasivos y el medio de difusión son factores que impactan en las actitudes de los consumidores frente a la preferencia y uso de productos cosméticos proambientales.
Sustaining (Dis)Embodied Inequalities in the(ir) Eurocene: Ancient Microbes, Racial Anthropometry, and Life Choices
Authors: De Lima Hutchison Coll , Núñez Casal Andrea
Published: July 2023

Racialisation and colonialism are central to sustaining (dis)embodied inequalities. We bring together our distinct ethnographic projects to explore this. The first project accompanied a microbiome expedition involving Amazonian Indigenous non/human communities, whereas the second project focussed on medical professional’ encounters with Mbya Guarani communities in the Atlantic Forest region. Both projects explore racialised assumptions of human difference and colonial extractive practices. In the case of medical intervention with the Mbya, and their forms of life, this is perpetuated through the imposition of anthropometric growth standards. With the human microbiome initiatives, identifying Indigenous Peoples as potential reservoirs for novel probiotics also ultimately amplifies racialised (dis)embodied inequalities. Rather than these interventions addressing such disembodied equalities, we draw parallels between the two, to show that they perpetuate them. Finally, we propose that part of ceasing to reproduce these (dis)embodied inequalities requires ‘us’ to challenge the racialised and colonial histories of the life and geological sciences, to recognise their embodied consequences in the present, as well as how they are implicated in emergent proposals for new geological ‘-cenes’.
30-year Review of Ameloblastoma: A tertiary hospital-based study
Authors: Black Alan , Machete Motimedi , Motloba Pagollang
Published: July 2023

Introduction

The clinical, histological and radiographic presentation of ameloblastoma is well described in literature. This odontogenic tumour commonly affect the mandible, locally aggressive and destructive resulting in disfigurement. It arises from dental tissues at various phases of tooth development. They are generally asymptomatic, slow growing, locally invasive and rarely malignant with a high recurrence rate.

Objective

To test the hypotheses that ameloblastomas were predominant in the mandible. among black Africans, male and the young.

Study Design

Retrospective review of ameloblastoma cases spanned between 1991 and 2022.

Methods

Data analysis was based on 185 histologically confirmed cases. Appropriate descriptive and inferential statistics were undertaken on, age, gender, clinical, radiographic and histological characteristics.

Results

The average age was 28.81 (14.53), ranging between 3-75 years. The overall male to female ratio stood at 1.18:1. Ameloblastomas were prevalent in the mandible 174(94.1%), diagnosed as conventional variant 155(83.7%) and acanthomatous subtype. Radiographically, the lesions appeared as multilocular 97(55.4%), radiolucent 100(54.1%) and expansile 129(67.7%). The average size of the lesions was 77.43 ± 33.83 mm, with a range of 184 mm.

Conclusion

Our results validate the hypothesis that ameloblastoma is highly prevalent among black Africans of younger age. The radiographic, clinical, and histological characteristics of ameloblastoma in our population are comparable to the vast literature.
Intervention plan for the protection of APPs: case study of the Espinharas River in the city of Patos - PB
Authors: Silva Emmanoel Marques da , Albuquerque Sheila Rodrigues de , Carvalho Gabriel Lincoln Lopes , Silva Paulo Roberto de Oliveira , Silveira José Augusto Ribeiro da
Published: July 2023

Due to the urbanization processes of recent years, a significant loss of the relationship between water resources and cities has been observed, where Areas of Permanent Preservation (APPs) have been gradually degraded and irregularly occupied. Given these scenarios, laws such as the Forest Code (Federal Law No. 12,651/2012) have been created in an attempt to mitigate and preserve the riparian zones of rivers, mangroves, lakes, ponds, and other water bodies, but due to problems in the applicability of the law itself. Thus, this study proposed to study the PPAs of the Espinharas River in the city of Patos/PB, to highlight interventions that can generate requalification of the river banks. The method of analysis chosen was exploratory research, with the support of techniques such as field visits, photographic surveys, data collection, mapping of PPAs, and finally the diagnosis of land use and watershed. The results of this study consisted of the proposal of a linear park plan applied in the areas of the PPAs of the Espinharas River, urban equipment that has the purpose of providing the requalification, restoration, and renaturalization of the areas degraded by the processes of irregular occupation and urbanization.
How to help managing emotions felt by bipolar patients?
Authors: Michel Bourin
Published: July 2023

The regulation of the control of the emotional experience is one of the determining parameters of the adaptation of an individual to his environment. Bipolar disorder is a psychiatric pathology in which disturbances in the processing of emotions are particularly marked during acute episodes and persist during the interictal period. Treatment with mood stabilizers generally improves the perception of emotions, while antidepressants are brakes on this perception. Finally, simple psychological measures can be useful in controlling emotions.
Effects of prepubertal to peripubertal exposure of triclosan on the reproductive health of the young male laboratory mice
Authors: Shobha Raj , Poonam Singh
Published: July 2023

Over the last few decades, a massive increase in environmental toxicants has played a significant role in causing hindrance in the process of sexual maturity, leading to impaired reproductive health. Several toxicants are existing in the environment because of rapid industrialization, agricultural activities, and urbanization that act as endocrine disrupting chemicals (EDCs). Triclosan (TCS; 2,4,4’-trichloro-2’-hydroxydiphenyl ether) is one of the EDCs, acts as an antimicrobial chemical, and is used widely in personal care products and several commercial preparations as preservatives. It is found to interfere with normal reproduction and sexual maturity. The present study is therefore, aimed to investigate the impact of prepubertal to peripubertal exposure of TCS (300 and 600 mg/kg BW/day from PND 22 to PND 63) to observe the age of the onset of puberty, weights of the reproductive organs, alterations in the levels of testicular cholesterol, serum testosterone, and histopathology of the testis in the young laboratory mice. TCS exposure caused a significant delay in the age of prepuce separation, an indicator of the onset of puberty. Its exposure from PND 22 to PND 63 resulted in significant reductions in the weights of the testis, epididymis, and seminal vesicle, levels of testicular cholesterol, and serum testosterone in the young mice at PND 64. Testicular histology of such mice also showed regressive changes in the seminiferous tubules, indicating the interference of TCS in the process of spermatogenesis. The findings of the present study, therefore, reveal that TCS delays the age of onset of puberty and interferes with the endocrine functions of the testis.
Protocol for neurophysiological imaging in human iPSC-derived neurons v1
Authors: Garcia Perez Natalia
Published: July 2023

The protocol describes how to perform neurophysiological imaging experiments on different types of human iPSC-derived neurons.
DNA Barcoding Protocol for Darwin Tree of Life at The Natural History Museum of London v1
Authors: Beasley Jordan
Published: July 2023

This protocol outlines the DNA barcoding process at the Natural History Museum of London (NHM) for the Darwin Tree of Life project (DToL). DNA barcoding is used as part of the species identification process and sample tracking to check that the genome sequence corresponds to the material that was sent.
Multifiber Array Fabrication v1
Authors: Vu Mai-Anh
Published: July 2023

We have developed a multi-fiber photometry approach to monitor dopamine release with sub-millimeter spatial resolution and sub-second temporal resolution at over 50 locations simultaneously throughout the striatum in awake, behaving mice expressing a fluorescent sensor. This protocol includes the array fabrication and pre-implant mapping steps. Please contact us (mwhowe@bu.edu) if you are interested in using this technique.
An adaptive method based on PC-Kriging for system reliability analysis of truss structures
Authors: Chen Pengyu , Zhao Cunbao , Yao He , Zhao Shengnan
Published: July 2023

In practice, a truss consists of a large number of members which makes it a complex system. This leads to difficulties to estimate the system reliability due to computational costs. An adaptive method is thereby proposed to deal with this issue. It constructs a global metamodel to quickly estimate the rough reliability index of a truss. According to the estimated reliability index, the differential evolution algorithm is performed to generate more samples located in an expanded domain so that more representative failure modes can be identified. Combined with AK-SYSi, local metamodels of representative failure mods are built, and updated through active learning. When the convergence criterion is satisfied, the results of system reliability analysis can be obtained. Eventually, two examples of truss structures are studied to illustrate the superiority of the proposed method in balancing accuracy and efficiency. The results indicate that the proposed method makes a good balance between accuracy and efficiency when it is applied to analyze the system reliability of the truss.
Improving portfolio liquidity
Authors: Kovač Dujam , Podrug Doris
Published: July 2023

This article describes how investors on the Zagreb Stock Exchange (ZSE) can use Multiple Criteria Decision Making (MCDM) to select shares for investment. Both financial and market liquidity criteria are used to compare different shares. Market liquidity criteria include the average number of daily trades and the average daily turnover on the regular market. These criteria help to determine the liquidity of shares in the secondary market, which is the main contribution of this research.The investment selection proposal is based on the PROMETHEE. The performance of the portfolio constructed using the Modern Portfolio Theory (MPT) was tested. Predictably, the inclusion of liquidity criteria in the share selection process resulted in an increase in the liquidity of the portfolio, an effect that is clearly evident after 2019. However, such a portfolio does not provide significantly different returns compared to a scenario where liquidity criteria are excluded from share selection process. Reading this paper provides an insight into how to make investment decisions based on criteria consistent with investors’ objectives in an developing capital market.
Adherence to journalistic standards in coverage of religious issues in Ukrainian and Italian media
Authors:   Taras Shevchenko national University of Kyiv, Zhelihovska Nataliia , Gmyria Artur ,   Taras Shevchenko national University of Kyiv
Published: July 2023

This article aimed to investigate the adherence to professional standards by the Ukrainian and Italian media in covering the conflict around the UOC MP (Ukrainian Orthodox Church of the Moscow Patriarchate) during the war in Ukraine. Thanks to the method of scientific literature analysis, Ukrainian scholars’ views on professional journalistic standards and their observance in the media were clarified. With the help of the media monitoring method, we found 97 publications covering the conflict around UOC MP. The content analysis method determined the subject of the relevant publications and the presence of Russian propaganda narratives in them. Quantitative and qualitative adherence indicators to professional standards were also determined using the content analysis method, and the context mentioning the OCU and UOC MP activities was clarified. The main results and conclusions of the study: most of Italian media had a neutral attitude to the conflict, some media ignored it, there were also those openly promoting Russian narratives and even sometimes containing hate speech (Il Giornale) and reacted sharply to the fact of the searches and the statement of Volodymyr Zelenskyi about the banning of the UOC MP (Avvenire). Despite occasional standards violations, Ukrainian media covered the events objectively and in a balanced manner, without inciting enmity towards UOC MP.
Migration Law and Issues in Sports
Authors: Nafziger James A.R.
Published: July 2023

The international migration of athletes has become an essential feature of sports competition. These days foreign travel is often the name of the game. The purposes and duration of such migration range from participation in single events to long-term, even permanent relocation involving professional transfers. Each purpose or duration may generate a different body of law and regulations. Varying national visa, residence and other requirements for territorial entry of noncitizens are of course essential. Regional, especially European Union law may also be foundational as it was, for example, in defeating a practice within the EU of transfer payments between clubs in different member states that impeded freedom of movement. Also applicable is international law, notably that of the several institutions within the Olympic Movement insofar as it is one of the very few NGOs vested with international legal personality. Supporting that legal authority or extending beyond it are bilateral treaties of friendship and cooperation. More broadly, international human rights law applies, particularly in reinforcing the rights of athletes to be free of political discrimination against their participation in international competition.
The Straight Baselines under the Convention on the Legal Status of the Caspian Sea: Iran’s Approach
Authors: Abadikhah M.
Published: July 2023

In 2018, the Presidents of Azerbaijan, Iran, Kazakhstan, Russia and Turkmenistan signed the Convention on the Legal Status of the Caspian Sea (the Aktau Convention). Despite this, some specific issues related to the straight baseline, remain unresolved. The result is that Iran has yet to ratify the Convention subject to negotiations concerning a separate agreement in the future. Since 2018, the signatories to the Aktau Convention have not reached an agreement in the course of negotiations on a separate agreement. The main question raised in the article is why Iran ha s not ratified the Aktau Convention yet. The paper shows that the authorization of the convention under Para. 4 Art. 1, the specific shape of Iran’s coastline, and the lack of agreement in the negotiations related to the special agreement prevented Iran from ratifying the Convention. The paper finally concludes that the border delimitation considered by Iran differs from the border delimitation agreed on by the four other states, namely Russia, Kazakhstan, Azerbaijan and Turkmenistan, and it is only when the straight baseline is established with respect to Iran’s will and model that Iran will complete the ratification process.
The Main Directions of the International Legal Policy of the Republic of Tajikistan at the Present Stage
Authors: Rajabov S. A.
Published: July 2023

The article is devoted to topical issues related to ensuring peace, security and cooperation among the states of the Central Asian region. It pays great importance to international law as the most important means of implementing the foreign policy of the states of the region and as the basis for maintaining the modern world order. It considers such areas of the international legal policy of the Republic of Tajikistan at the present stage as the protection of the state independence and national security of Tajikistan at the international level; development of trusting relations, friendship and cooperation with all countries of the world, especially with the countries of Central Asia on the basis of mutual interests; protection of the rights and freedoms of citizens of Tajikistan abroad; combating terrorism, extremism and crime in general; cooperation in solving global environmental, water and climate problems; cooperation in the field of labor migration, taking into account the protection of the rights of Tajik migrants in foreign countries; cooperation in order to preserve the identity, national identity and self-knowledge of the Tajik people. The detailed consideration of main directions makes a unique contribution to the understanding of the international legal policy of the Republic of Tajikistan at the present stage.
Autosensitization to human chorionic gonadotropin: etiology, role in reproductive loss, and approaches to therapy
Authors: Tkhai Daria V. , Chepanov Sergey V. , Arzhanova Olga N. , Bespalova Olesya N. , Selkov Sergey A.
Published: July 2023

The important role of human chorionic gonadotropin in pregnancy suggests the occurrence of reproductive disorders due to the circulation of specific antibodies, especially in early pregnancy, which can lead to a cascade of pathological reactions such as implantation failure, placentation, trophoblast invasion, and ultimately fetal rejection. The lack of knowledge and the complexity of diagnosing and treating this autoimmune pathology in reproductive medicine and obstetrics negatively affects both the outcomes of each individual pregnancy and the demographic situation as a whole. This review article highlights the main ideas about the causes of human chorionic gonadotropin antibody occurrence, the pathological mechanisms, the reproductive and obstetric complications associated with human chorionic gonadotropin autoantibodies, diagnostic methods, and therapeutic approaches.
Current views on the diagnosis and prognosis of fetal growth restriction (A literature review)
Authors: Ignatko Irina V. , Bogomazova Irina M. , Kardanova Madina A.
Published: July 2023

Fetal growth restriction remains a leading cause of preterm birth and neurological disorders in children and is associated with high neonatal and perinatal morbidity and mortality. Fetal growth restriction is strongly associated with preeclampsia, placental insufficiency, and does not tend to decrease in frequency. The terms small for gestational age and fetal growth restriction are similar in terms of fetometry, however, in modern literature, these concepts differ based on blood flow disorders in the mother-placenta-fetus system and perinatal complications. A deep understanding of the multifactorial pathogenesis of early and late fetal growth restriction will allow for developing targeted therapy of placental insufficiency. Determining the role of new placental growth biomarkers plays a significant role in understanding the pathogenesis of placental dysfunction and developing measures to predict placenta-associated pregnancy complications.
This review article highlights new approaches to effective fetal growth restriction screening. Recent advances in ultrasound diagnosis of fetal growth restriction provide the basis for multivariate testing that can provide cost-effective screening for placental-associated pregnancy complications, including fetal growth restriction.
Psycho-emotional status in patients with endometriosis-associated pain syndrome in various disease phenotypes
Authors: Shalina Maria A. , Yarmolinskaya Maria I. , Netreba Elena A. , Beganova Alexandra K.
Published: July 2023

BACKGROUND: Patients with endometriosis-associated pain syndrome in combination with anxiety or depression have lower treatment effectiveness and satisfaction with both the disease itself and the pain syndrome compared to patients with pain syndrome but without depression or anxiety.
AIM: The aim of the study is to assess the relationship between psychosocial status and endometriosis-associated pain syndrome in patients with different phenotypes of endometriosis using pain assessment scales, psychosocial state assessment scales, and quality of life assessment scales.
MATERIALS AND METHODS: We examined 81 patients using a number of questionnaires: Visual Analogue Scale, Numeric Rating Scale, Hospital Anxiety and Depression Scale, Beck Depression Scale, Spielberger State-Trait Anxiety Inventory, and Short Form-36 quality of life assessment. The patients were divided into three groups: isolated adenomyosis (n = 39), adenomyosis combined with external genital endometriosis (n = 21), and the control group (n = 21).
RESULTS: Our study has shown that patients with adenomyosis combined with external genital endometriosis had the highest scores on all questionnaires for assessing anxiety and depression, as well as a low quality of life in general, which significantly differed from those in the control group (p 0.05). The results in the group of women with isolated adenomyosis are not so unambiguous and, overall, somewhat better than in the group of patients with adenomyosis combined with external genital endometriosis, but significantly worse compared to the control group. When assessing the severity of dysmenorrhea, higher scores were also found in the group of women with adenomyosis combined with external genital endometriosis: 6.64 2.11 cm (Visual Analogue Scale) and 6.9 2.05 cm (Numeric Rating Scale), while in the group of women with isolated adenomyosis, the scores were 5.29 1.9 cm and 5.83 1.72 cm, respectively (p = 0.028). Women in the control group had no pain syndrome.
CONCLUSIONS: Poor mental and physical health scores obtained in this study in women with external genital endometriosis dictate the need for an objective and multicomponent assessment of the psycho-emotional status in patients, followed by complex treatment and team management with related specialists.
EXAMINATION OF THE RELATIONSHIP BETWEEN DIGITAL LITERACY AND CYBERLOAFING LEVELS OF GIFTED STUDENTS
Authors: GÖNÜLTAŞ Ayşe , AVCU Yunus Emre , TAŞDELEN Afra Selcen , HÜNERLİ Selçuk
Published: July 2023

The purpose of this study is to investigate the levels of cyberloafing and digital literacy that are present among gifted secondary school students and to find the correlation between these two factors. The correlational screening model was used in this study. Participants were 179 secondary school (5th, 6th, 7th, and 8th grade) students enrolled in Science and Art Centers (SAC), who were identified as gifted in one or more fields. The participant information sheet, the Digital Literacy Scale and the Smartphone Cyberloafing Scale were used for the data collection. Data analysis was performed using SPSS 22 software. The mean scores were determined in order to gain an understanding of the levels of cyberloafing and digital literacy as shown by gifted students. The Pearson correlation test was used to investigate the association between digital literacy levels and cyberloafing levels of gifted students. The results showed that gifted students have high levels of digital literacy and low levels of cyberloafing. Pearson’s correlation test results reveal that there was no significant relationship between gifted students' digital literacy levels and cyberloafing levels (p>.05, r= -.084). It is recommended to explore the factors influencing the cyberloafing levels of gifted students, as well as to analyze the cyberloafing and digital literacy of gifted students with different and larger samples, backed by qualitative studies in various age groups.
Kleine Levin Syndrome: Is it just a sleep disorder? A review of psychiatric features during symptomatic and asymptomatic periods
Authors: Gadoth Natan
Published: July 2023

Kliene Levin syndrome (KLS) is a peculiar sleep disorder of youth, consisting of idiopathic periodic hypersomnia attacks associated with behavioral and sometimes psychiatric symptoms during an attack. With the growing awareness of the syndrome and a steep rise in published cases, it became evident that psychiatric abnormalities may be present before the onset of hypersomnic events, in between events and first appear following years after complete recovery. Those observations suggest that psychiatric morbidity may be part of the symptomatology of KLS. In the present paper the results of a systematic literature search of publications using the key words KLS with psychiatric features, Atypical KLS, KLS like, KLS mimic and sleeping beauty syndrome will be discussed, in attempt to support the view that KLS is indeed a neuropsychiatric disorder and not just a sleep disorder of youth. Moreover, the recognition that KLS might imitate psychosis and other psychiatric disorders in which periodic hypersomnia is present, may decrease the number of KLS patients in whom the correct diagnosis may be delayed or totally missed.
Development of Holoeyes Holographic Image-Guided Surgery and Telemedicine System: Clinical Benefits of Extended Reality (Virtual Reality, Augmented Reality, Mixed Reality), The Metaverse, and Artificial Intelligence in Surgery with a Systematic Review
Authors: Sugimoto Maki , Sueyoshi Takuya
Published: July 2023

Image-guided surgery using XR (extended reality: VR/AR/MR) technology has the potential to revolutionize the field of surgery by improving surgical accuracy, reducing procedure time, and enhancing communication and collaboration among the surgical team. We have developed a web-based system, Holoeyes, integrating XR, AI, and metaverse technology to facilitate holographic image-guided surgery. Holoeyes extracts organ shape data from CT or MRI scans and renders them with positional information to obtain X, Y, and Z coordinates. These coordinates are then converted into polygonal information for use in XR technology. The medical device, Holoeyes MD, was developed to create XR applications for surgical planning and navigation. It provides an immersive experience for the surgical team, improving both accuracy and efficiency. The integration of the metaverse in surgery allows for spatial conferencing and review of training, and the avatars replicate the hand and eye movements of the actual surgical procedure. Our Holoeyes system has already been utilized in numerous institutions for pre-and post-operative conferences, surgical planning, and surgical records, with multiple people wearing the headset and sharing information about the pathology, extent of resection, and layers of dissection from all directions. We conducted a systematic review of the literature to investigate the effectiveness of Holoeyes, focusing on the use of XR and the metaverse in surgery. We believe that Holoeyes has the potential to become an indispensable tool in the field of surgery, and we encourage further research and development in this field.
Teachers in Malta, their professional identity and their experience of school closures as a result of the COVID-19 pandemic
Authors: Calleja Colin
Published: July 2023

One of the impacts of the COVID-19 pandemic has been the way we organised teaching and learning. This research paper evaluates the exterience of teachers in Malta during the initial stages of school closures and the way they have been forced to adapt their practices in order to meet the needs of their learners and wider communities. Teachers were expected to change their instructional methods and operate largely through remote teaching. The way teachers’ practices were transformed impacted on their sense of professional identity, and four themes which help to evaluate the re-imagining of teachers’ identities are explored: the professional expectations on teachers, the new technological skills and knowledge teachers were expected to acquire, teachers’ stress, and teachers’ identity and sense of agency. These themes help to bring to the fore teachers’ narratives of their newly acquired practices, but also a realisation of the need for professional learning and a vision that supports teachers in similarly challenging scenarios.
ÇOCUKLARDA HELİKOBAKTER PYLORİ ENFEKSİYONU İLE PLAZMA 25 HİDROKSİ VİTAMİN D3 DÜZEYİ ARASINDAKİ İLİŞKİ
Authors: Evirgen Şahin Gülseren , Kasırga Erhun , Ayhan Semin
Published: July 2023

OBJECTIVE: The severity of the Helicobacter pylori (H.pylori) infection and the presence H.pylori related diseases are affected by host, bacterial and environmental factors. In this study it is aimed to show relationship between H.pylori infection and plasma Vitamin D3 (vitD3) has significant role in regulation inflamatory response in children with H.pylori infection.
MATERIAL AND METHODS: Two hundred one patients aged between 3-18 years, referred to pediatric gastroentrology department of Celal Bayar University Medical Faculty between March 2010 to March 2011 and performed upper gastrointestinal endoscopy because of gastrointestinal symptoms and iron deficiency anemia refractory to medical therapy were enrolled in this study. Histopathologic diagnosis of biopsy speciments of the patients were evaluated. There were 98 patients in H.pylori positive group and 103 patients in H.pylori negative group. Plasma level of vitD3 of H.pylori positive and H.pylori negative cases were compared. Relationship between gastric mucosal activity the degree of inflammation severity and vitD3 level were evaluated in the H.pylori positive group.
RESULTS: Vitamin D3 levels were low in 80 (81.6%) H.pylori positive patients and in 76 (73%) H.pylori negative patients. This difference was not statistically significant (p>0.05). The mean value of plasma level of vitD3 H.pylori positive and negative groups were 15.64±8.9 ng/mL and 16.36±11.35 ng/mL respectively. The difference between the groups was not statistically significant (p>0.05). When patients in H.pylori positive and negative groups were classified according to plasma vitD3 level in four different groups as severe deficiency, deficiency, insuficiency and sufficiency. Vitamin D3 severe deficiency in H.pylori positive group was statistically more frequent than H.pylori negative group (p<0.05). Severity of chronic inflamation and tissue H.pylori activity increased inversely with the mean vitD3 level in both groups (p<0.05).
CONCLUSIONS: Results of this study suggests that vitD3 deficiency is common in children in our region. Vitamin D3 deficiency is risk factor for H.pylori infection. The findings of this study shows vitD3 increasing antibacterial effect and reducing the severity of inflammation in H.pylori infection.
ATORVASTİN VE ROSUVASTATİNİN NEDEN OLDUĞU MİYOPATİYE KARŞI KAFEİK ASİD FENETİL ESTERİN KORUYUCU ETKİSİ
Authors: Şen Serkan , Yılmaz Canan
Published: July 2023

AMAÇ: Statinlerin bazı hastalarda myopatiye yol açması nedeni ile hastanın tedaviye uyumu azalmakta, ilacın kullanılmasına son verilmekte veya kullanılan ilaç değiştirilmektedir. Bu çalışmada statinlerin myopatiye neden olabileceği iki durum olarak oksidatif stress ve inflamasyon üzerinde çalışılmış ve Kafeik asit fenil ester (CAPE)’in koruyucu rolü deneysel olarak test edilmiştir.
GEREÇ VE YÖNTEM: Çalışmada rabdomiyosarkom (RD) hücre hatları kullanılmıştır. Hücreler kontrol, atorvastatin, rosuvastatin, CAPE, atorvastatin+CAPE ve rosuvastatin+CAPE olmak üzere 6 gruba ayrılmıştır. Spektrofotometrik olarak Total Antioksidan Kapasite (TAC), Total Oksidan Kapasite (TOC) ve Oksidatif Stres İndeksi (OSI) analizleri yapılmış; İnterlökin 6 (IL-6) düzeyleri hem protein düzeyinde hem de real time PCR ile mRNA ekpresyonu düzeyinde gösterilmiştir.
BULGULAR: Kontrol grubunda 1739 olan OSI atorvastatin uygulaması ile 3814’e çıkmış, atorvastatinin CAPE ile kombinasyonu sonucunda ise 2109’a inmiştir. Rosuvastatin ve Rosuvastatinin CAPE ile kombinasyonu sonucunda kontrol grubuna göre OSI bakımından bir değişiklik olmamıştır. Atorvastin grubunda IL-6 mRNA ekspresyon düzeyleri kontrol grubuna benzer bulunurken, Rosuvastatin grubunda kontrol grubuna nazaran 2,369 kat artış gözlenmiştir. Rosuvastatinin CAPE ile kombinasyonu neticesinde IL-6 mRNA ekspresyon düzeylerinin kontrol grubu seviyesine çekildiği tespit edilmiştir.
SONUÇ: Bu çalışmada Atorvastatinin RD hücre hatlarında oksidatif stresi tetiklediği, rosuvastatinin ise IL -6 mRNA ekspresyon düzeyini artırarak proinflamasyona giden sürecin önünü açtığı gözlemlenmiştir. Atorvastatinin neden olduğu oksitadif stresin ve rosuvastatinin neden olduğu inflamasyonun baskılanmasında CAPE kombinasyonunun işlevsel olduğu tespit edilmiştir. Bu bakımdan tedavide atorvastatin ve rosuvastatinin CAPE ile kombinasyonunun statinlerin neden olduğu kas hasarı üzerine hasta yararına olumlu sonuçlarının olabileceği gösterilmiştir.
Конкуренция в российской экономике
Authors: Абдуллин Р.Р.
Published: July 2023

Конкуренция является одним из важных факторов развития экономики. Существуют различные формы конкуренции, включая совершенную, монополистическую, олигополию и монополию. Совершенная конкуренция отличается низкими ценами на продукцию, но отсутствует возможность для инновационных разработок. Данная статья рассматривает характеристики каждой формы конкуренции на примере Российской экономики.
Влияние страха сотрудника полиции на эффективность выполнения оперативнослужебных задач
Authors: Науменко С.В , Шеин А.Н
Published: July 2023

Статья посвящена изучению влияния страха на успешность профессиональной деятельности сотрудника полиции. Авторы проанализировали риски и механизмы страха как эмоционального состояния. В заключение приведены практические рекомендации,направленные на оптимизацию состояния сотрудников в экстремальных ситуациях профессиональной деятельности.
Взаимосвязь здорового образа жизни и социальной зрелости личности
Authors: Орлова А.Н , Лесникова Г.Н.
Published: July 2023

В представленной работе поднимается вопрос влияния здорового образа жизни на социальную зрелость личности. Рассматриваются основные социальной зрелости личности, при этом происходит поиск линий соприкосновения и степени влияния физического воспитания на уровень социализации личности
The servitization of business among industrial companies in Catalonia
Authors: Kamp Bart , Vallverdu Carmen , Sisti  Eduardo ,   Universidad de Deusto
Published: July 2023

The concept of servitization refers to the trend among manufacturing companies to base their business not only on produced goods, but increasingly on services. This implies expanding the portfolio of value propositions in the market, integrating and linking them in the form of complete solutions. In turn, it implies generating revenue from the provision of services and/or charging for products as if they were services. This study conceptualizes the phenomenon of servitization, presents the state of the art among the Catalan industry (meso-economic perspective) and collects experiences of 8 Catalan companies (micro-economic perspective) to investigate barriers and benefits of servitization. At this time when all territories in the world are facing complex challenges, among which the climate emergency stands out, there is a need for profound social transformations. Moreover, the requirement that these transformations should be of a democratizing nature is also proving to be a relevant topic.
La servitización del negocio entre empresas industriales de Cataluña
Authors:   Universidad de Deusto, Kamp Bart , Vallverdu Carmen , Sisti  Eduardo
Published: July 2023

El concepto servitización hace referencia a la tendencia existente entre las empresas manufactureras de basar sus negocios no solo en los bienes producidos, sino cada vez más en los servicios. Esto implica ampliar la cartera de propuestas de valor en el mercado, integrar y enlazarlas en forma de soluciones completas. A su vez, implica generar ingresos por la prestación de servicios y/o cobrar por productos como si fueran servicios. El presente estudio conceptualiza el fenómeno de la servitización, presenta el estado de cuestión entre la industria catalana (perspectiva meso-económica) y recoge experiencias de 8 empresas catalanas (perspectiva micro-económica) para indagar en barreras y beneficios de la servitización.
JUDICIALIZAÇÃO REALIZADA PELO UNICEF DE CRIANÇAS E ADOLESCENTES DE 1990 A 2018: BIOPOLÍTICA E NECROPOLÍTICA
Authors: Lemos Flávia Cristina Silveira , Ribeiro Correa Michelle , Teixeira de Barros Neta Fernanda , Silva Santos Souza Giane , Correa Luz Helder , Duarte Guerra Jureuda
Published: July 2023

Resumo: O Fundo das Nações Unidas para a Infância (UNICEF) privilegia a gestão da vida e dos direitos por meio de ações no campo da promoção, garantia e defesa. Para tanto, dos corpos higienizados pela oferta de saberes e de técnicas com manuais de saúde e de educação em direitos humanos para a gestão da vida, em termos de ampliação da produtividade de crianças e adolescentes; sobretudo, às quais, passou a denominar como estando em risco. A problemática de redução das possibilidades de existência à judicialização silencia os aspectos políticos, subjetivos, culturais e sociais que também fazem parte do governo das condutas. As tecnologias de poder e de saber de regulação da população pela entrada da vida na história, como espécie passou a ser chamada por Michel Foucault (1988) de biopolítica e necropolítica. A ligação entre biopolítica e disciplina passou a ser chamada de biopoder, por Foucault e esteve vinculada aos contextos judicializantes da existência, dos corpos, das relações sociais e da política.
BURNOUT NOS PROFESSORES DE ENFERMAGEM EM CENÁRIO DA PRÁTICA
Authors: Lima Amanda Moraes , Alves Monique Milano , Dagostin Valdemira Santina , Losso Ana Regina da Silva , Birollo Ioná Vieira Bez , Soratto Maria Tereza
Published: July 2023

Estudo com objetivo de identificar o nível de burnout nos professores de enfermagem em cenário da prática. Pesquisa de abordagem quantitativa, descritiva, exploratória e de campo. O estudo foi desenvolvido com 19 professores que realizam atividade teórico-prático e/ou supervisão de estágio do Curso de Enfermagem de uma universidade comunitária em Santa Catarina. Aplicou-se escala de Maslach Burnout Inventory (MBI). Na análise de dados quantitativos, as informações foram quantificadas através do Microsoft Office Excel e apresentados por meio de análise quantitativa. O resultado da pesquisa realizada identificou 10,53% com síndrome de burnout. Sugere-se que a instituição busque formas de melhorar a qualidade de vida no trabalho, realizando um levantamento das necessidades dos professores que atuam no cenário da prática, oportunizando reflexão sobre a importância do cuidado do cuidador para a qualificação do cuidado.
PRESCRIÇÃO FARMACÊUTICA
Authors: Izidoro Eduarda Souza da Silva
Published: July 2023

Este trabalho tem como objetivo caracterizar e avaliar a Prescrição Farmacêutica nos aspectos pertinentes.A Prescrição Farmacêutica consiste em uma das atividades que engloba a prática orientada para a atenção aos clientes no que tange o processo de automedicação responsável. É uma atividade fundamental do profissional de Farmácia, onde ao executar a triagem clínica, orienta o paciente para a busca da solução do problema. É fundamental o amplo conhecimento dos medicamentos isentos de prescrição, lembrando que o aconselhamento inclui tanto orientações e prescrição como também os devidos encaminhamentos para profissionais especializados. Os farmacêuticos acreditam que a prescriçãofarmacêutica aumenta a satisfação no trabalho, eleva o status da profissão e melhora a utilização dehabilidades, que geralmente são subutilizadas.
Metaanaliza najvidnejših družbenih medijev v letu 2023
Authors: Brdnik Saša , Polančič Gregor
Published: July 2023

Monografija »Analitični pogled na najvidnejše družbene medije v letu 2023« na primeru analize enajstih družbenih medijev predstavlja strokovni vpogled v trenutno pokrajino najbolj priljubljenih družbenih medijev. Ta prispevek je namenjen sintezi in primerjavi obravnavanih družbenih medijev s primerjavo konceptov, kot so identiteta, skupine, prisotnost, odnosi, deljenje, sloves in pogovori ter primerjavo metrik, uporabljenih za njihovo analizo. Pri tem sta deljenje in sloves v vzorcu prepoznana kot dva najpomembnejša gradnika. Ugotavljamo, da so zasebni in javni pogovori skupna funkcionalnost vseh opazovanih družbenih medijev; Discorda, Facebooka, Instagrama, Linkedina, Pinteresta, Reddita, Snapchata, TikToka, Twitcha, Twitterja in YouTuba. Prevladujoč objekt deljenja v opazovanih družbenih medijih so video vsebine. Prepoznali smo presek metrik za merjenje konceptov pretvorbe, skrbi za stranke, vključenosti in zavedanja med različnimi družbenimi mediji. Te metrike so stopnja konverzije, razmerje med prikazi in kliki, odzivni čas, stopnja odziva, stopnja vključenosti, skupno število vključenih uporabnikov, število prikazanih objav in vključenih uporabnikov ter demografski doseg.
LinkedIn
Authors: Justinek Tilen , Žvegla Jan , Klojčnik Štef , Kavčič Rene , Vrbanec Ferk Nino
Published: July 2023

LinkedIn je družbeno omrežje, ki je postalo ključno orodje za vzpostavljanje poslovnih povezav in iskanje zaposlitve. Dosedanje raziskave so se osredotočile na različne vidike LinkedIna in njegovo vlogo pri razvoju kariere ter povezovanju strokovnjakov z različnih področij. Eden od pomembnih vidikov raziskav je bila analitika in merjenje uspešnosti na LinkedInu,. s fokusom na določanju ključnih metrik, kot so število povezav, aktivnost uporabnikov, angažiranost in vplivnost posameznikov v njihovem strokovnem omrežju. Te metrike so pomembne za merjenje učinkovitosti posameznika ali organizacije na platformi. Poleg tega so raziskave razkrile, da je LinkedIn učinkovit pri prepoznavanju lažnih profilov. S pomočjo algoritmov in analize vsebine so raziskovalci ugotovili, kako identificirati in odstraniti lažne profile, kar pripomore k večji zanesljivosti in verodostojnosti omrežja. LinkedIn je izgubil velik delež uporabnikov, ko je bilo le-to leta 2016 prepovedan v Rusiji. To je pritegnilo pozornost raziskovalcev, ki so preučevali vpliv političnih in pravnih odločitev na uporabo družbenih omrežij ter njihov razvoj v različnih državah. V zaključku je jasno, da je LinkedIn pomemben in vse bolj priljubljen med strokovnjaki in organizacijami za vzpostavljanje poslovnih povezav. Znanstvene raziskave so prispevale k boljšemu razumevanju platforme, njenih metrik in učinkovitosti ter k razvoju strategij za uspešno uporabo LinkedIna v poslovnem svetu.
Pinterest
Authors: Zadravec Staša , Portir Lan , Kapun Žiga , Ostanek Gal , Butolen Nejc
Published: July 2023

V prispevku smo povzeli in predstavili družbeno omrežje Pinterest. Osredotočili smo se na njegove ključne lastnosti, funkcije, ter vse možnosti , ki jih nudi uporabnikom. Zaradi njegovega velikega začetnega uspeha, pa tudi ogromnega števila današnjih uporabnikov, spada Pinterest v vrh najbolj priljubljenih družbenih omrežij. Skozi seminarsko nalogo smo se spraševali kako je Pinterest sploh postal Pinterst kot ga poznamo danes, kdo so njegovi ustanovitelji, ter kaj ga loči od konkurence. Poglobili smo se v funkcije družbenega omrežja, tako osnovne, kot napredne, ter predstavili najbolj priljubljene tako med nami – avtorji, kot tudi med drugimi uporabniki. Zaradi vedno večje rasti vplivnežev ter vpeljevanja podjetij v svet socialnih omrežij smo raziskovali možnosti, ki jih Pinterest omogoča na področju analitike in nadzorovanja profila. Tako lahko med omenjenimi števili in podatki najdemo vse od podatka koliko sledilcev imamo, do števila omemb našega profila s strani drugih podjetij. Se pa Pinterest ne uporablja zgolj kot samo orodje za deljenje slik, temveč ima tudi veliko drugih funkcionalnosti, vse od slikovnega iskalnika, do platforme ki ozavešča o zdravju.