bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Islamic Philosophy an Authentic Philosophy?
Authors: VURAL Mehmet
Published: January 2024

The question of whether Islamic philosophy can be considered as an authentic form of philosophy has been a subject of prolonged discourse. Various perspectives have emerged, presenting three distinct approaches to this matter. The first approach, primarily advocated by orientalists, contends that Islamic philosophy lacks authenticity. Contrarily, the second viewpoint asserts that while Islamic philosophy exhibits eclecticism, it represents a form of creative eclecticism. Finally, the third perspective posits that Islamic philosophy is unequivocally authentic, affirming its rightful place within the realm of philosophical discourse. Regrettably, Islamic philosophy, despite its profound significance during the Middle Ages, has not received the recognition it truly deserves within the pages of philosophical history books. Authors have often allocated only brief sections to this rich philosophical tradition, overlooking its depth and influence. It is frequently emphasized that Islamic philosophy serves as a continuation of Greek philosophy, acting as a vital bridge that connects the realms of Ancient Greek philosophy and medieval Western philosophy. Orientalists regarded Muslim philosophers as mere interpreters of Ancient Greek philosophers, ignoring their philosophical authenticity. Recent studies have revealed that this prejudiced approach of the orientalists is fallacious. Medieval Islamic philosophy, which reached its golden age during the 9th-13th centuries, began to be rediscovered. Islamic philosophy introduced completely novel themes with Sufism and theology, and, developed fresh and innovative perspectives by integrating Greek philosophy. In particular, unique insights and movements have been put forward on subjects such as Ghazalism, Illuminationism, Eastern philosophy, occasionalism, methodical skepticism, the theory of creation ex nihilo, prophecy, the relationship between philosophy and religion, and critical analysis of the ideas put forth by ancient philosophers. While the Western world underwent a “dark age” during The Middle Ages; the Islamic world experienced a remarkable and intellectually vibrant “philosophical” movement. The movement, which can be called the “Miracle of the Muslims”, holds significant prominence within universal culture, in terms of both being an inseparable part of Islamic civilization and a crucial milestone in the development of Western philosophy.
İbn Sînâ’nın Uçan Adam Nazariyesi Bağlamında Nefsin Benlik Bilinci
Authors: AZ Mehmet Ata
Published: January 2024

Modern dönemde zihin felsefesi alanında, nöro-biyoloji ve nöro-fizyolojinin verilerine bağlı olarak yapılan çalışmalarda, zihin kavramıyla bağlantılı olarak zât/benlik, şu‘ûr/bilinç ve eş-şu‘ûr bi-zât/benlik bilinci kavramları daha fazla ön plana çıkmış olsa da erken dönemden itibaren gerek İslam gerekse Batı düşüncesinde bu kavramlar kullanılmıştır. İslam düşüncesinin önemli filozoflarından İbn Sînâ, nefsin bedenden ayrı ve farklı bir mevcudiyete sahip olduğuna dair geliştirdiği düşünce deneyi Uçan Adam Nazariyesi’nde, nefs-beden ilişkisi, nefsin mâhiyeti, nefsin bedenden farklı ve bağımsız bir varlığa sahip olup olmadığı, nefsin bilince sahip olup olmadığı ve nefsin benlik bilincini nasıl ve ne zaman kazandığını ele almıştır. Farklı eserlerinde kısmi farklılıklarla ele aldığı nazariyesinde İbn Sînâ ilk aşamada, nefsin bedenden ayrı ve farklı bir mevcudiyeti ve nefsin gayri maddi bir mâhiyete sahip olduğunu temellendirmiştir. İkinci aşamada ise gayri maddi, ayrık ve farklı gerçekliğe sahip olan nefsin farklı melekelerin işlevlerini önceleyen ve bu işlevleri ‘ben’ bilinciyle birleştiren tek bir özün yani zâtın varlığını dolaylı şekilde izah etmiştir. Bununla birlikte İbn Sînâ’nın nazariyesinde asıl neyi temellendirmeyi amaçladığına dair farklı yorumlar yapılmıştır. Kimi nazariyede nefsin mâhiyeti ve gerçekliğini ele aldığını savunurken kimi de buna ek olarak nefsin benlik bilincini de temellendirdiğini savunmuştur. Bu çalışmada, İbn Sînâ’nın düşünsel deney olarak geliştirdiği uçan adam nazariyesi ele alınacaktır, nazariyenin izahına bağlı olarak nazariyenin temel amacının ne olduğu ortaya konacaktır. Daha sonra nefsin kendi zâtının şuûrunda/bilincinde olmasından kastının ne olduğu izah edilecektir. İbn Sînâ’nın şuûra ilişkin yaptığı benlik bilinci (eş-şu‘ûr bi-zât/zatî bilinç) ile bilincin bilinci (eş-şu‘ûru bi’ş-şu‘ûr) ayırımı değerlendirilecektir. Sonuç olarak da her ne kadar İbn Sînâ nazariyede öncelikli olarak nefsin bedenden ayrı ve farklı gayri maddi bir mâhiyete sahip olduğunu ele almış olsa da ikincil düzeyde nefsin kendi zâtının bilincinde olduğunu da kanıtlamayı amaçladığı temellendirilecektir.
Conceiving the Nature of Things: A Muslim Perspective
Authors: DENİZ Gürbüz
Published: January 2024

This article first aims to explain how God’s knowledge and power are revealed in the created things. It argues that since divine knowledge is infinite, the manifestation of this knowledge into existence, infinite discovery, and production in existence is possible. Indeed, limiting the manifestation of divine knowledge in existence to only one interpretation or discovery can reduce the potential for things to exist. Secondly, it attempts to prove that things are not ontologically evil, but good. Here, the attempt is based on the issue of general and specific experiences, and on the fact that reason always has the ability to overcome evil. Again, it was emphasized that the relationality of evil and the victimization and sufferings caused by the emergence of bad situations due to the conditions of time and space can be alleviated by the “belief in the hereafter” in the Islamic faith. Thirdly, it aims to briefly interpret general opinions on the nature of things in Islamic tradition. This issue is tried to be revealed with an example from history, and how those who say “things don’t have fixed and enduring nature” cause tragic consequences. The ideas that things have a fixed and permanent nature and that even seemingly extraordinary (miraculous) events can be explained within this nature are included. Finally, understanding providence is based on knowing and explaining causality in existence. The compatibility of this view with the principles of the Islamic faith is the underlying theme recurring throughout the article.
The Muslim Difference: Defining the Line between Believers and Unbelievers from Early Islam to the Present, by Youshaa Patel (New Haven: Yale University Press, 2022), 341 pages, ISBN: 978-0-300-24896-8
Authors: YILMAZ Ömer
Published: January 2024

Fulfilling the orders and prohibitions of Islam will make Muslims different. Performing ablution and praying five times a day affects the daily routine of Muslims. The fact that fasting Muslims wake up and eat at night and abstain from eating, drinking, and having sex during the day is an essential factor in the difference between Muslims and non-Muslims. For Muslims, performing the pilgrimage constitutes the pinnacle of their similarity to each other and their differentiation from members of other religions. The prohibition of waste established by Islam requires Muslims to adopt a simple lifestyle and clothing style that is away from ostentation. It primarily prevents silk clothes from being worn by men and creates a difference between cultures that use silk extensively in their clothes. When we evaluate these differences together, we can say that the difference in Islam is not a goal but a result. Commands that act on difference are not commanded to create difference. For example, fasting is effective on difference; however, commanding Muslims to fast is not to make them different from other people. The Prophet Muhammad’s approach to silk clothes is also within this framework. He said that this was the clothing of those without a share in the afterlife. The aim is not to create a difference but to prevent waste and ostentation. The difference that occurs when religious obligations are fulfilled is not abnormal. This is within the scope of freedom of belief; however, when Muslim difference is transformed from a consequence of Islamic commands and prohibitions into a direct goal, it will cause artificiality and alienation of Muslims from their society. There is no doubt that this supports Islamophobia.
Fıkıh İlmi Özelinde ve Kefevî’nin Ketâib’i Çerçevesinde Mâverâünnehir Âlimlerinin Osmanlı Ulemasına Tesiri
Authors: OKUR Kasif Hamdi , İLHAN Abdullah Sıtkı
Published: January 2024

Bu çalışmada, ilmi gelenekler içerisinde ehemmiyetli bir yer işgal eden Mâverâünnehir âlimlerinin Osmanlı uleması üzerindeki tesirlerini, fıkıh ilmi özelinde ve Kefevî’nin Ketâibu a‘lâmi’l-ahyâr min fukahâi mezhebi’n-Nu‘mâni’l-muhtâr isimli eseri çerçevesinde ele almayı hedefliyoruz. Bu tercihin sebeplerini ifade etmek gerekirse fıkıh ilmi, hukukî yapıyı belirleyen ve sosyal hayatı düzenleyen bir disiplin olması hasebiyle İslam toplumları için her zaman müstesna bir yer işgal etmiştir. Osmanlı ulemasının Hanefi fıkhını tevarüs ettikleri en önemli kaynak ise Mâverâünnehir âlimleri olmuştur. Hukukî hayatı ve toplumsal yaşamı düzenlemedeki fonksiyonu ise fıkhı, ilim geleneğinin birinci derecede iştigal alanı haline getirmiştir. Osmanlı ulemasının Hanefî mezhebine bağlı olduğu, Hanefî fıkhını da ağırlıklı olarak Mâverâünnehir ulemasına dayalı ilim silsilesi vasıtasıyla tahsil ettiği ve bu ulemanın eserlerinden faydalandığı dikkate alınırsa, aradaki ilişkiyi ortaya koymak için çalışmada neden fıkıh ilminin tercih edildiği açıklık kazanacaktır. Mâverâünnehir âlimlerinin Osmanlı uleması üzerinde fıkıh ilmi çerçevesinde yaptığı tesirin neden Kefevî’nin eseri üzerinden ele alınacağıyla alakalı olarak şu hususlar dile getirilebilir. Kefevî bu eserinde Hanefî fakîhleri Ebu Hanîfe’ye bağlayan isnad zincirine ve ‘an‘anelere yer vermiştir. Nitekim Kefevî’nin kaydettiği bu verilerden hareketle Hanefî fıkıh geleneğinin bir şeceresini çıkarmak mümkün olacaktır. Kefevî’nin çalışması yalnızca bir fakîhin hocaları, talebeleri ve eserleri ile alakalı biyografik ve bibliyografik malumat vermekle yetinmemekte, o fakîhin Ebu Hanîfe’ye kadar uzanan ilim silsilesini, dikkat çekici görüşlerini ve içinde yer aldığı önemli olayları da kaydetmek suretiyle ilmî zihniyet hakkında ayrıntılı tahliller yapmaya imkân veren bir malzeme sunmaktadır. Bu bakımdan Kefevî ve eseri, Mâverâünnehir âlimlerinin Osmanlı ulemâsı üzerine fıkıh ilmi çerçevesinde yaptığı tesiri incelemek için, isabetli bir seçim olacaktır. Bu inceleme neticesinde Hanefiliğin doktrinin ve literatürünün gelişmesinde, Mâverâünnehir bölgesinde gösterilen ilmi faaliyet oldukça etkili olduğu söylenebilir. Ayrıca Osmanlı ulemasının Hanefi fıkhını tevarüs ettikleri en önemli kaynak ise Mâverâünnehir âlimleri olmuştur. Bu intikal Mâverâünnehir âlimleri ve de literatür vasıtasıyla gerçekleşmiştir. Osmanlı medreselerinde fıkıh ilmi özelinde çoğunlukla Mâverâünnehir âlimlerinin eserleri okunmuş ve bu eserler üzerine birçok çalışma kaleme alınmıştır. Son olarak Osmanlıda fıkıh geleneğinin ana kaynağını Mâverâünnehir kökenli Hanefî âlimlerin, eserlerinin ve fıkıh anlayışlarının oluşturduğu rahatlıkla ileri sürülebilir.
Error Structure Analysis for Multiple Dual-polarization Radar using Ensemble Learning
Authors:   The Korean Data Analysis Society, d d , d d , d d , d d
Published: January 2024

Accurate quantitative precipitation estimation (QPE) was essential for the prediction and prevention of natural disasters. Recently, radar has been attracting attention as a technique for performing QPE with high spatiotemporal resolution. In particular, the QPE was improved by introducing a dual-polarization technique that observed several hydrometeorological variables at various scales compared to the single polarization radar that utilized only the existing reflectivity-precipitation relationship. This study aimed to analyze the error structure of dual-polarization radar by predicting gauged rainfall using ensemble models. The location of the radar was Gwanaksan, Garisan, and Gwangdeoksan which belonged to the Bukhan river basin. The Pearson correlation coefficients between reflectance-precipitation and gauged rainfall were examined initially. After that, each gauged rainfall was predicted using ensemble learning, which included random forest (RF), gradient boost, and XGboost. Mean absolute error, root mean squared error, and R squared were evaluated as the predictive performance. Hyper-parameters were optimized by 5-fold cross-validation, and the reliability of the research results was obtained by 10 iterations. The result showed that RF had better predictive performance than other models. Gauged stations that operated at high altitudes were not good enough for the QPE because of the mountain effect. Due to the mountain range effect, the importance of the Gwanaksan radar at an altitude of 3 km was very high.
MBTI-Based OTT Service Personalization Recommendation System Using BiVAE
Authors:   The Korean Data Analysis Society, Jeong Seyeon , Seo Young Soo , Cheon Sooyoung
Published: January 2024

The OTT platform, which provides various media contents in the modern society, seeks to improve the user experience by utilizing a personalized recommendation system. However, current recommendation systems are having difficulty in making accurate recommendations because they do not fully understand user's tendencies. This study proposes the use of a personalized recommendation algorithm using BiVAE (bilateral variational autoencoder) to solve this problem, and considers group-specific applications through MBTI. BiVAE is a probabilistic generation model that compresses and generates data considering of bidirectional information flow, providing richer expression and reconstruction capabilities by encoding and decoding in both directions. As a result of applying four types of data to the model, when applying BiVAE for each group using MBTI, the accuracy of OTT genre recommendation was shown to be superior to that of other methods. In addition, when considering MBTI, a personal recommendation using BiVAE showed higher accuracy compared to the existing recommendation system. This result means that the personalized recommendation system considering the user's personal characteristics and personality is important.
A Study on the impact of a superior's ethical leadership on employees' organizational commitment and job performance: Focusing on a 5-star hotel companies in the Busan
Authors:   The Korean Data Analysis Society, Moon Jungnam
Published: January 2024

This study was conducted to contribute to the establishment of correct ethical leadership by identifying the influence relationship between variables in the process where the ethical leadership of superiors as perceived by organizational members of a hotel company leads to organizational commitment and job performance through building organizational culture. To achieve the research purpose, 210 questionnaires were distributed to hotel employees working at 5-star hotels in Busan from September 1, 2023 to September 15, 2023, and actual analysis was conducted using the final 206 samples. For statistical analysis, IBM SPSS Ver. The 23.0 program was utilized, and the research results are as follows. First, the sub-factors that make up the superior's ethical leadership, Normative Behavior, Communication, Fairness, and Integrity, were found to have a significant positive influence on employees' organizational commitment. Second, members' organizational commitment was found to have a significant positive (+) effect on job performance. Third, the sub-factors that make up the supervisor's ethical leadership, Normative Behavior, Communication, and Integrity, were found to have a significant positive (+) effect on job performance. In the end, it can be seen that in hotel companies, if superiors adhere to organizational norms and perform normative actions such as presenting work standards, it has a positive effect on employees' job attitudes and performance. At the same time, the supervisor's sincerity and fairness, interest in organizational members, and principle-based decision-making will stimulate members' motivation for work, thereby increasing job immersion and job performance.
Effectiveness of online employment Adaptation training Program for Nursing Students
Authors:   The Korean Data Analysis Society, Yoo Je Bog , In Woo Young
Published: January 2024

This study collected data from 30 students in the 2nd, 3rd, and 4th grades of K University in J, K-do to determine the effect of online employment adaptation practice training programs on grit, career decision-making self-efficacy, and practical integration ability in the COVID-19 pandemic. An online employment adaptation practice training program was developed for nursing students based on the ADDIE model and the validity of the program was verified through expert validation, and it applied online education 10 times in real time for 4 hours a day and 5 days, using guidance from hospital education nurses and online video participation by nursing students. Descriptive statistics and regression analysis were used for the collected data. Study Results Grit (F=17.79, p<.001), practical integration capability (F=19.47, p<.001) showed a significant difference over time, with the average value of the subjects before, immediately after, and four weeks after participation in the online employment adaptation practical training program. Based on the results of this study, it is suggested the feasibility of nursing students' practice in limited remote education environment and proposed the development and application of various online employment adaptation practice training programs linked with industry collaborations for nursing students.
Factors Influencing the Quality of Life in Women Diagnosed with Cervical Cancer
Authors:   The Korean Data Analysis Society, Jun Eun-Mi
Published: January 2024

This study aimed to identify factors influencing the quality of life in women diagnosed with cervical cancer. It involved 151 women diagnosed with cervical cancer, utilizing data from the National Health and Nutrition Examination Survey spanning from 2016 to 2020. Data were analyzed using percentage, frequency analysis, average, standard deviation, t-test, ANOVA, bonferroni method, Pearson correlation coefficient and multiple linear regression analysis with SPSS/WIN 25.0. The study results revealed statistically significant differences in the quality of life based on demographic characteristics such as age (F=5.21, p=.001), marital status (F=16.56, p=.001), education level (F=4.97, p=.002), and economic activity (t=6.00, p=.015). Quality of life based on health characteristics showed statistically significant differences in walking (F=164.8, p=.001) and strength exercises (F=149.9, p=.001). The measurement results of the subjects' quality of life showed that the EQ-5D index was 0.91±0.14, subjective health status was 3.31±0.87, perceived stress level was 2.92±0.78, and body mass index was an average of 24.14±3.33 points. Quality of life was found to be significantly correlated with subjective health status (r=-0.562, p=.001) and body mass index (r=-0.174, p=.034). Variables influencing the quality of life were identified as marital status and subjective health status. Quality of life was higher in unmarried individuals and those with better subjective health status. The explanatory power of the model was 40.4%. Therefore, it is necessary to develop comprehensive and individualized nursing intervention programs.
The impact of motivation to use online badminton lesson content on perceived usefulness, acceptance attitude, and online word-of-mouth
Authors:   The Korean Data Analysis Society, Choi Sehee , Lee Seung Pil
Published: January 2024

The purpose of this study is to investigate the influence of motivation for using online badminton lesson content on perceived usefulness, acceptance attitude, and online word of mouth. For this purpose, a study was conducted on 205 adults who had experience using online badminton lesson content. The confirmatory factor analysis results showed χ ²/df=2.577, CFI=.918, TLI=.882, IFI=.920 and RMSEA=.083. As a result of the hypothesis testing, it was confirmed that information seeking and time consumption as motivation for using online badminton lesson content had a positive (+) effect on acceptance attitude and perceived usefulness, while social exchange had a negative (-) relationship. In addition, perceived usefulness showed a positive (+) relationship with online word-of-mouth and spread, and acceptance attitude showed a positive (+) relationship with acceptance of online word-of-mouth, and a significant relationship with online word-of-mouth spread. didn't In the case of online lesson content, overall positive results were confirmed when the reliability and expertise of the information provided were verified, and research in related fields should continue because the influence relationship may appear differently depending on the characteristics of the event.
Survey of High School Students’ Perception of Artificial Intelligence
Authors:   The Korean Data Analysis Society, Kwon Danam , Hur Nawon , Kang Ju Hyun
Published: January 2024

In this study, we aimed to understand how high school students perceive artificial intelligence (AI) in the context of the influence of AI. We sought to identify what is necessary for the proper implementation of AI education. To achieve this, the study conducted surveys targeting students from five high schools in Region B. The surveys covered their understanding and awareness of AI, perceptions of AI learning, awareness of AI applications, and recognition of the role of AI. A total of 272 respondents were analyzed. Survey results revealed that high school students generally recognized the importance of AI in their lives, however, their interest in learning about AI was relatively low. While there was a high perceived need for education on creating AI application content, there was a negative perception towards utilizing AI in career choices. Although AI was perceived as necessary and having a positive impact on human life, some negative perceptions emerged regarding its influence on human employment. Ultimately, high school students considered their understanding of AI to be at a moderate level, but negative aspects were revealed concerning learning and career choices. This means that education on AI has not been properly integrated, the context of exam-focused school systems. Therefore, it is suggested that educational activities incorporating AI in school curricula as well as providing meaning to AI in career exploration education.
ANALISIS KELAYAKAN USAHATANI JAGUNG DI KECAMATAN BULANGO UTARA KABUPATEN BONE BOLANGO PROVINSI GORONTALO
Authors: Mokolinug Savira , Canon Syarwani , Payu Boby Rantow
Published: January 2024

Penelitian ini bertujuan untuk mengetahui status keadaan sosial ekonomi petani jagung di kecamatan Bulango Utara kabupaten Bone Bolango provinsi Gorontalo dan kelayakan usahatani jagung di kecamatan Bulango utara kabupaten Bone Bolango provinsi Gorontalo untuk sekali panen. Penelitian ini dilakukan pada bulan Oktober 2022. Data yang digunakan bersumber dari hasil Kuesioner dan wawancara pada penduduk Kecamatan Bulango Utara yang bermata pencarian sebagai petani jagung. Metode yang digunakan untuk mengetahui kelayakan usahatani adalah R/C Rasio. Hasil Penelitian menunjukkan bahwa 1) Para responden termasuk pada kelas sosial ekonomi menengah kebawah karena rata-rata memiliki lahan sendiri namun hasil panen tidak menentu sehingga pendapatan tidak menentu, pendidikan pun masih tergolong rendah dan rata-rata penghasilan utama adalah petani jagung tapi memiliki keadaan rumah layak huni. 2) R/C Rasio yang di dapat adalah 1,6 maka usahatani di Kecamatan Bulango Utara dapat dikatakan layak karena lebih dari 1.
Precision Personalized Medicine of Strategic Health Action in Niemann-Pick Disease type A/B
Authors: Sánchez-Vargas Juan Manuel , Moreno Giraldo Lina Johanna
Published: January 2024

Introduction: Niemann-Pick A and B diseases (NPD), are part of the group of lysosomal storage diseases caused by acid sphingomyelinase (ASM) deficiency, which catalyzes the hydrolysis of sphingomyelin (SM) to ceramide and phosphocholine. As a result, SM and its precursor lipids accumulate in lysosomes in cells of the reticuloendothelial system, leading to loss of the ability to degrade macromolecules, forming intracellular inclusions that are deposited in organs. NPD-A/B are caused by deleterious variants in the sphingomyelin phosphodiesterase 1 (SMPD1) gene, leading to defective formation of this enzyme and preventing the movement of lipids out of the cells.
Case report: 20-month-old infant with neurodevelopmental delay, malnutrition, dysmorphic facies and hepatosplenomegaly. The initial approach ruled out infectious and lymphoproliferative diseases. A targeted clinical exome was performed which showed two variants of the SMPD1 gene (compound heterozygous), one of pathogenic clinical significance and the other probably pathogenic. In the enzymatic activity, it was found increased biomarker lyso-SM-509 and decreased ASM activity, with which phenotype-genotype correlation with NPD-A/B is performed.
Discussion and Conclusion: With a defined and precise diagnosis it is possible to guide health actions, follow-up guidelines, risk assessment of the inheritance model through an index case in order to find possible carriers, perform a complete genetic counseling, implement and initiate targeted treatments to reduce morbidity and mortality associated with this pathology.
Unlocking the Molecular Secrets: The Transformative Role of Genetic Insights in Modern Medicine
Authors: Mendez-Rios Jorge David
Published: January 2024

In this editorial, we explore the pivotal role of genetics in revolutionizing modern medicine. The journey begins with genetics as the cornerstone of pathophysiology, where a shift from symptom-centric approaches to genetics-centric understanding guides precise diagnostics and targeted therapeutics. The advent of precision medicine marks a transformative era, tailoring treatments to individual genetic profiles. Advanced research methodologies uncover new gene associations, expanding our knowledge and offering novel therapeutic avenues. The focus on RNA expression adds richness to our comprehension of genetic regulation, with transcriptomics decoding the intricate language of genes. This renaissance in molecular genetics promises to reshape healthcare, offering accurate diagnostics, targeted therapies, and improved patient outcomes. As we navigate this complex landscape, the editorial concludes by highlighting the ongoing efforts and dedication of the scientific community, expressing anticipation for future discoveries that will shape the next chapters of medical progress.
First report of SAVI syndrome in Panama due to a variant of the STING1 gene in patient with emphysema and idiopathic pulmonary fibrosis
Authors: Austin-Ward Enrique Daniel , Brid Edgardo
Published: January 2024

Introduction: The STING gene (Stimulator of Interferon Genes) emerges as a key element in the understanding and management of hyperinflammation and autoimmune conditions. Case: We report an adolescent patient with a history of asthma since early childhood, who after a SARS-CoV-2 infection, presented an exacerbation of respiratory symptoms, detecting emphysema, bronchiectasis and pulmonary fibrosis and in whom a pathogenic variant with gain of function of the STING gene was detected, allowing the diagnosis of SAVI (Sting-Associated Vasculopathy with onset in Infancy), which is the first case reported in Panama. Conclusions: JAK protein inhibitors and other innovative strategies constitute a therapeutic option in these cases, as well as other innovative strategies still under development, in which interferon inhibitors such as Zeatin, a cytokinin present in plants, as well as other natural products, may play a role.
Mother Genetics
Authors: Austin-Ward Enrique Daniel
Published: January 2024

While I was thinking about how to write this brief article, I was looking for the most appropriate sequence of arguments to make my way to justification and acceptance in the consciences, but I ended up deciding to go to the point and simply say: "everything starts from Genetics". And, "Genetics is at the starting point of all intelligent and well-reasoned clinical practice" .... or at least, it should be. And I am convinced that it certainly will be. Although this is not a need for affirmation and self-convincement, and a statement of this caliber might at first be misplaced because of its possible self-centeredness and apparent lack of humility, nothing could be further from our real intention.
The purpose of this paper is to show that we have been witnessing, for a couple of decades now, an unavoidable and urgent paradigm shift in the understanding of the health-disease balance, and that this is not an arbitrary statement, but is based on the robust logic of the literature and scientific evidence. Therefore, this paradigm shift requires special attention so that changes in the understanding of the origin of diseases occur more effectively, as we know that modern science advances rapidly, testing our ability to adapt quickly to all these changes. Along with technical changes, which are the easiest to perceive, there are changes in paradigms or models of thought, which often occur more silently and require changes in health care structures and models that are more difficult to implement, due to the complexity of daily life, and the need for re-education. This means that changes in habits and ways of thinking are required.
Aspectos clínicos epidemiológicos y sociodemográficos de las pacientes con morbilidad extremadamente grave
Authors: Cano Díaz Mariela , Espinal Cepeda Yomeris Margarita , Batista Rojas Osvaldo
Published: January 2024

Introducción: El estudio de la morbilidad materna extremadamente grave se considera como clave imprescindible para avanzar no sólo en el conocimiento para el desarrollo del cuidado obstétrico. Objetivo: Caracterizar la morbilidad materna extremadamente grave en el Hospital Gineco-obstétrico “Eusebio Hernández”. Diseño metodológico: Se realizó un estudio descriptivo de corte transversal en el período comprendido de 2019 al 2021. Se trabajó con todo el universo: 91 gestantes diagnosticadas. Resultados: El mayor grupo fue el de las 24 a 35 años con un total de 91 pacientes. La mayoría eran hipertensas, y el principal factor de riesgo fue la infección vaginal. Conclusiones: Según el criterio de enfermedad específica, predominaron las pacientes con hemorragia y el manejo instaurado que más se realizó fue la realización de histerectomía por emergencia.
Infección por Virus del Papiloma Humano en mujeres con citología negativas
Authors: Gutierrez Machado Mario , Suárez González Juan Antonio
Published: January 2024

Introducción: La infección genital por el PVH es la ITS más frecuente. Objetivos: Describir los resultados de la atención a mujeres con citologías negativas y positividad en test de PVH. Método: Estudio analítico longitudinal en el Hospital Gineco obstétrico Docente Mariana Grajales desde 2019 hasta 2021. Constituida la muestra por 174 mujeres. Se crearon tablas de distribución de frecuencias con valores absolutos (número de casos) y relativos (por cientos). Se determinó la media, mediana, moda, mínimo y máximo. Desde el punto de vista inferencial se aplicó la prueba de Chi cuadrado para bondad de ajuste. Resultados: En 8 mujeres se encontraron más de una cepa 4,44%. Acuden a seguimiento 174 mujeres 96,66% del total. Se encuentran entre los 31 a 40 años 54,02%. Iniciaron las relaciones sexuales antes de los 20 años el 94%, con una media de 16,8 años. El 37,35% ha tenido más de 5 parejas sexuales. Refirieron sangramiento intermenstrual el 74,71%. A la totalidad de las mujeres se les realizo colposcopia y en el 54,59% se encontraron hallazgos. En los estudios de citología y cepillados resultaron positivos en 29 mujeres: 16,66% se diagnosticaron LIEBG y en el 12,66% ASCUS. En 15 mujeres se diagnosticaron LIEAG. Se les realizo conización por ASA diatérmica a 82 mujeres 47,12%. De las 128 mujeres con pull positivo a otros PVH el 55,17% tiene sangramiento intermenstrual. De las 46 mujeres con colposcopia de alto grado se confirmaron en 43 para una correlación positiva del 93,4% y de las 49 mujeres con colposcopia de bajo grado en 39 para un 79,5%. Conclusiones: la mayoría de las mujeres tienen entre 31 y 40 años, con inicio de las relaciones sexuales antes de los 20 años, refieren varias parejas sexuales, el principal síntoma referido es el sangramiento intermenstrual. Se realizó colposcopia a todas las mujeres y conización por ASA diatérmica a casi la mitad de la muestra. Se comprobó correlación positiva colpo histológica en la mayoría de los casos fundamentalmente en el alto grado.
Síndrome de Asia: revisión sistemática de literatura
Authors: Márquez Castañeda Yuly Andrea , Bonilla Sepúlveda Oscar Alejandro , Márquez Diana Valentina
Published: January 2024

Ha habido muchos casos de aparición de autoanticuerpos y síntomas de enfermedad después de la exposición a adyuvantes, no solo después del aumento de senos con implantes de silicona, sino también como un efecto secundario muy raro de la vacunación, como el síndrome de la guerra del Golfo o el síndrome de miofascitis macrofágica. Las enfermedades cuyos síntomas se desarrollaron después de dicha exposición adyuvante se denominan síndrome autoinmune/inflamatorio inducido por adyuvantes (ASIA). El grupo de adyuvantes incluye no solo implantes de silicona, sílice, escualeno y aluminio, sino también componentes de tinta utilizados para hacer tatuajes. Analizando los informes disponibles sobre la influencia de los adyuvantes en el desarrollo de enfermedades autoinmunes, se concluye que, además de la exposición prolongada a la silicona, también es necesaria la coexistencia de otros factores, como genéticos o ambientales. Los análisis claramente no confirman un mayor riesgo de desarrollar una enfermedad autoinmune después del aumento de senos con implantes de silicona o tatuajes, pero parece que entre estas pacientes hay un grupo que está más predestinado a desarrollar síntomas de la enfermedad. En la población general, los beneficios de la vacunación son obvios, y el riesgo de eventos adversos graves después de la inmunización es incomparablemente menor que el riesgo de desarrollar una enfermedad específica y sus complicaciones, también para pacientes con enfermedades autoinmunes diagnosticadas. Debido a la heterogeneidad de los datos en estudios previos y las dificultades para diagnosticar ASIA, parece necesario realizar más análisis de la influencia de los adyuvantes en el desarrollo de enfermedades autoinmunes y refinar los criterios de diagnóstico de ASIA, que ahora permiten un diagnóstico demasiado fácil de esta enfermedad.
Abordaje diagnóstico y terapéutico de la mastalgia. Un reto cotidiano en la consulta ginecológica.
Authors: Sanabria Villegas Luz del Carmen , Santiago Sanabria Leopoldo , Villafán Athié Mario , Van Tienhoven Ximena , Rodríguez Castro Renata Fernanda , De la Puente Gómez Ariel Zoilo
Published: January 2024

La mastalgia es uno de los principales motivos de consulta diaria para el ginecólogo. Se estima que alrededor del 70% de las mujeres experimentará mastalgia en algún momento de su vida, además que es un síntoma que puede presentarse de manera reincidente. Es un cuadro que suele representar gran angustia en la paciente dada la posible asociación con algún proceso maligno, lo cual se ha demostrado que tan solo ocurre hasta en el 3% de los casos, por lo que se debe tranquilizarla durante la consulta de primer contacto. Se trata de un síntoma con múltiples etiologías, que en la mayoría de los casos se deben a patologías benignas de la glándula mamaria. La evaluación por estudios de imagen debe apegarse a las recomendaciones emitidas por las diferentes guías internacionales y no solicitar estudios innecesarios que lleven a un sobrediagnóstico y sobretratamiento. El abordaje en el tratamiento puede representar un gran reto para el ginecólogo, ya que existen diversas opciones que abarcan desde terapéuticas no farmacológicas, como son modificaciones en el estilo de vida y múltiples terapéuticas farmacológicas, sin embargo, existen pocos ensayos clínicos aleatorizados que permitan demostrar la superioridad de uno. En objetivo del presente es revisar las diversas recomendaciones en el abordaje diagnóstico y tratamiento que sustentan el manejo clínico de la mastalgia.
Del Impacto de las Investigaciones
Authors: Reyes Osvaldo
Published: January 2024

Cuando un investigador se plantea esa primera pregunta que se convertirá en un protocolo, no sabe lo que se encontrará al final del camino. Puede tener una hipótesis de trabajo, pero la realidad es que el mundo real es muy peculiar y las respuestas obtenidas pueden no ser las esperadas. Sin embargo, ese es el propósito de cualquier investigación: llegar a un descubrimiento, sin olvidar que trabajamos con probabilidades y no con verdades absolutas.

Lo que fallamos en contemplar es que esta cadena de procesos y decisiones van más allá de la sección “Resultados” del artículo que esperamos escribir. Una vez plasmamos en papel el fruto de nuestro trabajo, lo estamos convirtiendo en un material de uso global y el mismo puede ser utilizado de muchas formas. Puede ser aprovechado por miembros del personal de salud en el manejo de sus pacientes o servir de elemento educativo en programas de residencia de todo el mundo. En ambos escenarios vemos una arista de las repercusiones y del alcance que tiene el esfuerzo emprendido al iniciar un proyecto de investigación.

Sage Policy Profiles es parte de la red Social Science Space y publicaron hace poco una herramienta de gran utilidad (https://policyprofiles.sagepub.com) que puede ser usada para responder esa interrogante. Permite buscar los artículos de un investigador y determinar en qué documentos de políticas públicas se han mencionado los mismos. Este simple ejercicio les abrirá los ojos al mostrarles el inmenso alcance que tienes sus estudios y, a la vez, funciona como un recordatorio de la importancia de ejecutar sus protocolos de la mejor manera posible.

Lo que se publica no es un grupo de páginas llenas de letras. Es un conocimiento destilado, plasmado para ayudar en el progreso de la ciencia. Como tal, no se quedará en la institución en la que labora. Se esparcirá por el mundo, atravesando fronteras y modificando la atención de personas que nunca conocerán su nombre.

Cambiemos el mundo un artículo a la vez.
Melanoma de Vulva. Reporte de un Caso
Authors: Jimenez Hiciano Juan Jose , Lasso de la Vega Zavala Jorge
Published: January 2024

El cáncer de vulva representa solo el 1% de los canceres en las mujeres, siendo el melanoma maligno el menos frecuente dentro de este tipo de cáncer. Se presenta en mujeres de edad avanzada. Su manejo es principalmente quirúrgico y tiene una elevada mortalidad principalmente por enfermedad metastásica. Presentamos el caso de una mujer que llegó con una masa en los labios mayores y fue diagnosticada como melanoma maligno vulvar, tratada con cirugía y radioterapia de forma oportuna, pero que presenta metástasis pulmonar, quien recibe actualmente tratamiento para esto.
Angiomiolipomas gigantes en paciente con esclerosis tuberosa conocida: Presentación de un caso
Authors: Reyna Rolando , Hortal-Gasull Isabella
Published: January 2024

Paciente femenina de 33 años con antecedente de esclerosis tuberosa diagnosticada a los 3 años de edad, acude al cuarto de urgencias por hematuria, distensión y dolor abdominal intenso de predominio izquierdo. Entre los estudios previos observados en el archivo digital contamos con ultrasonido abdominal de hace 10 años, que reportó innumerables lesiones redondas e hiperecogénicas en relación con angiomiolipomas menores de 4.0 cm. Fue evaluada por el servicio de urología que evidencia abdomen blando, distendido y masa abdominal de consistencia sólida, probablemente secundaria a tumoración renal, por lo que solicitan estudios tomográficos que reportan angiomiolipomas gigantes en ambos riñones, con posterior hematoma retroperitoneal, sin datos de sangrado activo.
Estrés laboral y sus efectos en la salud mental: a propósito de un caso
Authors: Cedeño Caballero Neyra
Published: January 2024

Introducción: De acuerdo con la Organización Mundial de la Salud , el estrés laboral es identificado como un grupo de reacciones emocionales, psicológicas, cognitivas y conductuales ante exigencias profesionales que sobrepasan los conocimientos y habilidades del trabajador para desempeñarse de forma óptima. Caso clínico: Se presenta el caso de una femenina de 50 años de edad a la cual se le da manejo y seguimiento en sala de psiquiatría en septiembre de 2022 por envenenamiento intencionalmente auto- inflingido con antidepresivos tricíclicos debido a constantes preocupaciones sobre problemas económicos , conflictos laborales frecuentes y conflictos familiares. Inicialmente es manejada a su ingreso a la institución por el servicio de urgencias médicas con soporte respiratorio, debido a deterioro neurológico además de presentar arritmia cardiaca producto de la intoxicación con antidepresivos tricíclicos , requiere manejo en sala critica de urgencias donde posteriormente es transferida al servicio de medicina interna para estudios más específicos y descartar afección cardiaca. Una vez se descarta la misma se transfiere para manejo y estudio por salud mental. Conclusión: El estrés laboral es una patología conocida , pero en su mayoría con un subregistro importante, y que en muchas ocasiones lo vemos en estadísticas finales de mortalidad con una elevada tasa de suicidios por lo que es importante velar que el trabajador desarrolle su labor en un entorno laboral saludable , mejorando así la productividad laboral , disminución del ausentismo laboral y gastos económicos directos producto de incapacidades constantes por distintos trastornos antes mencionado.
Evaluación y tratamiento del trastorno motor en niños con parálisis cerebral: perspectiva neuroquirúrgica
Authors: Morales V Stephany
Published: January 2024

La parálisis cerebral (CP, por sus siglas en inglés) es un trastorno crónico resultado del desarrollo anormal del cerebro que causa una variedad de trastornos permanentes del movimiento y del tono postural. Los síntomas pueden variar según el tipo de trastornos motores que se presenten y, a menudo, resultan en limitaciones en la actividad y dependencia total de los cuidadores. Aunque la CP se diagnostica clínicamente, la tecnología permite dividir los resultados de la resonancia magnética en niños con CP en cinco grupos según el sistema de clasificaciónn de imágenes por resonancia magnética para una mejor comprensión de la afección cerebral. El tratamiento es altamente complejo y requiere un manejo multidisciplinario para asegurar la mejor calidad de vida posible. Las técnicas neuroquirúrgicas pueden ser parte del plan de tratamiento para mejorar la calidad de vida del niño y su familia.
Apendagitis epiploica. Reporte de un caso
Authors: Auon Naila , Reyna Rolando
Published: January 2024

Paciente masculino de 39 años con antecedente de meningioma atípico operado, en la actualidad en tratamiento con radioterapia. Admitido a cuarto de urgencia con cuadro clínico de 3 días de evolución caracterizado por dolor abdominal localizado en hemiabdomen izquierdo, el cual se irradia a miembro inferior izquierdo, asociado a fiebre no cuantificada. Al examen físico, el abdomen es blando, depresible, con dolor en fosa ilíaca izquierda. Se le realiza radiografía de abdomen simple donde no se visualiza patrón obstructivo intestinal ni otros hallazgos patológicos. Es evaluado por el servicio de Cirugía General, quien solicita realizar tomografía de abdomen y pelvis contrastada (TC) para descartar diverticulitis aguda. La tomografía contrastada, muestra en el aspecto anterior de la pared del tercio proximal del colon sigmoide una imagen ovoidea con densidad grasa, rodeado por un anillo hiperdenso delgado, asociado a marcada estriación localizada de la grasa pericolónica y engrosamiento de las fascias peritoneal parietal y transversalis en relación con proceso tipo   apendagitis epiploica aguda. El paciente se le da tratamiento sintomático con mejoría del cuadro y egreso con analgésicos y antiinflamatorios orales.
Luxación expuesta del tobillo sin fractura: Reporte de caso con seguimiento de 1 año
Authors: Alemán Arjona Gustavo Adolfo
Published: January 2024

Introducción/Presentación del caso: Se reporta un caso particular de luxación expuesta de tobillo sin fractura maleolar asociada luego de un accidente vehicular (traumatismo de alta energía), junto con el desbridamiento inicial, la reducción y el uso de un fijador externo. Durante la evaluación se encontró una deficiencia de cobertura de tejidos blandos, que originalmente se abordó con terapia de presión negativa antes de recibir el autoinjerto de piel. Creemos que es vital compartir nuestra experiencia, evolución positiva tras un año de seguimiento, con mejoría en la EVA y la puntuación de la FAOS, y proporcionar posibles opciones de tratamiento en la literatura debido a la rareza de este tipo de luxación expuesta sin fractura. Conclusiones: Las principales conclusiones son la pronta administración de antibióticos intravenosos, el desbridamiento y la reducción, la técnica de estabilización externa, el cuidado suficiente de los tejidos blandos y la pronta cobertura de los defectos de la piel.
Banco de donantes voluntarios de células progenitoras hematopoyéticas. Proyecto Panama Dono
Authors: Vernaza-Kwiers Alejandro , Blake Elena , Gutiérrez Yina , Moscoso Juan , Ortiz Luis , Cuero Cesar , Cedeño Diana , Rodríguez Hilze
Published: January 2024

Introducción; El Trasplante de Células Progenitoras Hematopoyéticas es actualmente un tratamiento para diferentes desordenes hematológicos malignos y no malignos, que se efectúa cuando existe un receptor con un donante idéntico o haploidéntico para los genes del Complejo Mayor de Histocompatibilidad. En ausencia de donante familiar compatible, hemos creado el Programa de Donantes Voluntarios con tipificación del Sistema HLA. que han expresado su consentimiento de ser donantes y comparten los alelos del Sistema de linfocitos humanos codificados en el brazo corto del cromosoma seis. Materiales y métodos: El presente estudio es un estudio descriptivo, observacional y transversal que presenta los resultados de la búsqueda de donantes voluntarios para receptores sin donante familiar en el Programa Panamá Dono y su aplicación en Panamá. Resultado: De los grupos familiares estudiados que incluye receptor y donantes familiares, un total de 783 personas estudiadas aceptaron voluntariamente ser donantes no relacionados y sus tipificaciones HLA incorporadas al Programa Panamá Dono. Un total de 321 pacientes sin donante idéntico o haploidentico en su grupo familiar, se les ha buscado donante no relacionado en el Programa y se logró Trasplantar el primer receptor con un donante voluntario compatible en 16 genes del Complejo Mayor de Histocompatibilidad en el Hospital del Niño. Conclusión: El Laboratorio Nacional de Trasplante de la Caja de Seguro Social ha logrado crear el Programa de Donantes Voluntarios de Células Progenitoras Hematopoyéticas denominado PANAMA DONO, que consta de 788 panameños que han expresado su consentimiento. En la actualidad una paciente del Hospital del Niño fue trasplantada en 2022 con esta modalidad de donante compatible no relacionado. La compatibilidad idéntica de la receptora con el donante voluntario fue de 16 alelos idénticos del Complejo Mayor de Histocompatibilidad.