bluuebunny/crossref_metadata_2025 huggingface dataset:
ІНВЕСТИЦІЙНА ФУНКЦІЯ КАПІТАЛУ ТА ЇЇ ОБЛІКОВО-ІНФОРМАЦІЙНЕ ЗАБЕЗПЕЧЕННЯ
Authors: V. S. Rudnytskyi  , V. A. Derii  , Ya. D. Krupka
Published: March 2020

Розглядаються основні теорії капіталу, їхня інтерпретація, проблеми реалізації в системі обліку, подання у балансі та іншій фінансовій звітності. Капітал визнано як основну економічну категорію, важливий об’єкт обліку та критерій оцінювання ефективності діяльності підприємства.

Визначено, що капітал є своєрідною інвестицією власників у діяльність та розвиток підприємства. Окрім традиційних підходів до трактування капіталу (як засобів виробництва, як майна та власності підприємства, як джерела формування майна), виокремлено також його інвестиційну функцію. Розглядаючи капітал з позиції обліку і балансу, досліджено його інвестиційні властивості, що вирізняють його серед інших джерел забезпечення господарської діяльності підприємства. Трактується кругообіг капіталу з позиції капіталізації витрат. Обґрунтовано вплив на результати діяльності підприємства, величину його капіталу, способів і термінів капіталізації, рекапіталізації, декапіталізації витрат.

Діяльність підприємства, як динамічний процес, розглядається через призму взаємопов’язаних ланок єдиного циклу. Вона прирівнюється до реалізації цілісного інвестиційного проєкту. Сформований засновниками власний капітал, а також запозичені зі сторони фінансові ресурси вкладають в об’єкти інвестування і на основі створеного економічного потенціалу здійснюється операційна діяльність. Її результатом є одержання прибутку, який служить джерелом для повернення інвесторам вкладеного капіталу через дивіденди, відсотки або повторно спрямовується на розширення бізнесу.

Надано пропозиції щодо розширення інформативності фінансової звітності стосовно капіталу з позиції його участі в інвестуванні, формування доходів, витрат і фінансових результатів від інвестиційної діяльності підприємства.
THE STATE CREDITE ON UKRAINIAN LANDS AT THE END OF ХVIII — AT THE BEGINNING OF ХХ CENTURIES: THE HISTORY AND LEGAL CHARACTERISTICS
Authors: O. M. Holovko  , V. A. Grechenko  , O. V. Holovko
Published: March 2020

The article deals with the historical and legal analysis of the formation and development of the state credit system in the Ukrainian lands. The article outlines the conditions and circumstances under which the organizational and legal foundations of the credit activity of banking and other state institutions were formed. During the incorporation of Ukraine into the Russian Empire, the elimination of Ukrainian statehood, and the encroachment upon the very cultural and national identity of the Ukrainians, the system of state credit actually did not exist. The attempts to create banking institutions were unsuccessful because there was niether any market formed nor money and securities in the feudal serfdom empire.

The changes only took place in the course of capitalist modernization in the second half of the nineteenth century. The abolition of serfdom made available a large number of workers and the legislator faced the urgent task of creating legal foundations for the development of the credit market. The main reform was the creation of the State Bank in 1860, which, in addition to regulating money market, emission activities, made long-term loans. It was guided by the statutory statute, other regulatory legal acts. In order to promote the credit in the sphere of agriculture, in particular mortgage, the Peasant Land Bank and the State Noble Land Bank were established, which got advantages together with privately owned entities. The offices, branches and agencies of the State Bank and the branches of State Land Banks were directly active in Ukrainian provinces Their activity (and, accordingly, its legal regulation) was under the influenc of the specific features of Ukraine’s financial and economic development, namely, a much more higher pace of industrial and agricultural development than in other regions of the Russian empire. But the insufficient development of long-term crediing in Ukraine had the negative impact on that development.
FORMATION OF PSYCHOLOGICAL PECULIARITIES OF TIME-MANAGEMENT OF A MODERN EXPERT IN THE FIELD OF FINANCE
Authors: U. Huzar  , O. Zavydivska  , V. Kholyavka  , M. Kryshtanovych
Published: March 2020

The article generalizes the psychological peculiarities of time-management of financial experts within the framework of modern understanding of time-management problems. The aim of this research is to substantiate psychological aspects of time-management of a modern expert in the field of finance and their manifestation in theory and practice. The relevance of this research is characterized by the fact that most top-managers haven’t enough organizational skills, compulsory, can’t rationally use personal and working time and aren’t aware in psychological aspects of time-management. The types of time-management are analyzed in the article; the practical characteristics of each type are presented. It is determined that every type of time-management for the employees of financial institutions is quite different and requires the using of special forms of work such as diagnosis, activity analysis, designing, individual counseling, individual or group training, and, accordingly, the using of specialized time-management techniques. The notion of «self-motivation of employees» is characterized: authors propose to consider it more as a vital position, rather than as a managerial characteristic. The article presents methods of self-motivation, which have a positive effect on most people. The modern typology of personality depending on the type of self-motivation including the individual approach to a person is presented: purposeful type, gambling type, hardworking type and creative type.

The authors give clear symptomatic of the «burnout syndrome», its prevention and practical advice on combating the personnel «burnout» in the company. The conducted research helps to answer on many questions in time-management and personnel management spheres. The classification of time-management and its practical manifestation will help to choose the correctly type of time-management and apply it, effectively use the provided recommendations. The proposed methods of self-motivation, typology of personality will contribute to the formation of a new human behavior and additional motivation in financial sphere and in personal life too.
Perfil sociodemográfico, morbidades referidas, bem-estar e trabalho remunerado de mulheres: estudo populacional
Authors: Emílio Marina Mendonça , Lima Jéssica Carvalho , Coelho Vitoria Helena Maciel , Martins Lislei Jorge Patrizzi , Castro Shamyr Sulyvan de , Walsh Isabel Aparecida Porcatti de
Published: March 2020

Estudo transversal de base populacional, realizado em 2014, cujo objetivo foi verificar as associações entre o perfil sociodemográfico, morbidades referidas, indicadores de bem estar e trabalho remunerado, analisando dados do Inquérito de Saúde da Mulher da cidade de Uberaba/MG. As características sociodemográficas foram autorrelatadas. As morbidades referidas foram avaliadas por meio de autorrelato, a partir de uma lista baseada no questionário Índice de Capacidade para o Trabalho e os indicadores de bem estar por meio de algumas questões do Questionário WHOQOL- bref, da Escala de Escala de Rastreamento Populacional de Depressão e do Self-Report Questionnaire. Participaram 1.483 mulheres (533 com e 950 sem trabalho remunerado). Das mulheres que não exerciam trabalho remunerado, 41,9% estava na faixa estaria de 60 anos ou mais, 51,26% em união estável, apresentaram média de escolaridade de 7,76 (±5,23) anos e de renda per capita de 815,98 (±1082,75) reais.  A maioria das que exerciam trabalho remunerado (54,6%), estava na faixa etária de 35-59 anos e 303 (56,85%) não estava em união estável, com média de escolaridade de 9,17(±4,90) anos e renda per capita de 788,55 (±766,69) reais. Houve diferenças significativas entre os grupos, indicando mulheres sem união estável e maior escolaridade exercendo trabalho remunerado. As morbidades mais relatadas por todas as mulheres foram as respiratórias, endócrinas/metabólicas e genitourinárias. As que exerciam trabalho remunerado estavam significativamente satisfeitas/muita Satisfeitas com o desempenho das atividades do dia a dia, relataram nada/muito pouco impedimento para realizar atividades devido a dor. Houve maior comprometimento para as donas de casa com relação sentir-se nervosa/tensa/preocupada, cansar com facilidade e apresentar esforço para realizar tarefas habituais.
Perfil epidemiológico de Mães trabalhadoras
Authors: Salum Edneia De Oliveira , Lima Jéssica Carvalho , Marcacine Patrícia Ribeiro , Walsh Henrique Porcatti , Castro Shamyr Sulyvan de , Walsh Isabel Aparecida Porcatti de
Published: March 2020

Este é um estudo transversal, parte do Inquérito de Saúde da Mulher, realizado em 2014 com o objetivo de analisar o perfil epidemiológico de mães trabalhadoras da zona urbana do município de Uberaba-Minas Gerais. Para os dados, considerou-se o autorrelato. Participaram 454 mulheres, com média de idade de 45,38±12,84 anos, a maioria trabalhadora informal/autônoma, com 2,64±1,48 filhos. Houve associação entre maior média de idade com maior número de filhos e maior número de partos normais. Quanto menor a renda e a escolaridade, maior o número de filhos e de partos normais. As não brancas tiveram mais partos normais. Quanto às características do trabalho, as autônomas/por conta-própria tiveram maior número de filhos que as empregadas/assalariadas. Houve alto número de relatos de depressão pós-parto, que foi associada ao maior número de filhos.
Sintomas musculoesqueléticos e características sociodemográficas em mulheres
Authors: Marcacine Patrícia Ribeiro , Emílio Marina Mendonça , Lima Jéssica Carvalho , Oliveira Renata Martins Matos , Castro Shamyr Sulyvan de , Walsh Isabel Aparecida Porcatti de
Published: March 2020

Este é um estudo quantitativo realizado em 2014 com 1.486 mulheres e com o objetivo de investigar os sintomas musculoesquelético e sua associação com as características sociodemográficas em mulheres. Foram analisadas características sociodemográficas, presença de síndrome musculoesquelética, limitações nas atividades e necessidade de consultas a profissional de saúde devido aos mesmos. Foi identificado que 62,45% das mulheres relatou a síndrome musculoesquelética em pelo menos uma região do corpo. No entanto, 73,69% não apresentou limitações nas atividades e 66,35% não consultou profissional da saúde em função. Maior número de regiões com sintomas, limitações e consulta a profissional foi observado nas mais jovens e que não tinham união estável. A alta prevalência de síndrome musculoesquelética em mulheres é um desafio ao o sistema público de saúde.
PhD Theses by Faroese scientists or on Faroese subjects defended in 2019
Authors: Editor E.
Published: March 2020

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Macro-Trends in Brazilian Environmental Education: Some reflections based on Morin’s Theory of Complexity
Authors: Antonio Juliana Mara , Massaê Kataoka Adriana , Neumann Patrícia
Published: March 2020

Environmental Education in Brazil is a multi, inter and transdisciplinary field of knowledge. It presents different trends that change according to focus and speeches based on different epistemologies. There are different ways to concept and to practice Environmental Education on three macro-trends related to political pedagogical models: Conservative, Pragmatic and Critical. Then the objective of this paper is to think about macro-trends in Environmental Education since Complexity perspective. For it, we present the history of Environmental Education in Brazil, after three macro-trends and their more and less highlighted characteristics and finally we think about it. Environmental Education under Complexity perspective pays attention especially to socioenvironmental problems that incorporate multiple properties of reality and it allows to integrate characteristics of macro-tends that are fragmented.
Alopesi areatalı hastalarda serum bilirubin, ürik asit ve albumin düzeyleri
Authors: ALTUNIŞIK Nihal , TÜRKMEN Dursun
Published: March 2020

Amaç: Alopesi areata (AA), saçlı deride skar bırakmayan kıl kaybı ile karakterize, inflamatuar bir hastalıktır. Son dönemlerde inflamatuar ve otoimmun hastalıkların patogenezinde düşük antioksidan düzeyleri ve oksidatif stresin rol oynadığını gösteren çalışmalar bulunmaktadır. Çalışmadaki amacımız, vücuttaki antioksidan durumu yansıtan serum bilirubin, albümin (Alb) ve ürik asit (ÜA) düzeylerinin alopesi areata etiyopatogenezinde rolünü değerlendirmektir.
Gereç ve Yöntem: Çalışmaya dermatoloji kliniğine başvuran 62 AA hastası ile yaş ve cinsiyet olarak benzer 61 sağlıklı kontrol grubu alındı. Her iki grupta, serum total bilirubin (Tbil), direkt bilirubin (Dbil), indirekt bilirubin (İbil), ÜA ve Alb düzeyleri ölçüldü.
Bulgular: Çalışmaya 62 alopesi areata hastası (50 erkek, 12 kadın) ve 61 kontrol hastası (48 erkek, 13 kadın) dahil edildi. İki grup arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı bir fark yoktu. Alopesi areatalı hastalarda serum Tbil, İbil, ÜA ve Alb değerleri kontrol grubuna göre daha düşüktü, fakat istatistiksel olarak anlamlı bir fark yoktu.
Sonuç: Alopesi areatalı hastalarda serum Tbil, İbil, ÜA ve Alb değerlerinin kontrol grubuna göre daha düşük olması bize vücuttaki antioksidan durumu yansıtan serum bilirubin, albümin ve ürik asit düzeylerinin alopesi areata etiyopatogenezinde rolü olabileceğini düşündürmektedir. Bununla birlikte istatistiksel olarak anlamlı düzeyde düşüklük saptanmaması nedeniyle daha geniş olgu serileri içeren çalışmalara ihtiyaç olduğuna inanmaktayız.
Interatrial conduction disorders in patients with ST-elevation myocardial infarction
Authors: ALTUNBAŞ Gökhan , VURUŞKAN Ertan , YILMAZ COŞKUN Fatma , SUCU Murat
Published: March 2020

Aim: The most significant clinical association of interatrial block (IAB) was found with increased risk of atrial fibrillation and ischemic stroke. In this study, we sought to evaluate P wave duration and interatrial block in patients presented with acute ST-segment-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).
Materials and Methods: We performed a retrospective analysis of patients presented with acute STEMI who underwent emergent PCI. Follow-up electrocardiograms were obtained from electronic database system. Echocardiographic data were also obtained from electronic patient records. Electrocardiographic measurements were performed using SEMA Workstation 3.8.1 (Schiller AG).
Results: Primary analysis included 200 consecutive patients with STEMI. However, there were 20 in-hospital deaths and 83 patients were lost to follow-up. Remaining 97 patients (80 male, 17 female) were included in the final analysis. Mean age was 57.0212.18 years. There were 48 patients with anterior STEMI and 49 patients with inferior STEMI. Mean duration of follow-up was 11 months and ECGs at the end of the follow up revealed that the frequency of partial and advanced IAB were 13.2% and 7.7% respectively. Statistical analysis showed that neither P wave duration nor IAB showed significant association with the infarct related artery lesion localization. Also, the degree of systolic dysfunction was not associated with IAB. Only male gender and left atrial diameter had significant positive correlation with P wave duration.
Conclusion: IAB was not rare in patients with a history of acute coronary syndrome. The infarct related artery does not seem to have a significant correlation with interatrial conduction.
Diş Hekimliği Fakültesi çalışanlarının hepatit A, hepatit B, hepatit C ve HIV enfeksiyonu yönünden değerlendirilmesi
Authors: MERMUT Gülşen , ERDEM Hüseyin Aytaç , YILDIRIM Çiğdem , YAMAZHAN Tansu , IŞIKGÖZ TAŞBAKAN Meltem , ALTUĞLU İmre , PULLUKÇU Hüsnü
Published: March 2020

Amaç: Kesici delici alet yaralanmaları yanında kan ve diğer potansiyel enfekte vücut sıvılarıyla her türlü mesleki maruziyet sağlık çalışanları için kan yoluyla bulaşan enfeksiyonlar açısından önemli bir risk teşkil etmektedir. Bu çalışmada sağlık çalışanlarının bilgi düzeyleri ve mesleki maruziyet riski nedeniyle Hepatit A, Hepatit B, Hepatit C ve HIV enfeksiyonu yönünden serolojik değerlendirilmesi amaçlandı. Gereç ve Yöntem: Ege Üniversitesi Tıp Fakültesi Hastanesi Enfeksiyon Hastalıkları polikliniğine başvuran 89 sağlık çalışanının 10 soruluk bir anket ile mesleki yaralanma, bilgi düzeyleri ve tutumları ile birlikte Hepatit A, Hepatit B, Hepatit C ve HIV enfeksiyonu yönünden durumları serolojik testle değerlendirildi. Bulgular: Çalışanların 66’sı (%74) kadın, 23’ü (%26) erkek olup, yaş ortalaması 39.94± 12.54 yıl (min-maks;24-66) idi. Mesleki yaralanma tanımlayan 41 kişi (%46) 56 yaralanma öyküsü tanımlandı. Bunların 19’u (%34) iğne batması, 22’si (%39) kesici delici alet yaralanması, 15’i (%27) göze kan/ hasta çıkartısı sıçraması şeklindeydi. Bu yaralanmalar sonucu hepatit B, hepatit C ve HIV bulaşı olmadığı test sonuçları ile görüldü. Sonuç: Kan ya da vücut sıvılarıyla mukozal temas ihtimali olması nedeniyle hepatit B, hepatit C ve HIV bulaşı açısından sağlık çalışanlarının bilgilendirilmesi ve bu yaralanmaları azaltmaya yönelik uygulamalarla farkındalık yaratılmasının önemli olduğunu düşünmekteyiz.
Bulk and Single-Cell Transcriptomics Identify Tobacco-Use Disparity in Lung Gene Expression of ACE2, the Receptor of 2019-nCov
Authors: Cai Guoshuai
Published: March 2020

In current severe global emergency situation of 2019-nCov outbreak, it is imperative to identify vulnerable and susceptible groups for effective protection and care. Recently, studies found that 2019-nCov and SARS-nCov share the same receptor, ACE2. In this study, we analyzed five large-scale bulk transcriptomic datasets of normal lung tissue and two single-cell transcriptomic datasets to investigate the disparities related to race, age, gender and smoking status in ACE2 gene expression and its distribution among cell types. We didn’t find significant disparities in ACE2 gene expression between racial groups (Asian vs Caucasian), age groups (>60 vs <60) or gender groups (male vs female). However, we observed significantly higher ACE2 gene expression in former smoker’s lung compared to non-smoker’s lung. Also, we found higher ACE2 gene expression in Asian current smokers compared to non-smokers but not in Caucasian current smokers, which may indicate an existence of gene-smoking interaction. In addition, we found that ACE2 gene is expressed in specific cell types related to smoking history and location. In bronchial epithelium, ACE2 is actively expressed in goblet cells of current smokers and club cells of non-smokers. In alveoli, ACE2 is actively expressed in remodelled AT2 cells of former smokers. Together, this study indicates that smokers especially former smokers may be more susceptible to 2019-nCov and have infection paths different with non-smokers. Thus, smoking history may provide valuable information in identifying susceptible population and standardizing treatment regimen.
Pulmonary Pathology of Early Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients with Lung Cancer
Authors: Tian Sufang , Hu Weidong , Niu Li , Liu Huan , Xu Haibo , Xiao Shu-Yuan
Published: March 2020

There is currently a lack of pathologic data on the novel coronavirus (SARS-CoV-2) pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.
Deep Arbitrage-Free Learning in a Generalized HJM Framework via Arbitrage-Regularization
Authors: Kratsios Anastasis , Hyndman Cody
Published: March 2020

A regularization approach to model selection, within a generalized HJM framework, is introduced which learns the closest arbitrage-free model to a prespecified factor model. This optimization problem is represented as the limit of a one-parameter family of computationally tractable penalized model selection tasks. General theoretical results are derived and then specialized to affine term-structure models where new types of arbitrage-free machine learning models for the forward-rate curve are estimated numerically and compared to classical short-rate and the dynamic Nelson-Siegel factor models.
Alirocumab Administration Experience to Achieve Low Density Lipoprotein Cholesterol Target Levels in Secondary Prevention of Cardiovascular Disease
Authors: Nikitin A. E. , Averin E. E. , Rozhkov D. E. , Sozykin A. V. , Procenko G. A.
Published: March 2020

Aim. To study the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, alirocumab, on lipid levels in patients who receive secondary prevention of cardiovascular diseases (CVD) and require enhanced lipid-lowering therapy.

Material and methods. The study included 49 patients (aged of 61.53±1.14 years; 31 [63.3%] men) receiving alirocumab who did not reach the target low density lipoprotein cholesterol (LDL-C) concentrations despite the ongoing optimal lipid-lowering therapy. In all patients, the initial level of lipids was evaluated, as well as their parameters after subsequent alirocumab injections.

Results. LDL-C serum level significantly decreased after the first injection compared to the initial level from 2.92±0.22 to 1.65±0.19 mmol/L (p<0.001; Δ45.31±3.61%) and down to 1.74±0.17 mmol/L for the entire study period (p<0.001; Δ41.52±2.69%). The change in LDL-C level between injections did not show statistically significant differences (p=0.141). A direct strong statistically significant correlation between the LDL-C level after the first injection and its average values for the entire observation period was found (r=0.958, p<0.001).

Conclusion. The results of the study indicate that the PCSK9 inhibitor, alirocumab, in patients who need secondary prevention of CVD shows a significant additional decrease in the concentration of LDL-C after the first injection. At the same time, approximately half of the patients were able to achieve the recommended levels of LDL-C. The persistence of the achieved low LDL-C levels over time demonstrated that the average concentration of LDL-C during the observation corresponded to the values after the first injection. This finding shows that there is no need for constant monitoring of lipid metabolism parameters when prescribing such therapy.
The Efficacy, Safety and Adherence to Treatment when New Anticoagulants Taking in Over 75 Years Old Patients with Atrial Fibrillation
Authors: Turov A. N. , Panfilov S. V. , Tschiglinzeva О. V.
Published: March 2020

Aim. To study the efficacy, safety, and adherence to therapy with new oral anticoagulants in patients older than 75 years with atrial fibrillation.

Material and methods. Patients (n=431) over 75 years old (82.7±3.4 years) with various types of atrial fibrillation/flutter (AF) were included in a nonrandomized observational study of new oral anticoagulants (NOAC) in real clinical practice. A history of cardiac surgery was in 27.6% of patients. All patients had >3 risk factors for ischemic stroke (CHA2DS2-VASс 4.81±0.4 points) and >1 risk factor for bleeding (HAS-BLED 3.01±0.2 points). The duration of the observation study was from 12 to 42 (26.9±4.9) months. Dabigatran was taken in 38.5% (n=166) of patients, rivaroxaban – in 41.3% (n=178), apixaban – in 20.2% (n=87) of patients.

Results. The incidence of new cases of myocardial infarction was 0.8% per year, surgical revascularization – 0.9% per year, cardiovascular death – 0.8% per year. The frequency of ischemic stroke was 1.1% per year, transient ischemic attacks – 0.4% per year, all thromboembolic episodes – 1.77% per year. The incidence of intracranial hemorrhage was 0.2% per year, of minor bleeding – 4.4% per year, of the combined cardiac point (the total frequency of all strokes, major bleeding, myocardial infarction, mortality from cardiovascular causes, revascularization procedures) – 4.2% per year. Significant differences in the frequency of endpoints depending on the drug of NOAC taken by patients were not found. Violations of the regimen and doses were more often observed with twice daily intake (63.9% for dabigatran and 59.8% for apixaban) than with a single dosage regimen per day (45.5% for rivaroxaban). The leading causes of non-adherence to NOAC therapy in patients over 75 years of age included skipping the next scheduled dose (43.6%) and changing the frequency of the drug taking (16.9%). For NOAC with a double dose per day, dabigatran and apixaban, the frequency of administration was violated in 27.7% and 28.7%, respectively, and with a single dose per day, rivaroxaban – in 1.1%.

Conclusion. Therapy with NOAC in patients older than 75 years with AF is effective and safe. There were no statistically significant differences in the incidence of thromboembolic or hemorrhagic events during three NOACs treatment in patients with AF older than 75 years. The incidence of non-adherence was less
Guerrilla teaching and a DIY exhibitions: How an assault on comfort zones can engage and inspire
Authors: Compton Martin , Jackson-Bruce Amy , Krastev Viktor
Published: March 2020

This case study and video show the process and outcomes of a ‘flash’ briefing to a group of first-year Fashion Promotion students. The surprise collaborative task was presented to the students outside the comfort of their usual lab space and required them to likewise exhibit previously produced ‘zines’ in a space away from the host institution. With a view to helping students understand how sub-culture artefacts can be exhibited using low-cost, guerrilla marketing strategies, the lecturer drew on some of these same strategies to present the brief. Engagement and participation levels are demonstrably high and the final exhibition is an evident success; the whole experience, we argue, suggests that to challenge norms and to take such risks may well produce positive outcomes. Whilst we believe this case is potentially relevant to anyone interested in higher education pedagogy, the approach is likely to appeal immediately to anyone teaching subjects where promotion is fundamental as well as to those where marketing principles are elemental.
Editors' Introduction
Authors: Warren Liz , Reilly Dawn
Published: March 2020

Introduction to this edition by guest editors from the University of Greenwich Business School.
The mutational spectrum of Hunter syndrome reveals correlation between biochemical and clinical profiles in Tunisian patients
Authors: chkioua latifa , Grissa Oussama , Leban Nadia , Gribaa Moez , Boudabous Hela , Turkia Hadhami Ben , Ferchichi Salima , Tebib Neji , Laradi Sandrine
Published: March 2020

Background:Mucopolysaccharidosis type II (MPS II) or Hunter syndrome is an X-linked recessive lysosomal storage disorder resulting from deficient activity of iduronate 2-sulfatase (IDS) and the progressive lysosomal accumulation of sulfated glycosaminoglycans (GAGs).Methods:A diagnosis of MPS II or Hunter syndrome was performed based on the following approach after a clinical and paraclinical suspicion. Two biochemical and molecular tests were carried out separately and according to the availability of the biological material.Results:All patients in this cohort presented the most common MPS II clinical features. Electrophoresis of GAGs on a cellulose acetate plate in the presence of a high concentration of heparane sulfate showed an abnormal dermatan sulfate band in the patients compared with that in a control case. Furthermore, leukocyte IDS activity ranged from 0.00 to 0.75 nmol/h/mg of leukocyte protein in patients.Five previously reported mutations were identified in this study patients: one splice site mutation, c.240+1G>A; two missense mutations, p.R88P and p.G94D; a large deletion of exon 1 to exon 7; and one nonsense mutation, p.Q396*. In addition, two novel alterations were identified in the MPS II patients: one frame shift mutation, p.D450Nfs*95 and one nonsense mutation, p.Q204*. Additionally, five knownIDSpolymorphisms were identified in the patients: c.419-16 delT, c.641C>T (p.T214M), c.438 C>T (p.T146T), c.709-87G>A, and c.1006+38T>C.Conclusions:The high level of urine GAGs and the deficiency of iduronate 2-sulfatase activity was associated with the phenotype expression of Hunter syndrome. Molecular testing was useful for the patients’ phenotypic classification and the detection of carriers.
Tumor Necrosis Factor-α, Caspase-9 and Heat Shock Protein 70 Expressions with Leukemia Inhibitory Factor in Hydrosalpinx
Authors: Syam Hanom Husni , Djuwantono Tono , Effendi Jusuf S. , Idjradinata Ponpon S. , Madjid Tita H. , Permadi Wiryawan , Septiani Leri
Published: March 2020

Background The leakage of hydrosalpinx fluid from the tube into the uterine cavity is likely to interfere with normal implantation. Hydrosalpinx fluids contain tumor necrosis factor-α (TNF-α), which induces caspase-9 signal transduction, leading to apoptosis. Endometrial cells inhibit apoptosis by synthesizing heat shock protein 70 (Hsp70). The TNF-α, caspase-9 and Hsp70 factors are closely related to apoptosis. In women with hydrosalpinx, the endometrial receptivity of embryonic implantation processes is low. Endometrial receptivity can be assessed by leukemia inhibitory factor (LIF). TNF-α, caspase-9 and Hsp70 expression plays an important role in endometrial receptivity disorders in women with hydrosalpinx.Materials and Methods These is an analytic observational, cross-sectional and categorical comparative study was conducted in 44 subjects with and without hydrosalpinx. The present study was performed in Dr. Hasan Sadikin Hospital, Grha Bunda-, Limijati-Maternity and Children Hospital (May-June 2017). Immunohistochemistry was performed with a cutoff based on the ROC. The Mann-Whitney analysis was performed on TNF-α, caspase-9, Hsp70 and LIF in both groups, whereas a correlation regression test was performed to observe the correlation among these protein.Results The present study used the histoscore as a tool to evaluate the expression of variable between study groups. The comparison of the histoscore for parameters between hydrosalpinx and non-hydrosalpinx subjects was TNF-α (12 vs 9; p<0,001), caspase-9 (12 vs 8,5; p<0,001), Hsp70 (6 vs 8; p<0,001), and LIF (9 vs 12; p<0,05), respectively.Conclusion The results showed a significant difference in TNF-α, caspase-9, Hsp70 and LIF (p <0.05) between hydrosalpinx and non-hydrosalpinx patients. Caspase-9 and Hsp70 are inter-connected and related to LIF as a marker in the endometrium receptivity by hydrosalpinx patients.
Th1/Th17 cytokine profiles are associated with disease severity and exacerbation frequency in COPD patients
Authors: Yu Yan , Zhao Lili , Xie Yu , Xu Yu , Jiao Weike , Wu Jianhui , Deng Xinyu , Fang Guiju , Xue Qing , Zheng Yali , Gao Zhancheng
Published: March 2020

Background T helper (Th) cell cytokine imbalances have been associated with the pathophysiology of chronic obstructive pulmonary disease (COPD), including the Th1/Th2 and Th17/Treg paradigms. Clarifying cytokine profiles during COPD acute exacerbation (AE) and their relationships with clinical manifestations would help in understanding the pathogenesis of disease and improve clinical management.Methods Patients admitted to the hospital with AEs of COPD from January 2017 to August 2017 were included in this study, and follow-up was conducted after discharge (every 30 days, for a total of 120 days). Sputum samples of patients at different time points (including at admission, discharge, and follow-up) were collected, and sputum cytokine profiling (12 cytokines in total) was performed using a Luminex assay. Clinical data of patients were collected by a unified electronic medical record form.Results A total of 87 patients with COPD were enrolled, aged 72 ± 8.5 years, among whom 1, 12, 32, and 42 cases exhibited GOLD stage I, II, III, and IV, respectively. According to the cytokine profiles at admission, patients were divided into three clusters by a k -means clustering algorithm, namely, Th1 high Th17 high (n=26), Th1 low Th17 low (n=56), and Th1 high Th17 low (n=5), which revealed distinct clinical characteristics. Patients with Th1 high Th17 low profile had a significantly longer length of non-invasive ventilation time and length of hospital stay than patients with Th1 high Th17 high profile (7 vs. 0 days, 22 vs. 11 days, respectively, p < 0.05), and had the highest AE frequency. Sputum levels of Th17 cytokines (IL-17A, IL-22, and IL-23) during AE were negatively correlated with AE frequency in the last 12 months ( r = -0.258, -0.289 and -0.216, respectively, p < 0.05). Moreover, decreased sputum IL-17A levels were independently associated with increased AE frequency, whith an OR (95% CI) of 0.975 (0.958 - 0.993) and a p = 0.006.Conclusion Th1/Th17 imbalance during AE is associated with the severity of COPD. Decreased Th17 cytokine expression is correlated with increased AE frequency. The Th1/Th17 balance may be a specific target for the therapeutic manipulation of COPD.Trial registration: ClinicalTrials.gov ID: NCT03236480.
Assessment the Quality of Services in Health Tourism using structural equation modeling (SEM) and confirmatory factor analysis (CFA): a case study in Mashhad, Iran
Authors: Hemmati Farhad , Mahmoudi Ghahraman , Dabbaghi Fatemeh
Published: March 2020

Background: It is essential to improve the quality of services to satisfy health tourists. Thus, the present study was conducted to determine the relationship between quality of health services and tourism in Mashhad.Methods: In this descriptive study, there were 120 subjects from the first population and 384 from the second. They completed a standard questionnaire with items related to demographic characteristics and tourism facilities in the five districts (north, south, east, west, and center) of Mashhad from 2017 to 2018. Data was analyzed using confirmatory factor analysis (CFA) and structural equation modeling (SEM). Spss21 and LISREL8.50 were used as the software. Results: t-test results showed that the factor loadings were more than 1.96, so there was a correlation between the quality of services provided and health tourism in Mashhad. Conclusion: According to the results, the importance of health tourism is so high that efforts for its development it in the region will lead to an all-comprehensive development. Hence, it is suggested that by strengthening the quality of services health tourism be improved in Mashhad.
Pre-clinical studies of honey-related synthetic peptides in malignancy control
Authors: Elawdan Khaled M.E , Elawdan Youssof K. , Eldrieny Ezzat A. , Samy Mohammed B.
Published: March 2020

Backgound: The challenge with malignancy control approaches, although of all traditional methods of treatment like surgery, chemotherapy, radiotherapy, immunotherapy etc. makes more stress upon the scientific community to look for a solution for this challenge even far from the traditional ways. Methods: A growth inhibitory assay was performed. Samples of peptide A and peptide F, 5 mg each, were dissolved in 500 μL Dulbecco’s Phosphate-Buffered Saline to prepare the stock solution, which was added into the wells directly. A 1% trifluoroacetic acid (TFA) solution was used as the control. (a) Cells were placed into a 96-well assay plate at a density of 5000 and 10000 cells/well for adherent and suspension cell lines, respectively, with a 50 μL complete cell culture medium. (b) Stock solutions (10 μL) of the compounds were added into the wells. (c) For data analysis, 10 μL 1% TFA solution was used as control. (d) Complete medium of 40 μL was added into the wells to reach a total volume of 100 μL. (e) The plate was incubated at 37℃ for 72 hours. (f) CellTiter-Glo assay mix solution (50 μL) was added to each well and mixed gently at room temperature for 10 minutes; subsequently, the luminescence was read using PHERAstar Plus (Molecular Devices). Results: Apparent inhibitory effects of those peptides were noticed in 17 of 18 tumour cell lines. Similar effects were noted in an in vivo study using the U87MG tumour mouse model. Conclusion: This study has introduced new synthetic peptides derived from honey proteins, which may help in cancer control through direct apoptotic action not limited to only a certain tumour cell line. Patent: WO/2014/040605A1, US/2015/0291663A1, and CN105283198A.
Evolution of CT Findings in Patients with COVID-19 Pneumonia
Authors: Liang Ting , C.Wu Carol , liu Zhe , Jin Chao , Zhao Huifang , Wang Yan , Wang Zekun , Li Fen , Zhou Jie , Cai Shubo , Liang Yukun , Zhou Heping , Wang Xibin , Ren Zhuanqin , Yang Jian
Published: March 2020

Objectives To delineate the evolution of CT findings in patients with mild COVID-19 pneumonia outside of Wuhan.Methods CT images and medical records of 88 patients with confirmed mild COVID-19 pneumonia outside of Wuhan, a baseline and at least one follow-up CT were retrospectively reviewed. CT features including lobar distribution and presence of ground glass opacities (GGO), consolidation, and linear opacities, were analyzed on per patient basis during each of five time intervals spanning the three weeks after disease onset. Total severity scores were calculated.Results 85.2 % of patients had travel history to Wuhan or known contact with infected individuals. The most common symptoms were fever (84.1%) and cough (56.8%). The baseline CT was obtained on average 5 days from symptom onset. Four patients (4.5%) had negative initial CT. Significant differences were found among the time intervals in the proportion of pulmonary lesions that are 1) pure GGO, 2) mixed attenuation, 3) mixed attenuation with linear opacities, 4) consolidation with linear opacities, and 5) pure consolidation. The majority of patients had involvement of ≥ 3 lobes. Bilateral involvement was more prevalent than unilateral involvement. The proportions of patients observed to have pure GGO or GGO and consolidation decreased over time while proportion of patients with GGO and linear opacities increased. Total severity score showed an increasing trend in the first two weeks. Conclusions While bilateral GGO are predominant features, CT findings changed during different time intervals in the three weeks after symptom onset in patients with COVID-19.
SCIENTIFIC AND METHODICAL APPROACHES TO THE FORMATION AND EVALUATION OF TEAM WORK IN SCIENTIFIC AND EDUCATIONAL PROJECTS
Authors: Lukianykhin V. , Lukianykhina O. , Vovchenko V.
Published: March 2020

The article investigates and generalizes different approaches of scientists to the definition of the concept of "team" "team building", the author's definition is formed. The process of creating a team is explored. The effectiveness of team work is investigated. Guidelines for creating teams have been created.

Keywords:
team, team building, performance evaluation, scientific and educational projects.
ANALYSIS OF EXISTING APPROACHES ABOUT MANAGEMENT AND MINIMIZATION OF CREDIT RISK
Authors: Pokhylko S. , Novikov V.
Published: March 2020

The efficiency of banking performance, related to ensuring reliable protection for banks from credit risk by borrowers, requires resolving multiple issues related to the analysis of their creditworthiness and reliability, as well as development of methods and models to predict the consequences of non-repayment or overdue loans from the borrowers‘ side for the further effective functioning of a bank. Taking into account a considerable amount of scientific works devoted to the research of influence of credit risk on banking there is still a necessity in improvement of existing methods of credit risk management.
The article is devoted to the research of the influence of credit risk on banking in Ukraine, in regard to the analysis of the domestic and foreign approaches and methods of determining banking credit risk; quality of its management and minimization, analysis of the legislation on the definition of exposure to borrower's credit risk; analytical reviews of indicators of the banking system, in particular, research of the banking credit portfolio structure for revealing the reasons of change of particular indicators. And, consequently, their influence on the financial sustainability and bank solvency. The research pays attention to intermediary organizations as participants of contractual relations between banks and borrowers. The authors give their own vision of the efficiency of measures taken by the government to stabilize banking and assess the introduced models of banking credit risk management from a scientific perspective .
The analysis of the indicators showed a growing share of non-performing loans, in particular, the number of overdue assets in the credit portfolio of banks. Which would be caused by the declining production and a decrease in the level of solvency of the population against the background of general political and economic instability in the
country. The study identified the lack of effectiveness of the existing legislation related to credit policy and the work with non-performing loans, which would have contributed to the protection of the banking system from the existing credit risk and corresponded to realities of the modern state of the economy.
Key words: banking, overdue assets, overdue loans, credit, credit risk, credit portfolio.
MACROECONOMIC DETERMINANTS OF ECOLOGICAL TAX EFFECTIVENESS
Authors: Samusevych Ia. , Semenoh A. , Solodukha M.
Published: March 2020

The article is devoted to the study of the factors that influence the efficiency of individual environmental taxes, in particular the tax on air and water pollution, as well as the waste disposal fee, based on the experience of the EU.
The analysis of the European experience of environmental taxation has been carried out and the main groups of environmental taxes in the countries of Europe have been identified; panel regression analysis of factors that influence the volumes and share of tax revenues from environmental taxes is made.
Keywords: ecological taxation, tax revenues, European experience, ecological culture of EU countries
Parameter optimization and mechanism research of enhanced coagulation treatment for Yuquan River water
Authors: Sun Qianshu , Zhao Shuang , Yan Yubo , Jia Wenlin , Yang Weihua
Published: March 2020

As one of the drinking water sources for Xuzhou city, Yuquan River has been polluted seriously in recent years. In this paper, enhanced coagulation technology was selected and various parameters (coagulant species, dosage, solution pH and coagulant aid species) were optimized for Yuquan River water treatment. Turbidity and UV254 removal rate were calculated to assess coagulation efficiencies, and meanwhile floc generation kinetics, zeta potential and scanning electron microscope (SEM) spectra were measured to study the coagulation mechanism. Results indicated that the coagulation effect of polyaluminium chloride (PAC) on Yuquan River water was better than that of aluminium sulphate (AS), and its optimal dosage was 20 mg/L. Flocs produced by PAC also exhibited larger size and faster growth velocity than those of AS. Moreover, the applicable initial pH range for Yuquan River was 6.0–9.0, and the optimal coagulation efficiency was observed at pH 7.0. When PAC or AS was selected as coagulant, the application of sodium alginate (SA) could improve turbidity and UV254 removal due to its adsorption bridging role. In addition, coagulation efficiency could be enhanced in an AS coagulation system when polyacrylamide (PAM) was dosed as coagulant aid.
Application of Moringa oleifera Lam. fractionated proteins for inactivation of Escherichia coli from water
Authors: Silveira Fabiane Masala R. , Baptista Aline Takaoka A. , Dutra Tatiane V. , de Abreu Filho Benício Alves , Gomes Raquel G. , Bergamasco Rosângela
Published: March 2020

Chemical products traditionally used in the disinfection of water bodies often pose human health risks. For this reason, studies on natural coagulants such as Moringa oleifera Lam. represent an alternative for the inactivation of pathogenic microorganisms, among which is Escherichia coli. This study evaluated the effect of different concentrations of coagulants obtained from Moringa seed extracts and their protein fractions in the inactivation of E. coli during the coagulation/flocculation process. The coagulants studied were the aqueous extract, saline extract and protein fractions albumin and globulin, highlighting that the protein fractions were more effective on inactivating E. coli. The protein fraction globulin at a concentration of 10.0 mg L−1 showed bactericidal effects against E. coli within 18 min, whereas the albumin showed a bacteriostatic effect within 48 min because it isolated colonies in the sediment sample.
Study on demulsification and deoiling for O/W emulsion by microbubble pretreated resin
Authors: Wang Xiaoping , Liu Wei , Liu Xueqian , Luo Jihang
Published: March 2020

The microbubble pretreated resin was used for demulsification and deoiling of the simulated O/W emulsion. The demulsification and deoiling performance and the influencing factors were investigated systematically. Experimental results indicate that the microbubble pretreated resin reaches a 97% oil removal within 80 min; on the contrary, oil removals are 90% and 85% for NaOH solution soaked and un-pretreated resins respectively. After five repeated runs, the oil removal of microbubble pretreated resin can be maintained at over 70%. The demulsification mechanism was revealed by comparing zeta potential, surface tension, contact angle of the emulsion in treatment, and the characterization results of the resin before and after use. Three possible pathways of demulsification were concluded and the ranking contributions can be shown below. Pathway 1: Competitive trapping of surfactant. The cationic groups of the resin combine with the anionic groups of the surfactant and drag them away from the oil particle surface. Pathway 2: Distribution equilibrium of surfactant. Free surfactants in the emulsion are captured by resin and reduce the concentration of uncombined surfactant. This results in surfactants on the oil particle partly detaching from the oil surface to maintain the adsorption-desorption equilibrium of the surfactant. Pathway 3: Adsorption coalescence.
Preparation of sludge-based hydrochar at different temperatures and adsorption of BPA
Authors: Chen Liyuan , Li Dapeng , Huang Yong , Zhu Wenjuan , Ding Yuqin , Guo Chaoran
Published: March 2020

This study sought a new way to utilize sludge as a low cost and efficient adsorbent. Preparation of sludge adsorbent by hydrothermal carbonization was done at different temperatures (160–250 °C). Various characterization techniques were used in this study including elemental analysis, Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). The adsorption performance of the organic matter was analyzed by adsorption experiments with the endocrine disruptor bisphenol A (BPA). Results showed that as the hydrothermal temperature increased, the solid yield of hydrochar decreased from 84.73% to 55.19%, and the maximum specific surface area was 11.9 m2/g. Elemental analysis showed that the hydrochar contains more aromatic carbon than the raw sludge. It was found using the FT-IR and XPS that the hydrochar retains a large amount of oxygen-containing functional groups on the surface after hydrothermal treatment. Hydrochar can be used as an organic-pollutant adsorbent in water; it has a good adsorption effect on BPA and the removal rate can reach 96%. The adsorbed hydrochar can be hydrothermally retreated and returned to the sewage treatment plant for reuse.