bluuebunny/crossref_metadata_2025 huggingface dataset:
Altered functional connectivity of the primary motor cortex in tremor dominant and postural instability gait difficulty subtypes of early drug-naive Parkinson’s disease patients
Authors: Wang Qi , Yu Miao , Yan Lei , Xu Jianxia , Wang Yajie , Zhou Gaiyan , Liu Weiguo
Published: May 2023

Background

The primary motor cortex (M1) is an important hub in the motor circuitry of Parkinson’s disease (PD), but the subregions’ function and their correlation to tremor dominant (TD) and postural instability and gait disturbance (PIGD) with PD remain unclear. This study aimed to determine whether the functional connectivity (FC) of the M1 subregions varied between the PD and PIGD subtypes.

Methods

We recruited 28 TD patients, 49 PIGD patients, and 42 healthy controls (HCs). M1 was divided into 12 regions of interest using the Human Brainnetome Atlas template to compare FC among these groups.

Results

Compared with HCs, TD and PIGD patients exhibited increased FC between the left upper limb region (A4UL_L) and the right caudate nucleus (CAU)/left putamen (PUT), between the right A4UL (A4UL_R) and the left anterior cingulate and paracingulate gyri (ACG)/bilateral cerebellum4_5 (CRBL4_5)/left PUT/right CAU/left supramarginal gyrus/left middle frontal gyrus (MFG), as well as decreased connectivity between the A4UL_L and the left postcentral gyrus and the bilateral cuneus, and between the A4UL_R and the right inferior occipital gyrus. TD patients showed increased FC between the right caudal dorsolateral area 6 (A6CDL_R) and the left ACG/right MFG, between the A4UL_L and the right CRBL6/right middle frontal gyrus, orbital part/bilateral inferior frontal gyrus, and orbital part (ORBinf), and between the A4UL_R and the left ORBinf/right MFG/right insula (INS). PIGD patients displayed increased connectivity between the A4UL_L and the left CRBL4_5. Compared with PIGD patients, TD patients exhibited increased connectivity between the A6CDL_R and the left ACG/right MFG and between the A4UL_R and the left ACG/left ORBinf/right INS/right MFG. Furthermore, in TD and PIGD groups, the FC strength between the A6CDL_R and right MFG was negatively correlated with PIGD scores, while the FC strength between the A4UL_R and left ORBinf/right INS was positively correlated with TD scores and tremor scores.

Conclusion

Our results demonstrated that early TD and PIGD patients share some common injury and compensatory mechanisms. TD patients occupied more resources in the MFG, ORBinf, INS, and ACG, which can be used as biomarkers to distinguish them from PIGD patients.
Lasting impairments following transient ischemic attack and minor stroke: a systematic review protocol
Authors: Hede Ebbesen Birgitte , Modrau Boris , Kontou Eirini , Finch Emma , Crowfoot Gary , Crow Jennifer , Heron Neil , Hodson Tenelle , Skrubbeltrang Conni , Turner Grace
Published: May 2023

Introduction

The focus on medical management and secondary prevention following Transient Ischemic Attack (TIA) and minor stroke is well-established. Evidence is emerging that people with TIA and minor stroke can experience lasting impairments as fatigue, depression, anxiety, cognitive impairment, and communication difficulties. These impairments are often underrecognized and inconsistently treated. Research in this area is developing rapidly and an updated systematic review is required to evaluate new evidence as it emerges. This living systematic review aims to describe the prevalence of lasting impairments and how they affect the lives of people with TIA and minor stroke. Furthermore, we will explore whether there are differences in impairments experienced by people with TIA compared to minor stroke.

Methods

Systematic searches of PubMed, EMBASE, CINAHL, PsycINFO, Cochrane Libraries will be undertaken. The protocol will follow the Cochrane living systematic review guideline with an update annually. A team of interdisciplinary reviewers will independently screen search results, identify relevant studies based on the defined criteria, conduct quality assessments, and extract data. This systematic review will include quantitative studies on people with TIA and/or minor stroke that report on outcomes in relation to fatigue, cognitive and communication impairments, depression, anxiety, quality of life, return to work/education, or social participation. Where possible, findings will be grouped for TIA and minor stroke and collated according to the time that follow-up occurred (short-term < 3 months, medium-term 3–12 months, and long-term > 12 months). Sub-group analysis on TIA and minor stroke will be performed based on results from the included studies. Data from individual studies will be pooled to perform meta-analysis where possible. Reporting will follow the Preferred Reporting Items for Systematic review and Meta-Analysis Protocol (PRISMA-P) guideline.

Perspectives

This living systematic review will collate the latest knowledge on lasting impairments and how these affect the lives of people with TIA and minor stroke. It will seek to guide and support future research on impairments emphasizing distinctions between TIA and minor stroke. Finally, this evidence will allow healthcare professionals to improve follow-up care for people with TIA and minor stroke by supporting them to identify and address lasting impairments.
Postoperative cerebral hemorrhage death in a patient with secondary hyperparathyroidism: a report of one case and literature review
Authors: Zhou Peng , Xu Jing , Zhuang Dayong , Li Xiaolei , Yue Tao , Hu Huaiqiang , He Qingqing
Published: May 2023

Secondary Hyperparathyroidism (SHPT) is a common complication of end-stage renal disease (ESRD), and parathyroid surgery (PTX) is an effective way to treat patients with severe SHPT. ESRD has multiple associations with cerebrovascular diseases. For example, the incidence of stroke in patients with ESRD is 10 times higher than that in the general population, the risk of death after acute stroke is three times higher, and the risk of hemorrhagic stroke is significantly higher. High/low serum calcium, high PTH, low serum sodium, high white blood cell count, previous occurrences of cerebrovascular events, polycystic kidney disease (as a primary disease), and the use of anticoagulants are independent risk factors for hemorrhagic stroke in hemodialysis patients with uremia. The risk of stroke in patients who undergo PTX decreases significantly in the second year of follow-up and persist thereafter. However, studies on the risk of perioperative stroke in SHPT patients are limited. After undergoing PTX, the PTH levels in SHPT patients drop suddenly, they undergo physiological changes, bone mineralization increases, and calcium in the blood gets redistributed, often accompanied by severe hypocalcemia. Serum calcium might influence the occurrence and development of hemorrhagic stroke at various stages. To prevent bleeding from the operated area, the use of anticoagulants after surgery is reduced in some cases, which often decreases the frequency of dialysis and increases the quantity of fluid in the body. An increase in the variation in blood pressure, instability of cerebral perfusion, and extensive intracranial calcification during dialysis promote hemorrhagic stroke, but these clinical problems have not received enough attention. In this study, we reported the death of an SHPT patient who suffered a perioperative intracerebral hemorrhage. Based on this case, we discussed the high-risk factors for perioperative hemorrhagic stroke in patients who undergo PTX. Our findings might help in the identification and early prevention of the risk of profuse bleeding in patients and provide reference for the safe performance of such operations.
Analysis of circadian rhythm components in EEG/EMG data of aged mice
Authors: Masuda Kosaku , Katsuda Yoko , Niwa Yasutaka , Sakurai Takeshi , Hirano Arisa
Published: May 2023

Aging disrupts circadian clocks, as evidenced by a reduction in the amplitude of circadian rhythms. Because the circadian clock strongly influences sleep–wake behavior in mammals, age-related alterations in sleep–wake patterns may be attributable, at least partly, to functional changes in the circadian clock. However, the effect of aging on the circadian characteristics of sleep architecture has not been well assessed, as circadian behaviors are usually evaluated through long-term behavioral recording with wheel-running or infrared sensors. In this study, we examined age-related changes in circadian sleep–wake behavior using circadian components extracted from electroencephalography (EEG) and electromyography (EMG) data. EEG and EMG were recorded from 12 to 17-week-old and 78 to 83-week-old mice for 3 days under light/dark and constant dark conditions. We analyzed time-dependent changes in the duration of sleep. Rapid eye movement (REM) and non-REM (NREM) sleep significantly increased during the night phase in old mice, whereas no significant change was observed during the light phase. The circadian components were then extracted from the EEG data for each sleep–wake stage, revealing that the circadian rhythm in the power of delta waves during NREM sleep was attenuated and delayed in old mice. Furthermore, we used machine learning to evaluate the phase of the circadian rhythm, with EEG data serving as the input and the phase of the sleep–wake rhythm (environmental time) as the output. The results indicated that the output time for the old mice data tended to be delayed, specifically at night. These results indicate that the aging process significantly impacts the circadian rhythm in the EEG power spectrum despite the circadian rhythm in the amounts of sleep and wake attenuated but still remaining in old mice. Moreover, EEG/EMG analysis is useful not only for evaluating sleep–wake stages but also for circadian rhythms in the brain.
Adaptations in the transformation of cassava (Manihot esculenta Crantz; Euphorbiaceae) for consumption in the dietary management of diabetes: the case of Palikur, or Parikwene People, from French Guiana
Authors: Rapinski Michael , Cuerrier Alain , Davy Damien
Published: May 2023

Introduction

In the French overseas department of French Guiana, in South America, nutrition therapy for the management of diabetes is based on French guidelines. However, this region is demographically diverse and includes several populations of Indigenous Peoples, Parikwene among others, also called Palikur. Due to socio-economical, cultural, and geographical differences, along with distinctions in the local food system, dietary recommendations, which many consider in the context of post-colonial power dynamics, are not well suited to local populations. In the absence of suitable recommendations, it is hypothesized that local populations will adapt their dietary practices considering diabetes as an emerging health problem.

Methods

Seventy-five interviews were conducted with community members and Elders, as well as healthcare professionals and administrators providing services to the Parikwene population of Macouria and Saint-Georges de l’Oyapock communes. Data regarding the representation of cassava (Manihot esculenta Crantz) consumption and diabetes were collected via semi-structured interviews and participant observation (i.e., observation and participation in community activities), namely via participating in activities related to the transformation of cassava tubers at swidden and fallow fields.

Results and Discussion

Parikwene have adapted the transformation of cassava tubers for their consumption in the management of diabetes.The importance of cassava tubers as a staple and core food to the Parikwene food system was established by identifying it as a cultural keystone species. Narratives illustrated conflicting perceptions regarding the implication of cassava consumption in the development of diabetes. Adaptations to the operational sequence involved in the transformation of cassava tubers led to the production of distinct cassava roasted semolina (i.e., couac), based on organoleptic properties (i.e., sweet, and acidic couac). Preferences for the consumption of acidic couac were grounded in the Parikwene knowledge system, as well as attention to diabetes related symptoms and glucometer readings.

Conclusion

These results provide important insights related to knowledge, attitudes, and practices in developing locally and culturally adapted approaches to providing dietary recommendations in the treatment of diabetes.
Efficacy and feasibility of Apatinib and S-1 as a novel oral induction therapy in locally advanced head and neck squamous cell carcinoma: an exploratory phase 2 open-label, single-arm trial
Authors: Jiang Wen , Li Rongrong , Zhang Lin , Dou Shengjin , Ye Lulu , Shao Ziyang , Wu Sicheng , Dong Minjun , Li Jiang , Zhu Guopei
Published: May 2023

Objectives

The current standard nonsurgical treatment for locally advanced head and neck squamous cell cancer (LA-HNSCC) is concomitant chemoradiotherapy (CRT). Neoadjuvant chemotherapy combined with CRT has been explored in HNSCC patients and is an acceptable strategy. However, the occurrence of adverse events (AEs) restricts its application. We conducted a clinical study to explore the efficacy and feasibility of a novel induction therapy with orally administered apatinib and S-1 in LA-HNSCC.

Materials and methods

This nonrandomized, single-arm, prospective clinical trial included patients with LA-HNSCCs. The eligibility criteria included histologically or cytologically confirmed HNSCC, with at least one radiographically measurable lesion detected by magnetic resonance imaging (MRI) or computerized tomography (CT) scan, age 18–75 years, and a diagnosis of stage III to IVb according to the 7th edition of the American Joint Committee of Cancer (AJCC). Patients received induction therapy with apatinib and S-1 for three cycles (3 weeks/cycle). The primary endpoint of this study was the objective response rate (ORR) to induction therapy. The secondary endpoints included progression-free survival (PFS), overall survival (OS), and AEs during induction treatment.

Results

From October 2017 to September 2020, 49 patients with LA-HNSCC were screened consecutively and 38 were enrolled. The median age of the patients was 60 years (range, 39-75). Thirty-three patients (86.8%) had stage IV disease according to the AJCC staging system. The ORR after induction therapy was 97.4% (95% confidence interval [CI]: 86.2%-99.9%). the 3-year OS rate was 64.2% (95% CI: 46.0%-78.2%) and 3-year PFS was 57.1% (95% CI: 40.8%-73.6%). The most common AEs during induction therapy were hypertension and hand-foot syndrome, which were manageable.

Conclusion

Apatinib combined with S-1 as novel induction therapy for LA-HNSCC patients resulted in a higher-than-anticipated ORR and manageable adverse effects. With the associated safety profile and preferable oral administration route, apatinib combined with S-1 is an attractive exploratory induction regimen in outpatient settings. However, this regimen failed to show a survival benefit.

Clinical trial registration

https://clinicaltrials.gov/show/NCT03267121, identifier NCT03267121.
Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism
Authors: Luo Maocai , Zheng Yuhong , Tang Shiyun , Gu Linsen , Zhu Yi , Ying Rongtao , Liu Yufei , Ma Jianli , Guo Ruixin , Gao Peiyang , Zhang Chuantao
Published: May 2023

Background: The incidence of glycolipid metabolic diseases is extremely high worldwide, which greatly hinders people’s life expectancy and patients’ quality of life. Oxidative stress (OS) aggravates the development of diseases in glycolipid metabolism. Radical oxygen species (ROS) is a key factor in the signal transduction of OS, which can regulate cell apoptosis and contribute to inflammation. Currently, chemotherapies are the main method to treat disorders of glycolipid metabolism, but this can lead to drug resistance and damage to normal organs. Botanical drugs are an important source of new drugs. They are widely found in nature with availability, high practicality, and low cost. There is increasing evidence that herbal medicine has definite therapeutic effects on glycolipid metabolic diseases.

Objective: This study aims to provide a valuable method for the treatment of glycolipid metabolic diseases with botanical drugs from the perspective of ROS regulation by botanical drugs and to further promote the development of effective drugs for the clinical treatment of glycolipid metabolic diseases.

Methods: Using herb*, plant medicine, Chinese herbal medicine, phytochemicals, natural medicine, phytomedicine, plant extract, botanical drug, ROS, oxygen free radicals, oxygen radical, oxidizing agent, glucose and lipid metabolism, saccharometabolism, glycometabolism, lipid metabolism, blood glucose, lipoprotein, triglyceride, fatty liver, atherosclerosis, obesity, diabetes, dysglycemia, NAFLD, and DM as keywords or subject terms, relevant literature was retrieved from Web of Science and PubMed databases from 2013 to 2022 and was summarized.

Results: Botanical drugs can regulate ROS by regulating mitochondrial function, endoplasmic reticulum, phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT), erythroid 2-related factor 2 (Nrf-2), nuclear factor κB (NF-κB), and other signaling pathways to improve OS and treat glucolipid metabolic diseases.

Conclusion: The regulation of ROS by botanical drugs is multi-mechanism and multifaceted. Both cell studies and animal experiments have demonstrated the effectiveness of botanical drugs in the treatment of glycolipid metabolic diseases by regulating ROS. However, studies on safety need to be further improved, and more studies are needed to support the clinical application of botanical drugs.
Therapeutic effect of fenofibrate for non-alcoholic steatohepatitis in mouse models is dependent on regime design
Authors: Wang Xinxue , Luo Jia , Lu Zhuoheng , Fang Shenzhe , Sun Mengxia , Luo Wenjing , Shen Jianwei , Liu Aiming , Ye Hua
Published: May 2023

Background: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver diseases. In most cases, NAFLD progresses from benign steatosis to steatohepatitis (NASH), and then to cirrhosis. No treatment is currently approved for NAFLD/NASH in the clinic. Fenofibrate (FENO) has been clinically used to treat dyslipidemia for more than a half century, but its effects on NASH are not established. FENO’s half-life is quite different between rodent and human. The aim of this study was to investigate the potential of pharmacokinetic-based FENO regime for NASH treatment and the underlying mechanisms.

Methods: Two typical mouse NASH models, methionine-choline deficient (MCD) diet-fed mice and choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD)-fed mice, were used. MCD model was designed as therapeutic evaluation in experiment 1 and CDAHFD model was designed as preventive in experiment 2. Three doses of FENO (5, 25, 125 mg/kg), two times a day (BID), were administered to the above models. Serum markers of liver injury, cholestasis, and the histology of liver tissues were investigated. Normal mice were used as a model in experiment 3 for toxicity evaluation, Quantitative-PCR and Western Blot assays were used to investigate the inflammatory responses, bile acid synthesis as well as lipid catabolism.

Results: Mice on the MCD and CDAHFD diets developed steatohepatitis as expected. Treatment with FENO (25 mg/kg·BID) significantly decreased hepatic steatosis, inflammation and fibrosis in both therapeutic and preventive models. In the MCD model, the therapeutic action of FENO (25 mg/kg·BID) and 125 mg/kg·BID on histopathology and the expression of inflammatory cytokines were comparable. In reducing macrophage infiltration and bile acid load, FENO (25 mg/kg·BID) was superior to 125 mg/kg·BID. In all the aspects mentioned above, FENO (25 mg/kg·BID) was the best among the 3 doses in the CDAHFD model. In a third experiment, the effects of FENO (25 mg/kg·BID) and 125 mg/kg·BID on lipid catabolism were comparable, but 125 mg/kg·BID increased the expression of inflammatory factors and bile acid load. In both models, FENO (5 mg/kg·BID) showed little effect in hepatic steatosis and inflammation, neither the adverse effects. FENO (125 mg/kg·BID) aggravated liver inflammation, increased bile acid synthesis, and promoted the potential of liver proliferation. In toxicity risk assay, FENO (25 mg/kg·BID) treatment showed low potential to trigger bile acid synthesis, inflammation and hepatocyte proliferation.

Conclusion: A new regime, FENO (25 mg/kg·BID) is potentially a therapeutic strategy for the NASH treatment. Translational medicine is warranted to prove its effectiveness in the clinic.
Experimental studies on the performance evaluation of water-soluble polymers used as temporary plugging agents
Authors: Wu Guangai , Chen Zhengrong , Zhang Anshun , Zhou Jun , Hou Yanan , Xie Xin , Wu Jianshu , Kong Xiangwei , Li Song
Published: May 2023

The performance of the temporary plug is a key factor in determining the success of loss-circulation control and temporary plug diversion fracturing. Due to the complexity of geomechanics and working conditions, current commonly used temporary plug agents face problems such as low plug strength and efficiency, large filtration losses due to failure to form filter cakes, and slow degradation affecting the recovery of fracture conductivity. A novel idea for the development of a novel water-soluble polymer plug for fracking is proposed, namely, low-to middle-molecule weight + reinforced chain rigidity + supramolecular aggregation. Using sodium bisulfite and potassium sulfate as initiators, AA, AM, and AMPS as grafting monomers, and SM as hydrophobic functional monomers, the AM-AA-AMPS-SM copolymer was prepared by polymerization. The developed new temporary plugging agent was completely degraded at 70°C for 5–8 h by carrying out experimental evaluation tests, such as water absorption expansion rate, swelling kinetics, density, post-dissolution viscosity, strength of the temporary plugging agent and post-degradation conductivity. After degradation, the viscosity of the solution is 2.5–3.6 mPa s with good fluidity and no gel remnants. The density of the temporary plug material is about 1.14 g/cm3. The absorption expansion rate was 25.8 g/g. The pressure is 60.1 MPa when the thickness of the granular temporary plug is 0.4 cm. Under experimental conditions, the fracture conductivity was found to be 69–123 D*cm at a closing pressure of 30 MPa after degradation of the temporary plug. The test results demonstrate that the new temporary plug agent, with its high plug strength, temperature-controlled degradation, reflux stability and effective self-support after degradation, can meet the requirements of drilling plug and temporary plug fracturing technologies.
Heavy-flavor hadron decays producing muon cross sections in pp collisions at high transverse momentum
Authors: Zhang Zuman , Li Sha , Yu Ning , Zhu Zhong
Published: May 2023

The focus of this work was on investigating and comparing two methods for calculating the cross sections of muons produced by the decay of heavy-flavor hadrons in pp collisions, which cover the interval 2<pT< 20 GeV/c at a center-of-mass energy of s = 7 TeV. One method involves using the fixed-order plus next-to-leading logarithms (FONLL) approach to scale the measured pT-differential cross section of muons from heavy-flavor hadron decay in pp collisions at a center-of-mass energy of s = 5.02 TeV. The other method involves using FONLL calculations to extrapolate the published measured pT-differential cross section at s = 7 TeV to higher pT. In these two methods, we can use the published measured pT-differential cross section at s = 5.02 TeV and s = 7 TeV, which cover the interval 2<pT< 20 GeV/c and 2<pT< 12 GeV/c, respectively. In terms of consistency within uncertainties, the results from both methods were compared not only to pQCD-based FONLL calculations but also to each other. Because they provide the necessary pp reference, these calculations are critical for determining the nuclear modification factor of muons from heavy flavor decays in heavy-ion collisions.
The impact of sport-specific physical fitness change patterns on lower limb non-contact injury risk in youth female basketball players: a pilot study based on field testing and machine learning
Authors: Huang Yuanqi , Li Changfei , Bai Zhanshuang , Wang Yukun , Ye Xiaohong , Gui Yuheng , Lu Qiang
Published: May 2023

Background: In recent years, identifying players with injury risk through physical fitness assessment has become a hot topic in sports science research. Although practitioners have conducted many studies on the relationship between physical fitness and the likelihood of injury, the relationship between the two remains indeterminate. Consequently, this study utilized machine learning to preliminary investigate the relationship between individual physical fitness tests and injury risk, aiming to identify whether patterns of physical fitness change have an impact on injury risk.

Methods: This study conducted a retrospective analysis by extracting the records of 17 young female basketball players from the sport-specific physical fitness monitoring and injury registration database in Fujian Province. Sports-specific physical fitness tests included physical performance, physiological, biochemical, and subjective perceived responses. The data for each player was standardized individually using Z-scores. Synthetic minority over-sampling techniques and edited nearest neighbor algorithms were used to sample the training set to address the negative impact of class imbalance on model performance. Feature extraction was performed on the dataset using linear discriminant analysis, and the prediction model was constructed using the cost-sensitive neural network.

Results: The 10 replicate 5-fold stratified cross-validation showed that the lower limb non-contact injury prediction model based on the cost-sensitive neural network had achieved good discrimination and calibration (average Precision: 0.6360; average Recall: 0.8700; average F2-Score: 0.7980; average AUC: 0.8590; average Brier-score: 0.1020), which could be well applied in training practice. According to the attribution analysis, agility and speed were important physical attributes that affect youth female basketball players’ non-contact lower limb injury risk. Specifically, there was enhance in the performance of the 1-min double under, accompanied by an increase in urinary ketone and urinary blood levels following the agility test. The 3/4 basketball court sprint performance improved, while urinary protein and RPE levels decreased after the speed test.

Conclusion: The sport-specific physical fitness change pattern can impact the lower limb non-contact injury risk of young female basketball players in Fujian Province, specifically in terms of agility and speed. These findings will provide valuable insights for planning athletes’ physical training programs, managing fatigue, and preventing injuries.
Genetic and morphological characterization of United States tea (Camellia sinensis): insights into crop history, breeding strategies, and regional adaptability
Authors: Clarke Caitlin , Richter Brantlee Spakes , Rathinasabapathi Bala
Published: May 2023

Multiple introductions of tea (Camellia sinensis) to the United States since the 1850s have resulted in US tea germplasm that are currently poorly characterized. To resolve questions concerning the relatedness and regional adaptability of US tea germplasm, 32 domestic individuals were evaluated using 10 InDel markers, and compared with a background population of 30 named and registered Chinese varieties of tea. The marker data were analyzedviaa neighbor-joining cladistic tree derived from Nei’s genetic distance, STRUCTURE, and Discriminant Analysis of Principal Components, which revealed four genetic groups. Nineteen individuals selected from the four groups were assessed for seven leaf traits, two floral descriptors, and leaf yield, to identify plants best adapted to Florida field conditions. Our analyses compared with available historical records led us to estimate the most likely provenance of some of the US individuals, to precisely identify tea plant material and to choose most diverse accessions for breeding tea improved for adaptability, yield and quality.
Traces of health—A landscape design task as a diagnostic aid for detecting mental burden? A qualitative focus group study
Authors: Niedermann Christina , Anheyer Dennis , Seeligmüller Emily , Ostermann Thomas
Published: May 2023

Background

Mental disorders are most common causes of illness worldwide. Studies on art and drawing tasks, such as the tree-drawing test have already proven their prognostic quality for the diagnosis of Alzheimer’s disease, depression or trauma. In the depiction of art in public space, gardens and landscapes are one of the oldest human forms of artistic expression. This study thus aims at exploring the impact of a landscape design task as a prognostic tool to detect mental burden.

Materials and methods

A total of 15 individuals (eight female) aged between 19 and 60 years completed the Brief Symptom Inventory BSI-18 and the State Trait Anxiety Inventory (STAI-S) before being asked to design a landscape in a 3 × 3 m squared area. Material to be used included plants, flowers, branches, and stones. The complete process of landscape design was videotaped and the tapes were analyzed in a two-step focus group analysis from a group of gardening trainees, psychology students and students of arts therapies. Results were condensed in a second step into major categories.

Results

Scores of the BSI-18 showed a range of 2–21 points and STAI-S scores ranged between 29 and 54 points indicating a light to moderate mental burden. Focus group participants identified three mutually perpendicular major components associated with mental health: “Movement and Activity,” “Material Selection and Design,” and “Connectedness to the task.” In a subsample of the three least and three most mentally stressed subjects (based on their GSI and STAI-S scorings), clear differences were found in body posture, action planning and the choice of material and aspects of design.

Discussion

In addition to the well-known therapeutic potential of gardening, this study for the first time showed that gardening and landscape design contains diagnostic elements. Our preliminary findings are in coherence with similar research indicating a high association of movement and design patterns with mental burden. However, due to the pilot nature of the study, the results should be interpreted cautiously. Based on the findings further studies are currently planned.
The effect of structured stepwise presentations on students’ fraction learning: an eye-tracking study
Authors: Shang Xiaoqing , Li Rangmei , Li Yangping
Published: May 2023

The structured stepwise presentation is based on the segmenting and cueing principles. The main purpose of the study was to examine the effect of the structured stepwise presentations on students’ attention and fraction learning. A total of 100 primary pupils participated in this study. They were divided into three parallel groups and were, respectively, applied three kinds of presentation types (structured and stepwise, no structure and stepwise, and structure and no stepwise) of the teaching content to learn the fraction concept. A stable eye tracker was used to record students’ visual attention during learning, the first fixation duration and total fixation duration of students were recorded, and the regression time was also calculated within correspondent relative elements. After the experiment, through a one-way ANOVA test, we found significant differences among the three groups in students’ attention. The learning performance of these three groups also differed. The results showed that structured stepwise presentation played an important role in attention guidance during fraction teaching. It better guided students’ attention to connecting relative elements and resulted in better learning performance in fraction learning. The findings suggested the importance of structured stepwise presentations during teaching practices.
In their own words: deception detection by victims and near victims of fraud
Authors: Junger Marianne , Koning Luka , Hartel Pieter , Veldkamp Bernard
Published: May 2023

Aim

Research on deception detection has usually been executed in experimental settings in the laboratory. In contrast, the present research investigates deception detection by actual victims and near victims of fraud, as reported in their own words.

Materials and methods

Our study is based on a nationally representative survey of 11 types of (mostly) online fraud victimization (N = 2,864). We used qualitative information from actual victims and near victims on why they didn’t fall for the fraud, or how, in hindsight, it could have been prevented.

Results

The main detection strategies mentioned by near victims (N = 958) were 1) fraud knowledge (69%): these near victims clearly recognized fraud. Other strategies related to fraud knowledge were: noticing mistakes (27.9%), rules and principles about safe conduct (11.7%), and personal knowledge (7.1%). A second type of strategy was distrust (26.1%). A third strategy was ‘wise through experience’ (1.6%). Finally, a limited number of respondents (7.8%) searched for additional information: they contacted other people (5.5%), sought information online (4%), contacted the fraudster (2.9%), contacted their bank or credit card company (2.2%), or contacted the police (0.2%). Using knowledge as a strategy decreases the probability of victimization by a factor of 0.43. In contrast, all other strategies increased the likelihood of victimization by a factor of 1.6 or more. Strategies generally were uncorrelated, several strategies differed by type of fraud. About 40% of the actual victims (N = 243) believed that their victimization might have been prevented by: 1) seeking information (25.2%), 2) paying more attention (18.9%), 3) a third party doing something (16.2%), 4) following safety rules or principles, like using a safer way of paying or trading (14.4%), or by 5) ‘simply not going along with it’ (10.8%). Most of these strategies were associated with a higher, not lower, likelihood of victimization.

Conclusion

Clearly, knowledge of fraud is the best strategy to avoid fraud victimization. Therefore, a more proactive approach is needed to inform the public about fraud and attackers’ modus operandi, so that potential victims already have knowledge of fraud upon encountering it. Just providing information online will not suffice to protect online users.
Development of the reading literacy questionnaire for EFL learners at primary schools
Authors: Li Weilai , Kang Shumin , Shao Yanhong
Published: May 2023

Previous studies have indicated that there are a variety of factors influencing reading literacy assessment, including linguistic, cognitive, and affective factors, but little has been done on how to integrate these influential factors reasonably in a reading literacy instrument. As such, the purpose of this study is to develop and validate an English Reading Literacy Questionnaire (ERLQ) for English as foreign language (EFL) learners at the elementary level. The ERLQ was designed and revised through three rounds of validation with a sample of 784 pupils (Grades 3–6) in six primary schools from six provinces in China. Validity and reliability tests of the questionnaire were conducted with item analysis, Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), reliability test, and the analysis of criterion validity in SPSS 26.0 and AMOS 23.0. Results indicated that the revised ERLQ had high internal consistency, ranging from 0.729 to 0.823. The criterion validity of the ERLQ was supported by significant correlations to the Chinese Students’ English Rating Scale verified by the authoritative department, with a correlation coefficient of 0.871. The study shows that the revised questionnaire, with 3 dimensions of 14 items, has high reliability and validity, which can be used as an assessment instrument for the intended audience. It also suggests that modifications may be made for further use in other regions and countries, depending on the background information of the learners.
Physiological feedback technology for real-time emotion regulation: a systematic review
Authors: Sun Yifan , Lu Tian , Wang Xuanyi , Chen Wanlin , Chen Shulin , Chen Hang , Zheng Jing
Published: May 2023

Background

Previous studies suggest that physiological feedback can be an effective method for emotion regulation (ER). However, studies on the specific effects of physiological feedback have shown conflicting results due to inconsistencies in study designs. Therefore, we present this systematic review to further validate the effectiveness of physiological feedback for ER, clarify its specific effects, as well as summarize the factors that influence its effectiveness.

Method

This systematic review following PRISMA guidelines covers all studies using physiological feedback in emotions. A literature search was conducted in Web of Science, PubMed, PsychINFO, China National Knowledge Infrastructure, and WANFANG DATA. And a standardized quality assessment was performed.

Results

We identified 27 relevant articles (25 studies), and the majority of these studies showed a significant regulatory effect of physiological feedback on different emotions. The feedback's content, explanation, authenticity, real-time capability, and modality were the key factors that influenced its effects, and this technology will achieve its optimal ER effect when these factors are considered comprehensively.

Conclusions

These findings further confirmed the effectiveness of physiological feedback as an ER method, as well as providing key factors that should be addressed in its application. Meanwhile, due to the limitations of these studies, more well-designed studies are still needed.
The influence of strong social ties on the choice of long-term care model for middle-aged and older adults in China
Authors: Jing Tao , Zhao Xinmeng , Xing Huixia , Bao Chuang , Zhan Lanxi
Published: May 2023

With the acceleration of population aging in China, the care of middle-aged and older adults has become the focus of social attention. As China is an “acquaintance society,” strong social relations play an important role in residents’ access to information and resource allocation, which has an impact on the choice of long-term care models for middle-aged and older adults. Therefore, based on the 19,728 samples from the 2018 CHARLS Phase I data, an empirical analysis was conducted using a logistic dichotomous model, which showed that both kinship (p < 0.01) and friendship (p < 0.01) among social relationships positively influenced the choice of social care models for middle-aged and older adults. The analysis of the heterogeneity showed that the choice of long-term care models was significantly influenced by strong social relationships in the central and western regions and rural areas (p < 0.01). On the basis of this, the transmission mechanism of strong social relationships was further analyzed in conjunction with the further construction of the SIRS Contagion Model, which was used to describe the information transmission process. The results showed that residents who attached importance to strong social ties were more likely to incur medical transfer expenditure, thus further increasing their own demand for the formal care model. The policy implications of this study are to promote the coordinated development of long-term formal care and strong social relations, to further promote the socialization of the formal care model while relying on traditional family care, and to build a multi-level and diversified long-term care system for middle-aged and older adults.
MPH Capstone experiences: promising practices and lessons learned
Authors: Landfried Meg , Chen Elizabeth , Savelli Lindsay Bau , Cooper Morgan , Price Brittany Nicole , Emmerling Dane
Published: May 2023

To ensure workforce readiness, graduate-level public health training programs must prepare students to collaborate with communities on improving public health practice and tools. The Council on Education for Public Health (CEPH) requires Master of Public Health (MPH) students to complete an Integrative Learning Experience (ILE) at the end of their program of study that yields a high-quality written product demonstrating synthesis of competencies. CEPH suggests written products ideally be “developed and delivered in a manner that is useful to external stakeholders, such as non-profit or governmental organizations.” However, there are limited examples of the ILE pedagogies and practices most likely to yield mutual benefit for students and community partners. To address this gap, we describe a community-led, year-long, group-based ILE for MPH students, called Capstone. This service-learning course aims to (1) increase capacity of students and partner organizations to address public health issues and promote health equity; (2) create new or improved public health resources, programs, services, and policies that promote health equity; (3) enhance student preparedness and marketability for careers in public health; and (4) strengthen campus-community partnerships. Since 2009, 127 Capstone teams affiliated with the Department of Health Behavior at the Gillings School of Global Public Health at The University of North Carolina at Chapel Hill have worked with seventy-nine partner organizations to provide over 103,000 h of in-kind service and produce 635 unique products or “deliverables.” This paper describes key promising practices of Capstone, specifically its staffing model; approach to project recruitment, selection, and matching; course format; and assignments. Using course evaluation data, we summarize student and community partner outcomes. Next, we share lessons learned from 13 years of program implementation and future directions for continuing to maximize student and community partner benefits. Finally, we provide recommendations for other programs interested in replicating the Capstone model.
Transmission of Mycobacterium tuberculosis in schools: a molecular epidemiological study using whole-genome sequencing in Guangzhou, China
Authors: Lin Ying , Du Yuhua , Shen Hongcheng , Guo Yangfeng , Wang Ting , Lai Keng , Zhang Danni , Zheng Guangmin , Wu Guifeng , Lei Yu , Liu Jianxiong
Published: May 2023

Background

China is a country with a high burden of tuberculosis (TB). TB outbreaks are frequent in schools. Thus, understanding the transmission patterns is crucial for controlling TB.

Method

In this genomic epidemiological study, the conventional epidemiological survey data combined with whole-genome sequencing was used to assess the genotypic distribution and transmission characteristics of Mycobacterium tuberculosis strains isolated from patients with TB attending schools during 2015 to 2019 in Guangzhou, China.

Result

The TB incidence was mainly concentrated in regular secondary schools and technical and vocational schools. The incidence of drug resistance among the students was 16.30% (22/135). The phylogenetic tree showed that 79.26% (107/135) and 20.74% (28/135) of the strains belonged to lineage 2 (Beijing genotype) and lineage 4 (Euro-American genotype), respectively. Among the 135 isolates, five clusters with genomic distance within 12 single nucleotide polymorphisms were identified; these clusters included 10 strains, accounting for an overall clustering rate of 7.4% (10/135), which showed a much lower transmission index. The distance between the home or school address and the interval time of symptom onset or diagnosis indicated that campus dissemination and community dissemination may be existed both, and community dissemination is the main.

Conclusion and recommendation

TB cases in Guangzhou schools were mainly disseminated and predominantly originated from community transmission. Accordingly, surveillance needs to be strengthened to stop the spread of TB in schools.
Association between long-term exposure to ambient particulate matter and pulmonary function among men and women in typical areas of South and North China
Authors: Liu Qihang , Pan Li , Yang Ting , Ou Qiong , Sun Zhiwei , He Huijing , Hu Yaoda , Tu Ji , Lin Binbin , Lao Miaochan , Liu Chang , Li Baicun , Fan Yajiao , Niu Hongtao , Wang Longlong , Shan Guangliang
Published: May 2023

Background

Studies comparing the effects of different sizes and concentrations of ambient particulate matter (PM) on pulmonary function in different regions and sexes remain sparse.

Objectives

To investigate the associations of different sizes and levels of long-term ambient PM exposure with pulmonary function among people of different sexes in typical areas of South and North China.

Methods

In 2021, a total of 1,592 participants aged 20–73 years were recruited to participate in the pulmonary function test from the baseline survey of the Diverse Life-Course Cohort (DLCC) in typical areas of Guangdong Province and Hebei Province. The three-year (2018–2020) average ambient PM concentrations were assessed from the ChinaHighPM1 dataset, ChinaHighPM2.5 dataset and ChinaHighPM10 dataset. Mean differences in pulmonary function were used in multilevel models for different regions and sexes.

Results

We discovered significant associations of ambient PM exposure with reduced forced vital capacity (FVC) and increased forced expiratory volume in 1 s/forced vital capacity ratio (FEV1/FVC) among men and lower levels of FEV1 and FVC among women, such that a 5-μg/m3 concentration increase in PM1, PM2.5, and PM10 was associated with decreases in FVC of 122.1 ml (95% confidence interval (CI): 30.8, 213.4), 54.6 ml (95% CI: 15.8, 93.3) and 42.9 ml (95% CI: 12.7, 73.1) and increases in FEV1/FVC of 2.2% (95% CI: 0.6, 3.9), 1.1% (95% CI: 0.4, 1.9) and 0.9% (95% CI: 0.3, 1.5) among men and decreases in FEV1 of 51.1 ml (95% CI: 9.7, 92.4), 21.6 ml (95% CI: 4.3, 38.9) and 16.7 ml (95% CI: 3.3, 30.1) and in FVC of 77.8 ml (95% CI: 10.0, 145.6), 38.7 ml (95% CI: 9.0, 68.5) and 31.1 ml (95% CI: 8.1, 54.1) among women in Hebei Province. There was no association between ambient PM and pulmonary function in Guangdong Province.

Conclusion

Long-term exposure to different sizes and concentrations of ambient PM were associated with FEV1 and FVC among men and women differently. The impact of ambient PM on FVC should be of greater concerned.