bluuebunny/crossref_metadata_2025 huggingface dataset:
Female Sexual Function in Different Phenotypes of Polycystic Ovarian Syndrome: A Comparative Cross-sectional Study
Authors: Yarjanli Mahsa , Sadatmahalleh Shahideh Jahanian , mirzaei negin , Azarbajani Khadijeh
Published: April 2022

Background
Polycystic ovary syndrome (PCOS) coexisting mood disorders along with a combination of aesthetic manifestations may have a detrimental effect on women's sexual function. Hence, different phenotypes of PCOS have different clinical and biochemical signs and symptoms. The aim of this study was to compare women's sexual function (SF) in different phenotypes of PCOS.
Methods
This cross-sectional study was conducted on 364 women who met the Rotterdam diagnostic criteria to compare different PCOS phenotypes (A = 95, B = 78, C = 95, and D = 95). All patients were invited to fill out the female sexual function index (FSFI).
Results
Significant differences were observed between the different phenotypes in terms of the total score, sexual desire, arousal, lubrication, and satisfaction (P < 0.001); however, no significant differences were found between them in the terms of pain (P > 0.05) and orgasm (P > 0.05). In addition, phenotype B had the lowest mean score of total FSFI (P < 0.05).
Conclusion
The results indicated that women's SF is significantly different in different PCOS phenotypes. It is concluded that in order to solve the SF problems of women with PCOS, different treatment and care measures should be considered according to the relevant phenotype.
Quality of life of Japanese women with dysmenorrhea and/or heavy menstrual bleeding treated with levonorgestrel intrauterine delivery system in a real-world setting
Authors: Momoeda Mikio , Akira Shigeo , Harada Tasuku , Kitawaki Jo , Maeda Nagamasa , Ota Ikuko , Yoshihara Keisuke , Takahashi Noriko
Published: April 2022

Background: The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (QOL) of Japanese women over the course of the investigational period.Methods: This was a multicenter, non-interventional, prospective, single-cohort, post-marketing surveillance study (J-MIRAI). The primary outcome was the median change in the Menstrual Distress Questionnaire (MDQ) and Menorrhagia Multi-Attribute Scale (MMAS) scores from baseline to 3 and 12 months after LNG-IUS insertion, with decreasing and increasing scores, respectively, indicating improvement. The secondary outcomes were the statistical relationships between the MDQ and menstrual pain, and between the MMAS and pictorial blood loss assessment chart (PBAC) scores by regression analysis.Results: In total, 593 patients were evaluated; 376, 467, and 250 patients were diagnosed with dysmenorrhea, HMB, or both, respectively. The median MDQ score decreased significantly at 3 and 12 months after LNG-IUS insertion in both the premenstrual and menstrual periods (both p < 0.001 vs baseline), and the median MMAS score showed a similar improvement during the menstrual period. Changes in median MDQ and MMAS scores were observed regardless of patient background. Correlations between MDQ and menstrual pain and between MMAS and PBAC scores were found (estimated regression coefficients: 0.29 and −0.15, respectively).Conclusion: The LNG-IUS contributed to improvements in the QOL of patients with dysmenorrhea, HMB, and both, regardless of patient background characteristics.Trial registration: Registered at ClinicalTrials.gov (NCT02475356) on 18 June 2015.
Association between fraudulent financial reporting, readability of annual reports, and abusive earnings management: A case of Indonesia
Authors: Tarjo Tarjo , Anggono Alexander , Prasetyono Prasetyono , Yuliana Rita , Sakti Eklamsia
Published: April 2022

In practice, auditors sometimes have a hard time detecting false financial statements since they only look at the figures on the financial statements. Consequently, they ignore the red flags in the annual reports’ wording. This study aims to analyze how the level of readability of annual reports and abusive earnings management affects fraudulent financial reporting. A total of 240 annual reports from publicly traded industrial businesses were used. The paper used data from the Indonesia Stock Exchange (IDX) and each sampled companies’ official website. A multiple linear regression analysis was used to test the hypotheses. Falsified financial statements are the dependent variable, while annual report readability and abusive earnings management are independent variables. The Dechow F-Score is used to assess whether financial statements are false. The annual report’s readability is assessed using the Flesch Reading Ease, Length, Flesch-Kincaid, and Lasbarhets Indexes. Finally, accrual discretionary and real earnings management are used to uncover earnings management misuse. According to the findings, dishonest earnings management has a significant influence on financial statement fraud. Moreover, abusive earnings management can aid in the detection of falsified financial statements. AcknowledgmentsRector Universitas Trunojoyo Madura supported this paper under Grant Number 2285/UN46.3.1/PN/2019. Any and all views, results, conclusions, or recommendations stated in this material are solely those of the author(s) and do not necessarily reflect those of Universitas Trunojoyo Madura. The authors would like to express their gratitude to the Rector of Universitas Trunojoyo Madura for his efforts and cooperation in conducting this investigation.
The impact of perceived effectiveness of performance management system on affective commitment: Employee participation as a moderator
Authors: Waladali Emad
Published: April 2022

Palestinian companies nowadays realize the importance of performance management systems. This study examines the moderating effect of employee participation in the relationship between perceived effectiveness of performance management system and affective commitment of employees in Palestinian service companies. A questionnaire was designed using Google Docs and distributed randomly via e-mail among 174 employees working in Palestinian service companies. A structural equation modeling, using AMOS V26, was used to test the hypotheses. The findings showed that perceived effectiveness of performance management system has a significant positive impact on affective commitment (β = 0.77; p-value = 0.000). While the justice dimension of perceived effectiveness of performance management system has a significant positive impact on affective commitment (β = 0.52; p-value = 0.007), the accuracy dimension was found insignificant (β = 0.26; p-value = 0.178).Regarding the moderating effect, neither the interaction between the perceived effectiveness of performance management system and employee participation (β = –0.031; p-value = 0.465) nor the justice dimension was significant (β = 0.103; p-value = 0.203). Nevertheless, the interaction between the accuracy dimension and employee participation was negative (β = –0.14; p-value = 0.034). This study yielded support for the importance of perceived effectiveness of performance management system. Employees who perceived the performance of management system to be effective have higher affective commitment. Therefore, managers, especially HR managers, in service companies should pay more attention to the perceived effectiveness of performance management system, especially its justice dimension, to gain the benefits of committed employees.
ESTUDO DA ATIVIDADE ANTITUMORAL DE UM NOVO COMPLEXO DE RU3+: UMA PROPOSTA PARA O DESIGN DE METALOFÁRMACOS DE BAIXA TOXICIDADE
Authors: Andrade Maria Helena , Aguiar Jaciana , Silva Teresinha , Santos Jandyson , Silva Wagner , Belian Mônica F. Belian
Published: April 2022

STUDY OF THE ANTITUMORAL ACTIVITY OF A NEW Ru3+ COMPLEX: A PROPOSAL FOR THE METALOPHARMACEUTICAL DESIGN OF LOW TOXICITY. In this article the synthesis, characterization, acute toxicity, and antitumor activity of the novel Ru3+ complex are described. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol guideline 423. The cisplatin complex was classified in category 1 and the sodium diaquodimalonateruthenate(3+) - Na[Ru(H2O)2(Mal-κ2 O)2] – was classified in category 4. This result demonstrates the lower toxicity achieved by the ruthenium complex in comparison with metallopharmaceuticals compound. Evaluations of tumor masses extracted from mice inoculated with Ehrlich ascites carcinoma demonstrated percent inhibition lowest to cisplatin. Cisplatin showed 58% inhibition (1 mg/kg), while Na[Ru(H2O)2(Mal-κ2O)2] complex (5 mg/kg) presented 77%.
PERFIL SOCIOECONÔMICO DE ESTUDANTES DE QUÍMICA: O CASO DOS CURSOS DA UNESP – ARARAQUARA
Authors: Agostini Gabriela , Nascimento Matheus , Massi Luciana
Published: April 2022

SOCIOECONOMIC PROFILE OF UNDERGRADUATE CHEMISTRY STUDENTS: THE CASE OF UNESP-ARARAQUARA COURSES. Considering the recent expansion and democratization of access to Higher Education in Brazil, this article aims to characterize and compare the socioeconomic profiles of students who are entering the Bachelor (BAC), teacher education degree (LIC) and Chemical Engineering (ENG) at UNESP - Araraquara. A quantitative, longitudinal study was performed according to sociological interpretation of Pierre Bourdieu. The data stands for a socioeconomic questionnaire and the performance on the entrance exam of 1544 students between 2003 and 2018. A Socioeconomic Index was built through a Factorial Analysis and a Multiple Correspondence Analysis was performed to compare he profile of students of three courses. The results show that the students’ profiles are different, despite becoming similar in recent years, and the demand for these courses has been decreasing since 2016. There are three factors that explain these changes: i) young people’s lack of interest in scientific careers; ii) low attractiveness of the teaching career; iii) the creation of a new course modality in the institution (the ENG). Studies like this can contribute to identify, evaluate, and implement actions to democratize the access and permanence of students in Higher Education.
One-Pot Separation and Preconcentration for the Determination of Chromium Species Using an Aqueous Biphasic System
Authors: Patrício Pamela , Quintão Juan , da Silva Luis , Hespanhol Maria
Published: April 2022

The widespread use of the trace metal chromium in industrial processes and the known toxicity of CrVI species have stimulated interest in chromium speciation analysis. However, some analytical detection systems are not suitable for the quantification of CrIII and CrVI species. In the present study, an aqueous biphasic system (ABS) was employed as an environmentally safe, simple, and economical alternative. The ABS allows the implementation of an efficient separation step before quantifying of the species of interest by flame atomic absorption spectrometry. A robust speciation and preconcentration method was developed, which can be applied to samples with a wide concentration range, without the use of any extractants and interconversion of the species during the procedure. The proposed method was successfully used to determine the chromium species present in tap, treatment plant, river, and electroplating wastewater samples. Recovery percentages of 87.9-107% were achieved, suggesting minor water matrix interference. The proposed method had acceptable limits of detection and quantification of 5.38 and 16.3 μg kg-1, respectively.
Athar Istīʿāb al-Mufradāt wa-al-Qawāʿid ʿalá Kafā’at al-Kitābah al-Imlā’īyah li-al-Talāmīdh fī al-Faṣl al-Thāmin bi-Madrasat Al-Waṭanīyah al-Thānawīyah al-Islāmīyah Kebumen
Authors: Niswah Fiki Khoerun , Hadjar Ibnu , Shiddiq Mahfudz
Published: April 2022

Many students at Wathoniyah Islamiyah Junior High School (Madrasah Tsanawiyah) Kebumen graduated from public elementary schools, so many had not have adequate knowledge of the Arabic language. This study is essential because students' diverse vocabulary and grammatical comprehension influenced their writing and spelling ability. The current study investigates the influence of vocabulary and grammatical comprehension on eighth grade students' spelling writing abilities at Wathoniyah Islamiyah Kebumen. All eighth-grade students at Wathoniyah Islamiyah Junior High School were recruited in this research. The study employed a quantitative design and purposive sampling technique to test the sample. The researchers obtained the data using documentation and analyzed the data using multiple regression tests. The results indicated that the F value is 11.250, and the F table with the value from the table at a 5% significance level = 3.385. Therefore, the F count exceeds the F table. The findings also indicated that the students' vocabulary and grammatical knowledge and comprehension have a substantial influence on their spelling and writing skill. Therefore, the research hypothesis is acceptable.
Caminhos para a inserção da Natureza da Ciência na Educação Básica: alguns resultados de pesquisa a partir de uma disciplina na Licenciatura de Física
Authors:   UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL, Teresinha Massoni Neusa , Araújo Carvalho Felipe de ,   Instituto Federal de Educação, Ciêcnia e Tecnologia do Paraná
Published: April 2022

Este artigo apresenta resultados de uma pesquisa desenvolvida no âmbito de um mestrado acadêmico, a partir da observação e inserção do pesquisador nas aulas de uma disciplina de História da Física e Epistemologia (HFE), na licenciatura em Física de uma universidade pública do sul do Brasil. A disciplina discute a natureza da ciência (NdC) articulada com a história da Física/Ciência (HC). O objetivo deste trabalho foi investigar o papel de microepisódios de ensino, que são microaulas que agregam elementos da NdC, realizados no final da disciplina, visando instrumentalizar os licenciandos a levarem esse debate para a Educação Básica. A investigação se insere em uma linha cuja tese vertebradora é de que a NdC pode contribuir para a melhoria da aprendizagem da Física e para a promoção de uma educação científica reflexiva e cidadã. O referencial epistemológico e metodológico de Bruno Latour (2012) ofereceu suporte à construção de um “relato de risco” em que foram valorizadas as narrativas pessoais dos sujeitos de pesquisa buscando identificar os desafios que a integração da HFE ao ensino de Física vai colocando ao longo da formação inicial; cada elemento identificado foi tomado como “nó” de uma rede complexa – noção de ator-rede – que, ao ser rastreada, revela diferentes percepções e associações que fornecem indícios para uma melhor compreensão do porquê a NdC ainda não chega de forma explícita na educação científica.
Geochemical stream sediment signatures from Precambrian terrains of Uruguay
Authors: Filippini-Alba José Maria
Published: April 2022

Geochemical data of Uruguayan crystalline terrains collected in the 80’s were recovered by the National Mining and Geology Directorate of Uruguay (DINAMIGE) in 2020 involving 32,000 soil and stream sediment samples analyzed for 22 elements (Ag, As, B, Ba, Be, Cd, Co, Cr, Cu, Fe, Mn, Mo, Nb, Ni, P, Pb, Sb, Sn, V, W, Y and Zn) by direct current plasma spectrometry. A set of 6755 samples of these data, more or less 21% of the total, were processed by multivariate statistical methods and geographic information system (GIS) procedures aiming characterization of geochemical signatures derived from environmental and geological processes. Samples were classified as background or anomalies/outliers at the beginning. The general data and the different sets were processed by statistical methods and GIS individually. The results considered the original units or sometimes, the transformed data for uniformity of variability. Nine geochemical signatures related to the geological domains were defined; three of them involved low contrast units with moderate enrichment in Ba, Co, Cu or Mn. The remaining six geochemical signatures were related to specific geological units and presented multivariate signatures. Seven signatures related to anomalies were defined, three of them of lithological origin, two superficial and the others mixed, including the possibility of sulphide deposits.
Identification of Hub Genes and Biomarkers between Hyperandrogen and
Normoandrogen Polycystic Ovary Syndrome by Bioinformatics Analysis
Authors: Li Xiaodong , Hu Baoshan , Zhang Tianwei , Liu Yang
Published: April 2022

Background:

The common and divergent genetic mechanisms of hyperandrogen (HA)
and normoandrogen (NA) polycystic ovary syndrome (PCOS) are currently unknown.

Objective:

This study aimed to explore the hub genes and potential mechanisms of HA and NA
PCOS through bioinformatics analysis.

Methods:

The GSE137684 dataset was downloaded from the Gene Expression Omnibus (GEO)
database. The co-expressed genes and differentially expressed genes (DEGs) between HA and NA
PCOS samples were functionally annotated by gene ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) enrichment analyses. The protein-protein interaction (PPI) network
of the DEGs was constructed and visualized using STRING and Cytoscape, respectively, and the
hub genes were screened using the Cytohubba plug-in. The transcription factors (TFs) of these hub
genes were identified with the JASPAR database, and the hub gene-TF regulatory network was
constructed.

Results:

A total of 327 DEGs, including 191 upregulated and 136 downregulated genes, were identified
in HA PCOS relative to NA PCOS. Ten hub genes were screened, of which MYC, CAV1,
and HGF were mainly enriched in the Proteoglycans in the cancer pathway. In addition, 47 TFs
were identified that were found to be involved in the regulation of hub genes.

Conclusion:

MYC, CAV1, and HGF are potential diagnostic biomarkers and therapeutic targets for HA
PCOS.
WITHDRAWN: Recent Advances of Nanotechnology in the Treatment of Skin Cancer
Authors: Kanugo Abhishek
Published: April 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
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Is the Alzheimer's Disease Assessment Scale-Cognitive Subscale Useful in
Screening for Mild Cognitive Impairment and Alzheimer's Disease? A
Systematic Review
Authors: Park Seong-Hi , Han Kuem Sun
Published: April 2022

Background:

Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) are
screened to distinguish whether the cognitive decline in older adults is attributed to pathological
causes rather than normal aging.

Objective:

The purpose of this review was to analyze the diagnostic performance of the Alzheimer's
Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in screening for MCI and AD.

Methods:

Electronic searches were performed on MEDLINE, EMBASE, CINAHL, and PsycArticles
databases using the following keywords: dementia and ADAS-Cog. The Quality Assessment of Diagnostic
Accuracy Studies-2 was used to check the risk of bias in the diagnostic studies.

Results:

We reviewed 14 studies, including 3,875 patients who met the selection criteria. In 2,624
MCI patients from nine studies, the pooled sensitivity of ADAS-Cog was 0.80 (95% confidence interval
[CI], 0.68–0.88), the pooled specificity was 0.84 (95% CI, 0.75–0.90), and the area under the
curve of summary receiver-operating characteristic curves (SROC AUC) was 0.89 (SE = 0.03). In
2,517 AD patients from 10 studies, the pooled sensitivity and pooled specificity were 0.91 (95% CI,
0.86–0.95) and 0.93 (95% CI, 0.88–0.95), respectively, and the sROC AUC was 0.97 (SE = 0.01).
Although sub-analyzed according to age and years of education, there was no significant difference
in the predictive validity of the ADAS-Cog.

Conclusion:

The ADAS-Cog has high predictive validity as a screening tool in both MCI and AD
and has better diagnostic performance in patients with AD. When early screening for AD is desired,
ADAS-Cog is a first-stage screening tool that can be initially employed.
Fibrolipoma of the Median Nerve: An Overview
Authors: Slouma Maroua , Zarrouk Zeineb , Maatoug Feten , Dhahri Rim , Amorri Wajdi , Gharsallah Imen , Metoui Leila , Louzir Bassem
Published: April 2022

Introduction:

Fibrolipoma of the median nerve is a rare benign lesion responsible for carpal tunnel syndrome. Fibrolipoma is often misdiagnosed. This article aimed to review and summarize current knowledge regarding fibrolipoma of the median nerve. We emphasize the clinical and imaging features of this disease.

Methods:

To examine the characteristics of fibrolipoma of the median nerve, we performed a litera-ture review using MEDLINE. The search included only English studies published from database in-ception to June 2021.

Results:

Forty-six cases of fibrolipoma of the median nerve were included.
Fibolipoma is characterized by diffuse infiltration of peripheral nerves by normal-appearing fibrous and adipose tissues. The fibrolipoma of the median nerve can be responsible for macrodactyly, numbness, paresthesia, and weakness within the median nerve distribution. Ultrasonography shows a fusiform hyperechoic mass along the nerve containing hypoechoic bands corresponding to nerve fascicles.
Magnetic resonance imaging is the gold standard for the diagnosis of fibrolipoma. It typically shows a contrast between the low signal nerve fibers and the high signal fatty tissues, revealing a charac-teristic « cable-like » appearance on axial sections and a «spaghetti-like» appearance on coronal sections.

Conclusion:

Fibrolipoma should be considered in young patients with carpal tunnel syndrome. This review emphasizes the clinical and radiological features of fibrolipoma. We highlight the images of ultrasonography in the diagnosis of rare structural causes of carpal tunnel syndrome.
Assessment of Lumbar Vertebrae Morphology by Computed Tomography
in Older Adults with Osteoporosis
Authors: Lin Chun-Li , Liao Chi-Yang , Chien Chia-Liang , Pu Ta-Wei , Shen Shin-Chieh , Yang Chien-Yi , Yen Ching-Heng
Published: April 2022

Background:

Hounsfield units (HU) values derived from computerized tomography (CT)
have been used in the diagnosis of osteoporosis in the lumbar spine.

Objective:

This study aimed to identify anatomical dimensions of lumbar vertebrae on CT images,
which were different between older normal, osteopenic, and osteoporotic subjects.

Methods:

This prospective pilot study enrolled 79 older adults. Based on CT measurements of lumbar
vertebrae in HU, participants were classified into three groups: normal (HU > 109), osteopenia (HU:
94-108), and osteoporosis (HU < 93). Altogether, 42 anatomical variables of lumbar vertebrae, L2, L3,
L4, and L5, were measured in each participant by CT, including 24 parameters measurable by MRI or
plain X-ray and 18 parameters measurable by MRI only.

Results:

Among the morphological measurements also measurable by MRI and plain X-ray, the length
upper curve, 50% and 75% of L5, length upper with the cortex of L4, length center of the cortex of L3,
as well as width upper curve 75% of L2, were significantly different between the three groups (p=
0.008, 0.007, 0.035, 0.036, and 0.003 respectively). Among the morphological measurements also
measurable by MRI, only the width upper cortex 75% of L5 and the width lower cortex 25% of L3,
were significantly different between the three groups (p= 0.031 and 0.020, respectively).

Conclusion:

Seven CT morphological measurements may be used as “reference standard” CT measurements
for preliminarily diagnosing osteoporosis and osteopenia in older adults.
Clinical Characterizations and Radiological Findings of COVID-19: A 4
Case Report
Authors: Ye Aihua , Hu Chunhong , Qiao Zhenguo , Liu Dong , Fu Fangfang
Published: April 2022

Background:

Coronavirus disease 2019 (COVID-19, previously known as novel coronavirus
[2019-nCoV]), first reported in China, has now been declared a global health emergency by
World Health Organization. The clinical severity ranges from asymptomatic individuals to death. Here,
we report clinical features and radiological changes of a cured family cluster infected with COVID-19.

Case Presentation:

In this report, we enrolled a family of 4 members who were admitted to our hospital
in January 2020. We performed a detailed analysis of each patient’s records. All patients underwent
chest computed tomography (CT) examination with 120 kilovolts peak and 150 kilovolt-ampere. Realtime
polymerase chain reaction (RT-PCR) examinations for severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) nucleic acid were done using nasopharyngeal swabs.

Conclusion:

In the family members infected with COVID-19 who were accompanied by other diseases
or had low immunity, the pneumonia was prone to be aggravated.
Low-dose COVID-19 CT Image Denoising Using CNN and its Method
Noise Thresholding
Authors: Singh Prabhishek , Diwakar Manoj , Pandey Neeraj Kumar , Singh Ravinder , Sisodia Dilip , Arya Chandrakala , Chakraborty Chinmay
Published: April 2022

Noise in computed tomography (CT) images may occur due to low radiation doses. Hence,
the main aim of this paper is to reduce the noise from low-dose CT images so that the risk of high radiation
dose can be reduced.

Background:

The novel coronavirus outbreak has ushered in different new areas of research in medical
instrumentation and technology. Medical diagnostics and imaging are one of the ways in which the
area and level of infection can be detected.

Objective:

COVID-19 attacks people with less immunity, so infants, kids, and pregnant women are
more vulnerable to the infection. So, they need to undergo CT scanning to find the infection level. But
the high radiation diagnostic is also fatal for them, so the intensity of radiation needs to be reduced
significantly, which may generate the noise in the CT images.

Method:

This paper introduces a new denoising technique for low-dose Covid-19 CT images using a
convolution neural network (CNN) and noise-based thresholding method. The major concern of the
methodology for reducing the risk associated with radiation while diagnosing.

Results:

The results are evaluated visually and using standard performance metrics. From comparative
analysis, it was observed that proposed works give better outcomes.

Conclusions:

The proposed low-dose COVID-19 CT image denoising model is therefore concluded to
have a better potential to be effective in various pragmatic medical image processing applications in
noise suppression and clinical edge preservation.
Phenolic Compounds and Antioxidant and Antimicrobial Activities of
Pulicaria Odora Extract
Authors: Saidani Karima , Touati Naima , Merzouk Hafida , Boussaa Halim , Bedjou Fatiha , Oomah B. Dave
Published: April 2022

Background:

Asteraceae family, of which Pulicaria genus, plays a remarkable role in the development of drugs used in modern medicine. Leaf extracts of Pulicaria odora harvested in Bejaia were evaluated for their antioxidant and antimicrobial activities.

Methods:

HCl method at three different wavelengths 280, 320 and 360 nm was carried out for total phenolics content and characterized by ultra-performance liquid chromatography (UPLC) analysis. Antimicrobial activity was evaluated using four bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Listeria innocua) and three molds (Aspergillus flavus, Aspergillus niger and Trichoderma reesei). Four antioxidant tests (ORAC, ABTS, DPPH and FRAP) were performed.

Results:

The extracts had high total polyphenols (305 mg catechin equivalents [CE]), flavonols (56 mg quercetin equivalents [QE]), tannins (77 mg CE) and tartaric acids (38 mg caffeic acid equivalents [CAE]) per g dry matter contents. UPLC analysis of the 70 % ethanol extracts showed abundant phenolic acids (protocatechuic, chlorogenic and caffeic acids). Pulicaria odora extracts exhibited good antimicrobial activity against bacterial (~18 mm inhibition zones) and molds (11.3-17.3 mm) strains.

Conclusion:

All extracts displayed good antioxidant activity and effective antimicrobial activity, which allow its use as a conservative agent or therapeutic remedy.
Repurposing of Various Current Medicines as Radioprotective Agents
Authors: Kaur Rajwinder , Lang Damanpreet Kaur , Singh Harwinder , Arora Arpita , Garg Nikhil , Saini Balraj
Published: April 2022

Background:

The side effects of ionising radiation include skin changes, dry mouth, hair loss, low blood
count, and the mutagenic effect on normal cells when utilized in radiotherapy for cancer treatment. These radiations
can cause damage to the cell membrane, lipids, proteins, and DNA and generate free radicals. Evidence reports stated
that radiotherapy accounts for 17-19% of secondary malignancies, labelling this treatment option a double-edged
sword.

Objective:

Radioprotective molecules are used for mitigating radiotherapy's side effects. These agents show free radical
scavenging, antioxidant, collagen synthesis inhibition, protease inhibition, immune stimulation, increased cytokine
production, electron transfer, and toxicity reduction properties. The most frequently used amifostine has an array of
cancer applications, showing multitarget action as nephroprotective to cisplatin and reducing the chances of xerostomia.
Many other agents, such as metformin, edaravone, mercaptopropionylglycine, in specific diseases, such as diabetes,
cerebral infarction, cystinuria, have shown radioprotective action. This article will discuss potentially repurposed
radioprotectors that can be used in the clinical setting, along with a brief discussion on specific synthetic agents like
amifostine and PrC-210.

Methods:

Rigorous literature search using various electronic databases, such as PubMed, ScienceDirect, Scopus,
EMBASE, Bentham Science, Cochrane Library, etc., was made. Peer-review research and review papers were selected,
studied, reviewed, and analysed.

Conclusion:

Safety and risk-free treatment can be guaranteed with the repurposed agents. Agents like metformin,
captopril, nifedipine, simvastatin, and various others have shown potent radioprotective action in various studies. This
review compiled repurposed synthetic radioprotective agents.
Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective
Agent
Authors: Joshi Shivanki , Dhingra Ashwani K. , Chopra Bhawna , Guarve Kumar , Bhateja Deepak
Published: April 2022

Background:

Neuroprotection is preserving neural function in various neurodegenerative
diseases like Alzheimer’s, Huntington’s, Parkinson’s, and multiple sclerosis. Hesperidin, a flavanone
glycoside in citrus fruits such as sweet oranges and lemons, possesses many biological effects, including
neuroprotection.

Objective:

The study aims to explore the neuropharmacological mechanisms and therapeutic potential
of hesperidin in the management of neurodegenerative disorders.

Method:

It emphasizes comparative and clinical trial studies with a number of targets reviewed from
the data available on PubMed, Science Direct, Clinicaltrails.gov, and from many reputed foundations.

Result:

Escalating clinical evidence has established the inhibitory effect of hesperidin in the management
of neurodegenerative disorders. Neuroprotective potential of hesperidin is characterized by
endogenous antioxidant defence functions, improvement of neural growth factors, antineuroinflammatory
activity, and apoptotic pathways.

Conclusion:

The present study highlights the beneficial neuropharmacological potential of hesperidin,
including anticonvulsant, antidepressant, antioxidant, anti-inflammatory, memory, and locomotor enhancing
activities.
Medicinal Importance, Pharmacological Activities and Analytical Aspects
of a Flavonoid Glycoside ‘Nicotiflorin’ in the Medicine
Authors: Patel Dinesh Kumar
Published: April 2022

Background:

Herbal products are derived from different natural sources, mainly used as
a source of food material and medicine in the health sectors since ancient times. Herbal products
have gained popularity in modern medicine due to their beneficial health properties and pharmacological
activities. Flavonoids are an important class of secondary metabolites found to be present in
medicinal plants and their derived products. Flavonoids have been known for their anti-allergic,
anti-bacterial, anti-diabetic, anti-inflammatory, anti-viral, anti-proliferative, anti-mutagenic, antithrombotic,
anti-carcinogenic, anti-oxidant and hepatoprotective activities in the medicine. Nicotiflorin
is a flavonoidal class phytochemical, found in medicinal plants, including Traditional Chinese
medicine.

Methods:

Scientific data on the medicinal importance and pharmacological activities of nicotiflorin
have been collected and analyzed in the present work in order to know the therapeutic importance
of nicotiflorin in medicine. Scientific data have been collected from Google, Google
Scholar, Science Direct, PubMed and Scopus and analyzed in the present work. Analytical techniques
data of separation, isolation and identification of nicotiflorin have also been collected and
presented in the current work. Further biological importance of flavonoidal class phytochemicals
was also discussed in the present work to understand the biological importance of nicotiflorin in
medicine as it belongs to the flavonoid class.

Results:

Scientific data analysis revealed the therapeutic importance and pharmacological activities
of nicotiflorin. Nicotiflorin has significant biological potential against coronavirus, ischemia,
renal impairment, hepatic complication, memory dysfunction and myocardial infarction. The biological
potential of nicotiflorin against α-glucosidase and α-amylase enzymes, multiple myeloma
cells and insulin secretion has also been discussed in the present work. Analytical data revealed the
significance of modern analytical tools in medicine for the isolation, separation and quantification
of nicotiflorin.

Conclusion:

Scientific data analysis of different research works revealed the biological importance
and therapeutic potential of nicotiflorin in medicine.
Antibacterial and Phagocytic Properties of a Novel Silver-Interferon
Complex
Authors: Plotnikov Evgenii , Plotnikov Vladimir
Published: April 2022

Background:

Developing new antibacterial and antiviral drugs are considered a significant issue due to the emergence and spread of resistant strains of microorganisms. The COVID-19 pandemic has dramatically increased the need for new broad-spectrum anti-infective agents.

Objective:

This experimental study aimed to investigate the antibacterial and phagocytic properties of silver-interferon preparation. The combination of properties of complex drugs makes them promising for treating drug-resistant infections and bacterial complications of viral diseases.

Method:

The antibacterial effect of the silver-interferon platform was investigated by agar diffusion and serial dilution methods. The drug's effect on the functional activity of phagocytes was studied on human neutrophils in a Staphylococcus aureus uptake test.

Results:

Investigations have shown that the silver-interferon complex possesses a bactericidal mechanism of action against tested bacterial strains, including Streptococcus pneumonia, Salmonella enteritidis, Staphylococcus aureus, Escherichia coli. Streptococcus pneumonia was the most susceptible bacterial target for the tested complex, with a growth inhibition zone of 12±0.6 mm and a minimal bactericidal concentration of 0.08 mg/ml. A slight stimulating action of the drug in relation to the activity of phagocytes was revealed.

Conclusion:

Silver-interferon has proved as a prospective anti-infective drug with a wide range of activities.
Pineapple Natural Fibre Composite: Extraction, Mechanical Properties and Application
Authors: Kohli A.
Published: April 2022

In the present scenario, one out of every five persons on the globe suffers from osteoporosis and other bone-related disorders. This disease has no age restrictions and can strike anybody between the ages of 10 and 100, even newborns. The aforementioned concerns are the consequence of lifestyle disorders as well as damage to the body, which affects the concerned person's body internally, resulting in the aforementioned issues as well as a shortage of Vitamin D. As a result, crutches and other rehabilitation items are in high demand. The above tools are often composed of wood, aluminium, or a steel/aluminum alloy, with Nylon 6/6 cuffs in the case of crutches. Many trees are felt as a result of the creation of such instruments. There is also a significant carbon footprint. As a result, an alternate material for the same purposes is required. Taking cues from the aforementioned issue and waste material in the sphere of residential trash, a PALF composite was identified due to its ease of availability as well as its superior quality and mechanical qualities.
Next Generation Biodegradable Material for Dental Teeth and Denture base Material: Vegetable Peels as an Alternative Reinforcement in Polymethylmethacrylate (PMMA)
Authors: Kohli A.
Published: April 2022

Today, oral diseases are the most quotidian and conventional issues of the 21st Century. Further investigations about the oral disorders stated that it comprises tooth decay, mouth sores, tooth erosion, tooth sensitivity, gum diseases, toothaches, and dental emergencies are predominant in today’s generation. The further study identified that the improper bonding between the denture base and dental teeth ends up with costly repair along with mouth sores to provide relief from these problems. This effect is not age-restricted and can be observed in any age range but it is prevalent in middle age (35 years) to old age (<80 years) people in the world. Approximately one-third of the world’s population is suffering because of untreated caries of natural teeth (32.7%). The optimal composition of PMMA, organic filler materials, zinc or titanium oxides etc. as denture base, dental tooth, clinical trials with observation, and experimental methodology is yet to be unleashed to reach its optimized state for this considered problem. A call for an alternative material for denture base or the dental tooth is still an unanswered question for a long period. Selection of appropriate reinforcement material encompassing the guidelines for liquid/powder ratio, avoid processes terrible for bond strength, wax-free model. Current work focuses on the investigation of mechanical properties with or without the reinforcement of new and novel biomaterials made of epoxy with carrot peel, epoxy with onion peel, lemon peel, and epoxy with potato peel. Comparative analysis of coupons for with/without the reinforcement (in the form of Short/Continuous fiber) was investigated. The Simulation work correlated with experimental work to explore the possibilities of new material in the arena of dental.
Microstructure Characteristics of Cellulose Fibers in Cement Paste and Concrete - A Review
Authors: Habibunnisa S.
Published: April 2022

This paper explores, present scenario of using natural fibers in concrete, which are having high cellulose content. Cellulose fibers contribute the development of high-quality fiber-reinforced cement composites. In recent days natural fibers attracting many researchers due to its low cost and being largely available in nature with the comparison of artificial fibers. These are accessible in the fibrous formation and extracted from seed pods, herbal leaves, which are become trustful over the regular fibers. Sometimes construction industries also use natural plant cellulose fibers as a secondary raw material. These seem to be a good alternative resource for eco-friendly materials that can be replace the synthetic polymeric fibers. The author aim is to discuss the microstructure of concrete reinforced with cellulose fibers shows a possessive characteristic of good tensile strength and bond properties.
Durability Against Fatigue and Moisture of Natural Fibre Composite
Authors: Salahuddin B.
Published: April 2022

The development of high-performing engineering materials fabricated using constituents of natural origins is gradually increasing around the globe. In the last few decades, there have been notable research achievements in green materials science through the development of natural fibre reinforced composites (NFCs). The advantages of these materials over synthetic fibre composites support extensive range of potential applications, with added benefits of low environmental impact and inexpensive throughput. Significant effort has gone into improving their performance to extend the capabilities and applications of this materials. Although there is a range of performance limitations which can be seen from NFCs, durability against fatigue and moisture of these materials are amongst the major concerns. This chapter aims to provide an overview of the effects of fatigue and moisture on NFCs by discussing factors, testing technology and protection techniques, and their effect on the durability and performance of the composites.
Measurement of Thermal Conductivity of Natural Fiber Composites
Authors: Ramanaiah K.
Published: April 2022

The conventional materials are replaced with natural composites in energy saving applications due to their good insulation properties against heat transfer and the higher specific strength. In this chapter, the extraction of natural fibers, preparation of composites was discussed. The process of measurement of thermal conductivity of composites is elucidated. Based on the test data, natural polymer composites are promising composite materials for energy saving applications.
Advancement of Guided Tissue Regeneration (GTR) Membranes for Dental Applications
Authors: Amin N.
Published: April 2022

Periodontal disease leads to inflammation and consequently destruction of periodontium. The main aim of periodontal therapy is to minimize the inflammation by regeneration of defects. Over the past several decades, various materials as well as clinical techniques have been studied for repair and regeneration of periodontal defects. The tissue regeneration should permit proliferation of different cells in separate compartments, as four types of tissues constitute periodontium. Guided tissue regeneration (GTR) was introduced to restrict the growth of epithelium in alveolar bone space. Several barrier membranes were developed to aid in this technique which included both natural and synthetic materials. To achieve essential function of space maintenance, non-resorbable membranes were used previously with bone graft materials. Although these membranes were widely used, however they had many disadvantages which led to development of second generation (resorbable) and third generation (functional) membranes. This chapter focuses on advanced developments of biodegradable polymers for use in GTR treatment. Moreover, non-resorbable and resorbable polymeric membranes, classifications, advanced experimental research, clinical applications, and their challenges are also discussed. The composite periodontal membranes are also under research. Despite the biocompatibility and biodegradability of unreinforced barrier membranes, these are deficient in anti-bacterial properties. Therefore, barrier membranes blended with functional materials have been fabricated which exhibited more benefits. The comparison of past and recent trends of barrier membranes can guide correctly for periodontal regeneration therapy.
Innovations in social service (education) in state-church relations in the conditions of digitalization of society and pandemic
Authors:   Faculty of Humanities, Russian State Social University, Moscow, Russia, et al. Vinichenko
Published: April 2022

The purpose of the study was to identify innovative approaches to activities in the system of state-church relations in social service (education) within the framework of interaction between an Orthodox Monastery and the Russian State Social University. The interaction between St. Nicholas Chernoostrovsky Convent and Russian State Social University (RSCU) has developed from conceptual foundations to the formation of a training system for Orthodox media. This article is the first to identify innovations: implementation of a modular, continuous model for the development of orphans in modern society, combining the efforts of secular and spiritual education; unification of philosophy and worldview, both religious and cultural, in the context of the digitalization of society and pandemic restrictions; formation of a multi-vector model of education with simultaneous development in several professional (church) directions and (or) an increase in social significance; use of hybrid forms of preparation and conduct of classes in a secular and church educational environment. The strong point of the article is a systematic approach to the study of the problem and the identified innovations, which make it possible to improve social service in the context of the digitalization of society and the COVID 19 pandemic. The use of the results obtained by other researchers can serve to develop the system of state-church relations in social service (education) of different faiths.
Education and Social Mobility For Orang Asli Papua
Authors: Indonesia Alfath Bagus Panuntun El Nur
Published: April 2022

Papuan human resources are complicated due to educational barriers that make it difficult for indigenous Papuans (OAP) to achieve upward social mobility. Many factors have contributed to these educational barriers, including poverty, conflict and war, a lack of teachers, and poor infrastructure. These obstacles should be solved through the main feature of the Special Autonomy Law (SAL), namely the "special autonomy fund". Although these funds have been rolled out in Papua since 2001 to address inequality and improve OAP's human resources, their conditions have not improved significantly. This qualitative study explored the experiences of Mappi and Puncak OAPs involved in education financed by the special autonomy fund through cooperation between the government and the university. The findings revealed the positive effect of SAL on reducing educational barriers and increasing social mobility for OAPs, but there are still some areas that needed to be improved. OAPs’ experience showed that formal education was the main determining factor to upward social mobility. This article also highlighted several areas for change, such as informal education support that needed to be improved; promoting equal development in both the coast and the highlands; increased community participation; and strengthening the political will. Recommendations are also offered.