bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges and Opportunities of a Budding Vaccinologist in Low- and Middle-Income Countries (LMICs)
Authors: Ankunda Collins , Schmitt Heinz-Josef
Published: October 2023

We highlight a young vaccinologist's struggles upon returning to a resource-limited country after training abroad. Despite the urgency of vaccination against endemic, epidemic, and pandemic diseases, daunting obstacles persist. We also propose suggestions and opportunities for meeting these challenges – making vaccines and vaccination more accessible for global public health.
Efeito ansiolítico do extrato etanólico das folhas de Citrus aurantium L. em Mus musculus
Authors: Oliveira Tássyo Alax Nascimento Sampaio de , Diniz Ana Beatriz Ferreira , Melo Junior Célio Augusto Freitas , Oliveira Tássyla Nascimento Sampaio de , Affonso Cristiano Ribeiro Gonçalves
Published: October 2023

O presente trabalho teve como objetivo avaliar o possível efeito ansiolítico do extrato etanólico das folhas de Citrus aurantium L., sobre modelos experimentais sensíveis às drogas ansiolíticas. Os camundongos foram divididos em três grupos (teste, controle positivo, controle negativo) para administração do extrato etanólico das folhas de Citrus aurantium L., diazepam e veículo. Para avaliação da atividade motora em camundongos (atividade espontânea), foram realizados os testes de Campo Aberto “Open Field” e Esconder as Esferas. Os valores experimentais obtidos são expressos como média ± erro padrão da média (E.P.M.) e as análises estatísticas foram realizadas através da aplicação do teste Kruskal-Wallis, seguido do teste de comparação múltipla de Dunn’s e da espectrofotometria para identificação dos principais compostos presente no EECAL. Os resultados mostraram que para o grupo dos animais tratados com o EECAL (500mg/kg), observou-se uma redução significativa (p<0,05) da capacidade exploratória em 66,4±6% em relação ao controle negativo (CN), quando comparado os três tempos de forma cumulativa. Os dados da avaliação da compulsividade animal no modelo de esconder esferas, evidenciam que o EECAL (500mg/kg) reduziu significativamente (p<0,05) a compulsão aparente em 79,2±0,3%, quando comparado ao controle negativo (CN). Desta forma, tendo como base as análises realizadas, pode-se concluir que o Extrato Etanólico da Citrus aurantium L. apresenta significativo efeito ansiolítico, além da diminuição da atividade motora espontânea, indicando um possível perfil de efeito semelhante aos benzodiazepínicos com provável depressão do SNC.
Manifestações orais decorrentes de tratamento quimioterápico em crianças e adolescentes: Uma revisão integrativa
Authors: Barbosa Samara de França Viana , Freitas Juliana Felipe de , Anjos Raíssa Soares dos
Published: October 2023

Objetivo: Esta revisão integrativa teve como objetivo avaliar as principais alterações orais decorrentes da quimioterapia entre crianças e adolescentes, no tocante, ao país, desenho, duração, amostra, sexo, idade e local onde foi realizada. Materiais e métodos: O levantamento bibliográfico foi realizado através do acesso on-line da BVS Brasil (Biblioteca Virtual em Saúde) e Pubmed (Medical literature Analysis and Retrieval System on-line). Para a busca, foram usados os seguintes descritores: “Oral Manifestations”, “Drug Therapy”, “Child”, “Adolescent”. Utilizaram-se as bases de dados MEDLINE, LILACS, BBO e PUBMED nos idiomas Português, Inglês e Espanhol entre os anos de 2002 a 2022. A maioria dos estudos foram realizados no Brasil, seguido do México e Ucrânia. A amostra variou de 23 (vinte e três) a 103 (cento e três) pacientes e seu tempo de duração variou de 02 (dois) a 86 (oitenta e seis) meses. Resultados: As principais manifestações orais encontradas foram: Mucosite com prevalência de 14.2% a 98%; Infecções fúngicas 8.9% a 78%; Hipossalivação 7.4% a 100% e Úlcera 15% a 100%. Conclusão: A conclusão desta revisão integrativa mostra uma alta ocorrência de manifestações orais em pacientes infanto-juvenis submetidos a quimioterapia. Essas manifestações orais podem ser evitadas ou minimizadas através da inserção do Cirurgião-dentista como parte integrante no atendimento ao paciente, proporcionando seu bem-estar.
Pengembangan Microlearning Video dengan Menggunakan Aplikasi Canva pada Materi Sistem Peredaran Darah
Authors: Fitri Erikah Sandriah , Prayitno Trio Ageng , Hidayati Nuril
Published: October 2023

Current biology learning needs to integrate science and information technology (science and technology). Learning media is a tool that can be used by educators to integrate science and technology to make learning more interesting. However, not all educators understand this, causing problems in the learning process. The purpose of this study was to find out the form of microlearning video development using the Canva application on the circulatory system material. The method used in this study is the ADDIE development model (Analysis, Design, Development, Implementation, and Evaluation), but this study only uses three stages, namely Analysis, Design, and Development due to limited research time. The research object was class VIII at SMP PGRI 8 Malang, totaling 5 people. The research instruments used were interview transcripts, observation sheets, expert validation questionnaires, and small-scale or small-group field trial questionnaires. Research data is validation scores which will be analyzed quantitatively descriptive. The results of this research show that the development of microlearning videos using the Canva application on the circulatory system material was declared very valid in terms of aspects (91%), valid in terms of media aspects (76%), and very valid in aspects of student responses (87%). Thus, the development of microlearning videos using the Canva application on the circulatory system material is suitable for use as a learning medium in biology subjects.
Membentuk Karaktek dan Pola Pikir Kreatif melalui Bimbingan Belajar, Penyuluhan Kebersihan Lingkungan, dan Penghijauan
Authors: Ate Debora Wunga , Ate Serliati Duka , Kaka Rovinus , Astuti Endang Setiyo
Published: October 2023

Potential -Based Community Service (PMBP) is one of the three components of the Higher Education of Tri Dharma. This activity places a stronger emphasis on real activities carried out by students so that their presence in the community can be beneficial, especially to the local residents and educational institutions where the activity is located. The purpose of community service is to develop pupils' personalities in which one of the supporting elements to achieve this is the development of students' perceptions, cognition, and attitudes towards the community.The implementation of community service activities through school lessons tutoring, environmental cleanliness counseling, and go-green movement has been carried out in the village of Watu Kawula, Kota Tambolaka District, Southwest Sumba. The results of these activities include the change of local residents’ attitude toward the environmental cleanliness and the pupils’ behavior in learning pattern and supporting a better environment around them.
Pelatihan Budidaya Tanaman Sistem Hidroponik (BTSH) di SMA Maarif Lawang
Authors: Prayitno Trio Ageng , Hidayati Nuril , Mukarom Mukarom , Setiowati Firda
Published: October 2023

The lack of land at SMA Maarif Lawang affects the availability of students' practical resources in biology lessons, especially regarding plant growth and development. The agreement between the service team and SMA Maarif Lawang is that training activities must be carried out on hydroponic system plant cultivation (hspc) at SMA Maarif Lawang as a source of student practicum. The service method is carried out in 4 stages such as observation, planning, implementation, and evaluation. The implementation took place at SMA Maarif Lawang with participants from students who were in intra-school student organizations. The instruments for collecting service data use observation sheets and participant enthusiasm questionnaires. The data analysis technique was carried out using descriptive analysis. The results of the service activities showed that it was very helpful for SMA Maarif Lawang in providing practical resources for students in biology lessons and making students aware of the importance of greening in the school environment. It can be concluded that service activities run smoothly and meet achievement targets.
DİJİTAL KAMU HİZMETİ KAVRAMININ BİBLİYOGRAFİK BİR ANALİZİ
Authors: DORU Serkan
Published: October 2023

Gelişen teknoloji ile birlikte kamu hizmetlerinin dijitalleşmesi, e-Devlet ve yönetişim gibi kavramlar, ana tartışma konularını oluşturmakla birlikte bu alandaki yayınlar günümüzde de giderek artmaktadır. Bu çalışmanın amacı da siyaset bilimi ve kamu yönetimi alanında dijital kamu hizmeti içeriğine sahip, yayınlanmış makalelerin bibliyografik bir analizini gerçekleştirmektir. Bu bağlamda çalışmada siyaset bilimi ve kamu yönetimi alanında ve dijital kamu hizmeti hakkında yazılan makaleler, bibliyografik analiz kullanılarak incelenmiştir. Elde edilen verilerin analizi için VOSviewer yazılımı kullanılmıştır. Araştırmanın kapsamını ise 1992-2023 yılları arasında yayınlanan ve içeriği dijital kamu hizmeti ile ilişkili olan 765 makale oluşturmaktadır. Böylelikle dijital kamu hizmeti içeriğine yönelik yazılmış olan makaleler, en fazla atıf alan yazar, makale, dergi, üniversite, ülke kategorilerinde incelenmiştir. Ayrıca makaleler kelime analizine tabi tutulmuş, böylelikle en sık tekrar eden kavramlar tespit edilmiştir. Bu doğrultuda en sık kullanılan kavram e-Devlet olarak tespit edilmiş olup, birbirleriyle güçlü ağ ilişkileri bulunan yazarlar, makaleler, dergiler, üniversiteler ve ülkeler tespit edilmiştir.
Karyotype reexamination of Corydoras paleatus (Siluriformes) and a review of the cytogenetics of genus with a focus on the ribosomal genes
Authors: Ferreira Karla Letícia , Noleto Rafael Bueno
Published: October 2023

The subfamily Corydoradinae is the second largest among the callictids, comprising three genera, with Corydoras Lacépède, 1803 being the largest in the number of species. The genus Corydoras has been divided into five groups of species based on differences in diploid number, chromosomal morphology, and DNA content. Chromosome studies can provide crucial details on population differentiation. To better understand the diversification that occurs in this fish group, the current study based on such markers, presents data from a population of Corydoras paleatus from the first plateau of Paraná, putting them in a comparative scenario. The specimens studied has 2n=44 chromosomes with a karyotypic formula of 18m+26sm. Although conserved, this karyotypic structure shows variation in other populations of C. paleatus already studied, a consequence of chromosomal rearrangements that modify the morphology of chromosomes without modifying the 2n, such as centromeric repositioning. C-banding revealed conspicuous pericentromeric markings in metacentric pairs 4 and 8 and in submetacentric pairs 10 and 14, whose bands have been considered a chromosomal marker not only for C. paleatus but also for the genus. Fluorescent in situ hybridization (FISH) showed the major rDNA (45S) in the terminal region of the long arm of metacentric pair 5. Such location has already been described in other populations of C. paleatus, as they have also been mapped in short arms and with multiple patterns. The present study also provides a review of the genus Corydoras regarding the 2n, karyotypic formula and mainly regarding the number and location of the 45S and 5S rDNA, confirming a scenario in which chromosomal rearrangements have been modeling karyotypes of different populations and settling in the absence of gene flow, a consequence of vicariant events that occurred in the different basins.
ENVELHECIMENTO DA PESSOA COM DEFICIA
Authors: Da Silva Oliveira Iranildo , CUNHA DOS SANTOS FERNANDES ANA PAULA
Published: October 2023

Este artigo tem como objetivo analisar produções acerca do envelhecimento da pessoa com deficiência que estuda na escola regular. A pesquisa é um recorte da dissertação de Mestrado na área da Educação, na qual compreende-se que a discussão ainda é embrionária, no entanto, necessária dadas as condições de longevidade desse público. Trata-se de uma pesquisa qualitativa, sendo um estudo bibliográfico em que foram identificadas e analisadas produções de 2012 a 2016. Identificou-se que alguns apresentam discussões em outras áreas que não a educação e alguns retratam o envelhecimento associado à pessoa com deficiência intelectual, dentro disso, percebe-se que o campo está aberto para a investigação das demais deficiências.
A constituição do professor universitário do curso de Direito: uma análise de narrativas de formação
Authors: Lima Gisele Laus da Silva Pereira , Moretto Milena
Published: October 2023

O presente artigo tem como objetivo analisar de que forma o profissional, com Bacharel em Direito, assume o papel professor do Ensino Superior sem ter uma formação pedagógica durante a graduação e a pós-graduação. Para essa discussão, pautamo-nos na perspectiva histórico-cultural que discute sobre o desenvolvimento humano, a partir dos signos e das relações sociais, na perspectiva enunciativo-discursiva, que leva em consideração o caráter dialógico da linguagem e as considerações de seus envolvidos. Para tanto, apresentamos a análise de uma das entrevistas realizadas com professores bacharéis do Curso de Direito de uma instituição privada do interior de São Paulo, a partir da qual verificamos que o profissional vai se tornando professor, validando-se em exemplos de outros colegas de profissão e nas vivências – de aluno e de ensino – em sala de aula, uma vez que o trabalho de formação continuada no Ensino Superior ainda é um cenário bastante distante.
A prática docente nos Institutos Federais enunciada pelas narrativas de professores
Authors: Almeida Laura Isabel Marques Vasconcelos de , Rodrigues Sabrina de Souza , Silva Mara Rykelma da Costa , Barros Vilma Luísa Siegloch
Published: October 2023

Este artigo investiga experiências vivenciadas por professores licenciados em Matemática de Institutos Federais, objetivando compreender a carreira docente por meio de oportunidades e de obstáculos enfrentados no cotidiano profissional. Tendo a narrativa como método de pesquisa, fundamenta-se em pressupostos de autores como Clandinin e Connelly (2015) e Gonçalves (1999), ao analisar experiências profissionais valorizando as vozes de colaboradores. Os dados foram constituídos a partir de histórias presentes em cartas produzidas no desenvolvimento de uma disciplina de um curso de doutoramento. As produções apontam concepções, experiências, vivências, sensações, sentimentos e ensinamentos relativos à prática docente, retratadas de forma peculiar por cada participante. Para a análise de dados, optamos pela Análise Textual Discursiva, proposta por Moraes e Galiazzi (2011), emergindo duas categorias de discussão, cujos resultados apontam que tanto os desafios quanto as oportunidades que emergem da/na prática docente podem contribuir com a formação permanente de professores.
Experiências de jovens sobre sua participação na investigação narrativa
Authors: Oliveira Cristiane Elvira de Assis
Published: October 2023

Este texto é fruto de uma pesquisa realizada com 12 jovens de uma instituição de educação profissional e tecnológica sobre suas experiências nos tempos escolares. Nele, busco abordar os relatos desses(as) estudantes acerca de suas participações na própria pesquisa realizada de outubro a novembro de 2016. Na fundamentação teórica, utilizei Larrosa (2003), Skliar (2011) para abordar a experiência, o relato e a conversa; Connelly e Clandinin (2008) para a metodologia Investigação Narrativa. Os relatos dos(as) discentes evidenciaram que a pesquisa foi um movimento que os(as) fizeram pensar em si, lembrar de acontecimentos e dimensionar como a história de cada um(a) foi sendo tecida, permitindo-lhes fazer uma autoavaliação. Além disso, refletiram e ressignificaram a própria história, aprendendo mais sobre si no processo narrativo, destacando sua dimensão formativa. Desse modo, pude com os(as) jovens, considerar sua alteridade, legitimando-os(as) como seres capazes de refletir sobre suas práticas.
Aulas remotas na percepção de docentes universitários: relação professor e aluno no processo ensino-aprendizagem
Authors: Favretto Liani Maria Hanauer , Luca Ângela Maria Fazzioni de , Cavasin Cintia , Reis Mari Aurora Favero
Published: October 2023

Com a pandemia da Covid-19, as universidades precisaram se adaptar para dar sequência à formação acadêmica. A pesquisa oportunizou avaliar as aulas remotas, na percepção de docentes universitários, pautados em: facilidades e dificuldades, relação professor/aluno e avaliação do processo de ensino-aprendizagem. Os dados foram coletados por meio de um questionário aplicado com 51 professores em setembro de 2020. Assim os resultados apontam como facilidades: a interação por meio de novas tecnologias, home office e a possibilidade de assistir novamente às aulas. Como dificuldades foram apresentadas: a falta de atenção dos alunos e a baixa participação nas aulas. Os docentes consideraram a qualidade das aulas como “boa”, porém houve prejuízo na relação entre professor e aluno. Por fim, ao avaliar o processo de ensino-aprendizagem, constatou-se que não ocorreu da mesma forma como nas aulas presenciais, contudo as mudanças da nova modalidade, a remota, mostrou ser possível o reinventar em tempos de crise.
Cartografia da invenção: desaprender no caminhar
Authors: Cachatori Thiago Luiz , Kasper Kátia Maria
Published: October 2023

O presente estudo aborda aspectos do processo de desterritorialização de um educador-pesquisador, vivenciados entre 2017 e 2023, período em que passou a cartografar seus processos e devires. Utilizou-se, para tanto, uma metodologia pensada com Deleuze (2011) e Guattari (1990), sempre aberta ao novo. Retrata singularidades de uma pesquisa-experimentação, na qual não apenas a pesquisa foi atravessada, mas também o pesquisador, o grupo de pesquisa, seu ambiente de trabalho e suas relações sociais. É uma proposta de perambulação, assim como carrega em seu objetivo um exercício de deslocamento do centro de gravidade, um desertar, deslocar, abrir fissuras, não só como reflexões acerca da experiência do autor, mas também como provocação aos leitores. Trata-se de uma pesquisa-criação com base em uma experiência do caminhar aberto aos acontecimentos, que verifica nas inconclusões novas formas de se produzir educações menores, a partir de possibilidades inventivas que marcam os trajetos desse caminho.
Da Síria bélica à Europa da paz: o discurso neo-orientalista em (auto) biografias de refugiadas sírias
Authors: Souza Daniele dos Santos de , Zolin-Vesz Fernando
Published: October 2023

Desde 2011, tem havido um aumento na publicação de (auto)biografias de refugiadas sírias que abordam a jornada em busca de refúgio no Ocidente. Este artigo investiga o discurso neo-orientalista nas autobiografias “Nujeen” (2017), de Nujeen Mustafa e Christina Lamb, e “Borboleta: de refugiada a nadadora olímpica” (2022), de Yusra Mardini. O estudo busca compreender os efeitos de sentido dos enunciados neo-orientalistas nessas obras sobre a narrativa feminina do refúgio, que parte de uma Síria bélica em direção a uma Europa pacífica. O corpus consiste em trechos extraídos das (auto)biografias. A interpretação é fundamentada nas concepções foucaultianas de formação discursiva, enunciado, relações de poder, verdade e poder (Foucault, 2008, 2012). O referencial teórico conceitua o Orientalismo e o Neo-orientalismo, a fim de demonstrar como essas estruturas se relacionam com o corpus. Os resultados indicam que as obras analisadas contribuem para retratar o Oriente como bélico, enquanto o Ocidente é visto pacífico.
ANALISIS RESIKO MUSCULOSKELETAL DISORDER’S MATERIAL HANDLER DI PT XYZ
Authors: Sidabutar Ranto Damewilly , Zetli Sri
Published: October 2023

Ergonomics is the art, science, and application of technology used to balance the environments in which people work or rest with their physical and psychological capabilities and limitations so that the overall quality of life can be better. High demands on Material Handlers at PT XYZ are required to complete the delivery of goods on time, where in a survey conducted by Material Handler employees spend 65% of their time completing the delivery of goods. Work like this is associated with several ergonomic risks, especially the risk of musculoskeletal disorders. For precisely determining worker posture, REBA or Rapid Entire Body Assessment is a helpful technique. The highest number of respondents a total of 23 reported experiencing waist pain in the questionnaire's results for the 8 workers. with a 71.87%. Then the next largest number feels pain in the hip with a total of 22 or 68.75%. Furthermore, they felt pain in the upper right arm as much as 21 or 65.62%. It can be concluded that Material Handler activities can cause musculoskeletal disorder injuries.
IMPLEMENTASI DATA MINING MENGGUNAKAN ALGORITMA APRIORI UNTUK MENINGKATKAN POLA PENJUALAN
Authors: Adam Chairil , Handoko Koko
Published: October 2023

Medicine is a necessity for someone who is sold to people with disease. Therefore, every pharmacy or hospital must have a data processing system so that each transaction data can be used to make reports. From this report a useful result will be created to determine which drugs are most frequently purchased and sold so as to be able to determine the amount of stock at the pharmacy. But at the present time drug sales transaction data continues to increase every day so that it has accumulated because the system used is a system for storing or archiving bookkeeping without utilizing the transaction data, besides that the problem that often arises is the lack of maximum customer service at pharmacies because the drugs or needs that consumers are looking for are still not available. The a priori algorithm functions as a candidate for possible item combinations, then tests whether the combination meets the minimum support and minimum confidence parameters which are the threshold values ​​given by the user, so that it finds patterns in the form of products that will often be purchased together or products that tend to appear together in a transaction.
SISTEM PAKAR UNTUK DIAGNOSA KERUSAKAN KOMPUTER MENGGUNAKAN METODE FORWARD CHAINING DAN CERTAINTY FACTOR BERBASIS WEB
Authors: Marpaung Andy Jhonatan , Handoko Koko
Published: October 2023

Damage to the computer is caused by several problematic components such as problematic RAM, hard disk or VGA. This condition is a condition of minor damage which sometimes users consider this to be fatal damage due to a lack of knowledge about computer components, which is why an expert system is needed to help users understand. damage to the computer. In this research, the Forward chaining method will be used in the system that will be used in the program. This research will focus on a system that produces and adopts knowledge from an expert in the field and to be able to diagnose computer damage using a web-based method. An expert system is an application that uses the expertise or knowledge of an expert in a particular field and this expertise is implemented in a system.
ANALISIS KRITERIA KUALITAS VAPE BERDASARKAN PREFERENSI KONSUMEN DI KOTA BATAM
Authors: Muabdi S Ais , Asmarawati Citra Indah
Published: October 2023

This study was conducted to analyze differences in consumer preferences in determining the quality and attitudes of consumers towards vape attributes in the city of Batam. The research was conducted in Batam Kota sub-district in June 2023. The method in this study uses a survey method with interviews based on a list of questions on a questionnaire. The sample was determined by random sampling method with 168 samples. The analysis used in the research is Chi Square analysis and Fishbein Multi-attribute. Chi Square analysis shows that apart from the comparison between prices below three hundred thousand rupiahs and between three hundred thousand rupiahs to seven hundred and fifty thousand rupiahs there is a difference of 95% confidence level. This means that there are differences in consumer preferences on vape. Multi-attribute Fishbein analysis shows that there are three attributes that get good consideration and two attributes get sufficient consideration in determining the quality of vape. The order of vape attributes from the highest consideration to the lowest consideration in determining vape quality is the availability of spare parts, product design, battery life, brand and price.
ANALISIS POLA PEMBELIAN KONSUMEN MENGGUNAKAN ALGORITMA APRIORI
Authors: Putri Sartika Diana , Sitohang Sunarsan
Published: October 2023

In order for sales transaction data to be useful and useful, data development or data mining methods are needed, especially in the use of the apriori association rule algorithm, in utilizing sales transaction data obtained from items purchased simultaneously by consumers when shopping. The data is used to find out items that are often purchased by consumers to increase their stock and reduce the stocking of goods that are not selling well. The data is also used by the store in arranging the placement of goods according to consumer behavior when shopping. Data retrieval with association rule is done through a mechanism with a minimum support of 0.17 and a minimum confidence of 0.60. The purpose of this study is to determine the results of analyzing transaction data that accumulates in clothing stores into useful information and to find out what items are bought simultaneously by consumers at clothing stores to manage inventory and can make it easier to arrange the placement of goods according to consumer interests based on the value of support and confidence. From the results of this study, items that have a relationship are Women's Tops and Men's Tops with a support value of 27.86% and a confidence value of 68.00%. This information can also be used to find out what items are in great demand and less in demand by consumers in determining what stock procurement should be prioritized in the future.
RANCANG BANGUN SISTEM INFORMASI KEHADIRAN TERINTEGRASI BERBASIS WEB
Authors: Dipati Angga , Amrizal Amrizal
Published: October 2023

Attendance is an important factor for an institution, especially in the field of education, in order to achieve goals related to student discipline.There are many ways to improve the attendance information system to make it better, one of which is by using computer technology through a website-based integrated attendance system. At the MSI Imadun Ghoffar Batam school, currently they still use the manual method in the attendance system, namely by recording student attendance using a book. This method is less efficient because if the attendance book is lost or exposed to water, it will inconvenience the school and harm students. In addition, the risk of errors and loss of attendance data is also greater.Based on the problems above, we have created an attendance system at MSI Imadun Ghoffar that is integrated web-based. This system is used by parents and homeroom teachers respectively. The research method used in data collection is research and library methods. Software development uses the waterfall method. By using an integrated web-based attendance system, the attendance process, data search, and attendance recap calculations are made easier and also minimize loss and errors in recording attendance data.
DECISION TREE PADA PENILAIAN PERFORMA LAYANAN DRIVER GOJEK DENGAN ALGORITMA C4.5
Authors: Uape Frederikus Cyriaco Leu Le , Elisa Erlin
Published: October 2023

Transportation is an important means to support daily activities and operations, be it private transportation or public transportation. This study will analyze the level of customer satisfaction as a public vehicle user, in this case the author utilizes data on customers who use and utilize the gojek application as a means of transportation, using a questionnaire data collection technique, the writer will determine client satisfaction levels using the variables Tangible, Reliability, Responsiveness, Assurance, Empathy. The analytical Data mining with the is a technique employed in this investigation. concept of the Algorithm C4.5 classification which can show the results of the highest Entrophy and gain values modeled as a decision tree with the aim that the results obtained can be a guide for gojek partners to service and increase customers. Considering the outcomes of the classicization It is demonstrated by the C4.5 algorithm that the accuracy achieves 75.33% where the factors that become the assessment of satisfaction are Tangible, Reliability.
IMPLEMENTASI APLIKASI PENGENALAN SOP PENGOLAHAN LIMBAH INDUSTRI PT X BERBASIS ANDROID
Authors: Derosari Rosalinda Mentigasa , Handoko Koko
Published: October 2023

The management and proper handling of industrial waste are crucial for environmental sustainability and regulatory compliance. This project presents the development and implementation of an Android-based application designed to recognize and facilitate the adherence to Standard Operating Procedures (SOPs) in the industrial waste processing operations of PT X. The application employs advanced image recognition and processing techniques to identify and validate SOPs associated with different waste processing tasks, ensuring that employees follow the prescribed guidelines accurately. By providing real-time guidance and verification, the application aims to enhance operational efficiency, reduce errors, and promote responsible waste management practices. This paper outlines the key features, technical aspects, and benefits of the application, underscoring its potential to contribute to a more sustainable and compliant industrial waste processing environment at PT X.
ANALISIS RISIKO ERGONOMI PENJAHIT BERDASARKAN JENIS KELAMIN DI KOTA BATAM
Authors: Laia Capai , Zetli Sri
Published: October 2023

The development of the fashion sector in today's modern world is undoubtedly quite promising. Many entrepreneurs start industrial businesses in the clothing sector or what is often referred to as the garment industry, because the need for clothing production is very large. As a result of the very promising profits from the clothing business, many large, medium and small informal companies have flocked to open this business. As a profit-oriented company, on the other hand it also generates many health problems and increases the likelihood of workplace accidents. This is because there are many possible risks in the workplace, including chemical, physical, biological, ergonomic, as well as psychosocial hazards, all of which have an impact on the health of workers
ANALISIS PENGENDALIAN KUALITAS PRODUK PLASTIK DI PT. YEAKIN PLASTIC INDUSTRY
Authors: Ardianto Septian Faris , Sumantika Arsyad
Published: October 2023

In an increasingly advanced age, All kinds of work and ways change very quickly every year. oth in the field of service and manufacturing. Pt yeakin plastic industry has 3 lines one of which is plastic production, in the manufacture of its own plastic products, pt yeakin plasticindustry batam only production material that has become plastic roll into plastic polybag based on the results of observational research in the field, in finding problems in the quality of the product and in finding various defects in the product that cause the quality of plastic to be decreased and not in accordance with the standard. Procedures based on standards set by the company, the company sets its own target of a maximum of 5% of total production in the production process.the purpose of this study is to identify the level of variation in defects in the plastic production process, triggering the types of defects that occur in plastic during the cutting process at PT Yeakin Plastic Industry Batam
Phosphorylated pullulan promotes calcification during bone regeneration in the bone defects of rat tibiae
Authors: Morimoto Yasuhito , Hasegawa Tomoka , Hongo Hiromi , Yamamoto Tomomaya , Maruoka Haruhi , Haraguchi-Kitakamae Mai , Nakanishi Ko , Yamamoto Tsuneyuki , Ishizu Hotaka , Shimizu Tomohiro , Yoshihara Kumiko , Yoshida Yasuhiro , Sugaya Tsutomu , Amizuka Norio
Published: October 2023

The current study aimed to evaluate bone tissue regeneration using a combination of β-tricalcium phosphate (βTCP) and phosphorylated pullulan (PPL, a phosphate-rich polysaccharide polymer consisting of maltotriose units). Round defects of 2 mm diameter were created in the arterial center of rat tibiae, which were further treated with vehicle (control group), βTCP (βTCP group), or βTCP + PPL (βTCP + PPL group) grafts. The control specimens without bone grafts exhibited rapid bone formation after 1 week; however, the regenerated bone was not resorbed until 4 weeks. In contrast, βTCP-grafted specimens exhibited fewer but thicker trabeculae, whereas the βTCP + PPL group displayed many fine trabeculae at 4 weeks. In the βTCP + PPL group, new bone was associated with the βTCP granules and PPL. Similarly, PHOSPHO1-positive osteoblasts were localized on the βTCP granules as well as the PPL. On the other hand, TRAP-reactive osteoclasts predominantly localized on newly-formed bone and βTCP granules rather than on the PPL. No significant differences were observed in the expression of Alp, Integrin αv, Osteopontin, Osteocalcin, and Dmp-1 in PPL-treated MC3T3-E1 osteoblastic cells, suggesting that PPL did not facilitate osteoblastic differentiation. However, von Kossa staining identified abundant needle-like calcified structures extending inside the PPL. Furthermore, transmission electron microscopy (TEM) revealed many globular structures identical to calcified nodules. In addition, calcified collagen fibrils were observed in the superficial layer of the PPL. Thus, PPL may serve as a scaffold for osteoblastic bone formation and promotes calcification on its surface. In conclusion, we speculated that βTCP and PPL might promote bone regeneration and could be integrated into promising osteoconductive materials.
Analysis of different flexible technologies in the Spain NECP for 2030
Authors: Ramos Andres , Huclin Sébastien , Chaves José Pablo
Published: October 2023

This paper proposes three dimensions relevant to the flexibility assessment: power gradient (i.e., ramps), power during critical hours, and energy available at different timescales. A two-phase procedure analyzes an electric system’s flexibility to cope with renewables’ integration. The first step determines the margin on the three flexibility metrics. The second one runs a cost-based operation model to determine how these dimensions are covered. The ramp margin computed shows that a critical net demand ramp happens when solar power reduces its generation, but the projected Spanish system in 2030 can still cope with this upward ramp. Different flexible technologies cover the weekly energy variation of the net demand (demand minus non-dispatchable generation). This shows the high contribution of storage hydro and open-loop pumped-hydro storage to this variation. Flexible technologies supply upward and downward ramps of the net demand. Batteries and new closed-loop pumped-hydro storage are the storage technologies that contribute the most to these net-demand ramps. We also show that existing and new closed-loop pump-hydro storage generate more in the critical net-demand hours, having a high capacity factor, almost double the batteries.
A highly sensitive immunosensor based on nanochannel-confined nano-gold enhanced electrochemiluminescence for procalcitonin detection
Authors: Chang Qiang , Gu Xinhui , He Liming , Xi Fengna
Published: October 2023

Sensitive detection of procalcitonin (PCT) in serum is crucial for the timely diagnosis and treatment of rheumatoid arthritis. In this work, an electrochemiluminescence (ECL) detection platform is developed based on in-situ growth of Au nanoparticles (AuNPs) in nanochannels and an analyte-gated detection signal, which can realize ECL determination of PCT with high sensitivity. Vertically ordered mesoporous silica films with amine groups and uniform nanochannel array (NH2-VMSF) is easily grown on the supporting indium tin oxide (ITO) electrode through electrochemical assisted self-assembly method (EASA). Anchored by the amino groups, AuNPs were grown in-situ within the nanochannels to catalyze the generation of reactive oxygen species (ROS) and amplify the ECL signal of luminol. An immuno-recognitive interface is constructed on the outer surface of NH2-VMSF, through covalent immobilization of PCT antibodies. In the presence of PCT, the immunocomplex will hinder the diffusion of luminol and co-reactants, leading to a gating effect and decreased ECL signals. Based on this principle, the immunosensor can detect PCT in the range from 10 pg/mL to 100 ng mL-1 with a limit of detection (LOD) of 7 pg mL-1. The constructed immunosensor can also be used for detecting PCT in serum. The constructed sensor has advantages of simple fabrication and sensitive detection, demonstrating great potential in real sample analysis.
Heart fire for online live-streamed concerts: a pilot study of a smartwatch-based musician-listener interaction system
Authors: Wang Tianyi , Okada Shima
Published: October 2023

Online live-streaming has become an essential segment of the music industry in the post-COVID- era. However, methods to enhance interaction between musicians and listeners at online concerts are yet to be adequately researched. In this pilot study, we propose Heart Fire, a system to promote musician-listener interaction that visualizes the listeners' mental states using a smartwatch-based architecture. Accordingly, the listeners' heart rates are first measured using a Galaxy smartwatch and then processed into a real-time animation of a burning flame, whose intensity is dependent on the heart rate, using Azure Kinect and TouchDesigner. The feasibility of the proposed system was confirmed using an experiment involving ten subjects. Each subject selected two types of music-cheerful and relaxing. The BPM and energy of each song were measured, and each subject's heart rate was monitored. Subsequently, each subject was asked to answer a questionnaire about the emotions they experienced. The results demonstrated that the proposed system is capable of visualizing audience response to music in real time.
Characterization methods for current in-situ stress in oil and gas reservoirs: a mini review
Authors: Zhao Tianbiao , Qin Qirong
Published: October 2023

In-situ stress plays a crucial role in governing various parameters such as the distribution of oil and gas accumulation zones, the fracture pattern of reservoirs, formation fracture pressure, and collapse pressure. Understanding the distribution characteristics of current in situ stress of reservoirs has significant implications for exploration and development of oil and gas. This paper focuses on the characterization methods for current in situ stress of oil and gas reservoirs, discussing the research progress in testing methods, computational approaches, numerical simulations, and seismic prediction methods. The results indicate that the testing method including the on-site testing method and the laboratory testing method offer the relatively high accuracy, but this method only provides point-specific magnitude and direction of current in situ stress. The Computational approaches can obtain continuous profiles of current in situ stress along individual wells. After using the testing method for calibration, we can obtain relatively accurate calculation results. The numerical method can predict current in situ stress over large areas, but it requires rigorous model setup, boundary definition, and parameter selection. The seismic prediction method also can predict broad distribution of current in situ stress, but this method is influenced by many factors and we had better apply this method in conjunction with other methods. In the future, engineers and researchers should innovate testing technologies and instruments, and establish models and processes for joint use of multiple methods, and explore the development of novel current in situ stress prediction models based on artificial intelligence and big data.
High-fat diet impairs glucose homeostasis by increased p16 beta-cell expression and alters glucose homeostasis of the progeny in a parental-sex dependent manner
Authors: Escalona Rene , Larqué Carlos , Cortes Daniela , Vilchis Ricardo , Granados-Delgado Emiliano , Sánchez Abigail , Sánchez-Bringas Guadalupe , Lugo-Martínez Haydée
Published: October 2023

Introduction

Obesity consists in the accumulation of adipose tissue accompanied by low grade chronic inflammation and is considered a pandemic disease. Recent studies have observed that obesity affects females and males in a sex-dependent manner. In addition, several works have demonstrated that parental obesity increases the risk to develop obesity, insulin resistance, diabetes, and reproductive disorders. Considering that intergenerational effects of obesity may occur in a sex-dependent manner, we studied male Wistar rat progeny (F1) obtained from mothers or fathers (F0) fed on a high-fat diet (HFD).

Methods

Five-week-old female and male Wistar rats were fed on a HFD (with 60% of calories provided by fat) for 18 weeks (F0). At the end of the treatment, animals were mated with young rats to obtain their progeny (F1). After weaning, F1 animals were fed on standard chow until 18 weeks of age. Body weight gain, fasting plasma glucose, insulin and leptin levels, glucose tolerance, insulin sensitivity, and adiposity were evaluated. In addition, beta-cell expression of nuclear p16 was assessed by immunofluorescence.

Results and conclusions

HFD altered plasma fasting glucose, insulin and leptin levels, glucose tolerance, adiposity, and beta-cell expression of p16 in F0 rats. Particularly, HFD showed sexual dimorphic effects on body weight gain and insulin sensitivity. Moreover, we observed that parental HFD feeding exerts parental-sex-specific metabolic impairment in the male progeny. Finally, parental metabolic dysfunction could be in part attributed to the increased beta-cell expression of p16; other mechanisms could be involved in the offspring glucose homeostasis.
Environmental regulation, green credit, and farmers’ adoption of agricultural green production technology based on the perspective of tripartite evolutionary game
Authors: Zuo Zhi Ping
Published: October 2023

The adoption of agricultural green production technologies (AGPTs) is crucial for achieving agricultural green development in developing countries. This paper establishes a tripartite game model to explore the evolutionary influence mechanism of government environmental regulation policies and bank green credit policies on farmers’ adoption of AGPT under different initial conditions and strategy choices. Through theoretical analysis and numerical simulation, we systematically deduce the evolutionary path and equilibrium conditions, as well as examine the synergistic evolutionary effect of these policies. The results demonstrate that government environmental regulation and banks’ implementation of the green credit policies effectively encourage farmers to adopt AGPT. However, conflicts may arise during the dynamic evolution process when banks choose to implement the green credit policy. These conflicts can be mitigated by utilizing market-oriented mechanisms such as loan interest rates, improving bank supervision efficiency, and enhancing farmers’ expected income. The findings of this research provide valuable insights into the development of external incentive mechanisms to promote the adoption of AGPT among farmers and foster green agricultural development.
Identification of the shared gene signature and biological mechanism between type 2 diabetes and colorectal cancer
Authors: Liu Xianqiang , Li Dingchang , Gao Wenxing , Zhao Wen , Jin Lujia , Chen Peng , Liu Hao , Zhao Yingjie , Dong Guanglong
Published: October 2023

Background: The correlation of type 2 diabetes mellitus (T2DM) with colorectal cancer (CRC) has garnered considerable attention in the scientific community. Despite this, the molecular mechanisms underlying the interaction between these two diseases are yet to be elucidated. Hence, the present investigation aims to explore the shared gene signatures, immune profiles, and drug sensitivity patterns that exist between CRC and T2DM.

Methods: RNA sequences and characteristics of patients with CRC and T2DM were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus databases. These were investigated using weighted gene co-expression network analysis (WGCNA) to determine the co-expression networks linked to the conditions. Genes shared between CRC and T2DM were analyzed by univariate regression, followed by risk prognosis assessment using the LASSO regression model. Various parameters were assessed through different software such as the ESTIMATE, CIBERSORT, AND SSGSEA utilized for tumor immune infiltration assessment in the high- and low-risk groups. Additionally, pRRophetic was utilized to assess the sensitivity to chemotherapeutic agents in both groups. This was followed by diagnostic modeling using logistic modeling and clinical prediction modeling using the nomogram.

Results: WGCNA recognized four and five modules that displayed a high correlation with T2DM and CRC, respectively. In total, 868 genes were shared between CRC and T2DM, with 14 key shared genes being identified in the follow-up analysis. The overall survival (OS) of patients in the low-risk group was better than that of patients in the high-risk group. In contrast, the high-risk group exhibited higher expression levels of immune checkpoints The Cox regression analyses established that the risk-score model possessed independent prognostic value in predicting OS. To facilitate the prediction of OS and cause-specific survival, the nomogram was established utilizing the Cox regression model.

Conclusion: The T2DM + CRC risk-score model enabled independent prediction of OS in individuals with CRC. Moreover, these findings revealed novel genes that hold promise as therapeutic targets or biomarkers in clinical settings.
Transcription factors direct epigenetic reprogramming at specific loci in human cancers
Authors: Jiang Han , Li Guoxin
Published: October 2023

The characterization of epigenetic changes during cancer development and progression led to notable insights regarding the roles of cancer-specific epigenetic reprogramming. Recent studies showed that transcription factors (TFs) are capable to regulate epigenetic reprogramming at specific loci in different cancer types through their DNA-binding activities. However, the causal association of dynamic histone modification change mediated by TFs is still not well elucidated. Here we evaluated the impacts of 636 transcription factor binding activities on histone modification in 24 cancer types. We performed Instrumental Variables analysis by using genetic lesions of TFs as our instrumental proxies, which previously discovered to be associated with histone mark activities. As a result, we showed a total of 6 EpiTFs as strong directors of epigenetic reprogramming of histone modification in cancers, which alters the molecular and clinical phenotypes of cancer. Together our findings highlight a causal mechanism driven by the TFs and genome-wide histone modification, which is relevant to multiple status of oncogenesis.