bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on depth control of machining trace in electrochemical trepanning
Authors: Li Zhengyin , Zhu Dong , Zhang Xiaobo , Lin Jiahao
Published: August 2023

Electrochemical trepanning (ECTr) is a highly effective and economic manufacturing technology for machining difficult-to-cut metal materials that are often used in aeroengine components. Integral structural components such as blisks, diffusers, etc. are composed of hubs and blades. In continuous ECTr, machining trace stems from on the hub between adjacent blades. The depth of machining trace significantly influences the surface integrity of the integrated components, even causes the scrapping of the workpiece. In order to solve the problem of machining trace in ECTr, a cathode design method based on the relation between cathode profile and electric field distribution is proposed in this study, the edge of the cathode that affects the machining trace is chamfered. A electric field model of ECTr is established and dynamic electric field simulation of ECTr for cathodes with different chamfered edges is performed. The electric field intensity distribution at the cathode edge and the forming profile of the hub are compared. The simulation results show that optimal chamfering parameters can improve the machining trace. Subsequently, a group of cathodes with different chamfered edge is designed, and corresponding ECTr experiments are conducted. The optimal chamfering parameters are determined (α = 5°, b = 2 mm), the depth of the machining trace is reduced from 0.370 mm to 0.122 mm, the surface flatness is significantly improved. Overall, this depth control method of machining trace is verified effectively.
Al2O3 Nano filler’s impact on electrical, mechanical, thermal, microstructural and the chemical characteristics of liquid silicone rubber for composite insulators
Authors: Adupa Shirisha , Pulla Sammaiah , Alavala Chennakesava Reddy
Published: August 2023

This study examines the function of Al2O3 nanofiller in liquid silicone rubber (LSR) for the purpose of outdoor insulation. Several characteristics, including structural (Field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), physical (density), mechanical (tensile, tear, percentage elongation at break, and shore A hardness), thermal (thermal conductivity, thermo gravimetric analysis (TGA)), electrical (dielectric constant, dielectric breakdown strength, DC volume resistivity, arc resistance, and recovery of hydrophobicity), although chemical (immersion of samples for 72 h in NaCl, HCl, and H2SO4 solutions and measurement of sample weight and PH of the solution before and after immersion) were investigated after the addition of Al2O3 nanofiller with different compositions, such as 5, 10, and 15 weight percentages. In comparison to pure LSR, it was discovered that the inclusion of nano Al2O3 particles enhanced the material’s density by 11%, thermal conductivity by 12%, dielectric constant by 24%, DC volume resistivity by 2%, arc resistance by significantly 1205%, dielectric breakdown strength by 54%, and hydrophobicity. Other improvements include a 7% rise in tensile strength, a 23% rise in tear strength, a 17% rise in hardness, and an 18% reduction in percentage elongation at break when compared to pure LSR for the composite samples. Mechanical qualities are affected by the curing process duration. More specifically, we discovered there is a proportionality relationship between the tensile strength and the elastic modulus. Findings of the chemical examination revealed that the composites have corrosion resistance in the form of negligible weight change in the sample when exposed to salt and acid solutions. The combination of these exceptional qualities makes Al2O3 composites appealing within an insulating materials realm.
Slip ratio adaptive control for distributed drive electric vehicle based on wheel speed
Authors: Chen Qiping , Huang Liang , Gan Lu , Kang Sheng , Wan Rui
Published: August 2023

Aiming at the problems of poor control effect and poor robustness for distributed drive electric vehicles driving on complex and changeable roads, this paper proposes a slip ratio adaptive control method based on wheel speed. Firstly, an optimal slip ratio estimator considering axle load transfer was developed by analyzing the single-wheel dynamics of the vehicle and based on the Burckhardt tire model. Secondly, a cubic polynomial function is used to fit and optimize the optimal slip ratio-peak adhesion coefficient curve, which effectively improves the accuracy of obtaining the optimal slip ratio. Then, a conditional integral sliding mode controller based on wheel speed is designed in order to enhance the transient characteristics of the sliding mode control, to avoid integral saturation, and to improve the control effect of the sliding ratio controller in the low speed start-up phase. Finally, three typical working conditions, namely single road, flat road, and slip road, were established for simulation and experimental validation. The results show that the method in this paper is able to estimate the optimal slip ratio of the road in real time, realize the wheel slip ratio adaptive control, and improve the dynamic performance and lateral stability of distributed drive electric vehicle.
From criticism to conspiracies: The populist discourse of COVID-19 sceptics in Germany’s Querdenken community on Telegram
Authors: Almodt Rémi
Published: August 2023

Telegram is a central space for unifying far-right actors and ideology, activists and movements, alternative media, conspiracies, and Coronavirus scepticism. While much research has focused on network dynamics and topic modelling, there is a scarcity of large scale, in-depth content analyses. The present research examines this environment through a semi-automated content analysis of German COVID-19 protest movement Querdenken on Telegram, to determine discursive features of the politicisation of this public health crisis within Querdenken’s communities. The analysis of 1.4 million chat messages shows that key elements of right-wing populist discourse can be detected in several sub-communities. The people and the homeland are antagonised by the corrupt, oppressive elite. Within this environment, politicised anti-COVID-19 restrictions narratives combine with populist discourse, distributed from Querdenken channels via general information channels, connecting to activist, protest, news, lawyer, and doctor-themed chats. Within these channels, external links lead towards publications promoting far-right ideology and conspiracies.
Wealth Effects of Share Repurchase Decision of IPO Firms: Evidence from India
Authors: Khan Aafreen , Khanna Ashu
Published: August 2023

The present study shades light on the short-term wealth effects of the share repurchase decision of Indian IPO firms on their stock prices. For the years 2000–2019, the sample considers the IPO companies who announce buybacks within 5 years after their listing. By evaluating short-term fluctuations in stock prices around the buyback announcement date, wealth effects have been quantified using the event study approach. According to our empirical investigation, investors responded favourably to the news and produced positive 1.13% nonsignificant abnormal returns on the event day. Further investigation finds that these companies likewise endure erratic stock performance in the days that follow the announcement, with the exception of the day when they actually purchase back their shares, which produced positive and significant abnormal returns to investors of 0.92%. Also, over the event window, the results are positive at 10.69% and significant. Our results show that investors favourably view share repurchase by IPO firms and can regard it as a sound investment strategy. This study also adds to the scanty literature about newly listed firms’ payout preferences.
Expressed Emotion in Families of Children with Neurodevelopmental Disorders: A Mixed-Method Approach
Authors: Balachandran Krishna Priya , Bhuvaneswari Mohanraj
Published: August 2023

Background

Family interaction plays a pivotal role in the overall well-being of each member of a family unit. It is foreseeable that a family caring for an individual with a mental or physical health condition could experience negative family interactions for various reasons. Expressed emotion refers to the family environment based on the relatives’ interaction with the individual diagnosed with a specific illness. Expressed emotion in the families of a person with any form of mental condition could pose potential psychological distress and burden to family members, notably the primary caregivers.

Purpose

The current study intends to explore the expressed emotion of the primary caregivers toward children with neurodevelopmental disorders (NDDs). The association between expressed emotion, stress experienced by the caregiver, and the self-sufficiency of the child diagnosed with neurodevelopmental disorders was examined.

Methods

The Five-Minute Speech Sample (FMSS), Kingston Caregivers’ Stress Scale (KCSS), and Waisman Activities of Daily Living (WADL) were used to assess expressed emotion, stress, and a child’s self-sufficiency, respectively. The snowball sampling technique was adopted, and data were collected from 35 primary caregivers through telephonic interviews. A mixed-method research design was adopted, and the data were analyzed qualitatively and quantitatively.

Results

The findings reveal that there is a significant association between expressed emotion and caregivers’ stress, expressed emotion, and the child’s self-sufficiency and a significant relationship between the caregivers’ stress and the child’s self-sufficiency. The qualitative analysis suggests the influence of factors such as future concerns, family factors, and relationship strains contribute to expressed emotion.

Conclusion

It can be concluded that those primary caregivers who reported extreme caregivers’ stress and low self-sufficiency in their child exhibited high negative expressed emotion and diverse individual and systemic factors influenced the display of high expressed emotion within the family.
Reconsidering Miranda rights: Modeling strategic action during the invocation stage of a police interrogation
Authors: Mason Robert D , Mason Marianne
Published: August 2023

This paper develops a method to identify manipulation of custodial suspects who attempt to invoke the Miranda right to legal counsel during a custodial interrogation. The method, developed from a combination of framing theory and hypergame theory, first documents the point where custodial suspects’ preferences shift and second identifies the proximate cause of that shift using excerpts from legal cases. The method applies linguistic analysis within a hypergame framework to reveal rational behavior of custodial suspects who, despite owning an initial preference to invoke, waive their right to counsel without explicit pressure from police. The paper terms this shift in preferences “manipulation” adding the concept to hypergames and to the literature on noncooperative discursive exchanges.
“There’s an Etiquette to Zoom That’s Not Really Present In-Person”: A Qualitative Study Showing How the Mute Button Shapes Virtual Postpartum Support for New Parents
Authors: MacLeod Anna , Aston Megan , Price Sheri , Stone Kathryn , Ollivier Rachel , Benoit Britney , Sim Meaghan , Marcellus Lenora , Jack Susan , Joy Phillip , Gholampourch Masoumeh , Iduye Damilola
Published: August 2023

Virtual spaces that allow parents in the postpartum period to connect, support each other, and exchange information have been increasing in popularity. With the COVID-19 pandemic, many parents had to rely on virtual platforms as a primary means to connect with others and attend to their postpartum health. This study explored virtual postpartum support sessions through the web-based videoconferencing software, Zoom. Guided by feminist poststructuralism and sociomaterialism, we held seven virtual support sessions for parents caring for a baby 0–12 months in age, in Canada, and interviewed 19 participants about their experiences in the sessions. Our methodological approach allowed us to analyze discourses of (1) parenthood, (2) material realities of virtual environments, and (3) support and information on this virtual platform. The purpose of this research was to understand how technology influences postpartum support and learning through online videoconferencing for parents. Our findings document an overarching discourse of Zoom etiquette by which muting was a discursive practice that all participants used. The consistent use of the mute button while not talking structured conversation in virtual postpartum sessions and resulted in three themes: (1) minimizing disruptions; (2) taking turns; and (3) staying on task. The norm of using the mute button changed how parents received and gave support and information. Based on findings and broader literature, we discuss considerations for facilitation of virtual postpartum support sessions.
Can Velopharyngeal MRI be Used in Individuals with Orthodontic Devices?
Authors: Perry Jamie L. , Schleif Eshan , Fang Xiang Ming , Briley Patrick M. , McCarlie Jr V. Wallace
Published: August 2023

Objective

To evaluate the influence of common pediatric orthodontic appliances on velopharyngeal (VP) MRI and to compare MR image sequences to determine if sequence parameters impact the visibility of key VP structures commonly assessed in clinical VP MRI.

Design

Participants undergoing orthodontic treatment completed a VP MRI study. Level of distortion caused by orthodontic devices on 8 anatomical sites of interest and using variable MRI sequences was evaluated.

Setting

Single institution

Participants

Nineteen participants undergoing orthodontic treatment.

Main Outcome

Level of distortion caused by metal artifacts and MR sequence used.

Results

The results of this study demonstrate that appliances such as hyrax palatal expanders and braces with stainless steel brackets are acceptable for a VP MRI, while class II corrector springs are not recommended. The HASTE MRI sequence with 2D imaging techniques should be utilized if the child has orthodontic devices, while FSE and 3D imaging techniques are not recommended. The presence of wire spring coils and molar bands are likely to not to interfere with the MRI evaluation.

Conclusions

Findings from this study suggest that the presence of orthodontic appliances does not hinder visualization of all velopharyngeal structures during an MRI. Therefore, careful consideration must be made prior to disqualifying or recommending patients for VP MRI.
Application of biodegradable colorimetric films based on purple tomatoes anthocyanins loaded chitosan and polyvinyl alcohol in pork meat
Authors: Yana Li , Zhiwei Chen , Yunuo Zhang , Jingxi Wu
Published: August 2023

A series of biodegradable colorimetric films were prepared by using chitosan and polyvinyl alcohol as matrix, in which, the weight ratio of chitosan: Polyvinyl alcohol was 100: 0, 80: 20, 50: 50, 20: 80, or 0: 100, with addition of 10% (w/w, relative to chitosan) anthocyanins extracted from purple tomatoes (purple tomatoes anthocyanin) as pigment. The aim of this study was to observe the effect of weight ratio (chitosan: Polyvinyl alcohol) on the mechanical properties, contact angle, swelling rate, pH sensitivity, antioxidant properties of chitosan-polyvinyl alcohol/purple tomatoes anthocyanins films, and the antibacterial activity of films produced for pork packaging. In addition, the films as a smart colorimetric indicator for monitoring the freshness of pork was investigated. The results showed that as the ratio of chitosan to polyvinyl alcohol decreases, the elongation at break, hydrophilicity, and swelling rate of the films increased especially from 16.5% to 174.2% for elongation at break and 93.0° to 53.8° for water contact angle, however, the tensile strength decreased from 67.3 to 24.7 MPa. With decreasing of chitosan: Polyvinyl alcohol, the antibacterial activity on pork was decreased, and the antioxidant properties of films increased first then decreased. Fourier transform infrared spectroscopy indicated there were interactions among chitosan, polyvinyl alcohol, and purple tomatoes anthocyanins. The color response of films was depended on pH, as well as the immersion time. The longer immersion resulted in a more pronounced color change. The color changed from purplish red (pH 2–4) to green (pH 5–10) to yellow (pH 10–12). In monitoring the freshness of pork, the film showed a nice visual color change, indicating a potential application in smart packaging. These bio-based materials may be useful alternatives to synthetic plastics for food applications such as active and smart packaging, thereby improving the environmental friendliness and sustainability of the food supply.
Ultrasonication and thermosonication applied in the processing of jalapeno pepper (Capsicum annuum var. annuum) sauce
Authors: Artilha-Mesquita Carla A F , Stafussa Ana P , Rodrigues Letícia M , Silva Evandro , Pilau Eduardo J , Madrona Grasiele S
Published: August 2023

Ultrasonication is one of the non-thermal physical methods that can be used on foods and when used in synergy with temperature (thermosonication), this technique proves to be more effective, thus reducing the duration and intensity of heat treatment and the consequent damage to the foods. This work aimed to use the technique of ultrasonication and thermosonication in the processing of jalapeno pepper sauces in comparison with pasteurization. Two types of sauces were produced, one with pre-cooking (a) and the other without cooking (b), and the influence of time and temperature was analyzed by applying ultrasonication and thermosonication. Times of 15 and 30 min and temperatures of 25 and 65 °C were used. Both treatments stood out for their effectiveness when compared to the traditional method (pasteurization 65 °C and 30 min). The results demonstrate that, in general, the sauces are good sources of phenolic compounds (141.83 ± 0.10 mg gallic acid equivalent/100 g), flavonoids (50.40 ± 0.30 mg quercetin equivalent/100 g) and carotenoids (2.39 ± 0.07 mg β-carotene/100 g). The sauces had an increase in carotenoids by about 25% (thermosonicated at 15 and 30 min and pre-cooked) and in antioxidant activity (ferric reducing antioxidant power) with about 12% and 13% (thermosonicated at 30 min with and without cooking, respectively) in relation to control (pasteurization). On comparing thermosonication with ultrasound process total phenolics had improved by around 14% and flavonoids by 55%. At the first time, capsantin, capsaicin, dihydrocapsaicin, and nordihydrocapsaicin were identified by ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS). Finally, as both treatments demonstrate efficiency (thermosonication at 15 and 30 min), the use of 15 min is indicated as feasible by the reduced process time and in preventing the loss of bioactive compounds in the sauces when compared to the pasteurization treatment.
Assessing the Safety of MA-[D-Leu-4]-OB3, a Synthetic Peptide Leptin Mimetic: Two Pre-Clinical Toxicity Studies in Male and Female C57BL/6 Mice
Authors: Enemark Forrest , Novakovic Zachary M. , Grasso Patricia
Published: August 2023

Although the regulatory influence of leptin on energy balance, glycemic control, immunity, reproduction, and cognition is well established, its clinical application to common obesity and its co-morbidities has been limited by impaired transport across the blood-brain barrier, and tendencies to induce adverse side effects. To circumvent these drawbacks, MA-[D-Leu-4]-OB3, a leptin-related synthetic peptide that mimics the metabolic and neurotrophic effects of leptin in mouse models of genetic and non-genetic obesity, diabetes, and cognitive dysfunction, has been developed. This report presents the results of our initial efforts to assess the safety of orally delivered MA-[D-Leu-4]-OB3. Two pre-clinical studies were done in male and female C57BL/6 mice: a short-term study with a high dose of MA-[D-Leu-4]-OB3 (50 mg/kg/100 μL/day) and a dose-response study with 3 increasing concentrations of MA-[D-Leu-4]-OB3 (16.6, 50, and 150 mg/kg/100 μL/day). Body weight, food and water intake, glucose tolerance, and episodic memory were evaluated. Once-daily cage-side clinical observations were conducted to detect any physical or behavioral indicators of toxicity. Our results indicate that all metabolic and neurologic endpoints tested were either unaffected or improved by MA-[D-Leu-4]-OB3, and no clinical indicators of toxicity were evident. Together with our previously reported efficacy data, these results provide additional evidence supporting further development of this novel synthetic peptide leptin mimetic as a first-in-class peptide drug candidate for the treatment of a number of metabolic and/or cognitive dysfunctions in humans.
Assessing heterogeneity of treatment effect in multiple sclerosis trials
Authors: Sormani Maria Pia , Chataway Jeremy , Kent David M , Marrie Ruth Ann
Published: August 2023

Multiple sclerosis (MS) is heterogeneous with respect to outcomes, and evaluating possible heterogeneity of treatment effect (HTE) is of high interest. HTE is non-random variation in the magnitude of a treatment effect on a clinical outcome across levels of a covariate (i.e. a patient attribute or set of attributes). Multiple statistical techniques can evaluate HTE. The simplest but most bias-prone is conventional one variable-at-a-time subgroup analysis. Recently, multivariable predictive approaches have been promoted to provide more patient-centered results, by accounting for multiple relevant attributes simultaneously. We review approaches used to estimate HTE in clinical trials of MS.
Assessment of bleeding risk in low-weight patients receiving prophylactic subcutaneous unfractionated heparin
Authors: Jatis Andrew J , Nei Scott D , Zieminski Joseph J , Mara Kristin , Krauter Abby K
Published: August 2023

Background:

Underweight patients may be at an increased risk of bleeding while receiving venous thromboembolism (VTE) prophylaxis. Additional evidence is needed to identify patient-specific factors associated with bleeding. The objective of the study was to describe the incidence and identify risk factors associated with bleeding in low-weight (⩽ 60 kg) adult patients receiving subcutaneous unfractionated heparin (SQH) for VTE prophylaxis.

Methods:

This was a single-center, retrospective, nested case–control study of low-weight patients receiving SQH for VTE prophylaxis for ⩾ 48 hours. Cases, patients with clinically relevant bleeding while receiving SQH, and controls, patients without a bleeding event, were matched in a 1:3 ratio for age, sex, primary service (surgical or medical), and time at risk of bleeding on SQH to determine factors associated with bleeding.

Results:

A total of 3761 patients met the inclusion criteria, of which 38 cases of clinically relevant bleeding were identified. The bleeding incidence was 1% at hospital day 6 and 2.8% at hospital day 14. Most patients in this study (69%) received SQH 5000 units three times daily. ICU admission at SQH start was associated with bleeding, OR 2.97 (95% CI 1.21–7.29).

Conclusion:

Bleeding in low-weight patients on prophylactic SQH was uncommon. Patients admitted to the ICU at time of SQH start may be at a higher risk of bleeding. Further studies are needed to detect additional risk factors associated with bleeding and investigate the effects of reduced dosing in this population.
Chinese international students’ wellbeing: Experiences of assessment in higher education
Authors: Dai Qiao
Published: August 2023

While there is growing research identifying the academic and nonacademic challenges to the wellbeing of Chinese international students, there is little discussion about the differences in and challenges of the assessment they experience. This gap appears to come from a tacit assumption that assessment is universal worldwide, or that students will automatically learn strategies to deal with all the contrasts in assessment themselves. Based on personal experience, literature review and the interview responses of a group of Chinese international students’ in the UK answers are sought to three research questions regarding their experiences. Academic hospitality is the theoretical underpinning of the research as this emphasises the bilateral collaboration between international students and higher education providers to support students’ successful transition. The findings show that most participants were surprised and confused about the variety of assessment formats, the expected answers for assessment, and the autonomous learning they experienced in the UK, which were diverse from previous experience in China. While most Chinese students used similar strategies when they first encountered assessment in British universities, they developed new strategies when they realised the diverse expectations. These Chinese internationals needed ongoing support for assessment from the whole university.
A Randomized Controlled Trial of Community Health Specialists Within Gender-Responsive Probation Supervision
Authors: Salisbury Emily J. , Belisle Linsey A. , Mercier Mariah Cowell , Prince Kort
Published: August 2023

A randomized controlled trial was conducted to assess the experiences of women probationers engaged in gender-responsive supervision with community health supports versus ‘gender-responsive supervision as usual.’ Treatment group participants engaged in a new supervision model in a large metropolitan county in a Western state which was created to improve their specific responsivity needs and public health supports. The Women’s Reentry Assessment, Programming, and Services (WRAPS) model included enhanced wraparound, gender-responsive, and trauma-informed supervision that incorporated Community Health Specialists (CHSs) working alongside probation officers. Although the WRAPS intervention did not reduce recidivism relative to the control group, there is evidence that gender-responsive probation supervision does reduce recidivism overall when compared to baseline. Findings from interview data indicate strong support for gender-responsive probation in general and the WRAPS model in particular. Clients and staff viewed the CHS role as highly impactful in addressing women’s specific responsivity needs and supporting women’s success. Recommendations surrounding gender-responsive probation and integration of public health staff are discussed.
Polarization and the Psychology of Collectives
Authors: Levin Simon A. , Weber Elke U.
Published: August 2023

Achieving global sustainability in the face of climate change, pandemics, and other global systemic threats will require collective intelligence and collective action beyond what we are currently experiencing. Increasing polarization within nations and populist trends that undercut international cooperation make the problem even harder. Allegiance within groups is often strengthened because of conflict among groups, leading to a form of polarization termed “affective.” Hope for addressing these global problems will require recognition of the commonality in threats facing all groups collective intelligence that integrates relevant inputs from all sources but fights misinformation and coordinated, cooperative collective action. Elinor Ostrom’s notion of polycentric governance, involving centers of decision-making from the local to the global in a complex interacting framework, may provide a possible pathway to achieve these goals.
Why We Mimic Emotions Even When No One is Watching: Limited Visual Contact and Emotional Mimicry
Authors: Olszanowski Michal , Wróbel Monika
Published: August 2023

This article explores interpersonal functions of emotional mimicry under the absence versus the presence of visual contact between the interacting partners. We review relevant literature and stress that previous studies on the role of emotional mimicry were focused on imitative responses to facial displays. We also show that the rules explaining why people mimic facial expressions may be inapplicable when visual signals are unavailable (e.g., people attending an online meeting have their cameras off). Overall, our review suggests that emotional mimicry functionally adapts to whether the perceiver and the expresser can see each other. We, therefore, argue that blocking visual contact between them may provide insight into emotional mimicry's social functions, thereby clarifying its role in fostering affiliation and emotional understanding.
Sustainable Energy Siting, Affect, and Climate Mitigation: Questions for a Future Research Agenda
Authors: Russell Aaron , Firestone Jeremy
Published: August 2023

The affective sciences are essential to research regarding sustainable transition towards renewable energy. We focus on important questions that should be addressed by affective science in relation to the siting of large-scale renewable energy projects like wind and solar. Considering the recent acceleration of the transition, a more holistic understanding of negative and positive emotional responses to energy development will be essential. This is particularly important as the least controversial sites begin to dwindle in number. We break this commentary down into four primary question categories for future research. These are the causal relationships between emotional elicitations and their sources, dual processing through cognitive and affective response, affect and its relationship with place, and how all of these elements change over time.
Tackling health and social inequalities in primary care
Authors: Mishra Dr Vinayak
Published: August 2023

Social inequalities produce disparities in access to communal benefits such as health, education, and jobs, arising, for example, not only from social parameters like ethnicity and gender, but also from government policies and societal practices. The complex interplay between an individual's social environment, including housing and income, significantly influences their health. This article focuses on how primary care services can tackle health and social inequalities. It discusses the ramifications of the Inverse Care Law, how it is still applicable after more than half a century, and how Deep End general practices and social prescribing measures attempt to curb social and health inequalities.
mTOR pathway – a potential therapeutic target in stroke
Authors: Melanis Konstantinos , Stefanou Maria-Ioanna , Themistoklis Konstantinos M. , Papasilekas Themistoklis
Published: August 2023

Stroke is ranked as the second leading cause of death worldwide and a major cause of long-term disability. A potential therapeutic target that could offer favorable outcomes in stroke is the mammalian target of rapamycin (mTOR) pathway. mTOR is a serine/threonine kinase that composes two protein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), and is regulated by other proteins such as the tuberous sclerosis complex. Through a significant number of signaling pathways, the mTOR pathway can modulate the processes of post-ischemic inflammation and autophagy, both of which play an integral part in the pathophysiological cascade of stroke. Promoting or inhibiting such processes under ischemic conditions can lead to apoptosis or instead sustained viability of neurons. The purpose of this review is to examine the pathophysiological role of mTOR in acute ischemic stroke, while highlighting promising neuroprotective agents such as hamartin for therapeutic modulation of this pathway. The therapeutic potential of mTOR is also discussed, with emphasis on implicated molecules and pathway steps that warrant further elucidation in order for their neuroprotective properties to be efficiently tested in future clinical trials.
An evidence-informed rehabilitation management framework for posterior shoulder tightness: A scoping review
Authors: Fukushima Yukino , Avilineni Murali , Kao Michelle , Tirmizey Haider , Faber Kenneth J. , Furtado Rochelle , Sadi Jackie
Published: August 2023

Objective

To systematically scope the literature on posterior shoulder tightness (PST) and define a therapist-instructed and therapist-administered management framework.

Design

Scoping review.

Literature search

We searched MEDLINE, EMBASE, CINAHL, Scopus and Google Scholar from inception to December 2021.

Study selection criteria

Peer-reviewed studies written in English, French, Greek, Japanese or Tamil, with extractable pre- and post-intervention data. Physiotherapy interventions amenable for posterior shoulder structural (muscle, capsule) causes of PST within an adult population.

Data synthesis

Arksey and O’Malley's framework was implemented and the PRISMA extension for scoping reviews directed our data synthesis. The data charted from each study included authors, title, study year, location, study design; participant number, age, sex; PST intervention and parameters; patient-reported outcomes; and results. Themes were organized into therapist-instructed and therapist-administered rehabilitation strategies, as well as combined treatment methods.

Results

Of 2777 articles identified from our search strategy, 21 articles were included. Therapist-instructed interventions included cross-body stretch (CBS), sleeper stretch (SS), a combination of the two and general stretching. Therapist-administered interventions included CBS, SS, instrument-assisted soft tissue mobilization (IASTM), muscle energy techniques, dry needling and Fauls protocol (12 therapist-assisted stretches). Combined interventions of tape with self-stretching and IASTM and stretching were also identified.

Conclusion

Based on the current evidence, CBS and SS are the most researched treatments for PST and seem to be effective at improving PST. Furthermore, stabilization of the scapula while performing these stretches optimized the stretch targeted to the PST and ROM benefits for horizontal adduction.
Caffeic Acid Inhibits Proliferation, Migration, and Stemness of DU-145 Prostate Cancer Cells
Authors: Aikins Anastasia Rosebud , Birikorang Peggy Afua , Sabah Selorm Bless , Baffoe Samuel Mensah , Tetteh John Kweku Amissah , Quarshie Jude Tetteh , Quaye Osbourne
Published: August 2023

The issue of toxicity associated with existing cancer drugs necessitates the exploration of the anticancer potentials of natural products such as caffeic acid (CA). Here, we determined the effect of CA on the proliferation, migration, and stem cell-like properties of DU-145 prostate cancer cells. Tetrazolium-based colorimetric assay and flow cytometric analysis showed that CA decreased cell proliferation in a dose- and time-dependent manner without affecting cell cycle progression. CA also inhibited cell migration and repressed epithelial-to-mesenchymal transition by upregulating the expression of cadherin 1 (CDH1) and downregulating the expression of cadherin 2 (CDH2). Furthermore, CA reduced the cancer stem cell population from 95% to 63% and 47% at concentrations of 1.25 and 2.5 mg/mL, respectively; and inhibited stem cell-like properties by downregulating the expression of NANOG and octamer-binding transcription factor 4 (OCT4) genes. These findings suggest that CA could be considered in the development of improved chemotherapy against prostate cancer.
Can Symmetry of Single-Leg Vertical Jump Height Represent Normal Lower Limb Biomechanics of Athletes After Anterior Cruciate Ligament Reconstruction?
Authors: Chen Peng , Wang Ling , Dong Shiyu , Ding Yue , Jia Shaohui , Zheng Cheng
Published: August 2023

Background:

After anterior cruciate ligament reconstruction (ACLR), single-leg horizontal hop distance limb symmetry index (LSI) >90% is recommended as a cutoff point for safe return to sport (RTS). However, athletes after ACLR have abnormal lower limb biomechanics despite an adequate single-leg hop distance LSI, implying that athletes are at high risk of reinjury. Symmetry of single-leg vertical jump height appears to be more difficult to achieve and can be a better representation of knee function than single-leg horizontal hop distance.

Hypothesis:

Athletes after ACLR with single-leg jump height LSI >90% had similar biomechanical characteristics to healthy athletes.

Study Design:

Controlled laboratory study.

Level of Evidence:

Level 3.

Methods:

A total of 46 athletes after ACLR were divided into low jump height (LJH, jump height LSI <90%, n = 23) and high jump height (HJH, jump height LSI >90%, n = 23) groups according to symmetry of single-leg vertical jump height, while 24 healthy athletes acted as a control (CONT) group. One-way analysis of variance was used to compare the kinematic and kinetic characteristics of the LJH, HJH, and CONT groups during single-leg vertical jump.

Results:

Both the LJH and HJH groups demonstrated greater limb asymmetry (lower LSI) during landing compared with the CONT group in knee extension moment ( P < 0.05), peak knee flexion angle ( P < 0.05), and knee power ( P < 0.05).

Conclusion:

Symmetry in single-leg vertical jump height does not represent normal lower limb biomechanics in athletes after ACLR.

Clinical Relevance:

Symmetrical jump height may not signify ideal biomechanical or RTS readiness, but single-leg vertical jump test can be used as a supplement to horizontal hop test or other functional tests to reduce the likelihood of false-negative results in the absence of detailed biomechanical evaluation.
Verification of an intravenous fluid warmer: A prospective, two-center observational trial
Authors: Lax Mikko , Mustola Seppo T. , Repo Kimmo , Järvinen Jari , Bayoro Danielle K. , Cataldo Steven H. , Karhinen Viivi , Rose Edward A. , Groepenhoff Herman , Waldmann Andreas D.
Published: August 2023

Objectives:

Avoiding inadvertent hypothermia during surgery is important. Intravenous fluid warmers used intraoperatively are critical for maintaining euthermia. We sought to prospectively evaluate the performance of the parylene-coated enFlow™ intravenous fluid warmer in patients undergoing surgery.

Methods:

This was a prospective two-center observational clinical trial performed in inpatient surgical services of two large academic hospital systems. After written informed consent, patients were enrolled in the trial. All patients were adults scheduled for a surgery that was expected to last for at least 1 h with the administration of at least 1 L of fluid warmed prior to infusion. Patient temperature was recorded in the preoperative unit, at the induction of anesthesia, and then every 15 or 30 min until the end of surgery. Temperature monitoring continued in the recovery unit. The parylene-coated enFlow™ intravenous fluid warmer was used in addition to the usual patient warming techniques. The primary outcome was the average core temperature, and secondary analyses assessed individual temperature measurements, temperature measurements during specific time periods, and rate of hypothermic events.

Results:

In all, 50 patients (29 males) with a mean age of 64 years were included in the analysis. The mean surgical time was 195 min and patients received an average of 1142 mL of fluids. Core temperature dropped by only 0.3°C approximately 60 min after induction and recovered back to the baseline level approximately 60 min later. There was no correlation between flow rate and measured core body temperature.

Conclusions:

The parylene-coated enFlow intravenous fluid warmer was able to warm fluids at all flow rates during prolonged surgery. The results showed that enFlow performed as expected.
The use of three-dimensional navigation and advanced intraoperative imaging in minimally invasive pelvic and acetabular fracture fixation: A systematic review
Authors: Bosakhar Batool , Nairn Leah , Liu Kathy , Chapleau Julien , Williams Dale , Johal Herman
Published: August 2023

Pelvic and acetabular fractures are challenging injuries to treat. This review evaluates three-dimensional intraoperative imaging and navigation-guided percutaneous SI, trans-iliac, trans-sacral, and acetabular screw placement versus conventional methods performed with C-arm imaging. A systematic search of MEDLINE, Embase, and Cochrane was performed. Two reviewers independently extracted data into a collaborative data form designed a priori and piloted prior to its use. Descriptive statistics are presented where applicable. Summary statistics analysis was presented based on the fracture type. Continuous data such as fluoroscopic and operative time were compared with unpaired Student t-test and pooled data of revision rate and complications were compared with chi-square analysis with an alpha set at 0.05. The rate of complications using conventional fluoroscopy was 11.3% (26/230) compared to three-dimensional navigation (6.7% (40/597), X2 (DF: 1, N = 827) = 4.79, p = .028.) which translated to a higher rate of revision surgeries in the conventional fluoroscopy group (10.9% vs. 0.8%) X2 (DF: 1, N = 827) = 47.8, p ≤.001. Average fluoroscopic time was lower for studies using three-dimensional navigation (28.8 ± 14.3 s, n = 71) compared to conventional fluoroscopy (57.8 ± 4.2 s, n = 38, p ≤.001). Three-dimensional navigation during minimally invasive pelvis and acetabular fracture fixation may have some benefits. Level of evidence: IV.
Diagnostic Needle Arthroscopy of the Shoulder: A Validation Study
Authors: Chowdhury Alex , Gibson Catherine , Nicholls Alex , MacLeod Iain , Colaco Henry
Published: August 2023

Background:

Diagnostic needle arthroscopy offers an alternative imaging modality to magnetic resonance imaging (MRI) for the diagnosis of intra-articular pathology.

Purpose:

To compare the accuracy of a needle arthroscopy device (Mi-eye2) versus MRI in identifying intra-articular anatomic abnormalities in the glenohumeral joint, with formal arthroscopy as the gold standard.

Study Design:

Cohort study; Level of evidence, 2.

Methods:

A total of 22 patients underwent diagnostic needle arthroscopy of the shoulder, of whom 20 had preoperative MRI scans. A standardized 12-point noninstrumented diagnostic arthroscopy was performed on each patient using the 0° needle arthroscope, followed by a 30°, 4 mm–diameter conventional arthroscope. Intraoperative images were randomized and reviewed by 2 independent blinded fellowship-trained shoulder surgeons for identification of key pathology and anatomic structures. The MRI scans were reviewed by a single musculoskeletal radiologist to identify pathology in the same key areas.

Results:

For the identification of rotator cuff pathology, needle arthroscopy (sensitivity, 0.75; specificity, 1.00) was superior to MRI (sensitivity, 0.75; specificity, 0.75) with an interobserver reliability (κ) of 0.703. For long head of the biceps pathology, needle arthroscopy (sensitivity, 0.67; specificity, 0.95) was superior to MRI (sensitivity, 0.00; specificity, 0.83). It was less accurate for labral (sensitivity, 0.33; specificity, 0.50; κ = 0.522) and articular cartilage pathology (sensitivity, 0.00; specificity, 0.94; κ = 0.353). The number of anatomic structures that could be clearly identified was 8.35 of 12 (69.58%) for needle arthroscopy versus 10.35 of 12 (86.25%) for standard arthroscopy.

Conclusion:

Diagnostic needle arthroscopy was found to be more accurate than MRI for the diagnosis of rotator cuff and long head of the biceps pathology but was less accurate for diagnosing labral and cartilage pathology. Although the field of view of a 0° needle arthroscope is not equivalent to a 30° conventional arthroscope, it presents an alternative with potential for use in an outpatient setting.
Association Between Femoral Anteversion and Distal Femoral Morphology in Patients With Patellar Dislocation and Trochlear Dysplasia
Authors: Chen Xiaobo , Ji Gang , Xu Chenyue , Wang Fei
Published: August 2023

Background:

Increased femoral anteversion (FA) is reportedly associated with patellar dislocation (PD) and trochlear dysplasia (TD), and the increase in FA may occur at different segments of the femur. In addition, TD is associated with dysplasia of the posterior femoral condyle. Among patients with PD, whether FA is greater with or without TD remains unclear.

Purpose:

To explore differences in FA and torsion distribution at different femoral sections among patients with PD and TD, patients with PD and no TD, and sex- and age-matched controls and to investigate the association between FA and distal femoral morphology.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

This study involved 132 knees: 44 knees with PD and TD, 44 knees with PD but no TD, and 44 control knees. FA, proximal torsion (PT), middle torsion (MT), distal torsion (DT), and distal femoral morphology were measured. Differences were investigated by 1-way analysis of variance. Pearson correlation analysis was conducted to explore the association between FA and each parameter.

Results:

FA was significantly larger in the PD with TD group (25.4° ± 4.7°) than in the other groups (controls: 18.9° ± 5.6°; PD without TD: 19.9° ± 4.8°) ( P < .01). DT was significantly larger in the PD with TD group (15.8° ± 2.9°) than in the other groups (controls: 9.0° ± 4.3°; PD without TD: 8.8° ± 3.9°) ( P < .01). In all 3 groups, FA was strongly positively correlated with DT (control, PD without TD, and PD with TD, respectively: r = 0.76, 0.80, and 0.88; P < .01), strongly positively correlated with the posteromedial condylar length ( r = 0.48, 0.48, and 0.70; P < .01) and negatively correlated with the posterolateral condylar length ( r = −0.30, −0.35, and −0.78, respectively; P < .05).

Conclusion:

The increased FA in knees with TD was due mainly to DT rather than PT or MT, which may provide a reference for choosing the optimal position for femoral derotation osteotomy.
Creating Value for Sustainability by Transforming the Food Well-being Paradigm—Alternative New Food Product Development
Authors: Tian Yating , Kamran Qeis
Published: August 2023

Due to supply chain disruptions and sourcing uncertainties, multinational and large food manufacturers, retailers and suppliers are investing in New Food Product Development (NFPD) to add value and differentiate themselves from homogeneous food markets. However, for start-up food companies, especially in the NFPD field and within marketing research, this is difficult to do. This article’s aim is to analyse a microalgae milk pioneer and proteinalternative food technology company, its emerging NFPD, and its focused values, highlighting the differences with prior evolutions. A design science methodology and case study are applied. The findings show that technologydriven NFPD, with an integrative process, is promising. Moreover, a diversified and plant-based NFPD is encouraged as it creates sustainability values for consumer well-being by enhancing food technology and business performance. This study contributes to the NFPD literature and marketing research by improving current understandings of how to implement sustainability through technological breakthroughs and innovation in the NFPD process. In addition, it makes a methodological contribution by means of demonstrating how design science can help researchers think outside the box and create practical research to provide valuable solutions. Finally, this is the first study to use design science guidelines to create the NFPD value chain framework.
Pheochromocytoma in a Pediatric Patient: A Case Report
Authors: Nedwick Amanda
Published: August 2023

A pheochromocytoma is a rare catecholamine secreting neuroendocrine tumor, originating within the adrenal medulla. Most cases present with a hypertensive crisis and a classic triad of headaches, sweating, and palpitations. A positive prognosis is projected for patients after operative removal of the tumor. Early detection of this tumor is crucial as it can be fatal if left untreated. Clinical signs and symptoms, diagnostic criteria, and imaging appearances are described to assist in this case of a pheochromocytoma, detected in a pediatric patient. A 16-year-old female presented to the hospital with symptoms of chest pain, hypertensive crisis, and vision loss. A renal sonogram was performed and revealed a left sided adrenal mass. Correlating the sonogram with magnetic resonance imaging (MRI), tumor markers, and clinical presentation confirmed this pathology as a benign pheochromocytoma in a pediatric patient with hypertension. Medical and surgical intervention was provided to yeild a positive outcome for this patient.