bluuebunny/crossref_metadata_2025 huggingface dataset:
Krüppel-like factors in tumors: Key regulators and therapeutic avenues
Authors: Zhang Yuchen , Yao Chongjie , Ju Ziyong , Jiao Danli , Hu Dan , Qi Li , Liu Shimin , Wu Xueqing , Zhao Chen
Published: January 2023

Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with multiple essential functions in various cellular processes, including proliferation, migration, inflammation, and angiogenesis. The aberrant expression of KLFs is often found in tumor tissues and is essential for tumor development. At the molecular level, KLFs regulate multiple signaling pathways and mediate crosstalk among them. Some KLFs may also be molecular switches for specific biological signals, driving their transition from tumor suppressors to promoters. At the histological level, the abnormal expression of KLFs is closely associated with tumor cell stemness, proliferation, apoptosis, and alterations in the tumor microenvironment. Notably, the role of each KLF in tumors varies according to tumor type and different stages of tumor development rather than being invariant. In this review, we focus on the advances in the molecular biology of KLFs, particularly the regulations of several classical signaling pathways by these factors, and the critical role of KLFs in tumor development. We also highlight their strong potential as molecular targets in tumor therapy and suggest potential directions for clinical translational research.
Phenotypic plasticity of malignant T cells in blood and skin of a Sézary syndrome patient revealed by single cell transcriptomics
Authors: Peiffer Lukas , Gambichler Thilo , Buus Terkild B. , Horny Kai , Gravemeyer Jan , Furtmann Frauke , Spassova Ivelina , Kubat Linda , Susok Laura , Stranzenbach René , Srinivas Nalini , Ødum Niels , Becker Jürgen C.
Published: January 2023

Background

Sézary Syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL). In SS patients, malignant T cells are circulating through the blood and cause erythroderma.

Objective

To compare the transcriptome of single cells in blood and skin samples from a patient with advanced SS.

Methods

We utilized combined single cell RNA and T-cell receptor (TCR) sequencing (scRNA-seq).

Results

We scrutinized the malignant T cells in blood and skin in an unbiased manner without pre-sorting of cells. We observed different phenotypes of the same monoclonal malignant T-cell population, confirmed by TCR sequencing and inferred copy number variation analysis. Malignant T cells present in the circulating blood expressed genes resembling central memory T cells such as CCR7, IL7R and CD27. In the skin, we detected two major malignant T-cell populations: One subpopulation was closely related to the malignant T cells from the blood, while the other subpopulation expressed genes reminiscent of skin resident effector memory T cells including GZMB and NKG7. Pseudotime analysis indicated crucial transcriptomic changes in the transition of malignant T cells between blood and skin. These changes included the differential regulation of TXNIP, a putative tumor suppressor in CTCL, and the adaptation to the hypoxic conditions in the skin. Tumor cell proliferation in the skin was supported by stimulating interactions between myeloid cells and malignant T cells.

Conclusions

Using scRNA-seq we detected a high degree of functional heterogeneity within the malignant T-cell population in SS and highlighted crucial differences between SS cells in blood and skin.
Rapid progression of subcutaneous glioblastoma: A case report and literature review
Authors: Wang Fang , Dong Jiawei , Zhang Jiheng , Zhao Hongtao , Wang Nan , Jin Jiaqi , Yan Xiuwei , Gao Xin , Liu Han , Hu Shaoshan
Published: January 2023

Extra-neural spread of glioblastoma (GBM) is extremely rare. We report a case of postoperative intracranial GBM spreading to the subcutaneous tissue via the channel of craniotomy defect in a 73-year-old woman. Radiological images and histopathology indicate that the tumor microenvironment of the subcutaneous tumor is clearly different from the intracranial tumor. We also model the invasion of GBM cells through the dura-skull defect in mouse. The retrospective analysis of GBM with scalp metastases suggests that craniectomy is a direct cause of subcutaneous metastasis in patients with GBM. Imaging examinations of other sites for systemic screening is also recommended to look for metastases outside the brain when GBM invades the scalp or metastasizes to it.
Extreme temperature events reduced carbon uptake of a boreal forest ecosystem in Northeast China: Evidence from an 11-year eddy covariance observation
Authors: Yan Yujie , Zhou Li , Zhou Guangsheng , Wang Yu , Song Jiaxin , Zhang Sen , Zhou Mengzi
Published: January 2023

Boreal forests, the second continental biome on Earth, are known for their massive carbon storage capacity and important role in the global carbon cycle. Comprehending the temporal dynamics and controlling factors of net ecosystem CO2 exchange (NEE) is critical for predicting how the carbon exchange in boreal forests will change in response to climate change. Therefore, based on long-term eddy covariance observations from 2008 to 2018, we evaluated the diurnal, seasonal, and interannual variations in the boreal forest ecosystem NEE in Northeast China and explored its environmental regulation. It was found that the boreal forest was a minor CO2 sink with an annual average NEE of -64.01 (± 24.23) g CO2 m-2 yr-1. The diurnal variation in the NEE of boreal forest during the growing season was considerably larger than that during the non-growing season, and carbon uptake peaked between 8:30 and 9:30 in the morning. The seasonal variation in NEE demonstrated a “U” shaped curve, and the carbon uptake peaked in July. On a half-hourly scale, photosynthetically active radiation and vapor pressure deficit had larger impacts on daytime NEE during the growing season. However, temperature had major control on NEE during the growing season at night and during the non-growing season. On a daily scale, temperature was the dominant factor controlling seasonal variation in NEE. Occurrence of extreme temperature days, especially extreme temperature events, would reduce boreal forest carbon uptake; interannual variation in NEE was substantially associated with the maximum CO2 uptake rate during the growing season. This study deepens our understanding of environmental controls on NEE at multiple timescales and provides a data basis for evaluating the global carbon budget.
Qualitative motivation with sets and relations
Authors: Ünlü Ali
Published: January 2023

In self-determination theory (SDT), multiple conceptual regulations of motivation are posited. These forms of motivation are especially qualitatively viewed by SDT researchers, and there are situations in which combinations of these regulations occur. In this article, instead of the commonly used numerical approach, this is modeled more versatilely by sets and relations. We discuss discrete mathematical models from the theory of knowledge spaces for the combinatorial conceptualization of motivation. Thereby, we constructively add insight into a dispute of opinions on the unidimensionality vs. multidimensionality of motivation in SDT literature. The motivation order derived in our example, albeit doubly branched, was approximately a chain, and we could quantify the combinatorial details of that approximation. Essentially, two combinatorial dimensions reducible to one were observed, which could be studied in other more popular scales as well. This approach allows us to define the distinct, including even equally informative, gradations of any regulation type. Thus, we may identify specific forms of motivation that may otherwise be difficult to measure or not be separable empirically. This could help to dissolve possible inconsistencies that may arise in applications of the theory in distinguishing the different regulation types. How to obtain the motivation structures in practice is demonstrated by relational data mining. The technique applied is an inductive item tree analysis, an established method of Boolean analysis of questionnaires. For a data set on learning motivation, the motivation spaces and co-occurrence relations for the gradations of the basic regulation types are extracted, thus, enumerating their potential subforms. In that empirical application, the underlying models were computed within each of the intrinsic, identified, introjected, and external regulations, in autonomous and controlled motivations, and the entire motivation domain. In future studies, the approach of this article could be employed to develop adaptive assessment and training procedures in SDT contexts and for dynamical extensions of the theory, if motivational behavior can go in time.
Exploring the use of music to promote physical activity: From the viewpoint of psychological hedonism
Authors: Park Kyoung Shin , Williams David M. , Etnier Jennifer L.
Published: January 2023

Despite the global efforts to encourage people to regularly participate in physical activity (PA) at moderate-to-vigorous intensity, an inadequate number of adults and adolescents worldwide meet the recommended dose of PA. A major challenge to promoting PA is that sedentary or low-active people experience negative shifts in affective valence (feeling bad versus good) in response to moderate-to-vigorous intensity PA. Interestingly, empirical data indicate that listening to music during acute bouts of PA positively alters affective valence (feeling good versus bad), reduces perceived exertion, and improves physical performance and oxygen utilization efficiency. From the viewpoint of the ancient principle of psychological hedonism – humans have ultimate desires to obtain pleasure and avoid displeasure – we elaborate on three putative mechanisms underlying the affective and ergogenic effects of music on acute bouts of PA: (1) musical pleasure and reward, (2) rhythmic entrainment, and (3) sensory distraction from physical exertion. Given that a positive shift in affective valence during an acute bout of PA is associated with more PA in the future, an important question arises as to whether the affective effect of music on acute PA can be carried over to promote long-term PA. Although this research question seems intuitive, to our knowledge, it has been scarcely investigated. We propose a theoretical model of Music as an Affective Stimulant to Physical Activity (MASPA) to further explain the putative mechanisms underlying the use of music to promote long-term PA. We believe there have been important gaps in music-based interventions in terms of the rationale supporting various components of the intervention and the efficacy of these interventions to promote long-term PA. Our specification of relevant mechanisms and proposal of a new theoretical model may advance our understanding of the optimal use of music as an affective, ergogenic, and sensory stimulant for PA promotion. Future directions are suggested to address the gaps in the literature.
The impact of the digital economy on occupational health: A quasi-experiment based on “Broadband China” pilot
Authors: Wang Fanfan , Wang Zheng
Published: January 2023

The recent years' booming digital economy can not only benefit businesses, but also be an important way to improve people's wellbeing. This paper aimed to identify the relationship between the digital economy based on the “Broadband China” pilot policy and occupational health by applying DID method. The empirical results highlight that occupational health in the pilot cities of “Broadband China” are significantly improved compared with those in non-pilot cities, indicating that the digital economy can significantly improve occupational health. However, this effect varies across regions with different levels of economic development. Compared with developed areas, the digital economy has a more obvious effect on the improvement of occupational health in less developed areas, which indicates that this effect conforms to the law of diminishing marginal effect. Therefore, the digital economy should be continuously promoted to improve occupational health. Governments at all levels should strengthen the network infrastructure to provide a good basic environment for the development of the digital economy. At the same time, governments should introduce more detailed digital economy goals and programs according to the actual situation of their jurisdictions to fully release the economic and social benefits of the digital economy.
Associations between air pollutant and pneumonia and asthma requiring hospitalization among children aged under 5 years in Ningbo, 2015–2017
Authors: Zhou Xingyuan , Guo Min , Li Zhifei , Yu Xiping , Huang Gang , Li Zhen , Zhang Xiaohong , Liu Liya
Published: January 2023

Introduction

Exposure to ambient air pollutants is associated with an increased incidence of respiratory diseases such as pneumonia and asthma, especially in younger children. We investigated the relationship between rates of hospitalization of children aged under 5 years for pneumonia and asthma and the concentration of air pollutants in Ningbo between January 1, 2015 and August 29, 2017.

Methods

Data were obtained from the Ningbo Air Quality Data Real-time Publishing System and the big data platform of the Ningbo Health Information Center. A generalized additive model was established via logarithmic link function and utilized to evaluate the effect of pollutant concentration on lag dimension and perform sensitivity analysis.

Results

A total of 10,301 cases of pneumonia and 115 cases of asthma were identified over the course of this study. Results revealed that PM2.5, PM10, SO2 and NO2 were significantly associated with hospitalization for pneumonia and asthma in children under 5 years of age. For every 10-unit increase in lag03 air pollutant concentration, hospitalization for pneumonia and asthma due to PM2.5, PM10, SO2 and NO2 increased by 2.22% (95%CI: 0.64%, 3.82%), 1.94% (95%CI: 0.85%, 3.04%), 11.21% (95%CI: 4.70%, 18.10%) and 5.42% (95%CI: 3.07%, 7.82%), respectively.

Discussion

Adverse effects of air pollutants were found to be more severe in children aged 1 to 5 years and adverse effects due to PM2.5, PM10 and SO2 were found to be more severe in girls. Our findings underscore the need for implementation of effective public health measures to urgently improve air quality and reduce pediatric hospitalizations due to respiratory illness.
Arizona Surge Line: An emergent statewide COVID-19 transfer service with equity as an outcome
Authors: Villarroel Lisa , Tams Erin , Smith Luke , Rigler Jessica , Wilson Dena , Hu Chengcheng , Glassberg Marilyn K.
Published: January 2023

Introduction

The Arizona Surge Line was an emergent initiative during the COVID-19 pandemic to facilitate COVID-19 patient transfers and load-level hospitals on a statewide level. It was designed and implemented by the Arizona Department of Health Services in preparation for the first hospital surge due to COVID-19, recognizing the disproportionate impact that hospital surge would have on rural and tribal populations.

Methods

We analyzed the Arizona Surge Line transfer data for the state's first two COVID-19 surges (4/16/2020–3/6/2021). Transfer data included transfer request characteristics, patient demographics and participating hospital characteristics. When applicable, we compared this data with Arizona census data, COVID-19 case data, and the CDC/ATSDR Social Vulnerability Index. The primary outcomes studied were the proportion of COVID-19 patient requests being successfully transferred, the median transfer time, and the proportion of vulnerable populations impacted.

Results

During the period of study, 160 hospitals in Arizona made 6,732 requests for transfer of COVID-19 patients. The majority of these patients (84%, 95% CI: 83–85%) were placed successfully with a median transfer time of 59 min (inter-quartile range 33–116). Of all transfer requests, 58% originated from rural hospitals, 53% were for patients of American Indian/Alaska Native ethnicity, and 73% of patients originated from highly vulnerable areas. The majority (98%) of receiving facilities were in urban areas. The Arizona Surge Line matched the number of transfers with licensed market shares during the period of study.

Conclusions

The Arizona Surge Line is an equity-enhancing initiative that disproportionately benefited vulnerable populations. This statewide transfer infrastructure could become a standard public health mechanism to manage hospital surges and enhance access to care during a health emergency.
Urban–sub-urban–rural variation in the supply and demand of emergency medical services
Authors: Li Yue , Li Ji , Geng Jiayu , Liu Tao , Liu Xin , Fan Haojun , Cao Chunxia
Published: January 2023

Background

Emergency medical services (EMSs) are a critical component of health systems, often serving as the first point of contact for patients. Understanding EMS supply and demand is necessary to meet growing demand and improve service quality. Nevertheless, it remains unclear whether the EMS supply matches the demand after the 2016 healthcare reform in China. Our objective was to comprehensively investigate EMS supply–demand matching, particularly among urban vs. sub-urban vs. rural areas.

Methods

Data were extracted from the Tianjin Medical Priority Dispatch System (2017–2021). From supply and demand perspectives, EMS resources and patient characteristics were analyzed. First, we performed a descriptive analysis of characteristics, used Moran's I to explore the spatial layout, and used the Gini coefficient to evaluate the equity of EMS supply and demand. Second, we analyzed urban–sub-urban–rural variation in the characteristics of EMS supply and demand by using the chi-square test. Finally, we examined the association between the EMS health resource density index and the number of patients by using the Spearman correlation and divided supply–demand matching types into four types.

Results

In 2021, the numbers of medical emergency stations and ambulances were 1.602 and 3.270 per 100,000 population in Tianjin, respectively. There were gradients in the health resource density index of the number of emergency stations (0.260 vs. 0.059 vs. 0.036; P = 0.000) in urban, sub-urban, and rural areas. There was no spatial autocorrelation among medical emergency stations, of which the G values by population, geographical distribution, and the health resource density index were 0.132, 0.649, and 0.473, respectively. EMS demand was the highest in urban areas, followed by sub-urban and rural areas (24.671 vs. 15.081 vs. 3.210 per 1,000 population and per year; P = 0.000). The EMS supply met the demand in most districts (r = 0.701, P = 0.003). The high supply–high demand types with stationary demand trends were distributed in urban areas; the low supply–high demand types with significant demand growth trends were distributed in sub-urban areas; and the low supply–low demand types with the highest speed of demand growth were distributed in rural areas.

Conclusion

EMS supply quantity and quality were promoted, and the supply met the demand after the 2016 healthcare reform in Tianjin. There was urban–sub-urban–rural variation in EMS supply and demand patterns.
Management of in- and out-of-hospital screening for hepatitis C
Authors: Zhou Jing , Wang Fa-Da , Li Lan-Qing , Chen En-Qiang
Published: January 2023

Because of insidious progression and no significant clinical symptoms at early stage, chronic hepatitis C (CHC) is often diagnosed after the occurrence of cirrhosis and hepatocellular carcinoma. Highly effective and low drug resistance of direct-acting antiviral agents (DAAs) have enabled cure of CHC, encouraging the World Health Organization to propose a global viral hepatitis elimination program. To Date, vaccine for CHC is still under research. Therefore, reducing the source of infection is an important means of eliminating CHC other than cutting off the transmission route, which requires screening, diagnosing and treating as many patients in the population as possible. Hospital-based screening strategy have been found to be cost-effective in the management of CHC screening, as reported both nationally and internationally. Currently, China has issued In-hospital process for viral hepatitis C screening and management in China (Draft) in April, 2021, which provides a standardized implementation process and direction for in-hospital hepatitis C screening and treatment, but still requires medical institution to develop its own management process, taking into account its current situation and learning from domestic and international experience. In addition, screening for CHC outside the hospital among special populations, such as blood donors, pregnant women, homosexuals, intravenous drug users, prisoners, and residents in rural areas with scarce medical care resources, also requires attention and development of targeted and rational screening strategies. In this paper, we analyze and recommend the management of hepatitis C screening from both in-hospital and out-of-hospital perspectives, with the aim of contributing to the formulation of hepatitis C screening strategies.
The association of park use and park perception with quality of life using structural equation modeling
Authors: Kodali Hanish P. , Ferris Emily B. , Wyka Katarzyna , Evenson Kelly R. , Dorn Joan M. , Thorpe Lorna E. , Huang Terry T.-K.
Published: January 2023

Introduction

The literature is limited on the impact of neighborhood parks on quality of life (QoL) and the mechanism linking them.

Methods

In this paper, we applied the structural equation model to data from a cross-sectional sample of 650 participants in low-income communities of New York City, we examined the associations of neighborhood park use vs. park perception and QoL, and whether these associations were mediated through self-reported perceived stress. We also examined whether park use mediated the relationship between park perception and QoL.

Results

We found that park use had a significant but weak association with QoL (standardized β = 0.08, 95% confidence interval (CI): 0.02, 0.15, p = 0.02), but this relationship was not mediated by self-reported stress. Park perception was more strongly associated with QoL than park use (standardized β = 0.23, 95% CI: 0.16, 0.30, p < 0.01), and this was partly mediated by self-reported stress (indirect effect- standardized β = 0.08, 95% CI: 0.03, 0.13, p < 0.01) and, to a lesser extent, by park use (indirect effect- standardized β = 0.01, 95% CI: 0.00, 0.02, p = 0.01).

Discussion

Having well-perceived parks appears to be an important factor for QoL independent of park use, suggesting that quality parks may benefit everyone in a community beyond park users. This strengthens the argument in favor of increasing park investment as a strategy to improve population wellbeing.
Learning from pandemic responses: Informing a resilient and equitable health system recovery in Thailand
Authors: Tangcharoensathien Viroj , Vandelaer Jos , Brown Richard , Suphanchaimat Rapeepong , Boonsuk Phiangjai , Patcharanarumol Walaiporn
Published: January 2023

This article is part of the Research Topic ‘Health Systems Recovery in the Context of COVID-19 and Protracted Conflict’. The third quarter of 2022 saw COVID-19 cases and deaths in Thailand reduced significantly, and high levels of COVID-19 vaccine coverage. COVID-19 was declared an “endemic” disease, and economic activities resumed. This paper reviews pre-pandemic health systems capacity and identifies pandemic response strengths, weaknesses and lessons that guided resilient and equitable health system recovery. Robust health systems and adaptive strategies drive an effective pandemic response. To support health system recovery Thailand should (1) minimize vulnerability and extend universal health coverage to include migrant workers and dependents; (2) sustain provincial primary healthcare (PHC) capacity and strengthen PHC in greater Bangkok; (3) leverage information technology for telemedicine and teleconsultation; (4) enhance and extend case and event-based surveillance of notifiable diseases, and for public health threats, including pathogens with pandemic potential in wildlife and domesticated animals. This requires policy and financial commitment across successive governments, adequate numbers of committed and competent health workforce at all levels supported by over a million village health volunteers, strong social capital and community resilience. A strengthened global health architecture and international collaboration also have critical roles in establishing local capacities to develop and manufacture pandemic response products through transfer of technology and know-how. Countries should engage in the ongoing Inter-government Negotiating Body to ensure a legally binding instrument to safeguard the world from catastrophic impacts of future pandemics.
Building back better children's surgical services toward universal health coverage: Perspectives from Bangladesh and Zimbabwe
Authors: Mazingi Dennis , Chowdhury Tanvir Kabir , Aziz Tasmiah Tahera , Tamanna Nowrin , Lakhoo Kokila , Banu Tahmina , Mustafa Saqif
Published: January 2023

Introduction

This article is part of the Research Topic ‘Health Systems Recovery in the Context of COVID-19 and Protracted Conflict’. Children's surgical services are crucial, yet underappreciated, for children's health and must be sufficiently addressed to make and sustain progress toward universal health coverage (UHC). Despite their considerable burden and socioeconomic cost, surgical diseases have been relatively neglected in favor of communicable diseases living up to their inauspicious moniker: ‘the neglected stepchild of global health'. This article aims to raise awareness around children's surgical diseases and offers perspectives from two prototypical LMICs on strengthening surgical services in the context of health systems recovery following the COVID-19 experience to make and sustain progress toward UHC.

Approach

We used a focused literature review supplemented by the perspectives of local experts and the 6-components framework for surgical systems planning to present two case studies of Bangladesh and Zimbabwe. The lived experiences of the authors are used to describe the impact of COVID-19 on respective surgical systems and offer perspectives on building back the health system and recovering essential health services for sustainability and resilience.

Findings

We found that limited high-level policy and planning instruments, an overburdened and under-resourced health and allied workforce, underdeveloped surgical infrastructure (from key utilities to essential medical products), lack of locally generated research, and the specter of prohibitively high out-of-pocket costs for children's surgery are common challenges in both countries that have been exacerbated by the COVID-19 pandemic.

Discussion

Continued chronic underinvestment and inattention to children's surgical diseases coupled with the devastating effect of the COVID-19 pandemic threaten progress toward key global health objectives. Urgent attention and investment in the context of health systems recovery is needed from policy to practice levels to improve infrastructure; attract, retain and train the surgical and allied health workforce; and improve service delivery access with equity considerations to meet the 2030 Lancet Commission goals, and make and sustain progress toward UHC and the SDGs.
Transmission of tuberculosis in an incarcerated population during the subclinical period: A cross-sectional study in Qingdao, China
Authors: Wang Zhongdong , Li Haoran , Song Song , Sun Haiyan , Dai Xiaoqi , Chen Meng , Xu Honghong , Zhang Huaqiang , Pang Yu
Published: January 2023

Objectives

As a closed gathering place, prison is the cradle of tuberculosis (TB) outbreak. Therefore, the analysis of the prevalence rate and risk factors of latent tuberculosis infection (LTBI) in prison will be a necessary measure to intervene in the spread of tuberculosis.

Methods

In this study, we consecutively recruited 506 adult prisoners in Qingdao to carry out this cross-sectional study. TB and LTBI were screened by IGRA, X-ray, X-pert, sputum smear and culture.

Results

A total of 17 TB, 101 LTBI and 388 HC were identified, with an infection rate of 23.32% (118/506) and a TB incidence rate of 3282/100,000 population. Age, malnutrition and inmates living with TB prisoners were risk factors for LTBI. Additionally, most TB cases (70.59%, 12/17) were subclinical tuberculosis (STB), contributing significantly to TB transmission.

Conclusion

Our results demonstrate that the transmission efficiency of asymptomatic patients is not essentially different from that of symptomatic patients, indicating that TB transmission occurs during the subclinical period. Our findings highlight the need to strengthen active case-finding strategies to increase TB case detection in this population.
Social support, positive caregiving experience, and caregiver burden in informal caregivers of older adults with dementia
Authors: Nemcikova Marta , Katreniakova Zuzana , Nagyova Iveta
Published: January 2023

Introduction

Dementia is currently one of the major causes of disability and dependency among older adults worldwide. Cognitive dysfunction, neuropsychiatric symptoms, somatic complaints, and functional impairment fundamentally affect not only a person living with dementia (PLwD), but also his/her informal caregiver(s), often resulting in a high caregiver burden. A number of variables, including the caregiver's sociodemographic characteristics, the clinical characteristics of PLwD, social support, and the caregiver's personal resources determine the caregiver's burden.

Objectives

The aim of this study was to investigate the associations of caregiver burden in informal caregivers of PLwD with perceived social support, positive caregiving experience, and applying therapeutic communication methods.

Methods

The data were collected from September 2021 to February 2022 among 115 “PLwD—informal caregiver” dyads in the community settings in Slovakia. Measures included the Zarit Burden Interview (ZBI-12), the Oslo Social Support Scale (OSSS-3), the Positive Aspects of Caregiving Scale (PACS), and two questions on applying therapeutic communication methods—reminiscence and validation according to Naomi Feil. The Short IQCODE was used for assessing cognitive decline in PLwD. Pearson's and Spearman's correlations, t-tests, Chi-square, ANOVA, and linear multiple regression analyses were used to analyze the data (IBM SPSS 27).

Results

The mean age of informal caregivers was 54 ± 12.4 years (81.7% of women) and the mean caregiving duration was 4.8 ± 4.8 years. The mean age of PLwD was 80.5 ± 8.3 years (73.0% of women) and their Short IQCODE mean score was 4.1 ± 1.0. Lower caregiving burden was significantly associated with higher perceived social support (β = 0.33, p < 0.01), with higher positive caregiving experience (β = 0.33, p < 0.01), and higher caregiving intensity (β = 0.24, p < 0.05) among informal caregivers of PLwD. The associations between caregiver burden and applying two therapeutic communication methods were not significant.

Conclusions

Implementing psycho-social and educational public health interventions focused on strengthening social support and maintaining positive perceptions of caregiving can help reduce the increased risk of caregiver burden in informal caregivers of older adults with dementia.
Vulcano: A new robotic challenge for legged robots
Authors: Domingos Manuel , Pedro Francisco , Ramos Alberto , Funk Matthias G. , Mendes Armando , Cascalho José
Published: January 2023

The Vulcano challenge is a new and innovative robotic challenge for legged robots in a physical and simulated scenario of a volcanic eruption. In this scenario, robots must climb a volcano’s escarpment and collect data from areas with high temperatures and toxic gases. This paper presents the main idea behind this challenge, with a detailed description of the simulated and physical scenario of the volcano ramp, the rules proposed for the competition, and the conception of a robot prototype, Vulcano, used in the competition. Finally, it discusses the performance of teams invited to participate in the challenge in the context of Azorean Robotics Open, the Azoresbot 2022. This first test for this challenge provided insights into what the participants found exciting and positive and what they found less positive.
Theory-based behavioral change interventions to improve periodontal health
Authors: Chan Charlotte C. K. , Chan Alice K.Y. , Chu C.H. , Tsang Y. C.
Published: January 2023

Periodontal disease is a significant global health burden affecting half of the world's population. Given that plaque and inflammation control are essential to the attainment of periodontal health, recent trends in preventive dentistry have focused on the use of behavioral models to understand patient psychology and promote self-care and treatment compliance. In addition to their uses in classifying, explaining and predicting oral hygiene practices, behavioral models have been adopted in the design of oral hygiene interventions from individual to population levels. Despite the growing focus on behavioral modification in dentistry, the currently available evidence in the field of periodontology is scarce, and interventions have primarily measured changes in patient beliefs or performance in oral hygiene behaviors. Few studies have measured their impact on clinical outcomes, such as plaque levels, gingival bleeding and periodontal pocket reduction, which serve as indicators of the patient's disease status and quality of oral self-care. The present narrative review aims to summarize selected literature on the use of behavioral models to improve periodontal outcomes. A search was performed on existing behavioral models used to guide dental interventions to identify their use in interventions measuring periodontal parameters. The main models were identified and subsequently grouped by their underlying theoretical area of focus: patient beliefs (health belief model and cognitive behavioral principles); stages of readiness to change (precaution adoption process model and transtheoretical model); planning behavioral change (health action process approach model, theory of planned behavior and client self-care commitment model); and self-monitoring (self-regulation theory). Key constructs of each model and the findings of associated interventions were described. The COM-B model, a newer behavioral change system that has been increasingly used to guide interventions and policy changes, is discussed with reference to its use in oral health settings. Within the limitations of the available evidence, interventions addressing patient beliefs, motivation, intention and self-regulation could lead to improved outcomes in periodontal health. Direct comparisons between interventions could not be made due to differences in protocol design, research populations and follow-up periods. The conclusions of this review assist clinicians with implementing psychological interventions for oral hygiene promotion and highlight the need for additional studies on the clinical effects of behavioral model-based interventions.
Tips for writing a good recommendation letter
Authors: Burrell Angeline G. , Jones McArthur , Zawdie Kate A. , Coxon John C. , Halford Alexa J.
Published: January 2023

Bias exists in letters of recommendation, and it is reflected in the language used to describe and evaluate different candidates for countless opportunities in academia. Professional organizations are becoming more aware of this issue, and are pursuing avenues to address it. This paper discusses the type of information, that is, useful to have on hand when writing a recommendation letter, the structure of the letter, a process to follow for proof reading, when to say no, a compilation of additional resources, and tips for people asking for recommendation letters. Specifically, we discuss common grammar mistakes, the purpose of each portion of the letter, and ways conscious and unconscious bias can influence wording and structure. This paper is intended to provide a single place where people can go to learn all of the basics needed to write a strong recommendation letter, as currently available letter writing resources in the space physics community tend to focus on one aspect of letter writing.
Subtle impairments of perceptual-motor function and well-being are detectable among military cadets and college athletes with self-reported history of concussion
Authors: Wilkerson Gary B. , Colston Marisa A. , Acocello Shellie N. , Hogg Jennifer A. , Carlson Lynette M.
Published: January 2023

Introduction

A lack of obvious long-term effects of concussion on standard clinical measures of behavioral performance capabilities does not preclude the existence of subtle neural processing impairments that appear to be linked to elevated risk for subsequent concussion occurrence, and which may be associated with greater susceptibility to progressive neurodegenerative processes. The purpose of this observational cohort study was to assess virtual reality motor response variability and survey responses as possible indicators of suboptimal brain function among military cadets and college athletes with self-reported history of concussion (HxC).

Methods

The cohort comprised 75 college students (20.7 ± 2.1 years): 39 Reserve Officer Training Corp (ROTC) military cadets (10 female), 16 football players, and 20 wrestlers; HxC self-reported by 20 (29.2 ± 27.1 months prior, range: 3–96). A virtual reality (VR) test involving 40 lunging/reaching responses to horizontally moving dots (filled/congruent: same direction; open/incongruent: opposite direction) was administered, along with the Sport Fitness and Wellness Index (SFWI) survey. VR Dispersion (standard deviation of 12 T-scores for neck, upper extremity, and lower extremity responses to congruent vs. incongruent stimuli originating from central vs. peripheral locations) and SFWI response patterns were the primary outcomes of interest.

Results

Logistic regression modeling of VR Dispersion (range: 1.5–21.8), SFWI (range: 44–100), and an interaction between them provided 81% HxC classification accuracy (Model χ2[2] = 26.03, p < .001; Hosmer & Lemeshow χ2[8] = 1.86, p = .967; Nagelkerke R2 = .427; Area Under Curve = .841, 95% CI: .734, .948). Binary modeling that included VR Dispersion ≥3.2 and SFWI ≤86 demonstrated 75% sensitivity and 86% specificity with both factors positive (Odds Ratio = 17.6, 95% CI: 5.0, 62.1).

Discussion/Conclusion

Detection of subtle indicators of altered brain processes that might otherwise remain unrecognized is clearly important for both short-term and long-term clinical management of concussion. Inconsistency among neck, upper extremity, and lower extremity responses to different types of moving visual stimuli, along with survey responses suggesting suboptimal well-being, merit further investigation as possible clinical indicators of persisting effects of concussion that might prove to be modifiable.
A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology
Authors: Planinc Ivo , Ilic Ivana , Dejea Hector , Garcia-Canadilla Patricia , Gasparovic Hrvoje , Jurin Hrvoje , Milicic Davor , Skoric Bosko , Stampanoni Marco , Bijnens Bart , Bonnin Anne , Cikes Maja
Published: January 2023

Endomyocardial biopsies are the gold standard for surveillance of graft rejection following heart transplantation, and are assessed by classical histopathology using a limited number of previously stained slices from several biopsies. Synchrotron propagation-based X-ray phase contrast imaging is a non-destructive method to image biological samples without tissue preparation, enabling virtual 2D and 3D histopathology. We aimed to show the feasibility of this method to assess acute cellular rejection and its agreement to classical histopathology. Right ventricular biopsies were sampled from 23 heart transplantation recipients (20 males, mean age 54±14 years) as part of standard follow-up. The clinical diagnosis of potential rejection was made using classical histopathology. One additional study sample was harvested and imaged by X-ray phase contrast imaging, producing 3D datasets with 0.65 μm pixel size, and up to 4,320 images per sample. An experienced pathologist graded both histopathological and X-ray phase contrast images in a blinded fashion. The agreement between methods was assessed by weighted kappa, showing substantial agreement (kappa up to 0.80, p < 0.01) between X-ray phase contrast imaging and classical histopathology. X-ray phase contrast imaging does not require tissue processing, allows thorough analysis of a full myocardial sample and allows identification of acute cellular rejection.
Handshake Feedback in a Haptic Glove Using Pouch Actuators
Authors: Yamaguchi Seiya , Hiraki Takefumi , Ishizuka Hiroki , Miki Norihisa
Published: January 2023

In this paper, we propose and demonstrate a haptic device with liquid-pouch motors that can simulate a handshake. Because handshakes involve contact of the palms or soft skin, handshake simulation requires the haptic device to provide pressure onto specific areas of the palm with soft contact. This can be achieved with thermally driven liquid-pouch motors, which inflate and deflate when a low-boiling-point liquid, here Novec™ 7000, evaporates and condenses, respectively. Due to the simplicity of the soft actuator system, this haptic glove is lightweight and conformable. To design the haptic glove, we experimentally investigated the contact region and strength in handshakes, which led to an optimal number, size and position for the liquid-pouch motors. Sensory experiments with human subjects verified that the designed haptic glove successfully simulated handshakes.
Parameter Analysis and Experiment Validation of Deployment Characteristics of a Rectangular Tether-Net
Authors: Yue Shuai , Li Mengsheng , Zhao Zhen , Du Zhonghua , Wu Chunbo , Zhang Qingzhan
Published: January 2023

Tether-nets in space applications are flexible capture systems for removing space debris. A new, low-mass, rectangular tether-net deployed by ten towing blocks is proposed in this paper for the purpose of capturing the main body of satellites. The dynamic model of a rectangular tether-net during the deployment process was established. The accuracy of the simulation model was validated by comparing it with on-ground experiments. In addition, the influence of towing block mass and launch speed on the maximum deployment area and the deployment lengths of the long side and short side of the rectangular tether-net were systematically analyzed. The results show that the tether-net configuration and launch distance of the simulations were consistent with those of the experiments, demonstrating the good accuracy of the simulation model. Moreover, with the increase in towing block mass, the maximum deployment area and deployment lengths of both sides of the rectangular tether-net showed a gradually increasing tendence, while the recoil impulse and structural weight increased. When the launch speed of the towing blocks increased, the maximum deployment area and deployment lengths increased significantly and further caused the extension of the shape-preserving distance.
Long-Term Studies of Wheat Leaf Rust in the North-Western Region of Russia
Authors: Gultyaeva Elena , Gannibal Philipp , Shaydayuk Ekaterina
Published: January 2023

Leaf rust, caused by Puccinia triticina (Pt), is a widely occurring disease of wheat in the North-Western Region of Russia. Annual Pt surveys of wheat in this region have been conducted between 2001 and 2021. In total, 740 single urediniospore isolates were analyzed over 20 years. Virulence to Lr9, Lr19 and Lr24 were rare in 2001–2010 and was not detected after 2010. Temporal variation in virulence was determined on Thatcher lines with Lr1, Lr2a, Lr2b and Lr2c genes and was found to be relatively high. Virulence to Lr1 increased to 100% from 2001 to 2014. Until 2010, most northwestern Pt isolates were avirulent to Lr2a and virulent to Lr2b and Lr2c. In the middle of 2010, avirulence to Lr2a, Lr2b, Lr2c and Lr15 began to increase. Strong variability between years was revealed for virulence to Lr20 and Lr26. Based on a set of 20 differential lines, 122 virulence pathotypes were detected. More than half of those were observed only once across all years. Pathotypes were divided into groups of B-, C-, D- and F-, virulent to Lr1 and Lr2a, dominating until 2009. From 2010 pathotype groups M- and P-, virulent to Lr1 and avirulent to Lr2a, began to dominate. Temporal differentiation of northwestern Pt population for virulence was determined. High similarity was observed for Pt accessions in 2001–2009 and 2010–2015 and these two groups differed moderately from each other. Pt accessions from 2016–2019 and 2020–2021 differed from each other and from accessions from the previous collection period. Field response of Lr differential lines was studied in the North-Western Region during 1998–2022. Wheat genotypes with genes Lr9, Lr19, Lr23, Lr24, Lr25, Lr28, Lr29, Lr35, Lr39, Lr42, Lr43, Lr45, Lr47, Lr48, Lr49, Lr50, Lr51, Lr53 and Lr57 remained resistant throughout the period of the study. Leaf rust severity in lines TcLr12, TcLr21, TcLr22a, Gatcher (Lr27+31), TcLr44 and Pavon (Lr46) varied from 1% to 30% before 2014 and significantly decreased after 2014. A general trend of decreasing virulence of the Pt pathogen has been observed in the North-Western Region over the recent years.
Multi-Environment Trials and Stability Analysis for Yield-Related Traits of Commercial Rice Cultivars
Authors: Lee Seung Young , Lee Hyun-Sook , Lee Chang-Min , Ha Su-Kyung , Park Hyang-Mi , Lee So-Myeong , Kwon Youngho , Jeung Ji-Ung , Mo Youngjun
Published: January 2023

Multi-environment trials (METs) are essential in plant breeding programs to evaluate crop productivity and adaptability in diverse environments. In this study, we demonstrated the practical use of METs to evaluate grain yield and yield-related traits using 276 Korean rice cultivars, divided into three maturity groups (81 early-, 90 medium-, and 105 medium–late-maturing cultivars) grown in three regions (Jeonju, Suwon, and Miryang) and two planting seasons (early and regular planting) for two years. Due to the narrow genetic variability of the commercial cultivars, which are cultivated in relatively similar environmental conditions, genotype-by-environment interaction (GEI) effects were not statistically significant. However, genotype and environment evaluation using GGE biplot analysis exhibited distinct patterns of mega-environment formation, winning genotypes, ranking genotypes, discriminating power, and representativeness according to the differences in planting seasons and regions. Moreover, the simultaneous selection of stable high-performance genotypes using a weighted average of absolute scores from the singular-value decomposition of the matrix of BLUPs (WAASB) and a multi-trait stability index (MTSI) revealed six recommended genotypes each for early-maturing (Manho, Namil, Unkwang, Odae 1ho, Sinunbong 1ho, and Jonong) and medium-maturing (Sobi, Cheongdam, Shinbaeg, Boramchal, Mimyeon, and Saemimyeon) cultivars, and four genotypes for medium–late-maturing cultivars (Hanmauem, Dami, Baegseolchal, and Hangangchalbyeo). The winning genotypes of each trait can be used as parents to develop regional specialty cultivars by fine-tuning favorable traits, and recommended genotypes can be utilized as elite climate-resilient parents that can aid breeders in improving yield potential and stability across the planting seasons and regions.