bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Persistensi Penggunaan Obat Antidiabetik Terhadap Pencapaian Gula Darah Optimal Pada Pasien di Puskesmas
Authors: Bella Shinta , Nurmainah Nurmainah , Andrie Mohammad
Published: March 2024

DM sufferers in Indonesia lack awareness of using drugs regularly and continuously or in clinical terms known as persistence. The persistence of using antidiabetic drugs for 1 year is known to be low (65%). This study aims to analyze the relationship between patient characteristics, patient therapy factors and drug factors used by patients that can affect the persistence of antidiabetic drug use in outpatient type 2 diabetes mellitus patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. This study uses a retrospective cohort study design and uses secondary data sources for outpatient type 2 diabetes mellitus patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. The persistence measurement method used is the gaps between refill method with a grace period of 14 days for taking the drug. Data were analyzed using chi square test. The number of subjects used were 206 patients with type 2 diabetes mellitus who used antidiabetic drugs (June 2020-June 2021). The results showed that the majority of the characteristics of patients with type 2 diabetes mellitus who visited the Sungai Raya Dalam Public Health Center tended to be 40-60 years old (68.4%), female (54.9%), patients with monotherapy therapy regimen (76.7%). %), patients with metformin (72.3%) and patients with uncontrolled blood sugar (67.5%). Only (43.2%) of patients persistently used antidiabetic drugs. Chi square analysis showed that there was a significant difference between the age factor (p = 0.036), there was no significant difference between gender (p = 0.425), treatment regimen (p = 0.452) and type of therapy (P = 0.121). The conclusion of this study is that the persistence of drug use is influenced by the therapeutic regimen and the type of antidiabetic drug given.
Analisis Pengelolaan Obat di Puskesmas X Provinsi Kalimantan Selatan
Authors: Anisah Nida , Yunita Sendi Lia , Ratna Hidayati Ika
Published: March 2024

Drug is an important aspect that needs to be considered in health services. Proper drug management is needed so that the availability of drugs is guaranteed and the quality of drugs is maintained. The purpose of this study was to determine drug management which includes planning, requesting, receiving and storing drugs at X Health care Center. This research is a quantitative research with a descriptive observational research design, using secondary data sources LPLPO and RKO as well as primary data sources by direct observation and 13 indicators were used. The results of the analysis of indicators of conformity of items with Fornas 91.10%, accuracy of planning 18.14%, suitability of items and number of requests 105% and 37.18%, suitability of items and number of receipts 96.83%, storage according to dosage forms 99.19% , storage according to pharmacology 0%, storage in alphabetical order 98.37%, storage according to temperature 97,56%, storage of narcotics and psychotropics according to regulations 83.33%, storage of drugs not used for other storages that cause contamination 100%, arrangement paying attention to FEFO 100% , 83.33% high-alert drug storage, 88% LASA drug storage. It can be concluded that drug management at the X Health Center has met the standard in some indicators.
Prevalensi Kejadian Infeksi HIV Sebagai Screening Test Deteksi AIDS Dengan Metode Imunokromatografi Pada Komunitas Homoseksual
Authors: Erawati Erawati Erawati , Kusumawardani Siska , Anggraini Puspita Sari Leni
Published: March 2024

Human Immunodeficiency Virus (HIV) is a virus that can cause AIDS by attacking white blood cells, namely Cluster Of Differentiation 4 (CD4) cells so it can damage the human immune system. After several years the number of viruses increases so that the immune system is no longer able to fight the incoming disease. Acquired Immuno Deficiency Syndrome (AIDS) often manifests with various opportunistic infections, malignancies, metabolic disorders and others. Homosexual men have a greater risk of contracting HIV/AIDS than heterosexual men, particularly through risky sexual behavior, namely sex with more than one partner and anal sex. This study aims to determine the presence or absence of HIV antibodies in the Homosexual Community at the Pesantren I Public Health Center, Kediri City. The research design used is descriptive research design with quota sampling technique. In HIV testing using the Immunochromatography method with whoole blood the Homosexual Community of Gay. The principle of the examination is a qualitative test method by looking at the color changes on the test strip. The results of the study of 30 respondents, there were 2 positive results of HIV antibodies with a percentage of 7% and 28 negative results of HIV antibodies with a percentage of 93%. The conclusion of this study is that HIV examination using the immunochromatographic method can be used to detect the presence of HIV antibodies and can be used as a screening test for AIDS detection in the Homosexual Community.
Hubungan Kepatuhan Konsumsi Kalsium Karbonat terhadap Kadar Fosfat Pasien Gagal Ginjal dengan Hemodialisis
Authors: Ramadhani Fika Nuzul
Published: March 2024

Non-adherence to renal failure treatment increases the risk of disease complications, such as metabolic disorders of calcium and phosphate. Education is one of way to increase medication adherence. Education is one way to increase patient compliance in therapy. One way of conducting education is by giving leaflets. This study aims to determine the correlation between compliance with consumption of calcium carbonate and phosphate levels in patients with kidney failure on hemodialysis. This research were experimental and prospective study at PKU Muhammadiyah General Hospital, Yogyakarta City for 4 weeks using the one-group pretest posttest design to test patients' phosphate levels pre and post administation of leaflets increase adherence. Sample consisted of 70 kidney disease patients with hemodialysis were divided into 2 groups, each consisting of 35 patients. The intervention group were given education leaflets and checking phosphate levels, while the control group were not given leaflets. Data were obtained from medical records, questionnaire instruments and phosphate laboratory data. The level of patient adherence in taking calcium carbonate medication assessed by MMAS questionnaire and phosphate levels of patients. Data were analysis using the Wilcoxon test and Spearman test.The results of the analysis between adherence and phosphate levels showed no relationship between adherence and phosphate levels p=0.591 (p0.05). Overall, it can be concluded that there is no correlation between adherence to calcium carbonate consumption and phosphate levels
Studi Penjaminan Mutu (Quality Assurance) Internal Dalam Pelayanan Kefarmasian
Authors: Madania Madania , Andy Suryadi A. Mu’thi , Hiola Faramita , Marjun Rahmawati
Published: March 2024

Pharmaceutical services in hospitals aim to improve the quality of pharmaceutical services, protect patients from irrational drug use to maintain patient safety, and ensure legal certainty for pharmacists. Quality Assurance (QA) is used in measuring service quality, whereas QA in IFRS aims to provide assurance of product quality and the quality of pharmaceutical services provided to patients. This research employs descriptive research with a cross-sectional method, and primary date are obtained from questionnaires with the framework of QA standard indicators in pharmaceutical services at the primary Installastion of Mother and Child Hospital Kasih Fatimah Kotamobagu, with five respondents. The results indicate that internal quality assurance in pharmaceutical services at the Fatimah Kotamobagu Mother and Child Hospital Kasih Fatimah Kotamobagu Pharmacy Installation was in accordance with quality assurance standards, especially in the aspects of organizational structure, quality measures, and safety assurance, as well as drug distribution with an overall value in the criteria, are (75%), moderately appropriate are (15%) and not appropriate are (10%).
Skrining Fitokimia dan Uji Antioksidan Ekstrak Daun Cabai Rawit (Capsicum frutescens L.)
Authors: Fatwami Esti Febri , Royani Sri
Published: March 2024

Chili is a plant that is widely cultivated in indonesia. Chili leaves are knowon to have many health benefits. This has something to do with the content of secondary metabolites in it. This research was conducted to determine the content of secondary metabolites in chili leaves. The method used was in the form of phytochemical screening and antioxidant activity test using the DPPH method. The identification of the phytochemicals carried out included the identification of alkaloids, flavanoids, saponins, triterpenoids, quinones and phenols. The results of the phytochemical screening showed that the compounds contained in cayenne pepper leaf extract that extracted using 96% alcohol were alkaloids, flavonoids, and phenols. While the antioxidant test results on cayyenne pepper leaf extract showed an IC50 value of 78,03 µg/ml.
Uji Aktivitas Sediaan Sampo Antiketombe Ekstrak Daun Ketepeng Cina (Cassia alata L) Terhadap Jamur Pityrosporum ovale
Authors: Suryani Ade Irma , Rohwah Eneng Ikrimah
Published: March 2024

Dandruff is a health problem that is often experienced by most people because it can reduce self-confidence. The aim of this research is to determine the extract of Chinese ketepeng leaves (Cassia alata L) as an anti-dandruff shampoo preparation and to determine the activity of the shampoo against Pityrosporum ovale and Candida albicans fungi using laboratory experimental methods. This research is divided into three concentration variations, namely 10% - 15% 20% and two supporting controls, namely control (-) without extract and control (+), namely ketomed shampoo. Results: The results of the research for the inhibitory power of the fungus Pityrosporum ovale without extract (-) have a value of 4.43 mm at a concentration of 10% have an inhibition zone of 17.23 mm at a concentration of 15% have an inhibitory zone value of 18.67 mm at a concentration of 20% have the value of the inhibition zone is 19.66 mm in the control (+) which has a value of 20.87 mm. In Candida albicans without extract (-) it has a value of 2.33 mm at a concentration of 10% it has an inhibition zone value of 16.44 mm at a concentration of 15% it has an inhibition zone value of 17.76 mm at a concentration of 20% it has an inhibition zone value of 19.37 mm at control (+) has a value of 20.54 mm. Chinese ketepeng (Cassia alata L.) leaf extract can be used as an anti-dandruff shampoo, based on the results of the preparation evaluation it was found that the formula with a concentration of 15% meets the characteristics of a good shampoo, and the flavonoid compound content in Chinese Ketapang (Cassia alata L.) leaf extract is 15% has a high zone of inhibition against P. ovale and C. albicans fungi. So it can be concluded that the best formula obtained in this study was at an extract concentration of 15%.
ВИКЛИКИ ДЛЯ ПЕНСІЙНИХ СИСТЕМ КРАЇН ЄС І УКРАЇНИ НА СУЧАСНОМУ ЕТАПІ РОЗВИТКУ СУСПІЛЬСТВА
Authors: Рудик В. К.
Published: March 2024

Національні пенсійні системи країн ЄС і України відіграють важливу роль у системі соціального захисту населення. Зростаючі потреби громадян пенсійного віку зумовлюють необхідність постійного підвищення їхніх пенсійних доходів, що спонукає уряди країн до пошуку додаткових джерел фінансування пенсійних виплат. Тенденції, які відбуваються в демографічній сфері, прояви фінансових криз у масштабах світового господарства, військові дії на території України формують нові виклики для подальшого ефективного функціонування пенсійних систем країн ЄС і України. Вони дають об’єктивні підстави для їх подальшого реформування і удосконалення, що підвищує науковий інтерес до дослідження даних питань. Метою статті є характеристика багаторівневих пенсійних систем, що сформувалися в країнах ЄС і Україні, аналіз процесів в суспільстві, які впливають на необхідність їх подальшого реформування і визначення додаткових джерел фінансування сфери пенсійного забезпечення громадян. При проведенні наукових досліджень використовувалися відповідні економічні методи, спеціальна економічна література, наукові праці вітчизняних і зарубіжних вчених, документи спеціалізованих міжнародних фінансових інститутів, що стосуються питань функціонування національних пенсійних систем європейських країн, їх нормативно правового забезпечення. Дослідження пенсійних систем країн ЄС показують, що вони представляють багаторівневі пенсійні моделі. Україна, відповідно до вітчизняного пенсійного законодавства, також формує трьохрівневу пенсійну систему. Визначено, що використання перерозподільчих і накопичувальних пенсійних програм дає можливість громадянам європейських країн, при досягненні ними пенсійного віку, одержувати кілька видів пенсій. Великі розміри пенсій в країнах Європи у порівнянні з нашою державою підтверджують ефективність багаторівневих пенсійних систем. Проаналізовано основні виклики для суспільства, які впливають на фінансове забезпечення пенсійних систем,здійснена їх характеристика. Особливу увагу звернуто на сучасний етап реформування пенсійних систем і питань, що стосуються підвищення пенсійного віку громадян, розмірів страхових пенсійних внесків, впливу фінансових криз на пенсійну сферу. В Україні проаналізовано особливості функціонування пенсійної системи в умовах військового стану, можливості її фінансового забезпечення.
ІМУНОКОРЕКЦІЯ ОРГАНІЗМУ КОРІВ ЗА ГІПОФУНКЦІЇ ЯЄЧНИКІВ
Authors: Боднар О. О.
Published: March 2024

В роботі дано теоретичне обґрунтування та проведено клінічну перевірку комплексних схем лікування корів за гіпофункції яєчників із залученням імунокорегуючих препаратів. Метою досліджень було вивчити динаміку деяких показників крові та імунного статусу організму корів з функціональними розладами яєчників під впливом біостимулюючих препаратів. Матеріалом для досліджень були корови української молочної чорно-рябої породи з діагнозом гіпофункція яєчників, що проявлялося анафродизією. Результати досліджень підтвердили та доповнили встановлені раніше дані про зміни гематологічних та імунологічних показників організму корів за гіпофункції яєчників. Установлено, що розвиток даної патології супроводжувався імунодефіцитом, розладами клітинної і гуморальної ланок імунітету, зниженням показників неспецифічного захисту організму. Оваріальна гіпофункція корів переважно розвивається на тлі імуносупресії, зниженням вмісту в крові еритроцитів, гемоглобіну та загального білка, що вказує на необхідність застосування біостимулюючої терапії. Проведений аналіз динаміки показників імунного статусу дозволяє зробити висновок про різнобічну та специфічну імунотропну дію застосованих біопрепаратів. Отримані дані свідчать, що застосування біогенних стимуляторів (гемостимулюючої сироватки, молозива, препарату АСД-ф-2) сприяє нормалізації вмісту Т- і В-лімфоцитів, підвищує функціональну активність імунокомпетентних клітин. Застосування біостимуляторів спричинило позитивний вплив на динаміку імунокомпетентних клітин крові хворих тварин усіх дослідних груп; по закінченні лікування вони практично зрівнялися із контрольними показниками. Найбільший імунокорегуючий вплив на організм хворих корів проявило сумісне введення молозива з препаратом АСД-ф-2, про що свідчить високий рівень активації факторів імунного і неспецифічного захисту, нормалізація показників гомеостазу їх організму та відновлення репродуктивної функції корів.
Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19
Authors: Brilakis Leonidas , Theofilogiannakou Eirini , Lykoudis Panagis M
Published: March 2024

During the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, particular interest rose regarding the interaction between metabolic dysfunction-associated fatty liver disease (MAFLD) and the COVID-19 infection. Several studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical outcomes. One of the proposed mechanisms is the inflammatory response pathway, especially the one involving cytokines, such as interleukin 6, which appeared particularly elevated in those patients and was deemed responsible for additional insult to the already damaged liver. This should increase our vigilance in terms of early detection, close follow up and early treatment for individuals with MAFLD and COVID-19 infection. In the direction of early diagnosis, biomarkers such as cytokeratin-18 and scoring systems such as Fibrosis-4 index score are proposed. COVID-19 is a newly described entity, expected to be of concern for the years to come, and MAFLD is a condition with an ever-increasing impact. Delineating the interaction between these two entities should be brought into the focus of research. Reducing morbidity and mortality of patients with COVID-19 and MAFLD should be the ultimate objective, and the optimal way to achieve this is by designing evidence-based prevention and treatment policies.
Advancements in Barrett's esophagus detection: The role of artificial intelligence and its implications
Authors: Massironi Sara
Published: March 2024

Artificial intelligence (AI) is making significant strides in revolutionizing the detection of Barrett's esophagus (BE), a precursor to esophageal adenocarcinoma. In the research article by Tsai et al , researchers utilized endoscopic images to train an AI model, challenging the traditional distinction between endoscopic and histological BE. This approach yielded remarkable results, with the AI system achieving an accuracy of 94.37%, sensitivity of 94.29%, and specificity of 94.44%. The study's extensive dataset enhances the AI model's practicality, offering valuable support to endoscopists by minimizing unnecessary biopsies. However, questions about the applicability to different endoscopic systems remain. The study underscores the potential of AI in BE detection while highlighting the need for further research to assess its adaptability to diverse clinical settings.
Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis
Authors: Zhou Xing-Nian , Zhang Quan , Peng Hong , Qin Yu-Jie , Liu Yu-Hong , Wang Lu , Cheng Ming-Liang , Luo Xin-Hua , Li Hong
Published: March 2024

BACKGROUND

Acute liver failure (ALF) has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis. The silent information regulator sirtuin 1 (SIRT1)-mediated deacetylation affects multiple biological processes, including cellular senescence, apoptosis, sugar and lipid metabolism, oxidative stress, and inflammation.

AIM

To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms.

METHODS

This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) testing. C57BL/6 mice were also intraperitoneally pretreated with SIRT1, p53, or glutathione peroxidase 4 (GPX4) inducers and inhibitors and injected with lipopolysaccharide (LPS)/D-galactosamine (D-GalN) to induce ALF. Gasdermin D (GSDMD)-/- mice were used as an experimental group. Histological changes in liver tissue were monitored by hematoxylin and eosin staining. ALT, AST, glutathione, reactive oxygen species, and iron levels were measured using commercial kits. Ferroptosis- and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain reaction. SIRT1, p53, and GSDMD were assessed by immunofluorescence analysis.

RESULTS

Serum AST and ALT levels were elevated in patients with ALF. SIRT1, solute carrier family 7a member 11 (SLC7A11), and GPX4 protein expression was decreased and acetylated p5, p53, GSDMD, and acyl-CoA synthetase long-chain family member 4 (ACSL4) protein levels were elevated in human ALF liver tissue. In the p53 and ferroptosis inhibitor-treated and GSDMD-/- groups, serum interleukin (IL)-1β, tumour necrosis factor alpha, IL-6, IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was mitigated. In mice with GSDMD knockout, p53 was reduced, GPX4 was increased, and ferroptotic events (depletion of SLC7A11, elevation of ACSL4, and iron accumulation) were detected. In vitro , knockdown of p53 and overexpression of GPX4 reduced AST and ALT levels, the cytostatic rate, and GSDMD expression, restoring SLC7A11 depletion. Moreover, SIRT1 agonist and overexpression of SIRT1 alleviated acute liver injury and decreased iron deposition compared with results in the model group, accompanied by reduced p53, GSDMD, and ACSL4, and increased SLC7A11 and GPX4. Inactivation of SIRT1 exacerbated ferroptotic and pyroptotic cell death and aggravated liver injury in LPS/D-GalN-induced in vitro and in vivo models.

CONCLUSION

SIRT1 activation attenuates LPS/D-GalN-induced ferroptosis and pyroptosis by inhibiting the p53/GPX4/GSDMD signaling pathway in ALF.
Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication
Authors: Li Jun-Tao , Zhang Hong-Mei , Wang Wei , Wei Dong-Qing
Published: March 2024

BACKGROUND

Liver cancer is one of the deadliest malignant tumors worldwide. Immunotherapy has provided hope to patients with advanced liver cancer, but only a small fraction of patients benefit from this treatment due to individual differences. Identifying immune-related gene signatures in liver cancer patients not only aids physicians in cancer diagnosis but also offers personalized treatment strategies, thereby improving patient survival rates. Although several methods have been developed to predict the prognosis and immunotherapeutic efficacy in patients with liver cancer, the impact of cell-cell interactions in the tumor microenvironment has not been adequately considered.

AIM

To identify immune-related gene signals for predicting liver cancer prognosis and immunotherapy efficacy.

METHODS

Cell grouping and cell-cell communication analysis were performed on single-cell RNA-sequencing data to identify highly active cell groups in immune-related pathways. Highly active immune cells were identified by intersecting the highly active cell groups with B cells and T cells. The significantly differentially expressed genes between highly active immune cells and other cells were subsequently selected as features, and a least absolute shrinkage and selection operator (LASSO) regression model was constructed to screen for diagnostic-related features. Fourteen genes that were selected more than 5 times in 10 LASSO regression experiments were included in a multivariable Cox regression model. Finally, 3 genes (stathmin 1, cofilin 1, and C-C chemokine ligand 5) significantly associated with survival were identified and used to construct an immune-related gene signature.

RESULTS

The immune-related gene signature composed of stathmin 1, cofilin 1, and C-C chemokine ligand 5 was identified through cell-cell communication. The effectiveness of the identified gene signature was validated based on experimental results of predictive immunotherapy response, tumor mutation burden analysis, immune cell infiltration analysis, survival analysis, and expression analysis.

CONCLUSION

The findings suggest that the identified gene signature may contribute to a deeper understanding of the activity patterns of immune cells in the liver tumor microenvironment, providing insights for personalized treatment strategies.
Precisión diagnóstica de la circunferencia de cuello para la predicción de sobrepeso y obesidad en estudiantes universitarios mexicanos
Authors: Valbuena-Gregorio Edith , Márquez Ibarra Adriana Alejandra , López-Mata Marco Antonio , González Ponce Ana María
Published: March 2024

La circunferencia de cuello es una medida de fácil acceso y bajo costo, que podría ayudar a la identificación del sobrepeso u obesidad. Objetivo. Determinar la precisión diagnóstica de la circunferencia de cuello para la predicción de sobrepeso y obesidad en estudiantes universitarios mexicanos y analizar la correlación entre la circunferencia de cuello con otros indicadores antropométricos y la presión arterial como factor de riesgo cardiovascular. Materiales y métodos. Estudio transversal, analítico en 236 universitarios. Se realizaron mediciones antropométricas y presión arterial. Se realizaron análisis de las curvas ROC para obtener la sensibilidad y especificidad de los puntos de corte para la predicción de sobrepeso u obesidad y correlaciones de Pearson de circunferencia de cuello vs variables antropométricas. Resultados. Se observó, en hombres y mujeres, una correlación fuerte entre circunferencia de cuello y peso [r= 0,74 y r= 0,82 (p<0,01), respectivamente], seguida por IMC [r= 0,77 y r= 0,75 (p<0,01), respectivamente], circunferencia de cintura [r= 0,73 y r= 0,77 (p<0,01), respectivamente] e ICT [r= 0,71 y r= 0,73 (p<0,01), respectivamente]; se encontraron correlaciones moderadas para porcentaje de masa grasa y tensión arterial. La circunferencia de cuello vs circunferencia de cintura fue la mejor prueba de predicción para asociar el sobrepeso u obesidad tanto en hombres (AUC= 0,93; 89,3% sensibilidad y 82,3% especificidad) como mujeres (AUC= 0,95: 94,3% sensibilidad y 82,3% especificidad). Conclusiones. Los puntos de corte de la circunferencia de cuello presentan una adecuada capacidad para predecir el sobrepeso y obesidad en jóvenes adultos mexicanos.
A HISTORY OF ASSISTANT RESEARCH
Authors:   Teacher, assistant at Uzbekistan -Finnish Pedagogical Institute, Uzbekistan, Utkirovna Erbotaveva Shalola
Published: March 2024

In this article, views on the history of the study of units related to the auxiliary group in world and Uzbek linguistics are analyzed, and the compounds included in the scope of this group, taken as the object of research, have been studied since the earliest times.
UNDERSTANDING POSTMODERNISM THROUGH THE THEORIES OF LYOTARD AND BAUDRILLARD
Authors:   Doctor of Science in Philological Sciences, Associate Professor, Department of English Literary and Translation Studies, Foreign Languages Faculty, Bukhara State University, Uzbekistan, Feruza Khajieva , Shakhnoza Rakhimova ,   MA student of Bukhara State University, Department of English Literary and Translation Studies, Foreign Languages Faculty, Bukhara State University, Uzbekistan
Published: March 2024

This article studies the profound transformations ushered in by postmodernism in the mid-20th century, focusing on its impact on culture, truth, representation, and the traditional understanding of knowledge. Contrary to the view of postmodernism as a linear progression from modernism, we explore the perspectives of Jean-Francois Lyotard and Jean Baudrillard, presenting it as a cyclical moment within the continuous innovation of high modernism. Lyotard redefines the role of postmodern artists and writers as akin to philosophers, liberated from pre-established norms and engaged in a perpetual quest fornew rules within their works. Baudrillard’s insights into the evolution of science fiction reflect a broader postmodern reevaluation of reality as fragmented and simulacral. Furthermore, we address the so-called crisis of representation identified by Lyotard, challenging the realistic epistemology that views knowledge and art as mirrors of an external reality. By examining fragmented narration in literature, we propose a more inclusive approach to representing the multifaceted nature of reality. This article contributes to the understanding of postmodernism, highlighting its significance in redefining cultural expressions and our approach to knowledge and representation.
Action control costs in task selection: Agents avoid actions with incompatible movement and effect features
Authors: Neszmélyi Bence , Pfister Roland
Published: March 2024

When a movement triggers effects with incompatible features, conflict between action and effect features creates costs for action planning and initiation. We investigated whether such action control costs also factor into action choices in terms of the principle of least effort. Participants completed a reaction-time experiment, where they were instructed to perform left and right mouse swipes in response to directional cues presented on the screen. Participants could select between two action options on each trial: Depending on which part of the screen (upper or lower) the action was performed in, the swipe resulted in a visual stimulus moving in the same (compatible) or in the opposite (incompatible) direction as the mouse. Incompatible action–effect mappings did indeed incur action control costs. In accordance with effort avoidance, the proportion of compatible choices was significantly above chance level, suggesting that action selection and initiation costs factor into participants preferences. Interestingly, however, participants’ choice tendencies were not predicted by the actual increase in action-initiation costs in the incompatible condition. This indicates that effort-related decisions are not simply based on monitoring performance in the actual task, but they are also influenced by preestablished notions of action-planning costs.
KEBIJAKAN MAKING INDONESIA 4.0 DALAM UPAYA MENINGKATKAN KUALITAS SUMBER DAYA MANUSIA (SDM) YANG KOMPETEN
Authors: Astuti Ismaya Indri , Stiawati Titi
Published: March 2024

Revolusi Industri 4.0 merupakan sesuatu yang tidak dapat dihindari, untuk dapat terus bertahan dalam situasi tersebut Indonesia perlu beradaptasi menghadapi perubahan dan tantangan tersebut. Komitmen Pemerintah Indonesia memasuki era Revolusi Industri 4.0 ditunjukan dengan diluncurkannya gerakan Making Indonesia 4.0. Roadmap Making Indonesia 4.0 diperuntukkan sebagai upaya negara Indonesia agar dapat mempersiapkan diri dalam bersaing dengan industri global. Kebijakan Making Indonesia 4.0 salah satunya berfokus pada peningkatan kualitas Sumber Daya Manusia (SDM). Peningkatan kualitas SDM dilakukan melalui pendidikan vokasi dan diklat berbasis kompetensi, pembangunan infrastruktur tenaga kerja industri berbasis kompetensi, dan pembangunan dan pengembangan lembaga pendidikan vokasi dan diklat berbasis kompetensi. Penelitian ini menggunakan metode kualitatif, yang akan membahas tentang bagaimana implementasi kebijakan Making Indonesia 4.0, serta mengetahui program apa saja yang mendukung upaya meningkatkan kualitas Sumber Daya Manusia (SDM) Industri yang kompeten. Penelitian ini didukung dengan data-data literatur terkait dengan Making Indonesia 4.0, serta berbagai dokumen kebijakan, peraturan dan perundang-undangan berkaitan dengan Making Indonesia 4.0.
The Influence of Leadership, Motivation, Environment and Discipline on Work Performance of the North Bengkulu Argamakmur Environmental Service
Authors: Pribowo Muhamad Galy Njoman Ari , Antonius Antonius
Published: March 2024

This research is motivated by the importance of improving employee performance in order to produce quality employees. The respondents of this research are all employees of Dinas Lingkungan Hidup Argamakmur Bengkulu Utara with the total number 64 people, with the sampling method is total sampling. Data analysis techniques using multiple linear regression analysis and hypothesis testing. The results of this study indicate that the variables of work motivation, work environment and work discipline partially or individually influence employee performance with a probability value (sig) of each variable. Leadership (X1) with a probability value (sig) 0.013 <alpha 0.05 has a significant effect on work performance. Work motivation (X2) with a probability value (sig) of 0.000 < alpha 0.05 has a significant effect on work performance. Work environment (X3) with a probability value (sig) 0.042 <alpha 0.05 has a significant effect on work performance. And work discipline (X4) with a probability value (sig) 0.001 <alpha 0.05 has a significant effect on work performance.
Analysis of the Presentation of Financial Statements of a Non-Profit Organization (Case Study of Independent Private Foundation Orphanage Bengkulu City)
Authors: Susanti Neri , Noviantoro Rinto , Anggini Anggini
Published: March 2024

The characteristics of non-profit organizations are different from business organizations. The fundamental difference lies in the way the organization obtains the resources needed to carry out its various operating activities. non-profit organizations obtain resources from donations from other contributing members who do not expect anything in return from the organization while business organizations obtain resources from the capital of owners or investors who expect a return on any profits earned by the organization.This study aims to analyze the presentation of financial statements of non-profit organizations (a case study of the Bengkulu city independent private foundation orphanage). The purpose of this study was to determine the suitability of the application of ISAK 35 concerning financial statements of non-profit organizations in achieving transparency and accountability at the orphanage of the private foundation mandiri Bengkulu city. The data analysis used is descriptive comparative, which is a research method that compares a theory that applies to events that occur in the field.The results of this study indicate that the Bengkulu city independent private foundation orphanage in general has not made financial reports in accordance with ISAK 35, but in the financial statements made by the independent private foundation orphanage has implemented ISAK 35 even though it is only 55.55%, while for transparency and accountability as a whole the orphanage has been transparent and accountable, in its financial statements.
The Influence of Lifestyle and Product Quality on Consumer Purchasing Decisions at Bandung Distro Manna South Bengkulu
Authors: Putra Jiri Tri , Wijaya Ermy , Ariska Yesi Indian
Published: March 2024

The purpose of this study was to determine the influence of Lifestyle and product quality on consumer purchasing decisions in Bandung Distro Manna Bengkulu Selatan. The sample in this study were 65 consumers who shop at Bandung Distro Manna Bengkulu Selatan. The sampling technique is accidental sampling technique. Data collection using a questionnaire and the method of analysis used is multiple linear regression, determination test and hypothesis testing. The results of the Lifestyle analysis have a significant effect on consumer purchasing decisions at Bandung Distro Manna Bengkulu Selatan, this is evidenced by the results of the t test showing the tcount value is greater than ttable (6.256 > 1.669) and a significant value of 0.000 <0.05 means H_0 is rejected and H_a is accepted. Product quality has a significant effect on consumer purchasing decisions at Bandung Distro Manna Bengkulu Selatan, this is evidenced by the results of the t test showing the tcount value is greater than ttable (4.477 > 1.669) with a significant value of 0.000 <0.05 meaning H_0 is rejected and H_a is accepted. Lifestyle (X_1) and product quality (X_2) together have a significant effect on consumer purchasing decisions (Y) in the Bandung Distro Manna Bengkulu Selatan, this is evidenced by the F test showing the value of Fcount > Ftable (146.677 > 3.15) with a significant value of 0.000. The results of multiple regression have the equation Y = 7.005 + 0.512 (X_1) + 0.295 (X_2) + e, because the direction of the regression is positive, it means that if lifestyle and product quality increase, purchasing decisions at Bandung Distro Manna Bengkulu Selatan will also increase. Lifestyle is more influential than product quality on purchasing decisions because the lifestyle regression value of 0.512 is greater than the product quality regression value.
The Effect of Social Presence in Live Streaming Shopping on Tiktok Platform Users on Impulse Buying Behavior
Authors: Fara Qierana Maulidya , Hartono Arif
Published: March 2024

Social presence is a theory that explains self-involvement in social interactions. Even though it is often not realized, social presence has an important role in explaining a person's condition towards the nature of virtual interaction. The flexibility of social presence makes this theory often applied in various scientific fields such as education, tourism, marketing to other fields, especially in the current digitalization era. One of the aims of this research is to explore and reaffirm the performance of social presence within the scope of live streaming marketing by involving consumer trust as a driver of impulsive buying behavior. This study adopts the SOR theory which explains the function of stimulus, organism, and response in influencing consumer behavior. This study has five variables, namely live streaming social presence, viewer social presence, broadcaster social presence, consumer trust, and impulse buying. This research was conducted using a quantitative approach with a convenience sampling technique and collected data from 188 respondents which were processed using SPSS and PLS-SEM. The main findings of this study indicate that the social presence of live streaming and social presence of watching has a positive and significant effect on consumer trust. Furthermore, consumer confidence has a positive and significant effect on impulsive purchases. In addition, the effect of social media presence on consumer trust is negative and insignificant.
The Influence ROA, ROE, NPM, EPS and PER to Market Price on Public Listed Manufacture of Food Products 2018-2022
Authors: Sholihah Mila Hiswatus , Tjaraka Heru
Published: March 2024

This study aims to provide empirical evidence in financial ratios which include ROA, ROE, NPM, EPS and PER for significance in predicting market prices on public listed food manufacture of food products in the 2018-2022 to minimize information asymmetry, increase transparency and accuracy between management and stakeholders that occur in a stock market. The research samples in this study are public food manufacturing companies in Indonesia in 2018-2022. This study uses panel data with cross-sectional data for 45 companies and time series data from 2018-2022. The total sample in this study is 201 samples. The results of this study indicate that H1 ROA has no significant effect on market price. Meanwhile, H2 ROE, H3 NPM, H4 EPS and H5 PER have a significant effect on market price
The Role of Employee Engagement in Green HRM to Create Sustainable Humanist Performance
Authors: Dira Aldy Friyatna , Noor Gena Prasetya , Bangun Mic Finanto Ario , Winardi N Muhammad Aziz , Kamal Fahmi , Utomo Kurniawan Prambudi
Published: March 2024

The purpose of this study is to determine the role of employee involvement in Green HRM to create humanist sustainable performance as an approach that links ecological principles with human resource management in order to achieve sustainable and humane organizational performance. This research method involved surveys and data analysis using multiple linear regression analysis and distribution of questionnaires and interviews as well as literature studies, after which data processing was carried out using SPSS Analysis Version 25. from companies to identify the relationship between the level of employee involvement in sustainable initiatives. The research technique used a quantitative approach using a sample of 100 respondents and was conducted in June-August 2023, the results showed a significant positive effect on employee engagement and Green HRM variables on sustainable performance increasing productivity, employee loyalty, and company reputation as well as having a positive impact on the humanist aspect, such as job satisfaction and employee welfare. These findings underscore the need to develop a Green HRM strategy that focuses on the active participation of employees in formulating, implementing and strengthening sustainable initiatives, thereby creating a more sustainable work environment.
Analysis Of Islamic Banking Financial Performance Before And After The Merger
Authors: Frestiva Irma Juniar , Sholahuddin Muhammad
Published: March 2024

This research aims to analyze the financial performance of Islamic banking, namely BNI Syariah, BRI Syariah, and Bank Syariah Mandiri, both before and after the merger process that resulted in the formation of the new Bank Syariah Indonesia. The time period to be examined in this study encompasses the years between 2019 and 2023, with the goal of obtaining a comprehensive and detailed overview of changes in financial performance over time. The researcher will employ a quantitative approach involving the collection and analysis of numerical data. The variables to be used in this study will include financial ratios that have a close relationship with the profitability and risks experienced by Islamic banks. The research findings indicate differences in the financial performance of Islamic banking before and after the merger.
The The Mediating Role Of Trust In The Influence Of Viral Marketing And Online Consumer Reviews On Purchasing Decisions Skintific Product In TikTok
Authors: Murni Dewi , Salim Muhartini
Published: March 2024

Online shopping in Indonesia will continue to increase along with technological advances, Data collected by APJII and Suara.com shows that "more than 74% of Indonesians choose to shop online." This study aims to examine the mediating role of trust in the influence of viral marketing and online consumer reviews on purchasing decisions through trust. The data obtained by this study through a questionnaire from 100 respondents of Skintific users on TikTok. This research data is processed using SEM (Structural Equation Modeling) using the SmartPLS4 application. The results of this study are Viral Marketing has a significant impact on Trust, Online Consumer Reviews has a significant impact on Trust, Trust has a significant impact on Purchasing Decisions, Viral Marketing has a significant impact on purchasing decisions, Online Consumer Reviews has a significant impact on Purchasing Decisions, Viral Marketing has a significant impact on Purchasing Decisions through Trust, Online Consumer Reviews has a significant impact on Purchasing Decisions through Trust. The implication of this research for the Skintific company is that it is expected to always maintain a good message on Viral Marketing, create a good reputation in consumer perceptions starting from the products sold, the services provided, and other aspects that appear in TikTok media.
The Influence Of Career Development, Training, And Communication On Employee Performance At The Nusantara Sakti (NSS) Dealer In Bengkulu City
Authors: Kusuma Merta , Novaliza Dinda Ermnaya
Published: March 2024

The purpose of this research is to find out  the influence of Career Development, Training and Communication on Employee Performance at the Nusantara Sakti (NSS) Dealer in Bengkulu City. The population in this study were all employees of the Bengkulu City Dealer Nusantara Sakti (NSS), totaling 36 people and sampling using the saturated sampling method.

In this study the researcher used data collection methods by means of observation, interviews and distributing questionnaires.The data analyzed using the instrument tests , classical assumption tests, analysis of respondents' responses, multiple linear regression analysis, hypothesis testing and analysis of the coefficient of determination. The results showed that career development had a positive and significant effect on the employee performance, then training had a positive and significant effect on the employee performance and communication had a negative and insignificant effect on the employee performance due to a lack of communication between superiors and subordinates as well as fellow co-workers. So, from the results of the research,it can be concluded that career development, training and communication have a simultaneous effect on employee performance at Nusantara Sakti (NSS) Dealer of Bengkulu City. While partially the communication variable has no effect on employee performance at Nusantara Sakti (NSS) Dealer of  Bengkulu City.
The Influence of Training and Work Discipline on the Performance of PT Kereta Api Indonesia (Persero) Building Unit Employees Divre III Palembang LRT SUMSEL Maintenance Area
Authors: Agustini Triana , Pramajaya Jamilah , Singgalang Bayu
Published: March 2024

The aim of this research is to determine the Influence of Training and Work Discipline on the Performance of PT Kereta Api Indonesia (Persero) Building Unit Employees Divre III Palembang LRT SUMSEL Maintenance Area. The method used is quantitative and qualitative analysis. Quantitative analysis is a research method based on the philosophy of positivism, used to research certain populations or samples, collecting data using research instruments, data analysis is quantitative or independent, with the aim of testing established hypotheses. Quantitative Analysis is used to see the results of the questionnaire using a literary scale. Based on the test results, the coefficient of determination (Adjusted R Square) was obtained at 0.773. This shows that the training and work discipline variables influence the performance variable by 77.3%. Meanwhile, the remaining 22.7% is explained by other variables not examined in this study.
Efficiency Level Of Zakat Management In Palopo City
Authors: Ilyas Muhammad , Sari Ema , Umar Fitriana
Published: March 2024

This research aims to evaluate the level of efficiency in zakat management in the city of Palopo. Zakat is one of the fundamental pillars of Islam, designed to distribute wealth to those who are entitled to receive it. Efficiency in zakat management is crucial to ensure that the collected funds are used as efficiently as possible to support those in need. The research methodology involves the analysis of secondary data related to the collection, distribution, and management of zakat funds in the city of Palopo. These data will be analyzed to assess the extent to which zakat management in Palopo achieves the desired level of efficiency. The results of this research are expected to provide valuable insights into the efficiency of zakat management in Palopo and serve as a basis for improvements in zakat collection and distribution. This research can also serve as a guide for zakat institutions and local governments in their efforts to enhance efficiency and effectiveness in zakat management, ultimately improving the well-being of those entitled to receive zakat.
The Level Of Islamic Financial Literacy And Islamic Financial Inclusion Of Students In The Islamic Capital Market
Authors: Yustati Herlina , Junaidi Heri , Asnaini Asnaini
Published: March 2024

The purpose of this study was to determine the level of Islamic financial literacy and Islamic financial inclusion of students in Bengkulu Province, especially in Islamic capital market financial institutions. research methods with a quantitative approach survey method and data obtained through questionnaires given to 258 students in Bengkulu province who have a Sharia Investment Gallery. the results showed that the majority of Islamic financial literacy levels were at a moderate level (49%), as well as the slamic financial inclus level at a moderate level (45%).
Analysis Of Factors Affecting Provincial Minimum Wages In Indonesia
Authors: Simanjuntak Richardo , Yefriza Yefriza
Published: March 2024

The aim of this study is to analyze the factors that affect the minimum wage across different provinces in Indonesia. The study examines secondary data from Indonesia's Central Statistics Agency for the period 2018-2022, encompassing 34 provinces. The dependent variable in this study is the minimum wage of each province, while the independent variables used in this study are the need for a decent living, inflation, gross domestic product, and consumer price index. The data analysis method applied is panel data regression analysis with a random effect model. The research findings indicate that a higher standard of living, an increase in gross domestic product, and a rise in the consumer price index have a positive and significant effect on the minimum wage of each province. However, inflation does not appear to have a significant impact on the minimum wage of each province.