bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence for Pleistocene periglaciation in the lowlands of central Argentina (36–39°S)
Authors: Vogt Théa
Published: August 2022

Pleistocene permafrost has been recognized in the lowlands of extra-Andean Argentina from Tierra del Fuego to the Rio Negro valley at 40°S, and to the Sierras Australes at 38°S. Features that could have formed only by cryogenic activity at elevations between 230–400 m above sea level in surficial deposits and in the bedrock beneath are described here as far north as 36°S. These features are not as pronounced as they are farther south because most of central Argentina was a cold desert during the glacial episodes, and therefore little ice formed. Calcareous dust, formerly considered as pedogenic and now known to be glaciogenic, is closely associated with these features. Secondary precipitates, such as lamellar crystals of calcite and gypsum, and other microscopic features like those observed in perpetually frozen ground also confirm that this region experienced permafrost at some time. These new findings mean that the area affected by periglaciation is much larger than previously thought and expanded more than 200 km farther to the north. Stratigraphic evidence and geomorphological features place both deposits and cryogenic features within them as early–middle Pleistocene age.
A multimethod approach to the genesis of Menga, a World Heritage megalith
Authors: García Sanjuán Leonardo , Medialdea Alicia , Balsera Nieto Verónica , Athanassas Constantin , Pike Alistair , Standish Christopher D. , Dias Maria Isabel , Rodrigues Ana Luisa , Clavero Toledo José Luis , Wheatley David W. , Cintas-Peña Marta
Published: August 2022

The scientific study of Neolithic monuments holds fundamental keys to the analysis of early social complexity. This is often impeded by the challenges involved in understanding their temporality and, particularly, their initial construction dates. This problem is most severe in monuments that were not predominantly used for burial and went on to have long biographies in which activity in later periods obliterated the material record of the earliest phases. That was certainly the case of the Menga dolmen, part of the Antequera World Heritage site (Málaga, Spain), and one of the most remarkable megaliths in Europe, for which, after nearly 200 years of explorations and research, no firm chronology existed. The research presented in this paper shows how this problem was tackled through a multimethod, scientific, and geoarchaeological approach. The analysis of 29 fresh numerical ages, including radiocarbon determinations as well as optically stimulated luminescence, thermoluminescence, and uranium-thorium dates, led to the successful establishment of Menga's construction date and the subsequent contextualization of the monument within the social and cultural background it arose in. Placing the dolmen in the context of its time of “birth” introduces entirely new possibilities for its interpretation, both in terms of local and supralocal social and cultural processes.
Les termes transplantés : une approche réflexive de la philosophie en chinois moderne
Authors: Zhou Xiyin
Published: August 2022

Après la dispute soutenue à partir des années 1990 sur la question de savoir s'il y a une philosophie chinoise, plusieurs intellectuels chinois, y compris et surtout des philosophes, ont commencé, depuis une dizaine d'années, à se réunir autour d'une problématique plus concrète : « une philosophie en langue chinoise est-elle possible ? » ou « comment raisonner en chinois moderne ? » Parmi de nombreux sujets, celui des « termes transplantés » initié par Chen Jiaying (1952-) a attiré l'attention générale. Cet article compte, en s'appuyant sur son travail, introduire et approfondir ce problème en tant que défi particulier pour la pratique philosophique en chinois.
The Peaceful Origins of North Korea's Nuclear Programme in the Cold War Period, 1945–1965
Authors: Woo Donghyun
Published: August 2022

Was Kim Il-sung's desire to have nuclear weapons the sole reason for North Korea's quest for nuclear power? The answer, I argue, is highly unlikely given that extensive economic considerations played the most fundamental role in North Korea's pursuit of atomic energy from 1945 to 1965. With original, creative research on previously unexamined North Korean publications and Soviet archival materials, I demonstrate how the ‘peaceful’ impetus steered North Korea's early nuclear enterprises in the Cold War period. While previous studies draw only upon circumstantial evidence to argue that North Korea's going nuclear was predestined due to its security concerns, this article revises this teleological assumption by reconstructing historical contexts wherein the two driving factors that formed early North Korea's nuclear programme were mostly emulating how the Soviets harnessed nuclear power for economic gain, and aversion to the Americans’ use of nuclear power for atomic weapons to a lesser degree. That is, North Korea, like other countries in what later would be termed the Global South, sought to master nuclear technology for industrial ends in the first place, which turned out to be economically burdensome to continue, long before September 1965 when its first research reactor went online.
How Do Board Reforms Affect Debt Financing Costs Around the World?
Authors: (Zhao) Chiu Hui , Lin Chen , Wei Lai
Published: August 2022

In this study, we examine the effect of worldwide board reforms on the cost of debt financing. We document an increase of loan spread after a country initiates the reform. The increase is larger among firms that are more exposed to shareholder–debtholder conflicts. The results suggest that board reforms empower shareholders at the cost of debtholders. However, we also find that, while the reform component related to board independence leads to the increase in the cost of debt, the component related to audit committee independence helps decrease the cost.
Global epidemiology and molecular biology of Taenia multiceps: a comparative meta-analysis and in silico analysis study
Authors: Abbas Ibrahim , El-Alfy El-Sayed , Saleh Somaya , Tamponi Claudia , Varcasia Antonio
Published: August 2022

In the present study, all published data on the epidemiology and molecular characters of Taenia multiceps were systematically collected from relevant databases (e.g. PubMed, Scopus, National Center for Biotechnology Information), and combined in various statistical and genetic analyses as a contribution to a better understanding of the epidemiology of this ubiquitous taeniid worldwide. While 5.8% of the key hosts (dogs) from various countries had T. multiceps, grey wolves displayed the highest prevalence (21.6%) among the definitive hosts. Small ruminants are the main intermediate hosts and carry the coenuri in various locations, but most commonly in the central nervous system (CNS). Cerebral coenuri were confirmed in 53% of sheep exhibiting neurological symptoms, and infected animals often had only a single coenurus in the brain. Sheep had a higher prevalence (8.8%) of CNS coenuri than goats (5.8%); however, extra-CNS coenuri were detected more frequently in goats than in sheep. In either case, the difference between sheep and goats was statistically insignificant. Analysis of 233 partial cytochrome oxidase subunit I nucleotide sections for T. multiceps revealed high haplotype and low nucleotide diversities. Fifty-one haplotypes were detected circulating in 6 geographic populations. China, Iran and Turkey had 2 major haplotypes, whereas Italy and Egypt shared 3. Haplotypes from Greece circulate worldwide, and displayed similar gene flow values when compared with the other populations. There were no distinct patterns for haplotype distribution in relation to the infected hosts or coenuri locations. The existence of genetic variants in T. multiceps was highlighted, but needs further studies.
Resolving heterogeneity in depression using individualized structural covariance network analysis
Authors: Han Shaoqiang , Zheng Ruiping , Li Shuying , Zhou Bingqian , Jiang Yu , Fang Keke , Wei Yarui , Pang Jianyue , Li Hengfen , Zhang Yong , Chen Yuan , Cheng Jingliang
Published: August 2022

Background

Elucidating individual aberrance is a critical first step toward precision medicine for heterogeneous disorders such as depression. The neuropathology of depression is related to abnormal inter-regional structural covariance indicating a brain maturational disruption. However, most studies focus on group-level structural covariance aberrance and ignore the interindividual heterogeneity. For that reason, we aimed to identify individualized structural covariance aberrance with the help of individualized differential structural covariance network (IDSCN) analysis.

Methods

T1-weighted anatomical images of 195 first-episode untreated patients with depression and matched healthy controls (n = 78) were acquired. We obtained IDSCN for each patient and identified subtypes of depression based on shared differential edges.

Results

As a result, patients with depression demonstrated tremendous heterogeneity in the distribution of differential structural covariance edges. Despite this heterogeneity, altered edges within subcortical-cerebellum network were often shared by most of the patients. Two robust neuroanatomical subtypes were identified. Specifically, patients in subtype 1 often shared decreased motor network-related edges. Patients in subtype 2 often shared decreased subcortical-cerebellum network-related edges. Functional annotation further revealed that differential edges in subtype 2 were mainly implicated in reward/motivation-related functional terms.

Conclusions

In conclusion, we investigated individualized differential structural covariance and identified that decreased edges within subcortical-cerebellum network are often shared by patients with depression. The identified two subtypes provide new insights into taxonomy and facilitate potential clues to precision diagnosis and treatment of depression.
Optimal singular dividend control with capital injection and affine penalty payment at ruin
Authors: Xu Ran
Published: August 2022

In this paper, we extend the optimal dividend and capital injection problem with affine penalty at ruin in (Xu, R. & Woo, J.K. (2020). Insurance: Mathematics and Economics 92: 1–16) to the case with singular dividend payments. The asymptotic relationships between our value function to the one with bounded dividend density are studied, which also help to verify that our value function is a viscosity solution to the associated Hamilton–Jacob–Bellman Quasi-Variational Inequality (HJBQVI). We also show that the value function is the smallest viscosity supersolution within certain functional class. A modified comparison principle is proved to guarantee the uniqueness of the value function as the viscosity solution within the same functional class. Finally, a band-type dividend and capital injection strategy is constructed based on four crucial sets; and the optimality of such band-type strategy is proved by using fixed point argument. Numerical examples of the optimal band-type strategies are provided at the end when the claim size follows exponential and gamma distribution, respectively.
Almost first-order stochastic dominance by distorted expectations
Authors: Yang Jianping , Zhou Tian , Zhuang Weiwei
Published: August 2022

Almost stochastic dominance has been receiving a great amount of attention in the financial and economic literatures. In this paper, we characterize the properties of almost first-order stochastic dominance (AFSD) via distorted expectations and investigate the conditions under which AFSD is preserved under a distortion transform. The main results are also applied to establish stochastic comparisons of order statistics and receiver operating characteristic curves via AFSD.
China's Water Governmentality and the Shaping of Hydrosocial Territories in the Lancang-Mekong Region
Authors: Wang Raymond Yu , Liu Xiaofeng , Zhang Wenya
Published: August 2022

This paper examines China's water governmentality in advancing the Lancang-Mekong Cooperation (LMC). It attends to how discourses, used as a political instrument, are framed, justified and contested in the reshaping of international hydrosocial territories. China's official and popular discourses present the LMC as promoting multilateral politics, economic benefits and social integration, while they obscure polarizing politics, external interventions and regional conflicts. Using strategies of positive publicity first, top-down communication and mutual empathy creation, these discourses aim to deflect attention away from controversies and geopolitics in the region to construct governable hydrosocial territories. However, in a transnational context where the Chinese state cannot unilaterally control geographical imaginaries, alternative discourses depict China as a “hydro-hegemon” that poses threats to downstream countries. The discursive dichotomy reflects multiple ontologies of water and power struggles in international river governance, bringing regional stability and sustainable development into question.
A multi-site survey of providers on the management of heart failure with dilated cardiomyopathy in children
Authors: Law Yuk M. , Jacobs-Files Elizabeth , Auerbach Scott , Lal Ashwin K. , Richmond Marc , Schumacher Kurt , Singh Rakesh , Desai Arti
Published: August 2022

We conducted a scientific survey of paediatric practitioners who manage heart failure with dilated cardiomyopathy in children. The survey covered management from diagnosis to treatment to monitoring, totalling 63 questions. There were 54 respondents from 40 institutions and 3 countries. There were diverse selections of management options by the respondents in general, but also unanimity in some management options. Variation in practice is likely due to the relative paucity of scientific data in this field and lack of strong evidence-based recommendations from guidelines, which presents an opportunity for future research and quality improvement efforts as the evidence base continues to grow.
Early metrical and lexicographical evidence for functional stress-shifts
Authors: MINKOVA DONKA , ZHOU Z.L.
Published: August 2022

Only three English diatones,outlaw,rebel,record, out of the current 235-item list in Hotta (2015), are on record prior to the seventeenth century; the latest record of diatonicoutlawis 1786 (Sherman 1975: 63). Whether this type of functional prosodic contrast was inherited or innovative is controversial. We revisit the Old English metrical evidence for functional stress-shifting and present new attestations of verb–noun pairs in Middle English verse in an effort to establish if the limited inherited stress-shifting model survives, and, if so, whether or how it accommodates the incoming loan vocabulary. The additional verse attestations support the idea of continuity, yet the scarcity of data falls short of statistical verifiability. A search into detailed lexicographical information for 1200–1550 reinforces the hypothesis of continuity by documenting the differential patterns of borrowing of nouns and verbs, prefixed and unprefixed. Taken together, these two sources endorse a proposal that in its earliest stages functional stress-shifting was predicated on prefixation, and that the ongoing conflict between prefixal defooting andAlign-L(Root, PrWd) in ME is a necessary component of the diachronic account of English prosody.
The foreign language effect on motivational quotes
Authors: Braida Barbara , Rodríguez-Ferreiro Javier , Hernández Mireia
Published: August 2022

According to the “reduced emotionality hypothesis”, we are less emotionally driven when reasoning in a foreign language (FL) than in a native language (NL). We examined whether this foreign language effect (FLe) extends to the way we perceive motivational quotes (i.e., encouraging slogans conveying a profound and inspirational message): we expected FL participants to rate motivational quotes as less profound than NL participants. Strikingly, we observed the opposite: FL participants found motivational quotes more profound than NL participants, even after controlling for potential confounders (e.g., IQ, reasoning style). Both FL and NL participants gave similarly low profundity ratings to pseudo-profound bullshit sentences (i.e., meaningless sentences sounding profound), indicating that the message must be meaningful for the FLe to arise. We propose that, like space or time, language could promote psychological distance. This favours a focus on the background of a message to indicate profoundness.
Do party politics still matter? Examining the effect of parties, governments and government changes on the local tax rate in Sweden
Authors: Högström John , Lidén Gustav
Published: August 2022

According to partisan theory, variations in policy choices and outputs originate from the party composition of the government studied. In this study, we take a novel approach to address such assumptions by linking changes in municipal taxes with local government changes. We also add a baseline scenario in which we examine whether the composition of the local government affects tax levels. Drawing on a dataset that contains official Swedish statistics from 1994 to 2018, we find convincing support for the partisan effect. Tax levels are higher under left-wing rule, and more specifically, tax cuts particularly occur when left-wing governments are replaced by right-wing ones. These results do not vanish when controls are accounted for, while it can be particularly noticed that the condition of the municipal economy influences partisan ambitions. These findings thereby contradict prior theoretical assumptions that the local arena is free from ideological battles.
Exclusive humanitarianism: Policy recommendations for genuine inclusion of persons with disabilities in humanitarian action
Authors: Young Kirsten
Published: August 2022

The challenge faced by Somalia's newly established National Disability Agency (NDA), along with other emerging actors in the disability arena, is how to address the perception that disability is primarily a humanitarian issue in a country that not only is in conflict but also faces cyclical humanitarian crises. A further challenge for the NDA is how to ensure that the humanitarian architecture put in place facilitates non-discrimination, as well as the inclusion of and participation by persons with disabilities. While a typical humanitarian architecture can inadvertently reinforce an already stigmatizing charity or welfare approach towards persons with disabilities, Somalia's experience demonstrates that humanitarian actors can do a lot with leadership, a willingness to leave agency branding behind, and an active committed partner such as the NDA. Nevertheless, genuine inclusion in Somalia's overall State-building project needs also to be the remit of development, reconciliation and similar actors, with access to and participation of persons with disabilities guaranteed in their range of processes and frameworks.
Changes in Arctic Halocline Waters Along the East Siberian Slope and in the Makarov Basin From 2007 to 2020
Authors: Bertosio Cécilia , Provost Christine , Athanase Marylou , Sennéchael Nathalie , Garric Gilles , Lellouche Jean‐Michel , Kim Joo‐Hong , Cho Kyoung‐Ho , Park Taewook
Published: August 2022

The evolution of halocline waters in the Makarov Basin and along the East Siberian continental slope is examined by combining drifting platform observations, shipborne hydrographic data, and simulations from a global operational physical model from 2007 to 2020. From 2012 onwards, relatively shallow and cold Atlantic‐derived lower halocline waters, previously restricted to the Lomonosov Ridge area, progressed eastward along the East Siberian continental slope. Their eastward extent abruptly shifted from 155°E to 170°E in early 2012, stabilized at 170°E until the end of 2015, then gradually advanced to reach the western Chukchi Sea in 2017. Such eastward progression led to a strengthening of the associated boundary current and to the shedding of mesoscale eddies of cold Atlantic‐derived waters into the lower halocline of the Makarov Basin in September 2015 and near the East Siberian continental slope in November 2017. Additionally, active mixing between upwelled Atlantic Water and shelf water formed dense warm water supplying the Makarov Basin lower halocline. The increasing contribution from Atlantic‐derived waters into the lower halocline along the East Siberian continental slope and in the Makarov Basin led to a weakening of the halocline, which is characteristic of a new Arctic Ocean regime that started in the early 2000s in the Eurasian Basin. Our results suggest that this new Arctic regime may now extend toward the Amerasian Basin.
Modulating and Resetting Impacts of Different Volcanic Eruptions on North Atlantic SST Variations
Authors: Chen Kefan , Ning Liang , Liu Zhengyu , Liu Jian , Yan Mi , Sun Weiyi , Li Longhui , Shi Zhengguo
Published: August 2022

This study investigates the impact of volcanic eruption on the North Atlantic (NA) sea surface temperature (SST) during the last millennium based on both model simulations and reconstructions. Our focus is on the two types of relations between the states of SST and associated climate variables before and after the eruption: modulating and resetting. Here, modulating means that the posterior conditions depend on the initial SST and the volcano‐induced cooling is linearly superimposed on the initial SST phases, while resetting means that the posterior conditions are independent from the initial condition. Our analysis demonstrates that equatorial and northern volcanic eruptions larger than 30 Tg could reset NA SST, and there is a limitation of SST decrease after eruption, indicating the largest SST decrease does not exceed a certain value. While equatorial volcanic eruptions larger than 100 Tg and northern volcanic eruptions larger than 30 Tg can reset subsurface temperature changes. In contrast, even the largest volcanic eruption during the last millennium cannot reset the Atlantic Meridional Overturning Circulation.
Constraining Magma Reservoir Conditions by Integrating Thermodynamic Petrological Models and Bulk Resistivity From Magnetotellurics
Authors: Cordell Darcy , Naif Samer , Troch Juliana , Huber Christian
Published: August 2022

Magnetotelluric (MT) data image the bulk resistivity of the subsurface which can be used to infer magma reservoir conditions beneath volcanoes. The bulk resistivity of magma depends primarily on the melt volume fraction, temperature, and water content. These variables are coupled thermodynamically, yet mixing relations for bulk resistivity implicitly treat them as independent. Here, we use a parameterization of the rhyolite‐MELTS thermodynamic model to constrain relationships between melt fraction, temperature, dissolved water content and bulk resistivity for rhyolitic magmas. This method results in MT interpretations which are (a) thermodynamically consistent at near‐equilibrium conditions, (b) independent of temperature and water content estimates derived from erupted products, and (c) able to consider saturated melts containing a volatile (i.e., aqueous fluid) phase. The utility of the method is demonstrated with three case studies of silicic systems: Mono Basin, Newberry volcano and the Laguna del Maule Volcanic Field (LdMVF). The moderately conductive feature at Mono Basin can be explained by under‐saturated partial melt (6–15 vol%) at <775°C, indicating relatively stable magma storage conditions since the last eruption. However, a relatively resistive feature at Newberry Volcano requires lower temperatures (<750°C) than previous estimates, suggesting that the system has cooled since the last eruption. A conductive feature at the LdMVF cannot be explained by saturated or under‐saturated rhyolitic melt and requires additional conductive phases. These results demonstrate the potential of this new method to reduce uncertainty in MT interpretations and highlight the need for additional coupling strategies between petrology, geophysics, and thermo‐mechanical models to better understand magmatic systems.
Neglected Spatiotemporal Variations of Model Biases in Ensemble‐Based Climate Projections
Authors: Song Tangnyu , Huang Guohe , Wang Xiuquan
Published: August 2022

The Bayesian model averaging (BMA) method has been widely used for generating probabilistic climate projections. However, the averaging weights used in BMA can only reflect the spatially‐ and temporally‐averaged performance of each ensemble member, without the ability to address the spatiotemporal variations of model biases. This can lead to inevitable exaggeration or understatement of the contributions of individual members to the ensemble mean, thus reducing the robustness of the resulting probabilistic projections. Here we propose a new method to help address the neglected spatiotemporal variations of model biases. Through the proposed method, the BMA weights are used as prior distributions to drive the Bayesian discriminant analysis in order to generate refined weights for individual ensemble models according to their spatially‐ and temporally‐clustered performance. Through applying the proposed method to Canada, we demonstrate its effectiveness in generating robust probabilistic climate projections (e.g., the average R2 increases from 0.82 to 0.89).
Linking Distributed and Integrated Fiber‐Optic Sensing
Authors: Bowden Daniel C. , Fichtner Andreas , Nikas Thomas , Bogris Adonis , Simos Christos , Smolinski Krystyna , Koroni Maria , Lentas Konstantinos , Simos Iraklis , Melis Nikolaos S.
Published: August 2022

Distributed Acoustic Sensing (DAS) has become a popular method of observing seismic wavefields: backscattered pulses of light reveal strains or strain rates at any location along a fiber‐optic cable. In contrast, a few newer systems transmit light through a cable and collect integrated phase delays over the entire cable, such as the Microwave Frequency Fiber Interferometer (MFFI). These integrated systems can be deployed over significantly longer distances, may be used in conjunction with live telecommunications, and can be significantly cheaper. However, they provide only a single time series representing strain over the entire length of the fiber. This work discusses theoretically how a distributed and integrated system can be quantitatively compared, and we note that the sensitivity depends strongly on points of curvature. Importantly, this work presents the first results of a quantitative, head‐to‐head comparison of a DAS and the integrated MFFI system using pre‐existing telecommunications fibers in Athens, Greece.
Projected Changes of Surface Winds Over the Antarctic Continental Margin
Authors: Neme Julia , England Matthew H. , McC. Hogg Andrew
Published: August 2022

Surface winds around the Antarctic continent control coupled ocean‐ice processes that influence the climate system, including bottom water production, heat transport onto the continental shelf and sea ice coverage. However, few studies have examined projected changes in these winds, even though it would aid in the interpretation and understanding of the ocean's response to climate change. Using Coupled Model Intercomparison Project Phase 6 and reanalysis data, we show a significant reduction in the near‐Antarctic surface winds throughout the historical period that continues until the end of the twenty‐first century, amounting to 23% and 7% for the easterly and southerly wind components respectively under the high emission scenario. The most intense weakening happens during the summer season. We find that the weakening is coherent with the trend toward a positive Southern Annular Mode and a reduction of the pole‐to‐coast meridional pressure gradient, which we term Antarctic Annular Index.
Increasing Trends in Oceanic Surface Poleward Eddy Heat Flux Observed Over the Past Three Decades
Authors: Guo Yiming , Bachman Scott , Bryan Frank , Bishop Stuart
Published: August 2022

Mesoscale processes make the largest contribution to ocean variability and are significant agents in ocean heat transport. In this investigation, we provide evidence based on satellite observations for an increasing trend in surface transient eddy heat flux (EHF) over the period 1993–2020. The enhanced EHF is particularly prominent in western boundary currents and their extensions at mid‐latitudes, with increases of 20%–40% per decade. Additionally, we decompose the EHF trend into contributions from velocity variance, temperature variance and a coherence parameter using a Cauchy–Schwarz inequality. We find that each contributes to the spatial pattern of the trend in EHF, with the contribution from enhanced temperature variance dominating the global zonal mean EHF trend over the past few decades.
Do we get better outcomes from early treatment of Class III discrepancies?
Authors: DiBiase Andrew T. , Seehra Jadbinder , Papageorgiou Spyridon N. , Cobourne Martyn T.
Published: August 2022

Early orthodontic treatment in the mixed dentition aims to simplify definitive treatment in the permanent dentition. In Class III cases, this can be an effective strategy for the management of a local anterior crossbite, using either a removable or simple fixed appliance. For more significant Class III malocclusions, the decision to intervene early is a more difficult one. Traditionally, orthodontists in the UK have been reluctant to embark on early treatment in the presence of a skeletal Class III relationship but there is now some evidence that in selected cases, the use of protraction headgear can be a successful method of avoiding the need for later surgery. Although growth prediction in Class III cases is notoriously difficult, in the presence of maxillary retrognathia, the general dental practitioner should consider early referral of Class III cases to a specialist orthodontist.
Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a
Authors: Clusmann Jan , Franco Klaus-Daniel Cortés , Suárez David Alejandro Corredor , Katona Istvan , Minguez Maria Girbes , Boersch Nina , Pissas Karolos-Philippos , Vanek Jakob , Tian Yuemin , Gründer Stefan
Published: August 2022

Eliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It has been reported that prolonged activation of acid-sensing ion channel 1a (ASIC1a) induces necroptosis in mouse neurons. Glioblastoma stem cells (GSCs) also express functional ASIC1a, but whether prolonged activation of ASIC1a induces necroptosis in GSCs is unknown. Here we used a tumorsphere formation assay to show that slight acidosis (pH 6.6) induces necrotic cell death in a manner that was sensitive to the necroptosis inhibitor Nec-1 and to the ASIC1a antagonist PcTx1. In addition, genetic knockout of ASIC1a rendered GSCs resistant to acid-induced reduction in tumorsphere formation, while the ASIC1 agonist MitTx1 reduced tumorsphere formation also at neutral pH. Finally, a 20 amino acid fragment of the ASIC1 C-terminus, thought to interact with the necroptosis kinase RIPK1, was sufficient to reduce the formation of tumorspheres. Meanwhile, the genetic knockout of MLKL, the executive protein in the necroptosis cascade, did not prevent a reduction in tumor sphere formation, suggesting that ASIC1a induced an alternative cell death pathway. These findings demonstrate that ASIC1a is a death receptor on GSCs that induces cell death during prolonged acidosis. We propose that this pathway shapes the evolution of a tumor in its acidic microenvironment and that pharmacological activation of ASIC1a might be a potential new strategy in tumor therapy.
Chromatin-Associated Molecular Patterns (CAMPs) in sepsis
Authors: Nofi Colleen P. , Wang Ping , Aziz Monowar
Published: August 2022

Several molecular patterns have been identified that recognize pattern recognition receptors. Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are commonly used terminologies to classify molecules originating from pathogen and endogenous molecules, respectively, to heighten the immune response in sepsis. Herein, we focus on a subgroup of endogenous molecules that may be detected as foreign and similarly trigger immune signaling pathways. These chromatin-associated molecules, i.e., chromatin containing nuclear DNA and histones, extracellular RNA, mitochondrial DNA, telomeric repeat-containing RNA, DNA- or RNA-binding proteins, and extracellular traps, may be newly classified as chromatin-associated molecular patterns (CAMPs). Herein, we review the release of CAMPs from cells, their mechanism of action and downstream immune signaling pathways, and targeted therapeutic approaches to mitigate inflammation and tissue injury in inflammation and sepsis.
Deterministic magnetic moment rotation in antiferromagnetic material by piezoelectric strain modulation
Authors: Liu Mengli , Ma Chengxin , Du Wei , Su Hua , Zhang Huaiwu , Liu Bo , Meng Hao , Tang Xiaoli
Published: August 2022

Antiferromagnetic (AFM) spintronic devices play a vital role in the development of novel spintronic devices due to their attractive features. Herein, the interfacial state manipulation of the AFM IrMn material is investigated by combining a ferroelectric single crystal Pb(Mg1/3Nb2/3)0.7Ti0.3O3 (PMN-PT) with an electric field (E-field)-controlled magnetic moment arrangement of the IrMn film. A PMN-PT/Cu/IrMn/NiFe heterostructure is chosen to confirm the deterministic manipulation of AFM interfacial states and its angle of magnetic moment rotation. The appropriate thickness of the Cu layer is selected to disrupt the strain-mediated magnetoelectric coupling between the NiFe layer and PMN-PT substrate. The NiFe film reference layer can reflect the variation in AFM interfacial states via the exchange bias. When the E-field is applied, an in-plane piezoelectric strain is produced. If IrMn responds to the strain, its magnetic moment rotates from [001] to [1−10] depending on the crystal orientation of PMN-PT. Based on the experimental results and theoretical analyses, a rotation in the magnetic moment of the IrMn layer by ~20° is confirmed. This work provides convincing evidence for the manipulation of E-field-controlled AFM interfacial states and describes a reliable method for achieving the rotation angle of AFM moments, which can help to accelerate the development of AFM spintronic devices.
Intelligent control of nanoparticle synthesis on microfluidic chips with machine learning
Authors: Chen Xueye , Lv Honglin
Published: August 2022

Nanoparticles play irreplaceable roles in optoelectronic sensing, medical therapy, material science, and chemistry due to their unique properties. There are many synthetic pathways used for the preparation of nanoparticles, and different synthetic pathways can produce nanoparticles with different properties. Therefore, it is crucial to control the properties of nanoparticles precisely to impart the desired functions. In general, the properties of nanoparticles are influenced by their sizes and morphologies. Current technology for the preparation of nanoparticles on microfluidic chips requires repeated experimental debugging and significant resources to synthesize nanoparticles with precisely the desired properties. Machine learning-assisted synthesis of nanoparticles is a sensible choice for addressing this challenge. In this paper, we review many recent studies on syntheses of nanoparticles assisted by machine learning. Moreover, we describe the working steps of machine learning, the main algorithms, and the main ways to obtain datasets. Finally, we discuss the current problems of this research and provide an outlook.
Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms
Authors: Boudehen Yves-Marie , Faucher Marion , Maréchal Xavier , Miras Roger , Rech Jérôme , Rombouts Yoann , Sénèque Olivier , Wallat Maximilian , Demange Pascal , Bouet Jean-Yves , Saurel Olivier , Catty Patrice , Gutierrez Claude , Neyrolles Olivier
Published: August 2022

The human pathogen Mycobacterium tuberculosis requires a P1B-ATPase metal exporter, CtpC (Rv3270), for resistance to zinc poisoning. Here, we show that zinc resistance also depends on a chaperone-like protein, PacL1 (Rv3269). PacL1 contains a transmembrane domain, a cytoplasmic region with glutamine/alanine repeats and a C-terminal metal-binding motif (MBM). PacL1 binds Zn2+, but the MBM is required only at high zinc concentrations. PacL1 co-localizes with CtpC in dynamic foci in the mycobacterial plasma membrane, and the two proteins form high molecular weight complexes. Foci formation does not require flotillin nor the PacL1 MBM. However, deletion of the PacL1 Glu/Ala repeats leads to loss of CtpC and sensitivity to zinc. Genes pacL1 and ctpC appear to be in the same operon, and homologous gene pairs are found in the genomes of other bacteria. Furthermore, PacL1 colocalizes and functions redundantly with other PacL orthologs in M. tuberculosis. Overall, our results indicate that PacL proteins may act as scaffolds that assemble P-ATPase-containing metal efflux platforms mediating bacterial resistance to metal poisoning.
Practical continuous-variable quantum key distribution with composable security
Authors: Jain Nitin , Chin Hou-Man , Mani Hossein , Lupo Cosmo , Nikolic Dino Solar , Kordts Arne , Pirandola Stefano , Pedersen Thomas Brochmann , Kolb Matthias , Ömer Bernhard , Pacher Christoph , Gehring Tobias , Andersen Ulrik L.
Published: August 2022

A quantum key distribution (QKD) system must fulfill the requirement of universal composability to ensure that any cryptographic application (using the QKD system) is also secure. Furthermore, the theoretical proof responsible for security analysis and key generation should cater to the number N of the distributed quantum states being finite in practice. Continuous-variable (CV) QKD based on coherent states, despite being a suitable candidate for integration in the telecom infrastructure, has so far been unable to demonstrate composability as existing proofs require a rather large N for successful key generation. Here we report a Gaussian-modulated coherent state CVQKD system that is able to overcome these challenges and can generate composable keys secure against collective attacks with N ≈ 2 × 108 coherent states. With this advance, possible due to improvements to the security proof and a fast, yet low-noise and highly stable system operation, CVQKD implementations take a significant step towards their discrete-variable counterparts in practicality, performance, and security.
Overall negative trends for snow cover extent and duration in global mountain regions over 1982–2020
Authors: Notarnicola C.
Published: August 2022

Notwithstanding the large availability of data and models, a consistent picture of the snow cover extent and duration changes in global mountain areas is lacking for long-term trends. Here, model data and satellite images are combined by using Artificial Neural Networks to generate a consistent time series from 1982 to 2020 over global mountain areas. The analysis of the harmonized time series over 38 years indicates an overall negative trend of − 3.6% ± 2.7% for yearly snow cover extent and of − 15.1 days ± 11.6 days for snow cover duration. The most affected season by negative trends is winter with an average reduction in snow cover extent of − 11.5% ± 6.9%, and the most affected season by positive changes is spring with an average increase of 10% ± 5.9%, the latter mainly located in High Mountain Asia. The results indicated a shift in the snow regime located between the 80 s and 90 s of the previous century, where the period from 1982 to 1999 is characterized by a higher number of areas with significant changes and a higher rate of changes with respect to the period 2000–2020. This quantification can lead to a more accurate evaluation of the impact on water resources for mountainous communities.
Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care
Authors: George Benu , Bhatia Nitish , Kumar Abhitinder , A. Gnanamani , R. Thilagam , S. K. Shanuja , Vadakkadath Meethal Kannan , T. M. Shiji , T. V. Suchithra
Published: August 2022

Proper burn wound management considers patient’s compliance and provides an environment to accelerate wound closure. Sticky hydrogels are conducive to wound management. They can act as a preventive infection patch with controlled drug delivery and diverse surface adherence. A hypothesis-driven investigation explores a bioinspired polydopamine property in a gelatin-based hydrogel (GbH) where polyvinyl alcohol and starch function as hydrogel backbone. The GbH displayed promising physical properties with O–H group rich surface. The GbH was sticky onto dry surfaces (glass, plastic and aluminium) and wet surfaces (pork and chicken). The GbH demonstrated mathematical kinetics for a transdermal formulation, and the in vitro and in vivo toxicity of the GbH on test models confirmed the models’ healthy growth and biocompatibility. The quercetin-loaded GbH showed 45–50% wound contraction on day 4 for second-degree burn wounds in rat models that were equivalent to the silver sulfadiazine treatment group. The estimates for tensile strength, biochemicals, connective tissue markers and NF-κB were restored on day 21 in the GbH treated healed wounds to imitate the normal level of the skin. The bioinspired GbH promotes efficient wound healing of second-degree burn wounds in rat models, indicating its pre-clinical applicability.
High-resolution surface water dynamics in Earth’s small and medium-sized reservoirs
Authors: Donchyts Gennadii , Winsemius Hessel , Baart Fedor , Dahm Ruben , Schellekens Jaap , Gorelick Noel , Iceland Charles , Schmeier Susanne
Published: August 2022

Small and medium-sized reservoirs play an important role in water systems that need to cope with climate variability and various other man-made and natural challenges. Although reservoirs and dams are criticized for their negative social and environmental impacts by reducing natural flow variability and obstructing river connections, they are also recognized as important for social and economic development and climate change adaptation. Multiple studies map large dams and analyze the dynamics of water stored in the reservoirs behind these dams, but very few studies focus on small and medium-sized reservoirs on a global scale. In this research, we use multi-annual multi-sensor satellite data, combined with cloud analytics, to monitor the state of small (10–100 ha) to medium-sized (> 100 ha, excluding 479 large ones) artificial water reservoirs globally for the first time. These reservoirs are of crucial importance to the well-being of many societies, but regular monitoring records of their water dynamics are mostly missing. We combine the results of multiple studies to identify 71,208 small to medium-sized reservoirs, followed by reconstructing surface water area changes from satellite data using a novel method introduced in this study. The dataset is validated using 768 daily in-situ water level and storage measurements (r2 > 0.7 for 67% of the reservoirs used for the validation) demonstrating that the surface water area dynamics can be used as a proxy for water storage dynamics in many cases. Our analysis shows that for small reservoirs, the inter-annual and intra-annual variability is much higher than for medium-sized reservoirs worldwide. This implies that the communities reliant on small reservoirs are more vulnerable to climate extremes, both short-term (within seasons) and longer-term (across seasons). Our findings show that the long-term inter-annual and intra-annual changes in these reservoirs are not equally distributed geographically. Through several cases, we demonstrate that this technology can help monitor water scarcity conditions and emerging food insecurity, and facilitate transboundary cooperation. It has the potential to provide operational information on conditions in ungauged or upstream riparian countries that do not share such data with neighboring countries. This may help to create a more level playing field in water resource information globally.
Synthesis, characterization and photocatalytic properties of nanostructured lanthanide doped β-NaYF4/TiO2 composite films
Authors: Pennisi Fabiana M. , Pellegrino Anna L. , Licciardello Nadia , Mezzalira Claudia , Sgarzi Massimo , Speghini Adolfo , Malandrino Graziella , Cuniberti Gianaurelio
Published: August 2022

The photocatalytic approach is known to be one of the most promising advanced oxidation processes for the tertiary treatment of polluted water. In this paper, β-NaYF4/TiO2 composite films have been synthetized through a novel sol–gel/spin-coating approach using a mixture of β-diketonate complexes of Na and Y, and Yb3+, Tm3+, Gd3+, Eu3+ as doping ions, together with the TiO2 P25 nanoparticles. The herein pioneering approach represents an easy, straightforward and industrially appealing method for the fabrication of doped β-NaYF4/TiO2 composites. The effect of the doped β-NaYF4 phase on the photocatalytic activity of TiO2 for the degradation of methylene blue (MB) has been deeply investigated. In particular, the upconverting TiO2/β-NaYF4: 20%Yb, 2% Gd, x% Tm (x = 0.5 and 1%) and the downshifting TiO2/β-NaYF4: 10% Eu composite films have been tested on MB degradation both under UV and visible light irradiation. An improvement up to 42.4% in the degradation of MB has been observed for the TiO2/β-NaYF4: 10% Eu system after 240 min of UV irradiation.
Enhanced thermal effectiveness for electroosmosis modulated peristaltic flow of modified hybrid nanofluid with chemical reactions
Authors: Hussain Arafat , Wang Jun , Akbar Yasir , Shah Riaz
Published: August 2022

In this analysis, the thermal and flow properties of modified hybrid nanofluids (MNFs) have been investigated under the effects of electroosmosis and homogeneous-heterogeneous chemical reactions. Three types of nanoparticles of Cu, CuO, and Al2O3 are utilized to monitor the performance of the MNFs with water as a working liquid. The determination of the heating phenomenon is explored by incorporating the effects of NPs shape, temperature reliant viscosity, Joule heating, heat generation/absorption and viscous dissipation. In this exploration, equal diffusion factors for the auto catalyst and reactants are assumed. The model formulation contains a highly non-linear PDE system, which is converted to ODEs under physical assumptions with lubrication and Debye–Huckel. The solution treatment involves the Homotopy perturbation method for solving the governing differential equations is used. A major outcome discloses that an addition in heterogeneous reaction parameter aids in enhancing the concentration profile. In a result, the temperature curve decreases at increasing volume fraction of the NPs. Modified hybrid NFs have higher heat transfer rate as compared to base H20, or ordinary Al2O3–H20 and hybrid Cu + Al2O3–H20 NFs. Pressure gradient decreases by improving electroosmotic parameter. Further a comparison between analytically (HPM) and numerical results (NDSolve) show that both results are in good agreement.
The diagnostic value of has_circ_0006423 in non-small cell lung cancer and its role as a tumor suppressor gene that sponges miR-492
Authors: Zhu Linwen , Sun Lebo , Xu Guodong , Song Jie , Hu Bingchuan , Fang Zhongjie , Dan Yanggang , Li Ni , Shao Guofeng
Published: August 2022

The diagnosis and treatment of non-small cell lung cancer (NSCLC) are not ideal. We identified NSCLC-related has_circ_0006423 in database. qRT-PCR was used to measure expression levels of hsa_circ_0006423 and miR-492 in the plasma and tissue samples, and 3 NSCLC cell lines, respectively. We analyzed the relationship between expression levels of hsa_circ_0006423 and clinicopathological factors and miR-492 expression in plasma and tissue samples. Assess the diagnostic value of hsa_circ_0006423 and miR-492 in NSCLC. Cell function vitro experiment to explore the effect of has_circ_0006423 on NSCLC. We found has_circ_0006423 is lower expressed in NSCLC and miR-492 is opposite, has_circ_0006423 and miR-492 has diagnostic value in NSCLC. In A549 and NCI-H1299 cells, hsa_circ_0006423 inhibited the proliferation, migration, and invasion of NSCLC cells by sponging miR-492 and accelerating NSCLC cell apoptosis. This effect may be due to the combination of has_circ_0006423 and miR-492 affecting the progression of NSCLC.