bluuebunny/crossref_metadata_2025 huggingface dataset:
The positive solitude scale (PS): psychometric properties among Chinese older
Authors: Fan Zhiguang , Cai Huilin , Shi Xiaoli , Yu Ningyao , Chen Lei
Published: August 2024

Background

Positive solitude, taken as a meaningful activity, contributes to the improvement of health, well-being, and quality of life of older adults. The purpose of this study was to examine the reliability and validity of the Positive Solitude Scale (PS) among Chinese older to provide a reference for related research.

Methods

A convenience sample of 608 older people from 10 provinces in China was used to conduct the survey.

Results

The Chinese version of the PS consisted of 9 items with a unidimensional structure, which could explain 60.91% of the variance. The factor loadings of each item ranged from 0.67 to 0.82, and the communality ranged from 0.44 to 0.68. The confirmatory factor analysis showed good model fit (χ2/df = 2.771, RMSEA = 0.076, CFI = 0.972, IFI = 0.972, TLI = 0.959, PNFI = 0.665, PCFI = 0.675). It was found from the criterion-related validity test that PS scores were significantly and positively correlated with Satisfaction With Life Scale (SWLS), Autonomy, Competence, and Relatedness scores (r = 0.45 to 0.44); PS scores were significantly and negatively correlated with Short-Form UCLA Loneliness Scale (ULS-6), Kessler Psychological Distress Scale (K10), Ego Depletion Scale (EDS), and Acceptance and Action Questionnaire-2nd Edition (AAQ-II) (r = -0.27 to -0.36). The Cronbach’s α coefficient value for the scale was 0.917; the split-half reliability coefficient value was 0.928. In addition, the PS showed cross-gender consistency.

Conclusions

The PS presented favorable psychometric characteristics in older people, which can be used as a valid tool for assessing older people’s positive solitude.
Workload disparities and their role in the health of migrants and natives in Germany
Authors: Ingwersen Kai , Thomsen Stephan L.
Published: August 2024

Background

This study explores the health status differences between migrants and native Germans, focusing on potential disparities in their workloads. Physical and mental workloads can negatively impact individual health. Since various occupations come with distinct health-related patterns, occupational selection may contribute to systematic health disparities among socio-economic groups. Given the generally poorer health of migrants, they might experience systematic workload differences overall.

Methods

We suggest a conceptual framework for the empirical analysis based on the theory of health as a durable good with health consumption and health investment as key parameters. We quantify the role of work tasks, job requirements and working conditions on individual health based on detailed information from the BIBB/BAuA labour force survey 2012 and 2018.

Results

The empirical results reveal that migrants, i.e. foreigners and German citizens with a migration background, have a higher perception of workload and related health afflictions within the same occupation. Native Germans, on the other hand, experience a higher burden by high job requirements, both physically and mentally. The findings imply heterogeneous health impacts of work for migrants and native Germans due to differences in health consumption.

Conclusions

The analysis shows that migrants report worse health than natives, with stronger negative effects of work-related conditions on their health, both physically and mentally. Women, in general, report poorer health conditions than men. The findings emphasize the importance of promoting human capital to reduce economic and health disparities, though caution is advised regarding affirmative actions for migrants; further research is needed to understand the underlying mechanisms and address these issues effectively.
Metabolic responses to albumin deficiency differ distinctly between partial and full ablation of albumin expression in mice
Authors: Abdollahi Afsoun , Szramowski Mirandia , Tomoo Keigo , Henderson Gregory C.
Published: August 2024

It had been observed that homozygous albumin knockout mice (Alb−/−) exhibit low plasma free fatty acid (FFA) concentration and improved blood glucose regulation. However, it was not yet known to what extent heterozygous albumin knockout (Alb+/−) mice would display a similar phenotype. Alb−/−, Alb+/−, and wild-type (WT) female mice were studied on a low-fat diet (LFD) or high-fat diet (HFD). On both diets, decreased plasma FFA concentration, and improved glucose tolerance test were observed in Alb−/−, but not in Alb+/−, compared to WT. Plasma adiponectin concentration showed greater elevation in Alb−/− than Alb+/−. Consistent with that, adiponectin gene expression was significantly higher in Alb−/− mice than in Alb+/− and WT mice. A dose-dependent response was observed for hepatic Acadl gene expression showing higher Acadl gene expression in Alb−/− mice than in Alb+/− and WT mice. In conclusion, although female Alb+/− mice exhibited some slight differences from WT mice (e.g., increased plasma adiponectin and hepatic Acadl gene expression), Alb+/− mice did not exhibit improved glucoregulation in comparison to WT mice, indicating that a minor suppression of albumin expression is not sufficient to improve glucoregulation. Furthermore, it is now clear that although the response of female mice to HFD might be unique from how males generally respond, still the complete albumin deficiency in Alb−/− mice and the associated FFA reduction is capable of improving glucoregulation in females on this diet. The present results have implications for the role of albumin and FFA in the regulation of metabolism.
Primary health care coverage in Portugal: the promise of a general practitioner for all
Authors: Costa Eduardo , Pestana Joana , Barros Pedro Pita
Published: August 2024

Background

Primary care is an essential pillar of health systems. Many countries have implemented different policies to improve access to primary care. However, persistent challenges remain. This paper offers a critical analysis of the evolution of primary care coverage in Portugal, focusing on the number of patients without an assigned general practitioner (GP).

Methods

We collected and analyzed publicly available data from 2009 to 2023 to decompose primary care coverage in three components: the number of patients enrolled in primary care units (demand-side effect), the number of GPs measured in full-time equivalent (supply-side effect), and the average number of patients on each GP’s list (patient-to-GP ratio, capturing a productivity effect). We provide national and local level estimates for these three components.

Results

Between 2009 and 2023, there was an overall decline in the number of patients enrolled in primary health care units. Concurrently, there was also a net decrease of GPs measured in full-time equivalent. Additionally, there was a progressive reduction in the average number of patients on each GP’s list. The rise in the number of patients without an assigned GP is attributed not only to a reduction in the number of physicians, but also to a decrease in the patient load per doctor.

Conclusions

Hiring additional GPs may not suffice to enhance coverage. Achieving higher coverage may imply revisiting patient load per doctor or considering alternative care models. Understanding the challenges related to GP coverage is critical for improving the efficiency of primary care.
Shirebi granules ameliorate acute gouty arthritis by inhibiting NETs-induced imbalance between immunity and inflammation
Authors: Li Xin , Mao Xia , Jiang Hong , Xia Cong , Fu Lu , Gao Wenjing , Chen Wenjia , Li Weijie , Wang Ping , Zhang Yanqiong , Xu Haiyu
Published: August 2024

Background

Acute gouty arthritis (AGA) is classified as ‘arthritis’ in traditional Chinese medicine (TCM) theory. Shirebi granules (SGs), derived from the classic prescription SiMiaoWan, exerts satisfying therapeutic efficacy in ameliorating AGA clinically. However, the underlying mechanisms of SGs against AGA remain unclarified.

Methods

AGA-related biological processes, signal pathways and biomarker genes were mined from the GEO database through bioinformatics. SGs components were systematically recognized using the UPLC-Q-TOF–MS/MS. A correlation network was established based on the biomarker genes and the chemical components, from which the signal pathway used for further study was selected. Finally, we established an AGA model using SD rats injected with monosodium urate (MSU) in the ankle joint for experimental validation. A combination of behavioral tests, H&E, safranin O- fast green, western blotting, and immunofluorescence were employed to reveal the mechanism of action of SGs on AGA.

Results

The deterioration of AGA was significantly related to the imbalance between immunity and inflammation, neutrophil chemotaxis and inflammatory factor activation. HDAC5, PRKCB, NFκB1, MPO, PRKCA, PIK3CA were identified to be the candidate targets of SGs against AGA, associated with neutrophil extracellular traps (NETs) signal pathway. Animal experiments demonstrated that SGs effectively repaired cartilage damage, blocked TLR4 activation, and inhibited the expression of NETs indicators and inflammatory factors. In addition, SGs prominently alleviated joint redness and swelling, improved joint dysfunction, inhibited inflammatory infiltration of AGA rats.

Conclusion

Our data reveal that SGs may effectively alleviate the disease severity of AGA by suppressing NETs-promoted imbalance between immunity and inflammation.
Dachsous cadherin related 1 (DCHS1) is a novel biomarker for immune infiltration and epithelial-mesenchymal transition in endometrial cancer via pan-cancer analysis
Authors: Meijuan Cai , Fang Min , qian Wang
Published: August 2024

Background

Dachsous cadherin related 1 (DCHS1) is one of calcium-dependent adhesion membrane proteins and is mainly involved in the development of mammalian tissues. There is a lack of more detailed research on the biological function of DCHS1 in pan-cancer.

Materials and methods

We evaluated the expression, the prognostic value, the diagnostic value and genomic alterations of DCHS1 by using the databases, including TCGA, UALCAN, HPA, GEPIA2.0 and GSCA. We employed the databases of UCSC, TIMER2.0, TISIDB, GSCA to analyze the association between DCHS1 expression and the immune microenvironment, stemness, TMB, MSI and anticancer drug sensitivity. BioGRID, STRING and GEPIA2.0 were used to perform protein interaction and functional enrichment analysis. Real-time quantitative PCR, CCK8, Transwell assay and Western blot were performed to determine the function of DCHS1 in UCEC.

Results

DCHS1 is differentially expressed in many cancers and its expression is significantly associated with tumor prognosis and diagnosis. DCHS1 expression was significantly correlated with the infiltration of cancer-associated fibroblasts (CAFs), Endothelial cell (ECs), and Hematopoietic stem cell in most cancers. In addition, DCHS1 was significantly associated with sensitivity to many antitumor drugs. Functional enrichment analysis revealed that DCHS1-related proteins were involved in Focal adhesion, Endometrial cancer and Wnt signaling pathway. GSEA results showed that DCHS1 was related to epithelial-mesenchymal transition (EMT) in many cancers. In vitro experiments in UCEC showed that DCHS1 regulated cell proliferation, migration and EMT.

Conclusions

Our findings indicated that DCHS1 might be a novel prognostic and diagnostic biomarker and immunotherapy target, and plays an important role in the proliferation, migration and EMT in UCEC.
Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy
Authors: Lloyd Erin M. , Crew Rachael C. , Haynes Vanessa R. , White Robert B. , Mark Peter J. , Jackaman Connie , Papadimitriou John M. , Pinniger Gavin J. , Murphy Robyn M. , Watt Matthew J. , Grounds Miranda D.
Published: August 2024

Background

Dysferlinopathies are a clinically heterogeneous group of muscular dystrophies caused by gene mutations resulting in deficiency of the membrane-associated protein dysferlin. They manifest post-growth and are characterised by muscle wasting (primarily in the limb and limb-gridle muscles), inflammation, and replacement of myofibres with adipose tissue. The precise pathomechanism for dysferlinopathy is currently unclear; as such there are no treatments currently available. Glucocorticoids (GCs) are widely used to reduce inflammation and treat muscular dystrophies, but when administered to patients with dysferlinopathy, they have unexpected adverse effects, with accelerated loss of muscle strength.

Methods

To investigate the mechanistic basis for the adverse effects of GCs in dysferlinopathy, the potent GC dexamethasone (Dex) was administered for 4–5 weeks (0.5–0.75 µg/mL in drinking water) to dysferlin-deficient BLA/J and normal wild-type (WT) male mice, sampled at 5 (Study 1) or 10 months (Study 2) of age. A wide range of analyses were conducted. Metabolism- and immune-related gene expression was assessed in psoas muscles at both ages and in quadriceps at 10 months of age. For the 10-month-old mice, quadriceps and psoas muscle histology was assessed. Additionally, we investigated the impact of Dex on the predominantly slow and fast-twitch soleus and extensor digitorum longus (EDL) muscles (respectively) in terms of contractile function, myofibre-type composition, and levels of proteins related to contractile function and metabolism, plus glycogen.

Results

At both ages, many complement-related genes were highly expressed in BLA/J muscles, and WT mice were generally more responsive to Dex than BLA/J. The effects of Dex on BLA/J mice included (i) increased expression of inflammasome-related genes in muscles (at 5 months) and (ii) exacerbated histopathology of quadriceps and psoas muscles at 10 months. A novel observation was pronounced staining for glycogen in many myofibres of the damaged quadriceps muscles, with large pale vacuolated myofibres, suggesting possible myofibre death by oncosis.

Conclusion

These pilot studies provide a new focus for further investigation into the adverse effects of GCs on dysferlinopathic muscles.
“I’m not an anxious person”: end-of-life care workers constructing positive psychological states
Authors: Edmonds David Matthew , Zayts-Spence Olga
Published: August 2024

Background

Mental health is an issue of social and economic importance. Sociocultural and scholarly attention has largely focused on the negative aspects of mental health. That is, on mental disorders and illness and how they adversely impact our lives. In contrast, this paper forms part of a recent alternative empirical perspective in discourse-based research, by focusing on the positive aspects of mental health. In this article, we investigate how end-of-life care workers construct their positive psychological states.

Methods

Our data are 38 audio-recorded and transcribed semi-structured interviews with end-of-life care workers from Hong Kong and the United Kingdom. We utilized thematic analysis to identify common categorial strands across the data and discourse analysis to identify the linguistic strategies that these interviewees used to talk about their mental health.

Results

Our thematic analysis generated a superordinate theme across the interviews—namely, that of end-of-life care workers talking about their positive psychological states. We identify three generic ways that end-of-life care workers talked about these psychological states; by “foregrounding the positive,” “reformulating the negative,” and “dismissing the negative.” Our analysis also explicates how interviewees connected social and organizational support to being a benefit to their psychological states.

Conclusions

Our work contributes to existing discourse-based and sociolinguistic research on mental health by turning their focus towards a consideration of its positive dimensions. We also identify recurrent linguistics strategies used by people to construct their mental health. Our analyses point to the importance of investigating mental health as a multidimensional concept that considers participants’ own reflections on their mental health.
Clipped Axillary Node as a Potential Surrogate for Overall Axillary Nodal Status in Inflammatory Breast Cancer Patients after Neoadjuvant Chemotherapy
Authors: Lohani Kush R. , Hoskin Tanya L. , Yasir Saba , Olson Carrie A. , Boughey Judy C. , Hieken Tina J. , Degnim Amy C.
Published: August 2024

Background

Axillary lymph node dissection is the current standard for management of the axilla in inflammatory breast cancer (IBC). The present study aims to determine whether the initially positive node identified by clip placement accurately represents the overall nodal status of axilla after neoadjuvant chemotherapy (NAC) in IBC.

Patients and Methods

A retrospective study was conducted on patients with IBC who underwent operation (2014–2023). For patients with IBC who had clip placement in a positive axillary node at diagnosis, operative notes, specimen radiographs, and pathology reports were reviewed to confirm final pathologic status of clipped nodes.

Results

In total, 92 patients with IBC (90 cN+) were identified (median age 54 years, 78% invasive ductal, 10% invasive lobular, and 12% mixed); 81 (90%) were biopsy-proven cN+, with a clip placed in the positive node for 62/81 (77%). All patients were treated with NAC and axillary surgery with median 19 (range 4–49) nodes removed. Among 28 (out of 56) patients with retrieved clipped nodes that were pathologically negative (ypN0), only 1 had an additional positive node with micrometastasis for a false negative rate of 4% (95% CI 1–19%). Conversely, 3/3 patients with isolated tumor cells (ITCs) only in the clipped node had additional axillary disease (ITCs in 1, macrometastasis in 2), and 20/23 (87%) of patients with pathologically positive clipped node (micrometastasis or greater) had additional positive nodes [19/20 (95%) with macrometastasis].

Conclusions

The clipped biopsy-positive axillary node in IBC accurately represented the post-NAC overall axillary nodal status. ITCs post-NAC should be considered positive as an indicator of additional nodes with metastasis.
Is the reuse of abandoned nest material a characteristic of the genus Parachartergus Ihering, 1904 (Vespidae: Polistinae)?
Authors: Souza Jackie Anne  Silverio de , Renne Diego Gonçalves dos Santos , Souza Marcos Magalhães de , Jacques Gabriel de Castro
Published: August 2024

The social wasp species of the genus Parachartergus Ihering, 1904 (Vespidae: Polistinae) use plant fibers and saliva to build their nests, although two species are known to reuse material from abandoned nests belonging to other wasps. This paper aims to report the species Parachartegus pseudapicalis Willink, 1959, which has reused material from an abandoned social wasp nest. The record occurred at random, in November 2023, in the Atlantic Forest and Cerrado transition area, in the municipality of Luminárias, southern Minas Gerais, Brazil. The reported behavior is similar to that observed in Parachartegus fraternus (Gribodo, 1892) and Parachartegus colobopterus (Lichtenstein, 1796). This reuse may be frequent in Parachartergus, but further studies are suggested in order to better elucidate this behavior and its evolutionary significance.
Asset-Side Bank Runs and Liquidity Rationing: A Vicious Cycle
Authors: Huang Zongbo
Published: August 2024

I analyze runs on credit lines in an infinite-horizon banking model, focusing on the strategic complementarity between bankers and credit line borrowers. Panic drawdowns by borrowers coupled with bank liquidity rationing can mutually reinforce each other, creating a vicious cycle. Using data from U.S. banks, I estimate the model and quantify the amplification effect arising from strategic complementarity. This amplification effect accounted for two-thirds of the contraction of bank credit during the 2008–2009 crisis. Moreover, I show that policies targeting borrowers have a crowding-in effect and can effectively contain credit contraction.

This paper was accepted by Lukas Schmid, finance.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00872 .
Thomas Alva Edison: Bright Ideas from Menlo Park
Authors: Smith Nick
Published: August 2024

One of the more controversial figures in the history of engineering, legendary American inventor Thomas Edison’s significance extends beyond the perennial lightbulb controversy.
$SDD_1$ tensors and $B_1$-tensors
Authors: Duan Weiting , Wen Dekun , Wang Yaqiang
Published: August 2024

Strong $\mathcal{H}$-tensors play an important role in the fields of science and engineering. In this paper, we first propose a new subclass of strong $\mathcal{H}$-tensors that we call the class of $SDD_1$ tensors. We also prove that if a tensor is an $SDD_1$ tensor, it is a strong $\mathcal{H}$-tensor. As an application, a sufficient condition for an $SDD_1$ tensor to certify positive definiteness of even-order real symmetric tensors is proposed. Furthermore, we propose a new class of tensors by means of $SDD_1$ tensors, naming it $B_1$-tensors, and show that $B$-tensors are a subclass of it. Meanwhile, some properties of $B_1$-tensor were introduced. The numerical examples demonstrate the validity of our results.
Neonatal Septic Arthritis with Acyanotic CHD: A Case Study
Authors:   Department of Orthopaedics, Narayan Medical College and Hospital, Sasaram, Bihar, India., Suman Saurabh , Kamal Sushil ,   Department of Orthopaedics, Narayan Medical College and Hospital, Sasaram, Bihar, India., Vatsa Gaurav ,   Department of Orthopaedics, Narayan Medical College and Hospital, Sasaram, Bihar, India.
Published: August 2024

Introduction: Septic arthritis (SA) is the inflammation of the joints secondary to an infectious etiology, most commonly affecting the knee, hip, and shoulder. It is often an emergency condition and requires urgent intervention whether medical or surgical at the earliest. This case report highlights one such instance of timely intervention in a challenging scenario. Case Report: In this case report, we encountered a 29-day-old female neonate born at 38 weeks and 4 days to a primigravida mother with a birth weight of 2.8 kg who was diagnosed with the right knee joint SA with neonatal sepsis. The neonate was also found to be suffering with acyanotic congenital heart disease. Early arthrotomy with exploration of joint with antibiotic cover was the chosen line of treatment. Conclusion: Arthrotomy is a very good and established method to deal with SA. Early intervention is advised in these cases to ensure proper recovery without any complications. Keywords: Septic arthritis, neonate, knee joint, arthrotomy.
The Classification of Irarutu and Koiwai: A New Proposal
Authors: Schapper Antoinette , Zobel Erik
Published: August 2024

The classification of Irarutu and Koiwai, two Austronesian languages spoken in the vicinity of New Guinea’s Bomberai Peninsula, is unresolved. Competing proposals variously link the languages to the South Halmahera–West New Guinea group and the Central Malayo-Polynesian group. This article makes a novel proposal, positing that Irarutu and Koiwai subgroup together and, in turn, places them in a higher subgroup with the Seram Laut languages.
Naturalistic approach to investigate the neural correlates of a laundry cycle with and without fragrance
Authors: Gaeta Giuliano , Gunasekara Natalie , Pinti Paola , Levy Andrew , Parkkinen Emilia , Kontaris Emily , Tachtsidis Ilias
Published: August 2024

Advancements in brain imaging technologies have facilitated the development of “real-world” experimental scenarios. In this study, participants engaged in a household chore – completing a laundry cycle – while their frontal lobe brain activity was monitored using fNIRS. Participants completed this twice using both fragranced and unfragranced detergent, to explore if fNIRS is able to identify any differences in brain activity in response to subtle changes in stimuli. Analysis was conducted using Automatic IDentification of functional Events (AIDE) software and fNIRS correlation-based signal improvement (CBSI). Results indicated that brain activity, particularly in the right frontopolar and occasionally the left dorsolateral prefrontal cortex, was more pronounced and frequent with the unfragranced detergent than the fragranced. This suggests that completing tasks in an environment where a pleasant and relaxing fragrance is present might be less effortful compared to an odourless environment.
Taking advantage of reference-guided assembly in a slowly-evolving lineage: Application to Testudo graeca
Authors: Mira-Jover Andrea , Graciá Eva , Giménez Andrés , Fritz Uwe , Rodríguez-Caro Roberto Carlos , Bourgeois Yann
Published: August 2024

Background

Obtaining de novo chromosome-level genome assemblies greatly enhances conservation and evolutionary biology studies. For many research teams, long-read sequencing technologies (that produce highly contiguous assemblies) remain unaffordable or unpractical. For the groups that display high synteny conservation, these limitations can be overcome by a reference-guided assembly using a close relative genome. Among chelonians, tortoises (Testudinidae) are considered one of the most endangered taxa, which calls for more genomic resources. Here we make the most of high synteny conservation in chelonians to produce the first chromosome-level genome assembly of the genus Testudo with one of the most iconic tortoise species in the Mediterranean basin: Testudo graeca.

Results

We used high-quality, paired-end Illumina sequences to build a reference-guided assembly with the chromosome-level reference of Gopherus evgoodei. We reconstructed a 2.29 Gb haploid genome with a scaffold N50 of 107.598 Mb and 5.37% gaps. We sequenced 25,998 protein-coding genes, and identified 41.2% of the assembly as repeats. Demographic history reconstruction based on the genome revealed two events (population decline and recovery) that were consistent with previously suggested phylogeographic patterns for the species. This outlines the value of such reference-guided assemblies for phylogeographic studies.

Conclusions

Our results highlight the value of using close relatives to produce de novo draft assemblies in species where such resources are unavailable. Our annotated genome of T. graeca paves the way to delve deeper into the species’ evolutionary history and provides a valuable resource to enhance direct conservation efforts on their threatened populations.
Impact of eliminating retirement earnings test on labor supply and pension benefit claims
Authors: KITAMURA Tomoki , ADACHI Yoshimi
Published: August 2024

This study explores the hypothetical elimination of Japan’s retirement earnings test (ET) for public pensions, focusing on its implications for older workers’ labor supply and pension-claiming behaviors. The ET currently reduces public pension benefits for individuals aged 65 and older if their earnings exceed specified thresholds, potentially discouraging employment in this demographic. Notably, the Japanese ET influences both immediate and future pension benefits, thus diminishing current payouts for working pensioners and foregoing beneficial actuarial adjustments—adjustments based on actuarial calculations that would otherwise increase future benefits to account for delayed pension claims. This dual impact may discourage the labor supply and influence pension-claiming behavior among older workers. Through a survey-based experiment with male workers aged 40–59 years expected to face the ET upon retirement, we assess three reform scenarios as the first study in the literature: (1) eliminating future benefit reductions through actuarial adjustments, thereby enhancing the value of deferred pension claims; (2) removing immediate benefit suspensions to increase current pension payments directly; and (3) a comprehensive reform combining both approaches. Our findings reveal that eliminating reductions through actuarial adjustments increases the intensive margin (labor hours and income) and encourages delayed pension claims. Conversely, removing immediate benefit suspensions influences both the extensive margin (decision to work) and the intensive margin but leads to earlier pension claims. By highlighting the importance of differentiating between immediate and future benefit components in designing ET reforms, this study demonstrates their significant impact on labor supply and pension-claiming decisions.
Comparison of bone mineral density of runners with inactive males: A cross-sectional 4HAIE study
Authors: Krajcigr Miroslav , Kutáč Petr , Elavsky Steriani , Jandačka Daniel , Zimmermann Matthew
Published: August 2024

The purpose of the study was to determine whether running is associated with greater bone mineral density (BMD) by comparing the BMD of regularly active male runners (AR) with inactive nonrunner male controls (INC). This cross-sectional study recruited 327 male AR and 212 male INC (aged 18–65) via a stratified recruitment strategy. BMD of the whole body (WB) and partial segments (spine, lumbar spine (LS), leg, hip, femoral neck (FN), and arm for each side) were measured by dual-energy x-ray absorptiometry (DXA) and lower leg dominance (dominant-D/nondominant-ND) was established by functional testing. An ANCOVA was used to compare AR and INC. The AR had greater BMD for all segments of the lower limb (p<0.05), but similar BMD for all segments of the upper limb (p>0.05) compared with INC. Based on the pairwise comparison of age groups, AR had greater BMD of the ND leg in every age group compared with INC (p<0.05). AR had grater BMD of the D leg in every age group except for (26–35 and 56–65) compare with INC (p<0.05). In the youngest age group (18–25), AR had greater BMD in every measured part of lower extremities (legs, hips, femoral necks) compared with INC (p<0.05). In the 46–55 age group AR had greater BMD than INC (p < 0.05) only in the WB, D Leg, D neck, and ND leg. In the 56–65 age group AR had greater BMD than INC (p<0.05) only in the ND leg. Overall, AR had greater BMD compared with INC in all examined sites except for the upper limbs, supporting the notion that running may positively affect bone parameters. However, the benefits differ in the skeletal sites specifically, as the legs had the highest BMD difference between AR and INC. Moreover, the increase in BMD from running decreased with age.
Design and performance investigation of metamaterial-inspired dual band antenna for WBAN applications
Authors: Ali Usman , Ullah Sadiq , Basir Abdul , Yan Sen , Ren Hongwei , Kamal Babar , Matekovits Ladislau
Published: August 2024

This paper presents the design and analysis of a metamaterial-based compact dual-band antenna for WBAN applications. The antenna is designed and fabricated on a 0.254 mm thick semi-flexible substrate, RT/Duroid® 5880, with a relative permittivity of 2.2 and a loss tangent of 0.0009. The total dimensions of the antenna are 0.26λo×0.19λo×0.002λo, where λo corresponds to the free space wavelength at 2.45 GHz. To enhance overall performance and isolate the antenna from adverse effects of the human body, it is backed by a 2×2 artificial magnetic conductor (AMC) plane. The total volume of the AMC integrated design is 0.55λo×0.55λo×0.002λo. The paper investigates the antenna’s performance both with and without AMC integration, considering on- and off-body states, as well as various bending conditions in both E and H-planes. Results indicate that the AMC-integrated antenna gives improved measured gains of 6.61 dBi and 8.02 dBi, with bandwidths of 10.12% and 7.43% at 2.45 GHz and 5.80 GHz, respectively. Furthermore, the AMC integrated antenna reduces the specific absorption rate (SAR) to (>96%) and (>93%) at 2.45 GHz and 5.80 GHz, meeting FCC requirements for low SAR at both frequencies when placed in proximity to the human body. CST Microwave Studio (MWS) and Ansys High-Frequency Structure Simulation (HFSS), both full-wave simulation tools, are utilized to evaluate the antenna’s performance and to characterize the AMC unit cell. The simulated and tested results are in mutual agreement. Due to its low profile, high gain, adequate bandwidth, low SAR values, and compact size, the AMC integrated antenna is considered suitable for WBAN applications.
Lifestyle and mood correlates of cardiometabolic risk in people with serious mental illness on second-generation antipsychotic medications
Authors: Miedlich Susanne U. , Sahay Priya , Olivares Telva E. , Lamberti J. Steven , Morse Diane S. , Brazill Kevin P. , Chhabra Kavaljit H. , Bainbridge Lauren
Published: August 2024

Introduction

Cardiovascular morbidity and mortality are high in people with serious mental illness (SMI). This problem is mediated, at least in part, by metabolic side effects of second-generation antipsychotics (SGAs) and by unhealthy lifestyle behaviors. We asked whether oral glucose tolerance testing (oGTT) or hemoglobin A1c (HbA1c) is superior in identifying people with SMI at high cardiometabolic risk and whether this risk is shaped by mood, cognition, or lifestyle habits.

Methods

We evaluated 40 patients with schizophrenia, schizoaffective, or bipolar disorder receiving SGAs by oGTT, HbA1c, comprehensive metabolic and lipid panels, and CRP. Mood was assessed using the Patient Health Questionnaire (PHQ-9), and cognition was assessed using the Saint Louis University Mental Status examination. Diet was assessed using the UK Diabetes and Diet Questionnaire (UKDDQ), and physical activity was assessed using daily step counts.

Results

Most patients had prediabetes (preDM) or diabetes mellitus (DM), 72.5% by oGTT, and 52.5% by HbA1c criteria. Pulse rates and insulin resistance indices (Homeostatic Model Assessment of Insulin Resistance, HOMA IR; Matsuda) were significantly different between patients classified as normal or with preDM/DM, using either oGTT or HbA1c criteria. Patients with preDM/DM by HbA1c but not oGTT criteria also had higher waist/hip ratios, triglyceride, and CRP levels (p<0.05). A strong negative correlation was found between average daily step counts and CRP levels (rho = -0.62, p<0.001). Higher UKDDQ scores, or unhealthier diet habits, were associated with higher fasting plasma glucose (rho = 0.28, p = 0.08), triglyceride levels (rho = 0.31, p = 0.05), and insulin resistance (HOMA IR: rho = 0.31, p = 0.06). Higher PHQ-9 scores correlated with lower 2h-oGTT glucose levels (rho = -0.37, p<0.05).

Conclusions

OGTT screening is superior to HbA1c screening in detecting preDM and DM early. Patients identified with preDM/DM by oGTT or HbA1c screening are insulin-resistant and have higher pulse rates. Abdominal obesity, unfavorable lipid profiles, and higher CRP levels were noted in patients screened by HbA1c, but not by oGTT. Low physical activity, low depression scores, and unhealthy diet habits were associated with higher CRP and higher glucose and triglyceride levels, respectively. Future studies should assess the impact of specifically tailored individual lifestyle counseling and medical management interventions in this high-risk population.
Women’s participation in university management in Spain: The case of Andalusian universities
Authors: Rodríguez-Baiget María Josefa , Corpas-Reina Carmen , Maz-Machado Alexander , Linde-Valenzuela Gema del Rosario
Published: August 2024

This study addresses the presence of women in the management of Andalusian public universities, Spain. The aim of this study is to determine the representation of women in the administration and management of the administrative units of Andalusian public universities at faculty and department level, as well as to identify the distribution of university administration in terms of gender of managers in university centres according to the different macro-areas of the division of scientific knowledge. The method used was a descriptive study with quantitative and ex post facto values. A sample was selected from all public universities in the Autonomous Community of Andalusia, which represent 20% of all public universities in Spain. Information was collected from all academic units and the gender of each responsible administrator was determined. The data were deposited in a virtual repository. The results revealed that, in general, there is a disproportion in the predominance of male managers and administrators compared to the number of women involved in university management tasks in Andalusia. Imbalances in gender representation at different levels of management were observed, reflecting the inequalities reported in the literature. This study confirmed the existence of gender biases in university management, aligning with existing literature, which highlights the importance of addressing gender inequalities from a holistic perspective. The findings underline the importance of continuing to work on promoting gender equality in university management through multi-factorial approaches and concrete actions.
An unconstrained palmprint region of interest extraction method based on lightweight networks
Authors: Lin Chengrui , Chen Yifan , Zou Xiangqun , Deng Xiaoling , Dai Fen , You Junchao , Xiao Jinggui
Published: August 2024

Accurately extracting the Region of Interest (ROI) of a palm print was crucial for subsequent palm print recognition. However, under unconstrained environmental conditions, the user’s palm posture and angle, as well as the background and lighting of the environment, were not controlled, making the extraction of the ROI of palm print a major challenge. In existing research methods, traditional ROI extraction methods relied on image segmentation and were difficult to apply to multiple datasets simultaneously under the aforementioned interference. However, deep learning-based methods typically did not consider the computational cost of the model and were difficult to apply to embedded devices. This article proposed a palm print ROI extraction method based on lightweight networks. Firstly, the YOLOv5-lite network was used to detect and preliminarily locate the palm, in order to eliminate most of the interference from complex backgrounds. Then, an improved UNet was used for keypoints detection. This network model reduced the number of parameters compared to the original UNet model, improved network performance, and accelerated network convergence. The output of this model combined Gaussian heatmap regression and direct regression and proposed a joint loss function based on JS loss and L2 loss for supervision. During the experiment, a mixed database consisting of 5 databases was used to meet the needs of practical applications. The results showed that the proposed method achieved an accuracy of 98.3% on the database, with an average detection time of only 28ms on the GPU, which was superior to other mainstream lightweight networks, and the model size was only 831k. In the open-set test, with a success rate of 93.4%, an average detection time of 5.95ms on the GPU, it was far ahead of the latest palm print ROI extraction algorithm and could be applied in practice.
Peripheral white blood cell patterns in children with hydrocephalus as a response to ventriculo-peritoneal shunt infection
Authors: Polis Bartosz , Zeman Krzysztof , Zakrzewski Krzysztof , Fabijan Artur , Nowosławska Emilia
Published: August 2024

Shunt infection is one of the most common complications of conventional hydrocephalus treatment. The route of invasion of a pathogen can modify the immune response of the CNS. The aim of the study is to analyze the immune response to shunt infection caused by S. epidermidis in children with hydrocephalus. The immune response to the pathogen will be analyzed on the basis of, inter alia, simple laboratory test results, such as changes in the pattern of white blood cells, including neutrophils, monocytes, and lymphocytes. The entire study analyzes changes in general parameters of the cerebrospinal fluid (pleocytosis, protein level, glucose level) and in levels of selected interleukins (IL-6, CXCL8 / IL-8, CCL3 / MIP-1a) in the cerebrospinal fluid. The clinical material analyzed in the study was collected in 2010–2014. The study group consisted of 30 patients, who were admitted to the hospital due to their first-ever episode of valve dysfunction caused by S. epidermidis infection. The control group consisted of 30 children who also suffered from congenital hydrocephalus but had not been operated on before. The most pronounced response to CSF infection in the study group was a significant increase in the counts of all investigated WBC lines in the samples collected immediately after the patients’ admission to the ward. The earliest aberration of the CSF was a significant increase in protein level. An infection of a ventriculoperitoneal shunt caused by S. epidermidis evokes a very early peripheral blood response. In children affected by a ventriculoperitoneal valve infection, the humoral immune response detected in the cerebrospinal fluid precedes the increase in the level of pleocytosis. The highest level of cytokines in the cerebrospinal fluid is achieved when the pathogens are cleared. Phagocytes, and, in particular, monocytes, play an important role in the normalization of the cerebrospinal fluid parameters after the elimination of S. epidermidis. The local immune response of the central nervous system plays an important role in extinguishment of the inflammatory process.
Multi-physical field simulation calculation and analysis of simulated high-level waste liquid spray calcination
Authors: CHENG Yanmei , LI Kening , JIA Xingyun , YE Guoan
Published: August 2024

Aiming at the independent research and development of a simulated high-level waste liquid spray calcination transformation treatment test device, a three-dimensional multi-physical field model of spray calcination was established by means of finite element analysis method. In this paper, the simulated high-level waste liquid is a mixed solution of nitrate solution and sucrose. The main chemical components of nitrate dissolution are HNO3 and NaNO3. The process of evaporation and calcination of high-level waste liquid to form oxides is also called the pretreatment of high-level waste liquid or the conversion of high-level waste liquid. In this experiment, the atomized droplets sprayed at high speed are evaporated, dried and calcined in turn in the calciner to obtain the calcined product. The distribution law of temperature flow field and chemical reaction state and results inside the test device were revealed by simulation calculation. The results show that under the condition of multi-physical field coupling, the chemical reaction temperature has an effect on the yield of the product. The temperature is positively correlated with the product concentration, and the effect of temperature on the yield of NO2 is greater than that of Na2O. At the same time, in this chemical reaction, the concentration of reactants (NaNO3 and HNO3) had a positive correlation with the concentration of main products (NO2 and Na2O). However, the rate of increase in the concentration of the main products (NO2 and Na2O) decreased with the increase of the concentration of the reactants (NaNO3 and HNO3).
The impact of directors’ information technology experience on the financing constraints of internet start-ups—Data mining with python on the China’s New OTC market
Authors: Xu Huiji , Wang Senqiang , Wang Jianping , Liu Xiuyu , Chi Kaoxun
Published: August 2024

In the era of Internet information technology, the IT background of directors plays a significant role in corporate governance. However, existing research lacks sufficient discussion on the financing constraints faced by Internet startups. This paper examines Internet entrepreneurial enterprises listed on the New Third Board as the research sample. Using content analysis coding methods and Python software for text mining, the study empirically analyzes the impact of directors’ IT backgrounds and media reports on the financing constraints of these enterprises. The results indicate the following: First, directors with IT backgrounds help reduce the financing constraints of Internet startups. The higher the directors’ proficiency in information technology, the more favorable it is for obtaining financing. Second, directors with IT backgrounds have a significant positive impact on the tone of media reports. Third, the tone of media reports reflects the spirit and development of the enterprises, serving as a mediating factor between directors’ IT backgrounds and the financing constraints of the enterprises. The findings of this study are valuable for guiding Internet startups to better leverage the IT expertise of their directors. Additionally, they provide useful insights for reducing the financing constraints faced by these startups.
Research on comprehensive evaluation & development of aesthetic education based on PCA and CEM model
Authors: Xu Xin-Hong , Niu Yu-Ting , Li Zhi-Min , Xu Yue-Yang , Cao Ke-Wang
Published: August 2024

Aesthetic education, conveyed through public art courses, serves as a vital form of humanistic literacy education. It represents an effective approach to fostering innovative and creative thinking among college students. In order to effectively analyze the aesthetic education work of 46 universities, an aesthetic education index evaluation system is constructed, involving indicators including faculty strength, curriculum setting, teaching management, artistic practice, and teaching support. The secondary indicators corresponding to the five indicators are statistically analyzed, and a comprehensive evaluation analysis of the current development status of aesthetic education in 46 universities in Anhui Province is conducted by combining theoretical analysis with empirical analysis. Based on principal component analysis, an integrated evaluation model for the development of aesthetic education in universities in Anhui Province is further constructed. The model designed quantifies the influence weight of each aesthetic education index on the development of aesthetic education in Anhui Province, and forges a theoretical basis for determining the precursors of rapid development of aesthetic education in Anhui Province. Additionally, a novel approach is introduced to gauge the progression of aesthetic education within universities in Anhui Province, considering the dispersion of aesthetic education index data across the province. The comprehensive evaluation model for the development of aesthetic education in Anhui Province exhibits an overall declining trend. Hence, it is suggested to utilize the maximum value of the first derivative of the comprehensive evaluation model as an indicator of the imminent rapid development of aesthetic education in Anhui Province. On this basis, the probability equation of sustainable development of aesthetic education in Anhui Province is defined. Overall, the research results lay a theoretical foundation for the development of aesthetic education in Anhui Province.