bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Body Mass Index on Mortality and Morbidity in Patients Undergoing Coronary Artery Bypass Grafting Surgery
Authors: Akarsu Serkan , Kan Ä°rem Ä°ris , Sevingil Tolunay , Tok Mustafa
Published: October 2016

Background: This study aims to investigate the effect of body mass index (BMI) on mortality and morbidity in patients undergoing coronary artery bypass grafting (CABG) surgery.Methods: We retrospectively evaluated the medical records of 403 patients undergoing coronary artery bypass surgery in our center. The patients were divided into 5 groups according to their BMI values. Preoperative demographic characteristics, operative data, and postoperative complications during the six-month follow-up period were compared between the groups. Results: There were no statistically significant differences between the groups except the coexistence of peripheral artery disease (P = .009), ejection fraction (P = .021) and chronic obstructive pulmonary disease (P = .044). There were no statistically significant differences between the groups in terms of postoperative complications. No relationship was found between postoperative complications and the implemented surgical procedures. An overall 30-day mortality rate of 1.48% was observed, and the six-month mortality rate was 1.7%.Conclusion: According to this study, obesity does not lead to an increased risk of mortality and other adverse outcomes after CABG surgery. However, obesity may prolong hospital stay and increase the cost of CABG operation.
The Use of Bilateral Internal Mammary Arteries for Coronary Revascularization in Patients with COPD: Is It a Good Idea?
Authors: Hegazy Yasser Yehia , Sodian Ralf , Hassanein Wael , Rayan Amr , Ennker Juergen
Published: October 2016

Background: The use of bilateral internal mammary arteries (BIMA) is limited worldwide, especially in patients with chronic obstructive pulmonary disease (COPD). Thus, we assessed the safety of the use of BIMA in COPD patients.Methods: From cohorts of 8846 patients operated on at our center for primary isolated multi-vessel coronary bypass operations between 2002 and 2012, we studied two propensity-matched groups of patients with COPD who received either single internal mammary artery and saphenous vein grafts (SIMA group: 137 patients) or exclusively BIMA (BIMA group: 137 patients). Preoperative data were similar regarding age (63.59 ± 10.62 versus 65.55 ± 9.61 years; P = .10), body mass index (BMI) (28.6 ± 4.71 versus 28.42 ± 3.86 kg/m2; P = .72), diabetes mellitus (32% versus 27%; P = .08), EuroSCORE (4.34 ± 2.23 versus 4.8 ± 2.52; P = .09) and ejection fraction (58.7 ± 13.08% versus 60.29 ± 14.13%; P = .32). Results: No significant differences were noticed between the two groups regarding the number of peripheral anastomoses (3.07 ± 0.77 versus 3.06 ± 0.85; P = .90), total operation time (192.17 ± 43.06 versus 200.63 ± 39.24 min; P = .08), postoperative stroke (0.7% versus 0%; P = .29), myocardial infarction (2.92% versus 3.6%; P = .81), reintubation (2.9% versus 4.4%; P = .66), reexploration (0.7% versus 2.2%; P = .32), deep sternal wound infection (2.9% versus 3.6%; P = .81) and 30-day mortality (2.2% versus 2.9%; P = .77). However, postoperative blood loss (726.1 ± 468.35  versus 907 ± 890.58 mL; P = .03) was higher in the BIMA group. Conclusion: COPD patients can benefit from coronary artery revascularization with BIMA; however, postoperative blood loss can be higher using this technique.
Total Artificial Heart Implantation Blood Pressure Management as Resolving Treatment for Massive Hemolysis following Total Artificial Heart Implantation
Authors: Ghodsizad Ali , Koerner Michael M. , El-Banayosy A , Zeriouh Mohamed , Ruhparwar Arjang , Loebe Matthias
Published: October 2016

The SynCardia Total Artificial Heart (TAH) has been used for patients with biventricular failure, who cannot be managed with implantation of a left ventricular (LV) assist device. Following TAH implantation, our patient developed severe hemolysis, which could only be managed successfully by aggressive blood pressure control [Ohashi 2003; Nakata 1998].
Pregnancy-Related Cardiovascular Complications: Case Presentation and Review of Literature
Authors: Altinsoy Hasan Baki , Alatas Ozkan , Colak Salih , Atalay Hakan , Dogan Omer Faruk
Published: October 2016

Background: Cardiovascular complications that can cause severe catastrophic outcomes for both the mother and the fetus are rarely seen during pregnancy. Time to diagnosis is often delayed by a low degree of suspicion and atypical presentation. We report surgical strategies in three pregnant women with cardiovascular complications. Methods: A retrospective search from 2009 to 2016 identified three pregnant women who underwent urgent cardiac surgery. We used extracorporeal circulation (ECC) without cesarean section with careful follow-up of the fetuses during the perioperative and postoperative period. We used levosimendan as a potent inodilator in all patients to increase feto-placental blood flow and fetal heart rhythm.Results: Median time to diagnosis was 23.8 h (range 11.7-120 h) and median time from diagnosis to arrival in the operating theater was 9.8 h (range 7.4-19.8 h). One patient with prosthetic heart valve thrombosis underwent concomitant cesarean section prior to cardiac surgery. In a young pregnant woman who had spontaneous dissection of the left anterior descending artery, on-pump beating heart coronary artery bypass grafting was performed without cross clamping. Two and three months after surgery, cesarean sections were performed without any complication in two pregnant women.Conclusion: Because unusual cardiovascular complications are the main cause of maternal and/or fetus death during pregnancy, prompt and exact diagnosis is very important. Life-saving surgical strategy with the help of appropriate teams are necessary to optimize outcome for both mother and baby.
Spontaneous Coronary Artery Dissection after Minimally Invasive Mitral Valve Repair
Authors: Muretti Mirko , Manca Mario , Massi Francesco , Portoghese Michele
Published: October 2016

Spontaneous coronary artery dissection is a rare condition usually encountered in young women without risk factors for atherosclerotic disease but with tortuous coronary artery or contemporary presence of fibromuscular dysplasia. Sometimes spontaneous coronary dissection occurs in patients with atherosclerotic disease, although without significant epicardial coronary artery stenosis. We report a case of a patient who underwent minimally invasive mitral valve repair, whose initially uneventful postoperative course was complicated by spontaneous coronary artery dissection of the left main causing a life threatening condition. A subsequent emergency sternotomy was required to perform a coronary artery bypass.
Always Keep Your Clothes in the Car
Authors: Tribble Curtis G
Published: October 2016

In helping to organize many different educational environments in the School of Medicine and the Department of Surgery at the University of Virginia over the last 30 years, my colleagues and I have long recognized that our students and trainees, while uniformly well prepared academically for their respective missions, often take inadequate care of themselves. Everyone who has flown on a plane will recall that the flight attendants always tell passengers that, if oxygen is needed, one must put one’s own mask on first, before helping others put their masks on. And the obvious reason for that admonition is that you cannot help others if you, yourself, are impaired. This admonition applies equally to those who have committed their lives to helping others, which, in the case of our protÃ©gÃ©s and ourselves, is through medicine and surgery.
School-Located Influenza Vaccinations: A Randomized Trial
Authors: Szilagyi Peter G. , Schaffer Stanley , Rand Cynthia M. , Vincelli Phyllis , Eagan Ashley , Goldstein Nicolas P.N. , Hightower A. Dirk , Younge Mary , Blumkin Aaron , Albertin Christina S. , Yoo Byung-Kwang , Humiston Sharon G.
Published: October 2016

OBJECTIVE:

Assess impact of offering school-located influenza vaccination (SLIV) clinics using both Web-based and paper consent upon overall influenza vaccination rates among elementary school children.

METHODS:

We conducted a cluster-randomized trial (stratified by suburban/urban districts) in upstate New York in 2014–2015. We randomized 44 elementary schools, selected similar pairs of schools within districts, and allocated schools to SLIV versus usual care (control). Parents of children at SLIV schools were sent information and vaccination consent forms via e-mail, backpack fliers, or both (depending on school preferences) regarding school vaccine clinics. Health department nurses conducted vaccine clinics and billed insurers. For all children registered at SLIV/control schools, we compared receipt of influenza vaccination anywhere (primary outcome).

RESULTS:

The 44 schools served 19 776 eligible children in 2014–2015. Children in SLIV schools had higher influenza vaccination rates than children in control schools county-wide (54.1% vs 47.4%, P < .001) and in suburban (61.9% vs 53.6%, P < .001) and urban schools (43.9% vs 39.2%; P < .001). Multivariate analyses (controlling for age, grade, vaccination in previous season) confirmed bivariate findings. Among parents who consented for SLIV, nearly half of those notified by backpack fliers and four-fifths of those notified by e-mail consented online. In suburban districts, SLIV did not substitute for primary care influenza vaccination. In urban schools, some substitution occurred.

CONCLUSIONS:

SLIV raised seasonal influenza vaccination rates county-wide and in both suburban and urban settings. SLIV did not substitute for primary care vaccinations in suburban settings where pediatricians often preorder influenza vaccine but did substitute somewhat in urban settings.
Indoor Environmental Control Practices and Asthma Management
Authors: Matsui Elizabeth C. , Abramson Stuart L. , Sandel Megan T. ,   SECTION ON ALLERGY AND IMMUNOLOGY,   COUNCIL ON ENVIRONMENTAL HEALTH, Dinakar Chitra , Irani Anne-Marie , Kim Jennifer S. , Mahr Todd A. , Pistiner Michael , Wang Julie , Lowry Jennifer A. , Ahdoot Samantha , Baum Carl R. , Bernstein Aaron S. , Bole Aparna , Brumberg Heather L. , Campbell Carla C. , Lanphear Bruce P. , Pacheco Susan E. , Spanier Adam J. , Trasande Leonardo
Published: October 2016

This Clinical Report was reaffirmed February 2024.

Indoor environmental exposures, particularly allergens and pollutants, are major contributors to asthma morbidity in children; environmental control practices aimed at reducing these exposures are an integral component of asthma management. Some individually tailored environmental control practices that have been shown to reduce asthma symptoms and exacerbations are similar in efficacy and cost to controller medications. As a part of developing tailored strategies regarding environmental control measures, an environmental history can be obtained to evaluate the key indoor environmental exposures that are known to trigger asthma symptoms and exacerbations, including both indoor pollutants and allergens. An environmental history includes questions regarding the presence of pets or pests or evidence of pests in the home, as well as knowledge regarding whether the climatic characteristics in the community favor dust mites. In addition, the history focuses on sources of indoor air pollution, including the presence of smokers who live in the home or care for children and the use of gas stoves and appliances in the home. Serum allergen-specific immunoglobulin E antibody tests can be performed or the patient can be referred for allergy skin testing to identify indoor allergens that are most likely to be clinically relevant. Environmental control strategies are tailored to each potentially relevant indoor exposure and are based on knowledge of the sources and underlying characteristics of the exposure. Strategies include source removal, source control, and mitigation strategies, such as high-efficiency particulate air purifiers and allergen-proof mattress and pillow encasements, as well as education, which can be delivered by primary care pediatricians, allergists, pediatric pulmonologists, other health care workers, or community health workers trained in asthma environmental control and asthma education.
Handoffs: Transitions of Care for Children in the Emergency Department
Authors:   AMERICAN ACADEMY OF PEDIATRICS Committee on Pediatric Emergency Medicine,   AMERICAN COLLEGE OF EMERGENCY PHYSICIANS Pediatric Emergency Medicine Committee,   EMERGENCY NURSES ASSOCIATION Pediatric Committee
Published: October 2016

This Policy Statement was reaffirmed December 2020.

Transitions of care (ToCs), also referred to as handoffs or sign-outs, occur when the responsibility for a patient’s care transfers from 1 health care provider to another. Transitions are common in the acute care setting and have been noted to be vulnerable events with opportunities for error. Health care is taking ideas from other high-risk industries, such as aerospace and nuclear power, to create models of structured transition processes. Although little literature currently exists to establish 1 model as superior, multiorganizational consensus groups agree that standardization is warranted and that additional work is needed to establish characteristics of ToCs that are associated with clinical or practice outcomes. The rationale for structuring ToCs, specifically those related to the care of children in the emergency setting, and a description of identified strategies are presented, along with resources for educating health care providers on ToCs. Recommendations for development, education, and implementation of transition models are included.
The Use of Systemic and Topical Fluoroquinolones
Authors: Jackson Mary Anne , Schutze Gordon E. ,   COMMITTEE ON INFECTIOUS DISEASES
Published: October 2016

Appropriate prescribing practices for fluoroquinolones, as well as all antimicrobial agents, are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children has become better defined. Earlier recommendations for systemic therapy remain; expanded uses of fluoroquinolones for the treatment of certain infections are outlined in this report. Prescribing clinicians should be aware of specific adverse reactions associated with fluoroquinolones, and their use in children should continue to be limited to the treatment of infections for which no safe and effective alternative exists or in situations in which oral fluoroquinolone treatment represents a reasonable alternative to parenteral antimicrobial therapy.
КІЛЬКІСНИЙ І ЯКІСНИЙ АМІНОКИСЛОТНИЙ СКЛАД М’ЯСА КУРЧАТ–БРОЙЛЕРІВ ЗА ЗБАГАЧЕННЯ РАЦІОНУ НАНОМІКРОЕЛЕМЕНТНОЮ КОРМОВОЮ ДОБАВКОЮ «МІКРОСТИМУЛІН»
Authors: Kirichenko V.N.
Published: October 2016

The work analyzes qualitative and quantitative amino acid composition of broiler meat for diet enrichment nanotracelement feed additive «Mikrostymulin». It was founded that poultry muscle in control and experimental groups contain such essential amino acids, as threonine, valine, isoleucine, leucine, phenylalanine, lysine, methionine, and tryptophan tsystin. Research the quality of the essential amino–acids showed the presence of aspartic acid, serine, glycine, tyrosine, alanine, glutamic acid, proline, histidine, arginine and oxyproline.It was established that the use of «Mikrostymulin» increases the content of amino acids in meat of broiler chickens. In muscles of broiler chickens in the 1st research group, have beenadded «Mikrostymulin» in a dose of 1 ml/dm³ of water, the amount of essential amino acids and replacement tends to increase at chest and hip muscles, compared with the contro group.. Obviously, this can be explained by improved assimilation of food and stimulating the synthesis of amino acids under the influence of the components of the feed additive. In chickensof the 2nd research group,they received «Mikrostymulin» at a dose of 10 ml/dm³ water, it was registered a tendency to increase essential amino acids in the pectoral muscles, but in the femoral – it was tendency to decrease. In chickens of the 3 rd research group, they received«Mikrostymulin» at a dose of 20 ml/dm³ water, it was registered a tendency to reduce the amount of essential amino acids in the chest and thigh muscles. Number of essential amino–acids in chicken pectoral muscle in the 2 nd experimental group also increased slightly, and in the3 rd – reduced slightly, but in the femoral muscles they decreased slightly in the 2 nd and 3 rd experimental groups compared to control group.It is proved that the use of nanotracelement feed additive «Mikrostymulin» in a dose of 1 ml / dm³ of water improves the quality and increases the biological value of meat.
ЯКІСНІ ЗМІНИ МОЛОКА–СИРОВИНИ ЗА ВПЛИВУ РІЗНИХ ГІГІЄНІЧНИХ УМОВ ОТРИМАННЯ
Authors: Kondrasiy L. , Yakubchak O.
Published: October 2016

In Ukraine still remains relevant practice testing and purchase of raw milk by four quality classes. But for a long time in Ukraine working farms with modern methods zootechnical and veterinary management, with good dairy farming practices and good milking hygienepractices. So the aim of our study was to compare total bacteria count and somatic cells count in raw milk from this farms and farms that are still provided traditional (where were found some mistakes in milking hygiene practices) dairy farming practices in Ukraine. The qualityparameters of raw milk were collected from farms located in Kiev, Cherkassy, Poltava, Chernihiv and Vinnitsa regions of Ukraine. Totally –17 farms in both groups. Research period – one year (2015/12–01). In the paper presented results of stability during the year of the quality parameters of raw milk received from farms of some regions of Ukraine. Farms which were taken for the study were divided into two groups, by various dairy farming practices. The stability evaluation was performed by intervals of determinations of total bacteria count rate and somatic cells count in milk. The intervals of determinations were defined according to Ukraine standard 3662–97. Established that total bacteria count and somatic cells count rate of raw milk from farms with good dairy farming practices was at one and three intervals, respectively. So, for these raw milk we can recommended periodic testing. The intervals of determinations of total bacteria count and somatic cells count of raw milk from farms, were found some mistakes in milking hygiene practices varied, at 3 and 2 intervals respectively and divided in equal parts by the percentage. The value of the monthly average rate of somatic cells count in milk predominated in the largest range (from 500 to 600 ×1000/mL). Consequently, raw milk, from this farm has no predictability throughout the year and requires frequent checks of safety and quality.
ВПЛИВ ПРОБІОТИКА ТА ФІТОБІОТИКА НА КИШКОВИЙ МІКРОБІОЦЕНОЗ ВІДЛУЧЕНИХ ПОРОСЯТ ЗА НЕСПЕЦИФІЧНОГО ГАСТРОЕНТЕРИТУ
Authors: Lukashchuk B.O. , Slivinska L.G.
Published: October 2016

The article presents results of probiotic TOYOCERIN 109 and phytobiotic EXTRACT™ 6930 influence as part of the basic diet of weaned piglets with nonspecific gastroenteritis in combination with antibiotic (10% enrofloxacin hydrochloride solution) on intestinal microbiocenosis in modern pig farm.Using of probiotic and phytobiotic in combination with antibiotic contributed to disappearance of the major clinical symptoms in pigs of third and fourth experimental groups in 3 days after treatment, whereas in piglets of second experimental group in 5 day .As a result of microbiological studies of weaned piglets feces with nonspecific gastroenteritis we found a change of intestinal microflora.The use of probiotic TOYOCERIN 109 and phytobiotic EXTRACT™ 6930 in combination with antibiotics (10% enrofloxacin hydrochloride solution) for weaned piglets for 5 days helped reduce the number of pathogenic microflora to the level of healthy piglets.Also established a positive effect of probiotic and phytobiotic in combination with antibiotic in normal microflora of gastrointestinal tract, as indicated by normalization of number of the genus Bifidobacterium and Lactobacillus representatives.
МОРФОФУНКЦІОНАЛЬНА ХАРАКТЕРИСТИКА ПЕЧІНКИ ЗА ВИЗНАЧЕННЯ КУМУЛЯТИВНИХ ВЛАСТИВОСТЕЙ ФІТОПРЕПАРАТУ «ЩИТНИК»
Authors: Perig G.
Published: October 2016

The article presents the results of study of the search influence of the preparation «Shchytnyk» in the form of dry extract got from the roots of masculine ferns (Rhizoma Dryopteris filix–mas, order of many–stems –Polypodiaceae), on the coefficients of the mass of internal organs, some biochemical parameters of blood and morphological structure of rat liver in conditions of cumulation.To determine the cumulative properties of the preparation «Shchytnyk » was used test method «subchronical toxicity» . The experiment was conducted on 18 white rats, 2 – months old, with body mass of 140 – 160g, which were formed into two groups of animals– analogues: I – control, II – research (9 animals in each). To enter a drug it was dissolved in propylene glycol with water in a ratio of 1: 1. Rats of experimental drug were administered orally every day, starting with a dose of 1300 mg/kg (representing 1/10 DL50), followed by increasing doses of 1.5 times every 4 days. The animals from the control group were injected with solvent.The introduction of a new antiparasitis drug to rats «Shchytnyk» for 24 consecutive days at a total dose of 36196,9 mg/kg caused an increase coefficients in liver weight ratios, increased activity of alkaline phosphatase, liver transaminases in serum compared to control, that histologically confirmed dystrophic–necrotic changes in the parenchyma of the liver, and were characterized with the expansion of central venous and intra–lobular capillaries, cariorecsise, grit cytoplasm of hepatocytes.
ЕФЕКТИВНІСТЬ «МАЗІ ДЛЯ РАН» У КОМПЛЕКСНІЙ ТЕРАПІЇ ПРИ ЛІКУВАННІ РВАНИХ РАН ДІЙОК ВИМЕНІ КОРІВ
Authors: Sachuk R.N.
Published: October 2016

In the study of cows’ mammary glands pathologies it was determined that the udder wounds constitute 1.2% in the overall structure of diseases. The peak of traumatism on cows’ breast wounds falls on summer (pasture–range period) – 77.3%, resulting from offences of sanitary requirements for cattle pasture and grazing. While testing new treatment regimens it was set the high efficiency of «Ointments for wounds» based on essential oils of Siberian Cedar, Eucalyptus, Clove, Cedar, Tea Tree and chlorophyllipt oil solution for treatment of avulsive wounds of cows’ udder teats. It has been proven the reducing of time for treatment compared with traditional drugs «Oxytetracycline Ointment 5%» containing oxytetracycline – a semisynthetic antibiotic of a tetracycline series. Complex therapy, including application of preparation for external use «Ointment for wounds» and hypodermic injection of NSAID «Celecoxib», together with the wound defects closing by sutures with polyglycolide, promotes rapid correction of the clinical condition of cows. It was observed upregulating of hemoglobin by 6.1%, the number of erythrocytes – 11.4%, leukocytes – 9% in the blood, compared with the traditional method of treatment («Oxytetracycline Ointment 5%» and nonsteroidal drug «Kefen»). Local application of phytopreparation «Ointments for wounds» and hypodermic injection of NSAID «Celecoxib» promotes acceleration of inflammatory reactions cancellation in 1,3 times, reduce udder edema – 1.2 times and enhance regenerative processes, thereby reducing treatment time 5 – 6 days compared to control animals.
ТЕЛОМЕРНА ТЕОРІЯ СТАРІННЯ КЛІТИНИ
Authors: Stakhiv O. , Shemediuk N.
Published: October 2016

Among the row of theories that explain the phenomen on of aging, the large attention of the modern scientific world is turn to ed a side of telomer theory. From this point of view, aging is a result of damage to the genetic apparat. A process is programed and relatedto expression of genes of old «age» on the certain stage of ontogenesis, that are  reason  destructive  changes in a cell. The presence Heynflick`s limit and telomer meter of division of cell sustains this theory. The telomere theory of aging has research of intercommunication of akey moments between the type of cells, presence in a functionally active telomeraza and by stopping of cellular cycle. The telomeraza mechanism of action is building of  sequences of  nucleotide  in  the  areas of DNA, that is lost with every division of cells. Disruption of the body is a result of the telomere shortening after every cycle of DNA replication. It doesn’t depend on time, but from the amount of replication of DNA and it can be replicometr, that determines the amount of cell divisions. After the achievement critical length of telomeric DNAsegments a cellular cycle is stopped in G1 or G2/M phases. Enzyme contains TERT (telomerase reverse transcriptase), TER (telomerase RNA). An important catalytic domen which inherent reverse transcriptases, domen of joining TER, DNA–substrate, are part of TERT. Onthis  time question of searching activators of telomeraza is actual, sciens are interested in it so that number of advanced studies are increase every year.
ДІАГНОСТИКА ХРОНІЧНОЇ СЕРЦЕВОЇ НЕДОСТАТНОСТІ СОБАК – ІСНУЮЧІ МЕТОДИ ТА ПОДАЛЬШІ ПЕРСПЕКТИВИ
Authors: Trofimjak R. , Slivinska L.
Published: October 2016

The article analyzes the current scientific work related to the study of processes of chronic heart failure (CHF), and the use of biomarkers in the diagnosis of heart disease in dogs. Thoracic radiography, electrocardiography, and echocardiography are used to diagnose heart disease in dogs but despite the use of non–invasive methods, there is uncertainty about the severity of the disease and prognosis for each patient individually. In veterinary practice for the diagnosis of myocardial lesions in animals are clinically valuable, highly sensitive and simple to use cardiac biomarkers. A biomarker is typically a substance in the blood that can be objectively measured and indicates a biologic or pathologic process or response to therapy.1 There are scores of cardiac biomarkers,but this article will focus on the 2 most clinically useful ones in the dog and cat:cardiac troponin I (cTnI) and N–terminal pro–B–type natriuretic peptide (NT–proBNP). The cardiac troponins I, T, and C (cTnI, cTnT, and cTnC) are thin filament–associated regulatory proteins of the heart muscle. Cardiac troponin I («I» for inhibition) is uniquely expressed in the myocardium and is a potent inhibitor of the process of actin–myosin cross–bridge formation. The molecular weight is 24.000 D. Cardiac troponin T («T» for tropomyosin binding) has a molecular weight of 37.000 D and binds the troponin complex to tropomyosin. Cardiac troponin C («C» for calcium) binds to calcium and starts, therefore, the crossbridge cycle. As with cTnI, approximately 95% of cTnT in man and dogs is myofibril bound and about 5% is cytosolically dissolved. Mechanisms for an elevation in circulating cardiac troponins include an increase of myocyte membrane permeability (initial release of the cytosolic troponin pool) or cell necrosis (release of myofibrilbound troponins). Four to six hours after acute myocardial cell injury, the cardiac troponin concentration in blood increases in a biphasic pattern. Plasma half–life of cardiac troponins is approximately two hours, and elimination mainly occurs via the reticuloendothelial system (cTnI and cTnT) and renal loss (cTnT). Cardiac troponins are phylogenetically highly preserved proteins with a more than 95% total structural agreement between mammals. Therefore, established human serologic tests for troponin analysis may be used reliably in pets as well. Myocardial cell injury, manifested anatomically as inflammation (endomyocarditis, myocarditis, perimyocarditis), acute degeneration, apoptosis, or necrosis or hemodynamically as transient or permanent cardiac contractile dysfunction, is a frequent consequence of physical myocardial trauma (cardiac contusion), cardiomyopathy, metabolic or toxic myocardial damage (anthracyclines, catecholamines, bacterial endotoxins, tumor necrosis factor), myocardial ischemia or infarction. However, early diagnosis of myocardial injury may be important from a therapeutic and prognostic perspective.
КОНТРОЛЬ ГЕНЕТИЧНО МОДИФІКОВАНИХ РОСЛИН – ГАРАНТІЯ ПРОДОВОЛЬЧОЇ БЕЗПЕКИ
Authors: Kushnir G.V.
Published: October 2016

One of the problems in formation of mechanisms of development of environmentally safe environment is the proliferation of genetically modified organisms (GMOs). The use of genetic engineering in agriculture, food and agricultural industry have created the new opportunities for manufacturing the food and feed for meet the ever growing needs of the world's population. However, the opinions of scientists about the benefits and risks of genetic engineering is different. So today is particularly acute issue unpredictable consequences and danger for human health and the environment which are connected with GMO.The article present the results of determination of genetically modified organisms in plant material for the period 2013 – 2015 years, from the farms of different ownership forms. Analysis of the conducted research indicates on the circulation in farms of Lviv region transgenic plants.Found that the most common genetically modified plants were maize, soya and rape. The research of plant material on the presence of GMOs was performed by polymerase chain reaction in real time (PCR RF) by setting in them target sequences of promoter 35S virus of cauliflower mosaic (CaMV), promoter of FMV and (or) terminator NOS (T–NOS) T1 plasmid of Agrobacterium tumefaciens, Pat, EPSPS, Cry 3A, and determined species identification of positive samples. The use of PCR–RF allows quickly and qualitatively detect the GMO in the research samples. In 2013, the percentage of positive samples was 3.9% of the total, in 2014 – 2.3% and in 2015 – 3.3%. It is therefore necessary to monitor the vegetable raw and seed material on the presence of genetically modified organisms, to monitor the situation on GMO in Ukraine, because the problem of biosafety and the evaluation of the potential risks from their use is not studied.
АКТИВНІСТЬ АМІНОТРАНСФЕРАЗ У СИРОВАТЦІ КРОВІ ТЕЛЯТ ЗА ДІЇ ПІРИДОКСИНУ ГІДРОХЛОРИДУ
Authors: Yaremko O.V. , Pelenio R.A.
Published: October 2016

The influence of pyridoxine hydrochloride (vitamin B6) activity in serum aminotransferases in dairy calves growing period (1 to 90 days). Calves control group received basic diet, but research from the first days of life to the basic diet added pyridoxine hydrochloride doses: I group – 1.0; II – 2.0; III – 3.0; IV – 4.0 V and group – 5.0 mg / kg body weight. Blood for the study was before the morning feeding at 1, 5, 21, 60 and 90 days after birth. Research aminotransferase activity was determined by the content of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and the ratio between them using factor where Ritisa.It was established that the addition of colostrum to milk and pyridoxine hydrochloride leads to increased aminotransferase activity. The low activity of AST and ALT in blood serum of calves of all groups was on the first day of life. Effects of pyridoxine hydrochloride on aminotransferase activity was shown during the research period. Adding to the colostrum vitamin B6 increases the activity of AST by 10 percent or more doses of only 3.0, 4.0 and 5.0 mg/kg body weight. Probably higher AST activity detected in animals II, III, IV and V groups at 21 and 60 days. On the 90th day of the experiment AST activity in serum of calves research groups stabilized, which may indicate the ability of vitamin B6 stimulate the growth and development of microorganisms scar. Adding to the colostrum and milk pyridoxine hydrochloride led to growth within the physiological norm ALT activity. Significant difference between ALT control and experimental groups established in calves III, IV and V groups 21, 60 and 90 day experiment, calves and the second group on day 90 of the experiment. Stabilization of enzyme activity investigated is set to 21 days in calves group IV, 60 – the third group and 90 days in calves second group. The ratio of AST to ALT (coefficient de Ritis) do not go beyond the physiological norm. For correction of vitamin–supply calves 1–21 days old is the optimal dose of daily supplement intake of calves 4 mg / kg body weight of vitamin B6 for calves with 21–60–day age – 3 mg / kg and 60 calves 90–day age – 2 mg / kg body weight.
ФАРМАКО–ТОКСИКОЛОГІЧНА ОЦІНКА ПРЕПАРАТУ «ЦИФЛУР»
Authors: Nagorna L.V.
Published: October 2016

The results of pharmaco–toxicological evaluation insectoacaricid preparation «Tsiflur», in particular the study of locally irritating effect of the drug on the skin and mucous membranes of rabbits eyes. The preparation «Tsiflur» – representative of synth pyrethroids, in its composition has the active ingredient cyfluthrin, production NPF «Brovafarma». According to the manufacturer's instructions, the preparation recommended for the control of flying midges and other representatives akaroentomofauny that have veterinary importance. The tool is a clear oily solution of a yellowish color.Experimental studies were conducted on rabbits analogues in several stages. In the first phase we studied local irritant effect of the preparation in varying degrees of dilution when applied to intact skin of rabbits. The aim of the second stage of the research was to determine the local irritant effect of the d preparation on the mucous membrane of the eyes of rabbits.It has been established that the preparation «Tsiflur» in the test concentration (1: 100, 1: 200, 1: 400 concentrate solution) during the observation period did not show locally irritating effects in a single application to the intact areas of the skin of rabbits. Monitoring the bellies of the experiment showed no redness, swelling, thickening of the skin folds and the pain response to palpation place application of the preparation. Not set also signs of toxic effects of native preparation «Tsiflur», when applied under similar conditions. The reaction of the skin of animals per application experimental preparation was valued at 0 points. In the study of the preparation in a similar concentration on the possibility of providing local irritant effect on the mucous membrane of the eyes of rabbits determined that the native application of the preparation led to the emergence of a slight reddening of the eye mucosa and the appearance of watery eyes. These symptoms disappear without any intervention on the second day of the experiment. The reaction to the introduction of the preparation «Tsiflur» was estimated at 1 point, for each identified symptom.
EPIDEMIOLOGICAL STUDIES TOWARDS CATTLE BABESIOSIS – TICK–BORNE DISEASE
Authors: Staniec M. , Buczek K. , Milczak A. , Adaszek Ł. , Winiarczyk S.
Published: October 2016

Cattle babesiosis is a dangerous and economically important tick–borne disease caused by hemoprotozoan parasites of the genus Babesia. The vector of the disease are ticks from Ixodidae family. Symptoms of disease are fever, anorexia, lethargy, anemia, jaundice and hemoglobinuria.The purpose of this study was to investigate prevalence of Babesia spp. in cattle in Lublin region. The PCR technique revealed the presence of 18S RNA Babesia spp. genetic material in the blood of 20 from 192 examined animals (10.4%). Our study showed that the bovine babesiosis occur in Poland with asymptomatic form and does not reduce milk production significantly. The diagnosis depends only on the basis of detection of the genetic material of parasite, and the direct microscopic examination of blood smears is not useful in the identification of Babesia spp. in erythrocytes.The comparison of PCR products showed low homology level between isolates with present study and other Babesia sequences obtained around the world.Moreover, the study showed the prevalence of piroplasms in ticks from Lublin region is low (0,63%).
Ages past: Ancient geology and modern preconceptions
Authors: Jordan J. M.
Published: October 2016

In many accounts of the history of the earth sciences, geology is identified as beginning in the seventeenth century against a backdrop of religious superstition and ignorance. A leading figure in those histories was James Hutton (1726–1797) who is credited with formulating the idea of ‘deep time’ based on his own observations of the rock cycle punctuated by unconformities. In his writings, and in many later history accounts, the contributions of classical thinkers are largely ignored. Although several contemporary historians of geoscience have commented already on the modernity of classical thinkers, the purpose of this paper is to document that classical awareness of deep time was more pervasive than is generally acknowledged. This paper argues that geology was, all told, one of the most advanced sciences in classical antiquity and enjoys a remarkable conversance with its modern successor. Classical naturalists and philosophers made scientifically valid observations and interpretations of many geologic processes including volcanism, sedimentation, hydrology, tsunamis, and fossil beds. Consequently, classical naturalists and philosophers should be considered worthy antecedents of modern geologists.
Electrical earthquakes: A short-lived theory in the 18th century
Authors: Poirier Jean-Paul
Published: October 2016

As soon as it was shown that thunderstorms were due to electricity, it became obvious for many physicists that earthquakes, which, as Pliny said, were subterranean thunderstorms, must be electrical phenomena. Despite some opposition, the ‘system of electricity’ became the fashionable theory of earthquakes, in the second half of the 18th century. Its proponents insisted on the idea that only electrical discharges could explain that earthquake shocks propagated instantaneously over large distances. A majority of the Italian philosophers attributed the disastrous 1783 Calabrian earthquake to electricity. When electrostatic machines and Leiden jars gave way to Voltaic piles, in the beginning of the 19th century, the ‘system of electricity’ rapidly disappeared.
The Implementation of Patient-Reported Outcome Measures in Yoga Therapy
Authors: Ross Alyson , Birdee Gurjeet , Touchton-Leonard Katharine , Bevans Margaret
Published: October 2016

Yoga therapists are interested in knowing whether their therapeutic interventions are helpful in improving health and wellbeing in their yoga therapy clients. However, few yoga therapists use standardized, reliable, and valid questionnaires to determine the therapeutic effectiveness of their treatments. Patient-reported outcome (PRO) measures are paper or web-based questionnaires used to assess an individual's perceptions of their symptoms and/or quality of life. In 2004, the National Institutes of Health (NIH) launched the PROMIS® initiative to standardize and simplify the collection of PROs in research and in clinical practice. The PROMIS® initiative launched a multicenter cooperative group that collected and reviewed thousands of PROs, then extensively tested them in over 20,000 research participants. The result was a web-based collection of item banks of the best questions or “items” within three domains of interest: physical, mental, and social health. These item banks are housed in the Assessment Center, a free online resource for collecting PROs.1

Incorporating PROMIS® outcomes into yoga therapy streamlines and optimizes the collection of PROs by enabling access to reliable and valid questionnaires that are easy to read, simple to complete, and are available in multiple languages as well as in both adult and pediatric versions. The use of standardized PROs may improve yoga therapy implementation in healthcare and accelerate translation of clinical research by allowing yoga therapists to conduct indepth symptom assessments using tools that allow for comparisons to other therapeutic clinical and research interventions.

The purpose of this paper is to summarize the development of the NIH PROMIS® initiative and to provide suggestions for incorporating PRO collection into yoga therapy. Important considerations to consider when implementing PROs into yoga therapy are discussed, including the choice of questionnaires and method of delivery (paper or web-based), frequency of PRO administration, interpretation and management of PRO results, and the management of problematic issues that arise.
Feasibility of a Brief Yoga Intervention for Improving Acute Pain and Distress Post Gynecologic Surgery
Authors: Sohl Stephanie J. , Avis Nancy E. , Stanbery Kimberly , Tooze Janet A. , Moormann Kelly , Danhauer Suzanne C.
Published: October 2016

Background: Women undergoing surgical procedures for suspected gynecologic malignancies frequently experience pain and psychological distress related to surgery. Yoga may reduce these negative surgical outcomes. The primary objective of this pilot study was to assess the feasibility of evaluating a perioperative brief Yoga Skills Training (YST) in this population. Secondary objectives were to (1) assess the immediate effects of the YST on pain and psychological distress; and (2) provide preliminary data for future studies. Method: Adult women scheduled to undergo an exploratory laparotomy for a suspected gynecologic malignancy were recruited to this one-arm feasibility study. Each woman received the YST, which consisted of three 15-minute sessions, one before and two after surgery. The following constructs were assessed: feasibility (rates of accrual, intervention adherence, measure completion, retention, and level of satisfaction), immediate effects of the YST (visual analogue scale ratings of pain and distress immediately before and after each session), and descriptive statistics for measures to be used in future studies. Results: Of the 33 eligible women, 18 were approached and 10 agreed to participate (mean age = 54.7 years; 90% White). Two women discontinued the study prior to starting the YST sessions. Of the eight participants who received the YST, five completed the pre-surgery session (63%) and seven completed (88%) both post-surgical sessions; one woman withdrew after one YST session. Participants reported high satisfaction with the YST. Acute pain and distress decreased from before to immediately after the YST session with moderate to large effects: pain, d's = −0.67 to −0.95; distress, d's = −0.66 to −1.08. Conclusions: This study demonstrated reasonable indicators of feasibility. In addition, patients showed short-term reductions in pain and distress. Next steps include attention to improving staff availability and intervention implementation in order to feasibly evaluate the perioperative YST, which shows promise for reducing postoperative pain and distress.
A Case Series on the Effects of Kripalu Yoga for Generalized Anxiety Disorder
Authors: Morgan Jessica R. , Sullivan Marlysa , Masuda Akihiko , Tully Erin , Cohen Lindsey L. , Anderson Page L.
Published: October 2016

Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder associated with substantial impairment and poor treatment response. Yoga influences processes that are linked to the maintenance of GAD including mindfulness, anxiety, and heart rate variability, but has yet to be evaluated among people with the disorder. The present study is a first step toward documenting the efficacy of yoga for reducing worry among people with GAD using a single-subject AB design case series and daily ratings of worry. Standardized self-report measures of worry, trait anxiety, experiential avoidance, mindfulness, and heart rate variability were assessed pre- and post-intervention. Three participants with primary GAD received eight twice-weekly Kripalu yoga sessions following a baseline data collection period. All participants showed systematic improvement in daily worry ratings on at least one index and all scores on self-reported measures of worry, anxiety, experiential avoidance, and mindfulness changed in the expected direction following yoga (with one or two exceptions). Participants also showed improved heart rate variability during a worry period from pre- to post-intervention. Yoga has the potential to improve the processes linked to GAD and should stimulate further research in this area.
INTERRELATION BETWEEN EARLY TRAUMATIC EXPERIENCES AND DISSOCIATION PROCESS AMONG ALCOHOL-DEPENDENT PATIENTS
Authors: Shytov E A , Shustov D I
Published: October 2016

Dissociation is commonly conceptualized as a psychological defense mechanism that develops as a reaction to overwhelming traumatic experiences, especially childhood trauma. The article presents the results of our own research on the interrelation between early traumatic experiences, time of substance using and dissociation in alcohol-dependent male patients. The results of the research prove the interdependence of dissociation process and early traumatic experiences. The interrelation between time of alcohol abuse and dissociation were not discovered
Our experience in videoimage endoscope nephropexy
Authors: Lobanov D V , Aristarkhov V G , Kirilov J B , Butskikh A N
Published: October 2016

The article is devoted to the surgeon technology of videoimage endoscope way of treatment of nephropexy and postoperative looking after patients
The combination of revasculizative (остеотрепанации) with other operative interference of patients with obliterating atherosclerosis of arteries of lower extremity
Authors: Egorov A A , Suchkov I A
Published: October 2016

The main problem at reconstructive interference in vessels of patients with obliterating atherosclerosis of lower extremity arteries (OAALE) is the restriction of outflow because of many level involvements. The revasculizative (остеотрепанация) of a shin is the alternative of amputation of the extremity. We suggest to have the combinations of revasculizative (остеотрепанации) of a shin with reconstructive operations on arteries of lower extremities and also in combination with lumber sympathicomy and roentgenoendovascular dilatations. (RED).
TO THE PROBLEM OF DEVELOPMENT OF CULTURAL AND EDUCATIONAL ASPECT IN THE MEDICO'S PERSONALITY FORMATION
Authors: Tararyshkina М А
Published: October 2016

The conception of development of cultural and educational aspect in the course of medical training is formulated in the article. The basic components of the aspect are singled out, namely medico and pedagogical tact, cultural and moral education, the stirring up of self-education, moral and deontological behaviour. A pattern of cultural and educational aspect is offered, the conditions and methods of goal achievement are defined.
The particular features of the infiltrative tuberculosis in contemporary conditions on an example of a case from clinical practice
Authors: Chugunova G N , Karavaev N S , Medvedeva L I , Bogdanova T B , Makarjeva N N
Published: October 2016

Today the aim of the doctors of the dispensary - clinic section is to identify TB patients as early as it is possible in different layers of the society including social non adapted groups and risk groups, because the struggle with tuberculosis is one of the most important problems of public health service. Nowadays, taking into account the ысфду of migration, we must carefully examine persons who come from the areas where epidemic can break, when we give them medical certificates. Later they should be under cliose observation as persons of the risk group.
Some clinical phenotypical peculiarities of children with anomaly situated chords in the left ventricular cavity
Authors: Tsvetkova I V , Dmitrieva H V , Gomenjuk O B
Published: October 2016

The present research was aimed at identification of out of heart markers of dysplasia of connective tissue in children of school age with anomaly situated chords in the left ventricular cavity. We discuss the influence of the spread of out of heart effects of dysplasia of connective tissue upon the formation of the clinical picture in the above mentioned group.