bluuebunny/crossref_metadata_2025 huggingface dataset:
A memória redesenhada: aspectos extrapatrimoniais do Corredor Cultural andreense
Authors: Candido de Souza Leandro
Published: August 2018

O presente artigo tem como objetivo analisar alguns aspectos da patrimonialização dos bens que constituem o chamado Corredor Cultural do município de Santo André, observando particularmente a reorganização da identidade municipal que ele implica. Em um primeiro momento, tentaremos fornecer elementos historiográficos para a leitura de como determinados bens interagem com os registros da memória pública regional e quais são suas implicações na reescrita do espaço urbano local. Em um segundo momento, discutiremos como esse Corredor tenta solucionar uma crise na elaboração da memória andreense, provocada pelo esgotamento do modelo de modernização implantado na região – a partir do golpe militar de 1964 – e os padrões intelectuais que esse modelo consagrou.
Study of Cascaded H-Bridge Converter Control Strategies and their Impact on Switching Harmonics
Authors: Rashmi Vidya , Khare Manju
Published: August 2018

The Cascaded H-Bridge (CHB) multilevel static synchronous compensator (STATCOM) has been widely accepted in the industry [1]-[8]. An outstanding advantage of the CHB multilevel topology is their modular structure. This enables higher-level STATCOM to be easily implemented through series connection of more cells. since the pulse-width modulation (PWM) signals of each cell are generated all by the central controller instead of their own controller, the cell does not look like an “independent module”. To achieve “true” modular implementation, a distributed control system (DCS) for the CHB multilevel STATCOM should be developed.
Improving Students` Critical Thinking Through E-Book on Project-Based Learning in Vocational High School
Authors: Fitri Rahmawati Marini , Siswandari Siswandari , Hakim Lukman
Published: August 2018

This study aims to describe the use of e-book based on project based learning in improving students' critical thinking in inventory materials in VHS. This type of research is a quantitative descriptive study with a case study method. The sample of this research used 30 students in SMK Batik 1 Surakarta. The sampling technique uses simple random sampling technique, while the data collection technique used is essay test. The essay question is made in accordance with the indicators of critical thinking, namely analyzing, evaluating, and creating. The results showed that before using e-book based on project based learning only 8.3% of students were able to analyze, 50% evaluate, and 40% created. However, after using the e-book, students who were able to analyze increased to 55%, evaluated 93.3%, and created 76.7%. any as 10% have enough critical thinking. So, the use of e-book based on Project Based Learning can increase students' critical thinking.
Consolidating peace: Rethinking the community relations model in Northern Ireland
Authors: Knox Colin , McCrory Seamus
Published: August 2018

Northern Ireland has now moved from ‘negative’ peace (the absence of violence, largely) to ‘positive’ peace (confidence-building measures to consolidate gains in voting practice and in reducing discrimination against the minority community in employment and housing allocation). This transition has involved funders at the European, regional and local levels investing in peace and reconciliation measures to consolidate political gains made since the Belfast (Good Friday) Agreement in 1998. This paper examines the achievements made to date, the extent to which they have resulted in a peace dividend for those most impacted by the violence, and whether the focus of peace-building interventions should shift away from the traditional community relations model. It finds that the reformed local authorities in Northern Ireland and the border regions could play a pivotal role in making a significant difference to peace-building through new legal powers in community planning.
Gendering the institutional legacies of the Northern Ireland senior civil service
Authors: Rouse Michelle
Published: August 2018

The adverse gender outcomes associated with post-conflict power-sharing arrangements contrast starkly with the socially transformative promise of the framework peace agreements which produce them. Scholarship that has sought to analyse the adverse gender outcomes which occur on imple - mentation has largely focused on the complexities of power-sharing institutional architecture and the role of elite political actors within it. This article makes the case for a new research direction. Parallel research in the field of post-conflict public administration indicates that the complexity of power-sharing institutional arrangements may provide increased opportunity structures for the use of bureaucratic discretion. While use of bureaucratic discretion among elite bureaucrats in Northern Ireland was found to be grounded in core public service values (O’Connor, 2015), feminist institutional analysis exposes those ostensibly benign values (neutrality, objectivity and impartiality) as distinctly gendered phenomena when mediated through the prism of gendered organisational culture (Chappell, 2002, 2006). This article considers the history and specificity of the Northern Ireland civil service and in particular its elite cohort of decision-makers - the senior civil service (SCS) - with a view to excavating the particular institutional legacies which may imbue SCS values and culture. In doing so it asks whether gendered institutional legacies have the potential to function as structural inhibitors to formal provisions for gender equality and socially transformative policy in Northern Ireland’s post-conflict dispensation.
The Modulation Of Detrusor Contractility By Agents Influencing Ion Channel Activity
Authors: Kocmálová M. , Ľupták J. , Barboríková J. , Kazimierová I. , Grendár M. , Šutovský J.
Published: August 2018

Background: This study specified the role of several significant ion channels regulating the metabolism of calcium ions in contraction and relaxation of human detrusor muscle in order to identify possible target for future drugs that are capable of treating diseases resulting from impaired detrusor activity, e.g. overactive bladder. Although this disease can be successfully treated with muscarinic receptor antagonists or β3 agonist, many patients may not be suitable for chronic therapy, especially due to the relatively high side effects of the treatment.

Material and Methods: The study used the isolated detrusor tissue samples, which were obtained from the macroscopic healthy tissue of urinary bladder from 19 patients undergoing a total prostatectomy because of localized prostate cancer. Each biological sample was prepared into 8 strips. We used oxybutynin and mirabegron as control drugs and several blockers of specific subtypes calcium and potassium ion channels as tested substances. The contractility of bladder was investigated by an organ tissue bath method in vitro and contraction was induced by carbachol.

Results: The amplitude of contraction was successfully decreased by positive control drugs and, from tested agents, the comparable effect had the substance capable of influencing IP3 receptors and Orai-STIM channels and combination consisting of drugs possessing an inhibitory effect on IP3 receptors, L- and T-type voltage-gated calcium channels and Orai-STIM channels.

Conclusion: The present work represents a new finding about handling Ca2+ in urinary bladder contraction and pointed to a dominant role of IP3 receptor-mediated pathway in the regulation of Ca2+ metabolism, which may represent a future strategy in pharmacotherapy of impaired detrusor activity.
Possibilities of quantitative and qualitative inventory of drainage devices based on selected maps and photogrammetric images
Authors: Kraczkowska Karolina , Stachowski Piotr
Published: August 2018

The aim of the work was to analyse which of the selected geodetic and cartographic materials (maps and high resolution aerial images) are useful for inventory of water drainage devices. Obviously, correct determination of their quantitative and qualitative statuses can be made through field inventory. Quantitative inventory can also be done on the basis of maps. For the purpose of this research, an analysis was carried out which consisted of checking which of the selected cartographic and photogrammetric materials best reflect the location of irrigation devices in the field. The analyses were based on both digital and analogue maps at the scale of 1 : 50 000 to 1 : 5 000. The selected photogrammetric materials included images at the scale of 1 : 10 000 and 1 : 1000.
The impact assessment of different fee systems on the municipal waste management effectiveness
Authors: Báreková Anna , Kondrlová Elena
Published: August 2018

The most widespread monetary motivation in the municipal waste management is a pay-as-you-throw (PAYT) or unit-based pricing scheme when fees are directly based on the volume of waste produced by a household. This approach forces the households to carry the full social costs of their waste disposal decisions, inducing more efficient choices. Volume-based schemes usually require households to purchase waste bags or stickers (tokens) that they can attach to their waste containers. The aim of our research was to assess the waste management system in the municipality of Dolný Ohaj, where different payment systems for municipal solid waste (MSW) charges were introduced during the monitored period (2012-2016). While a lump sum had been used in the municipality up to the end of 2014, a volume-based scheme in a form of the token system was introduced and applied in the municipality from the beginning of 2015 onwards. The main focus was to analyse the waste management of the municipality during the studied period 2012-2016 with the emphasis on municipal solid waste fees, the generation of MSW and residual fraction, municipal waste management revenues and expenditures as well as evaluation of economic results. The production of MSW in kilograms per person had decreasing tendency during the monitored period. The highest MSW production was observed in 2012 (262.68 kg.capita-1.year-1) and the lowest in 2016 (175.85 kg.capita-1.year-1). During the monitored period, also the amount of landfilled residual waste was decreasing. In 2016, the lowest quantity of landfilled MSW (237,150 kg) was recorded. The municipality reached noticeably better economic results in waste management during the period under the volume-based waste collection scheme.
The role of DPSIR Diagram in the analysis of Ecological and Social conditi ons of the Aral Sea shrinking problem in Uzbekist an
Authors: Reimov M. , Húska Dušan , Pulatov Alim
Published: August 2018

The paper deals with application of the DPSIR diagram approach to the Aral Sea ecosystem problem. The DPSIR diagram, a causal framework for environment-society interaction, represents complex connections between the shrinking of the Aral Sea and various social and ecological problems in the region. Examining the components of this interdisciplinary approach - economic forces, pressures, states, impacts and responses could lead to a common response to the environmental, social and economic challenges in the Aral Sea region.
Potential of Short Food Supply Chains, their Role and Support within the Rural Development Policy in the Slovak Republic
Authors: Floriš Norbert , Schwarcz Pavol
Published: August 2018

Absract

Current unfavourable situation in agricultural sector of the Slovak Republic makes national public authorities to look for possible solutions for satisfaction of local producers and consumers as well. Increase of domestic production in the programming period 2014-2020 with focus especially on producing high quality products is a challenge for Slovak government and local producers, too. In this paper we reveal the theoretical determination, legal limitations, opportunities for support and the level of implementation of short food supply chains as a tool for farmers, producers and processors to increase the added value of their products through promotion of existing and creation of new local markets. The possible support is described both in terms of the rural development policy as well as the regional policy, under limitations defined in European and national legal documents. The level of implementation of short food supply chains in agricultural sector of the SR is described in relation to the Rural Development Programme of the Slovak Republic 2014-2020.
Dynamics of Financial Development, Economic Growth, and Poverty Alleviation: The Indonesian Experience
Authors: Dewi Sovia , Abd. Majid M. Shabri , Aliasuddin  , Kassim Salina
Published: August 2018

Although the poverty rate in Indonesia has been declining in the last several years, the rate of poverty decline is slowing down. In order to achieve its poverty reduction target within the stipulated time period, the government has stepped up efforts to enhance the contribution of the financial sector towards poverty reduction. This study aims to empirically explore the interlinkages between financial sector development and poverty reduction in Indonesia. Focusing on annual data covering the period from 1980 to 2015, the study adopts the Autoregressive Distributed Lag (ARDL) cointegration approach to examine the long-run relationship between the variables. The study found that there is a long-run relationship between financial development, economic growth, and poverty reduction in Indonesia. It also documented a unidirectional causality running from the financial sector to poverty reduction and a bidirectional causality between economic growth and poverty reduction. Therefore, policies to ensure the conducive growth of the financial sector would go a long way in promoting the economy, creating employment opportunities, and consequently accelerating poverty eradication
Institutions and Firms’ Performance in Transition Countries: The Case of Selected Cesee Countries
Authors: Aralica Zoran , Svilokos Tonci , Bacic Katarina
Published: August 2018

Institutional reforms in the countries of Central Eastern and South Eastern Europe (CESEE) brought about a redefinition of the role of the state, the market and the business sector. We assess the effects of various dimensions of the institutional environment on the labour productivity of manufacturing firms in selected CESEE countries by employing a multilevel model. Our findings reveal that the curbing of corruption and the provision of inter-industrial externalities through the development of a commercial and professional infrastructure have beneficial effects on firm productivity. At the same time, a stricter political and legal framework and the provision of R&D infrastructure have an adverse effect. Such a finding is typical for producers of standardised products in countries with low levels of legal framework development for which R&D and legal adjustments incur cost disadvantages. The implication is that institutional development should be accompanied by a strengthening of firms’ absorptive capacity in order for businesses to benefit from such changes
Engaging with Patients In-need through Public Health Partnerships
Authors: Nuffer Wesley , Trujillo Tara , Harmon Christy , Thompson Megan
Published: August 2018

A public health partnership was established between a state Medicare Regional Care Collaborative Organization (RCCO), the state health department, a pharmacy school and three community pharmacies located in rural Colorado to optimize the utilization of a free public health service provided through each pharmacy.  Fourth-year pharmacy students were allocated year-round by the University of Colorado to support disease management and medication therapy management (MTM) services offered to patients in three rural towns served by the RCCO.  Faculty from the school of pharmacy reviewed data provided by the RCCO to identify patients who could benefit from MTM or disease state management (DSM) services.  These patients were contacted and encouraged to take advantage of these free pharmacy-based services.  Additionally, a number of targeted interventions were performed within these populations to optimize their health.  Concerted efforts were made to improve information flow and communication between these pharmacy sites and partnering medical offices.  Additionally, pharmacy students were successfully integrated in to medical offices to work alongside medical providers in these communities.  This manuscript describes the implementation and coordination of this project as well as the impact these pharmacies had on the communities they served.

 

Topic: Original Research
The Optimazing Used of Rainwater Harvesting on Flats as an Effort to Reveal Eco-Architecture
Authors: Handoko Jarwa Prasetya S.
Published: August 2018

Clean water supply for urban residents is very important. The issues related to
clean water are raising in line with the development of cities as it is happened in Yogyakarta. Yogyakarta is one of the major cities with high population growth in Indonesia. This leads to the increased demand of community housing. The
Government of Yogyakarta is continiously addressing the needs of urban settelements by building flats as one of the many ways to solve the related problems. The construction of settlement facilities should consider the availability of clean water. Thus, it is mandatory for the building contructors to provide a large available capacity of clean water for the residents to solve urban water crisis problems. The concept of rainwater harvesting is a concept intending to save the use and the management of water supply to meet the needs of the building. This concept provides an alternative source of clean water by utilizing rainwater. Therefore, it is necessary to evaluate the effectiveness of rainwater harvesting used in flats building towards the reduction of clean water needs. This is an explorative comparative study on flats building design and flats clean water needs of two flats in Yogyakarta. This study is to provide a general description of the potential use of the concept of rainwater harvesting in building flats to reduce clean water requirements of a building. It is concluded that the potential use of rainwater (rainwater harvesting) on building flats could reduce the need for cleanwater of its inhabitants. This will reduce the energy requirements in the provision of cleanwater in the buildings. It is also recommended that the design of the buildings should integrate the concept of rainwater harvesting as a way in developing an eco architecture building.
Keywords: Clean water needs, Rain-water harvesting, Flats, Eco-architecture
Creating Space for A Better Life
Authors: Soegijoko Budhy Tjahjati S.
Published: August 2018

A United Nation Habitat Report “State of the world Cities 2010/2011”, mentioned that the world is increasingly becoming urban. By 2050, urban population in the developed and developing region will reach 86% and 67% respectively of their total population. By the year 2030, in all developing countries – including Asia and Africa there will be more people living in urban than in rural areas. Cities, large or small, city centers, sub urban or per urban, offer people the opportunity to share the urban space, participate in public and private events, exercise both duties and rights.

From discussion of the different cities and their characteristics and requirement for sustainability, lessons learned to be used as basis for identifying policies in the future, the way forward, key lessons learned among others are the need to:
− Plan long term
− Build good quality infrastructure
− Be prepared to make major changes in response to new challenges, and
− City policy makes and leaders should involve citizens
− Main areas for improvement and intervention include:
− City’s environmental quality
− Neighborhood amenity
− Individual well being
The way forward, indicate that it is important to first, focus on approach that concentrate on implementation of development of physical, social environmental infrastructure, and establishing enabling frameworks.
Second, it is imperative to maintain balance between economic, environmental and social development to reach sustainability.
Third, it needs to be supported by capacity building to improve and implement urban management with finance.
Sustainability Lesson from Southeast Asia: Singapore Experience
Authors: Widodo Johannes
Published: August 2018

To inaugurate the birth of International Journal on Livable Space (LivaS) it is proper to remind ourselves that livability requires holistic approach, strong vision, sustainable practice, and resilience. This keynote article will outline a story of Singapore, a tiny island nation without natural resources, in its continuous struggle for survival from the past to the present and towards the future. It will discuss various examples on different scale levels (city planning, architecture, design ideas, conservation projects, environmental practices, etc.), and focusing on how our planning and design disciplines can contribute to tangible efforts to achieve environmental, cultural, and economic sustainability in holistic way. 
The Influence of Roof Cover Material on Gable Model to Climate Parameters - Case Study :RumahInstanSederhanaSehat (RISHA), PuslitbangPermukiman, Bandung
Authors: Renita Renita
Published: August 2018

A roof should be able to prevent and reduce the radiationheat.It is more recommended if it gives a good effect in both prevention and reduction of heat. Through this research, the author wanted to know the influence of the roof covering material to gable roof style towards the climate parameters, such as temperature of humidity and heat radiation. Gable roof style is considered as more effective rather than others traditional roof style. The ability of heat reduction and humidity performances of the gable roof was tested by using Asbestos, Roof Tiles, Metal deck, and Green Roof covering material to RumahInstanSederhanaSehat (RISHA) in Centre for Housing Research and Development (PuslitbangPermukiman), Bandung. The variations of ceiling and non-ceiling were applied for knowing the result specifically in terms of the level of humidity and temperature in the room. By using quantitative descriptive method, Metal deck gave the fastest effect towards the temperature reduction, while Roof Tiles gave the best effect by using ceiling, and Green Roof gave the best effect by not using ceiling. Humidity aspect that gave the best effect occurred when using ceiling, either when using ceiling or not. Meanwhile, the lowest humidity happened when using Asbestos and Green Roof material. In the ability to reduce heat radiation, Green Roof had the best ability in reducing the heat or had worst ability in heat radiation, followed by Metal deck. Meanwhile, Asbestos covering material had the best heat radiation ability.

Keywords: Roof Covering Material, Gable Roof Model, Climate (temperature, humidity, and heat radiation). 
PRELIMINARY STUDY: THE INFLUENCE OF MICRO CLIMATE ASPECTS TO MINIMALIST LANDED HOUSES AND A VERNACULAR STILT HOUSE (CASE STUDY: HARMONIA AND BELLAROSA CLUSTERS, KAMPUNG NAGA HOUSE, INDONESIA)
Authors: Asriningpuri Handajani
Published: August 2018

Today, minimalist building style is considered appropriate to the reasons of: the high price of land and materials. Moreover, vernacular style inspires designers to categorisize it as a simple architectural type that is responsive to the context of micro climate. Both are modest style as undecorated building. This study aimed to communicate research result on the influence of micro climate aspects to both mentioned architectural types.

Descriptive-analitic approach applied in this article is to identify the differencies between the features of minimalist landed houses (Harmonia and Bellarosa Clusters) and vernacular stilt house (Kampung Naga) components which are influenced by micro climate aspects. The result of study is that the decreasing and increasing of indoor temperature are determined by wall type and material; ventilation system; roof, eave and bottom structure types; geographical position; openings dimension.

Keyword: micro climate; minimalist; vernacular architecture.
THE TYPOLOGY OF TRADITIONAL HOUSE: BALE TANI IN SADE VILLAGE, LOMBOK, WEST NUSA TENGGARA
Authors: Mannan Khalid Abdul
Published: August 2018

The lack of knowledge of the present generation in understanding the cultural heritage of the ancestors as well as the socio-cultural changes is due to the advancement of tourism. This becomes a phenomenon that could result in the loss of local architectural knowledge, and the loss of cultural values as it is especially the case in the traditional house of Sade village. In an effort to explore the condition, this study on typology of traditional house, especially traditional house of Bale Tani in Sade village, Lombok, West Nusa Tenggara was conducted. In addition to socio- cultural factors, there are other factors that also affect the variety types of its forms such as climate, technology, land selection, availability of materials and construction method.

The research used qualitative method with naturalistic approach supported by literature and comparative study. The result of the research indicates that there has been a transformation process in the form of traditional house of Bale Tani but it is not dominant (it does not affect the visual form as a whole), it has slow progress (it happens within the long time span) and it happens on some parts/elements of Bale Tani only. Factors that influence the change are endogenous (understanding the cultural values by the Sade society) and exogenous factors that is the influence of social culture (tourism).

Keywords: Typology, traditional house, Bale Tani 
Dermatoscopic diagnostics of nevus sebaceous of Jadassohn
Authors: Zhuchkov M. V. , Bolshakova Е. E. , Sonin D. В. , Rodionova S. A.
Published: August 2018

Aim. The aim of this study was to examine the dermatoscopic signs of nevus sebaceous in its different age periods.Materials and methods. The study sample included 49 patients diagnosed with nevus sebaceus of Ja dassohn, seeking medical assistance in the Ryazan Region Clinical Dermatological and Venerealogical Dispensary during the 2014–2018 period. The age of the patients ranged from 1 month to 69 years.Results. The study describes the main dermatoscopic manifestations of nevus sebaceous of Jadassohn in its different age periods.Conclusions. The results of the study are significant for the differential diagnostics of nevus sebaceous of Jadassohn.
Ectopic pregnancy în rudimentary horn: early diagnosis and management
Authors: Petca Aida , Veduţa Alina , Claudia Mehedintu , Măru Nicoleta , Petca Răzvan , Boț Mihaela
Published: August 2018

Pregnancy in rudimentary horn is a rare clinical entity with an incidence ranging from 1:76.000 to 1:140.000 preg­nan­cies. The symptomatology that accompanies pregnancy de­ve­loped in rudimentary horn is similar to that of ectopic preg­nan­cies or may evolve as a normal pregnancy. It is dif­ficult to diagnose in the first trimester of pregnancy when conservative treatment is possible, with minimal mor­bi­di­ty, frequently evolving until the second trimester when clinically manifests as a uterine rupture syndrome and it is accompanied by intraperitoneal hemorrhage and he­mor­rhagic shock. It is desirable that the diagnosis of these pregnancies to be established as early as possible in the first trimester of pregnancy and they will be terminated as soon as they have been diagnosed with certainty.
Fetal growth restriction – recent developments
Authors: Petca Aida , Boț Mihaela , Zvâncă Mona Elena , Veduţa Alina
Published: August 2018

Important progress has recently been made in the under­standing, diagnosis and treatment of intrauterine fetal growth restriction (IUGR). In 2016, a consensus on the definition of IUGR was reached. Early IUGR (IUGR before 32 weeks of gestation) is a relatively rare but severe con­di­tion. The diagnosis of early IUGR is straightforward, but the therapeutic results are negatively influenced by severe prematurity. The prevalence of late IUGR (IUGR after 32 weeks of gestation) is not clearly known. The therapeutic results are good in the diagnosed cases of late IUGR, but the diagnosis of the condition in the general pregnant population is difficult.
Paracetamol during pregnancy: how safe is it?
Authors: Boț Mihaela , Tecuci Adriana , Petca Aida , Zvâncă Mona Elena , Vlădăreanu Simona
Published: August 2018

Acetaminophen (paracetamol) is the most commonly used analgesic and antipyretic during pregnancy. Research suggests that acetaminophen use in pregnancy is associated with abnormal fetal neurodevelopment (an increased risk for neurodevelopmental impairment − ADHD, autism and hyperactivity symptoms). Paracetamol causes language delay (less than 50 words at 30 months of age). Other recent studies describe the association of urogenital male malformations after prenatal paracetamol exposure.
Therapeutic implications of oxidative stress in squamous cervical neoplasia
Authors: Comănescu Maria  , Manda Gina , Potecă Anca , Brătilă Elvira , Mitran Mihai
Published: August 2018

Cervical cancer is one of the most common causes of cancer-associated mortality in women worldwide. Although neoplastic epithelial transformation and the association with HPV infection have been widely studied, there is less research on the effect of other factors, such as oxidative stress (ROS). To study the antioxidant status of the different steps in cervical cancer development, we analyzed 32 cervical samples. The histological spectrum of alterations varied from low grade intraepithelial lesions to invasive carcinoma. Formalin-fixed, paraffin-embedded 4-cm tissue sections were stained with various immunohistochemical antigens targeting both neoplastic epithelial cells and stromal component. The stromal response was heterogeneous and showed different patterns which were correlated with the epithelial alterations. Carcinogenesis integrates various landmarks into a pathological network of events and cellular responses under the influence of many types of stress – oxidative and inflammatory, which support tumorigenesis and tumor progression, but are also effective antitumoral therapeutic tools. Recent data showed that the chemo- and radiotherapy efficacy requires a tumor-activated oxidative status, suggesting that the pharmacological inhibition of the endogenous antioxidant system may represent an adjunctive therapeutic approach in solid tumors to control resistance to conventional anti-tumoral therapy.
Human Papilloma Virus – neonatal involvement
Authors: Popescu Simona , Bănică Andreea Mădălina , Vlădăreanu Simona , Vlădăreanu Radu
Published: August 2018

Aims . Human Papilloma Virus is known to be the most frequent cause of genital infections at sexually active women. The virus is transmitted mainly sexually but epidemiological and clinical data suggest sufficient evidence also for other routes of transmission. Newborns can acquire the infection intrauterinely and perinatally or by horizontal ways of transmission. We aimed to describe, by reviewing the literature, the damaging effect of HPV on pregnancy outcomes and the risk of the newborn to develop recurrent respiratory papillomatosis. Also, we assessed the risk of HPV bivalent and quadrivalent vaccine in pregnancy and paediatric population.
Method . We carried out an electronic database search, such as Pubmed, Medline, Google Scholar, for articles including “Human Papilloma Virus”, “perinatal transmission”, “recurrent respiratory papillomatosis”, “HPV vaccine”, “pregnancy outcomes”. We selected articles published between 2015 and 2018.
Conclusions . The main mode of transmission from mother to newborn occurs during pregnancy and at the time of delivery. The virus can also be transmitted among the family members by close contact. There is insufficient data to conclude about the impact of Human Papilloma Virus on pregnancy and on the newborn, so for a relevant understanding more research for a long term and with an extended cohort is needed.
Effects of alcohol use during pregnancy. Alcoholic fetal syndrome
Authors: Stan Daniela , Mitran Mihai
Published: August 2018

Often, pregnant women don’t realise the effects of alcohol use on the fetus. If the future mother drinks alcohol in the nine months of pregnancy, consequences on the fetal development can be extremely bad, leading to alcoholic fetal syndrome. Nowadays, as there doesn’t exist a method to determine the safe quantity of alcohol comsumption, doctors recommend that women should not drink any alcohol during pregnancy.
Redox–state Dependent Activation of Silanes and Ammonia with Reverse Polarity (PCcarbeneP)Ni Complexes: Electrophilic vs. Nucleophilic Carbenes
Authors: Piers Warren , LaPierre Etienne A. , Gendy Chris
Published: August 2018

A rigidified PCalkylP ligand allowed for the synthesis and charactarization of cationic and radical PCCarbeneP nickel complexes in which the carbene anchor of the pincer framework is electrophilic rather than nucleophilic. Alpha-hydride abstraction from (PCalkylP)nickel halide complex readily leads to the cationic carbene complex, which furnishes the radical carbene complex by one electron reduction. The reactivity of these reverse polarity carbene complexes towards small molecules (H2, CO, CO2, R3SiH, NH3) reveals different modes of activation when compared to previously reported nucleophilic nickel carbene complexes, and a clear dependence on the redox state of the complex. For H2, CO and CO2, no reaction is observed, but silanes react via hydride transfer and formation of solvated silylium ions. Ammonia is activated in a novel way, wherein it coordinates the carbene carbon and is deprotonated to form a robust C-N bond. This is not only a rare example of ammonia activation by a first row transition metal but also evidence of the intermediacy of group 10 carbenes in direct C-N bond forming reactions.
Re-Designing Hazardous Chemicals with Target-Specific Toxicities by Learning from Structure-Based Drug Design
Authors: Clymer Traci , Vargas Vanessa , Corcoran Eric , Kleinberg Robin , Kostal Jakub
Published: August 2018

Chemicals are the basis of our society and economy, yet many existing chemicals are known to have unintended adverse effects on human and environmental health. Testing all existing and new chemicals on animals is both economically and ethically unfeasible. In this paper, a new in silico framework is presented that affords redesign of existing hazardous chemicals in commerce based on specific molecular initiating events in their adverse outcomes pathways. Our approach is based on a successful methodology implemented in computational drug discovery, and promises to dramatically lower costs associated with new chemical development by synergistically addressing chemical function and safety at the design stage.
Bruno’S Organic universe and the natural magic
Authors: WANG Zheng
Published: August 2018

Giordano Bruno (1548 – 1600) is regarded as the principal representative of the infinite and homogenous universe. Bruno has a modern rational mind by no means. However, his doctrine has so deeply influenced the reconstruction of a modern understanding of the material of universe and human body. His process of rebuilding the cosmology and humanity consists in learning the individual’s psychical condition and the relations between society and man. The links between the components of the brunian organic universe can be generated spontaneously from “love-Eros” for the mundane life of its infinite expansion. And in his organic universe, Bruno considers and desires all beings to be alive, all to be animated. And from this doctrine, his predilection for the magic is derived, which is based precisely on the presupposition of a universal “panpsychism” aiming to take possession of the natural world with artifices.
Outlines of comparative view of Hindu and Christian Mysticism
Authors: ARION Alexandru-Corneliu
Published: August 2018

Mysticism is about knowing and unifying man with God (unio mystica), in a process that involves concerted cognitive and ascetic efforts. Mysticism does not follow, according to the classic pattern, the moralizing of man, but reach at the direct and immediate knowledge of God. Thus, mysticism is not, firstly, a matter of ethics, but a theoretical or, rather, an epistemological one. For what is being pursued and done in the states of ecstasy is a different kind of knowledge than the one allowed to people in the common state, knowledge which is also a special state of grace. Thus, in order to achieve the mystical state, Hinduism emphasizes true knowledge. The union with Brahman is given, but it must also be realized consciously through the salvific gnosis. The process of union in Hinduism is accomplished by removing the veil of ignorance (māya), that is, by knowing that the world is illusory, by the act of consciousness that man is essentially, always, identical to God. The knowledge (jñāna), obtained through meditative contemplation, is the path of mysticism in Hinduism. Once unity with God is given, it must only be consciously accomplished by removing the illusion that man would not be one with God-Brahman. The state of union is at the disposal of the ascetic, who has withdrawn from the world and lives only for contemplation. The model of Hindu ontological identity, Christianity opposes the model of personal transfiguration, through the continuous elongation of the person in God, realization possible only from the perspective of divine uncreated energies. God is not present with His being in the space that He created, but by plasticizing the reasons of creation, He constitutes the latter as an organic whole, harmonious in himself, which He sustains through His will. Unlike the ontological identity between God and the creature of Hindu perspective, the Christian mysticism of the Eastern Church postulates the eternally ontological difference between man and God
Taking Responsibility and the Manipulation Problem
Authors: DORANTES Roberto Parra
Published: August 2018

The main objective of this paper is to raise an objection against the analysis of the notion of ‘taking responsibility’ offered by John Martin Fischer and Mark Ravizza while developing their complex and attractive theory of moral responsibility. In this theory, there are two main requirements an agent must meet in order to be morally responsible for an action performed by her: first, the action must issue from a moderately reasons-responsive mechanism; second, the mechanism that leads to the action must be the agent’s own. This second requirement is explicitly intended to address some problems for the attribution of responsibility that arise in the context of certain cases of manipulation—what I will refer to as ‘the manipulation problem’. Fischer and Ravizza argue that this requirement (mechanism ownership) is satisfied when the agent has undergone the process of taking responsibility for that mechanism, and they spell out three conditions which, according to them, are jointly sufficient for taking responsibility. I will ultimately argue that this set of conditions fails to adequately address the manipulation problem because it either rules out certain cases of manipulation by mere stipulation or fiat (on one of two possible interpretations of these conditions), or is simply too weak to effectively rule out those same cases (on the alternative interpretation).
THE POLITICAL PERCEPTION OF YOUTH IN BANGLADESH
Authors: Tamanna Maheri
Published: August 2018

AbstractYouth in politics can be a creative force, a dynamic source of innovation which in turn brings positive changes in political systems. But today’s youth is neither deeply apathetic nor unconventionally engaged in mainstream politics due to its complex nature. This decreasing level of youth participation in politics not only endangers the quality of leadership but also jeopardizes the democracy of tomorrow. By using qualitative and quantitative data this study explored the trend of youth engagement and their disconnection with the current political systems. This study aimed to observe how the youth is unbundling the traditional concept of state power and identify the reasons for their non-engagement in politics which eventually challenges the political system of Bangladesh.
Foreign Experience of Import Substitution Policy
Authors: Baynov V. A.
Published: August 2018

In the current international environment — with fashion on international sanctions, in particular, limiting the possibilities of purchasing high-tech equipment from abroad and dependency of the exchange rate of the ruble against various political provocations — the Russian Federation has faced with the necessity of re-industrialization of the ‘raw’ model of the economy and stimulation of the development of its inner potential. It should be noted that, in accordance with the Plan for promoting import substitution in industry No. 1936-r of 30 September 2014, approved by the order of the Government of the Russian Federation, the Ministry of industry and trade of the Russian Federation has developed and is implementing 22 sectoral plans for import substitution in selected industries of the Russian Federation. In this regard, it is particularly important to study international experience in the field of import substitution policy. The validity and reliability of presented study are achieved by applying a systematic approach and scientific methods of analysis and synthesis, deduction and induction, as well as regulatory, empirical method, etc. As a result of the analysis of international experience, it was possible to identify measures that can improve the efficiency of the state policy of import substitution, including through the use of offset mechanisms in civilian industries and the development of the institution of public procurement, certification, and standardization. In conclusion, the author proposes measures that can improve the policy of import substitution. The practical significance of the article consists in the possibility of applying the results of the study in the elaboration of industrial development programs and further research.
Regulation of the Structure of the Insurance Portfolio as a Mechanism to Reduce the Risks of Insurance Companies
Authors: Larionov A. V.
Published: August 2018

The purpose of this article is to determine the influence of the portfolio structure on the stability of insurance companies’ activity. With this objective, we examined how the structure of insurance portfolio affects the risks of companies’ activity.

The author has proved that if insurance companies focus on voluntary property insurance it increases the probability of revocation of their licenses. These results were derived from a binary logistic regression using 112 observations. Parameters of insurance portfolio, as well as regional macroeconomic indicators that reflect the operating environment of the insurance business were used as variables for the model. Indicators of the insurance portfolio include voluntary and compulsory insurance. In the course of the research, it was revealed that one of the possible directions of development of insurance market regulation may be the organization of the mechanism of supervision over insurance companies, which allows soft impact on the structure of insurance portfolios in order to increase the stability of insurers. The introduction of this approach in regulation will allow the Bank of Russia to stimulate the development of the insurance market. Based on the results of the presented study, the Bank of Russia may develop guidelines to determine the optimal structure of the insurance portfolio. These recommendations can be one of the means of the surveillance policy over insurance companies. The orientation of the insurance company to certain types of insurance determines the stability of its functioning. In this regard, the Bank of Russia should develop an early warning system for disrupting the smooth functioning of the insurance company due to an incorrect focus on certain types of insurance.
Possible Solutions to the Problems of Microfinance Organizations with the Application of Intelligent Methods of Machine Learning
Authors: Zolotaryuk A. V. , Chechneva I. A.
Published: August 2018

The authors consider the problems associated with the activities of microfinance organizations, and directions to eliminate them. The subject of the study is the need to introduce machine learning to solve urgent problems. Machine learning methods are increasingly being implemented to analyze financial and economic information, which reduces and eliminates some of the difficulties. Although currently these methods are not widely used in the field of microfinance institutions (MFIs), there are opportunities for their application. The aim of the work is to determine the prospects for the use of these methods in MFOs. The article describes the subject area of research, associated with MFIs. The authors identify the main groups of problems related to MFOs, consider the possibility of introducing machine learning for data analysis in this area and determine the main directions of the possible use of machine learning for MFIs. The authors concluded that such methods are applicable for assessing the performance of MFIs.
Adaptation Strategies of the U.S. Companies to the Digitalization of Production
Authors: Bauer V. P. , Podvoisky G. L. , Kotova N. E.
Published: August 2018

The article considers one of the little-studied scientific problems — the problem of adaptation to digitalization in the sphere of production. This problem is investigated by the authors on the example of American companies. The researchers set themselves the task of analyzing various aspects of this problem — to identify the features and stages of adaptation of American companies in the implementation of digitalization in the field of production. The analysis of various scientific, analytical and expert sources allowed the authors to formulate not only the peculiarities of the processes of adaptation of American companies to digitalization in the field of production but also to identify the logic of the transition to the main levels of this adaptation from the lowest to the highest. The novelty and complexity of the problem of adaptation of the company in the process of informatization, according to the authors, significantly increases the role and responsibility of company managers, their ability to accept and actively contribute to new management practices. The study conducted by the authors showed that in the process of developing a strategy for the adaptation of American companies to digitalization in the field of production, various aspects should be taken into account, new technologies and management practices should be developed. The analysis of the problem allowed the authors to make significant progress in understanding the complexity of the adaptation processes of companies that start the process of digitalization.