bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Sources, Biological Functions, and Potential Applications of the Ubiquitous Marine Cyclic Dipeptide: A Concise Review of Cyclic Glycine-Proline
Authors: Hu Lei , Lin Jing , Qin Fei , Xu Li , Luo Lianzhong
Published: June 2024

Cyclic glycine-proline (cGP), a prevalent marine cyclic dipeptide, possesses a distinct pyrrolidine-2,5-dione scaffold, which contributes to the chemical diversity and broad bioactivities of cGP. The diverse sources from marine-related, endogenous biological, and synthetic pathways and the in vitro and in vivo activities of cGP are reviewed. The potential applications for cGP are also explored. In particular, the pivotal roles of cGP in regulating insulin-like growth factor-1 homeostasis, enhancing neuroprotective effects, and improving neurotrophic function in central nervous system diseases are described. The potential roles of this endogenous cyclic peptide in drug development and healthcare initiatives are also highlighted. This review underscores the significance of cGP as a fundamental building block in drug discovery with exceptional drug-like properties and safety. By elucidating the considerable value of cGP, this review aims to reignite interest in cGP-related research within marine medicinal chemistry and synthetic biology.
Green Seaweed Caulerpa racemosa as a Novel Non-Small Cell Lung Cancer Inhibitor in Overcoming Tyrosine Kinase Inhibitor Resistance: An Analysis Employing Network Pharmacology, Molecular Docking, and In Vitro Research
Authors: Lau Vincent , Nurkolis Fahrul , Park Moon Nyeo , Heriyanto Didik Setyo , Taslim Nurpudji Astuti , Tallei Trina Ekawati , Permatasari Happy Kurnia , Tjandrawinata Raymond R. , Moon Seungjoon , Kim Bonglee
Published: June 2024

The marine environment provides a rich source of distinct creatures containing potentially revolutionary bioactive chemicals. One of these organisms is Caulerpa racemosa, a type of green algae known as green seaweed, seagrapes, or green caviar. This organism stands out because it has great promise for use in medicine, especially in the study of cancer. Through the utilization of computational modeling (in silico) and cellular laboratory experiments (in vitro), the chemical components included in the green seaweed C. racemosa were effectively analyzed, uncovering its capability to treat non-small cell lung cancer (NSCLC). The study specifically emphasized blocking SRC, STAT3, PIK3CA, MAPK1, EGFR, and JAK1 using molecular docking and in vitro. These proteins play a crucial role in the EGFR Tyrosine Kinase Inhibitor Resistance pathway in NSCLC. The chemical Caulersin (C2) included in C. racemosa extract (CRE) has been identified as a potent and effective agent in fighting against non-small cell lung cancer (NSCLC), both in silico and in vitro. CRE and C2 showed a level of inhibition similar to that of osimertinib (positive control/NSCLC drug).
Las Bolitas Syndrome in Penaeus vannamei Hatcheries in Latin America
Authors: Intriago Pablo , Montiel Bolivar , Valarezo Mauricio , Romero Xavier , Arteaga Kelly , Cercado Nicole , Burgos Milena , Shinn Andrew P. , Montenegro Alejandra , Medina Andrés , Gallardo Jennifer
Published: June 2024

In September 2023, several hatcheries in Latin America experienced significant mortality rates, up to 90%, in zoea stage 2 of Penaeus vannamei. Observations of fresh mounts revealed structures resembling lipid droplets, similar to those seen in a condition known as “las bolitas syndrome”. Routine histopathological examinations identified detached cells and tissues in the digestive tracts of affected zoea, contrasting with the typical algal cell contents seen in healthy zoea. Polymerase chain reaction (PCR) testing for over 20 known shrimp pathogens indicated minimal differences between diseased and healthy batches. Both groups tested negative for acute hepatopancreatic necrosis disease (AHPND) but positive for Vibrio species and Rickettsia-like bacteria in the diseased samples. Histological analyses of the affected zoea revealed characteristic tissue degeneration in the hepatopancreas, forming spheres that eventually migrated into the upper gut, midgut, and midgut caeca, a pathology identified as bolitas syndrome (BS). Microbiological assessments revealed Vibrio species at concentrations of 106 CFU zoea/g in affected zoea, approximately two orders of magnitude higher than in healthy zoea. Bacterial isolation from both healthy and BS-affected zoea on thiosulphate–citrate–bile salts–sucrose (TCBS) agar and CHROMagar™ (Paris, France), followed by identification using API 20E, identified six strains of Vibrio alginolyticus. Despite similarities to “las bolitas syndrome” in fresh mounts, distinct histopathological differences were noted, particularly the presence of sloughed cells in the intestines and variations in hepatopancreatic lobes. This study highlights the critical need for further research to fully understand the etiology and pathology of bolitas syndrome in zoea stage 2 of P. vannamei to develop effective mitigation strategies for hatchery operations.
Monte Carlo Simulation of Quantum-Cutting Nanocrystals as the Luminophore in Luminescent Solar Concentrators
Authors: Nie Qi , Li Wenqing , Luo Xiao
Published: June 2024

Quantum-cutting luminescent solar concentrators (QC-LSCs) have great potential to serve as large-area solar windows. These QC nanocrystals can realize a photoluminescence quantum yield (PLQY) of as high as 200% with virtually zero self-absorption loss. Based on our previous work, we have constructed a Monte Carlo simulation model that is suitable to simulate the performance of the QC-LSCs, which can take into account the band-edge emissions and near-infrared emissions of the QC-materials. Under ideal PLQY conditions, CsPbClxBr3−x:Yb3+-based LSCs can reach 12% of the size-independent external quantum efficiency (ηext). Even if LSCs have a certain scattering factor, the CsPbClxBr3−x:Yb3+-based LSCs can still obtain an ηext exceeding 6% in the window size (>1 m2). The flux gain (FG) of the CsPbClxBr3−x:Yb3+-based LSC-PV system can reach 14 in the window size, which is a very encouraging result.
Transcriptome Analysis of Early Lateral Root Formation in Tomato
Authors: Zhang Aiai , Shang Qingmao
Published: June 2024

Lateral roots (LRs) receive signals from the inter-root environment and absorb water and nutrients from the soil. Auxin regulates LR formation, but the mechanism in tomato remains largely unknown. In this study, ‘Ailsa Craig‘ tomato LRs appeared on the third day and were unevenly distributed in primary roots. According to the location of LR occurrence, roots were divided into three equal parts: the shootward part of the root (RB), the middle part of the root (RM), and the tip part of the root (RT). Transverse sections of roots from days 1 to 6 revealed that the number of RB cells and the root diameter were significantly increased compared with RM and RT. Using roots from days 1 to 3, we carried out transcriptome sequencing analysis. Identified genes were classified into 16 co-expression clusters based on K-means, and genes in four associated clusters were highly expressed in RB. These four clusters (3, 5, 8, and 16) were enriched in cellulose metabolism, microtubule, and peptide metabolism pathways, all closely related to LR development. The four clusters contain numerous transcription factors linked to LR development including transcription factors of LATERAL ORGAN BOUNDRIES (LOB) and MADS-box families. Additionally, auxin-related genes GATA23, ARF7, LBD16, EXP, IAA4, IAA7, PIN1, PIN2, YUC3, and YUC4 were highly expressed in RB tissue. Free IAA content in 3 d RB was notably higher, reaching 3.3–5.5 ng/g, relative to RB in 1 d and 2 d. The LR number was promoted by 0.1 μM of exogenous IAA and inhibited by exogenous NPA. We analyzed the root cell state and auxin signaling module during LR formation. At a certain stage of pericycle cell development, LR initiation is regulated by auxin signaling modules IAA14-ARF7/ARF19-LBD16-CDKA1 and IAA14-ARF7/ARF19-MUS/MUL-XTR6/EXP. Furthermore, as a key regulatory factor, auxin regulates the process of LR initiation and LR primordia (LRP) through different auxin signaling pathway modules.
An Analysis of Hybrid Renewable Energy-Based Hydrogen Production and Power Supply for Off-Grid Systems
Authors: Alharthi Yahya Z.
Published: June 2024

Utilizing renewable energy sources to produce hydrogen is essential for promoting cleaner production and improving power utilization, especially considering the growing use of fossil fuels and their impact on the environment. Selecting the most efficient method for distributing power and capacity is a critical issue when developing hybrid systems from scratch. The main objective of this study is to determine how a backup system affects the performance of a microgrid system. The study focuses on power and hydrogen production using renewable energy resources, particularly solar and wind. Based on photovoltaics (PVs), wind turbines (WTs), and their combinations, including battery storage systems (BSSs) and hydrogen technologies, two renewable energy systems were examined. The proposed location for this study is the northwestern coast of Saudi Arabia (KSA). To simulate the optimal size of system components and determine their cost-effective configuration, the study utilized the Hybrid Optimization Model for Multiple Energy Resources (HOMER) software (Version 3.16.2). The results showed that, when considering the minimum cost of energy (COE), the integration of WTs, PVs, a battery bank, an electrolyzer, and a hydrogen tank brought the cost of energy to almost 0.60 USD/kWh in the system A. However, without a battery bank, the COE increased to 0.72 USD/kWh in the same location because of the capital cost of system components. In addition, the results showed that the operational life of the fuel cell decreased significantly in system B due to the high hours of operation, which will add additional costs. These results imply that long-term energy storage in off-grid energy systems can be economically benefited by using hydrogen with a backup system.
Paul’s Christology in the Corinthian Letters
Authors: Bernard David K.
Published: June 2024

To explore Christian origins, we need to explore Christology, and to study early Christology, Paul’s Corinthian letters are indispensable. In these letters, Paul spoke of Jesus in various ways: fundamentally as a human who died and rose again; sometimes as Yahweh, the one God of Israel; and somehow in distinction from God. While there are various options for understanding Paul’s discussion, the best explanation is that Paul viewed Jesus as the epiphany, manifestation, human personification, or incarnation of the one God. Paul’s language was consistent with Jewish monotheism, used categories of thought available in both Jewish and Hellenistic circles, and did not explicitly delineate two divine persons or two divine centers of consciousness. Instead, he described one transcendent God who became incarnate. In short, for Paul, Jesus is the God of Israel in self-revelation.
Direct Position Determination of Non-Gaussian Sources for Multiple Nested Arrays: Discrete Fourier Transform and Taylor Compensation Algorithm
Authors: Hu Hao , Yang Meng , Yuan Qi , You Mingyi , Shi Xinlei , Sun Yuxin
Published: June 2024

This paper delves into the problem of direct position determination (DPD) for non-Gaussian sources. Existing DPD algorithms are hindered by their high computational complexity from exhaustive grid searches and a disregard for the received signal characteristics by multiple nested arrays (MNAs). To address these issues, the paper proposes a novel DPD algorithm for non-Gaussian sources with MNAs: the Discrete Fourier Transform (DFT) and Taylor compensation algorithm. Initially, the fourth-order cumulant matrix of the received signal is computed, and the vectorizing method is applied. Subsequently, a computationally efficient DPD cost function is proposed by leveraging a normalized DFT matrix to reduce complexity. Finally, first-order Taylor compensation is utilized to enhance the accuracy of the localization results. The superiority of the proposed algorithm is demonstrated through numerical simulation results.
Commuting Stress–Turnover Intention Relationship and the Mediating Role of Life Satisfaction: An Empirical Analysis of Turkish Employees
Authors: Demiral Özge
Published: June 2024

Using hierarchical regression analysis within a mediation model framework, the present study explores the direct and indirect (through life satisfaction) causal impacts of commuting stress on the turnover intention of employees from 29 business organizations in six populous cities in Turkey. A semi-random representative sample of a heterogeneous mix of 214 employees with different demographics was surveyed in both winter and summer in order to capture the seasonal variations in variables. The results support the partially mediating role of life satisfaction in the positive relationship between commuting stress and turnover intention, and infer that commuting stress induces turnover intention both directly and indirectly (by reducing life satisfaction). An analysis of variance reveals that the demographic characteristics of employees such as gender, marital status, age, and family size, along with commuting type and commuting duration, matter for their perceived commuting stress, life satisfaction, and turnover intention levels. Commuting stress perception is relatively higher in the summertime, whereas the other magnitudes are consistently and significantly invariant between the two survey implementations. The study concludes with a call for the consideration of commuting stress and life satisfaction together with environmental and demographic factors when analyzing the antecedents and consequences of employee turnover intentions.
Emociones en diabéticos tipo 2, atendidos en la Unidad Cardiometabólica Dr. Roberto Gutiérrez, Venezuela, febrero-marzo 2018
Authors: Ferrer Villasmil Kenna , Semprún de Villasmil Blanca Irene , Molina Villasmil María José , Ávila Larreal Ayari Guadalupe , Sindas Maribel
Published: June 2024

En la actualidad el estudio de las emociones ha revelado tener una función influyente en la homeostasis del organismo, sin embargo, cuando el equilibrio se interrumpe por emociones negativas se afectan todos los sistemas, propiciando la aparición y/o evolución de enfermedades, entre ellas, diabetes mellitus tipo 2 (DM2). De allí, este estudio propuso como objetivo general analizar las emociones positivas y negativas predominantes en pacientes con DM2 procedentes de la Unidad Cardiometabólica Dr. Roberto Gutiérrez, Maracaibo, Venezuela, bajo el enfoque de la Psiconeuroinmunoendocrinología (PNIE). La investigación fue positivista, descriptiva, transaccional, en 30 pacientes durante el período febrero-marzo 2018, a los cuales se aplicó la escala de emociones de Fredickson. Los datos fueron procesados con el Paquete Estadístico para Ciencias Sociales a través de análisis descriptivos y prueba t de Student. En los resultados predominaron emociones negativas de enojo, seguidas de vergüenza, timidez, culpa, mientras que en las positivas predominaron amor y diversión.
Acceso a la información personal por terceros cuando se demuestra legítimo interés: comparado y florilegio
Authors: Barrigas Cabrera Stalin Vinicio , Macías Alcívar Johana Marisela , Bravo Rodríguez Rocío Elizabeth , Pozo Calderón Edison Manuel , Solórzano Vélez Shirley Vicenta
Published: June 2024

En la era digital, la información personal ha adquirido un valor inimaginable, convirtiéndose en un activo de gran importancia tanto para las empresas como para el Estado. El objetivo del estudio es comprender el acceso a la información personal por terceros cuando se demuestra legítimo interés comparado y florilegio. El enfoque es cualitativo, la metodología es tipo jurídica documental, interpretativa y hermenéutica. La técnica fue revisión bibliográfica. Los resultados apuntan que los países sudamericanos han avanzado en la protección de datos personales, pero se deben fortalecer los marcos legales y garantizar la protección de la información personal. En cuanto a la Legislación Europea La protección de datos personales ha cobrado importancia en la era digital. Se concluye que, tanto a nivel latinoamericano como europeo, se establece el principio de reserva de información personal, garantizando que la información personal solo puede ser revelada a terceros en circunstancias excepcionales y siempre bajo el amparo de la ley.
The The Impact of Overt Strategy Instruction in EFL Classrooms on Reading and Listening Achievement
Authors: Kahveci Pınar , Tavil Zekiye Müge
Published: June 2024

Language learning strategies may have a key role in foreign language learning because they may foster learner autonomy and motivation. Keeping the learner-centred nature of language learning strategies in mind, this study set out to understand the impact of overt listening and reading strategy instruction on learners’ listening and reading achievement. The study employed an explanatory mixed-method research design. Research instruments were reading and listening achievement tests and semi-structured interviews. The treatment involved overt listening and reading strategy instruction that lasted for four weeks. The findings revealed that overt listening and reading strategy instruction fostered learners’ reading and listening achievement. Similarly, semi-structured interviews revealed that learners were willing to transfer the strategies they learned to new learning situations and keep using these strategies in future learning situations.
Impact of Language Processing on the Growth of Cognitive Abilities
Authors: Vidya Krishnan R , Vinodhini S
Published: June 2024

Language is a key factor in influencing cognitive development, and there is a complicated and entwined relationship between language and cognitive science. The relationship between language and cognitive science is further explored through the study of brain functions and mind, leading to the emergence of disciplines like cognitive neuroscience and neurolinguistics. Cognitive development is greatly impacted by language processing in a number of ways. First, memory development is influenced by language processing. Secondly, domain-general cognitive functions including representational ability, processing speed, and attention are necessary for language processing. Thirdly, there is a connection between language processing and cognitive growth; language processing promotes learning, reasoning, memory, and attention.
Kazuo Ishiguro’s Klara and the Sun: A Posthumanist Anatomization
Authors: Catherine Benita P
Published: June 2024

Kazuo Ishiguro’s eighth novel Klara and the Sun is a quintessence to manifest Ishiguro’s power when he tactfully explored the new arena of technology that encompasses Artificial Intelligence and Gene Editing. The novel stands as a test of time to prove Ishiguro’s humanitarianism in the post era of pandemic. While transhumanism is on the rise, the society is in a great flux across the globe with speedy technology that marches to post humanist epoch. It is a watershed moment to wake up to the fact that breakthrough in technology has mixed blessings and albeit the high fidelity world provides sophisticated artificial intelligence to aid human existence, still there are certain things a machine has less competence doing. The article aims to give a panoramic view of how the novel foreshadows post anthropocentric world where it questions the identity of human dignity and how with the leading edge of technology viz. gene editing to push the frontier of the human excellence for the maximum reap will come home to roost.
Discerning Pervasive Figures of Speech in English Poetic Constructions
Authors: Sharma Lok Raj
Published: June 2024

A figure of speech serves as a literary device, strategically employing words or phrases in a manner that transcends their literal meanings, and creates a distinct effect. This article aims to discern pervasive figures of speech in English poetic constructions crafted by various poets. Employing a qualitative stylistic approach, the article involves examples as the demonstrations,boldface words as discernment and explication of discerned figures of speech as clarification. It reveals the findings that figures of speech in poetic construction suggest rich layers of meaning, evoke vivid imagery and emotions, convey symbolic significance, enhance the musicality of the text, and invite readers to engage in interpretation and exploration. They are essential tools for poets to express complex ideas and evoke profound emotional responses from their readers. It is expected to prove beneficial to college students pursuing poetry as a major subject, as well as teachers keen on instructing figures of speech in English poetry. It is significant as it indicates that enhanced capacity for memorization and comprehension of figures of speech augments the overall grasp of poetic constructions thereby fostering a more profound understanding of entire poems among both students and teachers.
The Confrustion Constellation: A New Way of Looking at Confusion and Frustration
Authors: Baker Ryan Shaun , Cloude Elizabeth , Andres Juliana , Wei Zhanlan
Published: June 2024

There has been considerable research on confusion and frustration that has treated them as two unitary constructs, distinct from each other. In this article, we argue that there is instead a constellation of different types of confusion and frustration, with different antecedents, manifestations, and impacts, and that the commonalities between many types of confusion and frustration justify thinking of them as part of the same constellation of affect, distinct from other prominent affective categories. We discuss how these types of affect have been considered historically and in key models. We then discuss unusual manifestations of each form of affect that have been documented in the literature, and what light they shed on the broader constructs. We conclude with a discussion of a new theoretical framing that treats confusion and frustration as a confrustion constellation, and the opportunities and open questions that this perspective presents.
الأثر الفوري للحجامة الانزلاقية على المصابين بآلام أسفل الظهر عضلية المنشأ لدى العاملين في جامعة مؤتة
Authors: القضاة محمد
Published: June 2024

هدفت هذه الدراسة التعرف إلى الأثر الفوري للحجامة الانزلاقية كاستجابة فورية على المصابين بآلام أسفل الظهر عضلية المنشأ، وذلك وفقاً للمتغيرات الآتية (درجة حرارة الجزء الأيمن في أسفل الظهر، درجة حرارة الجزء الأيسر في أسفل الظهر، المدى الحركي للجذع إلى الأمام، المدى الحركي للجذع إلى الخلف)، وقد تم استخدام المنهج التجريبي لملائمته لطبيعة وأهداف الدراسة، وذلك على عينة تكونت من (13) من المصابين بآلام في منطقة أسفل الظهر من الدرجة الخفيفة من العاملين في جامعة مؤتة والذين يراجعون المركز الصحي، حيث تم اختيارهم بالطريقة العمدية وإخضاعهم لجلسة واحدة من الحجامة الانزلاقية ولمدة دقيقة واحدة فقط، واستخدم الباحث الاختبارات كأداة لجمع البيانات، واستخدم برنامج الرزم الإحصائي (SPSS) لتحليل النتائج وتحليل ويلكوكسون للمقارنة بين القياسات القبلية والبعدية. وأظهرت النتائج وجود فروق ذات دلالة إحصائية بين القياسين القبلي والبعدي لصالح القياس البعدي على مستوى درجة حرارة الجزء الأيمن في أسفل الظهر، درجة حرارة الجزء الأيسر في أسفل الظهر، المدى الحركي للجذع  إلى الأمام، المدى الحركي للجذع إلى الخلف. وقد استنتج الباحث بأن لاستخدام الحجامة الانزلاقية لمدة دقيقة واحدة فقط أثر إيجابي فوري كاستجابة فورية على المرضى المصابين بآلام أسفل الظهر عضلي المنشأ من الدرجة البسيطة. وأوصى الباحث بإجراء المزيد من الدراسات المشابهة على عينات أكبر وبالطريقة التتبعية من أجل تحديد مدى استمرارية ذلك الأثر الفوري، كذلك وإجراؤها على حالات آلام أسفل الظهر من درجات الألم المتوسطة والحادة، كذلك وعلى آلام أسفل الظهر غير النوعي غير عضلية المنشأ.
قَصْدِيَّةُ الخِطَابِ القُرآنيّ والاحْتِمَالاتِ التَأْوِيْلِيّة - ذُرّيّةُ نُوْحٍ والطُّوْفَانِ أُنْمُوذَجًا
Authors: البديرات باسم , الذنيبات فايز
Published: June 2024

تسعى هذِهِ المُقاربةُ التَّأْويْليَّةُ إلى إِظْهارِ مَكْنُونَاتِ الخِطاْبِ القُرْآنِيِّ الخاْصِّ بِذُريَّةِ نُوْحٍ -عَلَيْهِ السَّلامُ- وَالطُّوْفَانِ؛ لأَنَّ هَذَيْنِ المَوْضُوْعَيْنِ حَظِيا بِترْكِيْزٍ وَاْفِرٍ فِي السّياقَاْتِ القُرْآنِيَّةِ، غَيْرَ أَنَّ مُعْظَمَ التَّأْوِيْلاتُ المُتعَلِقَةُ بِهِمَا جَاْءَتْ مُتَأثِّرةٌ بِأَدَبِيّاتِ أَهْلِ الكِتَابِ إِلى حَدٍّ كَبِيِرٍ؛ نَظَرَاً لِوُجُوْدِ قِصَّةِ نُوْحٍ عندهم، وَمِنْ هُنَاْ نَجِدُ بَوْنَاً وَاْضِحَاً بَيْنَ الدِّلالَةِ القَصْدِيَّةِ لِلْخِطَابِ القُرْآنِيّ وَبَيْنَ المَأْثُوْرِ المُتدَاوَلِ حَوْلَ أَحْدَاْثِهِمَا. وَهَذَا الأَمْرُ كَاْن مُحَفِّزَاً كَبِيْرَاً لِاجْتهادٍ فِي إِيْجَاْدِ تَأْوِيْلٍ يَتَوَاءَمُ مَع السِّيَاْقَاْتِ القُرْآنِيَّةِ كُلِّها وَلَا يَتَغَاْضَى عَنْ أَيِّ دَلِيْلٍ مٍنْهَا.
Sintesis Nanokomposit Nata de Coco/Grafena Oksida Sebagai Adsorben Ion Logam Timbal
Authors: Lantu Gideon , Kamu Vanda Selvana , Aritonang Henry F.
Published: June 2024

ABSTRACT
In this study, bacterial cellulose was synthesized using waste coconut water from Tetey, North Region, North Sulawesi and was inserted with graphene oxide using in-situ method. Mass variations of graphene oxide were inserted into bacterial cellulose with variations of 0.1 g, 0.2 g, and 0.3 g. The bacterial cellulose/graphene oxide nanocomposite was then used as an adsorbent for lead metal (Pb). The resulting nanocomposite was characterized using Fourier-Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX), and X-Ray Diffraction (XRD). The results of these characterizations proved that bacterial cellulose/graphene oxide was formed. Adsorption test showed that nanocomposite of bacterial cellulose/graphene oxide could act as adsorbent. The results of the analysis showed that the the greater the mass of GO inserted inti bacterial cellulose, the higher the Pb adsorption percentage.
Keywords: bacterial cellulose/graphene oxide, adsorption, lead metal (Pb).
 
ABSTRAK
Dalam penelitian ini telah dilakukan sintesis nanokomposit nata de coco dari air kelapa yang diambil dari Tetey, Minahasa Utara, Sulawesi Utara dan diinsersi dengan grafena oksida menggunakan metode in-situ. Variasi massa grafena oksida yang diinsersi ke dalam nata de coco dengan variasi 0,1 g, 0,2 g, dan 0,3 g. Nanokomposit nata de coco/GO digunakan sebagai adsorben logam timbal (Pb). Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX), X-Ray Diffraction (XRD), dan Fourier-Transform Infrared Spectroscopy (FT-IR) digunakan sebagi instrumen karakterisasi nanokomposit. Hasil karakterisasi tersebut membuktikan bahwa nanokomposit nata de coco/grafena oksida telah terbentuk. Berdasarkan hasil analisis menggunakan Atomic Adsorption Spectroscopy (AAS) menunjukkan bahwa nanokomposit nata de coco/GO mampu bertindak sebagai adsorben. Hasil analisis menunjukkan bahwa nilai persentase adsorpsi semakin besar dengan bertambahnya massa GO yang diinsersi ke dalam nata de coco..
Kata kunci: nata de coco/grafena oksida, adsorpsi, logam timbal (Pb).
PENGELOLAN AIR LIMBAH DOMESTIK DKI JAKARTA DI TINJAU DARI PENGELOLAAN AIR LIMBAH DOMESTIK DI SINGAPURA
Authors: Soefianto Soetono
Published: June 2024

This study aims to identify the problems of managing waste water into clean water in the Special Capital Region of Jakarta from the perspective of Water Resources Law. Using a normative juridical approach, namely a legal research method carried out by examining library materials or secondary data. The results of the research show that waste water management in the State of Singapore can be said to be quite successful and can be an example to be adopted and implemented in DKI Jakarta as part of the form of handling in order to realize the mandate of Article 33 Paragraph (3) of the 1945 Constitution, namely distributed social justice in responding to legal reality regarding the purpose of water as a social asset and capital asset so as to close the gap in privatization of water by the private sector.
STRATEGI KEBIJAKAN PERTUMBUHAN HIJAU (GREEN GROWTH) INDONESIA: DALAM ADAPTASI PERUBAHAN IKLIM
Authors: Dewi Ayu Marchela Putri  , Langgeng Rachmatullah Putra
Published: June 2024

The purpose of this research is to understand and discuss Indonesia's green growth strategies in facing global challenges related to climate change The main focus of this study lies in policy adaptation and practices that support climate change mitigation and adaptation, taking into account both local and global contexts. Through secondary data analysis, this article identifies the main challenges faced by Indonesia, such as increasing greenhouse gas emissions and deforestation Additionally, the article evaluates government and private sector initiatives in promoting renewable energy, natural resource conservation, and enhancing community adaptation capacity. Research findings indicate that the success of Indonesia's green growth strategy heavily relies on multisectoral collaboration, increased public awareness, and strong political commitment The conclusion of this article emphasizes the need for a holistic and inclusive approach in designing policies and implementing them to achieve sustainable economic growth and climate resilience.
Numerical Evaluation and High Precision Approximation Formula for Landau Distribution
Authors: Yoshimura Takuma
Published: June 2024

The Landau distribution is an important distribution in physical sciences that describes the statistical property of the energy loss by charged particles as they traversing a thin layer of matter. However, this distribution is difficult to treat analytically and requires integration for numerical evaluation. The CERNLIB-G110 approximation, which is currently widely used, is accurate to within 8-9 digits of the relative error. In this paper, an approximate formula with 16-digit relative error, which is accurate enough for double type of IEEE754, and an approximate formula with 34-digit relative error for float128 are obtained. In addition to the approximation, numerical evaluation of Landau distribution and random number generation method are also presented.
Detecting LLM Hallucinations Using Monte Carlo Simulations on Token Probabilities
Authors: Ledger Grant , Mancinni Rafael
Published: June 2024

Hallucinations in AI-generated content pose a significant challenge to the reliability and trustworthiness of advanced language models, particularly as they become increasingly integrated into decision-making processes across various domains. The novel concept of employing Monte Carlo simulations on token probabilities offers a robust framework for detecting hallucinations, enhancing the accuracy and reliability of AIgenerated content. The methodology involved generating multiple outputs for diverse prompts, calculating token probabilities, and performing Monte Carlo simulations to identify low-probability tokens indicative of hallucinations. Experimental results revealed varying frequencies of hallucinations across different domains, with everyday scenarios presenting the highest challenge. The probabilistic framework enabled a detailed analysis of the LLM’s outputs, providing insights into its decision-making process and highlighting the efficacy of the Monte Carlo approach. The study’s findings underscore the importance of refining LLMs to improve their performance and reliability in real-world applications, contributing to the ongoing efforts to mitigate hallucinations in AI-generated content.
Hybrid Model using LOF and iForest Algorithms for Detection of Insider Threats
Authors: Mahajan Anvita
Published: June 2024

Insider threats, is one of the most challenging threats in cyberspace,
usually responsible for causing significant loss to organizations. The
topic of insider threats has long been studied and many detection
techniques were proposed to deal with insider threats. This paper
focuses on using different anomaly detection algorithms- Locality
Outlier Factor Algorithm and Isolation forest Algorithm and does a
comparative analysis between their performance. A hybrid model
incorporating advantages of both LOF Algorithm and IF Algorithm is
proposed in this paper which gives better performance than the
individual models for detecting insider threats. The hybrid model was
able to achieve whooping 99.99\% accuracy while
detecting insider threats.
A ciascuna disciplina il suo risultato. Classi digitali vs. classi a didattica tradizionale: un confronto negli esiti degli apprendimenti
Authors: Fiore Brunella
Published: June 2024

In recent years, Italy has embarked on a transformative journey to embrace technology in education. This article focuses on the adoption of digital technologies, with particular attention to the digital classroom initiative. The digital classroom experience aims to utilize digital tools and resources to facilitate an engaging and innovative mode of learning for students. This contribution examines the effects of student participation in digital classrooms on learning outcomes, comparing them with traditional classrooms within the three-year curriculum of a lower secondary school. Through an evaluative approach based on representative data from a sample of over 200 students, we analyze the impact of digital classrooms on INVALSI test results. The analyses encompass descriptive models and linear regression models applied to the results of tests in Italian, Mathematics, English Reading, and English Listening. The models introduce control variables related to the socio-economic and cultural status of the students’ families of origin, as well as their prior performance in INVALSI tests (grades II and V), for students continuing in the same institution through the primary cycle. The results indicate the need for distinct considerations depending on the discipline under analysis: for Mathematics, belonging to a traditionally taught class seems to yield better results. In the case of Italian, English Reading, and English Listening, the effect is neutral. Socio-economic and cultural status appears to have less influence on English-related disciplines, and the trend, though not statistically significant, demonstrates partially positive effects in digital classroom participation, particularly for students with cognitive vulnerabilities. The outcomes underscore the necessity of discipline-specific differentiation and further assessment of outputs to delve into the specifics of innovative didactics implemented in digital classrooms.
Renal AA Amyloidosis in Ankylosing Spondylitis: A Case Report
Authors: Ahmed A H Hamid , Ahmed Shamim , Arnob Ahmed Showki , Hossain SK Afsana , Nawal Noshin , Rahman A.K.M Shahidur
Published: June 2024

Ankylosing spondylitis (AS) is a chronic inflammatory joint disease of seronegative spondyloarthropathies (SpA). Secondary amyloid A amyloidosis (Amyloidosis AA) is an uncommon complication of ankylosing spondylitis (AS). Amyloidosis AA is a systemic disease characterized by amyloid deposition in many organs including kidneys. An amyloid fibril formation starts with inappropriate folding of amyloidogenic precursor proteins. The amyloid fibrils have a typical appearance on light microscope that could be easily identified. The classification of secondary amyloidosis is based on the precursor proteins that form amyloid fibrils along with systemic and local distribution of amyloid deposition. Renal involvement is most frequent in systemic amyloidosis. The clinical manifestation of renal amyloidosis differs depending on the type of amyloid protein with the location and amount of amyloid deposition. The treatment of amyloidosis should be focused on managing symptoms and stabilizing amyloid protein.
A Case of Gougerot Sjögren Syndrome (SGS) Discovered by Chronic Pulmonary Impairment at the Nianankoro Fomba Hospital in Segou
Authors: D Camara, B. , M Dramé Boubacar, , O Coulibaly, , K Dao, , A Coulibaly, , Mala Sylla , Kaly Keïta , Djibril Sy , Koné A. , A Drago, A. , I Dollo, , O Kamissoko, C. , A Maiga, , M Diakité, , H Guindo, , Sow D. S.
Published: June 2024

Introduction: Sjögren's syndrome (SS) is a systemic autoimmune disease whose target is the epithelium of the exocrine glands and in particular the salivary glands. SS affects women more often with a sex ratio of 9 women to 1 man and the peak frequency is around age 50. It is mainly described in Western literature where it seems to come second after RA. In Africa, it is mainly reported in the Maghreb. We report a case, revealed by pulmonary damage at the Nianankoro Fomba hospital in Ségou. Observation: This was a patient, aged 50, without any particular ATCD, who had consulted for chronic cough with mucco-purulent sputum and dyspnea, which had been present for more than four (4) months. Faced with the failure of a trial anti-tuberculosis treatment despite the negativity of the sputum testing for BARR in the Pneumophthisiology department, she decided to consult internal medicine. Clinical examination revealed NYHA stage III dyspnea. A chest CT concluded with bilateral pulmonary parenchymal interstitial syndrome associated with inflammatory bronchopathy with bronchiectasis. The immunological assessment revealed positive anti–SSA and anti–SSB Abs. Clinical improvement was obtained after initiation of corticosteroids and immunosuppressants. Conclusion: This observation illustrates the interest of looking for latent SS in the etiological assessment of a persistent cough.
Infant Feeding Pattern during the First Six Months of Age among Primipara Mothers
Authors: Alsalamah Afnan Abdullah , D’Sa Juliana Linnette
Published: June 2024

The exclusive breastfeeding (EBF) rates are low globally and in Saudi Arabia. This study aimed to identify the type of infant feeding practiced during the first six months of age and determine if there is an association between demographic characteristics and the type of breastfeeding. A descriptive cross-sectional survey was conducted on 401 primipara mothers who attended 15 primary health care centers (PHCCs)by using a self-administered questionnaire. Only 17.2% of infants were exclusively breastfed, and 65.8% were given mixed feeding in the first six months of life. The breastfeeding rate declined from 99.8% in the first month to 76.3% by six months, with a corresponding increase in the use of formula milk, plain water and dates from 31.7%, 24.9%, and 24.7% in the first month to 53.1%. 49.1%, and 32.7% in the six months, respectively. Mothers also used herbs, lump sugar, glucose water and honey every month. A chi-square test reveals no association between the demographic characteristics and type of breastfeeding (EBF, predominant breastfeeding and mixed feeding). The primipara mothers had low EBF rates indicating the need to provide culture-specific education, support and counselling.
It Takes a Thief…. and a Bank: Protecting Consumers from Fraud and Scams on P2P Payment Platforms
Authors: Lesser Mansfield Cathy
Published: June 2024

This Article proposes statutory and regulatory changes to the Electronic Fund Transfer Act; Regulation E; and the Bank Secrecy Act/Anti-Money Laundering regulations to protect consumers who use instant payment platforms in the United States (such as Zelle and Venmo) from scam artists and fraudsters. After discussing current fraud scams on these payment platforms, the Article discusses the history and context of the 1978 Electronic Fund Transfer Act and Regulation E, and the definition of unauthorized payments and payments made in error therein. The second part of this Article explores changes to the Bank Secrecy Act/Anti-Money Laundering regulations that might make it hard for fraudsters to use the financial system to commit fraud, and might make it easier for financial institutions to identify fraudsters seeking to do so. Finally, this Article provides an update on regulatory, legislative, and judicial activity that took place while this Article was in the process of being published.
THE RISE AND FALL OF WORKING STUDENTS AMIDST COVID-19 PANDEMIC
Authors: Jestoni P. Trozo
Published: June 2024

The researchers aim to identify the different underlying struggles to the working students when the covid-19 became a pandemic that resulted into lockdowns and shutdown of different educational institution. Qualitative approach is being used in this research in which involves collecting and analyzing non-numerical data (e.g., text, video, or audio) to understand concepts, opinions, or experiences. It is applicable to gather in-depth insights into a problem or generate new ideas for research. We have ten (10) participants which are all qualified to be one. We the researchers formulated an virtual interview anchored on the research questions. We gathered themes, and sub-themes through Thematic Content Analysis which assist the descriptive qualitative data presentation. The two major themes are the struggles of the working students and coping mechanisms. The sub-themes are financial struggle, time management, resilient working student, personal strength, and family as a support network. Majority of the respondents had experienced financial and time management struggle during the covid-19 pandemic. The majority of them also reiterated that their source of motivation is their family. With all the challenges they have encountered, they remained motivated through the help of their different support system like their family. Hence, the study demonstrates the struggles as part of the process of a working student.
KEYWORDS: the rise and fal, working students, amidst covid-19 pandemic
Pengaruh Sistem Akuntansi Manajemen, Kualitas Informasi, dan Ketidakpastian Lingkungan Terhadap Kinerja Manajerial
Authors: Sanputra Adrian Hartanto Darma
Published: June 2024

This research aims to examine the influence of management accounting systems, information quality, and business environmental uncertainty on organizational performance at APERSI Association. The research hypotheses posit that management accounting systems, information quality, and business environmental uncertainty significantly affect organizational performance at APERSI Association. The study utilizes primary data in the form of respondent assessments regarding management accounting systems, information quality, business environmental uncertainty, and organizational performance. Data collection methods include questionnaires and literature reviews. The analysis using SMART PLS 4.0. The findings of the research are as follows: (1) management accounting systems have a positive and significant impact on organizational performance; (2) information quality has a positive and significant impact on organizational performance; (3) business environmental uncertainty has a positive and significant impact on organizational performance
Determinan Persepsi Mahasiswa Mengenai Penggelapan Pajak dengan Penerapan Teknologi Informasi sebagai Variabel Moderasi
Authors: Latifah Jihan , Yeni Fitri , Permata Sari Putri Intan
Published: June 2024

The aim of this research is to determine the factors that have an impact on students' views regarding tax evasion with the application of information technology as a moderating variable. The sample in this research is accounting students class of 2020 concentrating on taxation at Putra Indonesia University "YPTK" Padang. The selection of students as samples was based on the reason that they represent the future generation of taxpayers. The aim is to contribute to reducing tax evasion behavior, overcoming various practices that deviate from tax obligations. The sampling technique for this research used convenience sampling. Respondents in this study totaled 128 respondents. Data analysis using multiple linear regression with SPSS 26 tools. Based on the findings, it was found that tax justice and tax discrimination had a positive and significant impact on students' perceptions or views regarding tax evasion, but not the tax system. IT as a moderating variable has a partial moderating influence on the relationship between tax justice and students' perceptions or views regarding tax evasion. However, it cannot moderate the influence of the tax system and tax discrimination on student perceptions or views regarding tax evasion among accounting students with a tax concentration class of 2020 at UPI "YPTK" Padang.
Establishment of a myostatin gene-knockout C2C12 cell line and evaluation of related microRNA expression
Authors: Weng Shaoting , Lian Kaiqi , Zhang Kunpeng , Ma Shengming , Zhang Wenhui , Luo Zhongyi , Chen Ruifeng , Wang Liqiang , Lin Sen , Ji Xinying , Wang Yao
Published: June 2024

The strategy of blocking myostatin (MSTN) signal transduction has long been regarded as a promising approach in the treatment of patients with muscle loss. However, individuals taking blocking agents often encounter issues such as lack of strength, fatigue, and poor muscle proliferation due to muscle hypertrophy and the involvement of multiple receptors. To address these challenges, a series of experiments were conducted on a C2C12 cell line in this study. First, the pX601-SaCas9-sgRNA/puro vector carrying a Cas9-encoded gene was constructed and subsequently used to produce Mstn-knockout (Mstn-KO) C2C12 cell lines. The expression level of the MSTN protein and the growth characteristics of the cell lines were verified. Moreover, the expression of muscle growth-related microRNAs in the cell lines was analyzed through real-time polymerase chain reaction (PCR). The results indicate that we have successfully established a method for constructing Mstn-KO cell lines with stable passage. No expression of the MSTN protein and strong cell proliferation were observed in the cell lines. Moreover, real-time PCR experiments showed that the expression levels of miR-1, miR-431, miR-206, and miR-133a were significantly increased (P < 0.01), the expression level of miR-23a was significantly increased (P < 0.05), and the expression level of miR-486 was significantly decreased (P < 0.05). These findings indicate that multiple miRNAs are closely associated with MSTN regulation. This study lays the foundation for further investigation into the effects of the Mstn gene on the physiological function of myoblasts and the development of drugs that block the MSTN signaling pathway.
TOPK: A noteworthy target for lung cancer treatment
Authors: Liu Wenbo , Zhu Feng , Duan Qiuhong , Li Yafang , Zhao Shuang , Xiao Juanjuan , Zhang Yijie
Published: June 2024

T-LAK cell-originated protein kinase (TOPK) is a serine/threonine protein kinase that is specifically expressed in actively proliferating cells, such as normal testicular germ cells, lymphocytes, and various tumor cells. It plays a key role in multiple biological processes, such as cell growth, metastasis, drug resistance, angiogenesis, and inflammation, and is a promising therapeutic target for tumors. Aberrant TOPK overexpression or activation has been observed in lung cancer and is related to lung cancer occurrence and development, clinical outcome, and poor prognosis. The inhibition of TOPK has demonstrated significant therapeutic potential for reducing tumor growth and can even be used in combination with chemotherapy or radiotherapy. Thus, targeting TOPK provides a promising avenue for the prevention and treatment of lung cancer. This article reviews the role of TOPK in the occurrence, development, and drug resistance of lung cancer; summarizes the main signaling pathways affected by TOPK in lung cancer; and analyzes its therapeutic value. The role and potential of TOPK in targeted therapy, chemotherapy, radiotherapy, and immunotherapy for lung cancer are also discussed. In addition, the latest progress in the use of TOPK inhibitors for lung cancer treatment is summarized, and their future clinical application is discussed. Overall, TOPK is a valuable target for the treatment of lung cancer, and further development of specific TOPK inhibitors is indispensable for the comprehensive treatment of lung cancer.