bluuebunny/crossref_metadata_2025 huggingface dataset:
A Collector Deceives—About the Ways of Deceiving Women by Men and Men by Women as far as Spending Money on Collecting Items Is Concerned
Authors: Wirga Tomasz , Kopczak-Wirga Anna
Published: December 2022

The presented research shows that neither women nor men are honest with their partners when informing them about the amount of money spent on collecting items. Their behaviour may show signs of addiction to collecting. Men in comparison to women spend more and are less likely to lower the amounts of money spent on collected items. Those who earn more spend more on their collections. Women and men also use different techniques of hiding their expenses. Women do not inform about their expenses using denying techniques (such as saying that it was bought/borrowed a long time ago, etc.), whereas men inform about expenses but use preventive techniques (such as exchange). What is more, men tend to use a technique of lowering real costs “by a given amount”, whilst women use a technique “up to a given amount”; that is, they inform that they did not spend more than a given amount. In addition, the partners of collectors are aware that they are being cheated. On the other hand, collectors see the motivation for their lies in the misunderstanding of the hobby by their partners.
Adolescent Development and the Parent–Adolescent Relationship in Diverse Family Forms Created by Assisted Reproduction
Authors: Quintigliano Maria , Carone Nicola , Speranza Anna Maria , Tanzilli Annalisa , Baiocco Roberto , Barone Lavinia , Pastorelli Concetta , Lingiardi Vittorio
Published: December 2022

Assisted reproduction techniques (ARTs) are employed by single individuals and couples who are not otherwise able to conceive spontaneously. While the use of ARTs is increasing, research is lacking on the attempts made by adolescent offspring conceived via ARTs to integrate their ART conception into their identity and negotiate a connection with, and autonomy from, their parents. The present article reviews studies investigating adolescent development and the parent–adolescent relationship in diverse family forms created by ARTs (mainly heterosexual and lesbian parent families), and discusses the results in light of attachment, identity development, and emotional distance regulation theories. Overall, the results indicate that the psychological adjustment of adolescents conceived via ARTs is not undermined by the manner of their conception, and that they enjoy positive relationships with their parents with no difference from those enjoyed by spontaneously conceived adolescents. However, it remains unknown whether the development of a reproductive identity in adolescence is likely to influence adolescents’ interest in searching for or contacting their donors, surrogates, and/or donor siblings. The results suggest the relevance of considering the parent–adolescent relationship, disclosure, and identity formation issues when planning psychological counseling and support interventions with ART parents and their adolescent offspring, and emphasize the need to further investigate these aspects in diverse ART families, including single-, gay-, bisexual-, and trans*-parent families.
Social Determinants of Mental, Physical, and Oral Health of Middle-Aged and Older African Americans in South Los Angeles
Authors: Adinkrah Edward , Najand Babak , Rahmani Arash , Maharlouei Najmeh , Ekwegh Tavonia , Cobb Sharon , Zare Hossein
Published: December 2022

Background. A growing body of research suggests that financial difficulties could weaken the protective effects of socioeconomic status (SES) indicators, including education and income, on the health status of marginalized communities, such as African Americans. Aim. We investigated the separate and joint effects of education, income, and financial difficulties on mental, physical, and oral self-rated health (SRH) outcomes in African American middle-aged and older adults. Methods. This cross-sectional study enrolled 150 middle-aged and older African Americans residing in South Los Angeles. Data on demographic factors (age and gender), socioeconomic characteristics (education, income, and financial difficulties), and self-rated health (mental, physical, and oral health) were collected. Three linear regression models were used to analyze the data. Results. Higher education and income were associated with a lower level of financial strain in a bivariate analysis. However, according to multivariable models, only financial difficulties were associated with poor mental, physical, and oral health. As similar patterns emerged for all three health outcomes, the risk associated with financial difficulties seems robust. Conclusions. According to our multivariable models, financial strain is a more salient social determinant of health within African American communities than education and income in economically constrained urban environments such as South Los Angeles. While education and income lose some protective effects, financial strain continues to deteriorate the health of African American communities across domains.
Benefits of Cycling Wheelchair Training for Elderly with Physical Disability: A Prospective Cohort Study
Authors: Fu Jimmy Chun-Ming , Fu Pin-Kuei , Cheng Yuan-Yang
Published: December 2022

Aim: In order to investigate the effect of cycling wheelchair training as an exercise for aged 65+ disabled patients on cognitive function, quality of life, aerobic capacity and physiological parameters. Methods: Participants in nursing home performed cycling wheelchair training for 30 min a day, 5 days a week, for a total of 4 weeks. The main outcome measure was the short form 12 survey (SF-12). Other outcome measures included the Mini-Mental State Examination (MMSE), aero bike work rate test, resting blood pressure, and heart rate. Results: In this study, 41 volunteers were recruited and no participants dropped out of the study voluntarily during training, and no serious adverse effect was identified. Physical and mental component summary total scores of SF-12 were significantly higher after training with statistical significance (p = 0.001). 8 subscales also showed significant improvements after training (p = 0.025 ~ <0.001). Total MMSE score has no difference before and after training. Attention/calculation (p = 0.018), short term memory (p = 0.041), and aerobic capacity (p < 0.001) as measured by subscales of MMSE and aero bike test showed marked improvements, while resting systolic blood pressure (p = 0.931) and heart rate (p = 0.793) did not change. Conclusions: Cycling wheelchair is practical for the disabled elderly to exercise, and a 4-week exercise program enhanced their quality of life and aerobic capacity.
Carbonyl Profiles of Electronic Nicotine Delivery System (ENDS) Aerosols Reflect Both the Chemical Composition and the Numbers of E-Liquid Ingredients–Focus on the In Vitro Toxicity of Strawberry and Vanilla Flavors
Authors: Noël Alexandra , Ghosh Arpita
Published: December 2022

Propylene glycol (PG) and glycerin (G) are the most widely used humectants in electronic nicotine delivery system (ENDS) devices. Carbonyls are present in aerosols produced when ENDS devices heat PG and G. Whether aerosolized PG and G are innocuous to the lungs has not been established. Here, we determined the chemical profiles of ENDS aerosols containing three humectant ratios (30/70, 50/50 and 70/30, PG/VG), for three flavors (strawberry, vanilla and Catalan cream) containing either 12 or 18 mg/mL of nicotine. Additionally, we examined the in vitro toxicity of the strawberry- and vanilla-flavored ENDS aerosol in human lung epithelial cells (BEAS-2B) exposed at the air-liquid interface for 1 h. For strawberry- and vanilla-flavored aerosols produced by a 3rd-generation ENDS device with the same PG/G ratio, the e-liquid nicotine content of 12 and 18 mg/mL did not transfer to the aerosol with substantial differences in concentrations. Our data also indicate the presence of carbonyls in all three flavored e-cig aerosols analyzed, with levels exceeding 1 µg/puff for acetone, butyraldehyde, and acetaldehyde, in strawberry-, vanilla, and Catalan cream-flavored e-cig aerosols, respectively. Furthermore, closed-system ENDS of the fourth generation emitted trace levels of carbonyls in the aerosols (<0.3 µg/puff), while open-system tank-style ENDS of the third generation produced elevated levels of harmful chemicals, including acrolein (>1 µg/puff), formaldehyde (>5 µg/puff), and m- & p-tolualdehyde (>4 µg/puff). Moreover, under non-cytotoxic conditions, BEAS-2B cells exposed to strawberry-flavored aerosols exhibited significantly increased reactive oxygen and nitric oxide species (ROS/NOS) levels in cell media compared to air controls, while vanilla-flavored ENDS aerosols up-regulated the expression of pro-inflammatory and oxidative stress markers. Our data suggest (a) that ENDS aerosol chemical composition will vary based upon the presence and concentration of the initial e-liquid ingredients, with a pronounced impact of the flavoring components; and (b) short-term exposures to flavored ENDS aerosols may impair lung cells’ redox signaling in a flavor-specific manner.
Transformation of Children’s Paintings into Public Art to Improve Public Spaces and Enhance People’s Happiness
Authors: Luo Na , Ibrahim Rahinah , Abidin Sazrinee Zainal
Published: December 2022

Characteristics of children’s paintings have been suggested considered for application in public art since they are known to positively evoke a sense of well-being when people see them. This study aims to understand the impact of artistic features from children’s drawings on people’s well-being; then analyzing the adaptive design principles of 3D public art featuring children’s paintings on people’s happiness; and finally, exploring the influence of 3D public art featuring children’s paintings on improving public spaces and enhancing people’s well-being. The results lead to proposing a conceptual framework for public artworks in public spaces for improving people’s happiness. The proposed conceptual framework recommends that, by applying the visual and thinking features of children’s paintings to public art, artists can design high-quality artworks suitable for a city, which could improve people’s happiness in public spaces. This study recommends further research into how public art can promote public spaces and shape the urban culture. It contributes to enhancing the quality of public art and public spaces, and inspiring a sense of well-being among citizens through the use of appropriate public art. The results are significant because they will help artists to create more high-quality public artworks for urban public spaces in order to evoke people’s happiness.
Teaching of the Black Population’s Health: Anti-Racist Lenses for a Paradigm Shift to Address Racial Inequities
Authors: Carrijo Ana Paula Borges , de Moura Anna Luísa Dias Bastos , Oliveira Augusto Cézar Polveiro e , Rodrigues Lígia Villela , de Oliveira Janaina , de Castro Thiago Figueiredo , Torres Odete Messa , Poças Katia Crestine , Deusdará Rodolfo
Published: December 2022

Health (and its dialectical pair—illness) is determined by multiple factors: social class, educational background, income, occupation, and race/skin color. Racism can directly impact physical and psychological illnesses, with an effect on social conditions of health. This paper discusses: (1) racism as a root cause of health inequities in Brazil and elsewhere, and (2) how students at the University of Brasilia School of Medicine respond to an anti-racist curriculum. We emphasize that an environment of profound exchanges in the teaching–learning process, adopting anti-racism praxis as a competency in the medical curriculum, is a paradigm shift in medical education and future practice.
Experience of Online Learning from COVID-19: Preparing for the Future of Digital Transformation in Education
Authors: Jiang Bo , Li Xinya , Liu Sijiang , Hao Chuanyan , Zhang Gangyao , Lin Qiaomin
Published: December 2022

COVID-19 has affected traditional instructional activities. Home-based isolation and restrictive movement measures have forced most learning activities to move from an offline to an online environment. Multiple studies have also demonstrated that teaching with virtual tools during the COVID-19 pandemic is always ineffective. This study examines the different characteristics and challenges that virtual tools brought to online education in the pre-pandemic and pandemic era, with the aim of providing experience of how virtual tools supported purely online learning during a health crisis. By searching keywords in public databases and review publications, this study tries to summarize the major topics related to the research theme. These topics are the characteristics of learning supported by technologies in pre-pandemic and pandemic era, the challenges that education systems have faced during the COVID-19 pandemic. This study also compares the functions, advantages and limitations of typical virtual tools, which has rarely been done in previous studies. This study tries to present the features of virtual tools that support online learning and the challenges regarding real-life risk scenarios, and tries to provide educational institutions with a distinct perspective for efficient teaching and learning in future potential health crises.
Low-Temperature Reduction Synthesis of γ–Fe2O3−x@biochar Catalysts and Their Combining with Peroxymonosulfate for Quinclorac Degradation
Authors: Zhong Mei-e , Tong Gongsong , Sun Jingchun , Zhou Nan , Ding Chunxia , Liu Xiangying , Merchant Austin , Zhou Xuguo
Published: December 2022

Biochar loading mixed–phase iron oxide shows great advantages as a promising catalyst owing to its eco–friendliness and low cost. Here, γ–Fe2O3−x@biochar (E/Fe–N–BC) composite was successfully prepared by the sol–gel method combined with low–temperature (280 °C) reduction. The Scanning Electron Microscope (SEM) result indicated that γ–Fe2O3−x particles with the size of approximately 200 nm were well–dispersed on the surface of biochar. The CO derived from biomass pyrolysis is the main reducing component for the generation of Fe (II). The high content of Fe (II) contributed to the excellent catalytic performance of E/Fe–N–BC for quinclorac (QNC) degradation in the presence of peroxymonosulfate (PMS). The removal efficiency of 10 mg/L of QNC was 100% within 30 min using 0.3 g/L γ–Fe2O3−x@biochar catalyst and 0.8 mM PMS. The radical quenching experiments and electron paramagnetic resonance analysis confirmed that •OH and SO4•− were the main radicals during the degradation of QNC. The facile and easily mass–production of γ–Fe2O3−x@biochar with high catalytic activity make it a promising catalyst to activate PMS for the removal of organic pollutants.
Human Breast Milk Contamination with Aflatoxins, Impact on Children’s Health, and Possible Control Means: A Review
Authors: Benkerroum Noreddine , Ismail Amir
Published: December 2022

Aflatoxins are natural toxicants produced mainly by species of the Aspergillus genus, which contaminate virtually all feeds and foods. Apart from their deleterious health effects on humans and animals, they can be secreted unmodified or carried over into the milk of lactating females, thereby posing health risks to suckling babies. Aflatoxin M1 (AFM1) is the major and most toxic aflatoxin type after aflatoxin B1 (AFB1). It contaminates human breast milk upon direct ingestion from dairy products or by carry-over from the parent molecule (AFB1), which is hydroxylated in the liver and possibly in the mammary glands by cytochrome oxidase enzymes and then excreted into breast milk as AFM1 during lactation via the mammary alveolar epithelial cells. This puts suckling infants and children fed on this milk at a high risk, especially that their detoxifying activities are still weak at this age essentially due to immature liver as the main organ responsible for the detoxification of xenobiotics. The occurrence of AFM1 at toxic levels in human breast milk and associated health conditions in nursing children is well documented, with developing countries being the most affected. Different studies have demonstrated that contamination of human breast milk with AFM1 represents a real public health issue, which should be promptly and properly addressed to reduce its incidence. To this end, different actions have been suggested, including a wider and proper implementation of regulatory measures, not only for breast milk but also for foods and feeds as the upstream sources for breast milk contamination with AFM1. The promotion of awareness of lactating mothers through the organization of training sessions and mass media disclosures before and after parturition is of a paramount importance for the success of any action. This is especially relevant that there are no possible control measures to ensure compliance of lactating mothers to specific regulatory measures, which can yet be appropriate for the expansion of breast milk banks in industrialized countries and emergence of breast milk sellers. This review attempted to revisit the public health issues raised by mother milk contamination with AFM1, which remains undermined despite the numerous relevant publications highlighting the needs to tackle its incidence as a protective measure for the children physical and mental health.
Spatial and Attribute Neural Network Weighted Regression for the Accurate Estimation of Spatial Non-Stationarity
Authors: Ni Sihan , Wang Zhongyi , Wang Yuanyuan , Wang Minghao , Li Shuqi , Wang Nan
Published: December 2022

Geographically neural network weighted regression is an improved model of GWR combined with a neural network. It has a stronger ability to fit nonlinear functions, and complex geographical processes can be modeled more fully. GNNWR uses the distance metric of Euclidean space to express the relationship between sample points. However, except for spatial location features, geographic entities also have many diverse attribute features. Incorporating attribute features into the modeling process can make the model more suitable for the real geographical process. Therefore, we proposed a spatial-attribute proximities deep neural network to aggregate data from the spatial feature and attribute feature, so that one unified distance metric can be used to express the spatial and attribute relationships between sample points at the same time. Based on GNNWR, we designed a spatial and attribute neural network weighted regression (SANNWR) model to adapt to this new unified distance metric. We developed one case study to examine the effectiveness of SANNWR. We used PM2.5 concentration data in China as the research object and compared the prediction accuracy between GWR, GNNWR and SANNWR. The results showed that the “spatial-attribute” unified distance metric is useful, and that the SANNWR model showed the best performance.
Research on Gridding of Urban Spatial Form Based on Fractal Theory
Authors: Fan Qindong , Mei Xuejian , Zhang Chenming , Yang Xiaoyu
Published: December 2022

Urban spatial form is a significant reference to getting to know cities and running the cities. The fractal theory is an effective means to quantify urban spatial form. Taking the buildings in the outer ring of Zhengzhou City as the research object, the basic architectural models are built by extracting their forms. The research site is subdivided into 199 regions. The distribution of architectural forms in Zhengzhou is analyzed by fractal theory and spatial autocorrelation from the perspective of two-dimensional(2D) and three-dimensional(3D). The results indicate that the architectural layout of Zhengzhou has distinct fractal characteristics; Both global spatial autocorrelation and local spatial autocorrelation show significant positive correlations; There are obvious spatial differences in architectural space forms in different regions. The refined grid analysis strengthens the understanding of the urban spatial structure and development rules in more detail. The study promotes the refinement and visualization of fractal theory effectively and improves the depth of urban spatial form cognition.
The N6-Methyladenosine Regulator ALKBH5 Mediated Stromal Cell–Macrophage Interaction via VEGF Signaling to Promote Recurrent Spontaneous Abortion: A Bioinformatic and In Vitro Study
Authors: Zhao Yongbo , Sun Jiani , Jin Liping
Published: December 2022

Successful conception requires the synchrony of multiple systems and organs. Dysregulation of stromal cell–immune cell interactions has been proposed to be associated with recurrent spontaneous abortion. However, the mechanism of this regulation has not been well elucidated. N6-methyladenosine is one of the most common RNA modifications, and is involved in many pathological processes. Our group has demonstrated that abnormal patterns of m6A modification inhibit trophoblast invasion and contribute to adverse pregnancy outcomes. The association between m6A regulators and stromal cell–immune cell interactions is unclear. We obtained RNA-seq profiles from a GEO dataset and identified differentially expressed m6A regulators between healthy controls and patients with a recurrent spontaneous abortion history. ROC curves, functional enrichment and subclassification analysis were applied to elucidate the role of m6A regulators in pregnancy. We verified the expression of m6A regulators and constructed an overexpression cell line in a coculture system to reveal ALKBH5 function in stromal cell–macrophage interactions. We identified 11 differentially expressed m6A regulators between healthy controls and patients with a recurrent spontaneous abortion history. Then, we identified the correlation between “eraser” genes and “writer” genes. We tested the predictive abilities of the 11 m6A regulators based on another dataset and verified their expression in primary human endometrial stromal cells. We then subclassified three distinct patterns using the 11 genes and visualized genes related to immune infiltration and macrophage function in each cluster. ALKBH5 was proven to be correlated with recurrent spontaneous abortion. To verify the role of ALKBH5 in RSA, we constructed an ALKBH5-overexpression cell line. Finally, we cocultured the overexpression cell line with THP-1 cells. A decrease in M2 differentiation was observed, and this bias could be attributed to the hyposecretion of VEGF in stromal cells. N6-methyladenosine regulators play a pivotal role in stromal cell–immune cell interactions at the maternal–fetal interface. Overexpression of the m6A “eraser” gene ALKBH5 in stromal cells resulted in the hyposecretion of VEGF. Dysregulation of VEGF might impair macrophage recruitment and M2 differentiation, which could be the potential cause of recurrent spontaneous abortion.
Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies
Authors: Sounbuli Khetam , Mironova Nadezhda , Alekseeva Ludmila
Published: December 2022

Neutrophils represent the most abundant cell type of leukocytes in the human blood and have been considered a vital player in the innate immune system and the first line of defense against invading pathogens. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. They exhibited both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Neutrophils can be divided into several subpopulations, thus contradicting the traditional concept of neutrophils as a homogeneous population with a specific function in the innate immunity and opening new horizons for cancer therapy. Despite the promising achievements in this field, a full understanding of tumor–neutrophil interplay is currently lacking. In this review, we try to summarize the current view on neutrophil heterogeneity in cancer, discuss the different communication pathways between tumors and neutrophils, and focus on the implementation of these new findings to develop promising neutrophil-based cancer therapies.
Molecular Mechanisms of Alzheimer’s Disease III
Authors: Macreadie Ian G.
Published: December 2022

This Special Issue of IJMS is the third in the series: Molecular Mechanisms of Alzheimer’s Disease [...]
Antimicrobial Peptide Octominin-Encapsulated Chitosan Nanoparticles Enhanced Antifungal and Antibacterial Activities
Authors: Jayathilaka E. H. T. Thulshan , Nikapitiya Chamilani , De Zoysa Mahanama , Whang Ilson
Published: December 2022

Antimicrobial peptides (AMPs) have become a key solution for controlling multi-drug-resistant (MDR) pathogens, and the nanoencapsulation of AMPs has been used as a strategy to overcome challenges, such as poor stability, adverse interactions, and toxicity. In previous studies, we have shown the potent antimicrobial activity of Octominin against Candida albicans and Acinetobacter baumannii. This study is focused on the nanoencapsulation of Octominin with chitosan (CS) and carboxymethyl chitosan (CMC) as a drug delivery system using the ionotropic gelation technique. Octominin-encapsulated CS nanoparticles (Octominin-CNPs) had an average diameter and zeta potential of 372.80 ± 2.31 nm and +51.23 ± 0.38 mV, respectively, while encapsulation efficiency and loading capacity were 96.49 and 40.20%, respectively. Furthermore, Octominin-CNPs showed an initial rapid and later sustained biphasic release profile, and up to 88.26 ± 3.26% of the total Octominin release until 96 h. Transmission electron microscopy data showed the irregular shape of the Octominin-CNPs with aggregations. In vitro and in vivo toxicity of Octominin-CNPs was significantly lower than the Octominin at higher concentrations. The antifungal and antibacterial activities of Octominin-CNPs were slightly higher than those of Octominin in both the time-kill kinetic and microbial viability assays against C. albicans and A. baumannii, respectively. Mode of action assessments of Octominin-CNPs revealed that morphological alterations, cell membrane permeability alterations, and reactive oxygen species generation were slightly higher than those of Octominin at the tested concentrations against both C. albicans and A. baumannii. In antibiofilm activity assays, Octominin-CNPs showed slightly higher biofilm inhibition and biofilm eradication activities compared to that of Octominin. In conclusion, Octominin was successfully encapsulated into CS, and Octominin-CNPs showed lower toxicity and greater antimicrobial activity against C. albicans and A. baumannii compared to Octominin.
Treatment of Cesarean Scar Ectopic Pregnancy in China with Uterine Artery Embolization—A Systematic Review and Meta-Analysis
Authors: Marchand Greg J. , Masoud Ahmed Taher , Coriell Catherine , Ulibarri Hollie , Parise Julia , Arroyo Amanda , Goetz Sydnee , Moir Carmen , Moberly Atley , Govindan Malini
Published: December 2022

Cesarean scar ectopic pregnancy (CSP) is a rare form of ectopic pregnancy, and treatment of CSP with uterine artery embolization (UAE) is a novel approach. With increasing numbers of cesarean sections being performed annually, the incidence of this condition is likely to increase. The authors became aware of an unusually high number of published studies originating in mainland China regarding this unusual treatment and sought to perform a meta-analysis to provide comprehensive evidence on this novel practice. Methods: We performed a thorough search and included all forms of quality studies on this topic that reported UAE as a part of first-line management of CSP. We included only studies originating in China. Ultimately, 37 studies were included for qualitative and quantitative synthesis of evidence. After screening retrieved records and extracting data from eligible studies, we pooled continuous data as a mean estimate and 95% confidence interval (CI), and dichotomous data as proportion and 95% CI. Results: CSP patients treated with protocols including UAE had a mean time of 30 days for serum β-hCG normalization, 95% CI [26.816, 33.881]. They had a mean estimated intraprocedural blood loss of 4.19 ± 3.76 mL, a mean hospital stay of nine days, 95%CI [7.914, 9.876], and a success rate of 93.4%, 95%CI [0.918, 0.951]. The severe complication rate was 1.2%, 95%CI [0.008, 0.017]. Conclusion: UAE, in combination with other procedures is being used effectively for the treatment of CSP in China. Protocols including UAE have a success rate of approximately 93.4%, and a severe complication rate of approximately 1.2%. This data’s utility is limited by vast differences in the studied protocols and questionable feasibility outside of China.
NT-pro-BNP as a Predictor for Recurrence of Atrial Fibrillation after Primary Cryoballoon Pulmonary Vein Isolation
Authors: Blessberger Hermann , Lambert Thomas , Nahler Alexander , Hrncic Denis , Hönig Simon , Maier Julian , Rechberger Stefan , Windhager Armin , Reiter Christian , Kellermair Joerg , Kammler Juergen , Wagner Helga , Steinwender Clemens
Published: December 2022

NT-pro-BNP is produced in the cardiac atria and ventricles in response to increased wall stress. It may be a marker of both AF disease progression and co-morbidities that affect success after pulmonary vein isolation (PVI). This single-center retrospective study analyzed the association between pre-procedural NT-pro-BNP serum levels and the long-term outcome after a first-ever PVI in cryo-technique. Patients were followed by searching the hospital information system and conducting structured telephone interviews. Treatment failure was defined as any relapse of atrial fibrillation (AF) occurring 90 days after the index PVI at the earliest. Kaplan–Meier survival curves and Cox proportional hazards models were computed to assess the impact of NT-pro-BNP on AF recurrence. Following 374 patients over a median of 3.8 years (range: 0.25–9.4 years), baseline NT-pro-BNP was associated with the combined endpoint in univariate analysis (HR 1.04 per 100 pg/mL increase, 95% CI: 1.02–1.07, p < 0.001). Results were virtually unchanged in the multivariate model or if the data were log-transformed. Intraprocedural left atrial pressure correlated positively with log NT-pro-BNP. NT-pro-BNP was associated with AF relapse during a long-term follow-up after first-ever cryo-PVI in our cohort of patients with predominantly normal left ventricular function. This lab parameter is easy to obtain and has significant potential to guide treatment decisions.
Central versus Peripheral Postcardiotomy Veno-Arterial Extracorporeal Membrane Oxygenation: Systematic Review and Individual Patient Data Meta-Analysis
Authors: Biancari Fausto , Kaserer Alexander , Perrotti Andrea , Ruggieri Vito G. , Cho Sung-Min , Kang Jin Kook , Dalén Magnus , Welp Henryk , Jónsson Kristján , Ragnarsson Sigurdur , Hernández Pérez Francisco J. , Gatti Giuseppe , Alkhamees Khalid , Loforte Antonio , Lechiancole Andrea , Rosato Stefano , Spadaccio Cristiano , Pettinari Matteo , Fiore Antonio , Mäkikallio Timo , Sahli Sebastian D. , L’Acqua Camilla , Arafat Amr A. , Albabtain Monirah A. , AlBarak Mohammed M. , Laimoud Mohamed , Djordjevic Ilija , Krasivskyi Ihor , Samalavicius Robertas , Puodziukaite Lina , Alonso-Fernandez-Gatta Marta , Wilhelm Markus J. , Mariscalco Giovanni
Published: December 2022

Background: It is unclear whether peripheral arterial cannulation is superior to central arterial cannulation for postcardiotomy veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Methods: A systematic review was conducted using PubMed, Scopus, and Google Scholar to identify studies on postcardiotomy VA-ECMO for the present individual patient data (IPD) meta-analysis. Analysis was performed according to the intention-to-treat principle. Results: The investigators of 10 studies agreed to participate in the present IPD meta-analysis. Overall, 1269 patients were included in the analysis. Crude rates of in-hospital mortality after central versus peripheral arterial cannulation for VA-ECMO were 70.7% vs. 63.7%, respectively (adjusted OR 1.38, 95% CI 1.08–1.75). Propensity score matching yielded 538 pairs of patients with balanced baseline characteristics and operative variables. Among these matched cohorts, central arterial cannulation VA-ECMO was associated with significantly higher in-hospital mortality compared to peripheral arterial cannulation VA-ECMO (64.5% vs. 70.8%, p = 0.027). These findings were confirmed by aggregate data meta-analysis, which showed that central arterial cannulation was associated with an increased risk of in-hospital mortality compared to peripheral arterial cannulation (OR 1.35, 95% CI 1.04–1.76, I2 21%). Conclusions: Among patients requiring postcardiotomy VA-ECMO, central arterial cannulation was associated with an increased risk of in-hospital mortality compared to peripheral arterial cannulation. This increased risk is of limited magnitude, and further studies are needed to confirm the present findings and to identify the mechanisms underlying the potential beneficial effects of peripheral VA-ECMO.
Primary Cilia Dysfunction in Neurodevelopmental Disorders beyond Ciliopathies
Authors: Karalis Vasiliki , Donovan Kathleen E. , Sahin Mustafa
Published: December 2022

Primary cilia are specialized, microtubule-based structures projecting from the surface of most mammalian cells. These organelles are thought to primarily act as signaling hubs and sensors, receiving and integrating extracellular cues. Several important signaling pathways are regulated through the primary cilium including Sonic Hedgehog (Shh) and Wnt signaling. Therefore, it is no surprise that mutated genes encoding defective proteins that affect primary cilia function or structure are responsible for a group of disorders collectively termed ciliopathies. The severe neurologic abnormalities observed in several ciliopathies have prompted examination of primary cilia structure and function in other brain disorders. Recently, neuronal primary cilia defects were observed in monogenic neurodevelopmental disorders that were not traditionally considered ciliopathies. The molecular mechanisms of how these genetic mutations cause primary cilia defects and how these defects contribute to the neurologic manifestations of these disorders remain poorly understood. In this review we will discuss monogenic neurodevelopmental disorders that exhibit cilia deficits and summarize findings from studies exploring the role of primary cilia in the brain to shed light into how these deficits could contribute to neurologic abnormalities.
The Iron Age Necropolis of El Toro (Alcubillas, Ciudad Real-Spain)—Combination of Archaeological and Geophysical Techniques with Ground Penetrating Radar in the Area around the Jabalón River
Authors: Catalán González Francisco Javier , Benítez de Lugo Enrich Luis , Ruiz Gil José Antonio , Rondán Sevilla Isabel
Published: December 2022

The necropolis of El Toro is characterised as a space of prolonged use in northern Oretania. Several important archaeological finds were made in 1975 and 2012, leading to the excavation of six test pits in 2017. Based on the existing legacy data, an extension of the state of knowledge was carried out by combining several geophysical tools. The geophysical tools chosen for this sample consist of a combination of data from two different georadar systems, to which data from a magnetometer survey is added. A series of post-processes are applied to the preliminary results to improve the visualisation and interpretation of the data. The combination of these techniques used at the site is an improvement that helps us to understand these spaces and their interaction with the historical landscape of La Mancha.
Erosive Pustular Dermatosis: Delving into Etiopathogenesis and Management
Authors: Bhargava Shashank , Yumeen Sara , Henebeng Esther , Kroumpouzos George
Published: December 2022

Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that usually affects mature individuals. It predominantly affects the scalp and can lead to scarring alopecia. Risk factors include actinic damage and androgenetic alopecia. A traumatic insult to the skin is considered a vital trigger of the condition. EPD is a diagnosis of exclusion; thus, several neoplastic, infectious, vesiculobullous, and inflammatory conditions should be ruled out. Biopsy and clinicopathologic correlation are required to differentiate between EPD and these entities. A dysregulated, chronic immune response is considered central to the etiopathogenesis of EPD. We performed an evidence-based systematic review of the management options. There were predominantly studies with level IV and V evidence and only two with level III. Despite the responsiveness of EPD to potent topical steroids, such as clobetasol propionate, recurrence occurs after treatment withdrawal. With the available data, tacrolimus 0.1%, curettage-assisted aminolevulinic acid-photodynamic therapy, and systemic retinoids can be considered second-line options for EPD with a role in maintenance regimens. However, controlled data and more powerful studies are needed to make solid recommendations.
Modeling of the Achilles Subtendons and Their Interactions in a Framework of the Absolute Nodal Coordinate Formulation
Authors: Obrezkov Leonid P. , Finni Taija , Matikainen Marko K.
Published: December 2022

Experimental results have revealed the sophisticated Achilles tendon (AT) structure, including its material properties and complex geometry. The latter incorporates a twisted design and composite construction consisting of three subtendons. Each of them has a nonstandard cross-section. All these factors make the AT deformation analysis computationally demanding. Generally, 3D finite solid elements are used to develop models for AT because they can discretize almost any shape, providing reliable results. However, they also require dense discretization in all three dimensions, leading to a high computational cost. One way to reduce degrees of freedom is the utilization of finite beam elements, requiring only line discretization over the length of subtendons. However, using the material models known from continuum mechanics is challenging because these elements do not usually have 3D elasticity in their descriptions. Furthermore, the contact is defined at the beam axis instead of using a more general surface-to-surface formulation. This work studies the continuum beam elements based on the absolute nodal coordinate formulation (ANCF) for AT modeling. ANCF beam elements require discretization only in one direction, making the model less computationally expensive. Recent work demonstrates that these elements can describe various cross-sections and materials models, thus allowing the approximation of AT complexity. In this study, the tendon model is reproduced by the ANCF continuum beam elements using the isotropic incompressible model to present material features.
Investigation of Soft Magnetic Material Fe-6.5Si Fracture Obtained by Additive Manufacturing
Authors: Agapovichev Anton V. , Khaimovich Alexander I. , Erisov Yaroslav A. , Ryazanov Mikhail V.
Published: December 2022

The freeform capability additive manufacturing (AM) technique and the magnetic efficiency of Fe-6.5Si steel have the potential for the development of electromechanical component designs with thin body sections. Moreover, the directional anisotropy of the material, which is formed during growth, improves the magnetic and electrical properties of Fe-6.5 wt%Si. We obtained the range of optimal technological modes of Laser Power Bed Fusion process (volume energy density (VED) of 100–140 J/mm3, scanning speed of 750–500 mm/s) to produce the samples from Fe-6.5 wt%Si powder, but even at the best of them cracks may appear. The optical microscopy and SEM with EDX analysis of the laser-fabricated structures are applied for investigation of this phenomena. We detected a carbon content at the boundaries of the cracks. This suggests that one of the reasons for the crack formation is the presence of Fe3C in the area of the ordered α’FeSi (B2)+Fe3Si(D03) phases. Quantitative analysis based on crack initiation criteria (CIC) showed that the safe level of internal stresses in terms of the CIC criteria in the area of discontinuities is exceeded by almost 190%. Local precipitates of carbides in the area of cracks are explained by the heterogeneity and high dynamics of temperature fields, as well as the transfer of substances due to Marangoni convection, which, as a result, contributes to a significant segregation of elements and the formation of precipitate phases.
Experimental Investigation of Pre-Flawed Rocks under Dynamic Loading: Insights from Fracturing Characteristics and Energy Evolution
Authors: Zhao Guifeng , Zhang Lei , Dai Bing , Liu Yong , Zhang Zhijun , Luo Xinyao
Published: December 2022

Different fractures exist widely in rock mass and play a significant role in their deformation and strength properties. Crack rocks are often subjected to dynamic disturbances, which exist in many fields of geotechnical engineering practices. In this study, dynamic compression tests were carried out on rock specimens with parallel cracks using a split hopkinson pressure bar apparatus. Tests determined the effects of strain rate and crack intensity on dynamic responses, including progressive failure behavior, rock fragmentation characteristics, and energy dissipation. Based on the crack classification method, tensile–shear mixed cracking dominates the failure of rock specimens under the action of impact loading. Increasing the flaw inclination angle from 0°–90° changes the predominant cracking mechanism from tensile cracking to mixed tensile–shear cracking. The larger the loading rate, the more obvious the cracking mechanism, which indicates that the loading rate can promote the cracking failure of rock specimens. The fragmentation analysis shows that rock samples are significantly broken at higher loading rates, and higher loading rates lead to smaller average fragment sizes; therefore, the larger the fractal dimension is, the more uniform the broken fragments of smaller sizes are. Energy utilization efficiency decreases while energy dissipation density increases with increasing strain rate. For a given loading rate, the energy absorption density and energy utilization efficiency first decrease and then increase with increasing flaw inclination, while the rockburst tendency of rock decreases initially and then increases. We also find that the elastic–plastic strain energy density increases linearly with the total input energy density, confirming that the linear energy property of granite has not been altered by the loading rate. According to this inherent property, the peak elastic strain energy of the crack specimen can be calculated accurately. On this basis, the rockburst proneness of granite can be determined quantitatively using the residual elastic energy index, and the result is consistent with the intensity of actual rockburst for the specimens.
Study on Microwave Deicing Efficiency of Microwave-Absorbing Concrete Pavements and Its Influencing Factors
Authors: Liu Mingyan , Wang Xuancang , Deng Yuyuan , Guo Yuchen , Zhao Jing , Li Meixin
Published: December 2022

Microwave deicing technology, as a new environmentally friendly deicing technology, can effectively solve the problem of the frequent icing of road surfaces in the winter, which affects the safety of traffic. To improve the efficiency of microwave deicing on cement concrete pavement, this study proposed the use of magnetite, iron sulfide slag, steel slag, lead–zinc slag, and graphite as microwave-absorbing materials, and conducted microwave deicing tests under the influence of five factors, namely the form of the pavement surface structure, the content of the microwave-absorbing material, microwave power, the shielding state, and dry and wet conditions. Layer by layer, we selected the combination of pavement surface structure, microwave-absorbing material content, microwave power, shielding state, and dry and wet conditions on the bottom surface of the concrete slab with the optimal deicing effect. The results showed that the 2 cm scattered microwave-absorbing surface concrete structure has the fastest heating rate; the higher the magnetite content and microwave power, the higher the deicing efficiency; the maximum heating rate can be increased by 17.6% when the shielding layer is set at the bottom of the cement concrete slab; and the heating rate of the microwave-absorbing concrete slab in the wet state is increased by 20.8% relative to the dry state. In summary, 7000 W of power, a magnetite content of 60 vol % in the scattered microwave-absorbing surface, a shielding layer set at the bottom surface, and wet conditions can greatly improve the efficiency of microwave deicing compared with the microwave ice melting effects of plain cement concrete and other microwave-absorbing materials mixed into the concrete. In addition, the temperature uniformity of the microwave-absorbing materials is essential to improve the deicing efficiency of microwave-absorbing concrete, so it is essential to explore it further.
A Survey on Newhouse Thickness, Fractal Intersections and Patterns
Authors: Yavicoli Alexia
Published: December 2022

In this article, we introduce a notion of size for sets, called the thickness, that can be used to guarantee that two Cantor sets intersect (the Gap Lemma) and show a connection among thickness, Schmidt games and patterns. We work mostly in the real line, but we also introduce the topic in higher dimensions.
Ionic Liquids-Polymer of Intrinsic Microporosity (PIMs) Blend Membranes for CO2 Separation
Authors: Ferraro Giuseppe , Astorino Carmela , Bartoli Mattia , Martis Alberto , Lettieri Stefania , Pirri Candido Fabrizio , Bocchini Sergio
Published: December 2022

Membranes with high CO2 solubility are essential for developing a separation technology with low carbon footprint. To this end, physical blend membranes of [BMIM][Ac] and [BMIM][Succ] as Ionic Liquids (ILs) and PIM-1 as the polymer were prepared trying to combine the high permeability properties of PIM-1 with the high CO2 solubility of the chosen ILs. Membranes with a PIM-1/[BMIM][Ac] 4/1 ratio nearly double their CO2 solubility at 0.8 bar (0.86 cm3 (STP)/cm3 cmHg), while other ratios still maintain similar solubilities to PIM-1 (0.47 cm3 (STP)/cm3 cmHg). Moreover, CO2 permeability of PIM-1/[BMIM][Ac] blended membranes were between 1050 and 2090 Barrer for 2/1 and 10/1 ratio, lower than PIM-1 membrane, but still highly permeable. The here presented self-standing and mechanically resistant blend membranes have yet a lower permeability compared to PIM-1 yet an improved CO2 solubility, which eventually will translate in higher CO2/N2 selectivity. These promising preliminary results will allow us to select and optimize the best performing PIM-1/ILs blends to develop outstanding membranes for an improved gas separation technology.
Flexible Heater Fabrication Using Amino Acid-Based Ink and Laser-Direct Writing
Authors: Koo Sangmo
Published: December 2022

Nature’s systems have evolved over a long period to operate efficiently, and this provides hints for metal nanoparticle synthesis, including the enhancement, efficient generation, and transport of electrons toward metal ions for nanoparticle synthesis. The organic material-based ink composed of the natural materials used in this study requires low laser power for sintering compared to conventional nanoparticle ink sintering. This suggests applicability in various and sophisticated pattern fabrication applications without incurring substrate damage. An efficient electron transfer mechanism between amino acids (e.g., tryptophan) enables silver patterning on flexible polymer substrates (e.g., PET) by laser-direct writing. The reduction of silver ions to nanoparticles was induced and sintered by simultaneous photo/thermalchemical reactions on substrates. Furthermore, it was possible to fabricate a stable, transparent, and flexible heater that operates under mechanical deformation.