bluuebunny/crossref_metadata_2025 huggingface dataset:
Community and People in Catholic Thought, 1830–1870
Authors: Romani Roberto
Published: November 2023

Far from being limited to denunciations of modernity, nineteenth-century Catholic thought had a programmatic and visionary side. This article deals with the models of community put forward by Lamennais inL'Avenir, Antonio Rosmini, Luigi Taparelli d'Azeglio, and Wilhelm Ketteler. These writers reimagined the foundations of public life against the claims of self-interested individualism and state omnipotence. Three theses in particular capture their vision of the future polity: 1) societies, which were not “mechanisms,” needed Catholicism as animating spirit; 2) political representation should be “organic”; and 3) whereas the liberal elites imposed their vested interests on the common people, the Catholic polity reflected their needs and beliefs. The four writers envisaged a community of the gentle and caring, which, like the family, was hierarchical, self-governed, local, and supportive. In contrast, it was argued that the people had no voice under liberalism because the elite's values were not the people's and because the political system was a mere arena for the clash of special interests. This was a communitarian and populist Catholicism, prizing self-government, denouncing parliamentary politics, and siding with “the people.”
Dietary interventions in pregnancy for the prevention of gestational diabetes: a literature review
Authors: Michalopoulou Moscho , Jebb Susan A. , Astbury Nerys M.
Published: November 2023

The aim of this review is to provide an overview of dietary interventions delivered during pregnancy for the prevention of gestational diabetes mellitus (GDM). GDM increases the risk of adverse pregnancy and neonatal outcomes, and also increases future cardiometabolic risks for both the mother and the offspring. Carrying or gaining excessive weight during pregnancy increases the risk of developing GDM, and several clinical trials in women with overweight or obesity have tested whether interventions aimed at limiting gestational weight gain (GWG) could help prevent GDM. Most dietary interventions have provided general healthy eating guidelines, while some had a specific focus, such as low glycaemic index, increased fibre intake, reducing saturated fat or a Mediterranean-style diet. Although trials have generally been successful in attenuating GWG, the majority have been unable to reduce GDM risk, which suggests that limiting GWG may not be sufficient in itself to prevent GDM. The trials which have shown effectiveness in GDM prevention have included intensive face-to-face dietetic support, and/or provision of key foods to participants, but it is unclear whether these strategies could be delivered in routine practice. The mechanism behind the effectiveness of some interventions over others remains unclear. Dietary modifications from early stages of pregnancy seem to be key, but the optimum dietary composition is unknown. Future research should focus on designing acceptable and scalable dietary interventions to be tested early in pregnancy in women at risk of GDM.
Novel detection of Leishmania RNA virus-1 (LRV-1) in clinical isolates of Leishmania Viannia panamensis
Authors: Kariyawasam Ruwandi , Lau Rachel , Valencia Braulio M. , Llanos-Cuentas Alejandro , Boggild Andrea K.
Published: November 2023

American tegumentary leishmaniasis comprises a discrete set of clinical presentations endemic to Latin America. Leishmania RNA virus-1 (LRV-1) is a double-stranded RNA virus identified in 20–25% of the Leishmania Viannia braziliensis and L. V. guyanensis, however not in L. V. panamensis. This is the first report of LRV-1 in L. V. panamensis and its associations with clinical phenotypes of ATL. Unique surplus discard clinical isolates of L. V. panamensis were identified from the Public Health Ontario Laboratory (PHOL) and the Leishmania Clinic of the Instituto de Medicina Tropical ‘Alexander von Humboldt’ between 2012 and 2019 and screened for LRV-1 by real-time polymerase chain reaction. Patient isolates were stratified according to clinical phenotype. Of 30 patients with L. V. panamensis, 14 (47%) and 16 (53%) patients had severe and non-severe ATL, respectively. Five (36%) of 14 severe cases and 2 (12%) of 16 non-severe cases were positive for LRV-1, respectively. No differences in sex were observed for clinical phenotype and LRV-1 status. Although an association between LRV-1 status and clinical phenotype was not demonstrated, this is the first description of the novel detection of LRV-1 in L. V. panamensis, a species that has been documented predominantly in Central America.
An outbreak of Salmonella Typhimurium associated with the consumption of raw liver at an Eid al-Adha celebration in Wales (UK), July 2021
Authors: Adamson James P. , Sawyer Clare , Hobson Gemma , Clark Emily , Fina Laia , Orife Oghogho , Smith Robert , Williams Chris , Hughes Harriet , Jones Allyson , Swaysland Sarah , Somoye Oluwaseun , Phillips Ryan , Iqbal Junaid , Mohammed Israa , Karani George , Thomas Daniel Rhys
Published: November 2023

In July 2021, Public Health Wales received two notifications of salmonella gastroenteritis. Both cases has attended the same barbecue to celebrate Eid al–Adha, two days earlier. Additional cases attending the same barbecue were found and an outbreak investigation was initiated. The barbecue was attended by a North African community’s social network. On same day, smaller lunches were held in three homes in the social network. Many people attended both a lunch and the barbecue. Cases were defined as someone with an epidemiological link to the barbecue and/or lunches with diarrhoea and/or vomiting with date of onset following these events. We undertook a cohort study of 36 people attending the barbecue and/or lunch, and a nested case-control study using Firth logistic regression. A communication campaign, sensitive towards different cultural practices, was developed in collaboration with the affected community. Consumption of a traditional raw liver dish, ‘marrara’, at the barbecue was the likely vehicle for infection (Firth logistic regression, aOR: 49.99, 95%CI 1.71–1461.54, p = 0.02). Meat and offal came from two local butchers (same supplier) and samples yielded identical whole genome sequences as cases. Future outbreak investigations should be relevant to the community affected by considering dishes beyond those found in routine questionnaires.
All that flows across the ventricular septum are not ventricular septal defects
Authors: Mondal Sudipta , Raja Dinesh P. , Gopalakrishnan Arun
Published: November 2023

Coronary cameral fistula is a rare congenital anomaly and clinical presentation depends on the location of the defect, degree of shunting, and associated complications. We present a case of coronary cameral fistula where segmental analysis by echocardiogram helped us to avoid misdiagnosis as a ventricular septal defect.
EMS Responses for Pediatric Behavioral Health Emergencies in the United States: A 4-Year Descriptive Evaluation
Authors: Boland Lori L. , Anderson Morgan K. , Powell Jonathan R. , Patock Michael T. , Panchal Ashish R.
Published: November 2023

Background:

The occurrence of behavioral health emergencies (BHEs) in children is increasing in the United States, with patient presentations to Emergency Medical Services (EMS) behaving similarly. However, detailed evaluations of EMS encounters for pediatric BHEs at the national level have not been reported.

Methods:

This was a secondary analysis of a national convenience sample of EMS electronic patient care records (ePCRs) collected from January 1, 2018 through December 31, 2021. Inclusion criteria were all EMS activations documented as 9-1-1 responses involving patients < 18 years of age with a primary or secondary provider impression of a BHE. Patient demographics, incident characteristics, and clinical variables including administration of sedation medications, use of physical restraint, and transport status were examined overall and by calendar year.

Results:

A total of 1,079,406 pediatric EMS encounters were present in the dataset, of which 102,014 (9.5%) had behavioral health provider impressions. Just over one-half of BHEs occurred in females (56.2%), and 68.1% occurred in patients aged 14-17 years. Telecommunicators managing the 9-1-1 calls for these events reported non-BHE patient complaints in 34.7%. Patients were transported by EMS 68.9% of the time, while treatment and/or transport by EMS was refused in 12.5%. Prehospital clinicians administered sedation medications in 1.9% of encounters and applied physical restraints in 1.7%. Naloxone was administered for overdose rescue in 1.5% of encounters.

Conclusion:

Approximately one in ten pediatric EMS encounters occurring in the United States involve a BHE, and the majority of pediatric BHEs attended by EMS result in transport of the child. Use of sedation medications and physical restraints by prehospital clinicians in these events is rare. National EMS data from a variety of sources should continue to be examined to monitor trends in EMS encounters for BHEs in children.
Anisotropic Velocity Structure Beneath Shikoku, Japan: Insights From Receiver Function and Shear Wave Splitting Analyses
Authors: Ruan Yihuan , Ito Yoshihiro , Sawaki Yasunori
Published: November 2023

A combination of receiver function (RF) analysis and shear wave splitting can reveal the anisotropic properties of the Earth's velocity structure. The RF profile exhibits harmonic patterns partially generated from the discontinuities of anisotropic media near the receiver. The anisotropic properties are determined using splitting parameters, which include the fast polarization direction (FPD) and split time. We utilized the seismograms recorded by stations on Shikoku Island, Japan. Also, we applied the Bayesian information criterion to control the spike count of each RF, which consists of a series of spikes generated by time‐domain iterative deconvolution. Anisotropic differences arose between northern and southern regions along the 30‐km iso‐depth line of the top surface of the Philippine Sea Plate. In the southern part of Shikoku Island, the FPDs are sub‐perpendicular to the plunge of the subducting slab, while in the northern part, they are sub‐parallel to the plunge of the slab. Our results indicate that anisotropic strengths are weaker in the tectonic‐tremor band in northwestern Shikoku and stronger in the northern part of central and eastern Shikoku around the no tectonic‐tremor area. These anisotropic variations may characterize Shikoku Island’s geological structure.
Effects of Pore Geometry and Saturation on the Behavior of Multiscale Waves in Tight Sandstone Layers
Authors: Ba Jing , Ma Rupeng , Carcione José M. , Shi Ying , Zhang Lin
Published: November 2023

Geometric heterogeneities in tight reservoir rocks saturated with a fluid mixture may exhibit different scale distribution characteristics. Conventional models of rock physics based on poroelasticity, which usually consider single‐scale pore structure and fluid patches, are inadequate for describing elastic wave responses. A major challenge is to establish the relationship between the wave response at different spatial scales and frequencies. To address this problem, three sets of observational data over a wide frequency range were obtained from a tight oil reservoir in the Ordos Basin, China. Ultrasonic measurements were made on eight sandstone samples at partial oil‐water saturation at 0.55 MHz. Data from six borehole measurements and seismic profiles were acquired and analyzed at about 10 kHz and 30 Hz, respectively. Analysis of the cast thin sections shows that dissolution pores and microcracks generally develop, with fractal dimensions of the pores ranging from 2.45 to 2.67 for the samples with porosities between 5.1% and 10.2%. Compressional wave velocity and attenuation were estimated from the observed data. The results show that the velocity dispersion from seismic to ultrasonic frequencies is 10.02%, mostly occurring between sonic and ultrasonic frequencies. The attenuation is stronger at higher oil saturation. The relationships between velocity, attenuation, and wavelength were established and can be used for further forward modeling and seismic interpretation studies. A partial saturation model has been derived based on effective differential medium theory and a double double‐porosity model, assuming that the medium contains fractal cracks and fluid patches. The effects of scale and saturation on wave responses are prevalent. Modeling results consistent with observed data show that the radii of cracks and fluid patches range from 0.1 μm to 2.8 mm, affecting ultrasonic, acoustic, and seismic attenuation. The multiscale data and proposed model quantify the relationship between fracture and fluid distributions and attenuation and could be useful for upscaling to the reservoir scale. The study helps improve the understanding of seismic wave propagation in partially saturated rocks, which has potential applications in seismic exploration, hydrocarbon production in reservoirs, and CO2 sequestration in aquifers.
High‐Latitude, Indian Ocean, and Orbital Influences on Eastern African Hydroclimate Across the Plio‐Pleistocene Boundary
Authors: Mitsunaga Bryce A. , Lupien Rachel L. , Ouertani Samantha , Stubbs Brandon , Deino Alan L. , Kingston John D. , Stockhecke Mona , Brown Erik T. , Russell James M.
Published: November 2023

Terrestrial‐marine dust fluxes, pedogenic carbonate δ13C values, and various paleovegetation proxies suggest that Africa experienced gradual cooling and drying across the Pliocene‐Pleistocene (Plio‐Pleistocene) boundary (2.58 million years ago [Ma]). However, the timing, magnitude, resolution, and relative influences of orbitally‐driven changes in high latitude glaciations and low latitude insolation differ by region and proxy. To disentangle these forcings and investigate equatorial eastern African climate across the Plio‐Pleistocene boundary, we generated a high‐resolution (∼3,000‐year) data set of compound‐specific n‐alkane leaf wax δ2H values—a robust proxy for atmospheric circulation and precipitation amount—from the HSPDP‐BTB13‐1A core, which spans a ∼3.3–2.6 Ma sequence in the Baringo‐Tugen Hills‐Barsemoi Basin of central Kenya. In combination with the physical sedimentology, our data indicate that precipitation varied strongly with orbital obliquity, not precession, during the late Pliocene, perhaps imparted by variations in the cross‐equatorial insolation gradient. We also observe a marked shift toward wetter conditions beginning ∼3 Ma that corresponds with global cooling, drying in western Australia, and a steepening of the west‐east zonal Indian Ocean (IO) sea surface temperature (SST) gradient. We propose that northward migration of the Subtropical Front reduced Agulhas current leakage, warming the western IO and causing changes in the IO zonal SST gradient at 3 Ma, a process that has been observed in the latest Pleistocene‐Holocene but not over longer timescales. Thus, the late Cenozoic moisture history of eastern Africa is driven by a complex mixture of low‐latitude insolation, the IO SST gradient, and teleconnections to distal high‐latitude cooling.
Geophysics‐Informed Hydrologic Modeling of a Mountain Headwater Catchment for Studying Hydrological Partitioning in the Critical Zone
Authors: Chen Hang , Niu Qifei , Mendieta Aida , Bradford John , McNamara James
Published: November 2023

Hydrologic modeling has been a useful approach for analyzing water partitioning in catchment systems. It will play an essential role in studying the responses of watersheds under projected climate changes. Numerous studies have shown it is critical to include subsurface heterogeneity in the hydrologic modeling to correctly simulate various water fluxes and processes in the hydrologic system. In this study, we test the idea of incorporating geophysics‐obtained subsurface critical zone (CZ) structures in the hydrologic modeling of a mountainous headwater catchment. The CZ structure is extracted from a three‐dimensional seismic velocity model developed from a series of two‐dimensional velocity sections inverted from seismic travel time measurements. Comparing different subsurface models shows that geophysics‐informed hydrologic modeling better fits the field observations, including streamflow discharge and soil moisture measurements. The results also show that this new hydrologic modeling approach could quantify many key hydrologic fluxes in the catchment, including streamflow, deep infiltration, and subsurface water storage. Estimations of these fluxes from numerical simulations generally have low uncertainties and are consistent with estimations from other methods. In particular, it is straightforward to calculate many hydraulic fluxes or states that may not be measured directly in the field or separated from field observations. Examples include quickflow/subsurface lateral flow, soil/rock moisture, and deep infiltration. Thus, this study provides a useful approach for studying the hydraulic fluxes and processes in the deep subsurface (e.g., weathered bedrock), which needs to be better represented in many earth system models.
Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival
Authors: Simhal Anish K. , Maclachlan Kylee H. , Elkin Rena , Zhu Jiening , Norton Larry , Deasy Joseph O. , Oh Jung Hun , Usmani Saad Z. , Tannenbaum Allen
Published: November 2023

The plasma cell cancer multiple myeloma (MM) varies significantly in genomic characteristics, response to therapy, and long-term prognosis. To investigate global interactions in MM, we combined a known protein interaction network with a large clinically annotated MM dataset. We hypothesized that an unbiased network analysis method based on large-scale similarities in gene expression, copy number aberration, and protein interactions may provide novel biological insights. Applying a novel measure of network robustness, Ollivier-Ricci Curvature, we examined patterns in the RNA-Seq gene expression and CNA data and how they relate to clinical outcomes. Hierarchical clustering using ORC differentiated high-risk subtypes with low progression free survival. Differential gene expression analysis defined 118 genes with significantly aberrant expression. These genes, while not previously associated with MM, were associated with DNA repair, apoptosis, and the immune system. Univariate analysis identified 8/118 to be prognostic genes; all associated with the immune system. A network topology analysis identified both hub and bridge genes which connect known genes of biological significance of MM. Taken together, gene interaction network analysis in MM uses a novel method of global assessment to demonstrate complex immune dysregulation associated with shorter survival.
Volcaniclastic density currents explain widespread and diverse seafloor impacts of the 2022 Hunga Volcano eruption
Authors: Seabrook Sarah , Mackay Kevin , Watson Sally J. , Clare Michael A. , Hunt James E. , Yeo Isobel A. , Lane Emily M. , Clark Malcolm R. , Wysoczanski Richard , Rowden Ashley A. , Kula Taaniela , Hoffmann Linn J. , Armstrong Evelyn , Williams Michael J. M.
Published: November 2023

The impacts of large terrestrial volcanic eruptions are apparent from satellite monitoring and direct observations. However, more than three quarters of all volcanic outputs worldwide lie submerged beneath the ocean, and the risks they pose to people, infrastructure, and benthic ecosystems remain poorly understood due to inaccessibility and a lack of detailed observations before and after eruptions. Here, comparing data acquired between 2015 - 2017 and 3 months after the January 2022 eruption of Hunga Volcano, we document the far-reaching and diverse impacts of one of the most explosive volcanic eruptions ever recorded. Almost 10 km3of seafloor material was removed during the eruption, most of which we conclude was redeposited within 20 km of the caldera by long run-out seafloor density currents. These powerful currents damaged seafloor cables over a length of >100 km, reshaped the seafloor, and caused mass-mortality of seafloor life. Biological (mega-epifaunal invertebrate) seafloor communities only survived the eruption where local topography provided a physical barrier to density currents (e.g., on nearby seamounts). While the longer-term consequences of such a large eruption for human, ecological and climatic systems are emerging, we expect that these previously-undocumented refugia will play a key role in longer-term ecosystem recovery.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses
Authors: Meade Nathan , Toreev Helen K. , Chakrabarty Ram P. , Hesser Charles R. , Park Chorong , Chandel Navdeep S. , Walsh Derek
Published: November 2023

Poxviruses are unusual DNA viruses that replicate in the cytoplasm. To do so, they encode approximately 100 immunomodulatory proteins that counteract cytosolic nucleic acid sensors such as cGAMP synthase (cGAS) along with several other antiviral response pathways. Yet most of these immunomodulators are expressed very early in infection while many are variable host range determinants, and significant gaps remain in our understanding of poxvirus sensing and evasion strategies. Here, we show that after infection is established, subsequent progression of the viral lifecycle is sensed through specific changes to mitochondria that coordinate distinct aspects of the antiviral response. Unlike other viruses that cause extensive mitochondrial damage, poxviruses sustain key mitochondrial functions including membrane potential and respiration while reducing reactive oxygen species that drive inflammation. However, poxvirus replication induces mitochondrial hyperfusion that independently controls the release of mitochondrial DNA (mtDNA) to prime nucleic acid sensors and enables an increase in glycolysis that is necessary to support interferon stimulated gene (ISG) production. To counter this, the poxvirus F17 protein localizes to mitochondria and dysregulates mTOR to simultaneously destabilize cGAS and block increases in glycolysis. Our findings reveal how the poxvirus F17 protein disarms specific mitochondrially orchestrated responses to later stages of poxvirus replication.
The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology
Authors: Wang Yu-Jun , Zan Gui-Ying , Xu Cenglin , Li Xue-Ping , Shu Xuelian , Yao Song-Yu , Xu Xiao-Shan , Qiu Xiaoyun , Chen Yexiang , Jin Kai , Zhou Qi-Xin , Ye Jia-Yu , Wang Yi , Xu Lin , Chen Zhong , Liu Jing-Gen
Published: November 2023

Ample evidence has suggested the stress etiology of depression, but the underlying mechanism is not fully understood yet. Here, we report that chronic social defeat stress (CSDS) attenuates the excitatory output of the claustrum (CLA) to the prelimbic cortex (PL) through the dynorphin/κ-opioid receptor (KOR) signaling, being critical for depression-related behaviors in male mice. The CSDS preferentially impairs the excitatory output from the CLA onto the parvalbumin (PV) of the PL, leading to PL micronetwork dysfunction by disinhibiting pyramidal neurons (PNs). Optogenetic activation or inhibition of this circuit suppresses or promotes depressive-like behaviors, which is reversed by chemogenetic inhibition or activation of the PV neurons. Notably, manipulating the dynorphin/KOR signaling in the CLA-PL projecting terminals controls depressive-like behaviors that is suppressed or promoted by optogenetic activation or inhibition of CLA-PL circuit. Thus, this study reveals both mechanism of the stress etiology of depression and possibly therapeutic interventions by targeting CLA-PL circuit.
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
Authors: Xue Gang , Xie Jianing , Hinterndorfer Matthias , Cigler Marko , Dötsch Lara , Imrichova Hana , Lampe Philipp , Cheng Xiufen , Adariani Soheila Rezaei , Winter Georg E. , Waldmann Herbert
Published: November 2023

Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-indolinones reported to bind the autophagy-related LC3B-protein and ligands of the PDEδ lipoprotein chaperone, the BRD2/3/4-bromodomain containing proteins and the BTK- and BLK kinases. Unexpectedly, the resulting bifunctional degraders do not induce protein degradation by means of macroautophagy, but instead direct their targets to the ubiquitin-proteasome system. Target and mechanism identification reveal that the arylidene-indolinones covalently bind DCAF11, a substrate receptor in the CUL4A/B-RBX1-DDB1-DCAF11 E3 ligase. The tempered α, β-unsaturated indolinone electrophiles define a drug-like DCAF11-ligand class that enables exploration of this E3 ligase in chemical biology and medicinal chemistry programs. The arylidene-indolinone scaffold frequently occurs in natural products which raises the question whether E3 ligand classes can be found more widely among natural products and related compounds.
Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy
Authors: Ning Caibo , Fan Linyun , Jin Meng , Wang Wenji , Hu Zhiqiang , Cai Yimin , Chen Liangkai , Lu Zequn , Zhang Ming , Chen Can , Li Yanmin , Zhang Fuwei , Wang Wenzhuo , Liu Yizhuo , Chen Shuoni , Jiang Yuan , He Chunyi , Wang Zhuo , Chen Xu , Li Hanting , Li Gaoyuan , Ma Qianying , Geng Hui , Tian Wen , Zhang Heng , Liu Bo , Xia Qing , Yang Xiaojun , Liu Zhongchun , Li Bin , Zhu Ying , Li Xiangpan , Zhang Shaoting , Tian Jianbo , Miao Xiaoping
Published: November 2023

Left ventricular regional wall thickness (LVRWT) is an independent predictor of morbidity and mortality in cardiovascular diseases (CVDs). To identify specific genetic influences on individual LVRWT, we established a novel deep learning algorithm to calculate 12 LVRWTs accurately in 42,194 individuals from the UK Biobank with cardiac magnetic resonance (CMR) imaging. Genome-wide association studies of CMR-derived 12 LVRWTs identified 72 significant genetic loci associated with at least one LVRWT phenotype (P < 5 × 10−8), which were revealed to actively participate in heart development and contraction pathways. Significant causal relationships were observed between the LVRWT traits and hypertrophic cardiomyopathy (HCM) using genetic correlation and Mendelian randomization analyses (P < 0.01). The polygenic risk score of inferoseptal LVRWT at end systole exhibited a notable association with incident HCM, facilitating the identification of high-risk individuals. The findings yield insights into the genetic determinants of LVRWT phenotypes and shed light on the biological basis for HCM etiology.
Reconstructing aerosol optical depth using spatiotemporal Long Short-Term Memory convolutional autoencoder
Authors: Liang Lu , Daniels Jacob , Biancardi Michael , Zhou Yuye
Published: November 2023

Aerosol Optical Depth (AOD) is a crucial atmospheric parameter in comprehending climate change, air quality, and its impacts on human health. Satellites offer exceptional spatiotemporal AOD data continuity. However, data quality is influenced by various atmospheric, landscape, and instrumental factors, resulting in data gaps. This study presents a new solution to this challenge by providing a long-term, gapless satellite-derived AOD dataset for Texas from 2010 to 2022, utilizing Moderate Resolution Imaging Spectroradiometer (MODIS) Multi-angle Implementation of Atmospheric Correction (MAIAC) products. Missing AOD data were reconstructed using a spatiotemporal Long Short-Term Memory (LSTM) convolutional autoencoder. Evaluation against an independent test dataset demonstrated the model’s effectiveness, with an average Root Mean Square Error (RMSE) of 0.017 and an R2 value of 0.941. Validation against the ground-based AERONET dataset indicated satisfactory agreement, with RMSE values ranging from 0.052 to 0.067. The reconstructed AOD data are available at daily, monthly, quarterly, and yearly scales, providing a valuable resource to advance understanding of the Earth’s atmosphere and support decision-making concerning air quality and public health.
Oxidative stress and docosahexaenoic acid injury lead to increased necroptosis and ferroptosis in retinal pigment epithelium
Authors: Neiteler Almar , Palakkan Anwar A. , Gallagher Kevin M. , Ross James A.
Published: November 2023

Age-related macular degeneration (AMD) is a complex disease caused by different genetic and environmental risk factors leading to loss of cells in the central part of the retina. Oxidative stress appears to be an important environmental risk factor that contributes to both the initiation and progression of AMD. Retinal pigment epithelium (RPE) plays an important role in regulating oxidative stress in the retina and is one of the main retinal cell types affected in AMD. A main function of RPE is to phagocytose photoreceptor outer segments (POS) which are rich in the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), making this cell type potentially more susceptible to oxidative stress-induced lipid peroxidation which can lead to cell death. RPE is known to undergo necrotic cell death in response to oxidative stress. The aim of this study was to determine if DHA in POS can increase oxidative damage to RPE. It was found that RPE undergo increased lipid peroxidation and decreased cell viability when stressed with hydrogen peroxide in combination with DHA or POS. H2O2-induced oxidative stress was found to cause both ferroptosis and necroptosis. However, the ferroptosis regulator acyl-CoA synthetase long-chain family member 4 (ACSL4) was found to be downregulated in RPE exposed to H2O2 and this effect was exacerbated when the RPE cells were simultaneously treated with DHA. Together, these results show a response of RPE when stressed which will likely be overwhelmed under disease conditions such as AMD resulting in cell death.
Enhancing robot evolution through Lamarckian principles
Authors: Luo Jie , Miras Karine , Tomczak Jakub , Eiben Agoston E.
Published: November 2023

Evolutionary robot systems offer two principal advantages: an advanced way of developing robots through evolutionary optimization and a special research platform to conduct what-if experiments regarding questions about evolution. Our study sits at the intersection of these. We investigate the question “What if the 18th-century biologist Lamarck was not completely wrong and individual traits learned during a lifetime could be passed on to offspring through inheritance?” We research this issue through simulations with an evolutionary robot framework where morphologies (bodies) and controllers (brains) of robots are evolvable and robots also can improve their controllers through learning during their lifetime. Within this framework, we compare a Lamarckian system, where learned bits of the brain are inheritable, with a Darwinian system, where they are not. Analyzing simulations based on these systems, we obtain new insights about Lamarckian evolution dynamics and the interaction between evolution and learning. Specifically, we show that Lamarckism amplifies the emergence of ‘morphological intelligence’, the ability of a given robot body to acquire a good brain by learning, and identify the source of this success: newborn robots have a higher fitness because their inherited brains match their bodies better than those in a Darwinian system.
Extraction-free LAMP assays for generic detection of Old World Orthopoxviruses and specific detection of Mpox virus
Authors: Li Zhiru , Sinha Amit , Zhang Yinhua , Tanner Nathan , Cheng Hui-Ting , Premsrirut Prem , Carlow Clotilde K. S.
Published: November 2023

Mpox is a neglected zoonotic disease endemic in West and Central Africa. The Mpox outbreak with more than 90,000 cases worldwide since 2022 generated great concern about future outbreaks and highlighted the need for a simple and rapid diagnostic test. The Mpox virus, MPV, is a member of the Orthopoxvirus (OPV) genus that also contains other pathogenic viruses including variola virus, vaccinia virus, camelpox virus, and cowpox virus. Phylogenomic analysis of 200 OPV genomes identified 10 distinct phylogroups with the New World OPVs placed on a very long branch distant from the Old World OPVs. Isolates derived from infected humans were found to be distributed across multiple phylogroups interspersed with isolates from animal sources, indicating the zoonotic potential of these viruses. In this study, we developed a simple and sensitive colorimetric LAMP assay for generic detection of Old World OPVs. We also developed an MPV-specific probe that differentiates MPV from other OPVs in the N1R LAMP assay. In addition, we described an extraction-free protocol for use directly with swab eluates in LAMP assays, thereby eliminating the time and resources needed to extract DNA from the sample. Our direct LAMP assays are well-suited for low-resource settings and provide a valuable tool for rapid and scalable diagnosis and surveillance of OPVs and MPV.
Enhancing supercapacitor performance through design optimization of laser-induced graphene and MWCNT coatings for flexible and portable energy storage
Authors: Tariq Hassan , Awan Saif Ullah , Hussain Danish , Rizwan Syed , Shah Saqlain A. , Zainab Sana , Riaz M. Bilal
Published: November 2023

The field of supercapacitors consistently focuses on research and challenges to improve energy efficiency, capacitance, flexibility, and stability. Low-cost laser-induced graphene (LIG) offers a promising alternative to commercially available graphene for next-generation wearable and portable devices, thanks to its remarkable specific surface area, excellent mechanical flexibility, and exceptional electrical properties. We report on the development of LIG-based flexible supercapacitors with optimized geometries, which demonstrate high capacitance and energy density while maintaining flexibility and stability. Three-dimensional porous graphene films were synthesized, and devices with optimized parameters were fabricated and tested. One type of device utilized LIG, while two other types were fabricated on LIG by coating multi-walled carbon nanotubes (MWCNT) at varying concentrations. Characterization techniques, including scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), Raman spectroscopy, and voltammetry, were employed to analyze the fabricated devices. AFM analysis revealed a surface roughness of 2.03 µm for LIG due to laser treatment. SEM images displayed compact, dense, and porous surface morphology. XRD analysis confirmed the presence of graphene and graphene oxide, which was further supported by energy-dispersive X-ray spectroscopy (EDX) data. Raman spectroscopy indicated that the fabricated samples exhibited distinct D and G bands at 1362 cm–1and 1579 cm–1, respectively. Cyclic voltammetry (CV) results showed that LIG's capacitance, power density, and energy density were 6.09 mF cm–2, 0.199 mW cm–2, and 3.38 µWh cm–2, respectively, at a current density of 0.2 mA cm–2. The LIG-MWCNT coated electrode exhibited a higher energy density of 6.05 µWh cm–2and an areal-specific capacitance of 51.975 mF cm–2compared to the LIG-based devices. The fabricated device has potential applications in smart electronics, nanorobotics, microelectromechanical systems (MEMS), and wearable and portable electronics.
A concave four-arc honeycomb with enhanced stiffness and desirable negative Poisson’s effect
Authors: Feng Ning , Tie Yuanhao , Guo Ronghui , Yuan Qingwen , Xue Fengling , Li Cheng , Lv Liwen , Xie Weibo
Published: November 2023

The conventional star-shaped honeycomb (CSSH) structure is inherently rich in mechanical properties. Based on the CSSH structure, the Poisson's ratio and Young’s modulus can be improved by adding the tip re-entrant angle (ISSH). In this paper, a new concave four-arc honeycomb (CFAH) structure is proposed by designing the straight rod as a curved rod and retaining the tip re-entrant angle from the ISSH structure. The Young's modulus, specific stiffness and Poisson’s ratio of CFAH structures are derived from Castigliano’s second theorem and Moore’s theorem. The theoretical results show good agreement with the numerical and experimental results. The results show that the normalized effective specific stiffness and normalized effective Young’s modulus of the CFAH structure are further improved by about 12.95% and 16.86%, respectively, compared with the ISSH structure, and more significant auxiliary effects are obtained. CFAH structures show good promise in aerospace, construction and other applications due to their enhanced mechanical property. Meanwhile, the present work provides guidance for the study of concave four-arc honeycomb structures.
A longitudinal study of the association of epidural anesthesia and low-dose synthetic oxytocin regimens with breast milk supply and breastfeeding rates
Authors: Takahata Kaori , Horiuchi Shigeko , Miyauchi Ai , Tadokoro Yuriko , Shuo Takuya
Published: November 2023

Breastfeeding is known to improve maternal and child health. However, epidural anesthesia (EDA) and synthetic oxytocin (synOT) are suggested to have negative effects on breastfeeding. In this study, we aimed to determine the effects of intrapartum synOT and EDA on breast milk supply, breastfeeding rates, and maternal salivary oxytocin levels. Women were recruited during pregnancy or after birth at a single hospital. Data were collected at 3 days postpartum (T1), 1 month postpartum (T2), and 4 months postpartum (T3) on 83 low-risk primiparous women who planned to breastfeed for at least 12 weeks postpartum to avoid dropouts from early discontinuance of breastfeeding. Women with cesarean section, twin pregnancy, premature neonates, and an Apgar score of < 7 at 5 min were excluded. Participants recorded their 24-h milk supply by test weights at 3 days and 1 month postpartum. Additionally, they filled out questionnaires assessing their breastfeeding level and lactogenesis stage II initiation. Salivary oxytocin levels were obtained at 3 days postpartum. Women who delivered using EDA had lower salivary oxytocin levels (P = .055, d = .442), breast milk supply in early postpartum (P = .025, d = .520) and at 1 month postpartum (P = .036, d = .483), and breastfeeding rates at 4 months postpartum (P = .037, V = .236) than women who did not deliver using EDA. There was no association between breastfeeding and the use of intrapartum synOT. In conclusion, this study showed that women who delivered using EDA had lower breast milk supply in the early postpartum period and breastfeeding rates at 4 months postpartum. It also revealed that using synOT at low doses during labor did not affect breastfeeding. Thus, women who deliver using EDA need support for increased breast milk supply in the early postpartum period.

Trial registration: UMIN000037783 (Clinical Trials Registry of University Hospital Information Network).
Research on the stipe cracking of wine-cap mushroom (Stropharia rugosoannulata) in different humidity conditions
Authors: Huang Lei , Si Can , Shi Hongyu , He Chunmei , Duan Jun
Published: November 2023

Stropharia rugosoannulata is a well-renowned edible mushroom due to its nutritional and nutraceutical properties. This article focuses on the study of stipe cracking in S. rugosoannulata, a common issue in outdoor cultivation of this mushroom in South China. The findings reveal that the stipe cracks of S. rugosoannulata are primarily horizontal (transverse). Typically, cracks appear between the annulus and the middle part of the stipe prior to the opening of the pileus. Following the opening of the pileus, a fresh crack appears on the upper part of the stipe above the annulus. During the growth of S. rugosoannulata, two distinct elongation sections are observed in the stipe, separated by the annulus. The location of cracks coincides with these elongation sections, and the sequence of crack occurrences matches with the sequence of these elongation sections. The frequency of stipe cracking varies according to developmental stages and humidity conditions. The conclusion of this study is that S. rugosoannulata stipes crack during elongation and within elongation sections when humidity is low (≤ 60%), with the S3 developmental stage having the highest risk of cracking.
Posttraumatic arthritis and functional outcomes of nonoperatively treated distal radius fractures after 3 years
Authors: Thorninger Rikke , Romme Karen Larsen , Wæver Daniel , Henriksen Martin Bille , Tjørnild Michael , Lind Martin , Rölfing Jan Duedal
Published: November 2023

Recent studies have shown that distal radius fractures (DRFs) in elderly patients can be treated nonoperatively with good functional results after 1 year. However, scientific evidence regarding longer follow-up to assess posttraumatic arthritis (PA), complications, and functional outcomes is scarce. This prospective case series aimed to evaluate these outcomes in a cohort of patients ≥ 65-year-old with nonoperatively treated DRFs after a minimum of 3 years. The primary outcome was PA. Secondary outcomes were complications, Quick Disabilities of the Arm, Shoulder and Hand Outcome Measure (QuickDASH), Patient-Rated Wrist/Hand Evaluation (PRWHE), pain, range of motion and grip strength. The full data of 32 patients with a mean follow-up of 3.3 years were available: 10/32 patients had radiological signs of PA, but only 2 of these patients reported pain. A total of 11/32 fractures healed in malunion (> 10° dorsal angulation). There was no significant difference in QuickDASH or PRWHE from 1 year to the latest follow-up after more than 3 years. This study thus adds to the literature stating that radiological signs, including PA and malunion, do not necessarily result in symptoms. Moreover, it underpins that nonoperative treatment of these patients results in good functional outcomes after 1 and 3 years.
Behavioral examination of the role of the primary visual cortex in the perceived size representation
Authors: Yoo Sang-Ah , Joo Sung Jun
Published: November 2023

Previous research has shown that neural activity in the primary visual cortex (V1) and V1 surface area may be linked with subjective experience of size illusions. Here, we behaviorally measured the hallway illusion with experimental manipulations as a proxy of V1’s influence on size perception. We first tested whether the hallway illusion can persist without further recurrent processing by using backward masking. Next, we examined relations among the hallway illusion magnitude and other perceptual measures that have been suggested to be correlated with V1 surface area. In Experiment 1, the magnitude of the hallway illusion was not affected by the stimulus duration and visual masking when the hallway context was previewed (i.e., complex depth information is already processed). It suggests that V1 activity could support the size illusion to some extent even when recurrent processing between V1 and higher areas is disturbed. In Experiment 2, the hallway illusion magnitude was correlated with the Vernier acuity threshold, but not with physical size discriminability. Our results provide converging evidence with the previous findings in that neural activity in V1 may contribute to size illusions and that V1 surface area is not the sole factor that mediates size perception and visual precision.
Reconstructing growth and dynamic trajectories from single-cell transcriptomics data
Authors: Sha Yutong , Qiu Yuchi , Zhou Peijie , Nie Qing
Published: November 2023

Time-series single-cell RNA sequencing (scRNA-seq) datasets provide unprecedented opportunities to learn dynamic processes of cellular systems. Due to the destructive nature of sequencing, it remains challenging to link the scRNA-seq snapshots sampled at different time points. Here we present TIGON, a dynamic, unbalanced optimal transport algorithm that reconstructs dynamic trajectories and population growth simultaneously as well as the underlying gene regulatory network from multiple snapshots. To tackle the high-dimensional optimal transport problem, we introduce a deep learning method using a dimensionless formulation based on the Wasserstein–Fisher–Rao (WFR) distance. TIGON is evaluated on simulated data and compared with existing methods for its robustness and accuracy in predicting cell state transition and cell population growth. Using three scRNA-seq datasets, we show the importance of growth in the temporal inference, TIGON’s capability in reconstructing gene expression at unmeasured time points and its applications to temporal gene regulatory networks and cell–cell communication inference.
The determination of underivatized chlormequat, fosetyl-aluminium and phosphonic acid residues in maize and soybean by LC-MS/MS
Authors: Yang Hao , Geng Yue , Lin Shu , Wang Lu , Peng Yi , Xu Yaping , Zhang Jingran , Liu Xiaowei
Published: November 2023

A simple, rapid and sensitive method was developed for the simultaneous determination of underivatized chlormequat, fosetyl-aluminium and phosphonic acid residues in maize and soybean using liquid chromatography-triple quadrupole mass spectrometry.
Fourteen-membered macrocyclic cobalt complex for the electrolysis of low-concentration gaseous carbon dioxide with high faradaic efficiency toward carbon monoxide
Authors: Inada Takeshi , Iguchi Shoji , Yamamoto Masahiro , Hasegawa Yusuke , Moriya Makoto , Ohyama Junya , Nabae Yuta , Naniwa Shimpei , Tanaka Tsunehiro , Teramura Kentaro
Published: November 2023

Fourteen-membered macrocyclic cobalt complex exhibit superior activity in the electrolysis for the reduction of CO2, achieving a high current density, high Faradic efficiency, low overpotential, and high durability. Faradic efficiency of CO under 10% CO2 atmosphere was above 95%.
Porous carbons prepared from a novel hard wood composite waste for effective adsorption of Pb(ii) and Cd(ii) ions
Authors: El-Wakeel Shaimaa T. , Fathy Nady A. , Tawfik Magda E.
Published: November 2023

SEM figures describe conversion of a hard wood composite waste to porous carbons enclosed with graphene sheets.
Green approach for the fabrication of a ternary nanocatalyst (Ag-ZnONPs@Cy) for visible light-induced photocatalytic reduction of nitroarenes to aminoarenes
Authors: Kader Dana A.
Published: November 2023

In recent times, the incorporation of metal oxide nanoparticles with organic dyes has piqued the interest of numerous researchers due to their diverse applications under visible light instead of UV radiation.
Boosting the interfacial dynamics and thermodynamics in polyanion cathode by carbon dots for ultrafast-charging sodium ion batteries
Authors: Li Yujin , Mei Yu , Momen Roya , Song Bai , Huang Yujie , Zhong Xue , Ding Hanrui , Deng Wentao , Zou Guoqiang , Hou Hongshuai , Ji Xiaobo
Published: November 2023

An interfacial dynamics and thermodynamics synergistic strategy is proposed to synchronously enhance the fast-charging capability of polyanion cathode materials for SIBs, and the designed NVP/NSC cathode exhibits excellent performance at 100C.
Highly dispersed Pd-based pseudo-single atoms in zeolites for hydrogen generation and pollutant disposal
Authors: Zhang Kai , Wang Ning , Meng Yali , Zhang Tianjun , Zhao Pu , Sun Qiming , Yu Jihong
Published: November 2023

Pd-based pseudo-single atoms are confined within zeolites via an energy-efficient ligand-protected direct H2 reduction method, and exhibit excellent catalytic activity and stability in hydrogen storage and pollutant disposal reactions.
Charge transfer enhancement at the CZTS photocathode interface using ITO for efficient solar water reduction
Authors: Tay Ying Fan , Zhang Mengyuan , Zhang Shuo , Lie Stener , Chiam Sing Yang , Wong Lydia Helena
Published: November 2023

The study employs an ITO layer to enhance CZTS photocathodes for water splitting, resulting in improved photocurrent, onset potential, and stability through phosphate ion removal and In–Pt/Sn–Pt interactions on the ITO surface.