bluuebunny/crossref_metadata_2025 huggingface dataset:
Causal representation of multi-loop Feynman integrands within the loop-tree duality
Authors: Aguilera-Verdugo J. Jesús , Hernández-Pinto Roger J. , Rodrigo Germán , Sborlini German F. R. , Torres Bobadilla William J.
Published: January 2021

Abstract

The numerical evaluation of multi-loop scattering amplitudes in the Feynman representation usually requires to deal with both physical (causal) and unphysical (non-causal) singularities. The loop-tree duality (LTD) offers a powerful framework to easily characterise and distinguish these two types of singularities, and then simplify analytically the underling expressions. In this paper, we work explicitly on the dual representation of multi-loop Feynman integrals generated from three parent topologies, which we refer to as Maximal, Next-to-Maximal and Next-to-Next-to-Maximal loop topologies. In particular, we aim at expressing these dual contributions, independently of the number of loops and internal configurations, in terms of causal propagators only. Thus, providing very compact and causal integrand representations to all orders. In order to do so, we reconstruct their analytic expressions from numerical evaluation over finite fields. This procedure implicitly cancels out all unphysical singularities. We also interpret the result in terms of entangled causal thresholds. In view of the simple structure of the dual expressions, we integrate them numerically up to four loops in integer space-time dimensions, taking advantage of their smooth behaviour at integrand level.
Wilson-’t Hooft lines as transfer matrices
Authors: Maruyoshi Kazunobu , Ota Toshihiro , Yagi Junya
Published: January 2021

Abstract

We establish a correspondence between a class of Wilson-’t Hooft lines in four-dimensional$$ \mathcal{N} $$N= 2 supersymmetric gauge theories described by circular quivers and transfer matrices constructed from dynamical L-operators for trigonometric quantum integrable systems. We compute the vacuum expectation values of the Wilson-’t Hooft lines in a twisted product spaceS1×ϵℝ2× ℝ by supersymmetric localization and show that they are equal to the Wigner transforms of the transfer matrices. A variant of the AGT correspondence implies an identification of the transfer matrices with Verlinde operators in Toda theory, which we also verify. We explain how these field theory setups are related to four-dimensional Chern-Simons theory via embedding into string theory and dualities.
BMS symmetry via AdS/CFT
Authors: Lowe David A. , Ramirez David M.
Published: January 2021

Abstract

With a view to understanding extended-BMS symmetries in the framework of the AdS4/CFT3 correspondence, asymptotically AdS geometries are constructed with null impulsive shockwaves involving a discontinuity in superrotation parameters. The holographic dual is proposed to be a two-dimensional Euclidean defect conformal field localized on a particular timeslice in a three-dimensional conformal field theory on de Sitter spacetime. The defect conformal field theory generates a natural action of the Virasoro algebra. The large radius of curvature limit ℓ → ∞ yields spacetimes with nontrivial extended-BMS charges corresponding to a single set of Virasoro charges.
Socio-demographic factors associated with self-protecting behavior during the Covid-19 pandemic
Authors: Papageorge Nicholas W. , Zahn Matthew V. , Belot Michèle , van den Broek-Altenburg Eline , Choi Syngjoo , Jamison Julian C. , Tripodi Egon
Published: January 2021

Given the role of human behavior in the spread of disease, it is vital to understand what drives people to engage in or refrain from health-related behaviors during a pandemic. This paper examines factors associated with the adoption of self-protective health behaviors, such as social distancing and mask wearing, at the start of the Covid-19 pandemic in the USA. These behaviors not only reduce an individual’s own risk of infection but also limit the spread of disease to others. Despite these dual benefits, universal adoption of these behaviors is not assured. We focus on the role of socioeconomic differences in explaining behavior, relying on data collected in April 2020 during the early stages of the Covid-19 pandemic. The data include information on income, gender and race along with unique variables relevant to the current pandemic, such as work arrangements and housing quality. We find that higher income is associated with larger changes in self-protective behaviors. These gradients are partially explained by the fact that people with less income are more likely to report circumstances that make adopting self-protective behaviors more difficult, such as an inability to tele-work. Both in the USA and elsewhere, policies that assume universal compliance with self-protective measures—or that otherwise do not account for socioeconomic differences in the costs of doing so—are unlikely to be effective or sustainable.
A teaching tool about the fickle p value and other statistical principles based on real-life data
Authors: Alawbathani Salem , Batool Mehreen , Fleckhaus Jan , Hamad Sarkawt , Hassenrück Floyd , Hou Yanhong , Li Xia , Salmanton-García Jon , Ullah Sami , Wieters Frederique , Michel Martin C.
Published: January 2021

A poor understanding of statistical analysis has been proposed as a key reason for lack of replicability of many studies in experimental biomedicine. While several authors have demonstrated the fickleness of calculated p values based on simulations, we have experienced that such simulations are difficult to understand for many biomedical scientists and often do not lead to a sound understanding of the role of variability between random samples in statistical analysis. Therefore, we as trainees and trainers in a course of statistics for biomedical scientists have used real data from a large published study to develop a tool that allows scientists to directly experience the fickleness of p values. A tool based on a commonly used software package was developed that allows using random samples from real data. The tool is described and together with the underlying database is made available. The tool has been tested successfully in multiple other groups of biomedical scientists. It can also let trainees experience the impact of randomness, sample sizes and choice of specific statistical test on measured p values. We propose that live exercises based on real data will be more impactful in the training of biomedical scientists on statistical concepts.
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
Authors: Lea Dordi , Watson Martin , Skaland Ivar , Hagland Hanne R. , Lillesand Melinda , Gudlaugsson Einar , Søreide Kjetil
Published: January 2021

Background

In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, the incurred expenses and copyrights may prevent universal use. The aim of this study was to develop a robust and objective quantification method of TILs in colon cancer.

Methods

A consecutive, unselected series of specimens from patients with colon cancer were available for immunohistochemistry and assessment of TILs by automated digital pathology. CD3 + and CD8 + cells at the invasive margin and in tumor center were assessed on consecutive sections using automated digital pathology and image analysis software (Visiopharm®). An algorithm template for whole slide assessment, generated cell counts per square millimeters (cells/mm2), from which the immune score was calculated using distribution volumes. Furthermore, immune score was compared with clinical and histopathological characteristics to confirm its relevance.

Results

Based on the quantified TILs numbers by digital image analyses, patients were classified into low (n = 83, 69.7%), intermediate (n = 14, 11.8%) and high (n = 22, 18.5%) immune score groups. High immune score was associated with stage I–II tumors (p = 0.017) and a higher prevalence of microsatellite instable (MSI) tumors (p = 0.030). MSI tumors had a significantly higher numbers of CD3 + TILs in the invasive margin and CD8 + TILs in both tumor center and invasive margin, compared to microsatellite stable (MSS) tumors.

Conclusion

A digital template to quantify an easy-to-use immune score corresponds with clinicopathological features and MSI in colon cancer.
Robot-Assisted Carotid Artery Stenting: A Safety and Feasibility Study
Authors: Jones Ben , Riga Celia , Bicknell Colin , Hamady Mohamad
Published: January 2021

Purpose

Endovascular robotics is an emerging technology within the developing field of medical robotics. This was a prospective evaluation to assess safety and feasibility of robotic-assisted carotid artery stenting.

Materials and Methods

Consecutive cases of carotid artery stenting cases performed over period of 24 months, from May 2015 to October 2016, using the Magellan Robotic System (Hansen, Mountain View, CA) were included. All cases utilised the robotic system to navigate the arch, obtain a stable position in the common carotid artery, followed by manual manipulation of Embolic Protection Devices and self-expandable stents through the robotic catheter. Patients demographics, clinical indications, anatomical features, technical and clinical success, complication rate and hospital stay were prospectively recorded.

Results

Thirteen patients, 10 males (78.5%), with an average age of 68.7 years were treated. Mean follow up time was 30 months. Ten patients (91%) were symptomatic at presentation. Anatomical indications for endovascular stent insertion were previous open surgery to the neck ± radiotherapy (87.5%) and hostile anatomy for open surgery (12.5%). Technical success was 100% and the robotic system demonstrates enhanced stability during arch and lesion crossing. There were no neurological complications post-operatively. Average hospital stay was 3 days (range 2–6 days) and a change in serum creatinine of −7.8 μmol/L. There was no documented case of in stent restenosis, new or worsening neurology during follow-up.

Conclusion

These results illustrate safety and feasibility of robotic endovascular revascularisation for carotid disease and demonstrates potential to enhance peri-procedural safety through improved control and stability.
Volumetric assessment of the periablational safety margin after thermal ablation of colorectal liver metastases
Authors: Laimer Gregor , Jaschke Nikolai , Schullian Peter , Putzer Daniel , Eberle Gernot , Solbiati Marco , Solbiati Luigi , Goldberg S. Nahum , Bale Reto
Published: January 2021

Objectives

To retrospectively assess the periablational 3D safety margin in patients with colorectal liver metastases (CRLM) referred for stereotactic radiofrequency ablation (RFA) and to evaluate its influence on local treatment success.

Methods

Forty-five patients (31 males; mean age 64.5 [range 31–87 years]) with 76 CRLM were treated with stereotactic RFA and retrospectively analyzed. Image fusion of pre- and post-interventional contrast-enhanced CT scans using a non-rigid registration software enabled a retrospective assessment of the percentage of predetermined periablational 3D safety margin and CRLM successfully ablated. Periablational safety zones (1–10 mm) and percentage of periablational zone ablated were calculated, analyzed, and compared with subsequent tumor growth to determine an optimal safety margin predictive of local treatment success.

Results

Mean overall follow-up was 36.1 ± 18.5 months. Nine of 76 CRLMs (11.8%) developed local tumor progression (LTP) with mean time to LTP of 18.3 ± 11.9 months. Overall 1-, 2-, and 3-year cumulative LTP-free survival rates were 98.7%, 90.6%, and 88.6%, respectively. The periablational safety margin assessment proved to be the only independent predictor (p < 0.001) of LTP for all calculated safety margins. The smallest safety margin 100% ablated displaying no LTP was 3 mm, and at least 90% of a 6-mm circumscribed 3D safety margin was required to achieve complete ablation.

Conclusions

Volumetric assessment of the periablational safety margin can be used as an intraprocedural tool to evaluate local treatment success in patients with CRLM referred to stereotactic RFA. Ablations achieving 100% 3D safety margin of 3 mm and at least 90% 3D safety margin of 6 mm can predict treatment success.

Key Points

• Volumetric assessment of the periablational safety margin can be used as an intraprocedural tool to evaluate local treatment success following thermal ablation of colorectal liver metastases.

• Ablations with 100% 3D periablational safety margin of 3 mm and ablations with at least 90% 3D safety margin of 6 mm can be considered indications of treatment success.

• Image fusion of pre- and post-interventional CT scans with the software used in this study is feasible and could represent a useful tool in daily clinical practice.
Manual therapy of infants with postural and movement asymmetries and positional preference
Authors: Sacher Robby , Knüdeler Martin , Wuttke Marc , Wüstkamp Nadine , Derlien Steffen , Loudovici-Krug Dana
Published: January 2021

Background

There are different therapeutic approaches to persistent positional preference (kinematic imbalance due to suboccipital strain, KISS) in infants. There are no evidence-based or controlled studies investigating the effect of manual medicine treatment in children aged 3–6 months, particularly in combination with a home exercise programme. The presented monocentric study on one-time manual medicine treatment of infants aged 14–24 exhibiting these symptoms aims to close this gap.

Methods

This study comprises a controlled double-blind trial and per-protocol-analysis. Primary outcome was the 4-item symmetry score (4–17 points). The second measurement was performed after 4–6 weeks.

Results

A total of 62 infants were treated and evaluated (mean age 17 weeks). The intervention and control groups started with a symmetry score of 12.9 ± 2.1 and 12.5 ± 1.7 points, respectively. In the intervention group the score improved by 4.9 ± 2.4 to 8.0 ± 2.7 points, in the control group it improved by 2.9 ± 2.9 to 9.6 ± 3.0 points. The difference between the groups was statistically significant (p = 0.03). Both groups had significantly better values over time (p < 0.001). No adverse events or side effects were observed.

Conclusion

Manual medicine treatment of infants with postural and movement asymmetries as well as positional preference in combination with a home exercise programme is superior to a home exercise programme alone. Both treatment concepts achieved significant improvements. However, the manual medicine treatment played an important role in reducing the symmetry score value for the affected children, such they were no longer in need of treatment.
Winter Arctic Amplification at the synoptic timescale, 1979–2018, its regional variation and response to tropical and extratropical variability
Authors: Hall Richard J. , Hanna Edward , Chen Linling
Published: January 2021

We investigate winter Arctic Amplification (AA) on synoptic timescales and at regional scales using a daily version of the Arctic Amplification Index (AAI) and examine causes on a synoptic scale. The persistence, frequency and intensity of high AAI events show significant increases over the Arctic. Similarly, low AAI events are decreasing in frequency, persistence and intensity. In both cases, there are regional variations in these trends, in terms of significance and timing. Significant trends in increasing persistence, frequency and intensity of high AAI events in winter are concentrated in the period 2000–2009, with few significant trends before and after this. There are some decreases in sea-ice concentration in response to synoptic-scale AA events and these AA events can contribute to the decadal trends in AA found in other studies. A sectoral analysis of the Arctic indicates that in the Beaufort–Chukchi and East Siberian–Laptev Seas, synoptic scale high AAI events can be driven by tropical teleconnections while in other Arctic sectors, it is the intrusion of moisture-transporting synoptic cyclones into the Arctic that is most important in synoptic-scale AA. The presence of Rossby wave breaking during high AAI events is indicative of forcing from lower latitudes, modulated by variations in the jet stream. An important conclusion is that the increased persistence, frequency and intensity of synoptic-scale high AAI events make significant contributions to the interannual trend in AA.
Death in the sauna-vitality markers for heat exposure
Authors: Wegner Anja , Doberentz Elke , Madea Burkhard
Published: January 2021

In sauna-associated deaths, the vitality of heat exposure is of great importance. Two case reports address this. First, we present the case of a 77-year-old man who was found dead in the sauna of his family home. When found, the sauna door was closed, and the sauna indicated a temperature of 78 °C. The body had already begun to decay and was partially mummified when it was found. In the other case, a 73-year-old woman was found dead in the sauna by her husband. In this case, the sauna door was also closed. The sauna was still in operation at a temperature of approximately 70 °C. Epidermal detachments were found. In both autopsies and their follow-up examinations, there were no indications of a cause of death competing with heat shock. The expression of heat shock proteins in kidneys and lungs and the expression of aquaporin 3 in skin were investigated to detect pre-mortal temperature influences.
Subjective and objective demands on different types of differential stress inventory
Authors: Karlsen Håvard R. , Böckelmann Irina , Thielmann Beatrice
Published: January 2021

Purpose

To validate the differential stress inventory (DSI) by evaluating the objective and subjective stress differences in the five DSI types in the occupational setting.

Methods

A total of 119 German participants working as medical assistants (n = 40) or in a bank (n = 79) were recruited. They completed the Maslach Burnout Inventory–General Survey, the DSI, and wore ECG measuring devices for 24 h to measure heart rate variability. The DSI was used to group people into one of five types according to how they perceived and coped with stress: normal, overstressed, stress-resistant, low stress/high coping, or high stress/high coping.

Results

The overstressed type had significantly more burnout symptoms than the other types. The high stress/high coping type also had more symptoms of emotional exhaustion and total burnout compared to the other types, while the low stress/high coping and the stress-resistant types generally had the lowest levels of burnout. There were no differences on the HRV parameters among the DSI types.

Conclusion

Categorising people into types like in the DSI can help make workers aware of unhealthy stress and coping patterns before they turn into more severe pathology. Proper application and targeted preventive measures can save the individual’s health and the company’s budget. While the DSI picked up on differences in burnout symptoms as a long-term consequence of stress, there is evidence that it cannot pick up on short-term stress or physical stress as measured by HRV from the 24 h recording.
The development of mature gait patterns in children during walking and running
Authors: Bach Margit M. , Daffertshofer Andreas , Dominici Nadia
Published: January 2021

Purpose

We sought to identify the developing maturity of walking and running in young children. We assessed gait patterns for the presence of flight and double support phases complemented by mechanical energetics. The corresponding classification outcomes were contrasted via a shotgun approach involving several potentially informative gait characteristics. A subsequent clustering turned out very effective to classify the degree of gait maturity.

Methods

Participants (22 typically developing children aged 2–9 years and 7 young, healthy adults) walked/ran on a treadmill at comfortable speeds. We determined double support and flight phases and the relationship between potential and kinetic energy oscillations of the center-of-mass. Based on the literature, we further incorporated a total of 93 gait characteristics (including the above-mentioned ones) and employed multivariate statistics comprising principal component analysis for data compression and hierarchical clustering for classification.

Results

While the ability to run including a flight phase increased with age, the flight phase did not reach 20% of the gait cycle. It seems that children use a walk-run-strategy when learning to run. Yet, the correlation strength between potential and kinetic energies saturated and so did the amount of recovered mechanical energy. Clustering the set of gait characteristics allowed for classifying gait in more detail. This defines a metric for maturity in terms of deviations from adult gait, which disagrees with chronological age.

Conclusions

The degree of gait maturity estimated statistically using various gait characteristics does not always relate directly to the chronological age of the child.
Olfactory coding in honeybees
Authors: Paoli Marco , Galizia Giovanni C.
Published: January 2021

With less than a million neurons, the western honeybee Apis mellifera is capable of complex olfactory behaviors and provides an ideal model for investigating the neurophysiology of the olfactory circuit and the basis of olfactory perception and learning. Here, we review the most fundamental aspects of honeybee’s olfaction: first, we discuss which odorants dominate its environment, and how bees use them to communicate and regulate colony homeostasis; then, we describe the neuroanatomy and the neurophysiology of the olfactory circuit; finally, we explore the cellular and molecular mechanisms leading to olfactory memory formation. The vastity of histological, neurophysiological, and behavioral data collected during the last century, together with new technological advancements, including genetic tools, confirm the honeybee as an attractive research model for understanding olfactory coding and learning.
Excavation and Conveying Technologies for Space Applications
Authors: Höber Dominik , Taschner Andreas , Fimbinger Eric
Published: January 2021

A rising number of companies and organisations are researching space technologies supporting extraterrestrial life. Whether Moon or Mars, the number of rocket launches is increasing year by year. The majority of National Space Agencies are planning exploration missions with fully autonomous robots, which can conduct several studies about the composition of the lunar dust. Especially the extraction of oxygen from the moon dust, called regolith, is of great interest. Also many other projects are planned. But the initial step of all processes is often forgotten: it is the supply of raw materials. Therefore, a closer look at the possibilities of excavating and conveying regolith has been taken. The research ranges from concept development, calculation to simulation and designing a robotic system.
CancerSupportSource®-15+: development and evaluation of a short form of a distress screening program for cancer patients and survivors
Authors: Zaleta Alexandra K. , McManus Shauna , Fortune Erica E. , DeRosa Branlyn W. , Buzaglo Joanne S. , Olson Julie S. , Goldberger Sara , Miller Melissa F.
Published: January 2021

Purpose

CancerSupportSource® (CSS) is a distress screening program implemented at community-based organizations and hospitals nationwide. The 25-item CSS assesses distress across five domains, with capacity to screen for clinically significant depression and anxiety. This study examined psychometric properties of a shortened form to enhance screening opportunities when staff or patient burden considerations are significant.

Methods

Development and validation were completed in multiple phases. Item reduction decisions were made with 1436 cancer patients by assessing external/internal item quality and judging theoretical and practical implications of items. Pearson correlations and confirmatory factor analysis were conducted on a separate sample of 957 patients to corroborate psychometric properties and dimensionality of the shortened scale. Nonparametric receiver operating characteristic (ROC) curve analyses determined scoring thresholds for depression and anxiety risk scales.

Results

Scale refinement resulted in a 15-item short form plus one screening item assessing tobacco and substance use (CSS-15+). At least two items from each CSS domain were retained to preserve multidimensionality. In confirmatory analysis, the model explained 59% of the variance and demonstrated good fit. Correlation between CSS-15+ and 25-item CSS was 0.99, p < 0.001. Sensitivity of 2-item depression and 2-item anxiety risk scales in the confirmatory sample were 0.82 and 0.83, respectively.

Conclusions

CSS-15+ is a brief, reliable, and valid multidimensional measure of distress. The measure retained excellent internal consistency (α = 0.94) and a stable factor structure. CSS-15+ is a practical and efficient screening tool for distress and risk for depression and anxiety among cancer patients and survivors, particularly in community-based settings.
Cardiovascular fingolimod effects on rapid baroreceptor unloading are counterbalanced by baroreflex resetting
Authors: Hilz Max J. , Roy Sankanika , de Rojas Leal Carmen , Liu Mao , Canavese Francesca , Winder Klemens , Hoesl Katharina M. , Lee De-Hyung , Linker Ralf A. , Wang Ruihao
Published: January 2021

Background and purpose

Initial cardiovascular fingolimod effects might compromise baroreflex responses to rapid blood pressure (BP) changes during common Valsalva-like maneuvers. This study evaluated cardiovascular responses to Valsalva maneuver (VM)-induced baroreceptor unloading and loading upon fingolimod initiation.

Patients and methods

Twenty-one patients with relapsing-remitting multiple sclerosis performed VMs before and 0.5, 1, 2, 3, 4, 5, and 6 hours after fingolimod initiation. We recorded heart rate (HR) as RR intervals (RRI), systolic and diastolic BP (BPsys, BPdia) during VM phase 1, VM phase 2 early, VM phase 2 late, and VM phase 4. Using linear regression analysis between decreasing BPsys and RRI values during VM phase 2 early, we determined baroreflex gain (BRG) reflecting vagal withdrawal and sympathetic activation upon baroreceptor unloading. To assess cardiovagal activation upon baroreceptor loading, we calculated Valsalva ratios (VR) between maximal and minimal RRIs after strain release. Analysis of variance or Friedman tests with post hoc analysis compared corresponding parameters at the eight time points (significance:p < 0.05).

Results

RRIs at VM phase 1, VM phase 2 early, and VM phase 2 late were higher after than before fingolimod initiation, and maximal after 4 hours. Fingolimod did not affect the longest RRIs upon strain release, but after 3, 5, and 6 hours lowered the highest BPsys values during overshoot and all BPdia values, and thus reduced VRs. BRG was slightly higher after 3 and 5 hours, and significantly higher after 4 hours than before fingolimod initiation.

Conclusions

VR-decreases 3–6 hours after fingolimod initiation are physiologic results of fingolimod-associated attenuations of BP and HR increases at the end of strain and do not suggest impaired cardiovagal activation upon baroreceptor loading. Stable and at the time of HR nadir significantly increased BRGs indicate improved responses to baroreceptor unloading. Thus, cardiovascular fingolimod effects do not impair autonomic responses to sudden baroreceptor loading or unloading but seem to be mitigated by baroreflex resetting.
A scoping review of the nature of physiotherapists’ role to avoid fall in people with Parkinsonism
Authors: Alatawi Salem F.
Published: January 2021

Background

Parkinson’s disease (PD) is considered a neurological disease with a high prevalence rate among population. One of its main problems is recurrent fall which has numerous contributing factors such as history of fall, fear of falling, gait deficits, impaired balance, poor functional mobility, and muscle weakness.

Objective

To review and explore the focus/nature of interventions which target the role of physiotherapy preventing fall in patients with PD.

Method

A scoping review was led dependent on Arksey and O’Malley as discussed by Wood et al. (2002). This paper based on this structure to perceive intervention studies have been embraced in physiotherapy to prevent fall after Parkinson’s disease. The search included various databases. The referencing arrangements of every pertinent paper were additionally filtered for more studies.

Findings

A total of 173 articles were included, 39 of which met the eligibility criteria. Fifteen studies reported on the direct impact of physiotherapy on fall, while the rest examined the impacts of physiotherapy on factors that are associated with fall. Different outcomes, interventions types, and duration were used in these studies. Findings showed a favorable result of physiotherapy on fall and near fall incidence, balance, gait, functional mobility, muscle strength, and fear of falling.

Conclusion

Physiotherapy has the possibility to decrease fall incidence and fall risk in people with PD. However, the heterogeneity in the patients’ selection, intervention studies, outcome measures chosen, time since the onset of disease, variation in intensity, and duration of treatment between included studies make the comparisons difficult. Consequently, more studies are needed on best intervention.
The impact of lockdown during SARS-CoV-2 outbreak on behavioral and psychological symptoms of dementia
Authors: Manini Arianna , Brambilla Michela , Maggiore Laura , Pomati Simone , Pantoni Leonardo
Published: January 2021

Background

During Covid-19 pandemic, the Italian government adopted restrictive limitations and declared a national lockdown on March 9, which lasted until May 4 and produced dramatic consequences on people’s lives. The aim of our study was to assess the impact of prolonged lockdown on behavioral and psychological symptoms of dementia (BPSD).

Methods

Between April 30 and June 8, 2020, we interviewed with a telephone-based questionnaire the caregivers of the community-dwelling patients with dementia who had their follow-up visit scheduled from March 9 to May 15 and canceled due to lockdown. Among the information collected, patients’ BPSDs were assessed by the Neuropsychiatric Inventory (NPI). Non-parametric tests to compare differences between NPI scores over time and logistic regression models to explore the impact of different factors on BPSD worsening were performed.

Results

A total of 109 visits were canceled and 94/109 caregivers completed the interview. Apathy, irritability, agitation and aggression, and depression were the most common neuropsychiatric symptoms experienced by patients both at baseline and during Covid-19 pandemic. Changes in total NPI and caregiver distress scores between baseline and during lockdown, although statistically significant, were overall modest. The logistic regression model failed to determine predictors of BPSD worsening during lockdown.

Conclusion

This is one of the first studies to investigate the presence of BPSD during SARS-CoV-2 outbreak and related nationwide lockdown, showing only slight, likely not clinically relevant, differences in BPSD burden, concerning mostly agitation and aggression, anxiety, apathy and indifference, and irritability.
Understanding the Risk of Human Immunodeficiency Virus (HIV) Virologic Failure in the Era of Undetectable Equals Untransmittable
Authors: Gunn Jayleen K. L. , Patterson Wendy , Anderson Bridget J. , Swain Carol-Ann
Published: January 2021

The “Undetectable = Untransmittable” campaign indicates that persons living with Human Immunodeficiency Virus (HIV) who maintain a suppressed viral load cannot sexually transmit the virus. However, there is little knowledge of the percent of individuals at a population level who sustain viral suppression long term. The aims of this study were to: (1) establish a baseline of persons living with diagnosed HIV who resided in New York and had consecutive suppressed viral load tests; (2) describe the risk of virologic failure among those who were consecutively suppressed; and (3) gain an understanding of the length of time between consecutive viral suppression to virologic failure. A total of 102,339 New Yorkers aged 13–90 years were living with diagnosed HIV at the beginning of 2012; 47.9% were consecutively suppressed (last two HIV viral load test results from 2010–2011 that were < 420 days apart and < 200 copies/mL). Of consecutively suppressed individuals, 54.3% maintained viral suppression for the entire study period and 33.6% experienced virologic failure during the study period. Among persons who experienced virologic failure, 82.6% did so six or more months after being consecutively suppressed. Our findings support the need for ongoing viral load monitoring, adherence support, and ongoing risk reduction messaging to prevent forward HIV transmission.
Primary School Students’ Knowledge of the Equal Sign—the Swedish Case
Authors: Madej Lars
Published: January 2021

This case study investigates, at three Swedish schools, primary school students’ knowledge of the equal sign. The schools were chosen as representatives of schools whose students have different socioeconomic backgrounds. The data consist of Grade 3 and 6 students’ responses to an assessment form based on Matthews et al. (JRME, 43(3):316–350, 2012). A comparison between the schools indicates that there are great differences in the students’ knowledge of the equal sign depending on which school they attend. The Swedish students perform better than South Korean students responding to the same assessment form when it comes to knowing that the equal sign does not mean an operation (“the answer to a problem”). We find this interesting to discuss, as South Korea is one of the countries that performs the best on the TIMSS and PISA.
Trauma: phenomenological causality and implication
Authors: Wilde Lillian
Published: January 2021

The relationship between traumatic experiences and subsequent distress is not well understood, and little research focuses on the lived experience of psychological trauma. I draw on Louis Sass’s phenomenological taxonomy to address this lacuna. I present his differentiation between relations of phenomenological causality and implication and demonstrate that his taxonomy can be applied to experiences of trauma. Relations of phenomenological causality and implication can be identified in the genesis and constitution of post-traumatic distress. My adaptation of Sass’s taxonomy will furthermore offer an extension and development of his account, applying it to the study of post-traumatic experiences and elaborating it in the process. I shall demonstrate that whether experiences occur synchronically or diachronically is not essential to their categorization in terms of phenomenological implication and causality, respectively. I will show that an alteration in perception or behavior post trauma might temporally succeed the traumatizing event while, at the same time, being implied in the experience of the event. Thereby, I demonstrate how phenomenology may contribute to a detailed understanding of experiences of trauma. Scrutiny of traumatic experiences furthermore promises to contribute to the philosophical discourse on causality, implication, and temporal experience.
Parental well-being in times of Covid-19 in Germany
Authors: Huebener Mathias , Waights Sevrin , Spiess C. Katharina , Siegel Nico A. , Wagner Gert G.
Published: January 2021

We examine the effects of Covid-19 and related restrictions on individuals with dependent children in Germany. We specifically focus on the role of day care center and school closures, which may be regarded as a “disruptive exogenous shock” to family life. We make use of a novel representative survey of parental well-being collected in May and June 2020 in Germany, when schools and day care centers were closed but while other measures had been relaxed and new infections were low. In our descriptive analysis, we compare well-being during this period with a pre-crisis period for different groups. In a difference-in-differences design, we compare the change for individuals with children to the change for individuals without children, accounting for unrelated trends as well as potential survey mode and context effects. We find that the crisis lowered the relative well-being of individuals with children, especially for individuals with young children, for women, and for persons with lower secondary schooling qualifications. Our results suggest that public policy measures taken to contain Covid-19 can have large effects on family well-being, with implications for child development and parental labor market outcomes.
No conversion, no conversation: consequences of retail salespeople disengaging from unpromising prospects
Authors: Cron William L. , Alavi Sascha , Habel Johannes , Wieseke Jan , Ryari Hanaa
Published: January 2021

On encountering a prospect whom they believe unlikely to make a purchase, some retail salespeople adopt a sales strategy of limiting engagement with the customer, relying on a “no conversion, no conversation” (NC2) sales strategy. Is this a good or bad sales strategy? Based on a multisource dataset combining salespeople and objective sales performance data, the authors examine retail salespeople’s performance consequences of disengaging from a customer, i.e., of the NC2sales strategy. Higher sales performance and sales growth arises from the use of an NC2sales strategy when (1) salespeople are experienced professionals skilled in gauging customers’ purchase likelihood, (2) store traffic is high, and (3) salespeople are oriented to building lasting customer relationships. However, (4) when store traffic is low and peers use the NC2sales strategy as well, this customer disengagement strategy yields lower returns for salespeople.
Factors Conditioning the Potential Effects TiO2 NPs Exposure on Human Microbiota: a Mini-Review
Authors: Baranowska-Wójcik Ewa
Published: January 2021

The recent years have seen a significant interest in the applications of nanotechnology in various facets of our lives. Due to their increasingly widespread use, human exposure to nanoparticles (NPs) is fast becoming unavoidable. Among the wide group of nanoparticles currently employed in industry, titanium dioxide nanoparticles, TiO2 NPs, are particularly popular. Due to its white colour, TiO2 is widely used as a whitening food additive (E 171). Yet, there have been few studies aimed at determining its direct impact on bacteria, while the available data suggest that TiO2 NPs may influence microbiota causing problems such as inflammatory bowel disease, obesity, or immunological disorders. Indeed, there are increasing concerns that its presence may lead to intestinal barrier impairment, including dysbiosis of intestinal microbiota. This article aims to present an overview of studies conducted to date with regard to the impact of TiO2 NPs on human microbiota as well as factors that can affect the same. Such information is necessary if we are to conclusively determine the potential toxicity of inorganic nanoparticles.
Improvement of Rat Spinal Cord Injury Following Lentiviral Vector-Transduced Neural Stem/Progenitor Cells Derived from Human Epileptic Brain Tissue Transplantation with a Self-assembling Peptide Scaffold
Authors: Abdolahi Sara , Aligholi Hadi , Khodakaram-Tafti Azizollah , Khaleghi Ghadiri Maryam , Stummer Walter , Gorji Ali
Published: January 2021

Spinal cord injury (SCI) is a disabling neurological disorder that causes neural circuit dysfunction. Although various therapies have been applied to improve the neurological outcomes of SCI, little clinical progress has been achieved. Stem cell–based therapy aimed at restoring the lost cells and supporting micromilieu at the site of the injury has become a conceptually attractive option for tissue repair following SCI. Adult human neural stem/progenitor cells (hNS/PCs) were obtained from the epileptic human brain specimens. Induction of SCI was followed by the application of lentiviral vector-mediated green fluorescent protein–labeled hNS/PCs seeded in PuraMatrix peptide hydrogel (PM). The co-application of hNS/PCs and PM at the SCI injury site significantly enhanced cell survival and differentiation, reduced the lesion volume, and improved neurological functions compared to the control groups. Besides, the transplanted hNS/PCs seeded in PM revealed significantly higher migration abilities into the lesion site and the healthy host tissue as well as a greater differentiation into astrocytes and neurons in the vicinity of the lesion as well as in the host tissue. Our data suggest that the transplantation of hNS/PCs seeded in PM could be a promising approach to restore the damaged tissues and improve neurological functions after SCI.
Cholinium amino acid-based ionic liquids
Authors: Le Donne Andrea , Bodo Enrico
Published: January 2021

Boosted by the simplicity of their synthesis and low toxicity, cholinium and amino acid-based ionic liquids have attracted the attention of researchers in many different fields ranging from computational chemistry to electrochemistry and medicine. Among the uncountable IL variations, these substances occupy a space on their own due to their exceptional biocompatibility that stems from being entirely made by metabolic molecular components. These substances have undergone a rather intensive research activity because of the possibility of using them as greener replacements for traditional ionic liquids. We present here a short review in the attempt to provide a compendium of the state-of-the-art scientific research about this special class of ionic liquids based on the combination of amino acid anions and cholinium cations.
Discharge coefficient of flow over Al-Shalalat stepped weir on Al-Khusr River
Authors: Altalib Azza N.
Published: January 2021

Many hydraulic structures are constructed in an open channel according to the purposes and the nature of the region. Weir is one of these structures which is used for discharge measurements as well as rising water depth in irrigation channels. According to the crest, there are two different shapes: sharp and broad crested weir. A stepped weir is constructed to reduce scour that happened downstream. There are different studies dealt with discharge coefficient, energy dissipation, and other hydraulic characteristics for flow over the weir. In this study, the coefficient of discharge for the Al-Shalalat stepped weir on the Al-Khusr River has been evaluated. The discharge coefficient equation is predicted, and the result values are compared with previous studies. The percentage error for the predicted discharge equation presented in this study compared with previous studies does not exceed 10%.
Zur Komorbidität von Posttraumatischer Belastungsstörung und Sucht in biopsychosozialer Perspektive
Authors: Kapfhammer Hans-Peter
Published: January 2021

Posttraumatische Belastungsstörung und Substanzkonsumstörungen treten im medizinischen Versorgungssystem häufig koexistent auf. Ihre Komorbidität geht mit schwerwiegenderen akuten klinischen Symptombildern, mit zahlreichen, oft notfallmäßigen Hospitalisierungen und geringeren Behandlungserfolgen einher. Ihre Komorbidität trägt zu dramatisch ungünstigeren Verläufen auf allen biopsychosozialen Ebenen bei. Das Thema Komorbidität von PTBS und Sucht wird auf mehreren Ebenen untersucht: in den Perspektiven von Epidemiologie, Substanzkonsumstörung als Risikofaktor für Trauma und PTBS, Trauma und PTBS als Risikofaktor für Substanzkonsumstörung, neurobiologischen Konsequenzen einer Substanzkonsumstörung für die Neurobiologie von PTBS, gemeinsam geteilten Faktoren der Genetik/Epigenetik, Persönlichkeitsdimensionen und aversiven/traumatogenen Einflüssen in der frühen Entwicklung. Der Hauptfokus der Analyse liegt auf den wechselseitig sich verstärkenden Mechanismen, die der Entwicklung und dem Verlauf beider Störungsbilder inhärent sind.
Effects of road traffic on photosynthetic pigments and heavy metal accumulation in tree species of Kumasi Metropolis, Ghana
Authors: Uka Ufere N. , Belford Ebenezer J. D. , Elebe Florence A.
Published: January 2021

This study was undertaken to examine changes in the content of pigments and accumulation of metals from vehicular pollution in selected species of roadside trees under vehicular pollution. A major arterial road with heavy vehicle emissions in the Kumasi Metropolis was designated as the polluted site, while Kwame Nkrumah University of Science and Technology Campus was designated as the control site. Four tree species (Terminalia catappa, Mangifera indica, Ficus platyphyllaandPolyalthia longifolia) selected for the study were well distributed and abundant in the polluted and control sites. Photosynthetic pigments and levels of heavy metals (Pb, Cu, Cd and zinc) were assessed in their leaves. Chlorophyll and carotenoid contents were determined by absorption spectrometry, while the metal accumulation index (MAI) was used to determine the total metal accumulation capacity of the tree species. We observed a reduction in photosynthetic pigments in the leaf samples from the polluted site.Ficus platyphyllahad the maximum reduction in total chlorophyll (49.34%), whereasTerminalia catapparecorded the lowest reduction (33.88%). Similarly, the largest decrease (31.58%) of carotenoid content was found inTerminalia catappatrees and the lowest inPolyalthia longifolia(16.67%). ThePolyalthia longifolia, Ficus platyphyllaandTerminalia catappaleaf samples collected at the polluted site recorded a higher ratio of chlorophyll a/b. Heavy metal (Cu, Pb, Zn and Cd) accumulation in leaf samples was higher in the polluted site than in the control, as expected. The highest metal MAI value was recorded inMangifera indica(5.35) followed byPolyalthia longifoliawith 4.30. The findings from this study specifically demonstrate that air contamination induced by vehicles decreases the level of photosynthetic pigments in trees subjected to roadside emissions. It is clear that both chlorophyll a/b and chlorophyll/carotenoid ratios will act as very useful stress-level markers. Elevated heavy metal levels in the tree species along arterial roadsides indicate that they serve as heavy metals sink. The change in MAI resulting from different pollution burden is an indication that the removal capabilities of the tree species differ from each other. We therefore suggestM. indicaandP. longifoliaas potential species to be used in air pollution reduction plans in the city.