bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPUTATIONAL POLLUTANT OF SO2/NO2 IN THE ENVIRONMENT USING AERMOD IN SEMI-URBAN AREA, STUDI CASE IN TUBAN, EAST JAVA
Authors:   Departemen of Environmental Engineering, Institut Teknologi Sepuluh Nopember., a Krisbiantoro , Dipareza Syafei Arie ,   Departemen of Environmental Engineering, Institut Teknologi Sepuluh Nopember., Fadli Assomadi Abdu ,   Departemen of Environmental Engineering, Institut Teknologi Sepuluh Nopember.
Published: March 2022

Air pollution is a problem that often occurs in Indonesia, especially in cities where the industry is growing rapidly, such as Tuban City. This is due to the low level of environmental management planning, including air quality management. Many models can be used to predict pollutant concentrations in ambient air. Currently, the model often used is Meteorological Forecast Models, one of which is AERMOD. The effort made here is to evaluate the performance of the AERMOD (AERMOD + Background concentration) model. The AERMOD model was used to predict ambient air quality in Tuban, East Java, and evaluated using ratio-to-observer, MAPE, and relative mean bias values. Air quality modeling was carried out in the rainy and dry seasons in 2018 and 2019. The modeling results using the AERMOD model resulted in an acceptable model. The results of the NO2 parameter modeling result in an overpredicted model trend, and changes in grid size affect the MAPE value and the resulting relative means bias. Meanwhile, the SO2 parameter modeling results produce a model that tends to be underpredicted, and the change in grid size does not have a significant effect. The performance evaluation of the model is expected to be useful for air quality management and further development of this model.
AN ANALYSIS OF THE PROBIOTIC BACTERIA IN THE COMMONLY FERMENTED MAIZE, OIL BEAN, AND CASTOR OIL IN NIGERIA
Authors:   Department of BiologyFederal College of Education, Eha Amufu., O. Eze Simon
Published: March 2022

Active probiotic organisms are essential bacteria considered live microorganisms obtained from fermented foods. There is increasing evidence that probiotics are necessaryfor human health. This study aimed to isolate and characterize the active probiotic microorganisms in Nigerias commonly fermented food samples. Maize, castor oil,and African oil beans were the primary fermentable food samples used in the study. The result revealed the presence of active probiotic organisms such as Pedioccocus, Micrococcus,Lactobacillus, and Bacillus species. The study concluded that these organisms are responsible for the fermentation of carbohydrates and protein-rich seeds.
ATTITUDE TOWARDS POLITICAL ENGAGEMENT AMONG WOMEN IN SOUTHEAST NIGERIA
Authors:   Department of Social Studies Federal College of Education (Technical) Umunze., Sabina Chinyere Onwuasoanya
Published: March 2022

The political landscape of Nigeria and the world, in general, has witnessed a declined presence of women in the system. The trend has generated considerable concern from numerous scholars. However, a growing intimation suggests that women are currently making headways to politics. This development is evident in the political arena of southeast Nigeria. Thus, the papers purpose was to explore the overall attitudes of women in the southeast towards political participation. Five hundred and sixteen women were randomly pooled from different locations in three southeast states to participate in the study. The respondents completed a self-report measure of attitude towards political participation. The result indicates that a majority of the respondents,78.3% with MD=0.98, showed a positive attitude towards political participation than 21.7% of their counterparts. It concluded that attitude is an essential component in the women-politics relationship. It is recommended that women be supported to participate in political business.
CORRELATION BETWEEN ECONOMIC HARDSHIP AND INTENTION TO QUIT AMONG SMALL BUSINESSES OWNERS IN THE POST COVID BUSINESS
Authors:   Department of Economics Federal College of Education, Eha Amufu., Nwanonyere Chika
Published: March 2022

Small business has contributed significantly to the economic growth of any society and has assumed a ubiquitous part of the business ecosystem. Conceivably, it contributes positively to job creation and has been widely considered the primary engine of socioeconomic development and wealth creation. However, there are indications that the post-Covid-19 business era has been unfavorable to small businesses. Thus, the purpose of the present paper was to examine the correlation between economic hardship and intention to quit among small business owners. A convenience sample of one hundred and fourteen entrepreneurs pooled from different business hubs in the Enugu state of Nigeria participated in the study. The Pearsons product-moment correlation analyses indicated a statistically significant, moderate positive correlation between intention to quit and economic hardship, r (112) = .39, p < .001, with economic hardship explaining 24% of the variation in intention to quit. Thus, the result supports the assumption of the study.
CORRELATION BETWEEN RELIGIOUS COMMITMENT AND HEALTHCARE SEEKING BEHAVIOR AMONG THE YOUTH IN SOUTHEAST NIGERIA
Authors:   Department of Christian Religious Studies Federal College of Education., C. Nwoko Chrisanctus , Amufu Camilus O. Udaya Eha ,   Department of Christian Religious Studies Federal College of Education, Eha Amufu.
Published: March 2022

Religion is widely understood to play an essential role in young peoples behaviors, making it a significant factor in the discourse on youth health-promoting behaviors. Perhaps, there isa growing indication that young people are less likely to engage in health-promoting behaviors. The present study examined the role of religious commitment on the health-seeking behaviors of the youth in southeast Nigeria. Three hundred and nineteen respondents randomly selected from three states (Enugu, Anambra, and Ebonyi states) participated in the study. The participants completed a self-report measure of health-seeking behavior and religious commitment inventory. The simple regression analysis conducted on the data revealed that RC significantly predicted HSB. The study concludes that RC is an essential correlate of HSB in youth. Policymakers and healthcare providers can use religious institutions to promote positive health behavior among youth in southeast Nigeria.
CORRELATION BETWEEN THE PROLONGED COVID-19 LOCKDOWN AND ACADEMIC REGRESSION AMONG SECONDARY SCHOOL STUDENTS IN ENUGU STATE
Authors:   Department of Guidance and Counseling Federal College of Education, Eha Amufu., I. Omatalu Daniel , N. Ikwuegbu Pauline ,   Federal College of Education, Eha Amufu.
Published: March 2022

The emergence of the Covid-19 virus represents an unprecedented global health crisis that affected every human endeavor. Intimations suggest that the prolonged lockdown occasioned by the dreaded coronavirus pandemic may have triggered academic regression among school students, especially at the secondary education level in Nigeria. Based on this, we conducted this study to explore if there would be a significant relationship between the prolonged school break and academic regression among a sample of secondary school students in Enugu State, Nigeria. A convenience sample of three hundred and eighteen students randomly pooled from secondary schools participated in the study. The participants completed a self-report measure of the Academic Regression Inventory. The result of Pearsons correlation revealed a significant positive relationship between the prolonged academic break and academic regression. The findings, implications, and conclusion are discussed.
EFFECT OF AUDITING SKILLS ON SMALL BUSINESS PERFORMANCE: A STUDY OF SMALL BUSINESSES IN ANAMBRA STATE, NIGERIA
Authors:   Department of Business Education Federal College of Education, Technical, Anambra State, Nigeria., C. Ochuba Daniel
Published: March 2022

Small and medium-scale enterprise is a ubiquitous part of the business world. SMEs have been widely implicated in the growth and development of the Nigerian economy. However, the sector has been fraught with several challenges. Indeed, financial management is one of the primary limitations associated with the collapse and underperformance of small businesses. Thus, the present study aimed to investigate the performance of SMEs in the Anambra State of Nigeria based on auditing skills. The study adopted a cross-sectional survey. A total of seventy-nine small and medium-scale operators were randomly selected from the Onitsha business hub participated in the study. A self-developed instrument was used as a measure. Simple linear regression analysis was used for data analysis, and it was found that auditing skills significantly predicted SME performance. Implications and recommendations are discussed.
EFFECT OF EMPLOYEES ICT SKILLS ON THE PERFORMANCE OF MANUFACTURING FIRMS IN SOUTHEAST NIGERIA
Authors:   Department of Business AdministrationFederal College of Education (Technical) Umunze., I. Okoli David
Published: March 2022

The manufacturing firms are among the relevant sectors that contribute positively to the growth and development of the Nations economy. Perhaps, one of the major concerns of the manufacturing firms is to maximize performance and compete efficiently in the market. However, there is growing intimation on the poor performance of many manufacturing industries in the South-east region of Nigeria. Thus, the current study aimed to investigate the performance of manufacturing firms based on the ICT skills of the employees. One hundred and nine employees from different departments in various manufacturing firms responded to the research instrument designed to measure ICT competence and two performance domains. A simple linear regression was conducted on the data, and the result indicated a statistically significant association between employeesICT skills and increased performance of the firms. The finding, implications, and conclusions are discussed.
EFFECT OF THE RETAIL ENTERPRISE ADOPTED COVID-19 PROTECTIVE PROTOCOLS ON CUSTOMERS PURCHASING INVOLVEMENT
Authors:   Department of Business Education Federal College of Education, Eha Amufu., E. bi Paul
Published: March 2022

The ongoing COVID-19 pandemic has altered how many things are done in every aspect of the world. The retail enterprise is an essential component of the business ecosystem that depends heavily on face-to-face and in-person interaction for an efficient transaction. However, the measures instituted against the spread of the virus can potentially disrupt consumers shopping routing. The present study sought to examine the effect of the protective measures established by the retail enterprise against the COVID-19 disease on the customers purchasing involvement. A convenient sample of two hundred and forty-eight potential consumers selected from various locations in Enugu State, Nigeria, participated in the study. The regression analysis performed on the data revealed that the COVID-19 measure adopted by the retail enterprise positively predicted customer purchase involvement. The finding provides valuable data to researchers and retail practitioners to develop a framework that could stabilize customers purchasing participation in a positive direction.
ENTREPRENEURIAL MOTIVATION AS A PREDICTOR OF ATTITUDE TOWARDS TRAFFIC SAFETY AMONG MINIBUS DRIVERS IN ANAMBRA STATE
Authors:   Department of Business EducationFederal College of Education, Technical, Umunze., Uzo-Okonkwo Helen
Published: March 2022

Within entrepreneurship, motivation describes the psychological investment geared towards attaining a set business goal. Indeed, motivation is an essential component in the transportation business. Given the increasing disregard for traffic safety associated with the transportation business in Nigeria, research must explore the relevant variables that could correlate the behavior of motorists towards traffic safety. Thus, the purpose of the present study is to examine entrepreneurial motivation as a factor that could account for the variation in attitudes towards traffic safety among minibus drivers in the Anambra State of Nigeria. One hundred and thirteen minibus operators operating in different locations in the state were recruited for the study. The participants comprised males within the age range of 20 to 45 years with about one year of driving experience. They completed a self-report measure of the Attitude towards Safe Driving Scale (ASDS) and the entrepreneurial motivation questionnaire. The simple regression analysis conducted on the data revealed that entrepreneurial motivation statistically significantly predicted attitudes towards traffic safety. Thus, the study concluded that entrepreneurial motivation is an essential determinant of drivers attitudes towards traffic safety.
FOOD SKILLS AS A PREDICTOR OF HEALTHY FOOD CHOICE AMONG THE FEMALE UNDERGRADUATES IN NIGERIA
Authors:   Department of Home EconomicsFederal College of Education (Technical) Umunze., O. Emere Delphine
Published: March 2022

There are indications that female undergraduates in tertiary institutions in Nigeria undergo a life transition that results in poor dietary behaviors and weight gain. Adequate food skills may improve dietary preference and prevent overweight among females. However, research is limited on students food skills and food-related behaviors in the present context. The objective of this study was to assess whether food skills would predict healthy food choices of female undergraduates using a cross-sectional online survey. The participants comprised female students pooled from five public and private tertiary institutions in the Anambra and Enugu state of Nigeria. The respondents completed self-report measures. The result revealed a statistically significant interaction between food skills and food choice. Thus, it was recommended that food skills are an essential determinant of healthy food choices. The implication of the study is discussed.
SOCIO-CULTURAL CORRELATES OF STUDENTS INTEREST IN ENGLISH AS A SECOND LANGUAGE
Authors:   Department of English Federal College of Education (Technical) Umunze., Onunkwor Benedetta
Published: March 2022

English is the official language in Nigeria and a ubiquitous part of teaching and learning in the educational ecosystem. However, English as a second language in Nigeria has been fraught with many challenges. The purpose of this present study was to examine the sociocultural correlates of students interest in ESL. Two hundred and thirty secondary school students (n=230) were conveniently selected from rural and urban schools in the Anambra States as the respondents. Data for the survey was collected using a self-report measure assessing interest in ESL. Linear regression analysis was conducted on the data, and the result showed that sociocultural context statistically significantly predicted interest in ESL. The study concludes that the sociocultural environment is a significant determinant of students interest in ESL in Anambra State.
CONTRIBUTION OF ENDOSCOPIC ULTRASOUND IN PANCREATIC MASSES
Authors:   Hepato-Gastroenterology Department, Hassan II University Hospital, Fez, Morocco., Figuigui Mouna , Abid Hakima ,   Hepato-Gastroenterology Department, Hassan II University Hospital, Fez, Morocco., Lamine Asmae ,   Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco., Lahlali Maria ,   Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco., Lahmidani Nada ,   Hepato-Gastroenterology Department, Hassan II University Hospital, Fez, Morocco., El Yousfi Mounia ,   Hepato-Gastroenterology Department, Hassan II University Hospital, Fez, Morocco., Adil Ibrahimi Sidi ,   Hepato-Gastroenterology Department, Hassan II University Hospital, Fez, Morocco., El Abkari Mohammed ,   Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco., Benajah Dafr-Allah ,   Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Published: March 2022

Endoscopic ultrasound (EUS) is a method of exploration of the digestive system that combines two techniques: endoscopy and ultrasound. EUS has several applications in digestive pathology. Echo-endoscopic biopsy (EEB) of pancreatic masses is a technique that allows fine needle aspiration to obtain material for cytohistological analysis. It is indicated each time a histological examination can have a diagnostic and/or therapeutic interest.For that we realized a retrospective study between January 2017 and December 2020. All patients referred to the department for a bilio-pancreatic echo-endoscopy in the framework of a pancreatic tumor were included in the study. We collected 90 patients who met our inclusion criteria. We recorded the patients demographics, pathologic history, symptoms, and ultrasound, CT, and EUS. During the echo-endoscopic examination, we always tried to specify some essential data according to the international recommendations, depending on the pathology (benign or malignant).
PEDIATRIC PELVIC FRACTURES: AREVIEW ARTICLE AND A CASE REPORT
Authors:   Orthopedic Resident, MBBS, Saudi Arabia., Albohair Anjoud , Saleh Hosny ,   Consultant Orthopeadic Surgeon, King Fahd Military Medical Complex, Saudi Arabia.
Published: March 2022

Introduction:Pediatric pelvic fractures are most commonly associated with high energy fractures, mostly due to motor vehicle accidents. Children poorly tolerate any significant blood loss, so, any child presents with a pelvic fracture must be investigated for multi-organ injury, or possible life -threatening retroperitoneal hemorrhage, with an increased potential for death. Method: A literature search was conducted to included articles from 2001 till 2017on pediatric pelvic fracture, including stable and unstable fractures, acetabular, and sacroiliac joint injuries, and excluded adult population. Results: Conservative management is the main treatment in hemodynamically stable patients, with good anatomical reduction, however , in a hemodynamically unstable patients, external fixator is the gold standard as a temporary management.This, most often is followed by open or closed reduction with internal fixation by screws only or plates and screws, which is consistent with achieving early stability, better union rates and hence early return to normal daily activities.
DETAILING DENGUE - A STUDY OF CLINICAL AND LABORATORY PROFILE OF DENGUE PATIENTS IN A TERTIARY CARE CENTRE
Authors:   Assistant Professor, Department of General Medicine, Dr.Pinnamaneni Siddhartha Medical College,Chinoutpally, Andhra Pradesh., Sumanth Kumar K. , Sirisha Y. ,   Associate Professor, Department of General Medicine, Dr.Pinnamaneni Siddhartha Medical College,Chinoutpally, Andhra Pradesh., Madhukiran Reddy B. ,   Associate Professor, Department of General Medicine, Dr.Pinnamaneni Siddhartha Medical College,Chinoutpally, Andhra Pradesh., Krishna Nukala Prudhvi ,   Post Graduate, Department of General Medicine, Dr.Pinnamaneni Siddhartha medical college, Chinoutpally, Andhra Pradesh.
Published: March 2022

Background: Dengue is one of the most rapidly spreading mosquito-borne viral disease with a rapid increase in incidence in recent decades. It is a major public health concern throughout India.The objective of this study is to review the clinical manifestations and laboratory profile of dengue cases admitted in a tertiary care hospital, near Vijayawada, Andhra Pradesh.This data would help us know and compare the inter annual variation in dengue presentation in forthcoming dengue epidemics. Methods:This is a retrospective study carried out from 1st January 2021 to 31st December 2021 in Dr.PinnamaneniSiddhardha medical college , Chinnoutpalli ,Andhra Pradesh. Patients above 18 years of age admitted with acute febrile illness and tested positive for NS1Ag or Dengue IgM were taken into study.The required data regarding their clinical presentation , haematological and biochemical profile was collected and analysed. Results: The most common clinical presentation of dengue in our study was fever (97%) followed by myalgia (70%), headache (69%)arthralgia (45%), rash (29%), diarrhoea (10%)retro-orbital pain (7%),nausea and vomiting (3%).34% of patients had leucopenia.25% and 5% of patients had transaminitis and elevated renal parameters respectively Conclusions: Dengue commonly affected the male and young population. Fever, headache, myalgia ,thrombocytopenia and leukopenia were common presenting features with few patients having transaminitis and elevated renal parameters.
THYROID-LIKE FOLLICULAR CARCINOMA OF THE KIDNEY IN A CHRONIC DIALYSIS PATIENT: ONE CASE REPORT AND REVIEW OF THE LITERATURE
Authors:   Department of Pathological Anatomy, IbnSina Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Benbella L. , Benbella M. ,   Department of Nephrology and Hemodialysis, IbnSina Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Abidi H.El ,   Department of Urology A, IbnSina Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Ibrahimi A. ,   Department of Urology A, IbnSina Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Nouini Y. ,   Department of Urology A, IbnSina Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Zouaidia F. ,   Department of Pathological Anatomy, IbnSina Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Published: March 2022

Thyroid-like follicular carcinoma of the kidney (TLFCK) is an extremely rare subtype of renal cell carcinoma (RCC) that histologically mimics primary follicular carcinoma of the thyroid gland. This new entity has not yet been integrated into the current WHO classification of renal tumors due to the limited data available. We report a further case of this rare histological entity, discuss the clinical, histological and immunohistochemical findings and provide an update on the review of the literature. A 73-year-old woman was found to have a left renal mass during her annual medical checkup. Her past medical history included high blood pressure and renal failure at hemodialysis stage. The patient underwent a nephrectomy with simple postoperative course. The tumor was described as being round, well circumscribed and dark brown in color. Histologically, the tumor showed follicular architecture with macro and micro follicles containing eosinophilic secretions or colloid-like material. Immunohistochemical studies demonstrated that the tumor cells exhibited no immunoreactivity for thyroid transcription factor-1 and thyroglobulin. The tumor cells showed intensive staining for cytokeratin 7 (CK7). The tumor cells were completely negative for CK20, WT1 and PAX8. Molecular biology was not carried out for lack of means. These findings are dissimilar to previously classified renal neoplasm. Thyroid-like follicular renal cell carcinoma represents a unique histologic subtype of renal cell carcinoma of low malignant potential and its primary importance is to distinguish it from metastatic carcinoma from the thyroid. A correct histopathologic diagnosis has important clinical and therapeutic implications. The current consensus from ISUP is not to recommend TLFCK as a new WHO histologic classification due to the small number of cases therefore, documentation of all cases available seems to be important to gain additional knowledge.
THE EVOLUTION OF CAR T-CELL THERAPY: ETHICS AND EFFICIENCY
Authors:   Singapore American School, 40 Woodlands Street 41, Singapore 738547., Khemani Sara , Badar Jumana ,   Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, 14850, USA.
Published: March 2022

Engineering T cells with a chimeric antigen receptor (CAR) that reprograms their antigen selectivity and signalling has recently emerged as one of the most promising therapeutic approaches for treating cancers. The initial emergence and the evolution of this treatment has significantly contributed to its success. However, it is not known if the advancement of this technology is accompanied with any socio- economic or ethical concerns. This paper will first dive into the scientific evolution of CAR T-cell therapy as mode of cancer treatment. In addition, this paper will also describe the basic structure of the CAR and discuss how each of its domains affect the efficacy and safety of CAR-T therapies. It will also highlight the changing landscape of ethical concerns raised by CAR T-cell therapy. Overall, this paper analyzes how the advancement in CAR T-Cell therapy has or will impact public opinion and health.
HOUPHOUET-BOIGNYS INTEGRATIONIST POLICY AND THE INTEGRATION OF LEBANESE IN COTE DIVOIRE (1960-1993)
Authors:   Departement dhistoire Universite Peleforo Gon Coulibaly de Korhogo, Cote dIvoire., Adolphe Ngoran Kouadio
Published: March 2022

Felix Houphouet-Boigny was President of the Republic of Cote dIvoire between 1960 and 1993. During his reign, he undertook a policy of openness which encouraged a large number of foreign immigrants, including Lebanese from the Middle East. According to the 1988 Population and Housing Census, foreign communities, dominated by West Africans, represented 28% of the total population. Alongside these, there is a minority from the Middle East, the Lebanese. In fact, present in the country since the beginning of colonisation, they are rooted and have strengthened their economic and social position during the post-colonial period. Drawing on oral and printed sources, books and articles, this study analyses the actions of Felix Houphouet-Boigny on the Levantine community from 1960 to 1993. This work first presents the actions of President Felix Houphouet-Boigny and then their economic and social consequences on the Lebanese in Cote dIvoire.
LOWER EXTREMITY PHERIPHERALARTERIAL DISEASE - AN UPDATE
Authors:   Ph.D. Scholar, Annamalai University., Sunitha Therese S. , Gayathri N. ,   Lecturer in Nursing, Rani Meyyammai College of Nursing.
Published: March 2022

Lower-extremity arterial disease (LEAD) is a major endemic disease with an alarming increased prevalence worldwide. It is a common and severe condition with excess risk of major cardiovascular events and death. It also leads to a high rate of lower-limb adverse events and non-traumatic amputation. The American Diabetes Association recommends a widespread medical history and clinical examination to screen for LEAD. The ankle brachial index (ABI) is the first non-invasive tool recommended to diagnose LEAD although its variable performance in patients with diabetes. The performance of ABI is particularly affected by the presence of peripheral neuropathy, medial arterial calcification, and incompressible arteries. There is no strong evidence today to support an alternative test for LEAD diagnosis in these conditions. The management of LEAD requires a strict control of cardiovascular risk factors including diabetes, hypertension, and dyslipidaemia. The benefit of intensive versus standard glucose control on the risk of LEAD has not been clearly established. Antihypertensive, lipid-lowering, and antiplatelet agents are obviously worthful to reduce major cardiovascular adverse events, but few randomised controlled trials (RCTs) have evaluated the benefits of these treatments in terms of LEAD and its related adverse events. Smoking cessation, physical activity, supervised walking rehabilitation and healthy diet are also crucial in LEAD management. Several advances have been achieved in endovascular and surgical revascularization procedures, with obvious improvement in LEAD management. The revascularization strategy should take into account several factors including anatomical localizations of lesions, medical history of each patient and operator experience. Further studies, especially RCTs, are needed to evaluate the interest of different therapeutic strategies on the occurrence and progression of LEAD and its related adverse events in patients with diabetes.
PEMPHIGOID GESTATIONIS : REPORT CASE AND LITERATURE REVIEW
Authors:   Department of Gynecology and Obstetric and Endoscopy, Maternity Souissi Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco., Imane Benmouna , Soukaina Cherradi ,   Department of Gynecology and Obstetric and Endoscopy, Maternity Souissi Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco., Amina Lakhdar ,   Department of Gynecology and Obstetric and Endoscopy, Maternity Souissi Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco., Najia Zeraidi ,   Department of Gynecology and Obstetric and Endoscopy, Maternity Souissi Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco., Aziz Baidada ,   Department of Gynecology and Obstetric and Endoscopy, Maternity Souissi Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Published: March 2022

Pemphigoid gestationis is a gravidic dermatosis usually appearing between the 28th and 32nd week of amenorrhea. The rash is pruritic, bullous or vesiculopapular and of periumbilical topography. In addition to clinical findings, Thediagnosis is confirmed by direct immunofluorescence. If local treatment fails, systemic corticosteroid therapy should be administered. Oral corticosteroids are the therapeutic mainstay in pregnancy and postpartum.. Consequences may be maternal (threat of premature delivery), fetal (intrauterine growth retardation), and neonatal (skin rash). Through this observation and a review of theliterature the authors will try to focus on the physiopathology, clinicalprofile, immunological diagnosis, treatment and evolution of PG.
Som Tradition for Interreligious Harmony and Natural Preservation
Authors: Yusuf Muhamad , Sileuw Marwan , Muhandy Rachmad Surya , Mulyanita Novita
Published: March 2022

The article particularly portrays and studies the Matbat tribe. The Matbat tribe inhabitants establish a system to unite the Matbat people to create stability and peace in overcoming external situations. The intriguing part of the Matbat tribe is that they, starting from an individual level, keep preserving their communal tradition to sustain peace among them and defend their territory. The customary structure of the Matbat people in West Misool was created based on mutual agreement with the roles, duties and functions that are obtained to maintain balance and harmony aimed at kinship values. There are various symbols in the implementation of the Som, which act as a vehicle of conception that has a meaning as mediation that is actualization in daily life. Som's tradition is a unifying tool for the Matbat indigenous people. The procedures for implementing the tradition are determined by customs arranged in the Matbat customary structure. The Som tradition is an annual event held by the villagers and has the power of customary law that regulates the two villages. The Som tradition is carried out from generation to generation. It develops into values firmly held by the indigenous peoples, not only as their perspective on natural resource management policy. It also as the respect of the Younger Brother (Magey village, which is Protestant Christian) to the Elder Brother (Gamta village, which is Muslim), and as a collective awareness composed in creating a moral balance for indigenous peoples to maintain harmony.
Effect of the geometrical parameters on the vehicle's moving stability
Authors: Ye Xiaobin , Nguyen Vanliem , Ke Mingrui
Published: March 2022

To enhance the moving stability and safety of vehicles, kinematics and dynamics model of the vehicle consisting of a guided front wheel and a free rear wheel is established based on the model of a four-wheeled vehicle when the vehicle moves on the curve-road. The effect of the geometrical parameters and dynamics parameters including the factor of the moving stability, vehicle moving speed, lateral stiffness parameters of the front and rear wheels, vehicle mass, vehicle length on the vehicle moving stability and safety is then simulated and analyzed, respectively. The research results indicate that the operating parameters of the vehicle greatly affect the vehicle moving stability. The lateral stiffness parameters of the front and rear wheels should be increased while the vehicle mass needs to be reduced in the operating condition of the vehicle to enhance the vehicle moving stability. Besides, the vehicle lengthLshould be reduced and the longitudinal distance of a needs to be distributed by 0.95×ato further improve the vehicle moving stability.
Nonlinear dynamic analysis of constant-speed and variable-speed of autonomous vehicle passing uneven road
Authors: Yang Zhiyong , Wang Long , Liu Fangtao , Li Zijian
Published: March 2022

This paper focuses on the research about the comfort and safety of autonomous vehicles passing consecutive speed control humps (SCHs) at a highway, compares and analyzes the nonlinear dynamic characteristics of vehicles driving on uneven roads at a constant speed or with accelerations or decelerations. Firstly, a speed coupling excitation model of the consecutive SCHs and a four-degree-of-freedom (4-DOF) nonlinear vehicle suspension model are established, and then the numerical simulation is carried out by using the four-order fixed-step Runge-Kutta algorithm. The nonlinear dynamic characteristics are analyzed by means of a bifurcation diagram, phase portrait, Poincaré map, time history and power spectrum. Through the analysis, the relevant nonlinear motion characteristics and the speed critical conditions of chaotic vibration of autonomous vehicle suspension under these three conditions are obtained. The results show that chaotic motion may occur when the vehicle passes the uneven road in all three cases, and motion is not periodic during acceleration. Therefore, the vehicle should not accelerate passing continuous SCHs. The experimental results provide support for the follow-up researches of autonomous vehicle, because they give information on how to avoid chaotic motion, speed adaptive control, driving comfort and driving safety.
Communities of Practice: Doing Design Differently
Authors:   Monash University, McEntee Kate
Published: March 2022

This paper reflects on the role of communities of practice in building and supporting critical alternatives to conventional, Dominant Design (Akama, 2021; Rosner, 2018). Dominant Design refers to design practices cultivated within our industrialised, imperialist, patriarchal, capitalist modernity. Discourses and practices addressing this include decolonising design, stemming from modernity/coloniality critique and Indigenous knowledge systems, and anti-oppressive frameworks for design, based in anti- racism and Black feminist scholarship. These discourses at the margins of the dominant discourse and practice recognise the need for critical alternatives to design practices (Abdulla et al., 2019; Costanza-Chock 2018; Mignolo 2007; Schultz et al., 2018). This paper considers communities of practice as one way of practicing with the challenges of overwhelm, fear and lack of understanding and resources when pursuing decolonising and anti-oppression discourse and practice. The paper discusses the importance of practice as an ethic, and the role of spaces for rehearsing, experimenting with new types of doing, while being held accountable in community.
Palliative Care and Pulmonary Arterial Hypertension
Authors: Rhee Laura S. , Morgan Alisha A. , DuBrock Hilary M.
Published: March 2022

Background

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease associated with impaired health-related quality of life and survival. Palliative care (PC) is patient- and family-centered care provided by an interdisciplinary team with an overarching goal of alleviating suffering and improving quality of life for patients with advanced illness. PC in other chronic diseases is associated with improved quality of life, symptom management, illness understanding, and reduced caregiver burden, but there is limited data regarding PC in PAH. Despite limited evidence, there is strong rationale for involving PC specialists in the longitudinal management of PAH.

Implications for Clinicians

There are currently no guidelines to help clinicians determine the most appropriate timing for referral of PAH patients to PC specialty teams. Consequently, referrals are limited and often delayed. Adoption of a standardized approach to PC referrals based on clinical or patient triggers could facilitate earlier involvement of PC as an adjunct to ongoing PAH disease-directed care.

Conclusions

Incorporation of PC in the longitudinal management of PAH may be beneficial to address the multidimensional aspects of living with a chronic and life-limiting illness.
Selected Phytochemicals to Combat Lungs Injury: Natural Care
Authors: Samadder Asmita , Nandi Sisir , Dey Rishita
Published: March 2022

The human has two lungs responsible for respiration and drug metabolism. Severe lung
infection caused by bacteria, mycobacteria, viruses, fungi, and parasites may lead to lungs injury.
Smoking and tobacco consumption may also produce lungs injury. Inflammatory and pain mediators
are secreted by alveolar macrophages. The inflammatory mediators, such as cytokines, interleukin
(IL)-1, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α, neutrophils, and fibroblasts are
accumulated in the alveoli sac, which becomes infected. It may lead to hypoxia followed by severe
pulmonary congestion and the death of the patient. There is an urgent need for the treatment of artificial
respiration and ventilation. However, the situation may be the worst for patients suffering
from lung cancer, pulmonary tuberculosis, and acute pneumonia caused by acute respiratory distress
syndrome (ARDS). Re-urgency has been happening in the case of coronavirus disease of
2019 (COVID-19) patients. Therefore, it is needed to protect the lungs with the intake of natural
phytomedicines. In the present review, several selected phyto components having the potential role
in lung injury therapy have been discussed. Regular intake of natural vegetables and fruits bearing
these constituents may save the lungs even in the dangerous attack of SARS-CoV-2 in lung cancer,
pulmonary TB, and pneumatic patients.
Advances in the Pharmacological and Non-pharmacological Management
of Non-motor Symptoms in Parkinson’s Disease: An Update Since 2017
Authors: Wamelen Daniel J. Van , Rukavina Katarina , Podlewska Aleksandra M. , Chaudhuri K. Ray
Published: March 2022

Background:

Non-motor symptoms (NMS) are an important and ubiquitous determinant
of quality of life in Parkinson’s disease (PD). However, robust evidence for their treatment is still a
major unmet need.

Objective:

This study aimed to provide an updated review on advances in pharmacological, nonpharmacological,
and exercise-based interventions for NMS in PD, covering the period since the
publication of the MDS Task Force Recommendations.

Methods:

We performed a literature search to identify pharmacological, non-pharmacological, and
exercise-based interventions for NMS in PD. As there are recent reviews on the subject, we have
only included studies from the 1st of January 2017 to the 1st of December 2021 and limited our
search to randomised and non-randomised (including open-label) clinical trials.

Results:

We discuss new strategies to manage NMS based on data that have become available since
2017, for instance, on the treatment of orthostatic hypotension with droxidopa, several dopaminergic
treatment options for insomnia, and a range of non-pharmacological and exercise-based interventions
for cognitive and neuropsychiatric symptoms, pain, and insomnia and excessive sleepiness.

Conclusion:

Recent evidence suggests that targeted non-pharmacological treatments, as well as
some other NMS management options, may have a significant beneficial effect on the quality of life
and need to be considered in the pathways of treatment of PD.
Clinical and Molecular Heterogeneity of Silver-Russell Syndrome and
Therapeutic Challenges: A Systematic Review
Authors: Khetarpal Preeti , Singh Amit , Pajni Ketan , Panigrahi Inusha
Published: March 2022

Background:

Silver-Russell syndrome (SRS) is a developmental disorder involving ex-treme growth failure, characteristic facial features and underlying genetic heterogeneity. As the clinical heterogeneity of SRS makes diagnosis a challenging task, the worldwide incidence of SRS could vary from 1:30,000 to 1:100,000. Although various chromosomal, genetic, and epigenetic mutations have been linked with SRS, the cause had only been identified in half of the cases.

Material and Methods:

To have a better understanding of the SRS clinical presentation and muta-tion/epimutation responsible for SRS, a systematic review of the literature was carried out using ap-propriate keywords in various scientific databases (PROSPERO protocol registration CRD42021273211). Clinical features of SRS have been compiled and presented corresponding to the specific genetic subtype. An attempt has been made to understand the recurrence risk and the role of model organisms in understanding the molecular mechanisms of SRS pathology, treatment, and management strategies of the affected patients through the analysis of selected literature.

Results:

156 articles were selected to understand the clinical and molecular heterogeneity of SRS. Information about detailed clinical features was available for 228 patients only, and it was observed that body asymmetry and relative macrocephaly were most prevalent in cases with methylation defects of the 11p15 region. In about 38% of cases, methylation defects in ICRs or genomic muta-tions at the 11p15 region have been implicated. Maternal uniparental disomy of chromosome 7 (mUPD7) accounts for about 7% of SRS cases, and rarely, uniparental disomy of other autosomes (11, 14, 16, and 20 chromosomes) has been documented. Mutation in half of the cases is yet to be identified. Studies involving mice as experimental animals have been helpful in understanding the underlying molecular mechanism. As the clinical presentation of the syndrome varies a lot, treat-ment needs to be individualized with multidisciplinary effort.

Conclusion:

SRS is a clinically and genetically heterogeneous disorder, with most of the cases be-ing implicated with a mutation in the 11p15 region and maternal disomy of chromosome 7. Recur-rence risk varies according to the molecular subtype. Studies with mice as a model organism have been useful in understanding the underlying molecular mechanism leading to the characteristic clin-ical presentation of the syndrome. Management strategies often need to be individualized due to varied clinical presentations.
Diabetic Ketoacidosis (DKA), a Leading Risk Factor for Mucormycosis
(Black Fungus), during the Era of Coronavirus Disease-2019 (COVID-19):
An Overview
Authors: Rais Nadeem , Ahmad Rizwan , Ved Akash , Parveen Kehkashan , Bari Darakhshan Gazala , Prakash Om
Published: March 2022

Introduction:

Diabetes mellitus (DM) and steroid medication, coincided with coronavirus
disease 2019 (COVID-19), results in a weakened immune system, allowing some commonly
found pathogens to become more harmful. Mucormycosis (black fungus) is a type of opportunistic
infection caused by fungi belonging to the Mucorales family. DM is the most prominent risk factor
for mucormycosis. Excessive blood sugar and decreased insulin levels lead to diabetic ketoacidosis
(DKA), a devastating complication of DM that can be fatal if left untreated.

Methods:

Diabetic ketoacidosis is more common in type 1 diabetic patients, although it can also be
fall in type 2 diabetic patients. DKA occurs when the body lacks enough insulin to allow blood
sugar to enter the cells and is used for energy. Instead, the liver breaks down fat for fuel-producing
chemicals known as ketones.

Results:

When too many ketones are created too quickly, they can reach dangerously high levels in
the body. Mucormycosis is a rare but serious infectious disease that requires medication or surgical
removal.

Conclusion:

The confluence of diabetes and COVID-19 makes managing mucormycosis a serious
and dead issue. Although the effectiveness of prophylactic antifungal therapy has yet to be demonstrated,
hyperglycemia control appears to be the most important step in managing mucormycosis in
DKA patients.
ZY12201: A Potent TGR5 Agonist: Identification of a Novel Pan CYP450
Inhibitor Tool Compound for In-Vitro Assessment
Authors: Giri Poonam , Gupta Lakshmikant , Rathod Anil , Joshi Vipul , Giri Shyamkumar , Patel Nirmal , Agarwal Sameer , R Jain Mukul
Published: March 2022

Background:

The key objective was to evaluate the CYP inhibition potential of ZY12201 for an opportunity
to use it as a tool compound for pan CYP inhibition activities.

Objective:

The key objective was to evaluate the CYP inhibition potential of ZY12201 for an opportunity
to use it as a tool compound for pan CYP inhibition activities.

Method:

In-vitro Drug-Metabolizing Enzyme (DME) inhibition potential of ZY12201 was evaluated
against major CYP isoforms (1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4/5), Aldehyde
Oxidase (AO), Monoamine Oxidase (MAO), and Flavin-containing Monooxygenase (FMO) in
human liver cytosol/mitochondrial preparation/microsomes using probe substrates and Liquid
Chromatography with tandem Mass Spectrometry (LC-MS-MS) method).

Results:

It was found that the study conducted on ZY12201 at 100 μM ZY12201 showed a reduction
in the metabolism of vanillin (AO probe substrate), tryptamine (MAO probe substrate), and
benzydamine (FMO probe substrate) by 49.2%, 14.7%, and 34.9%, respectively. ZY12201 Ki values
were 0.38, 0.25, 0.07, 0.01, 0.06, 0.02, 7.13, 0.03 and 0.003 μM for CYP1A2, CYP2B6,
CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4/5 (substrate: testosterone) and
CYP3A4/5 (substrate: midazolam), respectively. Time-dependant CYP inhibition potential of
ZY12201 was assessed against CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6,
CYP2E1, and CYP3A4/5, and no apparent IC50 shift was observed.

Conclusions:

ZY12201, at 100 μM concentration, showed low inhibition potential of AO, MAO,
and FMO. ZY12201 was found as a potent inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and
3A4/5 while moderately inhibiting CYP2E1. Inhibition of CYP1A2, CYP2B6, CYP2C19, and
CYP2E1 by ZY12201 was competitive, while the inhibition of CYP2C8, CYP2C9, CYP2D6, and
CYP3A4/5 was of mixed-mode. ZY12201 is a non-time-dependent inhibitor of CYP1A2,
CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5.
In summary, the reported Ki values unequivocally support that ZY12201 has a high potential to
inhibit all major CYP isoforms. ZY12201 can be effectively used as a tool compound for in-vitro
evaluation of CYP-based metabolic contribution to total drug clearance in the lead optimization
stage of drug discovery research.