bluuebunny/crossref_metadata_2025 huggingface dataset:
Leveraging social media to increase lung cancer screening awareness, knowledge and uptake among high-risk populations (The INSPIRE-Lung Study): Study protocol of design and methods of a community-based randomized controlled trial
Authors: Carter-Bawa Lisa , Banerjee Smita C , Ostroff Jamie S , Kale Minal S , King Jennifer C , Leopold Katherine T , Monahan Patrick O , Slaven James E , Wiener Renda Soylemez , Valenzona Francis , Rawl Susan M , Comer Robert Skipworth
Published: May 2023

Background.Lung cancer is the leading cause of cancer death for both men and women in the United States. The National Lung Screening Trial (NLST) demonstrated that low-dose computed tomography (LDCT) screening can reduce lung cancer mortality among high-risk individuals, but uptake of lung screening remains low. Social media platforms have the potential to reach a large number of people, including those who are at high risk for lung cancer but who may not be aware of or have access to lung screening.Methods.This paper discusses the protocol for a randomized controlled trial (RCT) that leverages FBTA to reach screening-eligible individuals in the community at large and intervene with a public-facing, tailored health communication intervention (LungTalk)to increase awareness of, and knowledge about, lung screening.Discussion.This study will provide important information to inform the ability to refine implementation processes for national population efforts to scale a public-facing health communication focused intervention using social media to increase screening uptake of appropriate, high-risk individuals.Trial Registration: The trial is registered at clinicaltrials.gov (#NCT05824273).
Functional annotation of genes associated with colonization and establishment of endophytes in Emilia sonchifolia (LINN.) DC
Authors: Urumbil Sithara K , NAIR ANILKUMAR MADHAVAN
Published: May 2023

Purpose The entry of rhizosheric bacteria into a plant requires efficient genomic machinery that favours its internalization into the host tissues. We hypothesize that the screening of microbial colonization genes can give an insight into the selection process where some of the soil microbes transform into endophytes in their respective host plants.Methods Total DNA was isolated from Emilia sonchifolia, PCR amplified and sequenced using Illumina Miseq method. Then metagenome assembly and gene prediction were done followed by gene functional annotation using Nr, KEGG, eggnog and CAZy databases.Results Gene functional annotations revealed the presence of genes coding for proteins involved in chemotactic movements such as cheW, cheY, che and CheR, flagellar and pilin assembly genes, genes associated with biofilm formation viz. Wza, Wzb, Wzc and WcaM, quorum sensing genes, genes associated with osmoprotectants, host defense etc.Conclusions The establishment of endophytes is a complex process and still many lacunae exist in our understanding of the process of internalization and formation of endophytes. This study confirms the presence of genes associated with colonization, internalization and penetration of endophytes in the medicinally important plant Emilia sonchifolia and thus adds to our current knowledge in plant-microbe interaction.
A rare case of Cushing’s syndrome presenting with dilated cardiomyopathy
Authors: Erdogan Beril Turan , Helvacı Burçak Cavnar , Houssein Mehdi , Postacı Nadide Aysun , Kafes Habibe , Seyrek Fatma Neslihan Çuhacı , Aydın Cevdet , Ersoy Reyhan , Topaloğlu Oya , Çakır Bekir
Published: May 2023

Introduction:
Cushing's syndrome (CS) is characterized by excessive cortisol production. Notably, 50% of deaths were due to cardiovascular disease. CS may associate with cardiomyopathies (CMPs), whose pathophysiology is poorly understood. We describe a patient presenting with acute heart failure and recently diagnosed with CMP who was found to have hypercortisolism secondary to an adrenal adenoma.
Case:
A 31-year-old male patient was admitted to the cardiology department due to dyspnea. He had a weight gain of 25 in the last year. His blood pressure was 135/85 mmHg, and his pulse rate was 102bpm. He had central obesity (body mass index: 31 kg/m2), buffalo hump, and abdominal purple-blue wide striae. Transthoracic echocardiography revealed global hypokinesia [left ventricle end-diastolic diameter of 6 cm/m2 (normal range < 3.2 cm/m2) on M-mode], and 20%of LVEF (standard: 50–70%). Laboratory evaluation revealed increased plasma cortisol levels with an absence of circadian rhythm. Serum cortisol levels were not suppressed after the overnight 1 mg and two-day low-dose dexamethasone suppression test (LDDST). The hormonal evaluation indicated ACTH-independent CS (Table-1). Magnetic-resonance imaging of the adrenal gland revealed a 37x28mm adenoma in the lateral limb of the left adrenal gland. The patient was diagnosed with CS. Metyrapone was used to reduce cortisol levels before the surgery. The plasma cortisol level decreased to 14.8 µg/dL on the 20th day of metyrapone treatment. Although the ejection fraction of the left ventricle was still 40% on echocardiography (Table-2), improvement of heart failure symptoms was achieved (New York Heart Association (NYHA) class II). After reducing plasma cortisol levels and improving the EF, he underwent a successful left adrenalectomy procedure. Clinical and laboratory findings improved significantly soon after surgery. The pathology result was reported as diffuse nodular hyperplasia. The patient's LVEF was 50% at the 6th month follow-up and > 60% at the 1st year follow-up.
Conclusion:
CS CMP is a reversible entity induced by hypercortisolism. It is characterized by cell hypertrophy, myofibrillolysis, and myocardial fibrosis that revert after adrenalectomy. In addition, preoperative anesthesia risk may increase due to low LVEF because of the CMP. Therefore, patients may need to be treated preoperatively with rapid-acting adrenolytic drugs.
Complex spatiotemporal dynamics in a network of locally and magnetically coupled VDPCL oscillators
Authors: TEGNITSAP Joakim Vianney NGAMSA , KENGNE Romanic , NKENGFACK Laurent Chanel DJOUFACK , FOTSIN Hilaire Bertrand
Published: May 2023

Nowadays, we are witnessing a dramatic advance in wireless technology-based magnetic induction. It is used both for wireless power transfer and data transfer between systems. In addition, it is widely shown that a network of coupled identical oscillators exhibits complex collective behavior characterized by the coexistence of coherent and incoherent domains and termed as chimera state. In this paper, we consider a network of (N≥10) locally and magnetically coupled Van der Pol oscillators coupled to a linear circuit (VDPCL oscillators). We then investigate the different arrangements of their interactions in terms of the magnetic coupling coefficients, taken as the bifurcation parameters. Statistical measure namely the strength of incoherence is used to classify the synchronized states in the network. Another algorithm described in the text is used for the classification and is consistent with the strength of incoherence. Numerical simulation reveals that the emerging spatiotemporal behaviors depend on the choice of initial conditions revealing the presence of multistability in the network. This network configuration also reveals a rich repertoire of spatiotemporal dynamics such as coherence/global synchronization, decoherence, chimera state, cluster synchronization, and solitary states as the magnetic coupling coefficients vary. Some other interesting behaviors such as traveling clustered wave, double and multicluster chimera state, and clustered solitary state for a specific set of initial conditions are also obtained. Furthermore, Pspice-based simulations carried out for a network of (N=10) oscillators are consistent with the numerical simulations based on the mathematical model.
Synthesis, characterization and non-isothermal degradation kinetics of rosebengal end capped Poly(aniline)/Cr2O3 nanocomposite
Authors: Ramasamy Anbarasan , Mary M. Kenet Nancy , Jancirani A. , Baskaran R.
Published: May 2023

Solution polymerization of aniline was carried out in the presence of peroxydisulphate as a radical initiator under N2atmosphere at 0-5oC for 2 hours both in the presence and absence of Cr2O3(bulk)material under vigorous stirring condition. During the polymerization reaction the rosebengal (RB) dye was added as an end capping agent. The above synthesized polymers were characterized by FT-IR, UV-visible, fluorescence emission, XPS, XRD, DSC, TGA, SEM, HR-TEM, viscosity and conductivity measurements. The added Cr2O3(bulk)controlled the structure of Poly(aniline) (PANI) and the same can be confirmed by FT-IR spectroscopy. The Tgof Cr2O3medicated poly(aniline) showed somewhat higher value than the pristine PANI. The XPS showed the presence of Cr3d2p3/2and Cr3d2p1/2peaks and this confirmed the nano-sized crystalline Cr2O3. Further, its thermal degradation was studied by non-isothermal degradation kinetics and their thermodynamic parameters were determined. The experimental data was compared with the available literature data.
Mesh-Container Plasty in advanced painful osteolytic vertebral metastases with posterior wall defect：a retrospective observational study
Authors: Liu Qingshan , Li Dingding , He Yuanliang , Lei Xi , Yan Jun , Feng Wei , He Chengchui , Huang Xuemei , Cao Dan , Dong Yingchun
Published: May 2023

Background：
Percutaneous vertebroplasty for deficient posterior wall of metastatic vertebrae lead to high rate of bone cement leakage. In order to improve the safety, MCP, a new technique improved based on PVP, has been developed to control the dispersion of bone cement.
Objective:
To evaluate the efficacy and safety of Mesh-Container Plasty (MCP) in patients suffering advanced vertebral metastases with deficient posterior wall.
Patients and methods:
111 patients were retrospectively included from January 2014 to January 2018 in our hospital. These patients were divided into two groups, group MCP (n=51) and group PVP (n=60). According to the percentage of the area of posterior wall defect as the total area of posterior wall, the patients of both groups were originally classified into four grades, grade I≤25%, grade II 26%-50%, grade III 51%-75%, grade IV 76%-100%. Visual analog scale (VAS) and Oswestry disability index (ODI) were applied to compare the efficacy before and after MCP and PVP. Minor and major complications were systematically recorded to measure the safety.
Results：
Both groups experienced significant pain relief and improvement of motor function after MCP and PVP. Pre-op and post-op VAS and ODI at any time point during follow-up did not present significant difference between MCP and PVP (P > 0.05). In MCP, 13 cases presented bone cement leakage, with the leakage rate of 25.49%. None of the patients developed any clinical or neurological symptoms. In PVP, 50% of the patients occurred bone cement leakage. Six patients developed neurological symptoms. major complications between two groups presented significant difference for bone cement leakage (P=0.03).
Conclusion:
In conclusion, MCP is able to significantly relieve pain and improve the safety in treating vertebral metastases with deficient posterior wall. It provides a better option for spinal surgeon to treat vertebral metastases with posterior wall deficiency.
Features & Data Graphs of Hospitalisation Fever: A Case in Teaching Medical Centres
Authors: H Frank (D.C.)
Published: May 2023

I. BACKGROUND
The understanding of hospitalization fever remains limited. Improving care could be facilitated by considering specific diseases associated with fevers, as indicated by ICD9 codes in admission or discharge notes.
II. METHODS
We conducted an analysis using data from Taipei Medical University Hospital, examining 59,772 inpatient admissions and 425,488 nights of stay annually between 2007 and 2009. Decision tree and rule induction techniques were employed to characterize fever-related diseases during hospitalization. Association rules were generated to suggest and validate comorbidities beyond those related to fever.
III. CONCLUSIONS
Throughout the three-year period, fever consistently ranked as the most frequent ICD9 code in inpatient health records, including admission and discharge notes, accounting for over 25% of the top six most common codes. Our study illustrated the diseases associated with fever and their comorbidities. Notably, 81.193% of fever-related ICD9 codes occurred fewer than 14 times, and the association rules for fever-related comorbidities improved care with a 48.077% coverage rate through appropriate CPOE implementation.
A DFT-Based Investigation of the properties of gold nanoclusters up to Au20
Authors: Kargar Ali , Mohammadnejad Sima
Published: May 2023

The structures and stabilities of gold clusters with up to 20 atoms have been studied by Density Functional Theory (DFT) and compared in two vacuum and COSMO environment here for the first time. The structure optimizations and frequency analysis are performed with the Generalized Gradient Approximation (GGA) BLYP (Becke, 1988; Lee et al., 1988) functional in Dmol3combined with the all-electron relativistic core treatment and corresponding Double Numerical plus Polarization (DNP) basis set. The transition point from two-dimensional to three-dimensional geometry for gold clusters occurs at Au17in both the vacuum and COSMO environment. The structural, energetic, and electronic properties of the small gold clusters strongly depend on sizes and structures, which are in good agreement with other theoretical and experimental calculations. It was also found that the effect of relativistic properties has a great influence on the properties of gold clusters. The even-odd oscillation (saw-tooth patterns) observed in the different properties of the clusters predicts the stability of the clusters and their electronic properties. The result shows that the clusters with even numbers of atoms were more stable than the neighboring clusters with odd numbers of atoms due to their closed-shell orbital structure. Also, the properties of gold nanoclusters in COSMO seem to be different from the vacuum environment.
Effect of neoadjuvant chemoradiation therapy is independent of intratumoral vascularization in resectable pancreatic cancer
Authors: Yasue Tomomi , Ashida Reiko , Takada Ryoji , Ikezawa Kenji , Ohkawa Kazuyoshi , Nagata Shigenori , Teshima Teruki , Akita Hirofumi , Takahashi Hidenori , Doki Yuichiro , Eguchi Hidetoshi
Published: May 2023

Background Neoadjuvant chemoradiation therapy (NACRT) is a multidisciplinary treatment for pancreatic cancer (PC) in which the effect of anticancer drugs depends on intratumoral blood flow. Most PCs are hypovascular; however, the additional effects of radiation therapy on drug efficacy are unclear. We investigated the relationship between PC vascularity and the therapeutic effect of NACRT using contrast-enhanced harmonic EUS (CH-EUS).Methods Patients with resectable PC who underwent CH-EUS followed by NACRT were analyzed retrospectively. The CH-EUS enhancement pattern was evaluated in the vascular and perfusion phases, and classified according to vascularity: Group A, hypovascular in both phases; Group B, isovascular and hypovascular in the vascular and perfusion phases, respectively; Group C, isovascular in both phases. The relationship between CH-EUS vascular pattern and the histological effect of NACRT, recurrence-free survival (RFS), and overall survival (OS) were assessed.Results Of 48 enrolled patients, 31, 11, and 6 were classified into Groups A, B, and C, respectively. There was no significant difference in histopathological differentiation, efficacy of NACRT, median RFS or OS among the groups.Conclusions There was no significant difference in the histopathological efficacy of NACRT for resectable PC in terms of the enhancement pattern of CH-EUS. NACRT may provide additional therapeutic effect regardless of blood flow.
Modelling nicotine pharmacokinetic profile for e-cigarette using real time monitoring of consumer’s physiological measurements and mouth level exposure
Authors: Prasad Krishna , Griffiths Allen , Agrawal Kavya , McEwan Michael , Macci Flavio , Ghisoni Marco , Stopher Matthew , Napleton Matthew , Strickland Joel , Keating David , Whitehead Thomas , Conduit Gareth , Murray Stacey , Edward Lauren
Published: May 2023

Pharmacokinetic (PK) studies can provide essential information on abuse liability of nicotine and tobacco products but are intrusive and must be conducted in a clinical environment. The objective of the study was to explore whether changes in plasma nicotine levels following use of an e-cigarette can be predicted from real time monitoring of physiological parameters and mouth level exposure (MLE) to nicotine before, during, and after e-cigarette vaping, using wearable devices. Such an approach would allow an -effective pre-screening process, reducing the number of clinical studies, reducing the number of products to be tested and the number of blood draws required in a clinical PK study Establishing such a prediction model might facilitate the longitudinal collection of data on product use and nicotine expression among consumers using nicotine products in their normal environments, thereby reducing the need for intrusive clinical studies while generating PK data related to product use in the real world.
A machine learning model was developed to predict changes in plasma nicotine levels following the use of an e-cigarette; from real time monitoring of physiological parameters and MLE to nicotine before, during, and after e-cigarette vaping. This preliminary study identified key parameters, such as heart rate (HR), heart rate variability (HRV), and physiological stress (PS) that may act as a predictors for an individual’s plasma nicotine response (PK curve). Relative to baseline measurements (per participant), HR showed a significant increase for nicotine containing e-liquids and was consistent across sessions (intraparticipant). Imputing missing values and training the model on all data resulted in 57% improvement from the original ’learning’ data and achieved a median validation R2 of 0.70.
Diagnostic value of transvaginal color Doppler ultrasonography findings in post treatment follow up of cesarean scar pregnancy
Authors: Sodabi Maryam , Karbasi Mahsa , Eghbali Elham , Abbasalizadeh Fatemeh , Razmifard Farzad , Azari Mojtaba , Ahangar-sirous Ramin , Shahestan Alireza Omara , Alihosseini Samin
Published: May 2023

Aim: Cesarean scar pregnancy can cause life-threatening complications for pregnant women, so early diagnosis and treatment is crucial for prevention of maternal mortality. Transvaginal color Doppler ultrasonography besides serum β-hCG level follow-up can be a noninvasive and proper method for post-treatment follow-up of a cesarean scar pregnancy. In the present study, we investigated the Doppler resistance index changes in cesarean scar pregnancies after medical management together with sac diameter and serum β-hCG level measurement.
Methods: 28 patients with cesarean scar pregnancy and a history of previous cesarean delivery, gestational age of less than 9 completed weeks at ultrasonography, decision to medical management by gynecologist and with having a β-hCG level before treatment were enrolled and initially examined by ultrasound and Doppler studies. The resistance index of the closest myometrial artery to cesarean scar pregnancy mass and its diameter were measured. After 72 hours, 1 week and 2 weeks after medical therapy, mentioned variables were measured again and were compared to the values of the pretreatment time point.
Results: Resistance index values were significantly higher in all of the follow-up time points compared with the pretreatment time points, while serum β-hCG levels were significantly lower. Moreover, sac diameter values were increased 72 hours post-treatment and then declined.
Conclusions: Serial Doppler ultrasound examinations can be a useful method to evaluate the success or failure of medical management of cesarean scar pregnancies as the increase in resistance index values occur rapidly after medical treatment and correlate well with serum β-hCG levels.
Evaluation of the treatment of distal radial volar fracture by different methods sparing the pronator quadratus
Authors: Huang Xiaoxia , Liu Tao , Xue Zhaoxi , Wu Boyu , Kong Weiqi , Ye Kai , Jia Qiyu , Teng Yong , Zhao Yan
Published: May 2023

Background The conventional volar approach requires the release of the pronator quadratus (PQ) muscle in the treatment of distal radius fractures. However, releasing PQ muscle could cause loss of function and a host of complications.Aim This study compared the outcomes of different methods of sparing the PQ muscle combined with volar plate in the treatment of distal radius fractures.Methods A total of 68 patients with distal radius fractures were enrolled with either the brachioradialis (BR) splitting approach (Group A,33 people) or through the tunnel behind the PQ muscle approach (Group B,35 people). Postoperative internal fixation, fracture healing and postoperative complications were observed in the two groups. The visual analog scale (VAS) of postoperative wrist pain was compared between the two groups. The Dienst joint scale was used to evaluate the wrist function of patients, and imaging indexes were used to evaluate the surgical efficacy.Results A total of 68 patients with distal radius fractures were followed up for more than 1 year after surgery. All fractures obtained good union, with no vascular injury, nerve injury, or wound infection. There was no significant difference in the baseline characteristics of both groups. Outcomes at 3 days,1 month,and 3 months all showed no significant differences in postoperative imaging indexes between the two groups. There were significant differences in the mean operative time between the two groups. Nevertheless, no significant differences were shown in mean operative blood loss and mean bone union time between the two groups. There was no significant difference in the results of complications between the two groups. No significant differences in limb function scores, VAS scores and the mean range of motion existed the two groups at the 12-month postoperative follow-up. However, outcomes assessed at 1 week, 1 month, and 3 months after surgery demonstrated significant differences in the VAS scores and the mean range of motion between the two groups.Conclusion Our results demonstrated that these two different surgical approaches were effective ways to reserve PQ and had good clinical outcomes. Placing the plate under the quadratus muscle could reduce early postoperative pain, promote early activity, and returned to normal life. The BR splitting approach was more advantageous in intraoperative fracture exposure and could shorten the operative time. However, some defects also existed. Therefore, surgeons should be aware of their individual characteristics and chose patients carefully.
A novel higher-order numerical method for parabolic integro-fractional differential equations based on wavelets and $L2$-$1_\sigma$ scheme
Authors: Santra Sudarshan , Behera Ratikanta
Published: May 2023

This paper aims to construct an efficient and highly accurate numerical method to solve a class of parabolic integro-fractional differential equations, which is based on wavelets and L2-1σ scheme; specifically, the Haar wavelet decomposition is used for grid adaptation and efficient computations, while the high order L2-1σ scheme is taken into account to discretize the time-fractional operator. In particular, second-order discretizations are used to approximate the spatial derivatives to solve the one-dimensional problem. In contrast, a repeated quadrature rule based on trapezoidal approximation is employed to discretize the integral operator. On the other hand, we use the semi-discretization of the proposed two-dimensional model based on the L2-1σ scheme for the fractional operator and composite trapezoidal approximation for the integral part. Then, the spatial derivatives are approximated by using the two-dimensional Haar wavelet. Here, we investigated theoretically and verified numerically the behavior of the proposed higher-order numerical method. In particular, the stability and convergence analysis of the proposed higher-order method has been studied. The obtained results are compared with some existing techniques through several graphs and tables, and it is shown that the proposed higher-order methods have better accuracy and produce less error compared with the L1 scheme.
MSC Classification: 45K05 , 45D05 , 26A33 , 65M06
Modeling the effects of climate change on the habitat suitability of Mediterranean gorgonians
Authors: Bellin Nicolò , Rossi Valeria
Published: May 2023

Multiple stressors including global warming increasingly threaten the distribution and abundance of gorgonian forests. We built species distribution models (SDM) combined with machine learning algorithms, to compare the ecological niche of three Mediterranean gorgonian species (Paramuricea clavata,Eunicella cavoliniiandEunicella singularis)and distribution response to climate change under the worst IPCC scenario RCP8.5. Three Machine Learning models, XGBoost, Random Forest and the K-nearest neighbour, 23 physico-chemical and 4 geophysical environmental variables were used to obtain the potential habitat suitability and future projections (2040–2050) of their distribution in the Mediterranean Sea. The global sensitivity and uncertainty analysis was used to identify the most important environmental variables shaping the habitat suitability of the species and to disentangle the interaction terms among different environmental variables. For all species, bathymetry was the main variable influencing habitat suitability, with higher interactions with silicate, salinity and concavity. In future climatic conditions,P. clavatawas expected to shift its habitat suitability from lower to higher latitudes, mainly in the Adriatic Sea. For bothE. cavoliniiandE. singularis, a general habitat reduction was predicted. In particular,E. cavoliniiwas expected to reduce the occupancy area of 49% suggesting that the sensitivity of the symbiotic algae (zooxanthellae) may not be the main responsible of the corresponding susceptibility of the holobiont to thermal stresses and climate change.
Hip and knee replacements performed in Colombia between 2012 and 2021, burden and tendencies. A perspective from SISPRO
Authors: Useche Luis Fernando , Gaitan-Lee Hernando , Mejía-Grueso Alejandro , Monroy-Rivera Mateo
Published: May 2023

The Colombian Ministry of Health and Social Protection (MHSP) gathers timely, sufficient, and standardized information for decision-making in the health sector through the Integrated Social Protection Information System (SISPRO). This system is made up of databases and information systems on supply and demand of health services, quality, insurance, financing, social promotion.(1) This project seeks to evaluate the information contained in this database, referring to the number of primary hip and knee joint replacements that were performed in Colombia, in the period 2012–2021 and describe their distribution in terms of age, sex, insurance system, and geographical location. There is currently no information reported nor analyzed regarding this topic. Through a pivot table, fed by the SISPRO cubos3 database; crosses of variables were carried out to obtain information on the number of partial or total joint replacements executed in Colombian territory; describing distributions by age in decades, sex, insurance regime and geographical distribution by Departments. The historical number of replacements in Colombia between 2009 to 2014 is described. This allows us to establish behavior in the last decade. The effect of the COVID-19 pandemic is also described. In Colombia, an average of 5698 (sd.851) hip replacements and 5005 (sd.1156) knee replacements were performed each year during the last decade (2012–2021). An increasing trend in hip and knee replacements of 5% per year and 10.8% annual total, was observed. The trend in 2020 was affected, as expected by COVID-19 pandemic. This trend was highly affected in knee replacements, with a 32% decrease compared to 2019, whilst hip replacements only decreased 9%. In 2021, the downward trend persisted compared to the previous year, with a 16% decrease in knee replacements and a 6% decrease in hip replacements. Similarly, hip and knee replacements predominated in women, 65% and 71% respectively. Most of these procedures were done in females over the age of 50. The state insurance system sponsors 90% of the procedures, the subsidized regime predominates over the contributory one. Geographically, the largest number of replacements are made in Bogota (Cundinamarca), Medellin (Antioquia) and Cali (Valle del Cauca). There was an important number of hip replacements done in Pasto (Nariño) and Bucaramanga (Santander). On the other hand, it was significantly important to state that in Bucaramanga (Santander) and Barranquilla (Atlantico) there was a high volume of knee replacements done per year. The reliability of this registry lies in the multiple official sources of the MHSP and in the national coverage of the General Social Security System in Health (GSSSH), which according to official data from the MHSP, is above 90% throughout the reporting period.
A Fourier descriptor and PSCS-RBF fusion method for pumping machine fault diagnosis
Authors: Bowen Li , Raja S Selvakumar , Jiajun Li , Zejun Yao , Wenguang Song , Haoyuan Li , Changtao Lan , Mawien Kon
Published: May 2023

For the current oilfield pumping machine fault diagnosis, there are time-consuming and inefficient problems, and at the same time high requirements for hardware resources and no universality, this study proposes a pumping machine fault diagnosis method based on improved Fourier descriptor combined with dynamic adaptive cuckoo search (PS cuckoo search, PSCS) to optimize RBF neural network. Firstly, the starting point position of the contour of the power diagram is determined by the minimum inertia axis, and the Fourier transform is performed to achieve the best matching between contours, and the effect of starting point irrelevance. Then feature extraction is performed by combining shape invariant moments as the input layer information of RBF neural network. Then dynamic discovery probability and adaptive step size are introduced to make the cuckoo search easier to retain the better solution, and the step size can be automatically adjusted according to the convergence rate of the objective function to maintain a balanced state of efficiency and accuracy in different search stages. Finally, the RBF neural network is optimized by the improved cuckoo search to obtain the optimal relevant parameters such as the width and weights of RBF, and the PSCS-RBF fault diagnosis model is established. The model is applied to the diagnosis of different fault types of pumping machines and is compared and analyzed with a variety of current mainstream models. The average detection accuracy of the PSCS-RBF fault diagnosis method proposed in the article reaches 96.3%, and the measured results have high accuracy and short time, which verifies the practical value and advantages of the method.
The effects of warm compress therapy on the stability of the tear film in dogs
Authors: Kim Jury , Ji Dong-beom , Jung Sun-jun , Seo Dae-yun , Kim Min-Su
Published: May 2023

Background
Meibomian gland dysfunction (MGD) is defined as functional abnormalities of the meibomian gland and is commonly caused by meibomian gland hyposecretion or obstruction. This results in an improper tear lipid layer which increases the tear evaporation and makes the tear film instability, leading to qualitative dry eye disease. In humans, a mainstay of the management of MGD is eyelid warming. This improves meibum secretion by melting pathologically altered meibomian lipids. While nearly ubiquitous in human medicine, there are no reports of the effects of warming therapy on the eyelids in veterinary medicine. This study is to evaluate the effect of warm compress therapy on canine tear film quality parameters. Eight systemically healthy male Beagle dogs with normal ophthalmic examinations (16 eyes) were used for this study. The temperature of the outer upper eyelid, the upper palpebral conjunctiva, and the central cornea were evaluated with an infrared thermometer, and tear film quality was assessed with meibometry and evaluation of the tear film break up time (TFBUT). These parameters were measured before and immediately following the application of the warm compress. A paired t-test was used to compare the data before and after warm compress treatment. For statistical analysis, SPSS was used and a P value < 0.05 was considered significant.
Results
All parameters increased after warm compression. The temperature of the outer and upper palpebral eyelid, and the central cornea increased significantly, from 34.0±1.0°C to 35.3±1.0°C, from 34.2±0.8°C to 35.5±0.8°C, from 34.2±0.8°C to 35.0±0.7°C, respectively. In meibometry, the mean±SD meibomian level at the baseline was 109.0±44.1 MU, whereas after warm compress therapy, it significantly increased to 155.9±71.3MU (p<0.05). TFBUT increased from 8.9±3.0 to 10.5±2.3 seconds.
Conclusions
Application of warm compress to the external eyelids has a significant effects of tear film quality parameters and may be useful to improve tear film stability in dogs.
Postnatal Kangaroo Mother Care practice at home in Low-birth-weight babies in rural coal mines area West Bokaro Jharkhand, India: A Community-Based Prospective Observational Study
Authors: Prasad Tulsi , Roy Ashish
Published: May 2023

Background Low birth weight (LBW) newborns especially those < 2000 gms are more prone to hypothermia due to which other physiological parameters gets deteriorated in 1st week of life. The objective of this observational study was to continue Kangaroo Mother Care practice at home and ascertain whether KMC was effective in improving the vital parameters of LBW babies when given at home in a rural coal mines area, in Jharkhand, India.Methods This study was a community-based prospective observational study, done over three years from November 2019 to November 2022. This study included 156 pairs of both mothers and LBW babies (weight 1500 to < 2000 gm). After discharge from the hospital on day 3, KMC was continued at home on day 4, day 5, and day 6. Data of four physiological parameters, temperature, oxygen saturation, respiratory rate, and heart rate, were collected before and after KMC and analyzed.Results Among 400 newborns, 156 LBW babies (39.0%) who were given KMC at home, showed similar but statistically significant improvement of vital parameters, especially in temperature and oxygen saturation(p < 0.0001) compared to the same babies 156(39.0%) given KMC in the hospital (p < 0.001).Conclusion Kangaroo Mother Care, which was continued at home, has a significant role in the Improvement of vital parameters, especially concerning temperature and oxygen saturation. If the babies in the weight range of 1500 to < 2000 gm are healthy, well-breast fed, and have no other risk factors can be discharged early, and managed at home by delivering supportive care, nursing care along with Kangaroo Mother Care with continuous follow-up.
Vibration Control of High-rise Building Via Optimal TMD for Earthquake by Black Window with Elman Model
Authors: Vanshaj Kumar , K Shukla A , Shukla Mukesh , Mishra Abhishek
Published: May 2023

Tuned Mass Dampers (TMDs) are a useful control gadget to diminish undesired vibrations of tall buildings and gigantic reach ranges against equal burdens like breezes and earthquakes. The better limits for TMD are to reduce the earthquake vibrations of tall buildings; including Soil-Plan Interaction (SSI) influences. The chief mark of this survey is to upgrade the limits of TMD presented to earthquakes and consider the effects of SSI. This study proposes the multi-objective Black Window Optimization (BWO) with Elman Neural Network (ENN) computation is brought on to find the optimal limits of TMD. Considering this procedure redesign the TMD including mass, stiffness, and damping to get the most noteworthy accelerations and displacement of 40 story building model. This is accomplished through restricted part diversions in which soil-structure interaction is depicted by extraordinary impedance capacities, to have computationally capable models to focus on the properties of the soil-structure system. The results are conveyed to the extent that non-layered execution twists of the TMD addressing soil-structure interaction and this proposed procedure is the execution of the MATLAB stage. From the execution results, this proposed BWO-Elman model differentiated and customary methodology, the most outrageous TMD limits are better, likewise, this study assists the researchers with a bettering understanding of earthquake vibrations, and leads the fashioners to achieve the superior TMD for tall designs.
Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region
Authors: Bazan Hernan , Bhattacharjee Surjyadipta , Reid Madigan , Jun Bokkyoo , Polk Connor , Strain Madeleine , Pierre Linsey St , Desai Neehar , Daly Patrick , Cucinello-Ragland Jessica , Edwards Scott , Alvarez-Builla Julio , Cai James , Bazan Nicolas
Published: May 2023

The safe and effective management of pain is a critical healthcare and societal need. The potential for misuse and addiction associated with opioids, nephrotoxicity, and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) use, as well as acute liver injury from paracetamol (ApAP) overdose, are unresolved challenges. To address them, we developed a non-opioid and non-hepatotoxic small molecule, SRP-001. Compared to ApAP, SRP-001 is not hepatotoxic as it does not produce N-acetyl-p-benzoquinone-imine (NAPQI) and maintains hepatic tight junction integrity at high doses. SRP-001 has comparable analgesia in pain models, including the complete Freund’s adjuvant (CFA) inflammatory von Frey. Both induce analgesia via N-arachidonoylphenolamine (AM404) formation in the midbrain periaqueductal grey (PAG) nociception area, with SRP-001 generating higher amounts of AM404 than ApAP. Single-cell transcriptomics of PAG uncovered that SRP-001 and ApAP also share modulation of pain-related gene expression and cell signaling pathways, including the endocannabinoid, mechanical nociception, and fatty acid amide hydrolase (FAAH) pathways. Both regulate the expression of key genes encoding FAAH, 2-AG, CNR1, CNR2, TRPV4, and voltage-gated Ca2+ channel. Interim Phase 1 trial results demonstrate SRP-001’s safety, tolerability, and favorable pharmacokinetics (NCT05484414). Given its non-hepatotoxicity and clinically validated analgesic mechanisms, SRP-001 offers a promising alternative to ApAP, NSAIDs, and opioids for safer pain treatment.
Analysis of the intention to use loan facilities from formal financial institutions for large chili farmers through the theory of planned behavior approach
Authors: Widaninggar Nanda , Firdaus Muhammad , Suherman  , Wahyudi Farid , Sauqi Ahmad
Published: May 2023

This study analyzes and examines the factors influencing the intention to use loan facilities from formal financial institutions. This study was carried out quantitatively using the Structural Equation Modeling (SEM) method with the population of large chili farmers in 19 districts in Jember Regency as the region with the best large chili productivity in Indonesia. The results obtained from 116 respondents indicate that the construct of situational temptation does not affect subjective norms. In addition, formal financial institution financing positively affects attitudes toward behavior and subjective norm on intention to use loan facilities, but not on the perceived behavior. Meanwhile, the intention was positively influenced by attitude, subjective norm, and perceived behavior control. The factor with the most significant effect on the intention is perceived behavior control (t-statistics = 4.940). This shows that control of perceived behavior towards intention to use loan facilities from formal financial institutions has the most significant influence among other variables. Acknowledgment The authors would like to thank the Directorate of Research, Technology, and Community Service from the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia, which provided research grants, namely Higher Education Excellence Basic Research (Penelitian Dasar Unggulan Perguruan Tinggi/PDUPT) in 2022-2024.
Development of a novel outlier index for real-time detection of water level outliers for open-channel water transfer projects
Authors: Zhou Luyan , Qiao Yu , Zhang Zhao , Han Zhongkai , Lei Xiaohui , Qin Yufeng , Wang Hao
Published: May 2023

Real-time detection of water level outliers is critical for real-time regulation of gates or pump stations in open-channel water transfer projects. However, this remains a challenging task because of the lack of definition of water level outliers and the imbalance of flow monitoring data. In this study, we define the water level outliers and then propose a highly accurate outlier index for real-time detection of water level outliers based on the water level-flow relationship, and the thresholds for water level outliers are determined based on the order of magnitude of flow and water level differences. A case study is performed with the South-to-North Water Diversion Project of China. A random noise is added to 15 randomly selected non-adjacent monitoring datasets to verify the accuracy of the index, and the noise is increased from 4 to 9 cm at a step of 1 cm. The results show that a total of 159 outliers are detected out of 180 outliers with an accuracy rate of 88.3%.
Uso das ferramentas digitais em tempos de educação remota
Authors: Santos Maria Porcina de Macedo , Silva Meirylane Lopes da , Palhano Tânia Rodrigues
Published: May 2023

Este artigo discute o uso das ferramentas digitais no período da educação remota emergencial implementada na pandemia de COVID-19 e a necessidade de reconstrução dos sentidos das tecnologias na educação à luz da racionalidade hermenêutica. Para isso, recorre-se a uma revisão bibliográfica objetivando apresentar a racionalidade hermenêutica como uma possibilidade de compreensão teórico-conceitual acerca do uso das tecnologias digitais no ensino remoto. Com base na pesquisa realizada, foi possível concluir que a utilização das ferramentas digitais analisadas sob a perspectiva da racionalidade hermenêutica permite trazer a historicidade e a linguagem como base para acesso ao mundo e para o desenvolvimento dos educandos por meio da compreensão e do diálogo, em um processo de encadeamento semântico entre a tradição e a inovação do conhecimento.
Natural Anticancer Agents: Their Therapeutic Potential, Challenges
and Promising Outcomes
Authors: Tauro Savita , Dhokchawle Bharat , Mohite Popat , Nahar Deepali , Nadar Sahaya , Coutinho Evans
Published: May 2023

Cancer, the second leading cause of death worldwide, is a major health
problem. Chemotherapy, radiation therapy and surgery are current treatments for cancer.
Most anticancer drugs have severe toxic effects and are required to be administered in cycles
to reduce toxicity and prevent resistance. Plant-based drugs have shown a potential
for treatment of cancer, and various plant secondary metabolites have shown promising
antitumor activity against several cancer cell lines, such as leukemia, colon cancer, prostate
cancer, breast cancer and lung cancer. Vincristine, etoposide, topotecan and paclitaxel,
which are of natural origin, are successfully used in clinical practice, and this has generated
interest in natural compounds as anticancer agents. Some phytoconstituents like
curcumin, piperine, allicin, quercetin and resveratrol have been extensively researched
and reviewed. In the current study, we have reviewed several plants like Athyrium hohenackerianum,
Aristolochia baetica, Boswellia serrata, Panax ginseng, Berberis vulgaris,
Tanacetum parthenium, Glycine max, Combretum fragrans, Persea americana,
Raphanus sativus, Camellia sinensis, and Nigella sativa for their source, key phytoconstituents,
and anticancer activity along with their toxicity profile. Few phytoconstituents
like boswellic acid, sulforaphane and ginsenoside showed excellent anticancer activity
compared to standard drugs and are potential clinical candidates.
Recent Updates on Oncogenic Signaling of Aurora Kinases in
Chemosensitive, Chemoresistant Cancers: Novel Medicinal Chemistry
Approaches for Targeting Aurora Kinases
Authors: Kumari Pooja , Beeraka Narasimha Murthy , Tengli Anandkumar , Bannimath Gurupadayya , Baath Ramandeep Kaur , Patil Mayuri
Published: May 2023

The Aurora Kinase family (AKI) is composed of serine-threonine protein kinases
involved in the modulation of the cell cycle and mitosis. These kinases are required
for regulating the adherence of hereditary-related data. Members of this family can be categorized
into aurora kinase A (Ark-A), aurora kinase B (Ark-B), and aurora kinase C
(Ark-C), consisting of highly conserved threonine protein kinases. These kinases can modulate
cell processes such as spindle assembly, checkpoint pathway, and cytokinesis during
cell division. The main aim of this review is to explore recent updates on the oncogenic
signaling of aurora kinases in chemosensitive/chemoresistant cancers and to explore
the various medicinal chemistry approaches to target these kinases. We searched
Pubmed, Scopus, NLM, Pubchem, and Relemed to obtain information pertinent to the updated
signaling role of aurora kinases and medicinal chemistry approaches and discussed
the recently updated roles of each aurora kinases and their downstream signaling cascades
in the progression of several chemosensitive/chemoresistant cancers; subsequently,
we discussed the natural products (scoulerine, Corynoline, Hesperidin Jadomycin-B, fisetin),
and synthetic, medicinal chemistry molecules as aurora kinase inhibitors (AKIs). Several
natural products' efficacy was explained as AKIs in chemosensitization and chemoresistant
cancers. For instance, novel triazole molecules have been used against gastric cancer,
whereas cyanopyridines are used against colorectal cancer and trifluoroacetate derivatives
could be used for esophageal cancer. Furthermore, quinolone hydrazine derivatives
can be used to target breast cancer and cervical cancer. In contrast, the indole derivatives
can be preferred to target oral cancer whereas thiosemicarbazone-indole could be
used against prostate cancer, as reported in an earlier investigation against cancerous
cells. Moreover, these chemical derivatives can be examined as AKIs through preclinical
studies. In addition, the synthesis of novel AKIs through these medicinal chemistry substrates
in the laboratory using in silico and synthetic routes could be beneficial to develop
prospective novel AKIs to target chemoresistant cancers. This study is beneficial to oncologists,
chemists, and medicinal chemists to explore novel chemical moiety synthesis
to target specifically the peptide sequences of aurora kinases in several chemoresistant
cancer cell types.
WITHDRAWN: A Mini Review on Practical Synthesis of Muscimol and its Fluorinated Analogues
Authors: Abdul manan Mohd Abdul Fatah
Published: May 2023

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