bluuebunny/crossref_metadata_2025 huggingface dataset:
A Scoping Survey on Cross-reality Systems
Authors: Auda Jonas , Gruenefeld Uwe , Faltaous Sarah , Mayer Sven , Schneegass Stefan
Published: September 2023

Immersive technologies such as Virtual Reality (VR) and Augmented Reality (AR) empower users to experience digital realities. Known as distinct technology classes, the lines between them are becoming increasingly blurry with recent technological advancements. New systems enable users to interact across technology classes or transition between them—referred to as
cross-reality systems
. Nevertheless, these systems are not well understood. Hence, in this article, we conducted a scoping literature review to classify and analyze cross-reality systems proposed in previous work. First, we define these systems by distinguishing three different types. Thereafter, we compile a literature corpus of 306 relevant publications, analyze the proposed systems, and present a comprehensive classification, including research topics, involved environments, and transition types. Based on the gathered literature, we extract nine guiding principles that can inform the development of cross-reality systems. We conclude with research challenges and opportunities.
Multi-target Fluid Mixing in MEDA Biochips: Theory and an Attempt toward Waste Minimization
Authors: Kundu Debraj , Roy Sudip
Published: September 2023

Sample preparation is an inherent procedure of many biochemical applications, and digital microfluidic biochips (DMBs) have proved to be very effective in performing such a procedure. In a single mixing step, conventional DMBs can mix two droplets in a 1:1 ratio only. Due to this limitation, DMBs suffer from heavy fluid wastage and often require a lot of mixing steps. However, the next-generation DMBs, i.e., micro-electrode-dot-array (MEDA) biochips, can realize multiple mixing ratios, which in general helps in minimizing the number of mixing operations. In this article, we present a heuristic-based sample preparation algorithm, specifically a mixing algorithm calledDivision by Factor Method for MEDAthat exploits the mixing models of MEDA biochips. We propose another mixing algorithm for MEDA biochips calledSingle Target Waste Minimization(STWM), which minimizes the wastage of fluids and determines an efficient mixing graph. We also propose an advanced methodology for multiple target reagent mixing problems calledMulti-target Waste Minimization(MTWM), which determines efficient mixing graphs for different target ratios by maximizing the sharing of fluids and minimizing the fluid wastage. Simulation results suggest that the proposedSTWMandMTWMmethods outperform the state-of-the-art methods in terms of minimizing the amount of fluid wastage, reducing the total usage of reagent fluids, and minimizing the number of mixing operations.
Cancer survivors post-chemotherapy exhibit unimpaired short-latency stretch reflexes in the proximal upper extremity
Authors: Wang Allison B. , Housley Stephen N. , Ludvig Daniel , Franz Colin K. , Flores Ann Marie , Cope Timothy C. , Perreault Eric J.
Published: September 2023

Our results showed that cancer survivors after oxaliplatin (OX) treatment exhibited stretch reflexes that were comparable with age-matched healthy individuals in the proximal upper limb. The lack of OX effect might be linked to differences between the clinical and preclinical testing paradigms. These findings refine our expectations derived from the preclinical study and guide future assessments of OX effects that may have been insensitive to our measurement techniques.
Performing a vibrotactile discrimination task modulates finger representations in primary somatosensory cortex
Authors: Rabe Finn , Kikkert Sanne , Wenderoth Nicole
Published: September 2023

Using multivoxel pattern analysis, we found that discrimination task demands shape finger representations in the contralateral primary somatosensory cortex (S1), and that somatotopic representations are modulated by task demands not only during tactile stimulation but also to a certain extent in the absence of tactile input.
Prediction of Equivalence Ratio in Combustion Flame Using Chemiluminescence Emission and Deep Neural Network
Authors: Shin Sanghun , Kwon Minjun , Kim Sewon , So Hongyun
Published: September 2023

A reliable combustion monitoring system is essential to satisfy global carbon neutrality trends. As the concentrations of emissions and flame stability are associated with the air–fuel ratio, the equivalence ratio should be continuously evaluated. In this study, a deep neural network- (DNN-) based regression model is proposed to predict the equivalence ratio of turbulent diffusion flames. Chemiluminescence signals from the OH

∗

, CH

∗

, and C2

∗

radicals were acquired as input features. In addition, three different optical sensing views were applied to consider the future general measurement conditions. Furthermore, a loss function comparison for model training and hyperparameter tuning techniques, such as random search and Bayesian optimization, were used to improve the prediction performance. Consequently, the enhanced DNN model showed reductions in the mean absolute error and root mean square error of ~17.84% and ~12.06%, respectively, compared with the initial model. In addition, a mean absolute percentage error and

R

-squared value of ~3.61% and ~0.9311, respectively, were obtained. Thus, a novel sensing method has been proposed for flame monitoring systems to realize future digital transformations in the combustion industry.
Investigating the Optimal Treatment to Improve Cashew Apple Juice Quality and Shelf Life
Authors: Aluko Angela , Kassim Neema , Makule Edna
Published: September 2023

An investigation was carried out to extend the shelf life of cashew apple juice (CAJ) by up to 90 days from its natural shelf life. CAJ was obtained by pressing apples. Then, extracted juice was clarified, pasteurized, and added with preservatives, citric acid (0.01%), and sodium benzoate (0.01%). The juice was analyzed for physicochemical qualities, sugars, microbial (total bacteria, yeast, and mould) and sensory evaluation tests for appearance (yellow and brown color), aroma, and taste (astringent, bitter, and sweet). CAJ was stored at refrigeration (4°C) and ambient temperature (22.6-32.5°C) for 90 days. Sensory and shelf life analyses were conducted at 0, 15, 30, 45, 60, 75, and 90 days during storage. The results showed that cashew apple juice had strong vitamin C content (256.5 mg/100 mL). At ambient storage, there was high decrease of vitamin C (6.2-59.8%) and low decrease at refrigeration storage (1.6-10.5%). pH was found to decrease (4.4-3.15) and TSS (11–10.6°Bx), while titratable acidity (0.4–0.59%) increases with time at refrigerating storage. Also, at ambient storage, CAJ showed the similar trend, having decrease in pH (4.4-3.06) and TSS (11-10.3°Bx), while titratable acidity increased (0.4-0.61%). Moreover, sugar content for juice had minimum and maximum decrease at refrigeration and ambient temperatures, respectively. Storage at ambient temperature resulted in growth of microbes which was observed after 15 days for juices without preservatives and 75 days for juices with preservatives, with no E. coli growth. Juice on refrigeration had higher intensity of yellow color (7.50) and sweetness (5.58) while low intensity for astringency (1.58) (

p
<
0.05

). Sensory evaluation of the beverage was found to be satisfactory. Thus, shelf life of cashew apple juice was extended to 90 days satisfactorily, ensuring consumption-safe parameters and satisfactory sensory qualities.
Driving Profile Optimization Using a Deep Q‐Network to Enhance Electric Vehicle Battery Life
Authors: Kwon Jihoon , Kim Manho , Kim Hyeongjun , Lee Minwoo , Lee Suk
Published: September 2023

In the COVID‐19 era, automobiles with internal combustion engines are being replaced by eco‐friendly vehicles. The demand for battery electric vehicles (BEVs) has increased explosively. Treatment of spent batteries has received much attention. Battery life can be extended via both efficient charging and driving. Consideration of the vehicles ahead when driving a BEV effectively prolongs battery life. Several studies have presented eco‐friendly driving profiles for BEVs, the cited authors did not develop a BEV driving profile that considered battery life using reinforcement learning. Here, this paper presents a method of driving profile optimization that increases BEV battery life. This paper does not address how to regenerate spent batteries in an eco‐friendly manner. The BEV driving profile is optimized employing a deep Q‐network (a reinforcement learning method). This paper uses simulations to evaluate the effect of the driving profile on BEV battery life; these verified the applicability of our model. Finally, the speed profile optimization method was limited to improve energy efficiency or battery life in rapid speed change sections.
Effects of Soil and Water Conservation Practices and Slope Gradient on Selected Soil Physicochemical Properties in Ejersa Watershed, Toke Kutaye District, Ethiopia
Authors: Kebede Negesu , Negassa Alemayehu
Published: September 2023

This study was conducted to assess the effects of soil and water conservation practices and slope gradients on selected physicochemical properties of soil at Ejersa Watershed based on a total of 18 composite soil samples collected and analyzed using standard laboratory procedures. The values of pH, electrical conductivity, cation exchangeable capacity, organic carbon, organic matter, total nitrogen, and available phosphorus determined in soil samples collected from conserved and nonconserved plots were 6.4 and 6.16, 40.26 mS/m and 15.12 mS/m, 33.51 meq/100 g and 21.56 meq/100 g, 2.66% and 2.24%, 4.58% and 3.86%, 0.24% and 0.15%, and 29.45 ppm and 17.68 ppm, respectively. Soil pH, electrical conductivity, moisture, total nitrogen, and available phosphorus were significantly different (

p
<
0.01

) between treated and untreated plots and among the slope classes. Values of soil organic carbon and organic matter showed significant differences (

p
<
0.05

) between land types but not among the slope classes. Soil cation exchange capacity showed significant difference (

p
<
0.05

) between land types as well as among the slope classes. Relatively, higher values of many of the physicochemical parameters were recorded in samples collected from the treated land and lower slopes which might be attributed to the deposition effects of the conservation practices and decline in the rate of soil erosion.
Comparison of Encased Stone Column with Conventional Column for Varied Parameters through Experimental and Numerical Investigations
Authors: S. V. Sivapriya , James Jijo , Pavithra K. , Renuka Devi S. , Sangeetha K. , Sasikala M.
Published: September 2023

Installation of stone columns is a widely used stabilization method in improving the characteristics of soft clays. In this study, laboratory tests were conducted to understand the influence of column number, spacing and encasement on the load-carrying capacity of the modified soil. Unit cell concept is adopted for column diameters of 25.4 and 31.75 mm, one and two numbers of columns and spacings of 50, 70, and 90 mm under the conditions of with and without encasement. In addition to the laboratory study, finite element analysis was also done for similar parameters to understand the modified soil’s settlement characteristics and stress concentration ratio. Based on the analysis, it is understood that the load-carrying capacity increases with number of columns and spacing. Considering the influence of encasement, larger diameter columns showed a more significant increase in the load-carrying capacity when compared to the smaller diameter columns.
Data from A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies
Authors: Zitzmann-Kolbe Sabine , Kristian Alexander , Zopf Dieter , Kamfenkel Claudia , Politz Oliver , Ellingsen Christine , Hilbig Jochen , Juul Mark U. , Fonslet Jesper , Nielsen Carsten H. , Schatz Christoph A. , Bjerke Roger M. , Cuthbertson Alan S. , Mumberg Dominik , Hagemann Urs B.
Published: September 2023

Abstract
Targeted alpha therapies (TAT) are an innovative class of therapies for cancer treatment. The unique mode-of-action of TATs is the induction of deleterious DNA double-strand breaks. Difficult-to-treat cancers, such as gynecologic cancers upregulating the chemoresistance P-glycoprotein (p-gp) and overexpressing the membrane protein mesothelin (MSLN), are promising targets for TATs. Here, based on the previous encouraging findings with monotherapy, we investigated the efficacy of the mesothelin-targeted thorium-227 conjugate (MSLN-TTC) both as monotherapy and in combination with chemotherapies and antiangiogenic compounds in ovarian and cervical cancer models expressing p-gp. MSLN-TTC monotherapy showed equal cytotoxicity in vitro in p-gp–positive and -negative cancer cells, while chemotherapeutics dramatically lost activity on p-gp–positive cancer cells. In vivo, MSLN-TTC exhibited dose-dependent tumor growth inhibition with treatment/control ratios of 0.03–0.44 in various xenograft models irrespective of p-gp expression status. Furthermore, MSLN-TTC was more efficacious in p-gp–expressing tumors than chemotherapeutics. In the MSLN-expressing ST206B ovarian cancer patient-derived xenograft model, MSLN-TTC accumulated specifically in the tumor, which combined with pegylated liposomal doxorubicin (Doxil), docetaxel, bevacizumab, or regorafenib treatment induced additive-to-synergistic antitumor efficacy and substantially increased response rates compared with respective monotherapies. The combination treatments were well tolerated and only transient decreases in white and red blood cells were observed. In summary, we demonstrate that MSLN-TTC treatment shows efficacy in p-gp–expressing models of chemoresistance and has combination potential with chemo- and antiangiogenic therapies.
Data from T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
Authors: Lam Vi , Roleder Carly , Liu Tingting , Bruss Nur , Best Scott , Wang Xiaoguang , Phillips Tycel , Shouse Geoffrey , Berger Allison J. , Alinari Lapo , Wang Lili , Siddiqi Tanya , Pennock Nathan D. , Danilov Alexey V.
Published: September 2023

Abstract
Novel targeted agents used in therapy of lymphoid malignancies are recognized to have complex immune-mediated effects. Sumoylation, a posttranslational modification of target proteins by small ubiquitin-like modifiers (SUMO), regulates a variety of cellular processes indispensable in immune cell activation. Despite this, the role of sumoylation in T-cell biology in context of cancer is not known. TAK-981 (subasumstat) is a small-molecule inhibitor of the SUMO-activating enzyme (SAE) that forms a covalent adduct with an activated SUMO protein. Using T cells derived from patients with chronic lymphocytic leukemia (CLL), we demonstrate that targeting SAE activates type I IFN response. This is accompanied by largely intact T-cell activation in response to T-cell receptor engagement, with increased expression of CD69 and CD38. Furthermore, TAK-981 decreases regulatory T cell (Treg) differentiation and enhances secretion of IFNγ by CD4+ and CD8+ T cells. These findings were recapitulated in mouse models, suggesting an evolutionarily conserved mechanism of T-cell activation regulated by SUMO modification. Relevant to the consideration of TAK-981 as an effective agent for immunotherapy in hematologic malignancies, we demonstrate that the downstream impact of TAK-981 administration is enhancement of the cytotoxic function of CD8+ T cells, thus uncovering immune implications of targeting sumoylation in lymphoid neoplasia.
Data from Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures
Authors: Chang Stephen H. , Ice Ryan J. , Chen Michelle , Sidorov Maxim , Woo Rinette W.L. , Rodriguez-Brotons Aida , Jian Damon , Kim Han Kyul , Kim Angela , Stone David E. , Nazarian Ari , Oh Alyssia , Tranah Gregory J. , Nosrati Mehdi , de Semir David , Dar Altaf A. , Desprez Pierre-Yves , Kashani-Sabet Mohammed , Soroceanu Liliana , McAllister Sean D.
Published: September 2023

Abstract
As a result of tumor heterogeneity and solid cancers harboring multiple molecular defects, precision medicine platforms in oncology are most effective when both genetic and pharmacologic determinants of a tumor are evaluated. Expandable patient-derived xenograft (PDX) mouse tumor and corresponding PDX culture (PDXC) models recapitulate many of the biological and genetic characteristics of the original patient tumor, allowing for a comprehensive pharmacogenomic analysis. Here, the somatic mutations of 23 matched patient tumor and PDX samples encompassing four cancers were first evaluated using next-generation sequencing (NGS). 19 antitumor agents were evaluated across 78 patient-derived tumor cultures using clinically relevant drug exposures. A binarization threshold sensitivity classification determined in culture (PDXC) was used to identify tumors that best respond to drug in vivo (PDX). Using this sensitivity classification, logic models of DNA mutations were developed for 19 antitumor agents to predict drug response. We determined that the concordance of somatic mutations across patient and corresponding PDX samples increased as variant allele frequency increased. Notable individual PDXC responses to specific drugs, as well as lineage-specific drug responses were identified. Robust responses identified in PDXC were recapitulated in vivo in PDX-bearing mice and logic modeling determined somatic gene mutation(s) defining response to specific antitumor agents. In conclusion, combining NGS of primary patient tumors, high-throughput drug screen using clinically relevant doses, and logic modeling, can provide a platform for understanding response to therapeutic drugs targeting cancer.
Data from S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
Authors: Nagira Yoji , Nagira Morio , Nagai Ryohei , Nogami Wataru , Hirata Michinari , Ueyama Azumi , Yoshida Tetsuya , Yoshikawa Mai , Shinonome Satomi , Yoshida Hiroshi , Haruna Miya , Miwa Hiroto , Chatani Natsumi , Ohkura Naganari , Wada Hisashi , Tanaka Hidekazu
Published: September 2023

Abstract
Although regulatory T cells (Treg) are inhibitory immune cells that are essential for maintaining immune homeostasis, Tregs that infiltrate tumor tissue promote tumor growth by suppressing antitumor immunity. Selective reduction of tumor-infiltrating Tregs is, therefore, expected to activate antitumor immunity without affecting immune homeostasis. We previously reported that selective Treg depletion targeted by a C-C motif chemokine receptor 8 (CCR8) resulted in induction of strong antitumor immunity without any obvious autoimmunity in mouse models. Thus, herein, we developed a novel humanized anti-CCR8 monoclonal antibody, S-531011, aimed as a cancer immunotherapy strategy for patients with cancer. S-531011 exclusively recognized human CCR8 among all chemokine receptors and showed potent antibody-dependent cell-mediated cytotoxicity activity toward CCR8+ cells and neutralization activity against CCR8-mediated signaling. We observed that S-531011 reduced tumor-infiltrating CCR8+ Tregs and induced potent antitumor activity in a tumor-bearing human-CCR8 knock-in mouse model. Moreover, combination therapy with S-531011 and anti-mouse programmed cell death 1 (PD-1) antibody strongly suppressed tumor growth compared with anti–PD-1 antibody alone with no observable adverse effects. S-531011 also depleted human tumor-infiltrating Tregs, but not Tregs derived from human peripheral blood mononuclear cells. These results suggest that S-531011 is a promising drug for inducing antitumor immunity without severe side effects in the clinical setting.
Data from Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer
Authors: Toader Dorin , Fessler Shawn P. , Collins Scott D. , Conlon Patrick R. , Bollu Reddy , Catcott Kalli C. , Chin Chen-Ni , Dirksen Anouk , Du Bingfan , Duvall Jeremy R. , Higgins Stacy , Kozytska Mariya V. , Bellovoda Kamela , Faircloth Chelsey , Lee David , Li Fu , Qin Liuliang , Routhier Caitlin , Shaw Pamela , Stevenson Cheri A. , Wang Jason , Wongthida Phonphimon , Ter-Ovanesyan Elena , Ditty Elizabeth , Bradley Stephen P. , Xu Ling , Yin Mao , Yurkovetskiy Aleksandr V. , Mosher Rebecca , Damelin Marc , Lowinger Timothy B.
Published: September 2023

Abstract
Antibody-drug conjugates (ADCs) achieve targeted drug delivery to a tumor and have demonstrated clinical success in many tumor types. The activity and safety profile of an ADC depends on its construction: antibody, payload, linker, and conjugation method, as well as the number of payload drugs per antibody (drug-to-antibody ratio, DAR). To allow for ADC optimization for a given target antigen, we developed Dolasynthen, a novel ADC platform based on the payload auristatin hydroxypropylamide (AF-HPA), that enables precise DAR-ranging and site-specific conjugation. We used the new platform to optimize an ADC that targets B7-H4 (VTCN1), an immune-suppressive protein that is overexpressed in breast, ovarian, and endometrial cancers. XMT-1660 is a site-specific Dolasynthen DAR 6 ADC that induced complete tumor regressions in xenograft models of breast and ovarian cancer as well as in a syngeneic breast cancer model that is refractory to PD-1 immune checkpoint inhibition. In a panel of 28 breast cancer patient-derived xenografts (PDX), XMT-1660 demonstrated activity that correlated with B7-H4 expression. XMT-1660 has recently entered clinical development in a Phase 1 study (NCT05377996) in cancer patients.
Data from Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer
Authors: Toader Dorin , Fessler Shawn P. , Collins Scott D. , Conlon Patrick R. , Bollu Reddy , Catcott Kalli C. , Chin Chen-Ni , Dirksen Anouk , Du Bingfan , Duvall Jeremy R. , Higgins Stacy , Kozytska Mariya V. , Bellovoda Kamela , Faircloth Chelsey , Lee David , Li Fu , Qin Liuliang , Routhier Caitlin , Shaw Pamela , Stevenson Cheri A. , Wang Jason , Wongthida Phonphimon , Ter-Ovanesyan Elena , Ditty Elizabeth , Bradley Stephen P. , Xu Ling , Yin Mao , Yurkovetskiy Alexandr V. , Mosher Rebecca , Damelin Marc , Lowinger Timothy B.
Published: September 2023

Abstract
Antibody–drug conjugates (ADC) achieve targeted drug delivery to a tumor and have demonstrated clinical success in many tumor types. The activity and safety profile of an ADC depends on its construction: antibody, payload, linker, and conjugation method, as well as the number of payload drugs per antibody [drug-to-antibody ratio (DAR)]. To allow for ADC optimization for a given target antigen, we developed Dolasynthen (DS), a novel ADC platform based on the payload auristatin hydroxypropylamide, that enables precise DAR-ranging and site-specific conjugation. We used the new platform to optimize an ADC that targets B7-H4 (VTCN1), an immune-suppressive protein that is overexpressed in breast, ovarian, and endometrial cancers. XMT-1660 is a site-specific DS DAR 6 ADC that induced complete tumor regressions in xenograft models of breast and ovarian cancer as well as in a syngeneic breast cancer model that is refractory to PD-1 immune checkpoint inhibition. In a panel of 28 breast cancer PDXs, XMT-1660 demonstrated activity that correlated with B7-H4 expression. XMT-1660 has recently entered clinical development in a phase I study (NCT05377996) in patients with cancer.
Data from A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development
Authors: Dickinson Michael J. , Barba Pere , Jäger Ulrich , Shah Nirav N. , Blaise Didier , Briones Javier , Shune Leyla , Boissel Nicolas , Bondanza Attilio , Mariconti Luisa , Marchal Anne-Laure , Quinn David S. , Yang Jennifer , Price Andrew , Sohoni Akash , Treanor Louise M. , Orlando Elena J. , Mataraza Jennifer , Davis Jaclyn , Lu Darlene , Zhu Xu , Engels Boris , Moutouh-de Parseval Laure , Brogdon Jennifer L. , Moschetta Michele , Flinn Ian W.
Published: September 2023

Abstract
CAR T-cell product quality and stemness (Tstem) are major determinants of in vivo expansion, efficacy, and clinical response. Prolonged ex vivo culturing is known to deplete Tstem, affecting clinical outcome. YTB323, a novel autologous CD19-directed CAR T-cell therapy expressing the same validated CAR as tisagenlecleucel, is manufactured using a next-generation platform in <2 days. Here, we report the preclinical development and preliminary clinical data of YTB323 in adults with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL; NCT03960840). In preclinical mouse models, YTB323 exhibited enhanced in vivo expansion and antitumor activity at lower doses than traditionally manufactured CAR T cells. Clinically, at doses 25-fold lower than tisagenlecleucel, YTB323 showed (i) promising overall safety [cytokine release syndrome (any grade, 35%; grade ≥3, 6%), neurotoxicity (any grade, 25%; grade ≥3, 6%)]; (ii) overall response rates of 75% and 80% for DL1 and DL2, respectively; (iii) comparable CAR T-cell expansion; and (iv) preservation of T-cell phenotype. Current data support the continued development of YTB323 for r/r DLBCL.
Significance:
Traditional CAR T-cell manufacturing requires extended ex vivo cell culture, reducing naive and stem cell memory T-cell populations and diminishing antitumor activity. YTB323, which expresses the same validated CAR as tisagenlecleucel, can be manufactured in <2 days while retaining T-cell stemness and enhancing clinical activity at a 25-fold lower dose.

See related commentary by Wang, p. 1961.

This article is featured in Selected Articles from This Issue, p. 1949
Data from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
Authors: Facchinetti Francesco , Hollebecque Antoine , Braye Floriane , Vasseur Damien , Pradat Yoann , Bahleda Rastislav , Pobel Cédric , Bigot Ludovic , Déas Olivier , Florez Arango Juan David , Guaitoli Giorgia , Mizuta Hayato , Combarel David , Tselikas Lambros , Michiels Stefan , Nikolaev Sergey I. , Scoazec Jean-Yves , Ponce-Aix Santiago , Besse Benjamin , Olaussen Ken A. , Loriot Yohann , Friboulet Luc
Published: September 2023

Abstract
Several fibroblast growth factor receptor (FGFR) inhibitors are approved or in clinical development for the treatment of FGFR-driven urothelial cancer, and molecular mechanisms of resistance leading to patient relapses have not been fully explored. We identified 21 patients with FGFR-driven urothelial cancer treated with selective FGFR inhibitors and analyzed postprogression tissue and/or circulating tumor DNA (ctDNA). We detected single mutations in the FGFR tyrosine kinase domain in seven (33%) patients (FGFR3 N540K, V553L/M, V555L/M, E587Q; FGFR2 L551F) and multiple mutations in one (5%) case (FGFR3 N540K, V555L, and L608V). Using Ba/F3 cells, we defined their spectrum of resistance/sensitivity to multiple selective FGFR inhibitors. Eleven (52%) patients harbored alterations in the PI3K–mTOR pathway (n = 4 TSC1/2, n = 4 PIK3CA, n = 1 TSC1 and PIK3CA, n = 1 NF2, n = 1 PTEN). In patient-derived models, erdafitinib was synergistic with pictilisib in the presence of PIK3CA E545K, whereas erdafitinib–gefitinib combination was able to overcome bypass resistance mediated by EGFR activation.
Significance:
In the largest study on the topic thus far, we detected a high frequency of FGFR kinase domain mutations responsible for resistance to FGFR inhibitors in urothelial cancer. Off-target resistance mechanisms involved primarily the PI3K–mTOR pathway. Our findings provide preclinical evidence sustaining combinatorial treatment strategies to overcome bypass resistance.

See related commentary by Tripathi et al., p. 1964.

This article is featured in Selected Articles from This Issue, p. 1949
Treatment Beyond Progression After Anti-PD-1 Blockade in Hepatocellular Carcinoma
Authors: Lim Mir , Muquith Maishara , Miramontes Bernadette , Espinoza Magdalena , Hsiehchen David
Published: September 2023

Immune checkpoint inhibitors (ICI) can induce atypical tumor responses including pseudoprogression in a subset of patients who may benefit from treatment beyond progression. While ICIs have emerged as frontline treatments for hepatocellular carcinoma (HCC) and are associated with clinical benefit in a minority of patients, it is unclear whether treatment beyond progression has utility in this disease type. In a multicenter cohort analysis, treatment beyond progression was associated with no new safety signals, objective responses in 5.8% of patients, and disease control in 44% of patients. Progression-free survival and overall survival were comparable between patients treated beyond progression and patients treated with subsequent therapies, demonstrating that treatment beyond progression was not detrimental to survival outcomes. Rather, treatment beyond progression may benefit select patients with HCC and could represent a viable strategy for maximizing treatment benefit in these patients.

Significance:

Treatment beyond progression with ICIs in patients with HCC is safe and may benefit a subset of patients due to later-onset tumor responses or disease stability. These findings may guide the design of trials testing ICIs in HCC and the use of treatment beyond progression in routine practice.
Profitability of Broiler Production on Diets Containing Ground Peanut (Arachis hypogaea) Shell as a Potential Alternative Feed Ingredient
Authors: Moniño Analyn M. , Ibañez, Jr. Roger Y. , Moniño Primitivo D.
Published: September 2023

The study investigated the effects of incorporating ground peanut shells into broiler diets on growth performance, feed conversion efficiency, and production cost. The results showed that broilers fed diets with ground peanut shells had improved growth performance and body weight compared to those without. Moreover, the inclusion of ground peanut shells in broiler diets improved feed conversion efficiency, indicating a reduction in the amount of feed required for broiler growth. The findings suggest that ground peanut shells can be used as a safe and effective feed ingredient for broilers without compromising their health and survival. The utilization of agricultural by-products such as peanut shells in the poultry industry can have significant benefits. Incorporating ground peanut shells into broiler diets can reduce production expenses while providing essential nutrients for human consumption. This can result in an increase in income for households involved in poultry raising. Furthermore, the use of agricultural by-products can contribute to reducing environmental waste, leading to a more sustainable and environmentally friendly poultry industry. The study highlights the potential of utilizing agricultural by-products such as peanut shells in the poultry industry. Incorporating ground peanut shells into broiler diets can reduce production costs, increase income for households involved in poultry raising, and provide essential nutrients for human consumption.
Decision-Making Competence and Critical Thinking Ability among Triage Nurses in a Selected Hospital in Batangas, Philippines
Authors: Comia Rejie Lunar , Floranda Lualhati Maxima M. , Durante Cherry Ann Garcia
Published: September 2023

Overcrowding and long waiting times remain perennial issues in many emergency departments globally, resulting in unsafe and inefficient care. To facilitate the treatment of patients that arrive in the Emergency Department a triage process is often implemented. Triage enables the Emergency Department staff to prioritize patient care so that patients requiring more immediate care are seen first. This study described the competence and critical thinking ability of triage nurses in a selected hospital in Lipa City, Batangas, Philippines. The quantitative descriptive correlational research design was used in this study. Data was gathered through a self-administered questionnaire that adopted Yoon Critical Thinking Disposition and Triage Decision Making Inventory by Cone (2000). Results showed that decision-making competency is significantly different among different age groups (F=40.93, p<0.0001). Respondents’ critical thinking ability based on objectivity, healthy scepticism, systematicity and intellectual fairness, intellectual curiosity, self-confidence and prudence was at moderate level, with composite means of 3.23, 3.43, 3.22, 3.37, 3.33, 3.28, and 3.27, respectively.  Based on the results of the study, participants had a moderate level of critical thinking ability while doing triage. Also, over-all decision-making ability significantly increased with age and years of experience. Furthermore, objectivity, self-confidence, prudence and over-all critical thinking ability are significantly associated with age. Moreover, the triage nurses’ decision-making skills can be greatly influenced by their critical thinking ability.
Retraction Notice "The Challenges of Impementation of Developing A Tod Area in Thessaloni-ki, Greece"
Authors: Sasmit Anjar , Riyanti Nova
Published: September 2023

RETRACTION TO: Sasmit, A., & Riyanti, N. (2023). The Challenges of Impementation of Developing A Tod Area in Thessaloni-ki, Greece. International Journal of Multidisciplinary: Applied Business and Education Research, 4(8), 2765-2774. https://doi.org/10.11594/ijmaber.04.08.16 . This article has been retracted by the publisher to be in violation of IJMABER Publication Ethics. IJMABER requires authors to declare that their work is original and has not been published or considered by another journal. This article is a serious misuse of scientific publishing. The scientific community strongly disapproves of this, and the journal apologizes to readers for not catching it during submission. The presenting author of this paper has the option to appeal this decision by contacting editor.ijmaber@futuresciencepress.com.
Differentiated Instruction for an Enhanced Students’Academic Performance in Science 10 (PHYSICS)
Authors: Toledo Flordelyn L.
Published: September 2023

The study aimed to determine the effectiveness of Differentiated Instruction strategy using selected Multiple Intelligences activities on the students’ performance in Science 10 (Physics). The researcher employed quasi-experimental research and a descriptive method utilizing questionnaires as the principal tool to gather the data. The respondents involved in the study were the One Hundred Twenty (120) Grade 10 Junior High School students of Bagong Nayon II National High School, Antipolo City, during the school year 2022-2023. They were grouped according to their dominant Multiple Intelligence. The study revealed that among the first five dominant multiple intelligences of the students, the majority of the students are more on intrapersonal intelligence rather than the other. This implies that some of the respondents perform more in intrapersonal tasks and skills which would then indicate that teachers should assess each learner's multiple intelligence to know and enhance students' performance in academics. The use of Differentiated Instruction in teaching Science 10 (Physics) greatly improved the performance of the students in terms of their academics. This was shown on the pretest and posttest performance of the students in which their posttest performance increased greatly after the utilization of  differentiated instruction in teaching Science 10. It can also be noted that the Intrapersonal Group of students got the highest increase in mean score. The average mean score in the pretest is 19.49 and 35.69 in the posttest with the mean increase of 16.20. This implies that although the students were given different activities, they all performed well. Based on the findings of the study, teachers can use differentiated instruction for the purpose of enhancing the academic performance of the students. This also implies that the prepared activities intended for these groups of students were effective. Therefore, a student-focused approach of teaching fosters an effective learning environment and excellent academic performance.
Contract Management System among Selected Construction Companies in Qatar
Authors: Polinar Mark Anthony N. , Dela Cruz Gerelyn S.
Published: September 2023

The State of Qatar's construction industry proliferates, attracting international investors and contractors to large-scale projects. This growth, however, is accompanied by an inevitable increase in claims and disputes, causing significant delays and additional costs to the project. The study’s focus is to understand better the practical problems affecting the contract management system’s efficiencies in selected construction companies in Qatar. A descriptive correlational research design method was carried out using a survey questionnaire to determine the degree of importance and awareness of the contract management system in terms of risk, change, and claim management. Also, the results revealed that employees perceived risk, change, and claim management as integral parts of the contract management system. A Pearson correlation coefficient was used to test the correlation between the variables covered in the study, and the statistical evidence concluded that there is a significant strong linear relationship between the degree of importance and awareness in the contract management system. Therefore, based on the literature presented in this study and the data gathered from fifty-two respondents who voluntarily participated in the survey, the authors recommended that the organizations must embrace these contract management methods to cut costs, shorten lead times, and boost profitability: clear dispute resolution procedures, precise change control procedures, proper record keeping, effective risk mitigation plan, competent team members, and the organization's capability and readiness to resort to arbitration when other dispute resolution procedures are exhausted.
Narrativas turísticas de paisagens escravistas: práticas de memória na interpretação do patrimônio cultural do Vale do Paraíba, SP
Authors: Gagliardi Clarissa Maria Rosa
Published: September 2023

O texto analisa as narrativas turísticas como práticas de memória, discutindo sua relevância no reconhecimento do papel dos negros escravizados na construção social de cidades históricas brasileiras e seus patrimônios. O estudo se concentra no Vale Histórico, localizado entre Rio de Janeiro e São Paulo, cuja história esteve marcada pela lavoura cafeeira e pela presença maciça de escravizados africanos e seus descendentes no século XIX. A partir da análise de visitas oferecidas em fazendas cafeeiras convertidas para uso turístico, observa-se como a instituição da escravidão, a presença e a individualidade dos escravizados são minimizadas ou invisibilizadas nestes programas turísticos, não obstante a extensão, a produtividade e o contingente de negros escravizados tenham sido enormes nessa região. O trabalho é um recorte dos resultados da pesquisa Turismo, Patrimônio e Desenvolvimento Social no Vale Histórico Paulista, desenvolvida na Universidade de São Paulo e financiada pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Um patrimônio centenário em Brasília: processos patrimoniais e discursos relativos a antecedentes da Nova Capital
Authors: Barbosa Daniela Pereira , Derntl Maria Fernanda
Published: September 2023

Este trabalho consiste numa análise documental de dossiês de tombamento relativos a construções erguidas antes da construção de Brasília e localizadas no território do Distrito Federal. Trata-se do Museu Histórico e Artístico de Planaltina, da Igreja São Sebastião de Planaltina, da Pedra Fundamental de Planaltina e da Casa da Fazenda Gama, que, por sua arquitetura e origem, contrastam com a monumentalidade moderna do Plano Piloto de Brasília. O método consistiu em coleta de dados de dossiês e análise de justificativas para os tombamentos expressas nessa documentação, o que nos permitiu investigar como ocorreu a incorporação de uma alegada "tradição goiana" em discursos patrimoniais relativos a Brasília. Nossas conclusões apontam como esse patrimônio é valorizado nos dossiês, sobretudo por seu papel no processo de implantação e construção da nova capital, em uma tentativa de reforçar a imagem monumental de Brasília.
O BIM como instrumento para gestão da manutenção e operação de edificações: um panorama atual
Authors: Nascimento Claudia Rafaela Saraiva de Melo Simões , Morais Gabriela Alves Tenório de , Palha Rachel Perez , Dourado Anísio Brasileiro de Freitas , Andrade Maurício Oliveira de
Published: September 2023

Existe uma lacuna no conhecimento sobre a aplicação do BIM para Operação e Manutenção (O&M), fases que apresentam grande impacto nos custos do ciclo de vida de uma edificação. Esta pesquisa objetiva estabelecer um panorama do uso do BIM para gestão de O&M de edificações. Para tal, foram realizadas revisões na literatura sobre: (1) o uso do BIM para gestão O&M das instalações; (2) os Mandatos para a implementação do BIM; (3) as experiências e metodologias de implementação do BIM para O&M de edificações. Por fim, uma análise crítica dos dados foi feita e verificou-se que uso do BIM para O&M tem potencial para variados tipos de edificações, podendo solucionar problemas que vão além da gestão das atividades de manutenção. Além disso, destacou-se as potencialidades da integração ente o BIM e diversas tecnologias, como nuvens de dados e a realidade aumentada, o que permite análise e atualização em tempo real das informações. Porém o uso do BIM para O&M ainda é um campo de pesquisa emergente e necessita de avanços. Pesquisas para desenvolvimento de metodologias para integração BIM-O&M voltadas para empreendimentos públicos e estudos de caso no Brasil são exemplos de estudos que precisam ser feitos.
Mobiliário urbano de código aberto: estímulo para projetos colaborativos
Authors: Gomes Mayara Carvalho , Colchete Filho Antonio Ferreira
Published: September 2023

Com as cidades cada vez mais populosas, novas estratégias para o espaço público vêm sendo pensadas com vistas ao aumento das possibilidades de autoconstrução, compartilhamento e facilitação através de meios tecnológicos e ao estímulo ao envolvimento da população em ações coletivas. A colaboração de profissionais mediante a criação e a formulação de mobiliários urbanos de código aberto (open source) tem se revelado uma estratégia inovadora com resultados para reflexão. A partir de pesquisa de mestrado sobre o tema, realizada em Programa de Pós-graduação da Universidade Federal de Juiz de Fora, repassam-se neste artigo conceitos e aportes teóricos sobre esta possibilidade de intervenção, e o entendimento e sistematização das questões envolvidas no seu desenvolvimento e nas suas distintas práticas de execução. Com metodologia centrada na revisão sistemática e narrativa de literatura, sintetizam-se ideias-chave a partir dos principais descritores selecionados, dos conceitos constituintes do seu processo, e de três projetos que subsidiam a discussão sobre a produção dessa tipologia na atualidade. Conclui-se que há ganhos importantes em ações colaborativas que envolvem o mobiliário urbano, tanto para o espaço e a população que acolhem as intervenções, como para o campo disciplinar, que avança em discussões sobre processos participativos integrados aos profissionais nas diferentes fases do projeto e no incentivo à modificação e execução por parte dos usuários.
Música para a Vida: bem-estar e saúde mental em crianças estimuladas com educação musical baseada em metodologias ativas em grupos de estudo de música religiosa
Authors: Cervantes Ana Mary de , Silva Josilene Andrade da , Medeiros Priscila , Freitas Renato Leonardo de
Published: September 2023

As práticas e metodologias ativas são de grande importância para a área de educação musical. Há poucos estudos evidenciando a análise da formação musical e a abordagem de materiais pedagógicos musicais em contextos religiosos. A educação musical que pode contribuir com o processo de aprendizagem, a qualidade de vida, a sociabilização, a expressão e reabilitação psicossocial dos participantes. Sendo assim, através desta revisão, pretendemos incentivar e elucidar as práticas de metodologias ativas no ensino musical de crianças e relacionar a melhora da qualidade de vida, bem-estar e da saúde mental. Além disso, pretendemos explorar o quanto pode ser significativo o processo de ensino e aprendizagem com crianças que tocam os hinos evangélicos em teclados e em orquestras, assim como ilustrar uma metodologia que auxilie a compreensão dos referenciais teóricos de forma lúdica através de atividades com apoio de metodologias ativas de vários pedagogos musicais ao longo de nossa história. E, por fim, pretendemos relacionar o tema de educação musical, os benefícios das metodologias ativas, assim como, evidenciar os benefícios da educação musical sobre a qualidade de vida, o bem-estar e a saúde mental dos participantes que passam pelo processo de aprendizagem musical.
O uso da música nos dramas jesuíticos austríacos
Authors: Griman Caio Amadatsu
Published: September 2023

Embora a música tenha sido usada com grandes restrições nas produções dramáticas jesuíticas no século XVI, a partir do século seguinte, essa situação começou a mudar e, aos poucos, tornou-se comum encontrar algumas partes escritas para recitativo solo e ária. A partir da segunda metade do século XVII, um número crescente de dramas jesuíticos passou a ser inteiramente cantado. Ademais, apesar do fascínio da elite austríaca pela ópera italiana e do contínuo financiamento de produções operísticas, o patrocínio destes dramas tornou-se uma alternativa conveniente e mais barata a esse gênero profano italiano. Através dos empreendimentos teatrais da Companhia de Jesus, as principais autoridades austríacas encontraram uma alternativa para se entreter com as novas técnicas composicionais típicas da ópera a partir de uma produção artística considerada moralmente edificante e adequada a indivíduos virtuosos comprometidos com a Contrarreforma. O artigo investiga a relação entre o drama jesuítico e a música na Áustria nos séculos XVI e XVII. Para isso, será avaliado o desenvolvimento histórico dos dramas jesuíticos, a importância da música como solução para os desafios do uso do latim, as disputas internas ligadas à incorporação de elementos operísticos no teatro jesuítico e o papel dos compositores germânicos associados à capela imperial vienense na composição da música das produções teatrais elaboradas pelos dramaturgos da Companhia de Jesus.
Tupã: o rap indígena dos Brô MC’s como performance micropolítica
Authors: Brietzke Marta Macedo
Published: September 2023

Este texto aborda uma performance com práticas musicais do grupo Brô MC’s, de rap indígena, em conjunto com a Orquestra Infantil Indígena Ueze Zahran realizada em 2019 no encerramento do XXIV Congresso da Associação Brasileira de Educação Musical. Através de abordagens autoetnográficas, o texto discute e concebe essa performance como micropolítica, segundo as concepções de Suely Rolnik (2019), propondo a necessidade da presença consciente em tais práticas. Enfatiza as ideias de performance conforme abordadas por Schechner e Turner (2006) e adota a concepção de musicar, de Christopher Small (1999), para ampliar as ideias de performance comumente adotadas pela área musical, que se relacionam ao ato de cantar ou tocar um instrumento musical. Sugere também as concepções de escutas de mundo, em alusão às ideias de leituras e pronúncias de mundo de Paulo Freire (2019), associando-a aos conceitos de micropolítica. Propõe-se, assim, a participar de debates antirracistas a partir do universo acadêmico, hegemonicamente identificado como branco.