bluuebunny/crossref_metadata_2025 huggingface dataset:
N-(Sulfamoylbenzoyl)-L-proline Derivatives as Potential Non-β-lactam ESBL Inhibitors: Structure-Based Lead Identification, Medicinal Chemistry and Synergistic Antibacterial Activities
Authors: Liu Xinyu , Dong Shengjie , Ma Yuru , Xu Hu , Zhao Hongxia , Gao Qingzhi
Published: August 2018

Background:

There is an urgent need to develop novel inhibitors against clinically widespread extended-spectrum β-lactamases (ESBLs) to meet the challenges of the ever-evolving threat of antibiotic resistances. Most existing ESBL inhibitors sharing a common chemical feature of β-lactam ring in their molecule, this structural characteristic makes them intrinsically susceptible to enzymatic breakdown by the resistance mechanisms employed by the bacteria.

Objective:

The aim of this study was to screen and discover novel lead compounds by using Lproline as initial scaffold to create a “non-sulfur, non-β-lactam” new chemotypes for potential ESBL inhibitors.

Methods:

Structure-based molecular docking and virtual screening were employed in the novel inhibitor generation process for lead compound screening and SAR analysis. Evaluation of the ESBL inhibitory activity of the lead compounds was performed in combination with three of the most susceptible antibiotics: ceftazidime, meropenem and ampicillin, against thirteen ESBL enzymes including four new CTX-M harboring strains and four KPC-2 producing species.

Results:

L-proline derived (S)-1-(2-sulfamoylbenzoyl)pyrrolidine-2-carboxylic acid (compound 6) as a “non-sulfur, non-β-lactam” and the most potential ESBL inhibitor was identified. Compound 6 possesses ideal anti-resistance activities by reducing MICs of ceftazidime, meropenem and ampicillin by 16-133, 32-133 and 67-267 fold respectiveily. The inhibitory mechanism of 6 with CTX-M, KPC-2 and penicillinase were proposed and probed with molecular docking analysis.

Conclusion:

Given that the simple proline derivative but promising synergistic antibacterial properties of compound 6 augers well for further investigations into its in vivo efficacy.
Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report
Authors: Vikramjeet Singh , Angelika Batta , Nishtha Malik
Published: August 2018

Background:

Fixed drug eruption is a clinical entity occurring at the same site each time the
drug is administered. They are usually found on lips, genitalia, abdomen, and legs but can occur at any
location. The eruptions usually occur within hours of administration of the drug and resolves
spontaneously. Most common drugs causing them include antimicrobials. Fluroquinolones especially
norfloxacin is commonly used in the treatment of gastrointestinal infections. Cutaneous adverse drug
reactions are very rare with norfloxacin.

Case Report:

In this case report, a young female, soon after taking Nofloxacin tablet, developed a
blister with erythema and itching after self treatment for urinary tract infection. It got cured after
stopping the drug and taking treatment from a dermatologist. It resolved as a hyper-pigmented scar. She
experienced a similar episode of drug eruption on the same site when she again self medicated herself
with Norfloxacin for diarrhoea. This time the reaction occurred within few hours and resolved with
hyperpigmentation after medication. She was advised not to indulge in self-treatment in future.
Suspecting association between the drug and the rash was confirmed and a diagnosis of Norfloxacin
induced fixed drug eruption was made.

Conclusion:

Causality assessment by Naranjo’s algorithm revealed a definite relationship between the
cutaneous adverse drug reaction and the offending drug.
Engineered Silver Nanoparticles, A New Nanoweapon Against Cancer
Authors: Ebrahimzadeh Mohammad A. , Tafazoli Alireza , Akhtari Javad , Biparva Pourya , Eslami Shahram
Published: August 2018

New modifications in nanoparticles changed their applications obviously. Green synthesis of
nanoparticles and their biomedical utilizations have been the focus of increasing attention in recent years. Silver
nanoparticles (AgNPs) demonstrated surprising effects and many advantageous features for cancer therapy.
Investigations indicated the anticancer activity of AgNPs in different ways, comprising cell cycle arrest, DNA
damaging and apoptosis, alteration of P53 function, up/down regulation of some important cytokine genes and
so on. But some key inquiries like the ability to control the accidental effects of AgNPs, or encompassing process
for parcels, which reduces the toxicological profile of nanoparticles, still remained. “Green synthesis” of
nanoparticles has been shown to be a kind of approach to resolve the toxicity amounts in a range of 10-18 times.
Using distinctive properties of this approach, i.e. as green synthesized silver nanoparticles (G-AgNPs), in order
to raise potential therapeutic efficacy, even up to two-fold higher than cis-platin, is going to play a crucial role in
cancer treatment and could be considered as a new insight in this field. The current review focuses on the antioxidant
activity of G-AgNPs and potential impacts on cancer cells.
Reversing Multidrug Resistance in Chemo-resistant Human Lung Adenocarcinoma (A549/DOX) Cells by Algerian Propolis Through Direct Inhibiting the P-gp Efflux-pump, G0/G1 Cell Cycle Arrest and Apoptosis Induction
Authors: Kebsa Wided , Lahouel Mesbah , Rouibah Hassiba , Zihlif Malek , Ahram Mamoun , Abu-Irmaileh Bashaer , Mustafa Ebtihal , Al-Ameer Hamzeh J. , Al Shhab Mohammad
Published: August 2018

Background:

Lung cancer is one of the most common malignancies with the highest incidence and
mortality rate worldwide. Multidrug Resistance (MDR) continues to pose a major challenge for the clinicians and
pharmacologists to effectively treat this disease. A new approach using natural substances with moderate or low
cytotoxic properties become a promising hope for reversing multidrug resistance due to pgp- overexpression.

Objective:

This study aims to explore the efficacy of Algerian propolis in reversing multidrug resistance and
sensitizing chemo-resistant lung cancer cells (A549/DOX) to chemotherapy with DOX.

Methods:

Resistant lung adenocarcinoma A549/DOX cell line was developed and used as in vitro model for
MDR. Cell viability, Annexin V-PI apoptosis assay and cell cycle progression were tested to evaluate the reversal
effect of propolis alone or in combination with DOX. Caspases 3, 8 and 9 assays were conducted to determine
the type of apoptotic pathway. To investigate the mechanisms of MDR reversal agents, intracellular accumulation
of DOX and P-gp-pump activity were investigated.

Results:

Our results showed that the obtained chemo-resistant cells were 13-fold more resistant to DOX than the
parental A549 cells. Propolis showed dramatically cell growth inhibition on A549/DOX cells (The IC50 was
50.44± 0.07µg/ml). The killing effect of propolis was due to G0/G1 cell cycle arrest and apoptosis induction.
After 24hours treatment, propolis at 100 µg/ml caused cells accumulation in G0/G1 phase and increased
with 50, 65-fold the percentage of apoptotic population sub-G. Annexin V-PI assay showed that propolis
induces apoptosis with 53.57-fold at 100 µg/ml. It induced intrinsic apoptotic pathway by increasing caspase-3
(22.15-fold) and caspase-9 (16.73-fold) activities. The direct approach to investigate the mechanisms of reversal
agents is to detect the accumulation of P-gp substrates in resistant cells. Our results indicated that resistant cells
poorly accumulated Doxorubicin and rhodamine 123 (7-fold lower) when compared to parental A549 cells,
suggesting that chemo-resistant cells overexpress P-gp which pump DOX out of cells. Propolis inhibited in a
concentration-dependent manner, the pgp efflux-pump, enhancing thereby the intracellular level of DOX with
5.48- fold against 3.33 fold obtained with verapamil, the conventional P-gp inhibitor.

Conclusion:

Taken together, Algerian propolis reverses multidrug resistance in resistant human lung
adenocarcinoma cells through direct inhibiting the transport function of pgp-pump resulting in enhancing intracellular
DOX-accumulation, G0/G1 cell cycle arrest and apoptosis induction. Thus, propolis could be developed
as a chemotherapeutic agent for reversing multidrug resistance.
Critical microRNAs in Lung Cancer: Recent Advances and Potential Applications
Authors: Zarredar Habib , Ansarin Khalil , Baradaran Behzad , Shekari Najibeh , Eyvazi Shirin , Safari Fateme , Farajnia Safar
Published: August 2018

Background:

MicroRNAs (miRNAs) play an important role in the regulation of various genes
involved in cell growth, development and the maintenance of body homeostasis. They are closely linked to
different human diseases, particularly in cancers. Amplification and overexpression of some miRNAs that are
called ‘oncomiRs’ or down-regulation of tumor suppressor miRNAs are associated with genetic alterations that
are sufficient to drive tumorigenesis in humans. Lung cancer is the leading cause of cancer-related deaths worldwide.
The high mortality rate of lung cancer is not changed even with recent advances in cancer treatment.
Several studies demonstrated that miRNAs are involved in the pathogenesis of lung cancer that they negatively
or positively regulate gene and protein expression by acting as oncogenes or tumor suppressors.

Objective:

This article reviewed the current knowledge on the role of miRNAs and their target genes in lung
cancer and discussed the potential use of some miRNAs as novel therapeutic agents in lung cancer.

Method:

Firstly, we collected and summarized all research and review and research articles in databases including
Scopus and PubMed. Then, we used related keywords that are important to lung cancer target therapy and
their diagnostic and prognostic values.

Results:

Based on collected articles and research, recognizing critical microRNA and controlling the expression
of this microRNA by antagonist oligonucleotides like antagomiRs or anti-miRs and microRNA mimicking will
have a remarkable role in treating lung cancer.

Conclusion:

Many research studies have shown that a combination of chemotherapy plus knockdown or
mimicking microRNA is effective and useful in the cancers treatment like lung cancer.
Inoperable Giant Growth Hormone-secreting Pituitary Adenoma: Radiological Aspects, Clinical Management and Pregnancy Outcome
Authors: Dicuonzo Franca , Purciariello Stefano , De Marco Aurora , Guastamacchia Edoardo , Triggiani Vicenzo
Published: August 2018

Background and Objective: Giant pituitary adenomas (GPAs) are benign tumours with a
diameter ≥ 4 cm [1]. They can cause symptoms and signs due to the possible hyper-secretion of one or
more pituitary hormones, and involvement of the surrounding structures whereas the compression of
the pituitary itself can lead to hypopituitarism.

Methods: We report on a young woman with acromegaly due to an inoperable giant GH-secreting
pituitary adenoma extending to right cavernous sinus, right orbital cavity, ethmoid, right maxillary
sinus, sphenoid sinus, clivus and right temporal fossa, in which medical treatment with Octreotide-
LAR was able to promptly relieve headache and bilateral hemianopsia due to optic chiasm involvement,
improve acromegaly symptoms and, over the time, control tumor expansion, improving fertility
and therefore allowing the patient to become pregnant.

Results: Octreotide-LAR therapy was withdrawn during pregnancy and the patient did not experience
complications and gave birth to a healthy son. On magnetic resonance, the size of the tumor at the end
of pregnancy and in the subsequent follow up was not increased.

Conclusion: The history we report, therefore, confirms previous experiences reporting a possible
favourable outcome of pregnancy in patients affected by acromegaly and adds further information
about the behaviour of giant pituitary tumors in patients underwent pregnancy.
Anti-Saccharomyces Cerevisiae as Unusual Antibody in Autoimmune Polyglandular Syndrome Type III: A Case Report
Authors: Gorgel Ahmet , Cankaya Cem , Tecellioglu Mehmet
Published: August 2018

Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are
considered to reflect immune response against increased intestinal permeability due to mucosal damage
are among the serological markers of Crohn’s Disease.

Methods: This microbial seromarker was recently shown to be elevated in several autoimmune disorders
such as celiac disease, autoimmune liver diseases, type 1 diabetes, and Graves’ disease. Despite
that fact, ASCA seropositivity in Autoimmune Polyglandular Syndrome (APS) has never been reported
before.

Results: Herein, we present a 46-year-old woman who has uveitis, autoimmune thyroiditis, and primary
ovarian failure.

Conclusion: Based on the coexistence of these diseases, the patient was diagnosed with APS type III.
Moreover, ASCA seropositivity was detected although she has no overt intestinal disease.
CFD and Optimization Study of Frictional Pressure Drop Through Bends
Authors: Debnath Suman , Banik Anirban , Bandyopadhyay Tarun Kanti , Saha Apu Kumar
Published: August 2018

Background: The non-Newtonian pseudoplastic liquid flow through different types of
the bend is more complicated compared to the simple straight pipe as the bends are associated with
various curve geometry. Bends have wide application in bioengineering, biotechnology and biomedical
such as study biofluids, blood rheology study, the design of medical equipment like
equipment measuring the cholesterol etc.

Method: The papers deal with the estimation of loss coefficient and frictional pressure drop of
Newtonian and non-Newtonian pseudoplastic fluid flow through the different bend of 0.0127 m diameter
pipe geometry using commercially available CFD software fluent 6.3. We revised all patents
relating to the pipe flow through different types of bend. The present study also deals with the
efficient application of Genetic Algorithm (GA) for optimization of frictional pressure drop. Laminar
Non-Newtonian Power law model is used for Sodium Carboxy Methyl Cellulose (SCMC) solution
to solve the continuity and the momentum equations numerically. Generalized input-output
correlation has been developed by Gene Expression Programming (GEP) using Matlab.

Results: The above-mentioned algorithm is used to predict and optimize the pressure drop. It has
been found that, the process exhibit the minimum pressure drop across the bend under optimum
condition (Angle = 133.160, Concentration = 0.2 Kg/m3 and velocity = 0.53 m/s). The effect of
flow rate, bend angle, fluid behaviour on static pressure and pressure drop has also been investigated.

Conclusion: From the study, it can be concluded that the developed GA model has a good agreement
with the CFD model. The software predicted data might be used to solve various industrial
problems and also to design different equipment.
Preparation and Characterization of Large Unilamellar Vesicles Mixed With Trimethylchitosan (TMC): The Effect of Polyelectrolyte Concentration
Authors: Van Der Merwe S.M. , Bouropoulos N. , Katsamenis D.A. , Lampou O.L. , Fatouros D.G.
Published: August 2018

Background:

The effect of different concentrations of the absorption enhancer Trimethyl Chitosan (TMC) to the physicochemical properties of Large Unilamellar Vesicles (LUV) comprised of L-a-Phospahtidyl Choline (PC) were investigated in the current study.

Methods:

The Degree of Quartenization (DQ) of trimethylchitosan was assessed with nuclear magnetic resonance (1H NMR). The vesicles were characterized by means of Dynamic Light Scattering (DLS), ζ-potential, Differential Scanning Calorimetry (DSC) and Contact Angle Goniometry (CAG) measurements.

Results:

The data showed that the surface charge of the PC liposomes was significantly altered as a function of the TMC concentration, giving evidence of presence of the polyelectrolyte to the liposome’s membrane. Varying the concentration of TMC affected the phase Transition Temperature (Tm) of the lipid, verifying the miscibility of the polyelectrolyte with the lipid bilayer. The association of the polymer with the liposomes was related to the amount of the polyelectrolyte present, reflecting changes to the wettability of the dispersion as measured by CAG.

Conclusion:

The results demonstrated that presence of TMC significantly modified the physical properties of liposomes. Such systems might have a potential use for mucosal delivery (e.g. nasal route of administration).
Behavior of Extended End-Plate Steel Beam to Column Connections
Authors: Al Fakih Kamal , Chin Siew Choo , Doh Shu Ing
Published: August 2018

Background:

The main objective of this study is to simulate the behaviour of steel beam-to-column connections using the computer package of Finite Element Analysis (FEA) known as “ABAQUS”.

Objective:

This paper presents the investigations of extended End-Plate connections (EP). A one-model segment is examined under the impact of concentrated load and the exclusive boundary conditions were tested. The analysis of the nonlinear behaviour of the connection is a complicated science and needs to use programs to solve this problem. Experimental works are normally conducted for this type of studies which used more of money, time and effort. Therefore, with the availability of simulation applications, these problems can be addressed.

Results and Conclusion:

The results of the evaluation were compared with the experimental data from the available literature. In this case, nonlinearity materials were used. A sample study on EP connections was carried out using both material and geometric nonlinearities. The comparison of FEA results with corresponding experimental results confirms the correlation and convergence between them.
The Effect of Flat Dual-Cure Stabilizer Occlusal Splint in Pain Relief of Individuals Suffering from Migraine Headaches
Authors: Sahebi Majid , Zeighami Somayeh , Hajimahmoudi Mohammadreza
Published: August 2018

Background:

No study on the effect of dual-cure stabilizer splint without canine ramp in migraine patients is present.

Objective:

This study was conducted to determine the effects of maxillary flat dual-cure stabilizer occlusal splint on severity, frequency and episodes of headaches in individuals suffering from a migraine.

Methods:

In this interventional clinical trial, 30 eligible patients were divided into 2 groups (case and control); each group consisted of 8 men and 7 women. Dual-cure stabilizer splint was made for patients in the case group and they used the adjusted splint 20 hours a day for 6 weeks. The severity, frequency and episodes of migraine attacks before and after using the splint were determined. For grading pain, severity visual analogue scale was used. The data were analyzed usingSPSS20 and Kolmogorov-Smirnov test and paired t-test.

Results:

The severity, frequency, and episodes of migraine attacks before and after using the splint were reduced by 56%, 68%, and 72%, respectively. The reduction was statistically significant (p< 0.05).

Discussion:

Despite the effect of occlusal devices on the migraine disorder is controversial, the most researchers agree that using these appliances can be effective in reducing headache in migraine patients.

Conclusion:

Given the favorable effects of dual-cure stabilizer splint on reducing the severity, frequency and episodes of migraine headaches, the device can be used as an effective alternative therapy besides common pain-relieving methods.
Microbial Infections and Antimicrobial Resistance in Nepal: Current Trends and Recommendations
Authors: Dahal Ram H. , Chaudhary Dhiraj K.
Published: August 2018

Antimicrobial resistance is a life threatening challenges to the world. Most of the well-known antibiotics are currently ineffective to several microbial diseases. Ampicillin, metronidazole, amoxicillin, cotrimoxazole, chloramphenicol, ciprofloxacin, nalidixic acid, gentamicin, and ceftazidime are common antibiotics whose resistance pattern has been elevated in recent years. The rise and dissemination of resistant bacteria has contributed in increasing cases of antimicrobial resistance. Multi-drug Resistant (MDR) organism such asStaphylococcus aureus, Pseudomionas aeruginosa, Escherchia coli, andMycobacterium tuberculosisare principal problems for public health and stakeholders. Globally, issues of antimicrobial resistance are major concern. In the context of Nepal, insufficient surveillance system, lack of appropriate policy, and poor publications regarding the use of antibiotics and its resistance pattern has misled to depict exact scenario of antimicrobial resistance. This mini-review presents current trends of antibiotic use and its resistance pattern in Nepal. In addition, global progression of antibiotic discovery and its resistance has been covered as well. Furthermore, use of antibiotics and possible ways on improvement of effectiveness have been discussed.
Blood Cell Proteomics in Chronic Kidney Disease
Authors: Bonomini Mario , Pieroni Luisa , Ronci Maurizio , Sirolli Vittorio , Urbani Andrea
Published: August 2018

Background:

The uremic syndrome mimes a systemic poisoning with the retention of numerous compounds which are normally removed by the kidney. The study of proteins and peptides, or proteomics, represents an important field of research for the investigation of blood and blood diseases.

Methods and Materials:

We focused our review on the results of proteomic investigations on blood cells of uremic patients with particular regard to the study of red blood cells, platelets, and monocytes.

Results:

In literature there are few, preliminary studies on platelets and monocytes while the knowledge on uremic erythrocytes is much wider. Proteomic investigations showed that erythrocyte membrane proteome of uremic patients, differs significantly from the proteome of healthy subjects, being characterized by an extensive remodeling which may influence visco-elastic properties of RBC such as deformability and involve diverse molecular pathways driving red blood cell signaling and removal.

Conclusion:

Proteomic technologies emerged as a useful tool in defining and characterizing both physiological and disease processes being able, among others, to give important insights into uremic anemia.
MicroRNA155 Expression in Relation to BDCAF Scored Behçet's Disease in an Egyptian Patients' Sample
Authors: Hassouna Sally S. , Tayel Manal Y. , ElKaffash Dalal M. , Abdelhady Ahmed M. , Elsayed Eman H.
Published: August 2018

Objective:

To discover the possibility of using microRNA155 (miRNA155) expression level as a biomarker of Behçet's Disease (BD) activity or remission.

Methods:

Thirty BD patients’ white blood cells (WBCs) miRNA155 expression was measured and compared to WBCs miRNA155 expression in 15 healthy subjects. Assessment of disease activity was done using Behçet's Disease Current Activity Form (BDCAF).

Results:

miRNA155 expression significantly decreases with the increase of BD activity scored by BDCAF.

Conclusion:

Increased miRNA155 may be used as a biomarker of BD remission and thus in the disease follow up. There could be a prospect of treating the diseaseviamicroRNA 155 effect enhancement.
Treatment of Type Two Slap Lesion With Anatomic Suture Anchor Repair Without Biceps Tenotomy Or Tenodesis
Authors: Prodromos Chadwick C. , Finkle Susan , Dawes Alexander , Baik Ji Young
Published: August 2018

Background:

Poor results after repair of type 2 SLAP tears are relatively common and some have reported better results after biceps tenodesis or tenotomy than repair. In addition, some believe that the long head of the biceps is expendable. Therefore, many now favor biceps tenotomy or tenodesis over biceps anchor repair either in all patients or in older patients, reserving SLAP lesion repair only for young athletes.

Hypothesis:

We hypothesized that repair of the biceps anchor of the labrum would be effective in all patients regardless of age provided that care was taken not to overtighten the labrum and that rotator cuff pain as the primary pain generator had been ruled out.

Methods:

All patients with type 2 SLAP lesion repair by the senior author since he began repairing them with suture anchors were prospectively evaluated. Patients with more than one other concomitant procedure, simultaneous rotator cuff repair or worker’s compensation status were excluded.

Results:

77% of patients were available for minimum two year followup. No patient had subsequent surgery or manipulation under anesthesis as a result of their SLAP repair. Standardized shoulder test score increased by 4 points. Mean SANE score decreased from 53 pre-op to 14 post-op. Results were the same in those over versus under 40 years of age.

Conclusion:

Anatomic repair of Type 2 SLAP lesions at the biceps anchor without biceps tenodesis or tenotomy can produce good results in patients of all ages.
Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?
Authors: Amini Peyman , Mirtavoos-Mahyari Hanifeh , Motevaseli Elahe , Shabeeb Dheyauldeen , Musa Ahmed Eleojo , Cheki Mohsen , Farhood Bagher , Yahyapour Rasoul , Shirazi Alireza , Goushbolagh Nouraddin Abdi , Najafi Masoud
Published: August 2018

Background:

Melatonin is a natural body product that has shown potent antioxidant property against various toxic agents. For more than two decades, the abilities of melatonin as a potent radioprotector against toxic effects of ionizing radiation (IR) have been proved. However, in the recent years, several studies have been conducted to illustrate how melatonin protects normal cells against IR. Studies proposed that melatonin is able to directly neutralize free radicals produced by IR, leading to the production of some low toxic products.

Discussion:

Moreover, melatonin affects several signaling pathways, such as inflammatory responses, antioxidant defense, DNA repair response enzymes, pro-oxidant enzymes etc. Animal studies have confirmed that melatonin is able to alleviate radiation-induced cell death via inhibiting pro-apoptosis and upregulation of anti-apoptosis genes. These properties are very interesting for clinical radiotherapy applications, as well as mitigation of radiation injury in a possible radiation disaster. An interesting property of melatonin is mitochondrial ROS targeting that has been proposed as a strategy for mitigating effects in radiosensitive organs, such as bone marrow, gastrointestinal system and lungs. However, there is a need to prove the mitigatory effects of melatonin in experimental studies.

Conclusion:

In this review, we aim to clarify the molecular mechanisms of radioprotective effects of melatonin, as well as possible applications as a radiation countermeasure in accidental exposure or nuclear/radiological disasters.
Type 2 Diabetes Study, Introduction and Perspective
Authors: Lu Da-Yong , Che Jin-Yu , Yarla Nagendra Sastry , Zhu Hong , Lu Ting-Ren , Xu Bin , Putta Swathi
Published: August 2018

Background:

The prevalence of Type 2 Diabetes Mellitus (T2DM) continues to rise globally. The T2DM prevalence is not only in developing countries, but also in developed countries now. Correspondingly, the therapeutics of T2DM calls for a change (higher efficiency) due to growing number of patients and increasing economic burdens globally. Entering into this millennium, both piecemeal pathways (idea driven) and exponential growth of human genomic study are developing quickly. Genetypic-phenotypic translation, modern diagnostics, pharmacology, drug developments, traditional Chinese medicine, personalized medicine and so on are promising disciplines for this change. The clinical anti-diabetic therapeutics, pathogenesis, drug development pipelines are especially highlighted.

Conclusion:

In summary, a general landscape and principle of T2DM is provided.
Inventaire archéologique – Fiche Nr 236
Authors: Collumbien Hugo
Published: August 2018

Op 28 december 1901 stelde E. Coppieters Stochove in de rubriek “Goudsmederij - St-Michielskerk, schatten - XVIIe eeuw (1617)” in het Frans een fiche op over Zilveren Kruisbeelden van de Broederschap van het Heilig Kruis
Inventaire Archéologique - Fiche nr 237: Het Vaandel van de Onvrije Schippers.
Authors: Collumbien Hugo
Published: August 2018

Op 1 februari 1902 stelde Victor De Muynck in de rubriek "Schilderijen - Oudheidkundig Museum, n° 787 - XVIIIe eeuw (1701)" in het Frans een fiche op over“Het Vaandel van de Onvrije Schippers”
De afkomst van Jacob Van Caneghem
Authors: Ervynck Gontran
Published: August 2018

De figuur van Jacob van Caneghem, weldoener van het Blindenhuis aan de Coupure, werd aan de vergetelheid ontrukt dank zij een recent artikel in het tijdschrift (41e jrg. nr.6 (2012) blz.458-473). Er blijkt nochtans enige verwarring te bestaan betreffende zijn afkomst, hij was geen geboren Gentenaar. Dit stelt geen groot probleem, onze archieven, i.h.b. het Stadsarchief in de Zwarte Doos, zijn rijk genoeg om alle desbetreffende onzekerheden uit de wereld te helpen.
Anne de Laval (Delavaux-De La Vaux). Lomme 1625 - Gent 1671
Authors: Vande Casteele Lieve
Published: August 2018

Het wonderbare leven van Anne de Laval deed een aantal geschiedschrijvers naar de pen grijpen. In 1625 in Lomme bij Rijsel als boerenmeisje geboren, zou zij na een heroïsche militaire carrière in het cisterciënzerinnenklooster bij Marquette-lez-Lille ingetreden zijn. Van daaruit zou ze naar het Gentse Bijlokeklooster zijn overgeplaatst, waar ze in 1671 overleed.
Verering van de vrouwelijke “Baardheilige” Wilgefortis om en rond de Sint-Baafsabdij.
Authors: Mattens Danny
Published: August 2018

Het vroegste spoor van de verering van de vrouwelijke ‘baardheilige’ Wilgefortis, alias Sint-Ontcommere of Oncomena in Europa zijn te vinden in het graafschap Vlaanderen, meer bepaald in Gentse mannenkloosters. Dit haast onwaarschijnlijke verhaal van middeleeuwse mystiek wordt uit de doeken gedaan in het volkskundige tijdschrift Van Mensen & Dingen (zie ojs), waar deze, zo goed als vergeten, mythische figuur meer uitgebreid belicht wordt1. In deze bijdrage gaan we in het bijzonder in op de verering die verband hield met de Sint-Baafsabdij en haar godshuiskapel aan de verdwenen Spitaalpoort (Dampoort buurt).
Veneziana, Geldmunt.
Authors: Van Ryssel Daniël
Published: August 2018

De Geldmunt vormt de westelijke grenslijn van de wijk het Patershol. Ze ligt in het verlengde van de Lange Steenstraat, waar ze aanvankelijk deel van uitmaakte, en leidt naar het Gravensteen, waar ze uitmondt op het St.-Veeleplein. De straat ontleent haar naam aan het Muntgebouw van de graven van Vlaanderen, dat in de straat gelegen was, palend aan de N-O zijde van het Gravensteen en recht tegenover de kapel van St. Elooi, patroon van het ambacht van de smeden.
Cornelis Meyer (Gent ? - Gent omstreeks 1734)
Authors: Van Ryssel Daniël
Published: August 2018

Cornelis Meyer was boekdrukker van beroep en woonde op de Hoogpoort in “‘t Gecroond Sweerd” samen met zijn broer Jan. Hij had als kenspreuk: “Altijd bezig”. Samen met Jakob Heye is hij een van de belangrijkste herstellers en werkzaamste leden van de rederijkerskamer De Fonteine.
Aan de Gentenaren overleden in Kongo vóór 1908
Authors: Van Cleven Pierre
Published: August 2018

Verscholen achter hagen en bomen aan het uiteinde van het Zuidpark in Gent (officieel Koning Albertpark), zijn twee vrijwel onbekende monumenten te vinden. Het ene stelt Leopold II voor met als opschrift “Aan de stad Gent, de Int. Jaarbeurs der Vlaanderen, 10deVerjaring 1955”. Het andere is een horizontaal liggende stervormige steen met tussen de vijf armen van de ster een aantal namen en data. Het opschrift luidt “Aan de Gentenaars overleden in Kongo vóór 1908 - Au Gantois morts au Congo avant 1908”
Inventaire Archéologique - Fiche nr 267 : Doos met Heilige oliën.
Authors: Collumbien Hugo
Published: August 2018

Op 25 Oktober 1902 stelde E. Coppieters Stochove in de rubriek “Goudsmidswerk - Akkergemkerk, Schatten - XVIIe eeuw - 1681” in het Frans een fiche op.
Emma Kraft, een Deense schrijfster op bezoek in Gent.
Authors: Van de Maele Romain John
Published: August 2018

In januari 1895 werd Virginie Loveling benaderd door de Deense schrijfster en vertaalster Emma Kraft (1844-1925). De Deense schrijfster vroeg aan Virginie Loveling of ze het verhaal ‘Po en Paoletto’ van Rosalie in het Deens mocht vertalen.
Inventaire Archéologique - Fiche nr 272. : De Kruisboog met houten boog van het Sint-Jorisgilde.
Authors: Collumbien Hugo
Published: August 2018

Op 21 September 1902 stelde Alfons Van Werveke in de rubriek “Wapens - Oudheidkundig Museum - XVIe eeuw” in het Nederlands een fiche op.
Vlaanderenstraat, Gent
Authors: Van Ryssel Daniël
Published: August 2018

In het begin van de 19e eeuw werden de moerassige Muinkmeersen drooggelegd. De bouw van het station aan het Graaf van Vlaanderenplein (1837) bracht dit gebied tot leven. Er ontbrak echter een vlotte verbinding van het station met de oude binnenstad.
Theodore Schellinck (Gent 1797 - Gent 1867).
Authors: Van Ryssel Daniël
Published: August 2018

Théodore Adrien Liévin Schellinck is geboren in 1797 te Gent op het Steendam. Zijn vader Jacques François was verkoper van kleuren, later politiecommissaris; zijn moeder Anna Tollens, was verwant aan de Nederlandse dichter Hendrik Tollens (1780-1856). In 1821 woonde hij Kortrijksepoortstraat 38. In 1824 huwde hij met Paulina Debleecker en stond hij ingeschreven als onderwijzer. Persoonlijk fortuin bezat hij niet, maar hij had wel een opleiding genoten en bezat een eruditie die zijn tijdgenoten journalisten niet bezaten.
Karel II.
Authors: Kluyskens Pierre
Published: August 2018

Op de vreemdeling die in de lentedagen van 1666, langs de Brugsevaart, te Gent aankwam, goed geluimd en opgemonterd door de heerlijke spijzen en dranken die de faam van de beruchte Bargie of trekschuit, ver over ‘s lands grenzen hadden verkond, moet onze stad wel een allerbeste indruk hebben gemaakt.
De platen van Terplaten
Authors: Gelaude Frank , Devriese Luc
Published: August 2018

Wat betekent die naam? Welke platen waren er bij Ter Platen te zien? Volgens de meeste auteurs waren dit zandbanken of slijkplaten in een rivier, die bij lage waterstanden in de zomer bloot kwamen te liggen.
Lisbeth Aerens-Verwest
Authors: Van Ryssel Daniël
Published: August 2018

Elise Barbe Verwest is geboren te Gent in 1885 op de Bijlokevest 21. Ze was de dochter van schilder Jean Hippoliet en broer van kunstschilder Jules Benoit Verwest. De familie Verwest, afkomstig uit Goes (NL) vestigde zich met Jacobus in 1805 te Gent (in 1834 spoorloos verdwenen en nooit teruggevonden) en heeft gedurende twee eeuwen met iedere generatie verscheidene schilders en kunstschilders opgeleverd.
Reilen en zeilen van de stad in 1920. Uit de gemeenteraad
Authors: Brysse Adrien
Published: August 2018

O.a. over de Stedelijke Koedienst, zondagsschool voor mannen, ontuchthuizen, Gentse Feesten, onlusten, nieuwe straatbenamingen enz.
Een crochet, een zangcrochet, wat was dat?
Authors: Devogele Marianne
Published: August 2018

Net als nu waren in de vorige eeuw zangwedstrijden met kandidaat - vedetten in allerhande maten en gewichten populair. Iedereen beroemd! Ook toen. Alleen speelden de competities zich meestal niet af op het TV scherm, maar voor een publiek in grote of kleine zalen en zaaltjes al of niet met radio opname... en ze werden crochet of zangcrochet genoemd.
Het Meerhemkanaal en zijn brugjes.
Authors: Brysse Adrien , Gelaude Frank , Devriese Luc
Published: August 2018

Het Meerhem was waarschijnlijk een gekanaliseerde oude Leiearm die onderdeel werd van het oudste kanaal in het Gentse: de Schipgracht. Die ‘gracht’ met een opvallend bochtig verloop verbond de stad met het dichte waterlopenstelsel in het noorden van het graafschap. Langs deze waterweg werden bakstenen en daktegels (tichels) uit Stekene en vooral turf aangevoerd uit de veengebieden in Vier Ambachten en Zeeuws-Vlaanderen.
Wat als... er in Gent geen stuwen en sluizen zouden zijn.
Authors: Gelaude Frank
Published: August 2018

In het verslag in dit GT nummer over de laatste dagen van de Duitse bezetting is er sprake van het ondermijnen en opblazen van de Gentse bruggen en stuwen. Daarin lezen we onder andere: ‘Het opblazen van die sluizen zou zware gevolgen hebben. Bij hoog water zou het tot overstromingen komen en bij lage tij zou de stad niet minder geteisterd worden door het leeglopen van haar waterbekkens.’ Wat is daar van aan?
Rokerelsstraat: rode ‘kerels’ (mantels), dat wel... maar geen kulders
Authors: Doesselaere Hans , Devriese Luc
Published: August 2018

De Rokerelsstraat, een straatje tussen de Martelaarslaan en de Bijlokevest, dat kennen naast buurtbewoners vrijwel enkel de al iets oudere liefhebbers van streekbiertjes (afb. 1). Het was immers de eerste vestigingsplaats van de Hopduvel.
Straffe toeren (1815-1819).
Authors: Devriese Luc
Published: August 2018

Gesprokkeld en vertaald uit de Mémorial de la Ville de Gand 1790 -1830 van Prosper Claeys, Gent, 1902. Met hier en daar een klein kommentaartje ter verduidelijking.
Bouwaanvragen als spiegels van het dagelijks leven in Gent tijdens de vroegmoderne periode (1671-1795).
Authors: De Doncker Tim
Published: August 2018

Het Gentse stadsarchief herbergt een prachtige collectie van meer dan zesduizend bouwaanvragen of -vergunningen uit de periode 1671-1795. Deze verzoekschriften werden opgesteld wanneer een bouwheer een verbouwing of een nieuwbouw wenste uit te voeren.
Vier onderstations elektriciteit
Authors: Van Ryssel Daniël
Published: August 2018

In 1903 richtten twee privémaatschappijen, de AEG en de Union Electrique in Gent in de Bomastraat een elektrische centrale op die zou uitgebaat worden ‘in regie’ met de Stad Gent. Daaraan dienden onderstations te worden verbonden die de elektriciteit verder moesten transporteren en omvormen voor industrieel en huishoudelijk gebruik.
Institutions on Public Open Space Governance
Authors: Ling Gabriel H.T. , Hob Chin Siong , Mohd Ali Hishamuddin
Published: August 2018

Meagre discussion on the institutional property-rights structure essence has rudimentarily determined the POS governance and its quality. Thus, two objectives are highlighted; (i) to examine Sabah's current practice (rights distribution) in urban-rural POS governance and (ii) to explore the POS social dilemmas that tied in with such institution. Reviews of interdisciplinary analytic perspectives, content analysis on documents and semi-structured interviews were performed. The practice with diverse property-rights structure is indicatively perceived as property-rights tragedies' which ensue in sub-optimal POS and quality of life issues. Therefore, re-engineering of POS market via dynamic property-rights re-assignment is postulated as the panacea for improved well-being.
The Mechanisation and Automation of the IBS Construction Approach in Malaysia
Authors: Kamaruddin Siti Syariazulfa , Mohammad Mohammad Fadhil , Mahbub Rohana , Ahmad Khairani
Published: August 2018

The objective of the main research is to investigate the current state of implementation of mechanisation and automation in the Industrialised Building System (IBS). The aim of this paper, however, is to provide an overview of the implementation of mechanisation and automation in the IBS construction approach. Questionnaire surveys and semi-structured interviews were conducted to collect the viewpoints among contractors and manufacturers of IBS to ensure the richness of the data collected. The results illustrated that although most respondents agreed on most critical issues in the implementation of mechanisation and automation, they were not ready to move forward. These responses were quite consistent across the professions.
The Shaping of Knowledge: Communication of meaning through museum exhibition design
Authors: Ahmad Shamsidar , Abbas Mohamed Yusoff , Mohd. Taib Mohd. Zafrullah , Masri Mawar
Published: August 2018

The primary objective of museum management in the shaping of knowledge can be achieved by a communication of meaning through quality displays of the permanent collection or temporary exhibitions, the specimens of a continent or the interactive apparatus of science. This paper looks at research derived primarily from museum scholars and experts with academics working in the field of visitor studies towards developing exhibits that facilitated visitor learning. These findings recast the approach in order to offer an integrated framework for visitor behaviour that has implications for service management of the service encounter at the museum in Malaysia.
Traditional Neighborhood Adaptive Reuse in the Old City Sana'a, Yemen
Authors: Ahmed Haidar Laila , Talib Anuar
Published: August 2018

The study aims to identify the current conditions of the traditional neighbourhood (Hara) environment of Sana'a old city and to evaluate the outcomes of adaptive reuse. A case study of Hara Al-Abhar was made with the following instruments: On-site spatial observation and measurements and in-depth structured interviews. The study revealed the enhancement of income to house owners and the revival of traditional handicrafts. The disadvantage is that it disturbs the resident's privacy with the increment of vehicular accessibility and previously open public spaces and streets becoming parking spaces. This led the womenfolk to retreat into their houses.
Participación, vida democrática y sentido de pertenencia según tipo de establecimiento educativo en Chile
Authors: Castillo Riquelme Victor , Rodríguez Garcés Carlos , Escalona Burgos Juan
Published: August 2018

Este artículo analiza, a través de bases de datos oficiales del Ministerio de Educación de Chile,  la Participación y Formación Ciudadana como criterio de calidad educativa, comparando índices y estadísticas según establecimiento al que concurren los estudiantes  de  8°  básico  en  Chile.  Los  hallazgos  dan  cuenta  de  diferencias estadísticamente significativas en las dimensiones de Vida Democrática, Sentido de Pertenencia y Participación. Si bien Participación y Formación Ciudadana constituyen uno de los objetivos fundamentales de la escuela, su manifestación no escapa a la dinámica de reproducción social instalada en el sistema educativo. Resulta preocupante que el fortalecimiento de la democracia y del comportamiento cívico de los estudiantes esté circunscrito al tipo de establecimiento que asisten.
Los artesanos de la enseñanza. Acerca de la formación de maestros con oficio , de Andrea Alliaud
Authors: Ardusso Melina Luján
Published: August 2018

Andrea Alliaud, doctora en Ciencias de la Educación por la Universidad de Buenos Aires, invita en este libro a pensar la docencia como una práctica artesanal. Ofrece una obra pedagógica singular, expresión de una trama en la que intervienen aportes teóricos y saberes prácticos actuales y sustantivos. Tal como lo expresa el resumen en la contratapa: “convoca y desafía a maestros, profesores y formadores (…) a enseñar y seguir enseñando, más allá de los tiempos y circunstancias, y a hacerlo cada vez mejor”.
Transición y sentido identitario de la formación académica en estudiantes de secundaria de origen rural. Una aproximación desde el sur de Chile
Authors: ´Álvarez-Espinosa Alejandro , Vera-Bachmann Daniela , Almonacid González Paula , Coderch García Millaray , Hagen Hernández Francisca , Puschel Cárdenas Francisca
Published: August 2018

Desde la tradición histórico-cultural, esta investigación explora los sentidos que otorgan a su actividad académica seis jóvenes de procedencia rural que cursan estudios secundarios en liceos urbanos de dos provincias del sur de Chile. Se utilizó la entrevista narrativa autobiográfica y el modelo de análisis de relatos de práctica propuesto por Gallardo y Sebastián (2012). Los resultados muestran la presencia de dos estructuras narrativas: heroica, en que un destinador impulsa al protagonista a obtener una recompensa, y de penitencia, donde el protagonista sufre temporalmente un destino indeseado. La primera se asocia a una articulación de sentido fuerte y alto nivel de agencia de los jóvenes respecto de su elección vocacional; la segunda, a una articulación de sentido débil y escaso nivel de agencia en la elección vocacional.
Análisis de las contribuciones de un programa social a la trayectoria universitaria de jóvenes en situación de vulnerabilidad social.
Authors: Mayer Liliana , Cerezo Leticia
Published: August 2018

Este artículo tiene como propósito exponer algunos de los resultados de la evaluación de un programa, implementado en Argentina, que busca promover la inclusión y permanencia universitaria de jóvenes en situación de vulnerabilidad social mediante el despliegue de dos recursos: estipendio mensual y tutorías universitarias. Para ello, se analizan las percepciones de los estudiantes respecto de las principales implicancias del programa en sus trayectorias universitarias, con foco en los factores que habilitan su permanencia y continuidad en las instituciones. La investigación es principalmente cualitativa; combina grupos focales con entrevistas en profundidad y se complementa con encuestas autoadministradas. Se observa que el programa y los recursos que pone en juego realizan interesantes aportes para la inclusión y permanencia de los jóvenes en el sistema de educación superior.
Interações e práticas no Facebook
Authors: Primo Alex , Valiati Vanessa , Lupinacci Ludmila , Barros Laura
Published: August 2018

Este artigo discute as transformações trazidas pela comunicação mediada por computadores, e mais especificamente os serviços de redes sociais na internet, para a expressão subjetiva, o relato cotidiano e a escrita de si. Mais tarde, a partir de resultados quantitativos obtidos através de uma survey que alcançou 810 respondentes, discute-se os usos mais prevalentes do Facebook: manter-se informado sobre temas atuais; divertir-se com piadas, vídeos e fotos engraçados; participar de campanhas de conscientização; falar sobre trabalho e saber do crescimento profissional de outros; e saber o que amigos, inimigos e desafetos estão fazendo.
O SILÊNCIO NA SALA DE AULA
Authors: Antunes Maria Luisa Ribeiro Amorim , Modl Fernanda De Castro
Published: August 2018

Este trabalho tem como objetivo mapear e entender, através de uma pesquisa-ação, significados do e para o silêncio na sala de aula, bem como suas inter-relações com a participação e questões relacionadas à (re)construção identitária dos discentes. Além de resenhar a noção de silêncio na perspectiva da Análise do Discurso Francesa (ADF), compreendendo-a como uma discursividade do cotidiano interacional da sala de aula, buscando o aperfeiçoamento da prática pedagógica a partir das noções de que o silêncio é o princípio de toda enunciação e de silenciamento como processo de censura para identificar a ideia de participação em sala de aula. Os resultados obtidos via instrumento questionário apontam para os fazeres, dizeres e silenciares na interação didática dando uma maior compreensão daquilo que parece orientar os comportamentos dos sujeitos alunos.
HISTÓRIA, MEMÓRIA, EDUCAÇÃO E SERTÕES NO JORNAL "A PENNA"
Authors: Teixeira Byron De Castro Muniz , Sousa Maria Aparecida Silva de
Published: August 2018

O presente trabalho descritivo de cunho quantitativo visa empreender reflexões acerca da difusão cultural realizada a partir do periódico A Penna (1897-1930), considerando posicionamentos de João Antônio dos Santos Gumes, proprietário do periódico. Busca-se, portanto, evidenciar a sua importância como difusor da cultura entre os habitantes de uma cidade sertaneja em fins do século XIX. Desse modo, abordamos como seus posicionamentos no periódico possibilitaram criar um lugar de memória sobre o passado desta localidade, ao mesmo tempo em que afirmava sua perspectiva de futuro sobre os rumos da República que acabava de ser instituída.
DISCRIMINATION INTEGRATED DEVELOPMENTAL SUPERVISION MODEL
Authors: Dambo Neffisatu
Published: August 2018

Counselor supervision is important for the development of future counselors and for client safety.  Supervision is a process that provides monitoring, training, consultation, and feedback to help with counselors’ development, skill, and competencies.  Therefore, the purpose of this manuscript is to present the Discrimination Integrated Developmental Supervision Model (DIDSM), which is an integration of Bernard’s (1997) Discrimination process model and Stoltenberg and Delworth’s (1987) Integrated Developmental Model.  The author will also discuss how the following DIDSM tenets are essential to counselor supervision: (a) the supervisory relationship, (b) modeling, (c) feedback, and (d) the awareness of self and others.