bluuebunny/crossref_metadata_2025 huggingface dataset:
Residual-Shuffle Network with Spatial Pyramid Pooling Module for COVID-19 Screening
Authors: Zulkifley Mohd Asyraf , Abdani Siti Raihanah , Zulkifley Nuraisyah Hani , Shahrimin Mohamad Ibrani
Published: August 2021

Since the start of the COVID-19 pandemic at the end of 2019, more than 170 million patients have been infected with the virus that has resulted in more than 3.8 million deaths all over the world. This disease is easily spreadable from one person to another even with minimal contact, even more for the latest mutations that are more deadly than its predecessor. Hence, COVID-19 needs to be diagnosed as early as possible to minimize the risk of spreading among the community. However, the laboratory results on the approved diagnosis method by the World Health Organization, the reverse transcription-polymerase chain reaction test, takes around a day to be processed, where a longer period is observed in the developing countries. Therefore, a fast screening method that is based on existing facilities should be developed to complement this diagnosis test, so that a suspected patient can be isolated in a quarantine center. In line with this motivation, deep learning techniques were explored to provide an automated COVID-19 screening system based on X-ray imaging. This imaging modality is chosen because of its low-cost procedures that are widely available even in many small clinics. A new convolutional neural network (CNN) model is proposed instead of utilizing pre-trained networks of the existing models. The proposed network, Residual-Shuffle-Net, comprises four stacks of the residual-shuffle unit followed by a spatial pyramid pooling (SPP) unit. The architecture of the residual-shuffle unit follows an hourglass design with reduced convolution filter size in the middle layer, where a shuffle operation is performed right after the split branches have been concatenated back. Shuffle operation forces the network to learn multiple sets of features relationship across various channels instead of a set of global features. The SPP unit, which is placed at the end of the network, allows the model to learn multi-scale features that are crucial to distinguish between the COVID-19 and other types of pneumonia cases. The proposed network is benchmarked with 12 other state-of-the-art CNN models that have been designed and tuned specially for COVID-19 detection. The experimental results show that the Residual-Shuffle-Net produced the best performance in terms of accuracy and specificity metrics with 0.97390 and 0.98695, respectively. The model is also considered as a lightweight model with slightly more than 2 million parameters, which makes it suitable for mobile-based applications. For future work, an attention mechanism can be integrated to target certain regions of interest in the X-ray images that are deemed to be more informative for COVID-19 diagnosis.
Computer-Aided Detection (CADe) System with Optical Coherent Tomography for Melanin Morphology Quantification in Melasma Patients
Authors: Chen I-Ling , Wang Yen-Jen , Chang Chang-Cheng , Wu Yu-Hung , Lu Chih-Wei , Shen Jia-Wei , Huang Ling , Lin Bor-Shyh , Chiang Hsiu-Mei
Published: August 2021

Dark skin-type individuals have a greater tendency to have pigmentary disorders, among which melasma is especially refractory to treat and often recurs. Objective measurement of melanin amount helps evaluate the treatment response of pigmentary disorders. However, naked-eye evaluation is subjective to weariness and bias. We used a cellular resolution full-field optical coherence tomography (FF-OCT) to assess melanin features of melasma lesions and perilesional skin on the cheeks of eight Asian patients. A computer-aided detection (CADe) system is proposed to mark and quantify melanin. This system combines spatial compounding-based denoising convolutional neural networks (SC-DnCNN), and through image processing techniques, various types of melanin features, including area, distribution, intensity, and shape, can be extracted. Through evaluations of the image differences between the lesion and perilesional skin, a distribution-based feature of confetti melanin without layering, two distribution-based features of confetti melanin in stratum spinosum, and a distribution-based feature of grain melanin at the dermal–epidermal junction, statistically significant findings were achieved (p-values = 0.0402, 0.0032, 0.0312, and 0.0426, respectively). FF-OCT enables the real-time observation of melanin features, and the CADe system with SC-DnCNN was a precise and objective tool with which to interpret the area, distribution, intensity, and shape of melanin on FF-OCT images.
Passive Tracking of Multiple Underwater Targets in Incomplete Detection and Clutter Environment
Authors: Li Xiaohua , Lu Bo , Ali Wasiq , Jin Haiyan
Published: August 2021

A major advantage of the use of passive sonar in the tracking multiple underwater targets is that they can be kept covert, which reduces the risk of being attacked. However, the nonlinearity of the passive Doppler and bearing measurements, the range unobservability problem, and the complexity of data association between measurements and targets make the problem of underwater passive multiple target tracking challenging. To deal with these problems, the cardinalized probability hypothesis density (CPHD) recursion, which is based on Bayesian information theory, is developed to handle the data association uncertainty, and to acquire existing targets’ numbers and states (e.g., position and velocity). The key idea of the CPHD recursion is to simultaneously estimate the targets’ intensity and the probability distribution of the number of targets. The CPHD recursion is the first moment approximation of the Bayesian multiple targets filter, which avoids the data association procedure between the targets and measurements including clutter. The Bayesian-filter-based extended Kalman filter (EKF) is applied to deal with the nonlinear bearing and Doppler measurements. The experimental results show that the EKF-based CPHD recursion works well in the underwater passive multiple target tracking system in cluttered and noisy environments.
A Fuzzy Based Handover Decision Scheme for Mobile Devices Using Predictive Model
Authors: Gupta Amit Kumar , Goel Vikas , Garg Ruchi Rani , Thirupurasundari Dasarada Rajagopalan , Verma Ankit , Sain Mangal
Published: August 2021

Handover usually deals with the mobility of the end users in a mobile network to assure about the ongoing session of a user. It is observed that frequent handover results in call dropping due to latency. In order to overcome this issue, a fuzzy based handover decision scheme for mobile devices using a predictive model is proposed. First, an MFNN (Multi-layer Feed Forward Network) is used to determine the next cell of the user along with best hand off time. To obtain the best access network, multiple-attribute Access Network Selection Function (ANSF) is used. The fuzzy rule is applied by considering the parameter data rate, reliability, signal strength, battery power and mobility as input and the output obtained is the optimal network. The proposed scheme selects the best access network and enhances the quality of services.
Enhanced Summer Planting Survival of Japanese Larch Container-Grown Seedlings
Authors: Harayama Hisanori , Tobita Hiroyuki , Kitao Mitsutoshi , Kon Hirokazu , Ishizuka Wataru , Kuromaru Makoto , Kita Kazuhito
Published: August 2021

A previous study revealed low survival rates for Japanese larch (Larix kaempferi) summer-planted seedlings grown in Hiko-V-120 containers. This study examines nursery practices that could potentially prevent deterioration of the seedling water balance after planting to improve the survival rate of this species, which has a low drought tolerance. During summer planting, we tested (1) drought hardening or high-potassium fertilization for two months before planting, (2) antitranspirant or topping treatment at planting, and (3) the use of the JFA-150 container with a larger capacity and lower growing density than the Hiko-V-120 container. Drought hardening increased seedling drought tolerance because of the low leaf:root ratio, due to lower leaf mass production, resulting in increased survival from 74% to 93% in Hiko-V-120 containers. When JFA-150 containers were used, the leaf:root ratio was lower because of higher root mass, resulting in an increase in survival to 87%, with the highest survival of 97% when combined with drought hardening. The application of antitranspirant increased survival to over 90%, whereas topping did not, probably because of severer competition from weeds. High-potassium fertilization did not affect seedling traits or survival. For better survival of summer-planted container-grown Japanese larch seedlings, it is recommended that they be grown in containers providing sufficient cell volume and density for root growth while the seedlings are in the nursery and that irrigation be withheld for two months before planting. In addition, to obtain higher survival, an antitranspirant can be applied at planting at a cost.
Two-Layer Reversible Data Hiding for VQ-Compressed Images Based on De-Clustering and Indicator-Free Search-Order Coding
Authors: Chang Chin-Chen , Chang Jui-Feng , Kao Wei-Jiun , Horng Ji-Hwei
Published: August 2021

During transmission of digital images, secret messages can be embedded using data hiding techniques. Such techniques can transfer private secrets without drawing the attention of eavesdroppers. To reduce the amount of transmitted data, image compression methods are widely applied. Hiding secret data in compressed images is a hot issue recently. In this paper, we apply the de-clustering concept and the indicator-free search-order coding (IFSOC) technique to hide information into vector quantization (VQ) compressed images. Experimental results show that the proposed two-layer reversible data hiding scheme for IFSOC-encoded VQ index table can hide a large amount of secret data among state-of-the-art methods with a relatively lower bit rate and high security.
Cross-Project Defect Prediction Method Based on Manifold Feature Transformation
Authors: Zhao Yu , Zhu Yi , Yu Qiao , Chen Xiaoying
Published: August 2021

Traditional research methods in software defect prediction use part of the data in the same project to train the defect prediction model and predict the defect label of the remaining part of the data. However, in the practical realm of software development, the software project that needs to be predicted is generally a brand new software project, and there is not enough labeled data to build a defect prediction model; therefore, traditional methods are no longer applicable. Cross-project defect prediction uses the labeled data of the same type of project similar to the target project to build the defect prediction model, so as to solve the problem of data loss in traditional methods. However, the difference in data distribution between the same type of project and the target project reduces the performance of defect prediction. To solve this problem, this paper proposes a cross-project defect prediction method based on manifold feature transformation. This method transforms the original feature space of the project into a manifold space, then reduces the difference in data distribution of the transformed source project and the transformed target project in the manifold space, and finally uses the transformed source project to train a naive Bayes prediction model with better performance. A comparative experiment was carried out using the Relink dataset and the AEEEM dataset. The experimental results show that compared with the benchmark method and several cross-project defect prediction methods, the proposed method effectively reduces the difference in data distribution between the source project and the target project, and obtains a higher F1 value, which is an indicator commonly used to measure the performance of the two-class model.
High-Throughput Sequencing to Identify Mutations Associated with Retinal Dystrophies
Authors: Song Fei , Owczarek-Lipska Marta , Ahmels Tim , Book Marius , Aisenbrey Sabine , Menghini Moreno , Barthelmes Daniel , Schrader Stefan , Spital Georg , Neidhardt John
Published: August 2021

Retinal dystrophies (RD) are clinically and genetically heterogenous disorders showing mutations in over 270 disease-associated genes. Several millions of people worldwide are affected with different types of RD. Studying the relevance of disease-associated sequence alterations will assist in understanding disorders and may lead to the development of therapeutic approaches. Here, we established a whole exome sequencing (WES) pipeline to rapidly identify disease-associated mutations in patients. Sanger sequencing was applied to identify deep-intronic variants and to verify the co-segregation of WES results within families. We analyzed 26 unrelated patients with different syndromic and non-syndromic clinical manifestations of RD. All patients underwent ophthalmic examinations. We identified nine novel disease-associated sequence variants among 37 variants identified in total. The sequence variants located to 17 different genes. Interestingly, two cases presenting with Stargardt disease carried deep-intronic variants in ABCA4. We have classified 21 variants as pathogenic variants, 4 as benign/likely benign variants, and 12 as variants of uncertain significance. This study highlights the importance of WES-based mutation analyses in RD patients supporting clinical decisions, broadly based genetic diagnosis and support genetic counselling. It is essential for any genetic therapy to expand the mutation spectrum, understand the genes’ function, and correlate phenotypes with genotypes.
Uniparental Lineages from the Oldest Indigenous Population of Ecuador: The Tsachilas
Authors: Di Corcia Tullia , Scano Giuseppina , Martínez-Labarga Cristina , Sarno Stefania , De Fanti Sara , Luiselli Donata , Rickards Olga
Published: August 2021

Together with Cayapas, the Tsachilas constitute the oldest population in the country of Ecuador and, according to some historians, they are the last descendants of the ancient Yumbos. Several anthropological issues underlie the interest towards this peculiar population: the uncertainty of their origin, their belonging to the Barbacoan linguistic family, which is still at the center of an intense linguistic debate, and the relations of their Yumbo ancestors with the Inca invaders who occupied their ancient territory. Our contribution to the knowledge of their complex past was the reconstruction of their genetic maternal and paternal inheritance through the sequencing of 70 entire mitochondrial genomes and the characterization of the non-recombinant region of the Y chromosome in 26 males. For both markers, we built comprehensive datasets of various populations from the surrounding geographical area, northwestern South America, NW, with a known linguistic affiliation, and we could then compare our sample against the overall variability to infer relationships with other Barbacoan people and with other NW natives. We found contrasting patterns of genetic diversity for the two markers, but generally, our results indicated a possible common origin between the Tsachilas, the Chachi, and other Ecuadorian and Colombian Barbacoans and are suggestive of an interesting ancient linkage to the Inca invaders in Yumbo country.
COVID-19 Stressors on Migrant Workers in Vietnam: Cumulative Risk Consideration
Authors: Bui Ha Thi Thu , Duong Duc Minh , Pham Thanh Quoc , Mirzoev Tolib , Bui Anh Thi My , La Quang Ngoc
Published: August 2021

This study explored the impact of COVID-19 on migrant workers in Vietnam, using a cumulative risk assessment (CRA) framework which comprises four domains (workplace, environment, individual and community). A cross-sectional study was conducted. Data were collected in 2020 through a self-administered questionnaire with 445 domestic migrant workers in two industrial zones in two northern provinces (Bac Ninh and Ninh Binh) in Vietnam. The majority of migrant workers were female (65.2%), aged between 18 and 29 years old (66.8%), and had high school or higher education level qualifications. Most migrant workers had good knowledge about preventive measures (>90%) and correct practices on COVID-19 prevention (81.1%). Three health risk behaviors were reported: 10% of participants smoked, 25% consumed alcohol and 23.1% were engaged in online gaming. In terms of workplace, occupational working conditions were good. Noise was the most commonly reported hazard (29%). Regarding environment, about two-thirds of migrant workers lived in a small house (<36 m2). Most participants (80.4%) lived with their families. About community domain, many reported low salary or losing their job during January–July, 2020. Most migrants received information about COVID-19. The migrant workers suffered from poor health and low occupational safety, fear of job loss and income cut, poor housing and living conditions and limited access to public services. The holistic approach to address stressors is recommended to improve health and safety of migrant workers.
What Happens When People with Depression Gather Online?
Authors: Wang Xuening , Tian Xianyun , Pan Xuwei , Wei Dongxu , Qi Qi
Published: August 2021

Depression is a common mental disease that impacts people of all ages and backgrounds. To meet needs that cannot otherwise be met, people with depression or who tend to suffer from depression often gather in online depression communities. However, since joining a depression community exposes members to the depression of others, the impact of such communities is not entirely clear. This study therefore explored what happens when people with depression gather in Sina Weibo’s Depression Super Topic online community. Through website crawling, postings from Depression Super Topic were compared with postings from members’ regular timelines with respect to themes, emotions disclosed, activity patterns, and the number of likes and comments. Topics of distilled postings covering support, regulations, emotions and life sharing, and initiating discussions were then coded. From comparison analysis, it was found that postings in the Depression Super Topic community received more comments and disclosed more emotions than regular timelines and that members were more active in the community at night. This study offers a picture of what occurs when people with depression gather online, which helps better understand their issues and therefore provide more targeted support.
Autosomal Dominant Hypophosphatemic Rickets: A Case Report and Review of the Literature
Authors: Mameli Chiara , Sangiorgio Arianna , Colombo Valeria , Gambino Mirko , Spaccini Luigina , Cattaneo Elisa , Zuccotti Gian Vincenzo
Published: August 2021

Autosomal dominant hypophosphatemic rickets (ADHR) is an extremely rare form of genetic rickets caused by mutations in the fibroblast growth factor 23 gene. ADHR is characterized by hypophosphatemia secondary to isolated renal phosphate wasting. Only a few cases of ADHR have been reported in the literature to date. We describe the case of a 17-month-old girl who presented with severe failure to thrive (length: −4.08 standard deviation (SD), weight: −2.2 SD) and hypotonia. Hypophosphatemia, decreased tubular phosphate reabsorption (69%), and rachitic lesions were found. Genetic analysis showed the heterozygous variant c.536G>A (NM_020638.3:c.536G>A) in exon 3 of the FGF23 gene, leading to the diagnosis of ADHR. She was treated with phosphate salts and oral alfacalcidol. After 4 years of treatment, at 5 years of age, the patient’s ADHR resolved spontaneously. Considering the lack of knowledge regarding ADHR, we reviewed the literature to describe the features of this rare and poorly understood disease. Eleven ADHR pediatric cases have been described thus far, with cases tending to be more common in females than males. Similar to the general population, two groups of patients with ADHR can be described depending on the mutations present: patients with an R179 and R176 mutation have early-onset of disease and higher frequency of rickets, and a milder and late-onset of disease, respectively. Symptoms and disease severity may fluctuate. Spontaneous remission may occur during the pediatric age.
Flaminio Rota: Fame and Glory of a 16th Century Anatomist without Scientific Publications
Authors: Natale Gianfranco , Soldani Paola , Gesi Marco , Armocida Emanuele
Published: August 2021

Academic activity is intrinsically composed of two aspects: teaching and research. Since the 20th century, the aphorism “publish or perish” has overwhelmingly established itself in the academic field. Research activity has absorbed more attention from the professors who have neglected teaching activity. In anatomical sciences, research has focused mainly on ultrastructural anatomy and biochemical aspects, far removed from the topics addressed to medical students. Will today’s anatomists be rewarded by their choice? To generate a forecast, we should entrust what history has already taught us. For this analysis, an example was taken, concerning the fate that history reserved for the anatomy teachers of the University of Bologna in the second half of the 16th century. Thanks to Vesalius (1514–1564), experimentation on the human body replaced the old dogmatic knowledge, and didactic innovation was one with research. Some figures were highly praised despite their poor scientific production. The present article focuses on the figure of Flaminio Rota, who was highly esteemed by his colleagues in spite of no significant scientific activity. Reasons for this paradox are examined. Then, history also whispers to us: publish, but without perishing in the oblivion of students.
Changes in Depressive Symptoms, Stress and Social Support in Mexican Women during the COVID-19 Pandemic
Authors: Rivera Rivera Nadya Y. , McGuinn Laura , Osorio-Valencia Erika , Martinez-Medina Sandra , Schnaas Lourdes , Wright Rosalind J. , Téllez-Rojo Martha Maria , Wright Robert O. , Tamayo-Ortiz Marcela , Rosa Maria José
Published: August 2021

The aim of this study was to examine changes in depression, stress and social support levels before and during the COVID-19 pandemic in women living in Mexico City. We studied 466 women enrolled in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study who completed the Edinburgh Depression Scale (EDS) questionnaire prior (2018–2019) and during the lockdown period of the pandemic (May–November 2020). Psychosocial stress and social support for both time periods were ascertained using the Crisis in Family Systems (CRISYS) questionnaire and the Social Support Network (SSN) Scale, respectively. Associations between stress, social support and change in EDS score/depression were analyzed using generalized linear models adjusting for covariates. Higher stress (>median) during the pandemic was associated with an increase in EDS score (β: 2.13; 95% CI (1.06, 3.19), p < 0.001), and higher odds of depression (OR: 3.75; 95% CI (2.17, 6.50), p < 0.001), while social support was associated with lower odds of depression (OR: 0.56, 95% CI (0.32, 0.97), p = 0.037). Higher levels of stress during the pandemic were associated with depression. Social support may act as a buffer for the effects of psychosocial stress. Future studies should examine the long-term effects of stress associated with the pandemic on mental and overall health.
Comparison of Postoperative Pain and Adverse Effects between Variable-Rate Feedback Infusion and Conventional Fixed-Rate Basal Infusion Modes of Patient-Controlled Epidural Analgesia following Open Gastrectomy: A Randomized Controlled Trial
Authors: Jang Yoo Kyung , Kim Na Young , Lee Jeong Soo , Shin Hye Jung , Kim Hyoung Gyun , Lee Suk Woo , Koh Jae Chul , Yoo Young Chul
Published: August 2021

Patient-controlled epidural analgesia is widely used to control postoperative pain following major intra-abdominal surgeries. However, determining the optimal infusion dose that can produce effective analgesia while reducing side effects remains a task to be solved. Postoperative pain and adverse effects between variable-rate feedback infusion (VFIM group, n = 36) and conventional fixed-rate basal infusion (CFIM group, n = 36) of fentanyl/ropivacaine-based patient-controlled epidural analgesia were evaluated. In the CFIM group, the basal infusion rate was fixed (5 mL/h), whereas, in the VFIM group, the basal infusion rate was increased by 0.5 mL/h each time a bolus dose was administered and decreased by 0.3 mL/h when a bolus dose was not administered for 2 h. Patients in the VFIM group experienced significantly less pain at one to six hours after surgery than those in the CFIM group. Further, the number of patients who suffered from postoperative nausea was significantly lower in the VFIM group than in the CFIM group until six hours after surgery. The variable-rate feedback infusion mode of patient-controlled epidural analgesia may provide better analgesia accompanied with significantly less nausea in the early postoperative period than the conventional fixed-rate basal infusion mode following open gastrectomy.
Perception of the Movement Control Order during the COVID-19 Pandemic: A Qualitative Study in Malaysia
Authors: Tay Yea Lu , Abdullah Zalilah , Chelladorai Kalvina , Low Lee Lan , Tong Seng Fah
Published: August 2021

Malaysia implemented its first Movement Control Order (MCO) during the early phase of the COVID-19 pandemic to slow the transmission of the virus. This study aimed to explore the public perception of the MCO implementation and people’s experiences during this period. The study employed qualitative explorative in-depth interviews conducted with 23 Malaysian adults from various demographic backgrounds. Thematic analysis was performed using NVivo 12. Three main themes were identified: a period of information surge, heterogeneous emotional response, and attempts to adapt. During the MCO, the participants obtained information from multiple platforms. They suggested the need for clear and repeated instructions to avoid confusion and misinformation. They also acknowledged the importance of the MCO in breaking the chain of transmission and safeguarding high-risk groups; however, they also expressed that stricter enforcement from the authorities was warranted. The changes in the participants’ work–life routines, lack of physical interaction, and uncertainty about their health and the economy due to the MCO negatively impacted their psychological states. Despite these challenges, the participants attempted to adapt to life under the MCO in different ways. The findings imply that during a crisis, the public tends to seek clear and reliable information, experience emotional turmoil, and adapt to changes. The MCO implementation can be improved through an effective communication strategy and efforts to battle misinformation.
Physical Functioning, Depressive Symptoms, and Suicidal Ideation among Older Korean Adults
Authors: Sim Hyung-Seop , Lee Sang-Gyu , Kim Tae-Hyun
Published: August 2021

Previous studies have shown that the physical functioning of older adults directly affects their depressive symptoms, and suicide is also closely associated with depression. This study determined the effects of physical functioning on depressive symptoms and suicidal ideation among older Korean adults. This study used data from the 2017 National Survey of Older Persons. Among the 10,299 participants in the entire data set, 10,083 participants were analyzed, excluding 216 participants who did not respond to the dependent variables. Data analyses included frequency, chi-squared tests, and binary logistic regression. The results indicated that physical functioning among older adults was associated with reduced depressive symptoms and suicidal ideation. Compared to the group that had non-limited activities of daily living (ADL) function, the group with limitations was 1.66 times more likely to show depressive symptoms (OR: 1.66, 95% CI: 1.36–2.02). Similar trends were observed in instrumental activities of daily living (IADL) (OR: 1.85, 95% CI: 1.58–2.16). When suicidal ideation was set as a dependent variable, IADL had a statistically significant impact (OR: 1.41, 95% CI: 1.14–1.74); however, ADL did not seem to have an impact. Moreover, both ADL (OR: 1.62, 95% CI: 1.35–1.94) and IADL (OR: 1.72, 95% CI: 1.49–1.97) had statistically significant effects when combined with depressive symptoms and suicidal ideation. Better physical functioning was associated with a reduction in depressive symptoms and suicidal ideation. This study emphasizes the importance of physical functioning when examining older adults’ mental health.
The Impact of Suicide Utility Perception on News over Terminally Ill Patients’ Suicide Attitudes: A Pilot Study
Authors: Garcia-Fernández Diego , Fernández-Salinero Samuel , Giorgi Gabriele , Topa Gabriela , Marcos Del Cano Ana María
Published: August 2021

Suicide represents a very important issue in public health. For approaching attitudes toward suicide, we have developed an instrument that, following previous recommendations, assesses specific thoughts related to the perception of suicide utility in the press. First of all, we will test the psychometric properties of the scale we created ad hoc for assessing suicide utility perception. After that, we expect to find that the suicide utility perception in the press will have a statistically significant impact on positive attitudes toward terminally ill patients’ suicide (Hypothesis 1). In addition, this relationship will be mediated by suicide legitimation (Hypothesis 2). This mediation will be moderated by depressive symptomatology (Hypothesis 3). The sample was composed of 66 Spanish participants. Suicide legitimation was significantly related to the positive evaluation of terminally ill people’s euthanasia. Finally, when the levels of depression’s psychological concomitants increased, the support for terminally ill people’s euthanasia increased as well. Implications and limitations have been discussed.
Social Support and Dietary Habits as Anxiety Level Predictors of Students during the COVID-19 Pandemic
Authors: Ortenburger Dorota , Mosler Dariusz , Pavlova Iuliia , Wąsik Jacek
Published: August 2021

The COVID-19 pandemic is a public health emergency concern and a challenge to students’ mental health due to changes in education and social isolation. The aim of this research was to expand knowledge about the relations that shape the level of anxiety amongst men and women who are studying during the pandemic in terms of the relations towards their sense of social support and their nutritional behaviors. A State–Trait Anxiety Inventory was used to measure anxiety level, alongside supplementary questions such as the feeling of support from close ones, concentration of attention on nutrition during the pandemic and externally derived factors (university, specialization). Analysis of the regression was applied to the examination of the dependency between the anxiety level (in both forms of its occurrence—as state-anxiety and as trait-anxiety). We observed that the pandemic situation affected a level of state-anxiety above average (mean value of 46–48 points) even when students felt social support. Nutrition habits and chosen education type are associated with trait-anxiety level, which was also elevated (mean values of 49–50 points). Chosen factors had a partial influence on the anxiety level of students, therefore their mental health should concern shaping positive nutrition habits and social support.
Development of Framework for Estimating Fatality-Related Losses in the Korean Construction Industry
Authors: Lee Jaehyun , Jeong Jaewook , Soh Jayho , Jeong Jaemin
Published: August 2021

The number of fatalities in the construction industry is highest among all industries; thus, various losses in the form of fatalities in construction represent a significant factor for safety management. If a fatality occurs, it is important to estimate the overall loss, as a significant financial loss occurs for each project participant. However, in studies of the cost of accidents involving a fatality conducted abroad, the framework cannot be applied as it is because insurance types, systems, and legal cost systems differ by country. Therefore, we developed a framework for calculating the fatality loss considering various aspects of labor, industry, and regulations in Korea. This was done in four steps: (i) data collection and criteria selection; (ii) proposed framework development; (iii) conduct of questionnaire surveys for the case study; and (iv) analysis and evaluation of the case study. As a result of the data analysis after the case study of general construction companies, the total fatality loss was estimated to be 2,198,260 USD/person. The contributions of this study are the development of a framework composed of newly discovered items that can acquire reliable data in consideration of the properties of the construction industry.
Social Determinants on Suicidal Thoughts among Young Adults
Authors: Wang Gang , Wu Liyun
Published: August 2021

Objective. The main objective of this study was to investigate the relationship between poverty, religion, and suicidal thoughts among U.S. youth. The disparities regarding gender, race, and ethnicity with regard to suicidal thoughts were also assessed. Methods. A cross-sectional correlational research design was used for this study and a national representative sample of 1945 young adults aged 18 to 25 was selected from the 2014 National Survey on Drug Use and Health. Logistic regression analysis with interaction effects was utilized to determine if poverty and religion were associated with suicidal thoughts. Results. About 43 percent of the sample reported having suicidal thoughts when things got worse and this prevalence rate varied by gender and race/ethnicity with white males self-disclosing the highest rate of suicidal thoughts. After adjusting for demographic and socioeconomic characteristics, black males who lived up to two times the poverty line had a higher likelihood of suicidal thoughts (p = 0.011), and religion protected against suicidal thoughts (p = 0.012). Youth with lower education and poor health were more inclined to have suicidal thoughts than their peers. Conclusions. Suicide is the second leading cause of death for American young adults aged 18 to 25. Understanding these differences between social determinants of suicide can help public health researchers strategize how to make evidence-based recommendations for suicide prevention efforts.
Long-Term Impact of COVID-19 on Mental Health among the General Public: A Nationwide Longitudinal Study in China
Authors: Shi Le , Lu Zheng-An , Que Jian-Yu , Huang Xiao-Lin , Lu Qing-Dong , Liu Lin , Zheng Yong-Bo , Liu Wei-Jian , Ran Mao-Sheng , Yuan Kai , Yan Wei , Sun Yan-Kun , Sun Si-Wei , Shi Jie , Kosten Thomas , Bao Yan-Ping , Lu Lin
Published: August 2021

COVID-19 might have long-term mental health impacts. We aim to investigate the longitudinal changes in mental problems from initial COVID-19 peak to its aftermath among general public in China. Depression, anxiety and insomnia were assessed among a large-sample nationwide cohort of 10,492 adults during the initial COVID-19 peak (28 February 2020 to 11 March 2020) and its aftermath (8 July 2020 to 8 August 2020) using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Insomnia Severity Index. We used generalized estimating equations and linear mixed models to explore factors associated with long-term mental health symptoms during COVID-19. During the five months, mental health symptoms remained consistently elevated (baseline 46.4%; follow-up 45.1%). Long-term depression, anxiety and insomnia were associated with several personal and work-related factors including quarantine (adjusted OR for any mental health symptoms 1.31, 95%CI 1.22–1.41, p < 0.001), increases in work burden after resuming work (1.77, 1.65–1.90, p < 0.001), occupational exposure risk to COVID-19 (1.26, 1.14–1.40, p < 0.001) and living in places severely affected by initial COVID-19 peak (1.21, 1.04–1.41, p = 0.01) or by a COVID-19 resurgence (1.38, 1.26–1.50, p < 0.001). Compliance with self-protection measures, such as wearing face masks (0.74, 0.61–0.90, p = 0.003), was associated with lower long-term risk of mental problems. The findings reveal a pronounced and prolonged mental health burden from the initial COVID-19 peak through to its aftermath in China. We should regularly monitor the mental health status of vulnerable populations throughout COVID-19.
Perception of Harmfulness of Various Tobacco Products and E-Cigarettes in Poland: A Nationwide Cross-Sectional Survey
Authors: Jankowski Mateusz , Wrześniewska-Wal Iwona , Ostrowska Aurelia , Lusawa Aleksandra , Wierzba Waldemar , Pinkas Jarosław
Published: August 2021

Perceptions of the harmfulness of tobacco products may be a determinant of smoking behaviors. This study aimed to: (1) assess the perception of harmfulness of various tobacco products and e-cigarettes in Poland as well as (2) to assess the awareness of the health effects of using tobacco and e-cigarettes. A cross-sectional survey was conducted in 2019 with a nationally representative sample of 1011 individuals aged 15 and over. In the studied group, 22.3% were smokers. Smokeless tobacco was most likely to be perceived as less harmful than cigarettes (25%), followed by water pipe (24.5%), heated tobacco products (22%), e-cigarettes (21.6%), slim cigarettes (17.1%), flavored cigarettes (except menthol ones) (16.1%), menthol cigarettes (15.6%) and cigarillos (12.6%). In this study, 10% of respondents denied that smoking causes serious diseases. Most of the respondents (88.9%) were aware that smoking causes lung cancer (88.9%), but only 70.4% were aware that smoking causes stroke. Smokers compared to non-smokers were less likely to declare that smoking causes a stroke (OR: 0.43, 95%CI: 0.31–0.59; p < 0.001) or myocardial infarction (OR: 0.41, 95%CI: 0.29–0.60; p < 0.001). There were no significant differences (p > 0.05) in the perception of harmfulness of various tobacco products and e-cigarettes by gender, age, or occupational status.
Design of a Microbial Remediation Inoculation Program for Petroleum Hydrocarbon Contaminated Sites Based on Degradation Pathways
Authors: Li Xingchun , He Wei , Du Meijin , Zheng Jin , Du Xianyuan , Li Yu
Published: August 2021

This paper analyzed the degradation pathways of petroleum hydrocarbon degradation bacteria, screened the main degradation pathways, and found the petroleum hydrocarbon degradation enzymes corresponding to each step of the degradation pathway. Through the Copeland method, the best inoculation program of petroleum hydrocarbon degradation bacteria in a polluted site was selected as follows: single oxygenation path was dominated by Streptomyces avermitilis, hydroxylation path was dominated by Methylosinus trichosporium OB3b, secondary oxygenation path was dominated by Pseudomonas aeruginosa, secondary hydroxylation path was dominated by Methylococcus capsulatus, double oxygenation path was dominated by Acinetobacter baylyi ADP1, hydrolysis path was dominated by Rhodococcus erythropolis, and CoA path was dominated by Geobacter metallireducens GS-15 to repair petroleum hydrocarbon contaminated sites. The Copeland method score for this solution is 22, which is the highest among the 375 solutions designed in this paper, indicating that it has the best degradation effect. Meanwhile, we verified its effect by the Cdocker method, and the Cdocker energy of this solution is −285.811 kcal/mol, which has the highest absolute value. Among the inoculation programs of the top 13 petroleum hydrocarbon degradation bacteria, the effect of the best inoculation program of petroleum hydrocarbon degradation bacteria was 18% higher than that of the 13th group, verifying that this solution has the best overall degradation effect. The inoculation program of petroleum hydrocarbon degradation bacteria designed in this paper considered the main pathways of petroleum hydrocarbon pollutant degradation, especially highlighting the degradability of petroleum hydrocarbon intermediate degradation products, and enriching the theoretical program of microbial remediation of petroleum hydrocarbon contaminated sites.
Thirty-Day Readmission Rates after Takotsubo Syndrome with or without Malignancy: A Nationwide Readmissions Database Analysis
Authors: Jang Sun-Joo , Yeo Ilhwan , Jonas Chanel , Goyal Parag , Cheung Jim W. , Feldman Dmitriy N. , McCullough S. Andrew , Krishnan Udhay , Narotsky David L. , Singh Harsimran S. , Minutello Robert M. , Bergman Geoffrey , Wong S. Chiu , Kim Luke K.
Published: August 2021

The association between malignancy and readmission after Takotsubo syndrome (TTS) hospitalization has not been fully described. We sought to examine the rates, cause, and cost of 30-day readmissions of TTS, with or without malignancy, by utilizing Nationwide Readmissions Databases from 2010 to 2014. We identified 61,588 index hospitalizations for TTS. TTS patients with malignancy tended to be older (70.6 ± 0.2 vs. 66.1 ± 0.1, p < 0.001), and the overall burden of comorbidities was higher than in those without malignancy. TTS patients with malignancy had significantly higher 30-day readmission rates than those without malignancy (15.9% vs. 11.0%; odds ratio (OR), 1.35; 95% confidence interval (CI), 1.18–1.56). Non-cardiac causes were the most common causes of readmission for TTS patients with malignancy versus without malignancy (75.5% vs. 68.1%, p < 0.001). The 30-day readmission rate due to recurrent TTS was very low in both groups (0.4% and 0.5%; p = 0.47). The total costs were higher by 25% (p < 0.001) in TTS patients with vs. without malignancy. In summary, among patients hospitalized with TTS, the presence of malignancy was associated with increased risk of 30-day readmission and increased costs. These findings highlight the importance of optimized management for TTS patients with malignancy.
Perceptions about Research Participation among Individuals at Risk and Individuals with Premanifest Huntington’s Disease: A Survey Conducted by the European Huntington Association
Authors: Júlio Filipa , Blanco Ruth , Casanova Josè Perez , D’Alessio Barbara , De Schepper Beatrice , De Sousa Dina , De Sousa Paul , Ferreira Cristina , Gommans Hans , Haselberg Rob , Hermant Emilie , Lis Danuta , Maffi Sabrina , Olsen Svein Olaf , Papantoniou Marios , Squitieri Ferdinando , Tretyakova Marina , Umakhanova Zaynab , Václavík Vladimír , Winkelmann Michaela , Arnesen Astri ,   on behalf of the European Huntington Association
Published: August 2021

There has been great progress in Huntington’s disease (HD) research. Yet, effective treatments to halt disease before the onset of disabling symptoms are still unavailable. Scientific breakthroughs require an active and lasting commitment from families. However, they are traditionally less involved and heard in studies. Accordingly, the European Huntington Association (EHA) surveyed individuals at risk (HDRisk) and with premanifest HD (PreHD) to determine which factors affect their willingness to participate in research. Questions assessed research experience and knowledge, information sources, reasons for involvement and noninvolvement, and factors preventing and facilitating participation. The survey included 525 individuals, of which 68.8% never participated in studies and 38.6% reported limited research knowledge. Furthermore, 52% trusted patient organizations to get research information. Reasons for involvement were altruistic and more important than reasons for noninvolvement, which were related to negative emotions. Obstacles included time/financial constraints and invasive procedures, while professional support was seen as a facilitator. PreHD individuals reported less obstacles to research participation than HDRisk individuals. Overall, a high motivation to participate in research was noted, despite limited experience and literacy. This motivation is influenced by subjective and objective factors and, importantly, by HD status. Patient organizations have a key role in fostering motivation through education and support.
Sphingosine-1-Phosphate Induces ATP Release via Volume-Regulated Anion Channels in Breast Cell Lines
Authors: Furuya Kishio , Hirata Hiroaki , Kobayashi Takeshi , Sokabe Masahiro
Published: August 2021

High interstitial level of ATP and its lysate adenosine in the cancer microenvironment are considered a halo mark of cancer. Adenosine acts as a strong immune suppressor. However, the source of ATP release is unclear. We clarified the release of ATP via volume-regulated anion channels (VRACs) in breast cell lines using an ATP luminescence imaging system. We detected a slowly rising diffuse pattern of ATP release that was only observed in undifferentiated cells, not in differentiated primary cultured cells. This was confirmed by suppression with DCPIB, a blocker of VRACs, and shRNA for LRRC8A, an indispensable subunit of VRACs. We herein demonstrated that the inflammatory mediator sphingosine-1-phosphate (S1P), which exists abundantly in the cancer microenvironment, induced a diffuse pattern of ATP release isovolumetrically. The response was dose-dependent and suppressed by the knock-down of LRRC8A. It was also suppressed by blockers of S1P receptor 1 and 2 (W146 and JTE013, respectively). RTqPCR demonstrated the prominent presence of S1PR1 and S1PR2 mRNAs. We discussed the roles of S1P-induced ATP release in the cancer microenvironment.
Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis
Authors: Peregrina Alexandra , Martins-Lourenço João , Freitas Filomena , Reis Maria A. M. , Arraiano Cecília M.
Published: August 2021

The large production of non-degradable petrol-based plastics has become a major global issue due to its environmental pollution. Biopolymers produced by microorganisms such as polyhydroxyalkanoates (PHAs) are gaining potential as a sustainable alternative, but the high cost associated with their industrial production has been a limiting factor. Post-transcriptional regulation is a key step to control gene expression in changing environments and has been reported to play a major role in numerous cellular processes. However, limited reports are available concerning the regulation of PHA accumulation in bacteria, and many essential regulatory factors still need to be identified. Here, we review studies where the synthesis of PHA has been reported to be regulated at the post-transcriptional level, and we analyze the RNA-mediated networks involved. Finally, we discuss the forthcoming research on riboregulation, synthetic, and metabolic engineering which could lead to improved strategies for PHAs synthesis in industrial production, thereby reducing the costs currently associated with this procedure.
Structure and Strength of Artificial Soils Containing Monomineral Clay Fractions
Authors: Jozefaciuk Grzegorz , Skic Kamil , Adamczuk Agnieszka , Boguta Patrycja , Lamorski Krzysztof
Published: August 2021

Structure and strength are responsible for soil physical properties. This paper determines in a uniaxial compression test the strength of artificial soils containing different proportions of various clay-size minerals (cementing agents) and silt-size feldspar/quartz (skeletal particles). A novel empirical model relating the maximum stress and the Young’s modulus to the mineral content basing on the Langmuir-type curve was proposed. By using mercury intrusion porosimetry (MIP), bulk density (BD), and scanning electron microscopy (SEM), structural parameters influencing the strength of the soils were estimated and related to mechanical parameters. Size and shape of particles are considered as primary factors responsible for soil strength. In our experiments, the soil strength depended primarily on the location of fine particles in respect to silt grains and then, on a mineral particle size. The surface fractal dimension of mineral particles played a role of a shape parameter governing soil strength. Soils containing minerals of higher surface fractal dimensions (rougher surfaces) were more mechanically resistant. The two latter findings appear to be recognized herein for the first time.