bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunohistochemical evaluation of P53 in squamous cell carcinoma of the esophagus
Authors: K Kala , G Sarumathy , I Nithya , A Prathiba
Published: January 2025

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of cancer, particularly prevalent in regions such as East Asia and parts of Africa. The etiology of ESCC is complex, involving a combination of genetic, environmental, and lifestyle factors. Among the molecular alterations associated with ESCC, mutations and dysregulation of the p53 tumor suppressor gene have garnered significant attention. The aim was to study the expression of p53 in histologically proven squamous cell carcinoma of esophagus and to correlate p53 positivity with the grade of the tumor along with other clinicopathological parameters.

Materials and methods: This is a retrospective study of squamous cell carcinoma of the oesophagus and in this study, for 55 cases of ESCC p53 gene expression was analyzed by Immunohistochemistry and these findings were then compared with clinicopathological parameters.

Results: In this study 35(63.6%) were males and 20(36.4%) were females. The expression of p53 in ESCC patients significantly correlates with age and betel nut chewing. Only 38% of well differentiated tumors showed positive p53 expression when compared to moderately differentiated and poorly differentiated tumors, which showed 71% and 85% positivity respectively. So there was significant correlation between P53 expression and histological grade of tumor. There were no significant associations between p53 expression and site, lymph node metastasis (N classification) and stage.

Conclusion: In conclusion, the expression of p53 in ESCC patients significantly correlates with age, betel nut chewing and histological grade. p53 play an important role in tumor progression and an independent variable affecting the survival.
A study of serum prolactin in dermatological diseases in a tertiary care hospital of Assam
Authors: C Talukdar , B Boro
Published: January 2025

Background: Prolactin functions as a neuroendocrine modulator of the skin immune system and epithelial cell proliferation. Prolactin and the immune system inter relationship have been studied extensively and opened new avenues in the field of immunoendocrinology. Prolactin may have an important role in some dermatological diseases like psoriasis, alopecia areata, and vitiligo. We aim to estimate serum prolactin values in patients of psoriasis, alopecia areata and vitiligo and compare it with healthy controls and also evaluate the correlation between serum prolactin levels and severity of the diseases.

Methods: We performed a case–control study on 200 subjects which include 150 patients; suffering from psoriasis, alopecia areata and vitiligo; 50 patients in each group and 50 age- and sex-matched healthy controls. The serum prolactin level was measured in patients and control groups using enzyme linked immunosorbent assay (ELISA).

Results: Serum prolactin levels were significantly high in all three dermatological diseases in comparison with the control group (P <0.05). The mean ± SD of the serum prolactin levels was 19.2 ± 6.7 ng/ml, 20.6± 6.9 ng/ml, and 16.4 ± 6.2 ng/ml in patients with psoriasis, alopecia areata, and vitiligo respectively. Moreover the serum prolactin levels in patients with psoriasis and alopecia areata were significantly correlated with disease severity (P <0.05).

Conclusions: Prolactin may play a role in the pathogenesis of psoriasis, alopecia areata, and vitiligo; and may serve as a biochemical marker of disease severity in patients with psoriasis and alopecia areata.
Gall bladder wall thickness and C-reactive protein as a predictor of difficult laparoscopic cholecystectomy
Authors: A Nair , A Appukuttan , J Mathew , AN Oommen , A Joseph
Published: January 2025

Over the past two decades, laparoscopic cholecystectomy has become the preferred method for treating gallstone disease. Despite its many benefits, it is not without potential complications. Accurately predicting the complexity of the surgery remains a challenge. Currently, the duration of a patient’s symptoms is the main criterion for assessing surgical risk. In this study, we hypothesized that increased gallbladder wall thickness and elevated preoperative C-reactive protein (CRP) levels, which are objective markers of inflammation or fibrosis, would be linked to increased difficulty in laparoscopic cholecystectomy. The study spanned 18 months and included 50 patients who met specific inclusion criteria, all of whom underwent either early or interval laparoscopic cholecystectomy. Preoperative ultrasound and CRP values were evaluated, and surgical difficulty was measured using a scoring system. ROC curve analysis was employed to assess CRP as a predictor of difficult laparoscopic cholecystectomy. Intraoperative difficulty was assessed using the Nassar scale. Of the 50 patients, 22 (44%) had grade 1 difficulty, 18 (36%) had grade 2 difficulty, 8 (16%) had grade 3 difficulty, and 2 (4%) had grade 4 difficulty. The chi-square test for the association between gallbladder wall thickness and the difficulty of laparoscopic cholecystectomy revealed a highly significant p-value of <0.001, with a Pearson chi-square statistic of 12.5. ROC analysis indicated that CRP is a reliable predictor of surgical difficulty, with an AUC of 0.790 (95% CI, 0.606-0.974). These findings emphasize the importance of preoperative evaluation of GBWT and CRP, as they can help anticipate surgical challenges, improve planning, and enhance patient outcomes.
Outcome of dual implantation in distal end femur fractures among patients attending a tertiary care hospital in Karnataka
Authors: SVA Kumar , SH Vishnuprasad , V Vittal , P Diwakar , SAK Zai
Published: January 2025

Background: Distal femur fractures, comprising 6% of femur fractures. These fractures demand precise surgical interventions, especially Muller’s Type C2 and C3 variants, necessitating stable fixation. Dual implants like double-plate and plate-and-nail constructs offer promising anatomical reconstruction. The study was done to estimate the effect of dual implantation in distal femur fracture on union and clinical outcomes of the patients.

Methods: Study was done on 30 patients who underwent dual implantation surgery for distal femur fractures. We specifically focused on Muller's C2 and C3 types, and included cases of periprosthetic fracture or implant failure. Patient demographics, medical histories, fracture characteristics (laterality, type, knee status, injury mode, and associated injuries), and clinical outcomes after follow-up were extracted from records and through clinical observation. Analysis done through R-Software.

Results: Study participants primarily aged above 60 years (30.0%), mostly males (53.3%), exhibited fractures over the right femur (63.3%). Muller’s Type C3 fractures were predominant (66.7%), often associated with comorbidities (60.0%) and risk factors (43.3%), mainly RTAs (53.35%). Plate-plate constructs were common (73.3%), with favorable outcomes in 83.3% showing complete healing and 66.7% normal working capacity. Complications occurred in 60.0%, mainly limb length discrepancy (43.3%), valgus deformity (36.7%), and infection (16.7%). There is no statistically significant difference in outcome between type of fractures and dual implants used.

Conclusion: For distal femur fractures, particularly Muller's type-C2 and C3, Dual implants, such as dual plates or plate with nail, offer favorable clinical outcomes, acceptable knee motion, high union rates, and optimal supra patella area reconstruction, and thus can be recommended as a standard procedure for managing complex distal femur injuries.
Evaluation of home based insulin therapy among pediatric patients with type I diabetes mellitus - A prospective analytical study
Authors: N Soundararajan , A Thangavel , D Vidjeadevan , A Vijayaraghavan
Published: January 2025

Background: Home based insulin therapy is one of the major challenges faced by the Type I diabetes mellitus (T1DM) patients with regards to the injection technique and correct dosing. The study aimed to assess the home based insulin therapy and its complications and to evaluate the impact of counselling on home based insulin therapy among Type I diabetes mellitus patients.

Methodology: A prospective analytical study was conducted at Institution of Child Health, Egmore for a period of one year. Children of age less than 15 years and are newly diagnosed with type I diabetes or recently diagnosed diabetes of less than 18 months duration were included as our study subjects. A non-random quota sampling technique was followed for sample calculation and based on that 85 children satisfying our inclusion and exclusion criteria were selected as our study sample.

Results: The demographic details shows that the mean age among males was 10.2 ± 3.2 and for females it was 8.9 ± 2.8 and the male: female ratio was 0.88: 1. It was observed among the study subjects that there was a regular improvement in their knowledge and practice over a period of time, during each visit the number of care givers with correct knowledge and practice were increasing starting from base level assessment to third follow-up visit and it was found to be statistically significant (p<.001).

Conclusion: The present study has proven that repeated education and proper training given to the care providers of Type I DM patients plays a major role in control of their diabetic status as well as preventing them from developing injection site complications.
Correlation of blood coagulation parameters with comorbidities in COVID-19 patients: A retrospective study
Authors: N Shuba , A Michael
Published: January 2025

COVID-19 is a respiratory pathogenic strain with the potential to cause severe systemic inflammation and coagulopathy. Moreover, dysfunctional coagulation cascades in diabetes mellitus and an imbalance of cytokines in hypertension and cardiovascular diseases may pose an additional risk towards hypercoagulability and subsequent mortality amid those with COVID-19. In this study, blood parameters that influence coagulation such as platelets, d-dimer and NLR ratios (neutrophil / lymphocyte ratio) were assessed between comorbid and non-comorbid individuals. Absolute neutrophil count, absolute lymphocyte count and hemoglobin levels were also assessed and tested for significance between the two groups. The NLR ratio was increased among those with comorbidities and showed a significant association between the two groups. Absolute neutrophil count was also significant and showed increased levels among those with comorbidities. These may indicate increased risks for coagulopathy amid individuals with comorbidities, although it is notable to mention that d-dimer levels were consistent, and platelets remained normal with insignificant variations between the two groups of individuals. Thus, further research is essential to conclude the possible risks for coagulopathy amid individuals with comorbidities.
Iron deficiency anaemia and its associated risk factors among lactating mothers in Ghana
Authors: K Mensah , G Abbam , FF Gadzeto , L Marfo , S Daud , S Kuntah , SB Bani , HK Dzamesi , FA Apodola , A Badu , FE Chukwurah
Published: January 2025

Background: Anaemia is one of the most common conditions affecting human physiology. Iron deficiency, with or without anaemia, reduces the working capacity of individuals and the entire population. The aim of the study was to establish the prevalence of anaemia; iron deficiency anaemia using serum ferritin levels and factors associated with iron deficiency anaemia among lactating mothers in the district.

Materials & methods: This study was conducted at St. Elizabeth Hospital, Hwidiem in the Ahafo Region of Ghana. Full blood count analysis, serum ferritin, malaria and other measurements such as Body Mass Index (BMI) and diet assessment were done for all the participants. A structured questionnaire was used to collect information on risk factors and demographic characteristics. p>0.05 was considered statistically significant.

Results: The overall prevalence of iron-deficiency anaemia among lactating mothers was 26%. The bivariate analysis showed 13 (50%) positive malaria participants (p = 0.011), 5 (63%) who experience loss of appetite most times (p = 0.003), 17(50%) participants who had no access to regular meal (p = 0.001), four or less antenatal visit (p = 0.004), once a week intake of meat and sea foods (p = 0.001), cereal and legumes intake 2-4 a day (p = 0.044) were associated with iron deficiency anaemia.

Conclusion: IDA prevalence of 26% during lactation may be due to infant iron demands in breast milk. Measures must therefore be put in place for a thorough examination of anaemia in this population which should include the assessment of iron biomarkers and not just haemoglobin levels.
A case report on Nocardia cyriacigeorgica in renal transplant patient
Authors: A Velamuri , R Fatima , SP Eswaran , SR Bezawada
Published: January 2025

Nocardiosis is an opportunistic infection caused by Nocardia species (spp). Nocardia species are ubiquitous environmental saprophytes occurring in the soil, organic matter, and water. A 36-year-old, female, renal transplant recipient presented with cutaneous and cerebral symptoms of disseminated Nocardiosis. Prompt diagnosis and treatment of the case resulted in a favourable outcome. Nocardiosis is an important infection in transplant recipients, which should be diagnosed early so that appropriate therapy can be instituted.
Possible role of morphological features of functional zones of the aorta in the development of thoracic aortic aneurysm
Authors: Suslov Andrey , Strizhkov Alexey , Kirichenko Tatiana , Chumachenko Petr , Khasanova Zukhra , Postnov Anton
Published: January 2025

Aortic aneurysm is the most common disease of the aorta. Modern methods of diagnostics and treatment of aneurysms have allowed to reduce mortality to 21.7%. Aortic aneurysm is characterized by morphological and functional reorganizations of the aorta, leading to changes in the biomechanical characteristics of the vascular wall. Along the aorta, functional zones are distinguished in which a high density of sensitive apparatus is noted. Such receptor zones of the aorta have a specific localization. The main part of sensitive receptors is localized in the middle layer of the aorta. The vascular wall in the area of ​​​​the receptor zones can, apparently, change its lumen somewhat differently than other parts of the aorta, which do not have a high density of receptors. Morphological features of the corresponding segments of the aorta determine the distinctive properties of the biomechanical parameters of the vessel. Receptor zones of the aorta topographically correspond to the areas of the aorta where aneurysm formation is noted.
Un intruso en el discurso de la realidad: El sueño en El pabellón de las peonías y Sueño en el pabellón rojo
Authors: Espinosa-Campos Lucía
Published: January 2025

Este artículo compara el papel de los sueños en las obras literarias clásicas de la literatura china El pabellón de las peonías y Sueño en el pabellón rojo, descubriendo patrones recurrentes en la representación de los sueños. A través de la identificación, la enumeración y la descripción de las características de estos patrones similares en la intervención de los sueños en ambas obras, se propone un método de análisis sistemático que permita reconocer y comprender estos rasgos, así como su impacto en el conjunto de cada obra. Por medio del análisis de la influencia de los sueños en el discurso, en los personajes y en el desarrollo de la trama en sí mismo, se explora si estos atienden a un mecanismo específico y si es posible su normalización. Este estudio, desde una perspectiva crítica en el campo de los estudios sinológicos, persigue establecer una base sólida para la comprensión de los sueños en El pabellón de las peonías y Sueño en el pabellón rojo, revelando la riqueza simbólica y narrativa de estos elementos oníricos en la literatura clásica china.
La variación terminológica conceptual en la traducción de textos normativos del chino al español a través de distintos dominios y parámetros macrotextuales
Authors: Vicens Catalá Carmen
Published: January 2025

Este estudio se centra en los problemas que presenta la variación terminológica conceptual en la traducción jurídica del chino al español, en aras a observar el proceso seguido para la toma de decisiones a nivel microtextual. El lenguaje jurídico está anclado en el lenguaje general, donde la polisemia—que es “a norm in language”—contribuye a que el lenguaje jurídico sea tachado de ambiguo, oscuro y vago. Además, un mismo concepto en la lengua de origen puede tener distintos significados y usos en la lengua de destino, según su contexto y dominio legal. Así, partiremos de la traducción que hemos realizado de diversas leyes de la República Popular China, pertenecientes a distintos dominios. Dichas traducciones constituyen el corpus textual sobre el cual detectamos y analizamos términos problemáticos a causa de su indeterminación, a través de diversos factores situacionales y parámetros macrotextuales para la toma de decisiones a nivel microtextual. El trabajo se fundamenta en el marco de la teoría comunicativa de terminología, por consiguiente, analiza los términos in vivo y las variaciones terminológicas en contexto.
Investigación sobre el papel de las técnicas de dramatización en la comprensión de Chengyu chinos
Authors: Corderi Novoa Modesto
Published: January 2025

Los Chengyu son esenciales para el idioma y la cultura chinos. Condensan la sabiduría antigua en una historia de cuatro caracteres y suelen ser un desafío para los estudiantes internacionales. En esta investigación, utilizamos un enfoque de métodos mixtos que emplea técnicas cuantitativas y cualitativas para investigar cómo el uso del teatro para representar las historias asociadas con los Chengyu ayuda a facilitar la comprensión de los estudiantes sobre ellos. En este artículo, llevamos a cabo una investigación en la Escuela Oficial de Idiomas (EOI) da Coruña en España con 20 estudiantes de entre 14 y 60 años, 13 mujeres, 7 hombres de nivel de idioma chino A1/HSK1. Los grupos de control y experimental estaban compuestos por diez estudiantes que tenían que aprender los mismos cinco Chengyu. Una semana después de haber aprendido los Chengyu, ambos grupos realizaron la misma prueba para evaluar el grado de comprensión de los cinco Chengyu. Los resultados estadísticos muestran que los estudiantes del grupo experimental superaron a los del grupo de control. Por lo tanto, podemos argumentar que el uso del teatro ayudó significativamente a los estudiantes a comprender el Chengyu.
Reseña del libro: "Los estudios asiáticos en España: Análisis, evolución y perspectivas" de Raúl Ramírez Ruiz, Cristina del Prado Higuera y Felipe R. Debasa Navalpotro. Navarra: Editorial Aranzadi/Universidad Rey Juan Carlos, 2023. 384 páginas. ISBN: 978-
Authors: García-Noblejas Sánchez-Cendal Gabriel , Sirui Zhou
Published: January 2025

No hay resumen
Применение алгоритмов машинного обучения на платформе Hadoop для эффективного анализа и классификации мошеннических операций в банковской сфере
Authors: Лихоузов К.И.
Published: January 2025

Материалом для исследования послужили последние научные работы в области машинного обучения, больших данных, алгоритмов в этой сфере и финансов. Были применены ряд методов анализа: монографический метод позволил глубоко погрузиться в тему, оценочный – эффективно анализировать данные, а рефлексивный метод дал возможность критически оценить полученные результаты. Использование машинного обучения в финансовых системах является революционным подходом в обнаружении и предотвращении мошенничества. Метод не только решает сложные задачи, связанные с несбалансированными данными и изменчивостью паттернов, но и позволяет обрабатывать информацию с большой скоростью и точностью. В результате применение таких технологий не только улучшает, а кардинально меняет способы защиты финансовых учреждений от мошеннических атак, обеспечивая высокий уровень безопасности для операций и клиентов.

The article uses the latest research work in the field of machine learning, big data, algorithms in this area and financial activities as research material. A number of analytical methods were applied in the process: the monographic method allowed to dive deeply into the topic, the evaluative method allowed effectively analyze the data, and the reflective method allowed to critically evaluate the findings. The use of machine learning in financial systems is a revolutionary approach to fraud detection and prevention. This method not only solves complex problems associated with unbalanced data and pattern variability, but also allows information to be processed with incredible speed and accuracy. As a result, the use of such technologies is not just improving, but revolutionizing the way financial institutions protect themselves from fraudulent attacks, ensuring the highest level of security for operations and customers.
Прогнозирование и оптимизация нового продукта мобильного оператора
Authors: Селивонин А.Е. , Вечерская С.Е.
Published: January 2025

В статье рассмотрен виртуальный мобильный оператор TeleCom, описана его архитектура. Рассчитано прогнозирование и внедрение чат-бота в архитектуру оператора. Представлен основные моменты по интеграции и масштабируемости чат-бота. Построены графики данных, диаграмма активности чат-бота. Показана значимость прогнозирования и внедрения экспертной системы, которая может успешно функционировать без участия человека-эксперта.

The article considers the virtual mobile operator TeleCom and describes its architecture. The prediction and implementation of a chatbot in the operator’s architecture is calculated. The main points on the integration and scalability of the chatbot are highlighted. Data graphs and a chatbot activity diagram are constructed. The article shows the importance of the expert system forecasting and implementation, which can successfully function without the participation of a human expert.
Advances in diagnosis and management of irritable bowel syndrome
Authors: Mohammed Al Ghamdi Khalid , Alsharif Yusr Ahmed , Buhiji Amna Mohamed , Alshehri Saeed Mofareh , Alsuwilem Osamah Mohammed , Tarazy Roua Jalal , Alrahma Husain Ali , Alshaikh Ruba Ateeq , Alharbi Mubarak Adel , Saleh Sara Jameel Bin , Bawareth Rozana Louai
Published: January 2025

Irritable bowel syndrome (IBS) is a common disorder of the digestive tract manifested by chronic abdominal pain and irregular bowel habits. It has significant negative impacts on quality of life and healthcare resources worldwide. IBS is linked to disrupted signaling between the brain and gut, affecting motility, sensation, and microbiota. Diagnosis is almost always clinical using Rome IV criteria and investigations to exclude organic diseases. IBS is subdivided according to stool patterns, with IBS with diarrhea being most common. Management aims to improve symptoms and quality of life. It includes patient education and reassurance, dietary and lifestyle modifications, pharmacotherapy, and psychological approaches. Dietary interventions involve low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet and use of probiotics. Medications such as rifaximin and linaclotide are prescribed for patients with specific IBS types. Cognitive behavioral therapy (CBT) has proven effective in targeting psychological factors contributing to the condition. This narrative review discusses recent advances in the diagnosis and treatment of IBS. It points to the importance of using a multidisciplinary approach in IBS management to address the underlying complexity of this condition. Further research should be conducted to refine diagnostic and therapeutic strategies of IBS to improve its prognosis.
Lo que fue. Fotografías de una mirada colectiva
Authors:   Universidad de Castilla-La Mancha, Villoria Gomez Aurora , Brito Rodríguez María , Limón Serrano Nieves , Minguito Palomares Álvaro
Published: January 2025

Fotografías de una miraa colectiva
A Garden as a Niche: Botany and Imperial Politics in the Early Nineteenth century Dutch Empire
Authors: Weber Andreas
Published: January 2025

This essay provides a fresh view on early history of the botanical garden in Buitenzorg by zooming in on the activities of the gardens’ first and second directors: Caspar Georg Carl Reinwardt and Carl Ludwig Blume. In particular under Blume’s aegis the garden was under constant threat which eventually led to the temporary closure of the garden in 1826. The essay conceptualizes the garden as a provisional niche, in which collectors, gardeners, merchants, administrators, and plant experts with diverse socio-economic backgrounds and networks came together to negotiate the relationship between botany and imperial politics. Taken together this essay argues that plant science and the garden’s institutional development need to be analyzed as part of a much wider history of colonial management and agricultural exploitation.
Astronomische biografieën
Authors: Baneke David
Published: January 2025

This essay review discusses four biographies of Dutch astronomers:  Kapteyn, Oort, De Sitter, and Fockens. The first three are established names from twentieth century astronomy, the fourth is a forgotten, nineteenth-century talent, whose career never got off the ground. Three of the books were written by ‘amateur’ historians. I shall argue that professional historians should appreciate this group, and their efforts, for what they initiate rather than criticize them for what they omit.
Distribution patterns of the Baraba buzzing grasshopper Angaracris barabensis (Pallas) (Orthoptera: Acrididae)
Authors: Pashkova A. I. , Molodtsov V. V. , Storozhenko S. Yu. , Baturina N. S. , Popova K. V. , Yefremova O. V. , Sergeev M. G.
Published: January 2025

Aim. Angaracris barabensis is widely distributed across the Asian grasslands. It is often qualified as one of the important pests. The aim of the paper is to estimate possible shifts of its distribution relative to global warming. The geographic coordinates of 384 localities were determined for the species. Two different approaches to species distribution modelling (maximum entropy and multidimensional ellipsoid envelope) were used. The general patterns of distribution were described. Several models of the species distribution were generated and compared. The main factors of its distribution are revealed. Ecological modelling predicts opportunity of possible northward shifts of the species range in Central and East Siberia and persistence of areas of possible harmfulness in South Siberia, Mongolia and North China. Our predictions show two opposite trends. In the western and southeastern parts of the species range, suitability of conditions will decrease. In the central and north‐eastern parts, the suitability will remain almost the same or even increase. The comparative analysis shows there are no evident contemporary shifts of range boundaries of A. barabensis associated with global warming per se or this tendency is extremely weak. However, the distribution of suitable conditions can change significantly during the next several decades.
Generative AI to Predict Breast Cancer: Current Approaches, Advancements, and Challenges
Authors: Mohapatra Alma
Published: January 2025

Breast cancer is one of the most prevalent cancers worldwide, with early detection playing a critical role in improving patient outcomes and survival rates. Traditional diagnostic methods, though effective, often face challenges in terms of accessibility, cost, and the need for highly skilled radiologists. Recent advancements in Artificial Intelligence (AI), particularly Generative AI (GAI), have opened new avenues in medical imaging and predictive analysis. Unlike conventional AI models, Generative AI can produce synthetic data that mimics real mammograms, providing a robust solution to data scarcity and enhancing model training.
This paper explores the application of Generative AI, especially Generative Adversarial Networks (GANs) and Variational Autoencoders (VAEs), in predicting breast cancer through synthetic imaging and data augmentation techniques. By generating high-quality synthetic breast cancer imaging data, GAI models can improve diagnostic accuracy and sensitivity. We review recent studies and case examples where Generative AI has demonstrated efficacy in predicting and detecting breast cancer at early stages, often outperforming traditional AI models. In addition, we provide a technical overview of the workflow involved in training and deploying GAI models for breast cancer prediction, highlighting steps from data acquisition and preprocessing to model evaluation.
The findings suggest that while Generative AI holds significant promise in predictive oncology, it also faces challenges related to model interpretability, data bias, and ethical considerations. We discuss these limitations and propose strategies to address them, focusing on the need for diversified data sources, model transparency, and collaboration between data scientists and healthcare professionals. The paper concludes with an outlook on future advancements in Generative AI, including the integration of newer models such as diffusion models, and emphasizes the potential of these technologies to revolutionize cancer diagnostics by providing cost-effective, accessible, and highly accurate predictive tools for breast cancer.
Impact of Early Schooling on Health and Life Style of School Going Children
Authors: Dr Ajay Kumar Sharma Dr.ManjuLata Sharma , DrShefali Sharma ,
Published: January 2025

It is generally accepted that early childhood education improves the educational performance of children. Various studies have reported a wide range of problems in children who started early schooling. These problems include Clinging to parents, nocturnal enuresis, throwing temper tantrums and bruxism. Additionally various other behavioural problems like disturbed or excessive sleeping and feeding difficulties have also been reported in these children. Many prestigious studies have concluded that children who began school at a somewhat earlier age performed less at the beginning of school, showed little or no improvement over the course of their first years of schooling, and functioned at a lesser level in third grade than children who began school at a somewhat later age. Considering the fact that the optimum age at which the schooling should begin has always been the important topic of deliberation amongst the parents as well as policy maker we conducted this observational study to find out impact of early schooling on health and life style of children. We found that those children who started early schooling suffered from various behavioral problems like clinging to parents, bedwetting, temper tantrums and sleep disturbances. We conclude that it is not desirable to send children for any kind of schooling before 3 years of age and parents should prepare children for formal education instead of sending to preparatory school before 3 years.
Mixed Ovarian Tumor with torsion ovary- A unique presentation
Authors: Aggarwal , Lovepreet Kaur K. Kaur, R. Garg , A. Kaur , Sangeeta
Published: January 2025

Ovarian torsion is one of the significant causes of acute abdomen in women. The presentation being vague, non specific and necessitates urgent diagnosis and surgical intervention to salvage the ovary. In the present case, the presence of serous cystadenoma in one ovary and mucinous cystadenocarcinoma in both ovaries was observed alongwith torsion of left ovary.
NEISSERIA MENINGITIDIS NO RIO GRANDE DO SUL: UMA COMPARAÇÃO DA EFETIVIDADE VACINAL SOBRE OS SOROGRUPOS MAIS PREVALENTES
Authors: Faggion Lucatelli Juliana
Published: January 2025

A Neisseria meningitidis provoca doenças invasivas como a meningite e apresenta seis sorogrupos patogênicos. A forma de combater sua propagação é através da vacinação, já implantada desde 2010 no SUS para menores de 1 ano e em 2017 para adolescentes. O objetivo deste trabalho é comparar a efetividade vacinal sobre os sorogrupos e sorotipos mais prevalentes de N. meningitidis no RS. Métodos: A coleta de dados se deu através de banco de dados apresentando os sorogrupos e sorotipos de cada amostra durante o período de 2009 a 2021. Os dados foram analisados através de análise descritiva simples. Resultados: Observando os resultados até 2012 o sorogrupo mais frequente era B e a partir de 2014 passou a ser o C, seguido do W. Já dos 20 diferentes sorotipos conhecidos o 23 foi o mais frequente. Em 2009 e 2010 a frequência de casos em menores de um ano era de 40% e 28,6%, respectivamente. Desde 2010 a frequência do sorogrupo B é a maior em menores de um ano. A partir de 2017, em menores de quinze anos houve uma redução no número de casos por C. Conclusões: Os dados demonstram que a vacinação está sendo efetiva, sendo agora o B o responsável pela maioria de casos em menores de um ano. Nesta patologia não existe imunidade de rebanho. Para que as vacinas sejam ainda mais eficientes, e atinjam a população adequada, um panorama do sorogrupo e sorotipo mais frequentes no RS se fez necessário.
Teaching Grammar: The Intersection of Teacher Stated Beliefs and Classroom Implementation
Authors: Widagsa Rudha , Rahmawan Andi , Tria Agustin Dery , Andrea Andrea
Published: January 2025

This study investigates the intersection between teachers’ stated beliefs regarding grammar instruction and their actual classroom practices, focusing on two experienced English teachers in Yogyakarta, Indonesia. While prior research underscores the influential role of teachers' beliefs in shaping instructional approaches, discrepancies between these beliefs and classroom implementation are frequently observed. This qualitative case study involved two English teachers from a junior high school in Yogyakarta who have completed their undergraduate degrees in English education and have over ten years of teaching experience. Data were collected through semi-structured interviews, classroom observations, and document analysis to explore how teachers' beliefs about teaching grammar align or diverge from their practices. The findings reveal inconsistencies, demonstrating that while both teachers express a preference for implicit, communicative approaches, practical challenges such as large class sizes, curriculum demands, and varied student proficiency often necessitate the use of explicit instruction methods. These results support existing literature that highlights contextual factors as mediators between beliefs and practices. The study emphasizes the need for reflective practices and tailored professional development programs that help teachers align their instructional strategies with their beliefs. This alignment can enhance instructional effectiveness and foster a more cohesive learning environment. Future research should further investigate how professional development and reflective practices can support teachers in bridging the gap between their beliefs and classroom methodologies.
The Facial approximation of the controversial skull attributed to Wolfgang Amadeus Mozart (1756–1791)
Authors: Moraes Cicero , Šindelář Jiří , Habicht Michael E. , Sineo Luca , Beaini Thiago , Varotto Elena , Galassi Francesco Maria
Published: January 2025

Wolfgang Amadeus Mozart (1756–1791) is considered as one of the greatest composers of the Classical Period of music (ca. 1750–1820). Gifted with an unparalleled precocity, which allowed him to play and compose at the highest levels from a very young age, he continued his studies until the end of his life. Despite his prominent status, he was buried in a collective grave and years later his skull was supposedly recovered, reaching the present day surrounded by an atmosphere of mystery and controversy. This study, using a free, open-source, multiplatform software and the available published material, independently seeks to approximate the face of this skull and compare it with previous publications and portraits painted during the composer’s lifetime.
Implementation of Smart Training on Construction Site Safety: A Case Study in Hong Kong
Authors: Chan Yan Wai , Ng Kwan-Keung , Cheung Simon
Published: January 2025

The construction industry has made progress in improving safety controls, but vocational and professional education and training are still necessary to ensure site safety. In the 2022-2023 budget, the Hong Kong government has allocated HK$1.2 billion to The Construction Innovation and Technology Fund (CITF) implementation of advanced construction technologies (ACT) and a smart site safety system (SSSS) and the purpose of this system is to reduce accidents in the construction industry. In September and October of 2023, relevant training courses for the SSSS were introduced on a pilot basis. The industry will have access to a learning platform to participate in these courses. The Hong Kong Institute of Construction (HKIC) developed a training course to introduce the SSSS to the construction industry in Hong Kong. This research paper aims to explain how this training course has been designed. Participants were asked to complete anonymous questionnaires after the first two training classes, and an after-class interview was conducted to evaluate the effectiveness of the training. This paper explores the effectiveness of training and offers suggestions for evaluating training courses for different stakeholders in the industry.
Influence of Seed Priming on Morphological Parameters in Groundnut (Arachis hypogea L.)
Authors: Rout Ankita , Kulkarni C.C. , Monalisa S.P. , Mishra Soumya , Tripathy Seema , Swain Santanu Kumar
Published: January 2025

Background: A study comprising laboratory and field research studies were conducted at the Department of Seed Science and Technology, Faculty of Agricultural Sciences, Siksha ‘O’ Anusandhan (Deemed to be) University, Bhubaneswar in 2022-23 to evaluate the relative effectiveness of different seed priming treatments and soaking duration enhancement to improve groundnut seed production and quality maintenance. The field study was set up using Randomized Block Design (RBD) with three replications and eight priming treatments. For the experiment, groundnut seeds of the Devi variety were procured from a self-help group (SHG) located in the region of Pipili, Puri, Odisha. Methods: Different priming treatments were applied to the seeds, including; Untreated (control, T1), hydro priming (4 hours, T2), 1% Na2HPO4 (4 hours, T3), 1% CaCl2 (4 hours, T4), 1% KCL (4 hours, T5), 0.5% Borax (4 hours, T6), 25 ppm Gibberellic acid (4 hours, T7), 0.5% KNO3 (4 hours, T8). The treatments mentioned above were used for seed priming and seeds were then dried back until their moisture content was the same as before. Result: Plant growth parameters showed that seeds primed with 1% CaCl2 had earlier 50% flowering and maturity, while seeds primed with 25 ppm GA3 had the maximum plant height. Additionally, seeds primed with CaCl2 showed an increase in yield attributing parameters, such as the number of pods per plant, pod weight, number of seeds per pod and test weight of seeds, which increased the yield per plant and per hectare.
Pendidikan Kristen yang Holistik dalam Pembelajaran IPS (Studi Kasus Di Sekolah Menegah Pertama XYZ Lippo Karawaci) [Holistic Christian Education in Social Studies Learning (Case Study at XYZ Lippo Karawaci Junior High School)]
Authors: Purba Rasta Wahyuni , Suwu Selvi Ester
Published: January 2025

Holistic Christian education covers all aspect of student’s potentials in harmony. In fact education oftens times is seen just from particular aspects, intellectual aspect is considered as the most important. This issue can lead to unablity in maximazing the student’s potentials in other aspects. Learning process in social studies class frequently give boredom to the student, somehow learning become so tighten because of the competition who will have the best grade, it makes student will learn due to the examination period. The researcher found this phenomenon when the researcher was doing observation in learning process. In this research is aimed to research how the XYZ junior high school implements the holistic education in social studies learning. Research method was used in this research was qualitative research, specifically a study case by doing depth interview to the teachers, students’ questionnaire and observation. The result of the research shows that the school already implemented the holistic education but not yet comprehensively and maximally. The supportive aspect in implementing of holistic education is the school program as professional development which helped the teacher in implementing the holistic education and the obstacle which was found in implementing the holistic education is too much content of the material in social studies class with limited time.
 
ABSTRACT BAHASA INDONESIA: Pendidikan Kristen yang holistik mencakup aspek keseluruhan pribadi siswa sebagai ciptaan yang utuh. Pada kenyataanya pendidikan sering kali dilihat dari salah satu aspek saja, cenderung mengutamakan aspek kognitif sehingga siswa tidak dapat memaksimalkan potensi lainnya. Pembelajaran di dalam kelas khususnya pelajaran IPS seringkali membosankan bahkan menegangkan karena adanya persaingan untuk memperoleh  nilai  yang paling tinggi, sehingga siswa hanya belajar jika ujian, seperti yang terjadi di sekolah XYZ di Lippo Karawaci khususnya di kelas XI.
Penelitian ini bertujuan untuk mengetahui penerapan pendidikan holistik dalam pembelajaran IPS di sekolah XYZ, serta hal yang menjadi faktor pendukung dan penghambat dalam penerapannya. Metode yang digunakan adalah kualitatif studi kasus dengan menggunakan instrumen, lembar wawancara, lembar observasi dan lembar angket.
Hasil dari penelitian menunjukkan bahwa sekolah ini sudah menerapkan pendidikan yang holistik namun masih ada catatan-catatan yang harus diperhatikan. Hal yang menjadi faktor pendukung dalam penerapan pendidikan yang holistik ialah adanya program Professional development dari sekolah yang membantu guru dalam penerapannya.   Kendala yang ditemukan ialah padatnya materi IPS yang diajarkan guru dengan waktu yang terbatas.
Perceptions paysannes de la dynamique des parcours naturels et stratégies d’adaptation dans la vallée du Mandoul au Tchad
Authors: Mabilo Terei Massa , Bechir Ali Brahim , Mama Adi , Oundanang Koussou Mian , Affossogbe Sedjro Antoine Tranquillin , Dossa Luc Hippolyte
Published: January 2025

Contexte : Dans les pays sahéliens, depuis plus de trois décennies, l’activité pastorale est soumise à des contraintes climatiques et démographiques engendrant une forte dégradation de l’écosystème. Objectif : La présente étude a eu pour objectifs de cerner les perceptions par les éleveurs de la vallée du Mandoul au Tchad des changements climatiques et de leurs incidences sur les pâturages, et de comprendre les stratégies d’adaptation de ces éleveurs. Méthodes : Cette analyse s’est appuyée sur le diagnostic agropastoral. Au total, 205 personnes appartenant à différents groupes d’éleveurs ont été sélectionnés pour cette étude. Cependant, 180 éleveurs ont effectivement participé aux groupes de discussion (focus groups) et 34 autres ont fait objet d’entretiens individuels basés sur un questionnaire préétabli. Résultats : Les résultats ont montré que tous les éleveurs enquêtés perçoivent les changements climatiques à travers la répartition inégale des pluies (88,3 %), une hausse de température (50,5 %) et une plus grande fréquence des vents violents accompagnés de poussières (78,9 %). Ils ont tous déclaré que plusieurs espèces fourragères ont disparu au cours des dix dernières années et que d’autres sont menacées ou en voie de disparition. Ils ont également mentionné l’apparition d’espèces envahissantes de faible valeur pastorale et non appétées par les animaux. Dans ce contexte de vulnérabilité accrue, les stratégies développées par les éleveurs pour leur survie reposent sur la mobilité des troupeaux, la diversification des activités génératrices de revenus et le stockage des résidus de culture pour l’alimentation des animaux pendant la saison sèche. Cependant, selon les éleveurs, ces stratégies ne répondent pas à toutes leurs attentes et montrent des limites, surtout en matière de durabilité. Conclusions : Cette étude fait ressortir la nécessité de la mise en place de stratégies adéquates pour une gestion durable des ressources pastorales dans le Mandoul afin d’assurer la pérennité des espèces végétales tout en soutenant les moyens de subsistance des communautés d'éleveurs.
¿Colaboración anglo-española o resistencia local?
Authors: Gregorio Sainz Silvia
Published: January 2025

En 1813 las referencias a Santander en la correspondencia de Wellington se multiplicaron a raíz de los preparativos para la nueva ofensiva anglo-hispanoportuguesa en España. Al no poder depender de la inadecuada infraestructura terrestre, Wellington recurrió a la Royal Navy para garantizar el suministro al ejército. Era imprescindible entonces un punto de contacto en la costa cantábrica y Santander cumplía los requisitos para convertirse en su base logística. Esa responsabilidad fue difícil de manejar para las autoridades civiles por su impacto en la vida diaria, y la gestión de los problemas surgidos tensó la relación con los aliados. Este artículo examina las referencias a Santander principalmente en los despachos de Wellington, y también las alusiones a la presencia y actuaciones británicas en la ciudad en la documentación local. Su revisión crítica revela la importancia del puerto cántabro en la campaña final de la guerra y sus consecuencias para la población.
La sociedad del control
Authors: Martínez López Diego
Published: January 2025

Entre 1968 y 1972 el Estado franquista sentó las bases estructurales de un entramado represivo centrado en el combate de la subversión social y la disidencia política, un esfuerzo en el que jugaron un papel destacado los servicios militares de inteligencia. El origen de esa pugna y de los mecanismos empleados para su supresión hunde sus raíces en la Guerra Civil y en la reordenación del Ejército realizada en la inmediata posguerra, la cual llevaría a definir y poner en marcha una serie de instrumentos de control interno de las unidades militares que tendrían hondas repercusiones en la sociedad civil. El presente artículo ofrece las primeras conclusiones extraídas del estudio sistemático de los Boletines y notas de información elaborados por los Servicios de Inteligencia a lo largo de la Dictadura, ofreciendo una nueva perspectiva sobre los mecanismos de control social empleados por el régimen durante sus últimos años.
Crisis final del Franquismo. Nuevos enfoques y estudios en torno a la conflictividad y la violencia. Gutmaro Gómez Bravo (coord.). Introducción
Authors: Gómez Bravo Gutmaro
Published: January 2025

Introducción
Tunable type-I band alignment and electronic structure of GaSe/MoSi2N4 van der Waals heterostructure
Authors: Jiang Hongxing , Zhu Xiangjiu , Wang Dandan , Yang Lihua , Liu Yang , Qu Xin , Liu Huilian
Published: January 2025

In this study, we have conducted an investigation on the structural characteristics and electronic properties of van der Waals heterostructures (vdWHs) composed of Gallium selenide (GaSe) and MoSi2N4. The analysis was carried out using first-principles methods. The findings indicate that the heterostructure exhibits stability at standard room temperature and possesses characteristics of an indirect bandgap semiconductor. Interestingly, we observed that the band edges of the heterostructure of monolayer GaSe and MoSi2N4 were able to form a type-I band alignment. Therefore, in the field of optoelectronic devices, GaSe/MoSi2N4 vdWHs can be widely used in light-emitting devices such as diodes. In addition, through the application of an external electric field and in-plane strain, the band edges of GaSe/MoSi2N4 vdWHs can be separated from the GaSe and MoSi2N4 layers, forming a transition from the type-I to type-II band alignment, which is very favorable for realizing effective electron-hole separation. Therefore, GaSe/MoSi2N4 vdWHs have great potential as an adjustable material in optoelectronic applications.