bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S2 from Comprehensive DNA Methylation Profiling of Medullary Thyroid Carcinoma: Molecular Classification, Potential Therapeutic Target, and Classifier System
Authors: Shen Cenkai , Shi Xiao , Wen Duo , Zhang Yuqing , Du Yuxin , Zhang Yu , Ma Ben , Tang Haitao , Yin Min , Huang Naisi , Liao Tian , Zhang Ting-Ting , Kong Chang’e , Wei Wenjun , Ji Qinghai , Wang Yu
Published: January 2024

List of top 30 differentially methylated regions (DMRs) of MTC-C relative to the other two subtypes
Table S1 from Comprehensive DNA Methylation Profiling of Medullary Thyroid Carcinoma: Molecular Classification, Potential Therapeutic Target, and Classifier System
Authors: Shen Cenkai , Shi Xiao , Wen Duo , Zhang Yuqing , Du Yuxin , Zhang Yu , Ma Ben , Tang Haitao , Yin Min , Huang Naisi , Liao Tian , Zhang Ting-Ting , Kong Chang’e , Wei Wenjun , Ji Qinghai , Wang Yu
Published: January 2024

Detailed patient information of the MTC methylation cohort
Supplementary Figure S1 from Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma
Authors: Petrylak Daniel P. , Eigl Bernhard J. , George Saby , Heath Elisabeth I. , Hotte Sebastien J. , Chism David D. , Nabell Lisle M. , Picus Joel , Cheng Susanna Y. , Appleman Leonard J. , Sonpavde Guru P. , Morgans Alicia K. , Pourhosseini Pourya , Wu Ruishan , Standley Laura , Croitoru Ruslan , Yu Evan Y.
Published: January 2024

Supplementary Figure S1. Patient Disposition.
Supplementary Table S1 from Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy
Authors: Zila Nina , Eichhoff Ossia M. , Steiner Irene , Mohr Thomas , Bileck Andrea , Cheng Phil F. , Leitner Alexander , Gillet Ludovic , Sajic Tatjana , Goetze Sandra , Friedrich Betty , Bortel Patricia , Strobl Johanna , Reitermaier René , Hogan Sabrina A. , Martínez Gómez Julia M. , Staeger Ramon , Tuchmann Felix , Peters Sophie , Stary Georg , Kuttke Mario , Elbe-Bürger Adelheid , Hoeller Christoph , Kunstfeld Rainer , Weninger Wolfgang , Wollscheid Bernd , Dummer Reinhard , French Lars E. , Gerner Christopher , Aebersold Ruedi , Levesque Mitchell P. , Paulitschke Verena
Published: January 2024

Characteristics and clinical baseline parameters of melanoma patients in the study.
Supplementary Table S1 from FDA Approval Summary: Alpelisib for PIK3CA-Related Overgrowth Spectrum
Authors: Singh Sonia , Bradford Diana , Li Xiaoxue , Mishra-Kalyani Pallavi S. , Shen Yuan-Li , Wang Lingshan , Zhao Hong , Xiong Ye , Liu Jiang , Charlab Rosane , Kraft Jeffrey , Khasar Sachia , Miller Claudia P. , Rivera Donna R. , Kluetz Paul G. , Pazdur Richard , Beaver Julia A. , Singh Harpreet , Donoghue Martha
Published: January 2024

Distribution and Key Features of PIK3CA mutations and Response to Alpelisib within the Efficacy Population
Trial Protocol 1 from A Phase II Trial of the CD40 Agonistic Antibody Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Confirmed Disease Progression on Anti-PD-1 Therapy
Authors: Weiss Sarah A. , Sznol Mario , Shaheen Montaser , Berciano-Guerrero Miguel-Ángel , Couselo Eva Muñoz , Rodríguez-Abreu Delvys , Boni Valentina , Schuchter Lynn M. , Gonzalez-Cao Maria , Arance Ana , Wei Wei , Ganti Apar Kishor , Hauke Ralph J. , Berrocal Alfonso , Iannotti Nicholas O. , Hsu Frank J. , Kluger Harriet M.
Published: January 2024

Clinical Trial Protocol
Supplementary Fig. S3 from Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy
Authors: Zila Nina , Eichhoff Ossia M. , Steiner Irene , Mohr Thomas , Bileck Andrea , Cheng Phil F. , Leitner Alexander , Gillet Ludovic , Sajic Tatjana , Goetze Sandra , Friedrich Betty , Bortel Patricia , Strobl Johanna , Reitermaier René , Hogan Sabrina A. , Martínez Gómez Julia M. , Staeger Ramon , Tuchmann Felix , Peters Sophie , Stary Georg , Kuttke Mario , Elbe-Bürger Adelheid , Hoeller Christoph , Kunstfeld Rainer , Weninger Wolfgang , Wollscheid Bernd , Dummer Reinhard , French Lars E. , Gerner Christopher , Aebersold Ruedi , Levesque Mitchell P. , Paulitschke Verena
Published: January 2024

Primary melanoma tumor cells of NR display a distinctive immunophenotype.
Supplementary Fig. S2 from Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy
Authors: Zila Nina , Eichhoff Ossia M. , Steiner Irene , Mohr Thomas , Bileck Andrea , Cheng Phil F. , Leitner Alexander , Gillet Ludovic , Sajic Tatjana , Goetze Sandra , Friedrich Betty , Bortel Patricia , Strobl Johanna , Reitermaier René , Hogan Sabrina A. , Martínez Gómez Julia M. , Staeger Ramon , Tuchmann Felix , Peters Sophie , Stary Georg , Kuttke Mario , Elbe-Bürger Adelheid , Hoeller Christoph , Kunstfeld Rainer , Weninger Wolfgang , Wollscheid Bernd , Dummer Reinhard , French Lars E. , Gerner Christopher , Aebersold Ruedi , Levesque Mitchell P. , Paulitschke Verena
Published: January 2024

Enlarged proteomaps results for the tumor cell lysate dataset.
Supplementary Table S3 from Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer
Authors: Wilkerson Avia D. , Parthasarathy Prerana Bangalore , Stabellini Nickolas , Mitchell Carley , Pavicic Paul G. , Fu Pingfu , Rupani Amit , Husic Hana , Rayman Patricia A. , Swaidani Shadi , Abraham Jame , Budd G. Thomas , Moore Halle , Al-Hilli Zahraa , Ko Jennifer S. , Baar Joseph , Chan Timothy A. , Alban Tyler , Diaz-Montero C. Marcela , Montero Alberto J.
Published: January 2024

Selected Reactome Pathways for Figure 2A
Supplementary Table S2 from Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer
Authors: Wilkerson Avia D. , Parthasarathy Prerana Bangalore , Stabellini Nickolas , Mitchell Carley , Pavicic Paul G. , Fu Pingfu , Rupani Amit , Husic Hana , Rayman Patricia A. , Swaidani Shadi , Abraham Jame , Budd G. Thomas , Moore Halle , Al-Hilli Zahraa , Ko Jennifer S. , Baar Joseph , Chan Timothy A. , Alban Tyler , Diaz-Montero C. Marcela , Montero Alberto J.
Published: January 2024

Pre-treatment core needle biopsy sites in patients with evaluated tumors
Supplementary Table S1 from Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer
Authors: Wilkerson Avia D. , Parthasarathy Prerana Bangalore , Stabellini Nickolas , Mitchell Carley , Pavicic Paul G. , Fu Pingfu , Rupani Amit , Husic Hana , Rayman Patricia A. , Swaidani Shadi , Abraham Jame , Budd G. Thomas , Moore Halle , Al-Hilli Zahraa , Ko Jennifer S. , Baar Joseph , Chan Timothy A. , Alban Tyler , Diaz-Montero C. Marcela , Montero Alberto J.
Published: January 2024

Representativeness of Study Participants
Supplementary Figure S5 from Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer
Authors: Wilkerson Avia D. , Parthasarathy Prerana Bangalore , Stabellini Nickolas , Mitchell Carley , Pavicic Paul G. , Fu Pingfu , Rupani Amit , Husic Hana , Rayman Patricia A. , Swaidani Shadi , Abraham Jame , Budd G. Thomas , Moore Halle , Al-Hilli Zahraa , Ko Jennifer S. , Baar Joseph , Chan Timothy A. , Alban Tyler , Diaz-Montero C. Marcela , Montero Alberto J.
Published: January 2024

Using single cell-RNA sequencing data from other investigations of response to anti-PD-1 chemo-immunotherapy in advanced TNBC to validate association of IGHG1 expression with treatment response.
Supplementary Figure S1 from Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer
Authors: Wilkerson Avia D. , Parthasarathy Prerana Bangalore , Stabellini Nickolas , Mitchell Carley , Pavicic Paul G. , Fu Pingfu , Rupani Amit , Husic Hana , Rayman Patricia A. , Swaidani Shadi , Abraham Jame , Budd G. Thomas , Moore Halle , Al-Hilli Zahraa , Ko Jennifer S. , Baar Joseph , Chan Timothy A. , Alban Tyler , Diaz-Montero C. Marcela , Montero Alberto J.
Published: January 2024

Heat map of Reactome Pathway Enrichment (Top 25, Bottom 25, and selected pathways) by pairwise comparison of radiographic response category (CR, PR, SD, PD)
Supplementary Table S1 from PHF6-altered T-ALL Harbor Epigenetic Repressive Switch at Bivalent Promoters and Respond to 5-Azacitidine and Venetoclax
Authors: Pinton Antoine , Courtois Lucien , Doublet Charlotte , Cabannes-Hamy Aurélie , Andrieu Guillaume , Smith Charlotte , Balducci Estelle , Cieslak Agata , Touzart Aurore , Simonin Mathieu , Lhéritier Véronique , Huguet Françoise , Balsat Marie , Dombret Hervé , Rousselot Philippe , Spicuglia Salvatore , Macintyre Elizabeth , Boissel Nicolas , Asnafi Vahid
Published: January 2024

PHF6 variant allelic frequencies of the additional 37 non protocolar paired diagnosis/relapsed PHF6ALT patients.
Data from FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
Authors: Pifer Phillip M. , Yang Liangpeng , Kumar Manish , Xie Tongxin , Frederick Mitchell , Hefner Andrew , Beadle Beth , Molkentine David , Molkentine Jessica , Dhawan Annika , Abdelhakiem Mohamed , Osman Abdullah A. , Leibowitz Brian J. , Myers Jeffrey N. , Pickering Curtis R. , Sandulache Vlad C. , Heymach John , Skinner Heath D.
Published: January 2024

AbstractPurpose:
Radiation and platinum-based chemotherapy form the backbone of therapy in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). We have correlated focal adhesion kinase (FAK/PTK2) expression with radioresistance and worse outcomes in these patients. However, the importance of FAK in driving radioresistance and its effects on chemoresistance in these patients remains unclear.
Experimental Design:
We performed an in vivo shRNA screen using targetable libraries to identify novel therapeutic sensitizers for radiation and chemotherapy.
Results:
We identified FAK as an excellent target for both radio- and chemosensitization. Because TP53 is mutated in over 80% of HPV-negative HNSCC, we hypothesized that mutant TP53 may facilitate FAK-mediated therapy resistance. FAK inhibitor increased sensitivity to radiation, increased DNA damage, and repressed homologous recombination and nonhomologous end joining repair in mutant, but not wild-type, TP53 HPV-negative HNSCC cell lines. The mutant TP53 cisplatin-resistant cell line had increased FAK phosphorylation compared with wild-type, and FAK inhibition partially reversed cisplatin resistance. To validate these findings, we utilized an HNSCC cohort to show that FAK copy number and gene expression were associated with worse disease-free survival in mutant TP53, but not wild-type TP53, HPV-negative HNSCC tumors.
Conclusions:
FAK may represent a targetable therapeutic sensitizer linked to a known genomic marker of resistance.
Data from Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma
Authors: Petrylak Daniel P. , Eigl Bernhard J. , George Saby , Heath Elisabeth I. , Hotte Sebastien J. , Chism David D. , Nabell Lisle M. , Picus Joel , Cheng Susanna Y. , Appleman Leonard J. , Sonpavde Guru P. , Morgans Alicia K. , Pourhosseini Pourya , Wu Ruishan , Standley Laura , Croitoru Ruslan , Yu Evan Y.
Published: January 2024

AbstractPurpose:
Effective treatment of locally advanced or metastatic urothelial carcinoma (mUC) remains an unmet need. Antibody–drug conjugates (ADC) providing targeted drug delivery have shown antitumor activity in this setting. AGS15E is an investigational ADC that delivers the cytotoxic drug monomethyl auristatin E to cells expressing SLITRK6, a UC-associated antigen.
Patients and Methods:
This was a multicenter, single-arm, phase I dose-escalation and expansion trial of AGS15E in patients with mUC (NCT01963052). During dose escalation, AGS15E was administered intravenously at six levels (0.10, 0.25, 0.50, 0.75, 1.00, 1.25 mg/kg), employing a continual reassessment method to determine dose-limiting toxicities (DLT) and the recommended phase II dose (RP2D) for the dose-expansion cohort. The primary objective was to evaluate the safety and pharmacokinetics of AGS15E in patients with and without prior chemotherapy and with prior checkpoint inhibitor (CPI) therapy. Best overall response was also examined.
Results:
Ninety-three patients were recruited, including 33 patients previously treated with CPI. The most common treatment-emergent adverse events were fatigue (54.8%), nausea (37.6%), and decreased appetite (35.5%). Peripheral neuropathy and ocular toxicities occurred at doses of ≥0.75 mg/kg. AGS15E increased in a dose-proportional manner after single- and multiple-dose administration; accumulation was low. Five DLT occurred from 0.50 to 1.25 mg/kg. The RP2D was assessed at 1.00 mg/kg; the objective response rate (ORR) was 35.7% at this dose level. The ORR in the total population and CPI-exposed subgroup were 18.3% and 27.3%, respectively.
Conclusions:
DLT with AGS15E were observed at 0.75, 1.00, and 1.25 mg/kg, with an RP2D of 1.00 mg/kg being determined.
Data from Olaparib plus Durvalumab, with or without Bevacizumab, as Treatment in PARP Inhibitor-Naïve Platinum-Sensitive Relapsed Ovarian Cancer: A Phase II Multi-Cohort Study
Authors: Drew Yvette , Kim Jae-Weon , Penson Richard T. , O'Malley David M. , Parkinson Christine , Roxburgh Patricia , Plummer Ruth , Im Seock-Ah , Imbimbo Martina , Ferguson Michelle , Rosengarten Ora , Steeghs Neeltje , Kim Min Hwan , Gal-Yam Einav , Tsoref Daliah , Kim Jae-Hoon , You Benoit , De Jonge Maja , Lalisang Roy , Gort Eelke , Bastian Sara , Meyer Kassondra , Feeney Laura , Baker Nigel , Ah-See Mei-Lin , Domchek Susan M. , Banerjee Susana
Published: January 2024

AbstractPurpose:
Early results from the phase II MEDIOLA study (NCT02734004) in germline BRCA1- and/or BRCA2-mutated (gBRCAm) platinum-sensitive relapsed ovarian cancer (PSROC) showed promising efficacy and safety with olaparib plus durvalumab. We report efficacy and safety of olaparib plus durvalumab in an expansion cohort of women with gBRCAm PSROC (gBRCAm expansion doublet cohort) and two cohorts with non-gBRCAm PSROC, one of which also received bevacizumab (non-gBRCAm doublet and triplet cohorts).
Patients and Methods:
In this open-label, multicenter study, PARP inhibitor-naïve patients received olaparib plus durvalumab treatment until disease progression; the non-gBRCAm triplet cohort also received bevacizumab. Primary endpoints were objective response rate (ORR; gBRCAm expansion doublet cohort), disease control rate (DCR) at 24 weeks (non-gBRCAm cohorts), and safety (all cohorts).
Results:
The full analysis and safety analysis sets comprised 51, 32, and 31 patients in the gBRCAm expansion doublet, non-gBRCAm doublet, and non-gBRCAm triplet cohorts, respectively. ORR was 92.2% [95% confidence interval (CI), 81.1–97.8] in the gBRCAm expansion doublet cohort (primary endpoint); DCR at 24 weeks was 28.1% (90% CI, 15.5–43.9) in the non-gBRCAm doublet cohort (primary endpoint) and 74.2% (90% CI, 58.2–86.5) in the non-gBRCAm triplet cohort (primary endpoint). Grade ≥ 3 adverse events were reported in 47.1%, 65.6%, and 61.3% of patients in the gBRCAm expansion doublet, non-gBRCAm doublet, and non-gBRCAm triplet cohorts, respectively, most commonly anemia.
Conclusions:
Olaparib plus durvalumab continued to show notable clinical activity in women with gBRCAm PSROC. Olaparib plus durvalumab with bevacizumab demonstrated encouraging clinical activity in women with non-gBRCAm PSROC. No new safety signals were identified.
Figure S4 from Signaling Pathway Alterations Driven by BRCA1 and BRCA2 Germline Mutations are Sufficient to Initiate Breast Tumorigenesis by the PIK3CAH1047R Oncogene
Authors: Bhat-Nakshatri Poornima , Khatpe Aditi S. , Chen Duojiao , Batic Katie , Mang Henry , Herodotou Christopher , McGuire Patrick C. , Xuei Xiaoling , Erdogan Cihat , Gao Hongyu , Liu Yunlong , Sandusky George , Storniolo Anna Maria , Nakshatri Harikrishna
Published: January 2024

Expression pattern of T cells and macrophage associated genes in BRCA1 or BRCA2 mutation carriers compared to non-carriers.
Data from Signaling Pathway Alterations Driven by BRCA1 and BRCA2 Germline Mutations are Sufficient to Initiate Breast Tumorigenesis by the PIK3CAH1047R Oncogene
Authors: Bhat-Nakshatri Poornima , Khatpe Aditi S. , Chen Duojiao , Batic Katie , Mang Henry , Herodotou Christopher , McGuire Patrick C. , Xuei Xiaoling , Erdogan Cihat , Gao Hongyu , Liu Yunlong , Sandusky George , Storniolo Anna Maria , Nakshatri Harikrishna
Published: January 2024

Abstract
Single-cell transcriptomics studies have begun to identify breast epithelial cell and stromal cell specific transcriptome differences between BRCA1/2 mutation carriers and non-carriers. We generated a single-cell transcriptome atlas of breast tissues from BRCA1, BRCA2 mutation carriers and compared this single-cell atlas of mutation carriers with our previously described single-cell breast atlas of healthy non-carriers. We observed that BRCA1 but not BRCA2 mutations altered the ratio between basal (basal-myoepithelial), luminal progenitor (luminal adaptive secretory precursor, LASP), and mature luminal (luminal hormone sensing) cells in breast tissues. A unique subcluster of cells within LASP cells is underrepresented in case of BRCA1 and BRCA2 mutation carriers compared with non-carriers. Both BRCA1 and BRCA2 mutations specifically altered transcriptomes in epithelial cells which are an integral part of NFκB, LARP1, and MYC signaling. Signaling pathway alterations in epithelial cells unique to BRCA1 mutations included STAT3, BRD4, SMARCA4, HIF2A/EPAS1, and Inhibin A signaling. BRCA2 mutations were associated with upregulation of IL6, PDK1, FOXO3, and TNFSF11 signaling. These signaling pathway alterations are sufficient to alter sensitivity of BRCA1/BRCA2-mutant breast epithelial cells to transformation as epithelial cells from BRCA1 mutation carriers overexpressing hTERT + PIK3CAH1047R generated adenocarcinomas, whereas similarly modified mutant BRCA2 cells generated basal carcinomas in NSG mice. Thus, our studies provide a high-resolution transcriptome atlas of breast epithelial cells of BRCA1 and BRCA2 mutation carriers and reveal their susceptibility to PIK3CA mutation-driven transformation.
Significance:
This study provides a single-cell atlas of breast tissues of BRCA1/2 mutation carriers and demonstrates that aberrant signaling due to BRCA1/2 mutations is sufficient to initiate breast cancer by mutant PIK3CA.
Sua vida com Benito traduzida: banalização do fascismo e recepção no Brasil das memórias de Raquel Mussolini
Authors: Bianconi Leonardo Rossi , Santurbano Andrea
Published: January 2024

Em 15 de fevereiro de 1949 o suplemento literário Autores e Livros, do jornal A manhã do Rio de Janeiro, publicou uma longa resenha da tradução das memórias de Raquel Mussolini, intitulada Minha vida com Benito, publicada em 1948 pela editora Instituto Progresso Editorial (IPÊ), integrando a Coleção Meridiano, que propunha uma seleção de livros para a formação de uma biblioteca de documentos históricos. Esta coleção traz ainda obras como a de Carmine Senise, chefe da polícia de Mussolini; as memórias Dino Alfieri, embaixador italiano na Alemanha que organizou o encontro entre Hitler e Mussolini; entre outros. Neste artigo pretendemos discutir a relação entre essa escolha tradutória e suas possíveis ligações entre a comunidade italiana no Estado de São Paulo e o fascismo, na Itália e no Brasil. Para isso explicitamos as revisões da figura de Benito Mussolini e as banalizações do fascismo no léxico e na semântica desses textos dos primeiro anos do pós Segunda Guerra, dando atenção especial à construção do Benito “pai de família” e das atenuações dos crimes fascistas nas memórias de Raquel Mussolini.  O intuito é de trazer à tona os possíveis objetivos – mercadológicos, ideológicos e pessoais – dos editores do IPÊ, principalmente dos dissidentes do regime fascista exilados no Brasil: Francesco Malgeri e Luigi Federzoni.
Recepção, tradição e tradução itálicas do De mulieribus claris de Giovanni Boccaccio
Authors: Baggio Adriana Tulio
Published: January 2024

De mulieribus claris (DMC) é uma coletânea de biografias de mulheres escrita por Giovanni Boccaccio entre 1360 e 1370. A obra conheceu grande fortuna do século XIV ao XVI, sendo depois relativamente esquecida até seu resgate no século XIX a partir de uma edição da tradução trecentista em vulgar italiano realizada por Donato Albanzani. Entendendo a relevância desse percurso para a tradição da obra, este artigo traça um panorama de sua recepção no contexto itálico a partir de três aspectos: os estudos em torno das fases redacionais da composição, os momentos de maior produção e circulação de testemunhos, e as iniciativas de tradução ao italiano, com destaque para a de Albanzani na edição de Giacomo Manzoni. O trabalho discute também a possível obliteração da edição manzoniana, o que teria levado à reiteração de equívocos quanto à datação da tradução de Albanzani, e propõe uma reflexão sobre os percalços da transmissão do DMC à luz do conceito de transmissão ativa e caracterizante de Vittore Branca (1958).
As edições das traduções da Commedia dantesca no Brasil do século XX: tradutores e prefaciadores
Authors: Cechinel Fernanda Moro , Gaspari Silvana De
Published: January 2024

A obra Commedia, escrita pelo florentino Dante Alighieri provavelmente no início do século XIV, na ainda não unificada Itália, teve sua primeira versão pública traduzida para o português do Brasil, acredita-se, por volta dos anos 1843, na cidade do Rio de Janeiro, a partir da obra Ramalhete poético do parnaso italiano, do médico, poeta e tradutor Luiz Vicente De Simoni (HEISE, 2007). No entanto, foi no século XX que a obra ganhou diversas traduções e edições em solo brasileiro. Este artigo visa dar continuidade à publicização de alguns dos resultados obtidos na pesquisa, em nível de doutorado, que está sendo desenvolvida no Programa de Pós-Graduação em Literatura (PPGLit) da Universidade Federal de Santa Catarina (UFSC), com bolsa Capes/DS. Em linhas gerais, a pesquisa versa sobre o papel de alguns paratextos (GENETTE, 2009), a saber: prefácio, posfácio, quarta capa e orelha, na leitura de uma obra literária. Contudo, nosso objetivo com este texto será apresentar um panorama das edições brasileiras da Commedia dantesca no século XX, tendo por base seus tradutores e prefaciadores. Nesta etapa da pesquisa, selecionamos 13 edições, que foram catalogadas pelo Dicionário de Literatura Italiana Traduzida (DLIT). Para alcançarmos tal intento, primeiramente, apresentaremos uma brevíssima reflexão sobre o lugar ocupado pela palavra escrita na construção da Itália unificada, bem como o papel da palavra escrita e traduzida na consolidação do mercado editorial no Brasil. Em seguida, com base nas informações obtidas a respeito dos tradutores e prefaciadores coletadas, em sua maioria, através dos materiais paratextuais presentes nas próprias edições pesquisadas, buscaremos traçar um perfil inicial dessas publicações, pensando nos pontos de contato e nas divergências existentes entre elas.
O Ato Autobiográfico como Estratégia: O caso dos pintores italianos da primeira metade do século XX
Authors: Rocco Renata , Murari Victor Tuon
Published: January 2024

O ato autobiográfico é parte de uma estratégia utilizada pelos artistas modernos como forma de assegurar que sua visão dos acontecimentos seja preservada e julgada no futuro. Para que tal estratégia tenha sucesso, os artistas devem estabelecer uma relação de confiança com seus leitores, a fim de que possam garantir que sua versão dos fatos seja considerada a mais coerente e verdadeira.  Com este artigo, propomos discutir alguns aspectos dos escritos autobiográficos de quatro pintores italianos: Carlo Carrà (La Mia Vita, 1943), Gino Severini (Tutta la vita di un pittore, 1946), Massimo Campigli (Scrupoli,1955) e Giorgio De Chirico (Memorie della mia Vita, 1960), trazendo à luz pontos de convergência e divergências entre eles. A escolha pelos quatro artistas se baseou na atuação dos mesmos durante o período fascista e nas relações estabelecidas com agremiações proeminentes, como: o Futurismo, a Pintura Metafísica, a Pintura Mural e os "Italianos de Paris" e por suas atividades enquanto teóricos da arte.
Natureza como Personagem nas Narrativas de A Cidade do Vento e Elias Portolu de Grazia Deledda
Authors: Santos William Soares dos
Published: January 2024

Este artigo tem como objetivo investigar o uso da descrição paisagística e da apropriação de elementos da natureza como personagem nos romances A cidade do vento e Elias Portolu, de Grazia Deledda (1871-1936). De caráter hermenêutico (GADAMER, 2003), é realizado a partir de uma perspectiva sociointeracional do discurso (GUMPERZ, 1982) e da leitura como um processo que conjuga saberes esquemáticos e sistêmicos (WIDDOWSON, 1984, 1993; SANTOS, 2022a, 2022b). A análise investiga como em A cidade do vento a natureza é um de seus principais personagens. O vento, que já aparece no título do livro, é uma de suas forças motrizes: é ele que movimenta e rege a vida das pessoas da inominável cidade onde se passa a trama e pode ser lido como uma metáfora do destino, mas, também, como a força que rege os ciclos da vida. Na leitura de Elias Portolu, a análise foca em como alguns dos elementos que parecem querer conduzir Elias Portolu (personagem central da trama) ao caminho da felicidade surgem na forma da natureza em si mesma, através das minuciosas descrições de bosques, dos prados e de outros elementos da paisagem sarda, ou pelo pensamento representativo de uma sabedoria primitiva, muito ligada às forças da natureza, que pode ser anterior ao Cristianismo, ou mesmo ao pensamento clássico, e que sobrevive na ilha da Sardenha, tal como ela é representada por Deledda em sua narrativa, por meio de personagens como o de zio Martinu. A leitura dos dois romances propostos aponta para a percepção de que Grazia Deledda utiliza a natureza como personagem em suas narrativas em três níveis: 1) o nível da descrição detalhada do próprio elemento da natureza; 2) o da natureza, refletindo o estado emocional dos personagens e; 3) o nível em que o personagem entra em simbiose com a natureza.
Alegorias dantescas e mitos ovidianos no canto XXV do Inferno, da Divina Comédia
Authors: Bosquesi Gisele de Oliveira
Published: January 2024

O presente trabalho tem como objetivo apresentar um estudo do diálogo intertextual entre o canto XXV do inferno da Divina Comédia e os personagens mitológicos cuja fonte remonta à obra do poeta latino Ovídio, autor de As Metamorfoses. Neste canto, em que o autor italiano traz marcas explícitas da retomada intertextual, as figuras mitológicas de Caco, Cadmo e Aretusa aparecem, cada uma a seu modo, como paradigmas de um modelo que Dante, assim o declara, deseja superar. Sendo assim, ao construir a narrativa do fosso dos ladrões, no círculo dos fraudulentos, o canto em questão focaliza dois penitentes sendo metamorfoseados em meio a serpentes, e o autor florentino, enquanto utiliza alguns procedimentos e temas ovidianos procura intensificar seus efeitos, polemizando com o autor latino. Dessa forma, baseando-nos nos estudos precedentes feitos por Curtius (2013), Ledda (2015) e Carney (2012), buscaremos ilustrar como a polêmica intencional com Ovídio e a dantesca exploração poética do horror corporal já presente no poeta latino pode funcionar alegoricamente como um comentário de Dante acerca da concepção de poesia na Idade Média e de seu próprio processo criativo.
L’influenza della lingua materna nell’acquisizione delle preposizioni semplici in italiano come lingua seconda
Authors: Sharafutdinova Elena
Published: January 2024

A aquisição das preposições constitui um dos aspectos mais difíceis da gramática italiana (KATERINOV, 1975), e foi constatado que a transferência afeta o aprendizado de preposições, que é mediado por vários fatores, inclusive a L1, a duração da intervenção didática, o tipo de tarefa (JARVIS, 2000) e o gênero dos aprendizes (LLACH, 2010). Concentrando-se em uma população de 48 alunos estadunidenses de graduação aprendizes de italiano, entre 18 e 22 anos, igualmente distribuídos quanto ao gênero masculino e feminino e à L1 (n=24 falantes nativos monolíngues de inglês e n=24 falantes bilíngues de espanhol-inglês), esse estudo examinou a influência da respectiva L1 no uso das preposições em italiano L2. Comparou-se também o desempenho dos alunos em diferentes níveis de proficiência para avaliar o efeito do tempo de exposição à L2 na aquisição de preposições em italiano. Além disso, o estudo verificou se os resultados da aprendizagem foram influenciados por diferenças de gênero. Para avaliar o conhecimento dos alunos quanto às preposições da L2 e os tipos de transferência da L1, foram empregadas tarefas de tradução, preenchimento de lacunas, múltipla escolha e julgamento de gramaticalidade. O estudo demonstrou que tanto o tipo de L1 quanto o nível de competência na L2 são fatores que influenciam a aquisição de preposições em italiano L2. Por outro lado, o gênero não parece desempenhar uma função significativa no processo. A análise de erros comprovou que a influência do transfer negativo da L1 diminui com o aumento do nível de proficiência na L2. Por fim, os padrões de transferência e os resultados da aprendizagem não são aparentemente influenciados pelos tipos de tarefas.
Diaspora Modern
Authors: Dickerman Leah
Published: January 2024

Diaspora is a defining condition of the history of the past century, a prehistory to our disastrous moment in time and also the foundation of our political landscape. Yet it is notably absent in much art-historical discussion of modernism, despite the fact that the experiences of diaspora and migration are often embedded in the lives of modernist artists and other actors; in the formations, networks, and dispersals of modernist institutions and group affiliations; and in the deployment of characteristically modernist artistic strategies (temporal fragmentation, collage, montage, and the readymade) that manifest a dialectical entanglement of self and other. This essay ponders the disconnect between the historical structures of modernism in art and its theorization, and considers the questions: Can diaspora and diasporic thinking help further our understanding of the twentieth century in art? Can it help us in reconsidering modernism from a diasporic perspective today? As prompts for further thought, the text considers four historical episodes in which ideas of diaspora, modernity, and modernism are entwined: W.E.B. Du Bois and the First Universal Races Congress in London 1911; Georg Simmel, Du Bois, and Alain Locke in Berlin and the emergence of a matrix of modern sociological thinking; Mikhail Bakhtin in exile in Kazakhstan and the formation of his dialogical philosophy of language; and Aaron Douglas and Meyer Shapiro at the First American Artists’ Congress in 1936 and in the pages of Art Front.
Why Afro Asia
Authors: Kee Joan
Published: January 2024

If postcolonial thinking involves considering art history for a “global majority,” a term invoked by an astonishingly wide range of sources from advocates of Zambian independence in pre-1964 Rhodesia to champions of anti-racist language in post-2020 London, the concept of Afro Asia assumes special urgency. Suggestive not only of the world's population, of which over three-quarters call Asia and Africa home, but also of a supermajority deprived of social and cultural autonomy, Afro Asia compels serious consideration of questions joining different iterations of global-majority life. Three principles in particular emerged through the Asian-African (“Bandung”) Conference of 1955: self-determination, coexistence, and sovereignty. Refracted through the works of Sybil Atteck, Senga Nengudi, Sadamasa Motonaga, and Obiora Udechukwu, these terms move well beyond political recognition, transnational solidarity, and isolationist conceptions of autonomy. Self-determination in this context involves deferring to how the artwork inheres as a self-sufficient entity so that it might fully exercise the privileges of sovereignty, including the right to prioritize open interdependence above closed competition as the basis of coexistence. Requiring attention that itself amounts to an active redistribution of the scarce resource of time, such artwork sovereignty might be described as an assertion of dignity exceeding that conferred by institutional and critical recognition alone.
Hont and Koselleck on the Crisis of Authority
Authors: Andersen Lasse S.
Published: January 2024

This paper examines the reception of Reinhart Koselleck’s Kritik und Krise by the intellectual historian István Hont. Relying on hitherto unpublished manuscripts, it argues that the later work of Hont can be seen as a critical response to Koselleck and his characterisation of the crisis of modern politics as a crisis of political authority.
Experience versus Recollection: Reinhart Koselleck and Aleida Assmann on Collective Memory
Authors: Ferdinand Jan
Published: January 2024

Since the 1990s, Reinhart Koselleck has been one of the critics of the concept of collective memory. This includes contributions to practical debates on the one hand and reflections on a more theoretical level on the other. In contrast, with her concept of cultural memory, Aleida Assmann has taken a more positive view of the concept of collective memory. She defends this concept against Koselleck’s critical remarks, referring to him as an implicit addressee of her reflections. This essay takes this disagreement as an opportunity to look more closely at the ‘dialogue’ between them by addressing three overlapping aspects, primarily on a theoretical level: the distinction between experience and recollection, the collective conditions of recollection, and the opposition between history of memory and memory of history.
Growing up in a Ukrainian Bilingual Community: Families’ Daily Practices and Educational Environment
Authors: Shevchuk-Kliuzheva Olha
Published: January 2024

The article analyses the language situation in Ukraine before the beginning of Russian military aggression in February 2022. The data reflect the language practices of Kyiv families with preschool age children. The sociolinguistic study shows the use of different languages, primarily Ukrainian and Russian, in families raising children of this age group. The author traced the correlation between parents' language behaviour and children's language practices. This article examines bilingualism in the context of the daily language practices of children and families. The author pays attention to the sociolinguistic aspects of the Ukrainian language used in the formal and non-formal communication of Kyiv's preschool children.
Language Consciousness and Ukrainian Students’ Attitudes Towards the Ukrainian Language in a Time of War
Authors: Yaremko Liliya , Levchuk Paweł
Published: January 2024

By applying the survey method, the article presents and summarizes the theoretical questions of language policy, the language consciousness of students and their attitudes towards the Ukrainian language both before and after the start of the current Russo–Ukrainian war. Students from four universities took part in the survey: Kyiv National Linguistic University, Ivan Franko National University of L'viv, V. N. Karazin Kharkiv National University, and Yuriy Fedkovych National University of Chernivtsi.
The Role of Conceptualization in Human Cognitive Activity
Authors: Terniievska Yevheniia
Published: January 2024

The article analyzes the cognitive process of conceptualization, which is the process and the result of the mental construction of objects and phenomena. Conceptualization consists of the structuring of knowledge the awareness of specific information. Concepts, which are the result of conceptualization, form a separate system of interrelationships and subordination and thus compose the conceptosphere of national culture. A single concept can be expressed in several ways and at the same time a single word can express different concepts. The article emphasizes that the study of conceptualization strengthens the understanding of the role of concepts in forming a picture of the world. The result of conceptualization is not just a list of formed concepts, but also a conceptosphere as a system which includes both concepts and the connections between them.
The State of Polish Language Learning in Ukraine During the War (Based on a Survey of Students and Teachers) 2022–2023
Authors: Goncharenko Bogdana , Yakovenko Yanina
Published: January 2024

This article is devoted to the study of the state of Polish language learning in Ukraine during the war of 2022–2023. The author analyses official documents, language policy, language practice and social responses to the impact of the war on Polish language learning in Ukraine and its current state. This research will help to better understand the relationship between the war and the Polish language in the context of Ukraine, particularly in the Kyiv region. The research included the collection of data from various sources, including educational institutions and surveys of Polish language learners and teachers. The data were analysed using both quantitative and qualitative methods.
Computational Analysis of Printed Arabic Text Database for Natural Language Processing
Authors: Bouressace Hassina
Published: January 2024

A frequency dictionary of printed Arabic text is essential for natural language processing. It includes 1,251 XML files of Arabic documents collected from ten newspapers and magazines from different countries and created as the PATD database. A total of 2,344 articles were created with various structures: open vocabulary, multi-font, multi-size, and multi-style text. From these articles, 1,102,078 tokens, 19,926 sentences, and 1,000,000 words were extracted. This dictionary provides detailed information for each word, including English equivalents, usage statistics, usage distribution, and the most widely used terms. A thematic vocabulary list of the top words on various topics is also provided. This frequency dictionary is a useful resource of modern Arabic vocabulary for various specialists, students, and learners. The frequency dictionary is freely available to interested researchers on the webpage.
Studying Polish in the Higher Education Institutions of the Donetsk Region of South-Eastern Ukraine: History, Current State, Problems, and Prospects
Authors: Kolhan Olena , Kolhan Tetiana , Padalka Ruslana
Published: January 2024

The functioning of the Polish language in higher education institutions in the Donetsk region of South–Eastern Ukraine is the main focus of our research. The history of the study of Polish in the region is analysed, in particular at the Donbas State Pedagogical University, where Polish has been taught since 2020. The main problems facing the development of Polish language study in the region and higher education institutions are examined, and the prospects for promoting the development of Polish language study are outlined.
Język ukraiński w polskiej przestrzeni publicznej po agresji rosyjskiej na Ukrainę w 2022 roku
Authors: Levchuk Paweł
Published: January 2024

Artykuł przedstawia zmiany w funkcjonowaniu i statusie języka ukraińskiego w Polsce od czasu rozpoczęcia inwazji Rosji na Ukrainę w lutym 2022 roku. Punktem odniesienia jest autorski artykuł opublikowany w roku 2021 w "Cognitive Studies | Études cognitives" o obecności języka ukraińskiego w polskiej przestrzeni publicznej. Artykuł przedstawia zmiany w edukacji, medycynie, informacji, rozrywce i innych sferach. Ponadto zawiera wyniki badań socjolingwistycznych przeprowadzonych wśród migrantów na temat obecności języka ukraińskiego w Polsce.
Statistical analysis of the storage time of finished product infusion
Authors: Yuhan Zhang , Qingqing Yi , Zhihui Cao , Yongjun Meng , Guowei Jiang
Published: January 2024

Objective

This retrospective study determined the storage time of finished infusion in each hospital ward and assessed whether the storage time of finished infusion was within an acceptable range.

Methods

The research object was the finished infusion (one bag of infusion with only one drug) that is centrally dosed at the Pharmacy Intravenous Admixture Service (PIVAS) of Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences. We used an automatic scanner to assess the placement time of finished infusion products in various wards of the hospital. We classified the drugs used in various wards, analyzed whether their placement times were reasonable, assessed the reasons for unreasonable placement times, and took intervention measures. Similarly, the storage time of finished infusion was deemed reasonable or unreasonable, the reasons for unreasonable storage times were analyzed, and intervention measures were taken.

Results

In September 2021, the proportion of infusions stored for an unreasonable time was 12.69%, a decrease of 5.37% compared with August 2021, indicating the effectiveness of intervention measures.

Conclusion

By using statistical analysis and intervention measures, our PIVAS improved the standardized use of finished infusion products and ensured the safety of medication for patients.
HLA class II polymorphisms as prognostic biomarkers for right and left-sided colon cancer
Authors: Attia Amani , Lagha Awatef , Mezlini Amel , Ghazouani Ezzedine , Yacoubi-Loueslati Besma , Namouchi Imene
Published: January 2024

Background

Colon cancer (CC) is one of the most common malignancies worldwide. Characterization of new prognostic biomarkers for right-sided CC (RCC) and left-sided CC (LCC) may contribute to improving early detection. An association of human leukocyte antigens class II (HLA-II) with the predisposition to CC was suggested.

Aim of the study

We evaluated the association of DRB1 and DQB1 with the risk of LCC and RCC.

Patients and methods

Our study comprised 93 CC patients and 100 healthy controls. Genotyping of HLA class II alleles were performed by the Polymerase Chain Reaction Sequence-Specific Primers (PCR-SSP).

Results

DRB1*03 was positively associated with CC. In contrast, DRB1*11, DRB1*13, DQB1*03, and DQB1*05 were negatively linked to CC. Haplotype analysis revealed that DRB1*04-DQB1*04 and DRB1*09-DQB1*02 were positive, while DRB1*01-DQB1*05, DRB1*04-DQB1*03, DRB1*07-DQB1*02, DRB1*11-DQB1*03, DRB1*11-DQB1*05, and DRB1*13-DQB1*06 were negatively associated with CC. For sigmoid CC, DRB1*13, DRB1*11, and DQB1*05 were negative, while DRB1*04-DQB1*02, and DRB1*07-DQB1*03 were positively associated. DRB1*03 and DRB1*04-DQB1*04 were positive, while DRB1*11 and DQB1*03 were negatively linked to RCC. According to the LCC, DRB1*07, DRB1*11, DQB1*03, DQB1*05, and DRB1*07-DQB1*02 were negative. In contrast, DRB1*09-DQB1*02 was positively associated with LCC. Stratified analysis revealed that DRB1*11 is associated with higher risk of metastasis in CC and sigmoid CC, and tolerance to treatment in RCC. DQB1*03 was associated with lymph-node invasion in CC.

Conclusion

DRB1 and DQB1 polymorphisms could be used as future biomarkers for the early detection of subjects at a higher risk of developing RCC and LCC, metastasis in sigmoid CC, and tolerance to treatment in RCC.
Statistical modelling of depth milling in Ti-6AL4V using abrasive water jet machining
Authors: Mogul Yakub I , Quadros Jaimon D , Khan Sher Afghan , Agrawal Manoj , Kumar Indradeep , Shaik Saboor , Saleel Chanduveetil Ahamed , Saxena Ashish
Published: January 2024

Multi-objective grey relational analysis optimization technique and multiple regression analysis were employed to determine the optimum values for depth of cut, surface roughness ( Ra), and kerf at entry and exit ([Formula: see text] and [Formula: see text]), for abrasive waterjet machining of Ti6AL4V materials. This method highlights a new process to extend the grey relational analysis technique for determining the optimum conditions for obtaining the best quality characteristics. The input parameters of the study were water pressure ( Wp), transverse speed ( Ts), abrasive mass flow rate ( Amf), abrasive orifice size ( Aos), nozzle/orifice diameter ratio ( N/Odia). The experiments were conducted as per the Taguchi-based L27 orthogonal array. The grey relational analysis technique found that Ts was the most significant parameter on the combined outputs. The regression models developed had an R2 of 81.58%, 79.79%%, 77.20%, and 74.39% for depth of cut, Ra, [Formula: see text] and [Formula: see text], respectively. Additionally, the analysis of variance showed that Wp and Aos had a significant influence on the output parameters. The predicted values were found to be reasonably close with the experimental values, and the maximum average deviation was 8.15% for [Formula: see text].
Who controls the curriculum? Notes on disciplinary communities from Ivor Goodson
Authors: Petrucci-Rosa Maria Inês , OIiveira Paola Fernanda Guidi
Published: January 2024

The present study investigates the devaluation of specialised teaching knowledge and the prioritisation of general education based on competencies and skills at the secondary level in Brazil. The dissolution of the curricular disciplinary organisation poses a risk to teaching identities, and understanding how teachers constitute epistemic and disciplinary communities is crucial. Public imposed policies that are distant from the reality of schools tend to be rejected by the agents involved in the school process. In Brazil, the National Curriculum Basis, a high school common core, is an example of a legal document that does not engage in dialogue with the cultural diversity in Brazil, while discredit the specific formation of teachers. From a historical approach, this research analyses the polysemy of school subjects towards the teacher’s specialised identities. The methodological dispositive comprises narratives from specialist high school teachers in Biology, Physics, and Chemistry. Understanding how professionals organise themselves provides insight into the mechanisms of control and mediation in producing curriculum as socio-historical artifacts from power relationships and disputes. The struggle for control highlights the importance of teachers' agency in confrontation with neoliberal ideals for education and organising in subject or epistemic communities.
Revision of residual deformities after primary surgery for Wassel-Flatt IV-D thumb duplication using a microsurgical free lateral great toe flap
Authors: Yu Wentao , Yin Chunhua , Liu Wei , Wei Song , Yang Guang , Shen Xiaofang
Published: January 2024

We report the application and results of skin defect coverage using the free lateral great toe flap in revision surgery for residual postoperative deformities in Wassel-Flatt type IV-D thumb duplications. This retrospective study included five patients treated between June 2020 and September 2021 to correct angular deformity and repair the secondary skin defect. All the flaps survived. The patients were followed up for 8–12 months and all the reconstructed thumbs had a satisfactory appearance. The results of the Japanese Society for Surgery of the Hand scoring system were excellent in one patient, good in three patients and fair in one patient. The results of the Alignment, Ulnar and Radial stability, Range of motion and Aesthetical aspects (ALURRA) scoring system were good in four patients and moderate in one patient.

Level of evidence: IV