bluuebunny/crossref_metadata_2025 huggingface dataset:
intelectuais em Gramsci
Authors: Valéria Delage Vicente Mancini Marina , Santos Greice dos Reis
Published: June 2021

O presente artigo aborda a contribuição de Antonio Gramsci – e do marxismo – acerca do conceito e da função dos intelectuais. A partir disso, busca saber se o/a assistente social, enquanto profissional que trabalha com a classe expropriada de seus direitos fundamentais, pode assumir ou não a função de intelectual orgânico. Todo o processo de investigação gira em torno dessa questão que, ao nosso modo de ver, precisa ser aprofundada.
NONLINEAR TRANSVERSE VIBRATIONS OF COMPOSITE RODS UNDER THE ACTION OF A STATICALLY APPLIED TRANSVERSE LOAD
Authors: Balamirzoev A. , Murtuzov M. , Selimhanov D. , Dibirova Z. , Abdullaev A.
Published: June 2021

Nonlinear transverse vibrations of composite rods pre-loaded with lagging arranged symmetrically on both sides of the axis of the composite rod under the action of a statically applied transverse load are investigat-ed. The cases of attaching the lagging only to the ends of the composite rod, as well as when the laggings are continuously attached to the composite rod along its entire length, are considered. The results of the study of nonlinear transverse vibrations of composite rods under the action of a statically applied transverse load are presented. When conducting studies of transverse vibrations of composite rods, solutions of differential equations of vibration of prestressed through beams and stiffening cores of high-rise buildings are obtained. The obtained differential equations of vibration of composite rods allow us to determine the dynamic char-acteristics of prestressed through beams under various linear and boundary conditions. A method for com-posing differential equations of free and forced oscillations of prestressed through beams and stiffening cores of high-rise buildings and solving differential equations under various linear and nonlinear boundary conditions is developed.

Expressions are given for determining the longitudinal forces and torques at the ends of the rod at any lo-cation of the lagging from the axis and at any different stiffness of the lagging
FISH investigation of the bacterial groups anammox and Azoarcus-Thauera at treatment of landfill leachate
Authors: Belouhova M. , Dinova N. , Yotinov I. , Lincheva S. , Schneider I. , Topalova Y.
Published: June 2021

The landfill leachate is heavily polluted wastewater produced in the landfills. The management of the purification of the leachate is especially challenging and that is why new approaches and indicators are needed. The quantity, localization, interaction, clustering of the key microbial groups, responsible for the critical transformation processes can be used as indication leading to better performance of the technology. This study is focused on two bacterial groups (Anammox and Azoarcus-Thauera cluster) which have potential to serve as indicators for the landfill leachate treatment. Their quantity and activity were studied by FISH during lab-scale treatment of leachate from the Municipal Enterprise for Waste Treatment (MEWT), Sofia, Bulgaria. Two activated sludges (AS) were used – one from the MEWT and another form the WWTP (wastewater treatment plant) of Sofia. The obtained results showed that 74% of the COD was eliminated when leachate was diluted 50 and 25 times and 31% - when undiluted leachate was used. At the end of the process (21 day) the Azoarcus-Thauera group formed large aggregations in the AS from MEWT. They were 17.50% of the bacteria there while in the AS from the WWTP of Sofia they represented only 2.61%. The quantity
of the anammox bacteria remained almost unchanged during the process and was 10.75% of the community from MEWT which eliminated 98 mg/L more ammonium ions at the end of the process and 6% from the community from the WWTP of Sofia. The two studied groups gave more complex information about the processes in the AS related to
the elimination of the nitrogen and carbon containing pollutants. They could be used for better management of the biological processes during landfill leachate treatment.

Key words: landfill leachate; anammox, Azoarcus-Thauera; activated sludge; fluorescence in-situ hybridization
Фізико-хімічні дослідження впливу добавок на біоводостійкість конструкцій
Authors: Драпалюк М.В.
Published: June 2021

У статті доведено, що біопошкодження бетону каналізаційних колекторів пов'язане з діяльністю мікроорганізмів (бактерій). З’ясовано, що біостійкість бетону може бути забезпечена двома способами: запобіганням поверхневого тріщиноутворення; створенням «біоімунітету» бетону до життєдіяльності мікроорганізмів. У статті представлені результати дослідження пористості модифікованої цементної матриці. Встановлено, що в новоутвореннях модифікованої цементної матриці бетону зміст вільного гідроксиду кальцію не перевищує 5%, що є необхідною умовою для отримання матеріалу, стійкого до корозії.
The Effects of 6-Week Supplementation with Multicomponent Herbal Extract on Exercise Performance, Antioxidant Status and Telomere Length, and Self-Reported Side Effects in Healthy Men: A Randomized Controlled Pilot Trial
Authors: Stajer Valdemar , Todorovic Nikola , Korovljev Darinka , Maksimovic Nebojsa , Miljkovic Suzana , Ratgeber Laszlo , Betlehem Jozsef , Acs Pongras , Ostojic Sergej M.
Published: June 2021

The main aim of this study was to examine the effects of medium-term supplementation with an eight-herbs extract on running performance, biomarkers of antioxidant status and telomere length, and self-reported outcome measures of safety events in healthy men. Ten healthy young men (age 23.1±3.2 years, weight 73.7±9.9kg, and height 179.4±8.0cm) volunteered to participate in this randomized controlled trial. The participants were allocated in a double-blind cross-over design to receive either an eight-herbs extract or placebo during a 6-week intervention period. Two-way mixed analysis of variance (treatment vs. time interaction) revealed no significant differences for exercise performance outcomes and telomere length between groups (P>0.05). Compared with placebo, P-DNA provoked a significant rise in serum total antioxidant capacity (316.0±183.4µmol/mL at baseline; 792.7±68.1µmol/mL at follow-up in the eight-herbs extract group vs. 298.1±90.7µmol/mL at follow-up in the placebo group; P<0.001), and less reduction in serum superoxide dismutase levels at follow-up (150.4±5.1IU/mL at baseline; 145.5±3.0IU/mL at follow-up in the eight-herbs extract group vs. 139.3±3.3IU/mL at follow-up in the placebo group; P=0.01). No participant reported any side effects of either intervention. The eight-herbs extract can thus be recommended as a well tolerated dietary supplement that can enhance antioxidant capacity in healthy men. This trial was registered at ClinicalTrials.gov (NCT04263246).
Cholesterol in autism spectrum disorders
Authors: Franco Rafael , Rivas-Santisteban Rafael , Navarro Gemma , Reyes-Resina Irene
Published: June 2021

The autism spectrum disorder (ASD) comprises a series of neurological diseases that share serious alterations of the development of the central nervous system. The degree of disability may vary so that Asperger’s may have a relatively normal life and get positions of responsibility in corporations and even in Governments, whereas other ASD sufferers are fully dependent on caregivers and have serious cognitive deficits. Although the first cases of autism were detected by looking at failures in metabolism, e.g., phenylketonuria, to later identify the faulty gene, today the trend is the opposite, first obtaining the exome and minimizing the look for altered parameters in blood, urine, etc. Cholesterol is key for neural development as it is not able to cross the blood brain barrier. Therefore, any gene or environmental factor that affects cholesterol synthesis will impact early developmental stages eventually leading to a disease within the autism spectrum and/or schizophrenia. This review provides data of the relevance of cholesterol dyshomeostasis in autism spectrum disorders. Determining biochemical parameters in body fluids should help to provide new therapeutic approaches in some cases of autism.
A Cross-Sectional Study on Psychosocial Impact of Covid19 among Suspects
Authors: Dattatraya Dinna Bant  , Bushra Jabeen  , Sushma HR  , A Akshay Subramanian
Published: June 2021

Background: COVID pandemic in India,like all the other affected countries,with its uncertainites affected the psychosocial impact of masses including the suspects . When the global focus has mostly been on testing, finding a cure and preventing transmission, people went through a myriad of psychosocial problems in adjusting to the current lifestyles and fear of the disease. However, only few studies have been conducted regarding the mental health of people amidst the pandemic. This study mainly explores the psychosocial impact of COVID19 among people including the suspects. Methods: A cross sectional study was done over a period of 1 month to assess the psychosocial impact of Covid among suspects.The data was collected using predesigned, semi-structured questionnaire. It was circulated among general public, especially those residing in containment ares and those who are at high risk. The data compilation was done using Ms Excel and analysis was done using SPSS Statistics. Results: There were a total of 230 responses from different parts of the country. The mean age of the respondents was around 21-30 years. Out of these, 25 respondents were suspects of COVID-19. A higher level (80%) of psychosocial distress was found among suspects. Conclusion: The mental problems caused by COVID-19 lockdown not only impacted the psychosocial wellbeing of suspects but also individuals from the entire community including students, casual labourers, healthcare professionals and the general population. The study also showed that there was a higher level of fear and anxiety among the suspects when compared to the general public . In addition, constant mental pressure also eventually led to difficulty in sleeping among suspects.
Outcome of SARS-CoV-2 in pregnancy and newborns – is there a new kid in the TORCH block?
Authors:   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Nita Andreia Florina , Manolescu Sabina Cornelia ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Popa Mircea Ioan ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   “Cantacuzino“ National Medico-Military Institute for Research and Development, Bucharest, Romania, Popa Loredana Gabriela ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Colentina Clinical Hospital, Bucharest, Romania
Published: June 2021

Objective. This study aimed to perform a systematic review of existing literature to assess the outcomes of pregnancy in women with COVID-19 infection and their newborns while estimating the possibility of vertical transmission. Materials and methods. We conducted a systematic literature research using Pubmed and Google Scholar covering the period from December 2019 to 20th of November 2020. The review was conducted in accordance with PRISMA guidelines. Outcomes. We included 16 studies – systematic reviews and meta-analyses published between May 2020 and November 2020 – which focused on perinatal outcomes of pregnant women with COVID-19 and 7 case reports of neonates with congenital transmission of COVID-19. Overall, the rate of COVID-19 cases in neonates of COVID-19 positive mothers was 3% with 95% CI [1.86, 4.24]). The preterm birth rate was 16.4% with 95% CI [10.5, 22.3] and the rate of stillbirths and foetal deaths was 1.4% (11 studies, 0 to 4.8%). From the 7 newborns with proved vertical transmission, majority were born preterm, with good birth weight and APGAR score and heterogenous symptoms; 4 developed severe symptoms. Overall progress and evolution for both mother and newborn was good. Conclusions. COVID-19 impact on pregnancy outcome is similar to general population in regard to preterm rate and stillbirth rate. Vertical transmission is possible and it seems to occur in about 3% of cases. Overall maternal and perinatal outcome is favourable and clinical presentation of in utero transmission of SARSCoV-2 in newborns is heterogenous.
Management of SARS-CoV-2 infection in pregnancy
Authors:   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Stanica Cătălina Diana , Sima Romina Marina ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Ioan Raluca Gabriela ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Nanu Constantin Dimitrie ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Neacsu Adrian ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: June 2021

The SARS-CoV-2 infection, which originated from a market in Wuhan, China, spread rapidly, so on March 11, 2020, the WHO decreed that the outbreak became a pandemic. Over 90% of people infected with SARS-CoV-2 are either asymptomatic or have mild symptoms. However, there are cases that develop severe forms of the disease, from acute respiratory distress syndrome to septic shock with multiorgan failure and exitus. However, reports of pregnant women diagnosed with Covid-19 are low. Changes in the maternal organism in pregnancy, including immunity, respiratory system and hypercoagulability, but also various comorbidities, could be a risk factor for pregnant women to develop complications associated with COVID-19, with increased morbidity and mortality compared to the general population. The effects of SARS-CoV-2 infection on pregnancy are not sufficiently understood, nor are the effects of pregnancy on disease progression. Although the existence of the virus has been shown in biological samples such as the placenta, umbilical cord, or amniotic fluid, the maternal and fetal effects of the virus are not well known. Recent studies confirm the possibility of intrauterine maternal-fetal transmission of the virus, but also of specific antibodies. The possibility of infection by breastfeeding is not yet sufficiently investigated. We looked for data on the treatment and prophylaxis of SARS-CoV-2 infection during pregnancy, as well as on the choice of the optimal birth pathway in these women. The aim of this paper was to conduct a systematic review of the literature on pregnancy and birth management in patients infected with SARS-CoV-2 that could lead to an improvement in the quality of their medical care.
Methods for screening and prevention of HPV infection – a retrospective study
Authors:   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Stanica Catalina Diana , Sima Romina Marina ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Ioan Raluca Gabriela ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Nanu Constantin Dimitrie ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Neacsu Ilinca ,   Department of Pathology, “Binafarm”, Bucharest, Romania,   Translational School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom, Neacsu Adrian ,   Department of Obstetrics and Gynecology, ”Carol Davila” University of Medicine and Pharmacy, Bucharest
Published: June 2021

Worldwide, cervical cancer ranks 4th in frequency in the female population, with about half of the cases being fatal. In Romania, it is the second type of cancer found in women, after breast cancer and the main cause of cancer mortality in patients aged between 15 and 44 years. The main cause of this type of cancer is human papilloma virus (HPV) infection. Although HPV is very widespread (> 85%), progression to cervical cancer is relatively rare. In countries that have implemented cervical screening programs, the incidence and mortality caused by this pathology have decreased by 50-75%. Also, the emergence of vaccines against the most common strains of oncogenic HPV and the implementation of vaccination programs will bring additional benefits in preventing cervical cancer. This paper presents the results of a retrospective study, performed on a number of 92 patients, which aimed to know the distribution of different HPV genotypes, their impact on the cervical epithelium, the degree of access to the national screening program, and openness to anti HPV vaccination.
The safety of new oral anticoagulants for ischemic stroke and systemic embolism prevention in females with atrial fibrillation
Authors:   EuroEchoLab, Craiova, Romania, Toader Despina-Manuela ,   Cardiology Center, Emergency Hospital, Craiova, Romania, Neaca Ileana ,   Sanocare Clinic, Craiova, Romania, Paraschiv Alina ,   Cardiology Center, Emergency Hospital, Craiova, Romania, Musetescu Rodica ,   Faculty of Medicine, University of Medicine and Pharmacy, Craiova, Romania
Published: June 2021

The prevalence of atrial fibrillation is lower in females than in men, but the risk of stroke and systemic thromboembolism is comparable or even higher. Administration of anticoagulant therapy does not modify this difference. Two classes of non-vitamin K antagonist oral anticoagulants were studied in atrial fibrillation: direct thrombin inhibitors, like Dabigatran, and activated factor X inhibitors, like Rivaroxaban, Apixaban and Edoxaban. Response to oral anticoagulants could differ between the gender. This medication was evaluated in phase III randomized controlled trials. Non-vitamin K antagonist oral anticoagulants have been proved more efficacious than Warfarin for stroke and systemic embolism prevention in women, but conclusions regarding the safety and the bleeding are heterogeneous. As in men, before prescribing a NOAC to a female with AF, the stroke and the bleeding risk have to be carefully estimated. It is important that future studies to be targeted on comparison between of non-vitamin K antagonist oral anticoagulants versus Warfarin in females with non-valvular atrial fibrillation.
Single cervical spinal extramedullary tuberculous lesion in a young female – case report
Authors:   Neurosurgery I Clinic, Emergency University Hospital, Bucharest, Romania, Bibirita Alexandra , Nicolae Alexandru ,   Neurosurgery I Clinic, Emergency University Hospital, Bucharest, Romania, Dumitru Adrian ,   Department of Pathology, Emergency University Hospital, Bucharest, Romania, Teleanu Daniel Mihai ,   Neurosurgery I Clinic, Emergency University Hospital, Bucharest, Romania,   Department of Neurosurgery, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania
Published: June 2021

Skeletal tuberculosis is the main extrapulmonary site for Mycobacterium tuberculosis infection disemination. As for the nervous sistem tuberculosis or spinal tuberculous disease in particular, the osseos elements are more frequently involved than the cerebral tissue or the spinal cord. We present the case of a previously healthy 32 year old female with no known TB history, reffered to our clinic for neck pain thought to be due to degenerative spinal disc disease. In the absence of general signs of the disease, the right surgical management and biopsy were the key factors for corect diagnosis.
The prevalence and associated factors of aspirin resistance among prophylactic aspirin users
Authors:   Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Ghorbani-Shirkouhi Samaneh , Ashouri Fatemeh ,   Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Neshin Saeideh Aghayari Sheikh ,   Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Saberi Alia ,   Neuroscience Research Center, Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Hasanzadeh Bahador ,   Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Shahshahani Parisa ,   Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Published: June 2021

Background. Aspirin is an antiplatelet used for the secondary prevention after vascular events. It is also suggested for the primary prevention of vascular events in high risk people, however, despite using standard prophylactic doses, aspirin resistance may result in therapeutic failure and arterial thrombosis. Since the prevalence of aspirin resistance and its associated factors were heterogeneous in different studies, this study was conducted to determine the prevalence and associated factors of aspirin resistance in an Iranian population under aspirin for primary prevention of vascular events. Methods. 264 patients without documented vascular disease with 80 mg daily aspirin consumption for at least one month enrolled in this cross-sectional study. Aspirin resistance was assessed by the measurement of thromboxane B2 in the urine samples using the enzyme-linked immunosorbent assay method. Aspirin resistance was defined as a urine level of thromboxane B2 ≥ 1700 ng/dl. Results. The prevalence of aspirin resistance in this study was 9.8%. Age (OR = 0.935, 95% CI: 0.880-0.993, P = 0.028) and geographical regions (OR = 0.117, 95% CI: 0.014-0.958, P = 0.045) showed independent correlation with aspirin resistance. No significant association observed between aspirin resistance and gender, diabetes mellitus, hypertension, hyperlipidemia, smoking, duration of aspirin use, body mass index, and drug history. Conclusions. Despite the standard daily dose of aspirin for primary prevention of vascular events, some of our patients exhibited aspirin resistance that was directly related to a higher age and geographical region. More studies are required to clarify the beneficial role of aspirin resistance test before planning a preventive strategy in high risk individuals.
Terapii inovative în bolile genetice: Fibroza chistică
Authors:   Centrul Național Clinic de Recuperare Neuropsihomotorie pentru Copii „Dr. Nicolae Robănescu“, București, România, Shelby Elena-Silvia , Nedelea Florina Mihaela ,   Departamentul de Genetică Medicală, Spitalul Clinic de Obstetrică și Ginecologie, „Filantropia“, București, România,   Catedra de Genetică, Universitatea de Medicină și Farmacie „Carol Davila“, București, România, Huseyinoglu Tanser ,   Departamentul de Genetică Medicală, Spitalul Clinic de Obstetrică și Ginecologie, „Filantropia“, București, România, Cocoș Relu ,   Catedra de Genetică, Universitatea de Medicină și Farmacie „Carol Davila“, București, România, Bădina Mihaela ,   Centrul Național Clinic de Recuperare Neuropsihomotorie pentru Copii „Dr. Nicolae Robănescu“, București, România, Sporea Corina ,   Centrul Național Clinic de Recuperare Neuropsihomotorie pentru Copii „Dr. Nicolae Robănescu“, București, România, Pădure Liliana ,   Centrul Național Clinic de Recuperare Neuropsihomotorie pentru Copii „Dr. Nicolae Robănescu“, București, România,   Facultatea de Moașe și Asistență Medicală, Universitatea de Medicină și Farmacie „Carol Davila“, București, România, Mirea Andrada ,   Centrul Național Clinic de Recuperare Neuropsihomotorie pentru Copii „Dr. Nicolae Robănescu“, București, România,   Facultatea de Moașe și Asistență Medicală, Universitatea de Medicină și Farmacie „Carol Davila“, București, România
Published: June 2021

Fibroza chistică, numită și mucoviscidoză, este cea mai frecventă boală pulmonară ereditară și este produsă de mutații în gena CFTR, ce codifică un canal anionic pentru clor și bicarbonat cu rol în reglarea metabolismului bicarbonatului și sării. În momentul de față, aproximativ jumătate din totalul pacienților cu fibroză chistică pot beneficia de terapie personalizată cu ajutorul modulatorilor, substanțe care restaurează sau îmbunătățesc funcționalitatea și stabilitatea CFTR. Mai mult, la ora actuală se află în stadiul de studiu clinic și alte tipuri de terapii, ca de exemplu terapia genică utilizând sistemul CRISP/CAS-9, oligonucleotide antisens modificate sau inserția genei sălbatice utilizând particule nanolipidice sau vectori virali. Acest articol își propune să treacă în revistă principalele tipuri de terapii aprobate sau aflate în stadiul de studiu clinic pentru tratamentul fibrozei chistice.
Insuficiența cardiacă pediatrică
Authors:   Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade“, Tg. Mureş, România, Muntean Iolanda ,   Clinica Cardiologie III, Institutul de Urgență pentru Boli Cardiovasculare și Transplant, Tg. Mureş, România, Barmou Asmaa Carla ,   Clinica Cardiologie III, Institutul de Urgență pentru Boli Cardiovasculare și Transplant, Tg. Mureş, România, Gozar Liliana ,   Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade“, Tg. Mureş, România, Făgărășan Amalia ,   Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade“, Tg. Mureş, România
Published: June 2021

Insuficiența cardiacă pediatrică reprezintă o provocare în practica clinică și o povară la nivel mondial. În comparație cu populația adultă, etiologia insuficienței cardiace la copii este dependentă de vârsta pacienților. Cu toate acestea, ghidurile referitoare la insuficiența cardiacă pediatrică sunt extrapolate din ghidurile pentru adulți. În cazul sugarilor și al copiilor, tratamentul farmacologic este bazat pe inhibitori de enzimă de conversie, betablocante, antagoniști ai receptorilor de aldosteron și alte diuretice (în prezența congestiei). În insuficiența cardiacă terminală, dispozitivele de asistare ventriculară sau diferite intervenții chirurgicale paliative sunt utilizate ca o punte pentru transplant sau recuperare. Prezenta lucrare se concentrează pe cele mai importante cauze, mecanisme fiziopatologice, manifestări clinice și managementul în insuficiența cardiacă pediatrică, bazate pe cele mai recente ghiduri. În plus, subliniază cele mai noi tratamente farmacologice și nonfarmacologice recent aprobate pentru populația pediatrică.
Radiographic assessment in rheumatoid arthritis: From daily practice to clinical trials
Authors:   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania, Mogosan Corina ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Enache Luminita ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Dumitrescu Bianca ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania, Agache Mihaela ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Catalina ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Popescu Claudiu ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Codreanu Catalin ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania
Published: June 2021

Imaging evaluation in rheumatoid arthritis (RA) has evolved significantly in last decades. Even if the modern imaging technics like ultrasound and magnetic resonance imaging have unequivocal place in the assessment of early disease (especially for synovial inflammation, bone oedema, erosions), radiographic evaluation of hands and feet is still the most widely used imaging technic for quantification of joint damage in RA. In the current review we aim to address some practical issues related to the radiographic evaluation in RA from daily practice perspective, followed by a broader approach from the clinical trials point of view.
Antiphospholipid syndrome and cancer
Authors:   5th Department, Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Razvan Adrian ,   3rd Clinic, Internal Medicine, Colentina Clinical Hospital, Bucharest, Romania
Published: June 2021

Antiphospholipid antibodies syndrome (APS) is an acquired prothrombotic status, that is due to the occurrence of a certain type of autoantibodies directed against negatively charged phospholipid structures – hence the name. Neoplasia is also characterized by a systemic procoagulant status, through various mechanisms. Obviously, both conditions may occur in the same patient, raising the question of a possible causal relation. Regardless of the potential liaison between the two events, clinicians caring for neoplastic patients as well as for APS patients, should be aware of the presence of both conditions in the same patient, as this has important therapeutic consequences.
Two case reports and a literature review on eosinophilic fasciitis
Authors:   “Carol Davila” University and Pharmacy, Bucharest, Romania, Mazilu Diana ,   “Sf. Maria” Clinical Hospital, Bucharest, Romania, Saulescu Ioana ,   “Carol Davila” University and Pharmacy, Bucharest, Romania,   “Sf. Maria” Clinical Hospital, Bucharest, Romania, Ionescu Ruxandra ,   “Carol Davila” University and Pharmacy, Bucharest, Romania,   “Sf. Maria” Clinical Hospital, Bucharest, Romania
Published: June 2021

Eosinophilic fasciitis is a rare disorder of unknown etiology and poorly understood pathogenesis. It may be triggered by excessive exercise, physical factors such as radiation therapy, exposure to certain medications, infections, the initiation of hemodialysis and some other medical conditions. Skin modifications appear with collagenous thickening of the subcutaneous fascia with typical aspect of “peau d’orange” and the “groove sign”. Arthritis, myalgia, myositis, neuropathies may occur. The majority of patients have peripheral blood eosinophilia. The diagnosis is confirmed with a full thickness incisional biopsy of skin and subcutaneous tissue down to the muscle surface and fascia. Systemic glucocorticoids are the mainstay of treatment, but some patients require additional immunosuppressive therapy. The long-term prognosis of this disease is unknown and in some cases the disease may releapse. We describe two patients with eosinophilic fasciitis, their evolution and complications, associating other pathologies: morphea and antiphospholipid syndrome, making the diagnosis and the treatment more challenging.
Therapy with bone-modifying agents in cancer patients: Efficacy versus adverse events in dental medicine
Authors:   Orthodontics Department, “Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania, Bunta Olimpia , Crintea Iulia Najette ,   “Victor Babes“ University of Medicine and Pharmacy, Timisoara, Romania,   „Pius Brinzeu” Timis County Emergency Clinical Hospital, Timisoara, Romania, Pop Andreea ,   Oral Rehabilitation Department, “Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania, Nemes Adina ,   Medical Oncology Department, “Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania,   „Prof. Dr. Ion Chiricuta” Oncology Institute, Cluj-Napoca, Romania, Pacurar Mariana ,   Orthodontics Department, “G.E. Palade“ University of Medicine and Pharmacy Science and Technology, Tg. Mures, Romania
Published: June 2021

Bone metastases affect a large number of oncological patients and can determine complications that can impact the quality of life of our patients and further translate into lessen treatment results and overall survival. Treatment with bisphosphonates (BP) has proven its efficacy in preventing the development of the complications related to bone metastases. BP are well tolerated in general but severe adverse events can occur, like osteonecrosis of the jaw (ONJ). Besides ONJ there are other dental and maxillofacial complications determined by BP, complications that by elementary preventive measures can be avoided.
Study on the relationship between menopausal age, body mass index and total number of teeth
Authors:   Doctoral School, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Lescai Ioana Madalina ,   Blident Help Dental Clinic, Bucharest, Romania, Mihai Laurenta Lelia ,   Department of Periodontology and Oral Pathology, “Titu Maiorescu“ University, Bucharest, Romania, Cirstoiu Monica Mihaela ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics & Gynaecology, University Emergency Hospital, Bucharest, Romania
Published: June 2021

Objectives. The objective of this study is to assess the state of oral health, from the perspective of the number of teeth present, according to the body mass index as a representative element of health. Materials and methods. This study consists of 180 patients from a private dental practice. All 180 patient records were reviewed for an assessment of the number of teeth present and the body mass index at menopausal age. The cohort of patients was divided into two groups, a group of women aged 40 to 54.9 years and the second group, which included women aged 55 and over. The 2 groups were divided based on premenopausal (group I) and postmenopausal (group II) age. Results. The average number of present teeth (based on radiographs) for the entire population of 180 patients is 22.02 teeth. In group I, for the 109 women in the premenopausal group, the average number of teeth is 23.94. The total number of teeth for the 71 women in the postmenopausal group is 19.07. The average BMI for the entire group of patients is 27.24 kg/m2, with a lower value in group I, 26.25 kg/m2, compared to group II, 28.78 kg/m2. Discussions. The average number of teeth in the premenopausal group is higher than in the postmenopausal group. The average body mass index places the whole series of patients in the overweight category. Conclusions. This study shows that the relationship between BMI and the number of lost teeth is positive and proportional, BMI increases with increasing number of teeth lost at premenopausal age.
Considerations regarding the osseointegration of endosseous dental implants
Authors:   Catedra de Tehnologia Protezelor şi Materiale Dentare, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România, Pătrașcu Ion , Gălbinașu Bogdan Mihai ,   Catedra de Tehnologia Protezelor şi Materiale Dentare, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România
Published: June 2021

Implant osseointegration has not been accepted over time, considering that in fact the implant integration is performed only in the soft tissue of the host. For this reason, the implant has never been sufficiently integrated into the host tissue immediately after insertion. Experiments performed in Branemark laboratories in the early 1960s, with a new type of implant, which required a direct anchorage to bone tissue for clinical function, this anchorage was called osseointegration. It has been shown that it is possible to achieve direct osseointegration if the Branemark method is considered, which was published a few years later in the first clinical report. The authors of this article come up with new contributions that validate the implant osseointegration process. Inside this article we present our methodology for evaluating the osseointegration of endosseous implants: ESEM (environmental scanning electron microscope) studies of the implant-bone tissue interface.
Romanian dentists’ perception of flexible removable partial dentures
Authors:   Periodontology, „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Dragomir Georgiana , Farcasiu Alexandru Titus ,   Removable Prosthodontics Departament, „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Pascal Iulia ,   Removable Prosthodontics Departament, „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: June 2021

Introduction. A flexible partial denture, as a treatment solution for partial edentulousness, is a current alternative in dental prosthetics, due to simplified design, aesthetic and biomechanical qualities of resin materials, that contribute to the favourable distribution of masticatory forces on the dental and mucosal support. Objective. This study aims to highlight the medical perception of Romanian dentists regarding the evolution of patients treated with flexible partial dentures. Material and method. The research was carried out over a period of two years (2017-2019), on a study group composed of 84 Romanian dentists. Subjects were asked to answer an anonymous questionnaire consisting of 14 closed questions, to outline frequently aspects encountered in practice related to the clinical evolution of the patient rehabilitated with flexible partial removable dentures. Outcomes. Patient comfort (76%) and higher aesthetic properties (54%) were the main reasons why dentists chose a partially flexible prosthetic for the prosthetic treatment of the patient. In the evolution of prosthetic patient, the main problems found at the partial flexible prosthesis were food pigment impregnation of the base (51%) and limited possibilities of repair (34%). Changes in maintenance, support, stability, aesthetic or possible fractures of base and clasps were seen by 46% of respondents, at approximately 1 to 2 years after the application of flexible partial dentures. Conclusions. Flexible partial prosthesis is a method of treatment, whose main advantages are represented by esthetics and superior adaptation of the patients, but because of the deficiencies that occur over time, it is better to be recommended as a provisional treatment solution.
'Part of the Future'
Authors: Bell Felicity
Published: June 2021

In March 2020, the family law courts, like other Australian courts, moved to hearing proceedings ‘remotely’, by phone, audio-visual link or software platform. This article examines the particular circumstances of family law cases that likely impact on whether it is appropriate for remote procedures to be used. Giving context to these themes, the article reports on a survey of Australian federal judicial officers about their experiences of conducting family law proceedings remotely.
Metastable Helium Absorptions with 3D Hydrodynamics and Self-consistent Photochemistry. II. WASP-107b, Stellar Wind, Radiation Pressure, and Shear Instability
Authors: Wang Lile , Dai Fei
Published: June 2021

This paper presents simulations of the metastable helium (He*) observations of WASP-107b, so far the highest signal-to-noise ratio detection that is confirmed by three different instruments. We employ full 3D hydrodynamics coupled with coevolving nonequilibrium thermochemistry and ray-tracing radiation, predicting mass-loss rates, temperature profiles, and synthetic He* line profiles and light curves from first principles. We find that a stellar wind stronger than solar is demanded by the observed heavily blueshifted line profile and asymmetric transit light curve. Radiation pressure can be important for Lyα observations, but not He*. Our model finds that WASP-107b is losing mass at a rate of

M

̇

≃
1.0
×

10

−
9

M

⊕

yr

−
1

. Although

M

̇

varies by <1% given constant wind and irradiation from the host, shear instabilities still emerge from wind impacts, producing ∼10% fluctuations of He* transit depths over hour-long timescales. The common assumption that He* transit depth indicates the fluctuation of

M

̇

is problematic. The trailing tail is more susceptible than planet adjacency to the shear instabilities; thus, the line profile is more variable in the blueshifted wing, while the transit light curve is more variable after midtransit. We stress that the synergy between Lyα (higher altitudes, lower density) and He* (lower altitudes, higher density) transit observations, particularly simultaneous ones, yields better understanding of planetary outflows and stellar wind properties.
Two new species of the Balkan genus Paladilhiopsis Pavlović, 1913 (Caenogastropoda, Moitessieriidae)
Authors: Hofman Sebastian , Grego Jozef , Rysiewska Aleksandra , Osikowski Artur , Falniowski Andrzej
Published: June 2021

The Balkan Peninsula is inhabited by the worldwide most diverse subterranean gastropod fauna. This fauna is still poorly studied, since its habitats are not easily accessible, and its sampled populations are mostly not rich in specimens’ numbers. Often only empty shells are known, but the shell is hardly useful, not only in phylogeny reconstruction, but even in species determination. The exclusively obligatory subterranean family Moitessieriidae is especially poorly studied. Representatives of the genusPaladilhiopsisPavlović, 1913 (Moitessieriidae) collected at three localities, distributed in Croatia and Bosnia & Herzegovina, were studied. The pigmentation of their shells and soft parts, as well as the female and male reproductive organs in one taxon, are presented. The partial sequences of the molecular markers mitochondrial cytochrome oxidase subunit I (COI) and nuclear histone 3 (H3) were used to infer their systematic status and phylogenetic relationships. Two species new to science are described. For one of them, also studied anatomically, 15 specimens were sequenced for COI, and all show the same haplotype.
Du discours des normalisateurs anglo-saxons sur la qualité de l’information comptable
Authors: Colasse Bernard , Michaïlesco Céline
Published: June 2021

Cette étude traite des réponses données par les normalisateurs anglo-saxons, dans leurs cadres conceptuels, à la question des qualités que devrait posséder l’information comptable. Un examen critique de leurs propositions au regard de la théorie économique puis de la théorie de l’information est mené. Celles-ci assimilent indûment l’information financière à un bien et font l’impasse sur le système qui la produit ou sur les acteurs qui gèrent ce système. Eu égard aux faiblesses théoriques des propositions anglo-saxonnes de définition de la qualité de l’information comptable, il est possible de questionner la finalité de ces propositions. Il apparaît que, sous les apparences d’un discours technoscientifique, les normalisateurs tiendraient un discours rhétorique à vocations politiques multiples.
La question du Brexit sous la présidence allemande. D’une négociation à hauts risques vers un Brexit dur
Authors: Trouille Jean-Marc , Trouille Helen
Published: June 2021

Tout au long de la présidence allemande de l’Union, l’un de ses enjeux fondamentaux aura été de mener à leur terme les discussions sur la relation future entre l’Union Européenne et le Royaume-Uni. Michel Barnier, responsable des négociations sur la sortie du Royaume-Uni, a pu compter sur le soutien inconditionnel apporté par cette présidence, afin d’éviter un no deal , qui eut été dommageable à tous, tout en préservant l’unité des 27 États-membres. L’accord, conclu à la veille de Noël 2020 après bien des péripéties, offre un cadre dans lequel s’inscrira la relation future. Mais Michel Barnier invite les Européens à rester vigilants. Comme le démontrent les auteurs, le Royaume-Uni post-Brexit, gagné par une idéologie national-populiste rétrograde ainsi qu’une corruption rampante au plus haut niveau du gouvernement, restera l’enfant terrible d’une Europe que les avocats les plus ardents du Brexit rêvent toujours de détruire.
Un estudio hermenéutico de comparación textual de Job 38,36-37: a partir de la «música de cielos» de fray Luis de León
Authors: Bao Weixin
Published: June 2021

La música de las esferas es una de las concepciones importantes para entender varios escritos –tanto literarios como exegéticos– de fray Luis de León, como su Exposición del Libro de Job. Sin embargo, parece que esta idea tradicional del universo no ha dejado sus huellas en las traducciones bíblicas con las que estamos familiarizados hoy en día. Frente a tal perplejidad hermenéutica, concentrándose en Job 38,36-37, este trabajo pretende realizar un estudio de comparación textual y revisión exegética a partir de la exposición luisiana, a fin de conocer mejor los avatares de estos dos versículos enigmáticos con la ayuda de la «música de cielos».
Contributions et coordination des makers face à la crise du Covid-19
Authors: Viseur Robert , Charleux Amel
Published: June 2021

Le mois de mars 2020 fut marqué pour de nombreux pays européens (Italie, France, Belgique…) par la diffusion exponentielle de la maladie du Covid-19. À la suite du manque d’anticipation des gouvernements et aux tensions sur les approvisionnements en matériels, la mobilisation des makers fut particulièrement remarquée, dans leurs efforts pour fournir en masques les personnels soignants, mais aussi dans leur participation à l’émergence de projets open source plus complexes tels que les respirateurs. Cette recherche exploratoire s’intéresse à la nature des productions proposées par l’action collective des makers, ainsi qu’aux différentes structures de coordination leur permettant de maximiser l’utilité de leurs réalisations et d’en améliorer les propriétés.
Une plateforme en pair-à-pair pour l’échange de données
Authors: Stiefel Léa , Sandoz Alain
Published: June 2021

L’article examine le cas d’une plateforme en pair-à-pair permettant l’échange de données privées entre opérateurs de bases de données. Il soutient que le cas possède sur le plan de sa conception certaines propriétés associées aux communs et démontre en particulier comment une structure de gouvernance s’inscrit dans l’architecture technique. Cette observation plaide en faveur d’une spécificité des communs numériques.
AN AUTOMATED METHOD TO DETECT AGE-RELATED MACULAR DEGENERATION FROM OPTICAL COHERENCE TOMOGRAPHIC IMAGES
Authors: Thomas Anju , Harikrishnan P. M. , Gopi Varun P. , Palanisamy P.
Published: June 2021

Age-related macular degeneration (AMD) is an eye disease that affects the elderly. AMD’s prevalence is increasing as society’s population ages; thus, early detection is critical to prevent vision loss in the elderly. Arrangement of a comprehensive examination of the eye for AMD detection is a challenging task. This paper suggests a new poly scale and dual path (PSDP) convolutional neural network (CNN) architecture for early-stage AMD diagnosis automatically. The proposed PSDP architecture has nine convolutional layers to classify the input image as AMD or normal. A PSDP architecture is used to enhance classification efficiency due to the high variation in size and shape of perforation present in OCT images. The poly scale approach employs filters of various sizes to extract features from local regions more effectively. Simultaneously, the dual path architecture incorporates features extracted from different CNN layers to boost features in the global regions. The sigmoid function is used to classify images into binary categories. The Mendeley data set is used to train the proposed network and tested on Mendeley, Duke, SD-OCT Noor, and OCTID data sets. The testing accuracy of the network in Mendeley, Duke, SD-OCT Noor, and OCT-ID is 99.73%,96.66%,94.89%,99.61%, respectively. The comparison with alternative approaches showed that the proposed algorithm is efficient in detecting AMD. Despite having been trained on the Mendeley data set, the proposed model exhibited good detection accuracy when tested on other data sets. This shows that the suggested model can distinguish AMD/Normal images from various data sets. As compared to other methods, the findings show that the proposed algorithm is efficient at detecting AMD. Rapid eye scanning for early detection of AMD could be possible with the proposed architecture. The proposed CNN can be applied in real-time due to its lower complexity and less learnable parameters.