bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases
Authors: Sultana Sharmim , Viet Thanh Doan , Amin Tasmiha , Kazi Esha , Micolucci Luigina , Mollah Abul Kalam Mohammad Moniruzzaman , Akhtar Most Mauluda , Islam Md Soriful
Published: November 2023

Inflammasomes, a group of multiprotein complexes, are essential in regulating inflammation and immune responses. Several inflammasomes, including nucleotide-binding domain leucine-rich repeat-containing protein 1 (NLRP1), NLRP3, NLRP6, NLRP7, NLRP12, interferon-inducible protein 16 (IFI16), NOD-like receptor family CARD domain-containing protein 4 (NLRC4), absent in melanoma 2 (AIM2), and pyrin, have been studied in various inflammatory diseases. Activating inflammasomes leads to the processing and production of proinflammatory cytokines, such as interleukin (IL)-1β and IL-18. The NLRP3 inflammasome is the most extensively studied and well characterized. Consequently, targeting inflammasomes (particularly NLRP3) with several compounds, including small molecule inhibitors and natural compounds, has been studied as a potential therapeutic strategy. This review provides a comprehensive overview of different inflammasomes and their roles in six inflammatory diseases, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, atherosclerosis, type 2 diabetes, and obesity. We also discussed different strategies that target inflammasomes to develop effective therapeutics.
Effect of Vacancy, As, and Sb Dopants on the Gold-Capturing Ability of Cu2S during Gold Collection in Matte Processes
Authors: Huang Hui , Xiong Huihui , Gan Lei
Published: November 2023

The technique of gold collection in matte can effectively improve the trapping efficiency of precious metals such as gold, silver, and platinum. However, the underlying mechanism of gold collection from high-temperature molten matte is complex and not well understood. In this work, the first-principle calculations were utilized to investigate the adsorption behavior of gold atoms on a Cu2S surface. The effects of vacancies and As and Sb doping on the gold-trapping ability of Cu2S were also explored, and the electronic properties of each adsorption system, including the charge density difference, density of states, and charge transfer, were systematically analyzed. The results show that the Cu-terminated Cu2S(111) surface has the lowest surface energy, and the Au atom is chemically adsorbed on the Cu2S(111) with an adsorption energy of −1.99 eV. The large adsorption strength is primarily ascribed to the strong hybridizations between Au-5d and Cu-3d orbitals. Additionally, the Cu vacancy can significantly weaken the adsorption strength of Cu2S(111) towards Au atoms, while the S vacancy can notably enhance it. Moreover, due to the formation of strong covalent As–Au/Sb–Au bonds, doping As and Sb into Cu2S(111) can enhance the gold-trapping capability of Cu2S, and the Sb doping exhibits superior effectiveness. Our studied results can provide theoretical guidance for improving the gold collection efficiency of Cu2S.
Inhibitory Activity of 4-Benzylidene Oxazolones Derivatives of Cinnamic Acid on Human Acetylcholinesterase and Cognitive Improvements in a Mouse Model
Authors: Ramírez-Ruiz Alma Marisol , Ávila-Cossío Martha Elena , Estolano-Cobián Arturo , Cornejo-Bravo José Manuel , Martinez Ana Laura , Córdova-Guerrero Iván , Cota-Ramírez Bibiana Roselly , Carranza-Ambriz Krysta Paola , Rivero Ignacio A. , Serrano-Medina Aracely
Published: November 2023

We synthesized seven (Z)-benzylidene-2-(E)-styryloxazol-5(4H)-ones derivatives of cinnamic acid and evaluated the ability of these compounds to inhibit human acetylcholinesterase (hAChE). The most potent compound was evaluated for cognitive improvement in short-term memory. The seven compounds reversibly inhibited the hAChE between 51 and 75% at 300 μM, showed an affinity (Ki) from 2 to 198 μM, and an IC50 from 9 to 246 μM. Molecular docking studies revealed that all binding moieties are involved in the non-covalent interactions with hAChE for all compounds. In addition, in silico pharmacokinetic analysis was carried out to predict the compounds’ blood–brain barrier (BBB) permeability. The most potent inhibitor of hAChE significantly improved cognitive impairment in a modified Y-maze test (5 μmol/kg) and an Object Recognition Test (10 μmol/kg). Our results can help the rational design of hAChE inhibitors to work as potential candidates for treating cognitive disorders.
Bioprotection Potential of Lacticaseibacillus rhamnosus LRH01 and Lactiplantibacillus plantarum LP01 against Spoilage-Associated Penicillium Strains in Yoghurt
Authors: Shi Ce , Knøchel Susanne
Published: November 2023

Penicillium spp. are considered a major spoilage fungus in dairy products. Due to the growing concerns over food safety issues and the demand for “clean label” food products from consumers, the use of lactic acid bacteria (LAB) as a bioprotective tool to control fungal spoilage of dairy products appears to be a promising alternative. Here, the antifungal activities of ten LAB cultures against five dairy-spoilage-associated Penicillium strains were studied in a model system, and the most potent bioprotective cultures were further tested in yoghurt. Lacticaseibacillus rhamnosus (L. rhamnosus) LRH01 and Lactiplantibacillus plantarum (L. plantarum) LP01 exhibited potent antifungal efficacy at low concentrations. The inhibitory effects of cell-containing fermentates (C-fermentates), cell-free fermentates (CF-fermentates), and volatiles produced by the two cultures were tested in a yoghurt serum medium. The C-fermentates showed antifungal effects, while the removal of cells from C-fermentates led to decreased antifungal activities. Volatiles alone displayed some antifungal efficiency, but less than the fermentates. In a yoghurt matrix, the specific effect of manganese depletion by the bioprotective cultures on mold growth was investigated. Here, the LAB cultures could completely suppress the growth of molds, while addition of manganese partially or fully restored the mold growth, demonstrating that manganese depletion played a key role in the antifungal activity of the tested LAB cultures in the yoghurt matrix. Both L. plantarum LP01 and L. rhamnosus LRH01 showed efficient antifungal activities in the yoghurt serum, while L. rhamnosus LRH01 exhibited the most potent inhibitory effects on Penicillium strains when added during the processing of the yoghurt with subsequent storage at 7 °C for 22 days. Our findings suggested that L. rhamnosus LRH01 could be a promising bioprotective culture for yoghurt biopreservation.
Chenopodium album: its nutritional value and use
Authors:   Military Academy of Air and Space Defense named after Marshal of the Soviet Union G.K. Zhukov, Rodionova A.E.
Published: November 2023

The article discusses the use of the weed Chenopodium album (lambsquarters). Its nutritional value, active substances, and recipes for dishes from this plant are given. This allows considering Chenopodium album (lambsquarters) from the perspective of a functional additive in culinary recipes.
Analytical review of methods for determining mechanical damage to buckwheat grain
Authors: Gurieva K.B. , Tarasova E.A. , Khaba N.A. ,   Federal State Budgetary Institution Research Institute for Problems of Storage of the Federal Reserve
Published: November 2023

The article provides an overview of methods used to determine mechanical damage to buckwheat grain and its internal defects. It is shown that the assessment of the qualitative state of buckwheat when stored in elevator silos must be carried out taking into account the presence of damaged grain, which requires the development of objective instrumental methods for determining macro- and microdamage to this crop. Currently, visual methods with pre-processing (under a magnifying glass and microscope) and without pre-processing are used, which are inaccurate. The most advanced method for determining damage to grain and its internal defects is the radiographic method, which requires improvement and automation for cereal crops, in particular for buckwheat.
Study of some predictors of delinquent disorders in patients with organic personality disorder
Authors:   FSBEI HE Rostov State Medical University of the Ministry of Health of the Russian Federation, Khudina Yu. S. , Tkachenko N. V. ,   FSBEI HE Rostov State Medical University of the Ministry of Health of the Russian Federation, Zaika V. G. ,   FSBEI HE Rostov State Medical University of the Ministry of Health of the Russian Federation
Published: November 2023

The problem of antisocial (delinquent) human behavior has existed since ancient times. According to literary sources, adolescents are the most susceptible to this form of behavior, however, this does not always reflect the reality. In psychiatry, it is customary to pay attention not only to age, gender, or nosological aspects, but also to personal characteristics when behavioral disorders occur. This article analyzes predictors of delinquent disorders in patients with organic personality disorder. The age parameters of the disorders presented in the sample are considered: behavioral deviations characteristic of childhood and adolescence, as well as of adults, are described. In addition, personal characteristics influencing the occurrence of delinquent behavior have been studied. It is proposed to introduce a new parameter — locus of control, which allows for a comprehensive assessment of the condition of subjects in different spheres of life.
Una asociación renovada. Balance y perspectivas de la Cumbre UE-CELAC y las relaciones euro-latinoamericanas
Authors: Domínguez Roberto , Sanahuja José Antonio
Published: November 2023

La Cumbre Unión Europea-Comunidad de Estados Latinoamericanos y Caribeños (UE-CELAC) celebrada el 17 y 18 de julio de 2023 en Bruselas marca un punto de inflexión y un nuevo comienzo para las relaciones euro-latinoamericanas. En un contexto internacional de creciente incertidumbre y riesgos, el relanzamiento de estas relaciones se erige como plataforma de beneficio mutuo. En primer lugar, puede servir para ampliar la autonomía y la resiliencia de ambas regiones ante un mundo de creciente rivalidad geopolítica, pero necesitado de gobernanza y reglas. En segundo lugar, puede ser útil para fortalecer la democracia y las sociedades abiertas en ambas regiones, lo que también implica hablar de desarrollo, de políticas públicas eficaces, y de la renovación del contrato social. En tercer lugar, la relación birregional puede contribuir a definir estrategias novedosas de asociación económica y comercial, y de cooperación para relanzar el desarrollo, con una “triple transición” societal: digital, verde y también social, que tanto la UE como América Latina han de abordar. Este Documento de trabajo presenta varias aportaciones de especialistas y figuras académicas, que analizan el estado de las relaciones euro-latinoamericanas tras la celebración de la Cumbre.
Des jeux pour la formation sociale des femmes immigrées
Authors: Riff Alice
Published: November 2023

Dans le numéro 32-33 de Migrants-Formation, consacré en mars 1979 aux « Femmes immigrées et la formation », Alice Riff du Département de la Formation Continue de l'Université des Sciences humaines de Strasbourg avait mentionné l'existence de jeux au cours d'une formation commune aux Françaises, travailleuses familiales, et aux Algériennes. Elle nous explique en quoi consistent certains de ces jeux.
Pour un enseignement des littératures et des cultures d'origine des enfants immigrés
Authors: Langumier Maelise
Published: November 2023

Les difficultés scolaires que rencontrent les enfants étrangers en France ne sont pas uniquement d’ordre linguistique, puisque la plupart d’entre eux maîtrisent bien le français oral. Il me semble que certains blocages scolaires viennent de l’ignorance, et du mépris où l’on tient les valeurs culturelles de leurs familles ; aussi m’est-il apparu important de faire prendre conscience aux enfants de travailleurs immigrés de la richesse de ces valeurs et de faire partager à leurs camarades français le plaisir de cette découverte.

Voici l’expérience que j’ai faite dans ce but durant le troisième trimestre de l’année 1975 dans deux classes de 5e du collège expérimental de Gagny (93) d’un enseignement des œuvres littéraires des pays d’origine.
Jeunes Vietnamiens anciennement et récemment installés en France
Authors: N’guyen-Thi-Chi Lan Myriam
Published: November 2023

Vietnamienne en France, j’ai rencontré pour Migrants-Formation 5 jeunes de 16 à 20 ans dont les parents sont vietnamiens, et un Eurasien de 18 ans. Un garçon et une fille étaient nés au Vietnam, les autres en France. Deux étaient lycéens, leurs camarades, étudiants. L’entretien s’est déroulé en français, car si ces jeunes s’intéressent à la langue et la culture de leur famille, ils les connaissent mal.
Relations interethniques à l'école
Authors: Boitard Olivier
Published: November 2023

Le docteur Olivier Boitard, psychiatre, membre du Comité médico-social pour la santé des migrants, analyse ici, sous l'angle psychologique, les relations inter-ethniques à l'intérieur de l'école et se livre à une réflexion plus générale sur les causes du racisme : peur de la différence mais aussi peur de la ressemblance.
Contre les langues de bois
Authors: Porcher Louis
Published: November 2023

La centration sur l'apprenant implique la nécessité de prendre en compte les représentations de celui-ci, ainsi que les diversités des publics scolaires. L'apprentissage du français, préalable incontournable de l'insertion positive dans le système scolaire, occupe une place capitale. Quels sont alors les questions méthodologiques majeures de l'enseignement des langues aux enfants migrants ?
Paroles d'enfants de travailleurs immigrés, d'enseignants en formation, de formateurs. Ou comment utiliser, pour une fois, les difficultés des immigrés pour réfléchir à la formation des formateurs
Authors: Musy Alain
Published: November 2023

Alain Musy, animateur au CEFISEM de Grenoble, analyse la formation des formateurs d'adultes en mettant en parallèle le discours des enfants de travailleurs immigrés, celui des enseignants en formation et celui des formateurs de formateurs.
Application of promising radio communications in the departments of the internal affairs
Authors:   St. Petersburg University of the Ministry of Internal Affairs of the Russian Federation, Melnikov N.M. , Nikishkin A.V. , Stishak A.A. , Voloshin G.G.
Published: November 2023

Summary: The article deals with topical issues related to the problem of the outdated fleet of portable radio equipment, which are in service with the units of the internal affairs bodies, as well as the variety of technologies on the basis of which portable radio equipment is built. At present, both analog and digital portable radio stations of FM, DMR, TETRA and APCO P25 standards are simultaneously used in the internal affairs bodies. The portable radio communications used are not always able to meet the requirements for the timeliness and security of transmitted and received operationally significant information in the course of operational search activities. Failure to comply with the above requirements will inevitably lead to the impossibility of managing units, and as a result, to the disruption of operational-search activities.
The algorithm for automating the work process of the student palace of culture on the example of the vocal studio
Authors:   Reshetnev Siberian State University of Science and Technology, Ognegina P.S. , Ognegin K.E. , Popov A.A.
Published: November 2023

The purpose of the study is to analyze the work of the Student Palace of Culture (SDK). The article discusses the process of conducting an intra-university event, as well as the formation of accounting documentation by the director of the KFOR. The complexity and volume of work of employees is shown. The topic of student rating for achievements in cultural and creative activities is touched upon. The scientific novelty of the work lies in the absence of existing information systems (IS) that contribute to the automation of the process under consideration. As a result of the research, algorithms were developed that allow automating the process of event planning, as well as the preparation of reporting documentation on them. In addition, the formula for calculating the student›s rating is presented and a table of accrued points for achievement levels is described, which also allows automating this process.
Analysis of threats to interfaces of unmanned vehicles
Authors:   St. Petersburg Federal Research Center of the Russian Academy of Sciences, Kolomeec M.V. , Zhernova K.N. , Chechulin A.A.
Published: November 2023

Statement of the problem: the intelligent environment of a smart city includes many interfaces of various types, many of which are subject to a number of cyber-physical attacks and information security threats. At the same time, unmanned transport technologies are actively developing, and various intellectual infrastructure of a smart city is becoming more widespread. For this reason, attacks on the intelligent environment of a smart city and the issues of their protection are becoming increasingly relevant. The purpose of this work is to review the most relevant threats for various components of an unmanned transport environment and their classification depending on the type of interface and the type of attack, depending on the technology used by each specific component of an unmanned transport environment. Methods used: studying previous scientific papers and reports on the use of various interfaces of the intelligent transport environment of a smart city, as well as reports on previously implemented attacks on these interfaces, systematizing attacks, classifying them depending on the type of attack and type of interface. Novelty: The novelty of the work lies in the presented descriptive model of interaction and classification of the components of an unmanned transport environment. The main contribution lies in the identification of the main threats and their relationship with the components of the unmanned transport environment. Result: the resulting threat classification allows generalizing threats for each component of an unmanned transport environment, which allows developers and computer security specialists to appeal to attacks on a specific interface component of interest for further work with them in order to take the necessary measures to prevent possible threats. A descriptive model of interaction between the components of an unmanned transport environment is proposed. Practical Relevance: The overview presented is summarized in the form of a table, which provides the correspondence of each component of the unmanned vehicle environment with the interface, possible threats and links to previous work and security incident reports for each specific component.
Analytical model of intermodule interactions threats in the information security system
Authors:   National Institute for Development in Information Security, Pokussov V.V.
Published: November 2023

The article synthesizes an analytical model of threats of inter-module interaction in the information security system. For this purpose, a formalization of the latter elementary entities in terms of set theory is introduced: modules, information objects, attacks, and boundaries. The introduced formalization is applied to describe 6 typical threats of information-technical interaction in the information security system, the model of which was obtained earlier. Their brief formulation is given, and the conditions of occurrence in aspects of the introduced and formalized elementary entities are interpreted. For each threat a graphical example of occurrence and its analytical record in the notation of predicate logic are given. The negation operation is applied to the statement “conditions of threat existence”, which allows to obtain formally a way to counteract it, which is interpreted as a requirement to the information security system.
Narrar la historia desde otro lugar. Sobre El tren de la victoria, y el relato de los hermano
Authors: Rosano Susana
Published: November 2023

El tren de la victoria, de Cristina Zuker, lleva por subtítulo precisamente “Una saga familiar” y puede ser leído como una intervención potente en la esfera pública que pretende construir otro archivo en relación con la vida y muerte de su hermano Ricardo, conocido por su nombre de guerra montonero como el Pato. El objetivo de este artículo es indagar en las representaciones que los hermanos tienen acerca de la militancia de la década del 70. La pregunta que nos interpela es si se puede hablar en su caso de una mirada diferencial en el registro de lo que Elizabeth Jelin ha llamado el familismo en las luchas por la legitimidad de la palabra. ¿Es posible desde el lugar de los hermanos deconstruir el archivo que han venido cimentando en Argentina los organismos de derechos humanos y las memorias de la militancia, para ofrecer un conocimiento nuevo?
Memorias del tiempo de inmadurez: Narrativas de formación/aprendizaje - Presentación
Authors: Piacenza Paola , Zamora Alejandro
Published: November 2023

n/a
Biografia, ensaio biográfico, formas anômalas: Notas sobre um percurso de investigação
Authors: Marcos Pereira Antonio
Published: November 2023

No texto a seguir — que se originou em uma apresentação realizada em 2022 na Universidade Nacional de Rosário — apresento um conjunto de indagações que gravitam inicialmente ao redor da questão da forma tradicional da biografia e seus pressupostos, partindo daí para uma tentativa de caracterizar o ensaio biográfico, valorizando as negociações e potenciais fertilizações recíprocas entre o ensaístico e o biográfico. Introduzo também questões relativas à poética da biografia, explorando um percurso de investigação que, nos últimos dez anos, atravessa a tentativa de definir o biográfico, de explorar as hibridações com o ensaio, e de explorar as formas anômalas da biografia. Concluo apresentando o que me parecem horizontes atuas de pesquisa, marcados pela questão da forma, bem como por questões relacionadas às conceitualizações que contribuem para a estruturação da narrativas biográficas, suas poéticas e processos.
Por un mundo más próximo: mapas alterados en la obra de Osvaldo Baigorria
Authors: Adamo Gabriela
Published: November 2023

Este trabajo analiza en conjunto dos libros de Osvaldo Baigorria: la novela Correrías de un infiel y la colección de cuentos Indiada. Traza una línea de continuidad en la forma en que ambas publicaciones despliegan las nociones de individuo, distancia y movimiento, tomando en cuenta el trabajo crítico en torno a estos conceptos que desarrollan corrientes como el posestructuralismo, la biopolítica y los nuevos materialismos. La lectura recorre el modo en que ambos textos se potencian para cuestionar una geografía dada y, a partir de allí, ofrecer modos alternativos de mapear el mundo, es decir, de habitarlo.
Marcos Zangrandi. Los agentes dobles. Rosario, Beatriz Viterbo, 2023, 190 pp.
Authors: Cortés Rocca Paola
Published: November 2023

Reseña sobre Marcos Zangrandi. Los agentes dobles. Rosario, Beatriz Viterbo, 2023, 190 pp.
Analisis Penilaian Persediaan Obat Dengan Menggunakan Metode Fifo Dan Average Di Klinik Idaman As’adiyah Sukorejo Banyuputih Situbondo
Authors: Shoimah Imroatus
Published: November 2023

Penelitian ini bertujuan untuk menganalisis penilaian persediaan obat dengan menggunakan dua metode yakni metode FIFO dan Metode Average di klinik Idaman As’adiyah Sukorejo Banyuputih Situbondo. Berdasarkan  hasil observasi, ada bayak jenis obat yang disiapkan oleh klinik. Akan tetapi hanya 2 (dua) jenis obat yang diputuskan menjadi sampel dalam penelitian ini dengan menggunakan teknik simple random sampling. Hasilnya menunjukkan bahwa penilaian persediaan dengan metode FIFO menunjukkan harga pokok penjualan yang lebih kecil dibandingkan dengan metode Average. Dengan demikian menunjukkan bahwa pengakuan laba kotor metode FIFO lebih besar daripada metode Average. Saran untuk Penelitian selanjutnya adalah memperluas sampel agar mendapatkan hasil yang lebih kuat.
EVALUATION OF THE USE OF THE DRUG IN PATIENTS ACUTE RESPIRATORY TRACT INFECTION (ARI) NON PNEUMONIA AT PUSKESMAS SIGUMPAR
Authors: Sihombing Yanna Rotua , Romauli Anna teresia Marbun  , Friska Novita Pasaribu  , Novidawati Br Situmorang
Published: November 2023

Acute Respiratory Infection (ARI) is one of the main causes of patient visits to health centers (40%-60%) and hospitals (15%-30%). In Indonesia the level of use of antibiotics is still quite high. The unwise use of antibiotics and the incorrect application of standard precautions in health care facilities an lead to the occurrence of resistane. This study aims to determine the evaluation of drug use in non-pneumonia Aucute Respiratory Infection (ARI) patients at the Sigumpar Health Center. This Type of research is an observational study with a descriptive design and data taken retrospectively. The total sample of 101 medical records was taken by purposive sampling technique. The patients who often suffer from non-pneumonia acute respiratory infections at the Sigumpar Health Center occur in the age group of 6-11 years, namely children by 20,79%. Based on the results of this study, the most widely used drugs were analgesic-antipyretic (69.30%), antihistamine (65.34%), vitamins (62.37%), mucolytics (48.51%), expectorants (32.67%), antibiotics (27.72%) and corticosteroids (23.76%). The use antibiotics for non-pneumonia ARI patients at the Sigumpar Health Center was 27,72% so that it was categorized as not in accordance with the provisions of the Inonesian Ministry of Health in 2017 that the use of antibiotics in non-pneumonia ARI patients was ? 20%.
FORMULATION AND TEST INHIBITORY EFFECT OF MUSHROOMS CREAM PREPARATION ETHANOL EXTRACT AVOCADO SEEDS (PERSEA AMERICANA MILL) AGAINST MALASSEZIA FURFUR IN VITRO
Authors: Turnip Nur Ulina M. Br. , Novandi Purba  , Novidawati Boru Situmorang  , Sarah Gabetta br Napitupulu
Published: November 2023

Biji alpukat (Persea americana Mill) merupakan limbah rumah tangga yang memiliki kandungan metabolit sekunder yang dapat berperan sebagai antijamur. Antijamur ekstrak etanol biji alpukat (Persea americana Mill) murni sudah diuji dan menunjukkan adanya daya hambat terhadap jamur Malassezia furfur. Panu adalah salah satu penyakit yang dapat di obati karena infeksi Malassezia furfur, pengobatan pada penyakit kulit umumnya menggunakan sediaan setengah padat seperti krim. Metode yang digunakan pada uji daya hambat krim ekstrak etanol biji alpukat (Persea americana Mill) terhadap Malassezia furfur adalah difusi cakram. Krim ekstrak etanol biji alpukat (Persea americana Mill) yang di uji menggunakan krim dengan konsentrasi 20% atau 10 gram, konsentrasi 40% atau 20 gram, konsentrasi 60% atau 30 gram dan kontrol positif Ketoconazole 2%.Hasil penelitian menunjukkan bahwa krim ekstrak etanol biji alpukat (Persea americana Mill) dengan kadar ekstrak 20%, 40%, dan 60% memberikan daya hambat dengan kategori sedang.
ANALYSIS OF DATA ON PROCUREMENT AND USE OF INSULIN IN DIABETES MELLITUS PATIENTS AT THE GENERAL HOSPITAL Dr. FL TOBING SIBOLGA
Authors: Hasni Hasni Yaturramadhan Harahap , Sofyan Syarifuddin  , Debi Meilani  , Deliwarni Rajagukguk  , Fatimah Sari Simatupang  , Reni Aprinawaty Sirait
Published: November 2023

Abstrak

Pengelolaan obat merupakan merupakan sebuah rangkaian pengendalian obat mulai dari proses seleksi, pengadaan, distribusi, hingga penggunaan. Pengelolaan obat berhubungan erat dengan anggaran dan belanja instalasi kesehatan seperti rumah sakit, puskesmas, dan apotek.Tujuan penelitian ini untuk kesesuaian pengadaan insulin di RSU. Dr. FL. Tobing Sibolga dengan kebutuhan pasien diabetes mellitus pada Tahun 2022. Metode penelitian ini meliputi penelitian deskriptif yaitu dengan melihat laporan pemakaian dan lembar permintaan insulin di RSU Dr. FL. Tobing Sibolga. Hasil penelitian menunjukkan Pengadaan Insulin pada Rumah Sakit FL. Tobing telah sesuai dengan kebutuhan/pemakaian insulin sepanjang Tahun 2022 dikarenakan Jumlah Pengadaan lebih besar dibandingkan dengan kebutuhan. Dan Hal ini tidak terdapat perbedaan signifikan jumlah insulin yg direncanakan dengan kebutuhan insulin sepanjang Tahun 2022.

 

Kata kunci: Pengelolaan, Penggunaan, Kesesuaian

 

Abstract

Drug management is a series of drug control starting from the process of selection, procurement, distribution, to use. Drug management is closely related to the budget and expenditure of health installations such as hospitals, health centers, and pharmacies. The aim of this study is to determine the suitability of insulin procurement in public hospitals. Dr. FL. Tobing Sibolga with the needs of diabetes mellitus patients in 2022. This research method includes descriptive research, namely by looking at usage reports and insulin request sheets at RSU Dr. FL. Tobing Sibolga. The results of the study showed that insulin was procured at the FL Hospital. Tobing is in accordance with the need/use of insulin throughout 2022 because the amount of procurement is greater than the need. And there is no significant difference in the planned amount of insulin and insulin needs throughout 2022.

 

Keywords: Management, Use, Appropriateness
LIP BALM PREPARATION FORMULATION CORIANDRUM LEAF EXTRACT (CORIANDRUM SATIVUM L.) AS A MOUSTURIZING LIPS*
Authors: Wulandari Suci , Hasanah Fitria  , Siti Wahyuni
Published: November 2023

Leaf coriander (Coriandrum sativum L.) known own activity high antioxidants Lip balms is Wrong One preparations pharmaceutical form product functional beauty For help increase humidity on lips. Leaf coriander can made as substance active addition on lip balm formulas. it become reason use lip balms in study this. Study This aim For know is extract leaf coriander (Coriandrum sativum L.) can formulated become preparations lip balms And For know difference variation concentration extract leaf coriander (Coriandrum sativum L.) can influential as moisturizer on preparations lip balms Manufacturing process extract ethanol leaf coriander with method maceration use solvent 96% ethanol. preparation lip balms made in 4 formulas viz each with concentration extract leaf coriander 0% (F1), 5% (F2), 10% (F3), and 15% (F4). Testing to preparations lip balms covers test homogeneity , pH test , test stability for 4 weeks, test irritation , and test humidity to lips volunteer use tool skin analyzer with the parameters being measured covers moisture (water content). Maintenance done during four Sunday with use lip balms every a week once. Results study show that all preparations lip balms characteristic homogeneous , pH 7, shape , color , and the smell stable during storage And No irritate skin. Results measurement humidity show that lip balms extract ethanol leaf coriander 15% can increase the most moisture (water content). Extract ethanol leaf coriander (Coriandrum sativum L.) 15% in preparations lip balms more Good in increase moisture (water content) compared with extract ethanol leaf coriander 0%, 5% and 10%. Lip balms comparison show activity more moisture (moisture content). Good compared to with lip balms extract ethanol leaf coriander 15%.
The Effect of Dismenorerage Exercise on Dysmenorerage in Adolescent Women in Bah Jambi Private Junior High School
Authors: Saputri Ika Nur , Pasaribu Yoma Yopa Ate Malem
Published: November 2023

Dysmenorrhea is pain during menstruation that is felt in the lower abdomen and also in muscle pain in the upper thighs, lower back, pelvis, and waist to calves. Dysmenorrhea also affects emotions and anxiety due to feelings that are uncomfortable and foreign to adolescents. Therefore dysmenorrhea must be handled so that these impacts can be minimized. Every year, dysmenorrhea is a problem that always arises among women of childbearing age. This research was conducted because there was data from a preliminary study and it was found that 90% of young women experienced dysmenorrhea, namely in young women at Bah Jambi Private Middle School. The purpose of this study was to determine the effect of dysmenorrhea exercise on menstrual pain (dysmenorrhea) in young women at Bah Jambi Private Middle School. Quasi-experimental research with a one-group pre-test post-test design scheme. A total of 37 young women were selected to be the sample, which was determined by purposive sampling. The resulting data in the form of a search scale will be analyzed using the Wilcoxon Sign Rank Test. The pain scale before the dysmenorrhea exercise showed that most of the respondents experienced menstrual pain that interfered with their activities. After doing the exercise, the menstrual pain for young women becomes a little painful. Based on the Wilcoxon Sign Rank Test with a 95% level of confidence, the value of p = 0.00 is obtained, where this value is less than 0.05, which means that the alternative hypothesis is accepted. So it can be concluded that dysmenorrhea exercise affects reducing menstrual pain in young women at Bah Jambi Private Middle School.
The Relationship Between Lato-Lato Games And Decreased Gadget Use In Elementry School Age Children In Jati Kesuma village, Namorambe District Deli Serdang District, North Sumatera Province
Authors: Samura Maximilianus Dasril , Indah Febi Claudia
Published: November 2023

The development of an increasingly advanced era at this time resulted in more and more changes that occur in people's lives. In the current era of globalization, there are many types of developments ranging from developments in science, technology to political, economic and cultural developments. Technology that is very popular in this era of globalization is gadget. Gadgets were once only used by the upper middle class, but their use is now used by various groups, ranging from early childhood to adults.

The research method used in this study is an analytical survey with a cross sectional approach. namely research that emphasizes the time of measurement or observation of data on the dependent variable and the independent variable is calculated at the same time or once. Factors that influence the level of lato-lato play with the use of gadgets include: parental age, parental education, child age and child gender. The results of statistical tests using the Chi Square test obtained a p value of

0.002. So that the p value ? 0.05. Based on statistical tests, it can be seen that there is a significant relationship between lato-lato games and decreased gadget use in elementary school-age children in Jati Kesuma Village, Namorambe District, so that the results of statistical tests can be interpreted as Ho is rejected.

And from the results of the above research, it can be suggested to parents to be aware of their children in the use of gadgets and more suggest to children to play games that can stimulate motor development and social development of children in the future.
The Effect of Motor Relearning Program on Daily Living Activity and Dynamic Balance in Non-Hemorrhagic Post Stroke Hemiparese Patients at Grandmed Lubuk Pakam Hospital
Authors: Jehaman Isidorus , Br Siagian Khairunnisa , Bintang Siti Sarah , Ginting Raynald Ignasius , Ginting Rosita
Published: November 2023

Stroke is a functional disorder of the brain that can occur suddenly or abruptly with focal or global neurological signs that can last 24 hours or more (if no surgery or death occurs) without any signs of non-vascular causes, which include signs of subarachnoid hemorrhage, intracerebral hemorrhage, ischemia or cerebral infarction. This can cause disturbances in vital brain functions such as coordination disorders, balance disorders, posture control disorders, sensation disorders and movement reflex disorders, thereby reducing the ability to carry out daily living activities and balance disorders. The motor relearning program method is a program for retraining specific motor controls by avoiding unnecessary or wrong movements that involve cognitive processes, the application of motor and psychological science, training, understanding of nervous anatomy and physiology and is not based on the theory of normal development (neuro development). The research aims to determine the effect of the motor relearning program on daily living activities and dynamic balance disorders in post-stroke patients. The method used in this research is a quasi experiment with one group pretest and post test design. The research sample consisted of 9 people. The samples will be observed and adjusted to the specified criteria so that they do not cause problems. Each respondent was measured 2 (two) times, namely before and after the intervention. Test the hypothesis using the Wilcoxon test. The research results obtained a value of p = 0.000 (p=<0.05), which means there is a significant influence of the motor relearning program intervention on daily living activities and dynamic balance disorders in post-stroke patients. The results of this research can be concluded that the motorbike relearning program can improve daily living activities and dynamic balance disorders in patients after non-hemorrhagic stroke. It is hoped that the results of this research can contribute to health services for the community in overcoming the problems of daily living activities and dynamic balance disorders in post-stroke patients.
DETERMINANTS OF INPATIENT SATISFACTION IN FOOD SERVING AND FOOD SERVICE AT MELATI HOSPITAL TANGERANG
Authors: Nafi'a Zidni Ilma , Suryani Dyah , Solikhah Solikhah
Published: November 2023

Hospital is one of the health service industries that has an important role in providing health services to the community. One of the services at the hospital is hospital nutrition service activities which consist of outpatient nutrition care, inpatient nutrition care, food administration, and research and development. Many parties often pay attention to the organization of food in hospitals, in this case, inpatient food services because it is related to patient satisfaction. This study aims to determine the determinants associated with inpatient satisfaction in serving and serving food. The research method used is the chi-square correlation. The sample in this study were inpatients at Melati Hospital Tangerang, totaling 193 patients. The sampling technique used purposive sampling and was taken using a questionnaire. The significance values of the variables age, gender and education were 0.035, 0.048 and 0.018 less than ? (0.05) while the significance values of the variables of work and type of diet were 0.637 and 0.642 more than ? (0.05). This study obtained the results that there was a significant relationship between age, gender and education with service satisfaction and food serving, while work and type of diet did not have a significant relationship with food serving and service.

Keywords: Food Service, Food Serving, Patient Satisfaction, Chi-square
ANALYSIS OF CASE MANAGER FUNCTIONS IN IMPROVING QUALITY CONTROL AND COST CONTROL OF INPATIENT (CASE STUDY) AT GRANDMED HOSPITAL LUBUK PAKAM
Authors: Fitri Maya Sari Panjaitan  , Kasim Felix , Br Ginting Munthe Novita
Published: November 2023

Abstract

The hospital has a process for implementing continuity of care in the hospital and integration between care-giving professionals (PPA) assisted by a patient service manager (MPP)/case manager. The current challenge that must be faced by hospitals in implementing the JKN program is implementing good quality control and cost control. The existence of MPP in the hospital case management system is expected to be able to support quality control and cost control. The purpose of this study was to analyze the functions of the case manager in improving quality control and cost control for inpatients (case study). This research was conducted at the Grandmed Lubuk Pakam Hospital, Deli Serdang Regency from September 2022 to May 2023. The type of research in this study was qualitative. The sample in this study were case managers at Grandmed Lubuk Pakam Hospital, Deli Serdang Regency, totaling 3 people and 1 director of medical services and 3 heads of inpatient rooms. The results showed that the implementation of case managers in improving quality control and cost control for inpatients was quite good. The case manager utility assessment has not gone well because there is no clear format for the initial screening of patients. Patient care planning by case managers has not been maximized. Not all case managers do patient care planning. The case manager's facilitation and advocacy has not been maximized. There are 2 case managers who do not coordinate with other fields, only coordinate with DPJP and nurses. The case manager evaluation has not gone well because there is no instrument format for case manager tasks so evaluation cannot be carried out. Post-discharge planning follow-up by the case manager has not gone well because the case manager has never followed up post-discharge planning. Case managers should carry out case manager functions for patients who are being treated in case management in accordance with the standard criteria set by STARKES 2022 accompanied by proper and accurate documentation to improve service quality and patient satisfaction.

 

Keywords            : Functions, Case Manager, Quality Control, Cost Control, Hospitalization, Case Study
STUDY OF HEAD OF MEDICAL SERVICE SUPERVISION AND INPATIENT NURSE PERFORMANCE ON PATIENT SAFETY AT AEK KANOPAN HOSPITAL NORTH LABUHAN BATU
Authors: Sarasani Theresia , Sitorus Rotua Sumihar , Karo-karo Tati Murni
Published: November 2023

The problem of nurse performance is still an issue in various countries. The performance of nurses always attracts attention in Indonesia. The Province of North Sumatra even stated that the performance of nurses decreased, from 0.52 in 2013 to 0.48 in 2014, and continued to decline until 2015. Good nurse performance is a determining factor for the reputation of a hospital before the community in achieving success. Supervision by the head of the nurse's work unit is a problem related to the nurse's performance appraisal process. This study uses a quantitative approach, observational, with a cross-sectional design. The research sample consisted of 64 nurses in the Inpatient Installation of Aek Kanopan Hospital who were selected according to the criteria. The research data obtained were analyzed using univariate analysis which aims to describe the frequency distribution related to supervision data, Nurse Work Performance, and Patient Safety Implementation. Bivariate analysis which aims to prove the relationship between supervision and nurse performance on the implementation of patient safety uses Pearson's correlation with a 95% confidence level. There is a relationship between clinical supervision on the overall performance of nurses with a Pearson Chi-Square value = 5.146 and a p = 0.023 (p <0.05). In addition, there is also a relationship between the overall performance of inpatient nurses on the implementation of inpatient safety, with a Pearson Chi-Square value of 12.292 and a value of p = 0.000* (p <0.05). The better the performance of the nurse in the inpatient room, the implementation of inpatient patient safety will also be better.
THE RELATIONSHIP BETWEEN BODY MASS INDEX (BMI) AND HYPERTENSION ON ELDERLY IN MUHAMMADIYAH REGIONAL LEADERS OFFICE (PDM) OF SLEMAN
Authors: Ega Via Ambarwati  , Indriani  , Agus Riyanto
Published: November 2023

Abstract

Background: Hypertension is a non-communicable disease (NCD) which is the main cause of death globally. The prevalence of hypertension continues to increase and is often known as "The Silent Killer". The obesity factor (BMI>25) is also one of the causes of hypertension. Objective: The aim of this study is to assess the correlation between Body Mass Index (BMI) and the incidence of hypertension in the elderly population living in the Muhammadiyah Regional Leadership (PDM) Sleman area. Method:This research is an observational analysis with a cross-sectional approach. The sample consisted of 110 people using purposive sampling. The instruments used include digital scales, microtoise staturemeter and digital sphygmomanometer. Data analysis using univariate and bivariate analysis methods using the Chi Square correlation test. Results : The results of the analysis show that the majority of respondents have characteristics, namely: 49.1% aged 45-59 years, 86.4% are women, 45.5% have secondary education, 51.8% work as housewives, 50.0% experience obese and 82.7% suffered from grade I hypertension. A significant correlation between BMI and blood pressure was identified (P<0.001). Conclusion:A significant correlation was detected between BMI and blood pressure with increasing BMI associated with increasing blood pressure in the elderly. Suggestion: Can collaborate with relevant universities regarding health checks so that they can control the health of congregation members.

 

Key words : Body Mass Index (BMI), Hypertension
THE INFLUENCE OF THE SOCIAL ENVIRONMENT ON MOTHER'S COMPLIANCE IN IMPLEMENTING BASIC IMMUNIZATION IN BABIES
Authors: Yanti Dian Anggri
Published: November 2023

The immunization program aims to control the health and safety rates of children under five from the threat of various diseases related to infection. Very often, mothers are disobedient in immunizing their babies because they are influenced by perceptions or views from the social environment. The social environment exists in the family, peers and neighbors which can influence the attitudes and actions of a person or group in carrying out an activity. Meanwhile, immunization is very important for babies in an effort to prevent disease and increase toddlers' immunity. This type of research is descriptive quantitative research using a cross-sectional approach, which aims to describe the situation in depth and systematically. The sample consisted of 30 mothers. The instrument used was a questionnaire to measure social environmental factors and maternal compliance with basic immunization. The research data obtained was analyzed using univariate and bivariate analysis. The research results showed that as many as 11 mothers (36.7%) who were in a good social environment tended to comply with the implementation of infant immunization. Meanwhile, 16 mothers (53.3%) who were in poor social environments tended to be disobedient to the implementation of infant immunization. The p value of 0.000 < 0.05 in the chi-square test shows that the social environment has a significant effect on maternal compliance in implementing basic immunization for babies in Sidodadi Ramunia Village. Mothers who live in a good social environment tend to comply with the implementation of infant immunization.
EFFECTS OF SODIUM INTAKE AND SMOKING HABITS ON THE BLOOD PRESSURE OF CORONARY HEART PATIENTS AT GRANDMED LUBUK PAKAM HOSPITAL
Authors: Panjaitan Raini , Reni Novia  , Andreais Boffil Cholilluloh  , Adelina Sri Dewi Karo-Karo  , Edarni Zebua
Published: November 2023

Penyakit jantung koroner (PJK) salah satu jenis penyakit degeneratif penyebab kematian. Faktor resiko pjk yaitu tekanan darah tinggi yang merupakan penyebab beban kerja jantung menjadi berat bagi pasien pjk. Kenaikan tekanan darah pada pasien pjk adalah asupan natrium dan kebiasaan merokok. Tujuan penelitian ini adalah untuk mengetahui hubungan asupan natrium dan kebiasaan merokok pada tekanan darah pasien jantung koroner di Rumah Sakit Granmed Lubuk Pakam. Jenis penelitian ini adalah penelitian kuantitatif dengan rancangan cross sectional. Variabel dalam penelitian ini terdiri dari variabel independen yaitu asupan natrium, dan kebiasaan merokok, serta variabel dependen yaitu tekanan darah pada pasien penyakit jantung koroner. Populasi adalah pasien jantung koroner di Rumah Sakit Grandmed Lubuk Pakam. Sampel pada penelitian ini berjumlah 47 responden. Hasil menunjukkan bahwa distribusi kelompok usia paling banayak 38-48 tahun (44,7%), jenis kelamin paling banyak laki-laki (70,2%), tingkat pendidikan terakhir paling banyak SMA (55,3%), tekanan darah responden paling banyak pre hipertensi dan hipertensi derajat 1 (27,7%), asupan natrium responden tergolong tinggi (55,3%), responden memiliki kebiasaan merokok sedang (42,6%). Berdasarkan hasil uji statistik didapatkan ada hubungan yang signifikan antara asupan natrium (p-value =0,003) dan kebiasaan merokok (p-value =0,030) dengan tekanan darah pasien jantung koroner.