bluuebunny/crossref_metadata_2025 huggingface dataset:
TINGKAT KEPUASAN PELANGGAN TERHADAP KUALITAS PELAYANAN PADA GANDRIAL COFFESHOP DI KECAMATAN MAKALE KABUPATEN TANA TORAJA
Authors: Esra Tandira’ba  , Dina Ramba  , Yohanis Lotong Ta’dung  , Westerini Lusdani
Published: March 2023

Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pelanggan terhadap kualitas pelayanan pada Gandrial Coffee Shop di Kecamatan Makale Kabupaten Tana Toraja. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif kualitatif. Teknik pengumpulan data yang digunakan yaitu dengan penelitian kepustakaan dan penelitian lapangan melalui prosedur pengumpulan data yaitu observasi, wawancara, kuesioner dan dokumentasi. Teknik analisis data yang digunakan yaitu menggunakan rumus CSI dil lengkapi dengan tabel customer satisfaction index (CSI). Hasil dari penelitian ini yaitu 82% menunjukkan bahwa tingkat kepuasan pelanggan terhadap kualitas pelayanan pada Gandrial Coffee Shop di Kecamatan Makale Kabupaten Tana Toraja berada pada kategori sangat puas.
IMPLIKASI DIGITAL MARKETING TERHADAP PENJUALAN PRODUK KUE BAWANG JADUL
Authors: Satriadi Satriadi  , Lukman Hidayat  , Fhira Desvika  , Mayang Sari  , Sandri Zuntika
Published: March 2023

Media promosi memiliki dampak yang besar terhadap Usaha Mikro Kecil Menengah (UMKM). UMKM harus mampu beradaptasi dengan kondisi tersebut. UMKM Kue Bawang Jadul merupakan UMKM yang ada di Kota Tanjungpinang. Untuk menghadapi kondisi ini, UMKM Kue Bawang jadul memiliki beberapa permasalahan. Permasalahannya adalah media pemasaran yang digunakan hanya sebatas whatsapp dan hanya menggunakan teknis word of mouth sehingga UMKM kurang berkembang. Penelitian ini dilakukan untuk mengetahui pengaruh media promosi terhadap peningkatan penjualan yang dilakukan oleh UMKM Kue Bawang Jadul. Metode yang digunakan kualitatif untuk memberikan informasi yang komprehensif  kepada peneliti, teknik analisa yang digunakan dalam penelitian ini adalah deskriptif dan metode pengumpulan data menggunakan Interview. Lalu menggunakan uji triangulasi untuk mengetahui data valid atau tidak. Hasil Penelitian ini menunjukkan bahwa pemasaran yang dilakukan pada UMKM Kue Bawang Jadul tidak ada peningkatan yang signifikan. Kemudian perbaikan media pemasaran yang harus dilakukan oleh UMKM Kue Bawang Jadul ialah memperluas pemasaran melalui media digital lainnya seperti Instagram, Facebook, dan beberapa marketplace yang tersedia dalam upaya peningkatan penjualan.
Dampak Pandemi Covid-19 Dan Kreativitas Guru Dalam Pembelajaran Di Indonesia
Authors: Syamsul Muhammad Ayyub
Published: March 2023

The presence of the Covid-19 pandemic has raised problems in Indonesia's education world. The policy to implement fruitful learning from home is a challenge in carrying out effective learning. An overview of learning in the era of the covid pandemic can be seen from the learning at the end of the 2019/2020 school year from various surveys conducted. The existence of simple online learning and learning that emphasizes giving assignments makes students experience learning boredom. Teacher creativity in carrying out solutive learning is needed through online learning with various complex platforms and offline learning.
Nilai Sosial Dalam Novel Laut Bercerita Karya Leila S. Chudori
Authors: Yadia Rahma  , Dewi Anggraini
Published: March 2023

Menambah pengetahuan dari berbagai sumber. Salah satunya dengan sastra. Karya sastra adalah suatu bentuk gagasan, emosi, atau masalah hidup yang dikemas oleh pengarangnya. Jenis penelitian ini adalah kualitatif dengan metode deskriptif. Sumber data  penelitian ini adalah novel Laut Bercerita karya Leila S. Chudori. Data dalam survei ini berupa kalimat atau ucapan yang mengandung nilai sosial. Teknik pengumpulan data dalam penelitian ini adalah studi kepustakaan. Studi kepustakaan dilakukan untuk memperoleh bahan dan informasi terkait penelitian seperti buku, artikel, dan dokumen lain yang berhubungan dengan penelitian. Teknik analisis data adalah dengan membaca dan mencatat.Tujuan dari penelitian ini adalah untuk menjelaskan nilai-nilai sosial yang terdapat pada novel Laut Bercerita karya Leila S. Chudori. Berdasarkan hasil penelitian dan pembahasan bahwa novel Laut Bercerita karya Leila S. Chudori menyuguhkan suatu cerita yang inspiratif, menyentuh perasaan, dan memberikan nilai sosial. Nilai sosial yang terdapat daalam novel Laut Bercerita antara lain: 1) Kejujuran, 2) Kekeluargaan, 3) Tolong Menolong, 4) kerja sama, 5) Kepedulian
A IMPORTÂNCIA DA GESTÃO DE CUSTOS PARA AS COOPERATIVAS DA AGRICULTURA FAMILIAR
Authors: Matos Carlos Leandro da Silva , Lopes Marcio Caetano de Azevedo , Carneiro Etiene Santiago , Silva Adriana Carneiro da
Published: March 2023

As cooperativas da agricultura familiar são um importante setor da economia, sendo uma grande referência no setor agropecuário, por abastecer a mesa de milhões de brasileiros com uma diversidade de produtos alimentares e por se apresentar como fonte de trabalho e renda à muitas famílias agricultoras, além de estimular o desenvolvimento socioeconômico de várias regiões. Desse modo, é importante que as cooperativas desenvolvam uma gestão de custos no sentido de manter a sua sustentabilidade econômica e financeira. Assim, o objetivo deste estudo é demonstrar a importância da gestão de custos para as cooperativas da agricultura familiar. Para o alcance desse objetivo, utilizou-se literatura especializada com base em artigos, livros, Trabalhos de Conclusão de Curso, entre outros. A partir das discussões abordadas, percebeu-se que uma gestão de custos adequada pode oferecer informações precisas sobre custos nas atividades desenvolvidas, além de ser uma excelente fonte de informação para a tomada de decisões de cunho gerencial nas cooperativas da agricultura familiar. A análise aqui apresentada demonstra limitado referencial bibliográfico sobre o tema e a necessidade da superação de determinados obstáculos que inviabilizam o uso dos sistemas de custeio nas cooperativistas.
ABSTRACT: Family farming cooperatives are an important sector of the economy, being a great reference in the agricultural sector, for supplying the table of millions of Brazilians with a diversity of food products and for presenting themselves as a source of work and income for many farming families, in addition to to stimulate the socioeconomic development of various regions. Thus, it is important that cooperatives develop cost management in order to maintain their economic and financial sustainability. Thus, the aim of this study is to demonstrate the importance of cost management for family farming cooperatives. To achieve this objective, specialized literature based on articles, books, Course Conclusion Works, among others, was used. From the discussions discussed, it was realized that proper cost management can provide accurate information about costs in the activities developed, in addition to being an excellent source of information for decision-making of a managerial nature in family farming cooperatives. The analysis presented here demonstrates limited bibliographic reference on the subject and the need to overcome certain obstacles that make the use of costing systems unfeasible in cooperativists.
Keywords: Accounting. Rural. Sustenable.
Disproportions in socio-economic development of the Lower Silesian Voivodeship with particular emphasis on post-mining areas
Authors: Rynio Dorota , Zakrzewska-Półtorak Alicja
Published: March 2023

The Lower Silesian Voivodeship is a region with relatively high social and economic disproportion between its territorial units. This diversification is due to many factors, including specialization, long-term mono-branching and ties with traditional sectors characterised by capital intensity, huge involvement of natural resources, low efficiency and negative environmental effects. The aim of the study is to determine what are the disproportions in the socio-economic development of Lower Silesia and whether the activation of post-mining areas in this region requires support as part of integrated just transition planning.
Traumatic hematoma-based pseudoaneurysm of the superficial temporal artery in a 7-year-old boy: a case report
Authors: Park Dae Hwan , Lee June Key , Baik Bong Soo , Yang Wan Suk , Kim Sun Young
Published: March 2023

The superficial temporal artery (STA), the terminal branch of the external carotid artery, is divided into the frontal (anterior) and parietal (posterior) branches. The frontal branch of the STA is located superficially on the anterior region of the scalp, making it especially susceptible to trauma. Here, we report a traumatic pseudoaneurysm of the STA in a 7-year-old boy who was injured in a minor car accident. A physical examination showed only a small bruise on the patient’s forehead, and all vital signs were stable at the emergency room of our medical center. A facial computed tomography scan showed no significant findings. However, the boy later re-visited the hospital with slight swelling on the right forehead, and an ultrasonography scan revealed a hematoma near the right temporal artery. The resected hematoma (approximately 2 cm) was diagnosed as a traumatic pseudoaneurysm. Awareness of the possibility of a traumatic pseudoaneurysm in the STA may prevent a circumspect diagnosis in the future.
Discrepancy of the location of depression on the soft tissue and the bone in isolated zygomatic arch fracture
Authors: Lee Yong Jig , Han Dong Gil , Kim Se Hun , Shim Jeong Su , Kim Sung-Eun
Published: March 2023

Background: When performing reduction of zygomatic arch fractures, locating the inward portion of the fracture can be difficult. Therefore, this study investigated the discrepancy between the locations of the depression on the soft tissue and bone and sought to identify how to determine the inward portion of the fracture on the patient’s face.Methods: We conducted a retrospective review of chart with isolated zygomatic arch fractures of type V in the Nam and Jung classification from March 2013 to February 2022. For consistent measurements, a reference point (RP), at the intersection between a vertical line passing through the end point of the root of the ear helix in the patient’s side-view photograph and a transverse line passing through the longest horizontal axis of the external meatus opening, was established. We then measured the distance between the RP and the soft tissue depression in a portrait and the bone depression on a computed tomography (CT) scan. The discrepancy between these distances was quantified.Results: Among the patients with isolated zygomatic arch fractures, only those with a fully visible ear on a side-view photograph were included. Twenty-four patients met the inclusion criteria. There were four types of discrepancies in the location of the soft tissue depression compared to the bone depression: type I, forward and upward discrepancy (7.45 and 3.28 mm), type II, backward and upward (4.29 and 4.21 mm), type III, forward and downward (10.06 and 5.15 mm), and type IV, backward and downward (2.61 and 3.27 mm).Conclusion: This study showed that discrepancy between the locations of the depressions on the soft tissue and bone exists in various directions. Therefore, applying the transverse and vertical distances measured from a bone image of the CT scan onto the patient’s face at the indicated RP will be helpful for predicting the reduction location.
Un matrimonio intertextual. "Correo del domingo": textos, imágenes y cultura visual en Buenos Aires, 1864-1868
Authors: Andrés Masán Lucas
Published: March 2023

En este artículo analizamos el semanario literario "Correo del domingo" y su impacto en la conformación de una nueva cultura visual en Buenos Aires durante la década de 1860. Partimos de considerar la publicación en sus aspectos textual e icónico, entendida como termómetro de las reconfiguraciones que operaron en el ámbito visual y como un artefacto que condensó los trastocamientos de la faz perceptiva en una ciudad que promocionaba nuevas miradas e interpelaba al régimen de la visión.
Milk and Honey
Authors: Novick Tamar
Published: March 2023

An innovative historical analysis of the intersection of religion and technology in making the modern state, focusing on bodily production and reproduction across the human-animal divide.

In Milk and Honey, Tamar Novick writes a revolutionary environmental history of the state that centers on the intersection of technology and religion in modern Palestine/Israel. Focusing on animals and the management of their production and reproduction across three political regimes—the late-Ottoman rule, British rule, and the early Israeli state—Novick draws attention to the ways in which settlers and state experts used agricultural technology to recreate a biblical idea of past plenitude, literally a “land flowing with milk and honey,” through the humanimal body.

Novick presents a series of case studies involving the management of water buffalo, bees, goats, sheep, cows, and people. She traces the intimate forms of knowledge and bodily labor—production and reproduction—in which this process took place, and the intertwining of bodily, political, and environmental realms in the transformation of Palestine/Israel. Her wide-ranging approach shows technology never replaced religion as a colonial device. Rather, it merged with settler-colonial aspirations to salvage the land, bolstering the effort to seize control over territory and people.

Fusing technology, religious fervor, bodily labor, and political ecology Milk and Honey provides a novel account of the practices that defined and continue to shape settler-colonialism in the Palestine/Israel, revealing the ongoing entanglement of technoscience and religion in our time.
Molecular World
Authors: Jackson Catherine M.
Published: March 2023

A compelling and innovative account that reshapes our view of nineteenth-century chemistry, explaining a critical period in chemistry's quest to understand and manipulate organic nature.

According to existing histories, theory drove chemistry's remarkable nineteenth-century development. In Molecular World, Catherine M. Jackson shows instead how novel experimental approaches combined with what she calls “laboratory reasoning” enabled chemists to bridge wet chemistry and abstract concepts and, in so doing, create the molecular world. Jackson introduces a series of practice-based breakthroughs that include chemistry's move into lampworked glassware, the field's turn to synthesis and subsequent struggles to characterize and differentiate the products of synthesis, and the gradual development of institutional chemical laboratories, an advance accelerated by synthesis and the dangers it introduced.

Jackson's historical reassessment emerges from the investigation of alkaloids by German chemists Justus Liebig, August Wilhelm Hofmann, and Albert Ladenburg. Stymied in his own research, Liebig steered his student Hofmann into pioneering synthesis as a new investigative method. Hofmann's practice-based laboratory reasoning produced a major theoretical advance, but he failed to make alkaloids. That landmark fell to Ladenburg, who turned to cutting-edge theory only after his successful synthesis.

In telling the story of these scientists and their peers, Jackson reveals organic synthesis as the ground chemists stood upon to forge a new relationship between experiment and theory—with far-reaching consequences for chemistry as a discipline.
RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections
Authors: Lace Beatrice , Su Chao , Invernot Perez Daniel , Rodriguez-Franco Marta , Vernié Tatiana , Batzenschlager Morgane , Egli Sabrina , Liu Cheng-Wu , Ott Thomas
Published: March 2023

Host-controlled intracellular accommodation of nitrogen-fixing bacteria is essential for the establishment of a functional Root Nodule Symbiosis (RNS). In many host plants, this occurs via transcellular tubular structures (infection threads - ITs) that extend across cell layers via polar tip-growth. Comparative phylogenomic studies have identified RPG (RHIZOBIUM-DIRECTED POLAR GROWTH) among the critical genetic determinants for bacterial infection. In Medicago truncatula, RPG is required for effective IT progression within root hairs but the cellular and molecular function of the encoded protein remains elusive. Here, we show that RPG resides in the protein complex formed by the core endosymbiotic components VAPYRIN (VPY) and LUMPY INFECTION (LIN) required for IT polar growth, co-localizes with both VPY and LIN in IT tip- and perinuclear-associated puncta of M. truncatula root hairs undergoing infection and is necessary for VPY recruitment into these structures. Fluorescence Lifetime Imaging Microscopy (FLIM) of phosphoinositide species during bacterial infection revealed that functional RPG is required to sustain strong membrane polarization at the advancing tip of the IT. In addition, loss of RPG functionality alters the cytoskeleton-mediated connectivity between the IT tip and the nucleus and affects the polar secretion of the cell wall modifying enzyme NODULE PECTATE LYASE (NPL). Our results integrate RPG into a core host machinery required to support symbiont accommodation, suggesting that its occurrence in plant host genomes is essential to co-opt a multimeric protein module committed to endosymbiosis to sustain IT-mediated bacterial infection.
Conserved allosteric inhibition mechanism in SLC1 transporters
Authors: Dong Yang , Wang Jiali , Garibsingh Rachel-Ann , Hutchinson Keino , Shi Yueyue , Eisenberg Gilad , Yu Xiaozhen , Schlessinger Avner , Grewer Christof
Published: March 2023

Excitatory amino acid transporter 1 (EAAT1) is a glutamate transporter belonging to the SLC1 family of solute carriers. It plays a key role in the regulation of the extracellular glutamate concentration in the mammalian brain. The structure of EAAT1 was determined in complex with UCPH-101, apotent, non-competitive inhibitor of EAAT1. Alanine serine cysteine transporter 2 (ASCT2) is a neutral amino acid transporter, which regulates pools of amino acids such as glutamine between intracellular and extracellular compartments . ASCT2 also belongs to the SLC1 family and shares 58% sequence similarity with EAAT1. However, allosteric modulation of ASCT2 via non-competitive inhibitors is unknown. Here, we explore the UCPH-101 inhibitory mechanisms of EAAT1 and ASCT2 by using rapid kinetic experiments. Our results show that UCPH-101 slows substrate translocation rather than substrate or Na+ binding, confirming a non-competitive inhibitory mechanism, but only partially inhibits wild-type ASCT2. Guided by computational modeling using ligand docking and molecular dynamics simulations, we selected two residues involved in UCPH-101/EAAT1 interaction, which were mutated in ASCT2 (F136Y, I237M, F136Y/I237M) in the corresponding positions. We show that in the F136Y/I237M double-mutant transporter, 100% of the inhibitory effect of UCPH-101 could be restored, and the apparent affinity was increased (Ki = 4.3 μM), much closer to the EAAT1 value of 0.6 μM. Finally, we identify a novel non-competitive ASCT2 inhibitor, through virtual screening and experimental testing against the allosteric site, further supporting its localization. Together, these data indicate that the mechanism of allosteric modulation is conserved between EAAT1 and ASCT2. Due to the difference in binding site residues between ASCT2 and EAAT1, these results raise the possibility that more potent, and potentially selective ASCT2 allosteric inhibitors can be designed .
Controlling periodic long-range signalling to drive a morphogenetic transition
Authors: Ford Hugh Z , Manhart Angelika , Chubb Jonathan R
Published: March 2023

Cells use signal relay to transmit information across tissue scales. However, the production of information carried by signal relay remains poorly characterised. To determine how the coding features of signal relay are generated, we used the classic system for long-range signalling: the periodic cAMP waves that drive Dictyostelium collective migration. Combining imaging and optogenetic perturbation of cell signalling states, we find that migration is triggered by an increase in wave frequency generated at the signalling centre. Wave frequency is regulated by cAMP wave circulation, which organises the long-range signal. To determine the mechanisms modulating wave circulation, we combined mathematical modelling, the general theory of excitable media, and mechanical perturbations to test competing models. Models in which cell density and spatial patterning modulate the wave frequency cannot explain the temporal evolution of signalling waves. Instead, our evidence leads to a model where wave circulation increases the ability for cells to relay the signal, causing further increase in the circulation rate. This positive feedback between cell state and signalling pattern regulates the long-range signal coding that drives morphogenesis.
Intensive care unit nurses’ knowledge, attitudes, perceptions of a safe environment, and compliance with the use of personal protective equipment: a descriptive observational study
Authors: Kim Eun Jin , Kim Hyunjung
Published: March 2023

Purpose: This study investigated the knowledge, attitudes, and perceptions of a safe environment, as well as self-reported and observed compliance with the use of personal protective equipment (PPE), among intensive care unit (ICU) nurses.Methods: This study was conducted in October 2021 with 55 nurses working in the medical and surgical ICUs of a general hospital in Seoul. A self-reported questionnaire and an observational tool for compliance with the use of PPE were used to collect data.Result: Except for masks, the observed compliance for all other PPE types was lower than the self-reported compliance. Male nurses showed significantly higher observed compliance than female nurses. Self-reported compliance with PPE use, including “when there is a possibility of contact with objects contaminated with blood or body fluids, mucous membranes, damaged skin, or contaminated skin” (r=.23, p=.015) and “when there is a possibility of contact with blood, body fluids, secretions, or exudates” (r=.27, p=.004) showed significant correlations with knowledge of PPE. In the results for self-reported compliance with PPE use, gown use had a significant correlation with knowledge (r=.24, p<.001) and perceptions of a safe environment (r=.15, p=.016) for PPE, and gloves showed significant correlations with attitudes (r=.14, p=.024) and perceptions of a safe environment (r=.18, p=.003).Conclusion: The observed compliance with PPE use tended to be lower than the self-reported compliance among ICU nurses. It is necessary to develop and apply an effective educational program that can enhance improve actual compliance with PPE use among intensive care unit nurses.
Usability and acceptance of crowd-based early warning of harmful algal blooms
Authors: Manik Lindung Parningotan , Albasri Hatim , Puspasari Reny , Yaman Aris , Al Hakim Shidiq , Siagian Al Hafiz Akbar Maulana , Kushadiani Siti Kania , Riyanto Slamet , Setiawan Foni Agus , Thesiana Lolita , Jabbar Meuthia Aula , Saville Ramadhona , Wada Masaaki
Published: March 2023

Crowdsensing has become an alternative solution to physical sensors and apparatuses. Utilizing citizen science communities is undoubtedly a much cheaper solution. However, similar to other participatory-based applications, the willingness of community members to be actively involved is paramount to the success of implementation. This research investigated factors that affect the continual use intention of a crowd-based early warning system (CBEWS) to mitigate harmful algal blooms (HABs). This study applied the partial least square-structural equation modeling (PLS-SEM) using an augmented technology acceptance model (TAM). In addition to the native TAM variables, such as perceived ease of use and usefulness as well as attitude, other factors, including awareness, social influence, and reward, were also studied. Furthermore, the usability factor was examined, specifically using the System Usability Scale (SUS) score as a determinant. Results showed that usability positively affected the perceived ease of use. Moreover, perceived usefulness and awareness influenced users’ attitudes toward using CBEWS. Meanwhile, the reward had no significant effects on continual use intention.
Irregularidades financeiras dos pareceres prévios do município do Rio de Janeiro à luz da teoria institucional
Authors: Da Silva Ted Jefferson Pereira , Sobreira Monica Cristina , De Moraes Melissa Christina Corrêa , Dos Santos Waldir Jorge Ladeira
Published: March 2023

Este artigo tem o objetivo principal de analisar os pareceres prévios das contas anuais do Prefeito do Município do Rio de Janeiro (RJ) emitidos pelo Tribunal de Contas do Município do Rio de Janeiro (TCMRJ) a fim de identificar as irregularidades financeiras recorrentes a luz da teoria institucional, bem como conhecer as congruências entre os relatórios e os principais assuntos debatidos na análise das contas desse município. Para tanto, ao dispor da Análise de Conteúdo, averiguou-se os relatórios de pareceres prévios, referentes ao exercício de 2013 a 2020. Trabalhou-se com 24 documentos extraídos da página Web do TCMRJ, sendo 8 pareceres prévios, 8 pareceres da Procuradoria Especial (PE) e 8 relatórios da Coordenadoria de Auditoria e Desenvolvimento (CAD, área técnica), tais documentos possuem 84 folhas em média, sendo os relatórios da área técnica o maior e dos pareceres prévios o menor, com, respectivamente, 221 e 12 páginas. Nos resultados, verificou-se que as principais irregularidades observadas pelo TCMRJ em seus Pareceres Prévios, no que tange ao período analisado, referem-se às despesas sem prévio empenho, às despesas previdenciárias e com seguridade, à Dívida Ativa, aos controles internos, regime de competência, transparência, registros contábeis incorretos e Fundeb.
Alimentação vegetariana e suas derivações: uma abordagem mercadológica sob o ponto de vista de quem consome
Authors: De Oliveira Júnior Manoel Carlos , Castro Ana Beatriz Falcunier , Oliveira Ana Claudia Maia , Oliveira Ingrid Abigail Cruz
Published: March 2023

A alimentação vegetariana e suas derivações conquistaram espaço no mercado, sendo reflexo de mudanças alimentares sustentadas em fatores culturais, de saúde e da questão do bem-estar animal em termos de condições precárias e exploração.  Este retrato se estende ao aumento da demanda de produtos vegetarianos no ambiente mercadológico. O presente artigo busca identificar a percepção dos consumidores classificados como vegetarianos, veganos e suas derivações acerca do mercado de alimentos desse nicho.  Para isso, fez-se aplicação de pesquisa quantitativa em meio virtual por meio da plataforma Google Forms, com respondentes residentes na cidade de Manaus, capital do Amazonas. A análise de resultados com as respostas obtidas e aporte de estatística descritiva demonstrou que motivados em sua maioria pela causa animal, hábitos saudáveis e meio ambiente, aqueles que se identificam com o critério de inclusão apontado observam a crescente disponibilidade e variedade de produtos não cárneos, ainda com preço pouco acessível e presença em praça de poucos estabelecimentos comerciais voltados a esse público, em contraste com o alto número de serviços delivery, sendo estes aspectos influenciados pela zona urbana em que os respondentes residem.
A Review on Bioanalytical Method Development and Validation for Estimation of Drugs by Using Hyphenated Techniques and its Applications on Routine Analysis
Authors: Jabeen Nameera , Haque M. Akiful
Published: March 2023

Bioanalytical methods are used to create a protocol that can identify and quantify bioactive molecules and their metabolites in human and animal samples. For determining the medication and its metabolites present in human/animal body, the bioanalytical method is efficient. One of the prominent bioanalytical roles is creating new techniques, validating existing processes, and analyzing samples. Most importantly, a compound can be calculated using many methods and can also be detected using various analytical methods. In specific biological samples, the drugs can be evaluated by different extraction procedures, such as solid-phase extraction, liquid extraction, protein precipitation etc.., All the steps in methods were investigated to know how environment, sample, or techniques influence the matrix assessment up to the study's time. The analytical methods, including high-pressure (HPLC), liquid chromatography combined with dual-mass spectroscopy (LCMS-MS), and Ultra-performance extraction (UPLC), can be used to obtain the in-depth analysis of medications. All have their strengths and weaknesses. Currently, bioanalysis is usually done by HPLC-MS and GCMS-MS. Linearity, repeatability, Accuracy, precision, selectivity, recovery and consistency are essential criteria. In this review we proposed to give importance of bioanalytical system production and validation parameters to aid in drug quality, purity, safety and efficacy.
Prevalence and Risk Factors of Polycystic Ovarian Syndrome PCOS: Cross-sectional Study
Authors: Mohmed Fawaz Eldirdiri Satti , Aljuhaysh Raghad Mubarak , Alonze Saad Khaleel , Alhagbani Mona Abdulrahman
Published: March 2023

Background: The most prevalent endocrine illness in women of reproductive age is polycystic ovarian disease. In this study, girls between the ages of 18 and 30 who were vesiting the maternity hospital refer in King Saud, Saudi Arabia, will be assessed for poly cystic ovaries prevalence and risk factors.

Methods: There were 1080 participants in this study, representing all outpatient visits over the chosen period (Jul 2022 to Jan 2023). They were required to answer questions about their menstrual cycle and the symptoms of hyperandrogenism on a questionnaire. Weight, height, waist, and hip circumferences were measured anthropometrically. Blood pressure was measured. A girl who exhibits either hirsutism or irregular menstruation, or both, was considered a probable case. All of the likely instances were required to undergo thorough examinations, hormone estimations, and ovarian ultrasounds.

Results: Among the 1080 girls, 191 (17.6%) had irregular menstrual cycles, and 75 (6.9%) had hirsutism. According to Rotterdam's criteria, the prevalence of polycystic ovaries was found to be 18.9% after hormonal testing and ultrasound. The non-vegetarian diet, socioeconomic level I and II, snacking, obesity, insufficient physical activity, prehypertension, hypertension, central obesity, and self-reported emotional health issues in girls, and poly cystic ovaries in the family, were found to be substantially linked with polycystic ovaries.

Conclusion: To lessen poly cystic ovaries and associated problems in females, early lifestyle change and health education were necessary.
Three metal-work hoards of the Roman period from southern Scotland
Authors: Piggott Stuart , Burgess E Martin , Henshall Audrey
Published: March 2023

A re-examination of three Roman hoards that were originally analysed by James Curle in the 1930’s. It is noted that although each hoard contains both Roman and native items, the majority of the finds are related to farming and not warfare. The article concludes with a catalogue of all the finds from each hoard and comparative analysis with similar finds.
Large Study Finds Women Are (Still) Much More Likely to Die or Have Complications After Coronary Artery Bypass Graft Surgery Than Men
Authors: Ruder Kate
Published: March 2023

This Medical News article discusses a new study in JAMA Surgery about outcome differences between women and men after the most common surgical treatment for coronary artery disease.
Overall and Racial and Ethnic Subgroup Prevalences of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis
Authors: Sy Nene , Mastacouris Nicole , Strunk Andrew , Garg Amit
Published: March 2023

Importance

Prevalences of alopecia areata (AA), alopecia totalis (AT), and alopecia universalis (AU) are poorly established.

Objective

To estimate overall and subgroup prevalences of AA and its subtypes.

Design, Setting, and Participants

This cross-sectional study using electronic records comprising the Explorys database (Watson Health, IBM Corporation) included children, adolescents, and adults seeking healthcare across the 4 census regions in the US between January 1, 2019, and December 31, 2019. The statistical analysis was conducted between July 21, 2022, and December 22, 2022.

Main Outcomes and Measures

Prevalent cases of AA, AT, and AU.

Results

Of the 1 093 176 patients who met inclusion criteria, 1812 had at least 1 code for AA, 1216 female (67%) and 596 male (33%) patients. Overall age-and-sex standardized prevalences among adults and among children and adolescents were observed to be 0.18% and 0.10%, respectively. The age-standardized prevalence ratio in women to men was 1.32. Standardized prevalence was highest in those aged 30 to 39 (297 per 100 000; 95% CI, 263-335) and 40 to 49 (270 per 100 000; 95% CI, 240-303) years. The highest standardized prevalence was observed among Asian patients (414 per 100 000; 95% CI, 306-548), followed by patients reporting another race or multiple races (314 per 100 000; 95% CI, 266-368), Black (226 per 100 000; 95% CI, 199-255), and Hispanic/Latino (212 per 100 000; 95% CI, 129-328) patients. White patients had the lowest standardized prevalence (168 per 100 000; 95% CI, 157-179) among racial and ethnic subgroups. Relative to White patients, standardized prevalence ratios for Asian, Black, and Hispanic/Latino patients were 2.47 (95% CI, 2.17-2.81), 1.35 (95% CI, 1.26-1.44), and 1.26 (95% CI, 1.03-1.55), respectively. Cases of AT and AU comprised approximately 9% of patients diagnosed with AA.

Conclusions and Relevance

The findings of this cross-sectional study suggest that there is a significant burden of AA, AT, and AU in the US in which people of color, particularly Asian Americans, appear to be disproportionately affected.
Financial Impact of Metabolic Surgery on Prescription Diabetes Medications in Michigan
Authors: Varban Oliver A. , Hassett Kristen P. , Yost Monica , Carlin Arthur M. , Ghaferi Amir A. , Finks Jonathan F. , Ehlers Anne P.
Published: March 2023

This study compares expenditures for diabetes medications before and after metabolic surgery among patients with diabetes in Michigan.
Long noncoding RNAs are substrates for cytoplasmic capping enzyme
Authors: Mukherjee Avik , Islam Safirul , Kieser Rachel E. , Kiss Daniel L. , Mukherjee Chandrama
Published: March 2023

Cytoplasmic capping returns a cap to specific mRNAs, thus protecting uncapped RNAs from decay. Prior to the identification of cytoplasmic capping, uncapped mRNAs were thought to be degraded. Here, we test whether long noncoding RNAs (lncRNAs) are substrates of the cytoplasmic capping enzyme (cCE). The subcellular localisation of 14 lncRNAs associated with sarcomas were examined in U2OS osteosarcoma cells. We used 5′ rapid amplification of cDNA ends (RACE) to assay uncapped forms of these lncRNAs. Inhibiting cytoplasmic capping elevated uncapped forms of selected lncRNAs indicating a plausible role of cCE in targeting them. Analysis of published cap analysis of gene expression (CAGE) data shows increased prevalence of certain 5’‐RACE cloned sequences, suggesting that these uncapped lncRNAs are targets of cytoplasmic capping.
Backlot Suburbia: A California Story
Authors: Hodgetts Craig
Published: March 2023

The story of California – the influence of its émigré architects during the 20th century and its important position in developing the ‘cool’ mid‐century modernism that was to become so fashionable around the globe – cannot be underestimated. Craig Hodgetts, architect and academic, and founding half of architectural practice Hodgetts+Fung, looks back at those heady days and the evolution of Los Angeles as an architectural mecca.
The Picture and the Frame: Understanding a Contested Landscape
Authors: Tada Grace Mitchell
Published: March 2023

The Californian terrain is formed of many ‘contested landscapes’ – by different communities, the advantaged and the disadvantaged. San Francisco‐based writer Grace Mitchell Tada describes the work of architect, artist, designer and educator Walter Hood and his studio's forays into these difficult areas.
A Hands‐on Conceptual Rigour: A Multi‐scalar Approach
Authors: Spiller Neil
Published: March 2023

AD Editor Neil Spiller first met Dwayne Oyler and Jenny Wu, founders of the Oyler Wu Collaborative, in 2014. Since then he has been interested in their practice, buildings and teaching, and their application of multi‐scalar solutions to projects from jewellery to urban towers, memorials and stairways. Here he talks to them about their recent designs, and the ambience and competitive nature of practising in Los Angeles.
Reconstruction of Low Dimensional Electronic States by Altering the Chemical Arrangement at the SrTiO3 Surface
Authors: Li Hang , Brito Walber H. , Guedes Eduardo B. , Chikina Alla , Dahm Rasmus T. , Christensen Dennis V. , Yun Shinhee , Chiabrera Francesco M. , Plumb Nicholas C. , Shi Ming , Pryds Nini , Radovic Milan
Published: March 2023

Developing reliable methods for modulating the electronic structure of the 2D electron gas (2DEG) in SrTiO3 is crucial for utilizing its full potential and inducing novel properties. Herein, it is shown that relatively simple surface preparation reconstructs the 2DEG at the SrTiO3 (STO) surface, leading to a Lifshitz‐like transition. Combining experimental methods, such as angle‐resolved photoemission spectroscopy (ARPES) and X‐ray photoemission spectroscopy with ab initio calculations, that the modulation of the surface band structures can be effectively achieved via transforming the chemical composition at the atomic scale is found. In addition, ARPES experiments demonstrate that vacuum ultraviolet light can be efficiently employed to alter the band renormalization of the 2DEG system and control the electron‐phonon interaction . This study provides a robust and straightforward route to stabilize and tune the low‐dimensional electronic structure via the chemical degeneracy of the STO surface.
Fabrication of TiO2/MXene Nanohybrid Electron Transport Layer by Artist Spray Gun Assisted Pyrolysis Method for Efficient Carbon Perovskite Solar Cell
Authors: Panneerselvam Pratheep , Ramasamy Senthilkumar , Rajendra Saradh Prasad , AlSalhi Mohamad S. , Guo JohnZhanhu , Angaiah Subramania
Published: March 2023

A new class of 2D Ti3C2Tx (MXene) in different weight percentages (0, 1, and 2 wt.%) are hybrid with TiO2 nanopowder to form TiO2/MXene nanohybrids by artist spray gun assisted (ASG) pyrolysis method to use an electron transport layer (ETL) for carbon perovskite solar cell (PSC). The influence of Ti3C2Tx on TiO2 in light absorption, charge separation and carrier dynamics is studied in detail. The formation of TiO2/MXene is studied by X‐ray diffraction analysis. The emission spectrum, charge separation and carrier dynamics of TiO2/MXene nanohybrid are analyzed by photoluminescence studies. They exhibit an emission spectrum at 390 nm. The photoluminescence and electrochemical impedance results reveal that the Ti3C2Tx nanosheets provide a superior charge transfer path with less electron transfer resistance at the ETL/perovskite interface, which lead to produce higher photocurrent. This study reveals that TiO2/MXene nanohybrid can be used as a promising ETL to enhance the photo‐conversion efficiency of carbon PSC. These results reveal that TiO2‐ MXene (1 wt.%) nanohybrid ETL shows the highest PCE of 5.15% than that of TiO2‐ MXene (2 wt.%) nanohybrid ETL and pristine TiO2 ETL‐based PSC (4.64%).
Synthesis of Aryl Thiocyanates and Aryl Selenocyanates via Visible‐Light Activation of Arylazo Sulfones
Authors: Gao Yu , Sparascio Sara , Terlizzi Lorenzo Di , Serra Massimo , Yue Guanglu , Lu Yaru , Fagnoni Maurizio , Zhao Xia , Protti Stefano
Published: March 2023

Two visible‐light mediated protocols (based on a copper photoredox catalyzed and on a photochemical reaction, respectively) for the preparation of aryl thiocyanates and aryl selenocyanates from arylazo sulfones are presented herein, by exploiting the peculiar photoreactivity and redox activity of such substrates. The developed reactions take place in good to satisfactory yields and with a large scope.

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Inverse Vulcanized Polymers for Sustainable Metal Remediation
Authors: Müller Federico G. , Lisboa Lynn S. , Chalker Justin M.
Published: March 2023

Heavy metal exposure has an enormous burden on human health. Current metal removal technologies require substantial improvements in relation to their efficiency and environmental impact if this issue is to be addressed. Over the last decade, several new types of sulfur‐rich sorbents have been investigated. These polymers typically have high removal efficiencies for toxic metals such as mercury and are often made using sustainable and low‐cost reagents. This review surveys polymers made by inverse vulcanization that have been tested for metal capture. Focus is put on environmental impact, feedstock for sorbent synthesis, selectivity towards metal removal, toxicity studies, and the reusability of the polymers. Furthermore, this review discusses current limitations and the potential opportunities to use different comonomers for improved metal capture.
Experimental and Theoretical Studies of the Surface Oxidation Process of Rare‐Earth Tritellurides
Authors: Kopaczek Jan , Yumigeta Kentaro , Ibrahim Akram , Sayyad Mohammed Y. , Sinha Shantanu , Sailus Renee , Hays Patrick , Moosavy Seyed Tohid Rajaei , Susarla Sandhya , Ataca Can , Kudrawiec Robert , Tongay Sefaattin
Published: March 2023

Recent studies have established Van der Waals (vdW) layered and 2D rare‐earth tritellurides (RTe3) as superconductors and near room‐temperature charge density wave (CDW) materials. Their environmental stability raises natural concern owing to aging/stability effects observed in other tellurium‐based layered crystals. Here, the results establish the stability and environmental aging characteristics of these RTe3 systems involving a variety of metals such as La, Nd, Sm, Gd, Dy, and Ho. The atomic force microscopy (AFM) and scanning electron microscopy (SEM) results show that all the RTe3 sheets oxidize to form thin TeOx layers that are primarily confined to the surface, edges, and grain boundaries. Time‐resolved in situ Raman spectroscopy measurements are used to understand the kinetics of the oxidization process for different lanthanide metal cations and establish their relative stability/resilience to oxidization. Overall results indicate that the vdW layers show higher air stability as the 4f electron number decreases going from Ho to La, resulting in the most stable LaTe3 compared to the least stable HoTe3. Comprehensive quantum mechanical simulations reveal that environmental degradation originates from a strong oxidizing reaction with O2 molecules, while humidity (H2O) plays a negligible role unless Te vacancies are present. Moreover, the simulations explain the effects of 4f electrons on the work function and Te vacancies formation, which directly impact the aging characteristics of RTe3 layers. Interestingly, optical and electrical measurements show that the CDW response is still observed in aged RTe3 layers owing to the presence of underlying pristine/nonoxidized RTe3 layers, except CDW transition temperatures increase due to the thickness effect. Overall results offer the first in‐depth environmental aging studies on these materials, which can be applied to engineer and design their chemical stability, surface properties, and overall CDW characteristics.
Resilience of maize, wheat, and soybean cropping systems as affected by fertilization: Analysis of a long‐term field network
Authors: Manenti Luis , Macholdt Janna , Garcia Fernando O. , Rubio Gerardo
Published: March 2023

Elucidating how different fertilization treatments affect the resilience of farming systems and the environmental adaptability of agricultural crops is relevant to assess their efficacy as a strategy for minimizing yield fluctuations and supporting global food security. The aim of this work was to compare the effects of fertilization practices and to distinguish the effect of macronutrients on the resilience of maize, wheat, and soybean cropping systems. A long‐term experiment involving the three crops and five fertilization treatments (control without fertilization, nitrogen and sulphur fertilization, phosphorus and sulfur fertilization, nitrogen and phosphorus fertilization, nitrogen, phosphorus and sulfur fertilization) was conducted for 19 years in the Pampean region (Argentina) that includes five study sites. The four combinations of nutrient additions increased crop yields in unfavorable environments, which indicates that even in adverse years, fertilization was a valid tool to sustain yield performance. The Finlay and Wilkinson regression slopes in maize and full‐season soybean did not differ between fertilization treatments, which suggests that fertilization did not change crop adaptation to the environment and that the observed positive effect of fertilization in unfavorable environments was maintained along the environmental gradient. In contrast, wheat and double‐cropped soybean were able to capitalize on the environmental conditions of favorable years, as shown by the progressive increases in yields as the environment became more favorable. Maize had the highest response to nitrogen, whereas wheat and double‐cropped soybean exhibited the highest responses to phosphorus and sulfur, respectively. Our findings are useful to extract guidelines that may lead to greater resilience through fertilization management practices.
The impact of receiving polygenic risk scores for alcohol use disorder on psychological distress, risk perception, and intentions to reduce drinking
Authors: Driver Morgan N. , Kuo Sally I‐Chun , Dron Jacqueline S. , Austin Jehannine , Dick Danielle M.
Published: March 2023

For the return of polygenic risk scores to become an acceptable clinical practice in psychiatry, receipt of polygenic risk scores must be associated with minimal harm and changes in behavior that decrease one's risk for developing a psychiatric outcome. Data from a randomized controlled trial was used to assess the impact of different levels of hypothetical polygenic risk scores for alcohol use disorder on psychological distress, risk perception, and intentions to change drinking behaviors. The analytic sample consisted of 325 participants recruited from an urban, public university. Results demonstrated that there were significant increases in psychological distress as the level of genetic risk for alcohol use disorder increased. In addition, the perceived chance of developing alcohol use disorder significantly increased as the level of genetic risk increased. Promisingly, a greater proportion of participants indicated that they would intend to engage in follow‐up behaviors, such as seeking additional information, talking to a healthcare provider about risk, and reducing drinking behaviors, as the level of genetic risk increased. Returning polygenic risk scores for alcohol use disorder in a clinical setting has the potential to promote risk‐reducing behavior change, especially with increasing levels of genetic risk. The study was registered on ClinicalTrials.gov (Identifier: NCT05143073).