bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract P480: Digesting Detention: Investigating Eating Patterns in Jails
Authors: Schmitter Elizabeth , Camplain Ricky L , Teufel-Shone Nicolette , Shuman Sara J , Lopez Javier
Published: May 2024

Background:
Over 12 million people cycle through jails every year in the US. People incarcerated experience significant health inequities compared to the general population, including higher rates of hypertension, diabetes, and cardiovascular disease. Despite widespread acceptance of the association between diet and cardiovascular-related outcomes, research documenting dietary intake and nutritional status of individuals incarcerated in jail is limited. Food intake is notoriously difficult to measure, and current measurement tools are not designed for the jail setting.

Objectives and Hypotheses:
The objectives of this study were to 1) develop a food intake questionnaire for incarcerated adults; 2) document participants’ perceived accuracy of the instrument and 3) compare calorie, macronutrient, and micronutrient intake of people incarcerated in jail to the Acceptable Macronutrient Distribution Range (AMDR) and the 2020-2025 Dietary Guidelines for Americans (DGA). We hypothesized that participants would consume more sodium, added sugar, and saturated fat while incarcerated compared to the DGA and macronutrient consumption patterns of people incarcerated in jail would not meet the AMDR.

Methods:
Cycle menus were obtained from the jail administration to design a questionnaire that would allow study participants to accurately document the consumption of foods provided by the jail and purchased through commissary each day. Sixty-five (65) incarcerated adults (24 women and 41 men) were recruited from a northern Arizona county jail to complete the 4-day cross-sectional food intake questionnaire. Participants were asked to fill out the questionnaires in real time. Following the study period, questionnaires were collected, and participants provided feedback on the appropriateness and feasibility of the questionnaire via a group listening session. Daily total and mean calorie, macro- and micronutrient intake were calculated using the ASA24 and compared to the AMDR and the DGA.

Results:
Of 65 people recruited, 64 completed the questionnaire. Participants reported enjoying reflecting on their diets but indicated that institutional menu modifications during the study period led to confusion as the food items listed did not always match what was served. Average percent saturated fat of total calories (11.7%, 95% CI: 10.9, 12.4) and sodium (3723 mg, 95% CI: 3048, 4399) exceeded DGA recommendations. Macronutrient consumption was within recommended ranges.

Conclusions:
The results of this study can inform efforts to improve the food intake tracking tool which can be used in future research assessing nutritional status in jails and prisons, as well as other controlled food environments. These results will also provide the first observational evidence of nutritional status in jail settings, informing future institutional policy change and interventions.
Abstract P488: Diet Significantly Alters Metabolic Gene Expression Associated With Probiotic Administration in Mice
Authors: Westlake Jonathan , Kagel Brian , Lichti Nathan , Singh Shreya , Houghton Jeffrey , Gigliotti Joseph
Published: May 2024

The microbial flora in the gastrointestinal tract is known to be mediated by diet and is thus one potential mechanism by which diet influences health. Furthermore, probiotic supplementation also affects various biological markers, however it is unclear if a diet and probiotic interaction exists. Therefore, the goal of our study was to assess how diet and probiotic administration influenced metabolic health in mice. Weanling, male C57Bl/6 mice were randomly assigned to receive one of three diets: chow, American Institute of Nutrition 93 formulation (AIN93), or our novel Americanized diet (AD) formulated to match the 50
th
percentile of nutrient intake in Americans. Mice were then administered a commercially-available probiotic for 2-weeks and then euthanized. Insulin sensitivity was determined by performing an insulin-tolerance test (ITT) in a separate cohort. Blood was collected for serum analysis of circulating metabolic markers. Liver and adipose tissue were collected and processed to quantify the mRNA expression of key metabolic genes by real-time RT-PCR. All data were analyzed using General Linear Model Procedures in SPSS with significance determined at P<0.05. Diet (P=0.001), but not probiotic supplementation (P=0.27), significantly affected ITT with the AD group having the lowest responsiveness to insulin (
P
≤0.001). Chow fed mice tended (
P
=0.09) to have lower HDL than the AIN-93 and AD fed mice. Probiotic administration alone resulted in an upregulation of liver mRNA expression of SREBF2, particularly the AIN-93 diet group (P=0.024). Probiotic supplementation also modulated liver transcription of NF-κB1 with an increase in chow-fed mice, but decreased in those fed AD (P=0.016). Increased transcription of the key carbohydrate metabolism regulating gene,
Mlxipl
, was found to occur in liver of the chow and AIN-93 and also tended to differ in mice fed the AD (P=0.06). In the adipose tissue, diet (P<0.001), probiotic (P<0.001), and their interaction (P=0.01) influenced transcription of the androgen receptor (
Ar
) gene. The chow group had the most
Ar
transcription, while the AD had the lowest transcription in both the diet alone and probiotic treated group. Taken together, our data highlight the significance of diet in mediating the beneficial metabolic effects of probiotic administration. Diet appears to play a greater role in dictating the expression of key metabolic enzymes and transcription factors and future studies are needed to validate these findings and determine their physiological significance.
Abstract P512: Associations of Serum Insulin-Like Growth Factor (IGF)-1 Levels With Cognitive Function and Atherosclerosis in a Japanese General Population: The Tanushimaru Study
Authors: Nohara-Shitama Yume , Yoshimura Harumi , Nagisa Morikawa , Fukami Ako , Enomoto Mika , Adachi Hisashi , Fukumoto Yoshihiro
Published: May 2024

Background:
Insulin-like growth factor (IGF)-1 is a peptide hormone implicated in insulin sensitivity and anti-inflammatory. However, there is limited exploration of the association of serum IGF-1 levels with cognitive function and atherosclerosis. This study aimed to investigate the association between serum IGF-1 levels and cognitive function, as well as carotid atherosclerosis in a general population.

Methods:
In 1,345 participants (544 men; mean age, 68.7 (11.3) years) recruited from the Tanushimaru cohort, we measured their serum IGF-1 levels and evaluated cognitive function using mini-mental state examination (MMSE) and atherosclerosis through carotid intima-media thickness (IMT). Linear regression models were utilized to analyze the association between quartiles of serum IGF-1 levels and MMSE scores, as well as IMT, continuous dependent variables. We also visualized the continuous associations using restricted cubic spline models. Two-sided statistical significance was defined as
p
<0.05. All statistical analyses were performed using the SAS system (Release 9.4, SAS Institute, Cary, NC, USA).

Results:
The mean serum IGF-1 level was 96.6 (30.2) ng/ml. Multiple linear regression analysis revealed that the highest quartile of serum IGF-1 levels showed a statistically significant association with higher MMSE scores (p=0.0019), and the third quartile also reached statistical significance (p=0.0006) compared to the lowest. We observed a positive association between serum IGF-1 levels and MMSE scores, even when exploring the full spectrum of serum IGF-1 levels with their spline terms (Figure). In contrast, serum IGF-1 levels did not exhibit a significant association with IMT measurements.

Conclusion:
High serum IGF-1 levels were associated with higher cognitive function, while no significant association was observed with carotid atherosclerosis. Our findings suggest that IGF-1 levels may play a role in preserving cognitive function, potentially distinct from its role in atherosclerosis.
A synopsis of the Tanaidacea (Crustacea: Peracarida) of Singapore, with a review of tanaidacean diversity in Southeast Asia and the South China Sea
Authors: KONG CHIM CHEE
Published: May 2024

In the first comprehensive taxonomic study of the tanaidacean fauna of Singapore, a total of 23 species belonging to two suborders, three superfamilies, 13 families and 22 genera were identified from approximately 2,400 specimens, including 11 species that are possibly new to science. This material was collected from various localities in Singapore waters, from the intertidal zone to subtidal habitats up to 91 m in depth. Many species exhibited a narrow bathymetric distribution and strong affiliation to certain habitats or microhabitats such as mudflats, coral reefs, and barnacle shells on rocky shores. The Singapore Strait yielded 20 tanaidacean species, almost thrice the number of species (7) present in the Johor Straits. Three species were confined to the brackish waters in the inner parts of the Johor Straits and Sungei Pandan. Furthermore, a total of 153 tanaidacean species has now been recorded from Southeast Asia and the South China Sea. The presence of the family Numbakullidae in this region is also documented for the first time.
Design of a Hybrid Meta-Heuristic Optimizer for Modelling a Multi-Level Inverter
Authors: Bharath Choudry V. , Kavithamani A.
Published: May 2024

Meta-heuristic (MH) algorithms have significantly impacted optimization in several technical domains. These algorithms must be implemented in hardware for several technical applications. Hence their performance is essential. Multilayer inverter failure detection is widely applied in
High Voltage DC (HVDC) conduction and Industrialized Drives. It uses various meta-heuristic techniques and a NN (Neural Network) as the DM (Decision-Making) mechanism. After the network has been trained for various failure scenarios in the multilevel inverter, the weight and bias parameters
are optimized using a MH optimizer to compare the model’s performance. The output of a Multilevel Inverter (ML9LI) supplied by the system is approximated and inferred using a MATLAB-based approach. Features gained from the multi-level inverter, such as positive, negative, and zero sequence
voltage and the THD of the output voltage, boost the FD (Fault Detection) ability when using a renewable energy-based power generation system as the basis for the inverter. Particle Swarm Optimization (PSO) and Firefly optimization (FO) are hybridized to form Multi-level Inverter (MLI)-based
optimization methods are employed.
An Efficient Lightweight Crypto Security Module for Protecting Data Transmission Through IOT Based Electronic Sensors
Authors: Olayah Fekry , Yami Mohammed Al , Abosaq Hamad Ali , Abdelrahman Ali Yahya Ali , Siddiqui Md. Ashraf , Irshad Reyazur Rashid , Shahwar Samreen , Islam Asharul , Sultana Rafia
Published: May 2024

The Internet of Things (IoT) devices are advanced nanoelectronics devices which has recently witnessed an explosive expansion in the field of communication and electronics, becoming ubiquitous in various applications. However, the rapid growth of IoT applications makes them prone to
security threats and data breaches. Hence, cryptographic techniques are developed to ensure data confidentiality and integrity in IoT and many of the applications from optoelectronics. However, the existing cryptographic algorithms face challenges in securing the data from threats during transmission,
as they lack effective key management. Therefore, we proposed a novel optimized lightweight cryptography (LWC) to resolve this challenge using the combined benefits of Grey Wolf Optimization and Hyper Elliptic Curve Cryptography (GW-HECC). The proposed LWC algorithm protects the data from
attacks during data exchange by optimizing the key management process and aims to deliver greater Quality of Service (QoS) in IoT networks. An IoT network was initially created with multiple sensor devices, IoT gateways, and data aggregators. The proposed framework includes a Quantum Neural
Network (QNN)-based attack prediction module to predict the malicious data entry in the IoT network. The QNN learns the attack patterns from the historical IoT data and prevents incoming malicious data entries, ensuring that only normal data is transmitted to the cloud. For secure data transmission,
the sensed data from the IoT network are encrypted using the proposed GW-HECC. The presented work was designed and implemented in Python software; the experimental results demonstrate that the proposed method offers greater data confidentiality of 97.9%, improved attack prediction accuracy
of 99.8%, and a reduced delay of 0.37 s. Furthermore, a comparative analysis was made with existing cryptographic algorithms, manifesting that the proposed algorithm acquired improved results.
Design and Analysis of High Performance FinFET-Based Linear Feedback Shift Register for Cryptography Applications
Authors: Susaritha M. , Senthilkumar J.
Published: May 2024

Nowadays, all the elements of our surrounding is occupied by electronics. Electronics occupies major role on our day today life. Electronics device integration on a single chip enhances performance in terms of speed, low-power circuits, and area. Integration of VLSI provides better
scalability and reliability. This research paper focused on the implementation of Linear feedback shift registers (LFSR) using FinFET techniques at the layout level for various applications, including cryptography. FinFETs are highlighted as a replacement for CMOS technology, offering advantages
such as improved performance in terms of speed, low-power circuits, and area. Linear feedback shift registers are commonly used in digital systems and cryptography for generating pseudo-random sequences. The use of FinFET technology in the layout level suggests an interest in exploring advanced
semiconductor technologies to enhance the performance of these circuits. The paper appears to cover different design methods of LFSRs, which could include aspects like circuit optimization, power efficiency, and reliability. The integration of electronics on a single chip, particularly with
FinFET technology, is noted for its potential to provide better scalability and reliability. The first architecture is created using bulk CMOS techniques; whereas the second is constructed using two fin FinFET LFSRs. Using the Microwind designing tool, the third technique is developed with
a 3-fin FinFET LFSR. It provides a solution for a novel FinFET architecture that implements LFSR. When comparing CMOS and FinFET circuit designs for LFSR, the latter achieves superior performance in terms of area and power efficiency. An analysis is conducted on the design techniques and performance
of CMOS LFSR, 2 fin FinFET based LFSR, and 3 fin FinFET. According to the experimental findings, the CMOS-based LFSR uses 1.243 mW of power; the FinFET-based LFSR uses 90.47 μW, and the two fin FinFET LFRS uses 0.254 mW.
Novice School Leaders’ Turnover Intentions: The Role of Working Conditions and Organizational Factors
Authors: Richard Tobias
Published: May 2024

Purpose: This study aimed to explore the relationship between the psycho-social working conditions of novice school leaders and their turnover intentions, focusing on potential variations across public- and private schools and school levels. Research Methods: We invited all novice school leaders (n = 3,389) enrolled in the in-service Swedish Principal Training Program to participate in an extensive survey, with a 65% (n = 1,998) response rate. The survey investigated turnover intentions, working conditions, prerequisites, and organizational ambiguity. The collected survey data, in combination with official data, were analyzed using ANOVA's to identify differences across actors and school levels, and linear regressions to investigate factors explaining turnover intentions. Findings: The findings revealed higher turnover intentions among public school leaders compared to private school leaders. This was attributed to differences in prerequisites and organizational ambiguity. All novice school leaders exhibited similar patterns regarding factors strongly associated with turnover intention, despite actor and school level affiliation. Specific levels of demand, autonomy, and support combined, predicted turnover intentions among novice school leaders with notable accuracy. Implications for Research and Practice: The study has profound implications for stakeholders in the educational system striving to decrease novice school leader turnover. Providing adequate working conditions emerges as a key factor for nurturing and retaining school leaders from the novice pool, offering insights into strategies for managing leadership transition in schools.
Financial Development and Subnational Export Performance: Evidence from the Indian States
Authors: Arora Puneet Kumar , Mukherjee Jaydeep
Published: May 2024

The present study investigates the relationship between export performance and the level of financial development for 30 Indian states and union territories (UTs) from 2011–12 to 2020–21. The study first ranks the states and UTs on the parameters of financial development and physical infrastructure using the robust principal component analysis method. By applying the instrumental variable fixed effects panel data technique, the study observes that the level of financial development has a significant positive impact on the export performance of the states. The study also finds a positive effect of the availability of physical infrastructure, quality of governance and fiscal position on states’ export performance but does not observe a significant role of political stability in this context. The results suggest that export growth in the economically laggard and Himalayan states can come through policy interventions to improve financial development. In contrast, landlocked states need better physical infrastructure to facilitate easier production and transportation of export goods. The study lends new perspectives to the nascent literature on inter-regional disparities in India’s export performance and is expected to provide insights into improving the sub-national export performance of other developing countries as well.

JEL Codes: F14, F36, F4
A Spectrum of Autonomy: Towards a Theoretical Framework of Strategic Autonomy
Authors: Vu Hoang Le Thai , Ngo Lan Di , Nguyen Thanh Tien
Published: May 2024

Despite the renewed significance and popularity of strategic autonomy in recent years, this term remains undertheorized. Current usage of the term makes it difficult to determine whether an actor is strategically autonomous or not, and whether a particular course of action enhances autonomy or decreases it. This article thus begins by tracing the intellectual history of strategic autonomy, and then by evaluating the way in which modern scholars use this term. Consequently, it advances a novel conceptualization of the term, arguing that instead of being a binary concept, strategic autonomy represents the highest level of autonomy on a full spectrum of autonomy. While providing a comprehensive theory of strategic autonomy is beyond the scope of this article, we offer some preliminary hypotheses on why the international system incentivizes actors to pursue strategic autonomy.
A Claim of Conscience: The Duty to Prove Oneself a Resistor
Authors: Pakaluk Michael , Pakaluk Catherine R.
Published: May 2024

An important question that arises as regards a member in a gravely unjust system is whether by any act of “resistance,” undertaken at personal risk, he proved himself to be set against that system. This was the question posed by de-Nazification experts employed by the U.S. military in occupied Germany after World War II.1 A similar question is posed today by social movements, such as Black Lives Matter, reacting against historical racism in the United States. We argue that, today, those who in conscience, as members of a gravely unjust system, have wanted to reject vaccinations developed or tested using cell lines derived from abortion, should be understood and evaluated in the same way. We believe that such an approach provides perhaps the best hope for the re-invigoration of society through the pro-life ideals embodied in the “gospel of life.”
Attitudes of cardiac rehabilitation and stroke teams towards integration of stroke survivors into adapted cardiac rehabilitation: A focus group study
Authors: Clague-Baker Nicola , Robinson Thompson , Hagenberg Annegret , Drewry Sophie , Singh Sally
Published: May 2024

Objective

To explore the attitudes and beliefs of cardiac rehabilitation and stroke teams towards adapted cardiac rehabilitation, and the broader topics of exercise, healthy lifestyles and health behaviour change, for people with mild-to-moderate severity stroke in the sub-acute phase of recovery.

Design

Qualitative focus group-based study.

Setting

Acute and community national health service trusts.

Participants

Stroke and cardiac rehabilitation team members.

Intervention

Adapted cardiac rehabilitation.

Main measures

Focus groups. Thematic analysis was applied to the transcribed data.

Results

Overall, 57 health professionals participated in 12 focus groups. Positive impacts for teams and stroke survivors were identified particularly confidence. However, there were negatives, barriers and adaptations identified. In addition, there was a lack of knowledge for cardiac rehabilitation teams in relation to stroke survivors and stroke teams in relation to cardiac rehabilitation, exercise and healthy lifestyles.

Conclusions

Cardiac rehabilitation and stroke staff attitudes to cardiac rehabilitation for stroke survivors showed a range of benefits, negatives, barriers and adaptations needed. Confidence and knowledge of the cardiac rehabilitation and stroke teams needs to be addressed.

Registration

ISRCTN65957980.
Association between electroencephalogram alpha-band oscillations and executive and processing functions in patients with cerebral small vessel diseases
Authors: Zhao Mengxi , Hu Guoliang , Lu Yao , Yang Qianqian , Chen Xun , Wang David , Collet Jean-Paul , Wang Yilong , Guan Ling
Published: May 2024

Electroencephalogram (EEG) alpha-band oscillations may reflect executive and processing function in patients with cerebral small vessel disease (CSVD). We aimed to assess such association and its relationship with CSVD severity, and to identify specific alpha-band parameters and the cut-off values for cognitive screening. We analysed the dispersion of amplitude-frequency characteristics of EEG alpha-band and different alpha-band parameters (PFα , ΔPFα , PPα , NCL) in different brain locations. We also assessed patients’ executive and processing functions using verbal fluency test (VFT) and color trails test (CTT), and CSVD severity using total burden and Fazekas scores. 129 patients were recruited in the study. After adjusting for age, gender and education, PFα(F3), PFα(F4) and NCL were significantly associated with VFT-composite performance ( p < 0.05). CTT-1 time and error were associated with PFα(F3), PFα(F4), ΔPFα(O1;F3) and CSVD severity ( p < 0.05), whereas CTT-2 time was only associated with CSVD severity. Moreover, the correlations between alpha-band oscillations and cognitive function were higher in low than in high disease-severity group (ρ: −0.58 vs. −0.38, p < 0.05). The AUC of selected alpha-band parameters were higher than 0.8 for VFT and CTT. Specific alpha-band parameters in the frontal lobe were identified to correspond to executive and processing function. Assessing EEG alpha-band oscillations may assist in screening cognitive impairment.
Successful allogeneic fecal microbiota transplantation for severe diversion colitis: a case report
Authors: Cheng Chuan-Li , Wang Xiao-Jing , Fan Li-Xin , Lv Yong-Ling , Xiong Kai , Jiang Zhi-Wei , Gan Tian , Fu Guang
Published: May 2024

Ileostomy diverts the flow of feces, which can result in malnutrition in the distal part of the intestine. The diversity of the gut microbiota consequently decreases, ultimately leading to intestinal dysbiosis and dysfunction. This condition can readily result in diversion colitis (DC). Potential treatment strategies include interventions targeting the gut microbiota. In this case study, we effectively treated a patient with severe DC by ileostomy and allogeneic fecal microbiota transplantation (FMT). A 69-year-old man presented with a perforated malignant tumor in the descending colon and an iliac abscess. He underwent laparoscopic radical sigmoid colon tumor resection and prophylactic ileostomy. Follow-up colonoscopy 3 months postoperatively revealed diffuse intestinal mucosal congestion and edema along with granular inflammatory follicular hyperplasia, leading to a diagnosis of severe DC. After two rounds of allogeneic FMT, both the intestinal mucosal bleeding and edema significantly improved, as did the diversity of the gut microbiota. The positive outcome of allogeneic FMT in this case highlights the potential advantages that this procedure can offer patients with DC. However, few studies have focused on allogeneic FMT, and more in-depth research is needed to gain a better understanding.
Effect of Ce2O3 content on structure, viscosity, and melting properties of CaO-Al2O3-MgO-SiO2-Ce2O3 slag
Authors: Wang Lanqing , Zhu Hangyu , Chen Ji , Zhao Jixuan , Guo Shuai
Published: May 2024

To ensure the reliable operation of high aluminum steel smelting, it is common practice to employ low-reactivity CaO-Al2O3-based slag. Various analytical methods, including scanning electron microscopy with energy-dispersive X-ray spectroscopy, X-ray diffraction, Raman spectroscopy, and so on, are employed to investigate the impact of Ce2O3 content on the crystalline phase and structure within the CaO-Al2O3-MgO-SiO2 slag. Concurrently, the slag properties of viscosity and melting temperature are assessed. The findings reveal that the principal crystalline phases in the CaO-Al2O3-MgO-SiO2 slag include Ca3Al4MgO10, Ca3Al2O6, and MgO. Additionally, the introduction of Ce2O3 leads to the formation of the high melting temperature CaCeAlO4 phase, whose abundance correlates positively with the Ce2O3 content. Ce2O3 demonstrates efficient bridging oxygen bond disruption, causing the transformation of network former [AlO4]-tetrahedron into network modifier [AlO6]-octahedron. Simultaneously, Q4Al shifts to Q2Al and Q3Al in [AlO4]-tetrahedron, resulting in a marked reduction in degree of polymerization of slag. This reduction is evident in decreased viscosity and melting temperature, reaching the minimum value of 0.153 Pa·s and 1331 °C, respectively. However, the Ce2O3 content is beyond 15 wt%, Q2Al and Q3Al transform into Q4Al, which lead to an upward trend in high-temperature viscosity. Furthermore, as the temperature decreases, the precipitation of the CaCeAlO4 phase from the slag occurs. The content and precipitation temperature of CaCeAlO4 increase with rising Ce2O3 content, representing the primary factor behind the elevation of low-temperature viscosity and melting temperature.
Resisting Divides: Assimilation, Multiculturalism, and Place-Based Solidarity in Sápmi and Palestine
Authors: Carl Florian , Stagni Federica
Published: May 2024

Like roots reaching for the nourishment of familiar ground, generations of resistance lineages continue to weave a worldwide tapestry of solidarity. These efforts help to disrupt various forms of colonial violence, including under the guise of liberal democracies. One of the multiple mechanisms they target is how people and lands are pitted against one another through adversarial categories of difference. Such efforts are a powerful antidote to colonial fragmentations, mobilizing differences via shared goals based on grounded solidarities. This article seeks to answer how anti-colonial struggles in Palestine and Sápmi engage with three ways of structuring similarities and differences. We thereby utilize Coulthard’s (2014) framework of recognition politics, divided into (1) assimilation, (2) multiculturalism, and (3) place-based solidarity. Next to excerpts from local organizers and a speculative dialogue between interviewees, we reference Audre Lorde’s work to better understand the relational qualities of differences. Our research shows that the structural dominance of assimilatory and multiculturalist approaches to difference tends to stabilize injustices while normalizing colonial violence, including via Westernized peace politics like the Oslo Accords or state-led reconciliation initiatives. On the other hand, the integrity of place-based solidarity generates reciprocal relationships and interdependent responsibilities, which undermine colonial divide-and-conquer politics. With the help of our interviewees, this article provides a shared analysis to further the solidarity between the struggles of two of colonial modernity’s most critical fronts, Sápmi and Palestine.
Life Cycle Assessment for the Use of Waste Plastics in Asphalt Concrete Mixes
Authors: Diab Lara , Al-Qadi Imad L.
Published: May 2024

Improper waste disposal poses the risk of contaminating natural water bodies and soil. The low recycling rate of plastics and their fate in landfills are significant global environmental concerns. Efforts to increase the use of recycled plastics worldwide aim to address the hazardous consequences of improper plastic treatment. One potential solution is incorporating plastics as binder or mixture modifiers in asphalt concrete (AC) mixtures, which repurposes waste plastics while reducing environmental impacts related to AC production. This study calculated the environmental impacts of repurposing waste plastics, specifically low-density polyethylene and polystyrene, into modifiers in AC mixes. Wet and dry processes were considered. The environmental impacts of plastic-modified AC mixes were compared with those of styrene-butadiene-styrene (SBS)-modified mixes. The life cycle assessment covered the following processes: (1) collection, sorting, and shredding of waste plastics; (2) transportation of waste plastics from landfill to recycling facility and then to the asphalt plant; (3) supply and transportation of virgin materials; (4) production of AC mixtures; (5) transport of material and equipment to site; and (6) onsite operations. The study concluded that waste plastic-modified mixes outperformed SBS-modified mixtures with regard to environmental performance, except for ozone depletion resulting from certain recycling process activities. The high-shear mixing in the wet process had a significant impact. Sensitivity analyses revealed the influence of binder content and material transportation on the overall environmental assessment.
Novel composite BPH3 trifecta for robotic assisted simple prostatectomy (RASP) versus BPH6: A multicenter outcomes comparison
Authors: Bove Alfredo Maria , Pallares-Méndez Rigoberto , Brassetti Aldo , Mastroianni Riccardo , Tuderti Gabriele , Anceschi Umberto , D’Annunzio Simone , Ferriero Mariaconsiglia , Flammia Rocco Simone , Misuraca Leonardo , Proietti Flavia , Amparore Daniele , Porpiglia Francesco , Leonardo Costantino , Simone Giuseppe
Published: May 2024

Objectives:

To assess disobstructive proficiency of BPH3 trifecta in RASP according to different techniques.

Methods:

Baseline prostate volume (PV), uroflowmetry parameters and Validated questionnaires: IIEF, Incontinence severity index score (ISI), International prostatic symptoms score (IPSS), MSHQ, Quality of recovery (QOR), were recorded preoperatively and 12 months postoperatively. RASP was conducted using both the urethra-sparing (Madigan) technique and a non-urethral-sparing transvesical (Freyer) approach. Two groups were evaluated for achievement rates in terms of BPH-3 and BPH-6. BPH-3 was defined by a combination of: a reduction of ⩾30% in IPSS compared to baseline, ISI score ⩽ 4, and absence of complications beyond Clavien grade 1.

Results:

About 158 patients underwent RASP, with 93 undergoing the Madigan procedure and 65 the Freyer approach. Patients in the Madigan group were younger, with lower PV, baseline IPSS score, overactive symptoms (ISI score), but higher MSHQ and IIEF score, when compared to the Freyer population (all p < 0.02). At 12-month follow-up, patients who underwent the Madigan procedure reported shorter bladder irrigation time and time to catheter removal (both p < 0.001). As expected, Madigan patients also demonstrated superior postoperative IIEF and MSHQ scores (all p < 0.001). Postoperative complication incidence was higher in the Madigan cohort, mainly due to UTI ( p < 0.001). Although there were no differences in postoperative IPSS and Q-max between groups, the Madigan cohort presented with higher post void residue ( p < 0.001). BPH6 achievement was higher in the Madigan cohort (48% vs 28%) ( p < 0.001), while no difference was observed in BPH3 achievement rate.

Conclusion:

The BPH3 composite trifecta appears to be more suitable than BPH6 in assessing the proficiency in disobstructive symptoms relief after RASP.
Abnormality of Early White Matter Development in Tuberous Sclerosis Complex and Autism Spectrum Disorder: Longitudinal Analysis of Diffusion Tensor Imaging Measures
Authors: Srivastava Siddharth , Yang Fanghan , Prohl Anna K. , Davis Peter E. , Capal Jamie K. , Filip-Dhima Rajna , Bebin E. Martina , Krueger Darcy A. , Northrup Hope , Wu Joyce Y. , Warfield Simon K. , Sahin Mustafa , Zhang Bo ,   TACERN Study Group
Published: May 2024

Background: Abnormalities in white matter development may influence development of autism spectrum disorder in tuberous sclerosis complex (TSC). Our goals for this study were as follows: (1) use data from a longitudinal neuroimaging study of tuberous sclerosis complex (TACERN) to develop optimized linear mixed effects models for analyzing longitudinal, repeated diffusion tensor imaging metrics (fractional anisotropy, mean diffusivity) pertaining to select white matter tracts, in relation to positive Autism Diagnostic Observation Schedule–Second Edition classification at 36 months, and (2) perform an exploratory analysis using optimized models applied to all white matter tracts from these data. Methods: Eligible participants (3-12 months) underwent brain magnetic resonance imaging (MRI) at repeated time points from ages 3 to 36 months. Positive Autism Diagnostic Observation Schedule–Second Edition classification at 36 months was used. Linear mixed effects models were fine-tuned separately for fractional anisotropy values (using fractional anisotropy corpus callosum as test outcome) and mean diffusivity values (using mean diffusivity right posterior limb internal capsule as test outcome). Fixed effects included participant age, within-participant longitudinal age, and autism spectrum disorder diagnosis. Results: Analysis included data from n = 78. After selecting separate optimal models for fractional anisotropy and mean diffusivity values, we applied these models to fractional anisotropy and mean diffusivity of all 27 white matter tracts. Fractional anisotropy corpus callosum was related to positive Autism Diagnostic Observation Schedule–Second Edition classification (coefficient = 0.0093, P = .0612), and mean diffusivity right inferior cerebellar peduncle was related to positive Autism Diagnostic Observation Schedule–Second Edition classification (coefficient = –0.00002071, P = .0445), though these findings were not statistically significant after multiple comparisons correction. Conclusion: These optimized linear mixed effects models possibly implicate corpus callosum and cerebellar pathology in development of autism spectrum disorder in tuberous sclerosis complex, but future studies are needed to replicate these findings and explore contributors of heterogeneity in these models.
Evaluation of Gram Stain-Guided Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus Pneumonia in Intensive Care Unit Patients
Authors: Van Epps Johanna , Lepak Alexander J. , Schulz Lucas T. , Fish Jeffrey
Published: May 2024

Background: Despite high negative predictive values (NPVs) seen with methicillin-resistant Staphylococcus aureus (MRSA) nares polymerase chain reaction (PCR) assays, utilization of both respiratory sample Gram stain and MRSA nares PCR in patients with pneumonia may contribute to overuse of laboratory resources. The purpose of this study was to evaluate if a Gram stain demonstrating no Gram-positive organisms from a respiratory sample is sufficient to allow for de-escalation of vancomycin therapy. Methods: This single center study retrospectively identified intensive care unit (ICU) patients started on vancomycin for presumed pneumonia at University of Wisconsin (UW) Health in Madison, WI between August 2022 and March 2023. Patients with respiratory sample demonstrating no Gram-positives on Gram stain met inclusion criteria if the sample was ordered within 24 h of vancomycin initiation. The primary outcome was NPV of respiratory sample Gram stain demonstrating no Gram-positive organisms with respect to MRSA detection of the respiratory culture. Secondary outcomes included the NPV of combined MRSA nares PCR plus respiratory sample Gram stain, and difference in time to event in patients that had both a respiratory sample and MRSA nares PCR ordered. Results: A total of 370 patients were screened for study eligibility; of which 99 patients met inclusion criteria. NPV of respiratory sample Gram stain was 99% for MRSA culture. The combined NPV of respiratory sample Gram stain plus MRSA nares PCR was 98.9% for MRSA culture (n = 88). Respiratory sample was ordered 2.3 h faster compared to MRSA nares PCR (4.3 vs 6.6 h, P = .036). Respiratory sample Gram stain resulted 4.5 h faster compared to MRSA nares PCR (10.7 vs 15.2 h, P = .002). Conclusion: Respiratory sample Gram stains demonstrating no Gram-positive organisms may be used to de-escalate vancomycin and deprioritize the use of MRSA nares PCR.
Parametric investigation of thermal additive centrifugal abrasive flow machining process for enhancing productivity
Authors: Bhardwaj Anant , Srinivas Krovvidi , Chaudhary Rajiv
Published: May 2024

Thermal additive centrifugal abrasive flow machining hybrid of abrasive flow machining caters to low material removal issues which enhances the acceptability of the process. The present investigation investigates the different centrifugal force-generating electrode geometry performances in the thermal additive centrifugal abrasive flow machining process. The L27 orthogonal array is used for optimizing the process parameters (electrode type, current supply, and the duty cycle) and their effect on material removal and percentage improvement in surface finish (%Δ Ra) are analyzed. Based on the percentage contribution obtained from Taguchi analysis, electrode type is the prominent parameter for material removal (88.27%) and %Δ Ra (78.54%) followed by current (7.43% for material removal and 13.92% for %Δ Ra) and duty cycle (3.95% for material removal and 6.42% for %Δ Ra). The spline electrode with a curved blade is found optimum with 10 A current and 0.76 duty cycle. The average experimental value based on the design of the experiment and the predicted value for material removal is 10.373 and 10.881 mg, respectively. The average experimental value and the predicted value for percentage improvement in the surface are 42.24% and 43.71%, respectively. The percentage error between the predicted and experimental values for material removal and %Δ Ra is 4.66% and 3.15%, respectively.
Correlations on heat-transfer rate and friction factor using radial and axial v-cut geometry on a twisted tape in a double-pipe heat exchanger
Authors: Singh Sanjay Kumar , Kacker Ruchin , Gautam Satyam Shivam , Tandon Sourabh
Published: May 2024

This study explores the transformative potential of varying radial and axial v-cut angles within twisted tape inserts in the context of heat transfer enhancement within a double-pipe heat exchanger. The research is driven by the need to enhance energy efficiency in heat exchange systems, with a focus on understanding how v-cut angles influence heat-transfer rates, friction factors, and overall performance. Using water as the working medium, a comprehensive experimental investigation is conducted across a Reynolds number range of 5500–10,000. The findings reveal compelling correlations between the Nusselt number (Nu), friction factor ( f), and performance evaluation criteria concerning different v-cut angles within the twisted tape inserts. Remarkably, the study underscores the pivotal role of radial v-cut twisted tapes in elevating heat exchanger performance, surpassing even axial v-cut configurations. The Nusselt number achieves its pinnacle (96.51) at a Reynolds number of 10,000, whereas the highest friction factor (0.0582) and performance evaluation criteria (1.65) emerge at a Reynolds number of 5500, specifically with a 45-degree radial v-cut angle. This configuration showcases remarkable enhancements in the Nusselt number (98.68%), friction factor (38.87%), and performance evaluation criterion (39.36%) compared to a plain tube, underlining the transformative potential of optimized twisted tape inserts. The presented study offers more than theoretical insights; it provides practical guidelines for designing heat exchangers with superior performance. Derived correlations for the Nusselt number and friction factor, established through regression analysis involving key parameters such as Reynolds number (Re), Prandtl number (Pr), radial v-cut angle ( ϕ), and axial v-cut angle ( θ), demonstrate robust results within a narrow range of ± 5% for the Nusselt number and ±7% for the friction factor. In summary, this investigation not only advances our understanding of heat transfer enhancement but also presents tangible pathways for implementing enhanced heat exchanger designs, contributing significantly to energy-efficient thermal systems.
Defamilization? Not for everyone. Unequal labour-market participation among informal caregivers in Europe
Authors: Laschinski Miriam
Published: May 2024

Growing care dependencies among the elderly due to population ageing in Europe challenge the labour-market participation of informal caregivers. While familiarized care regimes incentivize family caregiving by providing many cash-for-care-benefits, resulting in reduced labour supply, defamiliarized care regimes allocate more public spending to care infrastructure, alleviating the care responsibilities placed on family members. At the same time, care provision on the micro-level is distributed unequally across gender, age, and socioeconomic status. The question then emerges: Does the labour-market participation of informal caregivers vary between and within countries depending on the social-expenditure policy of welfare states? To answer this research question, a multilevel design was used, employing SHARE data and macro-indicators from OECD and Eurostat databases. The results reveal higher probabilities of labour-market participation for informal caregivers in general when social expenditures on formal care infrastructure are higher. However, labour-market participation was observed as being unequally distributed among the heterogeneous group of persons with and without caregiving duties. Women and individuals of lower socioeconomic status did not benefit from social expenditures in the same way as their counterparts, leading to lower levels of labour-market participation.
Civil Legal Services and Survivor-Defined Justice: A Qualitative Study with US Civil Legal Attorneys for Sexual Assault Survivors
Authors: Palmer Jane E. , Lee Jacqueline , Michels Emily
Published: May 2024

In the United States and elsewhere, civil legal services are an overlooked strategy in the response to sexual assault. Contrary to the criminal legal system, civil legal remedies can offer supports that are specific to survivors’ immediate needs in the aftermath of sexual assault. To learn more about this legal strategy, we explored three areas: 1) civil legal needs of survivors; 2) barriers to seeking civil legal services; and 3) what survivor-defined justice might look like. In-depth interviews were conducted with 24 civil legal attorneys who work with survivors of sexual assault in the US. Results indicate that survivors have a multitude of overlapping legal needs outside of the criminal legal system, especially related to increasing agency, safety, and stability in their lives. Yet, several barriers exist that prevent access to these legal remedies. Despite these barriers, attorneys outlined how survivors’ lives have been positively affected by the services they offer. Attorneys also spoke to what “survivor-defined justice” might look like for their clients in this context. The results support the need to expand our conceptualization of justice beyond what the criminal legal system can offer. Implications for advancing civil remedies as a survivor-centered legal strategy are discussed.
Exploring Melezitose as a Potential Therapeutic Agent in Lung Cancer: Inhibitory Effects on Cell Proliferation and EMT-Mediated Signaling in A549 Cells
Authors: Zhou Qihui , Wu Ziyong , Cheng Xi , Zuo Zhigang , Fan Cunyu
Published: May 2024

Background

Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-related deaths. The study delves into melezitose, a naturally occurring compound known for its biocompatibility.

Purpose

This study aims to uncover its therapeutic potential and molecular mechanisms within lung cancer, particularly in A549 cells. Melezitose’s impact on inhibiting cell proliferation and influencing epithelial-mesenchymal transitions (EMT) was the primary focus.

Materials and Methods

In a time-dependent manner, A549 cells, representative of lung adenocarcinoma (LUAD), underwent melezitose treatment. Analysis of cytotoxicity by MTT assay, cell migration assay, and its responsible genes were analyzed by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) kit method.

Results

The MTT assay indicated a significant reduction in A549 cell growth after 48 hours of melezitose treatment. Additionally, melezitose induced G1 phase cell arrest and stimulated apoptosis in A549 cells. Subsequent determination of IC50 values represents the concentration at which melezitose inhibits 50% of cell growth. The study also investigated EMT-related gene expression like claudin 1 (CLD1), E-cadherin (ECADH), SNAIL1, SLUG, and vimentin (VIM) through RT-PCR. The findings revealed strong binding associations between melezitose and these EMT targets, suggesting a potential regulatory role of melezitose in impeding EMT processes.

Conclusion

Overall, this study illuminates the significant role of melezitose in lung cancer. Its observed inhibition of lung cancer cell proliferation and its influential impact on EMT-related gene expression highlights. Melezitose has potential as a therapeutic agent, particularly in the context of NSCC. The multifaceted effects of melezitose on A549 cells open promising avenues for advancing our understanding of this disease and developing innovative therapeutic strategies.
Inter-organisational human resource management and network orientation of worker representatives: a practice-based perspective
Authors: Helfen Markus , Sydow Jörg , Wirth Carsten
Published: May 2024

We develop a practice-based framework of inter-organisational human resource management that puts multi-employer work arrangements in inter-firm networks at its centre. By reinterpreting existing knowledge on multi-employer work arrangements and how they are managed, we delineate four processes in the assemblage of inter-organisational HR management. To illustrate the usefulness of our framework, we explore the question of whether and how an inter-organisational HR management develops in four exemplary cases of multi-employer work arrangements. These cases reveal that the quality and degree of inter-organisational HR management varies considerably, also depending on whether worker representatives show network awareness and orient their activities towards inter-organisational relations.