bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of anti-vascular endothelial growth factors in neovascular age-related macular degeneration and variables associated with visual acuity outcomes: Results from the EAGLE study
Authors: Staurenghi Giovanni , Bandello Francesco , Viola Francesco , Varano Monica , Barbati Giulia , Peruzzi Elena , Bassanini Stefania , Biancotto Chiara , Fenicia Vito , Furino Claudio , Vadalà Maria , Reibaldi Michele , Vujosevic Stela , Ricci Federico ,   on behalf of the EAGLE study investigators
Published: September 2021

Objective

To assess the overall effectiveness of anti-vascular endothelial growth factor (VEGF) therapy in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) in a clinical practice setting.

Study design

EAGLE was a retrospective, 2-year, cohort observational, multicenter study conducted in Italy that analyzed secondary data of treatment-naïve patients with nAMD. The primary endpoint evaluated the mean annualized number of anti-VEGF injections at Years 1 and 2. The main secondary endpoints analyzed the mean change in visual acuity (VA) from baseline and variables associated with visual outcomes at Years 1 and 2.

Results

Of the 752 patients enrolled, 745 (99.07%) received the first dose of anti-VEGF in 2016. Overall, 429 (57.05%) and 335 (44.5%) patients completed the 1- and 2-year follow-ups, respectively. At baseline, mean (standard deviation, SD) age was 75.6 (8.8) years and the mean (SD) VA was 53.43 (22.8) letters. The mean (SD) number of injections performed over the 2 years was 8.2 (4.1) resulting in a mean (SD) change in VA of 2.45 (19.36) (P = 0.0005) letters at Year 1 and −1.34 (20.85) (P = 0.3984) letters at Year 2. Linear regression models showed that age, baseline VA, number of injections, and early fluid resolution were the variables independently associated with visual outcomes at Years 1 and 2.

Conclusions

The EAGLE study analyzed the routine clinical practice management of patients with nAMD in Italy. The study suggested that visual outcomes in clinical practice may be improved with earlier diagnosis, higher number of injections, and accurate fluid resolution targeting during treatment induction.
PyPlutchik: Visualising and comparing emotion-annotated corpora
Authors: Semeraro Alfonso , Vilella Salvatore , Ruffo Giancarlo
Published: September 2021

The increasing availability of textual corpora and data fetched from social networks is fuelling a huge production of works based on the model proposed by psychologist Robert Plutchik, often referred simply as the “Plutchik Wheel”. Related researches range from annotation tasks description to emotions detection tools. Visualisation of such emotions is traditionally carried out using the most popular layouts, as bar plots or tables, which are however sub-optimal. The classic representation of the Plutchik’s wheel follows the principles of proximity and opposition between pairs of emotions: spatial proximity in this model is also a semantic proximity, as adjacent emotions elicit a complex emotion (a primary dyad) when triggered together; spatial opposition is a semantic opposition as well, as positive emotions are opposite to negative emotions. The most common layouts fail to preserve both features, not to mention the need of visually allowing comparisons between different corpora in a blink of an eye, that is hard with basic design solutions. We introduce PyPlutchik the Pyplutchik package is available as a Github repository (http://github.com/alfonsosemeraro/pyplutchik) or through the installation commandspiporconda. For any enquiry about usage or installation feel free to contact the corresponding author, a Python module specifically designed for the visualisation of Plutchik’s emotions in texts or in corpora. PyPlutchik draws the Plutchik’s flower with each emotion petal sized after how much that emotion is detected or annotated in the corpus, also representing three degrees of intensity for each of them. Notably, PyPlutchik allows users to display also primary, secondary, tertiary and opposite dyads in a compact, intuitive way. We substantiate our claim that PyPlutchik outperforms other classic visualisations when displaying Plutchik emotions and we showcase a few examples that display our module’s most compelling features.
Spectral and time-resolved photoluminescence of human platelets doped with platinum nanoparticles
Authors: Matveeva Karina , Zyubin Andrey , Demishkevich Elizaveta , Rafalskiy Vladimir , Moiseeva Ekaterina , Kon Igor , Kundalevich Anna , Butova Viktoria , Samusev Ilia
Published: September 2021

This paper describes a detailed study of spectral and time-resolved photoprocesses in human platelets and their complexes with platinum (Pt) nanoparticles (NPs). Fluorescence, quantum yield, and platelet amino acid lifetime changes in the presence and without femtosecond ablated platinum NPs have been studied. Fluorescence spectroscopy analysis of main fluorescent amino acids and their residues (tyrosine (Tyr), tryptophan (Trp), and phenylalanine (Phe)) belonging to the platelet membrane have been performed. The possibility of energy transfer between Pt NPs and the platelet membrane has been revealed. Förster Resonance Energy Transfer (FRET) model was used to perform the quantitative evaluation of energy transfer parameters. The prospects of Pt NPs usage deals with quenching-based sensing for pathology’s based on platelet conformations as cardiovascular diseases have been demonstrated.
Loss of miR-1469 expression mediates melanoma cell migration and invasion
Authors: DiVincenzo Mallory J. , Barricklow Zoe , Schwarz Emily , Moufawad Maribelle , Howard J. Harrison , Yu Lianbo , Chung Catherine , Gru Alejandro A. , Carson William E.
Published: September 2021

Tumor ulceration is considered one of the most prognostically significant findings in primary cutaneous melanoma, associated with decreased disease-free and overall survival. However, the unique features associated with ulcerated melanoma that contribute to a poor prognosis in affected patients remain poorly defined. microRNAs are small, non-coding RNAs that function to inhibit expression of specific gene targets, therefore altering the functions of cells in which they are expressed. miR-1469 is a novel miR with significantly decreased expression in ulcerated melanoma tissue relative to non-ulcerated tumors. We hypothesized that loss of miR-1469 expression in melanoma contributes to altered tumor cell functions mediating disease progression. Transfection of a miR-1469 mimic resulted in a significant reduction in the migratory and invasive capacity of the CHL1 and MEL39 melanoma cell lines (>58.1% reduction, p < 0.0332), as well as the invasive capacity of the A375 melanoma cell line (>50% reduction, p < 0.0021). Expression of myeloid cell leukemia-1 (MCL1), a miR-1469 target gene, was reduced in the A375 and MEL39 cell lines by immunoblot. No significant differences in viability, resistance to apoptotic stimuli, or proliferation were observed following transfection. These findings together demonstrate how migration and invasion are specific functions through which miR-1469 expression in melanoma cells can contribute to the differences in disease progression associated with tumor ulceration.
On the formalism of the screening paradox
Authors: Balayla Jacques
Published: September 2021

Bayes’ Theorem imposes inevitable limitations on the accuracy of screening tests by tying the test’s predictive value to the disease prevalence. The aforementioned limitation is independent of the adequacy and make-up of the test and thus implies inherent Bayesian limitations to the screening process itself. As per the WHO’s Wilson − Jungner criteria, one of the prerequisite steps before undertaking screening is to ensure that a treatment for the condition screened for exists. However, when applying screening programs in closed systems, a paradox, henceforth termed the “screening paradox”, ensues. If a disease process is screened for and subsequently treated, its prevalence would drop in the population, which as per Bayes’ theorem, would make the tests’ predictive value drop in return. Put another way, a very powerful screening test would, by performing and succeeding at the very task it was developed to do, paradoxically reduce its ability to correctly identify individuals with the disease it screens for in the future—over some time t. In this manuscript, we explore the mathematical model which formalizes said screening paradox and explore its implications for population level screening programs. In particular, we define the number of positive test iterations (PTI) needed to reverse the effects of the paradox. Given their theoretical nature, clinical application of the concepts herein reported need validation prior to implementation. Meanwhile, an understanding of how the dynamics of prevalence can affect the PPV over time can help inform clinicians as to the reliability of a screening test’s results.
Effect of different long-term fertilizer managements on soil nitrogen fixing bacteria community in a double-cropping rice paddy field of southern China
Authors: Tang Haiming , Li Chao , Shi Lihong , Xiao Xiaoping , Cheng Kaikai , Wen Li , Li Weiyan
Published: September 2021

Soil microorganism plays an important role in nitrogen (N) fixation process of paddy field, but the related information about how soil microorganism that drive N fixation process response to change of soil phy-chemical characteristics under the double-cropping rice (Oryza sativa L.) paddy field in southern of China is need to further study. Therefore, the impacts of 34-years different long-term fertilization system on soil N-fixing bacteria community under the double-cropping rice paddy field in southern of China were investigated by taken chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) method in this paper. The field experiment were set up four different fertilizer treatments: chemical fertilizer alone (MF), rice straw and chemical fertilizer (RF), 30% organic manure and 70% chemical fertilizer (OM), and unfertilized as a control (CK). This results showed that compared with CK treatment, the diversity index of cbbLR and nifH genes with OM and RF treatments were significantly increased (p<0.05), respectively. Meanwhile, the abundance of cbbLR gene with OM, RF and MF treatments were increased by 23.94, 12.19 and 6.70×107 copies g-1 compared to CK treatment, respectively. Compared with CK treatment, the abundance of nifH gene with OM, RF and MF treatments were increased by 23.90, 8.82 and 5.40×109 copies g-1, respectively. This results indicated that compared with CK treatment, the soil autotrophic azotobacter and nitrogenase activities with OM and RF treatments were also significantly increased (p<0.05), respectively. There were an obvious difference in features of soil N-fixing bacteria community between application of inorganic fertilizer and organic manure treatments. Therefore, this results demonstrated that abundance of soil N-fixing bacteria community in the double-cropping rice paddy field were increased by long-term applied with organic manure and crop residue managements.
Interpreting COVID-19 deaths among nursing home residents in the US: The changing role of facility quality over time
Authors: Das Gupta Debasree , Kelekar Uma , Turner Sidney C. , Sule Anupam A. , Jerman Taya G.
Published: September 2021

A report published last year by the Centers for Medicare & Medicaid Services (CMS) highlighted that COVID-19 case counts are more likely to be high in lower quality nursing homes than in higher quality ones. Since then, multiple studies have examined this association with a handful also exploring the role of facility quality in explaining resident deaths from the virus. Despite this wide interest, no previous study has investigated how the relation between quality and COVID-19 mortality among nursing home residents may have changed, if at all, over the progression of the pandemic. This understanding is indeed lacking given that prior studies are either cross-sectional or are analyses limited to one specific state or region of the country. To address this gap, we analyzed changes in nursing home resident deaths across the US between June 1, 2020 and January 31, 2021 (n = 12,415 nursing homes X 8 months) using both descriptive and multivariable statistics. We merged publicly available data from multiple federal agencies with mortality rate (per 100,000 residents) as the outcome and CMS 5-star quality rating as the primary explanatory variable of interest. Covariates, based on the prior literature, consisted of both facility- and community-level characteristics. Findings from our secondary analysis provide robust evidence of the association between nursing home quality and resident deaths due to the virus diminishing over time. In connection, we discuss plausible reasons, especially duration of staff shortages, that over time might have played a critical role in driving the quality-mortality convergence across nursing homes in the US.
A broad-spectrum and highly potent human monoclonal antibody cocktail for rabies prophylaxis
Authors: Kim Pan Kyeom , Ahn Jung Sun , Kim Cheol Min , Seo Ji Min , Keum Sun Ju , Lee Hyun Joo , Choo Min Joo , Kim Min Soo , Lee Jun Young , Maeng Ki Eun , Shin Ji Young , Yi Kye Sook , Osinubi Modupe O. V. , Franka Richard , Greenberg Lauren , Shampur Madhusudana , Rupprecht Charles E. , Lee Soo Young
Published: September 2021

Post-exposure prophylaxis (PEP) is highly effective in preventing disease progression of rabies when used in timely and appropriate manner. The key treatment for PEP is infiltration of rabies immune globulin (RIG) into lesion site after bite exposure, besides wound care and vaccination. Unfortunately, however, RIG is expensive and its supply is limited. Currently, several anti-rabies virus monoclonal antibody (mAb) products are under development as alternatives to RIG, and two recently received regulatory approval in India. In this study, fully human mAbs that recognize different rabies virus glycoprotein conformational antigenic site (II and III) were created from peripheral blood mononuclear cells of heathy vaccinated subjects. These mAbs neutralized a diverse range of lyssavirus types. As at least two anti-rabies virus mAbs are recommended for use in human PEP to ensure broad coverage against diverse lyssaviruses and to minimize possible escape variants, two most potent mAbs, NP-19-9 and 11B6, were selected to be used as cocktail treatment. These two mAbs were broadly reactive to different types of lyssaviruses isolates, and were shown to have no interference with each other. These results suggest that NP-19-9 and 11B6 are potent candidates to be used for PEP, suggesting further studies involving clinical studies in human.
Volunteers’ compassion fatigue, compassion satisfaction, and post-traumatic growth during the SARS-CoV-2 lockdown in Spain: Self-compassion and self-determination as predictors
Authors: Gonzalez-Mendez Rosaura , Díaz Matilde
Published: September 2021

Volunteers have played an important role by supporting essential services that have been overwhelmed during the most critical moments of the SARS-CoV-2 pandemic. Hence, nonprofit organizations may be interested in preventing negative consequences of these volunteers’ exposure to potentially traumatic events. The aim of this cross-sectional study was twofold. First, to examine to what extent self-compassion and self-determination would contribute to differentiating between volunteers with different levels of compassion fatigue, compassion satisfaction, and post-traumatic growth. Second, to identify the best predictors of the most extreme levels of each outcome. Participants were 211 Spanish Red Cross volunteers (60.7% women), who completed a survey. They were separately classified into three groups (low, medium, and high) according to the 33rd and 66th percentile scores on each outcome (compassion fatigue, compassion satisfaction, and post-traumatic growth). Univariate analyses of variance and post-hoc comparisons revealed that self-compassion and self-determination contributed differently to distinguishing between levels of each outcome. Volunteers lowest in compassion fatigue stood out for showing fewer non-compassionate strategies and more mindfulness than the other groups. Moreover, those higher in satisfaction compassion also showed lower use of unhealthy strategies and higher scores in all other predictive variables. Volunteers highest in post-traumatic growth showed higher self-kindness and satisfaction of all psychological needs. Binary logistic regressions allowed for the identification of predictors of belonging to the most extreme groups. The protective factors may be useful to guide volunteers’ self-care and help them thrive in the face of critical service demands.
Real-world evaluation of costs of illness for pneumonia in adult patients in Dubai—A claims database study
Authors: Al Dallal Sara Ahmad Mohammad , Farghaly Mohamed , Ghorab Ahmed , Elaassar Mostafa , Haridy Hammam , Awad Nancy , Chickballapur Ramachandrachar Badarinath , Natarajan Ashok
Published: September 2021

Background

Pneumonia is a significant cause of morbidity and mortality among adults globally. This retrospective cohort analysis assessed the pneumonia burden and related healthcare resource utilization and costs in the at-risk (low, medium, and high-risk) adult patients in Dubai, United Arab Emirates (UAE).

Methods

The claims data from January 1, 2014 to June 30, 2019 were extracted from the Dubai Real-World Claims Database for patients, aged ≥18 year, having at least 1 pneumonia claim. Data for the inpatient, outpatient and emergency visits were assessed for 12-months, before (pre-index) and after (follow-up) a pneumonia episode. Healthcare costs were calculated based on dollar value of 2020.

Results

Total 48,562 records of eligible patients were analyzed (mean age = 39.9 years; low [62.1%], medium [36.2%] and high [1.7%] risk cohorts). Mean all-cause healthcare costs were approximately >45% higher in the follow-up period (1,947 USD/patient) versus pre-index period (1,327 USD/patient). During follow-up period, the mean annual pneumonia incidence rate was 1.3 episodes, with a similar pattern across all cohorts. Overall, mean claims and costs (USD) per patient (all-cause) were highest in the high-risk cohort in the follow-up period (claims: overall, 11.6; high-risk, 22.0; medium-risk, 13.9; low-risk, 9.9; costs: high-risk, 14,184; medium-risk, 2,240; low-risk, 1,388). Similarly, the mean pneumonia-related costs (USD) per patient were highest for the high-risk cohort (overall: 1,305; high-risk, 10,207; medium-risk, 1,283; low-risk, 882), however, the claims were similar across cohorts (claims/patient: overall: 2.0; high-risk, 1.9; medium-risk, 2.2; low-risk, 1.9). Most all-cause and pneumonia-related costs were due to inpatient visits (4,901 and 4,818 USD respectively), while outpatient (1,232 and 166 USD respectively) and emergency visits (347 and 206 USD respectively) contributed significantly lesser.

Conclusions

Pneumonia imposes a significant healthcare burden in the UAE, especially in the high-risk patients with severe comorbidities. These findings would guide clinicians and policy makers to make informed decisions.
Longitudinal association between movement behaviours and depressive symptoms among adolescents using compositional data analysis
Authors: Sampasa-Kanyinga Hugues , Colman Ian , Dumuid Dorothea , Janssen Ian , Goldfield Gary S. , Wang Jian Li , Patte Karen A. , Leatherdale Scott T. , Chaput Jean-Philippe
Published: September 2021

Background

Research examining the associations between movement behaviours and mental health indicators within a compositional framework are sparse and limited by their cross-sectional study design. This study has three objectives. First, to describe the change in movement behaviour composition over time. Second, to explore the association between change in movement behaviour composition and change in depressive symptoms. Third, to explore how reallocations of time between movement behaviours are associated with changes in depressive symptoms.

Methods

Longitudinal data of 14,620 students in grades 9–12 (mean age: 14.9 years) attending secondary schools in Canada (Ontario, British Columbia, Alberta, Quebec) were obtained from two waves (2017/18, 2018/19) of the COMPASS study. Moderate-to-vigorous physical activity (MVPA), recreational screen time, and sleep duration were self-reported. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale (Revised)−10 (CESD-R-10). Compositional data analyses using pivot coordinates and compositional isotemporal substitution for longitudinal data were used to analyse the data. Analyses accounted for school clustering, were stratified by gender and age (< or ≥ 15 years), and were adjusted for race/ethnicity, body mass index z-score, baseline movement behaviour composition, and baseline depressive symptoms.

Results

There were significant differences in movement behaviour composition over time across all subgroups. For example, the relative contributions of MVPA and sleep duration to the movement behaviour composition decreased over time while screen time increased among younger boys and girls and older girls. Increasing sleep duration relative to the remaining behaviours (i.e. screen time and MVPA) was associated with lower depressive symptoms among all subgroups. Increasing screen time relative to the remaining behaviours (i.e. MVPA and sleep duration) was associated with higher depressive symptoms among all subgroups. Increasing MVPA relative to the remaining behaviours (i.e. screen time and sleep duration) was associated with lower depressive symptoms in older girls only. Isotemporal substitution estimates indicated that decreasing screen time by 60 minutes/day and replacing that time with 60 minutes of additional sleep is associated with the largest change in depressive symptoms across all subgroups.

Conclusions

Findings from this prospective analysis suggest that increased sleep duration and reduced screen time are important determinants of lower depressive symptoms among adolescents.
Poem for Sugi
Authors: Andreyev Julie
Published: September 2021

Poem
Kearifan Lokal Epigrafi Islam Masa Majapahit pada Makam Nisan Troloyo
Authors:   UIN Sunan Ampel Surabaya, Mashud Imam
Published: September 2021

Satu kearifan lokal yang saat ini mulai meredup di kalangan bangsa kita adalah kemampuan untuk menyeleksi, memfilter, dan menerima segala macam bentuk perbedaan. Di tengah gempuran arus globalisasi yang menghantam kita dari segala sisi kehidupan membuat kita tak berkutik dan cenderung menerima begitu saja budaya asing yang datang. Kondisi ini seakan menyiratkan kealpaan bahwa kita sejatinya adalah bangsa yang besar bahkan sebelum proklamasi kemerdekaan Indonesia dikumandangkan. Sebutlah masa Kerajaan Majapahit yang mencatatkan sejarah bahwa masyarakat Islam Nusantara pada saat itu tidak serta merta menerima begitu saja budaya asing yang datang. Masyarakat Islam Nusantara terlebih dahulu mengubah kebudayaan asing yang masuk dan menyesuaikannya dengan karakteristik bangsa. Melalui buku ini, pembaca diajak untuk menggali kembali nilai-nilai kearifan lokal bangsa pada zaman Kerajaan Majapahit melalui bukti-bukti arkeologis yang banyak ditemukan di nisan-nisan Kompleks Pemakaman Islam Troloyo. Nilai-nilai yang dimaksud adalah kekayaan pengetahuan tradisional masyarakat masa lampau dalam mengubah kebudayaan asing sesuai dengan karakteristik budaya lokal. Dengan demikian, kehadiran buku ini diharapkan dapat menambah kekayaan narasi warisan budaya Islam di Majapahit serta dapat mengangkat kembali nilai-nilai luhur pluralisme dan toleransi dalam jiwa setiap individu.
Mikrofasies Batugamping: Studi Batugamping Paleogen-Neogen di Indonesia Bagian Barat
Authors:   Kementerian Energi dan Sumber Daya Mineral, Maryanto Sigit
Published: September 2021

Batugamping yang berumur Paleogen-Neogen tersingkap cukup baik di tiga pulau utama di Indonesia Bagian Barat, yaitu Sumatera, Jawa dan Kalimantan. Hal ini tentu tidak terlepas dari keadaan geologi regional Asia Tenggara pada Paleogen-Neogen, yang mana ketiga pulau ini masih merupakan satu kesatuan, yaitu Dangkalan Sunda. Kesamaan runtunan stratigrafi Neogen di ketiga wilayah ini menghasilkan formasi batugamping yang seumur. Pembahasan mengenai mikrofasies batugamping, dimulai dengan pengertian, konsep dan metode analisis mikrofasies. Pembahasan yang tidak kalah penting adalah pengenalan mengenai batugamping itu sendiri, seperti komponen, tekstur, struktur dan klasifikasi batugamping. Fasies batugamping terbagi menjadi fasies-fasies: cekungan, landaian laut terbuka, tepi landaian dalam, lereng depan, tepi paparan, paparan tertampi, landaian laguna atau paparan terbuka, paparan terbatas, dan paparan penguapan. Sembilan fasies batugamping ini selanjutnya terbagi menjadi dua puluh enam standar mikrofasies, dengan kriteria yang berbeda-beda pada masing-masing standar mikrofasies. Beberapa contoh mikrofasies yang akan dibahas dalam buku ini, antara lain: Formasi Baturaja di Sumatera Selatan, Formasi Rajamandala di Jawa Barat, Formasi Jonggrangan di Yogyakarta, Formasi Sentolo di Yogyakarta, Formasi Wonosari di Jawa Timur, dan Formasi Berai di Kalimantan Selatan
Efektivitas Granulocyte Colony Stimulating Factor untuk Anak dengan Acute on Chronic Liver Failure
Authors: Alatas Fatima Safira , Nasution Kholisah , Kadim Muzal
Published: September 2021

Latar belakang. Gagal hati akut pada penyakit hati kronik (acute on chronic liver failure/ACLF) memiliki angka mortalitas tinggi dan saat ini terapi utamanya ialah transplantasi hati. Terapi dengan granulocyte colony stimulating factor (GCSF) bermanfaat bagi perbaikan fungsi hati dan mengurangi angka kematian yang cepat pada dewasa dengan ACLF.Tujuan. Melakukan telaah kritis efektivitas GCSF pada pasien anak dengan ACLF untuk memperbaiki fungsi hati.Metode. Penelusuran literatur melalui database Pubmed/Medline, Cochrane, Google Scholar, serta Paediatrica Indonesiana, dan Sari Pediatri 29 Juni 2020.Hasil. Terdapat satu studi acak yang sahih dengan subjek penelitian anak yang menunjukkan perbedaan skor Child-Pugh dan Pediatric End-stage Liver Disease (PELD) di hari ke-14 pemberian injeksi GCSF, tetapi tidak ada perbedaan skor di hari ke-30 dan 60. Skor PELD pada penelitian dipakai untuk anak usia kurang dari 12 tahun, sementara untuk anak lebih besar seperti pada kasus seharusnya memakai skor Model for End-stage Liver Disease (MELD) yang ditunjukkan studi pada kelompok dewasa.Kesimpulan. Terapi GCSF subkutan pada pasien anak dengan ACLF berpotensi efektif memperbaiki fungsi hati yang dinilai dengan skor Child-Pugh dan MELD atau PELD. Untuk dapat menjaga efektifitas terapi lebih lama, dapat dipertimbangkan untuk memperpanjang durasi pemberian GCSF dan memberikannya lebih dini.
Diagnosis Infeksi Dengue di Era Pandemi COVID-19
Authors: Karyanti Mulya Rahma , Setyati Pinka Nurashri
Published: September 2021

Latar belakang. Penegakan diagnosis infeksi dengue menjadi tantangan di era pandemik COVID-19. Kasus misdiagnosis dan ko-infeksi antara infeksi dengue dengan COVID-19 telah dilaporkan karena adanya kemiripan gejala klinis maupun pemeriksaan laboratorium. Keterlambatan atau kesalahan penegakan diagnosis dapat menimbulkan kerugian pada pasien, maupun petugas kesehatan. Tujuan. Mendapatkan strategi penegakan diagnosis infeksi dengue yang cepat dan tepat pada era pandemi COVID-19.Metode. Penelusuran artikel melalui database ilmiah.Hasil. Infeksi dengue dan COVID-19 memiliki perbedaan patofisiologi dan target organ. Kedua penyakit tersebut memiliki ciri khas yang sama yaitu terjadinya disfungsi endotel. Terdapat perbedaan karakteristik demam dimana infeksi dengue dengan saddleback fever dan COVID-19 prolonged fever. Gejala saluran pernapasan lebih umum ditemui pada pasien COVID-19 (76%) dibandingkan pada infeksi dengue (21,5%). Sementara itu, gejala gastrointestinal berupa nyeri abdomen, muntah persisten merupakan gejala warning signs penting pada infeksi dengue, sedangkan diare dapat terjadi pada COVID-19. Manifestasi perdarahan pada infeksi dengue terutama dapat berupa petekie, epistaksis, gusi berdarah atau perdarahan saluran cerna, namun pada COVID-19 tidak terjadi. Pada infeksi dengue pada fase awal demam dapat timbul muka kemerahan (flushing) dan fase penyembuhan muncul rash konvalesen yang dapat disertai rasa gatal pada ektremitas, sementara ruam eritematosa adalah temuan pada COVID-19. Pemeriksaan laboratorium yang cepat, mudah, praktis dan tersedia dalam praktek untuk konfirmasi infeksi dengue dilakukan pemeriksaan antigen NS1 dengue, sedangkan konfirmasi COVID-19 dilakukan pemeriksaan PCR SARS-CoV-2 dari swab naso dan orofaring.Kesimpulan. Infeksi dengue dan COVID-19 memiliki gejala klinis dan temuan laboratorium yang serupa. Diagnosis infeksi dengue pada era pandemic COVID-19 dapat dikonfirmasi dengan antigen NS1 bersamaan dengan PCR SARS-C0V-2.
Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System
Authors: Chang Lin , Lacy Brian E. , Moshiree Baha , Kassebaum Amy , Abel Jessica L. , Hanlon Jennifer , Bartolini Wilmin , Boinpally Ramesh , Bochenek Wieslaw , Fox Susan M. , Mallick Madhuja , Tripp Ken , Omniewski Nicholas , Shea Elizabeth , Borgstein Niels
Published: September 2021

INTRODUCTION:

Linaclotide improves abdominal pain and constipation in patients with constipation-predominant irritable bowel syndrome (IBS-C). Patients report additional bothersome abdominal symptoms of bloating and discomfort. The intention of this study was to evaluate linaclotide's efficacy in relieving IBS-C-related abdominal symptoms (bloating, discomfort, and pain) using a novel multi-item Abdominal Score (AS).

METHODS:

Patients with IBS-C with abdominal pain ≥3 (0–10 scale) were randomized to linaclotide 290 μg or placebo daily for 12 weeks. The AS, derived from the Diary for IBS Symptoms-Constipation, is the average of abdominal bloating, discomfort, and pain at their worst (0 = none, 10 = worst possible). The primary end point was overall change from baseline (CFB) in AS. Secondary end points included CFB in 12-week AS evaluated using cumulative distribution function and 6-week/12-week AS responder (AS improvement ≥2 points for ≥6-week/12-week).

RESULTS:

Overall, 614 patients (mean age 46.7 years; 81% female) were randomized. All prespecified end points showed significant benefit of linaclotide vs placebo. The mean overall CFB AS reduction for linaclotide was −1.9 vs −1.2 for placebo (P < 0.0001); the 6-week/12-week AS responder rate was 40.5% for linaclotide vs 23.4% for placebo (odds ratio = 2.2 [95% confidence interval, 1.55–3.12; P < 0.0001]). Diarrhea was the most common treatment-emergent adverse event (linaclotide = 4.6%, placebo = 1.6%).

DISCUSSION:

Linaclotide significantly reduced multiple abdominal symptoms important to patients with IBS-C (bloating, discomfort, and pain) compared with placebo, as measured by a novel multi-item AS. The AS, derived from the Diary for IBS Symptoms-Constipation, should be considered for use in future IBS-C clinical studies to measure clinically meaningful improvements beyond traditional end points.
Continuing Medical Education Questions: September 2021
Authors: Aytaman Ayse
Published: September 2021

Article Title: Initial Evaluation, Long-Term Monitoring, and Hepatocellular Carcinoma Surveillance of Chronic Hepatitis B in Routine Practice: A Nationwide US Study
Der Alltag (in) der Stadtgeographie
Authors: Franz Yvonne , Strüver Anke
Published: September 2021

Yvonne Franz und Anke Strüver verbinden in diesem Beitrag ein relationales Raumverständnis mit der gelebten Alltagspraxis, indem sie explizit den ›Blick ins Alltagsleben‹ lenken. Damit soll ein konzeptionelles Verständnis urbaner Mensch-Umweltbeziehungen auf Quartiersebene gelingen, das die Identifikation von Komplexitäten und lokaler Differenzierung gleichermaßen erlaubt.
Alltagstheoretische Wendungen im Feld der Internationalen Urbanistik
Authors: Knierbein Sabine
Published: September 2021

Sabine Knierbein erforscht Transformationen des Alltagslebens und leitet daraus einen alltagstheoretischen Ansatz in der Internationalen Urbanistik ab. Forschende in den Urban Studies beziehen sich wiederholt auf die Werke Henri Lefebvres (1974, 1967, 1970). Sein im Hintergrund in drei Bänden angelegtes Jahrhundertwerk ›La Critique de la Vie Quotidienne‹ (1947, 1961, 1981) verbleibt jedoch weitgehend unterbelichtet, obwohl vielerorts empirische Befunde auf manifeste Transformationen des Alltagslebens in den Städten verweisen und alltagstheoretische Wendungen im Feld der Internationalen Urbanistik daher dringlich wären. Lefebvres Kritik des Alltagslebens wird im Beitrag in ihrem soziohistorischen Entstehungskontext beleuchtet und um jüngere alltagstheoretische Ansätze erweitert. Wieviel Lefebvre braucht die Urbanistik in krisengerüttelten, heutigen Zeiten noch? Welche Rolle spielt der Alltag in seiner frühen Kritik an Interdisziplinarität im positivistischen Forschungskontext der Stadtforschung? Können wir mit Hilfe seines Werkes den wichtigen urbanistischen Fokus auf das Alltagsleben und den gelebten Raum konstruktiv in das frühe 21. Jahrhundert bugsieren? Denn in der zweiten Dekade des frühen 21. Jahrhunderts scheint nichts mehr, wie es war. Vor allem das Alltagsleben nicht.
Brücke, Switchboard, Theke - Working Girls vor Ort
Authors: Mund Verena
Published: September 2021

In Unter den Brücken sieht man die Frauen oben auf den Brücken. Am Fenster ihres Ullstein-Büros imaginiert Vicki Baum die Idee einer Telefonistin vor der Schaltwand und transferiert so ihren Roman in ein Theaterstück. Baum, die Telefonistin und die Frauen am Brückengeländer kehren alle den Rücken zum übrigen Raum. Und genauso ausgerichtet sitzen auch die Studierenden bei den berühmten Sit-ins der US-Bürgerrechtsbewegung am Lunch Counter. Kaum bekannt hingegen ist der Kampf der zweiten Frauenbewegung um den Zugang zu Bars, der weniger an der Theke als vor Gericht ausgefochten wurde. Verena Mund untersucht diese Orte des Arbeitsalltags in Bildern, Filmen und Texten sowie ihre Implikationen für Handlungsmacht.
Szene, Habitus und Metaphorik
Authors: Schumacher Rolf
Published: September 2021

Psychotherapie ist jene Disziplin, die sich explizit mit den Bedingungen der Veränderbarkeit des Menschen befasst. Der Psychologische Psychotherapeut Rolf Schumacher gewährt neue Einblicke in die psychotherapeutische Praxis und fasst sie als professionelle Form sozialer, intersubjektiver Praxis — mit drei dokumentierten vollständigen Therapieverläufen als Fallbeispiele. Das Ziel dabei ist, ein integratives und eigenständiges Paradigma für die Psychotherapie auf erkenntnistheoretischer Grundlage zu begründen, das eine »praxeologische Theorie psychotherapeutischer Profession« und ein praxisorientiertes psychotherapeutisches Veränderungsmodell fördert. Dieser Ansatz ermöglicht auch eine Psychotherapiewissenschaft als (kritische) Disziplin der Humanwissenschaften, die natur-, sozial- und geisteswissenschaftliche Erkenntnisse integrieren kann.
Das Fremdwerden der eigenen Stadt
Authors: Riedel Lisanne
Published: September 2021

Ständige Erneuerung, Erweiterung und rigoroser Umbau prägen die Stadt Istanbul - insbesondere seit den 1950er Jahren. Was bedeutet eine derart rasante Urbanisierung für ihre Einwohner*innen? Welche (neuen) Räume werden in der Megacity relevant? Verliert die Stadt als Ort an Bedeutung und wird »just a spot«? Lisanne Riedel verbindet biographisch-narrative Interviews mit dem sozialräumlichen Erleben und rekonstruiert urban-migrantische Lebensgeschichten, die von sozialen Aufstiegen handeln, aber auch von Entfremdung und Überforderung durch die sich stetig verändernde Umwelt.
Curupira und Kohlenstoff
Authors: Meurer Michaela
Published: September 2021

Für den Schutz der Amazonaswälder Brasiliens bieten die gemeindebasiert verwalteten Nutzreservate Resex großes Potential. Michaela Meurer befasst sich detailliert mit der Vielfalt von Nutzungsregeln in der Resex Tapajós-Arapiuns, die sich im Zuge der gemeinsamen Verwaltung durch Staat, Zivilgesellschaft und Lokalbevölkerung herausgebildet haben. Die facettenreiche Ethnographie vermittelt einen fundierten Einblick in soziale Realitäten des heutigen Amazoniens und erweitert die anthropologische Theoriebildung um eine praxistheoretische Ausgestaltung Politischer Ontologie.
Mehr Mut zum Altern
Authors: Behnke-Vonier Cornelia , Vonier Herbert
Published: September 2021

Die hoch entwickelte Gesellschaft ist auch eine areligiöse Gesellschaft. Eine Gesellschaft, die mit Religion im Wortsinn, nämlich der Rückbindung des Menschen an so etwas wie einen Ursprung, fast nichts mehr anzufangen weiß. Diese Abkoppelung der »Wissensgesellschaft« vom alten Wissen macht insbesondere das Leben alter Menschen ärmer. Cornelia Behnke-Vonier und Herbert Vonier verknüpfen daher sozialphilosophische Betrachtungen mit den überlieferten Erzählungen rund um die biblische Schöpfungsgeschichte: Die alten Geschichten erzählen uns vom Sinn des Lebens und des Alters.
Henning von Rittersdorf: Das Deutsche Schicksal
Authors: Etzemüller Thomas
Published: September 2021

Der Rassenanthropologe Henning von Rittersdorf ist eine fiktive Gestalt. Aber es hätte ihn geben können. Er ist der Idealtypus eines deutschen Wissenschaftlers, der durch drei politische Systeme hindurchmäandert ist, sich mühelos in das »Dritte Reich« eingefügt und kaum mühevoller wieder herausgefunden hat. 1969 legte er eine Dokumentensammlung als Beweis vor, dass er stets ein Wissenschaftler gewesen sei, der nur der »Sache« gedient habe, »missbraucht« durch die Nationalsozialisten. Doch durch Streichungen, Kommentare und Randbemerkungen verlor er die Deutungshoheit über sein Material und bestätigte ungewollt seine tiefgehende Verstrickung in den Nationalsozialismus. Thomas Etzemüller bietet eine lebendige, doku-fiktionale Innensicht aus dem Leben eines Rassenanthropologen. Und macht deutlich, wie romanhaft die zugrunde liegende Realität gewesen ist — gleichwohl sie fürchterliche, reale Effekte gezeitigt hat.
Information Literacy Skills among the Masters Students of Social Sciences Departments of Mizoram University and Tezpur University A Comparative Study
Authors: Verma Manoj Kumar , Shukla Ravi
Published: September 2021

This paper highlights the comparison of information literacy skills among the master’s students of social sciences departments of Mizoram University (MZU) and Tezpur University (TZU). The primary data collected by using survey method and a structured 595 questionnaires were distributed among the respondents in which 522 (87.73 %) of questionnaires were received. The majority of the respondents were female in both the universities in compared to male respondents. Mizoram Universty students have more awareness of using library services in comparison to Tezpur University respondents. It has been also found that there is no significant difference in the information literacy skills of the students of both the Universities. Mizoram University students preferred ‘author-wise’ i.e. (59.32 %) search while Tezpur University students preferred ‘title-wise’ i.e. (39.38 %) search technique for searching the information. It has been also found that a maximum respondents of both universities i.e. (MZU, 55.97 %) and (TZU, 54.75 %) preferred the simple keyword search technique to search the electronic information. The maximum students of both universities were preferred print media for fulfil their needed information. In both of the Universities’ respondents were aware with fair use of information and plagiarism with 79.09 per cent of students at MZU and 84.5 per cent of students at TZU. The maximum 39.16 per cent of students were mostly given the references at MZU while in TZU, a large number 57.53 per cent of students were always giving references when they reproduce other work or ideas. Based on a two-sample t-test, as p<0.05, it was found that no significant difference in the information literacy skills of the students of both the Universities. After testing with Scheffe’s test, it has been shown that the mean of the satisfaction level of respondents was significantly different (P <.05) as the absolute value of the calculated t is smaller than the critical value (0.0737<2.201), which shows that there is no significant difference in the satisfaction level of students of both the Universities towards their library orientation program on the use of library resources and services.
Scientific journalism and journalistic profile as methodological elements forthe construction of hypermedia stories
Authors: Urrego Zuluaga Carlos Andrés
Published: September 2021

Este artículo aborda las experiencias, metodología y aprendizajes resultantes del proyecto de investigación-creación Periodismo interactivo. Historias de investigadores en el Eje Cafetero, financiado por la Universidad de Manizales y en alianza con la Fundación Academia de Dibujo Profesional de Cali. Esta iniciativa se centró en tres elementos: una base del periodismo científico y dos columnas: el perfil como género periodístico y la hipermedialidad como canal. Luego de escoger dos historias de científicos con relevantes logros e impactos, se aplicaron los elementos del perfil como género periodístico para construir historias basadas en las experiencias, fuentes, datos y percepciones del equipo de trabajo. Igualmente se cuentan los hitos científicos con las herramientas del periodismo científico para valorar dichos impactos y transcodificarlos para audiencias no especializadas y, finalmente, se eligieron momentos, intervenciones e información relevante para construir una propuesta hipermedial que acompañará el libro que recoge ambas historias.
Integral Citizen Observatory (ICO) Los Cabos: a new citizen participation organization for governing the common good
Authors: Ostos Mota Gloria
Published: September 2021

Desde una aproximación neoinstitucionalista presentamos el OCI Los Cabos como una nueva organización para la participación ciudadana; según la clasificación de North, es un nuevo cuerpo político, que enfrentando los mismos retos para su autogobierno que Ostrom define para otras organizaciones en El Gobierno de los Bienes Comunes, propone además una nueva institución, el estándar internacional ISO 18091, para la gestión de calidad de los gobiernos locales, con el objetivo de promover la eficiencia y la participación ciudadana en el gobierno del bien común local, y global, según la Agenda 2030. En esta interacción compleja entre organizaciones (OCI Los Cabos) y organismos (gobierno local) con las viejas y nuevas instituciones se requiere de una participación ciudadana consciente y competente que desarrollando una inteligencia política colectiva contribuirá, sin duda, a un cambio institucional hacia una mejor gobernanza local global.
Conceptions and teaching practices in a Higher Education Teacher ́s group: Didactic complexities inthe appropriation of the institutional pedagogical model
Authors: García Mora Lewis Herney
Published: September 2021

El artículo tiene por objetivo presentar las reflexiones sobre las concepciones y prácticas pedagógicas implementadas por los docentes en el marco del modelo educativo pedagógico institucional y resaltar algunos retos asociados a la formación pedagógica de estos. Se propuso un enfoque interpretativo que analiza las narrativas didácticas de un grupo de 15 docentes de diferentes programas académicos de una universidad con acreditación multicampus en Colombia. Los resultados muestran que la formación docente constituye un aspecto determinante para el logro de los propósitos institucionales (bucle de autorregulación), así como una estrategia que favorece la emergencia de innovación en docencia (bucle recursivo). Concluye que la formación docente es definitiva para el desarrollo de procesos de diseño, mejoramiento e innovación didáctica en el marco del Modelo Pedagógico Institucional y propone una metodología de formación docente denominada laboratorios didácticos.
Pragmatics of Human Communication50 Years Later
Authors: Bavelas Janet Beavin
Published: September 2021

Pragmatics of Human Communication (1967) was one of the first books on interpersonal communication and became a standard theory book in communication, psychotherapy, and other fields. Face-to-Face Dialogue (in press) by one of the original co-authors presents subsequent decades of research that revealed both similarities and differences; hence, this article. The goals and frame of reference are the same, focusing on interaction rather than on individuals and on dialogic rather than intrapsychic processes. However, advances in theory and research have modified the explicitly tentative axioms of the original book. Examples of these are: (i) theoretical refinement and microanalysis have rejected “all behavior is communication” in favor of a more precise, less inferential focus on co-speech gestures; (ii) “one cannot not communicate” has fared better; the situational context that leads to “disqualification” (equivocation) has strong support; and (iii) the synchrony of digital and analogic elements in dialogue produces integrated messages rather than separate channels.
“A Dress of Fire”: Reading Sándor Ferenczi's Clinical Diary
Authors: Gaitini Mariana
Published: September 2021

Ferenczi's Clinical Diary reveals an exceptional analyst who honestly and bravely documented radical clinical experiences and theoretical insights about the tragic impacts of trauma. The author follows Ferenczi's thinking from his falling out with Freud and his view of the classical psychoanalyst's objectivity and emotional detachment as triggers of the original trauma, through the use of the countertransference to lay bare trauma, eventually issuing in his radical experiment in mutual analysis. The Diary's fate in the history of psychoanalysis reflects that of its thinking on trauma: Beginning with Ferenczi's decades-long silencing and exclusion from the main psychoanalytic community, together with the silencing of actual trauma, this history evolved into the revival and dissemination of Ferenczi's thinking and the reappraisal of the role of actual trauma.
Stop AAPI Hate National Report
Authors: Jeung Russell , Horse Aggie Yellow , Popovic Tara , Lim Richard
Published: September 2021

This report offers aggregated national data and some selected personal testimonials about Asian American experiences with anti-Asian violence. The data is presented by types of discrimination and violence experienced, the ethnic breakdown of those being targeted, and the locations where Asian Americans were targeted.
Fostering Gender Equality in the Arab Region is Non-Negotiable
Authors: Abirafeh Lina
Published: September 2021

Lina Abirafeh describes the global conditions of gender equality and violence against women. She offers a brief history of her work to prevent violence against women and to build a better world for women. The author outlines the current promises and challenges for women’s equality in the Arab states, and the role of the Arab Institute for Women in realizing those promises and overcoming the challenges. She ends with a call for support of feminist activists and gender equality-focused organizations, including the Arab Institute for Women.
The Italian Leadership on Inclusive Education: Myth or Reality?
Authors: Marsili Francesco , Morganti Annalisa , Signorelli Alessia
Published: September 2021

Abstract: Background: Italy is internationally known as a Country with a longstanding “tradition” of inclusive education.
Objective: Aim of the paper is to provide a frame on the educational policies that, since 1970s, have steered the school system according to a “fully inclusive” model, highlighting the instruments of teaching – learning and evaluation tools for assessing the quality of the inclusive processes.
Methodology: Starting from primary and secondary legislative sources, the paper identifies three main focus points: the passage from the inclusive “principle” to the teaching – learning practices; the tools for answering special educational needs; the tools for assessing the quality of inclusive processes.
Discussion: Even though there are many efforts to align to international legislative regulations and to modernize the concept of inclusive education, Italian reality seems to be ossified in self-referential attitudes, beliefs and practices that saturate the school system. The paper outlines the need for defining new systemic research approaches that can validate this long educational tradition.