bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGI PENGAWASAN APARATUR SIPIL NEGARA DI KABUPATEN ACEH BARAT
Authors: Juseprita Nike
Published: July 2023

This research is about the ASN supervisory strategy by the West Aceh District BKPSDM. strategy is an idea that is arranged before carrying out an action or action in doing something so that what is the goal can be achieved. So that the results achieved are maximized and efficient before taking an action there must be a strategy used. This study aims to see how far the strategy has been carried out by BKPSDM towards ASN. This research uses qualitative research methods and data collection is carried out through interviews, observation, and documentation. the results of the study show that the supervision strategy is good enough, supervision is carried out through online attendance. However, there are still obstacles such as the lack of maximum supervision carried out due to a lack of BKPSDM personnel in supervising ASN which exceeds the number of BKPSDM. The conclusion from this research is that the supervision strategy has been going well. but there are inhibiting aspects such as the lack of BKPSDM personnel in supervision.
DIGITAL: FENOMENA PROSTITUSI ONLINE DI DAERAH PENERAPAN SYARI’AT ISLAM
Authors: Fanzikri Mirza , Nur Zalikha Siti , Hamdani Tri Mairina , Sonia Sonia
Published: July 2023

Digital developments, expected to contribute to efficiency and ease in the development process, are often used reversely. Specific communities also use digital technology as a means of communication and information in carrying out practices that violate norms and laws. In Aceh Province, which incidentally is the implementation area of Islamic Shari'at, the use of digital is used in practices that violate the Qanun (regional regulation) of Islamic Shari'at. Prostitution, one of the criminal cases of Islamic Sharia, was found that all perpetrators revealed that they carried out these 'unlawful' transactions through online media. This study aims to explain the driving factors for prostitution behavior and explain the government's collaborative efforts in dealing with online prostitution in Aceh. This study uses a qualitative approach that descriptively describes the primary and secondary data. Preliminary data were obtained through interviews and observation techniques, while secondary data was obtained through document review. Data analysis was passed through classification, reduction, and conclusion. The study results show that the driving factor for the dominant prostitution behavior is motivated by personal desires. In addition, it is also caused by environmental and lifestyle factors, the economy, family problems, as well as experiences of sexual harassment, and the loss of virginity. The government's collaborative efforts in dealing with online prostitution are carried out by controlling prostitution. The government and other elements of society conduct routine raids and patrols and hold outreach to the community down to the community level.
Kognisi Taksonomi Bloom, Kurikulum 2013 dan Penerapannya dalam Pembelajaran Agama Islam di Indonesia
Authors: Muhammad Ismail , Ariani Safrina
Published: July 2023

The use of Bloom Cognitive Taxonomy started since the launching of the book: The Taxonomy of Education Objectives, The Clasification of Educational Goals, Handbook I: Cognitive Domain, published by Longman in the year 1956. The Taxonomy then has been developed by Peter W. Airasian and his friends in their book: A Taxonomi for Learning, Teaching, and Assesing: A Revision of Bloom’s Taxonomy of Educational Objectivesm, A Bridget Edition, edited by W. Anderson and David R. Krathwohl, and published by Addison Wesley Longman, Inc, in 2001. The substantial change of development between the two books is: a) the development of main words from its verb source, b). Bloom separate between the ability of ‘to analyze’ and ‘to synthesize’, while Airasian et.al unites them and put as the 5th cognitive ability, then they propose the ability ‘to create’ as the 6th cognitive ability. The applicative usage of Bloom Cognitive Taxonomy and its revision can be applied fully in the teaching Islamic material, nevertheless, it requires teachers the ability to understand the taxonomy concepts comprehensively and the curriculum applied and the ability to develop and expand main objectives to indicators of instructional activities.
PERKEMBANGAN FITRAH RELIGIUSITAS MANUSIA DALAM PERSPEKTIF PENDIDIKAN ISLAM
Authors: Amin Askur , Rinaldi Rahmad
Published: July 2023

This study aims to understand how school principals can carry out their leadership according to procedures, and try to explain how school principals in carrying out their leadership are able to move teachers, students, and school residents to always improve the quality of education at MTs Al-Ulum Medan. Things that are observed by related researchers; 1) How is the implementation of the principal's leadership in carrying out its function to improve the quality of the school, 2) What is the role of the principal's leadership in dealing with obstacles in carrying out his duties. For this reason, researchers are interested in conducting research on "Leadership of Principals in Improving the Quality of Education at MTs Al-Ulum Medan.
Manajemen Stess dalam Pendidikan Islam
Authors: AlFadhil Musa
Published: July 2023

This study describes the character of being responsible for students through the internalization of the concept of independent learning. This research is qualitative research with content analysis. The data comes from books, journals, and articles that discuss the character of responsibility. Based on the studies that have been done, the character of responsibility includes aspects of the world and the hereafter. In the spiritual dimension, the character of responsibility becomes the spiritual basis for the relationship between faith and human behavior.
Efektivitas Komunikasi Interpersonal Kepala Sekolah dalam Meningkatkan Kinerja Guru
Authors: Nurasiah Nurasiah , Zulkhairi Zulkhairi
Published: July 2023

This study aims to obtain information about the process and effectiveness of interpersonal communication principles in improving performance at Lhokseumawe 2 Public Middle School. The method used in this study is a qualitative method with a descriptive approach. The research data source consisted of principals, administration section, parts and infrastructure, and teachers. Data collection techniques through interviews, observation, and documentation. Data analysis uses data collection, data reduction, data presentation, and drawing conclusions or data verification. The results showed that the process of interpersonal communication in improving the performance of the teacher applied, there were two communication perspectives used namely psychological and mechanical. And use two types of verbal and nonverbal communication, both types of communication are used based on the needs that occur in the field. Regarding the effectiveness of interpersonal communication in increasing teacher performance, to obtain effective communication, there are several interpersonal communication indicators used, namely: openness, empathy, support, positive behavior, and similarities.
RELIGIUSITAS DAN SEKSUALITAS REMAJA PERKOTAAN: STUDI TENTANG PERILAKU PELAJAR KOTA LHOKSEUMAWE, ACEH
Authors: Fikri Mumtazul
Published: July 2023

This study concludes that the religiosity and sexuality of students in the city of Lhokseumawe are good. The conclusion of this study is different from the publication which states that the free sex of students in the city of Lhokseumawe is the first rank in Aceh. This study aims to find information about the religiosity and sexuality of Lhokseumawe city students, the causes of sexual behavior deviations from Lhokseumawe city students, and the Lhokseumawe city government's solution to stem the deviant sexual behavior of students. This research is a case study research, where data collection is done through in-depth interviews, documentation, and observation. The results showed that, firstly, the religiosity of students was classified as good as evidenced by the pattern of Islamic school uniforms, attitudes and verbal behavior were generally good although some still needed guidance. Attitude and verbal behavior are strongly influenced by domicile origin, economic strata, and parental education. Second, student sexuality is also classified as good as evidenced by the absence of evidence of free sex among students, opposite-sex relationships are still within reasonable limits, although they still require guidance. The sexuality of students at school is strongly influenced by the care of parents in the family. Third, the researchers did not find evidence of free sex in Lhokseumawe city students, but deviations in verbal behavior in the form of pornographic remarks were still found. This behavior is strongly influenced by the socio-cultural area of origin, economic strata, and parental education. Fourth, the solution of the Lhokseumawe city government in stemming student sexual behavior deviations is divided into 3 levels. (1) at the regional level, sterilizing areas have the potential for lewdness, such as the mobile reservoir area, KP3, and Krueng Cunda. (2) the gampong level, by optimizing the potential for religiosities, such as religious tactical funds of 2 million per village, and umrah rewards for the teungku. (3) school level, with religious programs, such as congregational dhuhur prayers, regular Friday taushiah, Ramadan Islamic boarding schools, and al-Qur'an reading programs.
Persepsi Perempuan Bireuen terhadap Rancangan Qanun Poligami di Aceh (Analisis Menurut Teori Self Perception)
Authors: Khaliluddin Syeh
Published: July 2023

This research was conducted in Bireuen Regency, Aceh in 2021 using a qualitative descriptive method based on field research using a self-perception theory approach. This theory serves to analyze how women's perceptions regarding the draft qanun on family law in Aceh regarding polygamy were initiated by the Aceh provincial government through the Islamic Shari'a Service and discussed at the legislative level in August 2019. The number of informants in this study was 100 women who were taken as samples. in 6 sub-districts out of 17 sub-districts in Bireuen Regency. Informants were classified into three social classes consisting of religious, bureaucrats, and business people. The results show that negative perceptions of polygamy regulation are influenced by empirical stimuli and negative stigma in society, where polygamy is attributed as a betrayal and male domination in the household. However, after knowing the substance of the qanun, their perception drastically changed. 60% of informants agree because they perceive that the draft qanun is a regional regulation that can strengthen the existing law on polygamy. Meanwhile, 40% of informants perceive that the draft qanun can motivate a husband to polygamy and the decision of the Sharia Court to give permission for polygamy to the husband if the wife is sick. 5% of informants are antipathy to any issues, even regulations regarding polygamy.
Penguatan Kearifan Lokal dalam Pembelajaran melalui Pengembangan Bahan Ajar Pendidikan Agama Islam
Authors: Riza Syahrul
Published: July 2023

This article examines the strengthening of local wisdom in learning Islamic Religious Education in schools. This research leads to the development of PAI teaching materials associated with local wisdom. The purpose of this research is to find and research about PAI teaching materials that are applied by juxtaposing or linking them with local wisdom. In the process, this research does not direct the learning of Islamic Religious Education in the qualitative and quantitative domains or in combination, but this learning can use one or even both in its learning methodology. This study discusses the application of learning that leads to the development of PAI teaching materials by looking at Islamic values and local wisdom. This can be referred to as the result of observing habits that are taught and practiced in the learning process activities at school.
Fungsi Metode terhadap Pencapaian Tujuan dalam Komponen Pembelajaran
Authors: Bararah Isnawardatul
Published: July 2023

Internal and external factors are factors that influence students in learning achievement. Among the internal factors that can be internalized by students in learning, achievement includes attitudes towards learning, interest, and motivation to learn, concentration in learning, in addition, there are also external factors which include: teachers as coaches in the learning process, learning infrastructure and facilities, assessment, environment social welfare of students both at school and at home as well as the curriculum applied at school. The stage of learning achievement will be easily achieved if a teacher is wise in determining the use of learning methods. These conditions will affect student achievement in responding to each component of the learning material taught by the teacher for all subjects. Although not all teachers use the same learning method approach, on the other hand, a teacher is also required to master complex learning materials so that the transfer of knowledge process in the classroom represents all learning materials as a whole.
Analisis Peningkatan Mutu Pendidikan melalui Penggunaan Literasi Digital pada Madrasah Aliyah Negeri di Provinsi Aceh
Authors: Amiruddin Amiruddin , Azhari Azhari
Published: July 2023

The obligations of teachers in Madrasahs are complex. The Ministry of Religion of Aceh Province as the protector of teachers who work in Madrasahs has provided various trainings for teachers. One of them is the collaboration between the Ministry of Religion of Aceh Province and USAID PRIORITAS in a number of Madrasahs in Aceh. Based on these activities, it turns out that they are still unable to provide accurate answers about Madrasahs in Aceh Province. Where many cannot be studied in depth about professional development for all teachers in the Ministry of Religion of Aceh Province. Every educational institution must have infrastructure. The infrastructure that is directly related to teaching is the classroom. These basic facilities are one of the media to carry out Madrasah functions. The study room is a space for theoretical and practical learning that does not require special equipment. Classroom management is a prerequisite as well as the most important aspect in realizing effective learning. This is done to refer to the creation of an atmosphere or class condition that allows students to carry out the learning process effectively and pleasantly. So that the integration between digital literacy and the need for materials and teaching materials has not been fully able to meet the sources and teaching materials at Madrasah Aliyah, this condition is related to the readiness of expertise for educators in producing digital literacy innovations that can be adapted to teaching materials and materials based on the applicable curriculum. The use of digital literacy has an influence on the analysis of the quality of madrasa education. Institutional regression results have an effect of 14.3% and madrasah have an influence of 66.2%.
AJARAN TAUHID ITU PENTING
Authors: Siregar Fajariski Wahyudi , Halimah Siti , Halimah Siti , Ahkas Akmal Walad , Ahkas Akmal Walad
Published: July 2023

This study aims to determine and describe: (1) the effect of implementing learning strategies on the learning outcomes of Qur'an Hadith students at Madrasah Tsanawiyah Darul Aman Medan, (2) the effect of interest in learning on learning outcomes of Qur'an Hadith students at Madrasah Tsanawiyah Darul Aman Medan and (3) the interaction between learning strategies and interest in learning on the learning outcomes of the Qur'an Hadith students of Madrasah Tsanawiyah Darul Aman Medan. The method used in this research is a quasi-experimental method. The research population was all students of class VIII Madrasah Tsanawiyah Darul Aman Medan, which consisted of 4 classes. The results of the study indicate that: (1) There is an influence of learning strategies on the learning outcomes of the Qur'an Hadith students of MTs Darul Aman Medan. by obtaining the value of Fcount (34.20) > Ftable (3.97) with dk (1.72) and the level of significance = 0.05. (2) There is an influence of interest in learning on the learning outcomes of the Qur'an Hadith students of MTs Darul Aman Medan, by obtaining a value of Fcount (4.16) > Ftable (3.97) with dk (1.72) and the real level = 0.05. (3) There is an interaction between learning strategies and interest in learning. This is evidenced by statistical tests that Fcount (10.02) > Ftable (3.97) with dk (1.72) and the level of significance = 0.05
Fenomena LGBTQ+: Analisis Fitrah Seksualitas Manusia
Authors: Suraiya Suraiya
Published: July 2023

LGBTQ+ is a sexual deviance that is rampant in society these days. Some people consider that this sexual disorder is caused by hereditary or genetic factors, but studies have proven that this phenomenon is caused by mis-parenting and environmental factors. In the context of Islamic Education, this sexual perversion is caused by the injury of sexual fitrah. In addition, this disorder is also caused by social factors, culture or bad lifestyle. Islam has taught how to grow the fitrah of sexuality through several stages; starting from the age of 0-2 years, 2-7 years, 7-10 years, 10-14 years to the aqil period of baliqh. The presence of a masculine father figure and a feminine mother who accompanies and educates children according to gender from the time they are born to aqil baligh is the key to the child growing according to the fitrah based on his sexuality. If this phase of caring for sexuality is missed, then the seeds of perversion will grow and strengthen. The efforts to cultivate the fitrah of child sexuality must also be combined with instilling the fitrah of faith since both are the keys, so that the child grows completely according to the will of his God when he is presented to this world. Another very important effort is to pay attention to the child's social environment because association might affect our children’s way of thinking and lifestyle.
Cyber Counseling: Definisi, Layanan, Pase dan Model
Authors: Muslima Muslima
Published: July 2023

This article aims to provide information about advances in information and communication technology, the number of Internet users is increasing rapidly. Almost everyone in the world uses the internet in their daily life. Technological developments also affect the implementation of guidance and counseling services, especially in schools. In the era of globalization, there is a great demand for online counseling and cyber counseling by counselors and counseling teachers who can provide services regardless of distance and time. According to the survey results, cyber counseling services are considered effective because they provide opportunities for counselors and students to provide counseling that is not limited by distance and time. There are several stages of cyber counseling services used by counselors. Various models are used to conduct online consultations, including email, Facebook, asynchronous chat, riliv applications, video conferencing, mobile phones, and websites. Supervisors and counselors are expected to continue to improve their abilities in utilizing information and communication technology.
STRATEGI IMPLEMENTASI PENDEKATAN SCIENTIVIC PADA PEMBELAJARAN Al-QUR’AN HADIS UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KRITIS DAN SIKAP ILMIAH SISWA MAN DI PROVINSI ACEH
Authors: Uce Loeziana
Published: July 2023

The phenomenon of adolescent promiscuity is already in an alarming position. The behavior of teenage couples showing affection in public places is very easy to find, including on the streets, dimly lit "keude kupi" or in other entertainment venues. Such behavior when prosecution is carried out will be faced by human rights activists. As an Eastern nation known for its strong religious values, premarital sex is a disgrace that must be prevented. Initial predictions that premarital sex that occurs among adolescents cannot be separated from the influence of pornographic videos and various information about pornography which are very easily accessible from the internet, so that information about sex must be provided in a manner and guidance that is in accordance with eastern customs, built with shame and ibda ' binafsih. This study specifically explains the efforts of the family as an institution that has special authority in children's education. Meanwhile, there is very little information about sex education with actual or Islamic principles of decency and it has even become taboo to talk about in society. Observing this phenomenon where in the midst of an information battle that leads to freedom of values, parents with the support of society and the government must work together to provide understanding to children about the dangers of free sex. Provide healthy sex information to children, starting from the family to the management of healthy social media by the government as their responsibility. The solution in the form of implementing Islamic sex education in family institutions is expected to provide useful and soothing information for adolescents who are euphoric about getting information about sexual issues.
Penerapan Problem Based Learning dalam Pendidikan Agama Islam
Authors: Suraiya Suraiya
Published: July 2023

Educators should choose a learning model that can generate students’ enthusiasm for learning and develop their potential so that they are able to solve the problems faced in life. Problem Based Learning is one of  learning models that is considered can maximize the students’ potential and guide them to have the ability to solve problems in life. Problem Based Learning (PBL) is based on constructivism and accommodates students' involvement in the learning process and problem solving. To apply PBL in the learning process, there are several principles and procedures that must be understood by educators. To implement PBL in the learning process, educators should follow the procedures or implementation stages. The procedure for implementing PBL is divided into several steps, namely: problem orientation, organizing students to study (in groups), investigation or data collection, developing and presenting work results and finally; evaluation and reflection. This PBL model certainly has advantages and disadvantages, so educators should study all things related to this PBL to maximize results and minimize deficiencies, educators should adhere to the principles and procedures for implementing them in the learning process because PBL is one of the learning models that is capable to answer the needs of students and be relevant to the demands of this century.
Principales patologías diagnosticadas por el servicio de Neurología en urgencias e internación en un hospital universitario en Colombia 2020 - 2021
Authors: Bustos Sánchez José Luis , Jurado López Sandra Patricia , Aroca Posso Alexander , Márquez Rosales Benjamín Alexander , Alonso Niño Mónica Alexandra , Hoyos Gómez Laura Katherine , Oyola Rojas Alba Gineth , Ortiz Losada Eliana Yulitza , Niño Ortiz Marianella , Novoa Quiñones Valentina , Fernández-Ávila Daniel Gerardo
Published: July 2023

INTRODUCCIÓN:
Las enfermedades neurológicas constituyen gran parte de las urgencias médicas (10 %-15%). Por ende, se hace necesario el reconocimiento de la distribución de las principales condiciones tanto en urgencias como en hospitalización. Se decidió caracterizar la distribución real de la enfermedad neurológica atendida en un hospital universitario de tercer nivel en Boyacá.

MATERIALES Y MÉTODOS:
Estudio descriptivo de corte transversal.

RESULTADOS:
1203 pacientes con edad promedio de 56,2 (± 21,2) años, la mayoría de sexo masculino, casi la mitad de ellos nivel de educación básica primaria. De un total de 81 diagnósticos, se caracterizaron clínica y sociodemográficamente los 12 primeros, encontrando que en el área de urgencias prevalece la enfermedad cerebrovascular, epilepsia, cefalea, polineuropatia y vértigo.

CONCLUSIONES.
Los principales motivos de interconsulta del servicio son la enfermedad cerebrovascular y el delirio en urgencias e internación respectivamente, siendo generadas principalmente por medicina general, medicina interna y unidad de cuidado intensivo.
Plaguicidas de bajo impacto ambiental en el control de la cochinilla de la nieve Aulacaspis tubercularis Newstead (Hemiptera: Diaspididae) del mango en Perú
Authors: Valverde- Rodríguez Agustina , Ramos-Vega Yaneth Isabel , Campos Albornoz Miltao Edelio , Jara Claudio Fleli Ricardo
Published: July 2023

Introducción. Los factores medioambientales predominantes en los valles interandinos y la región costera de Perú han favorecido el incremento de las producciones y las exportaciones del mango (Mangifera indica L.) a más de treinta países en los dos últimos años, en este proceso el respaldo fitosanitario ha sido y lo seguirá siendo de suma importancia, sin embargo, la presencia de la especie Aulacaspis tubercularis —plaga invasora del cultivo— es un factor limitante sin importar la variedad del cultivo. Su control es con insecticidas de amplio espectro que contaminan y degradan al ambiente y no se tiene información del control exitoso. Objetivo. Se determinó la efectividad de plaguicidas de bajo impacto ambiental en la incidencia y mortalidad de la especie A. tubercularis. Materiales y métodos. Los productos evaluados fueron el detergente comercial, el aceite mineral, la azadiractina, y el jabón potásico. En campo, asperjados al cultivo con una frecuencia de cada siete días, en laboratorio, sobre los individuos colonia en frasco. Resultados. Se reveló que los cuatro productos evaluados redujeron significativamente las colonias en campo y mostraron eficacias de hasta 95 %, 89 %, 77 % y 68 % respectivamente durante los tres primeros momentos de aplicación. En condiciones de laboratorio el tratamiento detergente comercial y la azadiractina ejercieron el mayor control (100 %) en cuatro días de evaluación. Conclusiones. Los productos ensayados ofrecen una buena alternativa para el control de la escama blanca en los cultivos de mango.
Impactos ambientales y operativos al instalar válvulas de compensación de aire en tractocamiones en Colombia
Authors: Prieto-Rodríguez Germán , Cabrera-Moya Diego , Estupiñán Salomón
Published: July 2023

Introducción. Las válvulas de compensación de aire son dispositivos que buscan optimizar el rendimiento y reducir las emisiones contaminantes de los motores diesel de vehículos de carga en condiciones de alta montaña, al compensar el oxígeno que se pierde cuando un vehículo opera a plena carga y en alturas que sobrepasan los 2.000 msnm, condiciones que se presentan con frecuencia en países del área Andina. Sin embargo, no se conocen estudios que cuantifiquen el impacto efectivo de estos dispositivos en una operación real en el territorio colombiano. Objetivo. Se analizaron cambios en el consumo de combustibles y generación de emisiones contaminantes instalando válvulas ecológicas en una flota de tres vehículos tractocamión operados por una empresa generadora de carga en una ruta en Colombia. Materiales y métodos. Se aplicó un estudio experimental, determinando la relación entre la instalación de la válvula ecológica Marclais M-300 en tres vehículos de carga similares, realizando mediciones ex ante y ex post bajo condiciones controladas de ruta y conductores. Resultados. La instalación de la válvula no generó una disminución representativa de los galones consumidos y, por tanto, tampoco una disminución en los costos de operación. Se encontró una disminución de emisiones contaminantes de 6,25 % y las muestras de aceite no reportan ningún daño mecánico generado por el uso de las válvulas. Conclusiones. Se recomienda ampliar la muestra y realizar análisis comparativos con otro tipo de válvulas o complementos con propuestas de valor similares, incluyendo un análisis de eficiencia en los costos de inversión.
Tecnologías Limpias de Producción Agrícola: Aliadas en La Búsqueda de la Seguridad Alimentaria en el Valle de Aburrá
Authors: Pantoja Guerra Manuel
Published: July 2023

La consecución de la seguridad alimentaria constituye uno de los principales retos para la humanidad en el siglo XXI. En ese sentido, la Organización de las Naciones Unidas estableció la estrategia “hambre cero” como uno de los 17 objetivos del desarrollo sostenible hasta 20302. Según esta entidad, 690 millones de personas padecieron hambre en el año 2020, de los cuales, 47.7 millones estaban en Latinoamérica y el Caribe; además, se estima que 840 millones de personas padecerán hambre en 2030.
violencia y la mujer en la prensa, un análisis desde la teoría de género y el framing
Authors: Trejos Escobar Valentina
Published: July 2023

Este estudio analiza y categoriza los tipos de frames que brinda el periódico La Patria en las noticias relacionadas con la violencia contra la mujer durante el año 2021. Para el presente caso se realizó una investigación de naturaleza cuantitativa de 186 noticias, en donde se establecieron hipótesis y se determinaron como unidades de análisis palabras clave, referencias, descripciones y estructuras semánticas. En esta investigación se encontraron como resultados principales la visibilidad e importancia informativa que se da a la violencia contra la mujer, la connotación negativa y poco reflexiva de las noticias, la interacción entre violencia, derechos y marcos conceptuales repetitivos como representación desfavorable de la mujer en la prensa y los frames construidos principalmente desde el propósito meramente informativo, expositivo y poco controversial de la violencia contra la mujer en el Periódico La patria.
Integrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE-mediated pediatric cow's milk allergy
Authors: Vanhaecke Lynn , Paepe Ellen De , Plekhova Vera , Vangeenderhuysen Pablo , Baeck Nele , MA Dominique Bullens , Claeys Tania , Graeve Marilyn De , Kamoen Kristien , Notebaert Anneleen , Wiele Tom Van de , Broeck Wim Van Den , Vanlede Koen , Winckel Myriam Van , Vereecke Lars , Elliott Chris , Cox Eric
Published: July 2023

Background: IgE-mediated cow’s milk allergy (IgE-CMA) is one of the
first allergies to arise in early childhood and may result from exposure
to various milk allergens, of which β-lactoglobulin (BLG) and casein are
the most important. Understanding the underlying mechanisms behind
IgE-CMA is imperative for the discovery of novel biomarkers and the
design of innovative treatment and prevention strategies. Methods: We
report a longitudinal in vivo murine model, in which 2 mice
strains (BALB/c and C57Bl/6) were sensitized to BLG using either cholera
toxin or an oil emulsion (n=6 per group). After sensitization, mice were
challenged orally, their clinical signs monitored, antibody (IgE and
IgG1) and cytokine levels (IL-4 and IFN-γ) measured, and fecal samples
subjected to metabolomics. The results of the murine models were further
supported by fecal microbiome-metabolome data from our population of
IgE-CMA (n=24) and healthy (n=23) children (Trial: NCT04249973), on
which polar metabolomics, lipidomics and 16S rRNA metasequencing were
performed. In vitro gastrointestinal digestions and multi-omics
corroborated the microbial origin of proposed metabolic changes.
Results: During sensitization, we observed multiple microbially derived
metabolic alterations, most importantly bile acid, energy and tryptophan
metabolites, that preceded allergic inflammation. The latter was
reflected in a disturbed sphingolipid metabolism. We confirmed microbial
dysbiosis, and its causal effect on metabolic alterations in our patient
cohort, which was accompanied by metabolic signatures of low-grade
inflammation. Conclusion: Our results indicate that gut dysbiosis
precedes allergic inflammation and nurtures a chronic low-grade
inflammation in children on elimination diets, opening important new
opportunities for future prevention and treatment strategies.
Effect of increasing concentrations of NaCl on Saharan cypress Cupressus dupreziana A. Camus: Tolerance and adaptive responses to salt stress
Authors: GUELLABI NIHAL , degaichia hoceme , benrima atika , boussahoua ahmed-ramzi
Published: July 2023

The analysis of variations in growth, relative water content, proline
and soluble sugars were analyzed to study the behavior of Cupressus
dupreziana under salt stress stability at the level of relative water
content, proline content and soluble sugars during the treatment of
plants with 50 mmol (mM) of NaCl indicates that this level of salinity
does not disturb the physiology of the plant whereas decreases in
relative water content and growth rate suggest that high salt
concentrations (200, 350, 500 mM) cause disturbances in plant
physiology, while increases in compatible solutes improve salt tolerance
Our results contribute to the preliminary knowledge of salt acclimation
in Cupressus dupreziana.
Hybrid Coupler used as tunable phase shifter based on varactor diodes
Authors: Benaouf Taleb mohamed , Hamdoun Abdelaziz , Himdi mohamed , Lafond Olivier , AMMOR Hassan
Published: July 2023

This paper describes the design of a hybrid coupler with a continuously
variable output phase difference. This is achieved by using
reconfigurable transmission lines with electrically tunable lengths
controlled by two biasing voltages through varactor diodes placed across
the coupler branches. The design of the coupler is based on the
quadrature hybrid structure for the case where the output phase
difference is 90° and on the asymmetric structure for the other cases.
The proposed coupler can achieve a tunable output phase difference from
52 to 128 while keeping a coupling coefficient of -3dB (± 0.5dB) over
the entire desired frequency band. To validate the simulated results, a
prototype working at 3.5 GHz was fabricated and tested. The measurement
results show good correspondence with the simulation results, especially
when the output phase difference is 90° while a phase mismatch of less
than 7° was observed for the other cases. The presented coupler would be
a great asset for antenna feeding arrays, especially the Butler matrix.
Factors Influencing The Attitudes Of Secondary School Students Towards The Study Of Mathematics.
Authors: Olayinka Adesola Afolayan , OLAYINKA JANET OYERONKE
Published: July 2023

It is a known fact that there exist behavioral difficulties among
Mathematics students in Estiwani as a result of unresolved attitudinal
issues that either the students are not aware of, or that the issues are
not properly dealt with. This work seeks to investigate some factors
influencing the attitude of secondary school students toward studying
Mathematics in the Mazini region. Five schools consisting of two
boys-only, two girls-only, and one mixed school were been carefully
selected for the investigation. A total of 200 students and 15 qualified
teachers were randomly and actively engaged. A combination of the
discrete and continuous data collected through observations and using a
well-designed questionnaire was carefully analyzed from their graphical
representations. It was found that the majority of the students showed a
huge gap in the content knowledge and also presented a clear negative
attitude towards Mathematics as a subject. Some of the factors
responsible for this worrying pattern, as shown by the analysis include
poor background from their primary schools, ineffective teaching methods
by their teachers, and lack of motivation by their parents among others.
Training programs for teachers particularly on the use of technology and
teaching aids to better disseminate the contents and the rewards were
also highlighted
Quantifying the probability of a successful marine bioinvasion due to source-destination risk factors
Authors: Tzeng Mimi , Floerl Lisa , Schattschneider Jessica , Floerl Oliver , Jeffs A , Zaiko Anastasija
Published: July 2023

The increasing spread of marine non-indigenous species (NIS) due to the
growth in global shipping traffic is causing widespread concern for the
ecological and economic impacts of marine bioinvasions. Risk management
authorities need tools to identify pathways and source regions of
priority concern in order to better target efforts for preventing NIS
introduction. The probability of a successful NIS introduction is
affected by the probability that a marine species entrained in a
transport vector will survive the voyage between origin and destination
locations, and establish an independently reproducing population at the
destination. Three important risk factors are voyage duration, range of
environmental conditions encountered during transit, and environmental
similarity between origin and destination. In this study, we aimed for a
globally comprehensive approach of assembling quantifications of
source-destination risk factors from every potential origin to every
potential destination. To derive estimates of voyage-related marine
biosecurity risk, we used computer-simulated vessel paths between pairs
of ecoprovinces in the Marine Ecoregions Of the World biogeographic
classification system. We used the physical length of each path to
calculate voyage duration risk, and the cross-latitudinal extent of the
path to calculate voyage path risk. Environmental similarity risk was
based on comparing annual average sea surface temperature and salinity
within each ecoprovince to those of other ecoprovinces. We derived three
separate sets of risk quantifications, one each for voyage duration,
voyage path, and environmental similarity. Our quantifications can be
applied to studies that require source-destination risk estimates. They
can be used separately or combined, depending on the importance of the
types of source-destination risks that might be relevant to particular
scientific or risk management questions or applications.
Non-invasive age estimation based on fecal DNA using methylation-sensitive high-resolution melting for Indo-Pacific bottlenose dolphins
Authors: Yagi Genfu , Qi Huiyuan , Arai Kana , Kita Yuki F. , Kogi Kazunobu , Morisaka Tadamichi , Yoshioka Motoi , Inoue-Murayama Miho
Published: July 2023

Age is necessary information for the study of life history of wild
animals. A general method to estimate the age of odontocetes is counting
dental growth layer groups (GLGs). However, this method is highly
invasive as it requires the capture and handling of individuals to
collect their teeth. Recently, the development of DNA-based age
estimation methods has been actively studied as an alternative to such
invasive methods, of which many have used biopsy samples. However, if
DNA-based age estimation can be developed from fecal samples, age
estimation can be performed without touching or disrupting individuals,
thus establishing an entirely non-invasive method. We developed an age
estimation model using the methylation rate of two gene regions,
GRIA2 and CDKN2A, measured through methylation-sensitive
high-resolution melting (MS-HRM) from fecal samples of wild Indo-Pacific
bottlenose dolphins (Tursiops aduncus). The age of individuals
was known through conducting longitudinal individual identification
surveys underwater. Methylation rates were quantified from 36 samples.
Both gene regions showed a significant correlation between age and
methylation rate. The age estimation model was constructed based on the
methylation rates of both genes which achieved sufficient accuracy
(after LOOCV: MAE = 5.08, R2 = 0.34) for the ecological studies
of the Indo-Pacific bottlenose dolphins, with a lifespan of 40-50 years.
This is the first study to report the use of non-invasive fecal samples
to estimate the age of marine mammals.
a case report of heterochronic presentation of a bilateral tubal pregnancy
Authors: Mansouri Zeinab , mehdikhani bahare , tarafdari azam , Azizi Sepideh , shababi amirali , davari farzad vaghef
Published: July 2023

Bilateral tubal pregnancy (BTP) is the most uncommon form of tubal
ectopic pregnancy. Complications are associated with maternal morbidity
and mortality. We reported a case with a left tubal pregnancy and
laparascopic salpingostomy was done. During the follow up the
contralateral ectopic pregnancy was discovered and treated with MTX.
Study on Minimum Safety Protection Distance of High-Pressure Natural Gas Pipeline Based on Physical Explosion Injury Consequences
Authors: Liu Yuqing , Zhou Yazhe , Wang Wenshu , Tian Shanshan , Zhou Yawei , Gao Na , Kazman Karyal
Published: July 2023

High-pressure natural gas pipeline transportation has the advantages of
large gas transmission capacity, low transportation cost, whereas
physical explosion of the pipeline may cause casualties and property
losses. Based on the theory of conversion of physical explosion energy
and TNT equivalent of high-pressure natural gas pipeline, this research
uses HyperMesh software to build a physical explosion model of
high-pressure natural gas pipeline. The crater generated by physical
explosion of pipeline was simulated and analyzed using LS-DYNA software.
It can be concluded that the crater building process was completed in
0.038 s, forming spindle shaped cavity crater (9.27 m×4.86 m×3.0 m). The
overpressure value of the shock wave at the center of the ground burst
is 6.64 MPa according to the simulation of the generation and
attenuation process of the physical explosion shock wave. Based on
Sadovsky’s research conclusion on shock wave attenuation, the minimum
distance required for shock wave attenuation on the ground to the safe
overpressure value (0.02 MPa) is 33 m. The research conclusion is of
great significance to the prediction of the consequences of physical
explosion damage of high-pressure natural gas pipeline and the
determination of the safe laying scheme.
Hematopoietic Bone Marrow Transplant to Treat Systemic EBV-positive T-Cell Lymphoma of Childhood
Authors: Manini Nicholas , Davidow Kimberly , Conard Katrina , Powell Jonathan
Published: July 2023

Systemic EBV positive T-cell lymphoma of childhood (S-EBV-TCL) is a rare
disease for which there is no standard of care. S-EBV-TCL is often
associated with hemophagocytic lymphohistiocytosis (HLH) and is
generally thought of on the spectrum of Epstein-Barr Virus (EBV) related
disease. For the few reported cases of cure in the literature,
hematopoietic stem cell transplant (HSCT) has been required. Here, we
present the case of one patient who was successfully cured with a
modified regimen of dose adjusted EPOCH (etoposide, prednisone,
vincristine, cyclophosphamide, doxorubicin), followed by HSCT using a
reduced intensity conditioning regimen.
Peak detection algorithm for mass spectrometry integrating weighted continuous wavelet transform with particle swarm optimization-based Otsu
Authors: Gao Wenqing , Hu Xiangyang , Zhou Junfei , Li Junhui , Zhou Jun , Yu Jiancheng , Tang Keqi
Published: July 2023

Rationale: Peak detection is an important step in mass
spectrometry, accurately identifying characteristic peaks is key to data
analysis. However, the spectrum being analyzed often contains random
noise and baseline variations, which present significant challenges in
the process of peak detection. In order to address the issue of false
peak detection, while simultaneously ensuring accurate detection of weak
and overlapped peaks, this paper introduces an improved algorithm for
mass spectrometry integrating weighted continuous wavelet transform with
particle swarm optimization-based Otsu (WWTPO). Methods: The
algorithm utilizes the Mexican hat wavelet as the mother wavelet and
applies the weighted continuous wavelet transform (WCWT) to compress the
frequency spectrum signal into a smaller scale range, which allows for
the acquisition of more distinct and informative peak information.
Moreover, the algorithm employs the particle swarm optimization (PSO)
algorithm to iteratively optimize the optimal image segmentation
threshold, which addresses the challenge of inaccurate Otsu image
segmentation. Furthermore, the algorithm effectively utilizes the
information of ridge lines, valley lines and the original spectrum in
the wavelet space to enable accurate identification of peak positions.
Results: The proposed method was applied to detect simulated
peaks as well as MALDI-TOF datasets. The performance evaluation was
conducted using receiver operating characteristic (ROC) curves, F1
measure and F-scores. Through comparison with continuous wavelet
transform (CWT) and genetic algorithm-based threshold segmentation
(WSTGA), multi-scale peak detection (MSPD) and CWT and image
segmentation (CWT-IS), the results demonstrated that the WWTPO method
exhibits high performance in peak detection. Conclusions: This
method not only maintains a low false peak identification rate but also
detects more weak peaks and overlapping peaks, further improving the
accuracy and efficiency of peak detection in mass spectrometry. It
possesses a higher capability for efficient peak detection.
Sarcomatoid renal cell carcinoma prognosis prediction based on the machine learning algorithm
Authors: Zhang Rui , Qin Xuefei , Gao Xuelin , Zheng Yu , Hou Guangdong , Zhang Yueyue , Tian Yuchen , Wang Yuliang , Wang Fuli , Ma Shuaijun
Published: July 2023

Abstract Background There is currently no robust prognostic model for
sarcomatous renal cell carcinoma (sRCC), which could help physicians
make better decisions. Objectives To build an accurate predictive model
for patients who have sRCC by investigating the important
characteristics that influence the overall survival of patients. Design
and Methods The Surveillance, Epidemiology and Results (SEER) database
of the U.S. National Cancer Institute was used for gathering the dataset
of sRCC patients. Following data preprocessing, the data was separated
into the training set and the test set in an 8:2 ratio. Mann-Whitney U
test and Chi-square test were used to verify whether the data set was
evenly divided. Univariate Cox proportional hazard model, Kaplan-Meier
analysis and machine learning (ML) algorithm were employed to identify
the risk features on overall survival (OS). 10 reliable features were
selected to construct six ML models. Model performance, predictive
accuracy, and clinical benefits were evaluated by the receiver operating
characteristic curves (ROC), calibration plots, and decision curve
analysis (DCA) respectively. Results After data preprocessing, 692
patients with sRCC from 1975 to 2019 were included in this study. Ten
variables including stage group, T stage, M stage, age, surgery, N
stage, tumor size, chemotherapy, histological grade, and radiotherapy
were selected as reliable features for machine learning model training.
All the models show good prediction performance, among which XGBoost has
the best prediction accuracy and stability. The DCA showed that all
models except Adaboost could be used to support clinical decision-making
with the 90-day, 1-, 2-, 3- and 5-year OS model. Conclusions Six machine
learning models were developed to predict 90-day, 1-, 2-, 3- and 5-year
overall survival in patients with sRCC. Model evaluations showed that
the XGBoost model had the best predictive accuracy and clinical net
benefit. These models can help make treatment decisions for patients
with sRCC.
THERMOPHOTOBIOMODULATION OF STEM CELLS
Authors: Yusupov Vladimir I. , Chailakhyan Ruben K. , Grosheva Alla G. , Vorobieva Nataliya N. , Sviridov Alexander
Published: July 2023

The effect of thermophotobiomodulation (TPBM) was demonstrated, which
leads to a significant increase in the proliferation rate of bone marrow
mesenchymal stem cells (MSCs) of rats due to the combined effect of
moderate heating and laser radiation with a wavelength of λ=980 nm. With
the help of special digital processing methods, it was found that such
an effect, with optimal parameters of TPBM, leads to an increase in the
number of colonies by 4.1 ± 0.5 times, and the total number of cells in
colonies by 3.3 ± 0.4 times compared with the control. It has been shown
that such an increase in the number of cells occurs due to an increase
in the number of colonies formed, which is associated with a
laser-stimulated increase in cell migration activity. Such activation of
MSCs is the most important task of cell transplantology and regenerative
medicine.