bluuebunny/crossref_metadata_2025 huggingface dataset:
VPS13A, a closely associated mitochondrial protein, is required for efficient lysosomal degradation
Authors: Muñoz-Braceras Sandra , Tornero-Écija Alba R. , Vincent Olivier , Escalante Ricardo
Published: February 2019

Members of the VPS13 family are associated with various human diseases. In particular, the loss of function of VPS13A leads to chorea-acanthocytosis (ChAc), a rare neurodegenerative disease without available curative treatments. Autophagy has been considered a promising therapeutic target because the absence of VPS13A causes a defective autophagy flux. However, the mechanistic details of this deficiency are unknown. Here, we identified Rab7A as an interactor of one of the VPS13 family members in Dictyostelium discoideum and we showed that this interaction is conserved between the human homologs VPS13A and RAB7A in HeLa cells. As RAB7A is a key player in endosome trafficking, we addressed the possible function of VPS13A in endosome dynamics and lysosome degradation. Our results suggest that the decrease in autophagy observed in the absence of VPS13A may be the result of a more general defect in endocytic trafficking and lysosomal degradation. Unexpectedly, we found that VPS13A is closely localized to mitochondria, suggesting that the role of VPS13A in the endolysosomal pathway might be related to inter-organelle communication. We show that VPS13A localizes at the interface between mitochondria-endosomes and mitochondria-endoplasmic reticulum and that the presence of membrane contact sites is altered in the absence of VPS13A. Based on these findings, we propose that therapeutic strategies aimed at modulating the endolysosomal pathway may be beneficial in the treatment of ChAc.
Spontaneously infarcted parotid tumours: MRI findings
Authors: Kashiwagi Nobuo , Hyodo Tomoko , Ishi Kazunari , Maenishi Osamu , Enoki Eisuke , Chikugo Takaaki , Masakatsu Tsurusaki , Yagyu Yukinobu , kitano Mutsukazu , Tomiyama Noriyuki
Published: February 2019

Objectives:

To report MRI findings of spontaneous infarction in parotid tumours.

Methods:

14 patients (13 male, 1 female; mean age 73 years) with spontaneously infarcted parotid tumours were reviewed retrospectively. MR images were assessed for the location, the presence of synchronous parotid masses, margin characteristics, signal intensity on T1and T2weighted images, and internal architecture according to the distribution of T2signal hyperintensity.

Results:

12 tumours were located in the parotid tail and 2 in the superficial lobe. Synchronous parotid masses were seen in four tumours, three of which were located in the ipsilateral parotid tail and one in the contralateral parotid tail. Seven tumours had well-defined margins and seven had ill-defined margins. The signal intensities on T1weighted images were a mixture of high and intermediate in all cases; in 11 tumours, hyperintense areas were dominant. On T2weighted images, all tumours also showed a mixture of high and intermediate signal intensities. Internal architectures on T2weighted images were mosaic hyperintensity in three tumours, central hyperintensity in five, and multiseparated hyperintensity in six.

Conclusions:

Spontaneously infarcted parotid tumours were mostly located in the parotid tail and showed mixed signal intensities with predominant hyperintensity on T1weighted images. Half of the tumours had ill-defined margins, and the internal architectures varied.
The Development of School Textbooks (a Brief History and Some Conclusions)
Authors: Кузнецов А. , Kuznetsov A. , Чернобай Е. , Chernobay E.
Published: February 2019

The article presents a brief overview of the development of processes related to the publication of school textbooks. The authors show how the requirements for educational literature have changed due to changes in the tasks arising in the school system.
Palavras associadas ao câncer infantil: um levantamento exploratório
Authors: Rocha Christiane Delúsia de Oliveira , Viana-Meireles Lívia Gomes , Oliva Angela Donato
Published: February 2019

O diagnóstico de câncer em crianças causa um forte impacto na população, acompanhado principalmente por pensamentos negativos, apesar dos índices de cura terem aumentado nos últimos anos. Assim sendo, o presente estudo teve por objetivo analisar a percepção acerca do câncer infantil. Participaram 331 adultos, 155 com ou sem filhos e 176 pais de crianças com câncer. Para tanto, foram utilizados dois tipos de questionário: um sóciodemográfico, e outro de percepções sobre o câncer infantil. Os dados foram analisados através da estatística descritiva e uso do qui-quadrado. Os resultados indicaram que as percepções relacionadas ao câncer são predominantemente negativas. Diante disso, conclui-se que o câncer infantil está relacionado a um estigma de morte e sofrimento, o que está em contradição com os índices atuais de cura. Desse modo, o investimento no desenvolvimento de um trabalho de informação e conscientização da população pode ser importante para que o câncer seja visto de uma maneira mais realista.
Funk ousadia, adolescência, contemporaneidade: uma leitura lacaniana
Authors: Lima Vinícius Moreira
Published: February 2019

O funk ousadia é um recente subgênero do funk cujas letras apresentam temas recorrentes: conteúdo radicalmente pornográfico, envolvendo a figura da "novinha" e recorrendo a várias gírias para os órgãos genitais, em meio a polêmicas judiciais, boa recepção de seu público-alvo e má recepção de setores sociais conservadores. A presença de uma quantidade considerável de MCs adolescentes no funk ousadia nos leva a propor que, no tempo lógico de encontro com a não relação sexual, em uma época de declínio da função paterna e estimuladora de uma perversão ordinária, esses MCs fazem um semblante de saber sobre o sexo — ou depositam-no na "novinha" — como forma de tratamento do gozo e da não relação sexual, criando um nome próprio para si por meio do funk, constituindo, para tanto, uma rede de identificações horizontais com sujeitos especulares em busca de consistência, contornando o Real pulsional em jogo na puberdade.
Assessment of Ground Water Contamination by Inorganic Impurities in Ferozepur District of Punjab State, India
Authors: Kaur Gurjeet , Sharma Sangeeta , Garg Umesh Kumar
Published: February 2019

Malwa region of Punjab state, India has become the center of water borne diseases due to excessive use of pesticides, chemical fertilizers, heavy metals, industrial toxins that cause toxicity in water. The main contamination in ground water is by physico-chemical parameters and heavy metals i.e. pH, total dissolved solids, total alkalinity, total hardness, calcium, chlorides, fluorides, arsenic and lead. The contamination of ground water with heavy metals causes health hazards to humans and animals. Due to lack of adequate facilities and resources for the management and handling of waste, the ground water contamination has been increased. In the present study, assessment of ground water quality was carried out in the villages of Ferozepur district of Punjab state, India. With main emphasis on analyzing the groundwater parameters of Ferozepur district which are responsible for health hazard to humans and animals. Various groundwater samples were collected randomly from the villages of Ferozepur district and analyzed for pH, total dissolved solids, total alkalinity, total hardness, calcium, chlorides, fluorides, heavy metals (arsenic and lead) using standard procedures. The concentrations of calcium, chlorides, fluorides and pH were within the permissible limits, whereas, alkalinity and total hardness were observed beyond permissible limits in most of the water samples. Even among majority of the samples taken, the concentration of arsenic and lead was found within the permissible limits. Results showed that the ground water samples collected from depth ranging from 100 to 360 ft, recorded values within permissible limits for drinking purpose as prescribed by WHO. Further, ANOVA has been applied on analysis results to study the effect of pH on fluoride and chloride, depth on fluoride and chloride and depth on arsenic and lead. Also, to adjudge the overall quality of water in Ferozepur district, the water quality index (WQI) has been calculated on the basis of large number of physico-chemical characteristics of water. The water quality index of ground water in Ferozepur district has been calculated to be 107. The value is close to 100 so the quality of ground water in Ferozepur
district can be categorized under 'Good Quality' water.
Preparation and Characterization of New Carrier Drug Polymers Based Maleimide and Its Drug Release Behaviour
Authors: Razzak Mageed Fatimah Abdul , Kareem Mohanad Musa , Al-Baiati Mohammad N.
Published: February 2019

In this work, two new drug substituted monomers and new homogenous and heterogeneous polymers were synthesized loaded with medicinal properties to extend the controlled drug. The first step includes preparation of compound (F1) via reaction of maleic anhydride with 4-aminobenzoic acid. Then compound (F1) was converted to its corresponding acyl chloride derivative which reacted with amino drugs (sulfadiazine, chlordiazepoxide) afforded (F2 and F3) monomers. Homogeneous polymers (F8 and F9) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. Heterogeneous polymers (F14 and F15) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) separately with acrylic acid under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. All these prepared monomers and polymers were characterized by FT-IR and 1H NMR, 13C NMR spectroscopies. Controlled drug release and swelling % was studied in different pH values at 37 ºC. Intrinsic viscosities were measured at 25 ºC with Ostwald viscometer and applied the characteristic of solubility for these polymers.
Theoretical Study of Sigmatropic Rearrangement of Cycloprop-2-en-1-ol and its Fluorine Derivatives: Pericyclic or Pseudopericyclic Character from NICS and LLPE
Authors: Sangeetha A. , Ansari A. Thaminum , Jeevanandam Jebakumar , Jayaprakash S.
Published: February 2019

Sigmatropic rearrangement reaction of cycloprop-2-en-1-ol and its fluorine derivatives has been studied theoretically in gas phase and its energy barrier has been calculated. Nucleus-independent chemical shift (NICS) shows sigmatropic rearrangement of cycloprop-2-en-1-ol is pericyclic in nature whereas fluorine derivatives show pseudopericyclic and pericyclic nature. Substitution of fluorine atom at ring is found to increase the energy barrier for –OH migration, while substitution at oxygen atom reduces the barrier. To know the involvement of lone pair of electrons during the reaction, lone pair electron present on oxygen atom is locked by hydrogen bonding. CR-CCSD(T)/6-311+G** levels are used to study the reactions more accurately.
An Empirical study on availability of Health Care Services in Zarol village as per the Indian Public Health Standards
Authors: Mitra Anupam , Shukla Shivangi
Published: February 2019

An Empirical study on the topic of an availability of Health care services in Zarol village as per the Indian Public Health Standards has been undertaken with the main objective to find out the prevailing gap between expected health standards and actual Indian Public health standards. The study was descriptive in nature. A sample of 80 respondents were undertaken for survey. Data were collected through structured closed ended questionnaire by using Non-probability convenience sampling method through personally interviewing the respondents. The analysis was done by using various tests in SPSS. The Service Quality Dimensions were used to measure the Service Quality Assurance of Public Health care services.
Faith - Based Teacher Emotional Experiences: A Case Study of a Veteran English Lecturer in China
Authors: Ding Xiaowei , De Costa Peter I.
Published: February 2019

The exploration of links between faith and second language pedagogy has been underexplored, and the emotional experiences of English language teachers of religious faith are even less studied in applied linguistics circles. This qualitative case study is an effort to address this gap in the research by investigating the faith-based emotional experiences of May, a veteran English lecturer practicing Buddhism in China, by drawing on multiple data sources that include interviews, classroom observations, WeChat conversations, student evaluations, and researcher journals. Our findings revealed that (1) May’s emotional experiences were strongly driven by and deeply derived from her Buddhist faith and other aspects of identity in the classroom; (2) her faith-based emotional experiences were dynamic and fluid; (3) her faith-based identity occupied a central position alongside her professional identities and had a transformative influence on both her emotional experiences and her identity development; and (4) the interactions among her emotional experiences, multiple identities, and pedagogical praxis were complex and reciprocal. The research implications, limitations and future directions are also discussed.
An Effective Diffeomorphic Model and Its Fast Multigrid Algorithm for Registration of Lung CT Images
Authors: Thompson Tony , Chen Ke
Published: February 2019

Image registration is the process of aligning sets of similar, but different, intensity image functions to track changes between the images. In medical image problems involving lung images, variational registration models are a very powerful tool which can aid in effective treatment of various lung conditions and diseases. However, a common drawback of many variational models, such as the diffusion model and even optic flow models,
is the lack of control of folding in the deformations leading to physically inaccurate transformations. For this reason, such models are generally not suitable for real life lung imaging problems where folding cannot occur.

There are two approaches offering reliable solutions (though not necessarily accurate).
The first approach is a parametric model such as the affine registration model, still widely used in many applications, but is unable to track local changes or yield accurate results.
The second approach is to impose an extra constraint on the transformation of registration
at the cost of increased non-linearity.

An alternative to the second approach, achieving diffeomorphic transforms without adding any constraints, is an inverse consistent model such as by Christensen and Johnson (2001) from computing explicitly both the forward and inverse transforms. However, one must deal with the strong non-linearity in the formulation.

In this paper we first propose a simplified inverse consistent model to avoid the inclusion of strong non-linearities and then a fast non-linear multigrid (NMG) technique to overcome the extra computational work required by the inverse consistent model. Experiments, performed on real medical CT images, show that our proposed inverse consistent model is robust to both parameter choice and non-folding in the transformations when compared with diffusion type models.
Wideband High Gain Cylindrical Dielectric Resonator Antenna for X-Band Applications
Authors: Mishra Nipun K. , Das Soma , Vishwakarma Dinesh K.
Published: February 2019

In present work a wide band and high gain cylindrical dielectric resonator antenna working in X-band has been designed and validated experimentally. First the bandwidth of the antenna has been enhanced by placing the thin dielectric layer between antenna and feed network. Next gain of the antenna has been increased by placing a layer of high dielectric material at nearly λ/2 distance as superstrate. The proposed design with impedance bandwidth of 3 GHz and gain nearly 11dBi could be used in satellite communication and other wideband wireless applications operating in X-band.
Predicting structural timber grade-determining properties using acoustic and density measurements on young Sitka spruce trees and logs
Authors: Simic Karlo , Gendvilas Vilius , O’Reilly Conor , Harte Annette M.
Published: February 2019

In Ireland, most structural timber from Sitka spruce (Picea sitchensis [Bong.] Carr.) is machine graded into C16 strength class. However, timber from early thinnings is mostly used for non-structural applications. There is an increased demand for structural timber, and timber from young trees could contribute to wood supply. However, this timber has lower mechanical properties than mature timber. In order to pre-sort the resource for structural application of wood from thinning, the possibilities of acoustic and density (D) measurements on young trees and logs have been investigated. The stress wave velocity (SWV) and pin penetration depth (PD) were measured on standing trees, which were then felled and cut into 10-m-long logs and subsequently into 3-m-long logs. Fundamental frequency was measured on logs. Finally, the logs were processed into boards, which were tested in accordance with EN 408 to obtain modulus of elasticity (MOE) in bending, bending strength (BStr) and D. The results showed good relationships between timber properties and acoustic and D measurements. Models for predicting grade properties of timber from thinnings are presented. Pre-sorting of young Sitka spruce trees and logs helped obtain higher C16 yields.
Will I, Wont I? Factors associated with self-reported prediction of future indulgence in intimate partner violence among adolescents in South India
Authors: Abdulkader Rizwan Suliankatchi , Sathiyamoorthy Krithikalakshmi , Jeyashree Kathiresan
Published: February 2019

Introduction

Intimate partner violence (IPV) refers to acts of physical/sexual violence, emotional/psychological abuse and controlling behaviour by a current or former intimate partner. Understanding the attitudes and perspectives of adolescents towards IPV can help in its prevention. The study aimed to assess the knowledge about various domains of IPV and self-reported prediction of perpetrating IPV among adolescents in Madurai city, South India.

Methods

Students pursuing engineering, medicine and humanities were recruited conveniently. A structured self-administered questionnaire developed to cater to the objectives was used. After descriptive analysis, a modified Poisson regression with robust variance estimation was used to identify factors associated with one’s self-reported prediction of becoming an IPV perpetrator and adjusted relative risks [0.95 confidence interval (CI)] were calculated. The project was approved by the Institute’s Ethics Committee.

Results

Of the 369 students, 40% were aware of IPV prevalence among women in India. About 85% agreed with societally prescribed gender roles. More males than females found gender roles manifesting as IPV acceptable (p = 0.003). Only 6.8%, more females than males (p = 0.01), believed that no violence is permissible in intimate relationships. About 55% definitely did not foresee themselves becoming IPV perpetrators. Belief in gender roles [odds ratio (OR) = 3.85; 95% CI: 1.26, 11.74] and being a professional course student (2.48; 1.25, 4.91) were significantly associated with foreseeing oneself as an IPV perpetrator.

Conclusion

Knowledge about IPV and its redressal mechanisms among adolescents is poor. A significant proportion of them believe in gender roles and perceive violence within an intimate relationship as acceptable. Positively influencing adolescents’ beliefs in gender roles may help to control IPV and nurture healthier relationships.
Modelling and Dynamic Stability Study of Interconnected System of Renewable Energy Sources and Grid for Rural Electrification
Authors: Bhamu Swati , Bhatti T. S. , Pathak Nikhil
Published: February 2019

This paper presents modelling and dynamic stability study of an interconnected system of renewable energy sources (RES) and grid. The objective of this system is to utilize RES for providing continuous power to a cluster of villages having fixed feed of power supply from the grid. The renewable energy sources considered in the interconnected system are wind and biogas. Therefore, dynamic models for doubly fed induction generator (DFIG) and squirrel cage induction generator (SCIG) based wind energy conversion system have been developed for the proposed interconnected system. The static synchronous compensator (STATCOM) has also been employed to stabilize system voltage as per the requirement while, synchronous generator-based biogas genset has been used for system frequency and voltage regulation. The behavior of the proposed system has been analyzed under various load and input wind power disturbances.
Power–gap relationships in low consistency refining
Authors: Rubiano Berna Jorge Enrique , Martinez Mark , Olson James
Published: February 2019

Distance between stationary and rotating refining plates, gap, has a direct and significant impact on refining power. Gap is almost universally used to control power in low consistency refining operations. The relationship between power and gap are affected by refiner size, pulp type, plate pattern and refining conditions. In this study, a correlation was developed to describe the power–gap relationships at a wide range of refining conditions and furnish. The correlation was developed using pilot-scale refining data of mechanical pulps. Results showed that a properly defined dimensionless power number is suitable to describe refining power as well as to compare different refiners under the same grounds. The developed correlation was also used to predict mill-scale refining data showing good agreement with between predicted and measured values. Finally, experimental data from force sensor measurements supports the correlation’s theoretical assumptions.
Effect of grain size on radon emanation coefficient, surface and mass exhalation rates and the correlation coefficient between them in different masses of soil and phosphate fertilizer
Authors: Alshahri Fatimh
Published: February 2019

It is important to study the behavior of recoiling radon atoms 222Rn after decay of parent 226Ra and the effect of parameters on their access to the surrounding medium. The present study was carried out using CR-39 detector to study the effect of grain size on the correlation between surface and mass exhalation rates and the correlation between emanation coefficient and exhalation rate at different masses of soil and phosphate fertilizer. In addition, the relationship between emanation coefficient and the sample mass was studied for different grain sizes (0.1, 0.3, 0.5 and 1 mm). The results showed that there is no effect of grain sizes on the correlation coefficient between surface and mass exhalation rates in soil and fertilizer. The correlation coefficient between emanation coefficient and exhalation rate in different masses of soil was slightly influenced by the grain sizes. While the correlation coefficient between emanation coefficient and exhalation rate in different masses of phosphate fertilizer samples was not affected by the grain sizes (0.1, 0.3 and 0.5 mm). However, it was found that the emanation coefficient decreases exponentially with the mass for soil and phosphate fertilizer. This relationship was not significantly affected by grain size in soil except grain size 1 mm. While this relationship was affected by grain size >0.3 mm in phosphate fertilizer.
Protective effect of extract of Bletilla striata on isoflurane induced neuronal injury by altering PI3K/Akt pathway
Authors: Zhao Guoqing , Li Kai , Chen Junyang , Li Longyun
Published: February 2019

Background

Present investigation evaluates the neuroprotective effect of Bletilla striata on isoflurane induced neuronal injury rat model.

Methodology

Neuronal injury was induced by exposing the pups (P7) isoflurane (0.75%) in oxygen (30%) for the period of 6 hr and rats were treated with Bletilla striata at a dose of 35, 70 and 140 mg/kg, p.o. for the period of 21 days. At the end of protocol neurological score was estimated and serum concentration of inflammatory cytokines was estimated. Isolated brains tissue was prepared to perform immunohistochemical analysis, TUNEL assay and western blot assay.

Results

Result of the study reveals that treatment with BS significantly (p<0.01) reduces the neurological score compared to negative control group. Level of inflammatory cytokines in the serum and the expression of p-Akt, Bcl-xL and Bad protein were significantly attenuated in BS treated group. Moreover the cleaved caspase-3 and TUNEL positive cell was significantly (p<0.01) reduced in BS treated group compared to negative control group of rats.

Conclusion

Present study concludes that ethanolic extract of Bletilla striata protects the neuronal injury by reducing apoptosis in isoflurane induced neuronal injury rats.
Primary Immunodeficiency in the NICU
Authors: O’Connell Amy E.
Published: February 2019

Primary immunodeficiency disorders (PIDs) are genetic diseases that lead to increased susceptibility to infection. Hundreds of PIDs have now been described, but a select subset commonly presents in the neonatal period. Neonates, especially premature newborns, have relative immune immaturity that makes it challenging to differentiate PIDs from intrinsic immaturity. Nonetheless, early identification and appropriate management of PIDs are critical, and the neonatal clinician should be familiar with a range of PIDs and their presentations. The neonatal clinician should also be aware of the importance of consulting with an immunologist when a PID is suspected. The role of newborn screening for severe combined immunodeficiency, as well as the initial steps of laboratory evaluation for a PID should be familiar to those caring for neonates. Finally, it is important for providers to be familiar with the initial management steps that can be taken to reduce the risk of infection in affected patients.
Novel Drugs of Abuse
Authors: Wang George Sam , Hoyte Christopher
Published: February 2019

Novel drugs of abuse are synthetic illicit drugs, or analogues of known illicit drugs, that can be more potent. Novel drugs of abuse are often labeled as designer drugs, research chemicals, legal highs, or psychoactive substances. They are often sold as designated legal or nondrug products, such as incense, plant food, or bath salts, with labeling such as “Not for Human Consumption” or “For Use in Research Only.” The prevalence of use of novel drugs of abuse is difficult to determine because specific drugs, compounds, and availability of these drugs are constantly evolving. Changes in chemical structures lead to heterogeneity in physiologic response and clinical symptoms, even within the same category of drug. Pediatricians and emergency medicine physicians should be knowledgeable about novel drugs of abuse and their resulting symptoms for prevention and identification of their use.
Expectativas de los estudiantes de Trabajo Social sobre su desempeño profesional con víctimas de violencia familiar y de género: un estudio cualitativo
Authors: Santana Hernández Juana Dolores
Published: February 2019

Este artículo presenta los resultados de una investigación cualitativa sobre las expectativas de estudiantes de Trabajo Social sobre su actuación futura en los contextos de violencia familiar y de género. Participaron 59 estudiantes del último año del Grado en Trabajo Social de la Universidad de La Laguna, España, quienes revelaron que el trabajo con víctimas y supervivientes de violencia familiar y de pareja presenta una serie de exigencias y retos para los trabajadores y las trabajadoras sociales. Se concluye con recomendaciones para la docencia, la investigación y la práctica profesional en este ámbito de trabajo.
La malnutrición: más allá de las deficiencias nutricionales
Authors: Quevedo Bolívar Paula Alexandra
Published: February 2019

La malnutrición es un problema de salud pública que afecta a más de la mitad de la población del mundo. Sienta sus bases en los hábitos de consumo que ha promovido la industria alimentaria y que tiene como producto estrella aquellos que tienen poco valor nutritivo y alto contenido de azucares y grasas. Una solución a esta problemática es la educación nutricional, a través de la cual se busca fomentar el desarrollo de actitudes y prácticas que permitan a las personas mejorar y preservar su estado nutricional y desarrollar las competencias necesarias para su inserción en el mundo social.
El diálogo y el trabajo en red: aproximaciones a la experiencia de un escenario de coordinación interinstitucional
Authors: Barreto Lugo Liliani
Published: February 2019

El presente artículo ofrece una reflexión en torno a los esfuerzos de coordinación o articulación interinstitucional, no solo en cuanto acción de política pública sino también como emprendimiento pensado en clave de red de relaciones y procesos de diálogo en permanente interacción con la comunidad sujeto del acompañamiento institucional. Para ello, se parte de la investigación sobre la experiencia del Comité Interinstitucional, que está encargado del acompañamiento social a la población beneficiaria del Proyecto de Vivienda de Interés Prioritario Casas de Llano Verde de la ciudad de Cali, Colombia, cuya comunidad se constituye mayoritariamente por población víctima de desplazamiento forzado.
Háblame a los Ojos
Authors: Murcia Albañil Diana Marcela
Published: February 2019

Pepita Cedillo es una mujer sorda, hija de padres oyentes. Es diplomada en profesorado de educación básica general, especialista en patología del lenguaje y profesora de lengua de signos catalana. Trabaja como logopeda y maestra de estudiantes sordos.En este libro, el Trabajo Social encuentra pautas sobre la forma en que se pueden presentar argumentos teóricos disciplinares mediante el uso de la historia de vida narrada en primera persona. En el desarrollo del libro se pueden observar las descripciones de la conformación familiar, la estructura y las interacciones, en un lenguaje ameno que guía al lector por diferentes situaciones de interés disciplinar.La autora nos permite descubrir la manera en que un diagnóstico de sordera profunda impacta las relaciones cotidianas de una familia, las interacciones de una persona sorda con una hermana menor oyente, y los diferentes momentos de la socialización primaria en los primeros años de escuela. El libro presenta la manera en que una persona sorda moviliza por sí misma sus redes, encuentra trabajo, conforma relaciones de amistad, se desenvuelve en diferentes escenarios y su percepción sobre la recepción de ayudas terapéuticas. Presenta los intercambios de lengua en los diferentes escenarios de socialización y permite intuir las posibles interacciones con la intervención psicosocial en esos espacios.
Presentación
Authors: Vásquez Cruz Olga Del Pilar
Published: February 2019

La foto que ilustra la portada del fascículo número 21-1 (enero-junio de 2019) fue tomada durante una de las movilizaciones estudiantiles desarrolladas entre octubre y noviembre de 2018. En estas se reclamaba al Estado colombiano el Derecho a la Educación Superior de calidad. Los bellos murales de la calle 26 parecen testigos silenciosos del clamor de los estudiantes, quienes hacían evidente con sus arengas y carteles la creciente desfinanciación del sistema estatal de educación superior, la situación de precariedad en las infraestructuras físicas de las universidades públicas, la insuficiencia de profesores versus el creciente número de programas y alumnos, entre otras. Esta movilización acompañó la declaración de paro en más de 35 universidades e instituciones de educación superior de carácter público, por más de 60 días.Además de lograr, hacia el mes de diciembre, un acuerdo con los representantes del actual Gobierno para superar estos escollos, los estudiantes consiguieron evidenciar esta situación como un problema que atañe a toda la sociedad colombiana. De hecho, muchos problemas que hoy aquejan a nuestras sociedades no son visibles sino hasta que tocan nuestro razonamiento y nuestra sensibilidad. En esta ocasión, la revista Trabajo Social expone en 7 de los 9 artículos que la conforman los resultados de investigaciones que plantean, de manera rigurosa y diáfana, problemáticas sociales que preocupan desde profesionales de diversas disciplinas de las ciencias sociales y entidades del Estado, hasta organizaciones de la sociedad civil, organismos multilaterales y de cooperación.
From Honor to Dignity: Criminal Libel, Press Freedom, and Racist Speech in Brazil and the United States
Authors: French Jan Hoffman
Published: February 2019

Reports on violence against journalists in Brazil have captured the concern of international human rights organizations. This article discusses a case involving another such concern: the use of criminal defamation laws in Brazil to punish journalists for criticizing public officials. At the same time, Brazilian media sources regularly report on crimes of racism, which most often involve derogatory name-calling and hate speech. By examining the intersection of these apparently contradictory concerns, this article sheds new light on speech rights in Brazil and the United States and argues that a comparative perspective is crucial to contextualizing and harmonizing free speech and its limitations under modern democratic constitutions. By considering the infusion of traditional notions of honor and status with post-World War II views of dignity, this article argues for a comparative consideration of how best to combat racism and whether hate speech regulation in the U.S. should be reconsidered. As such, the type of law often used to protect the powerful in Brazil could come to be used to protect the vulnerable in the United States and opens the possibility that the irony of free speech could become more than just a scholarly debate.
Maldito “Jarabe gatuno”: Poéticas de la censura inquisitorial en la Nueva España
Authors: Deanda Camacho Elena
Published: February 2019

Un análisis a la censura inquisitorial que persiguió la canción o ‘son de la tierra’ llamado “Jarabe gatuno” o “Pan de jarabe” en la Nueva España del siglo dieciocho desvela una doble dinámica de reproducción del discurso en la cual, por un lado, el discurso considerado ‘obsceno’ contamina el discurso legal y se ve preservado, mientras que, por otro lado, el discurso legal se mimetiza con lo ‘obsceno’ replicándolo, citándolo, en una continua reverberación. En esta dinámica de apropiación, contaminación o invasión discursiva es posible dilucidar una poética de la censura en la cual el discurso legal responde con las mismas estrategias discursivas que expone el discurso que condena.
The Politics of Ability and Online Culture Wars
Authors: Watson Steven
Published: February 2019

Conversations about 'fixed' or innate ability in relation to schools and education have generally considered – though not exclusively so – the psychological and sociological basis of ability, the practicalities and policy formulations. In this article, the author considers
the emergent politics of ability and the culture war on social media which appears to be driving the discourse. He draws on his own research in this and presents an article which is intended to highlight the nature of the politics of ability and offer some insights into how practitioners and
academics might move forward in a more productive way. Essentially, sustained debate over the nature of ability as fixed or as a flexible characteristic can prove to be irresolvable. He argues that what can potentially unite both sides of the debate is a greater sense of justice in terms of
social class and political economy.
Influence of ultra-fine slag and silica fume on properties of high-strength concrete
Authors: Ting Luo , Qiang Wang , Yuqi Zhou
Published: February 2019

The effects of ultra-fine slag (UFS) and silica fume (SF) on the compressive strength and durability-related properties of high-strength concrete were compared, and the mechanism of these effects was analysed. Portland cement was replaced with UFS or SF in amounts of 10% and 15% by mass in cement with a water/binder ratio of 0·25. The cement paste containing UFS shows better fluidity and dispersibility than that containing SF. The UFS concrete shows faster strength development at early ages (3 and 7 d). However, UFS concrete has a lower strength after 28 d than SF concrete. The resistance of the UFS concrete to chloride ion penetration at ages of 28 and 60 d was slightly lower than that of SF concrete, but UFS concrete could reach the same chloride ion permeability grade as SF concrete. The water absorption of UFS concrete at 60 d is relatively higher than that of SF concrete during the entire absorption process. Significantly, concrete with 15% UFS replacement can achieve the same water absorption effect as concrete with 10% SF. The incorporation of UFS in the cement pastes induced quicker early-age cracking than was observed in SF-blended cement pastes.
protocol v1
Authors: Niu Yanli , Peng Yansong , Chen Wenxing , Zhan Xuaihuai , Chachar Sadaruddin , Zhang Pingxian , Zhou Saixi , not provided Yanli , zhen Song Man
Published: February 2019

SSR and SRAP markers were applied to assess the genetic diversity and structure of four populations of sixty-four samples ofEmmenopterys henryi. 12 pairs of SRAP primers generated 86 bands, and polymorphism rate was 88.4%. Higher values of genetic diversity parameters (h = 0.3195, I = 0.4757, PPB = 69377%, at the species level; h = 0.2632, I = 0.3868, PPB = 89.53%, at the population level) demonstrated relatively higher level of genetic diversity. A total of 150 alleles were detected using 10 pairs of SSR primer. The number of alleles per locus ranged from 7 to 24, with an average of 15 alleles of each locus. The genetic diversity parameters (h = 0.091, I = 0.176, PPB = 99.33%, at the species level; h = 0.0829, I = 0.1447, PPB = 50.34%, at the population level) were obtained. Population genetic differentiation level of E.henryi (SRAP, GST= 0.1936; SSR, GST = 0.0944) was higher compared to other species. AMOVA revealed that genetic variation mainly existed within populations. For SRAP markers, UPGMA dendrogram and PCA cluster analysis separate HS and DWS populations from other populations. But for SSR markers, UPGMA dendrogram and PCA cluster analysis divided 4 populations into 3 groups but was not obvious, and indicated the extent of admixture within some samples. It seemed the extant of genetic pattern of E.henryi might have mainly attributed to its long evolutionary history, wide-ranging distribution, outcross mating system and human activities. The genetic diversity parameters (Na, Ne, h, I)(except for Na at the species level ) revealed by SRAP markers were higher than that by SSR markers, but genetic distance calculated based on SSR markers was larger than that based on SRAP markers. Based on the conservation of germplasm resources and genetic diversity, the combination of SRAP and SSR markers could fully implement conservation and sustainable exploitation of the endangered plant E.henryi.
Current approaches to treatment of antiphospholipid syndrome during pregnancy: a case report
Authors: Kornyushina Ekaterina A.
Published: February 2019

The article presents a clinical case of a patient with antiphospholipid syndrome (APS), with a history of deep vein thrombosis and recurrent miscarriage. The methods of additional therapy for APS during pregnancy, which are used in cases of miscarriage refractory to the standard treatment, are described: administration of intravenous immunoglobulin, plasma exchange, glucocorticosteroids. The literature data on the use of additional APS therapy in pregnancy are given.
Sclerotic adenomyosis: a case report
Authors: Yarmolinskaya Maria I. , Ailamazyan Eduard K. , Arutyunyan Arutyun F. , Dolinskiy Andrey K. , Gaidukov Sergey N.
Published: February 2019

Four hundred and fifty case histories and results of histological studies of patients who underwent surgical treatment with a diagnosis of adenomyosis and uterine fibroids were retrospectively analyzed. Of all the operated patients, the sclerotic type of adenomyosis was detected in three cases according to the histological examination, which was 0.67%. The retrospective analysis allowed us to reveal the clinical, echographic, and histological characteristics of the sclerotic type of adenomyosis in these patients.
Substantiated approaches to the diagnosis and treatment of tamoxifen-induced endometrial conditions in patients with breast cancer
Authors: Protasova Anna E. , Solntseva Irina A. , Tsypurdeyeva Anna A. , Semiglazova Tatyana Yu. , Stenina Marina B. , Yureneva Svetlana V. , Yakushevskaya Oksana V.
Published: February 2019

Currently, tamoxifen is the gold standard in the treatment of hormone receptor-positive breast cancer, which reduces recurrent tumor risk by more than 40%. Tamoxifen, which belongs to selective estrogen receptor modulators, can cause endometrial changes in women of different age groups and increase the risk of hyperplasia and endometrial cancer by several times. In clinical practice, the occurrence of various endometrial alterations during tamoxifen treatment often leads to groundless drug withdrawal. Oncology, gynecology and radiology community knowledge related to optimal methods and criteria for diagnosing different tamoxifen-induced endometrial conditions, as well as in choosing the optimal treatment tactics, will be instrumental in the unified and correct approach to managing patients with hormone receptor-positive breast cancer and maintaining tamoxifen therapy due to its high effectiveness.
EPOCHA-AH 1998–2017. Dynamics of prevalence, awareness of arterial hypertension, treatment coverage, and effective control of blood pressure in the European part of the Russian Federation
Authors: Badin Yu. V. , Fomin I. V. , Belenkov Yu. N. , Mareev V. Yu. , Ageev F. T. , Polyakov D. S. , Artemjeva E. G. , Galyavich A. S. , Ionova T. S. , Kamalov G. M. , Kechedzhieva S. G. , Koziolova N. A. , Malenkova V. Yu. , Malchikova S. V. , Smirnova E. A. , Tarlovskaya E. I. , Shechrbinina E. V. , Valikulova F. Yu. , Vaysberg A. R. , Yakushin S. S.
Published: February 2019

Aim.To perform a repeated epidemiological study of a representative sample in the European part of the Russian Federation in 2017 and to compare the dynamics of arterial hypertension (AH) prevalence with the eﬀectiveness of blood pressure (BP) control in the population compared to 1998, 2002, and 2007.

Materials and methods.A representative sample of the European part of the Russian Federation was created in 2002 and re-examined in 2007 and 2017. In 1998, a pilot project was performed for examining a representative sample for the Nizhniy Novgorod region.

Results.During 19 years of follow-up, the AH prevalence increased from 35.5 to 43.3%. Te awareness and treatment coverage reached 76.9 and 79.3%, respectively, in 2017. Achievement of the target BP with a single measurement also increased among patients receiving antihypertensive medication from 14.3 to 34.9%. For the treatment of AH, medium-acting antihypertensive drugs are used, ofen at suboptimal doses.

Conclusion.Epidemiological indices of awareness, treatment coverage, and number of eﬀectively managed patients with AH have improved. However, the AH prevalence has increased by 7.8% for 19 years, which indicates inefciency of the primary prevention of this disease.
Paulo Freire: um patronato ameaçado
Authors: Brayner Flavio Henrique Albert
Published: February 2019

Este artigo procura mostrar que a tentativa recorrente de expulsar as ideias de Paulo Freire do cenário pedagógico brasileiro não é apenas um ataque pedagógico nem deve ser vista como simples ações reacionárias de grupos protofascistas. Sugere-se que se trata de algo mais profundo, e o que está em jogo são o fim do espaço público e a tentativa de redescrever a figura do “sujeito” a partir de supostos que excluem a ideia de consciência judicativa e crítica.

Palavras-chave: Patronato. Espaço público. Partidarismo pedagógico. Escola sem Partido.

Paulo Freire: a threatened patronage

AbstractThis article tries to show that the recurrent attempt to expel Paulo Freire’s ideas from the Brazilian pedagogical scene is not only a pedagogical attack nor should it be seen as simple reactionary actions of protofascist groups. It is suggested that this is something deeper, and what is at stake is the end of public space and the attempt to redescribe the figure of the “subject” from suppositions that excludethe idea of critical and judicial consciousness.

Keywords: Patronage. Public space. Pedagogical partisanship. School without Party.

Paulo Freire: un patronato amenazado

ResumenEste artículo busca mostrar que el intento recurrente de expulsar las ideas de Paulo Freire del escenario pedagógico brasileño no es sólo un ataque pedagógico ni debe ser visto como simples acciones reaccionarias de grupos protofascistas. Se sugiere que se trata de algo más profundo, y lo que está en juego son el fin del espacio público y el intento de reescribir la figura del “sujeto” a partir de supuestos que excluyen la idea de conciencia judicativa y crítica.

Palabras clave: Patronato. Espacio público. Partidarismo pedagógico. Escuela sin Partido.
PARADIGMA ISLAM DALAM METODOLOGI PENELITIAN DAN IMPLIKASINYA TERHADAP PENELITIAN PENDIDIKAN AGAMA ISLAM
Authors: Hidayat Tatang , Asyafah Abas
Published: February 2019

In principle, research is considered as an important thing in the realm of academics, especially for students and lecturers. However, in the reality, it is still easily found that many academia encounter difficulties in conducting research, especially in the field of Islamic education in which its paradigm is different compared to others. The purpose of this present study is to investigate the Islamic paradigm in research methodology and its implication for Islamic Education studies.

This study employed a qualitative approach and literature review method. The collected data were analyzed thoroughly using a descriptive analysis method and in the same time, the writer also elaborated as well as provided understanding and explanation proportionally. Based on the results of the discussion, it is obvious that the Islamic paradigm appeared to be different from the paradigm developed by the western world in research methodology. The Islamic paradigm considers that science is not value-free. In addition, the Islamic paradigm has a special characteristic which is different from other paradigms. As a result, a researcher puts Islam as a fundamental paradigm in conducting research on Islamic Education and it in fact has implications for the research processes from the beginning to the end of the research, in relation to research intentions, finding problems, formulating the background of the research problems, formulating research problems, research objectives, research benefits, research theories, and research methodology. In particular, research methodology in this case covers bayani, burhani, tajribi, and 'irfani method. Similarly, all the processes covering data processing, data analysis, conclusions, research publication, research facilities, and all necessary things related to the research should always be associated with the commands and prohibitions as well as permission of Allah Subhanahu wa Ta’ala.