bluuebunny/crossref_metadata_2025 huggingface dataset:
microRNA-1236-3p regulates DDP resistance in lung cancer cells
Authors: Wang Zhigang , Liu Limei , Guo Xiaofeng , Guo Chunmei , Wang Wenxia
Published: February 2019

Lung cancer is a malignant tumor leading to the most cancer-related deaths worldwide. The treatment efficiency of lung cancer remains poor mainly due to chemotherapy drug resistance, including cisplatin. MicroRNAs (miRNAs) are closely related to chemotherapy resistance of tumor cells. Here, we illustrated the underlying mechanism of miR-1236-3p on the DDP resistance in lung cancer cells. In this study, we found that the expression level of miR-1236-3p was significantly decreased in lung cancer tissues and A549 cell line. In addition, the half maximal inhibitory concentration (IC50) of DDP in A549 cells was significantly lower than that in A549/DDP cells, while the expression level of miR-1236-3p was prominently down-regulated in A549/DDP cells. Combining the online tool TargetScan and a dual-luciferase reporter assay, tumor protein, translationally-controlled 1 (TPT1) was proved to be the direct target gene of miR-1236-3p. The MTT and flow cytometry assays demonstrated that up-regulation of miR-1236-3p could markedly inhibit A549/DDP cell proliferation but promote apoptosis, which could be significantly reversed by pcDNA3.1-TPT1 plasmids. Finally, we further demonstrated that miR-1235-3p could restrain the expression levels of TPT1, Pim-3, phosphate-Bcl-2-associated death promoter (p-BAD) and B-cell lymphoma-extra large (Bcl-XL) in A549/DDP cells, while the inhibition could be reversed by pcDNA3.1-TPT1 as well. In a word, our study demonstrated that miR-1236-3p could reverse DDP resistance by modulation of TPT1 gene and inhibition of Pim-3 signaling pathway in lung cancer cells.
The link between thyroid autoimmunity, depression and bipolar disorder
Authors: Jucevičiūtė Neringa , Žilaitienė Birutė , Aniulienė Rosita , Vanagienė Virginija
Published: February 2019

Depression and bipolar disorder are two major psychiatric illnesses whose pathophysiology remains elusive. Newly emerging data support the hypothesis that the dysfunction of the immune system might be a potential factor contributing to the development of these mental disorders. The most common organ affected by autoimmunity is the thyroid; therefore, the link between autoimmune thyroid disorders and mental illnesses has been studied since the 1930s. The aim of this review is to discuss the associations between thyroid autoimmunity, depression and bipolar disorder.
Ionic transport and atomic structure of AgI-HgS-GeS2 glasses
Authors: Zaiter Rayan , Kassem Mohammad , Fontanari Daniele , Cuisset Arnaud , Benmore Chris J. , Bychkov Eugene
Published: February 2019

Quasi-ternary (AgI)
x
(HgS)0.5−

x

/2(GeS2)0.5−

x

/2 glasses, 10−4≤x≤0.6 were studied over a wide composition range covering nearly 4 orders of magnitude in the mobile cation content. The glasses show a remarkable increase of the ionic conductivity by 12 orders of magnitude and exhibit two drastically different ion transport regimes: (i) a power-law critical percolation at x≲0.04, and (ii) a modifier-controlled conductivity, exponentially dependent on x≳0.1. Using Raman spectroscopy and high-energy X-ray diffraction supported by DFT modelling of the Raman spectra we show that the glass network is essentially formed by corner-sharing CS-GeS4/2 tetrahedra. Mercury sulfide in glasses is dimorphic. The majority of Hg species (70% at x<0.2) exist as two-fold coordinated (HgS2/2)
n
chains. Silver species have mixed (2I+2S) tetrahedral environment forming either edge–sharing ES-Ag2I2S4/2 dimers or corner-sharing (CS-AgI2/2S2/2)
n
chains. The relationship between the ionic transport and atomic structure of the glasses is discussed.
Effect of aging conditions on the mechanical properties and antimicrobial activity of elastomer nanocomposites
Authors: Przybyłek Małgorzata , Białkowska Anita , Bakar Mohamed , Kosikowska Urszula , Szymborski Tomasz
Published: February 2019

The present study investigates the effect of thermooxidative and photooxidative aging on the mechanical and bactericidal properties of elastomer nanocomposites (ENs) based on Nanobent ZR2. The mechanical properties and morphologies were analyzed before and after aging. The addition of nanoparticles had a significant effect on the mechanical properties of ENs. Samples containing Nanobent exhibited higher tensile strength before and after aging compared to the reference composition. The addition of nanoparticles attenuated elastomer aging at elevated temperatures and ultraviolet light. Aged nanocomposites showed an inhibitory effect on the growth of bacteria and yeasts. Antibacterial and antifungal activity was only partially reduced after aging using physical methods compared to the activity of probes without aging. Scanning electron microscopy micrograph analysis showed different rough but homogeneous structures, confirming the uniform dispersion of the modified nanoparticles in the elastomer matrix as well as the retention of mechanical properties after the aging process.
Habituality in four Oceanic languages of Melanesia
Authors: von Prince Kilu , Krajinović Ana , Margetts Anna , Thieberger Nick , Guérin Valérie
Published: February 2019

Our knowledge about tense, aspect and modality (TMA) in the Oceanic languages of Melanesia has so far been severely limited by the lack of available data. Habituality in particular, as one of the less described TMA categories, has not yet been widely discussed for this group of languages. Based on corpus data and elicitations, we give a detailed overview of four languages, identifying common trends and addressing specific questions of general concern. These include the relation of habituality to (im)perfectivity and the relation between habituality and irrealis.
Extended conjugation in stilbenoid squaraines
Authors: Meier Herbert
Published: February 2019

Squaraines, two-fold condensation products in 1,3-position of squaric acid, represent dyes or pigments of high actuality. After their first boom in electrophotography diverse applications are presently studied in a wide area of research, which reaches from electrooptical materials to biosensors and compounds used in photodynamic therapy. Absorption and/or emission ranges in the NIR are mandatory for many of these techniques. The present article deals with stilbenoid squaraines, which feature an extended conjugation in their biradicaloid D-π-A-π-D structure. Due to the charge-transfer character of the excitation, boundaries are set for the optimal length of the conjugation. The absorption maxima of the stilbenoid squaraines and their aggregates are lying in chloroform as a solvent between 600 and 1000 nm. In the solid state panchromatic absorptions can be observed, which reach far into the NIR region. The facile preparation of squaraines bearing stilbene building blocks in one or two of their arms and moreover the easy access to dyes with multiple squaraine units fixed to stilbenoid scaffolds promise a wide palette of further applications in materials science.
Crystal structure of Sc3Co1.64In4 and Sc10Co9In20 from single-crystal data
Authors: Gulay Nataliya , Tyvanchuk Yuriy , Daszkiewicz Marek , Stel’makhovych Bohdan , Kalychak Yaroslav
Published: February 2019

Two compounds in the Sc-Co-In system were obtained by arc-melting of the pure metals and their crystal structures have been determined using single crystal X-ray diffraction data. The structure of Sc3Co1.64In4 (space group P6̅, а=7.6702(5), c=3.3595(2) Å, Z=1, R
1=0.0160, wR
2=0.0301) belongs to the Lu3Co2−

x
In4 type structure, which is closely related to the ZrNiAl and Lu3CoGa5 types. The structure of Sc10Co9In20 (space group P4/nmm, а=12.8331(1), c=9.0226(1) Å, Z=2, R
1=0.0203, wR
2=0.0465) belongs to the Ho10Ni9In20 type, which is closely related to HfNiGa2.
On the Influence of Multiple Polarization Changes on the Cumulative Deformations in Sand Under Drained High-Cyclic Loading
Authors: Wichtmann T. , Triantafyllidis T.
Published: February 2019

The effect of multiple changes of the polarization (i.e., direction) of a drained cyclic loading has been studied in about 50 triaxial tests with simultaneous harmonic oscillation of the axial and lateral stresses. A fine sand has been tested at various initial densities. Starting from the same average stress in all the tests, six different polarizations of the cycles have been applied by choosing different amplitudes and phase shifts between the axial and lateral stress components. In each test, at least 10,000 cycles have been applied. The polarization has been changed every 1,000, 2,500 or 5,000 cycles. The sequence of the polarizations has been varied from test to test. Several reference tests without polarization changes have also been performed. The test results reveal that the first change of the polarization usually leads to a temporary increase of the rate of strain accumulation. This increase depends on the angle between the subsequent polarizations, while the correlation with the density or number of cycles applied prior to the polarization change is poor. All further polarization changes have only a minor effect on the rate of strain accumulation. Consequently, the final residual strain after 10,000 cycles is only moderately increased by the multiple polarization changes. The consequences of these experimental results for a high-cycle accumulation model describing the cumulative deformations in sand under a high-cyclic loading are briefly addressed.
Kartell der Algorithmen – das Verbot wettbewerbsbeschränkenden Zusammenwirkens im Lichte fortschreitender Digitalisierung bei der Preissetzung
Authors: Dück Hermann , Mäusezahl Steffen , Symnick Inga
Published: February 2019

Die fortschreitende Digitalisierung durchdringt zunehmend das gesellschaftliche Leben und wirtschaftliche Handeln. Entscheidungen werden in vielen Bereichen durch Algorithmen ausgeführt und gesteuert. Beispielsweise können Unternehmen dank Programmcodes Preise und Mengen optimieren, während Konsumenten die Möglichkeit haben, ihre Such- und Transaktionskosten mittels Vergleichsportalen zu verringern. Für den freien Wettbewerb und das Kartellrecht im Besonderen kann der unternehmerische Einsatz von Algorithmen eine Herausforderung darstellen, wenn hierdurch ein wettbewerbsbeschränkendes Zusammenwirken begünstigt wird. Abhängig vom Einsatzgebiet und der Funktionsweise lassen sich Algorithmen in unterschiedliche Kategorien einordnen, anhand derer das Gefahrenpotenzial und mögliche Gegenmaßnahmen beurteilt werden können. Technische Entwicklungen auf dem Gebiet der Künstlichen Intelligenz (KI) lassen bereits jetzt erahnen, dass der Faktor Mensch zukünftig weiter in den Hintergrund rücken wird und Entscheidungen autonom von Algorithmen getroffen werden könnten. Um den Handlungsrahmen für Kartellbehörden zu stärken, können Aspekte wie das Feststellen des Zusammenwirkens, die Zurechnung sowie die (Umkehr der) Beweislast in Betracht gezogen werden. Für den rechtskonformen Umgang mit Algorithmen kommt es aus Sicht von Unternehmen darauf an, welche Maßnahmen erforderlich sein können, um einen Rechtsverstoß zu verhindern. Dies schließt die Überlegung ein, ob die (angemessene) Nutzung von Algorithmen (hinsichtlich Auswahl und Design) in ein Compliance-Management-System eingebettet werden kann und falls ja, ob die Rechtsordnung ein derartiges System grundsätzlich anerkennen würde.
The Vasectomy Vasectomy Contraception Method in the Area of Bulili Community Health Center at City of Palu
Authors: Nur Rosmala , Napirah Muh. Ryman , . Nafilah , . Radiah , S. Patui Nurhaya , . Larasati , Syahadat Dilla Srikandi , . Pitriani
Published: February 2019

Vasectomy method has 99% success in preventing pregnancy. Among 13 community health centers in 2017, the widest number of vasectomy contraception users recorded in Bulili Community Health Center with 37 people (57,81%). The studi aims to discover of several factors of contraception use, such as education, knowledge, and family support. This research is a descriptive quantitative. The sample of this research is 37 men, particularly husbands, who are older than 35 years old and have 2 children. In collecting the sample, this research uses total sampling method. The data collection method is done by observation and interview. Furthermore, the obtained data are analyzed statistically by showing frequency distribution in each variable. The research showed that vasectomy contraception based on education (64,9%), knowledge (89,2%), and family support (94,6%) in this area is good. Consequently, citizens are expected to willingly accept information from health worker related to men’s KB
Association between hydration status, hydration knowledge and fluid consumption during training among soccer players
Authors: Jusoh N. , Salim S.
Published: February 2019

Study Aim: The purpose of this study was to determine the correlation between hydration status, knowledge of hydration and the amount of fluid intake consumption during training among the soccer players. Material and Methods: Pre-training hydration status was measured by urine colour chart and Urine Specific Gravity (USG). A questionnaire on hydration knowledge was answered by the participants on the last day of training session. Pearson Correlation test was used to analyse the correlation between hydration status, knowledge of hydration and total amount of fluid intake among the participants. Results: The results showed that the participants were dehydrated during the three days of training. Sixty four percent of the participants had a satisfactory knowledge of hydration. However, the results indicated that the sweat loss was higher than fluid intake during the training. Pearson test revealed there were positive correlation between USG and urine colour (r=0.809, p<0.001) as well as urine colour and fluid intake (r = .424, p<0.05). Conclusions: In conclusion, the findings indicate the needs to increase awareness of pre training hydration status among the participants.
Training structure of powerlifters with regard to biological rhythms and operational functional condition
Authors: Shutova T.N. , Vysotskaya T.P.
Published: February 2019

Purpose: to develop and experimentally confirm the structure of training cycles, training load and sports results with regard to the biological rhythms and functional condition of powerlifters. Material: the study involved qualified powerlifters (n = 40). The diagnostic procedure was performed on the Omega hardware complex. Ostberg questionnaire was applied to determine the athlete’s chronotype. According to the results of the questionnaire, athletes were divided into morning, evening and mixed chronotypes. In the experimental group (N1, n = 20), intensive training was conducted at the peak of the biological rhythm. Medium and low-intensity training was performed in the phase of reducing the biorhythms activity. Standard training was performed in the control group (N2, n = 20), without regard to chronotypes. Results: it was determined that the application of non-standard means of athletes training at the peak of the biological rhythms activity and in the rising phase of the biogram significantly influences on the increase in maximum strength results. Non-standard means include Crossfit training and a reverse pyramid (the maximum weight is applied at the beginning of the training, in the subsequent approaches the weight reduces, the number of repetitions increases). It is determined the significant differences between groups in the control exercises: hanging pull-up/chin up, parallel bar dips, hanging on the crossbar. Conclusions: the training of qualified powerlifters should be based on their chronotype. The main mean of the training process optimizing of athletes should be a biogram, reflecting the physical, emotional and intellectual biological rhythm.
Online Discussion in a CALL Course for Distance Language Teachers
Authors: Son Jeong-Bae
Published: February 2019

Computer-mediated communication (CMC) is increasingly used not only in second/foreign language teaching but also in language teacher education. This study investigated distance students’ participation in an online discussion group established for an applied linguistic course entitled Computer-Assisted Language Learning (CALL). Patterns of student-student interaction and students’ attitudes toward the online discussion were identified through quantitative and qualitative analyses of the students’ postings to the discussion group, transcripts of online discussions, and students’ responses to a web-based questionnaire. The results of the study indicate that students contributed primarily in the forms of fully and partially task-focused messages while the messages mainly consisted of task-based answers and interactive contributions. Almost half of the student-student interactions involved giving on- and off-task opinions and/or ideas on particular matters. Students showed positive attitudes toward online discussions as a way of learning CALL as well as toward CMC as a means of facilitating collaborative learning. The findings suggest that online discussions are useful for CALL teacher training as they provide language teachers with practical experience of CMC and communication channels for sharing ideas, comments, questions, and resources with their fellow teachers.
Developing L2 Oral Proficiency through Synchronous CMC: Output, Working Memory, and Interlanguage Development
Authors: Payne J. Scott , Whitney Paul J.
Published: February 2019

A naturalistic experiment was conducted to test the hypothesis that synchronous computer-mediated communication (CMC) can indirectly improve L2 oral proficiency by developing the same cognitive mechanisms underlying spontaneous conversational speech. The theoretical framework guiding this inquiry consists of Levelt's (1989) model of language production augmented by concepts from Working Memory theory. The findings show a significant difference between the experimental and control groups oral proficiency development with participants in the experimental condition (two of four contact hours per week were in a chatroom) scoring higher than participants in the control condition. Implications for language instruction and the second language oral proficiency development for different types of learners are discussed.
New records of thrips species on mango and natural enemies associated
Authors: Matos Sidnéia Terezinha Soares de , Andrade Daniel Júnior de , Zanata Renan Moisés Paneghini , Azevedo Emiliano Brandão de , Lima Élison Fabrício Bezerra
Published: February 2019

Abstract The mango tree (Mangifera indica L.), native to Asia, is expanding in Brazil. However, research related to phytophagous organisms and natural enemies associated with this fruit are scarce in the country. The aim of this work was to report new species of thrips-pest and natural enemies associated with mango tree inflorescence. The work was carried out in a Tommy Atkins mango orchard located in the municipality of Jardinópolis, São Paulo, Brazil. The arthropods found in malformed inflorescences were collected and identified. Frankliniella gemina Bagnall, Frankliniella distinguenda Bagnall (Thysanoptera: Thripidae) and Haplothrips gowdeyi (Franklin) (Thysanoptera: Phlaeothripidae) thrips-pest species were recorded for the first time associated with inflorescence in mango orchards. The predators were collected in association with the phytophagous thrips.
Perspectives in veterinary medicine on the use of cannabinoids as complementary palliative therapy for pain in cancer patients
Authors: Repetti Cláudia Sampaio Fonseca , Girio Raul José Silva , Friolani Milena , Barbalho Sandra Maria
Published: February 2019

ABSTRACT: Pain in the cancer patient is an important clinical manifestation that results in low life expectancy and poor prognosis. Pain may be related to tumor type, invasion of adjacent tissues, metastasis, and diagnostic and therapeutic procedures with variable response to analgesic therapy. Many studies have called attention due to their potential therapeutic effect in the modulation of pain and inflammation. Cannabinoid derivatives are chemical compounds obtained from Cannabis that act on specific receptors.Several commercial products have already been approved in Europe and the USA for use in human patients. The present study aimed to review articles on the use of cannabinoids in the control of pain contributing to the well-being and quality of life in cancer patients undergoing palliative care. Although, there are few reports in the veterinary medical literature on the use of cannabinoids in the control of pain in dogs, it is believed that such patients can benefit from this therapeutic modality.
Breastfeeding knowledge and relation to prevalence
Authors: Suárez-Cotelo María del Carmen , Movilla-Fernández María Jesús , Pita-García Paula , Arias Betty Fernández , Novío Silvia
Published: February 2019

ABSTRACT Objective: Determine the level of knowledge about maternal breastfeeding and analyze to what extent this influences the intention to breastfeed after the introduction of infant feeding at the 6th and 16th weeks and at 6 months postpartum. Method: Prospective descriptive study conducted with pregnant women in Galicia (Spain). By means of a self-filling questionnaire, data were collected on the intention of the woman to feed the newborn and their knowledge about breastfeeding. Pregnant women were also contacted at the 6th and 16th weeks and at 6 months postpartum to know the type of feeding they gave their child. Results: 297 pregnant women participated in the study, of which 90.4% wanted to exclusively breastfeed their baby, however, only 28.2% continued up to 6 months. The level of knowledge about breastfeeding was regular and it was observed that it influences both the intention and the type of feeding of the newborn, thus it is an element to be considered when developing educational strategies aimed at increasing breastfeeding rates. Conclusion: The level of pregnant women’s knowledge about breastfeeding is regular and influences the choice of how to feed their babies and the duration of exclusive breastfeeding. Strategies should be implemented to increase knowledge and improve breastfeeding rates.
Hospital Volume Versus Good Clinical Practice
Authors: Valenti Vicente
Published: February 2019

This letter to the editor comments on a recently published article that assessed the treatment of patients with soft tissue sarcoma in high-volume versus low-volume centers.
Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Opportunities and Challenges
Authors: Liu Xiufeng , Qin Shukui
Published: February 2019

Hepatocellular carcinoma (HCC) is the most common malignancy worldwide, and is especially common in China. A total of 70%–80% of patients are diagnosed at an advanced stage and can receive only palliative care. Sorafenib has been the standard of care for a decade, and promising results for regorafenib as a second-line and lenvatinib as a first-line treatment were reported only 1 or 2 years ago. FOLFOX4 was recently recommended as a clinical practice guideline by the China Food and Drug Administration. All approved systemic therapies remain unsatisfactory, with limited objective response rates and poor overall survival. Immune checkpoint inhibitors (CPIs) offer great promise in the treatment of a rapidly expanding spectrum of solid tumors. Immune checkpoint molecules are involved in almost the whole process of viral-related hepatitis with cirrhosis and HCC and in the most important resistance mechanism of sorafenib. The approval of nivolumab by the U.S. Food and Drug Administration on September 23, 2017, for the treatment of patients with HCC, based only on a phase I/II clinical trial, is a strong hint that immunotherapy will introduce a new era of HCC therapy. CPI-based strategies will soon be a main approach in anticancer treatment for HCC, and we will observe the rapid advances in the therapeutic use of CPIs, even in an adjuvant setting, with great interest. How shall we face the opportunities and challenges? Can we dramatically improve the prognosis of patients with HCC? This review may provide some informed guidance.
Dynamic properties of a sand–nanoclay composite
Authors: Ochoa-Cornejo Felipe , Bobet Antonio , Johnston Cliff , Santagata Marika , Sinfield Joseph V.
Published: February 2019

The paper describes the influence of 1–3% (by dry mass of sand) Laponite, a highly plastic synthetic nanoclay, on the dynamic properties of Ottawa sand, based on undrained resonant column tests. The effect of Laponite depends on the amount added, the confining stress and consolidation time. With 1% Laponite, there is an increase in the very small-strain shear stiffness at all confining stresses, which increases with extended consolidation time, reflecting the thixotropic nature of the nanoclay. Added Laponite also produces an increase in small-strain damping, an extension of the linear strain threshold; and it delays the generation of excess pore pressure, degradation of shear modulus and increase in damping with shear strain. These effects, which become more significant with increasing Laponite content, can be attributed to the impact of the clay on the fabric and grain-to-grain contacts. Evidence is provided that Laponite interferes with direct interaction between the sand grains, and the thickness of the clay layer present at the contacts appears to control the small-strain behaviour of the sand–Laponite mixtures. The formation of a gel-like pore fluid from the hydration of Laponite in the voids, and the degree to which it occupies the pore space, are responsible for the behaviour in the non-linear region.
Ken Foster and the Genesis of Sports Law: A Personal Perspective
Authors: Boyes Simon
Published: February 2019

Ken Foster’s work in the field of sports law is of central importance. His sustained, high-quality contributions to sports law scholarship underpin much other work in the area. This intervention makes the case for the importance and centrality of this work, and highlights key contributions. It evidences the development of key themes and perspectives in Ken Foster’s work and its fundamental and foundational significance in the relatively new field of sports law.
Comunidades virtuales de viajeros: un caso de éxito
Authors: Cervi Laura
Published: February 2019

Este artículo se propone estudiar la comunidad italiana de viajeros on line Ho sempre voglia di partire que, en solo dos años de vida, cuenta con más de 540 000 seguidores, más de 7 000 000 de visitas por mes y 2 700 000 interacciones. El objetivo es describir las interacciones presentes en la comunidad para desvelar las razones por las cuales los usuarios participan, los beneficios, reales y simbólicos que obtienen, y poder comprender las razones del éxito. A través de una triangulación de métodos el artículo desvela como la clave de todas las interacciones es la emoción y que, por lo tanto, los beneficios que los miembros obtienen son principalmente emocionales.
Trabajo rural entre adultos y jóvenes asalariados rurales en Uruguay
Authors: Romero Cabrera Juan Ignacio
Published: February 2019

En los últimos diez años en el Cono Sur latinoamericano incluido Uruguay, se han realizado importantes inversiones en el rubro agropecuario por parte de corporaciones agroalimentarias globales se destacan en la soja, forestal, minerales, caña de azúcar, carnes, etc. Se ha desarrollado la reconfiguración del espacio social rural en diferentes dimensiones de análisis, una de ellas es el mercado de trabajo. En tal sentido, se plantea analizar las principales características del mercado de empleo rural, condiciones sociales de los asalariados rurales por medio de las categorías de R. Kaztman y cuatro dimensiones del empleo decente: contexto socioeconómico, oportunidad de empleo, seguridad social e ingresos monetarios tal análisis se realiza de forma transversal desde el enfoque de generaciones. Los datos estarían indicando condiciones sociales de desigualdad e inequidad en el trabajo según el grupo generacional del asalariado. El análisis por medio de la dimensión generacional señala al mismo conformando un “nodo” en la configuración de la desigualdad social de la sociedad rural.
Micro-política de una escuela marginalizada: entre inclusión y estandarización
Authors: Armijo Cabrera Muriel
Published: February 2019

En el marco de la Ley de Inclusión (20.845/2015) que promueve la mixtura social de los estudiantes chilenos, se indaga una escuela subvencionada en contexto de pobreza que ha promovido esta mixtura desde su creación en 1980, al ser gratuita y sin selección. Se busca entender cómo se despliegan los procesos de inclusión/exclusión social de las niñas y los niños en este escenario de marginalidad. ¿Qué significa entonces “incluir”? ¿Cuáles son las fronteras entre inclusión y exclusión social en la escuela? Se realiza una etnografía escolar interpretativa durante 7 meses, con un foco en un curso de 4º básico. Los primeros hallazgos de campo se centran en la micro-política de la escuela (Ball, 1987). Se identifican tres dispositivos principales: un dispositivo identitario, que descansa en el ethos histórico de la escuela y su proyecto de inclusión social; un dispositivo tradicional, que recoge las trayectorias culturales de los sujetos y las representaciones presentes en la sociedad; un dispositivo tecnocrático, que se instala progresivamente desde el sistema educativo en pos de una estandarización del proceso educativo. Durante el proceso investigativo, se observa la evolución del equilibrio entre los tres dispositivos en la escuela, dónde las finalidades éticas de inclusión están superadas por los objetivos tecnocráticos de estandarización. Se evidencian prácticas pedagógicas cooperativas existentes en la escuela que van desapareciendo en beneficio de tecnologías de clasificación y estrategias competitivas.
Comunicación digital en desarrollo turístico de la Isla Puná, Ecuador
Authors: Andrade Mendoza Karen Indira
Published: February 2019

Este estudio pretende exponer la importancia de la comunicación digital e intercultural tanto para la conservación de los recursos naturales y la preservación del patrimonio cultural, como también la comunicación es prioritaria para potencializar actividades de desarrollo económico y social como el turismo, esto a través del reconocimiento y visualización de las comunidades por parte un público más amplio, con el uso de las diversas herramientas comunicativas que provee el internet y los espacios mediáticos.

 Además, se caracterizará la riqueza natural y cultural existente en la Isla Puná, como artífice para un proceso de difusión de información y de ampliación de los canales de comunicación entre los diversos sectores productivos, sociales y culturales presentes en las dinámicas poblacionales de sus ciudadanos que la habitan.
Loop and uLoop assembly v3
Authors: Pollak Bernardo
Published: February 2019

This protocol is used for performing Type IIS assembly by either BsaI or SapI-mediated restriction/ligation using Loop assembly with either Loop or uLoop plasmids. Loop assembly comprises8receiver plasmids in odd and even levels (4 per level), which containdirectional overhangs for higher level assembly. Odd and even level receiver plasmids are used in a recursive schemafor assembly initerative 'loops'. Any assembly (except for L0 part composition into a L1 transcriptional unit) requires the usage of 4 donorplasmids (each ina specific position) and one receiver plasmid. BsaI is used for assembly into odd levels using kanamycin selection, and SapI is used in even levels using spectynomycin selection.Loop odd receivers use theCommon Syntax standard for L0 part assembly into TUs (Patron,et al.2015 [10.1111/nph.13532]). Then, 4 L1 plasmids (positions 1-4) are assembled into aneven receiver plasmid to provide a L2 assembly (4 TUs). For higher level assemblies the same assembly structure is followed, 4 L2 plasmids (positions 1-4)with anodd receiver to yield a L3 assembly (16 TUs). TheLoop type IIS assembly protocol is based on: “Patron, NJ (2016) DNA Assembly for Plant Biology. Current Protocols in Plant Biology 1:1-13 [doi: 10.1002/cppb.20038]”, but with slight modifications for DNA concentrations: Thisprotocol uses a target amount of each donor DNA of 15 fmol and 7.5 fmol forreceiver plasmid DNA in a 10 µL reaction. In order to performaccurate dispensing, the plasmid DNA is diluted to their correspondingconcentration of 15 fmol/µL for donor parts and of 7.5 fmol/µL for the receiver plasmid, and then 1 µL of each plasmid is added to the DNA mix.Theplasmid part target concentration(in ng/uL) equals to eachdonor plasmid length / 100, and of the receiver plasmid length / 200. Volumes CAN be reduced by half, but expect more variability from aliquoting.
Romania in the Second World War 1939–1945: unknown facts and new views on the problem
Authors: Luchkanyn Serhii
Published: February 2019

The article is devoted to the analysis of different views in Romanian historiography on the participation of I. Antonescu, along with Germany, Italy, Hungary, Slovakia and Finland, in the war against the USSR, starting from June 22, 1941.

It is known that the decision to join the anti-Soviet war was taken by I. Antonescu alone, without any consultation with any political group, or even with the king Mihai, who has learned from the BBC radio that Romania had entered the war with the USSR. First, the war was proclaimed as a “sacred war” against Bolshevism for the return of Bessarabia and Northern Bukovina, received full support from the king and from the leaders of the “historical parties”, as well as from a wide range of the population. However, in August 1941, at the request of Hitler, having already military rank of Marshal, Ion Antonescu decided to continue the war in the East, which has been completely unfounded (the territory to the East of the Dniester never belonged to Romania). The modern Romanian historiographers emphasize that the continuation of the anti-Soviet war on the other side of the Dniester, which led to large (and useless) human losses, has become one of Antonescu’s greatest mistakes. The article also raises the issue of the Holocaust in Romania during the Second World War (suppressed during the communist years), the decline in the scale of the tragedy in that period. It is noted that the arrest of I. Antonescu on August 23, 1944 was the merit of the young king, Mihai I, and his entourage, and not the Communist Party of Romania represented by Lucreţiu Pătrăşcanu.
The Formation and the Evolution of the British Labour Party
Authors: Buturlimova Olha
Published: February 2019

The article examines the processes of organizational development of the British Labour Party in the early XXth century, the evolution of the party structure and political programme in the twentieths of the XXth century. Special attention is paid to researching the formation of the Social Democratic Federation, Fabian Society and Independent Labour Party till the time of its joining to the Labour Representation Committee in 1900 and adopting the “Labour Party” name in 1906. The author’s aim was to comprehensively investigate the political manifests and activities of those organizations on the way of transformation from separate trade-unions and socialist groups to apparent union of labour, and then to the mass and wide represented parliamentary party. However, the variety of social base of those societies is distinguished, and difference of socialist views and tactics of achieving the final purpose are emphasized. Considerable attention is paid to the system of the individual membership and results thereof in the process of the evolution of the Labour Party’s organization. The reorganization of the Labour party in 1918, Representation of the People Act, 1918 and the crisis in the Liberal party were favourable for the further evolution of the Labour Party. It is summarized that the social base, the history of party’s birth, the conditions of formation and the party system had influenced the process of the evolution of the ideological and political concepts of Labourizm.
OPTIMIZATION BUSINESS PROCESSES FOR TRANSITION TO A SUSTAINABLE DEVELOPMENT IN THE CONDITIONS OF THE FOURTH INDUSTRIAL REVOLUTION
Authors: Lisovsky A. L.
Published: February 2019

The influence of technologies of the Industry 4.0 on optimization business processes of the industrial companies for achievement of a sustainable development is analyzed. Effects of the changes caused by technologies of the Industry of 4.0 in the Russian and foreign companies are considered. It is shown that achievement of a sustainable development is impossible without the process innovations caused by introduction of new technologies. The algorithm of carrying out audit and an assessment of the new technologies “business processes” most ready to introduction is offered for their introduction..
TEKNIK PENGUJIAN KEAMANAN DATA TEXT BERTINGKAT DENGAN METODE STEGANOGRAPHY LSB DAN TEKNIK ENKRIPSI
Authors: Damanik Hillman Akhyar , Anggraeni Merry
Published: February 2019

Internet adalah media komunikasi paling populer saat ini, tetapi komunikasi melalui internet menghadapi beberapa masalah seperti keamanan data, kontrol hak cipta, kapasitas ukuran data, otentikasi dan lain sebagainya. Pada penelitian ini peneliti memperkenalkan skema untuk menyembunyikan data yang terenkripsi. Dengan menggunakan citra sebagai embedding dan cover image untuk text hiding. Fitur utama skema adalah cara penyematan data teks ke cover image terenkripsi. Peneliti berkonsentrasi menggunakan metode Red-Green-Blue Least Significant Bit (RGB-LSB). Penyematan data teks dan memverifikasi kinerja menggunakan metode RGB-LSB dalam hal indeks kualitas yaitu Peak Signal-to-Noise Ratio (PSNR) dan Mean Square Error (MSE) , imperceptibility dan indeks recovery. Nilai SME pada jumlah pesan yang disisipi sebanyak 407 kata adalah nilai MSE 0.8310 dan nilai PSNR 48.9348. pada jumlah pesan yang disisipi sebanyak 507 kata adalah nilai MSE 0.8322 dan nilai PSNR 48.9285. Nilai kriteria imperceptibility pada stego image menghasilkan image dan nilai-nilai pixel pada masing-masing cover image tidak mengalami perubahan. Aspek recovery pada penyembunyian pesan teks pada masing-masing cover image pada proses embedding, dimensi citra yang berbeda dan sampai proses ekstraksi juga menghasilkan panjang pesan asli terungkap. Berdasarkan hasil perbandingan ini dapat diketahui bahwa algoritma LSB memiliki hasil yang baik pada teknik penyisipan sebuah pesan pada file citra.
EVALUASI TATA KELOLA TEKNOLOGI INFORMASI E-KTP MENGGUNAKAN FRAMEWORK COBIT (STUDI KASUS : DINAS KEPENDUDUKAN DAN CATATAN SIPIL KABUPATEN BOGOR)
Authors: Kurniawan Dwi Tjahyo
Published: February 2019

Dinas Kependudukan dan Catatan Sipil Kabupaten Bogor (Disdukcapil) bertugas menjalankan sistem kependudukan elektronik kartu identitas (e-KTP). Metodologi yang digunakan berdasarkan kerangka  kerja Control Objectives for Information and related Technology (COBIT) 4.1. COBIT merupakan framework yang menjembatani kesenjangan antara risiko dan masalah bisnis dengan teknis sehingga sistem informasi teknologi e-KTP berjalan sangat. Hasil analisis yang dilakukan di Dinas Kependudukan dan Catatan Sipil Kabupaten Bogor (Disdukcapil) menghasilkan nilai 2,48 yang berarti pada tingkat 2 (dapat diulang). Dinas Kependudukan dan Catatan Sipil Kabupaten Bogor telah memiliki pola untuk mengelola proses  terkait  berdasarkan keberhasilan  pengalaman  yang  berulang  yang  pernah  dilakukan sebelumnya  tetapi pola yang dilakukan belum berstandar. Hasil tersebut menjadi dasar penentuan analisis gap serta rekomendasi yang  diperlukan berdasarkan  standar  COBIT untuk Disdukcapil.
A New Game in Town: Disseminating Sports Content in a Net Neutrality-Less Era—The Potential Implications for the Post-Broadcasting World
Authors: Conrad Mark
Published: February 2019

The Federal Communications Commission’s (FCC) repeal of the net neutrality rules has implications for the consumers of program content found on broadband internet service providers (ISPs). Under the former rule, such providers cannot engage in discrimination by favoring some content over others or by using their broadband to speed up favored content or slow down less favored content (practices known as “throttling”). With the demise of net neutrality, ISPs have the power to control what viewers see and how they see it, with few resources to fight such decisions. One key programming category is sports. The end of net neutrality can have an adverse impact to sports streams, because of the high amounts of broadband space and the rapid consolidation between sports content providers and ISPs. This article discusses the background of the powers of the FCC, the history of the net neutrality rules, the FCC’s 2018 order repealing the rules, and the legal and political reactions to it. It concludes by raising a number of hypothetical situations where the lack of net neutrality can have an adverse impact for consumers of sports material.
Problematizing Disability Disclosure in Higher Education: Shifting Towards a Liberating Humanizing Intersectional Framework
Authors: Pearson Holly , Boskovich Lisa
Published: February 2019

Disability disclosure contains significant implications when considering democratic educational opportunities for students with disabilities in higher education. Especially for graduate students with disabilities, there is minimal research on their experiences with disability disclosure. In a collaborative autoethnography, two doctoral students with disabilities engage in a critical dialogue about how disability disclosure operates within everyday interactions. Through dialogue and praxis, our narratives highlight how acts of disability disclosure continuously construct the notion of disability, democracy, citizenship, and empowerment in higher education. In turn, critical reexaminations of disability disclosure may present insight into future directions that will ensure equal educational opportunities, attainment and achievements for all.
Enginar Yaprağı Sulu Ekstraktı Kullanılarak Çinko Oksit Nanopartiküllerinin Yeşil Sentezi, Karakterizasyonu, Anti-Bakteriyel ve Sitotoksik Etkileri
Authors: ERDOĞAN Ömer , BİRTEKOCAK Fatih , ORYAŞIN Erman , ABBAK Mürüvvet , DEMİRBOLAT Gülen Melike , PAŞA Salih , ÇEVİK Özge
Published: February 2019

Amaç: Bu çalışmanın amacı, yeşil kimya yöntemiyle çinko oksit nanopartiküllerini (ZnONPs) sentezlemek ve bu nanopartiküllerin anti-bakteriyel ve anti-kanser etkilerini incelemektir.Gereç ve Yöntemler: Çinko iyonları ve sulu enginar yaprağı (Cynara scolymus) ekstraktı kullanılarak ZnONPs yeşil kimya yöntemiyle sentezlendi. ZnONPs oluşumunun doğrulanması ve karakterizasyonu için morötesi-görünür bölge spektroskopisi (UV-Vis), Fourier dönüşümü kızılötesi spektroskopisi (FTIR), taramalı elektron mikroskobu (SEM), zetasizer ve Enerji dağınım X-ışını spektroskopisi (EDX) analizleri kullanıldı. ZnONPs’nin 4 farklı bakteri türü (E. coli, S. aureus, P. aeruginosa ve E. faecalis) üzerindeki antibakteriyel aktiviteleri, minimal inhibe edici konsantrasyon (MİK) ve kuyucuk difüzyon yöntemiyle ölçüldü. ZnONPs’nin HT-29 insan kolon kanseri hücreleri üzerindeki sitotoksik etkileri konsantrasyon ve zamana bağlı olarak olarak belirlendi.Bulgular: UV-Vis spektrumunda ZnO’ya spesifik olan 320-335 nm aralığında absorbans artışı gözlemlendi. FTIR spektrumunda 426 cm-1 ve 540 cm-1’de ZnO’ya ait gerilme titreşimleri belirlendi. SEM analizinde partikül boyutu 276-309 nm ölçüldü. ZnONPs’nin zeta-sizer analizlerinde partikül büyüklüğü 137,8 nm ve partikül yükü -6,34 meV olarak bulundu. Antibakteriyel aktivite ölçümlerinde, sentezlenen nanopartiküllerin E. coli ve S. aureus’ta bakteriyel aktivite inhibisyonu sağladığı tespit edildi. ZnONPs HT-29 kolon kanseri hücreleri üzerinde 10 µg/mL’den daha yüksek konsantrasyonlarda sitotoksik etki gösterdi.Sonuç: ZnONPs’nin düşük maliyetle hazırlanabileceği ve klinik tedavilerde yeni ilaç formülasyonları için taşıyıcı sistem olarak kullanılma potansiyeline sahip olduğu bu çalışma ile gösterilmiştir.
Ciencias animales, transferencia de tecnología y educación veterinaria
Authors: Villamil Jiménez Luis Carlos
Published: February 2019

La dirección de la investigación en producción animal, la transferencia de tecnología ligada al crédito de fomento y el manejo de los recursos para el sector constituyen aspectos prioritarios en el agro colombiano. Juan José Salazar Cruz realizó una labor pionera en esos campos durante más de cuarenta años de actividad profesional. Contribuyó con el inicio de la investigación en ciencias animales en el Instituto Colombiano Agropecuario (ICA), el lineamiento de políticas de transferencia de tecnología y el fomento ganadero en la Caja de Crédito Agrario Industrial y Minero; así también, en la sanidad animal como gerente de VECOL, en la financiación de la producción agraria desde la gerencia del Fondo Financiero Agropecuario, en la educación en la Universidad de La Salle, impulsando el desarrollo del nuevo programa de Medicina Veterinaria, y desde el Instituto Interamericano de Cooperación para la Agricultura como representante ante el gobierno de México. En estas notas se describen sus experiencias y logros, como un ejemplo para las nuevas generaciones de profesionales de la salud y la producción animal en Colombia.
La formación frente a los cambios de la sociedad contemporánea colombiana
Authors: Coronado Padilla, FSC Hermano Fabio Humberto
Published: February 2019

El programa de Licenciatura en Educación Religiosa llega a sus cincuenta años de trayectoria (1968-2018). Una tradición cincuentenaria que inicia el 7 de octubre de 1968 cuando el Consejo Directivo de la Universidad Social Católica de La Salle expide el acuerdo No 21 por el cual se funda la Facultad de Pastoral Catequética. En la coyuntura de esta efeméride, la presente Lectio Inauguralis discurre sobre tres de los cambios de la sociedad contemporánea colombiana más influyentes en las instituciones educativas: la libertad de cultos, la concepción de familia y los derechos de la población LGBTI. Estos son analizados desde el concepto de formación y sus repercusiones en la acción formadora-transformadora de los maestros, particularmente en los responsables de la comunicación de la fe a los ciudadanos de una Colombia multicultural y plurirreligiosa.
Educación disruptiva en el contexto lasallista: glosas para la discusión
Authors: Molano Camargo Milton
Published: February 2019

Este artículo plantea la reflexión en torno a las relaciones de los usos tecnológicos en educación a partir de tres aspectos: el primero, la pregunta acerca de lo disruptivo en educación en medio de las tendencias contemporáneas que plantean la necesidad de rupturas radicales y de la construcción de propuestas por fuera de la tradición; el segundo, reflexionar sobre los impactos innovadores que la propuesta lasallista trajo al mundo de la educación y las tecnologías empleadas en esa empresa; el tercero, revisar algunas cautelas que valdría la pena tener en cuenta en la incorporación de las nuevas tecnologías de la información y la comunicación en los procesos educativos y en su sustentabilidad.