bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism of metamifop resistance in Digitaria ciliaris var. chrysoblephara from Jiangsu, China
Authors: Cao Jingjing , Tao Yuan , Zhang Zichang , Gu Tao , Li Gui , Lou Yuanlai , Wang Hongchun
Published: February 2023

Digitaria ciliaris var. chrysoblephara is one of the most competitive and problematic grass weeds in China. Metamifop is an aryloxyphenoxypropionate (APP) herbicide that inhibits the activity of acetyl-CoA carboxylase (ACCase) of sensitive weeds. Following the introduction of metamifop to China in 2010, it has been continuously used in rice paddy fields, thereby substantially increasing selective pressure for resistant D. ciliaris var. chrysoblephara variants. Here, populations of D. ciliaris var. chrysoblephara (JYX-8, JTX-98, and JTX-99) were observed to be highly resistant to metamifop, with resistance index (RI) values of 30.64, 14.38, and 23.19, respectively. Comparison of resistant and sensitive population ACCase gene sequences revealed that a single nucleotide substitution from TGG to TGC resulted in an amino acid substitution from tryptophan to cysteine at position 2,027 in the JYX-8 population. No corresponding substitution was observed for JTX-98 and JTX-99 populations. The ACCase cDNA of D. ciliaris var. chrysoblephara was successfully obtained by PCR and RACE methods, representing the first amplification of full length ACCase cDNA from Digitaria spp. Investigation of the relative expressions of ACCase gene revealed the lack of significant differences between sensitive and resistant populations before and after herbicide treatments. ACCase activities in resistant populations were less inhibited than in sensitive populations and recovered to the same or even higher levels compared to untreated plants. Whole-plant bioassays were also conducted to assess resistance to other ACCase inhibitors, acetolactate synthase (ALS) inhibitors, auxin mimic herbicide, and protoporphyrinogen oxidase (PPO) inhibitor. Cross-resistance and some multi-resistance were observed in the metamifop-resistant populations. This study is the first to focus on the herbicide resistance of D. ciliaris var. chrysoblephara. These results provide evidence for a target-site resistance mechanism in metamifop-resistant D. ciliaris var. chrysoblephara, while providing a better understanding of cross- and multi-resistance characteristics of resistant populations that will help in the management of herbicide-resistant D. ciliaris var. chrysoblephara.
Bottom-up transdiagnostic personality subtypes are associated with state psychopathology: A latent profile analysis
Authors: Soodla Helo Liis , Akkermann Kirsti
Published: February 2023

Introduction

Personality-based profiling helps elucidate associations between psychopathology symptoms and address shortcomings of current nosologies. The objective of this study was to bracket the assumption of a priori diagnostic class borders and apply the profiling approach to a transdiagnostic sample. Profiles resembling high-functioning, undercontrolled, and overcontrolled phenotypes were expected to emerge.

Methods

We used latent profile analysis on data from a sample of women with mental disorders (n = 313) and healthy controls (n = 114). 3–5 profile solutions were compared based on impulsivity, perfectionism, anxiety, stress susceptibility, mistrust, detachment, irritability, and embitterment. The best-fitting solution was then related to measures of depression, state anxiety, disordered eating, and emotion regulation difficulties to establish clinical significance.

Results

A 5-profile solution proved best-fitting. Extracted profiles included a high-functioning, a well-adapted, an impulsive and interpersonally dysregulated, an anxious and perfectionistic, and an emotionally and behaviorally dysregulated class. Significant differences were found in all outcome state measures, with the emotionally and behaviorally dysregulated class exhibiting the most severe psychopathology.

Discussion

These results serve as preliminary evidence of the predictive nature and clinical utility of personality-based profiles. Selected personality traits should be considered in case formulation and treatment planning. Further research is warranted to replicate the profiles and assess classification stability and profiles’ association with treatment outcome longitudinally.
An experimental study on grammatical sensitivity and production competence in Chinese and Spanish EFL learners and its implications on EFL teaching methods
Authors: He Qiaoling , Oltra-Massuet Isabel
Published: February 2023

Implicit knowledge acquired by L2 learners determines their language competence; however, it remains an issue to what extent advanced EFL learners can acquire implicit language knowledge. This study aims at finding out whether advanced EFL learners from two different L1s could acquire a level of implicit knowledge of English questions by using the modified Elicited Oral Imitation Task. A quantitative, experimental study with the Elicited Oral Imitation Task experimental tool was designed. A total number of 91 participants were recruited via the online experimental platform from October to November, 2021, distributed into a native speaker group, a Chinese EFL learner group, and a Spanish EFL group. The study evaluated participants’ implicit language knowledge by assessing two indicators: the grammatical sensitivity index and the production index. Independent-sample t-test and one-way analysis of variance (ANOVA) were applied to examine the differences in the two indices among different groups. Results revealed that both EFL groups displayed a significant difference with the native speaker group in their degree of implicit knowledge of English questions in general. A further comparison of the two indicators showed that while both EFL groups displayed a relatively high grammatical sensitivity to morpho-syntactic errors in English questions, their corrective production rate of ungrammatical sentences was notably lower. These results indicate that advanced EFL learners had difficulty in acquiring implicit knowledge of English questions at native speaker’ level. These findings also imply a gap between EFL learners’ language knowledge level and corresponding language production competence. Targeting this gap within the Interaction-based production-oriented approach pedagogical implications based on were suggested for enhancing EFL learners’ language production competence in EFL contexts.
Translation directionality and translator anxiety: Evidence from eye movements in L1-L2 translation
Authors: Jia Juan , Wei Ziyu , Cheng Heben , Wang Xiaolu
Published: February 2023

While considerable research on the impact of anxiety on second language learning has been carried out in international contexts, the impact of anxiety on the translator’s undertaking L2 translation, a sort of anxiety arising from the translation directionality, as well as the structure of cognitive mechanism for translational anxiety, remain under-explored. Adopting the eye-tracking and key-logging approach to data collection, this study implemented an eye-tracking experiment with EFL learners at a Chinese university to probe into how the participants responded to L1 and L2 translation-tasks and the mechanism involved in these processes. It is found that translation directionality does have a great impact on the processing of translation, which causes the change of cognitive load and then leads to the change of levels in translator anxiety. The finding further confirms the key premises of the Processing Proficiency Model and the Revised Hierarchical Model with attendant implications for translation processes.
Illegal drug use is associated with poorer life satisfaction and self-rated health (SRH) in young people
Authors: Kang Weixi
Published: February 2023

Illegal drugs can bring negative health and psychological health consequences to people who use them. However, much less is known about illegal drug use and its association with life satisfaction and self-rated health (SRH) in young people in the context of the United Kingdom, which is important because SRH and life satisfaction are associated with important outcomes including morbidity and mortality. By analyzing data from a nationally representative sample with 2,173 people who do not use drugs and 506 people who use illegal drugs aged between 16 and 22 (mean = 18.73 ± 1.61) years old from Understanding Society: the UK Household Longitudinal Study (UKHLS) using a train-and-test approach and one-sample t-tests, the current study found that illegal drug use is negatively associated with life satisfaction (t(505) = −5.95, p < 0.001, 95% CI [−0.58, −0.21], Cohen’s d = −0.26) but not with SRH. Intervention programs and campaigns should be developed to prevent people from using illegal drugs, which may then avoid the negative consequence of poor life satisfaction associated with illegal drug use.
Short-term exposure of PM2.5 and PM10 increases the number of outpatients with eczema in Guangzhou: A time-series study
Authors: Zhang Ji , Yang Yicheng , Fu Lin , Jing Dian , Sun Bo , Chen Yilin , Chen Junyi , Shen Shuqun
Published: February 2023

Background

The worldwide prevalence of eczema has continued to rise over the past decades. This has led to the emphasis on the association between air pollution and eczema. This study investigated the relationship between daily exposure to air pollution and the number of eczema outpatient visits in Guangzhou with the overarching goal of providing novel insights on the interventions for eczema aggravation and prevention.

Methods

Daily air pollution data, meteorological data, and the number of eczema outpatients were obtained from 18 January 2013 to 31 December 2018 in Guangzhou. A generalized additive model with Poisson distribution was used to assess the association between the number of eczema outpatient visits and short-term exposure to PM2.5 and PM10. In addition, the association of PM2.5 and PM10 by age (<65 years, ≥65 years) and gender was evaluated.

Results

A total of 293,343 eczema outpatient visits were recorded. The obtained results indicated that a 10 μg/m3 increase of the same day/lag 1 day/lag 2 days PM2.5 was associated with increments of 2.33%, 1.81%, and 0.95% in eczema outpatient risk, respectively. On the other hand, a 10 μg/m3 increase of PM10 was associated with eczema outpatients risk increments of 1.97%, 1.65%, and 0.98% respectively. Furthermore, the associations of PM on the increment of eczema were similar in the male and female groups. Results obtained after age stratified analyses indicated that the strongest positive association between PM2.5 exposure and eczema was observed at lag 0 day with the percent changes being 4.72% and 3.34% in <12 years old, ≥12 and <65 years old, and ≥65 years old groups, respectively.

Conclusion

Short-term exposure to PM2.5 and PM10 increases the number of eczema outpatients, especially among children and the elderly. The relationship between air quality trends and hospital resource arrangement should be paid attention to by hospital managers which may aid in disease prevention and lower the health burden.
Prevalence and associated factors of recurrent pregnancy loss in Nigeria according to different national and international criteria (ASRM/ESHRE vs. WHO/RCOG)
Authors: Eleje George Uchenna , Ugwu Emmanuel Onyebuchi , Igbodike Emeka Philip , Malachy Divinefavour Echezona , Nwankwo Ekeuda Uchenna , Ugboaja Joseph Odirichukwu , Ikechebelu Joseph Ifeanyichukwu , Nwagha Uchenna Ifeanyi
Published: February 2023

Background

In low-and middle-income countries, no conclusive research explains the prevalence and associated factors of women with a history of recurrent pregnancy loss (RPL). Some authorities have recommended further scientific research on the effect of various definitions of RPL.

Objective

To assess prevalence and associated factors of RPL among pregnant women in Nigeria according to different national and international criteria: the American Society for Reproductive Medicine/ European Society for Human Reproduction and Embryology (ASRM/ESHRE; two losses) and the World Health Organization/ Royal College of Obstetricians and Gynecologists (WHO/RCOG; three consecutive losses) criteria.

Methods

This is a cross-sectional analytical study wherein, pregnant women with prior RPL were investigated. The outcome measures were prevalence and risk factors. The associations between independent variables and outcome variable were explored using bivariate and multivariable logistic regression models. The results of these analyses were reported as adjusted odds ratios (AORs) with 95% confidence intervals (95%CI). Factors associated with RPL were identified using multivariate regression models.

Result

Of the 378 pregnant women interviewed, the overall prevalence of RPL in this study was found to be 15.34% (95% confidence interval = 11.65%–19.84%). The prevalence of RPL was 15.34% (58/378; 95%CI = 11.65%–19.84%) and 5.29% (20/378; 95%CI = 3.23%–8.17) according to the ASRM and the WHO criterion respectively. Regardless of diagnostic criteria, unexplained (AOR = 23.04; 95%CI: 11.46–36.32), endocrine disturbances (AOR = 9.76; 95%CI: 1.61–63.19), uterine abnormalities (AOR = 13.57; 95%CI: 3.54–50.60), and antiphospholipid syndrome (AOR = 24.59; 95%CI: 8.45–71.04) were positively and independently associated with RPL. No significant risk factors were seen when the ASRM/ ESHRE criterion vs. WHO/RCOG criterion were compared. Advanced maternal age was significantly higher in secondary than in primary type of RPL.

Conclusion

The prevalence of RPL was 15.34% and 5.29% according to ASRM/ESHRE and WHO/RCOG criterion respectively, with secondary type predominating. No significant differences with regard to risk factors were seen according to diagnostic criteria studied, though advanced maternal age was significantly higher in secondary RPL. Further research is needed to confirm our findings and to better characterize the magnitude of differences.
Leveraging digital twin and game-engine for traffic simulations and visualizations
Authors: Rundel Samuel , De Amicis Raffaele
Published: February 2023

Combined with simulation software packages, City Information Models allow analysts and decision-makers to explore ‘what-if?’ questions and scenarios for various engineering and strategic applications. In this context, crowd and traffic simulations are most commonly utilized. Urban intelligent traffic management and pedestrian flow analysis greatly benefits from the latest generation of 3D City Information Models created from accurate urban-scale geospatial information. Analysis and simulation tools based on geometric, semantic, morphological, and structural information at the urban scale level offer the scientific foundation for all the activities required for identifying, detecting, planning, training, and analyzing vulnerability that may threaten human lives in urban environments. Nevertheless, the literature research showed that samples of operational Digital Twins incorporating simulation capabilities are impracticable for small municipalities and rural, low-income communities due to their complex infrastructure, hardware, and data requirements. It is desirable to reduce the requirements for these Digital Twins and still be capable of running comprehensive and accurate simulations based on urban-scale geospatial information. This article proposes an innovative framework and workflow capable of generating an operational Digital Twin and its visualization in the form of a 3D model using a procedural approach. The Digital Twin is connected with the traffic simulation SUMO and the Game Engine Unity for visualization using the TraCI middleware. The middleware is extended with additional functionalities and acts as an authoring tool. Unity allows visualizations in VR. The entire framework can be run on a single, standalone computer and is ready in a matter of minutes. The proposed framework for integrating modeling, simulation, and visualization of operational Digital Twins can help guide better decision-making for both rural areas as well as cities.
A glance into traditional pig slaughtering practices in Vietnam and opportunities for zoonotic disease prevention
Authors: Ting Nancy I. , Dang-Xuan Sinh , Gilbert Jeffrey , Nguyen Nguyen Thao Thi , Lam Steven , Nguyen-Viet Hung
Published: February 2023

Introduction

African swine fever in Vietnam is contributing to existing concerns over zoonotic disease transmission from sick pigs to humans. While slaughterhouses are key sites of occupational hazards to workers and contamination of meat, the specific slaughtering practices contributing to zoonotic occupational and foodborne disease risks remain under-researched. Our objective is to identify and characterize aspects of pig slaughtering processes that contribute to such risks.

Methods

We draw on qualitative observations, photos, and videos from three mobile slaughterhouses and seven abattoirs in Hung Yen, Vietnam.

Results

Based on our analysis, areas likely leading to zoonotic disease risks include slaughtering procedures, personal hygiene of workers, equipment sanitation, and facility sanitation. Within the small-scale swine industry, slaughtering practices are long-standing and difficult to change.

Conclusion

Our study underscores the importance of hygiene training of workers, improvements to equipment and facilities, and awareness-building activities targeting consumers to reduce the burden of zoonotic disease risks in small-scale pig slaughter settings.
Risk factors and new diagnostic index for deep venous thrombosis of lower extremities in elderly patients with traumatic femoral neck fracture
Authors: Chen Wenhao , Su Zhiming , Liu Quan , Bai Xinxin , Huang Jiyue , Weng Shaohuang , Chen Min
Published: February 2023

Purpose

To determine the incidence and risk factors of deep vein thrombosis (DVT) of lower extremities at admission in elderly Chinese patients with femoral neck fracture, and to establish and evaluate a new DVT predictor based on these risk factors.

Methods

Patients who were hospitalized from January 2018 to December 2020 at three independent centers were reviewed. According to the results of lower extremities vascular ultrasound at admission, they were divided into DVT group and non-DVT group. Single and multivariate logistic regression analysis were applied to identify independent risk factors for DVT occurrence, and then a prediction formula for DVT based on the risk factors was developed. The new predictive index of DVT was calculated by the formula. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic value of different factors and the new predictive index.

Results

There were 203 elder patients were included in the final analysis after application of the exclusion criteria. Thirty seven patients (18.2%) were diagnosed as DVT by ultrasound, including 33 patients (89.2%) of peripheral type, 1 patient (2.7%) of central type and 3 patients (8.1%) of mixed type.Multivariate logistic regression analysis showed that four factors including injured side, hemoglobin, fibrinogen, d-dimer were the independent risk factors for the incidence of DVT. On this basis, a new formula for DVT predictive factor was constructed: New predictive index = 0.895 * injured side (right = 1, left = 0) + 0.899 * hemoglobin (<109.5 g/L = 1, > 109.5 g/L = 0) + 1.19 * fibrinogen (>4.24 g/L = 1, < 4.24 g/L = 0) + 1.221* d-dimer (>2.4 mg/L = 1, < 2.4 mg/L = 0). The AUC value of this new developed index was 0.735.

Conclusions

This work showed that the incidence of DVT in elderly patients with femoral neck fracture in China was high at admission. New DVT predictive value can be used as an effective diagnosis strategy for evaluation of thrombosis at admission.
Inhibition of matrix metalloproteinases by HIV-1 integrase strand transfer inhibitors
Authors: Foster Emma G. , Palermo Nicholas Y. , Liu Yutong , Edagwa Benson , Gendelman Howard E. , Bade Aditya N.
Published: February 2023

More than fifteen million women with the human immunodeficiency virus type-1 (HIV-1) infection are of childbearing age world-wide. Due to improved and affordable access to antiretroviral therapy (ART), the number ofin uteroantiretroviral drug (ARV)-exposed children has exceeded a million and continues to grow. While most recommended ART taken during pregnancy suppresses mother to child viral transmission, the knowledge of drug safety linked to fetal neurodevelopment remains an area of active investigation. For example, few studies have suggested that ARV use can be associated with neural tube defects (NTDs) and most notably with the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG). After risk benefit assessments, the World Health Organization (WHO) made recommendations for DTG usage as a first and second-line preferred treatment for infected populations including pregnant women and those of childbearing age. Nonetheless, long-term safety concerns remain for fetal health. This has led to a number of recent studies underscoring the need for biomarkers to elucidate potential mechanisms underlying long-term neurodevelopmental adverse events. With this goal in mind, we now report the inhibition of matrix metalloproteinases (MMPs) activities by INSTIs as an ARV class effect. Balanced MMPs activities play a crucial role in fetal neurodevelopment. Inhibition of MMPs activities by INSTIs during neurodevelopment could be a potential mechanism for adverse events. Thus, comprehensive molecular docking testing of the INSTIs, DTG, bictegravir (BIC), and cabotegravir (CAB), against twenty-three human MMPs showed broad-spectrum inhibition. With a metal chelating chemical property, each of the INSTI were shown to bind Zn++ at the MMP’s catalytic domain leading to MMP inhibition but to variable binding energies. These results were validated in myeloid cell culture experiments demonstrating MMP-2 and 9 inhibitions by DTG, BIC and CAB and even at higher degree than doxycycline (DOX). Altogether, these data provide a potential mechanism for how INSTIs could affect fetal neurodevelopment.
Fabrication of 3D Bioprinted Bi-Phasic Scaffold for Bone–Cartilage Interface Regeneration
Authors: Chen Hongyi , Gonnella Giovanni , Huang Jie , Di-Silvio Lucy
Published: February 2023

Treatments for osteochondral defects (OCDs) are mainly palliative and, with the increase in this pathology seen among both young and elderly people, an alternative treatment modality is sought. Many tissue-engineered strategies have been explored for regenerating the cartilage–bone interface; however, they generally fall short of being ideal. Although cell-laden hydrogel scaffolds are a common approach for bone and cartilage tissue regeneration, they usually lack homogenous cell dispersion and patient specificity. In this study, a biphasic 3D bioprinted composite scaffold was fabricated for cartilage–bone interface regeneration. To overcome the shortcoming of both materials, alginate–gelatin (A–G) hydrogel was used to confer a naturally occurring environment for the cells and polycaprolactone (PCL) was used to enhance mechanical stability, thus maximizing the overall performance. Hydroxyapatite fillers were added to the PCL in the bone phase of the scaffold to improve its bioactivity. Physical and biological evaluation of scaffolds in both phases was assessed. The scaffolds demonstrated a desirable biological response both singly and in the combined PCL/A-G scaffolds, in both the short term and longer term, showing promise as an interfacial material between cartilage and bone.
The Effect of the Treatment of Severe Early Childhood Caries on Growth-Development and Quality of Life
Authors: Bagis Ecenur Eyisoy , Derelioglu Sera Simsek , Sengül Fatih , Yılmaz Sinan
Published: February 2023

Purpose: Untreated early childhood caries (ECC) adversely affect children’s quality of life. Our aim was to evaluate the effects of ECC on growth, development, and quality of life. Design and Methods: A total of 95 children were divided into three groups: general anesthesia (GA) (n = 31), dental clinic (DC) (n = 31), and control (n = 33). ECOHIS was applied to the parents in the GA and DC groups during a pre-treatment period and also applied in the post-treatment in the first and sixth months. Height, weight, and BMI measurements of the children in the study groups were taken and recorded at the pre-treatment stage and in the post-treatment in the first and sixth months. However, for the control group, these measurements were made just at the baseline and in the sixth month. Results: Upon the treatment of ECC, the total ECOHIS score significantly decreased (p < 0.001) in both groups in the following first month, whereas the scores of the children in the GA group reached a similar level to the DC group at the end of the sixth month. Following treatment, the weight and height of the children with ECC who initially had significantly lower BMI percentiles than the control group (p = 0.008) were observed to increase and, thus, they reached a similar BMI percentile value to the control group in the sixth month. Conclusions: The results of our study revealed that development and growth deficiencies in the children with ECC could be reversed rapidly by dental treatments and, thus, their quality of life would increase. The importance of treating ECC was revealed since treating ECC had positive effects both on the children’s growth and development and on the quality of life of the children and their parents.
UAV Path Planning in Multi-Task Environments with Risks through Natural Language Understanding
Authors: Wang Chang , Zhong Zhiwei , Xiang Xiaojia , Zhu Yi , Wu Lizhen , Yin Dong , Li Jie
Published: February 2023

Path planning using handcrafted waypoints is inefficient for a multi-task UAV operating in dynamic environments with potential risks such as bad weather, obstacles, or forbidden zones, among others. In this paper, we propose an automatic path planning method through natural language that instructs the UAV with compound commands about the tasks and the corresponding regions in a given map. First, we analyze the characteristics of the tasks and we model each task with a parameterized zone. Then, we use deep neural networks to segment the natural language commands into a sequence of labeled words, from which the semantics are extracted to select the waypoints and trajectory patterns accordingly. Finally, paths between the waypoints are generated using rapidly exploring random trees (RRT) or Dubins curves based on the task requirements. We demonstrate the effectiveness of the proposed method using a simulated quadrotor UAV that follows sequential commands in four typical tasks with potential risks.
Generalized Toffoli Gate Decomposition Using Ququints: Towards Realizing Grover’s Algorithm with Qudits
Authors: Nikolaeva Anstasiia S. , Kiktenko Evgeniy O. , Fedorov Aleksey K.
Published: February 2023

Qubits, which are the quantum counterparts of classical bits, are used as basic information units for quantum information processing, whereas underlying physical information carriers, e.g., (artificial) atoms or ions, admit encoding of more complex multilevel states—qudits. Recently, significant attention has been paid to the idea of using qudit encoding as a way for further scaling quantum processors. In this work, we present an efficient decomposition of the generalized Toffoli gate on five-level quantum systems—so-called ququints—that use ququints’ space as the space of two qubits with a joint ancillary state. The basic two-qubit operation we use is a version of the controlled-phase gate. The proposed N-qubit Toffoli gate decomposition has O(N) asymptotic depth and does not use ancillary qubits. We then apply our results for Grover’s algorithm, where we indicate on the sizable advantage of using the qudit-based approach with the proposed decomposition in comparison to the standard qubit case. We expect that our results are applicable for quantum processors based on various physical platforms, such as trapped ions, neutral atoms, protonic systems, superconducting circuits, and others.
Acknowledgment to the Reviewers of Electrochem in 2022
Authors:   Electrochem Editorial Office
Published: February 2023

High-quality academic publishing is built on rigorous peer review [...]
The Collaborative Optimization of the Discharge Pressure and Heat Recovery Rate in a Transcritical CO2 Heat Pump Used in Extremely Low Temperature Environment
Authors: Wu Zhongkai , Bi Feifei , Fei Jiyou , Zheng Zecan , Song Yulong , Cao Feng
Published: February 2023

Considering the excellent environmental properties and heating capability under wide running conditions of the natural fluid CO2, the transcritical CO2 heat pump system has widely been used in the application of water heaters, commercial heating and cooling, electric vehicle thermal management, etc. Since the performance was highly affected by the discharge pressure and heat recovery rate in a transcritical CO2 system, the collaborative optimization of these two parameters was analyzed in detail in this study. The results showed that the optimal value of the system heating COP, which was the ration of heating capacity to power consumption, was better under a higher heat recovery rate and relatively lower discharge pressure, which is why these kinds of operating conditions are highly recommended from the perspective of collaborative optimization. Additionally, the heat recovery rate had a positive effect on the system performance when the discharge pressure was lower than its optimal value, while the heat recovery rate would present a passive effect on the system performance when the discharge pressure was higher than its optimal value. The relevant conclusions of this study provide a good theoretical basis for the efficient and stable operation of the transcritical CO2 heat pump technology under the conditions of a wide ambient temperature range.
Application of Biogas and Biomethane as Maritime Fuels: A Review of Research, Technology Development, Innovation Proposals, and Market Potentials
Authors: Mallouppas George , Yfantis Elias Ar. , Ioannou Constantina , Paradeisiotis Andreas , Ktoris Angelos
Published: February 2023

This review paper examines the applicability of biogas and biomethane as potential maritime fuels and examines issues of these fuels from a supply chain perspective (from production to end use). The objectives are to identify: (1) the latest research, development, and innovation activities; (2) issues and key barriers related to the technology readiness to bring biogas/biomethane to market; and (3) commercialisation issues, including cost parity with natural gas (the main competitor). A survey of the literature was carried out based on research articles and grey literature. The PESTEL and SWOT analyses identified opportunities for these fuels due to the relevant regulations (e.g., Fit for 55; the recent inclusion of the Mediterranean Sea as a SECA and PM control area; MPEC 79), market-based measures, and environmental, social, and governance strategies. The potential of biomass feedstock is estimated to have a substantial value that can satisfy the energy needs of the maritime industry. However, production costs of biomethane are high; estimated to be 2–4 times higher compared to natural gas. The market is moving in the direction of alternative drop-in fuels, including liquefied and compressed biomethane (LBM and CBM) and biogas. In terms of potential market penetration, LBM can be used as a marine drop-in fuel for the existing fleet that already combust LNG and LPG due to similar handling. Currently, these vessels are LNG and LPG tankers. However, in newly built vessels, LBM can be also supplied to container ships, vehicle carriers, and bulk carriers (about 20% of newly built vessels). Provided that compressed natural gas infrastructure exists, CBM can be exploited in vessels with low energy needs and low space requirements and shore-side electrification, because investments in retrofits are lower compared to constructing new infrastructure.
Customised Multi-Energy Pricing: Model and Solutions
Authors: Hong Qiuyi , Meng Fanlin , Liu Jian
Published: February 2023

With the increasing interdependence among energies (e.g., electricity, natural gas and heat) and the development of a decentralised energy system, a novel retail pricing scheme in the multi-energy market is demanded. Therefore, the problem of designing a customised multi-energy pricing scheme for energy retailers is investigated in this paper. In particular, the proposed pricing scheme is formulated as a bilevel optimisation problem. At the upper level, the energy retailer (leader) aims to maximise its profit. Microgrids (followers) equipped with energy converters, storage, renewable energy sources (RES) and demand response (DR) programs are located at the lower level and minimise their operational costs. Three hybrid algorithms combining metaheuristic algorithms (i.e., particle swarm optimisation (PSO), genetic algorithm (GA) and simulated annealing (SA)) with the mixed-integer linear program (MILP) are developed to solve the proposed bilevel problem. Numerical results verify the feasibility and effectiveness of the proposed model and solution algorithms. We find that GA outperforms other solution algorithms to obtain a higher retailer’s profit through comparison. In addition, the proposed customised pricing scheme could benefit the retailer’s profitability and net profit margin compared to the widely adopted uniform pricing scheme due to the reduction in the overall energy purchasing costs in the wholesale markets. Lastly, the negative correlations between the rated capacity and power of the energy storage and both retailer’s profit and the microgrid’s operational cost are illustrated.
Editor’s Choice: Advances in Carbon Capture Subsurface Storage and Utilization
Authors: Andersen Pål Østebø
Published: February 2023

This “Editor’s Choice” article summarizes nine recent articles in Energies focusing on carbon capture, subsurface storage, and utilization [...]
The “True Colours” of Golden Loaches (Teleostei: Cobitidae)
Authors: Fedorčák Jakub , Šanda Radek , Stefanov Tihomir , Mendel Jan , Nowak Michal , Križek Peter , Perdices Anabel , Vukić Jasna , Koščo Ján
Published: February 2023

Loaches of the genus Sabanejewia are model organisms for many ichthyologic studies focusing on morphological and colour variation. The bright lateral spots—a part of the mimicry of this fish—cause a taxonomic puzzle. Common practice is that morphometric and molecular studies lack habitat assessments of species originating from different environments. In this study, we analysed body shape and colour variation within two species of Sabanejewia in order to reveal whether they are more affected by phylogeny or environmental conditions. The environmental parameters were obtained using satellite mapping tools, body shape using geometric morphometry, and the molecular identification of specimens using an analysis of mitochondrial DNA (sequence of the cytochrome b gene). Generalized linear mixed models were used for the analysis of lateral spot numbers, and principal components analysis to describe the changes in landmark position defined by the permutation tests. Results show a significant impact of the locality elevation and specimen’s sex on the change of the body shape. We identified significant differences in the number of lateral spots, which are considered mimicry variation across an elevation gradient. Morphological differences of Sabanejewia spp. vary with ecological factors along the river continuum.
Impact of Aging Microbiome on Metabolic Profile of Natural Aging Huangjiu through Machine Learning
Authors: Yu Huakun , Liu Shuangping , Zhou Zhilei , Zhao Hongyuan , Xu Yuezheng , Mao Jian
Published: February 2023

Aging is a time-consuming step in the manufacturing of fermented alcoholic beverages. Natural-aging huangjiu sealed in pottery jars was taken as an example to investigate the changes of physiochemical indexes during aging and to quantify intercorrelations between aging-related factors and metabolites through machine learning methods. Machine learning models provided significant predictions for 86% of metabolites. Physiochemical indexes well reflected the metabolic profile, and total acid was the most important index that needed to be controlled. For aging-related factors, several aging biomarkers of huangjiu were also well predicted. Feature attribution analysis showed aging year was the most powerful predictive factor, and several microbial species were significantly associated with aging biomarkers. Some of the correlations, mostly connected to environmental microorganisms, were newly found, showing considerable microbial influence on aging. Overall, our results reveal the potential determinants that affect the metabolic profile of aged huangjiu, paving the way for a systematical understanding of changes in metabolites of fermented alcoholic beverages.
Impact of Cervical Cancer on Quality of Life and Sexuality in Female Survivors
Authors: Membrilla-Beltran Lucia , Cardona Diana , Camara-Roca Laura , Aparicio-Mota Adrian , Roman Pablo , Rueda-Ruzafa Lola
Published: February 2023

Cervical cancer is the fourth most frequent cancer in women worldwide, and the 11th most frequent neoplasm in Spain. Despite the optimization of treatments and a 5-year survival rate of 70%, side effects and sequelae are described after treatment. The treatments have physical, psychological and sociocultural consequences that deteriorate the quality of life of patients. One of the sequelae that worries patients is the impairment of sexual function and satisfaction, considered a fundamental dimension of the human being. The aim of this study was to examine quality of life and sexual function and satisfaction among Spanish cervical cancer survivors. A retrospective case-control study was conducted between 2019 and 2022. The sample consisted of 66 patients who completed the Female Sexual Function Index, the Golombok Rust Sexual Satisfaction Inventory and European Organization for Research and Treatment of Cancer quality of life questionnaire. The control group consisted of women without cervical cancer and gynecological pathologies obtained using the so-called online virtual sampling method. The patient group consisted of women with cervical cancer who completed treatment. Cervical cancer survivors reported sexual dysfunction and impaired sexual satisfaction in almost half of the domains. Quality of life was also affected, with pain and fatigue being the most frequent symptoms in these patients. Our results indicate that there is dysfunction, sexual dissatisfaction and a lower level of quality of life in cervical cancer survivors than in healthy women without pathology.
Evidence of Use of Whole-Body Vibration in Individuals with Metabolic Syndrome: A Systematic Review and Meta-Analysis
Authors: Coelho-Oliveira Ana Carolina , Monteiro-Oliveira Bruno Bessa , Gonçalves de Oliveira Raphael , Reis-Silva Aline , Ferreira-Souza Luiz Felipe , Lacerda Ana Cristina Rodrigues , Mendonça Vanessa A. , Sartorio Alessandro , Taiar Redha , Bernardo-Filho Mario , Sá-Caputo Danúbia
Published: February 2023

(1) Background: Metabolic syndrome (MSy) is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increase the risk of cardiovascular disease. This systematic review with meta-analysis was conducted to assess the effects of whole-body vibration exercise (WBVE) in metabolic syndrome (MSy) individuals. (2) Methods: An electronic search in Pubmed, Embase, Scopus, Web of Science, ScienceDirect, PEDro, and CINAHL databases in December 2022 was performed. Data regarding the included studies were extracted. The level of evidence, the methodological quality, and the risk of bias of each selected publication were individually evaluated. (3) Results: Eight studies were included in the systematic review and four studies in the meta-analysis, with a mean methodological quality score on the Physiotherapy Evidence Database (PEDro scale) of 5.6, considered “fair” quality. The qualitative results suggested positive effects of the systemic vibration therapy in relevant outcomes, such as quality of life, functionality, pain level, trunk flexibility, cardiovascular responses (blood pressure and heart rate), neuromuscular activation, range of motion of the knees, rating of perceived exertion, and body composition. The quantitative results, with weighted mean differences, standard mean differences, and 95% confidence intervals (CIs), were calculated. Conclusions: WBVE may be an alternative capable of interfering with physical—mainly for flexibility with weighted mean differences (1.70; 95% CI 0.15, 3.25; n = 39)—functional, psychosocial, neuromuscular, emotional parameters, and consequently contribute to improvements in metabolic health and reduce the cardiovascular risk factor in MSy individuals. Nevertheless, further additional studies are required to understand the long-term effects of WBVE on MSy and its complications in a better way. Protocol study registration was as follows: PROSPERO (CRD 42020187319).
Patient Care in Community Pharmacies during the COVID-19 (SARS-CoV-2) Pandemic: Effectiveness of Post-Graduate Education and Further Training Courses on Revenues
Authors: Baratta Francesca , Folpini Elena , Ciccolella Michele , Brusa Paola
Published: February 2023

Thanks to their distribution throughout the territory and extended opening hours, community pharmacists are among the healthcare specialists most easily accessible to the public and often represent the first point of consultation both for the treatment of acute health conditions and, more generally, for health and therapy advice. The objective of the present study was to evaluate whether post-graduate courses/further training courses for pharmacists might influence the quality of patient management and care and, consequently, the satisfaction of the users who entered the pharmacy. We used the revenues of the pharmacies (Group A) in which these pharmacists are employed as a performance indicator. We compared the data for this group with the national averages for Italian pharmacies (Group B) and with those of a group (Group C) of selected pharmacies as similar as possible to the pharmacies in Group A based on a number of well-defined parameters. The comparison of revenues, year-on-year changes, and the average number of sales by the pharmacies in the three groups indicates that the pharmacies in Group A had the best performance, not only when compared with the national average but especially compared with the control group, specifically selected to make the comparison as significant as possible.
The Presence of a Single Nuchal Cord in the Third Trimester May Not Affect Tei Index in LGA Fetuses
Authors: Murlewska Julia , Poszwa Przemysław , Sylwestrzak Oskar , Respondek-Liberska Maria , Wood Dennis
Published: February 2023

(1) Background: The aim of this study was to assess the RV (right ventricle) and LV (left ventricle) Tei index in large for gestational age (LGA) fetuses with a single 360-degree umbilical coil of the umbilical cord around the fetal neck identified by ultrasound in the third trimester of gestation. (2) Methods: The RV and LV Tei index for the cardiac function were measured in 297 singleton pregnancies, and we identified 25 LGA fetuses. There were 48% of LGA fetuses with a nuchal umbilical cord—LGA/NC—larger for gestational age fetuses with a nuchal cord. NC was detected with a color Doppler during a transverse scan of the fetal neck, when the umbilical cord formed a U shape. All fetuses had normal anatomy and normal uterine, placental, umbilical, intracardiac and cerebral Doppler waveforms values for their gestational age. (3) Results: The RV Tei index was significantly higher in the LGA subgroup vs. AGA (0.6 ± 0.2 vs. 0.50 ± 0.2; p value = 0.01), but in LGA fetuses with a single coil of the nuchal cord, there were not any significant changes in the Tei indexes. (4) Conclusions: The Tei index might not be impacted by the presence of the nuchal cord in LGA fetuses.
Is Preoperative Asymmetry a Predictor of Postoperative Asymmetry in Patients Undergoing Breast Reduction?
Authors: Zawadzki Tomasz , Antoszewski Bogusław , Kasielska-Trojan Anna
Published: February 2023

Plastic surgeons aim to achieve symmetry in breast surgeries, which is the main determinant of chest aesthetics. The aim of this study was to verify if preoperative breast asymmetry is a predictor of postoperative asymmetry in women undergoing breast reduction. In this prospective study, we enrolled 71 women (the mean age 37 years, SD 10 years) with breast hypertrophy who underwent reduction mammaplasty. We collected clinical data including age, height, weight, weight of the resected tissues, and performed pre and postoperative photographic documentation. The following measurements of both breasts were analyzed: volumes (vol), nipple–sternal notch distance (A-sn), difference between nipples’ levels (A-A’), nipple–midline distance (A-ml), difference between inframammary folds levels (IF-IF’), distance between inframammary fold and nipple (IF-A), distance between inframammary fold apex and midline (IF-ml). All measurements were performed preoperatively and 6 months after the surgery and asymmetries of all variables were calculated (asy-vol, A-A’, asyA-sn, asyA-ml, IF-IF’, asyIF-A, asyIF-ml). Postoperative asymmetry of breast volumes and nipples position was not associated with any of the analyzed clinical variables. Postoperative asymmetry of nipples’ level was associated with preoperative asymmetry of IF-ml; however, logistic regression did not detect any preoperative measurement influencing postoperative volume and nipples’ level asymmetry. Moreover, we found that preoperative asyIF-ml increased the risk of postoperative volume asymmetry, which is above the average (52 cc) (OR = 2.04). Postoperative breast asymmetry after breast reduction is not related neither to preoperative asymmetries nor clinical variables; however, asymmetry of inframammary fold apex to the midline may be the factor affecting postoperative volumetric asymmetry.
Insomnia among Cancer Patients in the Real World: Optimising Treatments and Tailored Therapies
Authors: Pinucci Irene , Maraone Annalisa , Tarsitani Lorenzo , Pasquini Massimo
Published: February 2023

Background: Insomnia is commonly reported by cancer patients. Its multifaceted pathophysiology makes this symptom a complex challenge for the clinician, who should bear in mind the manifold world of causes and consequences of sleep disturbances in these patients and the importance of accurate treatment that should consider the frequent co-prescription of multiple medications. With our work, we aim to provide a tool to better master the treatment of this symptom in cancer patients, considering the gap between clinical and pharmacodynamic knowledge about the efficacy of different molecules and evidence-based prescribing. Methods: A narrative review of the studies investigating the pharmacological treatment of insomnia in cancer patients was conducted. Three hundred and seventy-six randomised controlled trials (RCTs), systematic reviews and meta-analyses were identified through PubMed. Only publications that investigated the efficacy of the pharmacological treatment of insomnia symptoms in cancer patient were considered. Results: Among the 376 publications that were individuated, fifteen studies were eligible for inclusion in the review and were described. Pharmacological treatments were outlined, with a broad look at specific clinical situations. Conclusions: The management of insomnia in cancer patients should be personalised, as is already the case for the treatment of pain, taking into account both the pathophysiology and the other medical treatments prescribed to these patients.