bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Debt To Equity Ratio, Total Assets Turnover, Dan Volume Penjualan Terhadap Profitabilitas Pada Perusahaan Property Dan Real Estate Yang Terdaftar Dalam Bursa Efek Indonesia
Authors: Desy Desy Anwar
Published: April 2022

The main objective of this study is to examine the effect of debt to equity ratio, total asset turnover, and sales volume on profitability in property and real estate companies listed on the Indonesia Stock Exchange in 2013-2017. debt to equity ratio is the ratio chosen from the solvency ratio that can reflect a company's ability to meet all its financial obligations both long-term and short-term. Asset turnover is the ratio chosen from the activity ratio aimed at measuring the level of effectiveness of the company in using operating assets. Sales volume is based on the total sales the company gets. Profitability aims to measure how much the company's ability to generate profits. The population of property and real estate companies consists of 48 companies and the number of research samples consists of 27 property and real companies in 2013-2017 determined through the purposive sampling method using certain criteria. The method used in this research is quantitative, the type of research used is descriptive, the nature of this study is causal and the type of data is secondary obtained through the Indonesian stock exchange. This research was conducted with multiple regression analysis and classical assumption test. The classic assumption test consists of a normality test, a multicollinearity test, an autocorrelation test and a heteroscedasticity test. The results of this study indicate that the debt to equity ratio has a negative and significant effect on profitability, total assets turnover has a positive and significant effect on profitability and sales volume has a positive and not significant effect on profitability. debt to equity ratio, total asset turnover and sales volume simultaneously influence the profitability of porperty and real estate companies listed on the Indonesia Stock Exchange for the period 2013 - 2017.
Pengaruh profitability, liquidity, growth asset, firm value, dan structure value equity terhadap dividen policy pada perusahaan property & real estate yang terdaftar di bursa efek indonesia periode 2012-2016
Authors: Michael Michael tanoto
Published: April 2022

The objective of the study is to test and analyze the effects of liquidity, leverage, company growth, firm value, and profitability on dividend policies in the Property & Real Estate companies on the Indonesia Stock Exchange in the period of 2012-2016. The research was based on information obtained from the Indonesia Stock Exchange. The research used a purposive sampling technique. The research populations were Property & Real Estate companies listed on the Indonesia Stock Exchange in 2012-2016 with the total samples of 15 companies. The research data were analyzed by using multiple linear regression analysis. The result shows that profitability (ROA) has a significant effect on dividend policy on Property & Real Estate companies on the Indonesia Stock Exchange and simultaneously, Liquidity (CR), Leverage (DER), Growth Asset (TA) and firm value do not have any significant effect on dividend policy on Property & Real Estate companies in the Indonesia Stock Exchange
PENGARUH CURRENT RATIO, PENDAPATAN, DAN B IAYA OPERASIONAL TERHADAP PROFITABILITAS PADA PT. PERKEBUNAN NUSANTARA III MEDAN
Authors: Yeyen Yeyen Syarival Banjarnahor
Published: April 2022

Perkebunan Nusantara III Medan merupakan perusahaan yang bergerak dibidang pengelolaan, pengolahan, dan pemasaran hasil perkebunan yang beralamat di jalan Sei Batang Hari No.2 Medan Sunggal. Penelitian ini bertujuan untuk menguji dan menganalisis bagaimana pengaruh current ratio, pendapatan, dan biaya operasional terhadap profitabilitas di PT. Perkebunan Nusantara III Medan periode 2011- 2014. Metode penelitian yang digunakan dalam penelitian ini menggunakan metode pendekatan kuantitatif, jenis penelitian adalah deskriptif kuantitatif yang bersifat hubungan kausal. Populasi dan sampel penelitian ini sebanyak 4 tahun atau 48 bulan (data) laporan current ratio, pendapatan dan biaya operasional yaitu dari tahun 2011-2014,dengan teknik pengambilan data sampling jenuh. Metode analisis data dalam penelitian ini adalah analisis regresi linier berganda dengan uji asumsi klasik. Hasil penelitian ini menunjukkan secara simultan current ratio, pendapatan, dan biaya operasional berpengaruh signifikan terhadap profitabilitas, dengan hasil Fhitung = 89,089 > Ftabel = 2,82. Secara parsial pendapatan dan biaya operasional berpengaruh dan tidak signifikan sedangkan current ratio tidak berpengaruh dan tidak signifikan terhadap laba bersih pada PT. Perkebunan Nusantara III Medan periode 2011-2014.
Young People and Leadership: Questions of Access in Secondary Schools
Authors: Emerson Sue , Ferkins Lesley , Bryham Gaye , Sieuw Mieke
Published: April 2022

There is seemingly an abundance of leadership opportunities available to youth within school environments, including sport captaincy, sport coaching, prefect roles, and assigned arts or cultural leadership. For many students, the opportunity to captain a sports team, or lead an event or activity is perceived as their first taste of leadership action. However, as evidenced in a growing body of literature (Jackson & Parry, 2011), leadership is increasingly being conceived as much more than an assigned formal position. Furthermore, there is some evidence to suggest that formal leadership roles may be presenting barriers for students wishing to access leadership opportunities in a more informal capacity (McNae, 2011). In this conceptual article, we examine the value and nature of informal leadership practices, and from this, identify questions of access to leadership for youth in secondary school settings. Specifically, the aim of our paper is to advance current conceptualisations about youth leadership and to offer future research directions (via questions) to establish a deeper evidence base for better understanding access to leadership for youth. To achieve this, we explore three interrelated themes: leadership practices and accessibility for youth; learning through leadership for youth; youth access and the notion that leadership belongs to everybody. As a result of the platform provided by our conceptualising, a series of questions are presented for future research. Directions for future research relate to understanding more about formal and informal leadership opportunities in the secondary school context, what we will hear when we listen to the student’s voice about access to these opportunities, and how informal leadership opportunities might influence overall access to leadership for students.
A Method of Sound Wave Diffusion in Motor Vehicle Exhaust Systems
Authors: Singh Niranjan
Published: April 2022

It is common practice among young vehicle owners to modify the exhaust system of their vehicle to reduce exhaust backpressure with the perception that the output power increases. In the process of backpressure reduction, the output noise (Whakapau) of the vehicle also increases correspondingly. The conflict of interest that arises from modified vehicle exhaust systems and the general public is well publicised. This prototype was designed to meet the demands of exhaust back pressure reduction while at the same time mitigate the sound output of the vehicle. The design involves lining a cylindrical pipe with common glass marbles which is normally used for playing. The marbles are made of a sustainable material as it does not erode when exposed to exhaust gases and it is easily recycled. The prototype muffler is much smaller in size when compared to conventional mufflers. All tests were done in a simulated controlled environment and data collated using approved New Zealand Transport Agency testing regime. It has to be noted that the test focus was noise mitigation and not comprehensive engine performance testing. The results of the test prove a reduction of sound levels, however more testing needs to be undertaken with varying annulus depth, marble sizes and arrangements and engine loads.
Asynchronous Instructional Videos During COVID-19 Emergency Remote Teaching: Student Experiences Within a New Zealand ITP
Authors: Dassanayake Wajira , Hewagama Gayani , Kirk Sarah E
Published: April 2022

The COVID-19 pandemic created unprecedented challenges for tertiary education institutions worldwide. The crisis placed enormous pressure on educational institutions as they were required to pivot suddenly to teaching fully online. In New Zealand, Tertiary Education Organisations (TEOs) were forced to close on Wednesday 25 March 2020 after New Zealand moved to Alert Level 4, necessitating the sudden implementation of online teaching. The purpose of this study is to investigate the effectiveness of pre-recorded instructional videos in three selected courses taught by a tertiary education institution, a member of the Institutes of Technology and Polytechnics (ITPs) New Zealand.
Entry-level tertiary student perceptions of challenges when using a wiki: Trust and peer teaching
Authors: Hammond Kay , Powell Catherine
Published: April 2022

Wikis are widely used in blended learning educational settings with varying degrees of success. Scholarly attention increasingly regards student perceptions and experiences of using wikis as part of ongoing development. Students in entry-level education often belong to high-needs target groups who particularly require positive experiences for a successful transition into tertiary education. This paper reports action research exploring the use of a wiki by certificate-level students at a tertiary institution. The results showed most students did not engage with the wiki. Qualitative student feedback revealed valuable insight into two major social challenges when interacting online: trust and difficulties with peer-teaching. Recommendations are made regarding these social challenges that should be considered by educators aiming to use a wiki or other collaborative online learning and teaching spaces for entry-level education.
Preparing Vocational Students for Future Workplaces: Towards a course evaluation of the Unitec Bachelor of Applied Engineering
Authors: Marsden Nick , Singh Niranjan
Published: April 2022

This exploratory study set out to evaluate how well a particular course in automotive engineering is set up to enable students to develop skills necessary to enter the workplace. The research set out to identify trends in student expectations and in the needs of employers at a time when this field of work is characterised by disruptive technological developments such as computerisation and automation. The intended outcome of the research is that the findings will assist the critical thinking of course designers as they reflect on modifications that might be necessary for Unitec Bachelor of Applied Technology (BAT) graduate attributes to fully meet future workplace demands. It is also an aim that this exploratory evaluation of a small cohort of students can, despite its limitations, identify trends for future pedagogical research in the ITP (Institutes of Technology and Polytechnics) sector. Although not a full course evaluation, this study invited feedback from students and recent graduates in relevant employment regarding the alignment of the Unitec Bachelor of Applied Technology (BAT) course design with their perceptions of skills necessary in the workplace. Another intention was to highlight any misalignments between the realities of the automotive engineering sector and student expectations of the course: To what degree are work capability expectations in agreement between the student stakeholders and the institution? Are the course goals realistic and in line with actual industry needs? How is the definition of work readiness changing? The paper also samples current speculative thinking about skills that are becoming progressively more important in the workplace, namely the so-called ‘soft skills’ in communication, problem solving, management and collaboration, and in dialogic and creative attributes relevant to increasingly automated and globalised workplaces.
Delirium Assessment and Management: A qualitative study on aged-care nurses’ experiences
Authors: Jauny Ray , Parsons John
Published: April 2022

Aged residential care (ARC) residents with morbid health conditions frequently experience delirium. This condition is associated with diminished quality of life, preventable morbidity and untimely death. It is challenging and costly to manage delirium because of the complex interplay of physical and psychiatric symptoms associated with this condition in both primary and secondary services. With awareness of risk factors and knowledge about delirium, ARC nurses can play a vital role in early identification, assessment and treatment, but most importantly in preventing delirium in aged-care residents as well as improving health outcomes. Focus groups were carried out with ARC nurses to ascertain their opinions on how they assess and manage delirium in ARC facilities in South Auckland, New Zealand. Findings identified that there were strengths and weaknesses, as well as gaps in assessment and management of delirium. Nurses would benefit from delirium education, appropriate tools and adequate resources to help them manage delirium. Issues with diagnosing delirium, anxiety about challenging behaviours, family dynamics, lack of training and absence of IV treatment were noticeable features in this study.
Leadership Through Peer Mediation
Authors: Connor Helene , Buccahan Leo
Published: April 2022

This report presents the findings of preliminary research into the perceptions of overall stakeholder satisfaction of eight Auckland secondary schools of the Leadership through Peer Mediation (LtPM) programme, a core programme of the Foundation for Peace Studies Aotearoa New Zealand (the Peace Foundation). The research was commissioned by the Peace Foundation with funding assistance from the Metro ITP Voucher Scheme, and was conducted in the second half of 2015. A core aim of the LtPM programme is to empower students as ‘ambassadors of social justice’. The programme trains students in the mediation processes and leadership skills needed to assist peers to resolve personal conflicts in a peaceful manner.
Investigation of the Effects of Apigenin, a Possible Therapeutic Agent, on Cytotoxic and SWH Pathway in Colorectal Cancer (HT29) Cells
Authors: Cicek Mustafa , Unsal Velid , Emre Arif , Doganer Adem
Published: April 2022

Purpose: Colorectal cancer (CRC) is one of the most common and fatal malignancies in humans, still leading to serious morbidity and mortality.We here aimed to investigate the effects of flavonoid apigenin, which is considered to have anti-tumoral activity on colorectal cancer with high epidemiological prevalence, on cell proliferation and cell survivals, and the positive and negative dose-dependent effects of genetic or mutational alterations in SWH pathway components on HT29 colorectal cancer cell lines. Methods: Human colon cancer cell lines HT-29 were commercially available. In each flask, 5 groups were formed, each of which consists of 5,000 cells for different dose groups and the cells were plated. After a 24 and 48 h incubation period, cytotoxicity values were measured by MTT assay and gene expression was assessed by Real-Time PCR analysis method. Results: Application of 12.5 and 25 nM of apigenin significantly increased cell death in HT29 cell lines. LATS1, STK3 and TP53 gene expression decreased in the same dose groups compared to control and other groups. Conclusion: It has been concluded that TP53 gene is strongly correlated with LATS1 and STK3 genes among the SWH pathway factors in the progression of colorectal cancer and could be used as an important marker for early detection of malignant transmission. In addition, it may be effective in colorectal cancer cases especially when 25 nM of apigenin applies for therapeutic purpose.
Stem Cell’s Secretome Delivery Systems
Authors: Umar Abd. Kakhar
Published: April 2022

Stem cells’ secretome contains biomolecules that are ready to give therapeutic activities. However, the biomolecules should not be administered directly because of their in vivo instability. They can be degraded by enzymes or seep into other tissues. There have been some advancements in localized and stabilized secretome delivery systems, which have increased their effectiveness. Fibrous, in situ, or viscoelastic hydrogel, sponge-scaffold, bead powder/ suspension, and bio-mimetic coating can maintain secretome retention in the target tissue and prolong the therapy by sustained release. Porosity, young’s modulus, surface charge, interfacial interaction, particle size, adhesiveness, water absorption ability, in situ gel/film, and viscoelasticity of the preparation significantly affect the quality, quantity, and efficacy of the secretome. Therefore, the dosage forms, base materials, and characteristics of each system need to be examined to develop a more optimal secretome delivery system. This article discusses the clinical obstacles and potential solutions for secretome delivery, characterization of delivery systems, and devices used or potentially used in secretome delivery for therapeutic applications. This article concludes that secretome delivery for various organ therapies necessitates the use of different delivery systems and bases. Coating, muco-, and cell-adhesive systems are required for systemic delivery and to prevent metabolism. The lyophilized form is required for inhalational delivery, and the lipophilic system can deliver secretomes across the blood-brain barrier. Nano-sized encapsulation and surface-modified systems can deliver secretome to the liver and kidney. These dosage forms can be administered using devices such as a sprayer, eye drop, inhaler, syringe, and implant to improve their efficacy through dosing, direct delivery to target tissues, preserving stability and sterility, and reducing the immune response.
Polymersomes Based Versatile Nanoplatforms for Controlled Drug Delivery and Imaging
Authors: Kotha Rohini , Kara Divya Dhatri , Roychowdhury Rajeshwari , Tanvi Katikala , Rathnanand Mahalaxmi
Published: April 2022

Drug delivery systems made based on nanotechnology represent a novel drug carrier system that can change the face of therapeutics and diagnosis. Among all the available nanoforms polymersomes have wider applications due to their unique characteristic features like drug loading carriers for both hydrophilic and hydrophobic drugs, excellent biocompatibility, biodegradability, longer shelf life in the bloodstream and ease of surface modification by ligands. Polymersomes are defined as the artificial vesicles which are enclosed in a central aqueous cavity which are composed of self-assembly with a block of amphiphilic copolymer. Various techniques like film rehydration, direct hydration, nanoprecipitation, double emulsion technique and microfluidic technique are mostly used in formulating polymersomes employing different polymers like PEO-b-PLA, poly (fumaric/sebacic acid), poly(N-isopropylacrylamide) (PNIPAM), poly (dimethylsiloxane) (PDMS), and poly(butadiene) (PBD), PTMC-b-PGA (poly (dimethyl aminoethyl methacrylate)-b-poly(l-glutamic acid)) etc. Polymersomes have been extensively considered for the conveyance of therapeutic agents for diagnosis, targeting, treatment of cancer, diabetes etc. This review focuses on a comprehensive description of polymersomes with suitable case studies under the following headings: chemical structure, polymers used in the formulation, formulation methods, characterization methods and their application in the therapeutic, and medicinal filed.
The Efficacy and Safety of Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis: A Pilot Study
Authors: Shamsaei Gholamreza , Houshmand Fatemeh , Ahmadzadeh Deylami Ahmad , Valizadeh Armita , Rafie Shahram , Moradi Maryam
Published: April 2022

Purpose: Amyotrophic lateral sclerosis (ALS) is an uncommon and aggressive neurodegenerative disorder that influences the lower and upper motor neurons. There are low eligible drugs for ALS treatment; in this regard, supplemental and replacement treatments are essential. There are relative studies in the field of mesenchymal stromal cells (MSCs) therapy in ALS, but the different methods, differently used medium, and difference in follow-up periods affect the outcome treatment. Methods: The current survey is a single-center, phase I clinical trial to evaluating the efficacy and safety of autologous bone marrow (BM)-derived MSCs through intrathecal administration in ALS patients. MNCs were isolated from BM specimens and cultured. The clinical outcome was evaluated based Revised Amyotrophic Lateral Sclerosis Functional Rating (ALSFRS-R) Scale. Results: Each patient received 15±3×106 cells through subarachnoid space. No adverse events (AEs) were detected. Just one patient experienced a mild headache after injection. Following injection, no new intradural cerebrospinal pathology transplant-related was observed. None of the patients’ pathologic disruptions following transplantation were detected by magnetic resonance imaging (MRI). The additional analyses have shown the average rate of ALSFRS-R score and forced vital capacity (FVC) reduction have decreased during 10 months following MSCs transplantation versus the pretreatment period, from -5.4±2.3 to -2±3.08 ALSFRS-R points/period (P=0.014) and -12.6±5.22% to -4.8±14.72%/period (P<0.001), respectively. Conclusion: These results have shown that autologous MSCs transplantation reduces the disease’s progression and has favorable safety. Trial Registration: This study performed as a phase I clinical trial (code IRCT20200828048551N1).
The predictive value of serum uric acid in development of acute kidney injury and mortality in patients with sepsis
Authors: Atef Moubarez Doaa
Published: April 2022

Introduction: Acute kidney injury (AKI) and sepsis are significant causes of morbidity and mortality in intensive care units. Therefore, early screening of high-risk individuals is critical for preventing AKI and improving outcomes. Objectives: To examine the possible involvement of uric acid in predicting AKI and mortality in septic patients. Patients and Methods: A prospective study recruited 400 patients with sepsis based on the quick Sequential Organ Failure Assessment (qSOFA) criteria who were hospitalized in the intensive care unit (ICU). Patients were categorized into two groups depending on their uric acid levels; those with a serum uric acid ≥7 mg/dL and those with a serum uric acid <7 mg/dL. Results: A total of 400 septic patients were included in this study. Among them, 52.5% (210/400) patients had hyperuricemia during admission to the ICU. A total of 177/400 (44.2%) patients developed AKI. The likelihood of having hyperuricemia in association with AKI was 65.6%. Meanwhile, the likelihood of having a uric acid level of less than 7 mg/dL in association with AKI was 23.9% (P<0.001). The mortality rate in the hyperuricemia group was substantially greater than in the normal uric acid level group (P<0.001). Uric acid levels higher than 7 mg/dL were significantly associated with AKI by multivariate logistic regression (P= 0.002). Receiver operating characteristic (ROC) curves revealed that uric acid has a high predictive value for AKI and ICU mortality in patients with sepsis. Conclusion: Serum uric acid could be a marker to predict AKI and mortality in patients with sepsis.
GRAPH ANALYTICAL MODEL AND MECHANISM FOR THE DEVELOPMENT OF AN INTELLECTUAL MAP OF TERMINOLOGICAL SYSTEMS IN THE FIELD OF PUBLIC ADMINISTRATION
Authors: Makrusev Viktor , Lyubkina Ekaterina
Published: April 2022

The study of the conceptual and terminological apparatus used in public administration, in particular, in the activities of the customs authorities of the Russian Federation, the analysis of the practice of its application and ways of further improvement in the conditions of development of state structures is an urgent scientific and practical task that requires appropriate scientific support for its solution. The authors have developed a graphoanalytic model and a mechanism for the formation of an intellectual map of terminological systems in the field of public administration; graphical tools for determining the dimension of knowledge and the expected effect of the implementation of the intellectual map project are presented. Such methods as system analysis, prototyping and cognitive modeling are proposed as the main ones in the formation of management term systems; the order of their application is determined. The possibilities of using intelligent digital technology for the construction of term systems are revealed. The integral concept of the formation of terminological systems in the context of the ambiguity of the conceptual apparatus of the concepts of public administration is formulated. On the example of the theory of customs administration, the needs for solving problems of terminological analysis, including in the process of transition to cognitive management technologies, are determined. The authors present the results of a study of theoretical positions and existing methodological approaches to the study and development of management term systems, a graphoanalytic model and a mechanism for the formation of an intellectual map of the term system.
ANALYSIS AND ACCOUNTING OF ELECTROMAGNETIC COMPATIBILITY AT THE SHORE STATION OF THE GLOBAL EMERGENCY MARINE COMMUNICATION SYSTEM WHEN PREDICTING THE RANGE OF RADIO COMMUNICATION IN THE MF BAND
Authors: ГРОМОЗДИН В.В. , ИЕВЛЕВ К.В. , КОЗУБ М.С.
Published: April 2022

Рассмотрена электромагнитная совместимость (ЭМС) берегового приемного оборудования СЧ-диапазона, обусловленная наличием близкорасположенных передающих устройств. Приведена методика расчетного и экспериментально-расчетного определения электродвижущей силы (ЭДС) внутренних шумов приемника, а также ЭДС, приведенной ко входу приемника, обусловленной внешними помехами из-за недостаточной ЭМС. Определен порядок использования полученных значений для прогнозирования дальности радиосвязи в направлении Судно-Берег с учетом ЭМС на береговой станции.

Electromagnetic compatibility (EMC) of onshore receiving equipment of the MF-band, due to the presence of nearby transmitting devices, is considered. A technique for calculating and experimentally calculating the determination of the electromotive force (EMF) of the internal noise of the receiver, as well as the EMF reduced to the receiver input and caused by external interference due to insufficient EMF, is presented. The procedure for using the obtained values for predicting the radio communication range in the ship-to-shore direction, taking into account EMC at the coast station, is determined.
Etiology of Drug-Resistant Epilepsy in Children: a One-Center Retrospective Cohort Study
Authors: Куликова С.Л. , Лихачев С.А. , Козырева И.В. , Белая С.А. , Иванов С.А. , Зайцев И.И. , Савченко М.А. , Попко Р.П. , Талабаев М.В. , Антоненко А.И. , Науменко Д.В. , Свинковская Т.В. , Овсянкина Г.И.
Published: April 2022

Под фармакорезистентной эпилепсией (ФРЭ) понимают эпилепсию, когда невозможно достичь устойчивого отсутствия эпилептических приступов при использовании двух хорошо переносимых, правильно подобранных в адекватных дозах противосудорожных лекарственных средств в монотерапии или в комбинации. Ретроспективно проанализированы истории болезни 287 пациентов с ФРЭ (139 девочек и 148 мальчиков) в возрасте от 0 до 18 лет, проходивших лечение в Республиканском научно-практическом центре неврологии и нейрохирургии (Минск) с 2014 по 2019 г. Установлены следующие причины развития ФРЭ в педиатрической популяции: 1) приобретенная структурная патология мозга (только структурная эпилепсия) 58 (20,2) наблюдений 2) врожденные пороки развития мозга (структурная генетическая) 70 (24,4) наблюдений 3) структурная патология вследствие перенесенного инфекционного заболевания с поражением ЦНС (структурная инфекционная) 15 (5,2) 4) врожденный порок развития мозга, сочетающийся с постинфекционными изменениями (структурная генетическая инфекционная) 1 (0,3) наблюдение 5) кистозно-атрофические изменения мозга вследствие наследственного заболевания нарушения обмена (структурная генетическая метаболическая) 1 (0,3) наблюдение 6) генетическая без структурного дефекта (генетическая) 66 (22,9) 7) генетическая и метаболическая 5 (1,7) наблюдений 8) аутоиммунная 1 (0,3) 9) неизвестная этиология 70 (24,4) наблюдений.

Drug-resistant epilepsy (DRE) is epilepsy when it is impossible to achieve a stable absence of epileptic seizures using two well-tolerated, correctly selected in adequate doses of anticonvulsant drugs in monotherapy or in combination. The clinical data of 287 patients with DRE (139 girls and 148 boys) aged 0 to 18 years who were treated at the Republican Research and Clinical Center of Neurology and Neurosurgery (Minsk) from 2014 to 2019 were retrospectively analyzed. The following causes of DRE in the pediatric population were established: 1) acquired structural brain pathology (structural epilepsy only) 58 (20.2) cases 2) congenital malformations of the brain (structural genetic) 70 (24.4) cases 3) structural pathology due to an infectious disease with damage to the central nervous system (structural infectious) 15 (5.2) 4) congenital malformation of the brain, combined with post-infectious changes (structural genetic infectious) 1 (0.3) observationcystic-atrophic changes in the brain due to a hereditary disease metabolic disorders (structural genetic metabolic) 1 (0.3) observation 6) genetic without structural defect (genetic) 66 (22.9) 7) genetic and metabolic 5 (1.7) cases 8) autoimmune 1 (0.3) 9) unknown etiology 70 (24.4) cases.
Dystrophic Myotonia of Rossolimo – Steinert – Kurshman, Sporadic Case. Clinical Observation
Authors: Лихачев С.А. , Астапенко А.В. , Марьенко И.П. , Корбут Т.В. , Степанова Е.С.
Published: April 2022

Дистрофическая миотония это генетически детерминированное нервно-мышечное заболевание, относящееся к каналопатиям (заболеваниям, связанным с патологией ионных каналов мембран скелетных мышечных волокон). Классическими признаками миотонии являются миотонические феномены, характеризующиеся замедленным расслаблением скелетных мышц после произвольного сокращения или электрической стимуляции и миотоническими разрядами, выявляемые при клиническом обследовании и игольчатой электромиографии соответственно. Типичным представителем является миотоническая дистрофия (или дистрофическая миотония), описанная в начале прошлого века несколькими авторами и получившая название болезни Россолимо Штейнерта Куршмана. Данная нозологическая единица является самым распространенным заболеванием из разряда миотоний и самой частой формой мышечной дистрофии у взрослых людей. Миотония может вовлекать все группы мышц. Однако характер поражения мышц может варьировать в зависимости от конкретного заболевания. В статье описаны этиология, патогенез, формы, диагностика и основные принципы лечения. Описан клинический случай.

Dystrophic myotonia is a genetically determined neuromuscular disease related to canalopathies (diseases associated with the pathology of the ion channels of the skeletal muscle fiber membranes). Classic signs of myotonia are myotonic phenomena characterized by delayed relaxation of skeletal muscles after arbitrary contraction or electrical stimulation and myotonic discharges detected during clinical examination and needle electromyography, respectively. A typical representative is myotonic dystrophy (or dystrophic myotonia), described at the beginning of the last century by several authors and called Rossolimo-Steinert-Kurschmann disease. This nosological unit is the most common disease of the category of myotonia and the most common form of muscular dystrophy in adults. Myotonia can involve all muscle groups. However, the nature of muscle damage may vary depending on the specific disease. The article describes the etiology, pathogenesis, forms, diagnosis, and basic principles of treatment. A clinical case is described.
Memantine in Treatment of Alzheimer’s Disease: week Comparative Randomized Open Clinical Trial of Memodex and Ebixa Drugs
Authors: Наумовская Н.А. , Лелявко И.А. , Голубева Т.С. , Старцев А.И. , Докукина Т.В.
Published: April 2022

Болезнь Альцгеймера (БА) является причиной 6070 всех случаев деменции. Мемантин одно из немногих средств, доказавших свою эффективность в лечении БА. В статье систематизированы сведения о механизмах действия и эффектах мемантина и представлены результаты 12-недельного рандомизированного открытого сравнительного клинического исследования двух препаратов мемантина (оригинального лекарственного средства Эбикса, производитель Lundbeck, и воспроизведенного Мемодекс, производитель Olainfarm) у пациентов (n64) с умеренной и тяжелой БА (519 баллов по шкале MMSE). После 12 недель лечения препаратами мемантина в дозе 20 мг в сутки в обеих сравниваемых группах достигнута положительная динамика по шкалам повседневной активности IADL и Краткой шкале оценки психического статуса MMSE. Отмечен положительный сдвиг по шкале CGI-S (клиническое глобальное впечатление тяжесть заболевания). Результаты испытания свидетельствуют об отсутствии статистически значимых различий в эффективности изученных лекарственных средств. Также не обнаружено различий в их переносимости, спектре, частоте и выраженности побочных реакций. Показано, что лекарственные средства Мемодекс и Эбикса обладают равнозначной клинической эффективностью и сопоставимой безопасностью.

Alzheimers disease (AD) accounts for 60-70 percent of all dementia cases. Memantine is one of the few medications that proved effectiveness in treating AD. This article contains systemized information about the modes of action and effects of memantine, and presents the results of the 12-week randomized open comparative clinical study of the effectiveness of two memantine drugs (brand-name drug Ebixa, produced by Lundbeck, and generic drug Memodex, produced by Olainfarm) taken by patients (n64) with moderately severe AD (MMSE 519). After 12 weeks of memantine therapy with a dose of 20 mg per day both comparable groups had positive changes according to the activities of Daily Living (IADL) and Mini-Mental State Examination (MMSE) scales. There is a positive shift according to CGI-S scale (Clinical Global Impression Severity). Besides, no statistically significant differences were found in the effectiveness of the studied drugs. Furthermore, no differences were found in acceptability, spectrum, as well as frequency and severity of side effects. The study demonstrated that pharmaceutical products Memodex and Ebixa have equal clinical effectiveness and similar safety characteristics.
PENGARUH STRATEGI PEMASARAN TERHADAP KEPUTUSAN PEMBELIAN BERAS HITAM (Oryza Sativa L. Indika) DI USAHA BERAS SEHAT “SAWAH BAIK CIANJUR”
Authors: Suryana Adang , Rizal Ahmad Nur , Hermawan Rendi
Published: April 2022

Akhir-akhir ini beras hitam mulai populer dan dikonsumsi oleh sebagian masyarakat sebagai bahan pangan fungsional karena secara alami atau melalui proses tertentu mengandung satu atau lebih senyawa yang dianggap mempunyai fungsi fisiologis yang bermanfaat bagi kesehatan, sehingga menjadi tren kesehatan bagi konsumen. Oleh karena itu selain faktor produk terhadap keputusan membeli konsumen tersebut faktor lain yang dapat dikontrol perusahaan untuk mempengaruhi keputusan membeli adalah 4P yaitu product (Produk), price (harga), promotion (Promosi), dan place/distribution (tempat). Tujuan pada penelitian ini adalah untuk mengetahui pengaruh setrategi pemasaran terhadap keputusan pembeli beras hitam (Oryza sativa L.Indica) diusaha beras sehat Sawah Baik Cianjur. Dengan responden sebanyak 60 menggunakan metode kuota sampling. Metode analisis yang digunakan adalah analisis linear berganda. Hasil penelitian ini menunjukan bahwa yang terkait strategi pemasaran terhadap keputusan pembelian adalah faktor produk mempunyai pengaruh yang positif dan tidak berpengaruh signifikan secara parsial, harga berpengaruh yang positif dan tidak berpengaruh signifikan secara parsial, promosi berpengaruh positif dan signifikan secara parsial dan tempat berpengaruh yang negatif dan tidak signifikan secara parsial. Pengaruh secara simultan, strategi pemasaran berpengaruh secara signifikan terhadap keputusan pembelian
PENGARUH KONSENTRASI EKSTRAK BAWANG MERAH (Allium cepa L.) TERHADAP PERTUMBUHAN AKAR STEK BATANG BAWAH MAWAR (Rosa Sp.) The Influence of difference onion extract (Allium cepa L.) to the root growth of rose rootsctock cuttings (Rosa Sp.)
Authors: Muhamad Alimudi Ramli &
Published: April 2022

Bibit tanaman mawar yang berkualitas baik dapat diperoleh melalui perbanyakan secara vegetatif dengan menggunakan stek batang bawah, tetapi metode ini memiliki kekurangan karena bibit yang berasal dari stek batang bawah tidak selamanya dapat menghasilkan persentase perakaran yang tinggi. Salah satu zat pengatur tumbuh alami yang dapat digunakan dalam pembibitan dengan menggunakan stek batang adalah perasan bawang merah, karena bawang merah mengandung zat pengatur tumbuh yang mempunyai peranan mirip Asam Indol Asetat (IAA). Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perbedaan konsentrasi ekstrak bawang merah terhadap pertumbuhan akar stek batang bawah mawar dan mengetahui konsentrasi ekstrak bawang merah yang dapat menghasilkan pertumbuhan akar stek batang bawah mawar paling baik. Parameter yang diamati adalah panjang akar, jumlah akar, berat basah akar, dan berat kering akar. Rancangan percobaan yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan 6 perlakuan dan 4 kelompok. Setiap unit percobaan menggunakan 3 buah stek batang. Perlakuan tersebut adalah ekstrak bawang merah konsentrasi 0%, 60%, 70%, 80%, 90%, dan 100%. Data yang diperoleh dianalisis dengan menggunakan analisis varians pada taraf kepercayaan 95% kemudian dilanjutkan dengan uji Tukey. Hasil penelitian menunjukan bahwa pemberian ekstrak bawang merah pada konsentrasi yang berbeda berpengaruh terhadap parameter panjang akar, jumlah akar, berat basah akar, dan berat kering akar. Ekstrak bawang merah dengan konsentrasi 70% menunjukan hasil yang optimal.
Faktor-Faktor Yang Mempengaruhi Konsumen dalam Pembelian Sayuran di Pasar Tradisional (Studi Kasus Pasar Muka Cianjur)
Authors: Rosda Malia Dedeh Siti Saodah &
Published: April 2022

Sayuran merupakan tanaman hortikultura yang memiliki nilai komersial yang cukup tinggi, serta memiliki potensi serapan pasar di dalam dan luar negeri yang terus meningkat. Sayuran saat ini telah mampu memasok kebutuhan konsumen dalam negeri melalui pasar tradisional dan pasar modern. Pasar-pasar modern mempunyai banyak kelebihan. Namun kehadiran pasar modern tidak mengurangi minat konsumen untuk berbelanja di pasar tradisional. Hal ini dapat diindikasikan bahwa keputusan konsumen terhadap pembelian sayuran di pasar tradisional masih tinggi. Tujuan penelitian ini adalah : 1) mengetahui pengaruh dari gaya hidup, sikap, kualitas, harga dan lokasi secara simultan terhadap keputusan pembelian sayuran di Pasar Muka Cianjur. 2) mengetahui pengaruh dari gaya hidup, sikap, kualitas, harga dan lokasi secara parsial 3) Untuk mengetahui faktor yang paling dominan berpengaruh terhadap keputusan pembelian sayuran di Pasar Muka Cianjur. Penelitian ini merupakan penelitian deskriptif kuantitatif yaitu memberi gambaran dan uraian pengaruh gaya hidup (X1), sikap (X2), kualitas (X3), harga (X4) dan lokasi (X5) terhadap keputusan pembelian (Y) sayuran, yang dianalisis menggunakan analisis jalur/ path analysis. Hasil analisis menunjukan bahwa : 1) variabel gaya hidup, sikap, kualitas, harga dan lokasisecara simultan berpengaruh signifikan terhadap keputusan pembelian 2) Variabel gaya hidup, harga dan lokasi secara parsial berpengaruh signifikan terhadap keputusan pembelian 3) variabel yang berpengaruh paling dominan adalah variabel gaya hidup.
PENGARUH KONSENTRASI ETANOL DAN LAMA WAKTU PERENDAMAN TERHADAP KEMAMPUAN DETEKSI NEMATODA SISTA KUNING ( Globodera spp)
Authors: Sri Nur Widyastuti Deni Indrawan & Pasetriyani &
Published: April 2022

Salah satu cara untuk deteksi awal identifikasi Nematoda Sista Kentang (NSK) pada lahan pertanaman kentang dengan metode Ekstraksi-isolasi nematoda. Tujuan penelitian ini adalah untuk mendapatkan konsentrasi dan lama waktu perendaman etanol yang tepat terhadap kemampuan mendeteksi NSK. Penelitian dilaksanakan di Laboratorium Pengawasan dan Sertifikasi Mutu Benih(PSMB) Tanaman Hortikultura pada Balai Pengawasan dan Sertifikasi Benih Tanaman Pangan dan Hortikultura (BPSBTPH) Provinsi Jawa Barat pada bulan Mei 2015. Metode penelitian yang digunakan adalah metode percobaan dengan RAK menggunakan 16 perlakuan dan setiap perlakuan terdiri dari 2 ulangan. Hasil percobaan menunjukkan jumlah sista NSK pada perendaman sampel tanah dalam larutan etanol 30 %, 60 %, dan 90 % kemampuanya dapat mendeteksi lebih tinggi berbeda nyata dibandingkan dengan kontrol (dengan perendaman sampel tanah dalam Aquadest dengan lama waktu perendaman 15, 30, 60, 90 menit). Perlakuan etanol 90 % dan lama waktu perendaman selama 30 menit paling baik dikarenakan daya angkat sista dipengaruhi oleh konsentrasi etanol, sehingga semakin pekat konsentrasinya maka semakin tinggi daya apungnya.
PENGARUH PERBANDINGAN SUBSTITUSI TEPUNG SUKUN DAN TEPUNG TERIGU DALAM PEMBUATAN ROTI MANIS
Authors: Poppy Diana Sari Lius Saepudin, & Yopi Setiawan &
Published: April 2022

Penelitian ini dibagi menjadi dua tahap, yaitu studi pendahuluan bahwa pembuatan tepung terigu dan analisis tepung sukun meliputi analisis fisika (warna dan tekstur tepung sukun), analisis kimia (analisis kadar pati). Penelitian utamanya adalah membuat roti manis, uji kekuatan bunga dan tes organoleptik. Membuat tepung sukun diawali dengan pengupasan kulit buah segar buah sukun matang, pembagian dan pembuangan bagian hatinya, serta potongan daging buah sukun untuk memudahkan lug. Sukun kemudian direndam dalam larutan natrium metabisulfit (Na2S2O5) sebesar 0,3% selama 2 -3 menit untuk mencegah kecoklatan. Setelah daging buah sukun di blansir pada suhu 80 ° C selama 10-20 menit, lalu dikeringkan di bawah sinar matahari lalu giling menggunakan pabrik disk untuk kemudian di sifter dengan sifter 60 mess. Penelitian dilakukan dengan membuat tepung sukun kemudian tepung sukun digunakan untuk membuat roti manis sebagai pengganti komposisi bahan tepung sukun 20%, 40%, 60%, 80% dan 100%. Kualitas roti manis kemudian di uji organoleptik oleh panelis 30 orang Hasil penelitian dapat ditemukan bahwa: (1) resep formula pada roti manis adalah dengan menggunakan tepung 80% dan tepung sukun 20%. (2) Hasil analisis kadar pati tepung sukun adalah 11,2667% dan analisis kadar pati dari sampel roti manis terbaik sebesar 8,0810% (3) Untuk mengetahui tingkat preferensi yang dimiliki. Uji produk terhadap 30 panelis menunjukkan bahwa produk dari tepung sukun menghasilkan tepung yang cocok untuk dikonsumsi. Dilihat dari komentar 30 panelis.
ATRIBUT MANISAN BUAH BASAH CIANJUR YANG MEMPENGARUHI PREFERENSI KONSUMEN
Authors: Lisarini Endah
Published: April 2022

Memasuki era Masyarakat Ekonomi Asean (MEA), pemerintah Republik Indonesia berupaya menjadi salah satu negara tujuan wisata. Sektor pariwisata terus digalakkan, salah satunya yang sangat marak dimajukan di berbagai daerah adalah wisata kuliner khas daerah. Indonesia yang terdiri dari banyak suku bangsa dan budaya, selaras dengan banyaknya ragam kuliner khas daerah, salah satunya kuliner asal Jawa Barat khususnya Cianjur yaitu manisan buah basah dan kering. Kesukaan konsumen akan manisan sangat beragam, oleh karena itu dilakukan penelitian dengan tujuan mengetahui atribut manisan buah basah Cianjur yang mempengaruhi preferensi konsumen dan mengetahui atribut manisan buah basah yang dominan mempengaruhi preferensi konsumen. Penelitian melibatkan 104 responden konsumen manisan buah basah yang secara aksidental sedang berkunjung dan membeli manisan buah basah tersebut. Tanggapan atas pertanyaan melalui kuesioner diolah dan dianalisis menggunakan Analisis Jalur. Analisis Jalur digunakan untuk mengetahui parsial dan simultan dari variabel eksogen terhadap variabel endogen. Pada penelitian ini yang dimaksud variabel eksogen adalah harga, rasa, keragaman, keawetan dari manisan buah basah dan sebagai variabel endogennya adalah preferensi. Hasil penelitian menunjukkan bahwa harga, keragaman dan keawetan manisan buah basah merupakan atribut yang berpengaruh signifikan secara parsial terhadap preferensi konsumen, namun secara simultan semua atribut produk (harga, rasa, keragaman, keawetan) berpengaruh signifikan terhadap preferensi konsumen. Dari ke empat atribut manisan buah basah, keawetan merupakan atribut yang paling dominan berpengaruh pada preferensi diikuti berturut-turut dengan keragaman dan harga.
TINGKAT ADOPSI PETANI TERHADAP PENERAPAN PADI PANDANWANGI ORGANIK (Studi Kasus di Desa Tegallega Kecamatan Warungkondang)
Authors: Rosda Malia Helmi Gerhana Putra &
Published: April 2022

Padi Pandanwangi organik merupakan padi lokal unggulan khas Kabupaten Cianjur. Di tengah minat masyarakat yang semakin tinggi akan pangan yang bersifat organik, sosialisasi pandanwangi organik sudah dilakukan sejak Tahun 2000 namun baru dilakukan oleh sebagian kecil petani. Sehingga perlu adanya suatu pengkajian mengenai tingkat adopsi, agar dapat memberi masukan bagi pengembangan Padi Pandanwangi organik. Penelitian ini bertujuan untuk mengetahui karakteristik sosial ekonomi petani Padi Pandanwangi organik dan mengetahui tingkat adopsi petani terhadap penerapan Padi Pandanwangi organik. Penelitian ini dilaksanakan di Desa Tegallega, pada bulan Maret sampai bulan Juli 2017. Analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan karakteristik sosial mayoritas responden berjenis kelamin laki-laki, berpendidikan SD, mempunyai luas lahan > 1 Ha, berpendapatan perbulan > Rp. 1.420.624, memiliki harta benda > Rp. 30.000.000 dan tingkat adopsi petani terhadap penerapan Padi Pandanwangi organik tergolong tinggi.
PENGARUH GA3 DAN BAP TERHADAP PERBANYAKAN TUNAS GERBERA JAMENSONII SECARA IN VITRO
Authors: Jamil Fauzi Awaludin , Imansyah Angga Adriana , Syamsiah Melissa
Published: April 2022

Tanaman Gerbera (Gerbera Jamensonii) merupakan tanaman hias yang diminati serta memiliki permintaan yang tinggi. Teknologi kultur jaringan merupakan teknologi yang tepat untuk memperoleh hasil percepatan benih yang berkualitas dengan penambahan ZPT (Zat Pengatur Tumbuh). ZPT yang digunakan adalah kombinasi GA (Asam Giberelat) dan BAP (Benzyl Amino Purine). Penelitian ini dilaksanakan pada bulan Juli sampai Agustus 2020, bertempat di Balai Penelitian Tanaman Hias (BALITHI) Segunung. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi GA (Asam Giberelat) dan BAP (Benzyl Amino Purine) terhadap multiplikasi tanaman Gerbera. Rancangan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap (RAL) faktorial yang terdiri dari 4 taraf perlakuan dengan masing masing perlakuan terdapat 3 sampel. Parameter penelitian ini meliputi, jumlah tunas, jumlah daun dan panjang daun. Hasil penelitian menunjukan bahwa pemberian G1S1 (GA 3 ppm dan BAP 0,5 ppm) merupakan perlakuan yang paling baik yang mampu menstimulus jumlah tunas dan jumlah daun Gerbera (Gerbera Jamensonii).