bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis of Logistic Regression, LSTM, and Bi-LSTM Models for Sentiment Analysis on IMDB Movie Reviews
Authors: Mureed Hussain  , Naseer Mudasser
Published: January 2025

This study examines the efficacy of three distinct machine learning models for sentiment analysis: Bidirectional Long Short-Term Memory (Bi-LSTM), Long Short-Term Memory (LSTM), and Logistic Regression. One of the most important tasks in natural language processing is sentiment analysis, which entails categorizing reviews as positive or negative. Fifty thousand sentiment-labeled movie reviews make up the dataset. To determine the most precise and effective technique for sentiment categorization, we put these models into practice and evaluated their respective performances. The highest accuracy of 89.42% is achieved by Logistic Regression, with precision of 88.35%, recall of 91.01%, and F1-score of 89.66%. The LSTM model, well-known for capturing temporal dependencies in text, obtained an accuracy of 86.23%, precision of 89.60%, recall of 82.22%, and an F1-score of 85.75%. The Bi-LSTM model, which processes input sequences in both forward and backward directions to better capture context, demonstrated accuracy of 87.65%, precision of 88.67%, recall of 86.54%, and an F1-score of 87.60%. The results show that although Logistic Regression performs better in accuracy, the Bi-LSTM model offers a substantial trade-off between precision and recall, making it a viable option for sentiment analysis applications. Despite its minor accuracy lag, the LSTM model provides important insights into the sequential relationships of the text data.
Obstructive Nephropathy from Misplaced Suprapubic Catheter with Antegrade Migration into the Urethra
Authors: Lipinski Alexander , Pollock Jordan Riley , Tan Nelly , Rappaport Douglas
Published: January 2025

Case Presentation: An 83-year-old male with a history of prostate cancer and prior prostatectomy presented with lower abdominal pain, urethral leakage, and hematuria after a routine suprapubic catheter exchange, which was found to be incorrectly positioned in the bulbar urethra, leading obstructive nephropathy with mild hydronephrosis. Discussion: This case highlights the increased risk of suprapubic catheter misplacement and complications in elderly patients with neurogenic bladder and altered urinary anatomy, particularly after prostatectomy and artificial urethral sphincter placement. It emphasizes the importance of careful management during catheter exchanges in such patients to prevent complications of misplacement.
Melatonin Aids in Treating Mood and Sleep Problems Resulting from Hormonal Therapy in Breast Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial
Authors: Vaziri Nima , Shakourifar Melika , Sattari Parinaz , Sadeghi Aliereza , Sharifi Mehran , Moghadas Ayda , Moghaddas Azadeh
Published: January 2025

Background: Hormone therapy is commonly used to treat breast cancer but can cause mood disorders and sleep disturbances, negatively impacting patients' well-being. Objectives: This trial aimed to evaluate the effects of melatonin on sleep problems and mood changes in breast cancer patients undergoing hormone therapy. Methods: The study was conducted at Omid Hospital in Isfahan, Iran, using a randomized, double-blinded, placebo-controlled design. Participants were assessed using the Hospital Anxiety and Depression Scale (HADS) and were randomly assigned to receive either 6 mg of melatonin or a placebo daily for 4 weeks. Sleep quality, depression levels, and mood states were measured using the Pittsburgh Sleep Quality Index (PSQI), the Center for Epidemiological Studies-Depression Scale (CES-D), and the Profile of Mood States (POMS) Questionnaires at the beginning and end of the 4-week follow-ups. Results: Sixty participants (34 in the melatonin group and 26 in the placebo group) completed the study. Melatonin administration significantly improved sleep quality, latency, duration, and reduced the use of sleep-promoting medication, according to the PSQI scores. However, there were no significant improvements in depression severity or mood disorders, as assessed by the CES-D and POMS questionnaires, in either group following the 4-week melatonin supplementation period. Conclusions: Melatonin supplementation effectively alleviated sleep disturbances caused by hormone therapy in breast cancer patients. However, the study did not find substantial evidence supporting the use of melatonin for improving mood disorders or depression in this specific context.
Bupropion Showed Neuroprotective Impacts Against Cerebral Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation
Authors: Baba Ahmadi Saeid , Afrand Khalilabad Zeinab , Alemohammad Seyedeh Sepideh , Yousefi Manesh Hasan , Abdollahi Alireza , Jazayeri Farahnaz , Mousavi Seyyedeh Elaheh
Published: January 2025

Background: Cerebral ischemia/reperfusion (I/R) injury is the most prevalent form of brain stroke, affecting many patients worldwide. It is believed that oxidative stress and inflammation play major roles in the damage that occurs after the initiation of the disease. Objectives: Therefore, for the first time, the current study aimed to investigate the neuroprotective effects of bupropion against cerebral I/R damage in a rat model. Methods: Forty male rats were divided into four groups: Control, cerebral I/R, and two diseased groups that received 60 and 100 mg/kg of bupropion. One day after induction of the disease, behavioral tests, including grid walking, novel object recognition, and modified neurological severity score (mNSS), were performed on the rats. The levels of inflammatory cytokines, including IL-1β, TNF-α, IL-6, and IL-10, were measured in the rats' brain homogenates. Additionally, the levels of MDA, catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and NO2- were measured. Results: Bupropion administration was associated with improved performance in the novel object recognition and grid walking behavioral tests, as well as in the neurological disorder scores, in cerebral I/R rats. Moreover, BCAAO-induced inflammation was reduced by the administration of this drug, evidenced by reduced levels of cytokines IL-1β, TNF-α, and IL-6 and upregulation of IL-10. Additionally, membrane lipid peroxidation was reduced in the cerebral I/R rats receiving 100 mg/kg bupropion, and the level of SOD activity was improved in these animals. Finally, the administration of bupropion prevented the increase in NO2- levels induced by BCAAO. Conclusions: In conclusion, bupropion has neuroprotective effects against cerebral I/R damage by reducing inflammation and oxidative stress in the brain.
Sosyal Bilgiler Dersinde Harita Okuryazarlığı ve Önemi
Authors: Avcı Merve
Published: January 2025

Sosyal Bilgiler dersinde harita okuryazarlığı oldukça önemli bir yere sahiptir. Özellikle ülkelerin ve bölgelerin öğrenciler tarafından anlaşılabilir bir hâle gelmesinde harita bilgisinin ve harita okuryazarlığının iyi bir şekilde kavranması önem arz etmektedir. Haritadaki renklerden, işaretlerden, sembollerden ve harita lejantından yola çıkarak harita üzerinde yorumlama yapma, analiz ve değerlendirme süreçlerinin tamamı harita okuryazarlığı olarak isimlendirilir. Harita okuryazarlığı ile bireylerin mekânı algılamaları ve yer-olay bağlantısı kurabilmeleri daha da kolaylaşır. Harita okuryazarlığı sayesinde öğrenciler sadece kendi mekânları hakkında bilgi sahibi olmazlar, aynı zamanda diğer mekânlar ve bölgeler hakkında da bilgi edinebilir, harita okuryazarlığı ile haritadan alması gereken bilgi ve becerilerle kendilerini geliştirebilirler. Bu anlamda Sosyal Bilgiler dersinde sıklıkla kullanılan haritalar ve bu haritaların kullanım amacını kavrayan öğrenciler ile dersler daha etkili bir şekilde işlenebilir. Harita okuryazarlığının geliştirilmesi ve haritanın derslerde daha etkin bir şekilde kullanılması ile Sosyal Bilgiler dersinde öğrenilen bilgilerin ve kavramların daha kalıcı olması sağlanacak, etkin öğrenme ortamı oluşacaktır. Bu anlamda harita okuma becerisi ve harita kullanımı önemli bir konumda yer almaktadır. Bu çalışmada da Sosyal Bilgiler dersinde harita kullanımının ve harita okuryazarlığının önemine değinilmiş, harita okuryazarlığı ile etkin bir öğrenme ortamının sağlanacağı üzerinde durulmuştur.
الجيوماتكس واللاتماثل من الظاهرة الى الإستراتيجية
Authors: زهراء حسن كاظم
Published: January 2025

منذ بزوغ فجر العصر الحديث وفلاسفة السياسة عاكفون على مناقشة علاقة الدولة بالظروف التي تجد نفسها فيها، تبعاً لحيوية دورها في استجلاء الظواهر وصور فاعليتها ونمطيتها المتغيرة وبما يفضي الى تغيّر وتعدد الوظائف للقوى الدولية. هذهِ الظواهر بتواترها ظلّت متبدّلة ومتحكمة في مقومات متداخلة التأثير والأثر ومصالح متفاوتة ومطامح مسوّغة لأفعال إستراتيجية تتطرف احياناً وتنتظم أخرى لتأتي بأنماط أداء استراتيجي متجدد تلوح بنتائجها على مجمل تفاعلات النظام العالمي، والمبادلة الفعلية للمواقف، والأداء الموازي لرد التهديدات، لتندفع بالإجمال الى تغيير التوازن الاستراتيجي العالمي.
Mi travesía en la UAN: de sueños a realidades
Authors: Aguilar Ventura Diego Alberto
Published: January 2025

Mi trayectoria en la UAN, desde mis sueños infantiles hasta mi presente como docente, refleja el poder transformador de la educación. A pesar de los desafíos, la UAN es un faro de esperanza, formando profesionales comprometidos y contribuyendo a un futuro mejor.
Mi acercamiento al Dr. Julián Gascón y a la Universidad Autónoma de Nayarit
Authors: Casillas Alcalá Dra. María Teresa
Published: January 2025

El Dr. Julián Gascón Mercado es sin lugar a dudas una figura emblemática en la historia del estado de Nayarit, siendo el fundador de la Universidad Autónoma del mismo estado, su legado lleva 55 años de inquebrantable esfuerzo, dejando al final de cada año escolar miles de estudiantes que se han formado en las aulas. La razón principal de fundar esta escuela dicho por él, es “para que los estudiantes no sufran al alejarse de su familia, de su estado, lo que yo sufrí”
Roots of Sentience
Authors: Kee Hayden ,   International Association for Environmental Philosophy
Published: January 2025

Can we empathize with plants? Critics object that supposed empathy with plants entails anthropomorphic or zoomorphic projection. In reply, a phenomenological account of empathy claims to avoid this objection. However, phenomenological accounts of empathy center on one sentient (phenomenally conscious) mind accessing another. If plants are not sentient, then they appear to be inappropriate targets for empathy. I reply by exploring how the organic body is implicated in sentience, even if it is not usually focal. Interoceptive experience gives us indirect access to our own organic body, and thus provides a basis for a problematic, paradoxical empathy with plants.
Construction of PPP (Partai Persatuan Pembangunan) and PKS (Partai Keadilan Sejahtera) Thought in Understanding Terrorism
Authors: Atjih Sukaesih  , Yudi Martha Nugraha  , Kodarni
Published: January 2025

This article specifically explains the construction of PPP and PKS's thinking in interpreting terrorism. These two parties are the largest Islamic parties in Indonesia and almost all of their supporters are Muslims. The qualitative research method used in selecting informants or subjects has been selected purposively based on their activities, with the consideration that those selected as informants can explore and articulate their experiences consciously in interviews conducted by the Researcher through written texts sent and received via Whatsapp and email. The conclusions from the results of this study are (1) the reality of terrorism is socially formed; (2) the reality of terrorism is expressed through language; (3) knowledge of terrorism is obtained through social processes; and (4) emphasizes real action with suicide bombings. PPP firmly stated that there are two main roots of the problem, namely the problem of religious and economic understanding. Meanwhile, PKS firmly believes that terrorism is caused by the motive of economic inequality. To judge the issue and actions of terrorism is left to the Government and religious experts who understand the Law/Regulations and religious affairs only, considering that they do not want to make statements that will harm the existence of the Party in the future. Their task as the largest Islamic Political Party in Indonesia is only to monitor, supervise and calm the unrest in society through their representatives in each branch and region by coordinating and providing understanding and knowledge about terrorism issues and actions.
A Social and Cultural Analysis of Computer-mediated Communication Dialog in Asian Contexts
Authors: WU Pin-hsiang Natalie , LIU Shih-min
Published: January 2025

The present study analyzes how social and cultural contexts influence the CMC interactions in a cross-cultural English collaborative learning project for university participants from Taiwan, Japan, and Korea. The main purpose of the study is to understand how social and cultural differences, manipulated by one’s social and cultural context and interest toward international affair, influence the CMC dialogues among students of Asia, and how attitudes differ from one cultural group to another. The web platform communication tool used in this study was an online classroom established by Nicenet organization (www.nicenet.org). The project employed a qualitative research methodology using NVivo 9 digital software to analyze social and cultural aspects of the CMC dialogues. The results show that intergroup climate does play an important role in cross-cultural asynchronous CMC projects. Unfamiliarity among participants can present a constant influence on the flow of interaction, and feedback giving, which decreases motivation for participants from different cultural groups.
Collaborative Languaging for L1 Learning in a CSCL Classroom via Group Scribbles: An Exploratory Case Study
Authors: CHEN Wenli , XIE Wenting , LOOI CheeKit
Published: January 2025

A micro-generic case study has been conducted to explore students’ collaborative languaging practices in a CSCL L1 classroom. Descriptive analysis shows that students were highly engaged in the collaborative task and their group work was efficiently coordinated, during which required linguistic forms of accuracy and appropriateness were constructed, so did the related linguistic knowledge. This reveals the significance of collaborative languaging and technology intervention to enhance learning in L1 classrooms.
Design Principles for a Pedagogically-Sound Mobile-Enabled Language Learning System
Authors: PALALAS Agnieszka
Published: January 2025

This paper provides a brief overview of a longitudinal Design-Based Research study conducted with ESP students and practitioners at a Canadian college. The study resulted in two key outcomes, namely the Mobile-Enabled Language Learning EcoSystem and corresponding design principles. The design guidelines presented in this paper focus on the pedagogical aspects of the mobile-enabled intervention viewed through an ecological lens. The purpose of this paper is to introduce practical guidelines for language teachers and instructional designers who seek to develop m-learning solutions.
Practical Use of Triangle Block Model for Bridging between Problem and Solution in Arithmetic Word Problems
Authors: HIRASHIMA Tsukasa , FURUKUBO Kazutoshi , YAMAMOTO Sho , Yusuke Yusuke , MAEDA Kazushige
Published: January 2025

This paper reports a practical use of triangle block model for learning of arithmetic word problems. The triangle block model has been proposed as a bridging model between conceptual representation of a word problem and quantitative representation of its solution. Based on this model, we have developed an interactive environment where a pupil is able to manipulate an integrated representation of the conceptual and quantitative ones as learning of arithmetic word problems. We also designed a series of lessons to use the environment. The lessons were practically conducted for 75 4th grade pupils (in two classes) in an elementary school for 7 class times. As the results, it was confirmed that (1) the pupils and their responsible teacher accepted the lessons as useful ones, and (2) the lessons had learning effect as improvement of structural understanding for the problems.
Multitask Learning for Chinese Grammatical Error Detection
Authors: ZHOU Yu-jie , ZHOU Yong
Published: January 2025

Chinese as a Foreign Language (CFL) learners often make grammatical errors such as missing words, selecting wrong words and wrong word order due to language negative migration. In this paper, we propose a neural sequence labeling model with a supplementary objective for Chinese grammatical error detection. We use the manually labeled dataset written by CFL learners to train the models. This multitask learning model has better performance than other sequence labeling model because it can learn the bias in the label distribution and learn richer features for semantic composition.
Teaching System for Operation of Artificial Respirator
Authors: KANEHIRA Ren , ITO Yasuhiro , KATO Masanao , MIWA Naoki , FUJIMOTO Hideo
Published: January 2025

This study deals with a computer supported teaching system for artificial respirator operation. The system is characterized by the capability of learning both operation techniques and related medical textbook knowledge. Effort was given on the improvement of proficiency and trouble-shooting during practice. After a certain teaching practice, the effect of the system was verified with experiments. Obtained results were well feed-backed for some adjustment and improvement in the system for better teaching effects. Useful hints for new approach to technical teaching in medical machine operation has been obtained through our sequential work of the proposal, construction, teaching practice and effect verification of the system.
Gamified Learning Objects for Inclusive Programming and Science Education
Authors: GARG Saumay , MITTAL Seema , GOYAL Mukta
Published: January 2025

Children from low-income communities face additional barriers to science and computing education, including limited computer access, language barriers, and a lack of resources for experimentation, often while being out of school. Computer-based learning resources that address these challenges in their design have the potential to make STEM education accessible to a whole new section of society. This paper presents a gamified learning object and a supporting visual programming language (VPL) that allows users to program and execute science experiments in the form of a narrative-driven problem-solving exercise. This tool is primarily intended for children from economically disadvantaged backgrounds.
Epistemic Network Analysis to assess collaborative engagement in Knowledge Building discourse
Authors: Ong Aloysius , Teo Chew Lee , Lee Alwyn Vwen Yen , Yuan Guangji
Published: January 2025

Knowledge Building (KB) is an established learning sciences theory that seeks to promote innovative ideas and idea improvement among students via collaborative engagement in productive discourse. KB discourse supports students to make constructive discourse moves such as questioning, explaining with evidence, adding new information and so on, to advance the collective inquiry. However, current understanding on KB discourse remains limited to students’ online participation. Although small group discussion is a common practice, there is little understanding on the role of verbal discussions to support KB discourse. This paper attempts to address this line of inquiry by assessing student engagement in KB discourse supported by both online and verbal discussions. Data is retrieved from a group of six students in a Grade 6 Social Studies class. The group participated in a 2.5hr lesson designed with opportunities for discussions on the Knowledge Forum (online) and in small groups (verbal). Group talk was transcribed, and Knowledge Forum notes were coded for its semantic level of contribution, with the codes being analysed for weighted connections using Epistemic Network Analysis (ENA). The ENA analysis revealed clear differences in both group and individual engagement between the online and verbal discourse. Notably, students’ contributions on Knowledge Forum showed an apparent pattern of stronger connections among codes of higher semantic levels, suggesting that students were more cognitively engaged in the online discussion than their group verbal talk. Implications for research and practice are discussed.
Enhancing student teachers’ collaborative interdisciplinary design through knowledge-building activities
Authors: LIN Pei-Yi
Published: January 2025

This study aims to investigate student teachers’ interdisciplinary design collaboration and integrated teacher knowledge in a knowledge-building environment. A class of 14 participants was divided into four groups to discuss interdisciplinary learning design ideas using Knowledge Forum. Data include (1) a pre- and post- questionnaire designed to investigate the participants' interdisciplinary design capacities (e.g., teacher efficacy, epistemic fluency, interdisciplinary design communication, integrated teacher professional knowledge) and (2) records of online activities such as numbers of notes generated, modified, and read. The findings showed that student teachers’ perception of teacher efficacy to design interdisciplinary learning, epistemic understanding, interdisciplinary design communication, pedagogical content knowledge (PCK), technological pedagogical knowledge (TPK), and integrated technological, pedagogical, and content knowledge (TPACK) were significantly enhanced. The online knowledge-building activities were more likely to relate to student teachers’ epistemic understanding and integrated teacher knowledge (i.e., TCK and TPK). The significance of practice-based, design-oriented activities for developing interdisciplinary collaboration in teacher preparation is discussed.
From Individual Ideation to Group Knowledge Co-Construction: Comparison of High- and Low- performing Groups
Authors: CHEN Wenli , SU Guo , LI Xinyi , LYU Qianru , SU Junzhu , CHAI Siew Cheng Aileen , NG Eng Eng
Published: January 2025

This study compares the high- and low-performing groups’ knowledge co- construction process in the context of computer-supported collaborative argumentation from epistemic, argument, and social perspectives. Product analysis, lag sequential analysis, Sankey diagram visualization, and social network analysis were used to analyze groups’ written argumentation artefacts, on-screen behaviors, and online interactions. Results show that the high-performing group students demonstrated a higher level of engagement and cognitive elaboration than the low-performing group. The high-performing group was more competent in integrating various argumentation elements than the low-performing group. And the students in the high-performing group tended to contribute equally to their group work. The implications of the findings in designing and implementing knowledge co-construction activities are discussed.
Analysis of algorithmic strategy development in the development of computational thinking of upper elementary school students
Authors: WANG Xiaowen , HU Pinqi , CHEN Guang
Published: January 2025

Computational thinking has become a thinking ability that we need to master in our daily lives. Programming is a way to cultivate computational thinking. This study focuses on the algorithmic links of senior primary school students in programming activities, puts forward a hierarchical table of algorithmic strategies, and analyzes their strategic development paths according to their programming behaviors.In this paper, Swift Playgrounds, developed by Apple Company, is selected as the tool of programming activities, and three levels are selected as the teaching content in the three theme activities of Learning Programming 1 in Swift Playgrounds software. The target audience of the activities is the senior (fourth to sixth grade) students in primary schools. This paper studies the design of the micro-generation method, carries out programming activities based on computational thinking for students through pre-test, practice, post-test and migration stages, and collects data by interview and classroom observation so as to analyze the development path of students' algorithm strategies in different stages and the change track of algorithm strategies in each stage.This study provides some support for teachers' teaching in programming teaching activities.
A rare case of unilateral facial infiltrating lipomatosis: summary of medical and dental implications
Authors: Bode Dr. Ayoola , Aslam Dr. Fawad , O'Kane Dr. Donal , McIntosh Dr. Angela , Humphreys Dr. A. Karen
Published: January 2025

Introduction

Facial infiltrating lipomatosis (FIL) is a rare congenital and benign condition, resulting from mature nonencapsulated adipocytes penetrating into neighbouring structures. Individuals with FIL present with unilateral facial and craniofacial hemihypertrophy, alongside various medical and dental complications of the affected side.

Case report

At birth, the infant had an evident right sided facial swelling which remained asymptomatic but continued to increase in size. Magnetic resonance imaging confirmed right-sided lipomatous hyperplasia and genetic testing confirmed a somatic mutation to PIK3CA; the cause of cell hyperproliferation, often identified in FIL cases. On the right side, the child has developed epidermal naevus and mild hearing and visual impairment. A multidisciplinary team (paediatric medicine and dentistry, dermatology, ENT and plastics at Great Ormond Street Hospital) has contributed to managing the complex condition. At 12 months old, paediatric dentistry observed premature eruption of teeth 53, 54 and 84 and hyperplasia of the upper right alveolar arch. At 5 years-old, the child presented with premature exfoliation of primary teeth and premature eruption of permanent teeth 14, 16, 41, 42 and 46 with bilateral crossbites.

Management

A dental prevention regime has been implemented and the child remains caries free. The developing dentition will continue to be monitored with consideration of orthodontic management. Presently, as the child remains stable, a conservative approach without surgical or medical intervention has been adopted. His vision is corrected with glasses.

Conclusion

FIL is associated with dental developmental anomalies and medical complications of the affected side, requiring multidisciplinary care.
MANİ VE HOYRATLAR
Authors: Süleymanova Leman
Published: January 2025

Mani (bayatı) Türk poetik düşüncesinin en önemli kalıplarından biridir. Bu türün bir diğer spesifik özelliği de sadece Türk folkloruna ait olmasıdır. Türklerle komşu olarak yaşayan topluluklar da maniyi Türkçe söylerler. Sözlü edebiyatın bu türü, değişik adlar altında çeşitli Türk boylarında mevcuttur. Mani şiirsel kalıbının adları değişik olsa da, fonksiyonu aynıdır. Bu tür ister bayatı adlansın, ister hoyrat, ister mani vb. niteliği değişmez. Maninin bağlamı, fonksiyonu, musiki ile bağlılığı gibi meseleler bütün Türk halklarında aynıdır.
Makalede Azerbaycan manileri ile Türkmeneli hoyratları karşılaştırılmakta, onların farklı ve benzer yönleri ele alınmaktadır. Azerbaycan manilerinin Türkmeneli hoyratları ile fonksiyonları tamamen aynıdır. Ama onların konu ve şekil bakımından bazı farkları vardır. Türkmeneli hoyratlarının arasında siyasi konuda olan hoyratlar daha fazladır. Bunun nedeni son yüzyılda Irak Türkmenler’inin baskı altında yaşamaları, toprak kaybetmeleri, kendi yurtlarında hor görülmeleri, zorunlu göçlere tabi tutulmaları vs. olmuştur. Irak Türkmenler’indeki hoyratların bir kısmının altı ve sekkiz mısralı olduğunu görüyoruz. Azerbaycan’dan derlenmiş manilerde ise mısra sayı genellikle dörtten fazla değildir. Bu makalede Azerbaycan bayatıları ile Irak Türkmenler’inde mevcut olan hoyratlar araştırılmakta ve bu manilerin spesifik yönleri analiz edilmektedir.
BPCA as a Model for Government-Sponsored Drug Repurposing
Authors: Kesselheim Aaron , Liu Ian
Published: January 2025

Drug repurposing can include the application of previously approved prescription drugs to new medical conditions and has been proposed as a lower-cost and less-risky approach to developing useful new treatments for patients, since widespread experience with a drug can help provide signals of potential activity and safety profile. There have been numerous examples of successful drug repurposing, such as thalidomide for multiple myeloma and colchicine for cardiovascular disease.

Despite the promise of the idea, there is concern that drug repurposing is under-used. Explanations include that drug repurposing provides little financial incentive for manufacturers to pursue such development,
1 especially compared to the potentially lucrative market exclusivities associated with bringing new products to market.

One solution to help stimulate greater repurposing could be public funding of necessary clinical trials, such as through the National Institutes of Health (NIH). A successful legislative model for running such studies is the 409(i) provision of the Best Pharmaceuticals for Children Act (BPCA).
Perancangan sistem dan prosedur penjualan tunai di Toko J LU Fashion Manado
Authors: Paat Victoria Maria , Pontoh Winston , Pinatik Sherly
Published: January 2025

Despite the integration of technology in sales management systems, many businesses still rely on manual cash sales systems and procedures. This study aims to address this by examining the cash sales system and procedures at J LU Fashion Store. The research method used is a qualitative approach with data collection techniques, including interviews, observations, and documentation. The results are clear: at J LU Fashion Store, the cash sales accounting information system, financial calculations, and sales records are still all done manually. There are no guidelines or SOPs to help the company, meaning the sales process in the store is not optimal.
MODEL QUANTUM LEARNING UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA DI MADARASAH IBTIDAIYAH SEI BEROMBANG
Authors: Haris Suwondo
Published: January 2025

Dalam dunia pendidikan selalu ada saja permasalahan yang dapat menghambatmotivasi anak dalam hal belajar, salah satunya yaitu kurangnya kemampuan guruuntuk memotivasi itu sendiri dan pada akhirnya siswa menjadi tidak bergairahdalam belajar, cendrung acuh tak acuh sehingga mengakibatkan hasil belajaryang kurang maksimal. Bertolak dari kasus tersebut maka penulis berupaya untukmenanamkan kembali gairah belajar siswa dengan cara memotivasi mereka melaluimodel quantum learning, sesuai namanya “quantum” yang diadopsi dari pelajaranilmu Fisika yang artinya interaksi yang mengubah energy menjadi cahaya. Dalamhal ini quantum lerning yaitu model yang dapat merubah berbagai interaksi menjadisebuah kegiatan belajar, Dari analogi tersebut Quantum leraning juga bisa dikatakansemua proses belajar yang dapat mengasah pengetahuan dan daya pikir siswa, sertadapat membuat sebuah pembelajaran menjadi hal yang menyenangkan dan tentunyabermanfaat.Pelajaran matematika bagi sebagian peserta didik adalah sebuah pelajaranyang menakutkan, hal ini dikarenakan ketidak pahaman peserta didik mengenaimateri yang terdapat pada pelajaran Matematika. Ketidak pahaman itulah yangharus dientaskan oleh guru, jika peserta didik sudah paham maka mereka akanbisa menyukai pelajaran matematika. Maka yang harus dilakukan oleh guru adalahbagaimana peserta didik bisa menyukai pelajaran matematika, caranya adalahdengan menggunakan model pembelajaran yang menyenangkan yang membuatpeserta didik merasa nyaman dan tenang dalam mempelajari sebuah materi pelajaran.Model quantum dapat merubah berbagai interaksi menjadi sebuah kegiatan belajar,Dari analogi tersebut Quantum leraning juga bisa dikatakan semua proses belajaryang dapat mengasah pengetahuan dan daya pikir siswa, serta dapat.
ANALISIS PERSPEKTIF QAWAID FIQHIYYAH FATWA TENTANG SANKSI ATAS NASABAH MAMPU YANG MENUNDA-NUNDA PEMBAYARAN MENURUT PRINSIP SYARIAH
Authors: Galih Orlando
Published: January 2025

act—AbstakKeungan syariah didasari dengan adanya keinginan memperbaiki etikaperekonomian agar Al-Qur’an dan As-Sunnah di implementasikan dalam segalaaspek kehidupan. Adanya anggapan bahwa fiqih belum selesai memberikan solusihukum atas permasalahan-permasalahan yang ada. Adanya konflik dan keteganganantara praktek dan teori dalam penerapan hukum Islam. Hal ini diawali oleh NegaraPakistan dan Malaysia di tahun 1940-an, yaitu pengelolaan dana jamaah hajisecara Syariah. Selanjutnya dalam tatanan sebuah lembaga diawali oleh IslamicRural Bank di desa Mit Ghamr pada tahun 1963 di Kairo, Mesir, perintis tersebutmenjadikan bank Islam percontohan dan berkembang. Perkembangan selanjutnyamuncul fenomena sikap menunda-nunda pembayaran oleh debitur terhadap bankyang memberi fasilitas pembiayaan. Akibatnya bank mengalami kerugian karenadalam melakukan penagihan, bank mengeluarkan biaya, mulai dari masalahadministrasi, sampai biaya yang besar dan biaya lainnya. Masalah dalam penelitianini dirumuskan berdasarkan logika deduktif, yaitu bagaimana analisis perspektifqawaidh fiqih terhadap lahirnya fatwa DSN NO 17 DSN MUI IX 2000.Dalam upaya menjawab permasalahan yang di kemukakan dalam pokokmasalah di atas maka peneliti menggunakan pendekatan qawaidh Fiqih danSosiologis. Ada beberapa perbedaan pendapat ulama fiqih. Sebagian berpendapatbahwa hukuman denda tidak boleh digunakan, dan sebagian lagi berpendapat bolehdigunakan. Ulama Mazhab Hambali, termasuk Ibnu Taimiyah dan Ibnu Qayyimal-HukumanJawziah, mayoritas ulama Mazhab Maliki, ulama Mazhab Hanafi, dansebagian ulama dari kalangan mazhab Syafi’i berpendapat bahwa seorang hakimdapat menetapkan hukuman denda terhadap suatu tindak pidana ta’zir̄. Di Indonesiamasih terdapat beberapa perbedaan pendapat para pakar, baik pakar hukum Islammaupun pakar ekonomi Islam. Hal ini dilatarbelakangi beberapa hal, menurut ulama kontemporer yang membolehkandenda finansial termasuk DSN MUI,memperbolehkan diberlakukan dendafinansial di lembaga keuangan syariah(seperti bank syariah) sebagai ta’zirkepada nasabah yang mampu namunmenunda pembayaran utangnya
KEKUATAN DAN KELEMAHAN PEMBELAJARAN MELALUI DARING PADA MASA COVID – 19 DI MTs. SWASTA AL-BUKHARY RANTAUPRAPAT
Authors: Bukhari Is  , Suryatik
Published: January 2025

Pendidikan mempunyai peranan penting dalam hidup dan kehidupan manusiaoleh karena itu proses pendidikan atau pembelajaran harus berjalan dengan baikdan dilaksanakan sesuai dengan kondisi dan situasi pada waktu tersebut karenakriteria pengelompokan negara maju dan negara berkembang salah satunyadidasarkan pada masalah pendidikan. Bank Dunia berfokus dalam mendukungRencana Strategis (Renstra) dengan portofolio pinjaman investasi pendidikananak usia dini, pendidikan dasar, pendidikan tinggi dan pendidikan informal.Dalam situasi pandemi Covid 19 pendidikan harus berjalan dengan lancer denganmenggunakan berbagai metode dan bantuan teknologi sehingga lahirlah modelpembelajaran dengan menggunakan jaringan internet (daring), namun disadaribahwa teknologi tidak dapat menggantikan guru dalam proses pembelajaran, danproses pembelajaran harus terlaksana dengan baik.Pelaksanakan pembelajaran daring adalah salah satu model pembelajaranyang dilakukan pada masa pandemi, karena dalam prinsip kebijakan pendidikan dimasa pandemi Covid-19 adalah mengutamakan kesehatan dan keselamatan parapeserta didik, para pendidik, tenaga kependidikan, keluarga, dan masyarakat padaumumnya, dalam rangka pemenuhan layanan pendidikan selama masa pandemi.Corona adalah penyakit menular yang disebabkan oleh jenis corona virus yang baruditemukan dan penyakit yang tidak dikenal sebelum terjadi wabah di Wuhan. Istilahsebutan virus ini adalah Covid-19 yang merupakan singkatan dari CoronaVirus Disease-2019.Masa Covid-19 harus terlaksanadengan baik oleh kare a itu prosespembelajaran dengan memaksimalkanfasilitas internet sehingga newnormaldapat terlaksana dengan baik. Dapatproses pembelajaran melalui daringmemerlukan kesadaran belajar yangtinggi dengan bantuan orang tuadirumah untuk memberi motivasibelajar anak. Sehingga belajar anakdapat maksimal.
PELATIHAN LITERASI DIGITAL BAGI PARA GURU SD INPRES 2 ARSO 1 KABUPATEN KEEROM
Authors: Tayane Rosalin Theophilia , Marianingsih Susi , Widodo Widodo , Palumpun Yulius
Published: January 2025

Artikel ini membahas tentang pemberdayaan sumber daya guru melalui pelatihan literasi digital berbasis TIK menggunakan aplikasi Canva. Tim Pengabdian kepada Masyarakat (PKM) dari Universitas Sains Dan Teknologi Jayapura (USTJ) menyelenggarakan pelatihan ini selama dua hari dengan melibatkan para guru dari SD Inpres 2 Arso 1. Dengan pendekatan praktik, peserta diberikan kesempatan untuk mempelajari dan menggunakan berbagai fitur Canva untuk membuat media pembelajaran, seperti poster dan video. Hasil evaluasi menunjukkan adanya peningkatan pemahaman dan keterampilan peserta secara signifikan. Sebanyak 90% peserta merasa lebih percaya diri dalam membuat materi pembelajaran digital setelah mengikuti pelatihan. Namun, terdapat beberapa kendala seperti akses internet yang tidak stabil dan perbedaan tingkat pemahaman peserta terhadap teknologi. Untuk mengatasi kendala tersebut, tim pelaksana memberikan pendampingan tambahan dan materi pelatihan yang dapat diakses secara luring. Melalui pelatihan ini, diharapkan para guru dapat memanfaatkan teknologi untuk memperkaya proses pembelajaran dan meningkatkan mutu pendidikan di Papua. Artikel ini juga menekankan pentingnya keberlanjutan dan perluasan program pelatihan ke sekolah lain sehingga dapat memberikan dampak positif bagi proses belajar mengajar di era digital. Pemberdayaan guru melalui literasi digital diharapkan dapat meningkatkan kompetensi mereka dalam menghadapi tantangan pendidikan modern.
Kata kunci: Canva, pelatihan, guru
EL MONITOREO DE AVES MIGRATORIAS NEÁRTICO-NEOTROPICALES EN SU TEMPORADA NO REPRODUCTIVA: ÉXITOS, DESAFÍOS, Y NUEVAS INICIATIVAS DEL PROGRAMA MOSI
Authors: Albert Steven , Ash Abidas , Quintero Félix Raul Said , Fernández-Ordóñez Juan Carlos
Published: January 2025

Aproximadamente la mitad de las aves que anidan en Canadá y Estados Unidos migran al Neotrópico durante la temporada no reproductiva, pasando entre seis y nueve meses en sus zonas de invernada. De manera similar, alrededor de un tercio de la avifauna de México migra hacia el norte, a Canadá y Estados Unidos, durante la temporada de nidificación, que ocurre entre abril y agosto. La conservación de las aves migratorias Neotropicales es una responsabilidad compartida por todos los países y personas de las Américas. Desde 1989, el Programa MoSI, una red de cooperadores independientes administrado por el Institute for Bird Populations, trabaja para entender la ecología de las aves migratorias durante su temporada no reproductiva. En los últimos años, el programa ha tenido un crecimiento notable, tanto en el número de participantes como en los sub-programas que ha instituido.
THE STUDY OF BIRD VOCALIZATIONS IN NEOTROPICAL HABITATS: CURRENT KNOWLEDGE AND FUTURE STEPS
Authors: Sandoval Luis , Graham Brendan , Sosa-López J. Roberto , Laverde-R. Oscar , Araya-Ajoy Yimen G.
Published: January 2025

Research on avian bioacoustics in the Neotropics has surged over the last several decades due to increased interest in the large diversity of vocal behaviors and vocalization and the broader accessibility of recording equipment and software. Here, we present a synthesis of the current and past knowledge of Neotropical bird bioacoustics. This synthesis is the result of the symposium "Bioacoustics in the Neotropics", organized for the XI Neotropical Ornithological Congress in San Jose, Costa Rica, in July 2019. We covered what we consider the main topics in avian bioacoustics that have been studied in this region over the last 30 years. Our review includes repertoire descriptions, geographic variation, diversity in vocal behaviors, seasonality, duetting, genetic association, and playback experiments. Additionally, we present information for what we believe may be the main veins of investigation for the coming future in the Neotropics, considering the large diversity of species that are found in the region and the new investigations developed in other geographic areas. We expect this review to work as a summary of the current literature and a guide to stimulate future research in important areas within the field of avian bioacoustics in the Neotropics.
Bridging the English Proficiency Gap: The Higher Education Challenges of Bangla-Medium Students in Bangladesh
Authors: Mridula Kashpia Afroz , bin Ahsan Wahid
Published: January 2025

This study examines the challenges Bangla-medium students in Bangladesh face when transitioning to English-based higher education. Despite over a decade of English instruction, many struggle with comprehension, academic writing, and classroom engagement due to exam-oriented learning, ineffective pedagogy, and limited exposure to spoken English. Socioeconomic disparities further widen the language gap, restricting access to English-medium education and supplementary learning resources. Using a qualitative approach, semi-structured interviews with 15 students, teachers, and guardians explored their experiences. Thematic analysis identified key barriers, including reliance on rote memorization, limited communicative teaching, and inconsistent language use in universities. The findings highlight the need for curriculum reforms, teacher training in communicative methods, structured university support, and targeted policy interventions to improve students’ academic success and career readiness.
Regional Comparative Analysis of Family Catastrophic Health Expenditure in Pakistan
Authors: Saif Ullah  , Dr. Abdur Rehman  , Dr. Muhammad Niamat Ullah Khan Babar  , Dr. Farman Ullah Khan  , Muhammad Waqar  , Shehla Mazhar  , Bushra Zaman  , Saima Munir  , Muhammad Eshan Elahi
Published: January 2025

The amount of money Pakistani families spend on medical care is examined in this paper making use of PSLM data for 2018–19. It looks into the elements and factors that affect how much money families spend on various illnesses. Numerous factors, such as the type of disease, the number of people living in different provinces, the location (rural or urban) and age of the family heads affect the cost of a family's catastrophic expenditure. According to the estimation results, it can be concluded that in light of all factors have a positive influence on policy recommendations for health expenditure. Furthermore, any finding could have a broad impact on health expenditure of Pakistan. Each of these elements has a distinct impact on how the government determines what amount of funding to allocate to the health sector. The regression was conducted using regression analysis and the ordinary least squares (OLS) method. This method and technique are used in specific situations when the dependent variable in a model is quantitative. Estimates and results will be used to develop the policy and find solutions for every issue that can be attributed to the variables and household health spending.
Chatbot Efforts: Unveiling the Influence on Customer-Brand Connections
Authors: Hafsa Malik  , Javaria Asim
Published: January 2025

The present study researches the multifaceted dynamics of chatbot marketing initiatives concerning their influences related to quality of communication and customer-brand relationship. It also researches their impacts on loyalty response and brand advocacy within the clothing and apparel industry of Pakistan. This study adopts a quantitative approach using probability sampling. It examines communication quality and customer-brand relationship as mediators in the improvement of customer loyalty to response and advocacy, using the perspective of chatbot interactions. Data from the sample of 304 heterogeneous apparel consumers revealed significant relations among these variables of interest. Data analysis using SmartPLS 4.0 was therefore done, and from this analysis, it was realized that the chatbot marketing efforts have had positive effects on communication quality, hence enhancing the relationships between customers and the brand. These relationships drive customer loyalty, response, and brand advocacy to a significant extent, and therefore confirm that chatbots are indeed a tool for improving customer experience. Most importantly, through the proposed mediation analysis, communication quality and customer-brand relationship were identified as two imperative pathways that help retrieve more improved customer loyalty and advocacy for chatbot marketing efforts. This study contributes to chatbot marketing theory by explaining the mechanisms that drive consumer behavior in digital environments.
Enhancing Corporate Reputation and Brand Equity through CSR: The Mediating Influence of Consumer Trust
Authors: Hammad Zafar  , Fakhre Alam Siddiqui  , Abdul Basit
Published: January 2025

The empirical foundation of this study is the perception of Pakistani retail banking industry customers as it relates to CSR initiatives and their effects on two crucial intangible assets and marketing outcomes: referred to as corporate reputation (CR) and brand equity (BE). Through the survey of banking consumers, it was possible to carry out the study with the help of 162 valid responses. To investigate the hypothesis, we applied structural equation modeling—statistical method. Moreover, CSR has a positive influence on the CR in the short and long run. Another finding made is the fact that CSR has no impact on Brand Equity (BE). Furthermore, it is also seen that mediating player trust has significant moderating effect on the relationship between CSR and brand equity and between CSR and corporate reputation. The argued evidence shows that a firm’s reputation and brand equity increases with improved consumers’ trust to the CSR programs. The implications of the results are significant for Pakistani retail banks and indicate that CSR activities can enhance institutions’ reputation.
Effect of Teachers’ Competencies on Students' Academic Achievement: A Comparative Analysis of Public and Private Universities, Lahore
Authors: Fajar Nadeem  , Husna Imran  , Iqra Asim
Published: January 2025

Teachers' competencies encompass the essential skills, knowledge, and dispositions that enable educators to effectively enhance students’ learning and academic performance. These competencies play a crucial role in shaping the educational environment by directly influencing students' performances and their overall academic success. Therefore, this study aims to assess the effect of teachers' competencies on the academic performance of students enrolled in public and private universities located in Lahore, Pakistan. The sample surveyed comprised 313 respondents, with 166 being public university students and 147 private university students. Evaluation of Teaching Performance Questionnaire (CEID) measures several dimensions of instructional effectiveness to assess the respective students. A non-probability sampling technique was adopted and the data gathered were analyzed using inferential statistical methods. The results indicated that teacher qualifications and competencies are two of the main factors affecting the improved academic performance of students. Importantly, from a comparative perspective, there is no marked difference between public and private schools in terms of the competencies of instructors. Schools are encouraged to allocate more resources to professional development programs, focusing on enhancing teachers' instructional skills and disciplinary knowledge in areas requiring improvement. Additionally, further research is essential to track changes in teacher training and their potential impact on improving students' academic performance.