bluuebunny/crossref_metadata_2025 huggingface dataset:
ULTRA-HIGH SENSITIVITY VANADIUM–VANADIUM SESQUIOXIDE–VANADIUM (V–V2O3–V) SYMMETRIC TUNNEL JUNCTION DIODE
Authors: ABDEL-RAHMAN MOHAMED
Published: September 2018

In this paper, a symmetrical MIM tunnel junction diode with a novel material combination, vanadium–vanadium sequioxide–vanadium (V–V2O3–V) is fabricated and electrically characterized. Analysis of the measured current-voltage ([Formula: see text]–[Formula: see text] characteristics of the fabricated MIM diode revealed an ultra-high diode sensitivity of [Formula: see text]9.24[Formula: see text][Formula: see text] at an applied bias of [Formula: see text]0.104[Formula: see text]V. Based on the measured [Formula: see text]–[Formula: see text] characteristics, theoretical predictions were performed showing that the diode’s dynamic resistance can be tuned for matching to coupled antennas, in rectenna structures, whilst maintaining high levels of sensitivities using practically realizable V2O3 insulator thicknesses.
A NOVEL METHOD FOR RAPID FABRICATION OF PMMA MICROFLUIDIC CHIP BY LASER CUTTING AND SEALING INTEGRATION
Authors: CHEN XUEYE , LI TIECHUAN , GAO QI
Published: September 2018

In this paper, we present a new method that is capable of manufacturing microfluidic chips of polymethyl methacrylate (PMMA) rapidly and cheaply. This technique, which we call Tape adhering-Laser Cutting and Sealing Integration (TLCSI), only utilizes a CO2 laser and a piece of double-sided tape to produce a microfluidic chip in several minutes. It only has three main steps. First, the double-sided tape sticks to the surface of a PMMA substrate. Second, the microchannel should be cut on the surface of the double-sided tape. At last, a PMMA cover plate with liquid pools is pressed onto the surface of the double-sided tape and a CO2 laser is used to cut edges of the chip for sealing the chip. We present a qualified microfluidic chip with regular microchannels and sealing strength of 1.2[Formula: see text]Mpa. Compared with most current fabrication methods, TLCSI is a quick and cost-effective way to produce microfluidic chips of PMMA.
SELF-SURFACE WRINKLING ATOP ACRYLONITRILE BUTADIENE STYRENE (ABS) VIA HEATING-RESPONSIVE SHAPE MEMORY EFFECT
Authors: SUN LI , WANG TAO XI , BIN MOHD ZAKEE MUHAMMAD HAIRUL IZWAN , BIN ROSLI MUHAMMAD SYAZWAN , LEE YUN XIANG , HUANG WEI MIN
Published: September 2018

In this paper, first we investigate the heating-responsive shape memory effect in an acrylonitrile butadiene styrene (ABS). Subsequently, after surface treatment (via dipping in acetone/water solution of different concentrations and for different dipping time) of pre-stretched samples, we demonstrate the feasibility to form strip shaped wrinkles atop the surface upon heating of pre-stretched ABS for shape recovery. The influential factors, such as acetone concentration and dipping time in surface treatment, are revealed and discussed.
Hybrid Isogeometric-Finite Element Discretization Applied to Stress Concentration Problems
Authors: Maleki-Jebeli Saeed , Mosavi-Mashhadi Mahmoud , Baghani Mostafa
Published: September 2018

Isogeometric analysis (IGA) employs non-uniform rational B-splines (NURBS) or other B-spline-based variants to represent both the geometry and the field variable. Exact geometry representation and higher order global continuity (at least [Formula: see text] even on elements’ boundaries) are two favorable properties that would make IGA an appropriate discretization technique in problems with responses associated with the derivatives of the primary field variable. As a category of these problems, in this paper, 2D elastostatic problems involving stress concentration sites are analyzed with a hybrid isogeometric-finite element (IG-FE) discretization. To exploit higher order continuity of NURBS basis functions, IGA discretization is applied selectively at pre-identified locations of high displacement gradients where the stress concentration occurs. In addition, considering computational efficiency, the rest of problem domain is discretized by means of linear Lagrangian finite elements. The connection of NURBS and Lagrangian domain is carried out through employing specially devised elements [Corbett, C. J. and Sauer, R. A. [2014] “NURBS-enriched contact finite elements”, Computer Methods in Applied Mechanics and Engineering 275, 55–75]. The methodology is applied in some 2D elastostatic examples. Increasing the number of DOFs and comparing convergence of the concentrated stress value using different discretizations, it is shown that the hybrid IG-FE discretizations generally have faster and more stable convergence response compared with pure FE discretizations especially at lower DOFs.
High capacity VO2(B) nanostrips synthesized by microwave-hydrothermal method
Authors: Yang Zi , Liu Yongchuan , Li Feng , Yin Qingya , Lou Youxin , Sun Jian
Published: September 2018

VO2(B) nanostrips were synthesized by microwave-hydrothermal method. The XRD patterns show that VO2(B) nanostrips are pure metastable monoclinic phase. VO2(B) nanostrips, in length of 1.5–2[Formula: see text][Formula: see text]m, width of 200–400[Formula: see text]nm, and thickness of 10–20[Formula: see text]nm, present exposed (001) facets and parallel alignment structure. The VO2(B) nanostrips are composed of nanosheets with 2–5[Formula: see text]nm thickness. A very high initial discharge capacity of 318.3[Formula: see text]mAh[Formula: see text]g[Formula: see text] is obtained and the capacity of 100th cycle is 248.5[Formula: see text]mAh[Formula: see text]g[Formula: see text] (about 78.0% retention) at 50[Formula: see text]mA[Formula: see text]g[Formula: see text]. The capacity fades at about 4.08% per cycle for the first 10 cycles. After 10 cycles, the fading slows down to 0.32% per cycle. The rate performance shows the first discharge capacities of VO2(B) nanostrips are 249.6, 212.0, 181.8, 161.7, and 145.2[Formula: see text]mAh[Formula: see text]g[Formula: see text] at 0.1, 0.2, 0.4, 0.8, and 1.6[Formula: see text]A[Formula: see text]g[Formula: see text], respectively, with around 100% coulombic efficiency. Glycerol and microwave-hydrothermal method contribute to the shaping and thickness of VO2(B) nanostrips with the parallel alignment nanostructure, which directly improves the electrical properties of this material.
Prenatal Steroids and Metabolic Dysfunction: Lessons from Sheep
Authors: Cardoso Rodolfo C. , Padmanabhan Vasantha
Published: September 2018

Prenatal exposure to excess steroids or steroid mimics can disrupt the normal developmental trajectory of organ systems, culminating in adult disease. The metabolic system is particularly susceptible to the deleterious effects of prenatal steroid excess. Studies in sheep demonstrate that prenatal exposure to excess native steroids or endocrine-disrupting chemicals with steroidogenic activity, such as bisphenol A, results in postnatal development of numerous cardiometabolic perturbations, including insulin resistance, increased adiposity, altered adipocyte size and distribution, and hypertension. The similarities in the phenotypic outcomes programmed by these different prenatal insults suggest that common mechanisms may be involved, and these may include hormonal imbalances (e.g., hyperandrogenism and hyperinsulinemia), oxidative stress, inflammation, lipotoxicity, and epigenetic alterations. Animal models, including the sheep, provide mechanistic insight into the metabolic repercussions associated with prenatal steroid exposure and represent valuable research tools in understanding human health and disease. Focusing on the sheep model, this review summarizes the cardiometabolic perturbations programmed by prenatal exposure to different native steroids and steroid mimics and discusses the potential mechanisms underlying the development of adverse outcomes.
Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies
Authors: Caruso Joseph A. , Duong Mylinh T. , Carey Jason P. W. , Hunt Kelly K. , Keyomarsi Khandan
Published: September 2018

Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (CDK2), is central to the initiation of DNA replication at the G1/S checkpoint. Tight temporal control of cyclin E is essential to the coordination of cell-cycle processes and the maintenance of genome integrity. Overexpression of cyclin E in human tumors was first observed in the 1990s and led to the identification of oncogenic roles for deregulated cyclin E in experimental models. A decade later, low-molecular-weight cyclin E (LMW-E) isoforms were observed in aggressive tumor subtypes. Compared with full-length cyclin E, LMW-E hyperactivates CDK2 through increased complex stability and resistance to the endogenous inhibitors p21CIP1 and p27KIP1. LMW-E is predominantly generated by neutrophil elastase–mediated proteolytic cleavage, which eliminates the N-terminal cyclin E nuclear localization signal and promotes cyclin E's accumulation in the cytoplasm. Compared with full-length cyclin E, the aberrant localization and unique stereochemistry of LMW-E dramatically alters the substrate specificity and selectivity of CDK2, increasing tumorigenicity in experimental models. Cytoplasmic LMW-E, which can be assessed by IHC, is prognostic of poor survival and predicts resistance to standard therapies in patients with cancer. These patients may benefit from therapeutic modalities targeting the altered biochemistry of LMW-E or its associated vulnerabilities. Cancer Res; 78(19); 5481–91. ©2018 AACR.
Bowen’s Disease of the Nipple
Authors: Kitahara Miyuki , Hozumi Yasuo , Watanabe Akie  , Iijima Tatsuo
Published: September 2018

Bowen’s disease is a type of intraepidermal squamous cell carcinoma that commonly develops in areas of the skin exposed to sunlight, such as the scalp, trunk, and limbs. Although development of Bowen’s disease in other sites, such as the nipple, is extremely rare, we herein report our experience with one such case. A 76-year-old female presented to our hospital with complaints of right nipple pruritus. We diagnosed Bowen’s disease via nipple skin biopsy, and the patient underwent right nipple resection. The deep tissue margin was positive for malignancy; therefore, the patient subsequently underwent right partial mastectomy. Histopathology revealed tumor cells inside the lactiferous ducts, but the resection margin was negative for malignancy. Bowen’s disease of the nipple may progress from the skin to the lactiferous ducts. Clinical findings can be used to evaluate lesion progression and determine the necessary extent of skin and mammary gland resection.
Discovery and Characterization of a High-Affinity Small Peptide Ligand, H1, Targeting FGFR2IIIc for Skin Wound Healing
Authors: Zhao Ying , Wang Qiang , Jin Yuan , Li Yadan , Nie Changjun , Huang Peipei , Li Zhixin , Zhang Bihui , Su Zijian , Hong An , Chen Xiaojia
Published: September 2018

Background/Aims: How to aid recovery from severe skin injuries, such as burns, chronic or radiation ulcers, and trauma, is a critical clinical problem. Current treatment methods remain limited, and the discovery of ideal wound-healing therapeutics has been a focus of research. Functional recombinant proteins such as basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) have been developed for skin repair, however, some disadvantages in their use remain. This study reports the discovery of a novel small peptide targeting fibroblast growth factor receptor 2 IIIc (FGFR2IIIc) as a potential candidate for skin wound healing. Methods: A phage-displayed peptide library was used for biopanning FGFR2IIIc-targeting small peptides. The selected small peptides binding to FGFR2IIIc were qualitatively evaluated by an enzyme-linked immunosorbent assay. Their biological function was detected by a cell proliferation assay. Among them, an optimized small peptide named H1 was selected for further study. The affinity of the H1 peptide and FGFR2IIIc was determined by an isothermal titration calorimetry device. The ability of theH1 peptide to promote skin wound repair was investigated using an endothelial cell tube formation assay and wound healing scratch assay in vitro. Subsequently, the H1 peptide was assessed using a rat skin full-thickness wound model and chorioallantoic membrane (CAM) assays in vivo. To explore its molecular mechanisms, RNA-Seq, quantitative real-time PCR, and western blot assays were performed. Computer molecular simulations were also conducted to analyze the binding model. Results: We identified a novel FGFR2IIIc-targeting small peptide, called H1, with 7 amino acid residues using phage display. H1 had high binding affinity with FGFR2IIIc. The H1 peptide promoted the proliferation and motility of fibroblasts and vascular endothelial cells in vitro. In addition, the H1 peptide enhanced angiogenesis in the chick chorioallantoic membrane and accelerated wound healing in a rat full-thickness wound model in vivo. The H1 peptide activated both the PI3K-AKT and MAPK-ERK1/2 pathways and simultaneously increased the secretion of vascular endothelial growth factor. Computer analysis demonstrated that the model of H1 peptide binding to FGFR2IIIc was similar to that of FGF2 and FGFR2IIIc. Conclusion: The H1 peptide has a high affinity for FGFR2IIIc and shows potential as a wound healing agent. As a substitute for bFGF, it could be developed into a novel therapeutic candidate for skin wound repair in the future.
Inhibition of the Notch Signaling Pathway Reduces the Differentiation of Hepatic Progenitor Cells into Cholangiocytes in Biliary Atresia
Authors: Mao Yongzhong , Tang Shaotao  , Yang Li , Li Kang
Published: September 2018

Background/Aims: Viral infections, especially with rotavirus, are often considered an initiator of the pathogenesis of biliary atresia (BA). However, the mechanism by which rotavirus induces BA is still unclear. Methods: A BA mouse model was induced in newborn mice by i.p. inoculation with rhesus rotavirus within 6 h of birth. The expression of Notch pathway-associated molecules (JAG1, JAG2, Notch1, Notch2, Notch3, Notch4, DII1, DII3, and DII4) was measured by quantitative PCR and western blot analysis. Bile duct obstruction was detected by hematoxylin and eosin staining and CK-19 immunohistochemical staining. DAPT was used to inhibit the Notch pathway in vivo and in vitro. Results: In the livers of patients with BA and rotavirus-induced BA mice, the expression of JAG1 and Notch2 was significantly increased. Inhibition of the Notch pathway by DAPT in vivo ameliorated bile duct obstruction and delayed BA-induced mortality. The serum levels of inflammation cytokines (TNF-α, IL-2, IL-8, and IL-18) were reduced by inhibiting the Notch pathway. The expression of CK19, Sox9, and EpCAM was significantly increased in BA liver, while DAPT treatment decreased the expression of CK19, Sox9, and EpCAM. Conclusion: Notch activation is involved in the pathogenesis of BA by promoting the differentiation of hepatic progenitor cells into cholangiocytes.
ОСОБЛИВОСТІ ІМУННОГО ГОМЕОСТАЗУ В ДИНАМІЦІ РОЗВИТКУ ЕКСПЕРИМЕНТАЛЬНОЇ БРОНХІАЛЬНОЇ АСТМИ
Authors: Reheda M. S. , Lubinets L. A. , Shchepanskyi B. F.
Published: September 2018

In this paper, it is shown that the modeling process of bronchial asthma (BA ) is accompanied by changes, in comparison with the control group, in the indicators of immune system response: T- & B-lymphocytes, circulating immune complexes in blood of guinea pig males on the 4th, 18th, 25th day of experiment.The aim of the study – determination of some indices of immune system in blood of guinea pigs in the modeling process of BA on 4th, 18th, 25th day of the experiment.Materials and Methods. Experiments were conducted on 40 guinea pigs (males), with body weight 0.25–0.27 kg. Animals were divided into four groups of ten animals in each. Intact guinea pigs were the first group. Animals with experimental BA – the second, third, fourth group respectively on the 4th, 18th, 25th day of the experiment. Experimental BA was reproduced by V. I. Babych method. In blood of intact guinea pigs and animals with experimental BA , the number of T- and B-lymphocytes was determined by the method of E. F. Chernushenko, L. S. Kohosov, determination of the level of circulating immune complexes was carried out by the method of V. Haskova and co-authors. The results of the study were processed by the method of variation statistics using Student's criterion.Results and Discussion. The results of the studies showed unidirectional changes in individual parameters of the immune system, depending on the periods of the formation of BA : an increase in the number of B-lymphocytes and circulating immune complexes, a decrease in the number of T-lymphocytes for all of the studied days of the experiment.Conclusions. The obtained results indicate significant changes in the immune system parameters in the blood of experimental animals with BA and are important for understanding the pathogenesis of BA . These studies provide an opportunity to find the more perfect and effective methods of diagnosis of BA.
ФЕРИТИН, ЗАПАЛЕННЯ ТА ФРФ-23 ПРИ ХРОНІЧНІЙ ХВОРОБІ НИРОК
Authors: Chaikovska M. I.
Published: September 2018

Fibroblast-23 growth factor (FGF-23) is a phosphate-regulating hormone secreted mainly by osteocytes, the level of which increases in response to an increase in the concentration of phosphates in the development of renal failure. Although FRG -23 helps to prevent hyperphosphataemia, its elevated level is independently associated with vascular dysfunction, left ventricular hypertrophy, an increased risk of CVD , and death in patients with chronic kidney disease (CKD).The aim of the study – to learn the status of systemic inflammation in CKD by measuring the levels of CRP and ferritin and to investigate the relationship between FRF-23 and inflammatory markers in CKD.Materials and Methods. The study involved 106 people, 47 women (44 %) and 59 men (56 %), age (49.6±13.9) years with CKD. Laboratory studies included determination of ferritin, CRP , hemoglobin (N). The C-terminal fragment of FRF-23 was determined using a set of reagents for the immuno-enzymatic analysis "Biomedica" on the apparatus STAT FAK 303 Plus.Results and Discussion. In the examination of patients with CKD, progressive elevation of CRP from CKD I (0.95 mg/l) to CKD V (25.7 mg/l) (p<0.001) in parallel with the development of renal failure was observed. The study of ferritin сoncentration showed a significant increase in its level already at the CKD stage II (167.23 ng/ml), compared with CKD stage I (57.53 ng/ml) (p<0.05), and achievement of maximum values at the terminal stage of chronic renal failure (285.1 ng/ml) (p<0.001). A negative correlation was found between ferritin and hemoglobin (R = - 0.37; p<0.001), since its concentration decreased from CKD I (141 g/l) to CKD V (88 g/l) (p<0.001). The concentration of the C-terminal fragment FGF-23 progressively increased in parallel with the GFR decline, reaching the highest values at the CKD stage V (p<0.001). A positive correlation was found between the concentration of ferritin and CRP (R = 0.41; p<0.001).Conclusions. The serum ferritin level increases in parallel with the decrease in GFR and has a significant negative correlation with hemoglobin concentration and positive correlation with the level of CRP and FGF-23 in patients with CKD. The serum ferritin level is not able to independently reflect the body's supply of iron in the CKD and can serve as a marker of inflammation in this patient cohort. The serum concentration of CRP increases in parallel with the decrease in GFR, reaching maximum values at CKD V, and has a significant positive correlation with the level of FGF-23 at CKD.
ПОРУШЕННЯ ВАРІАБЕЛЬНОСТІ СЕРЦЕВОГО РИТМУ ЯК МЕТОД ОЦІНЮВАННЯ АДАПТАЦІЙНИХ РЕАКЦІЙ ОРГАНІЗМУ ВАГІТНИХ ПРИ НАЯВНОСТІ ШКІДЛИВИХ ЗВИЧОК
Authors: Korniienko V. H. , Fitkalo A. S.
Published: September 2018

According to modern data, the cardiovascular system is a kind of indicator of the organism's adaptive activity, and the structure of the heart rhythm carries information about the development of adaptive reactions in response to irritating factors of the external and internal environment.The aim of the study – to investigate the functional state of the autonomic nervous system in pregnant women who have harmful habits by evaluating and analyzing the parameters of heart rate variability in order to prevent complications of non-delivery of gestational process.Materials and Methods. The study involved 73 pregnant women, 53 of them were pregnant (the main group) who had malignant habits in history. Before studying adaptive reactions in pregnant women, a study of cardiac rhythm variability was performed in practically healthy non-pregnant women of reproductive age (25.3±2.2) years). The control group consisted of 20 pregnant women without any harmful habits. Determination of heart rate variability was performed on the basis of peripheral heart rate recording, which included measuring the sequence of RR intervals for 5 minutes, followed by mathematical analysis using the PlsMntr software product.Results and Discussion. It was established that in the main group, in the complicated failure to pass the gestational process, violations of cardiac rhythm variability were detected in 59.7 % of cases. There is an increase in the frequency of very low frequency (VL F) waves (43.5 % relative to control, p<0.05), indicating a predominance of humoral and metabolic rate of regulation of the cardiac rhythm. At the threat of premature births, a decrease in the particle (LF) is observed at 36.6 %, a decrease in the share of high-frequency waves (НF) by 30.8 %. Taking into account the results of the study, one can speak of a decrease in the tone of the sympathetic and parasympathetic nervous system, reducing the influence of the reflexive vegetative level of regulation, which, in turn, indicates the depletion of regulatory mechanisms and the lack of an adaptive protective effect of n.vagus on the heart.Conclusions. Our innovative low-invasive method of evaluating the adaptive reactions of the organism through the determination and analysis of indicators of cardiac rhythm variability in pregnant women with the existing harmful habits offers us the opportunity to observe manifestations of functional stress of regulatory systems of pregnant women, preceding the development of complication of non-delivery of gestational process.
МОРФОМЕТРИЧНІ ОСОБЛИВОСТІ СТІНОК ШЛУНОЧКІВ ТА МІЖШЛУНОЧКОВОЇ ПЕРЕГОРОДКИ СЕРЦЯ ЩУРІВ У НОРМІ ТА ПІСЛЯ ВНУТРІШНЬОПЛІДНОЇ ДІЇ АНТИГЕНУ
Authors: Hryhorieva O. A. , Cherniavskyi A. V.
Published: September 2018

Recently diseases of cardiovascular system in children take one of the first places in Ukraine.The aim of the study – studying the morphometric features of walls and interventricular septum thickness of rat’s heart in normal conditions and after antenatal antigen impact.Materials and Methods. 144 hearts of laboratory rats were investigated. They were divided into 3 groups: I group – intact rats, ІІ – control group, that get intrauterine injection of Sodium Chloride solution 0.9 % 0.05 ml on the 18th day of antenatal development. III – the experimental group of rats, who were injected by 0.05 ml of anatoxin in a similar method. Serial sections were stained with hematoxylin and eosin.Results and Discussion. In the experimental group in newborn animals the indices of the thickness of right ventricle, left ventricle and interventricular septum are much lower than in the control. This tendency is observed until the 21st day, and on the 45th day all thickness indicators were significantly higher in experimental animals. Obtained results can be related with changes in the ratio of muscle and connective tissues by reducing of the first and increasing of the second. Wall’s thickening in experimental animals on the 45th day can be considered as a development of hypertrophic cardiomyopathy, which is one of the manifestations of UCTD in the heart.Conclusions. Intrauterine antenatal administration of the antigen may cause a disturbance in the formation of the connective tissue of the heart, which in the future may lead to decreasing of the adaptive capacity of the myocardium.
ВИКОРИСТАННЯ МЕТОДУ СКІНЧЕННИХ ЕЛЕМЕНТІВ ДЛЯ ЛІКУВАННІ АНГУЛЯРНИХ ПЕРЕЛОМІВ НИЖНЬОЇ ЩЕЛЕПИ
Authors: Hudymenko O. O. , Kuzenko Ye. V. , Demianenko M. M. , Skydanenko M. S.
Published: September 2018

This research presents the technique of numerical calculations of mandible fractures, taking into account morphometric parameters. The received stress-deformed state of the mandible fragments, fastening plate and screws allows us to estimate the relative degree of displacement of the fragments and to evaluate their state after the action of chewing loads of phase 4.The aim of the study – to analyze the behavior of the mandible fragments after fixing the angular mandible fracture with plates of different configurations using modern software complexes that implement the finite element method.Materials and Methods. The behavior mandible fragments after fixing the plates of different configurations was the computer simulation in the ANSYS Workbrench software, namely, its module Transient Structural, which implements the method of finite elements.Results and Discussion. After numerical calculations, it has been discovered that the use of computer technologies in maxillofacial surgery provides a more accurate picture of the treatment results, interaction and relative movement between parts of the system of "mandible fracture – plate – screws", which makes it possible to improve the treatment plan.Conclusions. The use modern software complexes of automated geometric modeling allows us tocreate high-precision models o biomechanical systems based on CT data followed by finite-element sampling ad a numerical experiment in engineering analysis system.
ОСОБЛИВОСТІ ВНУТРІШНЬОЇ БУДОВИ ЯЄЧНИКІВ ПОТОМСТВА ЩУРІВ ПІСЛЯ ВВЕДЕННЯ ПРОГЕСТЕРОНУ ПІД ЧАС ВАГІТНОСТІ
Authors: Hryhorieva O. A. , Kovalchuk K. S.
Published: September 2018

In obstetric and gynecological practice for miscarriage treatment the hormone progesterone is widely used.The aim of the study – to learn the correlation of ovarian structures of rats (follicles, connective tissue, blood vessels and corpus luteum) after the administration of progesterone during pregnancy.Materials and Methods. The ovaries of 48 female Wistar rats were investigated on the 45th, 60th and 90th days of life, and they were divided into 3 groups: intact, experimental (the oily solution of progesterone in a dosage 0.33 ml was administered intramuscularly to the female rats from the 15th to the 18th day of pregnancy), and the control group, which was injected with a physiological solution of sodium chloride in an equivalent dosage. The ovaries were fixed in 10 % neutral formalin, serial paraffin cross sections were stained with hematoxylin and eosin.Results and Discussion. From the 45th to the 90th day in the ovaries of experimental animals the connective tissue volume increase and the relative area occupied by the follicles decrease were observed comparing to the control group of animals. The relative area occupied by corpus luteum was significantly greater in the offspring of animals exposed to progesterone during pregnancy than in control animals. As for the blood vessels, there was a decrease in the relative area of vessels in the ovaries of experimental animals during the entire period of observation.Conclusions. In the experimental group of animals we observed the connective tissue and corpus luteum volume increase, but relative area occupied by follicles and blood vessels decreases during the entire observation period.
ЗАСТОСУВАННЯ КВІНАПРИЛУ ТА L-АРГІНІНУ З МЕТОЮ КОРЕКЦІЇ ЕНДОТЕЛІАЛЬНОЇ ДИСФУНКЦІЇ У ПАЦІЄНТІВ ІЗ АНКІЛОЗИВНИМ СПОНДИЛОАРТРИТОМ ТА В ПОЄДНАННІ З ГІПЕРТОНІЧНОЮ ХВОРОБОЮ
Authors: Smiian S. I. , Koshak B. O. , Slaba U. S.
Published: September 2018

Mortality rate among patients with AS is 2 times higher the population level. It is caused by cardiovascular disease. Now it is clear that the presence of chronic systemic inflammation is an important predictor of cardiovascular (CV) disease due to the development of endothelial dysfunction (ED).The aim of the study – to evaluate the efficacy of correction of ED in patients with AS and arterial hypertension with the use of quinapril and L-arginine aspartate.Materials and Methods. A total of 110 patients with AS were examined with evaluation endothelium-depended vasodilation (EDVD) in response to reactive hyperemia, were chosen patients with EDVD <10 % (n=79), and were divided into 4 groups. Group I included 17 people who received standard therapy. Patients from the group II (n=20) received intravenous infusion of the solution of L-Arginine. Group III included patients with concomitant hypertension and they received quinapril (n=19). Group IV (n=23) consist of patients with hypertension, but their treatment was combination of L-arginine with quinapril.Results and Discussion. It was found that in the group II there was a significant improvement in the endothelium’s function (EDVD (23.2±2.4) % (p=0.0023), and its normalization were in 7 patients. In patients of the third group, who received only quinapril were not found normalization of EDVD in any of the patients. In last group (IV) 7 patients showed normalization of the endothelium, 10 improvements compared with baseline levels, and 6 no changes were observed.Conclusions. L-arginine in the complex therapy of patients with AC can significantly reduce the manifestations of ED in patients without concomitant hypertension. Combined use of quinapril in combination with L-arginine demonstrated improvement of endothelial function and control of blood pressure in patients with hypertension.
ХАРАКТЕРИСТИКА РЕАКТИВНИХ ЗМІН СЛИЗОВОЇ ОБОЛОНКИ ЯСЕН ЗА УМОВ РІЗНИХ ВИДІВ ОДОНТОПРЕПАРУВАННЯ ПІД МЕТАЛОКЕРАМІЧНІ КОНСТРУКЦІЇ
Authors: Radchuk V. B. , Hasiuk N. V.
Published: September 2018

The issue of rehabilitation of patients with defects in hard tissues of teeth and dentition is one of the urgent problems of practical dentistry, since 65 % of the population of our country aged 35–45 years needs dental prosthetics. The traditional methods used to replace dentition defects do not always fully correspond to the aesthetic and functional requirements of patients. The aim of the study – to analyze the literature sources with the characteristic of reactive changes in the mucous membrane of the gum under conditions of various types of odontopreparation for cermet structures. In connection with the introduction of a large number of new materials into practice and the widespread prevalence of a burdensome anamnesis among the population, the issues of their biological tolerance and prevention of possible complications are especially important. The full preservation of periodontal functions after orthopedic treatment is one of the defining signs of the quality of the provided dental care. In addition to the tooth tissues, a significant influence with direct odontopreparation and prosthetics with non-removable orthopedic structures undergoes a tooth-gingival sulcus, is considered as a complex system where factors of the external and internal environment interact. Morphological integrity and functional properties of the dento-epithelial compound undergo constant tests during chewing food. Unlike multilayer flat gingival epithelium, the connective epithelium does not undergo keratinization, but due to its high mitotic activity it quickly regenerates after various injuries. With the introduction into practice of orthopedic dentistry of cast-in-one ceramic coated crowns and bridges, problems arose, the key moments of which are inflammation in the gingival margin of the supporting teeth, gum retraction, thermal injury of the pulp, periodontal overload and morpho-functional changes in the periapical tissues. Any manipulations with marginal gums during prosthetics should be carried out with the utmost care and consideration of the characteristics of the marginal gingival to avoid unpredictable periodontal reactions. The probability of a trauma of the tooth-gingival attachment increases with an irrational choice of the retraction method for various biotypes of the gums. Therefore, before the prosthetics, it is necessary to obtain data on the biotype of the gum, and additionally measure the depth of the gingival groove in order to determine its individual size, which determines the choice of the retraction method aimed at preventing gum injuries in orthopedic treatment.
ІМУНОЛОГІЧНІ АСПЕКТИ ГЕНЕРАЛІЗОВАНОГО ПАРОДОНТИТУ (ОГЛЯД ЛІТЕРАТУРИ)
Authors: Saveleva N. M.
Published: September 2018

The article presents the results of an analytical review of literature data in the field of assessing the state of immunological indicators in patients with generalized periodontitis. These data indicate a close relationship between the state of the human immune system and the development of generalized periodontitis against the background of concomitant somatic diseases. The influence of periodontopathogenic microorganisms on the immune response of a macroorganism is described. Data on the state of local and systemic immunity of patients with generalized periodontitis, abnormalities in antibody formation and the functioning of cellular defense mechanisms, activity and content of phagocytic cells, T-lymphocytes, natural killers, imbalance in the cytokine system in the gums and peripheral blood are presented. A number of authors note a significant role in the development of generalized periodontitis secondary immunodeficiency, allergic reactions and autoimmune processes, the general state of the adaptive mechanisms of the body. Disclosure or deepening of knowledge about the pathogenesis of generalized periodontitis will allow to construct optimal adequate therapy and offer effective prevention of dental disease.
ОЖИРІННЯ ЯК ПЕРЕДУМОВА МЕТАБОЛІЧНОГО СИНДРОМУ (ОГЛЯД ЛІТЕРАТУРИ)
Authors: Korylchuk N. I.
Published: September 2018

Currently, in most countries of the world there is a significant increase in mortality and morbidity of the population. The main reason for this trend is a sharp increase in non-communicable diseases. Ineffective diet, low physical activity against an unhealthy lifestyle and triggers non-communicable diseases. The article analyzes literary data on the prevalence, progression and consequences of overweight and obesity as a precondition for metabolic syndrome and one of the non-infectious diseases.The aim of the study – to show the importance of overweight and obesity as a precondition for MS.Materials and Methods. The review and analysis of scientific and medical literature data is carried out.Results and Discussion. It is obesity that is considered to be a link between various diseases that fall within the competence of cardiologists, endocrinologists, rheumatologists, nephrologists, gastroenterologists, obstetrician-gynecologists, surgeons and other specialists. Scientists consider obesity as a complex problem that determines the health status of the population and predictors of the development of complications. A large number of papers are devoted to the study of the effects of overweight and obesity on type 2 diabetes, arterial hypertension, cardiovascular complications, joint problems, diseases of the gastrointestinal tract, infertility, erectile dysfunction and other diseases. All of these diseases are a heavy burden not only on the patient, his family, and society as a whole. The epidemiological phenomenon of obesity has an important clinical aspect, since obesity greatly increases the morbidity and mortality of the population throughout the planet. Therefore, obesity is not only a medical but also a social, economic problem of the modern society of all countries. In practice, the physician often states overweight and obesity, without paying due attention to studying the problem, identifying its origin, seeking motivation for treatment and the very ways of treatment.Conclusions. Analysis of literature sources proves the relevance of in-depth study of a patient with overweight and obesity, not only in the aspect of clinical and laboratory examinations, but also psychological and social.
ПРЕДИКТОРИ ЗРОСТАННЯ РИЗИКУ СМЕРТІ ВІД УСІХ ПРИЧИН У ПАЦІЄНТІВ ІЗ ПОСТІЙНОЮ ФОРМОЮ ФІБРИЛЯЦІЇ ПЕРЕДСЕРДЬ НЕКЛАПАННОЇ ЕТІОЛОГІЇ
Authors: Romaniuk P. B.
Published: September 2018

Atrial fibrillation (AF) is one of the most common arrhythmias in the heart, and it is a potent risk factor for the development of cardiovascular disease (CVD) and death from all causes.The aim of the study – to identify predictors of the risk of death from all causes in patients with a persistent form of atrial fibrillation (PFTF) of non-valvular etiology.Materials and Methods. We performed a retrospective analysis of 146 histories of diseases of patients with non-valvular PA F with inpatient treatment, 16 patients died at the time of the study, which were subject to further analysis. For heart rate controll, the therapy of BB (bisoprolol and carvedilol) was performed. The endpoint of the study was death from all causes. An assessment of heart rate control on ECG data and echocardiographic parameters were performed at the time of discharge.Results and Discussion. In the group of patients undergoing analysis, strict heart rate control was prevalent. There was an increase in the size of both atriums, the volume of LV , its moderate hypertrophy, moderate regurgitation on the mitral and tricuspidal valve according to the echocardiography data. At the time of discharge, the dosage for heart rate controll was: bisoprolol – (5.6±2) mg, carvedilol – (20±2.3) mg, digoxin – (0.19±0.07) mg. Then we determined the predictors risk increasing of death from all causes. Onefactor regression analysis revealed that the risk of death from all causes among patients with PA F significantly increased with a history of COPD in patient anamnesis (p = 0.01), as well as increase in the NYHA functional class of HF on the scale for each unit (p = 0.046). In multivariate regression analysis, where indicators were selected using stepwise method, the risk of death from all causes in patients with PA F in the presence of COPD in patient anamnesis increased significantly when standardized by other risk factors (p=0.01).Conclusions. Independent risk increasing predictors of the death from all causes in patients with PA F non-valvular etiology are the presence of COPD in patient anamnesis and the increasing of NYHA functional class HF. The death risk from all causes in these patients significantly increases with the presence of COPD in patient anamnesis when standardized by other factors. The study complements the existing data on the importance of heart rate controll in patients with PA F and the correctness of the treatment concomitant HF. The obtained results are new and important for revealing the reasons of high mortality of this category of patients and ways of correction of their treatment.
“Gorged with Proof”
Authors: Howard Elizabeth
Published: September 2018

This essay examines the narrated recollections of the spy in Gerard Manley Hopkins’s unfinished poem “A soliloquy of one of the spies left in the wilderness” (1863). Particular attention is paid to the spy’s account of the Israelites’ wilderness wanderings and slavery in Egypt in order to examine Hopkins’s depiction of a will in rebellion against God. After considering the poem’s relationship to Hopkins’s undergraduate years in light of his imminent conversion to Catholicism, the essay investigates the ways in which the soliloquy’s confused chronologies and emendations call attention to the spy’s spiritual disorders. By reading the spy’s internal disorder as a corollary to the social disintegration in Eden that Hopkins identified in Adam and Eve’s rebellion, the essay argues that the soliloquy attributes the speaker’s inner disorientation to his rebellious will set against God. Although the soliloquy appropriates descriptions of the lush Canaanite landscape to describe Egyptian slavery as comfortable, even luxurious, the vestiges of violence repeatedly interrupt the soliloquy’s relentless insistence on Egypt’s “pleasance.” As the soliloquy’s rhetorical maneuvers repeatedly fail to justify the spy’s rebellion, Hopkins explores and displays the impact of spiritual rebellion on the human psyche.
Sequences of Phrase and Feeling in “The Windhover”
Authors: Cotter James Finn
Published: September 2018

Gerard Manley Hopkins distinguished and approved “sequences of feeling and phrase” in his friend Robert Bridges’s sonnets. A close reading of “The Windhover” reveals Hopkins’s own use of these sequences with a remarkable shift between the octave, developed by a series of adverbial and adjectival participial and prepositional phrases, and the sestet which proceeds as a series of declarative-exclamatory statements. The first half of the sonnet follows the kestrel’s flight as it “hovers” (hence its name) into a fixed position either by beating its wings (“hurl”) or by sitting still (“gliding”). This act of hovering is then transferred from the bird “there” to the poet’s own heart “here” by the verb “Buckle,” with its meaning of joining, bending, putting on, and holding back. This shift in action occurs also in place and time, from past to present, outdoors to an indoor chapel where the poet attended Mass each May morning. The action itself incorporates inscape as catching sight of the pattern of the kestrel’s flight in the morning of Christ’s created light and instress as the heart’s response in thought and being to Christ’s uplifting grace in the fire of redemption. “As kingfishers catch fire” reverses the sequences of feeling and phrase in “The Windhover” as it too moves from the physical (“each mortal thing”) to the supernatural as the “just man” becomes an after-Christ.
“By a Grey-Eye’s Heed”
Authors: Klein Ann Marie
Published: September 2018

In “Harry Ploughman,” Gerard Manley Hopkins describes an agrarian laborer in nautical terms to illustrate how work itself becomes a propeller for life’s voyage. The dynamics of sound due to the sonnet’s rhythm, syntax, and structure imitate the atmosphere and movements of both farmer and ship. By echoing images from “The Wreck of the Deutschland,” Hopkins points to the crucial roles of conscience and grace for guiding action, but not only toward material results. More importantly, they direct the worker toward selfless integrity and conviction, toward greater fullness of being. Hopkins’s polysemous portrayal alludes to the expertise needed for navigating challenges on land, at sea, and in verse. Hopkins’s mastery, like that of all workers who proceed with intensity in response to divine promptings or “stress,” serves as a vehicle for conducting souls to their eternal harbor. The sonnet’s maritime associations, as well as the multivalence of its eye, breath, and child images resonate in Hopkins’s spiritual writings and thereby highlight the vocational aspect of human labor.
“Modest but Well-Deserved Claims”: The Friendship of Samuel Fox and Joseph Bosworth and the Study of Anglo-Saxon in the Nineteenth Century
Authors: Thomas Daniel
Published: September 2018

Joseph Bosworth’s copy of Samuel Fox’s 1835 edition ofThe Metres of Boethius, presented to him by the editor, contains (pasted to the covers) a fragmentary record of the correspondence between the two men which must have extended from 1833 until Fox’s death in 1870. Partial and short as it is, this record of the two men’s correspondence, read in the context of other contemporary documents, gives an interesting (and sometimes amusing) insight into the practice of Anglo-Saxon scholarship in the period. This article will present the letters in this context, and examine the lasting friendship and collaboration of Fox and Bosworth against a backdrop of controversy, religious dispute, and patriotic fervour. In so doing, this article will also consider the legacy of Samuel Fox, a scholar now routinely marginalized in histories of the discipline, but who was held in high regard by at least some of his contemporaries.
An Old English Love Poem, a Beowulf Summary and a Recommendation Letter from Eduard Sievers: G. J. P. J. Bolland (1854–1922) as an Aspiring Old Germanicist
Authors: Porck Thijs
Published: September 2018

This article calls attention to documents relating to the early academic life of G. J. P. J. Bolland (1854–1922). During the late 1870s and early 1880s, Bolland was enthralled by the study of Old Germanic languages and Old English in particular. His endeavours soon caught the eye of Pieter Jacob Cosijn (1840–1899), Professor of Germanic Philology and Anglo-Saxon at Leiden University, who helped the Groningen-born student to further his studies. During his stays in London and Jena, Bolland communicated with prominent scholars, including Henry Sweet, Richard Morris and Eduard Sievers. Bolland’s annotated books, hand-written notes and scholarly correspondence provide a unique insight into academic life and student-professor relationships during the late nineteenth century. In addition, Bolland produced an Old English love poem and aBeowulfsummary that are published here for the first time.
In Praise of Outsourcing
Authors: Levy Neil
Published: September 2018

What explains the context sensitivity of some (apparent) beliefs? Why, for example, do religious beliefs appear to control behaviour in some contexts but not others? Cases like this are heterogeneous, and we may require a matching heterogeneity of explanations, ranging over their contents, the attitudes of agents and features of the environment. In this paper, I put forward a hypothesis of the last kind. I argue that some beliefs (religious and non-religious) are coupled to cues, which either trigger an internal representation or even partially constitute the beliefs. I show that such coupling will give rise to the context-sensitivity, without entailing that religious believers take a different attitude to belief content.
William James and Embodied Religious Belief
Authors: Tan Tobias
Published: September 2018

Scholars have recently identified resemblances between pragmatist thought and contemporary trends in cognitive science in the area of ‘embodied cognition’ or ‘4E cognition.’ In this article I explore these resemblances in the account of religious belief provided by the classical pragmatist philosopher William James. Although James’s psychology does not always parallel the commitments of embodied cognition, his insights concerning the role of emotion and socio-cultural context in shaping religious belief, as well as the action-oriented nature of such beliefs, resonate with embodied and embedded accounts of religious belief. James’s insights are readily extended in light of contemporary embodied cognition research to highlight the interdependency between religious belief of individuals and the cognitive scaffolding provided by embodied religious practices.
New and interesting species of ptyctimous mites (Acari, Oribatida) from Nepal
Authors: NIEDBAŁA WOJCIECH , ERMILOV SERGEY G.
Published: September 2018

The present study is based on ptyctimous oribatid mite material (Acari, Oribatida) collected in Nepal in 1980 and 1995. A list of identified taxa, including 18 species from 12 genera and five families, is provided; of these, Apoplophora pantotrema, Euphthiracarus carinatus, Phthiracarus boresetosus and Ph. setosus are recorded for the first time in the Nepalese fauna. Two new species of the genus Plonaphacarus (Steganacaridae) are described: P. diutissimus Niedbała sp. nov. differs from P. machadoi (Balogh, 1958), P. tanzicus (Mahunka, 1993), P. ngongi Niedbała, 2001 and P. styphelos Niedbała, 2001by the length of lamellar and notogastral setae, number of notogastral lyrifissures, and the morphology of setae d on leg femora I; P. pugionis Niedbała sp. nov. differs from P. kaluzi Niedbała, 2013 by the morphology of sensilli, arrangement of notogastral setae c1–3, length of subcapitular setae h, morphology of adanal setae ad2, and the localization of setae d on leg femora, and from H. similis Niedbała, 2000 by the shape of sensilli, rostral and notogastral setae and arrangement of notogastral setae c1-3. The supplementary description of Euphthiracarus carinatus Liu, Wu & Chen, 2011 (Euphthiracaridae) is given.