bluuebunny/crossref_metadata_2025 huggingface dataset:
The Origin of the Ryazan-Oka Cruciform Fibulae and the Genesis of the Local Military Elite
Authors: Semenov Alexander Sergueevich , Gavrilov Aleksandr Petrovich , Kulakov Vladimir Ivanovich
Published: January 2023

The study of the Ryazan-Oka culture has been going on for more than 100 years. Its main area is the Middle Pooch, with a significant tendency to dominate in the Volga-Oka interfluve from the first centuries of our era until the 60s of the VII century AD. With some degree of hypotheticism, the Ryazan-Oka center, along with the Old Ladoga, can be considered as one of the points of laying the foundations of the Old Russian statehood. The author's team sets itself the task of clarifying certain issues of the formation of the Ryazan-Oka elite on the basis of the latest DNA data and studying the most important cultural artifacts - the cross-shaped fibulae of elite warriors.The scientific novelty of the research is the combination of the study of objects of material culture with the latest DNA data. The study showed that the genesis of the most important attribute of the Ryazan-Oka elite - cross-shaped fibulae - can be associated with the shores of the Western Baltic and the North Sea (including Scandinavia). DNA data indicate the possible origin of a part of the military elite from the shores of the Baltic and the Northwestern part of the Eastern European Plain. Thus, it is quite legitimate to raise the question of migrations (of population and material culture) to the Ryazan-Oka area from the northwest. The latter could have an East Germanic, Baltic, Early Slavic, Baltic-Finnish linguistic affiliation.
The Main Trends in the Formation of the Soviet Federal Socio-Territorial Space (1917 – 1922)
Authors: Sosenkov Fedor Sergeevich
Published: January 2023

The subject of the study is the process of formation of the Soviet federal socio-territorial space in the period 1917 – 1922, which includes the design of the state borders of Soviet Russia, the definition of the principles of the Soviet Federation (internationalism, the right of nations to self-determination), the regions composition of the RSFSR, the order of distribution of rigions and powers between the center and the regions, the scope of such powers and subjects of reference. The purpose of this study was to study the trends in the formation of the Soviet Federation in the diversity of its regions, the influence of these trends on outsiders of the next historical level of the Soviet Federation – the Union of Soviet Socialist Republics. To achieve this goal, a set of universal (dialectics), general scientific (analysis, synthesis, deduction, induction, structural-system method), private scientific methods (historical method), special methods (formal legal, comparative legal) were used. The novelty of the research lies in the fact that the author highlights the following trends in the first experiments of building a Soviet federal state: 1) the experimental nature of the construction of the Soviet federation in the absence of appropriate political and legal experience; 2) the ideocratic nature of the Soviet federal state, based on internationalism and the right of nations to self-determination; 3) the national-territorial nature with obvious asymmetry in favor of national subjects; 4) the initial non-determination of the borders of the Soviet federation; 5) the indefinite subject composition of the federation, constantly changing, both qualitatively and quantitatively; 6) the situational and individual nature of the distribution of subjects of competence and powers between the center and the regions. A special contribution of the author to the research of the topic is the introduction into scientific circulation of archival documents from the funds of the State Archive of the Russian Federation and the State Archive of Socio-Political History.
Effect of Yoga Intervention on Inflammatory Biomarkers among Women with Breast Cancer – A Systematic Review
Authors: Kaje Kaini Cecilia , Dsilva Fatima , Sanal T. S. , Latha T. , Kumar Shishir , D’Souza Caren
Published: January 2023

Background:

Inflammatory markers play a substantial role in the prognosis of breast cancer (BC). Studies have been conducted, evaluating the effect of yoga intervention (YI) on inflammatory biomarkers among BC cases. This systematic review consolidates the outcome of YI in the cancer microenvironment.

Objective:

The objective of the study was to evaluate the effect of YI in the cancer microenvironment among BC women.

Materials and Methods:

This review was conducted from May 2021 to December 2021. The inclusion criteria were experimental studies on adult BC cases with isolated YI. Studies conducted among paediatrics, case reports and case series were excluded from the study. Medline (PubMed), Medline (Ovid), Web of Science (WOS), Scopus, CINAHL and Cochrane Central databases were searched. The data were restricted from January 2000 to December 2021 with studies published in English. ‘The Cochrane risk of bias assessment tool’ was mobilised to evaluate the quality of the included studies.

Results:

A total of nine studies met the inclusion criteria and comprised a sample size of 905 BC cases with a mean age of 50.26±8.27 years. Three studies evaluated tumour necrosis factor-alpha (TNF-α) and INTERLEUKIN (IL)-6, where two studies on TNF-α and one on IL-6 favoured the YI group. A study investigated soluble TNF receptor II (TNF-RII) and another on IL-1beta (IL-1β) has shown improved levels post-YI. A downward trend of cortisol levels was noted in four out of five studies. Two studies that examined the C-reactive protein and a study on IL-8 did not show any difference between the YI and the control groups.

Conclusion:

This review’s findings showed the downregulation of cortisol, markers of inflammation; TNF-α, IL-6, TNF-RII and IL-1β immediately to post-YI. Heterogeneities in terms of YIs, number of days of practice, duration and training received and the grade of BC cases are the concern of this review. However, YI can be considered a supportive therapy for BC.
Evolution Magmatism of Nagasari Volcano Dieng, Central Java, Indonesia
Authors: Yudiantoro Dwi Fitri , Haty Intan Paramita , Pambudi Setia , Magdalena Elisabet , Putri Armala , I. Takashima  , M. Abdurrachman
Published: January 2023

Nagasari Volcano, part of the Dieng volcanic complex, is one of the unique volcanoes in Central Java. Around this volcano grow eruption craters, volcanic cones, and pyroclastic flow ridges. There were several 14 eruption centers around Mount Nagasari, so it is necessary to know the development of magmatism evolution. The aims of the research to determine the evolutionary development of magmatism. The methodology used is geological mapping and petrographic analysis. The observations of rocks found in the study area include andesite lava, lapilli-tuff, fallen pyroclastic breccias, and flow pyroclastic breccias. Meanwhile, geological mapping and petrographic observations of volcanic rock samples show that the evolution of magmatism in the study area from the oldest to the youngest is basaltic magma that formed Prau Volcano in the pre-caldera period. On the other hand, magmatism in the post-caldera I period was of the type of pyroxene andesite forming the Gembol to Jimat Volcano group. In contrast, in the post-caldera II period, the hornblende-biotite andesite group formed the Dieng Kulon to Kendil group.
Identification of Potential Geotourism Destination in the River Subayang areas of Kampar, Riau, Indonesia
Authors: Martania Dwita , Tanjung Mira Hafizhah , Suryadi Adi
Published: January 2023

The readiness of an area to be able to develop tourism potential as geotourism is seen from various aspects, including the existing geological heritage, as well as the enthusiasm of the local community which is the main focus in creating good geotourism, while the government acts as the main mover. In Kampar Regency, Riau Province, to be precise in the Sushadow River area, the Rimbang Balling area located in the Kampar Kiri Hulu sub-district, there are natural attractions that the Subayang river passes through, in addition to the river being so clear, upstream we can find a stone wall waterfall, possibly having a waterfall. This paper, shows the potential of geotourism froum various aspects of geomorphology and community life, such as economic, social, cultural and infrastructure and discusses the role of society and sectors as tourism actors in subayang river using the RAP-fish method. Geotourism studies can be drawn from various integrations of existing theories, conceptual analyzes and practices of nature-based tourism and closer collaboration with relevant social sciences so that they can play a role in the promotion of tourism among the public and professionals.
Characteristics and Potential of Placer Gold Deposit in Lakan Bilem Block, West Kutai District, East Kalimantan, Indonesia
Authors: Idrus Arifudin , Raharjanti Ni’matul Azizah , Sufriadin
Published: January 2023

Kalimantan is recognized as one of Indonesian islands with huge prospect of minerals particularly gold both primary and secondary deposit styles. However, the publication of the gold resources is still restricted to be described in regional/district scale maps or exploration company internal reports, hence, a detailed study on deposit scale remains limited. This study is aimed to document the characteristics and the estimation of potential or resources of the secondary (placer) gold deposit in Lakan Bilem block, West Kutai district, East Kalimantan province, Indonesia. The study was done by field observation followed by microscopic analysis and simple resources estimation of the gold. Gold in the study area occur in the semi-consolidated paleo alluvial deposit as trace mineral. The gold morphologies show platy to angular form with coarse surface which indicates the process of gold deposition is predominantly controlled by hydrodynamic transportation at a relatively moderate regime. Estimation of the indicated resources of gold results a total of 4.96 tonnes of gold potentially occurred in the study area. Exploration drilling with 100 spacing grid is suggested to delineate lateral and vertical distribution of the gold deposit. The drilling also will upgrade confidence level of the resources from indicated to measured resources.
MANAGEMENT OF REGULATORY AND LEGAL PROVISION OF PROFESSIONAL DEVELOPMENT OF PEDAGOGICAL WORKERS IN UKRAINE
Authors:   Communal Institution of Higher Education “Dnipro Academy of Continuing Education” of Dnipropetrovsk Regional Council, Totochenko Tetiana , Rybkina Svitlana ,   Communal Institution of Higher Education “Dnipro Academy of Continuing Education” of Dnipropetrovsk Regional Council
Published: January 2023

Reforming the education system of Ukraine in accordance with the concept of high-quality, modern and affordable general secondary education "New Ukrainian School", the needs of society to provide quality educational services impose certain requirements on the professional level of teaching staff. Pedagogical workers are the driving force of the reform, therefore special attention is paid to the system of professional development, which is a component of adult education. The system of professional development should contribute to the continuous professional and personal development of teachers, the formation of their own trajectory of professional development, be advanced. The article analyzes the normative legal acts regulating the professional development of pedagogical workers in Ukraine. According to the Law of Ukraine "On Education", teaching staff are obliged to constantly raise their own professional and general cultural level and pedagogical skills. Continuous professional development is one of the labour functions of a teacher, determined by professional standards. In addition, certification of teaching staff is impossible without advanced training. The approval of the order of professional development allows to determine the types, forms, volume and periodicity of professional development, the procedure for recognizing the results of professional development, and also gives teachers the opportunity to independently choose the forms of education, educational programs and subjects of professional development. Payment for professional development of employees is guaranteed by the state. Municipal institutions of postgraduate education, financed from the relevant budgets, meet the needs of the regions to improve the skills of pedagogical personnel. In addition, the legislation provides for the possibility of attracting other sources of financing, such as the state budget, own income of educational institutions. Significant changes in legislation that have occurred in recent years have created favourable conditions for continuous professional and personal development of pedagogical personnel in Ukraine. At the same time, the analysis of the mechanism of planning advanced training by educational institutions showed the need to make changes to the Procedure for advanced training in order to clarify it, as well as the need to update the provision on the certification of teaching staff.
LEGISLATIVE REGULATION OF ACCESS TO DOCUMENTS OF THE NATIONAL ARCHIVAL FUND AS A COMPONENT OF THE STATE POLICY OF NATIONAL MEMORY IN UKRAINE
Authors:   Taras Shevchenko Kyiv National University, Vlasenko Svitlana
Published: January 2023

The purpose of the study is to analyze the legislative framework for regulating access to documents of the National Archival Fund (NAF) as a component of the state policy of national memory in Ukraine. Research methodology: when preparing the article, general scientific methods were used in combination with interdisciplinary and special methods; a significant place given to historical, systematic, structural-functional, and logical approaches to scientific research. The main results of the research: the legislative framework in the archival industry of Ukraine related to the regulation of access to NAF documents was analyzed; the process of forming the legislative framework was reproduced and the evolution of the control of access to archival documents was traced, taking into account the main principles of the state policy of national memory; problematic issues and ways to solve them are defined; the initiatives and actions of the Main Archival Department under the Cabinet of Ministers of Ukraine / the State Committee of Archives of Ukraine / the State Archival Service of Ukraine, as the central body of the executive power, in the law-making process were monitored; the participation of civil society institutions in the law-making process is clarified; it was concluded that the legislative framework complies with the principles of transparency and accessibility, which allows for free access to NAF documents, taking into account the rights of citizens and the interests of the state. Prospects for further research include an analysis of the entire regulatory framework for regulating access to NAF documents, as well as a comparative analysis of the regulatory framework in Ukraine and other countries. Factual material, main provisions, and conclusions can be used when writing general papers, methodological developments, normative and special courses on public administration issues, archival studies, and the practical activities of state archival institutions of Ukraine.
THE SOCIAL AND CULTURAL POLICY OF THE STATE AS A CONDITION FOR THE FUNCTIONING OF SOCIAL AND CULTURAL ACTIVITIES
Authors:   Kharkiv State Academy of Culture, Pshynka Hanna
Published: January 2023

The article analyzes the socio-cultural policy of the state and the functioning of socio-cultural activities. It is proved that the development of the foundations and gradual implementation of the state socio-cultural policy is a necessary condition for successful progress along the path of cultural education of the country's population, a guarantee of comprehensive development of members of a democratic society, building a new civil society based on world and national cultural values. The main goals and priorities of modern state sociocultural policy are defined: comprehensive development of the system of sociocultural value orientations of a person and society; assistance to the population in the formation of forms of state self-determination and self-expression adequate to new conditions, social and economic and socio-cultural identity, social and individual consciousness; comprehensive development of the spiritual and value component in all manifestations of socio-cultural interests and needs of people, etc. It is found out that the subject and object of socio-cultural policy is society itself, which is only corrected by state authorities, and it acts as a socio-cultural system that self-organizes and develops continuously adapting to changing conditions of existence. The main functions of socio-cultural activity are defined: educational; cognition; practical and transformative; communication; educational; functions related to animation activities, recreation and entertainment, recreational; public relations; diagnostic; prognostic; project, etc. The main principles of socio-cultural activity are clarified among them: the principle of socially valuable target orientation; the principle of integrity in the approach to all processes of interaction of various types, forms, methods, means of activity; the principle of harmony in socio-cultural activities of the development of amateur foundations in the life of society; the principle of esthetic of the leading role of socio-cultural activities in the development of essential forces and talents; the principle of combining admiration and involvement in the novelty of the business of taking into account individual and age characteristics; the principles of consistency, systematicity, accessibility.
The expression of microRNA and genes as candidates for the gastric cancer metastasis markers
Authors: Ф.М. Кипкеева, , Т.А. Музаффарова, , М.П. Никулин, , Д.Ж. Мансорунов, , П.В. Апанович, , О.А. Малихова, , А.В. Карпухин,
Published: January 2023

Рак желудка (РЖ) является одной из существенных причин смертности от онкологических заболеваний. Неблагоприятный прогноз при РЖ в значительной мере связан с метастазированием опухоли. Экспрессия генов и микроРНК может являться источником биомаркеров, сигнализирующих о повышенном риске метастазирования опухоли. Выявление генов, ассоциированных с метастазированием опухоли, и создание прогностической панели микроРНК и генов, является весьма актуальным. Нами исследована экспрессия микроРНК miR-34a и miR -335 и генов FGFR2, VEGFR1 и NRP1 при диссеминированном РЖ в сравнении с не метастазирующими опухолями РЖ. Охарактеризована ассоциация с развитием отдаленного метастазирования, указывающая на их качество как кандидатов в маркеры. Сформированы панели, включающая гены и микроРНК - кандидаты в маркеры прогноза. Проведенный сравнительный анализ панелей позволил выбрать в качестве наиболее эффективной панель, включающую miR335/ VEGFR1 /FGFR2, которая демонстрирует наилучшие показатели как кандидат прогноза метастазирования, особенно по значению отношения шансов ОR = 143 и RR = 7,1.

Gastric cancer (GC) is one of the significant causes of mortality from cancer. An unfavorable forecast for GC is largely associated with tumor metastasis. Expression of genes and microRNAs can be a source of biomarkers that signal the increased risk of tumor metastasis. The detection of genes associated with tumor metastasis, and the creation of a candidate prognostic panel of microRNAs and genes is very relevant. We investigated the expression of MIR-34A and MIR -335 microRNA and FGFR2, VEGFR1 and NRP1 genes with disseminated gastric cancer in comparison with non-metastatic GC tumors. Association is characterized with the development of remote metastasis, indicating their quality as candidates for markers. Panels are formed, including genes, and microRNAs - candidates for prognostic markers. A comparative analysis of the panels allowed to be characterized as the most efficient panel, including MIR335/VEGFR1/FGFR2, which demonstrates the best indicators as a candidate for the metastasis prediction panel, especially the value of the ratio of the chance of OR = 143 and RR = 7.1.
Metachronous Cancer of Carcinosarcoma of the Uterus with Adenocarcinoma of Ovary: A Rare Case Report
Authors:   Clinical Oncologist, National Oncology Center, Aden, Yemen, Noman Saeed
Published: January 2023

Carcinosarcoma of the uterus (also known as malignant mixed Mullerian tumor, MMMT). Uterine carcinosarcoma is a rare, highly aggressive, rapidly progressing neoplasm associated with a poor prognosis that has not significantly improved in the past 30 years despite advances in imaging and adjuvant therapies. Our case is a Metachronous cancer where diagnosed two cancers at different time and she is on etoposide orally daily, She will evaluation after three months to see the response.
Sinonasal Angiomyolipoma at Vidian’s Nerve: Case Report with Literature Review
Authors:   Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA, F Zahra Aly , BC Lobo ,   Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Published: January 2023

A 76-year-old male presented to the Otolaryngology clinic for an incidental right nasopharyngeal mass. The patient has a history of type 2 diabetes, obstructive sleep apnea treated with continuous positive airway pressure, and polio. Past otolaryngologic surgical history included tonsillectomy. Four months prior, the patient was evaluated for scalp lesions that were diagnosed as sebaceous carcinomas. Resultant screening magnetic resonance imaging (MRI) of the brain revealed an enhancing 2.1 x 1.7 cm mass extending from the anterior choana into the nasopharynx (Figure 1).
Bilateral Renal Metastasis Revealing an Adenocarcinoma of the Lung
Authors:   Department of Radiology, National Institute of Oncology, Mohammed V University, Rabat, Morocco, H Adil , H Jerguigue ,   Department of Radiology, National Institute of Oncology, Mohammed V University, Rabat, Morocco, R Latib ,   Department of Radiology, National Institute of Oncology, Mohammed V University, Rabat, Morocco, Y Omor ,   Department of Radiology, National Institute of Oncology, Mohammed V University, Rabat, Morocco
Published: January 2023

Lung cancer represents the first cause of death by cancer in the world, and adenocarcinoma is the most commonly histological subtype. Extra-thoracic metastasis of lung cancer is mostly encountered in the brain, the bone, the liver, as well as the adrenal gland. Hence, renal metastasis from lung cancer is extremely rare. They are usually asymptomatic; however, they may present with pain and hematuria. Renal metastasis usually presents as small, multiple, and bilateral, wedge-shaped masses, with endogenous growth. Although, some case reports documented unilateral, well circumscribed, exogenous mass simulating primary renal carcinoma. Thus, the definitive diagnosis requires histopathology examination after surgical resection or core needle biopsy.
Acute Coronary Syndrome Combined with Aortic Dissection Type A
Authors:   Cardiothoracic Department Hippocratio General Hospital Athens, Greece, C Simoglou , I Bertus ,   Department of Cardiothoracic Surgery, University of Bristol, School of Medicine, UK
Published: January 2023

We are presenting a case of Stanford Type a aortic dissection in a 58 year old male patient with history hypertension. He arrived at Emergency Department (ED) with diagnosis acute coronary syndrome a few hours after he developed sudden, severe worsening of his epigastric pain. Interesting case where the separation starts from the orifice of the right coronary artery, occupies the aortic valve.
Diagnosis of Ventricular Asystole with Complete Transient Atrioventricular Block
Authors:   National Research Oncology Center, Nur-Sultan, Republic of Kazakhstan, A Bilmakhanbetova , T Seisembekov ,   Astana Medical University, Nur-Sultan, Republic of Kazakhstan, T Moldabekov ,   National Research Oncology Center, Nur-Sultan, Republic of Kazakhstan, G Zhakhina ,   National Research Oncology Center, Nur-Sultan, Republic of Kazakhstan, Z Khamitova ,   National Research Oncology Center, Nur-Sultan, Republic of Kazakhstan, G Kulkayeva ,   National Research Oncology Center, Nur-Sultan, Republic of Kazakhstan
Published: January 2023

Holter monitoring is a diagnostic method for patients with suspected arrhythmias. This clinical case describes persistent form of atrial flutter and Ventricular Asystole (VA) with Atrioventricular Block (AVB) diagnosed by Holter monitor. Diagnostics found VA of more than 3.0 seconds, meaning this condition may not always be associated with syncope.
M1- and M2-Polarized Macrophages Modified Inflammatory Environment and Affects Malignant Behaviors of Cancer Stem-like Cells (CSCs) Derived from Human Melanoma Cells A375
Authors:   Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China, Z Chen , Y Pu ,   Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China, K Zhou ,   Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China, R Liu ,   Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China, Y Cen ,   Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China, J Chen ,   Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China
Published: January 2023

Tumors contain a sub-population of cells characterized by self-renewal and expanding capacities which were known as cancer stem-like cells (CSCs). Sphere formation in conditioned serum-free medium supplemented with epidermal growth factor and basic fibroblast growth factor is a well-accepted manner for enriching CSCs from several kinds of tumor cells, including melanoma cells A375. The effects of polarized macrophages on malignant behaviors of melanoma cells were well studied, however, little was known about the effects of inflammatory environment modified by polarized macrophages on melanoma CSCs. In this study, tied to figure out these effects, we firstly stimulated the polarization of M1- and M2-state macrophages and confirmed the successful stimulation via detecting hallmarkers. Then the successful enrichment of A375 CSCs was confirmed by performing self-renewal capacity. Via detecting the malignant behaviors, it is observed that inflammatory environment modified by M1-polarized macrophages inhibited proliferation, blocked cell cycle phases at G1/G0, decreased invasive, tumor formatting abilities and induced cisplatin-sensitivity by promoting apoptosis. Contrarily, M2-conditioned medium desensitized A375 CSCs to cisplatin without affecting other malignant behaviors including proliferation, cell cycle, invasion and tumor formation. Meanwhile, M2- conditioned medium protected stemness of CSCs under oxidative stress. How the modified inflammatory microenvironment affects CSCs was performed by adding macrophage-specific cytokines and the results indicate that M1-polarized and M2-polarized macrophages partially affected CSCs via increased secretion of cytokines, including IL-1β, TNF-α and TGF-β. Taken together, we provide evidence that different macrophage polarization affected malignant behaviors of A375 CSCs partially via secretion of cytokines.
Historical Symbolism and Heritage Value of Bupyeong Armory
Authors:   Institute For Kyeongki Cultural Studies, Park Myung Shik
Published: January 2023

Recently, opinions on demolition and preservation are conflicting with each other over the traces and some of buildings of the Incheon Army Arsenal of Japanese Colonialism. The main reason for this conflict of opinions is that research or investigation on the historical meaning of the Incheon Army Arsenal and its ripple effects, which were created in the Bupyeong area under the Japanese colonialism, has not been dealt with in earnest from a comprehensive perspective. This study reveals the location background and main functions of the Incheon Army Arsenal in the Bupyeong area during the Japanese colonial era, focusing on related data at the time, while exploring the historical meaning of the Incheon Army Arsenal today to identify some of the buildings that made up the Incheon Army Arsenal. We tried to propose a solution to the recent disagreement over preservation and demolition
Investigating Native Metal Ion Binding Sites in Mammalian Histidine-Rich Glycoprotein
Authors: Ackermann Katrin , Khazaipoul Siavash , Wort Joshua , Sobczak Amélie , ElMkami Hassane , Stewart Alan , Bode Bela
Published: January 2023

Mammalian histidine-rich glycoprotein (HRG) is a highly versatile and abundant blood plasma glycoprotein with a diverse range of ligands that is involved in regulating many essential biological processes, including coagulation, cell adhesion and angiogenesis. Despite its biomedical importance, structural information on the multi-domain protein is sparse, not least due to intrinsically disordered regions that elude high-resolution structural characterisation. Binding of divalent metal ions, particularly ZnII, to multiple sites within the HRG protein is of critical functional importance and exerts a regulatory role. However, characterisation of the ZnII binding sites of HRG is a challenge; their number and composition, as well as their affinities and stoichiometries of binding are currently not fully understood. In this study, we explored modern electron paramagnetic resonance (EPR) spectroscopy methods in combination with AlphaFold2 protein structure prediction to assemble a holistic picture of native HRG and its interaction with metal ions. To our best knowledge this is the first time this suite of EPR techniques has been applied to count and characterise endogenous metal ion binding sites in a native mammalian protein of unknown structure.
Influence of the fluorophore mobility on distance measurements by gas phase FRET.
Authors: Metternich Jonas B. , Katzberger Paul , Kamenik Anna S. , Tiwari Prince , Wu Ri , Riniker Sereina , Zenobi Renato
Published: January 2023

Gas-phase Förster resonance energy transfer (FRET) combines the advantages of mass spectrometry and fluorescence spectroscopy for the conformational analysis of mass-selected biomolecules. While this implementation of FRET in the gas phase promises detailed insights for fundamental and applied studies, the gas-phase environment also poses great challenges. For FRET, fluorophore pairs are typically covalently attached to strategic binding sites in the backbone of a biomolecule, using short linkers. The linker further increases the mobility of the dye, contributing to rotational averaging of the relative orientation of the transition dipole moments of donor and acceptor. However, little is known about the fluorophore’s degrees of freedom in the gas phase and how it may be influenced by intramolecular interactions. In this study, we test the influence of a fluorophore’s linker length on the measured FRET efficiencies in the gas phase to probe the mobility of the fluorophore. An increased FRET efficiency was observed with increasing linker length, ranging from 5.3 % for a linker consisting of 2 atoms to 27.7 % for a linker length of 13 atoms. To rationalize this trend, we profiled the conformational landscape of each model system with MD simulations. Employing state-of-the-art enhanced sampling techniques, we captured intramolecular interactions that promote a population shift towards smaller donor-acceptor separation for longer linker lengths and induce a significant increase in their acceptor dipole. The presented methodology is a first step towards the explicit consideration of a fluoruophore’s range of motion in the interpretation of gas-phase FRET experiments.
The Decarboxylation and Protonation Enigma in the H85Q Mutant of Cytochrome P450OleT
Authors: Yadav Shalini , Shaik Sason , Dubey Kshatresh
Published: January 2023

Cytochrome P450OleT (CYP450OleT), a member of CYP450 Peroxygenases, catalyzes unusual decarboxylation activity. Unlike other members of the peroxygenases family, CYP450OleT possesses a Histidine at the 85th position, which was supposed to be the root cause of the decarboxylation activity in CYP450OleT. This work addresses the His85Gln mutant paradox where mutation of HisGln still shows efficient decarboxylation activity in CYP450OleT. The MD simulation of the H85Q mutant of CYP450OleT shows that in the absence of the histidine at 85th position, an Asp239 plays a similar role via a well-organized water channel. Our simulation shows that such a water channel is vital for the optimal substrate positioning needed for the decarboxylation activity and is gated by the Q85-R242 residue pair. Interestingly, the MD simulation of the WT CYP450BSβ shows a closed channel that blocks the access to the Glu236 (analogous residue to Asp239 in CYP450OleT) and, therefore CYP450BSβ shows low decarboxylation activity.
3D Paleoseismology from iOS Lidar and Structure from Motion Photogrammetry: a case study on the Dog Valley fault, California
Authors: Pierce Ian , Koehler Richard
Published: January 2023

Measuring displacements of strike-slip paleoearthquakes from trenching excavations requires detailed 3D trenching excavations. Here a new methodology utilizing an iOS based laser scanner and structure-from-motion is used to reconstruct stratigraphy and trace a displaced fluvial channel sequence across the Dog Valley fault in Northeastern California. The Dog Valley fault is a left-lateral strike slip fault in the northern Walker Lane.  The northern Walker Lane accommodates ~5-7 mm/yr of dextral shear; however, the relative rates of deformation and earthquake history of the fault have not been previously assessed.  Here, we present geomorphic mapping observations and preliminary paleoseismic trenching results from the Dog Valley fault. Lidar data reveal a clear east-northeast striking fault trace that extends about ~25 km from the Prosser Creek drainage west of the Polaris Fault near Highway 89 to the northwest flank of Peavine Mountain. The main trace of the fault appears to project through Stampede dam. Youthful fault scarps are visible along much of the fault, with alternating northwest- and southeast-facing scarps. Clear lateral displacements are largely absent along the fault, however right-stepping fault strands, sidehill benches, linear valleys and ridges, and alternating scarp facing directions are all consistent with left-lateral strike slip displacement. Stratigraphic and structural relations exposed in the Dog Valley fault trench show clear truncations and tilting of bedded fluvial and peat deposits and provide evidence for the occurrence of two Holocene earthquakes: the most recent earthquake postdates ~8 ka, and an earlier earthquake is inferred to have occurred between 8491-8345 cal. ybp.  Based on 3D excavations of a prominent channel margin, the most recent earthquake was associated with ~ 115 cm of left-lateral displacement, corresponding to an M6.7 earthquake.
TEMPORAL VARIATIONS OF NDVI WITH RESPONSES TO CLIMATE CHANGE IN MAYURBHANJ DISTRICT OF ODISHA FROM 2015-2020
Authors: Swain Ajit Kumar , Mohapatra Priyanka , Mishra Jyotiprakash
Published: January 2023

The study aims to calculate the Normalized Difference Vegetation Index (NDVI) in the Mayurbhanj District of Odisha, analyze the temporal changes in the Normalized Difference Vegetation Index (NDVI) of the study area, and examine the effects or impacts of vegetation change on the environment. The Normalized Difference Vegetation Index (NDVI) values of four different seasons in January, April, July, and October for the years 2015,2016,2017,2018, and 2019 were compared to the NDVIs values of January, April, July, and October for the year 2020 respectively. The changes in vegetation pixel areas were calculated using the raster calculation tool. Analyzing the database of these 6 years, it was found that, the highest significant loss was found in July 2016 at 3381.3 ha. and the lowest at 43.2 in October 2018. The loss was maximum in October 2018 at 3683.7 ha. and lowest in July 2017 at 960.3 ha. No change in vegetation category was highest in the year 2017, October of 3855.6 ha. and lowest in the year 2018, July of 1065.6 ha. In the year 2017, July had the highest gain in the vegetation of 3154.5 ha., the maximum whereas the lowest gain in October 2017 was at 1248.3 ha. The significant gain was maximum in the year 2017, April of 1775.7 ha. and a minimum of 3.6 ha. in October 2016. The year 2015 and 2019 had no more effect on vegetation changes whereas the year 2016-2018 was severely affected by a change in vegetation and they have a huge effect on the environment of Mayurbhanj.
OPTIMAL WEATHER ROUTING BASED ON ADAPTIVE BACTERIA FORAGING ALGORITHM FOR VESSEL
Authors: Hung Phan Van , Dang Quang Viet , Dat Le Thanh
Published: January 2023

The economic efficiency, energy efficiency, reduce emission, increasing safety and security play a vital role to develop a sustainable shipping fleet. One of important measures to response these requirment is the optimal weather routing system. Because of the vessel routing is influenced by the quality of meteorological and oceanographic data such as wind, waves, and currents. Therefore, In this study an optimal weather routing model (OWR) considers the meteorological and oceanographic information, ship’s characteristics combined with adaptive Bacterial Foraging Optimization Algorithm will be proposed and applied for ship’ navigation. The simulation results will be presented to show the effectiveness as well as the reliability of this model. The OWR will make it possible for safe navigation, effective operation, energy efficiency and reduce emission from vessel.
OPTIMIZATION OF COMPRESSION IGNITION ENGINE FUELLED WITH COTTON SEED BIODIESEL USING DIGLYME AND INJECTION PRESSURE
Authors: Nagarajan J. , Balasubramanian Dhinesh , Khalife Esmail , Usman Kaisan Muhammad
Published: January 2023

The main research problem from the usage of diesel engine arises from increased fuel prices and emissions releasing from combustion. The objective of the current work relies on finding out a suitable biodiesel blend and improving the diesel engine characteristics by means of additives. The current study discusses about the optimization of the diesel engine characteristics employing cotton seed biodiesel (CSOME) blends. CSOME 20 was found to give the better engine characteristics. Also the engine characteristics were optimized with the addition of diglyme at proportions of 10 and 15% to CSOME20. Along with further optimization was done with varying injection pressure values. It was observed that CSOME DGM 15 reduced the smoke and carbon monoxide emissions with rise in Nitrogen Oxides. BTE was recorded to be highest at 220 bar. Smoke and hydrocarbon were found to be minimum at 220 bar with maximum NOx emissions.
Therapeutic Effect of Integrated Traditional Chinese and Western Medicine on Anal Pruritus After Anorectal Surgery
Authors: Wu Fei-fei , Sha Jingtao
Published: January 2023

Objective: To explore the therapeutic effect of integrated traditional Chinese and western medicine on anal pruritus after anorectal surgery. Methods: Ninety-eight patients with anal pruritus after anorectal surgery in our hospital were selected as the research subjects. They were divided into two groups, the control group (50 cases) and the study group (48 cases), according to the treatment plan. The control group was under a simple western medicine treatment plan, while the study group was under an integrated traditional Chinese and western medicine treatment plan. The overall efficacy, severity of anal pruritus, time to eliminate clinical symptoms, and anxiety and depression scores of the two groups of patients under different treatment plans were compared. Results: After two weeks of treatment, the total effective rate of the study group was 95.83%, which was significantly higher than that of the control group (82.00%, P < 0.05). After 7 and 14 days of treatment, the anal pruritus scores improved significantly in both the groups, but the study group was superior to the control group, with statistical difference (P < 0.01). The time of disappearance of skin itching and skin damage in the study group was shorter than that in the control group. After 14 days of treatment, the anxiety and depression scores of both groups were lower than those after 7 days of treatment; however, there was statistical difference between the two groups (P < 0.01). Conclusion: In the clinical treatment of anorectal postoperative diseases, such as anal pruritus, the combination of traditional Chinese and western medicine can significantly improve the symptoms of pruritus, shorten the time of disappearance of clinical symptoms, improve depression and anxiety, and create a positive clinical application value in promoting the rehabilitation of patients and improving their quality of life.
Causes and Effect of Domestic Violence against Women in Pakistan : An Analytical Study
Authors: Falak Nabeela
Published: January 2023

Purpose: Despite of implementation of many laws and legislation in Pakistan, domestic violence is still present and increasing day by day. The aim of the study is to point out what are the causes and effects of Domestic Violence (DV) against women in Pakistan. The Pakistani scenario has been described and theoretical bases are presented.

Methodology: Research follows the qualitative research method as it is descriptive and analytical in nature. To make the research important, investigative, and analytical, material has also been collected through random survey. Opinions have been collected from women intellectuals, doctors, psychologists and lawyers of the country through a questionnaire.

Findings: Domestic violence is not an appropriate subject for assessment, interventions, or policy reforms in Pakistan because it usually occurs within the family. According to surveys, between 35% and 70% of intimate relationship violence occurs in Pakistan. Major factors contributing to domestic violence in Pakistan include women's low levels of education and empowerment, misconceptions about Islamic beliefs, traditional customs, poverty, the dowry system, having a girl child, infertility, and drug and alcohol usage. Due to these reasons women are physically, verbally and emotionally, psychologically, sexually abused. Slapping beating, kicking against women cause physical problem.

Implications: Research proves that the risk of attempting suicide is four times more in the victim of domestic violence and they are likely to develop stress, depression, and drug dependency. Study reveals that a large number of women suffer with domestic violence in Pakistan and the causes identified are preventable. Further research is also needed in this regard.
Pandemi Sürecinde Devletin Geri Dönüşü: Fransa ve Türkiye Örnekleri
Authors: MERİ Temel , SIDAL Süleyman
Published: January 2023

Bu çalışmada pandemi sürecinde devletin rolü ve işlevleri Fransa ve Türkiye örnekleri üzerinden karşılaştırmalı olarak ele alınmaktadır. Kovid-19 pandemisinin kamu sağlığı güvenliği açısından yarattığı aciliyet, şok ve kriz ortamı, kamusal otoritelerin önlem alma pratiklerini dönüştürürken her ülkenin, sınırlarını ve güvenlik politikalarını yeniden gözden geçirmesine yol açmıştır. 1980’lerden itibaren refah politikalarından rekabetçi politikalara geçiş, ulusal sınırların esnekleşip uluslararası sermayeye açılması; küreselleşme ve kozmopolitleşme yönünde güçlü bir irade olduğu sanısını yaratmıştır. Ancak pandeminin yarattığı koşullara verilen tepki bunun aksi yönde sonuç vermiştir: Korumacı ekonomi politikalarının, gelir dağıtıcı yaklaşımının yanı sıra ulusal sınırların ve milliyetçi reflekslerin yükselişine şahit olunmuştur. Bu çalışmada bu gelişmelerin pandemi dönemi ile sınırlı ve geçici bir refleks olmayıp post-pandemik toplumsal koşullarda da süreceği iddia edilmekte ve bu süreci anlamak için devletin dönüşümü üzerinden bir okuma önerilmektedir. Çalışmada, hukuki bilgi ve belgelerin yanı sıra aktörlerin açıklamaları ve basına yansıyan haberler incelenmekte ve bahsi geçen dönüşümün sebepleri, mahiyeti ve olası sonuçları betimleyici ve yorumlayıcı yöntemle ele alınmaktadır.
Anayasal Bir Hak Olarak Dilekçe Hakkının Etkinliğinin Değerlendirilmesi
Authors: GÜNER YAŞAR Gizem
Published: January 2023

Dilekçe hakkı, bireylerin kendileriyle ya da kamu ile ilgili istek, dilek ve şikayetlerini, bireysel ya da toplu olarak ilgili kamu makamlarına sunma hakkıdır. Bu hak, demokratik sistemlerin sağlıklı ve etkili işlemesi açısından oldukça önemlidir. Dilekçe hakkı hem Türkiye’de hem de Batılı ülkelerde oldukça köklü bir geçmişe sahiptir. Zamanla anayasal bir hak haline gelen dilekçe hakkı, toplumun her kesiminden bireyin istek ve dileklerini yönetime iletme imkanı sağlamıştır. Ancak Anayasa ve ilgili kanunlardaki düzenleniş biçimi, bireylerin beklentilerine cevap vermekten uzak görünmektedir. Dilekçe hakkının kullanım oranları ile bireylerden gelen istek, dilek ve şikayetlerin karara bağlanmasındaki başarı oranları etkinliğin değerlendirilmesinde önemli kriterlerdir. Bunlara ilişkin sayısal veriler yüksek görünse de Meclisin bu süreçteki tek işlevi dilekçeleri kabul veya reddetmektir. Bireylerin istek, dileklerini sonuçlandırma ya da şikayetlerine çözüm bulma konusunda Meclisin bağlayıcı bir karar alma yetkisi yoktur. Bu yüzden geçmişten günümüze hakka yönelik tüm iyileştirme çalışmalarına rağmen, dilekçe hakkı yönetim üzerinde hala “yumuşak” bir baskı aracıdır.
¿Hasta aquí sí llegarás? Una mirada decolonial sobre la investigación social en John Dewey
Authors: Di Berardino María Aurelia
Published: January 2023

En el capítulo dedicado a la investigación social, John Dewey remite, en su Lógica, a la distinción entre ciencias naturales y sociales. La cuestión de las diferencias entre ambas adquiere articulaciones diversas que giran en torno a un eje central: la plausibilidad de que la investigación social pueda generar —como su par de las ciencias naturales— modificaciones existenciales que le otorguen materialidad a dicho proceso.

A partir de este punto, abordaremos dos objetivos:

analizar la propuesta decolonial, postabismal, de Boaventura de Sousa Santos en diálogo con algunos presupuestos del pragmatista en torno a la potencia metodológica de la investigación de las ciencias naturales. Aspecto que vuelve visible el entramado que une la pretensión metodológica de Dewey con el marco general de la epistemología moderna.

establecer una posible traducción de los modos en que ambas epistemologías resultan complementarias.