bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: Primary graft failure due to a reversed lenticule in Descemet Stripping Automated Endothelial Keratoplasty
Authors: Kate Anahita , Basu Sayan
Published: September 2022

Introduction and importance: This report details the clinical features and management in a case of Descemet stripping automated endothelial keratoplasty (DSAEK) which had primary graft failure (PGF) due to an inverted yet attached lenticule.

Presentation of case: A 66-year-old gentleman had poor visual recovery in the right eye after undergoing cataract surgery 12 years prior to presentation. The visual acuity was counting fingers and examination revealed endothelial decompensation. The patient underwent a DSAEK and postoperatively had a well attached lenticule. However, the cornea was edematous three weeks after the surgery and optical coherence tomography (OCT) revealed a reversed lenticule. The patient underwent a repeat DSAEK and had an uneventful postoperative course. The visual acuity was 20/40 after 7 months with a clear cornea and a well attached graft.

Discussion: PGF is a rare complication following DSAEK which occurs due to poor endothelial function of the donor graft. Insertion of a reversed lenticule may get overlooked as a cause of PGF unless the graft edge profile is examined on an OCT scan. The graft in the current case was well attached despite its inverted position suggesting that graft adherence is perhaps not a function of the corneal endothelial pumps in isolation and may be driven by factors such as the intraocular pressure.

Conclusion: A reversed DSAEK lenticule may have normal adherence to the host stroma and must be considered in cases with PGF. OCT of the graft edge is required for diagnosis before performing a repeat keratoplasty.
Prevalence of common mental health problems and associated factors among university students visiting Supara mental health service: A cross-sectional study
Authors: Kirdchok Pantri , Kolkijkovin Varuna , Munsukpol Wanida , Chinvararak Chotiman
Published: September 2022

Background: Early studies found that the mental health problems rate was relatively high in university students. We aimed to investigate the prevalence of mental problems and associated factors in university students.

Methods: We conducted a cross-sectional descriptive study at Supara mental health service in the Faculty of Medicine Vajira Hospital between February 2020 to June 2021. The primary outcome was the prevalence of psychiatric diagnosis according to the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10). The secondary assessments included the Patient Health Questionnaire-9 (PHQ-9), 8 items from the Mini International Neuropsychiatric Interview (MINI) to assess suicidal risk (8Q), and the Thai Mental Health Indicator (TMHI-15). The prevalence of mental health problems was presented by frequency and percentage. In addition, multivariable regression analysis was used to identify potential predictors of mental health problems.  

Results: A total of 184 participants (62% female; mean age = 22.49 years (SD 3.93) were recruited. The depressive disorders, adjustment disorders, and anxiety disorders rates were 57.1%, 15.2% and 13.6%, respectively. Grade point averages (GPAs) below 3.0 (OR=3.09, 95%CI: 1.17-8.14) and a family history of mental disorder (OR=3.40, 95%CI: 1.10-10.48) were significant associated factors of moderate to severe mental health problems. Detecting and screening these factors may help the university to provide early detection and treatment for students.

Conclusions: Depressive disorders were the most common mental health disorders. Females, low GPAs and a family history of mental disorder were predictors of moderate to severe mental health problems.
The company's ecosystem
Authors: Popov Evgeniy , Simonova Viktoriya , Chelak Igor' , Minakir Pavel , Porfir'ev Boris
Published: September 2022

The monograph is devoted to modeling the ecosystem of the company. The influence of social networks on the development of business processes is shown, the principles of the use of new digital communication technologies are given and the drivers of the economy in the conditions of the coronavirus pandemic are substantiated. The structure of industrial ecosystems in the digital economy is given, the economic effects of digitalization of inter-firm interactions are discussed, the idea of the network potential of a firm in the conditions of digitalization of economic activity is substantiated. The application of digital platforms as the basis for the functioning of economic ecosystems is considered. The possibilities of assessing the development of innovative ecosystems and the typology of their models are given. The factor model of the economic ecosystem is considered. The stakeholder model of the ecosystem and its analytical model are described. The differentiation of stakeholders' impact on ecosystem institutions and the difference in the levels of interaction between the core of the system and stakeholders are discussed. The principles and ideas of the theory of ecosystem analysis are presented.
It is addressed to researchers and university professors specializing in the fields of economic theory, institutional economics, regional economics, microeconomics and minieconomics.
Formation of Students’ Creativity by Means of Electronic Environment Moodle
Authors: Aleevskaya Yu. , Burmistrova N. , Zabudskiy G. , Sokur E. , Shamis V.
Published: September 2022

The authors investigate the problem of the formation of creativity of students of economic university. The importance of solving this problem in the context of improvement of the quality of training of graduates of higher education from the standpoint of professional orientation of training is emphasized. The article highlights the role of e-learning environment Moodle (modular object-oriented dynamic learning environment) as a means of formation of the creativity of future bachelors of economics. The possibilities of electronic environment Moodle are demonstrated for creating of training courses, filling them in the form of electronic resources (lectures, practical tasks, questionnaires, tests, forums, etc.), providing interactive interaction of subjects of the educational process. In the course of the study, a table of indicators of the level of formation of the creative-activity component of students’ mathematical competence was built to identify creativity. Based on the results of the pedagogical experiment, the assessment of the formation of the creative-activity component of mathematical competence of future bachelors was carried out. The article presents the results of generalized indicators of the dynamics of the formation of the creative activity component at the subject, interdisciplinary and professional stages of multilevel mathematical training in economic university.
About the problems of mathematical training of future economists
Authors: Maskina M. , Davydochkina S.
Published: September 2022

This article is written on the basis of the analysis of scientific and methodological literature over the past two years and the personal experience of the authors of conducting mathematical disciplines with cadets and full-time students using distance learning technologies. The purpose of this article was to substantiate the relevance and significance of using a set of individual homework assignments containing applied tasks of an economic orientation for generalizing the material and acquiring the skill of synthetic activity. The study was conducted for four semesters in the classroom in the disciplines of the mathematical cycle with students of economic specialties. As a result of the work carried out, the authors were able to identify and analyze the most typical problems associated with the mathematical training of future economists. One of the ways to solve them is to use workbooks with tasks of economic content, the peculiarity of which lies in the structure of construction: around the central core (which is chosen as one of the basic economic concepts), several tasks are formed that reinforce various topics of the discipline being studied.
Methodology of Training Managers in the Higher Education Institution of Physical Culture According to Statistics in Accordance with the Relevance of the Transition to Domestic Software
Authors: Zubarev S.
Published: September 2022

The article describes the content, structure and features of the work program of the discipline “Statistics” in the direction of training 38.03.02 “Management”, the training profile “Management of the organization”, updated taking into account the new requirements of the digital economy, methodological recommendations of the Ministry of Digital Development, Communications and Mass Media of the Russian Federation for the transition of state-owned companies to the predominant use of domestic software and professional standards prepared in accordance with the requirements of the Federal State Educational Standard and professional standards. General professional competencies, labor functions, labor actions, necessary knowledge and skills are given. To demonstrate the acquired knowledge, skills and ability to perform labor functions in professional practice, achievement indicators are formulated.
Effect of botulinum toxin on improving quality of life in patients with chronic migraine
Authors: Marzęda Magdalena , Swatko Tomasz , Blicharz Agnieszka , Stachura Tomasz , Kamieniak Maciej , Jarosz Piotr , Kobiałka Izabela
Published: September 2022

Introduction and purpose: Migraine is a chronic condition affecting up to 10% of the adult population in Poland. Migraine pain is severe and may be accompanied by nausea or vomiting, as well as hypersensitivity to light, sounds or smells. Chronic form of migraine means the occurrence of headache a minimum of 15 days per month, for a period of at least three months, of which eight days or more of pain meet the criteria for migraine pain. The chronic form of migraine is targeted for treatment with botulinum toxin, a neurotoxin secreted by the bacteria Clostridium botulinum.

Brief description of the state of knowledge: The pathogenesis of migraine is still unknown. There are many hypotheses explaining the origin of migraine pain, of which the most plausible seems to be the theory involving the trigeminal nerve system, as well as trigger points in the head and neck area. Their activation leads to the triggering of pain. Botulinum toxin has been used to treat migraine for several years. The only registered drug is Botox, the effectiveness of which has been confirmed in clinical studies. The preparation is administered by injection into the muscles of the head and neck region in cycles with an interval of 12 weeks. Botulinum toxin works by blocking the release of inflammatory and pain mediators from the trigeminal nerve endings.

Summary: Chronic migraine refers to the occurrence of headache for more than half of the month, which significantly reduces the quality of life of people worldwide. Migraine headaches often refractory to pharmacological treatment may respond well to botulinum toxin type A. Therapy should be under the supervision of a neurologist, who will familiarise the patient with the expected effects of botulinum toxin treatment before starting treatment.
Multiple sclerosis and pregnancy as a significant social problem in modern neurology
Authors: Kamieniak Maciej , Wolanin Natalia , Marzęda Magdalena , Jarosz Piotr , Kobiałka Izabela , Blicharz Agnieszka , Swatko Tomasz
Published: September 2022

Along with the increasing number of reported cases, multiple sclerosis, one of the main causes of disability among young adults, is nowadays an increasingly common health problem. Considering the fact that it occurs mainly between 20 and 40 years and affects women more often, the question of the impact of the disease on pregnancy becomes obvious. In view of the wide selection of drugs for various purposes and often highly individualized forms of therapy, it seems also important to determine the safety profile of these agents in relation to the health of the pregnant woman and the fetus. All of this is a significant challenge for neurologists and obstetricians and is the subject of many research and studies. The awareness of society, especially women, in the face of the growing problem seems to be equally important. This paper summarizes the current state of knowledge on these issues.
Fundamentos de programación: PYTHON
Authors: Toro Bonilla Miguel
Published: September 2022

Este volumen de fundamentos de programación en Python tiene como objetivo explicar los conceptos básicos de esta materia. Aunque cada lenguaje tiene sus particularidades, es posible afirmar que van convergiendo hacia elementos comunes a todos ellos. De ahí que intentemos partir de esas ideas compartidas por los principales lenguajes actuales para ir extrapolando posteriormente conceptos de unos a otros. En este sentido, se van a abordar conceptos en Python comunes con Java que pueden ser extendidos a otros. El diseño de tipos ocupará un lugar central en este volumen en cuya parte final se incluyen varios ejemplos. Python se presenta desde un enfoque basado en iterables y reutilización de funciones. El material que conforma este manual procede de la experiencia acumulada tras varios años de enseñanza de la asignatura de Fundamentos de Programación en la Universidad de Sevilla.
Investor Attention and Option Returns
Authors: Choy Siu Kai , Wei Jason
Published: September 2022

This paper examines the attention effect in the options market. We show that option investors (especially retail investors) buy more calls and puts on both daily winner and loser stocks, and this buying pressure leads to an overvaluation, as shown in subsequent lower hedged returns. The overvaluation is due to a combination of differences of opinion, risk aversion, and margin requirements. The economic magnitude is large. For instance, a zero-financing portfolio involving options on loser stocks renders an alpha of 2.90% per month. Aside from contributing to the broad literature of investor attention versus asset returns, our study also sheds light on an important yet largely neglected topic: the impact of margins on option trading and pricing.

This paper was accepted by Lukas Schmid, finance.

Funding: Financial support from King’s College London, the University of Toronto, and the Social Sciences and Humanities Research Council of Canada [Grant 435-2018-0514] is gratefully acknowledged.

Supplemental Material: Data and the internet appendices are available at https://doi.org/10.1287/mnsc.2022.4557 .
On the Participation, Competition and Welfare at Customer-Intensive Discretionary Service Platforms
Authors: Liu Yixuan , Wang Xiaofang , Gilbert Stephen , Lai Guoming
Published: September 2022

Problem definition: We investigate the participation, competition, and welfare at platforms that focus on customer-intensive discretionary services, such as healthcare, legal, and business consulting. Academic/practical relevance: Such platforms have recently emerged in practice to provide a venue for independent professionals and service seekers to match online. Methodology: We develop a strategic queueing model, where the platform sets the commission rate, upon which service providers decide participation, service quality, and price, and consumers make service acquisition. Results: First, our study reveals that with heterogeneous consumers, the participating service providers may engage in both price and service competitions if the number of them is either small or large. They compete for attractive consumers in the former and for market share in the latter. In these regions, more service providers joining the platform can result in a lower service price and a higher service quality. Whereas, if the number of participating service providers is intermediate, only service competition arises, so that a higher service quality is associated with a higher service price. Second, we find that in our main model, the platform may set the commission rate sufficiently high to limit the number of participating service providers, so as to prevent intense price competition. In contrast, if the platform also controls the service price, it may set a higher service price and a lower commission rate, which boosts the participation of service providers and improves their service quality. As a result, platform price intervention may not only benefit the platform and the service providers, but also the consumers. Managerial implications: These insights not only complement prior literature, but are also useful for understanding and the design of such service platforms in practice.

Funding: X. Wang received financial support from the National Natural Science Foundation of China [Grant 72071204].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.1152 .
Characteristics of Kidney Failure Patients in Sardjito Hospital Yogyakarta
Authors: Ihsana Nuni , Yuniasih Dewi , Purwanto Barkah
Published: September 2022

Chronic kidney disease (CKD) has become a serious public health problem. The aim of this study was to identify the characteristics of patients at high risk of developing kidney failure. The research subjects were analyzed as many as 57 subjects, showing that male sex (61.4%) suffered more from CKD than women (38.6%). The mean age was 37.84 Â± 16.16 with a median length of Â Continuous Ambulatory Peritoneal Dialysis (CAPD) of 36 months. Our study found 45.6% of the patients had an undergraduate degree, followed by 38.6% of the patients had a high school education. Further analysis is needed with more age groupings so that the characteristics of patients with kidney disease (CKD) can be known in detail from various elements of society.Â
Comparative Study on TGF-β Expression of Large Continues and Small Continues Stitch Technique Using Polyglecaprone 25 on Abdominal Skin Incision in Rattus Novergicus
Authors: AS Dhyas Munandar
Published: September 2022

Ideal closing of the abdominal wound will provide strength and prevent infection. Abdominal wall closure method is an important aspect of effective incision closure, besides the choice of suture material. TGF-β generally involved in wound healing process. The suture technique is also important in wound healing process. This study aims to compare the large stitch technique with the small stitch technique for abdominal skin closure. Twenty rats were used in 4 groups. The small stitch group received small tissue bites of 5 mm from wound edge, and the large tissue group received large bites of 10 mm from wound edge. The incision of the skin was closed by running suture using polyglecarprone 25. Animal model were euthanized on the 4th and 7th day post incision. Tissue section were examined using immunohistochemistry method to measure TGF-β expression. The results were analyzed using t-test and the effect size. Rats in the small stitch group had higher TGF-β expression on day 4th and 7th than those in the large stitch group. TGF-β expressions in the small stitch group were 0,87 -fold greater on day 7th than day 4th and were 0,71 -fold greater in the large stitch group (p = 0,410). The significance analysis on day 4th with a result of 0,082 and day 7th with a result of 1.48, which means day 7th showed high effect (Cohen's d> 0.8) on wound healing than day 4th. In conclusion, polyglecaprone 25 use as a suture material on the day 7th showed a high effect in terms of TGF- β expression.
Albumin Description of Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients in Sardjito Hospital Yogyakarta
Authors: Purwanto Barkah , Yuniasih Dewi , Puspitasari Metalia
Published: September 2022

Albumin profile is an important sign of nutritional status as a quality-of life parameter, whereas hypoalbuminemia has been shown to be associated with a high mortality rate for patients with End Stage Renal Disease (ESRD) undergoing dialysis including CAPD. The study was conducted to determine serum albumin levels in patients with ESRD undergoing CAPD therapy. The study was conducted in a cross-sectional manner on ESRD patients who were still actively undergoing CAPD in the outpatient Installation of Dr. Sardjito Hospital Yogyakarta until November 2018. Subjects were examined for serum albumin levels. There were 57 research subjects with the category of albumin levels <3.5 g / dL as many as 19 (33.3%), between 3.5-4.0 g / dL as many as 27 (47.3%) and albumin levels> 4.0 g / dL of 11 (19.3%). There were no significant differences in all age groups, BMI and duration of CAPD. Albumin profile can be an independent parameter of quality of life and even a predictor of mortality in CAPD patients because it does not depend on age group, BMI and length of CAPD
Hepatoprotective Effects Of Papaya Leaves Extract (Carica Papaya L.) With Increased Dose: A Study Of Total Bilirubin Levels Of Wistar Rats That Given Paracetamol
Authors: 'aisy Adhani Rihhadatul , Ratnaningrum Kanti , Nugraheni Dyah Mustika
Published: September 2022

Incorrect use of paracetamol can cause overdose and cause liver damage. Papaya leaves is a plant that has the potential as hepatoprotective because it contains flavonoids, saponins, tannins, alkaloids, triterpenoids and vitamin E. The aim of this study was to prove the hepatoprotective effect of papaya leaf extract on the total bilirubin levels of Wistar rats given paracetamol. This research was conducted using a post test only control group design method and used 24 wistar rats grouped by simple random sampling into negative control (K-), positive control (K +), treatment 1 (PI), and treatment 2 ( PII). PI and PII groups were given papaya leaf extract 75 mg / kgBB rats / day and 150 mg / kgBB rats / day for 7 days. On days 5 to 7, the K +, PI, and PII groups were given paracetamol 600 mg / kgBW rats / day. Samples were taken on day 8 and total bilirubin levels were measured on day 9 then analyzed using One Way Anova and Post Hoc LSD test. There are significant differences in all groups based on the results of the One Way Anova test with p value= 0.000. The results of the LSD Post Hoc test showed significant differences in the K- group with K + (p = 0,000), K- with PI (p = 0.027), K + with PI (p = 0,000), K + with PII (p = 0,000), PI with PII (p = 0.004), and there was no significant difference between the K- and PII groups (p = 0.397). There was a hepatoprotective effect of papaya leaf extract on Bilirubin total levels in Wistar rats treated with paracetamol.
Bleeding Complications of a Tracheostomy Stoma Covid-19 Patients Related to Therapy Heparin
Authors: Abdullah Adnan , Widuri Asti
Published: September 2022

Tracheostomy measures will increase as the number of ICU patientsincreases. The main indication for tracheostomy in intensive carepatients is to reduce dead space and reduce the risk of laryngealdamage due to long-term intubation. In the era of the Covid-19pandemic, tracheostomy procedures require consideration of thebenefits for patients and the risk of spreading the virus thatendangers health workers. In this case, it is reported that theimplementation of a tracheostomy with a safe procedure in patientswith severe Covid-19 infection and complications of stoma bleeding6 days after the tracheostomy procedure with risk factors for theuse of heparin anti-coagulant drugs
Mini Review: The Potential of Piperine in Black Pepper in Improving Brain Work
Authors: Dewanto P Dandy , Kinanthi Putri , Aqidatul Nurul , Sistharani Naila , Yuniasih Dewi
Published: September 2022

This study aims to determine the effect of piperine as an antidepressant and the potential to improve brain cognitive function. Researchers conducted a literature review related to piperine's potential for brain work using databases such as PubMed, Google Scholar, Cochrane Library. Search the relevant research literature using the keywords "Piperine in black pepper" or "piperine and brain effects". One of our conclusions is that piperine's cognitive-enhancing effects may occur in part through its cytoprotective and AChE inhibitory effects in the hippocampus.
A Case Report of Asymptomatic Covid-19 Infection Death in Gemelli Pregnancy
Authors: Soniasari Soniasari , Fauziah Munaya
Published: September 2022

We present the case of a 23-year-old woman, G1P0A0, Gemelli (twins) with a gestational age of 38 weeks. The patient was referred to a type C referral hospital with complaints of low back pain without other symptoms. Antigen Rapid Test Swab examination with positive results and nasopharyngeal and oropharyngeal swab sampling for Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) examination of patients gave positive results with asymptomatic infection (without symptoms). Gemelli's pregnancy, which is considered a high risk and COVID-19 infection in the patient, resulted in parturition being performed by Sectio Caesarea. Both babies were born alive, but the first baby died on the first day, followed by the second baby on the second day after birth and then the mother experienced a worsening of the condition, namely in a coma placed in the ICU, on the third postpartum day she experienced respiratory and cardiac arrest and was declared dead.
Mesenchymal Stem Cells Therapy in critical COVID-19 patient: a case report
Authors: Sukirto Novi , Arifin Zainul , Sumardi Sumardi , Purwanto Barkah , Mansur Auliya Azisah , Sistharani Naila
Published: September 2022

COVID-19 pneumonia with critical symptoms causes acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndromes (MODS) which can be severe complications until death. One therapy for Covid-19 critical was to suppress the effects of cytokine storms, which was administered by Mesenchymal Stem Cells therapy. In this case, we will report a case of COVID-19 with a critical patient that was given MSC therapy there were good outcomes in this case which were improvement of the clinical symptoms and prevent death.
 

ABSTRAK

Pneumonia COVID-19 dengan gejala kritis menyebabkan sindrom gangguan pernapasan akut (ARDS) dan sindrom disfungsi organ multipel (MODS) yang dapat menjadi komplikasi berat hingga kematian. Salah satu terapi kritis Covid-19 adalah menekan efek badai sitokin, yang dilakukan dengan terapi Sel Punca Mesenkim. Dalam kasus ini, kami akan melaporkan kasus COVID-19 dengan pasien kritis yang diberikan terapi MSC ada hasil yang baik dalam kasus ini yaitu perbaikan gejala klinis dan mencegah kematian
Determinants of Adolescents' Desire to Quit Smoking in Indonesia: Data Analysis of the 2014 Global Youth Tobacco Survey
Authors: Sari Mega Puspa , Ayunin Elia Nur , Setyowati Yuli Dwi
Published: September 2022

Background: The high prevalence of smoking is not only among adults but also among children and adolescents. Almost all adolescent smokers wish to quit smoking. They are aware of the dangers of cigarettes, tobacco, and other types so they are motivated to quit smoking. This study aims to determine the determinants of the desire to quit smoking in Indonesian students, using a cross-sectional study design. Method: This study is a secondary data analysis of the Global Youth Tobacco Survey (GYTS) in Indonesia in 2014. The sample of the study was all students in grades 7-9 in Indonesia who participated in the 2014 GYTS and had complete data, namely 5,986 people. Logistic regression statistical test analysis was used to determine the relationship between the determinants and the desire to stop smoking in adolescents. Results: Adolescents who want to quit smoking are 92.1%. There is a relationship between adolescents who have tried cigarettes and other types of tobacco on the desire to stop smoking behavior (OR=11,3; 95% CI=5,216-24,615; p<0.025). There is a relationship between the dangers of smoking from family discussions on the behavior and desire of adolescents to stop smoking (OR=2,1; 95% CI=1,213-3,784; p<0.025). Conclusion: Family support and motivation can assist adolescents in reducing smoking habits by monitoring and reminding adolescents of the purpose of quitting smoking, and by inviting adolescents to consult and take therapy with Public Health Services.
The Hamiltonian extended Krylov subspace method
Authors: Benner Peter , Faßbender Heike , Senn Michel-Niklas
Published: September 2022

An algorithm for constructing a $J$-orthogonal basis of the extended Krylov subspace$\mathcal{K}_{r,s}=\operatorname{range}\{u,Hu, H^2u,$ $ \ldots, $ $H^{2r-1}u, H^{-1}u, H^{-2}u, \ldots, H^{-2s}u\},$where $H \in \mathbb{R}^{2n \times 2n}$ is a large (and sparse) Hamiltonian matrix is derived (for $r = s+1$ or $r=s$). Surprisingly, this allows for short recurrences involving at most five previously generated basis vectors. Projecting $H$ onto the subspace $\mathcal{K}_{r,s}$ yields a small Hamiltonian matrix. The resulting HEKS algorithm may be used in order to approximate $f(H)u$ where $f$ is a function which maps the Hamiltonian matrix $H$ to, e.g., a (skew-)Hamiltonian or symplectic matrix. Numerical experiments illustrate that approximating $f(H)u$ with the HEKS algorithm is competitive for some functions compared to the use of other (structure-preserving) Krylov subspace methods.
Exploring the impact of total quality management initiatives on construction industry projects in Pakistan
Authors: Afzal Nimra , Hanif Aamer , Rafique Muhammad
Published: September 2022

The impact of total quality management on organizational performance has been studied extensively, however, the impact of total quality management initiatives on project performance is an area of ongoing research. The key objective of this research is to explore the impact of total quality management initiatives on project performance in the construction industry of Pakistan. Data was collected from 326 personnel working at different management levels across some of the leading construction firms operating in Pakistan. Analysis revealed that operational focus, management commitment, and employee involvement were deemed as dominant total quality management factors affecting project performance in the construction industry. Mediation analysis revealed a significant relationship between employee involvement and project performance mediated by management commitment. Research limitations and directions for future research have also been identified.
Analysis of water quality over non-condensable gases concentration on steam used for sterilization
Authors: Miguel Emerson Aparecido , Laranjeira Paulo Roberto , Ishii Marina , Pinto Terezinha de Jesus Andreoli
Published: September 2022

Background

Non-condensable gases (NCGs) are all gases that do not undergo liquefaction during the saturated steam sterilization process. During a sterilization cycle, the NCGs presence inside the chamber is one of the biggest threats to the sterilization process compromising process validation and product quality.

Methods

In this work, 170 testing of NCGs concentrations performed between September 2016 and August 2021 were carried out by Orionce Serviços de Metrologia Ltda (Barueri, SP, Brazil), according to EN285:2015 procedure. For steam generation, the types of water used were softened water (SW), one-step reverse osmosis (RO), purified water (PW), and water for injection (WFI). The data obtained were analyzed using Minitab® software, version 18.1, to identify a relationship between the water quality used for steam generation and the concentration of non-condensable gases determined into equipment qualification.

Findings

From total tests performed, 109 tests passed, and 61 tests failed, representing 64.2% and 35.8%, respectively. A higher failure rate was observed in terms of concentration of non-condensable gases in systems that used purified water for steam generation (64.7%), followed by softened water (55.6%), one-step reverse osmosis (42.9%), and water for injection (7.6%).

Conclusion

System processes using WFI for steam generation showed better results for steam quality approvement, in terms of NCGs concentration, compared to softened, purified, or reverse osmosis water treatments in the concentration of non-condensable gases in steam used for sterilization processes of industrial utilities.
Non-local validated parametrization of an agent-based model of local-scale Taenia solium transmission in North-West Peru
Authors: Pizzitutti Francesco , Bonnet Gabrielle , Gonzales-Gustavson Eloy , Gabriël Sarah , Pan William K. , Pray Ian W. , Gonzalez Armando E. , Garcia Hector H. , O’Neal Seth E. ,   for the Cysticercosis Working Group in Peru
Published: September 2022

The pork tapeworm, Taenia solium, is the cause of a preventable zoonotic disease, cysticercosis, affecting both pigs and humans. Continued endemic transmission of T. solium is a major contributor of epilepsy and other neurologic morbidity, and the source of important economic losses, in many rural areas of developing countries. Simulation modelling can play an important role in aiding the design and evaluation of strategies to control or even eliminate transmission of the parasite. In this paper, we present a new agent based model of local-scale T. solium transmission and a new, non-local, approach to the model calibration to fit model outputs to observed human taeniasis and pig cysticercosis prevalence simultaneously for several endemic villages. The model fully describes all relevant aspects of T. solium transmission, including the processes of pig and human infection, the spatial distribution of human and pig populations, the production of pork for human consumption, and the movement of humans and pigs in and out in several endemic villages of the northwest of Peru. Despite the high level of uncertainty associated with the empirical measurements of epidemiological data associated with T. solium, the non-local calibrated model parametrization reproduces the observed prevalences with an acceptable precision. It does so not only for the villages used to calibrate the model, but also for villages not included in the calibration process. This important finding demonstrates that the model, including its calibrated parametrization, can be successfully transferred within an endemic region. This will enable future studies to inform the design and optimization of T. solium control interventions in villages where the calibration may be prevented by the limited amount of empirical data, expanding the possible applications to a wider range of settings compared to previous models.
A justiça infra-diocesana no império português (c. 1514-1755). Raízes do modelo, normativas, ação e geografia da rede
Authors: Paiva José Pedro , Muniz Pollyanna Gouveia Mendonça , Britto Michelle
Published: September 2022

Este artigo trata da justiça infra-diocesana ou justiça diocesana periférica nas dioceses do império ultramarino português, desde o mundo atlântico à Ásia, entre 1514 e 1755. Baseia-se numa gama variada de fontes documentais, a maior parte inéditas, de proveniência secular e eclesiástica, produzidas por indivíduos e instituições sediadas no reino e/ou ativas no império. Utiliza abordagens da história global e comparativa, propondo perspetivas não aprisionadas a fronteiras geográficas e cronológicas estanques, nem circunstritas a lógicas explicativas locais. Propicia uma visão problematizante da origem do sistema, das razões que determinaram a sua aplicação, da sua atuação e da geografia que a rede assumiu em diversas dioceses. Argumentar-se-á que o seu funcionamento, que teve capacidade adaptativa aos cenários multifacetados onde se instalou, é mais um elemento que ajuda a compreender que o padroado real não impôs limites insuperáveis à afirmação das prerrogativas episcopais no império.
A violência Senhorial nas Inquirições Gerais de 1288 e Sentenças de 1290
Authors: Castro Portugal João
Published: September 2022

A violência atravessa todas as sociedades, presentes e passadas. E em tempos medievos, a violência era percecionada de forma muito diferente da dos nossos dias. A violência em muitos casos era considerada lícita, e até mesmo necessária, pelos homens desses tempos.

O presente artigo tem como objetivo principal compreender a violência de cariz senhorial em Portugal nos finais do século XIII, através dos testemunhos registados nas Inquirições Gerais de 1288 e das respetivas sentenças de 1290. É também um desígnio entender, no contexto das lutas entre os diferentes poderes, se a relação entre o mundo senhorial e as políticas de centralização do poder régio, resultaram em ações violentas. Para tanto analisaram-se as diferentes práticas de violência, as suas justificações, os seus agentes e as suas vítimas, bem como se procurou escrutinar a ação do monarca no controlo da violência, permitindo assim entender as tensões existentes, as suas circunstâncias e as suas intenções.

Palavras-chave: Violência – Inquirições Gerais - Poder Senhorial – Poder régio – Abusos Senhoriais
An Empirical Study for Implications to Respond the Crisis of Local Population Decline in South Korea
Authors:   Crisis and Emergency Management: Theory and Praxis, Kwon Ja Kyung
Published: September 2022

In the non-Capital area of South Korea, it was found that the cause of the population decline was not solely due to the recent low birth rate. The severe population decline in the non-Capital area is due to the migration of the population to the Capital area. Therefore, this study looked at what regional development factors affect the local population increase. As a result of the regression analysis, the factors affecting population decline were the old housing rate, % of population in library service area, ratio of single-person households over 65, and water supply rate. As factors affecting population growth, green rate, number of residents in charge per 119 safety center, ratio of the school-age population within the elementary school service area, and urban park area per 1,000 people were derived. Based on the results of the empirical analysis, in order to respond to the crisis of local population decline, policies were proposed to remove the factors of population decrease and to activate the factors of population increase in non-Capital areas.
Optimizing factors for the efficient expression and purification of spao and lamb from Salmonella typhi
Authors: Latif Kunza , Naz Shagufta , Altaf Imran , Huang Jian dong , Bashir Rasheeda , Aslam Farheen , Shaozhen Xing7
Published: September 2022

We optimized the expression and purification of outer membrane proteins SpaO and LamB from Salmonella typhi. We investigated various factors in the expression and purification processes, including the use of isopropyl β-d-1 thiogalactopyranoside (IPTG), imidazole, and urea. First, PCR amplification was carried out on SpaO and LamB genes. The genes were then cloned in pTZ57R/T, and then expressed in pET28a vector and transformed into Escherichia coli BL21 (DE3). Gene insertion was confirmed by enzymatic digestion with NdeI and XhoI. Inclusion bodies expressing recombinant SpaO and LamB were induced with 200 and 400 µL 0.5 mM IPTG, respectively. The formed protein inclusion bodies were then isolated from the pellet and solubilized in IB buffer containing 8 M urea for SpaO and 6 M urea for LamB. Proteins were refolded by dialysis in 3M urea. Purified proteins with nickel-nitrilotriacetic acid affinity chromatography and eluted with buffer containing 250 mM imidazole for SpaO and 150 mM imidazole for LamB. The protein expression profiles were analyzed by SDS-PAGE, which identified the 33 and 49 kDa bands corresponding to rSpaO and rLamB. Western blotting Purification was carried out by nickel affinity resin with 250 mM and 150 mM imidazole for rSpaO and rLamB and refolded through stepwise dialysis with anti-His tag antibodies confirmed their expression. These optimized methods can be used to generate recombinant proteins for the development of future vaccines.
Dissertação de vestibular
Authors: Nogueira de Sousa Rosângela do Socorro
Published: September 2022

Este artigo tem como objetivo apresentar o resultado de pesquisa desenvolvida como dissertação de mestrado, enfocando a organização do gênero “dissertação escolar” sob o escopo da gramática sistêmico-funcional de Halliday (1985). O material de análise é composto por 44 textos de alunos de pré-vestibular divididos em dois grupos: O primeiro grupo é composto por 22 textos aos quais foi atribuída nota maior que 6,0 (seis) e o segundo grupo é composto também por 22 textos aos quais foi atribuída nota igual ou menor que 6,0 (seis). São colocadas em evidência as estruturas de mensagem (tema e rema) e seu modus operandis no texto como elementos que contribuem para os processos de significação a partir dos padrões de desenvolvimento temático. Os resultados apontam para o fato de que não há diferença entre os tipos de Temas escolhidos nos dois grupos, mas os elementos temáticos e o método de desenvolvimento diferem. No que diz respeito aos padrões de desenvolvimento, nos textos do primeiro grupo, a maior incidência foi do padrão zig-zag e, nos do segundo grupo, do tema reiterado.
Sociossemiótica da cultura e discurso publicitário
Authors: Ike Coan Emerson
Published: September 2022

O presente artigo apresenta as linhas gerais de uma teoria Sociossemiótica da cultura. A partir desse modelo teórico, é possível reescrever as estruturas de poder dos discursos sociais, especialmente a do discurso publicitário.
Dialogismo e Intertextualidade das diferenças presentes na série televisiva Aline
Authors: Botega de Lima Valquiria
Published: September 2022

Resumo: Este artigo tematiza os modos como se manifestam, pelo funcionamento intertextual, o dialogismo e as relações intertextuais no nível das diferenças (paródia) no episódio Aline TPM. Trata-se da série televisiva Aline, nossa materialidade de estudo, exibida por uma emissora de TV aberta brasileira. Considerando o texto como um objeto constitutivamente dialógico e heterogêneo, buscamos analisar como esse episódio dialoga com outros textos e mostrar como são construídas as relações intertextuais parodísticas. Em nosso embasamento teórico partimos de uma reflexão sobre o conceito de dialogismo bakhtiniano (1999), posteriormente abordamos o conceito de intertextualidade, no que tange as colocações advindas, sobretudo, de Koch (1997) e nas considerações acerca da intertextualidade das diferenças nos respaldamos, principalmente, no teórico Sant’Anna (2007). Em termos metodológicos, descrevemos, separadamente, cada cena recortada cuja análise nos permitiu constatar que em relação a TPM há, significando, de um lado o ponto de vista clínico e de outro o ponto de vista humorístico, os quais, vale ressaltar, nunca terão a mesma orientação argumentativa, pois pertencem ao “eixo parodístico”. As retomadas aos gêneros cinematográficos terror com vampiros e faroeste instauraram a paródia, uma vez que tais recuperações são responsáveis pelo estabelecimento do efeito humorístico.
PENGARUH UKURAN PERUSAHAAN LIKUIDITAS DAN PROFITABILITAS TERHADAP PENGUNGKAPAN ISLAMIC SOCIAL REPORTING DENGAN LEVERAGE SEBAGAI VARIABEL MODERASI
Authors: Zuhriyanto Zuhriyanto , Haryono Slamet
Published: September 2022

This study aims to determine whether firm size affects the disclosure of Islamic social reporting, whether liquidity affects the disclosure of Islamic social reporting, and whether profitability affects the disclosure of Islamic social reporting. Then the researcher adds leverage as a moderating variable in the study that can moderate firm size, liquidity and profitability on Islamic social reporting disclosure of Islamic commercial banks in Indonesia. By using disclosure theory which shows that CSR disclosure which is modified into ISR is related to future financial performance and has a good influence on the financial performance of the instution in the long term.
The Master Course Design Process Explained Using General College Botany as a Case Study
Authors: Gaddis Margaret
Published: September 2022

This paper describes the master course design process at the largest institution of higher education in Colorado, USA. The master course design process demonstrated principles of backwards design and employed a team-based approach to course development. The course map was the primary vehicle for communicating the design of the course during development and later for accountability. This case study presented the redesign of General College Botany. The General College Botany curriculum employed authentic assessment and provided an andragogical learning environment. The central authentic assessment in the course was a term-long research project. Other assignments included wiki-building discussions, traditional quizzes, and at-home labs. The accounting of this process and the assignments described for an online science course provide a template for other institutions to follow when considering the implementation of master courses in higher education settings. As botanical curricula continue to be cut from degree programs and the need for remote learning becomes imminent in the modern world, the scaling of educational resources is facilitated by master course design. Master course design promotes accountability and standardization while also affording a well-researched, constructive, and blended learning environment.
El Bachillerato Internacional en Madrid: La expansión silenciosa de la internacionalización
Authors: Curran Marta , Rujas Javier , Castejón Alba
Published: September 2022

La expansión mundial del Bachillerato Internacional (BI) forma parte de una tendencia global de internacionalización de la educación (IE). El programa, sin embargo, adopta distintas formas en distintos contextos nacionales y locales. Este artículo se propone examinar la reciente expansión del BI en Madrid desde la perspectiva de la Economía Política Cultural. Para ello, se basa en entrevistas en profundidad a actores clave, análisis de documentos (legales, técnicos, políticos y mediáticos) y datos cuantitativos secundarios. Madrid ha liderado el crecimiento del BI en España en la última década, aunque esta expansión ha pasado relativamente desapercibida. El artículo muestra que el crecimiento y la penetración de las iniciativas privadas de IE, como el BI, están relacionados con las características sociales y educativas de cada contexto. En particular, los resultados de nuestro trabajo confirman que estos programas tienden a expandirse más intensamente en sistemas educativos descentralizados donde las políticas neoliberales y neoconservadoras fomentan la autonomía, la competencia, la internacionalización y la “excelencia”, como es el caso de Madrid.
Wide binary stars with non-coeval components
Authors: Malkov Oleg , Kniazev Alexey
Published: September 2022

We have the estimated masses of components of visual binaries from their spectral classification. We have selected pairs in which the less massive component looks more evolved. Spectral observations of some of these pairs were made, and at least one pair, HD 156331, was confirmed to have components of different ages. Since mass exchange is excluded in wide binaries, it means that HD 156331 can be formed by capture.
Research on fault detection and principal component analysis for spacecraft feature extraction based on kernel methods
Authors: Fu Na , Zhang Guanghua , Xia Keqiang , Qu Kun , Wu Guan , Han Minzhang , Duan Junru
Published: September 2022

Satellite anomaly is a process of evolution. Detecting this evolution and the underlying feature changes is critical to satellite health prediction, fault early warning, and response. Analyzing the correlation between telemetry parameters is more convincing than detecting single-point anomalies. In this article, principal component analysis method was adopted to downscale the multivariate probability model,

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statistic was checked to determine the data anomaly, without the trouble of threshold setting. After an anomaly was detected, time-domain visualization and dimension reduction methods were introduced to visualize the satellite anomaly evolution, where the dimensions of telemetry or features were reduced and presented in two- or three-dimensional coordinates. Engineering practice shows that this method facilitates the early detection of satellite anomalies, and helps ground operators to respond in the early stages of an anomaly.