bluuebunny/crossref_metadata_2025 huggingface dataset:
Social anxiety disorder among medical students in a tertiary care hospital in Davangere, Karnataka
Authors: D'souza Madonna J. , J. Arun Daniel , G. Muhammed Muntazeem
Published: March 2019

Background: Social anxiety disorder is a common psychiatric illness characterized by fear of being observed and scrutinized by others. It can impair academic performance and can lead to serious withdrawal from society and depression. The objective of the study was to measure the proportion and study the associated factors of Social Anxiety Disorder among students of a tertiary medical college and hospital.Methods: This hospital-based, cross-sectional study was conducted among the 272 medical students of a Tertiary care medical college and hospital at Davangere, Karnataka from October to December 2018. The social phobia inventory (SPIN) questionnaire was used to diagnose SAD among students.Results: Social anxiety disorder (SAD) was present among 30.5% (n=83) of the medical students. The female students (31.1%, n=45) documented a higher proportion of SAD compared to male students (29.9%, n=38). There was a higher incidence among above the 20 years age group and Muslims especially girl students.Conclusions: A higher proportion of medical students had social anxiety disorder which was influenced by increasing age, female gender, Muslim religion and higher academic years of exposure till final year.
Comparison of blood loss in endoscopic powered adenoidectomy and conventional curettage
Authors: Krishnakumar Nithya , Bashir N. K. , Raj Girish
Published: March 2019

Background: Adenoidectomy is one of the most common surgeries done in children. Over the years many techniques have evolved like powered adenoidectomy, radiofrequency ablation, electro cautery etc. Use of endoscopes has enabled surgeons to perform adenoidectomy under direct vision. The objectives of the study were to compare blood loss of conventional and endoscopic assisted powered adenoidectomy.

Methods: In this a prospective observational study of 30 children attending ENT department in MES Medical College was done. In the conventional technique, adenoidectomy was done using St Claire Thomson adenoid curette. In powered adenoidectomy technique, micro debrider was used under guidance of 00 nasal endoscope (2.7 mm). Intra operatively blood loss during surgery were looked for and noted in both groups.  

Results: In the study of 30 children divided in to 2 groups who are comparable statistically. Average blood loss in patients who underwent CA was 38.53 ml and in patients who underwent EAA was 28.27 ml, with standard deviation of 4.704 and 3.863 respectively. The difference in mean blood loss was 10.26 ml.

Conclusions: Endoscopic assisted powered adenoidectomy has lower blood loss as compared to conventional adenoidectomy.
Foveal Avascular Zone in Hypertension as Measured by Optical Coherence Tomography Angiography
Authors: De Sá Ludmila Gomes Dantas , Gadelha Diego Nery Benevides , Melo Maria Cecília Santos Cavalcanti , Brandt Carlos Teixeira
Published: March 2019

Purpose: To investigate the Foveal Avascular Zone (FAZ) area in patients with arterial hypertension using optical coherence tomography angiography (OCT-A).Material and methods: The study was permormed at the School Clinic of UNIFACISA and at the Eye Care Center. It was included 21 hypertensive patients (study group) and 19 individuals without hypertension (control group). It was excluded patientes with diabetes or glaucoma. The measurement of the FAZ areas was performed by the DRI OCT-1Triton/Plus. For the quantitative variables, the results were expressed by their means and standard deviations. Qualitative variables were expressed by their absolute and relative frequencies. Student’s t-test was used to verify differences between means and Fisher’s exact test for differences between frequencies. For evaluating the correlation between the superficial and deep plexus areas, the Pearson correlation test was used. P value ≤ 0.05, rejected the null hypothesis. The research was approved by the Ethics Committee of the Medical School from Campina Grande -UNIFACISA and all individuals signed the free and informed consent form.Results: The means of the superficial FAZ of both eyes was significantly higher in the study group (right eye 410.7 ± 160.7 μm2 - 319.1 ± 108.2 μm2 - p = 0.0433); (left eye: 405.4 ± 144.8 μm2 versus 309.4 ± 87.7 μm2- p = 0.0174). The means of the deep FAZ areas of the right and left eyes were similar between the study and control groups (right eye: 559.6 ± 253.28 μm2 versus 605.1 ± 226.8 μm2 - p = 0.5548); (left eye: 673.2 ± 170.8 μm2 versus 585.6 ± 171.2 μm2 - p = 0.1142). The relationships between the superficial and deep plexus areas of both eyes showed a weak correlation between the two plexuses. (r = 0.4734), left eye (r = 0.2287), study group - right eye: (r = 0.4374), left eye (r = 0.3580).Conclusion: The area of superficial FAZ of the right and left eyes was significantly higher in the hypertensive patients. The deep FAZ area of both eyes, however showed similar mean areas between the study and control groups.
Migrant teachers and classroom encounters: Processes of intercultural learning
Authors: Benson Alan
Published: March 2019

Recent migration combined with strategies to diversify the teacher workforce has led to complexities in teacher diversity identified by the term 'superdiversity' (Vertovec, 2006). This article builds on recent work on the processes of convergence and superdiversity (Wessendorf, 2011)
by focusing on meaningful encounters in the mathematics classroom. A sociolinguistics approach is used to discuss the performance of teacher identity, focusing on accent. An analysis of power shows tensions between Standard English and local vernaculars, involving microaggressions and opportunities
for intercultural learning. The article concludes by discussing coping with microaggressions and the systemic implications for school policies and initial teacher training. It shows how microaggressions offer opportunities for intercultural learning and how classroom spaces can be developed
that promote both this and the dispositions of an intercultural habitus.
AS AULAS DE EDUCAÇÃO FÍSICA NO GINÁSIO MONSENHOR MESSIAS EM ITABIRITO/MG, (1940 – 1948)
Authors: Galvão Gláucia Gonzaga , Oliveira Luzia Batista
Published: March 2019

A década de 1941, no Brasil, foi marcada por diversas mudanças nas leis relacionadas aos ensinos primário e secundário. O Ginásio Monsenhor Messias, Itabirito - MG, de turmas mistas, não tinha de um espaço apropriado para as atividades físicas. Como em todo o contexto nacional, também precisava adequar-se às novas leis. Com a finalidade de conhecer mais sobre as aulas de educação física, analisamos registros textuais e memória fotográfica e fragmentos presentes nos relatórios destinados ao Ministério da Educação e Cultura, tecidos pelo Inspetor Federal. Dialogamos com Souza (2001) sobre a leitura de imagens; com Schwartzman (2001) sobre as modificações da legislação do ensino secundário; com Oliveira e Chaves Júnior (2009) sobre o ensino secundário e as práticas esportivas e com Soares (2011) sobre a educação do corpo através do vestuário.
Conscientização: teoria e prática da libertação: uma introdução ao pensamento de Paulo Freire.
Authors: Borges Gabriela Fernanda Silva
Published: March 2019

O livro Conscientização: teoria e prática da libertação: uma introdução ao pensamento de Paulo Freire, escrito em 1979 por Paulo Freire, explica sobre o método de alfabetização dos camponeses iniciado em 1961, e expõe a importância do diálogo, do conhecimento ao contexto social, da criticidade, da práxis em busca da liberdade e da conscientização da sociedade marginalizada e oprimida pelas elites nos processos educativos. A obra está organizada em três partes, e para uma melhor compreensão foi destacado o essencial de cada uma destas partes, conservando os fundamentos filosóficos do autor.
AMBIÊNCIAS URBANAS: PERSONIFICAÇÃO DA CULTURA NO ESPAÇO PÚBLICO
Authors: Alarcon Santiago Acosta , Campos Juliano Bittencourt , Gonçalves Teresinha Maria
Published: March 2019

Este estudo procura resgatar a cultura ancestral indígena nas imagens da cidade na perspectiva da reconstrução da memória coletiva e a construção de uma linguagem significativa que possa contribuir para o fortalecimento da identidade de lugar. As ambiências urbanas relacionam-se aos espaços construídos e habitados da cidade, cujos mais significativos acredita-se que sejam os públicos, como os parques e as praças. O locus da pesquisa foi o maior e o mais frequentado parque de uma cidade do sul do Brasil. A pesquisa foi na modalidade qualitativa. Os aportes teóricos foram dados pela Psicologia Ambiental, Design Social e arqueologia o que originou uma proposta de mobiliário urbano.
FOTOGRAFIA COLONIAL: MATERIALIDADES E IMATERIALIDADES IDENTITÁRIAS NO CONTEXTO PORTUGUÊS
Authors: Rocha Liliana Oliveira da , Matos Patricia Ferraz de
Published: March 2019

O presente artigo reflete sobre o lugar da fotografia colonial no contexto patrimonial nacional português. Indagando sobre o modo como se processam os fenómenos de musealização, catalogação e atribuição de valor patrimonial a certos bens/objetos, explana-se sobre o que é legislado e institucionalizado por organismos do poder político, bem como sobre a sua influência na construção das narrativas identitárias e na patrimonialização dos legados coloniais. Com base nas resoluções legislativas, procura-se, assim, averiguar o que tem sido celebrado e salvaguardado em detrimento daquilo que tem sido apagado. Neste âmbito, dá-se particular atenção à fotografia, com o intuito de tentar perceber que futuro e que lugar poderão ter as imagens produzidas em contexto colonial nos museus nacionais.
Envelhecimento Populacional no Conselho Regional de Desenvolvimento do Litoral/RS e as implicações para as políticas públicas
Authors: Bitencourt Rossandra Oliveira Maciel de , Dalto Fabiano Abranches Silva
Published: March 2019

O objetivo geral deste trabalho consiste em analisar o processo de envelhecimento populacional nos municípios do Conselho Regional de Desenvolvimento do Litoral e seu potencial impacto sobre as políticas necessárias para o atendimento das demandas desse segmento. A metodologia utilizada foi um levantamento de dados junto ao Instituto Brasileiro de Geografia e Estatística (IBGE) e ao Programa das Nações Unidas para o Desenvolvimento (PNUD). A abordagem de análise foi quantitativa. No que se refere aos resultados, constatou-se inicialmente que no período de 2000-2010 esta foi a região do estado com maior destaque no aumento populacional. Com relação à população acima de 60 anos, este aumento foi de 75% superando as médias estadual e nacional. Por um lado, tem-se o aumento da população idosa nos balneários com pessoas provenientes de regiões metropolitanas do estado, que após a aposentadoria buscam um lugar tranquilo que propicie lazer e maior qualidade de vida. Por outro lado, nos municípios rurais verifica-se os fenômenos do êxodo juvenil, da masculinização e do envelhecimento do campo. Ou seja, embora os balneários apresentem expressivo aumento da população idosa por atrair aposentados, os municípios rurais destacam-se pelo intenso processo de envelhecimento daqueles que permanecem no campo. Em suma, os municípios precisam estar empenhados em atender as deliberações da Política Nacional do Idoso no que se refere à garantia de direitos e à inserção dos idosos no espaço público enquanto sujeitos sociais e coletivos. Os resultados desta pesquisa evidenciam que a população idosa do COREDE Litoral apresenta demandas segundo as especificidades de cada município, o que requer cautela na implementação de políticas públicas, pois estas não podem ser racionalmente planejadas para uma determinada categoria, englobando um universo de indivíduos que na prática não são homogêneos.Palavras-chave: Corede Litoral, Envelhecimento Populacional, Políticas Públicas
Análise Comparativa de Algoritmos de Mppt Bioinspirados nos Lobos Cinzentos Empregando um Sistema Fotovoltaico Conectado à Rede Elétrica Trifásica
Authors: Sampaio Leonardo P. , Rocha Maykon V. , Silva Sérgio A. O. da , Takami Marcelo H. F.
Published: March 2019

Este trabalho apresenta um sistema fotovoltaico (FV) trifásico de duplo estágio de conversão de energia conectado à rede elétrica, o qual é capaz de lidar com problemas de sombreamentos parciais em arranjos FV. Condições de sombreamentos parciais podem afetar o desempenho de sistemas FV, uma vez que as técnicas tradicionais de seguimento do ponto de máxima potência (MPPT – Maximum Power Point Tracking) podem operar em pontos de máximos locais de potência ao invés de máximos globais. Sendo assim, são apresentas quatro técnicas de MPPT bioinspiradas no método de otimização dos lobos cinzentos (GWO - Grey Wolf Optimization), as quais são capazes de extrair o ponto de máximo global de potência do sistema. Tais técnicas são denominadas neste trabalho como GWO, GWO-Beta, GWO-IC (Incremental Conductance) e GWO-P&O (Perturb and Observe). As referidas técnicas são avaliadas e comparadas uma com as outras empregando um sistema FV composto por um conversor CC/CC Boost e um inversor trifásico a três braços. Por meio de resultados de simulação e experimentais o desempenho e eficácia das quatro técnicas de MPPT são avaliadas levando em consideração o tempo de convergência, as oscilações de potência em regime permanente, assim como a eficiência na busca do ponto de máxima potência.
Parental Groups During Pregnancy and the Child's First Year: Swedish Parents' Experiences
Authors: Karlström Annika , Rising-Holmström Malin
Published: March 2019

The aim of the study was to assess parents' experience of parental support given before and after childbirth in a mid-Sweden region. A coherent education program implemented in a mid-Sweden region was evaluated. Data from two different samples of parents was collected through questionnaires. From the antenatal classes 563 women and men took part in the study. The other sample consisted of 176 parents from the child health care classes. The vast majority of parents from both groups were content with the sessions and their overall view was very positive. Both men and women felt strengthened before birth and in their parental role. New knowledge about breastfeeding and children's needs were gained. New thoughts about equal parenting and children's needs and development were achieved to a limited extent.
Peer Review Ensures Quality
Authors: Budin Wendy C.
Published: March 2019

In this column, the editor of The Journal of Perinatal Education (JPE) discusses the peer-review process utilized by JPE and why it is essential for quality. The editor also describes the contents of this issue, which offer a broad range of resources, research, and inspiration for childbirth educators in their efforts to promote, support, and protect natural, safe, and healthy birth.
Programa de Interc�mbio Internacional e a forma��o em enfermagem: A experi�ncia na Universidade do Minho, Braga/Portugal
Authors: Da Silva Nat�lia Cordeiro , Horta Nat�lia De C�ssia
Published: March 2019

Objetivo: discutir a experi�ncia de mobilidade acad�mica internacional, vivenciada na gradua��o em Enfermagem, bem como relacionar a forma��o e a pr�tica profissional experienciada. M�todo: trata-se de relato de experi�ncia vivenciado por acad�mica de Enfermagem da PUC Minas, na Universidade do Minho, em Portugal, por um per�odo de seis meses. Resultados: O interc�mbio contribuiu para aquisi��o de novos conhecimentos, trocas de experi�ncias e aproxima��o com a realidade da enfermagem em outras dimens�es, discutidas no artigo: Sistemas de sa�de brasileiro e portugu�s, Forma��o em Enfermagem e a Pr�tica do Cuidado de Enfermagem. Conclus�o: A inser��o em uma institui��o de excel�ncia no exterior agrega uma bagagem ampla e promove a expans�o e internacionaliza��o da ci�ncia e da inova��o t�cnico-cient�fica. Sendo assim, espera-se que o compartilhamento dessa viv�ncia sirva de incentivo para aqueles que buscam novas experi�ncias
Das imprevidentes baixas densidades à imprudente verticalização
Authors: Ficher Sylvia
Published: March 2019

Entre aqueles preceitos presentes na concepção original de Brasília que deixaram marcas profundas no seu posterior crescimento destaca-se a opção por baixas densidades. Desde sempre, a densificação populacional tem sido anátema, tanto mais denegrida quando associada a altas alturas nas edificações. As consequências são visíveis na dimensão desmesurada da mancha urbanizada do Distrito Federal. Contudo, o aumento crescente das distâncias e a elevação dos valores fundiários findaram por impor sua lógica nesta que já é a terceira metrópole brasileira. Hoje, está em curso um processo de acelerada verticalização justamente naquelas áreas menos capacitadas para suportar os impactos da nova massa edificada e do concomitante aumento populacional.
Origens da preservação de Brasília em debate: novas problematizações
Authors: Perpétuo Thiago Pereira
Published: March 2019

Os discursos que proporcionaram o reconhecimento de Brasília como patrimônio cultural atribuem ao passado sua legitimidade (como o Decreto nº 10,829/87 que, ao dispor sobre a preservação da cidade, anuncia estar regulamentando uma norma de 1960). Em face disso, o presente trabalho tem por objetivo analisar criticamente o que seriam as origens da preservação de Brasília: a solicitação do então presidente Juscelino Kubitschek para o tombamento precoce da cidade, no ano de sua inauguração; o artigo nº 38 da Lei San Tiago Dantas, que condicionava eventuais alterações no plano piloto de Lucio Costa a autorização do Senado Federal; e a proposta de criação de um Conselho para a preservação da cidade enquanto obra de arte. Pondero que as questões que emergem destes começos ou foram pouco exploradas pela bibliografia especializada ou o foram de modo a produzir mistificações a respeito de personagens e seus gestos. Assim, este texto busca revisitar tais estudos e investigar documentos da época, de modo a oferecer novos olhares e interpretações destes momentos basilares para o tombamento de Brasília, em que questões de ordem política se misturaram com decisões técnicas e proposições de preservação da Capital Federal como um objeto cultural.
Automated Analysis of X-Ray Images of the Temporomandibular Joint in Patients with Orthognathic Bite and Physiological Occlusion
Authors: Postnikov M. A. , Slesarev O. V. , Trunin D. A. , Andriyanov D. A. , Ispanova S. N.
Published: March 2019

Objective: to propose a procedure for analyzing the X-ray image of the temporomandibular joint (TMJ) through the automated calculation of linear and angular measurements from craniometry points in comparison with the reference values.

Material and methods. Fifty TMJ cone beam computed tomography images were analyzed in 25 volunteers aged 18-25 years with orthognathic bite and physiological occlusion. All the tomography images were analyzed from craniometric points, by using a section corresponding to the midsagittal plane of the TMJ. Angular and linear measurements characterizing the functional capacities of the TMJ were determined. A statistical analysis involved descriptive methods and was carried out by the IBM SPSS 21 statistics.

Results. The introduction of automated estimation of TMJ functional capacities from angular and linear measurements made it possible to obtain the following data: the α-angle was 11.99±2.44° for the right TMJ and 12.12±2.78° for the left one; the β-angle was 11.58±2.31° for the right TMJ and 12.42±2.81° for the left one; the γ-angle was 156.41±4.57° for the right TMJ and 155.46±5.50° for the left one. A descriptive statistics checking revealed no gross errors.

Conclusion. It is expedient to take into account the findings as reference values to characterize the anatomical and functional state of the TMJ on the x-ray image.
KÜRESEL GÜÇ MÜCADELESİ VE ULUS-DEVLETİN GELECEĞİ - GLOBAL POWER INSURANCE AND THE FUTURE OF THE NATION-STATE
Authors: ACAR Ünal
Published: March 2019

Tarihin her döneminde ekonomik gelişmeler kendi ideolojisini yaratarak siyasal değişimin de belirleyicisi olmuştur. Ulus devlet de uzun bir tarihsel süreç içinde, toplumsal ve ekonomik yapıların dönüşümü sonucunda ortaya çıkmıştır. Dolayısıyla ekonomik ve toplumsal yapıda yaşanan değişim ve dönüşümler yeni siyasal modelleri de tartışılır hale getirmiştir.

Günümüzde ekonomik, teknolojik vb alanlarda yaşanan değişimlerden beklenilen sonuçların alınabilmesi için stratejistler ulus devletlerin parçalanmasını öngören ideolojileri savunmaktadırlar. 1945'te 51 olan Birleşmiş Milletlere üye ülke sayısının 75 yıl sonra 200 olmasının bir nedeni de budur diyebiliriz. Devletini henüz kuramamış yaklaşık on beş bin ulus olduğunu dikkate aldığımızda, yirmi yıl sonra BM üye ülke sayısının ne kadar olacağını tahmin etmek kolay değildir. Küresel gelişmeleri değiştirme gücümüz olmadığına göre, önemli olan olayları doğru okuyabilecek ve ona göre önlemler alabilecek yapılanmaya gidebilmektir.

Küresel aktörler yeni bir dünya düzeni kurarken, kendi çıkarlarını gelişmekte olan ülkelerin çıkarları olarak sunarlar. Koydukları kurallara uymayanları ise terörist devlet ilan edip cezalandırırlar. Kurulmaya çalışılan yeni bir dünya düzeni olduğu için, bütün yöntemler uygulanmakta, bazı ülkeler askeri müdahale ile işgal edilmekte bazı ülkelerde ise iktidarlar renkli devrimlerle değiştirilmektedir.
FİNANSAL ORANLARIN PAY GETİRİLERİ ÜZERİNDEKİ ETKİSİNİN PANEL VERİ ANALİZİ: BİST 100 FİRMALARINDAN KANITLAR - PANEL DATA ANALYSIS OF THE EFFECT OF FINANCIAL RATIOS ON STOCK RETURNS: EVIDENCE FROM BIST 100 FIRMS
Authors: Isik Ozcan
Published: March 2019

Bu çalışmanın amacı, 2010-2017 döneminde Borsa İstanbul (BİST) 100 endeksi kapsamında sürekli faaliyet gösteren firmaların hisse senedi getirilerini etkileyen geleneksel finansal oranları belirlemektir. Çalışmada bağımsız değişken olarak kullanılan finansal oranlar sırasıyla borsa performans oranları, mali yapı oranları, karlılık oranları, faaliyet oranları ve likidite oranlarıdır. Panel veri regresyon analiz yönteminin uygulandığı çalışmadan elde edilen bulgulara göre, piyasa değeri defter değeri oranı, pay başına kazanç oranı, toplam borç oranı ve aktif getiri oranı gibi finansal oranlar pay getirilerindeki değişimi açıklamada istatistiksel olarak anlamlı bulunmuştur. Daha açık bir ifade ile pay senedi getirileri piyasa değeri defter değeri oranı, pay başına kazanç oranı, toplam borç oranı ve aktif getiri oranı ile pozitif yönde ilişkilidir.
TÜRKİYE’DE KAMU PERSONEL POLİTİKALARININ SÜREÇ MODELİ ÇERÇEVESİNDE ANALİZİ - AN ANALYSIS OF PUBLIC PERSONNEL POLICIES IN THE FRAMEWORK OF PROCESS MODEL IN TURKEY
Authors: ACAR Osman Kürşat , AKMAN Elvettin
Published: March 2019

Türkiye’nin kamu personel politikaları, çok sık değişen ve genellikle Türk siyasal hayatındaki darbeler, hükümet krizleri, ekonomik krizler gibi sorunlardan etkilenerek tepki politikaları olarak ortaya konulan, daha çok maliyeci bakış açısıyla üretilen, yerel dinamiklerden ziyade IMF, Dünya Bankası ve Avrupa Birliği gibi uluslararası ve ulus-üstü kuruluşların etkileri ile batılılaşma ekseninde oluşan politikalardır. Ayrıca mevzuat olarak kıta Avrupası’ndan ve konjonktürel olarak ABD ile İngiltere’den etkilenerek sürekli arayış içinde olan politikalar olduğunu da söylemek mümkündür. Cumhuriyetin ilk yıllarından 1960’lara kadar süren bu arayış çabaları, yetişmiş eleman eksikliği, dünya savaşları, ekonomik sebepler nedeniyle amacına ulaşmamıştır. 1960 sonrası 657 sayılı Devlet Memurları Kanunu ve Devlet Planlama Teşkilatı ile kurumsallaşma yönünde politikalar izlenmiş, fakat beklenilen başarı elde edilememiştir. 1980 sonrası kamu personel politikalarında ise yeni kamu yönetim ekseninde değişim çabaları başlamış, 2000 sonrası uygulama yönünde önemli adımlar atılmış ama yine başarılı sonuçlar elde edilememiştir. Son olarak 2018 yılı itibari ile Türkiye’de Cumhurbaşkanlığı Hükümet Sistemine geçilmesi ile birlikte bu arayış bugün için de farklı şekillerde devam etmektedir. Cumhurbaşkanlığı Hükümet Sisteminde Cumhurbaşkanlığı Makamı altında “İnsan Kaynakları Ofisi”, İdari İşler Başkanlığına bağlı “Personel ve Prensipler Genel Müdürlüğü” ve “Strateji ve Bütçe Başkanlığı” kurulmuştur. Ayrıca Devlet Personel Başkanlığının 2019 Temmuz ayı itibari ile kapatılmasıyla birlikte yetki, görev ve sorumluluklarının çoğu Çalışma, Sosyal Hizmetler ve Aile Bakanlığına devredilecektir. Bu çalışma ile Türkiye’de Cumhuriyet tarihi boyunca üretilen kamu personel politikalarını gündeme gelmesi, formüle edilerek yasalaşması, uygulanması, geri bildirim ve denetim aşamaları kamu politikası analiz modellerinden birisi olan süreç modeli ile analiz edilmiştir. Böylece Cumhurbaşkanlığı Hükümet Sistemine kadar olan dönemde kamu personel politikalarının oluşturulma, uygulama ve denetim süreci detaylıca ortaya konulmuştur. Ayrıca Cumhurbaşkanlığı Hükümet Sistemi çerçevesinde kurulan yeni yapıya ilişkin öneriler geliştirilmiştir.
Ligand-Protein Interactions: A Hybrid ab initio/Molecular Mechanics Computational Study
Authors: Perez Yornei R. , Alvarez Dinais , Combariza Aldo
Published: March 2019

Cyclooxygenases (COX), or prostaglandin endoperoxide synthases (PTGS), are key enzimes in the synthesis of prostaglandins, which are chemical species critical in mediating inflammatory processes. There are two highly homologous COX isoforms: COX-1 and COX-2. COX-1 is involved in the production of prostaglandins, chemical compuounds that take part in physiological processes such as: protection of the gastric epithelium, maintenance of renal flow, platelet aggregation, neutrophil migration and, also, are expressed in the vascular endothelium. Meanwhile, COX-2 is induced by proinflammatory stimuli. It is very frequent the use of nonsteroidal antiinflammatory drugs (NSAIDs) to counteract the symptoms of inflammatory processes. These drugs, in addition to its benefits, can cause side effects on people’s health, such as cardiovascular and respiratory problems, among others. In the past years, it has been recognized the potential of plants secondary metabolites as pharmacological agents, prompting the need for investigations that shed light into its mechanism of action. In this work we have applied computational techniques, based on quantum chemistry and mechanical statistics, to study the protein-ligand interaction involving COX’s and secondary metabolites from natural sources. Our aim is to determine the structure activity interplay in processes involving the participation of secondary plant metabolites such as luteolin, galangin, kaempferol, apigenin, morine and quercetin on the inactivation of COX’s. From molecular docking analysis, we have extracted the energetics of the COX-(1,2)/metabolite coupling. By defining energy based factors, we have determined a procedure that predicts the chemical species with highest stability and selectivity towards inactivation of COX-2 over COX-1. The results are discussed with regard to conformational features of the selected ligands and its intermolecular strong/weak interactions inside the active-sites of the COX’s hosts.
Modern Methods for Aircraft Power and Propulsion
Authors: Petrescu Relly Victoria , Aversa Raffaella , Apicella Antonio , Petrescu Florian Ion Tiberiu
Published: March 2019

Even though the current classic aerospace propulsion methods are greatly improved, some of the most modern methods have already been introduced, among which the propulsion with electric motors. Energy can be obtained from hydrogen burners, honeycomb burners to protect the burning of hydrogen that burns 10 times faster than conventional oil fuels or alcohols. Hydrogen storage is also done in honeycomb cell reservoirs. Getting solar photovoltaic power even during flight is not yet profitable or efficient, but it can be proposed in the future for lighter and/or spacecraft. A great desire is to dismantle water in hydrogen and oxygen directly on the aircraft, so the stored fuel is actually water and the one actually used is the hydrogen removed from the water. In this case, there is no need for hydrogen storage. And other modern methods of propulsion and energy acquisition are briefly presented in the paper.
Insights into Actin-Myosin Interactions within Muscle from 3-D Electron Microscopy
Authors: Taylor Kenneth A. , Ramani Hamidreza , Edwards Robert J. , Reedy Michael K.
Published: March 2019

Much has been learned about the interaction between myosin and actin through biochemistry, in vitro motility assays and cryo-electron microscopy of F-actin decorated with myosin heads. Comparatively less is known about actin-myosin interactions within the filament lattice of muscle, where myosin heads function as independent force generators and thus most measurements report an average signal from multiple biochemical and mechanical states. All of the 3-D imaging by electron microscopy that has revealed the interplay of the regular array of actin subunits and myosin heads within the filament lattice has been accomplished using the flight muscle of the large waterbug Lethocerus sp. Lethocerus flight muscle possesses a particularly favorable filament arrangement that enables all the myosin cross-bridges contacting the actin filament to be visualized in a thin section. This review covers the history of this effort and the progress toward visualizing the complex set of conformational changes that myosin heads make when binding to actin in several static states as well as fast frozen actively contracting muscle. The efforts have revealed a consistent pattern of changes to the myosin head structures determined by X-ray crystallography needed to explain the structure of the different acto-myosin interactions observed in situ.
Complexity and entanglement for thermofield double states
Authors: Chapman Shira , Eisert Jens , Hackl Lucas , Heller Michal P. , Jefferson Ro , Marrochio Hugo , Myers Robert C.
Published: March 2019

Motivated by holographic complexity proposals as novel probes of
black hole spacetimes, we explore circuit complexity for thermofield
double (TFD) states in free scalar quantum field theories using the
Nielsen approach. For TFD states at t = 0t=0,
we show that the complexity of formation is proportional to the
thermodynamic entropy, in qualitative agreement with holographic
complexity proposals. For TFD states at t>0t>0,
we demonstrate that the complexity evolves in time and saturates after a
time of the order of the inverse temperature. The latter feature, which
is in contrast with the results of holographic proposals, is due to the
Gaussian nature of the TFD state of the free bosonic QFT. A novel
technical aspect of our work is framing complexity calculations in the
language of covariance matrices and the associated symplectic
transformations, which provide a natural language for dealing with
Gaussian states. Furthermore, for free QFTs in 1+1 dimension, we compare
the dynamics of circuit complexity with the time dependence of the
entanglement entropy for simple bipartitions of TFDs. We relate our
results for the entanglement entropy to previous studies on
non-equilibrium entanglement evolution following quenches. We also
present a new analytic derivation of a logarithmic contribution due to
the zero momentum mode in the limit of vanishing mass for a subsystem
containing a single degree of freedom on each side of the TFD and argue
why a similar logarithmic growth should be present for larger
subsystems.
The role of knowledge management in organizational performance: case study of University of Malang, Indonesia
Authors: Nu Graha Andi , Sudiro Achmad , Armanu  , Ratnawati Kusuma
Published: March 2019

The present study puts forward a model that examines variables of human resources management practices, organizational culture, knowledge management and organizational performance. By this model, it intends to explore the effects of human resources management practices and organizational culture on organizational performance. Particularly, it intends to find out their relationship with knowledge management as a mediator. The research applies SmartPLS for data analysis, with 163 respondents by means of saturation sampling technique. The results display several facts. First, both HRD practices and organizational culture have significant effects on knowledge management. Second, while knowledge management and organizational culture have a significant effect on organizational performance, HRD practices do not significantly affect organizational performance. It makes knowledge management only serve a partial mediation between human resources management practices and organizational performance, and serve a full mediation between organizational culture and organizational performance.
Kemiskinan dalam Perspektif Sosiologi
Authors: Wardaya Sulistya , Suprapti Anni
Published: March 2019

This paper describes the social and cultural situation of Pematang Gubernur Village, Muara Bangka Hulu Sub-district, Bengkulu City. Formerly, this area belongs to Suku Lembak who lived in Tanjung Agung and Tanjung Jaya village. The population of Pematang Gubernur has increased along with the establishment of Bengkulu University housing and the relocation of government office of Bengkulu City to Muara Bangka Hulu Sub-district. Based on the sociological analysis, Suku Lembak becomes a minority group in their own territory and as a minority, they are no longer able to carry out their customs and traditions, in contrast, the migrants that have become majority group, in fact, can apply their traditions and rituals from their origin. This research found that the social structure of Pematang Gubernur Village is seeking its ideal format. The community of the village is diverse and live in different groups based on housing complex and kampong. This makes the community divided and trapped in the situation in which the interaction between groups is limited. This also makes the community of Padang Gubernur has a narrow perspective in understanding poverty by seeing it as merely a problem of success and failure in pursuing the career and business of their neighbors. They also have narrow self-orientation and non-competitive capacities.
Axial dispersion in aeration tanks
Authors: Murphy Keith L. , Timpany Peter L.
Published: March 2019

The primary function of an aeration tank is to provide sufficient time, and a suitable environment for the assimilation of organics by micro-organisms. Initally assimilation occurs by a rapid absorption or adsorption process. After this initial contact-phenomena between the waste and micro-organisms, the biochemical reactions predominate, but at a decreased rate of organic removal. In any event the extent of treatment may be related to the retention period in the aerator.
Kinetics of Biological Oxidation
Authors: Jank B.E. , Drynan W.R.
Published: March 2019

The future development of the activated sludge process depends to a large extent upon a basic understanding of the kinetics of the biological processes involved and an evaluation of the effects of various factors on these kinetics. A realistic evaluation of the effects of such variables as influent quality and quantity, presence of toxic materials, shock loads, sludge age, pH, etc., on the activated sludge process can be made only if the kinetics of biological oxidation are well defined and reproducible under normal conditions. In addition, a knowledge of the kinetics for a given waste and sludge, particularly in the case of industrial wastes, should provide a more meaningful approach to process design.
Physical Activity as a Moderator of Alzheimer Pathology: A Systematic Review of Observational Studies
Authors: Frederiksen Kristian Steen , Gjerum Le , Waldemar Gunhild , Hasselbalch Steen Gregers
Published: March 2019

Introduction:

Observational studies have found that physical activity is associated with a
reduced risk of cognitive decline and dementia. Whether physical activity may also reduce the level of
AD pathology, remains undetermined.

Objective:

To examine the relationship between physical activity and AD biomarkers (beta-amyloid1-
42, total tau and phosphorylated tau in CSF, amyloid PET, hippocampal atrophy on MRI and parietotemporal
hypometabolism on brain 18F-FDG-PET).

Methods:

We carried out a systematic review of the observational studies of physical activity and AD
biomarkers in healthy subjects, subjective cognitive complaints, mild cognitive impairment (MCI) and
AD dementia.

Results:

We identified a total of 40 papers, which were eligible for inclusion. Thirty-four studies were
conducted on healthy subjects, 3 on MCI and healthy subjects, 1 on MCI, and 2 on AD and healthy
controls. Six studies reported on CSF biomarkers, 9 on amyloid PET, 29 on MRI and 4 on brain 18FFDG-
PET. The majority of studies did not find a significant association between physical activity and
AD biomarkers

Conclusion:

The quality of included studies with only a few longitudinal studies, limits the conclusions
which may be drawn from the present findings especially regarding the biomarkers other than hippocampal
volume. However, the majority of the identified studies did not find a significant association.
Effects of Vitamin D Status on Inflammatory Markers in Obese Subjects: A Systematic Review
Authors: de Alencar Geórgia R.R. , da Silva Freire Lailton , de Mello Pereira Beatriz , da Silva Verbena R. , Holanda Aline C. , de Moura Rayane C. , Severo Juliana S. , Braz Debora C. , Marreiro Dilina do Nascimento , de Jesus e Silva de Almendra Freitas Betânia , de Carvalho Cecília M.R.G.
Published: March 2019

Background:

Recent studies have demonstrated the role of micronutrients in the manifestation
of comorbidities associated with obesity. Vitamin D deficiency, in particular, appears to be associated
with increased levels of inflammatory markers, which may lead to chronic low-grade inflammation,
elevating the risk of chronic diseases such as diabetes, metabolic syndrome, and cardiovascular
disease. The objective of this study was to perform a systematic review of observational
studies conducted to investigate the effect of vitamin D deficiency on inflammatory markers in obese
subjects.

Methodology:

This systematic review was conducted in accordance with the “STROBE” and PRISMA
recommendations. Observational studies that evaluated the effect of vitamin D status on inflammatory
markers in obese subjects were selected and reviewed. Searches were conducted in the
PubMed, SciVerse Scopus, and Web of Science databases from February 21 to 22, 2018.

Results:

After the selection and removal of duplicate articles, 10 eligible articles were identified. Results
from eight observational studies showed an association between vitamin D deficiency or insufficiency
in the body and increased concentrations of inflammatory markers in obese individuals. On
the other hand, two of the studies did not demonstrate any correlation. With regard to the inflammatory
markers evaluated, eight studies showed high concentrations of ultra-sensitive C-reactive protein,
five studies found an increase in interleukin-6 concentrations, and two studies noted increased
levels of tumor necrosis factor.

Conclusion:

The data presented in this systematic review provide evidence of the association between
vitamin D deficiency and increased inflammation in obesity.
Herbal Detoxifiers: An Eminent Need of Today
Authors: Pal Rashmi S. , Pal Yogendra , Wal Ankita , Wal Pranay
Published: March 2019

Ranging from the skin to liver, body has an in-built detox system that keeps it running
smoothly on a daily basis. Due to the present life-style, increased stress, pollution, unhealthy dietary
habits, the natural system gets weakened. The need of present time is to unveil the herbs present in
the nature full of detox potential, inheriting the capacity to purify the kidney, liver, gut, skin and
blood. These herbal detoxifiers facilitate lungs, aids kidneys, facilitates digestive tract and skin. The
present review deals with the study of herbs under the category of detoxifiers for kidney, liver, gut,
skin and blood. The herbs were studied by sectioning them for their detoxification potential for the
major organs of the body. The use of herbal agents to detox the major organs of the body not only
helps to remove the toxins but also increases the overall energy and efficiency of the body.
Awareness, knowledge, perceived benefits, and barriers regarding precision medicine and willingness to participate in a national registry: Comparison of cancer patients and the general population (Preprint)
Authors: Lee Mangyeong , Cho Juhee , Kong Sun-Young , Yoon JunghHee , Kang Danbee , Choi Kui Son , Shin Soo-Yong , Seo Hwa Jeong , Jung So-Youn , Lim Myong Cheol , Lee Eun Sook , Chang Yoon Jung
Published: March 2019

BACKGROUND

Precision medicine (PM) is a growing area of interest in cancer care. Although the terms ‘precision medicine’ and ‘personalized medicine’ are used interchangeably, the former may be new both to cancer patients and the general population. Most previous studies evaluated peoples’ attitudes towards genetic testing as a part of personalized medicine and included a single stakeholder, either patients or the general population. Few studies have evaluated cancer patients’ knowledge and perception regarding PM.

OBJECTIVE

To evaluate cancer patients’ awareness, knowledge, as well as perceived benefits and barriers regarding PM, and their willingness to participate in a national registry for PM, in comparison to those of the general population.

METHODS

We conducted a cross-sectional survey on 1,500 consecutive cancer patients enrolled at two university-based cancer hospitals in Seoul, Korea; 1,500 people who were representative of the Korean population were enrolled as controls. Multivariable logistic regression was conducted to identify the factors associated with a willingness to participate in a national registry for PM.

RESULTS

: In the total population, 20.0% of the cancer patients had heard of PM and 35.1% were able to accurately define it. Cancer patients were three times likelier to express a willingness to participate in a national registry for PM than the general population (95% confidence interval [CI], 2.47-3.61). Participants who had heard of PM (cancer patients: adjusted odds ratio (aOR) = 1.40, 95% CI, 1.00-1.95; general population: aOR = 2.04, 95% CI, 1.62-2.56) and who had a more positive perception of the PM-related benefits (cancer patients: aOR = 2.48, 95% CI, 1.88-3.27; general population: aOR = 1.34, 95% CI, 1.05-1.71) were likelier to be willing to participate in a national registry for PM.

CONCLUSIONS

While PM is gaining importance in clinical settings, a majority of cancer patients are not well-informed about it. Nevertheless, the patients in our study perceived PM as being associated with various benefits and showed a willingness to participate in a national registry for PM. Considerable efforts need to be taken to educate the public and advocate participation in studies on PM
Older People with Type 2 diabetes - Individualising Management wIth a SpecialisEd community team: Safety and feasibility study (OPTIMISES): protocol (Preprint)
Authors: Ogrin Rajna , Neoh Sandra , Aylen Tracy , Audehm Ralph , Churilov Leonid , Thurgood Lorenna , Major Georgia , Zajac Jeffrey , Ekinci Elif I
Published: March 2019

BACKGROUND

The prevalence of diabetes is rising in older people. Clinical guidelines recommend that diabetes management should be individualised, however, there is limited information regarding the current management patterns of diabetes in older people. Few individuals achieve optimal glycaemic levels in the general population which could potentially lead to adverse health outcomes and impact quality of life.

OBJECTIVE

To trial individualised diabetes management intervention for older people through home visits with a credentialed diabetes educator and telehealth consultations with an endocrinologist located at a tertiary hospital.

METHODS

This paper describes the design and methodology of a mixed methods feasibility and safety study to identify the current management of people 65 years or older with type 2 diabetes. We will implement and evaluate a personalised approach to management in the community of an Australian metropolitan city. This management approach will utilise flash glucose monitoring and home visits with the support of a community home nursing service credentialed diabetes educator and telehealth consultation with an endocrinologist located at a local tertiary hospital.

RESULTS

Not reported

CONCLUSIONS

This study is the first of its kind to explore individualised diabetes management for community dwelling older people, aimed to achieve optimal glycaemic levels. The data drawn from this project may be used to inform policy makers, service providers, clinicians and older adults living with diabetes.

CLINICALTRIAL

Australian Clinical Trial Registration: ACTRN12617000350325
Behavioral, Nutritional, and Genetic Risk Factors of Colorectal Cancers in Morocco: Protocol for a Multicenter Case-Control Study (Preprint)
Authors: Mint Sidi Ould Deoula Meimouna , Huybrechts Inge , El Kinany Khaoula , Boudouaya Hanae , Hatime Zineb , El Asri Achraf , Benslimane Abdelilah , Nejjari Chakib , Sidi Adil Ibrahimi , El Rhazi Karima
Published: March 2019

BACKGROUND

Colorectal cancer (CRC) has been reported as the third most commonly diagnosed cancer worldwide and is currently considered as a major public health concern. A peak increase in incidence has been noted in economically transitioning countries like Morocco where industrialization started shifting from a traditional lifestyle and diet toward a more westernized diet and lifestyle.

OBJECTIVE

This paper aims to present the protocol of a large-scale Moroccan case-control study that aims at investigating associations of diet, other lifestyle factors, and genetic traits with CRC risk in Morocco.

METHODS

A case-control study was conducted between 2009 and 2017, including 3032 case-control pairs (1516 cases and 1516 controls) matched on sex, age, and center in 5 major public health hospitals in Morocco. Questionnaires on sociodemographic data, lifestyle, family history of CRC, and nonsteroidal anti-inflammatory drugs (NSAIDs) were completed by trained investigators during face-to-face interviews. In addition, participants completed a semiquantitative food-frequency questionnaire, developed to assess food intake in the Moroccan population. Information regarding genetic factors was recorded for cases, and paraffin blocks (with embedded tumor tissues) are available in 3 collaborating hospitals. Conditional logistic regression analysis is planned to assess associations between diet and CRC risk. Binary logistic regression is considered to predict associations between mutations and nutritional risk factors including only CRC case series.

RESULTS

Altogether, 2966 cases-control pairs (1483 cases and 1483 controls) were considered eligible and included in this study. Both cases and controls did not differ significantly with respect to age (P=.36), sex (P=.51), center (P>.99), marital status (P=.30), and NSAID use (P=.08). However, participants in the control group were significantly more likely to have a high income level and live in urban areas and to have a high level of education than cases.

CONCLUSIONS

This is the first study investigating potential risk factors of CRC such as lifestyle, diet, and genetic factors, originating from a southern Mediterranean country with low but increasing CRC prevalence. Identified risk factors allow the establishment of evidence-based preventive actions regarding nutrition and other lifestyle habits adapted to the Moroccan context. In brief, this study will promote cancer research and prevention in Morocco.

INTERNATIONAL REGISTERED REPORT

RR1-10.2196/13998