bluuebunny/crossref_metadata_2025 huggingface dataset:
Regio- and Chemoselective Double Allylic Substitution of Alkenyl vic-Diols
Authors: Chen Bocheng , Pagès Lucas , Dollet Raphaël , Kouklovsky Cyrille , Prévost Sébastien , de la Torre Aurélien
Published: December 2023

Double allylic substitution is an attractive approach to build molecular complexity from simple starting materials by creating two new bonds in one-pot. However, this type of reaction has been doomed by chemoselectivity and regioselectivity issues. In this manuscript, we describe a new approach to introduce a-la-carte two new C–C, C–N, C–O or C–S bonds in a chemo- and regioselective fashion. The reaction relies on sequential dual catalysis with Lewis acid and palladium. The scope is remarkably broad, and the reaction can be diastereoselective using secondary alcohols as the first nucleophile.
Controlling neural network extrapolation enables efficient and comprehensive sampling of coverage effects in catalysis
Authors: Schwalbe-Koda Daniel , Govindarajan Nitish , Varley Joel
Published: December 2023

Sampling high-coverage configurations and predicting adsorbate-adsorbate interactions on surfaces are highly relevant to understand realistic interfaces in heterogeneous catalysis. However, the combinatorial explosion in the number of adsorbate configurations among diverse site environments presents a considerable challenge in accurately estimating these interactions. Here, we propose a strategy combining high-throughput simulation pipelines and a neural network-based model with the MACE architecture to increase sampling efficiency and speed. By training the models on unrelaxed structures and energies, which can be quickly obtained from single-point DFT calculations, we achieve excellent performance for both in-domain and out-of-domain predictions, including extrapolation to different facets, coverage regimes and low-energy configurations. From this systematic understanding of model robustness, we exhaustively sample the configuration phase space of catalytic systems without false positives or active learning. In particular, by evaluating over 14 million structures within the simulated annealing method, we predict coverage-dependent adsorption energies for CO adsorption on six Cu facets (111, 100, 211, 331, 410 and 711) and the co-adsorption of CO and CHOH on Rh(111). When validated by targeted post-sampling relaxations, our results for CO on Cu correctly reproduce experimental interaction energies reported in the literature, and provide atomistic insights on the site occupancy of steps and terraces for the six facets at all coverage regimes. Additionally, the arrangement of CO on the Rh(111) surface is demonstrated to substantially impact the activation barriers for the CHOH bond scission, illustrating the importance of comprehensive sampling on reaction kinetics. Our findings demonstrate that simplified data generation routines and controlled extrapolation of neural networks can be deployed at scale to understand lateral interactions on surfaces, paving the way towards realistic modeling of heterogeneous catalytic processes.
Acyl phosphates as chemically fueled building blocks for self-sustaining protocells.
Authors: Zozulia Oleksii , Kriebisch Kriebisch , Kriebisch Brigitte , Soria Carrera Héctor , Rici Ryadi Kingu , Steck Juliana , Boekhoven Job
Published: December 2023

Lipids can spontaneously assemble into vesicle-forming membranes. Such vesicles serve as compartments for even the simplest living systems. Vesicles have been extensively studied for constructing synthetic cells or as models for protocells—the cells hypothesized to have existed before life. These compartments exist almost always close to equilibrium. Life, however, exists out of equilibrium. In this work, we studied vesicle-based compartments regulated by a non-equilibrium chemical reaction network that converts activating agents. Specifically, we use activating agents to condense carboxylates and phosphate esters into acylphosphate-based lipids that form vesicles. These vesicles can only be sustained when condensing agents are present, and without them, they decay. We demonstrate that the chemical reaction network can operate on prebiotic activating agents, opening the door to prebiotically plausible, self-sustainable protocells that compete for resources. In future work, such protocells should be endowed with a genotype, for example, based on self-replicating RNA structures that affect the protocell behavior to enable Darwinian evolution in a prebiotically plausible chemical system.
Thermal vs. Visible-Light Photoredox-Catalyzed Cascade Radical Cyclization Involving SO2 Fixation to Access 6-Alkylsulfonylmethyl Phenanthridines
Authors: Sahu Tonish Kumar , Vishwakarma Abhay Kumar , Kumar Vidyanshu , Khan Rahimuddin , Khan Tabrez
Published: December 2023

Convenient access to 6-alkylsulfonylmethyl phenanthridines has been demonstrated both under thermal and visible-light photoredox-catalyzed conditions. A cascade of radical cyclization is triggered on exposure of biphenyl vinyl azides to the in-situ generated alkyl sulfonyl radicals from 4-substituted Hanztsch esters in the presence of an SO2 surrogate. Transition metal-free, mild reaction conditions, and broad substrate scope constitute some of the highlights of the approach. Also, the synthetic utility of the accessed 6-alkylsulfonylmethyl phenanthridines has been demonstrated.
Shear-Induced Cyclo-Reversion Leading to Shear-Thinning and Autonomous Self-Healing in an Injectable, Shape-Holding Collagen Hydrogel
Authors: Jamadi Khiabani Mahsa , Soroushzadeh Sareh , Talebi Ardeshir , Samanta Ayan
Published: December 2023

In vivo injectable extracellular matrix (ECM) derived hydrogel that is suitable for cell encapsulation has always been the holy grail in tissue engineering. Nevertheless, these hydrogels still fall short today of meeting three crucial criteria: flexibility on the injectability time-window, autonomous self-healing of the injected hydrogel, and shape-retention under aqueous conditions. Here we report the development of a collagen-based injectable hydrogel, crosslinked by cycloaddition reaction between furan and maleimide groups, that is injectable up to 48 hours after preparation and can undergo complete autonomous self-healing after injection. Furthermore, this hydrogel can retain its shape and size over several years when stored in buffer, yet can be degraded within hours when treated with collagenase. The biocompatibility of this hydrogel was demonstrated in vitro by cell-culture and in vivo by subcutaneous implantation in rats.
Site-Specific Antibody Prodrugs via S-Arylation: A Bioconjugation Approach Toward Masked Tyrosine Analogues
Authors: Tao Jason , Dhanjee Heemal H. , Gribble Jr. Michael W. , Kottisch Veronika , Rodriguez Jacob , Brown Joseph S. , Schmidt Holly , Juneja Juhi , Denhez Fabienne , Lee Peter , Lipovšek Daša , Krystek Stanley , Zhang Yihong , Bousquet Patrick , Zhang Yong , Pentelute Bradley L. , Buchwald Stephen L.
Published: December 2023

The utility of antibody therapeutics is hampered by potential cross-reactivity with healthy tissue. Over the past decade, significant advances have been made in the design of activatable antibodies which increase, or create altogether, the therapeutic window of a parent antibody. Of these, antibody prodrugs (pro-antibodies) are masked antibodies that have advanced the most for therapeutic use. They are designed to reveal the active, parent antibody only when encountering proteases upregulated in the microenvironment of the targeted disease tissue, thereby minimizing off-target activity. However, current pro-antibody designs are relegated to fusion proteins that append masking groups restricted to the use of only canonical amino acids, offering excellent control of the site of introduction, but with no authority over where the masking group is installed other than the N-terminus of the antibody. Here, we present a palladium-based bioconjugation approach for the site-specific introduction of a masked tyrosine mimic in the complementary determining region of the FDA approved antibody therapeutic Ipilimumab used as a model system. The approach enables the introduction of a protease cleavable group tethered to non-canonical polymers (poly-ethylene glycol, PEG) resulting in 47-fold weaker binding to cells expressing CTLA-4, the target antigen of Ipilimumab. Upon exposure to tumor-associated proteases, the masking group is cleaved unveiling a tyrosine-mimic (dubbed a hydroxyphenyl cysteine, HPC) that restores (>90% restoration) binding affinity to its target antigen.
Guided docking as a data generation approach facilitates structure-based machine learning on kinases
Authors: Backenköhler Michael , Groß Joschka , Wolf Verena , Volkamer Andrea
Published: December 2023

Drug discovery pipelines nowadays rely on machine learning models to explore and evaluate large chemical spaces. While including 3D structural information is considered beneficial, structural models are hindered by the availability of protein-ligand complex structures. Exemplified for kinase drug discovery, we address this issue by generating kinase-ligand complex data using template docking for the kinase compound subset of available ChEMBL assay data. To evaluate the benefit of the created complex data, we use it to train a structure-based E(3)-invariant graph neural network (GNN). Our evaluation shows that binding affinities can be predicted with significantly higher precision by models that take synthetic binding poses into account compared to ligand or DTI models only.
A DSGE Model Including Trend Information and Regime Switching at the ZLB
Authors: Gelain Paolo , Lopez Pierlauro
Published: December 2023

This paper outlines the dynamic stochastic general equilibrium (DSGE) model developed at the Federal Reserve Bank of Cleveland as part of the suite of models used for forecasting and policy analysis by Cleveland Fed researchers, which we have nicknamed CLEMENTINE (CLeveland Equilibrium ModEl iNcluding Trend INformation and the Effective lower bound). This document adopts a practitioner's guide approach, detailing the construction of the model and offering practical guidance on its use as a policy tool designed to support decision-making through forecasting exercises and policy counterfactuals.
Features of Professional Training of Specialists in the field of Public Governance and Administration
Authors: Derun Tetyana
Published: December 2023

The article considers the issues of professional training of specialists in the field of public administration. The specifics of public administration are studied. It is determined that the purpose of professional training of specialists in the field of public administration is the formation and development of a new generation of specialists in public administration. The provisions of the standard of higher education in the specialty 281 «Public Administration» for the first (bachelor’s) and second (master’s) level of higher education are studied. It is established that in order to increase the efficiency and quality of professional training of specialists in the field of public administration and administration, it is expedient to orient students to choose the specialization that will best meet their expectations regarding future employment. The importance of competencies in ensuring the successful work of future specialists in the field of public administration is justified.The American experience of training specialists in the field of public administration, in particular on the formation of professional competencies, is studied. It was found that in American educational institutions, along with the main disciplines and elective courses that students choose depending on their future specialization, in-depth courses are taught in the most relevant areas (spheres) in public policy-making.The program results of training of future specialists in the field of public administration are given. It is substantiated that the experience of the school of public administration in the United States is based on the introduction of modern trends in public administration, styles of administration, creative thinking, new information technology capabilities, rethinking the requirements for professional and personal qualities of public servants.It is expedient to improve the standard of higher specialty 281 «Public Administration» in order to balance professional competencies, their consistency with the needs of public administration, as well as review educational and professional programs and curricula containing a list of disciplines that provide different competencies.
Components of Public Policy in the Conditions of Implementation of the Mobilization Model of Economic Development
Authors: Kovalenko Mykola , Dunayev Igor
Published: December 2023

The article examines aspects of public policy formation with the aim of implementing the mobilization model of economic development. Threats and challenges to Ukraine’s national security under martial law indicate about the need for fundamental changes in approaches to the formation of the foundations of public policy aimed at a deep transformation of economic relations. Public policy can become a means of overcoming disputes in society and contribute to the establishment of an order that is recognized by all members of society. And the extent to which public policy takes care of the interests and needs of the common people, or defends transnational, oligarchic, state-bureaucratic, party, confessional, or any other corporate interests, will depend on the actual degree of its publicity and the effectiveness of confronting modern challenges and threats. The main concepts of ensuring the economic security of the state and accelerating its economic development are considered. For the effective functioning of the mobilization model of economic development, there is a need to centralize the state administration system with a strengthening of the role of planning, organization, regulation and control.
Economic security is achieved in the presence of the necessary norms, appropriate public policy, an effective mechanism of state administration, effective institutions for the protection of the public interest, and coordination of the activities of political and public forces. The economy of the state should always be aimed at achieving specific social goals, the basis of which is a person, various components of his comprehensive development, his rights, the opportunity to live and work peacefully, cooperation and a fair system. The mobilization model of economic development is meant as an anti-crisis model of the economy, aimed at maximum protection of the state from various threats and challenges, which is based on a special system of public management of economic activity, which allows to ensure the fullest use and restoration of production factors. Only the state can carry out the necessary mobilization of the economy for the benefit of society, taking into account the interests of future generations. Business itself is not capable of this. The work raises the question of fundamental reform of economic relations, overcoming the consequences of economic degradation in the conditions of the arbitrariness of the colonial-oligarchic model of the economy, changing the vector of the country’s socio-economic development in the direction of ensuring economic, technological, digital, cultural and educational sovereignty. According to the results of these processes, not only the management system and the economy must change, people must change, the state itself must change.
Toolkit for Performing Public Control of Compliance with Labor Legislation
Authors: Pavlovskiy Ruslan
Published: December 2023

In the article, through scientific abstraction, the concept of public control tools is defined as a set of means for realizing the goal of ensuring the rights, freedoms, and legitimate interests of individual citizens and society as a whole, which is carried out by public organizations, associations, and the population. Adapting the tools of control used in the management of organizations to the field of labor protection, it can be argued that public control in the field of labor protection can be carried out according to the legality of wage calculations, for which financial control tools can be used; part of the operational control tools can be involved in monitoring compliance with safety techniques at enterprises; individual quality control tools can be used in compliance with social labor conditions.
The toolkit of public control over compliance with labor legislation can be selected depending on the purpose of its implementation. The purpose of control may change, and depending on it, one or another toolkit is selected, it may be more extensive, or only certain tools may be used. Even when the purpose of control is the same, the individual tasks resulting from it, and accordingly, the tools, may differ. The results of public control may be demands from the subjects of such control both to employers with the aim of guaranteeing certain social standards, ensuring constitutional rights (preserving life, health, etc.), and to state control bodies with the aim of introducing such demands into the regulatory and legal field. That is, the tasks of public control are not only the detection of deviations from the observance of labor protection norms by controlled objects, it is much broader and reflects the influences and demands of civil society.
The article concludes that a civil society has been formed in Ukraine, whose institutions can take over certain functions of monitoring compliance with labor legislation, especially during martial law, when the risks of illegal actions on the part of employer’s increase.
Definition and Measurement of Corruption in the States of the European Union and the Use of Directions for Assessing Corruption Actions in Ukraine
Authors: Kotukov Oleksandr , Solovykh Vitalii
Published: December 2023

The article reveals issues related to corruption, which has a negative impact on social security, public spending, budget deficit, tax collection, vulnerable employment, gender equality and the use of EU funds, and approaches to its measurement. It is noted that corruption is associated with an increase in the level of organized crime, a weakening of the rule of law, a decrease in voter turnout in parliamentary elections and trust in state institutions. It is noted that the pandemic and subsequent socio-economic crises called into question the adequacy of the existing mechanisms for controlling the unprecedented volume of finances within the framework of the EU recovery plan. In this complex context, legal and policy frameworks as well as EU instruments that assess anti-corruption efforts are important at all times. But at the same time, all EU member states, solving this problem, have different approaches and methods of its grouping and measurement. According to the conducted studies, there are currently no corruption-free zones in the EU, as all member states have touched this problem, albeit to varying degrees. The concept of corruption is defined as a broader socio-economic problem that covers a number of issues, namely: conflict of interests; clientelism; various forms of favoritism; influence peddling and other similar forms of behavior. A study of modern statistics of corruption offenses as of the first half of 2023 was conducted, which shows positive developments in Ukraine in the fight against corruption, but at the same time, the rate of violations of financial control requirements remains extremely high. Given the difficulty of directly measuring corruption, various (indirect) indicators have been developed based on the perception or experience of this phenomenon and an attempt to quantify the cost of corruption in the EU. It is noted that the main international study is the Global Corruption Barometer (GCB), which collects data on the experience and perception of corruption around the world since 2003. In 2021, the Global Corruption Barometer (GCB) – EU focused on measurements in EU Member States, which confirmed the widespread perception of corruption in Europe and showed that EU citizens are concerned about the close ties between business and politics. Therefore, in the article, the author examines issues related to the measurement of corruption for the possibility of more accurately forecasting the development of this negative phenomenon in the future and taking appropriate preventive measures.
European Integration and Countering Hybrid Threats: Challenges and Prospects
Authors: Myrna Nadiya , Bilokon Mykhailo
Published: December 2023

The relevance of the article’s topic is determined by the non-standard nature of the challenges and threats of today. In the modern world, hybrid threats have become a major challenge for European countries, the European Union, and the world as a whole. Hybrid warfare encompasses various forms and types of aggression that are used to influence a country’s domestic politics, public opinion, and government activities.
Hybrid threats are complex and multifaceted phenomena that require a comprehensive and systemic approach to counter them. They can target different spheres of life, such as politics, economy, culture, the information space, and others. Since they have an unpredictable nature, countering them requires the development and implementation of modern strategies and effective tools at both the national and supranational levels.
The European Union must develop an effective strategy to counter hybrid threats that would allow it to protect its citizens and prevent the further expansion of these threats.
Therefore, the process of Eurointegration is an important element in countering hybrid threats for countries and the region as a whole. The European Union provides significant support in combating hybrid threats, including through cooperation and coordination with member countries. One important element of Eurointegration is the alignment of legislation and security standards among countries. This helps reduce risks and enhance protection against hybrid threats. Collaboration in the field of cybersecurity is also a crucial component of Eurointegration. The development and implementation of joint strategies and tools enhance the effectiveness of countering hybrid threats at the regional level. Furthermore, Eurointegration can assist countries in developing and implementing new strategies and tools to counter hybrid threats, including through financial and technical support. This will enable more effective combat against these phenomena and ensure the security of countries and the region as a whole.
The EU’s approach to defining and addressing hybrid threats is outlined in the «Joint Framework on Countering Hybrid Threats - European Union Response» (2016), «Increasing Resilience and Strengthening the Capacity to Address Hybrid Threats» (2018), and the EU Security Strategy (2020). The integrated system for countering hybrid threats encompasses a wide range of measures at both the member state and supranational EU levels, including early detection, analysis, raising awareness, building resilience, prevention, crisis response, and consequence management.
Labor Rights of Minors Under Martial Law in Ukraine
Authors: Dubovyk Kateryna
Published: December 2023

In this article, the main attention is paid to the protection of the labor rights of minors in the conditions of martial law and hostilities that are ongoing in Ukraine, during the hostilities, the Ukrainian labor market lost a quarter of the able-bodied population, who were evacuated abroad. In such a situation, employers are forced to place minors in private enterprises and institutions, compensating for the resources of employees and taking into account the fact that as a result of the de-occupation of the territories, services for children have ceased to function to protect the rights of minors. At the same time, it is necessary to understand all the risks of the post-war labor market and, at the legislative level, create conditions for its stabilization and retention of citizens in their workplaces with respect for guaranteed human rights. This especially applies to minors who already work at Ukrainian enterprises or plan to work for them. Accordingly, it is relevant to study the specifics of ensuring the labor rights of minors under martial law.
Modification of free fatty acid test for food products containing fat and organic
acid
Authors: Su'i M. , Sumaryati E. , Anggraeni F.D. , Suprihana S. , Mustika M. , Utomo Y.
Published: December 2023

The free fatty acid test in food products containing fat (insoluble water) and organic acid
(soluble water) usually uses the titration method with ethanol solvent. However, the free
fatty method with 1 step titration detected both free fatty acid and non-fatty acid.
Therefore, this study aimed to modify the free fatty acid test method in food products
containing fat and organic acid. This research used free fatty acid methods with two steps
of titration. Oil and acetic acid were used as a sample in the first step, while yogurt was
used in the second titration step. The results showed that the free fatty acid method in food
products containing fat and organic acids should be done with two-step titration using
ethanol and distilled water solvent in steps 1 and 2, respectively. The amount of free fatty
acids in the first and the second titration differed. The two-step titration method exhibited
a free fatty acid content of about 0.27%, which was higher than the one-step titration. The
different titration results between ethanol and distilled water were in NaOH volume used
by free fatty acids. Therefore, the analysis of free fatty acid in food containing fat/oil and
water-soluble organic acids were more precise using the two-step titration than one-step
titration.
Effect of papaya leaf (Carica papaya) boiled water and honey to reduce
menstrual pain in teenage girls in Indonesia
Authors: Handajani S.H. , Astuti E.W. , Dewi I.K.
Published: December 2023

Premenstrual or menstrual cramping can cause pain or discomfort in the lower abdomen.
Although it can range from minor to severe, menstrual discomfort can be disruptive to
daily life. Both pharmaceutical and non-pharmacological therapies can be used to alleviate
menstrual discomfort. Papaya leaves (Carica papaya) and honey are two natural
components that are thought to be used in one of the ancient remedies to lessen
menstruation pain. Vitamin E, which is found in papaya leaves, can lessen menstruation
pain. Because honey includes glucose and fructose, which regulate the smooth muscles of
the uterus, there is less pain associated with menstruation because the uterine muscles can
relax. This research aimed to determine the effect of boiled papaya leaf water and honey
on reducing menstrual pain in adolescent girls at Ngawen II Public Health Center
Gunungkidul. With a single group pretest-posttest design, this study employs a quasiexperimental methodology. A total of 184 teenage females with menstruation discomfort
at the Ngawen II Public Health Center in Gunungkidul participated in this study. The tpaired test was used to process the data. According to the findings, adolescent
menstruation pain levels decreased on average from -2.65 to 2.29. The results of statistical
testing revealed a p-value of 0.000, indicating that there is a difference between giving
teenagers functional drink items made from boiled papaya leaves, water, and honey in
reducing menstruation pain. Therefore, boiled papaya leaf water and honey can be an
alternative to lessen adolescent girls' menstrual pain.
Technological Transformation of Accounting – Need for Firms to add Technology Training Employee Skill Sets
Authors: Fetzer Thomas Hennefer , Gibson Yan Shi , Kuhn John Randel
Published: December 2023

Purpose: The objective of this study is to determine the impact of the ineffective use of technology by accounting firms on employee skill sets.
 
Theoretical framework: This study will focus on exploring the relationship between the use of technology in the accounting profession and employee  training for both accounting and technology skills.
 
Design/Methodology/Approach: A flexible research design with qualitative methods (specifically, a case study) was used in this study. Data collection methods for the study included interviews and surveys of accountants in the intermountain region of the United States at a regional accounting firm. Triangulation helped to create potency and legitimacy of the study by comparing the results from the multiple data sources of surveys, interviews, literature reviews, and quantitative summaries.
 
Findings: The findings from the study confirm the existence of problems identified in this study and provide information to the current body of knowledge concerning the ineffective use of technology at an accounting firm due to a difference between traditional accounting skills and technology skills. Six themes emerged: 1) technology is essential for accountants to effectively perform their jobs, 2) support from the leadership of an accounting firms is essential for successful technology use, 3) in-house and internal IT staff are critical for successful technology use, 4) different generations of accountants perceive and use technology differently, 5) clients are a major driver of an accounting firm’s technology, and 6) the audit profession has and is changing dramatically due to technology.
 
Research, Practical & Social implications: The study confirms the existence of problems identified in this study and provide information to the current body of knowledge concerning the ineffective use of technology at an accounting firm due to a difference between traditional accounting skills and technology skills. 
 
Originality/Value: The value of this study provides support on technology skill sets for accounting professionals that will help the accounting profession be better prepared to source and train staff accountants with the necessary skills to capitalize on the unfolding technology transformation.  This, may in turn, help accounting firms produce better services and products.
Valuation of Intellectual Capital: An Empirical Analysis of Human Capital in SMEs in Ecuador
Authors: Villa Luis Ernesto López , Zumba Ana del Rocío Cando , Orozco Fernanda Matilde Bastidas , Pazmiño María Fernanda Oñate
Published: December 2023

Purpose: The objective of this study was to determine the valuation between intellectual capital and human capital in  SMEs in Ecuador.

 

Theoretical framework: Recent literature has reported interesting results on the application of organizational theoretical models and the knowledge society. However, there is still much to investigate and learn about organizational models and cultures in  SMEs in Ecuador. (Saavedra & Saavedra, 2012)

 

Design/methodology/approach:  A cross-sectional design with a qualitative approach was implemented. An empirical study is carried out where the intellectual capital of the  SMEs is evaluated through human capital as a dependent variable, and three variables as independent: Values ​​and attitudes, skills and abilities, through the application of a structured questionnaire through an interview with 378 businessmen. of the manufacturing, commerce and services sector of Ambato and Riobamba in Ecuador. It began with the descriptive analysis of the composition of the sample and the statistical results are evidenced through an analysis of means.

 

Findings:  The results showed that according to the composition of the sample by company size, microenterprises have between 1 and 9 employees, small companies manage between 10 and 49 workers and medium-sized companies between 50 and 199 employees, being representative, such as drivers. of the economy in Ecuador. One problem is the relevant presence of microenterprises, which generally maintain low-quality jobs and minimum wages.

 

Research, Practical & Social implications:  We suggest valuing human capital in  SMEs . This research establishes a sense of belonging and commitment, which allows you to socialize with the client and develop your creativity. Likewise, the feeling of belonging establishes that the worker feels an integral part of the company, trusting the administrators, having freedom and autonomy to plan their work and avoiding high turnover, ensuring their permanence in the company. This value allows SMEs to develop and workers to increase their productivity by working in an appropriate environment.

 

Originality/value:  The results showed that the  SMEs businessman considers it relevant to hire an experienced worker who maintains personal development by involving his family, the company carries out social, cultural activities and specialized training that contributes to improving the development of the company, allowing the hiring of personnel with a graduate degree or specialization. technical, offering training with specific skills for the development of the company.
Huellas de la memoria y memorias de la huella
Authors: Crémaux-Bouche David
Published: December 2023

Resumen: Casi un siglo después de la Retirada (1939), los exiliados siguen empleando la expresión «campos de concentración» para remitir a los campos improvisados que se construyeron en Francia para «acogerlos». Esta terminología tiene connotaciones fuertes después de la Segunda Guerra Mundial de las cuales se adueñan los autores de cómics para contrarrestar la anomalía historiográfica que caracteriza a este exilio que solo se estudió hace unas décadas. Utilizan huellas del imaginario de la historia bien conocidas por parte del público para que emerja una nueva memoria a partir de estas huellas: la de la Retirada. En este artículo, se analiza la hermenéutica creadora de la huella, así como su reversibilidad creadora en torno a la Retirada mediante el estudio de recursos gráficos, narratológicos o simbólicos en cuatro novelas gráficas (Un largo silencio, El arte de volar, Los Surcos del azar, El ángel de la Retirada).

Abstract: Almost a century after the Retirada (1939), exiles continue to use the expression "concentration camps" to refer to the improvised camps that were built in France to "accommodate" them. This terminology has strong connotations after the Second World War, which the comic strip authors use to counteract the historiographical anomaly that characterises this exile, which was only studied a few decades ago. They use traces of the imaginary of history that are well known to the public so that a new memory emerges from these traces: that of the Retirada. In this article, we analyse the creative hermeneutics of the trace, as well as its creative reversibility around the Retirada through the study of graphic, narratological or symbolic resources in four graphic novels (Un largo silencio, El arte de volar, Los Surcos del azar, El ángel de la Retirada).
Long-term effects of nitrogen enrichment in pollen chemistry of a plant species from Brazilian savannas, Pavonia rosa campestris
Authors: Carvalheiro Luisa , Vanderplanck Maryse , M.C. Bustamante Mercedes
Published: December 2023

Human activities have substantially increased soil nutrient availability during the past decades, affecting plant community composition and plants' nutritional content. Several amino acids found in pollen, the main source of larval diet for bees, affect the development, health, and behaviour of this important group of pollinators. A better understanding of the consequences of global changes on pollen amino acid content can help explain and predict future impacts on bee populations and diversity. This is particularly relevant in regions that are highly exposed to fertilizers due to their importance for global food production, such as the Brazilian savannas (Cerrado), where soils are mostly dystrophic.
Here, we use a long-term controlled fertilization experiment conducted in Cerrado and demonstrate that even after 10 years since the last fertilization addition, effects were still detectable on leaf and pollen chemical content. More specifically, pollen amino acid content of Pavonia rosa-campestris (Malvaceae), a species known to be important for the diet of several native bee species, changed because of nitrogen (N) addition. Not only did the overall amino acid content increase with N addition, but its profile was also affected, with the proportion of some amino acids increasing (e.g. isoleucine, leucine, serine, threonine), while decreasing for others (e.g. cysteine).
These amino acids can have important effects on larval development and flower visitor behaviour. Further studies evaluating the effects on a diverse set of plant species and the consequent impacts on flower visitation and bee fitness are essential to better understand the full consequences of increased nitrogen availability in nutrient-limited ecosystems such as Cerrado.
Increasing the capacity of health cadres to prevent and self-management of Osteoarthritis
Authors: Triyanto Arifin , Pangastuti Heny Suseani , Nurlita Diana , Umami Anisah
Published: December 2023

Osteoarthritis (OA) is a clinical syndrome characterized by joint pain with varying degrees of functional limitations that impact quality of life. Data in Indonesia shows that the national prevalence of osteoarthritis is 7.3%. Several factors in the high prevalence of OA that can be modified require lifestyle modification to prevent OA. Self-management in OA can help maintain the individual's functional capacity, improve self-image, and improve the quality of life of the patients. This community service is health education for health cadres and the general public over the age of 35 years in one of the areas in Godean, Sleman, Yogyakarta. The team measured the level of participants' knowledge about osteoarthritis and self-screening for osteoarthritis in community service. Results obtained the majority of respondents were in the mild osteoarthritis category (36.5%). The results of the respondents' knowledge scores were the difference in average knowledge before and after providing education, there was an increase in knowledge scores of 17.87. Providing health education can increase public knowledge about osteoarthritis before and after health education about prevention and self-management of osteoarthritis.
Implementation of renewable energy using smart light solar cell system for mosque energy efficiency
Authors: Hariyanto Wahyu , Utama Shoffin Nahwa , Fatchurrohman Fatchurrohman
Published: December 2023

The outreach activity focuses on improving energy efficiency at Sirothol Mustaqim Mosque in Pasuruan Regency. The primary issue addressed is how to meet the lighting needs of the mosque while minimizing the use of PLN electricity and optimizing the use of lamps and electricity based on the number of congregants. The main objective is to implement renewable energy through solar panels to replace conventional electricity, analyze the efficiency of electricity usage based on lighting requirements, and enhance electricity efficiency based on time and lamp location. Expected outcomes include increased electricity usage efficiency, reduced operational costs for mosque management, and advanced scientific and technological knowledge in the general community. The participatory action research (PAR) method emphasizes active participation and collaboration between academics and the community. The project commences with a field survey to identify energy needs and the potential for solar energy sources on-site. Subsequently, project planning and design are carried out, followed by project implementation with training for mosque administrators. The results of the project's implementation include energy usage efficiency, the integration of renewable energy in a religious context, and contributions to understanding environmental responsibilities. The success of the implementation measure calculations for the usage time of 40-watt lamps using solar energy are provided, along with a comparison of PLN electricity costs and solar energy usage costs. The analyses demonstrate favorable energy efficiency using solar power.
Nutritional value and contamination testing assistance for the improvement of the processed food products quality
Authors: Hamdani Syarif , Firmansyah Adang , Faruqi Muhammad Ismail , Astriany Dewi , Gustini Sri , Winingsih Wiwin , Sundalian Melvia , Setiani Nur Asni , Afiyanti Putri
Published: December 2023

Micro, Small, and Medium Enterprises (MSMEs) are one of the business sectors driving the country's economy. MSMEs produce many quality products that can compete in the market, where one of the products that is marketed quite a lot is food products. Several MSMEs in the Purwakarta Regency area have not included information on nutritional value and contamination on labels or packaging so these products cannot be widely marketed or traded in official stores and can only be marketed in their production areas. The Community Service activities carried out aim to carry out nutritional value and contamination tests, followed by improving product quality through workshops and mentoring. The food products targeted are simping and instant turmeric drinks produced by MSMEs in Pondoksalam District, Purwakarta Regency. Laboratory test results show that instant turmeric does not meet several SNI standard parameters, so quality improvement is still needed to be able to adapt it to become a product that meets standards. The results of the questionnaire show that several MSME owners in the Purwakarta area have a poor understanding of food product quality standards and ways to improve them. The coaching program for community service activities shows an increase in knowledge and understanding so that food products from Purwakarta MSMEs are expected to meet product quality standards in the future.
Improving elderly life: Foot exercises for blood sugar control and enhanced quality of life
Authors: Kartini Yanis , Faizah Imamatul , Noventi Iis , Aisyah Aisyah , Fitriyah Elly
Published: December 2023

Elderly people are at risk of developing degenerative diseases, one of which is diabetes mellitus. Diabetes management includes education, diet management, physical activity, and pharmacotherapy. This community service aims to determine changes in blood sugar levels after doing leg exercises to improve the quality of life of the elderly. The service participants were 51 cadres and elderly people at the Cempaka Putih Kedung Anyar Elderly Integrated Healthcare Center, Sawahan District, Surabaya City. Community service activities include; checking blood sugar levels, counseling about diabetes mellitus and foot exercise training. The success of community service is assessed based on the activeness of the elderly in doing foot exercises and a comparison of the results of checking blood sugar levels before and after being given foot exercise exercises. Before being given the leg exercise, there were 21 people (41%) whose blood sugar levels were high, and after doing the leg exercise, there was a decrease to 10 people (19.6%) who had high blood sugar levels, and almost all respondents had 80% blood sugar levels. normal. Foot exercises can lower blood sugar levels in the elderly. Regular foot exercises can maintain blood sugar levels in normal conditions. People can apply foot exercises regularly so that blood sugar levels are normal and the quality of life improves.
Inquiry-based training of olericulture cultivation to improve students' industrial agriculture insight and entrepreneurship spirit
Authors: Nurroniah Zhahrotun , Sani Safina Aulia , Wulandari Rike Dwi , Anggraeni Nadiah Putri , Mashitoh Nidya Nur , Nuraini Lailatul
Published: December 2023

Penelitian ini bertujuan untuk meningkatkan pemahaman industri pertanian dan jiwa kewirausahaan siswa SD Jomerto 02 Patrang melalui budidaya bibit olerikultur berbasis inkuiri. Salah satu tanaman yang mudah ditanam dan mempunyai hasil panen yang mahal adalah tanaman olerikultur. Metode pelaksanaan layanan yang digunakan peneliti adalah pendekatan Service Learning (SL). Hasil penelitian ini menunjukkan hasil rekapitulasi guru sebesar 97,5% termasuk dalam kategori sangat baik, dan hasil rekapitulasi siswa pada ketiga indikator berada pada kategori sangat baik. Hal ini dibuktikan dengan data hasil persentase indikator efikasi diri sebesar 82,45%, data hasil persentase indikator kebutuhan prestasi sebesar 90,96% dan data persentase hasil indikator niat berwirausaha sebesar 92,34%. Dengan kata lain, upaya meningkatkan pemahaman industri pertanian dan jiwa kewirausahaan siswa SDN Jomerto 02 Patrang dapat dilanjutkan oleh pihak sekolah.
Fish pellet development utilizing BSF Maggot by-product organic fertilizer for economic growth
Authors: Rusdianto Andrew Setiawan , Aldini Achmad Shorfi , Wulandari Fitri , Fauziayah Dian Nur , Marella Larissa Nathania , Ratnawati Anika , Hayati Nur , Azis Ahmad Nurul , Febrian Zuhal , Simanjuntak Ferdinand , Zuhdi Ahmad Rafid
Published: December 2023

The village of Sukamakmur has the potential for freshwater fishery resources through catfish farming. Black Soldier Fly larvae (BSFl) cultivated by the Farmer Group Tirto Bakti II can solve farmers’ dependence on factory-made feeds, alongside the underutilization due to a lack of technological input in processing by-products. This service activity aims to develop the application of fish feed technology using BSFl to meet the nutritional needs of fish, increase the market value of fish pellet products, and establish partnerships with catfish farmers and community groups in the village. The development activities involve outreach efforts to explain the production process from the materials used to the manufacturing process. The product development results indicate that the material formulation used in making fish pellets consists of a successive mixture of BSFl: bran: fish meal: tapioca flour in a ratio of 4:2:1:1 with a floating capability of approximately 5-7 minutes. Based on the service activities that have been carried out, this service can encourage continued production in the Tirto Bakti II Farmer Group as a new initiative in managing BSFl, with the impact of improving the economy through new activities and marketing.
Recognizing former flood-tide deltas in the Holocene stratigraphic record from the Outer Banks, North Carolina, USA
Authors: Smith Christopher G. , Culver Stephen J. , Mallinson David J. , Riggs Stanley R. , Corbett D. Reide
Published: December 2023

Foraminiferal and sedimentologic data were collected by vibracoring a small, relict, short-lived, migrating inlet (New Inlet) and its flood-tide delta on the Outer Banks, North Carolina. These data, placed in the context of geospatial data derived from ground penetrating radar, were developed into a stratigraphic model for this sedimentary environment. The model was applied to vibracores collected from two additional barrier island segments within which historic inlets had not been recorded to investigate whether inlets had existed in these segments in the past. Five foraminiferal biofacies were recognized within the three barrier island segments. Biofacies 1 through 5 are all associated with interior and back-barrier depositional environments but Biofacies 4 and 5 contained foraminifera indicating a sediment source on the shoreface or shallow inner shelf. Biofacies 4 and 5 thus represent overwash or flood-tide delta depositional settings. Utilizing the model as an interpretive tool, we recognized a previously undocumented inlet and flood-tide delta that existed prior to 962-662 cal. yrs BP, a few kilometers north of Rodanthe, NC. However, at a barrier island segment between Avon and Buxton, NC, the lack of information on stratal geometry and foraminiferal assemblages meant that it could not be determined whether this sedimentary succession was influencedmore by overwash or inlet dynamics. Given the similarity of foraminiferal assemblages in overwash and flood-tide delta sediments, it is clear that additional lines of evidence (lithologic and geospatial) are required to recognize small-scale flood-tide delta deposits in the subsurface.