bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing Climate Forcing From the Sea Surface Temperature‐Surface Heat Flux Relation for SST‐Coupled Oscillatory Variability
Authors: Gu Peng , Liu Zhengyu
Published: June 2024

The interaction between sea surface temperatures (SST) and surface heat flux (SHF) is vital for atmospheric and oceanic variabilities. This study investigates SST‐SHF relationship in the framework of a coupled oscillatory model, extending beyond previous research that predominantly used AR‐1 type simple stochastic climate models. In contrast to the AR‐1 type model, we reveal distinct features of SST‐SHF relationships in the oscillatory model: sign reversals occur in the imaginary part of SST‐SHF coherence and the low‐pass SST tendency‐SHF correlation. However, these sign reversals are absent in the real part of SST‐SHF coherence and in the low‐pass SST‐SHF correlation. We find these features are robust across both the twentieth Century Reanalysis and GFDL SPEAR model for El Niño‐Southern Oscillation (ENSO) variability. Furthermore, we develop a new scheme to assess ENSO's climate forcing magnitude and natural frequency. Our findings thus provide novel insights into understanding ENSO dynamics from the perspective of heat flux.
Surfing Acceleration of Radiation Belt Relativistic Electrons Induced by the Propagation of Interplanetary Shock
Authors: Zhang Dianjun , Liu Wenlong , Li Xinlin , Sarris Theodore E. , Hao Yiwei , Zhang Zhao
Published: June 2024

Interplanetary shocks (IPS) can initiate prompt acceleration of relativistic electrons in the Earth's radiation belt, which is related to the generation and propagation of impulsive electric field (IEF). We investigate the effect of IEF on accelerating radiation belt electrons in the 6 September 2017 IPS event. A “surfing” effect of electrons with respect to the electric field, referring to electrons that drift together with the tailward‐propagating IEF in the duskside, is investigated in this study. Our results show that the maximum increase of electron differential flux is at 3.4 MeV by a factor of 2.2, corresponding to a drift velocity of 531 km/s, which is more consistent with the IPS propagating speed of 621 km/s rather than the fast‐mode speed of 1,074 km/s. We suggest that the effect of IPS propagation is important for radiation belt dynamics, and we highlight the potential importance of the parameter of IPS propagation speed.
Honeycomb‐Like Magnetosheath Structure Formed by Jets: Three‐Dimensional Global Hybrid Simulations
Authors: Ren Junyi , Guo Jin , Lu Quanming , Lu San , Gao Xinliang , Ma Jiuqi , Wang Rongsheng
Published: June 2024

Magnetosheath jets with enhanced dynamic pressure are common in the Earth's magnetosheath. They can impact the magnetopause, causing deformation of the magnetopause. Here we investigate the 3‐D structure of magnetosheath jets using a realistic‐scale, 3‐D global hybrid simulation. The magnetosheath has an overall honeycomb‐like 3‐D structure, where the magnetosheath jets with increased dynamic pressure surround the regions of decreased dynamic pressure resembling honeycomb cells. The magnetosheath jets downstream of the bow shock region with θBn ≲ 20° (where θBn is the angle between the upstream magnetic field and the shock normal) propagate approximately along the normal direction of the magnetopause, while those downstream of the bow shock region with θBn ≳ 20° propagate almost tangential to the magnetopause. Therefore, some magnetosheath jets formed at the quasi‐parallel shock region can propagate to the magnetosheath downstream of the quasi‐perpendicular shock region.
Rock Mineral Volume Inversion Using Statistical and Machine Learning Algorithms for Enhanced Geothermal Systems in Upper Rhine Graben, Eastern France
Authors: Joshua Pwavodi , Marquis Guy , Maurer Vincent , Glaas Carole , Montagud Anais , Formento Jean‐Luc , Genter Albert , Darnet Mathieu
Published: June 2024

Accurately determining the mineralogical composition of rocks is essential for precise assessments of key petrophysical properties like effective porosity, water saturation, clay volume, and permeability. Mineral volume inversion is particularly critical in geological contexts characterized by heterogeneity, such as in the Upper Rhine Graben (URG), where both carbonate and siliciclastic formations are prevalent. The estimation of mineral volumes poses challenges that involve both linear and nonlinear relationships associated with geophysical data. To address this complexity, our methodology strategically integrates the robust insights from standard statistical approaches with three machine learning (ML) algorithms: multi‐layer perceptron, random forest regression, and gradient boosting regression. Furthermore, we propose a new hybrid ensemble model that incorporates a weighted average of multiple ML approaches to predict mineral composition within the Muschelkalk and Buntsandstein formations of the URG. ML techniques for mineral composition prediction in these formations exhibit robust predictive performance. The predicted mineral volumes align closely with quantitative estimates derived from X‐ray diffraction analysis. Additionally, they are in good qualitative agreement with mineral descriptions obtained from cores and cuttings of the Muschelkalk and Buntsandstein formations.
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes
Authors: Sharma Abhibhav , Debik Julia , Naume Bjørn , Ohnstad Hege Oma ,   Oslo Breast Cancer Consortium (OSBREAC), Sahlber Kristine Kleivi , Borgen Elin , Børresen-Dale Anne-Lise , Engebråten Olav , Fritzman Britt , Garred Øystein , Geisler Jürgen , Geitvik Gry Aarum , Hofvind Solveig , Kristensen Vessela N , Kåresen Rolf , Langerød Anita , Lingjærde Ole Christian , Mælandsmo Gunhild Mari , Russnes Hege G , Sauer Torill , Skjerven Helle Kristine , Schlichting Ellen , Sørlie Therese , Bathen Tone F. , Giskeødegård Guro F.
Published: June 2024

Breast cancer (BC) is a leading cause of cancer-related death worldwide. The diverse nature and heterogeneous biology of BC pose challenges for survival prediction, as patients with similar diagnoses often respond differently to treatment. Clinically relevant BC intrinsic subtypes have been established through gene expression profiling and are implemented in the clinic. While these intrinsic subtypes show a significant association with clinical outcomes, their long-term survival prediction beyond 5 years often deviates from expected clinical outcomes. This study aimed to identify naturally occurring long-term prognostic subgroups of BC based on an integrated multi-omics analysis. This study incorporates a clinical cohort of 335 untreated BC patients from the Oslo2 study with long-term follow-up (>12 years). Multi-Omics Factor Analysis (MOFA+) was employed to integrate transcriptomic, proteomic, and metabolomic data obtained from the tumor tissues. Our analysis revealed three prominent multi-omics clusters of BC patients with significantly different long-term prognoses (p = 0.005). The multi-omics clusters were validated in two independent large cohorts, METABRIC and TCGA. Importantly, a lack of prognostic association to long-term follow-up above 12 years in the previously established intrinsic subtypes was shown for these cohorts. Through a systems-biology approach, we identified varying enrichment levels of cell-cycle and immune-related pathways among the prognostic clusters. Integrated multi-omics analysis of BC revealed three distinct clusters with unique clinical and biological characteristics. Notably, these multi-omics clusters displayed robust associations with long-term survival, outperforming the established intrinsic subtypes.
Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship
Authors: Kientega Tibila , Marcoux Sophie , Bourbonnais Jessica , Montpetit Jade , Caru Maxime , Cardin Guillaume B. , Arbour Nathalie , Marcil Valérie , Curnier Daniel , Laverdière Caroline , Sinnett Daniel , Rodier Francis
Published: June 2024

Childhood acute lymphoblastic leukemia (cALL) survivors suffer early-onset chronic diseases classically associated with aging. Normal aging is accompanied by organ dysfunctions, including immunological ones. We hypothesize that thymic immunosenescence occurs in cALL survivors and that its severity may correlate with early-onset chronic diseases. The PETALE study is a cALL survivor cohort with an extensive cardiovascular and metabolic evaluation. The thymic immunosenescence biomarker, signal joint T-cell receptor excision circles (TREC), was evaluated and was highly correlated with age in healthy participants (n = 281) and cALL survivors (n = 248). We observed a systematic thymic immunoage accentuation in each cALL survivor compared to controls ranging from 5.9 to 88.3 years. The immunoage gain was independent of age at diagnosis and treatment modalities and was more severe for females. Thymic aging was associated with several pathophysiological parameters, was greater in survivors suffering from metabolic syndrome, but there was no significant association with global physical condition. The decrease in TREC was independent from blood cell counts, which were normal, suggesting a segmental aging of the thymic compartment. Indeed, increased plasmatic T cell regulatory cytokines IL-6, IL-7 and GM-CSF accompanied high immunoage gain. Our data reveal that cALL or its treatment trigger a rapid immunoage gain followed by further gradual thymic immunosenescence, similar to normal aging. This leads to an enduring shift in accentuated immunoage compared to chronological age. Thus, accentuated thymic immunosenescence is a hallmark of cALL survivorship and TREC levels could be useful immunosenescence biomarkers to help monitoring the health of cancer survivors.
ZFHX3 acts as a tumor suppressor in prostate cancer by targeting FTO-mediated m6A demethylation
Authors: Hu Qingxia , Yin Junling , Zhao Sijie , Wang Yibo , Shi Ruxue , Yan Keqiang , Huang Shuhong
Published: June 2024

Zinc-finger homeobox 3 (ZFHX3, also known as ATBF1) suppresses prostatic tumorigenesis. ZFHX3 is frequently found to have numerous deletions in human prostate cancer (PCa). However, the underlying molecular function of ZFHX3 during prostatic tumorigenesis is not well understood. N6-methyladenosine (m6A) modification in RNA plays a critical role in the development of cancers; however, the relationship between ZFHX3 and m6A modification is largely unknown in PCa. In this study, we found that ZFHX3 knockdown decreased total m6A levels through enhancing the transcriptional activity of FTO in PCa cells. Importantly, FTO inhibition suppressed cell proliferation and rescued the promoting function of ZFHX3 knockdown on cell proliferation. In vivo, we verified that FTO was upregulated and ZFHX3 was decreased in PCa patients and that a high level of ZFHX3 is indispensable for low FTO expression and is correlated with better patient survival. Through transcriptome sequencing and MeRIP sequencing, we revealed that E2F2 and CDKN2C were the direct targets of FTO-mediated m6A modification and ZFXH3 was required for the regulation of FTO on E2F2 and CDKN2C expression. Unexpectedly, we uncovered that ZFHX3 expression was in return regulated by FTO in an m6A-dependent way. These findings establish a novel crosstalk mechanism between ZFHX3 and FTO in prostatic tumorigenesis.
A non-methanogenic archaeon within the order Methanocellales
Authors: Suzuki Shino , Ishii Shun’ichi , Chadwick Grayson L. , Tanaka Yugo , Kouzuma Atsushi , Watanabe Kazuya , Inagaki Fumio , Albertsen Mads , Nielsen Per H. , Nealson Kenneth H.
Published: June 2024

Serpentinization, a geochemical process found on modern and ancient Earth, provides an ultra-reducing environment that can support microbial methanogenesis and acetogenesis. Several groups of archaea, such as the order Methanocellales, are characterized by their ability to produce methane. Here, we generate metagenomic sequences from serpentinized springs in The Cedars, California, and construct a circularized metagenome-assembled genome of a Methanocellales archaeon, termed Met12, that lacks essential methanogenesis genes. The genome includes genes for an acetyl-CoA pathway, but lacks genes encoding methanogenesis enzymes such as methyl-coenzyme M reductase, heterodisulfide reductases and hydrogenases. In situ transcriptomic analyses reveal high expression of a multi-heme c-type cytochrome, and heterologous expression of this protein in a model bacterium demonstrates that it is capable of accepting electrons. Our results suggest that Met12, within the order Methanocellales, is not a methanogen but a CO2-reducing, electron-fueled acetogen without electron bifurcation.
Differences in regional brain structure in toddlers with autism are related to future language outcomes
Authors: Duan Kuaikuai , Eyler Lisa , Pierce Karen , Lombardo Michael V. , Datko Michael , Hagler Donald J. , Taluja Vani , Zahiri Javad , Campbell Kathleen , Barnes Cynthia Carter , Arias Steven , Nalabolu Srinivasa , Troxel Jaden , Ji Peng , Courchesne Eric
Published: June 2024

Language and social symptoms improve with age in some autistic toddlers, but not in others, and such outcome differences are not clearly predictable from clinical scores alone. Here we aim to identify early-age brain alterations in autism that are prognostic of future language ability. Leveraging 372 longitudinal structural MRI scans from 166 autistic toddlers and 109 typical toddlers and controlling for brain size, we find that, compared to typical toddlers, autistic toddlers show differentially larger or thicker temporal and fusiform regions; smaller or thinner inferior frontal lobe and midline structures; larger callosal subregion volume; and smaller cerebellum. Most differences are replicated in an independent cohort of 75 toddlers. These brain alterations improve accuracy for predicting language outcome at 6-month follow-up beyond intake clinical and demographic variables. Temporal, fusiform, and inferior frontal alterations are related to autism symptom severity and cognitive impairments at early intake ages. Among autistic toddlers, brain alterations in social, language and face processing areas enhance the prediction of the child’s future language ability.
Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial
Authors: McDermott Mary M. , Martens Christopher R. , Domanchuk Kathryn J. , Zhang Dongxue , Peek Clara B. , Criqui Michael H. , Ferrucci Luigi , Greenland Philip , Guralnik Jack M. , Ho Karen J. , Kibbe Melina R. , Kosmac Kate , Lloyd-Jones Donald , Peterson Charlotte A. , Sufit Robert , Tian Lu , Wohlgemuth Stephanie , Zhao Lihui , Zhu Pei , Leeuwenburgh Christiaan
Published: June 2024

People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respiration. Oral nicotinamide riboside (NR) increases bioavailability of NAD+ in humans. Among 90 people with PAD, this randomized double-blind clinical trial assessed whether 6-months of NR, with and without resveratrol, improves 6-min walk distance, compared to placebo, at 6-month follow-up. At 6-month follow-up, compared to placebo, NR significantly improved 6-min walk (+7.0 vs. −10.6 meters, between group difference: +17.6 (90% CI: + 1.8,+∞). Among participants who took at least 75% of study pills, compared to placebo, NR improved 6-min walk by 31.0 meters and NR + resveratrol improved 6-min walk by 26.9 meters. In this work, NR meaningfully improved 6-min walk, and resveratrol did not add benefit to NR alone in PAD. A larger clinical trial to confirm these findings is needed. Clinical Trials.gov registration: NCT03743636.
Bubbles enable volumetric negative compressibility in metastable elastocapillary systems
Authors: Caprini Davide , Battista Francesco , Zajdel Paweł , Di Muccio Giovanni , Guardiani Carlo , Trump Benjamin , Carter Marcus , Yakovenko Andrey A. , Amayuelas Eder , Bartolomé Luis , Meloni Simone , Grosu Yaroslav , Casciola Carlo Massimo , Giacomello Alberto
Published: June 2024

Although coveted in applications, few materials expand when subject to compression or contract under decompression, i.e., exhibit negative compressibility. A key step to achieve such counterintuitive behaviour is the destabilisations of (meta)stable equilibria of the constituents. Here, we propose a simple strategy to obtain negative compressibility exploiting capillary forces both to precompress the elastic material and to release such precompression by a threshold phenomenon – the reversible formation of a bubble in a hydrophobic flexible cavity. We demonstrate that the solid part of such metastable elastocapillary systems displays negative compressibility across different scales: hydrophobic microporous materials, proteins, and millimetre-sized laminae. This concept is applicable to fields such as porous materials, biomolecules, sensors and may be easily extended to create unexpected material susceptibilities.
Quantum control and Berry phase of electron spins in rotating levitated diamonds in high vacuum
Authors: Jin Yuanbin , Shen Kunhong , Ju Peng , Gao Xingyu , Zu Chong , Grine Alejandro J. , Li Tongcang
Published: June 2024

Levitated diamond particles in high vacuum with internal spin qubits have been proposed for exploring macroscopic quantum mechanics, quantum gravity, and precision measurements. The coupling between spins and particle rotation can be utilized to study quantum geometric phase, create gyroscopes and rotational matter-wave interferometers. However, previous efforts in levitated diamonds struggled with vacuum level or spin state readouts. To address these gaps, we fabricate an integrated surface ion trap with multiple stabilization electrodes. This facilitates on-chip levitation and, for the first time, optically detected magnetic resonance measurements of a nanodiamond levitated in high vacuum. The internal temperature of our levitated nanodiamond remains moderate at pressures below 10−5Torr. We have driven a nanodiamond to rotate up to 20 MHz (1.2 × 109rpm), surpassing typical nitrogen-vacancy (NV) center electron spin dephasing rates. Using these NV spins, we observe the effect of the Berry phase arising from particle rotation. In addition, we demonstrate quantum control of spins in a rotating nanodiamond. These results mark an important development in interfacing mechanical rotation with spin qubits, expanding our capacity to study quantum phenomena.
Genomic characterization of cervical lymph node metastases in papillary thyroid carcinoma following the Chornobyl accident
Authors: Morton Lindsay M. , Lee Olivia W. , Karyadi Danielle M. , Bogdanova Tetiana I. , Stewart Chip , Hartley Stephen W. , Breeze Charles E. , Schonfeld Sara J. , Cahoon Elizabeth K. , Drozdovitch Vladimir , Masiuk Sergii , Chepurny Mykola , Zurnadzhy Liudmyla Yu , Dai Jieqiong , Krznaric Marko , Yeager Meredith , Hutchinson Amy , Hicks Belynda D. , Dagnall Casey L. , Steinberg Mia K. , Jones Kristine , Jain Komal , Jordan Ben , Machiela Mitchell J. , Dawson Eric T. , Vij Vibha , Gastier-Foster Julie M. , Bowen Jay , Mabuchi Kiyohiko , Hatch Maureen , Berrington de Gonzalez Amy , Getz Gad , Tronko Mykola D. , Thomas Gerry A. , Chanock Stephen J.
Published: June 2024

Childhood radioactive iodine exposure from the Chornobyl accident increased papillary thyroid carcinoma (PTC) risk. While cervical lymph node metastases (cLNM) are well-recognized in pediatric PTC, the PTC metastatic process and potential radiation association are poorly understood. Here, we analyze cLNM occurrence among 428 PTC with genomic landscape analyses and known drivers (131I-exposed = 349, unexposed = 79; mean age = 27.9 years). We show that cLNM are more frequent in PTC with fusion (55%) versus mutation (30%) drivers, although the proportion varies by specific driver gene (RET-fusion = 71%, BRAF-mutation = 38%, RAS-mutation = 5%). cLNM frequency is not associated with other characteristics, including radiation dose. cLNM molecular profiling (N = 47) demonstrates 100% driver concordance with matched primary PTCs and highly concordant mutational spectra. Transcriptome analysis reveals 17 differentially expressed genes, particularly in the HOXC cluster and BRINP3; the strongest differentially expressed microRNA also is near HOXC10. Our findings underscore the critical role of driver alterations and provide promising candidates for elucidating the biological underpinnings of PTC cLNM.
Topological regression as an interpretable and efficient tool for quantitative structure-activity relationship modeling
Authors: Zhang Ruibo , Nolte Daniel , Sanchez-Villalobos Cesar , Ghosh Souparno , Pal Ranadip
Published: June 2024

Quantitative structure-activity relationship (QSAR) modeling is a powerful tool for drug discovery, yet the lack of interpretability of commonly used QSAR models hinders their application in molecular design. We propose a similarity-based regression framework, topological regression (TR), that offers a statistically grounded, computationally fast, and interpretable technique to predict drug responses. We compare the predictive performance of TR on 530 ChEMBL human target activity datasets against the predictive performance of deep-learning-based QSAR models. Our results suggest that our sparse TR model can achieve equal, if not better, performance than the deep learning-based QSAR models and provide better intuitive interpretation by extracting an approximate isometry between the chemical space of the drugs and their activity space.
Solution-state methyl NMR spectroscopy of large non-deuterated proteins enabled by deep neural networks
Authors: Karunanithy Gogulan , Shukla Vaibhav Kumar , Hansen D. Flemming
Published: June 2024

Methyl-TROSY nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for characterising large biomolecules in solution. However, preparing samples for these experiments is demanding and entails deuteration, limiting its use. Here we demonstrate that NMR spectra recorded on protonated, uniformly 13C labelled samples can be processed using deep neural networks to yield spectra that are of similar quality to typical deuterated methyl-TROSY spectra, potentially providing information for proteins that cannot be produced in bacterial systems. We validate the methodology experimentally on three proteins with molecular weights in the range 42–360 kDa. We further demonstrate the applicability of our methodology to 3D NOESY spectra of Escherichia coli Malate Synthase G (81 kDa), where observed NOE cross-peaks are in good agreement with the available structure. The method represents an advance in the field of using deep learning to analyse complex magnetic resonance data and could have an impact on the study of large biomolecules in years to come.
Hierarchical organic microspheres from diverse molecular building blocks
Authors: Li Yintao , Fan Longlong , Xu Xinyan , Sun Yang , Wang Wei , Li Bin , Veroneau Samuel S. , Ji Pengfei
Published: June 2024

Microspherical structures find broad application in chemistry and materials science, including in separations and purifications, energy storage and conversion, organic and biocatalysis, and as artificial and bioactive scaffolds. Despite this utility, the systematic diversification of their morphology and function remains hindered by the limited range of their molecular building blocks. Drawing upon the design principles of reticular synthesis, where diverse organic molecules generate varied porous frameworks, we show herein how analogous microspherical structures can be generated under mild conditions. The assembly of simple organic molecules into microspherical structures with advanced morphologies represents a grand challenge. Beginning with a partially condensed Schiff base which self-assembles into a hierarchical organic microsphere, we systematically synthesized sixteen microspheres from diverse molecular building blocks. We subsequently explicate the mechanism of hierarchical assembly through which these hierarchical organic microspheres are produced, isolating the initial monomer, intermediate substructures, and eventual microspheres. Furthermore, the open cavities present on the surfaces of these constructs provided distinctive adsorptive properties, which we harnessed for the immobilization of enzymes and bacteriophages. Holistically, these hierarchical organic microspheres provide an approach for designing multi-functional superstructures with advanced morphologies derived from simple organic molecules, revealing an extended length scale for reticular synthesis.
Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation
Authors: Schumacher Sina , Fernkorn Max , Marten Michelle , Chen Rui , Kim Yung Su , Bedzhov Ivan , Schröter Christian
Published: June 2024

The anterior-posterior axis of the mammalian embryo is laid down by the anterior visceral endoderm (AVE), an extraembryonic signaling center that is specified within the visceral endoderm. Current models posit that AVE differentiation is promoted globally by epiblast-derived Nodal signals, and spatially restricted by a BMP gradient established by the extraembryonic ectoderm. Here, we report spatially restricted AVE differentiation in bilayered embryo-like aggregates made from mouse embryonic stem cells that lack an extraembryonic ectoderm. Notably, clusters of AVE cells also form in pure visceral endoderm cultures upon activation of Nodal signaling, indicating that tissue-intrinsic factors can restrict AVE differentiation. We identify β-catenin activity as a tissue-intrinsic factor that antagonizes AVE-inducing Nodal signals. Together, our results show how an AVE-like population can arise through interactions between epiblast and visceral endoderm alone. This mechanism may be a flexible solution for axis patterning in a wide range of embryo geometries, and provide robustness to axis patterning when coupled with signal gradients.
Johnson-noise-limited cancellation-free microwave impedance microscopy with monolithic silicon cantilever probes
Authors: Shan Jun-Yi , Morrison Nathaniel , Chen Su-Di , Wang Feng , Ma Eric Y.
Published: June 2024

Microwave impedance microscopy (MIM) is an emerging scanning probe technique for nanoscale complex permittivity mapping and has made significant impacts in diverse fields. To date, the most significant hurdles that limit its widespread use are the requirements of specialized microwave probes and high-precision cancellation circuits. Here, we show that forgoing both elements not only is feasible but also enhances performance. Using monolithic silicon cantilever probes and a cancellation-free architecture, we demonstrate Johnson-noise-limited, drift-free MIM operation with 15 nm spatial resolution, minimal topography crosstalk, and an unprecedented sensitivity of 0.26 zF/√Hz. We accomplish this by taking advantage of the high mechanical resonant frequency and spatial resolution of silicon probes, the inherent common-mode phase noise rejection of self-referenced homodyne detection, and the exceptional stability of the streamlined architecture. Our approach makes MIM drastically more accessible and paves the way for advanced operation modes as well as integration with complementary techniques.
Strongly coupled magneto-exciton condensates in large-angle twisted double bilayer graphene
Authors: Li Qingxin , Chen Yiwei , Wei LingNan , Chen Hong , Huang Yan , Zhu Yujian , Zhu Wang , An Dongdong , Song Junwei , Gan Qikang , Zhang Qi , Watanabe Kenji , Taniguchi Takashi , Shi Xiaoyang , Novoselov Kostya S. , Wang Rui , Yu Geliang , Wang Lei
Published: June 2024

Excitons, pairs of electrons and holes, undergo a Bose-Einstein condensation at low temperatures. An important platform to study excitons is double-layer two-dimensional electron gases, with two parallel planes of electrons and holes separated by a thin insulating layer. Lowering this separation (d) strengthens the exciton binding energy, however, leads to the undesired interlayer tunneling, resulting in annihilation of excitons. Here, we report the observation of a sequences of robust exciton condensates (ECs) in double bilayer graphene twisted to ~ 10° with no insulating mid-layer. The large momentum mismatch between two graphene layers suppresses interlayer tunneling, reaching a d ~ 0.334 nm. Measuring the bulk and edge transport, we find incompressible states corresponding to ECs when both layers are in half-filled N = 0, 1 Landau levels (LLs). Theoretical calculations suggest that the low-energy charged excitation of ECs can be meron-antimeron or particle-hole pair, which relies on both LL index and carrier type. Our results establish a novel platform with extreme coupling strength for studying quantum bosonic phase.
Micro-optical elements from optical-quality ZIF-62 hybrid glasses by hot imprinting
Authors: Smirnova Oksana , Sajzew Roman , Finkelmeyer Sarah Jasmin , Asadov Teymur , Chattopadhyay Sayan , Wieduwilt Torsten , Reupert Aaron , Presselt Martin , Knebel Alexander , Wondraczek Lothar
Published: June 2024

Hybrid glasses derived from meltable metal-organic frameworks (MOFs) promise to combine the intriguing properties of MOFs with the universal processing ability of glasses. However, the shaping of hybrid glasses in their liquid state – in analogy to conventional glass processing – has been elusive thus far. Here, we present optical-quality glasses derived from the zeolitic imidazole framework ZIF-62 in the form of cm-scale objects. These allow for in-depth studies of optical transparency and refraction across the ultraviolet to near-infrared spectral range. Fundamental viscosity data are reported using a ball penetration technique, and subsequently employed to demonstrate the fabrication of micro-optical devices by thermal imprinting. Using 3D-printed fused silica templates, we show that concave as well as convex lens structures can be obtained at high precision by remelting the glass without trading-off on material quality. This enables multifunctional micro-optical devices combining the gas uptake and permeation ability of MOFs with the optical functionality of glass. As an example, we demonstrate the reversible change of optical refraction upon the incorporation of volatile guest molecules.
Extreme weather events do not increase political parties' environmental attention
Authors: Wappenhans Tim , Valentim António , Klüver Heike , Stoetzer Lukas F.
Published: June 2024

Exposure to extreme weather events can make people more aware of environmental changes; however, it remains unclear how such events influence politicians’ behaviour. Combining supervised learning algorithms on over 260,000 press releases by European parties with a difference-in-differences design, we find that apart from Green parties, extreme weather events do not increase attention towards environmental issues. This suggests the consequences of climate change might not directly increase political attention.
Resolving length-scale-dependent transient disorder through an ultrafast phase transition
Authors: Griffiths Jack , Suzana Ana F. , Wu Longlong , Marks Samuel D. , Esposito Vincent , Boutet Sébastien , Evans Paul G. , Mitchell J. F. , Dean Mark P. M. , Keen David A. , Robinson Ian , Billinge Simon J. L. , Bozin Emil S.
Published: June 2024

Material functionality can be strongly determined by structure extending only over nanoscale distances. The pair distribution function presents an opportunity for structural studies beyond idealized crystal models and to investigate structure over varying length scales. Applying this method with ultrafast time resolution has the potential to similarly disrupt the study of structural dynamics and phase transitions. Here we demonstrate such a measurement of CuIr2S4 optically pumped from its low-temperature Ir-dimerized phase. Dimers are optically suppressed without spatial correlation, generating a structure whose level of disorder strongly depends on the length scale. The redevelopment of structural ordering over tens of picoseconds is directly tracked over both space and time as a transient state is approached. This measurement demonstrates the crucial role of local structure and disorder in non-equilibrium processes as well as the feasibility of accessing this information with state-of-the-art XFEL facilities.
Phase angle and its determinants among adolescents: influence of body composition and physical fitness level
Authors: Ferreira Giovana O. C. , Ferrari Gerson , Langer Raquel D. , Cossio-Bolaños Marco , Gomez-Campos Rossana , Lázari Evandro , Moraes Anderson M.
Published: June 2024

To examine the association between levels of physical fitness, parameters of body composition and phase angle (PhA) amongst adolescents. A total of 152 adolescents (84 girls) aged 11–16 years were included in this study. Weight and height were measured and the body mass index (BMI) was calculated. Bioelectrical impedance analysis (BIA) provided resistance and reactance parameters to calculate fat-free mass (FFM), PhA and fat mass (%FM). The following physical fitness variables were analysed: flexibility, abdominal muscular endurance, upper and lower limb explosive strength, agility, speed and cardiorespiratory fitness. Generalized Linear Models were applied to verify differences across sexes. Stepwise linear regression was used to establish an association between the variables studied. The study established an association between PhA and weight, FFM, BMI, FM, %FM and medicine ball throw (MBT) for girls. As for the boys, an association was verified between PhA and weight, FFM, BMI, standing long jump (SLJ), MBT and the three allometric VO2peak variables analyzed. An association was found between PhA and the boys’ 4-m shuttle run test (4SRT) and 20-m sprint test (20SRT). Boys showed a greater phase angle than girls; In girls, BMI and %FM, were determinant of 32.4% (r = 0.57). PhA variability which is influenced by physical fitness, body composition and, therefore, the tissues electrical conductivity. Furthermore, boys’ height, FFM, upper limb strength, and agility account for 58.4% (r = 0.76) PhA variability. There was a positive correlation between the physical fitness tests and the PhA.
Being facially expressive is socially advantageous
Authors: Kavanagh Eithne , Whitehouse Jamie , Waller Bridget M.
Published: June 2024

Individuals vary in how they move their faces in everyday social interactions. In a first large-scale study, we measured variation in dynamic facial behaviour during social interaction and examined dyadic outcomes and impression formation. In Study 1, we recorded semi-structured video calls with 52 participants interacting with a confederate across various everyday contexts. Video clips were rated by 176 independent participants. In Study 2, we examined video calls of 1315 participants engaging in unstructured video-call interactions. Facial expressivity indices were extracted using automated Facial Action Coding Scheme analysis and measures of personality and partner impressions were obtained by self-report. Facial expressivity varied considerably across participants, but little across contexts, social partners or time. In Study 1, more facially expressive participants were more well-liked, agreeable, and successful at negotiating (if also more agreeable). Participants who were more facially competent, readable, and perceived as readable were also more well-liked. In Study 2, we replicated the findings that facial expressivity was associated with agreeableness and liking by their social partner, and additionally found it to be associated with extraversion and neuroticism. Findings suggest that facial behaviour is a stable individual difference that proffers social advantages, pointing towards an affiliative, adaptive function.
Estimation of minimum foot clearance using a single foot-mounted inertial sensor and personalized foot geometry scan
Authors: Fehr Katherine Heidi , Bartloff Jennifer Nicole , Wang Yisen , Hetzel Scott , Adamczyk Peter G.
Published: June 2024

The real-world measurement of minimum foot clearance (mFC) during the swing phase of gait is critical in efforts to understand and reduce the risk of trip-and-fall incidents in populations with gait impairments. Past research has focused on measuring clearance of a single point on a person’s foot, typically the toe—however, this may overestimate mFC and may even be the wrong region of the foot in cases of gait impairments or interventions. In this work, we present a novel method to reconstruct the swing-phase trajectory of an arbitrary number of points on a person’s shoe and estimate the instantaneous height and location of whole-foot mFC. This is achieved using a single foot-mounted inertial sensor and personalized shoe geometry scan, assuming a rigid-body IMU-shoe system. This combination allows collection and analysis using out-of-lab tests, potentially including clinical environments. Validation of single marker location using the proposed method vs. motion capture showed height errors with bias less than 0.05 mm, and 95% confidence interval of − 8.18 to + 8.09 mm. The method is demonstrated in an example data set comparing different interventions for foot drop, and it shows clear differences among no intervention, functional electrical stimulation, and ankle–foot orthosis conditions. This method offers researchers and clinicians a rich understanding of a person’s gait by providing objective 3D foot kinematics and allowing a unique opportunity to view the regions of the foot where minimum clearance occurs. This information can contribute to a more informed recommendation of specific interventions or assistive technology than is currently possible in standard clinical practice.
Newly developed CeO2 and Gd2O3-reinforced borosilicate glasses from municipal waste ash and their optical, structural, and gamma-ray shielding properties
Authors: Abou Hussein E. M. , Shaban S. E. , Rammah Y. S. , Misbah M. Hamed , Marzouk M. A.
Published: June 2024

From the useless municipal solid waste (MSW) ashes, CeO2, Gd2O3 and CeO2 + Gd2O3 doped borosilicate glasses were organized via melting-quenching procedure. Various optical, structural, physical and radiation shielding parameters were examined towards the influence of 100 kGy of γ-radiation. UV–visible NIR spectra revealed UV peaks at 351, 348 and 370 nm corresponding to the trivalent states of Ce3+ and Gd3+ ions, while, photoluminescence (PL) spectra displayed asymmetric broad excitations of Ce3+ and Gd3+ ions due to 4f → 5d transitions, and emission intense bands at 412, 434, and 417 nm. CIE chromaticity shows that Gd3+ ions increase the luminescence of Ce3+. FTIR absorption bands revealed an overlapping between tetrahedral groups of silicate (SiO4), with trigonal (BO3) and tetrahedral (BO4) units of borate. The influence of 100 kGy obtains quite reduction in UV–visible NIR and PL peaks, large stability in FTIR and ESR spectra, and stability of thermal expansion coefficient (CTE) as well. The whole data revealed optical, structural and physical stability of glasses after irradiation besides an enhancement in microhardness owing to more structural compactness and high bonding connectivity. Radiation shielding parameters from Phy-X/PSD program showed higher values of mass (MAC) and linear attenuation coefficients (LAC), and effective atomic number (Zeff) in the order of; glass Ce+Gd > glass Ce > glass Gd. Ce + Gd doped glass revealed also the lowest half value layer (HVL) comparing to other shielding commercial concretes. The study recommends the beneficial and economical use of the useless MSW ash to produce CeO2 and/or Gd2O3 borosilicate glasses with hopeful radiation shielding features.
Harnessing the potential of shared data in a secure, inclusive, and resilient manner via multi-key homomorphic encryption
Authors: Kang David Ha Eun , Kim Duhyeong , Song Yongsoo , Lee Dongwon , Kwak Hyesun , Anthony Brian W.
Published: June 2024

In this manuscript, we develop a multi-party framework tailored for multiple data contributors seeking machine learning insights from combined data sources. Grounded in statistical learning principles, we introduce the Multi-Key Homomorphic Encryption Logistic Regression (MK-HELR) algorithm, designed to execute logistic regression on encrypted multi-party data. Given that models built on aggregated datasets often demonstrate superior generalization capabilities, our approach offers data contributors the collective strength of shared data while ensuring their original data remains private due to encryption. Apart from facilitating logistic regression on combined encrypted data from diverse sources, this algorithm creates a collaborative learning environment with dynamic membership. Notably, it can seamlessly incorporate new participants during the learning process, addressing the key limitation of prior methods that demanded a predetermined number of contributors to be set before the learning process begins. This flexibility is crucial in real-world scenarios, accommodating varying data contribution timelines and unanticipated fluctuations in participant numbers, due to additions and departures. Using the AI4I public predictive maintenance dataset, we demonstrate the MK-HELR algorithm, setting the stage for further research in secure, dynamic, and collaborative multi-party learning scenarios.
Combating the causative agent of amoebic keratitis, Acanthamoeba castellanii, using Padina pavonica alcoholic extract: toxicokinetic and molecular docking approaches
Authors: Abdel-Hakeem Sara S. , Hassan Faten A. M. , Hifney Awatief F. , Salem Shimaa H.
Published: June 2024

Natural products play a significant role in providing the current demand as antiparasitic agents, which offer an attractive approach for the discovery of novel drugs. The present study aimed to evaluate in vitro the potential impact of seaweed Padina pavonica (P. pavonica) extract in combating Acanthamoeba castellanii (A. castellanii). The phytochemical constituents of the extract were characterized by Gas chromatography–mass spectrometry. Six concentrations of the algal extract were used to evaluate its antiprotozoal activity at various incubation periods. Our results showed that the extract has significant inhibition against trophozoites and cysts viability, with complete inhibition at the high concentrations. The IC50 of P. pavonica extract was 4.56 and 4.89 µg/mL for trophozoites and cysts, respectively, at 24 h. Morphological alterations of A. castellanii trophozoites/cysts treated with the extract were assessed using inverted and scanning electron microscopes and showed severe damage features upon treatment with the extract at different concentrations. Molecular Docking of extracted compounds against Acanthamoeba cytochrome P450 monooxygenase (AcCYP51) was performed using Autodock vina1.5.6. A pharmacokinetic study using SwissADME was also conducted to investigate the potentiality of the identified bioactive compounds from Padina extract to be orally active drug candidates. In conclusion, this study highlights the in vitro amoebicidal activity of P. pavonica extract against A. castellanii adults and cysts and suggests potential AcCYP51 inhibition.
Platelet-rich plasma attenuates the UPEC-induced cystitis via inhibiting MMP-2,9 activities and downregulation of NGF and VEGF in Canis Lupus Familiaris model
Authors: Abdelgalil Ahmed I. , Yassin Aya M. , Khattab Marwa S. , Abdelnaby Elshymaa A. , Marouf Sherif A. , Farghali Haithem A. , Emam Ibrahim A.
Published: June 2024

One of the most prevalent disorders of the urinary system is urinary tract infection, which is mostly brought on by uropathogenic Escherichia coli (UPEC). The objective of this study was to evaluate the regenerative therapeutic and antibacterial efficacy of PRP for induced bacterial cystitis in dogs in comparison to conventional antibiotics. 25 healthy male mongrel dogs were divided into 5 groups (n = 5). Control negative group that received neither induced infection nor treatments. 20 dogs were randomized into 4 groups after two weeks of induction of UPEC cystitis into; Group 1 (control positive; G1) received weekly intravesicular instillation of sodium chloride 0.9%. Group 2 (syst/PRP; G2), treated with both systemic intramuscular antibiotic and weekly intravesicular instillation of PRP; Group 3 (PRP; G3), treated with weekly intravesicular instillation of PRP, and Group 4 (syst; G4) treated with an intramuscular systemic antibiotic. Animals were subjected to weekly clinical, ultrasonographic evaluation, urinary microbiological analysis, and redox status biomarkers estimation. Urinary matrix metalloproteinases (MMP-2, MMP-9) and urinary gene expression for platelet-derived growth factor -B (PDGF-B), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) were measured. At the end of the study, dogs were euthanized, and the bladder tissues were examined macroscopically, histologically, and immunohistochemically for NF-κB P65 and Cox-2. The PRP-treated group showed significant improvement for all the clinical, Doppler parameters, and the urinary redox status (p < 0.05). The urinary MMPs activity was significantly decreased in the PRP-treated group and the expression level of urinary NGF and VEGF were downregulated while PDGFB was significantly upregulated (p < 0.05). Meanwhile, the urinary viable cell count was significantly reduced in all treatments (P < 0.05). Gross examination of bladder tissue showed marked improvement for the PRP-treated group, expressed in the histopathological findings. Immunohistochemical analysis revealed a marked increase in Cox-2 and NF-κB P65 in the PRP-treated group (P < 0.05). autologous CaCl2-activated PRP was able to overcome the bacterial infection, generating an inflammatory environment to overcome the old one and initiate tissue healing. Hence, PRP is a promising alternative therapeutic for UPEC cystitis instead of conventional antibiotics.
A process evaluation of a randomized-controlled trial of community gardening to improve health behaviors and reduce stress and anxiety
Authors: Coringrato Eva , Alaimo Katherine , Leiferman Jenn A. , Villalobos Angel , Buchenau Hannah , Decker Erin , Fahnestock Lara , Quist Pallas , Litt Jill S.
Published: June 2024

As part of the Community Activation for Prevention (CAPS) randomized controlled trial (RCT) of community gardening, we conducted a process evaluation to assess the implementation of a community gardening intervention over nine months, as measured by reach, fidelity (delivery, receipt, enactment), and acceptability. Evaluation instruments included repeated semi-structured interviews with study participants, direct observation of community garden sites, and an exit survey of participants. Primary outcomes were diet, physical activity, and anthropometry; secondary outcomes were stress and anxiety. The CAPS trial included 291 participants (19% non-white; 34% Hispanic/Latino; 35% without a college degree; 58% with income < $50,000 per year). Intervention delivery and receipt were high for environmental supports. Garden social events were offered by 73% of gardens, although only 48% of intervention participants reported attending these events. Of the 145 participants assigned to the gardening intervention, 97 (67%) reported gardening the entire season and reported visiting the community garden a median of 90 min per week (range: 0–840). Of the participants who completed the exit survey (48%), 89% were highly satisfied with the overall garden experience. The CAPS trial was favorably received and implemented with high fidelity, supporting the validity of the trial outcomes. These findings suggest that community gardens are a viable health promotion strategy that can be successfully implemented among new gardeners from diverse backgrounds. Strategies that engage new gardeners in the social aspects of the garden environment and connect gardeners with garden “mentors” or “buddies” to ensure new gardeners achieve success in their first years of gardening are recommended.

Trial registration: NCT03089177. Registered 24 March 2017, https://clinicaltrials.gov/study/NCT03089177.