bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling Holistic Healing: A comprehensive case study on the integrated management of Avaranjanya Pakshaghata
Authors: Vikhil Vijaykumar Darak  , Anupama Jitendra Shimpi
Published: June 2024

Pakshaghata is a condition where exacerbated Vata disrupts the vessels governing bodily functions, leading to constriction of sinews and affecting either the right or left side of the body. This results in symptoms such as loss of movement, pain, and speech impairment. Specific triggers can aggravate Vata, causing dryness in the Siras and Snayus, leading to hemiplegia or paralysis of one side of the body. Manifestations of Vata disorders can vary, including individual Vata aggravation, associated Vata aggravation, accumulation in bodily tissues or waste, and obstruction. Avarana, a complex concept in Ayurveda, plays a significant role in these conditions. In a case study discussed here, involving a 40-year-old male patient exhibiting loss of movement in the right upper and lower limbs and aphasia, the diagnosis was Kaphavrutta Udana Vyanjanita Pakkshaghata. Initially managed in an intensive care unit during the acute phase, the patient subsequently underwent Shamana treatment before undergoing Panchakarma and Vidhhakarma therapies.
The Origins of Armenian Lobbying in the United States: A Geopolitical Conceptualization of Restorative Justice
Authors: Payaslian Simon
Published: June 2024

This paper focuses on the origins of Armenian lobbying the U.S. government for favourable policies toward the Armenian cause in the homeland — that is, Ottoman Armenia and the Republic of Armenia (1918-1921). Vahan Cardashian, a New York lawyer, organized a lobbying campaign during and after the Young Turk genocide against the Armenian people in the Ottoman Empire (1915–1923). He and his associates formulated a geopolitical conceptualization of restorative justice. While Cardashian’s lobbying campaign eventually failed to exert the desired influence on U.S. policy during the Wilson administration, his strategy nevertheless established the foundations for Armenian lobbying in the United States for successive generations. This article seeks to contribute to the literature on ethnicity and ethnic lobbying a host state — in this case the United States — diasporan community and politics, and restorative justice.
‘Flanders Conquered the World’s Fair!’ Flemish newspaper discourses and nation-building during the 1958 Brussels World Exhibition
Authors: Degruyter Elias
Published: June 2024

This article examines the meaning of the ‘Flemish Day’ at the Brussels World Exhibition of 1958 for the formation of the Flemish nation. With this one-day festival pro-Flemish organisations contested the francophone character of the Expo, and francophone dominance in Belgian society. Its success announced the steep advance of the Flemish movement in the second half of the twentieth century. But how can we best interpret its impact on Flemish nation-building? The article analyses reactions on the Flemish Day in the Flemish press. Using six newspapers of diverse ideological strands it assesses support for Flemish emancipation. It thereby reveals a broad acceptance of the legitimacy of the Flemish Day, despite remarkable ideological differences. The discourse analysis supports the hypothesis that broadly shared interpretations of, and an almost unanimous identification with Flanders, provided the foundation for the mass spreading of Flemish consciousness in the 1960s and 1970s. Contributing empirical evidence to the study of nation-building in post-war Flanders, this article demonstrates the importance of media as mirrors and sources of national discourses.
Assessing the Relationship Between Vitiligo and Major Depressive Disorder Severity: Cross-Sectional Study (Preprint)
Authors: Molla Amr , Jannadi Raed , Alayoubi Hamza , Altouri Haya , Balkhair Maryam , Hafez Dareen
Published: June 2024

BACKGROUND

Vitiligo, a common dermatological disorder in Saudi Arabia, is associated with significant psychological impacts. This study explores the relationship between vitiligo and the severity of major depressive disorder (MDD), highlighting the broader implications on mental health among affected individuals.

OBJECTIVE

We aim to assess the prevalence and predictors of depression among adult patients with vitiligo, and to examine the relationship between MDD severity and vitiligo.

METHODS

Using a cross-sectional design, the research used the vitiligo area severity index and the Patient Health Questionnaire-9 to measure the extent of vitiligo and depression severity, respectively. This study involved 340 diagnosed patients with vitiligo from various health care settings. Logistic and ordinal regression analysis were applied to evaluate the impact of sociodemographic variables and vitiligo types on MDD severity.

RESULTS

The prevalence of MDD was 58.8% (200/340) of participants. Depression severity varied notably: 18.2% (62/340) of patients experienced mild depression, 17.9% (61/340) moderate, 11.8% (40/340) moderately severe, and 10.9% (37/340) severe depression. Female patients had higher odds of severe depression than male patients (adjusted odds ratio [aOR] 3.14, 95% CI 1.93-5.1; P<.001). Age was inversely related to depression severity, with patients aged older than 60 years showing significantly lower odds (aOR 0.1, 95% CI 0.03-0.39; P<.001). Lower income was associated with higher depression severity (aOR 10.2, 95% CI 3.25-31.8; P<.001). Vitiligo types also influenced depression severity; vulgaris (aOR 5.3, 95% CI 2.6-10.9; P<.001) and acrofacial vitiligo (aOR 2.8, 95% CI 1.5-5.1; P<.001) were significantly associated with higher depression levels compared to focal vitiligo.

CONCLUSIONS

The findings suggest that vitiligo contributes to an increased risk of severe depression, highlighting the need for integrated dermatological and psychological treatment approaches to address both the physical and mental health aspects of the disease.
Google Search Trends About Systemic Psoriasis Treatment: What Do People Want to Know About Biologics and Janus Kinase Inhibitors? (Preprint)
Authors: Lim Subin , Kooper-Johnson Sarah , Chau Courtney A , Chen Claire , Yang Fei-Shiuann Clarissa , Cobos Gabriela
Published: June 2024

UNSTRUCTURED
Movilidades y covid-19 en América Latina: inclusiones y exclusiones en tiempos de “crisis”
Authors: Vera Espinoza Marcia , López Villamil Stephanie , Gandini Luciana , Palla Irene , Vera Espinoza Marcia , Moulin Carlina , Fernández  de la Reguera Alethia , Zamora Gómez Cristina , Blouin Cécile
Published: June 2024

Este libro colectivo reúne un trabajo de investigación sistemático que el grupo CAMINAR (Comparative Analysis on International Migration and Displacement in the Americas) emprendió desde el inicio de la pandemia de la COVID-19, con el objetivo de analizar el impacto de la crisis sanitaria y económica en los procesos de inclusión de las personas migrantes, desplazadas y refugiadas en América Latina. Es resultado del proyecto de investigación ‘The crisis of forced displacement and responses to COVID-19 in Latin America’, que fue galardonado con una beca del decimoquinto ciclo de LASA-FORD Special Projects de la Latin American Studies Association (LASA). El conjunto de capítulos hilvanados por un propósito común y con una lente temporal específica, proporciona nuevos conocimientos sobre las políticas y prácticas de inclusión/exclusión de personas en movilidad en el contexto de las diversas crisis económicas y sociopolíticas por las que atraviesan los países de la región. Esta investigación se basa en un análisis comparativo de seis estudios de caso: Brasil, Chile, Colombia, México, Perú y Uruguay, sustentados en una metodología cualitativa que combina el análisis de marcos normativos y entrevistas semi-estructuradas con actores clave en cada país. El análisis revela una serie de ambigüedades, contradicciones y ausencias con relación a las políticas y prácticas que regulan la entrada, permanencia y acceso a derechos de las personas migrantes, que resultan en un espectro de inclusión/exclusión efectiva de las personas migrantes a derechos sociales y económicos, al tiempo que (re)configuran los procesos de gobernanza migratoria en la región. Finalmente, esta obra única contribuye a la construcción de una agenda emergente sobre los procesos de inclusión de personas migrantes en el Sur Global durante y más allá de la pandemia.
Uso de mamíferos silvestres terrestres y factores socioeconómicos que lo motivan en la Sierra Norte de Puebla, México.
Authors: Morales Jiménez Juan , Álvarez Gaxiola Jesús Felipe , Rosas Rosas Cesar Octavio , Olvera Hernández José Isabel , Tarando Arámbula Luís Antonio , Choy Flores Esther Octavi
Published: June 2024

La Sierra Norte de Puebla, es una región diversa en flora y fauna; sin embargo, sus comunidades rurales, tie­nen un grado de marginación alto, situación que provoca que los recursos naturales sean susceptibles de ser sobre utilizados. El objetivo, fue analizar la relación entre el uso de mamíferos silvestres terrestres medianos y grandes, con el nivel socioeconómico de la población, en dos municipios de la Sierra Norte de Puebla. Se aplicaron 158 entrevistas a jefes de familias; su nivel socioeconómico (NSE) fue calculado y su uso por ma­míferos silvestres medianos y grandes identificado. Para identificar la relación entre el nivel socioeconómico y el uso de mamíferos, se realizó un análisis de regresión logística. Las familias entrevistadas, tienen un nivel socioeconómico bajo y 48.7% de ellas, hace uso de mamíferos silvestres medianos o grandes. Aunque el NSE no influyó significativamente en el uso de mamíferos silvestres, la ocupación laboral, sí se asoció de manera significativa al aprovechamiento de dichos mamíferos.
VIVENCIAR O ENVELHECIMENTO EM CUIDADOS PALIATIVO: Uma revisão sistemática de literatura sobre a experiência do paciente idoso
Authors: Albuquerque Victória Machado de , Moreira Mariana Calesso
Published: June 2024

The increase in life expectancy drives the demand for extended care, triggering the phenomenon of aging amid care. Recognizing the relevance of palliative care as an approach that seeks comprehensive provision to foster quality of life in the face of chronic, incurable illnesses, this research aims to investigate the experience of aging in palliative care from the patient's perspective. It is a systematic review encompassing studies targeting elderly individuals in palliative care. The databases used included PubMed, SciELO, Lilacs, and Medline, with descriptors specified by Desh related to aging and palliative care. The final sample consisted of nine articles. The results converged around three recurring themes: the challenges faced by the elderly concerning chronic health demands, the coping strategies they adopt, and their involvement in the palliative care process and decisions related to their health condition. Although providing valuable insights into the experience of aging in palliative care, this study is limited by the scarcity of available research exploring the phenomenon from the patients' perspective. It is crucial to drive more investigations in this field, providing opportunities for patients to express their needs and experiences, aiming to enhance the quality of services and contributing to an ongoing improvement in quality of life and satisfaction with received care.
EDUCACIÓN ARTÍSTICA PARA LA REGIÓN DE ÑUBLE: PROPUESTA EDUCATIVA DESDE UNA UNIVERSIDAD ESTATAL
Authors: Faúndez Carreño Rodrigo , Faúndez Carreño Tania , Castro Rubilar Fancy , Castañeda Díaz María Teresa , Bivort Salinas Pablo
Published: June 2024

El presente artículo busca describir de los antecedentes académicos y de política pública que amparan la propuesta de creación de una nueva carrera de Pedagogía en Artes Integradas, inédita en Chile, elaborada por la Facultad de Educación y Humanidades de la Universidad del Bío-Bío en Chillán, a partir de un estudio comparativo de las ofertas de pregrado en el área. En su segunda parte, se analiza su malla curricular y perfil de egreso que apuntan a una mirada integral de la enseñanza de las artes, consensuada tras una encuesta – diagnóstico-, en el que participó el medio escolar, estudiantes, empleadores/as y profesores/as. Los resultados de la encuesta apuntan revelan el interés que suscita entre el público secundario la propuesta de una pedagogía en Artes Integradas, hecho que evidencia la necesidad de profesionales especialistas en esta área del conocimiento, avalando la pertinencia y contribución que la creación de la carrera tiene para la región y la contribución a las metas de la educación artística a nivel de pregrado en la Región de Ñuble.
COLABORACIONES PARA EL APRENDIZAJE EN EL AULA A INICIOS DEL COVID-19
Authors: Jiménez-Cruces Luis Alan
Published: June 2024

Esta experiencia de aprendizaje colaborativo se suscitó a inicios de la pandemia por Covid-19, específicamente durante el primer semestre académico del año 2020. La acción tuvo lugar en un colegio particular subvencionado de la ciudad de Valdivia en la región de Los Ríos y se enmarcó en la asignatura de Lenguaje y Comunicación para el segundo nivel de educación general básica (NB2). Estudiantes de 3er año básico complementaron sus habilidades de lectura y comprensión, abordando diversos textos instructivos con el fin de elaborar pan amasado. Se accionó de manera colaborativa con las familias para que apoyasen el proceso de enseñanza aprendizaje de los y las estudiantes en sus hogares. Los adultos fueron guías y mediadores en la concreción de dicha tarea. Los diversos actores involucrados en la experiencia pedagógica evaluaron y retroalimentaron lo vivido. Como consecuencia de lo anterior, la extrapolación del aula tradicional al hogar, la genuinidad de lo cotidiano, el bienestar psicoemocional y la contribución de apoderados/as para con los mecanismos evaluativos, se conciben como una de las grandes oportunidades para la educación y formación del estudiantado en contextos de emergencia.
Ārvalstu spriedumu atzīšana un izpilde Latvijas nacionālajās tiesībās: Atsevišķi problēmjautājumi
Authors:   Latvijas Universitāte, Kačevska Inga , Fillers Aleksandrs
Published: June 2024

European Union (EU) law plays a crucial role in the private international law of European states. Notably, the discussion about the recognition and enforcement of foreign judgments is often reduced to the analysis of the EU legal sources. However, recognition and enforcement of the judgment from third states still take place on the basis of domestic law (at least in the absence of international treaties). In this article, the authors focus on the critical analysis of the recognition and enforcement of third-state judgments in Latvian law. Initially, the authors discuss whether jurisdictional control is effective during the recognition stage. Further, the authors analyse the rule in the Latvian law that subjects foreign judgments to the applicable law test, i.e., whether a foreign court applied the same substantive law that would have been applied by a Latvian court. The authors conclude that not only this test lacks a legitimate objective, but its use in practice is complex and time-consuming. Hence, the authors suggest that the applicable law tests must be repealed.
Bērnu tiesību aizsardzība Krimināllikuma XVI nodaļas tvērumā. Izaicinājumi un perspektīvas
Authors:   Latvijas Universitāte, Kulmanis Oskars
Published: June 2024

This article is dedicated to assessment of the protection of the rights of children regarding sexual abuse cases, and the crucial importance of evaluating the vulnerable situation of the child. The article includes examination of practical elements determined by Paragraph 1 (iii) of Article 18 of Council of Europe Convention on the Protection of Children against Sexual Exploitation and Sexual Abuse, and Article 3 of the European Convention of Human Rights from the perspective of effective investigation of sexual abuse case. Recent challenges in court practice and discussions in legislative process emphasize the risks presented by leaving certain types of sexual abuse unpunished, and thus jeopardising the effective protection of the individual’s sexual autonomy. Therefore, the article will address the importance of assessing the particularly vulnerable situation of the child in sexual abuse cases to precisely characterize the criminal act.
Aizstāvības modeļu institucionālās un funkcionālās izpratnes evolūcija Latvijas kriminālprocesā
Authors:   Latvijas Universitāte, Lielbriede Linda
Published: June 2024

Criminal procedure has been subject to processes of historical evolution, constantly improving both the set of legal provisions for the detection and investigation of criminal offences, and clarifying the scope of activities, as well as the rights and obligations of the persons involved in criminal proceedings. Thus, the processes and results of the development of criminal procedure can also be viewed from the perspective of the effects incurred by these changes on the exercise of the powers conferred upon those exercising procedural functions. The author assesses the evolution of the institutionally established model of the right to defence in Latvian criminal proceedings, and the changes in the scope of the rights of the subjects vested with the respective function.
Starptautiska tribunāla izveides aspekti Krievijas–Ukrainas kara kontekstā
Authors:   Latvijas Universitāte, Gūtmane Alma Vilma
Published: June 2024

In response to Russia’s invasion of Ukraine, global focus shifts to holding Russian officials accountable for their crimes. With no current means to enforce accountability for the crime of aggression, the creation of a special international tribunal is a potential option. In the context of the Russia-Ukraine war, the author concludes that two options emerge, namely, a regional solution: a leading role of the Council of Europe in the establishment of an ad hoc international tribunal based on a multilateral treaty; or a tribunal established with a treaty between the UN and Ukraine, initiated by the UN General Assembly. The hybrid tribunal format is discouraged due to potential constitutional problems.
Extracto etéreo en semillas de zapallo (Cucurbita moschata Duchesne) en tres generaciones de endocría
Authors: Valdes Restrepo Magda Piedad , Ordoñez Narváez Ginna Alejandra , Ortiz Grisales Sanín
Published: June 2024

Context: Butternut squash seed is rich in ethereal extract with high quality long chain polyunsaturated fatty acids.
Knowledge gap: It is unknown how inbreeding influences the ethereal extract character in butternut squash seeds.
Purpose: The objective was to evaluate the performance of ethereal extract content and its associated seed characters of butternut squash C. moschata genotypes in three generations of inbreeding S0, S1 and S2 and to identify the predominant fatty acids.Methodology: A randomized complete block design was employed in six (6) genotypes, four (4) treatments and five (5) plants per experimental unit, inbreeding depression (ID) was assessed between generations for the variables ethereal extract (EE), seed weight per fruit (SWF), seed unit weight (SUW) and number of seeds per fruit (NSPF); for the identification of the fatty acids present in the EE, the technique of gas chromatography coupled to mass spectrometry (GC/MC) was used.
Results and conclusions: In genotypes 129 and 160 when passing from generation S0 to S1, they did not present DE in the EE character and when passing from generation S1 to generation S2, only genotype 129 presented -DE, the other genotypes increased the EE content. Fluctuations between genotypes were presented for the variables SWF, SUW and NSPF in which a differentiating factor between generations was not identified. When analyzing the EE, it was identified that 66.98% belong to monounsaturated and polyunsaturated fatty acids, where 60.15% belong to oleic acid, and the compound squalene, which is scarcely present in oilseeds, was found among the components.
Estimación de analitos del suelo en la altillanura, con teledetección sentinel-2 y modelos de regresión
Authors: Gómez Chávez Andrés Felipe , Feo Mahecha Jeimy Katherin , Parra Gonzalez Sergio David
Published: June 2024

Contextualization: Incorporation of new techniques and technologies to know the characteristics and composition of soils used in agricultural production is booming. The free license products such as Sentinel-2 satellite images, allow correlating the edaphic properties with spectral indices.
Knowledge gap: In the agricultural sector, the indices calculated from satellite images have been centered on characterization of vegetation. To a lesser proportion, studies have been carried out with indexes used in mineral prospecting to correlate with the chemical characteristics of the soil.
Purpose: This study was developed to evaluate the correlation of ferric oxide, ferrous silicate, ferrous iron, and alteration indices with the content of chemical elements of importance in crop production.
Methodology: A crop field of 282 hectares in the municipality of Puerto López in the department of Meta was selected. The evaluated indices from a set of Sentinel-2 imagery were calculated. After indices obtention, 40 sites were selected to do a soil composite sampling and determine the following characteristics: pH in water (1:1 potentiometric), Organic Matter (Walkey and Black), P (Bray II), Al (KCl 1N), Ca, Mg, K y Na (Ammonium acetate), Fe (DTPA). With the obtained information, a multiple regression analysis using the stepwise method was performed; as independent variables, the raster layers of the indexes calculated were used, and the variable to predict were the properties determined in the laboratory.
Results and conclusions: The evaluated indices showed a higher correlation to 0.60 with Ca and Mg content. A correlation between 0.40 and 0.60 was found between the indices and organic carbon y Fe. The regression models calculated give adjustments of 0.54, 0.47, and 0.33 for Mg, Ca, and Fe, respectively. The findings of this research allow us to understand from Sentinel-2 images that it is possible to obtain relevant indexes for agricultural production in conditions of the Colombian Plateau.
Unemployment in the Balkan countries and policies for its reduction
Authors: Osmani Nuhi , Nimani Petrit , Aqifi Berat , Maloku Artan
Published: June 2024

This paper examines the problem of unemployment in the Balkan countries, its causes, consequences, and policies. The paper analyzes the comparative aspects of unemployment in the region, highlighting the differences among the countries regarding economic development, labor market institutions, and structural reforms. The study argues that unemployment in the Balkan countries is a legacy of the transition from socialism to the market economy, which resulted in massive job losses, low productivity, skill mismatches, and informality (Cipan, 2019). Also, reviews the active and passive labor market policies implemented in the Balkan countries to address unemployment and evaluates their effectiveness and impact. The paper shows that the policies have been largely insufficient, fragmented, and poorly targeted, failing to address the structural and institutional barriers that hinder job creation and employment. The study concludes that unemployment in the Balkan countries is a complex and persistent challenge that requires a comprehensive and coordinated approach, involving both national and regional actors, as well as the support of the international community. The paper contributes to the literature on unemployment in the Balkan countries by providing a comprehensive and updated overview of the issue, and by suggesting some policy recommendations for its reduction.
Machine learning classification strategy to improve streamflow estimates in diverse river basins in the Colorado River Basin
Authors: Maebius Sarah , Schwenk Jon , Bennett Katrina E.
Published: June 2024

Streamflow in the Colorado River Basin is significantly altered by human
activities including land use/cover alterations, reservoir operation,
irrigation, and water exports. Climate is also highly varied across the
CRB which contains snowpack-dominated watersheds and arid,
precipitation-dominated basins. Recently, machine learning methods have
improved the generalizability and accuracy of streamflow models.
Previous successes with LSTM modeling have primarily focused on
unimpacted basins, and few studies have included human impacted systems
in either regional or single-basin modeling. We demonstrate that
modeling a group of river basins with diverse hydrological behavior
requires separate regional LSTM models. We propose a method to delineate
catchments into categories based on the level of predictability,
hydrological characteristics, and the level of human influence. Lastly,
we model streamflow in each category with climate and anthropogenic
proxy datasets and use feature importance methods to assess whether
model performance improves with additional relevant data. Overall, land
use cover data at a low temporal resolution was not sufficient to
capture the irregular patterns of reservoir releases, demonstrating the
importance of having high-resolution reservoir release datasets at a
global scale. On the other hand, the classification approach reduced the
complexity of the data and has the potential to improve streamflow
forecasts in human-altered regions.
Chemical process effects on sloped surface with changing mass and consistent temperature
Authors: Gnanavel Nagarajan , Mariadoss Sundarraj , Jayavelu Venkatesan , Polaka Venkata , Rajamanickam Muthucumaraswamy
Published: June 2024

The research extensively investigated the turbulent flow patterns surrounding
an unbounded inclined plate under the conditions of uniform temperature and
variable mass dispersion. Throughout this analysis, the study thoroughly
considered the impact of chemical reactions within the system. Focusing on
the harmonic inclination of the plate within its plane, the study employed
the LT approach to accurately solve the non-dimensional governing equations.
In scrutinizing various profiles, the investigation examined the impact of
several crucial physical factors: chemical response variable, Schmidt
number, thermal Grashof number, mass Grashof number, and duration. This
study delves into the intricate influence of various factors on the complex
flow dynamics surrounding inclined plates, specifically focusing on heat and
mass transfer phenomena. By examining these relationships, the research
provides crucial insights into improving the efficiency of thermal and mass
transmission processes within systems that incorporate tilted surfaces.
Moreover, this knowledge can potentially contribute to advancements in
various fields, from renewable energy systems to manufacturing processes,
where heat and mass transfer play pivotal roles.
Caracterización térmica de ríos de montaña regulados por aprovechamientos hidroeléctricos. Ejemplos del Pirineo Central
Authors: Carrero-Carralero Estrella , Vericat Damián , Batalla Ramon J. , Palau-Ibars Antoni
Published: June 2024

Los aprovechamientos hidroeléctricos alteran el régimen térmico del agua de los cursos fluviales en cuencas de montaña. Estos cambios de temperatura repercuten en numerosas variables fisicoquímicas, las cuales, a su vez, influyen en el hábitat físico de los sistemas fluviales. Dado que el régimen térmico en ríos perennes es ecológicamente significativo, se requiere un mayor conocimiento en diversas escalas temporales y espaciales. En este trabajo, se analizan los cambios observados a varias escalas temporales en el régimen térmico de dos tramos de ríos pirenaicos regulados por diferentes esquemas de aprovechamiento hidroeléctrico i.e. una central hidroeléctrica a pie de presa y una central con canal de derivación. Los resultados indican que las anomalías térmicas están relacionadas con el tipo de esquema de aprovechamiento. Mientras que los efectos térmicos en los esquemas de pie de presa, asociados al caudal turbinado, afectan homogéneamente a todo el tramo, en los esquemas con derivación, los efectos térmicos son diferidos, uno asociado al caudal ecológico y el otro al caudal turbinado.
Plasma presepsin for mortality prediction in patients with sepsis-associated acute kidney injury requiring continuous kidney replacement therapy
Authors: Lee Gi-Beop , Lee Ji Won , Yoon Se-Hee , Hwang Won Min , Yun Sung-Ro , Koh Dong Hoon , Park Yohan
Published: June 2024

Background: The reliability of presepsin as a biomarker of sepsis may be reduced in patients with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT). This study analyzed the utility of plasma presepsin values in predicting mortality in patients with AKI requiring CKRT, particularly those with sepsis-associated AKI. Methods: This single-center retrospective study included 57 patients who underwent CKRT, with plasma presepsin measurements, from April 2022 to March 2023; 35 had sepsis-associated AKI. The predictive values of plasma presepsin, as well as Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores, for 28-day mortality were analyzed using receiver operating characteristic curves. Multivariate Cox regression analysis was performed to identify risk factors for 28-day mortality in the sepsis-associated AKI subgroup. Results: Overall, plasma presepsin showed a lower area under the curve value (0.636; 95% confidence interval [CI], 0.491–0.781) than the APACHE II (0.663; 95% CI, 0.521–0.804) and SOFA (0.731; 95% CI, 0.599–0.863) scores did. However, in sepsis-associated AKI, the area under the curve increased to 0.799 (95% CI, 0.653–0.946), which was higher than that of the APACHE II (0.638; 95% CI, 0.450–0.826) and SOFA (0.697; 95% CI, 0.519–0.875) scores. In the multivariate Cox regression analysis, a high presepsin level was an independent risk factor for 28-day mortality in sepsis-associated AKI (hazard ratio, 3.437; p = 0.03). Conclusion: Presepsin is a potential prognostic marker in patients with sepsis-associated AKI requiring CKRT.
The role of nafamostat mesylate anticoagulation in continuous kidney replacement therapy for critically ill patients with bleeding tendencies: a retrospective study on patient outcomes and safety
Authors: Kim Taeil , Kim Dong Eon , Jo Eun Mi , Lee Yeji , Kim Da Woon , Kim Hyo Jin , Seong Eun Young , Song Sang Heon , Rhee Harin
Published: June 2024

Background: Continuous kidney replacement therapy (CKRT) is crucial in the management of acute kidney injury in intensive care units (ICUs). Nonetheless, the optimal anticoagulation strategy for patients with bleeding tendencies remains debated. This study aimed to evaluate patient outcomes and safety of nafamostat mesylate (NM) compared with no anticoagulation (NA) in critically ill patients with bleeding tendencies who were undergoing CKRT. Methods: This retrospective study enrolled 2,313 patients who underwent CKRT between March 2013 and December 2022 at the third affiliated hospital in South Korea. After applying the exclusion criteria, 490 patients were included in the final analysis, with 245 patients in the NM and NA groups each, following 1:1 propensity score matching. Subsequently, in-hospital mortality, incidence of bleeding complications, agranulocytosis, hyperkalemia, and length of hospital stay were assessed. Results: No significant differences were observed between the groups regarding the lengths of hospital and ICU stays or the incidence of agranulocytosis and hyperkalemia. The NM group showed a smaller decrease in hemoglobin levels during CKRT (–1.90 g/dL vs. –2.39 g/dL) and less need for blood product transfusions than the NA group. Furthermore, the NM group exhibited a survival benefit in patients who required transfusion of all three blood products. Conclusion: NM is an effective and safe anticoagulant for CKRT in critically ill patients, especially those requiring transfusion of all three blood products. Although these findings are promising, further multicenter studies are needed to validate them and explore the mechanisms underlying the observed benefits.
Differences in the incidence, characteristics, and outcomes of patients with acute kidney injury in the medical and surgical intensive care units
Authors: Lee Yeji , Kim Taeil , Kim Dong Eon , Jo Eun Mi , Kim Da Woon , Kim Hyo Jin , Seong Eun Young , Song Sang Heon , Rhee Harin
Published: June 2024

Background: Though acute kidney injury (AKI) is a prevalent complication in critically ill patients, knowledge on the epidemiological differences and clinical characteristics of patients with AKI admitted to medical and surgical intensive care units (ICUs) remains limited. Methods: Electronic medical records of patients in ICUs in Pusan National University Hospital and Pusan National University Hospital Yangsan, from January 2011 to December 2020, were retrospectively analyzed. Different characteristics of AKI between patients were analyzed. The contribution of AKI to the in-hospital mortality rate was assessed using a Cox proportional hazards model. Results: A total of 7,150 patients were included in this study. AKI was more frequent in medical (48.7%) than in surgical patients (19.7%), with the severity of AKI higher in medical patients. In surgical patients, hospital-acquired AKI was more frequent (51.0% vs. 49.0%), whereas community-acquired AKI was more common in medical patients (58.5% vs. 41.5%). 16.9% and 5.9% of medical and surgical patients died in the hospital, respectively. AKI affected patient groups to different degrees. In surgical patients, AKI patients had 4.778 folds higher risk of mortality (95% confidence interval [CI], 3.577–6.382; p < 0.001) than non-AKI patients; whereas in medical AKI patients, it was 1.239 (95% CI, 1.051–1.461; p = 0.01). Conclusion: While the prevalence of AKI itself is higher in medical patients, the impact of AKI on mortality was stronger in surgical patients compared to medical patients. This suggests that more attention is needed for perioperative patients to prevent and manage AKI.
Mortality of elderly patients with acute kidney injury undergoing continuous renal replacement therapy: is age a risk factor?
Authors: Kim Ji Hye , Eum Sang Hun , Kim Hyoung Woo , Min Ji Won , Koh Eun Sil , Ko Eun Jeong , Kim Hyung Duk , Chung Byung Ha , Shin Seok Joon , Yang Chul Woo , Yoon Hye Eun
Published: June 2024

Background: Whether advanced age is associated with poor outcomes of elderly patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is controversial. This study aimed to evaluate age effect and predictors for mortality in elderly AKI patients undergoing CRRT. Methods: Data of 480 elderly AKI patients who underwent CRRT were retrospectively analyzed. Subjects were stratified into two groups according to age: younger-old (age, 65–74 years; n = 205) and older-old (age, ≥75 years; n = 275). Predictors for 28-day and 90-day mortality and age effects were analyzed using multivariable Cox regression analysis and propensity score matching. Results: Urine output at the start of CRRT (adjusted hazard ratio [aHR], 0.99; 95% confidence interval [CI], 0.99–1.00; p = 0.04), operation (aHR, 0.53; 95% CI, 0.30–0.93; p = 0.03), and use of an intra-aortic balloon pump (aHR, 3.60; 95% CI, 1.18–10.96; p = 0.02) were predictors for 28-day mortality. Ischemic heart disease (aHR, 1.74; 95% CI, 1.02–2.98; p = 0.04) and use of a ventilator (aHR, 0.56; 95% CI, 0.36–0.89; p = 0.01) were predictors for 90-day mortality. The older-old group did not exhibit a higher risk for 28- day or 90-day mortality than the younger-old group in multivariable or propensity score-matched models. Conclusion: Advanced age was not a risk factor for mortality among elderly AKI patients undergoing CRRT, suggesting that advanced age should not be considered for therapeutic decisions in critically ill elderly patients with AKI requiring CRRT.
Association between systemic inflammation biomarkers and mortality in patients with sepsis-associated acute kidney injury receiving intensive care and continuous kidney replacement therapy: results from the RENERGY (REsearches for NEphRology and epidemioloGY) study
Authors: Jung Chan-Young , Jung Jiyun , Lim Jeong-Hoon , Paek Jin Hyuk , Kim Kipyo , Ban Tae Hyun , Park Jae Yoon , Kim Hyosang , Kim Yong Chul , Baek Chung Hee
Published: June 2024

Background: Identifying risk factors and improving prognostication for mortality among patients with sepsis-associated acute kidney injury (AKI) undergoing continuous kidney replacement therapy (CKRT) is important in improving the adverse prognosis of this patient population. This study aimed to compare the prognostic value of existing systemic inflammation biomarkers and determine the optimal systemic inflammation biomarker in patients with sepsis-associated AKI receiving CKRT. Methods: This multi-center, retrospective, observational cohort study included 1,500 patients with sepsis-associated AKI treated with intensive care and CKRT. The main predictor was a panel of 13 different systemic inflammation biomarkers. The primary outcome was 28-day mortality after CKRT initiation. Secondary outcomes included 90-day mortality after CKRT initiation, CKRT duration, kidney replacement therapy dependence at discharge, and lengths of intensive care unit (ICU) and hospital stays. Results: When added to the widely accepted Acute Physiology and Chronic Health Evaluation II score, platelet-to-albumin ratio (PAR) and neutrophil-platelet score (NPS) had the highest improvements in prognostication of 28-day mortality, where the corresponding increases in C-statistic were 0.01 (95% confidence interval [CI], 0.00–0.02) and 0.02 (95% CI, 0.01–0.03). Similar findings were observed for 90-day mortality. The 28- and 90-day mortality rates were significantly lower for the higher PAR and NPS quartiles. These associations remained significant even after adjustment for potential confounding variables in multivariable Cox proportional hazards models. Conclusion: Of the available systemic inflammation biomarkers, the addition of PAR or NPS to conventional ICU prediction models improved the prognostication of patients with sepsis-associated AKI receiving intensive care and CKRT.
Time-restricted feeding protects against cisplatin-induced acute kidney injury in mice
Authors: Jang Kyu Won , Kim Young Suk , Kim Min Jeong , Kim Seo Rin , Lee Dong Won , Lee Soo Bong , Kim Il Young
Published: June 2024

Background: Time-restricted feeding (TRF), devoid of calorie restriction, is acknowledged for promoting metabolic health and mitigating various chronic metabolic diseases. While TRF exhibits widespread benefits across multiple tissues, there is limited exploration into its impact on kidney function. In this study, our aim was to investigate the potential ameliorative effects of TRF on kidney damage in a mouse model of cisplatin-induced acute kidney injury (AKI). Methods: Cisplatin-induced AKI was induced through intraperitoneal injection of cisplatin into C57BL/6 male mice. Mice undergoing TRF were provided unrestricted access to standard chow daily but were confined to an 8-hour feeding window during the dark cycle for 2 weeks before cisplatin injection. The mice were categorized into four groups: control, TRF, cisplatin, and TRF + cisplatin. Results: The tubular damage score and serum creatinine levels were significantly lower in the TRF + cisplatin group compared to the cisplatin group. The TRF + cisplatin group exhibited reduced expression of phosphorylated nuclear factor kappa B, inflammatory cytokines, and F4/80-positive macrophages compared to the cisplatin group. Furthermore, oxidative stress markers for DNA, protein, and lipid were markedly decreased in the TRF + cisplatin group compared to the cisplatin group. TUNEL-positive tubular cells, cleaved caspase-3 expression, and the Bax/Bcl-2 ratio in the TRF + cisplatin group were lower than those in the cisplatin group. Conclusion: TRF, without calorie restriction, effectively mitigated kidney damage by suppressing inflammatory reactions, oxidative stress, and tubular apoptosis in a mouse model of cisplatin-induced AKI. TRF holds promise as a novel dietary intervention for preventing cisplatin-induced AKI.
HOTS-Based Science Learning Outcomes Assessment Instrument for Measuring Elementary School Learning Outcomes
Authors: Arthadewi Rara Indah , Bayu I Gede Wira , Rati Ni Wayan
Published: June 2024

Teachers should develop effective assessment instruments to measure student learning outcomes well. Assessment instruments must also improve students' thinking abilities (HOTS). However, teachers need help compiling assessment instruments based on Revised Bloom's KKO Taxonomy, and the assessment instruments prepared are still LOTS-oriented. So far, research has yet to discuss the preparation of HOTS-based science learning outcomes assessment instruments. Therefore, this research aims to develop a HOTS-oriented assessment instrument for science content. This research is development research with a 4-D model. The subjects of this research were 69 students and involved two expert lecturers/science experts. Data collection in this study used the multiple-choice test method. The data analysis techniques in this research are validity, reliability, distinguishability, level of difficulty, and quality of distractors. The results of the research show that the assessment instrument developed is declared valid, has high reliability (reliable), and the level of difficulty is in the very good category; in terms of different power, it is stated that the instrument has good different power, and the quality of the distractor functions well. The test results show that the HOTS-oriented science learning outcomes assessment instrument is suitable for measuring student learning outcomes. This research implies that continuously using the HOTS standard assessment instrument will improve students' thinking.
Trends in Climate Change Education Studies in the Last Ten Years: A Systematic Literature Review
Authors: Hadiapurwa Angga , Ali Mohammad , Ropo Eero , Hernawan Asep Herry
Published: June 2024

Climate change is a concern for all countries in the world. UNESCO is taking part in efforts to increase awareness regarding climate change, one of which is by creating the Greening Education Partnership program. Climate Change Education (CCE) is an effort in the education sector to increase students' awareness of climate change. This article attempts to analyze publication trends regarding CCE and explore other opportunities for further research on the topic of CCE. The method used is the systematic literature review (SLR) method and data analysis using bibliometrics. The data used in this research are documents published by journals on the Scopus database published in 2013-2022. In 2013-2022, 462 documents can be searched in the Scopus database with the keyword ‘climate change education’. The analysis results show that discussions about CCE related to curriculum, learning, and students have been widely studied and published. However, there is no visible academic interaction between the authors. These conditions can be the basis that CCE needs to be implemented thoughtfully to increase awareness of environmental change. Apart from that, its implementation also requires collaborative roles from each sector so that CCE implementation can be carried out optimally. There needs to be a policy to encourage implementation by integrating CCE and the curriculum. Schools and universities encourage teachers and lecturers to deliver CCE in learning by including specific topics that can be related.
Productive Competence, Internship, and Family Support on Student Work Readiness Mediated by Self-Efficacy
Authors: Cipta Grasia Kristina Adi , Wahyuni Daru
Published: June 2024

The current problem is that many vocational school graduate students still need more skills. Students' skills and readiness are influenced by many factors including productive competence, internship, and family support. This research aims to analyze the influence of perceptions of productive competence, industrial work, and family support on vocational school students' work readiness, partially or simultaneously mediated by self-efficacy. This research is causal associative research with a quantitative approach. The total population in this study was 1132 students. The sample for this research was 296 respondents. The method used to collect data is a questionnaire. The instrument used to collect data was a questionnaire. The data analysis method used is descriptive and inferential statistical analysis. The data analysis technique used is Structural Equation Modeling (SEM). The research results show that students' perceptions of productive competence, industrial work practices, family support, and self-efficacy have a positive and significant effect on students' work readiness. Based on the results of the Sobel test, Self-Efficacy can mediate the influence of productive competence, industrial work practices, and family support on vocational school students' work readiness. It was concluded that perceptions of productive competence, industrial work, and family support influenced vocational school students' work readiness. The implication of this research is that family and school support is very necessary for students so that students have good work readiness.
Formative and Summative Assessment Using Technology: A Critical Review
Authors: Onasanya Samuel Adebisi , Ajamu Adesoye Oladunni
Published: June 2024

The use of technology in the classroom has revolutionized the teaching process by giving educators more freedom and opportunities to differentiate instruction. The purpose of this research is to critically assess a variety of technological approaches that were particularly chosen for their compatibility with and ability to improve on existing assessment for learning practices. The underlying viewpoints are that (a) summative and formative evaluations are both important learning opportunities, and (b) utilizing technology can improve learning throughout evaluation and feedback processes. The research method uses Systematic Literature Review (SLR). A literature search was conducted through academic databases, such as PubMed, ERIC, and Google Scholar. The benefits and downsides of employing technology are evaluated using research from a research study through literature. It is said that the usage of various forms of technology can aid in the facilitation of efficient assessment for learning and feedback in higher education by adopting a flexible strategy and taking tiny incremental steps. In a supportive learning environment, where a staff-student approach can be particularly helpful, trust between students and staff can help innovative methods succeed.
Indonesian Sound Errors in Television Advertisements
Authors: Erwina Emmy , Syarfina Tengku , Chitra Bima Prana
Published: June 2024

Language sound errors at the phonological level. Phonemes or language sounds in Indonesian consist of vowels, consonants, diphthongs 'double vowels', and clusters 'consonant groups'. Differences in phonemes will change standard language varieties into non-standard ones. Phonological problems occur because vowel, consonant or diphthong phonemes change into other phonemes, thereby changing standard language into non-standard ones. This research aims to analyze language sound errors, namely deletions, additions and changes in vowel phonemes, consonant phonemes, combined vowel phonemes and combined consonant phonemes. This study used descriptive qualitative method. The data collection technique for this research is by listening and using the language watched in Indonesian television advertisements. This data analysis technique consists of (1) data collection (2) data reduction, (3) data presentation (4) interesting conclusions. The results of data analysis of Indonesian language sound errors in Television Advertisements are language sound errors in Indonesian consisting of vowels, consonants, diphthongs 'double vowels', and 'consonant clusters' clusters due to errors in language use that do not match Indonesian Spelling (EBI) . Errors in Indonesian sounds or pronunciation that occur in television advertisements like this occur due to ignorance or on purpose so that the advertisement displayed will attract the attention of consumers or people who see, watch and listen to it.