bluuebunny/crossref_metadata_2025 huggingface dataset:
DS 7 Crossback: Fit for a President
Authors: Pickering Chris
Published: July 2023

French luxury cars once had a reputation for being quirky, innovative and cosseting. The DS 7 Crossback seeks to bring back some of that joie de vivre
A Billion Tonnes, 150 People
Authors: Ford Jason
Published: July 2023

Automation is helping a Swiss food giant produce vast amounts of food with very little human intervention
Al System WiseEye Weaves its Magic to Detect Defects in Fabric Production
Authors: Nathan Stuart
Published: July 2023

Innovative textile production breakthrough proves as reliable for quality control as the traditional human eye process
Identification of functional genes regulating gastric cancer progression using integrated bioinformatics analysis
Authors: Yu Kun , Zhang Dong , Yao Qiang , Pan Xing , Wang Gang , Qian Hai-yang , Xiao Yao , Chen Qiong , Mei Ke
Published: July 2023

The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the constituencies needed for reform to occur. He could say what other reformers could not, due to their links to the medical education community. But now we are again going back to a pre-Flexnerian state due to multiple reasons such as gradually diminishing importance of basic science subjects for the students, the decline in the number and quality of investigator initiated research among clinical researchers, lesser emphasis to bedside training by means of detailed clinical examination and making appropriate observation of signs to reach to a diagnosis rather than over reliance on the laboratory tests and radiological modalities for the diagnosis, poor exposure to basic clinical skills starting from college throughout residency and the trend of disrespect and absenteeism from both theoretical and clinical/practical classes. The attitude of students is just to complete their required attendance so that they are not barred from appearing in examinations. This de-Flexnerization trend and regression to pre-Flexnerian era standards, ideologies, structures, processes, and attitudes, are bound to beget pre-Flexnerian outcomes, for you get what you designed for.
Clinical effects of a traditional Chinese medicine nursing programme to intervene in gastric pain of the spleen and stomach with Qi deficiency
Authors: Yu Yin-Hong , Yu Yu-Shuang , Cheng Xiao-He
Published: July 2023

The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the constituencies needed for reform to occur. He could say what other reformers could not, due to their links to the medical education community. But now we are again going back to a pre-Flexnerian state due to multiple reasons such as gradually diminishing importance of basic science subjects for the students, the decline in the number and quality of investigator initiated research among clinical researchers, lesser emphasis to bedside training by means of detailed clinical examination and making appropriate observation of signs to reach to a diagnosis rather than over reliance on the laboratory tests and radiological modalities for the diagnosis, poor exposure to basic clinical skills starting from college throughout residency and the trend of disrespect and absenteeism from both theoretical and clinical/practical classes. The attitude of students is just to complete their required attendance so that they are not barred from appearing in examinations. This de-Flexnerization trend and regression to pre-Flexnerian era standards, ideologies, structures, processes, and attitudes, are bound to beget pre-Flexnerian outcomes, for you get what you designed for.
Clinical study of acupuncture combined with surface anesthesia using proparacaine in geriatric cataract phacoemulsification
Authors: Dong Ping , Wang Li-Fang , Zhang Li-Xiang , Li Fang , Yin Hui-Su , Dou Zhi-Xia , Huang Xiu-Ju , Xu Rui , Zhang Wu-Lin
Published: July 2023

The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the constituencies needed for reform to occur. He could say what other reformers could not, due to their links to the medical education community. But now we are again going back to a pre-Flexnerian state due to multiple reasons such as gradually diminishing importance of basic science subjects for the students, the decline in the number and quality of investigator initiated research among clinical researchers, lesser emphasis to bedside training by means of detailed clinical examination and making appropriate observation of signs to reach to a diagnosis rather than over reliance on the laboratory tests and radiological modalities for the diagnosis, poor exposure to basic clinical skills starting from college throughout residency and the trend of disrespect and absenteeism from both theoretical and clinical/practical classes. The attitude of students is just to complete their required attendance so that they are not barred from appearing in examinations. This de-Flexnerization trend and regression to pre-Flexnerian era standards, ideologies, structures, processes, and attitudes, are bound to beget pre-Flexnerian outcomes, for you get what you designed for.
Acute myelomonocytic leukemia and T-lymphoblastic lymphoma as simultaneous bilineage hematologic malignancy treated with decitabine: A case report
Authors: Jeon So-Yeon , Lee Na-Ri , Cha Seungah , Yhim Ho-Young , Kwak Jae-Yong , Jang Kyu Yun , Kim Namsu , Cho Yong Gon , Lee Chang-Hoon
Published: July 2023

The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the constituencies needed for reform to occur. He could say what other reformers could not, due to their links to the medical education community. But now we are again going back to a pre-Flexnerian state due to multiple reasons such as gradually diminishing importance of basic science subjects for the students, the decline in the number and quality of investigator initiated research among clinical researchers, lesser emphasis to bedside training by means of detailed clinical examination and making appropriate observation of signs to reach to a diagnosis rather than over reliance on the laboratory tests and radiological modalities for the diagnosis, poor exposure to basic clinical skills starting from college throughout residency and the trend of disrespect and absenteeism from both theoretical and clinical/practical classes. The attitude of students is just to complete their required attendance so that they are not barred from appearing in examinations. This de-Flexnerization trend and regression to pre-Flexnerian era standards, ideologies, structures, processes, and attitudes, are bound to beget pre-Flexnerian outcomes, for you get what you designed for.
Prostatic stromal tumour of uncertain malignant potential treated with robotic-assisted radical prostatectomy: medium-term oncological and functional outcome of two cases
Authors: Dokubo II , Tay LJ , Rutigliani L , Appukutty S , Warren A , Shah N , Lamb BW
Published: July 2023

Stromal tumour of uncertain malignant potential (STUMP) is a rare tumour of the prostate with variable and unpredictable risk and clinical progression. There is no clear consensus on how it should be managed. We describe two cases of patients who presented to their general practitioners with raised prostate-specific antigen in one instance and an abnormal digital rectal examination in the other. Biopsies were carried out and a diagnosis of STUMP was made. Both cases were managed with robot-assisted radical prostatectomy and after 4.8 years of follow-up, there has not been any recurrence. This is the first reported UK case in which STUMP has been successfully managed with robotic surgery with excellent medium-term results. Radical prostatectomy can be used to treat STUMP tumour with good oncological and functional outcomes.
"Marrying Her Husband's Son": Locke, the Politics of Sexual Morality, and the Case of Incest at the Church at Corinth
Authors: Smith Brian
Published: July 2023

abstract: This paper explores the tension between the role the magistrate plays in Locke's letters on toleration and the theory of sexual morality he develops in his analysis of the case of incest at the church at Corinth in his "Paraphrases" on Paul's Epistles. A son had married his father's ex-wife, a practice decried as "heinous" by seventeenth-century commentators. Contrary to the political uses of this case by members of the Anglican Church, Locke argues that moral communities should police themselves through private censure. At first glance, this sits uncomfortably with the view that the magistrate should punish adulterers and those who engage in "heinous enormities." This paper seeks to reconcile these two visions by showing how the incentive structure of the civil law was meant to supplement the maximalist moral commitments of the religious communities that make up society.
Refined Sellmeier equations for AgGaS2 down to 0.565  µm
Authors: Kato Kiyoshi , Petrov Valentin , Miyata Kentaro
Published: July 2023

We revisit the 90° phase-matching conditions for second-harmonic, sum-frequency, and difference-frequency generation in AgGaS2 thus far reported in the literature. We present refined Sellmeier equations coupled with an updated thermo-optic dispersion formula to correctly reproduce the experimental results for noncritical three-wave interactions obtained in the 0.565–10.5910 µm spectral range.
Adaptive anisotropic pixel-by-pixel correction method for a space-variant degraded image
Authors: Hong Hanyu , Zuo Zhichao , Shi Yu , Hua Xia , Xiong Lun , Zhang Yaozong , Zhang Tianxu
Published: July 2023

Large field-of-view optical imaging systems often face challenges in the presence of space-variant degradation. The existence of degradation leads to target detection and recognition being difficult or even unsuccessful. To address this issue, this paper proposes an adaptive anisotropic pixel-by-pixel space-variant correction method. First, we estimated region acquisition of local space-variant point spread functions (PSFs) based on Haar wavelet degradation degree distribution, and obtained initial PSF matrix estimation with inverse distance weighted spatial interpolation. Then, we established a pixel-by-pixel space-variant correction model based on the PSF matrix. Third, we imposed adaptive sparse regularization terms of the Haar wavelet based on the adaptive anisotropic iterative reweight strategy and non-negative regularization terms as the constraint in the pixel-by-pixel space-variant correction model. Finally, as the correction process is refined to each pixel, the split-Bregman multivariate separation solution algorithm was employed for the pixel-by-pixel spare-variant correction model to estimate the final PSF matrix and the gray value of each pixel. Through this algorithm, the “whole image correction” and “block correction” is avoided, the “pixel-by-pixel correction” is realized, and the final corrected images are obtained. Experimental results show that compared with the current advanced correction methods, the proposed approach in the space-variant wide field correction of a degraded image shows better performance in preserving the image details and texture information.
Photonic generation of multi-format chirped signals with a high switching rate
Authors: Guo Yuxiao , Wang Muguang , Li Yan , Wang Jian , Chen Desheng
Published: July 2023

A novel photonic method for multi-format chirped signal generation with a high switching rate based on a dual-polarization binary phase shift keying (DP-BPSK) modulator is proposed and demonstrated. An up-chirp signal and a binary code signal are used to drive one of the sub-dual-drive Mach–Zehnder modulators (sub-DDMZMs) integrated in the DP-BPSK modulator. Another integrated sub-DDMZM is driven by a down-chirp signal and another binary code signal. By carefully tuning the DC biases of the DP-BPSK modulator, the format of the output chirped signal is controlled by the binary code signals. A proof-of-concept experiment is performed and multi-format chirped signals with a high switching rate are generated. Due to the high switching rate, simple structure, and high adjustability, the proposed multi-format chirped signal generator may find potential applications in multifunctional radar systems, wireless communication systems, and dual-function radar-communication systems.
Use of machine learning methods to understand discussions of female genital mutilation/cutting on social media
Authors: Babbs Gray , Weber Sarah E. , Abdalla Salma M. , Cesare Nina , Nsoesie Elaine O.
Published: July 2023

Female genital mutilation/cutting (FGM/C) describes several procedures that involve injury to the vulva or vagina for nontherapeutic reasons. Though at least 200 million women and girls living in 30 countries have undergone FGM/C, there is a paucity of studies focused on public perception of FGM/C. We used machine learning methods to characterize discussion of FGM/C on Twitter in English from 2015 to 2020. Twitter has emerged in recent years as a source for seeking and sharing health information and misinformation. We extracted text metadata from user profiles to characterize the individuals and locations involved in conversations about FGM/C. We extracted major discussion themes from posts using correlated topic modeling. Finally, we extracted features from posts and applied random forest models to predict user engagement. The volume of tweets addressing FGM/C remained fairly stable across years. Conversation was mostly concentrated among the United States and United Kingdom through 2017, but shifted to Nigeria and Kenya in 2020. Some of the discussion topics associated with FGM/C across years included Islam, International Day of Zero Tolerance, current news stories, education, activism, male circumcision, human rights, and feminism. Tweet length and follower count were consistently strong predictors of engagement. Our findings suggest that (1) discussion about FGM/C has not evolved significantly over time, (2) the majority of the conversation about FGM/C on English-speaking Twitter is advocating for an end to the practice, (3) supporters of Donald Trump make up a substantial voice in the conversation about FGM/C, and (4) understanding the nuances in how people across cultures refer to and discuss FGM/C could be important for the design of public health communication and intervention.
Evaluation of China’s provincial digital economy development level and its coupling coordination relationship
Authors: Lin Kongtuan , Zhang Xuanhao , Hou Jie
Published: July 2023

Based on the Office for National Statistics’ delineation of the scope of the digital economy industry, this paper selects indicators from five industrial dimensions: digital product manufacturing, digital product service, digital technology application, digital factor drive and digital efficiency improvement, and constructs an evaluation system to measure the development level of China’s digital economy at the provincial level. It is found that there is a wide gap in the development of China’s provincial digital economy, with the eastern coastal provinces and cities having a high level of digital economy development. The coupling and coordination model was then applied to examine the interrelationships between the five industrial dimensions of the digital economy, and it was found that most of the coupling and coordination relationships of the five industrial dimensions are at the stage of medium-high coupling and low coupling and coordination, and each province and city has different coupling and coordination characteristics. The numerical evaluation results provide an intuitive understanding of the differences and deficiencies in the development of the digital economy in different regions, and serve as a reference for the medium and long-term digital economy development planning of provinces and municipalities as well as the whole country. In the future, the state should invest more in the digital economy in the central and western regions, and each province should cultivate and develop the digital economy in accordance with its own local conditions.
Immune marker reductions in black and white Americans following sleeve gastrectomy in the short-term phase of surgical weight loss
Authors: Phillips Charles L. , Le Tran T. , Lirette Seth T. , Welch Bradley A. , Glover Sarah C. , Dungey Adam , Vick Kenneth D. , Grayson Bernadette E.
Published: July 2023

Background

Surgical weight loss procedures like vertical sleeve gastrectomy (SG) are sufficient in resolving obesity comorbidities and are touted to reduce the burden of pro-inflammatory cytokines and augment the release of anti-inflammatory cytokines. Recent reports suggest a reduced improvement in weight resolution after SG in Black Americans (BA) versus White Americans (WA). The goal of this study was to determine if differences in immunoglobulin levels and general markers of inflammation after SG in Black Americans (BA) and White Americans (WA) may contribute to this differential resolution.

Methods

Personal information, anthropometric data, and plasma samples were collected from 58 participants (24 BA and 34 WA) before and 6 weeks after SG for the measurement of immunoglobulin A (IgA), IgG, IgM, C-reactive protein (CRP), and transforming growth factor (TGFβ). Logistic regression analysis was used to determine the relationship of measures of body size and weight and inflammatory markers.

Results

Both IgG and CRP were significantly elevated in BA in comparison to WA prior to weight loss. Collectively, IgG, TGFβ, and CRP were all significantly reduced at six weeks following SG. CRP levels in BA were reduced to a similar extent as WA, but IgG levels were more dramatically reduced in BA than WA despite the overall higher starting concentration. No change was observed in IgA and IgM.

Conclusions

These data suggest that SG improves markers of immune function in both BA and WA. More diverse markers of immune health should be studied in future work.
α7 nicotinic acetylcholine receptor interaction with G proteins in breast cancer cell proliferation, motility, and calcium signaling
Authors: Oz Murat , King Justin R. , Yang Keun-Hang Susan , Khushaish Sarah , Tchugunova Yulia , Khajah Maitham A. , Luqmani Yunus A. , Kabbani Nadine
Published: July 2023

Chronic smoking is a primary risk factor for breast cancer due to the presence of various toxins and carcinogens within tobacco products. Nicotine is the primary addictive component of tobacco products and has been shown to promote breast cancer cell proliferation and metastases. Nicotine activates nicotinic acetylcholine receptors (nAChRs) that are expressed in cancer cell lines. Here, we examine the role of the α7 nAChR in coupling to heterotrimeric G proteins within breast cancer MCF-7 cells. Pharmacological activation of the α7 nAChR using choline or nicotine was found to increase proliferation, motility, and calcium signaling in MCF-7 cells. This effect of α7 nAChR on cell proliferation was abolished by application of Gαi/o and Gαq protein blockers. Specifically, application of the Gαi/o inhibitor pertussis toxin was found to abolish choline-mediated cell proliferation and intracellular calcium transient response. These findings were corroborated by expression of a G protein binding dominant negative nAChR subunit (α7345-348A), which resulted in significantly attenuating calcium signaling and cellular proliferation in response to choline. Our study shows a new role for G protein signaling in the mechanism of α7 nAChR-associated breast cancer growth.
The respiratory syncytial virus M2-2 protein is targeted for proteasome degradation and inhibits translation and stress granules assembly
Authors: Scudero Orlando Bonito , Santiago Verônica Feijoli , Palmisano Giuseppe , Simabuco Fernando Moreira , Ventura Armando Morais
Published: July 2023

The M2-2 protein from the respiratory syncytial virus (RSV) is a 10 kDa protein expressed by the second ORF of the viral gene M2. During infection, M2-2 has been described as the polymerase cofactor responsible for promoting genome replication, which occurs by the induction of changes in interactions between the polymerase and other viral proteins at early stages of infection. Despite its well-explored role in the regulation of the polymerase activity, little has been made to investigate the relationship of M2-2 with cellular proteins. A previous report showed poor recruitment of M2-2 to viral structures, with the protein being mainly localized to the nucleus and cytoplasmic granules. To unravel which other functions M2-2 exerts during infection, we performed proteomic analysis of co-immunoprecipitated cellular partners, identifying enrichment of proteins involved with regulation of translation, protein folding and mRNA splicing. In approaches based on these data, we found that M2-2 expression downregulates eiF2α phosphorylation and inhibits both translation and stress granules assembly. Finally, we also verified that M2-2 is targeted for proteasome degradation, being localized to granules composed of defective ribosomal products at the cytoplasm. These results suggest that besides its functions in the replicative complex, M2-2 may exert additional functions to contribute to successful RSV infection.
Clinical, laboratory, and molecular epidemiology of Orientia tsutsugamushi infection from Southwestern India
Authors: Chunduru Kiran , A. R. Manoj , Poornima Subhadra , Hande H. Manjunatha , M Mridula , Varghese George M. , Devaki Ramakrishna , Saravu Kavitha
Published: July 2023

Scrub typhus is a vector borne disease which in a proportion of patients causes multiorgan involvement and death if untreated. Infecting genotype and virulence factors play a role in severity of infection and outcome. The current prospective cohort study was undertaken to elucidate the severity of illness in scrub typhus patients and to identify the circulating genotypes in Karnataka, India. A total of 214 patients of either gender from 9 districts of Karnataka and one patient each from Andhra Pradesh and Kerala, India were enrolled in the study. With a predefined severity criterion, 132 patients were segregated to the severe group. Multi organ involvement was seen in 59 (44.69%) patients. Phylogenetic analysis revealed JG-v like (48.97%), Karp-like (26.53%), JG-like (22.44%), and Kato-like (2.04%) strains in Karnataka. Patients infected withOrientia tsutsugamushiKarp-like strains had respiratory involvement (69.2%), cardiovascular involvement (46.2%) and thrombocytopenia (23.1%) and required higher hospital resource utilization.
Machine Learning based analysis of users’ online behaviour
Authors: Kőrösi Gábor
Published: July 2023

Mind a vásárlásról és a tanulásról is elmondható, hogy néhány évvel ezelőtt, még szinte teljesen kizárólag a hagyományos offline formátumban zajlottak, addig ez mára jelentősen megváltozott. Ez a változás új kihívások elé állítja a területen dolgozó szakembereket, hiszen a legtöbb hagyományos módszer és módszertanok nagy része teljesen elavulttá és működésképtelenné vált az online térben. Ezek a szerepekörök eltűnése azonban nem maradt észrevétlen, mivel számos online vállalkozás küzd a csökkenő ügyfélszámmal, és az online tanulási rendszerek is csupán gyenge hatékonysággal képesek működni. Bár tagadhatatlan, hogy az online jelenlét jelentős kihívásokat teremtett az üzleti és oktatási vezetők számára, ugyanakkor új lehetőségeket is megnyitott. A különböző online platformok rengeteg naplóadattal rendelkeznek, mely teret biztosít az adattudományi szakemberek bevonására, akik kepések gépi tanuláson alapuló online felhasználói viselkedés elemzése. Az elemzések egyik legfontosabb eszköze maguk log adatokat, melyek többfélék lehetnek. Ez a kutatási terület nem újkeletű, hiszen a felhasználói naplóadatok elemzésével kapcsolatban már több, mint tizenöt éve folyik aktív kutatás. A szakirodalmi áttekintése alapján megállapítható, hogy az egyik leggyakoribb megoldás az, amelyben magas-középszintű naplóadatok felhasználásával aggregált adatbázisokat, úgynevezett felhasználói profilokat hoznak létre. Ezeket később osztályozásra, regresszióra vagy akár klaszterezésre használják fel. S bár a kutatások régóta folynak, ám az utóbbi időben a felhasznált módszerek valamelyest megváltoztak. Még kezdetben a kutatás legnagyobb hányada kumulált, előfeldolgozott adatokkal dolgozott, mára új technológiai megoldások kerültek előtérbe. E fejlődésnek köszönhetően a korábban hagyományos jellemzők kinyeréseit és a gépi tanulási módszereket mára felváltották a Deep Learning-en alapuló megoldások. Ezek egyik nagy ígérete, hogy a nagy mennyiségű adatra is képesek magas minőségű megoldásokat nyújtani, és kepések akár nyers alacsony szintű adatokból kiindulva is dolgozni. A disszertáció összesen 7 fejezetet tartalmaz, amelyek a fent említett megközelítéseket felhasználó különálló tanulmányokból állnak. Az első két fejezetben a szerző bemutatja a naplóadatok gyűjtésének és előkészítésének speciális kihívásait a magas szintű naplóadatbázisokon. Továbbá bemutatja az előjelzési megoldásainak eredményeit egy valós magyar webshop adatbázisán. Emellett betekintést enged a Szegedi Tudományegyetem két tanszékének együttműködéseként kifejlesztett és elindított "Tudatos és biztonságos internethasználat" (TÉBIA) című MOOC kurzusán végzett kísérleteibe.
Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators
Authors: Arayangkool Chinnawat , Gozun Maan , Tanariyakul Manasawee , Techasatian Witina , Leesutipornchai Thiratest , Nishimura Yoshito
Published: July 2023

Selective androgen receptor modulators (SARMs) are novel nonsteroidal agents abused for performance enhancement such as anabolic steroids. We report a case of a 27-year-old man who used 3 different SARMs and presented with progressive weakness. Initial laboratory testing showed kidney and liver injury with creatinine 4.8 mg/dL and total bilirubin 43.3 mg/dL. An extensive workup was negative for other causes, and the results of liver and kidney biopsies were consistent with bile cast nephropathy because of SARM-associated drug-induced liver injury. His organ functions improved with the cessation of SARMs and plasmapheresis. Providers need to recognize the extreme consequences of SARM use.
The diagnostic value of fluorescence in situ hybridization in secondary electroresection of bladder cancer
Authors: Chen Bowen , Shu Bo , Liu Zhenghao , Zhu Junyu , Ke Chunjin , Zeng Xing , Hu Zhiquan , Yang Chunguang
Published: July 2023

OBJECTIVE: To investigate the utility of fluorescence in situ hybridization (FISH) in secondary electroresection of bladder cancer. METHODS: From January 2016 to April 2022, bladder cancer patients who had undergone secondary electroresection in Tongji Hospital and had preoperative urine FISH were recruited, and the positive rate, accuracy, sensitivity, specificity, genetic material changes and predictive power on malignancy degree of FISH in the secondary electroresection of bladder cancer were examined. RESULTS: Twenty-six patients with bladder cancer were included in this study, and 8 were confirmed by secondary electroresection, including 6 cases positive for FISH positive and 2 negative for FISH. Besides, among the subjects, 18 were without tumor recurrence, including 1 case with positive FISH results and 17 with negative FISH results. Tumor recurrence was diagnosed in 85.71% (6/7) of FISH-positive patients in secondary electroresection while only 10.53% (2/19) of FISH-negative patients were found to develop tumor recurrence in the secondary electroresection. The sensitivity of FISH for the detection of bladder cancer before secondary electroresection was 75%, with a specificity of 94.44%, and an accuracy of 88.46%. A 6-month follow-up revealed that 2 of the 8 recurrent patients underwent radical resection of bladder cancer, and the remaining 6 patients had no recurrence, as confirmed by regular bladder perfusion and microscopy. In the 18 non-recurrent patients during secondary electroresection, no recurrence developed.CONCLUSIONS: Urine FISH can achieve a high detection rate and specificity for secondary electroresection of bladder cancer. If a bladder cancer patient who are indicated for secondary electroresection is negative for urine FISH, the recurrence rate after secondary electroresection will be low, and the cystoscopy can be performed before deciding whether to perform secondary electroresection.
Humanökologische Thesen für eine Wende in der Pandemieforschung: Eine personzentrierte, ökosystemische Gesundheitsforschung und -praxis ist nötig!
Authors: Tretter Felix , Simon Karl-Heinz
Published: July 2023

Die Corona-Pandemie hat vor Augen geführt, dass die inter- und transdisziplinäre Wissensproduktion verbessert werden muss. Es braucht eine ganzheitliche systemische Perspektive, die ,,den individuellen Menschen“ wieder ins Zentrum rückt. In sechs Thesen wird aus
humanökologischer Perspektive formuliert, wie die Pandemieforschung neu auszurichten ist. Diese Thesen sind Resultat von Meetings und Publikationen, geleitet von Felix Tretter, die sich aus wissenschaftsphilosophischer Perspektive mit der Methodik der Wissensproduktion der medizinischen
Corona-Wissenschaft befassten.
Sozial-ökologische Transformation mit dem Deutsch-Französischen Zukunftswerk: transnational, transdisziplinär, bottom-up
Authors: Plessing Julia , Ameskamp Konstanze
Published: July 2023

Durch deutsch-französischen Dialog die sozial-ökologische Transformation auf kommunaler Ebene voranzubringen, das ist das Anliegen des Deutsch-Französischen Zukunftswerks. Denn Fragen des Klimaschutzes, der Resilienz und der nachhaltigen Stadtentwicklung stellen sich
transnational. Und auf beiden Seiten der Grenze ist es den Kommunen wichtig, zentralstaatliche Barrieren abzubauen und eine effektive Förderung einzufordern. Darüber hinaus gibt es viele Ansatzpunkte, bei Fragen des täglichen transformativen Handelns voneinander zu lernen und
zu profitieren.
Why hydrogen’s carbon past matters for hydrogen futures
Authors: Hollenhorst Johannes
Published: July 2023

Recent calls for critical social science research on hydrogen have largely focused on “green” hydrogen produced from renewable energy sources. What these calls have not fully considered is that hydrogen is a substance that has been used and produced at scale by hydrocarbon industries for decades. The fossil-based knowledge, technology, and infrastructure of this carbon past remain at the heart of the future hydrogen economy, as exemplified by the socially and environmentally problematic rise of “blue” hydrogen. To achieve a socio-ecological hydrogen transition, social science research on hydrogen needs to start from hydrogen’s carbon past in order to identify and contribute to the active reworking of hydrocarbon path dependencies.
Participatory modelling: Participatory research methods for sustainability ‐ toolkit #6
Authors: Martin Romina , Sanga Udita
Published: July 2023

Sustainability challenges require the integration of diverse knowledge types for understanding and managing social-ecological systems. Participatory modelling includes the active involvement of stakeholders in the design, development, and use of models addressing sustainability and
natural resource management challenges. Participatory modelling has the potential to support learning and co-production of knowledge, and aid in processes of deliberations, decision-making, collective management, and social learning.
Zpráva z International Legal History Meeting of PhD Students
Authors: Dvorský Václav
Published: July 2023

Report from the International Legal History Meeting of PhD Students
Exempla in the Tenth Book of Correspondence between Pliny the Younger and Emperor Trajan – Introductory Remarks
Authors: Leraczyk Izabela
Published: July 2023

The correspondence between Pliny the Younger and Emperor Trajan provides examples of legal issues which Pliny had to face as an imperial magistrate sent to the province of Bithynia and Pontus by the emperor. The aim of the article is to determine the way in which the authors of the correspondence address the question of precedents. The present work concentrates on all the instances where the concept of exemplum was used expressis verbis and on the way in which the authors of the letters referred to their preservation, eradication or creation.
Finnish-Hungarian International Law Enforcement Cooperation between the Two World Wars
Authors: Sallai János , Szabolcs Mátyás
Published: July 2023

As a result of the Industrial Revolution and civic development, the cultural, economic, and professional relationship between states grew steadily. These were based on common interests and historical, friendly relations. At the same time, crime has become international. One reason for this is that criminals, fearing prosecution, tried to hide in neighbouring states. The most effective action against this was international law enforcement cooperation. Collaborations began in the late 19th century when international criminal congresses were organized. As a result, international law enforcement relations between the countries have deepened, and professional relations have developed. The establishment of Hungarian-Finnish police relations was facilitated by the historical friendship between the two countries, the linguistic kinship, and the fact that, although in different ways, the police of both countries had almost similar tasks and problems.
La reforma rural y el problema de la distribución desigual de la tierra en Colombia
Authors: Tejedor Estupiñán Joan Miguel
Published: July 2023

Con una superficie que cubre 1,14 millones de kilómetros cuadrados, Colombia es el cuarto país más grande de América del Sur. Con alrededor del 14% de la biodiversidad del mundo, es una de las naciones con mayor diversidad ecológica. Numerosos recursos de agua dulce, la sexta área de bosque primario más grande del mundo, principalmente en la cuenca del Amazonas, y una amplia gama de recursos minerales se encuentran entre los abundantes recursos naturales de Colombia. Es el tercer mayor productor de café del mundo y sus secciones costeras albergan un número cada vez mayor de palmeras africanas.La población de Colombia es 68% urbana y 32% rural. Cerca de cincuenta millones de personas viven en Colombia; en 2021, casi el 20% de la población colombiana vivía en el sector rural (World Bank, 2021). La concentración de la propiedad de la tierra en Colombia se encuentra entre las más altas del mundo y solo es superada por Paraguay, en América Latina, en términos de desigualdad en la distribución de la tierra. El conflicto armado interno que atraviesa la nación desde hace más de setenta años ha causado y resultado en la desigualdad en el acceso a la tierra, íntimamente ligada a la pobreza rural (OXFAM International, 2013).
“Stay at home (if you can)”: informal employment and COVID-19 in Mexico
Authors: Chapa Cantú Joana Cecilia , Saldaña Villanueva Carlos Emmanuel , Luna Domínguez Edgar Mauricio
Published: July 2023

This paper explores the relationship between residential confinement to reduce the spread of the COVID-19 virus, seen as a public policy, and how it affects the informal labor sector, as well as the responseof individuals to the pandemic in the states of Mexico. Forming panels for various levels of informality applied to panel vector auto-regressive (PVAR) shows that staying at home as public policy becomes more effective as informality decreases. In addition, the response of individuals to an increase in the spread of the pande-mic depends on the level of informality: for states with lower rates of informality, individuals respond to a higher concentration of residential confinement. But for states with a higher level of informality, the evidence is not significant. The paper considers the role of informality in the development of an effective public policy.
Does chronic oral contraceptive use detrimentally affect C‐reactive protein or iron status for endurance‐trained women?
Authors: Badenhorst C. E. , Govus A. D. , Mündel T.
Published: July 2023

Purpose

Chronic use of the oral contraceptive pill (OCP) is reported to increase C‐reactive protein (CRP) levels and increase the risk of cardiovascular disease in premenopausal females.

Methods

A secondary analysis of data from two research studies in eumenorrheic (n = 8) and OCP (n = 8) female athletes. Basal CRP and iron parameters were included in the analysis. Sample collection occurred following a standardized exercise and nutritional control for 24 h. Eumenorrheic females were tested in the early‐follicular and mid‐luteal phases, and the OCP users were tested in quasi‐follicular and quasi‐luteal phases (both active pill periods).

Results

A main effect for group (p < 0.01) indicated that average CRP concentration was higher in OCP users compared with eumenorrheic females, regardless of the day of measurement within the cycle. Results demonstrate a degree of iron parameters moderation throughout the menstrual cycle that is influenced by basal CRP levels; however, no linear relationship with CRP, serum iron, and ferritin was observed.

Conclusions

Basal CRP values were consistently higher in the OCP group despite participants being in a rested state. These results may indicate a potential risk of cardiovascular disease in prolonged users of the OCP when compared to eumenorrheic female athletes.
Obfuscation of Quality Information for Dual Bounded Rational Consumers
Authors: Kumagae Keiki , Hosoe Moriki
Published: July 2023

We study the incentives for firms’ obfuscation strategies and their impact on social welfare in a market with boundedly rational consumers. We assume that firms obfuscate product information, which can prevent consumers from acquiring type information. Some naive consumers in the markets exhibited limited comprehension and default bias toward higher-quality products. We show that firms chose obfuscation in all cases except those in which consumers have a strong degree of bounded rationality and more pessimistically evaluate themselves as the naive type. This means that for firms, the benefits from second-degree price discrimination are limited and obfuscation may be a more important strategy than informing. We also find that, under certain conditions, obfuscation may result in socially desirable product allocation. This result indicate that careful consideration needs to be given to policies that reduce the incentive for firms to obfuscate, such as increasing the proportion of sophisticated consumers.
Hallazgo incidental de una hemoglobina rara: hemoglobina Bari en el noreste de España
Authors: Lahoz Alonso Raquel , Romero Sánchez Naiara , González Sánchez Ruth , Escobar Medina Antonia , López Martos Aurora M. , Domínguez García Marta , Beneitez Pastor David , Prieto Grueso Montserrat , Blanco Álvarez Adoración , Urban Giralt Susana , Esteve Alcalde Patricia
Published: July 2023

Objetivos

La cromatografía líquida de alta resolución (HPLC) es una de las técnicas empleadas para determinar la hemoglobina glicosilada (HbA1c) y el método de elección para el cribado de hemoglobinopatías estructurales. El objetivo de este caso es mostrar cómo en un análisis de rutina de HbA1c es posible encontrar incidentalmente una hemoglobinopatía.

Caso clínico

En un análisis clínico rutinario, se observó un valor anormal de hemoglobina A2 (HbA2) en el análisis de HbA1c mediante HPLC, realizado con el analizador ADAMS™ A1c HA-8180T. Ante la sospecha de la presencia de una hemoglobinopatía, se amplió el estudio a posibles variantes mediante electroforesis y HPLC, empleando los analizadores Hydrasys y Variant II, respectivamente. Dado que no se pudo identificar con ninguno de los métodos tradicionales, se realizó también un estudio genético mediante secuenciación Sanger. El paciente presentaba niveles bajos de HbA2
(1.3%) y una variante del 24,9% con un tiempo de retención de 1.95 minutos, compatible con una variante de la cadena de alfa-globina. En el estudio genético, se detectó la variante patogénica c.138C>G en el gen HBA2 en heterocigosis, causando la expresión de la hemoglobinopatía conocida como hemoglobina Bari.

Conclusiones

El cribado inicial de hemoglobinopatías estructurales permite su identificación o suscita sospecha de su presencia, especialmente cuando se realiza junto al análisis de HbA1c, requiriendo posterior confirmación y diagnóstico con otras técnicas.
Plato onSunaitia
Authors: Campbell Douglas R.
Published: July 2023

I argue that Plato thinks that asunaitionis a mere tool used by a soul (or by the cosmicnous) to promote an intended outcome. In the first section, I develop the connection betweensunaitiaand Plato’s teleology. In the second section, I argue thatsunaitiabelong to Plato’s theory of the soul as a self-mover: specifically, they are those things that are set in motion by the soul in the service of some goal. I also argue against several popular and long-standing interpretations, namely, thatsunaitiacorrespond to Aristotle’s idea of hypothetical necessity, thatsunaitiaare the ‘how’ in an explanation (whereas the true cause is the ‘why’), and that Plato’s causal views should be read through Aristotle’s fourfold schema. I conclude the article by surveying the history ofsunaitiaafter Plato’s usage.
Varieties of Borel subalgebras for the Jacobson–Witt Lie algebras
Authors: Ou Ke , Shu Bin
Published: July 2023

LetW⁢(n){W(n)}be the Jacobson–Witt algebra over algebraic closed field𝕂{\mathbb{K}}with characteristicp>2{p>2}. In [K. Ou and B. Shu, Borel subalgebras of restricted Cartan-type Lie algebras, J. Algebra Appl. 21 2022, 11, Paper No. 2250210], we introduced the so-called B-subalgebra ofW⁢(n){W(n)}, which serves as an analog of the Borel subalgebra of classical Lie algebras. As a sequel, we describe the structure of the varietyℬ{\mathcal{B}}consisting of all B-subalgebras ofW⁢(n){W(n)}in this paper. This variety presents an analog of the flag variety for classical Lie algebras. It is shown thatℬ{\mathcal{B}}is related to the variety of all full flags in𝕂n+1{\mathbb{K}^{n+1}}. Additionally, we provide a detailed description of the varieties forW⁢(1){W(1)}as an illustrative example. With the above setting-up, one may establish the Springer theory and geometric representations for the Jacobson–Witt algebras.
A generalization of the canonical commutation relation and Heisenberg uncertainty principle for the orbital operators
Authors: Ugulava Duglas , Zarnadze David
Published: July 2023

In this paper, the orbits of observable physical quantities of position and momentum operators at the states of quantum Hilbert spaces are created. Also the Hilbert space of finite orbits and the Fréchet–Hilbert space of all orbits are created and the orbital operators corresponding to these observable operators in these spaces of orbits are defined and studied. We call this process the orbitization, and the obtained model the orbital quantum mechanics. The orbitization process is compared with the quantization process. The generalization of well-known canonical commutation relations for orbital operators corresponding to the position and momentum operators is established. Also, the Heisenberg uncertainty principle for the orbital operators is proved and the question of achieving equality in the Heisenberg inequality is considered.
Synthesis and characterization of ZnO/β-cyclodextrin/nicotinic acid nanocomposite and its biological and environmental application
Authors: Alqahtani Mohammed S. , Syed Rabbani , Shahid Mudassar , Shaik Jilani Purusottapatnam
Published: July 2023

In the present work, the disk-shaped zinc oxide (ZnO) nanoparticles were synthesized and functionalized with β-cyclodextrin (β-CD) and nicotinic acid (vitamin B3) using the wet co-precipitation method. The functionalized ZnO/β-CD/nicotinic acid nanocomposite materials were characterized using UV-visible spectroscopy (UV-Vis), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), field emission electron microscopy (FESEM), and band-gap energy analysis. The band gap value (E
g) was 4.3 eV. The average XRD crystallite size was determined using the Scherrer formula and was found to be 50 nm. The ZnO/β-CD/nicotinic acid nanocomposite material showed a photocatalytic effect for dye-polluted wastewater. It also showed an antibacterial effect against the Gram-positive bacterial strain Streptococcus aureus (S. aureus) but did not show any antibacterial activity with Gram-negative Escherichia coli (E. coli). The ZnO/β-CD/nicotinic acid nanocomposite also showed antifungal activity with Aspergillus niger (A. niger). It was noticed that ZnO/β-CD/nicotinic acid nanocomposite showed efficient anticancer activity with IC50 = 14.95 µg·mL−1 in MCF-7 cell lines. Because of the formation of singlet oxygen (O2˙−) and hydrogen oxide radical (–OH˙), the composite material showed a photodegradation reaction against aq. solution of methylene blue dye. After 190 min, the blue colour of aq. solution methylene blue was decolourized at 6 pH at a constant time interval.
Retrospective comparison of monochorionic diamniotic twin pregnancies stratified by spontaneous or artificial conception
Authors: Roero Sofia , Arduino Silvana , Arese Arianna , Fea Teresa , Ferrando Isabella , Scaltrito Gabriella , Casula Viola , Ronco Alice , Bossotti Carlotta , Zizzo Roberto , Scali Roberto , Revelli Alberto
Published: July 2023

Objectives

To compare outcomes of monochorionic diamniotic (MCDA) twin pregnancies by in vitro fertilization (IVF) vs. spontaneously conceived counterparts.

Methods

Retrospective comparison. Data about MCDA twin pregnancies, conceived spontaneously or by IVF, attending the Twin Pregnancy Care Unit of Sant’Anna Hospital in Turin (Italy) between January 1st 2010 and March 31st 2022, were collected retrospectively. Obstetric, fetal, and neonatal outcomes of MCDA twin pregnancies by IVF were compared to those of spontaneously conceived counterparts. Data were described by univariate and multivariate analysis.

Results

541 MCDA twin pregnancies were included in the study, among which 45 conceived by IVF and 496 spontaneously conceived. Women with IVF twins were older than those who conceived spontaneously (36.7 ± 5.7 vs. 32.1 ± 5.2 years; p<0.001). No significant difference in the prevalence of pregnancy complications between the two groups was found, except for an increased incidence of hypertensive disorders among IVF pregnancies (17.8 vs. 8.5 %; p=0.039), which resulted nonsignificant after adjusting for maternal age and parity (aOR 1.9, 95 % CI 0.8–4.6). Data about 1,046 live born babies (90 conceived by IVF and 956 spontaneously) were also collected: perinatal outcomes did not differ between the two groups.

Conclusions

Our results suggest that MCDA twin pregnancies following IVF are not at increased risk of adverse outcomes compared to spontaneous MCDA twin pregnancies.