bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychometric properties of the Mexican version of the Intolerance of Uncertainty Scale: The IUS-12M
Authors: Hernández-Posadas Alejandrina , De la Rosa-Gómez Anabel , Lommen Miriam J. J. , Bouman Theo K. , Mancilla-Díaz Juan M. , Del Palacio González Adriana
Published: January 2024

Background: The Intolerance of Uncertainty Scale short version (IUS-12) has proven to be a robust self-report measure to assess intolerance of uncertainty. While previous psychometric analyses of the IUS-12 have established a stable two-factor structure corresponding to the prospective and inhibitory factors of intolerance of uncertainty, recent studies suggest that the bifactor model may better explain its factor structure. Objective: The current study aimed to adapt and validate the IUS-12 in a Mexican population culturally. Method: The study consisted of a convenience non-probabilistic community sample of 405 adults between 18 and 70 years. Results: Confirmatory factor analyses supported a bifactor model and good internal consistency. Invariance testing indicated partial invariance across women and men. Convergent validity tests showed that the IUS-12 was related to measures of worry, as well as depression and anxiety. Conclusion: These findings provide evidence for the reliability and validity of the adapted version of the IUS-12 in Mexico.
Developing and Validating E-Learning Module for Islamic Higher Education Digital Literacy in Preventing Hoax (EMODILPH)
Authors: Masykur Ruhban , Irwandani Irwandani , Aridan Muhammad , Susilowati Nur Endah , Soeharto Soeharto
Published: January 2024

The digital literacy curriculum in universities, especially Islamic universities, needs to be developed intensively to respond to the rapid exposure of hoax news among students. Therefore, this study aims to develop an e-module for digital learning and to investigate how this product can be implemented in a digital literacy curriculum model at Islamic universities. The Rasch measurement was used to assess fit validity and reliability criteria based on validator assessment and student responses. Many Facet Rasch Measurement was used to confirm validity and reliability from 4 different validators based on e-module development in phase 1 and phase 2 using 10-item criteria. A rating scale analysis was used to check validity and reliability according to 233 student responses and item category interactions. The e-module achieved fit validity and reliability. The e-module implementation showed students gave higher responses, 55% (agree) and 39% (strongly agree), if the e-module can help them with digital literacy for understanding hoax information. The bias interaction and the differential item functioning have been discussed in this study. The findings will provide initial knowledge in the development and implementation of e-modules for preventing hoaxes and will improve students' understanding of filtering information in the digital literacy curriculum.
A Quantitative Study on the Effectiveness of Open Educational Resources (OER) in Enhancing Creative Thinking Skills
Authors: Sedayu Agung , Herpratiwi Herpratiwi , Yuliyanti Dwi , Distrik I Wayan
Published: January 2024

This research aims to provide empirical evidence on the effectiveness of Open Educational Resources (OER) in facilitating transformative learning experiences that enhance students' creative thinking skills. A quantitative approach was employed for the study, wherein two groups, experimental and control, underwent pre-tests and post-tests to measure variables such as fluency, flexibility, elaboration, and evaluation of their creative thinking abilities. The study revealed significant differences between pre-test and post-test scores for both groups, particularly in the indicators of flexibility and evaluation. However, diverse outcomes were observed when examining n-gain scores across all indicators of creative thinking skills, suggesting that the effectiveness of OER in facilitating transformative learning varies depending on the specific creative thinking indicators measured. The research emphasizes that while OER can facilitate transformative learning processes, it may not yield uniform results across all dimensions of creative thinking. The obtained results indicate no significant difference in flexibility. Contradictory conditions can be observed in fluency, elaboration, and evaluation indicators, showing significant differences. Therefore, educators should adopt varied approaches when integrating OER into their curricula to maximize the potential benefits of enhancing students' creative thinking skills. For future research, it is highly recommended to focus on the effectiveness of OER based on the type of content or subject matter taught to identify the most effective sources. Further research is also needed to compare the effectiveness of OER with other teaching methods.
Análisis de características que influyen en la deserción estudiantil en el contexto de una universidad latinoamericana
Authors: Castro Rojas Luis Fernando , Espitia Peña Esperanza , Romero Cuero Edwin
Published: January 2024

El presente trabajo pretende profundizar en el estudio de la deserción estudiantil universitaria, un problema serio que preocupa a los gobiernos, las instituciones universitarias y estudiantes a nivel mundial. Para lograr lo anterior, este estudio aplica minería de datos con el propósito de analizar la deserción estudiantil en una universidad latinoamericana, basados en el descubrimiento de las características relevantes que tienen mayor incidencia y en la identificación de patrones que faciliten el entendimiento de dicho problema. La metodología empleada se basa en una adaptación de los pasos propuestos por KDD (descubrimiento de conocimiento en bases de datos) y en un diseño de investigación observacional, descriptivo y transversal, con muestreo por conveniencia. La muestra está compuesta por 10705 estudiantes, los cuales se encuentran distribuidos en 7 facultades y 33 programas académicos de pregrado. Las relaciones predictivas entre la condición de estudiante desertor y las características influyentes, se han sometido a verificación mediante un modelo basado en árbol de decisión. Como resultado de este trabajo, se identifican algunas técnicas y métodos comúnmente empleados para este tipo de estudios y se desarrolla un método para identificar patrones de relaciones entre las características más influyentes en el fenómeno de la deserción. Se encontró que las principales características influyentes en este tipo de deserción se refieren a estrato socioeconómico, género, situación laboral y promedio acumulado. Un aspecto a resaltar es la coincidencia de los hallazgos de este trabajo con los resultados de otros trabajos similares a nivel mundial, en los cuales se identificó el rendimiento académico como un factor fundamental que incide en la deserción universitaria. Se concluye que la deserción estudiantil universitaria no depende de una sola característica, sino que es causada por un conjunto de características y su interrelación.
Variación espacio-temporal de la calidad del agua del río AburráMedellín utilizando la conductividad eléctrica en el periodo 2010-2020. Parte 2
Authors: Giraldo Buitrago Lina Claudia , Gómez-Miranda I.N.
Published: January 2024

El deterioro del ambiente y en especial la crisis por la disponibilidad de agua, hallevado a que los países en vía de desarrollo avancen en la protección, evitandoel vertimiento de aguas residuales y en el seguimiento a la calidad. En la ciudadde Medellín, se propuso el uso de la conductividad eléctrica como un indicadorde calidad de agua en el río Aburrá-Medellín como una alternativa para explicary mantener informada a la comunidad acerca de cómo están las estacionesde monitoreo del río a través de colores y así continuar sensibilizando en laimportancia del cuidado del agua. Con el fin de estudiar las variaciones espacialesy temporales de la calidad del agua en el río a partir del indicador conductividadeléctrica, y considerando los datos categóricos que se obtienen con el indicador,se asignó un número de 1 a 5 (muy mala, mala, regular, aceptable y buena calidad,respectivamente). En este artículo utilizamos métodos estadísticos como latabulación cruzada para describir las relaciones entre las variables categóricasa través de conteos y análisis de correspondencia múltiple para representar lasasociaciones entre los factores que afectan la calidad del agua usando los mapas decorrespondencia. Se encontró que los caudales bajos corresponden a las condicionesde calidad más críticas, y aunque se observa un deterioro a medida que el río fluyeaguas abajo (entre las estaciones de monitoreo) la influencia de los niveles de agua esmayor. El análisis estadístico mostró una asociación relativamente alta del indicadorde calidad y los caudales, además, que la calidad del agua se deteriora en la tarde y enlos años finales de monitoreo en caudales bajos.
Optimización de la tardanza total en máquinas paralelas: caso de estudio en la industria del café
Authors: Uribe Alejandro , López Duque Santiago , Mesa López Juan Pablo , ¿Montoya Echeverry Jose Alejandro
Published: January 2024

La programación de producción es una de las tareas con mayor importancia en sistemas de manufactura ya que permite la asignación de trabajos con cierto número de recursos disponibles. En la industria de manufactura y de servicios, poder cumplir con los compromisos acordados con los diferentes clientes y con los plazos de producción puede generar mayores niveles de satisfacción y ventajas competitivas en el mercado. Por otra parte, una de las principales industrias a nivel mundial es la cafetera. El café es la segunda materia prima más negociada del mundo. Por lo tanto, en esta investigación se aborda la optimización de la tardanza total en la programación de trabajos en máquinas paralelas para un caso de estudio en una tostadora de café. Este es un problema NP-hard donde cada trabajo requiere del proceso de tostión y, además, cuenta con una fecha de entrega asociada. El tiempo de procesamiento de cada trabajo depende de la máquina que se designe y no todas las máquinas puede ejecutar todos los trabajos. Se presenta el modelo matemático para describir el problema mediante programación lineal entera mixta y se implementa en Python. Adicionalmente, se propone un modelo mate heurístico basado en la heurística ATC que permite reducir el tiempo de cómputo y obtener soluciones cercanas al óptimo. Este modelo fue evaluado con mil instancias de datos reales del proceso de tostión. Para la solución del problema se utilizó el optimizador Gurobi. El método exacto muestra altos tiempos de cómputo por lo que se propuso realizar primero la secuenciación de trabajos para luego asignarlos a las maquinas por medio de un modelo matemático simplificado. Al utilizar el modelo mate heurístico propuesto se logra reducir en promedio un 53.98% el tiempo de ejecución y con respecto a la tardanza de la solución, este modelo logra una mediana del 0.0% con respecto al óptimo.
Kindergarten Teachers’ Perceptions of Ecological Education Programs in Preschoolers – A Focus Group Approach
Authors:   Doctoral School ", Marin Andreea A. ,   Education, Reflection, Development",   , Faculty of Psychology and Educational Sciences, Babes-Bolyai University, 7 Sindicatelor Street, Cluj-Napoca, Romania., Rusu Alina S. ,   Faculty of Animal Science and Biotechnologies, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Calea Manastur Street, No. 3-5, Romania
Published: January 2024

The purpose of ecological education (EE), in addition to promoting understanding of environmental issues and the motivation to deal with them, is to ensure that preschoolers understand that humans are part of the biosphere and that they have the ability to impact its functionality in various levels. Kindergarten teachers are important agents of change in terms of creating opportunities for children to experience and internalise values based on ecological education. The objective of this study is to investigate teachers' perceptions of the EE programs in preschoolers, i.e. activities focusing on the direction of developing environmentally friendly behaviors and attitudes in children. Focus group methodological approach was used in order to collect the reflections of five kindergarten teachers in Romania. The focus group was guided by specific questions. Group members were convened online, being informed that the entire meeting would be recorded and that the data would be confidential and used strictly for research purposes Following the thematic qualitative analysis of the transcript, the idenitified themes indicate that teachers expressed openness and readiness to implement ecological educational activities in their own classes with the aim of fostering a friendly behavior of children with the environment.
Analisis Semiotika Roland Barthes pada Bukhur dalam Tradisi Islam
Authors: Nurul Shabah  , El Bilad Cecep Zakarias , Khair Muhammad Saiful
Published: January 2024

This article discusses bukhur is a small piece of aromatic wood or a mixture of traditional natural ingredients, with the main ingredient being wood (oudh) soaked in fragrant oil and blended with other natural materials. The purpose of this research is to understand bukhur in the Islamic tradition by identifying its denotation, connotation, and mythology found within the symbol of bukhur. This research method employs a qualitative descriptive research approach. The data analysis in this study utilizes Roland Barthes' semiotic analysis, which employs the signifier and signified system to explore denotation, connotation, and myths associated with bukhur. And this research result explains that by using semiotic analysis, it can be understood how signs and symbols in the incense burner play an important role in shaping religious identity.
Application of the Kuka Kube Test-Bed for the Hardware-in-the-Loop Validation of the Space Manipulator Control System
Authors: Wojtunik Mateusz , Łuczak Piotr , Rybus Tomasz , Granosik Grzegorz
Published: January 2024

The on-ground validation of control systems designed for manipulators working in orbit is very difficult due to the necessity of simulating the microgravity environment on Earth. In this paper, we present the possibilities of utilising the KUKA KUBE test-bed with industrial robots to experimentally verify space systems using hardware-in-the-loop tests. The fixed-base KUKA industrial robot is operated in gravitational environment, while the space system model plant is solved in real time parallel to on-ground experiment. The test-bed measurements are the input of the model plant, and the output of the model is treated as an input for the industrial robot actuation. In the performed experiment, the control system based on the Dynamic Jacobian is validated. The desired point that is reached by the manipulator's end-effector is constant in the simulated environment and moving with respect to the test-bed frame. The position of the space manipulator's end-effector is calculated by evaluating dynamics of the satellite in real-time model. The results show that the control system applied to the KUKA robot works correctly. The measurements from the torque sensors mounted in KUKA robot's joints are in accordance with the simulation results. This fact enhances the possibilities of gravity compensation, thus simulating microgravity environment on the test-bed.
Personzentrierte Gruppenpsychotherapie für Jugendliche mit Autismus-Spektrum-Störungen – das KOMPASS-Training
Authors: Jenny Bettina , Schär Camille
Published: January 2024

Im Zentrum für Kinder- und Jugendpsychiatrie der Universität Zürich wurde der Personzentrierte Ansatz konzeptuell auf Kinder-Gruppentherapien übertragen und bei verschiedenen Störungsbildern evaluiert. Da es zur konkreten gruppentherapeutischen Umsetzung für Jugendliche mit einer Autismus-Spektrum-Störung kaum Literatur gibt, entwickelten die Therapeuten1 im Rahmen einer intensiven Auseinandersetzung mit den spezifischen Besonderheiten dieser Jugendlichen ein eigenes Behandlungskonzept auf personzentrierter Grundlage, das Kompetenztraining in der Gruppe für Jugendliche mit Autismus-Spektrum-Störungen (KOMPASS). Die praktische Vorgehensweise wird beispielhaft an Hand der KOMPASS-Module ‚Emotionen‘ und ‚Small Talk‘ geschildert, in denen sich zwei therapeutische Vorgehensweisen darstellen lassen. Inzwischen wurden vier sogenannte Basis-Trainings, in denen 28 Mädchen und Jungen im Alter von 12 –18 Jahren mit Asperger-Syndrom oder Atypischem Autismus behandelt wurden, evaluiert und mit einer Kontroll-Wartegruppe (n = 19) verglichen. Die vorläufigen Ergebnisse mit zufriedenstellenden bis guten Effektstärken sprechen für die Wirksamkeit des Gruppentrainings. Eltern und Lehrpersonen geben einen signifikanten Abbau der autistischen Symptomatik und einen Zuwachs an sozialen Kompetenzen an.
Eltern und Kinder im Trennungsprozess – Personzentriertes Handeln in der familiengerichtlichen Begutachtung
Authors: Junker-Moch Manuela , Moch Matthias
Published: January 2024

Ehepartner mit Kindern, die in einer Trennungssituation leben, sich trennen wollen oder bereits geschieden oder getrennt sind, stehen vor der Frage, bei wem ihre Kinder zukünftig leben sollen. In Konfliktfällen entscheidet das Familiengericht über die Personensorge und das Aufenthaltsbestimmungsrecht, wobei das Gericht in hochstrittigen, schwierigen Problemlagen vor der Entscheidung oftmals eine gutachterliche Stellungnahme einholt. In diesem Fall sehen sich die Familien mit einer Gutachterin oder einem Gutachter konfrontiert, der/die aus fachlicher Sicht zu einer Regelung im Sinne des Kindeswohls Stellung beziehen soll. Ein personzentrierter Umgang mit den Betroffenen unterstützt deren Offenheit im Gespräch. Eine wertschätzende, akzeptierende und empathische Grundhaltung von Seiten des/der Sachverständigen allen Beteiligten gegenüber sowie Kongruenz im Gespräch mit Einzelnen oder gemeinsam sowie auch in der Exploration mit dem Kind regen zur Veränderung von Kommunikationsstrukturen in der Familie an. Dies unterstützt den Prozess der Begutachtung im Idealfall dahingehend, dass für die Familie akzeptable und langfristig tragende Empfehlungen erarbeitet werden können. In jedem Fall aber wird bei den Betroffenen der Prozess der Selbstexploration und der Symbolisierung angeregt.
La espera del evento: dimensiones de la (in)movilidad doméstica en La vida inmueble de Federico Galende y Preguntas frecuentes de Nona Fernández
Authors: Oliver María Paz
Published: January 2024

Set in the Covid-19 pandemic, La vida inmueble (2022) by Federico Galende and Preguntas frecuentes (2020) by Nona Fernández address the daily life of confinement as a tension between immobility and mobility. Both Chilean works propose in the act of waiting an opening towards change in relation to an event that questions the politics of the pandemic and the sense of community. In its affective dimension, the health crisis projects new alliances of life that transform the everyday landscape into an imaginary and virtual community. On the one hand, in La vida inmueble, immobility will be explored as a wait that produces an affective practice of the domestic space in dialogue with the public space. On the other, in the case of Fernández, the link between waiting and the critical potential of everyday life will be analyzed in relation to a landscape that connects the pandemic with the 2019 October protest.
SUITABILITY ANALYSIS OF TOBACCO CULTIVATION TECHNIQUE IN NAGARI BARUAH GUNUNG
Authors: Nursamsi Nursamsi , Syahfitra Muhammad
Published: January 2024

The problem with tobacco farmers in Nagari Baruah Gununang is a productivity. Tobacco productivity is below national productivity due to cultivation techniques that do not comply with standards. The research method uses suitability analysis to assess the level of suitability of cultivation techniques used by farmers in Nagari Baruah Gunuang. The level of suitability is analyzed using check sheet based on a likert scale by comparing farmers actual and standards cultivation. The research results show that suitability level of tobacco cultivation technique is 70%. This means that the cultivation techniques used by farmers are still classified as almost in accordance with standards. The stages of cultivation that do not meet standards are planting; fertilization; and weeding, watering and loosening. The problems that cause non-compliance with this standard are close spacing of plants, lack of use of manure and dolomite, inappropriate dosage and type of chemical fertilizer, and insufficient watering and irrigation.
Kurumsal Yönetim Olgunluk Düzeyi Performansının Çok Kriterli Karar Verme Yöntemleriyle Değerlendirilmesi
Authors: KILIÇARSLAN Abdullah
Published: January 2024

Borsa İstanbul’da kurumsal yönetim standart ve ilkelerinin şirketler bazında performans başarısı, Kurumsal Yönetim Olgunluk Düzeyi’nin ölçülebilirliğiyle ortaya konulmaktadır. Kurumsal yönetim ilke ve standartlarının uygulamaya konu olduğu piyasa ve sektörlerin spesifik özellikleri, kurumsal yönetimin başarısını etkileyen temel faktörler arasında sayılabilir. Dolayısıyla n farklı risk değişkeninin kurumsal yönetim üzerindeki etkisini ölçümlemek, çok kriterli bir karar problemidir. Bu çalışmada, Merkezi Kayıt Kuruluşu tarafından kamuoyuyla paylaşılan 2018-2022 dönemlerine ait Kurumsal Yönetim Olgunluk Düzeyi verileri kullanılmış olup, Çok Kriterli Karar Verme Yöntemleriyle şirket gruplarının Kurumsal Yönetim Olgunluk Düzeyi performansları analiz edilmiştir. Kriterlerin ağırlıklandırılmasında CRITIC yöntemi, alternatif sıralamalarında ise WASPAS, MARCOS ve COCOSO yöntemleri kullanılmıştır. Yöntemlerin sıralama sonuçları arasındaki ilişkiler, Spearman korelasyon yöntemi kullanılarak belirlenmiştir. WASPAS ve MARCOS yöntem sıralama sonuçları arasındaki korelasyon düzeyinin yüksek olduğu tespit edilmiştir. WASPAS, MARCOS ve COCOSO yöntemleriyle elde edilen sıralama sonuçlarının, genel olarak Merkezi Kayıt Kuruluşu tarafından hesaplanan genel başarı puan ve sıralamaları ile farklılaştığı görülmüştür.
Salivary Antioxidants Role in Oral Health and Diseases (A Review Article)
Authors: Abadul Gabar Al-Halfi Hanadi , Sh. Al-Essa Hussein , G. Fadil Adil
Published: January 2024

Background: Saliva is the first defense system of the body through its antioxidant status (total antioxidant capacity), which is either enzymatic or non-enzymatic antioxidants, which block the process of oxidation by neutralizing free radicals; therefore, the objective of this review is to evaluate the role of salivary antioxidant biomarkers in the diagnosis and monitoring of many oral and periodontal diseases and related systemic disorders. Method: We searched for articles published on PubMed and Google Scholar in the last 20 years and then filtered the mints 60 papers according to the following keywords: saliva, total antioxidant capacity (TAC) and oxidative stress (OS). Conclusion: Saliva samples can be beneficial in demonstrating oxidant-antioxidant balance in oral and systemic illnesses and may be a suitable sample type in the diagnosis and monitoring of many pathologies in the body.
Characteristic Abnormalities in Saliva Biochemistry in Patients with COVID-19: A Systematic Review and Meta-Analysis
Authors: R. Sarhat Entedhar , A. Wadi Siham , A. Jaba Ruqaya , Y. Khalaf Hussam , Rifaat Sarhat Thuraia
Published: January 2024

Background: Outbreak pneumonia announced in Wuhan, China, in December 2019, had its causative factor classified as a new coronavirus (SARS-CoV-2). Since saliva can host several viruses including SARS-CoV-2, the transmission chance of viruses through saliva, particularly those causing respiratory infections, is unavoidable. COVID-19 can be detected through salivary diagnostic testing which has lots of advantages for medical care professionals and patients. However, the utility of saliva in diagnosing COVID-19 infection remains understudied. Aim of the study: In this review, we attempt to provide a comprehensive and updated source of information about salivary markers of liver enzyme, cytokines and oxidative stress in associated with the infections caused by COVID-19 and the various effects it has had on the dental profession and patients visits to dental clinics. Methods: A systematic search was conducted in PubMed/Medline, EMBASE, and Google Scholar, Scopus, and Web of Science, and Google Scholar from December 1, 2020, till April 15, 2021. Results: Nine studies were included in this study. Pooled results showed a significant increase in salivary liver enzymes (ALT, AST, ALP, GGT among patients with Covid‐19. Three studies showed a significant elevations in salivary TNF-α, CRP, IL‐6 and,IL-10 levels among patients with Covid‐19. Four studies that reported a significant in elevation salivary level of MDA, whereas reduction salivary levels of SOD, catalase, GPX. Conclusion: Our meta-analysis shows that deranged of salivary liver enzymes , hyper-inflammation, may indicate severe COVID-19 and could also predict mortality. Larger studies are needed to evaluate the relationship between derangement in salivary biochemical and mortality in COVID-19.
Teeth Bracket Adhesives: Clinical Considerations: A Review Article
Authors: Sobhi Salih Al Qassar Sarmad , Rafea Yahya Al-Mallah Mahmood , Khalid Ahmed Mahmood
Published: January 2024

At the beginning of orthodontic practice, with fixed appliances, the multi-banding technique of the teeth was used, which had aesthetic disadvantages and often provoked aggression to the gingival tissues. To overcome these unfavorable characteristics, developing the technique of direct bonding of brackets brings the advantages of reducing the cost and time during the treatment and make easier cleaning. The advent of using acid etching in a dental practice which was introduced by Buonocore (Error! Reference source not found.) in 1955, enabling bonding between bracket base and enamel of the teeth. This adhesion had a high impact on esthetic and conservative orthodontics. The advantages of such a direct bonding technique to the tooth surface are reduced the cost and time of overall orthodontic treatment. Additionally, it makes the oral hygiene for the patients more simple and easy. The aims of this paper is to conduct a review of formerly published articles that are dealing with the orthodontic bonding to teeth enamel. It was confirmed that composites resin (CR) beside glass ionomer cement (GIC) are suitable material for such bonding. This could be because of its GIC biocompatibility, fluoride-releasing capacity, as well as lack of acid etching on the tooth surface. In another hand, resin-modified glass ionomer (RMGI) has grown in acceptance among orthodontists. Light polymerized orthodontic adhesives, on the other hand, remain the best adhesives for bracket bonding due to their esthetic and mechanical features, and their use is widespread (Error! Reference source not found., Error! Reference source not found.). In 1958, Sadler (2) recorded the first attempt at direct bonding of orthodontic accessories to the tooth surface. Since the 1960s, studies have been made for improving the procedure in such a way that success in this practice is guaranteed and the use of metallic brackets, directly bonded to enamel. The introduction of acid etching that was presented by Buonocore (Error! Reference source not found.) in 1955 carried out the opportunity of bonding the base of the bracket with the enamel surfaces and create mechanical retentions in the teeth. Thus, from the 1970s onwards, composite
The discourse of right-wing radicals in online communities (using the example of the VK social network)
Authors: Shchekotin Evgenii Viktorovich
Published: January 2024

The object of the study are discourses that are broadcast by supporters of right-wing radical ideology in the relevant communities in the largest Russian social network VKontakte. The study of the discourse of right-wing radicals is an urgent topic of scientific and practical research in modern socio-political conditions. The study of the discourses of right-wing radicals helps to better understand the value-ideological attitudes of representatives of this group of political extremists and to reveal the rhetorical techniques and practices that they exploit in the process of mobilizing supporters. The analysis of the discourses of right-wing radicals in social media is especially relevant, since in the conditions of a digital society, the Internet is becoming the leading source of information for a significant part of the population. Four thematic types of discourses are identified – racist, anti-Soviet, anti-Semitic and social-populist discourses. Racist discourse is characteristic of the communities of the "new" and "alternative" right, while supporters of the "old", imperial right actively exploit the theme of anti-Soviet discourse. Anti-Semitic and social-populist discourses are rather poorly represented in the communities selected for the study. With the help of PolyAnalist software, six clusters of terms have been identified based on the occurrence in texts in right-wing radical communities: news, value, anti-migrant, historical, socio-economic. The analysis of the frequency of mentioning words in negative tonality and positive tonality in the posts of right-wing communities is carried out. There are two major objects to which the negative discourse is directed: the modern political regime in the Russian Federation and the Soviet period.
Short-Term Collision Probability Caused by Debris Cloud
Authors: Parigini Cristina , Algethamie Reem , Armellin Roberto
Published: January 2024

We propose a method for a fast and accurate estimation of the collision probability in a short window following the generation of a debris cloud. A multirevolution Lambert targeting problem is employed to determine all the locations where the collision probability is nonnegligible. Then, the Lambert problem and state transition matrix are used to obtain the image of the target body in the spread velocity space, where the collision probability computation is performed. To perform and control the accuracy of the integration of the collision rate needed to obtain collision probabilities, we apply high-order Taylor expansion and automatic domain splitting techniques. The method is validated using a Monte Carlo simulation and a literature-based test case. Test cases demonstrate the validity of the approach for Keplerian and perturbed dynamics.
Cognitive and emotional development of first-graders in the Sakha Republic (Yakutia)
Authors: Ivanova M. K.
Published: January 2024

The relevance of the problem of adaptation of first-graders to school has become increasingly obvious due to the increase in neuropsychiatric diseases of children, as well as violations of academic performance, behavior and interpersonal relationships among children of primary school age. The practice shows that untimely recognition of these problems and the lack of special corrective programs have lead not only to chronic retardation, but also to secondary disorders of the child’s psychosocial development, and to various forms of deviant behavior. Purpose of the study: to analyze the cognitive and emotional development of first-graders. Research objectives: determining the research program; diagnostics of cognitive abilities and emotional sphere of children; analysis of research results. As part of the study, such methods as subtests of diagnostic complexes aimed at assessing regulatory functions were used: the Memory for Designs technique, the Sentence Repetition technique, the Sorting cards by variable attribute technique Dimensional Change Card Sorting, Inhibition technique, and the tests aimed at studying the ability to understand emotions [1]. The levels of cognitive and emotional development of first-graders, participants in a longitudinal study of the project “Growing with Yakutia” were studied, information about their academic performance and social success was collected.
Ethical, aesthetic, socio-political background and aspects of Kant’s philosophy
Authors: Kozhevnikov N. N. , Danilova V. S.
Published: January 2024

The ethical and aesthetic aspects of Kant’s philosophy had a huge impact on the socio-cultural circles of writers and artists, and turned out to be more accessible both to philosophers and to all fans of philosophy. Social and political issues have always worried people more than theoretical aspects. Kant raises the question of eternal peace, refutes the existing evidence of God, explores the origin of the moral law, its ontological basis and offers its solution. It was an era of social and scientific revolutions: the social one broke the structures of feudalism, opening new horizons for cultural and political transformations; the scientific one made a paradigm shift. The methodological revolution of Bacon and Descartes led to the emergence of fundamentally new approaches, for example, induction. The Galileo-Newton scientific revolution shaped a new universalism. Kant’s philosophy organically complemented all these processes. His postulates of practical reason embody transcendental ideas in objective reality, which the will helps to find corresponding objects. The revolutionary impact exerted by the Critique of Practical Reason, according to Kant’s followers, was much stronger than the ideas of the Great French Revolution. Kant explored the aesthetic ability of man in the Critique of Judgment, considering it as the ability of the soul to unite the faculties of knowledge and desire.
Application of project technology in teaching Russian as a foreign language: the case of topic «Day of the Sakha Republic (Yakutia)»
Authors: Dishkant E. V.
Published: January 2024

The article describes the practical application of the project method in teaching Russian as a foreign language, which allows to activate the educational and cognitive activity of students, to develop their communication and teamwork skills. The author considers the organization of project technology when studying the course of «Country Studies» in a group of Chinese bachelors, namely the topic «The Sakha Republic (Yakutia)». At the pre-text stage, lexical work is carried out with new words, the translation into Chinese of words that are not included in the lexical minimum of students of the basic level of proficiency in Russian is proposed. An educational text about the Sakha Republic (Yakutia) with emphasis was developed. At the post-text stage, work is carried out on questions on comprehending what has been read and performing grammatical tasks on the use and formation of full forms of participles and declension of quantitative and ordinal numerals. The creative projects developed by students on the topic «Sights of the city of Yakutsk», including an illustrated Russian-Chinese terminological dictionary, information about cultural objects, student reviews, are presented. The final creative task was the implementation of the case – the creation of a mock-up of a holiday card for the Day of the Sakha Republic (Yakutia). Presenting their work, students developed the skills of oral monological coherent speech. To sum up, the author comes to the conclusion about the expediency and effectiveness of the implementation of the project methodology in teaching Russian as a foreign language, contributing to the creative activity of students and improving their communication skills.
A bal kamrai kontraktilitás korszerű echokardiográfiás vizsgálata: a miokardiális munka
Authors: Ladányi Zsuzsanna , Fábián Alexandra , Ujvári Adrienn , Tokodi Márton , Turschl Tímea , Bálint Tímea , Nagy Dávid , Ruppert Mihály , Kovács Attila , Merkely Béla , Lakatos Bálint Károly
Published: January 2024

A bal kamrai szisztolés funkció legalapvetőbb echokardiográfi ás paramétere az ejekciós frakció (EF), azonban ennek értéke nem mindig követi a kontraktilitás változásait, mivel a myocardium aktuális állapotán túl az elő- és utóterhelési viszonyok is jelentősen befolyásolják. Az elmúlt évtizedben népszerűvé vált, speckle-tracking analízissel meghatározható globális longitudinális strain (GLS). Bár jóval korábban, akár szubklinikus stádiumban is képes a myocardium betegségét kimutatni, azonban ezt a paramétert is jelentősen befolyásolja mind a volumen-, mind a nyomásterhelés. Ezen limitációk kiküszöbölésére került bevezetésre a nyomás-strain hurok elemzésével meghatározható miokardiális munka, amely potenciális szerepét már számos kórállapotban vizsgálták, ahol diagnosztikus és prognosztikus értéke a GLS-ét is meghaladta. Ez az új módszer a miokardiális deformációt a pillanatnyi bal kamrai nyomás függvényében vizsgálja. Így feltételezhető, hogy a nyomásterheléssel járó kórállapotokban is megbízható paramétere a bal kamra kontraktilitásának, és ezen tulajdonsága miatt értékes diagnosztikus és prognosztikus marker. Összefoglaló cikkünk célja annak bemutatása, hogy a miokardiális munka paraméterek milyen hozzáadott értékkel rendelkeznek különböző kardiovaszkuláris kórállapotokban.
A multimodális képalkotás szerepe új típusú felnőtt kongenitális intervenciók tervezésében – SVASD, TricValve, VenusP-valve
Authors: Pataki Szabina , Vértesaljai Márton , Ablonczy László , Környei László , Fontos Géza , Andréka Péter , Bálint Olga Hajnalka
Published: January 2024

A veleszületett szívbetegségek heterogén betegcsoportot képeznek a kardiológiai betegellátásban, a háttérben álló anatómiai okok széles spektruma, a korábbi műtétek, intervenciók változatossága, a reziduális eltérések sokszínűsége, javuló túlélési adatok mellett, egyúttal újabb kihívásokat is jelentenek gondozásuk során. A kongenitális betegcsoportban a hosszú távú utánkövetés során, a reziduális eltérések felismerésében, nyomonkövetésében, az újfajta katéterintervenciós eszközökkel való megoldás kivitelezhetőségének megítélésében egyre inkább az az irányvonal érvényesül, hogy a különböző képalkotó eszközök együttes alkalmazása szükséges az információk beszerzéséhez, hiszen minden beteg egyedi mérlegelést igényel, sok esetben az anatómia komplexitása nélkülözhetetlenné teszi a multimodális megközelítést. A többféle képalkotó módszer más-más aspektusból vizsgálja az eltéréseket, és jól kiegészítik egymást. Szív-MR-vizsgálattal precízebb intervencióindikációt tudunk felállítani (jobbkamra-volumen, illetve -funkció, aorta- vagy pulmonalis billentyűregurgitáció foka, söntvolumenek stb.), a CT-angiográfi a pontosabb intervenciós tervezést, eszközkiválasztást tesz lehetővé, tekintettel a jobb felbontásra a kiáramlási pályák, valamint az extrakardiális anatómiai viszonyok feltérképezésében. Jelen értekezés célja a felnőtt kongenitális betegek körében, az utóbbi években elérhetővé vált katéterintervenciók közül három beavatkozás bemutatása a képalkotó vizsgálatok tükrében, amely kiválóan szemlélteti a multimodális képalkotás szükségességét ezen beavatkozások során.
Decoding the Molecular Dance: In Silico Exploration of Cannabinoid Interactions with Key Protein Targets for Therapeutic Insights
Authors: Docampo-Palcios Maite , Ramirez Giovanni , Tesfatsion Tesfay , Pittiglio Monica , Ray Kyle , Cruces Westley
Published: January 2024

As hemp-based cannabinoids are continuously gaining popularity, synthesis and extraction methods for these compounds are ever-changing. Within the cannabinoid market, hydrogenated derivatives are also gaining popularity at an accelerated rate, with the need for in-depth analysis of these compounds pertinent to increasing the knowledge of cannabis chemistry. Our lab used Schrödinger to dock natural and synthetic cannabinoids in various CB1 and CB2 receptors, PPAR-γ, PAK1, and GPR119 complex including several enzymes, to evaluate the interacting residues within the known binding pockets, comprising the computation of binding energies, predicting ADME characteristics, and evaluating P450 sites of metabolism. The purpose of identifying active residues, sites of metabolism, and ADME characteristics for 40 various cannabinoids is to provide guidance in computer-aided drug design and rationalization in designing and synthesis of analogs.
Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine
Authors: Forbes Thomas P , Gillen John Greg , Feeney William , Ho Johnny
Published: January 2024

Distributed and point-of-care (POC) manufacturing facilities enable an agile pharmaceutical production paradigm that can respond to localized needs, providing personalized and precision medicine. These capabilities are critical for narrow therapeutic index drugs and pediatric or geriatric dosing, among other specialized needs. Advanced additive manufacturing, 3D printing, and drop-on-demand (DoD) dispensing technologies have begun expanding into pharmaceutical production. We employed a quality by design (QbD) framework to identify critical quality attributes (CQAs), critical material attributes (CMAs), and critical process parameters (CPPs) of a pharmaceutical manufacturing framework that encompasses the production of active pharmaceutical ingredient (API) ‘inks’ at a centralized facility, which are distributed to POC sites for DoD dispensing into/onto delivery vehicles (e.g., orodispersible films, capsules, single liquid dose vials). QbD considerations and cause-and-effect analyses identified the dispensed API quantity and solid state form (CQAs), as well as nozzle diameter, system pressure channel, and number of drops dispensed (CPPs) for detailed investigation. Final assay quantification and content uniformity CQAs were measured from demonstrative levothyroxine sodium single-dose liquid vials of glycerin/water, meeting standard acceptance values. Each POC facility is unlikely to maintain full quality control laboratory capabilities, requiring development of appropriate atline or inline methods to ensure quality control. We developed control strategies, including, atline UV-Vis verification of the API ink prior to dispensing, inline drop counting during dispensing, intermediate atline dispensed volume checks, and offline batch confirmation by LC-MS/MS following production.
Gold-catalysed Heck Reactions: Fact or Fiction?
Authors: Budzelaar Peter H. M. , Bochmann Manfred , Landrini Martina , Rocchigiani Luca
Published: January 2024

Two recent high-profile publications reported the formation of Heck-type arylated alkenes catalysed by MeDalPhosAuCl / AgOTf (J. Am. Chem. Soc. 2023, 145, 8810) and their cyclisation to tetralines (Angew. Chem. Int. Ed. 2023, e202312786). It was claimed that these were the first demonstrations in gold catalysis of alkene insertion into Au-aryl bonds, β-H elimination and chain-walking by Au-H cations. We show here that in fact this chemistry is a two-stage process. Only the first step, the production of an alkyl triflate ester as the primary organic product by the well-known alkene heteroarylation sequence, involves gold. The subsequent formation of Heck-type olefins and their cyclisation to tetralines represent classical H+-triggered carbocationic chemistry. These steps proceed in the absence of gold with identical results. Literature claims of new gold reactivity such as chain walking by the putative [LAuH]2+ dication have no basis in fact.
A review of mathematical modeling of bone remodeling from a systems biology perspective
Authors: Cook Carley V. , Lighty Ariel M. , Smith Brenda J. , Ford Versypt Ashlee N.
Published: January 2024

Bone remodeling is an essential physiological process in the adult skeleton. Due to the complex nature of this process, many mathematical models of bone remodeling have been developed. Each of these models has unique features, but they have underlying patterns. In this review, the authors highlight the important aspects frequently found in mathematical models for bone remodeling and discuss how and why these aspects are included when considering the physiology of the bone basic multicellular unit, which is the term used for the collection of cells responsible for bone remodeling. The review also emphasizes the view of bone remodeling from a systems biology perspective. Understanding the systemic mechanisms involved in remodeling will help provide information on bone pathology associated with aging, endocrine disorders, cancers, and inflammatory conditions and enhance systems pharmacology. Furthermore, some features of the bone remodeling cycle and interactions with other organ systems that have not yet been modeled mathematically are discussed as promising future directions in the field.
Synthesis and Characterization of Cu-containing Chiral Metal Halides and Role of Halogenation of the Organic Ligand
Authors: Malavasi Lorenzo , Dibenedetto Andrea , Coccia Clarissa , Boiocchi Massimo , Moroni Marco , Milanese Chiara
Published: January 2024

We report herein novel chiral copper metal chlorides, namely (R/S-ClMBA)2CuCl4 (ClMBA = 4-(chloromethyl)benzylammonium), together with the corresponding racemic compound. The two chiral samples are composed of isolated CuCl4 tetrahedra and crystallize in the non-centrosymmetric C2 space group and present a significant absorption in the visible region of the spectrum with band gap around 2.50 eV. The racemic compound, on the other hand, gives origin to a different structural topology characterized by the presence of a quite unusual five coordination for Cu(II), with Cu2Cl6- dimers forming infinite chains along the b axis and presents, in addition, a strong reduction of band gap (around 1.76 eV). The two chiral samples display a circular dichroism response with anisotropy factors values around 0.02. The actual novel samples are investigated in comparison to the MBA-based (MBA=methylbenzylammonium) system in order to unveil the role of benzene ring halogenation on the structural and chiroptical properties indicating that the presence of chlorine leads to a doubling of the anisotropy factor.
Photochemical Dearomative Skeletal Modifications of Heteroaromatics
Authors: Ji Peng , Duan Kuaikuai , Li Menglong , Wang Zhiyuan , Zhang Yueteng , Wang Wei
Published: January 2024

Dearomatization has emerged as a powerful strategy for rapid construction of 3D molecular architectures from simple, abundant, and planar (hetero)arenes. With the renaissance of skeletal editing and photocatalysis, the photochemical dearomative skeletal modifications of heteroarenes, enabling facile access to pharmaceutically related saturated/semi-saturated heterocycles, finds its increasing applications in synthesis of nature products and drug-like molecules. Recently, plenty of novel photochemical mechanisms or strategies were reported to modify or edit the scaffolds of heteroaromatics through disturbing aromaticity. Herein, we provide a conceptually distinct overview on these innovations based on the degree of skeletal alternation through photochemical dearomatization strategies and highlight the synthetic application in medicinal chemistry.
Formation of the Ureido Bond in Anabaenopeptins by ApnA from Planktothrix agardhii CYA 126/8.
Authors: Philmus Benjamin , Hemscheidt Thomas
Published: January 2024

The process leading to the formation of the ureido bond linking lysine and tyrosine/arginine, respectively, in the anabaenopeptins has been reconstituted in vitro. Trapping experiments suggest that an enzyme bound lysine -carbamic acid is an intermediate. Labeling experiments with 18O-bicarbonate suggest that a carbamic acid mixed anhydride is formed from the tyrosine/arginine thioester and subsequently rearranged to yield the ureido-dipeptide.