bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes of Hepatic Metastasectomy for Colorectal Cancer Metastases in the Philippine General Hospital
Authors: Abon Juan Carlos , De Vera Ramon , Berberabe A’Ericson , Lopez Marc Paul
Published: November 2023

Rationale: The liver is the most common site of metastasis from colorectal cancer. Curative intent liver metastasectomy has shown improvement in overall survival. This manuscript will present the long-term oncologic outcomes of hepatic metastasectomy for colorectal cancer with resectable liver metastasis. Methods: Data of patients with resectable liver metastases from colorectal cancer who underwent hepatic resection at the Philippine General Hospital over a 10-year period was reviewed. The primary outcome investigated was overall survival. Results: Thirty patients were included in the study. The median overall survival was 20 months, with a 2-year and 5-year overall survival rate of 40% and 6.67% respectively. Eleven (36.67%) patients had disease recurrence, with a median disease-free survival of 16 months. A significant difference in survival was seen between patients with synchronous and metachronous liver metastasis (20.38 and 36.78 months respectively, p=0.0393) and in patients given adjuvant chemotherapy at any time in relation to the occurrence of the liver metastases versus patients who did not receive any adjuvant treatment (34.08 and 18.59 months respectively, p=0.0349). Trends towards improved overall survival were seen in patients 50 years old or less (36.86 versus 21.78 months, p=0.0837) and in patients with a clinical risk score of 2 or less (29.65 versus 19.62 months, p=0.1823), which may show significance in a higher-powered study. Conclusion: Improved overall survival was observed among patients with colorectal liver metastases undergoing hepatic metastasectomy compared to no liver resection. Conclusion: Improved overall survival was observed among patients with colorectal liver metastases undergoing hepatic metastasectomy compared to no liver resection. Key words: colorectal cancer, liver metastasis, metastasectomy, Philippines
PENYULUHAN PENGENALAN KONSELING KRISIS OLEH ORANGTUA BAGI PEMBENTUKAN PSIKOLOGI REMAJA
Authors: Siringo-ringo Marito , Zai Lertin , Lidia Kando  , Hutagalung Rona Sulastri
Published: November 2023

Crisis counseling takes place in an atmosphere of direct face-to-face communication or communication between the counselor and the adolescent which discusses various problems in individual counseling that is holistic and in-depth and touches on important things about the teenager, but is also specific towards problem solving. Through individual counseling, adolescents will understand their own condition, their environment, the problems they are experiencing, their strengths and weaknesses, and the possibility of efforts to overcome their problems. Counseling is one of the guidance techniques. Through this method efforts to provide assistance are given individually and directly face to face (communicating) between the counselor (counselor) and the client. In other words, the provision of assistance is carried out through a face-to-face relationship (four-eye relationship), which is carried out by interviewing the counselor (counselor) with the client. The problems that are solved through counseling techniques, are problems that are personal. The method used is lectures and discussions on the introduction of crisis counseling by parents for the formation of adolescent psychology. All stages have been carried out properly supported by the high participation of parents and youth.
PERANAN KUALITAS SPRITUAL ORANGTUA DALAM MENGEDUKASI PSIKOLOGIS KORBAN KEKERASAN PADA ANAK GEREJA BETHEL INDONESIA TAMAN LAGUNA INDAH
Authors: Suhartono Tony , Suryady Robertus , Suriana Suriana , Sinaga Agustutina , Abton Wara Yakobus Fernando
Published: November 2023

The quality of spirituality is when knowledge is the same as attitude and behavior. Broken personality is when knowledge is the same as attitude but not the same as behavior or knowledge is not the same as attitude, not the same as behavior. Caring for children is a heavy responsibility, because children will create a generation that will continue the dreams of their parents that have not been achieved. Good parents should maintain a harmonious relationship between family members. Harmonious relationships, full of attention, understanding and compassion will result in good behavior in children. Conversely, disharmony such as parental violence will affect the development of the child's soul that is not good, such as stubbornness, liars, and impolite. The child will depend on the first and foremost environment, namely his family, his father and mother who will determine him. Likewise regarding the diversity of children including in it, will be the responsibility of the parents. Parents have full responsibility for the growth and development of their children when they grow up to become knowledgeable and faithful people. The method used is lectures and discussion of the role of parents' spiritual qualities in educating the psychology of victims of child abuse. All stages have been carried out properly as evidenced by the great support the congregation has taken part in discussing this issue.
EFEKTIVITAS MODEL PEMBELAJARAN KONTEKSTUAL DAN PENERAPANNYA DALAM PEMBINAAN WARGA GEREJA
Authors: Pane Pranada
Published: November 2023

The formation of Church members is a very important task and must be carried out by the church for its members. Likewise, the formation of church members is a form of the church's responsibility to the Lord Jesus Christ who is the head of the church and also to others who in its understanding are to the congregation. Coaching is carried out with the aim of exploring and developing all the potential within the congregation and ultimately being applied in the ministry and dedicated to the interests of the Kingdom of God. As for the background of this writing, the author finds a church that is unconscious and also without adequate provisions to carry out the formation of church members even though it must be realized that coaching is something that is necessary and must be done so that the needs of the congregation are met, especially in spirituality. the congregation. To get information about the formation of the congregation, the author uses questions that the author conveys to the church members to ensure that the congregation receives guidance or not and if the congregation receives guidance to what extent and how the implementation of the coaching is carried out, because if the church can carry out coaching well for its citizens, the congregation will will experience increased knowledge of God's word and experience changes in life, especially growth in spirituality. In this paper, the author presents the Contextual Learning model for discussion at the next stage. The learning model is a learning model in formal schools but it is very strategic to be applied in building church members. One form of the learning process of this model can use facilities that directly involve the congregation itself and also facilities around the congregation including other fellow congregations, therefore by using the facilities and infrastructure that are around it, coaching can be more easily carried out effectively. and easier to understand, especially to be practiced by church members or the congregation it self.
CARA SISWA KRISTEN MENGATASI PENINGKATAN STRES PADA MASA PANDEMI
Authors: Suriyanti Intan
Published: November 2023

This Article provides an overview of how to overcome the increased stress that occurs in students during a pandemic. This stress occurs due to new habits and new way of learning methods caused by current global conditions due to many restriction. As a person who has Christian faith, Christian students are expected to be able to overcome the stresses of life they experience by approaching God with gratitude for all the goodness of the Lord Jesus Christ. So that in any situation, a student as the nation's next generation and is learning various things in this life will actually progress and develop. By communicating with Allah through worship, students are expected to have the right relationship and it is not just a religious ritual, but also a lifestyle that colors hearts, thoughts, words and behavior. So that any condition that will happen in the future, even though under conditions of limitations each student can study hard and diligently even the pressure can strengthen his faith, so that Christian students can come out as winners in facing this pandemic.
SEJARAH DAN PROFIL GEREJA KELUARGA TABGHA ALMA JAYA MALAYSIA
Authors: Pasaribu George Rudi Hartono , Steven  , Suryadi Robertus
Published: November 2023

This study aims to describe the history and profile of the Tabgha Family Church Alma Jaya in Malaysia, the background before starting church planting in Malaysia, building partnerships with local churches until the formation of the Tabgha Family Church Alma Jaya. The method used in this study is a qualitative approach, using the snowball technique with heuristic steps through observation, interviews, study of documents and determination of informants, data analysis, field observations, interviews with witnesses and historical actors, and focus group discussions. Data analysis by interpreting documents and information obtained in the field. Interpretation and discussion in the form of a description. The results of the data analysis show that the early entry of the Tabgha Family Church was born from a vision received by Pdt. Hanny Andries during a prayer and fasting movement for two years, from 1998 to 2000, the entry and development of the Tabgha Alma Jaya Family Church applied the model of cooperation with the local church with the characteristic of building friendship. The pattern of approach that stands out in outreach is to make the congregation feel at home and part of the family. The characteristics of the ministry of the Tabgha Alma Jaya Family Church are Prayer Strengthening, Worship Praise and the development of cell groups and the empowerment of the lay congregation.
PENGARUH PEMURIDAN REMAJA USIA 13-18 TAHUN TERHADAP PERTUMBUHAN JUMLAH KEHADIRAN REMAJA DI IBADAH JUNIOR CHURCH DI GBI TABGHA BATAM
Authors: Djaafar Andre , Purba Gomgom , Suhendra  , Cresty Agustina
Published: November 2023

Discipleship teenager’s is very essential for the growth of teenager’s attendance which does not affect the spiritual life but also outwardly, the phenomenon of declining discipleship is feared to also have a negative impact on the growth of teenager’s attendance in worship. This study aims to determine how much influence discipleship teenager’s directly have on the growth of church attendance. This study uses quantitative methods based on quantification in data collection and analysis to test the established hypotheses. Conducted at the Junior Church of Bethel Church Indonesia Tabgha Batam, from October 2021 to May 2022. The results of the research prove that the level of (1) understanding of the benefits of discipleship is in the range 176.80-185.375: moderate to high class, (2) the growth rate of attendance is in the range of 144.68-151.36: high class. This study also found (3) The contribution of the influence of discipleship partially to the growth of church attendance was 76.9%. The magnitude of the direct influence of the Discipleship teenager’s aged thirteen to eighteen year’s variable on the growth of church attendance is 24,066, meaning that if the Discipleship teenager’s (X) is 0, then the growth of church attendance (Y) Junior Church of Bethel Church Indonesia Tabgha Batam the value is 24,066 units. The regression coefficient of the Discipleship teenager’s variable (X) is 0.685; This means that if the Discipleship teenager’s is increased by one time, it will increase the growth of church attendance (Y) by 0.685.
PELAKSANAAN PENDIDIKAN AGAMA KRISTEN GEREJA DAN KELUARGA UNTUK MEMBANGUN IMAN REMAJA GBI BATU AJI
Authors: Suhartono Tony
Published: November 2023

This research is based on advances in digital-based technology that cause teenagers to experience a decline in faith in God. Most churches are more busy looking for souls to continue to grow than they are with youth's faith growth. Families are preoccupied with earning a living for the sake of the economy rather than developing the faith of teenagers. In connection with the problems above, the writer formulates the problems as follows: First, whether and how to build the faith of today's Christian youth through the church and family. Second, what is being done in carrying out Christian Religious Education at the Indonesian Bethel Church in the Batu Aji area to build the faith of today's youth. Third, do the Christian families at the Indonesian Bethel Church in the Batu Aji area carry out Christian Religious Education in building the faith of youth. After the research data were collected, the authors processed and analyzed to find out how the implementation of Christian religious education in the church and how the implementation of Christian education in the family in building youth faith. To find answers, the authors adjust the field observation data with the literature review data discussed in chapter two, with a simple descriptive analysis, the authors try to find things that are important in the implementation of church and family Christian religious education to build faith for youth. After everything is analyzed, the author finally concludes that the implementation of Christian religious education for churches and families to build youth faith is not optima.
PENGARUH KHOTBAH ALKITABIAH DARI PENGKHOTBAH TERHADAP INTENSITAS BERIBADAH
Authors: Suryadi Robertus
Published: November 2023

The main points relating to the preacher and the intensity of worship examined in this article include the personality and exemplary attitude of the preacher, mastery of the sermon material, interpretation of the sermon and discussion, the application of the text in the sermon in line with the context of the text and relevant to current life and appropriate use , the truth of the word delivered motivates the congregation towards the intensity of the church moved by the truth of the word delivered. The next explanation in this article is a description of the thoughts of church leaders about the importance of preaching the word and worship of Christianity. In accordance with the existing problems, the purpose of writing this scientific work is: First, to analyze and interpret the preacher for the preaching of the word. Second, to discuss how the personality of the preacher influences the content of sermons worshiped in the lives of believers today. In writing this scientific paper, the writer uses quantitative research methods.
ETIKA BERAPOLOGIA DI MEDIA SOSIAL
Authors: Simanjuntak Herbin , Mendrofa Feri Aman
Published: November 2023

Tulisan ini berusaha membawa pembaca untuk tidak memisahkan etika pada pelaksanaan apologia di media sosial. Beberapa dialog apologia yang ditampilkan sedikit banyak sering terseret keluar dari etika Kristen yang seharusnya tetap dipraktikan dalam keadaan apapun. Dampaknya kegiatan apologia tidak lagi menjadi berkat bahkan dapat berujung pada kosekuensi hukum. Melalui penelitian ini penulis menginginkan para praktisi pembela iman kristen tidak memisahkan etika menurut persepektif kristen dalam berapologia. Penyusunan tulisan ini memakai metode penelitian kualitatif dimana penulis mendasarkan penulisan penelitian ini pada fenomena yang penulis amati dari media sosial. Pengumpulan data dilakukan penulis melalui observasi lapangan yang bersumber dari tulisan dan video apologis yang telah dipublikasikan di platform media sosial dan meneliti berbagai kajian teori dari penelitian terdahulu yaitu melalui jurnal penelitian ilmiah dan buku buku terkait variabel penelitian. Dari tulisan ini didapatkan besarnya peluang berapologia di media sosial semakin meningkat dan semakin dibutuhkan etika kristen dalam mengkomunikasikan doktrin kristen di media sosial. Dari ulasan tersebut maka penulis menyimpulkan etika berapologi yang urgen dipraktikan saat ini adalah berbahasa sopan, bersikap tenang, menghindari hoaks dan menghindari ujaran kebencian.
PERANAN PEMURIDAN FAMILY CARE TERHADAP PERTUMBUHAN KUALITAS KEROHANIAN JEMAAT DI GEREJA BETHEL INDONESIA TABGHA BATAM CENTER
Authors: Suryady Robertus , Hutagalung Kasmer
Published: November 2023

Penulisan ini bertujuan untuk mengupas mengenai Peranan Pemuridan Family Care (Kelompok Sel), yang bertujuan untuk menghasilkan jemaat yang mengalami bertumbuhan kualitas kerohanian. Pemuridan Family Care sangat berperan penting untuk memuridkan setiap orang percaya. Dalam penulisan karya ilmiah ini di perlukan metode penelitian yang tepat, maka penulis menggunakan metode penelitian kualitatif. Dengan menggunakan dasar teori dari berbagai sumber buku: Lembaga Alkitab Indonesia, Church Growth Through cell Group , kelompok sel, Panduan Kelompok Sel, Cooler Hanbook Modul ABC, Build My home One on One ,Pertumbugan Gereja, pertumbuhan dan pendewasaan pelayanan. Penulis juga melakukan pengambilan data di lapangan dengan metode wawancara kepada partisipan yang berhubungan langsung dengan pemuridan Family Care (ketua pemuridan Family Care, anggota pemuridan Family Care dan Koordinator Family Care) di Gereja Bethel Indonesia Tabgha Rayon 10 Batam.
POLA KEPEMIMPINAN YANG EFEKTIF DAN IMPLIKASINYA TERHADAP MULTIPLIKASI KETUA FAMILY CARE MASA KINI
Authors: Suhendra Suhendra , Aloysius Da Yohanes
Published: November 2023

This writing aims to examine Effective Leadership Patterns, which aims to find out the direct implications for the leadership of today's Family Care Chairs in the process of development and multiplication of both groups and also the leaders who will become the new Family Care Chairs. Becoming an effective leader in the Family Care group is very important so that each congregation can be shepherded well, at the same time the existing congregation is directed and prepared to become an effective leader in this current era.

In writing this scientific work, appropriate research methods are needed, so the author uses qualitative research methods. By using basic theory from various book sources. The author also collected data in the field using interview methods with participants who were in direct contact with the current head of Family Care.
DAMPAK PEMURIDAN BAGI PEMBENTUKAN KARAKTER ANAK-ANAK REMAJA USIA 12-17 TAHUN DI JUNIOR CHURCH GEREJA BETHEL INDONESIA TABGHA BATAM CENTRE
Authors: Lin Steven , Hutahaean Junita elfrida
Published: November 2023

The problem currently being faced is the decline in the character of the teenagers in the junior church. We are aware that currently most of the teenagers are experiencing character crisis problems, they are not controlled by the influence of the development of this era. Therefore, the role of the church is very much needed in controlling the existing character problems. Therefore, it is very important for teenagers to be discipled so that they have the character of Christ which has an impact on social life. Seeing the existing problems, the purpose of this study is to describe discipleship as an effort to build character for young people in the Junior Church. The method used in this research is qualitative. Collecting data through observation and interviews. All participants can understand and participate in the discipleship process that takes place by giving life examples by followers of Christ. From the results of the study, it was found that discipleship carried out at the Junior Church has an impact on shaping the character of young people so that they have values and characters that reflect Christ in them.
Nanoclusters binding energy in diatomic model
Authors: Chkhartishvili Levan
Published: November 2023

There is proposed the general formulation of the diatomic model to calculate nanoclusters binding energy, the key value determining their relative stabilities and, consequently, concentrations in forming processes. The simple special case of practical interest, when all the bond lengths can be assumed to be almost equal each to other is considered in details.
To detect pesticide in Food beverages by Partial Structural Examination of CDs with the help of Fluorescence quenching study
Authors: Dave Pranav , Dutta Gaurav
Published: November 2023

In recent world, there are lots of crimes happen by adding some hazardous or poisonous materials in the food and food beverages. So it is very hard and cost effective to detect those materials. By one step synthesising carbon dots, the hydrothermal method is very accurate and precise. Carbon dots were synthesised by using hydrothermal methods with different precursors (ethanolamine, urea, ammonium thiocynate) while synthesising. Fluorescence quenching study has been done by using spectrofluorophotometer by adding some amount of food beverage in carbon dots solution. The structural property of CDs and the fluorescence quenching study have been examined by UV-vis spectrometer, atomic force microscopy, spectrofluorophotometer and FT-IR. The comparisons of precursors conclude that ethanolamine is the accurate and precise precursor to synthesise carbon dots with limited crystalline size (30nm-40nm). It shows better and less time consuming detection of the pesticide in appy fizz drink. By using ethanolamine batch, the fluorescence graph gradually decreased by adding 20ppm carbon dot solution after each reading.
In vitro Anti-Cancer Effect of Polymeric Nanoparticles Encapsulating Caralluma tuberculata in Cancer Cells
Authors: Fayyaz Mahnoor , Sarwar Usama , Nurjis Farwa , Sarfraz Ali Joham , Tabassum Sobia , Raza Abida
Published: November 2023

Rapidly evolving drug delivery systems employ therapeutic agents (liposomes, polymers, and nanospheres) to achieve optimum therapeutic and targeted effects with declined side effects to cure chronic diseases like cancer. Nano-formulation of a natural product i.e., Caralluma tuberculata (Ct) extract, has been used as an effective combinational therapy with enhanced biocompatibility owing to its strong anti-oxidant, anti-inflammatory, anti-bacterial, and anti-tumor potential. Ct extract was prepared using three solvents (EtOH, MeOH, and CHCl3) amongst which methanolic Ct extract exhibited the highest percentage yield (9.6%). Qualitative phytochemical screening, thin layer chromatography (TLC), and antioxidant assays (DPPH assay and H2O2 assay) were performed. The percentage free radical scavenging values were found to be 86.25% (IC50=140.1μg/ml) and 88% (IC50=14.22μg/ml) at 1000 μg/ml concentration for both assays respectively. Methanolic Ct extract was then encapsulated in chitosan-tripolyphosphate (CS-TPP) nanoparticles using ionic gelation method with an encapsulation efficiency of 87%. Characterization showed uniform size distribution of 140nm particle size using DLS and encapsulation of Ct extract inside CS-TPP nanoparticles was confirmed by UV spectrophotometry and FTIR. Ct loaded CS-TPP nanoparticles showed less than or equal to 5% hemolytic activity at concentrations of 15.62μg/ml, 31.25μg/ml, 62.5μg/ml, and 125μg/ml, suggesting its safer usage at lower concentration. Rhodamine conjugated Ct loaded CS-TPP nanoparticles showed significant uptake efficiency in breast cancer cells compared to control. Ct extract and the nanoformulation were treated against triple negative breast cancer cell lines (Cal-51) for the evaluation of cytotoxicity exhibiting 30-40% (IC50=122.3μg/ml) and up to 75% (IC50=14.39μg/ml) cytotoxicity respectively. The study paves way for the encapsulation of medicinal plants in polymeric nanoparticles to achieve safer and highly efficient drug delivery systems.
Recent Advances of Carbon dots for Treatment of Alzheimer’s and Parkinson’s Diseases
Authors: Mohan Vedhanayagam
Published: November 2023

Neurodegenerative disease (ND) is an irreversible disease among the aged people in worldwide. ND is characterized by a progressive loss of neuron structure and function in the brain due to the formation of extracellular and intracellular misfolded or abnormal protein aggregates (β-amyloid, tau and (α-synuclein)). Numerous therapy strategies have been developed by many researchers to address this issue. However, the majority of the methods had only modest success in clinical studies. Transporting therapeutic molecules or drugs across the Blood- Brain Barrier (BBB) is a substantial problem for neurodegenerative disease diagnosis, targeting, and treatment. As a result, preparation of multifunctional material for simultaneously detecting and treating neurodegenerative diseases are high demand in the biomedical field. Carbon dots (CDs) have recently attracted interest for the diagnosis and treatment of neurodegenerative diseases due to easily crossing the blood[1]brain barrier, biocompatible, biodegradable, enhanced physico-chemical properties, provide tunable surface functionalization and optical properties, higher photostability, smaller size, non-invasiveness, facilitate targeted drug delivery and higher therapeutic efficacy. In this review work, we discussed the current progress of carbon dots in penetrating the blood brain barrier and their application in Alzheimer’s and Parkinson’s disease. Finally, the limitations and future prospects of carbon dots for neurodegenerative diseases are thoroughly examined.
dsRNA Virus Model Molecule and the Mechanism of PRRs and its Research Progress in Female Reproductive Tract Infections
Authors: Pan Yuting , Zhang Yan , Li Xiaoxu , Li Juping , Xu Ling , Wang Wencan , Cui Min , Tian Mingwu
Published: November 2023

Female animal genital tract opening on the body surface, prone to bacterial, viral, parasitic, and other pathogenic microorganism infections, leading to genital tract infectious diseases, such as endometritis, cervicitis, vaginitis, etc. Severe infection can lead to infertility, abortion, and even fetal death. Double-stranded RNA (dsRNA) is an important model molecule, which is widely present in the genome of viruses and generated in the process of virus replication. In mammals, dsRNA is considered to be an innate immune response signal for viral infection, which binds to the corresponding pattern-recognition receptors (PRRs) In vivo and then exerts biological functions. This review summarizes the signal transduction pathway induced by the binding of dsRNA model molecules to PRRs, research status of female genital tract infections and research progress of dsRNA in simulating viral infection in the female genital tract.
Establishing an Online Writing Center for Health Professions Education
Authors: Dehnad Afsaneh , Mohamadzadeh Shirin , Bigdeli Shoaleh , Nemati-Anaraki Leila , Shirazinezhad Hamed , Bagherzadeh Rafat , Sayfouri Nasrin , Ghashghaee Ahmad
Published: November 2023

Purpose: This study aimed to identify the commonly-used modules of Online Writing Centers worldwide to establish the first Online Writing Center in the context of health professions education in Iran. Design/methodology/approach: This observational study was conducted during 2019-2021. In the initial round of search, we identified 61 eligible OWCs whose websites comprised 14 common modules. Then, we searched the top universities according to 2021 Times Higher Education World University Ranking. We probed the modules of the writing centers of the included universities by using a Google form. We identified the modules repeatedly appearing on the websites of the writing centers, and then reviewed the content of each module in order to find a common label which could later be used for constructing our online writing center. Findings: Our final search yielded 26 universities with 22 common modules. The researchers came to a consensus about the modules to be included and the labels assigned to them. Finally, a website was created, and the modules were included. Value of paper: Online Writing Centers scaffold students by giving feedback on word choice errors and assist them in producing grammatically accurate texts. The Online Writing Centers being designed based on the findings of this study can assist many researchers who intend to publish their scientific findings in English.
Analysis of Red Blood Cell Samples using a Handheld Shear-horizontal Surface Acoustic Wave Biosensor
Authors: Thomas Marlon
Published: November 2023

Human red blood cells (RBCs) are highly studied by researchers and clinicians alike because RBCs play an essential role in medical diagnostics. RBCs are the most abundant component of whole blood. The accurate analysis of blood samples for blood cells is crucial to help diagnose and management of several life-threatening diseases. Current techniques for analyzing blood cell counts are time-consuming and expensive, requiring a highly trained technician. Implementing a portable, label-free method enables analysis at small clinics and remote locations with reduced times of analysis and cost. The development of miniature, handheld shear-horizontal surface acoustic wave (SH-SAW) biosensors capable of accurately counting RBCs in liquid samples will improve medical diagnostics in resource-limited regions of the United States and parts of the world where access to centralized clinical laboratories is limited. A shear-horizontal surface acoustic wave is a horizontally polarized surface acoustic wave that is produced by a transducer that is fabricated onto a piezoelectric substrate such as lithium tantalate, lithium niobite, or quartz. We report a lithium tantalate SH-SAW biosensor and method for monitoring the RBC level (hematocrit level) from a whole blood sample using a shear-horizontal surface acoustic wave (SH-SAW) biosensor that uses a 500-picoliter sample well. Samples were introduced by directly pipetting whole blood onto the sample reservoir and washing away any excess material. The SH-SAW biosensor uses an immunoassay, where the antibody anti-glycophorin A is coated on the surface of the active area of the sensor. The sample is compared to a reference sample. Using Microsoft Excel statistical tools, we showed that the results demonstrate the concentration dependence of the samples with an average coefficient of variance (CV) within a sample group was 10% or less for all samples analyzed. Our successful demonstration offers proof of concept for handheld blood cell monitors for remote and resource-limited applications. To our knowledge, this is the first demonstration of an SH-SAW device being used for monitoring red blood cell counts.
Natural Language Processing – Finding the Missing Link for Oncologic Data, 2022
Authors: Krauze Andra , Camphausen Kevin
Published: November 2023

Oncology like most medical specialties, is undergoing a data revolution at the center of which lie vast and growing amounts of clinical data in unstructured, semi-structured and structed formats. Artificial intelligence approaches are widely employed in research endeavors in an attempt to harness electronic medical records data to advance patient outcomes. The use of clinical oncologic data, although collected on large scale, particularly with the increased implementation of electronic medical records, remains limited due to missing, incorrect or manually entered data in registries and the lack of resource allocation to data curation in real world settings. Natural Language Processing (NLP) may provide an avenue to extract data from electronic medical records and as a result has grown considerably in medicine to be employed for documentation, outcome analysis, phenotyping and clinical trial eligibility. Barriers to NLP persist with inability to aggregate findings across studies due to use of different methods and significant heterogeneity at all levels with important parameters such as patient comorbidities and performance status lacking implementation in AI approaches. The goal of this review is to provide an updated overview of natural language processing (NLP) and the current state of its application in oncology for clinicians and researchers that wish to implement NLP to augment registries and/or advance research projects.
A Scalable Algorithm for Interpreting DNA Sequence and Predicting the Response of Killer T-Cells in Systemic Lupus Erythematosus Patients
Authors: Lok Woo Wai , O Ephraim Nwoye , Obinna Fidelis P , O I Nwosu , Jessy Balogun O , Al-Nima Raid Rafi
Published: November 2023

The incidence and prevalence of SLE in North America are 23.2 and 241 per 100,000 people per year respectively while the incidence in Africa is 0.3 per 100,000 people per year. The study aims to predict the autoimmune response of killer T-cells in a patient suffering from Systemic Lupus Erythematosus by searching for variations in genes regulating the activities of Killer T cells. An approximate matching algorithm applying the Boyer-Moore Algorithm for the matching algorithm. Nucleotide sequences of each of the genes liked to Killer T-cells in reference human genome to DNA sequences of SLE patients. The threshold on all single nucleotide polymorphisms (SNPs) is set to 10% of the nucleotide sequence length of the gene. For 50% of susceptibility genes with no match the patient is susceptible. Sixteen (16) patients show that they are all guaranteed to manifest autoimmune Killer T-cells. The algorithm can predict the response of killer T-cells and improve the early detection and treatment of SLE patients. A similar approach can be used for genetically linked diseases like cancer.
A Comparative Analysis of Application of Genetic Algorithm and Particle Swarm Optimization in Solving Traveling Tournament Problem (TTP)
Authors: Haldar Avijit , Mondal Shyama , Mukherjee Alok , Chatterjee Kingshuk
Published: November 2023

Traveling Tournament Problem (TTP) has been a major area of research due to its huge application in developing smooth and healthy match schedules in a tournament. The primary objective of a similar problem is to minimize the travel distance for the participating teams. This would incur better quality of the tournament as the players would experience least travel; hence restore better energy level. Besides, there would be a great benefit to the tournament organizers from the economic point of view as well. A well constructed schedule, comprising of diverse combinations of the home and away matches in a round robin tournament would keep the fans more attracted, resulting in turnouts in a large number in the stadiums and a considerable amount of revenue generated from the match tickets. Hence, an optimal solution to the problem is necessary from all respects; although it becomes progressively harder to identify the optimal solution with increasing number of teams. In this work, we have described how to solve the problem using Genetic algorithm and particle swarm optimization.
Facial Skin Disease Detection using Image Processing
Authors: R Lohith , N Govinda Niharika , K Pruthvi , V Janhavi , HL Gururaj
Published: November 2023

Busy lifestyle, modernization, increasing pollution and unhealthy diet have led to problems which people are neglecting. Not drinking enough water, stress and hormonal changes are causing problems to skin. Causes may be situational or genetic. Few skin conditions are minor while others can be life-threatening. The skin is the largest organ of the body and is composed of water, proteins, fats and minerals. Problems appear on outer layer of the skin that is epidermis. Skin diseases are considered to be the fourth most common cause of human illness. Skin diseases are observed to increase with age and were seen frequently in both men and women. Skin disorders can be temporary or permanent. Skin diseases have an impact on individual, family and social life caused by inadequate self-treatment which may also induce psychological problems. In recent years, use of computer technologies is becoming practically universal for both personal and professional issues. Facial skin problem identification and recognition has evolved to a great extent over the years. Detection of skin diseases is done using Convolution Neural Network (CNN) and image processing methods. CNN yields better performance in terms of accuracy, precision and results than the existing conventional methods. Image processing uses digital computer to process the images through an algorithm. We focus on features like skin tone, skin texture and color. We present a brief review about various facial skin problems providing more insight about the effective models and algorithms used.
The COVID-19 Omicron Wave in the Framework of a New Mathematical Modeling in Few European Countries and the Right Time for Lifting Restrictions
Authors: Petkov Pavel
Published: November 2023

Objectives: The COVID-19 Omicron wave in Romania, Bulgaria and Germany is considered in retrospective till begin of March 2022. The aim is to describe both country specific features and common trends related the same underlying pathogen as well as to compare shortly the results and derived parameters to those from a similar application to few strongly affected countries in the beginning of 2022: the USA, the UK and France. Methods: The main novelty of the approach used to describe the Pandemic is the dynamical tracking of successive generations of infected people instead of treating in time the evolution of few large compartments within which the total population is partitioned. Results: The daily observed new infection cases are described over a large time scale in a reasonable way after normalization and the derived model parameters in all cases are consistent. The position of the calculated Pandemic peaks in time in Romania and Bulgaria indicates a transition from the second to the third generation of infected people while in the larger countries the transition is from the third to the fourth generation. Conclusions: The rapidly acquired temporary immunity and vaccination effects reinforced the expectation of eventually control/stop the COVID-19 Pandemic soon. However, lifting restrictions should have been done carefully and country specifically, and of course at the right time. Later developments after March 2022 have shown that the expectations were too optimistic and Omicron waves generated by another virus sub-variants did complicate the situation.
A review on Epigenome Editing using CRISPR-based Tools to Rejuvenate Skin Tissues
Authors: Sichani Ali Saber , Baneshi Maryam , Ranjbar Maryam , Naeimzadeh Yasaman , Fallahi Jafar
Published: November 2023

Genomic activity is controlled by a sophisticated series of cell functions known as the epigenome. The creation of tools capable of directly altering various processes is required to unravel this intricacy. Additionally, by employing tailored DNA-binding platforms connected with effector domains to serve as targeted transcription factors or epigenetic modifiers, it is possible to control the chemical modifiers that regulate the genome's activity. Neoplastic disorders have received the most attention in the study of epigenetics, though the epigenome's significance in a variety of disease processes is now well acknowledged. Researchers are inspired to investigate novel approaches to revert these pathogenic alterations to their normal patterns by considering the fact that the epigenome profile of individuals with aging skin cells or other skin disorders, including atopic dermatitis, differs from that of healthy individuals. Here in this review, we discuss the use of CRISPR/dCas9 as a cutting-edge and flexible tool for fundamental studies on chromatin structure, transcription regulation, and epigenetic landscapes, as well as the potential of this method in these fields. Furthermore, we review on common and recently invented methods to make epigenetic alterations possible in daughter cells after any mitotic differentiations. In the very near future, CRISPR-based epigenomic editing will become a potent tool for comprehending and regulating biological functions.
Artificial Intelligence in Skin Cancer: A Literature Review from Diagnosis to Prevention and Beyond
Authors: Ghorbani Atousa
Published: November 2023

Artificial Intelligence (AI) in medicine is quickly expanding, offering significant potential benefits in diagnosis and prognostication. While concerns may exist regarding its implementation, it is important for dermatologists and dermatopathologists to collaborate with technical specialists to embrace AI as a tool for enhancing medical decision-making and improving healthcare accessibility. This is particularly relevant in melanocytic neoplasms, which continue to present challenges despite years of experience. Dermatology, with its extensive medical data and images, provides an ideal field for training AI algorithms to enhance patient care. Collaborative efforts between medical professionals and technical specialists are crucial in harnessing the power of AI while ensuring it complements and enhances the existing healthcare framework. By staying informed about AI concepts and ongoing research, dermatologists can remain at the forefront of this emerging field and leverage its potential to improve patient outcomes. In conclusion, AI holds great promise in dermatology, especially in the management and analysis of Skin cancer (SC). In this review we strive to introduce the concepts of AI and its association with dermatology, providing an overview of recent studies in the field, such as existing applications and future potential in dermatology.
Diabetic Retinopathy- Brief Overview
Authors: Le Yun Zheng
Published: November 2023

Diabetic retinopathy (DR) is a major complication of diabetes, which affects over 90 million people worldwide. Lifetime occurrence of DR is over 90% and 50-60% for Type I diabetes mellitus (T1DM) and T2DM, respectively. Such a high prevalence makes DR a leading cause of blindness in working aged people and a major public health issue in developed countries. In the inaugural issue, this editorial provides a brief overview of the salient features of DR, including risk factors, diagnosis, pathobiology, molecular and cellular mechanisms, and therapeutics. Aspects of DR that are critically important, but not commonly known, will also be discussed.
Cyclic Keto: Important Tool to Manage Type 2 Diabetes
Authors: Nanda Priti
Published: November 2023

India is a capital of Diabetes and in the last 25 years the increase in diabetics in India has been very steep. Diabetes is a part of metabolic syndrome and is a very fast spreading lifestyle disease. At the onset, we want to emphasize early diagnosis of this disease as it can help prevent complications of the disease. In cases, when diabetes management is started early it can help us reverse diabetes. The first step to manage diabetes is diet and lifestyle changes. There are several diets recommended for diabetics such as high protein diet, Atkins diet, Low carbohydrate diet, ketogenic diet and cyclic keto diet and many more. In this article we are discussing a case of a diabetic woman who was introduced to cyclic keto and lifestyle therapy as a first line management. This case highlights the importance of cyclic ketogenic diet in management of difficult diabetic cases successfully. The author has described everything in detail to help doctors and patients follow it on their own and see the positive effects of cyclic ketogenic diet in diabetic patients.
Semaglutide as Treatment for Obesity in Adolescents
Authors: Mikhail Nasser , Wali Soma
Published: November 2023

Background: Semaglutide was recently approved to treat obesity in adolescents. Main objective: To provide a critical appraisal of semaglutide as anti-obesity agent in adolescents. Methods: Pubmed search up to May 19, 2023. Search terms were obesity, semaglutide, safety, phentermine/topiramate, liraglutide, dulaglutide, exenatide. Clinical trials, prospective and observational studies were included. Results: The STEP TEENS was a double-blind, randomized trial that evaluated semaglutide 2.4 mg/week in addition to lifestyle changes in 201 adolescents (62% women) with obesity with mean body mass index (BMI) 37.0 kg/m2. After 68 weeks, difference between semaglutide and placebo in reduction of BMI (the primary outcome) was -16.7% (95% CI, -20.3 to -13.2). Corresponding difference in weight loss was -17.7 kg (95% CI, -21.8 to -13.7). Proportions of subjects who had ≥5% weight loss at 68 weeks were 73% and 18% with semaglutide and placebo groups, respectively. In the semaglutide group, reduction in BMI was evident (>5%) after 3 months, reached a nadir in 52-58 weeks then plateaued. Overall, the safety profile of semaglutide in adolescents mimics that in adults, except for higher incidence of gall bladder disease, and allergic reactions (rash and urticaria) in adolescents. Premature discontinuation of treatment due to adverse effects occurred in 5% of semaglutide-treated patients compared with 4% of placebo-treated subjects. Conclusions: Semaglutide is a promising addition to pharmacological therapy of obesity in adolescents. Further studies are needed to demonstrate its long-term efficacy and safety, particularly in various ethnic minorities and in patients with concomitant type 2 diabetes.
ASURANSI DAN PROTEKSI TERHADAP PROGRAM MANEJEMEN ASURANSI SYARIAH DALAM BERMUAMALAH
Authors: Jairin Jairin
Published: November 2023

Asuransi syari'ah merupakan usaha untuk saling melindungi dan tolong menolong diantara sejumlah orang melalui investasi dalam bentuk aset dan atau tabarru' yang memberikan pola pengembalian untuk menghadapi resiko/bahaya tertentu melalui akad yang sesuai dengan syariah. Pada hakikatnya, secara teoritis semangat yang terkandung dala sebuah lembaga asuransi tidak bisa dilepaskan dari semangat sosial dan saling tolong-menolong antara sesama manusia. Tujuan asuransi dari ialah menggeser resiko (kemungkinan menderita kerugian) kepada orang lain atau kepada suatu badan dan pekerjaannya menanggung kerugian orang lain karena kehilangan atau kerusakan dengan mendapatkan premi. Yang dimaksud kehilangan dalam asuransi ialah apabila barang yang dimaksudkan dengan kerusakan, yaitu kalau keadaan barang tanggungan keadaannya (mutu dan kualitasnya) turun. Dari data yang dikelola dari hasil peneilitian ini, maka hasil yang diperoleh dalam penelitian ini adalah bahwa Trade in market pada prinsip tabarru atau bagi hasil yang dijalankan oleh Asurans syariah sangat besar pengaruh terhadap meningkatnya minap masyarakat terhadap program Asuransi Syariah, dibandingkan dengan program teransfer of Risk yang di jalankan oleh program Asuransi konfensional.
Analisis Penerapan Kaidah Ushul dalam Pembangunan Ekonomi Islam di Indonesia
Authors: Padmadhani Felita
Published: November 2023

Ekonomi pembangunan memiliki peran yang sangat vital, ialah sebagai salah satu pedoman dilaksanakannya kebijakan. Selain itu, ekonomi pembangunan juga merupakan instrumen utama dalam rangka membantu mewujudkan pembangunan nasional sebuah negara. Ekonomi Islam merupakan sebuah pendekatan alternatif dalam membantu melaksanakan ekonomi pembangunan. Pembangunan ekonomi Islam merupakan pembangunan kemakmuran ekonomi disebuah negara guna mewujudkan kesejahteraan penduduknya dengan dasar hukum Islam. Dalam membangun sebuah ekonomi, perlu adanya sebuah prinsip agar pembangunan ekonomi yang dilakukan dapat terukur dan terarah sesuai dengan apa yang diharapkan. Dengan menggunakan metode penelitian deskriptif, kami melakukan upaya untuk meneliti keadaan pembangunan ekonomi Islam secara menyeluruh serta mencoba menjabarkan secara sistematis dan fakta terkait berbagai keadaan dan perkembangan terhadap lahirnya pembangunan ekonomi Islam di Indonesia. Hasil dari penelitian ini adalah penerapan kaidah ushul dalam pembangunan ekonomi berdasarkan hukum Islam sudah dilaksanakan sesuai dengan syariat Islam oleh pemerintah.
KEJAHATAN PENCUCIAN UANG DALAM PERSPEKTIF FIQH JINAYAH
Authors: Salsabilla Shofi , Wati Arum Fadilah , Muti’ah Muti’ah
Published: November 2023

As time progresses, technology becomes more advanced, along with that progress does not always have a positive impact on the world and society, in fact sometimes crime is increasingly rampant as well. In the case of money laundering, for example, it is one of the results of the influence of the times, briefly money laundering can be understood to get money from a crime which is then processed in such a way that it looks like clean or holy money again so that it can be used by unscrupulous persons. irresponsible consumer. In this scientific article, the author will briefly analyze the discussion about money laundering or also known as money laundering from the perspective of criminal law as well as the perspective of fiqh jinayah in Islam