bluuebunny/crossref_metadata_2025 huggingface dataset:
Italian Adaption of Self-Perceived Employability Scale: Psychometric Properties and Relations with the Career Adaptability and Well-Being
Authors: Lodi Ernesto , Zammitti Andrea , Magnano Paola , Patrizi Patrizia , Santisi Giuseppe
Published: April 2020

The recent transformation of the workplaces and labor market, characterized by rapid technological changes, social and economic instability, has greatly influenced the construction of people’s career paths. These paths cannot be viewed more as linear, but multifaceted and unstable. In organizational context, the psychological contract has changed from long term to short term. In this scenario, the construct of employability becomes central: people need to maintain and improve their ability to be attractive to the labor market to get or keep a job. The study presents the adaptation of the Self-Perceived Employability Scale to the Italian context. The participants are 660 Italian workers. The instruments used to verify the concurrent validity of the scale were the Employability Scale, the Flourishing Scale, the Satisfaction With Life Scale, the Organizational Satisfaction Questionnaire and the Career Adapt-Abilities Scale. Results showed good psychometric properties of the Italian version in terms of internal consistency, construct and concurrent validity, with significant correlations with all the other measures. The CFA highlights some dissimilarity in the scale’s structure compared to the UK version, probably due to cultural differences among the samples.
Hidden Realities of Infant Feeding: Systematic Review of Qualitative Findings from Parents
Authors: Dattilo Anne M. , Carvalho Ryan S. , Feferbaum Rubens , Forsyth Stewart , Zhao Ai
Published: April 2020

A growing, global conversation, regarding realities and challenges that parents experience today is ever-present. To understand recent parent’s attitudes, beliefs, and perceptions regarding infant feeding, we sought to systematically identify and synthesize original qualitative research findings. Following the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) framework, electronic databases were searched with a priori terms applied to title/abstract fields and limited to studies published in English from 2015 to 2019, inclusive. Study quality assessment was conducted using the Critical Appraisal Skills Programme (CASP) checklist, and thematic analyses performed. Of 73 studies meeting inclusion criteria, four major themes emerged. (1) Breastfeeding is best for an infant; (2) Distinct attitudes, beliefs, and perceptions of mothers that breastfeed, and those that could not or chose not to breastfeed, are evident; (3) Infant feeding behaviors are influenced by the socio-cultural environment of the family, and (4) Parent’s expectations of education and support addressing personal infant feeding choices from health care providers are not always met. This systematic review, guided by constructs within behavioral models and theories, provides updated findings to help inform the development of nutrition education curricula and public policy programs. Results can be applied within scale-up nutrition and behavioral education interventions that support parents during infant feeding.
The Role of the Size of the Small Group and Informal Subgroups in Intragroup Conflicts
Authors: Sidorenkov Andrey V. , Borokhovski Eugene F.
Published: April 2020

This study examines the relationship between (a) the size of groups and the number of informal subgroups in them with conflicts in the context of the group, and (b) the size of the informal subgroups with conflicts in the context of the subgroup. A multidimensional model of intragroup conflict was used, which includes two dimensions: five levels of conflict (i.e., interpersonal (individual–individual), micro-group (individual–subgroup), group (individual–group), subgroup–subgroup, and subgroup–group) and two types of conflict (activity-oriented and subject-oriented). Each level of conflict contains two types. Forty-one small work groups (334 employees) took part in the study. In the group as a whole, both the size of the group and the number of informal subgroups in it have a positive relationship with subgroup–subgroup conflict in both types and subgroup–group subject-oriented conflict, and have a negative connection with micro-group subject-oriented conflict. In turn, the size of the subgroup is positively associated with the two types of subgroup–group conflict and negatively connected with the two types of micro-group conflict, as well as with interpersonal activity-oriented conflict at the level of the informal subgroup.
Front End Projects Benefits Realisation from a Requirements Management Perspective—A Systematic Literature Review
Authors: Serugga Joas , Kagioglou Mike , Tzortzopoulos Patricia
Published: April 2020

The recent notable emergence of a body of research in requirements management on one hand and benefits realisation has contributed to addressing a growing need for improved performance in Architecture, Engineering and Construction (AEC) projects. However, front end design (FED) as one of the vital processes in the project life cycle and delivery has attracted limited research to date within this understanding. This paper aims to map current evidence on requirements management in facilitating benefits realisation from an FED perspective. This is to bring about an updated and unified position on requirements management for its impact on design decision making. A systematic review of the literature covering the last ten years (2008–2018) aims first to build understanding and support identification of these emergent conceptual positions and secondly underscore essential requirements and their categorisations that impact on design discourse in FED. One hundred sixty-one peer-reviewed journal papers in the areas of benefits realisation and/or requirements management and/or FED based are identified on a pre-determined inclusion and exclusion criteria. Thirty-six requirements are identified as important in influencing use case changes important in design decision making broadly grouped into nine major categories. Following analysis, this research finds little evidence supporting an integrated requirements management practice and understanding to support design decision making. The research further finds bias in current research discourse towards four requirements categories (technical, economics, governance and environment); and 14 requirements, dominated by three strategic values, collaboration and project governance, with over 80% share of literature. The least 14 requirements such as “flow of spaces, social status/aspiration, mobility and integrated design” among others only account for less than 10% of literature. The authors argue for new research to bridge this gap, highlight the essential role of requirements management and broaden understanding to improve benefits realisation, particularly for FED processes.
Modulus of Elasticity and Compressive Strength of Tuff Masonry: Results of a Wide Set of Flat-Jack Tests
Authors: Guadagnuolo Mariateresa , Aurilio Marianna , Basile Andrea , Faella Giuseppe
Published: April 2020

The assessment of the modulus of elasticity and compressive strength of masonry is a fundamental step in the seismic analysis of existing structures. In this paper, the representativeness of the values provided by flat-jack tests for tuff masonry is investigated through the analysis of a very large and homogeneous number of tests (635 double flat-jack tests). Data relate to existing buildings belonging to different historical and/or construction periods, located throughout the Campania region (Italy) in areas with different peculiarities. Results are compared with the values provided by Italian Building Code, containing ranges of the elastic modulus and compressive strength for different types of masonry. The values of flat-jack tests are then compared with laboratory tests available in the literature. Finally, comparisons with code equations are performed. It is shown that equations correlating the masonry compressive strength with the modulus of elasticity provide values larger than the mean of experimental data, whereas the equations correlating the masonry compressive strength with the strength of components provide lower values, if block and mortar strengths are varied within a probable and wide range.
Lab-Scale Investigation of Palm Shell Char as Tar Reforming Catalyst
Authors: Chen Yen-Hau , Schmid Max , Chang Chia-Chi , Chang Ching-Yuan , Scheffknecht Günter
Published: April 2020

This research investigated the application of palm shell char as a catalyst for the catalytic steam reforming of tar after the sorption enhanced gasification (SEG) process. The catalytic activities of palm shell char and metal-supported palm shell char were tested in a simulated SEG derived syngas with tar model compounds (i.e., toluene and naphthalene) at a concentration of 10 g m−3 NTP. The results indicated that palm shell char had an experimentally excellent catalytic activity for tar reforming with toluene and naphthalene conversions of 0.8 in a short residence time of 0.17 s at 900 °C. A theoretical residence time to reach the complete naphthalene conversion was 1.2 s at 900 °C for palm shell char, demonstrating a promising activity similar to wood char and straw char, but better than CaO. It was also found that potassium and iron-loaded palm shell chars exhibited much better catalytic activity than palm shell char, while the parallel reaction of gasification of K-loaded palm shell char influenced the conversion with its drastic mass loss. Moreover, contrary to CaO, palm shell char presented relatively low selectivity to benzene, and its spontaneous gasification generated extra syngas. In summary, the present study demonstrated that the low-cost material, palm shell char, can successfully be used as the tar-reforming catalyst after SEG process.
Photoreforming of Glucose over CuO/TiO2
Authors: Bahadori Elnaz , Ramis Gianguido , Zanardo Danny , Menegazzo Federica , Signoretto Michela , Gazzoli Delia , Pietrogiacomi Daniela , Michele Alessandro Di , Rossetti Ilenia
Published: April 2020

Hydrogen production has been investigated through the photoreforming of glucose, as model molecule representative for biomass hydrolysis. Different copper- or nickel-loaded titania photocatalysts have been compared. The samples were prepared starting from three titania samples, prepared by precipitation and characterized by pure Anatase with high surface area, or prepared through flame synthesis, i.e., flame pyrolysis and the commercial P25, leading to mixed Rutile and Anatase phases with lower surface area. The metal was added in different loading up to 1 wt % following three procedures that induced different dispersion and reducibility to the catalyst. The highest activity among the bare semiconductors was exhibited by the commercial P25 titania, while the addition of 1 wt % CuO through precipitation with complexes led to the best hydrogen productivity, i.e., 9.7 mol H2/h kgcat. Finally, a basic economic analysis considering only the costs of the catalyst and testing was performed, suggesting CuO promoted samples as promising and almost feasible for this application.
Acetylation of Eugenol on Functionalized Mesoporous Aluminosilicates Synthesized from Amazonian Flint Kaolin
Authors: de Nazaré de Oliveira Alex , Tallyta Leite Lima Erika , de Aguiar Andrade Eloisa Helena , Zamian José Roberto , Filho Geraldo Narciso da Rocha , Costa Carlos Emmerson Ferreira da , Helena de Oliveira Pires Luíza , Luque Rafael , Nascimento Luís Adriano Santos do
Published: April 2020

The present work was aimed to investigate the catalytic activity of a mesoporous catalyst synthesized from 3-mercaptopropyltrimethoxysilane (MPTS) functionalized Amazonian flint kaolin in the acetylation of eugenol with acetic anhydride. Materials were characterized by thermogravimetry (TGA), N2 adsorption (BET), X-ray dispersive energy spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and acid-base titration. The results presented proved the efficiency of flint kaolin as an alternative source in the preparation of mesoporous materials, since the material exhibited textural properties (specific surface area of 1071 m2 g−1, pore volume of 1.05 cm3 g−1 and pore diameter of 3.85 nm) and structural properties (d100 = 4.35 nm, a0 = 5.06 nm and Wt = 1.21 nm) within the required and characteristic material standards. The catalyst with the total amount of acidic sites of 4.89 mmol H+ g−1 was efficient in converting 99.9% of eugenol (eugenol to acetic anhydride molar ratio of 1:5, 2% catalyst, temperature and reaction time 80 °C and 40 min reaction). In addition, the reused catalyst could be successfully recycled with 92% conversion activity under identical reaction conditions.
Electrocatalytic Degradation of Azo Dye by Vanadium-Doped TiO2 Nanocatalyst
Authors: Chang Jih-Hsing , Wang Yong-Li , Dong Cheng-Di , Shen Shan-Yi
Published: April 2020

In this work, nano V/TiO2 catalysts at different molar ratios were prepared and fabricated as the electrocatalytic electrodes for electrocatalytic degradation. The effect of the vanadium doping on the surface morphology, microstructural, and specific surface area of V/TiO2 catalysts was probed by field emission scanning electron microscope (FESEM) x-ray diffractometer (XRD), and Brunauer–Emmett–Teller (BET), respectively. Afterward, the solution of Acid Red 27 (AR 27, one kind of azo dye) was treated by an electrocatalytic system in which the nano V/TiO2 electrode was employed as the anode and graphite as the cathode. Results demonstrate that AR 27 can be effectively degraded by the nano V/TiO2 electrodes; the highest removal efficiency of color and total organic carbon (TOC) reached 99% and 76%, respectively, under 0.10 VT (molar ratio of vanadium to titanium) condition. The nano V/TiO2 electrode with high specific surface area facilitated the electrocatalytic degradation. The current density of 25 mA cm−2 was found to be the optimum operation for this electrocatalytic system whereas the oxygen was increased with the current density. The electricity consumption of pure TiO2 and nano V/TiO2 electrode in this electrocatalytic system was around 0.11 kWh L−1 and 0.02 kWh L−1, respectively. This implies that the nano V/TiO2 electrode possesses both high degradation and energy saving features. Moreover, the nono V/TiO2 electrode shows its possible repeated utilization.
Diaryliodoniums Salts as Coupling Partners for Transition-Metal Catalyzed C- and N-Arylation of Heteroarenes
Authors: Pacheco-Benichou Alexandra , Besson Thierry , Fruit Corinne
Published: April 2020

Owing to the pioneering works performed on the metal-catalyzed sp2 C–H arylation of indole and pyrrole by Sanford and Gaunt, N– and C-arylation involving diaryliodonium salts offers an attractive complementary strategy for the late-stage diversification of heteroarenes. The main feature of this expanding methodology is the selective incorporation of structural diversity into complex molecules which usually have several C–H bonds and/or N–H bonds with high tolerance to functional groups and under mild conditions. This review summarizes the main recent achievements reported in transition-metal-catalyzed N– and/or C–H arylation of heteroarenes using acyclic diaryliodonium salts as coupling partners.
Correlation between Microstructure and Tribological Properties of Laser Surface Heat-Treated Stellite Coatings
Authors: Park Chang-Kyoo , Lee Jung-Hoon , Kang Nam-Hyun , Chun Eun-Joon
Published: April 2020

To manufacture superior-performance continuous casting mold components, high-velocity oxygen fuel spraying of a Stellite-1 coating was followed by its laser heat treatment at 1373–1473 K using a diode laser. The effects of the laser irradiation conditions on the macro- and microstructural variations along with the hardness and wear resistance within the Stellite-1 coating were evaluated. After the heat treatment, micro-voids within the sprayed coating decreased in number slightly with an increase in the heat treatment temperature. The hardness of the sprayed Stellite-1 coating increased from that of the as-sprayed coating (680 HV) after the laser heat treatment, with a hardness of 860 HV obtained at 1473 K. The cause of the increase in hardness could be the formation of nano-sized W- and Cr-based carbides such as WC, M7C3, and M23C6, as suggested by transmission electron microscopy analysis. The tribological properties of as-sprayed and laser heat-treated samples were investigated by a pin-on-disk tribometer. The laser heat treatment of Stellite-1 coating enhanced wear resistance. This resulted in a lower coefficient of friction and wear rate for the laser heat-treated sample than those for the as-sprayed sample.
Accurate Sampling with Noisy Forces from Approximate Computing
Authors: Rengaraj Varadarajan , Lass Michael , Plessl Christian , Kühne Thomas D.
Published: April 2020

In scientific computing, the acceleration of atomistic computer simulations by means of custom hardware is finding ever-growing application. A major limitation, however, is that the high efficiency in terms of performance and low power consumption entails the massive usage of low precision computing units. Here, based on the approximate computing paradigm, we present an algorithmic method to compensate for numerical inaccuracies due to low accuracy arithmetic operations rigorously, yet still obtaining exact expectation values using a properly modified Langevin-type equation.
Computational Investigation of the Folded and Unfolded Band Structure and Structural and Optical Properties of CsPb(I1−xBrx)3 Perovskites
Authors: Ghaithan Hamid M. , Alahmed Zeyad A. , Lyras Andreas , Qaid Saif M. H. , Aldwayyan Abdullah S.
Published: April 2020

The structural, electronic, and optical properties of inorganic CsPb(I1−xBrx)3 compounds were investigated using the full-potential linear augmented-plane wave (FP-LAPW) scheme with a generalized gradient approximation (GGA). Perdew–Burke–Ernzerhof generalized gradient approximation (PBE-GGA) and modified Becke–Johnson GGA (mBJ-GGA) potentials were used to study the electronic and optical properties. The band gaps calculated using the mBJ-GGA method gave the best agreement with experimentally reported values. CsPb(I1−xBrx)3 compounds were wide and direct band gap semiconductors, with a band gap located at the M point. The spectral weight (SW) approach was used to unfold the band structure. By substituting iodide with bromide, an increase in the band gap energy (Eg) values of 0.30 and 0.55 eV, using PBE-GGA and mBJ-GGA potentials, respectively, was observed, whereas the optical property parameters, which were also investigated, demonstrated the reverse effect. The high absorption spectra in the ultraviolet−visible energy range demonstrated that CsPb(I1−xBrx)3 perovskite could be used in optical and optoelectronic devices by partly replacing iodide with bromide.
The Fracture Behavior and Mechanical Properties of a Support Structure for Additive Manufacturing of Ti-6Al-4V
Authors: Weber Sebastian , Montero Joaquin , Petroll Christoph , Schäfer Tom , Bleckmann Matthias , Paetzold Kristin
Published: April 2020

In the laser powder bed fusion processes for metal additive manufacturing, a support structure is needed to fix the part to the base plate and to support overhanging regions. Currently the importance of support structure for a successful build process is often underestimated and some effects are not yet well understood. Therefore, this study investigates the fracture behavior and mechanical properties of thin additive manufactured struts using the titanium alloy Ti-6Al-4V and specific machine parameters for support structures. Tensile tests were performed for different strut diameters and the fracture surfaces were analyzed using a laser microscope and a scanning electron microscope. Additionally, the porosity was examined with micro-CT scans. The results were compared with a different set of parameters used for solid parts. The experiments revealed that struts produced with support parameters had no significantly lower tensile strength than the comparative parts. Despite that, some porosity and around two percent of defects on the fracture surface for parts using the solid parameter set have been found. Parts with support parameters show no porosity, even though the energy density is around 30% lower compared to the solid parameter set.
Structure of a Luminescent MOF-2 Derivative with a Core of Zn(II)-Terephthalate-Isoquinoline and Its Application in Sensing of Xylenes
Authors: Rosales-Vázquez Luis D. , Bazany Rodríguez Iván J. , Hernández-Ortega Simón , Sánchez-Mendieta Víctor , Vilchis-Nestor Alfredo R. , Cázares-Marinero José de Jesús , Dorazco-González Alejandro
Published: April 2020

A new blue photoluminescent 2D metal–organic framework, 1, with formula {[Zn2(μ2-BDC)2(iQ)2]}∞ has been synthesized in a high yield under solvothermal conditions by reacting Zn(II) ions with 1,4-benzenedicarboxylic acid (H2BDC) and isoquinoline (iQ) in DMF. Compound 1 was thoroughly characterized by single-crystal X-ray diffraction, solid-state cross-polarization magic-angle spinning 13C NMR, X-ray powder diffraction, scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS), and thermoanalysis. The crystal structure of 1 showed interpenetrated 2D frameworks consisting of dinuclear paddle-wheel cores Zn2; moreover, this material possessed thermostability up to 310 °C. The CPMAS 13C-NMR spectrum of 1 is consistent with the symmetry of the crystal structure. Luminescence studies showed that 1 strongly enhances its fluorescence emission in the presence of xylene isomers with a pronounced selectivity to p-xylene.
Fungal Diversity in the Phyllosphere of Pinus heldreichii H. Christ—An Endemic and High-Altitude Pine of the Mediterranean Region
Authors: Lazarević Jelena , Menkis Audrius
Published: April 2020

Pinus heldreichii is a high-altitude coniferous tree species naturaly occurring in small and disjuncted populations in the Balkans and southern Italy. The aim of this study was to assess diversity and composition of fungal communities in living needles of P. heldreichii specifically focusing on fungal pathogens. Sampling was carried out at six different sites in Montenegro, where 2-4 year-old living needles of P. heldreichii were collected. Following DNA isolation, it was amplified using ITS2 rDNA as a marker and subjected to high-throughput sequencing. Sequencing resulted in 31,831 high quality reads, which after assembly were found to represent 375 fungal taxa. The detected fungi were 295 (78.7%) Ascomycota, 79 (21.0%) Basidiomycota and 1 (0.2%) Mortierellomycotina. The most common fungi were Lophodermium pinastri (12.5% of all high-quality sequences), L. conigenum (10.9%), Sydowia polyspora (8.8%), Cyclaneusma niveum (5.5%), Unidentified sp. 2814_1 (5.4%) and Phaeosphaeria punctiformis (4.4%). The community composition varied among different sites, but in this respect two sites at higher altitudes (harsh growing conditions) were separated from three sites at lower altitudes (milder growing conditions), suggesting that environmental conditions were among major determinants of fungal communities associated with needles of P. heldreichii. Trees on one study site were attacked by bark beetles, leading to discolouration and frequent dieback of needles, thereby strongly affecting the fungal community structure. Among all functional groups of fungi, pathogens appeared to be an important component of fungal communities in the phyllosphere of P. heldreichii, especially in those trees under strong abiotic and biotic stress.
TLR4 T399I Polymorphism and Endometriosis in a Cohort of Italian Women
Authors: Marchionni Enrica , Porpora Maria Grazia , Megiorni Francesca , Piacenti Ilaria , Giovannetti Agnese , Marchese Cinzia , Benedetti Panici Pierluigi , Pizzuti Antonio
Published: April 2020

Background: Endometriosis is a widespread multifactorial disease in which environmental, genetic, and epigenetic factors contribute to the phenotype. Single Nucleotide Polymorphisms (SNPs) in genes implicated in pivotal molecular mechanisms have been investigated as susceptible risk factors in distinct populations. Among these, Toll-like receptor 4 (TLR4) represents a good candidate due to its role in the immune/inflammatory response and endometriosis pathogenesis. Methods: The TRL4 gene T399I SNP (C/T transition, rs4986791) was investigated in 236 Italian endometriosis patients and 150 controls by using the PCR-RFLP method. One-tailed Fisher’s exact test was used to compare differences between categorical variables. T399I genotype distribution was evaluated for Hardy–Weinberg equilibrium in both groups using the Chi-squared test for given probabilities. Results: Fisher’s exact test comparing C and T allele frequencies showed a difference in the frequency of T alleles between patients and controls (OR = 1.96, 95% confidence interval 0.91–4.23; p-value = 0.0552). Genotype frequencies did not show any significant difference between patients and controls. The homozygous TT genotype was observed in 2% of endometriosis women and not in controls. Conclusions: Our results show that the TLR4 rs4986791 T variant may be considered a genetic risk factor for endometriosis in Italian women. More extensive studies in other populations are needed to confirm this result.
Increased Vascular Adhesion Protein 1 (VAP-1) Levels Are Associated with Alternative M2 Macrophage Activation and Poor Prognosis for Human Gliomas
Authors: Chang Shu-Jyuan , Tu Hung-Pin , Lai Yen-Chang Clark , Luo Chi-Wen , Nejo Takahide , Tanaka Shota , Chai Chee-Yin , Kwan Aij-Lie
Published: April 2020

Glioma is characterized by a high heterogeneity in the brain tumor. Abundant tumor-associated macrophages (TAMs) exist as neoplastic tissues, implicating tumor plasticity and thus leading to therapeutic challenges. Vascular adhesion protein (VAP-1) potentially serves as a mediator for TAM immunity in tumor milieu. We previously demonstrated that VAP-1 could contribute to tumor malignancy, but its characteristics in TAM immunity of glioma progression are still unclear. This study explored the association of VAP-1 expression with TAM distribution as well as the resulting clinical significance and prognostic value in human gliomas. An in-depth analysis of AOC3 (VAP-1) gene expression was performed using 695 glioma samples derived from the cancer genome atlas (TCGA)-lower grade glioma and glioblastoma (GBMLGG) cohort. Bioinformatic analysis confirmed that VAP-1 expression is associated with poor prognosis of glioma patients (p = 0.0283). VAP-1 and TAM biomarkers (CD68, iNOS, and CD163) were evaluated by immunohistochemistry in 108 gliomas from Kaohsiung Medical University Hospital. VAP-1+ was expressed in 56 (51.85%) cases and this phenotype revealed a significant association with overall survival in Kaplan–Meier analysis (p < 0.0001). Immunohistochemical double staining showed that VAP-1 immunoreactivity was present around CD163+ M2 infiltration location, including aggressive lesions and neighboring neovasculature. We demonstrated that high VAP-1 expression levels positively correlated with CD163+ M2 activation and coexpression of these two proteins was associated with worse survival in gliomas (p < 0.0001). Multivariate analysis indicated that VAP-1 alone and co-expressed with CD163 were the significantly independent indicators (both p < 0.0001). Furthermore, VAP-1/CD163 coexpression exhibited excellent diagnostic accuracy in gliomas (AUC = 0.8008). In conclusion, VAP-1 and TAM CD163 M2 coexpression was found in glioma tissues belonging to a highly malignant subgroup that was associated with poor prognosis. These results implied VAP-1 abundance is closely linked to alternative M2 activation during glioma progression. From the aforementioned data, a reasonable inference is that VAP-1 combined with targeting M2 immunity might be an effective therapeutic target for human gliomas.
Endometrial Cancer Risk Prediction According to Indication of Diagnostic Hysteroscopy in Post-Menopausal Women
Authors: Saccardi Carlo , Vitagliano Amerigo , Marchetti Matteo , Lo Turco Alice , Tosatto Sofia , Palumbo Michela , De Lorenzo Luciana Serena , Vitale Salvatore Giovanni , Scioscia Marco , Noventa Marco
Published: April 2020

We conducted a prospective observational study investigating the clinical relevance of endometrial thickness (ET) and abnormal uterine bleeding (AUB) on endometrial cancer (EC) risk in a cohort of postmenopausal patients undergoing diagnostic hysteroscopy and endometrial biopsy. Patients were divided into two groups according to the indication of diagnostic hysteroscopy: ET_Group (asymptomatic patients with endometrial thickness ≥ 4 mm) and AUB_Group (patients with a history of abnormal uterine bleeding). We further divided the AUB_Group into two subgroups based on endometrial thickness (AUB_Subgroup1: ET < 4 mm; AUB_Subgroup2: ET ≥ 4 mm). The primary outcome was the risk of endometrial cancer and atypical hyperplasia according to the indications of diagnostic hysteroscopy (AUB, ET ≥ 4 mm or both). The secondary outcome was to determine the best cut-off value of endometrial thickness to predict endometrial cancer in asymptomatic postmenopausal women. The prevalence of endometrial cancer and atypical hyperplasia in AUB_Group and ET_Group was 21% and 6.7% respectively. As well as for EC alone, higher prevalence of both conditions was observed in AUB_Subgroup2 (29.3%) in comparison to AUB_Subgroup1 (10.6%; p < 0.001). In asymptomatic patients the cut-off of endometrial thickness that showed the best sensitivity and specificity to diagnose endometrial cancer (100% and 80% respectively) was 11 mm (AUC of 91.4%; Expβ: 1067; CI 95%). In conclusion, considering the high risk of neoplasia, diagnostic hysteroscopy with endometrial biopsy should be mandatory in cases of abnormal uterine bleeding in postmenopausal patients. Moreover, we want to emphasize the need for further evidence stating the clinical relevance of endometrial thickness value in asymptomatic patients and the impact of individual risk factors on endometrial cancer development.
Development of a Deep-Learning-Based Artificial Intelligence Tool for Differential Diagnosis between Dry and Neovascular Age-Related Macular Degeneration
Authors: Heo Tae-Young , Kim Kyoung Min , Min Hyun Kyu , Gu Sun Mi , Kim Jae Hyun , Yun Jaesuk , Min Jung Kee
Published: April 2020

The use of deep-learning-based artificial intelligence (AI) is emerging in ophthalmology, with AI-mediated differential diagnosis of neovascular age-related macular degeneration (AMD) and dry AMD a promising methodology for precise treatment strategies and prognosis. Here, we developed deep learning algorithms and predicted diseases using 399 images of fundus. Based on feature extraction and classification with fully connected layers, we applied the Visual Geometry Group with 16 layers (VGG16) model of convolutional neural networks to classify new images. Image-data augmentation in our model was performed using Keras ImageDataGenerator, and the leave-one-out procedure was used for model cross-validation. The prediction and validation results obtained using the AI AMD diagnosis model showed relevant performance and suitability as well as better diagnostic accuracy than manual review by first-year residents. These results suggest the efficacy of this tool for early differential diagnosis of AMD in situations involving shortages of ophthalmology specialists and other medical devices.
Layout Strengthening the ESD Performance for High-Voltage N-Channel Lateral Diffused MOSFETs
Authors: Fan Sheng-Kai , Chen Shen-Li , Lin Po-Lin , Chen Hung-Wei
Published: April 2020

An electrostatic discharge (ESD) event can negatively affect the reliability of integrated circuits. Therefore, improving on ESD immunity in high-voltage (HV) n-channel (n) lateral diffused metal–oxide–semiconductor field-effect transistor (HV nLDMOS) components through drain-side layout engineering was studied. This involved adjusting the operating voltage, improving the non-uniform turned-on phenomenon, and examining the effects of embedded-device structures on ESD. All proposed architectures for improving ESD immunity in this work were measured and evaluated using a transmission-line pulse system. The corresponding trigger voltage (Vt1), holding voltage (Vh) and secondary breakdown current (It2) results of the tested devices were obtained. This paper first addresses the drift-region length modulation to design different operating voltages, which decreased as the drift region length and shallow trench isolation (STI) length shrunk. When an HV nLDMOS device decreased to the shortest drift region length, the Vt1 and Vh values were closest to 21.85, and 9.27 V, respectively. The It2 value of a low-voltage operated device could be increased to a maximum value of 3.25 A. For the channel width modulation, increasing the layout finger number of an HV LDMOS device did not really help the ESD immunity that because it may suffer the problem of non-uniform turned-on phenomenon. Therefore, adjusting the optimized channel width was the best one method of improvement. Furthermore, to improve the low ESD reliability problem of nLDMOS devices, two structures were used to improve the ESD capability. The first was a drain side—embedded silicon-controlled rectifier (SCR). Here, the SCR PNP-arranged type in the drain side had the best ESD capability because the SCR path was short and had been prior to triggering; however, it also has a latch-up risk and low Vh characteristic. By removing the entire heavily doped drain-side N+ region, the equivalent series resistance in the drain region was increased, so that the It2 performance could be increased from 2.29 A to 3.98 A in the structure of a fully embedded drain-side Schottky diode. This component still has sufficiently high Vh behaviour. Therefore, embedding a full Schottky-diode into an HV nLDMOS in the drain side was the best method and was efficient for improving the ESD/Latch-up abilities of the device. The figure of merit (FOM) of ESD, Latch-up, and cell area considerations improved to approximately 80.86%.
An Energy Efficient Enhanced Dual-Fuzzy Logic Routing Protocol for Monitoring Activities of the Elderly Using Body Sensor Networks
Authors: Park Sea Young , Yun Dai Yeol , Kim TaeHyeon , Lee Jong-Yong , Lee Daesung
Published: April 2020

Wireless body area networks (WBANs) are an important application in wireless sensor networks (WSNs). Specifically, in healthcare monitoring systems, it is important to screen the patient’s biometric signals. For example, the elderlies’ vital signs, such as ECG (Electrocardiogram), blood pressure, heart rate, and blood glucose, can be used as measures of their well-being and are all critically important for remote elderly care in tracking their physical and cognitive capabilities. Therefore, WBANs require higher energy efficiency and data transmission. This paper proposes a cluster-based routing protocol which is suitable for WBANs while analyzing energy efficiency issue in data transmission. Considering the importance of sensor nodes in a specific environment for improving the network’s lifetime, the protocol based on the LEACH (low energy adaptive clustering hierarchy) algorithm is proposed. Due to its avoidance of long-distance transmission, the clustering technique is an efficient algorithm for prolonging the lifetimes of sensor networks. Therefore, this paper suggests an enhanced LEACH-dual fuzzy logic (ELEACH-DFL) protocol based-on clustering for CH (cluster head) selection and cluster configuration in wireless sensor networks. The simulation and analysis results address that the enhanced algorithm reduces the energy consumption effectively and extends the lifespan of the entire network. For wired sensors, attaching sensors to the user may cause problems and inconvenience of mobility. This leads to the use of wireless sensors to proceed with body sensors, which should consider the problem of battery efficiency, which concerns the configuration of wireless sensors. The LEACH protocol is energy efficient until the first node dead is generated. However, there is a sharp drop in energy efficiency after that. The ELEACH-DFL protocol has the advantage of maintaining energy efficiency even after the first node dead is generated, with the utmost consideration being given to stability in consideration of cluster selection and cluster head selection. In a field of 50 × 50, the FND efficiency improvement rate of ELEACH-DFL versus LEACH protocol is approximately 32%. In addition, in a field of 50 × 150, the FND efficiency improvement rate of ELEACH-DFL versus LEACH protocol is approximately 159%.
High-Speed Wide-Range True-Single-Phase-Clock CMOS Dual Modulus Prescaler
Authors: Li Xiaoran , Gao Jian , Chen Zhiming , Wang Xinghua
Published: April 2020

This manuscript presents two novel low-power high-speed true-single-phase-clock (TSPC) prescalers with division ratios of 2/3 and 4/5, respectively, in a standard 90-nm CMOS technology. The logic gates incorporated between the D-flip-flops (DFFs) of a conventional 2/3 prescaler are modified to reduce the propagation delay and hence increase the maximum operating frequency. The measurement results show that the proposed divide-by-2/3 and divide-by-4/5 prescalers can operate up to 17 GHz and 15.3 GHz, respectively, which increase by 5.4 GHz and 4.3 GHz compared with conventional TSPC prescalers. The power of the proposed divide-by-2/3 prescaler is 0.67 mW and 0.92 mW, and 0.87 mW and 1.06 mW for the proposed divide-by-4/5 prescaler. The chip occupies an area of 20 × 35 μm2 and 20 × 50 μm2 for the proposed divide-by-2/3 and divide-by-4/5 prescalers.
Biogeochemical Processes of C and N in the Soil of Mangrove Forest Ecosystems
Authors: Shiau Yo-Jin , Chiu Chih-Yu
Published: April 2020

The mangrove forest provides various ecosystem services in tropical and subtropical regions. Many of these services are driven by the biogeochemical cycles of C and N, and soil is the major reservoir for these chemical elements. These cycles may be influenced by the changing climate. The high plant biomass in mangrove forests makes these forests an important sink for blue C storage. However, anaerobic soil conditions may also turn mangrove forests into an environmentally detrimental producer of greenhouse gases (such as CH4 and N2O), especially as air temperatures increase. In addition, the changing environmental factors associated with climate change may also influence the N cycles and change the patterns of N2 fixation, dissimilatory nitrate reduction to ammonium, and denitrification processes. This review summarizes the biogeochemical processes of C and N cycles in mangrove forest soils based on recently published studies, and how these processes may respond to climate change, with the aim of predicting the impacts of climate change on the mangrove forest ecosystem.
Seasonal Pattern of Stem Diameter Growth of Qinghai Spruce in the Qilian Mountains, Northwestern China
Authors: Wan Yanfang , Yu Pengtao , Li Xiaoqing , Wang Yanhui , Wang Bin , Yu Yipeng , Zhang Lei , Liu Xiande , Wang Shunli
Published: April 2020

It is important to develop a better understanding of the climatic and soil factors controlling the stem diameter growth of Qinghai spruce (Picea crassifolia Kom.) forest. The results will provide basic information for the scientific prediction of trends in the future development of forests. To explain the seasonal pattern of stem diameter growth of Qinghai spruce and its response to environmental factors in the Qilian Mountains, northwest China, the stem diameter changes of 10 sample trees with different sizes and soil and meteorological conditions were observed from May to October of 2015 and 2016. Our results showed that the growth initiation of the stem diameter of Qinghai spruce was on approximately 25 May 2015 and 20 June 2016, and stem diameter growth commenced when the average air and soil temperatures were more than 10 °C and 3 °C, respectively. The cessation of growth occurred on approximately 21 August 2015 and 14 September 2016, and it was probably controlled by soil moisture. Stem diameter growth began earlier, ended later, and exhibited a larger growth rate as tree size increased. For the period May–October, the cumulative stem diameter growth of individual trees was 400 and 380 μm in 2015 and 2016, respectively. The cumulative stem diameter growth had a clear seasonal pattern, which could be divided into three growth stages, i.e., the beginning (from day of year (DOY) 120 to the timing of growth initiation with the daily growth rate of less than 2 μm·day−1), rapid growth (from the timing of growth initiation to the timing of growth cessation with the daily growth rate of more than 2 μm·day−1), and ending stages (from the timing of growth cessation to DOY 300 with the daily growth rate of less than 2 μm·day−1). The correlation of daily stem growth and environmental factors varied with growth stages; however, temperature, vapor pressure deficit (VPD), and soil moisture were the key factors controlling daily stem diameter growth. Overall, these results indicated that the seasonal variation in stem growth was regulated by soil and climatic triggers. Consequently, changes in climate seasonality may have considerable effects on the seasonal patterns of both stem growth and tree growth.
A New Preparation Method of Microfauna from Gypsum: Micropaleontological Association from the Middle Miocene Badenian Gypsum Deposits of Paratethys
Authors: Bojar Hans-Peter , Antoniade Claudia , Barbu Victor , Bojar Ana-Voica
Published: April 2020

Evaporitic gypsum deposits represent an important paleoenvironmental record of the Miocene Badenian of the Carpathian Mountains belt. In this study, we developed a nontoxic method to concentrate calcareous microfossils from gypsum (CaSO4·2H2O), by treating the sulfate with ammonium acetate. We applied the newly developed method to gypsum collected from the Evaporitic Formation outcropping northward of Slănic-Prahova in the Eastern Carpathians. For the first time for this formation, we describe a calcareous microfossil assemblage characterized by the presence of planktonic foraminifera as well as cysts and fragments of calcareous algae.
Late Chronotype is Associated with Adolescent Asthma: Assessment Using the Korean-Version MCTQ
Authors: Han Chang Hoon , Chung Jaeho
Published: April 2020

Objectives: In the study, we explored whether sleep chronotypes are associated with asthma in adolescents. Methods: We analyzed 24,655 physician-diagnosed adolescent asthmatic patients and 253,775 non-asthmatic adolescent patients from the Korea Youth Risk Behavior Web-based Survey (KYRBWS). Socioeconomic factors, health behaviors factors, psychological factors, and sleep parameters were assessed using the Munich Chronotype Questionnaire (MCTQ). Logistic regression after adjusting for multiple confounders was used to explore the association between sleep chronotype and asthma. Results: The asthmatic adolescent group slept less (≤5 h: 24.3% vs. 23.2%) than the non-asthmatic adolescent group. Mean sleep duration (430.6 ± 95.6 vs. 433.5 ± 93.6 min), midpoint of sleep on school-free days (MSF; 255.9 ± 75.9 vs. 258.3 ± 73.6 min), midpoint of sleep on school days (MSW; 199.1 ± 49.1 vs. 200.1 ± 48.4 min), sleep duration on school days (SDW; 398.2 ± 98.1 vs. 400.2 ± 96.8 min), and sleep duration on school-free days (SDF; 511.8 ± 151.9 vs. 516.7 ± 147.2 min) were significantly lower, sleep satisfaction was significantly poorer (low sleep satisfaction: 41.3% vs. 37.5%), and late chronotype was significantly higher in the asthmatic adolescent (21.1% vs. 20.0%). After adjusting for multiple confounders, late chronotype was significantly associated with an increased frequency of adolescent asthma (OR 1.05; 95% CI 1.01–1.09) compared to intermediate chronotypes. Conclusions: Although our study shows a very modest association (OR of 1.05 in the fully adjusted model), we show that the late sleep chronotype is associated with asthma in adolescents in South Korea.
New Insights about Chronic Pelvic Pain Syndrome (CPPS)
Authors: Grinberg Keren , Sela Yael , Nissanholtz-Gannot Rachel
Published: April 2020

Background: Chronic pelvic pain syndrome (CPPS) is one of the common diseases in urology and gynecology. CPPS is a multifactorial disorder where pain may originate in any of the urogynecological, gastrointestinal, pelvic musculoskeletal, or nervous systems. The symptoms of CPPS appear to result from an interplay between psychological factors and dysfunction in the immune, neurological, and endocrine systems. The aim of this article was to present new insight about CPPS in order to raise awareness of nursing and medical staff in the identification and diagnosis of the syndrome and to promote an appropriate treatment for each woman who suffers from CPPS. Methods: A literature review about the factors associated with CPPS and therapeutic interventions for CPPS was conducted. Results: CPPS represents a chronic pain syndrome that combines anatomic malfunction of the pelvic floor muscles with malfunction of pain perception linked with psychological and cognitive factors. Conclusions: The therapeutic interventions in CPPS cases should, consequently, follow a multidisciplinary approach.
The Extent and Nature of Food and Beverage Company Sponsorship of Children’s Sports Clubs in Canada: A Pilot Study
Authors: Pauzé Elise , Ekeh Odera , Potvin Kent Monique
Published: April 2020

Food and beverage marketing is considered a determinant of childhood obesity. Sponsorship is a marketing technique used by the food industry to target young people when they are engaged in sports. The purpose of this study was to document the frequency and nature of food company sponsorship of children’s sports clubs in Ottawa, Canada. Using national data on sports participation, the five most popular sports among Canadian children aged 4–15 years were first selected for inclusion in the study and relevant sports clubs located in Ottawa (Canada) were then identified. Sports club websites were reviewed between September and December 2018 for evidence of club sponsorship. Food company sponsors were identified and classified by food category. Of the 67 sports clubs identified, 40% received some form of food company sponsorship. Overall, sports clubs had 312 commercial and noncommercial sponsors. Food companies constituted 16% of total sponsors and were the second most frequent type of sponsor after sports-related goods, services, and retailers (25%). Fast food restaurants and other restaurants accounted for 45% and 41% of food company sponsors, respectively. Food company sponsorship of children’s sports clubs is frequent with some promoting companies or brands associated with unhealthy foods. Policymakers should consider restricting the sponsorship of children’s sports clubs by food companies that largely sell or promote unhealthy foods.