bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Cooling Performance in a Cylindrical Battery with Single-Phase Direct Contact Cooling under Various Operating Conditions
Authors: Kim Minjun , Ham Jeonggyun , Shin Donghyeon , Cho Honghyun
Published: October 2022

This study compares the performance according to a working fluid, the number of battery cooling block ports, and header width required for cooling according to the application of the direct contact single-phase battery cooling method in a 1S16P battery module and examines the battery cooling performance according to the flow rate under the standard and summer conditions based on an optimized model. The analysis result verified that R134a showed low-pressure drop and high cooling performance as the working fluid of the direct contact single-phase cooling system in the 1S16P battery module, and R134a showed the best cooling and stability when applied with three ports and a 5 mm header. In addition, under 25 °C outdoor conditions, the maximum temperature of the battery and the temperature difference between the batteries at 3 and 5 lpm excluding 1 lpm are 30.5 °C, 4.91 °C, and 28.7 °C, 3.28 °C, indicating that the flow rate of refrigerant was appropriate for battery safety. In contrast, in the summer condition of 35 °C, the maximum temperature of the battery and temperature difference between the batteries were 38.8 °C and 3.27 °C at the R134a flow rate of 5 lpm or more, which was verified as a stable flow condition for battery safety.
Interactions of Torrefaction and Alkaline Pretreatment with Respect to Glucose Yield of Hydrolyzed Wheat Straw
Authors: Tripathi Jaya , Richard Tom L. , Memis Berrak , Demirci Ali , Ciolkosz Daniel
Published: October 2022

Torrefaction is known to reduce the logistical costs of biomass. Torrefied biomass’ prospects as feedstock for fermentation to liquid biofuel are largely unknown. This study investigated the interactions of torrefaction and alkaline pretreatment of wheat straw on glucose yields from enzymatic hydrolysis, including treatment order and the potential for pH to play a role in the process. Across a range of torrefaction severities with temperatures of 200 °C, 220 °C, and 240 °C and durations of 20, 40, and 60 min, torrefaction had a negative impact on glucose yield of wheat straw with or without alkaline pretreatment and regardless of the order of alkaline pretreatment. Alkaline pretreatment after torrefaction results in higher glucose yield than alkaline pretreatment before torrefaction, or by torrefaction alone. Hence, there is the prospect for adding logistical benefits of torrefaction to the bioethanol system if alkaline pretreatment is coupled with torrefaction. Decreasing trend in pH with increase in torrefaction severities was observed for trials without buffer, indicating chemical changes causing the decrease in pH might be associated with the reduction in yield.
Cutaneous Melanoma versus Vulvovaginal Melanoma—Risk Factors, Pathogenesis and Comparison of Immunotherapy Efficacy
Authors: Lorenz Anna , Kozłowski Mateusz , Lenkiewicz Sebastian , Kwiatkowski Sebastian , Cymbaluk-Płoska Aneta
Published: October 2022

Cutaneous melanoma is a relatively common neoplasm, with fairly well understood pathogenesis, risk factors, prognosis and therapeutic protocols. The incidence of this disease is increasing every year. The situation is different for rare malignancies such as vulvar melanomas and for the even rarer vaginal melanomas. The risk factors for vulvovaginal tumors are not fully understood. The basis of treatment in both cases is surgical resection; however, other types of treatments such as immunotherapy are available. This paper focuses on comparing the pathogenesis and risk factors associated with these neoplasms as well as the efficacy of two groups of drugs—anti-PD-L1 and anti-CTLA4 inhibitors—against both cutaneous melanoma and melanoma of the lower genital tract (vulva and vagina). In the case of cutaneous melanoma, the situation looks more optimistic than for vulvovaginal melanoma, which has a much worse prognosis and, as it turns out, shows a poorer response to immune therapy.
Does Aggressive Surgery Mean Worse Quality of Life and Functional Capacity in Retroperitoneal Sarcoma Patients?—A Retrospective Study of 161 Patients from China
Authors: Zhuang Aobo , Fang Yuan , Ma Lijie , Yang Hua , Lu Weiqi , Zhou Yuhong , Zhang Yong , Tong Hanxing
Published: October 2022

The mainstay of treatment for primary retroperitoneal sarcoma (RPS) is surgery. However, whether multiple visceral resection (MVR) affects patients’ quality of life compared with simple tumor resection has not been reported. Patients with primary RPS who underwent radical resection between 2009 and 2021 were included. Patients who were alive at the last follow-up were asked to complete the European Organization for the Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30). The primary endpoint of the study was the global health (GH) score. A total of 161 patients were included, including 77 in the MVR group and 84 in the non-MVR group. When comparing EORTC scores on functional domains and symptom scales between MVR and non-MVR groups, only constipation scores differed (p = 0.011). Comparing GH scores within 6 months after surgery between the two groups, GH was better in non-MVR patients (58.3 vs. 76.4, p = 0.082). However, patients with longer postoperative intervals in the MVR group had higher scores (p < 0.001), and patients with postoperative intervals of more than one year scored similar to those in the non-MVR group (64.7 vs. 59.2, p = 0.522). As the postoperative interval increased, there was an improvement in all indicators in MVR patients, while there was no significant improvement in non-MVR patients. Aggressive surgical approaches impair quality of life within 6 months postoperatively, but the long-term quality of life is similar to that of patients undergoing simple tumor resection. This should be factored into RPS treatment decisions.
Utilization Trend and Comparison of Different Radiotherapy Modes for Patients with Early-Stage High-Intermediate-Risk Endometrial Cancer: A Real-World, Multi-Institutional Study
Authors: Ren Kang , Zou Lijuan , Wang Tiejun , Liu Zi , He Jianli , Sun Xiaoge , Zhong Wei , Zhao Fengju , Li Xiaomei , Li Sha , Zhu Hong , Ma Zhanshu , Sun Shuai , Wang Wenhui , Hu Ke , Zhang Fuquan , Hou Xiaorong , Wei Lichun
Published: October 2022

This study aimed to compare the outcomes of RT modalities among patients who met different HIR criteria based on multicentric real-world data over 15 years. The enrolled patients, who were diagnosed with FIGO I-II EC from 13 medical institutes and treated with hysterectomy and RT, were reclassified into HIR groups according to the criteria of GOG-249, PORTEC-2, and ESTRO-ESMO-ESGO, respectively. The trends in RT modes utilization were reviewed using the Man-Kendall test. The rate of VBT alone increased from zero in 2005 to 50% in 2015, which showed a significant upward trend (p < 0.05), while the rate of EBRT + VBT utilization declined from 87.5% to around 25% from 2005 to 2015 (p > 0.05). There were no significant differences in OS, DFS, LRFS, and DMFS between VBT alone and EBRT ± VBT in three HIR cohorts. Subgroup analyses in the GOG-249 HIR cohort showed that EBRT ± VBT had higher 5-year DFS, DMFS, and LRFS than VBT alone for patients without lymph node dissection (p < 0.05). Thus, VBT could be regarded as a standard adjuvant radiation modality for HIR patients. EBRT should be administrated to selected HIR patients who meet the GOG-249 criteria and did not undergo lymph node dissection.
Comparison of Extractive and Heteroazeotropic Distillation of High-Boiling Aqueous Mixtures
Authors: Frolkova Anastasia V. , Frolkova Alla K. , Gaganov Ivan S.
Published: October 2022

The processes of extractive distillation and heteroazeotropic distillation of mixtures containing water and a high-boiling component (propionic acid, acetic acid, 1-methoxy-2-propanol) are compared. Entrainers declared in the literature as effective agents for these processes were selected as separating agents. A distillation process simulation in AspenPlus V.11.0 is made. Parametric optimization is carried out and the column operation parameters (number of stages, feed stage, reflux ratio) that meet the minimum energy consumptions and ensure the production of marketable substances are determined. It is shown that the process of heteroazeotropic distillation is more energy-efficient compared to extractive distillation by more than 50%, due to the introduction of an entrainer that lowers the boiling point of process. In addition, in some cases (acetic acid + water with vinyl acetate, propionic acid + water with hexane, cyclohexane, cyclohexanol), one of the columns in the separation flowsheet can be abandoned due to the significantly limited mutual solubility.
The Intention to React to Sounds Induces Sleep Disturbances and Alters Brain Responses to Sounds during Sleep: A Pilot Study
Authors: Combertaldi Selina Ladina , Wick Anna Zoé , Rasch Björn
Published: October 2022

Background: Pre-sleep intentions to react to stimuli during sleep affect sleep processes in spite of reductions in conscious awareness. Here, we compare influences of sounds presented during sleep (with and without intentions to react) with the effect of pre-sleep intentions on sleep (with and without sounds being present during sleep). Methods: Twenty-six young, healthy participants spent two experimental nights in the sleep laboratory. On one night, they were instructed to react to sounds during sleep (“on call”); on the other night, not (“neutral”). Unknown to the subjects, sounds were presented at a low volume in both nights in one group. No sound was presented in any of the two nights in the other group. Results: The instruction of being “on call” decreased objective sleep efficiency independently of sounds being present or not. In addition, event-related responses to sounds as well as slow-wave activity were reduced when being “on call”. Conclusions: Pre-sleep intentions to react impair sleep independently of sounds actually being present and influence brain responses to sounds during sleep. Our results highlight the importance of subjective relevance for reducing negative impact of external noise sources such as traffic or church bells.
Towards Reliable Baselines for Document-Level Sentiment Analysis in the Czech and Slovak Languages
Authors: Mojžiš Ján , Krammer Peter , Kvassay Marcel , Skovajsová Lenka , Hluchý Ladislav
Published: October 2022

This article helps establish reliable baselines for document-level sentiment analysis in highly inflected languages like Czech and Slovak. We revisit an earlier study representing the first comprehensive formulation of such baselines in Czech and show that some of its reported results need to be significantly revised. More specifically, we show that its online product review dataset contained more than 18% of non-trivial duplicates, which incorrectly inflated its macro F1-measure results by more than 19 percentage points. We also establish that part-of-speech-related features have no damaging effect on machine learning algorithms (contrary to the claim made in the study) and rehabilitate the Chi-squared metric for feature selection as being on par with the best performing metrics such as Information Gain. We demonstrate that in feature selection experiments with Information Gain and Chi-squared metrics, the top 10% of ranked unigram and bigram features suffice for the best results regarding online product and movie reviews, while the top 5% of ranked unigram and bigram features are optimal for the Facebook dataset. Finally, we reiterate an important but often ignored warning by George Forman and Martin Scholz that different possible ways of averaging the F1-measure in cross-validation studies of highly unbalanced datasets can lead to results differing by more than 10 percentage points. This can invalidate the comparisons of F1-measure results across different studies if incompatible ways of averaging F1 are used.
Fabrication of PbO2 Electrodes with Different Doses of Er Doping for Sulfonamides Degradation
Authors: Zheng Tianyu , Wei Chunli , Chen Hanzhi , Xu Jin , Wu Yanhong , Xing Xuan
Published: October 2022

In the present study, PbO2 electrodes, doped with different doses of Er (0%, 0.5%, 1%, 2%, and 4%), were fabricated and characterized. Surface morphology characterization by SEM-EDS and XRD showed that Er was successfully doped into the PbO2 catalyst layer and the particle size of Er-PbO2 was reduced significantly. Electrochemical oxidation of sulfamerazine (SMR) in the Er-PbO2 anode system obeyed te pseudo first-order kinetic model with the order of 2% Er-PbO2 > 4% Er-PbO2 > 1% Er-PbO2 > 0.5% Er-PbO2 > 0% PbO2. For 2% Er-PbO2, kSMR was 1.39 h−1, which was only 0.93 h−1 for 0% PbO2. Effects of different operational parameters on SMR degradation in 2% Er-PbO2 anode system were investigated, including the initial pH of the electrolyte and current density. Under the situation of an initial pH of 3, a current density of 30 mA·cm−2, a concentration of SMR 30 mg L−1, and 0.2 M Na2SO4 used as supporting electrolyte, SMR was totally removed in 3 h, and COD mineralization efficiency was achieved 71.3% after 6 h electrolysis. Furthermore, the degradation pathway of SMR was proposed as combining the active sites identification by density functional calculation (DFT) and intermediates detection by LC-MS. Results showed that Er-PbO2 has great potential for antibiotic wastewater treatment in practical applications.
Dancing for Health and Wellbeing: A Feasibility Study of Examining Health Impacts of Online Dancing among Pulmonary Fibrosis Patients
Authors: Niranjan Vikram , Tarantino Giampiero , Kumar Jaspal , Cassidy Nicola , Galvin Liam , O’Dowd Gemma , Barnes Tracey , O’Neill Finola , Cullen Matthew , O’Connor Ray , O’Regan Andrew
Published: October 2022

Background: Physical activity (PA) is recommended in the management of patients with pulmonary fibrosis (PF) to improve health outcomes. Dance is one such form of PA which is meaningful, valuable, enjoyable and has demonstrated positive physical and mental health effects. Methods: With pre-post design, 16 patients, members of the Irish Lung Fibrosis Association, were enrolled in this study. Once weekly, 75-min dance sessions were delivered for eight weeks via Zoom by an experienced choreographer. Participants completed Chronic Respiratory Questionnaire Self-Administered Standardised Format (CRQ-SAS) and European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L) to assess self-rated quality of life. A paired-sample t-test was employed to assess the mean differences between the pre-and post-intervention scores. Results: Most patients (78.57%) were aged over 60 years; with 71.43% diagnosed with pulmonary fibrosis more than 3 years ago. We performed an analysis of 10/16 participants who completed the intervention (5 males, 5 females). On CRQ-SAS scale we found, (a) dyspnoea—small to moderate magnitude improvement of 0.5–1.0 among 50%, (b) fatigue—small to moderate magnitude improvement of 0.5–1.0 among 40%, (c) emotional function—small to high magnitude improvement of 0.5–2.0 among 50%, (d) mastery—small magnitude improvement of 0.5 among 20%. Participants reported their health moderate to best on Visual Analogue Scale of EQ-5D-3L which improved by 1–3 scale among 40%. Mental health improved as percentage of not feeling anxious or depressed rose post event from 42.86% to 72.73%. Conclusion: Our findings demonstrate that a virtual dance intervention is acceptable, enjoyable and feasible for improving health outcomes among PF patients. More organised and continuous events in future may reveal cost-benefit ratio and impact on health outcomes.
Mortality Risk Stratification in Emergency Surgery for Obstructive Colon Cancer—External Validation of International Scores, American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator (SRC), and the Dedicated Score of French Surgical Association (AFC/OCC Score)
Authors: Mihailov Raul , Firescu Dorel , Constantin Georgiana Bianca , Mihailov Oana Mariana , Hoara Petre , Birla Rodica , Patrascu Traian , Panaitescu Eugenia
Published: October 2022

Background: The increased rates of postoperative mortality after emergency surgery for obstructive colon cancer (OCC) require the use of risk-stratification scores. The study purpose is to external validate the surgical risk calculator (SRC) and the AFC/OCC score and to create a score for risk stratification. Patients and methods: Overall, 435 patients with emergency surgery for OCC were included in this retrospective study. We used statistical methods suitable for the aimed purpose. Results: Postoperative mortality was 11.72%. SRC performance: strong discrimination (AUC = 0.864) and excellent calibration (11.80% predicted versus 11.72% observed); AFC/OCC score performance: adequate discrimination (AUC = 0.787) and underestimated mortality (6.93% predicted versus 11.72% observed). We identified nine predictors of postoperative mortality: age > 70 years, CHF, ECOG > 2, sepsis, obesity or cachexia, creatinine (aN) or platelets (aN), and proximal tumors (AUC = 0.947). Based on the score, we obtained four risk groups of mortality rate: low risk (0.7%)—0–2 factors, medium risk (12.5%)—3 factors, high risk (40.0%)—4 factors, very high risk (84.4%)—5–6 factors. Conclusions: The two scores were externally validated. The easy identification of predictors and its performance recommend the mortality score of the Clinic County Emergency Hospital of Galați/OCC for clinical use.
Women’s Access to Kidney Transplantation in France: A Mixed Methods Research Protocol
Authors: Adoli Latame , Raffray Maxime , Châtelet Valérie , Vigneau Cécile , Lobbedez Thierry , Gao Fei , Bayer Florian , Campéon Arnaud , Vabret Elsa , Laude Laëtitia , Jais Jean-Philippe , Daugas Eric , Couchoud Cécile , Bayat Sahar
Published: October 2022

Kidney transplantation is the best renal replacement therapy (medically and economically) for eligible patients with end-stage kidney disease. Studies in some French regions and in other countries suggest a lower access to the kidney transplant waiting listing and also to kidney transplantation, once waitlisted, for women. Using a mixed methods approach, this study aims to precisely understand these potential sex disparities and their causes. The quantitative study will explore the geographic disparities, compare the determinants of access to the waiting list and to kidney transplantation, and compare the reasons and duration of inactive status on the waiting list in women and men at different scales (national, regional, departmental, and census-block). The qualitative study will allow describing and comparing women’s and men’s views about their disease and transplantation, as well as nephrologists’ practices relative to the French national guidelines on waiting list registration. This type of study is important in the current societal context in which the reduction of sex/gender-based inequalities is a major social expectation.
The Role of the Social Determinants of Health on Engagement in Physical Activity or Exercise among Adults Living with HIV: A Scoping Review
Authors: Safa Farhana , McClellan Natalia , Bonato Sarah , Rueda Sergio , O’Brien Kelly K.
Published: October 2022

Physical activity (PA) and exercise are an effective rehabilitation strategy to improve health outcomes among people living with HIV (PLWH). However, engagement in exercise among PLWH can vary. Our aim was to characterize the literature on the role of social determinants of health (SDOH) on engagement in PA or exercise among adults living with HIV. We conducted a scoping review using the Arksey and O’Malley Framework. We searched databases between 1996 and 2021. We included articles that examined PA or exercise among adults with HIV and addressed at least one SDOH from the Public Health Agency of Canada Framework. We extracted data from included articles onto a data extraction charting form, and collated results using content analytical techniques. Of the 11,060 citations, we included 41 articles, with 35 studies involving primary data collection 23 (66%) quantitative, 8 (23%) qualitative, and four (11%) mixed methods. Of the 14,835 participants, 6398 (43%) were women. Gender (n = 24 articles), social support (n = 15), and income and social status (n = 14) were the most commonly reported SDOH in the literature with the majority of studies addressing only one SDOH. Future research should consider the intersection between multiple SDOH to better understand their combined impact on engagement in PA or exercise among PLWH.
Economic Evaluation of Screening Strategy for Latent Tuberculosis Infection (LTBI) in Contacts of Tuberculosis Patients: Systematic Review and Quality Assessment
Authors: Yoopetch Panida , Chitpim Natthakan , Jittikoon Jiraphun , Udomsinprasert Wanvisa , Thavorncharoensap Montarat , Youngkong Sitaporn , Praditsitthikorn Naiyana , Mahasirimongkol Surakameth , Chaikledkaew Usa
Published: October 2022

A tuberculin skin test (TST) or interferon-gamma release assay (IGRA) can be used to screen for latent tuberculosis infection (LTBI). Due to its low cost, TST has been used particularly in underdeveloped countries. The limitations of TST were poor specificity in populations with a high prevalence of Bacille Calmette-Guérin (BCG) vaccination and variability of test readers. IGRA is used as an alternative to TST in settings where higher costs can be supported. The lack of studies conducted in high TB incidence countries since previous review, and using relevant assessment tools of the quality appraisal make the need for updated studies and a more comprehensive systematic review. This study aimed to conduct a systematic review of published economic evaluations of screening strategies for LTBI in contacts of TB patients, assess the quality of these studies, and compare the assessment results related to a country’s income level in order to provide information to other countries. The databases were searched in January 2022 including MEDLINE and Scopus. Two independent reviewers evaluated the included studies based on eligibility criteria, data extraction, and quality assessment. Eleven economic evaluations of LTBI diagnostic tests in TB contacts were included. Most studies were conducted in high-income countries (91%) and used cost-effectiveness analysis methods (73%). The quality assessment of reporting and data sources was appropriate, ranging from 71% to 89%. Interventions varied from study to study. The outcomes were cost per life years gained (27%), cost per quality-adjusted life year gained (27%), cost per TB case prevented (36%), and cost per close contact case (10%). In high-income countries which were not countries with high TB burden, the use of IGRA alone for screening TB contacts was cost-effective, whereas TST was cost-effective in only two studies. In comparison to TST, IGRA could reduce false-positive results, resulting in fewer patients undergoing TB treatment and preventive treatment.
Canada First Nations Strengths in Community-Based Primary Healthcare
Authors: Kyoon Achan Grace , Eni Rachel , Phillips-Beck Wanda , Lavoie Josée G. , Kinew Kathi Avery , Katz Alan
Published: October 2022

Introduction: First Nation (FN) peoples and communities in Canada are still grappling with the effects of colonization. Health and social inequities result in higher disease burden and significant disparities in healthcare access and responsiveness. For resilience, survival, and self-determination, FN are looking inwards for strengths. This paper reports on the cultural, community, and family strengths that have supported FN communities in developing community-based primary healthcare (CBPHC) strategies to support health and wellbeing. Methods: The study was a partnership between university-based researchers; The First Nations Health and Social Secretariat of Manitoba; and eight First Nation communities in Manitoba. Community-based participatory research methods were used to engage the participating communities. One hundred and eighty-three in-depth, semi-structured key informant interviews were completed between 2014 and 2016 with key members of the First Nation communities, i.e., community-based health providers and users of primary healthcare services, representing all age and genders. Data-collection and analysis were conducted following iterative grounded theory analysis. Results: Community-based healthcare models based on local strengths support easier access and shorter wait times for care and compassionate care delivery. Resources such as homecare and medical transportation are helpful. Community cooperation, youth power, responsive leadership, and economic development as well as a strong cultural and spiritual base are key strengths supporting health and social wellbeing. Conclusions: Locally led, self-determined care adds strength in FN communities, and is poised to create long-lasting primary healthcare transformation.
Exploring Depression among the Elderly during the COVID-19 Pandemic: The Effects of the Big Five, Media Use, and Perceived Social Support
Authors: Li Yang , Lin Zhi , Wu Yibo
Published: October 2022

The mental health of the elderly is vulnerable during public health emergencies, such as the COVID-19 pandemic, and the risks of depression is increased. The study aimed to explore the effects of physical health, the Big Five personality traits, media use, and different kinds of perceived social support as predictors of levels of depression among the elderly during the COVID-19 pandemic. A cross-sectional survey was conducted in more than 120 cities in China with a sample of 1147 older adults, and hierarchical regression was established to examine the predictors of the level of depression. The results showed that almost half of the elderly (48%) had a status of mild or much more severe depression during the COVID-19 pandemic. The level of depression was negatively associated with physical health, extraversion, conscientiousness, agreeableness, and family support, while it was positively associated with neuroticism and media use. The study emphasized the effects of physical health, the Big Five personality traits, media use, and perceived social support from family as the predictors of levels of depression, providing further measures to help the elderly better react to a public health emergency.
Effect of Green Plants on Individuals’ Mental Stress during the COVID-19 Pandemic: A Preliminary Study
Authors: Liu Tao , He Lin , Yu Wenhuan , Freudenreich Thomas , Lin Xianhao
Published: October 2022

The COVID-19 pandemic has not only jeopardized people’s physical health, but also put additional strain on their mental health. This study explored the role of indoor natural elements (i.e., green plants) in relieving individuals’ mental stress during a prolonged stressful period. A pilot and three formal studies examined the effect of indoor green plants placed in living and working environments on people’s perceived stress during the pandemic and further uncovered its underlying mechanism emphasizing a mediating role of emotion. The pilot study confirmed that the severity of the pandemic positively correlated with individuals’ level of stress. Study 1 then demonstrated that indoor green plants in people’s living environments might reduce their perceived stress during the pandemic, which is referred to as the “plant effect”. Study 2 repeated the plant effect in a field experiment conducted in a working environment and Study 3 revealed a mediating role of positive emotion. This study provides preliminary evidence for the mitigating effect of indoor green plants on individuals’ mental stress during the COVID-19 pandemic period. The indoor green plants placed in living and working environments may elicit positive emotion, which in turn reduce people’s mental stress. In addition, our results reveal that growth status of the indoor green plants affected the plant effect as well.
Influence of CaO on Physical and Environmental Properties of Granulated Copper Slag: Melting Behavior, Grindability and Leaching Behavior
Authors: Sun Lijun , Feng Yan , Wang Daolin , Qi Chongchong , Zeng Xuemin
Published: October 2022

Due to its potential pozzolanic activity, granulated copper slag (GCS) has been proven to act as a supplementary cementitious material (SCM) after thermochemical modification with CaO. This modification method reduces cement consumption and CO2 emissions; however, the additional energy consumption and environmental properties are also not negligible. This paper aims to evaluate the economics and environmental properties of thermochemically modified GCS with CaO through the melting temperature, grindability, and heavy metal leaching characteristics. The X-ray fluorescence spectroscopy (XRF) results indicated that the composition of the modified GCS shifted to the field close to that of class C fly ash (FA-C) in the CaO-SiO2-Al2O3 ternary phase diagram, demonstrating higher pozzolanic activity. The test results on melting behavior and grindability revealed that adding CaO in amounts ranging from 5 wt% to 20 wt% decreased the melting temperature while increasing the BET surface area, thus significantly improving the thermochemical modification’s economics. The unconfined compressive strength (UCS) of the cement paste blended with 20 wt% CaO added to the modified GCS after curing reached 17.3, 33.6, and 42.9 MPa after curing for 7, 28, and 90 d, respectively. It even exceeded that of Portland cement paste at 28 d and 90 d curings. The leaching results of blended cement proved that the heavy metal elements showed different trends with increased CaO content in modified GCS, but none exceeded the limit values. This paper provides a valuable reference for evaluating thermochemically modified GCS’s economics and environmental properties for use as SCM.
Personal Traits of the People Who Help: The Case of Bystanders to Violence against Women
Authors: Sánchez-Prada Andrés , Delgado-Alvarez Carmen , Bosch-Fiol Esperanza , Ferreiro-Basurto Virginia , Ferrer-Perez Victoria
Published: October 2022

Within the context of emergency situations, the terms witness or bystander are used to refer to individuals involved in oppressive incidents who are neither the victim nor the perpetrator. Among the different types of emergency situations, our study focuses on violence against women (VAW). In keeping with current efforts in the scientific literature on bystander intervention and the evidence currently available, the main focus of this study is to analyze some personal factors that reflect the characteristics or experiences of bystanders and that could have a bearing on their predisposition to help victims of VAW (i.e., empathy, a just world belief system, and expectations of self-efficacy) and later analyze the possible relationship between these personal characteristics and gender or previous experience as a VAW bystander. An opportunity sample of 546 Spanish participants (73.4% women and 26.6% men) between 18 and 56 years of age took part in this study and fill out a sociodemographic data sheet, a questionnaire to evaluate the experience as violence witness designed ad hoc, and the Characteristics of People who Help Questionnaire scale (CPHQ). The results obtained indicate that CPHQ could constitute an adequate measure for the three dimensions analyzed. Female participants are significantly more empathetic than males, but in the case of a just world belief and expectations of self-efficacy the results showed no gender-related differences. Additionally, only a just world belief was clearly influenced by having been a bystander to some form of VAW. In conclusion, this study contributes a proposal for an evaluating instrument featuring three relevant personal characteristics in the development of helping behaviors, presenting some results of interest regarding empathy, a just world belief, and expectations of self-efficacy and their relationship with gender or previous experiences as VAW bystanders. These results obtained suggest an initial path toward future research in the development of interventions with bystander participation in our environment.
Evaluation and Prediction of Ecological Sustainability in the Upper Reaches of the Yellow River Based on Improved Three-Dimensional Ecological Footprint Model
Authors: Guo Jing
Published: October 2022

Ecological footprint is an important method for regional sustainable assessment. Scientific assessment of the ecological sustainability of the upper reaches of the Yellow River is of great significance to the realization of a win–win situation for the ecological environment protection and economic development of the entire Yellow River basin. Based on the improved three-dimensional ecological footprint model, this paper measures and spatially portrays the ecological footprint per capita depth (EFdepth), ecological footprint per capita size (EFsize), and ecological footprint per capita 3D (per capita EF3D) of the upper Yellow River region from 2011 to 2020. Then, the ecological footprint diversity index (EFDI), integrated land stress index (Icomprehensive), ecological stress index (ETI), and ecological coordination coefficient (ECC) are used to evaluate its ecological safety and sustainability. The results of the study indicate that: (1) From 2011 to 2020, the three-dimensional ecological footprint of all provinces and regions in the upper reaches of the Yellow River was in a fluctuating upward trend as a whole, and NMG had the highest growth, from 2.6256 hm2/person to 3.3163 hm2/person, with an average annual growth rate of 2.36%. (2) In the past 10 years, the ETI index of the upper reaches of the Yellow River increased from 2.13 in 2011 to 3.28 in 2020, which is a serious insecurity. The EFDI index fluctuates slightly, but increases year by year. (3) The capital flow occupancy rate of the upper reaches of the Yellow River has been above 86.67%, and fluctuated during the study period, reaching a peak of 88.61% in 2020. (4) In the four periods, the number of land comprehensive pressure states and ecological security pressure states of the provinces and regions in the upper reaches of the Yellow River show a distribution pattern that the northeast region is better than the southwest region. This study is expected to provide scientific reference for land use in the upper reaches of the Yellow River, building the ecological security barrier of the Qinghai Tibet Plateau, and promoting sustainable socio-economic development.
Ecological Responses of Maize Rhizosphere to Antibiotics Entering the Agricultural System in an Area with High Arsenicals Geological Background
Authors: Li Mengli , Chen Yongshan , Feng Ying , Li Xiaofeng , Ye Lili , Jiang Jinping
Published: October 2022

Metal(loid)s can promote the spread and enrichment of antibiotic resistance in the environmental ecosystem through a co-selection effect. Little is known about the ecological effects of entering antibiotics into the environment with long-term metal(loid)s’ resistance profiles. Here, cow manure containing oxytetracycline (OTC) or sulfadiazine (SA) at four concentrations (0 (as control), 1, 10, and 100 mg/kg) was loaded to a maize cropping system in an area with high a arsenicals geological background. Results showed that exogenous antibiotics entering significantly changed the nutrient conditions, such as the concentration of nitrate nitrogen, ammonium nitrogen, and available phosphorus in the maize rhizosphere soil, while total arsenic and metals did not display any differences in antibiotic treatments compared with control. Antibiotics exposure significantly influenced nitrate and nitrite reductase activities to reflect the inhibition of denitrification rates but did not affect the soil urease and acid phosphatase activities. OTC treatment also did not change soil dehydrogenase activities, while SA treatment posed promotion effects, showing a tendency to increase with exposure concentration. Both the tested antibiotics (OTC and SA) decreased the concentration of arsenite and arsenate in rhizosphere soil, but the inhibition effects of the former were higher than that of the latter. Moreover, antibiotic treatment impacted arsenite and arsenate levels in maize root tissue, with positive effects on arsenite and negative effects on arsenate. As a result, both OTC and SA treatments significantly increased bioconcentration factors and showed a tendency to first increase and then decrease with increasing concentration. In addition, the treatments decreased translocation capacity of arsenic from roots to shoots and showed a tendency to increase translocation factors with increasing concentration. Microbial communities with arsenic-resistance profiles may also be resistant to antibiotics entering.
Zearalenone-Induced Mechanical Damage of Intestinal Barrier via the RhoA/ROCK Signaling Pathway in IPEC-J2 Cells
Authors: Huang Biying , Wang Jingjing , Gu Aixin , Wang Tianhu , Li Jianping , Shan Anshan
Published: October 2022

Zearalenone (ZEN) is a widespread contaminant of cereals and agricultural products which causes food safety issues. Ingesting food or feed contaminated with ZEN can disrupt the intestinal epithelial barrier function. The RhoA/ROCK signaling pathway plays a key role in regulating the epithelial barrier function, but studies on such roles have rarely focused on the intestine. The aim of this experiment was to investigate the exact mechanism of ZEN-induced intestinal barrier damage and whether the RhoA/ROCK signaling pathway is involved. The results showed that ZEN significantly induced alkaline phosphatase (AP) activity and FITC–dextran (4 kDa) passage across the epithelial barrier, which significantly reduced the transepithelial resistance (TEER). Meanwhile, ZEN could induce the significantly down-regulated mRNA expression of tight junction proteins (occludin, claudin-1, ZO-1, and claudin-3) and redistribution of ZO-1 immunofluorescence. Further studies demonstrated that ZEN exposure activated the RhoA/ROCK signaling pathway, significantly up-regulated the mRNA expression of ROCK1, the main effector of the signaling pathway, the protein expression of phosphorylated myosin light chain (MLC) and myosin light chain kinase (MLCK), and relatively increased the activity of ATP in cells, simultaneously remodeling the cytoskeleton (F-actin). Overall, our study indicated that ZEN induced intestinal barrier dysfunction by activating the RhoA/ROCK signaling pathway.
The Roles of Calcium Ions in Parkinson’s Disease: Calcium Channel Inhibitors as a Novel Agents?
Authors: Alam Md Reyaz , Raj Khadga , Singh Shamsher
Published: October 2022

Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons, which results in motor impairment. The rationale and objective of the review article is to determine whether CCBs use contributes to a lower risk of developing a first-time diagnosis of PD. Ca2+ homeostasis disruption and mitochondrial dysfunction play a vital role in PD aetiology. In addition, the L-type voltage-gated calcium channel is expressed at high levels amongst nigral neurons, and could play a role in the pathogenesis of PD. In the dopaminergic neurons, Ca2+ entry through plasma membrane Cav1 channels drives a sustained feed-forward stimulation of mitochondrial oxidative phosphorylation. This study investigates the therapeutic potential of R- and T-type Ca2+ channel inhibition in light of new preclinical and clinical data and the feasibility of available Ca2+ channel blockers to cure PD progression. The R-type calcium channel is a type of voltage-dependent calcium channel. Available findings suggest that calcium homeostasis in dopaminergic neurons might be a valuable target for developing new drugs for PD patients. The limitations of our study include reports of observational studies with different follow-up periods. The specific roles of individual drugs and doses were also not mentioned because of nonreporting in the studies.
Development of Artificial-Neural-Network-Based Permanent Deformation Prediction Model of Unbound Granular Materials Subjected to Moving Wheel Loading
Authors: Hua Wenjun , Yu Qunding , Xiao Yuanjie , Li Wenqi , Wang Meng , Chen Yuliang , Li Zhiyong
Published: October 2022

The majority of existing regression models for unbound granular materials (UGMs) consider only the effects of the number of loading cycles and stress levels on the permanent deformation characteristics and are thus unable to account for the complexity of plastic deformation accumulation behavior influenced by other factors, such as dry density, moisture content and gradation. In this study, research efforts were made to develop artificial-neural-network (ANN)-based prediction models for the permanent deformation of UGMs. A series of laboratory repeated load triaxial tests were conducted on UGM specimens with varying gradations to simulate realistic stress paths exerted by moving wheel loads and study permanent deformation characteristics. On the basis of the laboratory testing database, the ANN prediction models were established. Parametric sensitivity analyses were then performed to evaluate and rank the relative importance of each factor on permanent deformation behavior. The results indicated that the developed ANN prediction model is more accurate and reliable as compared to previously published regression models. The two major factors influencing the magnitude of accumulated plastic deformation of UGMs are the shear stress ratio (SSR) and the number of loading cycles, of which the calculated influence coefficients are 38% and 41%, respectively, while the degree of influence of gradation is twice that of the confining pressure.
Synthesis of Gold Nanoparticles from Gold Coatings Recovered from E-Waste Processors
Authors: Su-Gallegos Javier , Magallón-Cacho Lorena , Ramírez-Aparicio Jeannete , Borja-Arco Edgar
Published: October 2022

This work presents the synthesis of Au nanoparticles from gold coatings recovered from processor pins with minimal waste generation. The process consisted of four main steps: (1) physical recovery of pins, (2) recovery of gold coatings by acid digestion, (3) synthesis of HAuCl4 under mild conditions and, (4) synthesis of Au nanoparticles by the Turkevich method. The small dimensions of Au coatings allowed the synthesis of HAuCl4 with lower amounts of HClconc and HNO3conc than those used with aqua regia. This method has significant advantages, such as lower NO2(g) emission, easy post-treatment and purification, low synthesis cost and high yields. Gold nanoparticles synthesized from HAuCl4 were characterized by transmission electron microscopy (TEM) and UV-Vis spectroscopy. Size distribution analysis showed particles 14.23 nm in length and 12.05 nm in width, while absorption spectra showed a surface plasmon located at 523 nm; these characteristics were very similar to those observed with Au nanoparticles obtained with Aldrich’s reagent. It is suggested that recycling procedures can be improved by taking into account the size and shape of the metals to be recovered, thus introducing a new field of research known as hydronanometallurgy.
Titanium Implant Surface Effects on Adherent Macrophage Phenotype: A Systematic Review
Authors: Pitchai Manju , Ipe Deepak , Tadakamadla Santosh , Hamlet Stephen
Published: October 2022

Immunomodulatory biomaterials have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling responses as opposed to persistent inflammation and scar tissue formation. As such, the controlled activation of macrophages and modulation of their phenotype through implant surface modification has emerged as a key therapeutic strategy. Methods: Online databases were searched for in vitro studies between January 1991 and June 2020 which examined the effect of titanium implant surface topography on the adherent macrophage phenotype at either the gene or protein level. Results: Thirty-nine studies were subsequently included for review. Although there was significant heterogeneity between studies, treatment of titanium surfaces increased the surface roughness or hydrophilicity, and hence increased macrophage attachment but decreased cell spreading. Physical coating of the titanium surface also tended to promote the formation of cell clusters. Titanium and titanium-zirconium alloy with a micro- or nano-scale rough topography combined with a hydrophilic surface chemistry were the most effective surfaces for inducing an anti-inflammatory phenotype in adherent macrophages, as indicated by significant changes in cytokine gene expression and or cytokine secretion profiles. Conclusions: The published data support the hypothesis that incorporation of specific topographical and physiochemical surface modifications to titanium can modulate the phenotypic response of adherent macrophages.
Solubility and Thermodynamic Properties of Febuxostat in Various (PEG 400 + Water) Mixtures
Authors: Alghaith Adel F. , Mahdi Wael A. , Haq Nazrul , Alshehri Sultan , Shakeel Faiyaz
Published: October 2022

The solubility of the poorly soluble medicine febuxostat (FXT) (3) in various {polyethylene glycol 400 (PEG 400) (1) + water (H2O) (2)} mixtures has been examined at 298.2–318.2 K and 101.1 kPa. FXT solubility was measured using an isothermal method and correlated with “van’t Hoff, Apelblat, Buchowski–Ksiazczak λh, Yalkowsky–Roseman, Jouyban–Acree, and Jouyban–Acree-van’t Hoff models”. FXT mole fraction solubility was enhanced via an increase in temperature and PEG 400 mass fraction in {(PEG 400 (1) + H2O (2)} mixtures. Neat PEG 400 showed the highest mole fraction solubility of FXT (3.11 × 10–2 at 318.2 K), while neat H2O had the lowest (1.91 × 10–7 at 298.2 K). The overall error value was less than 6.0% for each computational model, indicating good correlations. Based on the positive values of apparent standard enthalpies (46.72–70.30 kJ mol−1) and apparent standard entropies (106.4–118.5 J mol−1 K−1), the dissolution of FXT was “endothermic and entropy-driven” in all {PEG 400 (1) + H2O (2)} mixtures examined. The main mechanism for FXT solvation in {PEG 400 (1) + H2O (2)} mixtures was discovered to be an enthalpy-driven process. In comparison to FXT-H2O, FXT-PEG 400 showed the strongest molecular interactions. In conclusion, these results suggested that PEG 400 has considerable potential for solubilizing a poorly soluble FXT in H2O.
The Synthesis of Metal–Organic-Framework-Based Ternary Nanocomposite for the Adsorption of Organic Dyes from Aqueous Solutions
Authors: Alsaiari Norah Salem , Osman Haitham , Amari Abdelfattah , Tahoon Mohamed A.
Published: October 2022

In the present study, a ternary magnetic nanocomposite (SiO2/MnFe2O4/ZIF-8) was synthesized via the embedding of the SiO2/MnFe2O4 nanocomposite within the metal–organic framework (ZIF-8). The synthesized nanocomposite was characterized using suitable techniques including FT-IR, XRD, SEM, TEM, VSM, and BET. The nanocomposite showed a high surface area (SBET = 831 m2·g−1) and superparamagnetic behavior (23.7 emu·g−1). All characterization techniques confirmed the successful combination of three nanocomposite parts (MnFe2O4, SiO2, and ZIF-8). The nanocomposite was examined for the adsorption of organic dyes, malachite green (MG) and methyl red (MR), from aqueous solutions. The adsorption conditions including ionic strength, contact time, pH, and adsorbent dosage were optimized by studying their change effect. The SiO2/MnFe2O4/ZIF-8 nanocomposite showed high adsorption capacities (1000.03 and 1111.12 mg/g) for the removal of MG and MR, respectively, from water. The isotherm and kinetics studies indicated that the adsorption of MG and MR dyes on the surface of the SiO2/MnFe2O4/ZIF-8 nanocomposite followed the Langmuir isotherm model and pseudo-second-order kinetic model, suggesting the monolayer chemisorption mechanism. The reusability study of up to five successive cycles indicated the successful reuse of the SiO2/MnFe2O4/ZIF-8 adsorbent for dye removal from wastewater. The comparison of the present adsorbent to the previously reported adsorbents indicated that it is a promising adsorbent for dye adsorption from wastewater and must be investigated in the future for the removal of additional pollutants.