bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of the First Highly Selective Inhibitor of Human Lactate Dehydrogenase B
Authors: shibata sachio , Sogabe Satoshi , Miwa Masanori , Fujimoto Takuya , Takakura Nobuyuki , Naotsuka Akihiko , Kitamura Shuji , Kawamoto Tomohiro , Soga Tomoyoshi
Published: November 2020

Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+ and has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell proliferation in oxidative and glycolytic cancer cells. To our knowledge, selective inhibitors for LDHB have yet to be reported. Here, we developed a high-throughput mass spectrometry screening system using an LDHB enzyme assay by detecting NADH and NAD+. The screening campaign identified a small-molecule LDHB selective inhibitor AXKO-0046, an indole derivative. It exhibited uncompetitive LDHB inhibition (IC50 = 42 nM). X-ray crystallography identified its binding with the potential allosteric site away from the LDHB catalytic active site, suggesting that targeting the tetramerization interface of the two dimers is critical for enzymatic activity. AXKO-0046 and its derivatives can be used to validate LDHB-associated pathways in cancer metabolism.
Removal of heavy metals using a wetland batch system with Carrizo (Phragmites Australis)
Authors: Guzman Maribel , Romero Maggy , Flores Michael , Bravo Sebastian
Published: November 2020

One of the greatest environmental issues related to the development of the mining activity is the generation of Acid Mine Drainage (AMD). This effluent generated by active and abandoned mines in Peru produces multiple discussions about the role of the industry for a sustainable development. Many methods have been developed for AMD treatment, being wetlands a good option for heavy metal removal. In this sense, removal of heavy metal by using laboratory constructed wetlands with Phragmites Australis was studied. During a 9-day period the variation of different physicochemical parameters and heavy metals concentrations was recorded. The pH decreased to a constant value of 8.24 after the sixth day. The electrical conductivity presented a slight variation from 1 to 1.33 µS cm-1 on the ninth day. Moreover, fluctuating values of Dissolved Oxygen and Turbidity were observed. A reduction between 69% and 93% of ammonia nitrogen (NH3-N) was registered. Cu concentration was reduced in 68% and 87%; Zn concentrations dropped in 53% and 95%; and Pb was reduced in 20% and 55%. It was concluded that Phragmites Australis can be an alternative in the treatment of the contaminants produced by AMD.
A moon-sized, highly magnetised and rapidly rotating white dwarf may be headed toward collapse
Authors: Caiazzo Ilaria , Burdge Kevin , Fuller James , Heyl Jeremy , Kulkarni Shri , Prince Thomas , Richer Harvey , Schwab Josiah , Andreoni Igor , Drake Andrew , Duev Dmitry , Helou George , Mahabal Ashish , Masci Frank , Smith Roger , Soumagnac Maayane
Published: November 2020

White dwarfs represent the last stage of evolution for low and intermediate-mass stars (below about 8 times the mass of our Sun), and like their stellar progenitors, they are often found in binaries. If the orbital period of the binary is short enough, energy losses from gravitational wave radiation can shrink the orbit until the two white dwarfs come into contact and merge. Depending on the masses of the coalescing white dwarfs, the merger can lead to a supernova of type Ia, or it can give birth to a massive white dwarf. In the latter case, the white dwarf remnant is expected to be highly magnetised due to the strong dynamo that may arise during the merger, and rapidly rotating due to conservation of the orbital angular momentum of the binary. Here we report the discovery of a white dwarf, ZTF J190132.9+145808.7, which presents all these properties, but to an extreme: a rotation period of 6.94 minutes, one of the shortest measured for an isolated white dwarf, a magnetic field ranging between 600 MG and 900 MG over its surface, one of the highest fields ever detected on a white dwarf, and a stellar radius of
1810 km, slightly larger than the radius of the Moon.
Such a small radius implies the star's mass is the closest ever detected to the white dwarf maximum mass, or Chandrasekhar mass. In fact, as the white dwarf cools and its composition stratifies, it may become unstable and collapse due to electron capture, exploding into a thermonuclear supernova or collapsing into a neutron star. Neutron stars born in this fashion could account for 10% of their total population.
Transition of Inflammatory Bowel Disease Patients from Pediatric to Adult Care: An Observational Study on a Joint-Visits Approach
Authors: Corsello Antonio , Pugliese Daniela , Bracci Fiammetta , Knafelz Daniela , Papadatou Bronislava , Aloi Marina , Cucchiara Salvatore , Guidi Luisa , Gasbarrini Antonio , Armuzzi Alessandro
Published: November 2020

BackgroundTransition from pediatric to adult care of patients affected by Inflammatory Bowel Disease (IBD) is a critical step that needs specific care and multidisciplinary involvement. The aim of our study was to evaluate the outcome of the transition process of a cohort of IBD patients, exploring their readiness and the consequent impact on quality of life.MethodsThis observational study followed transitioned patients up for a minimum of 18 months after the beginning of transition process, from January 2014 to April 2019. Transition was carried-out through joint visits pediatricians and adult gastroenterologists. Clinical data before and after transition were collected. A subgroup of patients was submitted to an anonymous online questionnaire of 38 items drawn up based on the validated questionnaires TRAQ and SIBDQ within the first 6 months from the beginning of transition process.ResultsEighty-two patients with IBD were enrolled, with a mean age at transition of 20.2±2.7 years. Before transition, 40.2% of patients already had major surgery and 64.6% started biologics. At transition, 24% of patients were in moderate to severe active phase of their disease and 40% of them had already been treated with ≥ 2 biologics. The mean value of the TRAQ questionnaires was 3.4±0.5 and the mean score of SIBDQ was 53.9±9.8. A significant association was found between a TRAQ mean score > 3 and a SIBDQ > 50 (p=0.0129). Overall, 75% of patients had a positive opinion of the transition model adopted.ConclusionsA strong association has been found between TRAQ and SIBDQ questionnaires, showing how transition readiness has a direct impact on the quality of life of the young adult with IBD.
Phylogenetic analysis of the caspase family in bivalves: implications for programmed cell death, immune response and development
Authors: Vogeler Susanne , Carboni Stefano , Li Xiaoxu , Joyce Alyssa
Published: November 2020

Background: Apoptosis is an important process for an organism’s innate immune system to respond to pathogens, while also allowing for cell differentiation and other essential life functions. Caspases are one of the key protease enzymes involved in the apoptotic process, however there is currently a very limited understanding of bivalve caspase diversity and functions. Results: In this work, we investigated the presence of caspase homologs using a combination of bioinformatics and phylogenetic analyses. We blasted the Crassostrea gigas genome for caspase homologs and identified thirty-five potential homologs in the addition to the already cloned twenty-three bivalve caspases. As such, we present information about the phylogenetic relationship of all identified bivalve caspases in relation to their homology to well-established vertebrate and invertebrate caspases. Our results reveal unexpected novelty and complexity in the bivalve caspase family. Notably, we were unable to identify direct homologues to the initiator caspase-9, a key-caspase in the vertebrate apoptotic pathway, inflammatory caspases (caspase-1,-4 or -5) or executioner caspases-3, -6, -7. We also explored the fact that bivalves appear to possess several unique homologs to the initiator caspase groups -2 and -8. Large expansions of caspase-3 like homologues (caspase-3A-C), caspase-3/7 group and caspase-3/7-like homologues were also identified, suggesting unusual roles of caspases with direct implications for our understanding of immune response in relation to common bivalve diseases. Furthermore, we assessed the gene expression of two initiator (Cg2A, Cg8B) and four executioner caspases (Cg3A, Cg3B, Cg3C, Cg3/7) in C. gigas late-larval development and during metamorphosis, indicating that caspase expressions vary across the different developmental stages.Conclusion: Our analysis provides the first overview of caspases across different bivalve species with essential new insight into caspase diversity, knowledge that can be used for further investigations into response to pathogens or regulation of developmental processes.
Perceptions of Environmental Health and Willingness to Compost Fresh Cut Floral Waste by Retail Flower Shop Owners
Authors: Etheredge Coleman L. , Waliczek Tina M.
Published: November 2020

In the United States there has been a push to convert industries to a more environmentally sustainable business attitude in recent years. Environmentally sustainable practices are not only good for the environment, but there is increasing evidence these practices lead to an increase in customer loyalty. The trend of self-regulation, willingly imposing more stringent environmental policies than required by the government, is progressing toward a time where environmentally friendly practices will be a competitive necessity for businesses to survive. The main purpose of this research was to investigate the perceptions of environmental health of retail flower shop owners and their willingness to recycle fresh cut floral waste produced at retail flower shops for use as compost and to determine if there is a statistical correlation between environmental awareness and willingness to compost fresh cut flower waste. A mailing list of retail florists from across the United States was compiled. A total of 1974 florists from all 50 states were sent a standardized e-mail explaining the purpose of the study. Embedded in the e-mail was a hyperlink that redirected willing respondents to the survey. Each person on the mailing list was emailed one time. Of the 300 retail florists who took part in the survey, a majority, 190 (63.33%), were ranked as having “high concern” for environmental health. A majority of florists 247 (82.33%) “agreed” or “strongly agreed” to collaborate with Master Gardener programs and other organizations if it meant they could recycle their floral waste through composting. Through the creation of industry- and state-sponsored certifications, florists could brand and promote their business as more environmentally conscious by composting their floral waste. This could possibly, in turn, stimulate sales and increase profit margins while having the added benefit of reducing the amount of waste entering landfills.
Modified quasi-stationary method for studying changes in transition temperatures of diesel engine pistons coated with heat-shielding materials
Authors:   Belgorod State National Research University, Al-Bdeiri Mahmood , Krasilnikov Vladimir ,   Belgorod State National Research University, Sergeev Sergey ,   Belgorod State National Research University
Published: November 2020

The purpose of the work is to identify complex transient heat flow paths in the combustion chamber of engine, significantly improve the models of diesel engine heat flow, and study the effect of aluminum oxide coating by the galvanic plasma method on short-term and long-term reactions of the piston head. The analysis of operation of aluminum alloy coated diesel engine piston is carried out using a modified quasi -steady method and a finite element method. A thermodynamic analysis is presented using energy and state equations with corresponding gas heat transfer. Time-dependent boundary conditions are set on the gas-blown surfaces of 2D finite element transition models of combustion chamber components. It is shown that this methodology can reveal complex transient paths of the heat flow in engine combustion chambers and distribution details of heat losses in various cooling media. Numerical simulation has shown that the maximum temperature increase relative to the uncoated piston is 64.3% for the coating thickness of 0.13 mm. Tests have shown that the coatings can endure up to 280 thermal cycles. It is found out that predictions of numerical simulation are in good agreement with the results of experiments conducted with repaired pistons. The experimental operation of Cummins КТА 38 engines at Chernogorsk and Vostochno-Beysk coal mines has shown that the engine equipped after repair with the piston coated with aluminum applied by the galvanic plasma method has been in operation for 2 years and 3 months, whereas its set overhaul period is 18,000 hours. Therefore, the proposed methodology allows to reduce temperature variations in the piston and, thereby increase the service life of engine pistons coated with the use of the thermal barrier coating technology.
Provjera latentne strukture Revidiranog upitnika kvalitete interakcija roditelj-dijete
Authors:   Filozofski fakultet, Sveučilište u Splitu, Split, Kardum Goran , Reić Ercegovac Ina ,   Filozofski fakultet, Sveučilište u Splitu, Split
Published: November 2020

Cilj ovoga rada bio je na hrvatskom uzorku studenata provjeriti latentnu strukturu Revidiranog upitnika procjene kvalitete interakcija roditelj – dijete, inačica za djecu (PACHIQ-R, Lange, Evers, Jansen i Dolan, 2002). U ovom je istraživanju sudjelovalo 388 studenata, a primijenjeni su postupci paralelne analize, konfirmatorne analize i strukturalno modeliranje kako bi se provjerila latentna struktura upitnika jer u ranijoj primjeni na širokom dobnom uzorku nije potvrđen pretpostavljeni teorijski model od dva faktora. Rezultati konfirmatorne analize ne podržavaju dvofaktorsku strukturu za obje inačice Upitnika, dok paralelna analiza upućuje na više faktora. Eksploratorna i naknadna konfirmatorna analiza modela potvrđuje postojanje jednog općeg faktora s najvećim opterećenjima te tri faktora s manjim brojem značajnih opterećenja. Jednofaktorski model bez određenog broja čestica značajno se razlikuje od jednofaktorskog i dvofaktorskog modela sa svim česticama te ima bolje parametre pristajanja. Pouzdanost Upitnika je visoka; omega-h modela na Upitniku za procjenu odnosa s majkom iznosi 0,87, uz ukupni omega od 0,93, a na inačici za oca omega-h modela iznosi 0,86 uz ukupni omega 0,95. Doprinos ovog rada ogleda se u nalazu koji upućuje na jednu latentnu dimenziju odnosa i prema ocu i majci, a ne kako autori pretpostavljaju dvije dimenzije, prihvaćanje i rješavanje konflikata. Također je potrebno pri određivanju latentnih dimenzija biti oprezan u odabiru i tumačenju nalaza faktorske analize te ponoviti istraživanje uz moguću reviziju broja čestica pri korištenju jedne dimenzije. Ključne riječi: interakcija dijete - roditelj, PACHIQ-R, faktorska analiza, paralelna analiza
Uloga strategija emocionalnog napora u objašnjenju izgaranja nastavnika
Authors:   Odjel za psihologiju, Sveučilište u Zadru, Zadar, Slišković Ana , Burić Irena ,   Odjel za psihologiju, Sveučilište u Zadru, Zadar, Bubić Lucija
Published: November 2020

Iako su prediktori i ishodi izgaranja u različitim profesijama, uključujući nastavničku, relativno česta tema istraživanja, uloga strategija emocionalnog napora u objašnjenju sržnih dimenzija izgaranja manje je istraživana, osobito kod hrvatskih nastavnika. Stoga je cilj ovog istraživanja bio ispitati ulogu strategija emocionalnog napora (dubinska strategija, te dvije površinske strategije: prikrivanje osjećaja i glumljenje emocija) u objašnjenju iscrpljenosti i otuđenosti nastavnika. U istraživanju je sudjelovalo ukupno 1955 nastavnika, od čega 581 učitelj razredne nastave, 716 nastavnika predmetne nastave u osnovnoj školi, te 538 srednjoškolskih nastavnika. U uzorku su bile zastupljenije nastavnice (1648 nastavnica i 307 nastavnika), a raspon dobi se kretao od 23 do 68 godina (M = 42,38, SD = 10,12). Rezultati su pokazali značajan, iako relativno malen, doprinos strategija emocionalnog napora u objašnjenju izgaranja na poslu. Pri tome nastavnici koji češće koriste površinske strategije emocionalnog napora (prikrivanje i glumljenje osjećaja) imaju više razine iscrpljenosti i otuđenosti. Suprotno tome, korištenje dubinske strategije emocionalnog napora vezano je za niže razine izgaranja. Ključne riječi: strategije emocionalnog napora, izgaranje, nastavnici
Samoregulacija i pisano izražavanje
Authors:   Odjel za nastavničke studije u Gospiću, Sveučilište u Zadru, Gospić, Nikčević-Milković Anela
Published: November 2020

U radu je obrazložena uloga samoregulacijskih procesa pisanoga izražavanja kao vrlo zahtjevne, složene i temeljne (meta)kognitivne vještine te sposobnosti kako u učenju jezika, tako i u cjeloživotnome učenju. Obrazovna i društvena važnost pisanoga izražavanja očituje se u činjenici da je provjera i vrednovanje učeničkoga pisanja sastavni dio svih vanjskih nacionalnih ispita. Glavna svrha ovoga članka je u analitičko-sintetičkom i kritičkom sagledavanju recentnijih spoznaja iz područja pisanoga izražavanja i to njegovih kognitivnih i metakognitivnih odrednica, s naglaskom na ulogu samoregulacijskih procesa. U prvome poglavlju pisano izražavanje objašnjeno je sa psihološkoga (kognitivnoga, metakognitivnoga i motivacijskoga) te fiziološkoga aspekta. Potom je u središnjem poglavlju objašnjena uloga samoregulacije u području pisanja i strategija kojima se ona ostvaruje. S obzirom na to da postoje velike rodne razlike u vještini i procesima pisanoga izražavanja u korist ženskoga roda, one se objašnjavaju i potkrepljuju nizom istraživanja u narednome poglavlju. Na kraju se navode instrukcijski pristupi i treninzi poučavanja pisanoga izražavanja u skladu sa socijalno-konstruktivističkim pristupom učenju koji učenicima i studentima, po uzoru na anglosaksonsku obrazovnu praksu, mogu pomoći u postizanju sve većih kompetencija pisanoga izražavanja. Ovo je vrlo važno jer je pisano izražavanje jedno od najtežih generativnih ljudskih vještina i sposobnosti koje treba naučiti. Ključne riječi: pisano izražavanje, kognitivne i metakognitivne odrednice, samoregulacijski procesi, strategije i tehnike pisanja, rodne razlike u motivaciji i postignućima pisanja, instrukcijski pristupi i treninzi poučavanja pisanoga izražavanja
Školsko postignuće i zadovoljstvo školom s obzirom na osobne značajke, strategije učenja i korištenje digitalnih medija u učenju
Authors:   Odjel za nastavničke studije u Gospiću, Sveučilište u Zadru, Gospić, Nikčević-Milković Anela
Published: November 2020

Cilj ovog istraživanja bio je ispitati objektivan i subjektivan školski uspjeh učenika s obzirom na neke sociodemografske varijable učenika (dob, obrazovna razina, rod), crte ličnosti, strategije učenja te korištenje digitalnih medija (DM) u učenju i nastavi. Rezultati pokazuju da učenici 6. i 8. razreda osnovne škole imaju viši objektivan školski uspjeh u odnosu na učenike 2. razreda srednje škole te da učenici 6. razreda OŠ više koriste adaptivne strategije dubokog kognitivnog procesiranja informacija (DKP) i maladaptivne strategije površinskog kognitivnog procesiranja informacija (PKP). Učenici 6. i 8. razreda OŠ viši su na osobini Ugodnosti, a veća ugodnost znači i veće zadovoljstvo školom. Ekstravertiraniji su učenici 6. razreda OŠ i 2. razreda SŠ u odnosu na učenike 8. razreda OŠ. Učenice te učenici s višim objektivnim i subjektivnim školskim uspjehom otvoreniji su, ali su ovi potonji i neurotičniji. Učenice, učenici 6. razreda OŠ te učenici s višim objektivnim školskim uspjehom savjesniji su te više koriste adaptivne strategije (meta)kognitivne kontrole učenja (MKK) i DKP. Muški rod učenika, oni s nižim školskim uspjehom te oni koji više koriste strategije DKP i PKP lakše uče uz pomoć DM. Učenici s višim školskim uspjehom i oni većeg zadovoljstva školom, viši na dimenziji Ugodnosti te oni koji više koriste strategije MKK i DKP više koriste DM u nastavi. Stariji učenici te oni koji više koriste strategije DKP i PKP više koriste DM za učenje kod kuće. Za objektivan školski uspjeh kao prvi kriterij sve varijable, osim korištenja DM, pokazale su određeni doprinos te su uspješno objasnile 34% varijance ovog kriterija. Bolji objektivan školski uspjeh pokazuju mlađi i savjesniji učenici, učenice te oni koji više koriste adaptivne strategije MKK, a manje maladaptivne strategije PKP. Veće zadovoljstvo školom kao drugi kriterij pokazuju mlađi učenici, ugodniji i neurotičniji te oni koji više koriste adaptivne strategije MKK. Korištenje DM nije doprinijelo ni objašnjenju ovog kriterija. Postotak objašnjene varijance ovog kriterija je očekivano manji i iznosi 7%. Ključne riječi: objektivan i subjektivan školski uspjeh, sociodemografske osobine učenika, crte ličnosti, strategije učenja, korištenje digitalnih medija u učenju i nastavi
Povezanost akademske prokrastinacije, akademskog lokusa kontrole i osobina ličnosti s akademskim uspjehom
Authors:   Odjel za psihologiju, Hrvatsko katoličko sveučilište, Zagreb, Galić Gabriela , Matešić Krunoslav, ml. ,   Odjel za psihologiju, Hrvatsko katoličko sveučilište, Zagreb
Published: November 2020

Cilj istraživanja bio je ispitati odnos akademske prokrastinacije, akademskog lokusa kontrole, osobina ličnosti te akademskog uspjeha kod studenata. Također se ispitivala povezanost akademske prokrastinacije i osobina ličnosti. Varijable korištene u istraživanju objasnile su 20,1% ukupne varijance akademskog uspjeha. Akademska prokrastinacija nije ostvarila značajnu prediktorsku ulogu u objašnjavanju akademskog uspjeha. Rezultati provedenog istraživanja pokazuju da je veći stupanj odgađanja akademskih obveza povezan s lošijim akademskim uspjehom, ali vrijedi i suprotno, što znači da studenti koji manje odgađaju akademske obveze postižu bolji uspjeh. Osim toga, prema rezultatima značajni prediktori akademskog uspjeha su savjesnost i neuroticizam. Pokazalo se da je akademska prokrastinacija povezana s visokim rezultatima na neuroticizmu, a niskim rezultatima na savjesnosti. Internalni lokus kontrole pokazao se kao značajan prediktor akademskog uspjeha, što bi trebalo značiti da studenti s internalnim lokusom kontrole postižu bolji akademski uspjeh od studenata s eksternalnim lokusom kontrole. Ključne riječi: akademska prokrastinacija, akademski uspjeh, osobine ličnosti, lokus kontrole
CEPTEN SAĞLIK HARCAMASI YAPILMASINI BELİRLEYEN FAKTÖRLER: MİKRO VERİLER İLE TÜRKİYE ÖRNEĞİ
Authors: DOĞAN Esra
Published: November 2020

Sağlık hizmetlerine yönelik cepten harcamalar, hizmet niteliğinden bağımsız olarak yüksek gelir gruplarında ortaya çıkabilecek bir durumken, düşük gelir gruplarında da sosyal güvencenin yokluğuna bağlı olarak zorunlu olarak ortaya çıkabilmektedir. Hizmetin niteliğinden bağımsız olarak ortaya çıkan bu durum sadece fiyat farklılaşması temeline dayanmaktadır. Diğer taraftan sağlık hizmetlerinin niteliğindeki farklılaşmaya bağlı olarak cepten harcama yapılmasının tercih edilmesi halinde ise sağlık hizmetlerine yönelik cepten harcamalar hizmet farklılaşması temeline dayanmaktadır. Bu çalışmanın amacı da sağlık hizmeti için yapılan cepten harcamaların, sağlık hizmetlerindeki fiyat farklılaşması mı yoksa hizmet farklılaşmasına mı bağlı olarak gerçekleştiğini ortaya koymaktır. Bu doğrultuda halihazırda cepten sağlık harcaması yapanların sosyal güvenlik kapsamına dahil olması halinde de cepten harcama yapma olasılığı üzerinde belirleyici olan faktörlerin saptanmasına yönelik lojistik regresyon analizi yapılmıştır. Yapılan analiz sonucu elde edilen bulgular, sosyal güvence kapsamındayken dahi cepten harcama yapılması üzerinde; sosyal güvencenin varlığı, gelir düzeyinin, genel sağlık durumunun, cinsiyet, medeni durum, yaş, öğrenim düzeyi, sağlık kurumu tercih nedeni değişkenlerinin belirleyici olduğu şeklindedir. Bu bulgulardan hareketle de cepten harcamaların sadece fiyat farklılaşmasına değil, hizmet farklılaşmasına bağlı olarak da ortaya çıktığı sonucuna ulaşılmıştır. Ulaşılan bu sonuç ise sağlık hizmetlerinin sosyal güvenlik kapsamındaki sunumunda niteliksel iyileşmelerin gerekliliğini ortaya koymuştur.
KAYNAŞTIRMA ÖĞRENCİLERİNİN OKUMA EĞİTİMİNE YÖNELİK UYGULAMALAR
Authors: ÇARKIT Cafer
Published: November 2020

Kaynaştırma,
özel eğitim ihtiyacı olan öğrencilere ihtiyaç duydukları eğitim hizmetlerinin
sağlanması amacıyla yürütülen faaliyetlerdir. Kaynaştırma öğrencilerine yönelik
gerçekleştirilecek okuma eğitimi onların topluma kazandırılmasında oldukça
önemli görülmektedir. Bu çalışmada kaynaştırma öğrencilerinin okuma eğitimine ilişkin
sınıf ve Türkçe öğretmenlerinin görüşleri ile gerçekleştirmiş oldukları
uygulamalar ele alınmaktadır. Araştırma Gaziantep ve Kayseri merkez ilçelerinde
görev yapan ve kaynaştırma eğitimi veren 5’i sınıf, 5’i Türkçe öğretmeni olmak
üzere toplam 10 öğretmen ile yürütülmüştür. Çalışmada nitel araştırma
yöntemlerinden durum çalışması kullanılmıştır. Araştırma verileri yarı
yapılandırılmış görüşme formuyla toplanmış ve içerik analizi ile çözümlenmiştir.
Öğretmenler bir ihtiyaç olması ve kaynaştırma öğrencilerinin kendilerini
ispatlamalarına olanak vermesi yönüyle yapılan okuma çalışmalarını önemli
görmektedirler. Birebir okuma ve tutor destekli okuma kaynaştırma
öğrencilerinin okuma eğitiminde en sık kullanılan yöntemler olarak
belirlenmiştir. Sınıfların kalabalık olması ile aile desteğinin olmaması ise
öğretmenlerin bu konuda yaşadıkları güçlükler olarak tespit edilmiştir.
STUDENTS ABOUT THE GREAT PATRIOTIC WAR (BASED ON A SURVEY RESULTS OF STUDENTS AT UNIVERSITIES IN MOSCOW AND ASTRAKHAN)
Authors: DIAKOVA Vera V. , KARGOPOLOVA Ekaterina V. , Davydova Uliya A.
Published: November 2020

2020 is marked by the celebration of the 75th anniversary of the Great Victory. This event is significant both for individual citizens, whose families include (or included) veterans of the war and home front, and for the state as a whole, since patriotism is an important factor in ensuring the stable development of the country, the continuity of generations, and the consolidation of the population. That is why the relevance of this topic is beyond doubt.
The Russian Society of Sociologists initiated the next wave of the monitoring project “Modern Russian Students on the Great Patriotic War” (the method of collecting information — online questionnaires on Google Forms, N = 10 065; the results were processed using the Vortex software package), the results of which will not only allow studying the opinions of young people on this topic, but can also be used to analyze the value orientations of young people over the past 15 years and make forecasts. This article describes some of the results of this project, obtained in Moscow and Astrakhan.
Students’ opinions are analyzed according to a number of indicators: memory of the war, sources of knowledge about the war, family relations with the war participants, personal and family involvement in understanding the events of the 1941-1945 war, participation in festive events and their assessment. The characteristic is given to the value attitudes and orientations of students, which emphasize the importance of the memory of the Victory over fascism as a form of upbringing of patriotism and family tradition.
The authors have compared the students’ opinions in universities of the two cities through the prism of “capital — region (province)”, which resulted in the conclusion about greater personal and family involvement in festive events for the Victory Day of the students of Astrakhan.
Прочностные свойства циркониевой керамики, упрочненной оксидом алюминия, с добавлением диоксида кремния
Authors: Дмитриевский А.А. , Жигачева Д.Г. , Жигачев А.О. , Овчинников П.Н.
Published: November 2020

The effect of alumina and silica on strength of zirconia ceramics, stabilized with calcia, was studied. We have established the optimal concentrations of the components in the CaO-ZrO2+Al2O3+SiO2 system; these concentrations correspond to the highest flexural strength of 980±70 MPa. The optimal concentration of alumina is 5 wt.% in absence of silica. In terms of compressive strength the highest values of 2.44±0.15 MPa were obtained when concentration of alumina was 5 wt. % and content of silica was 5 mol. %. Stress-strain diagrams indicate presence of plasticity in the materials containing 4-5 mol. % SiO2 by having a yield plateau
О формуле Леонтьева для параметра Грюнайзена твердых тел
Authors: Сандитов Д.С. , Машанов А.А.
Published: November 2020

Установлено, что формула Леонтьева находится в удовлетворительном согласии с уравнением Грюнайзена. Дается комментарий к выводу данной формулы. Обсуждается кажущееся противоречие в ней. Рассмотрено ее применение к кристаллическим и стеклообразным твердым телам. Показано, что из формулы Леонтьева можно вывести соотношение Беломестных-Теслевой, согласно которому параметр Грюнайзена оказывается однозначной функцией коэффициента Пуассона. Ключевые слова: упругие и тепловые свойства, ангармонизм, уравнение Грюнайзена, скорости акустических волн, формулы Леонтьева и Беломестных-Теслевой, кристаллы, стекла.
Незаполненные электронные состояния и потенциальный барьер в пленках замещенных дифенилфталидов на поверхности высокоупорядоченного пиролитического графита
Authors: Комолов А.С. , Лазнева Э.Ф. , Герасимова Н.Б. , Соболев В.С. , Пшеничнюк С.А. , Асфандиаров Н.Л. , Крайкин В.А. , Handke B.
Published: November 2020

The results of a study of the unoccupied electronic states of ultrathin films of bis-carboxyphenyl-phthalide (DCA-DPP) and bis-methylphenyl-phthalide (DM-DPP) up to 8 nm thick are presented. The studies were carried out by total current spectroscopy (TCS) technique in the energy range from 5 eV to 20 eV above EF during thermal vacuum deposition of these organic films on the surface of highly oriented pyrolytic graphite (HOPG). The energy Evac relative to EF, that is, the electronic work function of the DM-DPP films, at a film thickness of 5–8 nm was 4.3 ± 0.1 eV. The electronic work function of the DCA-DPP films was 3.7 ± 0.1 eV. The structure of the maxima of the unoccupied electronic states of DCA-DPP films and DM-DPP films in the studied energy range is determined. The properties determined of DCA-DPP and DM-DPP films are compared with the properties of films of unsubstituted diphenylphthalide (DPP). According to our analysis, –CH3 substitution of the DPP molecule practically did not affect the height of the potential barrier between the film and the HOPG surface, and –COOH substitution of the DPP molecule led to an increase in the height of the potential barrier between the film and the HOPG substrate surface by 0.5–0.6 eV. Substitution of DPP molecules with –COOH functional groups which represents formation of DCA-DPP molecules led to a shift of two peaks of the experimental total current spectra located at energies in the range from 5 eV to 8 eV above EF, by about 1 eV towards lower electron energies.
Упругие свойства графеноподобных соединений: модели Китинга и Харрисона
Authors: Давыдов С.Ю. , Посредник О.В.
Published: November 2020

Для 9 соединений IV-IV и 13 соединений III-V с использованием моделей Китинга и Харрисона получены оценки упругих постоянных третьего порядка, зависимости упругих постоянных второго порядка от давления, параметров Клейнмана и Грюнайзена и коэффициентов теплового расширения. Анализируются зависимость результатов от ионности связей по Филлипсу и расстояния между ближайшими соседями. Ключевые слова: упругие постоянные, параметры Клейнмана и Грюнайзена, коэффициент теплового расширения.
Spatial determinants of foreign direct investment in Iraq - an analytical study for the period 1995-2018
Authors: Maher Asaad Hamdi
Published: November 2020

The topic of attracting foreign investment in general and foreign direct investment in particular has gained special importance, as it is one of the main pillars on which countries depend to finance and develop their development programs in various economic sectors. Also, foreign direct investment is an effective means of transferring modern technology and its creation and development. Modern methods and methods of production contribute to high rates of economic growth.

Therefore, the determinants of foreign direct investment in Iraq have been chosen as a subject for research, to identify the nature of FDI flows and to measure and analyze the relationship between a number of economic variables and between foreign direct investment in Iraq for the period 1995 - 2018, as we have found a positive and statistically significant relationship between some economic variables And between foreign direct investment, and the presence of an inverse and statistically significant relationship between a number of other economic variables and foreign direct investment.
Multidimensional Machine Learning Personalized Prognostic Model in an Early Invasive Breast Cancer Population-Based Cohort in China: Algorithm Validation Study
Authors: Zhong Xiaorong , Luo Ting , Deng Ling , Liu Pei , Hu Kejia , Lu Donghao , Zheng Dan , Luo Chuanxu , Xie Yuxin , Li Jiayuan , He Ping , Pu Tianjie , Ye Feng , Bu Hong , Fu Bo , Zheng Hong
Published: November 2020

Background

Current online prognostic prediction models for breast cancer, such as Adjuvant! Online and PREDICT, are based on specific populations. They have been well validated and widely used in the United States and Western Europe; however, several validation attempts in non-European countries have revealed suboptimal predictions.

Objective

We aimed to develop an advanced breast cancer prognosis model for disease progression, cancer-specific mortality, and all-cause mortality by integrating tumor, demographic, and treatment characteristics from a large breast cancer cohort in China.

Methods

This study was approved by the Clinical Test and Biomedical Ethics Committee of West China Hospital, Sichuan University on May 17, 2012. Data collection for this project was started in May 2017 and ended in March 2019. Data on 5293 women diagnosed with stage I to III invasive breast cancer between 2000 and 2013 were collected. Disease progression, cancer-specific mortality, all-cause mortality, and the likelihood of disease progression or death within a 5-year period were predicted. Extreme gradient boosting was used to develop the prediction model. Model performance was assessed by calculating the area under the receiver operating characteristic curve (AUROC), and the model was calibrated and compared with PREDICT.

Results

The training, test, and validation sets comprised 3276 (499 progressions, 202 breast cancer-specific deaths, and 261 all-cause deaths within 5-year follow-up), 1405 (211 progressions, 94 breast cancer-specific deaths, and 129 all-cause deaths), and 612 (109 progressions, 33 breast cancer-specific deaths, and 37 all-cause deaths) women, respectively. The AUROC values for disease progression, cancer-specific mortality, and all-cause mortality were 0.76, 0.88, and 0.82 for training set; 0.79, 0.80, and 0.83 for the test set; and 0.79, 0.84, and 0.88 for the validation set, respectively. Calibration analysis demonstrated good agreement between predicted and observed events within 5 years. Comparable AUROC and calibration results were confirmed in different age, residence status, and receptor status subgroups. Compared with PREDICT, our model showed similar AUROC and improved calibration values.

Conclusions

Our prognostic model exhibits high discrimination and good calibration. It may facilitate prognosis prediction and clinical decision making for patients with breast cancer in China.
analytica virtual – новый формат и новые рекорды
Authors: Алёшин А.Н.
Published: November 2020

В этом году из-за ограничений, возникших в связи с пандемией коронавируса, традиционная выставка analytica прошла в онлайн-формате с 19 по 23 октября 2020 года. Для проведения выставки была создана специальная виртуальная платформа, а само мероприятие получило название analytica virtual.
System Methods of Research of Small Arms Designs
Authors: Alekseev S. A.
Published: November 2020

При проектировании сложных технических систем, к которым относятся образцы вооружения, в последнее время особое значение приобрел новый методологический подход, называемый системным. Под методологией обычно понимается совокупность приемов, а также математический аппарат научных исследований, которые имеют определенную общность и сохраняют свое практическое значение в течение всего процесса проектных работ. Основными приемами системной методологии являются: описание системы в виде иерархически упорядоченной структуры путем построения морфологического и функционального дерева, разделение объектов на систему и окружающую среду, декомпозиция функций и структуры системы. При исследовании систем в зависимости от целей применяются макроскопический либо микроскопический методы.На примерах из области стрелкового оружия проиллюстрированы основные ключевые понятия и основные положения системного анализа. Рассмотрены методы и подходы, применяемые на различных стадиях исследования и проектирования систем вооружения. Автоматическое оружие представлено в виде многоуровневой структуры, состоящей из подсистем, каждая из которых имеет свое функциональное назначение. Приведены примеры построения морфологического дерева и дерева функций.Показано, что на ранних стадиях проектирования объекта эффективен макроскопический подход в сочетании с функционально-структурным методом исследования. При таком подходе не определены однозначно принцип действия, состав и структура объекта, а заданы только функции, которые он должен выполнять. Это дает возможность исследователю находить новые технические решения. На стадии технического проектирования, когда определены принцип действия и структура объекта, применяется микроскопический подход и структурно-функциональный анализ с целью повышения качества объекта, например, при модернизации образцов вооружения.
HPV co-testing as cervical screening test, Experience of Alweiya early detection cervical clinic: one-year Analysis
Authors: Al-Jobawi Zainab J , Ali Besmah M. , Al-Niyazee Asan A , Ibraheem Mustafa H
Published: November 2020

Objectives: The high-risk Human papilloma virus test with conventional cytology (HPVco-test) was firstly introduced in our institute at May 2019 so we aimed to estimate the prevalence of abnormal cytology and positive high-risk human papillomavirus test results in a screening woman and to assess the accuracy between cytology and Human papilloma virus testing to evaluate the feasibility of integrating the latter as a primary test in the national cervical cancer screening program.

Methods: A prospective study for women attending to early detection cervical clinic, during the period from May 2019 to May 2020. Patients who were sexually active were included in the study. Samples for conventional cytology and HPV by using real-time polymerase chain reaction technique for high risk types were taken concurrently. The prevalence of positive screening results and the difference in accuracy between two testing were estimated by McNemarâ€™s Ï‡2 test.

Result: A total of 388 women were included in the study. The prevalence of positive test for hr-HPV was 2.1%(8) while the prevalence of abnormal cytology test was 19.1%(74), Concerning discordant pairs, 0.8%(3) of women had normal cytology with a positive hr-HPV test result and 17.8%(69) of women had abnormal cytology with a negative  hr-HPV test result. A total of 311 (80.1%) women had normal cytology and negative hr-HPV test results. The proportion of women with abnormal cytology and positive hr-HPV test results was 1.3% (5 women). the difference in accuracy between the two results was statistically significant (<0.0001). The prevalence of positive hr-HPV test decreased with increasing age, whereas the prevalence of abnormal cytology showed a bimodal age pattern.

Conclusion: The prevalence of abnormal cytology was high to that of hr-HPV testing, which could not allow for the implementation of hr-HPV as a primary test in the national screening program in Iraq.
AN ANALYSIS OF FOCUSED METALINGUISTIC WRITTEN FEEDBACK: How would learners react?
Authors: Rizqiyyah Rizqiyyah , Prianty Tanty
Published: November 2020

Learners of higher education are encouraged to write a scholarly publication in that it helps corroborate them as professionals in their fields of study. Practices in academic writing are thus indispensable to do to achieve a higher level of competency. This study explores learners’ reactions towards focused metalinguistic written feedbacks provided by a lecturer. The lecturer used electronic mail to provide constructive feedback to her students. This mixed-method study involved 22 post-graduate students from an Indonesian university. In analyzing the qualitative data, the researchers employed Miles and Huberman’s qualitative data analysis approach. Meanwhile, the quantitative data, namely the basic analysis of focused metalinguistic written feedbacks were analyzed by employing Cumming’s writing approach. The findings reveal that: (1) learners revised and expanded their draft after getting back their paper; (2) lecturer’s feedbacks through email have reportedly motivated learners because such the feedbacks did not lead learners perplexity compared to the handwritten feedbacks; (3) the majority of participants used revising and responding, consulting a dictionary/grammar book, and referring to the previous composition as the ways to handle lecturer’s input.
Ciclo vital y chamanismo entre los indios chocó. Visión de mitad de siglo
Authors: Pineda Giraldo Roberto , Gutiérrez de Pineda Virginia
Published: November 2020

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Datos paleopatológicos y culturales sobre un cráneo arqueológico de Belalcázar, Cauca (Tierradentro)
Authors: Cárdenas Arroyo Felipe , Rondón Luis Guillermo
Published: November 2020

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Estatuaria del Macizo Colombiano de María Lucía Sotomayor y María Victoria Uribe
Authors: Lleras Pérez Roberto
Published: November 2020

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Improving Students' Motivation and Focus Through the Gamification in the Computer Science Peer Instruction Methodology (CSPI)
Authors: Caceffo Ricardo , Azevedo Rodolfo
Published: November 2020

The Peer Instruction (PI) is an active learning, student-centered approach designed to engage students through the administration of conceptual questions. On its turn, the CSPI is an adaptation of the PI to the computer science area, mainly Introductory Programming (CS1) courses. In this work, we present the initial assessment of the gamification adoption into the CSPI. Two CSPI/CS1 courses were administered, one without gamification (control experiment) and one with it. We identified that, although participants originally didn’t expect that gamification would affect their experience, results suggest that gamification positively impacts participants' motivation and focus. Future work involves the analysis of collaboration and interaction variables through learning analytics tools.
MarineVerse Enables More People to Sail!
Authors: Tizuka Michelle , Dziemidowicz Greg
Published: November 2020

MarineVerse wants to promote and share the sport of sailing with the world by providing sailing education,growing as a sailor, socializing, and having entertainment using virtual reality technology. Current VR sailingapplications are designed for Valve Index, HTC Vive, Oculus Rift, and Oculus Quest, and flagship products areMarineVerse Cup and VR Regatta.
Prenatal diagnosis of criss-cross heart with congenitally corrected transposition of the great arteries and aortic coarctation - case report
Authors: Murlewska Julia , Kućmierz Joanna , Witkowski Sławomir , Żalińska Agnieszka , Respondek-Liberska Maria
Published: November 2020

This paper presents an extremely rare and difficult case report of
criss-cross heart (CCH) with a combination of cc-TGA and aortic
coarctation of the fetal heart at 33 weeks of gestation. Despite very
complicated heart anatomy, the proper perinatal care and early cardiac
surgery allowed us to observe normal development of the child without
any problems during his first six and ten months of postnatal life. The
impossibility to: image proper four-chamber view, obtain parallel
tricuspid and mitral valve, visualize symmetrical valve motion and
laminar flow from the atrium to the ventricle might be the first clues
to diagnose CCH.
Analisis Butir Soal Ujian Semester Ganjil Kimia Kelas X SMA Negeri 1 Perbaungan
Authors: Purba Ria Atika , Susanti Nora , Rosna Rosna
Published: November 2020

The purpose of this study is to find out the quality of the odd chemistry semester exam questions of class X IPA 1 Perbaungan 2017/2018 school year based on qualitative analysis (material, construction, and language), analysis of cognitive level distribution, and quantitative analysis (validity, reliability, power difference, level of difficulty, and effectiveness of deception) using the ANATES V4 program. This study uses a type of quantitative research with descriptive methods. The results of this study are that the content validity in the material is in a very high category, in the construction aspect in the low category and the language aspect in the category is very high. Results based on cognitive domain level distribution are not in accordance with domain level proportions. The results of the study are based on quantitative analysis which is based on validity is 55% valid, and 45% is invalid. Based on reliability is 0.76. Based on the difference in power is good and based on effectiveness the deception is effective.
IMPLEMENTASI MODEL PEMBELAJARAN PROBLEM BASED LEARNING DENGAN PENDEKATAN SAINTIFIK TERHADAP HASIL BELAJAR LAJU REAKSI SISWA
Authors: Marpaung Aisyatur Radhwa , Sutiani Ani
Published: November 2020

One of the subject matter of Chemistry High School which has quite extensive studies and full of concepts is Reaction Rate. The subject matter will be more precisely taught through Problem Based Learning (PBL) with scientific approach that designed with surrounding environment. This study aims to determine difference between increasing learning outcomes learned through PBL with scientific approach and increasing learning outcomes learned through Direct Instruction (DI) with scientific approach on Reaction Rate. The population was all students of XI MIA MAN. The sampling technique in this study was purposive sampling. The results showed an increase in student learning outcomes in experimental class by 84% and in control class by 79%. Based on test of the real difference with the statistical technique t at the level of significance α = 0.05 on the results of this study it can be concluded that increase in student learning outcomes through the PBL with scientific approach is higher than increase in learning outcomes taught through the DI with scientific approach to Reaction rate.
PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING TERHADAP KPS SISWA DAN HASIL BELAJAR PADA MATERI ASAM BASA
Authors: Malau Rialdi , Juniar Anna
Published: November 2020

This study aims to: (1) To know the student Learning Outcomes that learned by Guided Inquiry were higher than Conventional model, (2) To know the student KPS  improvment that learned by Guided Inquiry were higher than the conventional model, (3) To know the correlation between learning outcomes and KPS of students that learned by Guided Inquiry model . The population of this study is all students of class XI IPA  SMA Budasatria. The sample selection is by total sampling namely XI IPA 1 and XI IPA 2, class XI IPA 1 with the Guided Inquiry learning. The instrument used a learning outcome test in the form of 20 valid multiple choice, the KPS test instrument in the form of an essay test. From t-test with a significance level of 0.05 worth 1.6749 is 9.2 on learning outcomes and 17 on KPS. Then from the Product Moment Correlation test with a significance level of 0.05, the rtable value is 0.37, the rcount is 0.81, so there is correlation between student learning outcomes and KPS. The contribution of learning outcomes to the increase in KPS by 65%.