bluuebunny/crossref_metadata_2025 huggingface dataset:
Anthropomorphism Unveiled
Authors: Hathaway Eden
Published: April 2024

This essay explores Wes Anderson's Isle of Dogs through the lens of anthropomorphism and multispecies theory, examining how the film captures the complexities of human-animal relationships and the interconnectedness of all beings. Anderson's distinctive filmmaking style, characterized by vibrant visuals and intricate narratives, serves as a backdrop for the exploration of themes such as empathy, collaboration, and the blurring of boundaries between human and non-human worlds. Drawing upon Donna Haraway's ideas in When Species Meet and academic film reviews, the essay analyzes key scenes and characters to uncover the profound insights offered by Isle of Dogs regarding the nature of interspecies communication and the transformative power of companionship. Ultimately, the film challenges viewers to rethink their perspectives on the world around them and embrace a more inclusive understanding of multispecies interactions.
Vacunación óptima para un modelo SIRS
Authors: Hernández Matias Ezequiel
Published: April 2024

En este trabajo presentamos un modelo SIRS para la dinámica de una enfermedad infecciosa sobre una población de individuos, donde se contempla el accionar de un programa de vacunación. Se demuestra que el sistema de ecuaciones diferenciales que describe la dinámica de la enfermedad tiene solución. Es formulado un problema de optimización, relacionado con minimizar el número de individuos susceptibles e infectados, maximizar el número de individuos removidos, y minimizar también la proporción de personas vacunadas. Para aproximar el ?optimo del problema planteado, optamos por discretizar y luego optimizar. Por último se presentará un resultado numérico y la conclusión del trabajo.
Estudio de particularidades del aprendizaje de la geometría tridimensional
Authors: Götte Marcela , Mántica Ana María
Published: April 2024

Este trabajo es parte de una investigación más amplia cuyo objetivo es detectar y analizardificultades y errores cometidos por futuros profesores de matemática en la realización dedemostraciones geométricas tridimensionales y categorizar los errores detectados.Se presentan algunas dificultades que tienen los alumnos, de la cátedra Geometría Euclídea Espacial del Profesorado en Matemática de la Facultad de Humanidades y Ciencias, en la resolución de problemas que involucran los conceptos de perpendicularidad y paralelismo. Estos conceptos son complejos en su aprendizaje, más aún, como se muestra en este estudio, en la geometría del espacio, coincidiendo con lo señalado por Volkert (2008) que la geometría sólida presenta mayor dificultad que la plana.
Análisis de un problema de optimización desde el enfoque ontosemiótico
Authors: Baccelli Sandra Graciela , Anchorena Sergio , Figueroa Stella Maris , Prieto Gloria
Published: April 2024

El objetivo de este trabajo es realizar un análisis exploratorio descriptivo de lasdificultades de los alumnos para resolver problemas de optimización a fin de mejorar lasestrategias de enseñanza de este tema. El análisis se basa en el desempeño de un grupo de 38 estudiantes de Ingeniería de la UNMDP. Se utiliza como instrumento de recolección de datos un protocolo diseñado para operacionalizar los conceptos del Enfoque Ontosemiótico de la Instrucción y la Cognición Matemática que pretende captar la configuración epistémica y a las configuraciones cognitivas asociadas al problema. Losalumnos que resuelven satisfactoriamente este problema representan un bajo porcentaje, los resultados del análisis muestran que las dificultades detectadas en las resoluciones se encuentran principalmente en algunos de los procedimientos empleados, se identifican aquellos procedimientos críticos en los que se puede intervenir para lograr un mejor desempeño a la hora de resolver este tipo de problemas.
Objetos matemáticos y registros semióticos para un aprendizaje significativo
Authors: Dal Bianco Nydia , Prieto Martinez Fabio
Published: April 2024

El presente trabajo se circunscribe a una propuesta de enseñanza implementada en la Facultad de Ciencias Exactas y Naturales de la Universidad Nacional de La Pampa, con alumnos de primer año de Química y Biología que durante el ciclo académico 2010 cursaban Matemática. Utilizando la plataforma Moodle y los recursos que provee el software GeoGebra se diseñó e implementó una estrategia didáctica para el desarrollo del tema Secciones Cónicas, correspondiente a una de las unidades del programa de esta asignatura. El proceso de contextualizar objetos matemáticos en situaciones de enseñanza – aprendizaje, no sólo se consolida con la automatización de ciertos tratamientos o la comprensión de nociones, sino que implica una coordinación de registros de representación. Un sujeto comprende el significado de un determinado concepto si,por ejemplo es capaz de reconocer sus propiedades y representaciones características, establecer relaciones con otros objetos y aplicarlo en diversas situaciones problemáticas. Los docentes que participamos en esta propuesta consideramos que a futuro realizaremos acciones de características similares en otros contenidos, reflexionando sobre nuestra práctica docente y con el objeto de favorecer el aprendizaje de esta disciplina con alumnos de carreras no matemáticas.
Robustez Asintótica de la Estadística de Hotelling
Authors: Gneri Mario Antonio , Barbosa Emanuel Pimentel
Published: April 2024

Es sabido que, bajo la hipótesis de normalidad, la distribución asintótica de la estadística T 2 de Hotelling es uma chi-quadrado. En este trabajo damos una demostración de que la hipótesis de normalidad puede ser suprimida, permaneciendo el resultado válido bajo condiciones bastante generales (finitud de momentos de orden 2 y matriz de covariancia definida positiva). Esta afirmación más general es también mencionada en la literatura, pero nos parece necesaria una demostración rigurosa de la misma.
Experiencia Innovadora de utilización de las tics en la formación de docentes
Authors: Gil Lucía , Calvo Inés
Published: April 2024

En este trabajo se presenta la implementación de un curso semi-presencial de la incorporación de las nuevas Tecnologías en enseñanza de la Matemática, impartido por docentes integrantes de un proyecto de Investigación Educativa de la Facultad de Ciencias Exactas, Física y Naturales de la Universidad Nacional de San Juan, a docentes del nivel secundario. La experiencia comienza mediante una sección inicial presencial, un periodo de dos semanas de enseñanza virtual, otro encuentro presencial y nuevamente dos semanas de enseñanza virtual. Al finalizar el curso una sesión de ajuste y evaluación denominada puesta en común con el fin de analizar y discutir la metodología y resultados de las actividades propuestas. Respondiendo a los objetivos, las nuevas tecnologías utilizadas para la implementación del curso son aquellas que a su vez, los docentes deben poner en práctica en el proceso de enseñanza aprendizaje, dando de esta manera importancia al efecto multiplicativo de la experiencia, tendiendo a acortar la brecha existente entre el alumno y el docente.
Análisis Etnomatemático de Pesas y Medidas en la Catamarca Colonial (1683-1828)
Authors: Juarez Gustavo Adolfo , Navarro Santa Ana Luis , Navarro Silvia Inés
Published: April 2024

Usufructuando el espacio de ilustración, diálogo y debate que nos ofrece éste encuentro científico, presentamos el resultado de un trabajo de investigación interdisciplinario contextualizado en estudios etnomatemáticos. Rescatando la esencia de las definiciones de matemática, de cultura y etno, tomamos como premisa para conceptualizar nuestra óptica y sustento científico, al “conjunto de conocimientos matemáticos de una comunidad, relacionados con su cosmovisión e historia, disponiendo de un nexo entre la matemática y sus prácticas”. El objetivo fundamental de este trabajo es demostrar como los habitantes de la Catamarca Colonial (1683-1828), matematizaron su existencia; es decir, la manera como efectivizaron sus cuentas, como midieron, relacionaron y clasificaron, e incluso como infirieron en su cotidiano accionar en un contexto circundante y circunstancial. Aplicando el método histórico inquisitivo-crítico y el analógico axiomático, estudiaremos las unidades o sistemas de medidas utilizados local y/o regionalmente de las magnitudes capacidad, peso y volumen, en el marco tempo-espacial determinado y las equivalencias correspondientes a los tiempos presentes. Las fuentes primarias que sustentan el corpus de la investigación, desde la perspectiva histórica, serán las Actas Capitulares, los Protocolos de Escribanos y los Libros de Autógrafos, Leyes y Decretos. Se utilizará también como soporte una bibliografía específica sobre la temática específica desde la Historia de las Matemáticas y la Etnomatemática.
Relaciones entre las actividades de los profesores en el aula y la subestimación del alumno
Authors: Sureda Figueroa , Otero M. Rita , Elichiribehety Ines
Published: April 2024

Este trabajo aborda la práctica docente desde marcos cognitivos y didácticos como la Teoría de los Campos Conceptuales (Vergnaud, 1990), la Teoría del Aprendizaje Significativo (Ausubel, 1963) y la Teoría Antropológica de lo Didáctico (Chevallard, 1999). Dichos referenciales se utilizan de manera complementaria para: identificar algunos teoremas en acto pertenecientes a los esquemas de los profesores, relacionar dichos teoremas con las organizaciones matemáticas y didácticas puestas en juego y discutir si tales acciones son apropiadas para propiciar aprendizaje significativo.
Un análisis histórico-epistemológico de la topología y su vinculación con el saber enseñado en la formación de profesores de matemática
Authors: Bastán Marta , Cuenya Héctor , Fioritti Gema
Published: April 2024

Este trabajo forma parte de la tesis de maestría en Didáctica de la Matemática: La Transposición Didáctica de la Topología en la Formación de Profesores de Matemática. Incidencia de los modelos epistemológicos y docentes.Desde el marco teórico de este proyecto El Programa Epistemológico iniciado por Broussea(1986), se asigna un rol fundamental al estudio del saber matemático, no sólo como un saber en sí mismo sino anlizando el tipo de problemas que le dieron origen, , las técnicas matemáticas (entendidas éstas como maneras de hacer, no como algoritmos) que surgen en ese contexto y los elementos tecnológico-teóricos que se utilizan.A partir del estudio histórico-epistemológico pudo verse que los problemas que le dieron origen se sitúan en dos contextos matemáticos diferentes: el Geométrico y el del Análisis Matemático y que en cada uno de ellos se da respuesta a determinado tipo de problemas, que se resuelven con técnicas diferentes y que utilizan tecnologías diferentes aunque mantienen en común ciertos elementos tecnológico-teóricos.Teniendo como base este análisis se realiza un estudio de la organización matemática enseñada, respecto de lo topológico en la formación de profesores de matemática, para dar cuenta de las restricciones que sufre el saber hasta tomar las características particulares que presenta en ese ámbito y las razones que determinan esas restricciones.
La Fundamentación de la Matemática
Authors: Zuppa Carlos
Published: April 2024

El objeto del presente trabajo es presentar un muy pequeño pantallazo -por razones de espacio y también por las dificultades técnicas inherentes al tema- de la historia de la fundamentación de la matemática en los dos siglos precedentes y las desventuras del reduccionismo formal absoluto después de los trabajos de Gódel y Turing. Trataremos de mostrar, con las limitaciones inherentes a la simplicidad que se pretende para este trabajo, que es precisamente en la fundamentación donde la matemática también conoce de las angustias epistemológicas, de perturbaciones del espíritu e incertezas, y realiza elecciones metamatemáticas.
Una métrica simple y curiosa
Authors: Cuenya Héctor H.
Published: April 2024

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Ecuaciones Funcionales Involucrando Funciones Trigonométricas y Exponenciales
Authors: Kurepa Alexandra
Published: April 2024

Este artículo puede servir como una introducción al área de ecuaciones funcionales dando los ejemplos mas "naturales", aquellos involucrando funciónes exponenciales y trigonométricas familiares para los estudiantes. Presentamos aquí una prueba alternativa del hecho de que el sistema de ecuaciones funcionales (1.1) y (1.2) en el conjunto de funcionescontinuas tiene las soluciones dadas por (1.3). La prueba es elemental, pero matemáticamente rigurosa, y por lo tanto, particularmente apropiada para estudiantes (secundarios) avanzados
Enseñando una matemática más novedosa y divertida. Parte II: Sucesiones Numéricas y logaritmo
Authors: Cosenza Nora , Gurruchaga Norma , Vignoli María José
Published: April 2024

La finalidad de este trabajo (continuación de la Parte I) es despertar mayor interés en el aprendizaje de la Matemática a través del estudio de situaciones curiosas y novedosas.
Simbolización de las Operaciones Aditivas
Authors: Ochoa Rodríguez Yon Jairo
Published: April 2024

El presente artículo corresponde a una revisión teórica sobre la construcción del lenguaje simbólico, en las operaciones aditivas de grado primero, para llegar a una reflexión sobre la práctica docente en el proceso pedagógico de la enseñanza de la adición. En su desarrollo, primero se desglosa el asidero teórico, donde se trata la construcción del lenguaje simbólico y la enseñanza de las operaciones aditivas. Posteriormente se alude a la metodología utilizada para la realización del artículo y finalmente se precisan algunas consideraciones finales.
El Principio de Dirichlet (o una excusa para pensar matemática)
Authors: Sabia Juan
Published: April 2024

Este trabajo se basa en dos charlas de divulgacion que di en distintos ambitos.El objetivo de una era tratar de describir mediante un ejemplo sencillo la tarea que realiza un matematico cuando investiga. El de la otra era plantear una posible situacion de clase donde el estudiante fuese \descubriendo" la teora a partir de la resolucion de problemas, basandome en (mis escasos conocimientos de) la teora de situaciones didacticas de G. Brousseau (ver [2]). Quiero subrayar que creo que los dos acercamientos son en el fondo el mismo: los matematicos desarrollan herramientas para resolver problemas y es as como generan (y adquieren) nuevos conocimientos.
Fermat Wiles
Authors: Macías Roberto A.
Published: April 2024

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Una mesa inestable
Authors: Alvarez Hugo
Published: April 2024

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LOS NUDOS, UNA DIVERTIDA FORMA DE HACER MATEMÁTICA
Authors: Gutierrez Gerson
Published: April 2024

Los nudos son un apasionante tema dentro de la investigación matemática, y más precisamente dentro del área de la Topología. Siendo los nudos algo tan cercano a nuestro día a día, resulta ser un tema curioso e interesante. En este artículo se muestran algunos tópicos interesantes y divertidos de la teoría de nudos y que tranquilamente pueden llegar a ser un tema a estudiar en una clase de secundario.
Influencia de las creencias de los estudiantes en la resolución de problemas en Educación Matemática
Authors: Fajardo Valencia Arnulfo , Benítez Mojica David
Published: April 2024

Este artículo tiene como objetivo contribuir al conocimiento de las creencias que tienen los estudiantes de educación secundaria sobre las matemáticas. El análisis se ha  enfocado en dar respuesta a las siguientes preguntas: ¿Cuál es el concepto de creencia en el marco de la educación matemática?; ¿Cuáles son las creencias más comunes que tienen los estudiantes de secundaria sobre la resolución de problemas?; ¿Cómo inciden algunas creencias de los estudiantes en la resolución de problemas de matemáticas? Identificamos a partir de la literatura; algunas creencias personales e idiosincráticas que pueden incidir en la forma cómo los estudiantes reaccionan frente al aprendizaje de las matemáticas y determinan la manera como abordan la solución de un problema. Concluimos que los maestros deben generar estrategias que permitan identificar las creencias que tienen los estudiantes sobre las matemáticas, reforzar las que inciden positivamente y transformar  las que sean necesarias para favorecer el análisis y la resolución de problemas
Interpretación de gráficos: el uso de GeoGebra
Authors: Álvarez Marisa , Murúa Rodolfo
Published: April 2024

Son bien conocidos los problemas donde los alumnos y las alumnas tienen que interpretar y “leer” información de un gráfico de una función (o de una relación entre dos variables) dada una situación en contexto extramatemático. Aquí suelen incluirse preguntas para hallar el correspondiente de cierto valor de abscisa (u ordenada), donde a veces la información puede deducirse de forma exacta y otras aproximada. También se pueden analizar variaciones o cuestiones que tengan que ver con el crecimiento o decrecimiento de la función. Ahora bien, ¿qué ocurre si el gráfico viene dado en GeoGebra? Los procedimientos (o las técnicas) para deducir información de él, ¿son las mismas que al trabajar con lápiz y papel? En este artículo anticiparemos distintos tipos de procedimientos que podrían implementar las y los estudiantes. Algunos de ellos están más cercanos al trabajo realizado en lápiz y papel y otros, en nuestra opinión, son sumamente novedosos. Por otro lado, nos podemos preguntar cuáles son los aportes, en cuanto a conocimientos matemáticos, que brinda el programa al trabajar con gráficos “dinámicos”. Cabe aclarar que cualquier potencialidad que tenga el software no se puede desligar de la intencionalidad docente.
Extensiones de los teoremas del valor medio del análisis de una variable
Authors: Pérez Teruel Ginés R.
Published: April 2024

En este trabajo los teoremas del valor medio de Lagrange y Cauchy para funciones reales de variable real son extendidos, incluyendo el caso de la función compuesta. Para ello se sigue un razonamiento inductivo, partiendo de la exploración de casos particulares hasta llegar a una expresión general, procediendo por tanto de lo particular a lo general. El contenido del trabajo puede ser de utilidad para docentes de Matemática como material complementario y de ampliación en sus clases.
The Impact of Cryptocurrency Investor Risk Perception and Awareness on the Current Uses and Future Projections of Cryptocurrencies: A Research on Istanbul Provincial Health Directorate Employees
Authors: Özyeşil Mustafa , Tembelo Havane
Published: April 2024

This study investigates cryptocurrency knowledge, risk perception, and investment strategies among İstanbul Provincial Health Directorate employees. Analyzing data from 399 participants using the Cryptocurrency investment Trust Scale, which is developed by Ozyesil and Tembelo (2023), results indicate limited cryptocurrency awareness, moderate risk perception, and conservative investment tendencies. While most participants have heard of cryptocurrency, their understanding remains shalloyv, perceiving it as high-risk and favoring traditional financial instruments. The study emphasizes the necessity of educational initiatives and regulatory frameworks to facilitate safe and compliant cryptocurrency usage within the healthcare sector.
Yıllık Raporların Metin Analizi İle Değerlendirilmesi: BİST100 Endeksinde Bir Uygulama
Authors: Çerez Sedat , Merter Abdullah Kürşat , Balcıoğlu Yavuz Selim , Özer Gökhan
Published: April 2024

Bu çalışmada, Borsa İstanbul (BIST) 100 endeksindeki 60 finansal olmayan işletmenin faaliyet raporları incelenerek, raporların içeriğindeki konuların ve duygu tonunun analizi gerçekleştirilmiştir. Gizli Dirichlet Ayırımı yöntemiyle faaliyet raporları içerisinde dört temel konu üzerinde ayrışma sağlandığı ve raporların içerisinde yer alan açıklamaların yaklaşık %87'sinin olumlu, %13'ünün ise olumsuz bir duygu sergilediği tespit edilmekte ve bu da raporlarda genel olarak iyimser bir görünüm içerisinde olduğunu göstermektedir. Bu araştırma, kurumsal raporlardan anlamlı iç görüler elde etmek için bir araç olarak metin analizinin potansiyelinin altını çizmekte ve kurumsal performans ve stratejiyi anlamak için yeni bir yaklaşım sunmaktadır.
Türk Mevduat Bankalarının Finansal Performanslarının CAMELS Analizi Yöntemi Kullanılarak Analizi
Authors: Tuner Emrah
Published: April 2024

Bu çalışmada Türk bankacılık sektöründe faaliyet göstermekte olan, aktif büyüklüğü en yüksek 18 adet mevduat bankasının, CAMELS yöntemi kullanılarak 2010 - 2022 yılları arasındaki performansları incelenmiştir. CA¬MELS yöntemi kapsamında, bankaların performanslarında belirleyici olduğu düşünülen 26 adet farklı finansal oran kullanılmıştır. Yapılan analiz sürecinde bankalar CAMELS analiz yönteminin bileşenleri olan sermaye yeterliliği, aktif kalitesi, yönetim kabiliyeti, karlılık, likidite ve piyasa risklerine duyarlılık açısından incelenmiştir. Analiz sonucunda 2010-2022 yılları arasında gerçekleşen bileşik CAMELS puanına göre en yüksek performansa sahip banka Türkiye Garanti Bankası A.Ş., en düşük performansa sahip banka ise Alternatif bank A.Ş. olarak tespit edilmiştir.
Mechanisms of Mitochondrial Influence on Tumor Radioresistivity
Authors:   Institute of Biophysics of the Future, Moscow Region, Dolgoprudny, Russia, Rozenberg J.M. , Maximov V.V. ,   Institute of Biophysics of the Future, Moscow Region, Dolgoprudny, Russia, Kuzmin D.V. ,   Institute of Biophysics of the Future, Moscow Region, Dolgoprudny, Russia, Leonov S.V. ,   Institute of Biophysics of the Future, Moscow Region, Dolgoprudny, Russia
Published: April 2024

Radiotherapy remains one of the main methods of cancer treatment. At the same time, the formation of radioresistance (RR)of cancer cells to ionizing radiation leads to a loss of therapy effectiveness. The toxicity of radiotherapy is determined by mitochondria, and the use of mitochondria or their components in combination with chemo-radio and immunotherapy can increase the effectiveness of treatment. In this review, we have reviewed new, experimental methods for using mitochondria in cancer therapy. Literature data indicate that although the physiological transport of mitochondria promotes carcinogenesis and resistance to chemotherapy, transplantation of exogenous mitochondria, on the contrary, induces radiosensitivity and inhibits tumor growth in mouse models of cancer. Therefore, inhibition of endogenous transfer of cancer mitochondria or the development of methods for the delivery of exogenous mitochondria is a promising area for the development of anti-cancer drugs.
Development of the Legal Framework in the Field of Radiation Safety
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Samoylov A.S. , Kochetkov O.A. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Klochkov V.N. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Barchukov V.G. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Shinkarev S.M. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Published: April 2024

Purpose: To justify the main areas of Russian legacy framework in the field of radiation safety assurance as a basis for improvement of the current standards and regulations. Material and methods: The article analyses international documents and Russian federal laws regulating different aspects of human safety and highlights the most important approaches and procedures of safety assurance proven in practice. Results: The necessity of developing new federal law “On Radiation Safety in Russian Federation” is substantiated. The article shows that internationally recognized principles of radiation safety assurance should be applied in Russia: those are the preservation principle, the responsibility principle, the continuous control principle and, in particular, the permission principle. The last principle means that what is not permitted is forbidden when it comes to handling ionizing radiation sources. The article describes the main provisions and elements of new law and details some considerations that need to be articulated and enhanced in new federal law based on positive experience of their implementation in the current federal laws on different safety aspects. Conclusion: New federal Law “On Radiation Safety in Russian Federation” should incorporate all positive experience of applying the current Federal Law of 09.01.1996 N 3-FL “On Radiation Safety of the Public” and other Russian laws regulating different aspects of human safety assurance in various fields. New law should be based on unconditional priority of protection of human life and health, present and future generations and the environment from possible radiation exposure. New law should enable interaction of the facilities whose activities are related to handling ionizing radiation sources and facilities of the infrastructure for radiation safety assurance, as well as provide connection to other regulations that set specific norms and requirements in the field of radiation safety assurance.
Risk Factors for Preeclampsia in Pregnant Women with Pregestational Diabetes
Authors: J Murillo-Llanes , Paulina Janet Montes-Esparza , Paula Flores-Flores , Jose Salvador Velarde-Felix , I Osuna-Ramirez , Gonzalez-Ibarra Fernando
Published: April 2024

Purpose: To estimate the incidence of preeclampsia in pregnant women with pregestational diabetes and to identify risk factors for preeclampsia. Material and methods: A retrospective cohort study of pregnant women with pregestational diabetes was conducted and compared with a random sample of non-diabetic pregnant women from the population served in the period from January 2017 to August 2019 at the Obstetrics Service of the Women's Hospital. By means of multiple logistic regression the risk factors for preeclampsia were estimated. Results: 10% and 90% of the cases were type 1 and type 2 diabetes mellitus respectively. The incidence of preeclampsia in pregestational diabetes mellitus was 22.5%. Chronic hypertension (OR: 28, CI95%4.8,164) for global PE, nulliparity (OR:6.8, CI95%1.6,36.2) for PE with SF, metabolic disorder (OR:8.4, CI95%1.3,54) for early-onset PE. Conclusions: Chronic hypertension, nulliparity, and metabolic disorder were risk factors for preeclampsia in pregnant women with pregestational diabetes.
Az anémia etiopatológiája, diagnózisa és kezelése gyulladásos bélbetegségekben
Authors: Resál Tamás , Molnár Tamás
Published: April 2024

Az anémia az egyik leggyakoribb komorbiditás gyulladásos bélbetegeknél (IBD), amelynek a hátterében leggyakrabban a vasháztartás zavara áll. Bár az anémia prevalenciája kifejezetten magas, és az életminőséget is jelentősen rontja, a pontos etiológia tisztázása és a kezelés is gyakran elmarad IBD-ben. Jelen összefoglaló közlemény célja, hogy bemutassa az anémia epidemiológiai adatait, segítse a fennálló vérszegénység etiopatológiai tisztázását, és ezáltal segítse a megfelelő terápia választását az anémia és a vasháztartás rendezésére.
A gasztrointesztinális eozinofil sejtek funkciói és heterogenitása
Authors: Bácsi Attila
Published: April 2024

Az eozinofília a gasztrointesztinális traktus számos krónikus gyulladásos állapotának egyik fő jellemzője. Ezen betegségek közül soknak az előfordulási gyakorisága drámai mértékben növekszik az iparosodott országokban. Ez az áttekintés összefoglalja a gasztrointesztinális eozinofilekkel, a sejtek effektor funkcióival, a nyálkahártya integritásának szabályozásában és a bélrendszeri immunválaszok modulálásában betöltött szerepükkel kapcsolatos ismereteket. A szöveti lokalizációban és funkcióban eltérő altípusaikat, valamint az állatmodellek és humán vizsgálatok által feltárt legfontosabb különbségeket is tárgyalja.
Le Malheur de Sophie et des autres: violences contre les petites filles dans l’œuvre romanesque de la comtesse de Ségur
Authors: Giacchetti Claudine Anne
Published: April 2024

In her novels, the comtesse de Ségur (1799–1874) often decried the harmful effects of punitive violence against little girls, although she also advocated its merits. As a pedagogical principle and an instrument of oppression, the use of force against female characters affects all social relations in the economy of her novels, from routine educational violence to physical assault. A sequential analysis of these phenomena will show how violence evolves in time and space through two corpuses of texts: the first three novels, or ‘Fleurville trilogy’ and the pair formed by the last two novels, Diloy le chemineau and Après la pluie le beau temps. We will also see how, in these narratives, the family as an institution, through its custodians, parents and surrogates, imposes on little girls a subtext of epistemic violence, embedded in the practice of ‘silencing’ the child victim.
Artaud et l’expérience des langues: les glossolalies comme performance thérapeutique
Authors: Philippe Maxime
Published: April 2024

After taking part in an art therapy experiment in 1943, Antonin Artaud started to include in his writings passages of an invented language that he connected to the tradition of glossolalia. I argue that the polyglottic dimension of this glossolalic practice is essential. After expounding the relationship of glossolalia to linguistic diversity, I will demonstrate how Artaud’s glossolalia conveys the poet’s linguistic experience. More specifically, I will emphasize the importance of the Raramuri rituals, which Artaud witnessed in Mexico in 1936, for the definition of his glossolalic practice. The Raramuri vision of an embodied and performed therapy inspired the poet to reclaim his agency in the process of art therapy. Artaud’s glossolalia corresponds to an art performance thought as such a therapy. This practice attempts to rebuild Babel, to simultaneously refound language and body.
Mémoire de fille (dé)rangée: relire Ernaux à la lumière de Beauvoir
Authors: Muller Justine
Published: April 2024

Simone de Beauvoir’s influence, particularly through her Second Sex and Memoirs of a Dutiful Daughter, has been personally and intellectually decisive for Annie Ernaux who just like Beauvoir turned from a both dutiful and disturbed girl into a disturbing author as evidenced by her narrative A Girl’s Story. This article precisely aims at studying how the ‘disturbed’ and ‘disturbing’ paradigms open the way to a reassessment of A Girl’s Story in light of Beauvoir’s Second Sex and Memoirs of a Dutiful Daughter, and bring so to the fore the organic bond connecting Ernaux to Beauvoir.
The application of propensity score methods in observational studies
Authors: Zhao Yuejuan
Published: April 2024

Introduction

In research, it is crucial to accurately estimate treatment effects and analyze experimental results. Common methods include comparing outcome differences between different groups and using linear regression models for analysis. However, observational studies may have significantly different distributions of confounding variables between control and treatment groups, leading to errors in estimating treatment effects.

Methods

The propensity score methods can address this issue by weighting or matching samples to approximate the scenario of a randomized experiment and allow for more accurate estimation of treatment this paper.

Results

We use propensity score methods to analyze three datasets from observational studies and draw conclusions different from those in the original text. Furthermore, we simulate three scenarios, and the results demonstrate the superiority of propensity score methods over methods such as linear regression in addressing selection bias.

Discussion

Therefore, it is essential to thoroughly consider the characteristics of the data and select appropriate methods to ensure reliable conclusions in practical data analysis.
Refraining from culture-related discussions in English as a foreign language classrooms: lessons from negative cases
Authors: Lavrenteva Evgenia , Orland-Barak Lily
Published: April 2024

Introduction

This study examined the factors that determined English as a Foreign Language (EFL) teacher decisions to refrain extending the use of culture-related classroom discussions. Specifically, we focused on the episodes in which teachers decided against holding specific culture-related discussions, to better understand the reasons for limited inclusion of diverse cultural content.

Methods

In our examination of the data, we opted for the Theory of Planned Behavior as a lens to interpret teachers' motives for deciding at will not to have a culture-related discussion. The study followed negative case methodology to gain insight into why teachers avoided classroom discussions about culture. Within this methodology, we applied the Possibility Principle to define and select relevant sample of cases. To analyse the cases, we employed hybrid approach of qualitative methods of thematic analysis.

Results

A thematic analysis of teacher interviews (N = 30) revealed that Israeli EFL teachers' decisions to refrain from culture-related classroom discussions were influenced by their personal norms and attitudes, perceptions of their roles as teachers, social conventions, and expectations of various school stakeholders. Specifically, we found that the major barriers to conducting culturally-related classroom conversations in the Arab sector had to do with the values endorsed by the school culture, with teachers' tendency to avoid taboo topics in their teaching due to concerns about how students would react or become alienated. For immigrant teachers, personal norms and perceptions of control operated as key factors in their decisions to avoid sensitive issues. Majority teachers cited negative attitudes, moral panics, school culture and perceptions of control as principal reasons for avoiding controversial topics.

Discussion

The emergent patterns are discussed as embedded in the cultural and social norms with possible implications for teaching in the multicultural classroom.
Scrolls and self-perception, navigating the link between social networks and body dissatisfaction in preadolescents and adolescents: a systematic review
Authors: Digennaro Simone , Tescione Alessia
Published: April 2024

In recent years, the widespread adoption of social media has immersed users in content dominated by conventional beauty ideals and the relentless pursuit of perfection. This pervasive influence has significantly altered the perceptual landscape for young individuals, particularly pre-adolescents and adolescents, shaping their self-evaluations and contributing to distorted notions of beauty. The virtual realm, saturated with carefully curated and idealized images promoting unattainable beauty standards, has intensified concerns about body image. This study aims to comprehensively examine the intricate interplay between social media use and the body image of preadolescents and adolescents. Through a meticulous systematic review of 16 studies, a consistent consensus emerges, highlighting a noteworthy correlation between key variables such as the duration of social media usage, problematic engagement patterns, specific activities within these platforms, and heightened levels of body dissatisfaction.
Impact of the diagnosis of metabolic dysfunction-associated fatty liver disease and non-alcoholic fatty liver disease in patients undergoing liver transplantation for hepatocellular carcinoma
Authors: Zhu Ji-Qiao , Liu Jia-Zong , Yang Shi-Wei , Ren Zhang-Yong , Ye Xiao-Yong , Liu Zhe , Li Xian-Liang , Han Dong-Dong , He Qiang
Published: April 2024

Purpose

Whether the diagnosis of non-alcoholic fatty liver disease or metabolic dysfunction-associated fatty disease has a different impact on liver transplant recipients with hepatocellular carcinoma is not yet clear.

Methods

Data from a two-center retrospective cohort study were collected to compare and investigate the differences between non-alcoholic fatty liver disease and metabolic dysfunction-associated fatty liver disease in clinicopathologic parameters and prognosis among liver transplant recipients with hepatocellular carcinoma.

Results

A total of 268 liver transplant recipients with hepatocellular carcinoma were included. The prevalence among pre- and post-transplant metabolic dysfunction-associated fatty liver disease was 10.82% and 30.22%, while for non-alcoholic fatty liver disease, it was 7.09% and 26.87%, respectively. The clinicopathological parameters were similar between the two pre-transplant groups. In contrast, the post-transplant group with metabolic dysfunction-associated fatty liver disease exhibited a higher prevalence of diabetes mellitus and a greater body mass index. However, the other parameters were similar between the two post-transplant groups (p > 0.05). Factors such as the largest tumor size > 4 cm, microvascular invasion, lack of tumor capsule, post-transplant metabolic dysfunction-associated fatty liver disease, and decreased post-transplant lymphocyte percentage were related to an increased risk of recurrence.

Conclusion

In patients undergone liver transplantation for hepatocellular carcinoma, the diagnosis of metabolic dysfunction-associated fatty disease is more strongly associated with metabolic abnormalities than the diagnosis of non-alcoholic fatty liver disease and is an independent predictor of hepatocellular carcinoma recurrence.
Intraoperative radiofrequency ablation for unresectable abdominal paraganglioma: a case report
Authors: Magalhaes Isabelle P. A. , Boger Bibiana D. , Gomes Nathalia L. , Martins Guilherme L. P. , Bomfim Leomarques A. , Fagundes Gustavo F. C. , Rocha Roberta S. , Coelho Fernando M. A. , Chambo Jose L. , Latronico Ana Claudia , Fragoso Maria Candida B. V. , Hoff Ana O. , Mendonca Berenice B. , Menezes Marcos R. , Almeida Madson Q.
Published: April 2024

For pheochromocytoma and paraganglioma (PPGL), the efficacy of percutaneous ablative therapies in achieving control of metastatic tumors measuring <3 cm had been demonstrated in only few reports, and intraoperative radiofrequency ablation (RFA) of locally invasive primary PPGLs has not been reported. We presented the case of a 31-year-old man who had a 9-cm functioning unresectable PPGL. He was treated with 13 cycles of cytotoxic chemotherapy without objective tumor response, according to the Response Evaluation Criteria in Solid Tumors (RECIST). Subsequently, magnetic resonance imaging revealed a 9.0 × 8.6 × 6.0-cm retroperitoneal mass that extended to the inferior portion of the inferior vena cava, the inferior mesenteric artery, and the infrarenal aorta. Biochemical evaluation demonstrated high level of plasma normetanephrine (20.2 nmol/L, normal range <0.9 nmol/L). Genetic investigation showed the germline pathogenic variant c.1591delC (p. Ser198Alafs*22) in the SDHB gene. I131-metaiodobenzylguanidine scintigraphy was negative and Ga68-dotatate PET-CT scan showed high tumor uptake without distant metastases. On open laparotomy, tumor debulking was not possible. Therefore, intraoperative RFA was performed by a highly experienced team of interventional radiologists. At 12 months after the RFA, the tumor volume decreased from 208 to 45 mL (78%), plasma normetanephrine decreased from 20.2 to 2.6 nmol/L (87%), and the doxazosin dose was reduced from 16 to 8 mg/day. To our best knowledge, this was the first report on intraoperative RFA that markedly reduced the size of a large primary unresectable PPGL, along with clinical and biochemical responses.
The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018
Authors: Wang Lixia , Gao Jie , Liu Bing , Fu Youliang , Yao Zhihui , Guo Shanshan , Song Ziwei , Zhang Zhaoyuan , He Jiaojiao , Wang Congxia , Ma Weidong , Wu Feng
Published: April 2024

Objective

Obesity, hypertension and diabetes are high prevalent that are often associated with poor outcomes. They have become major global health concern. Little research has been done on the impact of lymphocyte-to-monocyte ratio (LMR) on outcomes in these patients. Thus, we aimed to explore the association between LMR and all-cause mortality in obese hypertensive patients with diabetes and without diabetes.

Methods

The researchers analyzed data from the National Health and Nutrition Examination Survey (2001-2018), which included 4,706 participants. Kaplan-Meier analysis was employed to compare survival rate between different groups. Multivariate Cox proportional hazards regression models with trend tests and restricted cubic splines (RCS) analysis and were used to investigate the relationship between the LMR and all-cause mortality. Subgroup analysis was performed to assess whether there was an interaction between the variables.

Results

The study included a total of 4706 participants with obese hypertension (48.78% male), of whom 960 cases (20.40%) died during follow-up (median follow-up of 90 months). Kaplan–Meier curves suggested a remarkable decrease in all-cause mortality with increasing LMR value in patients with diabetes and non-diabetes (P for log-rank test < 0.001). Moreover, multivariable Cox models demonstrated that the risk of mortality was considerably higher in the lowest quartile of the LMR and no linear trend was observed (P > 0.05). Furthermore, the RCS analysis indicated a non-linear decline in the risk of death as LMR values increased (P for nonlinearity < 0.001).

Conclusions

Increased LMR is independently related with reduced all-cause mortality in patients with obese hypertension, regardless of whether they have combined diabetes.
Unified power quality conditioner-based solar EV charging station using the GBDT–JS technique
Authors: Prasada Rao Ch. S. V. , Pandian A. , Reddy Ch. Rami , Bajaj Mohit , Massoud Jabir , Shouran Mokhtar
Published: April 2024

This manuscript proposes a novel hybrid artificial intelligence (AI) approach for a unified power quality conditioner (UPQC) designed specifically for electric vehicle charging stations (EVCSs). The aim is to integrate multiple vehicle-to-grid (V2G) functionalities, thereby mitigating the challenges associated with electric vehicle (EV) grid integration and the incorporation of distributed energy resources (DERs). The hybrid technique presented in this manuscript combines the gradient boosting decision tree (GBDT) algorithm and the jellyfish search (JS) algorithm, referred to as the GBDT–JS technique. This innovative approach involves utilizing the charging station to offer EV charging services and facilitating the discharge of EVs to the power grid. Integration of the UPQC with DERs, such as photovoltaic (PV), is implemented to decrease the power rating of converters and fulfill power demand requirements. The initial converter within the UPQC is employed to manage the direct current (DC) voltage, while the second converter oversees the power charging or discharging processes of EVs. Additionally, it mitigates the impact of battery voltage fluctuations. The UPQC with vehicle-to-grid functionality minimizes the load pressure on the grid, preventing over-current issues. The presented approach regulates the UPQC converters to mitigate power quality issues such as harmonic currents and voltage sags. Subsequently, the effectiveness of this technique is demonstrated using the MATLAB/Simulink operating platform. The evaluation of GBDT–JS performance involves a comparative analysis with existing techniques. This assessment reveals that the proposed method effectively alleviates power quality issues, specifically reducing total harmonic distortion (THD), and delivers optimal outcomes.
When the woolly rhinoceroses roamed East Asia: a review of isotopic paleoecology of the genus Coelodonta from the Tibetan Plateau to northern Eurasia
Authors: Ma Jiao , Wang Shiqi , Deng Tao
Published: April 2024

East Asia, being the evolutionary center of Coelodonta, offers a unique opportunity to explore the spatiotemporal paleoecologies of this genus. This study utilized bulk and serial stable carbon and oxygen isotope analyses on the Coelodonta nihowanensis and other ungulates from the Longdan fauna as well as two modern goats in the Linxia Basin, aiming to explore the paleoecology of C. nihowanensis at the periphery of the Tibetan Plateau during the Early Pleistocene. The isotopic results of these mammals indicated that C3 vegetation was possibly a major component of the local environment in the Linxia Basin, which was influenced by a seasonal summer monsoon. C. nihowanensis specimens in the Longdan fauna were possibly mixed feeders, as indicated by the wide distribution of their δ13C values and the intermediate δ18O values compared to other coexisting ungulates. Moreover, the comparison of the δ13C and δ18O values of similar taxa from the Linxia and Nihewan basins has revealed spatiotemporal differences in the paleoclimate and paleoenvironments of these two regions throughout the Early Pleistocene. This provides a holistic framework for understanding the paleoecology of the C. nihowanensis. The isotopic results of the C. nihowanensis in the Linxia and Nihewan basins suggested varied foraging ecologies across different sites and time spans during the Early Pleistocene. This underscores the adaptability of the C. nihowanensis to diverse environments from west to east in northern China. By scrutinizing the evolutionary ecological history of the woolly rhinoceroses from its ancestor, Coelodonta thibetana, to its final form, Coelodonta antiquitatis, this study sheds light on the ecological adaptation of this genus from the Pliocene to Late Pleistocene, spanning its migration from the Tibetan Plateau to northern Eurasia.
Application and perspective of CRISPR/Cas9 genome editing technology in human diseases modeling and gene therapy
Authors: Zhang Man-Ling , Li Hong-Bin , Jin Yong
Published: April 2024

The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) mediated Cas9 nuclease system has been extensively used for genome editing and gene modification in eukaryotic cells. CRISPR/Cas9 technology holds great potential for various applications, including the correction of genetic defects or mutations within the human genome. The application of CRISPR/Cas9 genome editing system in human disease research is anticipated to solve a multitude of intricate molecular biology challenges encountered in life science research. Here, we review the fundamental principles underlying CRISPR/Cas9 technology and its recent application in neurodegenerative diseases, cardiovascular diseases, autoimmune related diseases, and cancer, focusing on the disease modeling and gene therapy potential of CRISPR/Cas9 in these diseases. Finally, we provide an overview of the limitations and future prospects associated with employing CRISPR/Cas9 technology for diseases study and treatment.