bluuebunny/crossref_metadata_2025 huggingface dataset:
Care Fragmentation in Patients with Differentiated Thyroid Cancer
Authors: Greenberg Jacques A. , Thiesmeyer Jessica W. , Egan Caitlin E. , Lee Yeon Joo , Sivarajah Maheshwaran , Zarnegar Rasa , Fahey Thomas J. , Beninato Toni , Finnerty Brendan M.
Published: August 2022

Background

Among surgical patients, care fragmentation (CF) is associated with worse outcomes. However, oncologic literature documents an association between high surgical volume and improved outcomes, favoring centralized cancer‐surgery centers and thus predisposing to CF in patients with surgically treated tumors. We aimed to identify features associated with CF and ascertain differences in overall survival (OS) among patients with differentiated thyroid cancer (DTC).

Methods

The National Cancer Database was queried for DTC patients diagnosed from 2009 to 2017. Patients experienced CF if part of their treatment was performed outside of the reporting facility or an associated office. A multivariable logistic regression analysis identified independent features associated with CF. A Cox multivariable regression analysis assessed the impact of CF on OS. A Kaplan–Meier analysis compared survival differences between patients experiencing CF or unified care (UC).

Results

A total of 131,620 patients were included. Among them, 70,204 (53.3%) experienced CF and 61,416 (46.7%) experienced UC. Age < 55, residing in high‐income areas, and stage 3 and 4 tumors were features independently associated with CF, whereas uninsured patients were less likely to experience CF than the privately insured. The features most strongly associated with CF were treatment at highest thyroid cancer‐surgery volume institutions and traveling in the top distance quartile. While patients with CF experienced minor delays in time from diagnosis to surgery, 5‐year OS was improved among patients with CF compared to UC for those with Stage 1–3 disease.

Conclusions

Among patients with DTC, CF is associated with treatment at a highest thyroid cancer surgery volume facility and improved OS in a setting of minor treatment delays.
Feasibility of pressurized intra peritoneal aerosol chemotherapy using an ultrasound aerosol generator (usPIPAC)
Authors: Höltzcke Phil , Sautkin Iaroslav , Clere Samuel , Castagna Arianna , Königsrainer Alfred , Pott Peter P. , Reymond Marc A.
Published: August 2022

Background

We tested the feasibility of ultrasound technology for generating pressurized intraperitoneal aerosol chemotherapy (usPIPAC) and compared its performance vs. comparator (PIPAC).

Material and methods

A piezoelectric ultrasound aerosolizer (NextGen, Sinaptec) was compared with the available technology (Capnopen, Capnomed). Granulometry was measured for water, Glc 5%, and silicone oil using laser diffraction spectrometry. Two- and three-dimensional (2D and 3D) spraying patterns were determined with methylene blue. Tissue penetration of doxorubicin (DOX) was measured by fluorescence microscopy in the enhanced inverted Bovine Urinary Bladder model (eIBUB). Tissue DOX concentration was measured by high-performance liquid chromatography (HPLC).

Results

The droplets median aerodynamic diameter was (usPIPAC vs. PIPAC): H20: 40.4 (CI 10–90%: 19.0–102.3) vs. 34.8 (22.8–52.7) µm; Glc 5%: 52.8 (22.2–132.1) vs. 39.0 (23.7–65.2) µm; Silicone oil: 178.7 (55.7–501.8) vs. 43.0 (20.2–78.5) µm. 2D and 3D blue ink distribution pattern of usPIPAC was largely equivalent with PIPAC, as was DOX tissue concentration (usPIPAC: 0.65 (CI 5-95%: 0.44–0.86) vs. PIPAC: 0.88 (0.59–1.17) ng/ml, p = 0.29). DOX tissue penetration with usPIPAC was inferior to PIPAC: usPIPAC: 60.1 (CI 5.95%: 58.8–61.5) µm vs. PIPAC: 1172 (1157–1198) µm, p < 0.001). The homogeneity of spatial distribution (top, middle and bottom of the eIBUB) was comparable between modalities.

Discussion

usPIPAC is feasible, but its performance as a drug delivery system remains currently inferior to PIPAC, in particular for lipophilic solutions.
Changing the tracks: screening for electron transfer proteins to support hydrogen production
Authors: Günzel Alexander , Engelbrecht Vera , Happe Thomas
Published: August 2022

Ferredoxins are essential electron transferring proteins in organisms. Twelve plant-type ferredoxins in the green alga Chlamydomonas reinhardtii determine the fate of electrons, generated in multiple metabolic processes. The two hydrogenases HydA1 and HydA2 of. C. reinhardtii compete for electrons from the photosynthetic ferredoxin PetF, which is the first stromal mediator of the high-energy electrons derived from the absorption of light energy at the photosystems. While being involved in many chloroplast-located metabolic pathways, PetF shows the highest affinity for ferredoxin-NADP+ oxidoreductase (FNR), not for the hydrogenases. Aiming to identify other potential electron donors for the hydrogenases, we screened as yet uncharacterized ferredoxins Fdx7, 8, 10 and 11 for their capability to reduce the hydrogenases. Comparing the performance of the Fdx in presence and absence of competitor FNR, we show that Fdx7 has a higher affinity for HydA1 than for FNR. Additionally, we show that synthetic FeS-cluster-binding maquettes, which can be reduced by NADPH alone, can also be used to reduce the hydrogenases. Our findings pave the way for the creation of tailored electron donors to redirect electrons to enzymes of interest.

Graphical abstract
Maxillary lateral incisor agenesis is associated with maxillary form: a geometric morphometric analysis
Authors: Nemec Michael , Schwarz Linda , Bertl Michael H. , Bertl Kristina , Gahleitner André , Mitteroecker Philipp , Jonke Erwin
Published: August 2022

Background and objective

Agenesis of the maxillary lateral incisor occurs in up to 4% of all individuals and requires multidisciplinary treatment. Its developmental origins, however, are not fully understood. Earlier studies documented genetic factors contributing to agenesis but also an association with craniofacial morphology. In this study, we assessed the association between maxillary morphology and lateral incisor agenesis by a geometric morphometric approach to disentangle the roles of developmental plasticity and genetic factors.

Materials and methods

We quantified the maxillary alveolar ridge by 19 two-dimensional landmarks on cross-sectional images of 101 computed tomography scans. We compared the shape and size of the alveolar ridge across patients with unilateral or bilateral agenesis of maxillary lateral incisors and patients with extracted or in situ incisors.

Results

The maxillary alveolar ridge was clearly narrower in patients with agenesis or an extracted incisor compared to the control group, whereas the contralateral side of the unilateral agenesis had an intermediate width. Despite massive individual variation, the ventral curvature of the alveolar ridge was, on average, more pronounced in the bilateral agenesis group compared to unilateral agenesis and tooth extraction.

Conclusions

This suggests that pleiotropic genetic and epigenetic factors influence both tooth development and cranial growth, but an inappropriately sized or shaped alveolar process may also inhibit normal formation or development of the tooth bud, thus leading to dental agenesis.

Clinical relevance

Our results indicate that bilateral agenesis of the lateral incisor tends to be associated with a higher need of bone augmentation prior to implant placement than unilateral agenesis.
Potential and challenges of tool condition monitoring in gear hobbing
Authors: Hendricks Steffen , Troß Nico , Brimmers Jens , Bergs Thomas
Published: August 2022

Due to its high productivity, gear hobbing is one of the most frequently used manufacturing processes for the soft machining of cylindrical gears. One of the main objectives of an optimized manufacturing process is to maintain the required component quality while minimizing manufacturing costs. In both cases, knowledge of the tool wear is of great importance. Tool Condition Monitoring (TCM) provides a methodical approach to tracking tool wear during the process. In this report, various sensors are investigated with regard to their potential for TCM. Fly-cutting and hobbing experiments were conducted for this purpose. The signal data recorded during the tests were processed using high-pass filters, Hilbert transforms and Fast Fourier Transforms (FFT) in the time and frequency domain and evaluated according to various parameters. Based on the results, statements were made about the relationships between signal data and process conditions. For a precise evaluation of the tool condition, the combination of several sensors is necessary. In particular, the tool-side-mounted acoustic emission and acceleration sensors in combination with the power sensor and the airborne sound sensor showed increased amplitude values with increased wear. For the acceleration signals it could be shown that higher orders reacted more sensitively to increased tool wear. For the workpiece-side-mounted sensors, no meaningful results could be obtained due to the large distance to the cutting zone.
Early Differentiation of the Phenotypic Space and Performance of Juniperus thurifera Across Woodland-Expanding Areas
Authors: Benavides Raquel , Acuña-Míguez Belén , Valladares Fernando
Published: August 2022

Forest expansion after rural abandonment is changing landscapes, bringing new challenges and opportunities. Juvenile performance has an effect in the establishment of new forests and the subsequent acclimation of adult trees. However, most studies have focused on the performance of adult trees. Here, we analysed differences in the phenotypic trait space of juveniles across gradients of Juniperus thurifera woodland expansion and explored which traits shape juveniles’ performance, seeking specific drivers of such differentiation and the role of the ontogeny. Thus, we surveyed functional leaf and plant-size traits in 180 juveniles growing in 18 plots at three different tree density stages (mature woodland, recently established area and a transition zone between both) and recorded local environmental conditions around each individual. We also estimated their radial growth and resilience to drought (in terms of resistance, recovery and resilience) as performance indicators. We found no relevant effects of the study environmental variables, but we did find a shift in the phenotypic space among juveniles across the gradient, with taller crowns and higher amount of leaf N and δ13C at the expanding edge. This trait differentiation across the gradient implied higher performance of young trees growing in old agricultural fields, both in growth rate and drought resilience terms. Our results showed a relevant land-use legacy on early trait differentiation that shapes more efficient phenotypes in the expanding edge compared to those in mature woodlands, suggesting that the future of these new forests is not compromised under current conditions.
Effect of Potassium Silicate and Irrigation on Grain Nutrient Uptake and Water Use Efficiency of Wheat Under Calcareous Soils
Authors: Saudy Hani Saber , Salem Emad M. M. , Abd El-Momen Wasfi Ramadan
Published: August 2022

In calcareous soil, two field experiments were conducted to investigate the effects of two potassium silicate treatments (with and without) and three irrigation levels (100, 80 and 60%, of crop evapotranspiration, abbreviated as IW100, IW80 and IW60, respectively) on wheat yield and nutrient uptake and water use efficiency (WUE). The experimental design was a strip plots design in randomized complete block arrangement with three replicates. Findings reveal that potassium silicate improved grain weight spike−1 by about 1.06 times whether with IW80 or IW60. Also, seed index increased by 1.03, 1.06 and 1.04 times owing to potassium silicate in the 1st season under IW100, IW80 and IW60 treatments, respectively. Application of potassium silicate surpassed the control treatment by about 1.05, 1.4 and 1.07 times for biological straw and grain yields under IW80. The interaction of IW80 × potassium silicate significantly equaled IW100 × potassium silicate for P, S Mg and Mn uptake in both seasons as well as N, K and Zn uptake in the 1st season and Fe uptake in the 2nd season. IW80 or IW60 with potassium silicate application were the efficient combinations for improving WUE in both growing seasons.
Abundance and seasonality of phoronid larvae in coastal temperate waters: More abundant than previously thought?
Authors: McGuinness Maria , Brownlow Hannah , McAllen Rob , Harman Luke , Haberlin Damien , Doyle Thomas K.
Published: August 2022

In zooplankton surveys, many smaller taxa or species considered less important are often overlooked. One such example is the actinotrocha larvae of phoronid worms that are rarely quantified in zooplankton samples yet may play important roles in marine food webs. To gain a better understanding of phoronid ecology in coastal waters, we retrospectively analysed 145 plankton samples collected from two coastal sites in Ireland (Lough Hyne and Bantry Bay). Samples were collected using plankton nets from depths of 20 and 40 m. Phoronids were present in 37.7% and 38.2% of samples, with mean abundances of 0.3 ± 0.5 ind. m−3 and 1.2 ± 2.8 ind. m−3, respectively, and were identified as Phoronis muelleri and Phoronis hippocrepia. Phoronids were present consistently each year from April to October at Lough Hyne and from February to October at Bantry Bay. Comparisons with other taxa in Lough Hyne show that abundances are similar to those of fish larvae (1.1 ± 1.8 ind. m−3) and echinoderm larvae (2.3 ± 4.4 ind. m−3). Examination of these samples from Irish waters suggests that phoronids are more abundant in temperate waters than previously reported.
Cushing’s disease: adrenal steroidogenesis inhibitors
Authors: Pivonello Rosario , Simeoli Chiara , Di Paola Nicola , Colao Annamaria
Published: August 2022

Cushing’s disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of Cushing’s syndrome (CS), accounting for approximately 70% of cases. CD requires a prompt diagnosis, an adequate treatment selection, and long-term management to limit hypercortisolism duration and long-term complications and improve patient outcomes. Pituitary surgery is the first-line option, which is non-curative in one third of patients, therefore requiring additional treatments. Medical therapy has recently acquired an emerging role, with the availability of several drugs with different therapeutic targets, efficacy and safety profiles. The current review focuses on efficacy and safety of steroidogenesis inhibitors, and particularly the historical drugs, ketoconazole and metyrapone, and the novel drugs levoketoconazole and osilodrostat, which seem to offer a rapid, sustained, and effective disease control. Ketoconazole should be preferred in females and in patients without severe liver disease; levoketoconazole may offer an alternative to classical ketoconazole, appearing characterized by a higher potency and potential lower hepatotoxicity compared to ketoconazole. Metyrapone should be preferred in males and in patients without severe or uncontrolled hypokalemia. Both ketoconazole and metyrapone may be preferred for short-term more than for long-term treatment. Osilodrostat may represent the best choice for long-term treatment, in patients with poor compliance to the multiple daily administration schedule, and in patients without severe or uncontrolled hypokalemia. Steroidogenesis inhibitors may be used alone or in combination, and associated with pituitary directed drugs, to improve the efficacy of the single drugs, allowing a potential use of lower doses for each drug, and hypothetically reducing the rate of adverse events associated with the single drugs. Clinicians may tailor medical therapy on the specific clinical scenario, considering disease history together with patients’ characteristics and hypercortisolism’s degree, addressing the needs of each patient in order to improve the therapeutic outcome and to reduce the burden of illness, particularly in patients with persistent or recurrent CD.
Correlation of UAV and satellite-derived vegetation indices with cotton physiological parameters and their use as a tool for scheduling variable rate irrigation in cotton
Authors: Lacerda L. N. , Snider J. , Cohen Y. , Liakos V. , Levi M. R. , Vellidis G.
Published: August 2022

Current irrigation management zones (IMZs) for variable rate irrigation (VRI) systems are static. They are delineated in the beginning of the season and used thereafter. However, recent research has shown that IMZ boundaries are transient and change with time during the growing season. The primary goal of this study was to explore the potential of using vegetation indices (VIs) developed from unmanned aerial vehicle (UAV) and satellite images to predict cotton physiological parameters that can be used to delineate in-season boundaries of IMZs. A 2 year study was conducted in a 38 ha commercial cotton field in southwestern Georgia, USA. Throughout the two growing seasons, VIs were calculated from UAV, PlanetScope, and Sentinel-2 images. Predawn leaf water potential (LWPPD) and plant height were measured at 37 locations in the field on the same day as the flights and correlated with UAV and satellite based-VIs. GNDVI (Green normalized difference vegetation index) was the best predictor of plant height with correlation values of 0.72 (p < .0001) and 0.84 (p < .0001) for 2019 and 2020, respectively. A secondary goal was to compare the performance of dynamic VRI (DVRI) to conventional irrigation. The field was divided into alternating parallel conventional, and DVRI strips to compare the two scheduling methods. The conventional strips were irrigated using the farmer’s standard method and individual IMZs within the DVRI strips were irrigated based on soil water tension (SWT) measured with a wireless soil moisture sensor network. LWP and SWT measurements correlated well. IMZs were initially delineated using soil texture, apparent soil electrical conductivity (ECa), and yield maps and satellite images from previous years and were modified in-season to reflect patterns observed in the plant height maps. In 2020, the DVRI system prescribed an average irrigation amount of 50.8 mm while conventional irrigation applied an average of 58.4 mm. Average yields for DVRI and conventional were 1248 and 1191 kg ha−1, respectively. The DVRI system resulted in average yield 4.6% higher than conventional irrigation, while applying 14.0% less water. Despite the lower water application by the DRVI system, the performance comparison between the DRVI and the conventional irrigation was not conclusive.
Psychometric properties of kidney disease quality of life-36 (KDQOL-36) in dialysis patients in Indonesia
Authors: Rokhman M. Rifqi , Wardhani Yulia , Partiningrum Dwi Lestari , Purwanto Barkah Djaka , Hidayati Ika Ratna , Idha Arofa , Thobari Jarir At , Postma Maarten J. , Boersma Cornelis , van der Schans Jurjen
Published: August 2022

Objective

The study aimed to evaluate the psychometric properties of KDQOL-36 Bahasa Indonesia in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients in Indonesia.

Methods

The psychometric analysis was conducted in three hospitals offering both HD and CAPD. The validity was assessed through structural, convergent, and known-group validity, while reliability was evaluated using internal consistency and test–retest reliability.

Results

The study involved 370 participants of which 71% received HD treatment. No floor and ceiling effects (< 10%) were identified. Confirmatory factor analysis supported a good model fit for both generic and kidney-specific domains, while exploratory factor analysis revealed three factors for kidney-specific domains and only three items with a loading factor below 0.4. Convergent validity showed positive correlations between kidney-specific domains, generic domains, and EQ-5D. The comparison of quality of life among subgroups based on dialysis type and whether or not patients had diabetes supported the hypotheses of known-group validity. Cronbach’s alpha and omega values had demonstrated good internal consistency. Test–retest reliability indicated burden of kidney disease had good reliability, while other domains had moderate reliability.

Conclusion

The study supports the validity and reliability of both generic and kidney-specific domains of KDQOL-36 Bahasa Indonesia to evaluate quality of life in patients with HD and CAPD in Indonesia. As health-related quality of life is a crucial predictor of patient outcomes, this report contributes new evidence about validity and reliability to recommend the use of KDQOL-36 Bahasa Indonesia in dialysis centers.
Privacy-preserving edge computing offloading scheme based on whale optimization algorithm
Authors: Liu Zhenpeng , Wang Jingyi , Gao Zilin , Wei Jianhang
Published: August 2022

Aiming at the problem of user’s task offloading in mobile edge computing and the potential leakage of location privacy during the offloading process, a privacy-preserving computing offloading scheme based on whale optimization algorithm is proposed. Using differential privacy technology to obfuscate the user's location information, the user can make task offloading decisions according to the obfuscated distance. Considering the delay, energy consumption, and their weighted sum, the offloading problem is modeled as a convex optimization problem. Then, the whale optimization algorithm is adopted to solve this optimization problem to achieve a balance between privacy protection and resource consumption. Experiments are conducted to verify the relationship between the degree of privacy leakage, the computation-offloading cost and real distance, privacy-preserving impact factor, the respective weights of time delay and energy consumption The experimental results show that the offloading scheme proposed in this paper has good performance in terms of cost and privacy protection.
Pharmacokinetic and pharmacodynamic profiles of a novel phospholipid-aspirin complex liquid formulation and low dose enteric-coated aspirin: results from a prospective, randomized, crossover study
Authors: Franchi Francesco , Schneider David J. , Prats Jayne , Fan Weihong , Rollini Fabiana , Been Latonya , Taatjes-Sommer Heidi S. , Bhatt Deepak L. , Deliargyris Efthymios N. , Angiolillo Dominick J.
Published: August 2022

Low dose enteric-coated aspirin (EC-ASA) is routinely used for secondary cardiovascular event prevention. However, absorption of EC tablets is poor, which can result in subtherapeutic antiplatelet effects. Phospholipid-aspirin liquid filled capsules (PL-ASA) are a novel FDA-approved immediate-release formulation designed to reduce gastrointestinal (GI) injury by limiting direct contact with the stomach lining. We compared the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of PL-ASA versus EC-ASA at a low dose. This randomized, open-label, crossover study assessed PK and PD following a single 81-mg dose of PL-ASA versus EC-ASA under fasting conditions in 36 volunteers without cardiovascular disease between 18 and 75 years of age. Volunteers were randomly assigned 1:1 to either PL-ASA then EC-ASA or vice versa with a minimum 14-day washout. Assessments included PK parameters for acetylsalicylic acid and salicylic acid, platelet aggregation in response to arachidonic acid (AA), and serum thromboxane B2 (TxB2) assessments over 24 h. PL-ASA was rapidly absorbed. PL-ASA reached Tmax 3 h earlier (1.01 vs. 4.00 h, p < 0.0001), with almost double the Cmax (720 vs. 368 ng/mL, p < 0.0001) and overall 44% higher exposure of acetylsalicylic acid (AUC0-t: 601 vs. 416 h*ng/mL, p = 0.0013) compared with EC-ASA. Within 1 h of dosing, PL-ASA achieved significantly lower residual platelet aggregation, which persisted for the full 24 h (median AA-LTA was 47% with PL-ASA vs. 80.5% with EC-ASA; p = 0.0022 at hour-24). Treatment with PL-ASA also resulted in significantly lower serum TxB2 concentrations at each time point compared with EC-ASA (all p-values < 0.05). PL-ASA resulted in faster and more complete aspirin absorption paralleled by more prompt and potent platelet inhibition compared with EC-ASA after a single 81 mg dose. PL-ASA represents an attractive novel aspirin formulation for the secondary prevention of cardiovascular events.

Clinical Trial Registration ClinicalTrials.gov identifier: NCT04811625.
Effects of air pollution on myopia: an update on clinical evidence and biological mechanisms
Authors: Yuan Tianyi , Zou Haidong
Published: August 2022

Myopia is one of the most common forms of refractive eye disease and considered as a worldwide pandemic experienced by half of the global population by 2050. During the past several decades, myopia has become a leading cause of visual impairment, whereas several factors are believed to be associated with its occurrence and development. In terms of environmental factors, air pollution has gained more attention in recent years, as exposure to ambient air pollution seems to increase peripheral hyperopia defocus, affect the dopamine pathways, and cause retinal ischemia. In this review, we highlight epidemiological evidence and potential biological mechanisms that may link exposure to air pollutants to myopia. A thorough understanding of these mechanisms is a key for establishing and implementing targeting strategies. Regulatory efforts to control air pollution through effective policies and limit individual exposure to preventable risks are required in reducing this global public health burden.
On the automatic parameter calibration of a hypoplastic soil model
Authors: Machaček Jan , Staubach Patrick , Tavera Carlos Eduardo Grandas , Wichtmann Torsten , Zachert Hauke
Published: August 2022

This paper presents an approach for the automatic parameter calibration (AC) of a hypoplastic constitutive soil model. The calibration software developed in this work simplifies the parameter calibration, reduces the subjective “human” factor on the calibration result and lowers the entry hurdle for the use of the hypoplastic constitutive model. The performance of the software was demonstrated by comparing automatically calibrated parameter sets for two sands and their related simulations of the underlying experimental data with simulations using two reference parameter sets. The first reference parameter set was calibrated the classical way, "by hand", and the second was calibrated using the AC tool ExCalibre. Two different optimization methods were used, namely the Differential Evolution (DE) and the Particle Swarm Optimization (PSO). The simulations performed with the parameters obtained from the AC agree well with the experimental data and show improvements over the reference parameter sets. With respect to the optimization method, the performance of the DE proved superior to that of the PSO. Various measures of comparison were examined to quantify the discrepancy between experiment and simulation. By repeating 500 calibration runs, the dispersion of parameters was determined and correlations between different parameters of the hypoplastic model were found.
Lean Implementation for Graduating Optimally Controlled Stable Type 2 Diabetics from Endocrine Specialty Clinic Back to Primary Care
Authors: Burmeister Lynn A. , Harper Peter G. , Brueggemann Alvina , Adam Patricia , Logeais Mary , Schechter Kelly , Duncan Katie , Boyer Holly
Published: August 2022

Introduction

Endocrine specialty clinics (SCs) are occupied by a high percentage of stable follow-up patients, limiting access to new patients with greater needs.

Aim

Feasibility project to improve access to diabetes SC by reducing the number of stable optimally controlled follow-up type 2 diabetic patients.

Setting

M Health Fairview (MHFV), a hybrid network of University of Minnesota academic and Fairview Health community hospitals and clinics with affiliated providers.

Program Description

A team-based lean methodology quality improvement graduation program including medical assistants, nurses, physicians, and a compact with primary care (PC) was used to identify within the Endocrine clinic population the graduation-eligible optimally controlled stable type 2 diabetic patients, acclimate them to the graduation concept, engage in shared decision-making, and transition them back to PC with a warm hand-off and graduation certificate.

Program Evaluation

Seventeen percent (58/341) of eligible patients with optimally controlled diabetes graduated by 6 months, ranging between 0 and 83% per week.

Discussion

The innovation and feasibility of opening SC access through the use of a team-based graduation program to transfer stable diabetes patients back to their home clinic was demonstrated. This innovation has the potential to support health system triage of new patients to limited access specialty care.
Datenjournalismus in Deutschland revisited
Authors: Weinacht Stefan , Spiller Ralf
Published: August 2022

Der Datenjournalismus wird gleichermaßen stark in der Nachrichtenbranche beobachtet und in der Journalismusforschung reflektiert. Dieser Beitrag beschreibt das Phänomen zunächst im Kontext des Megatrends der Automatisierung des Journalismus. Anschließend wird die erste Trendstudie zum Datenjournalismus in Deutschland vorgestellt: Die Berufsfeldstudie war 2012 und 2019 im Feld. Die gewählten Items ermöglichen einen Längsschnitt-Vergleich der Entwicklung des Datenjournalismus. Bei einem Vergleich mit den nationalen Daten der „Worlds of Journalism Study“ werden weitere Gemeinsamkeiten und Unterschiede deutlich. Die Ergebnisse zeigen, dass sich der Datenjournalismus in Deutschland zunehmend institutionalisiert hat und Datenjournalist:innen sich stark einem investigativen politischen Journalismus verpflichtet fühlen.
Influence of Metal Flank Hardness of Machined and Cold Forged Gears on Wear within a Metal-Polyamide Gear Pair and Targeted Process Adaptation
Authors: Rohrmoser Andreas , Merklein Marion
Published: August 2022

Metal-polyamide gear pairs provide advantages but their application is limited due to wear. The properties of the metallic gearing significantly affect the wear behavior. However, the influence of varying metallic materials as well as flank hardness is not known. Within this contribution, the occurring wear mechanisms when applying steel, brass and aluminum with varying hardness resulting from manufacturing by machining and cold forging were identified. Depending on the hardness of the metallic tooth flank, the release of metallic particles (3-body abrasion) or surface roughening (2-body abrasion) results. The formation of a wear-reducing transfer film is only possible with sufficient strength of the metallic tooth flank and tribological compatibility. Maximum wear occurs at a metal hardness of about 120 HV due to 3-body abrasion with high abrasive effect of the metallic particles. The adaptation of the cold forging process enables a local increase in the plastic strain of the tooth flank by 84% resulting in an elevated tooth flank hardness (+ 53%) for aluminum and significantly reduced wear. Furthermore, the formation of a wear-reducing transfer film results. Aluminum pinions produced in the adapted cold forging process achieve performance level of steel within the investigated load case.
Detoxification enzyme activity, reproductive and developmental fitness of abamectin-resistant Bryobia praetiosa (Acari:Tetranychidae)
Authors: Ou Chun , Jiang Nan , Cheng Wenhui , Lei Tiantian , Jiang Shuanglin , Yao Xiamei
Published: August 2022

Abamectin is an important and environmentally friendly antibiotic pesticide, and its resistance has become an area of intense research. In this study, we employed laboratory bioassays, biochemical analyses, and life history analyses to systematically evaluate abamectin resistance, the underlying biochemical mechanisms of resistance, and the reproductive and developmental characteristics of the arthropod pest Bryobia praetiosa. An abamectin-resistant B. praetiosa strain (RR) was obtained by intensive selection of an abamectin-susceptible strain (SS) using abamectin exposure in the laboratory for 24 generations, yielding a resistance index (RI) of 30.11. Comparison of detoxification enzymes suggested that the specific activities of carboxylesterases (CarEs), glutathione S-transferases (GSTs), and mixed-function oxidases (MFOs) in the RR strain were higher than those of the SS strain by 1.13-, 1.75-, and 4.02-fold, respectively. GST and MFOS protein concentrations were also significantly different between RR and SS strains. Further analysis of life history parameters demonstrated that the developmental duration and lifespan of RR strain in addition to egg numbers were markedly decreased relative to SS strain. The net reproductive rate (R0), finite rate of increase (λ), and population doubling time (Dt) of RR strain were significantly lower than those of SS strain. The results indicated that the RR strain was more disadvantageous in developmental and reproductive characteristics than the SS strain. In addition, the relative fitness value of the resistant strain is about half (Rf = 0.49) that of the susceptible strain. In conclusion, increased abamectin resistance in B. praetiosa was associated with a rapid increase in MFOs activity, while GSTs also played a role in abamectin resistance development and RR strain exhibited reproductive disadvantages.
Cytoreductive Surgery and HIPEC for Regionally Advanced Gallbladder Cancer: a Case Report
Authors: Huang Fay , Shamavonian Raphael , Morris David L.
Published: August 2022

Gallbladder cancer is a rare cancer, associated with an extremely poor prognosis. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is not commonly performed in gallbladder cancer; however, case series have shown prolonged survival time with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gallbladder cancer and no increase in morbidity compared to cytoreductive surgery without hyperthermic intraperitoneal chemotherapy. We present a case of gallbladder cancer with peritoneal metastases in a 60-year-old male who was successfully treated with complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and survived for 4 years following diagnosis.
Electron beam welding of 2205 duplex stainless steel with nickel-based filler wire using multi-beam technique
Authors: Tóth Tamás , Hensel Jonas , Hesse Ann-Christin , Dilger Klaus
Published: August 2022

The duplex stainless steels have many favorable properties attributed to their two-phase microstructure consisting of almost equal fractions of ferrite and austenite. Therefore, they are widely used in the offshore, petroleum, and chemical industries as a base material for pressure vessels and pipelines. Such components often possess large thicknesses, which can be effectively welded with electron beam. This process is characterized by rapid cooling combined with a relatively great loss of nitrogen, resulting in insufficient austenite formation. To compensate this phenomenon, the addition of nickel, in the form of wire, was performed in this study. This promoted the formation of austenite at the same cooling rate, so that approximately an equal amount of ferrite and austenite was achieved. Beam oscillation was applied to maintain good dilution even at large depth/width ratios. Furthermore, the multi-beam technique was implemented to reduce the spatter formation and provide a higher process stability. This allows the spatial, but not temporal, separation of the melting-off of the wire and the main welding process. The joints produced in this way exhibit a good weld dilution and consequently an austenite distribution with a low inhomogeneity. Additionally, a narrow heat-affected zone was produced.
Indigenous Inclusion and Indigenising the University
Authors: Hoskins Te Kawehau , Jones Alison
Published: August 2022

‘Indigenous inclusion’ has been the most common approach to Māori engagement in university education in Aotearoa-New Zealand. Increasingly, another orientation, based on different premises, which might be called ‘indigenisation’, is becoming evident. We argue that indigenisation offers more hopeful possibilities for New Zealand universities as they/we continue to think about their/our obligations under Te Tiriti o Waitangi.
Analysis of ownership network of European companies using gravity models
Authors: Kosztyán Zsolt Tibor , Király Ferenc , Kurbucz Marcell T.
Published: August 2022

Social network analysis is increasingly applied to modeling regional relationships. However, in this scenario, we cannot ignore the geographical economic and technological nature of the relationships. In this study, the tools of social network analysis and the gravity model are combined. Our study is based on the Amadeus database of European organizations, which includes 24 million companies. The ownership of parent subsidiaries was modeled using economic, technological, and geographic factors. Ownership was aggregated to the NUTS 3 regional level, to which average corporate profitability indicators, the GDP per capita characterizing the economic environment, and the number of patents, which is a proxy of the technological environment, were assigned to NUTS 3 regions. The formation of the ownership network between 2010 and 2018 was characterized using this dataset. As the proposed model accurately describes the formation of ownership relationships marked with edges, it is possible to estimate network properties, such as modularity and centrality.
Advances in preparation, application in contaminant removal, and environmental risks of biochar-based catalysts: a review
Authors: Yang Bowen , Dai Jiawei , Zhao Yuan , Wu Jingwei , Ji Caiya , Zhang Yuhu
Published: August 2022

As a carbon-rich material produced by pyrolysis of biomass, biochar features low cost, large specific surface area, and widely available feedstocks based on the functional diversity and environmental-friendly properties, it has received increasing attention in the fields of pollutant removal due to three win–win effects of water remediation, carbon sequestration and reutilization of wastes. To design excellent biochar-based catalysts for environmental applications, one must understand recent advances in the catalysts for contaminant removal. This review focuses on the current application of biochar-based catalysts in redox systems, Fenton-like systems, sonocatalytic systems and photocatalytic systems. Besides in-depth discussion in effects of preparation conditions on physicochemical characteristics of biochars, the review supplements new preparation technologies of biochar and biochar-based catalysts. Most importantly, the advantages/shortcomings, catalysis mechanisms, as well as the pollutant removal ability of different types of biochar-based catalysts are discussed. The environmental risks of the catalyst applications are also elaborated on. Future research on biochar-based catalyst production and its environmental applications is discussed. The review provides a good overview of the current advances of biochar-based catalysts in pollutant control and the futureresearch directions.

Graphical Abstract
Bird species composition, density and feeding guilds in contrasting lowland dipterocarp forests of Terengganu, Peninsular Malaysia
Authors: Shafie Nur Juliani , Anuar Habibah , David Gertrude , Ahmad Amirrudin , Abdullah Mohd Tajuddin
Published: August 2022

A study was conducted to determine the species composition, density and feeding guild of birds at Tasik Kenyir and Setiu, Terengganu between June and September 2017 using line transect method. Observations of birds at Tasik Kenyir and Setiu recorded a total of 297 individuals consisting of 26 families from 64 species. This study estimated that the diversity of birds at Tasik Kenyir (H’ = 3.6) was higher compared to Setiu (H’ = 2.9). However, the density of birds at Setiu (52.05 ± 9.09 SE individuals/ha) was higher than Tasik Kenyir (37.56 ± 10.28 SE individuals/ha). Ten feeding guilds of birds were identified in this study; insectivore, nectarivore, frugivore, omnivore, carnivore, granivore, insectivore-nectarivore, insectivore-frugivore, insectivore-granivore and frugivore-granivore. This study has provided valuable information on the bird assemblage and the understanding on the distribution of birds at Tasik Kenyir and Setiu. It is highly recommended that further studies to be conducted at both sites with more sampling efforts in order to gain a more comprehensive baseline datasets for monitoring bird population trends and turnover between habitats.
The Post-Partisans
Authors: Meléndez Carlos
Published: August 2022

Where party identification is in decay or in flux, alternative political identifications have gained centrality. In this Element, the author develops a typology of post-partisan political identities: alternative ways in which rejection of or the absence of partisan politics are defining political identifiers or non-identifiers. Based on original evidence collected through opinion polls in different Latin American countries, as well as applying an innovative measurement, the author shows the respective magnitudes and ideological composition of anti-partisans (individuals who hold negative partisanships: strong identities based on predispositions against a specific political party or movement), anti-establishment identifiers (individuals who hold many negative partisanships simultaneously), and apartisans (individuals who lack any positive or negative partisanships). This Element demonstrates the usefulness of employing these categories in order to better understand different levels of party system institutionalization, party-building, and partisan polarization in the region.
Safety-II: Building safety capacity and aeronautical decision-making skills to commit better mistakes
Authors: Lima Brugnara R. , de Andrade D. , de Souza Fontes R. , Soares Leão M.
Published: August 2022

Problem: Why did the pilots do that? Human error is a reasonably common retrospective assignment of responsibility tied to undesirable aeronautical safety occurrences. Although retributive justice has long been accepted in aviation, its effectiveness in preventing recurrence is minimal. Airmen tend to decide based on their best knowledge with the available resources in intrinsically fallible systems in the ultra-safe high-risk aviation industry.

Method and Results: This paper sheds light on Safety as Capacity under the vanguardist Safety-II perspective and examines procedures as static tools incapable of sustaining safety. It discusses the prejudice in non-critical adherence to procedural compliance beyond creating bureaucratic work environments permissible to sanction workers against regulations. Disputing the safety gain in a retrospective analysis of mishaps, the paper instils the airmen as solution elements to sustain safety at the management of context, a fundamental aspect of Safety-II.

Impact on Industry: A systemic deficiency in civilian pilot training is exposed, and an independent organisational Safety Capacity assessment tool to air operations is provided. The main debate is the synergetic interaction between aircrew’s aeronautical decision-making skills and organisational Safety-II as safety capacity. The pilot’s preparedness to analyse, create and evaluate outside forecasted protocols in modern aviation environments is discussed. These dynamics are revised in their inter-reliability known as Safety as Capacity.
What determines women's labor supply? The role of home productivity and social norms
Authors: Afridi Farzana , Bishnu Monisankar , Mahajan Kanika
Published: August 2022

We highlight the role of home productivity and social norms in explaining the gender gap in labor force participation (LFP), and the non-monotonic relationship of women's LFP with their education in India. We construct a model of couples’ time allocation decisions allowing for both market and home productivity to improve with own education. Incorporating individual preference to produce a minimum level of the home good due to social norms, we show that our theoretical model can closely replicate the U-shaped relationship between women's education and their labor supply. Our analysis suggests that home productivity, along with social benchmarks on couples’ time allocation to home good, can be critical determinants of women's labor supply in developing countries.
Validation of the Thumbs food classification system as a tool to accurately identify the healthiness of foods
Authors: Chan Jasmine , McMahon Emma , Wycherley Thomas , Howes Kylie , Bidstrup Graham , Brimblecombe Julie
Published: August 2022

The Thumbs food classification system was developed to assist remote Australian communities to identify food healthiness. This study aimed to assess: (1) the Thumbs system’s alignment to two other food classification systems, the Health Star Rating (HSR) and the Northern Territory School Canteens Guidelines (NTSCG); (2) its accuracy in classifying ‘unhealthy’ (contributing to discretionary energy and added sugars) and ‘healthy’ products against HSR and NTSCG; (3) areas for optimisation. Food and beverage products sold between 05/2018 and 05/2019 in fifty-one remote stores were classified in each system. System alignment was assessed by cross-tabulating percentages of products, discretionary energy and added sugars sold assigned to the same healthiness levels across the systems. The system/s capturing the highest percentage of discretionary energy and added sugars sold in ‘unhealthy’ products and the lowest levels in ‘healthy’ products were considered the best performing. Cohen’s κ was used to assess agreement between the Thumbs system and the NTSCG for classifying products as healthy. The Thumbs system classified product healthiness in line with the HSR and NTSCG, with Cohen’s κ showing moderate agreement between the Thumbs system and the NTSCG (κ = 0·60). The Thumbs system captured the most discretionary energy sold (92·2 %) and added sugar sold (90·6 %) in unhealthy products and the least discretionary energy sold (0 %) in healthy products. Modifications to optimise the Thumbs system include aligning several food categories to the NTSCG criteria and addressing core/discretionary classification discrepancies of fruit juice/drinks. The Thumbs system offers a classification algorithm that could strengthen the HSR system.
Rethinking Monetary Sovereignty: The Global Credit Money System and the State
Authors: Murau Steffen , van ’t Klooster Jens
Published: August 2022

We propose a new conception of monetary sovereignty that acknowledges the reality of today’s global credit money system. Today, the concept is predominantly used to denote states that issue and regulate their own currency. We reject that Westphalian understanding of monetary sovereignty. Instead, we propose a conception of effective monetary sovereignty that focuses on what states are actually able to do in the era of financial globalization. The conception fits the hybridity of the modern credit money system by acknowledging the crucial role not only of central bank money but also of money issued by regulated banks and unregulated shadow banks. These institutions often operate “offshore”, outside of a state’s legal jurisdiction, which makes monetary governance more difficult. Monetary sovereignty consists in the ability of states to effectively govern these different segments of the monetary system and thereby achieve their economic policy objectives.