bluuebunny/crossref_metadata_2025 huggingface dataset:
THE USE OF ANYLOGIC SYSTEM FOR MODELLING A FLEXIBLE AUTOMATED PACKING SYSTEM IN TRAINING ENGINEERING STUDENTS
Authors: Пальчевський Богдан Олексійович , Крестьянполь Олена Анатоліївна , Крестьянполь Любов Юріївна
Published: February 2020

The authors have considered possibilities of organizing the training of students majoring in engineering specialty “131. Applied Mechanics” in the course “CAD of packaging production” using the specialized software of the AnyLogic Company.

The paper presents software products for automated calculation and modeling of the technological process of packaging. As a result of studying the software product, the students will be able to master the techniques of automated calculation and design of packaging components and implement projects using modern CAD and CAM systems.

The purpose of modeling the technological processes of packaging is to increase their productivity by determining and justifying the optimal parameters. The study of technological processes based on simulation modeling allows the students to identify interconnections, to highlight technical and economic indicators, to evaluate the impact on profitability, to determine the directions of development and ways to improve the technical and technological facilities.

The methodology for developing a flexible automated line simulation model, for example, for the production of macaroni products, is described in this work. Authors highlighted the stages of modelling a flexible automated packaging system.

The criteria that influence the technological process of bulk products packing are determined. The parameters for constructing the simulation model are selected. A formal description of the packing line has been made for a more detailed understanding of the process and the adequate construction of the model. With the help of the software of The AnyLogic Company, students create an acting part of the model, simulate processing at workshops and the work of a warehouse.

As a result, in the developed simulation model, the authors researched the load of the production elements, determined problematic structural elements and calculated the coefficient of the technological line readiness. The virtual model of the technological line allowed testing the future technological line for adequacy, process ability and reliability.

As a result of studying the discipline "CAD of packaging production" and AnyLogic software, students develop holistic understanding of the automated process and acquire the skills of modeling, analysis and optimization of the technological line.
МОБІЛЬНІ ТЕХНОЛОГІЇ НАВЧАННЯ У ПРОФЕСІЙНІЙ ПІДГОТОВЦІ МАЙБУТНІХ ФАХІВЦІВ МОРСЬКОГО ТРАНСПОРТУ
Authors: Волошинов Сергій Анатолійович
Published: February 2020

Стаття окреслює сучасну проблему вдосконалення професійної підготовки майбутніх фахівців річкового та морського транспорту засобами сучасних мобільних технологій. Автор з метою з’ясування можливостей і перспектив мобільного навчання в процесі професійної підготовки майбутніх фахівців морського транспорту здійснив аналіз мобільних програм у магазинах додатків для платформ Google Android, Apple iOS та Windows Mobile. У процесі дослідження з’ясовано, що в магазинах мобільних додатків Google play, App Store та Microsoft Store наявні програми для моряків та ті, що можна використовувати в їх професійній підготовці в освітніх цілях. Відповідно до їх призначення ці програми розподілено на такі групи: додатки для вивчення іноземної мови, довідники та словники для моряків, тренажери для проходження професійних тестів, програми для пошуку вакансій та персоналу в морській галузі, навігаційні програми та карти, електронні вахтові журнали, записні книжки та планувальники для моряків, керівництва для моряків, програми для контролю за здоров’ям моряків, імітації вимірювальних морських приладів, додатки для прогнозу погоди, факсимільні карти для моряків про вітер, хвилі, погоду і припливи. Проаналізовано можливості використання датчиків смартфонів для фіксації часу руху та інтервалів часу для контролю послідовності подій чи процесів, для вимірювання різних параметрів навколишнього середовища, для дослідження параметрів світла, звуку, прискорення, атмосферного тиску тощо. На основі аналізу мобільних додатків та опитування студентів Херсонської державної морської академії щодо використання мобільних пристроїв у навчанні зроблено висновок про те, що програми магазину Google Play мають багато можливостей для їх використання в процесі професійної підготовки майбутніх фахівців морського транспорту через їх велику різноманітність, безкоштовність та зручність самого магазину додатків.
USE OF IT FOR FUTURE FOREIGN LANGUAGE TEACHERS’ LINGUISTIC SELF-EDUCATION
Authors: Шумський Олександр Леонідович
Published: February 2020

The article substantiates that large-scale implementation of information technologies will facilitate methodological support of future foreign language teachers’ linguistic self-education.

The main functions and advantages of the author’s multimedia training package “English for Self-Education”, designed to support future foreign language teachers’ linguistic self-educational activities, are characterized. It is defined that the package is an open-ended multipurpose programmatic learning system, containing didactic, methodological, informational and reference materials. The package is based on general pedagogical, ergonomic and specific principles of informatization of education.

It has a dual structure, which includes two levels. The first level contains 1) lexical-informational component that provides working with lexical and theoretical material, 2) training element, which enables practicing knowledge and skills, as well as mastering methods and means of autonomous managing, regulating and correcting the process of linguistic self-education, 3) control aspect, which allows realizing independent monitoring and evaluating the degree and quality of acquired knowledge and skills. The second level considerably extends didactic possibilities and educational resources of the package. It covers a wide range of extra learning materials of theoretical and practical nature that are available both in the package itself and beyond its limits through providing the access to the “virtual reality” within external resources of global network. All the above not only makes for activating students’ cognitive activity but also significantly enriches their language and sociocultural practice.

The package enables comprehensive independent study of a foreign language, exercising self-diagnostics in order to detect gaps in the student’s foreign-language competence, performing intensive linguistic self-educational activities, constant monitoring the level of autonomously mastered foreign-language material, carrying out search for information, etc.

Thus, the package provides optimal conditions for future foreign language teachers’ linguistic self-educational activities. Students have an opportunity to actualize the adaptive algorithm of building the individual trajectory of linguistic self-education in accordance with their psychological features and personal educational needs.

It is shown that working with the package results in students’ receiving an external and internal educational products, namely improving foreign-language knowledge and skills, along with gaining personal experience of linguistic self-educational activities.

It is grounded by the example of the proposed package that comprehensive use of IT significantly optimizes the process of linguistic self-education.
EDUCATIONAL CONDITIONS FOR IMPLEMENTATION OF ADULTS’ DISTANCE LEARNING OF FOREIGN LANGUAGES
Authors: Вікторова Леся Вікторівна
Published: February 2020

In the paper the results of the experimental study of the adult distance learning management are suggested. The urgency of the research is based on the tendency towards the aging of population, development of the third age universities network, active implementation of the lifelong learning philosophy, the analysis of recent publications and studies. It is determined that despite the growing popularity of the lifelong learning philosophy, there is a lack of systematic research on the use of ICT for the elderly. In the paper the historical essay on the problems of distance learning for the elderly is offered. The conceptual framework is analyzed. The methodology of the research and features of the target audience selection are described; the specifics of data collection and analysis at different stages of the research are defined. The purpose of the research is determined – to distinguish pedagogical conditions for an effective distance learning introduction into foreign language education of the elderly. The research has been conducted on the basis of the Center for Innovative Education. The emphasis is made on the formation of the target group of participants in the study and their foreign language learning motivation. The stages of data collection and analysis are specified, namely: before the beginning of training, at the stage of the curriculum development, after the start of the first module of the distance learning course, after the completion of the first module of the course, at the end of the course and two months after the course is completed. Detailed results of data analysis for each stage of the research are delivered. The analysis of these data is carried out. The features of the distance course for the elderly and the methodological recommendations on its development are defined. The study has also allowed to confirm the results of the personal and cognitive potential of the elderly and revealed that the ability to learn under certain conditions even increases instead of decreasing. The prospects for further research, adjacent to neurophysiologists’ and neurobiologists’ studies, are suggested. The aforementioned prospects raise the issue of the further scenarios for the use of distance learning platforms for the elderly.
MASSIVE OPEN ONLINE COURSES AS A MEANS OF BORDER GUARDS’ PROFESSIONAL COMPETENCE DEVELOPMENT
Authors: Лемешко Ольга Василівна , Янковець Олена Володимирівна , Лемешко Володимир Володимирович , Янковець Андрій Володимирович , Басараба Ірина Олегівна
Published: February 2020

Massive open online courses (MOOCs) have attracted a great deal of interest in recent years as a modern learning technology. This paper examines the issue of developing professional competencies in further training of border guards through MOOCs. Mobile learning, distance education, use of the information technologies have been differentiated. The preparation for life-long learning is especially important for border guards due to the rapid development of the information technology. Further education helps them counter threats to national security, conflicts and non-standard situations at the border crossing points, and new methods violators use to forge documents, to smuggle goods and to cross the state border. The use of MOOCs for advanced training in the State Border Guard Service of Ukraine has been analyzed. The purpose of the article is to analyze the application of MOOCs for developing professional competencies of border guards. Each MOOC is aimed at developing the Integral competence, General competencies and Professional (special) competencies of border guard officers. The ability to communicate in English is one of the special competencies of border guards, and it is essential for effective protection of the state border. The peculiarities of development of MOOC “Conducting the second line check at border crossing points” for training of border guards who serve in the border guard units and want to be promoted to higher positions have been investigated. The experiment was carried out at the Bohdan Khmelnytskyi National Academy of the State Border Guard Service of Ukraine and involved 276 border guards. The analysis of the results of the developed distance course testified its effectiveness. The generalization of feedback from the participants in this course also indicated an increase in the motivation of border guards to develop personal professional skills, especially for communication in a foreign language. The results of the study have been further discussed and the practical suggestions for MOOC developers have been outlined.
ТЕХНОЛОГІЯ ФОРМУВАННЯ ЦИФРОВОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ УЧИТЕЛІВ ЗАСОБАМИ ГЕЙМІФІКАЦІЇ
Authors: Жерновникова Оксана Анатоліївна , Перетяга Людмила Євгенівна , Ковтун Анна Володимирівна , Кордубан Марина Валеріївна , Наливайко Олексій Олексійович , Наливайко Наталія Анатоліївна
Published: February 2020

У статті проведено науковий аналіз суті понять «цифрова підготовка майбутнього педагога», «цифрова компетентність», «гейміфікація освіти». Доведено, що одним із чинників, які сприяють ефективному розвитку освітнього процесу сучасного закладу вищої освіти, є формування цифрової компетентності майбутніх учителів засобами гейміфікації, оскільки в освіті переважає нова ідеологія, заснована на «гейміфікації» та «діджіталізаціі» освіти, де на зміну традиційним педагогам приходять «ігропедагоги», «координатори онлайн-платформ і освітніх траєкторій». Визначено, що результатом формування цифрової підготовки майбутніх учителів є сформована цифрова компетентність, складником якої є мотиваційно-ціннісний, когнітивний, операційний компоненти. Для перевірки сформованості цифрової компетентності майбутніх учителів засобами гейміфікації за визначеними критеріями (мотиваційний, когнітивний, рефлексивно-коригувальний) описано методи дослідження. Результати проведеного анкетування, тестування й опитування дали підстави констатувати переважно середній та низький рівні сформованості цифрової компетентності майбутніх учителів засобами гейміфікації. На основі отриманих результатів теоретично обґрунтовано та розроблено технологію формування цифрової компетентності майбутніх учителів засобами гейміфікації, яку реалізовано на таких етапах: професійно-мотиваційний, змістово-діяльнісний, рефлексійно-корегувальний. Розроблену технологію було реалізовано за таких умов: інтеграція засобів гейміфікації в процес підготовки майбутніх учителів під час опрацювання навчальної інформації; застосування організаційно-технічних заходів і методів забезпечення інформаційної безпеки при роботі з цифровими освітніми технологіями; відбір найбільш ефективних цифрових освітніх технологій; застосування освітніх платформ для розроблення цифрових навчальних проэктів. У статті засобами гейміфікації, які були спрямовані на формування цифрової компетентності майбутніх учителів, було обрано такі мобільні додатки, які використовуються в освітньому процесі: DuoLingo, ClassDojo, Coursera, Brainscape, Socrative 101. Експериментальне впровадження розробленої технології вказує на позитивні результати сформованості цифрової компетентності майбутніх учителів засобами гейміфікації.
ФОРМУВАННЯ КОГНІТИВНОЇ СКЛАДОВОЇ ПРОФЕСІЙНО-КОМУНІКАТИВНОЇ КУЛЬТУРИ МАЙБУТНІХ СІМЕЙНИХ ЛІКАРІВ ЗАСОБАМИ ІНФОРМАЦІЙНО-ОСВІТНЬОГО БЛОГУ
Authors: Акімова Ольга Вікторівна , Дудікова Лариса Володимирівна , Коломієць Алла Миколаївна , Остраус Юлія Михайлівна
Published: February 2020

У статті підкреслено актуальність проблеми формування професійно-комунікативної культури майбутніх сімейних лікарів у процесі їх підготовки у вищих медичних навчальних закладах, обґрунтовано необхідність застосування блог-технології з метою забезпечення її когнітивної складової. Висвітлено практичні аспекти створення інформаційно-освітнього блогу викладача, що має на меті вдосконалення професійно-комунікативної культури студентів-медиків. Визначено етапи розробки блогу, його цілі та функції, розроблено структуру. Окреслено можливості системи керування контентом WordPress, яку було обрано в якості платформи блогу. Висвітлено властивості «кліпового мислення» сучасної молоді, що сформувалося в умовах новітнього інформаційного середовища завдяки масовому поширенню мобільних телефонів та Інтернету. Відповідно до окреслених психологічних особливостей визначено вимоги до змістової складової матеріалу блогу та формату її викладення, а саме: подання інформації у вигляді кліпів; застосування яскравих наочних презентацій зі зрозумілими та образними формулюваннями; використання образів, що можуть мати вигляд слайдів чи анімаційних відео. Виділено критерії відбору текстових та відеоматеріалів для блогу. Висвітлено мету кожного з розділів блогу, принципи відбору й розробки матеріалів блогу, коротко окреслено його зміст. Розглянуто особливості та переваги інтерактивних онлайн вправ,  створених у середовищі LearningApps.org. Підкреслено доцільність застосування онлайн вправ з метою збільшення лексичного запасу англійської медичної термінології. Запропоновано завдання для роботи студентів з блогом на заняттях з іноземної мови, організованих за принципами  сучасного освітнього тренду BYOD. Практичним результатом проведеного дослідження є створений нами інформаційно-освітній блог викладача «Doctor-Patient Communication».
EXPERIENCE OF ICT IMPLEMENTATION IN PRIMARY CURRICULUM IN UKRAINE AND THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND
Authors: Борисенко Ірина Василівна , Биконя Оксана Павлівна , Рембач Ольга Олександрівна , Шумна Лариса Петрівна , Олійник Олександр Іванович , Аніщенко Вікторія Олександрівна
Published: February 2020

The study was formulated within the context of an increasing recognition of ICT as curriculum priorities in primary schools of many European countries. The implementation of ICT-centered curriculum is a step towards realizing the goals of the new Law of Ukraine “On Education” (2017), National Strategy for the Development of Education in Ukraine until 2021, European strategic programme “Education and Training 2020”. Actuality of approaches to ICT implementation in present-day primary schools is caused by the substantial development of digital technologies and requirement of digital literacy for people’s work, social, and personal lives. The unique opportunity of primary education as a large sub-sector of any education system is to contribute to the renewal of societies through education of the young. The paper aims to study implementation of Computer science into national standard of primary education in Ukraine and the UK. In the recent years, many European countries have seen some changes of the content one of which relates to the area of computer science education that resulted in implementing an ambitious new curriculum in this subject. The author gives a comparative analysis of primary ICT within national standards in term of the Computer science development from the initial stage to present day situation. The comparative analysis specifies areas of similarities (aims, objectives, approaches to implementation, priorities of developing digital skills, teaching hours) and differences (programme topics, characterization of learning outcomes) in the study of ICT covering the subject content, expected learning results and general principles of ICT in education, as well as examples of ICT implementation.
The paper is also focused at discussing the role of the ICT curriculum in modern-day primary classroom; advantages and disadvantages of ICT integration at primary stage.
Much attention is paid to how it is integrated into daily learning modes to allow and encourage active learning. In primary education there are two main models of ICT implementation into curriculum, these are: ICT integrated across the curriculum; ICT (or Informatics, Computer Science and Computing) as a discrete subject within national standard.
DESIGN OF THE EDUCATIONAL ENVIRONMENT FOR STEM-ORIENTED LEARNING
Authors: Осадчий В’ячеслав Володимирович , Валько Наталія Валеріївна , Кушнір Наталія Олександрівна
Published: February 2020

The article examines the impact of market requirements on the educational system, technological development of society and changes in the economic development of the country. The main directions of changes in European educational policy and their formalization in the framework of competences have been reviewed. The considered practices of organizing educational space in Ukraine and other countries allowed determining the structure of the interaction of participants in the educational environment of STEM-oriented training: administrative and managerial component, cooperation between education and business structures, scientific and methodological support, technological factor, popularization and human factor. The article gives a definition of the educational environment of STEM-oriented learning. According to each of the points of this structure, the peculiarities of their implementation in Ukraine have been presented: steps to implementation at legislative level have been taken, a list of measures aimed at popularizing and supporting STEM-education has been developed, a way of the dissemination of these ideas has been outlined and the list of already existing developments and implementation practices has been made. The conditions required for the development of educational STEM-environment have been defined. The article presents the model of the educational environment of STEM-oriented learning developed at the STEM-school of Kherson State University. The description of the project activity of the teacher and students in the context of the creation of educational environment of STEM-oriented learning is given. Also, the article offers examples of interdisciplinary projects. Their implementation requires that the teacher have a good theoretical foundation in mathematics, physics, technology and programming.
ФОРМУВАННЯ ІНФОРМАЦІЙНОЇ КУЛЬТУРИ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВОЇ ШКОЛИ ЗАСОБАМИ ІНФОРМАЦІЙНО-КОМУНІКАЦІЙНИХ ТЕХНОЛОГІЙ
Authors: Олійник Віктор Васильович , Андрощук Ірина Миколаївна , Остапйовська Ірина Ігорівна , Олешко Петро Степанович , Пріма Дмитро Анатолійович
Published: February 2020

У статті описано формування інформаційної культури майбутніх учителів початкової школи засобами інформаційно-комунікаційних технологій. Виділено та описано чотири компоненти інформаційної культури вчителя початкової школи: когнітивна (передбачає знання про інформаційне суспільство на глобальному та локальному рівнях і основні його тенденції), операційно-змістова (передбачає вміння використовувати інформаційно-комунікаційні технології для вирішення різноманітних практичних проблем як особистісних, так і суспільного значення), комунікативна (передбачає знання норм культури поведінки та спілкування з використанням інформаційно-комунікаційних технологій та дотримання їх), ціннісно-рефлексивна (передбачає критичне ставлення до контенту інформаційних ресурсів, нерозповсюдження та запобігання поширенню дезінформації та інформації аморального, протиправного змісту, дотримання інформаційного законодавства, запобігання комп’ютерній залежності), що лягли в основу розроблення курсу «Культура інформаційної діяльності у початковій школі» для здобувачів вищої освіти Східноєвропейського національного університету імені Лесі Українки спеціальності 013 Початкова освіта спеціалізації «Інформатика». Виділено та описано ключові аспекти для ефективного використання інформаційно-комунікаційних технологій у майбутній професійній діяльності, проілюстровано результати впровадження зазначеного курсу. Аналіз дослідження засвідчує приріст у відсотковому відношенні високого і достатнього рівнів інформаційної культури майбутніх учителів початкової школи. Упровадження розробленого курсу засвідчує, що після його завершення показники високого рівня сформованості інформаційної культури становили на 12,5% більше, ніж на початку експерименту, на достатньому – збільшились на 27,5 %, показники середнього і низького рівнів після завершення експерименту зменшились. Визначено прогностичність досліджуваної проблеми, що полягає в міждисциплінарності розробленого курсу і використанні його науково-педагогічними працівниками в процесі підготовки здобувачів вищої освіти в різних освітніх галузях.
ПРЕЗЕНТАЦІЯ ВІЗУАЛЬНОЇ ГРАМОТНОСТІ В ОСВІТНЬОМУ ПРОЦЕСІ ТА ЇЇ ЕКСПЛІКАЦІЯ В КУЛЬТУРІ МИСЛЕННЯ
Authors: Кремень Василь Григорович , Ільїн Володимир Васильович
Published: February 2020

У статті висвітлюється креативність і особливості застосування візуальної грамотності, що набула актуальності в епоху розвитку інформаційно-комп’ютерних технологій, упровадження яких в освіту підносить її на рівень сучасних вимог. Здійснено аналіз «візуального повороту», у результаті якого виникла візуальна культура. У її контексті набув розвитку комплекс наукових розвідок щодо проблеми візуальності, розв’язання якої формує способи обробки візуальної інформації, використання візуального сприйняття в освітніх процесах і комунікації, а також технік аргументації на основі візуальної інформації. Підкреслюється вплив візуалізації на освіту, в основі якої тепер лежить не тільки мова, а й мультимедійна екранна комунікація, що формує сучасну грамотність. Зазначається, що грамотність ХХІ століття мультимодальна, здатна до швидкої та творчої інтерпретації, означає навчання з власними правилами конструювання, спрямована на інтерактивні комунікації в режимі реального часу, передбачає можливість використання медіа для виклику емоційних реакцій, має потенціал зміни способів, методів, технологій, форм навчання. Вказуються ключові академічні досягнення сучасності: грамотність цифрової доби; базова, наукова, економічна, технологічна, візуальна, інформаційна, мультикультурна грамотність і глобальна обізнаність; винахідницьке мислення; ефективна комунікація; висока продуктивність. Виявлено, що під візуальною грамотністю розуміємо здатність сприймати та використовувати візуальні образи, разом із здатністю індивіда мислити, вчитися і виражати думки в зображеннях. Це означає сприйняття логіки, емоцій і смислів, які наявні у візуальній інформації, а також здатність продукувати образи в комунікації. Зазначається, що візуально грамотні учні та студенти мають практичні знання зі створення та відтворення візуальної інформації в цифрових медіа, а також постають продуктивними візуальними комунікаторами, які мислять відповідно до запитів цифрової реальності. Зазначається, що візуальна спрямованість сучасних освітніх практик обумовлена розвитком інформаційно-комп’ютерних технологій, які породжують екранно-образну реальність.
Lack of Reactive Oxygen Species Deteriorates Blood Pressure Regulation in Acute Stress
Authors: BERNÁTOVÁ I. , BALIŠ P. , GOGA R. , BEHULIAK M. , ZICHA J. , SEKAJ I.
Published: February 2020

This study investigated the contribution of reactive oxygen species (ROS) to blood pressure regulation in conscious adult male Wistar rats exposed to acute stress. Role of ROS was investigated in rats with temporally impaired principal blood pressure regulation systems using ganglionic blocker pentolinium (P, 5 mg/kg), angiotensin converting enzyme inhibitor captopril (C, 10 mg/kg), nitric oxide synthase inhibitor L-NAME (L, 30 mg/kg) and superoxide dismutase mimeticum tempol (T, 25 mg/kg). Mean arterial pressure (MAP) was measured by the carotid artery catheter and inhibitors were administered intravenously. MAP was disturbed by a 3-s air jet, which increased MAP by 35.2±3.0 % vs. basal MAP after the first exposure. Air jet increased MAP in captopril- and tempol-treated rats similarly as observed in saline-treated rats. In pentolinium-treated rats stress significantly decreased MAP vs. pre-stress value. In L-NAME-treated rats stress failed to affect MAP significantly. Treatment of rats with P+L+C resulted in stress-induced MAP decrease by 17.3±1.3 % vs. pre-stress value and settling time (20.1±4.2 s). In P+L+C+T-treated rats stress led to maximal MAP decrease by 26.4±2.2 % (p<0.005 vs. P+L+C) and prolongation of settling time to 32.6±3.3 s (p<0.05 vs. P+L+C). Area under the MAP curve was significantly smaller in P+L+C-treated rats compared to P+L+C+T-treated ones (167±43 vs. 433±69 a.u., p<0.008). In conclusion, in rats with temporally impaired blood pressure regulation, the lack of ROS resulted in greater stress-induced MAP alterations and prolongation of time required to reach new post-stress steady state.
Interaction of Perivascular Adipose Tissue and Sympathetic Nerves in Arteries From Normotensive and Hypertensive Rats
Authors: TÖRÖK J. , ZEMANČÍKOVÁ A. , KOCIANOVÁ Z.
Published: February 2020

The inhibitory action of perivascular adipose tissue (PVAT) in modulation of arterial contraction has been recently recognized and contrasted with the prohypertensive effect of obesity in humans. In this study we demonstrated that PVAT might have opposing effect on sympatho-adrenergic contractions in different rat conduit arteries. In superior mesenteric artery isolated from normotensive Wistar-Kyoto rats (WKY), PVAT exhibited inhibitory influence on the contractions to exogenous noradrenaline as well as to endogenous noradrenaline released from arterial sympathetic nerves during transmural electrical stimulation or after application of tyramine. In contrast, the abdominal aorta with intact PVAT responded with larger contractions to transmural electrical stimulation and tyramine when compared to the aorta after removing PVAT; the responses to noradrenaline were similar in both. This indicates that PVAT may contain additional sources of endogenous noradrenaline which could be responsible for the main difference in the modulatory effect of PVAT on adrenergic contractions between abdominal aortas and superior mesenteric arteries. In spontaneously hypertensive rats (SHR), the anticontractile effect of PVAT in mesenteric arteries was reduced, and the removal of PVAT completely eliminated the difference in the dose-response curves to exogenous noradrenaline between SHR and WKY. These results suggest that in mesenteric artery isolated from SHR, the impaired anticontractile influence of PVAT might significantly contribute to its increased sensitivity to adrenergic stimuli.
Effect of Melatonin on Blood Pressure and Nitric Oxide Generation in Rats With Metabolic Syndrome
Authors: KLIMENTOVA J. , CEBOVA M. , BARTA A. , MATUSKOVA Z. , VRANKOVA S. , REHAKOVA R. , KOVACSOVA M. , PECHANOVA O.
Published: February 2020

Melatonin, a multitasking indolamine, seems to be involved in a variety of physiological and metabolic processes via both receptor-mediated and receptor-independent mechanisms. The aim of our study was to find out whether melatonin can affect blood pressure (BP), nitric oxide synthase (NOS) activity, eNOS and nNOS protein expressions in rats with metabolic syndrome (SHR/cp). Rats were divided into four groups: 6-week-old male WKY andSHR/cp and age-matched WKY and SHR/cp treated with melatonin (10 mg/kg/day) for 3 weeks. BP was measured by tail-cuff plethysmography. NOS activity, eNOS and nNOS protein expressions were determined in the heart, aorta, brain cortex and cerebellum. MT1 receptors were analyzed in the brain cortex and cerebellum. In SHR/cp rats, BP was decreased after melatonin treatment. In the same group, melatonin did not affect NOS activity and eNOS protein expression in the heart and aorta, while it increased both parameters in the brain cortex and cerebellum. Interestingly, melatonin elevated MT1 protein expression in the cerebellum. Neuronal NOS protein expression was not changed within the groups. In conclusion, increased NOS activity/eNOS upregulation in particular brain regions may contribute partially to BP decrease in SHR/cp rats after melatonin treatment. Participation of MT1 receptors in this melatonin action may be supposed.
The Role of PPARγ in Cardiovascular Diseases
Authors: KVANDOVÁ M. , MAJZÚNOVÁ M. , DOVINOVÁ I.
Published: February 2020

The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of ligand-activated transcription factors. PPARγ acts as a nutrient sensor that regulates several homeostatic functions. Its disruption can lead to vascular pathologies, disorders of fatty acid/lipid metabolism and insulin resistance. PPARγ can modulate several signaling pathways connected with blood pressure regulation. Firstly, it affects the insulin signaling pathway and endothelial dysfunction by modulation of expression and/or phosphorylation of signaling molecules through the PI3K/Akt/eNOS or MAPK/ET-1 pathways. Secondly, it can modulate gene expression of the renin- angiotensin system – cascade proteins, which potentially slow down the progression of atherosclerosis and hypertension. Thirdly, it can modulate oxidative stress response either directly through PPAR or indirectly through Nrf2 activation. In this context, activation and functioning of PPARγ is very important in the regulation of several disorders such as diabetes mellitus, hypertension and/or metabolic syndrome.
Effect of Deuterium-Depleted Water on Selected Cardiometabolic Parameters in Fructose-Treated Rats
Authors: REHAKOVA R. , KLIMENTOVA J. , CEBOVA M. , BARTA A. , MATUSKOVA Z. , LABAS P. , PECHANOVA O.
Published: February 2020

Deuterium-depleted water (DDW) has a lower concentration of deuterium than occurs naturally (less than 145 ppm). While effects of DDW on cancer started to be intensively studied, the effects on cardiovascular system are completely unknown. Thus, we aimed to analyze the effects of DDW (55±5 ppm) administration to 12-week-old normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) treated with 15 % fructose for 6 weeks. Blood pressure (BP) and selected biochemical parameters were measured together with determination of nitric oxide synthase (NOS) activity and iNOS and eNOS protein expressions in the left ventricle (LV) and aorta. Neither DDW nor fructose had any significant effect on BP in both strains. DDW treatment decreased total cholesterol and triglyceride levels in WKY, but it was not able to prevent increase in the same parameters elevated due to fructose treatment in SHR. Both fructose and DDW increased insulin level in WKY. Fructose did not affect NOS activity either in WKY or SHR. DDW increased NOS activity in LV of both WKY and SHR, while it decreased NOS activity and iNOS expression in the aorta of SHR with or without fructose treatment. In conclusion, DDW treatment significantly modified biochemical parameters in WKY together with NOS activity elevation in the heart. On the other hand, it did not affect biochemical parameters in SHR, but decreased NOS activity elevated due to iNOS upregulation in the aorta.
Cardiovascular Effects of Gasotransmitter Donors
Authors: CEBOVÁ M. , KOŠÚTOVÁ M. , PECHÁŇOVÁ O.
Published: February 2020

Gasotransmitters represent a subfamily of the endogenous gaseous signaling molecules that include nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H2S). These particular gases share many common features in their production and function, but they fulfill their physiological tasks in unique ways that differ from those of classical signaling molecules found in tissues and organs. These gasotransmitters may antagonize or potentiate each other’s cellular effects at the level of their production, their downstream molecular targets and their direct interactions. All three gasotransmitters induce vasodilatation, inhibit apoptosis directly or by increasing the expression of anti-apoptotic genes, and activate antioxidants while inhibiting inflammatory actions. NO and CO may concomitantly participate in vasorelaxation, anti-inflammation and angiogenesis. NO and H2S collaborate in the regulation of vascular tone. Finally, H2S may upregulate the heme oxygenase/carbon monoxide (HO/CO) pathway during hypoxic conditions. All three gasotransmitters are produced by specific enzymes in different cell types that include cardiomyocytes, endothelial cells and smooth muscle cells. As translational research on gasotransmitters has exploded over the past years, drugs that alter the production/levels of the gasotransmitters themselves or modulate their signaling pathways are now being developed. This review is focused on the cardiovascular effects of NO, CO, and H2S. Moreover, their donors as drug targeting the cardiovascular system are briefly described.
Blood Pressure Regulation in Stress: Focus on Nitric Oxide-Dependent Mechanisms
Authors: PUZSEROVA A. , BERNATOVA I.
Published: February 2020

Stress is considered a risk factor associated with the development of various civilization diseases including cardiovascular diseases, malignant tumors and mental disorders. Research investigating mechanisms involved in stress-induced hypertension have attracted much attention of physicians and researchers, however, there are still ambiguous results concerning a causal relationship between stress and long-term elevation of blood pressure (BP). Several studies have observed that mechanisms involved in the development of stress-induced hypertension include increased activity of sympathetic nervous system (SNS), glucocorticoid (GC) overload and altered endothelial function including decreased nitric oxide (NO) bioavailability. Nitric oxide is well known neurotransmitter, neuromodulator and vasodilator involved in regulation of neuroendocrine mechanisms and cardiovascular responses to stressors. Thus NO plays a crucial role in the regulation of the stress systems and thereby in the BP regulation in stress. Elevated NO synthesis, especially in the initial phase of stress, may be considered a stress-limiting mechanism, facilitating the recovery from stress to the resting levels via attenuation of both GC release and SNS activity as well as by increased NO-dependent vasorelaxation. On the other hand, reduced levels of NO were observed in the later phases of stress and in subjects with genetic predisposition to hypertension, irrespectively, in which reduced NO bioavailability may account for disruption of NO-mediated BP regulatory mechanisms and accentuated SNS and GC effects. This review summarizes current knowledge on the role of stress in development of hypertension with a special focus on the interactions among NO and other biological systems affecting blood pressure and vascular function.
VLOG : A TOOL FOR STUDENTS’ SPEAKING PRACTICE ENHANCEMENT
Authors: Anggraeni Anita , Rachmijati Cynantia , Apriliyanti Dewi Listia
Published: February 2020

Vlog, stands for video-blogging, is quite popular in the internet. Vlog also can be used as a learning tool especially for speaking skills. Therefore this research focuses on speaking skill via vlog to see the improvement of students’ speaking skill. The method of this research was mixed methods. The research subjects were 13 vlogs made by students on the topic of spot tourism. The 13 vlogs were by assessed using the rubric developed by Dan Rooney (1998). The result found out that using vlog deemed to be improving students’ speaking skill especially in the area of vocabulary, fluency, pronunciation and intonation. However the most common mistakes found are the way they delivered the introduction, how to form conclusions and the last is the grammatical structure. The findings of the research conclude that the application of vlog to improve students’ speaking skill found to be successful with a positive perception from students as learning tool.
LISTENING COMPREHENSION STRATEGIES EMPLOYED BY INDONESIAN EFL STUDENTS: LESSON LEARNED FROM INDONESIAN ISLAMIC HIGHER EDUCATION
Authors: Fetriani Fetriani , Baluqiah Kiagus , Fransiska Meta
Published: February 2020

The objective of this research is to know the strategies in acquiring listening comprehension used by English students in English classes of Islamic university in Bengkulu, Indonesia.  The data of the research included questionnaire and interview the result of this research, there were two strategies in acquiring listening: First in direct strategies they were memory, cognitive and compensation strategies. Second in indirect strategies they are metacognitive, affective and social strategies. Especially in direct strategies, memory was the most strategy was chosen by students in the second semester. Indirect strategies, social was the most strategy was chosen by student. So the most strategies used by English students are memory and social strategy. The objective of this research is to know the strategies in acquiring listening comprehension used by English students in English classes of Islamic university in Bengkulu, Indonesia.  The data of the research included questionnaire and interview the result of this research, there were two strategies in acquiring listening: First in direct strategies they were memory, cognitive and compensation strategies. Second in indirect strategies they are metacognitive, affective and social strategies. Especially in direct strategies, memory was the most strategy was chosen by students in the second semester. Indirect strategies, social was the most strategy was chosen by student. So the most strategies used by English students are memory and social strategy
The Analysis of Influencing Factors of Performance of Community Time Bank Mutual Assistance Services Based on SEM Model Empirical Data from Nansha District, Guangzhou, China
Authors: Pan Daoqin , Wu Yijing
Published: February 2020

Based on the 3E Methodology, in this study, the performance of community time bank mutual assistance services are empirically evaluated from three aspects of economy, effectiveness, and efficiency. We investigate and then hypothesize four impacts that affect the performance of community time bank mutual assistance services, including external supervision, organizational credibility, organizational management, and public welfare atmosphere. Therefore, the empirical data from Nansha District, Guangzhou, China, and the Structural Equation Model are used to empirically test the above hypotheses. The results show that: first, the performance of community time bank mutual assistance services is at a medium level; second, external supervision has a positive effect on the efficiency and effectiveness of time bank mutual assistance services, but no significant relationship with economy; third, organizational credibility has a positive effect on the efficiency and effectiveness, but no significant relationship with economy; forth, organizational management has a positive effect on the economy, efficiency and effectiveness; fifth, public welfare atmosphere has a positive effect on the efficiency, but no significant relationship with economy and effectiveness. Based on the above results, four policy recommendations to promote the sustainable development of community time bank mutual assistance services are also provided.
DO EMERGING MARKET FIRMS SACRIFICE ECONOMIC VALUE FOR GROWTH?
Authors: Deligonul, Ph.D. Seyda , Sacks, Ph.D. Jana
Published: February 2020

In this article, we focus on emerging market firms, often operating with no or negative EVA rendering them financially fragile. We argue that economic distress does not necessarily drive going concern distress, nor does it drive economically unsound performance. We provide a framework for added value performance assessment and analyze emerging market firms in their growth patterns. We develop a pertinent theory to explain the observation of value loss and its relationship to some underlying factors. While emerging market firms may behave in a way in which they indeed destroy economic value, they also usually sustain their ability to deliver a going-concern premium.
Forecasting Bubble Bursts Assessing the Ex-ante Usability of the Log-Periodic Power Law Singularity Model
Authors: Gustavsson Marcus , Levén Daniel , Sjögren Professor Hans
Published: February 2020

Speculative bubbles have throughout the times foiled various scholars; many have tried to accurately predict their ends, but few have succeeded. In this study, we examine the robustness and ex-ante usability of the log-periodic power-law model in predicting end dates of speculative bubbles on one mature and two emerging financial markets. We have found that the predicted end dates are somewhat dependent on at which point in time the prediction is conducted, especially in regards to at which point in the oscillatory cycle the prediction is conducted. This is mostly due to that predictions are sensitive to their most recent price movements, especially when data is limited and a clear oscillatory pattern is not yet established. We conclude that observing one particular estimation without further context can be misleading. To achieve a sound understanding of and reasonable expectations on how prices might develop it is necessary to follow a bubble as it develops. This study is, to our knowledge, first to examine to what extent the predictions of the model are dependent on at which point in time the predictions are conducted.
THE INFLUENCE OF ORGANIZATIONAL CULTURE AND DISCIPLINE ON ORGANIZATIONAL PERFORMANCE THROUGH ORGANIZATIONAL CITIZENSHIP BEHAVIOR IN THE INSPECTORATE OF BEKASI CITY INDONESIA
Authors: Rianawati Nita Desi , Suharto Suharto , Widodo Djoko Setyo
Published: February 2020

This study aims to determine the effect of organizational culture and discipline on organizational performance simultaneously, determine the influence of organizational culture on organizational performance partially, determine the effect of discipline on organizational performance partially, determine the effect of organizational citizenship behavior on organizational performance partially, know the influence of culture organization on performance through organizational citizenship behavior and know the effect of discipline on organizational performance through organizational citizenship behavior variables. The study was carried out at the Bekasi City Inspectorate Organization. Sampling uses a saturated sample involving 86 employees in all parts of the organization. Data analysis uses path analysis.
Based on data analysis, it is known that organizational culture variables partially influence organizational performance. T value of 5.055. The significance value is 0.00. This significant value is smaller than 0.05. The value of r squared is 0.233. This means that the influence of organizational culture variables on performance by 23.3% and the rest is influenced by other variables not included in the equation model.
Discipline variables partially affect organizational performance. T value of 7.282. The significance value is 0.00. This significant value is smaller than 0.05. The value of r squared is 0.387. This means that the influence of disciplinary variables on organizational performance is 38.7% and the rest is influenced by other variables not included in the equation model.
The variable of organizational citizenship behavior partially influences organizational performance. T value of 14.834. The significance value is 0.00. This significant value is smaller than 0.05. The value of r squared is 0.724. This means that the influence of organizational culture variables on organizational performance by 72.4% and the rest is influenced by other variables not included in the equation model.
The influence of organizational culture on organizational performance is 0.483. The influence of organizational culture on performance through organizational culture is 0.614x0.851 =0.5191. In this case, the indirect effect is greater than the direct effect so it can be said that the variable of organizational citizenship behavior as an intervening variable.
The direct effect of discipline on organizational performance is 0.622. While the influence of discipline on organizational performance through organizational citizenship behavior is 0.762x0.851 = 0.648. In this case, the direct effect is smaller than the indirect effect so it can be said that the variable of organizational citizenship behavior as an intervening variable.
Will They Turn the Other Cheek? Decision Making and Victim’s Religious Self-Identification
Authors: Depken, II. Craig A. , Wilson Dennis P.
Published: February 2020

This paper examines the implications for potential victims of crime through religious self- identification. If a criminal can choose between an unidentified victim and a religiously self-identified individual, all else equal whom does he choose to victimize? We use religious self-identification to indicate that a person is a believer of Pascal’s Wager while the criminal does not subscribe to the wager. We then derive game-theoretic decision matrices to depict the potential payoffs to a victim from resisting or conceding to the criminal activity. A similar analysis is conducted from the criminal’s perspective to determine who to victimize. This analysis helps sheds light upon the decision of religiously motivated suicidal action and the decision of whom to victimize.