bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the influence of built environment on demand of online car-hailing travel using multi-scale geographically temporal weighted regression model
Authors: Cheng Rongjun , Zeng Wenbao , Zheng Yuchen
Published: June 2023

The demand for online car-hailing travel is influenced by the built environment, which exhibits spatio-temporal heterogeneity in its impact. Previous studies have commonly employed geographically weighted regression (GWR) model and geographically temporal weighted regression (GTWR) model to examine the relationship between demand for online car-hailing trips and built environment. However, these studies have overlooked the scales of influence different built environment variables. This study addressed this issue by considering scale effects based on GTWR to form the multi-scale geographically temporal weighted regression (MGTWR) to explore the spatio-temporal impact of the urban built environment on the demand for online car-hailing trips. An empirical study was conducted to assess the effectiveness of MGTWR model using Point of Interest (POI) data and online car-hailing orders data in Haikou. The evaluation indicators showed that the MGTWR model has higher accuracy in fitting than the GTWR model. Moreover, the impact of each type of POI on demand of online car-hailing travel was analyzed by examining the temporal and spatial distribution of the regression coefficients.
Comprehensive quantitative analysis of erythrocytes and leukocytes using trace volume of human blood using microfluidic-image cytometry and machine learning
Authors: Moradi Nima , Hoseyni Fateme Haji Mohamad , Hajghassem Hassan , Yarahmadi Navid , Shirvan Hadi Niknam , Safaie Erfan , Kalantar Mahsa , Sefidbakht Salma , Amini Ali , Eeltink Sebastiaan
Published: June 2023

A diagnostic test, based on microfluidic image cytometry and machine learning has been designed and applied for accurate classification of erythrocytes, leukocytes including 5-part differentiation into neutrophils, lymphocytes, monocytes, eosinophils, and basophils using minute amounts of whole blood using in a single counting chamber. A disposable multilayer microdevice for microfluidic image cytometry was developed that comprises a 1 mm x 22 mm x 50 µm (w x l x h) rectangular microchannel, allowing the analysis of trace volume of blood 20 µL for each assay. Automated analysis of digitized binary images applying a border following algorithm was performed allowing to qualitative analysis of erythrocytes. Bright-field imaging was for the detection of erythrocytes and fluorescence imaging for 5-part differentiation of leukocytes after acridine orange staining applying a convolutional neural network enabling fast segmentation and automated feature extraction yielding 98.57% accuracy. Blood samples were obtained from 30 volunteers and count values did not significantly differ from data obtained using a commercial automated hematology analyzer.
Use of Pushover Analysis to Compare the Seismic Response of Columns with Unusual Shapes of Shear Wall
Authors: HANDE SUSHANT , YADAV ADINATH
Published: June 2023

In terms of seismic qualities, a regular RC frame with conventional columns was compared to a regular RC frame with discrete shaped shear walls merely on the frame's perimeter and circular columns employed in the inner half of the RC frame. Static nonlinear analysis, sometimes referred to as push over analysis was used to apply the lateral loads in opposition to the gravity loads. Additionally, the RC structure's overall height was taken into consideration. Push over analysis is used to forecast the post-elastic behaviour of the overall structure under study. The stages of hinge formation assist in determining the structure's performance level. The modelling, analysis, and result interpretation were done using the ETAB software, which is based on the Finite Element Method. Response Spectrum Method was used for push over analysis. The Lateral load application analysis was done using a Displacement controlled approach. At the structure's performance point, all seismic characteristics were compared. The performance point is defined as the point at where the demand and capacity curves intersect. There were three different sets of models made in all, each with a unique horizontal plan geometry. The first set is laid out in a rectangular pattern, the second is in a L-shape, and the third is in a T-shape.
The total height of the construction was covered by plan sets. It includes G+6 models for RC frames with square columns and RC frames with asymmetric columns around the frame. According to the findings, RC frames with rectangular columns perform better at withstanding lateral strain than frames with discretely formed shear walls and circular columns for all three sets of models with G+6.
Costs of Summer Youth Employment to Prevent Violence: An Analysis and Implementer’s Tool
Authors: Schnippel Kathryn , Larson Bruce , Jay Jonathan , Szkola Jason , O'Toole Megan J.
Published: June 2023

Gun homicide rates have risen 35% across the US since the start of the COVID-19 pandemic. One promising intervention to prevent violent crime is summer youth employment programs (SYEPs), which provide youth with meaningful workplace experiences, prosocial engagements, and developmental opportunities during the summer months, when many otherwise lack structure. This paper presents a cost analysis of violence prevention-focused SYEPs to help implementers understand the costs generally and in their own community contexts—to advocate for adoption and secure funding of, effectively budget for, and successfully implement SYEPs. Researchers use an ingredients-based costing approach and provide a template for implementers to use and adapt for their context. SYEPs with the goal of reaching youth who are justice-involved or at risk of being victims or perpetrators of violence can cost $3,331 per youth assisted, with 54% of this cost directly paid to youth through stipends. Cost per youth is driven by the intensity of the mentoring and support that community organizations provide to the program participants. Knowing the cost per youth assisted can inform further analysis, implementation, and expansion of SYEPs.
LINC02582 Sponges MiR-375 To Promote The Lung Metastasis Of Colorectal Cancer Via Lactate Dehydrogenase B Dependent Glycolysis
Authors: Song Wang , Zhu Congcong , Zhu Zhonglin , Li Cong , Cai Sanjun , Quan Bin , Liu Fangqi , Xu Ye
Published: June 2023

Glycolysis plays significant roles in reprogramming the metastatic tumor microenvironment. Many lncRNAs have been reported to function as oncogenes by regulating glycolysis. In the present study, we found that the expression of LINC02582 gradually increased from adjacent normal to colorectal cancer (CRC), especially in Stage IV tumor tissues, and high LINC02582 expression predicted poor survival, especially for patients with lung metastasis. Functionally, LINC02582 promoted the glycolysis and invasion of CRC cells in vitro and enhanced their lung metastasis in vivo. Mechanically, LINC02582 functioned as a ceRNA to regulate lactate dehydrogenase B (LDHB) expression via sponging miR-375, resulting in glycolysis of CRC cells and leading to their invasion and lung metastasis. Clinically, high LINC02582 and LDHB expression predicted poor survival of CRC patients. In conclusion, the present study identified LINC02582 as an onco-lncRNA in CRC and demonstrated that the combination of LINC02582 /miR375/LDHB may be a potential prognostic biomarker of CRC with lung metastasis.
Changes in patient admission patterns at orthopedics and traumatology outpatient clinics before and after the earthquakes on 6 February 2023 in Turkey
Authors: Asfuroğlu Zeynel Mert , Gümüşoğlu Ender
Published: June 2023

Background
The increase in orthopedic injuries after earthquakes imposes a significant burden on the health system. However, the impact of earthquakes on outpatient admissions remains unclear. This study compared patient admissions to the orthopedics and traumatology outpatient clinics before and after earthquakes.
Methods
The study was conducted at a tertiary university hospital near the earthquake zone. In total, 8,549 outpatient admissions were retrospectively analyzed. The study population was divided into pre-earthquake (pre-EQ) and post-earthquake (post-EQ) groups. Factors such as gender, age, city of origin, and diagnosis were compared between the groups. In addition, unnecessary outpatient utilization (UOU) was defined and analyzed.
Results
The pre-EQ and post-EQ groups included 4,318 and 4,231 patients, respectively. The two groups had no significant differences in age and sex distribution. However, the proportion of non-local patients increased after the earthquake. UOU was the most common reason for admission in both groups. The distribution of diagnoses differed significantly between the pre-EQ and post-EQ groups, with an increase in the number of trauma-related diagnoses and a decrease in UOU after the earthquake.
Conclusions
Our findings suggest that the effects of earthquakes on daily orthopedic practice are long-lasting. The pattern of outpatient admissions changes, with an increase in frequency of trauma-related diagnoses.
Level of evidence: Observational study
PSMB2: A potential immunological and prognostic Signature in glioma
Authors: He Wei , Zhang Zhe , Tan ZiLong , Liu XinXian , Wang ZeKun , Xiong Bo , Shen XiaoLi , Zhu XinGen
Published: June 2023

There has been an upward trend in the incidence of glioma, with high recurrence and high mortality. The beta subunits of the 20S proteasome are encoded by the proteasome beta (PSMB) genes and may affect the proteasome's function in glioma, assembly and inhibitor binding. This study attempted to reveal the function of the proliferation and invasion of glioma cells, which is affected by proteasome 20S subunit beta 2 (PSMB2). We subjected the data downloaded from the TCGA database to ROC, survival, and enrichment analyses. PSMB2 expression was verified by quantitative PCR and Western blotting to identify the mRNA and protein levels. PSMB2 expression was higher in glioma tissues, and its expression positively correlated with poor prognosis and high tumor grade.
Treatment of central nervous system relapse in PLZF::RARA-positive acute promyelocytic leukemia by venetoclax combined with arubicin and cytarabine: a case report
Authors: Zhou Zhonghao , Zhu Feng , Wang Hui , Lu Fengyan , Xue Hongyi
Published: June 2023

Background: Patients with refractory acute promyelocytic leukemia and central nervous system relapse often have a poor prognosis. Among them, patients with the PLZF::RARA rearrangement have a poor response to all-trans retinoic acid and conventional chemotherapy. Venetoclax, a selective inhibitor of B-cell lymphoma-2 (BCL-2), can cross the blood–brain barrier and has been widely used in the treatment of acute myeloid leukemia in recent years.
Case presentation: We report a case of central nervous system relapse in a patient with acute promyelocytic leukemia with PLZF::RARA rearrangement who achieved complete remission after treatment with anthracycline cytotoxic chemotherapy in combination with venetoclax. The concentration of venetoclax in the cerebrospinal fluid (CSF) was found to be approximately 1/1000 of that in the plasma based on liquid chromatography–tandem mass spectrometry. After the first treatment course, the PLZF::RARA test result for the patient’s marrow fluid sample turned negative. After the third treatment course, abnormal promyelocytic leukemia cells in the CSF were not detected using flow cytometry, and the PLZF::RARA test in the CSF remained negative.
Conclusion: This case report highlights a new approach to the treatment of central nervous system relapse in patients with PLZF::RARA-positive acute promyelocytic leukemia.
Bayesian belief network modeling approach for predicting and ranking risk factors for malaria infections among children under five years in refugee settlements in Uganda
Authors: Semakula Henry Musoke , Liang Song , Mukwaya Paul Isolo , Mugagga Frank , Nseka Denis , Wasswa Hannington , Mwendwa Patrick , Kayima Patrick , Achuu Simon Peter , Nakato Jovia
Published: June 2023

Background
Malaria risk factors at household level are known to be complex, uncertain, stochastic, nonlinear, and multidimensional. The interplay among these factors, makes targeted interventions, and resource allocation for malaria control challenging. However, few studies have demonstrated malaria’s transmission complexity, control, and integrated modeling, with no available evidence on Uganda’s refugee settlements. Using the 2018–2019 Uganda’s Malaria Indicator Survey (UMIS) data, an alternative Bayesian belief network (BBN) modelling approach was used to analyse, predict, rank and illustrate the conceptual reasoning, and complex causal relationships among the risk factors for malaria infections among children under-five in refugee settlements of Uganda.
Methods
In the UMIS, household level information was obtained using standardized questionnaires, and a total of 675 children under 5 years were tested for malaria. From the dataset, we created a casefile containing malaria test results, demographic, social-economic and environmental information. The casefile was divided into a training (80%, n = 540) and testing (20%, n = 135) datasets. The training dataset was used to develop the BBN model following well established guidelines. The testing dataset was used to evaluate model performance.
Results
Model accuracy was 91.11% with an area under the receiver-operating characteristic curve of 0.95. The model's spherical payoff was 0.91, with the logarithmic, and quadratic losses of 0.36, and 0.16 respectively, indicating a strong predictive, and classification ability of the model. The probability of refugee children testing positive, and negative for malaria was 48.1% and 51.9% respectively. The top ranked malaria risk factors based on the sensitivity analysis included: (1) age of child; (2)roof materials (i.e., thatch roofs); (3)wall materials (i.e., poles with mud and thatch walls); (4)whether children sleep under insecticide-treated nets; 5)type of toilet facility used (i.e., no toilet facility, &pit latrines with slabs); (6)walk time distance to water sources, (between 0–10minutes); (7)drinking water sources (i.e., open water sources, and piped water on premises).
Conclusion
Ranking, rather than the statistical significance of the malaria risk factors, is crucial as an approach to applied research, as it helps stakeholders determine how to allocate resources for targeted malaria interventions within the constraints of limited funding in the refugee settlements.
Establishment of a differential diagnosis method and an online prediction platform for AOSD and sepsis based on machine learning
Authors: Zhou Dongmei , Xie Jingzhi , Wang Jiarui , Zong Juan , Fang Quanquan , Luo Fei , Zhang Ting , Ma Hua , Cao Lina , Yin Hanqiu , Yin Songlou , Li Shuyan
Published: June 2023

Objective. The differential diagnosis between Adult-onset Still's disease (AOSD) and sepsis has always been a challenge. In this study, a machine learning model for differential diagnosis of AOSD and sepsis was developed and an online platform was developed to facilitate the clinical application of the model.
Methods. All data were collected from 42 AOSD patients and 50 sepsis patients admitted to Affiliated Hospital of Xuzhou Medical University from December 2018 to December 2021. In addition, 5 AOSD patients and 10 sepsis patients diagnosed in our hospital after March 2022 were collected for external validation. All models were built using the scikit-learn library (version 1·0·2) in Python(version 3·9·7), and feature selection was performed using the SHAP (Shapley Additive exPlanation) package developed in Python.
Results. The results showed that the gradient boosting decision tree(GBDT) optimization model based on arthralgia, ferritin × lymphocyte count, white blood cell count, ferritin × platelet count, and α1-acid glycoprotein/creatine kinase could well identify AOSD and sepsis. The training set interaction test (AUC: 0·9916, ACC: 0·9457, Sens: 0·9556, Spec: 0·9578) and the external validation also achieved satisfactory results (AUC: 0·9800, ACC: 0·9333, Sens: 0·8000, Spec: 1·000). We named this discrimination method AIADSS (AI-assisted discrimination of Still's disease and Sepsis) and created an online service platform for practical operation, the website is http://cppdd.cn/STILL1/.
Conclusion. We created a method for the identification of AOSD and sepsis based on machine learning. This method can provide a reference for clinicians to formulate the next diagnosis and treatment plan.
Urological training during the COVID-19 pandemic: Our Initial Experience of TURP simulator in Singapore Residency Training and its increasing relevance for surgical skills training
Authors: Lim Ee Jean , Gan Valerie Huei Li , Ong Julene Hui Wun , Foo Malia Alexandra , Fong Khi Yung , Sim Allen , Ho Henry Sun Sien , Lau Weber Kam On , Ong Caroline Choo Phaik , Aslim Edwin Jonathan , Gauhar Vineet , Yuen John Shyi Peng , Chen Kenneth
Published: June 2023

Purpose: Urological training in Singapore has seen a reduction in length of training and shortened working hours to fit requirements of the residency model. Virtual reality(VR) simulators may contribute as an adjunct to shorten the learning curve and acquire surgical skills. This study assesses the construct validity of a transurethral resection of prostate(TURP) simulator and its pilot study in urological residents.
Methods: The study first assessed the construct validity of the VirtaMed UroS™️ simulator with 12 novices and 12 experts. A pilot study involving 12 junior(JR) and 15 senior urology residents(SR) was then conducted. Participants were given 2 attempts to complete the same task. Performance indicators include: Percentage of prostate resected(PR), Completion time, the time that loop diathermy was active without tissue contact(TAWC), percentage of capsule resection(CR).
Results: Construct validity was demonstrated: experts had significantly greater PR (40.6% vs 11.9%, p<0.05) and less TAWC than novices (0.13s vs 13.9s, p<0.05). JR demonstrated an increase in PR (13.3% vs 26.7%, p=0.0005) and a decrease in TAWC when comparing attempts (4.5s vs 1.3s, p= 0.003). Although statistically insignificant, increased PR (30.2 vs 40.5, p=0.1) and decreased TAWC (1.1 vs 0.9, p=0.84) was demonstrated when comparing attempts by SR. In the 2nd attempt, both groups demonstrated a decrease in TAWC with JR showing a greater decrease (2.9 vs 0.4, p<0.05).
Conclusion: This pilot experience shows that the TURP simulator may provide time-efficient learning to supplement urological training. Further research and incorporation of VR simulation is needed to develop more robust and comprehensive training programmes.
An auto-scaling approach for microservices in cloud computing environments
Authors: ZargarAzad Matineh , Ashtiani Mehrdad
Published: June 2023

Today, web applications are one of the most common applications providing service to users. Web application providers have moved their applications to cloud data centers. In this regard, microservices have become a famous architecture for building cloud-native applications. Cloud computing provides flexibility for service providers, allowing them to remove or add resources depending on the workload of their web applications. If the resources allocated to the service are not aligned with its requirements, failure or delayed response will increase, resulting in customer dissatisfaction. This problem has become a significant challenge in microservices-based applications because thousands of microservices in the system may have complex interactions. Auto-scaling is a feature of cloud computing that enables resource scalability on demand. This allows service providers to deliver resources to their applications without human intervention under a dynamic workload to minimize resource cost and latency while maintaining the Quality of Service (QoS) requirements. In this research, we aimed to establish a computational model for analyzing the workload of all microservices. This is performed by considering the overall workload entered into the system and taking into account the relationships and call functions between microservices. This is because, in a large-scale application with thousands of microservices, it is usually difficult to accurately monitor all the microservices and gather precise performance metrics. Then, we introduce a multi-criteria decision-making method to select candidate microservices for scaling. The results of the conducted experiments show that the detection of input load toward microservices is performed with an average accuracy of 99% which is a significant value. Also, the proposed approach improves the maximum use of resources by an average of 22.73%, reducing the number of scaling times by 69.82%, and finally reducing the number of required resources which also affects the cost by 1.67% compared to existing approaches.
Investigation of morphology and catalytic behaviour of vanadyl ions embedded in ammonium heptamolybdate as efficient nanocomposite catalyst for epoxidation of allyl alcohols
Authors: Farzaneh Faezeh , Yeroushalmi Rebecca , Azarkamanzad Zahra
Published: June 2023

In this study nano composites using vanadyl sulfate and ammonium heptamolybdate were synthesized under reflux conditions. The obtained results indicated that the ratio of starting materials as well as reaction condition (reflux) have an important role in the morphology of the prepared composites. The prepared composites were characterised using FT-IR, SEM, EDX, XRD, ICP and TGA techniques. Then, it was found that the prepared composites successfully catalyze the epoxidation of allyl alcohols with tert-buthylhydroperoxide (TBHP) in high yields. The epoxidation of geraniol, trans − 2-hexene-1-ol, 1-octene- 3-ol and 3-methyl-2-butene-1-ol with 100% selectivity is promising. stability, reusability and high efficiency of composites are the advantages of these composites.
Designing Subgrade for Flexible Pavement in Bottom Ash, Lime and Sodium Hexametaphosphate Stabilized Expansive Soil
Authors: Rana Shiwani , Singh Sandeep , Sharma Abhishek
Published: June 2023

The current study examines the effective use of wastes, bottom ash which is mixed with lime and sodium hexametaphosphate (NAPO3)6, to stabilize the expansive soil in order to make a composite subgrade material for flexible pavement design. The study involves performing laboratory tests on expansive soil samples containing bottom ash and lime alone and along with (NAPO3)6, such as differential free swell, consistency limits, compaction characteristics, unconfined compressive strength tests and California bearing ratio. The results showed that adding an optimal amount of bottom ash (15%), lime (6%), and (NAPO3)6 (4.5%), both alone and in combination, reduces the differential free swell and consistency limits of expansive soil and increased the CBR values, accomplishing it into an effective subgrade material. The thickness of flexible pavement was designed using IITPAVE software by utilising the obtained CBR values, it met the required parameters based on the IRC: 37-2018 recommendations. The software analysis revealed a reduction in pavement thickness for different commercial vehicle traffic volumes (1000, 2000, and 5000), with the highest reduction in layer thickness and construction costs observed when expansive soil was combined with bottom ash (15%), lime (6%), and (NAPO3)6 (4.5%). This technology not only improves the geotechnical characteristics of subgrade soil, but it is also cost-effective and tackles the bottom ash disposal issue. Overall, this research proposes a novel method for developing a composite soil subgrade material for flexible pavement.
Future sexual dysfunctions of hypospadias patients who was operated in childhood
Authors: Kılıç Sinan , Verep Samed
Published: June 2023

Background: Hypospadias is a congenital anomaly that can be seen in every 300 male births and may cause sexual dysfunction in the future. Aim: This study focused on the possible future sexual dysfunction of children who were diagnosed with hypospadias and experienced treatment processes.
Methods: Thirty male patients who were diagnosed with Hypospadias and completed the treatment process between November 2022 and March 2023 were included in the prospective study. Patients' age, BMI, and age of the patient at the surgery were recorded. Sexual functions were assessed with the Arizona Sexual Experiences Scale (ASEX). Outcomes: Sexual dysfunctions were found to be significantly higher in individuals who had undergone hypospadias surgery.
Results: Patients with hypospadias diagnosed and operated in childhood, the mean age was 27.2±4.6, BMI was 24.8±1.6, and the time to diagnosis of hypospadias was 3.8±0.9. Although 55% of the patients in the study were single, 45% were married.
Clinical Implications: In the first clinical examination after hypospadias surgery, it is checked whether there is an aesthetically correct penis and meatus, and whether the child is voiding properly. A child who has an aesthetically good penis and can urinate in the right size and in the right direction is considered successful. Sexual dysfunctions are longer-term consequences. We observed that these sprains were more than expected after hypospadias surgery. Long-term follow-up of patients who have undergone hypospadias surgery, especially proximal repair, should be done closely.
Strengths & Limitations: Streng The limitation of the study is the small number of patients who applied to the clinic as a result of all patients who developed sexual dysfunction after hypospadias surgery. The second limitation is the tendency to hide sexual problems experienced.ths & Limitations.
Conclusion: As a result of the study, it was concluded that the sexual dysfunction of the patients was more severe than expected.
A new bird calicivirus detected in feces of cormorant
Authors: Wang Yan , Zhao Ran , Sun Yijie , Wu Yan , Ji Likai , He Yuyun , Hou Jingjing , Qin Zhaoying , Yang Shixing , Zhang Wen
Published: June 2023

The incidence of reporting caliciviruses in wild birds is less common than in other animals, and the majority of cases remain unclassified. A strain of calicivirus was discovered in this study in the feces of cormorants collected at Xiamen Horticulture Expo Garden in 2021 and was named Cormcali01. The genome of Cormcali01 was 8,561 bp in length which contained characteristic motifs present in other caliciviruses. Furthermore, it showed significant divergence from all available calicivirus nucleotide sequences, with the highest similarity to the unclassified Ruddy turnstone calicivirus A (47.34%). Pairwise comparison of the VP1 protein showed that Cormcali01 had the highest amino acid identity of 43.90% with the unassigned Ruddy turnstone calicivirus A. Phylogenetic analysis demonstrated that VP1 of Cormcali01 clustered with unassigned caliciviruses. Therefore, based on phylogenetic analysis and pairwise comparison, Cormcali01 should be affiliated with the unassigned calicivirus, which were suggested to comprise a new calicivirus genus, the Sanovirus genus. After investigating the prevalence of Cormcali01, we discovered that 22.22% of fecal samples (10/45) were tested positive. These findings expanded our understanding of the genetic variation of caliciviruses and provided valuable epidemiological information regarding a potential outbreak of calicivirus disease in birds.
DDX5 enhances proliferation and metastasis of Head and Neck Squamous Cell Carcinoma via β-Catenin signaling pathway activations
Authors: Chen Qi , Ji Yingying , Zheng Xiaoying , Sheng Jiying , Ren Qiang , Wei Kuijie
Published: June 2023

Head and neck squamous cell carcinoma (HNSCC) is extremely challenged to undergo sNurgeries and the underlying mechanisms behind it remain unclear. We evaluated whether DDX5 functions indispensably in HNSCC prognosis and found that DDX5 is up-regulated among HNSCC samples and overexpression enhances HNSCC. The β-catenin signaling pathway activation with the DDX5 assistance promotes HNSCC in vitro. Targeting β-catenin signaling pathway utilizing MSAB as inhibitor successfully ameliorates HNSCC in subcutaneous injection mouse model in vivo as well as malignant functions in vitro. Our findings elucidate that DDX5 might function as an oncogenic biomarker for HNSCC, which could be a candidate target in clinical therapies.
Circling the Void: Using Heidegger and Lacan to think about Large Language Models
Authors: Heimann Marc , Hübener Anne-Friederike
Published: June 2023

This essay bridges two disparate lines of inquiry: Large Language Models (LLMs) and continental philosophy, specifically Martin Heidegger's reflections on language and Jacques Lacan's structural psychoanalysis grounded in Sigmund Freud's theories. We argue that the linguistic conceptualizations put forth by Heidegger, Freud, and Lacan, primarily employed in clinical frameworks, find surprising resonance in the operations of modern LLMs. This parallel allows us to bring into focus a central theme of continental discourse—negation and negativity—largely absent in current LLM research. Our approach diverges radically from conventional philosophy of artificial intelligence, which primarily engages with analytic philosophy. Here, we build our discourse on thinkers often overlooked in this field, delineating the ontological differences of our approach. Our goal is to foster a dialogue between AI researchers and continental philosophers, highlighting the mutual insights that these two distinct perspectives can offer.
Harnessing Fe 2 O 3 to Improve HAP Composites: Investigating Radiation Shielding, Mechanical Attributes, and Magnetic Field Effects
Authors: Malidarre Roya Boodaghi , Akkurt Iskender , Zakaly Hesham M.H. , Korkmaz Abdul Vahap , Ekmekci Ismail
Published: June 2023

Hydroxyapatite (HAP) bio-composites are widely utilized for the repair and replacement of bone and teeth tissues in humans. However, due to their suboptimal mechanical properties, the strength and durability of pure HAP have been improved by incorporating various alloys and materials. This study examines the radiation shielding and mechanical properties of Fe2O3-reinforced HAP composites for use as implants, with Fe2O3 concentrations of 0.0, 2.5, 5.0, and 7.5 wt.%. The study also investigates the composite's behavior in a magnetic field. Using the FLUKA Monte Carlo Code, radiation shielding factors are determined, and the mechanical properties of the composites are assessed through theoretical methods. Results indicate that increasing Fe2O3 content in HAP bio-composites enhances the radiation shielding and mechanical properties of the selected samples. Additionally, without a magnetic field, particle distribution displays symmetry along the x-axis; however, when exposed to a magnetic field of Bx=5 microT, a distinct pattern emerges.
Evaluation of vaccine efficacy and snail control on the transmissionof Schistosoma Haematobium in Communities around the Volta Lake in Ghana
Authors: Agana Francis , Obeng-Forson Ferdinard , Ohene-Ayeh William , Armah-Agyeman Emmanuel
Published: June 2023

Following some successes recorded in recent clinical trials of vaccine in mice and rodentsof a Schistosomiases also known as the snail fever, we present in this work a mathematicalmodel to assess the potential impact of vaccine discovery on the spread of the disease incommunities around the Volta lake in Ghana, West Africa. We present also the efficacy ofa hybrid method that involves the combination of vaccine administration and an age oldpractice of controlling the population in schistosomiasis prone areas as a control strategyagainst the disease.
Economic Impact of Soil Losses in Pineapple Crops (Ananas Comosus L. Merr) In the Valle Del Cauca, Colombia
Authors: López Carolina Martínez , Flores Juan Carlos Menjívar , Muñoz Luis Fernando Delgado
Published: June 2023

Soil erosion generates nutrient and crop yield losses and environmental and economic impacts. The research evaluated the economic impact of soil and nutrient losses in pineapple cultivation in the department of Valle del Cauca, Colombia. A total of nine runoff plots were established in the main producing municipalities, where the evaluation was carried out during two complete rainy periods (2019–2020). Subsequently, the loss of soil as well as nutrients (N, P, K, Ca, Mg, B, Mn, Cu, Zn, Fe ) was calculated, and its economic value was determined by the replacement cost method. Losses of clay and organic matter were included in the analysis. Soil losses varied from 40 to 261 t/ha/year, which corresponds to moderate to very high degrees of erosion, with Dagua being the most affected municipality. It was found that among the farms that showed the greatest losses of nutrients, the most affected were potassium, iron, and manganese with values of up to 535 kg/ha, 330 kg/ha, and 177 kg/ha, respectively; however, at a general level, the main losses occurred for potassium and nitrogen. Finally, the economic losses ranged from US$ 1266.15 to more than US$ 5908.70 per plot, representing losses of up to US$ 14367177.80 for the total area planted with pineapple, which implies serious economic repercussions for farmers in the region.
Avaliação do Nível de Conhecimento de Acadêmicos e Profissionais de Odontologia sobre as Manifestações Orais Associadas ao COVID-19
Authors: Oliveira Dara Karen Freire de , Lima Luis Henrique Guedes de Andrade , Souza Jefferson Jorge Morais de , Pessôa Katarina Haluli Janô da Veiga , Dantas Fernanda Suely Barros , Cavalcanti Mariana Silva Teixeira , Bezerra Danilo do Nascimento , Leão Jair Carneiro , Carvalho Alessandra de Albuquerque Tavares
Published: June 2023

A COVID-19 causa, além dos sintomas respiratórios, manifestações orais pertinentes que agravam o quadro clínico do paciente. Objetivo: Averiguar o nível de conhecimento dos acadêmicos e profissionais de odontologia acerca das manifestações orais associadas a COVID-19. Materiais e métodos: Utilizou-se um questionário (autoaplicável) na plataforma Google Forms para acadêmicos de odontologia a partir do 6° período e cirurgiões-dentistas. O questionário englobou 10 questões de múltipla-escolha. Posteriormente, os dados de cada questão foram classificados em percentuais de acertos, erros e "não sabia". Resultados: A maioria dos participantes era do sexo feminino (72%). Mais da metade (55%) respondeu possuir conhecimento sobre a ligação entre o vírus e o receptor. 56% sabiam como se desencadeavam as manifestações orais. 90% conheciam ao menos uma forma delas. E 59% conheciam a relação entre antibióticos de amplo espectro e o surgimento da Candidose oral. Além disso, 55% dos participantes sabiam que os fármacos utilizados nos pacientes com Covid-19 causam alterações orais. 60% dos participantes tinham clareza sobre as origens das coinfecções. 84% dos participantes sabiam da relação entre as interfaces psíquicas e emocionais. Conclusão: A maior parte dos acadêmicos de odontologia e cirurgiões-dentistas possui nível de conhecimento moderado acerca das manifestações orais relacionadas ao Covid-19. Contudo, ainda faz-se necessário contínuas atualizações e capacitações sobre a COVID-19.
Determining our Destination: The Future of Professional Counterspaces for African American Women in Student Affairs
Authors: West Nicole M. , Smith Michele D.
Published: June 2023

This basic qualitative study catalogued the collective insight of Black women student affairs professionals regarding the development and evolution of professional counterspaces in the future. Focus group discussions were facilitated with 50 women participating in a professional counterspace (PC) in the U.S., known as the African American Women’s Summit. Participants were asked to explore the following topics: 1) the purposes of PCs for Black women, 2) how PCs can be enhanced with regard to curriculum content and delivery, and 3) how PCs can be enhanced with regard to opportunities for leadership. Findings indicated that Black women in student affairs still need professional development opportunities that allow them to share their collective wisdom, and that are focused on helping them combat isolation and succeed in the profession. In addition, these types of PCs should include a high degree of interactivity among participants, feature a structured curriculum focused on concrete skill and professional competency development, and provide opportunities for prolonged engagement, perhaps even virtually. Finally, the leadership of PCs for Black women in student affairs can be enhanced by engaging in clear and regular communication with participants, maximizing opportunities for leadership among participants, and using technology to facilitate participants’ leadership development.
“Black Women are the Mules of the World”: Black Women Professors of Practice in Teacher Education Programs
Authors: Porcher Kisha Marie , Austin Tasha
Published: June 2023

At the intersection of labor and racial equity in teacher preparation, Black women professors of practice (PoPs) find that they carry an excessive workload without a similar measure of compensation or recognition. The unique experiences of these Black contingent faculty provide a view from the margins regarding the simultaneity (Collins, 2002) of oppressions that are hidden from mainstream perceptions within teacher preparation, particularly through a raced and gendered lens. Through an autoethnographic approach, we reveal how our negotiations for respect, visibility and impact on pre-service teachers are navigated within larger institutional structures situated within the academy. This reflexive process provides us, as research practitioners, a socially conscious pathway (Ellis et al., 2011) towards both impactful practice and means for substantive contributions to investigating the often-hidden labor of Black women professors of practice within post-secondary institutions. While exploring how we were positioned as ‘mules’ of teacher preparation at our previous institution, we amplify experiences that hitherto are alluded to in the literature, thematically reflecting our scarce numbers, low access to professional advancement and lack of job security. We conclude with recommendations both for Black women PoPs about the nature of this work, the reality of its weight, and considerations on behalf of the academy relative to pathways for professionalizing and honoring Black women professors of practice in teacher education programs.
A PROSPECTIVE STUDY OF POST RENAL TRANSPLANT MINERAL BONE DISORDER: A SINGLE CENTER EXPERIENCE
Authors:   Assistant Professor, Depatment of Nephrology, Meenakshi Medical College Hospital & Research Institute, Enathur, Tamilnadu., Kasi Senthilkumar
Published: June 2023

To evaluate sequential changes in biochemical bone parameters, parathyroid hormone (iPTH), and vitamin D levels over a period of 24 weeks after renal transplantation, we studied 52 patients (41 males, with a mean age of 31.98.) who underwent their first renal transplantation without a past history of parathyroid surgery or fractures. Serum calcium, phosphorus, albumin, Serum iPTH and vitamin D levels were measured before transplant, then at 2, 4, 12 and 24 weeks post transplantation. Serum calcium showed a significant increase from 2 to 12 weeks after transplantation, followed by a slight decline until 24 weeks. At the end of 12 and 24 weeks, 6 (11.53%) and 2 (3.8%) patients had hypercalcemia respectively. At the end of 12 weeks only 15.38% (8) patients had hypocalcemia and no patient had hypocalcemia at the end of 24 weeks. Serum phosphorus showed significant decline in the first 4 weeks post transplantation. At the end of 24 weeks 21.2% still had hypophosphatemia. iPTH levels declined rapidly in the first 4 weeks of post transplant period and there after decline slowly till the end of 24 weeks. Baseline iPTH and vitamin D3 levels did not correlate with persistent HPT. Hypovitaminosis D was seen in 16 (30.7%), 8 (15.3 %) and 11 (21.1%) patients at pretransplant, 12, and 24 weeks post transplant respectively. Unlike most studies in literature our patient population experienced lower prevalence of post transplant hypercalcemia, Hypovitaminosis D, and hyperparathyroidism which may have resulted from younger study population and shorter dialysis vintage.
THE HUMAN BRAIN AND A THEORETICAL RESEARCH ABOUT USING THE EEG IN ARCHITECTURE, WITH A PRESENTING OF SOME STUDY CASES
Authors:   Architect. Ph.D., Elborgy Rasha
Published: June 2023

Neuroarchitecture is the way dealing with the design of spaces by studying the relationship between people health and behaviour and buildings with the application of neuroscience. Neuroarchitecture focuses on emotion, happiness, and well-being, which mean it focuses more on people and how they react or feel texture, curves, symmetry, also, the temperature, lighting, colors, scents, and how brains respond to different spaces. It is based on the architectural elements added to a space and have a significant impact on the function of the brain and the nervous system. It is an integration of three fields, namely, neurology, psychology, and architecture. The paper aim to study the human brain and know how is the EEG recording the brain waves, through these waves, we can know the effect of spaces on the brain. With an analytical presentation of some examples in which electroencephalography was combined with the use of spaces.
CLINICAL PROFILE OF HIP FRACTURE IN TERTIARY CARE HOSPITAL: A RETROSPECTIVE ANALYSIS
Authors:   PG Resident, Department of Orthopedics, SRMS Institute of Medical Science, Bareilly, UP., Dagar Abhishek , Shoeb Arif Mohd ,   Assitant Professor, Department of Orthopedics, SRMS Institute of Medical Science, Bareilly, UP.
Published: June 2023

Introduction:The existing literature on the injury patterns of hip fractures in India is sparse, despite the fact that hip fractures are a significant cause of morbidity and mortality in the aged. In order to provide tailored interventions to prevent hip fractures, it is crucial to understand the damage profile of these patients. Methods: This single-center, retrospective study was carried out in 2021â€“2022 by the Department of Orthopaedics at the Shri Ram Murti Smarak Institute of Medical Sciences in Bareilly (UP). 100 patients who had hip injuries. Each patient gave written informed consent and agreed to participate in the trial. During admission, information was gathered through face-to-face interviews with patients and/or their relatives in addition to a review of medical records. Results:The average age was 69.76Â±11.56 years. Of the patients, 59 percent were men, and 41 females (41%) were present. The most common comorbidity was hypertension (56 percent), which was followed by diabetes (33 percent), heart disease (15 percent), cancer (12 percent), and thyroid disease (8 percent). According to the AO fracture classification, fracture type 31A (63%) outnumbered fracture types 31B (26%), and 32 (11 percent). Patients suffered fall injuries in 75% of cases, RTA injuries in 17% of cases, and other injuries in 8% of cases. Conclusion: The most common way of injury for elderly hip fractures, especially in women, is a fall from a standing height. The majority of falls are caused by environmental risks and postural alterations, whereas the majority of RTAs are caused by pedestrian accidents.
A NEW MHEALTH SOLUTION TO IMPROVE POST PARTUM QUALITY OF LIFE «QOL» FOR MOROCCAN WOMEN: A PILOT PROJECT IN MOROCCO
Authors:   Les Orangers Maternity Hospital, Rabat, Morocco., Tijani MD Najlaa , Alami Hassan ,   Les Orangers Maternity Hospital, Rabat, Morocco., Idri Ali ,   ENSIAS, University Mohammed V, Rabat, Morocco., Bezad Rachid ,   Les Orangers Maternity Hospital, Rabat, Morocco.
Published: June 2023

The post partum period also called the puerperium or the fourth trimester is the period following the delivery of the child. It encompasses the 12 weeks after delivery. During this period, mothers facemany challenges due to the need of physicalrecovery fromhormonal and physiological changes. The absence of appropriate and timely postnatal care during this period have dire consequences on both mothers and newborns.Many studies have documented that the use of postnatal care, which has a high prospect for reducing maternal morbidity and mortality, is still suboptimal in Low and Middle income countries such as Morocco. Womens attendance to post partum care visits is low to none in these countries.To improve the quality of post natal care in Morocco, and the quality of life Â« QOLÂ» of our patients, les Orangers maternity hospital collaborated with the software research team of ENSIAS ( national school of computer science) in Rabat in this pilot project to create a post partum QOL based mobile solution( Mamma&Baby app) to help empower and support women in this critical period in their lives, and consequently reduce the mortality and morbidity rates in this patients category.
CLINICAL AND NON-CLINICAL MANAGEMENT IN HEALTHCARE: A COMPREHENSIVE OVERVIEW
Authors:   College of Medicine and Public Health, Flinders University, Adelaide, Australia., Majd Shohreh , Majd Zohreh ,   PsychosomatischeTagesklinik, Passau, Germany.
Published: June 2023

In healthcare settings, the importance of effective management cannot be overstated. It plays a pivotal role in guaranteeing the provision of top-notch care, maximizing resource utilization, and enhancing patient outcomes. This article aims to offer a comprehensive overview of management strategies employed in healthcare organizations, encompassing both clinical and non-clinical aspects. By delving into the roles and responsibilities of healthcare managers, examining clinical management techniques, and emphasizing the significance of non-clinical management practices, we shed light on the criticality of integrating both approaches with the aim of attaining optimal healthcare outcomes through a harmonious blend of clinical and non-clinical management methodologies.
CLINICAL EMPATHY OF MEDICAL STUDENTS
Authors:   Mental Health Research Team, Faculty of Medicine and Pharmacy, CaddiAyyad University, CHU Mohammed VI -Marrakech, Morocco., Hamdaoui A. , Oumoussa A. ,   Mental Health Research Team, Faculty of Medicine and Pharmacy, CaddiAyyad University, CHU Mohammed VI -Marrakech, Morocco., Adali I. ,   Mental Health Research Team, Faculty of Medicine and Pharmacy, CaddiAyyad University, CHU Mohammed VI -Marrakech, Morocco., Manoudi F. ,   Mental Health Research Team, Faculty of Medicine and Pharmacy, CaddiAyyad University, CHU Mohammed VI -Marrakech, Morocco.
Published: June 2023

Empathy is an essential quality for all in their social and family relations, but it becomes more important when it comes to the doctor-patient relationship it is a skill future doctors must master. Our objective was to assess the level of empathy among medical students through the Jefferson scale and highlight the factors influencing empathy and its evolution during medical studies. Our aim was to provide elements to help improve the level of empathy. For the purpose of conducting our research, we asked students from the third to sixth year of medicine at University Hospital Mohammed VI in Marrakech to complete an anonymous questionnaire divided into two sections: personal and socio-demographic information and the Jefferson scale of attitudes of empathy in its French adaptation, which measures clinical empathy in three components.We retained 433 usable questionnaires: 59% of which belonged to female students. The average age was of 22 and the average Jefferson score of 88.69 points. We found that students empathy was associated with gender and that girls showed higher levels than boys. Moreover, we found an association between empathy and financial aid: students with a scholarship were more empathetic. This empathy was also associated with a family history of chronic illness, chronic or personal psychiatric illness the presence of one of these factors makes students more empathetic. However, as the age and academic level of the students increased, the level of empathy decreased. This allowed us to conclude that the levels of empathy among students were declining over time. In conclusion, we discuss the nature of empathy: Is it an innate or learned ability? Can it be taught? Or can it be improved by psychotherapy measures?