bluuebunny/crossref_metadata_2025 huggingface dataset:
试析如何做好建筑施工管理绿色建筑设计的要点内容
Authors: 朱 金平
Published: January 2019

为了促进我国社会经济的长足发展,加强生态建设成为当前发展目标。尤其对建筑行业来说,加强节能减排,控制建筑能耗,对于保护环境,发展绿色经济有着重要作用。本文主要对建筑施工管理中,绿色建筑设计的原则和要点进行详细阐述,旨在全面推动社会主义建设目标的实现。
简议超高层建筑钢结构施工技术要点与安全防护管理
Authors: 秦 飞
Published: January 2019

随着建筑业的快速发展,人们对于建筑需求越来越高,钢结构的各项优势能够满足人们对于超高建筑施工需求,超高建筑的安全性、稳定性的特点,使其除了要根据相应的流程进行施工作业之外,还需要掌握钢结构施工技术,基于此,本文简述了超高层建筑钢结构施工的主要流程,对超高层建筑钢结构施工技术要点及其安全防护管理进行了探讨分析。
建筑项目工程建设的施工现场管理分析
Authors: 张 强 , 朱 连飞
Published: January 2019

施工现场管理对建筑工程建设的顺利实施具有重要作用,其对于保障建筑工程质量具有重要影响,因此为了充分发挥施工现场管理作用,本文阐述了建筑项目工程建设的施工现场管理重要意义及其主要内容,对建筑项目工程建设的施工现场管理措施进行了论述分析。
钢木承插连接法安装木结构杆件施工技术
Authors: 乔 晓月
Published: January 2019

随着我国生态文明建设的快速推进,加上人们对回归自然、提高生活品质的要求越来越高,木结构需求量进一步增加,以木结构作为主体框架,配以幕墙、吊顶等进行精装的现代化木结构建筑在我国取得显著发展,装饰装修工程也对木结构安装的质量提出了更高要求。如何有效提高木结构安装质量是施工单位面临的关键问题。本文结合百色干部学院5#楼木结构建筑,介绍钢木承插连接法安装木结构杆件施工技术,主要对钢木承插连接特点,节点杆件和承插件的处理、定位安装操作要点进行分析,探讨提高木结构安装工程施工质量的有效方法。
试析市政给排水管道工程的施工技术要点
Authors: 李 云嵩
Published: January 2019

在城市建设与发展过程中,市政给排水管道工程建设质量对城市的运转有着十分积极的意义。因此,我们应采取有效措施,保证市政给排水管道工程的施工质量,准确把握市政给排水管道工程的技术要点,确保城市的稳定发展。
道路桥梁工程的常见病害与施工处理技术探究
Authors: 王 启耀 , 付 祥
Published: January 2019

道路桥梁工程的病害极容易造成道路桥梁工程质量下降,潜在的危害还容易诱发交通事故发生,对其进行处理和解决尤为重要。本文就道路桥梁工程的常见病害与施工处理技术进行分析,希望可以为道路桥梁工程质量的提升提供借鉴。
高速公路沥青路面病害分析及处治维修
Authors: 和 龙
Published: January 2019

高速公路是我国交通领域重要的一部分,为我国的经济发展带来了许多便利。高速公路路面主要为沥青混凝土。为了保证沥青路面加铺层的使用寿命,结合路面弯沉检测、钻芯取样及人工徒步调查,分析路面横纵缝、唧浆、龟裂、施工缝开裂、沉陷及桥头跳车等病害产生的原因。而随着交通量的逐渐增多,导致了公路沥青路面出现了各类病害,本文将进行分析,以供参考。
房建工程深基坑施工技术研究
Authors: 覃 科霖
Published: January 2019

深基坑施工质量是保证建筑稳定提高建筑质量的前提和基础,本文对房建工程深基坑施工技术进行研究。
GPS技术在道路桥梁工程测量中的应用
Authors: 夏 玲军
Published: January 2019

GPS技术在道路桥梁工程测量中应用发挥着重要作用,可以有效提高道路桥梁工程建设过程中的测量数据,减少施工中出现的误差。现代道路桥梁工程测量过程中,当遇到地形较复杂且视野不够开阔的施工场地时,不仅阻碍合理安置测量仪器,还会影响道路桥梁工程的施工进度,而GPS技术在道路桥梁工程测量中应用可以使上述问题得到解决。
绿色施工理念在建筑施工管理中的应用解析
Authors: 覃 洁
Published: January 2019

在建筑行业迅猛发展下,城市基础设施不断趋于完善,在促进经济发展的同时,也带来了不同程度上的资源损耗和环境污染。在可持续发展战略提出后,建筑行业首当其中,在建筑施工管理中渗透绿色施工理念十分关键,选择节能环保型材料,在满足建筑工程施工质量和安全需要的同时,尽可能降低能耗和环境污染。本文就建筑施工管理中绿色施工理念应用进行探究,创新实施路径,对于建筑企业市场竞争和发展具有积极作用。
探究高层建筑深基坑支护施工过程的控制要点
Authors: 孔 令军
Published: January 2019

近些年来,我国城市化进程持续推进,城市建筑工程项目的数量也在不断增加,其中多以高层建筑为主。深基坑支护施工技术是高层建筑工程施工中常用的技术类型,本文将对其具体应用进行深入的探索研究,希望可以为建筑行业发展提供助力。
Eficacia de un programa de estimulación de recuerdos emocionales positivos en adultos mayores del medio rural
Authors: Sánchez-Cabaco Antonio , Fernández-Mateos Luz María , Crespo-León Antonio , Schade Nieves
Published: January 2019

INTRODUCCIÓN La necesidad de acometer los retos del envejecimiento poblacional es una tarea que requiere la puesta en marcha de innovaciones y adaptaciones para las poblaciones específicas en los contextos en los que viven los mayores. En este trabajo se intenta dar respuesta a las necesidades particulares de mayores del medio rural en ámbitos residenciales. OBJETIVO Probar la eficiencia de un programa de estimulación que favorezca el recuerdo autobiográfico positivo y el bienestar emocional en adultos mayores del medio rural. MÉTODO Los participantes fueron 15 adultos mayores pertenecientes a 2 residencias rurales, el diseño fue cuasi-experimental, con medidas pre y post intervención, sin grupo de control. RESULTADOS. Se encontró que el programa mejora el estado emocional, provoca un aumento de la felicidad y cognición efectiva. DISCUSIÓN Y CONCLUSIONES Las conclusiones derivadas permiten ser optimistas respecto a la eficacia de este tipo de intervenciones y se discuten limitaciones y alternativas para futuros estudios.
Isolation of Multidrug Resistant Bacteria from Aspirates of Cancer Patients
Authors: Ahsan Sunjukta , Mahmud Rayhan , Ahsan Kajal , Begum Shamima
Published: January 2019

Infections due to Gram-negative bacteria are common affairs in cancer patients during aggressive therapy. The present study characterizedmulti-drug resistant bacteria (MDR) isolated from cancer aspirates collected from patients admitted to the National Cancer Hospital in Dhaka, Bangladesh. A total of 210 aspirate samples were collected from cancer patients. Out of 210 samples Acinetobacter spp.led the list of isolates (8.89%, n=45). Of these species, 50% exhibited resistance to Amoxycillin and Nitrofurantoin, each, 25% exhibited resistant to Cefotaxime, Azithromycin, Ciprofloxacin, Clindamycin, and Sulfamethoxazole. A total of 33.33% of the Bordetella spp.which accounted 6.67%of the total isolates exhibited resistance to Cefotaxime. All oftheLegionellapneumophila,comprising 4.4%of the isolated species, wereresistant to Cefotaxime, Azithromycin, and Clindamycin.In contrast, 50% were resistant to Cefotaxime, Azithromycin, and Ceftriaxone. Of the Escherichia coli(4.4%, n=45) isolated,50% exhibited resistance to Cefotaxime, Clindamycin, Ceftriaxone, Amoxycillinand Sulfamethoxazole.The only isolate of Klebsiella sp. was demonstrated to be an ESBL producer. The isolation of multidrug resistant bacteria from cancer patients is of particular concern in Bangladesh where cancer and drug resistance are both common phenomena but treatment facilities are poor. To our knowledge this is the first report of the isolation of drug resistant bacteria from cancer patients from Dhaka city.

Bangladesh J Microbiol, Volume 35 Number 1 June 2018, pp 61-66
In vivo Anticancer Activity on Ehrlich Ascites Carcinoma (EAC) Cells and in vitro Antimicrobial Activity of Psidium guajava Bark Extracts
Authors: Hossain Md Jakir , Biswas Shashwata , Shahriar Mohammad , Islam Sohidul , Ahsan Chowdhury Rafiqul
Published: January 2019

This study was performed to evaluate the in vivo anticancer activity against ehrlich ascites carcinoma (EAC) cells and in vitro antimicrobial activity of Psidium guajava bark extracts. By soxhlet apparatus, the P. guajava bark extracts were obtained using four solvents (n-hexane, petroleum benzene, chloroform, and methanol) according to their increasing solubility. In case of in vivo anticancer activity of the sample extracts, mice were seeded with approximately 1x105 ehrlich ascites carcinoma (EAC) cells. After seven days of consecutive treatment, the negative and positive control groups (n=8 each group) showed an average EAC cell count of 2.4x108 and 1.8x108 respectively, and the experimental groups showed the cell count of 2.2x 108, 2.1x108, 1.9x108, and 1.41x108 when mice received h-hexane, petroleum benzene, chloroform, and methanol extract respectively. Experimental group that received methanol extract showed percent increase of life span (% ILS) of 33.3 when compared with the negative control. However, treatment in a cyclic manner of the mice showed % ILS of 52.15 for experimental group when compared negative control. In antimicrobial activity experiment, an intermediate zone of sensitivity of the crude methanol extract was found against Escherichia coli, Shigella flexneri, and Staphylococcus aureus when compared with amoxicillin. All these results indicated the anticancer activity and antimicrobial activity of the methanol extract of P. guajava barks on different experimental models.

Bangladesh J Microbiol, Volume 35 Number 1 June 2018, pp 79-81
Implementasi Kebijakan Pengembangan Pariwisata di Pulau Lombok
Authors: Munir Usman , Dimyati Khudzaifah , Absori Absori
Published: January 2019

Lombok is one of the islands of West Nusa Tenggara province with enormous tourism potential, from nature, beaches and culture. So that if this is developed properly it will bring prosperity to the Lombok people in particular and NTB in general. Tourism development policies have not been widely felt to bring effects to welfare to the community. The purpose of this study is to provide an overview of policies and implementation of tourism development policies on tourism on the island of Lombok. Data was collected by observation and interviews. From these data, then analyzed descriptively qualitatively, the data formed becomes a description that describes a situation or event described. Based on the results of the analysis of tourism development policies in Lombok island, it is inseparable from the four tourism pillars contained in regional regulations, namely tourism, marketing, industry and institutional development. The implementation of the policy has not maximally affected the welfare of the people on the island of Lombok, and has even caused new problems in the lower classes.
Pendidikan Agama Hindu Sebagai Dasar Dalam Pembentukan Karakter
Authors: Santika Ni Wayan Ramini
Published: January 2019

Kemajuan IPTEK cenderung menimbulkan perbedaan pandangan antara generasi tua dan generasi muda. Oleh karena itu mempelajari orientasi nilai pada kalangan remaja dan peserta didik, khususnya sikap keberagamannya tentulah penting dilakukan. Pembinaan generasi muda sebagai generasi penerus adalah tanggung jawab bersama antara keluarga, masyarakat bangsa dan negara. Dengan Pendidikan Agama Hindu dapat menjalankan dan mengamalkan ajaran Agama Hindu sehingga terbentuknya budhi pekerti yang luhur dan berakhlak yang mulia. Individu yang memiliki karakter mulia yaitu individu yang memiliki potensi diri seperti yang ditandai dengan nilai-nilai seperti percaya diri, rasional, logis, kreatif dan inovatif, mandiri, bertanggung jawab, sabar, rela berkorban, berpikir positif, disiplin, bersemangat, dinamis, produktif. Di dalam kitab suci Bhagavadgita dinyatakan ada dua kecendrungan yang mempengaruhi karakter manusia, yaitu sifat-sifat ke-devata-an (daivi sampat) dan sifat-sifat keraksasaan (asuri sampat). Kedua kecendrungan ini secara langsung atau pun tidak langsung akan membentuk karakter manusia.
GAME DETEKTIF RESIMEN MAHASISWA BATALYON 209 TEKNOKRAT GAJAH LAMPUNG
Authors: Palendera Yugisman , Fernando Yusra , Rizkiono Sampurna Dadi
Published: January 2019

Game detektif resimen mahasiswa batalyon 209 teknokrat gajah lampung merupakan sebuah game yang diangkat berdasarkan suatu unit kegiatan mahasiswa dengan tujuan untuk memperkenalkan resimen kedalam lingkungan yang lebih luas. Dengan mengetahui game detektif resimen mahasiswa batalyon 209 teknokrat gajah lampung maka pemain dapat menambah wawasan mengenai dampak dan bahaya pungutan liar dan resimen mahasiswa. Teknik pengumpulan data yang dilakukan pada penelitian ini yaitu menggunakan wawancara, tinjauan pustaka, dokumentasi dan kuisioner. Sumber data/subjek yaitu mahasiswa berjumlah 20 orang. Metode pengujian yang dilakukan yaitu aspek Fungsionality dan Usability. Aplikasi game detektif resimen mahasiswa batalyon 209 teknokrat gajah lampung menggunakan metode MDLC (Multimedia Development Life Cycle) tools yang dipakai yaitu Construct 2 yang dijalankan pada Android.Hasil pengujian ISO 9126 kualitas aplikasi game detektif resimen mahasiswa batalyon 209 teknokrat gajah lampung diperoleh nilai dari aspek fungsionality dan usability, dengan variable yang dinilai berupa kriteria Understandability 85%, Learnability 85%, Operability 87%, dan Attractiveness 88%. Untuk persentase secara keseluruhan dari aspek fungsionality dan usability hasil dari pengolahan data pada uji fungsionality dan usability menyatakan bahwa dalam penyebaran datanya sudah berdistribusi secara normal dan Game detektif resimen mahasiswa batalyon 209 teknokrat gajah lampung dapat dijadikan sebagai game dari pernyataan kuisioner yang telah diisi.Kata Kunci: android, construct 2, game detektif, MDLC, ISO 9126.
PARALELISASI NEEDLEMAN-WUNSCH
Authors: Sunarto Asril Adi , Robial Siti Muawamah
Published: January 2019

Peran ilmu komputer diberbagai domain ilmu lain telah banyak membantu dalam memecahkan masalah komputasi seperti dalam microbiologi dalam melakukan proses penjajaran DNA. Salah satu teknik dalam penjajaran urutan DNA adalah Needleman-Wunsch yang menggunakan dynamic programming. Kompleksitas dynamic programming ini mencapai O(n2). Untuk mengurangi kompleksitas tersebut, maka salah satunya dengan menggunakan komputer pararel. Penelitian ini berfokus pada paralelisasi Needlemen-Wunsch dengan menggunakan dua komputer yang saling terhubung dan sampel DNA dari GenBank: D85708.1 dan X51404.1. Tahap pengisian matrik dengan komputer pertama mengerjakan matriks segitiga atas, sisanya dengan komputer kedua. Hasilnya nilai speed up menurun drastis hingga 0.3 dan efisiensi mencapai 15 %. Besarnya kompleksitas komunikasi saat pemrosesan menjadi penyebab menurunnya performa hingga 3 kali lipat lebih lambat dari komputer tunggal. Buruknya nilai speed up dan efisiensi tersebut mengindikasikan bahwa untuk mempercepat metode Needlemen-Wunsch sangat tidak mungkin dan keliru memilih komputer pararel  untuk menjadi suatu solusi.Kata Kunci: bioinformatika, dynamic programming, komputer pararel, needlemen-wunsch, sequence alignment.
Ekonomi Pancasila di Tengah Arus Kapitalisme Pasar
Authors: Umam Syamsul
Published: January 2019

Dalam perekonomian kapitalis setiap warga dapat mengatur nasibnya sendiri sesuai dengan kemampuannya. Semua orang bebas bersaing dalam bisnis untuk memperoleh laba sebesar-besarnya. Semua orang bebas melakukan kompetisi untuk memenangkan persaingan bebas dengan berbagai cara, Pengertian kompetisi dalam moral Pancasila bukan dan tidak sama dengan free fight competition a la barat yang di dalamnya mengandung cara-cara yang boleh merugikan fihak lain (tujuan menghalalkan cara). Hubungan dagang dalam sistem ekonomi Pancasila harus tetap dalam kerangka untuk menjalin tali silaturahmi yang selalu bernuansa saling kasih sayang dan saling menguntungkan, menghindarkan kemuspraan (kesia-siaan). Secara sederhana Ekonomi Pancasila dapat disebut sebagai sebuah  sistem ekonomi pasar dengan pengendalian pemerintah atau ekonomi pasar terkendali. Mungkin ada istilah-istilah lain yang mendekati pengertian Ekonomi Pancasila, yaitu  sistem ekonomi campuran, maksudnya campuran antara sistem kapitalisme dan sosialisme atau sistem ekonomi jalan ketiga dalam bentuk Koperasi. Koperasi sebagai gerakan ekonomi rakyat sebenarnya memiliki potensi besar untuk tumbuh dan berkembang. Kekuatan partisipasi, totalitas, kemandirian dan kesamaan tujuan menjadi modal dasar bagi koperasi untuk bersaing dengan pelaku-pelaku ekonomi lainnya dalam kancah liberalisasi ekonomi. Koperasi yang menganut prinsip gotong royong, kemandirian, keadilan dan kesetaraan hak sesama anggota menempatkan koperasi sebagai aternatif bagi tumbuhnya suatu bentuk perekonomian yang mengakomodir cita-cita masyarakat untuk memperoleh kemakmuran bersama tanpa meninggalkan aspek-aspek solidaritas, hak asasi dan demokrasi.
PENGARUH PEMBERIAN UPAH DAN DISIPLIN KERJA TERHADAP PRODUKTIVITAS TENAGA KERJA PT DUTA TRANS JAYA JAKARTA
Authors: Hidayat Rahmat
Published: January 2019

Organizational performance is the end result of the work done to achieve organizational goals that have been established. All that is determined by the existence of good labor productivity. There are several things that affect the productivity of labor, including the provision of wages and discipline work. One way to reward and acknowledge the existence of manpower is through the provision of wages. In addition to wage factors, labor productivity can also be influenced by work discipline factors. This study aims to determine the effect of wages and discipline of work on the productivity of labor at the company's Duta Trans Jaya Jakarta. The population of the research ani there are 40 employees, so researcher uses saturated samples by using all the popolation. So the sample in this study is 40 people. Based on the above data it can be seen that the value for wage variables, and work discipline (simultaneously) has a significant effect on work productivity, where the significant value of F of 0.000 <0.05 so it can be concluded that Ha accepted and Ho rejected this means that there is A significant influence between wage and work discipline variables on work productivity at PT. Duta Trans Jaya Jakarta.Â Kata kunci:Provision of Wage, Discipline Work, Productivity of worker
KINERJA KARYAWAN PT. SUMBER MAS: PENGARUH GAYA KEPEMIMPINAN DAN MOTIVASI
Authors: Sadeli Inna Nisawati Mardiani
Published: January 2019

A leader as an individual is a personality dealing with a number of other individuals, each of whom is also a personality. The style of leadership and motivation is important in a modern era where the organization demo democracy in the implementation of work and work motivation is good, a result that may arise from a leadership style and poor motivation is a decline in employee performance that will have an impact on total performance decline company. The problems in the review of the above description can be formulated as follows.Is there any influence between leadership style to the performance of employees of PT. Sumber Mas, is there any influence between the motivation on the performance of employees of PT. Sumber Mas, among the variables - style of leadership and motivation which dominant influence on employee performance. Population in this research is all employees of PT. Sumber Mas 93 people, The sample is determined by proportional random sampling technique, with 75 respondents. Data collection methods used are questionnaire (questionnaire) and documentation. The method of analysis used in this research is multiple linear regression analysis method.Based on the results of the research obtained multiple linear regression equation Y = 22.741 + 0.208 + 0.160 , While from the test partial hypothesis (t test) obtained t count from leadership style variables of 3.373T arithmetic motivation variable as much as 2.832 where the probability is smaller than 0.05 then the hypothesis is received. The coefficient of determination (Adjust R2) of 0.324 is the performance of employees of PT Sumber Mas influenced by the style of leadership and motivation, while the rest is influenced by other variables that are outside the variables in the research.Â Keywords:Leadership Style, Motivation, Employee Performance
Comparison of TNF-α and TGF-β Expression in Breast Cancer Tissues-with and without Axillary Lymph Node Metastasis
Authors: Tyasmara Ayu , Sandhika Willy
Published: January 2019

Background: Breast carcinoma dynamics can be seen from the inflammatory mediator produced and some of expressed cytokine mediators mostly found in breast cancer tissues are TNF-α and TGF-β. This research analyzed TNF-α and TGF-β influence in axillary lymph nodes metastasis to prove the role of cytokines in breast cancer dynamics and to be taken as prognosis. Methods: This research used paraffin block of breast carcinoma in various stages of axillary lymph nodes metastasis and TNF-α and TGF-β antibody to observe the expressions. Result: There were significant differences in TNF-α expressions improvement with p < 0.05 in lymph nodes metastasis N1 (13.18%) and TNF-α expressions reduction in lymph nodes metastasis N2 (52.27%) and N3 (27.27%) compared with lymph nodes without metastasis (52.73%). There were no significant differences in TGF-β expressions of all N groups. Conclusion: The result stated that TNF-α cytokines can be used as biomarker independently predicting breast carcinoma prognosis and progressivity. ABSTRAKLatar Belakang: Dinamika karsinoma payudara tercermin dari mediator inflamasi yang dihasilkannya dan salah satu mediator sitokin yang terekspresi banyak pada jaringan tumor payudara adalah TNF-α and TGF-β. Kami menganalisis pengaruh TNF-α dan TGF-β pada metastasis kelenjar getah bening aksila untuk membuktikan peran sitokin dalam dinamika kanker payudara dan untuk dimanfaatkan sebagai alat prognosis. Metode: Penelitian ini menggunakan blok parafin karsinoma payudara pada berbagai stadium metastasis kelenjar getah bening aksila dan menggunakan antibodi TNF-α dan TGF-β untuk mendeteksi ekspresinya. Hasil: Hasil penelitian ini didapatkan perbedaan peningkatan ekspresi TNF-α yang signifikan dengan p < 0,05 pada metastasis kelenjar getah bening N1 (73,18%) dan penurunan ekspresi TNF-α pada metastasis kelenjar N2 (52,27%) dan N3 (27,27%) dibandingkan dengan tanpa metastasis (52,73%). Tidak ada perbedaan signifika n pada ekspresi TGF-β antar semua kelompok N. Kesimpulan: Hasil ini menyatakan sitokin TNF-α dapat dipakai sebagai biomarker untuk memprediksi progresifitas dan prognosis karsinoma payudara secara independen
Expression of γ-H2AX Using Immunofluorescence Assay as an Adaptive Response of PBMC in Radiation Workers at Dharmais Cancer Hospital
Authors: Musthafa Arifin , Djuita Fielda , Kurnia Iin
Published: January 2019

Background: Exposure ionizing of radiation in radiation workers has the potential to cause DNA damage in the form of double strand break as the beginning of genomic instability. DNA damage can be observed with γ-H2AX as the biomarker of DNA double strand breaks (DSBs). The formation of γ-H2AX in the nucleus can occur after radiation exposure of 1 mGy. This study aims to determine the radiation effects in radiation work environments as a study of adaptive responses of peripheral blood mononuclear cell (PBMCs) after radiation by observing γ-H2AX foci expression..  Methods: Blood samples from nine radiation workers and nine non-radiation workers were irradiated with doses 0 Gy, 1 Gy, 1.5 Gy, and 2 Gy. Detection of γ-H2AX foci was done by immunofluorescence assay. The mean of γ-H2AX foci was counted in 50 PBMCs per sample. The comparison mean of γ-H2AX foci was analyzed using tindependent test.  Result: Based on the result study, there were no significant differences in the number of γ-H2AX foci without treatment (p = 0.807). The results of study showed that the formation of 2-3 foci per cell after exposure of 2 Gy increases along with the increasing irradiation doses.  Conclusion: The mean of index of γ-H2AX foci in PBMCs within normal limits between non-radiation workers and radiation workers and level of risk DSBs damage is relatively similar after exposure at doses 1 Gy, 1.5 Gy, and 2 Gy.
Therapeutic Responses of Imatinib and Nilotinib among CML Patients in Hasan Sadikin Hospital Bandung
Authors: Sumantri Agung Firmansyah , Oehadian Amaylia , Wijaya Indra , Vidyaniati Putri , Rahmaniati Rahmaniati
Published: January 2019

Introduction: Chronic Myeloid Leukemia (CML) is a myeloproliferative malignancy with an estimated incidence in the world of 1-2 cases per 100,000 adults. The use of Tyrosine Kinase Inhibitors (TKI) as a therapy for CML is still the first choice for treatment, but some cases show a high level of resistance or intolerance to TKI therapy. This study aims to identify the therapeutic responses of imatinib and nilotinib among CML patients in Bandung.Method: This study is an analytical descriptive study of CML patients at Hasan Sadikin Hospital’s Hematology and Medical Oncology Outpatient Clinic in 2017. The total number of samples in this study is 244 patients, consisting of 199 patients with Imatinib therapy and 45 patients with Nilotinib therapy. The data is processed using SPSS Statistics 22.0 software.Result: The results showed that CML patients had a median age of 42 years, sex ratio of 1: 1 and the highest prevalence was in Bandung City (21.3%). Hematologic response is dominated by complete hematologic response, as high as 72.86% with Imatinib and 66.67% with Nilotinib. Molecular response 3-6 months post therapy is dominated by suboptimal response in as many as 36,8% with Imatinib and failure in as many as 50% with Nilotinib. Molecular response 12-18 months post therapy is dominated by failure in as high as 69,4% with Imatinib and 52,4% with Nilotinib.Conclusion: Based on the molecular response, the rates of suboptimal response and resistance are quite high. Regular monitoring standards of therapy for CML patients are needed to identify TKI resistance so alternative therapies can be provided to improve the outcomes.
Transformasi Budaya Perusahaan Kelompok Kompas Gramedia
Authors: Suparmo Ludwig
Published: January 2019

Within a few decades the leading national daily Kompas, grew in becoming the number one daily in Indonesia. Aside keeping-up with the press advancement, modernizing through its information technology printing and its long distance production has helped its production. The daily-paper then forming several publishing companies, and extending of other media went on, while the bookstores also grew well. However, it then extended into the non core business lines, such as producing and marketing tissue paper and participating in the growing sector of the hotel business. Jakob Oetama, one of the founders was made aware that he would be losing the span of control and at the same time was still much interested in setting a stronger corporate culture based on the company’s ideals which among others are to enlighten the social life and participating in influencing on practicing good governing system. Jakob Oetama who takes the lead always trusted his young dynamic managers, several years ago then, appointed Agung Adiprasetyo as the CEO. The team then formulated the transformation of their corporate culture; not only by establishing a simple way to be easy followed by all the workers: Vision and Mission, that is stated together, but also adding the “5 Cs Values”: Caring, Credible, Competent, Competitive, Customer Delight.
Obyektivitas Televisi Dalam Pilkada Dki Jakarta 2017
Authors: Muhammad Indrabayu , Atmaja Suhendra , Setiyowati Endang
Published: January 2019

Konglomerasi media memang sangat berpengaruh pada isi konten televisi, khususnya pemberitaan. Media massa khususnya televisi memrosesnya dengan  melakukan berbagai macam pembingkaian berita. Pembingkaian terkait dengan bagaimana suatu media mengkonstruksi peristiwa menjadi sebuah realitas berita. Pemahaman individu dan ideologi organisasi adalah faktor utama terjadinya sebuah framing. Tujuan penelitian ini untuk menggambarkan dan menganalisis dua talkshow berita besar di Indonesia dalam membingkai suatu kasus.Paradigma dalam penelitian ini adalah konstruksionis yang bersifat kualitatif deskriptif. Teori yang digunakan ialah Konstruksi Sosial Peter L. Berger & Thomas Luckmann serta teori Hierarchy of Influences dari Pamela J. Shoemaker dan Stephen D Reese (1966) dan teori Semiotika Roland Barthes. Peneliti menggunakan model analisis framing Pan dan Kosicki dengan kerangka konsep obyektivitas. Metodologi yang digunakan dalam penelitian ini adalah Deskriptif Kualitatif dengan analisis data Analisis Framing. Hasil dari penelitian ini adalah talkshow “Mata Najwa” cenderung melakukan framing lebih tegas ke salah satu calon gubernur sehingga terkesan tidak obyektif. Sama halnya dengan “Rosi” yang cenderung lebih dekat dan akrab pada salah satu pasangan kandidat sehingga terkesan tidak obyektif. Kesimpulan dari penelitian ini adalah, masih kurangnya unsur obyektivitas dalam pertelevisian Indonesia, khususnya dalam program informasi, yang seharusnya mengusung unsur obyektivitas dalam menyajikan informasi.
Dampak Media Sosial terhadap Usaha Kecil dan Menengah (UKM) Sentra Industri Keramik Plered, Kabupaten Purwakarta
Authors: Sanggabuwana Danang , Andrini Susi
Published: January 2019

Abstract .The development of social media makes it recommended that social media become the most important part in developing and advancing its business especially in the field of promotion, marketing and marketing as a whole. The existence of today's social media applications has become the most efficient and effective tool for ceramic SMEs in Ceramic Plered Industrial Center, Purwakarta District, and today most of the SMEs have followed the digital era by using social media platform for marketing communications, advertisement, product publicity ceramics and services they provide. They create fan pages for followers to make communication fast, even in different cities or countries SME ceramic actors can warmly welcome advice and opinions that help in improving their business. Based on the review that there is a positive impact although there is also a negative impact of social media applications on the development of business SMEs ceramic entrepreneurs but not undo the intention to advance its business, and motivated to use this platform.Keywords: media, social media
Promosi Penjualan Produk Melalui Instagram
Authors: Ratnasari Anne , Hamdan Yusuf , Julia Aan
Published: January 2019

Wanita pengusaha menjalin hubungan dengan calon konsumen melalui berbagai bentuk komunikasi pemasaran, di mana calon konsumen diberi informasi mengenai produk, dan membujuknya untuk  membeli produk. Salah satu bentuk penawaran kepada calon pembeli melalui media digital online. Berbagai kemudahan ditawarkan dalam penjualan online. Adapun tujuannya antara lain agar dapat meningkatkan antusiasme masyarakat membeli produk. Salah satu media digital online yang digunakan untuk promosi penjualan produk adalah Instagram. Dengan penggunaan media tersebut wanita pengusaha dapat mengaktualisasikan dirinya, karena memiliki aktivitas bisnis, namun sambil mengurus keluarganya. Dengan aktivitas tersebut produk yang ditawarkannya dapat bersaing dengan produk di dalam negeri dan global. Artikel ini merupakan hasil penelitian  yang bertujuan ini bertujuan untuk  menganalisis promosi penjualan yag mencakup kualitas produk, promosi penjualan yang berorientasi konsumen, menjadi sponsor sebuah acara, dan menggunakan Instagram yang penggunaannya dipadukan dengan telepon. Metode penelitian ini kualitatif dengan teknik analisis data berupa studi kasus.Teknik pengumpulan data yang digunakan yaitu observasi, wawancara, dan studi pustaka. Informan penelitian Hasil penelitian  menemukan, wanita pengusaha menerapkan promosi penjualan berupa  produk yang ditawarkan kepada calon konsumen  berkualitas, dengan memperhatikan mutu, ciri, manfaat, model, dan kemasan produk,  menerapkan promosi penjualan yang berorientasi konsumen berupa diskon, dan membagikan produk dalam jumlah kecil,  menjadi sponsor sebuah acara, dan menggunakan Instagram sebagai media informasi kepada calon konsumen.
METAKOGNITIF, PROSES SAINS, DAN KEMAMPUAN KOGNITIF MAHASISWA DIVERGEN DAN KONVERGEN DALAM PBL
Authors: Khery Yusran , Subandi Subandi , Ibnu Suhadi
Published: January 2019

The purpose of this study was: (1) determine differences in metacognitive awareness and cognitive abilities of students who learned with PBL and conventional strategies, (2) determine differences in metacognitive awareness, science process skills, and cognitive abilities among students with divergent thinking and character convergent strategies are learned with PBL. This study uses three different kinds of design that is descriptive research design, quasi-experimental design, and pre-experimental design to answer the research objectives numbered one through three in a row. The instrument used in this study were: (1) questionnaire divergent thinking and convergent character, (2) metacognitive awareness questionnaire, (3) observation sheets science process skills, and (4) tests of cognitive ability. Data were analyzed by inferential statistics. The results showed that: (1) there is no difference in metacognitive awareness and cognitive skills of students with learning strategies derived from PBL and conventional strategies, (2) there are no differences in metacognitive awareness and cognitive abilities among students divergent and convergent. Science process skills students better than the divergent-convergent.
PENGARUH PEMBELAJARAN SAVI BERBASIS MEDIA SIMULASI INTERAKTIF TERHADAP KETERAMPILAN BERPIKIR KRITIS MAHASISWA PADA MATERI ELEKTROKIMIA
Authors: Dewi Citra Ayu , Ahmadi Ahmadi
Published: January 2019

Characteristics of electrochemical material that contains abstract concepts. Hence often have difficulty in teaching it. An effective approach as a solution is the SAVI-based interactive learning approach of interactive simulation. Learning SAVI-based interactive media has an animation program that is able to represent abstract concepts in electrochemical materials through visualization and not illustration of the concept in narrative. The purpose of this research is to know the influence of SAVI learning approach to students' critical thinking skill in electrochemical material. The type of research used is quasi-experimental research. The research design used is posttest only control group design. The sample was divided into two groups: experiment and control group. The research instrument uses critical thinking skill test through rubric. The results show that the SAVI approach has a positive effect on critical thinking skills compared to conventional methods. We conclude that the SAVI learning approach has been able to improve students' critical thinking skills.
PENGEMBANGAN PERANGKAT PEMBELAJARAN BERBASIS CTL PADA MATERI POKOK CAHAYA UNTUK MENINGKATKAN PRESTASI BELAJAR SISWA KELAS VIII SMP N 1 KURIPAN
Authors: Yunita Erni , Wahyudi Wahyudi , Rahayu Satutik
Published: January 2019

The aims of this research is to develop CTL based instructional instrumenton light conceptand to know the effect of CTL based instructional instrument’sapplication to increase eighth years student physics achievement. The design is a quasi-experimental research and used R&D method. Research subject was eighth years students at Junior High School 1 Kuripan. Datawere analyzedusingttestatsignificant level5%. The average value ofN-Gain obtainedthrough pretestandposttest data. This indicatesthat theapplication of CTL based instructional instrument on light concept has a positive effecttoincrease eighth student physics achievement.  So that CTL Based Instructional Instrument can be developedmore widely
MENINGKATKAN KESADARAN METAKOGNITIF DAN HASIL BELAJAR SISWA MELALUI PENERAPAN PEMBELAJARAN PROBLEM SOLVING
Authors: Sukaisih Roniati , Muhali Muhali
Published: January 2019

The purpose of this study is to increase metacognitive awareness and student learning achievement through the implementation of Problem Solving learning. Learning achievement in this study include the cognitive, affective, and psychomotor aspects on temperature and heat learning material. This study used Classroom action research conducted in 3 cycles consisting of planning, implementation, observation, evaluation, and reflection. Students' metacognitive awareness data obtained through metacognitive awareness questionnaire and students' activity in worksheet used to control Students' metacognitive awareness. Student learning achievement was taken with multiple-choice test techniques for cognitive learning achievement, practicum activities and presenting practicum results for affective and psychomotor learning achievement tailored to affective and psychomotor indicators. The conclusion of this research is through the implementation of Problem Solving learning can increase metacognitive awareness and student learning achievement.
PENGEMBANGAN PERANGKAT PEMBELAJARAN IPA BERBASIS TOLERANSI UNTUK DAERAH RAWAN KONFLIK
Authors: Muliadi Agus , Arjun Mursalin Arifin
Published: January 2019

West Nusa Tenggara has been inhabited by three major tribes namely; Sasak in Lombok, Samawa, in western Sumbawa, and Mbojo tribe in the middle and east of Sumbawa Island. Other tribes in Indonesia such as Bali, Java, Medan, and others color the cultural diversity of the people of West Nusa Tenggara (NTB). The blending of various characters, cultures, and customs in a community of life is very potential to cause tribal, religious, belief, and racial conflicts. This fact occurs because of the lack of tolerance in the community. Tolerance can be built through well-planned education. This study aims to: 1) know the model of 'learning devices' IPA based on tolerance for school / madrasah in conflict prone areas, 2) to know the ability of science teachers in applying learning tools IPA based on tolerance, 3) to know the social skills of students in science learning, 4 ) know the attitude of student's tolerance after learning, 5) knowing student cognitive learning outcomes after science-based learning tolerance. The research used is research development with model development of Kemp et al. (1994). This research was conducted in two stages, namely: (1) Development of Learning Device which includes; (a) Instructional Problems, (b) Learner Characteristics, (c) Task Analysis, (d) Objectives, (e) Content Sequencing, (f) Instructional Strategies, (g) Instructional Delivery, (h) Evaluation Instrumens, ) Instructional Resources. (2) Testing Devices to be implemented on the students of class IX MTs Kondok Barokah Nahdlatul Wathan. Research data were analyzed using descriptive statistics by calculating descriptive statistic parameters, such as; the highest value, the lowest value, the average, standard deviation, and percentage.
PENGARUH INTEGRASI NILAI-NILAI IMTAQ PADA MATERI STRUKTUR ATOM TERHADAP MOTIVASI DAN KARAKTER RELIGIUS
Authors: Khatimah Nurhusnul , Khaeruman Khaeruman , Khery Yusran
Published: January 2019

Lack of awareness of: courtesy, dishonesty while performing individual tasks, being dishonest in daily tests, and not being obedient to the teacher's instructions is due to the lack of Imtaq process. To solve it is by integrating Imtaq values with learning materials. This study aims to determine the effect of integration of Imtaq values on the material of atomic structure to motivation and religious character. The research was conducted in class X MAN 1 Mataram during August until September 2014. The subjects of the study were students of class X IPA-2 (as experiment) and X IPS-3 (as control) were 37 and 39 students respectively. This research is a quasi- experiment with posttest-control group design. Data of research result are motivation and religious character. The instrument of data collection is a questionnaire of motivation and questionnaire of religious character which has been tested its validity and reliability on 76 subjects who have the same characteristics of age and level of education with the subject of research. The data were analyzed using normality test followed by kolmogorov-smirnov test. The results showed that there is an effect of integration of imtaq values on the material of atomic structure to motivation and religious character.
ANALISIS VEGETASI HUTAN TAMAN NASIONAL GUNUNG RINJANI RESORT JOBEN KABUPATEN LOMBOK TIMUR
Authors: Subagio Subagio
Published: January 2019

This research was aimed at analyzing the forest vegetation of National Parkin Rinjani Mountain for developing plant ecology practicum guide. This research was pure research with descriptive explorative design. This research was donein Resort Joben, Rinjani Mountain.The sample that were used in this research was taken based on the area by using area sampling technique. The data collection were analyzed by using Mullerand Dombois Ellenberg theories. Based on the analysis of the data collection, it was found that there were 44 plant sin 3 level sin individual class ifying which 34 type sofs take with KlokosUdang were dominated, 37 type sofmast with Lembokek were dominated and 23 type softree with Dadap were dominated. Based on the observation and analysis of the data in Resort Joben, Rinjani Mountain, it was found that 34 type sofs take with 238 units; 37 type sofmast with 166 units; and 23 type soft tree with 357 units, there fore the total number of regeneration level was 44 types with 761 units. The highest level of Important Value (IV) index was type sof mast which was 294.1. There sult of validity from practicum guides was shown that the mean score was 3.07 with good category. According to the finding sand discussion of this research, it can be concluded that there is some vegetation type sof National Parkin Resort Joben, Rinjani Mountain, and according to the result of practicum guide validity, it was shown that the result of this research was feasible and in good category
Pengaruh Media Presentasi dan Komik dalam Pembelajaran Biologi terhadap Hasil Belajar ditinjau dari Motivasi Siswa
Authors: Marwatoen Fatmi
Published: January 2019

This research is experimental research which aims to find out: 1) the effect of using presentation media and comics on student biology learning outcomes; 2) the influence of high and low motivation on student biology learning outcomes; 3) the interaction between media usage and motivation towards biology learning outcomes. This study uses Factorial 2 x 2 design, using a population of 123 students consisting of 4 (four) classes held at SMAN 8 Mataram, in the academic year 2012/2013. Data analysis using two-way ANOVA with the help of SPSS 17 for Windows. The results of this study indicate that: 1) there is an influence of media use on student biology learning outcomes (p> 0.05); 2) there is no effect of high and low motivation on student biology learning outcomes (p <0.05); 3) there is no interaction between the use of media and motivation towards biology learning outcomes (p> 0.05).
Problem-Based Learning melalui Belajar Kooperatif Think-Pair-Share untuk Meningkatkan Pemahaman Konsep Mahasiswa Calon Guru
Authors: Muzaki Ahmad , Purwanto Purwanto , Karim Muchtar Abdul
Published: January 2019

This study aims to describe the PBL process through cooperative TPS learning so that it can improve the understanding of fourth-semester students of the IKIP Mataram Mathematics Education Department on integer division. This study was a classroom action research (CAR) which was applied to 44 fourth semester students of the mathematics education study program IKIP Mataram. The instruments of data collection included lecturer and student activity sheets, tests, interview guidelines, field notes, and documentation. The criteria of success in this study are based on (1) data on observations of student activities. (2) observational data on lecturer activity, and (3) test results data. The results of the first cycle showed that (1) the observational data of student activities were in the fairly active category, (2) the results of lecturer activity observation data were in a fairly good category, and (3) the average score of student test results was less than 68. The results of the research in the second cycle showed that (1) the observational data of student activities were in the active category, (2) the observation data of lecturers' activities were in the good category, and (3) the average score of student test results was more than or equal to 68 Cycle II, all the success criteria have been achieved, so that the application of PBL through TPS cooperative learning can improve the understanding of integer division material in fourth semester students G mathematics education study program IKIP Mataram academic year 2011/2012.
Validitas Buku Ajar Ekologi Berbasis Kearifan Lokal untuk Mengembangkan Sikap Ilmiah Mahasiswa
Authors: Hunaepi Hunaepi , Firdaus Laras , Kurnia Nova
Published: January 2019

This study aims to describe the validity of local wisdom-based ecology teaching books to develop students' scientific attitudes. This research is a qualitative descriptive study to assess and obtain a valid ecological textbook in developing the students' scientific attitudes. Ecology textbooks are validated by 4 (four) validators. The results of the study indicate that; 1) the validator's assessment of textbooks developed from aspects of content validity and construct validity is categorized as valid with a range of scores ˃ 3.6 with reliability for each component having a percentage agreement of ˃ 75%. This shows that local wisdom-based ecology teaching books are valid and can be used in learning activities.
Literatur Reviu Keterampilan Proses Sains sebagai Dasar Pengembangan Keterampilan Berpikir Tingkat Tinggi
Authors: Asy'ari Muhammad , Fitriani Herdiyana
Published: January 2019

This article aims to describe empirically and theoretically the role of science process skills as a basis for learning high-level thinking skills. Science process skills are skills that are able to answer the demands of learning in accordance with the principles of constructivism related to the nature of science learning which is divided into three categories, namely (1) basic science process skills, (2) intermediate science process skills, and (3) science process skills high. Science process skills are claimed by many experts as the basis for developing high-level thinking skills. Activities such as (1) observation allow a person to be open to inquiry and be sensitive and willing to observe, (2) comparison, (3) classification, (4) measure, (5) communication, (6) inference, (7) prediction , (8) hypotheses, and (9) define and control variables, are activities in science process skills that are indispensable as basic skills to be able to think higher through integration in the learning process. High-level thinking skills such as critical thinking, creative thinking, and problem solving can be built through science learning that emphasizes the process. Critical thinking skills which are reflective processes in analyzing and evaluating information to determine one's beliefs and behavior can be built through creative processes that are lues, flexible, original, and precise in the stages of problem solving identification, planning, implementation and reflection.
Pengembangan Worksheet Berorientasi Guided Inquiry untuk Membentuk dan Melatih Habits of Mind Mahasiswa
Authors: Masiah Masiah , Adawiyah Siti Rabiatul
Published: January 2019

This study aims to develop a guided inquiry that is valid and effective so that it can shape and train students' habits of mind. This research is research and development (R & D) with steps; observation of potential problems, product design, design validation, limited scale trials, product design revisions, large-scale trials. Worksheet validation is done by 2 validators with 4.2 validation results with a valid category. The results of the study on the implementation test on 12 students showed the results of the N-Gain test of 0.73 with high categories and the habits of mind of students assessed through questionnaires had an average score of 74.5 in the good category. The results of the habits of mind observation of students showed an increase from the first meeting to the last meeting. Based on the results of the study it can be concluded that guided inquiry-oriented guided inquiry development is valid and effective to train and form the habits of mind of students. Research findings also indicate a positive correlation between habits of mind and student learning outcomes.
Association between GPs’ suspicion of cancer and patients’ usual consultation pattern in primary care: a cross-sectional study
Authors: Jensen Henry , Merrild Camilla Hoffmann , Møller Henrik , Vedsted Peter
Published: January 2019

Background

Patients who rarely consult a GP in the 19–36 months before a cancer diagnosis have more advanced cancer at diagnosis and a worse prognosis. To ensure more timely diagnosis of cancer, the GP should suspect cancer as early as possible.

Aim

To investigate the GP’s suspicion of cancer according to the patient with cancer’s usual consultation pattern in general practice.

Design and setting

A cross-sectional study based on survey data from general practice of 3985 Danish patients diagnosed with cancer from May 2010 to August 2010, and linked to national register data.

Method

Using logistic regression analysis with restricted cubic splines, the odds ratio (OR) of the GP to suspect cancer as a function of the patient’s number of face-to-face consultations with the GP in the 19–36 months before a cancer diagnosis was estimated.

Results

GPs’ cancer suspicion decreased with higher usual consultation frequency in general practice. A significant decreasing trend in ORs for cancer suspicion was seen across usual consultation categories overall (P<0.001) and for each sex (males: P<0.05; females: P<0.05). GPs’ cancer suspicion was lower in patients aged <55 years in both rare and frequent attenders compared with average attenders.

Conclusion

GPs suspect cancer more often in rare attenders ≥55 years. GPs’ cancer suspicion was lower in younger patients (<55 years), in both rare and frequent attenders. GPs should be aware of possible missed opportunities for cancer diagnosis in young attenders and use safety netting to reduce the risk of missing a cancer diagnosis.