bluuebunny/crossref_metadata_2025 huggingface dataset:
Monismo, relaciones, y los límites de la explicación metafísica
Authors: Briceño Sebastián
Published: June 2021

Resumen: En este artículo pretendo explorar los límites de una concepción de explicación metafísica basada en el Principio de Razón Suficiente (PRS). Para ello me concentraré en una de las consecuencias contraintuitivas que supuestamente se siguen de una aplicación irrestricta del PRS, a saber: el Monismo Radical. Primero, articularé dicha concepción de explicación metafísica. Luego, explicaré cómo es que de un famoso argumento que descansa sobre el PRS (el regreso de Bradley) parece efectivamente seguirse el Monismo Radical. En seguida, argumentaré en contra de la natural reacción frente a dicho argumento, a saber: aceptar el pluralismo y las relaciones como hechos brutos últimos. Finalmente, esbozaré una versión cualificada del PRS, PRS*, que nos permite sortear el Monismo Radical sin necesidad de renunciar al contenido esencial del PRS.
Autologous platelet-rich plasma action on skin autografts in horses
Authors: Pedroso Ana Carolina Barros da Rosa , Queiroz Ana Kellen Lima de , Brito Eric Saymon Andrade de , Souza Joel Phillipe Costa e , Miguel Marina Pacheco , Brandstetter Luciana Ramos Gaston , Moura Veridiana Maria Brianezi Dignani de
Published: June 2021

ABSTRACT: This study evaluated the action of autologous platelet-rich plasma (PRP) on cutaneous wounds, containing skin autografts, in the gluteal region of horses. Seven healthy horses were used. Two 6 x 6cm cutaneous wounds were produced on each side of the gluteal region. Eight days after wound induction, grafts were performed with skin fragments harvested from the neck, as well as the application of PRP, prepared by double-centrifugation protocol. Wounds with autografts on the left side received PRP (group T), and those with autografts on the right side did not receive treatment (group C). Macroscopic and microscopic evaluations were performed, considering the integration of autografts and retraction of wound edges, as well as neovascularization, inflammatory infiltrate, young fibroblasts, collagenization, reepithelization and autografts integration. There was no difference between the groups (P > 0.05) in relation to most macroscopic and microscopic variables. However, neovascularization was significantly greater (p = 0.0191) in group T, on the 14th day after grafting. It is concluded that PRP favors the process of skin repair with autografts in horses, since it increases the neovascularization in the initial phase of wound healing. Furthermore, the PRP seems to positively influence the integration of the skin autografts and the retraction of the wound edges.
A construção de currículos narrativos mediados pelas tecnologias: um olhar para a formação de professores e as narrativas digitais de aprendizagem
Authors: Rodrigues Alessandra , Almeida Maria Elizabeth Bianconcini de
Published: June 2021

RESUMO Este artigo apresenta um estudo sobre a utilização de narrativas digitais de aprendizagem em contexto de formação de professores. Como dados empíricos, são analisados discursos de mestrandos(as) produzidos em uma disciplina de um Programa de Pós-Graduação em Ensino de Ciências (Mestrado Profissional) de uma universidade pública brasileira, buscando indícios de construção do currículo narrativo a partir da produção e veiculação de narrativas digitais de aprendizagem elaboradas como atividade curricular. A recolha de dados compreendeu o acompanhamento da disciplina (estruturada por meio de encontros presenciais e atividades realizadas em ambiente virtual) e a realização de dois grupos focais com os sujeitos da investigação. As análises dos dados tiveram como inspiração a Análise de Discurso e utilizaram o software NVivo como suporte para a composição do corpus. O estudo indica as narrativas digitais de aprendizagem como um dos caminhos para a construção do currículo narrativo, proposto por Ivor Goodson, uma vez que são espaços profícuos para o reconhecimento da experiência dos sujeitos em articulação com os conteúdos curriculares incitando a ecologia de saberes. Assim, propõe que o uso de narrativas digitais de aprendizagem pela perspectiva do currículo narrativo pode ser entendido como uma possibilidade didático-metodológica para a formação de professores.
O olhar complexo sobre a formação continuada de professores para a utilização pedagógica das tecnologias e mídias digitais
Authors: Santos Taís Wojciechowski , Sá Ricardo Antunes de
Published: June 2021

RESUMO O presente artigo apresenta os resultados de uma pesquisa de doutorado que teve por objetivo caracterizar, descrever, analisar, compreender e contrastar como se organizam os programas de formação continuada de professores em tecnologias e mídias digitais (TMDs), atuantes nas séries iniciais do Ensino Fundamental. A partir de uma abordagem qualitativa foi realizado um estudo de caso múltiplo, nos programas de formação continuada em TMDs propostos pelas Secretarias Municipais da Educação (SMEs) dos municípios de Curitiba (PR), Cascavel (PR), Florianópolis (SC) e Joinville (SC). Os dados foram obtidos por meio de entrevistas semiestruturadas, questionários e análise das diretrizes e currículos norteadores das ações educacionais destes quatro municípios. A análise e a compreensão do processo deram-se à luz dos pressupostos teóricos do Pensamento Complexo, de Edgar Morin. Os principais resultados obtidos com este estudo indicam: a relevância do protagonismo docente nos processos formativos; a necessidade de realização da formação in loco, na unidade de atuação dos professores; a importância de um acompanhamento, assessoramento e auxílio para que os docentes coloquem em prática os conteúdos desenvolvidos nas formações; a necessidade de infraestrutura adequada, com aquisição e manutenção de recursos digitais; e a pertinência da formação continuada de professores não ser desenvolvida de forma isolada, mas compreendida como uma tecitura de múltiplos elementos que precisam ser considerados, para que as práticas formativas em TMDs possam contribuir para o processo de qualificação docente.
A Pesquisa-Intervenção no Mestrado Profissional e suas possibilidades metodológicas
Authors: Costa Daianny Madalena , Ghisleni Ana Cristina
Published: June 2021

RESUMO A pesquisa-intervenção é apresentada na dimensão da especificidade que assume na proposta de um Mestrado Profissional. Ao aproximar propostas de intervenção construídas pelas dissertações do Programa de Pós-Graduação em Gestão Educacional – Mestrado Profissional da Unisinos de elementos retirados de revisões bibliográficas pautadas por diferentes autores, o objetivo é discutir a importância e a configuração das propostas de intervenção em suas dimensões de compromisso ético, social e epistemológico. Evidencia-se, com isso, um percurso de amadurecimentos e de desafios no que tange à constituição de uma metodologia atrelada a um campo de conhecimento que se robustece mais ainda o que está em construção.
História e memória do Programa de Pós-Graduação em Educação da Universidade Federal do Paraná (1975-2020)
Authors: Bencostta Marcus Levy , Campos Marília Andrade Torales , Machado Júnior Cláudio de Sá
Published: June 2021

RESUMO Este ensaio trata de um registro de memória que se soma às celebrações dos 45 anos de funcionamento do Programa de Pós-Graduação em Educação (PPGE) da Universidade Federal do Paraná (Brasil). Trata-se, portanto, de uma narrativa escrita a seis mãos, cujo objetivo é narrar e promover uma reflexão sobre os momentos importantes que marcaram profundamente a experiência histórica e a contribuição acadêmica que este Programa de Pós-Graduação acumulou ao longo de quatro décadas e meia na formação de mestres e doutores em Educação. Para compor a trama de dados sobre a história do PPGE, foi feita uma revisão de documentos como: os relatórios anuais (1975-2020), as atas de reunião do colegiado e os textos já publicados sobre a trajetória do Programa. A narrativa, feita por professores que atuam no PPGE, buscou descrever três períodos definidos a partir de uma cronologia marcada pelas fases de criação, consolidação e prospecção do Programa. A partir desta revisão histórica, foi possível destacar elementos que permitem compreender a história do PPGE nos contextos nacional e regional resguardando suas singularidades, bem como apontar linhas e tendências para sua futura evolução.
Frequency of alleles associated with celiac disease in patients with autoimmune thyroid disease
Authors: SILVA Clédia Silveira Flores da , CARDOZO Natalia Rodrigues , ZANATTA Raíssa , SCHNEIDER Augusto , BARROS Carlos Castilho de , BOTELHO Fabiana Torma
Published: June 2021

ABSTRACT Objective To determine the frequency of Human leukocyte antigen alleles and to verify the association of the presence of these alleles with symptoms and other diseases related to celiac disease in patients with autoimmune thyroid diseases. Methods A questionnaire on the symptoms and diseases associated with celiac disease was applied. Genomic deoxyribonucleic acid was extracted by collecting cells from the oral mucosa. The alleles (DQA1*0501; DQB1*0201; DRB1*04) were identified by means of the polymerase chain reaction. Results A total of 110 patients with autoimmune thyroid diseases participated in this study. It was observed that 66.4% of the individuals carried at least one of the alleles assessed and that 58.2% of the individuals were positive for at least one of the DQ2 alleles (DQA1*0501; DQB1*0201) and out of these 18.2% were positive for both DQ2 alleles (DQA1*0501; DQB1*0201). With regard to DQ8 (DRB1*04), 21.8% of the studied population was positive for this allele and 3.6% was positive for both DQ2 (DQA1*0501; DQB1*0201) and DQ8 (DRB1*04). A significant association was found between the presence of the DRB1*04 allele and gastrointestinal symptoms (p=0.02). A significant association of the DRB1*04 allele with type 1 diabetes mellitus (p=0.02) was observed. Conclusion The genetic profiles most commonly associated with celiac disease, such as DQ2 (DQA1*0501; DQB1*0201) and DQ8 (DRB1*04) were around 20.0% prevalent in the studied population. These are risk haplotypes for celiac disease especially when symptoms and diseases related to celiac disease are present. Therefore, it is important to screen patients to investigate a potential diagnosis for celiac disease.
”Hunger and rage (and the virus) are human things”: reflections on solidarity in times of Covid-19
Authors: OLIVEIRA Juliana Theodora Cunha de , CAMARGO Anice Milbratz de , MACHADO Beatriz Oliveira Blackman , OLIVEIRA Anelise Rizzolo de , FIATES Giovanna Medeiros Rataichesck , VASCONCELOS Francisco de Assis Guedes de
Published: June 2021

ABSTRACT Objective To identify and reflect about civil society’s initiatives to curb hunger in connection with the Covid-19 pandemic in Brazil. Methods In order to identify society’s initiatives to fight hunger, two independent systematic searches were conducted in the Google® search engine using the following keywords: “covid civil society initiatives” and “hunger pandemic solidarity campaign”. Results Fourteen nationwide civil society-promoted initiatives were identified, that among their objectives aimed at fostering collective funding to purchase and distribute foods. Conclusion Brazilian society has been historically sensitive to the hunger problem and shows solidarity as a social value. Nevertheless, the State is legally bound to provide food, as a social right.
EFEITO DE EXTRATOS DE ARISTOLOCHIA LAGESIANA (ARISTOLOCHIACEAE) SOBRE A LAGARTA-DA-SOJA, ANTICARSIA GEMMATALIS (LEPIDOPTERA: NOCTUIDAE)
Authors: Vieira L. , Pascoli I. De , Bortoli S.A. De , Lopes L.M.X.
Published: June 2021

RESUMO Vários relatos de atividades biológicas podem ser encontrados nas espécies de plantas pertencentes ao gênero Aristolochia (Aristolochiaceae), cujas plantas estão distribuídas em todo o território nacional. Visando a obtenção de mais informações sobre essas plantas, avaliou-se a ação de extratos de Aristolochia lagesiana Ule. var. intermedia Hoehne sobre Anticarsia gemmatalis Hüebner, 1818 (Lepidoptera: Noctuidae). O experimento foi conduzido no Laboratório de Biologia e Criação de insetos da FCAV/ UNESP – Jaboticabal e no Laboratório de Química Orgânica do IQ/ UNESP – Araraquara. A toxidade relativa dos extratos foi determinada através da aplicação tópica de uma gota de 1 µL de solução, de cada extrato, que foi aplicada no mesotórax de lagartas de terceiro instar, utilizando-se um aparelho microaplicador. As plantas foram extraídas em acetona, que foi evaporada antes da aplicação e, para isto, os extratos foram re-solubilizados em etanol para obtenção das seguintes dosagens: 6,0; 9,6; 13,2; 16,8; 20,4 e 22,0 mg/?L. Os extratos de A. lagesiana alongam a duração do período larval, reduzem o peso de pupas e também diminuem a viabilidade larval de A. gemmatalis .
AVALIAÇÃO DA QUALIDADE SANITÁRIA DE INCUBATÓRIO POR MEIO DE PLACAS DE SEDIMENTAÇÃO
Authors: Cardoso A.L.S.P. , Tessari E.N.C. , Kanashiro A.M.I. , Stoppa G.F.Z. , Luciano R.L. , Castro A.G.M.
Published: June 2021

RESUMO O setor avícola brasileiro atingiu, graças ao avanço tecnológico e à competência dos profissionais ligados ao setor, o posto de maior exportador e segundo maior produtor mundial de carne de frango. Estes métodos incluem a questão de contaminação do ambiente por micro-organismos patogênicos que podem trazer perdas produtivas na cadeia avícola como um todo. O objetivo do presente trabalho foi avaliar as condições microbiológicas de um incubatório do Estado de São Paulo. A metodologia empregada foi a da técnica da placa de sedimentação com meios de cultura específicos para o crescimento de bactérias e de fungos. Foram realizados 30 monitoramentos, expondo-se as placas de Petri com dois meios de culturas diferentes, ágar Mac Conkey e ágar Sabouraud dextrose. Observamos que os índices de contaminação fúngica e bacteriana não foram elevados nos locais onde as placas foram expostas, exceto na máquina de vacinação onde o número de enterobactérias foi 52,7 unidades formadoras de colônias (UFC). Podemos concluir que o método de contagem de colônias fúngicas e bacterianas pode ser uma maneira simples de monitorar a eficiência sanitária do incubatório.
Effect of biodegradable coatings on the shelf life of Hancornia speciosa
Authors: Felicio Naiara Tays Francisco , Ferreira Suzane Martins , Oliveira Taysa Martins de , Moraes Emmerson Rodrigues de , Soares Dayana Silva Batista
Published: June 2021

ABSTRACT The production of Hancornia speciosa Gomes, in Brazil, has increased significantly in recent years, with a concomitant increase in post-harvest losses, making it important to find out new techniques that contribute to extend the shelf life of this fruit without altering its physical, sensory and nutritional characteristics. The present study aimed to apply biodegradable coatings made from chitosan, whey protein, lactic acid and cassava starch to H. speciosa, as well as to assess their efficiency on the shelf life of the fruits. For that, physico-chemical analyses were performed to determine the pH, acidity, ºBrix, phenolic compounds, vitamin C and moisture content. The coatings with 1 % of chitosan, 4 % of whey protein, 3 % of cassava starch and 1.5 % of lactic acid presented satisfactory results at ambient temperature (25 ºC), delaying the ripening process, when compared to the controls.
Pre-germinative treatments applied to Chionanthus pubescens and C. virginicus seeds for sexual propagation
Authors: Romero Mario José Añazco , Mediavilla Brayan Steven Haro , Pantoja María Isabel Vizcaíno
Published: June 2021

ABSTRACT Chionanthus pubescens Kunth and C. virginicus seeds present double dormancy, what represents a problem for their sexual reproduction, given that it prevents them from reaching adequate germination rates. This research aimed to apply pre-germinative treatments to overcome the double dormancy in C. pubescens and C. virginicus seeds, as well as to improve both the germination speed and the amount of obtained seedlings. A completely randomized design was applied, with four treatments for each species (soaking seeds in cold water, soaking seeds in hot water, mechanical scarification and control) and three replications. For C. pubescens, the pre-germinative treatment with the best results was mechanical scarification, with a 39.22 % germinative capacity; while, for C. virginicus, the best treatment was soaking seeds in hot water (49.00 %).
Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery
Authors: Buscher Konrad , Heitplatz Barbara , van Marck Veerle , Song Jian , Loismann Sophie , Rixen Rebecca , Hüchtmann Birte , Kurian Sunil , Ehinger Erik , Wolf Dennis , Ley Klaus , Pavenstädt Hermann , Reuter Stefan
Published: June 2021

Significance Statement

Big data approaches are considered important tools to dissect immune responses during kidney transplantation. This study demonstrates that large omic data, molecular phenotyping, and unsupervised machine learning offer deeper insight into disease states compared with conventional histology. The resulting data-driven immune framework can lead to optimized patient stratification in clinical trials, biomarker discovery, and personalized medical approaches.

Background

In transplant medicine, clinical decision making largely relies on histology of biopsy specimens. However, histology suffers from low specificity, sensitivity, and reproducibility, leading to suboptimal stratification of patients. We developed a histology-independent immune framework of kidney graft homeostasis and rejection.

Methods

We applied tailored RNA deconvolution for leukocyte enumeration and coregulated gene network analysis to published bulk human kidney transplant RNA transcriptomes as input for unsupervised, high-dimensional phenotype clustering. We used framework-based graft survival analysis to identify a biomarker that was subsequently characterized in independent transplant biopsy specimens.

Results

We found seven immune phenotypes that confirm known rejection types and uncovered novel signatures. The molecular phenotypes allow for improved graft survival analysis compared with histology, and identify a high-risk group in nonrejecting transplants. Two fibrosis-related phenotypes with distinct immune features emerged with reduced graft survival. We identified lysyl oxidase-like 2 (LOXL2)–expressing peritubular CD68+ macrophages as a framework-derived biomarker of impaired allograft function. These cells precede graft fibrosis, as demonstrated in longitudinal biopsy specimens, and may be clinically useful as a biomarker for early fibrogenesis.

Conclusions

This study provides a comprehensive, data-driven atlas of human kidney transplant phenotypes and demonstrates its utility to identify novel clinical biomarkers.
Do obstetric factors have an effect on success of medical treatment of anal fissure seen in women?
Authors: BOLAT Hacı , ÇAKMAK Bülent
Published: June 2021

Objective: The aim of this study is to examine the effect of obstetric factors on the medical treatment success of anal fissure in women.

Material and methods: A total of 324 women, who were diagnosed with anal fissure, who applied to the General Surgery outpatient clinic between 2015 and 2020, were included in the study. The patients were divided into two groups; group I (medical treatment was successful) and group II (medical treatment failed - surgery performed). Both groups were compared in terms of age, body mass index (BMI), number of births, delivery type, birth weight, breastfeeding rate, constipation, diarrhea, smoking and anal fissure symptoms.

Results: Medical treatment was applied to all of the 324 patients we included in our study, and it was observed that 45.7% of them had successful medical treatment and 54.3% had undergone surgical treatment (lateral internal sphincterotomy) because of unsuccessful medical treatment. It was found that age, BMI, number of births, number of vaginal births, breastfeeding rate, constipation rates were higher in those who failed medical treatment (p 0.05). While gas incontinence was observed in 44.1% of those who underwent surgical treatment, this rate was found to be 1.4% in those who benefited from medical treatment.

Conclusion: In our study, it was found that while maternal age, number of births, vaginal delivery and breastfeeding rates had a negative effect on the success of anal fissure medical treatment, cesarean delivery and baby birth weight were not effective.
Research on the Professional Development Attitude of Minority English Teachers
Authors: Shi Hui
Published: June 2021

A total of 180 minority English teachers of different ages in middle schools are involved as quantitative research participants in this study. SPSS is applied to analyze the status quo and differences of their professional development attitude among different ages. The results show that they have the strong positive attitude toward their professional development, but teachers of different ages have significant differences in the dimensions of Professional Teaching Knowledge, Flexible Task Goals Consciousness as well as Rigid Task Target Consciousness.
The Senior High English Teaching Design Based on the Multiliteracies Pedagogy—From the Perspective of Cultivating Students’ Key Competency in English
Authors: Liu Xinzhu
Published: June 2021

Based on people-oriented moral education, the Key Competency of Chinese Students’ Development highlights the importance of cultivating students’ key competency, which means that students should have the essential character and core ability to adjust lifelong development and meet the demand of social development. According to the High School English Curriculum Standard (2017 Edition), key competency in English refers to language ability, thinking quality, cultural character and learning ability. And on the basis of multiliteracies pedagogy, linguistic symbols and non-linguistic symbols are combined together to create a multimodal teaching environment. And students will obtain new knowledge through four main stages: situated practice, overt instruction, critical framing and transferred practice, leading students mobilize their multiple senses together when learning English and help improve their comprehensive competence, which is in line with cultivating students’ key competency in English. This paper will firstly make a brief introduction of key competency in English based on the High School English Curriculum Standard (2017 Edition) and analyze typical views of multiliteracies pedagogy, then take the reading passage, Learning English from Unit5 Languages around the World, compulsory I, PEP as an example, applying multiliteracies pedagogy to English class, in order to cultivate students’ key competency in English to some extent through multiliteracy training.
Learning Strategies and English Language Teaching
Authors: Khansir Ali Akbar , Dehkordi Fatemeh Ghani , Mirzaei Mostafa
Published: June 2021

Learning strategy has been an important topic of English language among teachers, researchers and syllabus designers in the history of English language teaching. Learning strategy and English language occupy the central role in teaching and learning in EFL setting. This paper discusses learning strategies and English language teaching in English foreign language in Iran. The aim of this research paper was to report the results of learning strategies of a group of twenty Iranian students of English, doing their post-graduation. The subjects for this research paper were Persian –speaking students doing M.A. course in Persian Gulf University, Bushehr. In this research paper, two sets of questionnaires were conducted. The first set was a background questionnaire consisted of subjects, gender, age and language attitude etc. The other test was the original test of willing (1994) survey included learning strategies questionnaire. This test consisted of twenty nine –items. Results of the analysis of this paper revealed that leaning strategies is an important criterion in getting the English knowledge of EFL students in their class.
Preventive Psychological and Pedagogical Program “I Am a Fifth Grader”
Authors: Gobaeva I.R. , Gusova Z.K. , Soboleva O.O.
Published: June 2021

The program “I Am a Fifth Grader” is one of the main programs implemented today in the municipal autonomous institution of additional education the “Doverie” diagnostic and counseling center for children of Vladikavkaz aged 11–12 years. This program was developed and modified on the basis of the Methodological Recommendations for educational psychologists of educational organizations on conducting preventive work with minors experiencing difficulties in learning, upbringing and so-cialization. Has a preventive psychological and pedagogical orientation. The program is aimed at creating the necessary conditions for personal development, adaptation to constantly changing con-ditions, strengthening of psychological health, and the formation of 21st century skills in schoolchil-dren. The program “I Am a Fifth Grader” is implemented in accordance with the Strategy for the de-velopment of education in the Russian Federation for the period up to 2025, taking into account the mentality and region of the republic. The proposed program is based on the work of Russian psy-chologists dealing with the problems of interpersonal relations, adaptation of children of primary school age. The course of this program is built taking into account the individual, age, psychological and physiological characteristics of students and contributes to the achievement of educational goals through the mastery of universal educational actions by students. One of the leading tasks of psychological and pedagogical support is to create conditions for the free development of the per-sonality, expanding the educational space to provide children with the opportunity to gain a variety of social experiences, the formation of social skills necessary in a rapidly changing world, self-development and self-determination. This program involves a whole range of psycho-preventive measures, which are aimed not only at the individual psychological and pedagogical correction of the student's personality, but also at restoring his social status in the peer group.
In memoriam of our colleagues and friends
Authors: Gorbunova Victoria N.
Published: June 2021

The Department of General and Molecular Medical Genetics of St. Petersburg State Pediatric Medical University has existed for more than thirty years. Over these years, three outstanding scientists and clinical geneticists, our colleagues and members of the department, have passed away. Fundamental works of A.M. Polishchuk contributed to the study of radiation-induced chromosomal instability. One of the pioneers in the field of clinical cytogenetics in our country, A.M. Polishchuk was also at the origins of teaching genetics to future doctors. He was in the staff of the Department of Medical Genetics of St. Petersburg State Pediatric Medical University since its foundation in 1989, where his teaching experience was very appreciated. Having emigrated to Israel in the mid-1990s, A.M. Polishchuk continued his studies in laboratory genetics. The history of the development of genetics in Russia remained In the field of scientific interests of A.M. Polishchuk, until recent years. A.M. Polishchuk died in February 2020. Among the first members of the Department of Medical Genetics was also V.V. Krasilnikov. A student of the famous geneticist-neurologist E.A. Savelyeva-Vasilyeva, V.V. Krasilnikov became a prominent specialist in the field of clinical genetics, who spent more than three decades working at the Medical Genetic Center. An excellent diagnostician, he had a broad scientific outlook and deep knowledge in the study of microanomalies of development in hereditary pathology. After a long-lasting illness V.V. Krasilnikov died in 2012. V.G. Vakharlovsky was also a student of E.A. Savelyeva-Vasilyeva. The opus magnum of this outstanding clinician was the development of methods for pathogenetic therapy of the very grave hereditary diseases: WilsonKonovalov disease and spinal muscular atrophy. Having joined the team of the Department of Medical Genetics of the St. Petersburg State Pediatric Medical University in the 2000s, he brought into the educational process the practice of visiting a boarding home for mentally-handicapped children, introduced regular case studies. In 2010, with the Vakharlovskys death our collective suffered the big loss.
A Frequency-Domain-Based Algorithm for Detecting Microseismicity Using Dense Surface Seismic Arrays
Authors: Mesimeri Maria , Pankow Kristine L. , Rutledge James
Published: June 2021

We propose a new frequency-domain-based algorithm for detecting small-magnitude seismic events using dense surface seismic arrays. Our proposed method takes advantage of the high energy carried by S waves, and approximate known source locations, which are used to rotate the horizontal components to obtain the maximum amplitude. By surrounding the known source area with surface geophones, we achieve a favorable geometry for locating the detected seismic events with the backprojection method. To test our new detection method, we used a dense circular array, consisting of 151 5 Hz three-component geophones, over a 5 km aperture that was in operation at the Utah Frontier Observatory for Research in Geothermal Energy (FORGE) in southcentral Utah. We apply the new detection method during a small-scale test injection phase at FORGE, and during an aftershock sequence of an Mw 4.1 earthquake located ∼30  km north of the geophone array, within the Black Rock volcanic field. We are able to detect and locate microseismic events (Mw<0) during injections, despite the high level of anthropogenic activity, and several aftershocks that are missing from the regional catalog. By comparing our method with known algorithms that operate both in the time and frequency domain, we show that our proposed method performs better in the case of the FORGE injection monitoring, and equally well for the off-array aftershock sequence. Our new method has the potential to improve microseismic event detections even in extremely noisy environments, and the proposed location scheme serves as a direct discriminant between true and false detections.
Characteristics of Seismicity in the Eagle Ford Shale Play, Southern Texas, Constrained by Earthquake Relocation and Centroid Moment Tensor Inversion
Authors: Li Peng , Huang Guo-Chin D. , Savvaidis Alexandros , Kavoura Florentia , Porritt Robert W.
Published: June 2021

Analysis of earthquake locations and centroid moment tensors (CMTs) is critical in assessing seismogenic structures and connecting earthquakes to anthropogenic activities. The objective of this study was to gain insights into the seismotectonics of the Eagle Ford Shale play (EF), southern Texas, through relative relocation of earthquakes, assessment of CMT solutions, and investigation of the background stress field. Using Texas Seismological Network (TexNet) data from 2017 through 2019, we were able to relocate 326 earthquakes and obtain CMT solutions for 37 ML≥2.0 earthquakes. These earthquakes are located in the sedimentary basin and uppermost crust, with depths ranging from 2 to 10 km. The earthquake groups in the northeastern EF are linearly distributed along the Karnes fault zone, whereas the southern and western groups are spatially scattered around mapped or unmapped faults. CMT solutions identified 32 normal fault earthquakes and five strike-slip earthquakes. The orientation of the fault plane of most normal fault earthquakes is southwest–northeast, whereas the possible fault plane of the strike-slip fault is from north-northwest to south-southeast, which is roughly perpendicular to the normal faults. Normal and strike-slip faults in the EF are of high dip angles, with the dip angles of the most faults ranging from 60° to 80°. Stress inversion results show that the major orientation of maximum horizontal stress (SHmax) is southwest–northeast, with minor local stress-field rotations. We further estimated earthquake energy release in the EF region using moment magnitude from the CMT solutions, and the cumulative earthquake energy release curve reveals three notable increases in cumulative seismic moment, which occurred in January–July 2018 and January–March 2019, and May–August 2019. Whether these energy releases were caused by anthropogenic activities is a matter for further investigation.
Implementation of al-Ma’un Theology: The Movement of Muhammadiyah Educated Groups in Poverty Alleviation in Bulutellue Village, Sinjai Regency
Authors: Rahman Abdul , Syukur Muhammad , Jumadi Jumadi
Published: June 2021

In the concept of Islamic community development, welfare is an ideal condition for any social life. Efforts to create prosperity in Bulutellue Village also received attention from the Muhammadiyah education group. They invite the community, especially those from the rich to provide sustainable assistance to groups of the poor and orphans as a form of mainstreaming al-Ma’un theology. This study aims to describe the implementation of al-Ma’un theology in alleviating poverty in Bulutellue Village, Sinjai Regency. This study employed a qualitative method. The data were collected through observation and interviews. The results indicate that al-Ma’un theology was introduced by the educated group of Muhammadiyah Higher Education to the community of Bulutellue Village. This doctrine is accepted and implemented by the community in this village even though they are not registered as official members of the Muhammadiyah organization as an effort to make their income a way of gaining happiness and getting blessings from Allah SWT towards mutual benefit.
Impact of Banking Risks on the Electronic Banking Services: A Comparative Study
Authors: Jasim Mohammed Abdul-Hussein , Abdulkadhim Mohammed Munaf , Hussein Ahmed Ahmed
Published: June 2021

This paper aims to explore the impact of banking risk on electronic banking services in the Rafidain Bank and the Baghdad Bank. The study adopted the field survey method as a method of data collection and analysis. The sample included managers, their assistants, and the heads of departments who are at the decision-making site who were chosen intentionally, consisting of 43 people, including 25 from the Rafidain Bank and 18 from the Bank of Baghdad. A questionnaire was distributed to measure the study variables. The results show a significant impact of credit risk and liquidity risk on usability, benefits and cost reduction. Therefore, it is necessary to put in place mechanisms by the banks in question to help reduce risks, as these risks are the cause of many banking crises.
Sustainable Corporate Strategy: The Role of Human Capital in the Time of COVID-19 Crisis
Authors: Jílková Petra
Published: June 2021

The paper examines the role of human capital in sustainable corporate strategy, education and discusses the ways it supports corporate social responsibility (CSR). In order to identify how employee benefits and how education can support human capital development, quantitative research was realized via an online survey method through a structured questionnaire. Data were collected during two time intervals, before and during COVID-19 Crisis. We find evidence that employees have transformed their perceptions of employee benefits during the Crisis. The survey showed that with the majority of employees working from home due to the current situation, it is necessary to support more flexible working benefits as an integral part of creating a sustainable strategy. Moreover, the investment in employee education as the condition of sustainability is not supported by most of the investigated companies. Finally, the results indicate that the benefit structure is, for employees, an essential part of their job satisfaction and can support employees' loyalty to the firm.
Inhibition of Metabotropic Glutamate Receptor III facilitates sensitization to alkylating chemotherapeutics in Glioblastoma
Authors: Maier Julian , Ravi Vidhya , Kueckelhaus Jan , Behringer Simon , Garrelfs Niklas , Will Paulina , Sun Na , Ehr Jasmin , Goeldner Jonathan , Pfeifer Dietmar , Follo Marie , Hannibal Luciana , Walch Axel , Hofmann Ulrich , Beck Jürgen , Heiland Dieter Henrik , Schnell Oliver , Joseph Kevin
Published: June 2021

Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor treatment. Novel insights into the developmental trajectory exhibited by GBM show a strong capability to respond to its microenvironment by clonal selection of specific phenotypes. Using the same mechanisms, malignant GBM do develop intrinsic mechanisms to resist chemotherapeutic treatments. This resistance was reported to be sustained by the paracrine and autocrine glutamate signaling via ionotropic and metabotropic receptors. However, the extent to which glutamatergic signaling modulates the chemoresistance and transcriptional profile of the GBM remains unexplored. In this study we aimed to map the manifold effects of glutamate signaling in GBM as the basis to further discover the regulatory role and interactions of specific receptors, within the GBM microenvironment. Our work provides insights into glutamate release dynamics, representing its importance for GBM growth, viability, and migration. Based on newly published multi-omic datasets, we explored the and characterized the functions of different ionotropic and metabotropic glutamate receptors, of which the metabotropic receptor 3 (GRM3) is highlighted through its modulatory role in maintaining the ability of GBM cells to evade standard alkylating chemotherapeutics. We addressed the clinical relevance of GRM3 receptor expression in GBM and provide a proof of concept where we manipulate intrinsic mechanisms of chemoresistance, driving GBM towards chemo-sensitization through GRM3 receptor inhibition. Finally, we validated our findings in our novel human organotypic section-based tumor model, where GBM growth and proliferation was significantly reduced when GRM3 inhibition was combined with temozolomide application. Our findings present a new picture of how glutamate signaling via mGluR3 interacts with the phenotypical GBM transcriptional programs in light of recently published GBM cell-state discoveries.
Scientific Workflow Makespan Minimization In Edge Multiple Service Providers Environment
Authors: Bukhari S. Sabahat H. , Younus Muhammad Usman , Jaffari Zain-ul-Abidin , Hassan Muhammad Arshad Shehzad , Anjum Muhammad Rizwan , Narejo Sanam
Published: June 2021

The edge computing model offers an ultimate platform to support scientific and real-time workflow-based applications over the edge of the network. However, scientific workflow scheduling and execution still facing challenges such as response time management and latency time. This leads to deal with the acquisition delay of servers, deployed at the edge of a network and reduces the overall completion time of workflow. Previous studies show that existing scheduling methods consider the static performance of the server and ignore the impact of resource acquisition delay when scheduling workflow tasks. Our proposed method presented a meta-heuristic algorithm to schedule the scientific workflow and minimize the overall completion time by properly managing the acquisition and transmission delays. We carry out extensive experiments and evaluations based on commercial clouds and various scientific workflow templates. The proposed method has approximately 7.7% better performance than the baseline algorithms, particularly in overall deadline constraint that gives a success rate.
DESNN Algorithm For Communication Network Intrusion Detection
Authors: Liu Fulai , Xu Jialiang , Zhang Lijie , Du Ruiyan , Su Zhibo , Zhang Aiyi , Hu Zhongyi
Published: June 2021

Intrusion detection is a crucial technology in the communication network security field. In this paper, a dynamic evolutionary sparse neural network (DESNN) is proposed for intrusion detection, named as DESNN algorithm. Firstly, an ensemble neural network model is constructed, which is processed by a dynamic pruning rule and further divided into advantage subnetworks and disadvantage subnetworks. The dynamic pruning rule can effectively reduce the subnetworks weight parameters, thereby increasing the speed of the subnetworks intrusion detection. Then considering the subnetworks performance loss caused by the dynamic pruning rule, a novel evolutionary mechanism is proposed to optimize the training process of the disadvantage subnetworks. The weight of the disadvantage subnetworks approach the weight of the advantage subnetworks by the evolutionary mechanism, such that the performance of the ensemble neural network can be improved. Finally, an optimal subnetwork is selected from the ensemble neural network, which is used to detect multiple types of intrusion. Experiments show that the proposed DESNN algorithm improves intrusion detection speed without causing significant performance loss compare with other fully-connected neural network models.
Utility of quantitative antigen assay for SARS-CoV-2 in the clinical situation Single center experience from Japan
Authors: Nagasawa Masayuki , Inayoshi Reiko , Yamaguchi Yoshimi , Furuya Maki , Dohi Minoru , Ueda Ken , Harada Naoshige , Taki Reiko , Kurosaki Masayuki
Published: June 2021

From December 26, 2020 to February 28, 2021, quantitative antigen test (Ag test) of SARS-CoV-2 was conducted by using a nasopharyngeal swab for 990 patients aged from 0 to 99 years old (average age; 63.1 +/-22.5 years old, male: 537, female: 463), who presented at least one of the following symptoms, such as fever, respiratory symptoms, and taste disorder. In 578 patients, Ag test and PCR test were conducted at the same time and these patients were analyzed. In 74 patients with Ag > = 1.0, 44 patients were PCR positive (positive ratio = 0.59). In 43 patients with Ag > = 10.0, 41 patients were PCR positive (positive ratio = 0.95), and all of 42 patients with Ag > = 100.0 were PCR positive. In 504 patients with Ag < 1.0, only five patients were PCR positive (positive ratio = 0.01). In 31 patients with 10 > Ag > = 1.0, three patients were PCR positive (positive ratio = 0.10). All eight patients presented a typical pneumonia, and five patients had a history of close contact with COVID-19 patients within 14 days. With an appropriate cut off value, Ag test is concluded to have enough sensitivity and specificity. Considering the advantage of handiness, rapidness, high-throughput and economy over PCR test, Ag test seems useful diagnostic method for COVID-19 in the pandemic situation.
Protocol Refinement for a Diabetes Pragmatic Trial using the PRECIS-2 Framework
Authors: Glasgow Russell E. , Gurfinkel Dennis , Waxmonsky Jeanette , Rementer Jenny , Ritchie Natalie D. , Dailey-Vail Jennifer , Hosokawa Patrick , Dickinson L. Miriam , Kwan Bethany M.
Published: June 2021

Background: This report describes how we refined a protocol for a pragmatic comparative effectiveness study of two models of an evidence-based diabetes shared medical appointment intervention. Methods: We report primary data collected between June and August 2019, and protocol refinements completed between 2018 and 2020. Twenty-two members of the study team collaborated in protocol refinement and completed the PRECIS-2 ratings of study pragmatism. We discuss study design and refinements to achieve the desired level of pragmatism vs. experimental control for each of the nine PRECIS-2 dimensions. Study team members received training on PRECIS-2 scoring and were asked to rate the study protocol on the nine PRECIS-2 dimensions. Ratings are compared using descriptive statistics.Results: In general, the PRECIS-2 ratings revealed high levels of pragmatism, but somewhat less pragmatic ratings on the categories of Delivery and Organization (costs and resources). This variation was purposeful, and we provide the rationale for and steps taken to obtain the targeted level of pragmatism on each PRECIS-2 dimension, as well as detail design changes made to enhance pragmatism and address COVID-19 issues. There was general agreement among team members and across different types of stakeholders on PRECIS-2 ratings.Conclusions: We discuss lessons learned from use of PRECIS-2 and challenges in refining the study to be maximally pragmatic on some dimensions, yet well controlled on other dimensions. This paper expands on prior research by describing experimental design efforts to achieve targeted levels of pragmatism and describes our refinements for protocol fit to context. We make recommendations for future use of PRECIS-2 to help address changing context and other strategies for the planning of and transparent reporting on pragmatic research and comparative effectiveness research.Clinicaltrials.gov Registration ID: NCT03590041
Efficient Microstrip Antenna system using Reduced GP Structure for Ultra-Wide Band (UWB) Applications
Authors: N Parthiban , M Mohamed Ismail
Published: June 2021

Microstrip antenna is an essential choice for Ultra Wide Band (UWB) applications of its light weight, low profile and easy to form antenna arrays. However, the design of microstrip patch antenna bandwidth is greatly affects by the dielectric substrate material (FR4). In this research, the bandwidth enhancement of MPA was designed by minimizing the dimension of Defected GP (DGP) in GP for Ultra Wide Band wireless applications. But, the antenna design complexity increases with the number of an operating frequency band. In this research, the MPA was designed as small as size of 10×13×1.6 mm and operates on frequency band between 3.1GHz to 10.6GHz for VSWR less than 2. The microstrip patch antenna was designed at 3.1GHz to 10.6GHz using High-Frequency Structure Simulator (HFSS) software. The simulation result shows that the proposed microstrip patch antenna obtained <-10dB of return loss from 3.1GHz to 10.6GHz throughout the frequency range. The measured result proves that the proposed microstrip patch antenna has better characteristics to fulfill the requirements of UWB applications.
Oral Vitamin D3 Supplementation for Femtosecond LASIK–Associated Dry Eye
Authors: Lin Ying , Su Huanjun , Wu Jianbin , Yuan Muzhi , Zhang Yong
Published: June 2021

Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).