bluuebunny/crossref_metadata_2025 huggingface dataset:
Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?
Authors: Hart David A.
Published: October 2015

Inflammatory diseases and conditions can arise due to responses to a variety of external and internal stimuli. They can occur acutely in response to some stimuli and then become chronic leading to tissue damage and loss of function. While a number of cell types can be involved, mast cells are often present and can be involved in the acute and chronic processes. Recent studies in porcine and rabbit models have supported the concept of a central role for mast cells in a “nerve-mast cell-myofibroblast axis” in some inflammatory processes leading to fibrogenic outcomes. The current review is focused on the potential of extending aspects of this paradigm into treatments for multiple sclerosis and endometriosis, diseases not usually thought of as having common features, but both are reported to have activation of mast cells involved in their respective disease processes. Based on the discussion, it is proposed that targeting mast cells in these diseases, particularly the early phases, may be a fruitful avenue to control the recurring inflammatory exacerbations of the conditions.
Boerhaave Syndrome, Pneumothorax, and Chylothorax in a Critically Ill Patient with Tuberous Sclerosis Complex
Authors: Ijaz Mohsin , Rafiq Arsalan , Venkatram Sindhaghatta , Diaz-Fuentes Gilda
Published: October 2015

Tuberous sclerosis complex (TSC) is an autosomal dominant, variably expressed multisystem disease. The predominant pulmonary features of TSC are identical to those of lymphangioleiomyomatosis (LAM). Pneumothorax, multifocal micronodular pneumocyte hyperplasia, and chylothorax are rare complications of TSC. We report a young male with pneumothorax, lung nodules, and chylous effusion who developed empyema thoracis after esophageal rupture. Hospital course was complicated by respiratory failure. Family opted to transfer to hospice care. Chylothorax is a rare complication of TSC with few scattered reports mostly in female patients. Patients with TSC are usually managed by multispecialists and it is important to be aware of the rare pulmonary manifestations of this disease. A male patient with TSC having lung nodules presenting with chylothorax and empyema thoracis from Boerhaave syndrome makes our case unique.
Interleukin‐1 Family Cytokines in Liver Diseases
Authors: Tsutsui Hiroko , Cai Xianbin , Hayashi Shuhei
Published: October 2015

The gene encoding IL‐1 was sequenced more than 30 years ago, and many related cytokines, such as IL‐18, IL‐33, IL‐36, IL‐37, IL‐38, IL‐1 receptor antagonist (IL‐1Ra), and IL‐36Ra, have since been identified. IL‐1 is a potent proinflammatory cytokine and is involved in various inflammatory diseases. Other IL‐1 family ligands are critical for the development of diverse diseases, including inflammatory and allergic diseases. Only IL‐1Ra possesses the leader peptide required for secretion from cells, and many ligands require posttranslational processing for activation. Some require inflammasome‐mediated processing for activation and release, whereas others serve as alarmins and are released following cell membrane rupture, for example, by pyroptosis or necroptosis. Thus, each ligand has the proper molecular process to exert its own biological functions. In this review, we will give a brief introduction to the IL‐1 family cytokines and discuss their pivotal roles in the development of various liver diseases in association with immune responses. For example, an excess of IL‐33 causes liver fibrosis in mice via activation and expansion of group 2 innate lymphoid cells to produce type 2 cytokines, resulting in cell conversion into pro‐fibrotic M2 macrophages. Finally, we will discuss the importance of IL‐1 family cytokine‐mediated molecular and cellular networks in the development of acute and chronic liver diseases.
The Existence of Meromorphic Solutions of Some Types of Systems of Complex Functional Equations
Authors: Xu Hong-Yan , Wang Jin-Lian , Wang Hua
Published: October 2015

We investigate the existence of transcendental meromorphic solutions of some types of systems of complex functional equations and obtain some results about the existence of meromorphic solutions of such systems. Our results are improvement of the previous theorems given by Gao, Xu, and Zheng, and our examples show that our results are sharp to some extent.
Unilateral Acute Anterior Ischemic Optic Neuropathy in a Patient with an Already Established Diagnosis of Bilateral Optic Disc Drusen
Authors: Ayhan Ziya , Yaman Aylin , Söylev Bajin Meltem , Saatci A. Osman
Published: October 2015

Optic disc drusen (ODD) are calcific deposits that form in the optic nerve head secondary to abnormalities in axonal metabolism and degeneration. Anterior ischemic optic neuropathy, central retinal artery, and vein occlusion are among the rare vascular complications of disc drusen. We reported the clinical course of a 51-year-old patient with a unilateral acute nonarteritic anterior ischemic optic neuropathy (NAION) who received the diagnosis of bilateral optic disc drusen five years earlier and thereby reiterated the association of ODD and acute NAION.
Exponential Stabilization of a Class of Time-Varying Delay Systems with Nonlinear Perturbations
Authors: Tian Yazhou , Cai Yuanli , Sun Yuangong , Li Tongxing
Published: October 2015

This paper addresses the problem of exponential stabilization of a class of time-varying delay systems with nonlinear perturbations. These perturbations are related not only with current statextand the delayed statext−htbut also withβt, whereβtis a continuous function defined on[0,+∞). With the delay interval divided into two equidistant subintervals, a novel Lyapunov functional is introduced, and several new exponential stabilization criteria are derived in terms of linear matrix inequalities (LMIs) by employing reciprocally convex approach. Two examples are given to illustrate the effectiveness of the main results.
Mucoepidermoid Carcinoma of the Palatine Tonsil
Authors: Teixeira Lucas Novaes , Montalli Victor Angelo Martins , Teixeira Luiz Carlos Santana , Passador-Santos Fabrício , Soares Andresa Borges , Araújo Vera Cavalcanti de
Published: October 2015

Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy in both adults and children. It has a slight female predilection and usually presents as a painless, rubber-like or soft mass, which may be fixed or mobile. Histologically, MEC is comprised of a mixture of cell types including mucous, epidermoid, and intermediate cells that can be arranged in solid nests or cystic structures. In the oral cavity, it most frequently occurs at the palate or buccal mucosa. The present paper aimed to describe an unusual case of MEC arising in the palatine tonsil.
An Unusual Association: Iliopsoas Bursitis Related to Calcium Pyrophosphate Crystal Arthritis
Authors: Di Carlo Marco , Draghessi Antonella , Carotti Marina , Salaffi Fausto
Published: October 2015

A 71-year-old man with osteoarthritis and chondrocalcinosis came to our observation developing a swelling in the groin region after a recent left colectomy for adenocarcinoma. The imaging techniques revealed the presence of an iliopsoas bursitis in connection with the hip. The synovial fluid analysis detected the presence of calcium pyrophosphate (CPP) crystals and allowed the final and unusual diagnosis of iliopsoas bursitis related to acute CPP crystal hip arthritis.
Expansion Cohorts in First-in-Human Solid Tumor Oncology Trials
Authors: Theoret Marc R. , Pai-Scherf Lee H. , Chuk Meredith K. , Prowell Tatiana M. , Balasubramaniam Sanjeeve , Kim Tamy , Kim Geoffrey , Kluetz Paul G. , Keegan Patricia , Pazdur Richard
Published: October 2015

In 1962, the passage of the Kefauver–Harris Amendment to the 1938 Food, Drug, and Cosmetic Act required that sponsors seeking approval of new drugs demonstrate the drug's efficacy, in addition to its safety, through a formal process that includes “adequate and well-controlled” clinical trials as the basis to support claims of effectiveness. As a result of this amendment, FDA formalized in regulation the definitions of various phases of clinical investigations (i.e., phase I, phase II, and phase III). The clinical drug development paradigm for anticancer drugs intended to support marketing approval has historically followed this “phased” approach with sequential, stand-alone trials, with an increasing number of patients exposed to an investigational drug with each trial in order to fulfill the objectives of that particular stage in development. Increasingly, it is the Office of Hematology and Oncology Products' experience that commercial sponsors of solid tumor oncology drug development programs are amending ongoing phase I trials to add expansion cohorts designed to evaluate study objectives typical of later-phase trials. For investigational anticancer drugs that demonstrate preliminary clinical evidence of substantial antitumor activity early in clinical testing, use of expansion cohorts as a component of the solid tumor oncology drug development pathway, with appropriate measures to mitigate the risks of this approach, may fit in well with the goals and concepts described by FDA's expedited programs for serious conditions.Clin Cancer Res; 21(20); 4545–51. ©2015 AACR.

See all articles in this CCR Focus section, “Innovations to Speed Drug Development.”
The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases
Authors: Stewart David J. , Batist Gerald , Kantarjian Hagop M. , Bradford John-Peter , Schiller Joan H. , Kurzrock Razelle
Published: October 2015

High costs of complying with drug development regulations slow progress and contribute to high drug prices and, hence, mounting health care costs. If it is exorbitantly expensive to bring new therapies to approval, fewer agents can be developed with available resources, impeding the emergence of urgently needed treatments and escalating prices by limiting competition. Excessive regulation produces numerous speed bumps on the road to drug authorization. Although an explosion of knowledge could fuel rapid advances, progress has been slowed worldwide by inefficient regulatory and clinical research systems that limit access to therapies that prolong life and relieve suffering. We must replace current compliance-centered regulation (appropriate for nonlethal diseases like acne) with “progress-centered regulation” in lethal diseases, where the overarching objective must be rapid, inexpensive development of effective new therapies. We need to (i) reduce expensive, time-consuming preclinical toxicology and pharmacology assessments, which add little value; (ii) revamp the clinical trial approval process to make it fast and efficient; (iii) permit immediate multiple-site trial activation when an eligible patient is identified (“just-in-time” activation); (iv) reduce the requirement for excessive, low-value documentation; (v) replace this excessive documentation with sensible postmarketing surveillance; (vi) develop pragmatic investigator accreditation; (vii) where it is to the benefit of the patient, permit investigators latitude in deviating from protocols, without requiring approved amendments; (viii) confirm the value of predictive biomarkers before requiring the high costs of IDE/CLIA compliance; and (ix) approve agents based on high phase I–II response rates in defined subpopulations, rather than mandating expensive, time-consuming phase III trials. Clin Cancer Res; 21(20); 4561–8. ©2015 AACR.

See all articles in this CCR Focus section, “Innovations to Speed Drug Development.”
Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Authors: Hingorani Pooja , Missiaglia Edoardo , Shipley Janet , Anderson James R. , Triche Timothy J. , Delorenzi Mauro , Gastier-Foster Julie , Wing Michele , Hawkins Douglas S. , Skapek Stephen X.
Published: October 2015

Purpose: Pediatric rhabdomyosarcoma (RMS) has two common histologic subtypes: embryonal (ERMS) and alveolar (ARMS). PAX–FOXO1 fusion gene status is a more reliable prognostic marker than alveolar histology, whereas fusion gene–negative (FN) ARMS patients are clinically similar to ERMS patients. A five-gene expression signature (MG5) previously identified two diverse risk groups within the fusion gene–negative RMS (FN-RMS) patients, but this has not been independently validated. The goal of this study was to test whether expression of the MG5 metagene, measured using a technical platform that can be applied to routine pathology material, would correlate with outcome in a new cohort of patients with FN-RMS.

Experimental Design: Cases were taken from the Children's Oncology Group (COG) D9803 study of children with intermediate-risk RMS, and gene expression profiling for the MG5 genes was performed using the nCounter assay. The MG5 score was correlated with clinical and pathologic characteristics as well as overall and event-free survival.

Results: MG5 standardized score showed no significant association with any of the available clinicopathologic variables. The MG5 signature score showed a significant correlation with overall (N = 57; HR, 7.3; 95% CI, 1.9–27.0; P = 0.003) and failure-free survival (N = 57; HR, 6.1; 95% CI, 1.9–19.7; P = 0.002).

Conclusions: This represents the first, validated molecular prognostic signature for children with FN-RMS who otherwise have intermediate-risk disease. The capacity to measure the expression of a small number of genes in routine pathology material and apply a simple mathematical formula to calculate the MG5 metagene score provides a clear path toward better risk stratification in future prospective clinical trials. Clin Cancer Res; 21(20); 4733–9. ©2015 AACR.
Advancing Clinical Trials to Streamline Drug Development
Authors: Bates Susan E. , Berry Donald A. , Balasubramaniam Sanjeeve , Bailey Stuart , LoRusso Patricia M. , Rubin Eric H.
Published: October 2015

The last decade in oncology has been marked by the identification of numerous new potential cancer targets and even more agents designed to inhibit them. The matrix of new targets, new agents, and the companion diagnostics required to identify the right patient for the right drug has created a major challenge for the clinical trial process. This has been compounded by the addition of new immunomodulators targeting the host immune system rather than the tumor. Recognizing the need for new approaches, industry, investigators, and regulators have responded to this challenge. New clinical trial designs are being evaluated to incorporate the genomic sequence data being obtained almost routinely after cancer diagnosis. New dose-finding approaches are being proposed to identify the maximum effective dose rather than the maximum tolerated dose. The FDA is involved in the drug approval process from points early in development and has accepted registration quality data from expansion cohorts in support of drug approval. Despite progress on several fronts, many challenges remain, including the lack of predictability of preclinical data for clinical results and phase II data for phase III results, an infrastructure that can be an obstacle to clinical trial development and implementation, and the increasing use of contracted clinical research organizations that limit a fit-for-purpose approach to clinical trial execution. Perhaps most challenging and important of all are the difficulties with clinical trial accrual that can prevent study completion. Both the innovations and the challenges highlight the important role of process in progress in clinical oncology. Clin Cancer Res; 21(20); 4527–35. ©2015 AACR.

See all articles in this CCR Focus section, “Innovations to Speed Drug Development.”
Novel Imaging Diagnosis for Hepatocellular Carcinoma: Consensus from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014)
Authors: Chen Bang-Bin , Murakami Takamichi , Shih Tiffany Ting-Fang , Sakamoto Michiie , Matsui Osamu , Choi Byung-Ihn , Kim Myeong-Jin , Lee Jeong Min , Yang Ren-jie , Zeng Meng-Su , Chen Ran-Chou , Liang Ja-Der
Published: October 2015

Current novel imaging techniques in the diagnosis of hepatocellular carcinoma (HCC), with the latest evidence in this field, was discussed at the Asia-Pacific Primary Liver Cancer Expert (APPLE) meeting held in Taipei, Taiwan, in July 2014. Based on their expertise in a specific area of research, the novel imaging group comprised 12 participants from Japan, South Korea, Taiwan, and China and it included 10 abdominal radiologists, one hepatologist, and one pathologist. The expert participants discussed topics related to HCC imaging that were divided into four categories: (i) detection method, (ii) diagnostic method, (iii) evaluation method, and (iv) functional method. Consensus was reached on 10 statements; specific comments on each statement were provided to explain the rationale for the voting results and to suggest future research directions.
Enhanced Neuroprotective Effects of Combination Therapy with Bone Marrow-Derived Mesenchymal Stem Cells and Ginkgo biloba Extract (EGb761) in a Rat Model of Experimental Autoimmune Encephalomyelitis
Authors: Hao Fei , Li Aiping , Yu Huan , Liu Meichen , Wang Yachen , Liu Jing , Liang Zhanhua
Published: October 2015

Objectives: We investigated whether Ginkgo biloba extract (EGb761) can provide neuroprotective effects and enhance the efficacy of bone marrow-derived mesenchymal stem cells (BMSCs) in a rat model of experimental autoimmune encephalomyelitis (EAE). Methods: We examined the synergistic action of BMSCs combined with EGb761 treatment in EAE rats. The immunized rats received an intravenous injection of BMSCs or intraperitoneal administration of EGb761 or both on the day of the onset of clinical symptoms and for the following 21 days. Clinical severity scores were recorded daily and histopathological examination of the spinal cord and cytokine concentrations in the serum were studied on days 14 and 31 postimmunization. Results: Our results showed that combined treatment with BMSCs and EGb761 further decreased the disease severity, maximal clinical score and number of infiltrated mononuclear cells, especially CD3-positive T cells. We observed that the demyelination score and the density of axonal loss in the spinal cord were significantly reduced in mice receiving the combination therapy. The serum concentrations of the phosphorylated neurofilament heavy chain, tumor necrosis factor-α and interferon-γ were reduced in the combination-treatment group. Conclusion: Our results suggest that combined treatment with BMSCs and EGb761 have a synergistic effect in rats with EAE by inhibiting the secretion of proinflammatory cytokines, demyelination and protecting axons and neurons.
PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency
Authors: Plu-Bureau Genevieve , Horellou Marie Héléne , Rauch Antoine , Suchon Pierre , Alhenc-Gelas Martine ,   for the GEHT genetic thrombophilia group
Published: October 2015

Inherited protein S deficiency (PSD) is an established risk factor for venous thromboembolism (VTE). However, data are conflicting concerning risk of VTE associated with decreased free PS level (FPS) and information on PROS1 genotype-phenotype relationship is sparse. In a retrospective cohort of 579 patients with inherited type I/III deficiency suspicion, PROS1 genotyping was performed and the effect of genotype on FPS and on VTE risk was investigated. We found 116 (including 65 novel) detrimental mutations (DM) in 222 (type I/III in 194, type II in 28), PS Heerlen in 74, possibly non DM in 38 and no mutation in 245 subjects. Among DMs, type I/IIIDMs only were found in subjects with FPS<30 %. Prevalence of type I/III DM decreased with increasing FPS level. Risk of VT associated with FPS level and genotype was studied in the 467 subjects with personal or family history of thrombosis. Only type I/IIIDM carriers presented with an increased risk of VTE [1.41 (95%CI (1.05–1.89)] compared to subjects with no mutation. Among the group of type I/IIIDM heterozygotes and subjects with no mutation, the optimal FPS cut-off point for identifying subjects at increased VTE risk was searched for. We found that only subjects with FPS<30% and type I/IIIDM presented with an increased risk [1.48 (95%CI 1.08–2.04)]. Our findings confirm the value of a cut-off FPS level for identifying subjects at increased VTE risk far below the lower limit of the normal range and suggest a place for PROS1 genotyping in PSD diagnosis strategy.
Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa
Authors: Gale Andrew J. , Griffin John H. , Mosnier Laurent O. , Bhat Vikas , Drygalski Annette von
Published: October 2015

Bypassing inhibitors in haemophilia patients is limited to activated (a) Factor(F)VII products. We introduced “FVa activity augmentation” as another bypassing strategy and studied effects of an engineered FVa variant designated superFVa. Procoagulant and clot stabilising properties of superFVa and recombinant human (rh)FVIIa, either alone or in combination, were studied in thrombin generation and clot lysis assays in normal human plasma (NHP) with or without anti-FVIII inhibitors, in haemophilia plasma, and in FVIII-deficient mice or in wild-type mice with anti-FVIII inhibitors. SuperFVa was as effective as rhFVIIa to improve thrombin generation or clot lysis. Furthermore, procoagulant effects were significantly enhanced when these compounds were combined. RhFVIIa at 40 nM (a therapeutic concentration) improved thrombin generation mildly, but markedly improved thrombin generation when combined with a low concentration (e. g. 3 nM) of superFVa. In clot lysis studies, the concentration of rhFVIIa to normalise clot lysis times could be reduced by 100-fold (e. g. from 40 nM to 0.4 nM) when combined with a low concentration (0.37 nM) of superFVa. In haemostasis studies of FVIII-deficient mice, blood loss was dose-dependently reduced by either superFVa or rhFVIIa. SuperFVa (200 U/kg) corrected mean blood loss indistinguishably from rhFVIII. Blood loss correction by rhFVIIa was greatly improved when combined with superFVa. Similar blood loss correction results were observed for therapies in wild-type mice after infusion with anti-FVIII inhibitors. Thus, superFVa may be an effective procoagulant agent in the setting of haemophilia with inhibitors and it merits further evaluation for new bypassing strategies.

Supplementary Material to this article is available online at www.thrombosis-online.com.
Dabigatran treatment simulation in patients undergoing maintenance haemodialysis
Authors: Kreuzer Joerg , Brueckmann Martina , Schulze Friedrich , Liesenfeld Karl-Heinz , Clemens Andreas
Published: October 2015

Patients with atrial fibrillation requiring maintenance haemodialysis are at increased risk of ischaemic stroke and bleeds. Currently, vitamin K antagonists such as warfarin are predominantly used in these patients as limited data are available on the use of non-vitamin K oral anticoagulants, including dabigatran etexilate (dabigatran). Dabigatran is approximately 85 % renally eliminated, thus, its half-life is prolonged in renal impairment. This study simulated the dose-exposure relationship of dabigatran in patients undergoing haemodialysis. Dabigatran exposure was modelled at once- and twice-daily doses of 75 mg, 110 mg and 150 mg and at variations in non-renal clearance and dialysis settings. Resultant dose exposure (area under the curve [AUC]) was compared with values simulated from typical patients in the RE-LY® trial (based on a previously characterised pharmacometric model). In this simulation, all twice-daily dosages resulted in exposures above those simulated from typical RE-LY patients (1.5- to 3.3-fold increase in AUC) and thus may not be optimal for use in haemodialysis patients. However, dabigatran doses of 75 mg or 110 mg once daily produced exposures comparable to those simulated in typical RE-LY patients (-13.3 and +4.4 %, respectively). Of patient and dialysis variables, non-renal clearance had the highest impact on exposure (≤30.8 % change). These data could potentially inform dose selection in patients undergoing maintenance haemodialysis and the findings warrant investigation in future clinical trials.
O espelho invertido
Authors: Giannotti Marco
Published: October 2015

O objetivo deste artigo é discutir de que modo a pintura dos imigrantes japoneses residentes no Brasil está de alguma maneira relacionada ao que o Japão produziu nos períodos moderno e contemporâneo. Ao longo de sua pesquisa, o autor constatava com espanto que a grande maioria dos japoneses não fazia ideia da importância cultural que possuem seus imigrantes para o contexto brasileiro. A conclusão primeira era a de que seria muito difícil estabelecer uma comparação direta entre os dois grupos sem levar em consideração um estilo internacional (americano e europeu), bem como a personalidade e o estilo dos artistas abordados.
Investigação e arte: enunciação e propósitos
Authors: Laranjo Francisco
Published: October 2015

Pretendemos refletir sobre o que se depara ao artista enquanto criador e investigador, ao mesmo tempo em que olhamos o universo da criação e investigação contemporâneas nas instituições universitárias e museológicas. Uma abordagem ao que se pode entender por criação e investigação legitimadas, é ainda alvo de atenção.
Obra expandida: as vanguardas e o regime alográfico
Authors: Freitas Artur
Published: October 2015

Este texto é um ensaio de interpretação a respeito do caráter “múltiplo” e “projetual” de determinadas obras de vanguarda a partir da “teoria dos regimes de imanência” de Nelson Goodman e Gérard Genette. Por hipótese, suporemos que a aceitação do chamado “regime alográfico” no âmbito das artes visuais tenha sido responsável, no contexto histórico das vanguardas, pelo surgimento de obras de arte “projetuais”.
O espaço entre – A fotografia de Majida Khattari
Authors: Tavares Mirian
Published: October 2015

A artista marroquina Majida Khattari utiliza a fotografia, as instalações e os desfiles de moda como uma provocação/reflexão sobre o papel do véu no universo muçulmano e no imaginário ocidental. Na série de fotografias denominada Orientalismes, a artista recria os quadros de Delacroix de uma forma subversiva. A relação com a obra do pintor ultrapassa a mera questão temática e pode ser aprofundada. Paul Jamot, ao falar da obra de Delacroix na Documents nº 5, de 1930, diz que qualquer tema, nas mãos do artista, converte-se numa forma de revelação e numa visão trágica, tanto nos gestos desesperados de homens em luta, como na aparente lassidão das jovens cativas. O uso das imagens orientalistas de Delacroix, por Majida Khattari, absorve o sentido trágico e absorve ainda a ideia da imagem como meio de eternizar e universalizar gestos quotidianos. Os véus que, na sua obra, escondem e desvelam, funcionam como mecanismos que tornam visível o que se quer ocultar. Este é o procedimento utilizado nos seus desfilesinstalações, que criam a delimitação de um espaço ambíguo entre eu e o outro. Entre o que se vê e o que se mostra.
Poéticas da memória: invenção e descoberta no uso de metadados para a criação de memórias culturais em ambientes programáveis
Authors: Falci Carlos Henrique
Published: October 2015

A memória precisa de um lugar fixo para se estabelecer? A memória precisa de arquivos para existir? E que tipo de arquivos? Embora se possa dizer que a memória talvez nunca tenha se definido a partir de um lugar fixo, penso que o próprio estabelecimento do conceito enquanto tal é marcado pela ideia de um lugar, de um registro em que a memória possa ser encontrada. Mesmo quando ela é associada ao imaginário, ou ao que é instável, há uma tensão associada à busca de um local da/para a memória. O propósito desse capítulo é discutir como o uso de metadados, de maneira poética, pode configurar outras lógicas para a criação de memórias culturais em ambientes programáveis. Lógicas que sugerem outros operadores conceituais para delimitar as memórias, que misturam lugares fixos com lugares em rede, invenção e descoberta, políticas e poéticas, memórias culturais e memórias comunicativas. Os metadados são pensados aqui como elementos capazes de operar as passagens indicadas. Para investigar a potência dos metadados, foi feita uma análise do projeto The Whale Hunt, buscando entender de que maneira essa narrativa se apropria dos metadados de maneira poética, criando lugares imaginários de memória.
Acheiropoiesis: sobrevivência do valor de culto na imagem técnica
Authors: Entler Ronaldo
Published: October 2015

Toda imagem sagrada possui uma profunda identificação com aquilo que representa. Conforme a tradição cristã, é pela acheiropoiesis que essa experiência é levada ao limite: trata-se do milagre pelo qual o ser divino deixa uma imagem de si mesmo, sem a ação da mão do homem. Muito distante desse contexto, algumas fotografias parecem ainda tocar o desejo de encontrar a imagem a manifestação espontânea de um objeto afetivo. Isso aponta para um paradoxo: a possibilidade de sobrevivência de um "valor de culto" nas mesmas imagens técnicas que pareciam superá-lo.
O mundo e os mundos da arte de Arthur C. Danto: uma teoria filosófica em dois tempos.
Authors: Silveira Cristiane
Published: October 2015

O artigo apresenta duas versões temporalmente afastadas da noção de "mundo da arte" formulados pelo filosófo Arthur C. Danto (1924-2013). A primeira apresentada no clássico artigo de 1964 "The artworld", em resposta a seu círculo filosófico mais próximo, e diante da aparente radicalidade dos exemplares exibidos como obras de arte naquele período; e a segunda, apresentada no ensaio "The art world revisited: comedies of similarities", de 1992, como uma tentativa cabal de afastar sua teoria da sombra da Teoria Institucional de George Dickie e da noção de mundo da arte ali implicada.
O lugar e as manchas do trabalho de João Loureiro
Authors: Riccioppo Carlos Eduardo
Published: October 2015

Este artigo discute um grupo de trabalhos de João Loureiro - as obras Passagem secreta, Piscina, Projeto para a ocupação de uma casa, desenhos do artista, Zootécnico e Blue Jeans -, marcado por uma conexão imediata com os lugares determinados em que foram realizados, buscando indagar em que medida a obra do artista depende das menores particullaridades envolvidas nas situações objetivas que propiciam seu aparecimento no espaço.
Relato de pesquisa: da similaridade na montagem à tela em movimento
Authors: Gerheim Fernando
Published: October 2015

A similaridade é uma força tão fundamental na linguagem que está presente mesmo na linguagem de imagens do cinema. É o que mostram sequências de Outubro (1929), de Eisenstein, apesar do cineasta declarar que seu princípio de montagem é o conflito. A videoinstalação CinemObjeto (2012), realizada como parte dessa pesquisa, investiga o uso da montagem para além da gramática interna do filme, considerando os elementos que circunscrevem o cinema, tanto material e tecnicamente quanto em termos de formas discursivas. A montagem aqui não é entre duas imagens, mas entre imagem e tela em movimento. Esse procedimento, através da "exterioridade da linguagem", produz "imagens emersivas". Estreitando relações entre teoria e prática, videoinstalação e filosofia, esta pesquisa em progresso explora potências da linguagem audiovisual.
A retórica procedimental como agente de articulação entre identidade e alteridade
Authors: Tavares Monica
Published: October 2015

O objetivo deste artigo é examinar como a retórica procedimental fundamenta processos dialéticos de corporificação-descorporificação, mantenedores das trocas sucessivas entre seft e other. Em primeiro lugar, exporemos a noção de retórica procedimental, entendida como técnica de argumentação e persuasão, estabelecida com base em sistemas computacionais. Em segundo lugar, analisaremos como a dialética entre corporificação e descorporificação firma-se como aspecto central de influência na construção do sentido de self e other. Em terceiro lugar, discutiremos como a noção de interface pode ser considerada como mapas procedimentais e computacionais que, sedutora e ideologicamente, induzem os comportamentos dos receptores. Por fim, apresentaremos a obra Alter Ego, de Alexa Wright & Alf Linney, como exemplo de trabalho que, de modo crítico e reflexivo, discute o que está na base das experiências de corporificação e descorporificação e como essas experiências potencializam trocas sucessivas entre identidade e alteridade.
On the wings of moths: José Oiticica Filho's science and photography
Authors: Valentin Andreas
Published: October 2015

From the second half of the 1940s and more so in the 1950s, Brazilian photography renewed itself, initially within the photoclub circuits, in particular the Foto Cine Clube Bandeirantes in São Paulo, and later in the context of Brazilian constructivist movements. In this scenario, stands out the work of entomologist and photographer José Oiticica Filho (1906-1964). Analyzed here is his photographic production, its close relationship to his scientific research and methods as well as his encounter with the Brazilian Concrete and Neoconcrete Movements. Addressed also is the proximity of his work to the post-second World War German photography, particularly the fotoform and subjektive fotografie groups.
Colonized image
Authors: Linares Claudia Rodríguez-Ponga
Published: October 2015

This essay looks into the magical origin of the term imago and its problematic relation to the real and illusory within a binary and morally connoted logic. Based on Durand’s image theory and benefiting from an analogy between Hal Foster’s Return of the real an Euripides’ Bacchae, a deeply rooted cultural fear of the image as other and schizophrenic denial of its power are revealed. An analysis of perspective as a legitimating tool follows, drawing directly from Hans Belting’s Florence and Baghdad, in which the origin of this typically western stance is traced back to the medieval Arab science. The distorted theory which the Italian renaissance championed had unforeseen consequences on western thought and lead to visuality as Nicholas Mirzoeff defines it in “The right to look”.
Art and interaction: language and production of meaning
Authors: Fogliano Fernando
Published: October 2015

This study seeks to deepen the understanding of the interactive processes in the field of technological art. For it will fetch in the studies of George Lakoff and Mark Johnson the elements needed to produce a perspective able to offer a deeper understanding of the processes involved in the production of meanings and aesthetic experience.
Design and Comparison of Immersive Interactive Learning and Instructional Techniques for 3D Virtual Laboratories
Authors: Ren Shuo , McKenzie Frederic D. , Chaturvedi Sushil K. , Prabhakaran Ramamurthy , Yoon Jaewan , Katsioloudis Petros J. , Garcia Hector
Published: October 2015

This work presents the design, development, and testing of 3D virtual laboratories for practice, specifically in undergraduate mechanical engineering laboratories. The 3D virtual laboratories, implemented under two virtual environments—3DTV and Computer Automated Virtual Environment (CAVE)—serve as pre-lab sessions performed before the actual physical laboratory experiment. The current study compares the influence of two instructional methods (conventional lecture-based and inquiry-based) under two virtual environments, and the results are compared with the pre-lab sessions using a traditional paper-based lab manual. Subsequently, the evaluation is done by conducting performance and quantitative assessments from students' pre- and post-laboratory performances. The research results demonstrate that students in the virtual modules (3DTV and CAVE) performed significantly better in the actual physical experiment than the students in the control group in terms of the overall experiment familiarity and procedure and the conceptual knowledge associated with the experiment.
Ritual Slaughter, Animal Welfare and the Freedom of Religion
Authors: Vellenga Sipco
Published: October 2015

In 2011, the Dutch House of Representatives voted for the first time in its history for banning the practice of unstunned ritual slaughter in accordance to Jewish and Islamic rites. How should this remarkable vote be understood? In order to answer this question, a critical discourse analysis has been carried out. Three discourses are discerned in the debate: ‘unstunned ritual slaughter as an outdated practice,’ ‘ritual slaughter as a form of ritual torture’ and ‘unstunned ritual slaughter as a legitimate religious practice.’ The growing parliamentary support for the first two mentioned discourses is related to recent changes in the Dutch political landscape. In a wider context, it is related to a shift in the national self-conception of the Netherlands and, linked to that, to a change in the perceived position of traditional religious minorities within Dutch society in the aftermath of 9/11 and the ‘Fortuyn revolt.’
Uneasy Allies
Authors: Boczar Amanda
Published: October 2015

Relations between u.s. servicemen and Vietnamese civilians represent one of the most persistent cultural legacies of the Vietnam War. From brides to bar girls to crass film tropes of Vietnamese sex workers, women occupy a prominent place in the war’s memory. At the time, however, the media and u.s. government officials portrayed sex as a subtext to the larger conflict. From the outset, officials on all sides of the negotiating table struggled over how to contain the diverse impacts of the relationships on health, security, and morale. Prostitution played a central role in the debate. u.s. officials attempted to discount the significance of their impact on foreign relations and warfare, but social relationships indeed had an impact on how Americans engaged Saigon’s leaders. While scholars typically have shown the United States as the dominant power in Vietnam, sexuality became a somewhat level playing field where both governments feared the repercussions of limiting intercultural intimacy as much as they feared letting it continue. At first, the Saigon government enacted strict laws and attempted to prosecute violators, but never committed to eradication. By the war’s height u.s. officials adopted rigorous new programs which led to an Americanization of sexual and social policies regarding prostitution in Vietnam.
The Playboy Way
Authors: Batura Amber
Published: October 2015

Scholars often have ignored Playboy magazine’s role in the Vietnam War because many have assumed its only function was to provide soldiers with erotic images of women. This article analyzes Playboy’s content to explain its popularity in the Vietnam War. While acknowledging the importance of erotic images, this examination explores alternative reasons soldiers and the military embraced this “girlie mag.” Centerfolds provided soldiers with “round-eyed” sexuality, but the magazine also fulfilled other needs of the soldiers. Playboy provided a conduit through which soldiers understood social, cultural, and political issues of the time. Playboy’s treatment of racial tension, military life, the politics of the Vietnam War, and the individual soldier combined with the girl-next-door sexuality that appealed to soldiers on multiple levels made Playboy the magazine of the Vietnam War. Considering what surrounds the centerfold in Playboy illustrates the surprising importance of Playboy to soldiers and the military.
Paepalanthus echinoides (Eriocaulaceae), a new species from central Brazil with notes on leaf and scape anatomy
Authors: Trovó Marcelo , Silva Arthur , Coan Alessandra Ike
Published: October 2015

Paepalanthus echinoides, a new species of Paepalanthus sect. Conodiscus, is described and illustrated. This new species is endemic to central Brazil, growing in sandy and humid soils. It is easily distinguished by its dimerous flowers, small leaves arranged in a rosette, the capillaceous and numerous scapes, the small capitula, and the adpressed, dark brown spathes. We present comparisons with P. sphaerocephalus and P. exiguus, the other two species of P. sect. Conodiscus. We also provide a distribution map and photographs, as well as comments on morphological variation, anatomy of leaves and scapes, habitat, phenology, and conservation status.
Three new species of tiger beetles and new data on Cicindelina species from Angola (Coleoptera: Carabidae: Cicindelinae)
Authors: Serrano Artur R.M. , Capela Rúben A. , OESTERLE ANDREAS
Published: October 2015

Three new species of tiger beetles, two of the genus Trichotaenia Rivalier, 1957 and one of the genus Cylindera Westwood, 1831, subgenus Ifasina Jeannel, 1946 are described from Angola. An annotated list of species of Cicindelina sampled in this country is provided also. Records for three species previously unknow from Angola are given: Ophryodera smrzi Werner, 2005, Lophyra clatharta (Dejean, 1825) and Lophyra sumlini Cassola, 1976. Some considerations on the distribution and general ecology of these beetles in Angola are also presented. Further, two dichotomic keys are made available for the identification of Trichotaenia species with marked shoulders and Cylindera (Ifasina) species of western and southwestern Africa, respectively.
Ischnura foylei sp. nov. (Odonata, Coenagrionidae) from the highlands of Sumatra
Authors: KOSTERIN OLEG E.
Published: October 2015

Ischnura foylei sp. nov. is described from Indonesia, Sumatra, Jambi Province, Danau Gunung Tujuh (or Danau Sakti), a lake situated in an extinct volcanic crater, 1°41'15"S, 101°25'28"S, 1995 m a.s.l. Structurally it is close to I. senegalensis but larger and with differently shaped cerci in males and a more trilobate posterior lobe of the prothorax; males and androchromatic females have a unique colour pattern.
A new species of Charinus Simon, 1892 (Amblypygi, Charinidae) from termite nests in French Guiana
Authors: RÉVEILLION F. , MAQUART P.O.
Published: October 2015

The genus Charinus is represented by 51 species, distributed in all tropical regions. Their small size allows them to use a wide range of micro-habitats, from caves, litter to insect nests. The new species C. sillami sp. nov. was found into termite nests of three different species: Neocapritermes taracua, Spinitermes sp. and Embiratermes neotenicus. Only Paracharon caecus (Paleoamblypygi: Paracharontidae) was previously known to be associated with Isoptera. Eleven species of Charinus were previously known from Northern South America. Charinus sillami sp. nov. is the second species of the genus occurring in French Guiana. An updated key of Northern South-American species is provided.
Redescription of males of the aphid species Cinara (Cupressobium) tujafilina and Cinara (Cupressobium) cupressi (Hemiptera, Lachninae)
Authors: DURAK ROMA , DURAK TOMASZ
Published: October 2015

This paper presents the first comprehensive description of the winged males of Cinara tujafilina and Cinara cupressi (Hemiptera, Lachninae) and establishes the morphological characters enabling differentiation between them. We show that some populations of C. tujafilina, a species considered to be anholocyclic, may not have lost the genetic ability to produce males and under favourable conditions can develop in a holocyclic manner.
New species and subspecies of the genus Lesteva Latreille, 1797 (Coleoptera: Staphylinidae: Omaliinae) from Taiwan
Authors: SHAVRIN ALEXEY V.
Published: October 2015

Two new taxa of the genus Lesteva Latreille, 1797 from Taiwan (Hualien County) are described and illustrated: L. smetanai sp. n. and L. rufopunctata taiwanica subsp. n. A key to species known from Taiwan is provided.
Paraclausastrea vorarlbergensis sp. nov.; a new coral from the Lower Cretaceous of western Austria (Scleractinia; upper Barremian-lower Aptian; Schrattenkalk Fm.; Vorarlberg)
Authors: BARON-SZABO ROSEMARIE C.
Published: October 2015

The new taxon Paraclausastrea vorarlbergensis sp. nov. is described from the upper Barremian-lower Aptian (Schrattenkalk Fm.) of western Austria (Vorarlberg). It belongs to the montlivaltiids and is characterized by thamnasterioid to submeandroid corallite integration, diameters of corallites ranging between 3 and 6.5 mm, and septa that are generally developed in 4 incomplete cycles in 6 generally irregular systems. In a small number corallites that are around 6 mm in diameter, 4 complete cycles are present. In corallites that are around 2 mm in diameter, usually between 12 and 18 septa are present. The new species differs from all other forms of Paraclausastrea in having the largest number of septa. This is the first report of this genus for the Schrattenkalk Formation.
Projection of Climate Change Influences on U.S. West Nile Virus Vectors
Authors: Brown Heidi E. , Young Alex , Lega Joceline , Andreadis Theodore G. , Schurich Jessica , Comrie Andrew
Published: October 2015

While estimates of the impact of climate change on health are necessary for health care planners and climate change policy makers, models to produce quantitative estimates remain scarce. This study describes a freely available dynamic simulation model parameterized for three West Nile virus vectors, which provides an effective tool for studying vectorborne disease risk due to climate change. The Dynamic Mosquito Simulation Model is parameterized with species-specific temperature-dependent development and mortality rates. Using downscaled daily weather data, this study estimates mosquito population dynamics under current and projected future climate scenarios for multiple locations across the country. Trends in mosquito abundance were variable by location; however, an extension of the vector activity periods, and by extension disease risk, was almost uniformly observed. Importantly, midsummer decreases in abundance may be offset by shorter extrinsic incubation periods, resulting in a greater proportion of infective mosquitoes. Quantitative descriptions of the effect of temperature on the virus and mosquito are critical to developing models of future disease risk.
Not All Generic Concerta Is Created Equal
Authors: Lally Michelle D. , Kral Mary C. , Boan Andrea D.
Published: October 2015

Treatment effectiveness between equivalent doses of non-OROS (osmotic controlled release oral delivery system) methylphenidate ER and OROS methylphenidate ER (brand name Concerta) was examined in a clinical case series of children and adolescents followed for treatment of attention-deficit/hyperactivity disorder (ADHD). The Conners-Third Edition: Parent Rating Scale was used to compare ADHD symptoms when patients were taking non-OROS versus OROS at follow-up visits. A repeated-measures mixed-model approach was used to compare treatment effectiveness. The entire sample (N = 14) demonstrated a reduction in the mean score on the Inattention Scale from clinically significant (T-score > 65) to not clinically significant (T-score < 65) when patients were changed from non-OROS to OROS at the same dosage (mean T-score reduction = 23, p < .0001). The reduction in mean T-score after changing from non-OROS to OROS at the same dosage is indicative of improvement in symptoms of ADHD. Results provide empirical support for US Food and Drug Administration concerns regarding the therapeutic equivalence of non-OROS versus OROS for the treatment of ADHD.