bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Lineage Traces the Differentiation Fate of Epicardial Cells during Heart Development
Authors:   College of Life Science and Technolog, Jinan University, Guangzhou, 510632, Guangdong, China, Lu FR , Yang XJ ,   College of Life Science and Technolog, Jinan University, Guangzhou, 510632, Guangdong, China
Published: March 2024

Objective: The genetic lineage tracing method was used to examine the Epithelial-Mesenchymal Transition (EMT) process and the contribution of epicardial cells to mesenchymal cells at various stages of fetal heart development. Methods: In Wt1-CreER; R26-tdTomato transgenic mice, tamoxifen was utilized to promote the tagging of epicardial cells with tdTomato fluorescence at E10. At E11.5, E12.5, and E16.5, embryonic hearts were harvested and photographed using confocal fluorescence microscopy and stereomicroscopy. Results: According to the findings, the tdTomato+ cells at E11.5 were still in the epicardium and had not yet moved into the myocardium. Epicardial cells began to separate from the epicardium and give rise to epicardial-derived cells at embryonic day 12.5 (E12.5). On the valve primordium, fibroblasts generated from epicardium have been found. By E16.5, many epicardial cells had moved into the myocardium and formed fibroblasts, mesenchymal cells, vascular smooth muscle cells, as well as migrated into the ventricular septum and valves, contributing to their growth and creation. Conclusions: The contribution of epicardial cells to mesenchymal cells during development is shown by genetic lineage tracing, opening up possibilities and offering references for creating relevant treatment approaches based on epicardial cells.
An Unusual Bilateral Cicatrizing Conjunctivitis in Severe Ocular Rosacea: Case Report
Authors:   Department of Ophthalmology, Hopitaldes Spécialités, Rabat, Morocco, H Elbelidi , Y Saoiabi ,   Department of Ophthalmology, Hopitaldes Spécialités, Rabat, Morocco, L Cherkaoui ,   Department of Ophthalmology, Hopitaldes Spécialités, Rabat, Morocco
Published: March 2024

Rosacea is a chronic progressive disease of unknown cause that affects the eyes and facial skin. Ocular rosacea is often missed when ophthalmologists do not adequately examine a patient’s face during eye exams. If treatment is delayed due to undiagnosed rosacea, serious eye complications and blindness can occur. We present a case of 35-year-old female, followed up for rosacea and severe depressive disorder, presented with bilateral, symmetrical blinding cicatricial conjunctivitis after neglected ocular self-injury.
Frequency of Microorganisms in Septic Arthritis in Children Under the Age of 10 Years
Authors:   Department of Orthopedic and Trauma, Medical Teaching Institute Lady Reading Hospital Peshawar, Pakistan., Inam Muhammad , Ahmad Ziyad ,   Department of Orthopedic and Trauma, Medical Teaching Institute Lady Reading Hospital Peshawar, Pakistan., Zaman Ronaq ,   Department of Orthopedic and Trauma, Medical Teaching Institute Lady Reading Hospital Peshawar, Pakistan., Khan Imran ,   Department of Orthopedic and Trauma, Medical Teaching Institute Lady Reading Hospital Peshawar, Pakistan., Ali Mian Amjad ,   Department of Orthopedic and Trauma, Medical Teaching Institute Lady Reading Hospital Peshawar, Pakistan., Shabir Muhammad ,   Department of Orthopedic and Trauma, Medical Teaching Institute Lady Reading Hospital Peshawar, Pakistan.
Published: March 2024

Background: Septic arthritis is an infrequent disease although very important due to the possibility of disastrous outcomes if treatment is not adequately established. Adequate information concerning the epidemiology of septic arthritis is still lacking. Objective: To find determine the frequency of various microorganisms in septic arthritis in children under age of 10 year. Materials and Methods: This Cross-Sectional Study was conducted in the Department of Orthopedics and Trauma, Medical Teaching Institute Lady Reading Hospital Peshawar Pakistan on from September 2022 to March 2023 on 171 consecutive patients. Non Probability Consecutive Sampling Technique was used in the study. Sample size was calculated using WHO sample size formula, using the proportion, anticipated frequency of E. coli, p=8%3, Margin of error=7.5%, Confidence Level=95%. Patient age 1 month to 10 years of both genders presenting with septic arthritis as per operational definition were included in the study while Patients with congenital joint deformity, Immunocompromised patients, Patients with rheumatologic joint disease and Patients with traumatic joint injury were excluded from the study. Septic arthritis was confirmed with clinical fever, pain and tenderness in the joint and ultrasound showing collection and debris in the joint cavity. Synovial fluid was aspirated for C/S. Pattern of microorganisms in the growth in the culture was noted. Results: Mean age of the patients was 6.68±1.239 years. Out of 177 patients, 96 (%) were male. Large joint arthritis was more common (63.8%). Staph aureus was the most common microorganism isolated in 79 patients (44.6%) while E coli was least commonly isolated (28 patients, 15.8%). Conclusion: S. aureus is still the most common pathogen in acute joint infections in our environment in children under the age of 10 years.
Case Report-A Rare Congenital Lung Defect
Authors:   Department of Thoracic Surgery, Red Cross General Hospital, Athens, Greece, Simoglou Christos , Bertus Igner ,   Department of Cardiothoracic Surgery Universital Hospital of Bristol, UK
Published: March 2024

A 72 year old male smoker presented with haemoptysis and recurrent pneumonias. Chest CT showed an emphysematous cyst and air-fluid level cavities in the left lower lobe, (Figure 1). A left lower lobectomy was performed. Intraoperative finding was an intralobar sequestration. Histopathology revealed the presence of adenocarcinoma within the sequestrated lobe.
Retrospective analysis of exporting agricultural processing industry products
Authors: Lisachkina Yu. S.
Published: March 2024

The Russian exports of processed food products analysis since 2014 has revealed a stable growth in this area, corresponding to the general dynamics of domestic agricultural products sales in the world market. At the same time, the share of processed food products in the total volume of domestic exports from 2014 to 2021 increased from 1.7 to 3.1%, which is a favorable factor in reducing the mineral-raw materials orientation of Russia’s foreign trade. The increase in processed products exports contributes to the export-oriented nature of the domestic food industry, which grew from 6.5 to 11.6 % over the period. This is also due to the fact that import substitution programs development and competitive imports limitation after the counter-sanctions introduction in 2014-2015 had a favorable impact on the food industry and allowed to maintain and increase a number of export directions. Over the past few years, the key areas of sales in the global market have been the products of the oil and fat and sugar beet industries. Along with the sale of finished products, the food industry wastes export, which are raw materials for fodder production, is also considered important. With the overall positive dynamics of processed food sales, the only direction showing a decrease in exports is tobacco and tobacco products. The reduction in tobacco products exports is explained by the change in the transnational corporations policy who own the Russian cigarette business, which, in addition to the Russian market, until 2014 also partially filled the markets of the Commonwealth of Indepen dent States and Eastern Europe countries.
Shifting the focus of world industrial development from European countries and North America to Asia
Authors: Ivanchenko A. V.
Published: March 2024

Industry is the basis of economic development, therefore, studying the real sector allow us to assess the physical scale of the economy of individual countries and the world as a whole. The industrial production structural distribution by countries and macro-regions reflects the real balance of power in the global arena. Retrospective analysis allows us to see this process in dynamics, which contributes to the correct construction of models of further international cooperation, foreign trade and infrastructural development in this direction.

   The purpose of the study is to assess the dynamics of the industrial production shift from West to East in recent decades.

   The tabular, graphical and descriptive methods were used, and it allowed us to visualize the indicators retrospective analysis results. In the course of the work it has been proved that by now there is parity in the level of industrial production between the countries of the collective West and East. It makes it possible to change the term “developed countries” meaning and extend it not only to European and North American countries, but also to a number of Asian and Latin American countries due to the ever-growing importance of these countries’ industry on a global scale.
Non-bonded force field parameters from MBIS partitioning of the molecular electron density improve binding affinity predictions of the T4-lysozyme double mutant
Authors: Macaya Luis , González Duván , Vöhringer-Martinez Esteban
Published: March 2024

Binding affinity prediction using computer simulation has been increasingly incorporated in drug discovery projects. Its wide application, however, is limited by the prediction accuracy of the free energy calculations. The main error sources are force fields used to describe molecular interactions and incomplete sampling of the configurational space. To improve the quality of the force field, we developed a Python-based computational workflow. The workflow described here uses the Minimal Basis Iterative Stockholder method (MBIS) to determine atomic charges and Lennard-Jones parameters from the polarized molecular density. This is done by performing electronic structure calculations on various configurations of the ligand, both when it is bound and unbound. In addition, we have validated a simulation procedure that accounts for the protein and the ligand degrees of freedom to precisely calculate binding free energies. This was achieved by comparing the self-adjusted mixture sampling and non-equilibrium thermodynamic integration methods using various protein and ligand conformations. The accuracy of predicting binding affinity is improved by using MBIS derived force field parameters and the validated simulation procedure. This improvement surpasses the chemical precision for the eight aromatic ligands reaching a root mean square error (RMSE) of 0.7 kcal/mol.
Machine Learning, Divergent Syntheses, and X-ray Analyses of Dithienobenzothiazole-based Semiconductors Controlled by S•••N and S•••S Interactions
Authors: Ogaki Takuya , Matsui Yasunori , Okamoto Haruki , Nishida Naoyuki , Sato Hiroyasu , Asada Toshio , Naito Hiroyoshi , Ikeda Hiroshi
Published: March 2024

Inspired by the previous machine-learning study that the number of hydrogen-bonding acceptor (NHBA) is important index for the hole mobility of organic semiconductors, we synthesized seven dithienobenzothiazole (DBT) derivatives 1a–g (NHBA = 5) by one-step functionalization from a common precursor. X-ray single-crystal structural analyses confirmed that the molecular arrangements of 1b (the diethyl and ethylthienyl derivative) and 1c (the di(n-propyl) and n-propylthienyl derivative) in the crystal are classified into brickwork structures with multidirectional intermolecular charge-transfer integrals, as a result of incorporation of multiple hydrogen-bond acceptors. The solution-processed top-gate bottom-contact devices of 1b and 1c had hole mobilities of 0.16 and 0.029 cm2 V–1s–1, respectively.
Synthesis of γ-butyrolactone hybrid imidazo[2,1-b][1,3]-thiazoles from limonene
Authors: Kaur Pushpinder , Das Pralay , Singh Bikram
Published: March 2024

The substituted γ-butyrolactones are important structural motifs in several natural products and pharmaceuticals. In this paper γ-butyrolactone fused heterocyclic imidazo[2,1-b][1,3]-thiazole derivatives have been synthesized from thiazole amine (4) and different substituted α-bromo acetophenones in moderate yields. Electron rich substituents provided higher yields of the desired products. The screening results of physicochemical properties indicated that all the synthesized heterocyclic molecules could be good drug candidates.
Larval mantis shrimp Rissoides desmaresti (RISSO, 1816) (Stomatopoda) in the Belgian part of the North Sea
Authors: Vansteenbrugge Lies , Van Ginderdeuren Karl , Van Regenmoortel Tina , Hostens Kris , Vincx Magda
Published: March 2024

Short notes don’t have an abstract.
Electronic Commerce Security and Risk Management: An Important Part of College Curriculum
Authors: Cai Yongchang
Published: March 2024

With the rapid expansion of e-commerce, its security and risk management problems become increasingly prominent. In the current business environment, the ability to understand and apply e-commerce security and risk management has become an important criterion to measure a good person. Therefore, the importance of e-commerce security and risk management courses in college education is self-evident. This course can not only help students master the basic knowledge of e-commerce, but also enable them to understand how to deal with various risks in practical work and ensure the safe operation of e-commerce. At the same time, through the study of e-commerce security and risk management, students can better understand the operation mode and law of e-commerce, and lay a solid foundation for their future career. In general, e-commerce security and risk management occupy an important position in the curriculum of colleges and universities, and play a crucial role in cultivating e-commerce professionals with practical operation ability and innovative thinking.
Perhubungan Terorisme dengan Kejahatan Transnasional: Crime-Terrorism oleh Kelompok Abu Sayyaf di Filipina
Authors: Maulidita Salismi Zulfi , Novita Fauziah , Hikmah Indah Putri
Published: March 2024

Bersamaan dengan genosida dan kejahatan melawan hak asasi manusia, terorisme tergolong sebagai tindak kejahatan luar biasa. Seperti tindak kejahatan lainnya yang selalu dinamis mengikuti perkembangan sosial dan zaman, terorisme juga mengalami hal yang sama. Di era kontemporer ini, terdapat banyak kemungkinan dimana kelompok terorisme tidak lagi hanya berfokus pada misi dan atribut yang melekat pada mereka, tetapi juga membuat koneksi bahkan bekerjasama dengan kelompok kejahatan transnasional, konsep ini disebut oleh Rollins dan Wyler sebagai crime-terrorism. Dalam penelitian ini, peneliti mengangkat Kelompok Abu Sayyaf sebagai subjek utama dan berusaha untuk menganalisa bagaimana Kelompok Abu Sayyaf sebagai organisasi terorisme membangun hubungan dengan kelompok kejahatan terorganisir hingga bahkan melaksanakan kejahatan transnasional itu sendiri, merujuk pada konsep crime-terrorism oleh Rollins dan Wyler. Peneliti menggunakan menggunakan metode penelitian kualitatif oleh Miles dan Hubberman dalam melangsungkan penelitian. Hasil dari penelitian ini, yaitu; Motivasi Kelompok Abu Sayyaf untuk bekerjasama dan melakukan kejahatan terorganisir yaitu guna memenuhi dana operasional dan kebutuhan hidup anggotanya setelah aliran dana dari sponsornya terputus. Sedangkan Apropriasi Taktik yang dilakukan oleh Abu Sayyaf yaitu dengan melakukan serangan bom, penculikan dan pemerasan, dan penyediaan keamanan untuk budidaya dan perdagangan ganja ilegal.
Pengaruh Atribut Nasional terhadap Kebijakan Cina Bersengketa dengan Jepang di Kepulauan Diaoyu/Senkaku
Authors: Karang Christoforus , Abil Adam , Sharon Maria , Pratama Ananda , Gracia Rafaela
Published: March 2024

Kebijakan luar negeri Cina kerapkali sulit dipahami dengan baik, karena terjadi ambiguitas dalam menentukkan instrumen-instrumen yang tepat dalam memperjuangkan keinginannya. Melalui penelitian ini, kami berusaha mencermati dan menganalisis kebijakan luar negeri Cina dalam sengketa dengan Jepang di Kepulauan Diaoyu/Senkaku. Ketika dilihat secara normatif, kebijakan luar negeri Cina untuk menguasai Kepulauan Diaoyu/Senkaku tidak dapat dilakukan karena Cina telah menjadi negara pihak dalam UNCLOS pada tahun 1996. Walaupun begitu, kebijakan Cina kini yang mempersengketakan Kepulauan ini, menjadi nyata bahwa Cina seolah tidak memperhatikan aspek normatif yang telah dilakukannya sebelumnya. Dengan demikian, penelitian ini akan menganalisis kebijakan Cina yang cenderung konfrontatif dengan Jepang dan melalui instrumen teori Atribut Nasional oleh Valerie Hudson dapat diketahui intensi Cina ini.    

Kata Kunci: Diaoyu; Senkaku; Cina; Jepang; Atribut Nasional
Keketuaan ASEAN dan Potensi Diplomasi Indonesia dalam Penyelesaian Konflik di Myanmar
Authors: Ain Wan Nur , Wulandari Sephia Dwi Meilinda
Published: March 2024

Sebagai pemegang keputusan tertinggi ASEAN satu tahun kedepan, Indonesia harus mampu menyikapi tantangan dalam kawasan, termasuk konflik Myanmar yang hingga saat ini masih memanas. Lima konsensus yang disepakati ASEAN tahun 2021 sebagai upaya damai di Myanmar, masih terkesan lemah untuk menopang perdamaian. Kondisi serupa juga pernah dialami oleh Indonesia di tahun 1976-2005 yaitu konflik antara Gerakan Aceh Merdeka (GAM) dan Indonesia yang berhasil didamaikan melalui kesepakatan MoU Helsinki yang dicetus oleh Wakil Presiden Jusuf Kalla dan dimediasi oleh Presiden Finlandia Martti Ahtisaari, perwakilan Uni Eropa dan anggota ASEAN. Artikel ini bertujuan untuk menjelaskan bagaimana Indonesia dapat memanfaatkan potensi diplomasinya dalam memfasilitasi perdamaian untuk Myanmar pada era keketuaannya di ASEAN, dengan bercermin pada keberhasilan Indonesia dalam konflik antara GAM dan Indonesia. Penelitian dalam artikel ini menggunakan metode penelitian pustaka dengan menggunakan artikel jurnal, laporan, perundang-undangan pemerintah dan organisasi internasional yang telah dipublikasi melalui website resmi mereka. Hasil temuan yang disajikan penulis yaitu Indonesia seharusnya mampu memanfaatkan posisinya sebagai ketua ASEAN dengan mengoptimalkan diplomasi melalui dialog seluas-luasnya dalam penyelesaian konflik Myanmar, seperti yang terjadi di Aceh.
Kata Kunci: ASEAN; Indonesia; Myanmar; Konsensus; Diplomasi
STRATEGI PENGEMBANGAN AGRIBISNIS NILAM DI DESA ONDO ONDOLU KABUPATEN BANGGAI
Authors: Hasan Wahyudi
Published: March 2024

Abstract Patschouli oil gives contribution enough big in state's stock exchange producer among other essential oils. But produce of patschouli oil in Indonesia still be limited and its(the production has not optimal. Patschouli oil is export commodity non migas.Requirement of essential oils world would coming from sapphire crop now shifts 600 - 800 tonnes/year. Most of this requirement supply Indonesian.In world essential oils marketing, Indonesia essential oils recognized to be best and masters market share around 80% - 90% is coming from sapphire. Remembers existence and market opportunity which still promising, hence agribusiness and sapphire market must be managed carefully.Purpose of research is system evaluation of marketing to expansion and of agrbisnis sapphire in the village Ondo ondolu causing can determine srategi what applied for its(the expansion is to the fore.Research is done near byly qualitative and is descriptive, Analysis applied is analysis SWOT to see strength, weakness and exploits opportunity to develop sapphire agribusiness in the village Ondo Ondolu District Batui Sub-Province Banggai.From analyst result which in getting where internal factor and eksternal stays at quadrant IV with axis 3,11 and 4,00 is burdens that sapphire agribusiness in the village Ondo ondolu District Batui mops is big for in developing. Keyword : essential oils, patchouli, agribusiness.
PERAN PENYULUH PERTANIAN DALAM MENINGKATKAN KESEJAHTERAAN DAN TARAF HIDUP PETERNAK SAPI POTONG DI KELURAHAN PASIR PUTIH KECAMATAN SINJAI BORONG
Authors: Makmur Makmur , Fitrawansyah Fitrawansyah , Sofyang Sofyang
Published: March 2024

Peran penyuluh pertanian dalam meningkatkan kesejahteraan dan taraf hidup peternak sapi potong di Kelurahan Pasir Putih Kecamatan Sinjai Borong.Penelitian ini bertujuan untuk mengetahui tingkat peran penyuluh pertanian yang ada di kelurahan Pasir Putih Kecamatan Sinjai Borong. Penelitian dilaksanakan pada bulan Agustus – oktober tahun 2022, bertempat di Kelurahan Pasir Putih Kecamatan Sinjai Borong.Penelitian ini menggunakan analisis deskriptif. Untuk menganalisis karakteristik peternak responden menggunakan analisis deskriptif. Untuk menganalisis peran penyuluh pertanian dalam meningkatkan kesejahteraan dan taraf hidup peternak sapi potong menggunakan skala likert.Jumlah sampel sebanyak 80 orang peternak.Hasil analisis menunjukkan bahwa penyuluh pertanian dalam peran sebagai edukator berada pada kategori sangat rendah,  peran sebagai motivator dan komunikator berada dalam kategori sedang.
Epidemiology of giant cell arteritis in Waikato, Aotearoa New Zealand
Authors: van Dantzig Philippa , Quincey Vicki , Kurz Jason , Ming Caroline , Kamalaksha Sujatha , White Douglas
Published: March 2024

aim: Giant cell arteritis (GCA) is the most common primary vasculitis in adults over 50 years of age. Our primary objective was to assess the incidence and prevalence of GCA in Waikato in a bid to deepen our understanding of the epidemiology of GCA in Aotearoa New Zealand. methods: From January 2014 to December 2022, cases of GCA were identified prospectively and retrospectively through temporal artery ultrasound request lists and temporal artery biopsy histology reports. Using electronic health records, data were collected retrospectively on patient demographics and clinical features. These were used to calculate the incidence, prevalence and standardised mortality ratio (SMR) of GCA in Waikato. results: There were 214 patients diagnosed with GCA over the 9-year period. The majority of patients were European (93.9%, 201/214) with Māori patients being significantly younger than European patients. The mean annual incidence of clinical GCA was 14.7 per 100,000 people over 50 years (95% confidence interval [CI] 12.7–16.6). The SMR was 1.18 (95% CI 0.83–1.52). conclusion: This is the largest study to date on the epidemiology of GCA in Aotearoa New Zealand. The incidence of GCA is comparable to other studies performed in Aotearoa New Zealand and appears to be stable over time. GCA is uncommon in Māori, Pacific Islander and Asian ethnic groups.
Clinical Evaluation of Enteral Nutrition + Probiotics in the Treatment of Gastrointestinal Dysfunction After Severe Traumatic Brain Injury
Authors: Zhang Lianyu
Published: March 2024

Objective: To evaluate the therapeutic effect of enteral nutrition + probiotics in patients with gastrointestinal dysfunction after severe craniocerebral injury. Methods: From September 2018 to February 2023, 80 patients (20–82 years old) with gastrointestinal dysfunction who were admitted to the Intensive Care Unit at the Third People’s Hospital of Xining were included in the study. Their primary condition was severe craniocerebral injury, and all of them received conventional symptomatic treatment. Group A received enteral nutrition + probiotic therapy, whereas group B received enteral nutrition only. The differences in the following indicators were compared before and after treatment: nutritional and biochemical indicators, gastrointestinal function indicators, Glasgow Coma Scale (GCS), Sequential Organ Failure Assessment (SOFA), APACHE II score, serum procalcitonin (PCT), neutrophil (N) ratio, and C reactive protein (CRP). Result: The nutritional and biochemical indicators in group A were higher than those in group B, P < 0.05; the time to first passage of flatus, time to first passage of stool, and bowel sound recovery time in group A were shorter than those in group B, P < 0.05; the GCS of group A was higher than that of group B, P < 0.05; the SOFA and APACHE Ⅱ scores of group A were not different from those of group B, P > 0.05; and the PCT, N ratio, and CRP levels of group A were lower than those of group B, P < 0.05. Conclusion: In patients with gastrointestinal dysfunction after severe craniocerebral injury, enteral nutrition + probiotic therapy is highly effective and feasible, as it can optimize various nutritional indicators, shorten the gastrointestinal function recovery time, and reduce the body’s stress response.
Progress of Research on the Effect of Dietary Care on Patients with Gastritis and Gastric Ulcers
Authors: Li Aijing
Published: March 2024

Gastritis gastric ulcer is a common disease of the digestive system, which has a serious impact on the quality of life and health of affected individuals. Dietary care is one of the important measures to treat and prevent gastritis gastric ulcers. This paper reviews the research progress on the impact of dietary care on patients with gastritis and gastric ulcers, including dietary behavioral intervention, dietary habit cultivation, dietary hygiene education, and nutritional support. Studies have shown that rational dietary care was able to improve the clinical symptoms of patients, regulate the intestinal microbial community, anti-inflammatory, antioxidant, and other pathways to improve the pathophysiological state of patients with gastritis and gastric ulcer and prevent recurrence. Therefore, dietary care is of great significance to patients with gastritis and gastric ulcers.
Evaluation of the Application Effect of Enteral and Parenteral Nutrition Therapy Combined with a Health Belief Education Model in Patients with Inflammatory Bowel Disease
Authors: Chen Yangyan
Published: March 2024

Objective: To evaluate the application effect of enteral and parenteral nutrition therapy combined with a health belief education model in patients with inflammatory bowel disease. Methods: 80 patients with inflammatory bowel disease admitted to the Shanghai Zhangjiang Institute of Medical Innovation were chosen. This study was carried out from August 2022 to October 2023. The patients were randomly divided into a study group (40 cases) and a control group (40 cases). The treatment plan for the control group was the conventional treatment model, while the treatment plan for the study group was to provide enteral and parenteral nutrition therapy combined with a health belief education model based on the control group. The efficacy of both groups was compared. Results: In the study group, the therapeutic effect for 31 patients (77.50%) was markedly effective and 7 was effective (17.50%), accounting for 95.0% of the total, which was higher than the control group at 80.0% (P < 0.05). The relief time of relevant symptoms in the study group was shorter than that of the control group (P < 0.05). Before treatment, there were no differences in the high-sensitivity C-reactive protein (hs-CRP), interleukin 10 (IL-10), and tumor necrosis factor- α (TNF-α) between both groups (P > 0.05). After treatment, the levels of inflammatory factors in the study group (hs-CRP (8.02 ± 1.13) mg/L, IL -10 (9.24 ± 1.25) pg/mL, and TNF-α (7.19 ± 1.04) ng/L) were lower than those in the control group (P < 0.05). Conclusion: Enteral and parenteral nutritional therapy combined with a health belief education model showed significant efficacy in inflammatory bowel disease patients. Patient symptoms were relieved and inflammatory reactions were reduced. This method is worthy of popularization.
Overview of Healthcare-Related Infections in Intensive Care Units of a public hospital
Authors: Garcez Marília Victória Nunes Garcez , Campelo Sônia Maria de Araújo , Ribeiro Ivonizete Pires , Barros Gabriel Martins de Barros , Silva Anneth Cardoso Basílio da , Costa Francimar Lima da , Lima Andréa Conceição Gomes , Avelino Fernanda Valeria Silva Dantas
Published: March 2024

Introduction: Healthcare-Associated Infections are illnesses acquired after the patient's admission to the hospital unit and which manifest themselves during hospitalization or after discharge. Aim: To analyze the panorama of health-related infections in patients admitted to intensive care units. Outlining: Cross-sectional, retrospective study, collected from the Hospital Infection Control Commission database in a public hospital from July to December 2022. Crude and adjusted odds ratios were calculated using logistic regressions. The study followed the ethical and legal precepts of resolution 466/2012. Results: There was a predominance of males and those aged over 60 years. The main clinical problems were co infection with COVID-19 and co-infection with HIV. Regarding previous conditions, Systemic Arterial Hypertension stood out. When analyzing the etiological agents, the presence of Klebsiella pneumoniae showed a marginally significant association with an increase in the chances of death. Implications: The use of invasive devices, prolonged hospital stay and other factors such as age, associated comorbidities, were predictors of mortality among patients, as well as risk factors for the development of Klebsiella Pneumoniae Carbapenemase infection.
Evaluation of the antifungal effect and adhesive strength of a denture adhesive supplemented with nystatin
Authors: Cristina Alvim Graziele , Beatriz da Silva Camilla , De Cássia Oliveira Viviane , Cândido dos Reis Andréa , Watanabe Evandro , Penazzo Lepri César , Tornavoi de Castro Denise
Published: March 2024

Introduction: The scientific basis related to the effect of incorporating antifungals on the properties of denture adhesives is scarce. This study incorporated an antifungal agent into an adhesive and evaluated the influence on biofilm formation and adhesive strength. Design: Specimens in resin based on polymethylmethacrylate (PMMA) were divided into groups: PMMA (No Adhesive); PMMA+Ultra Corega Cream Adhesive and PMMA+Ultra Corega Cream Adhesive+Nystatin. Biofilm of Candida albicans was grown on the specimens and the cell viability was investigated by counting colony forming units (CFU/mL). Adhesive strength was tested after 5 minutes, 6 and 12 hours. For microbiological analysis, data were evaluated by Kruskal-Wallis and Dunn's post test, and for analysis of adhesive strength by two-way ANOVA and Bonferroni post test (α=.05). Results: There was a reduction in biofilm formation on the surface of the nystatin-modified adhesive (p<.001). After 5 minutes, the adhesive strength of the modified Ultra Corega Cream was greater than that of the commercial product (p=.048), with no significant difference in the other times (p>.05). Implications: The incorporation of nystatin on denture adhesive reduced biofilm accumulation, with a positive influence on the initial adhesive strength, it may be a viable alternative for delivering the drug to the patient.
Analisis Pengembangan Wisata Golden Prawn Dan Pengaruh Peningkatannya Terhadap Konservasi Lingkungan Dan Keberlanjutan Di Kepulauan Riau
Authors: Azali Dara Larasati , Sulistiana Vina
Published: March 2024

Tourism in the Riau Islands is rapidly growing, with Golden Prawn as a major destination attracting many visitors. This research aims to analyze the development of Golden Prawn tourism and its impact on environmental conservation and sustainability in the region. The research method used is qualitative, descriptive, and analysis 3A with data collection through interviews, field observations, and literature review.The results show that Golden Prawn has experienced a significant increase in visits in recent years. Further development potential is evident from market demand and the natural potential in its surroundings. However, this development also brings environmental impacts, such as ecosystem degradation and increased waste.In the context of sustainability, the contribution of Golden Prawn to the local economy and cultural preservation is crucial. However, further efforts are needed to mitigate negative environmental impacts. This research provides recommendations for tourism managers and local governments to integrate sustainability principles into the development and management of Golden Prawn.
Qualitative Behavior for a Discretized Conformable Fractional-Order Lotka-Volterra Model With Harvesting Effects
Authors: Berkal Messaoud , Navarro Juan F. , Almatrafi M. B.
Published: March 2024

The predator-prey model is a widely mathematical structure that explains the dynamics between two interacting populations: predators and prey. The predator-prey interaction represents a fundamental dynamic in nature, influencing the stability and balance of ecosystems worldwide. The purpose of this article is to provide insight into the complex interactions and feedback mechanisms between predators and prey in ecological systems via mathematical tools such as stability and bifurcation. We investigate a fractional-order Lotka-Volterra model with a harvesting effect using stability and bifurcation theory. The equilibrium points and local stability of the purposed model are presented in this article. The bifurcation analysis, which is a potent approach used to analyse the qualitative behavior of the predator-prey system as the parameter values are varied, is also explored. In particular, a Neimark-Sacker bifurcation and a period-doubling bifurcation are theoretically and numerically examined. Furthermore, we illustrate some 2D figures to show the phase portriat and bifurcations of this model at various points.
Psychological culture of formation of personal dignity, safety of life and civic position in students of 5-6 grades
Authors: Tsiuman T. , Reva О.
Published: March 2024

The article presents a theoretical and methodological analysis of the main scientific approaches to the definition of psychological culture in domestic and foreign psychology, focuses on conceptual ideas regarding the substantiation of the psychological content of the formation of personal dignity, life safety and civic position in pupils of 5-6 grades. The content of the concept of psychological culture as an important tool for human adaptation in a constantly changing social environment and a guarantee of self-realization of the individual at different stages of development is revealed. The author's approaches to the phenomenon of psychological culture of the individual in the formation of personal dignity, life safety and civic position are substantiated. The features and recommendations for using the system of educational work through the formation of intrinsic motivational attitudes, important life skills, development of personal and civic competencies in younger adolescents are characterized. It is emphasized that a teacher who has a psychological culture can become a model of a self-sufficient personality for younger adolescents in matters of personal dignity, life safety and civic position.
Individual trajectory of professional improvement of a teacher: results of scientific research
Authors: Boychenko V.
Published: March 2024

The article presents the results of scientific research aimed at studying theoretical research and practical solutions focused on the design and implementation of the individual trajectory of professional improvement of teachers.

The purpose of this article is to outline theoretical approaches and practical solutions for the professional improvement of teachers in the system of postgraduate pedagogical education.

The task of the article is to clarify the meaning of the concepts of "professional improvement of the teacher" and "individual educational trajectory" based on the analysis of domestic and foreign researches; identify key contradictions in the practice of designing and implementing the individual educational trajectory of professional improvement of teachers in the system of postgraduate pedagogical education; determine the directions of further scientific research in theory and practice.

As a result of the research, leading approaches to the professional development of teachers were clarified; clarified the content of the key concepts "professional improvement of the teacher" and "individual educational trajectory"; outlined the results of a number of experimental researches, including in the system of postgraduate pedagogical education in Kyiv..

Based on the analysis, the directions of further scientific research have been determined, which will focus on the theoretical justification and experimental verification of the model of designing the individual trajectory of the professional improvement of teachers, the development and testing of tools for individualization of professional improvement in the system of postgraduate education.
Experience of inclusive education in Hungary
Authors: Reho H.
Published: March 2024

In comparison with the trends of the previous decades, the educational process in state educational institutions has witnessed a significant increase in the number of children with special educational needs and features of psychophysical development. The military situation in Ukraine has made the issue of inclusive education more urgent.

In Hungary, the emergence of two laws in the 1990s, namely Law LXXIX "On Education" of 1993, and Law XXVI "On the Rights of Persons with Disabilities and Ensuring Their Equal Opportunities" of 1998, opened new possibilities and posed new challenges to the teaching profession. Consequently, when making decisions and taking measures related to children, educators are required to treat them equally. The demand for equal treatment of all children enhances the quality of life for individuals with disabilities, enabling them to become active members of society, just like their healthy peers.

Our research is not representative, and the obtained results are indicative.

The purpose of the research was primarily to gain an understanding of the state of inclusive education in Hungary and lay the foundations for a more comprehensive research to borrow experience.

Tasks. Based on interviews with researchers who work in the field of inclusive education in preschools and practicing educators and heads of preschool institutions with inclusive groups, we tried to cover the experience of working with children with special educational needs and their parents in Hungarian preschools.

Brief Description of Research Results. Social circumstances that are constantly evolving prompt all members of the educational process, particularly educators in preschool institutions, towards adaptability, resilience, self-reflection, the renewal of educational practices and approaches, partnership among all members, and the utilization of new methods and tools. The research indicated that, from both a social and economic perspective, "investing in early childhood is a 'return on investment' in the literal sense of the word," significantly impacting their future beyond school preparedness. However, while adapting to the changing demands of society, it is crucial for preschool institutions to maintain their child-oriented focus and traditional pedagogical practices.

Conclusions. In terms of the obtained results, it can be stated that for inclusive education to work successfully and yield desired results, awareness, collaboration, and receptiveness of all members of the educational process – parents, children, and educators – are essential.
Preparation of future educators for pedagogical support of play activities of young children
Authors: Harashchenko L. , Litichenko O. , Shynkar T.
Published: March 2024

Relevance. Health-preserving competence is an important component of the professionalism of teachers of preschool education institutions and a necessary condition for the implementation of pedagogical support of early age children's play activities (outdoor games and play exercises).

The purpose of the study is to highlight the peculiarities of professional training of future educators for pedagogical support of play activities of early age children. The objectives are to determine the criteria and development level of qualification competence assessment for pedagogical support implementation of outdoor game, to analyze the content and technological components of students' professional training for pedagogical support of early age children's play activities.

Brief overview of the research results. It was revealed that students have certain difficulties in the implementation of play activities of early age children (play exercises for the movements development). Conclusions were drawn about the insufficient effectiveness of students' professional training for educational interaction with early age children in the field of physical education. This led to the necessity to improve the contents of the work program of the discipline "Health-Preserving Technologies in Preschool Education" for 012 Preschool Education students. As well as to improve the contents and methodological tools for conducting educational classes, that would reflect a unified systematic approach to the formation of professional competence of future educators in the field of physical education of early age children.

Conclusions. Improvement of the content of the program and educational classes, careful consideration of the task system and their quality implementation create the basis for the full mastery of the content component of the discipline for further professional activity with early age children.
Textual lacunae and the paradoxes of their interpretation
Authors: Prosalova Vira , Hryhoshkina Yaroslava
Published: March 2024

The article is devoted to textual lacunae, those paradoxes of unspokenness that arise when reading works of art and often lead to the discovery of different, completely opposite meanings in them, because the perception process is influenced by many factors: sociocultural context, social or professional affiliation of the reader, his / her life experience, age, gender, situation, etc. The relevance of this study is stipulated by the need to clarify different literary versions of the image of the main character from Leonid Mosendz’s novel “Roksoliana”, included in the collection “Liudyna Pokirna” (‘A Submissive Man’, 1937). The study is conducted by means of the receptive and hermeneutic research methods, that allowed to trace the difference in the filling of textual lacunae, which led to the fact that Ihor Nabytovych interprets the heroine as a traitor, Vira Prosalova – as a bride who seeks to save her beloved. The different perception of the main character’s image is determined by the author’s strategy: an appeal to the figure of the beloved wife of the Turkish Sultan Suleiman the Magnificent, the inclusion of a novel in the collection, the title of which sets the stage for a meeting with submissive characters and to some extent defines the type. The ambiguity in the work is also achieved by the reduction of important scenes, in particular the preparation and destruction of the Bolshevik headquarters, a break in the course of the plot (2 weeks of the absence of an eyewitness of the events), highlighting the image of the newest Roksolana only through the perception of the narrator, pointe as a genre feature of the novel, the incompleteness of the work, a stylistic figure of aposiopesis. The composition of this short story is based on the technique of syncresis, which confirms the author’s conscious intention not to dot the і’s and cross the t’s, but force the reader to draw a conclusion about the essence of patriotism and apostasy. The article focuses on those means of poetics that activate the reader’s attention, give space to his imagination, and therefore often lead to different readings, because the recipient fills in the gaps at his discretion. The conclusion is substantiated about the author’s conscious strategy, designed to draw attention to the figure of Roksolana, the reader’s involvement into the process of co-creation, and the potential openness of the artistic text for subsequent receptions.
Efficacy and Safety of Dpp-4 Inhibitor Use in the Hospital Setting
Authors: Dass Brendan
Published: March 2024

Current practice in the hospital is to hold oral antidiabetic drugs and administer insulin to prevent adverse reactions. This can lead to issues including hypoglycemic events, high glycemic variability, and poorly controlled blood glucose. Newer incretin analog drugs such as DPP-4 inhibitor do not cause hypoglycemia. A literature review was performed, and the results showed that DPP-4 inhibitors are both safe and effective in the inpatient setting with fewer hypoglycemic events, lower mean BG, and lower glycemic variability. The proposed study will compare patients with type diabetes treated with standard basal-bolus insulin therapy, against those continued on their home DPP-4 inhibitors on inpatient medical-surgical units at a single center to evaluate safety and efficacy of the different treatment modalities. A clinical support resource to better assist providers to treat type II diabetes will also be disseminated and include situations where DPP-4 inhibitor use would be contraindicated, or additional considerations such as holding a dose on the morning on surgery. The goal is for either improved or non-inferior outcomes in the treatment group in measures including mean blood glucose, hypoglycemic events, readings of poorly controlled blood glucose (>200 mg/dL) or hyperglycemic events (>350 mg/dL), and glycemic variability. Implications for APRN practice include adding to research findings supporting DPP-4 inhibitor use in the hospital, education of providers and patients, adopting the clinical decision-making tool into practice, and modifying hospital policy to reflect study findings.
Mathematical modelling of the Ebola virus disease.
Authors:   , Abdalla Suliman Jamiel Mohamed
Published: March 2024

Despite the numerous modelling efforts to advise public health physicians to understand the dynamics of the Ebola virus disease (EVD) and control its spread, the disease continued to spread in Africa. In the current thesis, we systematically review previous EVD models. Further, we develop novel mathematical models to explore two important problems during the 2018-2020 Kivu outbreak: the impact of geographically targeted vaccinations (GTVs) and the interplay between the attacks on Ebola treatment centres (ETCs) and the spread of EVD. In our systematic review, we identify many limitations in the modelling literature and provide brief suggestions for future work. Our modelling findings underscore the importance of considering GTVs in areas with high infections. In particular, we find that implementing GTVs in regions with high infections so that the total vaccinations are increased by 60% decreases the cumulative cases by 15%. On the other hand, we need to increase the vaccinations to more than 1000% to achieve the 15% decrease in EVD cases if we implement GTVs in areas with low infections. On the impact of the attacks on ETCs, we find that due to the attacks on ETCs, the cumulative cases increased by more than 17% during the 2018-2020 Kivu outbreak. We also find that when 10% of the hospitalised individuals flee the attacks on ETCs after spending only three days under treatment, the cumulative cases increased by more than 30% even if these individuals all returned to the ETCs three days later. On the other hand, if only half of these individuals returned to ETCs for treatment, the cumulative cases increase by approximately 50%. Further, when these patients spend one more day in the community, after which they all return to ETCs, the cumulative cases rise by an additional 10%. Global sensitivity analysis also confirmed these findings. To conclude, our literature systematic review is used to identify many critical factors which were overlooked in previous EVD models. Our modelling findings show that the attacks on ETCs can be destructive to the efforts of EVD response teams. Hence, it is important for decision-makers to tackle the reasons for community distrust and address the roots of the hostility towards ETCs. We also find that GTVs can be used to contain the spread of EVD when ring vaccinations, contact tracing and antiviral treatments cannot successfully control the spread of EVD.