bluuebunny/crossref_metadata_2025 huggingface dataset:
Abuse of Right to Repudiation and Unilateral Amendment of Terms and Conditions of an Obligation
Authors: Efimov Anatoly V. ,   Associate Professor of the Department of Entrepreneurial and Corporate Law of the Russian State University of Justice
Published: July 2024

The right to unilaterally withdrawal an obligation and unilaterally change its terms may be provided for by law or contract. At the same time, the exercise of this right may violate the principle of prohibition of abuse of rights. In this regard, within the framework of judicial enforcement, it is necessary to examine the goals, methods of exercising the right to unilateral withdrawal (change of obligation), as well as the general context of interaction between counterparties. Due to the absence of specific factors in positive law that would qualify the existence of an abuse of right, counterparties face significant risks when exercising their right to unilateral withdrawal (change of obligation). At the same time, a judicial assessment of actions for unilateral withdrawal (change of obligation) for the presence of abuse of right is seen as a necessary element of maintaining economic stability.
Disciplinary Liability as a Labor-Law Element of Professional Activities of Judges
Authors: Lukhovskaya Yulia O. ,   Postgraduate Student of the National Research University Higher School of Economics
Published: July 2024

The article determines the specifics of disciplinary responsibility as Labor Law element of the Judge’s professional activity. The author indicates inconsistencies in disciplinary responsibility of the Judge’s professional activity legal regulation in accordance with other employees, the necessity of exclusion the Judge’s disciplinary responsibility beyond working hours and with no any connection with labor function. It is noted that evaluation of the Judge’s ethical behavior should not be proceeded
Fundamentals of the Legal Status of the Supreme Council of Judicial Bodies and Authorities of the Arab Republic of Egypt
Authors: Solovyev Andrey A. ,   Deputy Presiding Judge of the Commercial Court of Moscow Region
Published: July 2024

The article deliberates on the basics of the legal status of the Supreme Judicial Council and Judicial Authorities and Bodies of the Arab Republic of Egypt, the essential judicial authority of the country which primary task is to guarantee independence of the judicial power. The author reviews the fundamentals of state structure of Egypt, with a special focus on the structure of the judicial system of the country, makes a retrospective journey into the history of formation and evolution of the bodies of the judicial community. Special attention is also given to the procedure of formation and main powers of the Supreme Judicial Council and Judicial Authorities and Bodies.
On the Legal Regulation of Non-Fungible Tokens in Russia
Authors: Schelokova Antonina A. ,   Postgraduate Student of the Belgorod University of Cooperation, Economics and Law
Published: July 2024

Currently the deals with tokenized art items and other intellectual property are widely discussed. Such objects are called non-fungible tokens, NFT. Because they are in demand, it is necessary to regulate NFT. Based on the analyses of the non-fungible tokens’ essence and notion, the author concludes, that such objects match the notion of digital rights, utility digital rights and, consequently, their legal regulation in Russia. It is advisable, according to the author’s opinion, that the term non-fungible tokens should be translated differently into Russian.
Transformation of the Content of the Theory of State and Law Course in the Conditions of Digitalization
Authors: Kolotkina Oksana A. ,   Associate Professor of the Department of Competition Law and Antimonopoly Regulation of the Ural State University, Yagofarova Inara D. ,   Associate Professor of the Department of Competition Law and Antimonopoly Regulation of the Ural State University
Published: July 2024

Purpose. This article actualizes the problem of transformation of the content of the thematic curriculum of the discipline “Theory of State and law”, in connection with the formation of a new concept of the digital state and the digital legal environment in the theoretical and legal science. Methodology: To conduct the research, such methods of scientific cognition as dialectical, analysis and synthesis, systemic, comparative legal, formal legal and other methods of scientific cognition were used. Conclusions. The content of the thematic plan of the discipline “Theory of State and law” needs to be updated in terms of reflecting new characteristics of state-legal phenomena in the conditions of digitalization. The basis for such an update is the results of scientific research on the impact of digital technologies on the form and content of individual elements of political and legal systems. In political and legal science, there is already a general idea of the characteristic features of the digital state, its essence, value, and the processes of digitalization taking place in the legal environment. In this connection, it seems extremely important to «implement» the achieved scientific results in this field in the content of the academic discipline “Theory of State and law”. Particular attention should be paid to updating the conceptual and categorical apparatus of the discipline. Scientific and practical significance. The conducted research will help accelerate the process of revising the content of the main issues of the course “Theory of State and Law”, as well as updating the conceptual and categorical apparatus of the discipline, with the help of which students should form an objective idea of the current state of state-legal phenomena in the conditions of digitalization. The conclusions obtained within the framework of the conducted research can be used by teachers of the academic discipline “Theory of State and Law” to update the content of individual questions of the course.
The Ural State Law University Named after V.F. Yakovlev: The History, the Present and Future
Authors: Bublik Vladimir A. ,   Rector of the Ural State Law University Named after V.F. Yakovlev, Honored Lawyer of the Russian Federation, Vinnitsky Andrey V. , Nasibullin Rafil A. , Smetanin Nikita V. , Fetyukov Fedor V. ,   Vice-Rector for Research, Head of the Department of Land,   Associate Professor of the Department of History of State and Law of the Ural State Law University Named after V.F. Yakovlev, PhD (History),   Head of the Project Office, Senior Lecturer of the Department of International Law of the Ural State Law University Named after V.F. Yakovlev,   Head of the Research Directorate, Associate Professor of the Department of Theory of State and Law of the Ural
Published: July 2024

The article describes the historical milestones in the formation of the Ural State Law University named after V.F. Yakovlev, characterizes the current state of development and gives a strategic vision of the future development of the university.
On Special Aspects of Budgetting Relations in an Organization
Authors: Yulberdina Lira R. ,   Senior Lecturer of the Department of Civil Law and Procedure of the Sterlitamak Branch
Published: July 2024

The article analyzes organizational budgetary legal relations; their author's classification was carried out; the features of organizational budgetary legal relations are revealed.
Limits of Substatutory Regulation in the Sphere of Obligatory Payments
Authors: Linev Vladimir E. ,   Postgraduate Student of the Department of Financial Law of the Kutafin Moscow State Law University (MSAL) The work is devoted
Published: July 2024

The work is devoted to the problem of distinguishing between legislative and subordinate regulation in the field of fiscal payments, which has been little studied in general theoretical and industrial aspects. The scope, limits and criteria for the admissibility of departmental law-making are determined. Particular attention is paid to the authority of the Government of the Russian Federation to extend the deadlines for collecting taxes. Based on an analysis of the practice of the Constitutional Court of the Russian Federation, a conclusion is made about the impossibility of applying the concept of delegated legislation in relation to those issues that, in accordance with the Constitution of the Russian Federation, are the exclusive prerogative of the legislator.
amor não acabou, mas os caminhos tomaram rumos diferentes
Authors: Aquino Maria Clara , De Figueiredo Souza Ana Luiza
Published: July 2024

No início de 2023, o casal Nataly Mega e Fábio Porchat anunciou no Instagram sua separação, depois de oito anos juntos. A notícia gerou comentários nas publicações feitas pelo ex-casal, além de ampla repercussão na imprensa e mídias sociais. O planejamento familiar teve destaque nessa repercussão, já que ter ou não ter filhos foi apontado como fator decisivo para que o ex-casal encerrasse o casamento. Por meio de uma análise de construção de sentidos em redes digitais, o artigo explora as disputas de sentido que emergem do debate sobre o planejamento familiar – ou planejamento da (não) parentalidade – de personalidades midiáticas construídas a partir dos comentários no post (original e compartilhado) sobre a separação de Nataly e Fábio. Identificam-se tensões e tendências entre as expectativas sociais relacionadas à maternidade, à paternidade e à vida sem filhos, principalmente entre o público feminino, o mais presente entre as manifestações. Conclui-se que o modo como o anúncio do divórcio foi feito e o fato de tantas pessoas exigirem explicações sobre os motivos que levaram ao término revela a sensação de proximidade e acesso à intimidade do ex-casal por parte do público que o acompanha. Assim, a comoção em torno de términos de personalidades midiáticas pode ser relacionada a uma lógica de consumo da intimidade que se alastra para a vida familiar dessas personalidades. Nesse contexto, as respostas sobre os projetos parentais divergentes do ex-casal reúnem concepções tradicionais, (des)apoio à (não) parentalidade planejada e a valorização das atitudes necessárias para atingir os objetivos de seus projetos de vida.
INDIVIDUAL COUNSELING SERVICES TO ADDRESS THE TRAUMA OF ADOLESCENT VICTIMS OF SEXUAL ABUSE THROUGH ISLAMIC THERAPY
Authors: YULIA SARI  , SARAGI MUHAMMAD PUTRA DINATA , SIHOMBING FIRLY SYAHIRA , INDAH SARI  , PANJAITAN PUTRI RAHMADANI
Published: July 2024

Sexual harassment is a bad act that can reduce human dignity, both women and men. The rise of the problem of sexual harassment can occur among teenagers. Victims of sexual harassment will usually experience mental wounds that can affect their mental and psychological states that take time to heal, such as experiencing trauma. The sense of trauma that exists in adolescents will make them into shock, and it needs to be handled through Islamic therapy. This study aims to overcome the trauma of adolescents who are victims of sexual harassment. This study uses a qualitative approach with data collection techniques through observation and interviews. The result of this study has shown that the application of individual counseling services by applying Islamic therapy can overcome trauma in one of the teenage boys who became victims of sexual harassment. The application of Islamic therapy has been carried out using faith therapy so that the teenager will get peace and inner peace and become a person who always increases faith or draws closer to Allah Swt. by enjoining ma'ruf nahi munkar.
GUIDANCE BASED ON SURAH AL-FATIHAH TO INCREASE THE FAITH OF CONVERTS IN DZAL HAJRA KUBU RAYA DISTRICT WEST KALIMANTAN
Authors: HIQQAL MUHAMMAD , EDI KURNANTO MUHAMMAD
Published: July 2024

This research is motivated by the low faith of converts because they have not properly practiced worship according to Islamic law. Converts to worship only limited to fulfilling their obligations as a Muslim are not internalized and practiced in everyday life. This study aims to obtain an overview of the faith of converts before and after being given guidance based on surah Al-Fatihah and to see the effectiveness of guidance based on surah Al-Fatihah in increasing converts' faith. The level of faith that often fluctuates makes converts must always try to maintain their faith so that it always increases every day. Increased faith is very influential on the consistency of worship and practice in the daily life of converts. This study uses a mixed research method (mixed method) by making two groups consisting of an experimental group and a control group. The resulting data were analyzed using the t test of the two most independent samples (independent t test). The resulting data shows that the average value of the control group is smaller than the average value of the experimental group, which means that there is an increase in the effectiveness of surah Al-Fatihah-based guidance in increasing the faith of converts. The results of the research conducted obtained a significance of 0.00 which is smaller than 0.05, so that H0 was rejected and Ha was accepted. From these results it is known that there is an increase and the effectiveness of surah Al-Fatihah-based guidance in increasing the faith of converts.
PROSOCIAL BEHAVIOR IN ISLAMIC PSYCHOLOGY
Authors: Fadlia Ilmiyati Refi , Casmini Casmini
Published: July 2024

Nowadays, there has been a decline in morality toward others. It is resulting in various problems, such as bullying, theft, promiscuity, alcohol, drugs, death due to social media violence, and anxiety. The variety of conflicts that occur means that prosocial behavior is needed to minimize the conflicts that arise. Prosocial behavior is defined as behavior that positively impacts the individual himself or others. This research aims to find out how prosocial behavior is from the perspective of Islamic psychology. This research uses a literature study type of research (literature review). This research uses books and articles relevant to the author's discussion as the primary data sources for obtaining research related to prosocial behavior. This research shows that in Islamic psychology, prosocial behavior is in the form of helping; in surah al-maida verse 2, the words birr and piety are mentioned. Where birr means all good deeds, taqwa means fear of Allah, avoiding Allah's prohibitions, and carrying out Allah's commands.
Lactancia materna y glucemia en el recién nacido en el Hospital Departamental de Huancavelica
Authors: Tapia Camargo Marisol Susana , Gabriel Santos Ida , Tito Cordova Luis Alberto , Llanco Sedano Emily Eliana
Published: July 2024

La hipoglucemia en el recién nacido responde a uno de los más serios problemas de salud pública en el mundo. Es la enfermedad metabólica más frecuente y de inicio precoz en los recién nacidos, relacionada con la asimilación de carbohidratos. Objetivo: Identificar el efecto de la lactancia materna en los niveles de glucemia durante las primeras horas de vida de los recién nacidos del servicio de neonatología en un hospital de Huancavelica, Perú. Materiales y métodos: Investigación cuasiexperimental, con 43 recién nacidos normales previa consideración de criterios de inclusión. Las enfermeras investigadoras, en su turno correspondiente, recibían al recién nacido, brindaban los cuidados a la madre y se aseguraban de que se dé una adecuada técnica de lactancia, cuidando que esta se lleve a cabo de modo exitoso durante las dos primeras horas de vida, luego de ello median la glucosa y reportaban el valor. Resultados: Se encontró euglucemia (nivel normal de glucosa en la sangre) en el 95,35 % de los recién nacidos. El mayor porcentaje de madres se clasificó como primigestas (58,14 %). El resultado de la prueba de Apgar (100 %) y el peso del recién nacido (81,40 %) resultaron normales. Conclusiones: Existe efecto positivo y significativo de la lactancia materna en los niveles de glucemia durante las primeras horas de vida de los recién nacidos del servicio de neonatología de un hospital de Huancavelica.
Manejo del catéter venoso central de inserción periférica y calidad de cuidado de enfermería en neonatos
Authors: Ramirez Julcarima Melva Nancy , Paz Soldán Oblitas Carlos Enrique , Becerra Medina Lucy Tani , Caffo Marruffo Marlene Esperanza
Published: July 2024

Objetivo: Determinar la relación entre el manejo del catéter venoso central de inserción periférica y la calidad del cuidado de enfermería en neonatos en una unidad de cuidados intensivos. Materiales y métodos: Estudio retrospectivo, correlacional, no experimental, con una población de 136 catéteres venosos centrales de inserción periférica implantados en neonatos hospitalizados en cuidados intensivos de un hospital de Lima, Perú. Se aplicaron dos fichas Ad hoc. La validez de los instrumentos se dio según la prueba V de Aiken, obteniéndose valores de 0,99 y 1,00; y la confiabilidad KR-20 fue de 0,78 y 0,81, respectivamente. Resultados: El manejo del catéter en sus dimensiones implantación, mantenimiento y retiro fue adecuado en un 87,5 %, 94,9 % y 94,1%, respectivamente. Respecto a la calidad del cuidado de enfermería en sus dimensiones cuidado continuo y cuidado seguro, se evidenció, respectivamente, que el 76,5% y el 91,2 % fueron calificados como regulares; sin embargo, en la dimensión cuidado oportuno la calidad fue regular y buena en un 44,9 % para ambas. Conclusión: El manejo del catéter venoso central de inserción periférica se relaciona significativamente con la calidad del cuidado de enfermería en neonatos en una unidad de cuidados intensivos.
Autocuidado y ansiedad en tiempos de COVID-19 en universitarios ingresantes durante el 2022
Authors: Becerra Medina Lucy Tani , Caffo Marruffo Marlene Esperanza , Ramirez Julcarima Melva Nancy , Mendoza Vitancio Macclin Katia , Pacheco Saavedra Ana Berta , Álvarez Cerna Maria del Consuelo
Published: July 2024

Objetivo: Determinar la correlación entre la capacidad de autocuidado y la ansiedad en ingresantes universitarios. Materiales y métodos: Estudio observacional cuantitativo básico de nivel correlacional transversal en una muestra de 126 ingresantes, de un total de 186, a la Facultad de Medicina de la Universidad Nacional Federico Villarreal en sus cuatro escuelas profesionales de Enfermería, Medicina, Obstetricia y Nutrición. Se les administró el Inventario de Capacidad de Autocuidado y la Escala de Ansiedad, cuya validez y confiabilidad son 0,86 y 0,92, respectivamente. Resultados: Según el análisis descriptivo, en cuanto a la capacidad de autocuidado, el nivel fue medio con 65,9 % y alto con 32,5 %; y el nivel de ansiedad prevalente fue medio con 51,6 %, seguido de un nivel bajo con 32,5 %. Conclusión: La prueba de Rho Spearman determinó que existe relación significativa y débil entre las variables autocuidado y ansiedad en los universitarios ingresantes (–0,176, con un nivel de significancia bilateral de 0,049 [<0,05]).
Ruh Sağlığı Alanında Yapay Zeka Araştırmaları: Bibliyometrik Bir Değerlendirme
Authors: Uslu Esra , Atılgan Emrah
Published: July 2024

Bu çalışmada ruh sağlığı alanındaki yapay zeka yayınlarının bibliyometrik olarak incelenmesi amaçlanmıştır. Çalışmada 1984 ile 2024 yılları arasında Web of Science veri tabanında İngilizce "mental health and artificial intelligence- ruh sağlığı ve yapay zeka" anahtar kelimeleri ile belirlenen 2773 makale incelenmiştir. Veri analizi ve grafiksel sunumlar, R yazılımındaki Bibliometrix Paketi kullanılarak yapılmıştır. Çalışmaların ortalama yayın yaşı 2,7 ve yıllık artış oranı %18,36 olarak belirlenmiştir. En aktif ülke Amerika Birleşik Devletleri ve Çin olup, en fazla yayın yapan dergi Frontiers in Psychiatry'dir. Makine öğrenimi konusu, alanın hem en sık kullanılanı hem de öncü temasıdır. Benzer şekilde, Chatbot, alanı şekillendiren temalar arasında yer almaktadır. Alzheimer Hastalığı ve bipolar bozukluk, ortaya çıkan veya kaybolan temalar (emerging or declining themes) arasındadır. Derin öğrenme, şizofreni ve demans konuları, alanı şekillendiren temaların gelişmeye devam etmekte, gelişmiş ancak izole kalmış, ortaya çıkan veya kaybolmaya başlayanların kesişim noktasında bulunmaktadır. Bu çalışma ile bibliyometrik verileriler kullanarak ruh sağlığı alanındaki YZ çalışmalarının performansı ve kapsamı analiz edilmiştir. Sonuçlar, konuya ilgi duyan bilgi teknolojileri ve ruh sağlığı profesyonellerine çalışmalarında rehberlik edebilir.
Echocardiographic cardiac views classification using whale optimization and weighted support vector machine
Authors: Bernabe Canqui Flores , Melgarejo-Bolivar Romel P. , Tumi-Figueroa Alfredo , Thirukumaran S. , Devi G. Meena , Sengan Sudhakar
Published: July 2024

Aim: A significant medical diagnostic tool for monitoring cardiovascular health and function is 2D electrocardiograms. For computerized echocardiogram (echo) analysis, recognizing how this device performs is essential. This paper primarily focuses on detecting the transducer's viewpoint in cardiac echo videos using spatiotemporal data. It distinguishes between different viewpoints by monitoring the heart's function and rate throughout the cycle of heartbeats. Computer-aided diagnosis (CAD) examination sizes are the first steps toward computerized classification of cardiac imaging tests. Since clinical analysis frequently starts with automatic classification, the current view can enhance the detection of Cardiac Vascular Disease (CVD).

Methods: This research article uses a Machine Learning (ML) algorithm called the Integrated Metaheuristic Technique (IMT), which is the Whale Optimization Algorithm with Weighted Support Vector Machine (WOA-WSVM).

Results: The parameters in the classification are optimized with the assistance of WOA, and the echo is classified using WSVM. The WOA-WSVM classifies the images effectively and achieves an accuracy of 98.4%.

Conclusion: The numerical analysis states that the WOA-WSVM technique outperforms the existing state-of-the-art algorithms.
Dimensions of Europeanisation: impact of Serbo-Russian relations on the course of the EU integration of Serbia
Authors: Stepaniuk Jakub
Published: July 2024

This paper analyses fluid dimension of Europeanisation and examines how relations between Serbia and Russia impacted the course of the EU integration of Serbia. Empirical analysis is based not only on an extensive desk but also 7 interviews with policy experts and institutional representatives conducted during fieldwork in Belgrade and Brussels. The paper addresses constructivist perspective on Serbo-Russian mythologised and instrumentalised friendship used for political purposes and relations with the EU. At the same time, it takes into consideration the geopolitical context and consequences of the war in Ukraine for Serbian foreign policy. The text examines to what extent Russia has been treated as a condition in the Serbian EU integration framework and concentrates on EU’s sanctions against Russia, alignment with EU’s foreign policy and pressure towards Serbia to impose sanctions targeting Russia.
The Importance of Landscape Design in Hospital Settings – Results of a Pilot Study in Poland
Authors: Trojanowska Monika , Matuszewska Joanna
Published: July 2024

The importance of contact with nature for human health was confirmed by numerous research. One of the sometimes neglected fields is the landscape design of hospital premises. This study focuses on the perception and preferences of prospective patients regarding the hospital site design. The methodology included anonymous survey with images and lists of adjectives. The online questionnaire was distributed using e-mails and social media from 4th May to 8th July 2024. The objective was to include all age groups. The results confirm previous studies and demonstrate the importance of landscape architecture design of hospital premises for the well-being of patients. The findings may inform the design of hospital sites.
Uncovering the Diversity and Distribution of Fungal Infections in Rwanda: Assessing Risks and Documenting Knowledge and Policy Gaps
Authors: Muvunyi Claude M. , Ngabonziza Jean Claude Semuto , Florence Masaisa , Mukagatare Isabelle , Twagirumukiza Marc , Ahmed Ayman , Siddig Emmanuel Edwar
Published: July 2024

Fungal infections (FIs) are spreading globally causing a significant public health concern. However, its documentation remains sparse in Africa, particularly in Rwanda. This literature review, aims to assess the risk and document current gaps in evidence and policy. It summarizes the published data about FIs in Rwanda, including ten reports published between 1972-and-2022. Blastomyces, Candida, Cryptococcus, Histoplasma, Microsporum, Pneumocystis, Rhinosporidium, and Trichophyton caused human infections. These infections primarily affected the brain, respiratory, urinary and reproductive organs, and they were diagnosed using culturing, histopathology, immunology, and/or microscopic techniques. Our findings provide an overview of the diversity and distribution of FIs, highlighting significant limitations in the country’s diagnostic capacity and surveillance system for FIs. Also, indicating severe gaps in evidence to inform policymaking, guide strategic planning and intervention, underscoring the urgent need to build national capacity in fungal diagnosis, surveillance, and research. Raising awareness among the public, scientific community, healthcare providers, and policymakers remains crucial. Furthermore, this report reveals the threats of FIs on public health and food insecurity in Rwanda. A Multisectoral One Health Strategy is essential in research and intervention to determine and reduce the health and safety impacts of fungal pathogens on human, animal, and the environment.
Microbiological Criteria for Ensuring the Safety of Mustard
Authors: Kotiuk Ewa , Skiba Dominika , Sawicka Barbara
Published: July 2024

Mustard, a widely used condiment, is derived from mustard seeds and partially defatted mustard flour. Varieties of mustard are primarily distinguished by the ratios of mustard seeds and spices used in their production. This study assessed the microbiological safety of mustard products from the Mustard and Ketchup Factory in Poland, produced between 2019-2021, in compliance with Polish and EU regulations. Three mustard types were analyzed: gourmet, creamy, and spicy, crafted from 'Borowska' white mustard and 'Małopolska' Sarepta mustard seeds. The preparation included powdered mustard seeds, water, sugar, and vinegar. Samples of mustards (20 g each) were tested in triplicate for Salmonella, spore-forming anaerobic bacteria, coliform bacteria, Staphylococcus aureus, mold, and yeast. Additionally, water and spices used in production were analyzed for total coliforms, Escherichia coli, Enterococcus, Salmonella, aerobic mesophilic microorganisms, anaerobic spore-forming bacteria, and mold. Results indicated that spices and water met all microbiological criteria. Mustard samples tested negative for Salmonella and anaerobic spore-forming bacteria, with coliforms, Staphylococcus aureus, mold, and yeast counts within acceptable limits, ensuring compliance with food safety and hygiene standards. This research underscores the importance of ongoing monitoring and strict microbiological standards to maintain food safety. Future studies should develop advanced microbial detection methods and implement robust quality control measures to reduce contamination risks in mustard and other food products.
Long-Term Oritavancin Therapy for Shoulder Prosthetic Joint Infection: A Case Guided by Therapeutic Drug Monitoring (TDM)
Authors: Buonomo Antonio Riccardo , Cattaneo Letizia , Viceconte Giulio , Calabria Ferdinando , Di Troia Gaia , Di Fusco Antonio , Mula Jacopo , Cozzolino Andrea , Ametrano Luigi , D'Avolio Antonio , Gentile Ivan
Published: July 2024

Oritavancin is a novel long-acting lipoglycopeptide with in vitro activity against methicillin-resistant (MR) Gram-positive pathogens and a good bactericidal activity even in presence of biofilm forming bacteria. It has been approved for acute bacterial skin and skin structure infections (ABSSSI), but recent reports have demonstrated possible off-label uses, as for prosthetic joint infections (PJI), which, in more than half of cases, are caused by MR Gram positive organisms.
We reported a case of a man in his eighties with a late shoulder PJI caused by methicillin resistant Staphyloccus epidermidis (MRSE) with contraindications for surgical replacement and few oral therapeutic options for a long term suppressive antibiotic therapy. The prosthesis was retained, and the patient received ten outpatient sequential doses of 1200 mg of oritavancin during 28 weeks, based on therapeutic drug monitoring (TDM) as a guide for correct timing of administration of each dose. During oritavancin administration, the patient achieved clinical cure, with disappearance of the pain and regaining pre-infection joint mobility, with no side effects reported and no further surgery or hospitalization needed. The treatment is ongoing as a long-lasting suppressive antimicrobial therapy. Oritavancin could represent an excellent solution for treating PJI caused by MR organism, especially in patients who need a long-term suppressive therapy.
Enhancing Knowledge-Aware Recommendation with Dual-Graph Contrastive Learning
Authors: Huang Jinchao , Xie Zhipu , Zhang Han , Yang Bin , Di Chong , Huang Runhe
Published: July 2024

Incorporating knowledge graphs as auxiliary information to enhance recommendation systems can improve the representations learning of users and items. Recommendation methods based on knowledge graph can introduce user-item interaction learning into the item graph, focusing only on learning the node vector representations within a single graph; alternatively, they can treat user-item interactions and item graphs as two separate graphs and learn from each graph individually. Learning from two graphs has natural advantages in exploring original information and interaction information, but faces two main challenges: 1) in complex graph connection scenarios, how to adequately mine the self-information of each graph, and 2) how to merge interaction information from the two graphs while ensuring that user-item interaction information predominates. Existing methods do not thoroughly explore the simultaneous mining of self-information from both graphs and effective interaction information, leading to the loss of valuable insights. Considering the success of contrastive learning in mining self-information and auxiliary information, this paper proposes a dual-graph contrastive learning recommendation method based on knowledge graphs (KGDC) to explore a more accurate representations of users and items in recommendation systems based on external knowledge graphs. In the learning process within the self-graph, KGDC has strengthened and represented the information of different connecting edges in both graphs, and extracted the existing information more fully. In interactive information learning, KGDC reinforces the interaction relationship between users and items in the external knowledge graph, realizing the leading role of the main task. We have conducted a series of experiments on three standard datasets, and the results show that the proposed method can achieve better results.
The generation of ROS by exposure to trihalomethanes promotes the IκBα/NF-kB/p65 complex dissociation in human lung fibroblast
Authors: Nájera-Martínez Minerva , Avilez-Alvarado Jhonatan , Pagadala Nataraj S , Dzul-Caamal Ricardo , Domínguez-López María Lilia , Tuszynski Jack , Vega-López Armando
Published: July 2024

Disinfection by-products to obtain drinking water, such as CH2Cl2, CHCl3, and BrCHCl2, elicit cytotoxicity and hyperproliferation in human lung fibroblasts (MRC-5). Enzymes of their biotransformation modulate these damages and can generate toxic metabolites. However, it is unknown that the response to oxidative stress is involved in cellular hyperproliferation modulated by nuclear factor-kappa B (NF-κB). Hence, MRC-5 cells were treated with these compounds to evaluate ROS, lipid peroxidation, phospho-NF-κB/p65 (Ser536) levels, CAT, SOD, and GPx activities. Further, the interactions of halomethanes and ROS with IκBα/NF-κB/p65 complex were analyzed by molecular docking. The correlation among biomarkers showed positive relationships between the prooxidant damage with the antioxidant response, particularly in cells treated with CH2Cl2, and BrCHCl2. Furthermore, negative relationships among ROS with levels of NF-κB/p65 in cells treated with CH2Cl2, and CHCl3 were detected. The estimated relative free energy of binding using thermodynamic integration with the p65 subunit of NF-κB was -3.3 kcal/mol for BrCHCl2; -3.5 kcal/mol for both CHCl3 and O2•, and -3.6 kcal/mol for H2O2. The chloride and bromide are in close contact with the IPT domain residues, particularly in the RHD region involved in DNA binding. Ser281 is located in the same domain, allowing this protein's phosphorylation. Similarly, both ROS are in contact with IPT domain into region RHD and H2O2 as side-chain oxygen with Leu280, adjacent to the phosphorylation site of p65. However, a negative correlation among ROS with phospho- NF-κB/p65 suggests ROS's steric hindrance on the C-terminal domain of NF-κB/p65 is involved in antioxidant response.
StarDICE II: calibration of an uncooled infrared thermal camera for atmospheric gray extinction characterization
Authors: Sommer Kélian , Plez Bertrand , Cohen-Tanugi Johann , Dagoret-Campagne Sylvie , Moniez Marc , Neveu Jérémy , Betoule Marc , Bongard Sébastien , Feinstein Fabrice , Le Guillou Laurent , Juramy Claire , Sepulveda Eduardo , Souverin Thierry
Published: July 2024

The StarDICE experiment strives to establish an instrumental metrology chain with a targeted accuracy of 1 mmag in griz bandpasses to meet the calibration requirements of next-generation cosmological surveys. Atmospheric transmission stands out as a significant source of systematic uncertainty. Specifically, gray extinction induces spurious variations of photometric fluxes. We propose a solution relying on an uncooled long-wave infrared thermal camera to evaluate it. This type of camera can provide real-time insights into atmospheric conditions and detect cirrus clouds. However, achieving accurate measurements with thermal imaging systems necessitates prior calibration due to the influence of temperature-induced effects, which compromise their spatial and temporal precision. Moreover, these systems cannot provide scene radiance values in physical units by default. This study introduces a new calibration process utilizing a tailored forward modeling approach. The method is applied to an uncooled FLIR Tau2 thermal camera. It incorporates sensor, housing, flat-field support, and ambient temperatures, along with raw digital response, as input data. Experimental measurements are conducted inside a climatic chamber, with the camera imaging a thermoregulated blackbody source. Results demonstrate the calibration effectiveness, achieving precise radiance measurements with a temporal pixel root-mean-square error (RMSE) of 0.09 W/m2/srand residual spatial noise of 0.03 W/m2/sr.
Estimating Evapotranspiration of Rainfed Winegrapes Combining Remote Sensing and the SIMDualKc Soil Water Balance Model
Authors: Almeida Wilk S. , Paredes Paula , Basto José , Pôças Isabel , Pacheco Carlos A. , Paço Teresa A.
Published: July 2024

Soil water balance (SWB) in woody crops is sometimes difficult to estimate with one-dimensional models because these crops do not completely cover the soil and usually have a deep root system, particularly when cropped under rainfed conditions in a Mediterranean climate. In this study, the actual crop evapotranspiration (ETc act) is estimated with the soil water balance model SIMDualKc which uses the dual-Kc approach (relating the fraction of soil cover with the crop coefficients) to improve the estimation of the water requirements of a rainfed vineyard, using data from a deep soil profile. The actual basal crop coefficient (Kcb act) obtained using the SIMDualKc model was compared with the Kcb act estimated using the A&P approach, which is a simplified approach based on measurements of the fraction of ground cover and crop height. Spectral vegetation indices derived from Landsat-5 satellite data were used to determine the fraction of ground cover (fc VI) and thus, the density coefficient (Kd). The SIMDualKc model was calibrated using soil water content (SWC) measurements down to a depth of 1.85 meters, which significantly improved the conditions for using a SWB estimation model. The test of the model was performed using a different SWC dataset. A good agreement between simulated and field measured SWC was observed for both data sets along the crop season, with RMSE<12.0 mm, NRMSE <13%. The calibrated Kcb values were 0.15, 0.60 and 0.52 for the initial, mid-season, and end season, respectively. The ratio between actual (ETc act) and crop evapotranspiration (ETc) was quite low between veraison and maturity (mid-season), corresponding to 36%, indicating that the rainfall was not sufficient to satisfy the vineyards water requirements. Spectral vegetation indices used to compute fc VI were unable to fully track the plants’ conditions when water stress. However, ingestion of data from remote sensing showed promising results that could be used to support decisions making in irrigation scheduling. Further studies on the use of the A&P approach using remote sensing data are required.
A follow up on the continuum theory of eco-anxiety: Analysis of the Climate Change Anxiety Scale using Item Response Theory
Authors: Hannachi Taha , Yakimova Sonya , Somat Alain
Published: July 2024

The mental health impact of the environmental crisis, particularly eco-anxiety, is a growing research topic whose measurement still lacks consensus. In this article, we use item response theory (IRT) to better un-derstand what existing questionnaires measure. To conduct this review, we used open-access data from the short French version of the Climate Change Anxiety Questionnaire (Mouguiama-Daouda et al. 2022, Heeren et al., 2023). Our results suggest that, of the different models tested, the unidimensional model seems to be the most appropriate for measuring eco-anxiety. The item difficulty parameter extracted from the IRT enabled us to discuss the level of severity of the items making up this tool. The Climate Change Anxiety Questionnaire is more appropriate for measuring severe to moderately severe eco-anxiety. Ave-nues for improving this questionnaire and the measurement of eco-anxiety in general are then discussed.
Sustainable Technologies for Ecological Societies Directed to Energy Transition
Authors: Coccia Mario
Published: July 2024

Ecological Society is based on socioeconomic systems directed to the equilibrium of inter-relationships between environment, climate, production systems, technologies and human communities to promote the overall well-being of people and the Earth planet. It has a main goal for supporting sustainable development and equitable societies and achieving optimal health outcomes recognizing the interconnection between people, technologies, animals, plants, and their shared environment for the one health. Using data of scientific publications and patents until the year 2024, this study shows new technologies that can support the energy transition with the shift from fossil fuels to renewable energy sources in an effort to reduce CO2 emissions for an ecological society having, whenever possible, zero-carbon economies to reduce environmental pollution and climate change and foster health and wellbeing of people. Results reveal that sustainable technologies supporting the transformation of the energy sector, economies and societies, and having a rapid growth, are blue hydrogen, floating photovoltaic systems, carbon capture and utilization, green hydrogen and liquid metal batteries. These findings can guide decisions of policymakers and stakeholders towards fruitful investments driving the transition from fossil-based to zero-carbon socioeconomic systems to have a long-run sustainable development of overall world system that has to direct towards an ecological society associated with one health.
Potential Regulation of Iron Metabolism Gene Expression by DOF Transcription Factors in Dendrocalamus latiflorus
Authors: Zhu Peng-Kai , Lin Mei-Xia , Zeng Mei-Yin , Tang Yu , Li Xin-Rui , He Tian-You , Zheng Yu-Shan , Chen Ling-Yan
Published: July 2024

Abstract: Transcription factors are crucial pre-transcriptional regulatory mechanisms that can modulate the expression of downstream genes by binding to their promoter regions. DOF (DNA binding with One Finger) proteins are a unique class of transcription factors with extensive roles in plant growth and development. Our previous research indicated a decrease in iron content in chlorotic bamboo leaves. However, to our knowledge, genes related to iron metabolism pathways in bamboo species have not yet been studied. Therefore, in the current study, we identified iron metabolism-related (IMR) genes in bamboo and determined the transcription factors that significantly influence them. Among these, DOFs were found to have widespread effects and potentially significant impacts on their expression. We identified specific DOF members in Dendrocalamus latiflorus with binding abilities through homology with Arabidopsis DOF proteins, and established connections between some of these members and IMR genes using RNA-seq data. Additionally, molecular docking confirmed the binding interactions between these DlDOFs and the DOF binding sites in the promoter regions of IMR genes. The co-expression relationship between the two gene sets was further validated using q-PCR experiments. This study paves the way for research into iron metabolism pathways in bamboo and lays the foundation for understanding the role of DOF transcription factors in D. latiflorus.
Beyond the Label: Exploring Consumer Perceptions and Practices of Complementary and Alternative Medicines in Melbourne, Australia
Authors: Naseri Kaveh , Shahin Wejdan , Allahham Ayman , Nooney Vivek , de Courten Barbora , Thrimawithana Thilini R.
Published: July 2024

Background: Complementary and alternative medicines (CAM) are widely used, with pharmacies accounting for a significant share of the distribution market. Despite their popularity, many CAMs lack scientific evidence for effectiveness, and some can cause adverse health effects. Limited research exists on CAM-related adverse events and the effectiveness of CAM labels in conveying crucial information. Methods: This cross-sectional study aimed to investigate CAM utilization, consumer perspectives, and the influence of labels on CAM usage in Melbourne, Australia. Data were collected through an online questionnaire and analysed using descriptive statistics, Pearson's correlation, MANOVA, and regression analyses. Results: The study enrolled 125 current CAM users, primarily recruited from pharmacy and supermarket customers (age: predominantly 31-50; gender: 20.8% male, 79.2% female). Participants' perceptions of effectiveness and safety were positively correlated. Label warnings prompted information-seeking, but consultation with healthcare professionals (HCPs), particularly pharmacists, was infrequent (24%). Adverse reactions were reported by 18.5% of participants, with 8.3% experiencing severe reactions. The analysis revealed relationships between CAM usage and demographics. Ordinal logistic regression showed a significant association between calcium consumption and higher age groups (coefficient = 1.658, p = 0.006), while binary logistic regression identified higher iron consumption among females (coefficient = 2.177, p = 0.007). Conclusions: Label warnings significantly prompted consumers to seek more information about CAMs. However, a limited engagement of HCPs, especially pharmacists, suggests an opportunity for improved consumer education and pharmacist involvement in CAMs-related discussions. The findings highlight demographic influences on CAM usage being essential for developing targeted health interventions and policies. Addressing these aspects may lead to safer CAM practices and informed consumer decision-making.
Evaluation of Population Pharmacokinetic Models of Micafungin: Implications for Dosing Regimen Optimization in Critically Ill Patients
Authors: Li Xiping , Liu Xiaoqin , Mao Juehui , Liu Dong , Jiao Zheng
Published: July 2024

Not occasional phamracokinetic variability and suboptimal exposure have been reported for micafungin in the intensive-care-unit (ICU) patients. This study aims to evaluate the quality of population pharmacokinetic models and provide rational using recommendation of this drug in clinical practice. Monte Carlo simulations were implemented to compare pharmakinetic parameters and probability of target attainment (PTA) towards various Candida species. Body weight, liver function, and SOFA score were the most frequent covariates in the final 16 included studies. micafungin clearance for ICU adults (SOFA≥10 or <10) was 39%–52% and 43%–57% higher, respectively, than non-ICU adults. For Candida infections with MICs <0.016 mg/L, the ICU group had lower proportions achieving PTA > 90% compared to the non-ICU group (2/6 (33%) vs. 4/7 (57%)), and for non-ICU and ICU adults, micafungin dosages of 100 and 150 mg were recommended, respectively. While for C. tropicalis and C. glabrata, 200 and 250 mg were recommended respectively. However, for C. krusei and C. parapsilosis, it failed to reach assumed PTA at MICs of 0.125-0.25 mg/L and 0.125-2 mg/L, respectively. Adjusting micafungin dosage in ICU patients may be necessary. Both ICU and non-ICU adults should modify their dosage regimens based on the Candida species and their respective MICs.
Exploring Transparency and Accountability in Supplier Relationship Management for E-Commerce
Authors: Grant Oliver
Published: July 2024

This study explores the dynamics of transparency and accountability in supplier relationship management (SRM) within the e-commerce sector. It investigates how e-commerce platforms and their suppliers navigate complexities to foster trust, enhance collaboration, and ensure ethical practices in global supply chains. The research employs a qualitative approach, utilizing semi-structured interviews with industry stakeholders to gather insights into current practices, challenges, and strategies in SRM. Findings highlight transparency as pivotal for sharing critical information such as sales forecasts, inventory levels, and pricing strategies, enabling suppliers to align operations with market demands effectively. However, achieving transparency faces hurdles including data privacy concerns and competitive sensitivities, necessitating robust data security measures and clear communication protocols. Accountability mechanisms, such as formal agreements and governance frameworks, emerge as essential for mitigating risks, resolving disputes, and ensuring compliance with ethical and regulatory standards across diverse contexts. Technological innovations like AI, blockchain, and big data analytics are transforming SRM by enhancing supply chain visibility, operational efficiency, and decision-making capabilities. Cultural factors and regulatory compliance also significantly influence SRM practices, shaping communication styles, relationship dynamics, and legal considerations. Emerging trends such as sustainable sourcing practices and collaborative partnerships are reshaping SRM, emphasizing sustainability and responsible business practices. This study contributes to the understanding of effective SRM strategies, offering insights and recommendations for stakeholders navigating the complexities of e-commerce supply chains.