bluuebunny/crossref_metadata_2025 huggingface dataset:
Myocardial Oedema as a Consequence of Viral Infection and Persistence—A Narrative Review with Focus on COVID-19 and Post COVID Sequelae
Authors: Panagiotides Noel G. , Poledniczek Michael , Andreas Martin , Hülsmann Martin , Kocher Alfred A. , Kopp Christoph W. , Piechota-Polanczyk Aleksandra , Weidenhammer Annika , Pavo Noemi , Wadowski Patricia P.
Published: January 2024

Microvascular integrity is a critical factor in myocardial fluid homeostasis. The subtle equilibrium between capillary filtration and lymphatic fluid removal is disturbed during pathological processes leading to inflammation, but also in hypoxia or due to alterations in vascular perfusion and coagulability. The degradation of the glycocalyx as the main component of the endothelial filtration barrier as well as pericyte disintegration results in the accumulation of interstitial and intracellular water. Moreover, lymphatic dysfunction evokes an increase in metabolic waste products, cytokines and inflammatory cells in the interstitial space contributing to myocardial oedema formation. This leads to myocardial stiffness and impaired contractility, eventually resulting in cardiomyocyte apoptosis, myocardial remodelling and fibrosis. The following article reviews pathophysiological inflammatory processes leading to myocardial oedema including myocarditis, ischaemia-reperfusion injury and viral infections with a special focus on the pathomechanisms evoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In addition, clinical implications including potential long-term effects due to viral persistence (long COVID), as well as treatment options, are discussed.
A New Open Channel Flow Correction Method Based on Different Boundary Combinations in Hydraulic Modeling
Authors: Chen Mingrui , Wei Wentao , Zhang Zhao , Xue Linan , Kong Lingzhong , Li Haichen , Liu Yuxin , Liu Hairuo
Published: January 2024

In open-channel water transfer projects, hydrodynamic modeling has been one of the tools commonly used by the scheduling staff to perceive the changes in the water condition of the channel. The reliability of the flow monitoring data has not been guaranteed due to restrictions in the flow monitoring method. Flow monitoring errors directly reduce the accuracy of hydrodynamic modeling calculations, making it impossible to accurately grasp the real-time changes in the internal water conditions of the channel. In this paper, by utilizing the characteristics of the hydrodynamic model itself, which can be solved discretely with multiple boundary conditions, the method of correcting the boundary anomaly data is proposed by changing the combination of hydrodynamic boundaries. This solves the problem of the inaccuracy of hydrodynamic model calculations due to errors in the monitoring data and improves the accuracy of the hydrodynamic model calculations. In the actual operation process, it is found that the method proposed in this paper solves the problem of hydrodynamic model misalignment caused by flow observation errors by correcting the flow during the flow adjustment period, which greatly improves the calculation accuracy of the hydrodynamic model. Secondly, for a stable flow period, the method proposed in this paper can quickly capture and correct the local monitoring of abnormal data and improve the overall hydrodynamic simulation accuracy.
A Scientometric Review for Uncertainties in Integrated Simulation–Optimization Modeling System
Authors: Li Congcong , He Lulu , Liu Dan , Feng Zhiyong
Published: January 2024

Water resources management is a challenging task caused by huge uncertainties and complexities in hydrological processes and human activities. Over the last three decades, various scholars have carried out the study on hydrological simulation under complex conditions and quantitatively characterized the associated uncertainties for water resources systems. To keep abreast of the development of the collective knowledge in this field, a scientometric review and metasynthesis of the existing uncertainty analysis research for supporting hydrological modeling and water resources management has been conducted. A total of 2020 publications from 1991 to 2018 were acquired from the Web of Science. The scientific structure, cooperation, and frontiers of the related domain were explored using the science mapping software CiteSpace V5.4.R3. Through co–citation, collaboration, and co–occurrence network study, the results present the leading contributors among all countries and hotspots in the research domain. In addition, synthetical uncertainty management for hydrological models and water resource systems under climatic and land use change will continue to be focused on. This study comprehensively evaluates various aspects of uncertainty analysis in hydrologic simulation–optimization systems, showcasing advanced data analysis and artificial intelligence technologies. It focuses on current research frontiers, aiding decision–makers in better understanding and managing the complexity and uncertainties of water resource systems, thereby enhancing the sustainability and efficiency of responses to environmental changes.
Variation and Transformation of Evapotranspiration at Different Scales in a Desert Steppe
Authors: Tang Pengcheng , Guo Jianying , Gao Xiaoyu , Zheng Ying , Wang Bo , Hao Lei , Wang Jiashuang
Published: January 2024

Water resources are severely scarce in desert steppes, and precipitation rarely collects in rivers or is transformed into groundwater. Evapotranspiration (ET) is the primary “export” of precipitation conversion and is the main mechanism for water vapor exchange between the underlying surface and atmosphere. ET changes have certain scale effects. This study focused on the natural grasslands in the Xilamuren Desert Steppe and analyzed and estimated the ET patterns at different scales, including micro-, point-, and surface scales, using observational data from instruments such as a photosynthetic meter, Eddy-covariance system (EC), and large-aperture scintillometer (LAS) from the Ecological Hydrology National Field Science Observation Station in the northern foothills of the Yin Mountains, Inner Mongolia. The spatial scale was extended based on this analysis. The results showed that at the microscale, the diurnal variation in the photosynthetic and transpiration rates of Leymus chinensis followed a bimodal curve. In July and August (high-temperature months), photosynthetic and transpiration rates were almost synchronous. In May and October, when the temperature was moderate, the transpiration rate was delayed compared to the photosynthetic rate at the first peak, and the second peak was significantly smaller than the first peak. At the point-scale, the daily average ET during the growing season was 1.37 mm·d−1 and the total cumulative ET was 251 mm. Transpiration levels exhibited significant seasonal variation in the following order: July > August > June > September > May > October. At the surface-scale, the daily average ET during the growing season was 1.60 mm·d−1 and the total cumulative ET was 294 mm, which was 17% higher than that of the point-scale. The surface-scale ET was estimated using the observed values of the EC and the scale relationship formula and was optimized using different spatial scales of crop coefficients. This well reflected the ET patterns at the surface-scale. Therefore, this study proposes a spatial scale expansion method for a homogeneous underlying surface, verifies its value, and provides methodological support for estimating ET in cases of data scarcity.
Geochemical Characteristics and Controlling Factors of Groundwater Chemical Composition in the Zihe River Source Area, Shandong, China
Authors: You Jing , Qi Yueming , Shao Guangyu , Ma Chao
Published: January 2024

The geochemical characterization and evolution of shallow groundwater in the Zihe River source area is a key issue that needs to be addressed. In this study, a combination of traditional geochemical techniques and geochemical modeling was used to explain the geochemical processes and major ion sources in the chemical evolution of shallow groundwater in the Zihe River source area, Northeast China. Fifty-seven water samples were collected in June 2020 for chemical analysis, and the results showed that the main groundwater chemistry types in the three major aquifers are HCO3·SO4-Ca·Mg-type pore water from loose quaternary rocks, HCO3·SO4-Ca·Mg-type karstic fissure water from carbonate rocks, and HCO3·SO4-Ca-type weathered fissure water from massive rocks. Water–rock interactions in alkaline environments were the main causes of changes in groundwater chemistry. Rock weathering dominated the geochemical evolution of each aquifer. The analysis of ion concentration ratios and modeling revealed that the aquifer’s chemical components are mainly derived from the dissolution of dolomite and calcite and partly from the infiltration of pollutants containing Cl− and NO3−, as well as from the dissolution of quartz. Mg2+ is derived from the dissolution of dolomite. HCO3− is primarily derived from the co-dissolution of calcite and dolomite, and to a lesser extent, its content is also influenced by the recharge of rainfall. SO42− has two sources: it mainly originates from the dissolution of gypsum and the anhydrite layer, followed by atmospheric precipitation. The synthesis showed that the groundwater quality in the source area of Zihe River is good, all the indices reached the standard of class III groundwater quality, and the overall degree of human pollution is low. The results of this research will provide a scientific basis for the local authorities to delineate karst groundwater protection zones in the Zihe River source area and to formulate resource management strategies for the development, utilization, and protection of karst groundwater.
Short-Term Observations of Rainfall Chemistry Composition in Bellsund (SW Spitsbergen, Svalbard)
Authors: Lehmann-Konera Sara , Ruman Marek , Frankowski Marcin , Małarzewski Łukasz , Raczyński Krzysztof , Pawlak Filip , Jóźwik Joanna , Potapowicz Joanna , Polkowska Żaneta
Published: January 2024

Global warming results in increasingly widespread wildfires, mostly in Siberia, but also in North America and Europe, which are responsible for the uncontrollable emission of pollutants, also to the High Arctic region. This study examines 11 samples of rainfall collected in August in a coastal area of southern Bellsund (Svalbard, Norway). It covers detailed analysis of major ions (i.e., Cl−, NO3−, and SO42−) and elements (i.e., Cu, Fe, Mn, Pb, and Zn) to Hybrid Single-Particle Langrarian Integrated Trajectory( HYSPLIT) backward air mass trajectories. The research of wildfires, volcanic activities, and dust storms in the Northern Hemisphere has permitted the assessment of their relations to the fluctuations and origins of elements. We distinguished at least 2 days (27 and 28 August) with evident influence of volcanic activity in the Aleutian and Kuril–Kamchatka trenches. Volcanic activity was also observed in the case of the Siberian wildfires, as confirmed by air mass trajectories. Based on the presence of non-sea K (nsK), non-sea sulphates (nss), and Ca (the soil factor of burned areas), the continuous influence of wildfires on rainfall chemistry was also found. Moreover, dust storms in Eurasia were mainly responsible for the transport of Zn, Pb, and Cd to Svalbard. Global warming may lead to the increased deposition of mixed-origin pollutants in the summer season in the Arctic.
Vehicle Trajectory Prediction Based on Local Dynamic Graph Spatiotemporal–Long Short-Term Memory Model
Authors: Chen Juan , Feng Qinxuan , Fan Daiqian
Published: January 2024

Traffic congestion and frequent traffic accidents have become the main problems affecting urban traffic. The effective location prediction of vehicle trajectory can help alleviate traffic congestion, reduce the occurrence of traffic accidents, and optimize the urban traffic system. Vehicle trajectory is closely related to the surrounding Point of Interest (POI). POI can be considered as the spatial feature and can be fused with trajectory points to improve prediction accuracy. A Local Dynamic Graph Spatiotemporal–Long Short-Term Memory (LDGST-LSTM) was proposed in this paper to extract and fuse the POI knowledge and realize next location prediction. POI semantic information was learned by constructing the traffic knowledge graph, and spatial and temporal features were extracted by combining the Graph Attention Network (GAT) and temporal attention mechanism. The effectiveness of LDGST-LSTM was verified on two datasets, including Chengdu taxi trajectory data in August 2014 and October 2018. The accuracy and robustness of the proposed model were significantly improved compared with the benchmark models. The effects of major components in the proposed model were also evaluated through an ablation experiment. Moreover, the weights of POI that influence location prediction were visualized to improve the interpretability of the proposed model.
Codification of legislation in the field of social security in the EAEU countries and Russia
Authors:   Department of International Law The Diplomatic Academy of the Russian Foreign Ministry, Gusev A.Yu. , Batusova E.S. ,   Department of Public Law, Faculty of Law, National Research University Higher School of Economics
Published: January 2024

There are two main models of legal regulation of social protection in Russia and the EAEU countries. In Russia, Armenia and Azerbaijan, social legislation is not codified. While in Kazakhstan and Turkmenistan, the social Code and the Code of protection of the population have been adopted and are functioning, respectively. It can be argued that there is a tendency aimed at systematization of social legislation. This makes it possible to solve most of the problems in the field of legal regulation of social protection, including in the field of activity of the employer’s personnel services. To optimize legal regulation, it is necessary to develop a Social Code, where, among other things, all types of social security will be systematized and the legal status of the employer in this area will be clearly defined.Employers can already build a personnel policy aimed at reducing social risks.
EXPERIMENTAL RESEARCH ON INCREASING THE ABRASIVE WEAR RESISTANCE OF DISINTEGRATOR IMPACT ELEMENTS
Authors: Kachaev A. , Chemerichko G. , Sevost'yanov V.
Published: January 2024

A method for assessing the wear resistance of round impact elements of a disintegrator is considered using the example of grinding highly abrasive mica-crystalline materials (expanded vermiculite and its concentrate) in a disintegrator. A constructive method for protecting the working surfaces of impact elements from abrasive wear when dispersing similar materials in a disintegrator of a developed design is presented. Using mathematical expressions to estimate the wear parameters of the impact elements of the mill, experimental values of the wear of the impact elements were obtained depending on the linear speed of the impact element, the reduced productivity of the disintegrator, the weighted average size of the crushed particles, the strength of the crushed raw materials and the hardness of the material from which the impact elements are made. The differentiated influence of variable factors on the process of abrasive wear of the surfaces of the impact elements of the disintegrator has been determined. Using a graphical interpretation of the results of experimental studies of the process of abrasive wear of the impact elements of the disintegrator, it was established that the wear of the impact elements mainly depends on the productivity of the unit (mill throughput). As the productivity of the disintegrator increases, the specific wear of the working elements decreases due to a decrease in the flow density of the moving material inside the mill, regardless of its high absolute speed inside the grinding chamber. In order to reduce the surface abrasive wear of the impact elements of the disintegrator, the effectiveness of using special protective bushings made of baddeleyite-corundum materials, resistant to abrasive wear by silicate mica-crystalline rocks, was proposed and experimentally confirmed. A comparison was made of the proposed design solution for protecting the working surfaces of impact elements with previously used impact elements made of grade 45 steel hardened to HRC 50.
Mapeamento e melhoria dos processos de gestão da pesquisa acadêmica: estudo descritivo narrativo
Authors: Faria Tamara Veiga , Scandiuzzi Silvio de Melo , Machado Henrique Tofoli Vieira , De Oliveira Amanda Fidelis , Leandro Cássio Berti , Farias Tayse Silva , Pacca Felipe Colombelli , De Castro Rogério Cardoso , Valentino Talita Caroline de Oliveira
Published: January 2024

Introdução: A pesquisa acadêmica visa aumentar a produção e qualificação profissional, estimulando o raciocínio crítico. Fundamental para docentes e discentes, proporciona acesso a conteúdo atualizados e incentiva a produção de conhecimento. O estudo destaca o SIPOC como ferramenta estratégica na gestão acadêmica, visando não apenas ampliar a quantidade, mas elevar a relevância e o impacto dos resultados científicos na faculdade de medicina, promovendo eficiência na estruturação de pesquisas. Objetivos: Mapear e melhorar os processos de gestão da pesquisa acadêmica de uma faculdade de medicina do interior paulista. Desenvolver a matriz SIPOC para o processo e iniciação científica e produção científica de docentes e discentes. Materiais e Métodos: Estudo descritivo narrativo do mapeamento e melhoria dos processos de gestão da pesquisa acadêmica através da matriz SIPOC em Faculdade de medicina do interior paulista. Relato de Experiência: O Departamento de Pesquisas implementou o diagnóstico organizacional usando a ferramenta SIPOC para mapear e padronizar processos. Identificou lacunas e antecipou a expansão, atendendo à crescente demanda acadêmica. A coordenação priorizou atividades, destacando a relação com a disciplina de habilidades de pesquisa. O SIPOC foi crucial na organização sequencial das demandas. O processo de pesquisa, do edital à publicação do artigo, foi modelado, com metas definidas para fortalecer a produção científica. A seleção de professores e alunos, elaboração de editais e protocolos, coleta de dados e acompanhamento, culminam na publicação do artigo científico, envolvendo estatísticos e pesquisadores do departamento. Considerações Finais: A aplicação da matriz SIPOC no contexto acadêmico otimiza os processos de produção científica em instituições de ensino superior, promovendo excelência e disseminação do conhecimento na área médica. Favorece aumento da produção, raciocínio crítico, acesso a pesquisa avançada e incentiva o desenvolvimento científico.
Vigilância da pessoa sob intubação endotraqueal: outcomes da intervenção de enfermagem na monitorização da pressão do cuff – revisão integrativa da literatura
Authors: Ribeiro Juliana Santos , Ramos Filipe Alexandre Morgado
Published: January 2024

Introdução: A permeabilização da via aérea constitui o primeiro passo na abordagem à pessoa em situação crítica, sendo o tubo endotraqueal o dispositivo mais seguro para a sua manutenção. No entanto, a pressão do cuff constitui uma das complicações associadas a esta via aérea definitiva, exigindo dos enfermeiros uma vigilância, com vista à prevenção e reconhecimento céleres de alterações na pessoa cuidada, intervindo precocemente para a promoção da segurança da mesma. Objetivos: Reconhecer os outcomes da intervenção de enfermagem na monitorização da pressão do cuff no cuidado à pessoa sob intubação endotraqueal e identificar a existência de protocolos orientadores da monitorização da pressão do cuff nos contextos clínicos. Questão de Investigação: “Quais os outcomes da monitorização da pressão do cuff no cuidado à pessoa sob intubação endotraqueal em situação crítica?”. Metodologia: Revisão Integrativa da Literatura desenvolvida segundo as recomendações do Joanna Briggs Institute. A pesquisa de artigos foi realizada na plataforma de pesquisa EBSCOhost, nas bases de dados MEDLINE Complete e CINAHL Complete, entre agosto e setembro de 2022. Resultados: Identificaram-se 31 artigos, selecionando-se nove que evidenciam os outcomes da intervenção de enfermagem na monitorização da pressão do cuff, na vigilância da pessoa sob intubação endotraqueal. Considerações Finais: A vigilância de enfermagem na pessoa sob intubação endotraqueal potencia a promoção da segurança dos cuidados, diminuindo o risco de morbilidade, mortalidade e os custos em saúde. No entanto, é necessário um maior investimento na produção de conhecimento científico acerca da monitorização da pressão do cuff, com o desenvolvimento de protocolos orientadores da sua implementação nos contextos clínicos.
Impacto de las costumbres alimentarias en Nuevo León, México: estudio parcial
Authors: Rodríguez Karyme Benavides , Mar Karem Hernández , Santiago Regina Ramos , Saenz Mayra Yeverino , Alvarado Natalia Campos , Rosas Ana Victoria Rubio
Published: January 2024

En los últimos años, ha aumentado la prevalencia de enfermedades crónico-degenerativas en el mundo, incluyendo México, debido a sus costumbres alimenticias. Nuevo León ha experimentado un incremento alarmante en la región, afectando a un porcentaje significativo de la población adulta. Según la ENSANUT 2022, la prevalencia de obesidad y diabetes en adultos fue del 160.0%. Además, el 46% de los adultos en México tienen niveles altos de colesterol LDL en sangre, siendo una de las principales causas de enfermedades cardiovasculares. Asimismo, 3 de cada 10 niños y niñas entre 5 y 11 años y 7 de cada 10 adultos padecen sobrepeso u obesidad. El objetivo del estudio fue analizar las costumbres alimentarias de Nuevo León, con el fin de comprender las posibles causas de enfermedades crónicas. Para ello, se realizó una encuesta a 78 voluntarios para analizar factores de predisposición. Los resultados mostraron que las personas de 40 a 49 años son las que padecen más obesidad, diabetes y enfermedades gastrointestinales. De acuerdo con lo anterior, las costumbres alimentarias de una población influyen significativamente en el riesgo de padecer enfermedades crónicas, lo que destaca la importancia de promover una alimentación saludable para reducir el impacto de estas enfermedades en la salud.
Análise do desempenho dos centros de especialidades odontológicas da regional de saúde metropolitana I do estado do Pará em 2022
Authors: Sousa Edilson William Natividade , Tsunemitsu Nayara Akemi , Pagliarini Jorge Luis , Tenorio Samilly Leal , Carvalho Érika de Nazaré Sales de Miranda , Carnaúba Libia Daniella Castro , Da Costa Neto Ivaniro Rodrigues , De Araújo Rodolfo José Gomes
Published: January 2024

Os Centros de Especialidades Odontológicas (CEO) são unidades que oferecem serviços odontológicos especializados aos usuários do SUS. A Portaria GM nº 1464/2011 estabelece um número mínimo de procedimentos na atenção básica, cirurgia oral, endodontia e periodontia. Avaliar o desempenho dos Centros de Especialidades Odontológicas da Regional de Saúde Metropolitana I nas áreas de cirurgia oral, endodontia e periodontia. Foi realizado um estudo avaliativo com dados do Sistema de Informação Ambulatorial do Sistema Único de Saúde (SIA/SUS) sobre os procedimentos odontológicos nos CEO da Regional de Saúde Metropolitana I do Estado do Pará, no ano de 2022. Utilizando filtros de busca: município, região de saúde, período, procedimento, complexidade (média complexidade) e quantidade apresentada, os dados foram coletados por meio do software TabNet Win32 3.0 e analisados no Microsoft Office Excel 2019, e evidenciados por meio do índice global de metas. Tendo como base o ano de 2022, os municípios de Belém, Ananindeua, Marituba e Benevides alcançaram um desempenho considerado “ótimo” em relação ao cumprimento global de metas, com exceção da especialidade de endodontia do Centro de Especialidades Odontológicas do município de Marituba que teve um desempenho classificado como “bom”. O presente estudo evidencia a importância do monitoramento do desempenho dos Centros de Especialidades Odontológicas da Região de Saúde Metropolitana I, dessa forma, a avaliação do cumprimento de metas é indispensável para os planejamentos e intervenção em saúde bucal na média complexidade.
O uso de Cannabis no tratamento do Transtorno do Espectro do Autismo – revisão sistemática
Authors: Engler Gabriela Pederiva , Da Silva Gabriela Almeida Fontes , Torres Thiago Macedo , Priscilla Débora , Lopez Alberto Grover Prado , Da Silva Maria da Conceição Silva , Morais Mauro José de Deus , Leitão Francisco Naildo Cardoso
Published: January 2024

O Transtorno do Espectro do Autismo (TEA) é uma condição complexa com déficits na comunicação social e comportamentos repetitivos. Não há tratamento específico, e as intervenções focam na redução de comportamentos perturbadores. O tratamento é multidisciplinar, e medicamentos, incluindo o canabidiol, são explorados como opções. Esta revisão busca analisar o uso de cannabis no TEA, dado o crescente interesse em terapias alternativas. Compreender o papel da cannabis pode melhorar a gestão dos sintomas e o desenvolvimento dos pacientes, fornecendo aos profissionais de saúde e cuidadores, informações embasadas em evidências, impactando positivamente aqueles com TEA. Avaliar a influência do uso de canabinóides na manifestação dos sintomas do Autismo durante o período de 2017 a 2023. Trata-se de revisão sistemática sem metanálise elaborada conforme as recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A partir de artigos selecionados nas mais robustas e confiáveis bases de literatura, a saber: National Library of Medicine (Pubmed), Biblioteca Virtual em Saúde (BVS), Web of Science e Lilacs por descritores obtidas pelos Descritores em Ciências da Saúde (DeCS) da BVS. Foi realizada busca pelos descritores: Autism Spectrum Disorder AND Cannabis AND Cannabinoids, utilizando os critérios: (1) estudos que envolveram pacientes com TEA e uso de cannabis; (2) estudos que tiveram como objeto de estudo do impacto do uso cannabis no TEA; (3) artigos que estudaram a influência positiva e negativa, e; (4) artigos publicados nos últimos 7 anos. Submetida para registro no PROSPERO no dia 21 de outubro de 2023 com número ID 474738. Dos 129 artigos encontrados, 20 completaram os critérios rigorosos de inclusão. Vários estudos sugerem o potencial terapêutico do canabidiol no TEA, com resultados promissores, incluindo melhorias em sintomas e comportamentos. No entanto, são necessárias mais pesquisas e estudos clínicos controlados para compreender completamente os benefícios, dosagens ideais e riscos associados. Existe evidências de que o canabidiol (CBD) possa reduzir os sintomas do Transtorno do Espectro do Autismo (TEA), é importante destacar que a segurança e eficácia desse tratamento estão atualmente em estudo. A heterogeneidade dos resultados em pesquisas sugere a necessidade de estudos mais abrangentes e de longo prazo. Portanto, embora o uso de cannabis possa ter um impacto positivo na qualidade de vida das pessoas com TEA, atenuando os sintomas e melhorando a funcionalidade diária, a supervisão de profissionais de saúde é fundamental, levando em conta as necessidades individuais de cada paciente.
Brexit: analysis of the socio-economic impact on the future of UK-Ireland relations
Authors: Aquino Mateus Lopes , Ríos-Blanco Adrián , García José Manuel Carnota , Ferreiro Eladio Jardón
Published: January 2024

This paper discusses the outcomes of the debate over the status of the Irish border during negotiations for the United Kingdom’s withdrawal from the European Union (“Brexit”), aiming to measure its socioeconomic impact after the creation of a new external border. To this end, we collect and compare data on the trade of goods and services between the UK and the Republic of Ireland, foreign direct investment (FDI), gross domestic product growth, and unemployment rates for the 2016-2019 period, during which London and Brussels negotiated the Withdrawal Agreement. Special attention is given to the North-South interaction in the island of Ireland since its border was one of the most problematic issues when the new UK-EU trade deal was being crafted. Although the exact long-term implications were not completely clear in the chosen period for this analysis, the evidence found suggests that the FDI in the UK is the most negatively impacted indicator, due to the relevance of the presence of EU investors in the country before Brexit, while other variables have shown nearly no relevant fluctuations to support the hypothesis that a change on the Irish border’s status would negatively impact on the UK-Ireland economic relations on the long term.
Effects of Methanolic Extract of Aloe vera on C-Reactive Protein and White Blood Cell Count of Wistar Rats With Inflammation
Authors: Anyiam Arinze Favour , Irondi Emmanuel Anyachukwu , Obi Ejeatuluchukwu , Arinze-Anyiam Onyinye Cecilia , Omosigho Pius Omoruyi , Muhibi Musa Abidemi , Ilesanmi Ayodele Olusola , Oluwatimilehin Okelola Odunayo , Okezie Blessing
Published: January 2024

Background: It has been known for centuries that plants and plant-derived chemicals are useful in treating diseases, with Aloe vera being one of the biologically active plants. A significant role is played by the C-reactive protein (CRP) in many inflammatory conditions, while leukocytes play an integral role in the response of the immune system to infectious diseases. Objectives: This study explored the potential anti-inflammatory effects of Aloe vera methanolic extract on the total white blood cell (TWBC) count and CRP levels in Wistar rats received formalin. Methods: A total of 25 Wistar rats were divided into five groups (A to E), with group A serving as the control and the other groups receiving formalin to induce inflammation, followed by increasing doses of Aloe vera extract. The CRP level was measured using an enzyme-linked immunosorbent assay (ELISA) kit, and the TWBC count was determined using a Sysmex haematology autoanalyzer. Results: Research findings showed that 200 mg of Aloe vera methanolic extract effectively reduced the CRP level (0.056±0.0027) (P=0.04), while 600 mg of the extract significantly increased the TWBC count (13.920±4.757) (P=0.03). Conclusion: These findings suggest that Aloe vera extract may be an effective natural supplement for improving the immune system function and reducing inflammation in the body. However, further research is needed to fully understand the underlying mechanisms for these effects and to determine the optimal doses and potential side effects.
Streptomyces sp. VYN22 Suşunun Tekstil Atık Sularında Boyar Madde Giderimine Etkisi
Authors: ÖZDEMİR KOÇAK Fadime , GENÇ BEKİROĞLU Yeliz , YAMAN Burcu
Published: January 2024

Tekstil endüstrisinde kullanılan boyalar ve boyar maddeler herhangi bir işlem görmeden sulara bırakıldıklarında toksik, kanserojen ve mutajenik etki göstererek çevre kirliliğine neden olmaktadır. Özellikle pigment boyar maddeler grubunda yer alan ve mikrobiyal bozunmaya karşı dirençli olan azo boyaların, tekstil kaynaklı atık sulardan bertarafı için biyoremediasyona dayalı çevre dostu yöntemler ilgi çekmektedir. Aktinobakteriler, doğada biyoremediasyon ve biyodegredasyon süreçlerine dahil olan ve organik madde ile karbon döngüsünde kilit rol oynayan bakterilerdir. Bu çalışmada, topraktan izole edilen Aktinobakteri izolatının 16S rRNA dizi analizleri ile tanımlanması ve Streptomyces sp. VYN22 olarak belirlenen bakterinin kullanılarak tekstil atıklarından azo boyaların boyar madde giderimi ile ortadan kaldırılması amaçlanmıştır. Bu izolatın 16S rRNA dizi analizlerine göre Streptomyces bobili tip türü ile %99,71 yakın akraba olduğu belirlenmiştir. Farklı pH’larda Colorsol Orange Deep tekstil boyası kullanılarak, Streptomyces sp. VYN22’ nin canlı, kuru ve liyofilize formlarının 0-10 saatlerdeki boyar madde giderimleri spektrofotometrik ölçümlerle incelenmiştir. Çalışma sonunda bu bakterilerin pH 4, 6 ve 10’da boyar madde gideriminde yüksek sonuçlar verdiği gözlemlenmiştir.
Protein Homology Modeling in the Low Sequence Similarity Regime
Authors: ESSIZ Sebnem
Published: January 2024

Predicting the 3-D structure of a protein from its sequence based on a template protein structure is still one of the most exact modeling techniques present today. However, template-based modeling is heavily dependent on the selection of a single template structure and the sequence alignment between target and template. Mainly when the target and template sequence identity is low, the error from the alignment introduces larger errors to the model structure. An iterative method to correct such alignment mistakes is used in this study with a benchmark set from CASP in the extremely low sequence-identity regime. This is a protocol developed and tested before and it evaluates the alignment quality by building rough 3-D models for each alignment. Then by using a genetic algorithm it iteratively creates a new set of alignments. Since the method evaluates models, not sequence alignments, structural features are automatically incorporated into the alignment protocol. In the current study, models from structural alignment have been built by Modeller program to show the maximum possible quality of the model that can be obtained from that template structure with the iterative modeling protocol. Then the results and correctly aligned segments from the iterative modeling protocol are analyzed. Finally, it has been shown that if a good local fragment assessment scoring function is developed, the correctly aligned segments exist in the pool of alignments created by the protocol. Thus, the improvement of modeling in the low sequence identity regime is conceivable.
Pengaruh Partisipasi, Tekanan Anggaran, dan Faktor-Faktor Organisasi Terhadap Kinerja Manajerial KAI
Authors: Ayu Ningsih Dinda , Fitriasuri
Published: January 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh partisipasi anggaran, tekanan anggaran, asimetri informasi, komitmen organisasi, dan profesionalisme terhadap kinerja manajerial. Penelitian ini menggunakan metode kuantitatif. Populasi dalam penelitian ini adalah seluruh staf manajerial PT. Kereta Api Indonesia (Persero) Divre III Palembang yang berjumlah 66 orang. Sampel yang digunakan diambil secara purposive sampling atau diambil berdasarkan kriteria. Teknik analisis yang digunakan adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa (1) Pengaruh X1 terhadap Y adalah 0,000 < 0,05 dan nilai t hitung 4,693 > t tabel 2,0003, berarti terdapat pengaruh X1 terhadap Y, (2) pengaruh X2 terhadap Y adalah 0.000 < 0.05 dan nilai t hitung 4,175 > t tabel 2,0003, berarti terdapat pengaruh X2 terhadap Y, (3) pengaruh X3 terhadap Y adalah 0,000< 0,05 dan nilai t hitung 3,244 > t tabel 2,0003, berarti  terdapat pengaruh X3 terhadap Y, (4) pengaruh X4 terhadap Y adalah 0,22 > 0,05 dan nilai t hitung 2,360 > t tabel 2,0003, berarti terdapat pengaruh X4 terhadap Y, (5) pengaruh X5 terhadap Y adalah 0,000 < 0,05 dan nilai t hitung 14,962 > t tabel 2,0003, berarti terdapat pengaruh X5 terhadap Y.
Kata kunci: Partisipasi Anggaran, Tekanan Anggaran, Asimetris Informasi, Komitmen Organisasi Dan Profesionalisme , Kinerja Manajerial
GREEN SUPPLY CHAIN AS A DEVELOPMENT DRIVER FOR A CIRCULAR ECONOMY
Authors:   Ural Federal University, Yekaterinburg, Russia, Lababidi M. R. , Zemzyulina V. Y. ,   Ural Federal University, Yekaterinburg, Russia, Slukina S. A. ,   Ural Federal University, Yekaterinburg, Russia
Published: January 2024

There is an increasing focus on climate change and environmental issues due to the rapid growth in fossil energy consumption driven by technological advances. Industrial enterprises are majorly responsible for various emissions, necessitating research into the business environmental liability. The subject of the study is the principles of environmentally friendly supply chain management in manufacturing companies. The study aims to determine the role of green supply chain in transition to a circular economy and to develop a management model for them. Thus, the following problems must be addressed: 1) exploring the conceptual relationship between the circular and green economies; 2) defining the essence of the term green supply chain management; 3) reviewing the existing practices for managing green supply chain at enterprises and identifying the key ones. In the course of the study, methods of theoretical analysis, synthesis, as well as scientific abstraction and generalization are used. Based on the findings of studying Russian and foreign scientific literature, as well as the non-financial reporting of domestic manufacturing companies, the most efficient practices for managing green supply chain at enterprises are identified, as well as their role in the transition to a circular economy.
SOSVINSKOYE PARISH SCHOOL IN THE HISTORY OF EDUCATION IN THE OB NORTH AT THE END OF THE 19TH AND BEGINNING OF THE 20TH CENTURIES
Authors:   Nizhnevartovsk State University, Nizhnevartovsk, Russia, Tsys O. P.
Published: January 2024

The relevance of the article is due to the insufficient study of the system of education in the North of West Siberia before the revolution. Scientific information sources on the history of school education in the Khanty-Mansiysk Autonomous Okrug are in a formative stage. Sosvinskoye parish accounting documents provided the basis for the research. The documents contain the information, which has allowed the author to restore the history of one of typical parish schools of the region and to narrate its first teachers and benefactors. The education development issues are considered in the frame of the history of Beryozovsky uyezd orthodox parish. Schools construction was dictated by the Executive Order of 1884 on organization of parish schools nationwide. A conclusion has been made that the Russian population of the region (priests, merchants and urban commoners) needed school education. It is highlighted in the article that the Beshkiltsev family played an important part in the material support of Sosvinskoye parish school.
KNOWLEDGE IS POWER: ORGANIZATION OF SCHOOLS DURING THE GREAT PATRIOTIC WAR (USING THE EXAMPLE OF OMSK SCHOOLS)
Authors:   Omsk State University named after F. M. Dostoevsky, Omsk, Russia, Nosova M. S.
Published: January 2024

Education during the Great Patriotic War was one of the priorities in arrangement of everyday life of home front. Often local authorities came up against situations where the number of schoolchildren exceeded the capabilities of schools in country towns. The purpose of the article is to reconstruct the way the educational process was arranged in a homefront town crowded with evacuated citizens. Based on the documentation of the historical archive of the Omsk region and the memoirs of war children, the author demonstrated the peculiarities of schools’ work under conditions of war and showed how the war had influenced the content of education and what impact it had on the reminiscences of war children.
Effect of Natural Bitumen on the Performance of Hot Asphalt Mixture‏
Authors: Ahmed Fatima , Latief Roaa , Albayati Amjad
Published: January 2024

For over a century, the global consumption of asphalt binder in asphalt mixture production has been substantial. In the Heet region (west of Iraq), two distinct forms of natural asphalt (NA) deposits exist: rock asphalt and sulfur spring asphalt. This study focused on using NA sourced from sulfur springs. The aim was to investigate the potential of incorporating NA into local asphalt mixtures. To achieve this, NA was heated to 163°C for varying durations. After heat treatment, laboratory tests were conducted on NA. The findings suggest that by heating NA for 20 hours, it conforms to Iraqi specifications in terms of physical properties. Furthermore, compared to conventional petroleum asphalt, treated NA showed greater resistance to temperature fluctuations, making it ideal for hotter climates. The study also found that NA enhances mechanical properties significantly. Specifically, the NA mixture recorded the highest indirect tensile strength, with a tensile strength ratio of 81.2%, a slight increase of 0.37% over traditional mixes. In summary, NA mixtures exhibit commendable performance. Given its abundance and affordability in Iraq, after considering heat treatment costs and environmental impact, NA holds promise for the future of asphalt concrete production for the construction of flexible pavement.
Event Sequence Based Fault Tree Analysis to Evaluate Minimal Combination of Event Sequences Leading to the Reactor Core Damage
Authors: Sony Tjahyani Damianus Toersiwi , Purba Julwan Hendry , Ekariansyah Andi Sofrany , Widodo Surip , Susyadı Susyadi , Tyas Ratih Luhuring
Published: January 2024

Probabilistic safety assessment has been widely used to evaluate nuclear power plant safety systems. It couples fault tree (FT) analysis and event tree (ET) analysis. The FT analysis is to develop failure scenarios, to quantify the failure probability, and to identify critical components. The ET analysis is to develop event sequences (ESs) leading to reactor core damage and quantify core damage frequency. Currently, there is no approach in probabilistic safety assessment that can be used to identify minimal combinations of safety system failures leading to reactor core damage. This study proposes an event sequence based fault tree analysis, which integrates the FT model with the ET model. The ET model is to identify the ESs leading to the reactor core damage. Meanwhile, the FT model is to identify minimal combinations of those ESs found in the ET model. The motivation of this study is how to identify critical safety systems in nuclear power plants to mitigate disturbances caused by a group of postulated initiating events to avoid core damage. To confirm the feasibility and the applicability of the proposed approach, the performance of the AP1000 passive core cooling system is evaluated. It is found that if an in-containment refueling water storage tank, an automatic depressurization system – full, an accumulator, a core make-up tank, and a passive residual heat removal work properly, the reactor core will remain intact. These results confirmed that the proposed approach could be applicable to identify minimal combinations of safety systems to keep the reactor core intact.
A Visual Approach to the Damage Diagnosis of Monoliths from the Monquira Archaeological Park - El Infiernito in Colombia
Authors: Öcal Ali Duran , Cramer Thomas , Kapur Selim Aziz
Published: January 2024

Monuments made of natural stones represent an important part of our world’s cultural heritage but deteriorate by the direct or indirect interaction of mineral and stone weathering. Application of damage indices improves stone damage diagnosis and is very appropriate for the determination of necessary preservation procedures as well as the long-term survey and maintenance of stone monuments. The sandstones used at El Infiernito in Villa de Leyva, Colombia, today show weathering damages of partly extreme intensity. In-situ surveys allowed damage mapping which help to identify major causes of damage and to understand their relationship with stone and environment characteristics. In this research, the state of deterioration of the pre-Hispanic phallic monoliths in the Archaeological Park of Monquira "El Infiernito", is presented in the form of monument visual posters. Based on the visualizing of weathering forms at representative monoliths, the state of deterioration is precisely characterized and evaluated. The monument mapping and photographic documentation method can also be useful for reassessing weather damage in the framework of long-term monitoring and maintenance of monuments. This article presents the methodology of mapping weathering forms of stone monuments by using a visual classification system developed over the years with various applications.
EMOJIS AS NONVERBAL CUES IN ONLINE COMMUNICATION: PERSPECTIVES ON CONFLICT RESOLUTION AND MISUNDERSTANDING PREVENTION
Authors: Grishechko Elizaveta G.
Published: January 2024

The study explores the role of emojis as nonverbal cues in conflict resolution and misunderstanding prevention in online communication on Reddit as indicators of speech aggression. Employing a mixed-methods approach and conducting both quantitative and qualitative analyses, the research investigates the frequency and patterns of emoji use in conflict and non-conflict threads, as well as their impact on conversation tone and outcomes. Findings reveal that positive emotion emojis, gesture emojis, and sarcasm/humor/irony emojis are most commonly used to manage challenging interactions and prevent misunderstandings. The study demonstrates that emoji use is more frequent in conflict threads compared to non-conflict threads, indicating the vital role emojis play in managing difficult interactions. Moreover, the results show that the use of emojis is associated with a higher likelihood of de-escalation, clarification of misunderstandings, and better conversation outcomes. In addition to supporting existing theoretical frameworks, such as Social Information Processing Theory and Media Richness Theory, the study provides practical insights into effective communication strategies and the design of digital spaces that facilitate healthier interpersonal communication. The findings have implications for online communication, suggesting that the strategic use of emojis can help humanize interactions, promote empathy, mitigate speech aggression and ultimately lead to mutual understanding and conflict resolution.
MANIPULATIVE SPEECH TACTICS IN ENGLISH BUSINESS MEDIA DISCOURSE: FUNCTIONAL ANALYSIS
Authors: Radyuk Alexandra V. , Panicheva Elena V. , Djagatspanyan Olga A.
Published: January 2024

The article deals with the manipulative potential of speech means of English business discourse in the media space. The study is a relevant topic, since the concept of business media discourse as a separate type of discourse has not yet been singled out. The material of the study comprised the public speeches of businessmen, commercial staff and economists for the period of 2021-2023. The authors resort to the method of functional discourse analysis, which substantiates the selection of speech means by a communicative purpose. At the same time, it is assumed that the goals can be main / secondary, open / hidden. The dynamics of the study of speech influence means in linguistics is described. As a result of the study, it was possible to identify speech tactics to enhance the manipulative impact and tactics to counteract speech manipulation: distracting questions; unwillingness to answer questions; pause before answering; question to question; refusal to explain; indignation over a minor issue; sudden change in behavior. The author comes to the conclusion that the study of the functional and pragmatic properties of business speech and the peculiarities of its implementation in media conditions can enrich the communicative competence of specialists.
Isquemia anastomótica por bevacizumab. Casos Clínicos
Authors: Cortes Fuentes Victor Julio Alejandro , Diaz Beneventi Mauricio Javier , Llanos Bravo Jose Luis
Published: January 2024

Objetivo: Presentar dos casos de isquemia anastomótica tardía por bevacizumab y compararlo con la literatura actual.Casos clínicos: Se exponen dos pacientes con cancer de recto metastásico, con manejo neoadyuvante, quirúrgico y adyuvancia que incluye bevacizumab, que presentan complicaciones isquémicas anastomóticas, evidenciadas con endoscopia, imágenes más biopsias dirigidas, resolviéndose en forma quirúrgica y biopsiando sitios perianastomóticos con cambios isquémicos.  Discusión: Existe evidencia en la literatura que reporta isquemias y filtraciones anastomóticas tardías con el uso de bevacizumab. Parece prudente considerar y sospechar en forma oportuna esta complicación, especialmente en pacientes con factores de riesgo.Conclusiones: Se debe considerar eventos isquémicos en territorios quirúrgicos, al uso de Bevacizumab. Mayor hincapié en pacientes con factores de riesgo como malnutrición, irradiación o sexo masculino. Considerar estudio dirigido anastomótico previo al inicio de bevacizumab. Dar relevancia a los tiempos de suspensión y reinicio de bevacizumab para evaluación de posibles complicaciones isquémicas.