bluuebunny/crossref_metadata_2025 huggingface dataset:
FIFTEEN YEARS OF SINGLE CENTER EXPERIENCE WITH STEM CELL TRANSPLANTATION FOR MULTIPLE MYELOMA: A RETROSPECTIVE ANALYSIS
Authors: Radocha Jakub , Maisnar Vladimír , Zavřelová Alžběta , Cermanová Melanie , Lánská Miriam , Kmoníček Miloslav , Jebavý Ladislav , Bláha Milan , Malý Jaroslav , Žák Pavel
Published: November 2014

Introduction: Autologous stem cell transplantation (ASCT) became standard of care for patients with multiple myeloma (MM) under the age of 65 years. We routinely perform ASCT for newly diagnosed MM since 1996 in our department. Patients and methods: We retrospectively analyzed all 285 transplants in 185 patients done for MM from January 1996 till December 2010. We analyzed overall survival (OS) and progression-free survival (PFS) regarding conditioning, stage, complete or very good partial remission (CR, VGPR) achievement, renal impairment, single vs. double transplant. Results: Estimated 10-years survival of the whole set of patients is 39% (median survival 95 months). Patients with renal impairment show same OS as those without (p = 0.22). Patients show similar overall survival and event free survival regardless of type of transplant. We observed better outcome in terms of overall survival in patients treated with new drugs (p = 0.0014). Reaching CR or VGPR was not translated into better OS (p = 0.30) and EFS (p = 0.10). Also stage of the disease and whether single or double transplant was used did not make any significant difference in the outcome. Conclusion: Stem cell transplantation greatly improved outcome of patients with MM. Poor outcome of allogeneic transplantation in our group of patients is related to high transplant related mortality (20% vs. 0%) and unexpected high relapse rate. There is a trend towards better survival, when new drugs are incorporated at any time in the course of the disease. This fact supports hypothesis that use of these drugs with ASCT should translate into better long-term outcome.
PROGRAM OF PALLIATIVE CANCER CARE – OUR EXPERIENCE
Authors: Slánská Iva , Kopecký Jindřich , Filip Stanislav
Published: November 2014

Introduction: Annually more than 27,000 persons die of cancer in the Czech Republic and the overall incidence of malignancies is still increasing. These data shows the need for affordable and good follow-up care especially for patients without any cancer treatment due to irreversible progression of tumor. Currently the outpatient palliative cancer care gets more into the forefront. Prerequisite for a well working outpatient palliative care is cooperation with general practitioners and home health care agencies. The purpose of the so called program of palliative cancer care is to guide a patient in palliative cancer care and to improve the cooperation among health care providers. Methods: During the period from January 2008 to October 2010 we evaluated in patient without any oncology treatment due to irreversible progression of tumor. Results: In palliative outpatient clinic we treated 446 patients, 119 of them received home care services with average length of 27.8 days. 77 patients died at home, 51 in health facilities and 41 in inpatient hospice care. Conclusion: We present pilot study focusing on outpatient palliative cancer care which shows the real benefit from early indication of palliative cancer care. This type of care allows patients to stay as long as possible at home among their close relatives.
THE CHERNOBYL ACCIDENT, THE MALE TO FEMALE RATIO AT BIRTH AND BIRTH RATES
Authors: Grech Victor
Published: November 2014

Introduction: The male:female ratio at birth (male births divided by total live births – M/T) has been shown to increase in response to ionizing radiation due to gender-biased fetal loss, with excess female loss. M/T rose sharply in 1987 in central-eastern European countries following the Chernobyl accident in 1986. This study analyses M/T and births for the former Soviet Republics and for the countries most contaminated by the event. Methods: Annual birth data was obtained from the World Health Organisation. The countries with the highest exposure levels (by 137Cs) were identified from an official publication of the International Atomic Energy Agency. All of the former Soviet states were also analysed and the periods before and after 1986 were compared. Results: Except for the Baltic States, all regions in the former USSR showed a significant rise in M/T from 1986. There were significant rises in M/T in the three most exposed (Belarus, Ukraine and the Russian Federation). The birth deficit in the post-Soviet states for the ten years following Chernobyl was estimated at 2,072,666, of which 1,087,924 are accounted by Belarus and Ukraine alone. Discussion: Chernobyl has resulted in the loss of millions of births, a process that has involved female even more than male fetuses. This is another and oft neglected consequence of widespread population radiation contamination.
NON-ADHERENCE IN SENIORS WITH DEMENTIA – A SERIOUS PROBLEM OF ROUTINE CLINICAL PRACTICE
Authors: Lužný Jan , Ivanová Kateřina , Juríčková Lubica
Published: November 2014

Background: Non-adherence to treatment in seniors with dementia is a frequent and potentially dangerous phenomenon in routine clinical practice which might lead to the inappropriate treatment of a patient, including the risk of intoxication. There might be different causes of non-adherence in patients with dementia: memory impairment, sensory disturbances, limitations in mobility, economical reasons limiting access to health care and medication. Non-adherence leads to serious clinical consequences as well as being a challenge for public health. Aim: to estimate prevalence of non-adherence in seniors with dementia and to study correlation between cognitive decline and non-adherence. Subjects and Methods: Prospective study, analyzing medical records of seniors with dementia admitted to the inpatient psychogeriatric ward in the Kromeriz mental hospital from January 2010 to January 2011. Cognitive decline measured by MMSE, prevalence of Non-adherence to treatment and reasons for patient Non-adherence were studied. Results: Non-adherence to any treatment was detected in 31.3% of seniors; memory impairment was the most common cause of non-adherence to treatment. Conclusion: In conclusion, non-adherence to treatment in the studied group of seniors with dementia correlates with the severity of cognitive impairment – a higher cognitive decline correlates with a higher risk of non-adherence to treatment.
RESISTANT CYCLIC VOMITING SYNDROME SUCCESSFULLY RESPONDING TO CHLORPROMAZINE
Authors: Özdemir Hasan H. , Bulut Serpil , Berilgen M. Said , Kapan Oktay , Balduz Metin , Demir Caner F.
Published: November 2014

Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent, stereotypic episodes of nausea, vomiting, and other symptoms, separated by intervals of comparative wellness. These episodes carry on for hours or days. The patient is healthy between the episodes and has no clinical finding. For the treatment of the CVS, antiemetic, antimigraine and sedative medications were used. However, in some cases CVS treatment is very difficult. We report about a young patient, who did not respond to many agents, but was succesfully treated with chlorpomazine.
Allelic Variation, Aneuploidy, and Nongenetic Mechanisms Suppress a Monogenic Trait in Yeast
Authors: Sirr Amy , Cromie Gareth A , Jeffery Eric W , Gilbert Teresa L , Ludlow Catherine L , Scott Adrian C , Dudley Aimée M
Published: November 2014

Clinically relevant features of monogenic diseases, including severity of symptoms and age of onset, can vary widely in response to environmental differences as well as to the presence of genetic modifiers affecting the trait’s penetrance and expressivity. While a better understanding of modifier loci could lead to treatments for Mendelian diseases, the rarity of individuals harboring both a disease-causing allele and a modifying genotype hinders their study in human populations. We examined the genetic architecture of monogenic trait modifiers using a well-characterized yeast model of the human Mendelian disease classic galactosemia. Yeast strains with loss-of-function mutations in the yeast ortholog (GAL7) of the human disease gene (GALT) fail to grow in the presence of even small amounts of galactose due to accumulation of the same toxic intermediates that poison human cells. To isolate and individually genotype large numbers of the very rare (∼0.1%) galactose-tolerant recombinant progeny from a cross between two gal7Δ parents, we developed a new method, called “FACS-QTL.” FACS-QTL improves upon the currently used approaches of bulk segregant analysis and extreme QTL mapping by requiring less genome engineering and strain manipulation as well as maintaining individual genotype information. Our results identified multiple distinct solutions by which the monogenic trait could be suppressed, including genetic and nongenetic mechanisms as well as frequent aneuploidy. Taken together, our results imply that the modifiers of monogenic traits are likely to be genetically complex and heterogeneous.
Natural course of subarachnoid hemorrhage is worse in elderly patients
Authors: Pahl Felix Hendrik , Oliveira Matheus Fernandes de , Rotta José Marcus
Published: November 2014

Aging is a major risk factor for poor outcome in patients with ruptured or unruptured intracranial aneurysms (IA) submitted to treatment. It impairs several physiologic patterns related to cerebrovascular hemodynamics and homeostasis. Objective Evaluate clinical, radiological patterns and prognostic factors of subarachnoid hemorrhage (SAH) patients according to age. Method Three hundred and eighty nine patients with aneurismal SAH from a Brazilian tertiary institution (Hospital do Servidor Público Estadual de São Paulo) were consecutively evaluated from 2002 to 2012 according to Fisher and Hunt Hess classifications and Glasgow Outcome Scale. Results There was statistically significant association of age with impaired clinical, radiological presentation and outcomes in cases of SAH. Conclusion Natural course of SAH is worse in elderly patients and thus, proper recognition of the profile of such patients and their outcome is necessary to propose standard treatment.
Head positioning for anterior circulation aneurysms microsurgery
Authors: Chaddad-Neto Feres , Doria-Netto Hugo Leonardo , Campos-Filho José Maria de , Ribas Eduardo Santamaria Carvalhal , Ribas Guilherme Carvalhal , Oliveira Evandro de
Published: November 2014

Objective To study the ideal patient's head positioning for the anterior circulation aneurysms microsurgery. Method We divided the study in two parts. Firstly, 10 fresh cadaveric heads were positioned and dissected in order to ideally expose the anterior circulation aneurysm sites. Afterwards, 110 patients were submitted to anterior circulation aneurysms microsurgery. During the surgery, the patient's head was positioned accordingly to the aneurysm location and the results from the cadaveric study. The effectiveness of the position was noted. Results We could determine mainly two patterns for head positioning for the anterior circulation aneurysms. Conclusion The best surgical exposure is related to specific head positions. The proper angle of microscopic view may minimize neurovascular injury and brain retraction.
Specificity and sensibility of 9-Itens Wearing-off Questionnaire in Brazilian Parkinson disease patient sample
Authors: Santos Jasper Guimarães , Chien Hsin Fen , Barbosa Egberto Reis
Published: November 2014

Objective (1) To evaluate whether the Nine Items Questionnaire (WOQ-9) for the detection of wearing-off (WO) in Parkinson Disease (PD), by means of its screening ability, is a helpful tool to assist neurologists in diagnosing WO; (2) To determine the sensitivity and the specificity of a free Brazilian Portuguese translation of WOQ-9. Method A sample obtained by convenience included 60 patients. The WOQ-9 was answered by the patients themselves before their routine consultations. The detection of the WO by the WOQ-9 was compared with the neurologist assessment. Statistical significance was 5%. Results The WOQ-9 showed sensitivity of 100%, specificity of 10.3%, positive and negative predictive values of 54.4% and 100% respectively. The identification of WO by the WOQ-9 was congruent in 54.5% of cases with neurological evaluation. Conclusion The WOQ-9 is a convenient screening tool to aid physicians to detect WO in PD patients, and it is a quick and easy self-administered questionnaire.
Prevalência de sintomas depressivos e ansiosos em pacientes com dor crônica
Authors: Pinheiro Ricardo Cardoso , Uchida Ricardo Riyoiti , Mathias Lígia Andrade da Silva Telles , Perez Marcelo Vaz , Cordeiro Quirino
Published: November 2014

Objetivos O presente estudo objetivou avaliar a prevalência de sintomas ansiosos e depressivos e relacioná-los com os diferentes tipos e magnitudes de dor crônica; também objetivou caracterizar a população de casos novos agendados para atendimento no ambulatório de dor crônica, no serviço onde o estudo foi realizado. Métodos Estudo de corte transversal, realizado em um ambulatório docente-assistencial para tratamento de dor crônica, realizado entre maio de 2012 e abril de 2013, com 125 pacientes. Instrumentos utilizados Questionário sociodemográfico, Escala Hospitalar de Ansiedade e Depressão (HAD) e Escala Visual Numérica (EVN) para aferir a intensidade de dor. Resultados Dor intensa foi referida por 64% (n = 80) dos pacientes. Ansiedade atingiu 65% (N = 82) dos pacientes e a depressão, 48% (N = 60). Houve correlação significante entre os mais altos escores de ansiedade (p < 0,001) e depressão (p < 0,001) com a intensidade de dor. A correlação entre intensidade de dor e sintomas ansiosos e depressivos foi positiva para dor crônica neuropática e mista. Os fatores sociodemográficos associados à intensidade de dor crônica foram: renda e religião para depressão, e tempo de dor para ansiedade. Conclusão O estudo mostrou elevada prevalência de sintomas depressivos e ansiosos em pacientes com dor crônica, assim como relação significante desses sintomas psiquiátricos com alguns tipos e intensidade de dor.
Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais: revisão sistemática da literatura e análise das metodologias utilizadas
Authors: Vilela Lúcia Helena Moraes , Juruena Mario Francisco
Published: November 2014

Objetivo Realizar revisão sistemática da literatura para conhecer a atividade do eixo hipotálamo-pituitária-adrenal (HPA) em deprimidos considerando-se as medidas basais dos hormônios e analisar criticamente as metodologias utilizadas. Métodos Foi realizada busca de artigos nas bases de dados PubMed e SciELO. Na primeira base de dados, introduziram-se as palavras-chave “depressive disorder” e “HPA axis”, e na segunda utilizaram-se os termos “depression” ou “depressão” e “HHA” ou “HPA axis”. Optou-se por pesquisa realizada em humanos adultos, em inglês e português, do ano 2000 até 2011. Resultados Dos 27 artigos selecionados, obtiveram-se como resposta do eixo HPA tanto hiperatividade como atividade desregulada, hipoatividade ou não alteração. Tais resultados dependem das variáveis e dos hormônios estudados, do fluido coletado – plasma, urina, saliva, líquido cefalorraquidiano – do horário de coleta, do número de coletas, da análise estatística utilizada, do subtipo de doença depressiva, entre outros. Conclusão: Os resultados não apresentam consenso em relação à atividade do eixo HPA. Considerando as variáveis estudadas, o eixo HPA, na maioria das vezes, apresenta-se disfuncional na presença da depressão.
O insight no transtorno bipolar: uma revisão sistemática
Authors: Silva Rafael de Assis da , Mograbi Daniel C. , Landeira-Fernandez J. , Cheniaux Elie
Published: November 2014

Objetivos Realizar uma revisão sistemática para compreender que fatores estão relacionados a uma maior ou menor consciência de morbidade no transtorno bipolar (TB), como o insight varia em função do estado afetivo e estabelecer uma comparação com outros transtornos mentais. Métodos Realizou-se uma revisão sistemática da literatura científica sobre o insight em pacientes com TB. Foram buscados estudos clínicos originais sobre o tema nas bases de dados Medline, ISI e SciELO. Os termos de busca empregados foram: “insight” OR “awareness” AND “bipolar” OR “mania” OR “manic”. Resultados Foram selecionados 55 artigos. O insight no TB parece ser mais prejudicado do que na depressão unipolar, porém menos do que na esquizofrenia. Com relação ao TB, um menor nível de insight está relacionado à presença de sintomas psicóticos e de alterações cognitivas. Além disso, um comprometimento do insight está associado a uma menor adesão ao tratamento. Por outro lado, uma maior preservação do insight pode estar associada a maior ideação suicida. Finalmente, a fase maníaca cursa com um nível inferior de insight quando comparada à fase depressiva ou de eutimia. Conclusão No TB, o insight está significativamente prejudicado, especialmente na mania. Diversos fatores clínicos parecem influenciar o nível de insight.
Normal aging and decision-making: a systematic review of the literature of the last 10 years
Authors: Wiesiolek Carine Carolina , Foss Maria Paula , Diniz Paula Rejane Beserra
Published: November 2014

Objective Conduct a systematic review to investigate whether healthy elderly have deficits in the decision-making process when compared to the young. Methods We performed a systematic search on SciELO, Lilacs, PsycINFO, Scopus and PubMed database with keywords decision making and aging (according to the description of Mesh terms) at least 10 years. Results We found nine studies from different countries, who investigated 441 young and 377 elderly. All studies used the IOWA Gambling Task as a way of benchmarking the process of decision making. The analysis showed that 78% of the articles did not have significant differences between groups. However, 100% of the studies that assessed learning did find relevant differences. Furthermore, studies that observed the behavior of individuals in the face of losses and gains, 60% of articles showed that the elderly has more disadvantageous choices throughout the task. Conclusion: The consulted literature showed no consensus on the existence of differences in performance of the decision-making process between old and young, but it is observed that the elderly has deficits in learning and a tendency to fewer advantageous choices.
O conhecimento local sobre a fauna edáfica e suas relações com o solo em agroecossistema familiar de base ecológica: um estudo de caso
Authors: Schiavon Greice de Almeida , Lima Ana Cláudia Rodrigues de , Schiedeck Gustavo , Schwengber José Ernani , Schubert Ryan Noremberg , Pereira Caroline Voser
Published: November 2014

O estudo foi realizado em uma propriedade agrícola familiar de base ecológica em Morro Redondo (RS), com intuito de analisar o conhecimento local sobre a fauna edáfica e as práticas de manejo do solo no sistema de produção de hortaliças. A família agricultora ressaltou a função das minhocas no solo, além de compreender que as práticas de manejo influenciam a fauna edáfica. A densidade da fauna edáfica foi maior no inverno, porém com diminuição da diversidade e aumento da dominância. O potencial do uso do conhecimento local como um importante aliado ao conhecimento acadêmico na avaliação da influência das práticas de manejo na fauna edáfica é discutido neste artigo
Adaptabilidade e estabilidade de genótipos de café no cultivo orgânico em Minas Gerais
Authors: Moura Waldênia de Melo , Lima Paulo César de , Lopes Vanessa Schiavon , Carvalho Cássio Francisco Moreira de , Cruz Cosme Damião , Oliveira Ana Maria Cruz e
Published: November 2014

Este trabalho teve como objetivo comparar a adaptabilidade e estabilidade de cultivares de café quanto à média de produtividade anual e de biênios, pelo método de EBERHART & RUSSEL (1996), e selecionar cultivares de café para o cultivo orgânico em Minas Gerais. Os experimentos foram conduzidos em três locais, em delineamento de blocos casualizados com trinta genótipos e três repetições. Uma análise se baseou na produtividade média anual de quatro colheitas (2005/2006, 2006/2007, 2007/2008 e 2008/2009) com o total de doze ambientes. A outra análise considerou a média de dois biênios (2005/2006 e 2006/2007; 2007/2008 e 2008/2009) com o total de seis ambientes. A análise em que se considerou a média da produtividade do biênio apresentou redução expressiva do coeficiente de variação ambiental. Por isso, foi possível identificar mais cultivares com adaptabilidade e estabilidade para o cultivo orgânico. Conclui-se que a análise de adaptabilidade e estabilidade com base na produtividade de biênio é mais segura para a seleção de cultivares. Considerando essa premissa, as cultivares 'Catucaí Vermelho 36/6', 'Catuaí Vermelho IAC 15' e 'Siriema 842' são indicadas somente para os ambientes favoráveis. As cultivares 'Sabiá 708', 'IBC Palma 1', 'Catucaí Amarelo 24/137', 'Oeiras MG 6851' e as linhagens H518 e H514 são indicadas para o cultivo orgânico em locais com ambientes similares aos avaliados em Minas Gerais.
Biometry by ultrasonography of the epaxial and pelvic musculature in equines trained with Pessoa's rein
Authors: Oliveira Kátia de , Soutello Ricardo Velludo Gomes de , Fonseca Ricardo da , Lopes Andréa Machado , Santos Paulo César da Silva , Santos Juliana Mara Freitas , Massarelli Ana Cristina , Rodrigues Juliana Silva , Vera João Henrique da Silva
Published: November 2014

This study aimed to evaluate the use of Pessoa's rein in training equine, as a support in exercise training, on biometry by ultrasonography of the epaxial (Longíssimus Dorsi, Gluteus Medius e Musculus Multifidus) and pelvic musculature (Biceps Femoris e Semitendinosus). Thereby, eight Quarter Horse mares was used, with eight years on average age, 400kg of body weight, trained with the Pessoa's rein twice a week, for two months. Variables were measured before and after training, consisting of assessment thickness (cm) of the Longíssimus Dorsi and cross-sectional area (cm2) of muscles, Gluteus Medius, Biceps Femoris, Semitendinosus and Musculus Multifidus. It observed a significant effect of training with Pessoa's rein, on the Biceps Femoris (P<0.01) and Musculus Multifidus (P<0.01), which the average cross-sectional area at the final evaluation were of 28.66cm2 and 14.29cm2, respectively. Thus it can be conclude that training with Pessoa's rein modifies muscular function, promoting hypertrophy Musculus Multifidus and Biceps Femoris of horses
Conservação à temperatura ambiente de uma bebida a base de soro de leite envasada a quente
Authors: Luiz Lívia Maria Pinheiro , Rocha Juliana de Cássia Gomes , Sá João Paulo Natalino de , Brandão Sebastião César Cardoso , Araújo Emiliane Andrade , Carvalho Antônio Fernandes de
Published: November 2014

A indústria de leite e derivados no Brasil lança todos os anos diversos novos produtos no mercado, incluindo produtos de alto valor nutricional e tecnologia de fabricação de baixo custo. Focando neste tema, foi avaliado o efeito do envase a quente de uma bebida a base de soro de leite tratada termicamente após fermentação, e sua conservação à temperatura ambiente, por 84 dias. Durante o processamento, utilizou-se um tratamento térmico brando, aliado ao baixo pH, para que a bebida pudesse ser armazenada a temperatura ambiente. Garrafas PET de 250 mL foram utilizadas para o envase a quente do produto. Para avaliar sua estabilidade durante o armazenamento, foram realizadas periodicamente análises físico-químicas, microbiológicas e análise sensorial. Os resultados obtidos foram analisados por análise de variância e teste de Tukey para comparação de médias. Análises físico-químicas e microbiológicas indicaram que a bebida manteve-se estável; entretanto, o sabor foi alterado ao longo do armazenamento. O baixo custo do processamento e embalagem são benefícios do produto avaliado, podendo-se concluir que a bebida é uma boa forma para a utilização do soro de leite. Uma grande vantagem deste produto é o seu armazenamento à temperatura ambiente, dispensando o uso da refrigeração durante o transporte e acondicionamento em supermercados.
Aplicação de modelos de regressão aleatória utilizando diferentes estruturas de dados
Authors: Sousa Júnior Severino Cavalcante de , Faro Lenira El , Bignardi Annaiza Braga , Cardoso Vera Lucia , Machado Paulo Fernando , Albuquerque Lucia Galvão de
Published: November 2014

Foram utilizadas 3.202 primeiras lactações de vacas da raça Holandesa de quatro fazendas da região Sudeste, para verificar a influência da estrutura de dados de produção de leite sobre os parâmetros genéticos. Foram testados quatro arquivos com diferentes estruturas: controles semanais (CS), arquivo mensal (CM), bimestral (CB) e trimestral (CT), com 122.842, 30.883, 15.837 e 12.702 controles, respectivamente. Um modelo de regressão aleatória foi empregado nas análises, considerando os efeitos genético aditivo e o de ambiente permanente de animal, como aleatórios. Os efeitos fixos, grupos de contemporâneos (GC) foram comuns para todos os arquivos de dados e foram compostos por fazenda, mês e ano do controle, além da co-variável idade da vaca ao parto (regressão linear e quadrática). As estimativas de herdabilidade apresentaram tendências mais semelhantes entre os arquivos de dados CS, CM e CB. O arquivo de dados CB apresentou estimativas de parâmetros genéticos com as mesmas tendências e magnitudes que os arquivos CS e CM, permitindo afirmar que não houve influência da estrutura dos dados sobre as estimativas dos componentes de (co)variância e que o controle leiteiro poderia ser realizado em uma estrutura CB
Gestão da cadeia de suprimento e vantagem competitiva relacional nas indústrias têxtil e de calçados
Authors: Viana Fernando Luiz Emerenciano , Barros Neto José de Paula , Añez Miguel Eduardo Moreno
Published: November 2014

Esse artigo investigou a contribuição da gestão da cadeia de suprimento para a vantagem competitiva relacional nos setores têxtil e de calçados, por meio de um estudo de casos múltiplos. Foram analisadas as características do relacionamento com os fornecedores e as relações das empresas com componentes do ambiente institucional, bem como a influência destas na vantagem competitiva, além das diferentes fontes de vantagem competitiva percebidas pelas empresas. As características dos relacionamentos com os fornecedores do setor de calçados apresentam maior alinhamento aos pressupostos da gestão da cadeia de suprimento e contribuem de forma mais relevante para a vantagem competitiva. As relações com componentes do ambiente institucional, em ambos os setores, levam a uma situação de paridade competitiva em relação aos concorrentes. Com relação às fontes de vantagem competitiva, a inovação de produto predomina nos dois setores.
Galictis cuja (Mammalia): an update of current knowledge and geographic distribution
Authors: Poo-Muñoz Daniela A. , Escobar Luis E. , Peterson A. Townsend , Astorga Francisca , Organ John F. , Medina-Vogel Gonzalo
Published: November 2014

The lesser grison (Galictis cuja) is one of the least-known mustelids in the Neotropics, despite its broad range across South America. This study aimed to explore current knowledge of the distribution of the species to identify gaps in knowledge and anticipate its full geographic distribution. Eighty-nine articles have mentioned G. cuja since 1969, but only 13 focused on the species. We generated a detailed model of the species' potential distribution that validated previous maps, but with improved detail, supporting previous southernmost records, and providing a means of identifying priority sites for conservation and management of the species.
Eficiência da seleção de progênies de café F4 pela metodologia de modelos mistos (REML/BLUP)
Authors: Pereira Thamiris Bandoni , Carvalho João Paulo Felicori , Botelho César Elias , Resende Marcos Deon Vilela de , Rezende Juliana Costa de , Mendes Antônio Nazareno Guimarães
Published: November 2014

Objetivou-se verificar a eficiência da seleção de cafeeiros em geração F4 para características agronômicas e resistência a doenças mediante o emprego da metodologia de modelos mistos de Henderson. O experimento foi instalado na Fazenda Experimental da EPAMIG, em Machado, MG, sendo utilizadas progênies F4 derivadas do cruzamento entre cultivares do grupo Icatu com Catuaí Amarelo IAC 62 e IAC 17 e com as progênies IAC 5002 e IAC 5010. O delineamento experimental utilizado foi o látice com quatro repetições e as avaliações foram realizadas ao longo de dois anos (2010 e 2011). Foram avaliadas as seguintes características: produção (litros planta-1), reação à ferrugem, vigor vegetativo e reação à cercosporiose. Foram utilizados o procedimento REML/BLUP para estimar os parâmetros genéticos, o índice de seleção de Mulamba e Mock a fim de verificar os ganhos para múltiplos caracteres, a acurácia e eficiência, calculadas a partir do diferente número de medições e, ainda, o agrupamento multivariado de progênies pelo método de Tocher. Verificou-se, a partir da análise dos parâmetros genéticos, um maior sucesso na seleção entre famílias para todas as características avaliadas. A adoção de quatro colheitas poderá elevar a acurácia a 80% na seleção de indivíduos para as características produção, reação à ferrugem e vigor vegetativo. A seleção das 12 melhores progênies para caracteres múltiplos pelo índice de Mulamba e Mock proporcionaria um ganho médio de 70,4%.
Clones de copa de seringueira resistentes ao mal-das-folhas para o cultivo na Amazônia tropical úmida
Authors: Moraes Larissa Alexandra Cardoso , Moraes Vicente Haroldo de Figueiredo , Moreira Adônis , Cordeiro Everton Rabelo , Oliveira Maria Cristina Neves de
Published: November 2014

O objetivo deste trabalho foi avaliar o desempenho de 11 clones de copa de seringueira de Hevea pauciflora × H. guianensis, H. guianensis × H. pauciflora, H. pauciflora × H. rigidifolia e H. pauciflora resistentes ao fungo Microcyclus ulei, causador do mal-das-folhas, sobre o painel de CNS AM 7905 (seleção primária de H. brasiliensis), durante 14 anos nas condições edafoclimáticas da Amazônia tropical úmida. Foram avaliados: produtividade de borracha seca durante sete anos, aspectos anatômicos, características fisiológicas do látex, estado nutricional das plantas e métodos de sangria (oriental e amazônica). Os clones de copa CPAA C 01, 06 e 45 produziram, na média, mais de 1,4 t ha- 1 ano- 1 de borracha seca, seguido pelos clones CPAA C 13, 14, 15, 16 e 20, com produtividade acima de 1,0 t ha-1 ano- 1, enquanto os clones CPAA C 18, CPAA C 33 e CBA 2 registraram produtividade inferior a 0,9 t ha-1 ano- 1. A concentração de Pi e Mg no látex e os teores foliares de K e Cu estão relacionados com a produtividade dos clones CPAA C 01, 06 e 45, sendo esses fatores importantes no programa de seleção de clones de copa de seringueira. Em plantio comercial, o método da sangria oriental é mais eficiente que a amazônica.
Depressão endogâmica e heterose de híbridos de populações F2 de milho no estado de São Paulo
Authors: Bernini Cristiani Santos , Paterniani Maria Elisa Ayres Guidetti Zagatto , Duarte Aildson Pereira , Gallo Paulo Boller , Guimarães Paula de Souza , Rovaris Sara Regina Silvestrin
Published: November 2014

A heterose e a depressão por endogamia são fenômenos complementares importantes nas estratégias de melhoramento, como para a obtenção de híbridos convencionais e melhoramento de populações. Este trabalho teve por objetivos avaliar híbridos de populações F2 de milho quanto aos caracteres agronômicos, estimar a heterose em relação à média dos pais e determinar a depressão endogâmica na obtenção das populações de genitores F2. Foram avaliados 10 híbridos de populações F2, cinco populações de genitores F2 e os respectivos híbridos comerciais (HC) quanto aos seguintes caracteres agronômicos: florescimento masculino (FM), altura de planta (AP), altura de espiga (AE) e massa de grãos (MG), em dois locais do estado de São Paulo, Mococa e Palmital, sob delineamento de blocos ao acaso. A estimativa de depressão por endogamia ao passar da geração F1 para F2 variou de 18,0% no HC12 a 48,1% no HC10, para MG. A heterose média em relação à média dos pais obtida para massa de grãos foi de 37,2%, representada pela elevada produtividade alcançada pelos híbridos de F2. Baseando-se nesses resultados foi possível evidenciar dois híbridos de populações F2 que apresentaram potencial produtivo, alta heterose média e populações F2 com potencial para extração de linhagens.
Comparative study of five different surgical techniques for the treatment of morbid obesity using BAROS
Authors: MARCHESINI João Batista , NICARETA Jean Ricardo
Published: November 2014

BACKGROUND: The obesity is an universal disease of epidemic proportions and in a growing prevalence. It is one of the main public health problems and it will be inexorably the largest problem of the developing world. The morbid obesity is associated to serious diseases, reducing the life perspective, increasing the morbility and mortality. Several strategies of losing weight were proposed; however, the bariatric surgeries are today the most effective treatment for this disease. The BAROS is the most simple, practical and efficient method to evaluate the results in the bariatric surgeries. AIM: To compare five surgical techniques for the treatment of morbid obesity using BAROS. METHOD: The sample is constituted of 102 patients submitted to Fobi-Capella (23 patients), Scopinaro (21 patients), duodenal switch (20 patients), vertical banded gastroplasty of Mason (15 patients) and the adjustable gastric band (23 patients), evaluated 12 months after the surgeries using BAROS. RESULTS: The analysis of the final result of BAROS for the classification demonstrated that good, very good and excellent results were obtained in 100% of the patients in the group of duodenal switch; 91,3% in Fobi-Capella; 85,7% in Scopinaro; 60% in Mason; and 56,5% in adjustable gastric band. The final result of BAROS for the total score demonstrated that the group of duodenal switch obtained 6,3 points; the Fobi-Capella 5,1 points; the Scopinaro 4,8 points; the Mason 3,0 points; and the adjustable gastric band 2,9 points (p<0,0001). CONCLUSION: The duodenal switch is the best technique for the surgical treatment of the morbid obesity, in the following 12 months post-surgical clinical procedures, according to BAROS.
Use of positive pressure in the bariatric surgery and effects on pulmonary function and prevalence of atelectasis: randomized and blinded clinical trial
Authors: BALTIERI Letícia , SANTOS Laisa Antonela , RASERA-JUNIOR Irineu , MONTEBELO Maria Imaculada Lima , PAZZIANOTTO-FORTI Eli Maria
Published: November 2014

BACKGROUND: In surgical procedures, obesity is a risk factor for the onset of intra and postoperative respiratory complications. AIM: Determine what moment of application of positive pressure brings better benefits on lung function, incidence of atelectasis and diaphragmatic excursion, in the preoperative, intraoperative or immediate postoperative period. METHOD: Randomized, controlled, blinded study, conducted in a hospital and included subjects with BMI between 40 and 55 kg/m2, 25 and 55 years, underwent bariatric surgery by laparotomy. They were underwent preoperative and postoperative evaluations. They were allocated into four different groups: 1) Gpre: treated with positive pressure in the BiPAP mode (Bi-Level Positive Airway Pressure) before surgery for one hour; 2) Gpos: BIPAP after surgery for one hour; 3) Gintra: PEEP (Positive End Expiratory Pressure) at 10 cmH2O during the surgery; 4) Gcontrol: only conventional respiratory physiotherapy. The evaluation consisted of anthropometric data, pulmonary function tests and chest radiography. RESULTS: Were allocated 40 patients, 10 in each group. There were significant differences for the expiratory reserve volume and percentage of the predicted expiratory reserve volume, in which the groups that received treatment showed a smaller loss in expiratory reserve volume from the preoperative to postoperative stages. The postoperative radiographic analysis showed a 25% prevalence of atelectasis for Gcontrol, 11.1% for Gintra, 10% for Gpre, and 0% for Gpos. There was no significant difference in diaphragmatic mobility amongst the groups. CONCLUSION: The optimal time of application of positive pressure is in the immediate postoperative period, immediately after extubation, because it reduces the incidence of atelectasis and there is reduction of loss of expiratory reserve volume.
Polimorfismos genéticos e carcinoma de pulmão de células não pequenas: os paradigmas do futuro
Authors: Mello Ramon Andrade Bezerra de
Published: November 2014

O presente artigo faz uma abordagem de questões atuais sobre os polimorfismos genéticos, que têm sido objeto de estudo translacional no contexto do carcinoma de pulmão de células não pequenas. Além disso, discute os novos potenciais biomarcadores de risco e prognóstico.
Reduced bioavailability of cyclosporine A in rats by mung bean seed coat extract
Authors: Li Xiping , Gao Ping , Zhang Chengliang , Wu Tao , Xu Yanjiao , Liu Dong
Published: November 2014

Mung bean seed coat (MBSC) is a healthcare product in Asian countries. The aim of this study was to investigate the effect of an MBSC ethanol extract on the bioavailability of cyclosporine A (CsA) in rats. Rats were orally dosed with CsA alone or in combination with MBSC ethanol extracts (500 mg/kg, p.o.). The blood levels of CsA were assayed by liquid chromatography with an electrospray ionization source and tandem mass spectrometry (LC-MS/MS). The everted rat intestinal sac technique was used to determine the influence of MBSC on the absorption of CsA. The results reveal that combined CsA intake with MBSC decreased the Cmax, AUC0-t, t1/2z and MRT0-t values of CsA by 24.96%, 47.28%, 34.73% and 23.58%, respectively (P<0.05), and significantly raised the CL/F by 51.97% (P<0.01). The in vitro results demonstrated that significantly less CsA was absorbed (P<0.05). The overall results indicate that after being concomitantly ingested, MBSC reduced the bioavailability of CsA, at least partially, in the absorption phase.
Anti-inflammatory, analgesic, and immunostimulatory effects of Luehea divaricata Mart. & Zucc. (Malvaceae) bark
Authors: Rosa Roseane Leandra da , Nardi Geisson Marcos , Januário Adriana Graziele de Farias , Boçois Renata , Bagatini Katiane Paula , Bonatto Sandro José Ribeiro , Pinto Andrea de Oliveira , Ferreira João Ronaldo Notargiacomo , Mariano Luisa Nathália Bolda , Niero Rivaldo , Iagher Fabíola
Published: November 2014

Luehea divaricata (Malvaceae) is a plant widely used for treatment of various inflammatory and infectious conditions; however few reports discuss its biological properties. The aim of this study was to evaluate the anti-inflammatory and analgesic effects as well as the macrophage activity in mice treated with the hydroalcoholic crude extract of L. divaricata(CLD). Thin layer chromatography revealed presence of epicathequin, stigmasterol, lupeol and α,β-amyrin in the extract. To evaluate the anti-inflammatory and analgesic activities, animals were subjected to paw edema induced by carrageenan test, writhing, formalin and capsaicin tests. Immunomodulatory activity was evaluated by adhesion and phagocytic capacity, lysosomal volume, and reactive oxygen species (ROS) production by peritoneal macrophages, after daily treatment with CLD for 15 days. CLD promoted reduction in paw edema (36.8% and 50.2%; p<0.05 at doses of 100 and 300 mg/kg, respectively), inhibited writhing behavior at the higher dose (64.4%, p<0.05), reduced formalin reactivity (81.2% and 91.6% at doses of 100 and 300 mg/kg, respectively, p<0.05), and reduced capsaicin reactivity by 63.9% (300 mg/kg). CLD (200 mg• kg-1• day-1) increased phagocytosis capacity of macrophages (~3 fold, p<0.05), neutral red uptake (~50%, p<0.001), and ROS production (~90%, p<0.001). These data suggest that CLD possesses anti-inflammatory, analgesic and immunostimulatory properties.
Classification and Diagnosis of Axial Spondyloarthritis — What Is the Clinically Relevant Difference?
Authors: Braun Jurgen , Baraliakos Xenofon , Kiltz Uta , Heldmann Frank , Sieper Joachim
Published: November 2014

Objective.

The Assessment of Spondyloarthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) have added nonradiographic axSpA (nr-axSpA) to the classic ankylosing spondylitis (AS) as defined by the modified New York criteria. However, some confusion remains about differences between classification and diagnosis of axSpA. Our objective was to analyze differences between classification and diagnostic criteria by discussing each feature of the classification criteria based on real cases.

Methods.

The clinical features of the ASAS classification criteria were evaluated in relation to their significance for an expert diagnosis of axSpA. Twenty cases referred to our tertiary center outpatient clinic were selected because of an incorrect diagnosis of axSpA: 10 cases in which axSpA had been excluded initially because the classification criteria were not fulfilled, and 10 patients who had been previously diagnosed with axSpA because the classification criteria were fulfilled. Upon reevaluation, the former were diagnosed with axSpA while the latter had other diseases.

Results.

All items that are part of the classification criteria show some variability related to their relevance for a diagnosis of axSpA. There are clinical features suggestive of axSpA that are not part of the classification criteria. Misinterpretation of imaging procedures contributed to false-positive results. Rarely, other diseases may mimic axSpA.

Conclusion.

Because the sensitivity and specificity of the axSpA classification criteria have been around 80% in clinical trials, some false-positive and false-negative cases were expected. It is hoped that their detailed description and discussion will help to increase the understanding of diagnosing axSpA in relation to the ASAS classification criteria.
Je ne veux pas trop te coûter, tu sais ?
Authors: Laé Jean-François
Published: November 2014

Lorsque la radiation de Pôle emploi menace, il faut savoir justifier, expliquer son parcours, ses incohérences et ses méandres, pour ne pas tout perdre.
Chômage fictif
Authors: Charrin Ève
Published: November 2014

Pourquoi le chômage, les chômeurs, sont-ils absents de la fiction française contemporaine ?
Controverses sur le vote frontiste
Authors: Padis Marc-Olivier
Published: November 2014

Comment expliquer l’installation du Front national dans la vie politique française ? Faut-il s’attacher aux raisons politiques, sociologiques ? Derrière la difficulté à saisir le profil des électeurs frontistes, trois polémiques récurrentes opposent les analystes du vote, qui portent sur le vote ouvrier, le vote catholique et le vote périurbain.
Les sunnites, l'Irak et l'État islamique
Authors: Benraad Myriam
Published: November 2014

La montée en puissance de Da‘ech braque à nouveau les projecteurs sur l’Irak. Pour mieux comprendre les affrontements en cours, il faut revenir à la situation du pays, de l’invasion américaine à l’installation de Nouri Al-Maliki au pouvoir. Progressivement marginalisés, les sunnites se trouvent aujourd’hui dans une position charnière, dans leur rapport à l’État islamique comme au gouvernement irakien.
A comparison between quantitative gated myocardial perfusion scintigraphy and strain echocardiography as indicators of ventricular functions in patients with anterior myocardial infarction
Authors: Karacavus Seyhan , Celik Ahmet , Tutus Ahmet , Kula Mustafa , Oguzhan Abdurrahman , Ozdogru Ibrahim , Kalay Nihat
Published: November 2014

The purpose of this study is to compare the strain echocardiographic and scintigraphic parameters for evaluating of the left ventricular (LV) functions in patients with anterior myocardial infarction (MI). Fifty-four patients (male/female: 36/18; mean age 62 ± 13 years) with anterior MI were prospectively enrolled. All patients were performed gated myocardial perfusion scintigraphy gated single-photon emission computed tomography (GSPECT) and echocardiography (EC). GSPECT data were processed and analyzed using 4D-MSPECT (4DM, Invia Medical Imaging Solutions, Ann Arbor, MI, USA). The echocardiographic strain (S) and strain rate (SR) values were calculated. The results obtained by these techniques were compared each other. A total of 918 segments of LV wall were evaluated. In all patients, 385 segments were automatically scored as normokinetic, 206 as hypokinetic, 122 as akinetic, 205 as dyskinetic and 300 as normal thickening, 348 as decrease thickening and 270 as no thickening. The means of S and SR values in thickening and motion score groups according to GSPECT were statistically different from each other (P < 0.001). There was a negative significant correlation between LV wall thickening sum score and S and SR and between LV wall motion sum score and S and SR (P < 0.001). There was a good correlation between GSPECT and echocardiographic LV-ejection fraction (r = 0.7, P < 0.001). GSPECT and strain EC are similar in quantitative grading of the severity of regional and global myocardial dysfunction in patients with anterior MI and these techniques provide valuable diagnostic information.
False negative 99m Tc-hydroxymethane diphosphonate three-phase bone scintigraphy and 99m Tc-besilesomab scan in detecting tibia osteomyelitis concomitant with necrotizing fasciitis
Authors: Tan Teik , Lee Boon
Published: November 2014

We described a case of 51-year-old female patient presented with a right calf necrotising fasciitis (NF) where osteomyelitis (OM) was suspected. 99m Tc-hydroxymethane diphosphonate three-phase bone scintigraphy and 99m Tc-besilosomab scan failed to demonstrate classical features of OM. The final diagnosis was only made by isolating Acinetobacter sp. in both intra-operative bone and tissue cultures from below-knee amputation. As conclusions, the detection of lower limb OM by 99m Tc-besilosomab scan is not easy when there is concurrence overlying NF. The unusual three-phase bone scan finding of pericortical accumulation of tracer as an early sign of OM is highlighted in this case.
99m Tc dtpa renogram indentifies bochdalek hernia with an intra thoracic kidney as its content
Authors: Padma Subramanyam , Pande Shantanu , Sundaram Palaniswamy
Published: November 2014

Congenital diaphragmatic hernia (CDH) is a rare anomaly with reported incidence of 1 in 16,000 and is associated with herniation of stomach, intestinal loops, spleen, and kidney through a chest wall defect. We report a case of 1-year-old male child with history of recurrent fever and non-visualization of left kidney on ultrasonogram. Patient was referred to us to look for ectopic left kidney. 99m Tc-diethylenetriaminepentaacetic acid renogram was performed. An ectopically placed intrathoracic left kidney was identified. Subsequently a chest X-ray was done that showed bowel loops and diagnosis of CDH was confirmed. The patient underwent thoracoscopic repair of CDH and hernial contents were found to be left kidney, intestinal loops and spleen.
The Photographs of Terence V. Powderly
Authors: Shepherd William John
Published: November 2014

Terence Vincent Powderly (1849–1924) was a national celebrity who personified the American labor movement in the late nineteenth century during his tenure (1879–93) as head of the Knights of Labor, the era's largest organization of American workers. Unions were especially important in his native Pennsylvania and his reform efforts found a sympathetic political audience. He was also a dedicated public servant with three terms (1878–84) as a progressive mayor of Scranton and a reform-minded federal bureaucrat (1897–1924) in Washington, DC. In addition, he supported Irish nationalism, serving as a member of the secret pro-independence Clan Na Gael society and the Irish Land League political organization that favored the rights of tenant farmers. He was often photographed, or had photographs given to him, and late in life became an avid photographer with thousands of photographs preserved in his personal papers housed at the Catholic University of America in Washington, DC.