bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS KESELAMATAN DAN KESEHATAN KERJA MENGGUNAKAN METODE HIRARC DI PT XYZ
Authors: Gea Hikmat Valianto , Febrian Muhammad Rifky Shafwan , Praja Naufal Sukma
Published: August 2024

Potensi kecelakan kerja dapat terjadi pada setiap aktifitas pekerjaan. Kecelakaan kerja dapat diakibatkan oleh beberapa faktor, seperti mesin-mesin yang digunakan dan kelalaian pekerja. Pada aktivitas pekerjaan di PT XYZ terdapat beberapa potensi yang dapat menyebabkan kecelakaan kerja. Penelitian ini bertujuan untuk mengidentifikasi potensi kecelakaan kerja yang akan terjadi sehingga dapat dilakukan pencegahan. Dalam penelitian ini upaya untuk mengindentifikasi risiko dan terjadinya kecelakaan kerja dilakukan menggunakan metode Hazard Identification Risk Assessment and Risk Control (HIRARC), dengan melakukan indentifikasi bahaya (hazard identification) penilaian risiko (risk assessment) dan pengendalian risiko (risk control). Hasil dari penelitian ini adalah terdapat 4 aktifitas pekerjaan dengan potensi bahaya terjadinya kecelakaan kerja, aktifitas pekerjaan tersebut adalah Cutting, Welding, Material Handling, dan Bending. Untuk risk level pada penilitian risiko terdapat 4 kategori, yaitu ekstrim, tinggi, sedang, dan rendah. Terdapat 2 aktifitas pekerjaan yang dikategorikan masuk kedalam risiko ekstrim, sedangkan risiko tinggi dan risiko sedang masing-masing terdapat 1 aktifitas pekerjaan. Pengendalian risikonya adalah memodifikasi APD dan penerapan SOP pada setiap aktifitas pekerjaan dan SOP pengoprasian mesin secara baik dan benar dan perusahaan melakukan evaluasi secara berkala.
Перші дані стосовно сезонного розвитку самшитової вогнівки у зелених насадженнях Житомира
Authors: Андреєва О. Ю. , Мартинчук І. В. , Іванюк Т. М. , Матковська С. І. , Марчук Д. О.
Published: August 2024

Самшитова вогнівка Cydalima perspectalis (Walker, 1859) (Lepidoptera: Crambidae) має походження зі східної Азії. Проникла в Європу у 2006 р., наразі відома в більшості областей України. У межах ареалу спроможна мати від двох до п’яти поколінь на рік, спричиняючи ослаблення й відпад рослин роду Buxus L. Метою наших досліджень було виявити особливості сезонного розвитку самшитової вогнівки в зелених насадженнях Житомира для визначення оптимальних термінів моніторингу поширення й розвитку цього шкідника та заходів його знищення. У Ботанічному саду Поліського національного університету імені героїв-десантників самшитова вогнівка розвивається у двох повних поколіннях. Гусениці третього покоління починаючи з вересня уповільнюють розвиток і впадають у діапаузу у ІІІ–IV віках. Кінець першого періоду льоту імаго (від третьої декади червня до третьої декади липня) наближений до початку другого періоду льоту імаго (від першої декади серпня до першої декади вересня). Можливість перекривання розвитку особин двох поколінь свідчить про існування загрози заселення нових кущів самшиту протягом більшої частини літа. Вихід гусениць із діапаузи та відновлення живлення навесні відбувається приблизно після дати стійкого переходу температури через 10 °С. Саме в цей період доцільно здійснювати огляд кущів і за необхідності – їхній захист. Одержані дані щодо сезонного розвитку самшитової вогнівки у вторинному ареалі (в Житомирі) мають також теоретичне значення для з’ясування тенденцій зміни сезонних циклів мультивольтинних комах-фітофагів в умовах зміни клімату.
Ріст лісових культур сосни та дуба, створених різними видами садивного матеріалу, у Правобережному Лісостепу України
Authors: Василевський О. Г. , Єлісавенко Ю. А. , Тарнопільський П. Б. , Румянцев М. Г.
Published: August 2024

Наведено показники росту одно- і чотирирічних лісових культур дуба звичайного (Quercus robur L.) і сосни звичайної (Pinus sylvestris L.), створених різними видами садивного матеріалу. Дослідження проведено у лісовому фонді філій «Вінницьке ЛГ» (Вінницька область) та «Славутське ЛГ» (Хмельницька область) державного спеціалізованого господарського підприємства «Ліси України» (Подільський лісовий офіс). Виявлено, що одно- і чотирирічні лісові культури дуба звичайного і сосни звичайної, створені сіянцями із закритою кореневою системою, характеризувалися вищими висотою (на 6–18 %), приростом за висотою (на 7–34 %) та діаметром кореневої шийки (на 21–39 %), а також приживлюваністю (85–93 % проти 71 % для однорічних культур дуба та 93 % проти 86 % для однорічних культур сосни), порівнюючи з культурами, створеними сіянцями із відкритою кореневою системою. Результати досліджень доцільно використати під час розроблення рекомендацій щодо удосконалення технології створення лісових культур в умовах Правобережного Лісостепу України.
Підстилка як маркер антропотехногенних змін у соснових лісах рівнинної частини України
Authors: Ворон В. П. , Коваль І. М.
Published: August 2024

Виявлено особливості трансформації ланки «опад – підстилка» соснових лісостанів в умовах антропотехногенного забруднення та рекреації. Запас і структура лісової підстилки залежать від типу лісорослинних умов і віку насаджень. Через порушення екологічних умов уповільнюються процеси мінералізації фітодетриту. Унаслідок цього накопичується мортмаса, що відбивається на запасах, потужності та структурі підстилки. Так, у техногенній зоні період формування лісової підстилки збільшується на 0,9–3,0 року, а вміст важких металів у ній – у 3,4–5,5 разу, ніж за межами цієї зони. У міру збільшення рівня рекреаційного навантаження зменшується запас підстилки, а тривалість існування мортмаси в усіх підгоризонтах подовжується (різниця між сосняками першої та четвертої стадій рекреаційної дигресії становить один рік). Одержані дані свідчить про доцільність використання показників запасу, потужності та структури підстилки для індикації інтенсивності антропотехногенного впливу.
Post-pubertal presentation of 46XY disorders of sex development: A case report
Authors: Md. Shafiquzzaman  , Islam Md. Saiful , Islam Md. Nazrul
Published: August 2024

Not available
Control de emociones mediante estrategias psicopedagógicas dentro del aula
Authors: Pérez-Pérez Esteban , Alvarado-Quinto Roberto , Espinoza-Alvarez Edlita , Silva-Chávez Judith
Published: August 2024

El objetivo de esta investigación es analizar las emociones de los estudiantes y encontrar las mejores formas de manejar las emociones que afectan negativamente su desempeño en el aula utilizando técnicas psicopedagógicas. 15 estudiantes del primer año de bachillerato de la Unidad Educativa Juan León Mera "La Salle" en Ambato se evaluaron con el examen de inteligencia emocional de Goleman. En el primer trimestre de 2024 se realizó un estudio correlacional y no experimental. Los resultados muestran que una mayoría significativa de los estudiantes, hombres y mujeres, tienen dificultades para atender adecuadamente sus emociones, comprender sus estados emocionales y administrarlas eficazmente. Más del 55% de los hombres y el 66% de las mujeres necesitan prestar más atención a sus emociones. En cuanto a la claridad emocional, el 89 % de los hombres y el 83 % de las mujeres muestran deficiencias significativas, mientras que el 66 % de los hombres y el 50 % de las mujeres requieren mejoras en la capacidad de reparación emocional. Estos hallazgos sugieren que se requiere una intervención psicopedagógica que se centre en el desarrollo de habilidades emocionales fundamentales, la mejora de la autoconciencia emocional y la enseñanza de métodos de regulación emocional como la respiración consciente y la práctica de gratitud. Mejorar el manejo emocional de los estudiantes ayudará a mejorar el entorno de aprendizaje y el desarrollo personal de los estudiantes, lo que facilitará una interacción más saludable y cooperativa dentro del aula.
Enfoques psicopedagógicos para mejorar la atención en el contexto escolar
Authors: Baquerizo-Palacios Joselyn , Torres-Chiliquinga Luzmila , Chiluisa-Suntasig Jose , Castro-Acosta Washington
Published: August 2024

Este estudio titulado "Enfoques psicopedagógicos para mejorar la atención en el contexto escolar" aborda la problemática de la falta de intervenciones efectivas para estudiantes con dificultades de atención. Se basa en una exhaustiva revisión bibliográfica utilizando diversas bases de datos académicas, como Scopus, Web of Science y Google Scholar, resaltando la importancia de intervenciones tempranas y personalizadas. Se identifican obstáculos, como la falta de detección precoz y la limitación de recursos en el sistema educativo. La metodología empleada es descriptiva, utilizando una revisión bibliográfica sistemática que evalúa críticamente la calidad y pertinencia de los estudios seleccionados. Se destacan los factores ambientales y sociales que contribuyen a las dificultades de atención, así como la diversidad de tipos de atención y la eficacia de las intervenciones psicopedagógicas, enfrentándose a desafíos relacionados con la falta de recursos. En las conclusiones, se resalta la necesidad de abordar factores ambientales y sociales, implementar programas de detección precoz, invertir en la formación del profesorado y asignar recursos adecuados. Se sugiere un enfoque integral que involucre a educadores, instituciones educativas y responsables políticos para superar la falta de intervenciones psicopedagógicas y garantizar el máximo potencial académico y emocional de los estudiantes con dificultades de atención.
Swot Analysis For Determining The Company's Position In Business Sustainability
Authors: Muhammad Rafly  , Rini Rahayu Kurniati  , Ainul Chanafi
Published: August 2024

The purpose of this study is to analyze internal and external factors to determine the position of Tahu Sutra Presta Jaya MSME in business sustainability using SWOT analysis. This research method uses a mix method. Data collection techniques in this study through interviews, questionnaires, observation and documentation. Qualitative data analysis techniques use the Miles and Hubberman model while quantitative data analysis techniques use SWOT analysis. The results of this study indicate that the position of Tahu Sutra Presta Jaya MSME in the SWOT diagram is in quadrant I which supports an aggressive strategy. The strategies that can be applied in these conditions are the Strengths-Opportunities, SO strategy.
TINJAUAN KONSENTRASI HAMBATAN MINIMUM BEBERAPA TANAMAN TERHADAP Mycobacterium tuberculosis
Authors: Srivaliana Hilda , Viosepta Prasetya Ahmada , Keasa Maura Geasynova Aktha , Angelina Sitorus Joy , Nadira Putri Meira , Latifah Rahma Naila , Caroline Affandy Rosa , Sabila Salsa , Fitria Gunawan Sarah Nur , Habibah Siri
Published: August 2024

ABSTRAK
 
TBC adalah penyakit yang menjadi perhatian khusus global. Pada umumnya infeksi TB diobati dengan antibiotik seperti rifampisin, isoniazid, etambutol, streptomisin, dan pirazinamid. Namun, tingginya angka penyakit TBC di Indonesia dan dunia berbanding lurus dengan tingginya tingkat resistensi terhadap obat TBC yang dikenal dengan multidrug-resistant tuberculosis (MDR TB) sehingga diperlukan penemuan obat baru anti-tuberkulosis. Obat dari bahan alam dapat menjadi alternatif untuk pengobatan TB. Aktivitas tumbuhan sebagai anti-TB dapat diketahui dengan melihat nilai MIC (Minimum Inhibitory Concentration). Terdapat 13 tanaman yang diidentifikasi memiliki aktivitas anti TB yang diklasifikasikan berdasarkan nilai MIC. Didapatkan hasil 5 tanaman termasuk dalam kategori MIC yang sangat aktif, 7 aktif, dan 1  sedang.
 
Kata Kunci: Tuberkulosis, Mycrobacterium Tuberculosis, MIC
Pengaruh Variasi Media Pendingin Terhadap Kekerasan dan Mikrostruktur Pada Pengecoran Aluminium 6061
Authors: Sigit Kristiadi  , Unung Lesmanah  , Artono Raharjo
Published: August 2024

Proses pengecoran dan proses pendinginan pada logam dapat mempengaruhi sifat mekanis dan sifat fisik yang terbentuk. Perubahan pada sifat logam dipengaruhi oleh jenis dan media pendingin pada proses pendinginan logam. Penelitian ini bertujuan untuk mengetahui pengaruh dari perbedaan media pendingin (Air, Dromus, dan Coolant radiator) pada proses quenching terhadap kekerasan dan mikrostruktur pada Aluminium 6061 yang telah melewati tahap pengecoran. Didapatkan kesimpulan variasi media pendingin yang digunakan mempengaruhi tingkat kekerasan dan mikrostruktur benda uji yang berbeda-beda. Dari hasil pengujian didapatkan benda uji variasi media pendingin Air memiliki tingkat kekerasan tertinggi, ukuran butir terkecil, dan jumlah matriks α-Al yang terbentuk lebih rendah dibandingkan benda uji media pendingin Dromus. Benda uji dengan media pendingin Dromus memiliki tingkat kekerasan lebih tinggi, ukuran butir lebih kecil, dan jumlah matriks α-Al yang terbentuk lebih rendah dibandingkan benda uji media pendingin Coolant radiator yang memiliki tingkat kekerasan terendah, ukuran butir terbesar, dan jumlah matriks α-Al terbanyak.
Analisis Performa Pembangkit Listrik Panas Matahari Menggunakan Generator Termoelektrik
Authors: Abdurrasyid Faris , Margianto  , Nur Robbi
Published: August 2024

Di Indonesia, bahan bakar fosil yang tidak terbarukan digunakan untuk menghasilkan energi listrik yang berpotensi memberikan pengaruh terhadap lingkungan. Energi baru terbarukan diperlukan sebagai sumber energi untuk mengurangi konsumsi bahan bakar fosil. Panas matahari adalah salah satu sumber energi yang melimpah di Indonesia, dan generator termoelektrik dapat digunakan untuk memanfaatkannya. Generator termoelektrik dapat menghasilkan listrik dari energi panas matahari yang melimpah dan tidak merusak lingkungan dengan menggunakan kolektor surya di sisi panas dan heatsink di sisi dingin. Penelitian ini bertujuan untuk mengengetahui efisiensi generator termoelektrik, heatsink, kolektor surya dan efisiensi keseluruhan alat. Temuan penelitian ini menunjukkan bahwa keluaran energi yang diperoleh kolektor akibat variasi matahari mempengaruhi efisiensi kolektor surya pada sisi panas generator termoelektrik. Efisiensi heatsink yang terletak di sisi dingin generator termoelektrik berbanding terbalik dengan nilai panas dasarnya. Nilai perbedaan suhu pada sisi panas dan dingin generator termoelektrik berfluktuasi, yang mempengaruhi nilai efisiensi pada generator termoelektrik, sedangkan energi dan daya berguna yang dihasilkan oleh generator termoelektrik dapat mempengaruhi efisiensi sistem secara keseluruhan.
ANALISIS PENGARUH KOMPOSISI GARAM TERHADAP LAJU KOROSI PADA BAJA HSS
Authors: Jago Thomas Apriliano , Tsamroh Dewi Izzatus , Jumiadi  , Setyawan Pungky Eka
Published: August 2024

Korosi, yang merupakan proses rusaknya logam akibat faktor lingkungan seperti mikroba, pH, kelembapan, suhu, dan pencemar dari logam itu sendiri, memiliki sifat yang sangat merusak bagi logam. Sebelum mengimplementasikan metode pengendalian yang tepat, seringkali diperlukan pengujian untuk menentukan pendekatan yang sesuai. Salah satu metode pengujian yang berguna adalah tes kamar semprot, yang prinsip kerjanya melibatkan pembuatan kabut media pengkorosi pada sampel uji. Dalam penelitian ini, baja HSS digunakan sebagai sampel uji. Dengan menggunakan tes kamar semprot, air garam dengan berbagai komposisi dituangkan ke dalam wadah untuk menghasilkan kabut, yang dihasilkan oleh mist maker. Kabut tersebut kemudian didorong ke atas oleh kipas kecil dengan arus 12 v dan disemprotkan ke benda uji selama periode 8 hari. Alat ini bermanfaat untuk menentukan laju korosi dari logam yang diuji, memungkinkan penentuan seberapa cepat logam terkena korosi, yang berguna dalam pemilihan material untuk konstruksi yang sesuai dengan kondisi lingkungan. Berdasarkan hasil pengujian, dapat disimpulkan bahwa laju korosi pada baja HSS adalah 0,070 MPY dengan komposisi garam 500 gram, 0,072 MPY dengan komposisi garam 750 gram, 0,142 MPY dengan komposisi garam 1,250 gram, dan 0,162 MPY dengan komposisi garam 1,750 gram.
CRITICAL VALUE OF GLUCOSE USING CRITIVA 1.0 APPLICATION IN BALI MANDARA EYE HOSPITAL
Authors:   Department of Clinical Pathology Faculty of Medicine Udayana University, Dewi Pande Putu Ayu Patria , Ardhiana Dewa Putu Yudhi ,   STMIK STIKOM Indonesia Informatics Engineering Program, Putra I Dewa Putu Gede Wiyata ,   STMIK STIKOM Indonesia Computer System Program
Published: August 2024

Critical value is very critical result in laboratory examination that can indication several emergency conditions. Reporting critical values are controversial between hospital management, clinicians, and laboratory. Reporting critical value required effective communication. Information technology has become one of the solution effective communication in reporting critical values. Critical values can occur in clinical chemistry, hematology, and other laboratory examination. Glucose is one of the clinical chemistry parameters which is often foound critical value and therapy must be given immediately. Aim of this research is to evaluated time reporting using Critiva 1.0 application in cellular phone of clinical pathologist Bali Mandara Eye Hospital. Samples were 50 times reporting the glucose critical value simulation using the Critiva 1.0 application and 50 times reporting the Standard Operating Operations (SPO) simulation at the Bali Mandara Eye Hospital. Simulation carried by laboratory techonology in charge. We used means to analyze time reporting and SPSS version 16. Mean reporting glucose critical value using Critiva 1.0 application was 12 seconds. Mean reporting glucose critical value using SPO Bali Mandara Eye Hospital was 720 seconds.
Experiences of Muslim patients living with peritoneal dialysis: A qualitative study in Southern Thailand
Authors: Seephom Sunisa , Balthip Karnsunaphat , Jittanoon Piyanuch
Published: August 2024

Background: Living with peritoneal dialysis affects the patient’s life. The experiences of peritoneal dialysis patients, especially Muslim patients, are incomprehensible. There is a need to explore this area further to foster nursing practice improvement through enhanced understanding.
Objective: The purpose of this study was to understand the experiences of Muslim patients who are undergoing peritoneal dialysis.
Methods: A qualitative descriptive design was employed to gain a deeper understanding of the experiences of Muslim patients undergoing peritoneal dialysis in a peritoneal dialysis unit in Southern Thailand. Participants were initially recruited through purposive sampling and then selected based on the inclusion criteria. Data saturation was reached from October 2019 to January 2020. Ten Muslim patients who had been receiving peritoneal dialysis for a minimum of one month participated in personalized, in-depth, face-to-face interviews, which were supplemented by field notes. Inductive content analysis was performed using open coding, categories, and abstractions.
Results: The experiences of Muslim patients undergoing peritoneal dialysis were grouped into two main categories: 1) Overwhelmed by change and 2) Learned to survive.
Conclusion: Peritoneal dialysis has a significant impact on Muslim patients, especially during the first months of treatment. Recognizing religious teachings and strengthening religious commitment through participation in religious practices are central to living on peritoneal dialysis. The findings offer a more profound insight into the experiences of Muslim patients receiving peritoneal dialysis. These results can be foundational knowledge for establishing and improving culturally appropriate nursing practices for Muslim patients.
Experiences of Indonesian women with breast cancer underwent treatment decision-making: A qualitative study
Authors: Sitanggang Yenni Ferawati , Lin Hung-Ru
Published: August 2024

Background: Patients with breast cancer face a complex situation upon receiving their diagnosis and considering future treatment options. In Indonesian culture, relatives and others significantly influence decision-making processes. Understanding the perspectives of Indonesian women with breast cancer regarding treatment decision-making can enhance satisfaction with the care provided.
Objective: This study aimed to explore the experiences of Indonesian women with breast cancer regarding treatment decision-making.
Methods: A qualitative descriptive study design was utilized. Purposive sampling was employed to select the study participants. In-depth interviews were conducted with 15 women with breast cancer between March and June 2023. The data were analyzed using thematic analysis.
Results:  Three main themes were developed: 1) Emotional impact and uncertainty in cancer care, 2) Clear communication and support for patients, and 3) Family-centered decision-making in treatment planning.
Conclusion: This study highlights the perspectives of Indonesian women with breast cancer on treatment decision-making. Nurses play a crucial role in providing clear information to patients and their families during the decision-making process. Understanding the experiences of women with breast cancer can help support and empower patients through effective communication while they undergo treatment.
Adherence to treatment in pulmonary tuberculosis: Rodgers’ evolutionary concept analysis
Authors: Prasetyo Yunus Adhy , Thanasilp Sureeporn , Preechawong Sunida
Published: August 2024

Background: Adherence to treatment is essential for the management of pulmonary tuberculosis. Nurses and healthcare professionals play a significant role in promoting adherence behavior among this population. Nevertheless, defining adherence to treatment within this particular population remains complex.
Objective: This study aimed to explore and clarify the concept of adherence to treatment among individuals with pulmonary tuberculosis.
Methods: Rodgers’ evolutionary concept analysis was employed in this study. A literature search was conducted in the PubMed and Scopus databases to identify relevant studies published between July 2013 and July 2023.
Results: The attributes of adherence to treatment in pulmonary tuberculosis consist of multiple components: biological, individual, social, health service, and policy-making processes. Antecedents include various patient-related factors as well as factors associated with clinical conditions and patient-health professional engagement. Three consequences of the concept have emerged: enhanced treatment efficacy, increased commitment to tuberculosis treatment adherence, and improved health service quality.
Conclusion: This study provides a comprehensive operational definition of adherence to tuberculosis treatment, including its attributes, antecedents, and consequences. This framework will assist nurses in evaluating adherence more effectively. However, further research into the experiences of individuals adhering to tuberculosis treatment is needed to confirm and enhance these strategies.
Totalitarianism in Yoko Ogawa's The Memory Police
Authors: Cahyaningtyas Lintang , Wahyono Danu
Published: August 2024

This study discusses about totalitarianism in Yoko Ogawaâ€™s The Memory Police. There are four question to be answered in this research: the depiction of totalitarianism in the novel, the cause and effects of totalitarianism in the novel, and the charactersâ€™ resistance to totalitarianism in the novel. The objective of the study is to find the reflection of totalitarianism on islanders, the depicted cause of totalitarianism, the depicted effects of totalitarianism, and the charactersâ€™ resistance to totalitarianism. In analyzing the problem, the writer applies a descriptive qualitative method with sociological approach. The analysis shows the forms of totalitarianism found are terror, absolute control, surveillance, and monopolizing information. The effects of totalitarianism found are loss of trust, intolerance, loss of identity, fear and anxiety, loneliness and isolation, emptiness, trauma and depression. Most of the people calmly accept the reality of the loss of memories, but some fight back. The charactersâ€™ resistance to totalitarianism found are forming groups, escaping, and making a hiding place. The writer concludes that the Memory Police as a totalitarian government body uses their repressive power to impose forgetfulness and create an oppressive atmosphere. Because of their repressive power, there are many negative effects on the islanders.
TARIKAN PERJALANAN WISATAWAN DI EMPAT GEOSITE PADA KAWASAN GEOPARK BAYAH DOME KABUPATEN LEBAK TAHUN 2030
Authors: NURDIYATMI HUDA EKA , DJAKAPERMANA RUCHAT DENI , ARTININGSIH TITIK PENTA
Published: August 2024

Potensi wisata di Kabupaten Lebak sangatlah beragam dan masih banyak potensi yang bisa dikembangkan. Salah satunya adalah Kawasan Geopark Bayah Dome yang memiliki 32 geosite yang tersebar di 10 kecamatan. Dari 32 geosite yang ada empat diantaranya berpotensi untuk dikunjungi wisatawan dan memiliki nilai geologi, nilai budaya dan nilai keberlanjutan tinggi.  Adapun goesite yang memiliki nilai-nilai tersebut adalah Pantai Tanjung Layar, Pantai Karangbokor, Gunung Luhur dan Curug Ciporolak. Tentunya jika ingin mengembangkan sektor pariwisata ini dibutuhkan sektor pendukung agar bisa bersinergi, yaitu sektor transportasi. Penyediaan transportasi yang ada saat ini Kabupaten Lebak belum bisa menjangkau keempat geosite ini secara efektif dan efesien. Untuk menyediakan sistem transportasi tersebut, maka dibutuhkan jumlah tarikan wisatawan yang direncanakan untuk jangka waktu menengah. Oleh karena itu penulisan jurnal ini bertujuan untuk menganalisis besaran intesitas trip attraction atau tarikan perjalanan wisatawan pada Pantai Tanjung Layar, Pantai Karangbokor, Gunung Luhur dan Curug Ciporolak. Model yang digunakan dalam penelitian ini model potensi gravitasi dengan menggunakan Drew’s technique. Hasil penelitian ini adalah daya tarik perjalanan tertinggi yaitu di Tanjung Layar–Karang Bokor adalah 321.390.119 perjalanan orang atau 46, 06% pada tahun 2030, Kata Kunci: Transportasi, Tarikan Perjalanan Wisatawan ABSTRACT The tourism potential in Lebak Regency is very diverse and there is still a lot of potential that can be developed. One of them is the Bayah Dome Geopark Area, which has 32 sites spread over 10 districts. Of the 32 sites, four of them have the potential to be visited by tourists and have high geological, cultural, and sustainability values. The sites that have these values are Tanjung Layar Beach, Karangbokor Beach, Mount Luhur, and Ciporolak Waterfall. Of course, if you want to develop the tourism sector, a supporting needed sector that it can synergize, with namely the transportation sector. The current transportation provision for Lebak Regency has not been able to reach these four geosites effectively and efficiently. To provide this transportation system, it is necessary to attract several tourists planned for the medium term. Therefore writing this journal aims to analyze the magnitude of the intensity of the trip attraction or the attraction of tourist trips at Tanjung Layar Beach, Karangbokor Beach, Mount Luhur, and Ciporolak Waterfall. The model used in this study is the gravitational potential model using Drew’s Technique. The results of this study are that the highest travel attraction is in Tanjung Layar–Karang Bokor with 321,390,119 trips or 46.06% in 2030. Keywords: Transportation, Attraction of Tourist Travels
ANALISIS KADAR AIR DAN KADAR HMF PADA MADU HUTAN (Apis dorsata Binghami) DI KECAMATAN ASINUA KABUPATEN KONAWE
Authors: Pujirahayu Niken , Uslinawaty Zakiah , Hadjar Nurhayati
Published: August 2024

Penelitian ini bertujuan untuk mengetahui kadar Air dan Kadar HMF madu hutan Apis dorsata binghamii dari Kecamatan Asinua, Konawe. Penelitian ini dilakukan dalam tiga tahap, yaitu tahap preparasi sampel, tahap ekstraksi, dan tahap pengujian. Penyiapan sampel dilakukan di Laboratorium Kehutanan Universitas Halu Oleo, Ekstraksi dilakukan di laboratorium mikrobiologi BPOM Kendari dan Laboratorium Biokimia FMIPA Universitas Hasanuddin. Pengujian madu hutan Apis dorsata mengikuti Standar Nasional Indonesia (SNI) 8664-2018, meliputi kadar air dan kadar HMF dan uji organoleptik bau, rasa dan warna. Hasil penelitian menunjukkan bahwa kadar air madu sebesar 15,18 %b/b dan kadar HMF tidak terdeteksi, sedangkan sifat fisik warna, bau dan rasa menunjukkan sifat khas madu, hasil pengujian ini memenuhi persyaratan SNI 8664- 2018.
Model Matematika SEIR Pada Penyakit Diabetes Mellitus Tipe 2
Authors: Nurazizah Siti , Sani Asrul , Kabil Djafar Muhammad , Somayasa Wayan , La Gubu
Published: August 2024

Diabetes mellitus adalah penyakit metabolisme karbohidrat, protein dan lemak yang tidak normal. Penyakit ini disebabkan oleh kurangnya sensitivitas otot dan jaringan terhadap insulin, yang disebut resistensi insulin, atau kekurangan hormon insulin. Diabetes mellitus tipe 2, pankreas masih dapat membuat insulin, tetapi insulin tersebut berkualitas buruk dan tidak dapat berfungsi dengan baik. Penelitian ini bertujuan untuk membahas model epidemik  untuk penyakit diabetes mellitus tipe 2. Dari hasil analisis model  diperoleh dua titik kesetimbangan yaitu titik kesetimbangan bebas penyakit dan titik kesetimbangan endemik. Analisis kestabilan titik kesetimbangan bebas penyakit menggunakan linearisasi disekitar titik kesetimbangan. Untuk mencari bilangan reproduksi dasar juga dilakukan dengan metode matriks generasi selanjutnya. Hasilnya, titik kesetimbangan bebas penyakit stabil asimtotik jika bilangan reproduksi dasar kurang dari satu, artinya penyakit akan menghilang setelah jangka waktu tertentu, sedangkan titik kesetimbangan endemik stabil jika bilangan reproduksi dasar lebih dari satu, artinya penyakit akan tetap ada. Simulasi numerik model untuk penyakit diabetes mellitus tipe 2 yang dilakukan sejalan dengan analisis perilaku model.
UJI GOODNESS OF FIT UNTUK DISTRIBUSI GEOMETRIK MENGGUNAKAN UJI STATISTIK KOLMOGOROV-SMIRNOV
Authors: Amelia Reski , Somayasa Wayan , Alfian  , Ruslan
Published: August 2024

Penelitian ini bertujuan untuk mengevaluasi kecocokan distribusi geometrik dengan data lemparan bola basket. Estimasi parameter ( ) distribusi geometrik dengan metode MLE diperoleh dengan persamaan . Ketakbiasan penduga MLE diuji dengan membandingakn nilai variansi dan nilai BBCR, diperoleh nilai var  sehingga  bukan merupakn UMVUE. Hasil analisis statistik menggunakan uji Kolmogorov-Smirnov menunjukkan bahwa data tersebut mengikuti distribusi geometrik dengan parameter ​ . Statistik uji Kolmogorov-Smirnov  = 4,0135 lebih besar dari nilai tabel kuantil-kuantil = 0,3667 pada tingkat signifikansi α = 0,05 untuk n = 25. Oleh karena itu, hipotesis nol yang menyatakan bahwa data mengikuti distribusi geometrik diterima, menunjukkan kesesuaian yang signifikan antara distribusi geometrik yang diasumsikan dan distribusi sebenarnya dari data lemparan bola basket.
Fermat' s Last Theorem
Authors: Muhammad Taha
Published: August 2024

Abstract of Fermat’s Last Theorem proof I relate Fermat's Last Theorem to the three-dimensional geometric shapes of triangles and three sides that do not form a triangle. These geometric shapes represent all positive natural numbers. I did prove in every shape that Fermat's Last Theorem is wrong. The whole proofs are on approximately five pages long (11 in X 8 in).
Atomic insights into the competitive edge of nanosheets splitting water
Authors: Falling Lorenz , Jang Woosun , Laha Sourav , Götsch Thomas , Terban Maxwell , Mom Rik , Velasco-Vélez Juan-Jesús , Girgsdies Frank , Teschner Detre , Tarasov Andrey , Chuang Cheng-Hao , Lunkenbein Thomas , Knop-Gericke Axel , Weber Daniel , Dinnebier Robert , Lotsch Bettina , Schlögl Robert , Jones Travis
Published: August 2024

The oxygen evolution reaction (OER) provides the protons for many electrocatalytic power-to-X processes, such as the production of green hydrogen from water or methanol from CO2. Iridium oxo-hydroxides (IOHs) are outstanding catalysts for this reaction because they strike a unique balance between activity and stability in acidic electrolytes. Within IOHs, this balance varies with atomic structure. While amorphous IOHs perform best, they are least stable. The opposite is true for their crystalline counterparts. These rules-of-thumb are used to reduce the loading of scarce IOH catalysts and retain performance. However, it is not fully understood how activity and stability are related on the atomic level, hampering rational design. Herein, we provide simple design-rules (Figure 12) derived from literature and various IOHs within this study. We chose crystalline IrOOH nanosheets as our lead material because they provide excellent catalyst utilization and a predictable structure. We found that nanosheets combine the chemical stability of crystalline IOHs with the activity amorphous IOHs. Their dense bonding network of pyramidal trivalent oxygens (μ3∆–O) provides structural integrity, while allowing reversible reduction to an electronically gapped state that diminishes the destructive effect of reductive potentials. The reactivity originates from coordinative unsaturated edge sites with radical character, i.e. μ1–O oxyls. By comparing to other IOHs and literature, we generalized our findings and synthesized a set of simple rules that allow prediction of stability and reactivity of IOHs from atomistic models. We hope that these rules will inspire atomic design strategies for future OER catalysts.
Understanding the role of miRNAs in cervical cancer pathogenesis and therapeutic responses
Authors: Chauhan Prashant , Pramodh Sreepoorna , Hussain Arif , Elsori Deena , Lakhanpal Sorabh , Kumar Rahul , Alsaweed Mohammed , Iqbal Danish , Pandey Pratibha , Al Othaim Ayoub , Khan Fahad
Published: August 2024

Cervical cancer (CC) is the most common cancer in women and poses a serious threat to health. Despite familiarity with the factors affecting its etiology, initiation, progression, treatment strategies, and even resistance to therapy, it is considered a significant problem for women. However, several factors have greatly affected the previous aspects of CC progression and treatment in recent decades. miRNAs are short non-coding RNA sequences that regulate gene expression by inhibiting translation of the target mRNA. miRNAs play a crucial role in CC pathogenesis by promoting cancer stem cell (CSC) proliferation, postponing apoptosis, continuing the cell cycle, and promoting invasion, angiogenesis, and metastasis. Similarly, miRNAs influence important CC-related molecular pathways, such as the PI3K/AKT/mTOR signaling pathway, Wnt/β-catenin system, JAK/STAT signaling pathway, and MAPK signaling pathway. Moreover, miRNAs affect the response of CC patients to chemotherapy and radiotherapy. Consequently, this review aims to provide an acquainted summary of onco miRNAs and tumor suppressor (TS) miRNAs and their potential role in CC pathogenesis and therapy responses by focusing on the molecular pathways that drive them.
Innovative nomogram for predicting 1-year clinically driven revascularization outcomes in endovascular femoropopliteal disease
Authors: Pan Dikang , Wu Sensen , Wang Hui , Ning Yachan , Guo Jianming , Wang Cong , Guo Lianrui , Sang Hongfei , Gu Yongquan
Published: August 2024

Purpose

Femoropopliteal artery disease (FPAD) is a common vascular disease that usually requires surgical treatment. The aim of this study was to apply predictive modeling to develop predictive models for predicting clinically driven target revascularization (CD-TLR) events 1 year after intervention in patients with FPAD.

Materials and methods

In this study, clinical data were collected from a total of 484 patients who underwent FPAD endovascular intervention from 2014 to 2019. According to the inclusion and exclusion criteria, 400 patients will be finally included and assigned to the training cohort and test cohort in the ratio of 7:3. By analyzing these data through statistical methods, we will explore the effects of different factors on target revascularization events 1 year after intervention in FPAD patients, and build the corresponding prediction model of the column line graph.

Results

The final nomogram model consisted of 5 independent predictors: history of cerebrovascular disease, lesion length >15 cm, no atherectomy device used, no medicated balloon used and procedure time. The C-index of the model was 0.766 and 0.726 for the training cohort and validation cohort, respectively. The calibration curves also showed that the model had satisfactory agreement in both cohorts.

Conclusions

The newly developed prediction model can accurately predict clinically driven target revascularization events at 1 year in patients with FPAD, providing valuable information for the development of individualized treatment plans.
Prediction of hydrogen consumption scale and hydrogen price based on LEAP model and two-factor learning curve
Authors: Li Hongxia , Yu Haiguo , Wang Haiting , Gou Xiaokan , Liu Fei , Li Lixin , Wang Qian , Zhang Xin , Li Yuanyuan
Published: August 2024

Under the dual-carbon target, hydrogen energy, as a zero-carbon secondary energy source, has great scope for replacing fossil feedstocks in the fields of energy, transportation and industry. However, the current research on the competitiveness of hydrogen energy in various fields is not sufficiently addressed. In this paper, we use the LEAP model to predict the future scale of hydrogen use and the two-factor learning curve to predict the trend of hydrogen price change from 2025 to 2050, using Qinghai Province as the research background. At the same time, considering the carbon emission reduction benefits and raw material costs, the competitiveness of hydrogen energy in energy, transportation, industry and other fields in the future is compared. The results show that: 1) The hydrogen load scale in Qinghai Province will grow fast from 2025 to 2030. From 2030 to 2040, it slows under the steady and basic scenarios but remains high under the accelerated one. By 2040, the consumption scales are 1.057 million, 649,000 and 442,000 tons respectively. 2) The price of hydrogen energy will drop rapidly from the current 28 CNY/kg to about 20 CNY/kg in the next 5 years. By 2040, the price of hydrogen energy will be reduced to about 17 CNY/kg. 3) In terms of hydrogen energy competitiveness, when carbon emissions are not taken into account, hydrogen energy is currently competitive in the transportation field. During 2032–2038, it will be competitive in the field of methanol synthesis. By 2040, hydrogen energy will not be competitive in the fields of ammonia synthesis and power/heating. When considering carbon emissions, the competitiveness of hydrogen energy in the transportation field will become greater. The competitive year in the field of methanol synthesis will be 1–2 years ahead. By 2040, it will not be competitive in the field of synthetic ammonia and power/heating, but the gap will be significantly reduced due to the consideration of carbon emissions.
Effect of different single and combined antihypertensive drug regimens on the mortality of critical care patients
Authors: Fang Yipeng , Huang Xianxi , Shi Junyu , Ren Chunhong , Zhang Xin
Published: August 2024

Objective

To investigate the effect of different single and combined pre-admission antihypertensive drug regimens on the prognosis of critically ill patients.

Methods

We performed a retrospective cohort study using data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. All initial ICU admission records of patients with hypertension and previous antihypertensive exposure before ICU admission were included. Our primary outcome was 90-day mortality. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to balance the distribution of baseline characteristics. Logistic regression analysis and subgroup analysis were performed to determine the independent effect of different single and combined antihypertensive drug regimens on 90-day mortality.

Results

A total of 13,142 patients were included in the final analysis. The 90-day mortality rate in the combined groups is lower than that in the single therapy group (10.94% vs 11.12%), but no statistical significance was found in the original cohort (p = 0.742). After adjustment for potential confounders, the significantly decreased 90-day mortality rate was found in the combined groups (10.78% vs 12.65%, p = 0.004 in PSM; 10.34% vs 11.90%, p = 0.007). Patients who were exposed to either ACEIs or ARBs had a better prognosis than those not exposed (7.19% vs 17.08%, p < 0.001 in single antihypertensive groups; 8.14% vs18.91%, p < 0.001 in combined antihypertensive groups). The results keep robustness in the PSM and IPTW cohorts. In the logistic regression model analysis, combined therapy was associated with a 12%–20% reduced risk of 90-day death after adjusting potential confounders (OR 0.80–0.88, all p < 0.05), while exposure to ACEIs or ARBs was associated with the decreased risk of 90-day death by 52%–62% (OR 0.38–0.48, all p < 0.001) and 40%–62% (OR 0.38–0.60, all p < 0.001) in the single and combined therapy groups, respectively. The results were still robust to subgroup analysis.

Conclusions

Pre-admission combined antihypertensive therapy is associated with a significantly lower risk of death than exposure to single antihypertensives in critically ill patients. Meanwhile, either ACEIs or ARBs seem to be the optimal candidates for both single and combined therapy. Further high-quality trials are needed to confirm our findings.
Comparison of lidocaine bicarbonate with fentanyl and chloroprocaine for epidural anesthesia during cesarean section: a randomized, controlled, double-blind clinical trial
Authors: Yu Jing , Liu Jingjing , Wang Chenran , Song Congzhong , He Gangming , Liu Chaohui , Mei Zhong , Huang Shaoqiang
Published: August 2024

Chloroprocaine and lidocaine bicarbonate are commonly used for epidural anesthesia because of their rapid onset, particularly in the case of conversion from epidural labor analgesia to emergency cesarean section. However, it is unclear whether lidocaine bicarbonate combined with fentanyl has an advantage over chloroprocaine alone in emergency cesarean section. In this study, 102 women who underwent elective cesarean section received 15 mL 3% chloroprocaine and 1 mL saline (CP group) or 15 mL 1.73% lidocaine bicarbonate and 1 mL fentanyl 50 μg (LF group) for epidural anesthesia. Nociceptive block level was assessed by pinprick and recorded every minute. The primary outcome was the onset time to T6 block. The median onset time to T6 analgesia was 10 [10, 10] min in the CP group and 10 [7, 10] min in the LF group (COX model for CP versus LF, HR 0.47, 95% CI 0.23–0.95, p = 0.035). The median onset time to T8 analgesia was 7 [5, 9] min in CP group and 5 [4, 7] min in LF group (COX model for CP versus LF, HR 0.61, 95% CI 0.39–0.95, p = 0.027). The proportion of hypotension episodes occurring before delivery in LF group was lower than that in CP group (p = 0.011). The incidence of block level ≥ T4 after supplemental dosing in the LF group was lower than that in the CP group (p = 0.031). Compared with 3% chloroprocaine, 1.73% lidocaine bicarbonate combined with fentanyl 50 μg has a slightly faster onset time and less hypotension in epidural anesthesia for cesarean section.

Clinical Trial Registration:http://www.chictr.org.cn/index.html, identifier ChiCTR2200056180.
Sedative and anxiolytic effects of Capparis sicula Duhamel: in vivo and in silico approaches with phytochemical profiling
Authors: Karpuz Ağören Büşra , Küpeli Akkol Esra , Çelik Ismail , Sobarzo-Sánchez Eduardo
Published: August 2024

The World Health Organization reports that 30% of adults worldwide suffer from insomnia, while 10% of people worldwide suffer with various forms of anxiety. The significant negative effects of conventional medications used to treat anxiety and insomnia, such as abuse, addiction, amnesia, and cognitive and sexual dysfunction, have led to an increased preference for naturally derived substances with fewer side effects. Accordingly, in this study, the sedative and anxiolytic effects of n-hexane, ethyl acetate (EtOAc), methanol (MeOH) and water extracts of the aerial parts of Capparis sicula Duhamel., which is used for sedative purposes in folk medicine, were evaluated. To evaluate the sedative and anxiolytic effects of each extract, bioassay systems were used including traction and hole-board tests. The MeOH extract of C. sicula was the most active extract on in vivo traction and hole-board tests compared to Diazepam. From the MeOH extract, major components were isolated, and their structures were identified as three flavonoid glycosides [rutin (1), quercetin-3-O-glucoside (2), and quercetin 3-O-rhamnoside (3)] using spectral techniques. The most abundant component was determined to be rutin, comprising 8 mg/100 mg dry extract in MeOH extract and 76.7 mg/100 mg dry fraction in fraction C using HPLC. The molecular docking studies evaluated the interaction of isolated flavonoid glycosides with the interaction energies and protein-ligand interaction details of the anxiety-related receptors GABAA and GABAB. For the GABAA receptor, quercetin-3-O-glucoside demonstrated the highest docking score. Quercetin-3-O-rhamnoside and rutin also show promising interactions, particularly with the GABAB receptor, highlighting their potential as modulators of these receptors. In conclusion, the use of C. sicula for sedative purposes in folk medicine has been confirmed for the first time by in vivo studies, and its possible active compounds and sedative-anxiolytic mechanism have been determined through phytochemical and in silico studies.
Sequential recruitment of body fluid spaces for increasing volumes of crystalloid fluid
Authors: Hahn Robert G.
Published: August 2024

Introduction

The interstitial space harbours two fluid compartments linked serially to the plasma. This study explores conditions that lead to fluid accumulation in the most secluded compartment, termed the “third space”.

Methods

Retrospective data was collected from 326 experiments in which intravenous crystalloid fluid was administered to conscious volunteers as well as a small group of anaesthetized patients. The urinary excretion and plasma dilution derived from haemoglobin served as input variables in nine population volume kinetic analyses representing subtly different settings.

Results

An infusion of 250–500 mL of Ringer’s solution expanded only the central fluid space (plasma), whereas the infusion of 500–1,000 mL extended into a rapidly exchanging interstitial fluid space. When more than 1 L was infused over 30 min, it was distributed across plasma and both interstitial fluid compartments. The remote space, characterized by slow turnover, abruptly accommodated fluid upon accumulation of 700–800 mL in the rapidly exchanging space, equivalent to an 11%–13% volume increase. However, larger expansion was necessary to trigger this event in a perioperative setting. The plasma half-life of crystalloid fluid was 25 times longer when 2,000–2,700 mL expanded all three fluid compartments compared to when only 250–500 mL expanded the central space (14 h versus 30 min).

Conclusion

As the volume of crystalloid fluid increases, it apparently occupies a larger proportion of the interstitial space. When more than 1 L is administered at a high rate, there is expansion of a remote “third space”, which considerably extends the intravascular half-life.