bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing Supply Chain Agility and Sustainability through Machine Learning: Optimization Techniques for Logistics and Inventory Management
Authors: Pasupuleti Vikram , Thuraka Bharadwaj , Kodete Chandra Shikhi , Malisetty Saiteja
Published: July 2024

Background: In the current global market, supply chains are increasingly complex, necessitating agile and sustainable management strategies. Traditional analytical methods often fall short in addressing these challenges, creating a need for more advanced approaches. Methods: This study leverages advanced machine learning (ML) techniques to enhance logistics and inventory man-agement. Using historical data from a multinational retail corporation, including sales, inventory levels, order fulfillment rates, and operational costs, we applied a variety of ML algorithms, in-cluding regression, classification, clustering, and time series analysis. Results: The application of these ML models resulted in significant improvements across key operational areas. We achieved a 15% increase in demand forecasting accuracy, a 10% reduction in overstock and stockouts, and a 95% accuracy in predicting order fulfillment timelines. Additionally, the approach identified at-risk shipments and enabled customer segmentation based on delivery preferences, leading to more personalized service offerings. Conclusions: Our evaluation demonstrates the transforma-tive potential of ML in making supply chain operations more responsive and data-driven. The study underscores the importance of adopting advanced technologies to enhance deci-sion-making, evidenced by a 12% improvement in lead time efficiency, a silhouette coefficient of 0.75 for clustering, and an 8% reduction in replenishment errors.
Progress on Material Design and Device Fabrication via Coupling Photothermal Effect with Thermoelectric Effect
Authors: Liu Shuang , Huo Bingchen , Guo Cun-Yue
Published: July 2024

Recovery and utilization of low-grade thermal energy is a topic of universal importance in today’s society. Photothermal conversion materials can convert light energy into heat energy, which can now be used in cancer treatment, seawater purification, etc., while thermoelectric materials can convert heat energy into electricity, which can now be used in flexible electronics, localized cooling, and sensors. Photothermoelectrics based on the photothermal effect and the Seebeck effect provide suitable solutions for the development of clean energy and energy harvesting. The aim of this paper is to provide an overview of recent developments in photothermal, thermoelectric, and, most importantly, photothermal–thermoelectric coupling materials. First, the research progress and applications of photothermal and thermoelectric materials are introduced, respectively. After that, the classification of different application areas of materials coupling photothermal effect with thermoelectric effect, such as sensors, thermoelectric batteries, wearable devices, and multi-effect devices, is reviewed. Meanwhile, the potential applications and challenges to be overcome for future development are presented, which are of great reference value in waste heat recovery as well as solar energy resource utilization and are of great significance for the sustainable development of society. Finally, the challenges of photothermoelectric materials as well as their future development are summarized.
Influence of Bio-Additives on Recycled Asphalt Pavements
Authors: D’Addio Giuseppe , Oreto Cristina , Viscione Nunzio , Veropalumbo Rosa
Published: July 2024

The construction and maintenance of asphalt pavements is a resource-consuming sector, where the continuous rehabilitation of the superficial layers demands large volumes of non-renewable resources. The present work focuses on the design and characterization of asphalt mixtures for the binder layer of an asphalt pavement containing 50% reclaimed asphalt (RAP), in which seven different bio-based additives, identified as R1A, R1C, R2A, R2B, R2C, R3A, and R3B, were added to improve the workability, strength, and stiffness properties. The experimental program envisioned the hot mixing of aggregates and RAP with either a 50/70 or a 70/100 bitumen and, in turn, each of the seven bio-additives. The asphalt mixtures underwent the characterization of their densification properties; air voids; indirect tensile strength (ITS); indirect tensile stiffness modulus at 10, 20, 40, and 60 °C; and rutting resistance at 60 °C. The results highlighted that the performance in terms of workability and ITS of the resulting mixtures depends on the type of bio-additive and largely on the fresh bitumen type, while the stiffness at high temperature is not significantly affected by the presence of the bio-additives.
Pulsed Magnetic Field Treatment Effects on Undissolved Carbides in Continuous Casting Billets of GCr15 Bearing Steel
Authors: Shen Lijuan , Lang Ruiqing , Xing Shuqing , Ma Yonglin
Published: July 2024

The study investigates the effect of pulsed magnetic fields on undissolved carbides in high-carbon chromium bearing steel GCr15 billets. The billets were subjected to heat treatment at 950 °C, with a pulsed magnetic field of varying durations applied during the process. The influence of the pulsed magnetic field on the distribution of undissolved carbides within the billets was investigated, and the thermodynamic and kinetic mechanisms of undissolved carbides dissolution were explored. The results indicate that the area percentage of undissolved carbides in the microstructure decreases from 1.68% to 0.06% after applying a pulsed magnetic field for 10 min, and the size of undissolved carbides decreases from 17.5 μm to 4.9 μm. When a pulsed magnetic field is applied for 30 min, all undissolved carbides dissolve. The statistics demonstrate that the average size of undissolved carbides is reduced from 14.19 μm to 0.63 μm, with a reduction percentage reaching 96%. Over the same duration, the number density of the undissolved carbides decreases from (0.19~0.55)/mm2 to (0.03~0.1)/mm2, and the percentage area of the undissolved carbides decreases from (1.26~1.68)% to (0~0.02)%. Thermodynamically, applying a pulsed magnetic field lowers the dissolution energy barrier of undissolved carbides and modifies their transformation temperature. Kinetically, the rate of alloy element diffusion is enhanced by increasing the frequency of atomic jumps. This research aims to provide new insights into enhancing the contact fatigue life of bearing steel, increasing the proportion of special steel, and optimizing the steel deep-processing process.
Optimization of Billet Cooling after Continuous Casting Using Genetic Programming—Industrial Study
Authors: Kovačič Miha , Zupanc Aljaž , Vertnik Robert , Župerl Uroš
Published: July 2024

ŠTORE STEEL Ltd. is one of the three steel plants in Slovenia. Continuous cast 180 mm × 180 mm billets can undergo cooling to room temperature using a turnover cooling bed. They can also be cooled down under hoods or heat treated to reduce residual stresses. Additional operations of heat treatment from 36 h up to 72 h and cooling of the billets for 24 h, with limited capacities (with only two heat treatment furnaces and only six hoods), drastically influence productivity. Accordingly, the casting must be carefully planned (i.e., the main thing is casting in sequences), while the internal quality of the billets (i.e., the occurrence of inner defects) may be compromised. Also, the stock of billets can increase dramatically. As a result, it was necessary to consider the abandoning of cooling under hoods and heat treatment of billets. Based on the collected scrap data after ultrasonic examination of rolled bars, linear regression and genetic programming were used for prediction of the occurrence of inner defects. Based on modeling results, cooling under hoods and heat treatment of billets were abandoned at the casting of several steel grades. Accordingly, the casting sequences increased, and the stock of billets decreased drastically while the internal quality of the rolled bars remained the same.
Small RNA and Freeze Survival: The Cryoprotective Functions of MicroRNA in the Frozen Muscle Tissue of the Grey Tree Frog
Authors: Rehman Saif , Storey Kenneth B.
Published: July 2024

The grey tree frog, Dryophytes versicolor, survives whole-body freezing for weeks during cold winter months. Survival in a state devoid of available food, water, or oxygen forces a reliance on metabolic rate depression (MRD) and the reprioritization of bodily functions. This study utilizes next-generation sequencing (NGS) and bioinformatic analyses to characterize changes in the microRNAome of D. versicolor. When comparing control to frozen groups, five microRNAs (miRNA) were found to be differentially regulated (miR-143-3p, miR-30e-3p, miR-10a-5p, miR-140-3p, and miR-148a-3p), suggesting that they play key roles in freeze survival. The KEGG and GO analyses of these changes predicted a significant negative enrichment of terms associated with cell proliferation and active metabolism while simultaneously predicting the upregulation of cell signalling terms. These results suggest a fast-acting regulatory role for miRNA in contributing to the reorganization of gene expression and the limitation of energy-expensive processes during MRD in the hind leg skeletal muscle of the frog.
Geochronology, Geochemical Characterization and Tectonic Background of Volcanic Rocks of the Longjiang Formation in the Lengjimanda Plate Area, Middle Da Hinggan Mountains
Authors: Wang Shi-Chang , Hao Yu-Jie , Shi Lu , Tang Zhen , Zhu Shuang
Published: July 2024

The Lengjimanda plate is situated in the middle section of the Da Hinggan mountains, in the eastern section of the Tianshan Xingmeng orogenic belt. To determine the formation age of the volcanic rocks in the Longjiang formation in this area, to explore their origin and tectonic background, and to reconstruct the geodynamic evolution of the region, this study conducted petrological, zircon U–Pb geochronological, geochemical, and isotopic analyses of the volcanic rocks in the Longjiang formation. The Longjiang formation’s volcanic rocks are primarily composed of trachyandesite, trachyte trachydacite, and andesite, which are intermediate basic volcanic rocks. They are enriched in large-ion lithophile elements, are depleted in high-field-strength elements, are significantly fractionated between light and heavy rare earth elements, and exhibit a moderate negative Eu anomaly in most samples. The results of the LA–ICP–MS zircon U–Pb dating indicate that the volcanic rocks in this group were formed in the Early Cretaceous period at 129.1 ± 0.82 Ma. The zircon εHf(t) ranges from +1.13 to +43.77, the tDM2 ranges from +655 to +1427 Ma, the initial Sr ratio (87Sr/86Sr)i ranges from 0.7030 to 0.7036, and the εNd(t) ranges from +2.1 to +6.6. Based on the geochemical compositions and isotopic characteristics of the rocks, the initial magma of the volcanic rocks in the Longjiang formation originated from the partial melting of basaltic crustal materials, with a source material inferred to be depleted mantle-derived young crustal. These rocks were formed in a superimposed post-collisional and continental arc environment, possibly associated with the Mongol-Okhotsk Ocean closure and the oblique subduction of the Pacific plate. This study addresses a research gap regarding the volcanic rocks of the Longjiang formation in this area. Its findings can be applied to exploration and prospecting in the region.
Synergistic Leaching of Titanium, Aluminum, and Magnesium Components during Dilute Acid Pressure Treatment of High-Titanium Blast Furnace Slag
Authors: Yuan Ke , He Siqi , Yu Bo , Qian Shiyi , Wu Xueyu , Li Wenyi , Zhao Chunmeng
Published: July 2024

This study focuses on an improved leaching process through the combination of pressurized conditions and direct filtration of acid leaching slurry, which is conductive to improving the filterability of acid leaching systems and the extraction rates of Ti, Al, and Mg components. The effects of sulfuric acid concentration, reaction temperature, particle size of materials, acid–slag ratio, and reaction time on the leaching efficiency were systematically investigated. The results showed that pressurization significantly enhances the filtration efficiency of the reaction slurry. Under the same filtration time, the filtration efficiency increased from 46% under ordinary pressure to 78% under pressurized conditions. Moreover, under the optimal reaction conditions, the extraction rates of Ti, Al, and Mg components were more than 88.21%, 97.8%, and 96.31%, respectively. Additionally, XRD and FTIR showed that titanium oxide sulfate hydrate crystals were produced in the acid-leached residues when the reaction temperature exceeded 190 °C, thereby reducing the extraction rate of Ti component. And the XRD pattern shows that when the reaction temperature is maintained at 190 °C and the reaction time is extended to 150 min, titanium oxide sulfate hydrate crystals will be formed to reduce the extraction rate of the Ti component. In summary, this study not only provides important theoretical support for the resource utilization of high-titanium blast furnace slag but also offers a feasible solution for efficient extraction and convenient filtration, thus holding significant academic and practical implications.
Progress and Challenges of Vanadium Oxide Cathodes for Rechargeable Magnesium Batteries
Authors: Tolstopyatova Elena G. , Salnikova Yulia D. , Holze Rudolf , Kondratiev Veniamin V.
Published: July 2024

Among the challenges related to rechargeable magnesium batteries (RMBs) still not resolved are positive electrode materials with sufficient charge storage and rate capability as well as stability and raw material resources. Out of the materials proposed and studied so far, vanadium oxides stand out for these requirements, but significant further improvements are expected and required. They will be based on new materials and an improved understanding of their mode of operation. This report provides a critical review focused on this material, which is embedded in a brief overview on the general subject. It starts with the main strategic ways to design layered vanadium oxides cathodes for RMBs. Taking these examples in more detail, the typical issues and challenges often missed in broader overviews and reviews are discussed. In particular, issues related to the electrochemistry of intercalation processes in layered vanadium oxides; advantageous strategies for the development of vanadium oxide composite cathodes; their mechanism in aqueous, “wet”, and dry non-aqueous aprotic systems; and the possibility of co-intercalation processes involving protons and magnesium ions are considered. The perspectives for future development of vanadium oxide-based cathode materials are finally discussed and summarized.
Elemental Profiling for the Detection of Food Mixtures: A Proof of Principle Study on the Detection of Mixed Walnut Origins Using Measured and Calculated Data
Authors: Müller Marie-Sophie , Erçetin Esra , Cvancar Lina , Oest Marie , Fischer Markus
Published: July 2024

Element profiling is a powerful tool for detecting fraud related to claims of geographical origin. However, these methods must be continuously developed, as mixtures of different origins in particular offer great potential for adulteration. This study is a proof of principle to determine whether elemental profiling is suitable for detecting mixtures of the same food but from different origins and whether calculated data from walnut mixtures could help to reduce the measurement burden. The calculated data used in this study were generated based on measurements of authentic, unadulterated samples. Five different classification models and three regression models were applied in five different evaluation approaches to detect adulteration or even distinguish between adulteration levels (10% to 90%). To validate the method, 270 mixtures of walnuts from different origins were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Depending on the evaluation approach, different characteristics were observed in mixtures when comparing the calculated and measured data. Based on the measured data, it was possible to detect admixtures with an accuracy of 100%, even at low levels of adulteration (20%), depending on the country. However, calculated data can only contribute to the detection of adulterated walnut samples in exceptional cases.
Multifunctional Hydrogel with 3D Printability, Fluorescence, Biodegradability, and Biocompatibility for Biomedical Microrobots
Authors: Wang Gang , Wang Sisi , Hu Tao , Shi Famin
Published: July 2024

As micron-sized objects, mobile microrobots have shown significant potential for future biomedical applications, such as targeted drug delivery and minimally invasive surgery. However, to make these microrobots viable for clinical applications, several crucial aspects should be implemented, including customizability, motion-controllability, imageability, biodegradability, and biocompatibility. Developing materials to meet these requirements is of utmost importance. Here, a gelatin methacryloyl (GelMA) and (2-(4-vinylphenyl)ethene-1,1,2-triyl)tribenzene (TPEMA)-based multifunctional hydrogel with 3D printability, fluorescence imageability, biodegradability, and biocompatibility is demonstrated. By using 3D direct laser writing method, the hydrogel exhibits its versatility in the customization and fabrication of 3D microstructures. Spherical hydrogel microrobots were fabricated and decorated with magnetic nanoparticles on their surface to render them magnetically responsive, and have demonstrated excellent movement performance and motion controllability. The hydrogel microstructures also represented excellent drug loading/release capacity and degradability by using collagenase, along with stable fluorescence properties. Moreover, cytotoxicity assays showed that the hydrogel was non-toxic, as well as able to support cell attachment and growth, indicating excellent biocompatibility of the hydrogel. The developed multifunctional hydrogel exhibits great potential for biomedical microrobots that are integrated with customizability, 3D printability, motion controllability, drug delivery capacity, fluorescence imageability, degradability, and biocompatibility, thus being able to realize the real in vivo biomedical applications of microrobots.
Lipidomic Analysis Reveals Branched-Chain and Cyclic Fatty Acids from Angomonas deanei Grown under Different Nutritional and Physiological Conditions
Authors: Santana-Filho Arquimedes Paixão , Pereira Aramís José , Laibida Letícia Adejani , Souza-Melo Normanda , DaRocha Wanderson Duarte , Sassaki Guilherme Lanzi
Published: July 2024

Angomonas deanei belongs to Trypanosomatidae family, a family of parasites that only infect insects. It hosts a bacterial endosymbiont in a mutualistic relationship, constituting an excellent model for studying organelle origin and cellular evolution. A lipidomic approach, which allows for a comprehensive analysis of all lipids in a biological system (lipidome), is a useful tool for identifying and measuring different expression patterns of lipid classes. The present study applied GC-MS and NMR techniques, coupled with principal component analysis (PCA), in order to perform a comparative lipidomic study of wild and aposymbiotic A. deanei grown in the presence or absence of FBS. Unusual contents of branched-chain iso C17:0 and C19:0-cis-9,10 and-11,12 fatty acids were identified in A. deanei cultures, and it was interesting to note that their content slightly decreased at the log phase culture, indicating that in the latter growth stages the cell must promote the remodeling of lipid synthesis in order to maintain the fluidity of the membrane. The combination of analytical techniques used in this work allowed for the detection and characterization of lipids and relevant contributors in a variety of A. deanei growth conditions.
A Density Functional Theory Study of the Physico-Chemical Properties of Alkali Metal Titanate Perovskites for Solar Cell Applications
Authors: Jouybar Shirzad , Naji Leila , Sarabadani Tafreshi Saeedeh , de Leeuw Nora H.
Published: July 2024

The urgent need to shift from non-renewable to renewable energy sources has caused widespread interest in photovoltaic technologies that allow us to harness readily available and sustainable solar energy. In the past decade, polymer solar cells (PSCs) and perovskite solar cells (Per-SCs) have gained attention owing to their low price and easy fabrication process. Charge transport layers (CTLs), transparent conductive electrodes (TCEs), and metallic top electrodes are important constituents of PSCs and Per-SCs, which affect the efficiency and stability of these cells. Owing to the disadvantages of current materials, including instability and high cost, the development of alternative materials has attracted significant attention. Owing to their more flexible physical and chemical characteristics, ternary oxides are considered to be appealing alternatives, where ATiO3 materials—a class of ternary perovskite oxides—have demonstrated considerable potential for applications in solar cells. Here, we have employed calculations based on the density functional theory to study the structural, optoelectronic, and magnetic properties of ATiO3 (A=Li, Na, K, Rb, and Cs) in different crystallographic phases to determine their potential as PSCs and Per-SCs materials. We have also determined thermal and elastic properties to evaluate their mechanical and thermal stability. Our calculations have revealed that KTiO3 and RbTiO3 possess similar electronic properties as half-metallic materials, while LiTiO3 and CsTiO3 are metallic. Semiconductor behavior with a direct band gap of 2.77 eV was observed for NaTiO3, and calculations of the optical and electronic properties predicted that NaTiO3 is the most appropriate candidate to be employed as a charge transfer layer (CTL) and bottom transparent conducting electrode (TCE) in PSCs and Per-SCs, owing to its transparency and large bandgap, whereas NaTiO3 also provided superior elastic and thermal properties. Among the metallic and half-metallic ATiO3 compounds, CsTiO3 and KTiO3 exhibited the most appropriate features for the top electrode and additional absorbent in the active layer, respectively, to enhance the performance and stability of these cells.
The Antisolvent Precipitation of CuZnOx Mixed Oxide Materials Using a Choline Chloride-Urea Deep Eutectic Solvent
Authors: Wallace William T. , Hayward James S. , Marsh Amy R. , Bartley Jonathan K.
Published: July 2024

Metal oxides have applications in a variety of different fields, and new synthesis methods are needed to control their properties and improve their performance as functional materials. In this study, we investigated a low-cost antisolvent precipitation method using a choline chloride-urea deep eutectic solvent to precipitate CuZnOx materials using water as the antisolvent. Using this methodology, the metal oxide materials can be precipitated directly from the deep eutectic solvent without the need for a high-temperature calcination step that can lead to a reduction in defects and surface area, which are important properties in applications such as catalysis.
A Recyclable Inorganic Lanthanide Cluster Catalyst for Chemoselective Aerobic Oxidation of Thiols
Authors: Wang Lijun , Qin Zixuan , Chen Lingxia , Qin Xinshu , Hou Jiaman , Wang Chao , Li Xuan , Duan Hongxia , Fang Bing , Wang Minlong , An Jie
Published: July 2024

Optimizing lanthanide catalyst performance with organic ligands often encounters significant challenges, including susceptibility to water or oxygen and complex synthesis pathways. To address these issues, our research focuses on developing inorganic lanthanide clusters with enhanced stability and functionality. In this study, we introduce the [Sm6O(OH)8(H2O)24]I8(H2O)8 cluster (Sm-OC) as a sustainable and efficient catalyst for the aerobic oxidation of thiols under heating conditions. The Sm-OC catalyst demonstrated remarkable stability, outstanding recyclability, and excellent chemoselectivity across a diverse range of functional groups in 38 different tests. Notably, it enables efficient unsymmetrical disulfide synthesis and prevents the formation of over-oxidized by-products, highlighting its superior performance. This Sm-OC catalyst provides a practical and robust tool for the precise construction of versatile disulfides, thus establishing a template for the broader use of lanthanide clusters in organic synthesis.
Area-Selective Atomic Layer Deposition of Ru Using Carbonyl-Based Precursor and Oxygen Co-Reactant: Understanding Defect Formation Mechanisms
Authors: Lodha Jayant Kumar , Meersschaut Johan , Pasquali Mattia , Billington Hans , Gendt Stefan De , Armini Silvia
Published: July 2024

Area selective deposition (ASD) is a promising IC fabrication technique to address misalignment issues arising in a top–down litho-etch patterning approach. ASD can enable resist tone inversion and bottom–up metallization, such as via prefill. It is achieved by promoting selective growth in the growth area (GA) while passivating the non-growth area (NGA). Nevertheless, preventing undesired particles and defect growth on the NGA is still a hurdle. This work shows the selectivity of Ru films by passivating the Si oxide NGA with self-assembled monolayers (SAMs) and small molecule inhibitors (SMIs). Ru films are deposited on the TiN GA using a metal-organic precursor tricarbonyl (trimethylenemethane) ruthenium (Ru TMM(CO)3) and O2 as a co-reactant by atomic layer deposition (ALD). This produces smooth Ru films (<0.1 nm RMS roughness) with a growth per cycle (GPC) of 1.6 Å/cycle. Minimizing the oxygen co-reactant dose is necessary to improve the ASD process selectivity due to the limited stability of the organic molecule and high reactivity of the ALD precursor, still allowing a Ru GPC of 0.95 Å/cycle. This work sheds light on Ru defect generation mechanisms on passivated areas from the detailed analysis of particle growth, coverage, and density as a function of ALD cycles. Finally, an optimized ASD of Ru is demonstrated on TiN/SiO2 3D patterned structures using dimethyl amino trimethyl silane (DMA-TMS) as SMI.
Growth of Monolayer MoS2 Flakes via Close Proximity Re-Evaporation
Authors: Napoleonov Blagovest , Petrova Dimitrina , Minev Nikolay , Rafailov Peter , Videva Vladimira , Karashanova Daniela , Ranguelov Bogdan , Atanasova-Vladimirova Stela , Strijkova Velichka , Dimov Deyan , Dimitrov Dimitre , Marinova Vera
Published: July 2024

We report a two-step growth process of MoS2 nanoflakes using a low-pressure chemical vapor deposition technique. In the first step, a MoS2 layer was synthesized on a c-plane sapphire substrate. This layer was subsequently re-evaporated at a higher temperature to form mono- or few-layer MoS2 flakes. As a result, the close proximity re-evaporation enabled the growth of pristine MoS2 nanoflakes. Atomic force microscopy analysis confirmed the synthesis of nanoclusters/nanoflakes with lateral dimensions of over 10 μm and a flake height of approximately 1.3 nm, demonstrating bi-layer MoS2, whereas transmission electron microscopy analysis revealed triangular MoS2 nanoflakes, with a diffraction pattern proving the presence of single crystalline hexagonal MoS2. Raman data revealed the typical modes of high-quality MoS2 nanoflakes. Finally, we presented the photocurrent dependence of a MoS2-based photoresist under illumination with light-emitting diode of 405 nm wavelength. The measured current–voltage dependence across various luminous flux outlined the sensitivity of MoS2 to polarized light and thus opens further opportunities for applications in high-performance photodetectors with polarization sensitivity.
Colloidal Titanium Nitride Nanoparticles by Laser Ablation in Solvents for Plasmonic Applications
Authors: Pliatsikas Nikolaos , Panos Stavros , Odutola Tamara , Kassavetis Spyridon , Papoulia Chrysanthi , Fekas Ilias , Arvanitidis John , Christofilos Dimitris , Pavlidou Eleni , Gioti Maria , Patsalas Panos
Published: July 2024

Titanium nitride (TiN) is a candidate material for several plasmonic applications, and pulsed laser ablation in liquids (PLAL) represents a rapid, scalable, and environmentally friendly approach for the large-scale production of nanomaterials with customized properties. In this work, the nanosecond PLAL process is developed, and we provide a concise understanding of the process parameters, such as the solvent and the laser fluence and pulse wavelength, to the size and structure of the produced TiN nanoparticles (NPs). TiN films of a 0.6 μm thickness developed by direct-current (DC) magnetron sputtering were used as the ablation targets. All laser process parameters lead to the fabrication of spherical NPs, while the laser pulse fluence was used to control the NPs’ size. High laser pulse fluence values result in larger TiN NPs (diameter around 42 nm for 5 mJ and 25 nm for 1 mJ), as measured from scanning electron microscopy (SEM). On the other hand, the wavelength of the laser pulse does not affect the mean size of the TiN NPs (24, 26, and 25 nm for 355, 532, and 1064 nm wavelengths, respectively). However, the wavelength plays a vital role in the quality of the produced TiN NPs. Shorter wavelengths result in NPs with fewer defects, as indicated by Raman spectra and XPS analysis. The solvent type also significantly affects the size of the NPs. In aqueous solutions, strong oxidation of the NPs is evident, while organic solvents such as acetone, carbides, and oxides cover the TiN NPs.
Parenteral Nutrition, Inflammatory Bowel Disease, and Gut Barrier: An Intricate Plot
Authors: Covello Carlo , Becherucci Guia , Di Vincenzo Federica , Del Gaudio Angelo , Pizzoferrato Marco , Cammarota Giovanni , Gasbarrini Antonio , Scaldaferri Franco , Mentella Maria Chiara
Published: July 2024

Malnutrition poses a critical challenge in inflammatory bowel disease, with the potential to detrimentally impact medical treatment, surgical outcomes, and general well-being. Parenteral nutrition is crucial in certain clinical scenarios, such as with patients suffering from short bowel syndrome, intestinal insufficiency, high-yielding gastrointestinal fistula, or complete small bowel obstruction, to effectively manage malnutrition. Nevertheless, research over the years has attempted to define the potential effects of parenteral nutrition on the intestinal barrier and the composition of the gut microbiota. In this narrative review, we have gathered and analyzed findings from both preclinical and clinical studies on this topic. Based on existing evidence, there is a clear correlation between short- and long-term parenteral nutrition and negative effects on the intestinal system. These include mucosal atrophic damage and immunological and neuroendocrine dysregulation, as well as alterations in gut barrier permeability and microbiota composition. However, the mechanistic role of these changes in inflammatory bowel disease remains unclear. Therefore, further research is necessary to effectively address the numerous gaps and unanswered questions pertaining to these issues.
Serum Branched-Chain Amino Acids and Long-Term Complications of Liver Cirrhosis: Evidence from a Population-Based Prospective Study
Authors: Zhu Yichen , Guo Chengnan , Fan Hong , Han Xinyu , Li Yi , Chen Xingdong , Zhang Tiejun
Published: July 2024

Background and Aims: The role of serum branched-chain amino acids (BCAAs) in long-term liver cirrhosis complication events remains unclear. We aimed to evaluate the associations between serum BCAAs and the risk of liver-related events. Methods: We included a total of 64,005 participants without liver cirrhosis complication events at baseline from the UK Biobank. Cox proportional hazards regression models were utilized to estimate multivariable hazard ratios (HRs) and 95% CIs for the incidence of liver cirrhosis complication events, adjusting for potential confounders, including sociodemographic and lifestyle factors. Relationships between serum BCAAs and liver cirrhosis complications were examined using nonparametrically restricted cubic spline regression. Results: During a median follow-up of 12.7 years, 583 participants developed liver cirrhosis complication events. The multivariable Cox regression model suggested that total BCAAs (HR  =  0.88, 95% CI 0.82–0.95), serum leucine (HR  =  0.88, 95% CI 0.81–0.95), serum isoleucine (HR  =  0.88, 95% CI 0.82–0.96), and serum valine (HR  =  0.87, 95% CI 0.82–0.96) were all independent protective factors for liver cirrhosis complications after adjustment for sociodemographic and lifestyle factors. Cox models with restricted cubic splines showed U-shaped associations between serum valine and liver cirrhosis complication incidence. Serum total BCAA and isoleucine concentrations might reduce the risk of liver cirrhosis complications by raising the risk of (type 2 diabetes mellitus) T2DM. Conclusion: Lower serum BCAA levels exacerbate the long-term risk of liver cirrhosis complications. Future studies should confirm these findings and identify the biological pathways of these associations.
The Impact of Malnutrition on Chronic Obstructive Pulmonary Disease (COPD) Outcomes: The Predictive Value of the Mini Nutritional Assessment (MNA) versus Acute Exacerbations in Patients with Highly Complex COPD and Its Clinical and Prognostic Implications
Authors: Di Raimondo Domenico , Pirera Edoardo , Pintus Chiara , De Rosa Riccardo , Profita Martina , Musiari Gaia , Siscaro Gherardo , Tuttolomondo Antonino
Published: July 2024

Background: Current management of COPD is predominantly focused on respiratory aspects. A multidimensional assessment including nutritional assessment, quality of life and disability provides a more reliable perspective of the true complexity of COPD patients. Methods: This was a prospective observational study of 120 elderly COPD patients at high risk of acute exacerbations. The Mini Nutritional Assessment (MNA) was administered in addition to the usual respiratory assessment. The primary outcome was a composite of moderate or severe acute exacerbations during 52 weeks of follow-up. Results: The median MNA Short Form (SF) score was 11 (8–12), 39 participants (32.50%) had a normal nutritional status, 57 (47.5%) were at risk of malnutrition and 24 (20%) were malnourished. Our multivariate linear regression models showed that the MNA score was associated with dyspnea and respiratory symptom severity, assessed by the Modified British Medical Research Council (mMRC) scale and the COPD Assessment Test (CAT) score, with spirometric variables, in particular with the severity of airflow limitation based on the value of FEV1, and with poorer QoL, as assessed by the EQ-5D-3 questionnaire. Competing risk analysis according to nutritional status based on the MNA Total Score showed that COPD participants “at risk of malnutrition” and “malnourished” had a higher risk of moderate to severe acute exacerbations with sub-hazard ratios of 3.08 (1.40–6.80), p = 0.015, and 4.64 (1.71–12.55), p = 0.0002, respectively. Conclusion: Our study confirms the importance of assessing nutritional status in elderly COPD patients and its prognostic value.
Beaming Bodies: A Neo-Lockean Account of Material Persistence
Authors: Hanley Richard Mark
Published: July 2024

Conventional wisdom holds that human bodies do not and cannot persist through beaming: scanning and destruction of the body, followed by transmission of the scan information and replication of the body in another location. I argue that given the minimal time travel assumption that information can be sent into the past, it is logically possible for (duplicates of) human bodies to exist in object loops. If so, then conventional wisdom is wrong, and bodies can persist through beaming. The lesson generalizes to all composite material objects that can persist through intrinsic change.
The Relationship between Allometric Growth and the Stoichiometric Characteristics of Euhalophyte Suaeda salsa L. Grown in Saline–Alkali Lands: Biological Desalination Potential Prediction
Authors: Wang Yanyan , Guo Tongkai , Liu Qun , Hu Zhonglin , Tian Changyan , Hu Mingfang , Mai Wenxuan
Published: July 2024

The morphological adjustments of euhalophytes are well-known to be influenced by the soil-soluble salt variation; however, whether and how these changes in morphological traits alter the biomass allocation pattern remains unclear, especially under different NaCl levels. Therefore, an allometric analysis was applied to investigate the biomass allocation pattern and morphological plasticity, and the carbon (C), nitrogen (N), and phosphorus (P) stoichiometric characteristics of the euhalophyte Suaeda Salsa (S. salsa) at the four soil-soluble salt levels of no salt (NS), light salt (LS), moderate salt (MS), and heavy salt (HS). The results showed that soil-soluble salts significantly change the biomass allocation to the stems and leaves (p < 0.05). With the growth of S. salsa, the NS treatment produced a downward leaf mass ratio (LMR) and upward stem mass ratio (SMR); this finding was completely different from that for the salt treatments. When S. salsa was harvested on the 100th day, the HS treatment had the highest LMR (61%) and the lowest SMR (31%), while the NS treatment was the opposite, with an LMR of 44% and an SMR of 50%. Meanwhile, the soil-soluble salt reshaped the morphological characteristics of S. salsa (e.g., root length, plant height, basal stem diameter, and leaf succulence). Combined with the stoichiometric characteristics, N uptake restriction under salt stress is a vital reason for inhibited stem growth. Although the NS treatment had the highest biomass (48.65 g root box−1), the LS treatment had the highest salt absorption (3.73 g root box−1). In conclusion, S. salsa can change its biomass allocation pattern through morphological adjustments to adapt to different saline–alkali habitats. Moreover, it has an optimal biological desalting effect in lightly saline soil dominated by NaCl.
Investigating Cross-Linking Parameters and Molecular Arrangement in Liquid Crystalline Epoxy Monomer with Aromatic Diamine: DSC-TOPEM® and WAXS Analysis
Authors: Zając Weronika , Mossety-Leszczak Beata , Kisiel Maciej , Włodarska Magdalena , Szałański Piotr
Published: July 2024

This study presents the characterization of cross-linking parameters of a liquid crystalline epoxy monomer with an aromatic diamine as a curing agent. The mixture tested consisted of bis [4-(10,11-epoxyundecanoyloxy)benzoate] p-phenylene (LCEM) and 1,3-phenylenediamine (1,3-PDA). This paper focuses on the structural characterization of such systems using X-ray analysis. To investigate this, a comprehensive analysis was conducted using Differential Scanning Calorimetry (DSC) and Wide-Angle X-ray Scattering (WAXS). Through DSC analysis, the curing behavior and transition temperature of the liquid crystal epoxy system were established. To fully characterize the cross-linking of the system, a novel technique called DSC-TOPEM® was employed. The use of this technique enabled real-time monitoring of the curing process and provided precise information on the cross-linking energy, which resulted in the finding that the mixture was cross-linking faster than expected. WAXS analysis was performed to assess the structural changes formed during the cross-linking. The results of this analysis confirm that lower cross-linking temperatures of the mixture cause better ordering of mesogens than higher ones.
Production, Purification, and Characterization of a Cellulase from Paenibacillus elgii
Authors: Doan Chien Thang , Tran Thi Ngoc , Pham Thi Phuong , Tran Thi Thanh Thao , Truong Ba Phong , Nguyen Thi Tinh , Nguyen The Manh , Bui Thi Quynh Hoa , Nguyen Anh Dzung , Wang San-Lang
Published: July 2024

Cellulases are one of the most essential natural factors for cellulose degradation and, thus, have attracted significant interest for various applications. In this study, a cellulase from Paenibacillus elgii TKU051 was produced, purified, and characterized. The ideal fermentation conditions for cellulase productivity were 2% carboxymethyl cellulose (CMC) as the growth substrate, pH = 8, temperature of 31 °C, and 4 days of culturing. Accordingly, a 45 kDa cellulase (PeCel) was successfully purified in a single step using a High Q column with a recovery yield of 35% and purification of 42.2-fold. PeCel has an optimal activity at pH 6 and a temperature of 60 °C. The activity of cellulase was significantly inhibited by Cu2+ and enhanced by Mn2+. The PeCel-catalyzed products of the CMC hydrolysis were analyzed by high-performance liquid chromatography, which revealed chitobiose and chitotriose as the major products. Finally, the clarity of apple juice was enhanced when treated with PeCel.
Microcrystalline Cellulose—A Green Alternative to Conventional Soil Stabilizers
Authors: Arun Lazar , Sujatha Evangelin Ramani , Baldovino Jair Arrieta , Nuñez de la Rosa Yamid E.
Published: July 2024

Biopolymers are polymers of natural origin and are environmentally friendly, carbon neutral and less energy-intense additives that can be used for various geotechnical applications. Biopolymers like xanthan gum, carrageenan, chitosan, agar, gellan gum and gelatin have shown potential for improving subgrade strength, erosion resistance, and as canal liners and in slope stabilization. But minimal research has been carried out on cellulose-based biopolymers, particularly microcrystalline cellulose (MCC), for their application in geotechnical and geo-environmental engineering. In this study, the effect of MCC on select geotechnical properties of kaolin, a weak, highly compressible clay soil, like its liquid and plastic limits, compaction behavior, deformation behavior, unconfined compression strength (UCS) and aging, was investigated. MCC was used in dosages of 0.5, 1.0, 1.5 and 2% of the dry weight of the soil, and the dry mixing method was adopted for sample preparation. The results show that the liquid limit increased marginally by 11% but the plasticity index was nearly 74% higher than that of untreated kaolin. MCC rendered the treated soil stiffer, which is reflected in the deformation modulus, which increased with both dosage and age of the treated sample. The UCS of kaolin increased with dosage and curing period. The maximum UCS was observed for a dosage of 2% MCC at a 90-day curing period. The increase in stiffness and strength of the treated kaolin with aging points out that MCC can be a potential soil stabilizer.
High-Value and Environmentally Friendly Recycling Method for Coal-Based Solid Waste Based on Polyurethane Composite Materials
Authors: Li Xu , Liu Yang , Li Mingyi , Zhang Sitong , Jia Lan , Zhu Fengbo , Yu Wenwen
Published: July 2024

This study aims to provide a high-value and environmentally friendly method for the application of coal-based solid waste. Modified fly ash/polyurethane (MFA/PU) and modified coal gangue powder/polyurethane (MCG/PU) composites were prepared by adding different contents of MFA and MCG (10%, 20%, 30%, 40%). At the filler content of 30%, the compressive strengths of MFA/PU and MCG/PU are 84.1 MPa and 46.3 MPa, respectively, likely due to an improvement in interface compatibility, as indicated by scanning electron microscopy (SEM). The MFA/PU and MCG/PU composites present their highest limiting oxygen index (LOI) values of 29% and 23.5%, respectively, when their filler content is 30%. MFA has advantages in improving the LOIs of composites. Cone calorimetry (CCT) and SEM demonstrate that the two composites exhibit similar condensed-phase flame-retardant behaviors during combustion, which releases CO2 in advance and accelerates the formation of a dense barrier layer. Compared with the MFA/PU composites, the MCG/PU composites could produce a more stable and dense barrier structure. Water quality tests show that heavy metals do not leak from FA and CG embedded in PU. This work provided a new strategy for the safe and high-value recycling of coal-based solid waste.
Development of Innovative Composite Nanofiber: Enhancing Polyamide-6 with ε-Poly-L-Lysine for Medical and Protective Textiles
Authors: Purandare Saloni , Li Rui , Xiang Chunhui , Song Guowen
Published: July 2024

Polyamide-6 (PA) is a popular textile polymer having desirable mechanical and thermal properties, chemical stability, and biocompatibility. However, PA nanofibers are prone to bacterial growth and user discomfort. ε-Poly-L-lysine (PL) is non-toxic, antimicrobial, and hydrophilic but lacks spinnability due to its low molecular weight. Given its similar backbone structure to PA, with an additional amino side chain, PL was integrated with PA to develop multifunctional nanofibers. This study explores a simple, scalable method by which to obtain PL nanofibers by utilizing the structurally similar PA as the base. The goal was to enhance the functionality of PA by addressing its drawbacks. The study demonstrates spinnability of varying concentrations of PL with base PA while exploring compositions with higher PL concentrations than previously reported. Electrospinning parameters were studied to optimize the nanofiber properties. The effects of PL addition on morphology, hydrophilicity, thermal stability, mechanical performance, and long-term antimicrobial activity of nanofibers were evaluated. The maximum spinnable concentration of PL in PA-based nanofibers resulted in super hydrophilicity (0° static water contact angle within 10 s), increased tensile strength (1.02 MPa from 0.36 MPa of control), and efficient antimicrobial properties with long-term stability. These enhanced characteristics hold promise for the composite nanofiber’s application in medical and protective textiles.
Spatiotemporal Evolution in the Thermal Environment and Impact Analysis of Drivers in the Beijing–Tianjin–Hebei Urban Agglomeration of China from 2000 to 2020
Authors: Liu Haodong , Zheng Hui , Wu Liyang , Deng Yan , Chen Junjie , Zhang Jiaming
Published: July 2024

As urbanization advances, the issue of urban heat islands (UHIs) grows increasingly serious, with UHIs gradually transitioning into regional urban heat islands. There is still a lack of research on the evolution and drivers of the thermal environment in urban agglomerations; therefore, in this study, we used trend analysis methods and spatial statistical analysis tools to investigate these issues in the Beijing–Tianjin–Hebei (BTH) urban agglomeration. The results demonstrated the following: (1) The land surface temperature (LST) exhibited low fluctuation, while the relative land surface temperature (RLST) fluctuated significantly. In Zhangjiakou and Chengde, the LST and RLST evolution trends were complex, and the results differed between daytime and nighttime, as well as between the annual and seasonal scales. In other regions, the trends of LST and RLST evolution were more obvious. (2) During the daytime, the high UHI clusters centered on “BJ–TJ–LF” and “SJZ–XT–HD” formed gradually; during the nighttime, the high UHI clusters were mainly observed in built-up areas. The distribution range and direction of UHIs showed greater degrees of evolution during the daytime in summer. (3) The total UHI area showed an increasing trend, and the intensity of heat stress suffered by the BTH agglomeration was increasing. (4) In BTH and Hebei, aerosol optical depth, surface solar radiation, population density, and gross domestic product were the dominant factors influencing UHIs; moreover, in Beijing and Tianjin, all factors showed an basically equal impact. The methodology and findings of this study hold significant implications for guiding urban construction, optimizing urban structure, and improving urban thermal comfort in the BTH urban agglomeration.