bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine learning of atomic force microscopy images of organic solar cells
Authors: Kobayashi Yasuhito , Miyake Yuta , Ishiwari Fumitaka , Ishiwata Shintaro , Saeki Akinori
Published: May 2023

We incorporated atomic force microscopy images of polymer : non-fullerene acceptor organic photovoltaics into machine learning, where fast Fourier transform and grey-level co-occurrence matrix were utilized to predict power conversion efficiencies.
Correction: CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents
Authors: Peng Cong-Min , Wang Shih-Wei , Hwang Yi-Lin , Sun Wen-Chun , Chiu Li-Pin , Liu Yi-Ting , Lai Yu-Wei , Lee Hsueh-Yun
Published: May 2023

Correction for ‘CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents’ by Cong-Min Peng et al., RSC Adv., 2023, 13, 13169–13176, https://doi.org/10.1039/D3RA01927F.
Light-regulating chirality of metallacages featuring dithienylethene switches
Authors: Guo Shaomeng , Li Mengqi , Hu Honglong , Xu Ting , Xi Hancheng , Zhu Wei-Hong
Published: May 2023

Dynamic chiral superstructures are of vital importance for understanding the organization and function of chirality in biological systems.
Ion correlation and negative lithium transference in polyelectrolyte solutions
Authors: Bergstrom Helen K. , Fong Kara D. , Halat David M. , Karouta Carl A. , Celik Hasan C. , Reimer Jeffrey A. , McCloskey Bryan D.
Published: May 2023

We demonstrate that contrary to previous reports, transference number decreases with increasing degree of polymerization in non-aqueous lithium-bearing polyelectrolyte solutions that have been proposed as next-generation battery electrolytes.
Exploiting the fraternal twin nature of thermoelectrics and topological insulators in Zintl phases as a tool for engineering new efficient thermoelectric generators
Authors: Ogunbunmi Michael O. , Bobev Svilen
Published: May 2023

This review article presents how similar material features found in topological insulators and thermoelectrics can be leveraged to efficiently decouple electronic and phonon transports in order to improve thermoelectric figure of meritzT.
A multi‐criteria methodology with algebraic validation for the design of space vector switching sequences over a fundamental period horizon
Authors: Zucuni Jordan Pauleski , Schuetz Dimas Alã , de Morais Carnielutti Fernanda , Grigoletto Felipe Bovolini , Pinheiro Humberto
Published: May 2023

This paper presents a novel methodology for the design of the Space Vector (SV) switching sequences in order to reduce the output voltage distortion and the common‐mode voltage (CMV) without increasing the number of commutations in comparison to conventional and optimised techniques presented in the literature. Three spaces can be distinguished in a converter, referring to: line‐to‐line voltages, phase voltages and switching states. Consequently, three correspondent sequences of vectors in each space can be verified. The output voltage distortion, CMV and switching count are mainly affected, respectively, by the sequences in the line‐to‐line voltage, phase voltage and switching state spaces. However, the three spaces are interdependent, and the selection of a sequence in one space affects the ones in the other spaces. As a consequence, this paper presents a novel SV approach, where the line‐to‐line voltage sequences are selected over a fundamental period horizon considering the impact in the phase voltages through an algebraic analysis, assuring minimal phase voltage transitions while using VIKOR method to choose the best trade‐off between reduction of output voltage distortion and CMV. In order to validate the proposed strategy, experimental results are given to a three‐phase five‐level Packed U‐Cell (PUC5) converter.
Osteogenesis promotion by injectable methacryloylated gelatin containing psoralen and its bacteriostatic properties
Authors: Zhang Qi , Chu Fuhang , Xu Yingjie , Wu Xiaonan , Yu Jie , Cong Beibei , Wu Yingtao
Published: May 2023

The treatment of periodontitis focuses on controlling the progression of inflammation, reducing plaque accumulation, and promoting bone tissue reconstruction. Among them, the reconstruction of irregular bone resorption caused by periodontitis is a long‐standing challenge. At present, the local drug treatment of periodontitis is mainly anti‐inflammatory and antibacterial drugs. In this study, psoralen (Pso), a Chinese herbal medicine with anti‐inflammatory, antibacterial, and osteogenic effects, was selected for the local treatment of periodontitis. Meanwhile, an injectable methacrylate gelatin (GelMA) platform loading with Pso was constructed. Pso‐GelMA had the properties of fluidity, light cohesion, self‐healing, and slow release, which could be better used in the deep and narrow structure of the periodontal pocket, and greatly increased the effectiveness of local drug delivery. The pore size of Gelma hydrogel did not change after loading Pso by SEM. In vitro, Pso‐GelMA effectively upregulated the expression of osteogenic genes and proteins, increased alkaline phosphatase activity, promoted the mineralisation of rat bone marrow mesenchymal stem cells (BMSCs) extracellular matrix, and had significant antibacterial effects on Staphylococcus aureus and Fusobacterium nucleatum. Therefore, Pso‐GelMA has immense promise in the adjuvant treatment of periodontitis.
Direct assessment of SDO/HMI helioseismology of active regions on the Sun’s far side using SO/PHI magnetograms
Authors: Yang D. , Gizon L. , Barucq H. , Hirzberger J. , Orozco Suárez D. , Albert K. , Albelo Jorge N. , Appourchaux T. , Alvarez-Herrero A. , Blanco Rodríguez J. , Gandorfer A. , Germerott D. , Guerrero L. , Gutierrez-Marques P. , Kahil F. , Kolleck M. , Solanki S. K. , del Toro Iniesta J. C. , Volkmer R. , Woch J. , Pérez-Grande I. , Sanchis Kilders E. , Balaguer Jiménez M. , Bellot Rubio L. R. , Calchetti D. , Carmona M. , Deutsch W. , Feller A. , Fernandez-Rico G. , Fernández-Medina A. , García Parejo P. , Gasent Blesa J. L. , Grauf B. , Heerlein K. , Korpi-Lagg A. , Lange T. , López Jiménez A. , Maue T. , Meller R. , Moreno Vacas A. , Müller R. , Nakai E. , Schmidt W. , Schou J. , Schühle U. , Sinjan J. , Staub J. , Strecker H. , Torralbo I. , Valori G.
Published: May 2023

Context. Earth-side observations of solar p modes can be used to image and monitor magnetic activity on the Sun’s far side. In this work, we use magnetograms of the far side obtained by the Polarimetric and Helioseismic Imager (PHI) on board Solar Orbiter (SO) to directly assess the validity of far-side helioseismic holography for the first time.

Aims. We wish to co-locate the positions of active regions in helioseismic images and magnetograms and to calibrate the helioseismic measurements in terms of the magnetic field strength.

Methods. We identified three magnetograms displaying a total of six active regions on the far side from 18 November 2020, 3 October 2021, and 3 February 2022. The first two dates are from the SO cruise phase and the third is from the beginning of the nominal operation phase. We computed contemporaneous seismic phase maps for these three dates using helioseismic holography applied to the time series of Dopplergrams from the Helioseismic and Magnetic Imager (HMI) at the Solar Dynamics Observatory (SDO).

Results. Among the six active regions seen in SO/PHI magnetograms, five of them are identified on the seismic maps at almost the same positions as on the magnetograms. One region is too weak to be detected above the seismic noise. To calibrate the seismic maps, we fit a linear relationship between the seismic phase shifts and the unsigned line-of-sight magnetic field averaged over the active region areas extracted from the SO/PHI magnetograms.

Conclusions. SO/PHI provides the strongest evidence so far that helioseismic imaging is able to provide reliable information on active regions on the far side, including their positions, areas, and the mean unsigned magnetic field.
Main trends in the development of regional tourism and determining the prospects for its development
Authors: Chaplaev Huseyn , Idigova Lalita , Markaryan Varvara
Published: May 2023

The paper studies the importance of regional tourism for the country’s socio-economic development. The development of tourist organizations of the Chechen Republic was analyzed, statistical data and the results of marketing research of recent years were studied, thus providing insight into the development trends of regional tourism in the Russian Federation. Special attention is paid to the analysis of key figures for several reporting periods. In the realities of the present this issue remains relevant and gains new significance due to the modification of the external and internal conditions of the republic’s performance. The new conditions for the development of the republic affecting the change in the requirements to tourism include the transformation of the scale and directions of external economic relations, the increase in the utility estimate of the population mobility factor, the formation of new strategic guidelines for the socio-economic system of the republic. The paper noted that the inhibiting factors for the development of tourism are, first of all, the poor technical equipment of the tourism industry and the low level of professionalism of tourist personnel. In conclusion, the paper presents a list of measures that will contribute to the development of the tourism industry in the Chechen Republic.
Use of digital technologies in human resources management
Authors: Chaplaev Huseyn , Mazhiev Kazbek , Idigova Lalita
Published: May 2023

The paper is devoted to the study and analysis of modern trends of our time, such as globalization, the transition to a network digital economy, mobility, digitalization that encouraging companies to search for new competitive models of business management. The formation and development of a new strategy integrated with business and HR strategies becomes a prerequisite for future competitiveness by transforming the business from a traditional to a technological company. In today’s reality, digital HR management is inextricably linked to the formation and use of an innovative system for the introduction and dissemination of new knowledge, technologies and products at enterprises of the same region. Digital innovation in the human resources management system is a complete result of creative activity, which should be introduced into the labor market depending on the purpose. The paper identified the main reasons that impede digitalization in the field of personnel management, as well as the possibilities for their further solution, considered and analyzed the features of organizing a personnel management system at enterprises in the context of innovative digital transformation. The paper concluded that in recent year there has been an increase in the competitiveness of enterprises not so much due to new technologies for organizing production in the context of the transition to innovative development, but in terms of the introduction of personnel management methods using electronic digital technologies.
Formation of economic culture among cadets of a maritime university in the context of digitalization of education
Authors: Dorofeev Evgeny , Kozhukhar Tatiana , Magomedova Zamira
Published: May 2023

One of the significant problems in the professional training of future maritime transport specialists is the formation of an economic culture among modern cadets, which is necessary both for everyday life and for the quality performance of future official duties. The future professional activity of maritime transport specialists is associated with the constant performance of long-term voyages to various countries for the transportation, delivery, unloading and loading of various cargoes. During their stay in the ports of foreign countries, the command staff of transport ships interacts with representatives of these countries: customs officers, employees of port administrations, employees of various companies, cargo owners. Such interaction requires the master and his assistants to have a solid economic knowledge, economic thinking and economic culture.
Image of feminism in Russian media
Authors: Erofeeva Elena , Obukhova Irina
Published: May 2023

The purpose of the paper is to analyze Russian news content about feminism from the point of view of the event structure that is presented in the news. The research material is a corpus of headlines of Russian media publications demonstrated in the media news aggregator smi2.ru from 2014 to 2021. News headlines related to feminism (8,954) are automatically extracted from the entire array of texts to study the representation of feminism in the news agenda. The resulting subcorpus is analyzed in the IS Semograph, which allows carrying out a multilevel classification of content and automatically obtain data on the frequency of certain classes and their connection closeness. A three-level classification based on the analysis of events indicated in the news is created as a result of the material thematic analysis. It has been established that events in which the interacting parties are social groups, are covered most often. Actors oppose something (specific people, performances, etc.), and the news is mainly associated with coverage of actions and reactions of media people and the field of art. Frequency analysis of connections between event components allows modeling the event structure associated with feminism: the most typical structure of an event includes either feminist movements as a protagonist, or cultural and media figures who act for feminism and/or against specific individuals and organizations, trying to influence society as a whole, and these actions take place in the media space or in the cultural sphere. Therefore, the feminism image, which core is not the real problem and women rights, but mainly scandalous and illegal actions related to the field of art and media people, is constructed in the media.
Legal regulation of cross-border energy transportation
Authors: Semenov Andrey Viktorovich
Published: May 2023

In transportation business, special attention is paid to cross-border transportation of energy resources by various means of transport. Therefore, to evaluate legal regulation of transportation business, it is possible to dwell on the concept, international legal and national (Russian) legal regulation of cross-border energy transportation. There is no legal concept of cross-border transportation. Therefore, it should be defined based on some other sources. However, there is a concept of transboundary carriage defined as any carriage of hazardous wastes or other wastes from or through a jurisdictional territory of another state, to or through non-jurisdictional territory of any state, provided that such carriage involves at least two states. Legal regulation of cross-border energy transportation is an urgent issue in modern legislation. It will be useful to come up with a legal solution to regulate law enforcement activities. The author, exploring problematic issues, proposes to clarify and supplement laws in this area.
Evaluation of the manager work outcomes in a transport company in the context of digitalization
Authors: Gagarinskaya Galina Pavlovna , Gagarinsky Aleksandr Vladimirovich , Kremnev Arkadiy Alexandrovich , Igumenov Ilya Maksimovich
Published: May 2023

The authors study the process of digitalization in an organization, the impact on the competitiveness of personnel and leaders of organizations. The purpose of the study is to increase the competitiveness of managers who acquire competencies and new knowledge in the digitalization process. The paper highlights the elements of changes that digitalization brings to the organization. Research methods: systemic and structural-functional analysis, questioning, interviewing, expert assessments, statistical analysis, production experiment, timing and photography of working time. The information base of the study is public reports of leading transport companies; branch scientific and technical literature; materials of international, branch, territorial conferences, symposiums and seminars; results of application of author’s developments. Result: digitalization provides unhindered access to knowledge, cost reduction and greater interdisciplinarity, which is an obligation in external conditions of the society development.
Animalistic style in creative practices of contemporary artists and creative industries
Authors: Gomboeva Margarita , Ivanova Yuliya
Published: May 2023

The beginning of the 21st century is marked by the global demand for innovative (creative) industries, based on unique authorship, experience and personal talent. Cultural industries are systematically transformed into the main factor of the socio-economic transformation on the basis of updating the industrial culture of production, creation and cultivation of artistic geniuses. The new challenges of the global art development transform the infrastructure of intellectual and creative entrepreneurship, production and export of artistic works. This article explores the author's style formation on the basis of the creative interpretation of Old Turkic (Scythian, Central Asian) menagerie, widely represented in the artistic heritage of the region. The incorporation of the animalistic style of ancient civilizations in the creative practices of contemporary artists is accompanied by a deep philosophical, artistic, technical and technological reworking of the traditional code of the artistic culture. The article conceptualizes three types of the artistic continuity: the craftsmen type that reproduces the Mongolian craftsmen canon; the cultural institutions that convert the craft heritage into the contemporary creative industries and the rare type of craftsmen-artists who synthesize both approaches, rethinking the canon, traditional techniques and technology of working with traditional materials. All three types are represented by different systems of styling, the core of which is the animalistic style. Contemporary artisans Zhigzhit Bayaskhalanov and Dashi Namdakov create unique artistic images and metaphors, use innovative ways of shaping, and apply illogical, provocative and asymmetrical compositional solutions, transforming regional artistic traditions into leading global trends. The success of this experience is caused by socio-cultural, institutional factors (education, ethnicity, social origin from the rural handicrafts circle), ethno-cultural backgrounds (craft heritage, the presence of the family art collaboration). The empirical basis of the research consisted of 6 in-depth interviews and dozens of case studies from the participant observation.
Social inquiry for higher education in Russia: Sociological context
Authors: Isakova Yulia , Sagiryan Inga
Published: May 2023

The purpose of the work is to determine the characteristics of the social demand for higher education in Russia. The methodological basis of the research is built around the neo-institutional theory, namely D. North's theory of institutional evolution. A theoretical model of the social inquiry for higher education in Russia was developed; four factors with the greatest influence on the social demand were formulated: 1) social inertia; 2) market laws; 3) students' intentions; 4) fashion and trends. The research was conducted and the results of comprehension of features of the social demand for higher education in Russia were presented. The qualitative empirical research aimed at verification of the proposed model of the social inquiry along with the analysis and comparison of the importance of the formulated factors. The theoretical model of the social demand for higher education in Russia was developed; a comparison of concepts of the social inquiry was made.
Digital transformation and methodological aspects of education
Authors: Tokmazov Georgy , Parshutina Ludmila , Litvinova Tatiana , Abdurazakov Magomed , Litvinova Marina
Published: May 2023

The article studies the conceptual characteristics of education such as informatization, the impact of digital technologies on the goals, objectives and learning outcomes, the components of teacher's professional activity. The modern education system should be innovative marked by continuous education throughout life and self-education and the ability to update its structure in accordance with the requirements of society. New forms of education, in particular, those that implement “lifelong education”, are in demand in modern knowledge society, and the need for methods of educational and cognitive activities of educational subjects and their interaction in the information and educational space is increasing. Since the development of the lifelong education system implies the development and expansion of its constituent parts and the components of the methodological system of education through interaction with the content of the information and educational environment, education must develop and become informationally qualitative, corresponding to the level of the information society. The article emphasizes that in the digitalization and informatization educational system, goals, content, forms, and methods of teaching academic disciplines should be changed. The task of the methodology of education is to study the qualitative and quantitative impacts of digital technologies on the content of the information and educational environment, student’s personality and socioculture of the subject of education. The readiness of a teacher for professional and pedagogical activities in the information and educational environment is considered as professionally and personally significant qualities and ICT competencies. The teacher should creatively solve problems that arise in the educational and cognitive activities of students, be ready for qualitative changes in society and education influenced by digital technologies
The field model (F-model) of a psychological type as a new way of modeling and describing the psyche
Authors: Makhaev Mair Ruslanovich , Kindarova Zalina Badrudinovna , Magomedova Zukhra Zelemkhanovna
Published: May 2023

This article is the third one in a series of works on one of the leading theories in modern differential psychology – Jung's theory of the psychological types. The works are aimed at revealing foundations of the cognitive concept of psychological types, which is being developed by the scientific team of the Department of Psychology, Moscow International University, and the Laboratory of Cognitive Research of Consciousness n.a. S.M. Sattorov. The article aims to reveal new ways of identifying and describing psychological types in accordance with the field model of psychological types (F-model). Following Jung, the article claims that the basic psychological functions in the same individual never have the same degree of development. One of the functions has an advantage both in development and in strength. One of the functions is more preferable than the other. The strength of the functions within the field model (F model) can be determined by the degree of brightness in the field system. The field model describes the psychological type as a field system with a core and a periphery. The core is occupied by the strongest (dominant) mental functions, and the weakest (subdominant) mental functions are peripheral. To measure the strength of mental functions, the coefficient of brightness can be determined from the formula C = nP/Q. The article describes parameters of work with information and a four-point scale for its assessment, the structural specifics of the field model and the rules for constructing and describing the field model.
Green economy and waste management awareness
Authors: Salgiriev Emir , Umarkhadzhiev Magomed-Khabib , Mazhiev Kazbek
Published: May 2023

Due to the high population density of the world in the modern era, as well as the fact that more pollutants are thrown onto the Earth and more resources are spent purposefully, its inhabitants and resources are faced with the reality of environmental changes that can lead to catastrophe, if nothing is done. This article reveals the essence of the concepts of awareness of the green economy and waste management. The green economy is seen as a new path to sustainable development that extends the Earth's lifespan, protects natural resources, and benefits all living beings. The problem of the research is that people seem to be unaware of the relevance of the green economy and waste management, which is vital not only for human well-being, but also for the planet. The purpose of this article is to identify and evaluate people's awareness of waste management and the green economy, to increase the acceptance of the topic in general, to get a broader overview of the current business situation of how business people understand the topic from their point of view. The authors use a qualitative method by conducting semi-structured interviews on the Zoom platform. According to the results of the study, it is expected that businessmen are almost unaware of the concepts of the green economy, and the standard solutions do not fully consider the concepts of the green economy and waste management properly.
Contemporary social conflict: Socio-philosophical analysis of approaches
Authors: Zekrist Rida Irekovna , Abdrakhmanova Florida Rivhatovna
Published: May 2023

The paper investigates the essence of social conflict through the lens of social philosophy. In this regard, the authors outlined the main approaches to the study of this phenomenon. Traditional and contemporary views on the essence of social conflict were distinguished. The purpose of the study was to describe approaches to the study of the essence of social conflicts, typologies formed on their basis, and the dynamics of social conflicts that determine the self-development of a social system. A conceptual analysis of methodological approaches and the elements of a comparative analysis were employed as a methodological tool for studying social conflict. The research tasks triggered the search for answers to outstanding questions. As a result, the essence of social conflict was determined through the lens of social philosophy by identifying and comparing the main scientific approaches. A typology of social conflicts was compiled, and a universal structure and dynamics of the development was determined. The conceptual analysis revealed the complex systemic nature of the social conflict, which requires further methodological research.
Liebe Leser*innen,
Authors: Franke-Luderer Daniela
Published: May 2023

auch in dieser Ausgabe haben wir wieder eine originelle Mischung aktueller Pflegethemen aus der Psychiatrie für Sie zusammengestellt.
Auswirkungen der COVID-19-Pandemie auf das Leben von Menschen mit Schizophrenie
Authors: Baumann Lisa
Published: May 2023

COVID-19 beeinflusst die psychische Gesundheit vieler Menschen. Vor allem Menschen mit psychischen Erkrankungen gelten als Risikogruppe, da sie Belastungen besonders intensiv erfahren. Im Rahmen einer Masterarbeit wurden Menschen mit Schizophrenie in Leitfadeninterviews zu ihren Ressourcen, Problemen und Wünschen befragt. Denn nur, wenn wir mit den betroffenen Personen direkt sprechen und ihnen Raum geben sich zu äußern, kann ihre Versorgung langfristig verbessert werden und Recovery gelingen.
Zufallsfund bei Archivarbeiten – ein Feldpostbrief mit
interessanten Verbindungen
Authors: Baschin Marion , Rath Natalie
Published: May 2023

Ausgehend von einem Zufallsfund, einem handschriftlichen Brief, in einer Abgabe
von Unterlagen des Deutschen Zentralvereins homöopathischer
Ärzte wird ein kurzer Einblick in die Arbeiten im
„Homöopathie-Archiv“ des Instituts für
Geschichte der Medizin der Robert Bosch Stiftung gegeben. Inhaltlich wirft das
Schriftstück ein Schlaglicht auf die Thematik Homöopathie und
Krieg.
Pars pro toto – Samuel Hahnemanns Lehre vom
Stellvertreterleid als Grundlage der klassischen
Homöopathie
Authors: Matner Andreas
Published: May 2023

Samuel Hahnemann kam in seiner späten, miasmatischen Schaffensphase zu
dem Ergebnis, dass es zwischen Krankheit und Symptom ein dialektisches
Verhältnis gibt. Er suchte es im Sinne des Pars-pro-toto-Grundsatzes
entelechial zu fassen: Das periphere Lokalsymptom, z. B. das
syphilitische Geschwür (Schanker), vikariiert als Teil das Ganze, das
heißt, es beschwichtigt stellvertretend die unsichtbare Gestalt der
chronischen Krankheit (z. B. der Syphilis) so lange, bis sie
homöopathisch geheilt wird. Wird das Stellvertretersymptom nur –
suppressiv – lokal behandelt, kommt es im Inneren des Organismus zum
Gestaltwandel der Pathologie (Metaschematismus), konkret zur
Verschärfung des ganzen chronischen Krankheitsprozesses.

Mit den beiden Begriffen Vikariation und Metaschematismus ist unmittelbar das
Denken der Homöopathie angesprochen. Von hier aus erschließen
sich nicht nur das medizinische Phänomen der Unterdrückung der
primären Krankheitsdynamik, sondern auch die Eigenart und Tradition der
klassischen Homöopathie. Sie ist dadurch gekennzeichnet, dass es ihr
immer um den Zusammenhang zwischen einer ganzheitlichen pathologischen
Problematik (Miasma, Essenz, primäre Psora, Basic Delusion) und ihrer
stellvertretenden symptomatischen Teilerscheinung geht.
Elektrokonvulsionstherapie in der neuen NVL Depression: vom
Unterschied zwischen Effektivität, Evidenz und
Empfehlungsgraden
Authors: Zilles-Wegner David , Sartorius Alexander
Published: May 2023

Die neue Nationale Versorgungsleitlinie (NVL) Unipolare Depression
enthält im Vergleich zur letzten Version von 2015 deutlich
differenziertere Aussagen und Empfehlungen zur Elektrokonvulsionstherapie (EKT).
Dies ist prinzipiell zu begrüßen, da hierdurch der besondere
Stellenwert der EKT in unterschiedlichen klinischen Situationen verdeutlicht
wird. Zugleich führte diese Ausdifferenzierung von Empfehlungen bei
Vorliegen bestimmter Merkmale depressiver Störungen (z. B.
psychotische Symptome, Suizidalität) jedoch dazu, dass in
Abhängigkeit von diesen Merkmalen unterschiedliche Empfehlungsgrade
für die EKT vergeben wurden. Was in der strikten Methodik eines
Leitlinienprozesses richtig und sinnvoll sein mag, kann für die
klinische Praxis teilweise verwirrend und widersprüchlich wirken. In
diesem Beitrag sollen daher die Zusammenhänge sowie vermeintlichen
Diskrepanzen zwischen Effektivität der EKT, wissenschaftlicher Evidenz
und Empfehlungsgrad der Leitlinie dargelegt und für die klinische
Anwendung aus Expertensicht kommentiert werden.
Development of an Immune Prognostic Model for Clear Cell Renal Cell Carcinoma Based on Tumor Microenvironment
Authors: Wang Munan , Song Qianqian , Song Zhijie , Xie Yuduan
Published: May 2023

Immune infiltration remains at a high level in clear cell renal cell carcinoma (ccRCC). It has been confirmed that immune cell infiltration in tumor microenvironment (TME) is intimately bound up with the progression and the clinical outcome of ccRCC. The prognostic model, developed based on different immune subtypes of ccRCC, has a predictive value in patients’ prognosis. RNA sequencing data, somatic mutation data of ccRCC and clinical information were acquired from the cancer genome atlas (TCGA) database. The key immune-related genes (IRGs) were selected and by univariate Cox, LASSO, and multivariate Cox regression analyses. Then the ccRCC prognostic model was developed. The applicability of this model was verified in the independent dataset GSE29609. Thirteen IRGs including CCL7, ATP6V1C2, ATP2B3, ELAVL2, SLC22A8, DPP6, EREG, SERPINA7, PAGE2B, ADCYAP1, ZNF560, MUC20, and ANKRD30A were finally selected and a 13-IRGs prognostic model was developed. Survival analysis demonstrated that when compared with the low-risk group, patients in the high-risk group had a lower overall survival (p<0.05). AUC values based on the 13-IRGs prognostic model used to predict 3- and 5-year survival of ccRCC patients were greater than 0.70. And risk score was an independent prognostic factor (p<0.001). In addition, nomogram could accurately predict ccRCC patient’s prognosis. This 13-IRGs model can effectively evaluate the prognosis of ccRCC patients, and also provide guidance for the treatment and prognosis of ccRCC patients.
Adipose Tissue-Derived Stromal/Stem Cells Transplantation
with Cholecalciferol Supplementation in Recent-Onset Type 1 Diabetes Patients:
Twelve Months Follow-Up
Authors: Dantas Joana R. , Araujo Debora Batista , Silva Karina Ribeiro , Souto Debora Lopes , Pereira Maria de Fatima Carvalho , Raggio Luiz Ronir , Claudio-da Silva Cesar , Couri Carlos Eduardo , Maiolino Angelo , Rebellato Carmen Lucia Kuniyoshi , Daga Debora Regina , Senegaglia Alexandra Cristina , Brofman Paulo Roberto Slud , Baptista Leandra S. , Oliveira Jose Egidio Paulo de , Zajdenverg Lenita , Rodacki Melanie
Published: May 2023

To evaluate safety and therapeutic effect along 12 months of allogenic adipose
tissue-derived stromal/stem cells (ASCs) transplantation with
cholecalciferol (VITD) in patients with recent-onset type 1 diabetes (T1D).
Prospective, phase II, open trial, pilot study in which patients with recent
onset T1D received ASCs (1xKgx106 cells) and VITD 2000UI/day
for 12 months (group 1) and were compared to controls with standard insulin
therapy (group 2). Adverse events, C-peptide area under the curve (CPAUC),
insulin dose, HbA1c and frequency of FoxP3+ in CD4+ or
CD8+ T-cells(flow cytometry) were evaluated at baseline(T0), after
3(T3), 6(T6) and 12 months(T12). Eleven patients completed follow up (7:group
1;4:group 2). Group 1 had lower insulin requirement at
T3(0.24±0.18vs0.53±0.23UI/kg,p=0.04),
T6(0.24±0.15vs0.66±0.33 UI/kg,p=0.04) and
T12(0.39±0.15vs0.74±0.29 UI/Kg,p=0.04).HbA1c was
lower at T6
(50.57±8.56vs72.25±10.34 mmol/mol,p=0.01),
without differences at T12 (57.14±11.98 in group 1 vs.
73.5±14.57 mmol/min in group 2, p=0.16). CPAUC
was not significantly different between groups at T0(p=0.07), higher in
group 1 at T3(p=0.04) and T6(p=0.006), but similar at
T12(p=0.23). IDAA1c was significantly lower in group 1 than group 2 at
T3,T6 and T12 (p=0.006, 0.006 and 0.042, respectively). IDDA1c was
inversely correlated to FoxP3 expression in CD4 and CD8+ T cells at T6
(p<0.001 and p=0.01, respectively). In group 1, one patient had
recurrence of a benign teratoma that was surgically removed, not associated to
the intervention. ASCs with VITD without immunosuppression were safe and
associated lower insulin requirements, better glycemic control, and transient
better pancreatic function in recent onset T1D, but the potential benefits were
not sustained.
Practice Changes Induced by a Traveling Fellowship
Authors: Hollyer Ian , Cabell Akaila C. , Duncan Stephen T. , Rossi Stefano M. P. , Sculco Peter K. , Barnes C. Lowry , Amanatullah Derek F.
Published: May 2023

The John N. Insall Knee Society Traveling Fellowship selects four international arthroplasty or sports fellowship-trained orthopaedic surgeons to spend 1 month traveling to various Knee Society members' joint replacement and knee surgery centers in North America. The fellowship aims to foster research and education and shares ideas among fellows and Knee Society members. The role of such traveling fellowships on surgeon preferences has yet to be investigated. A 59-question survey encompassing patient selection, preoperative planning, intraoperative techniques, and postoperative protocols was completed by the four 2018 Insall Traveling Fellows before and immediately after the completion of traveling fellowship to assess anticipated practice changes (e.g., initial excitement) related to their participation in a traveling fellowship. The same survey was completed 4 years after the completion of the traveling fellowship to assess the implementation of the anticipated practice changes. Survey questions were divided into two groups based on levels of evidence in the literature. Immediately after fellowship, there was a median of 6.5 (range: 3–12) anticipated changes in consensus topics and a median of 14.5 (range: 5–17) anticipated changes in controversial topics. There was no statistical difference in the excitement to change consensus or controversial topics (p = 0.921). Four years after completing a traveling fellowship, a median of 2.5 (range: 0–3) consensus topics and 4 (range: 2–6) controversial topics were implemented. There was no statistical difference in the implementation of consensus or controversial topics (p = 0.709). There was a statistically significant decline in the implementation of changes in consensus and controversial preferences compared with the initial level of excitement (p = 0.038 and 0.031, respectively). After the John N. Insall Knee Society Traveling Fellowship, there is excitement for practice change in consensus and controversial topics related to total knee arthroplasty. However, few practice changes that had initial excitement were implemented after 4-year follow-up. Ultimately, the effects of time, practice inertia, and institutional friction overcome most of the anticipated changes induced by a traveling fellowship.
Interference Screw versus Cement Fixation in Anterior Cruciate Ligament Soft Tissue Grafts: A Biomechanical Study
Authors: Patel Jay , Kadkoy Yazan , Helbig Thomas , Rupani Mohammed , Cuppari Nicholas , Cortes Ricardo , Wetterstrand Charlene , Lu Michael T. , Paglia David N. , Galdi Balazs , Beiro Cristobal
Published: May 2023

Shortcomings of fixation have been reported as a source of graft failure in anterior cruciate ligament (ACL) reconstruction. While interference screws have long been used as fixation devices for ACL reconstruction, they are not without complications. Previous studies have highlighted the use of bone void filler as a fixation method; however, no biomechanical comparisons using soft tissue grafts with interference screws exist to our knowledge. The purpose of this study is to evaluate the fixation strength of a calcium phosphate cement bone void filler compared with screw fixation in an ACL reconstruction bone replica model with human soft tissue grafts. In total, 10 ACL grafts were constructed using semitendinosus and gracilis tendons harvested from 10 donors. Grafts were affixed with either an 8–10 mm × 23 mm polyether ether ketone interference screw (n = 5) or with approximately 8 mL of calcium phosphate cement (n = 5) into open cell polyurethane blocks. Graft constructs were tested to failure in cyclic loading under displacement control at a rate of 1 mm per second. When compared with screw construct, the cement construct showed a 978% higher load at yield, 228% higher load at failure, 181% higher displacement at yield, 233% higher work at failure, and a 545% higher stiffness. Normalized data for the screw constructs relative to the cement constructs from the same donor showed 14 ± 11% load at yield, 54 ± 38% load at failure, and 172 ± 14% graft elongation. The results of this study indicate that cement fixation of ACL grafts may result in a stronger construct compared with the current standard of fixation with interference screws. This method could potentially reduce the incidence of complications associated with interface screw placement such as bone tunnel widening, screw migration, and screw breakage.
Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee
Authors: Stratton Alex , Wanless Malcolm , Abidi Nicholas
Published: May 2023

Untreated osteoarthritis (OA)-related bone marrow lesions (OA-BML) can hasten the progression of knee OA. Previous studies have shown that fluoroscopically guided intraosseous calcium-phosphate (CaP) injections of OA-BML during knee arthroscopy can lead to pain reduction, improved functionality, and prolonged time until conversion to total knee arthroplasty (TKA). The purpose of this retrospective study is to compare the clinical outcomes of patients who underwent knee arthroscopy and CaP injection for OA-BML versus knee arthroscopy for non-OA-BML pathologies. Two-year follow-up data and patient-reported outcomes including knee injury and operative outcome scores, joint replacement scores (KOOS, JR) were available for 53 patients in the CaP group and 30 patients in the knee arthroscopy group. Results indicate that patients in the CaP group had less frequent conversion to TKA compared with patients in the knee arthroscopy group. Statistical analysis demonstrated a statistical difference between preoperative and postoperative KOOS, JR within the CaP group but not for the knee arthroscopy group. Two-year postoperative KOOS, JR for CaP patients was statistically greater than the 2-year postoperative KOOS, JR of knee arthroscopy patients. Results indicate greater improvement in functional outcomes with knee arthroscopy and CaP injection of OA-BML compared with knee arthroscopy alone for non-OA-BML diagnoses. The results of this retrospective study help to distinguish the benefits of knee arthroscopy accompanied by CaP intraosseous injection from that of knee arthroscopy alone.
Similar Midterm Outcomes of Total Knee Arthroplasties with Anterior and Posterior Tibial Slopes Performed on Paired Knees at a Minimum Follow-up of 5 Years
Authors: Song Sang Jun , Bae Dae Kyung , Hwang Sung Hyun , Park Hong Sik , Park Cheol Hee
Published: May 2023

A small posterior tibial slope (PTS) is generally recommended in posterior stabilized (PS) total knee arthroplasty (TKA). An unwanted anterior tibial slope (ATS), which can affect postoperative results, may be created in PS TKA because of the inaccuracy of surgical instruments and techniques, as well as high interpatient variability. We compared midterm clinical and radiographic results of PS TKAs with ATS and PTS performed on paired knees using the same prosthesis. One-hundred-twenty-four patients who underwent TKAs with ATS and PTS on paired knees using ATTUNE posterior-stabilized prostheses were retrospectively reviewed after a minimum follow-up period of 5 years. The mean follow-up period was 5.4 years. The Knee Society Knee and Function scores, Western Ontario and McMaster Universities Osteoarthritis Index, Feller and Kujalar scores, and range of motion (ROM) were evaluated. The preferred TKA out of ATS and PTS was also investigated. The hip-knee-ankle angle, component positions, tibial slope, posterior femoral offset, Insall–Salvati ratio, and knee sagittal angle were measured by radiography. There were no significant differences in the clinical results, including ROM, between TKAs with ATS and PTS preoperatively and at the last follow-up. Regarding patient preference, 58 patients (46.8%) were satisfied with bilateral knees, 30 (24.2%) preferred knees with ATS, and 36 (29%) preferred knees with PTS. There was no significant difference in the rate of preference between TKAs with ATS and PTS (p = 0.539). Except for the postoperative tibial slope (−1.8 vs. 2.5 degrees, p < 0.001), there were also no significant differences in the radiographic results, including the knee sagittal angle, preoperatively and at the last follow-up. The midterm outcomes were similar between PS TKAs with ATS and PTS performed on paired knees at a minimum of 5 years of follow-up. Nonsevere ATS did not affect midterm outcomes in PS TKA with proper soft tissue balancing and the current prosthesis of improved design. However, a long-term follow-up study is required to confirm the safety of nonsevere ATS in PS TKA.

Level of Evidence: III
The Accuracy of a Portable Accelerometer-Based Navigation System for Tibial Alignment Can be Reliable during Total Knee Arthroplasty for Obese Patients
Authors: Goto Kazumi , Hirota Jinso , Miyamoto Yoshinari , Katsuragawa Yozo
Published: May 2023

A portable accelerometer-based navigation system can be useful for achieving the target alignment. Tibial registration is based on the medial and lateral malleoli; however, the identification of landmarks may be difficult in obese (body mass index [BMI] >30 kg/m2) patients whose bones are not easily palpable from the body surface. This study compared tibial component alignment achieved using a portable accelerometer-based navigation system (Knee Align 2 [KA2]) in obese and control groups and aimed to validate the accuracy of bone cutting in obese patients. A total of 210 knees that underwent primary total knee arthroplasty using the KA2 system were included. After 1:3 propensity score matching, there were 32 and 96 knees in the BMI >30 group (group O) and BMI ≤30 group (group C), respectively. The absolute deviations of the tibial implant from the intended alignment were evaluated in the coronal plane (hip–knee–ankle [HKA] angle and medial proximal tibial angle) and sagittal plane (posterior tibial slope [PTS]). The inlier rate of each cohort, which was defined as tibial component alignment within 2 degrees of the intended alignment, was investigated. In the coronal plane, the absolute deviations of the HKA and MPTA from the intended alignment were 2.2 ± 1.8 degrees and 1.8 ± 1.5 degrees in group C and 1.7 ± 1.5 degrees and 1.7 ± 1.0 degrees in group O (p = 1.26, and p = 0.532). In the sagittal plane, the absolute deviations of the tibial implant were 1.6 ± 1.2 degrees in group C and 1.5 ± 1.1 degrees in group O (p = 0.570). The inlier rate was not significantly different between group C and group O (HKA: 64.6 vs. 71.9%, p = 0.521; MPTA: 67.7 vs. 78.1%, p = 0.372; PTS: 82.2 vs. 77.8%, p = 0.667). The accuracy of tibial bone cutting for the obese group was comparable to that of the control group. An accelerometer-based portable navigation system can be useful when attempting to achieve the target tibial alignment in obese patients.

Level of Evidence Level IV.
Nickel-Catalyzed Electrochemical Cyclizative Carboxylation of Alkene-Tethered Carbamoyl Chlorides with Carbon Dioxide
Authors: Wang Lin-Lin , Liu Xiao-Fei , Zhang Wen-Zhen , Wang He , Tao Li , Huang Jian , Ren Wei-Min , Lu Xiao-Bing
Published: May 2023

Nickel-catalyzed electrochemical cyclizative carboxylation of alkene-tethered carbamoyl chlorides with atmospheric carbon dioxide in an undivided cell under simple constant current conditions is reported. This reaction is conducted with high efficiency under mild conditions, providing a convenient and green access to valuable 2-oxoindolin-3-ylacetic acids and 2-oxo-tetrahydroquinoline-4-carboxylic acids.
Unilateral Thyroid Lobectomy as Day Care Procedure: A Cross Sectional Study with Literature Review on the Safety and Cost Effectiveness
Authors: Mughal Ainulakbar , Vardag Abdul Basit Shah , Deewani Muhammad Hammad , Wasif Muhammad , Mughal Marhaba , Awan Sohail , Unar Ambreen
Published: May 2023

Introduction Thyroid nodules are common globally in almost one fifth of the adult population. The gold standard treatment for thyroid nodule is thyroid lobectomy or total thyroidectomy depending upon the diagnosis. Thyroidectomy has a few known complications but, as per the ATA consensus statement, it is a safe surgery to be done as a day care procedure.

Objective To access the feasibility and safety of thyroid lobectomy as a day care surgery and its effect on decreasing overall financial burdens.

Methods This retrospective chart review was done from 2006 to 2022. A total of 736 patients underwent thyroid lobectomy among which only 56 were done as day care surgery. Data analysis was done using the IBM SPSS Statistics for Windows, Version 23.0 (IBM Corp., Armonk, NY, USA).

Results A total of 40% of the population was male. The mean age of the study population was 42 years. Bethesda II was the most encountered diagnosis, with a rate of 69%. The majority of patients were discharged after 6 hours of postoperative observation. The only complication encountered was seroma, which was seen in two patients.

Conclusion Thyroid lobectomy appears to be a safe procedure with a drastic difference in overall cost as a day care procedure. We recommend switching the practice of inpatient thyroid lobectomy to a day care procedure in carefully selected candidates. The major hurdle in day care lobectomy can be approval from insurance.