bluuebunny/crossref_metadata_2025 huggingface dataset:
El Verticalismo Residencial en La Habana Promovido por La Ley de Propiedad Horizontal (1952–1959)
Authors: Hernández Ruslan Muñoz , Méndez Alexis Jesús Rouco , González Beatriz Fernández
Published: December 2023

In 1952 Cuba joined the group of nations that had adopted the Horizontal or Surface Property regime in their legislation, a legal modality that represented a key moment in the urban development of Havana in the 1950s. This article is an approach to the impact of this law on the vertical growth of Havana between 1952 and 1959, with the El Vedado neighborhood as the epicenter of the ascent to the skies. The consultation of primary sources of information, which included architectural projects and legal studies associated with the law, as well as field work, allowed quantitatively documenting the influence of this mechanism on the dynamics of the real estate market, with the accelerated construction of thousands of apartment units. From the urban-architectural point of view, this study demonstrates how the implementation of the Horizontal Property legislation marked the vertical takeoff of the residential buildings, in El Vedado, shaping Havana’s skyline, almost unchanged for six decades.
New Light on the Oughterard Granite: Connemara’s S-Type Granite, Ireland
Authors: Leake Bernard Elgey
Published: December 2023

Most of the Connemara granites, including the Galway Granite batholith, have a clearly defined circular or ellipsoidal outcrop shape and are I-Type granites often with K-feldspar phenocrysts, whereas the Oughterard Granite (OG) forms numerous small intrusions scattered east-west over 40km with two larger linked bodies near Oughterard and is S-Type and aphyric. The only comprehensive mapping, mineralogical and chemical study of the OG was published over 50 years ago before the important 1974 recognition of the distinction of I- and S-Type granites was first made. New mapping of the southern Oughterard area with small OG intrusions is presented and many scattered published chemical and Rb, Sr, S and Pb isotopic studies integrated to confirm overall their individual conclusions that the peraluminous OG is of S-Type, being formed from melted Dalradian rocks as are the fluid-carried associated uneconomic mineral deposits. The OG is confined to the high sillimanite zone, mostly south of, and mainly later than, the 465-464Ma D4 Connemara Antiform, where a wide (>15km N-S) >70km E-W band of 469Ma gabbros and 467Ma quartz diorite gneisses intruded into already hot Dalradian rocks undergoing regional metamorphism. This generated the OG magmas by partial melting of pelites and semi-pelites. The upward intrusion of the OG magma was significantly delayed, as has been shown by precise dating in other granites elsewhere, to ~464-461Ma during the late stages and mostly after D4 but before the country rocks had completely cooled. The OG intrusions as a whole probably form the second largest area of S-Type granite in Ireland, after the Leinster Granite.
The Revolution in Black and White
Authors: Bay Mia
Published: December 2023

Abstract: The American Revolution in Black and White compares Black and white responses to the American colonists’ struggle for freedom from British domination. Focused on colonists who rallied in support of independence, it contends that although Americans on both sides of the color line mobilized around natural rights ideology, Black and white patriots were far too divided by race and class to understand the revolutionary rhetoric they embraced the same way. While Jefferson and other slave-holding patriot leaders saw declaring independence as a natter of state-making, Black patriots such as New Englander Lemuel Haynes pushed for a more expansive understanding of the colonist’s struggle for political freedom, and read the Declaration of Independence as a liberty-making document.
Early Black Thought Leaders and the Reframing of American Intellectual History
Authors: Newman Richard
Published: December 2023

Abstract: This essay examines the broad impact of African American thought leadership on early American intellectual history. Though marginalized in many mainstream histories of American intellectual life–which often focus on the emergence of Black philosophers and Black professional historians later in the 19th century -- early national Black thinkers helped shape public understanding of critical ideas in American society and politics, including the meaning of citizenship and civil rights, emancipation and equality, and racial justice. African Americans also influenced public discourses on other key topics in American intellectual life, including the nature of human dignity and spiritual redemption in the Second Great Awakening, the meaning of Romanticism and Transcendentalism in American reform culture, and the authority of science and technology in antebellum society. Using the concept of thought leadership as a framing device to understand the power and impact of early Black ideas, I follow recent trends in the field of African American intellectual history that focus on that way that African American men and women became public authorities on key ideas and issues in American culture between the American Revolution and Civil War. Though they did not often occupy positions of educational, institutional, or legal power (the main provinces of intellectual leadership), Black thought leaders had a significant impact on early American intellectual history.
How to Stop India's Authoritatarian Slide
Authors: Mukherji Rahul
Published: December 2023

Abstract: Since Prime Minister Narendra Modi and the Hindu-nationalist Bharatiya Janata Party (BJP) came to power in 2014, the India's democracy has flagged. Modi's government has been squeezing civic space, attacking the press, political opponents, and nongovernmental organizations (NGOs), and stoking ethnic tensions. The state has also used an array of laws to harass critics of the regime. Yet there is still a chance that the power of the vote will lead to a democratic revival. A regime is most vulnerable at an intermediate level of repression: where the state is undermining the rule of law to an extent that is significantly harmful to the political opposition and civil society, but the electoral door to democratic revival has not yet closed completely. This is precisely where India is today. The most promising avenue of democratic resistance is at the subnational level.
Why Separatism Is No Match for Democracy
Authors: Encarnación Omar G.
Published: December 2023

Abstract: A central paradox in the relationship between separatism and democracy is that while democracy provides a fertile environment for separatism—often by means of democracy's own institutions, mechanisms, and policies—democratic states are also well equipped to thwart and defeat separatist movements. The same pluralistic flexibility that allows pro-independence movements to blossom provides the tools to subvert and even crush separatist aspirations. Whether stonewalled by constitutional constraints, locked into systems of regional autonomy, undercut by counter-separatist movements, or cowed by the economic consequences of going it alone, separatist movements in democratic states are likely to turn quixotic. Catalonia and Scotland—two regions that only a few years ago seemed to be on the cusp of realizing longtime dreams of independence—prominently display the paradoxical politics inherent in separatism in democratic systems.
Rigorous coupled-wave analysis of unilateral Smith–Purcell radiation from asymmetric resonators
Authors: Chen Zhaofu , Shao Luqin , Mao Leilei , Yang Renjun , Shi Xin , Jin Mengmeng , Bai Ningfeng , Sun Xiaohan
Published: December 2023

The Smith–Purcell radiation produced by electrons moving closely to a grating can be enhanced by resonances. Here, we show a method to manipulate the directionality of the resonance-enhanced radiation. Using the rigorous coupled-wave analysis method, we compare the radiation from symmetric and asymmetric gratings, showing that the enhanced Smith–Purcell radiation can become unilateral with a perturbation that breaks the structural symmetry. Our work provides an effective method for frequency-domain calculation of Smith–Purcell radiation and also an approach to realize more efficient use of the radiation.
Coherent x-ray magnetic imaging with 5  nm resolution
Authors: Battistelli Riccardo , Metternich Daniel , Schneider Michael , Kern Lisa-Marie , Litzius Kai , Fuchs Josefin , Klose Christopher , Gerlinger Kathinka , Bagschik Kai , Günther Christian M. , Engel Dieter , Ropers Claus , Eisebitt Stefan , Pfau Bastian , Büttner Felix , Zayko Sergey
Published: December 2023

Soft x-ray microscopy plays an important role in modern spintronics. However, the achievable resolution of most x-ray magnetic imaging experiments limits access to fundamental and technologically relevant length scales in the sub-10 nm regime. Here, we demonstrate x-ray magnetic microscopy with 5 nm resolution by combining holography-assisted coherent diffractive imaging with heterodyne amplification of the weak magnetic signal. The gain in resolution and contrast makes magnetic pinning sites visible and allows to measure the local width of domain walls. The ability to detect and map such properties with photons opens new horizons for element-specific, time-resolved, and operando research on magnetic materials and beyond.
Ten simple rules for starting FAIR discussions in your community
Authors: Belliard Frédérique , Maineri Angelica Maria , Plomp Esther , Ramos Padilla Andrés Felipe , Sun Junzi , Zare Jeddi Maryam
Published: December 2023

This work presents 10 rules that provide guidance and recommendations on how to start up discussions around the implementation of the FAIR (Findable, Accessible, Interoperable, Reusable) principles and creation of standardised ways of working. These recommendations will be particularly relevant if you are unsure where to start, who to involve, what the benefits and barriers of standardisation are, and if little work has been done in your discipline to standardise research workflows. When applied, these rules will support a more effective way of engaging the community with discussions on standardisation and practical implementation of the FAIR principles.
GPT-4 can pass the Korean National Licensing Examination for Korean Medicine Doctors
Authors: Jang Dongyeop , Yun Tae-Rim , Lee Choong-Yeol , Kwon Young-Kyu , Kim Chang-Eop
Published: December 2023

Traditional Korean medicine (TKM) emphasizes individualized diagnosis and treatment. This uniqueness makes AI modeling difficult due to limited data and implicit processes. Large language models (LLMs) have demonstrated impressive medical inference, even without advanced training in medical texts. This study assessed the capabilities of GPT-4 in TKM, using the Korean National Licensing Examination for Korean Medicine Doctors (K-NLEKMD) as a benchmark. The K-NLEKMD, administered by a national organization, encompasses 12 major subjects in TKM. GPT-4 answered 340 questions from the 2022 K-NLEKMD. We optimized prompts with Chinese-term annotation, English translation for questions and instruction, exam-optimized instruction, and self-consistency. GPT-4 with optimized prompts achieved 66.18% accuracy, surpassing both the examination’s average pass mark of 60% and the 40% minimum for each subject. The gradual introduction of language-related prompts and prompting techniques enhanced the accuracy from 51.82% to its maximum accuracy. GPT-4 showed low accuracy in subjects including public health & medicine-related law, internal medicine (2), and acupuncture medicine which are highly localized in Korea and TKM. The model’s accuracy was lower for questions requiring TKM-specialized knowledge than those that did not. It exhibited higher accuracy in diagnosis-based and recall-based questions than in intervention-based questions. A significant positive correlation was observed between the consistency and accuracy of GPT-4’s responses. This study unveils both the potential and challenges of applying LLMs to TKM. These findings underline the potential of LLMs like GPT-4 in culturally adapted medicine, especially TKM, for tasks such as clinical assistance, medical education, and research. But they also point towards the necessity for the development of methods to mitigate cultural bias inherent in large language models and validate their efficacy in real-world clinical settings.
Time-resolved, integrated analysis of clonally evolving genomes
Authors: Legrand Carine , Andriantsoa Ranja , Lichter Peter , Raddatz Günter , Lyko Frank
Published: December 2023

Clonal genome evolution is a key feature of asexually reproducing species and human cancer development. While many studies have described the landscapes of clonal genome evolution in cancer, few determine the underlying evolutionary parameters from molecular data, and even fewer integrate theory with data. We derived theoretical results linking mutation rate, time, expansion dynamics, and biological/clinical parameters. Subsequently, we inferred time-resolved estimates of evolutionary parameters from mutation accumulation, mutational signatures and selection. We then applied this framework to predict the time of speciation of the marbled crayfish, an enigmatic, globally invasive parthenogenetic freshwater crayfish. The results predict that speciation occurred between 1986 and 1990, which is consistent with biological records. We also used our framework to analyze whole-genome sequencing datasets from primary and relapsed glioblastoma, an aggressive brain tumor. The results identified evolutionary subgroups and showed that tumor cell survival could be inferred from genomic data that was generated during the resection of the primary tumor. In conclusion, our framework allowed a time-resolved, integrated analysis of key parameters in clonally evolving genomes, and provided novel insights into the evolutionary age of marbled crayfish and the progression of glioblastoma.
High prevalence and diversity of Toxoplasma gondii DNA in feral cat feces from coastal California
Authors: Zhu Sophie , Camp Lauren , Patel Anika , VanWormer Elizabeth , Shapiro Karen
Published: December 2023

Toxoplasma gondii is a zoonotic parasite that can cause severe morbidity and mortality in warm-blooded animals, including marine mammals such as sea otters. Free-ranging cats can shed environmentally resistant T. gondii oocysts in their feces, which are transported through rain-driven runoff from land to sea. Despite their large population sizes and ability to contribute to environmental oocyst contamination, there are limited studies on T. gondii oocyst shedding by free-ranging cats. We aimed to determine the frequency and genotypes of T. gondii oocysts shed by free-ranging domestic cats in central coastal California and evaluate whether genotypes present in feces are similar to those identified in sea otters that died from fatal toxoplasmosis. We utilized a longitudinal field study of four free-ranging cat colonies to assess oocyst shedding prevalence using microscopy and molecular testing with polymerase chain reaction (PCR). T. gondii DNA was confirmed with primers targeting the ITS1 locus and positive samples were genotyped at the B1 locus. While oocysts were not visualized using microscopy (0/404), we detected T. gondii DNA in 25.9% (94/362) of fecal samples. We genotyped 27 samples at the B1 locus and characterized 13 of these samples at one to three additional loci using multi locus sequence typing (MLST). Parasite DNA detection was significantly higher during the wet season (16.3%, 59/362) compared to the dry season (9.7%; 35/362), suggesting seasonal variation in T. gondii DNA presence in feces. High diversity of T. gondii strains was characterized at the B1 locus, including non-archetypal strains previously associated with sea otter mortalities. Free-ranging cats may thus play an important role in the transmission of virulent T. gondii genotypes that cause morbidity and mortality in marine wildlife. Management of free-ranging cat colonies could reduce environmental contamination with oocysts and subsequent T. gondii infection in endangered marine mammals and people.
Market return spillover from the US to the Asia-Pacific Countries: The Role of Geopolitical Risk and the Information & Communication Technologies
Authors: Tran Minh Phuoc-Bao , Vo Duc Hong
Published: December 2023

This study examines the market return spillovers from the US market to 10 Asia-Pacific stock markets, accounting for approximately 91 per cent of the region’s GDP from 1991 to 2022. Our findings indicate an increased return spillover from the US stock market to the Asia-Pacific stock market over time, particularly after major global events such as the 1997 Asian and the 2008 global financial crises, the 2015 China stock market crash, and the COVID-19 pandemic. The 2008 global financial crisis had the most substantial impact on these events. In addition, the findings also indicate that US economic policy uncertainty and US geopolitical risk significantly affect spillovers from the US to the Asia-Pacific markets. In contrast, the geopolitical risk of Asia-Pacific countries reduces these spillovers. The study also highlights the significant impact of information and communication technologies (ICT) on these spillovers. Given the increasing integration of global financial markets, the findings of this research are expected to provide valuable policy implications for investors and policymakers.
Response of water yield to silvicultural treatments in a temperate forest in northern Mexico
Authors: Monárrez González José Carlos , Lopez-Gonzalez Celia , Marquez-Linares Marco Antonio , Perez-Verdin Gustavo
Published: December 2023

Forest management modifies tree cover, directly influencing various ecosystem services, such as water regulation. Evapotranspiration, water interception, surface runoff, stemflow, and throughfall are among those processes that depend on tree cover. The objective of this study was to evaluate the changes in water yield, defined as the difference between precipitation and evapotranspiration, after the application of silvicultural treatments in a temperate forest ecosystem in northern Mexico. Fifteen experimental plots were established in which the following treatments were applied: intensive management (clearcutting), semi-intensive management (selection, tree cutting of 59–61% of basal area), conservative management (selection, tree cutting of 29–31% of basal area), and no treatment (control group). Incident precipitation, throughfall, stemflow, net precipitation, interception, and surface runoff were analyzed. Results show that conservative management treatments increase water yield between 2 to 3.6 mm per m-2 ha-1 of tree basal area removed. Water flow distribution, in relation to the incident precipitation, ranged from 72.3 to 91.8% for throughfall, 0.2 to 0.4% for stemflow, 72.7 to 91.8% for net precipitation, 8.19 to 27.42% for interception or evaporation, and 0.54 to 1.93% for surface runoff. The conservative management treatment was the most viable alternative for increasing water yield without compromising timber harvesting and loss of soil due to hydric erosion.
Geometric morphometrics and paleoproteomics enlighten the paleodiversity of Pongo
Authors: Kubat Jülide , Paterson Ryan , Patramanis Ioannis , Barker Graeme , Demeter Fabrice , Filoux Arnaud , Kullmer Ottmar , Mackie Meaghan , Marques-Bonet Tomas , Huong Nguyen Thi Mai , Tuan Nguyen Anh , Pheng Sytha , Rippengal Jessica , Schrenk Friedemann , Souksavatdy Viengkeo , Tshen Lim Tze , Wattanapituksakul Athiwat , Wang Wei , Zanolli Clément , Cappellini Enrico , Bacon Anne-Marie
Published: December 2023

PleistocenePongoteeth show substantial variation in size and morphology, fueling taxonomic debates about the paleodiversity of the genus. We investigated prominent features of the enamel-dentine-junction junction (EDJ)–phylogenetically informative internal structures–of 71 fossilPongolower molars from various sites by applying geometric morphometrics and conducted paleoproteomic analyses from enamel proteins to attempt to identify extinct orangutan species. Forty-three orangutan lower molars representingPongo pygmaeusandPongo abeliiwere included for comparison. The shape of the EDJ was analyzed by placing five landmarks on the tip of the main dentine horns, and 142 semilandmarks along the marginal ridges connecting the dentine horns. Paleoproteomic analyses were conducted on 15 teeth of Late PleistocenePongousing high-resolution tandem mass spectrometry. The geometric morphometric results show variations in EDJ shape regarding aspects of the height and position of the dentine horns and connecting ridges. Despite the issue of molar position and sample size, modern molars are distinguished from fossil counterparts by their elongated tooth outline and narrowly positioned dentine horns. Proteomic results show that neither a distinction ofP.pygmaeusandP.abelii, nor a consistent allocation of fossil specimens to extant species is feasible. Based on the EDJ shape, the (late) Middle to Late PleistocenePongosamples from Vietnam share the same morphospace, supporting the previous allocation toP.devosi, although substantial overlap with Chinese fossils could also indicate close affinities withP.weidenreichi. The hypothesis that both species represent one chronospecies cannot be ruled out. Two fossil specimens, one from Tam Hay Marklot (Laos, Late Pleistocene), and another from Sangiran (Java, Early to Middle Pleistocene), along with some specimens within the Punung sample (Java), exhibit affinities withPongo abelii. The Punung fossils might represent a mix of early Late Pleistocene and later specimens (terminal Pleistocene to Holocene) related to modernPongo. The taxonomy and phylogeny of the complete Punung sample needs to be further investigated.
A study of deep active learning methods to reduce labelling efforts in biomedical relation extraction
Authors: Nachtegael Charlotte , De Stefani Jacopo , Lenaerts Tom
Published: December 2023

Automatic biomedical relation extraction (bioRE) is an essential task in biomedical research in order to generate high-quality labelled data that can be used for the development of innovative predictive methods. However, building such fully labelled, high quality bioRE data sets of adequate size for the training of state-of-the-art relation extraction models is hindered by an annotation bottleneck due to limitations on time and expertise of researchers and curators. We show here how Active Learning (AL) plays an important role in resolving this issue and positively improve bioRE tasks, effectively overcoming the labelling limits inherent to a data set. Six different AL strategies are benchmarked on seven bioRE data sets, using PubMedBERT as the base model, evaluating their area under the learning curve (AULC) as well as intermediate results measurements. The results demonstrate that uncertainty-based strategies, such as Least-Confident or Margin Sampling, are statistically performing better in terms of F1-score, accuracy and precision, than other types of AL strategies. However, in terms of recall, a diversity-based strategy, called Core-set, outperforms all strategies. AL strategies are shown to reduce the annotation need (in order to reach a performance at par with training on all data), from 6% to 38%, depending on the data set; with Margin Sampling and Least-Confident Sampling strategies moreover obtaining the best AULCs compared to the Random Sampling baseline. We show through the experiments the importance of using AL methods to reduce the amount of labelling needed to construct high-quality data sets leading to optimal performance of deep learning models. The code and data sets to reproduce all the results presented in the article are available at https://github.com/oligogenic/Deep_active_learning_bioRE.
Exome sequencing in 16 patients with pituitary stalk interruption syndrome: A monocentric study
Authors: Brauner Raja , Bignon-Topalovic Joelle , Bashamboo Anu , McElreavey Ken
Published: December 2023

Pituitary stalk interruption syndrome (PSIS) is a rare disorder characterized by an absent or ectopic posterior pituitary, absent or interrupted pituitary stalk and anterior pituitary hypoplasia on magnetic resonance imaging (MRI), as well in some cases a range of heterogeneous somatic anomalies. The triad can be incomplete. Here, we performed exome sequencing on 16 sporadic patients, aged 0.4 to 13.7 years diagnosed with isolated or complex PSIS. Growth hormone deficiency was isolated in 10 cases, or associated with thyrotropin deficiency in 6 others (isolated (2 cases), associated with adrenocorticotropin deficiency (1 case), gonadotropins deficiency (1 case), or multiple deficiencies (2 cases)). Additional phenotypic anomalies were present in six cases (37.5%) including four with ophthalmic disorders. In 13 patients variants were identified that may contribute to the phenotype. However, only a single individual carried a variant classified as pathogenic. This child presented with the typical clinical presentation of Okur-Chung neurodevelopmental syndrome due to a CSNK2A1 missense variant. We also identified variants in the holoprosencephaly associated genes GLI2 and PTCH1. A likely pathogenic novel splice site variant in the GLI2 gene was observed in a child with PSIS and megacisterna magna. In the remaining 11 cases 26 variants in genes associated with pituitary development or function were identified and were classified of unknown significance. Compared with syndromic forms the diagnostic yield in the isolated forms of PSIS is low. Although we identified rare or novel missense variants in several hypogonadotropic hypogonadism genes (e.g. FGF17, HS6ST1, KISS1R, CHD7, IL17RD) definitively linking them to the PSIS phenotype is premature. A major challenge remains to identify pathogenic variants in cases with isolated PSIS.
Global patterns of plumage color evolution in island-living passeriform birds
Authors: Oud Madison D. , Mahoney Sean M. , Pageau Claudie , de Menezes Marcio Argollo , Smith Nathan , Briskie James V. , Reudink Matthew W.
Published: December 2023

Island environments have the potential to change evolutionary trajectories of morphological traits in species relative to their mainland counterparts due to habitat and resource differences, or by reductions in the intensity of social or sexual selection. Latitude, island size, and isolation may further influence trait evolution through biases in colonization rates. We used a global dataset of passerine plumage color as a model group to identify selective pressures driving morphological evolution of island animals using phylogenetically-controlled analyses. We calculated chromaticity values from red and blue scores extracted from images of the majority of Passeriformes and tested these against the factors hypothesized to influence color evolution. In contrast to predictions based on sexual and social selection theory, we found consistent changes in island female color (lower red and higher blue chromaticity), but no change in males. Instead, island size and distance from mainland and other islands influenced color in both sexes, reinforcing the importance of island physiognomy in shaping evolutionary processes. Interactions between ecological factors and latitude also consistently influenced color for both sexes, supporting a latitudinal gradient hypothesis. Finally, patterns of color evolution varied among families, indicating taxon-specific microevolutionary processes in driving color evolution. Our results show island residency influences color evolution differently between sexes, but the patterns in both sexes are tempered by ecological, island characteristics, and phylogenetic effects that further vary in their importance among families. The key role of environmental factors in shaping bird plumage on islands further suggests a reduced importance of sexual and social factors in driving color evolution.
The impact of total factor mobility on rural-urban symbiosis: Evidence from 27 Chinese provinces
Authors: Zhu Xiangmei , Guo Shaohua , Yuan Hui
Published: December 2023

The rational flow and optimal allocation of urban and rural factors is the key to solving the problem of unbalanced and insufficient urban and rural development. This study draws on the theory of ecological symbiosis to examine the mechanism of factor flow and urban-rural symbiosis. It analyzes panel data from 27 Chinese provinces and autonomous regions between 2010 and 2020 to empirically demonstrate the influence of labor, capital, technology, and land mobility on urban-rural symbiosis. The study found that: (1) The relationship between the total factor flow and urban-rural symbiosis is U-shaped nonlinear, and the time when cities feed the development of rural areas has come; (2) The impact of labor factor flow on urban-rural symbiosis exhibits an inverted U-shaped relationship, the impact of capital factor flow displays a positive U-shaped relationship, the impact of land factor flow shows an inverted U-shaped relationship, and the impact of technical factor flow on urban-rural symbiotic development is not significant. (3) The factor flow exerts a region-oriented impact on the level of urban-rural symbiosis. In developed areas, total factor flow does not affect urban-rural symbiosis, but the level of labor flow and the urban-rural symbiosis demonstrates an inverted U-shaped relationship, the flow of technological factors has a U-shaped impact on the urban-rural symbiosis level, the flow of land factors and the urban-rural symbiosis show an inverted U-shaped relationship, and the flow of capital factors has no impact on the urban-rural symbiosis relationship. In underdeveloped areas, the impact of the total factor flow on urban-rural symbiosis shows a significantly positive U-shaped characteristic, the labor mobility level and urban-rural symbiosis show an inverted U-shaped relationship, the flow of capital factors has a U-shaped impact on the urban-rural symbiosis level, and the flow of lands and technology does not have a remarkable impact on urban-rural symbiosis in underdeveloped areas.
Efficacy of different courses of acupuncture for diarrhea irritable bowel syndrome: A protocol for systematic review and meta-analysis
Authors: Tian Junjian , Li Ting , Zhao Jun , Li Da , Sun Jingwen , Li Zhigang , Shi Rongxing
Published: December 2023

Irritable Bowel Syndrome (IBS) is the most common functional gastrointestinal disorder. As one of the most common subtypes of IBS, IBS-D can impair the patients’ quality of life (QOL) and decreased work productivity. Acupuncture may be a potential treatment for patients with IBS-D. However, the treatment course of acupuncture was diverse. It is unclear what is the optimal acupuncture treatment courses for acupuncture. The efficacy and safety of different courses of acupuncture for IBS-D have not been systematically evaluated yet. The purpose of this study is to evaluate effectiveness of Acupuncture of different courses in the treatment of IBS-D and provide sufficient evidence for clinical recommendations for IBS-D. We will follow the Preferred reporting items for systematic reviews and meta-analysis protocols (PRISMA-P) guidelines to design the protocol of a systematic review and meta-analysis. This systematic review is registered in PROSPERO (CRD42023418846). We will include randomized controlled trials (RCTs) in which the efficacy of Acupuncture is compared with a placebo, sham acupuncture or Pinaverium bromide in the treatment of IBS-D with no language restrictions. The outcomes of interest will be efficiency rate and the Symptoms Severity Score. RCTs will be searched in the electronic database and Clinical Trials Registry Platform from inception to April 2023. Two independent reviewers will independently select studies, extract data from the included studies, and assess the risk of bias using the Cochrane tool. We will choose a random or fixed-effects model based on the heterogeneity index. We will use the relative risk and mean difference to estimate data with 95% CI. A stratified meta-analysis was conducted to evaluate the effect of different treatment courses of Acupuncture: 2weeks, 4weeks(or 1 months), 6 weeks, and 8 weeks. If there is significant clinical and methodological heterogeneity, we will look for the reason for heterogeneity and perform a subgroup analysis. According to the Grading of Recommendations Assessment, Development and Evaluation (GRADE), we will evaluate the evidence quality and provide the recommendation’s strength.
Effects of a mindfulness-based intervention and a health self-management programme on psychological well-being in older adults with subjective cognitive decline: Secondary analyses from the SCD-Well randomised clinical trial
Authors: Schlosser Marco , Demnitz-King Harriet , Barnhofer Thorsten , Collette Fabienne , Gonneaud Julie , Chételat Gaël , Jessen Frank , Kliegel Matthias , Klimecki Olga M. , Lutz Antoine , Marchant Natalie L. ,   on behalf of the Medit-Ageing Research Group
Published: December 2023

Objectives

Older adults with subjective cognitive decline (SCD) recruited from memory clinics have an increased risk of developing dementia and regularly experience reduced psychological well-being related to memory concerns and fear of dementia. Research on improving well-being in SCD is limited and lacks non-pharmacological approaches. We investigated whether mindfulness-based and health education interventions can enhance well-being in SCD.

Methods

The SCD-Well trial (ClinicalTrials.gov: NCT03005652) randomised 147 older adults with SCD to an 8-week caring mindfulness-based approach for seniors (CMBAS) or an active comparator (health self-management programme [HSMP]). Well-being was assessed at baseline, post-intervention, and 6-month post-randomisation using the Psychological Well-being Scale (PWBS), the World Health Organisation’s Quality of Life (QoL) Assessment psychological subscale, and composites capturing meditation-based well-being dimensions of awareness, connection, and insight. Mixed effects models were used to assess between- and within-group differences in change.

Results

CMBAS was superior to HSMP on changes in connection at post-intervention. Within both groups, PWBS total scores, psychological QoL, and composite scores did not increase. Exploratory analyses indicated increases in PWBS autonomy at post-intervention in both groups.

Conclusion

Two non-pharmacological interventions were associated with only limited effects on psychological well-being in SCD. Longer intervention studies with waitlist/retest control groups are needed to assess if our findings reflect intervention brevity and/or minimal base rate changes in well-being.
A neural network model of mathematics anxiety: The role of attention
Authors: Rose Angela C. , Alashwal Hany , Moustafa Ahmed A. , Weidemann Gabrielle
Published: December 2023

Anxiety about performing numerical calculations is becoming an increasingly important issue. Termed mathematics anxiety, this condition negatively impacts performance in numerical tasks which can affect education outcomes and future employment. The disruption account proposes poor performance is due to anxiety disrupting limited attentional and inhibitory resources leaving fewer cognitive resources for the current task. This study provides the first neural network model of math anxiety. The model simulates performance in two commonly-used tasks related to math anxiety: the numerical Stroop and symbolic number comparison. Different model modifications were used to simulate high and low math-anxious conditions by modifying attentional processes and learning; these model modifications address different theories of math anxiety. The model simulations suggest that math anxiety is associated with reduced attention to numerical stimuli. These results are consistent with the disruption account and the attentional control theory where anxiety decreases goal-directed attention and increases stimulus-driven attention.
Using hypergraphs to quantify importance of sets of diseases by healthcare resource utilisation: A retrospective cohort study
Authors: Rafferty James , Lee Alexandra , Lyons Ronan A. , Akbari Ashley , Peek Niels , Jalali-najafabadi Farideh , Ba Dhafari Thamer , Lyons Jane , Watkins Alan , Bailey Rowena
Published: December 2023

Rates of Multimorbidity (also called Multiple Long Term Conditions, MLTC) are increasing in many developed nations. People with multimorbidity experience poorer outcomes and require more healthcare intervention. Grouping of conditions by health service utilisation is poorly researched. The study population consisted of a cohort of people living in Wales, UK aged 20 years or older in 2000 who were followed up until the end of 2017. Multimorbidity clusters by prevalence and healthcare resource use (HRU) were modelled using hypergraphs, mathematical objects relating diseases via links which can connect any number of diseases, thus capturing information about sets of diseases of any size. The cohort included 2,178,938 people. The most prevalent diseases were hypertension (13.3%), diabetes (6.9%), depression (6.7%) and chronic obstructive pulmonary disease (5.9%). The most important sets of diseases when considering prevalence generally contained a small number of diseases, while the most important sets of diseases when considering HRU were sets containing many diseases. The most important set of diseases taking prevalence and HRU into account was diabetes & hypertension and this combined measure of importance featured hypertension most often in the most important sets of diseases. We have used a single approach to find the most important sets of diseases based on co-occurrence and HRU measures, demonstrating the flexibility of the hypergraph approach. Hypertension, the most important single disease, is silent, underdiagnosed and increases the risk of life threatening co-morbidities. Co-occurrence of endocrine and cardiovascular diseases was common in the most important sets. Combining measures of prevalence with HRU provides insights which would be helpful for those planning and delivering services.
Severe Covid-19 in pregnant and postpartum women admitted to an intensive care unit: A retrospective cohort study
Authors: Melo Mendes Isabel Cristina , Martins de Oliveira Ana Luiza , Martins Pinheiro Trindade Priscila , Mendes da Silva Wallace , Pontes Frankel Patricia , Carvalho Mocarzel Carolina , de Alencar Rosa Marta , Santos Nascimento Ana Paula , de Melo Rodrigues Glaucia , Pimentel Clarisse , de Moraes Perlingeiro Raissa , Gonçalves Lisbôa Pereira Alessandra , Caminha Escosteguy Claudia , Mello Galliez Rafael
Published: December 2023

Background

SARS-CoV-2 infection is associated with worse maternal and fetal outcomes. This study aims to describe the characteristics of pregnant and postpartum women with severe Covid-19 admitted to ICU.

Methods and findings

It’s a retrospective cohort study evaluating pregnant and postpartum women referenced to a specialized ICU between May 2020 and June 2022. Covid-19 was confirmed with RT-PCR or rapid antigen test on a nasopharyngeal swab. Variables were described by median and IQR when numerical, and by frequency and percentage when categorical. OR with 95% CI were calculated for the evaluation of factors related to death. P-values were calculated using Pearson’s ꭓ2-test, Fisher’s exact test, Wilcoxon rank sum test, and Kruskall-Wallis test, and statistical significance was established as < 0·05. Missing data were excluded. All statistical analysis were performed using R software version 4.2.2. Of the 101 admissions, 85 (84·2%) were of pregnant women. Obesity (23·0%) and systemic arterial hypertension (13·0%) were the most prevalent medical conditions. Sixty-six (65·3%) were admitted using some type of oxygen support. Forty-seven (46·5%) evolved to mechanical ventilation. There were 61 events considered obstetric complications, with 8 stillbirths/fetal losses. The overall lethality was 15·8%. Pregnancy interruption, need for non-invasive mechanical ventilation, level of oxygen support at admission, prone maneuver, hemodialysis, and healthcare-related infections were factors associated with death. Evaluating the WHO 7-category ordinary scale, there was a trend of increase in the risk of death with higher punctuation, with a statistically significant difference of women with 5 (OR = 7·27; 95% IC = 1·17–194; p = 0·031) or 6 points (OR = 12·0; 95% IC = 1·15–391; p = 0·038) when compared to the ones with 3 points, i.e., of women admitted with a high-flow non-rebreathing mask or invasive mechanical ventilation, compared with the ones admitted at room air, respectively. The main limitations of this study are the relatively small number of participants, and the use of data derived of medical records—which are susceptible to misclassification and variable amounts of missing data.

Conclusions

Pregnant and postpartum women with severe Covid-19 have high lethality and a high incidence of clinical and obstetric complications. These findings support that this population should be prioritized in public health strategies that address Covid-19.
Modeling the larvae dispersion of sun coral in the Brazil current off Cape Frio: A cyclonic eddy scenario
Authors: Calado Leandro , Cosenza Bernardo , Moraes Francisco , Mizrahi Damián , Xavier Fabio C. , Batista Daniela , Calazans Sávio , Araújo Fernanda , Coutinho Ricardo
Published: December 2023

The study aims to understand the dispersal patterns of non-indigenous Tubastraea spp. (Sun Coral) larvae in the Brazil Current (BC), specifically in the Cape Frio recurrent cyclonic eddy (CFE) scenario. For this, the Regional Ocean Model System was used to simulate the hydrodynamic fields in a high-resolution nested grid, where a model of lagrangian floats, in a good approximation of the larvae properties and considering massive planulation events, was coupled with surface larval release from the Campos Basin area. The simulation was representative of mesoscale features compared to similar studies, ARGO vertical profiles and a py-eddy-track algorithm was used to obtain eddy variables, such as radius, rotational and translational velocities. These parameters are fundamental to access when an eddy tends to trap or not the water, heat and plankton in its interior. CFE turned out to be highly nonlinear, with a strong tendency to trap larvae in its core, acting as a dispersal constrictor when compared with the organisms in the axis of the higher speed of BC. A strong negative correlation (-0.75) was found between the days that larvae were inside the eddy and their distance from the origin. None of the 48,000 larvae released during simulated experiment a 16-day spawning event reached the coast. There are two different patterns for the dispersal, one along the shelf break and another, with higher larval density, off from the 1000 m isobath. The CFE’s presence allows larvae to remain in the same region for longer periods, although in offshore areas. Therefore, as there is considerable availability of fixed substrates on oil rig structures, larvae could settle on them resulting in a possible inter-platforms connectivity between populations of Tubastraea spp. Also, regions in the CFE that present downward vertical velocities (downwelling), may move young larvae to depths of about 60 m suggesting that subsurface colonizations are possible due to specific dynamics of propagating cyclonic eddies. So, identifying the main factors that affect the dispersion of propagules is essential to subsidize management policies for controlling bioinvasion associated with exploitation of hydrocarbon resources in offshore areas.
Acceptability of a community-embedded intervention for improving adolescent sexual and reproductive health in south-east Nigeria: A qualitative study
Authors: Eze Irene Ifeyinwa , Okeke Chinyere , Ekwueme Chinazom , Mbachu Chinyere Ojiugo , Onwujekwe Obinna
Published: December 2023

Introduction

Adolescents have limited access to quality sexual and reproductive health (SRH) services that are key to healthy sexual lives in many low and middle-income countries such as Nigeria. Hence, context-specific interventions are required to increase adolescents’ access to and utilisation of SRH. This paper provides new knowledge on the acceptability of a community-embedded intervention to improve access to SRH information and services for adolescents in Ebonyi state, southeast Nigeria.

Methods

A community-embedded intervention was implemented for six months in selected communities. Thereafter the intervention was assessed for its acceptability using a total of 30 in-depth interviews and 18 focus group discussions conducted with policymakers, health service providers, school teachers, community gatekeepers, parents and adolescents who were purposively selected as relevant stakeholders on adolescent SRH. The interview transcripts were coded in NVivo 12 using a coding framework structured according to four key constructs of the theoretical framework for acceptability (TFA): affective attitude, intervention coherence, perceived effectiveness, and self-efficacy. The outputs of the coded transcripts were analysed, and the emergent themes from each of the four constructs of the TFA were identified.

Results

The intervention was acceptable to the stakeholders, from the findings of its positive effects, appropriateness, and positive impact on sexual behaviour. Policymakers were happy to be included in collaborating with multiple stakeholders to co-create multi-faceted interventions relevant to their work (positive affective attitude). The stakeholders understood how the interventions work and perceived them as appropriate at individual and community levels, with adequate and non-complex tools adaptable to different levels of stakeholders (intervention coherence). The intervention promoted mutualistic relations across stakeholders and sectors, including creating multiple platforms to reach the target audience, positive change in sexual behaviour, and cross-learning among policymakers, community gatekeepers, service providers, and adolescents (intervention effectiveness), which empowered them to have the confidence to provide and access SRH information and services (self-efficacy).

Conclusions

Community-embedded interventions were acceptable as strong mechanisms for improving adolescents’ access to SRH in the communities. Policymakers should promote the community-embedded strategy for holistic health promotion of adolescents.