bluuebunny/crossref_metadata_2025 huggingface dataset:
The Efficacy and Safety of Direct Oral Anticoagulants versus Standard of Care in Patients without an Indication of Anti-Coagulants after Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Controlled Trials
Authors: Abuelazm Mohamed , Abdelazeem Basel , Katamesh Basant E. , Gamal Mohamed , Simhachalam Kutikuppala Lakshmi Venkata , Kheiri Babikir , Brašić James Robert , Paul Timir K.
Published: November 2022

Transcatheter aortic valve replacement (TAVR) is now considered the mainstay of aortic stenosis management; however, the optimal antithrombotic therapy in patent without indications for an oral anticoagulant (OAC) is yet to be identified. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of direct oral anticoagulant (DOAC) treatment versus the standard of care in patients without indications of OACs after TAVR. We synthesized randomized controlled trials (RCTs) from Web of Science, SCOPUS, EMBASE, PubMed, and Cochrane until 18 August 2022. We used the risk ratio (RR) for dichotomous outcomes with the corresponding 95% confidence interval (CI). We registered our protocol in PROSPERO with ID: CRD42022357027. Three RCTs with 2922 patients were identified. DOACs were significantly associated with higher incidence of all-cause mortality (RR: 1.68 with 95% CI [1.22, 2.30], p = 0.001), mortality due to non-cardiovascular causes (RR: 2.34 with 95% CI [1.36, 4.02], p = 0.002), and the composite outcome of death, myocardial infarction, or stroke (RR: 1.41 with 95% CI [1.13, 1.76], p = 0.002). However, DOACs were associated with decreased incidence of reduced leaflet motion (RLM) (RR: 0.19 with 95% CI [0.09, 0.41], p = 0.0001) and hypoattenuated leaflet thickening (HALT) (RR: 0.50 with 95% CI [0.36, 0.70], p = 0.0001). DOACs were effective to reduce RLM and HALT; however, the clinical effect of this is still controversial. DOACs were associated with worse efficacy and safety outcomes, including all-cause mortality. Further RCTs investigating the optimal antithrombotic regimen after TAVR.
Health-Related Quality of Life after Pediatric Traumatic Brain Injury: A Qualitative Comparison of Perspectives of Children and Adolescents after TBI and a Comparison Group without a History of TBI
Authors: Timmermann Dagmar , Krenz Ugne , Schmidt Silke , Lendt Michael , Salewski Christel , Brockmann Knut , von Steinbüchel Nicole
Published: November 2022

Background: The assessment of the impact of pediatric traumatic brain injury (TBI) on the health-related quality of life (HRQoL) of the children and adolescents affected can be ameliorated by a disease-specific instrument. Such an instrument does not yet exist. This qualitative study investigates how children and adolescents after TBI subjectively perceive their HRQoL and whether and how this differs from the perspective of individuals without a history of TBI. Methods: Eight problem-centered interviews were conducted with 11 children and adolescents around four years after mild TBI and with eight children and adolescents around three years after moderate to severe TBI. Nine problem-centered interviews were conducted with 25 participants without a history of TBI. The interviews were recorded and transcribed verbatim. The statements were assigned to inductively and deductively derived categories relevant to the HRQoL of children and adolescents after TBI and compared with those of individuals without a history of TBI. Results: The HRQoL of children and adolescents after TBI tended to display both structural and content-related differences, independently of TBI severity, on several HRQoL dimensions, in contrast to the comparison group. For example, participants after TBI reported a broader range of negative emotions (such as worry, sadness, shame, and guilt), permanent physical impairments, felt that they were treated differently from others, and perceived cognitive limitations. Conclusions: The results of this qualitative study identified HRQoL dimensions that are relevant to children and adolescents after TBI and underlined the need for the development of a disease-specific instrument.
Reversible Bronchial Obstruction in Primary Ciliary Dyskinesia
Authors: Levine Hagit , Bar-On Ophir , Nir Vered , West Nicole , Dizitzer Yotam , Mussaffi Huda , Prais Dario
Published: November 2022

Background: Inhaled bronchodilators are frequently used among patients with primary ciliary dyskinesia (PCD), although neither the effectiveness nor the prevalence of their use is known, due to the paucity of relevant studies. Methods: This is a retrospective analysis of pre- and post-bronchodilator spirometry results, of patients with PCD from two centers. Correlations were examined of bronchodilator response, with asthma and atopy markers. Results: Of 115 patients, 46 (40%) completed spirometry pre- and post-bronchodilation. Of these, 26 (56.5%) demonstrated reversible airway obstruction (increase in %FEV1 predicted ≥ 10%). Obstruction reversibility was not found to be associated with a family history of asthma, blood eosinophil level, elevated IgE, or atopy symptoms. Of the 46 patients who completed bronchodilator spirometry, 29 (63%) were regularly using bronchodilators and inhaled corticosteroids. Conclusions: More than half of patients with PCD presented with reversible airway obstruction, without any correlation to markers of personal or familial atopy. Inhaled bronchodilators and corticosteroid therapies are commonly used for treating PCD. Evaluating bronchodilator response should be considered, and its effectiveness should be further studied.
Dual Anti-Glomerular Basement Membrane and Anti-Neutrophil Cytoplasmic Antibodies—Positive Rapidly Progressive Glomerulonephritis with Rheumatoid Arthritis and Sjogren’s Syndrome: A Case Report and Literature Review
Authors: Cheng Ting , Zhi Huiwen , Liu Yunxiao , Zhang Shengxiao , Song Ziyi , Li Yafeng
Published: November 2022

Rapidly progressive glomerulonephritis (RPGN) is a life-threatening disease characterized by rapid progressive deterioration of renal function and extensive formation of crescents. Some antibodies tend to be positive, such as a perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) and anti-glomerular basement membrane (anti-GBM) antibodies, in most patients with the disease. However, cases of double positivity for the above antibodies are considered to be rare. In addition, both rheumatoid arthritis (RA) and Sjogren’s syndrome (SS) are deemed to be independent immune disorders that can cause renal impairment. Nevertheless, the association between RPGN and these two diseases has not been elucidated in previous studies. Here, we provide a case of RPGN with the concurrence of RA and SS characterized by double positivity in anti-GBM antibodies and p-ANCA. After aggressive treatment with cyclophosphamide, glucocorticoids, and plasma exchange, the patient improved significantly. Despite the malignant event of arteriovenous fistula rupture and bleeding during treatment, the patient survived with renal function recovery for the rest of the follow-up period.
Skin Manifestations in Patients with Selective Immunoglobulin E Deficiency
Authors: Picado César , García-Herrera Adriana , Hernández-Rodríguez José , Vlagea Alexandru , Pascal Mariona , Bartra Joan , Mascaró José
Published: November 2022

Selective immunoglobulin E deficiency (SIgED) is still an unrecognised primary immunodeficiency despite several observations supporting its existence. This study aimed to describe the skin manifestations associated with SIgED. We retrospectively assessed medical records of patients with SIgED, the diagnosis being based on serum IgE levels ≤2 Uk/L associated with normal serum levels of immunoglobulins G, M, and A. A total of 25 patients (24 female) with SIgED were included in the study. Eleven patients (44%) presented chronic spontaneous urticaria (CSU), five (20%) angioedema always associated with CSU, five erythema (20%), and six eczema (24%). Other, less frequent manifestations were lichen planus, anaphylactoid purpura, thrombocytopenic purpura, bullous pemphigoid, bullous pyoderma gangrenosum, and atypical skin lymphoproliferative infiltrate associated with reactive lymphadenopathy, chronic cholestasis, arthritis, and fibrosing mediastinitis. Fifteen patients (60%) had different types of associated autoimmune diseases, Hashimoto’s thyroiditis being the most frequent (n = 5, 20%), followed by arthritis (n = 4, 16%), autoimmune hepatitis, neutropenia, vitiligo, and Sjögren’s syndrome (n = 2, 8% each). Five malignancies were diagnosed in four patients (16%). An ultralow IgE serum level may be the only biomarker that reveals the presence of a dysregulated immune system in patients with a broad spectrum of skin manifestations.
Clinical Outcomes and Prolonged SARS-CoV-2 Viral Shedding in ICU Patients with Severe COVID-19 Infection and Nosocomial Bacterial Pneumonia: A Retrospective Cohort Study
Authors: Sun Chuan-Yen , Feng Jia-Yih , Huang Jhong-Ru , Shen Hisao-Chin , Chen Yuh-Min , Chen Wei-Chih , Yang Kuang-Yao
Published: November 2022

Objectives: This study explored the clinical outcomes and association of prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding in patients with severe coronavirus disease 2019 (COVID-19) infection who developed nosocomial pneumonia. Methods: This was a retrospective study conducted in a medical center in Taiwan. From May to September 2021, patients from four intensive care units were enrolled after SARS-CoV-2 was confirmed through quantitative polymerase chain reaction and all cases were compatible with the definitions of severe COVID-19 infection. Baseline characteristics, disease severity, clinical outcomes, and times of viral shedding were recorded. Results: A total of 72 patients were diagnosed as having severe COVID-19 infection and 30 developed nosocomial pneumonia, comprising hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP). The patients with severe COVID-19 infection and concomitant HAP/VAP had longer intensive care unit (ICU) stays and fewer ventilator-free days at Day 28. An independent risk factor for nosocomial pneumonia was a greater SOFA score at admission. Furthermore, the patients with severe COVID-19 infection who developed HAP/VAP had a significantly longer duration of SARS-CoV-2 shedding (19.50 days vs. 15.00 days, p = 0.006). Conclusions: Patients with severe COVID-19 infection who developed nosocomial pneumonia had longer SARS-CoV-2 shedding days, more complications, and worse outcomes.
Selection of Representative Questionnaire Items from the Asthma Control Test
Authors: Chang Min-Seok , Yu Iseul , Park Sunmin , Lee Ji-Ho , Lee Seok Jeong , Lee Won-Yeon , Yong Suk Joong , Jo Meounggun , Kim Sang-Ha
Published: November 2022

Asthma is a disease characterized by the appearance of transient or persistent symptoms in response to allergens, viral upper respiratory infections, and cold air. Asthma treatment aims to control, rather than cure, and digital systems can be useful in this regard. However, conventional assessment methods for asthma control are not suitable for digital healthcare. Therefore, we aimed to select representative questionnaire items suitable for digitally assessing the asthma control status. We analyzed the Asthma Control Test (ACT) and selected representative items. Throughout the year 2020, ACT results (2019 in total) collected from patients (>18 years old) with a principal diagnosis of asthma were analyzed. Individual questionnaire items were tested using Pearson’s correlation and receiver operating characteristic curves. Of the five questionnaire items, Q1, Q2, Q3, and Q5 yielded significant findings. Among these questionnaires, Q2 was the most descriptive and correlated questionnaire. Q5 was also significant but it was excluded since it was unable to apply to the digital health care system for asthma assessment method. The remaining three questionnaire items were selected and their sensitivity and specificity were assessed. Eight methods were analyzed, and the sum of scores of Q1–Q3 had the highest sensitivity and specificity (97% and 91%, respectively). The results suggested that, instead of the full items of ACT, the sum of Q1–Q3 can be used to assess the asthma control status. These findings will serve as the foundation for developing digital asthma control assessment tools.
Ventricular and Atrial Remodeling after Transcatheter Edge-to-Edge Repair: A Pilot Study
Authors: Albini Alessandro , Passiatore Matteo , Imberti Jacopo Francesco , Valenti Anna Chiara , Leo Giulio , Vitolo Marco , Coppi Francesca , Sgura Fabio Alfredo , Boriani Giuseppe
Published: November 2022

Background: The aim of this study was to determine the impact of transcatheter edge-to-edge repair (TEER) on left and right ventricular (LV, RV) and left and right atrial (LA, RA) remodeling according to the mechanism of mitral regurgitation (MR) and history of atrial fibrillation (AF). Methods: Twenty-four patients (mean age 78.54 years ± 7.64 SD; 62.5% males) underwent TEER at our center. All the patients underwent echocardiography 1.6 ± 0.9 months before the procedure and after 5.7 ± 3.5 months; functional MR accounted for 54% of cases. Results: Compared to baseline, a statistically significant improvement in LV end-diastolic diameter (LVEDD), LV indexed mass (ILVM), LV end-diastolic and end-systolic volumes (LVEDV, LVESV), indexed LA volume (iLAV), and morpho-functional RV parameters was recorded. LVEDD and LVEDV improved in primary MR cohort, whereas in secondary MR, a significant reduction in LVEDV and LVESV was found without a significant functional improvement. LA reverse remodeling was found in organic MR with a trend toward ameliorated function. Furthermore, a significant reduction of LA volumetry was detected only in patients without history of AF (AF baseline 51.4 mL/m2 IQR 45.6–62.5 mL/m2 f-u 48.9 mL/m2 IQR 42.9–59.2 mL/m2; p = 0.101; no AF baseline 43.5 mL/m2 IQR 34.2–60.5 mL/m2 f-u 42.0 mL/m2 IQR 32.0–46.2 mL/m2; p = 0.012). As regards right sections, the most relevant reverse remodeling was obtained in patients with functional MR with a baseline poorer RV function and more severe RA and RV dilation. Conclusion: TEER induces reverse remodeling involving both left and right chambers at mid-term follow-up. To deliver a tailored intervention, MR mechanism and history of AF should be considered in view of the impact on remodeling process.
Use of Autologous Platelet Rich Plasma (A-PRP) for Postpartum Perineal Repair Failure: A Case Report
Authors: Akhoundova Farida , Schumacher Fanny , Léger Marie , Berndt Sarah , Martinez de Tejada Begoña , Abdulcadir Jasmine
Published: November 2022

Perineal wound dehiscence is an uncommon but important postpartum complication. In many cases, it leads to extreme pain and urinary and defecation problems. For up to several weeks, it can interfere with the mother’s daily activity, affecting psychosexual health and body image. The best way to manage perineal wound breakdown (resuturing vs. spontaneous closure) after childbirth remains controversial. A-PRP is the autologous human plasma containing an increased platelet concentration, rich in growth factors, and mediators with hemostatic, anti-inflammatory, and antimicrobial properties. It accelerates the natural healing process. Even though A-PRP is widely used in orthopedics and dermatology, its use in gynecological injuries is limited. We describe here a case of a woman with postpartum perineal dehiscence treated with A-PRP with positive outcomes.
A Pan-Cancer Atlas of Differentially Interacting Hallmarks of Cancer Proteins
Authors: Kori Medi , Ozdemir Gullu Elif , Arga Kazim Yalcin , Sinha Raghu
Published: November 2022

Cancer hallmark genes and proteins orchestrate and drive carcinogenesis to a large extent, therefore, it is important to study these features in different cancer types to understand the process of tumorigenesis and discover measurable indicators. We performed a pan-cancer analysis to map differentially interacting hallmarks of cancer proteins (DIHCP). The TCGA transcriptome data associated with 12 common cancers were analyzed and the differential interactome algorithm was applied to determine DIHCPs and DIHCP-centric modules (i.e., DIHCPs and their interacting partners) that exhibit significant changes in their interaction patterns between the tumor and control phenotypes. The diagnostic and prognostic capabilities of the identified modules were assessed to determine the ability of the modules to function as system biomarkers. In addition, the druggability of the prognostic and diagnostic DIHCPs was investigated. As a result, we found a total of 30 DIHCP-centric modules that showed high diagnostic or prognostic performance in any of the 12 cancer types. Furthermore, from the 16 DIHCP-centric modules examined, 29% of these were druggable. Our study presents candidate systems’ biomarkers that may be valuable for understanding the process of tumorigenesis and improving personalized treatment strategies for various cancers, with a focus on their ten hallmark characteristics.
Measurement of Supply-and Demand-Side Endowment Effects and Analysis of Their Influencing Factors in Agricultural Land Transfer
Authors: Zhang Hanying , Li Jiafen , Shen Jinlong , Song Jianfeng
Published: November 2022

For a long time, the transference of land-contracting management rights was hindered by the unwillingness of farmers and inefficient use of farmland. The endowment effect is prevalent for farmers and is the main reason for the inhibited flow of farmland. However, recent studies have evaluated the endowment effect by treating buyers and sellers as one subject, which cannot be applied to individual land transfer transactions. Therefore, this paper redefines the endowment effect of farmland management rights by introducing market price as a reference point to evaluate the level of the supply- and demand-side endowment effects. The supply-side endowment effect is the gap between sellers’ willingness to accept and the market rent; the demand-side endowment effect is the gap between the market rent and buyers’ willingness to pay. In the empirical study, two multiple regression models are designed to measure the respective factors affecting the supply and demand sides, employing farm household survey data in Shaanxi Province. The obtained results reveal that the agricultural land transfer in Shaanxi Province is at a normal proportional level, and the supply- and demand-side endowment effects in agricultural land transfer are prevalent. The dependence of people on goods and the substitutability of the goods significantly affect the endowment effect of supply-side farmers, while the perception of expected income, cost and risk impact the endowment effect of demand-side farmers. Based on this, some policy recommendations are proposed to offset the influence of the endowment effect, thus promoting the development of the farmland transfer market.
Higenamine, Anti-Doping, and Plant-Based Cuisine: A Legal Analysis of Higenamine in Sport Anti-Doping Systems
Authors: Zaksaite Salomeja
Published: November 2022

Current anti-doping policy seeks to protect honest athletes from biochemically overeducated colleagues. However, there is a question of whether the present policy has gone too far. This article illustrates the ambiguity of the anti-doping policy in the context of a particular plant-based substance (i.e., higenamine) by providing certain case studies. In such cases, the process of proof requires the continuous checking of suppositions since an athlete must establish how the prohibited substance could have entered his or her body. This obligation implies that an athlete and the defending team must have legal, medical, dietary, and biochemical knowledge. However, even with all precautions, it is still possible to fail an anti-doping test and be severely punished because it is almost impossible to trace all the sources that caused the prohibited substance to enter the athlete’s body.
Applications and Pharmacological Properties of Cactus Pear (Opuntia spp.) Peel: A Review
Authors: Manzur-Valdespino Salvador , Arias-Rico José , Ramírez-Moreno Esther , Sánchez-Mata María de Cortes , Jaramillo-Morales Osmar Antonio , Angel-García Julieta , Zafra-Rojas Quinatzin Yadira , Barrera-Gálvez Rosario , Cruz-Cansino Nelly del Socorro
Published: November 2022

Nowadays, there is a growing interest in the exploitation of by-products from fruits and vegetables, generated from industrial processing or human feeding. Residues of popularly consumed fruits such as orange, lemon, banana, pomegranate, among others, have been widely described and studied; however, cactus pear (Opuntia spp.) residues, as a locally consumed product, have been forgotten. The whole fruit can be divided into the edible portion (pulp) and the non-edible portion (seeds and peel). Several studies mainly focus on the characteristics of the edible portion or in the whole fruit, ignoring by-products such as peels, which are rich in compounds such as phenols, flavonoids and dietary fiber; they have also been proposed as an alternative source of lipids, carbohydrates and natural colorants. Some uses of the peel have been reported as a food additives, food supplements, as a source of pectins and for wastewater treatment; however, there have not been any deep investigations of the characteristics and potential uses of the cactus pear peel (CPP). The aim of the present paper is to provide an overview of the current research on CPP. CPP has many bio-active compounds that may provide health benefits and may also be useful in pharmaceutical, food and manufacturing industries; however, greater research is needed in order to gain thorough knowledge of the possibilities of this by-product.
Prokaryotic Diversity of Ruminal Content and Its Relationship with Methane Emissions in Cattle from Kazakhstan
Authors: Daugaliyeva Aida , Daugaliyeva Saule , Ashanin Alexander , Beltramo Chiara , Mamyrova Latipa , Yessembekova Zinagul , Peletto Simone
Published: November 2022

In this study, we analyzed the microbial composition of the rumen contents of cattle from Kazakhstan. Specifically, samples of the liquid and solid fractions of the rumen were collected to determine the quantitative and qualitative composition of methanogenic archaea. Cattle were six steers receiving hay-concentrate feeding. Methane emission was determined by repeated measurements for each animal. Rumen samples were then taken from fistulas and analyzed using 16S metabarcoding via Next-Generation Sequencing (NGS). The difference between the rumen fractions was investigated, resulting in differential distribution of the families Streptococccaceae, Lactobacillaceae, Desulfobulbaceae, and Succinivibrionaceae, which were more abundant in the liquid fraction, while Thalassospiraceae showed a higher presence in the solid fraction. These differences can be explained by the fact that fibrolytic bacteria are associated with the solid fraction compared to the liquid. A relationship between methane emission and methanogenic microbiota was also observed. Steers producing more methane showed microbiota richer in methanogens; specifically, most Mathanobacteriaceae resided in the liquid fraction and solid fraction of animals 1 and 6, respectively. The same animals carried most of the Methanobrevibacter and Methanosphaera genera. On the contrary, animals 2, 3, and 5 hosted a lower amount of methanogens, which also agreed with the data on methane emissions. In conclusion, this study demonstrated a relationship between methane emission and the content of methanogenic archaea in different rumen fractions collected from cattle in Kazakhstan. As a result of the studies, it was found that the solid fraction of the rumen contained more genera of methanogens than the liquid fraction of the rumen. These results prove that taking rumen contents through a fistula is more useful than taking it through a probe. The presented data may be of interest to scientists from all over the world engaged in similar research in a comparative aspect.
Mixed EHL Problems: An Efficient Solution to the Fluid–Solid Coupling Problem with Consideration of Elastic Deformation and Cavitation
Authors: Gu Chunxing , Zhang Di , Jiang Xiaohui , Meng Xianghui , Wang Shuwen , Ju Pengfei , Liu Jingzhou
Published: November 2022

For transient mixed Elastohydrodynamic lubrication (EHL) problems, a novel solution is required to predict friction loss and wear in sliding or rolling parts. However, existing solutions have numerous limitations. In general, the lower the oil film thickness is, the more serious the non-linear problem is. This paper presents an efficient solution to tackle the non-linearity of the mixed EHL problem. The elastic deformation in the fluid–solid iteration coupling problem is divided into two parts: One is induced by the hydrodynamic pressure. This part of the deformation is obtained by the unsteady EHL-FBNS (Fischer–Burmeister–Newton–Schur) solver by considering both mass-conserving cavitation and elastic deformation. The other part of the deformation is introduced by the asperity contact pressure. It can be obtained by the Newton–Raphson method. After some limited iterations, the mixed EHL problems can be solved by evaluating the residual total pressure (including hydrodynamic pressure and asperity contact pressure). The proposed methodology was validated against the results from the published literature and applied to characterize the tribological performance of point contact with moving texturing. It appears that the developed method can be effectively used for tracking the tribological behavior of friction pairs.
An Investigation of the Performance and Internal Flow of Variable Nozzle Turbines with Split Sliding Guide Vanes
Authors: Yang Dengfeng , Wang Kai , Wang Huaiyu , Zhang Qian , Lei Xinguo , Hu Leon
Published: November 2022

In order to effectively weaken the leakage flow and shock intensity of traditional “swing” type guide vanes in a variable nozzle turbine, a new flow control device named the “split sliding guide vane” (SSGV) is studied in the present work. Steady and unsteady calculations were carried out on both the SSGV and base model at 10%, 40%, and 100% open positions. The shock test was performed to verify the accuracy of the numerical method. The results showed that at 10%, 40%, and 100% open positions, the leakage flow of the SSGV was 43%, 51%, and 40% of that of the base model, respectively. When 10% open, the turbine efficiency increased by 12%, compared with the base model, since the SSGV could effectively inhibit the clearance leakage flow. Due to the increased distance between the rotor and guide vane, the shock intensity of the SSGV was only 52% of that of the base model when 40% was open. The SSGV could reduce the static pressure loss on the guide vane pressure surface, but for the guide vane suction surface, the static pressure distribution appeared in a “W” shape due to the influence of the vane profile. Finally, the flow in the rotor was studied, which showed that the weakening of the shock and reduction of the clearance leakage flow in the guide vane were also beneficial for the strength of downstream rotor blades.
On Improving Adaptive Problem Decomposition Using Differential Evolution for Large-Scale Optimization Problems
Authors: Vakhnin Aleksei , Sopov Evgenii , Semenkin Eugene
Published: November 2022

Modern computational mathematics and informatics for Digital Environments deal with the high dimensionality when designing and optimizing models for various real-world phenomena. Large-scale global black-box optimization (LSGO) is still a hard problem for search metaheuristics, including bio-inspired algorithms. Such optimization problems are usually extremely multi-modal, and require significant computing resources for discovering and converging to the global optimum. The majority of state-of-the-art LSGO algorithms are based on problem decomposition with the cooperative co-evolution (CC) approach, which divides the search space into a set of lower dimensional subspaces (or subcomponents), which are expected to be easier to explore independently by an optimization algorithm. The question of the choice of the decomposition method remains open, and an adaptive decomposition looks more promising. As we can see from the most recent LSGO competitions, winner-approaches are focused on modifying advanced DE algorithms through integrating them with local search techniques. In this study, an approach that combines multiple ideas from state-of-the-art algorithms and implements Coordination of Self-adaptive Cooperative Co-evolution algorithms with Local Search (COSACC-LS1) is proposed. The self-adaptation method tunes both the structure of the complete approach and the parameters of each algorithm in the cooperation. The performance of COSACC-LS1 has been investigated using the CEC LSGO 2013 benchmark and the experimental results has been compared with leading LSGO approaches. The main contribution of the study is a new self-adaptive approach that is preferable for solving hard real-world problems because it is not overfitted with the LSGO benchmark due to self-adaptation during the search process instead of a manual benchmark-specific fine-tuning.
An Evaluation of Modern Accelerator-Based Edge Devices for Object Detection Applications
Authors: Kang Pilsung , Somtham Athip
Published: November 2022

Edge AI is one of the newly emerged application domains where networked IoT (Internet of Things) devices are deployed to perform AI computations at the edge of the cloud environments. Today’s edge devices are typically equipped with powerful accelerators within their architecture to efficiently process the vast amount of data generated in place. In this paper, we evaluate major state-of-the-art edge devices in the context of object detection, which is one of the principal applications of modern AI technology. For our evaluation study, we choose recent devices with different accelerators to compare performance behavior depending on different architectural characteristics. The accelerators studied in this work include the GPU and the edge version of the TPU, and these accelerators can be used to boost the performance of deep learning operations. By performing a set of major object detection neural network benchmarks on the devices and by analyzing their performance behavior, we assess the effectiveness and capability of the modern edge devices accelerated by a powerful parallel hardware. Based on the benchmark results in the perspectives of detection accuracy, inference latency, and energy efficiency, we provide a latest report of comparative evaluation for major modern edge devices in the context of the object detection application of the AI technology.
Identification and Characterization of Novel Mutations in Chronic Kidney Disease (CKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Saudi Subjects by Whole-Exome Sequencing
Authors: Alzahrani Othman R. , Alatwi Hanan E. , Alharbi Amnah A. , Alessa Abdulrahman H. , Al-Amer Osama M. , Alanazi Abeer F. R. , Shams Anwar M. , Alomari Esra’a , Naser Abdallah Y. , Alzahrani Faisal a. , Hosawi Salman , Alghamdi Saeed M. , Abdali Wed A. , Elfaki Imadeldin , Hawsawi Yousef M.
Published: November 2022

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a condition usually caused by a single gene mutation and manifested by both renal and extrarenal features, eventually leading to end-stage renal disease (ESRD) by the median age of 60 years worldwide. Approximately 89% of ADPKD patients had either PKD1 or PKD2 gene mutations. The majority (85%) of the mutations are in the PKD1 gene, especially in the context of family history. Objectives: This study investigated the genetic basis and the undiscovered genes that are involved in ADPKD development among the Saudi population. Materials and Methods: In this study, 11 patients with chronic kidney disease were enrolled. The diagnosis of ADPKD was based on history and diagnostic images: CT images include enlargement of renal outlines, renal echogenicity, and presence of multiple renal cysts with dilated collecting ducts, loss of corticomedullary differentiation, and changes in GFR and serum creatinine levels. Next-generation whole-exome sequencing was conducted using the Ion Torrent PGM platform. Results: Of the 11 Saudi patients diagnosed with chronic kidney disease (CKD) and ADPKD, the most common heterozygote nonsynonymous variant in the PKD1 gene was exon15: (c.4264G > A). Two missense mutations were identified with a PKD1 (c.1758A > C and c.9774T > G), and one patient had a PKD2 mutation (c.1445T > G). Three detected variants were novel, identified at PKD1 (c.1758A > C), PKD2L2 (c.1364A > T), and TSC2 (deletion of a’a at the 3’UTR, R1680C) genes. Other variants in PKD1L1 (c.3813_381 4delinsTG) and PKD1L2 (c.404C > T) were also detected. The median age of end-stage renal disease for ADPK patients in Saudi Arabia was 30 years. Conclusion: This study reported a common variant in the PKD1 gene in Saudi patients with typical ADPKD. We also reported (to our knowledge) for the first time two novel missense variants in PKD1 and PKD2L2 genes and one indel mutation at the 3’UTR of the TSC2 gene. This study establishes that the reported mutations in the affected genes resulted in ADPKD development in the Saudi population by a median age of 30. Nevertheless, future protein–protein interaction studies to investigate the influence of these mutations on PKD1 and PKD2 functions are required. Furthermore, large-scale population-based studies to verify these findings are recommended.
The Combined Effects of the Membrane and Flow Channel Development on the Performance and Energy Footprint of Oil/Water Emulsion Filtration
Authors: Barambu Nafiu Umar , Bilad Muhammad Roil , Shamsuddin Norazanita , Samsuri Shafirah , Nordin Nik Abdul Hadi Md , Arahman Nasrul
Published: November 2022

Membrane filtration is a promising technology for oil/water emulsion filtration due to its excellent removal efficiency of microdroplets of oil in water. However, its performance is highly limited due to the fouling-prone nature of oil droplets on hydrophobic membranes. Membrane filtration typically suffers from a low flux and high pumping energy. This study reports a combined approach to tackling the membrane fouling challenge in oil/water emulsion filtration via a membrane and a flow channel development. Two polysulfone (PSF)-based lab-made membranes, namely PSF- PSF-Nonsolvent induced phase separation (NIPS) and PSF-Vapor-induced phase separation (VIPS), were selected, and the flow channel was modified into a wavy path. They were assessed for the filtration of a synthetic oil/water emulsion. The results showed that the combined membrane and flow channel developments enhanced the clean water permeability with a combined increment of 105%, of which 34% was attributed to the increased effective filtration area due to the wavy flow channel. When evaluated for the filtration of an oil/water emulsion, a 355% permeability increment was achieved from 43 for the PSF-NIPS in the straight flow channel to 198 L m−2 h−1 bar−1 for the PSF-VIPS in the wavy flow channel. This remarkable performance increment was achieved thanks to the antifouling attribute of the developed membrane and enhanced local mixing by the wavy flow channel to limit the membrane fouling. The increase in the filtration performance was translated into up to 78.4% (0.00133 vs. 0.00615 kWh m−3) lower in pumping energy. The overall findings demonstrate a significant improvement by adopting multi-pronged approaches in tackling the challenge of membrane fouling for oil/water emulsion filtration, suggesting the potential of this approach to be applied for other feeds.
The Effect of Thermal Treatment on Microstructure and Thermal-Induced Martensitic Transformations in Ni44Fe19Ga27Co10 Single Crystals
Authors: Timofeeva Ekaterina E. , Panchenko Elena Yu. , Zherdeva Maria V. , Tokhmetova Aida B. , Surikov Nikita Yu. , Chumlyakov Yuriy I. , Karaman Ibrahim
Published: November 2022

Heat treatments of single crystals of Ni44Fe19Ga27Co10 (at.%) shape memory alloys cause various microstructures of the high-temperature phase. The nanodomain structure, consisting of regions of the L21- and B2-phases, and nanosized particles are the main parameters that change during heat treatments and determine the mechanism of nucleation and growth of martensite crystals, the size of thermal-induced martensite lamellae, the temperature Ms, and the temperature intervals of the martensitic transformation. In the as-grown single crystals, the high-temperature phase has only the L21-structure and the MT occurs at low (Ms = 125 K) temperatures due to the motion of the practically single interphase boundary in narrow temperature ranges of 3–7 K. The reduction in the volume fraction of the L21-phase to 40% and the formation of nanodomains (20–50 nm) of the L21-and B2-phases due to annealing at 1448 K for 1 h with quenching causes an increase in the MT temperatures by 80 K. The MT occurs in wide temperature ranges of 40–45 K because of multiple nucleation of individual large (300–500 µm) martensite lamellae and their growth. After aging at 773 K for 1 h, the precipitation of nanosized particles of the ω-phase in such a structure additionally increases the MT temperatures by 45 K. The MT occurs due to the multiple nucleation of packets of small (20–50 μm) martensite lamellae.
Components of the Shear Modulus and Their Dependence on Temperature and Plastic Deformation of a Metallic Glass
Authors: Makarov Andrei , Kretova Marina , Afonin Gennadii , Kobelev Nikolai , Khonik Vitaly
Published: November 2022

High-precision measurements of the temperature dependences of the high-frequency shear modulus G performed on as-cast, preannealed and predeformed Zr46Cu45Al7Ti2 bulk metallic glass allowed us to determine, for the first time, the harmonic, anharmonic, electronic and relaxation components of G. The dependence of anharmonic, electronic and relaxation components on temperature and preliminary inhomogeneous (localized) plastic deformation was investigated. It is found that plastic deformation results in a significant change in these components. We showed that the increase in the integral relaxation contribution to the shear modulus with an increase in plastic deformation can be quantitatively described within the framework of the interstitialcy theory. It is also found that plastic deformation simultaneously leads to an increase in the anharmonic and decrease in the electronic components of the shear modulus.
Effects of Softening Dry Food with Water on Stress Response, Intestinal Microbiome, and Metabolic Profile in Beagle Dogs
Authors: Zhang Limeng , Yang Kang , Jian Shiyan , Xin Zhongquan , Wen Chaoyu , Zhang Lingna , Huang Jian , Deng Baichuan , Deng Jinping
Published: November 2022

Softening dry food with water is believed to be more beneficial to the intestinal health and nutrients absorption of dogs by some owners, but there appears to be little scientific basis for this belief. Thus, this study aimed to compare feeding dry food (DF) and water-softened dry food (SDF) on stress response, intestinal microbiome, and metabolic profile in dogs. Twenty healthy 5-month-old beagle dogs were selected and divided into two groups according to their gender and body weight using a completely randomized block design. Both groups were fed the same basal diet, with one group fed DF and the other fed SDF. The trial lasted for 21 days. The apparent total tract digestibility (ATTD) of nutrients, inflammatory cytokines, stress hormones, heat shock protein-70 (HSP-70), fecal microbiota, short-chain fatty acids (SCFAs), branch-chain fatty acids (BCFAs), and metabolomics were measured. Results showed that there was no significant difference in body weight, ATTD, and SCFAs between the DF and SDF groups (p > 0.05), whereas feeding with SDF caused a significant increase in serum cortisol level (p < 0.05) and tended to have higher interleukin-2 (p = 0.062) and HSP-70 (p = 0.097) levels. Fecal 16S rRNA gene sequencing found that the SDF group had higher alpha diversity indices (p < 0.05). Furthermore, the SDF group had higher levels of Streptococcus, Enterococcus, and Escherichia_Shigella, and lower levels of Faecalibacterium (p < 0.05). Serum and fecal metabolomics further showed that feeding with SDF significantly influenced the purine metabolism, riboflavin metabolism, and arginine and proline metabolism (p < 0.05). Overall, feeding with SDF caused higher cortisol level and generated effects of higher intestinal microbial diversity in dogs, but it caused an increase in some pathogenic bacteria, which may result in intestinal microbiome disturbance and metabolic disorder in dogs. In conclusion, feeding with SDF did not provide digestive benefits but caused some stress and posed a potential threat to the intestinal health of dogs. Thus, SDF is not recommended in the feeding of dogs.
Identification of Serum Metabolites for Predicting Chronic Kidney Disease Progression according to Chronic Kidney Disease Cause
Authors: Kang Eunjeong , Li Yufei , Kim Bora , Huh Ki Young , Han Miyeun , Ahn Jung-Hyuck , Sung Hye Youn , Park Yong Seek , Lee Seung Eun , Lee Sangjun , Park Sue K. , Cho Joo-Youn , Oh Kook-Hwan
Published: November 2022

Early detection and proper management of chronic kidney disease (CKD) can delay progression to end-stage kidney disease. We applied metabolomics to discover novel biomarkers to predict the risk of deterioration in patients with different causes of CKD. We enrolled non-dialytic diabetic nephropathy (DMN, n = 124), hypertensive nephropathy (HTN, n = 118), and polycystic kidney disease (PKD, n = 124) patients from the KNOW-CKD cohort. Within each disease subgroup, subjects were categorized as progressors (P) or non-progressors (NP) based on the median eGFR slope. P and NP pairs were randomly selected after matching for age, sex, and baseline eGFR. Targeted metabolomics was performed to quantify 188 metabolites in the baseline serum samples. We selected ten progression-related biomarkers for DMN and nine biomarkers each for HTN and PKD. Clinical parameters showed good ability to predict DMN (AUC 0.734); however, this tendency was not evident for HTN (AUC 0.659) or PKD (AUC 0.560). Models constructed with selected metabolites and clinical parameters had better ability to predict CKD progression than clinical parameters only. When selected metabolites were used in combination with clinical indicators, random forest prediction models for CKD progression were constructed with AUCs of 0.826, 0.872, and 0.834 for DMN, HTN, and PKD, respectively. Select novel metabolites identified in this study can help identify high-risk CKD patients who may benefit from more aggressive medical treatment.
Genesis of Metal Sulfides and Its Significance on Graphite Mineralization in the Huangyangshan Graphite Deposit, East Junggar, Xinjiang Province, China
Authors: Ren Yunsheng , Li Jingmou , Sun Xinhao , Li Zuowu , Sun Zhenjun
Published: November 2022

The Huangyangshan super-large graphite deposit is located in the Qitai area of East Junggar in Xinjiang Province, China. This deposit is well known for its distinguishing properties, including the alkaline granite complex that hosts the graphite ore, the dominantly orbicular structure developed in the graphite ore, and the association of graphite with metal sulfides in the orbicular ore. This study aims to determine the genetic relationship between graphite and metal sulfides in order to better understand the graphite mineralization process of the Huangyangshan deposit. The methods applied in the study include X-ray micro-CT scanning and scanning electron microscopy (SEM) analyses of the orbicular graphite ore and in situ inductive laser ablation-coupled plasma mass spectrometry (LA-ICP-MS) trace element analyses of the pyrrhotite and chalcopyrite associated with the graphite. The analytical results show that the graphite ore is composed of crystalline graphite, K-feldspar, albite, quartz, biotite, amphibole, and metal sulfides. The metal sulfides in the orbicular ore include pyrite, pyrrhotite, pentlandite, and chalcopyrite. According to the color, crystalline shape, texture, and occurrence, pyrrhotite can be classified into four types (I, II, III, and IV), and chalcopyrite into two types (I and II), of which types I, II, and III pyrrhotite and type I chalcopyrite have a close genetic relationship with graphite. The granular types (I, II, and III) of pyrrhotite are enriched in Co, Ni, Se, Ge, and Te and are depleted in As, Sb, Ag, and Au; they also have a high value of Co/Ni, indicating that these types of pyrrhotite have a magmatic origin. Low values of Co/Ni suggest that type IV pyrrhotite has a hydrothermal origin. The similar contents of Co and Ni and the values of Co/Ni compared with the chalcopyrite from the magmatic Co–Ni sulfide deposits imply that type I chalcopyrite has a magmatic origin. In summary, the metal sulfides of the Huangyangshan deposit are genetically related to graphite mineralization and formed predominantly by magmatic processes.
Structure Formation and Regulation of Au Nanoparticles in LiTaO3 by Ion Beam and Thermal Annealing Techniques
Authors: Liu Yong , Han Xinqing , Zhao Jinhua , Sun Jian , Huang Qing , Wang Xuelin , Liu Peng
Published: November 2022

The size uniformity and spatial dispersion of nanoparticles (NPs) formed by ion implantation must be further improved due to the characteristics of the ion implantation method. Therefore, specific swift heavy ion irradiation and thermal annealing are combined in this work to regulate the size and spatial distributions of embedded Au NPs formed within LiTaO3 crystals. Experimental results show that small NPs migrate to deeper depths induced by 656 MeV Xe35+ ion irradiation. During thermal annealing, the growth of large Au NPs is limited due to the reductions in the number of small Au NPs, and the migrated Au NPs aggregate at deeper depths, resulting in a more uniform size distribution and an increased spatial distribution of Au NPs. The present work presents a novel method to modify the size and spatial distributions of embedded NPs.
Nanoscale Waveguide Beam Splitter in Quantum Technologies
Authors: Makarov Dmitry , Makarova Ksenia , Tsykareva Yuliana , Kapustin Sergey , Kharlamova Anastasia , Gusarevich Eugeny , Goshev Andrey
Published: November 2022

Usually in quantum optics, the theory of large- and small-scale waveguide beam splitters is the same. In this paper, it is shown that the theory of the nanoscale waveguide beamsplitter has a significant difference from a similar device, but of a larger scale. It is shown that the previously known theory of the waveguide beam splitter is a particular case of the theory presented here. The wave function at the output ports of the nanoscale beam splitter is analyzed. The results obtained are sensitive to the size of the beam splitter, the coupling parameter of the two waveguides, and the degree of nonmonochromaticity of the photons entering the first and second ports of the beam splitter. The results are important for quantum technologies using a nanosized beam splitter.