bluuebunny/crossref_metadata_2025 huggingface dataset:
Table 3 from Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer
Authors: Loo Jessica , Robbins Marc , McNeil Carson , Yoshitake Tadayuki , Santori Charles , Shan Chuanhe (Jay) , Vyawahare Saurabh , Patel Hardik , Wang Tzu Chien , Findlater Robert , Steiner David F. , Rao Sudha , Gutierrez Michael , Wang Yang , Sanchez Adrian C. , Yin Raymund , Velez Vanessa , Sigman Julia S. , Coutinho de Souza Patricia , Chandrupatla Hareesh , Scott Liam , Weaver Shamira S. , Lee Chung-Wein , Rivlin Ehud , Goldenberg Roman , Couto Suzana S. , Cimermancic Peter , Wong Pok Fai
Published: January 2025

Pearson’s correlation (95% confidence interval) between measurements on real and virtual stains obtained from the cell segmentation–based analysis in Visiopharm software for PanCK, DAPI, PD-L1, CD3, and CD8 on testing slides. Analysis was performed according to three different definitions of the region of interest
Supplementary Table S1 from Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer
Authors: Loo Jessica , Robbins Marc , McNeil Carson , Yoshitake Tadayuki , Santori Charles , Shan Chuanhe (Jay) , Vyawahare Saurabh , Patel Hardik , Wang Tzu Chien , Findlater Robert , Steiner David F. , Rao Sudha , Gutierrez Michael , Wang Yang , Sanchez Adrian C. , Yin Raymund , Velez Vanessa , Sigman Julia S. , Coutinho de Souza Patricia , Chandrupatla Hareesh , Scott Liam , Weaver Shamira S. , Lee Chung-Wein , Rivlin Ehud , Goldenberg Roman , Couto Suzana S. , Cimermancic Peter , Wong Pok Fai
Published: January 2025

Supplementary Table S1
Supplementary Material 4 from Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer
Authors: Loo Jessica , Robbins Marc , McNeil Carson , Yoshitake Tadayuki , Santori Charles , Shan Chuanhe (Jay) , Vyawahare Saurabh , Patel Hardik , Wang Tzu Chien , Findlater Robert , Steiner David F. , Rao Sudha , Gutierrez Michael , Wang Yang , Sanchez Adrian C. , Yin Raymund , Velez Vanessa , Sigman Julia S. , Coutinho de Souza Patricia , Chandrupatla Hareesh , Scott Liam , Weaver Shamira S. , Lee Chung-Wein , Rivlin Ehud , Goldenberg Roman , Couto Suzana S. , Cimermancic Peter , Wong Pok Fai
Published: January 2025

Supplementary Material 4
Supplementary Material 2 from Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer
Authors: Loo Jessica , Robbins Marc , McNeil Carson , Yoshitake Tadayuki , Santori Charles , Shan Chuanhe (Jay) , Vyawahare Saurabh , Patel Hardik , Wang Tzu Chien , Findlater Robert , Steiner David F. , Rao Sudha , Gutierrez Michael , Wang Yang , Sanchez Adrian C. , Yin Raymund , Velez Vanessa , Sigman Julia S. , Coutinho de Souza Patricia , Chandrupatla Hareesh , Scott Liam , Weaver Shamira S. , Lee Chung-Wein , Rivlin Ehud , Goldenberg Roman , Couto Suzana S. , Cimermancic Peter , Wong Pok Fai
Published: January 2025

Supplementary Material 2
Supplementary Figure S6 from Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer
Authors: Loo Jessica , Robbins Marc , McNeil Carson , Yoshitake Tadayuki , Santori Charles , Shan Chuanhe (Jay) , Vyawahare Saurabh , Patel Hardik , Wang Tzu Chien , Findlater Robert , Steiner David F. , Rao Sudha , Gutierrez Michael , Wang Yang , Sanchez Adrian C. , Yin Raymund , Velez Vanessa , Sigman Julia S. , Coutinho de Souza Patricia , Chandrupatla Hareesh , Scott Liam , Weaver Shamira S. , Lee Chung-Wein , Rivlin Ehud , Goldenberg Roman , Couto Suzana S. , Cimermancic Peter , Wong Pok Fai
Published: January 2025

Supplementary Figure S6
Supplementary Figure S4 from Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer
Authors: Loo Jessica , Robbins Marc , McNeil Carson , Yoshitake Tadayuki , Santori Charles , Shan Chuanhe (Jay) , Vyawahare Saurabh , Patel Hardik , Wang Tzu Chien , Findlater Robert , Steiner David F. , Rao Sudha , Gutierrez Michael , Wang Yang , Sanchez Adrian C. , Yin Raymund , Velez Vanessa , Sigman Julia S. , Coutinho de Souza Patricia , Chandrupatla Hareesh , Scott Liam , Weaver Shamira S. , Lee Chung-Wein , Rivlin Ehud , Goldenberg Roman , Couto Suzana S. , Cimermancic Peter , Wong Pok Fai
Published: January 2025

Supplementary Figure S4
Supplementary Figure S1 from Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer
Authors: Loo Jessica , Robbins Marc , McNeil Carson , Yoshitake Tadayuki , Santori Charles , Shan Chuanhe (Jay) , Vyawahare Saurabh , Patel Hardik , Wang Tzu Chien , Findlater Robert , Steiner David F. , Rao Sudha , Gutierrez Michael , Wang Yang , Sanchez Adrian C. , Yin Raymund , Velez Vanessa , Sigman Julia S. , Coutinho de Souza Patricia , Chandrupatla Hareesh , Scott Liam , Weaver Shamira S. , Lee Chung-Wein , Rivlin Ehud , Goldenberg Roman , Couto Suzana S. , Cimermancic Peter , Wong Pok Fai
Published: January 2025

Supplementary Figure S1
A Case of Myeloproliferative Neoplasm with Eosinophilia Associated with PCM1-JAK2 Rearrangement
Authors: Zhou Wen , Guo Xiaojia , Liu Yang , Hao Zhengdong , Chu Songlin , Zhang Liansheng , Li Lijuan
Published: January 2025

Introduction: The PCM1-JAK2 rearrangement is generated through the t(8; 9)(p22; p24) translocation event. The myeloid/lymphoid neoplasms with eosinophilia (MLN-eo) with PCM1-JAK2 rearrangement is the common types of MLN-eo with tyrosine kinase fusion genes (MLN-Eo-tk). MLN-Eo with PCM1-JAK2 rearrangement is a rare disease with a poor prognosis and no unified treatment guidelines. The response of disease to ruxolitinib may be transient and it may only serve as a temporary treatment prior to transplantation. Case Presentation: We report 1 patient diagnosed with MLN-Eo with PCM1-JAK2 rearrangement who exhibited resistance to ruxolitinib, subsequently received pegylated interferon (Peg-IFN) and lenalidomide. The Peg-IFN was discontinued due to adverse effects; the patient has been receiving lenalidomide monotherapy for a duration exceeding 2 years, achieving complete hematologic remission and molecular response, significant amelioration of symptoms, as well as regression of hepatosplenomegaly. Conclusion: A case of MLN-Eo with PCM1-JAK2 rearrangement underwent continuous oral lenalidomide monotherapy for over 2 years. The patient achieved complete hematologic remission and molecular response during the long-term follow-up; however, a complete molecular remission was not attained. The underlying mechanism of lenalidomide in these diseases necessitates further comprehensive investigation through fundamental research and clinical trials.
Análises psicométricas das características psicológicas no desenvolvimento da excelência de jovens atletas
Authors: Sarti Ariane Caroline , Quinaud Ricardo Teixeira , Possamai Kauana , Kós Luisa , Gonçalves Carlos E. , Paes Roberto , Gonçalves Humberto M.
Published: January 2025

The present study aimed to validate the Psychological Characteristics in the Development of Excellence Questionnaire to the Brazilian culture, based on the Bayesian exploratory and confirmatory factor analysis. Initially, the conceptual and semantic translation of the questionnaire was carried out as well as cognitive interviews. The questionnaire was applied in two independent samples (305 athletes and 495 athletes). Based on the Bayesian exploratory factor analysis, it was possible to observe evidence of factor structure composed of 5 factors and 33 items. The Bayesian confirmatory factor analysis confirmed the 5-factor structure (adverse response to failure, mental visualization, mental preparation for performance, active coping and lack of self-control), however with the presence of 24 items. For the Brazilian context, the questionnaire showed a reduction in items probably due to the different contexts and cultural differences in which the questionnaire was initially validated, as well as the use of Bayesian methods, which are more rigorous in items’ retention. We present a valid questionnaire for the Brazilian context, which can be a great ally during the development process of young athletes, contributing to the increase of skills and psychological characteristics and offering support to coaches in this process.
Desempenho de jovens nadadoras em provas de curta, média e longa distância
Authors: Vitor Fabrício de Mello , Böhme Maria Tereza Silveira
Published: January 2025

O objetivo deste estudo foi explicar o papel dos parâmetros antropométricos, fisiológicos e técnicos controlados pela idade cronológica e pelo estado maturacional no desempenho de jovens nadadoras (n=42; 13.3±0.57 anos) em provas de curta (100 metros), média (200 metros) e longa distância (800 metros). Uma análise de regressão múltipla hierárquica (método stepwise) foi utilizada para examinar a variância de todas as provas. A potência anaeróbica e a velocidade crítica explicaram respectivamente, 92% (p<0.05), 84% (p<0.05) e 99 % (p<0.05) da variância na velocidade média dos 100 metros, 200 metros e 800 metros nado crawl. Apesar dos parâmetros técnicos de nado não serem incluídos nos modelos explanatórios, o índice de eficiência de nado mostrou altas correlações com 100 metros (r=0.85, p<0.01), 200 metros (r=0.69, p<0.01) e 800 metros (r=0.72, p<0.01). O desempenho de jovens nadadoras em provas de curta, média e longa distância é explicado predominantemente por componentes fisiológicos e em menor grau pela eficiência técnica.
Capacidade de sprints repetidos em jovens futebolistas: efeitos da maturação esquelética, crescimento e aptidão aeróbia
Authors: Teixeira Anderson Santiago , Silva Juliano Fernandes da , Salvador Paulo Cesar do Nascimento , Santos Priscila Cristina dos , Guglielmo Luiz Guilherme Antonacci
Published: January 2025

O objetivo do presente estudo foi determinar a contribuição da capacidade de endurance intermitente, idade cronológica, maturação esquelética, tamanho e composição corporal nas variações interindividuais do desempenho em sprints repetidos em adolescentes jogadores de futebol. Participaram do presente estudo 35 jogadores de futebol (idade: 14,9 ± 0,6 anos) de um clube de futebol profissional da Série A do campeonato brasileiro. As avaliações antropométricas e determinação da idade esquelética (método Fels) foram realizadas inicialmente em todos os jogadores (semana 1). As avaliações antropométricas incluíram as medidas de massa corporal, estatura e dobras cutâneas (tricipital e subescapular). As dobras cutâneas foram somadas para fornecer um índice de adiposidade subcutânea. Os participantes realizaram o teste de Carminatti (T-CAR) para a avaliação da capacidade de endurance intermitente (representada pelo pico de velocidade no T-CAR [PVT-CAR]) e um protocolo (6 x 20+20 m) para avaliar a capacidade de sprints repetidos (RSA:  melhor tempo [MTRSA] e tempo médio [TMRSA]) (semana 2). Correlações de Pearson e análises de regressão múltipla foram utilizadas para verificar a relação das variáveis independentes com o desempenho em sprints repetidos. Foi adotado o nível de significância de 5%. A idade cronológica, a idade esquelética e o PVT-CAR foram positivamente correlacionados com o MTRSA (r=0,42, 0,46 e 0,38; p<0,05) e TMRSA (r=0,53, 0,45 e 0,52; p<0,05), respectivamente. Além disso, a massa corporal e a adiposidade foram preditoras negativas do desempenho em sprints repetidos. As variáveis independentes explicaram 39% e 49% da variação interindividual do MTRSA e TMRSA, respectivamente. Em conclusão, a maturação esquelética, tamanho corporal, adiposidade, idade cronológica e a capacidade de endurance intermitente apresentaram associação de forma independente com a capacidade de sprints repetidos em jovens futebolistas.
Saúde mental, nível de atividade física e composição corporal se associam de forma diferente entre homens e mulheres?
Authors: Araújo Daniela Borges , Sanseverino Marcela Alves , Rodrigues Rodrigo
Published: January 2025

The Coronavirus Disease 2019 (COVID-19) started in 2019 and became a pandemic in 2020. Therefore, considerable changes have occurred in the routines of individuals due to social isolation. During this period, there was a reduction in physical activities and negative changes in body composition, factors that increase the risk of developing severe cases of COVID-19. Moreover, changes in mood state have been observed in men and women, which may be related to reported lifestyle habits. The aim of the study was to compare the mood state between men and women during the COVID-19 pandemic, investigating whether physical activity parameters and body composition are related to the mood state of men and women. Adults living in a city in the south of Brazil completed an electronic questionnaire, available on social networks and by e-mail, with questions about body mass and height (to calculate BMI), level of physical activity (IPAQ), change in body mass (by self-report) and mood (Brunel's Mood Scale). Associations were performed using multiple linear regression (Stepwise model). One hundred and fourteen responses were considered valid (66 - W; 48 – M). With the exception of anger, we observed that women had higher scores for negative mood states. Mood status was predicted in women by greater weight gain, high BMI, lower levels of physical activity, and having had COVID-19. Women seem to have a more negatively impacted mood state than men, and these parameters were predicted by lower levels of physical activity, increased body mass, higher BMI and having been contaminated by COVID-19.
Efeito da idade relativa no desempenho de nadadores em competições brasileiras nacionais
Authors: Medeiros Fabíola Bertú , Palhares Thiago dos Santos , Miyasato Lucas Felipe , Taurinho Natália Scalabrini , Araújo Sílvia Ribeiro Santos
Published: January 2025

The aim of this study was to compare the performance of athletes born in different quartiles in swimming competitions organized by the Brazilian Confederation of Aquatic Sports (CBDA), as well as to verify possible differences in the frequency of athletes born in these quartiles. The sample consisted of 7561 swimmers’ birth dates, who were in the top eighth positions in competitions organized by the CBDA in the 2017-2020 quadrennium. Athletes were grouped by their birth quartile, by their competitive category in the CBDA in the year of the competition and by sex. In addition, their position in the competition was quantified in points (10 to 3 points), ten points for the 1st place, nine points for the 2nd place, and so on. Chi-square and Friedman tests, with post-hoc Dwass-Steel-Critchlow-Fligner, were used to compare birth frequency and performance in different quartiles, respectively, with significance of 5%. Differences were identified in the athletes' birth distribution, in the sample without gender separation and considering this grouping variable, in practically all categories and in the sample as a whole. Regarding performance, the difference between individuals born in different quartiles was more prevalent in the sample without gender consideration and for male athletes. With the results of the present study, it is possible to conclude that RAE, both in frequency and in performance, exist in almost all analyzed categories and that for men it is more frequent in Brazilian competitors.
Diagnóstico geofísico por tomografia elétrica em subsídio à implantação de aterro sanitário
Authors: Nishimura Isabella Nantes , Fachin Sérgio Junior da Silva
Published: January 2025

A destinação adequada de resíduos sólidos domiciliares urbanos é discutida amplamente no Brasil e no mundo, porém é notável uma grande dificuldade para a sua aplicação, principalmente em cidades de pequeno porte do país. Neste contexto, este trabalho teve como finalidade utilizar o método geofísico da Eletrorresistividade como ferramenta para caracterização geológica de uma área destinada à implantação de aterro de resíduos, no município de Jaciara, estado de Mato Grosso. Os resultados obtidos por meio da técnica da Tomografia Elétrica permitiram observar as variações dos valores de resistividade ao longo das seções 2D e suas relações com valores naturais e anômalos. Os valores de resistividade menores que 100 Ω.m indicam a presença de zonas permeáveis (úmidas), já os valores acima de 537 Ω.m apontam para regiões mais resistivas, com solos arenosos insaturados e a presença do nível d’água varia entre 5 e 30 m de profundidade. A análise da variação de resistividade ao longo das seções, os parâmetros geológicos definidos pelas normas brasileiras e os ensaios direitos realizados na área, permitiram classificá-la como favorável para instalação do aterro de resíduos. O método demonstrou eficácia quando aplicado a problemas de engenharia, sendo utilizado para definição lito-estratigráfica e variações no teor de umidade, principalmente em áreas extensas, com redução do custo da aplicação de métodos diretos, sobretudo em municípios com recursos escassos.
Ecos do Casmurro em Budapeste, de Chico Buarque
Authors: Mello Jefferson Agostini , Machado Lohanna
Published: January 2025

A obra de Machado de Assis aparece em diversos momentos da ficção de Chico Buarque, tornando-se referência, também, quando o tema é a própria literatura, como seria o caso de Budapeste. Nesse romance, apresentam-se um narrador não-confiável e desconfiado, vaidoso e competitivo, mas ao mesmo tempo inseguro. A discussão dos seus percalços e sucessos na vida literária e sua busca por posição respeitável junto a seu público, em um relato de vingança, remetem à narrativa autobiográfica de Dom Casmurro.
Estereótipos e fetichização das personagens nipo-brasileiras em telenovelas nacionais
Authors: Kirihara Nayara Mika Kussaba , Zanella Cristine Koehler
Published: January 2025

Este artigo explora a representação das mulheres nipo-brasileiras em novelas televisivas brasileiras e conceitualiza os termos estereótipo, fetiche e representação. A partir da análise das tramas de Bang Bang (2005), Morde e Assopra (2011), Sol Nascente (2016), Malhação Viva a Diferença (2017) e contextualização da recepção do público e as controvérsias, o artigo examina como essas representações influenciam a percepção dos japoneses e seus descendentes, especialmente as mulheres retratadas no Brasil. O artigo inclui uma tabela que resume os principais pontos, uma análise dos dados e uma reflexão sobre a representação das mulheres nipo-brasileiras nas telenovelas e suas implicações para o debate sobre a representação midiática e seu impacto nas comunidades minoritárias.
O poeta é um forjador: três momentos hefésticos na lírica drummondiana
Authors: Aguiar Leonardo Ferreira
Published: January 2025

The present work stems from a play on words with a poem by Fernando Pessoa and a reference to the Greek mythology god Hephaestus, aiming to underscore the deliberate nature of composition in terms of form and content in three instances of Carlos Drummond de Andrade's lyrical works: “Poesia” from Alguma poesia, “Procura da poesia” from A rosa do povo, and “Oficina irritada” from Claro enigma. The comparison of these three poems aims to highlight how, over a span of twenty years, the poetry of the Itabira-born poet crafted new forms to engage with content influenced by the historical and social context surrounding his poetic endeavors. It recognizes that, despite challenges in extracting poetry from its realm of words and its transitive limitations in a fragmented world, art remains a viable means to interpret life.
Pele negra, máquinas do tempo: leituras sobre legado escravista e utopias através da viagem no tempo em Kindred e Dawn de Octavia Butler
Authors: Oliveira Leticia de
Published: January 2025

While studying the bibliography of the course Afropessimism, Afrofuturism and critical theories of race, taught by Prof. Dr. Marcos Piason Natali, it was possible to identify the multiple sufferings experienced by the black masses in the world in the form of literature, music, poetry and essays. Sometimes, these sufferings are projected into images of another life, imaginary worlds where dreams entangled with nightmares constitute another sociability, marked by complex desires and evil legacies. In the following pages, I investigate what I assume to be Octavia Butler's aesthetic subversion of the types of time travel in the novels Kindred (1979) and Dawn (1987). Firstly, we will discuss what meanings can be extracted from the comparison between the forms of time travel, the types of displacement (present → past / present → future) and the forms of the machines - when they exist - that make travelling possible. How do Afropessimism and Afrofuturism intersect with the way these journeys take place? Is there a theoretical debate related to the legacies of slavery, as well as strategies for overcoming these legacies, that it is possible to detach from these novels?
O sobrenatural na ficção
Authors: Woolf Virginia , Faria Carla Lento
Published: January 2025

Trata-se de uma tradução da resenha “The Supernatural in Fiction” (1958) de Virginia Woolf a respeito do livro The Supernatural in Modern Fiction (1917), de Dorothy Scarborough. Juntamente com “Gothic Romance” (1921) e “Henry James’ Ghost Stories” (1921), os texto faz parte dos breves momentos de sua obra em que desenvolveu a questão do sobrenatural, mais especificamente as histórias de fantasmas. Nesse sentido, em “The Supernatural in Fiction”, ao mesmo tempo em que comenta aspectos gerais do livro de Scarborough, Woolf também reflete acerca do status da ficção sobrenatural no século XX.
O sinistro deslizar dos anos: tempo e transitoriedade na ficção curta de Carson McCullers
Authors: Gonçalves Giovana Proença
Published: January 2025

This essay proposes an analysis of "The Sojourner," a short story penned by American author Carson McCullers, with a specific focus on the themes of time and transience within the narrative. Through close reading, our aim is to explore how these themes not only surface in the theme but also intricately shape the structure, ultimately portraying the improvisation of human existence. Delving into both the content and stylistic elements of the story, we aim to construct an interpretation that delves into the realms of memory, personal temporality, crises of inner life; and the pervasive sense of isolation—a theme which McCullers underscored as central to her fiction. Furthermore, we endeavor to draw connections between the societal backdrop of mid-20th century United States and the temporal experiences depicted within the story, particularly through the lens of disintegration as perceived by the protagonist, John Ferris.Our theoretical framework draws upon insights from esteemed critics including Walter Benjamin, Fredric Jameson, and the Brazilian critic Benedito Nunes, borrowing notably from Nunes' concept of "psychological time." Additionally, we integrate perspectives gleaned from critiques of McCullers' oeuvre as well as reflections from the author herself, shedding light on the underlying American ethos. Ultimately, our aim is to underscore how "The Sojourner" serves as a poignant exploration of humanity's struggle to navigate the relentless flow of time, its inevitable failures in attempting to assert control, and the enduring omnipresence of temporal forces.
Safety of Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy: The ALLY Pilot Trial
Authors: Zaidi Syed F. , Castonguay Alicia C. , Zaidat Osama O. , Jadhav Ashutosh P. , Sheth Sunil A. , Haussen Diogo C. , Nguyen Thanh N. , Burgess Richard E. , Alhajala Hisham S. , Gharaibeh Khaled , Salahuddin Hisham , Rao Rahul , Oliver Marion J. , Jumaa Mouhammad A.
Published: January 2025

BACKGROUND:

Recent studies suggest that the use of adjunctive intraarterial alteplase after mechanical thrombectomy (MT) may improve outcomes; however, there are limited data on the use of intraarterial tenecteplase, a newer-generation lytic, in this acute ischemic stroke patient population. Here, we evaluate the use of intraarterial tenecteplase in the ALLY pilot study (Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy).

METHODS:

ALLY was a prospective, single-center, nonrandomized pilot study assessing the feasibility and safety of intraarterial tenecteplase up to 4.5 mg in acute ischemic stroke-large vessel occlusion MT patients with incomplete recanalization. The primary safety end point was any intracranial hemorrhage and neurological worsening by ≥4 points on the National Institutes of Health Stroke Scale within 24 hours of treatment with intraarterial tenecteplase. A post hoc analysis was performed with a control cohort of MT patients (ALLY MT) not receiving intraarterial tenecteplase.

RESULTS:

From April 2022 to July 2023, 218 MTs were performed at ProMedica Hospital (Toledo, OH), of which 20 patients were enrolled in ALLY. The mean age was 66.1±13.8 years, with 35% women. Median baseline National Institutes of Health Stroke Scale scores and Alberta Stroke Program Early CT Scores were 13 (interquartile range, 9–18.8) and 10 (interquartile range, 9–10), respectively. IV thrombolysis was administered in 55%. Most patients presented with middle cerebral artery occlusion (90%). Post-MT modified Treatment in Cerebral Ischemia grade was 2b and 2c in 11 and 9 patients, respectively. Final modified Treatment in Cerebral Ischemia 2b, 2c, and 3 was achieved in 55% (11/20), 35% (7/20), and 10% (2/20), respectively. Any intracranial hemorrhage was observed in 11 patients; however, only 1 patient had symptomatic intracranial hemorrhage. A favorable functional outcome (modified Rankin Scale score, 0–2) at 90 days was achieved in 50%. No difference in intracranial hemorrhage rates was observed between the ALLY and ALLY MT cohorts.

CONCLUSIONS:

The use of adjunctive intraarterial tenecteplase up to 4.5 mg in patients with acute ischemic stroke with incomplete reperfusion post-MT is feasible and was not associated with increased rates of hemorrhage. Larger, randomized studies are needed to assess the safety and efficacy of intraarterial tenecteplase in this population.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT05172934.
Neural signatures of online and offline motor learning: An ALE meta-analysis
Authors: Byczynski Gabriel , Arulchelvan Elva , Grootjans Yvette , Scarlat Iulia-Mara , Brady Simone , Kamdar Sophie , Vanneste Sven
Published: January 2025

Neural activation patterns underlying motor learning that are captured using functional imaging can only reflect the patterns occurring at a given moment. Motor learning is known to comprise many processes which are variably biologically or temporally distinct. In order to improve the understanding of how regional activation patterns may vary across different mechanisms of motor learning, we performed an ALE meta-analysis of imaging studies that directly compares online and offline motor learning. Using coordinate-based meta-analysis methods and independent review, 1777 studies were returned from 3 databases. Thirty-eight studies investigating motor task learning met the inclusion criteria, were allocated as either online or offline learning based on their scanning placement, and revealed both unique and overlapping regional activation/deactivation patterns. We identify activation changes in regions that are consistent for online learning and offline learning. Our findings concur with those of previous meta-analyses investigating online motor learning, and find support for previous theories surrounding the networks involved in consolidation and offline processes in motor learning. Shared activation between online and offline motor learning was found in the supplemental motor area and somatosensory cortex, highlighting regions which are continually involved in both processes, and identifying those which may be differentially modulated to alter motor learning outcomes.
Hierarchical surprise signals in naturalistic violation of expectations
Authors: Plikat Vincent , Grassi Pablo R. , Frack Julius , Bartels Andreas
Published: January 2025

Surprise responses signal both high-level cognitive alerts that information is missing, and increasingly specific back-propagating error signals that allow updates in processing nodes. Studying surprise is, hence, central for cognitive neuroscience to understand internal world representations and learning. Yet, only few prior studies used naturalistic stimuli targeting our high-level understanding of the world. Here, we use magic tricks in an fMRI experiment to investigate neural responses to violations of core assumptions held by humans about the world. We showed participants naturalistic videos of three types of magic tricks, involving objects appearing, changing color, or disappearing, along with control videos without any violation of expectation. Importantly, the same videos were presented with and without prior knowledge about the tricks’ explanation. Results revealed generic responses in frontal and parietal areas, together with responses specific to each of the three trick types in posterior sensory areas. A subset of these regions, the midline areas of the default mode network (DMN), showed surprise activity that depended on prior knowledge. Equally, sensory regions showed sensitivity to prior knowledge, reflected in differing decoding accuracies. These results suggest a hierarchy of surprise signals involving generic processing of violation of expectations in frontal and parietal areas with concurrent surprise signals in sensory regions that are specific to the processed features.
Characteristics of gouging by captive-born silvery marmosets in gum-producing trees
Authors: Le Fondré Jamie , Price Eluned C. , Arnold Charlotte , Wormell Dominic
Published: January 2025

Marmosets are obligate gummivores with evolutionary adaptations to harvesting tree exudates. We studied a group of zoo-living free-ranging silvery marmosets (Mico argentatus) that had learned to feed from Prunus spp., to investigate the characteristics of the holes they gouged in four Portuguese laurel trees (Prunus lusitanica). Holes were frequently extended in more than one direction from the base, often producing roughly V-shaped channels. The angles of the holes from the vertical were significantly different from a random distribution and averaged 40° ± 2.1 SE. Mean hole length was 50.9 mm ± 3.4 SE. Mean depth of gouge holes was 5.08 mm ± 0.17 SE and was consistent along the length of the holes. Feeding on Prunus was concentrated in the late morning, and constituted 26.2% of records of the marmosets’ overall activity during group scans. Further studies are needed to investigate whether there are consistent species or generic differences in the methods used to harvest gum by marmosets, and whether marmosets use different gouging techniques for different plant species. Understanding how marmosets identify and use new gum sources will be important for their conservation in habitats altered by anthropogenic impacts.
Précis of Why We Doubt
Authors: Pinillos Ángel
Published: January 2025

I selectively summarize some of the main ideas in my book Why We Doubt, focusing on the elements that are discussed in the replies from commentators. In the book, I investigated our skeptical intuitions which form the basis of the skeptic’s arguments. I argue that these intuitive judgments or inclinations to judge are produced by the deployment of a subconscious heuristic, pbs, which serves us well most of the time but misfires in esoteric cases like those associated with global skepticism. I do this by identifying the rational function of pbs and arguing that when we apply this rational function to global skepticism, it doesn’t yield a skeptical result.
Replies to Commentators
Authors: Pinillos Ángel
Published: January 2025

I respond to comments from Branden Fitelson, Chad Gonnerman and John Waterman, and Mark Walker. My response to Fitelson concerns how we should understand the notion of “sensitivity” which is central to my account of why we find skeptical premises intuitive. I argue against his recommendation except for a specific type of “loose” skeptical hypothesis. Gonnerman and Waterman push me to say more about the conditions under which we feel or not feel the skeptical pull. I clarify and expand on the theory presented in the book. Finally, Walker presents a new type of skeptical challenge. To deal with this challenge, I distinguish between two types of skeptical hypotheses, a mild and more substantial one. Walker’s skeptical argument concerns mild skepticism. My account is aimed at more substantial accounts. However, I speculate about how we may respond to this challenge.
Brewery waste as a sustainable protein source for the banded cricket (Gryllodes sigillatus)
Authors: Kasdorf S.Y. , Muzzatti M.J. , Haider F. , Bertram S.M. , MacMillan H.A.
Published: January 2025

Crickets, like other edible insects, can convert organic by-products of the food and agricultural industries into high-value protein. Waste products high in protein like brewer’s spent grain and brewer’s spent yeast are particularly attractive replacements for unsustainable protein sources in cricket feed like fishmeal or soy. Such replacement will only be advantageous, however, if feeding on these waste products does not impact, or only minimally impacts, cricket survival, growth, and body composition. In this study, a farmed cricket species, Gryllodes sigillatus, was reared in isolation on experimental diets in which fishmeal was wholly or partially replaced with either brewer’s spent grain or brewer’s spent yeast. Cricket survival, development and macromolecular composition were not different across diets. However, wholly replacing fishmeal with brewer’s spent yeast or brewer’s spent grain reduced cricket adult body mass by approximately 16%. To extend these findings toward a farm environment, a second cohort of crickets were reared communally on diets in which fishmeal, and fishmeal and soy (a secondary protein source), were replaced by brewer’s spent grain. We found that in a communal environment, crickets reared on both diets performed equally as well as the control. Therefore, brewing waste products are promising candidates for use as a primary protein source in the feed of G. sigillatus. In addition to contributing towards the goals of a circular bioeconomy through the repurposing of waste, the use of brewing waste in cricket feed may have a positive impact of the cricket farming industry as a cost-effective and sustainable alternative to traditional feed.
On the taxonomy of the genus Miltochrista Hübner with descriptions of six new species from the Oriental Realm (Lepidoptera: Erebidae: Arctiinae: Lithosiini)
Authors: VOLYNKIN ANTON V. , SINGH SANTOSH , ČERNÝ KAREL , KIRTI JAGBIR SINGH , DATTA HARVINDER SINGH , SINGH NAVNEET
Published: January 2025

The present paper is devoted to the taxonomy of the genus Miltochrista Hübner, [1819] with a special emphasis to the Indian fauna. Six new species of the genus are described: M. gopaldhara Volynkin, Černý, N. Singh, Kirti, Datta & S. Singh, sp. nov. (Northeast India), M. mawphlang N. Singh, Kirti, Datta, S. Singh, Volynkin & Černý, sp. nov. (Northeast India), M. carcharias Volynkin, Černý, N. Singh, Kirti, Datta & S. Singh, sp. nov. (Northeast and South India), M. ephimeces Volynkin, Černý, N. Singh, Kirti, Datta & S. Singh, sp. nov. (Northeast India and northern Myanmar), M. jatinga N. Singh, Volynkin, Černý, Kirti, Datta & S. Singh, sp. nov. (Northeast India, northern Myanmar and Northern Thailand), and M. nuranang N. Singh, Volynkin, Černý, Kirti, Datta & S. Singh, sp. nov. (Northeast India and Nepal). One taxon is reassessed to species level: Miltochrista butleri Leech, [1889], stat. rev. Two new synonyms are introduced: M. neoseriata N. Singh & Kirti, 2016 = M. pseudoseriata N. Singh & Kirti, 2016, syn. nov., and M. floccosa (Walker, [1865]) = Asura violacea Reich, 1936, syn. nov. One synonym is revised: M. floccosa (Walker, [1865]) = Nudaria subcervina Walker, [1865], syn. rev. A neotype is designated for Nudaria subcervina Walker, [1865]. Lectotypes are designated for Asura lacteoflava lacteoflava Rothschild, 1913, Asura lacteoflava aureata Rothschild, 1913, Setina dharma Moore, 1879, Miltochrista butleri Leech, [1889], Lyclene discistriga Moore, 1878, and Sesapa andamana Moore, 1877. The male genitalia of M. paraseriata N. Singh & Kirti, 2016 are correctly illustrated and diagnosed for the first time. Polymorphism of M. dharma is illustrated and discussed. Six species are reported for the first time from the following countries: M. dharma (Moore, 1879) and M. floccosa (Walker, [1865]) from Pakistan and Nepal; M. terminata (Moore, 1878) from Myanmar and Thailand; M. vidlickai Bucsek, 2020 from Vietnam and Thailand; M. quadrata (Holloway, 2001) from Indonesia (Sumatra), Thailand and India (Assam); and M. producta (Černý, 2009) from Nepal and Vietnam. Adults as well as male and female genitalia are illustrated.
Cherax pulverulentus, a new freshwater crayfish (Decapoda: Parastacidae) from Southwest Papua Province, Indonesia
Authors: PATOKA JIŘÍ , AKMAL SURYA GENTHA , BLÁHA MARTIN , KOUBA ANTONÍN
Published: January 2025

Cherax pulverulentus sp. nov. is a moderately-sized burrowing freshwater crayfish endemic to the streams west of the Ayamaru Lake in Bird's Head Peninsula (Framu Subdistrict, Southwest Papua Province), the Indonesian part of New Guinea. Although this species has been exploited in the ornamental aquarium trade at least for 21 years, it has not been formally named until now. Its commonly used commercial names in the pet trade are: “Hoa Creek”, “Irian Jaya”, or “Blue Moon” crayfish, but these names are also used for other more bluish or pinkish species of Cherax. Cherax pulverulentus sp. nov. is genetically and morphologically most similar to Cherax pulcher Lukhaup, 2015, but both species may be distinguished by several morphological characteristics and DNA sequence divergence, which support C. pulverulentus sp. nov. as a valid species.
Descriptions of two new species of the leafhopper genus Idioscopus Baker (Hemiptera: Cicadellidae: Eurymelinae: Idiocerini) from China
Authors: GUO MEISHU , DAI RENHUAI
Published: January 2025

Two new species of the leafhopper genus Idioscopus Baker, I. triprocessus sp. nov. and I. xanthomacula sp. nov., are described and illustrated from China. I. myrica Wang & Dai, 2018 is placed as a junior synonym of I. bimaculatus (Pruthi, 1936) syn. nov. A checklist and key to species of Idioscopus Baker from China are provided.
How exposure to natives in the workplace affects cultural assimilation among non-Western immigrants
Authors: Diop Lanciné Eric Nestor , Diop-Christensen Anna , Hedegaard Troels Fage
Published: January 2025

Employment plays a significant role in the assimilation of immigrants, forming a central assumption of contemporary work-first policies aimed at integrating immigrant populations. This assumption is supported by existing research, which posits that workplace interactions with natives foster immigrants’ cultural assimilation into the mainstream. In this article, we argue that while employment generally facilitates assimilation, it may not be sufficient on its own. Specifically, the potential for assimilation is limited if immigrants are not exposed to natives in the workplace. To examine this, we analysed survey data from non-Western immigrants in Denmark, in combination with Danish register data to quantify their degree of workplace exposure to natives. Our findings reveal that a share of the positive relationship between employment and assimilation observed in previous studies hinges on such workplace exposure. Additionally, we show that experiences of discrimination can undermine the positive effects of intergroup workplace interactions on cultural assimilation. These results highlight the need for assimilation policies that go beyond merely encouraging employment. Therefore, policies aimed at assimilation must ensure that immigrants have exposure to natives and are protected from discrimination to maximise the assimilatory potential of employment.
Likelihood of Whole-Grade or Subject Acceleration for Twice-Exceptional Students
Authors: LeBeau Brandon , Assouline Susan G. , Foley-Nicpon Megan , Lupkowski-Shoplik Ann , Schabilion Katherine
Published: January 2025

Academic acceleration, which enhances challenges for academically gifted students, can be subject-based or whole-grade. Limited research has explored its application in the twice-exceptional population, where students possess notable cognitive strengths and challenges due to psychological diagnoses. Our clinical study investigates the likelihood of subject or whole-grade acceleration, considering IQ, age, and achievement differences across diagnosis types and demographics. The clinical sample of 1,189 subjects was used to explore the research questions. Subject-based acceleration is more likely for students with diagnoses of depression or anxiety, gifted program participation, or medium socioeconomic status. Males with specific learning disabilities (SLDs) are less likely to be subject-based accelerated. Whole-grade acceleration was likelier for students diagnosed with anxiety. At the same time, those with medium or low socioeconomic status, and ADHD, ASD, or SLD diagnoses, were less likely to be whole-grade accelerated.
Teachers’ Views of Academically Gifted Students Through the Lens of the COVID-19 Pandemic: A Qualitative Study in Three Countries
Authors: Altaras Ana , Šimon Jana , Jolić Marjanović Zorana , Podlesek Anja
Published: January 2025

This cross-country study employed a qualitative design to explore teachers’ views of their gifted students and of these students’ adjustment and education during the Covid-19 pandemic. A total of 52 teachers from Croatia, Serbia, and Slovenia were interviewed about gifted students in general and, in continuation, about a particular gifted student who was selected for the purpose of this study. In both instances and across all three countries, the teachers tended to describe gifted students mainly in terms of the “harmony hypothesis.” Teaching these students in pandemic circumstances only added to the harmony view: The gifted were seen as having adapted quickly and without much academic loss to the new (learning) conditions. Nevertheless, the pandemic experience also seems to have allowed teachers to see a systemic neglect of gifted students and clearly notice the need for proper enrichment and social-emotional support if these students are to reach their full potential.
A Crisis of Legitimacy? Human Rights, Diplomacy, and the Red Army Faction, 1970–80
Authors: Corke Catriona
Published: January 2025

When the West German authorities responded to the threat posed by the Red Army Faction during the 1970s, they also faced criticism from increasingly internationalized civil society initiatives in defence of human rights. West German activist intellectuals sought to publicize inhumane prison conditions like solitary confinement, as well as wider-reaching measures like the 1972 Anti-Radical Decree which excluded those deemed to hold ‘anti-constitutional views’ from the civil service. Although dismissed by their domestic political opponents as pro-terrorist posturing, the rising currency of human rights in this decade made criticism of prison conditions a more potent issue on an international scale. Criticism of West German conditions in terms of ‘human rights’ was, however, a double-edged sword. It afforded domestic issues considerable international resonance. But it also sparked an official response that focused more on repairing West Germany's international image through counterpublicity campaigns than on investigating the veracity – or otherwise – of the Left's criticism of domestic conditions. Government officials saw the language of human rights as too important to hand over to left-wing opponents. To them, it was an opportunity for the Federal Republic to signal its rehabilitation as a liberal democracy and criticism of domestic conditions threatened to undermine this project.
“It Was So Easy in a Situation That’s So Hard”: Structural Stigma and Telehealth Abortion
Authors: Becker Andréa , Doria Celina , Koenig Leah R. , Ko Jennifer , Upadhyay Ushma
Published: January 2025

For decades, sociological research has examined the role of stigma in contributing to health disparities, yet such research seldom grapples with the interplay between individuals and structures. There is a particular paucity of research on abortion that concurrently examines individual experiences with stigma and structural barriers. In this article, we use telehealth abortion as a case, which now accounts for one in five abortions in the United States. We conducted 30 interviews and approach the data using a structural stigma framework in tandem with conceptualizations of felt, internalized, and enacted stigma. Findings advance a sociological theory of structural abortion stigma: a combination of structural barriers, internalized beliefs, and interpersonal shame. Telehealth reduces structural barriers to abortion and mitigates internal and interpersonal experiences of stigma. The latter is achieved by the ability to avoid the traditional abortion clinic, which many interviewees view as the site where stigma is produced and experienced.
The Fear Primacy Hypothesis in the Structure of Emotional States: A Systematic Literature Review
Authors: Efremov Andrei
Published: January 2025

Fear, an emotion ingrained through evolutionary adaptation, triggers protective responses to ward off threats. Yet, in some instances, the neural networks tied to fear can lead to psychosomatic ailments and behavioural issues, including the maladaptive type. This study aims to hypothesize about fear, probing its neurophysiological traits and its impact on cognitive-emotional facets of the psyche. A systematic review of theoretical literature was conducted, utilizing PubMed and Scopus databases. Comparative analysis, abstraction, and synthesis methods were employed, and 34 sources that met the inclusion criteria analysed. Our findings highlight the pivotal role fear plays in the human psyche, potentially serving as the foundation for all emotions, feelings, and states experienced by individuals. Treating fear and related anxiety disorders poses challenges due to the recurrence of fear-based memories, which perpetuate negative symptoms in patients. Various techniques, like hypnotherapy, cognitive behavioural therapy, and exposure therapy, are actively employed with these patients. However, none offer a universal solution, necessitating personalized approaches to address individual fears. MindChat may be promising in therapeutic settings to address fear responses without altering cognition or fostering avoidance behaviour, but empirical evidence supporting its efficacy is limited, and further research is needed to validate its effectiveness. The utilization of fear as a potent tool in engaging with the psyche underscores the potential value of this study for psychotherapists in clinical practice and professionals in affective neurobiology and behavioural psychology. It redirects attention toward fear’s significance, urging a deeper exploration in future research endeavours.