bluuebunny/crossref_metadata_2025 huggingface dataset:
Benefit of linking hospital resource information and patient-level stroke registry data
Authors: Purvis Tara , Cadilhac Dominique A , Hill Kelvin , Gibbs Adele K , Ghuliani Jot , Middleton Sandy , Kilkenny Monique F
Published: January 2023

Variation in the delivery of evidence-based care affects outcomes for patients with stroke. A range of hospital (organizational), patient, and clinical factors can affect care delivery. Clinical registries are widely used to monitor stroke care and guide quality improvement efforts within hospitals. However, hospital features are rarely collected. We aimed to explore the influence of hospital resources for stroke, in metropolitan and regional/rural hospitals, on the provision of evidence-based patient care and outcomes. The 2017 National Audit organizational survey (Australia) was linked to patient-level data from the Australian Stroke Clinical Registry (2016–2017 admissions). Regression models were used to assess the associations between hospital resources (based on the 2015 Australian National Acute Stroke Services Framework) and patient care (reflective of national guideline recommendations), as well as 90–180-day readmissions and health-related quality of life. Models were adjusted for patient factors, including the severity of stroke. Fifty-two out of 127 hospitals with organizational survey data were merged with 22 832 Australian Stroke Clinical Registry patients with an admission for a first-ever stroke or transient ischaemic attack (median age 75 years, 55% male, and 66% ischaemic). In metropolitan hospitals (n = 42, 20 977 patients, 1701 thrombolyzed, and 2395 readmitted between 90 and 180 days post stroke), a faster median door-to-needle time for thrombolysis was associated with ≥500 annual stroke admissions [−15.9 minutes, 95% confidence interval (CI) −27.2, −4.7], annual thrombolysis >20 patients (−20.2 minutes, 95% CI −32.0, −8.3), and having specialist stroke staff (dedicated medical lead and stroke coordinator; −12.7 minutes, 95% CI −25.0, −0.4). A reduced likelihood of all-cause readmissions between 90 and 180 days was evident in metropolitan hospitals using care pathways for stroke management (odds ratio 0.82, 95% CI 0.67–0.99). In regional/rural hospitals (n = 10, 1855 patients), being discharged with a care plan was also associated with the use of stroke clinical pathways (odds ratio 3.58, 95% CI 1.45–8.82). No specific hospital resources influenced 90–180-day health-related quality of life. Relevant to all international registries, integrating information about hospital resources with clinical registry data provides greater insights into factors that influence evidence-based care.
Prevalence and genetic characteristics offosB-positiveStaphylococcus aureusin duck farms in Guangdong, China in 2020
Authors: Hu Jianxin , Chen Lin , Li Guihua , Pan Yu , Lu Yixing , Chen Jin , Xiong Wenguang , Zeng Zhenling
Published: January 2023

Objectives

To investigate the epidemiology of fosB-positive Staphylococcus aureus in waterfowl farms in the Pearl River tributaries in Guangdong Province, China in 2020.

Methods

A total of 63 S. aureus were recovered from 315 samples collected from six duck farms and one goose farm. PFGE, WGS and analysis were performed on 19 fosB-positive S. aureus.

Results

The fosfomycin resistance rate of the strains was as high as 52.4% (33/63), and 30.1% (19/63) of the strains carried fosB. Resistance gene prediction results showed that duck farm environment-derived strains contained the oxazolidinone drug resistance gene optrA. All fosB-positive S. aureus were MRSA and most of them were MDR, mainly ST9-t899 and ST164-t899. PFGE showed that fosB-positive S. aureus from humans and ducks could be clustered into the same clade. In addition, core-genome SNP analysis showed that clonal transmission of S. aureus occurred between humans and water. Pan-genome analysis showed that S. aureus had an open pangenome. The fosB gene was located on 2610–2615 bp plasmids, which all contained a broad host-range plasmid replication protein family 13. Small plasmids carrying the fosB gene could be found in different multilocus STs of S. aureus.

Conclusions

This study indicated that duck farms in Guangdong, China could be an important reservoir of fosB-positive S. aureus. The spread of drug-resistant bacteria in waterfowl farms requires further monitoring.
Reporting Peers’ Wrongdoing: Evidence on the Effect of Incentives on Morally Controversial Behavior
Authors: Fiorin Stefano
Published: January 2023

I show that offering monetary rewards to whistleblowers can backfire as a moral aversion to being paid for harming others can reverse the effect of financial incentives. I run a field experiment with employees of the Afghan Ministry of Education, who are asked to confidentially report on their colleagues’ attendance. I use a two-by-two design, randomizing whether or not reporting absence carries a monetary incentive as well as the perceived consequentiality of the reports. In the consequential treatment arm, where employees are given examples of the penalties that might be imposed on absentees, 15% of participants choose to denounce their peers when reports are not incentivized. In this consequential group, rewards backfire: Only 10% of employees report when denunciations are incentivized. In the non-consequential group, where participants are guaranteed that their reports will not be forwarded to the government, only 6% of employees denounce absence without rewards. However, when moral concerns of harming others are limited through the guarantee of non-consequentiality, rewards do not backfire: The incentivized reporting rate is 12%.
The accretion history of the Milky Way – I. How it shapes globular clusters and dwarf galaxies
Authors: Hammer Francois , Li Hefan , Mamon Gary A , Pawlowski Marcel S , Bonifacio Piercarlo , Jiao Yongjun , Wang Haifeng , Wang Jianling , Yang Yanbin
Published: January 2023

Halo inhabitants are individual stars, stellar streams, star, and globular clusters, and dwarf galaxies. Here we compare the two last categories that include objects of similar stellar mass, which are often studied as self-dynamical equilibrium systems. We discover that the half-light radius of globular clusters depends on their orbital pericentre and total energy, and that Milky Way (MW) tides may explain the observed correlation. We also suggest that the accretion epoch of stellar systems in the MW halo can be calibrated by the total orbital energy, and that such a relation is due to both the mass growth of the MW and dynamical friction affecting mostly satellites with numerous orbits. This calibration starts from the bulge to Kraken, Gaia Sausage Enceladus, Sagittarius stellar systems, and finally to the new coming dwarfs, either or not linked to the vast-polar structure. The most eccentric globular clusters, and dwarfs have their half-light radius scaling as the inverse of their binding energy, and this over more than two decades. This means that earlier arriving satellites are smaller due to the tidal effects of the MW. Therefore, most halo inhabitants appear to have their structural parameters shaped by MW tides, and also by ram-pressure for the most recent arrivals, the dwarf galaxies. The correlations found in this study can be used as tools to further investigate the origin of globular clusters and dwarfs, as well as the assembly history of our Galaxy.
Empirical constraints on the nucleosynthesis of nitrogen
Authors: Johnson James W , Weinberg David H , Vincenzo Fiorenzo , Bird Jonathan C , Griffith Emily J
Published: January 2023

We derive empirical constraints on the nucleosynthetic yields of nitrogen by incorporating N enrichment into our previously developed and empirically tuned multizone galactic chemical evolution model. We adopt a metallicity-independent (‘primary’) N yield from massive stars and a metallicity-dependent (‘secondary’) N yield from AGB stars. In our model, galactic radial zones do not evolve along the observed [N/O]–[O/H] relation, but first increase in [O/H] at roughly constant [N/O], then move upward in [N/O] via secondary N production. By t ≈ 5 Gyr, the model approaches an equilibrium [N/O]–[O/H] relation, which traces the radial oxygen gradient. Reproducing the [N/O]–[O/H] trend observed in extragalactic systems constrains the ratio of IMF-averaged N yields to the IMF-averaged O yield of core-collapse supernovae. We find good agreement if we adopt $y_\text{N}^\text{CC}/y_\text{O}^\text{CC}=0.024$ and $y_\text{N}^\text{AGB}/y_\text{O}^\text{CC} = 0.062(Z/Z_\odot)$. For the theoretical AGB yields we consider, simple stellar populations release half their N after only ∼250 Myr. Our model reproduces the [N/O]–[O/H] relation found for Milky Way stars in the APOGEE survey, and it reproduces (though imperfectly) the trends of stellar [N/O] with age and [O/Fe]. The metallicity-dependent yield plays the dominant role in shaping the gas-phase [N/O]–[O/H] relation, but the AGB time-delay is required to match the stellar age and [O/Fe] trends. If we add ∼40 per cent oscillations to the star formation rate, the model reproduces the scatter in the gas phase [N/O]–[O/H] relation observed in external galaxies by MaNGA. We discuss implications of our results for theoretical models of N production by massive stars and AGB stars.
The relationship between galaxy and halo sizes in the Illustris and IllustrisTNG simulations
Authors: Karmakar Tathagata , Genel Shy , Somerville Rachel S
Published: January 2023

Abundance matching studies have shown that the average relationship between galaxy radius and dark matter halo virial radius remains nearly constant over many orders of magnitude in halo mass, and over cosmic time since about z = 3. In this work, we investigate the predicted relationship between galaxy radius re and halo virial radius Rh in the numerical hydrodynamical simulations Illustris and IllustrisTNG from z ∼ 0–3, and compare with the results from the abundance matching studies. We find that Illustris predicts much higher re/Rh values than the constraints obtained by abundance matching, at all redshifts, as well as a stronger dependence on halo mass. In contrast, IllustrisTNG shows very good agreement with the abundance matching constraints. In addition, at high redshift it predicts a strong dependence of re/Rh on halo mass on mass scales below those that are probed by existing observations. We present the predicted re/Rh relations from Illustris and IllustrisTNG for galaxies divided into star forming and quiescent samples, and quantify the scatter in re/Rh for both simulations. Further, we investigate whether this scatter arises from the dispersion in halo spin parameter and find no significant correlation between re/Rh and halo spin. We investigate the paths in re/Rh traced by individual haloes over cosmic time, and find that most haloes oscillate around the median re/Rh relation over their formation history.
The resolved chemical composition of the starburst dwarf galaxy CGCG007-025: direct method versus photoionization model fitting
Authors: Fernández V , Amorín R , Sanchez-Janssen R , del Valle-Espinosa M G , Papaderos P
Published: January 2023

This work focuses on the gas chemical composition of CGCG007-025. This compact dwarf is undergoing a galaxy wide star-forming burst, whose spatial behaviour has been observed by VLT/MUSE. We present a new line measurement library to treat almost 7800 voxels. The direct method chemical analysis is limited to 484 voxels with good detection of the $[\mathrm{S}\, {\small III}]6312\, \mathring{\rm A}$ temperature diagnostic line. The recombination fluxes are corrected for stellar absorption via a population synthesis. Additionally, we discuss a new algorithm to fit photoionization models via neural networks. The eight ionic abundances analysed show a spatial normal distribution with a $\sigma \sim 0.1\, {\rm dex}$, where only half this value can be explained by the uncertainty in the measurements. The oxygen abundance distribution is 12 + log(O/H) = 7.88 ± 0.11. The ${\it T}_{e}[\mathrm{S}\, {\small III}]$ and ne[S ii] are also normally distributed. However, in the central and brightest region, the ne[S ii] is almost thrice the mean galaxy value. This is also reflected in the extinction measurements. The ionization parameter has a distribution of ${\rm log}(U) = -2.52^{0.17}_{0.19}$. The parameter spatial behaviour agrees with the S2+/S+ map. Finally, the discrepancies between the direct method and the photoionization model fitting are discussed. In the latter technique, we find that mixing lines with uneven uncertainty magnitudes can impact the accuracy of the results. In these fittings, we recommend overestimating the minimum flux uncertainty one order below the maximum line flux uncertainty. This provides a better match with the direct method.
Investigating the variability of Swift-BAT blazars with NICER
Authors: Mundo Sergio A , Mushotzky Richard
Published: January 2023

We present results of X-ray spectral and time-domain variability analyses of four faint, ‘quiescent’ blazars from the Swift-BAT 105-month catalogue. We use observations from a recent, 5-month long NICER campaign, as well as archival BAT data. Variations in the 0.3–2 keV flux are detected on minute, ∼weekly, and monthly time-scales, but we find that the fractional variability Fvar on these time-scales is <25 per cent and decreases on longer time-scales, implying generally low-amplitude variability across all sources and showing very low variability on monthly time-scales ($F_{\rm var}\lesssim 13{{\ \rm per\ cent}}$), which is at odds with previous studies that show that blazars are highly variable in the X-rays on a wide range of time-scales. Moreover, we find that the flux variability on very short time-scales appears to be characterized by long periods of relative quiescence accompanied by occasional short bursts, against the relatively time-stationary nature of the variability of most other AGN light curves. Our analysis also shows that the broadband X-ray spectra (0.3–195 keV) of our sources can be described with different power-law models. As is the case with most blazars, we find that two sources (2MASS J09343014-1721215 and PKS 0312-770) are well-modelled with a simple power law, while the remaining two (1RXS J225146.9-320614 and PKS 2126-15) exhibit curvature in the form of a log-parabolic power law. We also find that, in addition to the continuum, PKS 2126-15 requires significant absorption at the soft X-rays (≲1 keV) to fully describe the observed curvature, possibly due to absorption from the intergalactic medium.
Revised constraints on the photon mass from well-localized fast radio bursts
Authors: Lin Hai-Nan , Tang Li , Zou Rui
Published: January 2023

We constrain the photon mass from well-localized fast radio bursts (FRBs) using Bayes inference method. The probability distributions of dispersion measures (DMs) of host galaxy and intergalactic medium are properly taken into account. The photon mass is tightly constrained from 17 well-localized FRBs in the redshift range 0 < z < 0.66. Assuming that there is no redshift evolution of host DM, the 1σ and 2σ upper limits of photon mass are constrained to be mγ < 4.8 × 10−51 kg and mγ < 7.1 × 10−51 kg, respectively. Monte Carlo simulations show that even enlarging the FRB sample to 200 and extending the redshift range to 0 < z < 3 could not significantly improve the constraining ability on photon mass. This is because of the large uncertainty on the DM of intergalactic medium.
Enabling discovery of gravitationally lensed explosive transients: a new method to build an all-sky watch list of groups and clusters of galaxies
Authors: Ryczanowski Dan , Smith Graham P , Bianconi Matteo , McGee Sean , Robertson Andrew , Massey Richard , Jauzac Mathilde
Published: January 2023

Cross-referencing a watch list of galaxy groups and clusters with transient detections from real-time streams of wide-field survey data is a promising method for discovering gravitationally lensed explosive transients, including supernovae, kilonovae, gravitational waves, and gamma-ray bursts in the next 10 yr. However, currently there exists no catalogue of objects with both sufficient angular extent and depth to adequately perform such a search. In this study, we develop a cluster-finding method capable of creating an all-sky list of galaxy group- and cluster-scale objects out to z ≃ 1 based on their lens-plane properties and using only existing data from wide-field infrared surveys such as VISTA Hemisphere Survey and UKIRT Hemisphere Survey, and all-sky WISE (Wide-field Infrared Survey Explorer) data. In testing this method, we recover 91 per cent of a sample containing known and candidate lensing objects with Einstein radii of θE ≥ 5 arcsec. We also search the surrounding regions of this test sample for other groups and clusters using our method and verify the existence of any significant findings by visual inspection, deriving estimates of the false positive rate that are as low as 6 per cent. The method is also tested on simulated Rubin data from their Data Preview 0 programme, which yields complementary results of a good recovery rate of ≳80 per cent for M200 ≥ 7 × 1013 M⊙ clusters and with no false positives produced in our test region. Importantly, our method is positioned to create a watch list in advance of Rubin’s LSST, as it utilizes only existing data, therefore enabling the discovery of lensed transients early within the survey’s lifetime.
Cloudy with a chance of rain: accretion braking of cold clouds
Authors: Tan Brent , Oh S Peng , Gronke Max
Published: January 2023

Understanding the survival, growth, and dynamics of cold gas is fundamental to galaxy formation. While there has been a plethora of work on ‘wind tunnel’ simulations that study such cold gas in winds, the infall of this gas under gravity is at least equally important, and fundamentally different since cold gas can never entrain. Instead, velocity shear increases and remains unrelenting. If these clouds are growing, they can experience a drag force due to the accretion of low-momentum gas, which dominates over ram pressure drag. This leads to subvirial terminal velocities, in line with observations. We develop simple analytic theory and predictions based on turbulent radiative mixing layers. We test these scalings in 3D hydrodynamic simulations, both for an artificial constant background and a more realistic stratified background. We find that the survival criterion for infalling gas is more stringent than in a wind, requiring that clouds grow faster than they are destroyed ($t_{\rm grow} \lt 4\, t_{\rm cc}$). This can be translated to a critical pressure, which for Milky Way-like conditions is $P \sim 3000 \, {k}_\mathrm{ B} \, {\rm K}\, {\rm cm}^{-3}$. Cold gas that forms via linear thermal instability (tcool/tff < 1) in planar geometry meets the survival threshold. In stratified environments, larger clouds need only survive infall until cooling becomes effective. We discuss applications to high-velocity clouds and filaments in galaxy clusters.
Radiative turbulent mixing layers at high Mach numbers
Authors: Yang Yanhui , Ji Suoqing
Published: January 2023

Radiative turbulent mixing layers (TMLs) are ubiquitous in astrophysical environments, for example the circumgalactic medium (CGM), and are triggered by the shear velocity at interfaces between different gas phases. To understand the shear velocity dependence of TMLs, we perform a set of 3D hydrodynamic simulations with an emphasis on the TML properties at high Mach numbers $\mathcal {M}$. Since the shear velocity in mixing regions is limited by the local sound speed of mixed gas, high-Mach number TMLs develop into a two-zone structure: a Mach number-independent mixing zone traced by significant cooling and mixing, plus a turbulent zone with large-velocity dispersions which expands with greater $\mathcal {M}$. Low-Mach number TMLs do not have distinguishable mixing and turbulent zones. The radiative cooling of TMLs at low and high Mach numbers is predominantly balanced by enthalpy consumption and turbulent dissipation, respectively. Both the TML surface brightness and column densities of intermediate-temperature ions (e.g. O vi) scale as $\propto \mathcal {M}^{0.5}$ at $\mathcal {M} \lesssim 1$, but reach saturation ($\propto \mathcal {M}^0$) at $\mathcal {M} \gtrsim 1$. Inflow velocities and hot gas entrainment into TMLs are substantially suppressed at high Mach numbers, and strong turbulent dissipation drives the evaporation of cold gas. This is in contrast to low-Mach number TMLs where the inflow velocities and hot gas entrainment are enhanced with greater $\mathcal {M}$, and cold gas mass increases due to the condensation of entrained hot gas.
The SQUALO project (Star formation in QUiescent And Luminous Objects) I: clump-fed accretion mechanism in high-mass star-forming objects
Authors: Traficante A , Jones B M , Avison A , Fuller G A , Benedettini M , Elia D , Molinari S , Peretto N , Pezzuto S , Pillai T , Rygl K L J , Schisano E , Smith R J
Published: January 2023

The formation mechanism of the most massive stars is far from completely understood. It is still unclear if the formation is core-fed or clump-fed, i.e. if the process is an extension of what happens in low-mass stars, or if the process is more dynamical such as a continuous, multiscale accretion from the gas at parsec (or even larger) scales. In this context, we introduce the SQUALO project, an ALMA 1.3 and 3 mm survey designed to investigate the properties of 13 massive clumps selected at various evolutionary stages, with the common feature that they all show evidence for accretion at the clump scale. In this work, we present the results obtained from the 1.3 mm continuum data. Our observations identify 55 objects with masses in the range 0.4 ≤ M ≤ 309 M⊙, with evidence that the youngest clumps already present some degree of fragmentation. The data show that physical properties such as mass and surface density of the fragments and their parent clumps are tightly correlated. The minimum distance between fragments decreases with evolution, suggesting a dynamical scenario in which massive clumps first fragment under the influence of non-thermal motions driven by the competition between turbulence and gravity. With time gravitational collapse takes over and the fragments organize themselves into more thermally supported objects while continuing to accrete from their parent clump. Finally, one source does not fragment, suggesting that the support of other mechanisms (such as magnetic fields) is crucial only in specific star-forming regions.
Pulsations of primordial supermassive stars induced by a general relativistic instability; visible to JWST at z > 12
Authors: Nagele Chris , Umeda Hideyuki , Takahashi Koh , Maeda Keiichi
Published: January 2023

The origin of high-redshift quasars and their supermassive black hole engines is unclear. One promising solution is the collapse of a primordial supermassive star. Observational confirmation of this scenario may be challenging, but a general relativistic instability supernova provides one avenue for such. Previous studies have found that a general relativistic instability supernova has a potentially decades-long plateau phase visible to JWST at high redshift. In this work, we examine stars with mass just below the general relativistic instability supernova mass range. These stars pulsate, ejecting a portion of their envelopes. They then contract quasi-statically back to an equilibrium temperature, at which point they again become unstable and pulsate once more. Because each pulse consumes a small amount of the available nuclear fuel, there exists the possibility of multiple pulsations. We present simulations of the contracting phase, the pulsation, and the light-curve phase. We find that the lower mass pulsating models are even brighter than the higher mass supernovae because the pulsations occur in the late helium burning phase when the stars have extremely large radii. The fact that the pulsations are more luminous and occur in a wider mass range than the supernovae bodes well for observation.
Implementation of physical activity interventions for people with inflammatory arthritis: an overview and future recommendations
Authors: Cornwall Nicola , Swaithes Laura , Woodcock Charlotte , Healey Emma L , Hider Samantha L
Published: January 2023

Regular physical activity is important for both physical and mental health. This is particularly important for people with inflammatory arthritis, because of the benefits on both disease-specific and systemic outcomes and the increased risk of comorbidities such as cardiovascular disease. Despite a wealth of evidence supporting physical activity interventions, there remains a significant gap in implementation into routine care. This overview describes what implementation is, examines why it is important to consider implementation approaches to improve uptake of physical activity, highlights factors that influence successful implementation using exemplars from both osteoarthritis and inflammatory arthritis and recommends where future research is needed.
The challenge of exercise (non-)adherence: a scoping review of methods and techniques applied to improve adherence to physical activity and exercise in people with inflammatory arthritis
Authors: Chaplin Hema , Sekhon Mandeep , Godfrey Emma
Published: January 2023

Objectives

The aims were to explore the nature of methods/techniques applied to improve adherence to physical activity (PA) and exercise in people with inflammatory arthritis and to identify whether studies were theory based and/or used behaviour change techniques (BCTs).

Methods

Searches were undertaken of English language articles within four databases: Embase, Medline, PsycINFO and Cochrane. Articles were included if they assessed adherence to a PA and/or exercise intervention. A narrative synthesis of the findings is reported.

Results

Of 1909 studies screened, 18 studies met inclusion criteria. Adherence was most frequently included as a secondary outcome. Reporting of adherence measures was poor, in that 13 studies did not use a validated measure of adherence, with only three validated measures being identified. The majority of studies were not theory driven (n = 13), although the health belief model was the most used theoretical framework (n = 5). Only two studies mentioned both theory and BCTs. Four studies reported components that were mapped onto BCTs, with goal setting being the most prevalent.

Conclusion

This scoping review found that adherence to PA and/or exercise interventions was rarely the focus of research, despite its importance in maintaining health in people with inflammatory arthritis. Where research has been conducted in this area, serious shortcomings were revealed, in that psychological theory, evidence-based BCTs derived from theory and valid adherence measures were not used to inform intervention design and target adherence, meaning that interventions were suboptimal. These results suggest that there is considerable room for improvement and that more high-quality research is required to investigate determinants of adherence and develop impactful interventions.
Patient experiences of physical activity and exercise in rheumatoid arthritis
Authors: Canning Jordan , Williams Ruth , de Souza Savia
Published: January 2023

Lay Summary

What does this mean for patients?

Physical activity and exercise have been shown to have many benefits for people living with RA. These include improvements in symptoms associated with RA, such as pain, stiffness and fatigue. Participating in physical activity and exercise has also been shown to improve cardiovascular health and overall quality of life and is therefore an important part of disease management. Despite this, physical activity levels in people with RA are notably lower than those seen in people without RA, meaning that many RA patients do not experience the associated health benefits. By listening to the experiences of those with RA, researchers have been able to identify many of the reasons or barriers that make it harder for people with RA to exercise regularly. These include lack of professional support, feeling embarrassed or worrying about making symptoms worse. These important patient insights have also allowed researchers to understand other factors that support physical activity and exercise among people with RA, such as encouragement from family and friends and enjoying the feeling of achieving exercise-related goals. This paper includes the personal accounts of three patients with RA and their experiences with physical activity and exercise at different times: during childhood, during a flare and during a pandemic. Exploring the experiences of a wide range of patients is crucial in guiding the development of appropriate exercise-related advice and programmes that will support physically active lifestyles in this group of patients.
The challenges of measuring physical activity and sedentary behaviour in people with rheumatoid arthritis
Authors: Steultjens Martijn , Bell Kirsty , Hendry Gordon
Published: January 2023

The importance of sufficient moderate-to-vigorous physical activity as a key component of a healthy lifestyle is well established, as are the health risks associated with high levels of sedentary behaviour. However, many people with RA do not undertake sufficient physical activity and are highly sedentary. To start addressing this, it is important to be able to carry out an adequate assessment of the physical activity levels of individual people in order that adequate steps can be taken to promote and improve healthy lifestyles. Different methods are available to measure different aspects of physical activity in different settings. In controlled laboratory environments, respiratory gas analysis can measure the energy expenditure of different activities accurately. In free-living environments, the doubly labelled water method is the gold standard for identifying total energy expenditure over a prolonged period of time (>10 days). To assess patterns of physical activity and sedentary behaviour in daily life, objective methods with body-worn activity monitors using accelerometry are superior to self-reported questionnaire- or diary-based methods.
The role of microRNAs in regulating inflammation and exercise-induced adaptations in rheumatoid arthritis
Authors: Balchin Christopher , Tan Ai Lyn , Wilson Oliver J , McKenna Jim , Stavropoulos-Kalinoglou Antonios
Published: January 2023

MicroRNAs (miRNAs) are endogenously generated single-stranded RNAs that play crucial roles in numerous biological processes, such as cell development, proliferation, differentiation, metabolism and apoptosis. They negatively regulate target gene expression by repressing translation of messenger RNA into a functional protein. Several miRNAs have been implicated in the development and progression of RA. They are involved in inflammatory and immune processes and are associated with susceptibility to RA and disease activity. They are also considered to be potential markers of disease activity or even therapeutic targets. Likewise, several miRNAs are affected acutely by exercise and regulate exercise-related adaptations in the skeletal muscle and cardiovascular system and aerobic fitness. Interestingly, some miRNAs affected by exercise are also important in the context of RA. Investigating these might increase our understanding of the effects of exercise in RA and improve exercise prescription and, potentially, disease management. In this review, we focus on the miRNAs that are associated with both RA and exercise and discuss their roles in (and potential interactions between) RA and exercise-induced adaptations.
ESA-Ariel Data Challenge NeurIPS 2022: introduction to exo-atmospheric studies and presentation of the Atmospheric Big Challenge (ABC) Database
Authors: Changeat Quentin , Yip Kai Hou
Published: January 2023

This is an exciting era for exo-planetary exploration. The recently launched JWST, and other upcoming space missions such as Ariel, Twinkle, and ELTs are set to bring fresh insights to the convoluted processes of planetary formation and evolution and its connections to atmospheric compositions. However, with new opportunities come new challenges. The field of exoplanet atmospheres is already struggling with the incoming volume and quality of data, and machine learning (ML) techniques lands itself as a promising alternative. Developing techniques of this kind is an inter-disciplinary task, one that requires domain knowledge of the field, access to relevant tools and expert insights on the capability and limitations of current ML models. These stringent requirements have so far limited the developments of ML in the field to a few isolated initiatives. In this paper, We present the Atmospheric Big Challenge Database (ABC Database), a carefully designed, organized, and publicly available data base dedicated to the study of the inverse problem in the context of exoplanetary studies. We have generated 105 887 forward models and 26 109 complementary posterior distributions generated with Nested Sampling algorithm. Alongside with the data base, this paper provides a jargon-free introduction to non-field experts interested to dive into the intricacy of atmospheric studies. This data base forms the basis for a multitude of research directions, including, but not limited to, developing rapid inference techniques, benchmarking model performance, and mitigating data drifts. A successful application of this data base is demonstrated in the NeurIPS Ariel ML Data Challenge 2022.
RADIATION DOSE OF THE EYE LENS IN CT EXAMINATIONS OF THE BRAIN IN CLINICAL PRACTICE—THE EFFECT OF RADIOGRAPHER TRAINING TO OPTIMISE GANTRY TILT AND SCAN LENGTH
Authors: Tarkiainen Jeremias , Nadhum Miia , Heikkilä Annele , Rinta-Kiikka Irina , Joutsen Atte
Published: January 2023

Lenses are always exposed to radiation in brain computed tomography (CT) scans. However, the lens dose can be reduced by excluding lens from scanning area by optimising gantry tilt and scan length. The object of this study is to retrospectively analyse if the optimisation by gantry tilt and scan length have been adequate in the CT scan of the brain, and to prospectively analyse the effect of radiographer training to the quality of the CT examinations. This study was conducted in two parts. In all, 329 brain CTs performed in the Tampere University Hospital from 2017 to 2019 were revised retrospectively. The prospective part included 51 brain CT studies conducted in October 2021. Dose to the eye of the lens was modelled using CT-Expo using zero-degree beam angle and scan lengths to expose the lens either to the primary or scattered radiation. Non-zero gantry tilt had been used in a large proportion of the CT examinations in the retrospective setting, 84.8%. However, the lenses were successfully excluded from the scan area in only 1.8% of the examinations. In the prospective part, the gantry tilt was used in 98% of the studies and the proportion of successful examinations rose from 1.8 to 11.8%. The lens dose decreased significantly when the eyes were excluded from the imaging area. The modelled lens dose in the large retrospective part was 25.9 mGy (17.8–49.2 mGy) when the eyes were included and 1.5 mGy (0.4–1.9 mGy) when the eyes were excluded. The lens dose was similar in the small prospective part. Despite the gantry tilt is widely used, unnecessary lens irradiation occurs extensively because of suboptimal gantry tilt and scan length. The training of radiographers reduces the radiation exposure to the lens by more optimal gantry tilt and scan length.
Differential Effects of Clozapine and Haloperidol on the 40 Hz Auditory Steady State Response-mediated Phase Resetting in the Prefrontal Cortex of the Female Sprague Dawley Rat
Authors: Ummear Raza Muhammad , Gautam Deepshila , Rorie Dakota , Sivarao Digavalli V
Published: January 2023

Background

Neural synchrony at gamma frequency (~40 Hz) is important for information processing and is disrupted in schizophrenia. From a drug development perspective, molecules that can improve local gamma synchrony are promising candidates for therapeutic development.

Hypothesis

Given their differentiated clinical profile, clozapine, and haloperidol may have distinct effects on local gamma synchrony engendered by 40 Hz click trains, the so-called auditory steady-state response (ASSR).

Study Design

Clozapine and haloperidol at doses known to mimic clinically relevant D2 receptor occupancy were evaluated using the ASSR in separate cohorts of female SD rats.

Results

Clozapine (2.5–10 mg/kg, sc) robustly increased intertrial phase coherence (ITC), across all doses. Evoked response increased but less consistently. Background gamma activity, unrelated to the stimulus, showed a reduction at all doses. Closer scrutiny of the data indicated that clozapine accelerated gamma phase resetting. Thus, clozapine augmented auditory information processing in the gamma frequency range by reducing the background gamma, accelerating the gamma phase resetting and improving phase precision and signal power. Modest improvements in ITC were seen with Haloperidol (0.08 and 0.24 mg/kg, sc) without accelerating phase resetting. Evoked power was unaffected while background gamma was reduced at high doses only, which also caused catalepsy.

Conclusions

Using click-train evoked gamma synchrony as an index of local neural network function, we provide a plausible neurophysiological basis for the superior and differentiated profile of clozapine. These observations may provide a neurophysiological template for identifying new drug candidates with a therapeutic potential for treatment-resistant schizophrenia.
Characterization of Uromyces appendiculatus First Races in Sri Lanka and Identification of Genes for the Development of Rust-Resistant Snap Beans
Authors: Kumari H. M. P. S. , Pastor Corrales Marcial A. , Rajapaksha R. G. A. S. , Bandaranayake P. C. G. , Weebadde Cholani
Published: January 2023

Bean rust is a devastating disease of snap beans in Sri Lanka. Our study endeavored to develop snap beans with resistance to Uromyces appendiculatus, the bean rust pathogen reported to have numerous virulent races. Accordingly, we needed a detailed understanding of the virulence of U. appendiculatus and to identify genes conferring effective rust resistance. To investigate the virulence, we collected leaves of snap bean with rust symptoms from four snap bean producing districts of Sri Lanka. From these samples we established 57 single pustule isolates. Each isolate was inoculated on a set of 12 differential cultivars, six from the Andean and six from the Middle American gene pools of common bean. The virulence of the isolates segregated into four distinct groups that comprised the first four reported races of U. appendiculatus in Sri Lanka, 23-5, 31-1, 31-11, and 63-21. All races were significantly more virulent on the Andean than on the Middle American differential cultivars. PI 1819966, a Middle American differential cultivar containing the Ur-11 gene, conferred resistance to all four races. Three other Middle American cultivars were resistant to three races. Conversely, five Andean differential cultivars were susceptible to all four races. PI 160418 was the only Andean differential cultivar with resistance to three races. The results suggested that rust resistance genes from the Middle American differential cultivars could be combined in different ways with the resistance of Andean PI 260418 to develop snap bean varieties with broad resistance to all races of U. appendiculatus in Sri Lanka.
Bioactivity and Control Efficacy of Benzovindiflupyr Against Athelia rolfsii in China
Authors: Sun Longjiang , Na Risong , Jiang Chaofan , Cui Kaidi , He Ya , Zhao Te , Zhang Jingjing , He Leiming , Zhou Lin
Published: January 2023

Athelia rolfsii is a devastating soilborne pathogen that causes stem rot of peanut and severely restricts peanut production. The new generation of succinate dehydrogenase inhibitor (SDHI) fungicide benzovindiflupyr has been registered in the United States and Brazil for managing multiple plant diseases. However, it is not registered in China to control peanut stem rot. In this study, 246 isolates from major peanut production areas in Shandong, Henan, and Hebei Provinces of China were used to determine the baseline sensitivity of A. rolfsii to benzovindiflupyr. The frequency of EC50 values of benzovindiflupyr was unimodally distributed with an average EC50 of 0.12 ± 0.05 mg/liter and a range of 0.01 to 0.57 mg/liter. Benzovindiflupyr can also strongly inhibit the germination of sclerotia, with an average EC50 of 2.38 ± 1.04 mg/liter (n = 23). In addition, benzovindiflupyr exhibited great in vivo efficacy against A. rolfsii; the protective or curative efficacy (89.87%, 20.39%) of benzovindiflupyr at a concentration of 50 mg/liter was equivalent to that of the control fungicide thifluzamide at 100 mg/liter (86.39%, 16.21%). At the same concentration (e.g., 100 mg/liter), the protective efficacy (93.99%) of benzovindiflupyr was more than twice as high as the curative efficacy (45.07%). A positive correlation existed between benzovindiflupyr and isopyrazam or mefentrifluconazole, which possibly resulted from similar chemical structures or damage to the cell membrane. Our findings provide valuable information for the application of benzovindiflupyr, and the established baseline sensitivity could facilitate the monitoring and assessment of benzovindiflupyr resistance risk.
Complete Genome Sequence of Pantoea ananatis Strain LCFJ-001 Isolated from Bacterial Wilt Mulberry
Authors: Yuan Ting , Huang Yuxing , Luo Longhui , Wang Jicheng , Li Jinhao , Chen Jiehu , Qin Yue , Liu Jiping
Published: January 2023

A Pantoea ananatis strain, named LCFJ-001 (GDMCC: 1.6101), was isolated for the first time from bacterial wilt-diseased roots of mulberry (Morus atropurpurea) in the western part of the Guangxi Zhuang Autonomous Region, China. Moreover, through Koch’s postulates, it was proven that LCFJ-001 can cause mulberry wilt, which is one of the pathogens of mulberry bacterial wilt. Here, we report a complete, annotated genome sequence of P. ananatis LCFJ-001. The entire genome sequence of P. ananatis strain LCFJ-001 was a 4,499,350 bp circular chromosome with 53.50% GC content. In total, 3,521 genes were annotated, of which 3,418 were assigned protein-coding genes. In addition, 22 ribosomal RNAs and 81 transfer RNAs were identified. The presented resource will help explore the pathogenetic mechanisms of mulberry wilt disease caused by the genus Pantoea.
Building Team Leader Competency in Senior Nursing Students
Authors: Fetters Lisa , Wilson Kristi , Johns Edgar F. , Streetman Ronald , Turkelson Carman
Published: January 2023

Nursing students have limited opportunities to build team leader skills during their clinical experiences, leaving a practice gap. Senior nursing students participated in a competency-based education unit and a simulation-based learning experience incorporating team leader skills. Presurvey and postsurvey data were collected using the Self-Confidence and Comfort with Utilizing a Standardized Handoff Communication Tool. Participants who completed both surveys were analyzed (n = 85). Statistically significant improvements were found on 14 of the 19 survey items. Results suggest the effectiveness of using competency-based education and simulation-based learning experience to help nursing students build confidence and comfort in team leader skills.
Comparison of Intratympanic Steroid and Hyperbaric Oxygen Salvage Therapy Hearing Outcomes in Idiopathic Sudden Sensorineural Hearing Loss: A Retrospective Study
Authors: Ajduk Jakov , Peček Mirta , Kelava Iva , Žaja Roko , Ries Mihael , Košec Andro
Published: January 2023

Objectives:

Systemic steroids are the most common first-line therapy in sudden sensorineural hearing loss (SSNHL), with significant improvement in hearing outcomes in over 60% of patients. It is unknown why 40% of patients do not respond to systemic steroid therapy. Salvage treatment includes intratympanic steroids (ITS) and hyperbaric oxygenation (HBO) therapy, with inconsistent results reported. This study aimed to compare the results of ITS and HBO therapy in patients with SSNHL that previously failed systemic steroid therapy.

Design:

This is a comparative retrospective nonrandomized interventional cohort study, enrolling 126 patients with SSNHL. Out of these, 35 patients received HBO therapy, 43 patients received ITS, and 48 patients did not receive any second-line therapy (control group). Pure-tone audiograms were performed before and after the salvage therapy in the IT and HBO groups and at the same time interval in the control group. Study variables included age, time until therapy initiation, tinnitus status, and hearing outcomes, with a cutoff criteria of cumulative >30 dB improvement on all frequencies indicating recovery.

Results:

ITS and HBO therapy were associated with statistically significant hearing recovery at all frequencies compared to systemic steroids. The results show an average hearing improvement of 13.6 dB overall frequencies (250 to 8000 Hz) after ITS therapy and 7.4 dB in HBO therapy in comparison to the control group. Presence of significant hearing improvement positively correlated with age, ITS therapy, and HBO therapy. Presence of tinnitus before therapy was negatively correlated with hearing improvement. Patients with tinnitus present at the start of therapy improve 4.67 dB less on average compared to those without tinnitus. ITS therapy significantly reduced tinnitus compared to the other two treatment options. Patients with tinnitus present before therapy significantly improve hearing at low frequencies, compared to the control group.

Conclusions:

ITS and HBO therapy show superior hearing results compared to observation alone after failed oral steroid therapy for SSNHL. ITS shows an additional positive impact on tinnitus reduction and shows superior hearing outcomes after salvage therapy.
HER2-low expression in breast oncology: treatment implications in the smart chemotherapy era
Authors: Giugliano Federica , Curigliano Giuseppe , Tarantino Paolo
Published: January 2023

Human epidermal growth factor 2 (HER2)–low breast cancers, defined as tumors exhibiting a HER2 IHC score of 1+ or 2+ nonamplified, represent an emerging targetable entity in the clinicopathologic landscape of breast cancer. Traditionally considered as not sensitive to HER2-targeting agents, these tumors have shown to be susceptible to a new class of drugs, namely antibody-drug conjugates (ADCs). Indeed, the DESTINY-Breast04 phase 3 trial demonstrated the remarkable activity of trastuzumab deruxtecan for treating both hormone-receptor (HR)–positive and triple-negative metastatic breast cancers that show HER2-low expression, reshaping treatment algorithms for these diseases. Concomitantly, the TROPiCS-02 and the ASCENT phase 3 trials have established the role of the anti-Trop-2 ADC sacituzumab govitecan for HR-positive and triple-negative breast cancer, respectively. A careful evaluation of these trials, with their inclusion/exclusion criteria, efficacy and toxicity results, is required in order to understand how best to treat HER2-low metastatic breast cancer in the context of a rapidly evolving therapeutic landscape. The purpose of this narrative review is to recapitulate the available evidence on the use of ADCs in the treatment of HER2-low breast cancer, providing a perspective on their current role in clinical practice.