bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS KAUSALITAS DANA DESA, PEMBANGUNAN INFRASTRUKTUR, DAN KESEJAHTERAAN MASYARAKAT DI KECAMATAN GONDANGREJO KABUPATEN KARANGANYAR
Authors: Sukma Egidea Amengku , Puspitasari Inda Fresti
Published: July 2023

All villages in Gondangrejo District are classified as self-sufficient villages, have a well-known agricultural sector, have high-quality industrial areas, are quite large, and function as economic developers. However, because the carrying capacity of infrastructure is very low due to the absorption capacity used for handling Covid-19, many roads have been damaged and connections between villages have not been tendered. This study aims to observe the pattern of causality between infrastructure, village funds and the level of community welfare in Gondangrejo District, Karanganyar Regency in 2017-2021. This study uses the Granger Causality Test method. In the Granger Causality test, the data requirements used are stationary data. The results of the Granger Causality Test state that there is a one-way causality relationship between the level of welfare affecting village funds and a two-way causality between village funds causing or influencing infrastructure and vice versa. Based on these results, it is hoped that the village government can pay more attention and study more in the management of village funds. Further review needs to be carried out in carrying out the infrastructure development needed by the community, so that the absorbed village funds will produce infrastructure that is directly useful for the economic activities of the villagers.
PENGUKURAN INDEPENDENSI BANK INDONESIA SELAMA COVID-19
Authors: Puspitasari Inda Fresti , Sari Dhany Efita , Masitoh Siti
Published: July 2023

Central bank independence in Indonesia has been regulated in UU No. 33 Year 2004 concerning amendements to UU No. 23 Year 2009 concerning Bank Indonesia. However, the central bank often got intervention in formulating its policies. During the pandemic covid-19 crisis, there were several attempts to intervene Bank Indonesia, such as the idea to form a Monetary Council, suggestions to allow BI Governors from politicians, and Perppu No. 1 Year 2020 which is allow BI to bought SUN in the primary market. Therefore, this study aims to measure the independence index of the central bank in Indonesia during 2007-2020 using the measurement method developed by Cukierman et al. (1994) to analyze the independence of Bank Indonesia during the covid-19 pandemic. The result of this study proves that BI independence index during the pandemic has decreased when compared to the pre-pandemic period. This study also proves that Bank Indonesia still needs to maintain its independence from all political attention, so its accountability and credibility of the monetary policy still can assured
THE IMPLEMENTATION OF HALAL TOURISM IN STARE MIASTO (OLD TOWN) IN THE VIEW OF INTERNATIONAL TOURISTS, ACCEPTANCE AND REJECTION?
Authors: Supriadi Herman , Nalazek Miroslaw , Rahadi Irwan
Published: July 2023

This research is a quantitative descriptive research that consists of fifty samples. The sample respondens were chosen from several countries. they were chosen randomly and have visited Old Town. Old town is chosen because of its popularity. The data collection used was questionnaires which are shared in two ways (online and offline). Then the questionnaires were collected and tabulated to find the percentage of respondents’ acceptance and rejection to the implementation of Halal tourism in Old Town (Stare Miasto). Due tot to the implementation of Halal tourism in Old Town (Stare Miasto) according to the result percentage of all respondents results from the respondents agree to the implementation of Halal tourism in Old Town with half of the percentage. Though some percentages also are neutral and disagree to the implementation with more than one four of the percentage. Thus, the implementation of Halal tourism in Poland is accepted by tourists.
THE ROLE OF ENTREPRENEURSHIP LEARNING IN GROWING STUDENT ENTREPRENEURIAL INTEREST
Authors: Irawan Purna , Purwandari Elce , Ratu Liliany Purnama , Khoirudin Ahmad , Iskandar Erwan
Published: July 2023

Entrepreneurship is frequently defined as the act of developing something with the intention of adding value to the economy. The results of entrepreneurship can be found in both products and services. Lessons in entrepreneurship should be taught in higher institutions since they are predicted to be able to lower the high unemployment rate, particularly among educated people. In addition, innovative concepts and the most recent advancements are anticipated to surface to encourage student interest in entrepreneurship. MSMEs, the engine of the economy, are the entrepreneurial sector that is currently in the spotlight. Because the time required to manage a business is more flexible and can be self-regulated according to demands, so it doesn't conflict with study time, students can participate as MSME players. Using a sample of 56 students as respondents, this study intends to ascertain the contribution of entrepreneurship learning in generating interest in entrepreneurship among students at the Al-Azhaar Lubuklinggau Islamic Institute. A survey is the quantitative method that was used. By sending online surveys in the form of Google Forms with a Likert scale ranging from 1 to 4, data was gathered. Both quantitative and descriptive data analysis was done. According to the study's findings, entrepreneurship education helps students develop an interest in the field
Retos en el horizonte de la educación superior
Authors: Ureña Prado Yaqueline Elizabeth , Marroquín Yerovi Marianita
Published: July 2023

En el campo educativo se ha experimentado en la actualidad, grandes transformaciones; las universidades han dado una transición de lo tradicional a la modernidad, en búsqueda de un sentido que haga frente a la realidad vigente. Durante las últimas décadas se evidencia notables cambios que han llevado al tránsito de universidades de élite a universidades de masas, con la llegada masiva de estudiantes a sus aulas, lo que ha provocado una diversidad nunca vista en el alumnado y que, ha llevado a introducir el componente digital en todos sus ámbitos docentes, de investigación, de administración y de gestión, respondiendo a las exigencias de una sociedad que ha dejado de ser, definitivamente, analógica, para abrazar de forma decidida la virtualidad. A todo ello, por si esto fuera poco, las tendencias globalizadoras en la educación superior han impulsado una reforma: el Proceso de Bolonia, que ha supuesto el mayor desafío para la universidad de la época contemporánea
Estrategias de codificación en el proceso de aprendizaje de estudiantes universitarios
Authors: Marroquín Yerovi Marianita , Ureña Prado Yaqueline Elizabeth
Published: July 2023

El artículo que se comparte con la comunidad académica nacional e internacional en el ámbito de la educación superior, es el resultado de un proceso de investigación, como una oportunidad de profundizar en estrategias de aprendizaje desde varios puntos de vista y ejecuciones mediante la participación de estudiantes, cuyos objetivos fueron una respuesta a una pregunta que incomodó a docentes y directivos en cuanto a la causa de la cantidad considerable de estudiantes que debieron habilitar los cursos desde diferentes áreas del conocimiento. Los estudiantes participantes en la investigación, que resolvieron las escalas, fueron matriculados en el segundo semestre del año 2018. Se aplicaron las escalas de Adquisición, Codificación, Recuperación y Apoyo. Los resultados que se está publicando corresponden a la Codificación, la segunda escala, que responde al objetivo de esta participación académica. El diseño metodológico corresponde al proceso cuantitativo, dando como resultado, las correspondientes tablas dinámicas. Las escalas contienen una serie de afirmaciones sobre las cuales se debió asumir desde la experiencia personal, sobre el proceso de aprendizaje, la manera de estudiar y otras experiencias. Entre los resultados, los porcentajes mayores corresponden a las estudiantes sobre los estudiantes.
Formación docente con enfoque en la educación contemporánea en el Ecuador
Authors: Rodríguez Quiñónez Víctor Manuel , Rodríguez Quiñónez Ángel Francisco , Bazán Collis Janina Elizabeth
Published: July 2023

El objetivo del artículo fue describir la formación docente con enfoque en la educación contemporánea en el Ecuador. En la recolección de la información, la observación fue una técnica primordial para detectar en el cuerpo docente de las instituciones educativas, aquellos que no poseen título universitario o tecnológico en educación. Este hecho fue corroborado con la investigación documental, en especial, por la información del Ministerio de Educación. Entre los hallazgos se evidenció que son rescatables los esfuerzos de superación que realizan los docentes, siendo recompensados con los cambios actuales en la educación, enfocados al mejoramiento profesional e incremento salarial para lograr un mejor nivel de vida, por lo cual se concluye que estos deben contar con la información oportuna y adecuada de los estilos aprendizajes de los estudiantes, así como el tipo de inteligencia afín y, conocer los métodos y técnicas a aplicar en el aula.
Nuevas experiencias de aprendizaje del inglés con Storytelling y Proyecto Integrador
Authors: Montenegro Cevallos Montenegro Cevallos
Published: July 2023

Tras la pandemia del COVID-19, la educación ha sufrido drásticas transformaciones, especialmente en la forma de gestionar aprendizajes que propicien experiencias vivenciales. La Pontificia Universidad Católica del Ecuador sede Ibarra y su carrera de Pedagogía de los Idiomas Nacionales y Extranjeros, conscientes de esta nueva realidad, han implementado nuevas estrategias educativas con Storytelling y Proyecto Integrador para mejorar la formación integral de los estudiantes. En este contexto, el objetivo de este trabajo es mostrar los resultados obtenidos con esta tipología de aprendizaje que tuvo como fin, identificar las metodologías de enseñanza del idioma inglés que se emplea en un contexto educativo rural después de la pandemia; para ello, se ha utilizado un enfoque cuali-cuantitativo, con entrevistas y un cuestionario. La población objeto de estudio fueron estudiantes de tercer año de bachillerato, la profesora de la asignatura de inglés y la rectora de la Unidad Educativa Zuleta, ubicada en Imbabura, Ecuador. Los resultados indican que, en la ruralidad se emplea metodologías activas para la enseñanza del inglés, vinculadas a un aprendizaje práctico que permite la comunicación efectiva y eficaz en inglés. Finalmente, se expone conclusiones que podrían ser tomadas en cuenta para futuras investigaciones
Árbol ABC, recurso digital para la enseñanza y aprendizaje de las tablas de multiplicar del 6 al 10 en el grado segundo
Authors: Buitrago Quesada Yudy Paola , Rodríguez Salinas Deisy Daniela , Cifuentes Medina José Eriberto
Published: July 2023

El presente trabajo de indagación quiere patentar y exponer, por medio de secuencias didácticas, una estrategia significativa en las matemáticas y, a su vez, interrelacionarla con los recursos educativos digitales, en aras de equilibrar el contenido en los estudiantes de segundo de primaria. La investigación tuvo como objetivo, identificar en los estudiantes la enseñanza y aprendizaje en las tablas de multiplicar del 6, 7, 8, 9 y 10 por medio de la ludificación, con el recurso educativo Árbol ABC, donde el intercambio de las actividades didácticas y vivenciales y no mecanizadas llevó a una buena instrucción de las mismas; por ello, es importante enseñar y fortalecer dichos saberes, con el propósito que se persigue al aplicar los recursos educativos digitales en la enseñanza, generando nuevas epistemologías y, a su vez, promoviendo la formación significativa, facilitando en el estudiante su desarrollo, habilidad y capacidades autónomas.
Determinan Keputusan Nasabah Menabung di BTN Syariah KC Solo dengan Minat Sebagai Variabel Intervening
Authors: Cahyani Ajeng Regita , Guritno Agung
Published: July 2023

The purpose of this study was to determine the factors that influence customer decisions to save at Islamic banks with customers interest as an intervening variable. The research method uses an associative descriptive quantitative approach. The number of samples was 100 respondents of Islamic bank customers. data collection techniques using questionnaires. The results showed that profit sharing rate, bank reputation, religiosity and interest directly had a positive effect on customer saving decisions at BTN Syariah. Then the profit sharing rate, reputation and religiosity have a positive effect on customer interest in saving at BTN Syariah. Interest variables are also unable to mediate the effect of profit sharing rate, reputation and religiosity on customer decisions indirectly
Determinant Factors Of Profitability Of Islamic Banks In 2017-2021 With Capital Adequacy Ratio As a Variable Intervening
Authors: Wita Sari Eka , Irvani Ahmad , Meilani Reka , Cipta Hendra
Published: July 2023

This study aims to analyze the effect of Non Performing Financing (NPF) and Finance to Deposit Ratio (FDR) on Islamic bank profitability mediated by Capital Adequacy Ratio (CAR). This study uses secondary data in the form of panel data (pooled data), which is a combination of cross section data and time series data. The analysis technique uses path analysis. The results showed that FDR has no influence on CAR while NPF affects the CAR of Islamic banks. FDR and NPF directly have no influence on the ROA of Islamic banks. CAR variable is only able to be intervening between NPF and ROA while FDR variable indirectly through CAR variable has no significant effect on ROA of Islamic banks.
Peran BMT Al Makmur Dalam Mewujudkan Ketahanan Ekonomi Keluarga Miskin
Authors: Mariko Suhatri
Published: July 2023

This study aims to analyze the role of the Sharia Microfinance Institution BMT Al Makmur in efforts to realize the economic resilience of poor families. This type of research is field research with a qualitative descriptive approach. The data sources are BMT Al Makmur Leaders and Murabahah Financing Customers. Data collection techniques are interviews and documentation. Data analysis techniques are carried out through data reduction, data display and conclusion drawing. The results showed that the presence of BMT Al Makmur as a Sharia Microfinance Institution has had a positive impact on realizing economically resilient families by managing family economic risks for the future. Through murabahah financing channeled for the purpose of purchasing gold which is used as a medium for saving money by customers, because it is believed that investment through gold is a safe and profitable investment category. The gold is used as a reserve to anticipate and fulfill needs for the future, such as the need for children's education costs, and to make their own homes.
Gambaran Kualitas Hidup Pasien Post Operasi Katarak di Poliklinik RS Mata Bali Mandara Provinsi Bali
Authors: Ariani Ni Made , Dewi Ni Luh Putu Thrisna , Antara Dewa Kadek Adi Surya
Published: July 2023

Gangguan terhadap penglihatan masih banyak terjadi di masa pandemi COVID-19, mulai dari gangguan penglihatan ringan hingga kebutaan adalah masalah yang cukup serius terjadi di seluruh dunia termasuk di Indonesia. Penyebab utama kebutaan di dunia dan juga sebagai penyebab utama kebutaan tertinggi di Indonesia dengan ketajaman visual kurang dari 6/60 adalah penyakit katarak. Riset memiliki tujuan untuk mengetahui gambaran kualitas hidup pasien post operasi katarak di Poliklinik RS Mata Bali Mandara. Desain pada riset ini menggunakan deskriptif kuantitatif dengan cross sectional. Sampel riset ini menggunakan consecutive sampling dengan jumlah 130 orang. Hasil dari riset ini adalah ditemukan data karakteristik yaitu responden terbanyak berada pada kategori usia manula (>65 tahun) yaitu 54 responden (41,5%), dominan dengan jenis kelamin perempuan yaitu sebanyak 92 responden (70,8%) dan berada dalam kategori pendidikan menengah (Perguruan SMP/SMA) yaitu sebanyak 63 responden (48,5%) dan mempunyai kualitas hidup pada kategori baik yaitu sebanyak 83 responden (63,8%). Ke depannya dari pihak rumah sakit agar lebih memberikan penjelasan yang lebih detail dari awal sebelum operasi dan tolak ukur keberhasilan serta kemungkinan yang terjadi.
Food and medicinal plants from Nigeria with anti-Helicobacter pylori activities induce apoptosis in colon and gastric cancer cell lines
Authors: Lawal Temitope O. , Patel Shitalben R. , Mahady Gail B.
Published: July 2023

Background: Food and medicinal plants are used traditionally in Nigeria to treat gastrointestinal (GI) disorders such as gastritis, peptic ulcer disease and GI-related cancers. We have previously reported that specific extracts of Nigerian food and medicinal plants inhibited the growth of Helicobacter pylori, a bacterium known to cause peptic ulcer disease, as well as gastric and colon cancer. Objective: To determine the effects of three food plants, namely Anogeissus leiocarpus (DC.) Guill. & Perr.  (African birch, Combretaceae), Terminalia glaucescens Planch ex Benth. (Nigerian chewing sticks, Combretaceae) and Dillenia indica L. (Elephant apple, Dilleniaceae) used in Nigeria for the treatment of GI disorders and cancer in six colon and gastric cancer cell lines, and two non-cancerous cell lines. Methods: Cancer cells were grown in appropriate media and CellTiter-Glo® 2.0 and ApoTox-Glo™ Triplex assays were used to measure cell growth and apoptosis in SW480, SW620, HCT116, Caco2 cell lines, as well as  AGS and NCI-N87 gastric cancer cells. Caspase-Glo® 3/7, and Caspase-Glo® 8 were used to determine caspase activities and apoptosis. Gene expression was measured using quantitative PCR.Results: The methanol extract of A. leiocarpus roots inhibited the growth of HCT-116, SW480 and SW620 colon cancer cells (IC50 of 15.8, 10.0, and 20.8 µg/mL, respectively), but weakly active in the AGS and NCI-N87 cells (IC50 77.0 and >100 µg/mL respectively). The T. glaucescens extract was weakly active in HCT-116 cells (IC50 64.9 µg/ml) and AGS cells (52.2 µg/ml). The D. indica extract was active in SW480 (IC50 15.8 µg/mL), and weakly active in Caco2 (IC50 35.2 µg/mL) and HCT-116 (IC50 53.2 µg/mL). In HCT-116 cells, A. leiocarpus root extract and its aqueous partition increased caspase 8 activity, as well as mRNA expression of p53, while expression of Bcl-2 and HDAC1 mRNA was reduced. Bioassay guided fractionation of the aqueous partition led to the isolation and identification of the known compound methyl gallate.Conclusions: These data suggest that the Nigerian food plants with anti-Helicobacter pylori activities increase the expression of the tumor suppressor p53 and inhibit HDAC1, thereby inducing apoptosis in HCT-116 colon cancer cells.Running Title: Inhibitory Effects of Nigerian food plants on GIT CancersKeywords: African birch, AGS, Apoptosis, Anogeissus leiocarpus, Dillenia indica, Elephant apple, Terminalia glaucescens, Nigerian chewing sticks, HCT-116, SW480, SW620
Nalar Kritis Pemikiran Omar Mohammad Al-Toumy Al-Syaibany dan Relevansinya dengan Pendidikan Bahasa Arab Berbasis MBKM
Authors: Putra Wahyu Hanafi , Siregar Maragustam
Published: July 2023

This study aims to describe the critical thinking of Al-Syaibany and its relevance to MBKM-based Arabic Language Education. This research is qualitative with a library research model. The results of the study show, first, that the implementation of Merdeka Learning is by the nature of the Islamic education curriculum, its characteristics, and its objectives. Every activity students study is a derivative of a planned curriculum. Second, the MBKM curriculum paradigm leads to the formation of students' knowledge of critical thinking and students' Arabic language skills. Two steps can be formed with the conditions of the learning environment, which can make students self-aware always to learn. Third, the design of the MBKM curriculum in the PBA Study Program is a reconstruction of the KKNI 2016.
Cash Flows, Earnings, and Dividend Payout Nexus in Pakistan: A Case Study of KSE-100 Index
Authors: Riaz Khadija , Sheikh Muhammad Ramzan , Hussain Irfan , Mushatq Muhammad Imran
Published: July 2023

The nexus between cash flows, earnings, and dividend payout in Pakistan holds paramount importance for investors. It enables them to assess the financial health and stability of companies listed on the Karachi Stock Exchange-100 (KSE-100) Index, make informed investment decisions, and manage risks effectively. Therefore, the current study discusses the importance of dividends in corporate finance and the factors that affect the dividend payouts, particularly in the context of Pakistani listed companies in the Pakistan Stock Exchange (PSX). The contradictory nature of dividends has made it a fundamental issue of corporate finance, which has been studied in relation to a firm’s investment and financing decisions as prime variables. This study has found that earnings per share and free cash flow affect the level of dividends in the surveyed companies, with earnings per share having a positive but insignificant impact on the dividend per share. Profitability has a positive effect on dividend payout; however, there is no significant effect of earnings per share on the dividend. The findings enhance the current body of literature by providing insights into the determinants of dividend payout among the Pakistani listed companies. Furthermore, these findings are valuable for investors decision-makers, and policy makers, which make informed investment decisions. The study also identified problems for management and investors and other researchers who are conducting different studies to assess firm behaviour regarding payout decisions with possible solutions and future implications.
Anti-fatigue effect of ferulic acid in exercise trained mice
Authors: LIU XIANCHU , LIU MING
Published: July 2023

Ferulic acid (FA) was proved to have various pharmacological characteristics in muscle function. Fatigue is closely linked with muscle dysfunction. However, the correlation between fatigue and FA is unclear. Hence, our aim was to appraise anti-fatigue property of FA in exercise trained mice. Our results displayed FA enhanced exhaustion time and grip strength to postpone fatigue. In excessive exercise, FA reduced serum CK, LDH, ALT and AST levels to protect against liver and muscle damage. In liver and muscle, FA improved glycogen contents to increase substance of energy source. In skeletal muscle, FA restrained oxidative stress by accelerating SOD, CAT and GSH-PX activites, and mitigating MDA level. Moreover, FA also attenuated inflammatory response by decreasing TNF-a and IL-6 levels. Lastly, FA ameliorated energy metabolism by increasing Na+-K+-ATPase and SDH activities. In conclusion, FA protected against excessive exercise-fatigue through improvement of energy supply, oxidative stress, inflammatory response and energy metabolism-correlated enzymes.
Comparative characteristics of newly diagnosed adult diabetic patients: a pilot study.
Authors: Sokolowska Emilia , Car Halina , Szelachowska Małgorzata , Adamska Agnieszka , Wawrusiewicz-Kurylonek Natalia , Szumowski Piotr , Kossakowska-Malinowska Paulina , Bajkowska Diana , Podgórska Beata , Wielogórska Marta , Lisiewicz Paulina , Supronik Jakub , Popławska-Kita Anna , Żendzian-Piotrowska Małgorzata , Chabowski Adrian , Krętowski Adam , Siewko Katarzyna
Published: July 2023

Diabetes is one of the most common chronic diseases. Early and improved classification of the type of diabetes, whether autoimmune (type 1 diabetes mellitus, T1DM, and latent autoimmune diabetes, LADA) or type 2 diabetes mellitus (T2DM), is essential to determine appropriate therapy. We aimed to present the biochemical and immunological characteristics of adult patients with newly diagnosed diabetes without prior drug treatment. This pilot, a cross-sectional study assessed major phenotypic characteristics and antibody titers, including islet cell antibodies (ICA), insulin autoantibodies (IAA), tyrosine phosphatase antibodies (IA-2A), glutamic acid decarboxylase antibodies (GADA), zinc antibodies (ZnT8A), but also selected sphingolipids belongs to ceramides (Cer) and sphingomyelin (SM). A total of 59 participants were included: 21 with T1DM, 15 with T2DM, and 23 with LADA. Saturated fatty acids chain Cer such as Cer-C22:0 and Cer-C24:0 positively correlates with total cholesterol (TC), triglycerides (TC), and low-density lipoprotein cholesterol (LDL), particularly in autoimmune diabetes (LADA, T1DM) while in T2DM group we found a higher frequency of positive correlation only between Cer-C24:0 and TC. In LADA patients, SM-C18:1 and -C:20:4 values rise with increasing fasting and glucagon-stimulated C-peptide values. The prevalence of GADA in patients diagnosed with T1DM is higher in younger patients versus older ones. While patients with LADA were more likely to test positive for multiple (>4) antibodies. In this relatively small cross-sectional study adult patients with newly diagnosed diabetes have fluctuating clinical and metabolic features with variable severity of immune dysfunction, making it easier to diagnose patients.
Analysis of women's eating behaviours in home isolation due to COVID-19 in the context of the dietary impact on the course of the disease
Authors: Górska Paulina , Górna Ilona , Miechowicz Izabela , Przysławski Juliusz
Published: July 2023

The aim of the study was to collect and analyse data on people's eating behaviours and physical activity in home isolation due to a SARS-CoV-2 infection. In addition, the purpose of the study was to show how taste and smell disturbance can affect eating behaviours. Identifying dietary mistakes and then making recommendations to patients within that scope could help avoid a severe COVID-19 infection and speed up recovery. An anonymous online survey was conducted to study the dietary behavior and physical activity levels of COVID-19 sufferers between April and August 2022. The research tool comprised a specially devised and structured questionnaire and the FFQ-D10 food frequency questionnaire. A total of 159 people completed the questionnaire. Out of that number, 153 women over 18 years of age who were in home isolation due to COVID-19 were included in the study. The results show that 1.133 portions of cereal products were consumed daily, with unrefined groats and wholemeal or 'brown' bread with seeds being more common. Vegetable consumption stood at 2.225 portions per day, and fresh fruit at 1.774 portions per day. For sweets, consumption was 0.511 portions per day. Products that the study participants were least likely to consume were sweetened drinks, red meat, conventionally sweetened sweet fruit preserves, dried fruit and sweetened dairy drinks. Analysis of the anthropometric characteristics and dietary behaviour of women who participated in the study allowed for the preparation of dietary recommendations for COVID-19 patients.
DETERMINATION OF RESIDUAL SOLVENTS IN PSMA 11 - AN ACTIVE PHARMACEUTICAL SUBSTANCE IN PSMA-11 KIT FOR Ga-68 LABELLING
Authors: Lipka Robert , Kokoszka Agnieszka , Sawicka Agnieszka
Published: July 2023

A selective, sensitive and low sample consumption GC method for determination of residual solvents in PSMA samples was developed. Selectivity with respect to solvents such as ethanol, diethyl ether, 2-propanole, acetonitrile, dichloromethane, used in manufacturing of PSMA-11, was obtained on two different GC systems and columns. In all these cases, good separation and other system suitability parameters were obtained. The values of detection limit (LOD) and limit of quantitation (LOQ) were estimated and verified experimentally for ethanol, diethyl ether, 2-propanol (IPA), acetonitrile (ACN) and dichloromethane. Full validation parameters i.e.: selectivity, limit of detection (LOD), limit of quantitation (LOQ), linearity, precision, accuracy, robustness and system suitability parameters are presented with respect to ACN and IPA. Accuracy and precision were measured on two GC systems. Statistical tests exhibit, that there are no significant differences in accuracy and precision between two GC systems
Honokiol and magnolol - comparison of inhibitory activity of enzymes involved in carbohydrate and lipid metabolism and antioxidant properties in in vitro studies
Authors: Szałabska-Rąpała Katarzyna , Borymska Weronika , Zych Maria , Kaczmarczyk-Żebrowska Ilona
Published: July 2023

Oxidative stress is the basis of the pathogenesis of diabetes, obesity and their complications. Under its influence, free radicals that have not been neutralized or removed from the cell environment lead to damage to cellular macromolecules - carbohydrates, lipids and proteins. Honokiol and magnolol are neolignans derived from magnolia bark, which may be promising candidates in the fight against oxidative stress-related diseases. The aim of this study was to evaluate the antioxidant potential of structural isomers - honokiol and magnolol - in vitro, taking into account their effect on radicals and the potential possibility of protecting biomolecules against oxidative damage, as well as to analyze their capability to inhibit the activity of enzymes associated with carbohydrate and lipid metabolism. The abilities of neolignans to neutralize ABTS and DPPH radicals and also to prevent the formation of markers of oxidative damage - advanced oxidation protein products and thiobarbituric acid reactive substances were tested. The inhibitory properties of the compounds against the activity of enzymes (α-amylase, α-glucosidase, lipase) were also examined. The conducted analyzes indicate that in vitro honokiol possesses much better antioxidant properties and inhibits enzymes related to carbohydrate metabolism than magnolol. It neutralized model radicals and prevented oxidative damages almost as effectively as the reference compounds, with even better ability to inhibit enzymes involved in carbohydrate metabolism. None of the neolignans significantlly affected the reduction of lipase activity. The effectiveness of honokiol and magnolol as free radical scavengers and α-glucosidase and α-amylase inhibitors requires further confirmation in in vivo models.
Dispensing metformin with other drugs and dietary supplements in pharmaceutical care in patients with multimorbidity
Authors: Żyrek Luiza Anna , Bułaś Lucyna , Latocha Małgorzata
Published: July 2023

Pharmaceutical care is an activity aimed at protecting the patient’s health. The purpose of this benefit is to provide assistance in receiving and safely using the drug. The idea of pharmaceutical care originated in the United States in the 70s’ of the 20th century although the issue had already been discussed in the interwar period. The definition in force in Poland is contained in the Act on the Profession of Pharmacist (Act of September 10, 2020). The program includes pharmaceutical consultations, performing medications reviews, developing pharmaceutical care plans considering the patient’s drug-related problems, performing diagnostic tests and issuing prescriptions that are a continuation of a medical order(1).
This paper reviews the current literature on the use of metformin in patients with multimorbidity. Special attention was given to the studies on probability of occurrence potential drug-related problems in the treatment of these diseases. The analysis shows that the most difficulties are caused by the lack of knowledge about the treatment used by patients. The result is often a reduction in the regularity of therapy or even resignation from it. The obtained observations related to the combined use of drugs from different therapeutic groups should help to systematize knowledge about the current needs and expectations of patients. Properly conducted pharmaceutical care, including the preparation of drug reviews and education, can significantly improve the effectiveness of treatment. The article emphasizes the importance of the cooperation of the patient, doctor and pharmacist in achieving and maintaining the proper quality of life of the patient.
Penyuluhan pentingnya fase pra-analitik di bidang Patologi Anatomi di Kota Prabumulih
Authors: Murti Krisna , Ramkita Nora
Published: July 2023

Prosedur pembuatan preparat di Laboratorium Patologi Anatomi terdiri dari tiga tahap, diantaranya proses pra- analitik. Dampak dari kesalahan proses pra-analitik dapat menyebabkan kesalahan diagnosis dan pengobatan. Pengabdian masyarakat ini berlokasi di RS AR Bunda Kota Prabumulih, pada Sabtu, 15 Oktober 2022 berupa seminar edukasi, diskusi dan hands-on workshop untuk mempraktekkan prosedur fiksasi serta lamellation jaringan yang benar. Kegiatan diselenggarakan bersamaan dengan Dies Natalis ke-60 Fakultas Kedokteran Universitas Sriwijaya dan Pemerintah Kota Prabumulih. Para peserta seminar cukup aktif untuk bertanya dan berdiskusi. Peserta berjumlah 51 orang, berasal dari 4 rumah sakit, yaitu Rumah Sakit Prabumulih (31.4%), Rumah Sakit AR Bunda (31.4%), RS Pertamina Prabumulih (19.6%), RS Fadillah Prabumulih (9.8%), dan dari institusi lain sekitar 7.8%, terdiri dari perawat ruangan, dokter umum, perawat gigi, perawat ruang operasi, farmasi, dan laboran. Didapatkan peningkatan pengetahuan peserta sebesar 15% berdasarkan hasil pre-test dan post-test, sehingga diharapkan proses pengolahan jaringan di Laboratorium Patologi Anatomik dapat menghasilkan blok parafin dengan kualitas baik, pemeriksaan imunohistokimia menjadi akurat, dan diagnosis jaringan pasien menjadi lebih tepat.
Skrining kognitif pada dewasa dan lansia di Kelurahan Gunung Ibul Kota Prabumulih
Authors: Nindela Rini , Yusril Yusril , Marisdina Selly , Junaidi Achmad , Okparasta Andika , Anggraeni Dya
Published: July 2023

Kemajuan pembangunan di berbagai bidang, termasuk kesehatan, berimbas pada peningkatan usia harapan hidup masyarakat dan peningkatan populasi lanjut usia (lansia) di Indonesia. Pertambahan jumlah lansia mengakibatkan prevalensi penyakit tidak menular (PTM), termasuk demensia, ikut meningkat. Demensia menurunkan kemandirian penderitanya, hingga akhirnya menjadi beban bagi keluarga dan negara baik dari sisi ekonomi maupun psikososial. Dengan deteksi dini, penderita demensia bisa memperoleh pengobatan lebih awal sehingga progresivitas penyakit dapat dihambat. Telah dilaksanakan kegiatan pengabdian masyarakat berupa skrining fungsi kognitif dengan pemeriksaan Montreal Cognitive Assessment versi Indonesia (MoCA-Ina), yang dilanjutkan dengan penyuluhan dan pembagian pamflet tentang demensia, di Kelurahan Gunung Ibul Kota Prabumulih provinsi Sumatera Selatan. Peserta kegiatan berjumlah 40 orang, terdiri dari 5 (12,5%) orang laki-laki dan 35 (87,5%) orang perempuan dengan rerata usia 60,68±9,22 tahun. Pada kegiatan ini didapatkan masyarakat usia dewasa dan lansia dengan fungsi kognitif yang menurun (skor MoCA-Ina kurang dari 26) sebanyak 29 orang (72,5%). Ranah kognitif yang paling banyak mengalami penurunan adalah memori dan visuospasial/eksekutif. Deteksi dini demensia perlu dilakukan secara berkala terutama pada populasi berisiko. Kegiatan edukasi demensia juga perlu digiatkan untuk meningkatkan kesadaran masyarakat tentang demensia.
Nesszosz vére – az orosz–nyugati szankciós játszma és következményei
Authors: Deák András György , Klauda Zalán
Published: July 2023

A cikk a 2022. februári háborúindítás óta kibontakozott orosz–nyugati szankciós játszma korai elemzését adja. A szakirodalom elemzési konvencióinak megfelelően áttekinti annak előzményeit, a kiinduló pozíciókat, a megfogalmazott célrendszert, az annak elérése érdekében alkalmazott eszközöket, az adaptáció gazdasági és politikai aspektusait. Ezen túlmenően az elméleti irodalomra támaszkodva szempontokat kínál az eredményesség értékeléséhez, illetve kitekintést ad a magyar vonatkozásokra is. Az orosz–nyugati szankciós játszma a nemzetközi politika és világgazdaság egyik meghatározó kérdésköre, annak sorsa vízválasztó lehet a gazdasági nyomásgyakorlás jövendő megítélését, elfogadottságát és alkalmazhatóságát illetően.
Rib Osteoblastoma: A Rare Benign Primary Bone Tumor - Clinical Case Report
Authors: Cuauro Juan C Araujo
Published: July 2023

Objective: To present a clinical case of a rare pathology, to know its aggressive behavior, its limited ability to metastasize, and its therapeutic management, as well as to review the current literature. Clinical Case: A 22-year-old male patient, with no personal or family history of the disease, was found to have a radiating mass at the left posterior 10th rib arch, with a rounded appearance, low-density areas inside, rounded, and well-defined microspheres at the margin, measuring 4.3 cm × 4.3 cm. The surgery was performed through a left posterolateral thoracotomy, which removed nearly two-thirds of the 10th posterior arch of the left rib and with its costal-vertebral disarticulation. Anatomic and pathological studies reported a histological diagnosis of rib osteoblastoma or giant cell bone tumor. Conclusion: This is uncommon and difficult to predict bone tumor in behavior, as almost all bone tumors contain giant cells. It is a primary bone tumor with benign features that invades the local area in an aggressive manner, with a biphasic component of giant cells and a highly vascularized spindle cell component. It often relapses and has limited metastatic ability. Osteoblastoma or giant cell tumor of the bone is a rare tumor located in the ribs, making it even more unusual. However, its prognosis is good, although it can recur and metastasize.
Observações sobre o Desenvolvimento de Fibrossarcoma Transplantado em Gerbil (Meriones Unguiculatus)
Authors: Pereira Maria Vanessa Lott , Rossi Maria Isabel Doria , Guzmán-Silva Maria Angélica
Published: July 2023

O trabalho apresenta os resultados da observação do comportamento de um fibrossarcoma quimicamente induzido e transplantado em gerbil, no que diz respeito a suas características de crescimento, incidência, período de latência e reação do hospedeiro. A inoculação subcutanea de células tumorais em suspensão obtidas de animais portadores de fibrossarcoma intraperitoneal e tratados ou não com óleo mineral, grupo A e B, respectivamente, deu origem, com alta freqüência nos dois grupos, a tumores com características semelhantes ao tumor primitivo. Porém o tempo de latência foi significativamente menor no grupo A. O ritmo de crescimento do tumor foi similar entre os grupos e a análise de todos os dados retratou uma curva inicialmente exponencial, tendendo a convexa no decorrer do tempo, o que foi também demonstrado por um crescente tempo de duplicação da área tumoral. Durante o período experimental os animais portadores de fibrossarcoma apresentaram perda de peso corporal livre do tumor, sendo este fato interpretado como uma manifestação inicial de caquexia, associada à progressão das neoplasias. O peso dos tumores no dia do sacrifício apresentou correlação significativa com a área tumoral e permitiu a elaboração de uma reta de regressão linear, que pode ser usada para inferir o peso de tumores do mesmo tipo a partir de medidas externas da área.
Catalasemia em tumor de Wilms
Authors: Kato Mara Albonei D. P. , Cassilha Amadeu , Abrão Dionísio , Tanaka Elio , Mortean Carlos Roberto , Ramos Jesusmar H. , Militão Luiz , Nascimento Aguinaldo José do , Nascimento Kazuko Hishida do , Pilotto Rui Fernando
Published: July 2023

A associação de deficiência de catalase com neoplasias tem sido estudada nos últimos anos, sendo particularmente notável na presença de tumor de Wilms, forma hereditária, e aniridia. Pouco se comenta sobre seu comportamento nas formas esporádicas desse tumor. Em 1984, Turleau e cois. descreveram o primeiro caso de tumor de Wilms e deficiência de catalase, sem aniridia. No presente estudo avaliamos a catalasemia em 13 pacientes com tumor de Wilms e comparamos seus níveis com os de 22 crianças do grupo-controle normal e 10 determinações de um grupo-controle em quimioterapia. Os resultados mostram que a catalasemia foi mais elevada no grupo de pacientes com tumor de Wilms do que no controle normal e mais elevada ainda naqueles que já haviam concluído o tratamento quimioterápico proposto. O grupo-controle em quimioterapia também apresentou níveis elevados de catalasemia, fazendo supor que essa atividade enzimática sofre influência da ação dos quimioterápicos ou, ainda, que ela está associada a uma situação de homeostase do hospedeiro.
Aspectos dos quadros clínico, citológico e da microbiota fúngica da mucosa bucal de pacientes com carcinoma da boca, antes e durante a radioterapia
Authors: Sampaio Maria Carmeli C. , Birman Esther G. , Paula Claudete R.
Published: July 2023

Os autores estudaram clinicamente as lesões e alterações observadas na mucosa bucal de pacientes com carcinoma da boca, independente da neoplasia presente, antes e durante o tratamento radioterápico, por meio da citologia esfoliativa (Papanicolaou e PAS) e esfregaços corados pelo Gram. Comprovou-se um aumento de leveduras durante o tratamento, predominando as formas filamentosas, consideradas mais patogênicas. Podem-se detectar áreas bem definidas de candidose, quer do tipo atrófica ou pseudomembranosa, além de áreas de radiomucosite, embora a associação de lesões brancas e eritematosas predominassem levando a um mascaramento do quadro clínico presente. Aumento significativo de sintomas desde ardor a xerostomia, entre outros, foi observado durante o tratamento.
The prevention of political corruption and implementation of the Political Party Integrity System in Partai Kebangkitan Bangsa
Authors: Perdana Aditya , Hanifuddin Muhammad
Published: July 2023

This paper focuses on examining the institutionalization of the Political Party Integrity System (SIPP) which was pushed by the Corruption Eradication Commission (KPK) as part of efforts to prevent political corruption in the National Awakening Party (PKB). Since the 2009, 2014 and 2019 elections, PKB's vote share has increased. The number of party cadres who were caught in corruption cases was relatively small compared to other parties. The main question to be answered is how the institutionalization of SIPP in PKB was initiated by the KPK as part of efforts to prevent political corruption? The theoretical framework used is O'Donnell's institutionalization theory. There are two stages of institutionalization; the spread of values (value infusion) and routine actions against these values (behavioral routineization). Data was collected through literature review and interviews. This research shows that the institutionalization of SIPP in PKB takes place through the stage of spreading SIPP values. This distribution is contained in Mabda' Siyasi, AD/ART, PKB Manifesto, and Party Regulations. It regulates the code of ethics, regeneration and recruitment, internal democratization, and financial governance. The next stage is getting used to the internal provisions of this PKB in carrying out party activities. PKB is one of the parties that welcomes the existence of SIPP. For PKB, SIPP is an acceleration to strengthen party integrity. Become a concrete step to prevent political corruption involving party cadres.
Anti-corruption system 4.0: The adoption of blockchain technology in the public sector
Authors: Azmi Ilima Fitri , Nugroho Alih Aji
Published: July 2023

Countries are using various sophisticated information technologies to help provide quality and transparent services. This research aims to explore the potential and models of using blockchain technology to overcome corruption problems in Indonesia. Proper utilisation of blockchain technology can increase accountability and reduce loopholes in corrupt practices. Blockchain is a distributed database with records (ledgers) shared by all network participants. Smart contract as a form of blockchain can help make the process more transparent and trackable. Since blockchain is a relatively new technology, very few studies have been done to explain its potential in the public sector, particularly with regards to issues of corruption. This study develops a model for the application of blockchain technology and conducts an in-depth analysis of its possibilities using a qualitative method and an exploratory approach. In-depth interviews, designed to get a big picture view of the blockchain development model in the public sector were conducted with several sources, namely the Director General of Asset Tracing KPK (Indonesian Anti-Corruption Commission), KPK Public Prosecutors, the KPK IT department, WIr Group, Financial and Development Oversight Agency (BPKP), and blockchain practitioners. The research was conducted between August and December 2022. The study's findings demonstrate how promising it is to use blockchain technology to lessen corruption. Distributed ledgers give governments new ways to improve transparency. The model that can be applied is ‘permissioned blockchain’ because it has a private nature. Blockchain application requires top management support, organisational readiness, and organisational support. To deepen understanding, further experimental research is needed to test the model.
Inovasi kebijakan kepala daerah dari jalur perseorangan
Authors: Kabullah Muhammad Ichsan , Koeswara Hendri , Yulivestra Malse , Apriwan Apriwan , Nabilla Nabilla , Irkha Fathoni Nugrah
Published: July 2023

Artikel ini berangkat dari fenomena pasangan calon kepala daerah yang maju dan menang melalui jalur perseorangan dalam Pilkada. Kehadiran kepala daerah perseorangan perlu diuji khususnya dalam membangun pemerintahan yang bebas korupsi. Penulis mengambil kasus rekrutmen pejabat eselon pemerintah daerah mengingat disektor tersebut sangat rentan korupsi. Penelitian dilakukan di dua daerah yang pernah dan sedang dijabat kepala daerah dari jalur perseorangan yakni Kota Bukittinggi, Provinsi Sumatera Barat dan Kabupaten Tanjung Jabung Timur, Provinsi Jambi. Metode penelitian yang akan diguna-kan adalah kualitatif dengan teknik pengambilan data berupa wawancara mendalam kebanyak pihak, studi kepustakaan, observasi, dan dokumentasi. Dari hasil penelitian, praktik jual-beli jabatan yang acapkali terjadi pada banyak daerah, justru tidak ditemukan dikedua daerah. Kepala daerah dari jalur perseorangan berhasil melakukan inovasi kebijakan dengan tidak banyak mengintervensi dan menyerahkan sepenuhnya mekanisme proses rekrutmen pejabat eselon sesuai aturan. Jikapun perubahan dilakukan, sifatnya tidak frontal dan selalu mengedepankan prinsip meritokrasi. Hal ini dengan sendirinya memunculkan stabilitas dalam penyelenggaraan pemerintahan. Untuk itu, eksistensi kepala daerah perseorangan terbukti linear dengan agenda pencegahan korupsi. Meskipun demikian, kepala daerah dari jalur perseorangan tetap memerlukan penguatan seperti dukungan pendanaan negara dalam Pilkada, afirmasi persyaratan, dan pengaturan yang lebih inklusif.
Estudo bioclimatológico de aves poedeiras no sudeste do Pará
Authors: Oliveira Raytane Chaves , Moura Jose Helder
Published: July 2023

O objetivo do trabalho foi avaliar a influência do clima no bem-estar de aves poedeiras. O período experimental teve duração de trinta dias, durantes os meses de abril e maio de 2017. A área de estudo foi em sistema semi-pastoril para 200 aves poedeiras coloniais, (galinha Embrapa 051) de 21 a 25 semanas de vida. Envolve o acompanhamento de variáveis climáticas que possam afetar o bem-estar animal, mensurações do ambiente externo: temperatura bulbo seco, e bulbo úmido, com intervalo de 2 horas; temperatura máximo, mínima. Das mensurações fisiológicas que foram observadas: frequência respiratória temperatura cloacal; temperatura de superfície de cabeça; dorso e pata; e frequência cardíaca. Apresentados os resultados das mensurações fisiológicas que foram submetidos ao teste de tukey, maiores índices de temperatura cloacal foram de 41.71 a2 a3 e 41.95 a3, devido ao acúmulo de calor durante todo o dia, estando acima limite inferior da condição de estresse térmico. Tendo os maiores coeficientes de variações foram encontrados na frequência cardíaca com 12.31% e frequência respiratória 45.26%. As variáveis ambientais e os índices de conforto mostraram que as aves se mantiveram em condições mínimas de conforto térmico, não comprometendo dessa forma a saúde do animal ou a produção dos mesmos.