bluuebunny/crossref_metadata_2025 huggingface dataset:
Rolling bearing fault feature extraction using Adaptive Resonance-based Sparse Signal Decomposition
Authors: Wang Kaibo , Jiang Hongkai , Wu Zhenghong , Cao Jiping
Published: August 2020

The existence of periodic impacts in collected vibration signal is the representative symptom of rolling bearing localized defect. Due to the complicacy of the working condition, the fault-related impacts are usually submerged in other ingredients. This article proposes an adaptive Resonance-based Sparse Signal Decomposition (RSSD) for extracting the fault features of rolling bearings. Adaptive RSSD is constructed to fetch the impacts from collected vibration signal, by making RSSD decomposed signal kurtosis value maximum using Lion Swarm Algorithm (LSA). Multipoint Optimal Minimum Entropy Deconvolution Adjusted (MOMEDA) is further performed to enhance the amplitude and periodicity of impacts contained in RSSD decomposed signal, so that fault feature is highlighted. The superiority and availability of proposed strategy are validated by applying to single fault feature extraction of an experimental dataset and compound faults feature extraction of a locomotive rolling bearing.
Effect of Elevated Ambient Temperature on Simulator-Derived Oscillometric Blood Pressure Measurement
Authors: Ringrose Jennifer S , Kennedy Michael D , Kassam Jalisa , Mouhammed Omar , Sridar Sangita , Kenwell Zoltan , Padwal Raj
Published: August 2020

BACKGROUND

Oscillometric blood pressure (BP) devices are typically labeled for use up to 40 °C. Many geographic regions have ambient temperatures exceeding 40 °C. We assessed the effect of increased ambient temperature (40–55 °C) on simulator-derived oscillometric BP measurement.

METHODS

Three Omron BP769CAN devices, 3 A&D Medical UA-651BLE devices, and accompanying cuffs were used. A custom heat chamber heated each device to the specified temperature. A noninvasive BP simulator was used to take 3 measurements with each device at differing temperatures (22, 40, 45, 50, and 55 °C) and BP thresholds: 80/50, 100/60, 120/80, 140/90, 160/110, and 180/130 mm Hg. Using each device as its own control (22 °C), we determined the relative differences in mean BP for each device at each temperature and BP setting, assessed graphical trends with increasing temperature, and examined variability.

RESULTS

Graphical trends of mean simulator-subtracted BP differences from room temperature showed no discernable pattern, with differences clustered around zero. Overall mean difference in BP (combined elevated temperatures minus room temperature) was −0.8 ± 2.1 (systolic ± SD)/1.2 ± 3.5 (diastolic ± SD) mm Hg for the A&D device and 0.2 ± 0.4 (systolic ± SD)/−0.1 ± 0.1 (diastolic ± SD) mm Hg for the Omron. All individual elevated temperature differences (elevated temperature minus room temperature) except A&D diastolic BP at 50 °C were within 5 mm Hg.

CONCLUSIONS

In this simulator-based study assessing within-device differences, higher ambient temperatures resulted in oscillometric BP measurements that were comparable to those performed at room temperature.
Compete or commit: Preferences for early commitment process or ASHP Match among pharmacy residency program directors and residents
Authors: Cleverdon Kristin , Fisher Amber K , Mason Barbara , Nguyen Elaine
Published: August 2020

Purpose

To assess the recruitment preferences of directors of postgraduate year 2 (PGY2) pharmacy residency programs and postgraduate year 1 (PGY1) pharmacy residents seeking PGY2 residency positions, as well as key drivers of preference.

Methods

Two Web-based questionnaires were administered to residency program directors (RPDs) of PGY2 programs and PGY1 residents, respectively. Participants were recruited via email, and responses were collected from November 27 through December 14, 2018. RPDs and PGY1 residents were surveyed about their preferences regarding participation in the ASHP Resident Matching Program (ASHP Match) and participation in the early commitment process (ECP). Respondents were also asked to rank the importance of prespecified factors in decisions about whether to participate in either the Match or the ECP.

Results

The RPD questionnaire was completed by 295 participants in 43 states. The majority of RPDs (70.2%) stated that their PGY2 program generally preferred the ECP to the ASHP Match. Regardless of program preference, the most important driver of preference was the current PGY1 resident’s personality and fit. There were 243 completed resident questionnaires from 41 states. The majority of respondents (83.5%) indicated a preference to participate in the ECP vs the ASHP Match. Of those preferring the ECP, the highest-ranked consideration was the opportunity for further development at their PGY1 site.

Conclusion

Overall, the survey results indicated that both PGY2 programs and PGY1 residents interested in PGY2 training generally prefer the ECP to the ASHP Match. The survey results should be considered by stakeholders (students, residents, and RPDs) in deciding whether to participate in the Match or the ECP process.
Immediate Post-concussion and Cognitive Testing: Ceiling Effects, Reliability, and Implications for Interpretation
Authors: Gaudet Charles E , Konin Jeff , Faust David
Published: August 2020

Objective

The most commonly used computerized neurocognitive test in concussion assessment and management, Immediate Post-concussion and Cognitive Testing (ImPACT), has demonstrated varying and sometimes concerning levels of test–retest reliability. This study aimed to further examine ImPACT’s psychometric qualities and whether ceiling effects may suppress its reliability.

Method

A total of 300 consecutively selected ImPACT score reports for students attending a secondary school between 2010 and 2015 were reviewed. Test–retest reliabilities for composite scores and subscales were computed using Pearson product moment correlations (r) and intraclass correlation coefficients. To examine the potential influence of ceiling effects, we conducted frequency analyses of scores falling at, or near, the maximum possible score.

Results

A total of 92 score reports met inclusion criteria. Test–retest reliabilities ranged from 0.42 to 0.69 for composite scores and 0.19 to 0.71 for subscales. Subscales comprising the Verbal and Visual Memory composites evidenced the most prominent ceiling effects.

Conclusions

Obtained test–retest reliabilities were consistent with a large segment of the literature and add to concerns about ImPACT’s reliability. Furthermore, at least in a select sample, this study identified sizeable ceiling effects that likely diminish the reliability of some composite scores. To mitigate the risk of false-negative errors on post-injury testing, ImPACT users should be cognizant of such ceiling effects. Supplemental, or alternative, approaches to protect against underestimating baseline functioning also warrant consideration.
Topoly: Python package to analyze topology of polymers
Authors: Dabrowski-Tumanski Pawel , Rubach Pawel , Niemyska Wanda , Gren Bartosz Ambrozy , Sulkowska Joanna Ida
Published: August 2020

The increasing role of topology in (bio)physical properties of matter creates a need for an efficient method of detecting the topology of a (bio)polymer. However, the existing tools allow one to classify only the simplest knots and cannot be used in automated sample analysis. To answer this need, we created the Topoly Python package. This package enables the distinguishing of knots, slipknots, links and spatial graphs through the calculation of different topological polynomial invariants. It also enables one to create the minimal spanning surface on a given loop, e.g. to detect a lasso motif or to generate random closed polymers. It is capable of reading various file formats, including PDB. The extensive documentation along with test cases and the simplicity of the Python programming language make it a very simple to use yet powerful tool, suitable even for inexperienced users. Topoly can be obtained from https://topoly.cent.uw.edu.pl.
Structure of the reproductive system of the sexual generation of the endemic Arctic species Acyrthosiphon svalbardicum and its temperate counterpart Acyrthosiphon pisum (Hemiptera, Aphididae)
Authors: Wieczorek Karina , Chłond Dominik , Junkiert Łukasz , Świątek Piotr
Published: August 2020

The Arctic aphids live briefly and must breed quickly to survive. Shortened life cycle, with only two generations: the stem mother and sexuales—oviparous females and males is an adaptation for optimal use of the short breeding period, which lasts from late July to the end of August. Using Acyrthosiphon svalbardicum, an endemic High Arctic aphid species, we describe the structure of the reproductive system of sexual morphs and compare with its temperate counterparts, in particular the model organism the pea aphid Acyrthosiphon pisum. Generally, the histological composition and ultrastructure of reproductive system of sexuales of A. svalbardicum is broadly similar to the reproductive systems described already in other species of aphids. The unique characters include in both oviparous females and males an enormous layer of the fat body, adhering to the structures of the internal reproductive system. The greatly enlarged accessory glands of males accumulate a heterogenous secretion composed of irregularly organized bunches of spicule-like structures of high electron density embedded in fine and coarse granular material. This material, unknown among temperate counterparts of A. svalbardicum, during mating is transported from the accessory glands of the male to its ejaculatory duct, where it is mixed with the ejaculate, and then is transferred to the spermatheca of the oviparous female.
Transcriptomic response to elevated water temperatures in adult migrating Yukon River Chinook salmon (Oncorhynchus tshawytscha)
Authors: Bowen Lizabeth , von Biela Vanessa R , McCormick Stephen D , Regish Amy M , Waters Shannon C , Durbin-Johnson Blythe , Britton Monica , Settles Matthew L , Donnelly Daniel S , Laske Sarah M , Carey Michael P , Brown Randy J , Zimmerman Christian E
Published: August 2020

Chinook salmon (Oncorhynchus tshawytscha) declines are widespread and may be attributed, at least in part, to warming river temperatures. Water temperatures in the Yukon River and tributaries often exceed 18°C, a threshold commonly associated with heat stress and elevated mortality in Pacific salmon. Untangling the complex web of direct and indirect physiological effects of heat stress on salmon is difficult in a natural setting with innumerable system challenges but is necessary to increase our understanding of both lethal and sublethal impacts of heat stress on populations. The goal of this study was to characterize the cellular stress response in multiple Chinook salmon tissues after acute elevated temperature challenges. We conducted a controlled 4-hour temperature exposure (control, 18°C and 21°C) experiment on the bank of the Yukon River followed by gene expression (GE) profiling using a 3′-Tag-RNA-Seq protocol. The full transcriptome was analysed for 22 Chinook salmon in muscle, gill and liver tissue. Both the 21°C and 18°C treatments induced greater activity in genes associated with protein folding (e.g. HSP70, HSP90 mRNA) processes in all tissues. Global GE patterns indicate that transcriptomic responses to heat stress were highly tissue-specific, underscoring the importance of analyzing multiple tissues for determination of physiological effect. Primary superclusters (i.e. groupings of loosely related terms) of altered biological processes were identified in each tissue type, including regulation of DNA damage response (gill), regulation by host of viral transcription (liver) and regulation of the force of heart contraction (muscle) in the 21°C treatment. This study provides insight into mechanisms potentially affecting adult Chinook salmon as they encounter warm water during their spawning migration in the Yukon River and suggests that both basic and more specialized cellular functions may be disrupted.
Ten Reasons to Think About Bile Acids in Managing Inflammatory Bowel Disease
Authors: Camilleri Michael
Published: August 2020

Abstract

There are ten good reasons why it is important to think about abnormalities in bile acid control in inflammatory bowel disease. Before reviewing these reasons, it is relevant to review essential elements in the enterohepatic circulation, synthesis and actions of bile acids.
Case report: third-degree atrioventricular block secondary to septic coronary artery embolism following infective endocarditis
Authors: Prashar Abhisheik , Chen Daniel , Youssef George , Ramsay David
Published: August 2020

Background

Coronary artery emboli can occur from a number of rare causes such as arterial thrombo-embolus or septic embolus. This diagnosis generally requires multi-modal imaging including echocardiography, computed tomography, or invasive coronary angiography. Septic coronary emboli is an extremely rare consequence of infective endocarditis (IE), having been reported in <1% of all cases.

Case summary

A 54-year-old previously healthy Tibetan monk presented feeling generally unwell and lethargic. Electrocardiogram demonstrated sinus rhythm, third-degree atrioventricular block with a left bundle branch escape. Initial transthoracic and transoesophageal echocardiography demonstrated vegetations on the aortic and tricuspid valve as well as intra-myocardial abscess. Coronary angiography revealed septic embolus involving the septal perforator coronary artery. He underwent surgical replacement of the infected valves and debridement and repair of a ventricular septal defect.

Discussion

Infective endocarditis can predispose to a range of cardiac pathology. This case demonstrates that patients can present with cardiac conduction disease from a septic embolus involving a coronary artery as a complication of IE.
The Effect of Fertility on Mothers’ Labor Supply over the Last Two Centuries
Authors: Aaronson Daniel , Dehejia Rajeev , Jordan Andrew , Pop-Eleches Cristian , Samii Cyrus , Schulze Karl
Published: August 2020

Using a compiled data set of 441 censuses and surveys from between 1787 and 2015, representing 103 countries and 51.4 million mothers, we find that: (i) the effect of fertility on labour supply is typically indistinguishable from zero at low levels of development and large and negative at higher levels of development, (ii) the negative gradient is stable across historical and contemporary data, and (iii) the results are robust to identification strategies, model specification, and data construction and scaling. Our results are consistent with changes in the sectoral and occupational structure of female jobs and a standard labour–leisure model.
Burden of family caregivers of Down syndrome children: a cross-sectional study
Authors: Alam El-Deen Nadia , Alwakeel Angi A , El-Gilany Abdel-Hady , Wahba Yahya
Published: August 2020

Background

Down syndrome (DS) is the most common chromosomal abnormality encountered by primary care physicians. The demands of families with DS children are significantly high with possible burdens on their primary caregivers.

Objective

To assess the burden of DS children on their family primary caregivers and to identify the variables associated with caregiver burden.

Methods

A cross-sectional study was conducted in Mansoura, Egypt from March 2019 to March 2020 including 457 family primary caregivers and their DS children. Socio-demographic and clinical data were collected through direct interviews. Caregiver burden was assessed by Zarit Burden Interview (ZBI-22) scale. The associations between categorical variables were tested using chi-square test, crude odds ratio and 95% confidence interval. Logistic regression analysis was carried out to detect the variables independently associated with caregiver burden.

Results

More than half (51.9%) of caregivers had no or little burden, 40.7% had mild to moderate burden and 7.4% had moderate to severe burden. Female caregiving, single parent status and DS children of age less than 6 years old, female gender and having congenital heart diseases were the variables independently associated with mild to severe burden with adjusted odds ratios of 4.2, 2.5, 1.5, 2.1 and 1.7, respectively.

Conclusions

Less than half of family primary caregivers of DS children in Mansoura, Egypt suffered from mild to severe burden. Primary care physicians could recognize caregivers at risk of burden using ZBI-22 scale, and provide appropriate social, medical and psychological care for parents and DS children to mitigate this burden.
Response of a methane-driven interaction network to stressor intensification
Authors: Ho Adrian , Mendes Lucas W , Lee Hyo Jung , Kaupper Thomas , Mo Yongliang , Poehlein Anja , Bodelier Paul L E , Jia Zhongjun , Horn Marcus A
Published: August 2020

Microorganisms may reciprocally select for specific interacting partners, forming a network with interdependent relationships. The methanotrophic interaction network, comprising methanotrophs and non-methanotrophs, is thought to modulate methane oxidation and give rise to emergent properties beneficial for the methanotrophs. Therefore, microbial interaction may become relevant for community functioning under stress. However, empirical validation of the role and stressor-induced response of the interaction network remains scarce. Here, we determined the response of a complex methane-driven interaction network to a stepwise increase in NH4Cl-induced stress (0.5–4.75 g L−1, in 0.25–0.5 g L−1 increments) using enrichment of a naturally occurring complex community derived from a paddy soil in laboratory-scale incubations. Although ammonium and intermediates of ammonium oxidation are known to inhibit methane oxidation, methanotrophic activity was unexpectedly detected even in incubations with high ammonium levels, albeit rates were significantly reduced. Sequencing analysis of the 16S rRNA and pmoA genes consistently revealed divergent communities in the reference and stressed incubations. The 16S rRNA-based co-occurrence network analysis revealed that NH4Cl-induced stress intensification resulted in a less complex and modular network, likely driven by less stable interaction. Interestingly, the non-methanotrophs formed the key nodes, and appear to be relevant members of the community. Overall, stressor intensification unravels the interaction network, with adverse consequences for community functioning.
Redo pull-through in total colonic aganglionosis due to residual aganglionosis: a single center’s experience
Authors: Yan Jia-Yu , Peng Chun-Hui , Pang Wen-Bo , Chen Yong-Wei , Ding Cai-Ling , Chen Ya-Jun
Published: August 2020

Background

Reoperation for total colonic aganglionosis (TCA) may be required for residual aganglionosis after an initial radical operation. We aimed to investigate the symptoms, management, and outcomes of patients who required a redo pull-through (Redo PT).

Methods

Nine TCA patients underwent Redo PT at our center between 2007 and 2017. Their medical records were reviewed. Parental telephone interviews that included disease-specific clinical outcomes were conducted, and post-operative complications and long-term outcomes (including height-for-age/weight-for-age and bowel-function score) were compared to those of single-pull-through (Single PT) patients (n = 21).

Results

All the nine Redo PT patients suffered obstruction within 1 month after the initial operation that could not be alleviated by conservative treatment. All abdominal X-ray/contrast barium enemas showed proximal bowel dilatation, indicating residual aganglionosis. The median ages at the initial operation and Redo PT were 200 and 509 days, respectively. Reoperation consisted of an intraoperative frozen biopsy and a modified laparotomic Soave procedure in all patients. Post-operative complications included perianal excoriation (n = 3), intestinal obstruction (n = 2), enterocolitis (n = 2), and rectovestibular fistula (n = 1). Seven Redo PT patients were followed up for a mean time of 7.1 ± 2.3 years; six (85.7%) had good growth and four (57.1%) had good bowel-function recovery. Post-operative complications and long-term outcomes were almost equal between the Redo PT and Single PT groups (all P > 0.05).

Conclusion

TCA patients with recurrent obstructive symptoms and dilated proximal bowel may have residual aganglionosis after an initial operation. Redo PT is effective and provides good long-term outcomes comparable to those of patients who benefited from Single PT.
Genomic Signatures of Honey Bee Association in an Acetic Acid Symbiont
Authors: Smith Eric A , Newton Irene L G
Published: August 2020

Recent declines in the health of the honey bee have startled researchers and lay people alike as honey bees are agriculture’s most important pollinator. Honey bees are important pollinators of many major crops and add billions of dollars annually to the US economy through their services. One factor that may influence colony health is the microbial community. Indeed, the honey bee worker digestive tract harbors a characteristic community of bee-specific microbes, and the composition of this community is known to impact honey bee health. However, the honey bee is a superorganism, a colony of eusocial insects with overlapping generations where nestmates cooperate, building a hive, gathering and storing food, and raising brood. In contrast to what is known regarding the honey bee worker gut microbiome, less is known of the microbes associated with developing brood, with food stores, and with the rest of the built hive environment. More recently, the microbe Bombella apis was identified as associated with nectar, with developing larvae, and with honey bee queens. This bacterium is related to flower-associated microbes such as Saccharibacter floricola and other species in the genus Saccharibacter, and initial phylogenetic analyses placed it as sister to these environmental bacteria. Here, we used comparative genomics of multiple honey bee-associated strains and the nectar-associated Saccharibacter to identify genomic changes that may be associated with the ecological transition to honey bee association. We identified several genomic differences in the honey bee-associated strains, including a complete CRISPR/Cas system. Many of the changes we note here are predicted to confer upon Bombella the ability to survive in royal jelly and defend themselves against mobile elements, including phages. Our results are a first step toward identifying potential function of this microbe in the honey bee superorganism.
A Lineage-Specific Paralog of Oma1 Evolved into a Gene Family from Which a Suppressor of Male Sterility-Inducing Mitochondria Emerged in Plants
Authors: Arakawa Takumi , Kagami Hiroyo , Katsuyama Takaya , Kitazaki Kazuyoshi , Kubo Tomohiko
Published: August 2020

Cytoplasmic male sterility (MS) in plants is caused by MS-inducing mitochondria, which have emerged frequently during plant evolution. Nuclear restorer-of-fertility (Rf)genes can suppress their cognate MS-inducing mitochondria. Whereas many Rfs encode a class of RNA-binding protein, the sugar beet (Caryophyllales) Rf encodes a protein resembling Oma1, which is involved in the quality control of mitochondria. In this study, we investigated the molecular evolution of Oma1 homologs in plants. We analyzed 37 plant genomes and concluded that a single copy is the ancestral state in Caryophyllales. Among the sugar beet Oma1 homologs, the orthologous copy is located in a syntenic region that is preserved in Arabidopsis thaliana. The sugar beet Rf is a complex locus consisting of a small Oma1 homolog family (RF-Oma1 family) unique to sugar beet. The gene arrangement in the vicinity of the locus is seen in some but not all Caryophyllalean plants and is absent from Ar. thaliana. This suggests a segmental duplication rather than a whole-genome duplication as the mechanism of RF-Oma1 evolution. Of thirty-seven positively selected codons in RF-Oma1, twenty-six of these sites are located in predicted transmembrane helices. Phylogenetic network analysis indicated that homologous recombination among the RF-Oma1 members played an important role to generate protein activity related to suppression. Together, our data illustrate how an evolutionarily young Rf has emerged from a lineage-specific paralog. Interestingly, several evolutionary features are shared with the RNA-binding protein type Rfs. Hence, the evolution of the sugar beet Rf is representative of Rf evolution in general.
Lithospheric structures of and tectonic implications for the central–east Tibetan plateau inferred from joint tomography of receiver functions and surface waves
Authors: Feng Mei , An Meijian , Mechie James , Zhao Wenjin , Xue Guangqi , Su Heping
Published: August 2020

We present an updated joint tomographic method to simultaneously invert receiver function waveforms and surface wave dispersions for a 3-D S-wave velocity (Vs) model. By applying this method to observations from ∼900 seismic stations and with a priori Moho constraints from previous studies, we construct a 3-D lithospheric S-wave velocity model and crustal-thickness map for the central–east Tibetan plateau. Data misfit/fitting shows that the inverted model can fit the receiver functions and surface wave dispersions reasonably well, and checkerboard tests show the model can retrieve major structural information. The results highlight several features. Within the plateau crustal thickness is >60 km and outwith the plateau it is ∼40 km. Obvious Moho offsets and lateral variations of crustal velocities exist beneath the eastern (Longmen Shan Fault), northern (central–east Kunlun Fault) and northeastern (east Kunlun Fault) boundaries of the plateau, but with decreasing intensity. Segmented high upper-mantle velocities have varied occurrences and depth extents from south/southwest to north/northeast in the plateau. A Z-shaped upper-mantle low-velocity channel, which was taken as Tibetan lithospheric mantle, reflecting deformable material lies along the northern and eastern periphery of the Tibetan plateau, seemingly separating two large high-velocity mantle areas that, respectively, correspond to the Indian and Asian lithospheres. Other small high-velocity mantle segments overlain by the Z-shaped channel are possibly remnants of cold microplates/slabs associated with subductions/collisions prior to the Indian–Eurasian collision during the accretion of the Tibetan region. By integrating the Vs structures with known tectonic information, we derive that the Indian slab generally underlies the plateau south of the Bangong–Nujiang suture in central Tibet and the Jinsha River suture in eastern Tibet and west of the Lanchangjiang suture in southeastern Tibet. The eastern, northern, northeastern and southeastern boundaries of the Tibetan plateau have undergone deformation with decreasing intensity. The weakly resisting northeast and southeast margins, bounded by a wider softer channel of uppermost mantle material, are two potential regions for plateau expansion in the future.
Defining ‘older people’ in Chile: challenges in planning policies for ageing populations
Authors: Villalobos Dintrans Pablo , Izquierdo Catalina , Guzmán René , Gálvez María José , Santander Sylvia
Published: August 2020

The concept of older adult is extensively used in day-to-day discussions and public policy. Nonetheless, concrete operational definitions are scarce. This poses a challenge for policymakers when designing initiatives targeted to this population. Chronological age has been traditionally used as the sole criteria for identifying older people (OP). However, there is no consensus about what is the age that should define an elderly. The issue became evident when, in 2018, the Chilean Ministry of Health started a planning process to coordinate health initiatives for OP. Two thresholds had been commonly used—60 and 65 years—and the differences between choosing one and the other were significant. This article intends to structure the debate around age thresholds and the definition of OP in Chile, presenting information and evidence to guide decision-makers when deciding about the issue. Information was based on international guidelines and definitions, laws and practice in the country and epidemiological data. The analysis shows a lack of consensus when dealing with the definition of OP using age thresholds at every level. Results highlight the difficulty of using age as a guide for designing policies for OP and call for a more holistic way for identifying OP as beneficiaries of targeted programmes, considering the heterogeneity of this population and the availability of information. This debate is much needed in many countries that, like Chile, will experience significant demographic changes and face the challenges of healthy ageing.
Mutual information for low-rank even-order symmetric tensor estimation
Authors: Luneau Clément , Barbier Jean , Macris Nicolas
Published: August 2020

We consider a statistical model for finite-rank symmetric tensor factorization and prove a single-letter variational expression for its asymptotic mutual information when the tensor is of even order. The proof applies the adaptive interpolation method originally invented for rank-one factorization. Here we show how to extend the adaptive interpolation to finite-rank and even-order tensors. This requires new non-trivial ideas with respect to the current analysis in the literature. We also underline where the proof falls short when dealing with odd-order tensors.
Hemolytic Membrane Vesicles of Group B Streptococcus Promote Infection
Authors: Armistead Blair , Quach Phoenicia , Snyder Jessica M , Santana-Ufret Verónica , Furuta Anna , Brokaw Alyssa , Rajagopal Lakshmi
Published: August 2020

Background

Group B streptococci (GBS) are β-hemolytic, Gram-positive bacteria associated with fetal injury, preterm birth, spontaneous abortion, and neonatal infections. A key factor promoting GBS virulence is the β-hemolysin/cytolysin, a pigmented ornithine rhamnolipid (also known as granadaene) associated with the bacterial surface.

Methods

A previous study indicated that GBS produce small structures known as membrane vesicles (MVs), which contain virulence-associated proteins. In this study, we show that GBS MVs are pigmented and hemolytic, indicating that granadaene is functionally active in MVs.

Results

In addition, MVs from hyperhemolytic GBS induced greater cell death of neutrophils, T cells, and B cells compared with MVs from isogenic nonhemolytic GBS, implicating MVs as a potential mechanism for granadaene-mediated virulence. Finally, hemolytic MVs reduced oxidative killing of GBS and aggravated morbidity and mortality of neonatal mice infected with GBS.

Conclusions

These studies, taken together, reveal a novel mechanism by which GBS deploy a crucial virulence factor to promote bacterial dissemination and pathogenesis.
The Fibrosis-4 Index Is Associated With Need for Mechanical Ventilation and 30-Day Mortality in Patients Admitted With Coronavirus Disease 2019
Authors: Sterling Richard K , Oakes Tavis , Gal Tamas S , Stevens Michael P , deWit Marjolein , Sanyal Arun J
Published: August 2020

The Fibrosis-4 Index (FIB-4), developed to predict fibrosis in liver disease, was used to identify patients with coronavirus disease 2019 who will require ventilator support as well as those associated with 30-day mortality. Multivariate analysis found obesity (odds ratio [OR], 4.5), diabetes mellitus (OR, 2.55), and FIB-4 ≥2.67 (OR, 3.09) independently associated with need for mechanical ventilation. When controlling for ventilator use, sex, and comorbid conditions, FIB-4 ≥2.67 was also associated with increased 30-day mortality (OR, 8.4 [95% confidence interval, 2.23–31.7]). Although it may not be measuring hepatic fibrosis, its components suggest that increases in FIB-4 may be reflecting systemic inflammation associated with poor outcomes.
Participant compensation in global health research: a case study
Authors: Saleh Sepeedeh , Sambakunsi Henry , Nyirenda Deborah , Kumwenda Moses , Mortimer Kevin , Chinouya Martha
Published: August 2020

Background

Compensation for research participants can be provided for reasons including reimbursement of costs; compensation for time lost, discomfort or inconvenience; or expression of appreciation for participation. This compensation involves numerous ethical complexities, at times entailing competing risks. In the context of transnational research, often incorporating contexts of economic inequality, power differentials and post-colonialism, these issues extend into wider questions of ethical research conduct.

Methods

We describe experiences of conducting a community-based study of air pollution in southern Malawi incorporating ethnographic, participatory and air quality monitoring elements. Decisions surrounding participant compensation evolved in response to changing circumstances in the field.

Results

Attention to careful researcher–participant relationships and responsiveness to community perspectives allowed dynamic, contextualised decision-making around participant compensation. Despite widely cited risks, including but not restricted to undue influence of monetary compensation on participation, we learned that failure to adequately recognise and compensate participants has its own risks, notably the possibility of ‘ethics dumping’.

Conclusions

We recommend active engagement with research participants and communities with integration of contextual insights throughout, including participant compensation, as for all elements of research conduct. Equitable research relationships encompass four central values: fairness, care, honesty and respect.
Assessing the Quality and Reliability of Patient Information Regarding First-Aid for Acute Burns on YouTube
Authors: Parizh David , Effendi Maleeh , Dale Elizabeth , Slater Julia
Published: August 2020

Given ever increasing ease of access to technology, the majority of adults first turn to the internet for medical advice. The world wide web is filled with user-generated content within multiple social media platforms that lack a governing body to validate the information’s accuracy and reliability. The authors performed a qualitative review of first-aid burn resources available on YouTube using two validated scales: Modified Discern and Global Quality Scale. A search was conducted using the term “burn treatment” on September 18, 2019. Of 120 reviewed videos, 59 met their inclusion criteria. 36% (n = 21) of the speakers had formal medical training, with only 12% (n = 7) identified as burn care professionals. The mean views originating from nonmedical speakers (162,675) were more than eight times that originating from burn centers (14,975). The quality of the videos was compared by video source, speaker, and specialty. Burn centers had the highest Modified Discern and Global Quality Scale scores, 2.91 and 2.86, respectively (P < .05). Additionally, the authors were able to demonstrate that there was a statistically significant higher quality of videos when the speaker was a burn care professional or had formal medical training. Unfortunately, their review demonstrated that videos originating from hospital systems and burn centers made up a minority of the online media content. These results illustrate an opportunity for improvement by way of increased content creation to bolster the online presence of the burn community and provide patients with more accurate information.
Venous Thromboembolism Chemoprophylaxis in Burn Patients: A Literature Review and Single-Institution Experience
Authors: Liu Alice , Minasian Raquel A , Maniago Ellen , Justin Gillenwater T , Garner Warren L , Yenikomshian Haig A
Published: August 2020

Hospitalized burn patients meet the criteria for Virchow’s triad (endothelial damage, hypercoagulability, and stasis), predisposing them to venous thromboembolism (VTE). Although the disease burden of VTE suggests a need for prevention in this population, unreliable reported VTE rates, costly and complicated prophylaxis regimens, and chemoprophylaxis risks have prevented the establishment of a universal protocol. This paper reviews thromboprophylaxis practices both in the literature and at our own institution. A systematic review was conducted according to PRISMA guidelines identifying studies pertaining to VTE chemoprophylaxis in burn patients. Additionally, medical records of patients admitted to an American Burn Association-verified burn center between June 2015 and June 2019 were retrospectively reviewed for demographics, chemoprophylaxis, and presence of VTE defined as either deep vein thrombosis (DVT) or pulmonary embolism (PE). Thirty-eight studies met inclusion criteria. In the 12 studies that reported VTE incidence, rates ranged widely from 0.25% to 47.1%. The two largest retrospective studies (n = 33,637 and 36,638) reported a VTE incidence of 0.61% and 0.8% in populations with unknown or inconsistently recorded chemoprophylaxis. Throughout the literature, prevention protocols were mixed, though a trend toward using dose-adjusted subcutaneous low molecular weight heparin based on serum anti-factor Xa level was noted. At our burn center, 1,068 patients met study criteria. At-risk patients received a simple chemoprophylaxis regimen of 5000U of subcutaneous unfractionated heparin every 8 hours. No routine monitoring tests were performed to limit cost. Nine cases of DVT and two cases of PE were identified with an incidence of 0.84% and 0.19%, respectively, and a total VTE incidence of 1.03%. Only one patient developed heparin-induced thrombocytopenia (HIT). No cases of other heparin-associated complications were observed. VTE incidence rates reported in the literature are wide-ranging and poorly capture the effect of any one chemoprophylaxis regimen in the burn population. Our center uses a single, safe, and cost-effective protocol effecting a low VTE rate comparable to that of large national retrospective studies.
Susceptibility of Physalis longifolia (Solanales: Solanaceae) to Bactericera cockerelli (Hemiptera: Triozidae) and ‘Candidatus Liberibacter solanacearum’
Authors: Reyes Corral Cesar A , Cooper W Rodney , Horton David R , Karasev Alexander V
Published: August 2020

The potato psyllid, Bactericera cockerelli (Šulc), is a major pest of potato (Solanum tuberosum L.; Solanales: Solanaceae) as a vector of ‘Candidatus Liberibacter solanacearum’, the pathogen that causes zebra chip. Management of zebra chip is challenging in part because the noncrop sources of Liberibacter-infected psyllids arriving in potato remain unknown. Adding to this challenge is the occurrence of distinct genetic haplotypes of both potato psyllid and Liberibacter that differ in host range. Longleaf groundcherry (Physalis longifolia Nutt.) has been substantially overlooked in prior research as a potential noncrop source of Liberibacter-infected B. cockerelli colonizing fields of potato. The objective of this study was to assess the suitability of P. longifolia to the three common haplotypes of B. cockerelli (central, western, and northwestern haplotypes), and to two haplotypes of ‘Ca. L. solanacearum’ (Liberibacter A and B haplotypes). Greenhouse bioassays indicated that B. cockerelli of all three haplotypes produced more offspring on P. longifolia than on potato and preferred P. longifolia over potato during settling and egg-laying activities. Greenhouse and field trials showed that P. longifolia was also highly susceptible to Liberibacter. Additionally, we discovered that infected rhizomes survived winter and produced infected plants in late spring that could then be available for psyllid colonization and pathogen acquisition. Results show that P. longifolia is susceptible to both B. cockerelli and ‘Ca. L. solanacearum’ and must be considered as a potentially important source of infective B. cockerelli colonizing potato fields in the western United States.
Ecology and social biology of the southern three-banded armadillo (Tolypeutes matacus; Cingulata: Chlamyphoridae)
Authors: Attias N , Gurarie E , Fagan W F , Mourão G
Published: August 2020

Basic knowledge of species biology and ecology is essential for the assessment of species conservation status and planning for efficient conservation strategies; however, this information is not always readily available. Here we use movement behavior to understand the ecology and social biology of the poorly known southern three-banded armadillo (Tolypeutes matacus). We used VHF and GPS telemetry to monitor 26 individuals from two sites in the Pantanal wetlands of Brazil. We characterized armadillo activity patterns, evaluated the relationship between sex and body mass with home range size and mean daily distance traveled, and examined home and core range overlap. Three-banded armadillos were active on average for 5.5 ± 2.8 h/day, with most of their activity concentrated in the first half of the night. Adult males were heavier and had larger home ranges than adult females. Home range size scaled positively with body mass for males, but not for females. Core ranges for females overlapped little (< 1%) regardless of age, but home ranges for males overlapped both with other males (12%) and females (18%). Our data suggest that three-banded armadillos are mainly a nocturnal species. Home range and spacing patterns point to a generally asocial behavior and a polygynous or promiscuous mating system. We hope that the data generated as a result of this project will contribute to this species’ conservation in Brazil and elsewhere by guiding future management and research efforts.
Pediatric Inflammatory Multisystem Syndrome: Time to Collaborate
Authors: Kanthimathinathan Hari Krishnan , Scholefield Barnaby R
Published: August 2020

There is significant variability in the names and case definition of pediatric inflammatory multisystem syndrome associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Such variability leads to adverse consequences in the quest for further knowledge and management strategies. It is time to collaborate to gain consensus.
Management of a large delayed esophageal perforation in a fresh liver transplant patient with endoscopic placement of a nasopleural drainage tube—a case report
Authors: Seth Rashmi , Dubrovsky Genia , Busuttil Ronald W , Cameron Robert B
Published: August 2020

Esophageal perforation in liver transplant recipients is a rare phenomenon. We herein report a case of an esophageal perforation due to Sengstaken–Blakemore tube in a liver-transplant recipient diagnosed 6 weeks post-transplant. A 2.5-cm mid-esophageal perforation communicating with large complex fluid collection in the pleural space was found. During endoscopy, 16Fr Salem Sump nasopleural tube (NP) was placed traversing through esophageal perforation into inferior aspect of the collection. Over the following 4 weeks, NP decompressed the cavity, allowed its closure and the tube was slowly retracted. By the end of 4 weeks, NP was removed with follow-up esophagogram showing no extravasation of contrast and a healed perforation. Hence, the esophageal perforation was successfully treated via this unique nonoperative approach without the need for major surgery. In instances of chronic leak with a stable patient, this nonoperative strategy should be considered even in immunocompromised patients.
On the absorption properties of metallic needles
Authors: Xiao C Y , Li Qi , Li Aigen , Chen J H
Published: August 2020

Needle-like metallic particles have been suggested to explain a wide variety of astrophysical phenomena, ranging from the mid-infrared interstellar extinction to the thermalization of starlight to generate the cosmic microwave background. These suggestions rely on the amplitude and the wavelength dependence of the absorption cross-sections of metallic needles. On the absence of an exact solution to the absorption properties of metallic needles, their absorption cross-sections are often derived from the antenna approximation. However, it is shown here that the antenna approximation is not an appropriate representation, since it violates the Kramers–Kronig relation. Stimulated by the recent discovery of iron whiskers in asteroid Itokawa and graphite whiskers in carbonaceous chondrites, we call for rigorous calculations of the absorption cross-sections of metallic needle-like particles, presumably with the discrete dipole approximation. We also call for experimental studies of the formation and growth mechanisms of metallic needle-like particles as well as experimental measurements of the absorption cross-sections of metallic needles of various aspect ratios over a wide wavelength range to bound theoretical calculations.
Metric Manipulations in Post-Tonal Music
Authors: Sullivan James
Published: August 2020

This article explores the continued use of eighteenth-century metric manipulations by composers of the twentieth and twenty-first centuries. These manipulations, called imbroglio, close imitation, and imitative imbroglio, are motive-driven and involve the perceptual interaction of meter, motivic parallelism, and perceptual streaming. Their defining features and local perceptual effects, which primarily involve metrical dissonance, are demonstrated in short passages by Schoenberg, Penderecki, Britten, Debussy, Webern, Barber, and Adès. Their larger form-functional and text-expressive potential is demonstrated in analyses of longer passages by Schoenberg, Webern, and Barber.
TREND-DB—a transcriptome-wide atlas of the dynamic landscape of alternative polyadenylation
Authors: Marini Federico , Scherzinger Denise , Danckwardt Sven
Published: August 2020

Alternative polyadenylation (APA) profoundly expands the transcriptome complexity. Perturbations of APA can disrupt biological processes, ultimately resulting in devastating disorders. A major challenge in identifying mechanisms and consequences of APA (and its perturbations) lies in the complexity of RNA 3′ end processing, involving poorly conserved RNA motifs and multi-component complexes consisting of far more than 50 proteins. This is further complicated in that RNA 3′ end maturation is closely linked to transcription, RNA processing and even epigenetic (histone/DNA/RNA) modifications. Here, we present TREND-DB (http://shiny.imbei.uni-mainz.de:3838/trend-db), a resource cataloging the dynamic landscape of APA after depletion of >170 proteins involved in various facets of transcriptional, co- and post-transcriptional gene regulation, epigenetic modifications and further processes. TREND-DB visualizes the dynamics of transcriptome 3′ end diversification (TREND) in a highly interactive manner; it provides a global APA network map and allows interrogating genes affected by specific APA-regulators and vice versa. It also permits condition-specific functional enrichment analyses of APA-affected genes, which suggest wide biological and clinical relevance across all RNAi conditions. The implementation of the UCSC Genome Browser provides additional customizable layers of gene regulation accounting for individual transcript isoforms (e.g. epigenetics, miRNA-binding sites and RNA-binding proteins). TREND-DB thereby fosters disentangling the role of APA for various biological programs, including potential disease mechanisms, and helps identify their diagnostic and therapeutic potential.
What Are Petitions Good for? Institutional Design and Democratic Functions
Authors: Rosenberger Sieglinde , Seisl Benedikt , Stadlmair Jeremias , Dalpra Elio
Published: August 2020

Parliamentary efforts to facilitate wider participation and specialised online platforms have made petition instruments more attractive and relevant, yet comparisons of petition instruments are rare. This article examines formalised (parliamentary petitions) and non-formalised petition instruments (online petitions) in Austria via a cluster analysis of actors and content of 600 petitions between 2011 and 2018. We find that, depending on the legal and institutional design, different petition instruments serve three different democratic functions: voice in parliament, link with constituents and public mobilisation. Complementing these results with insights from expert interviews with petitioners, the article provides also an understanding of how petition instruments affect petitioners’ motivations. Our findings yield a more nuanced picture of the motivations and functions of petition instruments.