bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathological slow-wave activity and impaired working memory binding in post-traumatic amnesia
Authors: Mallas Emma-Jane , Gorgoraptis Nikos , Dautricourt Sophie , Pertzov Yoni , Scott Gregory , Sharp David J.
Published: December 2021

The mechanism by which information is bound together in working memory is a central question for cognitive neuroscience. This binding is transiently disrupted during periods of post-traumatic amnesia following significant head injuries. The reason for this impairment is unclear but may be due to electrophysiological changes produced by head impacts. These are common and include pathological low frequency activity, which is associated with poorer neurological outcomes and may disrupt cortical communication. Here, we investigate associative memory binding during post-traumatic amnesia and test the hypothesis that misbinding is caused by a disruption in cortical communication produced by the pathological slowing of brain activity. Thirty acute moderate-severe traumatic brain injury patients (mean time since injury = 10 days) and 26 healthy controls were tested with a precision working memory paradigm that required the association of object and location information. A novel entropy ratio measure was calculated from behavioural performance. This provided a continuous measure of the degree of misbinding and the influence of distracting information. Resting state EEG was used to assess the electrophysiological effects of traumatic brain injury. Patients in post-traumatic amnesia showed abnormalities in working memory function and made significantly more misbinding errors than patients who were not in post-traumatic amnesia and controls. Patients showed a higher entropy ratio in the distribution of spatial responses, indicating that working memory recall was abnormally biased by the locations of non-target items suggesting a specific impairment of object and location binding. Slow wave activity was increased following traumatic brain injury. Increases in the delta-alpha ratio indicative of an increase in low frequency power specifically correlated with binding impairment in working memory. In contrast, although connectivity was increased in the theta band and decreased in the alpha band after traumatic brain injury, this did not correlate with working memory impairment. Working memory and electrophysiological abnormalities both normalised at six-month follow-up, in keeping with a transient increase in slow-wave activity causing post-traumatic amnesia that impaired working memory function. These results show that patients in post-traumatic amnesia show high rates of working memory misbinding that are associated with a pathological shift towards lower frequency oscillations.
Genomic surveillance reveals the emergence of SARS-CoV-2 Lineage A from Islamabad Pakistan
Authors: Umair Massab , Ikram Aamer , Rehman Zaira , Haider Syed Adnan , Badar Nazish , Ammar Muhammad , Ali Qasim , Ahad Abdul , Suleman Rana , Salman Muhammad
Published: December 2021

The lineage A of SARS-CoV-2 has been around the world since the start of the pandemic. In Pakistan the last case of lineage A was reported in April, 2021 since then no case has been reported. In November, 2021 during routine genomic surveillance at National Institute of Health we have found 07 cases of lineage A from Islamabad, Pakistan. The study reports two novel deletions in the spike glycoprotein. One 09 amino acid deletion (68-76 a.a) is found in the S1 subunit while another 10 amino acid deletion (679-688 a.a) observed at the junction of S1/S2 referred as furin cleavage site. The removal of furin cleavage site may result in impaired virus replication thus decreasing its pathogenesis. The actual impact of these two deletions on the virus replication and disease dynamics needs to be studied in detail. Moreover, the enhanced genomic surveillance will be required to track the spread of this lineage in other parts of the country.
Causal attribution fractions, and the attribution of smoking and BMI to the landscape of disease incidence in UK Biobank
Authors: Webster Anthony J.
Published: December 2021

Unlike conventional epidemiological studies that use observational data to estimate “associations” between risk factors and disease, the science of causal inference has identified situations where causal estimates can be made from observational data, using results such as the “backdoor criteria”. These results are combined here with established epidemiological methods, to calculate simple population attribution fractions that estimate the causal influence of risk factors on disease incidence, and can be estimated using conventional proportional hazards methods. A counterfactual argument gives an attribution fraction for individuals. Causally meaningful attribution fractions cannot be constructed for all risk factors or confounders, but they can for the important established risk factors of smoking and body mass index (BMI). Using the new results, the causal attribution of smoking and BMI to the incidence of 226 diseases in the UK Biobank are estimated, and summarised in terms of disease chapters from the International Classification of Diseases (ICD-10). The diseases most strongly attributed to smoking and BMI are identified, finding 11 with attribution fractions greater than 0.5, and a small number with protective associations. The results provide new tools to quantify the causal influence of risk factors such as smoking and BMI on disease, and survey the causal influence of smoking and BMI on the landscape of disease incidence in the UK Biobank population.
Relative Importance of Various Inflammatory Markers and Their Critical Thresholds for COVID-19 Mortality
Authors: Budhiraja Sandeep , Indrayan Abhaya , Das Poonam , Dewan Arun , Singh Omender , Nangia Vivek , Singh Y P , Pandey Rajesh , Gupta Ajay Kumar , Gupta Manish , Bhasin Deepak , Uniyal Bhupesh , Mathur Mohit , Pawar Mayur
Published: December 2021

Background

Various inflammatory markers are commonly assessed in many patients to help in the management of COVID-19 patients. It is not clear, though, how much risk of mortality their different levels of elevations entail, and which marker signifies more risk than others and how much. This study was undertaken to describe their levels and to answer these questions regarding eight inflammatory markers, namely, CRP, D-dimer, ferritin, IL-6, LDH, CPK, troponin-I.

Methods

The data were retrieved from the electronic records of 19852 CoViD-19 patients admitted to a chain of hospitals in north India from March 2020 to July 2021. Levels for most markers were available for more than 10,000 patients. In view of widely different ranges of values of different markers, we divided their values into quintiles (Qs) and studied the pattern of mortality and for running the logistic regression. In addition, logarithm transformation was also tried. The statistical distribution of the values was compared by Mann-Whitney test. Relative importance was judged by the mortality rates, area under the ROC curves (AUROCs), and the odds ratios.

Results

Although the mortality increased with decreasing ALC and increasing level of all the other markers, more than 70% survived even with levels in the extreme quintile. The adjusted odds ratio was the highest (7.62) for the Q5 levels of IL-6, closely followed by D-dimer (OR = 6.04). The AUROC was the highest (0.817) for LDH and the least (0.612) for CPK. However, the optimal cut-off for any marker could correctly classify not more than 80% deaths and the multivariable logistic regression could correctly classify patients with mortality in less than 24% cases.

Conclusion

Although elevated levels of all the markers and low values of ALC were significant risk factor but no firm evidence was available for any of the eight markers to be a major indicator of the mortality in COVID-19 unless they reach to a critical threshold. Among those studied, D-Dimer (>192 ng/mL) followed by IL-6 (>4.5 pg/mL) had stronger association with mortality even with moderate and higher end of the normal levels and LDH (>433 U/L) and troponin-I (>0.002ng/mL) with only steeply increased levels. Ferritin had modest association, and CPK, CRP and ALC were a relatively poor risk of mortality.
Applying Benford’s law to COVID-19 data: The case of the European Union
Authors: Kolias Pavlos
Published: December 2021

Previous studies have used Benford’s distribution to assess whether there is misreporting of COVID-19 cases and deaths. Data inaccuracies provide false information to the media, undermine global response, and hinder the preventive measures taken by countries worldwide. In this study, daily new cases and deaths from all the countries of the European Union were analyzed and the conformance to Benford’s distribution was estimated. For each country, two statistical tests and two measures of deviation were calculated to determine whether the reported statistics comply with the expected distribution. Four country-level developmental indexes were also included, the GDP per capita, health expenditures, the Universal Health Coverage index, and the full vaccination rate. Regression analysis was implemented to show whether the deviation from Benford’s distribution is affected by the aforementioned indexes. The findings indicate that four countries were in line with the expected distribution, Bulgaria, Croatia, Lithuania, and Romania. For the daily cases, Denmark, Greece, and Ireland, showed the greatest deviation from Benford’s distribution and for deaths, Malta, Cyprus, Greece, Italy, and Luxemburg exhibited the highest deviation from Benford’s law. Furthermore, it was found that the vaccination rate is positively associated with deviation from Benford’s distribution. These results suggest that overall, official data provided by authorities are not confirming Benford’s law, yet this approach is not conclusive; it acts as a preliminary tool for data verification. More extensive studies should be made with a more thorough investigation of countries that showed the greatest deviation.
Selection on modifiers of genetic architecture under migration load
Authors: Proulx Stephen R. , Teotónio Henrique
Published: December 2021

Gene flow between populations adapting to differing local environmental conditions might be costly because individuals can disperse to habitats where their survival is low or because they can reproduce with locally maladapted individuals. The amount by which the mean relative population fitness is kept below one creates an opportunity for modifiers of the genetic architecture to spread due to selection. Prior work that separately considered modifiers changing dispersal, recombination rates, or altering dominance or epistasis, has typically focused on the direction of selection rather than its absolute magnitude. We here develop methods to determine the strength of selection on modifiers of the genetic architecture, including modifiers of the dispersal rate, in populations that have previously evolved local adaptation. We consider scenarios with up to five loci contributing to local adaptation and derive a new model for the deterministic spread of modifiers. We find that selection for modifiers of epistasis and dominance is stronger than selection for decreased recombination, and that selection for partial reductions in recombination are extremely weak, regardless of the number of loci contributing to local adaptation. The spread of modifiers that reduce dispersal depends on the number of loci, epistasis and extent of local adaptation in the ancestral population. We identify a novel effect, that modifiers of dominance are more strongly selected when they are unlinked to the locus that they modify. These findings help explain population differentiation and reproductive isolation and provide a benchmark to compare selection on modifiers under finite population sizes and demographic stochasticity.

Author Summary

When populations of a species are spread over different habitats the populations can adapt to their local conditions, provided dispersal between habitats is low enough. Natural selection allows the populations to maintain local adaptation, but dispersal and gene flow create a cost called the migration load. The migration load measures how much fitness is lost because of dispersal between different habitats, and also creates an opportunity for selection to act on the arrangement and interaction between genes that are involved in local adaptation. Modifier genes can spread in these linked populations and cause functional, local adaptation genes, to become more closely linked on a chromosome, or change the way that these genes are expressed so that the locally adapted gene copy becomes dominant. We modeled this process and found that selection on modifiers that create tighter linkage between locally adapted genes is generally weak, and modifiers that cause gene interactions are more strongly selected. Even after these gene interactions have begun to evolve, further selection for increased gene interaction is still strong. Our results show that populations are more likely to adapt to local conditions by evolving new gene interactions than by evolving tightly linked gene clusters.
Cell-type specific neuromodulation of excitatory and inhibitory neurons via muscarinic acetylcholine receptors in layer 4 of rat barrel cortex
Authors: Qi Guanxiao , Feldmeyer Dirk
Published: December 2021

The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties. Here, we investigated how a low concentration of ACh (30 µM) affects the intrinsic properties of electrophysiologically and morphologically identified excitatory and inhibitory neurons in layer 4 (L4) of rat barrel cortex. ACh altered the membrane potential of L4 neurons in a heterogeneous manner. Nearly all L4 regular spiking (RS) neurons responded to bath-application of ACh with a M4 muscarinic ACh receptor-mediated hyperpolarisation. In contrast, in the majority of L4 fast spiking (FS) and non-fast spiking (nFS) interneurons 30 µM ACh induced a depolarisation while the remainder showed a hyperpolarisation or no response. The ACh-induced depolarisation of L4 FS interneurons was much weaker than that in L4 nFS interneurons. There was no clear difference in the response to ACh for three morphological subtypes of L4 FS interneurons. However, in four morpho-electrophysiological subtypes of L4 nFS interneurons, VIP+-like interneurons showed the strongest ACh-induced depolarisation; occasionally, even action potential (AP) firing was elicited. The ACh-induced depolarisation in L4 FS interneurons was exclusively mediated by M1 muscarinic ACh receptors; in L4 nFS interneurons it was mainly mediated by M1 and/or M3/5 muscarinic ACh receptors. In a subset of L4 nFS interneurons, a co-operative activation of nicotinic ACh receptors was also observed. The present study demonstrates that low-concentrations of ACh affect the different L4 neurons types in a cell-type specific way. These effects result from a specific expression of different muscarinic and/or nicotinic ACh receptors on the somatodendritic compartments of L4 neurons. This suggests that even at low concentrations ACh may tune the excitability of L4 excitatory and inhibitory neurons and their synaptic microcircuits differentially depending on the behavioural state during which ACh is released.
Terpene volatiles mediates the chemical basis of blueberry aroma and consumer acceptability
Authors: Ferrão Luis Felipe V. , Sater Haley , Lyrene Paul , Amadeu Rodrigo R. , Sims Charlie , Tieman Denise , Munoz Patricio R.
Published: December 2021

Among the main features treasured by blueberry consumers, flavor is the most important. Human perception of food flavors can primarily be divided into two main sensory inputs, taste and aroma. Through retronasal olfaction, a group of metabolites called volatile organic compounds (VOCs) emitted from the fruit are able to produce the sensation of aroma, creating the myriad of flavors experienced during our life. In blueberry, breeders have noticed some genotypes with unique floral and sweet flavor notes that, ultimately, enhance human aroma perception. Despite the importance, both the understanding of which chemicals are mediating this variation across phenotypes and the potential impact on consumer preferences remains largely unknown. In this study we dissected the main components underlying blueberry aroma and associated it with consumer predilections by paring metabolomics with sensory analysis. Our contribution in this study is four-fold: (i) first, based on a representative blueberry germplasm cultivated at the University of Florida, we differentiated genotypes with floral and sweet aromatic notes and confirmed that such unique characteristics are preferred by consumers; (ii) at the chemical level, we showed that a group of eight terpene volatiles constitute the primary metabolic group associated with aroma sensation; (iii) we demonstrated that aromatic genotypes can be classified using information from a group of a few key volatiles; and finally, (iv) we combined pedigree and metabolomic information in a single predictive framework and showed the importance of metabolomic data for flavor-assisted selection. For the blueberry community, our findings open new venues to explore flavor. Broadly, we present an emerging view about flavor and provide a detailed blueprint of how this target could be addressed in fruits and vegetables.
OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum
Authors: Beyrend Guillaume , van der Sluis Tetje C. , van der Gracht Esmé T.I. , Abdelaal Tamim , Jochems Simon P. , Belderbos Robert A. , Wesselink Thomas H. , van Duikeren Suzanne , van Haften Floortje J. , Redeker Anke , Nejad Elham Beyranvand , Camps Marcel , Franken Kees LMC , Linssen Margot M. , Hohenstein Peter , de Miranda Noel F.C.C. , Mei Hailiang , Bins Adriaan D. , Haanen John B.A.G. , Aerts Joachim G. , Ossendorp Ferry , Arens Ramon
Published: December 2021

Immune checkpoint therapy (ICT) has the potency to eradicate cancer but the mechanisms that determine effective versus non-effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling we examined whether T cell states in the blood circulation could predict responsiveness to a combined ICT, sequentially targeting OX40 costimulatory and PD-1 inhibitory pathways, which effectively eradicated syngeneic mouse tumors. Unbiased assessment of transcriptomic alterations by single-cell RNA sequencing and profiling of cell-surface protein expression by mass cytometry revealed unique activation states for therapy-responsive CD4+ and CD8+ T cells. Effective ICT elicited T cells with dynamic expression of distinct NK cell and chemokine receptors, and these cells were systemically present in lymphoid tissues and in the tumor. Moreover, NK cell receptor-expressing CD8+ T cells were also present in the peripheral blood of immunotherapy-responsive cancer patients. Targeting of the NK cell and chemokine receptors in tumor-bearing mice showed their functional importance for therapy-induced anti-tumor immunity. These findings provide a better understanding of ICT and highlight the use of dynamic biomarkers on effector CD4+ and CD8+ T cells to improve cancer immunotherapy.
TaEXPB5 is responsible for male fertility in thermo-sensitive male-sterility wheat with Aegilops kotschyi cytoplasm
Authors: Geng Xingxia , Wang Xiaoxia , Wang Jingchen , Yang Xuetong , Zhang Lingli , Song Xiyue
Published: December 2021

Thermo-sensitive male sterility is of vital importance to heterosis, or hybrid vigor in crop production and hybrid breeding. Therefore, it is meaningful to study the function of the genes related to pollen development and male sterility, which is still not fully understand currently. Here, we conducted comparative analyses to screen fertility related genes using RNA-seq, iTRAQ, and PRM-based assay. A gene encoding expansin protein in wheat, TaEXPB5, was isolated in KTM3315A, which was in the cell wall and preferentially upregulated expression in the fertility anthers. The silencing of TaEXPB5 displayed pollen abortion, the declination or sterility of fertility. Further, cytological investigation indicated that the silencing of TaEXPB5 induced the early degradation of tapetum and abnormal development of pollen wall. These results revealed that the silencing of TaEXPB5 could eliminate the effects of temperature on male fertility, and resulting in functional loss of fertility conversion, which implied that TaEXPB5 may be essential for anther or pollen development and male fertility of KTM3315A. These findings provide a novel insight into molecular mechanism of fertility conversion for thermo-sensitive cytoplasmic male-sterility wheat, and contribute to the molecular breeding of hybrid wheat in the future.

Highlight

TaEXPB5 coffers to anther or pollen development and male fertility in KTM3315A, its silencing could eliminate the effects of temperature on male fertility, and resulting in functional loss of fertility conversion.
Valosin-containing protein regulates the stability of amyotrophic lateral sclerosis-causing fused in sarcoma granules in cells by changing ATP concentrations inside the granules
Authors: Yasuda Kyota , Watanabe Tomonobu M. , Kang Myeong-Gyun , Seo Jeong Kon , Rhee Hyun-Woo , Tate Shin-ichi
Published: December 2021

Fused in sarcoma (FUS) undergoes liquid-liquid phase separation (LLPS) to form granules in cells, leading to pathogenic aggregations that cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Proteomics analysis revealed that FUS granules contain valosin-containing protein (VCP), a member of the AAA family ATPase. Confocal microscopy images showed that VCP co-localized in the FUS granules in cells. This study demonstrates that VCP in granules has a two-faced role in FUS granulation: VCP stabilizes de novo FUS granules, while VCP present in the granules for extended periods dissolves them. This VCP function relies on its ATPase activity to consume ATP in granules. VCP stabilizes de novo FUS by reducing intragranular ATP concentrations to a range below the cytosolic concentration. VCP continually consumes ATP during its stay in the granules, which eventually lowers ATP concentrations to a range that destabilizes the granules. VCP, therefore, acts as a timer to limit the residence of FUS granules in cells and thereby prohibits the FUS fibrillization that occurs in persistent granules. VCP ATPase activity plays a role in FUS granule turnover.

Summary statement

VCP recruited to FUS granules regulates the stability of the granules in a time-dependent manner by consuming intragranular ATP with its ATPase activity.
Serial interval and basic reproduction number of SARS-CoV-2 Omicron variant in South Korea
Authors: Kim Dasom , Jo Jisoo , Lim Jun-Sik , Ryu Sukhyun
Published: December 2021

South Korea is experiencing the community transmission of the SARS-CoV-2 Omicron variant (B.1.1.529). We estimated that the mean (± standard deviation) serial interval was 2.22 (± 1.62) days, and the basic reproduction number was 1.90 (95% Credible Interval, 1.50–2.43) for the Omicron variant outbreak in South Korea.
Ultra-high-speed multi-parametric photoacoustic microscopy
Authors: Zhong Fenghe , Hu Song
Published: December 2021

Multi-parametric photoacoustic microscopy (PAM) is uniquely capable of simultaneous, high-resolution mapping of blood hemoglobin concentration, oxygenation, and flow in vivo. However, its speed has been limited by the dense sampling required for blood flow quantification. To overcome this limitation, we have developed an ultra-high-speed multi-parametric PAM system, which enables simultaneous acquisition of ~500 densely sampled B-scans by superposing the rapid laser scanning across the line-shaped focus of a cylindrically focused ultrasonic transducer over the conventional mechanical scan of the optical-acoustic dual foci. A novel optical-acoustic combiner is designed and implemented to accommodate the short working distance of the transducer, enabling convenient confocal alignment of the dual foci in the reflection mode. This new system enables continuous monitoring of microvascular hemoglobin concentration, blood oxygenation, and flow over a 4.5 × 3 mm2 area in the awake mouse brain with high spatial and temporal resolution (6.9 μm and 0.3 Hz, respectively).
Joint dimension reduction and clustering analysis for single-cell RNA-seq and spatial transcriptomics data
Authors: Liu Wei , Liao Xu , Yang Yi , Lin Huazhen , Yeong Joe , Zhou Xiang , Shi Xingjie , Liu Jin
Published: December 2021

Dimension reduction and (spatial) clustering is usually performed sequentially; however, the low-dimensional embeddings estimated in the dimension-reduction step may not be relevant to the class labels inferred in the clustering step. We therefore developed a computation method, Dimension-Reduction Spatial-Clustering (DR-SC), that can simultaneously perform dimension reduction and (spatial) clustering within a unified framework. Joint analysis by DR-SC produces accurate (spatial) clustering results and ensures the effective extraction of biologically informative low-dimensional features. DR-SC is applicable to spatial clustering in spatial transcriptomics that characterizes the spatial organization of the tissue by segregating it into multiple tissue structures. Here, DR-SC relies on a latent hidden Markov random field model to encourage the spatial smoothness of the detected spatial cluster boundaries. Underlying DR-SC is an efficient expectation-maximization algorithm based on an iterative conditional mode. As such, DR-SC is scalable to large sample sizes and can optimize the spatial smoothness parameter in a data-driven manner. With comprehensive simulations and real data applications, we show that DR-SC outperforms existing clustering and spatial clustering methods: it extracts more biologically relevant features than conventional dimension reduction methods, improves clustering performance, and offers improved trajectory inference and visualization for downstream trajectory inference analyses.
Exploring careers through a qualitative lens: an investigation and invitation
Authors: Richardson Julia , O'Neil Deborah Anne , Thorn Kaye
Published: December 2021

Purpose

In this paper, the authors investigate and celebrate the contributions that qualitative research has made to Career Development International (CDI) and careers scholarship over the past 25 years. The authors highlight the positive impact of understanding the “lived/emic experiences” of individual career actors using qualitative research designs and identify areas for future research.

Design/methodology/approach

The authors employ multiple approaches in their investigation. The authors’ enquiry is part conceptual, part critical analysis and part bibliometric visualisation of qualitative papers published in CDI.

Findings

The authors identify the underlying ontological and epistemological assumptions of qualitative research, and the key tenets and contributions of qualitative research published in CDI. Their bibliometric analysis shows the interrelatedness and frequency of topics addressed by qualitative research and published in CDI, revealing areas for further research. While identifying some of the key criteria for rigor in qualitative research, the authors also engage with emerging calls to avoid rigid templates in how qualitative research is designed and implemented. In this regard, authors echo calls for “methodological bricolage” as an approach to qualitative research in the study of careers.

Originality/value

This is the first bibliographic and visual analysis of qualitative research published in a single journal. The authors offer this investigation as a way of looking back and as an invitation looking forward, encouraging further qualitative research in anticipation of future theoretical developments in career scholarship.
Meta-analysis of the impact of cross-cultural training on adjustment, cultural intelligence, and job performance
Authors: Chenyang Li
Published: December 2021

Purpose

This research aims to provide an updated meta-analysis of cross-cultural training effectiveness through quantitatively reviewing the links between cross-cultural training and three outcomes: adjustment, cultural intelligence and job performance.

Design/methodology/approach

Drawing from 37 independent samples from 1991 through August 2021 involving a total of 7,040 trainees, the author adopt random-effects meta-analyses method to assess the relationships between cross-cultural training and three outcomes and examine potential moderators (i.e. training phase, training method and rating source) that influence these relationships.

Findings

The meta-analytical results mainly support our hypotheses. Cross-cultural training -adjustment exhibits a medium and significant positive effect, whereas cross-cultural training is positive significantly related to job performance and cultural intelligence of small effect sizes. Training method and data source significantly moderate the cross-cultural training's impact on cultural intelligence and performance correspondingly.

Originality/value

This study considers longitudinal statistics for measuring cross-cultural training effectiveness, breaking down the inadequacy of cross-sectional measurement and covers sub-dimensions of cross-cultural training outcomes to provide more comprehensive and advanced evidence of cross-cultural training effectiveness for the latest 30 years.
The role of academic conferences in the [re]production of gender inequality in business disciplines: not just a STEM problem
Authors: Walters Trudie , Hassanli Najmeh , Finkler Wiebke
Published: December 2021

Purpose

In this paper the authors seek to understand how academic conferences [re]produce deeply embedded gendered patterns of interaction and informal norms within the business disciplines.

Design/methodology/approach

Drawing on Acker's (2012) established and updated theory of gendered organisations, the authors focus on the role of academic conferences in the reproduction of gendered practices in the business disciplines. The authors surveyed academics at top universities in Australia and New Zealand who had attended international conferences in their discipline area.

Findings

Academic conferences in the business disciplines communicate organisational logic and act as gendered substructures that [re]produce gendered practices, through the hierarchy of conference participation. Even in disciplinary conferences with a significant proportion of women delegates, the entrenched organisational logic is manifest in the bodies that perform keynote and visible expert roles, perpetuating the notion of the “ideal academic” as male.

Practical implications

The authors call for disciplinary associations to formulate an equality policy, which covers all facets of conference delivery, to which institutions must then respond in their bid to host the conference and which then forms part of the selection criteria; explicitly communicate why equality is important and what decisions the association and hosts took to address it; and develop databases of women experts to remove the most common excuse for the lack of women keynote speakers. Men, question conference hosts when asked to be a keynote speaker or panelist: Are half of the speakers women and is there diversity in the line-up? If not, provide the names of women to take your place.

Originality/value

The contribution of this study is twofold. First is the focus on revealing the underlying processes that contribute to the [re]production of gender inequality at academic conferences: the “how” rather than the “what”. Second, the authors believe it to be the first study to investigate academic conferences across the spectrum of business disciplines.
Bringing ethics into governance: the case of the UK COVID-19 contact tracing app
Authors: Samuel Gabrielle , Lucivero Federica
Published: December 2021

Purpose

In April 2020, it was announced that NHSX, a unit of the UK National Health Service (NHS) responsible for digital innovation, was developing a contact tracing app that would offer a digital solution to managing the COVID-19 pandemic. Despite the urgency with which the app was developed, a clear commitment was made to designing the technology in a way that enshrined key ethical principles, and an ethics advisory board (EAB) was established to provide timely advice, guidance and recommendations on associated ethical issues. Alongside this, there were extensive criticisms of how NHSX adhered to ethical principles in the handling of the app development-criticisms that require empirical exploration. This paper explores how ethics was incorporated into decision-making during governance processes associated with the development of app.

Design/methodology/approach

Interviews were conducted with those involved in the app's development/governance, those with a consulting role associated with the app, or those who sat on the EAB.

Findings

The EAB fulfilled an important role by introducing ethical considerations to app developers. Though at times, it was difficult to accommodate key ethics principles into governance processes, which sometimes suffered from little accountability.

Originality/value

While several articles have provided overviews of ethical issues, or explored public perceptions towards contact tracing apps, to the best the authors, knowledge this is the first empirical piece analysing ethics governance issues via stakeholder interviews.
Uncertainty management in engineering-service development: the role of organisational capabilities
Authors: Ramirez Hernandez Tabea , Kreye Melanie E.
Published: December 2021

Purpose

Engineering-service (ES) development is characterised by high uncertainty, the management of which is crucial for the success of the offering during the provision of ESs. This paper studies suitable organisational capabilities to address different uncertainty types.

Design/methodology/approach

Based on conceptualisation of individual uncertainty types and organisational capabilities, this study investigated their empirical links through six case studies of ES development projects. The data consisted of 64 semi-structured interviews, 10 weeks of observational data and 166 supporting documents describing the projects.

Findings

The findings provide empirical evidence for four distinct uncertainty types (environmental, organisational, technical and relational uncertainty) and the organisational capabilities needed for addressing them. The authors identified unique dominant capabilities for each uncertainty type (commercialisation for environmental uncertainty, coordination for organisational and technical uncertainty, and relational capabilities for relational uncertainty), which were complemented with supporting capabilities, including project management and integration.

Originality/value

This study contributes to the service operations literature by merging previously separate research streams on uncertainty and organisational capabilities in ESs and servitization. Through this merge, this study offers a more coherent understanding by extending previously sporadic insights into specific links between individual uncertainty types and individual capabilities.
Ambiguity in public sector performance measurement: a systematic literature review
Authors: Oppi Chiara , Campanale Cristina , Cinquini Lino
Published: December 2021

Purpose

This paper presents a systematic literature review aiming at analysing how research has addressed performance measurement systems’ (PMSs) ambiguities in the public sector. This paper embraces the ambiguity perspective that PMSs in public sector coexist with and cope with existing ambiguities.

Design/methodology/approach

The authors conducted a literature review in Scopus and ScienceDirect, considering articles published since 1985, and the authors selected articles published in the journals included in the Association of Business Schools' Academic Journal Guide (Chartered ABS, 2018). Of the 1,278 abstracts that matched the study’s search criteria, the authors selected 131 articles for full reading and 37 articles for the final discussion.

Findings

The study's key findings concern the elements of ambiguity in PMSs discussed in the literature. The study’s results suggest that ambiguity is still a relevant problem in performance measurement, as a problem that is impossible to be solved and therefore needs to be better understood by researchers and public managers. The analysis allows us to summarize the antecedents and consequences of ambiguity in the public sector.

Research limitations/implications

The key findings of the study concern the main sources of ambiguity in PMSs discussed in the literature, their antecedents and their consequences. The study results suggest that ambiguity exists in performance measurement and that is an issue to be handled with various strategies that can be implemented by managers and employees.

Practical implications

Managers and researchers may benefit from this research as it may represent a guideline to understand ambiguities in their organizations or in field research. Researchers may also benefit from a summary list of the key issues that have been analysed in the empirical cases provided by this research.

Social implications

This research may provide insights to limit ambiguity and thus contribute to improve performance measurement in the public sector.

Originality/value

This research presents a comprehensive review on the topic. It provides insight that suggests what future research should attend to in helping to interpret ambiguity, considering also what should be done to influence ambiguity.
Are family firms good neighbours? A spatial analysis of Italian technology-intensive firms
Authors: Amato Stefano , Pieroni Valentina , Lattanzi Nicola , Vitali Giampaolo
Published: December 2021

Purpose

A burgeoning body of evidence points out the importance of spatial proximity in influencing firm efficiency besides internal characteristics. Nevertheless, the family status of the firm has been traditionally overlooked in that debate. Therefore, this study aims to investigate productivity spillovers stemming from the geographical closeness to innovators and family firms.

Design/methodology/approach

Using secondary data on Italian technology-intensive manufacturing firms, the paper exploits spatial econometric models to estimate productivity spillovers across firms.

Findings

As regards the presence of spatial dependence, this study reveals that a firm's level of efficiency and productivity is influenced by that of nearby firms. Specifically, three main results emerge. First, spatial proximity to innovators is beneficial for the productivity of neighbouring firms. Second, closeness to family firms is a source of negative externalities for spatially proximate firms. However, and this is the third result, the adverse effect vanishes when the nearby family firms are also innovators.

Research limitations/implications

As the study relies on cross-sectional data, future research should explore productivity spillovers in a longitudinal setting. Additionally, the channels through which productivity spillovers occur should be measured.

Practical implications

The study highlights the importance of co-location for public policy initiatives to strengthen the competitiveness of firms and, indirectly, that of localities and regions. Moreover, the findings show the crucial role of innovation in mitigating the productivity gap between family and non-family firms.

Social implications

Notwithstanding the advent of the digital era, spatial proximity and localized social relationships are still a relevant factor affecting firms' performance.

Originality/value

By exploring the role of family firms in influencing the advantages of geographical proximity, this study contributes to the growing efforts to explore family enterprises across spatial settings.
Too tied to fail: a multidimensional approach to social capital in crowdfunding campaigns. Evidences from Italian agri-food businesses
Authors: Kocollari Ulpiana , Pedrazzoli Alessia , Cavicchioli Maddalena , Girardi Andrea
Published: December 2021

Purpose

The authors investigate the contributions of social capital (SC) dimensions (bridging, bonding and linking) in crowdfunding campaigns by comparing the dynamics of agri-food businesses with those of two other sectors – cultural and technological.

Design/methodology/approach

The authors develop linear regressions on a proprietary data set of 5,290 projects launched on the Italian platform “Produzionidalbasso.com”, from 2014 to 2020.

Findings

The authors’ findings suggest that combining the three social capital dimensions (bridging, bonding and linking) has a more substantial overall effect on the number of backers involved in agri-food projects than in cultural and technological projects. Agri-food entrepreneurs effectively mobilize all resources embedded in the SC dimensions and therefore create the conditions to develop new ties that financially support the project.

Practical implications

Agri-food entrepreneurs may benefit from those results improving their funding strategies. Therefore, agri-food entrepreneurs can explore and exploit the instruments available on the CFD platform – video and rewards associated with the campaign – gaining more benefit from the backers involved compared with other project categories.

Originality/value

The study proposes a broader perspective regarding SC that encompasses the proponent, the company and the campaign with three different types of ties: bonding, bridging and linking. These SC dimensions can differently shape diverse sectors and this eclectic configuration can differentiate the effects of SC in crowdfunding campaigns. This study pinpoints how crowdfunding determinants change, based on project categories.
Bifurcating the dynamic dominant logic: technical and evolutionary patterns of action
Authors: Dwipayana Chandra , Prijadi Ruslan , Hamsal Mohammad
Published: December 2021

Purpose

This study proposed the integrative model of dynamic dominant logic (DL) with exploitation (EP) and exploration (ER) as a pattern of actions in endeavoring firm performance (FP). This study also intended to explain the multiple patterns of DL in creating technical and evolutionary fitness simultaneously.

Design/methodology/approach

This study used a cross-sectional quantitative analysis of the Indonesian commercial banking population facing digital transformation and was analyzed using covariance-based structural equation modeling through parceling.

Findings

The model confirmed that DL positively affects EP and ER. It also revealed that DL indirectly impacts FP through EP, indicating changes in the traditional banking business through the strong acceptance of “new realities” in adapting to the rapid growth of technology. Hence, this study discovered that during the recent banking digital transformation, the beneficial inertia of the technical pattern of action might lose effectiveness in creating superior performance.

Practical implications

DL is vital in locking short-term performance while maintaining long-term performance opportunities through EP and ER to promote digital transformation. Accordingly, it induced banks to adopt new technology for value creation and fortifying competitive advantage.

Originality/value

This study provided a theory about how DL links the firm's decision-making process by promoting multiple patterns of action in achieving technical and evolutionary fitness. It highlighted the DL as a resource conceptualization that promotes resource development through EP and ER as microfoundation of dynamic capabilities during the tension of institutionalization and digital transformation.
Compact dual-mode microstrip bandpass filter based on slotted square patch resonator
Authors: S. Karthie , J. Zuvairiya Parveen , D. Yogeshwari , E. Venkadeshwari
Published: December 2021

Purpose

The purpose of this paper is to present the design of a compact microstrip bandpass filter (BPF) in dual-mode configuration loaded with cross-loop and square ring slots on a square patch resonator for C-band applications.

Design/methodology/approach

In the proposed design, the dual-mode response for the filter is realized with two transmission zeros (TZs) by the insertion of a perturbation element at the diagonal corner of the square patch resonator with orthogonal feed lines. Such TZs at the edges of the passband result in better selectivity for the proposed BPF. Moreover, the cross-loop and square ring slots are etched on a square patch resonator to obtain a miniaturized BPF.

Findings

The proposed dual-mode microstrip filter fabricated in RT/duroid 6010 substrate using PCB technology has a measured minimum insertion loss of 1.8 dB and return loss better than 24.5 dB with a fractional bandwidth (FBW) of 6.9%. A compact size of 7.35 × 7.35 mm2 is achieved for the slotted patch resonator-based dual-mode BPF at the center frequency of 4.76 GHz. As compared with the conventional square patch resonator, a size reduction of 61% is achieved with the proposed slotted design. The feasibility of the filter design is confirmed by the good agreement between the measured and simulated responses. The performance of the proposed filter structure is compared with other dual-mode filter works.

Originality/value

In the proposed work, a compact dual-mode BPF is reported with slotted structures. The conventional square patch resonator is deployed with cross-loop and square ring slots to design a dual-mode filter with a square perturbation element at its diagonal corner. The proposed filter exhibits compact size and favorable performance compared to other dual-mode filter works reported in literature. The aforementioned design of the dual-mode BPF at 4.76 GHz is suitable for applications in the lower part of the C-band.