bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulatory scripting: Stakeholder participation in food and drug administration medical device advisory meetings
Authors: White Shelley K. , Leiter Valerie , Le Mi H. , Helms Caitlyn K.
Published: February 2023

In an age of biomedicalization, medical devices have become more common and more technologically complicated, and adverse events associated with medical devices have increased. The U.S. Food and Drug Administration (FDA) relies on advisory panels to assist in regulatory decision making regarding medical devices. Public meetings held by these advisory panels allow stakeholders to testify, presenting evidence and recommendations, according to careful procedural standards. This research examines the participation of six stakeholder groups (patients, advocates, physicians, researchers, industry representatives and FDA representatives) in FDA panel meetings focused on the safety of implantable medical devices between 2010–2020. We use qualitative and quantitative methods to analyze speakers’ opportunities for participation, bases of evidence, and recommendations, applying the concept of ‘scripting’ to understand how this participation is shaped by regulatory structures. Regression analysis demonstrates statistically significant differences in speaking time, where researchers, industry, and FDA representatives had longer opening remarks and more exchanges with FDA panelists than patients. Patients, advocates and physicians shared the least amount of speaking time, and were the parties most likely to leverage patients’ embodied knowledge and recommend the most stringent regulatory actions like recalls. Meanwhile, researchers, FDA, and industry representatives rely on scientific evidence and, with physicians, recommend actions that preserve medical technology access and clinical autonomy. This research highlights the scripted nature of public participation and the types of knowledge considered in medical device policymaking.
Elucidating activation and deactivation dynamics of VEGFR-2 transmembrane domain with coarse-grained molecular dynamics simulations
Authors: Go Yeon Ju , Kalathingal Mahroof , Rhee Young Min
Published: February 2023

The vascular endothelial growth factor receptor 2 (VEGFR-2) is a member of receptor tyrosine kinases (RTKs) and is a dimeric membrane protein that functions as a primary regulator of angiogenesis. As is usual with RTKs, spatial alignment of its transmembrane domain (TMD) is essential toward VEGFR-2 activation. Experimentally, the helix rotations within TMD around their own helical axes are known to participate importantly toward the activation process in VEGFR-2, but the detailed dynamics of the interconversion between the active and inactive TMD forms have not been clearly elucidated at the molecular level. Here, we attempt to elucidate the process by using coarse grained (CG) molecular dynamics (MD) simulations. We observe that inactive dimeric TMD in separation is structurally stable over tens of microseconds, suggesting that TMD itself is passive and does not allow spontaneous signaling of VEGFR-2. By starting from the active conformation, we reveal the mechanism of TMD inactivation through analyzing the CG MD trajectories. We observe that interconversions between a left-handed overlay and a right-handed one are essential for the process of going from an active TMD structure to the inactive form. In addition, our simulations find that the helices can rotate properly when the overlaying structure of the helices interconverts and when the crossing angle of the two helices changes by larger than ~40 degrees. As the activation right after the ligand attachment on VEGFR-2 will take place in the reverse manner of this inactivation process, these structural aspects will also appear importantly for the activation process. The rather large change in helix configuration for activation also explains why VEGFR-2 rarely self-activate and how the activating ligand structurally drive the whole VEGFR-2. This mechanism of TMD activation / inactivation within VEGFR-2 may help in further understanding the overall activation processes of other RTKs.
Setting method of exit advance guide signs in mountainous expressway tunnel based on information quantization theory
Authors: Shang Ting , Wu Yifei , Wu Peng , He Hucheng , You Bao
Published: February 2023

Driving behavior in expressway tunnels is more complicated than in common roadbed sections because of differences in illuminance, visual range, speed perception, and reaction time. To explore the setting method of exit advance guide signs in expressway tunnels and improve the effectiveness of drivers’ recognition of them, we propose 12 layout forms based on information quantification theory. In experiments, UC-win/Road was used to build a simulation scene, and the recognition reaction time of 12 element combinations of exit advance guide signs of different subjects was collected through an E-Prime simulation experiment. The loading effectiveness of the signs was analyzed based on the subjective workload and comprehensive evaluation scores of different subjects. The results are the following. The width of the exit advance guide sign layout in the tunnel is negatively correlated with the height of Chinese characters and the distance between the characters and the edge of the sign. The larger the height of Chinese characters and the distance between them and the edge of the sign, the smaller the maximum layout width of the sign. Considering the driver’s reaction time, subjective workload, sign recognition, amount of sign information, sign accuracy, and sign safety of 12 different information combinations, we suggest that exit advance guide signs in tunnels should be laid out as Chinese/English place name + distance + guide arrow.
IL-17A regulates autophagy and promotes osteoclast differentiation through the ERK/mTOR/Beclin1 pathway
Authors: Tang Hao , Zhu Shida , Chen Kai , Yuan Shujie , Hu Junzu , Wang Hongkai
Published: February 2023

Bone is a frequent target of tumor metastasis, with high incidence rate and poor prognosis. Osteoclasts play a key role in the process of tumor bone metastasis. Interleukin-17A (IL-17A) is an inflammatory cytokine, highly expressed in a variety of tumor cells, that can alter the autophagic activity of other cells, thereby causing corresponding lesions. Previous studies have shown that low concentration IL-17A can promote osteoclastogenesis. The aim of this study was to clarify the mechanism of low concentration IL-17A promoting osteoclastogenesis by regulating autophagic activity. The results of our study showed that IL-17A could promote the differentiation of osteoclast precursors (OCPs) into osteoclasts in the presence of RANKL, and increase the mRNA levels of osteoclast-specific genes. Moreover, IL-17A increased the expression of Beclin1 by inhibiting the phosphorylation of ERK and mTOR, leading to enhanced autophagy of OCPs, accompanied by decreased OCP apoptosis. Furthermore, knockdown of Beclin1 and suppression of autophagy by 3-methyladenine (3-MA) significantly attenuated the enhanced osteoclastogenesis induced by IL-17A. In summary, these results indicate that low concentration IL-17A enhances the autophagic activity of OCPs through the ERK/mTOR/Beclin1 pathway during osteoclastogenesis, and further promotes osteoclast differentiation, suggesting that IL-17A may serve as a potential therapeutic target for cancer-related bone resorption in cancer patients.
A precise TIN clipping algorithm for the digital mining design of the opencast coal mine
Authors: Zhao Jingchang , Wang Xiangbo , Wang Dong , Liu Guangwei
Published: February 2023

The triangulated irregular network (TIN) clipping algorithm is one of the vital algorithms for the digital mining design of opencast coal mines based on the geological digital elevation model (DEM) described by TIN. This paper gives a precise TIN clipping algorithm applied in the digital mining design of the opencast coal mine. To improve the algorithm’s efficiency, a spatial grid index is built and utilized to embed the Clipping Polygon (CP) into the Clipped TIN (CTIN) by interpolating the CP’s vertices’ elevation and solving the intersections of the CP and the CTIN. After that, the topology of the triangles situated within (outside of) the CP is reconstructed, and then the boundary polygon of those triangles is obtained based on the reconstructed topology. Finally, a new boundary TIN between the CP and the boundary polygon of the triangles situated within (outside of) the CP is generated by applying the one-time edge-prior constrained Delaunay triangulation (CDT) growth algorithm, and the TIN to be clipped out is separated from the CTIN by topology modification. At that point, CTIN clipping is accomplished with the local details remaining. The algorithm has been programmed in C# and.NET. Additionally, it is also applied to the opencast coal mine digital mining design practice, and it is robust and highly efficient.
Immunopathological mechanisms in the early stage of Mycobacterium avium subsp. paratuberculosis infection via different administration routes in a murine model
Authors: Lee Jun Ho , Park Hong-Tae , Shim Soojin , Kim Suji , Woo Sang-Ho , Kim Dae-Yong , Yoo Han Sang
Published: February 2023

Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease, a chronic emaciating disease of ruminants that causes enormous economic losses to the bovine industry, globally. However, there are still remaining clues to be solved in the pathogenesis and diagnosis of the disease. Therefore, an in vivo murine experimental model was tried to understand responses in early stage of MAP infection by oral and intraperitoneal (IP) routes. In the MAP infection size, and weight of spleen and liver were increased in the IP group compared with oral groups. Severe histopathological changes were also observed in the spleen and liver of IP infected mice at 12 weeks post-infection (PI). Acid-fast bacterial burden in the organs was closely related to histopathological lesions. In the cytokine production from splenocytes of MAP-infected mice, higher amounts of in TNF-α, IL-10, and IFN-γ were produced at early stage of IP-infected mice while IL-17 production was different at time and infected groups. This phenomenon may indicate the immune shift from Th1 to Th17 through the time course of MAP infection. Systemic and local responses in the MAP-infection were analyzed by using transcriptomic analysis in the spleens and mesenteric lymph nodes (MLN). Based on the analysis of biological processes at 6 weeks PI in spleen and MLN in each infection group, canonical pathways were analyzed with ingenuity pathway analysis in the immune responses and metabolism especially lipid metabolism. Infected host cells with MAP increased in the production of proinflammatory cytokines and reduced the availability of glucose at early stage of infection (p < 0.05). Also, host cells secreted cholesterol through cholesterol efflux to disturb energy source of MAP. These results reveal immunopathological and metabolic responses in the early stage of MAP infection through the development of a murine model.
Sex differences in diabetic foot ulcer severity and outcome in Belgium
Authors: Vanherwegen An-Sofie , Lauwers Patrick , Lavens Astrid , Doggen Kris , Dirinck Eveline ,   on behalf of the Initiative for Quality Improvement and Epidemiology in multidisciplinary Diabetic Foot Clinics (IQED-Foot) Study Group
Published: February 2023

Background

Sex differences are increasingly recognized to play an important role in the epidemiology, treatment and outcomes of many diseases. This study aims to describe differences between sexes in patient characteristics, ulcer severity and outcome after 6 months in individuals with a diabetic foot ulcer (DFU).

Methods

A total of 1,771 patients with moderate to severe DFU participated in a national prospective, multicenter cohort study. Data were collected on demographics, medical history, current DFU and outcome. For data analysis, a Generalized Estimating Equation model and an adjusted Cox proportional hazards regression were used.

Results

The vast majority of patients included were male (72%). Ulcers in men were deeper, more frequently displaying probe to bone, and more frequently deeply infected. Twice as many men presented with systemic infection as women. Men demonstrated a higher prevalence of previous lower limb revascularization, while women presented more frequently with renal insufficiency. Smoking was more common in men than in women. No differences in presentation delay were observed. In the Cox regression analysis, women had a 26% higher chance of healing without major amputation as a first event (hazard ratio 1.258 (95% confidence interval 1.048–1.509)).

Conclusions

Men presented with more severe DFU than women, although no increase in presentation delay was observed. Moreover, female sex was significantly associated with a higher probability of ulcer healing as a first event. Among many possible contributing factors, a worse vascular state associated with a higher rate of (previous) smoking in men stands out.
Using a data-driven approach for the development and evaluation of phenotype algorithms for systemic lupus erythematosus
Authors: Swerdel Joel N. , Ramcharran Darmendra , Hardin Jill
Published: February 2023

Background

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown origin. The objective of this research was to develop phenotype algorithms for SLE suitable for use in epidemiological studies using empirical evidence from observational databases.

Methods

We used a process for empirically determining and evaluating phenotype algorithms for health conditions to be analyzed in observational research. The process started with a literature search to discover prior algorithms used for SLE. We then used a set of Observational Health Data Sciences and Informatics (OHDSI) open-source tools to refine and validate the algorithms. These included tools to discover codes for SLE that may have been missed in prior studies and to determine possible low specificity and index date misclassification in algorithms for correction.

Results

We developed four algorithms using our process: two algorithms for prevalent SLE and two for incident SLE. The algorithms for both incident and prevalent cases are comprised of a more specific version and a more sensitive version. Each of the algorithms corrects for possible index date misclassification. After validation, we found the highest positive predictive value estimate for the prevalent, specific algorithm (89%). The highest sensitivity estimate was found for the sensitive, prevalent algorithm (77%).

Conclusion

We developed phenotype algorithms for SLE using a data-driven approach. The four final algorithms may be used directly in observational studies. The validation of these algorithms provides researchers an added measure of confidence that the algorithms are selecting subjects correctly and allows for the application of quantitative bias analysis.
Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy
Authors: Luo Yuening , Sakamoto Kazuichi
Published: February 2023

Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a pyruvic acid derivative, on 6-hydroxydopamine-induced SH-SY5Y cell apoptosis. Ethyl pyruvate decreased protein levels of cleaved caspase-3, phosphorylated endoplasmic reticulum kinase (pERK), and extracellular signal-regulated kinase (ERK), suggesting that EP reduces apoptosis via the ERK signaling pathway. Ethyl pyruvate also decreased oxygen species (ROS) and neuromelanin contents, suggesting that it suppresses ROS-mediated neuromelanin synthesis. Furthermore, increased protein levels of Beclin-1 and LC-II, and LC-II:LC-I ratios indicated that EP upregulates autophagy.
Nursing Student's Experience of Class in COVID-19 New Infectious Disease Crisis Situation: A Qualitative Content Analysis
Authors:   Crisis and Emergency Management: Theory and Praxis, Kim Nam-Hee
Published: February 2023

Purpose: This study was conducted to analyze the class experiences of nursing students in the COVID-19 new infectious disease crisis situation to increase understanding of non-face-to-face(NFTF) classes. Methods: This study was conducted on 108 nursing students who participated in NFTF classes and submitted reflection journals at the department of nursing located in Busan from July 1 to July 15, 2022. As for the data analysis method, qualitative content analysis was conducted. Result: The three categories were positive aspects of NFTF classes, negative aspects of NFTF classes, and experiences of mixed classes. The 10 subcategories are the comfort of NFTF classes, repetitive viewing of lectures, flexible use of time, no inconvenience in commuting, difficulty in concentrating, stuffy and uncomfortable, communication problems, deterioration in class quality, confusion and discomfort during mixed classes. Conclusion: In the future, it seems necessary to develop a teaching method that can be approached from a holistic point of view without distinguishing between face-to-face(FTF) and NFTF classes.
Measuring potential tax non-compliance in the Indonesian tax system: A meta-analysis
Authors: Probowulan Diyah , Zulkarnnaeni Achmad Syahfrudin
Published: February 2023

This study aims to assess, firstly, the potential for taxpayers' non-compliance from previous studies that are dominant between tax avoidance and tax evasion due to active resistance in the taxation system in Indonesia. Secondly, it also tries to assess and parse the ability of the taxation system in Indonesia to prevent taxpayers from being disobedient. This study used a meta-analysis for the data analysis with the moderating variable regression equation of the taxation system. The results show that high tax sanctions and stable financial conditions can minimize the potential for tax non-compliance, while the quality of tax services, compliance costs, and tax socialization from 12 study samples have not been able to be used as factors to reduce the potential for tax non-compliance. This study also identifies the tendency of tax non-compliance behavior to be dominated by tax evasion. The originality of this study lies in using the meta-analysis method and using a dummy on the dependent variable to see the potential for non-compliance between tax avoidance and tax evasion. The implications of this study provide important insights for policymakers and government leaders in designing fiscal policies to minimize the social phenomena of tax non-compliance and build a tax compliance mindset and also redesign a tax system that is more credible, easy to understand, and prevents loopholes a system that the taxpayer can utilize.
Separability and the 3d Gelfand Levitan equation
Authors: Kincanon Eric
Published: February 2023

The 1D Gelfand-Levitan equation has been well studied with respect to the separability of the spectral measure function. The analytic solu-tion has been shown to be associated with reflectionless potentials. This paper considers the 3D version of this equation to see if an analytic solution can be found for a separable spectral measure function and if it also corresponds to known reflectionless potentials. Though the analytic solution is shown, it does not correspond to reflectionless potentials.Â Â
Modeling environmental tree species’ volume using some selected skewed distributions
Authors: A. Hassan F. , O. Ilo H. , O. Afolabi N. , A. Akintola K.
Published: February 2023

Ecological requirements' knowledge in determining tree species' distributions is a precondition for sustainable forest management. Tree species in all regions are threatened by climate change but some are more vulnerable than others. Rightly skewed distributions were used to take care of the environmental data set obtained from FRIN using five species which are: Beech Wood, White Afara, Opepe, Afon and Teak.Appropriate statistical tools distributions like descriptive analysis, Akaike Information Criterion (AIC), Goodness of Fit, Probability Functions, Kolmogorov Smirnovt-test, Gamma, Weibull, Log-normal and Beta-weibull were carried out to determine the best distribution for each selected specie in this research.It was established from the distributional pattern of the tree species' volume used in this research that the Gamma distribution was a better fit for the Beech wood with the AIC of 617.21, Beta-weibull distribution was a better _t for the White Afara, Opepe and Teak Species with the AIC values of 580.772, 630.84 and 733.60 respectively while the Weibull distribution was a better fit for the Afon specie with the AIC value of 752.07.Conclusively, the implication of the analysis is that the Beta-weibull distribution described the tree species' volume best among the four distributions used. In line with the findings, it is recommended that Beta-weibull should be the appropriate distribution to model forest specie when it comes to modelling because of its four (4) parameters and its goodness when fitting.Â Â Â
Investigation of properties of soils stabilised with groundnut waste
Authors: O. Adunoye G. , O. Osineye T. , C. Ezeh H.
Published: February 2023

Improvement of soil strength has gained a wider and increasing acceptance in civil engineering applications. This study therefore investigat-ed the effects of coarse content of groundnut shell ash on the properties of selected lateritic soils. To achieve the aim of the study, soil sam-ples were collected from two identified active borrow pits. The following geotechnical tests were conducted on the soil samples in their natural state, using standard procedures: natural moisture content, specific gravity, grain size analysis, Atterberg limits, compaction and California bearing ratio. Subsequently, the soils were treated with coarse content (part retained on 425 Âµm BS sieve) of groundnut shell ash at 2 %, 4 % and 6 % proportions by weight of dry soil. Results showed that the degree of laterisation is high in the two soil samples, having specific gravity values of 2.84 and 2.72 respectively. Results of Atterberg limit tests and grain size analysis showed that the soils belong to A-2-7 using AASHTO classification system. 6 % groundnut shell ash gave the lowest plasticity index for first sample, while 2 % ground-nut shell ash gave the lowest plasticity index for second sample. Also, 2 % groundnut shell ash gave the lowest optimum moisture content for first sample, while 6 % groundnut shell ash gave the lowest optimum moisture content for the second sample. Similarly, 2 % groundnut shell ash gave the highest maximum dry density for first sample, while 4 % groundnut shell ash gave the highest maximum dry density for second sample The California bearing ratio reached a maximum value of 4 % at 6 % groundnut shell ash, for first sample; it increased to 14 % at 2 % groundnut shell ash, for second soil sample. The study concluded that lateritic soils can be modified with coarse component of groundnut shell ash.Â Â
Atomistic study of stability and new phase transitions of zinc selenide using FP-LMTO-PLW method
Authors: Hamza REKAB DJABRI , Salah DAOUD , Youcef GUERMIT , Nabil BELOUFA , Souad LOUHIBI FASLA
Published: February 2023

By full potential linear muffin-tin orbitals (FP-LMTO-PLW) method, we have studied the phase transitions of ZnSe under high pressures. The local density approximation (LDA) was used for the exchange and correlation energy. The most important result is the prediction of the possibility of four phase transitions from the cubic zincblende (ZnS-B3) to the B81 (NiAs) structure at 8.00 GPa, the second from B3 to the B32 (NaTi) and Bh (WC) structures at above 45 GPa for each one of them, and from B3 to B2 (CsCl) phase at around 31GPa. The first one (ZnSâ€“NiAs) occurring at a lower pressure than the well knownZnS to NaCl transition (found here to be 11.5 GPa).
Analysis of variation of water quality parameters along treatment processes in OPA waterworks, ILE-IFE, Nigeria
Authors: O. Jeje J. , O. Fadipe O. , T. Oladepo K.
Published: February 2023

This study was conducted to assess the variation of water quality parameters along the treatment processes of Opa Waterworks at Obafemi Awolowo University, Ile â€“ Ife, Nigeria. This was to ascertain how chemical and physical parameters vary along the treatment plant visits while at the same time ensuring that the influent and effluent conforms to water quality standards set by the World Health Organization.Determination of physicochemical parameters; pH, temperature, conductivity, turbidity, nitrate and chloride was done by Â using standard methods while a colorimetric, Â and atomic absorption spectrometry methods were used for the selected heavy metals; cadmium, zinc and copper.It was observed that for the influent, the concentration of lead was 9.44 mg/l, nitrate 0.25 mg/l, chloride 18.27 mg/l, sulphate 4.29 mg/l, copper 4.55 mg/l, zinc 0.07 mg/l and cadmium 1.10 mg/l. For the effluent, the concentration of nitrate was 0.22 mg/l, chloride 16.01 mg/l and sulphate 4.29 mg/l while that of lead, copper, zinc and cadmium was 0.00 mg/l. The overall results show that the concentrations of the water quality parameters tested conform to the World Health Organization water quality standards at the effluent points of the treatment plant.Â Â
The discovery and importance of the higgs boson
Authors: Pereira da Silva Jizreel
Published: February 2023

This work presents the importance of the existence of the Higgs boson, a particle with a mechanism capable of generating mass for other elementary particles, where interacting particles receive mass and those that do not interact, do not receive mass. The work shows the understanding of the mechanism for the interactions of particles with the Higgs boson and analysis of the experiments carried out at CERN, together with other detectors such as CMS and ATLAS, in the search over 50 years for the physicist Peter Higgs, suggesting a new theory necessary for the existence of the mechanism that would generate mass for the other particles. Even with the scientific advance through the discovery of the Higgs boson and its explanation within the Standard Model, we still have questions to be answered by not explaining gravitational interaction, hierarchy problem, extra dimensions, supersymmetry, dark matter, among others. The discovery and importance of the Higgs boson is another achievement for science, int the sense that we are on the right path, even recognizing the limitations of equipment and investments, but in the search for the truth and answer in favor of a more structured society, such as improved health, living in an environment with less pollution, advancement in technology, resulting in several positive factors for humanity.Â Â
Entrevista com Mario Groisman
Authors: Furlaneto Flávia , Groisman Mario
Published: February 2023

Qual o momento ideal para instalação de implantes em um paciente com histórico de periodontite? Quais as chances de sucesso em curto e longo prazos da terapia com implantes em um paciente periodontal? Quais parâmetros biológicos devem ser considerados na manipulação de tecidos peri-implantares? Essas são algumas das questões da Perio-implantodontia que têm sido amplamente debatidas e investigadas no mundo todo. O que não temos dúvidas é que é cada vez mais evidente a necessidade de vasto conhecimento da literatura periodontal para a tomada de decisões baseadas em evidências na prática clínica com reabilitação por implantes osseointegrados. Na coluna desta edição, tivemos a oportunidade de entrevistar um pioneiro no estudo da Periodontia associada à Implantodontia no Brasil, o Prof. Mario Groisman. O Professor Mario Groisman é especialista em Periodontia e Mestre em Ciências Dentais pela Faculdade de Odontologia da Universidade de Lund, Malmo, Suécia. Há mais de 30 anos, o Professor Mario Groisman, munido sempre de raciocínio rápido, leveza e cordialidade em suas apresentações, vem compartilhando sua experiência clínica em vários cursos ministrados no Brasil e no exterior. Ex-presidente da Academia Brasileira de Odontologia, o Professor Mario Groisman publicou mais de 40 artigos científicos na literatura especializada e é uma grande referência de profícuo conhecimento científico associado a uma vasta experiência clínica na Perio-Implantodontia.
Prevalência e aspectos imunológicos da associação entre a Doença Periodontal e a Doença Inflamatória Intestinal – revisão narrativa da literatura
Authors: Prado Natália Araújo Silva , Fischer Ricardo Guimarães
Published: February 2023

INTRODUÇÃO: Algumas semelhanças são observadas entre a doença inflamatória intestinal e a doença periodontal. Ambas são definidas como doenças inflamatórias crônicas e são influenciadas pela resposta imune e inflamatória do indivíduo. O microbioma e os processos inflamatórios imunomediados possuem um papel importante nas duas doenças e as duas apresentam um impacto sistêmico. OBJETIVO: O objetivo do presente estudo foi realizar uma revisão de literatura sobre doença periodontal e a doença inflamatória intestinal e sobre a prevalência e os aspectos imunológicos da associação entre elas. MATERIAL E MÉTODOS: Foi realizada uma revisão narrativa da literatura baseada em artigos selecionados na base de dados PubMed, publicados de 1989 à 2019, utilizando as palavras-chave "inflammatory bowel disease" e "periodontal disease", e o operador Booleano "AND". RESULTADOS: Após ajustados os critérios de inclusão e exclusão, 11 artigos foram selecionados para serem discutidos. CONCLUSÃO: Conclui-se que há uma maior prevalência de periodontite em pacientes com doença inflamatória intestinal e que é possível que haja uma interação complexa entre a periodontite e a doença inflamatória intestinal, sendo que uma doença pode influenciar no aumento da resposta inflamatória do hospedeiro da outra. No entanto, mais estudos são necessários para melhor explicar essa relação. É importante que dentistas e gastroenterologistas tenham o conhecimento da possível relação entre a doença periodontal e a doença inflamatória intestinal e que eduquem seus pacientes em relação ao risco de periodontite e a importância dos métodos de higiene bucal.
Implantoplastia associada a membranas de fibrina rica em plaquetas para o tratamento de peri-implantite: um relato de caso
Authors: Miguel Manuela Maria Viana , Santamaria Ingrid Fernandes Mathias , Santamaria Mauro Pedrine
Published: February 2023

OBJETIVO: A peri-implantite é uma doença biofi lme-dependente que afeta os tecidos ao redor do implante dentário, caracterizando-se por infl amação da mucosa peri-implantar e perda óssea progressiva. A fi brina rica em plaquetas é conhecida pelas propriedades de acelerar o processo de cicatrização de feridas e atividade antimicrobiana. Estudos vêm sendo realizados com a aplicação de fi brina rica em plaquetas no campo da implantodontia. No entanto, existem poucas evidências sobre os benefícios no tratamento da peri-implantite. MATERIAL E MÉTODOS: O presente relato de caso descreve o tratamento de defeitos de peri-implantite no segundo quadrante (região de incisivo lateral e canino) na prótese parcial fi xa implantossuportada de uma paciente de 59 anos de idade. O diagnóstico foi baseado na profundidade de sondagem (PS) > 6 mm e nível de perda óssea (NPO) de 5 e 3 mm nas regiões de incisivo lateral e canino. Além disso, uma deiscência em tecido mole vestibular de 1,5 e 3 mm foi observada nas regiões de incisivo lateral e canino, respectivamente. Foi realizada cirurgia a retalho para descontaminação da superfície do implante por meio de implantoplastia associada a membranas de fi brina rica em plaquetas, seguido de medicação antimicrobiana adjuvante por sete dias. RESULTADOS: Uma melhora clínica relevante foi observada em relação à profundidade de sondagem (< 4 mm) após quatro meses. Além disso, nenhum sangramento e supuração à sondagem foram observados. O ganho médio de largura da mucosa queratinizada foi de 1,1 mm após quatro meses de acompanhamento. Em adição, a margem vestibular da mucosa peri-implantar apresentou mínima recessão (0,5 mm cada) após o procedimento cirúrgico. A largura da mucosa queratinizada também aumentou ao fi m do acompanhamento. CONCLUSÃO: A cirurgia a retalho para descontaminação da superfície do implante por meio de implantoplastia associada a membranas de fi brina rica em plaquetas apresentou bons resultados clínicos no tratamento da peri-implantite.
Biological variation estimates for spot urine analytes and analyte/creatinine ratios in 33 healthy subjects
Authors: Yılmaz Çalık Gizem , Şeneş Mehmet
Published: February 2023

Objectives

Urine samples are frequently used in the clinical practice. In our study, we aimed to calculate the biological variations (BV) of analytes and analyte/creatinine ratios measured in spot urine.

Methods

Second-morning spot urine samples were collected from 33 (16 female, 17 male) healthy volunteers once weekly for 10 weeks and analyzed in the Roche Cobas 6,000 instrument. Statistical analyzes were performed using BioVar, an online BV calculation software. The data were evaluated in terms of normality, outliers, steady state, homogeneity of the data, and BV values were obtained by analysis of variance (ANOVA). A strict protocol was established for within-subject (CVI) and between-subject (CVG) estimates for both genders.

Results

There was a significant difference between female/male CVI estimates of all analytes except potassium, calcium and magnesium. No difference was found in CVG estimates. When the analytes that had a significant difference in CVI estimates in spot urine analytes were compared to creatinine, it was observed that the significant difference between the genders disappeared. There was no significant difference between female/male CVI and CVG estimates in all spot urine analyte/creatinine ratios.

Conclusions

Since the CVI estimates of analyte/creatinine ratios are lower, it would be more reasonable to use them in result reporting. Reference ranges should be used with caution, since II values of almost all parameters are between 0.6 and 1.4. The CVI detection power of our study is 1, which is the highest value.
Sustainable high-strength lightweight concrete with pumice stone and sugar molasses
Authors: Mohammed Tamara Amer , Kadhim Hayder Mohammed
Published: February 2023

The building sector benefits from high-strength lightweight concrete (HSLWC) in various aspects, particularly in reducing the structure’s dead load. Incorporating waste materials into HSLWC encourages sustainable practices, reduces their environmental effect, and decreases product’s costs. This research focuses on producing sustainable HSLWC using a pumice stone and additive materials such as sugar molasses, silica fume, and high-range water reduction. The physical and mechanical properties and structural efficiency were investigated. The results demonstrate that the inclusion of additive material is the primary factor controlling the properties of the concrete. Also, using pumice stone instead of gravel in high-strength concrete significantly reduced weight and increased thermal insulation by 19.31 and 43.55%, respectively. Furthermore, the addition of steel fibers in HSLWC improved the compressive strength, tensile strength, ductility, and structural efficiency.
circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway
Authors: Sun Changpeng , Guan Hongjun , Li Jinjin , Gu Yinfeng
Published: February 2023

Non-small cell lung cancer (NSCLC) accounts for 80% of total lung cancers, which are the main killer of cancer-related death worldwide. Circular RNA (circRNA) has been found to modulate NSCLC development. However, the role of circ_0000376 in NSCLC development has been underreported. The present work showed that circ_0000376 and 3-phos-phoinositide-dependent protein kinase-1 (PDPK1) expression were dramatically increased, but miR-545-3p was decreased in NSCLC tissues and cells. circ_0000376 expression was closely associated with lymph node metastasis, tumor-node-metastasis stage, and tumor size of NSCLC patients. circ_0000376 knockdown repressed NSCLC cell proliferation, migration, invasion, and glutaminolysis but induced cell apoptosis. Additionally, miR-545-3p bound to circ_0000376, and circ_0000376 regulated cell phenotypes by associating with miR-545-3p. MiR-545-3p also participated in NSCLC cell proliferation, migration, invasion, apoptosis, and glutaminolysis by targeting PDPK1. Further, circ_0000376 absence repressed tumor formation in vivo. Collectively, circ_0000376 regulated NSCLC cell tumor properties by the miR-545-3p/PDPK1 axis, suggesting that circ_0000376 could be employed as a therapeutic target for NSCLC.
A topological duality for dcpos
Authors: Zhang Liping , Zhou Xiangnan
Published: February 2023

In this paper, a Stone-type duality for directed complete posets with a top element is developed by using a class of special subsets, named prime Scott open subsets. Following this idea, a topological duality for complete lattices is also obtained.
Addendum to “A generalization of a result on the sum of element orders of a finite group”
Authors: Lazorec Mihai-Silviu , Tărnăuceanu Marius
Published: February 2023

Let G be a group of order n and H be a subgroup of order m of G. Denote by ψ

H
(G) the sum of element orders relative to H of G. It is known that if G is nilpotent, then

ψ
H

(
G
)
≤

ψ

H
m

(

C
n

)

$ \psi_H(G) \leq\psi_{H_m}(C_n) $

, where H

m
is the unique subgroup of order m of C

n
. In this note, we show that this inequality does not hold for infinitely many finite solvable groups.
The evaluation of the mechanical properties of glass, kenaf, and honeycomb fiber-reinforced composite
Authors: Abidin Nur Marini Zainal , Sultan Mohamed Thariq Hameed , Md Shah Ain Umaira , Shahar Farah Syazwani , Najeeb Muhammad Imran , Ali Mohd Radzi , Basri Adi Azriff , Baloor Satish Shenoy , Gaff Milan , Hui David
Published: February 2023

The development of hybrid composite materials using honeycomb structure, typically a lightweight material, is commonly used in aircraft structures. However, the use of honeycomb with natural or synthetic composite remains unexplored in the literature. Therefore, this study aims to partially replace synthetic fiber, woven glass with a natural fiber of woven kenaf and honeycomb core. An experimental analysis investigated the mechanical strength of three different compositions using glass, kenaf, and honeycomb materials for structural application purposes. The properties of the sample were evaluated through the tensile, flexural, and impact strength, and the morphological damage was observed using scanning electron microscopy. The results showed that the composition of GKGKG laminate composite is the highest in tensile strength (147.64 MPa) and modulus (3.9 GPa), while the GKHKG composite was good in flexural strength (219.03 MPa) and modulus (11.47 GPa). In terms of impact properties, there was a slight difference in energy level (20–30 J) by GKGKG and GKHKG, showing the optimal hybrid configuration of composite for the newly developed material. In conclusion, the application of the new hybrid of GKHKG composite is promising in semi-structural and structural light-weight applications.
Progress of sensitive materials in chemiresistive sensors for detecting chemical warfare agent simulants: A review
Authors: Yang Liu , Qin Molin , Zhang Genwei , Yang Jie , Yang Junchao , Zhao Jiang
Published: February 2023

Chemical warfare agents (CWAs) are chemical substances intended for use in military operations to kill, injure, or incapacitate an enemy. It is very important to detect toxic CWAs at trace levels on site. Compared with traditional CWA analysis instrument methods, chemiresistive gas sensors present advantages of being small, fast, and inexpensive. Chemiresistive gas sensors are still an important research topic with the development of nanofabrication technology and new kinds of sensing materials, including carbon nanotubes, graphene, and black phosphorus (BP). Chemiresistive gas sensors are divided into three categories according to the type of sensitive materials: carbon- and BP-based materials, conductive polymers, and metal oxide semiconductors. A brief analysis was carried out on fabrication strategies using sensitive materials, including hydrogen bonding strategies, nanostructures, morphology, doping effects, composite materials, and other material application methods, and the sensitive materials and detection effects are summarized in this study. This review aims to provide guidance in the development of chemiresistive sensors for the detection of CWAs.
Growing axons: greedy learning of neural networks with application to function approximation
Authors: Fokina Daria , Oseledets Ivan
Published: February 2023

We propose a new method for learning deep neural network models, which is based on a greedy learning approach: we add one basis function at a time, and a new basis function is generated as a non-linear activation function applied to a linear combination of the previous basis functions. Such a method (growing deep neural network by one neuron at a time) allows us to compute much more accurate approximants for several model problems in function approximation.
An Early Neolithic enclosure at the site of Vlaho, Pelagonia
Authors: Naumov Goce , Przybyła Marcin , Gibaja Juan F. , Penezić Kristina , Antolín Ferran , Sabanov Amalia , Fidanoska Aneta
Published: February 2023

Recent study of Vlaho in Pelagonia confirms that it is the earliest known Neolithic settlement in North Macedonia. Multidisciplinary research of the architecture and material reveals a complex enclosure site dating to the seventh millennium BC, with dozens of ditches, daub buildings, white painted pottery and domesticated plants and animals.
Quantifying the Workability of Cold In-Place Recycling in the Laboratory
Authors: Williams Archie Gus , Braham Andrew F. , Casillas Sadie
Published: February 2023

The Dongre Workability Test (DWT) is a method for determining an asphalt pavement’s relative workability based on stress–strain relationships during compaction in a Superpave gyratory compactor. Although the DWT has seen favorable results with warm-mix and hot-mix asphalt, there has been limited attempts to apply it to cold-mix asphalt (CMA), and those limited attempts did not provide conclusive results. This research re-examined the curves developed during the DWT data collection in order to better quantify the workability of CMA, specifically, cold in-place recycling (CIR). Phase one consisted of defining ten possible metrics from the stress–strain curve and applying them to samples with three different curing conditions. From these preliminary results, the five metrics that showed the greatest differences between curing conditions with small relative coefficients of variation were chosen for continued evaluation. In phase two, these five metrics were applied to three different asphalt emulsions at four different curing conditions (temperature-minutes: 10C-30, 10C-120, 60C-30, and 60C-120). Two metrics based on different areas under the stress–strain curve yielded the most logical and consistent results, with higher values indicating a more workable mixture. Samples cured for 30 minutes at either 10°C or 60°C showed the most noticeable distinction between workability of each asphalt emulsion. Moving forward, it is recommended these metrics be applied to additional asphalt emulsions, reclaimed asphalt pavement sources and gradations, and curing conditions to determine if the DWT method can be modified for application to CIR mixtures.
Evaluating the Creep Deformation and Elastic Recovery of Different Polymer-Modified Bitumens Using a New Bitumen Quality Control Test
Authors: Cai Fengjie , Feng Zhen-gang , Chen Tingting , Li Shikai , Wei Jincheng , Li Xinjun
Published: February 2023

To quickly and accurately evaluate the creep deformation and elastic recovery performance of polymer-modified bitumen, a new bitumen quality control test (QCT) was carried out to analyze the creep deformation and recovery properties of styrene-butadiene-styrene (SBS)-modified bitumen and rubber powder–modified bitumen with different modifier dosage at 15°C, 20°C, 25°C, and 30°C. At the same time, the creep deformation speed of different polymer-modified bitumens was also investigated based on the QCT results. Then, the penetration and dynamic shear rheological tests were implemented on these binders to establish the relationship between QCT indexes (maximum creep deformation and deformation recovery rate) and physical–rheological indexes (penetration and complex viscosity). Results show that the creep deformation resistance and elastic recovery ability of bitumen enhance gradually with the increase of both SBS and rubber powder. Between SBS and rubber powder, SBS exhibits a more significant influence on the creep deformation resistance and elastic recovery properties of bitumen than rubber powder under the same temperature and modifier dosage. A polymer-modified bitumen with smaller penetration and bigger complex viscosity is prone to better creep deformation resistance and elastic recovery performance.
On the Role of Theory and Modeling in Neuroscience
Authors: Levenstein Daniel , Alvarez Veronica A. , Amarasingham Asohan , Azab Habiba , Chen Zhe S. , Gerkin Richard C. , Hasenstaub Andrea , Iyer Ramakrishnan , Jolivet Renaud B. , Marzen Sarah , Monaco Joseph D. , Prinz Astrid A. , Quraishi Salma , Santamaria Fidel , Shivkumar Sabyasachi , Singh Matthew F. , Traub Roger , Nadim Farzan , Rotstein Horacio G. , Redish A. David
Published: February 2023

In recent years, the field of neuroscience has gone through rapid experimental advances and a significant increase in the use of quantitative and computational methods. This growth has created a need for clearer analyses of the theory and modeling approaches used in the field. This issue is particularly complex in neuroscience because the field studies phenomena that cross a wide range of scales and often require consideration at varying degrees of abstraction, from precise biophysical interactions to the computations they implement. We argue that a pragmatic perspective of science, in which descriptive, mechanistic, and normative models and theories each play a distinct role in defining and bridging levels of abstraction, will facilitate neuroscientific practice. This analysis leads to methodological suggestions, including selecting a level of abstraction that is appropriate for a given problem, identifying transfer functions to connect models and data, and the use of models themselves as a form of experiment.
A Home Away from Home: The Halfway-Return of Western-Trained Asian Scientists
Authors: Paul Anju M.
Published: February 2023

Return migration is typically framed as migration back to familiar territory. In contrast, onward migration does not presume any type of prior connection that the emigrant has with their new destination. This article proposes a new category of migration—“halfway-return”—that sits between return and onward migrations. Halfway-return refers to an emigrant’s return to the broader geographical region from which they originated, rather than the specific country they were born or raised in. The ideal-typical halfway-return destination is a country that is more geographically proximate and also culturally similar to the emigrant’s birth country, compared to their previous overseas destination. But the halfway-return destination also offers lifestyle and/or career opportunities that are better than what is available in the emigrant’s birth country. In order to theorize the concept of halfway-return, this article draws from interview-based research conducted with thirty-four Asian-born, Western-trained bioscientists who, when they returned to Asia, chose to move to a different Asian country than their birth country. Most were Chinese- and Indian-born scientists who chose to move to Singapore rather than their birth country after spending several years training and working in the West. The concept of halfway-return helps shift the migration studies lexicon away from a methodological nationalism that assumes that an individual’s birth country is the only lens through which to determine what counts as return. It also acknowledges growing regionalization trends in Asia and elsewhere, within more-studied globalization patterns.