bluuebunny/crossref_metadata_2025 huggingface dataset:
Futuristic Hydroclimatic Projections under CMIP6 GCMs: Implications for Water Resources Management
Authors: Haleem Kashif , Khan Afed Ullah , Khan Fayaz Ahmad , Zada Umar , Khan Jehanzeb , Khan Mehran
Published: August 2023

Pakistan is primarily dependent on water supplies from the Upper Indus basin for irrigated agriculture. Any changes in available resources due to climate, consequently has the potential to have a significant impact on the environment. Coupled model inter-comparison project phase 6 (CMIP6) based global climate models (GCMs) under shared socioeconomic pathways (SSP245) scenario were assessed to evaluate the study area for climate change effect on river runoff using Soil and water assessment tool (SWAT). Temperature fluctuations have a significant effect on stream flow, since the primary sources of river runoff in the Upper Regions of Indus Basin (URIB) are snow and glacier melting. The temperature (min & max) will likely increase by almost 18% in the future, the projected precipitation pattern will increase by 13-17 %, and the stream flow will increase by 19-30 % in the future due to the warmer temperature. Temperature (min & max), precipitation and stream flow have had different effects in each season, while their variability in the projected annual changes are increasing for mid and late 21stcentury. Hydroelectricity generation, irrigation, flood prevention, and storage reservoir will be required in the strategies and action plans for the effective water resources management.
Causal Association between Glaucoma and Risk of Retinal Vascular Occlusion: A Mendelian Randomization Study
Authors: Wang Zixun , Li Zhiqing
Published: August 2023

Background
Retinal vein occlusion (RVO) is a common retinal vascular disease that leads to visual impairment. In the elderly, risk factors may include glaucoma. Some studies suggest a correlation between glaucoma and RVO, but it remains unknown if the association is causal. The aim of this study was to perform Mendelian randomization(MR) analyses to evaluate the causal contribution of genetically predicted glaucoma to RVO.
Methods
A two-sample MR analysis using the inverse‐variance weighted (IVW), weighted median and MR‐Egger regression methods was performed. We used the publicly available summary statistics data sets of genome‐wide association studies (GWAS) meta‐analyses for glaucoma in individuals of European descent (n = 351696;133492 cases and 90939 controls) as the exposure and a GWAS for RVO Finn Gen biobank study (n = 204613;1595 cases and 203018 controls) as the outcome. We conducted univariable MR analyses to identify the causal effects of RVO. Although inverse variance weighted (IVW) was the primary method used for MR analyses, MR–Egger and weighted-median methods were used as supplements to IVW. We determined the heterogeneity of IVs using Cochrane’s Q test and I2, and used the MR–Egger intercept and MR-PRESSO Global test to detect horizontal pleiotropy.
Results
Genetically predicted glaucoma was found to be causally associated with RVO risk (beta = 0.267,SE = 0.051, odds ratio (OR) = 1.306, 95% confidence interval (CI): 1.181–1.445, P = 3.26×10− 3). This association was supported by sensitivity analyses using the weighted median (beta = 0.211,SE = 0.074,OR = 1.235, 95% CI: 1.064–1.429,P = 0.112), weighted mode (beta = 0.491,SE = 0.132,OR = 1.633, 95% CI: 1.261–2.116, P = 0.05), and MR-Egger (beta = 0.3900,SE = 0.138,OR = 1.476, 95% CI: 1.128–1.933, P = 6.237×10− 2) methods. The MR analyses using the validation dataset obtained consistent results.
Conclusion
The results of MR analysis support that glaucoma may be causally associated with an increased risk of RVO. Furthermore, this is the first study to discuss the causal relationship between glaucoma and RVO at the genetic level. Future studies are required to elucidate the underlying mechanisms.
Effects of machining gap on the surface integrity in CBN spherical magnetic abrasives grinding of ZrO2 ceramic
Authors: Jiang Linzhi , Chang Tieyan , Zhang Guixiang , Chen Yu-Sheng , Liu Xue , Zhang Haozhe
Published: August 2023

Due to the high hardness and brittleness of zirconia ceramic (ZrO2), it is difficult to generate a good surface integrity by traditional grinding. The surface quality of ZrO2 can be greatly improved by magnetic abrasive finishing (MAF) with spherical CBN/Fe-based magnetic abrasive particles (MAPs) prepared by gas atomization. In this study, it was found that the difference of machining gap in MAF would seriously affect the surface integrity of ZrO2. The grinding pressure of CBN MAPs on ZrO2 under different machining gaps was analyzed theoretically. The surface morphology, surface roughness Ra and material removal amount MR, grinding pressure, surface temperature and residual stress, subsurface damage and the morphology of MAPs adsorbed by magnetic pole after grinding were studied under different machining gaps (3 mm to 1 mm). The results show that when the machining gap is large, the grinding pressure is small, the number of MAPs involved in grinding is small, and the surface integrity of ZrO2 do not change significantly. When the machining gap is small and the grinding pressure is too large, a large number of MAPs are extruded from the machining area, the magnetic abrasive brush is changed from flexible to rigid, and the ceramic surface is mainly removed by brittleness. After grinding, many cracks and pits are generated on the ceramic surface, and cracks are also produced on the subsurface, which destroys the surface integrity of the workpiece. Under the appropriate machining gap, it can not only ensure that the grinding pressure is large, but also make the ZrO2 surface mainly plastic removal, and finally obtain the best surface integrity.
The Effects of Dietary patterns on Hedonic Hunger in University Students
Authors: Ulker İzzet , Camli Ayşe , Pourdeh Elham Foroudi , Aksu Zeynep
Published: August 2023

This study was conducted to examine the effect of the Dietary patterns on hedonic hunger. This descriptive, cross-sectional study included 617 university students. The Study data was obtained through a web-based survey form. The survey form includes individuals’ socio-demographic characteristics, anthropometric measurements, Mediterranean Diet Quality Scale (KIDMED), Mediterranean Diet Adherence Scale (MEDAS), and Power of Food Scale (PFS). 503 women and 114 men have participated in the study. The sub-scale score average for food availability in Overweight/obese individuals was found to be significantly higher than that of underweight individuals (p < 0.05). A statistically significant negative correlation was observed at a low level between MEDAS scores and PFS total scores (r=-0.081, p = 0.045), as well as with food availability (r=-0.111, p = 0.006), and food presentation (r=-0.088, p = 0.028). However, no statistically significant relationship was found between food tasting sub-scale scores (p > 0.05). The results of this study reveal the existence of a low level of negative correlation between hedonic hunger and adherence to the Mediterranean diet. Further extensive research is needed concerning individuals residing in diverse geographic locations to gain deeper insights into this subject matter.
Detection of mecA gene from methicillin-resistant Staphylococcus aureus isolated from school children, Kathmandu, Nepal
Authors: Bhandari Bina , Ansari Mehraj , pyakurel Susil , Rijal Sandeep , Sah Anil Kumar , Aryal Manita
Published: August 2023

Staphylococcus aureus (S. aureus) is an important pathogen affecting children worldwide. Children are at increased risk of nasal colonization and may be responsible for spreading S. aureus and methicillin-resistant S. aureus (MRSA) to the community settings. This study aimed to determine MRSA nasal colonization among school-going (aged 10–16 years) children of Kathmandu Valley and detect the mecA gene among isolated S. aureus. This study is the first study from Nepal to test the mecA gene from S. aureus from the community (school children). A total of 190 samples were collected from anterior nares, and S. aureus was identified using standard microbiological techniques. An antibiotic susceptibility test was performed, and MRSA screening was done by incorporating the cefoxitin disk in the AST plate. DNA was extracted using the hexadecyltrimethylammonium bromide (CTAB) method, and the mecA gene was detected using PCR. Statistical analysis was carried out using SPSS v16.0. Among the total of 190 children, 85 (44.7%) had nasal S. aureus colonization, and 45 (53%) were positive for MRSA. The highest MRSA colonization (100%) was found in females aged 10–12 years. Age and handshaking habits were associated risk factors of nasal MRSA colonization. Gentamycin, linezolid, and vancomycin were highly effective against MRSA, and erythromycin was the least effective besides cefoxitin and penicillin. Similarly, among 45 MRSA isolates, 41 (91.1%) were mecA gene-positive, and among 40 MSSA isolates, 38 (95%) were mecA gene positive. Our study showed a high prevalence of MRSA among school children. The prevalence of the mecA gene among MRSA isolates was also high. Therefore, the proper screening of MRSA should be done to identify, decolonize carriers and prevent the possible spread of MRSA to students in school and even to the community.
Association between iron status markers and kidney outcome in patients with chronic kidney disease
Authors: Fujisawa Hironobu , Nakayama Masaru , Haruyama Naoki , Fukui Akiko , Yoshitomi Ryota , Tsuruya Kazuhiko , Nakano Toshiaki , Kitazono Takanari
Published: August 2023

The associations of iron status markers such as transferrin saturation (TSAT) and serum ferritin with kidney outcome in patients with chronic kidney disease (CKD) were inconsistent and remained strongly debated. Therefore, we aimed to investigate whether TSAT and serum ferritin levels were associated with kidney outcome in such a population. In this prospective study, primary kidney outcome was a composite of doubling of serum creatinine, end-stage kidney disease, or death due to kidney failure. Participants were divided into quartiles (Q1–Q4) according to TSAT or serum ferritin levels. In the multivariable Cox analyses, compared with Q3 of TSAT, the hazard ratios (95% confidence intervals) for Q1, Q2, and Q4 were 1.22 (0.89, 1.69), 1.40 (1.03, 1.89), and 1.15 (0.82, 1.60), respectively. Compared with Q2 of serum ferritin, lower and higher quartiles had a significantly increased risk for kidney outcome; hazard ratios (95% confidence intervals) for Q1, Q3, and Q4 were 1.65 (1.19, 2.29), 1.74 (1.26, 2.40), and 1.53 (1.11, 2.11), respectively. A Fine-Gray model with death before kidney events as a competing risk showed results similar to the above. In CKD, lower and higher ferritin levels were independent risk factors for kidney disease progression.
Pottery decor as networks on the Middle Niger
Authors: Gestrich Nikolas , Schardt Juan-Marco Puerta
Published: August 2023

This paper reports on an attempt to analyse decorative techniques on archaeological pottery from the Middle Niger as knowledge exchange networks. The 12th-century CE state of this network is modelled and analysed, and then compared to its 9th-century counterpart. The analysis shows how knowledge about pottery decoration was propagated within networks of different sizes and intensities, from local, well-connected networks to more loosely tied long-distance connections. The article shows how the perspective of network analysis differs from, and can fruitfully complement, previous treatments of ceramic décor distribution in the region. It adds a novel perspective to what the distribution of archaeological ceramics in this region reflects, and contributes to the generation of hypotheses that can be further tested by fieldwork.
Evaluation of the functional state and mobility of patients after stroke depending on their cognitive state
Authors: Guzek Zbigniew , Dziubek Wioletta , Stefańska Małgorzata , Kowalska Joanna
Published: August 2023

The study aimed to analyze the effectiveness of rehabilitation in stroke patients depending on their cognitive state.
Methods: 180 patients were divided into four groups: 48 patients without symptoms of cognitive impairment (G1); 38 with mild cognitive impairment without dementia (G2); 47 with mild dementia (G3); 47 with moderate dementia (G4). The Mini Mental State Examination (MMSE), Barthel Index (BI), Sitting Assessment Scale (SAS), Berg Balance Scale (BBS), Trunk Control Test (TCT) and Test Up & Go (TUG) were used. The tests were carried out at the time of admission to the ward (T1) and at the time of discharge (T2).
Results: A statistically significant improvement was demonstrated in all parameters in the G1 group as well as in the G2 group. In the G3 group, a significant improvement was noted in the SAS-hand function, BI and BBS. In the G4 group, a significant improvement concerned only SAS - hand function. Regression analysis showed that MMSE and BI at T1 and MMSE score at T2 explained the functional status at T2.
Conclusions: Cognitive dysfunction at the time of admission to the ward and discharge may determining the patient's functional status at the time of discharge from the ward.
The minimal SUF system is not required for Fe-S cluster biogenesis in the methanogenic archaeon Methanosarcina acetivorans
Authors: Saini Jasleen , Deere Thomas , Lessner Daniel
Published: August 2023

Iron-sulfur (Fe-S) proteins are essential for the ability of methanogens to carry out methanogenesis and biological nitrogen fixation (diazotrophy). Nonetheless, the factors involved in Fe-S cluster biogenesis in methanogens remain largely unknown. The minimal SUF Fe-S cluster biogenesis system (i.e., SufBC) is postulated to serve as the primary system in methanogens. Here, the role of SufBC in Methanosarcina acetivorans, which contains two sufCB gene clusters, was investigated. The CRISPRi-dCas9 and CRISPR-Cas9 systems were utilized to repress or delete sufC1B1 and sufC2B2, respectively. Neither the dual repression of sufC1B1 and sufC2B2 nor the deletion of both sufC1B1 and sufC2B2 affected the growth of M. acetivorans under any conditions tested, including diazotrophy. Interestingly, deletion of only sufC1B1 led to a delayed-growth phenotype under all growth conditions, suggesting that the deletion of sufC2B2 acts as a suppressor mutation in the absence of sufC1B1. In addition, the deletion of sufC1B1 and/or sufC2B2 did not affect the total Fe-S cluster content in M. acetivorans cells. Overall, these results reveal that the minimal SUF system is not required for Fe-S cluster biogenesis in M. acetivorans and challenge the universal role of SufBC in Fe-S cluster biogenesis in methanogens.
Hypertension Risk Stratification and Detection of Diabetes Mellitus- II: A Machine Learning and Deep Learning Paradigm for Early Assessment using Photoplethysmography
Authors: khan Muzaffar , Singh Bikesh Kumar , Nirala Neelamshobha
Published: August 2023

Early diagnosis of prehypertensive patients is crucial in managing and preventing subsequent complications. The major challenge is that there are no alarming symptoms for the prehypertensive patients resulting in delayed diagnosis. Further, patients with hypertension have an increased risk of being diagnosed with type-2 diabetes. The existing systems are not suitable for large-scale screening. Additionally, they lack diagnostic accuracy, which is essential for early risk assessment of hypertension. This article aims to develop a diagnostic expert system for hypertension risk stratification and diabetes mellitus type 2 (DM-II) detection using photoplethysmography (PPG) signals. A total of 156 time-domain features are extracted from the PPG signal and its derivative in terms of time-span, amplitude, area, power and their ratios. ReliefF and minimum redundancy maximum relevance (mRMR) feature selection algorithms are employed to select 20 top optimal features with a correlation to systolic blood pressure (SBP) and Diastolic blood pressure (DBP). Several classification models optimized using Bayesian optimization with 10-fold cross-validation are adopted for comparison. The highest F1 scores for the Normal (NT) versus prehypertension (PHT), NT versus hypertension type 1 (HT-I) and NT versus hypertension type 2 (HT-II) are found to be 100%, 73.9%, 80.7% for SBP and 100%, 72.8%, 81.8% respectively for DBP. The F1 scores achieved by Bi-directional long short-term memory for NT vs. PHT, NT vs. HT-I, and NT vs. HT-II are 95.1%, 97.2% and 100%, respectively. Furthermore, the classification accuracy for NT vs. DM-II achieved an F1 score of 96.0%. Our results indicate that PPG can be successfully used for risk stratification of hypertension and detection of DM-II. Future work is required to prove the efficacy of the proposed technique on a larger dataset. Multi-modal or combination of clinical data with PPG for classification is also considered in future scope.
An experimental study on the failure behaviors of hybrid supercapacitors under overdischarge conditions
Authors: Wu Mingxia , Xie Shengnan , Yang Chongyang , Xue Xin , Li Heshun , Zhang Can , Xu Jiaqiang
Published: August 2023

Hybrid supercapacitors (HSCs) have higher energy density which can meet more working conditions. However, the improved energy density also brings safety hazards. Thereinto, overdischarge is a common abuse situation that can lead to performance degradation and safety issues. Herein, we fabricated a large-format pouch cell HSC with a composite cathode including activated carbon (AC) and lithium nickel cobalt manganate oxide (NCM), hard carbon (HC) anode, and ceramic polyethylene terephthalate (PET) nonwoven separator. The failure behaviors of cyclic overdischarge and external short circuit were compared, and it is found that the performance failure of HSCs caused by external short circuit is more serious than cyclic overdischarge. After 250 cycles of discharge at 0 V and 0.5 V, copper (Cu) was found on both the anode and separator, but not found at the voltage of 1.0V, 1.5V and 2.0V after 500 cycles. After external short circuit for 24 h, the electrochemical performance decreased significantly, and the energy decayed to less than 80%. 5.62 wt% Cu was found on the anode after charge and discharge once. The gas composition after external short circuit is mainly methane (CH4) and ethylene (C2H4).
Yoke Stress Analysis of New Engines by Using Finite Element Analysis
Authors: Jadhav Swapnil , Patil Lalit , Patil Atul , Bhosale Digvijay , Patil Yashraj
Published: August 2023

In this study, an assembly fixture called a "Yoke" that is used to assemble different engine types is analyzed. The new engine has some unique parts which cannot be accommodated on the yoke during the assembly. The fouling part is the outlet water pipe which fouls one of the supporting blocks during the assembly. Therefore, the aim of the present work is to effectively accommodate the fouling parts without much modifying the components by using ANSYS. In order to adapt the changing design of new engines inexpensively, this fixture has to be analyzed to identify regions where stress is concentrated. With the aid of the simulation programme ANSYS, this study successfully illustrates the integration of the finite element methods to solve complicated issues quickly. These calculations are exceedingly time-consuming to complete manually, thus simulation software like ANSYS is utilized to complete them more quickly and correctly. The results have been validated by using its mathematical model. The most secure and cost-effective modification for the yoke would be found after thorough investigation in order to successfully accommodate the fouling or clashing elements during installation.
ATP2C1 knockdown induces abnormal expressions of cytoskeletal and tight junction proteins mimicking Hailey–Hailey disease
Authors: Zhou Mingzhu , Kang Shiran , Xia Yumin , Zhang Dingwei , Chen Wenwen
Published: August 2023

Hailey–Hailey disease (HHD) is a rare, autosomal, dominant, and hereditary skin disorder characterized by epidermal acantholysis. The HHD-associated gene ATPase calcium-transporting type 2C member 1 (ATP2C1) encodes the protein secretory pathway Ca2 + ATPase1 (SPCA1), playing a critical role in HHD pathogenesis. Therefore, we aimed to investigate the effect of ATP2C1 knockdown on keratinocyte cultures that mimicked HHD. The levels of cytoskeletal and tight junction proteins such as SPCA1, P-cofilin, F-actin, claudins, occludin, and zonula occludens 1 were analyzed in skin biopsies and cultured ATP2C1 knockdown keratinocytes. The results showed decreased levels of these proteins in HHD skin lesions. Moreover, their levels decreased in human keratinocytes transfected with ATP2C1 short hairpin RNA, accompanied by morphological acantholysis. Furthermore, the proliferation and apoptosis of the keratinocytes as well as intracellular calcium concentrations in these cells were not affected. The present findings indicated that SPCA1 inhibition led to abnormal levels of the cytoskeletal and tight junction proteins in the keratinocyte cultures. Therefore, keratinocyte cultures can mimic HHD and can serve as an in vitro model, thereby helping develop treatment strategies against HHD.
High-resolution prediction models for Rhipicephalus microplus and Amblyomma cajennense s.l. ticks affecting cattle and their spatial distribution in continental Ecuador using bioclimatic factors
Authors: Pérez-Otáñez Ximena , Rodríguez-Hidalgo Richar , Enríquez Sandra , Celi-Erazo Maritza , Benítez Washington , Saegerman Claude , Vaca-Moyano Franklin , Ron-Garrido Lenin , Vanwambeke Sophie O.
Published: August 2023

In Ecuador, the main tick species affecting cattle are Rhipicephalus microplus and Amblyomma cajennense sensu lato. Understanding their spatial distribution is crucial. To assess their distribution, data from 2895 farms visited between 2012 and 2017 were utilized. Ticks were collected during animal inspections, with each farm's location georeferenced. Bioclimatic variables and vapor pressure deficit data from CHELSA were overlaid to develop predictive maps for each species using Random Forest (RF) models. The cross-validation results for RF prediction models showed high accuracy for both R. microplus and A. cajennense s.l. presence with values of Accuracy = 0.97 and 0.98, Sensitivity = 0.96 and 0.99, and Specificity = 0.96 and 0.93, respectively. A carefully selected subset of bioclimatic variables was used to describe the presence of each tick species. Higher levels of precipitation had positive effect on the presence of R. microplus but a negative effect on A. cajennense s.l. In contrast, isothermality (BIO3) resulted as more important for the presence of A. cajennense s.l. compared to R. microplus. As a result, R. microplus had a broader distribution across the country, while A. cajennense s.l. was mainly found in coastal areas with evident seasonality. The coexistence of both species in certain regions could be attributed to transitional zones, whereas high altitudes limited tick presence. This information can aid in developing appropriate tick management plans, particularly considering A. cajennense s.l.'s broad host range species and R. microplus's specificity for cattle. Moreover, the predictive models can identify areas at risk of associated challenging hemoparasite, requiring special attention and mitigation measures.
Prevalence of onychomycosis among diabetic population of District Doda (UT of J&K, India) - a five year survey
Authors: Kotwal Sandeep , Sumbali Geeta
Published: August 2023

Onychomycosis, which is the chronic fungal infection of finger and toe nails, is too prevalent in persons suffering with diabetes mellitus. Diabetes generally make a person more prone to a number of diseases due to their weakened immune system. Diabetics are almost three times more likely to develop onychomycosis than non-diabetics. In our present study, out of the 370 detected diabetic patients (190 males and 180 females), a total of 45 cases were found to be positive for onychomycosis, which showed a prevalence percentage of 12.16%. 35 onychomycotic male patients with a prevalence percentage of 9.46% and 10 onychomycotic female patients with a prevalence percentage of 2.70% with different clinical symptoms viz., Distal lateral subungual onychomycosis (DLSO), Proximal subungual onychomycosis (PSO), White superficial onychomycosis (WSO) and Total dystrophic onychomycosis (TDO) were reported. A total of 5 dermatophytes, 12 non-dermatophytes (yeast-like fungi) and 28 non-dermatophytes (filamentous fungi) were isolated from the nails of detected diabetic patients. The study also indicates that diabetic males are 3.5 times more prone to onychomycosis than diabetic females. This high prevalence of onychomycosis in diabetics is attributed to a combination of host factors including impaired glycaemic index, ischaemia, neuropathy and local immune-suppression. Onychomycosis can be especially important for some specific occupational groups because of their regular contact with soil, dirt and dust. Such people of the society, which depend upon physical labour for earning, such as, the farmers, gardeners, sweepers, maidservants, labourers, miners, etc., may be more prone to dermatophytic and non-dermatophytic onychomycosis and if they are diabetic then situation will become more complicated for them. This study also found that among detected diabetic patients highest prevalence rate of onychomycosis was found in employees (35.6%), farmers (24.4%), house-wives (17.8%), business-men (11.1%) and labourers (11.1%). Onychomycosis is a significant predictor for the development of secondary infections and foot ulcers in diabetes. Since, diabetics have vascular and nerve impairment, any minor injury to feet including a nail fungal infection can lead to more serious complications. Diabetics may have increased difficulty in doing regular foot check-ups due to obesity or retinopathy or cataracts, which may contribute to higher risk of developing complications from onychomycosis. In addition, symptoms go away very slowly and may take a year or more for the entire replacement of the old and infected nail. The study also found a correlation between the increasing age, diabetes and onychomycosis.
RETRACTED: Machine Learning Classifiers for Bot Detection using Account Level Data
Authors: Sharma Jwala , Borah Samarjeet
Published: August 2023

The authors have requested that this preprint be removed from Research Square.
Soil Erosion in Al-Adhaim River Basin, Central Part of Iraq
Authors: Sissakian Varoujan K. , Elias Ziyad , Al-Ansari Nadhir
Published: August 2023

Al-Adhaim River is a tributary of the Tigris River, it has three main tributaries: Khassa Soo, Aq Soo, and Tuz Chia, all of which are seasonal streams. The course of Al-Adhaim River and its three tributaries flow in a very rugged topography, especially in the upper courses with high gradients. The main present rocks in the catchment area are soft claystone with coarse conglomerate and sandstone, which are very easily eroded by running water, especially during floods. We have used SRTM images of ground resolution of 3-arc-second (90 m) and a vertical resolution of approximately 10 m to divide the catchment area into 14 sub-basins using ArcGIS (Arc map). Moreover, to calculate many factors concerning soil erosion, such as drainage density, erosion intensity, erosion rates, and soil erodibility. We have found that the drainage density ranges between (0.26–0.39) km/ km2 with class Poor, the Erosion Intensity ranges between (264–387) m/km2 with Very poor Zone, the Erosion rates (Kk) ranges from (0.01–0.325), and the Erosion Coefficient ranges from (0.7 − 1.0).
MiR-383 sensitizes osteosarcoma cells to cisplatin treatment via down-regulating PSMB5
Authors: Wang Haifan , Bai Chuanyi , Dang Xiaoqian , Wang Haoyu
Published: August 2023

Background： Proteasome inhibition represents a promising strategy for cancer therapy. Bortezomib, primarily targeting the chymotrypsin-like activity of PSMB5, has been proven effective in several tumors. However, variable sensitivity exits in response to bortezomib, which may be partially due to differences in the expression of proteasome subunits.
Methods and Results: In this study, we investigated whether miR-383 affects the proteasome subunits expression in osteosarcoma (OS) cells, and if so, whether OS cells display differential sensitivity to bortezomib concerning miR-383 expression. We detected a decreased miR-383 expression in OS cells and tissues. Then we found a negative correlation between bortezomib cytotoxicity and proteasome 20S core particle subunit β5 (PSMB5) expression level. Intriguingly, we found that PSMB5 is a target of miR-383. Higher expression of miR-383 led to decreased PSMB5 expression and exhibited greater sensitivity to bortezomib in OS cells.
Conclusions: In summary, our results represent the first comprehensive analysis of the role of miR-383 in OS. The results suggest that miR-383 may enhance the anticancer effect of bortezomib through PSMB5 repression, providing a novel therapeutic strategy in OS and a new pathway for proteasome regulation.
Comprehensive Ecological Health Assessment of the Qinghe River Basin: Towards Sustainable Management and Environmental Protection
Authors: Xu Chengbin , Lei Jingcheng , Zhang Jinfeng , Li Peiying , Zhang Hongliang , Meng Xuelian
Published: August 2023

Ecosystem health assessment on a large river basin scale is a crucial area of focus in ecological health evaluation, representing a prominent research direction in environmental science and landscape ecology. The Qinghe River Basin, which faces multiple environmental challenges induced by human activities, has significant impacts on both the ecological environment and the sustainable development of society and economy. In order to fully understand the ecological health status of this basin, an ecological health assessment was conducted in there. With reference to the Guidelines for Basin Ecological Health Assessment (Trial), a systematic framework was developed to establish an assessment system that includes both aquatic and terrestrial systems within the basin to ensure a comprehensive evaluation. The WHI, which is a comprehensive assessment index, was utilized for this purpose.By adopting an integrated approach, the ecological health assessment of the Qinghe River Basin provides a comprehensive evaluation of the overall condition of the river basin. The results indicate an average evaluation grade of 58.66, reflecting the overall ecological health of the Qinghe River Basin. The assessment of the ecological system in the Qinghe River Basin is an important step in understanding the current situation and major issues faced by the basin. It also provides a theoretical foundation and practical guidance for promoting sustainable development, effective management, and comprehensive environmental protection in the area. This study not only contributes valuable insights to the scientific community but also supports policymakers and stakeholders in making informed decisions to protect ecological integrity and promote sustainable development.
Research on Low-light Image Enhancement Based on MER-Retinex Algorithm
Authors: Zhou Rongfeng , Wang Rugang , Wang Yuanyuan , Zhou Feng , Guo Naihong
Published: August 2023

To solve blurring and poor visual effects after enhancement of low-light images by conventional low-light algorithms, this paper proposes a MER-Retinex (Multiscale Expansion Reconstruction Retinex) algorithm that integrates attention mechanism and multi-scale expansion pyramid reconstruction. It includes two parts: decomposition and enhancement module. In the decomposition module, two U-shaped networks are used to decompose the image into reflectance and illumination, then, use multi-layer convolution to expand the field of perception and improve the ability to decompose the image to obtain reflectance and illumination. In the enhancement module, a U-shaped network is used to fuse multi-scale expansion pyramids with a multi-attention mechanism to enrich image information, increase image brightness, and fuse the processed global information with local information to enhance the recovered image details. In the enhanced reconstruction section super-resolution techniques are used to enhance and denoise image feature details. Experimental analysis of the MER-Retinex algorithm was carried out on the LOL dataset. The PSNR of the algorithm in this paper was 25.26 and the NIQE was 3.43. The algorithm in this paper can effectively solve the problems of blurred images and poor visual effects, and has improved in both subjective perception and objective evaluation indexes.
Production Performance and Financial Analysis of Three Segments Business to Support Availability Hybrid Grouper Seeds in Marine Culture
Authors: Astari Belinda , Effendi Irzal , Budiardi Tatag , Hadiroseyani Yani , Diatin Iis , Ismi Suko
Published: August 2023

Important factors in grouper mariculture are continuous availability of seeds. Purpose of this research was to analyse production performance and financial analysis of three segments that support production of cantang hybrid grouper (macan/tiger, Epinephelus fuscoguttatus × kertang/giant, Epinephelus lanceolatus) and cantik hybrid grouper (macan/tiger, Epinephelus fuscoguttatus × batik/camouflage, Epinephelus microdon). Research was conducted for one year in 2022 three businesses, namely egg production, small-scale hatchery and nursery businesses. Egg production in a year for cantang hybrid grouper 97,300,000 eggs and cantik hybrid gouper of 17,800,000 eggs. Small-scale hatchery were harvested with average total length of ± 3.0 cm with SR 2.1–15.7% for cantang and 4.3–18.2% for cantik. Nursery were harvested with average total length of cantang seeds was 10.9 ± 0.3 cm with SR of 60.2–84.5% and seeds was 10.1 ± 0.3 cm with SR of 74.9–91.8%. Egg production obtained profit IDR 444,144,168/year, R/C ratio 1.67, and payback period 1.16 year. Egg production business in 5 years obtained NPV IDR 834,544,410, net B/C 2.63, and IRR 78.90%. Small-scale hatchery business profit IDR 414,508,032/year, R/C ratio 1.94, and payback period 1.40 year with NPV IDR 783,041,394, net B/C 2.35, and IRR 65.10%. Nursery business profit IDR 524,700,000/year, R/C ratio 1.73, and payback period 1.17 year with NPV IDR 1,097,840,171, net B/C 2.78, and IRR 79.30%. Sensitivity analysis shows that increases and decreases that occur in amount of production and selling prices have significant effect on NPV value. In addition, increase in profitability performance is associated with decrease in broodstock, eggs, seeds, feeds, or labor costs.
Sustainable Land Use Planning in Developing Countries Using GIS and Multi-criteria Analysis: A Case Study of Lalitpur District, Nepal
Authors: Thapa Narayan , Pant Pragya , Prasai Ritika , Mahata Aayush , Dulal Sujan
Published: August 2023

Nepal is facing rapid urbanization leading to unplanned land development/use. This research paper focuses on conducting a comprehensive land use suitability analysis for urban development in Lalitpur District, Nepal. By employing Geographic Information System (GIS) and Multi-criteria Analysis (MCA) techniques, this study aims to provide valuable insights into identifying suitable area for urban development and facilitating valuable insights into identifying suitable area for urban expansion and opening doors for informed decision making by planner and policy makers. By studying factors such as existing infrastructure which include land cover, population density, flood sensitivity, slope, digital elevation model (DEM), road network, distance to brick factory and land fill site, the study identified suitable areas for urban development in Lalitpur District. We divided the study area into four suitability classes: highly suitable, moderately suitable, marginally suitable, and not suitable. From our case study we found out that the highly suitable regions are typically flat, have low population densities, areas close to infrastructure, far away from landfill site, flood region and brick factory. Moderate suitable areas are typically hilly, have higher population densities, and areas farther from infrastructure. Marginal suitable areas are in floodplains, have steep slopes, and are near to industrial areas. Not suitable areas are too steep, highly prone to flood, too close to industrial areas, and have high population density. The findings of the analysis emphasize the importance of considering environmental factors in land use planning and urban development. It highlights the need to preserve green spaces, protect water bodies, and ensure the long-term well-being of residents. The results provide valuable insights for decision-makers and urban planners, enabling them to make informed decisions and allocate resources effectively.
Exploring Adverse Events Of Remdesivir In Covid-19 Patients: A Comprehensive Global Analysis
Authors: Malvade Pratik V. , Bhagat Dhanashri B. , Palve Atish S. , Navale Abhijit S. , Musmade Prajwal S. , Muntode Prasad J. , Joshi Rohit S.
Published: August 2023

Background The emergence of COVID-19, stemming from SARS-CoV-2, has triggered a global pandemic, urging rapid therapeutic interventions. Remdesivir, a nucleotide analog prodrug, garnered attention for its potential against COVID-19 due to in vitro efficacy against coronaviruses. This study reviews Remdesivir's adverse effects in COVID-19 patients.Methodology: While Remdesivir shows promise, recent studies raise efficacy concerns. Adverse drug event (ADE) documentation is vital due to limited pre-pandemic ADE data. WHO VigiBase® analysis (2015–2020) and COVID-19 ADE studies were undertaken, focusing on age, severity, region, and organ impact. 1086 ADEs emerged from 439 case reports by July 19, 2020, in VigiBase®, reducing to 1004 after duplicates were removed. ADEs primarily related to COVID-19 patients (92.5%), notably from the Americas (67.7%). Mainly in males above 45, ADEs were serious (82.5%). Key ADEs encompassed elevated hepatic enzymes (32.1%), renal damage (14.4%), increased creatinine levels (11.2%), and respiratory failure (6.4%).Conclusion Liver and kidney function deterioration emerged as frequent ADEs, underscoring the need for vigilance during Remdesivir treatment. These findings align with regulatory documents. In sum, COVID-19 has prompted swift therapeutic responses, with Remdesivir being explored as a potential treatment. This study sheds light on associated ADEs, highlighting the importance of monitoring and informed decision-making.
Változásmenedzsment a felsőoktatásban.
Authors: Korpics Márta Katalin , Bajnok Andrea
Published: August 2023

Esettanulmányunkban a Nemzeti Közszolgálati Egyetemen 2019-ben kezdődött és jelenleg is tartó, pedagógiai célú változási folyamat első szakaszát mutatjuk be, a változásokat irányító csapat tagjainak beszámolói, megélt tapasztalatai, valamint az egyetem stratégiai dokumentumai segítségével. A pedagógiai változások elérésén munkálkodó vezetők, szakemberek és oktatók a tanulási képességek hatékony fejlesztésére, értékelésére, az egyéni tanulási utak mentorálására és a személyességen alapuló, alkotó szakmai közösségek művelésére törekednek. Tanulmányunk célja a pedagógiai célú változási folyamat eredményeinek összefoglalása és elemzése, valamint a szükséges következtetések, esetleg kritikák megfogalmazása a változási folyamat eredményes folytatása érdekében, ezzel is támogatva az egyetem intézményfejlesztési törekvéseit. A felsőoktatási szervezeti változások kontextusában Kotter nyolclépéses változásmodelljét alkalmazzuk a folyamat és az eredmények bemutatására és megvitatására. A tanulmányban leírtak hasznosak lehetnek azok számára, akik hozzánk hasonlóan minőségi felsőoktatás-pedagógia kialakítására kötelezték el magukat az oktatási gyakorlat átalakításával.
Sustainable green synthesis of ZnFe2O4@ZnO nanocomposite using Oleaster tree bark methanolic extract for photocatalytic degradation of aqueous humic acid in the presence of UVc irradiation
Authors: Asri Majid , Naghizadeh Ali , Hasani Amirhesam , Mortazavi-Derazkola Sobhan , Javid Amirhossein , Masoudi Fatemehsadat
Published: August 2023

One of the most important humic substances in water is humic acid. These substances enter water sources through soils, sediments of aquatic animals, plants and sewage. Therefore, removing them from water sources is very important. In this study, the photocatalytic removal of humic acid was investigated using zinc ferrite nanoparticles loaded with zinc oxide (ZnFe2O4@ZnO). This research was conducted in an experimental-interventional way in a batch reactor on a laboratory scale. A novel and facile method was applied for catalyst synthesis in different conditions, and it was structurally and morphologically characterized by XRD, FT-IR, SEM, DLS and EDS mapping techniques. The effects of pH (3–11), nanoparticle dose (0.005–0.1 g/L), and humic acid concentration (2–15 mg/L) were examined up to 120 min of time. The results showed that the efficiency of humic acid degradation by ZnFe2O4@ZnO reached 95% in optimal conditions. Also, it was found that this nanocomposite has an acceptable reusability and recovery after being tested in five stages.
Flood forecasting by means of dynamical downscaling of global NWPs coupling with a hydrologic model at Nong Son-Thanh My River basins
Authors: Trinh Toan , Do N. , Trinh L. , Carr K.
Published: August 2023

Almost every year, Vietnam suffers floods resulting in the loss of many lives and considerable costs for damaged and lost properties. This study proposes a forecasting system that couples the dynamical downscaling technique with hydrologic models to forecast real-time flood events with a lead time ranging from one to three days. This approach is demonstrated by applying a regional numerical weather prediction and physically based hydrologic model to the Thanh My and Nong Son watersheds. System inputs are provided by two global NWPs, the global forecasting system (GFS) and the global spectral model (GSM). A WEHY-WRF was selected as the hydrologic-atmospheric component for the proposed system. WEHY-WRF was successfully implemented and validated before testing the real-time forecasting system over the Nong Son-Thanh My watersheds. Overall, the comparison between the model simulations and corresponding observations shows the rainfall and flood forecast by WEHY-WRF-GFS match quite well with observation data and perform better than WEHY-WRF-GSM. However, all forecasting results are generally encouraging considering the correlation coefficients for most events are acceptable. The forecast methodology has demonstrated it as a comprehensive reliable technology that may be universally applied for flood prediction through the coupling of dynamical downscaling technique and hydrologic models.
Experimental and statistical modeling of the effect of process modification and wastewater characterization on greenhouse gas emissions for a dairy industry wastewater treatment plant: A minimization approach
Authors: Yapıcıoğlu Pelin Soyertaş , Yalçın Hamza , Yeşilnacar Mehmet İrfan
Published: August 2023

This study aimed to determine the effect of design conditions and wastewater characterization on greenhouse gas (GHG) emissions from an industrial wastewater treatment plant. Analysis of variance, correlation analyses, heat-mapping, and principal component analyses (PCA) were performed to determine the correspondence between GHG emissions and wastewater characterization. Then, a new empirical model based on the correlation of wastewater characterization has been developed. This study has concentrated on using process modification to mitigate GHG emissions. If an aeration tank is operated at 36 h of hydraulic retention time and 20 days of solid retention time at design conditions, an average reduction of 45.4, 45.3, and 45.2% in carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) emissions, respectively, have been ensured. According to correlation analysis, a moderately significant positive correlation was found between effluent chemical oxygen demand values and CO2 and CH4 values (r = 0.909, r = 0.937). N2O emissions were closely related to Total Kjeldahl Nitrogen input values (r = 0.876). GHG emissions have been calculated using this correlation, and the results overlapped with the monitoring values. The estimated results of GHG emissions based on wastewater characterization have converged to in situ monitoring results, by an average of 82%.
WITHDRAWN: Triptolide Nanoemulsion Gel as a Transdermal Drug Delivery System: Preparation, Pharmacokinetics, and Rheumatoid Arthritis Evaluation
Authors: Yang Meng , Yang Dishun , Han Lu , Fan Zhimin , Liu Jiyong , Yuan Yongfang
Published: August 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
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must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Novel Approaches to Control Diabetes
Authors: Dmello Malissa Mathew , Bhagwat Geeta
Published: August 2023

Diabetes is a chronic, long-term, incurable, but controllable condition. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia that results from defects in insulin secretion, insulin action, or both. People who have diabetes often experience a variety of symptoms, including blurry vision, excessive thirst, fatigue, frequent urination, hunger, and weight loss. This review article includes a discussion on diabetes types, symptoms, diagnostic tests, and various therapies for treating, controlling, and managing blood glucose levels, with a focus on its most recent innovation of therapies and medications. Diabetes management will also be reviewed, along with clinical pharmacodynamics, bioavailability, advantages, and complications of combined drugs/medications.
WITHDRAWN: The Medicinal Perspective of Rasam: A Traditional Functional Food in Southern India
Authors: Eswar Sai , Arivuselvam Rajaguru , Azeeze Mohamed Sheik Tharik Abdul
Published: August 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.