bluuebunny/crossref_metadata_2025 huggingface dataset:
Floating–Harbor Syndrome: A Systematic Literature Review and Case Report
Authors: Dobrzynski Wojciech , Stawinska-Dudek Julia , Moryto Natalia , Lipka Dominika , Mikulewicz Marcin
Published: June 2024

Floating–Harbor syndrome (FHS) is an extremely rare genetic disorder connected with a distinctive facial appearance, various skeletal malformations, delayed bone age, and expressive language delays. It is caused by heterozygous mutations in the Snf2-related CREBBP activator protein (SRCAP) gene. The aim of this paper is to describe the case of a 14-year-old male with FHS, referring to a review of the literature, and to collect all reported symptoms. In addition, the orthodontic treatment of the patient is described. For this, the electronic databases PubMed and Scopus were searched using the keyword “Floating–Harbor syndrome”. Similar to previous cases in the literature, the patient presented with short stature; a triangular face with a large bulbous nose; deep-set eyes and narrow eyelid gaps; a wide mouth with a thin vermilion border of the upper lip; and dorsally rotated, small ears. They also presented some less-described symptoms, such as macrodontia and micrognathia. Moreover, mild mental retardation, microcephaly, and delayed psychomotor development were found. On the basis of an extraoral, intraoral examination, X-rays, and CBCT, he was diagnosed with overbite, canine class I and angle class III, on both sides. To the best of our knowledge, orthodontic treatment of this disease has not been assessed in detail so far, so this is the first case.
Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer
Authors: Jackson Jamaal C. , Sanchez Darren , Johns Andrew C. , Campbell Matthew T. , Aydin Ahmet M. , Gokden Neriman , Maraboyina Sanjay , Muesse Jason L. , Ward John F. , Pisters Louis L. , Zacharias Niki M. , Guo Charles C. , Tu Shi-Ming
Published: June 2024

Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate.
Risk Factors and Interventions for Suicide in Huntington’s Disease—A Systematic Review
Authors: Grimaldi Alessandro , Veneziani Isabella , Culicetto Laura , Quartarone Angelo , Lo Buono Viviana
Published: June 2024

Background/Objectives: Huntington’s disease (HD) is an autosomal dominant genetic disorder causing progressive neurodegeneration which, aside from symptomatic therapies for controlling psychological and motor problems, currently has no effective treatment. People who receive this diagnosis often feel disoriented and lost without guidance. Furthermore, HD patients are estimated to have a two to seven times greater risk of suicide death compared to the general population. The current review investigates the complex relationship between HD and suicide, seeking to identify key risk factors influencing suicidal ideation and behaviour in affected individuals. Methods: We conducted a systematic review following the PRISMA guidelines. Studies were searched for on the PubMed, Cochrane, and Web of Science databases, and 17 articles met the inclusion criteria. Results: The findings reveal that emotional strain, neuropsychiatric symptoms, and the absence of a cure contribute to heightened suicidal tendencies in HD patients. Critical periods for suicide risk coincide with early symptomatic stages of disease or the successive phase, with the loss of independence impacting on daily functioning. Risk factors associated with HD include a depressive mood, cognitive impairments, and a history of suicide attempts. Conclusions: From a prevention perspective, a comprehensive multidisciplinary and multidimensional approach could enhance the overall well-being of people with HD. In particular, screening for suicidal thoughts in people with HD could mitigate suicide risk.
Setting Sail into a New Era of Medical Research in Oman
Authors: Al Abri Rashid
Published: June 2024

It is with both great pleasure and a considerable sense of excitement that we present this inaugural issue of the Journal of the Oman Medical Association (ISSN: 2813-8759) [...]
Ultrasound Examination of Common Carotid Adventitial Thickness Can Differentiate Takayasu Arteritis and Large Vessel Giant Cell Arteritis
Authors: Macchioni Pierluigi , Germanò Giuseppe , Girolimetto Nicolò , Klinowski Giulia , Gavioli Letizia , Muratore Francesco , Laneri Alessia , Ricordi Caterina , Marvisi Chiara , Magnani Luca , Salvarani Carlo
Published: June 2024

Pathological studies have demonstrated that the adventitial layer is markedly thickened in Takayasu (TAK) as compared to large vessel giant cell arteritis (LV-GCA). An ultrasound (US) examination of the arterial vessels allows the determination of intima media thickness (IMT) and of adventitial layer thickness (extra media thickness (EMT)). No previous study has evaluated if there are differences in EMT thickness between TAK and LV-GCA. In this cross-sectional retrospective study of stored ultrasound (US) imaging, we have compared common carotid artery (CCA) EMT and IMT in a series of consecutive TAK and LV-GCA patients. US examination CCA IMT and EMT were significantly higher in TAK as compared to LV-GCA. With ROC curve analysis, we have found that an EMT > 0.76 mm has high sensitivity and specificity for TAK CCA examination. The percentage of CCA at EMT > 0.76 mm and the total arterial wall thickening were significantly higher in TAK group examinations. EMT thickness correlated with disease duration and IMT in the TAK group, as well as with the IMT and ESR values in the LV-GCA group. Upon multivariate logistic regression analysis, factors independently associated with TAK CCA were EMT > 0.76 mm and age. No significant variation in IMT and EMT could be demonstrated in subsequent US CCA examinations.
Drag Reduction by Dried Malted Rice Solutions in Pipe Flow
Authors: Watanabe Keizo , Ogata Satoshi
Published: June 2024

In this study, the friction factor of a turbulent pipe flow for dried rice malt extract solutions was experimentally reduced to that of a Newtonian fluid. The friction factor was measured for four types of solutions at different culture times and concentrations. The results indicate that the experimental data points of the test solutions diverged from the maximum drag reduction asymptote at and above Re√f ≅ 200~250 and aligned parallel to those of Newtonian fluids. This drag reduction phenomenon differed from that observed in artificial high-molecular-weight polymer solutions, called Type A drag reduction, in which the drag reduction level is dependent on the Reynolds number in the intermediate region. This is classified as a Type B drag reduction phenomenon in biopolymer solutions and fine solid particle suspensions. The order of drag reduction corresponded to approximately 5–50 ppm xanthan gum solutions, as reported previously. Furthermore, the velocity profile in a turbulent pipe flow was predicted using a semi-theoretical equation in which the friction factors were determined using the difference between the experimental results of the tested solutions and Newtonian fluids. The results indicate considerable thickening of the viscous sublayer in the turbulent pipe flow of the test solutions compared with that of Newtonian fluids.
Compression Wraps—Providing Solutions for Complex Lymphatic Presentations
Authors: Witt Susan , González-Rubino Jesús-Baltasar , Martín-Valero Rocío , Vinolo-Gil María Jesús , Dieterle Thomas
Published: June 2024

Compression is the cornerstone of treatment for lymphoedema; however, in patients with Stage III lymphoedema that causes a significant alteration of limb shape and size, additional creative problem solving is required in order to find a solution that fits the person, their limb and their personal circumstances. Medical adaptive compression (MAC) systems provide solutions to complex situations. We present two cases of individuals who completed an inpatient rehabilitation stay for intensive treatment of their lymphoedema and were fitted with MAC devices to ensure long-term success.
Synthesis of a Flaky CeO2 with Nanocrystals Used for Polishing
Authors: Zhang Yiming , Gou Li
Published: June 2024

It is important to adapt the morphology of CeO2 to different applications. A novel flaky CeO2 with nanocrystals was successfully synthesized using the ordinal precipitation method and calcination. The size of the flaky CeO2 was about 10 μm, and the nanocrystals were about 100 nm. Under the action of the precipitant NH4HCO3, Ce3+ nucleated in large quantities. The nanosized crystals gathered into flakes driven by the surface energy. As the calcination temperature increased, the grains grew slowly by mass transfer due to the slow diffusion of reactants. By adding AlOOH to the starting material, the Al3+ doped into the CeO2 increased the content of Ce3+ in the CeO2, which improved the chemical activity of the CeO2. When the starting material’s Al:Ce ratio was 5:1, the Ce3+ increased to 31.11% in the CeO2, which provided good application potential in the polishing field. After polishing by the slurry of flaky CeO2 for 1 h, the SiC surface roughness reduced from 464 nm to 11 nm.
Feasible Influence of G-CSF on Clinical Pregnancy Outcome in Oocyte Donation Cycles for Patients with Recurrent Implantation Failure
Authors: Kushniruk Nataliya , Stastna Anna , Fait Tomas , Lenertova Tereza
Published: June 2024

Background and Objectives: The aim of our single-center cohort study was the determination of the influence of the intrauterine lavage of granulocyte colony-stimulating growth factor (G-CSF) on clinical pregnancy rate in patients with a history of implantation failure older than 40 years. Materials and Methods: The study was conducted in Ferticare Prague SE between May 2018 and June 2020. Overall, 115 patients were distributed into two arms, with 48 subjects in the experimental and 67 in the control arm. All women have had a previous history of unsuccessful history of infertility treatment with their own genetic material and at least one ineffective cycle with the donated oocytes. The experimental arm underwent the intrauterine lavage of 0.5 mL of pure G-CSF from 120 to 48 h prior to embryo transfer. Results: The clinical pregnancy rate was 63.3% in the experimental arm and 47.8% in the control arm (p = 0.097 for Pearsonߣs χ2, and p = 0.133 for Fisher’s exact test). However, the mean endometrial thickness on the day of embryo transfer did not appear to be statistically different (p = 0.139). Only the difference in endometrium thickness growth was statistically significant (p = 0.023). The increase in pregnancy rate is still encouraging for the future, even if it is not significant. Conclusion: Our study suggests the trend of increased pregnancy rate after the intrauterine G-CSF lavage in the interval of 120–48 h prior to embryo transfer.
Linguistic Validation and Reliability of the Croatian Version of the TOPICOP Questionnaire
Authors: Markota Čagalj Adela , Markic Josko , Vuković Dubravka , Šitum Čeprnja Zdenka , Gogić Salapić Tina , Buljan Ivan , Pranić Shelly Melissa
Published: June 2024

Background and Objectives: This study demonstrates the factor structure and reliability of the Croatian version of the TOPICOP (Topical Corticosteroid Phobia) questionnaire, thereby contributing to further validation and standardization of the measurement of topical corticophobia with dermatological patients or their parents, which directly affects patient or parent compliance, as well as the final therapeutic effect. Materials and Methods: The cross-sectional, observational study was conducted at the University Hospital Centre Split, Department of Dermatovenerology. The research involved inviting 120 participants (age 12–68) who attended the University Hospital Centre Split’s Atopy School, patients examined in the Dermatology Outpatient Clinic of the University Hospital Centre Split and diagnosed with atopic dermatitis (AD) or allergic contact dermatitis (ACD), and parents or legal representatives of patients younger than 12 years old. The TOPICOP questionnaire consists of 12 items assessing the three different components of topical corticophobia (worries, beliefs, and behaviour). Respondents evaluated their perception of the correctness of each statement within 10 min of filling out the questionnaire on a four-point Likert scale. Results: The response rate was 94%, resulting in a sample of 113 respondents (109 adults and 4 children). Factor analysis yielded one common factor of relatively high reliability (Cronbach α = 0.85, 95% CI 0.81 to 0.89). No differences were found in questionnaire scores between male and female participants, nor between the parents/legal representatives of dermatological patients and other patients. Conclusions: This research contributes to further development of the appropriate measuring instrument, its practical application, and thus, the better recognition, resolution, and prevention of topical corticophobia as part of the better overall healthcare and treatment of chronic dermatological patients.
Dehydration of Organic Solvents from Ternary Mixtures Containing Toluene/Methanol/Water by Pervaporation
Authors: Qiao Ying , Xu Shichang , Wu Yixuan , Zhang Long , Xie Lixin
Published: June 2024

The separation of a toluene/methanol/water ternary mixture is a difficult task due to the toluene/water and toluene/methanol azeotropes. In this article, low-energy pervaporation is proposed for the separation of the ternary azeotrope toluene–methanol–water. This work investigates the effects of feed temperature, feed flow rate, and vacuum on pervaporation and compares the energy consumption of pervaporation with that of distillation. The results showed that at the optimized flow rate of 50 L/h and a permeate side vacuum of 60 kPa at 50 °C, the water and methanol content in the permeate was about 63.2 wt.% and 36.8 wt.%, respectively, the water/ methanol separation factor was 24.04, the permeate flux was 510.7 g/m2·h, the water content in the feed out was reduced from 2.5 wt.% to less than 0.66 wt.%, and the dehydration of toluene methanol could be realized. Without taking into account the energy consumption of pumps and other power equipment, pervaporation requires an energy consumption of 43.53 kW·h to treat 1 ton of raw material, while the energy consumption of distillation to treat 1 ton of raw material is about 261.5 kW·h. Compared to the existing distillation process, the pervaporation process consumes much less energy (about one-sixth of the energy consumption of distillation). There is almost no effect on the surface morphology and chemical composition of the membrane before and after use. The method provides an effective reference for the dehydration of organic solvents from ternary mixtures containing toluene/methanol/water.
On Least Squares Support Vector Regression for Predicting Mechanical Properties of Steel Rebars
Authors: Bessa Renan , Barreto Guilherme Alencar , Coelho David Nascimento , de Moura Elineudo Pinho , Murta Raphaella Hermont Fonseca
Published: June 2024

Aiming at ensuring the quality of the product and reducing the cost of steel manufacturing, an increasing number of studies have been developing nonlinear regression models for the prediction of the mechanical properties of steel rebars using machine learning techniques. Bearing this in mind, we revisit this problem by developing a design methodology that amalgamates two powerful concepts in parsimonious model building: (i) sparsity, in the sense that few support vectors are required for building the predictive model, and (ii) locality, in the sense that simpler models can be fitted to smaller data partitions. In this regard, two regression models based on the Least Squares Support Vector Regression (LSSVR) model are developed. The first one is an improved sparse version of the one introduced in a previous work. The second one is a novel local LSSVR-based regression model. The task of interest is the prediction of four output variables (the mechanical properties YS, UTS, UTS/YS, and PE) based on information about its chemical composition (12 variables) and the parameters of the heat treatment rolling (6 variables). The proposed LSSVR-based regression models are evaluated using real-world data collected from steel rebar manufacturing and compared with the global LSSVR model. The local sparse LSSVR approach was able to consistently outperform the standard single regression model approach in the task of interest, achieving improvements in the average R2 from previous studies: 5.04% for UTS, 5.19% for YS, 1.96% for UTS/YS, and 3.41% for PE. Furthermore, the sparsification of the dataset and the local modeling approach significantly reduce the number of SV operations on average, utilizing 34.0% of the total SVs available for UTS estimation, 44.0% for YS, 31.3% for UTS/YS, and 32.8% for PE.
A New Lead-Free Copper Alloy CuAl8Fe5Ni4Zn4Sn1 for Plain Bearings and Its Strengthening Mechanisms
Authors: Reetz Björn , Münch Tileman
Published: June 2024

CuAl8Fe5Ni4Zn4Sn1 (OF 2238) is a new lead-free copper alloy for plain-bearing applications that was first officially presented in a scientific journal in 2020. Soon after its invention, the use of the alloy for connecting rod bushings in heavy-duty internal combustion engines was promoted and validated with customers. The aim of this article is to describe the material properties of the new alloy in more detail than previously and explain how the advantageous properties of CuAl8Fe5Ni4Zn4Sn1 are generated. At the beginning of this article, the general development trends in the field of copper alloys for sliding applications are presented, into which the new alloy from this publication can be classified. In the main part of this publication, the authors go through the production chain of CuAl8Fe5Ni4Zn4Sn and show how the entire manufacturing process contributes to obtaining a material with a combination of high strength, ductility and sufficient toughness. This starts with fine microstructures after casting, followed by homogenisation and refinement during hot extrusion and work hardening chiefly during cold drawing. What is most surprising, however, is the finding that a strong hardening effect can be achieved in the new alloy by precipitation of fine κ-phase at temperatures of about 400 °C and air cooling without prior solution treatment. These results make it clear that there is great potential for further material developments to support material efficiency and even to expand the application limits.
Chromogenic Approach for Oxygen Sensing Using Tapered Coreless Optical Fibre Coated with Methylene Blue
Authors: Kumar Rahul , Wight Neil
Published: June 2024

In this paper, a Methylene Blue (MB)-coated tapered coreless (TCL) optical fibre sensor is proposed and experimentally investigated for oxygen sensing in the near-infrared (NIR) wavelength range of 993.5 nm. The effect of TCL diameter and MB sol–gel coating thickness on the sensitivity of the sensor was also investigated. A maximum sensitivity of 0.19 dB/O2% in the oxygen concentration range of 0–37.5% was achieved for a TCL fibre sensor with a 2 µm taper waist diameter and a 0.86 µm MB sol–gel coating thickness, with a response time of 4 min. The sensor provides reproducible results even after 7 days and is shown to be highly selective to oxygen compared to argon and ethanol at the same concentration.
Digital Eddy Current Detection Method Based on High-Speed Sampling with STM32
Authors: Cao Xiong , Li Erlong , Yuan Zilan , Zheng Kaituo
Published: June 2024

The electromagnetic eddy current non-destructive testing system enables the non-destructive analysis of surface defect information on tested materials. Based on the principles of eddy current detection, this paper presents a digital eddy current detection method using high-speed sampling based on STM32. A differential eddy current coil is used as the detection probe, and the combination of a differential bridge and a differential amplifier circuit helps to reduce common-mode noise interference. The detection signal is collected via an STM32-based acquisition circuit and transmitted to the host computer through Ethernet for digital demodulation processing. The host computer performs operations such as smoothing averaging, sinusoidal fitting, and outlier removal to extract the amplitude and phase of the detection signal. The system also visually displays the condition of the tested object’s surface in real time through graphical visualization. Testing showed that this system can operate at frequencies up to 8.84 MHz and clearly identify defects as narrow as 1 mm on the surface of the tested steel plate.
Theoretical Study of the Thermal Rate Coefficients of the H3+ + C2H4 Reaction: Dynamics Study on a Full-Dimensional Potential Energy Surface
Authors: Murakami Tatsuhiro , Takahashi Soma , Kikuma Yuya , Takayanagi Toshiyuki
Published: June 2024

Ion–molecular reactions play a significant role in molecular evolution within the interstellar medium. In this study, the entrance channel reaction, H3+ + C2H4 → H2 + C2H5+, was investigated using classical molecular dynamic (classical MD) and ring polymer molecular dynamic (RPMD) simulation techniques. We developed an analytical potential energy surface function with a permutationally invariant polynomial basis, specifically employing the monomial symmetrized approach. Our dynamic simulations reproduced the rate coefficient of 300 K for H3+ + C2H4 → H2 + C2H5+, aligning reasonably well with the values in the kinetic database commonly utilized in astrochemistry. The thermal rate coefficients obtained using both the classical MD and RPMD techniques exhibited an increase from 100 K to 300 K as the temperature rose. Additionally, we analyzed the excess energy distribution of the C2H5+ fragment with respect to temperature to investigate the indirect reaction pathway of C2H5+ → H2 + C2H3+. This result suggests that the indirect reaction pathway of C2H5+ → H2 + C2H3+ holds minor significance, although the distribution highly depends on the collisional temperature.
Metal-Free Cascade Formation of C–C and C–N Bond for the Construction of 3-Cyano-2-Pyridones with Insecticidal Properties
Authors: Tang Yao , Wu Nvjiang , Xu Junyu , Zhang Xiaopo , Li Youbin , Wang Xuesong
Published: June 2024

A straightforward and efficient methodology has been developed for the synthesis of 3-cyano-2-pyridones via the C–C and C–N bond formation processes. A total of 51 diverse 3-cyano-2-pyridone derivatives were obtained in moderate to excellent yields. This reaction featured advantages such as a metal-free process, wide functional group tolerance, simple operation, and mild conditions. A plausible mechanism for the reaction was proposed. 3-cyano-2-pyridones as ricinine analogues for insecticidal properties were evaluated, and the compound 3ci (LC50 = 2.206 mg/mL) showed the best insecticidal property.
Composite “Crosslinked Polyvinyl Alcohol-Magnetite” as a Stimuli-Responsive Matrix for Optical Methods
Authors: Shchemelev Ivan S. , Ivanov Alexander V. , Ferapontov Nikolay B.
Published: June 2024

The preparation and application of the composite material “crosslinked polyvinyl alcohol—magnetite” as a sensitive matrix for use in digital colorimetry and optical micrometry methods are discussed. The material was synthesized in the form of spherical granules (for micrometry) and thin films (for digital colorimetry). The obtained composites were characterized by the registration of magnetization curves. It was shown that the amount of grown Fe3O4 particles in the polymer gel is in linear dependence with the iron salt concentrations in the impregnating solutions. The composite granules were applied to determining monosaccharides using optical micrometry. The optimal pH value for the total amount of monosaccharides’ determination was 8.6. The study of the analytical response of composite granules and films performed with a low limit of detection (7.9 mmol/dm3) of both glucose and fructose and a possibility of the control of high alcohol contention in water media. The granules were used to determine the total carbohydrate content in samples of natural honey and syrups with high fructose contents, while the films were used to control the alcohol content in hand antiseptics. The results obtained are in good agreement with the data provided by the manufacturers.
Temporin-GHaK Exhibits Antineoplastic Activity against Human Lung Adenocarcinoma by Inhibiting the Wnt Signaling Pathway through miRNA-4516
Authors: Liu Yueli , Liu Hui , Zhang Jiaxin , Zhang Yingxia
Published: June 2024

(1) Background: GHaK is derived from the antimicrobial peptide temporin-GHa by substituting the amino acid H with K to enhance its bactericidal activity. The present research aims to broaden the pharmacological potential of GHaK by exploring its antineoplastic activity against human lung adenocarcinoma. (2) Methods: The cell viability, migration, invasion, apoptosis, and cell cycle of A549 and PC-9 cells were tested after GHaK treatment. miRNA sequencing, RT-PCR, Western blotting, and luciferase reporter gene assay were further performed to reveal the potential mechanism. (3) Results: GHaK significantly suppressed cell viability, migration, and invasion; induced apoptosis; and caused cell cycle arrest in the G2/M and S phase in PC-9 and A549 cells, respectively. The miRNA sequencing results show a total of 161 up-regulated and 115 down-regulated miRNAs. Furthermore, the study identified six up-regulated miRNAs (miR-4516, miR-4284, miR-204-5p, miR-12136, miR-4463, and miR-1296-3p) and their inhibitory effects on the expressions of target genes (Wnt 8B, FZD2, DVL3, and FOSL1) caused by miR-4516 directly interacting with Wnt 8B. Western blotting revealed the down-regulation of p-GSK-3β, along with a decreased expressions of cyclin A1 and CDK2 in A549 cells and cyclin B1 and CDK1 in PC-9 cells. (4) Conclusions: Temporin-GHaK exhibits antineoplastic activity against human lung adenocarcinoma by inhibiting the Wnt signaling pathway through miRNA-4516.
Insights into Halogen-Induced Changes in 4-Anilinoquinazoline EGFR Inhibitors: A Computational Spectroscopic Study
Authors: Alagawani Sallam , Vasilyev Vladislav , Clayton Andrew H. A. , Wang Feng
Published: June 2024

The epidermal growth factor receptor (EGFR) is a pivotal target in cancer therapy due to its significance within the tyrosine kinase family. EGFR inhibitors like AG-1478 and PD153035, featuring a 4-anilinoquinazoline moiety, have garnered global attention for their potent therapeutic activities. While pre-clinical studies have highlighted the significant impact of halogen substitution at the C3’-anilino position on drug potency, the underlying mechanism remains unclear. This study investigates the influence of halogen substitution (X = H, F, Cl, Br, I) on the structure, properties, and spectroscopy of halogen-substituted 4-anilinoquinazoline tyrosine kinase inhibitors (TKIs) using time-dependent density functional methods (TD-DFT) with the B3LYP functional. Our calculations revealed that halogen substitution did not induce significant changes in the three-dimensional conformation of the TKIs but led to noticeable alterations in electronic properties, such as dipole moment and spatial extent, impacting interactions at the EGFR binding site. The UV–visible spectra show that more potent TKI-X compounds typically have shorter wavelengths, with bromine’s peak wavelength at 326.71 nm and hydrogen, with the lowest IC50 nM, shifting its lambda max to 333.17 nm, indicating a correlation between potency and spectral characteristics. Further analysis of the four lowest-lying conformers of each TKI-X, along with their crystal structures from the EGFR database, confirms that the most potent conformer is often not the global minimum structure but one of the low-lying conformers. The more potent TKI-Cl and TKI-Br exhibit larger deviations (RMSD > 0.65 Å) from their global minimum structures compared to other TKI-X (RMSD < 0.15 Å), indicating that potency is associated with greater flexibility. Dipole moments of TKI-X correlate with drug potency (ln(IC50 nM)), with TKI-Cl and TKI-Br showing significantly higher dipole moments (>8.0 Debye) in both their global minimum and crystal structures. Additionally, optical spectral shifts correlate with potency, as TKI-Cl and TKI-Br exhibit blue shifts from their global minimum structures, in contrast to other TKI-X. This suggests that optical reporting can effectively probe drug potency and conformation changes.
Highly Conductive and Long-Term Stable Phosphorene-Based Nanocomposite for Radio-Frequency Antenna Application
Authors: Song Kibum , Ha Seungho , Shin Keun-Young
Published: June 2024

In this study, an omnidirectional and high-performance free-standing monopole patch radio-frequency antenna was fabricated using a urea-functionalized phosphorene/TiO2/polypyrrole (UTP) nanocomposite. The UTP nanocomposite antenna was fabricated via ball milling of urea-functionalized phosphorene, chemical oxidative polymerization of the UTP nanocomposite, and mechanical pelletizing of the composite. Based on experiments, the proposed UTP nanocomposite-based antenna exhibited long-term stability in terms of electrical conductivity. After 12 weeks, a slight change in surface resistance was observed. The proposed antenna exhibited high radiation efficiency (78.2%) and low return loss (−36.6 dB). The results of this study suggest the potential of UTP nanocomposite antennas for applications in 5G technology.
A Novel Summer Camp Integrating Physical, Psychological, and Educational Health in Youth: The THINK Program
Authors: Bonner Joseph , Xiong Wei , Velasquez Carolina , Nienhuis Natasha , Wallace Brady , Friedman Alexis , Lee Debbiesiu , Perry Arlette
Published: June 2024

Numerous youth summer programs focus upon physical fitness, nutritional health, psychological well-being, or education. Few, however, have integrated all of these elements into a single program. The Translational Health in Nutrition and Kinesiology (THINK) program provides an integrative nutrition and exercise science curriculum that is interfaced with social emotional learning (SEL) and STEM education to enhance healthy behaviors in youth. The purpose of this study was to determine whether the THINK program could improve physical fitness, nutrition habits, SEL, and STEM education in a 6-week summer program covering a 3-year period. Participants from South Miami were enrolled in THINK (n = 108, 58 males, 50 females, 12.03 + 0.56 years). Physical fitness assessments, the Positive Youth Development Inventory (PYDI), the Students’ Attitude Towards STEM Survey, and the Adolescent Food Habits Checklist (ADFH) were recorded at baseline and post-testing. Means and standard error values were evaluated for all dependent variables. Paired samples t-tests (SPSS version 27) were used to determine changes. Improvements in cardiorespiratory fitness (p < 0.001), power (p < 0.006), flexibility (p < 0.001), agility (p < 0.001), muscular endurance (p < 0.001), lean body mass (p < 0.001), ADFH (p < 0.001), and PYDI (p = 0.038) were found. An integrative summer fitness program can result in improvements in physical fitness, nutrition habits, and SEL in as little as six weeks.
Cytomegalovirus, Epstein-Barr Virus, Herpes Simplex Virus, and Varicella Zoster Virus Infection Dynamics in People with Multiple Sclerosis from Northern Italy
Authors: Maple Peter A. , Tanasescu Radu , Constantinescu Cris S. , Valentino Paola , Capobianco Marco , D’Orso Silvia , Borsellino Giovanna , Battistini Luca , Ristori Giovanni , Mechelli Rosella , Salvetti Marco , Gran Bruno
Published: June 2024

Previous exposure to Epstein–Barr virus (EBV) is strongly associated with the development of multiple sclerosis (MS). By contrast, past cytomegalovirus (CMV) infection may have no association, or be negatively associated with MS. This study aimed to investigate the associations of herpesvirus infections with MS in an Italian population. Serum samples (n = 200) from Italian people with multiple sclerosis (PwMS) classified as the relapsing-and-remitting clinical phenotype and (n = 137) healthy controls (HCs) were obtained from the CRESM Biobank, Orbassano, Italy. Both PwMS and HCs samples were selected according to age group (20–39 years, and 40 or more years) and sex. EBV virus capsid antigen (VCA) IgG, EBV nucleic acid-1 antigen (EBNA-1) IgG, CMV IgG, herpes simplex virus (HSV) IgG, and varicella zoster virus (VZV) IgG testing was undertaken using commercial ELISAs. EBV VCA IgG and EBNA-1 IgG seroprevalences were 100% in PwMS and 93.4% and 92.4%, respectively, in HCs. EBV VCA IgG and EBNA-1 IgG levels were higher (p < 0.001) in PwMS compared with HCs. For PwMS, the EBNA-1 IgG levels decreased with age, particularly in females. The CMV IgG seroprevalence was 58.7% in PwMS and 62.9% in HCs. CMV IgG seroprevalence increased with age. The HSV IgG seroprevalence was 71.2% in PwMS and 70.8% in HCs. HSV IgG levels were lower (p = 0.0005) in PwMS compared with HCs. VZV IgG seroprevalence was 97.5% in PwMS and 98.5% in HCs. In the population studied, several herpesvirus infections markers may have been influenced by the age and sex of the groups studied. The lack of a negative association of MS with CMV infection, and the observation of lower levels of HSV IgG in PwMS compared with HCs are findings worthy of further investigation.
The Effects of Dog Behavioural Problems on Owner Well-Being: A Review of the Literature and Future Directions
Authors: Barcelos Ana Maria , Kargas Niko , Mills Daniel
Published: June 2024

Dog behavioural problems are one of the main reasons for dog relinquishment. Studies on how dog behavioural problems affect owner well-being are limited. We review the literature concerning the link between dog behavioural problems and owner well-being. We propose practical solutions to minimize the negative impacts of behavioural problems on human well-being and dog welfare, whilst suggesting future research directions. Twenty-one studies were included in the literature review. These indicate that dog behavioural problems may particularly reduce social interactions, and increase negative emotions of high arousal, such as stress and frustration, caregiver burden and symptoms of both depression and anxiety in their owners. To improve both owner well-being and dog welfare, we suggest targeting three areas: practical behavioural support for the dog–human dyad, social support for owners and psychological support for owners. Considering the lack of research in the field, further studies are needed to better understand the relationship between dog behavioural problems and human well-being, such as how the three areas previously mentioned may affect dog relinquishment and owner well-being.
In Vitro Antibiofilm Activity of Fosfomycin Alone and in Combination with Other Antibiotics against Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa
Authors: Slade-Vitković Mia , Batarilo Ivanka , Bielen Luka , Maravić-Vlahoviček Gordana , Bedenić Branka
Published: June 2024

Background: Due to its rapid resistance development and ability to form biofilms, treatment of Pseudomonas aeruginosa infections is becoming more complicated by the day. Drug combinations may help reduce both resistance and biofilm formation. Methods: Using the microtiter plate assay, we investigated the in vitro inhibition of biofilm formation and the disruption of preformed biofilms in multidrug-resistant and extensively drug-resistant clinical isolates of P. aeruginosa in the presence of peak plasma levels of eight antipseudomonal antibiotics alone and in combination with fosfomycin: ceftazidime, piperacillin/tazobactam, cefepime, imipenem, gentamicin, amikacin, ciprofloxacin and colistin. Results: Combination therapy was significantly superior to monotherapy in its inhibition of biofilm formation. The highest inhibition rates were observed for combinations with colistin, cefepime and ceftazidime. Conclusion: Our results support fosfomycin combination therapy as an enhanced prophylactic option. Moreover, combinations with β-lactam antibiotics and colistin demonstrated a more potent inhibition effect on biofilm formation than protein synthesis inhibitors.
Kierkegaard’s Descriptive Philosophy of Religion: The Imagination Poised between Possibility and Actuality
Authors: Gouwens David J.
Published: June 2024

Rethinking the powers of the imagination, Søren Kierkegaard both anticipates and challenges contemporary approaches to a descriptive philosophy of religion. In contrast to the reigning approaches to religion in his day, Kierkegaard reconceives philosophy as, first of all, descriptive of human, including specifically ethical and religious, existence. To this end, he develops conceptual tools, including a descriptive ontology of human existence, a “pluralist epistemology” exploring both cognitive and passional dimensions of religion, and a role for the poetic in philosophy, strikingly expressed in his observer figures who “imaginatively construct” “thought projects” to explore human existence. While this new descriptive account anticipates subsequent approaches to the philosophy of religion, it could be interpreted as another “objectivist” endeavor, yet Kierkegaard attempts more in this descriptive philosophy. He imaginatively deploys conceptual and rhetorical strategies maieutically to both describe and elicit self-reflection aimed at transformation, thus expanding the imagination’s uses for his readers. Comparing Kierkegaard to Pierre Hadot’s recovery of ancient Greek philosophy as “a way of life” will show how Kierkegaard also engages the particularity of “the Christian principle”, with implications for how philosophy can both describe and elicit the pathos of other religious traditions as well.
Nanocellulose: The Ultimate Green Aqueous Dispersant for Nanomaterials
Authors: Calvo Víctor , Martínez-Barón Carlos , Fuentes Laura , Maser Wolfgang K. , Benito Ana M. , González-Domínguez José M.
Published: June 2024

Nanocellulose, a nanoscale derivative from renewable biomass sources, possesses remarkable colloidal properties in water, mechanical strength, and biocompatibility. It emerges as a promising bio-based dispersing agent for various nanomaterials in water. This mini-review explores the interaction between cellulose nanomaterials (nanocrystals or nanofibers) and water, elucidating how this may enable their potential as an eco-friendly dispersing agent. We explore the potential of nanocellulose derived from top-down processes, nanocrystals, and nanofibers for dispersing carbon nanomaterials, semiconducting oxide nanoparticles, and other nanomaterials in water. We also highlight its advantages over traditional methods by not only effectively dispersing those nanomaterials but also potentially eliminating the need for further chemical treatments or supporting stabilizers. This not only preserves the exceptional properties of nanomaterials in aqueous dispersion, but may even lead to the emergence of novel hybrid functionalities. Overall, this mini-review underscores the remarkable versatility of nanocellulose as a green dispersing agent for a variety of nanomaterials, inspiring further research to expand its potential to other nanomaterials and applications.
MES-FES Interface Enhances Quadriceps Muscle Response in Sitting Position in Incomplete Spinal Cord Injury: Pilot Study
Authors: Ribeiro Denise Bolonhezi , Sartori Larissa Gomes , Méndez María Verónica González , Souza Roger Burgo de , Campos Daniel Prado , Júnior Paulo Broniera , Junior José J. A. Mendes , Krueger Eddy
Published: June 2024

Purpose: In incomplete spinal cord injury (SCI), there is a partial decrease in motor or sensory or autonomic function. Mainly due to the motor impairment in SCI, a muscle–machine interface is a tool that can bring functional benefits to this population. Objective: To investigate the feasibility of the non-invasive myoelectric signal–functional electrical stimulation (MES-FES) interface on the response of the quadriceps muscle in an individual with incomplete SCI. Methods: This is a quasi-experimental, uncontrolled, longitudinal case report study carried out with an individual with incomplete SCI in the chronic phase. The assessments performed before (pre) and after eight (post8) interventions were neuromuscular assessment (surface electromyography (EMG) in rectus femoris (RF) and vastus lateralis (VL) muscles); muscle strength (load cell); knee extension range of motion (goniometry); spasticity (Modified Ashworth Scale); and quality of life (Spinal Cord Injury Quality-of-Life Questionnaire (SCI-QoL.Br)). The MES-FES interface was associated with physical therapy exercises on the extension knee joint muscle group. Results: Improvement in neuromuscular activation (normalized increase in EMGRMS of 2% (RF) and 3.3% (VL)) and synchronism of the motor units (normalized reduction in EMGMDF of 22.8% (RF) and 5.9% (VL)); 1.4 kgf increase in quadriceps strength; 10.6° increase in knee joint extension amplitude; 1 point spasticity reduction; improved quality of life, confirmed by a 12-point reduction in the SCI-QoL.Br score. Moreover, along with interventions, the participant increased the correct FES activation rate, indicating a user learning curve (ρ = 0.78, p-value = 0.04). Conclusions: The MES-FES interface associated with physical therapy promotes neuromuscular and quality of life improvements in the SCI participant.
Determinants of Temperature Development during Dental Implant Surgery
Authors: Sekura Kirsten , Erbel Carolin , Karl Matthias , Grobecker-Karl Tanja
Published: June 2024

Mechanical and thermal trauma during implant surgery may be reasons for initial peri-implant bone loss. Temperature development during drilling and implant insertion were quantified in this series of in vitro and animal experiments. Polyurethane foam material mimicking different classes of alveolar bone was used as a model material for simulating implant surgery. Using thermocouples, temperature development was determined in the model material at depths of 3 mm and 10 mm during site preparation and implant insertion. Additionally, an infrared camera allowed for measuring drill temperatures both in vitro and as part of an animal trial using an intraoral minipig model. Drill diameter and repeated usage of drills did not have a major effect on temperature generation. The addition of a diamond-like carbon coating, bone density, predrilling, and irrigation heavily affected intraosseous temperatures. In vivo, applying regular drill protocols, an intraosseous temperature rise of approximately 3 °K was determined. Implant geometry as well as the amount of undersizing of an osteotomy governed heat generation during implant insertion. Drill protocols and the amount of undersizing of an implant osteotomy constitute parameters by which clinicians can limit trauma during implant surgery.
The Feasibility of Using Marble Cutting Waste in a Sustainable Building Clay Industry
Authors: El-Mahllawy Medhat S. , Kandeel Ayman M. , Abdel Latif Mahmoud L. , El Nagar Abdeen M.
Published: June 2024

This study evaluates the feasibility of stabilizing clay bricks with marble cutting waste (MCW). This waste is currently discarded in huge quantities as sludge resulting from the sawing of marble blocks to slabs and the processes of disposing of grinding and polishing marble in landfills located around the marble processing factories in the Shaq El-Thoban industrial zone, Cairo governorate, Egypt, which causes negative impacts on the environment, health, and sustainable development. Experimental investigations were carried out to explore the effect of the addition of MCW in different clay–base mixes using varying percentages of up to 20% at the expense of the hydrated lime. Cement, hydrated lime, and MCW are the three types of solidification agents used, and clay and sand were also added in the formulations of the unfired clay brick specimens. Laboratory cylindrical stabilized and compressed specimens were made; then, they were cured in a humidity chamber for two weeks and four weeks. Afterwards, they were air dried, tested, and evaluated according to the Egyptian code for the building by the stabilized and compressed earth soil (ECBS, 2016). To enhance the durability of the cured specimens, transparent silicon-based paint was used. The results demonstrated that the optimum content of marble sludge waste (MCW) was 15% when used as replacement for hydrated lime in the production of stabilized clay brick. For all of the samples, the use of silicon-based paint was found to improve the strength and water resistance of the stabilized clay bricks. The use of local waste materials as a substitute for a hydrated lime binder reduces both the cost and environmental impact associated with block production.
Microphysical Characteristics of Melting Layers in North China Revealed by Aircraft and Radar
Authors: Hu Xiangfeng , Hou Shaoyu , Yang Jiefang , Zhao Shuwen , Zhang Xiaorui , Tao Yue , Li Hongyu , Zhang Xiaotuo , Huang Hao
Published: June 2024

The microphysical processes within the melting layer (ML) of stratiform clouds have been understudied, particularly regarding their intricate properties and behaviors. This study explores the ML’s microphysical characteristics in three distinct stratiform cloud occurrences over North China from 2017 to 2019. Our findings reveal that the reflectivity factor, coupled with the volume-weighted diameter (Dm), escalates within the upper and middle sections of the ML across all cases, suggesting that aggregation, primarily in the top 40% of the ML, significantly enhances the bright band phenomenon. Notably, the 2019 case (Spiral3) displayed more vigorous aggregation activities compared to the 2017 event (Spiral1), possibly due to larger initial particle sizes, leading to a swift increase in both mean and maximum particle diameters. Conversely, in the lower 60% of the ML, ongoing melting reduces mean particle diameters and potentially decreases total number concentration (Nt) due to accelerated particle descent. However, the 2018 case (Spiral2) deviated by showing a rapid Nt increase in the lowest 20% of the ML, where breakup mechanisms counteracted melting effects. The MLs in Spiral1 and Spiral3, in which aggregates were mainly formed by plate-like ice crystals, were thicker than those in Spiral2, dominated by low-density aggregates formed by the combination of needle and columnar ice crystals. This analysis underscores how variations in particle characteristics, such as habit, density, and size, along with thermodynamic conditions, dictate the onset temperature for melting, ML thickness, and dominant microphysical processes, which differ markedly among the cases.