bluuebunny/crossref_metadata_2025 huggingface dataset:
The Combination of Chrysin and Cisplatin Induces Apoptosis in HepG2 through
Down-regulation of cFLIP and Activity of Caspase
Authors: Li Xin , Wang Jian-Ning , Luo Yang-Xin , Peng Bao-Ying , Chen Zheng-Hao , Xiong Xi-Kun , Huang Jun-Ming , Chen Mei-Fen , Wang Feng-Yan
Published: June 2022

Aim:

The study aims to investigate the combined effects of chrysin and cisplatin on hepatoma(HepG2) cell
lines in vivo and in vitro.

Objective:

Studies have suggested that chrysin can enhance the sensitivity of tumor cells to apoptosis. Drug resistance
in tumor cells reduced the effectiveness of chemotherapy drugs such as cisplatin. We investigated whether the combination
of chrysin and cisplatin can induce more apoptosis than chrysin alone and cisplatin alone.

Methods:

HepG2 cells were pretreated with chrysin for 2 h, followed by the addition of cisplatin for another 24 h. The
morphologic changes were observed under inverted microscope and the cell viability was measured using the MTT
test. The protein and cleavage of caspase-3,8,9, PARP, and cFLIP were determined by Western blotting.

Results:

The cell viability of the HepG2 cell can be reduced by the combination of chrysin pretreatment for 2 h and
cisplatin addition for 24 h; Caspase-3,8,9 and PARP were cleaved after 12 h treatment with chrysin and cisplatin; Pancaspase
inhibitor, Z-VAD-fmk, could reverse the apoptosis induced by chrysin and cisplatin in HepG2 cells; cFLIP
was down-regulated by the combination of chrysin and cisplatin, and could be reversed by Z-VAD-fmk; the xenografted
HepG2 cells formed a tumor in one week; At the end of the experiment, there were significant differences in relative
tumor volume (RTV) and relative tumor proliferation rate between the combined group and the control group, the
chrysin group and the cisplatin group; Western blotting showed that the levels of PARP, cFLIP, and caspase-3 proteins
in isolated tumor tissues also decreased under the combined action of chrysin and cisplatin.

Conclusion:

The combination of chrysin and cisplatin induces apoptosis of hepatic tumor in vivo and in vitro. It downregulates
cFLIP and then activates caspase-8, which triggers caspase-mediated apoptosis of HepG2 cell.
Extensive Multifocal Emphysematous Osteomyelitis of Spine: A Rare Case and a Review of Literature
Authors: Angrup Archana , Sharma Bhawna , Lakhanpal Vikas , Goyal Abeer , Shree Ritu , Raj Shashank , Sreenivasan Priya , Biswal Manisha , Ray Pallab
Published: June 2022

Background:

Emphysematous osteomyelitis (EO) is an extremely rare form of osteomyelitis which is complicated mainly by infection with gas-forming organisms. The common causative agents of this disease are mainly members of Enterobacteriaceae family, the most common are Escherichia coli and Klebsiella pneumoniae along with anaerobes. A total of 48 cases of EO have been reported in the literature till now globally and none have documented the isolation of Corynebacterium amycolatum.

Case Presentation:

We report a rare case of emphysematous osteomyelitis of the spine and pelvis due to Escherichia coli along with the isolation of Corynebacterium amycolatum from the same pus samples on two consecutive occasions in a 50-year-old female with uncontrolled diabetes mellitus, who was successively treated with antibiotics and drainage of pus. We also did a brief review of the literature of all cases reported till now.

Conclusion:

The role of Corynebacterium amycolatum in the etiology of emphysematous osteomyelitis needs to be evaluated further in future studies as we cannot completely ignore its isolation in two consecutive samples as a mere contaminant.
Knowledge and Perceptions Regarding the use of Antibiotics and Self-diagnosis: A Comparative Study of the Urban and Suburban Communities in Karawang, Indonesia
Authors: Gatera Vesara A. , Supadmi Woro , Prastika Litha M. , Rohaida Deby T. , Barliana Melisa I. , Abdulah Rizky
Published: June 2022

Background:

To avoid antibiotic resistance, acute respiratory infections (ARIs) require the use of appropriate antibiotics. As a result, having the appropriate knowledge and perceptions is critical for achieving successful clinical outcomes.

Objective:

The purpose of this study was to determine the relationships and differences in knowledge and perceptions about antibiotics and ARI in urban and suburban communities in the Karawang Regency of West Java Province, Indonesia.

Methods:

We used a validated questionnaire approach to conduct a cross-sectional study in primary health care facilities. We surveyed 440 respondents from urban areas and 464 respondents from suburban areas.

Results:

Respondents in both urban and suburban areas agreed that self-diagnosis should not be used to prescribe antibiotics. False knowledge and perceptions about antibiotic use were more prevalent in suburban respondents than urban respondents. Additionally, a significant correlation between education levels and knowledge and perception was observed in both areas. Furthermore, significant correlations between age and occupation, as well as knowledge and perceptions, were identified in urban areas.

Conclusion:

Our study suggests that additional efforts are needed to increase awareness and ensure appropriate antibiotic use in the community.
Biomedical Applications of Agar and its Composites: A Mini-Review
Authors: Surendran Greeshma , Sherje Atul P.
Published: June 2022

Agar is a flexible biopolymer that forms jelly like consistency when mixed with water. It
is extracted from seaweeds by treatment with alkali and can also be synthesized from fructose-6-
phosphate. Agar and its composites were found to have applications in drug delivery, wound healing,
tumour therapy and hyperthermia treatment. Agar gel formulations have been used for ultrasound
imaging since it has the ability to scatter sound waves. It has been investigated that agar has
the ability to act as a matrix for the modified release of drugs. Agar/collagen composites were found
to be useful in the healing of wounds, burns, and ulcers. Agar also has the ability to act as a matrix
for carbonyl iron, which is found to have good thermal conductivity and became useful for the
treatment of hyperthermia. This review summarizes the properties, sources, biosynthesis, extraction,
and recent biomedical applications of agar and its composites.
WITHDRAWN: Preeclampsia: Long Term Prognosis in Mother and their Children
Authors: Sandhu Navjot Kaur , Ashique Sumel , Khatun Tahamina
Published: June 2022

The article has been withdrawn from the journal “Current Biotechnology” as it has already been submitted in the journal “Current Women's Health Reviews”.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
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must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
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authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
The Potential of Microbubbles as a Cancer Eradication Theranostic Agent
Authors: Chaudhary Atul , Setia Aseem , Singh Dilpreet , Bhattacharya Sankha
Published: June 2022

Microbubbles are a new kind of delivery system that may be used to treat a variety of
illnesses, including cancer. Microbubble is a non-invasive technology that uses microscopic gasfilled
colloidal particle bubbles with a size range of less than 100 micrometres. This unique carrier
has been used in a variety of applications in the last decade, ranging from basic targeting to ultrasound-
mediated drug delivery. The oxygen in the microbubble lasts longer in the water. The drug
release mechanism is highly regulated, since it releases the medication only in the appropriate
areas, increasing the local impact while reducing drug toxicity. This carrier is exceptional in cancer
medication delivery because of its sustained stability, encapsulation efficiency, and drug targeting.
In this paper, we provide a comprehensive analysis of microbubble technology, including its manufacturing
techniques and use in cancer medication delivery.
Optimization of Process for Removal of Fe-Cu from Wastewater
with Biodegradable Adsorbent
Authors: Rane Nitin M. , Shewale Sandeep P.
Published: June 2022

Background:

Optimization of a process for removing Fe-Cu from wastewater with biodegradable adsorbents.

Objective:

The objective of the study is to remove copper ions from wastewater. The use of low-cost adsorbents was investigated as a replacement to the conventional methods of removing heavy metals from an aqueous solution.

Methods:

Removal of copper (II) from an aqueous solution by the adsorbent made from the jackfruit peels was investigated and analyzed with the help of UV-spectroscopy. The conventional methods of treatment for heavy metal contamination include chemical precipitation, chemical oxidation, ion exchange, reverse osmosis, membrane separation, electrodialysis, and so on. These techniques are very costly, require energy in huge quantities, and generate toxic byproducts. On the other hand, adsorption has been investigated as a cost-effective method for the removal of heavy metals from wastewater. The equilibrium adsorption level was determined as a function of particle size, adsorbent doses, and variable concentration of metal ion solution. Adsorption isotherms of Cu (II) on adsorbents have been decided and correlated with isotherm equations that include Langmuir and Freundlich models.

Results:

From the experiment, the maximum percentage of copper removed is 84.30%, and the maximum adsorption capacity is 11.24 mg/g for particle size of 0.212 mm, 30.98 mg/g for 1 gram of adsorbent dose and 5.23 mg/g for 300 ppm of concentration of metal ion solution.

Conclusion:

The adsorbent made from the jackfruit peels is more effective for removing copper from aqueous solutions emitted from the industrial wastes and can prove to be the best alternative to the conventional method.
BURNOUT AND JOB SATISFACTION AMONG FAMILY PHYSICIANS
Authors: GOKDEMİR Ozden , AKYOL Gamze , AYGÜN Olgu , BULUT Ülkü , GÜLDAL Azize Dilek
Published: June 2022

Aim: Burnout syndrome is a major problem, especially among health care workers. The higher the sense of individual skills and achievement, the lower the likelihood of burnout syndrome. The objective of the study is to measure the level of burnout and job satisfaction of family physicians. Methods: Both data of the Family Physicians (FPs) who are working in rural and urban has been included in the study. The study is designed to measure their level of burnout and job satisfaction using the Maslach Burnout Inventory, Minnesota Work Satisfaction Questionnaire. Their relationship with the working area and other factors is also analyzed. Results: Maslach depersonalization subscale was found to be significantly higher in those who lived alone, those who defined their location as rural, and those who did not participate in continuing medical education (CME) (p=0.02, p=0.01, p=0.03). While Maslach personal achievement score was low in those who define their location as rural (p=0.01) it was found to be higher in women and those who did not participate in CME (p=0.02, p=0.03). In addition, as age increases, Maslach emotional burnout and depersonalization scores decrease and personal success scores increase (r =-0.169, -0.205, 0.163 and p=0.00, p=0.00, p=0.00). Conclusions: Emotional and total burnout scores decreased with age, and that attending CME increased personal achievement. CME could be a beneficial tool not only to support FPs but also to prevent burnout.
Hastane Okullarına Giden Süreğen Hastalığı Olan Çocukların Sağlıkla İlgili Yaşam Kalitesi Düzeyleri: Betimsel bir çalışma
Authors: YURDABAKAN İmge , YILDIZ DEMİRTAŞ Vesile
Published: June 2022

Amaç: Bu araştırmada süreğen hastalığı nedeniyle hastanede yatarak tedavi gören ve bu sırada hastane okulunda/sınıfında eğitimini sürdüren öğrencilerin yaşam kalite düzeyleri bazı değişkenlere göre karşılaştırmalı olarak incelenmiştir. Yöntem: Araştırma İzmir’de bulunan üç hastane okulunda/sınıfında gerçekleştirilmiş, araştırmanın örneklemini yaşları 7-16, sınıfları 1-11 arasında değişen toplam 100 öğrenci (kız=56; erkek=44) oluşturmaktadır. Verileri KINDL çocuklar için sağlıkla ilgili yaşam kalitesi ölçeğiyle toplanmış, verilerin çözümünde t istatistiği, varyans analizi, Kruskal-Wallis, Mann-Whitney U testi ve Pearson Çarpım Momentler Korelasyon tekniğinden yararlanılmıştır. Sonuçlar: Bulgular öğrencilerin cinsiyetlerine göre yaşam kalite düzeyleri arasında anlamlı fark olmadığını gösterirken, yaş, sınıf, yatış süreleri ve yatış kliniklerine göre yaşam kalite düzeyleri arasında anlamlı farkların olduğunu göstermiştir. Öğrencilerin yaş ve sınıf düzeyleri ile özsaygı ve okulla ilgili yaşam kalite düzeyleri ayrıca, hastanede yatış süreleri ile arkadaş konusundaki yaşam kalite düzeyleri arsında negatif ve anlamlı ilişkiler bulunurken, öğrencilerin hastanede yatış süreleri ile aileyle ilgili yaşam kalite düzeyleri arasında da pozitif ve anlamlı ilişkiler bulunmuştur.
Birinci Basamakta Çalışan Sağlık Personelinin Sağlıklı Yaşam Biçimi Davranışları ve Sağlıklı Davranış Geliştirme Niyetlerinin Değerlendirilmesi
Authors: DEMİR SAKA Selma , GÖZÜM Sebahat , DEMİR AVCI Yasemin
Published: June 2022

Amaç: Bu çalışma Antalya’da birinci basamak bünyesinde çalışan sağlık personelinin sağlıklı yaşam biçimi davranışlarını ve sağlıklı davranış geliştirme niyetlerini değerlendirmek amacıyla yapılmıştır. Yöntem: Tanımlayıcı türde olan araştırmamız Aralık 2017 ve Haziran 2018 tarihleri arasında Halk Sağlığı Hizmetleri Başkanlığı bünyesinde çalışan 257 sağlık personeli ile yapılmıştır. Veri toplama yöntemi olarak online anket hazırlanmıştır. Verilerin toplanmasında; sağlık personelinin sosyo-demografik özellikleri soru formu, 'Sağlıklı Yaşam Biçimi Davranışları-II Ölçeği (SYBDÖ II)' ve 'Sağlık Davranışı Değişim Aşamaları Değerlendirme Soru Formu' kullanılmıştır. Etik kurul ve kurum izni alınmıştır. Bulgular: Çalışmaya katılan sağlık personelinin yaş ortalaması 40.79±7.72’dir. Sağlık personelinin SYBDÖ II toplam puan ortalaması 140.41±23,53’tür. Sağlık personelinin sigara içmeyi bırakanların sigara içmeyen ve içenlere göre fiziksel aktivite puan ortalamaları daha yüksek bulunmuştur (F=4.433; p=013). Sağlık algısı yaşıtlarına göre iyi olan sağlık personelinin, sağlık algısı yaşıtları ile aynı ve kötü olanlara göre SYBDÖ II alt boyut puan ortalamaları arasında istatistiksel olarak anlamlı bir fark bulunmuştur (p<0.05). Alkol kullanmayan sağlık personelinin, alkol kullananlara göre sağlık sorumluluğu puan ortalaması daha yüksektir (t=1.996; p=0.047). Sonuç: Araştırmaya katılan sağlık personelinin sağlıklı yaşam biçimi davranışları iyi düzeyde bulunmuştur. Elde edilen sonuçlar doğrultusunda birinci basamakta çalışan sağlık personelinin sağlıklı yaşam davranışları göstermesi konusunda teşvik edilmesi, sağlığın geliştirilmesine olumlu katkı sağlayabilir.
Aplicación de la teoría de señales a la medición de desplazamiento de fluidos en una tubería – Sistema SIMTU
Authors: Moreno Ascanio Andersson Leonardo , Torres Hoyos Miguel Ángel , Cuesta Díaz Flavia , García Arango David Alberto
Published: June 2022

The application of the theory of signals to the measurement of fluid displacement shows how, through wireless signals, data can be transmitted in real time to an information system made to observe the changes that differ from said signal. The project is based on statistically measuring results of values transmitted through network devices; Likewise, it is a means of preventingfuture disasters, whether ecological or monetary. The idea of the general project is that by means of the fluids that pass and run through a pipe, they drive a propeller and this rotation allows a voltage to be generated thanks to a motor; this voltage will be transmitted from a wireless or wired device to a receiver in a computer; where the "SIMTu" information system will generate a view of the results obtained in the received data, these filesare generally numerical values and are established to givemeasurements and in this way generate adequate statistics for their previous study
Desarrollo de un sistema de información CRM que permita integrar el proceso de asesoría comercial en una empresa de seguros
Authors: Arley Vanegas Duvan , Tatiana Parias Jenifer , Muñoz Cortés Nancy del Socorro , Henao Villa César Felipe , García Arango David Alberto
Published: June 2022

This article consists of the description of the design andimplementation of a CRM information system that allowsintegrating the commercial consulting process in an insurance company, which takes all the concepts and shortcomings that arise in the daily tasks of the advisors. This project intends that users use it as a fundamental piece for the required functions of the business, providing them with effectiveness in fulfilling their tasks and goals. The main problem is that there are no technological software tools that allow advisors to managethe relationship with their clients, identify, attract or increase loyalty with their consumers, identifying new and potential clients. Based on the above, the development of the research raises the following question: How could a technological information system be developed that allows integrating the process of commercial advice in the field of insurance, allowing them to improve both in your customer service processes as in your personal income?
Implementación y estandarización de procesos de capacitación de servicio postventa de concesionarios para vehículos pesados
Authors: Alejandro Ríos Mario , Tatiana Parias Jenifer , Henao Villa Federico , García Arango David Alberto , Henao Villa Cesar Felipe
Published: June 2022

This paper pesents the implementation and standardizationof after-sales service training processes for automotive dealers with the help of the Bizagi method (BPMN), in the workshop area of a company in Medellín, through the analysis that was carried out during the process. that is provided in the area, conducting an interview of the current situation through field research, to determine the problems, their causes and effects; In addition, the difficulties focused on the lack of support areobserved through training for personal and work growth, then the biggest problems that affect the different activities and tasks of after-sales services are identified
Het berechten en bestraffen van Syriëstrijders
Authors: Van Deputte Daphne
Published: June 2022

Terreurorganisatie Islamitische Staat trok heel wat Europese jongeren aan. Velen van hen kwamen om, een deel keerde terug naar het land van herkomst en een andere groep verblijft nog steeds in het conflictgebied. Al jaren worstelen landen met de problematiek van berechting en bestraffing van deze Foreign Terrorist Fighters (FTF’s). De ernst van de misdrijven zorgt ervoor dat er diverse mogelijkheden zijn: lokaal berechten, berechten in het land van herkomst of een proces voor een hof of tribunaal. Naast de internationale regels omtrent jurisdictie en bestraffing van terreur, spelen ook emotionele en ethische overwegingen een rol. De internationale gemeenschap wil terroristen verantwoordelijk stellen voor hun daden en dit mits respect voor rule of law en mensenrechten, maar ook burgers verwachten dat misdadigers gestraft worden. Familieleden van Syriëgangers willen vaak dat de (klein)kinderen geholpen worden, terwijl experts het veiligheidsrisico in overweging nemen bij het afwegen van de diverse opties. Dit leidt tot een complexe situatie die dringend opgelost moet worden.
Mad or bad? Voorbij een binaire kijk op extremistisch geweld
Authors: Boelaert Astrid , Busch Christophe
Published: June 2022

In dit artikel wordt stilgestaan bij het complex samenspel van (f)actoren, met in het bijzonder aandacht voor psychische stoornissen, in het tot stand komen van extremistisch geweld en hoe deze in verhouding tot de intentie tot het plegen van dergelijk geweld kunnen worden begrepen. Via een complexiteitsbenadering en met inclusie van forensisch gedragswetenschappelijke kennis wordt zo een meer systemische kijk op het ontstaan van extremistisch geweld aangereikt.
Predicting Risk of Hypoglycemia in Patients With Type 2 Diabetes by Electronic Health Record–Based Machine Learning: Development and Validation (Preprint)
Authors: Yang Hao , Li Jiaxi , Liu Siru , Yang Xiaoling , Liu Jialin
Published: June 2022

BACKGROUND

Hypoglycemia is a common adverse event in the treatment of diabetes. To efficiently cope with hypoglycemia, effective hypoglycemia prediction models need to be developed.

OBJECTIVE

The aim of this study was to develop and validate machine learning models to predict the risk of hypoglycemia in adult patients with type 2 diabetes.

METHODS

We used the electronic health records of all adult patients with type 2 diabetes admitted to West China Hospital between November 2019 and December 2021. The prediction model was developed based on XGBoost and natural language processing. F1 score, area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA) were used as the main criteria to evaluate model performance.

RESULTS

We included 29,843 patients with type 2 diabetes, of whom 2804 patients (9.4%) developed hypoglycemia. In this study, the embedding machine learning model (XGBoost3) showed the best performance among all the models. The AUC and the accuracy of XGBoost are 0.82 and 0.93, respectively. The XGboost3 was also superior to other models in DCA.

CONCLUSIONS

The Paragraph Vector–Distributed Memory model can effectively extract features and improve the performance of the XGBoost model, which can then effectively predict hypoglycemia in patients with type 2 diabetes.
Features of the mucous barrier in functional bowel diseases and ulcerative colitis
Authors: Dorofeyev A.E. , Tkach S.M. , Dyadyk О.О. , Prikhodko V.M.
Published: June 2022

Background. The intestinal mucosal barrier may change under the influence of exogenous and endogenous factors. Changes in its physical and chemical characteristics are observed in patients with gastrointestinal diseases, such as irritable bowel syndrome, ulcerative colitis, Crohn’s disease, and with other pathologies, such as diabetes mellitus, food allergies, rheumatoid arthritis, etc. Also, the permeability of the intestinal wall was influenced by tight junctions, which are weakened due to eating disorders, psycho-emotional factors, and chemical agents. The purpose of the study was evaluating of changes in the mucosal barrier in patients with functional and inflammatory bowel diseases. Materials and methods. 270 patients with different subtypes of irritable bowel syndrome and 218 patients with ulcerative colitis were examined. Colonoscopy followed by a morphological assessment of biopsy specimens and immunohistochemical studies using markers of claudin 1 and 7, mucins 1, 2, 3, 4, 5AC, and trefoil factors 1–3 was performed in all patients. Results. A decrease in the level of tight junction proteins called claudins was observed in patients with functional bowel disease. Patients with irritable bowel syndrome associated with diarrhea had a lower level of claudin-1 only, while patients with mixed form had also a lower level of claudin-7. A decrease in the level of both secretory and membrane-bound mucins and an increase in the level of the trefoil factors were observed at the same time among the patients with ulcerative colitis which may indicate a dysregulation and a violation of the protective function of mucus. Conclusions. The pathogenesis of a violation of the protective function of the mucosa of functional and inflammatory bowel disease is different, which may determine approaches to the treatment of patients with such pathologies.
The fragility of interpersonal relationships evidenced in the pandemic period with COVID-19
Authors: Cunha Edinaura Rios , Oliveira Mariana Pimenta de , Costa Nelzir Martins , Balduino Angelo Ricardo
Published: June 2022

The pandemic with Covid-19 established a social chaos on the planet, which required extreme changes in order to contain the large-scale contamination of the disease. Social isolation, adopted as one of the restrictive measures, generated other problems with high repercussions in the indices of domestic violence, feminicide, divorces, among others, highlighting the fragility of interpersonal relationships and the consequences for society. The present study aims to present how interpersonal relationships were affected during social isolation. As methodology, the research was based on a literature review based on theorists such as Bauman (2001; 2004), Forbes (2010; 2019), in the approach about liquidity in contemporary relationships; in studies on the subject available in scientific and research platforms, college observatories and analysis of statistics about problems instaured from relational conflicts during the pandemic period. As a result, it became evident that sudden changes in the rhythm of life, such as residential confinement, contributed to increase the rates of domestic violence, consumption of alcoholic beverages, psycho-emotional diseases and divorce among couples. Evidence that human beings need to detach themselves from the liquidity and fluidity that contemporary immediacy adds to interpersonal relationships and reinforces the need to undertake more solid and effective relationships so that they can face crisis situations without destabilizing family ties and, thus, have more serenity and collaboration in solving challenges, such as the pandemic with Covid-19.
Satversmes atvērtība starptautiskajām cilvēktiesībām
Authors:   Latvijas Universitāte, Kučs Artūrs
Published: June 2022

This article explores the topic on interaction between fundamental rights protected in the Constitution of the Republic of Latvia (Satversme), international human rights and European Union law. The author reflects the evolution of the principle of openness in Satversme toward international human rights by analysing influence of international human rights law upon Latvia’s fundamental rights protection system through the course of history – in the interwar period, after the restoration of the independence and in adoption of fundamental rights chapter of Satversme. Further on, the author analyses the application of international human rights law and European Union law in the Constitutional Court’s jurisprudence and identifies controversial issues.
Datu otrreizēja izmantošana – jauni izaicinājumi vai jaunas iespējas?
Authors:   Latvijas Universitāte, Bitāns Agris
Published: June 2022

The article is dedicated to challenges regarding secondary use of personal medical data and social data. As recognised by European Commission, the digital transition should work for all, putting people first and opening new opportunities for business. According to latest Open Data Institute research, Latvia is placed in the middle amongst the EU countries regarding policy for secondary use of health data. Finish Act on the Secondary Use of Health and Social Data and FinData practical experience constitutes a good role model regarding secondary use of health and social data. Latvia has commenced drafting the law for secondary use of personal data, and there are several issues, which should be addressed in this draft law.
Vidusmēra un mazaizsargāta patērētāja koncepta modernizācija
Authors:   Latvijas Universitāte, Dāvida Zanda
Published: June 2022

Digitalisation has provided an opportunity to develop the technological practices such as dark patterns, manipulative, targeting and other personalized persuasion practices that exploit consumer’s digital vulnerability and asymmetry of digital power between parties, for example, an informational power imbalance. This paper seeks to demonstrate that, despite being technology-neutral and having a broad scope, the Unfair Commercial Practice Directive needs some legal update and upgrade to ensure a high level of consumer protection (in accordance with Article 12 of the Treaty on the Functioning of the European Union) also in the digital market.
Trešo personu atsevišķas tiesības un pienākumi prasības tiesvedībā
Authors:   Latvijas Universitāte, Ose Daina
Published: June 2022

Third parties is quite a significant institute of procedural law based on the principle of procedural economy and the duty to establish the truth in court. An essential feature of a third party’s participation in legal proceedings is the need for that person to protect his or her legal interests and to intervene in the dispute between the parties on his or her own initiative. A judge is not entitled to summon a party to a civil case on his or her own initiative, if the party to the dispute has not made such a request. The third party, without his or her independent claims, is one of the parties to the dispute in support of the case. When deciding on the admission or summoning of a third party, the judge must assess whether the boundaries of the subject of the claim and the claim allow the protection of the legal interest of the third party concerned. Economic interest and actual interest are not grounds for admitting or summoning a third party to a civil case.
Cēloņsakarības konstatēšana mākslīgā intelekta darbībā
Authors:   Latvijas Universitāte, Purmalis Ritvars
Published: June 2022

While there is still a debate at European Union level as to which of the known models of civil liability should be used to determine a person’s civil liability for damage caused by an artificial intelligence-driven system, particular attention should be directed at the issues relating to the “transparency” and “explainability” of the operation of artificial intelligence-driven system. The purpose of this article is to provide a brief insight into the importance of establishing the causal relationship between the way in which the inputs (various datasets) available for the artificial intelligence-driven system are used as a basis to reach a particular conclusion within its autonomous operation, and the importance of this matter within the context of recent legal policy updates.
Legalizēšanas nozieguma objekta De Lege Ferenda
Authors:   Latvijas Universitāte, Janums Juris
Published: June 2022

The article discusses the changes in the structure of the Laundering of the Proceeds from Crime in the Criminal Law as a legal norm, that has a blanket reference, after the implementation of the FATF recommendations in Latvia, especially paying attention to the object of Laundering of the Proceeds from Crime from the point of view of the Progressive criminal law school as of de lege ferenda, seeking to establish what the person is responsible for in the case of laundering crime. Thus, by taking a brief view at the findings of the Latvian criminal law theory on the object of a criminal offense and the protection of economic, fiscal and monetary interests in the Criminal Law in Latvia, the author finds that one of the constituent elements of a criminal offense – i.e., the object (protected interest) – theoretically de facto does not exist in the Laundering of the Proceeds from Crime offence. Thereby the principle of Nullum crimen nulla poena sine lege as provided in the Section 1 of the Criminal Law is not respected. At the end of the article, the author offers his solution to the established problem – it is to restore the previously stroked reference to the predicate crime in the description of the laundering crime, thus restoring the unbreakable link of money laundering crime with predicate crime, which would reveal to the law enforcer the legal interest protected by the Criminal Law.
Pieaugušu cilvēku ar lemtspējas ierobežojumiem tiesības administratīvajā procesā
Authors:   Latvijas Universitāte, Olsena Solvita
Published: June 2022

The paper presents the current legal regulation of rights of persons with limited capacity in administrative procedure and suggests considering amendments to secure the implementation of norms stated in the UN Convention on the Rights of Persons with Disabilities. First, the general framework of legal capacity in Latvian law is described. Second, the procedural rights of persons with limited legal capacity in the administrative procedure in line with general regulations in Civil Law are analysed. Third, the rights of persons with limited capacity stated in Articles 12 and 13 of the Convention on the Rights of Persons with Disabilities are characterised. Finally, the development of amendments to the administrative procedure laws required for the protection of persons with limited capacity is suggested.
Cilvēka personas brīvība un kopīgais labums Žaka Maritēna filosofijas skatījumā = The Human Person’s Freedom and the Common Good in Jacques Maritain’s Philosophy
Authors: Klotiņš Jurģis
Published: June 2022

In his essays under the title “The Person and the Common Good” (the French edition 1947), Jacques Maritain extensively discussed the mutual relation and interdependence between a human person and a political community. The human person is a part of a political community and inferior to it, for he or she receives basic human goods from the common good, which itself is constituted by human persons. Nevertheless, a human person is also superior to the political community due to an ultimate fulfilment of human existence in direct relationship to God and regarding matters related to the philosophical categories such as truth, good and beauty. If the human person’s freedom to strive for these transcendental goods is respected on behalf of the political community, the common good can be properly maintained and continues to serve the community. Maritain’s position contains practical implications for the contemporary discussions of political philosophy on freedom of conscience and religious freedom, and freedom of expression.
My China Story
Authors: Pildegovičs Pēteris
Published: June 2022

In this narrative, written in the form of a diary, its author Pēteris Pildegovičs shares with the reader the observations during his post as the first Latvian diplomat in China, as well as the impressions gained during his work at Xinhua News Agency, where he has been the only employee from our country to date. The author also introduces the reader to the experience of his extensive travels throughout China, often referring to countless conversations with the Chinese of all generations and social backgrounds.
Evolución del pensamiento organizacional: una mirada de las teorías de la organización clásica hacia las teorías pos burocráticas y pos modernas
Authors: Sepúlveda Aguirre Jovany Arley , Virviescas Peña John Anderson , Arboleda Jaramillo Carlos Augusto , Salazar García Hernán Alonso
Published: June 2022

La investigación analiza los conceptos de las teorías organizacionales y da una mirada a la organización como una forma social en la que se concibe esta como uno de los tipos específicos de orden social, desde el análisis de las explicaciones que desarrollan las diferentes teorías de la organización, entre ellas, las burocráticas modernas y las posburocráticas posmodernas. Este análisis permite poner en evidencia la trazabilidad de la evolución de las organizaciones y la manera en cómo se han ido enriqueciendo, lo cual permite tener más herramientas para conocer y entender mejor a las organizaciones y determinar el enfoque que ajusta a las estructuras para enfrentar las situaciones y el entorno cambiante.
¿Es suficiente la voluntad política para que tenga éxito el Presupuesto Participativo?
Authors: Pineda Nebot Carmen , Pires Valdemir
Published: June 2022

El objetivo de este trabajo es confirmar empíricamente, por medio del análisis de los municipios con Presupuesto Participativo en la Comunidad Valenciana después de las elecciones municipales de 2015 y 2019, que la voluntad política es un elemento fundamental para la puesta en marcha y la continuidad de las experiencias de Presupuesto Participativo. La metodología utilizada ha combinado técnicas de investigación social cualitativas y cuantitativas. Los resultados han demostrado que la voluntad política es una variable importante para la puesta en marcha de las experiencias, pero que, para su continuidad, puede ser un problema sino se incorporan otros compromisos. Sin embargo, no es una política global de ningún partido político, aunque la participación ciudadana es una política más integrada en los partidos de la izquierda, siendo estos los que ponen en marcha más experiencias de Presupuesto Participativo.
OPTIMALISASI KINERJA LEMBAGA AMIL ZAKAT MELALUI STANDAR MUTU ISO 9001
Authors: Majid Nurkholish
Published: June 2022

Quality management in organizations becomes a necessity to improve performance and quality standards that have been set. Quality standards can be achieved when the organization has obtained ISO 9001 certification. This study aims to examine how the application of ISO 9001 quality standards in zakat and waqf institutions and how organizational performance can be optimized through the study of several journal articles related to ISO 9001 implementation and its role in improving performance in zakat and wakaf institutions which are expected to be amil zakat and wakaf institutions to be more optimal, efficient, quality and standardized. This study uses qualitative research, with primary and secondary data sources that fit this study. The results showed that the implementation of a quality management system in accordance with ISO 9001 standards in zakat institutions was able to produce performance improvements that were measured through the satisfaction of muzakki and all levels of stakeholders as well as financial aspects and sustainable business processes. muzakki is able to encourage improvement in organizational governance that is good corporate governance.Â Manajemen mutu dalam organisasi menjadi kebutuhan guna meningkatkan kinerja dan standar mutu yang telah ditetapkan. Standar mutu dapat dicapai ketika organisasi telah memperoleh sertifikasi ISO 9001. Penelitian ini bertujuan untuk mengkaji bagaimana penerapan standar mutu ISO 9001 dalam lembaga zakat dan wakaf serta bagaimana kinerja organisasi dapat dioptimalkan melalui kajian beberapa artikel jurnal terkait dengan implementasi ISO 9001 dan perannya dalam peningkatan kinerja pada lembaga zakat dan wakaf yang diharapkan lembaga amil zakat dan wakaf menjadi lebih optimal, efisiensi, yang berkualitas dan terstandar. Penelitian ini menggunakan penelitian kualitatif, dengan sumber data primer dan Skunder yang sesuai penelitian ini. Hasil penelitian menunjukkan bahwa penerapan sistem manajemen mutu sesuai dengan standar ISO 9001 dalam lembaga zakat mampu menghasilkan peningkatan kinerja yang diukur melalui kepuasan muzakki dan seluruh jajaran stakeholder serta aspek finansial serta proses bisnis yang berkelanjutan, Lembaga zakat yang memfokuskan pada stakeholder serta peningkatan layanan kepada mustahik dan muzakki mampu mendorong peningkatan tata keola organisasi yang bersifat good corporate governance.
ANALISIS PENGARUH ZAKAT TERHADAP PENINGKATAN PENDAPATAN MUSTAHIQ (Studi Kasus Di Rumah Zakat Kantor Cabang Solo)
Authors: Efendi Mansur , Ardhiastuti Yuni
Published: June 2022

Rumah Zakat Solo Branch Office in "Senyum Mandiri" program based on mustahiq empowerment has distributed zakat funds to mustah}iq as additional capital assistance. The distribution of zakat to the productive sector is expected to affect the income of mustahiq, or even change the formation of society from mustahiq becomes muzakki. However, it is known that the realization of zakat acceptance is still far from its potential. This may be due to the lack of muzakki belief that zakat has no effect on the income of mustahiq. This study was conducted to determine the distribution of zakat funds affects the increase of mustahiq income in Rumah Zakat Solo Branch Office. The results showed that zakat influences positively to increase mustahiq income in Rumah Zakat Solo Branch Office. This is shown in the results on the data with the help of software Statistical Product and Service Solutions (SPSS)/SPSS Statistics version 22.0, namely on the value of thitung is 4,944 in which it is greater than the value of ttable (2,012). Meanwhile the value of significance is 0,000 in which it is smaller than alpha (0,05). The level of relationship between variables is at the medium level indicated by the correlation number (Pearson Correlation) of 0,593. The value of R2 is 0,338 which indicates that the distribution of zakat (X) gives the effect around 33,8% to the increase of mustah}iq income (Y), while 66,2% is influenced by other variables which are not included in this research.Rumah Zakat Kantor Cabang Solo dalam program "Senyum Mandiri" berdasarkan program pemberdayaan mustahiq, telah mendistribusikan dana zakat ke mustahiq sebagai bantuan modal tambahan. Distribusi zakat ke sektor produktif diharapkan dapat memengaruhi pendapatan mustahiq, atau bahkan mengubah pandangan masyarakat dari mustahiq menjadi muzakki. Namun, diketahui bahwa realisasi penerimaan zakat masih jauh dari potensinya. Ini mungkin karena kurangnya kepercayaan muzakki bahwa zakat tidak berpengaruh pada pendapatan mustahiq. Penelitian ini dilakukan untuk mengetahui distribusi dana zakat mempengaruhi peningkatan pendapatan mustahiq di Rumah Zakat Kantor Cabang Solo.Hasil penelitian menunjukkan bahwa zakat berpengaruh positif terhadap peningkatan pendapatan mustahiq di Rumah Zakat Kantor Cabang Solo. Hal ini ditunjukkan pada hasil pada data dengan bantuan perangkat lunak Statistik Produk dan Layanan Solusi (SPSS) / SPSS Statistik versi 22.0, yaitu pada nilai terhitung adalah 4,944 di mana itu lebih besar dari nilai ttable (2,012). Sementara nilai signifikansi adalah 0,000 yang lebih kecil dari alpha (0,05). Tingkat hubungan antar variabel berada pada level sedang yang ditunjukkan oleh angka korelasi (Korelasi Pearson) sebesar 0,593. Nilai R2 adalah 0,338 yang menunjukkan bahwa distribusi zakat (X) memberikan efek sekitar 33,8% terhadap peningkatan mustahiq pendapatan (Y), sedangkan 66,2% dipengaruhi oleh variabel lain yang tidak termasuk dalam penelitian ini.
IMPLEMENTASI PENGELOLAAN DANA WAKAF UANG DI BAITUL MAAL WAT TAMWIL (BMT) MANDIRI SEJAHTERA
Authors: Rohman Ahmad Habibur , Wardana Guntur Kusuma
Published: June 2022

The purpose of this research is knowing of the management cash wakaf at BMT Mandiri Sejahtera. The method used is a qualitative method with a descriptive approach. This research was conducted at BMT Mandiri Sejahtera, Karangcangkring Dukun Gresik . BMT Mandiri Sejahtera is a non-bank Islamic financial institution in the form a cooperative that combines two financial, namely Baitul Maal and the Baitul Tamwil. The results of the study indicate that the management of cash waqf is managed based on benefit and is in accordance with the value of benefits by waqf assets. The management of cash waqf that is implemented at BMT Mandiri Sejahtera Karangcangkring Gresik is one of which is manifested of BMT customer who have the awareness of waqf. Other then that at BMT Mandiri Sejahtera Karangcangkring Gresik by providing capital loans to customers of BMT Mandiri Sejahtera which results are divided 60% to be distributed the name of cash waqf, where the remaining 40% is put back in the waqf funds for inflation adjustment.

Tujuan dari penelitian ini adalah untuk mengetahui pengelolaan wakaf tunai di BMT Mandiri Sejahtera. Metode yang digunakan adalah metode kualitatif dengan pendekatan deskriptif. Penelitian ini dilakukan di BMT Mandiri Sejahtera, Karangcangkring Dukun Gresik. BMT Mandiri Sejahtera adalah lembaga keuangan syariah non bank berbentuk koperasi yang menggabungkan dua keuangan, yaitu Baitul Maal dan Baitul Tamwil. Hasil penelitian menunjukkan bahwa pengelolaan wakaf tunai dikelola berdasarkan manfaat dan sesuai dengan nilai manfaat aset wakaf. Pengelolaan wakaf tunai yang dilaksanakan di BMT Mandiri Sejahtera Karangcangkring Gresik salah satunya adalah wujud nasabah BMT yang memiliki kesadaran wakaf. Selain itu di BMT Mandiri Sejahtera Karangcangkring Gresik dengan memberikan pinjaman modal kepada nasabah BMT Mandiri Sejahtera yang hasilnya dibagi 60% untuk dibagikan atas nama wakaf tunai, dimana 40% sisanya dimasukkan kembali ke dana wakaf untuk penyesuaian inflasi.
SURVEI TENTANG FAKTOR-FAKTOR PENENTU KEPATUHAN MEMBAYAR ZAKAT DI MASA PANDEMI
Authors: Aligarh Frank
Published: June 2022

The Covid 19 pandemic has slowed economic growth. The addition of the new poor and the increasing number of unemployed people made the government's burden in providing assistance even heavier. Zakat as an alternative to financial instruments is expected to be an alternative to this problem. However, the potential for zakat must be improved. The main objective of this study is to examine the determinants of zakat paying compliance. This study uses religiosity, trust, income, and gender as predictor variables. This study uses a survey method in data collection. A total of 230 questionnaires were distributed to respondents in Muslim-majority areas (namely Surakarta City), of which 198 were usable. This study uses Structural Equation Modeling to analyze data. The results show that all hypotheses are supported.
 
Pandemi Covid 19 telah membuat pertumbuhan ekonomi menjadi melambat. Bertambahnya orang miskin baru dan semakin banyaknya pengangguran membuat beban pemerintah dalam memberikan bantuan semakin berat. Zakat sebagai alternatif instrumen keuangan diharapkan menjadi alternatif persoalan tersebut. Walaupun demikian potensi zakat masih harus ditingkatkan. Tujuan utama penelitian ini adalah untuk menguji faktor-faktor penentu kepatuhan membayar zakat. Penelitian ini menggunakan religiusitas, kepercayaan, pendapatan, dan gender sebagai variabel prediktor. Penelitian ini menggunakan metode survei dalam pengumpulan data. Sebanyak 230 kuesioner dibagikan kepada responden di wilayah mayoritas Muslim (yaitu Kota Surakarta), dari jumlah tersebut, 198 kuesioner yang dapat digunakan. Penelitian ini menggunakan Structural Equation Modelling untuk menganalisis data. Hasil menunjukan bahwa seluruh hipotesis terdukung.