bluuebunny/crossref_metadata_2025 huggingface dataset:
Can Dispersion Forces Govern Aromatic Stacking in an Organic Solvent?
Authors: Yang Lixu , Brazier John B. , Hubbard Thomas A. , Rogers David M. , Cockroft Scott L.
Published: December 2015

Experimental support for the dominance of van der Waals dispersion forces in aromatic stacking interactions occurring in organic solution is surprisingly limited. The size‐dependence of aromatic stacking in an organic solvent was examined. The interaction energy was found to vary by about 7.5 kJ mol−1 on going from a phenyl–phenyl to an anthracene–pyrene stack. Strikingly, the experimental data were highly correlated with dispersion energies determined using symmetry‐adapted perturbation theory (SAPT), while the induction, exchange, electrostatic, and solvation energy components correlated poorly. Both the experimental data and the SAPT‐dispersion energies gave high‐quality correlations with the change in solvent accessible area upon complexation. Thus, the size‐dependence of aromatic stacking interactions is consistent with the dominance of van der Waals dispersion forces even in the presence of a competing polarizable solvent.
O2 Activation and Double CH Oxidation by a Mononuclear Manganese(II) Complex
Authors: Deville Claire , Padamati Sandeep K. , Sundberg Jonas , McKee Vickie , Browne Wesley R. , McKenzie Christine J.
Published: December 2015

A MnII complex, [Mn(dpeo)2]2+ (dpeo=1,2‐di(pyridin‐2‐yl)ethanone oxime), activates O2, with ensuing stepwise oxidation of the methylene group in the ligands providing an alkoxide and ultimately a ketone group. X‐ray crystal‐structure analysis of an intermediate homoleptic alkoxide MnIII complex shows tridentate binding of the ligand via the two pyridyl groups and the newly installed alkoxide moiety, with the oxime group no longer coordinated. The structure of a MnII complex of the final ketone ligand, cis‐[MnBr2(hidpe)2] (hidpe=2‐(hydroxyimino)‐1,2‐di(pyridine‐2‐yl)ethanone) shows that bidentate oxime/pyridine coordination has been resumed. H218O and 18O2 labeling experiments suggest that the inserted O atoms originate from two different O2 molecules. The progress of the oxygenation was monitored through changes in the resonance‐enhanced Raman bands of the oxime unit.
Copper‐Catalyzed Borylative Cross‐Coupling of Allenes and Imines: Selective Three‐Component Assembly of Branched Homoallyl Amines
Authors: Rae James , Yeung Kay , McDouall Joseph J. W. , Procter David J.
Published: December 2015

A copper‐catalyzed three‐component coupling of allenes, bis(pinacolato)diboron, and imines allows regio‐, chemo‐, and diastereoselective assembly of branched α,β‐substituted‐γ‐boryl homoallylic amines, that is, products bearing versatile amino, alkenyl, and borane functionality. Alternatively, convenient oxidative workup allows access to α‐substituted‐β‐amino ketones. A computational study has been used to probe the stereochemical course of the cross‐coupling.
Avoiding Carbothermal Reduction: Distillation of Alkoxysilanes from Biogenic, Green, and Sustainable Sources
Authors: Laine Richard M. , Furgal Joseph C. , Doan Phi , Pan David , Popova Vera , Zhang Xingwen
Published: December 2015

The direct depolymerization of SiO2 to distillable alkoxysilanes has been explored repeatedly without success for 85 years as an alternative to carbothermal reduction (1900 °C) to Simet, followed by treatment with ROH. We report herein the base‐catalyzed depolymerization of SiO2 with diols to form distillable spirocyclic alkoxysilanes and Si(OEt)4. Thus, 2‐methyl‐2,4‐pentanediol, 2,2,4‐trimethyl‐1,3‐pentanediol, or ethylene glycol (EGH2) react with silica sources, such as rice hull ash, in the presence of NaOH (10 %) to form H2O and distillable spirocyclic alkoxysilanes [bis(2‐methyl‐2,4‐pentanediolato) silicate, bis(2,2,4‐trimethyl‐1,3‐pentanediolato) silicate or Si(eg)2 polymer with 5–98 % conversion, as governed by surface area/crystallinity. Si(eg)2 or bis(2‐methyl‐2,4‐pentanediolato) silicate reacted with EtOH and catalytic acid to give Si(OEt)4 in 60 % yield, thus providing inexpensive routes to high‐purity precipitated or fumed silica and compounds with single Si−C bonds.
The Electrochemical Synthesis of Polycationic Clusters
Authors: Schulz Christopher , Daniels Jörg , Bredow Thomas , Beck Johannes
Published: December 2015

As a new method for the synthesis of chalcogen polycationic clusters, the electrochemical dissolution of elemental tellurium in ionic liquids (IL) or in liquid SO2 is presented. ILs used are ethylmethylimidazolium triflate [OTf]− and tetraalkylammonium triflylimide [NTf2]−. Tristriflylmethanide [CTf3]− was used as [BuMeIm][CTf3] as the electrolyte in SO2. This allowed for the isolation of [Te4][CTf3]2, [Te6][OTf]4, and [Te8][NTf2]2 containing the square [Te4]2+, the prismatic [Te6]4+, and the novel barrelane‐shaped [Te8]2+. The compounds are novel compositions as they do not contain the usual halometalate anions, but rather common weakly coordinating anions. The 125Te NMR spectrum of an IL solution containing [Te8]2+ features only one broad signal at 2700 ppm. DFT calculations show that slight concerted displacements within the [Te8]2+ cluster lead to a fluxional molecular structure and a fast valence isomerism with a very low activation barrier of about 8 kJ mol−1.
A Usual G‐Protein‐Coupled Receptor in Unusual Membranes
Authors: Chawla Udeep , Jiang Yunjiang , Zheng Wan , Kuang Liangju , Perera Suchithranga M. D. C. , Pitman Michael C. , Brown Michael F. , Liang Hongjun
Published: December 2015

G‐protein‐coupled receptors (GPCRs) are the largest family of membrane‐bound receptors and constitute about 50 % of all known drug targets. They offer great potential for membrane protein nanotechnologies. We report here a charge‐interaction‐directed reconstitution mechanism that induces spontaneous insertion of bovine rhodopsin, the eukaryotic GPCR, into both lipid‐ and polymer‐based artificial membranes. We reveal a new allosteric mode of rhodopsin activation incurred by the non‐biological membranes: the cationic membrane drives a transition from the inactive MI to the activated MII state in the absence of high [H+] or negative spontaneous curvature. We attribute this activation to the attractive charge interaction between the membrane surface and the deprotonated Glu134 residue of the rhodopsin‐conserved ERY sequence motif that helps break the cytoplasmic “ionic lock”. This study unveils a novel design concept of non‐biological membranes to reconstitute and harness GPCR functions in synthetic systems.
Synthesis of Multiply Substituted Polycyclic Aromatic Hydrocarbons by Iridium‐Catalyzed Annulation of Ring‐Fused Benzocyclobutenol with Alkyne through C−C Bond Cleavage
Authors: Yu Jiajia , Yan Hong , Zhu Chen
Published: December 2015

The first iridium‐catalyzed intermolecular cyclization between alkynes and ring‐fused benzocyclobutenols (RBCB) through C−C bond cleavage is described. A variety of elusive polycyclic aromatic hydrocarbons (PAHs) with multiple substituents are obtained in good yields under mild conditions. This procedure provides a unique and expeditious tool for the synthesis of PAHs.
Evaluation of solid phase extraction efficiency of functionalized biochar for polyphenols from Punica granatum
Authors: Yadav Vineet , Shrivastava Pooja , Deshmukh Yogita , Shanker Karuna , Khare Puja
Published: December 2015

The biochars functionalized with polyethylimine (BPE), orthosilicate and polyaniline were evaluated for solid phase extraction of pomegranate phenolics, namely gallic acid, rutin, ellagic acid, naringin, quercetin, apigenin and kaempferol. Characterization of composites of biochar for morphology, functional group and elemental composition has been done. Solid phase extraction cartridges packed with these composites were used for extraction. Most of these biochar composites attained nano‐sized porous structure. Functional group analysis suggests that oxygenated groups of biochar were interacted with electrophilic primary amines and polysilane chain of polyethylimine and orthosilicate, respectively. The formation of biochar‐polyaniline composite occurred through emeraldine base. All composites exhibited good retention capacity for all phenolics except kaempferol. BPE composites were found suitable for recovery of ellagic acid at present solvent system (aqueous methanol). The process was optimized by a quadratic model suggesting the pre‐concentration (60–95%) of ellagic acid (quadratic polynomial relationship, r2 = 1.00). Breakthrough curves were derived for the ellagic acid, which provide the information of retention equilibrium volume, column capacity and recovery of ellagic acid for the BPE packed solid phase extraction cartridges. © 2015 Curtin University of Technology and John Wiley & Sons, Ltd.
Ubiquitous Chromatin Opening Elements (UCOEs) effect on transgene position and expression stability in CHO cells following methotrexate (MTX) amplification
Authors: Betts Zeynep , Dickson Alan J.
Published: December 2015

The requirement for complex therapeutic proteins has resulted in mammalian cells, especially CHO cells, being the dominant host for recombinant protein manufacturing. In creating recombinant CHO cell lines, the expression vectors integrate into various parts of the genome leading to variable levels of expression and stability of protein production. This makes mammalian cell line development a long and laborious process. Therefore, with the intention to accelerate process development of recombinant protein production in CHO systems, UCOEs are utilized to diminish instability of production by maintaining an open chromatin surrounding in combination with MTX amplification. Chromosome painting and FISH analysis were performed to provide detailed molecular evaluation on the location of amplified genes and its relationship to the productivity and stability of the amplified cell lines. In summary, cell lines generated with vectors containing UCOEs retained stable GFP expression with MTX present (but instability was observed in the absence of MTX). UCOE cell lines displayed a higher frequency of integration into >1 chromosome than non‐UCOE group. Cell populations were more homogenous in terms of transgene location at the end of Long‐term culture (LTC). Overall our findings suggest variation in eGFP fluorescence may be attributed to changes in transgene integration profile over LTC.
Bioactivity‐based ultra‐performance liquid chromatography‐coupled quadrupole time‐of‐flight mass spectrometry for NF‐κB inhibitors identification in Chinese Medicinal Preparation Bufei Granule
Authors: Qingxin Cui , Min Fu , Mengge Zhou , Nianwei Chang , Ye Pan , Min Jiang , Zengtao Sun , Gang Bai
Published: December 2015

Traditional Chinese medicine (TCM) preparations have become effective treatments for many diseases. However, their active ingredients are still uncertain and difficult to identify. In this study, we propose a strategy that integrates ultra‐performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry (UPLC/Q‐TOF‐MS) and bioactive (NF‐κB inhibitor) luciferase reporter assay systems for the rapid determination of various anti‐inflammatory compounds of TCM preparations. In this way, Bufei Granule (BFG), a TCM preparation used for the clinical therapy of asthma, was analyzed by the two ways of component identification and activity detection. Potential anti‐inflammatory constituents were screened by NF‐κB activity assay systems and simultaneously identified according to the mass spectrometry data. Three structural types of NF‐κB inhibitors (caffeic acid derivatives, flavonoids and Pentacyclic triterpenes) were characterized. Further cytokine detection confirmed the anti‐inflammatory effects of the potential NF‐κB inhibitors. Compared with conventional chromatographic separation and inhibitory activity detection, integrating UPLC/Q‐TOF‐MS identification and virtual validation was more convenient and more reliable. This strategy clearly demonstrates that MS data‐based fingerprinting is a meaningful tool not only in identifying constituents in complex matrix but also in directly screening for powerful trace ingredients in TCM preparations. Copyright © 2016 John Wiley & Sons, Ltd.
Serum leptin, C‐reactive protein, and cancer mortality in the NHANES III
Authors: Wulaningsih Wahyu , Holmberg Lars , Ng Tony , Rohrmann Sabine , Van Hemelrijck Mieke
Published: December 2015

Adipokines, such as leptin, may affect cancer through its link with inflammation and obesity. We investigated the association between leptin, C‐reactive protein, and risk of cancer death while accounting general and abdominal obesity. From the Third National Health and Examination Survey (NHANES III), we selected 5957 adult men and women with baseline measurements of serum leptin and CRP. Multivariable Cox regression was used to assess leptin and CRP levels (low, moderate, high) in relation to risk of cancer death. Stratification analyses were performed for obesity as defined by body mass index (BMI) and waist circumference. Fine and Gray regression was performed to account for death from cardiovascular disease and other causes as competing events. A total of 385 participants died of cancer during a mean follow‐up of 18 years. After adjusting for BMI and waist circumference, an inverse association with log‐transformed leptin was found for women, with a hazard ratio (HR) of 0.81 (95% confidence interval [CI]: 0.51–1.30) and 0.40 (95% CI: 0.24–0.68) for moderate and high compared to low levels of leptin, respectively; Ptrend = 0.0007). No association for leptin was observed in men, but higher CRP corresponded to increased risk of dying from cancer (HR: 2.98; 95% CI: 1.57–5.64 for the highest vs. lowest categories of CRP). Similar associations were observed with competing risk analysis also adjusted for BMI and waist circumference. Contrasting associations of serum leptin and CRP with cancer mortality may indicate sex‐specific biological or environmental pathways linking obesity and cancer in men and women which warrant mechanistic investigations.
Lignin Refinery: Towards the Preparation of Renewable Aromatic Building Blocks
Authors: Graglia Micaela , Kanna Narasimharao , Esposito Davide
Published: December 2015

With its wide availability and its low cost, lignocellulosic biomass represents a very convenient and sustainable alternative to fossil fuels for the preparation of energy, materials, and chemical building blocks. While processes for cellulose and hemicellulose conversion into valuable products are already advanced, adding value to lignin is still a challenge, due to its complex structure and its relatively high stability towards a variety of chemical transformations. The pathway for the valorization of lignin from biomass often includes an initial extraction step, which in some cases can affect the native structure of the lignin backbone. At this stage, a further catalytic depolymerization step can follow, leading to the production of bio‐based small aromatic building blocks. In this review we describe the most important lignin extraction methods applied in industry (Kraft, Sulfite and Soda processes) as well as more recent processes based on so‐called organosolv and ionosolv protocols. In addition, the most important approaches for the heterogeneous catalytic depolymerization of lignin are critically discussed.
Active‐Site Engineering Expands the Substrate Profile of the Basidiomycete l‐Tryptophan Decarboxylase CsTDC
Authors: Kalb Daniel , Gressler Julia , Hoffmeister Dirk
Published: December 2015

Aromatic l‐amino acid decarboxylases (AADCs) catalyze the release of CO2 from proteinogenic and non‐proteinogenic l‐amino acid substrates and are involved in pathways that biosynthesize neurotransmitters or bioactive natural products. In contrast to AADCs from animals and plants, fungal AADCs have received very little attention. Here, we report on the in vitro characterization of heterologously produced Ceriporiopsis subvermispora AADC, now referred to as CsTDC, which is the first characterized basidiomycete AADC. This study identified the enzyme as a decarboxylase that is strictly specific for l‐tryptophan and 5‐hydroxy‐l‐tryptophan. The tdc gene was subjected to saturation mutagenesis so as to vary the key active site residue, Gly351. Aliphatic amino acid residues, l‐serine, or l‐threonine at position 351 added l‐tyrosine and 3,4‐dihydroxy‐l‐phenylalanine (l‐DOPA) decarboxylase activity while retaining stereospecificity and l‐tryptophan decarboxylase activity.
Developing Agency for Equity‐Minded Change
Authors: Felix Eric R. , Bensimon Estela Mara , Hanson Debbie , Gray James , Klingsmith Libby
Published: December 2015

This chapter highlights the use of the Equity Scorecard with the Community College of Aurora. The Equity Scorecard is a theory‐based strategy that assists community colleges in embedding equity into their institutional norms, practices, and policies.
Call to Action: Embracing an Inclusive LGBTQ Culture on Community College Campuses
Authors: Taylor Jason L.
Published: December 2015

Many community colleges are unwelcoming to LGBTQ students and this chapter provides practical suggestions to community college leaders to develop a more inclusive campus culture.
Do Financial Aid Policies Unintentionally Punish the Poor, and What Can We Do About It?
Authors: Campbell Courtney A. , Deil‐Amen Regina , Rios‐Aguilar Cecilia
Published: December 2015

This chapter argues that, despite intentions, the way federal financial aid policy is constructed and currently administered can have negative consequences for poor community college students.
Undocumented Students at the Community College: Creating Institutional Capacity
Authors: Valenzuela Jéssica I. , Perez William , Perez Iliana , Montiel Gloria Itzel , Chaparro Gabriel
Published: December 2015

This chapter introduces Institutional Undocu‐Competence (IUC), an institutional capacity framework emerging from a critical analysis of cultural competence, aimed to inform community colleges’ efforts to better support the growing undocumented student population.
Esterification of Free Fatty Acids Derived from Waste Cooking Oil with Octanol: Process Optimization and Kinetic Modeling
Authors: Chowdhury Avisha , Sarkar Debasish , Mitra Debarati
Published: December 2015

The synthesis of lubricant‐grade ester using waste cooking oil (WCO) as the primary feedstock is characterized in detail and optimized. WCO was initially hydrolyzed using Candida rugosa lipase to convert triglycerides into free fatty acids (FFA). Subsequently, the FFA were esterified with octanol by a heterogeneous catalytic reaction in batch mode. Both the hydrolysis and esterification steps were optimized in terms of relevant process parameters, employing the well‐known response surface methodology. The final product was characterized by Fourier transform infrared and nuclear magnetic resonance spectroscopy. Moreover, a pseudo‐homogeneous, second‐order kinetic model was proposed and validated with respect to the transient conversion data for the esterification reaction under optimum operating conditions. The overall output of the present study is highly useful in the design and development of large‐scale industrial flow reactors to produce biolubricant components using a domestic waste material as feedstock.
ChemInform Abstract: Reaction of Laser‐Ablated Uranium and Thorium Atoms with H2Se: A Rare Example of Selenium Multiple Bonding.
Authors: Vent‐Schmidt Thomas , Andrews Lester , Thanthiriwatte K. Sahan , Dixon David A. , Riedel Sebastian
Published: December 2015

H2ThSe (I) and H2USe (II) are obtained by the reaction of laser‐ablated U and Th with a ≈1:1:1 molar mixture of H2Se, HDSe, and D2Se under cryogenic conditions (CsI window as substrate, 10 K).
ChemInform Abstract: Thermoelectric Properties of Ba1.9Ca2.4Mg9.7Si7: A New Silicide Zintl Phase with the Zr2Fe12P7 Structure Type.
Authors: Silsby Kurt , Sui Fan , Ma Xiaowei , Kauzlarich Susan M. , Latturner Susan E.
Published: December 2015

Large crystals of Ba1.9Ca2.4Mg9.7Si7 and the compound Ba1.2Sr0.9Mg11.9Ge7 are prepared from the elements in Mg/Al flux (stainless steel crucibles, 950 °C for 10 h and 750 °C for 24 h).
ChemInform Abstract: Synthesis and Characterization of the Divalent Samarium Zintl‐Phases SmMg2Bi2 and SmMg2Sb2.
Authors: Ramirez D. , Gallagher A. , Baumbach R. , Siegrist T.
Published: December 2015

Single crystals of LnMg2Bi2 (Ln: Yb, Eu, Sm) and SmMg2Sb2 are prepared from elemental Ln in a reactive Mg/Bi or Mg/Sb flux (molar ratio of Mg:Bi(Sb):Ln = 25:5:1, 1000 °C, 20 h).
ChemInform Abstract: Polymorphism and Second Harmonic Generation in a Novel Diamond‐Like Semiconductor: Li2MnSnS4.
Authors: Aitken Jennifer A. , et al.
Published: December 2015

Single crystals of two modifications of the title compound are obtained from the solid state reaction of stoichiometric mixtures of Li2S, Mn, Sn, and sulfur (graphite crucible in a sealed silica tube, 800 °C, 30 h).
ChemInform Abstract: From WCl6 to WCl2: Properties of Intermediate Fe—W—Cl Phases.
Authors: Mos Agnieszka , Castro Cristina , Indris Sylvio , Stroebele Markus , Fink Reinhold F. , Meyer Hans‐Juergen
Published: December 2015

Ongoing reduction of WCl6 by elemental Fe intercalation successively results in the compounds FexWCl6, FeW2Cl10, Fe2W2Cl10, (Fe,W)1‐xCl2, and FeW6Cl14.
ChemInform Abstract: Single Cyanide‐Bridged Mo(W)/S/Cu Cluster‐Based Coordination Polymers: Reactant‐ and Stoichiometry‐Dependent Syntheses, Effective Photocatalytic Properties.
Authors: Zhang Jinfang , Wang Chao , Wang Yinlin , Chen Weitao , Cifuentes Marie P. , Humphrey Mark G. , Zhang Chi
Published: December 2015

Single cyanide‐bridged Mo(W)/S/Cu cluster‐based compounds are synthesized by varying the starting materials and their molar ratios, and characterized by single crystal XRD.
ChemInform Abstract: Copper‐Catalyzed Enantioselective Allylic Cross‐Coupling with Alkylboranes.
Authors: Hojoh Kentaro , Shido Yoshinori , Nagao Kazunori , Mori Seiji , Ohmiya Hirohisa , Sawamura Masaya
Published: December 2015

Allyl chlorides undergo copper‐catalyzed SN2‐type enantioselective substitution reactions with alkylboranes in the presence of axially chiral bisphosphines.
ChemInform Abstract: Enantioselective Synthesis of Dialkylated α‐Hydroxy Carboxylic Acids Through Asymmetric Phase‐Transfer Catalysis.
Authors: Duan Shaobo , Li Sanliang , Ye Xinyi , Du Nuan‐Nuan , Tan Choon‐Hong , Jiang Zhiyong
Published: December 2015

The enantioselective alkylation of 5H‐oxazol‐4‐ones in the presence of an amino acid‐derived urea catalyst (TLU) gives rise to desired 5‐dialkylated oxazolones such as (III) and (VI).
ChemInform Abstract: Synthesis of Annulated Anthracenes, Carbazoles, and Thiophenes Involving Bradsher‐Type Cyclodehydration or Cyclization—Reductive‐Dehydration Reactions.
Authors: Rafiq Settu Muhamad , Sivasakthikumaran Ramakrishnan , Karunakaran Jayachandran , Mohanakrishnan Arasambattu K.
Published: December 2015

A conventional BF3·OEt2‐mediated Bradsher‐type cyclodehydration of 2‐arylmethyl benzaldehydes affords polycyclic aromatic and heteroaromatic compounds.
ChemInform Abstract: [2 + 2] Cycloadditions of Electron‐Poor Acetylenes to Endocyclic Enaminones: Ring‐Expansion Reactions.
Authors: Bezensek Jure , Prek Benjamin , Groselj Uros , Pockaj Marta , Svete Jurij , Stanovnik Branko
Published: December 2015

This reaction affords the corresponding ring‐expansion and michael addition products.
ChemInform Abstract: Ruthenium(II) Carbonyl Complexes Designed with Arsine and PNO/PNS Ligands as Catalysts for N‐Alkylation of Amines via Hydrogen Autotransfer Process.
Authors: Ramachandran Rangasamy , Prakash Govindan , Nirmala Muthukumaran , Viswanathamurthi Periasamy , Malecki Jan Grzegorz
Published: December 2015

A series of Ru(II) carbonyl complexes bearing phosphine‐functionalized hydrazone/thiosemicarbazone as well as triphenylarsine ligands are synthesized and applied as catalysts in N‐alkylation reactions of amines, diamines and sulfonamides with benzyl alcohols.
ChemInform Abstract: DDQ‐Mediated Direct C(sp3)—H Cyanation of Benzyl Ethers and 1,3‐Diarylpropenes under Solvent‐ and Metal‐Free Conditions.
Authors: Kong Shanshan , Zhang Lingqiong , Dai Xiaoli , Tao Lianzhi , Xie Chunsong , Shi Lei , Wang Min
Published: December 2015

A direct cyanation of benzyl ethers and 1,3‐diarylpropenes with Me3SiCN is performed under solvent‐ and metal‐free conditions.
ChemInform Abstract: The Selective Cross‐Coupling of Secondary Alkyl Zinc Reagents to Five‐Membered‐Ring Heterocycles Using Pd‐PEPPSI‐IHeptCl.
Authors: Atwater Bruce , Chandrasoma Nalin , Mitchell David , Rodriguez Michael J. , Pompeo Matthew , Froese Robert D. J. , Organ Michael G.
Published: December 2015

The title catalyst allows a selective alkylation at C‐2 or C‐3 of the heteroaromatic ring and thus renders possible an approach to complex new compounds required in medicinal and material science.
ChemInform Abstract: Nucleophilic Conjugate 1,5‐Addition of Gilman Reagents to (E)‐Hex‐2‐en‐4‐ynedioates: An Access to β(γ′)‐Substituted Muconates.
Authors: Tai Hung‐Che , Chavan Arjun S. , Chuang Shih‐Ching
Published: December 2015

This unusual nucleophilic addition reaction proceeds with excellent chemo‐ and regioselectivity.
ChemInform Abstract: Visible Light‐Induced Selective Hydrobromodifluoromethylation of Alkenes with Dibromodifluoromethane.
Authors: Lin Qing‐Yu , Xu Xiu‐Hua , Qing Feng‐Ling
Published: December 2015

Eosin Y is an efficient photocatalyst for the hydrobromodifluoromethylation of alkenes.
ChemInform Abstract: Aerobic Oxidative C—H/C—H Coupling of Azaaromatics with Indoles and Pyrroles in the Presence of TiO2 as a Photocatalyst.
Authors: Utepova I. A. , Trestsova M. A. , Chupakhin O. N. , Charushin V. N. , Rempel A. A.
Published: December 2015

Mono‐, di‐, and triazines are highly selective coupled with indoles or pyrroles using air oxygen/TiO2 as an effective photocatalytic oxidative system.
ChemInform Abstract: Tertiary Amine Promoted Asymmetric Aldol Reaction of Aldehydes.
Authors: Gut Bartosz , Mlynarski Jacek
Published: December 2015

The first direct enantioselective organocatalytic self‐aldol reaction of α‐oxyaldehydes is developed.
ChemInform Abstract: Carboxylate‐Assisted Ruthenium(II)‐Catalyzed C—H Activations of Monodentate Amides with Conjugated Alkenes.
Authors: Li Jie , Ackermann Lutz
Published: December 2015

This method enables chemoselective hydroarylation of unsaturated ketones with benzamides.
ChemInform Abstract: Chiral N‐(tert‐Butyl)‐N‐methylaniline Type Ligands: Synthesis and Application to Palladium‐Catalyzed Asymmetric Allylic Alkylation.
Authors: Mino Takashi , Asakawa Minato , Shima Yamato , Yamada Haruka , Yagishita Fumitoshi , Sakamoto Masami
Published: December 2015

The allylic alkylation of malonates with allylic esters is performed in high yields and with very high enantiomeric excess.
ChemInform Abstract: Rhodium‐Catalyzed Tandem Addition—Cyclization of Alkynylimines.
Authors: Choi Kyoungmin , Joo Jung Min , Lee Chulbom
Published: December 2015

Alkyne‐tethered N‐sulfinyl and N‐sulfonylimines react with organoboron and organozinc reagents via 1,2‐addition to the alkyne and exo‐selective cyclization, thus offering access to complex alkylidene‐substituted cyclobutyl and cyclopentyl amines.
ChemInform Abstract: Diastereoselective Synthesis of Polysubstituted Cyclopentanols and Cyclopentenes Containing Stereogenic Centers via Domino Michael/Cyclization Reaction.
Authors: Ahadi S. , Naghdiani Z. , Balalaie S. , Rominger F.
Published: December 2015

The reaction between malononitrile (II), β‐nitrostyrenes (III), (VI), and (IX), and phenacyl (I) as well as p‐bromophenacyl (V) bromides gives the corresponding cyclopentanones (IV) and (VII), while p‐methoxyphenacyl bromide (VIII) gives cyclopentenes (X).
ChemInform Abstract: Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4]nonane‐1,6‐diones.
Authors: Yang Bin‐Miao , Cai Pei‐Jun , Tu Yong‐Qiang , Yu Zhi‐Xiang , Chen Zhi‐Min , Wang Shuang‐Hu , Wang Shao‐Hua , Zhang Fu‐Min
Published: December 2015

Up to four consecutive stereocenters are successfully constructed in excellent enantioselectivities.
ChemInform Abstract: Oxidative Coupling Between Methylarenes and Ammonia: A Direct Approach to Aromatic Primary Amides.
Authors: Zhao Zhenguang , Wang Tao , Yuan Lin , Hu Xu , Xiong Fei , Zhao Junfeng
Published: December 2015

A FeCl3‐catalyzed direct oxidative amidation between methylarenes and aqueous NH3 using a TBHP/TBAI oxidation system is presented.
ChemInform Abstract: Ligand‐Controlled para‐Selective C—H Arylation of Monosubstituted Arenes.
Authors: Xu Hui , Shang Ming , Dai Hui‐Xiong , Yu Jin‐Quan
Published: December 2015

The use of N‐heterocyclic components in the required catalytic system is investigated with a series of agents and leads finally to 3‐acetylpyridine or pyridine as the suitable ligand.
ChemInform Abstract: Toward Naphthocyclinones: Doubly Connected Octaketide Dimers with a Bicyclo[3.2.1]octadienone Core by Thiolate‐Mediated Cyclization.
Authors: Ando Yoshio , Hori Subaru , Fukazawa Takumi , Ohmori Ken , Suzuki Keisuke
Published: December 2015

Reaction of bisenone (I) under conditions A) produces the desired skeleton (III) via the active intermediate (II).
ChemInform Abstract: A Copper‐Catalyzed Formal [3 + 2]‐Cycloaddition for the Synthesis of All Different Aryl‐Substituted Furans and Thiophenes.
Authors: Ishikawa Shingo , Noda Yushi , Wada Masaru , Nishikata Takashi
Published: December 2015

Tetraarylfurans are highly efficiently obtained starting with a formal [3+2]‐cycloaddition of various widely available styrenes and bromo keto esters affording diaryl‐substituted dihydrofurans followed by oxidation to give diarylfurans and sequential arylations.
ChemInform Abstract: A Simple and Efficient Access to Naphtho[b]furans by Claisen Rearrangement/Cyclization of Bromonaphthyl 3‐Phenylallyl Ethers.
Authors: Wang Wei , Huang Jin , Zhou Rong , Jiang Zhi‐Jie , Fu Hai‐Yan , Zheng Xue‐Li , Chen Hua , Li Rui‐Xiang
Published: December 2015

A transition‐metal‐free Claisen rearrangement/cyclization reaction is presented for the synthesis of naphthofuran derivatives from bromonaphthyl 3‐arylallyl ethers.
ChemInform Abstract: Regioselective Functionalization of Dibenzothiophenes Through Gold‐Catalyzed Intermolecular Alkyne Oxyarylation.
Authors: Barrett Matthew J. , Davies Paul W. , Grainger Richard S.
Published: December 2015

An efficient procedure is elaborated for the Au‐catalyzed synthesis of 4‐substituted dibenzothiophenes from S‐oxides (I) and alkynes (II).
ChemInform Abstract: Synthesis of 3‐Azabicyclo[3.1.0]hexanes by Insertion of Cyclopropylmagnesium Carbenoids into an Intramolecular C—H Bond Adjacent to a Nitrogen Atom.
Authors: Kimura Tsutomu , Wada Natsumi , Tsuru Takahiro , Sampei Taro , Satoh Tsuyoshi
Published: December 2015

Starting from 1‐chlorocyclopropyl para‐tolylsulfoxides bearing an N,N‐disubstituted aminomethyl group the title reaction is performed with high yield.
ChemInform Abstract: Chemoselective Synthesis of 5‐Alkylamino‐1H‐pyrazole‐4‐carbaldehydes by Cesium‐ and Copper‐Mediated Amination.
Authors: Orrego‐Hernandez Jessica , Cobo Justo , Portilla Jaime
Published: December 2015

Nucleophilic substitution of primary alkylamines with activated pyridyl‐substituted pyrazole derivatives is mediated by the “cesium effect”.
ChemInform Abstract: Two‐Step Synthesis of Blue Luminescent (Pyrrol‐3‐yl)‐1H‐(aza)indazoles Based on a Three‐Component Coupling—Cyclocondensation Sequence.
Authors: Nordmann Jan , Eierhoff Svenja , Denissen Melanie , Mayer Bernhard , Mueller Thomas J. J.
Published: December 2015

Almost all title compounds display an intense blue emission upon excitation in the near UV with enormous Stokes shifts and considerable high fluorescence quantum yields.
ChemInform Abstract: Installation of the Imidazole Ring on Chiral Substrates via Allylic Substitution.
Authors: Kobayashi Yuichi , Kiyotsuka Yohei , Sugihara Yusuke , Wada Kyohei
Published: December 2015

Copper reagents derived from imidazoles (I) undergo highly regioselective and stereoselective substitution reaction with optically active substrates (III).
ChemInform Abstract: Selectfluor—Bu4NI‐Mediated C(sp3)—H Oxidation in Aqueous Media: Synthesis of Δ2‐Isoxazolines from Oximes.
Authors: Shi Di , Qin Hai‐Tao , Zhu Chen , Liu Feng
Published: December 2015

This transition‐metal‐free approach generates Δ2‐isoxazolines from oximes by radical‐mediated C(sp3)—H oxidation.
ChemInform Abstract: Copper‐Catalyzed Cross‐Dehydrogenative‐Coupling (CDC) of Coumarins with Cyclic Ethers and Cycloalkane.
Authors: Wang Chenyang , Mi Xia , Li Qingrui , Li Yabo , Huang Mengmeng , Zhang Jianye , Wu Yusheng , Wu Yangjie
Published: December 2015

4‐Methylcoumarins yield only trace amounts of product due to steric hindrance.
ChemInform Abstract: γ‐Carbon Activation Through N‐Heterocyclic Carbene/Broensted Acids Cooperative Catalysis: A Highly Enantioselective Route to δ‐Lactams.
Authors: Xiao Yonglong , Wang Jinxin , Xia Wenjing , Shu Shuangjie , Jiao Shenchao , Zhou Yu , Liu Hong
Published: December 2015

The desired lactams are available with complete regioselectivity and generally excellent enantioselectivity.
ChemInform Abstract: Synthesis of Heterocycle‐Fused Pyridine N‐Oxides from Oximes and Diazo Compounds via RhIII‐Catalyzed C—H Activation and Annulation.
Authors: Sun Peng , Wu Youzhi , Yang Tie , Wu Xiaoming , Xu Jinyi , Lin Aijun , Yao Hequan
Published: December 2015

A Rh(III)‐catalyzed tandem C—H activation and C—N bond formation reaction between oximes and diazo compounds for the synthesis of heterocycle‐fused pyridine N‐oxides is presented.
ChemInform Abstract: A Straightforward Approach Toward Multifunctionalized Pyridazines via Imination/Electrocyclization.
Authors: Komkov Alexander V. , Komendantova Anna S. , Menchikov Leonid G. , Chernoburova Elena I. , Volkova Yulia A. , Zavarzin Igor V.
Published: December 2015

The chlorovinyl aldehydes are efficiently prepared from ketones by Vilsmeier—Haack reaction.
ChemInform Abstract: Synthesis of 4‐(Dimethylamino)quinazoline via Direct Amination of Quinazolin‐4(3H)‐one Using N,N‐Dimethylformamide as a Nitrogen Source at Room Temperature.
Authors: Chen Xin , Yang Qin , Zhou Yirong , Deng Zhihong , Mao Xuechun , Peng Yiyuan
Published: December 2015

The cost‐effective high‐yielding method tolerates a diverse range of 2‐aryl and 2‐hetaryl substituted quinazolin‐4(3H)‐ones, but no alkyl or unsubstituted analogues.
ChemInform Abstract: Regioselective Synthesis of 2‐Aryl‐4‐(arylethynyl)‐ and 2,4‐Bis(arylethynyl)pyrrolo[2,3‐d]pyrimidines.
Authors: Bucevicius Jonas , Tumkevicius Sigitas
Published: December 2015

The approach is based on a comparative study of Sonogashira and Stille reactions of 2,4‐dichloro‐7‐methylpyrrolo[2,3‐d]pyrimidine with arylalkynes, (arylethynyl)tributylstannanes and aryltributylstannanes, respectively.
ChemInform Abstract: Synthesis of Pyrimidine‐Fused Benzazepines from 5‐Allyl‐4,6‐dichloropyrimidines.
Authors: Acosta‐Quintero Lina M. , Jurado Jorge , Nogueras Manuel , Palma Alirio , Cobo Justo
Published: December 2015

The new title benzazepines are synthesized by base‐promoted aromatic nucleophilic substitution of pyrimidines (I) with different N‐substituted anilines or indoline followed by acid‐promoted intramolecular Friedel—Crafts cyclization.
ChemInform Abstract: Synthesis of a New Tetracyclic Ring System: Pyrrolotriazepinoquinazolinone Derivatives.
Authors: Foeldesi Tamas , Dancso Andras , Simig Gyula , Volk Balazs , Milen Matyas
Published: December 2015

The title compounds are prepared by heating anthranilic acid derivatives (I) with triazepines (II) in glacial acetic acid.
ChemInform Abstract: Intramolecular Palladium‐Catalyzed Alkene Carboalkynylation.
Authors: Nicolai Stefano , Swallow Peter , Waser Jerome
Published: December 2015

Triisopropylsilylethynyl bromide reacts with alkene‐tethered activated carbonyl compounds, thus allowing for the formation of five‐membered carbocycles in high yields and six‐membered carbocycles in moderate yields, albeit with low diastereoselectivities.
ChemInform Abstract: Diastereoselective [4 + 2] Cycloaddition Reaction of 1‐Neomenthyl‐1,2‐diphosphole: Facile Synthesis of P‐Chiral Cage Phosphines.
Authors: Zagidullin Almaz , Miluykov Vasili , Polyancev Fedor , Latypov Shamil , Sinyashin Oleg , Loennecke Peter , Hey‐Hawkins Evamarie
Published: December 2015

1,7‐Diphosphanorbornene (III) is highly diastereoselectively obtained as individual enantiomer by reaction of the title diphosphole with maleic anhydride under mild reaction conditions from cheap and readily available starting materials.
ChemInform Abstract: An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides.
Authors: Cohen Daniel T. , Zhang Chi , Pentelute Bradley L. , Buchwald Stephen L.
Published: December 2015

A new umpolung strategy for the bioconjugation of selenocysteine in unprotected peptides is reported.
ChemInform Abstract: Synthesis of Normorphans Through an Efficient Intramolecular Carbamoylation of Ketones.
Authors: Diaba Faiza , Montiel Juan A. , Serban Georgeta , Bonjoch Josep
Published: December 2015

A novel intramolecular carbamoylation of amidocyclohexanones (I) is developed which proceeds via enamine formation followed by cyclization and concomitant cleavage of the trichloromethyl group.
ChemInform Abstract: Synthesis and Characterization of Discrete FeNi2‐xP Nanocrystals (0 < x < 2): Compositional Effects on Magnetic Properties.
Authors: Hitihami‐Mudiyanselage Asha , Arachchige Maheshika Palihawadana , Seda Takele , Lawes Gavin , Brock Stephanie L.
Published: December 2015

The title nanocrystals are synthesized by injection of Fe(CO)5 into a mixture of Ni(acac)2, trioctylphosphine, octylether, and oleylamine at 230 °C under Ar atmosphere, followed by heating at 350 °C for 10 h.
ChemInform Abstract: Surface Science Approaches for the Preparation of Alumina‐Supported Hydrotreating Catalysts
Authors: Bara Cedric , Devers Elodie , Digne Mathieu , Lamic‐Humblot Anne‐Felicie , Pirngruber Gerhard D. , Carrier Xavier
Published: December 2015

Review: 158 refs.
ChemInform Abstract: Exploration of New Superconductors and Functional Materials, and Fabrication of Superconducting Tapes and Wires of Iron Pnictides
Authors: Hosono Hideo , Tanabe Keiichi , Takayama‐Muromachi Eiji , Kageyama Hiroshi , Yamanaka Shoji , Kumakura Hiroaki , Nohara Minoru , Hiramatsu Hidenori , Fujitsu Satoru
Published: December 2015

Review: [highlights of a research project supported by the Japanese Government; 535 ref]
ChemInform Abstract: Recent Advances in Metal—Organic Frameworks Based on Pyridylbenzoate Ligands: Properties and Applications
Authors: Mehlana Gift , Chitsa Vitalis , Mugadza Tawanda
Published: December 2015

Review: 75 refs.
ChemInform Abstract: Chemistry of the Highly Stable Hindered Cobalt Sandwich Compound (η5‐Cp)Co(η4‐C4Ph4) and Its Derivatives
Authors: Kumar Dheeraj , Deb Mayukh , Singh Jatinder , Singh Nem , Keshav Karunesh , Elias Anil J.
Published: December 2015

Review: synthesis, reactions and applications; 288 refs.
ChemInform Abstract: Ruthenium and Osmium Complexes Containing 2‐(Aminomethyl)pyridine (Ampy)‐Based Ligands in Catalysis
Authors: Chelucci Giorgio , Baldino Salvatore , Baratta Walter
Published: December 2015

Review: 150 refs.
ChemInform Abstract: The Transition‐Metal Chemistry of Amidinatosilylenes, ‐Germylenes and ‐Stannylenes
Authors: Alvarez‐Rodriguez Lucia , Cabeza Javier A. , Garcia‐Alvarez Pablo , Polo Diego
Published: December 2015

Review: 279 refs.
ChemInform Abstract: Fluoride‐Coordination Chemistry in Molecular and Low‐Dimensional Magnetism
Authors: Pedersen Kasper S. , Soerensen Mikkel A. , Bendix Jesper
Published: December 2015

Review: 250 refs.
ChemInform Abstract: Crucial Aspects in the Design of Chirally Modified Noble Metal Catalysts for Asymmetric Hydrogenation of Activated Ketones
Authors: Baiker Alfons
Published: December 2015

Review: 50 refs.
ChemInform Abstract: Transition Metal‐Catalyzed Ketone‐Directed or Mediated C—H Functionalization
Authors: Huang Zhongxing , Lim Hee Nam , Mo Fanyang , Young Michael C. , Dong Guangbin
Published: December 2015

Review: [111 refs.
ChemInform Abstract: Utilization of Methylarenes as Versatile Building Blocks in Organic Synthesis
Authors: Vanjari Rajeshwer , Singh Krishna Nand
Published: December 2015

Review: [latest developments until March 2015 in the utilization of methylarenes adopting C—H functionalization strategies; 169 refs.
ChemInform Abstract: Peptide Self‐Assembly for Nanomaterials: The Old New Kid on the Block
Authors: De Santis Emiliana , Ryadnov Maxim G.
Published: December 2015

Review: 114 refs.
ChemInform Abstract: Advancements in the Conversion of Carbon Dioxide to Cyclic Carbonates Using Metal Organic Frameworks as Catalysts
Authors: Kathalikkattil Amal Cherian , Babu Robin , Tharun Jose , Roshan Roshith , Park Dae‐Won
Published: December 2015

Review: 55 refs.
ChemInform Abstract: Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations
Authors: Kumarasamy Elango , Raghunathan Ramya , Sibi Mukund P. , Sivaguru J.
Published: December 2015

Review: synthesis, characteristics, and applications of nonbiaryl atropisomers in syntetic transformations; 318 refs.
ChemInform Abstract: There′s Something in the Air. Functionalization of C—H Bonds Through Oxidative Coupling under Oxygen Application
Authors: Klussmann M.
Published: December 2015

Review: 16 refs.
ChemInform Abstract: Pharmaceuticals that Contain Polycyclic Hydrocarbon Scaffolds
Authors: Stockdale Tegan P. , Williams Craig M.
Published: December 2015

Review: 376 refs.
ChemInform Abstract: Recent Progress in Designing Shell Cross‐Linked Polymer Capsules for Drug Delivery
Authors: Miksa Beata
Published: December 2015

Review: [163 refs.
ChemInform Abstract: Carbohydrate Nanocarriers in Biomedical Applications: Functionalization and Construction
Authors: Kang Biao , Opatz Till , Landfester Katharina , Wurm Frederik R.
Published: December 2015

Review: 168 refs.
ChemInform Abstract: Metal‐Organic Frameworks for Catalysis
Authors: Bhattacharjee Samiran , Lee Yu‐Ri , Puthiaraj Pillaiyar , Cho Sung‐Min , Ahn Wha‐Seung
Published: December 2015

Review: 91 refs.
ChemInform Abstract: Advancement in Heterogeneous Base Catalyzed Technology: An Efficient Production of Biodiesel Fuels
Authors: Lee H. V. , Juan J. C. , Taufiq‐Yap Y. H. , Kong P. S. , Rahman N. A.
Published: December 2015

Review: 199 refs.
ChemInform Abstract: Application of Preconcentration and Separation Techniques in Atomic Fluorescence Spectrometry
Authors: Deng Dongyan , Zheng Chengbin , Hou Xiandeng , Wu Lan
Published: December 2015

Review: 135 refs.
Do firms with more alliance experience outperform others with less? A three‐level sigmoid model and the moderating effects of diversification
Authors: Tseng Chiung‐Hui , Chen Shih‐Fen S.
Published: December 2015

Whether firms with more alliance experience perform better than those with less and whether the alliance strategy interacts with diversification strategy to shape firm performance are two critical but underexplored questions. To address these queries, this study develops a three‐level sigmoid framework built upon a marginal analysis that contrasts alliance benefits and alliance costs, and considers the moderation of diversification that often closely works with the alliance in shaping firm performance. Empirical results obtained from firms in two alliance‐populated industries support first that the alliance experience‐performance relationship is S‐shaped in that the linkage is negative to alliance novices, positive to alliance experts, and negative again to alliance overusers; and second, that the shape of this sigmoid curve varies systematically between high‐ and low‐diversified firms. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
Authors: Greenough Simon E. , Horbury Michael D. , Smith Nichola A. , Sadler Peter J. , Paterson Martin J. , Stavros Vasilios G.
Published: December 2015

We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two‐photon absorption (TPA) differ from the equivalent complex activated through one‐photon absorption (OPA). We photoactivated a RuII polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620–1000 nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100 ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies.
[Co2(CO)6(Alkynyl)] Complexes of Dibenzosuberyl and Dibenzosuberenyl Carbocations: Dibenzotropylium or Dibenzoheptafulvene?
Authors: Harris Michelle , Brusey Sarah A. , Moore Angela , Ortin Yannick , Müller‐Bunz Helge , Manca Gabriele , Mealli Carlo , McGlinchey Michael J.
Published: December 2015

The reaction of dibenzo[a,d]cycloheptan‐5‐one (dibenzosuberone) and dibenzo[a,d]cyclohept‐10‐en‐5‐one (dibenzosuberenone) with aryl‐ or trimethylsilylacetylides led to the formation of the corresponding alkynyldibenzosuberols and alkynyldibenzosuberenols. Treatment with dicobalt octacarbonyl and then with bis(diphenylphosphino)methane (dppm) furnished the corresponding [Co2(CO)4(dppm)(alkynol)] clusters 25 and 29. Upon protonation with HBF4 at 203 K to generate the relevant cobalt‐stabilised cations, the dibenzosuberyl system 30 exhibited fluxionality such that the cation migrated between cobalt centres. Variable‐temperature 31P NMR spectroscopy revealed a barrier of approximately 12.5 kcal mol−1. In contrast, in the supposedly aromatic [Co2(CO)4(dppm)(dibenzosuberenyl)]+ cation (31), which would be expected to have less need of cobalt stabilisation, the barrier was too high to be measured experimentally, but is certainly in excess of 16 kcal mol−1. These data were rationalised by DFT calculations on the structures and energies of the relevant ground states and transition states, which suggested that the nonplanar alkynyldibenzosuberenyl moiety in 31 is better regarded as a neutral dibenzoheptafulvene coordinated to a cationic alkynyl–dicobalt cluster. The question of the bonding of both aromatic and antiaromatic cations to alkyne–dicobalt clusters is considered, and it is proposed that their stabilities, when complexed, parallel the inversion of (4n+2) π and 4n π systems seen under photochemical conditions.
Amide‐Triazolium‐Appended Anthracenes for Turn‐On Fluorescence Sensing of Anions in Noncompetitive and Competitive Solvents
Authors: Wang Zhi‐Cheng , Wang Zichen , Cao Qian‐Yong , Lin Sen , Wang Zhong‐Wei
Published: December 2015

A new anthracene‐based receptor bearing two arms of amide‐triazolium anion‐binding sites, and its counterpart compound with one amide‐triazolium arm, have been synthesized and characterized. Their ability to bind anions in different solvents (CH3CN, CHCl3 and DMSO) has been investigated in detail by using fluorescence techniques. Both compounds exhibited significant fluorescence turn‐on sensing of F− and H2PO4− ions in noncompetitive and competitive environments with different binding modes. In CH3CN and CHCl3, the receptor with two triazoliums binds H2PO4− in 1:1 and 1:2 host–guest complexes, showing anthracene‐based excimer emission in the 1:1 complex, and strong monomer emission in the 1:2 complex. In DMSO, only the 1:1 stoichiometric complex was detected. In contrast, it binds with F− and AcO− with 1:2 stoichiometry both in noncompetitive and competitive solvents. The anion‐binding mechanism of both compounds was also evaluated by 1H NMR spectrometric titration and density functional theory calculation.