bluuebunny/crossref_metadata_2025 huggingface dataset:
Promoting Flow at Work through Proactive Personality: A Sequential Mediation Model with Evidence from Italian Employees
Authors: Callea Antonino , Caracuzzo Emanuela , Costanzi Marco , Urbini Flavio
Published: February 2022

In recent years, organizations have increasingly become aware of the importance of employee happiness as well as the role of HRM practices and personal resources in promoting well-being at work. Based on the Job Demand–Resources model, we investigated ways in which proactive personality may predict flow at work through sequential mediation via job crafting and work engagement. A total of 362 Italian employees completed an online questionnaire. The results showed a positive correlation between proactive personality, job crafting, and work engagement and flow at work. Additionally, proactive personality had a positive total effect on work engagement and flow at work. However, the significant effect on flow at work disappeared in favor of the sequential indirect effect. These results suggest that proactive employees experience flow at work through the mediating role of job crafting and work engagement. This paper contributes to scientific knowledge by filling a gap in the literature around the mechanisms which underly the relationship between proactivity and flow at work. Furthermore, it provides new evidence and new insights about the role of personal resources in promoting flow in the workplace. Our results here can provide practical implications for organizations.
Important Study on the ∇ Dynamic Hardy–Hilbert-Type Inequalities on Time Scales with Applications
Authors: El-Deeb Ahmed A. , Bazighifan Omar , Cesarano Clemente
Published: February 2022

The main objective of the present article is to prove some new ∇ dynamic inequalities of Hardy–Hilbert-type on time scales. We present and prove very important generalized results with the help of the Fenchel–Legendre transform, submultiplicative functions, and Hölder’s and Jensen’s inequality on time scales. We obtain some well-known time scale inequalities due to Hardy–Hilbert inequalities. For some specific time scales, we further show some relevant inequalities as special cases: integral inequalities and discrete inequalities. Symmetry plays an essential role in determining the correct methods for solutions to dynamic inequalities
Prevalence of the Burden of Diseases Causing Visual Impairment and Blindness in South Africa in the Period 2010–2020: A Systematic Scoping Review and Meta-Analysis
Authors: Xulu-Kasaba Zamadonda Nokuthula , Kalinda Chester
Published: February 2022

The prevalence of visual impairment (VI) continues to rise, despite efforts to reduce it. The burden of disease negatively impacts the quality of life, education opportunities, and other developments in various communities. Henceforth, this study aimed to determine and quantify the major causes of VI in South Africa, to ensure accurate interventions in addressing them and to reduce the burden of ocular disease in that context. A systematic scoping review was conducted to map evidence on VI and ocular diseases, using the PRISMA-P guidelines. English studies were searched for on PubMed, Google Scholar, and EBSCOhost using various search terms. The eligible articles underwent screening and ultimately data extraction to identify major causes of VI in South Africa. A meta-analysis further resulted in pooled prevalence estimates (PPE) using the Inverse Variance Heterogeneity (IVhet) model. Of the 13,527 studies screened at three levels, 10 studies met the inclusion criteria for the final review; however, 9 studies were eligible for quality assessment performed by two independent reviewers. The quality index for the included studies was 71.1%. The prevalence of VI was 2% for blindness and 12% for moderate and severe visual impairment (MSVI). Pooled prevalence identified uncorrected refractive error (URE) (43%), cataract (28%), glaucoma (7%), and diabetic retinopathy (4%) as major causes of MSVI. The leading causes of blindness were untreated cataracts (54%), glaucoma (17%), and diabetic retinopathy (57%). Ocular diseases causing VI are avoidable and similar to those of low-to-middle income countries. MSVI were caused by URE, cataract, glaucoma, and diabetic retinopathy. Blindness was mainly caused by cataracts, glaucoma, and diabetic retinopathy. A strategic plan to manage these conditions would largely reduce the burden of VI in the country. Early screenings and interventions to maximize care at primary health levels would decrease the burden of avoidable blindness in the country significantly.
Adaptive Evolution as a Driving Force of the Emergence and Re-Emergence of Mosquito-Borne Viral Diseases
Authors: Yu Xi , Cheng Gong
Published: February 2022

Emerging and re-emerging mosquito-borne viral diseases impose a significant burden on global public health. The most common mosquito-borne viruses causing recent epidemics include flaviviruses in the family Flaviviridae, including Dengue virus (DENV), Zika virus (ZIKV), Japanese encephalitis virus (JEV) and West Nile virus (WNV) and Togaviridae viruses, such as chikungunya virus (CHIKV). Several factors may have contributed to the recent re-emergence and spread of mosquito-borne viral diseases. Among these important causes are the evolution of mosquito-borne viruses and the genetic mutations that make them more adaptive and virulent, leading to widespread epidemics. RNA viruses tend to acquire genetic diversity due to error-prone RNA-dependent RNA polymerases, thus promoting high mutation rates that support adaptation to environmental changes or host immunity. In this review, we discuss recent findings on the adaptive evolution of mosquito-borne viruses and their impact on viral infectivity, pathogenicity, vector fitness, transmissibility, epidemic potential and disease emergence.
Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus
Authors: Prokhorova Daria , Zhukova (Eschenko) Natalya , Lemza Anna , Sergeeva Mariia , Amirkhanov Rinat , Stepanov Grigory
Published: February 2022

Influenza A virus (IAV) causes a respiratory infection that affects millions of people of different age groups and can lead to acute respiratory distress syndrome. Currently, host genes, receptors, and other cellular components critical for IAV replication are actively studied. One of the most convenient and accessible genome-editing tools to facilitate these studies is the CRISPR/Cas9 system. This tool allows for regulating the expression of both viral and host cell genes to enhance or impair viral entry and replication. This review considers the effect of the genome editing system on specific target genes in cells (human and chicken) in terms of subsequent changes in the influenza virus life cycle and the efficiency of virus particle production.
Viral Aggregation: The Knowns and Unknowns
Authors: Pradhan Swechchha , Varsani Arvind , Leff Chloe , Swanson Carter J. , Hariadi Rizal F.
Published: February 2022

Viral aggregation is a complex and pervasive phenomenon affecting many viral families. An increasing number of studies have indicated that it can modulate critical parameters surrounding viral infections, and yet its role in viral infectivity, pathogenesis, and evolution is just beginning to be appreciated. Aggregation likely promotes viral infection by increasing the cellular multiplicity of infection (MOI), which can help overcome stochastic failures of viral infection and genetic defects and subsequently modulate their fitness, virulence, and host responses. Conversely, aggregation can limit the dispersal of viral particles and hinder the early stages of establishing a successful infection. The cost–benefit of viral aggregation seems to vary not only depending on the viral species and aggregating factors but also on the spatiotemporal context of the viral life cycle. Here, we review the knowns of viral aggregation by focusing on studies with direct observations of viral aggregation and mechanistic studies of the aggregation process. Next, we chart the unknowns and discuss the biological implications of viral aggregation in their infection cycle. We conclude with a perspective on harnessing the therapeutic potential of this phenomenon and highlight several challenging questions that warrant further research for this field to advance.
Crosstalk between Hepatitis B Virus and the 3D Genome Structure
Authors: Dias João Diogo , Sarica Nazim , Cournac Axel , Koszul Romain , Neuveut Christine
Published: February 2022

Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization.
Association of SARS-CoV-2 Vaccinations with SARS-CoV-2 Infections, ICU Admissions and Deaths in Greece
Authors: Malli Foteini , Lampropoulos Ioannis C. , Papagiannis Dimitrios , Papathanasiou Ioanna V. , Daniil Zoe , Gourgoulianis Konstantinos I.
Published: February 2022

The available coronavirus disease 2019 (COVID-19) vaccines have shown their effectiveness in clinical trials. We aimed to assess the real-world effects of SARS-CoV-2 vaccinations in Greece. We combined national data on vaccinations, SARS-CoV-2 cases, COVID-19-related ICU admissions and COVID-19-related deaths. We observed 3,367,673 vaccinations (30.68% of the Greek population), 278,821 SARS-CoV-2 infections and 7401 COVID-19-related deaths. The vaccination rate significantly increased from week 2 to week 6 by 85.70%, and from week 7 to 25 by 15.65%. The weekly mean of SARS-CoV-2 cases, COVID-19 ICU patients and COVID-19 deaths markedly declined as vaccination coverage accumulated. The rate of SARS-CoV-2 cases increased significantly from week 2 to week 13 by 16.15%, while from weeks 14–25 the rate decreased significantly by 13.50%. The rate of COVID-19-related ICU admissions decreased significantly by 7.41% from week 2 to week 4, increased significantly by 17.22% from weeks 5–11, then decreased significantly from weeks 17–20, by 11.99%, and from weeks 21–25, by 16.77%. The rate of COVID-19-related deaths increased significantly from week 2 to week 15 by 12.08% and decreased significantly by 16.58% from weeks 16–25. The data from this nationwide observational study underline the beneficial impact of the national vaccination campaign in Greece, which may offer control of the SARS-CoV-2 pandemic.
The Humoral Immune Response of the ChAdOx1 nCoV-19 Vaccine in Maintenance Dialysis Patients without Prior COVID-19 Infection
Authors: Cheng Chung-Yi , Fang Te-Chao , Liao Hung-Wei , Chen Tso-Hsiao , Chang Jer-Hwa , Lin Yen-Chung , Kao Chih-Chin , Liu Ming-Che , Chang Hui-Wen , Hung Ching-Sheng , Wang Jude Chu-Chun , Hsiao Shih-Hsin , Sue Yuh-Mou
Published: February 2022

Background: Chronic kidney disease (CKD) patients tend to have a reduced immune response to infection and vaccination. The efficacy of current available COVID-19 vaccines in CKD patients has not been widely evaluated. Methods: In the present study, three hundred and eight chronic dialysis patients received ChAdOx1 nCoV-19 (Oxford-AstraZeneca, AZ). Blood tests using an antibody against the receptor-binding domain (RBD) of the S1 subunit of the SARS-CoV-2 spike protein had performed at four designed time points before and after the first and second vaccine. Results: The mean age of patients was 65.5 ± 12.38 years, and the male/female ratio was 61.4%:38.6% (189/119). Two weeks after the first vaccination, only 37.66% of patients had a positive antibody response (>50 AU/mL). However, 65.58% of the participants showed a delayed antibody response ten weeks after the first vaccine. Four weeks after the second vaccine, 94.16% of participants had positive antibody levels. Age was the most significant factor associated with antibody response. Flow cytometry analysis revealed that immune-naïve patients had significantly lower early active B cells and proliferative B cells than the age- and sex-matched immune responders. Conclusion: Despite a delayed response, 94.16% of chronic dialysis patients achieved a positive antibody response after two doses of the AZ vaccine. Age is the most significant factor associated with antibody response.
Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines
Authors: Ravindranath Mepur H. , Ravindranath Narendranath M. , Selvan Senthamil R. , Filippone Edward J. , Amato-Menker Carly J. , El Hilali Fatiha
Published: February 2022

Leukocyte cell-surface HLA-I molecules, involved in antigen presentation of peptides to CD8+ T-cells, consist of a heavy chain (HC) non-covalently linked to β2-microglobulin (β2m) (Face-1). The HC amino acid composition varies across all six isoforms of HLA-I, while that of β2m remains the same. Each HLA-allele differs in one or more amino acid sequences on the HC α1 and α2 helices, while several sequences among the three helices are conserved. HCs without β2m (Face-2) are also observed on human cells activated by malignancy, viral transformation, and cytokine or chemokine-mediated inflammation. In the absence of β2m, the monomeric Face-2 exposes immunogenic cryptic sequences on these cells as confirmed by HLA-I monoclonal antibodies (LA45, L31, TFL-006, and TFL-007). Furthermore, such exposure enables dimerization between two Face-2 molecules by SH-linkage, salt linkage, H-bonding, and van der Waal forces. In HLA-B27, the linkage between two heavy chains with cysteines at position of 67 of the amino acid residues was documented. Similarly, several alleles of HLA-A, B, C, E, F and G express cysteine at 67, 101, and 164, and additionally, HLA-G expresses cysteine at position 42. Thus, the monomeric HC (Face-2) can dimerize with another HC of its own allele, as homodimers (Face-3), or with a different HC-allele, as heterodimers (Face-4). The presence of Face-4 is well documented in HLA-F. The post-translational HLA-variants devoid of β2m may expose several cryptic linear and non-linear conformationally altered sequences to generate novel epitopes. The objective of this review, while unequivocally confirming the post-translational variants of HLA-I, is to highlight the scientific and clinical importance of the four faces of HLA and to prompt further research to elucidate their functions and their interaction with non-HLA molecules during inflammation, infection, malignancy and transplantation. Indeed, these HLA faces may constitute novel targets for passive and active specific immunotherapy and vaccines.
SARS-CoV-2 mRNA Vaccination in People with Multiple Sclerosis Treated with Fingolimod: Protective Humoral Immune Responses May Develop after the Preferred Third Shot
Authors: Achtnichts Lutz , Ovchinnikov Arkady , Jakopp Barbara , Oberle Michael , Nedeltchev Krassen , Fux Christoph Andreas , Sellner Johann , Findling Oliver
Published: February 2022

Evidence suggests limited development of protective IgG responses to mRNA-based vaccines in sphingosine-1-phosphate receptor (S1PR)-modulator treated individuals with multiple sclerosis (MS). We studied the extent of the humoral immune response after the preferred third mRNA SARS-CoV-2 vaccine in S1PR-modulator treated people with MS (pwMS) and insufficient IgG responses after the standard immunization scheme. Eight pwMS that were treated with fingolimod received a third homologous SARS-CoV-2 mRNA vaccine dose, either the Moderna’s mRNA-1273 or Pfizer-BioNTech’s BNT162b2 vaccine. We quantified the serum levels of IgG antibodies against the receptor-binding domain of SARS-CoV-2 four weeks later. An antibody titer of 100 AU/mL or more was considered protective. After the third vaccination, we found clinically relevant IgG titers in four out of eight individuals (50%). We conclude that the humoral immune response may reach protective levels after the third preferred dose of the homologous SARS-CoV-2 mRNA vaccine. Vaccine shots in S1PR-modulator treated pwMS ahead of schedule may be a strategy to overcome insufficient humoral immune responses following the standard vaccination scheme.
Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective
Authors: Haseeb Abid A. , Solyman Omar , Abushanab Mokhtar M. , Abo Obaia Ahmed S. , Elhusseiny Abdelrahman M.
Published: February 2022

Vaccination efforts as a mitigation strategy in the corona virus disease 2019 (COVID-19) pandemic are fully underway. A vital component of understanding the optimal clinical use of these vaccines is a thorough investigation of adverse events following vaccination. To date, some limited reports and reviews have discussed ocular adverse events following COVID-19 vaccination, but a systematic review detailing these reports with manifestations and clinical courses as well as proposed mechanisms has yet to be published. This comprehensive review one-year into vaccination efforts against COVID-19 is meant to furnish sound understanding for ophthalmologists and primary care physicians based on the existing body of clinical data. We discuss manifestations categorized into one of the following: eyelid, orbit, uveitis, retina, vascular, neuro-ophthalmology, ocular motility disorders, and other.
Faecal Proteomics and Functional Analysis of Equine Melanocytic Neoplasm in Grey Horses
Authors: Tesena Parichart , Kingkaw Amornthep , Phaonakrop Narumon , Roytrakul Sittiruk , Limudomporn Paviga , Vongsangnak Wanwipa , Kovitvadhi Attawit
Published: February 2022

Equine melanocytic neoplasm (EMN) is a common disease in older grey horses. The purpose of this study was to examine the potential proteins throughout EMN stages from faecal proteomic outlining using functional analysis. Faecal samples were collected from the rectum of 25 grey horses divided into three groups; normal group without EMN (n = 10), mild EMN (n = 6) and severe EMN (n = 9). Based on the results, 5910 annotated proteins out of 8509 total proteins were assessed from proteomic profiling. We observed differentially expressed proteins (DEPs) between the normal group and the EMN group, and 109 significant proteins were obtained, of which 28 and 81 were involved in metabolic and non-metabolic functions, respectively. We found 10 proteins that play a key role in lipid metabolism, affecting the tumour microenvironment and, consequently, melanoma progression. Interestingly, FOSL1 (FOS like 1, AP-1 transcription factor subunit) was considered as a potential highly expressed protein in a mild EMN group involved in melanocytes cell and related melanoma. Diacylglycerol kinase (DGKB), TGc domain-containing protein (Tgm2), structural maintenance of chromosomes 4 (SMC4) and mastermind-like transcriptional coactivator 2 (MAML2) were related to lipid metabolism, facilitating melanoma development in the severe-EMN group. In conclusion, these potential proteins can be used as candidate biomarkers for the monitoring of early EMN, the development of EMN, further prevention and treatment.
Practitioners’ Perspective on the Prevalent Water Quality Management Practices for Legionella Control in Large Buildings in the United States
Authors: Singh Rajveer , Chauhan Deepika , Fogarty Alanna , Rasheduzzaman Md , Gurian Patrick L.
Published: February 2022

Managing building water systems is complicated by the need to maintain hot water temperatures high enough to control the growth of Legionella spp. while minimizing the risk of scalding. This study assessed water quality management practices in large buildings in the United States. Surveys conducted with building water quality managers found that more than 85% of buildings have hot water temperatures that are consistent with scald risk mitigation guidelines (i.e., <122 °F/50 °C). However, nearly two thirds and three quarters of buildings do not comply with the common temperature guidance for opportunistic pathogen control, i.e., water heater setpoint > 140 °F (60 °C) and recirculation loop > 122 °F (50 °C), respectively; median values for both setpoint and recirculation loop temperatures are 10 °F (6 °C) or more below temperatures recommended for opportunistic pathogen control. These observations suggest that many buildings are prone to Legionella spp. risk. The study also found that 27% of buildings do not comply with guidelines for time to equilibrium hot water temperature, over 33% fail to monitor temperature in the recirculation loop, more than 70% fail to replace or disinfect showerheads, more than 40% lack a written management plan, and only a minority conduct any monitoring of residual disinfectant levels or microbiological quality. Given the rise in Legionellosis infections in recent years, coupled with highlighted water quality concerns because of prolonged water stagnation in plumbing, such as in buildings closed due to COVID-19, current management practices, which appear to be focused on scald risk, may need to be broadened to include greater attention to control of opportunistic pathogens. To accomplish this, there is a need for formal training and resources for facility managers.
Integrated Groundwater Flow Modeling for Managing a Complex Alluvial Aquifer Case of Study Mio-Plio-Quaternary Plain of Kairouan (Central Tunisia)
Authors: Snoussi Manel , Jerbi Hamza , Tarhouni Jamila
Published: February 2022

In central Tunisia, anthropic activities, such as groundwater abstraction for irrigation, have resulted in excessive groundwater level declines of the Mio-Plio-Quaternary aquifer hosted in Kairouan Plain. Besides, the two dams El Houareb and Sidi Saad’s impoundment since the 1980s has deeply modified the natural process of aquifer recharge. Hence, some studies claim the dam’s instauration of this groundwater depletion; however, some other studies attribute this critical situation to an issue of groundwater management. A multidisciplinary study was carried out to retrace the groundwater flow dynamics for 48 years before and after the dams’ erection and to understand the main factors causing the groundwater depletion. Hence, a conceptual model was developed based on gathering all available data from 114 borehole logs, 10 seismic lines, and 08 petroleum wells. Based on this reconstructed geometry, the groundwater head was simulated using the numerical code Modflow. The model was calibrated in steady-state with reference to the piezometric levels measured in 1969 and in the transient state for the period 1970–2017 and validated for the period 2007–2017. The outputs of the calibrated model show a relevant finding of the decrease of the inflows coming from the rivers’ beds (Zeroud and Marguellil) from 1990 to 2017 by 48%; yet, the pumping rate has increased by 119%. The simulated scenario without dams and maintaining the same withdrawals has shown a groundwater level rise downstream of the plain; yet, in its upstream, the depletion was less intense compared to the current model. However, the case of doing without dams and raising withdrawals from the aquifer has generated a huge decline reaching 22 m near Draa Affane.
Automated Customer Complaint Processing for Water Utilities Based on Natural Language Processing—Case Study of a Dutch Water Utility
Authors: Tian Xin , Vertommen Ina , Tsiami Lydia , van Thienen Peter , Paraskevopoulos Sotirios
Published: February 2022

Most water utilities have to handle a substantial number of customer complaints every year. Traditionally, complaints are handled by skilled staff who know how to identify primary issues, classify complaints, find solutions, and communicate with customers. The effort associated with complaint processing is often great, depending on the number of customers served by a water utility. However, the rise of natural language processing (NLP), enabled by deep learning, and especially the use of deep recurrent and convolutional neural networks, has created new opportunities for comprehending and interpreting text complaints. As such, we aim to investigate the value of the use of NLP for processing customer complaints. Through a case study about the Water Utility Groningen in the Netherlands, we demonstrate that NLP can parse language structures and extract intents and sentiments from customer complaints. As a result, this study represents a critical and fundamental step toward fully automating consumer complaint processing for water utilities.
Drip Irrigation Reduced Fertilizer Nitrogen Loss from Lettuce Field—A Case Study Based on 15N Tracing Technique
Authors: Jin Qiu , You Junjian , Xie Meixiang , Qiu Yaliu , Lei Shaohua , Ding Qian , Chen Jingnan
Published: February 2022

Nitrogen losses under different irrigation modes have been evaluated by many studies, yet it is not very clear whether the lost N sources are from the soil or fertilizer. In order to quantitatively investigate the effects of different irrigation modes on fertilizer N loss, we used the 15N-labeledurea (15N abundance of 19.6%) as fertilizer and the lettuce (Lactuca sativa var. angustana iris) as the plant material to conduct a field experiment under three different lower limits of drip irrigation, including 75% (DR1), 65% (DR2) and 55% (DR3), accounting for the field water capacity. A furrow irrigation treatment (FI) with the same irrigation regime as DR2 was used as the control. The fate and balance of 15N under these treatments were studied. The results showed that, after the lettuce harvest, 36.9–48.8% of the applied fertilizer 15N remained in 0–80-cm soil, 32.6–39.4% was absorbed by plants, and 18.6–26.3% was lost via pathways such as volatilization or leaching. Under the same irrigation regime, 15N loss caused by FI (26.3%) was significantly (p < 0.05) higher than that byDR2 (18.9%). Moreover, FI increased the amount of total 15N, mineral 15N and organic 15N in the deeper soil layers (60 cm depth and below), leading to a potential risk of 15N leaching. The soil 15N residue was relatively lower under DR1, while the crop-absorbed 15N or 15N loss was atthe highest level among the three drip irrigation treatments. The correlation analysis results showed that increasing the total irrigation amount or increasing the irrigation frequency might increase the 15N loss. We concluded that using drip irrigation instead of furrow irrigation with controlling the lower irrigation limit at 65% is conducive to improving crop 15N utilization and reducing 15N loss from lettuce fields.
Ortaokul, Lise ve Üniversite Öğrencilerinin Sosyal Medya Tutumlarının Farklı Değişkenler Açısından İncelenmesi
Authors: KALEMKUŞ Fatih , TÜREL Yalın Kılıç
Published: February 2022

Bu araştırma ortaokul, lise ve üniversite öğrencilerinin sosyal medya tutumlarının farklı değişkenler açısından incelenmesi amacı ile yapılmıştır. Tarama modeli kullanılarak gerçekleştirilen araştırmanın örneklemini 92 ortaokul, 100 lise ve 107 üniversite öğrencisi olmak üzere toplam 299 öğrenci oluşturmaktadır. Araştırma verileri Sosyal Medya Tutum ölçeği ve kişisel bilgiler anketi kullanılarak elde edilmiştir. Araştırma sonucunda öğrencilerin cinsiyeti ve mobil telefona sahip olma durumları açısından anlamlı bir farklılığın olmadığı belirlenmiştir. Ancak öğrencilerin öğrenim durumları, sosyal medya kullanma bilgi ve beceri düzeyleri ve sosyal medyada geçirilen sürelere bağlı olarak anlamlı farklılık gösterdikleri belirlenmiştir. Sosyal yetkinlik alt boyutunda erkek öğrenciler lehine, öğrenim durumunda ortaokul öğrencileri lehine, sosyal medya kullanacak bilgi ve beceri düzeyinde ileri düzey lehine ve sosyal medyada fazla vakit geçiren öğrenciler lehine anlamlı farklılık olduğu belirlenmiştir. Paylaşım ihtiyacı ve öğretmenlerle ilişki alt boyutlarında öğrenim durumunda ortaokul öğrencileri lehine, sosyal medya kullanımına yönelik bilgi ve beceri düzeyinde ileri düzey lehine ve sosyal medyada fazla vakit geçiren öğrenciler lehine anlamlı farklılık olduğu belirlenmiştir. Sosyal izolasyon alt boyutunda öğrenim durumunda ortaokul öğrencileri lehine ve sosyal medyada fazla vakit geçiren öğrenciler lehine anlamlı farklılık olduğu belirlenmiştir.
Examining Gifted Primary School Students’ Logical Reasoning Ability
Authors: YILDIZ Ahmet
Published: February 2022

Gifted students have advanced creative, analytical, critical, and logical reasoning skills. Logical reasoning is different from other thinking skills. The logical reasoning skill, which is also a high-level thinking skill and required for other high-level thinking skills, has also been the subject of many studies. However, it has been observed that there are not enough studies on the logical reasoning skills of gifted students. In this study, the logical reasoning levels of gifted primary school students will be analyzed. The research was designed according to the descriptive survey model, one of the quantitative research methods. The sample of the study consists of 38 primary school students in a center where gifted students are educated. The Longeot's Test of Cognitive Development was used as a data collection tool. Frequency and percentage distributions and non-parametric analysis methods were used in the analysis of the data. None of the gifted primary school students got full marks on the test. While none of the gifted primary school students could get full points from the questions belonging to the formal operational period, only 3 students got full points from the questions belonging to the concrete processing period. While the cognitive development level of 26 gifted primary school students is in the formal operational stage, the cognitive development of 12 students is in the concrete operational stage. According to the gender variable of gifted primary school students, there is no statistically significant difference between the mean scores of the concrete and formal operational periods. There is a statistically significant difference in favor of male students in the mean scores of combinatorial analysis problems.
Recommendations for conducting medical and sociological monitoring of the personnel needs of medical organizations on the example of studying the needs of regional pharmaceutical enterprises in pharmacists’ training (part 1)
Authors:   branch of the Private Institution of an Educational Organization of Higher Education Medical University ", Golikova Nataliya Sergeevna ,   Reaviz",   in Moscow, Prisyazhnaya Nadezhda Vladimirovna ,   Institute of Social Sciences, FSAEI HE I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)
Published: February 2022

The paper presents the basics of organizing a comprehensive medical and sociological monitoring study of the needs of pharmaceutical industry organizations in the training of pharmacists and the trends in the development of higher pharmaceutical education in the region under consideration. The acquisition of the above material by the heads and specialists of the teaching staff of educational institutions of higher medical and pharmaceutical education will make it possible to timely identify areas for improving the educational, informational, and career guidance work of an educational organization with specialized faculties. The recommendations are intended for the heads of educational institutions of higher education, the teaching staff of faculties and specialized administering sub-departments, as well as other interested specialists.
The role of vaccination in the prevention of human papillomavirus (HPV)
Authors:   MMU «Reaviz», Moscow, Grozina Elena Olegovna , Gavrilova Alexandra Sergeevna ,   MMU «Reaviz», Moscow, Togonidze Alexander Ramazovich ,   MMU «Reaviz», Devlikamov Rustam Kamilevich ,   MMU «Reaviz», Moscow
Published: February 2022

Human papillomavirus (HPV) is the most common sexually transmitted infection. This virus affects men and women regardless of age, which leads to the development of various diseases. The article reflects the timely prevention of virus infection in order to avoid serious consequences. HPV causes a wide range of reproductive system cancers, including cervical cancer, vulvar and vaginal cancer, and anal cancer and anogenital warts.
Thermophysical characterization of earth blocks stabilized by cement, sawdust and lime
Authors: Azakine Sindanne Sylvere , Ntamack Guy Edgar , Lemanle Sanga Roger Pierre , Moubeke Claude Armand , Kelmamo Sallaboui Eric Sylvain , Bouabid Hamid , Mansouri Khalifa , D’ouazzane Saad Charif
Published: February 2022

Several buildings throughout the world are built with blocks of compressed and stabilized ground. These blocks do not commonly have the same thermal properties necessary for their use. If the incorporation of stabilizer in these blocks like lime or cement increases the mechanical properties, it is not the case for the thermophysical properties. In this paper, the evolution of the thermal properties of earth blocks according to the rates of stabilizer and their nature was discussed. The experimental method of “hot iron” was applied. Results indicate that thermal conductivity increases when percentages of cement and lime increase. However, it decreases when the rates of the sawdust increase. Moreover, thermal resistance decreases according to the percentages of lime and cement, and increases according to the percentages of the sawdust.
Fresh and hardened properties of self-compacting concrete with different mineral additions and fibers
Authors: Haddadou Naima , Chaid Rabah , Ghernouti Youcef , Adjou Naima , Bouzoualegh Malik
Published: February 2022

In this work, several reinforced self-compacting concretes were prepared by using three types of fibers made of steel, polypropylene and glass, and three different types of mineral additions (marble powder, metakaolin and limestone powder). The water to cement ratio was kept constant at 0.34 and fibers were used in combination, keeping the total fiber content constant at 60 kg/m3. Slump flow diameter, L-Box, stability and air content were performed to assess the fresh properties of the concrete. Compressive strength, flexural strength, splitting tensile strength and ultrasonic pulse velocity of the concrete were determined for the hardened properties.Noteworthy performances were generally obtained, particularly in hardened properties for the self-compacting concretes prepared with steel fibers in association with polypropylene fiber and marble powder as mineral addition.
Influence of some industrial wastes as a heavy aggregate on durability of concrete upon utilization in the special constructions
Authors: Gharieb Mahmoud , El-Sayed El-Sayed , Abo-El-Enein Salah , Sakr Khaled , Ali Ali , El-Sokkary T M
Published: February 2022

The aim of this study is to investigate the effect of some industrial wastes as a heavy aggregate on durability of the concrete after exposure to different effects. The coarse aggregates used to perform the concrete were dolomite (control) and lead slag, while fine aggregate were sand and lead slag aggregate. The physical and mechanical properties of use draw aggregates were determined also the physical and mechanical properties of different types of concrete were studied. The linear attenuation coefficients (μ) and half value layer (HVL) of gamma rays measurements have been carried out using γ-rays sources of Cs173 and Co60. Effect of sea water on the mechanical properties of high performance concrete; in addition, corrosion behavior of reinforcing steel embedded in concrete incorporating different aggregates upon exposure to sea water were studied. It was found that, the compressive strength for all concrete mixes made with dolomite and lead slag coarse aggregates satisfy the requirements of compressive strength for high performance concrete (grade-M60) after 28 days of curing in tap water. The results indicate that, the compressive strength values and gamma radiation shielding properties of concrete mix containing lead slag aggregate enhances upon replacing sand by fine portion of lead slag aggregate. The concrete mixes made with lead slag coarse aggregate proved their high endurance and could sustain sea water exposure, achieving compressive strength values exceeding grade M-60 concrete even after 6 months exposure. Lead slag concrete- in spite of its efficient durability-requires the incorporation of a corrosion inhibitor to counteract the hostile effect of the high sulfate concrete in the aggregate.
Effect of glass addition on the properties of cements (CEMI)
Authors: Morsli Hamza , Rabah Chaid , Molez Laurent , Diouri Abdeljebbar
Published: February 2022

The purpose of this study is to recover mineral residues as an additive in cement-based building materials. It is part of a sustainable development approach. The use of recovered and recyclable industrial residues in partial replacement of Portland cement reduces greenhouse gas (GHG) emissions and results in the manufacture of cement with a lower environmental impact.

Using various experimental techniques, particular attention is paid to the behaviour of the glass powder finely crushed and chemically activated associated with Portland cement. This study confirms the improvement in the physicochemical and mechanical properties of cements with the addition of glass powder, which augurs well for its use as a cement additive.
Sustainable Utilization of Plastic Waste in Concrete Mixes - a Review
Authors: Kore Sudarshan D
Published: February 2022

Plastic waste creates serious environmental problems, mainly owing to the inconsistency of the wastes streams. Due to rapid population growth and its consistent necessity the use of plastic is increasing regularly. This creates a large, the quantity of garbage every day which is unhealthy and pollutes the environment. In present scenario solid waste management is a challenge in our country. This paper represents a collection of ideas of various studies done on the use of Plastic Waste Materials in concrete mixes. Conclusions are drawn based upon the respective results of all the mentioned research papers.
ANN modelling approach for predicting SCC properties - Research considering Algerian experience. Part I. Development and analysis of models
Authors: Sahraoui Mohamed , Bouziani Tayeb
Published: February 2022

This paper presents research on the use of artificial neural networks (ANNs) to predict fresh and hardened properties of self compacting concrete (SCC) made with Algerian materials. A multi-layer perceptron network with 5 nodes, 12 inputs, and 5 outputs is trained and optimized using a database of 167 mixtures collected from literature. The inputs for the ANN models are ordinary Portland cement (Cm), polycarboxylate ether superplasticizer (Sp), river sand (RS), crushed sand (CS), dune sand (DS), Gravel 3/8 (G1), Gravel 8/15 (G2), Water (W), Limestone filler (Lim), Marble powder (MP), blast furnace slag (Slag) and natural pozzolan (Pz). Instead, Slump flow (Slump), V-funnel, L-Box, static stability (Pi) and 28 days compressive strength (Rc28) were the outputs of the study. Results indicate that ANN models for data sets collected from literature have a strong potential for predicting 28 days compressive strength. Slump flow, V-funnel time and L-Box ratio could be moderately identified while an acceptable prediction has been obtained for static stability. Results have also confirmed by statistical parameters, Regression plots and residual analysis.
Mechanical characteristics of compressed earth blocks, compressed stabilized earth blocks and stabilized adobe bricks with cement in the town of Ngaoundere - Cameroon
Authors: Goutsaya Janvier , NTAMACK Guy Edgar , Kenmeugne Bienvenu , Charif d’Ouazzane Saâd
Published: February 2022

The aim of this study is to examine the effects of cement stabilization on the mechanical stress of compressed stabilized earth blocks (CSEBs) and adobe stabilized earth bricks (ASEBs). Hence, this work is based on an experimental study carried out in order to determine the geotechnical properties of the samples soil, namely, the dry particle size analysis after washing, the particle size distribution by sedimentometry, Atterberg limits, and the preparation of specimens with different levels of cement  proportions. Moreover, single compression and three-point bending compression out on specimens measuring 4x4x4cm3 and 4x4x16cm3 respectively. The findings indicate that dosing with 8% cement results in a clear increase in compression stress of approximately 25.55% for CSEBs compared to the reference set at 0% and 22.85% for ASEBs. On the other hand, for a dosage of 4%, we observe a slight increase in stress by simple compression of around 3.26% for CSEBs and 3.14% for ASEBs. For three-point bending compression for a cement dosage of 8%, there is also an increase in stress of about 25% for the CSEBs compared to the reference taken at 0% and 23.02% for the ASEBs.
Certain Subclass of Meromorphic β-starlike Functions Associated with a Differential Operator
Authors: Mohammed Zainab Aodeh A.
Published: February 2022

Sharp bounds for the Fekete-Szegö functional |ν_1-ξ〖ν_0〗^2 | are derived for certain class of meromorphic starlike functions ω(z) of order β defined on the punctured open unit disk for which
1-1/t ((D^(n+1˳m) ω(z))/(D^(n˳m) ω(z) )-1)≺χ(z) (t∈C-{0},η≥0,κ>0,n,m∈N_0),
lie in a region starlike with respect to 1 and symmetric with respect to the real axis.
MODEL PELAYANAN PUBLIK TERHADAP REFORMASI BIROKRASI
Authors: Abbas Fitriani , Sadat Anwar
Published: February 2022

Penelitian ini bertujuan untuk mengidentifikasi pelaksanaan reformasi birokrasi, serta menawarkan beberapa solusi untuk perbaikan layanan administrasi perizinan. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus instrumental. Lokasi penelitian dilaksanakan di Dinas Perizinan Kabupaten Buton. Teknik pengumpulan data  yang  digunakan, yaitu:  wawancara mendalam, studi  dokumen  dan  observasi. Hasil penelitian menunjukkan bahwa pelaksanaan reformasi birokrasi dalam pelayanan administrasi perizinan, dari aspek Kelembagaan bahwa pelayanan perizinan Kabupaten Buton sudah berbentuk Pelayanan Terpadu Satu Pintu (One Stop Service); aspek Sumber Daya Manusia bahwa kualifikasi pegawai yang ada tidak sesuai dengan kebutuhan organisasi, kedisiplinan dan tanggungjawab pegawai relatif masih rendah. Reformasi tata kelola daerah dimulai dengan bentuk otonomi daerah. Otonomi daerah mewakili kewenangan untuk mengatur bisnis pemerintahan memiliki karakter lokalitas sesuai dengan inisiatif saja sesuai dengan aspirasi masyarakat. Reformasi tata kelola daerah bertujuan untuk menjadi lebih memaksimalkan layanan fungsi lebih memiliki karakter lokalitas publik. Reformasi pelaksanaan tata kelola daerah dapat dilakukan dengan berhubungan dengan konsepsi mengenai pelayanan publik baru yang berorientasi pada pelayanan masyarakat memiliki karakter responsif terhadap berbagai nilai publik dan kepentingan dan juga non diskriminatif.
Sistem Pemilihan Raja Negeri Munarten Kecamatan Taniwel Kabupaten Seram Bagian Barat
Authors: Touwe Maria A. V. , Tuanaya Wahab , Wance Marno
Published: February 2022

Penelitian ini dilakukan di Negeri Murnaten dengan masalah penelitian yaitu Adat Dan Demokrasi (studi tentang Pemilihan Raja) dengan tujuan penelitian bagaimana penerapan ketentuan adat dalam era demokrasi terkait Pemilihan Raja di Negeri Murnaten, Kecematan Taniwel, Kabupaten Seram Bagian Barat. Hasil penelitian ini menunjukan bahwa (1) sudah ada kesepakaan bersama terhadap pemberlakuan ketentuan adat akan tetapi sekarang sudah terbagi. (2) pada awalnya pemerintah dan masyarakat konsisten dalam menerapkan ketentuan adat dalam pemilihan raja namun, saat ini masyarakat mengalami perubahan pemikiran dalam hal ketentuan adat mengenai pemilihan raja. (3) dukungan masyarakat terhadap ketentuan adat saat ini telah terbagi akibat dari perbedaan pendapat. (4) ketaatan masyarakat terhadap seluruh keputusan adat mengalami perubahan akibat dari kepentingan politik. Oleh karena itu disimpulkan bahwa saat ini antara pemerintah dan masyarakat Negeri Murnaten tidak sejalan dalam menerapkan ketentuan-ketentuan adat terkait proses Pemilihan Raja.
Fungsi Pemerintahan Desa Terhadap Pemerataan Pembangunan di Desa Bola Bulu Kecamatan Pitue Riase Kabupaten Sidenreng Rappang
Authors: Tajuddin Sapri , Ikbal Muhammad , Sulfikar Sulfikar
Published: February 2022

Tujuan dari penelitian ini adalah untuk mengetahui fungsi pemerintah desa terhadap pemerataan pembangunan di Desa Bola Bulu Kecamatan Pitu Riase Kabupaten Sidenreng Rappang. Metode penelitian yang digunakan adalah metode penelitian deskriptif kuantitatif. Populasi penelitian adalah 80 orang yang mendapat pelayanan di Desa Bola Bulu Kecamatan Pitu Riase Kecamatan Sidenreng Rappang dari total populasi sebanyak 2426 orang, penentuan sampel menggunakan purposive sampling, dengan didapat hasil sampel dalam penelitian ini sebanyak 80 orang. Teknik pengumpulan data atau teknik survey yang digunakan yaitu observasi, angket / angket, wawancara, studi pustaka, kemudian data yang diperoleh dikumpulkan dan dianalisis dengan teknik deskriptif kuantitatif dengan menggunakan tabel frekuensi dan persentase. Hasil penelitian menunjukkan bahwa variabel (x) fungsi pemerintahan desa 55,67% kategori cukup baik. Dilihat dari Indikator Transparansi, 37% dikategorikan kurang baik. Selanjutnya variabel (y) Ekuitas Pembangunan yang dihasilkan 67% kategori baik. Dilihat dari Indikator Penjaminan, hubungan dan konsistensi proses pembangunan yang dihasilkan cukup baik sebesar 52%, sedangkan faktor-faktor yang mempengaruhi fungsi Pemerintah Desa dalam Pemerataan Pembangunan di Desa Bola Bulu Kecamatan Pitu Riase Kabupaten Sidenreng Rappang dengan hasil menyatakan bahwa 67% dalam penelitian ini termasuk dalam kategori baik.
Pengaruh Kualitas Pelayanan Kesehatan Terhadap Kepuasan Pasien Puskesmas Kecamatan Panca Rijang Kabupaten Sidenreng Rappang
Authors: Tajuddin Sapri , Hermansyah Sam , Angreani Nurlina
Published: February 2022

Tujuan penelitian ini untuk mengetahui Kualitas Pelayanan Kesehatan Puskesmas Kecamatan Panca Rijang Kabupaten Sidenreng Rappang dan Kepuasan Pasien Puskesmas Kecamatan Panca Rijang Kabupaten Sidenreng Rappang dan Pengaruh Kualitas Pelayanan Kesehatan terhadap Kepuasan Pasien Puskesmas Kecamatan Panca Rijang Kabupaten Sidenreng Rappang.

Populasi dalam penelitian ini adalah keseluruhan pasien rujukan rawat jalan dan kunjungan rawat jalan di Puskesmas Kecamatan Panca Rijang yaitu 2,114 orang. Sampel yang di gunakan peneliti adalah 95,48 dibulatkan 95 responden, diambil berdasarkan teknik insidental sampling. Adengan Tipe penelitian Deskriptif Kuantitatif. Teknik pengumpulan dimana data yang digunakaan adalah hasil observasi, quisioner, wawancara dan studi kepustakaan. Data yang yang terkumpul kemudian digunakan dengan cara teknik analisis data, dengan menggunakan SPSS 16.0 for Windows dan  Skala Likert.

Penelitian ini menunjukkan hasil  bahwa kualitas pelayanan kesehatan Puskesmas Kecamatan Panca Rijang Kabupaten Sidenreng Rappang dengan rekapitulasi 58,12% dikategorikan kurang baik. kepuasan pasien Puskesmas Kecamatan Panca Rijang Kabupaten Sidenreng Rappang dengan rekapitulasi 63,2% dikategorikan baik, meski demikian, diketahui bahwa terdapat masalah pada indikator lokasi 60,4%, fasilitas 57%, imange 60%. Pengaruh kualitas pelayanan kesehatan terhadap kepuasan pasien Puskesmas Kecamatan Panca Rijang Kabupaten Sidenreng Rappang  dengan nilai thitung ≥ ttabel1.740 ≥ 1.661 maka Ho ditolak dan Ha diterima, artinya berpengaruh/signifikan.
PERAN LSM DALAM MELAKUKAN ADVOKASI TERHADAP KEBIJAKAN PEMERINTAH
Authors: Fadillah Muhammad Fiqri , Aidin Aidin
Published: February 2022

This research has focused on the role of a non-governmental organization that advocates against the PAUD policy in management are still many forms found differences in the delivery of educational systems. This research method is qualitative descriptive. The results of this research to find out which social Practices undertook NGOs is a form of Colored Poor relations of duality based on her theory of structural discussed by Giddens.