bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of epidemiological characteristics of extrapulmonary tuberculosis from South-Central China
Authors: Yu Yanyan , Xiang Yu , Liu Haican , Yang Shuliu , Li Machao , Liu Binbin , Xu Da , Wu Yaning , Li Wenbin , Fang Tanwei , Li Jixiang , Xu Donglei , Wan Kanglin , Tan Yunhong , Yuan Xiuqin , Li Guilian
Published: July 2024

Objectives

This study aimed to investigate the epidemiological and drug resistance (DR) characteristics of extrapulmonary tuberculosis (EPTB) in South-Central China.

Methods

EPTB inpatients who were culture-positive for Mycobacterium tuberculosis were retrospectively included in a study at a provincial TB hospital in Hunan, a province in South-Central China, from January 2013 to December 2021. Demographic, clinical, and drug susceptibility data were retrieved from TB treatment records. Descriptive statistical methods and a Chi-squared test were used to analyze the epidemiological and DR characteristics of EPTB patients. A logistic regression model was used to explore the risk factors of rifampicin-resistant/multidrug-resistant (RR/MDR)-EPTB.

Results

A total of 1,324 cases were included. The majority of EPTB patients were in the age range of 20–29 years, were predominantly men (male-to-female ratio: 2.03), and were farmers (65.63%). Most EPTB cases were found in 2013 and 2017 from 2013 to 2021. The most prevalent subtypes of EPTB were lymphatic TB (29.83%, 395/1,324), multiple EPTB (20.85%, 276/1,324), and musculoskeletal TB (14.65%, 194/1,324). Musculoskeletal TB and genitourinary TB predominantly presented as exclusive EPTB forms, while lymphatic TB and pharyngeal/laryngeal TB often co-occurred with pulmonary TB (PTB). Drug susceptibility testing results showed that total DR rates (resistance to any of RFP, isoniazid [INH], streptomycin [STR], and/or ethambutol [EMB]) and RR/MDR rates in EPTB were 25.23% and 12.39%, respectively. Musculoskeletal TB exhibited the highest rates of total DR (31.40%), INH resistance (28.90%), STR resistance (20.10%), EMB resistance (6.20%), MDR (13.90%), and poly-DR (6.70%). The multivariable logistic regression model showed that patients aged from 20 to 59 years (compared to those aged 10 years), workers (compared to retirees), and EPTB patients from the south and west of Hunan (compared to those from the east of Hunan) were at an increased risk of developing RR/MDR EPTB (all OR values > 1).

Conclusion

Our study provided a detailed account of the epidemiological and DR characteristics of EPTB in Hunan province, China. The significant DR rates, particularly in musculoskeletal TB cases, highlight the need for timely diagnosis, effective drug susceptibility testing, and the development of more effective treatment regimens for EPTB, especially targeting musculoskeletal TB treatments.
A review on microfiltration membranes: fabrication, physical morphology, and fouling characterization techniques
Authors: Alsoy Altinkaya Sacide
Published: July 2024

Microfiltration is a commonly used pressure-driven membrane separation process for various applications. Depending on the manufacturing method, either tortuous or capillary pore structures are obtained. The structure plays an important role in controlling flux, selectivity, but most importantly, the fouling tendency of the membrane. This review attempts to cover past and current developments in physical morphology and fouling characterization methods, along with the manufacturing methods for microfiltration membranes. The limitations and advantages of direct microscopic techniques and gas-liquid displacement as an indirect method are discussed for physical characterization. Additionally, the current state of the art and technical challenges for various in-situ and ex-situ fouling characterization techniques are also discussed. Finally, some directions for future research are outlined.
Selecting HyperNav deployment sites for calibrating and validating PACE ocean color observations
Authors: Chamberlain Paul , Frouin Robert J. , Tan Jing , Mazloff Matthew , Barnard Andrew , Boss Emmanuel , Haëntjens Nils , Orrico Cristina
Published: July 2024

A novel ocean profiling float system for calibrating and validating satellite-based ocean color observations has been developed and tested. The float-based radiometric sampling system, herein referred to as HyperNav, is complementary to traditional moored in-situ observing systems and provides additional capability due to the relatively small platform size and high radiometric accuracy that allows for opportunistic deployments at locations during seasons and conditions that are best for ocean color observations. The purpose of this study is to optimize the deployment locations of an array of HyperNav systems to support the Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission by performing System Vicarious Calibration (SVC) observations. Specifically, we present the development of logistical and scientific criteria for selecting suitable sites for developing an SVC network of profiling-float-based radiometric systems capable of calibrating and validating ocean color observations. As part of the analyses described in this paper, we have synthetically deployed HyperNav at potential US-based and international sites, including: north of Crete island; south-east of Bermuda island; south of Puerto Rico island; southwest of Port Hueneme, CA; west of Monterey, CA; west of Kona, HI; and south-west of Tahiti island. The synthetic analyses identified Kona, Puerto Rico, Crete, and Tahiti as promising SVC sites. All sites considered are suitable for generating a significant number of validation match-ups. Optimally deploying HyperNav systems at these sites during the PACE post-launch SVC campaign is expected to cost-effectively provide a large number of SVC match-ups to fulfill the PACE calibration requirements.
The lambs of sheepfoot lane: Oldham Athletic AFC 1960–2023; football, politics and identity
Authors: O'Brien James
Published: July 2024

The article focuses on an overview of the history, politics and cultural identity of Oldham Athletic AFC between 1960 and 2023. During this period the club, a founding member of the Football League, played across six divisions of the game's pyramid. My hometown club, the Latics faced an existential threat to its survival following relegation to the National League in 2022, before being rescued and brought back into local ownership on the long road back to its recapturing its former status. The successes of the Frizzell and Royle eras (1969–1994) contrast with the decline of the club in the 1960s, and its gradual meltdown since the mid—1990s. These are interwoven with the economic, geopolitical and cultural dynamics of the game. The study locates the history of a small club geographically positioned within the vortex of the of the two Manchester giants and Liverpool, in English football's traditional hinterland of the industrial north west. The article has four main themes. Firstly, it examines Oldham Athletic as custodian of local identity, fusing folkloric rituals within the club's historic and contemporary nexus. Secondly, it contextualises the interface between global, glocal and grobal forces impacting on tradition, modernity and post- modernity in the club's lexicon. It then considers the themes of ownership, commodification and globalisation, debating whether Oldham Athletic stands as a bastion of anti- globalisation, or reconfirms existing global patterns at the micro level, incorporating salient theoretical perspectives in this analysis. Finally, the review evaluates whether the political and social class cleavages of the club's roots in Oldham's late Victorian industrial landscape still resonate, or if they have been marginalised by socio- economic changes since 1960.
Gender-based approaches for improving milk safety, value addition, and marketing among smallholder livestock farmers
Authors: Nagasha Judith Irene , Ocaido Michael , Rajala Elisabeth , Abu Hatab Assem , Chiwona-Karltun Linley
Published: July 2024

In the context of Uganda, this study delves into gender-based strategies aimed at enhancing women’s engagement in milk safety, value addition, and marketing within smallholder livestock farming. The objectives were two-fold: first, to document the current practices of women in milk safety, value addition, and marketing channels; second, to examine the constraints, opportunities, and strategies related to the production of safe milk and milk products, along with accessing sustainable markets. Conducted in four sub-counties of the Kiruhura district, this research employed both qualitative participatory methods and structured questionnaires, including 12 focused group discussions and 20 key informant interviews with both women and men. Notably, 217 structured questionnaires were administered. The findings illuminate that women played a central role in milk processing, water provisioning, sanitation, and hygiene practices and were the primary contributors to milk value addition, particularly in the production of butter and ghee. Despite their active involvement, women face challenges in accessing adequate milk quantities, employ traditional labor-intensive procedures, and encounter difficulties in marketing their processed products. Men, often the household heads, held decision-making authority over milk consumption and controlled the selling of milk, contributing to gender disparities. Addressing these challenges necessitates comprehensive support, including training and capacity-building initiatives for both men and women in milk value addition, credit access, and market entry. The study underscores the potential for improved women’s access to milk quantities, particularly for butter and ghee production, to strengthen rural livelihoods and boost dairy production in Uganda.
An international survey on canine urinary incontinence: case frequency, diagnosis, treatment and follow-up
Authors: Falceto M. V. , Caccamo R. , Garrido A. M. , Pisu M. C. , Tejedor M. T. , Trerotoli P. , Nicoli S. , Zagarella P. , Lippi I. , García-Pedraza E. , Rambaldi J. , Kirilova D. , Mitjana O.
Published: July 2024

Introduction

Urinary incontinence (UI) consists of involuntary leakage of urine during the storage phase of urination.

Methods

An anonymous survey was given to Spanish and Italian veterinarians about canine UI treated cases, diagnosis, treatment, follow-up, and professional interest.

Results and discussion

Most veterinarians treated ≤3 cases/quarter, resulting in the percentage of incontinence males being lower than that of females (1-4% vs 0-24%). The percentage of spayed incontinent females was lower in Spain (0-24%) than in Italy (75-100%). Most diagnoses were based on a diagnostic algorithm (Spain: 88.7%; Italy: 65.3%); patient report and history, blood work, urinalysis and abdominal ultrasound. Urethral/bladder pressure measurement was unusual (Spain: 0.2%; Italy: 2.4%). In Spain, radiology with contrast medium and CT urography (26.3% and 34.4%, respectively) were more frequent than in Italy (11.6% and 22.7%, respectively). When suspecting urethral sphincter mechanism incompetence pharmacological trial (Spain: 93.2%; Italy: 78.9%). The first-choice medical treatment was Phenylpropanolamine, followed by Ephedrine and Deslorelin. When pharmacotherapy failed, the most frequent option was drug change, followed by increased drug dosage/frequency of administration, surgical therapy and colposuspension. A review was completed after the first week of treatment followed by periodic reviews. Most of the respondents participated in continuing education only if UI occurred in their everyday practice (Spain: 63.0%; Italy: 55.4%) and about 30% responders did it regardless of the number of UI cases treated (Spain: 30.5%; Italy: 37.4%).

Conclusion

Some recommendations in clinical practice were made. UI can be underestimated by owners; therefore, a complete history should be obtained by veterinarians. Veterinarians should carefully evaluate if spaying is advisable considering it could increase UI risk. A step-by-step approach is recommended and a specific diagnostic-therapeutic algorithm for UI in dogs is provided. Conservative approaches (regular exercise, weight loss in overweight dogs and observing an “incontinence diary” to identify abnormal patterns of urination) are advisable.
Bovine leukemia virus transmission rates in persistent lymphocytotic infected dairy cows
Authors: Benavides Bibiana , Monti Gustavo
Published: July 2024

Bovine leukemia virus (BLV) establishes a lifelong persistent infection in dairy cattle. White blood cell count (WBC) is correlated with proviral load in the blood and milk of BLV-infected cattle, and testing WBC can be used to assess both BLV infectiousness levels and risk of BLV transmission from different types of infected animals. The objective of the study was to compare effective transmission rates (β) and the basic reproduction ratio (Ro) among two types of BLV-infected dairy cows in Chile: those affected with persistent lymphocytosis (PL) vs. aleukemic (AL).The estimated (β) coefficient was higher in PL cattle [1.1; 95% Confidence interval (CI) (−1.6, 3.8)], compared to AL cattle (−3.1; 95% CI = −3.7, −2.5). In addition, the Ro was higher in PL cattle (60.4; 95% CI = 3.5; 820.6), compared to AL cattle (1.5; 95% CI = 0.7, 3.1). The ratio between PL/AL expected rate of cases was 73.9. The estimated effective transmission rate and the Ro were higher in PL cattle compared to AL cattle. The WBC test is a convenient alternative that can be considered for risk identification and risk management of BLV infection in dairy herds; particularly in livestock regions where laboratory capacity is limited (e.g., use of PCR or gene sequencing techniques) and/or molecular tests are not cost-effective. Therefore, when prevalence of infection is high, the removal of PL cattle should be engaged to control BLV within-herds.
Applying the FAO surveillance evaluation tool (SET) to assess the fish farming disease surveillance system in Spain
Authors: Muniesa Ana , Ruiz-Zarzuela Imanol , Lamielle Gael , Von Dobschuetz Sophie , Furones Dolors , Rodgers Chris , Basurco Bernardo
Published: July 2024

EU Member States should ensure that they implement adequate health surveillance schemes in all aquaculture farming areas, as appropriate for the type of production. This study presents the results of applying the FAO’s Surveillance Evaluation Tool (SET) to assess the Spanish disease surveillance system for farmed fish species, which although applied previously in livestock production, is applied here to aquaculture for the first time. Overall, there were important score differences between trout and marine fish (seabass and seabream) surveillance, which were higher for trout in the following areas: Institutional (70.8% versus 50.0%), Laboratory (91.7% versus 47.2%), and Surveillance activities (75.3% versus 61.3%). For other categories, the values were lower and no significant differences were found. However, most surveillance efforts focused only on trout, for which there are EU and WOAH listed (notifiable) diseases. In contrast, for seabream and seabass, for which there are no listed diseases, it was considered that surveillance efforts should, nevertheless, be in place and should focus on the identification of abnormal mortalities and emerging diseases, for which there are as yet no standardized harmonised methodologies.
Can ChatGPT Be a Certified Accountant? Assessing the Responses of ChatGPT for the Professional Access Exam in Portugal
Authors: Albuquerque Fabio , Gomes dos Santos Paula
Published: July 2024

Purpose: From an exploratory perspective, this paper aims to assess how well ChatGPT scores in an accounting proficiency exam in Portugal, as well as its overall understanding of the issues, purpose and context underlying the questions under assessment. Design/methodology/approach: A quasi-experimental method is used in this study. The questions from an exam by the Portuguese Order of Chartered Accountants (OCC, in the Portuguese acronym) served as input queries, while the responses (outputs) from ChatGPT were compared with those from the OCC. Findings: The findings indicate that ChatGPT’s responses were able to deduce the primary issue underlying the matters assessed, although some responses were inaccurate or imprecise. Also, the tool did not have the same score in all matters, being less accurate in those requiring more professional judgment. The findings also show that the ChatGPT did not pass the exam, although it was close to doing so. Originality: To the best of the authors’ knowledge, there is little research on ChatGPT accuracy in accounting proficiency exams, this being the first such study in Portugal. Practical implications: The findings from this research can be useful to accounting professionals to understand how ChatGPT may be used for practitioners, stressing that it could assist them and improve efficiency, but cannot, at least for now, replace the human professional. It also highlights the potential use of ChatGPT as an additional resource in the classroom, encouraging students to engage in critical thinking and facilitating open discussion with the guidance of teachers. Consequently, it can also prove beneficial for academic purposes, aiding in the learning process.
Socio-Economic Determinants of the Value Attributed to Human Capital in the Labour Market from the Employee’s Perspective
Authors: Ferreiro-Seoane Francisco-Jesús , del Campo Villares Manuel Octavio , Abad-Itoiz Nerea , Jardón Ferreiro Eladio
Published: July 2024

The aim of this study is to analyse the variables related to knowledge (Talent Management and Training) as a source of human capital in the companies listed in the ranking of the most attractive organisations within the Spanish labour market, published annually by the journal Actualidad Económica (period 2016–2022). We seek to determine the socio-economic variables impacting this assessment, while also exploring the sustainability of the companies in the ranking. Ten hypotheses are thus examined by descriptive statistics, ANOVA, and multiple linear regression models. The results show a significant relationship between permanence, nationality, professional–scientific–technical sector, size, stock market listing, and both variables representative of knowledge in the ranked companies. Focusing on Talent Management, it is noted that permanence in the ranking (>4 years), Anglo-Saxon nationality, being active in the professional, scientific, and technical sector, and being listed on the stock market all play a part. However, Training differs in that size is a factor that positively influences valuation, whereas the international area is irrelevant. Our findings are a key contribution, as there are no previous applied studies that correlate knowledge in the business environment, the valuation of organisations from the employee’s perspective, and several socio-economic variables.
Architecture Preliminary Design and Trade-Off Optimization of Stratospheric Airship Based on MBSE
Authors: Lyu Weihao , Yang Yanchu , Miao Jinggang , Cao Shenghong , Kong Lingsen
Published: July 2024

System architecture design is crucial for forward design in aerostat system engineering, yet a comprehensive research framework has been lacking. This paper presents a new method for stratospheric airship architecture preliminary design and optimization trade-off, grounded in Model-Based Systems Engineering (MBSE) theory. Firstly, a requirement analysis for a stratospheric airship is conducted using SysML, leading to the analysis and acquisition of the airship’s mission architecture design. Additionally, a multidisciplinary coupling simulation platform is developed with MATLAB, and the architecture preliminary design’s Pareto front is derived using the NSGA-II algorithm. Finally, based on the Pareto optimization set, the TOPSIS algorithm is applied to derive the optimal architecture preliminary design scheme for the airship. The optimization results validate the accuracy of the architecture preliminary design obtained from the requirement analysis, the reliability of the multidisciplinary coupling simulation platform, and the feasibility of the optimization algorithms. This comprehensive study spans the requirement analysis to the optimal architecture scheme, providing theoretical reference and design guidance for the forward design of airship systems engineering.
Risk Factors for Injury in Border Collies Competing in Agility Competitions
Authors: Pechette Markley Arielle , Shoben Abigail B. , Kieves Nina R.
Published: July 2024

Border Collies are the most common breed in agility and their reported injury rate is much higher than that of other breeds. We aimed to identify demographic, training, and competition variables associated with the injury risk for this breed. We hypothesized that higher jump heights and competition at national/international levels would increase the injury risk. Data were collected from an internet-based survey. A logistic regression model was built using backward selection. There were 934 Border Collies in the sample, with 488 reporting an injury. The jump height relative to the shoulder height was associated with injury, with dogs jumping noticeably above or below shoulder height more likely to report a history of injury. Other identified risk factors included the number of weekends spent competing/year, the number of competitions at the national level, the age when starting elbow height jumps and backside jumps, the acquisition of the dog from a breeder, and the age of the handler. Factors associated with prolonged injury (>3-month duration) were the age when starting elbow height jumps and having a veterinary assistant as a handler. Border Collies jumping above shoulder height had an increased risk of injury. However, those jumping below shoulder height were also at a higher risk, which could have been due to reverse causality. Similarly, the observed associations regarding differences based on the number of trial weekends/year may have been impacted by reverse causality as well. The increased risk of injury with elbow height jump training at <10 months of age may indicate that the repetitive impact of jump training prior to skeletal maturity negatively influences musculoskeletal development. These data provide valuable information for further prospective studies.
Comparison of Skull Morphometric Characteristics of Simmental and Holstein Cattle Breeds
Authors: Çakar Buket , Tandir Faruk , Güzel Barış Can , Bakıcı Caner , Ünal Burak , Duro Sokol , Szara Tomaz , Spataru Constantin , Spataru Mihaela-Claudia , Gündemir Ozan
Published: July 2024

This study aimed to reveal the morphological characteristics of pure Holstein and Simmental skulls and to obtain reference values for morphometric analysis. Moreover, 54 skulls from 12- to 14-month-old male Holstein (n = 25) and Simmental (n = 29) cattle were collected from Turkey’s Southeastern Anatolia Region between 2023 and 2024. Linear measurements indicated that Holsteins had longer skulls compared to Simmentals. Holsteins exhibited significantly higher values for the greatest length of nasals and the shortest skull length. The facial breadth was wider in Holsteins and statistically distinctive between the breeds. Holsteins had a more oval orbital bony roof, while Simmentals exhibited a wider orbital structure. The orbital index was higher in Holsteins, distinguishing between the two breeds. It was observed that Simmental cattle had a wider occipital region. This difference is likely due to the larger lateral appearance of the Simmental skull, which has more body weight and provides a larger surface area for muscle attachment. These differences not only aid in breed identification but also offer insights into the functional adaptations of each breed. Future research should explore the genetic and environmental factors contributing to these morphological traits, further enriching our knowledge of cattle morphology and its implications for breeding and conservation efforts.
Conserving Madagascar’s Amphibians and Reptiles Requires Collaboration between Scientists
Authors: Andreone Franco , Crottini Angelica , Rakotoarison Andolalao , Rakotoarimalala Fandresena
Published: July 2024

Madagascar is well known for its exceptional biodiversity and striking endemicity levels, which are accompanied by high rates of deforestation and habitat alteration [...]
Assessment of Non-Phytate Phosphorus Requirements of Chinese Jing Tint 6 Layer Chicks from Hatch to Day 42
Authors: Gong Cheng-Yan , Liu Guang , Shi Hong-Peng , Liu Shuan , Gao Xin-Yi , Zhang Shou-Jun , Liu Hao , Li Rui , Wan Dan
Published: July 2024

We aimed to estimate the non-phytate phosphorus (NPP) requirements of Chinese Jing Tint 6 layer chicks. We randomly allocated 720 birds to five treatments with six cages of 24 birds each, feeding them a corn–soybean diet containing 0.36%, 0.41%, 0.46%, 0.51%, and 0.56% NNP. The results showed that the body weight gain (BWG), tibial length, and apparent total tract digestibility coefficients (ATTDC) of P were affected (p < 0.05) by dietary NPP level. A quadratic broken-line analysis (p < 0.05) of BWG indicated that the optimal NPP for birds aged 1–14 d was 0.411%. Similarly, 0.409% of NPP met tibial growth needs. However, 0.394% of NPP was optimal for P utilization according to the ATTDC criterion. For 15–42 d birds, 0.466% NPP, as estimated by the BWG criterion, was sufficient for optimal growth without decreasing P utilization. Using the factorial method, NPP requirements were calculated as 0.367% and 0.439%, based on the maintenance factors and BWG for 1–14 and 15–42 d birds, respectively, to maintain normal growth. Combining the non-linear model with the factorial method, this study recommends dietary NPP levels of 0.367% and 0.439% for 1–14 and 15–42 d birds, respectively, to optimize P utilization without affecting performance.
Endophthalmitis Caused by Bacillus cereus: Clinical Characteristics, Outcomes and Antibiotic Susceptibility
Authors: Zheng Jiayi , Lin Liping , Liao Jingyu , Zhao Xinlei , Lin Jiaqi , Duan Fang
Published: July 2024

Bacillus cereus endophthalmitis is a severe vision-threatening disease. This study aimed to analyze the clinical characteristics, antibiotic susceptibility, and risk factors for poor final visual acuity (VA) and enucleation or evisceration (ENEV) outcomes of B. cereus endophthalmitis patients. We retrospectively reviewed 52 cases (52 eyes) of culture-proven B. cereus endophthalmitis at Zhongshan Ophthalmic Center from January 2013 to December 2023. The mean age of the patients was 38.1 ± 20.1 years, and males composed the majority (90.4%) of the sample size; laborers (32.7%) and farmers (19.2%) were the primary occupations of the patients. All cases were caused by ocular trauma. Forty-one of 51 eyes (80.4%) had a final VA worse than the ability to count fingers (CFs), and 15 of the 52 total eyes (28.8%) underwent ENEV. Binary logistic forward (LR) regression analysis demonstrated that red eye (odds ratio [OR], 13.13; 95% confidence interval [CI], 1.58–108.80; p = 0.017), eye pain (OR, 22.87; 95% CI, 1.00–522.72; p = 0.050), and corneal edema/ulcer (OR, 13.13; 95% CI, 1.58–108.80; p = 0.017) were significant risk factors for poor VA outcomes. Conjunctival sac purulent discharge (OR, 10.08; 95% CI, 2.11–48.12, p = 0.004) and white blood cell (WBC) count (OR, 1.35; 95% CI, 1.06–1.72, p = 0.016) were significant risk factors for ENEV outcomes. B. cereus showed susceptibility rates of 100.0% to vancomycin and ofloxacin; 98.0% to levofloxacin; 93.3% to ciprofloxacin; 87.5% to imipenem; and 78.9% to tobramycin. The susceptibility to azithromycin and clindamycin was 66.7% and 50.0%, respectively. In contrast, B. cereus was resistant to penicillin (susceptibility at 3.8%), cefuroxime (5.6%), and cefoxitin (37.1%).
Towards a Blockchain Hybrid Platform for Gamification of Healthy Habits: Implementation and Usability Validation
Authors: Lopez-Barreiro Juan , Alvarez-Sabucedo Luis , Garcia-Soidan Jose Luis , Santos-Gago Juan M.
Published: July 2024

(1) Background: In developed countries, public health faces a number of problems, including sedentary lifestyles and poor diets, which collectively contribute to the occurrence of preventable diseases. Noncommunicable diseases represent the leading cause of global mortality. Despite the promotion of healthy living, compliance remains a significant challenge. The integration of gamification into health apps has been demonstrated to facilitate behavioral change. Blockchain technology enhances the effectiveness of gamification by providing data trustability and support for auditable incentives. This feature is possible and easy due to the inherent characteristics of blockchain automating processes through Smart Contracts, rewarding participants and creating leaderboards in a transparent and reliable manner. The use of smart contracts and events enhances the traceability and reliability of decentralized applications, including healthcare. Interoperability in blockchain tools facilitates the deployment of complex environments. The aim of this research is the deployment of a tool for the implementation and testing of a gamification platform based on blockchain technology. (2) Methods: Pre-experimental research was carried out to assess the usability of the decentralized application developed. (3) Results: A decentralized application was developed with the objective of gamifying healthy habits. The application was evaluated using the System Usability Scale, obtaining a score of 80.49, and the Cronbach’s Alpha score, which was found to be 0.75. (4) Conclusions: A prototype of a decentralized application connected with a blockchain network to reward challenge fulfilment was deployed. Despite being in early development, it demonstrated high usability. Employing blockchain technology guarantees transparency and traceability while remaining in compliance with legal requirements like the General Data Protection Regulation.
COAT Project: Intercomparison of Thermometer Radiation Shields in the Arctic
Authors: García Izquierdo Carmen , Hernandez Sonia , Parrondo Marina , Casas Alberto , Viola Angelo , Mazzola Mauro , Merlone Andrea , Roulet Yves-Alain
Published: July 2024

A metrological field intercomparison of thermometer radiation shields in the Arctic was conducted with the aim of obtaining information to increase the worldwide comparability of air temperature measurements. Air temperature measurements are performed by different combinations of thermometers and shields. The response of each system (thermometer + shield) to local meteorological conditions depends on the system itself, limiting the comparability of air temperature measurements. Ten different models of radiation shields were included in the intercomparison, involving two campaigns: (1) the laboratory campaign, where all the instrumentation was calibrated just before and just after the field campaign, and (2) the field campaign that lasted 14 months where 41 thermometers were sampled every 2 min. All the delivered data were subjected to quality control to assure the robustness of the conclusions. A reference shield was defined, and the other shields were compared to the reference one for the conditions where maximum divergences were expected, solar irradiance being the highest impact factor. A maximum divergence value of 1.29 °C was derived for one of the shields and, for all the shields, the difference from the reference one decreases with wind speed. Finally, the uncertainties associated with the shields intercomparison were calculated.
Traffic-Related Air Pollution and Childhood Asthma—Are the Risks Appropriately Mitigated in Australia?
Authors: Walter Clare , Sly Peter D. , Head Brian W. , Keogh Diane , Lansbury Nina
Published: July 2024

Childhood asthma is a major health issue in Australia, and traffic emissions play a causative role. Two urban planning policies that impact children’s exposure to traffic emissions are considered in terms of the potential health risks to children in a Melbourne suburb with high truck volumes and hospital attendances for childhood asthma. Firstly, the health impact assessment component of the state planning approval of a major road project, and secondly, local government placement of childcare centres and schools in relation to freight routes. Three sources of air quality monitoring data were examined: (i) a Victorian EPA reference site; (ii) a site with planning approval for development into a childcare centre; and (iii) five sites within the boundary of the West Gate Tunnel Project, an AUD 10 billion road and tunnel project. The Australian Urban Research Infrastructure Network data was utilised to assess distances of childcare centres and schools from major truck routes. A range of cconcentration–response functions for childhood asthma (0–18 years) from international systematic meta-analyses and a smaller Australian cross-sectional study were applied to comparative elevations in fine particulate matter (PM2.5) and nitrogen dioxide (NO2) concentrations between the EPA reference monitor (used for project risk assessment) and local roadside data. It was found that comparative elevations in NO2 concentrations were associated with the following risk increases: developing asthma 13%, active asthma 12%, and lifetime asthma 9%. Overall, 41% of childcare centres (n = 51) and 36% of schools (n = 22) were ≤150 m to a high-density truck route. Truck emissions likely make a substantial contribution to childhood asthma outcomes in the project area. This study exemplifies how current practices may not be commensurate with guiding policy objectives of harm minimisation and equitable protection.
Environmental Aspects and Recycling of Solid-State Batteries: A Comprehensive Review
Authors: Machín Abniel , Cotto María C. , Díaz Francisco , Duconge José , Morant Carmen , Márquez Francisco
Published: July 2024

Solid-state batteries (SSBs) have emerged as a promising alternative to conventional lithium-ion batteries, with notable advantages in safety, energy density, and longevity, yet the environmental implications of their life cycle, from manufacturing to disposal, remain a critical concern. This review examines the environmental impacts associated with the production, use, and end-of-life management of SSBs, starting with the extraction and processing of raw materials, and highlights significant natural resource consumption, energy use, and emissions. A comparative analysis with traditional battery manufacturing underscores the environmental hazards of novel materials specific to SSBs. The review also assesses the operational environmental impact of SSBs by evaluating their energy efficiency and carbon footprint in comparison to conventional batteries, followed by an exploration of end-of-life challenges, including disposal risks, regulatory frameworks, and the shortcomings of existing waste management practices. A significant focus is placed on recycling and reuse strategies, reviewing current methodologies like mechanical, pyrometallurgical, and hydrometallurgical processes, along with emerging technologies that aim to overcome recycling barriers, while also analyzing the economic and technological challenges of these processes. Additionally, real-world case studies are presented, serving as benchmarks for best practices and highlighting lessons learned in the field. In conclusion, the paper identifies research gaps and future directions for reducing the environmental footprint of SSBs, underscoring the need for interdisciplinary collaboration to advance sustainable SSB technologies and contribute to balancing technological advancements with environmental stewardship, thereby supporting the transition to a more sustainable energy future.
Role of Graphene Oxide and Reduced Graphene Oxide in Electric Double-Layer Capacitors: A Systematic Review
Authors: Tene Talia , Bellucci Stefano , Guevara Marco , Romero Paul , Guapi Alberto , Gahramanli Lala , Straface Salvatore , Caputi Lorenzo S. , Vacacela Gomez Cristian
Published: July 2024

The evolution of electric double-layer capacitors (EDLCs) has significantly benefited from advancements in graphene-based materials, particularly graphene oxide (GO) and reduced graphene oxide (rGO). This systematic review consolidates and analyzes existing research on the roles of GO and rGO in enhancing the performance of EDLCs, focusing on synthesis methods, electrode fabrication, electrolytes, and performance metrics such as capacitance, energy density, and cycling stability. Following the PICOS and PRISMA frameworks, a comprehensive literature search was conducted across Scopus, Web of Science, PubMed, and IEEE Xplore, covering the period from 2010 to 2023. A total of 128 articles were initially identified, with 27 studies meeting the inclusion criteria after rigorous screening and full-text analysis. Key findings reveal that the incorporation of GO and rGO in EDLCs leads to significant improvements in specific capacitance, energy density, and cycling stability. Notable advancements include novel synthesis techniques and composite materials such as nitrogen-doped graphene, graphene/polyaniline hybrids, and various metal oxide–graphene composites, which exhibit superior electrochemical performance. However, challenges such as material scalability, environmental sustainability, and consistency in synthesis methods remain. This review stresses the great potential of GO and rGO in the development of high-performance EDLCs and highlights the need for continued research to address existing challenges and further optimize material properties and fabrication techniques.
Towards a Treatment for Leukodystrophy Using Cell-Based Interception and Precision Medicine
Authors: Coulombe Benoit , Chapleau Alexandra , Macintosh Julia , Durcan Thomas M. , Poitras Christian , Moursli Yena A. , Faubert Denis , Pinard Maxime , Bernard Geneviève
Published: July 2024

Cell-based interception and precision medicine is a novel approach aimed at improving healthcare through the early detection and treatment of diseased cells. Here, we describe our recent progress towards developing cell-based interception and precision medicine to detect, understand, and advance the development of novel therapeutic approaches through a single-cell omics and drug screening platform, as part of a multi-laboratory collaborative effort, for a group of neurodegenerative disorders named leukodystrophies. Our strategy aims at the identification of diseased cells as early as possible to intercept progression of the disease prior to severe clinical impairment and irreversible tissue damage.
Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption
Authors: Nelson Christina A. , Brundage James N. , Williams Benjamin M. , Baldridge Jared K. , Stockard Alyssa L. , Bassett Charlton H. , Burger Brandon J. , Gunter Bridger T. , Payne Andrew J. , Yorgason Jordan T. , Steffensen Scott C. , Bills Kyle B.
Published: July 2024

Exercise has increasingly been recognized as an adjunctive therapy for alcohol-use disorder (AUD), yet our understanding of its underlying neurological mechanisms remains limited. This knowledge gap impedes the development of evidence-based exercise guidelines for AUD treatment. Chronic ethanol (EtOH) exposure has been shown to upregulate and sensitize kappa opioid receptors (KORs) in the nucleus accumbens (NAc), which is innervated by dopamine (DA) neurons in the midbrain ventral tegmental area (VTA), which may contribute to AUD-related behaviors. In this study, we investigated the impact of voluntary exercise in EtOH-dependent mice on EtOH consumption, KOR and delta opioid receptor (DOR) expression in the NAc and VTA, and functional effects on EtOH-induced alterations in DA release in the NAc. Our findings reveal that voluntary exercise reduces EtOH consumption, reduces KOR and enhances DOR expression in the NAc, and modifies EtOH-induced adaptations in DA release, suggesting a competitive interaction between exercise-induced and EtOH-induced alterations in KOR expression. We also found changes to DOR expression in the NAc and VTA with voluntary exercise but no significant changes to DA release. These findings elucidate the complex interplay of AUD-related neurobiological processes, highlighting the potential for exercise as a therapeutic intervention for AUD.
Beta-Barrel Nanopores as Diagnostic Sensors: An Engineering Perspective
Authors: Wiswedel Rani , Bui Anh Thi Ngoc , Kim Jinhyung , Lee Mi-Kyung
Published: July 2024

Biological nanopores are ultrasensitive and highly attractive platforms for disease diagnostics, including the sequencing of viral and microbial genes and the detection of biomarkers and pathogens. To utilize biological nanopores as diagnostic sensors, they have been engineered through various methods resulting in the accurate and highly sensitive detection of biomarkers and disease-related biomolecules. Among diverse biological nanopores, the β-barrel-containing nanopores have advantages in nanopore engineering because of their robust structure, making them well-suited for modifications. In this review, we highlight the engineering approaches for β-barrel-containing nanopores used in single-molecule sensing for applications in early diagnosis and prognosis. In the highlighted studies, β-barrel nanopores can be modified by genetic mutation to change the structure; alter charge distributions; or add enzymes, aptamers, and protein probes to enhance sensitivity and accuracy. Furthermore, this review discusses challenges and future perspectives for advancing nanopore-based diagnostic sensors.
Assessing Autistic Traits, Hikikomori Tendencies, Pathological Videogaming, and Eating Disorders in University Students: Are Pathological Videogaming and Eating Disorders Gender-Specific Manifestations of the Autism Spectrum?
Authors: Carpita Barbara , Nardi Benedetta , Giovannoni Federico , Parri Francesca , Cerofolini Gianluca , Bonelli Chiara , Massimetti Gabriele , Pellecchia Enza , Pini Stefano , Cremone Ivan Mirko , Dell’Osso Liliana
Published: July 2024

In the previous literature, specific attention has been paid to investigate autism spectrum symptoms and traits in university students. In this framework, we aimed to evaluate the presence and correlates of autistic traits, hikikomori tendencies, altered eating behaviors, and pathological videogaming in a sample of Italian university students enrolled in bachelor’s degree courses. A total of 1192 students were recruited via an online survey and assessed with the Hikikomori Questionnaire-25, the Adult Autism Subthreshold Spectrum Questionnaire, the Eating Attitude test-26, and the Assessment of Internet and Computer Game Addiction. Our results highlighted significant differences in the prevalence of autistic traits, social withdrawal tendencies, altered eating habits, and pathological videogame use in university students based on gender, age, parents’ level of instruction, and field of study. A significant effect of the presence of autistic traits and gender on the scores obtained with the other questionnaires was reported. Our results not only support the role of autistic traits as a vulnerability factor for the development of a set of psychopathological conditions but also suggest that gender could modulate this vulnerability, supporting the hypothesis of gender-specific phenotypes in the autism spectrum.
Water Vapour Resistance of Exterior Coatings—Influence on Moisture Conditions in Ventilated Wooden Claddings
Authors: Rossebø Katinka Bjørhovde , Kvande Tore
Published: July 2024

Increasing climate fluctuations and extremes due to climate change are particularly concerning for wooden building envelopes, especially in the Nordic region, which has harsh climatic conditions. The exterior coating’s barrier properties are crucial for maintaining building envelopes’ intended lifespans. Hence, it is unfortunate that the vapor resistance of exterior coatings is not openly accessed for commercial products. This study investigates the influence of the water vapour resistance of exterior coatings on the moisture conditions and mould growth risk of ventilated wooden claddings. The sd-value (vapour diffusion-equivalent air layer thickness) is determined for nine free-standing coatings (alkyds, emulsions, and acrylics); in total, 100 specimens are tested with the wet cup method. Additionally, with WUFI Pro, one-dimensional hygrothermal simulations under Nordic climatic conditions investigate how the coatings’ vapour resistance might influence the moisture dynamics of wood. The mould risk is assessed by the add-on WUFI VTT Model. The determined sd-values for the coatings range from 0.453 to 1.350 m (three layers) and from 0.690 to 2.250 m (six layers), showing a strong correlation with the dry film thickness. The vapour resistance of the coatings does not significantly influence the wood moisture content, but lower resistance may cause slightly faster drying. The importance of surface treatment is confirmed. The mould risk is notably higher in a Stavanger climate on a southwest-facing wall compared to Trondheim on a north-facing wall.
Cyclic Behavior of Partially Prefabricated Steel Shape-Reinforced Concrete Composite Shear Walls: Experiments and Finite Element Analysis
Authors: Yu Yunlong , Xie Qiang , Liu Yaping , Xue Yicong
Published: July 2024

Due to the higher lateral stiffness, load-carrying, and energy dissipation capacities compared with traditional reinforced concrete (R.C.) shear walls, steel shape-reinforced concrete (SRC) shear walls, in which steel profiles are encased in the boundary elements, have been widely applied in high-rise buildings. In order to simplify the on-site construction procedure, this paper proposes a novel partially prefabricated steel shape-reinforced concrete (PPSRC) shear wall using throat connectors. Based on the pseudo-static tests of two large-scale specimens, the effect of construction methods (prefabricated or cast in place) on the cyclic behavior of PPSRC shear walls was investigated by the hysteretic loops, skeleton curves, stiffness degradation, energy dissipation, and deformation decomposition. The test results indicated that PPSRC shear walls could exhibit a comparative cyclic response with the cast-in-place SRC shear walls, and the proposed throat connectors could effectively transfer the stress of the longitudinal reinforcements. Finally, a macro-modeling of PPSRC shear walls based on the multi-layer shell elements in OpenSees 3.3.0 was established and validated by the test results, and the parametric analysis of the axial compression, steel ratio, and concrete strength of prefabricated and cast-in-place parts was then conducted.