bluuebunny/crossref_metadata_2025 huggingface dataset:
Perbedaan Tingkat Usability Heuristics Evaluation pada Learning Management System Berdasarkan Latar Belakang Pengguna
Authors: Ramadhan Farha , Fatwanto Agung
Published: July 2023

Perkembangan teknologi yang cukup pesat banyak memberikan manfaat kepada masyarakat di berbagai bidang. Salah satu bentuk pemanfaatan teknologi tersebut adalah penggunaan Learning Management System (LMS), sebuah perangkat lunak pendukung kegiatan belajar-mengajar secara daring. Agar nyaman digunakan, LMS perlu dirancang dengan mempertimbangkan aspek usability sesuai dengan latar belakang calon penggunanya. Oleh karena itu, penelitian ini bermaksud menyelidiki perbedaan persepsi tingkat usability LMS berdasarkan latar belakang penggunanya, yaitu: gender, angkatan (tahun masuk perguruan tinggi), dan frekuensi penggunaan LMS. Penelitian ini menerapkan metode kuantitatif. Desain penelitian yang digunakan adalah penelitian survey dengan teknik pengumpulan data menggunakan kuesioner. Instrumen yang dipakai adalah Usability Heuristics Evaluation. Pengumpulan data dilakukan pada dua perguruan tinggi (PT) negeri di Yogyakarta, masing-masing dilakukan sebanyak dua tahap. Analisis data pada penelitian ini menggunakan analisis statistik deskriptif. Hasil yang didapatkan pada penelitian ini adalah secara umum: i) perempuan cenderung memberikan penilaian tingkat usability LMS yang lebih tinggi dibanding laki – laki; ii) mahasiswa angkatan yang lebih muda cenderung memberikan penilaian tingkat usability LMS yang lebih tinggi dibanding seniornya; iii) pengguna yang lebih sering memakai LMS cenderung memberikan penilaian tingkat usability LMS yang lebih tinggi dibanding mereka yang lebih jarang memakai.
Pemanfaatan Metode TOPSIS dalam Merancang Aplikasi Pendukung Keputusan untuk Memberikan Rekomendasi Hasil Medical Check Up pada Rumah Sakit
Authors: Akbar Ricky , Arifnur Adi Arga , Rahmadoni Jefril , Putri Salsabila Julia
Published: July 2023

Selama ini proses untuk mengetahui hasil keputusan dari pemeriksaan Medical Check Up (MCU) dilakukan secara manual yaitu berdasarkan catatan hasil dari pemeriksaan masing-masing layanan MCU yang ada, kemudian datanya direkap dan diolah melalui aplikasi rumah sakit, sehingga baru didapatkan hasil pemeriksaannya secara keseluruhan, kemudian dokter memberikan rekomendasi terhadap hasil tersebut kepada pasien. Hal ini tentunya membuat hasil dari MCU ini akan menjadi lambat dan kurang akurat, apalagi banyaknya pasien yang akan melakukan pemeriksaan MCU ini tentunya akan menjadikan proses perekapan hasil menjadi lama. Maka salah satu solusi yang dapat diberikan untuk mengatasi permasalahan ini adalah dengan membangun sebuah aplikasi yang dapat secara otomatis memberikan rekomendasi dari hasil rekapan pemeriksaan MCU. Penelitian ini bertujuan untuk membangun aplikasi Sistem Pendukung Keputusan (SPK) dengan memanfaatkan metode Technique For Others Preferences by Similarity to Ideal Solution (TOPSIS). Metode TOPSIS dipilih untuk pembangunan Aplikasi SPK, karena model ini dapat menguraikan berbagai permasalahan yang kompleks menjadi suatu tingkatan dengan banyak faktor atau banyak kriteria, melalui konsep bahwa pilihan alternatif atau yang digunakan adalah yang terbaik. Selain itu, juga sangat memungkinkan apabila diterapkan pada permasalahan dengan banyak kriteria dan alternatif. Untuk mendukung riset ini digunakan metode pengumpulan data dalam bentuk observasi, wawancara, dokumen analisis, dan studi literatur. Luaran yang dihasilkan pada riset ini berupa model SPK yang sudah disesuaikan dengan standar nilai pemeriksaan MCU yang nantinya dijadikan sebagai acuan dalam membuat aplikasi SPK sehingga diharapkan dapat memberikan kemudahan dan mempercepat proses rekomendasi hasil MCU pada rumah sakit.
Rapid Application Development untuk Pengembangan Sistem Informasi Pengelolaan Barang Milik Negara (Studi Kasus UPT PPD Wilayah Sintang)
Authors: Gunawan Emilia Ramadhanty , Ripanti Eva Faja , Novriando Haried
Published: July 2023

Barang Milik Negara (BMN) adalah semua barang yang dibeli atau diperoleh atas beban Anggaran Pendapatan dan Belanja Negara. Untuk itu diperlukan sistem penatausahaan yang baik guna mengoptimalkan pengadaan dan penggunaan barang tersebut. Saat ini UPT-PPD-Sintang masih menghadapi masalah dalam mengelola BMN, yaitu proses distribusi barang ke kantor pelayanan maupun dalam proses penggunaan barang. Tidak adanya sistem dan pelaporan yang terstruktur menyebabkan data laporan yang dibuat oleh staff cenderung tidak akurat sehingga terjadi selisih jumlah barang. Penelitian ini bertujuan untuk mengembangkan sistem yang dapat membantu kegiatan pengelolaan BMN di UPT-PPD-Sintang. Di mana dalam proses pengelolaan barang tersebut meliputi beberapa kegiatan, yaitu: perencanaan, pengadaan, penggunaan, pemindahtanganan, penatausahaan, pengawasan, dan pengendalian. Penelitian dilakukan dengan konsep system development life cycle dan pengembangan sistem dilakukan dengan metode Rapid Application Development (RAD) dengan model prototype. Data yang dibutuhkan dalam pengembangan sistem dikumpulkan dengan beberapa teknik, yaitu studi literatur dan wawancara, di mana hasil pengumpulan data dijadikan input untuk membuat rancangan sistem informasi pengelolaan BMN. Hasil rancangan diimplementasikan menjadi sebuah sistem yang fungsional. Sistem kemudian diuji dengan dua tahap, yaitu: tahap alpha (black box) dan tahap beta (User Acceptance Test (UAT)). Hasil pengujian tersebut menunjukkan bahwa metode RAD dengan model prototype dapat diimplementasikan dengan optimal karena tahapannya yang sangat efektif terutama dalam mengembangkan sistem dengan tim yang kecil serta waktu dan budget yang terbatas. Hal ini menunjukkan bahwa penelitian secara keseluruhan telah berhasil diimplementasikan dan pengembangan awal dari sistem informasi yang dirancang untuk membantu proses pengelolaan barang milik negara di UPT-PPD-Sintang  berhasil dicapai.
Computational Medicinal Chemistry applications to cure Asian-prevalent strain of Hepatitis C Virus
Authors: hussain rashid , Haider Zulkarnain , Khalid Hira , Fatmi M.Qaiser , Carradori Simone , Cataldi Amelia , Zara Susi
Published: July 2023

Hepatitis C Virus (HCV), affecting millions of people worldwide, is the leading cause of the liver disorder, cirrhosis, and hepatocellular carcinoma. HCV is genetically diverse having eight gen-otypes and several subtypes predominant in different regions of the globe. The HCV NS3/4A protease is a primary therapeutic target for HCV with various FDA-approved antivirals and several clinical developments. However, available protease inhibitors (PIs) have lower potency against HCV genotype 3 (GT3), prevalent in South Asia. In this study, the incumbent computational tools were utilized to understand and explore interactions of the HCV GT3 receptor with the potential inhibitors after the virtual screening of one million compounds retrieved from the ZINC database. The molecular dynamics, pharmacological studies, and experimental studies uncovered the potential PIs as ZINC000224449889, ZINC000224374291, and ZINC000224374456 and derivative of ZINC000224374456 from the ZINC library. The study revealed that these top hit compounds exhibited good binding and better pharmacokinetics properties that might be considered the most promising compound against HCV GT3 protease. Viability test, on primary healthy Human Gingival Fibroblasts (HGFs) and cancerous AGS cell line were also performed to assess their safety profile after administration. In addition, Surface Plasmon Resonance (SPR) was also performed for determination of affinity and kinetics of synthesized compounds with target proteins.
Vendi Sampling For Molecular Simulations: Diversity As A Force For Faster Convergence And Better Exploration
Authors: Pasarkar Amey , Bencomo Gianluca , Olsson Simon , Dieng Adji Bousso
Published: July 2023

Molecular dynamics (MD) is the method of choice for understanding the structure, function, and interactions of molecules. However, MD simulations are limited by the strong metastability of many molecules, which traps them in a single conformation basin for an extended amount of time. Enhanced sampling techniques, such as metadynamics and replica exchange, have been developed to overcome this limitation and accelerate the exploration of complex free energy landscapes. In this paper, we propose Vendi Sampling, a replica-based algorithm for increasing the efficiency and efficacy of the exploration of molecular conformation spaces. In Vendi sampling, replicas are simulated in parallel and coupled via a global statistical measure, the Vendi Score, to enhance diversity. Vendi sampling allows for the recovery of unbiased sampling statistics and dramatically improves sampling efficiency. We demonstrate the effectiveness of Vendi sampling in improving molecular dynamics simulations by showing significant improvements in coverage and mixing between metastable states and convergence of free energy estimates for four common benchmarks, including Alanine Dipeptide and Chignolin.
Maximizing single-pass conversion does not result in practical readiness for CO2 reduction electrolyzers
Authors: da Cunha Shashwati , Resasco Joaquin
Published: July 2023

To integrate electrochemical CO2 reduction into the chemicals industry at scale, the outlet streams from CO2R electrolyzers must be product rich. Single-pass conversion is becoming increasingly common as a performance benchmark for CO2R electrolyzers because it indicates concentrated products and reduced separation energy for many catalytic processes. However, our analysis shows that CO2R reactor configurations that maximize single-pass conversion currently suffer from low product concentration in the outlet stream . This is because they restrict CO2 flow or operate in acidic cathode environments, which promote considerable hydrogen evolution as a side reaction. For any gas products besides syngas, high single-pass conversion does not signify that separation energy losses have been eliminated, or that product streams are suitable feedstocks for downstream processes. We therefore recommend that researchers targeting CO2R scaleup report product concentrations rather than relying on single-pass conversion as an indicator of overall performance. Maximizing product concentration is a more meaningful target than maximizing single-pass conversion.
Simultaneous geraniol and citronellol transesterification using Pseudomonas fluorescens lipase for the production of fragrance, flavour and pharmaceutical esters: a kinetic study
Authors: Wikaputri Alisa , Shivaprasad Parimala
Published: July 2023

Terpene esters are one of the most important and versatile compounds for the flavour, fragrance and pharmaceutical industries and are currently produced commercially using petrochemical-based starting materials and chemical catalysis routes. There is a current need in the industry to develop alternatives to the current production process due to an increased demand for natural products, environmental safety and sustainability. This paper for the first time demonstrates a kinetic study for the simultaneous transesterification of geraniol and citronellol using Pseudomonas Fluorescens lipase to produce geranyl and citronellyl esters. The study initially screened the influence of the molar ratio of alcohol to vinyl acetate for individual alcohol transesterification, revealing that increasing the molar ratio led to higher ester yields. The optimised conditions were determined as follows: a molar ratio of 1:4, temperature of 40 °C, agitation speed of 250 RPM, and an enzyme loading of 10 wt.% of alcohol. After 24 hours, the conversion rates reached 95% and 87% for geraniol and citronellol, respectively. These conditions were then applied to the simultaneous transesterification of citronellol and geraniol, with the best experimental condition being a molar ratio of 1:8. The kinetic study demonstrated that the simultaneous transesterification followed a ternary complex mechanism with vinyl acetate inhibition, which was consistent with the experimental data. A preliminary experiment involving the transesterification of rose oil resulted in a conversion rate of 32% for citronellol and 50% for geraniol after 30 hours of reaction time. Overall, this study showcases the potential of enzyme catalysts to selectively produce terpene esters from heterogeneous terpene alcohol mixtures and can be extended to terpene alcohols present in natural essential oils.
Pengembangan LKPD berbasis Android Untuk Mata Pelajaran Sejarah Kelas XII
Authors: FIKRI ASYRUL
Published: July 2023

LKPD can help prepare students for school exams or daily tests. The focus of development is on history subjects for class XII (twelve) students. The LKPD contains material and practice questions. The method used in this research is a research and development method using a software development approach in this case is android-based software. The development of android-based LKPD for History Subject Class XII uses the ADDIE model, namely Analysis (analysis), Design (design), Development (development), Implementation (implementation), and Evaluation (evaluation). The data analysis technique used in this research is descriptive analysis, namely by calculating the percentage value of the validation results. The results of the research and discussion are; The assessment from material experts regarding android-based LKPD for Class XII History Subjects obtained an average value of all indicators of 4.20. Based on this assessment, the teaching materials are declared Eligible to use; Assessments from media experts regarding android-based LKPD for Class XII History Subjects obtained an average score of 4.5 in the "Very Eligible" category; and the trial was conducted at SMAN 1 Rumbio Jaya in class XII with 30 students. Students' assessment of the Android-based LKPD obtained an average value of all indicators of 4.0. Based on these data, the Android-based LKPD was declared "Eligible" to use.
Gambaran Budaya Generasi Milenial Di Kota Surabaya Ditinjau Dari Enam Dimensi Budaya Hofstede
Authors: Fantazilu Ikhwan Fadlu Fadlu
Published: July 2023

Penelitian ini bertujuan mengetahui bagaimana gambaran budaya pada generasi milenial di Kota Surabaya ditinjau dari enam dimensi budaya Hofstede. Adapun penelitian ini merupakan penelitian kuantitatif yang menggunakan kuesioner VSM 08 untuk mengambil data yang dikehendaki. Sampel penelitian ini berjumlah 100 subjek yang diambil menggunakan teknik accidental sampling. Data yang telah terkumpul kemudian dianalisis menggunakan rumus yang telah diformulasikan oleh Hofstede. Hasil penelitian merincikan bahwa generasi milenial di Kota Surabaya yang di tinjau melalui dimensi budaya Hofstede memiliki: (1) Power Distance Index (PDI) memiliki indeks tinggi dengan hasil 65,5 atau meyakini adanya jarak antara pemegang kekuasaan dan yang dibawahinya. (2) Individualism Index (IDV) menunjukkan angka index yang rendah dengan hasil 13,5, di mana hal ini dapat mengindikasikan kolektivisme kuat. (3) Masculinity Index (MAS) dengan hasil 64 atau generasi milenial di Kota Surabaya cenderung menyukai pola persaingan. (4) Uncertainty Avoidance Index (UAI) memiliki hasil indeks yang tinggi yakni 79 dengan artian bahwa masyarakat milenial tidak suka dengan hal-hal yang tidak pasti. (5) Long Term Orientation Index (LTO) memiliki hasil 72,5 atau senang berorientasi masa depan. (6) Indulgence Index (IVR) dengan hasil 46 atau cenderung tidak suka mengumbar hawa nafsu.
STRATEGI PETUGAS PENYULUH KOPERASI LAPANGAN (PPKL) PROVINSI BANTEN TERHADAP EKSISTENSI DIGITALISASI KOPERASI DIMASA PANDEMI COVID-19
Authors: Kiky Rizki Amalia , Amiludin Amiludin , Aditya Toddy
Published: July 2023

PPKL (Petugas Penyuluh Koperasi Lapangan) adalah ujung tombak gerakan pendampingan koperasi di lapangan dan PPKL adalah sebagai Informator, Enumerator (pendataan koperasi), Motivator, Mentor (Pendamping) koperasi serta Mediator (Penghubung/Jembatan) koperasi dengan stakeholder .Ppkl pun di dalam peranannya berkewajiban untuk membimbing dan membina koperasi yang di dalam masa pandemi ini terdapat berbagai penurunan kinerja nya bahkan anjlok dalam perekonomiannya yang menyebabkan perintah pun mengalami rating yang cukup serius, disinilah peran ppkl menjadi sangat penting sebagai ujung tombak dari pemerintahan itu sendiri guna menegakkan kembali kenormalan perekonomian di masa pandemi ini serta mengedukasikan kepada Koperasi tentang pentingnya strategi digitalisasi sebagai salah satu acuan cara guna mendapatkan pencerahan dan berbagai solusi terhadap permasalahan yang terjadi saat ini . Penelitian ini bersifat deskriptif kualitatif , penelitian ini diproses dengan cara wawancara dan observasi medalam serta survey langsung yang kemudian di analisis lalu mendapatkan kesimpulan , Namun penelitian ini pun secara garis besar belum membawa dampak yang cukup baik bagi Dinas Koperasi provinsi Banten   dikarenakan penelitian ini barulah saja diuji coba oleh 1 orang PPKL saja yaitu PPKL Kota Tangerang Binaan Lintas Provinsi Banten, ini dinilai belum terlalu akurat karena harus melalui proses panjang guna untuk menyetarakan program-program dari dinas koperasi provinsi Banten itu sendiri, akan tetapi penelitian ini bisa dijadikan sebagai contoh awal mula yang baik yang bisa di contoh oleh PPKL lain dan di sesuaikan dengan Program Dinas Koperasi itu sendiri dengan berjalannya waktu guna memperbaiki roda perekonomian koperasi itu sendiri.
Comparison of two nursing theories: Virginia henderson's "need theory" and "peaceful end of life theory"
Authors: Kashif Khan
Published: July 2023

The major features of Virginia Henderson's "Nursing Need Theory" and Shirley M. Moore and Cornelia M. Ruland's middlerange "the Peaceful End of Life Theory" (PEL Theory) are focused in this paper. They are grand nursing theories designed for nursing practice, research, and education. These theories were derived in part from the general system, process, and outcomes theory, which is based on the Donabedian structure model. These ideas are primarily concerned with the treatment of terminally ill or dying patients and how to keep them comfortable and at ease. The four assumptions in this context are health, personhood, environment, and nursing. These theories help deal with critical situations. The "Nursing Need Idea" by Virginia Henderson is an influential theory that has had a lot of influence in the nursing sector. This enormous theory is a big theory of human needs that focuses on empowering patients to be as self-sufficient as possible to obtain the best possible outcome at discharge. Henderson's nursing model elaborates on the nurse's job, emphasizing the need to assist patients in rehabilitation and ensure their basic needs are met. If the patient's ailment is terminal, they will be shifted to life support. Middle-range theories have their importance in nursing research, and they are much more feasible to practice than grand nursing theories. Middle-range theories can describe, explain, or forecast phenomena while also being testable.
Majano de Borde (Deza, Soria). Un nuevo abrigo del Paleolítico superior en el valle del río Henar
Authors: Alejandre Alcalde Vicente
Published: July 2023

Se presenta el reciente descubrimiento de un nuevo yacimiento paleolítico localizado en término municipal de Deza, provincia de Soria, emplazado en la margen izquierda del valle del río Henar, afluente del Jalón. El yacimiento ha proporcionado una importante industria lítica elaborada en sílex, en la que destaca la presencia de raspadores y buriles, cuyas características técnicas permiten encuadrarla en el Paleolítico superior.
Piloting Supplementary Materials Aimed at Developing Students’ Problem-Solving and Self-Regulated Learning Skills
Authors: Hačatrjana Liena , Linde Inga
Published: July 2023

Developing students' transversal skills is an important education goal, and its implementation requires equipping teachers with appropriate supplementary materials and methodological support. The aim of the research was to develop supplementary materials aimed at enhancing students’ problem-solving and self-regulated learning skills, and to pilot the materials in secondary school lessons. Problem-solving and self-regulated learning skills are transversal skills, so the supplementary materials were not subject-specific and were designed to help teachers promote these students' skills in the lessons of any school subjects. The set of materials comprised 10 worksheets with both questions and prompts that could promote the development of students’ problem-solving and self-regulated learning skills. In total 139 teachers applied to pilot materials for a month, and 36 of them provided feedback by completing a questionnaire. Participants represented different schools and school subjects and were teachers of Grades 5–12; the majority of them (80,6%) had more than 21 years of work experience. Overall, participants evaluated the materials as very helpful for developing students' problem-solving and self-regulated learning skills, as the materials paid particular attention to planning, self-monitoring and self-reflection through a detailed focus on each of these processes, stimulated by questions in the materials. However, the teachers also concluded that the students lacked the in-depth metacognitive skills to self-analyze and self-regulate their performance, and teachers provided feedback and valuable suggestions for improving the supplementary materials. The study contributes to the research area and work of practitioners by demonstrating that appropriately designed supplementary materials are a valuable and useful tool to help teachers develop students' problem-solving and self-regulated learning skills.
A Concise and Time-efficient Method for Characterizing the Permittivity of Unknown Materials
Authors: Ahn Junhyuk , Youn Youngno , Hong Wonbin
Published: July 2023

We propose a simplified and time-efficient methodology to characterize the permittivity of unknown materials. Based on the transmission line method, this method enables permittivity extraction using a small number of dielectric materials under test (MUT). It is fully compatible with conventional electromagnetic measurement environments and does not require any modification, since the extraction is conducted simply by replacing the MUT above the coplanar waveguide (CPW). The proposed approach enables a more concise and faster measurement process compared to conventional methods previously reported in the literature. This method is then numerically and experimentally verified through various MUTs that have different permittivities or thicknesses. The results are determined to be valid over a continuous frequency range of 1.0 GHz–30.0 GHz with an average accuracy of over 95.0%.
Empowerment of health cadres in conducting stunting prevention efforts using EMPASI SEHATI educational media
Authors: Muharyani Putri Widita , Maulida Mutia Nadra , Adhisty Karolin , Herliawati Herliawati
Published: July 2023

Stunting is one of the nutritional problems experienced by the world, including Indonesia. Stunting occurs due to multifactorial causes. The incidence of stunting increases during the provision of complementary feeding. Many families practice inappropriate feeding practices, including early complementary feeding. Health cadres, as an extension of healthcare workers who interact directly with the community, are important in having the knowledge and ability to educate the community. The purpose of this community service activity is to empower health cadres to accelerate the reduction of stunting prevalence using the EMPASI SEHATI media. There is an increase in the knowledge of health cadres and the community regarding meeting the nutritional needs of children. The EMPASI SEHATI educational media can be an effective media that can be accommodated by health centers to increase public knowledge in the effort to prevent stunting in Indonesia.
Utilizing appropriate technology dry seasoning mixing and sealing machines to increase productivity of cassava chips business
Authors: Caesaron Dino , Salma Sheila Amalia , Ardani Farell , Nasution Faisal Muhammad , Prasetio Murman Dwi
Published: July 2023

Sukapura Village, located in Bandung Regency, has a Family Welfare Empowerment (PKK) program that includes various activities, such as the production of cassava chips. Currently, there is a high demand for cassava chips that cannot be met. Through analysis conducted by the community service team, it has been determined that the demand for cassava chips exceeds the production capacity. One of the contributing factors is the manual process involved in making cassava chips, which takes a relatively long time. One specific manual process is the mixing of cassava chips with dry seasoning. The cassava chips are placed in a container, and then dry spices are added. The mixing process is carried out by hand, ensuring that the spices are evenly distributed throughout the cassava chips. This manual process typically takes around 10-14 minutes for every 1.5 kg of cassava chips. To address this issue and improve efficiency, the community service team has designed and constructed a machine specifically for mixing dry seasoning. With this machine, the mixing process is significantly more efficient, taking less than 5 minutes to achieve optimal results. As a result, the time efficiency and productivity of the mixing process have greatly increased.
Justification of forecast parameters of horticulture development in Tambov region
Authors: Ibragimov Emil'
Published: July 2023

The article presents the analysis of changes in the efficiency of horticultural development in the Tambov region, using the average per capita consumption of fruit and berry products as a target indicator. This indicator is regarded as one of the important indicators of the standard of living in the region. The study is based on the analysis of statistical information and trends in the development of horticulture in the region. The article presents a forecast of changes in the average per capita consumption of fruit and berry products by the population in the near future. The purpose of the forecast is to assess the possible development of horticulture and the standard of living in the Tambov region. Our analysis and forecast are based on many factors, including the current economic situation, demographic data, changes in consumer preferences, provision of fruit storage facilities, wage levels and other socio-economic factors. We also consider possible strategies and measures to improve the efficiency of horticultural development in the region.
Embryo losses. Atlas
Authors: Tral’ Tat’yana , Tolibova Gulrukhsor , Kogan Igor , Olina Anna
Published: July 2023

Histologic examination of abortive material is the basic approach to identify the etiology of miscarriage. Morphological diagnostics in case of embryo loss makes it possible to draw up the plan to fully prepare the woman for future pregnancy, whether spontaneous or after fertility treatment, increasing the chance of a favorable outcome. This educational book contains the data from various studies of the endometrium and abortive material undertaken at the Ott Research Institute of Obstetrics, Gynecology and Reproductology. Histology illustrations are supplemented with images of immunohistochemical studies and confocal laser scanning microscopy photos, as well as detailed text descriptions. Images can be viewed in the atlas, with QR codes linking to high-resolution electronic photos. This edition highlights the features of endometrial structural changes related to different modes of conception, the details of assessing abortive material, trophoblast chromosomal abnormalities, anembryony, hydatidiform mole, choriocarcinoma, as well as examination of embryo losses of various origins. The atlas is intended for pathologists, obstetrician-gynecologists and heads of women’s health clinics, perinatal centers, gynecological departments of general hospitals, fertility specialists, clinical laboratory diagnostics specialists, fellows and heads of departments of obstetrics and gynecology, pathological anatomy, students of all forms of continuous medical education, graduate students and clinical residents.
Research on the effect of different types of fertilization on the maize (Zea mays L.)
Authors: Ivanova Albena Marinova , Plamenov Dragomir , Naskova Pavlina , Yankova Plamena
Published: July 2023

Maize is the cereal crop with the greatest productive potential and production in the world. A field research experiment was conducted in the field settings of the Department of "Plant Production" at the Technical University of Varna, to evaluate the effect of foliar fertilizers on the productivity and quality of Dekalb maize hybrids. Four fertilizer variants were examined and the following biometric parameters were assessed: grain yield, weight per 1000 grains, length of cob, number of rows in cob, number of grains in cob, number of grains per row, weight of grain in cob and weight of the cob. A biochemical analysis of the maize grain was performed and the content of protein, starch and fat was determined. It was established that the combined pairing of soil and foliar fertilization leads to increased productivity and enhanced biometric parameters under study, with the highest values ​​being obtained in the variant ammonium nitrate (rate of 12 kg/dа) + 250 ml/dа NPK 2.5 SO3 with composition 3.0 N: 1.5 P: 10 K: 2.5 SO3 + 250 ml/da SO3 10% Zn, 3% N (sulfides with zinc and nitrogen). It was also ascertained, through the use of the same combination, that the maize hybrids under examination contain the highest amount of protein. Provided, from the findings of the experiment, is a conclusive evidence, that the combination of sowing soil fertilization with ammonium nitrate (rate of 12 kg/da) and two foliar fertilizers (rate of 250 ml/da) – NPK 2.5 SO3 + SO3, 10% Zn, 3% N improved the productivity and quality of the investigated Dekalb maize hybrids.
Onshore ballast water management systems: National perspectives
Authors: Simeonova Anna , Kralev Petar
Published: July 2023

The present paper focuses on ballast water management systems (BWMS) in line with the Ballast Water Management Convention, aiming to prevent marine pollution from harmful alien species transported through ships’ ballast water. Three approaches of BWMS are considered: Ballast water exchange, Onboard and Onshore systems. Solutions regarding ballast water reception and treatment are proposed, including several options: for ports that are equipped with ballast water reception facilities (BWRFs); for ports not equipped with BWRFs and for companies with onshore facilities (OBWRFs).Thoroughly examined in the paper is the applicability of national onshore BWMS inclusive specifically of the expected users of the OBWRFs; suggested stakeholder groups involved in the process and their responsibilities; step by step procedure; documentation of the procedure related to the main parties - the Shipowner/ captain, Port authority, the company with OBWRFs. It has been found out that OBWRFs are more suitable to be applied on national level, bearing in mind that most of the Bulgarian ports are limited to increase their working area. Further research should be carried out about the possible location of the OBWRFs with regard to the necessary infrastructure, equipment, restricted zones, etc.
Retrofitting measure of an ageing multi-purpose ship exposed to short-sea LNG operation
Authors: Yalamov Dimitar , Georgiev Petar Georgiev , Garbatov Yordan
Published: July 2023

The objective of the present study is to analyse the retrofitting measure needed for an ageing multi-purpose ship exposed to a short sea LNG operation in the Black Sea region. Different technical aspects of the retrofitting related to using LNG as fuel for short-sea shipping, including the required volume of the liquefied natural gas, the appropriate type of tanks and the location of tanks on the ship, changes in the main engine and needed additional equipment, are discussed. The cost-benefit feasibility analysis is performed considering the historical and current price of LNG fuel and different taxes related to the generated CO2, examining the Varna-Poti-Varna and Varna-Istanbul-Varna routes.
ESG investment relationship with financial performance of Russian companies
Authors: Izgarova Anna , Rogova Elena , Bakhareva Olga
Published: July 2023

Despite the increased interest in socially and environmentally responsible investments, there is a lack of consensus about the effects they exert on companies’ financial performance. The paper examines the reaction of Russian companies’ stock prices to the news about ESG investments made by these companies. The theoretical basis is stakeholder theory suggesting that firms can achieve long-term success solely by protecting the interests of all their stakeholders – not only shareholders, but also employees, local communities, and future generations. To implement the research, we use the event study on a sample of 202 news items about ESG investments of 11 Russian companies topping the ESG-rating by RA-Expert agency. Data were collected from news search engine Factiva and Yahoo!Finance. The data sample include news and stock prices over the period of 2019–2022. According to the research findings, news about Russian companies’ investments in environmental projects, solution of social problems and corporate governance issues do not lead to a rise in stock returns for these companies. Thus, Russian investors do not consider ESG projects and practices as an important decision-making criterion that increases the investment attractiveness of companies.
Fortalecimiento Lingüístico Fonológico Perceptivo a niños con TDAH Mediante el Uso de Realidad Aumentada (RA)
Authors: López Díaz Kevin , Mayorga Carrera Tomas Sebastian , Navas Moya Milton Patricio , Garces Guayta Lucas Rogerio
Published: July 2023

En este artículo se presenta un estudio sobre el fortalecimiento lingüístico fonológico perceptivo en niños con Trastorno por Déficit de Atención e Hiperactividad (TDAH) mediante el uso de realidad aumentada (RA), por lo que se busca evaluar la efectividad de la RA en el desarrollo de habilidades lingüísticas y de atención en estos niños. Los resultados indican que la RA puede ser una herramienta efectiva para mejorar la capacidad de los niños con TDAH para procesar información lingüística y mejorar su capacidad de atención. Además, se encontró que la RA es una forma motivadora y atractiva para los niños, lo que contribuye a un aprendizaje más efectivo y duradero. En general, este estudio sugiere que la RA es una herramienta valiosa para el fortalecimiento académico en niños con TDAH.
Paralisia supranuclear progressiva (síndrome de Steele-Richardson- Olszewski) associada a crises generalizadas: relato de caso
Authors: Admin Admin
Published: July 2023

Introdução: A Paralisia Supranuclear Progressiva é uma doença neurodegenerativa que afeta principalmente o tronco cerebral e os núcleos da base. O quadro clínico se caracteriza por oftalmoparesia supranuclear, instabilidade postural e demência. Método: Análise de prontuário e revisão da literatura. Descrição do caso: Homem, 74 anos, iniciou quadroparkinsoniano há cerca de 16 anos, com evolução progressiva; inicialmente apresentou alteração postural, instabilidade da marcha e bradicinesia, que evoluiu com enrijecimento do pescoço, com projeção para trás, além de síndrome demencial evidente. Diagnosticado como Doença de Parkinson, foi instituído tratamento com Levodopa, sem melhora clínica ao longo dos anos. Há cerca de oito meses apresentou episódio de crise convulsiva tônico-clônica generalizada com recorrência subsequente, até instituição de terapia anticonvulsivante. Conclusão: A Paralisia Supranuclear Progressiva é uma doença neurodegenerativa, de evolução inexorável, pouco responsiva aos tratamentos clínicos. Atinge, sobretudo, homens, a partir da quinta década de vida, sendo muitas vezes confundida com a Doença de Parkinson. A apresentação é clássica, com predominância da paralisia ocular supranuclear e pouco responsiva a Levodopaterapia; já os relatos de crises convulsivas ou distúrbios da consciência são raramente relatados nas séries de casos estudadas.
ENCEFALITE HERPÉTICA POR HSV-1 – RELATO DE CASO
Authors: Pires Luis Henrique Zago , Reis Carlos Henrique Melo
Published: July 2023

Apresentamos um relato sobre encefalite herpética em um paciente de 48 anos, previamente hígido, morador de Osvaldo Cruz, interior de São Paulo, cujo único sintoma foi tontura de inicio súbito e limitante para deambulação. Não houve apresentação dos sinais comuns de uma encefalite herpética, como alterações de cognição, febre, cefaleias, convulsões e sinais focais. Com o desfecho, o paciente depois de tratado e alta hospitalar, se recuperou em sua totalidade, não apresentando qualquer sequela limitante.
TUMOR CARCINÓIDE PULMONAR: RELATO DE CASO
Authors: Portelli Magalhães Fernanda Ramos , Manhães José Cláudio da Silva , Palmeira Gama Mayra Drummond
Published: July 2023

Introdução: Os tumores carcinóides são neoplasias neuroendócrinas raras de crescimento lento. A maioria dos casos registrados na literatura é diagnosticada entre a quinta e sexta décadas de vida e se manifesta através de infecções pulmonares recorrentes, tosse, hemoptise ou chiado no peito. Classificam-se em típicos e atípicos e o tratamento ideal é a ressecção cirúrgica.Objetivo: Relatar um caso de Tumor Carcinóide Pulmonar.Método: Revisão de prontuárioRelato de Caso: Paciente, sexo feminino, 46 anos, assintomática, encaminhada ao serviço de Cirurgia Torácica devido a um achado incidental na radiografia de tórax de uma massa localizada em terço médio do pulmão esquerdo. Submetida a lobectomia pulmonar como tratamento cirúrgico, apresentando evolução satisfatória. O diagnóstico de Tumor Carcinóide Típico Pulmonar foi confirmado através da imunohistoquímica.Conclusão: O presente relato enfatizou que o tratamento de escolha para tumores carcinóides típicos pulmonares é a ressecção cirúrgica, apresentando um excelente prognóstico.
Haploinsuficiência genômica decorrente da microdeleção envolvendo 13 genes localizados na região cromossômica 7q11.23 em paciente acometido pela síndrome de Williams-Beuren: relato de caso
Authors: Medina-Acosta Enrique , Da Silva Antonio Francisco Alves , Campos Fernandes Regina Célia de Souza
Published: July 2023

Introdução: A síndrome de Williams-Beuren é um distúrbio do neurodesenvolvimento que impacta múltiplos sistemas. A causa mais frequente da síndrome de Williams-Beuren é a microdeleçãosubmicroscópica (0,2Mb a 2,5Mb) na região 7q11.23 no braço longo do cromossomo 7. A condição genética característica em acometidos é a haploinsuficiência genômica determinada pela hemizigose de genes contíguos. O diagnóstico genético não pode ser realizado por cariotipagem banda G devido ao limite de resolução (>5Mb) da técnica de citogenética clássica. O rearranjo segmental pode ser detectado por meio da técnica de hibridação in situ com sondas específicas de DNA marcadas com fluorocromos (FISH) ou por genotipagem de locos de microssatélites altamente polimórficos e a análise de segregação de alelos em núcleos familiares para verificação de hemizigose na região 7q11.23. Objetivos: Relatar um caso de diagnóstico tardio de síndrome de Williams-Beuren, enfatizando as vantagens de confirmação diagnóstica precisa pela genotipagem de seis locos de microssatélites específicos da região 7q11.23, utilizando a Reação Quantitativa Fluorescente em Cadeia da Polimerase (QF-PCR). Métodos: Relato de caso e genotipagem alélica utilizando a QF-PCR para seis locos de microssatélites localizados na região 7q11.23. Resultados: As alterações fenotípicas levaram à hipótese diagnóstica de síndrome de Williams- Beuren. O genótipo da criança apresentou perda da heterozigose esperada em três locos de microssatélites informativos, que definem um intervalofísico de 0,9 Mb, compreendendo 13 genes contíguos. Os alelos maternos informativos ausentes no perfil genético da criança foram D7SNUDIM3_227, D7SNUDIM6_303, D7SNUDIM11_242. A perda da heterozigose é clara evidência da microdeleção, característica em pacientes com síndrome de Williams-Beuren. Conclusões: Análise de segregação dos alelos parentais para o filho revelou a presença de rearranjo segmental envolvendo a microdeleção de cerca de 1 milhão de pares de nucleotídeos no cromossomo 7 herdado da mãe, resultando em haploinsuficiência de no mínimo 13 genes.
SÍNDROME DE TURNER:RELATO DE CASO
Authors: Oliveira Alves Pollyana Cassimiro , Campos Fernandes Regina Célia de Souza , Medina-Acosta Enrique
Published: July 2023

Introdução: A síndrome de Turner é uma cromossomopatia que acomete o sexo feminino, definida por uma ausência completa ou parcial do segundo cromossomo X, acompanhada por uma combinação de aspectos fenotípicos característicos, que incluem a presença de baixa estatura, infantilismo sexual, disgenesia ovariana e malformações principais e secundárias.Objetivo: Descrever um caso de Síndrome de Turner.Método: Revisão de prontuário médico.Relato de caso: Paciente de 2 anos de idade com história de otites de repetição e hipertrofia de adenóide,slinfedema em membros inferiores ao nascimento e as seguintes características físicas: hipodesenvolvimento pondoestatura,limplantação posterior baixa do cabelo, pterigium coli, pescoço curto, micrognatismo, pregas epicânticas e hipertelorismo mamilar. O diagnóstico foi confirmado pela reação em cadeia da polimerase fluorescente quantitativa. Em seguida a paciente foi avaliada quanto à presença de malformações cardíacas e renais, que foram afastadas. No momento em acompanhamento  multidisciplinar.Conclusão: O presente relato ensejou a discussão das manifestações clínicas, métodos diagnósticos , seguimento, bem como das estratégias terapêuticas para a Síndrome de Turner.
Revista Científica da Faculdade de Medicina de Campos
Authors: Campos Fernandes Regina Célia de Souza
Published: July 2023

Vol. 4, nº 1, 2009
Associação entre a osteoartrose do joelho e o índice de massa corporal
Authors: E Albuquerque Rodrigo Pires , Campos Fernandes Rafael de Souza , Barretto João Maurício , Carvalho Antônio Carlos Pires , De Moraes Márcio Bimbato , De Abreu Thiago
Published: July 2023

Objetivo: Este estudo correlaciona o índice de massa corporal (IMC) com o grau de comprometimento articular do joelho através de uma análise radiográfica aplicando os critérios da classificação de Ahlbäck modificada. Métodos: Entre dezembro de 2006 e abril de 2007 foi realizado um estudo prospectivo de 148 joelhos sintomáticos (98 pacientes), sendo estes submetidos às incidências radiográficas e à mensuração do índice de massa corporal. Resultados: O método estatístico utilizado foi a análise de covariância (ANCOVA) para verificar se existe diferença significativa no IMC entre os graus de artrose segundo a classificação de Ahlbäck modificada, controlado para o efeito da idade. O teste de Tukey de comparação múltipla foi aplicado para identificar como os graus de artrose diferem entre si para a análise da idade. O critério de determinação de significância adotado foi o nível de 5%. Verificou-se que existe diferença significativa na idade (P = 0,012) entre os graus de artrose segundo Ahlbäck. Pelo teste de Tukey de comparação múltipla identificou-se que o grau I apresentou idade média significativamente menor que os graus II, III, IV. Pela análise de covariância, observou-se que não existe diferença significativa no IMC (P = 0,19) entre os graus de artrose segundo Ahlbäck, controlado para o efeito da idade. Conclusão: Observamos pelas médias ajustadas que existe uma tendência do IMC aumentar com o grau de artrose, sugerindo predisposição para desenvolvimento de artrose precoce em pacientes com IMC elevado.
A epidemia da desinformação
Authors: Freitas Nélio Artiles
Published: July 2023

A epidemia da desinformação.
Os munícipes de Campos dos Goytacazes (RJ), Brasil, estão ficando cada vez mais órfãos, porém de pais ?vivos?
Authors: Medina-Acosta Enrique
Published: July 2023

Os munícipes de Campos dos Goytacazes (RJ), Brasil,estão ficando cada vez mais órfãos, porém de pais ?vivos?
Mielolipoma de supra-renal. Relato de caso
Authors: Cunha Otávio Costa , Fernandes Constantino Campos , Machado Lutero M. , Belitardo Marcelo G. , Azevedo Marcelo N. , Lourenço Rogério B. , Teixeira João Paulo B.
Published: July 2023

Introdução: O mielolipoma é um tumor benigno do córtex da supra-renal composto de tecido adiposo maduro e ilhotas de tecido hematopoiético, de ocorrência pouco freqüente. O diagnóstico quase sempre é estabelecido de forma casual em explorações radiológicas realizadas por outras patologias, uma vez que clinicamente é assintomático e sem atividade hormonal. Objetivo: Relatar o caso de um mielolipoma de suprarenal diagnosticado incidentalmente durante exame ultrasonográfico. Método: Revisão de prontuário. Relato de caso: Paciente de 56 anos de idade, sexo feminino, durante investigação de dor abdominal através de ultra-sonografia teve diagnosticada a presença de massa na região supra-renal direita. A tomografia computadorizada confirmou este achado, sendo indicada cirurgia para ressecção da supra-renal. Estudo histológico foi compatível com mielolipoma. Conclusão: O mielolipoma de supra-renal é um tumor raro, geralmente assintomático e na maior parte dos casos descoberto acidentalmente durante exploração radiológica. O presente relato ilustra tal afirmação e sinaliza para a necessidade de sua inclusão no diagnóstico diferencial dos tumores de retroperitônio e de supra-renal.
Febre reumática com manifestações clínicas pouco comuns: relato de caso.
Authors: Campos Alexandre Azevedo , Pereira Luciana Vandesteen , Campos Fernandes Regina Célia de Souza
Published: July 2023

Introdução: O envolvimento multissistêmico (isto é, a presença de artrite, cardite e a coréia) é comumente reconhecido na febre reumática aguda. Entretanto os comprometimentos renal e pleural têm merecido pouco destaque. Objetivo: Relatar um caso de febre reumática com aspectos clínicos não clássicos: presença de alteração renal, envolvimento pleural na ausência de insuficiência cardíaca; curto intervalo de tempo entre a faringite estreptocócica e as manifestações articulares; além do envolvimento de pequenas articulações. Método: Revisão de prontuário. Relato de caso: Adolescente de 11 anos foi admitida com dores nas pernas e febre. Há 5 dias usava amoxicilina para controle de faringite estreptocócica. Apresentou episódio de hematúria macroscópica, poliartrite migratória envolvendo inclusive pequenas articulações das mãos, cardite e pequena coleção pleural à esquerda. As manifestações da paciente preencheram os critérios de Jones para o diagnóstico de febre reumática: 2 maiores e todos os menores. A infecção estreptocócica foi confirmada pela ASLO e a menor respondeu ao uso da aspirina e prednisona. Conclusão: O diagnóstico da febre reumática não se baseia apenas em exames laboratoriais, mas sim e principalmente em critérios clínicos. A ocorrência de manifestações atípicas representa uma dificuldade adicional para o estabelecimento do mesmo. Há que se fazer uma análise judiciosa das manifestações clínicas, sem a qual pode haver grave prejuízo da qualidade de vida dos menores afetados e elevados gastos para a Saúde Pública.
Síndrome de Edwards: relato de caso
Authors: Machado Filipe Brum , Faes Luciana , A. Dias Laura de Fátima , Medina-Acosta Enrique
Published: July 2023

Introdução: A incidência de casos de trissomia do cromossomo 18 (Síndrome de Edwards), a segunda trissomia autossômica mais freqüente, oscila entre 1/3000 a 1/8000 nascidos vivos. Essa aneuploidia resulta em malformações severas, profundo retardo mental e alta taxa de mortalidade. Objetivos: Relatar um caso neonatal de Síndrome de Edwards, enfatizando as vantagens de confirmação diagnóstica rápida por meio da técnica Quantitativa Fluorescente da Reação em Cadeia da Polimerase (QF-PCR). Método: Revisão de prontuário Relato de caso: Prematura do sexo feminino, com idade gestacional de 31 semanas, nascida de parto cesariano e pesando 930g. Idade materna 33 anos. A recém-nascida foi transferida para Unidade de Terapia Intensiva (UTI) Neonatal por apresentar asfixia perinatal, insuficiência respiratória, doença de membrana hialina e cardiopatia congênita. As alterações fenotípicas levaram à hipótese diagnóstica de Trissomia 18. A suspeita foi confirmada por QF-PCR em apenas 24 horas e por citogenética convencional em 15 dias. Conclusões: Em gestações de risco de aneuploidias e suspeita clínica no pré-natal e/ou quando há alterações fenotípicas sugestivas após o nascimento a solicitação do teste molecular rápido é de grande valia.