bluuebunny/crossref_metadata_2025 huggingface dataset:
Cataract surgery reduces intraocular pressure but not posture-induced intraocular pressure changes in patients with angle-closure glaucoma
Authors: Chang Pei-Yao , Wang Jia-Kang , Weng Hsin-Yu , Chang Shu-Wen
Published: October 2019

Cataract surgery leads to a sustained decrease in sitting intraocular pressure (IOP) in patients with angle-closure glaucoma (ACG). The purpose of this study is to evaluate whether cataract surgery can also reduce postural IOP changes. We prospectively examined 106 eyes from 53 patients with narrow angles scheduled for phacoemulsification. IOP was measured in the sitting, supine, and lateral decubitus positions using an ICare rebound tonometer before and 1 week, 1 month, and 3 months postoperatively. The mean baseline IOP in the sitting and lateral decubitus positions was 17.9 ± 4.8 mmHg and 21.43 ± 6.44 mmHg, which significantly reduced to 13.52 ± 3.8 and 17.46 ± 3.62, respectively, 3 month postoperatively (p < 0.001). However, postural IOP change (lateral decubitus minus sitting) at 3 months postoperatively was not significantly different from that at the baseline (3.17 ± 2.63 vs. 3.53 ± 3.38 mmHg, p = 0.85). Postural IOP change was not associated with preoperative sitting IOP, anterior chamber depth, axial length, fixed pupil, or presence of glaucomatous optic neuropathy. Patients with higher preoperative IOP exhibited greater IOP reduction after cataract surgery in every posture (p < 0.0001). In conclusion, cataract surgery reduces IOP in all postures among patients with ACG; however, it does not reduce the magnitude of postural IOP change.
Quantitative analysis of three-dimensional morphology and membrane dynamics of red blood cells during temperature elevation
Authors: Jaferzadeh Keyvan , Sim MinWoo , Kim NamGon , Moon InKyu
Published: October 2019

The optimal functionality of red blood cells is closely associated with the surrounding environment. This study was undertaken to analyze the changes in membrane profile, mean corpuscular hemoglobin (MCH), and cell membrane fluctuations (CMF) of healthy red blood cells (RBC) at varying temperatures. The temperature was elevated from 17 °C to 41 °C within a duration of less than one hour, and the holograms were recorded by an off-axis configuration. After hologram reconstruction, we extracted single RBCs and evaluated their morphologically related features (projected surface area and sphericity coefficient), MCH, and CMF. We observed that elevating the temperature results in changes in the three-dimensional (3D) profile. Since CMF amplitude is highly correlated to the bending curvature of RBC membrane, temperature-induced shape changes can alter CMF’s map and amplitude; mainly larger fluctuations appear on dimple area at a higher temperature. Regardless of the shape changes, no alterations in MCH were seen with temperature variation.
Genome-wide identification and expression analyses of the LEA protein gene family in tea plant reveal their involvement in seed development and abiotic stress responses
Authors: Jin Xiaofang , Cao Dan , Wang Zhongjie , Ma Linlong , Tian Kunhong , Liu Yanli , Gong Ziming , Zhu Xiangxiang , Jiang Changjun , Li Yeyun
Published: October 2019

Late embryogenesis abundant (LEA) proteins are widely known to be present in higher plants and are believed to play important functional roles in embryonic development and abiotic stress responses. However, there is a current lack of systematic analyses on the LEA protein gene family in tea plant. In this study, a total of 48 LEA genes were identified using Hidden Markov Model profiles in C. sinensis, and were classified into seven distinct groups based on their conserved domains and phylogenetic relationships. Genes in the CsLEA_2 group were found to be the most abundant. Gene expression analyses revealed that all the identified CsLEA genes were expressed in at least one tissue, and most had higher expression levels in the root or seed relative to other tested tissues. Nearly all the CsLEA genes were found to be involved in seed development, and thirty-nine might play an important role in tea seed maturation concurrent with dehydration. However, only sixteen CsLEA genes were involved in seed desiccation, and furthermore, most were suppressed. Additionally, forty-six CsLEA genes could be induced by at least one of the tested stress treatments, and they were especially sensitive to high temperature stress. Furthermore, it was found that eleven CsLEA genes were involved in tea plant in response to all tested abiotic stresses. Overall, this study provides new insights into the formation of CsLEA gene family members and improves our understanding on the potential roles of these genes in normal development processes and abiotic stress responses in tea plant, particularly during seed development and desiccation. These results are beneficial for future functional studies of CsLEA genes that will help preserve the recalcitrant tea seeds for a long time and genetically improve tea plant.
Advances in nanoplasmonic biosensors for clinical applications
Authors: Mauriz Elba , Dey Priyanka , Lechuga Laura M.
Published: October 2019

Plasmonic biosensors can be conveniently used as portable diagnostic devices for attaining timely and cost-effective clinical outcomes. Nanoplasmonics technology opens the way for sensor miniaturization, multiplexing and point of care testing.
Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow
Authors: Heap Rachel E. , Segarra-Fas Anna , Blain Alasdair P. , Findlay Greg M. , Trost Matthias
Published: October 2019

A fast and robust sample preparation method for MALDI TOF MS analysis of whole mammalian cells and phenotypic profiling of mESCs.
A fast nucleic acid extraction system for point-of-care and integration of digital PCR
Authors: Yin Juxin , Hu Jiumei , Sun Jingjing , Wang Ben , Mu Ying
Published: October 2019

This work showcases a PTFE-based nucleic acid extraction system for point-of-care and integration of digital PCR.
Separation and characterization of KRas proteins and tryptic peptides using enhanced-fluidity liquid chromatography tandem mass spectrometry
Authors: Bian Juan , Olesik Susan V.
Published: October 2019

A sensitive method for detecting the K-Ras protein and its mutation was developed using enhanced-fluidity, reversed-phase liquid chromatography-mass spectrometry.
Chitosan grafted onto Fe3O4@poly(N-vinylcaprolactam) as a new sorbent for detecting Imatinib mesylate in biosamples using UPLC-MS/MS
Authors: Sahebi Hamed , Pourmortazavi Seied Mahdi , Zandavar Hamed , Mirsadeghi Somayeh
Published: October 2019

Fe3O4 nanoparticles with chitosan grafted onto poly(N-vinylcaprolactam) copolymers are synthesized and showed dual sensitivity to temperature and pH.
A novel electrochemical sensor based on microporous polymeric nanospheres for measuring peroxynitrite anion released by living cells and studying the synergistic effect of antioxidants
Authors: Liu Fuxin , Li Lin , Zhang Binyan , Fan Weizhou , Zhang Rongjin , Liu Guoan , Liu Xiuhui
Published: October 2019

A novel electrochemical ONOO− sensor is constructed and applied to study the synergistic effect of antioxidants on removal of ONOO−.
A promising water-in-salt electrolyte for aqueous based electrochemical energy storage cells with a wide potential window: highly concentrated HCOOK
Authors: Liu Ting , Tang Lujie , Luo Haowei , Cheng Shuang , Liu Meilin
Published: October 2019

Recently, water-in-salt electrolytes have been widely reported because of their ability in broadening the potential window of aqueous based energy storage devices.
Simultaneous laser-induced synthesis and micro-patterning of a metal organic framework
Authors: Armon Nina , Greenberg Ehud , Edri Eitan , Kenigsberg Avraham , Piperno Silvia , Kapon Omree , Fleker Ohad , Perelshtein Ilana , Cohen-Taguri Gili , Hod Idan , Shpaisman Hagay
Published: October 2019

Micro-patterning of a metal organic framework (MOF) from a solution of precursors is achieved by local laser heating, alleviating the need for pre-preparation and stabilization.
Assessing the usefulness of transition metal carbides for hydrogenation reactions
Authors: Prats Hector , Piñero Juan José , Viñes Francesc , Bromley Stefan T. , Sayós Ramón , Illas Francesc
Published: October 2019

Transition Metal Carbides (TMCs) are proposed as viable replacements for scarce and expensive late Transition Metals (TMs) for heterogeneous catalysis involving hydrogenation reactions or steps.
Asymmetric synthesis of atropisomeric pyrazole via an enantioselective reaction of azonaphthalene with pyrazolone
Authors: Yuan Huijun , Li Yao , Zhao Hanhui , Yang Zhihong , Li Xin , Li Wenjun
Published: October 2019

The first catalytic asymmetric reaction of azonaphthalene with pyrazolone has been established. A wide range of axially chiral pyrazole derivatives have been achieved in good yields (68–99%) with excellent enantioselectivities (83–98% ee) by utilizing chiral phosphoric acid as a catalyst.
Handy fluorescent paper device based on a curcumin derivative for ultrafast detection of peroxide-based explosives
Authors: Zhu Qiu-Hong , Zhang Guo-Hao , Yuan Wen-Li , Wang Shuang-Long , He Ling , Yong Fang , Tao Guo-Hong
Published: October 2019

A useful and inexpensive fluorescent paper-based device was fabricated for ultrafast sensing of peroxide-based explosives.
Phase and morphology evolution of luminescent NaLnF4 (Ln = La to Yb) micro-crystals: understanding the ionic radii and surface energy-dependent solution growth mechanism
Authors: Sun Xinwen , Wang Xinwei , Chen Bing , Zhao Feiyu , Xu Xiuxia , Ren Kai , Lu Yunhao , Qiao Xvsheng , Qian Guodong , Fan Xianping
Published: October 2019

Lanthanide (Ln)-based NaLnF4 micro-crystals (MCs) exhibit great advantages and strong feasibility for integration into micron-sized photonic devices.
Li2Na2TiP2O9: an ordered Na4TiP2O9-type crystal with ion-exchange properties
Authors: Duan Meihong , Li Rukang
Published: October 2019

Cation-tuned synthesis of an ordered open-frame Na4TiP2O9-type crystal, Li2Na2TiP2O9, with multiple channels (occupied or unoccupied) exhibiting ion-exchange properties.
Chloride binding capacity of LDHs with various divalent cations and divalent to trivalent cation ratios in different solutions
Authors: Chen Mengzhu , Wu Fang , Yu Linwen , Cai Yuxin , Chen Hang , Zhang Mingtao
Published: October 2019

Chlorides were bonded by LDHs due to ion exchange and surface adsorption. Carbonation resulted in the debonding of the chloride bond by ion exchange, however, surface adsorption was not affected by carbonation.
Strategies for extending charge separation in colloidal nanostructured quantum dot materials
Authors: Maity Partha , Ghosh Hirendra N.
Published: October 2019

Different processes are involved in a quantum dot sensitized solar cell (QDSC). This article reviews the probable ways to extend charge separation in colloidal nanocrystals for the elevation of solar to electrical energy conversion efficiency in QDSCs.
An XAFS study of Cs adsorption by the precipitation bands of Mn–Fe-based Prussian blue analogues spontaneously formed in agarose gel
Authors: Hayashi Hisashi , Aoki Saya , Takaishi Mao , Sato Yui , Abe Hitoshi
Published: October 2019

The adsorption of Cs+ ions by the precipitation bands of a Mn–Fe based Prussian blue analogue that form spontaneously in agarose gel was investigated by XAFS spectroscopy coupled with SEM and XRF distribution analysis.
Comparing the performances of various density functionals for modelling the mechanisms and kinetics of bimolecular free radical reactions in aqueous solution
Authors: Nikšić-Franjić Ivana , Ljubić Ivan
Published: October 2019

We systematically tested the performances of 18 density functionals for the mechanisms and kinetics of reactions of the α-hydroxyisopropyl radical with 9 organic substrates.
Determination of optimum optoelectronic properties in vertically stacked MoS2/h-BN/WSe2 van der Waals heterostructures
Authors: Tan Shilin , Zhao Yipeng , Dong Jiansheng , Yang Guowei , Ouyang Gang
Published: October 2019

Inserting an insulator at the interface in vdW heterostructure solar cell unit can improve the photoelectric conversion efficiency, and the insulator has an optimal thickness.
Soft modes of the dielectric response in the twist–bend nematic phase and identification of the transition to a nematic splay bend phase in the CBC7CB dimer
Authors: Merkel K. , Kocot A. , Welch C. , Mehl G. H.
Published: October 2019

Two collective processes resulting from distortion of the heliconical structure of the twist–bend nematic phase of an achiral dimer: one tilt mode due to distortions of the conical angle and second related to long range fluctuation of the cone phase.
Single atom electrocatalysts supported on graphene or graphene-like carbons
Authors: Fei Huilong , Dong Juncai , Chen Dongliang , Hu Tiandou , Duan Xidong , Shakir Imran , Huang Yu , Duan Xiangfeng
Published: October 2019

The synthetic strategies, structural identification and electrocatalytic applications of single atom catalysts supported on graphene or graphene-like carbons are reviewed.
Improvements to the production of ZIF-94; a case study in MOF scale-up
Authors: Johnson Timothy , Łozińska Magdalena M. , Orsi Angelica F. , Wright Paul A. , Hindocha Sheena , Poulston Stephen
Published: October 2019

Improving the production of the ZIF-94 framework – aiming to boost safety, reduce environmental impact and cost while maintaining performance.
ReGreen SPPS: enabling circular chemistry in environmentally sensible solid-phase peptide synthesis
Authors: Pawlas Jan , Rasmussen Jon H.
Published: October 2019

A cost and synthetic efficient method that enables facile reagent and solvent recycling in SPPS using cross-linked polystyrene resins in greener solvents is reported.
Rapid access to cinnamamides and piper amides via three component coupling of arylaldehydes, amines, and Meldrum's acid
Authors: Ghosh Santanu , Jana Chandan K.
Published: October 2019

A practical one-step method for the synthesis of cinnamamides and piper amides without the aid of coupling reagents, oxidants, catalysts or any other additives has been developed.
A multi-objective optimization-extended techno-economic assessment: exploring the optimal microalgal-based value chain
Authors: Thomassen Gwenny , Van Dael Miet , You Fengqi , Van Passel Steven
Published: October 2019

The integration of a multi-objective optimization and an environmental techno-economic assessment method enables the identification of optimal scenarios for green technologies from both an economic and an environmental perspective.
A simple single-stage extraction method for Mo separation from geological samples for isotopic analysis by MC-ICP-MS
Authors: Feng Lanping , Zhou Lian , Hu Wenfeng , Zhang Wen , Li Baichan , Liu Yongsheng , Hu Zhaochu , Yang Lu
Published: October 2019

Simple, fast and efficient column separation of Mo from geological sample matrices using the TRU resin.
Slope ratio calibration for analysis of plant leaves by laser-induced breakdown spectroscopy
Authors: Nunes Lidiane C. , Rocha Fábio R. P. , Krug Francisco J.
Published: October 2019

A new calibration strategy based on the increase of the ablated mass with the number of accumulated laser pulses on a single solid calibration standard is proposed for laser-induced breakdown spectroscopy (LIBS).
Bifunctional earth-abundant phosphate/phosphide catalysts prepared via atomic layer deposition for electrocatalytic water splitting
Authors: Rongé Jan , Dobbelaere Thomas , Henderick Lowie , Minjauw Matthias M. , Sree Sreeprasanth Pulinthanathu , Dendooven Jolien , Martens Johan A. , Detavernier Christophe
Published: October 2019

The development of active and stable earth-abundant catalysts for hydrogen and oxygen evolution is one of the requirements for successful production of renewable fuels.
Visible-light-driven catalytic oxidation of aldehydes and alcohols to nitriles by 4-acetamido-TEMPO using ammonium carbamate as a nitrogen source
Authors: Nandi Jyoti , Leadbeater Nicholas E.
Published: October 2019

A mild and efficient route to prepare nitriles from aldehydes by combining photoredox catalysis with oxoammonium cations is reported. The methodology is also extended to the one-pot two-step conversion of alcohols to nitriles.
pH-Controlled motions in mechanically interlocked molecules
Authors: Zhou He-Ye , Han Ying , Chen Chuan-Feng
Published: October 2019

This review summarizes pH-controlled mechanical motions including translocation in rotaxanes, circumrotation in catenanes and other motions in more sophisticated mechanomolecules.
A novel ratiometric fluorescent probe for the selective determination of HClO based on the ESIPT mechanism and its application in real samples
Authors: Li Jingrui , Gong Aijun , Shi Guoqing , Chai Chengwen
Published: October 2019

Based on the ESIPT fluorescence mechanism, herein, a novel ratiometric fluorescent probe was designed and synthesized for the detection of HClO.
Highly dispersed Pt catalyst supported on nanoporous carbon derived from waste PET bottles for reductive alkylation
Authors: Wenlong Yu , Zhe Chen , Shitao Yu , Junwei Ding , Yuling Shan , Fusheng Liu , Ming Li
Published: October 2019

Nanoporous carbon (NPC) derived from waste polyethyleneterephthalate (PET) bottles was prepared by a MgO-templated method and employed as a support for a highly dispersed platinum catalyst.
Layer dependence of the photoelectrochemical performance of a WSe2 photocathode characterized using in situ microscale measurements
Authors: Zhang Yu , Xiao Jingwei , Xie Xi , Chen Huanjun , Deng Shaozhi
Published: October 2019

The performance of WSe2 PEC cathode increased with decreasing number of layers. Monolayer WSe2 exhibited best PEC characteristics and IPCE efficiency. The basal-plane of WSe2 sheet had the same PEC catalytic activity with the edge sites.
Asymmetric supercapacitors with excellent rate performance by integrating Co(OH)F nanorods and layered Ti3C2Tx paper
Authors: Chen Si , Zhou Xuejiao , Ma Xinzhi , Li Lu , Sun Panpan , Zhang Mingyi
Published: October 2019

Here we describe an aqueous asymmetric supercapacitor assembled using Co(OH)F nanorods on Ni foam (Co(OH)F@NF) as the positive electrode and layered Ti3C2Tx paper on Ni foam (Ti3C2Tx@NF) as the negative electrode.
Process parameter sensitivity investigation on the reaction crystallization production of K2SO4 with salt lake leonite ore
Authors: Chen Hang , Zhu Min , Song Xingfu , Yu Jianguo
Published: October 2019

Reaction crystallization process optimization for the production of K2SO4 with low-grade salt lake leonite ore in Qinghai, China.
NiCoFe alloy multishell hollow spheres with lattice distortion to trigger efficient hydrogen evolution in acidic medium
Authors: Sial Muhammad Aurang Zeb Gul , Liu Shiyu , Zou Jizhao , Luo Qi , Saleemi Awais Siddique , Liu Lijia , Zhao Fenglin , Yao Yuechao , Zeng Xierong
Published: October 2019

NiCoFe alloy multishell hollow spheres supported on graphitic carbons with lattice defects are prepared, and they show high activity for hydrogen evolution in acidic medium.
Travelling waves on photo-switchable patterned liquid crystal polymer films directed by rotating polarized light
Authors: Liu Ling , Broer Dirk J. , Onck Patrick R.
Published: October 2019

In this paper we generate propagating surface waves on azobenzene-modified liquid crystalline polymer films that only requires flood exposure by rotating the linear polarization of light.
Pillared-layered metal–organic frameworks for mechanical energy storage applications
Authors: Wieme Jelle , Rogge Sven M. J. , Yot Pascal G. , Vanduyfhuys Louis , Lee Su-Kyung , Chang Jong-San , Waroquier Michel , Maurin Guillaume , Van Speybroeck Veronique
Published: October 2019

Breathing metal–organic frameworks (MOFs) are promising candidates for mechanical energy storage. Theoretical and experimental measurements reveal the potential of pillared-layered MOFs.
A new cathode material synthesized by a thiol-modified metal–organic framework (MOF) covalently connecting sulfur for superior long-cycling stability in lithium–sulfur batteries
Authors: Liu Xu , Wang Shi , Wang Ailian , Wang Zhinan , Chen Jie , Zeng Qinghui , Chen Pingping , Liu Wei , Li Zengxi , Zhang Liaoyun
Published: October 2019

A stabilized sulfur cathode with CNT@MOF covalently connected with sulfur was fabricated for the first time.
Br-containing alkyl ammonium salt-enabled scalable fabrication of high-quality perovskite films for efficient and stable perovskite modules
Authors: Xu Zhongyuan , Chen Ruihao , Wu Yazhuo , He Ruiqin , Yin Jun , Lin Wei , Wu Binghui , Li Jing , Zheng Nanfeng
Published: October 2019

The incorporation of a Br-containing tetrabutylammonium salt into perovskite precursors demonstrates superior advantages in both crystallization and large-area uniformity control during the scalable blade-coating of perovskite films.
Probing into the origin of an electronic conductivity surge in a garnet solid-state electrolyte
Authors: Song Yongli , Yang Luyi , Tao Lei , Zhao Qinghe , Wang Zijian , Cui Yanhui , Liu Hao , Lin Yuan , Pan Feng
Published: October 2019

Through studying the electronic conductivity of a garnet electrolyte, a model to describe the electron transfer within electrolytes is proposed.
Recent advances of ratiometric electrochemiluminescence biosensors
Authors: Huo Xiao-Lei , Lu Hai-Jie , Xu Jing-Juan , Zhou Hong , Chen Hong-Yuan
Published: October 2019

Ratiometric electrochemiluminescence (ECL) assays have been widely applied in biosensing because of eliminated outside interferences and improved reliability in detection.
Molecular isomerization triggered by H2S to an NIR accessible first direct visualization of Ca2+-dependent production in living HeLa cells
Authors: Wen Ying , Huo Fangjun , Wang Junping , Yin Caixia
Published: October 2019

Few studies determined the role of intracellular labile Ca2+ in H2S homeostasis.
Order–disorder transformation of intercalated cations triggering huge negative thermal expansion, switchable dielectrics and ion conduction near room temperature in a 2D vanadium oxide hybrid
Authors: Yao Zhi-Yuan , Qian Yin , Ren Qiu , Zhang Guo-Qin , Zhang Jin , Liu Wen-Long , Luo Hong-Bin , Ren Xiao-Ming
Published: October 2019

A 2D vanadium oxide hybrid crystal shows an order–disorder phase transition at ∼328 K/316 K upon heating/cooling, which triggers huge negative thermal expansion, switchable dielectrics and ion conduction near room temperature.
A strategy for developing thermal-quenching-resistant emission and super-long persistent luminescence in BaGa2O4:Bi3+
Authors: Li Huimin , Cai Jize , Pang Ran , Liu Guanyu , Zhang Su , Jiang Lihong , Li Da , Li Chengyu , Feng Jing , Zhang Hongjie
Published: October 2019

A novel BaGa2O4:0.02Bi3+ phosphor with excellent thermal-quenching-resistant emission and super-long persistent luminescence has been synthesized and systematically investigated.
Multi-mode structural-color anti-counterfeiting labels based on physically unclonable amorphous photonic structures with convenient artificial intelligence authentication
Authors: He Xueying , Gu Yanan , Yu Borong , Liu Zhiwei , Zhu Kuan , Wu Na , Zhao Xu , Wei Yu , Zhou Jinming , Song Yanlin
Published: October 2019

The first physically unclonable anti-counterfeiting label based on structural colors was enabled by interfacing amorphous photonic structures with artificial intelligence.
Alteration of Nabali Baladi Extra Virgin Olive Oil (EVOO) chemical parameters as a function of air and sunlight exposure
Authors: Houshia Orwa Jaber , abuEid Mohamad , Zaid Oday , Shqair Hazem , Zaid Motasem , Nashariti Wala , Noor Batool , Al-Rimwai Fuad
Published: October 2019

An experimental investigation performed to study changes to the olive oil quality as a function of sunlight and air. The chemical property changes of Nabali Baladi olive oil were monitored as a function of sun/air exposure and recorded in terms of free acidity, peroxide value, ΔK, chlorophyll and carotenoids. Three batches of samples (run in triplicates) that were classified extra virgin olive oil from previous years 2014, 2015, and 2016 were studied. The results showed that as sun/air-exposure time interval increases, the acidity, the peroxide value and ΔK increase rapidly, and the concentration of the carotenoids and chlorophyll decreased. Exposing extra virgin olive to sunlight/air for long periods of time results in rapid deterioration of its quality. The statistical calculations aided in confirmation and support of the experimental results.
The EDGI new take on EDGE: EUS-directed transgastric intervention (EDGI), other than ERCP, for Roux-en-Y gastric bypass anatomy: a multicenter study
Authors: Krafft Matthew R. , Hsueh William , James Theodore W. , Runge Thomas M. , Baron Todd H. , Khashab Mouen A. , Irani Shayan S. , Nasr John Y.
Published: October 2019

Background and study aims Indications for accessing the duodenum, and/or excluded stomach in Roux-en-Y gastric bypass (RYGB) patients extend beyond diagnosis and treatment of pancreaticobiliary maladies. Given the high technical and clinical success of EUS-directed transgastric ERCP (EDGE) in RYGB anatomy, we adopted this transgastric (anterograde) approach to evaluate and treat luminal and extraluminal pathology in and around the excluded gut in RYGB patients. EUS-directed transgastric intervention (“EDGI”), other than ERCP, is the terminology we have chosen to describe this heterogenous group of transgastric diagnostic and/or interventional endoscopic procedures (transgastric interventions) performed via a lumen-apposing mental stent (LAMS) in select patients with RYGB.

Patients and methods A multicenter (n = 4), retrospective study of RYGB patients with suspected luminal or extraluminal pathology, in or around the duodenum and/or excluded stomach, underwent EDGI using LAMS between December 2015 and January 2019.

Results A total of 14 patients (78.6 % women; mean age, 55.7 + 12.4 years) underwent EDGI via LAMS. Technical and clinical success rates of EDGI were 100 %. The most common transgastric interventions were diagnostic EUS of extraluminal pathology (n = 6, 42.7 %) and endoscopic biopsy of gastroduodenal luminal abnormalities (n = 5, 35.7 %). Two moderate-severity adverse events due to LAMS maldeployment occurred during EUS-JG creation (14.3 %), and each instance was successfully rescued with a bridging stent.

Conclusions A variety of gastroduodenal luminal and extraluminal disorders in RYGB patients can be effectively diagnosed and managed using EDGI via LAMS.
Diagnostic yield of Franseen and Fork-Tip biopsy needles for endoscopic ultrasound-guided tissue acquisition: a meta-analysis
Authors: Facciorusso Antonio , Del Prete Valentina , Buccino Vincenzo Rosario , Purohit Purvi , Setia Puneet , Muscatiello Nicola
Published: October 2019

Background and study aims Although newer needle designs are thought to improve diagnostic outcomes of endoscopic ultrasound-guided fine-needle biopsy, there is limited evidence on their diagnostic performance. The aim of this meta-analysis was to provide a pooled estimate of the diagnostic performance and safety profile of Franseen and Fork-tip fine-needle biopsy needles.

Patients and methods Computerized bibliographic search on the main databases was performed through March 2019. The primary endpoint was sample adequacy. Secondary outcomes were diagnostic accuracy, optimal histological core procurement, mean number of needle passes, pooled specificity and sensitivity. Safety data were also analyzed.

Results Twenty-four studies with 6641 patients were included and pancreas was the prevalent location of sampled lesions. Overall sample adequacy with the two newer needles was 94.8 % (93.1 % – 96.4 %), with superiority of Franseen needle over Fork-tip (96.1 % versus 92.4 %, P < 0.001). Sample adequacy in targeting pancreatic masses was 95.6% and both needles produced results superior to fine-needle aspiration (FNA) (odds ratio 4.29, 1.49 – 12.35 and 1.79, 1.01 – 3.19 with Franseen and Fork-tip needle, respectively). The rate of histological core procurement was 92.5%, whereas diagnostic accuracy and sensitivity were 95 % and 92.8 %, again with no difference between the two needles. Number of needle passes was significantly lower in comparison to FNA (mean difference: –0.42 with Franseen and –1.60 with Fork-tip needle). No significant adverse events were registered.

Conclusion Our meta-analysis speaks in favor of use of newer biopsy needles as a safe and effective tool in endoscopic ultrasound-guided tissue acquisition.
Medical Needling – Effekt auf hypertrophe Verbrennungsnarben hinsichtlich der Hautspannung und -elastizität
Authors: Busch Kay Hendrik , Aliu Antigona , Bender Richard , Walezko Nicole , Aust Matthias C.
Published: October 2019

Hintergrund Verbrennungsnarben stellen ein ernstzunehmendes physisches und psychisches Problem für die betroffenen Personen dar. Klinische Studien und wissenschaftliche Forschungen haben gezeigt, dass Medical Needling die Narbenbeschaffenheit hinsichtlich der Parameter Feuchtigkeit, Elastizität, transepidermalen Wasserverlust und Erythem verbessert. Gleichzeitig werden die Patienten mit einer vergleichsweise risikoarmen Therapie ohne postinterventionelle Komplikationen konfrontiert.

Ziel Ziel dieser Studie war es, den Einfluss von Medical Needling auf die Qualität ausgereifter hypertropher Narben hinsichtlich der Parameter Spannung und Elastizität zu testen. Insgesamt wurden 20 Patienten im Durchschnittsalter von 34,6 Jahren mit Verbrennungen zweiten und dritten Grades behandelt. Narben, welche mindestens 2 Jahre alt waren, wurden in unsere Studie involviert.

Methoden Medical Needling wird mit einem Roller durchgeführt, welcher mit Nadeln von 3 mm Länge besetzt ist. Mit konstantem Druck wird dieser vertikal, diagonal und horizontal über das zu behandelnde Hautareal gerollt. Die dermale Punktion verursacht Mikroläsionen mit anschließender minimaler, intradermaler Blutung. Dieser mechanische Prozess stimuliert mittels endogener Wachstumsfaktoren eine von der Dermis ausgehende Regeneration der Haut. Patienten wurden postoperativ bis zu 12 Monate nach der Behandlung anhand objektivierbarer Messverfahren untersucht. Gleichzeitig wurde der Parameter „Patientenzufriedenheit“ als subjektives, qualitatives Maß für eine Verbesserung der Narbenqualität erhoben.

Ergebnisse Die objektiven Messdaten ergaben, dass Medical Needling sowohl eine Reduktion der Spannung von straffen hypertrophen Narben, als auch eine erhöhte Festigkeit bei überdehnten Narben bewirkt. Tiefgreifende Läsionen mit Verlust elastischer Elemente bedingen rigide Narben, welche durch eine Behandlung mit Medical Needling an vitalen Eigenschaften sowie physiologischer Elastizität gewannen.

Schlussfolgerung Medical Needling erweist sich als ein vielversprechender Therapieansatz zur Behandlung hypertropher Narben mit pathologischen Veränderungen der Hautspannung und -elastizität.
Rehabilitation der brandverletzten Hand
Authors: Ziegenthaler Hans
Published: October 2019

Verletzungen speziell an den Händen finden sich bei thermischen Unfällen
überproportional häufig. Ziel einer ICF-orientierten Rehabilitation des
Brandverletzten ist es, dem außergewöhnlich sensorisch und funktionell
entwickelten Greiforgan Hand möglichst viel an Funktionalität zurückzugeben bzw.
alltagspraktikable Kompensationsmechanismen zu erarbeiten.

Dem anfangs bunten klinischen Bild mit Ödemen, Kontrakturen, Fehlstellungen sowie
hypertropher Narbenbildung und Epitheldefekten stehen vielfach hohe Erwartungen
an alltagsrelevante Funktionalität und Ästhetik des Brandverletzten
entgegen.

Nur durch multimodale Therapieoptionen und ein interdisziplinäres Denken kann das
Reha-Team dieser besonderen Aufgabe gerecht werden.
Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling of Effect of Naringenin and Its Surface Modified Nanocarriers on Associated and Core Behaviors of Autism Spectrum Disorders (ASD)
Authors: Bhandari Ranjana , Paliwal Jyoti K. , Kuhad Anurag
Published: October 2019

The pharmacokinetic and pharmacodynamic (PK-PD) model was developed to describe the relationship between plasma/brain concentration of naringenin and its nanocarriers with behavioral and biochemical alterations in a rat model of autism spectrum disorders (ASD). Behavioral parameters like sensorimotor dysfunction, hyperlocomotion, anxiety-like behavior, social interaction, and repetitive behavior were investigated by rotarod, actophotometer, open-field, reciprocal social interaction, and repetitive self-grooming test respectively. Naringenin was administered in doses (25, 50, and 100 mg/kg) and in the form of its uncoated and glutathione as well as tween 80–coated PLGA nanocarriers (25 mg/kg) thrice daily (8 hourly). Sigmoid Emax model was applied to study the relationship between the concentration of naringenin in plasma/brain and behavioral effects (in terms of sensorimotor dysfunction, locomotor activity, anxiety-like behavior, social interaction ability, repetitive behavior) as well as biochemical changes (plasma levels of TNF-α, MMP-9, and HSP-70, and Pgp at BBB). Model parameters such as Eo, Emax, and EC50 indicate that maximum effect occurred after administration of GSH-coated naringenin nanoparticles and the minimum effect occurred with the 25 mg/kg dose of unencapsulated naringenin. The R2 value of 0.99 and small Akaike information criterion indicate the goodness of fit of the model. The PK-PD modeling done by sigmoid Emax model showed a positive correlation between plasma/brain drug concentration and neuroinflammatory markers as well as behaviors consistent with the ASD phenotype.
Methods for the Synthesis of Piperazine Derivatives Containing a Chiral Bi-2-naphthyl Moiety
Authors: Periasamy Mariappan , Venkanna Boda , Nagaraju Miriyala , Mohan Lakavathu
Published: October 2019

Piperazine derivatives containing 1,1′-bi-2-naphthyl moiety were synthesized starting from 2,2′-dimethoxy-1,1′-bi-naphthalene via acylation using ethyl chlorooxoacetate and subsequent condensation with 1,2-diamines followed by reduction of the corresponding dihydro-2-piperazinone intermediate using the NaBH4/I2 reagent system. The corresponding chiral piperazine derivatives containing bi-2-napthyl moiety was synthesized by asymmetric reduction of ethyl dimethoxy-bi-2-naphthyloxoacetate by chiral oxazoborolidine catalyst prepared in situ using S-diphenylprolinol (S-DPP), B(OCH3)3 and H3B·THF. The resulting diols were mesylated and cyclized using 1,2-diamines to obtain the corresponding chiral piperazine derivatives.
Pathogenesis and Classification of Chiari Malformation Type I Based on the Mechanism of Ptosis of the Brain Stem and Cerebellum: A Morphometric Study of the Posterior Cranial Fossa and Craniovertebral Junction
Authors: Nishikawa Misao , Bolognese Paolo A. , Kula Roger W. , Ikuno Hiromichi , Ohata Kenji
Published: October 2019

Introduction We investigated the mechanism of ptosis of the brain stem and cerebellum (hindbrain) in Chiari malformation type I (CM-I) and classified CM-I according to pathogenesis, based on a morphometric study of the posterior cranial fossa (PCF) and craniovertebral junction (CVJ). We discuss the appropriate surgical treatment for hindbrain ptosis.

Materials and Methods We examined 500 patients with CM-I and 100 healthy control individuals. We calculated the volume of the PCF (VPCF) and measured the axial length of the enchondral parts of the occipital bone and hindbrain. As statistical analyses, for the multiple analyses, heavy palindromic tests were used. Using three independent objective parameters, we tried to classify CM-I.

Results Three independent subtypes were confirmed (CM-I types A, B, and C). CM-I type A (167 cases): normal VPCF, normal volume of the area surrounding the foramen magnum (VSFM), and normal occipital bone size; CM-I type B (178 cases): normal VPCF, small VSFM, and small occipital bone size; and CM-I type C (155 cases): small VPCF, small VSFM, and small occipital bone size.

Conclusions Morphometric analyses of PCF and CVJ were very useful for the investigation of the mechanism of hindbrain ptosis and classifying CM-I according to pathogenesis. CM-I type A included mechanisms other than hindbrain ptosis, for example, CVJ instability, tethered cord, and increased intracranial pressure. CM-I types B and C demonstrated underdevelopment of the occipital bone. For CM-I types B and C, posterior decompression should be performed. For CM-I type A, appropriate surgical management should be selected.
Eosinofilias Pulmonares: Hallazgos que un radiólogo debe conocer
Authors: Couture Juliana , Adri Daniel , Villegas Juan Manuel , Posadas Natalia , Seehaus Alberto
Published: October 2019

Las eosinofilias pulmonares incluyen un amplio espectro de desórdenes. Su diagnóstico definitivo se realiza con la anatomía patológica. No obstante, a través de los antecedentes clínicos, el examen físico y —cada vez de forma más precisa— las imágenes, podemos llegar a una mejor definición de la patología. Hoy en día, la tomografía computada multidetector (TCMD) de alta resolución es el método por imágenes de mayor sensibilidad y especificidad, ya que permite una valoración de la patología pulmonar difusa cada vez más acertada, evitando así métodos más invasivos, aportando detallada información y manifestando lesiones que carecen de una expresión clínica específica por medio de patrones radiológicos característicos.
Microscopic and Chemical Assessments of the Filling Ability in Oval-Shaped Root Canals Using Two Different Carrier-Based Filling Techniques
Authors: Mancino Davide , Kharouf Naji , Hemmerlé Joseph , Haïkel Youssef
Published: October 2019

Objectives The aim of this study was to assess the filling ability in oval-shaped canals using two different carrier-based filling techniques.

Materials and Methods Twenty-four human mandibular premolars with one oval canal were selected. Canals were shaped using WaveOne Gold Primary and ProGlider. Samples were divided into two groups and filled as follows: Thermafil and GuttaCore. The proportions of gutta-percha-filled areas (GPFAs), sealer-filled areas (SFAs), and void areas (VA), at 2 and 5 mm, were analyzed using optical numeric microscope, scanning electron microscope, and energy-dispersive X-ray.

Statistical Analysis Data were compared by Kruskal–Wallis one-way analysis of variance on ranks, with statistical significance set at α = 0.05.

Results At 2 and 5 mm distances from the apex, this study discloses no statistically different filling ability for the two techniques. Concerning each sample treated using both filling systems, the presence of tags was visualized. At working length (WL)-5, and WL-2, the maximum tag penetration depth for the GuttaCore group into the dentinal tubules was, respectively, 96 μm and 48 μm, whereas the values in the thermafil group were 109 μm, and 55 μm, respectively.

Conclusions Our results clearly show that Thermafil and GuttaCore can fill oval-shaped canals in appropriate way. Furthermore, we can state that the GuttaCore obturator allows to preserve the same filling ability than Thermafil obturator, in view of the fact that there was no difference, in terms of GPFA, SFA, and VA between the two different carrier-based obturation techniques.
Transforaminal Intrathecal Access for Injection of Nusinersen in Adult and Pediatric Patients with Spinal Muscular Atrophy
Authors: Shokuhfar Tahaamin , Abdalla Ramez N. , Hurley Michael C. , Nazari Pouya , Ansari Sameer A. , Ajroud-Driss Senda , Kuntz Nancy , Azmi Subhan , Rao Vamshi , Shaibani Ali
Published: October 2019

The main purpose of this article is to assess the safety and efficacy of transforaminal lumbar puncture for the injection of nusinersen (Spinraza) in patients with extensive spinal fusion and/or scoliosis.

A retrospective chart reviews of all spinal muscular atrophy patients (adults and children) were conducted. Demographic data, procedure details, follow-ups, and related complications were recorded.

We performed 85 transforaminal injections in nine pediatric patients (5 male and 4 female) aged between 8 and 17 years (mean = 11 years) and seven adult patients (5 females and 2 males) aged between 24 and 41 years (mean= 30 years). Fluoroscopy guidance was used in 87% of our patients. No major complication was reported.

Fluoroscopy-guided transforaminal nusinersen injection is a safe and successful alternative approach in adult and pediatric patients with severe spinal scoliosis, interlaminar osseous fusion, and spinal fusion hardware.
Ossified Spinal Meningioma: A Case Report and a Review of the Literature
Authors: Taha Mahmoud M. , Alawamry Ahmed , Abdel-Aziz Hesham R.
Published: October 2019

Ossified spinal meningiomas are a rare form of spinal tumors. These tumors increase surgical morbidities due to their hard consistency and strong adhesion to the neural tissue and relatively narrow surgical space. Here, the authors describe the clinical findings, surgical strategies, and histological findings of a patient with an ossified meningioma. Preoperative diagnosis of these tumors can prevent surgical morbidities. Total resection can be curative with the application of meticulous microsurgical techniques.
Changes in Leadership: A 20-Year Study of Trends in Tenure of Chairs of Departments of Ophthalmology
Authors: Kung George P. , Cruz Oscar A. , Israel Heidi
Published: October 2019

Objective This article assesses recent trends in tenure length for chairs of academic departments of ophthalmology.

Materials and Methods This is a cross-sectional study of current chairs from 136 institutions. Questionnaires emailed to ophthalmology chairs assessed duration of tenure and demographics of current and previous chairs. Based off of this data, trends in tenure length, turnover rates, and retention rates were determined.

Results From 1998 to 2018, 255 individuals held the position of chair at 95 academic departments of ophthalmology. Mean tenure length was 17.8 years for chairs whose tenure included 2005, and decreased to 15.2 and 10.4 years for chairs whose tenures included 2010 and 2015, respectively. Mean annual turnover began at 5.3% in the first 5 years of the study, increasing to 6.5% in the following 5 years before returning to a baseline of 5.3% in the past 5 years. An average turnover of 5.2% was demonstrated during the entire study period. Five-year retention rates for new chairs averaged at 86.2%. Representation of female chairs rose from values of 2.1 and 3.1% in the beginning of the period to 7.3 and 8.4% in 2015 and 2016, respectively.

Conclusions The average turnover rate for chairs of ophthalmology has remained stable over the past 20 years, with an observed slight decrease in mean tenure length. This stability is welcomed in the wake of predicted turnover within the field of ophthalmology, but continued assessment and preventative policies should be maintained to continue current trends.
Use of an Implant O-Ring Attachment for the Tooth Supported Mandibular Overdenture: A Clinical Report
Authors: Guttal Satyabodh S , Tavargeri Anand K , Nadiger Ramesh K , Thakur Srinath L
Published: October 2019

Retention of a mandibular denture can be achieved by an implant-retained or natural toothretained bar and stud attachment in the anterior segment of the mandible. The same design principles holds true for both implant-retained and tooth-retained methods of anchoring the bar and stud attachment. A simple and cost effective treatment for more complex implant overdenture is the concept of conventional tooth-retained overdentures. When few firm teeth still remain in a compromised dentition, preservation of these teeth for overdentures can improve retention and stability. The authors present a clinical report of a patient treated with a mandibular tooth-borne overdenture with bar and O-ring attachment. A splinted bar supported the prosthesis and an O-ring retained the denture. (Eur J Dent 2011;5:331-336)
Rhabdomyosarcoma of the Oral Cavity: A Case Report
Authors: Miloglu Ozkan , Altas Sare Sipal , Buyukkurt Mustafa Cemil , Erdemci Burak , Altun Oguzhan
Published: October 2019

Rhabdomyosarcoma (RMS), a tumor of skeletal muscle origin, is the most common soft tissue sarcoma encountered in childhood and adolescence. The common sites of occurrence are the head and neck region, genitourinary tract, retroperitonium, and, to a lesser extent, the extremities. In the head and neck region, the most commonly affected sites are the orbit, paranasal sinuses, soft tissues of the cheek, and the neck. RMS is relatively uncommon in the oral cavity, and the involvement of the jaws is extremely rare. Here, we report a case of oral RMS in a 13-year-old child and describe the clinical, radiological, histopathological, and immunohistochemical findings. (Eur J Dent 2011;5:340-343)
Fracture Resistance of Retreated Roots Using Different Retreatment Systems
Authors: Er Kursat , Tasdemir Tamer , Siso Seyda Herguner , Celik Davut , Cora Sabri
Published: October 2019

Objectives: This study was designed to evaluate the fracture resistance of retreated roots using different rotary retreatment systems. Methods: Forty eight freshly extracted human canine teeth with single straight root canals were instrumented sequentially increasing from size 30 to a size 55 using K-files whit a stepback technique. The teeth were randomly divided into three experimental and one control groups of 12 specimens each. The root canals were filled using cold lateral compaction of gutta-percha and AH Plus (Dentsply Detrey, Konstanz, Germany) sealer in experimental groups. Removal of gutta-percha was performed with the following devices and techniques: ProTaper Universal (Dentsply Maillefer, Ballaigues, Switzerland), R-Endo (Micro-Mega, Besançon, France), and Mtwo (Sweden & Martina, Padova, Italy) rotary retreatment systems. Control group specimens were only instrumented, not filled or retreated. The specimens were then mounted in copper rings, were filled with a self-curing polymethylmethacrylate resin, and the force required to cause vertical root fracture was measured using a universal testing device. The force of fracture of the roots was recorded and the results in the various groups were compared. Statistical analysis was accomplished by one-way ANOVA and a post hoc Tukey tests. Results: There were statistically significant differences between the control and experimental groups (P<.05). However, there were no significant differences among the experimental groups. Conclusions: Based on the results, all rotary retreatment techniques used in this in vitro study produced similar root weakness. (Eur J Dent 2011;5:387-392)
Bonding All-Ceramic Restorations with Two Resins Cement Techniques: A Clinical Report of Three-Year Follow-Up
Authors: Anchieta Rodolfo Bruniera , Rocha Eduardo Passos , Almeida Erika Oliveira de , Freitas Junior Amilcar Chagas , Martini Ana Paula
Published: October 2019

Ceramics have been widely used for esthetic and functional improvements. The resin cement is the material of choice for bonding ceramics to dental substrate and it can also dictate the final esthetic appearance and strength of the restoration. The correct use of the wide spectrum of resin luting agents available depends on the dental tooth substrate. This article presents three-year clinical results of a 41 years old female patient B.H.C complaining about her unattractive smile. Two all-ceramic crowns and two laminates veneers were placed in the maxillary incisors and cemented with a self-adhesive resin luting cement and conventional resin luting cement, respectively. After a three-year follow-up, the restorations and cement/teeth interface were clinically perfect with no chipping, fractures or discoloration. Proper use of different resin luting cements shows clinical appropriate behavior after a three-year follow-up. Self-adhesive resin luting cement may be used for cementing all-ceramic crowns with high predictability of success, mainly if there is a large dentin surface available for bonding and no enamel at the finish line. Otherwise, conventional resin luting agent should be used for achieving an adequate bonding strength to enamel. (Eur J Dent 2011;5:478-485)