bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of a Combined Method of Normobaric Hypoxia on the Repeated Sprint Ability Performance of a Nine-Time World Champion Triathlete: A Case Report
Authors: Gonzalez-Custodio Adrian , Crespo Carmen , Timón Rafael , Olcina Guillermo
Published: November 2024

Elite athletes are an under-represented population in scientific studies, and there are no works analysing the influence of hypoxia in elite triathletes. The aim of this study was to analyse the influence of different methods of normobaric hypoxia on repeated sprint ability (RSA) performance. This study was a case study with an elite triathlete who has won nine triathlon world championships. The study used a combination of different methods of normobaric hypoxia. The three methods combined were as follows: live high-train low interspersed; intermittent hypoxic training; and intermittent hypoxic exposure. This study analysed the influence of these methods on RSA performance in variables such as power output, saturation of muscular oxygen, heart rate and ventilatory variables (VO2 and VCO2). The triathlete was measured before the training protocol (PRE), just after (POST-D3) and 21 days after the end of the protocol (POST-D21). This type of protocol has shown that it can lead to an improvement in RSA performance in the number of sprints (PRE vs. POST-D3 vs. POST-D21: 19 vs. 24 vs. 28), power output (PRE 615 W vs. POST-D3 685 W vs. POST-D21 683W) and efficiency of the triathlete. This work may be useful in improving power output and repeated sprint ability for elite triathletes.
The Applicability and Reflection Characteristics of Coal Failure Events for External Monitoring-While-Drilling of Underground Pressure Relief Drilling
Authors: Zhang Wenlong , Ren Jianju , Wang Yongqian , Li Chen , Zhang Yingchao , Teng Shibin
Published: November 2024

Previous research results preliminarily indicated that the Coal Failure Events (CFEs) that occurred during the process of Underground Pressure Relief Drilling (UPRD) represented the phenomenon of coal fracture and energy release. The research results had excellent value for the monitoring and response of pressure relief drilling while drilling, but there were still some special situations that needed to be analyzed and studied in actual on-site testing. So, through on-site testing and data statistical analysis, the study investigated the applicability of the innovative external Monitoring-While-Drilling (MWD) method for UPRD with more coal failure events and made a quantitative statistic of the CFEs and their relationship with abutment pressure to reveal the applicability of the external MWD method and characteristic of CFEs. The results showed that hundreds of CFEs were produced in the UPRD process, which must be removed to ensure the accuracy of the MWD method. Although CFEs bring recognition difficulties, they also provide conditions for studying their own distribution and characteristics. Results showed that more CFEs were produced in the depth of difficult drilling, which indicated that there was a positive correlation between the degree of difficulty in drilling and the number of CFEs. In addition, spectrum analysis showed that the depths with more CFE occurrence were more likely to produce high-frequency events. When the surrounding stress of drilling rocks is high, the occurrence of small fractures with a higher main frequency may become more frequent and consistent; more fractures with similar failure forms would occur, which may have a lower fractal dimension and promote the generation of more failure. The research results were of great significance for the MWD method for UPRD, a quantitative study of CFEs and their generation characteristics during UPRD construction.
Strength- and Moisture-Related Studies of Historical Building Materials: A Case Study from Southern Estonia
Authors: Gineiko Aljona , Kiviste Mihkel
Published: November 2024

Demolition of existing buildings turns building products into waste. The amount of demolition waste is increasing globally. The current case study is an example of fulfilling the EU Waste Framework Directive of reducing demolition waste by reuse of historical materials in their original structures. The aim of this paper is to investigate construction materials from 19th and 20th centuries and their mechanical and physical properties in a case study building from the conservation area of Võru city, South Estonia. Timber structures of the case study building were non-destructively tested on-site using a resistive method. Ceramic brick plinth and basement walls, as well as concrete and granite ceiling, were tested in situ non-destructively (rebound hammer test) for compressive strength estimation. Previously dismantled timber logs, slats and ceramic bricks were tested in the laboratory for compression and bending, respectively. The logs and slats matched the European timber bending strength classes C22 and C40, respectively. The compressive strength of the studied ceramic bricks was comparable to that of newly produced bricks. The non-destructive moisture content of timber structures varied in spring (5–20%) but was steady in the autumn (5–7%) tests. The rebound hammer test overestimated by 1.5…2 times the compressive strength of the studied materials compared to laboratory tests.
Exploring the Role of Smellscape in Enhancing Landscape Perception: A Case Study in the University History Museum
Authors: Liang Qing , Lin Shucan , Wang Linwei , Yang Fanghuan
Published: November 2024

As the cultural importance of universities continues to grow, university museums have become key platforms for promoting university heritage and values. However, enhancing the visitor experience in these museums remains challenging. This study examines the effectiveness of smellscape in enhancing the visitor experience in university history museums, with a focus on how various scents impact visitors’ emotions. Using the Fuzhou University History Museum as a case study, the museum was divided into three distinct zones: the Historical Evolution Zone (HEZ), the Contemporary Development Zone (CDZ), and the Thematic Exhibition Zone (TEZ). Specific scents were selected for each area to evaluate their emotional impact, and data were gathered using electroencephalography (EEG) indicators, emotional questionnaires, and scent pleasure scales. The results indicated that calming scents like sandalwood and agarwood, used in the HEZ, convey a sense of historical depth but may also evoke negative emotions, whereas sage enhances positive feelings. In the CDZ, rosemary and mint significantly improve emotional states, while lemongrass exhibits weaker pleasantness and appears less suited for this area. In the TEZ, scents such as patchouli and orange blossom align well with future-oriented themes, demonstrating high levels of pleasantness and emotional value. Smellwalk interviews further validated the experimental results, revealing notable differences in the emotional impact of smellscape across different exhibit zones. A thoughtful selection of scents can enhance the cultural expression of spaces and effectively regulate visitors’ emotional experiences, strengthening the cultural resonance of museum environments. Future designers may consider incorporating olfactory elements into landscape design.
Analysis of Scattering Mechanisms in SAR Image Simulations of Japanese Wooden Buildings Damaged by Earthquake
Authors: Yu Yang , Takeuchi Wataru
Published: November 2024

The difficulty in identifying collapsed houses and damaged structures in synthetic aperture radar (SAR) images after natural disasters represents a significant challenge in the monitoring of urban structural deformation using SAR. SAR image simulation was conducted on a three-dimensional model of a typical wooden building in Japan to analyze the scattering mechanism of the structure in collapsed and uncollapsed states. Based on the physical properties of the buildings, a correlation was established between the simulated SAR image feature signals and the geometric structures of the buildings. The findings indicate that SAR scattering is more uniform for uncollapsed structures, which is predominantly influenced by their geometry. At low incidence angles, single reflections were the predominant phenomenon, whereas at high incidence angles, multiple reflections became more prevalent. The uncollapsed building’s facade formed a dihedral angle, exhibiting bright lines in the SAR image. Multiple reflections occurred at the edges of the building and floor junctions. These findings follow the theoretical predictions. In the case of the collapsed buildings, multiple reflections occurred with greater frequency, and irregular scattering was observed. Notwithstanding the augmented scattering pathways, some walls nevertheless manifested single reflections. The collapsed structures demonstrated a reduced sensitivity to alterations in the angle of incidence.
Lateral Effects of Jet Grouting on Surrounding Soil and Circular Diaphragm Walls
Authors: Yao Yu , Shi Xuefei , Han Dongdong
Published: November 2024

The installation of high-pressure jet grout piles induces significant lateral soil displacement, which can adversely affect nearby structures, such as diaphragm walls. Based on field tests, this study systematically analyzes the lateral displacement of soil caused by two distinct grouting techniques: the intelligent sensing super jet pile (SJT) technique and the Rodin jet pile (RJP) technique. Experimental results show that the SJT technique induces less disturbance to surrounding soil, with a maximum lateral displacement of approximately 6 mm at the closest inclinometer and an influence range limited to about 4 m. A theoretical model, based on passive pile theory, was developed to predict the lateral deflection of diaphragm walls due to adjacent jet grouting. Using a finite difference algorithm, bending moments on the walls were calculated and compared to measured data, showing a consistent correlation between predictions and observations. These findings are crucial for the design and construction of jet grout piles near sensitive structures, ensuring the safety and reliability of soil improvement practices and underground engineering.
Design Methods of Aluminium Pin-Ended Columns with Topology-Optimised Cross-Sections
Authors: Güler Mehmet Ali , Artac Aykut , Yildirim Bora , Tsavdaridis Konstantinos Daniel
Published: November 2024

This paper presents a numerical study of topology-optimised pin-end aluminium alloy columns using finite element analysis (FEA). The FEA models integrate geometric imperfections and material nonlinearity, and are validated against experimental findings from the existing literature. ABAQUS v.6.15 (release 2020) is used in preparing the FEA models and obtaining the analysis results. Furthermore, modern design methodologies including Eurocode 9, the direct strength method (DSM), and the continuous strength method (CSM) are employed to assess the maximum load capacity of such columns. Parametric investigations encompass diverse parameters such as varied cross-sections, column lengths, and global and local imperfections. By analysing a total of 288 FE models, incorporating 16 column cross-sections across two lengths with nine distinct imperfections, this study compares results with those derived from modern design methodologies. Thus, this research elucidates the behaviour of novel cross-sections and the application of contemporary design techniques in their analysis.
Designing Multi-Family Residences in the Post-COVID-19 Era: Addressing Workspace Privacy Needs
Authors: Moshaver Sam , Ozarisoy Bertug , Altan Hasim , Gosula Shiva Kumar
Published: November 2024

The COVID-19 pandemic profoundly affected every aspect of human life. Among the myriad changes, it catalyzed a significant shift in the way we perceive and use our living spaces. The home, traditionally seen as a refuge from work and external pressures, rapidly became a multifunctional space, doubling as an office, school, gym, and recreation center. Before the pandemic, open-plan living was on the rise, championing multifunctional spaces. However, with the sudden need for remote work, the demand for dedicated home offices or quiet corners became evident. People began to value having a distinct, quiet workspace that would not disturb other members of the household. In this paper, we highlight the importance of incorporating a separate room, distanced from the main private areas of a home, during the early design stages. This approach enhances privacy and subsequently boosts the psychological well-being of the household occupants. The research contributes to building-system integration by demonstrating how architectural configurations and spatial design elements can be optimized to enhance building performance, functionality, and occupant comfort in multi-family residential structures. The aim of this study is to explore the correlations between spatial design quality and occupants’ productivity while working from home. It employs a mixed-methods approach that combines various techniques to provide comprehensive analyses.
In Situ Testing and Finite Element Analysis of a Discontinuous Mortise and Tenon Stone Bridge Under Natural Excitation
Authors: Hu Jiaxing , Wang Shilong , Sun Ming , Zhou Ji
Published: November 2024

To study the dynamic response of multi-span mortise and tenon stone bridges under natural excitation, a bluestone multi-span stone bridge with a main span of 2.56 m in southern China was taken as the research object. Based on the collected pulsating signals of bridge piers and slabs, the natural frequencies and damping ratios of the main span bridge slab and pier were analyzed using the half-power broadband method (HPBM) and random decrement technique (RDT). Modal analysis was conducted using ANSYS, and the results were compared with those obtained from on-site experiments for further performance analysis. The research results of this article indicate that the natural frequency range of the 2.56-m bridge slab identified by measured signals is 48–49 Hz, and the damping ratio range is 33.33–36.61%. The natural frequency of the central pier is 75–76 Hz, and the damping ratio range is 26.39–27.83%. Through finite element modal analysis, the natural frequency of the bridge slab is 54.401 Hz, with an error of 10.5%. The natural frequency of the overall stone bridge is about 82.2 Hz, with an error of about 8.2%. The validated finite element model was subjected to normal water flow impact and erosion simulation. The results indicate that under erosion with fewer particles and lower flow rates, the upstream pier bottom at the center receives the highest relative erosion mass and displacement per unit area. The bridge deck near the main span also experienced relative displacement. Therefore, in the subsequent protection work, special attention should be paid to these components.
Optimizing Care Across the Continuum for Older Adults with Lung Cancer: A Review
Authors: Thompson Leah , Florissi Caterina , Yoon Jaewon , Singh Anupama , Saraf Anurag
Published: November 2024

Older adults with lung cancer experience inferior clinical outcomes compared to their younger counterparts. This review provides the scaffolding to address these disparities by delineating (1) the distinct and varied care needs of older adults with lung malignancies, (2) evidence-based measures for identifying subgroups within this population meriting tailored approaches to care, (3) age-specific considerations for the selection of cancer-directed therapy, and (4) opportunities for future work to enhance clinical outcomes and care delivery.
Comparison of Treatment Outcomes Between First-Line Chemotherapy With or Without Bevacizumab for Advanced Ovarian Clear Cell Carcinoma (Tohoku Gynecologic Cancer Unit: TGCU-RS001A Study)
Authors: Shoji Tadahiro , Takatori Eriko , Nagasawa Takayuki , Kagabu Masahiro , Baba Tsukasa , Shigeto Tatsuhiko , Matsumura Yukiko , Shimizu Dai , Terada Yukihiro , Seino Manabu , Ohta Tsuyoshi , Nagase Satoru , Shigeta Shogo , Tokunaga Hideki , Shimada Muneaki , Kaiho-Sakuma Michiko , Furukawa Shigenori , Soeda Shu , Watanabe Takafumi , Takahashi Fumiaki , Yokoyama Yoshihito
Published: November 2024

Objective: The usefulness of bevacizumab (BEV) as first-line chemotherapy for advanced ovarian clear cell carcinoma (CCC) was retrospectively evaluated at Tohoku Gynecologic Cancer Unit institutions. Patients and Methods: A total of 81 patients (52 patients without BEV and 29 with BEV) with advanced ovarian CCC who received initial platinum-based chemotherapy were enrolled. We selected 26 patients each without and with BEV according to propensity score matching methods, and compared the platinum-resistant recurrence rate, response rate, progression-free survival (PFS), overall survival (OS), and adverse events between the two groups. Results: The objective response rates for the patients with measurable disease in the non-BEV and BEV groups were 60.0% and 95.5%, respectively (p = 0.007). The recurrence of platinum-resistant patients was observed in 50.0% of the non-BEV group and 23.1% of the BEV group (p = 0.117). The median PFS was 12 and 22 months, respectively (p = 0.034), and the median OS was 32 and 47 months, respectively (p = 0.223). In the BEV group, grade 3 hypertension and proteinuria occurred in two patients, and thrombosis and carboplatin hypersensitivity occurred in one patient. Grade 4 gastrointestinal perforation occurred in one patient. Conclusions: First-line chemotherapy with BEV in advanced CCC showed the potential for high response rates and improved PFS.
Camptothecin and Its Derivatives from Traditional Chinese Medicine in Combination with Anticancer Therapy Regimens: A Systematic Review and Meta-Analysis
Authors: Odeniran Paul O. , Madlala Paradise , Mkhwanazi Nompumelelo P. , Soliman Mahmoud E. S.
Published: November 2024

Background/Objectives: Camptothecin (CPT) and its derivatives, irinotecan and topotecan, are integral components of cancer chemotherapy, often used in combination therapies. This meta-analysis evaluates the efficacy of CPT-based combination treatments in cancer patients. Methods: We systematically searched the literature database using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist for articles published between 2000 and 2022. Published studies were retrieved through an electronic search on the Web of Science, PubMed, and Google Scholar databases. A total of 138 studies were downloaded and examined, and 71 eligible studies were selected for meta-analysis after excluding studies that did not meet the inclusion criteria. Results: Ultimately, a total of 71 studies were included in the analysis, comprising non-small cell lung cancer (NSCLC), colorectal cancer (COLRC), oesophageal/gastric cancer (O/GC), and small cell lung cancer (SCLC). For NSCLC, the objective response rate (RR) was 31.8% (95% CI: 27.3–37.1%, p = 0.025), with irinotecan plus cisplatin showing significantly higher efficacy compared to other irinotecan-based combinations. In COLRC, irinotecan and 5-fluorouracil/leucovorin plus bevacizumab demonstrated superior efficacy with a RR of 44% (95% CI: 34–58, p < 0.001) and minimal haematological toxicity. In O/GC, irinotecan-based combinations showed an average RR of 43% (95% CI: 27–70, p < 0.001) and average overall survival (OS) and progression-free survival (PFS) rates of 10.2 and 5.5 months, respectively. For SCLC, irinotecan-based combinations had a higher control response than topotecan-based ones, while the latter exhibited higher rates of stable and progressive disease. The overall RR for SCLC was 45% (95% CI: 34.3–60.2, p < 0.001). Conclusions: The existing evidence underscored the potential of CPT-based combination therapy in various cancers. Among the various combinations discussed in this analysis, irinotecan plus cisplatin demonstrated the highest objective RR in 12 trials focused on NSCLC. This study provides valuable insights into potential treatment strategies for various types of cancer, emphasising the importance of personalised and tailored approaches to maximise efficacy and minimise adverse effects.
Netupitant Inhibits the Proliferation of Breast Cancer Cells by Targeting AGK
Authors: Zhang Zhibo , Liu Yongzhuang , Wu Hai , Yuan Yan , Liu Zhengrui , Sulaiman Muhammad , Yuan Shengtao , Yang Mei
Published: November 2024

Background: Currently, there is a significant lack of effective pharmacological agents for the treatment of breast cancer. Acylglycerol Kinase (AGK), a lipid kinase, has been found to be aberrantly expressed in breast cancer and is closely associated with tumor proliferation, migration, and invasion. However, no clinical anti-tumor drugs specifically targeting this kinase have been developed. Methods: siRNA was utilized to knock down the AGK gene; CCK8 and colony formation assays were employed to evaluate the in vitro proliferative capacity of tumor cells. Molecular dynamics simulations and BIL assays were conducted to analyze drug binding affinity. Annexin V/PI staining was used to assess apoptotic phenomena; subcutaneous xenograft tumor experiments in nude mice were performed to confirm the in vivo anti-tumor efficacy of the drug. Results: Netupitant exhibited stable binding affinity for AGK and interacted with amino acids within the ATP-binding region of the enzyme. The IC50 values for the SK-BR-3 and MDA-MB-231 cell lines were determined as 16.15 ± 4.25 µmol/L and 24.02 ± 4.19 µmol/L, respectively; at a concentration of 2.5 µmol/L, Netupitant effectively inhibited clonogenic capacity in breast cancer cells; furthermore, treatment with 10 µmol/L significantly induced apoptosis in these cells. Doses of 50 mg/kg and 100 mg/kg Netupitant markedly suppressed growth rates of subcutaneous xenograft tumors in nude mice while also promoting apoptotic processes. Both in vivo and in vitro studies indicated that Netupitant could inhibit the activation of the PI3K/AKT/mTOR signaling pathway. Conclusions: By targeting AGK, Netupitant inhibits its kinase activity, which leads to reduced phosphorylation levels of PTEN, thereby suppressing the activation of the PI3K/AKT/mTOR signaling pathway and ultimately resulting in apoptosis in breast cancer cells.
Evaluation of Subclinical Cancer Therapy-Related Cardiac Dysfunction in Patients Undergoing Hematopoietic Stem Cell Transplantation: An Echocardiography Study
Authors: Vaitiekiene Audrone , Kulboke Migle , Bieseviciene Monika , Kaunaite Austeja , Markeviciute Auste , Bartnykaite Agne , Kireilis Benas , Rinkuniene Diana , Jankauskas Antanas , Gaidamavicius Ignas , Gerbutavicius Rolandas , Vaitiekus Domas , Sakalyte Gintare , Vaskelyte Jolanta Justina
Published: November 2024

Background: Hematopoietic stem cell transplantation (HSCT) is a potentially curative procedure that is used in various hematological malignancies. However, among an increasing number of HSCT, the amount of cancer therapy-related cardiac dysfunction (CTRCD) is increasing as well. This study aimed to determine the prevalence of subclinical CTRCD in HSCT patients 12 months after HSCT and to assess the impact of clinical factors on the development of CTRCD. Material and Methods: We included 55 patients who underwent autologous or allogeneic HSCT. The patients were assessed using an echocardiography method before and 12 months after a HSCT procedure. Results: Our study revealed that during the 12-month follow-up period, asymptomatic CTRCD was observed in 15 patients (27.3%), 6 experienced moderate CTRCD, and 9 experienced mild CTRCD. Patients with previous use of anthracyclines tended to have CTRCD more often: nine patients (60%) in the CTRCD group and nine patients (22.5%) in non-CTRCD group. Patients who received the BEAM regimen for conditioning also experienced CTRCD more often: five patients (33.3%) in CTRCD group vs. two patients (5%) in the non-CTRCD group. Conclusions: Our study showed that asymptomatic CTRCD was found in 27.3% of the patients 12 months after HSCT. The BEAM chemotherapy conditioning protocol following prior anthracycline use were identified as factors contributing to the development of CTRCD.
Cu-Based Praseodymium-Modified γ-Al2O3 Oxygen Carrier for Chemical Looping Combustion Process Optimization
Authors: Qasim Muhammad , Osman Noridah Binti , Ayoub Muhammad , Aqsha Aqsha
Published: November 2024

Chemical looping combustion (CLC) emerges as a cost-effective CO2 capture technology, demonstrating high competitiveness for both industrial and energy applications. This study explores the synthesis of a Cu-based, praseodymium (Pr)-modified gamma-alumina-supported (20CuPA) oxygen carrier (OC) through the wet impregnation method and investigates its performance in CLC. The characteristics of the synthesized OC were investigated using field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, temperature-programmed reduction analysis, and X-ray diffraction analysis. The CLC of methane gas was performed in a thermogravimetric analyzer (TA-Q50). The oxygen transport capacity (OTC) of the 20CuPA-based OC was investigated for 10 redox cycles. The impact of temperature and time as process variables in determining the OTC of OCs was studied. The TGA results indicated that the most important factor influencing the optimization of the OTC of OCs was time. In comparison to time, temperature had less of an impact on the OTC of 20CuPA-OC. The maximum OTC of 20CuPA-OC, which was 0.0546 mg of O2/mg of OC, was reached using optimized process variables, including a temperature of 800 °C and a time of 3 min.
Cold Plasma Techniques for Sustainable Material Synthesis and Climate Change Mitigation: A Review
Authors: Joshi Nitesh , Loganathan Sivachandiran
Published: November 2024

In recent years, the emission of greenhouse gases (GHGs) has increased significantly, contributing to global warming. Among these GHGs, CH4, CO2, and CO are particularly potent contributors. Remediation techniques primarily rely on materials capable of capturing, storing, and converting these gases. Catalytic processes, particularly heterogeneous catalysis, are essential to chemical and petrochemical industries as well as environmental remediation. Due to the growing demand for catalysts, efforts are being made to reduce energy consumption and make technologies more environmentally friendly. Green chemistry emphasizes minimizing the use of hazardous reactants and harmful solvents in chemical processes. Achieving these principles should be paired with processes that reduce time and costs in catalyst preparation while improving their efficiency. Non-thermal plasma (NTP) has been widely used for the preparation of supported metal catalysts. NTP has attracted significant attention for its ability to improve the physicochemical properties of catalysts, enhancing process efficiency through low-temperature operation and shorter processing times. NTP has been applied to various catalyst synthesis techniques, including reduction, oxidation, metal oxide doping, surface etching, coating, alloy formation, surface treatment, and surface cleaning. Plasma-prepared transition-metal catalysts offer advantages over conventionally prepared catalysts due to their unique material properties. These properties enhance catalytic activity by lowering the activation energy barrier, improving stability, and increasing conversion and selectivity compared to untreated samples. This review demonstrates how plasma activation modifies material properties and, based on extensive literature, illustrates its potential to combat climate change by converting CO2, CH4, CO, and other gases, showcasing the benefits of plasma-treated materials and catalysts. A succinct introduction to this review outlines the advantages of plasma-based synthesis and modification over traditional synthesis techniques. The introduction also highlights the various types of plasma and their physical characteristics across different factors. Additionally, this review addresses methods by which materials are synthesized and modified using plasma. The latter section of this review discusses the use of non-thermal plasma for greenhouse gas mitigation, covering applications such as the dry reforming of CH4, CO and CH4 oxidation, CO2 reduction, and other uses of plasma-modified catalysts.
Production of Aviation Fuel-Range Hydrocarbons Through Catalytic Co-Pyrolysis of Polystyrene and Southern Pine
Authors: Kemp Ayden , Rahman Tawsif , Jahromi Hossein , Adhikari Sushil
Published: November 2024

Sustainable aviation fuels (SAFs), produced from waste and renewable sources, are a promising means for reducing net greenhouse gas emissions from air travel while still maintaining the quality of air transportation expected. In this work, the catalytic co-pyrolysis of polystyrene and pine with red mud (bauxite residue) and ZSM-5 catalysts at temperatures of 450 °C, 500 °C, and 550 °C was investigated as a method for producing aromatic hydrocarbons with carbon numbers ranging from 7 to 17 for use as additives to blend with SAF produced through other methods to add the required quantity of aromatic molecules to these blends. The maximum yield of kerosene-range aromatic hydrocarbons was 620 mg per gram of feedstock (62% of feedstock was converted to kerosene-range hydrocarbons) obtained at 550 °C in the presence of ZSM-5. Additionally, it was noted that a positive synergy exists between pine and polystyrene feedstocks during co-pyrolysis that cracks solid and liquid products into gaseous products similarly to that of a catalyst. The co-pyrolysis of pine and polystyrene without a catalyst produced on average 17% or 36.3 mg more kerosene-range hydrocarbons than predicted, with a maximum yield of 266 mg of C7–C17 aromatic hydrocarbons per gram of feedstock (26.6% conversion of initial feedstock) obtained at 550 °C.
Photocatalytic Reactions over TiO2-Based Interfacial Charge Transfer Complexes
Authors: Lazić Vesna , Nedeljković Jovan M.
Published: November 2024

The present review is related to the novel approach for improvement of the optical properties of wide bandgap metal oxides, in particular TiO2, based on the formation of the inorganic–organic hybrids that display absorption in the visible spectral range due to the formation of interfacial charge transfer (ICT) complexes. We outlined the property requirements of TiO2-based ICT complexes for efficient photo-induced catalytic reactions, emphasizing the simplicity of the synthetic procedure, the possibility of the fine-tuning of the optical properties supported by the density functional theory (DFT) calculations, and the formation of a covalent linkage between the inorganic and organic components of hybrids, i.e., the nature of the interface. In addition, this study provides a comprehensive insight into the potential applications of TiO2-based ICT complexes in photo-driven catalytic reactions (water splitting and degradation of organic molecules), including the identification of the reactive species that participate in photocatalytic reactions by the spin-trapping electron paramagnetic resonance (EPR) technique. Considering the practically limitless number of combinations between the inorganic and organic components capable of forming oxide-based ICT complexes and with the knowledge that this research area is unexplored, we are confident it is worth studying, and we emphasized some further perspectives.
Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15
Authors: Sigal Emiliya , Shavit Maya , Atzmon Yuval , Aslih Nardin , Bilgory Asaf , Estrada Daniella , Michaeli Mediea , Rotfarb Nechama , Shibli Abu-Raya Yasmin , Meisel-Sharon Shilhav , Shalom-Paz Einat
Published: November 2024

This prospective, case-control study evaluated the impact of obesity on oocyte quality based on mtDNA expression in cumulus cells (CC), and on bone morphogenetic protein 15 (BMP-15) and heparan sulfate proteoglycan 2 (HSPG2) in follicular fluid (FF). It included women 18 to <40 years of age, divided according to BMI < 24.9 (Group 1, n = 28) and BMI > 25 (Group 2, n = 22). Demographics, treatment, and pregnancy outcomes were compared. The mtDNA in CC, BMP-15, HSPG2, the lipid profile, the hormonal profile, and C-reactive protein were evaluated in FF and in blood samples. The BMP-15 levels in FF and the mitochondrial DNA in CC were higher in Group 1 (38.8 ± 32.5 vs. 14.3 ± 10.8 ng/mL; p = 0.001 and 1.10 ± 0.3 vs. 0.87 ± 0.18-fold change; p = 0.016, respectively) than in Group 2. High-density lipoprotein levels in blood and FF were higher in Group 1 (62 ± 18 vs. 50 ± 12 mg/dL; p = 0.015 and 34 ± 26 vs. 20.9 ± 7.2 mg/dL; p = 0.05, respectively). Group 2 had higher blood C-reactive protein (7.1 ± 5.4 vs. 3.4 ± 4.3 mg/L; p = 0.015), FF (5.2 ± 3.8 vs. 1.5 ± 1.6 mg/L; p = 0.002) and low-density lipoprotein levels (91 ± 27 vs. 71 ± 22 mg/dL; p = 0.008) vs. Group 1. Group 1 demonstrated a trend toward a better clinical pregnancy rate (47.8% vs. 28.6%: p = 0.31) and frozen embryo transfer rate (69.2% vs. 53.8; p = 0.69). Higher BMI resulted in lower BMP-15 levels and reduced mtDNA expression, which reflect decreased oocyte quality in overweight women.
Evolution of CO2 Uptake Degree of Ordinary Portland Cement During Accelerated Aqueous Mineralisation
Authors: Ferrara Giuseppe , Humbert Pedro , Garufi Davide , Palmero Paola
Published: November 2024

The utilisation of carbonation treatments to produce building materials is emerging as a valuable strategy to reduce CO2 emissions in the construction sector. It is of great importance to regulate the degree of carbonation when the mineralisation process is combined with hydration, as a high CO2 uptake may impede the development of adequate strength. A significant number of studies focus on attaining the maximum carbonation degree, with minimal attention paid to the examination of the evolution of CO2 uptake over the initial stages of the process. In this context, the present study aims to investigate the evolution of CO2 uptake over time during carbonation. Ordinary Portland Cement (OPC) is employed as material, with aqueous carbonation selected as the mineralisation process. This investigation encompasses a range of carbonation durations, spanning from 5 to 40 min. The analysis of the evolution of the mineral composition with time demonstrated that the rate of the carbonation reaction accelerates in the initial minutes, resulting in the conversion of all the portlandite produced during the hydration process in the initial 10 min. Quantitative analysis of the carbonation degree indicated that the CO2 uptake at 40 min is equal to 19.1%, which is estimated to be approximately 70% of the maximum achievable value. By contributing to the understanding of the early carbonation mechanisms in aqueous conditions of OPC, this study provides valuable support for further investigation focused on the use of cement mineralisation processes to produce building materials.
The Diagnosis and Management of Infraoccluded Deciduous Molars: A Systematic Review
Authors: Dipalma Gianna , Inchingolo Alessio Danilo , Memè Lucia , Casamassima Lucia , Carone Claudio , Malcangi Giuseppina , Inchingolo Francesco , Palermo Andrea , Inchingolo Angelo Michele
Published: November 2024

The infraocclusion (IO) of primary molars, often seen in retained deciduous teeth, is a common condition that presents significant challenges for pediatric oral health. It occurs when primary molars are positioned below the occlusal plane due to the absence of permanent successors, leading to complications such as misaligned teeth, impaired chewing, and long-term dental health issues. Objectives: This study examines IO prevalence, diagnosis, and treatment approaches. Methods: A systematic review following PRISMA guidelines was conducted, searching PubMed, Web of Science, and Scopus for articles from the last 15 years. Nine articles were included for qualitative analysis. Results: IO was associated with several complications, including root resorption, altered eruption of adjacent teeth, and space loss within the dental arch. Clinical and radiographic evaluations are key to early detection. Severe cases often require invasive treatments, such as tooth extraction and space maintenance, while mild cases could be monitored. Conclusions: IO is prevalent in pediatric dentistry and can lead to significant dental issues if untreated. Early detection and intervention are crucial for preventing complications like tooth misalignment and impacted premolars. Tailored treatment strategies based on severity, along with increased awareness among dental practitioners, are essential to improve long-term outcomes for affected children.
An Actual Insight into the Pathogenic Pathways of Ankylosing Spondylitis
Authors: Păsăran Emilia-Daniela , Diaconu Andreea Elena , Oancea Corina , Bălănescu Andra-Rodica , Aurelian Sorina Maria , Homentcovschi Corina
Published: November 2024

Spondyloarthritis refers to a broad group of conditions that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic arthritis associated with Crohn’s disease or ulcerative colitis. They have been classified by the ASAS group (ASsessment in Ankylosing Spondylitis) into axial spondyloarthritis and peripheral spondyloarthritis. Common features include the absence of autoantibodies, genetic predisposition, and clinical aspects such as axial joint involvement, peripheral manifestations, and extra-articular involvement. However, the pathogenic mechanisms remain complex and incompletely elucidated, despite the fact that the specialized literature has described several pathways that act in synergy: genetic predisposition, environmental factors (infections and mechanical stress), or innate and acquired immune mechanisms. Finally, an inflammatory response is triggered by the recruitment of a large number of inflammatory cells and the release of innate cytokines in the affected areas: joints or periarticular or extraarticular tissues. The current article aims to update and systematize the knowledge accumulated so far on this topic, focusing on the mechanisms that have been involved in the onset, progression, and severity of ankylosing spondylitis.
Enhancing Outcomes and Efficiency in Large Epidermal Cyst Management: Quality Improvement Approach in Primary Care
Authors: Jerjes Waseem , Ramkumar Pratik , Yaqub Yousuf
Published: November 2024

Background: Epidermal cysts are common benign lesions encountered in primary care, especially in minor surgery clinics. The management of large epidermal cysts (>5 cm in diameter) poses significant challenges, including surgical intervention requirements, potential for complications, and impacts on patient care and clinic workflow. The prevalence of these cysts underlines the need for optimised management strategies that are essential for enhancing patient outcomes and clinic efficiency. This quality improvement initiative sought to better manage large epidermal cysts in primary care settings. Patients and methods: The initiative utilised the Plan-Do-Study-Act (PDSA) cycle over three distinct phases, with an emphasis on improving surgical techniques and postoperative care, optimising clinic workflow, and enhancing patient education and involvement. Over the course of this eighteen-month study, 100 patients who required surgical excision of large epidermal cysts were included. The interventions focused on standardising surgical protocols, implementing a new scheduling system, and developing comprehensive educational materials for patients. Results: The programme contributed to major efficiency gains for surgeries: the average operative time was reduced from 45 min to 30. The postoperative complication rate decreased dramatically while patient and clinician satisfaction went up, as did clinic throughput. With patient education enhancements, follow-up adherence rose to 92% while the postoperative complication rate declined from 18% to 9% with the overall approach to patient engagement. Conclusions: The successful application of the PDSA cycles in this work demonstrates that quality improvement methodologies have a potential role in optimising management for large epidermal cysts in primary care settings. Developed interventions can therefore be put into routine care that will indeed improve patient outcome, clinician experience, and operational efficiency in minor surgery clinics.
Impact of Body Mass Index on the Outcomes of Cryoballoon Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation
Authors: Papathanasiou Konstantinos A. , Vrachatis Dimitrios A. , Kossyvakis Charalampos , Giotaki Sotiria G. , Deftereos Gerasimos , Kousta Maria , Anagnostopoulos Ioannis , Avramides Dimitrios , Giannopoulos George , Lambadiari Vaia , Siasos Gerasimos , Deftereos Spyridon
Published: November 2024

Background: Atrial fibrillation (AF) is prevalent among obese patients, and cryoballoon ablation (CBA) is an effective strategy for the rhythm control of AF. The impact of body mass index (BMI) on the clinical outcomes of CBA for AF is not fully explored. Methods: 85 consecutive patients with paroxysmal AF were enrolled and were categorized into three groups as per their BMI: normal weight (BMI 18.5–25 kg/m2), overweight (BMI 25–30 kg/m2), and obese patients (BMI > 30 kg/m2). The primary study endpoint was a late (12 month) recurrence of AF. Early recurrence of AF, symptom improvement, and procedural outcomes were some key secondary outcomes. Results: 20 patients had normal weight, 35 were overweight, and 30 were obese. Obese patients featured a higher prevalence of diabetes mellitus, heavier exposure to smoking, and worse baseline symptoms (as assessed through EHRA class at admission and 12 months before CBA) compared to overweight and normal weight patients. Both late and early (<3 months) AF recurrence rates were comparable across the three groups. Of note, obese patients showed greater improvement in their symptoms post-CBA, defined as improvement by at least one EHRA class, compared to normal weight patients; this might be explained by improved diastolic function. Total procedure time and dose area product were significantly increased in obese patients. The multivariate logistic regression analysis indicated that early AF recurrence and the duration of hypertension are independent predictors of late AF recurrence. Conclusion: CBA is effective in overweight and obese patients with paroxysmal AF. Procedure time and radiation exposure are increased in obese patients undergoing CBA.
Micro-Scale Fracture Characteristics of Emulsified Asphalt Cold Recycled Mixture Based on Discrete Element Method
Authors: Yang Yanhai , Chen Yumeng , Li Baichuan , Yang Ye
Published: November 2024

Asphalt pavement often experiences structural failure due to repeated vehicle loading. The discrete element method (DEM) model was established based on the semicircle bending test (SCB) to investigate the fracture damage mechanism of emulsified asphalt cold recycled mixture (CRME) under loading. The micro-mechanical parameters of CRME were determined through a reliable validation process using the uniaxial compression static creep test. The microscopic fracture characteristics of CRME were investigated through the load-displacement curve, stress distribution, and force chain distribution. The fracture energy was used as the evaluation index to analyze the influence of prefabricated notch length and aggregate gradation on the fracture performance of CRME. The results indicate that the emulsified asphalt mortar-aggregate interface was the critical weak position of the mixture fracture; the failure of the tension chain was the main destructional form of the SCB test. The development of cracks affected the stress concentration phenomenon and stress concentration level of the mixture. Fine-grained mixture exhibited crack resistance. The number and length of cracks were affected by gradation. As the prefabricated notch length increased, the influence gradually diminished. The research results could provide theoretical and data support for the design of CRME.
Unveiling Frequency-Dependent Electromechanical Dynamics in Ferroelectric BaTiO3 Nanofilm with a Core-Shell Structure
Authors: Zhang Mingran , Ma Rui , Zhou Jianqiang , Zhang Yuanxiang , Wang Jie , Weng Shengbin
Published: November 2024

Diverse domain patterns significantly influence the nonlinear electromechanical behaviors of ferroelectric nanomaterials, with polarization switching under strong electric fields being inherently a frequency-dependent phenomenon. Nevertheless, research in this area remains limited. In this study, we present a phase-field investigation of frequency-dependent electromechanical dynamics of a polycrystalline BaTiO3 nanofilm with a core-shell structure, subjected to applied frequencies ranging from 1 to 80 kHz. Our findings elucidate the microstructural mechanisms underlying the electromechanical behaviors observed in these materials. The effect of the grain size and the strains effect are also taken into account. Hysteresis and butterfly loops exhibit a marked change in shape as the frequency changes. We discuss the underlying domain-switching dynamics as a basis for evaluating such frequency-dependent properties. In addition, we examine the scaling behaviors of the dynamic hysteresis and the influence of grain boundaries on the domain structure. We can also observe from hysteresis loops that the remnant polarization and coercive field significantly diminish when grain sizes decrease from 60 to 5 nm. A smaller grain size of the nanofilm yields a larger percentage of the dielectric grain boundary, which “dilutes” the overall ferroelectricity of the film. A vortex domain structure is more likely to form at low frequency and a small grain size.
Comparison of Preprocessing Method Impact on the Detection of Soldering Splashes Using Different YOLOv8 Versions
Authors: Klco Peter , Koniar Dusan , Hargas Libor , Paskala Marek
Published: November 2024

Quality inspection of electronic boards during the manufacturing process is a crucial step, especially in the case of specific and expensive power electronic modules. Soldering splash occurrence decreases the reliability and electric properties of final products. This paper aims to compare different YOLOv8 models (small, medium, and large) with the combination of basic image preprocessing techniques to achieve the best possible performance of the designed algorithm. As preprocessing methods, contrast-limited adaptive histogram equalization (CLAHE) and image color channel manipulation are used. The results show that a suitable combination of the YOLOv8 model and preprocessing methods leads to an increase in the recall parameter. In our inspection task, recall can be considered the most important metric. The results are supported by a standard two-way ANOVA test.
Power Quality Analysis of a Microgrid-Based on Renewable Energy Sources: A Simulation-Based Approach
Authors: Hernández-Mayoral Emmanuel , Jiménez-Román Christian R. , Enriquez-Santiago Jesús A. , López-López Andrés , González-Domínguez Roberto A. , Ramírez-Torres Javier A. , Rodríguez-Romero Juan D. , Jaramillo O. A.
Published: November 2024

At present, microgrids (μGs) are a focal point in both academia and industry due to their capability to sustain operations that are stable, resilient, reliable, and of high power quality. Power converters (PCs), a vital component in μGs, enable the decentralization of power generation. However, this decentralization introduces challenges related to power quality. This paper introduces a μG model, based on the IEEE 14-bus distribution system, with the objective of investigating power quality when the μG is operating in conjunction with the conventional power grid. The μG model was developed using MATLAB-Simulink®, a tool specialized for electrical engineering simulations. The results obtained undergo thorough analysis and are compared with the compatibility levels set by the IEEE-519 standard. This method enables a precise evaluation of the μGs’ capacity to maintain acceptable power quality levels while interconnected with the conventional power grid. In conclusion, this study contributes significantly to the field of μGs by providing a detailed and quantitative assessment of power quality. This will assist in the design and optimization of μGs for effective implementation in real-world electric power systems.