bluuebunny/crossref_metadata_2025 huggingface dataset:
Bærekraftig utvikling: Hva er poenget?
Authors: Pilskog Ingjald , Heggen Marianne Presthus
Published: July 2023

Education for sustainability builds on more than thirty years of experience in utilizing education to guide us to a better future, a future with a good life for all. In 1987, the World Commission on Environment and Development defined sustainable development as “development that meets the needs of the present without compromising the ability of future generations to meet their own needs” (Brundtland et al., 1987b, p. 41). We have interviewed six persons on their views of the concept “sustainable development,” opportunities and challenges they associate with the concept, and how education relates to them. Two of the informants represent the younger generation, two work with sustainability and environment in higher education, and the remaining two have been working with sustainability nationally and internationally for decades.

There is a consensus in international policy to use the concept of sustainable development as broadly as possible worldwide. To achieve an internationally united understanding between differing interests, the concept has gradually been expanded to include more perspectives. Such expansion may dilute the concept’s concrete content and weaken it as a result.

The immediate need for action to meet the challenges of the environmental and climate crises influences our informants’ view of the concept of sustainable development. They see sustainable development as a combination of interlinked and equally important ecological, economic, and social/cultural aspects. They emphasize the good intentions of the concept, but also underline its political and anthropocentric origin as a challenge to achieve the ambitions of the World Commission. We finalize the chapter by looking at how these perspectives influence education for sustainability.
Samisk tradisjonell kunnskap og utdanning for bærekraftig utvikling
Authors: Kvivesen Mona
Published: July 2023

Students should learn about the Sami people’s traditional knowledge and approach to nature in science education. Science teachers, therefore, must become proficient in Sami culture and traditions. Sami traditional practitioners have expertise, and it is important to bring out their voices. In this case study, six reindeer owners are interviewed, and the results show that the siida welcomes student participation in reindeer herding as a means of enabling students to learn about Sami culture and language. Sami traditional knowledge is strongly linked to nature and can help to strengthen students’ connection to nature. Strong connections to natureincrease environmental awareness and can contribute to students making more sustainable choices. Learning about Sami traditional knowledge together with Sami reindeer herders in nature as a learning arena embraces several elements in education for sustainable development and is a context that lends itself well to socio-scientific issues as education for sustainable development.
Implementasi Teknologi pada Aspek Pakan dan Pemasaran di Kelompok Usaha Ransum Pakan Ternak di Kabupaten Padang Pariaman
Authors: Ediset Ediset , Adrizal Adrizal , Arlina Firda , Ratni Eli
Published: July 2023

The community engagement team of the Animal Science Faculty of Andalas University conducted community services in the Animal Feed Ration Business group in Jorong Batang Sarik, Nagari Katapiang, Batang Anai District, Padang Pariaman Regency. The problems in the target group were 1) the business group still needs to get a permit to do business, and 2) it still needs to gain skills in processing feed for cattle based on agricultural waste. The activity aimed to assist business groups in obtaining Business Permit Numbers (BPN) and transferring agricultural waste-based feed technology for beef cattle. The transfer of knowledge and technology in service activities was carried out by mentoring, demonstration, and training methods regularly and continuously. The action resulted that the target group having a business permit in the form of BPN and the business group having knowledge and skills in producing feed for beef cattle in the form of Complete Ration Silage (CRS) based on corn straw.
Pencegahan Stunting melalui Komunikasi Antar Pribadi di Kelurahan Mata Air, Kecamatan Padang Selatan, Kota Padang
Authors: Iqbal Wira , Annisa Dini Nur , Gymnasdian Dyki , Putri Hana Salsabila , Wizi Husnaa Haniifah , Fakhraihansyah Muhammad
Published: July 2023

Stunting or stunted children is a disorder of growth and development due to chronic malnutrition and repeated infections, characterized by their height being below the standards of the Ministry of Health. The stunting rate in Mata Air Village, South Padang District, is also reasonably high. Based on data obtained in October 2022, the number of stunting cases in Mata Air Village is 64 children. It was due to the lack of knowledge of pregnant women about stunting and the low economy of the community in the village. This activity aimed to practical the Interpersonal Communication approach in increasing the knowledge of pregnant women about stunting. The methods used were group discussion and Emotional Demonstration (Emo-Demo) with the application of Interpersonal Communication. The results showed an increase in knowledge from pregnant women. It proved that the Interpersonal Communication approach was quite effective in increasing the knowledge of pregnant women about stunting. The activity received a positive response from the people of Mata Air Village so that it could be carried out sustainably. Therefore, the Interpersonal Communication approach can increase mothers' knowledge about stunting and help prevent stunting in Mata Air Village.
Pengembangan Strategi Promosi Madu Galo-galo UMKM Usaha Bukik Nabu (UBUNA)
Authors: Herwina Henny , Jasmi Jasmi , Ratni Eli , Wellyalina Wellyalina , Fatimah Elni , Fathiyah Nadira Nurul , Sari Maya , Alamsjah Feskaharni , Santoso Putra
Published: July 2023

Stingless bee cultivation in Indonesia, one of which is in West Sumatra, has the potential as an effort to improve the community's economy. Stingless bees, commonly called Galo-galo, can produce honey, propolis, and bee pollen, which have many benefits and produce high selling power. The community service activity accompanying the Bukik Nabu Business (UBUNA) aimed to develop the Galo-galo cultivation business in the Limau Manis village. This village has optimum natural conditions to cultivate stingless bees due to the availability of feed plant surroundings. The method used directly assisted the development of Micro, Small and Medium Enterprises of UBUNA. It started by adding the number of colonies to the community, harvesting independently on the type of Heterotrigona itama and Geniotrigona thoracica, upscaling branding, making product labels, product promotions, legality, and participating in collaborative events and festivals.
Identification of Unknown Inverted Singlet-Triplet Cores by High--Throughput Virtual Screening
Authors: Omar Omer , Xie Xiaoyiu , Troisi Alessandro , Padula Daniele
Published: July 2023

Molecules where the energy of the lowest excited singlet state is found below the energy of the lowest triplet state (inverted singlet-triplet molecules) are extremely rare. It is particularly challenging to discover new ones through virtual screening because the required wavefunction-based methods are expensive and unsuitable for high-throughput calculations. Here, we devised a virtual screening approach where the molecules to be considered with advanced methods are pre-selected with increasingly more sophisticated filters that include the evaluation of the HOMO-LUMO exchange integral and approximate CASSCF calculations. A final set of 7 candidates (0.05\% of the initial 15000) were verified to possess inversion between singlet and triplet states with state-of-the-art multireference methods (MS--CASPT2). One of them is deemed of particular interest because it is unrelated to other proposals made in the literature.
Quality of purula (rice seasoning for anemia from soy protein hydrolysate and seaweed) during pilot plant scale development using drum drying process
Authors: Kahfi J. , Laily N. , Pangestu A. , Muhammaludin  , Rachman D.
Published: July 2023

Purula is a new rice seasoning product made from soy protein hydrolysate and seaweed. It contains low molecular weight (<20 kDa) biopeptide from soybean that can enhance iron absorption and fortified with vitamin and mineral to prevent anemia. This research aimed to monitor the quality of purula and its main ingredient during pilot plant scale process. The two main ingredients of purula are soy protein hydrolysate flour and seaweed slurry. Steam flash explosion and enzymatic hydrolysis treatment were applied to the soybean, followed by drum drying to produce soy protein hydrolysate flour. Brown and green algae were blanched and grinded to make seaweed slurry. Then, they were mixed with flour mix, drum dried, and added with vitamin and mineral to produce purula. Proximate, microbiological, and heavy chemical analysis were conducted on samples taken during stages of purula processing. Moisture content and thickness of Purula flakes were examined during pilot plant process. Molecular weight of protein analysis was also conducted on raw soybean, soy protein hydrolysate, and purula. Microbiological and chemical quality of soy protein hydrolysate flour, seaweed slurry, and purula conform with the food safety requirement. This indicates that Purula is safe for human consumption. Purula flakes produced by drum drying process also share consistent results of moisture content and thickness of Purula flake within 5 days of production. Low molecular weight of protein (<20 kDa) was produced on soy protein hydrolysate and still intact on purula finished product. This study concluded that purula is able to be properly produced on pilot plant scale.
Hamilləlik müddətində kəskin koronavirus-19 infeksiyası olan qadınlarda ciftin və dölyanı mayenin exoqrafik xüsusiyyətləri
Authors: K.G. Guliyeva  , E.M. Aliyeva  , S.S. Sultanova  , Z.S. Muradovich
Published: July 2023

Problemin aktuallığı. Hestasiya müddətində kəskin-respirator virus infeksiyası hamiləliyin gedişatına, embriona, dölə, ciftin formalaşmasına təsir edən amildir. Müəyyən edilmişdir ki, kəskin respirator virus infeksiyasında düşüklərin rastgəlmə tezliyi20-25%, vaxtından qabaq doğuşların rastgəlmə tezliyi - 16,5%, fetoplasentar çatmamazlıq 15,2%-də, dölün bətndaxili inkişaf ləngiməsi 6,7%-də qeyd olunur [1,2].2019-cü ildə kəskin respirator sindromla (SARS- CoV-2) müşahidə edilən koronavirus infeksiyasının bu ilə qədər epidemiyası qeydə alınırdı.
Waste & Design - Systematic Review
Authors:   UFSC, Eschberger Luisa , Peixoto Piettro ,   UFSC, da Rosa Matheus ,   UFSC, Pereira Manoela de ,   UFSC, Ferroli Paulo Cesar Machado ,   UFSC
Published: July 2023

Abstract
Complex geometries in sustainability-oriented architectural works: an integrative approach to architecture teaching
Authors:   UFPel - UNIVERSIDADE FEDERAL DE PELOTAS, Pires Janice de Freitas , Borda Adriane ,   UFPel - UNIVERSIDADE FEDERAL DE PELOTAS, Oliveira Brunna Pereira de ,   UFPel - UNIVERSIDADE FEDERAL DE PELOTAS, Paixão Letícia Pereira ,   UFPel - UNIVERSIDADE FEDERAL DE PELOTAS
Published: July 2023

This article presents the results so far of a research project that brings together the fields of teaching graphic representation and architectural design. The project employs an integrative approach for training in representation, aligned with the concern regarding the functionality of buildings in the face of environmental issues, based on the study of complex geometries that are adopted in reference works. Based on the structured notion of knowledge (techniques, technologies and theories), by Yves Chevallard, analysis activities are developed for works conceived with such geometries together with the discourses of their architects, aiming to understand the relationships they have with the aspects of sustainability. The results refer to the explanation of this knowledge in theoretical and technological terms, to support representation activities, especially with parametric modeling techniques, to be inserted in architecture training.
Social Design - Playful stacking toy for hospitalized children.
Authors:   UFSC, Manoli Pietra Lazzarini , Faria Sthefany Munhoz de ,   UFSC, Pazmino Ana Veronica ,   UFSC
Published: July 2023

In the last 12 years, the number of child hospitalizations registered in Brazil has exceeded 2.6 million, for this reason, a space where they can have fun and relax in this vulnerable moment becomes essential, in view of this, the law stipulates that all hospitals with pediatric care receive a toy library in their environment. Toy libraries are spaces suitable for children to interact with toys, games, activities or with other children, so it is necessary to have a large number of toys, covering all age groups, to guarantee the fun of any individual.
Effectiveness of Problem Based Learning Device Development to Improve Generic Science Skills
Authors: Devi Via Monica , Susilawati Susilawati , Gunada I Wayan
Published: July 2023

This development research aims to develop an effective problem-based physics learning device model to improve students' generic science skills. The type of research used is Research and Development (R&D) using a 4D model. This 4D model consists of four stages, namely Define, Design, Develop and Disseminate. The effectiveness of the learning device was obtained based on the analysis of the observation sheet on the implementation of the lesson plans from three observers was then determined using the calculation of the Interjudge Agreement (IJA) and the N-Gain test. Based on the results of the research that has been carried out, the results of the IJA calculation analysis show that the implementation of learning is above 75% with the N-Gain test results of 0.54 are in the medium category, while the average value for the pretest value is 36.91 and the average posttest value 68.75. So it can be said that the problem based model of physics learning tools used is effective in improving the generic science skills of students
Multidimensional Science Education on Performance Assessment Comprehensively with Collaborative Project Learning Based Model: Philosophy Perspective
Authors: Sudirman Sudirman , Sarjan Muhammad , Rokhmat Joni , Hamidi Hamidi , Fauzi Iswari
Published: July 2023

Competency-based learning requires an assessment instrument capable of comprehensively measuring learning objectives in the cognitive, psychomotor and affective domains. Therefore, an alternative assessment model based on performance is needed. The purpose of writing this article was to find out whether it is possible to comprehensively assess performance based on collaborative project learning in multidimensional science education from a philosophical perspective through literature study. Performance appraisal is a continuous assessment process through the process of collecting various activity-based information as an object of assessment in various ways and tools. Based on the results and discussion of the literature review, performance assessment is a continuous assessment process using various strategies and methods (multi-methods) where in this article the author combined collaborative project-based learning methods. Project based learning provides opportunities for students to explore content and learning experiences using various ways that are meaningful to themselves and to conduct experiments collaboratively by combining various interrelated subjects. Exploration of authentic and complex problems based on tasks that have been designed to produce joint work for reporting project results. Collaborative project learning between subjects is essentially a learning system that allows students to actively seek, explore, and discover concepts and principles authentically by involving various groups as assessors through self-assessment and Peer Assessment. The comprehensive performance appraisal process is a multidimensional process and information is obtained from the assessment process on aspects of cognitive skills, attitudes, critical thinking, process skills and products as an integral part of the learning process by empowering students and educators.
The Effect of Zinc Oxide, Copper, and Silver Nanoparticles Synthesized by the Green Method for Controlling Strawberry Gray Mold Fungus, B. Cinerea Pers
Authors: Sareh Hashemi , Masoud Ahmadzadeh
Published: July 2023

Gray mold disease, caused by the fungus Botrytis cinerea, causes heavy losses in strawberries. The use of chemical fungicides due to the dangers for humans and the environment has caused attention to reduce their consumption and use biological methods. In this research, the effects of zinc oxide, copper, and silver nanoparticles have been synthesized from an aqueous extract of cloves, and the probiotic bacteria Lactobacillus casei by the green method was investigated on the gray mold disease of strawberries. The results showed that concentrations of 10% of zinc oxide nanoparticles synthesized from aqueous extract of cloves can completely control this pathogen on the culture medium and the fruit. Zinc and silver nanoparticles produced by Lactobacillus casei prevented 93.7% and 81% of fungal growth in the culture medium, respectively. Other treatments did not show a good inhibitory effect on the fungus. All treatments were able to prevent 100% to 50% of fungal growth after 96 hours on strawberries. The investigation of the storage characteristics showed the positive effect of the examined nanoparticles on reducing the rate of change of the physicochemical characteristics of the strawberry fruit tissue. Apparent decay was significantly reduced and samples treated with nanoparticles scored higher in sensory evaluation compared to control. Also, investigating the toxicity of nanoparticles in this experiment on the HepG2 cell line showed that Compared to the control, copper and zinc nanoparticles did not have significant toxicity on cells, but silver nanoparticles led to 25% cell death. This research provides promising results in the field of using nanoparticles for pre-harvest and post-harvest control of plant diseases.
TNFRSF13B (TACI) is differentially expressed in central nervous system metastasis.
Authors: Mamoor Shahan
Published: July 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer and lung cancer (1-3). We mined published RNA-sequencing and multiplexed gene expression data (4, 5), comparing primary and brain metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the CNS. We found that TNF receptor superfamily member 13B, encoded by TNFRSF13B, also known as TACI, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Multiplexed gene expression data (5) revealed conserved differential expression of TNFRSF13B in CNS metastasis in patients with lung cancer. TNFRSF13B mRNA was present at decreased quantities in metastasis to the brain in humans with breast cancer. Primary tumor expression of TNFRSF13B was correlated with distant metastasis-free survival and recurrence-free survival but in a contrary manner. Modulation of TNFRSF13B expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with cancer of the lung and breast.
Technical Characteristics of Incunabulum in Europe
Authors: Bolanča Stanislav , Bolanča Mirković Ivana , Pučić Ivan
Published: July 2023

Incunabula are printed materials created in Europe from the time of Johann Gutenberg's invention until 1500. Incunabula originate from the Latin language (lat. Incunabulum) and mean cradle or the beginning of something. In this paper, the representation of individual states and cities in the creation of incunabula is investigated and presented. The persons responsible for such development are also listed. Special attention is given to the presentation of Croatian incunabula. The mentioned works describe the characteristic features. Incunabula testify to a high level of culture, standards, and technological development of a particular area. The studied works reveal and confirm, as confirmed in this paper, the attitude of society towards literacy, education, and the national culture of each nation. This paper aims to comprehensively present the importance of incunabula for the development of European and Croatian culture, technological and comprehensive progress.
ВИБІР МЕТОДУ КЛАСТЕРИЗАЦІЇ ДЛЯ ЗАДАЧІ НАВІГАЦІЇ КРОКУЮЧОГО РОБОТА У НЕСТРУКТУРОВАНИХ СЕРЕДОВИЩАХ
Authors: САЗОНОВ Артем , ЗГУРСЬКИЙ Данило , КУЧКІН Олексій
Published: July 2023

Для нестандартних умов роботи роботів в більшості випадків можуть не підійти прості методи, що реалізовуються в пристроях для побутових потреб та тих, які використовуються в структурованому середовищу з дорогами, помітними перешкодами чи з певними мітками на які спирались би алгоритми виявлення перешкод та побудови маршруту. Якщо необхідно провести пошукові чи евакуаційні заходи, використовуючи крокуючих роботів, то це вже складні умови з певними особливостями. Головне завдання статті полягає у знаходженні такого методу кластеризації, який би показував гарні результати в неструктурованому середовищі з необхідною точність.  
В роботі розглянуто загальновідомі методи кластеризації даних, що поділяються на чотири основні групи, які основані на різних шляхах обробки даних та розподілення їх на кластери. Наводяться основні поняття, на яких ґрунтуються принципи та алгоритми роботи методів. На аналізі переваги та недоліки обирається група методів, яка є найоптимальнішою для заданої задачі.
Експериментальне порівняння обраних методів проводиться на хмарах точок неструктурованих середовищ. Результати аналізуються на  структуру виділених кластерів, виявлення шуму та швидкодію з урахуванням параметрів, що необхідні для роботи методу. Після аналізу якості кластеризації обирається метод з найкращими результатами для подальших досліджень. Для випробувань методу використовуються навісні, від’ємні та додатні перешкоди, такі як крони дерев, обрив та пагорби.
The efficiency of cognitive representation and its relationship to the development of historical investigation among students of the College of Education- Kirkuk University
Authors: عبدالرحمن فراس برهان الدين
Published: July 2023

The current study aims to identify (the level of efficiency of cognitive representation and its relationship to the development of historical investigation among students of the College of Education) The study sample consisted of (200) students in the Department of History, College of Education, University of Kirkuk. To achieve the objectives of the study, the researcher prepared a scale for the study represented by (the cognitive representation scale), which included (25) items, and the researcher adopted the (historical investigation scale) prepared by Abdul Qadir (2018), which included seven groups and (35) items, and the researcher verified the validity of the two tools. and their reliability. By using the appropriate statistical means, the results were analyzed that showed:

1- There is a high level of cognitive representation of information among the students of the history department.

2- The level of possession by students of the history department of the historical investigation is good.

3- There is a positive effect and a clear relationship of the cognitive representation of information on students' development of historical investigation.

According to the results, the researcher came out with a number of recommendations, including enriching the curricula with content that depends on thinking skills and nourishing the mind by increasing activities and modern strategies, training students practically on acquiring information and generating ideas and investing their abilities to raise their cognitive efficiency, and the researcher suggested conducting a study on the level of cognitive representation and its relationship to acquisition Students creative thinking skills in history.
ALLOCATION OF PROMISING TERRITORIES FOR GROWING GRAPEVINE IN THE EASTERN PART OF STEPPE ZONE OF CRIMEA
Authors:   Federal State Budgetary Institution of Science All- Russian National Institute of Wine and Winemaking  ", Rybalko E.A. ,   Magarach",   RAS,, Baranova N.V. ,   Federal State Budgetary Institution of Science All- Russian National Institute of Wine and Winemaking  "Magarach" RAS,, Chernyshov A.A. ,   Federal State Budgetary Institution of Science All- Russian National Institute of Wine and Winemaking  "Magarach" RAS,
Published: July 2023

The article presents the results of studies of the degree of favorability of agroecological conditions of the eastern part of the Steppe zone of Crimea for growing grapevine. The long-term data on weather stations of the Crimean peninsula are analyzed. The following climatic indices characterizing the growing season and the ripening period of grapes are calculated: the sum of temperatures above 20 °C, the ratio of the sum of temperatures above 20 °C to the sum of temperatures above 10 °C, the Huglin and Winkler indices, the average temperature of the growing season, the Selyaninov hydrothermal coefficient, the sum of precipitation for the year and the growing season. In addition, the main agroecological factors limiting the possibility and efficiency of growing grapes are considered: the average of the absolute minima of air temperature and the sum of active temperatures above 10 °C. With the help of geoinformation modeling, a digital complex map of the spatial distribution of index data on the analyzed territory is constructed. The distribution of territories in the central part of the Steppe zone of Crimea that are not suitable for planting vineyards is analyzed: with unfavorable soil conditions, with a height of more than 600 m above sea level, with a slope of more than 20 degrees, as well as lands of forest and nature reserves. As a result of a comprehensive analysis of agroecological conditions on the territory of the eastern part of the Steppe zone of Crimea, 10 ampeloecotopes were identified, including: on the territory of the Kirovsky district – 9, Leninsky district – 7. As a result of a comparison of agroecological conditions of selected ampeloecotopes with the requirements of grapevine varieties to growing conditions, taking into account the dependence of quality indicators of viticultural and wine products on agroecological factors recommendations on agroecological optimization of varietal composition and terroir specialization of the viticulture and wine industry in the eastern part of the Steppe zone of Crimea have been developed.
Vocabulary Learning Strategies Vis-a- Vis Vocabulary Teaching Strategies
Authors: Mohammed Abrar Kedir
Published: July 2023

Learning a foreign language entails a learner to develop special effort or ways of learning to acquire the target language effectively. This can be achieved through using appropriate learning strategies. Thus, this article looks at the relationship between vocabulary teaching methods and vocabulary learning strategies employed by students and teachers in secondary schools. Mixed methods design was used to collect quantitative and qualitative data. Data were collected through questionnaire, interview and classroom observations. Separate analyses of the data were conducted, and the qualitative findings were used to support the numeric findings. The results showed that because teachers weren't always using them to teach vocabulary lessons, vocabulary teaching strategies were found to be less effective and practical in the sample schools. It also found that the students were unable to effectively use techniques for learning new word meanings and cementing them in their long-term memory. As a result, vocabulary teaching and learning methods have not received much attention from teachers and students.  Thus, teachers should be given refreshment trainings on the teaching strategies of vocabulary so as to help students to make use of vocabulary learning strategies. Besides, it is suggested students’ training on how to use the strategies and promote the sense of autonomous learning..
Effect of Instrumental Chiropractic Manipulation on The Neck: A Systematic Review
Authors:   CEO do Instituto de Quiropraxia Livta, São Paulo, SP, Brasil, Márcio Luiz Tosi, , de Souza Melo Oliveira Maria Eduarda ,   2 Mestre em Saúde, Medicina Laboratorial e Tecnologias Forenses, Universidade do Estado do Rio de Janeiro, RJ, Brasil, Henrique Baumgarth, ,   Universidade Estácio de Sá (UNESA), Rio de Janeiro, RJ e Universidade de Vassouras (FAMAR), Vassouras, RJ, Brasil, Idogava Edgar ,   4 Edgar Idogava: Faculdade Ítalo Brasileira, São Paulo, SP, Brasil
Published: July 2023

Neck pain is a multifactorial disease and is a major problem in modern society. There is no definitive treatment for neck pain. However, different pharmacological and non-pharmacological treatments have been recommended, including instrumental chiropractic manipulation. Objective: This study will evaluate the efficacy and safety of chiropractic manipulation techniques instrumental for the treatment of neck pain. Method: Four databases were searched between October 20 and November 17, 2022: PubMed, Embase, VHL REGIONAL / LILAC, and Scopus with the keywords: "Chiropractic Manipulation", "Instrumental Chiropractic Manipulation", "neck pain", "Chiropractic". Two people independently examined the records for article inclusion. Results: 369 published articles were found, and three randomized studies were selected for this systematic review. Conclusion: There is moderatequality evidence that instrumental chiropractic manipulation reduces pain and restores cervical function without adverse effects and with complete patient safety.
Pre-Operative Electrocardiographic Patterns of Children Who Had Adenotonsillectomy at University of Benin Teaching Hospital, Nigeria
Authors:   Department of Ear, Nose and Throat/Head and Neck Surgery, University of Benin Teaching Hospital, Benin-City, Nigeria, ONYEAGWARA Carol Ngozi, , NDUAGU Samuel Uchechukwu ,   Department of Ear, Nose and Throat/Head and Neck Surgery, University of Benin Teaching Hospital, Benin-City, Nigeria
Published: July 2023

Adenotonsillitis is a relatively common condition among children attending Paediatric Otorhinolaryngology clinics. It is sometimes associated with obstructive sleep apnea (OSA) which can predispose to certain cardiac changes detectable by electrocardiography (ECG). We studied the preoperative electrocardiographic patterns of children surgically managed for adenotonsillitis in our hospital. This was a one-year retrospective study of children who had adenotonsillectomy at University of Benin Teaching Hospital, Benin-City, Nigeria between January and December 2017. Data was extracted from patients’ case files including sociodemographic parameters, clinical features and electrocardiographic profiles. These were analyzed using SPSS version 22.0. A total of 63 children were studied comprising 40 males (63.5%) and 23 females (36.5%) with a maleto-female (M:F) ratio of 1.74:1. Their ages ranged from 11 months to 192 months with mean age of 53.5±35.9 months. The modal age group of 3 to 4 years comprised 26 children (41.3%). The main presenting complaints were snoring in 58 (92.1%), mouth-breathing in 56 (88.9%), noisy breathing in 52 (82.5%) and OSA in 45 (71.4%). The duration of symptoms ranged from 5 to 96 months. Abnormal ECG was detected in 32 children (50.8%) with the common patterns being T wave abnormalities (9.5%), sinus arrhythmias (7.9%), incomplete bundle branch block (7.9%) and right ventricular hypertrophy (4.8%). There was statistically significant association between presence of OSA and abnormal ECG (p=0.043) among the children. We conclude that ECG abnormalities are relatively common among children with obstructive sleep apnoea due to adenotonsillar hypertrophy in Benin-City, Nigeria.
Correction of Cancer Medication With Herbal Preparations
Authors:   Department of Biochemistry, Faculty of Public Health, Azerbaijan Medical University, Baku, Azerbaijan, Amirova Mahira , Hasanzade Nazanin ,   Department of Biochemistry, Faculty of Public Health, Azerbaijan Medical University, Baku, Azerbaijan, Novruzov Elshad ,   Professor, Medical and Biological Physics, Treatment Faculty, Azerbaijan Medical University, Baku, Azerbaijan, Abıyev Huseyn ,   Professor, Medical and Biological Physics, Treatment Faculty, Azerbaijan Medical University, Baku, Azerbaijan, Huseynova Ellada ,   Department of Biochemistry, Faculty of Public Health, Azerbaijan Medical University, Baku, Azerbaijan, Nabi kizi Valiyeva Mahbuba ,   Professor, Academician of AS&IAS, vice-president of AS, Chief of Pharm. Thechn.& Organization Department, Azerbaijan Medical University, Baku, Azerbaijan, Efendiyev Arif Mustafa ogli ,   Department of Biochemistry, Faculty of Public Health, Azerbaijan Medical University, Baku, Azerbaijan
Published: July 2023

Nowadays cancer chemotherapy includes antibiotics, antimetabolites, alkylates, topoisomerase inhibitors and mitotic inhibitors, hormones. The search for medicinal plants that can prophylactically prevent or at least slow down the homeostasis disturbance is especially relevant. To date, the most widely used for the body restoring plant is licorice. By reducing the oxidative stress, licorice components contribute to the restoration of vitality of non-cancer cells. With a multifaceted effect on receptormediated signaling, pro- and anti-inflammatory processes, licorice compounds are drugs of choice to eliminate adverse reactions after cancer chemotherapy. This herb has long been used in the East as an adjuvant for adverse reactions. In this article, we discuss the main mechanism of anticancer drugs action along with the protective properties of licorice. Conclusion: Licorice reduces the symptoms of mucositis, anorexia, chronic fatigue during cancer treatment, has a hepatoprotective effect, helps to restore the immune cells activity
Length of Disease More than Therapy Impacts Anxiety and Depression in Multiple Sclerosis
Authors:   Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, USA, McLaughlin Patricia J , Odom Laura B ,   Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, USA, Arnett Peter A ,   Department of Psychology, Pennsylvania State University, University Park, PA, USA, Thomas Gary A ,   Department of Neurology, Milton S. Hershey Medical Center, Penn State Health, Hershey, PA, USA, Orehek Shannon ,   Department of Neurology, Milton S. Hershey Medical Center, Penn State Health, Hershey, PA, USA, Zagon Ian S ,   Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, USA
Published: July 2023

Persons with multiple sclerosis (PwMS) often report a reduced quality of life related to their anxiety and depression associated with the biological unknowns of MS. The COVID-19 pandemic increased the risk of anxiety due to the uncertainties related to vaccine efficacy and immune-suppressing disease-modifying therapies. PwMS were recruited from the Neurology Clinic of the Penn State Hershey Medical Center and asked to complete a demographic questionnaire and surveys on depression (MS-Beck Depression Inventory, MS-BDI) and the Hospital Anxiety and Depression Scale (HADS). The rationale for the study is to determine whether treatment modalities, age, and length of disease impacted anxiety and/or depression in PwMS. Data from 150 participants were included in the analyses. The overall mean age was 54.6 years with a 3.7:1 female:male ratio and mean length of disease of approximately 17 years. Mean scores of the HADS-D, and high scores (> 8) were 4.68 ± 0.3 and 10.0 ± 0.32, respectively, with no differences between males and females. The mean HADS-A score was 6.15 ± 0.36 with significant differences recorded between male and females. The mean high HADS-A score was 10.77 ± 0.40, with no differences between sexes. The mean MS-BDI score was 4.15 ± 0.7 with no differences between males and females. Analyses of anxiety scores in relationship to length of disease revealed no differences between males and females. Anxiety scores did not differ for PwMS on different disease-modifying therapies. In conclusion, the number of years that PwMS had the disease impacted anxiety levels more than the age or treatment regimen..
External Frontal Sinostomy to Drain Frontal Lobe Abscess
Authors:   ENT. Consultant, GPHC, Georgetown, Guyana, Sharma Sudhir B , Avalos Gabriel ,   Neurosurgeon, GPHC, Georgetown, Guyana, Cappell, Donyale ,   Senior Resident in ENT, GPHC, Georgetown, Guyana, Sharma Samridh ,   Research Scholar, NHS, U. K
Published: July 2023

A case of frontal sinusitis with osteomyelitis of its posterior wall producing frontal lobe brain abscess is presented, whereby the posterior wall dehiscence was exposed by external sinostomy by an ENT surgeon and then, through the dehiscence, the abscess was drained by a neurosurgeon. This is an uncommon technique of draining a frontal lobe brain abscess where no frontal bone craniotomy was required. This approach yields the least damage to the cerebral tissue as the frontal abscess was very close to posterior wall of frontal sinus and drain has to travel through minimal intracerebral distance.
Placental Site Choriocarcinoma, Vanishing Twin And Polycystic Ovary Syndrome
Authors:   Erlanger Women’s Institute for Specialized Health, UT College of Medicine, Chattanooga Units, 1751 Gunbarrel Road, Chattanooga, Tennessee 37421, USA, Hobgood Donna K
Published: July 2023

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy causing both metabolic syndrome and cancer risks. Case: This patient presented with PCOS including dysfunctional uterine bleeding, obesity, and hypothyroidism. Genetic evaluation revealed no specific findings other than probable PCOS in her mother, and review of her past history showed presence of non-metastatic choriocarcinoma in her placenta. Conclusion: This patient was the surviving twin whose vanishing twin was a probable hydatidiform mole resulting in choriocarcinoma of placental site facilitating testosterone crossing the placenta to cause androgenization. Teaching Points Vanishing twin can be considered a risk factor for polycystic ovary syndrome in surviving twin. Since polycystic ovary syndrome is not diagnosed until after puberty, history of vanishing twin can give an extra emphasis on early prevention of the many serious sequelae of this condition.
Exstrophy Bladder or Ectopia Vesica : ‘An Inside Out Affair’ A Surgical Update With Review of Current Literature
Authors:   Department of General Surgery, Al Omran General Hospital, Al Hassa, Kingdom of Saudi Arabia, UlHasan UwaisRiaz , Hasan Khathija , Qureshi Farooq Ahmed , Khan Shaima , Obong Victor Effiong , Al Nami, Abdul Aziz , AlShaqaqiq Ali Ibrahim , AbdulMajeed AbdulMajeed Mohammed , AlShuhayb Ali Hussain , Alabbad Sajjad Ahmed , zUlHasan ShehlaRia , AlMasoud Moath AbdulAziz
Published: July 2023

The word 'exstrophy,' first described by Chaussier in 1780 is derived from the Greek ekstriphein and refers to 'turn inside out'; an uncommon congenital anomaly. It has a male to female ratio of 2:1. These are congenital defects of unknown origin characterised by an abnormal development of multiple systems such as the musculoskeletal system resulting lower abdominal wall muscles separation, the skeletal system resulting in vertebral and spinal cord defects along with a diastasis of the pubic bones leading to the protrusion of hollow organs the bladder & occasionally the intestine that is exposed outside the body. The surgical challenges therefore include the reconstruction of the abdominal wall, the restoration of the bladder to its anatomical position with the aim of having a competent bladder storage system along with a cosmetically acceptable external genital with a good functional sexual outcome. .
Mirror Therapy for Total Knee Arthroplasty: A Pilot Study
Authors:   Evidence in Motion Pain Fellowship, Froedtert Holy Family Memorial Orthopaedics, Manitowoc, WI , USA, Rebne Eric , Louw , Adriaan ,   Department of Pain Science, Evidence in Motion, Story City, IA, USA, Podalak Jessie ,   Evidence in Motion Pain Fellowship, Phileo Health, Eau Claire, WI, USA, Weber Bailey ,   Hammond Henry Hospital, Geneseo, IL, USA, Van Der Geest Caitlyn ,   Bone and Joint Clinic, Plover, WI, USA, Hawk Dustin ,   Rock Valley Physical Therapy, Davenport, IA, USA, Louw Hailey ,   Department of Statistics, University of Wisconsin – Madison, Madison, WI, USA, Cox PT Terry ,   Davis Physical Therapy Building, Southwest Baptist University, MO, USA
Published: July 2023

Background: One in five patients experience persistent pain and disability after total knee arthroplasty (TKA), often driven by increased sensitization of the nervous system and pain. Pain and a sensitized nervous system are major barriers to postoperative rehabilitation impeding improved movement, and function. Objective: To determine if mirror therapy following TKA yields any positive shifts in self-reported pain, active range of motion (ROM) and nerve sensitivity (pressure pain thresholds - PPT). Design: Case series with pre- and immediate post-intervention measurements. Methods: A convenience sample of patients who just underwent TKA was recruited for the study. Prior to mirror therapy, self-reported pain, active knee flexion ROM and PPTs were measured. In hook lying, a mirror was placed between the legs, separating the surgical and non-surgical legs. Patients performed 3 sets of 10 supine heel slides with the non-surgical leg while watching the leg in the mirror, mimicking active knee flexion of the surgical leg. Results: Eighteen patients (9 female), with a mean age of 65.94 years and mean time since TKA of 7.83 days participated in the study. Immediately following mirror therapy, mean active knee flexion improved by 3.84 degrees (p = 0.001), with 10 patients exceeding minimal detectable change. Self-reported pain (p = 0.08), PPT of the surgical knee (p = 0.95), PPT of the non-surgical knee (p = 0.21) and PPT of the upper trapezius (p = 0.23) failed to show any significant improvement after mirror therapy. Conclusion: The results of this study show that mirror therapy immediately following TKA may have some benefit in improving ROM, but not pain or sensitivity of the nervous system. This is the first study exploring the immediate effects of mirror therapy in postoperative TKA.
Risk of ovarian hyperstimulation syndrome in infertile patients with PCOS treated by HP HMG
Authors:   Lamis IVF center - Misurata/Libya, Mohammed Manar Tareq , Elmahaishi, Hamza , Ben Halim Narges R , Elmahaishi MS
Published: July 2023

Polycystic ovarian syndrome (PCOS) is the commonest endocrinopathy affecting women in reproductive age group. The prevalence may vary from 8.7% to 17% depending on clinical criteria used. PCOS in women having IVF presents multiple challenges ranging from a poor to an exaggerated response, poor fertilization, poor blastocyst conversion and ovarian hyperstimulation syndrome (OHSS). OHSS is at increased risk in PCOS patients receiving fertility treatments varying from mild to severe cases which can be life threatening. Aim of the study: The presence of OHSS in infertile PCOS patients who followed non-pituitary down regulation protocol by using HP HMG injections. Materials and methods: The study type was case series study. It was done in Lamis IVF center - Misurata / Libya during the period 1- 9 -2021 to 31- 8 -2022. 118 infertile patients with PCOS were randomly selected for the study. All patients were selected started ovulation induction with non-pituitary down regulation protocol using highly purified HMG injections. Results: The age of the patients ranges between 18 and 45 years with a mean age of 30 years. The mean number of retrieved oocytes was 19.33 ± 10. The study also showed that the mean number of mature oocytes picked up was 9.41 ± 5.5 with mean success of 77.6%. Hyperstimulation syndrome was reported only in one case (prevalence of 0.8%) which was mild (needed no admission). Regarding the embryo, the mean number of transfers was 2.36 ± 0.6 with two cases showed no fertilization and 82 cases were associated with poor sperm. Conclusion: In our study OHSS in PCOS patients treated by highly purified HMG injections developed in only one case which was mild (needed no admission).
Steroid-Dependent Nephrotic Syndrome in a Child After an Allogeneic Bone Marrow Transplant: A Case Report
Authors: Zahid Uzma , Mahmood Mufti Baleegh ur Raheem
Published: July 2023

Nephrotic syndrome is a frequently encountered disease in children. It is mostly responsive to high-dose steroids, with some requiring steroid-sparing immunosuppressive regimens, or further, a renal biopsy if resistant to steroid therapy. However, nephrotic syndrome in children post-allogeneic bone marrow transplant is rarely encountered. The authors report here a child who developed nephrotic syndrome post-allogeneic bone marrow transplant for β-thalassaemia major, with the suspicion of graft-versus-host disease that was difficult-to-treat, who had frequent relapses with multiple hospital admissions, and prolonged treatment course. For the last 5 years, the disease has been in remission, on a low dose of prednisolone and mycophenolate mofetil-based maintenance immunosuppressive treatment.
Wind variability across the North Humboldt Upwelling System
Authors: Yari Sadegh , Mohrholz Volker , Bordbar Mohammad Hadi
Published: July 2023

Surface wind is taken as the primary driver of upwelling in the eastern boundary upwelling systems. The fluctuation of momentum flux associated with the variation in wind regulates the nutrient supply to the euphotic surface layer via changing the properties of oceanic mixed layer depth, the coastal and offshore upwelling, and horizontal advection. Here, the spatial and temporal variability of the surface wind field over the last seven decades across the Peruvian upwelling system is investigated. Strong fluctuations in seasonal to decadal timescales are found over the entire upwelling system. A semi-periodic wind fluctuation on an interannual timescale is found, which is closely related to the regional sea surface temperature and can be attributed to the El Niño Southern Oscillation (ENSO). However, the wind anomaly patterns during positive and negative phases of ENSO are not opposite, which suggests an asymmetric response of local wind to ENSO cycles. In addition, a semi-regular fluctuation on the decadal timescale is evident in the wind field, which can be attributed to the Interdecadal Pacific Oscillation (IPO). Our results show that the sea surface temperature over the Humboldt Upwelling System is closely connected to local wind stress and the wind stress curl. The SST wind stress co-variability seems more pronounced in the coastal upwelling cells, in which equatorward winds are very likely accompanied by robust cooling over the coastal zones. Over the past seven decades, wind speed underwent a slightly positive trend. However, the spatial pattern of the trend features considerable heterogeneity with larger values near the coastal upwelling cells.