bluuebunny/crossref_metadata_2025 huggingface dataset:
Aseptic meningitis with recurrent headache episodes, vomiting, and central fever as first manifestation of isolated neurosarcoidosis: a case report
Authors: Aloizou Athina-Maria , Gabriel Theresa Anne , Lukas Carsten , Gold Ralf , Motte Jeremias
Published: August 2024

Background

Neurosarcoidosis is a rare entity, usually within the context of systematic sarcoidosis. Isolated neurosarcoidosis and especially a manifestation with pachymeningitis is a notable rarity.

Case Report

A 26-year-old patient presented to the emergency department with acute onset, recurrent episodes of occipital headaches spreading over the whole cranium and vomiting without food consumption, for three days. The clinical examination did not reveal any neurological deficits. The laboratory exams showed no pathological findings. A CT examination with angiography did not detect any acute intracranial or vessel pathology. A lumbar puncture was performed to rule out subarachnoid hemorrhage. The results showed a lymphocytic pleocytosis of 400/µL, elevated protein levels of 1077 mg/dL and reduced glucose levels (CSF: 55 mg/dL, Serum: 118 mg/dL). Extensive infectiological examinations did not reveal any signs of infection, including Borrelia spp. and M. tuberculosis. No positive auto-antibodies or vasculitis-related auto-antibodies were detected. The CSF analysis showed negative oligoclonal bands but an isolated increase in β2-microglobulin, neopterin, and IL-2R levels. The MRI examination revealed a dural gadolinium-enhancement, pronounced in the basal cerebral structures and the upper segment of the cervical spine, consistent with neurosarcoidosis. Corticosteroid treatment rapidly led to a significant improvement of the symptoms. No systemic manifestations of sarcoidosis were found.

Conclusions

This case report aims to highlight aseptic meningitis with atypical, acute onset headache attacks as a possible manifestation of isolated neurosarcoidosis. Neurosarcoidosis is a clinical entity that requires prompt treatment to avoid permanent neurological deficits.
The design, implementation, and evaluation of a blended (in-person and virtual) Clinical Competency Examination for final-year nursing students
Authors: Mojtahedzadeh Rita , Toulabi Tahereh , Mohammadi Aeen
Published: August 2024

Introduction

Studies have reported different results of evaluation methods of clinical competency tests. Therefore, this study aimed to design, implement, and evaluate a blended (in-person and virtual) Competency Examination for final-year Nursing Students.

Methods

This interventional study was conducted in two semesters of 2020–2021 using an educational action research method in the nursing and midwifery faculty. Thirteen faculty members and 84 final-year nursing students were included in the study using a census method. Eight programs and related activities were designed and conducted during the examination process. Students completed the Spielberger Anxiety Inventory before the examination, and both faculty members and students completed the Acceptance and Satisfaction questionnaire.

Findings

The results of the analysis of focused group discussions and reflections indicated that the virtual CCE was not capable of adequately assessing clinical skills. Therefore, it was decided that the CCE for final-year nursing students would be conducted using a blended method. The activities required for performing the examination were designed and implemented based on action plans. Anxiety and satisfaction were also evaluated as outcomes of the study. There was no statistically significant difference in overt, covert, and overall anxiety scores between the in-person and virtual sections of the examination (p > 0.05). The mean (SD) acceptance and satisfaction scores for students in virtual, in-person, and blended sections were 25.49 (4.73), 27.60 (4.70), and 25.57 (4.97), respectively, out of 30 points, in which there was a significant increase in the in-person section compared to the other sections. (p = 0.008). The mean acceptance and satisfaction scores for faculty members were 30.31 (4.47) in the virtual, 29.86 (3.94) in the in-person, and 30.00 (4.16) out of 33 in the blended, and there was no significant difference between the three sections (p = 0.864).

Conclusion

Evaluating nursing students’ clinical competency using a blended method was implemented and solved the problem of students’ graduation. Therefore, it is suggested that the blended method be used instead of traditional in-person or entirely virtual exams in epidemics or based on conditions, facilities, and human resources. Also, the use of patient simulation, virtual reality, and the development of necessary virtual and in-person training infrastructure for students is recommended for future research. Furthermore, considering that the acceptance of traditional in-person exams among students is higher, it is necessary to develop virtual teaching strategies.
The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration
Authors: Cazzanelli Petra , Lamoca Mikkael , Hasler Johannes , Hausmann Oliver Nic , Mesfin Addisu , Puvanesarajah Varun , Hitzl Wolfgang , Wuertz-Kozak Karin
Published: August 2024

Background

Intervertebral disc (IVD) degeneration is a multifactorial pathological process resulting in the dysregulation of IVD cell activity. The catabolic shift observed in IVD cells during degeneration leads to increased inflammation, extracellular matrix (ECM) degradation, aberrant intracellular signaling and cell loss. Importantly, these pathological processes are known to be interconnected and to collectively contribute to the progression of the disease. MicroRNAs (miRNAs) are known as strong post-transcriptional regulators, targeting multiple genes simultaneously and regulating numerous intracellular pathways. Specifically, miR-155-5p has been of particular interest since it is known as a pro-inflammatory mediator and contributing factor to diseases like cancer and osteoarthritis. This study investigated the role of miR-155-5p in IVD degeneration with a specific focus on inflammation and mechanosensing.

Methods

Gain- and loss-of-function studies were performed through transfection of human Nucleus pulposus (NP) and Annulus fibrosus (AF) cells isolated from degenerated IVDs with miR-155-5p mimics, inhibitors or their corresponding non-targeting control. Transfected cells were then subjected to an inflammatory environment or mechanical loading. Conditioned media and cell lysates were collected for phosphorylation and cytokine secretion arrays as well as gene expression analysis.

Results

Increased expression of miR-155-5p in AF cells resulted in significant upregulation of interleukin (IL)-8 cytokine secretion during cyclic stretching and a similar trend in IL-6 secretion during inflammation. Furthermore, miR-155-5p mimics increased the expression of the brain-derived neurotrophic factor (BDNF) in AF cells undergoing cyclic stretching. In NP cells, miR-155-5p gain-of-function resulted in the activation of the mitogen-activated protein kinase (MAPK) signaling pathway through increased phosphorylation of p38 and p53. Lastly, miR-155-5p inhibition caused a significant increase in the anti-inflammatory cytokine IL-10 in AF cells and the tissue inhibitor of metalloproteinases (TIMP)-4 in NP cells respectively.

Conclusion

Overall, these results show that miR-155-5p contributes to IVD degeneration by enhancing inflammation through pro-inflammatory cytokines and MAPK signaling, as well as by promoting the catabolic shift of AF cells during mechanical loading. The inhibition of miR-155-5p may constitute a potential therapeutic approach for IVD degeneration and low back pain.
Turner Syndrome where are we?
Authors: Khan Najma , Farooqui Anam , Ishrat Romana
Published: August 2024

Turner syndrome (TS) results from the loss of one X chromosome in phenotypic females, leading to a range of complications such as short stature, cardiovascular issues, autoimmune disorders, metabolic imbalances, osteoporosis, neurocognitive deficits, hearing loss, abnormalities in endocrine functions, infertility, disruptions in bone metabolism, and neurocognitive deficits. These diverse clinical manifestations necessitate a comprehensive and multidisciplinary approach to diagnosis and management. Growth hormone therapy stands out as a fundamental treatment for addressing the challenges associated with TS. Ongoing clinical and genomic advancements contribute to an evolving understanding of TS, shedding light on its complexities and potential therapeutic interventions. Despite progress, further research is crucial to identify candidate pathways and critical biomarkers that can alleviate the syndrome’s burden. By uncovering these insights, we aim to empower individuals with TS, enhancing their overall functioning and quality of life. In this review, we have explored the prevalent co-morbidities associated with TS, drawing insights from the current literature.
Exercise induced hypoalgesia after a high intensity functional training: a randomized controlled crossover study
Authors: Tomschi Fabian , Ransmann Pia , Schmidt Alexander , Hilberg Thomas
Published: August 2024

Background

Acute physical activity often induces an acute reduction in pain sensitivity known as exercise induced hypoalgesia (EIH). The aim of this study was to investigate the effects of a high intensity functional training (HIFT) on EIH compared to a control session.

Methods

50 (age: 26.0 ± 2.7; 23 female) participants successfully conducted this study consisting of a pre-experimental test as well as a 12-minute HIFT (body-weight exercises) and a 12-minute control (supervised breathing) session in a randomized crossover design. Pre and post, pressure pain thresholds (PPT) were measured at the ankles, knees, elbows, and forehead.

Results

The HIFT resulted in a relative maximum and average heart rate of 96.2% (± 3.6%) and 91.1% (± 4.2%), respectively, and maximum and average RPE values of 19.1 (± 1.2) and 16.2 (± 1.4), respectively. Results reveal a significant ‘Intervention’ × ‘Time point’ interaction (p < 0.001) for PPT (pooled for one average value) with hypoalgesia observed following the HIFT (p < 0.001; pre: 56.0 ± 16.8, post: 61.6 ± 19.0 [Newton]) and no change following the control (p = 0.067; pre: 56.6 ± 18.4, post: 55.3 ± 18.9 [Newton]). Further, a significant ‘Time’ × ‘Intervention’ × ‘Landmark’ interaction effect (p = 0.024) is observed and all landmarks showed significant hypoalgesia following HIFT (p < 0.01), except for the right elbow and forehead. Following control, no hypoalgesia was observed at any landmark. Analysing male and female participants separately, it was observed that EIH occured only in men.

Conclusion

A HIFT using bodyweight exercises reduces pain sensitivity. Hence, combining strength and aerobically demanding exercises in a short but high intensity manner, as done in HIFT, can be seen as a usable tool to induce hypoalgesia. Yet, these results were observed only in male participants, necessitating future sex-specific research.

Trial registration

DRKS00034391, retrospectively registered on the 4th of June 2024.
Using Municipal Solid-Waste Incinerator Fly Ash, Wash Water, and Propylene Fibers in Self-Compacting Repair Mortar, Greenhouse Gas Emissions Potential
Authors: Abdi Ehsan , Asadollahfardi Gholamreza , Salehi Amirmasoud , Akbardoost Javad , Esmaeili Negar , Panahandeh Azadeh
Published: August 2024

Wash water, municipal solid waste incineration (MSWI) fly ash, and propylene (PP) fibers were employed simultaneously to produce self-compacting repair mortar (SCRM). Different SCRM mixtures were utilized, incorporating 35, 70, and 140 kg/m3 of MSWI fly ash, along with 0.1% of PP fibers. The research focused on investigating the workability, mechanical properties, and global warming potential (GWP) of SCRM. The incorporation of MSWI fly ash and wash water in SCRM resulted in reduced workability, necessitating an increase in the use of superplasticizer. Adding MSWI fly ash decreases compressive strength. The minimum compressive strength was observed when employing 140 kg/m3 of MSWI fly ash and wash water instead of tap water simultaneously. By increasing the proportion of MSWI fly ash content and correspondingly reducing the cement content in SCRM samples, there was a decrease in flexural strength. The ultrasonic pulse velocity (UPV) of all SCRM samples falls within acceptable range. Adding MSWI fly ash to SCRM reduces fracture toughness, and the concurrent use of wash water and MSWI fly ash significantly decreases fracture toughness. Incorporating PP fibers into SCRM resulted in increased compressive strength. Utilizing wash water and MSWI fly ash in SCRM significantly reduces GWP. The avoidance of wash water consumption mitigates the environmental impact of SCRM.
A metabolite-based liquid biopsy for detection of ovarian cancer
Authors: Fahrmann Johannes F. , Ghasemi Seyyed Mahmood , Han Chae Y. , Wu Ranran , Dennison Jennifer B. , Vykoukal Jody , Celestino Joseph , Lu Karen , Lu Zhen , Drescher Charles , Do Kim-Anh , Hanash Samir , Bast Robert C. , Irajizad Ehsan
Published: August 2024

Serial CA125 and second line transvaginal ultrasound (TVS) screening in the UKCTOCS indicated a shift towards detection of earlier stage ovarian cancer (OvCa), but did not yield a significant mortality reduction. There remains a need to establish additional biomarkers that can complement CA125 for even earlier and at a larger proportion of new cases. Using a cohort of plasma samples from 219 OvCa cases (59 stage I/II and 160 stage III/IV) and 409 female controls and a novel Sensitivity Maximization At A Given Specificity (SMAGS) method, we developed a blood-based metabolite-based test consisting of 7 metabolites together with CA125 for detection of OvCa. At a 98.5% specificity cutpoint, the metabolite test achieved sensitivity of 86.2% for detection of early-stage OvCa and was able to capture 64% of the cases with low CA125 levels (< 35 units/mL). In an independent test consisting of 65 early-stage OvCa cases and 141 female controls, the metabolite panel achieved sensitivity of 73.8% at a 91.4% specificity and captured 13 (44.8%) out of 29 early-stage cases with CA125 levels < 35 units/mL. The metabolite test has utility for ovarian cancer screening, capable of improving upon CA125 for detection of early-stage disease.
Machine Learning–Based Prediction of 1-Year Survival Using Subjective and Objective Parameters in Patients With Cancer
Authors: Salvador Comino Maria Rosa , Youssef Paul , Heinzelmann Anna , Bernhardt Florian , Seifert Christin , Tewes Mitra
Published: August 2024

PURPOSE

Palliative care is recommended for patients with cancer with a life expectancy of <12 months. Machine learning (ML) techniques can help in predicting survival outcomes among patients with cancer and may help distinguish who benefits the most from palliative care support. We aim to explore the importance of several objective and subjective self-reported variables. Subjective variables were collected through electronic psycho-oncologic and palliative care self-assessment screenings. We used these variables to predict 1-year mortality.

MATERIALS AND METHODS

Between April 1, 2020, and March 31, 2021, a total of 265 patients with advanced cancer completed a patient-reported outcome tool. We documented objective and subjective variables collected from electronic health records, self-reported subjective variables, and all clinical variables combined. We used logistic regression (LR), 20-fold cross-validation, decision trees, and random forests to predict 1-year mortality. We analyzed the receiver operating characteristic (ROC) curve—AUC, the precision-recall curve—AUC (PR-AUC)—and the feature importance of the ML models.

RESULTS

The performance of clinical nonpatient variables in predictions (LR reaches 0.81 [ROC-AUC] and 0.72 [F1 score]) are much more predictive than that of subjective patient-reported variables (LR reaches 0.55 [ROC-AUC] and 0.52 [F1 score]).

CONCLUSION

The results show that objective variables used in this study are much more predictive than subjective patient-reported variables, which measure subjective burden. These findings indicate that subjective burden cannot be reliably used to predict survival. Further research is needed to clarify the role of self-reported patient burden and mortality prediction using ML.
Predicates of the 3D apollonius diagram
Authors: Καμαριανάκης Εμμανουήλ
Published: August 2024

Στην εργασία αυτή μελετάμε ένα από τα κεντρικότερα κατηγορήματα το οποίο απαιτείται για την κατασκευή του 3-Διάστατου Απολλώνιου Διαγράμματος (γνωστό και ως Voronoi διάγραμμα βεβαρυμένων σημείων), το επονομαζόμενο κατηγόρημα \conflict: δεδομένων 5 σφαιρών S_i, S_j,S_k,S_l,S_m τα οποία ορίζουν μια ακμή e_{ijklm} στο Απολλώνιο διάγραμμα και μίας έκτης σφαίρας $S_q$, το κατηγόρημα αποφαίνεται ποιο υποσύνολο της $\edge{ijklm}$ θα πάψει να υπάρχει ως ακμή στο στο Απολλώνιο διάγραμματων 6 σφαιρών. Το κύριο μέλημά μας είναι η αλγοριθμική ανάλυση του κατηγορήματος αυτού, έχοντας ως βασικό στόχο την ελαχιστοποίηση του αλγεβρικού του βαθμού. Αρχικά αποσυνθέτουμε το βασικό κατηγόρημα σε υποκατηγορήματα, τα οποία βασίζονται με τη σειρά τους σε πιο βασικούς γεωμετρικοαλγεβρικούς ελέγχους. Αποδεικνύουμε ότι το σύνολο των υποκατηγορημάτων και άρα και το κεντρικό κατηγόρημα απαιτεί υπολογισμούς αλγεβρικού βαθμού το πολύ 10 για να απαντηθεί για μη εκφυλισμένες εισόδους. Επίσης, για του ίδιου τύπου τριχοτόμους, αποδεικνύουμε ότι όλα τα υποκατηγορήματα που έχουμε σχεδιάσει απαιτούν μέγιστο αλγεβρικό βαθμό 10 ή 8, εάν απαιτούν τονενδιάμεσο υπολογισμό του κατηγορήματος InSphere ή όχι.Ανάμεσα στα εργαλεία που χρησιμοποιούμε είναι ο μετασχηματισμός αντιστροφής και η συμβολική διαταραχή. Το μεγαλύτερο μέρος της ανάλυσής μας γίνεται στον αντεστραμμένο χώρο, όπου οι γεωμετρικές μας παρατηρήσεις μεταφράζονται σε αλγεβρικούς όρους.
Bempedoic acid – new agent in hiperlipidemia treatment – literature review
Authors: Frańczuk Agata , Makłowicz Aleksandra , Plizga Jakub , Głuszczyk Agnieszka , Kopczyńska Ewelina , Szpulak Angelika , Grzelka Michalina , Kuleta Katarzyna , Słychan Katarzyna , Głoskowska Julia
Published: August 2024

Hyperlipidemia is becoming more and more severe condition among modern society. High-fat diet, sedentary lifestyle, lack of physical activity are the common factors leading to overweight, obesity and problems with serum lipid control. Dyslipidemia is one of the most important agents contributing to cardiovascular diseases snd therefore lower quality of life, disability and preamature death. This forces to constatnt searching for lipid-lowering drugs, that can be successfully use in the patients suffering from poor lipid control. Bempedoic acid (ETC-1020) is one of the newest, first in the class medicine, firstly approved to use in the USA on 21st February 2020 in monotheraphy, and then on  26th February in combination with ezetimibe. It is a small synthetic prodrug molecule that is activated by acyl-CoA synthetase in the liver. Bempedoic acid inhibits competitively adenosine triphosphate citrate lyase (ACL) and as a result it stops the further production of cholesterol and fatty acids. Research shows the ability of ETC-1020 to decline of LDL-C cholesterol up to 24%. It is also responsible for total cholesterol, non-HDL-C, ApoB and hs-CRP reduction. Bempedoic acid is characterized by good pharmacokinetics and pharmacodynamics. ECT-1020 has also a good drug-to-drug interaction profile. Many clinical trials have reported efficacy and safety of use with minimal side effects. Because of its target point is located in the liver and kidney, it can be successfully use in patients with statin intolerance due to bypassing decline of muscle cholesterol biosyntheisis, that is the main cause of musculosketelar adverse effects.
Is physical activity still the key to treating obesity? - semaglutide, a new position among therapies
Authors: Makowska Karolina , Billewicz Marta , Marczyk Aleksandra , Lis Laura
Published: August 2024

Obesity is a condition characterized by excessive and abnormal accumulation of fat tissue. It disrupts energy homeostasis, leading to severe health problems. Physical activity is a significant part of reducing obesity. If sport activities are not enough, pharmacological management may be needed. One of pharmacological approaches to obesity treatment is a use of semaglutide. It is a glucagon-like peptide 1 receptor agonists (GLP-1RAs) approved for the treatment of type 2 diabetes. Semaglutide presents many pleiotropic effects and has an impact on several organ systems, such as cardiovascular, digestive, or nervous systems. Clinicals should remember about semaglutide’s complex mechanisms of actions and different adverse effects.
Code and Data Repository for Unified Framework for Choice-Based Facility Location Problem
Authors: Lin Yun Hui , Tian Qingyun , Zhao Yanlu
Published: August 2024

The choice-based facility location (CBFL) problem arises in various industrial and business contexts. The problem is based on a decentralized perspective: Companies set up chains of facilities, and customers determine from which chain or facility to seek service according to their own preferences. Essentially, customer preferences or choices play a key role in characterizing various CBFL problems, which differ mainly in the models or rules employed to characterize the choice. Consequently, a large number of formulations appear and are often solved by dedicatedly designed approaches in the literature. Such a situation significantly complicates practitioners' decision-making process when they are facing practical problems but are unsure which ad hoc model is suitable for their cases. In this article, we address this dilemma by providing a unified modeling framework based on the concept of preference dominance. Specifically, we conceptualize the choice behavior as a sequential two-step procedure: Given a set of open facilities, each customer first forms a nondominated consideration set and then splits the buying power within the set. Such an interpretation renders practitioners high modeling flexibility, as they can tailor how preference dominance is constructed according to their specific contexts. In particular, we show that our model can represent several streams of CBFL problems. To support the applicability of our model, we design an efficient exact decomposition algorithm. Extensive computational studies reveal that although the algorithm is designed for a general purpose, it outperforms most approaches that are tailored for ad hoc problems by a large margin, which justifies both the effectiveness and the efficiency of the unified framework. This repository provides data for the problem and code for the algorthm. The main folders are 'data', 'src', and 'results'. 'data': four datasets generator (and instances) used in the paper. 'src': the source code for the decomposition algorithm. 'results': high-resoultion figures in our paper All experimental results can be found in the paper (manuscript and electronic companion).
Coopetition in Platform-Based Retailing: On the Platform’s Entry
Authors: Qi Lian , Song Haotian , Xiao Wenqiang
Published: August 2024

We study the dynamic incentive interactions between a platform and a third-party seller over two stages, where the seller exerts product-value-enhancement effort in the first stage in anticipation of the platform’s potential entry in the second stage. Upon entry, the platform can exert effort to boost the value of the product sold by the platform, with positive spillovers to the value of the product sold by the platform. We show the existence of both the protective and the receptive regimes, characterizing the necessary and sufficient conditions for each regime. These conditions are of thresholds type with respect to the parameters including the degree of spillover, the referral rate, and the competition intensity. In the protective (receptive) regime, the seller is worse (better) off with the platform’s entry than without, thereby distorting effort downward (upward) from the first best to deter (induce) the platform’s entry to the products of intermediate value. Notably, if the spillover effect is negative, only the protective regime will arise. We also provide the necessary and sufficient conditions under which the platform’s nonentry commitment strictly improves the platform’s profits by restoring the seller’s effort to the first best, achieving the win-win outcome for both the platform and the seller.

This paper was accepted by Jeannette Song, operations management.

Funding: H. Song is partially supported by the Key International Cooperation and Exchange Projects of the NSFC [Grant W2411062] and the Foundation for Innovative Research Groups of the NSFC [Grant 71821002].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.00260 .
Informasi Publikasi
Authors: Sulisworo Dwi
Published: August 2024

Informasi ini mencakup: Halaman Muka, Halaman Dalam, Susunan Panitia, Kata Pengantar, Daftar Isi, dan IInformasi Terbitan.
Analysis of the Power of Transformational Leadership in Technology Integration in Faith-Based Schools: A Systematic Literature Review
Authors: Rahmatika Nuniek
Published: August 2024

Penelitian ini mengeksplorasi integrasi teknologi dalam pendidikan sebagai dimensi tambahan yang signifikan bagi kepemimpinan transformasional berbasis keyakinan melalui tinjauan literatur sistematis. Temuan menunjukkan bahwa teknologi dapat mendukung dan memperkuat nilai-nilai inti sekolah berbasis agama dalam beberapa cara: pertama, pemimpin transformasional memanfaatkan teknologi untuk mencapai visi pendidikan yang lebih inklusif dan efisien, menyediakan akses yang lebih luas terhadap sumber daya pendidikan dan pembelajaran yang dipersonalisasi. Kedua, pemimpin memastikan komunitas sekolah merasa nyaman dengan teknologi melalui pelatihan dan dukungan berkelanjutan. Ketiga, teknologi memungkinkan pendekatan pembelajaran yang lebih kreatif dan inovatif, seperti pembelajaran berbasis proyek dan kolaborasi daring, yang sejalan dengan nilai-nilai agama dalam mempromosikan kerjasama dan solidaritas. Keempat, pemimpin memastikan bahwa guru dan siswa memiliki keterampilan digital yang diperlukan untuk berpartisipasi dalam masyarakat modern, sambil memperkuat praktik keagamaan dan nilai-nilai etis. Kelima, teknologi digunakan untuk memberdayakan guru dan siswa dengan alat untuk berinovasi, berkolaborasi, dan berpartisipasi aktif dalam komunitas belajar yang dinamis. Keenam, teknologi mendukung budaya kolaboratif dan adaptif di sekolah, memungkinkan komunikasi yang lebih baik, kolaborasi lintas batas, dan adaptasi cepat terhadap perubahan. Penelitian ini menunjukkan bahwa pemimpin di sekolah berbasis agama menggunakan nilai-nilai keagamaan untuk memperkuat praktik kepemimpinan transformasional mereka, menciptakan lingkungan sekolah yang berpusat pada nilai dan memberdayakan komunitas.
Efektivitas Model Project-Based Learning terhadap Keterlibatan Siswa pada Pelajaran IPA Kelas IV
Authors: Arthanissa Shofiad’ha Fanny , Maryani Ika
Published: August 2024

Abstrak ini menyelidiki penerapan Pembelajaran Berbasis Proyek dalam pengajaran Ilmu Pengetahuan di Sekolah Dasar (SD) Negeri Puluhan. Penelitian ini bertujuan untuk mengevaluasi penerapan Project-Based Learning (PBL) dalam pengajaran Ilmu Pengetahuan, mengidentifikasi keterlibatan siswa setelah menggunakan model PBL, dan menggambarkan efektivitas PBL terhadap keterlibatan siswa. Metode penelitian yang digunakan adalah penelitian kuantitatif dengan pendekatan quasi-eksperimental dan eksperimental. Hasil analisis uji prasyarat menunjukkan bahwa data PBL memenuhi kriteria distribusi normal dan homogenitas varians, sedangkan data pengajaran konvensional tidak memenuhi kriteria distribusi normal. Pengujian hipotesis menggunakan uji t-sampel berpasangan mengungkapkan perbedaan signifikan antara keterlibatan siswa sebelum dan setelah PBL, yang mengonfirmasi efektivitas PBL dalam meningkatkan keterlibatan siswa. Kesimpulannya, penerapan PBL efektif dalam meningkatkan keterlibatan siswa dalam pembelajaran Ilmu Pengetahuan di SD Negeri Puluhan, didukung oleh hasil analisis statistik.
Peran Guru Bimbingan dan Konseling dalam Meningkatkan Motivasi Belajar: Studi Kasus di SMPK St. Yohanes Tilang
Authors: Sombo Maria Yuvensia , Prasetyo Erwin , Rahman Nurdin H. Abd.
Published: August 2024

Artikel ini berfokus pada kajian tentang bagaimana peran guru bimbingan dan konseling dalam meningkatkan motivasi belajar peserta didik. Belajar adalah usaha yang dapat dilakukan secara sadar oleh peserta didik untuk merubah sikap dan tingkah laku. Dalam meningkatkan perubahan tingkah laku dibutuhkan motivasi. Dalam kegiatan belajar, motivasi merupakan keseluruhan daya penggerak di dalam diri yang menimbulkan kegiatan belajar yang menjamin kelangsungan dari kegiatan belajar. Fenomena yang terjadi di sekolah  SMPK St.Yohanes Tilang  saat ini adalah banyak peserta didik yang  kurang  termotivasi  dalam  belajar. Faktanya dapat diamati dari perilaku peserta didik yang kurang antusias terhadap proses pembelajaran, kurang memperhatikan guru ketika menjelaskan materi,dan enggan mengerjakan tugas yang diberikan oleh guru. Menumbuhkan dan meningkatkan motivasi belajar merupakan tanggung jawab utama para guru, guru  BK  berkolaborasi dengan guru mata pelajaran, dan  guru wali kelas. Peran guru bimbingan dan konseling dalam meningkatkan motivasi belajar yaitu dilakukan dengan layanan informasi. Dengan tujuan untuk memberikan informasi terkait pemahaman yang berhubungan dengan permasalahan yang dihadapi peserta didik. Penelitian ini dilakukan terhadap peserta didik kelas VII,VIII, dan  IX, secara acak  pada  SMPK St. Yohanes Tilang Kecamatan Nita yang mengalami motivasi belajar rendah. Jenis Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus, yaitu suatu penelitian lapangan dengan tujuan mendeskripsikan ( memaparkan) semua persoalan - persoalan yang ditemukan di lapangan berupa kata-kata lisan dan tertulis, kata-kata tulisan  yakni  kutipan – kutipan data dalam bentuk narasi. Adapun pengumpulan data dilakukan melalui observasi, wawancara dan analisis dokumentasi  dengan dilakukan  Triangulasi  sumber  sebagai  keabsahan  data. Setelah memberikan  layanan  informasi, biasanya guru  BK juga akan memberikan pelayanan lanjutan bagi peserta didik yang memiliki permasalahan yang cenderung lebih kompleks  terkait dengan informasi yang diberikan. Guru BK akan memberikan layanan bimbingan belajar, bimbingan kelompok, konseling individu atau kelompok sebagai upaya dalam meningkatkan motivasi belajar peserta didik. sehingga  membawa  perubahan  dalam diri  peserta didik  yaitu   menjadi semangat dalam belajar.
Analisis Pendapatan Petani Tomat di Desa Done Kecamatan Magepanda, Nusa Tenggara Timur
Authors: Wara Wilfridus , Syurun Muhamad , Hereng Rusli
Published: August 2024

Penelitian ini bertujuan untuk Untuk mengetahui pendapatan petani tomat di Desa Done Kecamatan Magepanda dan Untuk mengetahui faktor penghambat pendapatan petani tomat. Metode penelitian yang digunakan adalah deskriptif kualitatif. Penelitian ini di lakukan di desa done kecamatan magepanda Kabupaten Sikka. Dengan memiliki sumber data primer dari penelitian ini yakni dari wawancara langsung dengan warga Desa Done dan sekunder yakni dari beberapa sumber buku dan referensi lainnya. Penulis menggunakan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi. Untuk menganalisis data penulis menggunakan triangulasi. Data yang diperoleh dari penelitian ini berdasarkan luas lahan usahatani di Desa Done Kecamatan Mageoanda dengan luas lahan 1 hektar (100 are). Dalam sekali panen, petani memperoleh 200 kg - 320 kg tomat yang dihasilkan. Hasil yang didapatkan petani dari 200 kg - 320 kg tomat yang dipanen dengan menentukan harga jual sebesar Rp.20.000. Maka total yang didapatkan petani adalah sebesar Rp.4.000.000 sampai Rp.6.000.000. Yang menjadi faktor penghambat pada pendapatan petani tomat di Desa Done Kecamatan Mageoanda yaitu:  Kendala abiotik yang mencakup banjir, irigasi, ketersediaan air, hujan, cuaca dan kesuburan tanah; Kendala pada teknologi dan agronomi seperti: kualitas benih, kualitas buah tomat, produktivitas yang rendah, metode bercocok tanam yang tidak efektif, ketersediaan pupuk dan pestisida; dan Tantangan biotik, seperti serangan hama penyakit.
Tour Guide Performance: An Analysis of English Mastery by Sikka’s Tour Guide
Authors: Rif’at Ahmed , Nasa Rikardus , Mayaputri Velmi
Published: August 2024

Tour guides play a crucial role as frontline personnel in the tourism sector. By leveraging their expertise in the attractions and cultural aspects of a destination, along with their effective communication with tourists using different languages. In fact, not all tour guides, even those who are certified, have good foreign language skills, resulting in interpretation errors in recognizing tourist destinations and their distinctive culture. This research aims to analyze the problems faced by tour guides related to English mastery. This research uses a qualitative method that allows researchers to gain an in-depth understanding of the problem under study through descriptive and interpretive data analysis. By conducting an interview, the researcher can explore various points of view and obtain data that is rich in context and then conclude with documentation. The results of this research show that tour guides in Sikka district have several problems. The first is the difficulty of communicating with tourists, especially those from Australia, China and France who have different accents and pronunciation of English than usual, so it is necessary to learn related listening skills and various accents and dialects of English from various countries. Then, the tour guide often found tourists who cannot speak English, so the role of technology such as translator applications is needed to overcome these problems. Furthermore, there are tour guides with non-English educational backgrounds so that periodic training needs to be held specifically for English according to the needs of tour guides. On the other hand, proficiency in vocabulary poses a significant challenge. An illustration of this can be seen in the case of tour guides specializing in the diver division, who are required to attain mastery in the vocabulary associated with marine biota. The role of the tourism department is needed by giving awards to tour guides so that the tour guide is motivated to improve their English skills.
Strategi Guru dalam Meningkatkan Motivasi Belajar Peserta Didik pada Mata Pelajaran IPS Terpadu Kelas VII di SMP PGRI 3 Paga Kecamatan Paga
Authors: Suryanti Patrisia Beatris Wedy , Abd. Rahman Nurdin H. , Fitri Muhammad
Published: August 2024

Strategi guru dalam meningkatkan motivasi belajar sangat diperlukan saat pembelajaran. Motivasi yang diberikan oleh guru akan membuat peserta didik selalu bersemangat dalam mencapai tujuan pembelajaran. Tujuan penelitian untuk mengetahui strategi guru dalam meningkatkan motivasi belajar peserta didik pada mata pelajaran IPS Terpadu di SMP PGRI 3 Paga kecamatan Paga. Metode penelitian adalah penelitian kualitatif dengan pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Hasil penelitian adalah guru telah memiliki strategi dalam memotivasi belajar peserta didik pada mata pelajaran IPS Terpadu yaitu penerapan metode pembelajaran yang beragam, memaksimalkan penggunaan media belajar, membuat peserta didik lebih aktif, memberikan penghargaan dalam belajar dan menciptakan suasana kelas yang kondusif.
Dimensi Pembelajaran Multiliterasi Kurikulum Finlandia Berbasis Virtual Reality untuk Pendidikan di Indonesia
Authors: Hidayah Nur
Published: August 2024

Dimensi pembelajaran multiliterasi adalah pengertian rinci atau bagian-bagian dari penerapan multiliterasi pada kurikulum Finlandia terkait multiliterasi. Teknologi VR adalah teknologi yang awalnya digunakan dalam persoalan mengenai internet, dunia digital, dan permainan virtual. Tujuan dari penelitian ini adalah untuk menelaah mengenai dimensi pembelajaran multiliterasi kurikulum Finlandia dengan penggunaan VR (Virtual Reality) pada pendidikan di Indonesia. Jenis penelitian ini adalah penelitian kualitatif dengan metode studi Pustaka. Melalui penelitian ini diharapkan dapat menjadi landasan teori tentang penggunaan VR pada dimensi pembelajaran multiliterasi. Hasil dari penelitian ini adalah landasan teori tentang dimensi pembelajaran multiliterasi sesuai kurikulum Finlandia, VR (Virtual Reality), dan VR pada dimensi pembelajaran multiliterasi.
Identifikasi Keanekaragaman Jenis Lumut (Bryophyta) di Kawasan Wisata Air Panas Blidit Desa Egon Buluk sebagai Media Pembelajaran
Authors: Moa Christianus , Syafriati Yulimira , Ernaningsih Dian
Published: August 2024

Tumbuhan lumut (Bryophyta) merupakah salah satu tumbuhan tingkat rendah yang memiliki kemampuan yang dapat hidup di berbagai substrat seperti permukaan tanah,bebatuan,maupun menempel di pohon-pohon. Karena kemampuan yang yang istimewa tersebut seringkali lumut disebut sebagai tumbuhan pioneer. Keberadaan tumbuhan lumut di kawasan air panas blidit sampai saat ini belum terdata dan terdokumentasikan dengan baik. Tujuan dari penelitian ini adalah untuk mengetahui jenis keanekaragaman serta substrat yang ditumbuhi oleh tumbuhan lumut (Bryophyta) di kawasan wisata Air Panas Blidit. Penelitian ini dilaksanakan di kawasan wisata Air Panas Blidit Desa Egon Buluk, Kecamatan Waigete, Kabupaten Sikka, Provinsi Nusa Tenggara Timur dan di Laboratorium MIPA Fakultas Keguruan dan Ilmu Pendidikan Universitas Muhammadiyah Maumere pada bulan april 2024. Penelitian ini menggunakan metode jelajah (eksplorasi). Teknik pengambilan sampel dilakukan dengan metode purposive sampling yaitu menjelajahi daerah sekitar air panas blidit, yang dibagi menjadi 3 area terdiri dari area 1 pada tangga menuju kawasan Air Panas Blidit,area 2 pada jalur aliran air menuju kawasan Air Panas Blidit dan area 3 pada titik lokasi kawasan Air Panas Blidit. Berdasarkan hasil penelitian, ditemukan 10 jenis lumut yang tergolong dalam 6 famili dengan keanekaragaman jenis lumut di air panas blidit tergolong dalam kategori sedang dengan nilai H’ = 2,21. Tumbuhan lumut yang ditemukan di air panas blidit memiliki ciri dan karakter yang berbeda-beda. Substrat yang ditumbuhi oleh tumbuhan lumut di kawasan wisata air panas blidit yaitu pada bebatuan sebanyak 13 % (4 jenis), tanah 20% (8 jenis),tangga beton 35% (9 jenis), batang pohon 9% (1 jenis) dan kayu lapuk 23% (6 jenis).
Clima Organizacional no desenvolvimento de metodologias – Revisão de Literatura
Authors: Oliveira Filho Josian Fernandes de , Viana Diego Carvalho , Silva Iracema Rocha da , Jacinto John Jacinto Santos
Published: August 2024

O clima organizacional é importante para o sucesso de uma empresa porque é um forte indicador da qualidade de vida dos profissionais. O propósito do artigo é revisar sobre o tema o clima organizacional e propor sugestões e estratégias de melhoria. Esta investigação foi elaborada por meio de estudo exploratório e com detalhamento do modelo elaborado por Litwin e Stringer. Foi observado que o processo de trabalho e a autonomia na tomada de decisões são bastante sólidos e considerados favoráveis. Assim, embora o clima seja considerado aceitável, é necessário aprimorar a motivação individual para, posteriormente, beneficiar o bem coletivo. Isso ajudará a evitar conflitos de interesses entre os setores e promoverá um ambiente de trabalho mais harmonioso e produtivo. As sugestões e estratégias de melhoria devem ser direcionadas para fortalecer o apoio mútuo entre os membros da equipe, incentivar a colaboração e a comunicação aberta, e promover um senso de pertencimento e engajamento no ambiente de trabalho. Essas medidas podem contribuir para elevar o nível de satisfação e motivação dos colaboradores, resultando em uma atmosfera organizacional mais positiva e produtiva. A motivação individual deve ser aprimorada para beneficiar o bem coletivo, evitando conflitos de interesses entre os setores e promovendo uma cultura de colaboração e comunicação aberta.
Sistema integrado de produção: percepção agroecológica para sustentabilidade e segurança alimentar na produção rural da grande ilha de São luís, Maranhão
Authors: Silva Karla Karliane Pereira
Published: August 2024

O projeto ALI Rural é uma iniciativa que busca fortalecer os pequenos negócios rurais por meio de ações de promoção do extensionismo tecnológico e estímulo à inovação. O estudo possui o objetivo de promover os produtores rurais através do fortalecimento da comercialização de produtos mais saudáveis com a pretensão de atingir a sustentabilidade dos negócios na região norte do Maranhão. As ferramentas aplicadas durante a jornada ALI Rural e as soluções propostas a fim de elevar a maturidade da empresa, proporcionam melhorias na gestão e estimulam a competitividade no meio rural. O projeto foi desenvolvido nos municípios de São Luís, Raposa, São José de Ribamar e Paço do Lumiar, com a participação de 15 produtores a cada ciclo das mais diversas cadeias produtivas do agronegócio e dois produtores que atuam no ramo do turismo rural. A metodologia aplicada contempla o desenvolvimento de ações de inovação, englobando cinco dimensões centrais e quatro dimensões orbitais, utilizando ferramentas como o Radar da Inovação, Plano de Melhorias, Diagrama Espinha de Peixe e Business Model Canvas. Foi possível focar na dimensão de melhoria de processo produtivo com foco na prática de inovações para tornar as atividades sustentáveis. Dessa forma, trazer para vida dos proprietários algo que eles já tinham na bagagem, mas que já haviam esquecido por sempre trocar e optar pelos modelos convencionais. Ao final da jornada foram observados avanços na gestão e na produtividade, principalmente relacionadas às dimensões de melhoria de processo produtivo, novos produtos e redução de custos.
Projeto ALI rural do Sebrae contribui para aumentar o faturamento e a produtividade de pequenos negócios rurais no Leste Maranhense
Authors: Damasceno Paulo Junio Silva , Borges Rosa Amélia Dias , Costa Deniz Sousa , Carvalho Débora Araújo de
Published: August 2024

A agricultura familiar é crucial para a economia brasileira, mas enfrenta desafios no Maranhão, como baixa produtividade e falta de assistência técnica. Este artigo avalia os efeitos do projeto ALI rural no faturamento e inovação de pequenos negócios rurais em Chapadinha, Maranhão. No primeiro ciclo do projeto, 15 produtores de cinco municípios foram acompanhados por sete meses em várias cadeias produtivas, como apicultura e fruticultura. A metodologia do ALI rural incluiu dez encontros, registrando o faturamento no início e final e usando a ferramenta Radar da Inovação para avaliar a maturidade em cinco dimensões. A dimensão de controles gerenciais mostrou a maior evolução: 50% dos produtores começaram a fazer controles financeiros e de produção, e os outros 50% aprimoraram seus processos. Dos 12 produtores acompanhados, dez (83%) tiveram dados para medir o faturamento inicial; 70% deles aumentaram o faturamento em média de 169%. Cerca de 33% lançaram novos produtos, 80% acessaram novos mercados e 58% ampliaram as vendas online. As inovações do projeto ajudaram a superar os desafios da sazonalidade produtiva. Embora a sazonalidade produtiva diminua o faturamento em negócios rurais, as inovações resultantes da aplicação da metodologia que constitui o projeto ALI rural do Sebrae auxiliam na superação desse gargalo.
Oportunidades e desafios para a inovação rural na agricultura familiar no cerrado sul maranhense
Authors: Santos Raianara Andrade dos , Sobrinho Souta Elly Jonhson da Silva , Coelho Sandra Barcelos , Carvalho Débora Araújo de
Published: August 2024

O munícipio de Balsas e São Raimundo das Mangabeiras, localizados no cerrado sul maranhense, se destacam no agronegócio de produção de grãos. O objetivo deste manuscrito é apresentar as principais inovações tecnológicas adotadas por produtores rurais em dois municípios do Cerrado Sul Maranhense durante a Jornada ALI rural. O projeto ALI rural foi executado em dois ciclos de oito meses cada em Balsas e São Raimundo das Mangabeiras, no estado do Maranhão, com 15 produtores rurais acompanhados em cada ciclo. A jornada da inovação consistiu em dez encontros, sendo oito individuais nas propriedades rurais dos produtores e dois coletivos, buscando promover a aprendizagem em conjunto. Foram aplicadas diversas ferramentas, incluindo o radar da inovação e o plano de ação, que são discutidos neste manuscrito para apresentar os resultados obtidos. Dentre as ações realizadas em todas as dimensões do radar da inovação, destacam-se iniciativas nos controles gerenciais, como o controle financeiro e operacional para auxiliar na tomada de decisões. Na dimensão marketing e vendas, foram criados perfis no Instagram e WhatsApp para as empresas, visando aprimorar a divulgação dos produtos. Além disso, foi realizada a aquisição de uma máquina de cartão para facilitar novas formas de pagamento. Na dimensão de novos produtos, observou-se a aquisição de equipamentos, como seladoras de potes e sacos, visando melhorar as embalagens e explorar novas oportunidades de inovação por meio de consultorias e do programa EMPRETEC rural. Apesar dos diversos desafios enfrentados, os produtores rurais demonstraram resiliência na manutenção de suas produções e propriedades.
O Papel do Programa Ali Rural na Redução de Custos das Cadeias Produtivas na Microrregião Baixada Maranhense
Authors: Matos Sâmia dos Santos , Jacinto John Jacinto Santos , Viana Diego Carvalho
Published: August 2024

O Programa Agente Local de Inovação Rural (ALI rural), uma iniciativa do Sebrae, foi concebido com o propósito de fortalecer os pequenos negócios rurais. Essa iniciativa se destaca por promover o extensionismo tecnológico, estimular a pesquisa e fomentar o desenvolvimento de processos inovadores. O presente trabalho teve como objetivo principal avaliar o impacto do Programa ALI rural na redução de custos em diversas cadeias produtivas na microrregião da Baixada Maranhense. A jornada ALI rural foi implementada nos municípios de Vitória do Mearim e Arari, situados na região norte do Maranhão, por meio de dez encontros, sendo oito individuais e dois coletivos. Ao longo dessa jornada, foi desenvolvida uma metodologia que visava proporcionar melhorias às empresas rurais participantes. Os resultados revelaram que, ao término da jornada ALI, houve um aumento nos valores em comparação com o início (T0). Observou-se que 12 dos 14 produtores monitorados experimentaram acréscimos, variando entre 0,25, 0,50, 0,75 e 0,95 grau. Este aumento indica uma melhoria significativa nas condições financeiras desses produtores. Em suma, os resultados apontam que o Programa ALI rural desempenhou um papel efetivo na redução de custos para os produtores nos municípios de Vitória do Mearim e Arari, no estado do Maranhão.
Balancing the books
Authors: Jones Gemma
Published: August 2024

Gemma Jones discusses how to best manage financial costs during training as a dental nurse.
Learning the ropes
Authors: Hawkhead Carmen
Published: August 2024

Carmen Hawkhead delivers some helpful tips for trainee dental nurses at the beginning of their careers.
Switching one bad habit for another?
Authors: Balaji Selvaraj
Published: August 2024

Selvaraj Balaji discusses developing knowledge and solutions for tobacco cessation.
The five R's
Authors: Waters Rebecca
Published: August 2024

Rebecca Waters outlines the leading principles of waste management.
Seeking a solution
Authors: Burrow Hannah
Published: August 2024

Hannah Burrow discusses the issue of memory decay in dental patients.