bluuebunny/crossref_metadata_2025 huggingface dataset:
National and Cultural Peculiarities of the Use of Phraseological Expressions in Chinese and Russian
Authors: Jia Junwen
Published: April 2023

Idioms are the essence of a people's language and have a distinctive important national character. An idiom is a frequently used phrase that plays an important role in everyday communication. The differences in the structure, metaphorical use, the origin of the precedent phrases reveal the individuality of the two languages and cultures. The article provides a comparative analysis of the use of idioms in Russian and Chinese. Although modern vocabulary is a part of the language, which has greatly developed and changed, this does not mean that all its laws are in a state of fluidity there are two kinds of lexical laws - static and dynamic. The aim of the research is to carry out the analysis of Russian and Chinese phraseological expressions. The subject of the research is the national and cultural peculiarities of the use of phraseological expressions. Methods of research - analysis of scientific sources on the topic of research. Results of work. In Russian language idioms are called "salt of life" and "fruit of historical wisdom". In this article we will first try to discuss the lexical features of modern language to shed light on this topic. The results of the study can be applied in further comparison of the phraseological units of the two countries. The novelty of the research is due to the lack of scientific elaboration of the issue. All this actualizes the chosen topic of our research.
Prevalência de Transtornos Mentais Comuns em familiares de pessoas internadas na unidade de emergência hospitalar
Authors: Cedraz Claudiane Silva Pereira , Freitas Kátia Santana , Souza Geysimara Santos Silveira , Portela Pollyana Pereira , Pinho Paloma de Sousa , Silva Filho Aloisio Machado da , Boaventura Jéssica Esteves Martins , Cardoso Monneglesia Santana Lopes
Published: April 2023

Objetivo: Avaliar a prevalência de Transtornos Mentais Comuns (TMC) em familiares de pessoas internadas na unidade de emergência hospitalar. Métodos: A amostra foi constituída por 143 familiares de pessoas internadas na unidade de emergência clínica de um hospital público de grande porte na cidade de Feira de Santana - Bahia. Para a mensuração de suspeição e rastreamento para TMC do TMC foi utilizado o Self- Reporting Questionnaire considerando o ponto de corte para a suspeição de TMC a presença de sete ou mais respostas positivas. Resultados: Dos familiares entrevistados 52,4% sofriam com TMC, destes 78,3% eram do sexo feminino e a maioria, 60,1%, residia em Feira de Santana. Conclusão: o impacto causado pela hospitalização de um parente na unidade de emergência pode desencadear sintomas psíquicos que prejudicam a integridade mental dos familiares, requerendo da equipe interdisciplinar em saúde a busca por preparo específico para o reconhecimento dessas fragilidades e intervenção.
Tratamento da fratura do ângulo mandibular
Authors: Gaia Luiz Gilberto Tenório Malta , Santos Micael Luiz Sabino dos , Teixeira Lorena Gabrielle Alves , Matos Camila Holanda Cavalcante , Pimentel Davy Buarque de Souza , Binas Junior Luciano Viana , Silva Neto João Correia da , Oliveira Deborah Pereira de , Andrade Lilian Stefanne Vital de , Macêdo Lucas Fortes Cavalcanti de
Published: April 2023

Objetivo: Descrever sobre as fraturas de ângulo mandibular, no qual o tratamento proposto foi utilizando a técnica de champy. Revisão bibliográfica: O trauma facial torna-se cada vez mais comum na população e as fraturas mandibulares ocorrem com mais prevalência em acidentes de trânsito e agressões físicas, afetando as estruturas anatômicas da face, sendo a região do corpo e côndilo as mais atingidas já o processo coronoide é o menos acometido assim requer do profissional um tratamento efetivo. O tratamento proposto permite que a técnica de champy possa ser realizada com confiança, pois apresenta baixas complicações. Somado a isso, pode possibilitar um curto tempo cirúrgico quando comparada as outras técnicas, melhor pós operatório, baixos índices de complicações, além de diminuir possíveis lesões nervosas. Considerações finais: Com a realização desse estudo evidencia-se que a técnica de champy possibilita uma redução no tempo cirúrgico quando comparado com outras técnicas, dissecção tecidual e baixos índices de complicações.
Hyponatremia in Acute Decompensated Heart Failure as a Predictor of Acute Cardiorenal Syndrome Type-1
Authors: Syed Meharunnisha
Published: April 2023

Objectives:

Acute cardiorenal syndrome (CRS type-1) refers to an acute worsening of heart function, leading to acute kidney injury (AKI), frequently complicating acute decompensated heart failure (ADHF). This study aims to investigate whether hyponatremia, is a surrogate marker for the development of AKI in patients admitted with ADHF.

Materials and Methods:

Sample size – 100 patients with ADHF. Age – More than 18 years. Investigations – 2D-ECHO, N-terminal pro-brain natriuretic peptide, kidney function test, estimated glomerular filtration rate, USG abdomen, complete blood picture, chest X-ray, and complete urine examination.

Results:

On analysis of data, 63.5% (n=33) of patients who had hyponatremia (n=45) eventually developed AKI during hospital stay, whereas 36.5% (n=19) of patients who did not have hyponatremia (n=36) developed AKI. Hyponatremia was found to be a statistically significant (P = 0.001) predictor of increased incidence of AKI in a predetermined group of patients with HF in our study, and ADHF patients with hyponatremia have a 5.21-fold higher risk of developing AKI (95% CI, 2.20–12.36) than ADHF patients without hyponatremia.

Conclusion:

Hyponatremia predicts complications while admission in heart failure patients like type-I CRS and it has also been shown that comorbidities could play an important role in the presence or absence of hyponatremia and could even influence the length of hospital stay attributed to lower serum sodium levels which need further clinical trials.
Bayesian Deep Learning Applied to LSTM Models for Predicting COVID-19 Confirmed Cases in Iraq
Authors: Hassan Masoud Muhammed , Ahmed Dozdar
Published: April 2023

The COVID-19 pandemic has had a huge impact on populations around the world and has caused critical problems to medical systems. With the increasing number of COVID-19 infections, research has focused on forecasting the confirmed cases to make the right medical decisions. Despite the huge number of studies conducted to forecast the COVID-19 patients, the use of Deep Learning (DL) and Bayesian DL models are limited in this field in Iraq. Therefore, this research aims to predict the confirmed cases of COVID-19 in Iraq using classical DL models such as, Long-Short-Term-Memory (LSTM) and Bayesian LSTM models. In this study, Bayesian Deep Learning (BDL) using LSTM models was used to predict COVID-19 confirmed cases in Iraq. The motivation behind using BDL models is that they are capable to quantify model uncertainty and provide better results without overfitting or underfitting. A Monte Carlo (MC) Dropout, which is an approximation method, is added to the Bayesian-LSTM to create numerous predictions for each instance and evaluate epistemic uncertainty. To evaluate the performance of our proposed models, four evaluation measures (MSE, RMSE, R2, MAE) were used. Experimental results showed that the proposed models were efficient and provided an R2 of 0.93 and 0.92, for vanilla LSTM and Bayesian-LSTM, respectively. Furthermore, the two proposed models were optimized using ADAM and SGD optimizers, with the results revealing that optimizing with ADAM provided more accurate results. Thus, we believe that these models may assist the government in making critical decisions based on short-term predictions of confirmed cases in Iraq.
A clinical case of choroideremia
Authors:   S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery», Volgograd Branch, Khzardzhan Y.Y. , Balalina M.A. ,   S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery», Volgograd Branch, Balalin A.S. ,   S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery», Volgograd Branch, Melikhova I.A. ,   S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery», Volgograd Branch
Published: April 2023

Purpose. To present an overview of a choroideremia clinical case. Material and Methods. The article presents a clinical case of a 19-year-old patient with complaints of low distance vision, narrowing of the visual field and nictalopia since childhood. The patient underwent complex ophthalmological examination including visometry, autorefractometry, tonometry, biomicro-ophthalmoscopy with Goldman lens, computer perimetry, optical biometry, optical coherence tomography with angiography function (AngioOCT), fundus photoregistration with autofluorescence, electrophysiological examination (EP). The patient was consulted by a geneticist to confirm the basic diagnosis. Results. Visual acuity: OD = 0.1 Sph -2.0 = 1.0; OS = 0.15 Sph -1.5 = 1.0. The anterior-posterior eyeball size: OD – 24.98 mm, OS – 25.0 mm. Computer perimetry revealed narrowing of visual fields up to 10 degrees in both eyes, which correlated with changes in autofluorescence. According to EP, electrical sensitivity threshold: OD 198 µA, OS 202 µA, electrical lability: OD 37 Hz, OS 35 Hz. High visual acuity with correction in patient C. is caused by the macula condition, according to the results of AngioOCT. The retinal pigment epithelium and chorioid are thin. Chorioid outside the macular area lacks the Sattler's layer. Based on the results of a consultation with a geneticist, a pathogenic variant of the nucleotide sequence was detected in the CHM gene (chrX:85213886). Conclusion. Choroideremia is a rare genetic disease with a specific clinical picture and progressive development of visual disorder. Proper and early diagnosis allows the prevention of the disease, including prenatal diagnosis, and the development of new therapies. Keywords: choroideremia, genetic choroidal diseases, optical coherence tomography, autofluorescence, electrophysiological examination
Partial tamponade of the vitreal cavity with sterile air as a way to prevent postoperative hemophthalmia in patients after silicone oil removal
Authors:   Orenburg branch of The S. Fyodorov Eye Microsurgery Federal State Institution, Chuprov A.D. , Firsov A.S. ,   Orenburg branch of The S. Fyodorov Eye Microsurgery Federal State Institution
Published: April 2023

Purpose. To improve the technique for silicone oil removal from vitreal cavity. Material and methods. A technique for silicone oil removal with simultaneous prevention of intravitreal bleeding in the early postoperative period was developed and tested on 44 patients. For a comparative assessment of the effectiveness of the proposed methodology, a pilot prospective case-control study was conducted. The total number of observations was 40 patients with a diagnosis of operated retinal detachment, avitria, silicone tamponade. The main group (20 observations) included patients who underwent surgery using the proposed technique. The control group (20 observations) included patients who underwent surgery in the traditional way (after silicone removal, the vitreal cavity was filled only with saline solution). Results and discussion. All patients from the first group were discharged on the first day after the operation; only 80 % of patients from the control group were discharged on the first day. In the main group of patients, there were no cases of postoperative hemophthalmos; in the control group, this complication was noted in 20 % of the study participants. The proposed technique allows to significantly reduce the frequency of intravitreal bleeding in the early postoperative period after the silicone oil removal from the vitreal cavity, which helps to reduce the time of postoperative rehabilitation of patients and improve visual acuity – a key criterion for the quality of medical care for patients with vitreoretinal pathology. Keywords: silicone oil removal, hemophthalmos
A clinical case of surgical treatment of recurrent macular hole in an eye with a high degree of myopia
Authors:   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Sharko A.S. , Mironov A.V. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Kutin I.M. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Magaryan T.O. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow
Published: April 2023

Purpose. To present a clinical case of surgical treatment of recurrence of a more than once operated full-thikness macular hole in an eye with a high myopia. Material and methods. Patient L., born in 1948, with high myopia in both eyes (–9.00D), was previously operated on at another medical institution for a full-thikness macular hole in the right eye. From the anamnesis it is known that 3 unsuccessful surgical interventions were sequentially performed for a penetrating macular rupture of the right eye without achieving anatomical closure and relapses in the early postoperative period. In connection with the recurrence of a penetrating macular rupture, the patient underwent reoperation, taking into account the anatomical and morphological features of the myopic eye. Results. The study of clinical and morphofunctional results in the postoperative period revealed complete closure of the macular hole, anatomical restoration of the foveolar contour according to OCT data, and an increase in the objective vision of the operated eye. Conclusions. In the surgical treatment of the full-thikness macular hole in patients with a high myopia, it is necessary to take into account the anatomical and morphological features of the myopic eye. Improvement in the technique of macular surgery, the use of special tools and techniques for the complete removal of epiretinal membranes, peeling of the inner limiting membrane allows to achieve closure of the macular hole and obtain good anatomical and functional results in this category of patients. Keywords: full-thikness macular hole, platelet-rich plasma, internal limiting membrane
Ophthalmologic manifestations in the posterior segment of the eye after coronavirus infection
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Belyaeva A.I. , Stanishevskaya O.M. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Safronova M.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Glock M.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Malinovskaya M.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Dulchenko V.S. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Chernykh V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk
Published: April 2023

An outbreak of SARS-CoV-2 coronavirus infection has caused 667 million cases. COVID-19 is a severe acute respiratory infection caused by the SARS-CoV-2 coronavirus. The virus primarily affects the respiratory system and causes from mild signs, respiratory infection, to a severe course, acute respiratory distress syndrome. Multiple ophthalmologic manifestations in both the anterior and posterior segment of the eye are increasingly reported in the literature. Purpose. To present clinical cases of postocular ophthalmic manifestations on the ocular fundus. Material and methods. Four clinical cases of ophthalmologic manifestations in the posterior segment of the eyes that developed after a coronavirus infection were presented. All patients underwent ophthalmological examination including visometry, anterior segment biomicroscopy, as well as ophthalmoscopy with non-contact Volk 78D lens, optical coherence tomography (OCT) of macular area and OCT in angioregim (DRI OCT Triton plus, Japan). Treatment and recommendations were individualized according to ophthalmological indications. Results. Stabilization of postocular ophthalmic manifestations in the posterior segment of the eye. There was an increase in maximum corrected visual acuity (MCOZ), reduction of macular edema, adherence of neuroepithelial detachment (ONE). Conclusion. It is necessary to pay attention to the complaints of the visual organ in patients with COVID-19 in the early stages of the disease and in the nearest months after recovery. Our clinical observations show the necessity of further study of pathogenesis, clinic and treatment methods of ocular complications associated with COVID-19. Keywords: coronavirus disease, postthrombotic retinopathy, macular neovascular membrane, central serous chorioretinopathy
Choriocapillaries alteration in patients with paracentral acute middle maculopathy
Authors:   Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russia, Burnasheva M.A. , Kalinicheva Y.A. ,   Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russia
Published: April 2023

Purpose. To evaluate with optical coherence tomography angiography the status of the choriocapillaris in the eyes of patients with resolved paracentral acute middle maculopathy (PAMM). Method. Nine patients with unilateral resolved PAMM, 14 age-matched healthy individuals, and 16 age-matched patients with unilateral retinal vein occlusion (RVO) were included. The choriocapillaris flow area, and the number of choriocapillaris flow voids was compared between the eyes of healthy individuals, both eyes of the PAMM patients, and the fellow eyes of unilateral RVO patients. Results. The number of choriocapillaris flow voids in the unaffected eyes of PAMM patients was statistically significantly higher than in the eyes of healthy individuals (p < 0.001) and in the fellow eyes of unilateral RVO patients (p = 0.022). The choriocapillaris flow area in the unaffected eyes of PAMM patients was statistically significantly lower than in the eyes of healthy individuals (p < 0.001) and in the fellow eyes of unilateral RVO patients (p = 0.019). There was no difference in the status of the choriocapillaris between two eyes of PAMM patients. Conclusion. Eyes of patients with resolved PAMM have a substantial decrease of choriocapillaris perfusion. Keywords: paracentral acute middle maculopathy; choriocapillaris; vessel density; optical coherence tomography angiography; retinal vein occlusion
Dynamic changes of intraocular pressure produced by intravitreal injections of aflibercept and brolucizumab in the treatment of neovascular form age-related macular degeneration
Authors:   Research Institute of Eye Diseases, Moscow, Russian Federation, Andreeva Y.S. , Alharki L. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Shelankova A.V. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Plyukhova A.A. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Savochkina O.A. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Budzinskaya M.V. ,   Research Institute of Eye Diseases, Moscow, Russian Federation
Published: April 2023

Purpose. To study the dynamic changes of intraocular pressure (IOP) produced by intravitreal injection (IVI) of aflibercept and brolucizumab in patients with neovascular form of age-related macular degeneration (nAMD). Material and methods. This study included 40 patients with nAMD, who were randomly divided into 2 groups of 20 people. In 1st group, patients received aflibercept, in group 2nd – brolucizumab. IOP was measured with an ICare Pro point contact tonometer before IVI (T0), 1 minute (T1), 30 minutes (T2), 60 minutes (T3) after IVI. Measurement of IOP was performed during the first injection. Mathematical and statistical processing of the obtained data was performed using the statistical program SPSS 23.3. A p < 0.05 value was considered statistically significant. Results. In the two groups, the dynamic changes of IOP was the same: IVI increased immediately, returned to normal within 30–60 minutes. Mean IOP values before the start of treatment were comparable in the two groups (p = 0.89), 1 min after IVI anti-VEGF drugs, the mean IOP was significantly higher in 2nd group compared to 1st group (p = 0.002), 30 min and 60 min after IVI IOP in 1st and 2st groups were not differ statistically (p = 0.36, p = 0.68, respectively). The number of patients with IOP 1 min after IVI more than 35 mm Hg in 2nd group was 75 %, while in 1st group – 50 %. Conclusions. In this study, we compared for the first time the dynamic changes of IOP after IVI of aflibercept and brolucizumab. To further study it is necessary to analyze longterm results in a larger sample of patients. Keywords: brolucizumab, aflibercept, intraocular pressure
Evaluation of the effect of the rate and completeness of intra- and subretinal fluid resorption on the dynamics of visual functions in neovascular age-related macular degeneration during therapy with brolucizumab
Authors:   OOO «Medstandart», Irkutsk, Novolodskiy A.I. , Burlakova E.V. ,   OOO «Medstandart», Irkutsk, Burii V.V. ,   OOO «Medstandart», Irkutsk
Published: April 2023

Currently, there is insufficient data in the literature on the effect of the rate of regression of sub- and intraretinal fluid on the dynamics of maximum corrected visual acuity in the treatment of neovascular age-related macular degeneration (nAMD) against the background of the use of brolucizumab. In the course of the study, it was found that rapid resorption of intraretinal and subretinal fluid does not affect the functional results of treatment, and the severity of retinal edema at the start of therapy affects the timing of reducing the thickness of the central retinal zone. Keywords: neovascular age-related macular degeneration, brolucizumab, the rate and completeness of fluid regression
Cyst of the orbit, ptosis of the upper eyelid caused by previously performed vitreoretinal surgery: clinical case
Authors:   State Autonomous Healthcare Institution of the Kemerovo Region «Kuzzbas Regional Clinical Hospital named after S.V. Belyaev», Kemerovo, Russia, Yanchenko T.V. , Tretyak E.A. ,   State Autonomous Healthcare Institution of the Kemerovo Region «Kuzzbas Regional Clinical Hospital named after S.V. Belyaev», Kemerovo, Russia
Published: April 2023

Purpose. To present a clinical case of detection of a tamponing substance in the anterior parts of the orbit and retrobulbar tissue, upper eyelid tissues, subconjunctivally after vitreoretinal surgery. Material and methods. In the Kuzbass Regional Clinical Hospital named after S.V. Belyaev, under the supervision of 2019–2022, there was a patient who revealed elements of a tamponing substance in the tissues of the orbit, conjunctiva, upper eyelid after surgical treatment for regmatogenic retinal detachment. Standard ophthalmological examination, ultrasound examinations, magnetic resonance imaging were performed. Results. As a result of reconstructive plastic surgery, the anatomical position of the upper eyelid and orbital tissues was restored. Conclusion. In the presented clinical case, options for the migration of silicone oil into the structures of the accessory apparatus of the eye and orbit, which caused additional surgical interventions, are described. Keywords: vitreoretinal surgery, tamponing agent, silicone oil, cyst of the orbit, ptosis of the upper eyelid
Surgical treatment of eye contusion combined with cyclodialysis: а сase report
Authors:   Eye Microsurgery Institution named by academician S. Fyodorov, Cheboksary, Russian Federation, Zotov V.V.
Published: April 2023

Background. Eye injuries are still one of the main causes of vision loss and disability today. Injuries of the organ of vision are more likely to affect people of working age, which actualizes the significance of this pathology. Case presentation. A 32-year-old man experienced a retinal detachment in his left eye, complicated by traumatic cyclodialysis, choroid detachment, vitreous hemorrhage, aphakia, and corneal scar. His corrected distance visual acuity was 0.005 and intraocular pressure less 10.0 mmHg. We performed posterior trepanation of the sclera, anterior chamber reconstruction, corneal suture repositioning, threeport 25G-vitrectomy with removal of hemophthalmus, endolaser coagulation of the retina followed by tamponade of the vitreal cavity with silicone oil. 2 months later we performed trepanation of the sclera with drainage of the supraciliary fluid and the introduction of a blunt cannula into the supraciliary space of platelet-rich plasma – autologous conditioned plasma (ACP). Anterior segment optical coherence tomography and ultrasonic biomicroscopy revealed reattachment of the ciliary body to the sclera spur. In the end his corrected distance visual acuity was 0.4 and intraocular pressure 20 mmHg. Conclusions. The use of autologous conditioned plasma in the surgical treatment of cyclodialysis is an effective and safe method of treatment and allows achieve reattachment of the ciliary body to the sclera spur. The long-term effectiveness of the method can be assessed by increasing the observation period and the number of interventions. Keywords: cyclodialysis; trauma; autologous conditioned plasma
Мorphofunctional parameters of the central zone of the retina of patients after surgical treatment of regmatogenous retinal detachment complicated by macular hole
Authors:   Institute of Advanced Training of Physicians N.I. Pirogov National Medical Surgical Center, Moscow, Vaganova E.E. , Fayzrakhmanov R.R. ,   Institute of Advanced Training of Physicians N.I. Pirogov National Medical Surgical Center, Moscow,   N.I. Pirogov National Medical Surgical Center, Moscow, Sekhina O.L. ,   Institute of Advanced Training of Physicians N.I. Pirogov National Medical Surgical Center, Moscow, Klev V.S. ,   N.I. Pirogov National Medical Surgical Center, Moscow
Published: April 2023

Rhegmatogenous retinal detachment, complicated by macular hole often leads to severe visual impairment. The aim of the research was to study the effectiveness of surgical treatment of patients with retinal detachment complicated by macular rupture of the РVR В-C, depending on the method of subretinal fluid drainage. We studied the data of 18 patients (18 eyes), which were divided into 2 groups depending on the presence of a hole in the periphery of the retina. Patients of the 1st group underwent surgical treatment with drainage of the subretinal fluid through the central hole, patients of the 2nd group – with drainage through the primary peripheral hole. Visual acuity, microperimetry, and optical coherence tomography were used to assess the anatomical and functional outcome. Based on the analysis of the results of the study, it can be concluded that the peripheral method of drainage of subretinal fluid using a perfluoroorganic compound is better. This technique leads to a higher functional and anatomical result. Keywords: retinal detаchment, macular hole, subretinal fluid
Writing of Natalia Mikhaleva-Saya: a variety of themes and features of the lyrical subject
Authors: Павлова О.К. , Лукина К.В.
Published: April 2023

Данная статья посвящена творчеству народного писателя Якутии Н. В. Михалевой-Сайа. Цель статьи заключается в анализе разновидностей тем и особенностей лирического субъекта ее поэзии. Сайа в своих стихах затрагивает разнообразные темы: патриотизм, любовь к родине, природа, счастливая любовь, ожидание любви и др. Стихотворения отражают настоящую жизнь: чувство, испытываемое человеком от любви, счастья, переживания разлуки, привязанность к родным местам, красоту природы и др. Кроме этого, в стихотворениях поэтессы мы находим концепты: свободы, творчества, любви к родине и др.
Traditions of Oriental literature and folklore in the poem "Kyissai Ibrahim Adham" by the Tatar poet of the 19th century Gabdeljabbar Kandaly
Authors: Сафиуллина Р.Ф.
Published: April 2023

В данной статье рассматривается влияние литературы мусульманского Востока на татарскую литературу. Межлитературные связи мусульманских тюркоязычных народов стали особенно выраженными с распространением ислама в Средней Азии, Сибири, на Урале, в Поволжье, на Кавказе, в Крыму. В качестве постановки вопроса высказывается мнение о том, что ислам привнес в татарскую литературу и в народное творчество новые темы, жанры, образы и символы. Автор приходит к мнению о том, что принятие новой религии обеспечило письменную фиксацию литературы и фольклора. В статье анализируется поэма XIX в. «Кыйссаи Ибрахим Адхам» татарского поэта Габдельджаббара Кандалыя (1797–1860), ставшая классическим образцом религиозно-дидактической и суфийской поэзии. Поэма создана в традициях «Пэнднамэ» ‘Аттара и других суфийских поэтов, освещает некоторые эпизоды жизни реальной исторической личности – суфийского шейха Ибрахима ибн Адхама. Выполнен сравнительный анализ татарской поэмы об Ибрахиме Адхаме и турецкого народного дастана «Ибрахим Адхам». В результате анализа автор статьи приходит к выводу о том, что поэма «Кыйссаи Ибрахим Адхам» Г. Кандалыя, сохранив традиционные мотивы и идеи религиозно-дидактических произведений литературы Востока, стала самостоятельным, оригинальным произведением на татарском языке.
The verbs of causation of the beginning of existence in the poetic text of Kulakovsky’s Ottoku oluk algyha (“Blessing of the middle generation”)
Authors: Сивцева Н.А.
Published: April 2023

Статья посвящена исследованию глаголов каузации начала существования в произведении А. Е. Кулаковского «Оттоку олук алгыһа» («Благословение среднего поколения»). Определен состав глаголов каузации начала существования в структуре данного поэтического текста, проанализированы их значение, использованное в определенном контексте. Исследование базируется на принципах функционально-семантического подхода, позволяющего отобразить целостную организацию универсальных семантических категорий с определенным содержанием и средствами выражения. В исследовании применены структурный анализ, позволяющий представить наиболее подробную характеристику отношений между компонентами языковых явлений; контекстное описание с приемами наблюдения, обобщения. Описание примеров осуществлено на основе глоссирования как метода репрезентации текстов. Обращение к тексту А. Е. Кулаковского, основоположника якутской художественной литературы, позволяет выявить особенности в использовании языковых средств в ранней зарождающейся литературной поэзии, отличной от традиции устного народного творчества. В статье впервые подвергаются анализу глаголы каузации начала существования, изложенные в указанном произведении.
Synthesis of potent antileukemic quinazoline-thiohydantoin fused heterocycles enabled by metal-free domino reaction
Authors: Kersting Lena , Zippel Christoph , Herrmann Lars , Seo Ean-Jeong , Saeed Mohamed E.M. , Gaube Angelika , Tailor Dhanir , Dheeraj Arpit , Malhotra Sanjay V. , Muehlich Susanne , Efferth Thomas , Tsogoeva Svetlana B.
Published: April 2023

Heterocyclic compounds play a central role in drug development research and are contained in most pharmaceuticals on the market. Quinazoline and thiohydantoin are heterocycles and hold very prominent positions due to their diverse pharmacological profiles. While quinazolines fused with other heterocyclic units are already found in various clinically used pharmaceuticals, fused quinazoline-thiohydantoin frameworks have yet to be described since no synthetic approaches have been reported so far. Here, we present the development of a highly efficient, operationally simple, and fully metal-free three-step domino reaction towards fused heterocycles using readily available starting materials. Merging the novel three-step domino reaction and a dehydrogenation step in one pot leads to atom-economical, expeditious, and high-yielding (up to 92%) organic synthesis of unprecedented quinazoline-thiohydantoin fused frameworks. This new class of fused heterocycles features high in vitro activities and selectivities against multidrug-resistant P glycoprotein-overexpressing CEM/ADR5000 leukemia cells (IC50 down to 0.127 µM). It exceeds the potency of the clinical reference drug doxorubicin (IC50 23.27 µM). Furthermore, nuclear localization of Myocardin-related transcription factor A (MRTF-A, a.k.a. Megakaryoblastic Leukemia MKL1) as a tumor biomarker and driver of tumor resistance was decreased upon administration of quinazoline-thiohydantoin fused heterocycles. The developed straightforward synthetic approach enables the easy and direct formation of model drugs to overcome multidrug resistance in leukemia cells.
New botulinum neurotoxin constructs for treatment of chronic pain
Authors: Leese Charlotte , Christmas Claire , Mészáros Judit , Ward Stephanie , Maiaru Maria , Hunt Stephen P , Davletov Bazbek
Published: April 2023

Chronic pain affects one in five people across human societies, with few therapeutic options available. Botulinum neurotoxin (BoNT) can provide long-lasting pain relief by inhibiting local release of neuropeptides and neurotransmitters, but its highly paralytic nature has limited its analgesic potential. Recent advances in protein engineering have raised the possibility of synthesising non-paralysing botulinum molecules for translation to pain sufferers. However, the synthesis of these molecules, via several synthetic steps, has been challenging. Here, we describe a simple platform for safe production of botulinum molecules for treating nerve injury–induced pain. We produced two versions of isopeptide-bonded BoNT from separate botulinum parts using an isopeptide bonding system. Although both molecules cleaved their natural substrate, SNAP25, in sensory neurons, the structurally elongated iBoNT did not cause motor deficit in rats. We show that the non-paralytic elongated iBoNT targets specific cutaneous nerve fibres and provides sustained pain relief in a rat nerve injury model. Our results demonstrate that novel botulinum molecules can be produced in a simple and safe manner and be useful for treating neuropathic pain.
Impact of social media on tourism industry in india
Authors: Rethesh Kumar A. , Krishnamoorthy V. , Somasundaram R.
Published: April 2023

Tourism is a great source of revenue for any country, and the media plays a critical role in promoting tourism in many ways, including information search, decision-making behaviors, and focusing on best practices for interacting with customers. Educational tourism is one of the fastest-growing sectors of travel and tourism, but it often goes overlooked by tourism professionals and marketers. The emergence of social media has caused a significant shift in marketing strategies. Individuals, corporations, Non-Governmental Organizations (NGOs), governments, and other organizations can use social media to view, produce, and share information, ideas, career interests, and other forms of expression in digital communities and networks. According to research, social media plays a vital role in promoting educational tourism, which improves and enhances a country's economic, social, political, and cultural life. This study proposes that, for destination visits, the variables of customer perceived value should be examined using the social networking approach.
Digital value chain strategies and its impact on organizational productivity: The mediating role of government digital initiatives to achieve 5 trillion US$ economy by 2025. A case study of select automobile firms in delhi NCR region
Authors: A. V. Nageswara Rao
Published: April 2023

The unprecedented COVID-19 pandemic has severely affected the Automobile sector in the Delhi NCR region with Supply chain disruptive innovations and periodic travel restrictions imposed by the government. The present study investigates the influence of the digital value chain on organisational productivity. The study analyses the data collected from Logistics and Supply chain managers working in allied areas of value chain operations in the automobile sector. The target respondents selected for the study are 200, and purposeful sampling is used to identify the target respondents with expertise in the areas of supply chain and marketing. Partial least squares regression is used to analyse the collected data and establish relationships among the variables and explanatory variables. The study contributes to the understanding of value chain strategies and their significance in enhancing organisational productivity in the automobile sector.
Methodology of estimation the parameters permissible values of the aerodynamic and inertial asymmetry of the martian probe
Authors: Bakry I.
Published: April 2023

A technique for estimating small permissible values of the parameters of the aerodynamic and inertial asymmetry of an unguided space probe in the rarefied layers of the Martian atmosphere is considered. The desired estimate is presented as a region on the plane of asymmetry parameters. It is assumed that the spatial angle of attack during descent in the Martian atmosphere of the space probe takes small values. In this work, the region of admissible values of the asymmetry parameters of the space probe is determined, which ensures a non-resonant uncontrolled descent in the Martian atmosphere. In this case, the maximum values of the small aerodynamic and small inertial asymmetries of the space probe are calculated, at which its angular velocity does not reach resonance values. An algorithm is proposed for determining the region of admissible values of space probe asymmetry parameters, which ensures non-resonant motion in the Martian atmosphere. The results of numerical simulation confirm the reliability of the restrictions determined using the proposed method and imposed on the region of permissible values of the parameters of aerodynamic and inertial asymmetries.
Optimization of the launch profile of geostationary spacecraft with electric propulsion system using Falcon-9 launch vehicle
Authors: Paing Soe Thu Oo
Published: April 2023

A combined flight profile is being considered, in which the Falcon 9 launch vehicle launches the spacecraft into elliptical intermediate orbit from the Cape Canaveral launch site. In the process of analyzing the problem, the value of the height of the perigee and the inclination of the intermediate orbit are fixed, and the height of the apogee of the intermediate orbit varies. After separation from the last stage of the launch vehicle, the spacecraft carries out transfer to geostationary orbit using electric propulsion system. At the stage of insertion spacecraft from intermediate orbit to geostationary orbit using electric propulsion system, the problem of minimizing the mass of the propellant, multi-revolutionary transfer is considered. The number of revolution and the height of the apogee of the intermediate orbit vary in order to analyze the effect of these parameters on the duration of the transfer and the delivered mass of the spacecraft into geostationary orbit. The main purpose of this paper is to calculate the optimal values of the apogee height of the intermediate orbit and the optimal number of revolution that ensure the delivery of the maximum mass of the spacecraft to the geostationary orbit in a given time delta(t)*. To solve the optimization problem, the Pontryagin maximum principle is applied. After apply ing the maximum principle, the optimization problem is reduced to solving the boundary value problem, which is solved by the continuation method by parameter. The paper presents the results of the optimization problem of multi-revolutionary transfer and analysis of the energy characteristics of combined flight profile for insertion of spacecraft into geostationary orbit.
VALIDITAS MEDIA EDUKASI THE FISH STRUGGLE GAME UNTUK PEMBELAJARAN KARAKTER CINTA LINGKUNGAN
Authors: Yazid Khairul , Muntamah Lilik , Fahmi Ma’arif Amanda
Published: April 2023

Tujuan penelitian ini adalah untuk menghasilkan media edukasi yang valid secara empiris pada pembelajaran Biologi materi pelestarian lingkungan bagi peserta didik kelas X SMA/MA. Penelitian pengembangan ini mengacu pada model ADDIE yang telah dilaksanakan pada Bulan Maret hingga November 2020 di MAN 1 Jembrana. Pengembangan media yaitu tahapan analisis, perancangan, pengembangan, implementasi, dan evaluasi. Sasaran penelitian ini adalah tersedianya media edukasi untuk menanamkan karakter cinta lingkungan pada peserta didik yang valid secara empiris. Validator media edukasi yang dikembangkan terdiri dari satu orang dosen ahli media pembelajaran dan dua orang guru Biologi. Aspek validasi media meliputi kelayakan isi, tampilan, dan bahasa. Data dianalisis secara deskriptif kuantitatif. Hasil penelitian menunjukan bahwa aspek kelayakan isi mendapat rata-rata skor 3,5 (baik), kelayakan bahasa 3,6 (sangat baik), dan kelayakan tampilan 3,8 (sangat baik). Penilaian keseluruhan The Fish Struggle Game mendapat persentase sebesar 92% dari ketiga validator dan tergolong kategori sangat layak sebagai media edukasi penanaman karakter cinta lingkungan. Simpulan penelitian ini adalah media edukasi The Fish Struggle Game sangat layak dijadikan media pembelajaran karakter cinta lingkungan.
Corporate reporting and its role in Business Management
Authors: Chaikovskaya L. А.
Published: April 2023

The purpose of the study is to reveal the features and role of corporate reporting in business management. Ideas for its improvement are connected with the developing economic reality and are aimed at meeting the needs of an ever wider audience of interested parties (stakeholders).

   The article deals with topical issues related to the existing structure of corporate reporting aimed at disseminating the necessary amount of data among stakeholders, as well as the features of integrated reporting, which seeks to combine various components of corporate information. The methodological basis of the study was a system-functional and economic-statistical analysis, comparison. Based on the results of the work, it was concluded that corporate reporting is an important means by which companies communicate with stakeholders in management activities, incl. In fulfillment of their obligations. The results of the study can be used in the collection of data for the preparation and formation of corporate reporting of organizations.
Economic Justification of tax Planning
Authors: Polyakova M. A. , Nosov A. V.
Published: April 2023

The application of tax planning by an economic entity will make it possible to release part of the funds from financial (including tax) liabilities and effectively use them in the reproduction process for modernization, reconstruction, improvement of technical conditions for the production of goods, works and services. Every structure of a successful business strives for profitable production, therefore tax optimization, methods and schemes of its application are topical issues. In the context of an annual increase in the tax burden, optimization for entrepreneurial activity is interesting not only for the existing companies, but also for novice businessmen and start-ups.

   The purpose of the study is to substantiate and develop practical recommendations for the implementation of tax planning.

   To achieve it, the following tasks and objectives were set: to study and generalize the views of Russian scientists in modern economic conditions; to develop approaches to improving the mechanism of tax optimization in order to perform the functions assigned to it, and above all, to influence the financial conditions of an economic entity through the possibility of tax optimization provided by legislation. In the course of the work, the following methods of classification were used: abstract-logical, monographic, analytical, logical approach, comparison and generalization, etc.

   The methodological and theoretical basis for the study was the works of representatives of Russian science, regulatory and legislative acts of the Russian Federation regulating the functioning of the tax system; official publications, as well as materials of scientific and practical conferences. The obtained results contribute to the identification of ways to improve the mechanism of tax planning by business entities.
Monitoring of Material consumption for the Production of goods by industrial Enterprises
Authors: Mizikovsky I. E.
Published: April 2023

The article is dedicated to the problem of ensuring transparency of the information space in terms of the expenditure of material resources in the flow of value creation by an industrial enterprise. The objective need to transform the existing paradigm of corporate management of material resources involved in the production is motivated by global macroeconomic changes in market conditions, routing of goods, access to financial services, etc.

   Since it has been revealed that the planning and control tools used at the studied enterprises for the use of materials in the main production are insufficient for economical, rational and balanced management of the latter the authors have set an objective and purpose of the study to improve these tools, through the planning and control of the consumption of materials involved in the main production, using specified norms of their expenditure. In the course of the research, project and process approaches were used; the methods of preliminary, problem-oriented and complex types of analysis, observation, generalization, systematization, verification, as well as graphical visualization.

   It has been proved that the complex use of specified norms is one of the key elements of the information and instrumental or tool space formation for the productive implementation of the functions of planning and control of the expenditure and consumption of the materials; making operational decisions and developing long-term strategies for their effective use in the adding value flow.
Afrochoteños del Juncal: una etnografía sobre la identidad individual y colectiva
Authors: Gavilanes Verónica , Vera Toscano María Pía
Published: April 2023

Las dinámicas de la comunidad afroecuatoriana del Juncal, en el valle del Chota, se caracterizan por tener una configuración particular del espacio doméstico y público, además de estrechas relaciones de solidaridad. Estas características son aspectos fundamentales de la identidad colectiva de sus habitantes. Sin embargo, un proceso constante de migración a la ciudad ha implicado la introducción de elementos identitarios de origen externo que se ponen en tensión con la identidad colectiva. Este artículo, presenta una etnografía que muestra, por un lado, las dinámicas comunitarias particulares que configuran la identidad colectiva de este grupo; por otro, pretende explicar cómo los cambios experimentados en la identidad individual durante el

proceso de migración a la ciudad influyen en las relaciones comunitarias. Esto con la finalidad de analizar las maneras en que interactúan los elementos identitarios colectivos e individuales en la construcción de la identidad del yo de los afrochoteños del Juncal.
Mujeres a través del ritual: jubilación femenina, transición y negociaciones en torno a la identidad y el rol social
Authors: Argüello Valeria , Páez Carolina
Published: April 2023

Este artículo aborda la jubilación en el caso femenino como una experiencia de cambio. Desde un enfoque ritual, se analizan las etapas del proceso jubilatorio, las cuales se clasifican como separación, limen y agregación. La información empírica se recopiló en tres sitios de reunión de personas jubiladas en Quito y Rumiñahui (Ecuador). A lo largo del periodo septiembre 2017- marzo 2019 se estableció comunicación con 30 mujeres de clase media en etapas previas y post jubilatorias, se entabló conversaciones y se participó en las actividades realizadas en los sitios de reunión de personas jubiladas. El hallazgo principal es la identificación de etapas dentro del proceso jubilatorio: 1) separación, definida por la decisión de jubilarse; 2) limen, manifestado en la ambigüedad del rol e identidad social de las mujeres en proceso de jubilación; 3) agregación, como un momento de búsqueda del rol y negociación de su lugar social.