bluuebunny/crossref_metadata_2025 huggingface dataset:
Laboratory-Scale Investigation on Shear Behavior of Non-Persistent Joints and Joint Infill Using Lattice-Spring-Based Synthetic Rock Mass Model
Authors: Al-E’Bayat Mariam , Sherizadeh Taghi , Guner Dogukan
Published: January 2023

Discontinuities mainly control the mechanical behavior of rock mass and cause a significant reduction in the rock mass strength. Joint persistency and joint infill conditions are considered the most significant joint parameters that control the mechanical response of rock mass. In this study, numerical and statistical analyses were performed on pre-cracked specimens with two flaws to investigate the effect of joint persistence parameters on shear strength. In addition, an extensive study was conducted to explore the effect of infilled mineral strength, infill thickness, and infill wall roughness on shear strength. The Lattice-Spring-Based Synthetic Rock Mass (LS-SRM) approach was utilized to perform the numerical models. The results showed that the tensile crack propagation is limited at higher normal stresses as tensile damage is largely suppressed. The increases in rock bridge angle slightly increased the shear strength and caused a change in the failure mechanisms of the rock bridge from tensile to shearing. The results of the models with infilled minerals revealed that infilled minerals mainly controlled the shear strength of specimens when the infill thickness was 4.0 mm or greater. The infill wall roughness had no apparent effect on the shear strength. In contrast, it governed the failure mechanisms; cracks initiated at the asperity of the rough filling wall and propagated through the hosted rock mass.
Acknowledgment to the Reviewers of Geosciences in 2022
Authors:   Geosciences Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Assessing the Quality of the Leica BLK2GO Mobile Laser Scanner versus the Focus 3D S120 Static Terrestrial Laser Scanner for a Preliminary Study of Garden Digital Surveying
Authors: Del Duca Graziella , Machado Carol
Published: January 2023

Gardens play a key role in the definition of the cultural landscape since they reflect the culture, identity, and history of a people. They also contribute to the ecological balance of the city. Despite the fact that gardens have an historic and social value, they are not protected as much as the rest of the existing heritage, such as architecture and archaeological sites. While methods of built-heritage mapping and monitoring are increasing and constantly improving to reduce built-heritage loss and the severe impact of natural disasters, the documentation and survey techniques for gardens are often antiquated. In addition, inventories are typically made by non-updated/updateable reports, and they are rarely in digital format or in 3D. This paper presents the results of a comprehensive study on the latest technology for laser scanning in gardens. We compared static terrestrial laser scanning and mobile laser scanning point clouds generated by the Focus 3D S120 and the Leica BLK2GO, respectively, to evaluate their quality for documentation, estimate tree attributes, and terrain morphology. The evaluation is based on visual observation, C2C comparisons, and terrain information extraction capabilities, i.e., M3C2 comparisons for topography, DTM generation, and contour lines. Both methods produced useful outcomes for the scope of the research within their limitations. Terrestrial laser scanning is still the method that offers accurate point clouds with a higher point density and less noise. However, the more recent mobile laser scanning is able to survey in less time, significantly reducing the costs for site activities, data post-production, and registration. Both methods have their own restrictions that are amplified by site features, mainly the lack of plans for the geometric alignment of scans and the simultaneous location and mapping (SLAM) process. We offer a critical description of the issues related to the functionality of the two sensors, such as the operative range limit, light dependency, scanning time, point cloud completeness and size, and noise level.
Cross-Cultural Adaptation and Psychometric Properties of the Spanish Version of the OPQOL-Brief
Authors: Perogil-Barragán Natalia , Gomez-Paniagua Santiago , Rojo-Ramos Jorge , González-Becerra María José , Barrios-Fernández Sabina , Gianikellis Konstantinos , Castillo-Paredes Antonio , Carvajal-Gil Julián , Muñoz-Bermejo Laura
Published: January 2023

Background: Ageing and its consequences on quality of life is one of the main issues to be addressed by public organizations; therefore the development of tools for its evaluation is a priority issue to orientate lines of action. Therefore, the objective of this research is to carry out cross-cultural adaptation and present the psychometric properties of the Spanish version of the Older People’s Quality of Life Questionnaire-Brief (OPQOL-Brief). Methods: a cross-cultural adaptation was carried out together with a process of translation and back-translation of the scale. The OPQOL-Brief and a sociodemographic questionnaire were administered to 120 older adults aged over 65 from a healthcare setting in the region of Extremadura. Results: the exploratory analysis revealed a factor structure through a matrix of polychoric correlations divided in two intercorrelated factors, consisting of 12 items and with excellent sample adequacy indices (KMO = 0.846’; Bartlett test = 1268.1; p = 0.000). Then, the confirmatory factor analysis established the definitive model with exceptional goodness-of-fit indices (NNFI = 0.99; CFI = 0.99; CMIN/DF = 0.96; Ρ (χ2) = 0.22; RMSEA = 0.037 and RMSR = 0.040). Finally, Cronbach’s alpha and McDonald’s omega for internal consistency reported good values of 0.830 and 0.851, respectively. Conclusion: our findings show that the OPQOL-Brief exhibits a solution with 12 elements and related constructs, providing stable goodness-of-fit indicators as well as good and remarkable consistency ratings.
Erosion of Granite Red Soil Slope and Processes of Subsurface Flow Generation, Prediction, and Simulation
Authors: Ma Yichun , Li Zhongwu , Tian Liang , Yang Yifan , Li Wenqing , He Zijuan , Nie Xiaodong , Liu Yaojun
Published: January 2023

A deeper understanding of the rainfall–flow processes can improve the knowledge of the rain-driven erosional processes in coarse-textured agricultural soil. In this study, on the red soil slope farmland developed from weathered granite, a simulated rainfall experiment was conducted to study the characteristics of rainfall redistribution, the processes of surface–subsurface flow generation and prediction, and sediment production. Rainfalls with three intensities of 45, 90, and 135 mm h−1 with a duration of 90 min were applied to the weathered granite red soil with the slope gradient of 10°. Under 45 mm h−1 rainfall intensity, the output of rainwater was composed by subsurface flow and bottom penetration, accounting for 35.80% and 39.01% of total rainfall, respectively. When the rainfall intensities increased to 90 and 135 mm h−1, the surface flow became the main output of rainwater, accounting for 83.94% and 92.42%, respectively. Coarsened soil exhibited strong infiltration-promoting but poor water-storage capacities under light rainfalls. With an increased rainfall intensity, the surface flow coefficient increased from 19.87% to 92.42%, while the amount of subsurface flow and bottom penetration decreased by 1.3 and 6.2 L, respectively. For sediment production, the sediment concentration was raised from 1.39 to 7.70 g L−1, and D10, D50, and D90 increased by 1.50, 1.83, and 1.40 times, respectively. The content of coarse particles (>1 mm) in surface soil increased by 12%, while the content of fine particles (<0.5 mm) decreased by 9.6%. Under strong rainfalls, severe soil and water loss, coarsening soil surface, and large loss of fine particles became major problems. During rainfall, the subsurface flow and bottom penetration could be predicted well through quadratic equations of rainfall time, which transformed into time-dependent exponential functions after rainfall. The results provide a theoretical basis and data reference for soil erosion prevention and water management in coarse-textured agricultural lands.
Analysis of 222Rn Surface Concentrations in the Basque Country (Spain): A Case Study of Heat Waves
Authors: Alegría Natalia , Hernández-Ceballos Miguel Ángel , Cinelli Giorgia , Peñalva Igor , Muñoz Jose Miguel
Published: January 2023

The objective of this study was to characterize radon concentrations registered in the Radiological Surveillance Network of the Basque country in relation to local meteorological parameters, and to determine its behaviour under heatwave events. For this purpose, radon measurements and meteorological parameters from June 2012 to June 2015 were analysed at two sites, Bilbao and Vitoria (northern Spain), in a region characterized by complex orography, causing large temporal and spatial variability in meteorological conditions. Yearly, seasonal, and diurnal cycle differences and similarities were investigated at both sites. The temporal evolution of radon concentration was analysed at both sites during the two heatwave periods officially identified by the State Meteorological Agency (8–11 August 2012 and 17–23 August 2012). The analysis revealed two different patterns of radon concentrations, in terms of both time and intensity, under this synoptic pattern, making it also possible to identify regional transport channels of radon concentrations between the two sites. This set of results evidences the adequate position of both stations to represent the spatial and temporal evolution of radiological variables continuously in this region.
Use of Preliminary Exposure Reduction Practices or Laundering to Mitigate Polycyclic Aromatic Hydrocarbon Contamination on Firefighter Personal Protective Equipment Ensembles
Authors: Wilkinson Andrea F. , Fent Kenneth W. , Mayer Alexander C. , Chen I-Chen , Kesler Richard M. , Kerber Steve , Smith Denise L. , Horn Gavin P.
Published: January 2023

Chronic health risks associated with firefighting continue to be documented and studied, however, the complexity of occupational exposures and the relationship between occupational exposure and contaminated personal protective equipment (PPE) remains unknown. Recent work has revealed that common PPE cleaning practices, which are becoming increasingly more common in the fire service, are not effective in removing certain contaminants, such as polycyclic aromatic hydrocarbons (PAHs), from PPE. To better understand the relationship between contaminated firefighter PPE and potential exposure to PAHs, and to gain further understanding of the efficacy of cleaning practices, we used a standardized fire exposure simulator that created repeatable conditions and measured PPE surface contamination levels via wipe sampling and filters attached to firefighter gear worn by standing mannequins. This study examined the effects of repeated (40 cycles) PPE cleaning (laundering and on-scene preliminary exposure reduction (PER) techniques) and repeated exposures on PAH concentration on different surfaces. Further exploration included examination of contamination breakthrough of turnout jackets (comparing outer shell and interior liner) and evaluation of off-gassing PAHs from used gear after different cleaning treatments. When compared by jacket closure type (zipper and hook and dee), total PAH concentration wiped from gear after exposure and cleanings showed no significant differences. Regression analysis indicated that there was no effect of repeated exposures on PAH contamination levels (all sampling sites combined; before fire 10, 20, and 40; after fire 1, 10, 20, and 40; p-value > 0.05). Both laundering and on-scene PER significantly reduced contamination levels on the exterior pants and helmets and were effective at reducing PAH contamination. The jacket outer shell had significantly higher PAH contamination than the jacket liner. Both laundering and wet soap PER methods (post-fire) are effective in reducing surface contamination and appear to prevent accumulation of contamination after repeated exposures. Semi-volatile PAHs deep within the fibers of bulky PPE are not effectively reduced via PER or machine laundering, therefore, permitting continued off-gassing of these compounds. Further research is needed to identify the most effective laundering methods for firefighter turnout gear that considers the broad spectrum of common contaminants.
Optimists and Realists: A Latent Class Analysis of Students Graduating from High School during COVID-19 and Impacts on Affect and Well-Being
Authors: Zdravkovic Ana , Goldstein Abby L.
Published: January 2023

The Novel Coronavirus Disease (COVID-19) pandemic has had profound effects on physical and mental health worldwide. Students transitioning out of high school were uniquely impacted at the onset of the pandemic, having missed the opportunity to properly mark the end of their final year in the K-12 school system. The adverse effects of this loss on this population are still unknown. The purpose of the current study was to examine stress, wellbeing, and affect in a sample of 168 students (N = 168; Mage = 17.0, SD = 0.46; 60% female; 40% male) who were completing their final year of high school during the early stages of the pandemic when emergency stay-at-home orders were in place. Participants completed an online survey assessing the impact of COVID-19 on their life satisfaction (pre-COVID19, during COVID-19, and anticipated five years from now), stress, positive affect, and negative affect. Latent class analysis (LCA) was used to create classes of participants based on their responses to the pandemic. A two-subgroup solution provided the best model for the life satisfaction outcome variable. Subgroup 1, optimists, comprised 24% (N = 40) of the sample and reported high life satisfaction ratings one year prior to COVID-19 and a slight decrease in life satisfaction during COVID-19, and they anticipated an increase in life satisfaction 5 years from now. This group was characterized by low stress, low negative affect, and high positive affect during the pandemic. Subgroup 2, realists, comprised 76% of the population (N = 128) and experienced similarly high retrospective ratings of pre-COVID life satisfaction but a larger decrease in life satisfaction during the pandemic and a smaller increase in five years. The realist group was characterized by low positive affect, high stress, and high negative affect during the pandemic. The findings suggest that during the pandemic, certain subsamples of adolescents had greater difficulty in managing this transitional period and experienced changes in mood and well-being (i.e., affect, stress) as compared to other adolescents (i.e., optimists). Future research should investigate the characteristics and coping mechanisms that are instrumental for increasing life satisfaction and positive affect while lowering stress in this population.
Herpes Zoster Risk in Patients with Rheumatoid Arthritis and Its Association with Medications Used
Authors: Dlamini Sithembiso Tiyandza , Htet Kyaw Moe , Theint Ei Chue Chue , Mayadilanuari Aerrosa Murenda , Li Wei-Ming , Tung Yi-Ching , Tu Hung-Pin
Published: January 2023

Rheumatoid arthritis (RA) was associated with the risk of incident herpes zoster (HZ), which might be influenced by medication use by RA patients. We aimed to investigate the association of RA with the risk of incident HZ and how the HZ risk effected by RA medications in CIC RA patients. We conducted an observational study including population-based representative insurance claims data of 19,673 patients with RA and 39,346 matched patients without RA during 1997–2010 from the Taiwan National Health Insurance Research Database; we identified 1651 patients with catastrophic illness-certified (CIC) RA and 11,557 matched patients with non-CIC RA. Exploratory analyses assessed the association between RA/CIC RA and risk of incident HZ and its complications. The association of prescribed medications with HZ risk in CIC RA patients was also estimated. The incidence rates of HZ were higher in CIC RA patients and non-CIC RA than in the matched people without RA (21.95 and 14.03 vs. 7.36 events per 1000 person-years, respectively). The adjusted incidence rate ratio (95% confidence interval (CI)) for HZ was 1.74 (1.65–1.84) in RA patients vs. matched non-RA and 1.65 (1.44–1.89) in CIC RA patients vs. non-CIC RA. For HZ complications, RA had a 2.85-fold higher risk than non-RA, and CIC RA had a 1.78-fold higher risk than non-CIC RA. Moreover, in CIC RA patients, prednisolone use was associated with incident HZ risk compared with prednisolone nonuse (adjusted odds ratio 1.48, 1.08–2.03); prolonged prednisolone use (approximately 5 years) increased the risk (adjusted odds ratio 2.16, 1.46–3.19). Our results suggested that RA was positively associated with HZ risk, particularly in RA patients with prednisolone use.
A Qualitative Evaluation of the Implementation of an Oral Care Program in Home Care Nursing
Authors: Weening-Verbree Lina F. , Schuller Annemarie A. , Zuidema Sytse U. , Hobbelen Johannes S. M.
Published: January 2023

An Oral Care Program (OCP) was implemented in home care nursing teams in a northern province of the Netherlands to improve the oral health and hygiene of older people who make use of formal home care in 2018–2019. The aim of the current study was to evaluate the experiences of the stakeholders involved (older people, home-care nurses and dental hygienists) and to report the experienced impact of OCP, with a qualitative approach. Three dental hygienists, nine home care nurses, and eight older people were interviewed with semi-structured interviews, which were audio recorded, transcribed and analyzed using thematic analysis. The codes derived were grouped into nine main themes. OCP was experienced as mostly positive by all stakeholders involved. The educational part lead to more awareness towards oral care, but should be repeated regularly. Personalized oral care plans for older people were experienced positively, however, obtaining oral care behavior changes appeared to be difficult. Collaboration between dental hygienists and home care nurses lead to a positive experience from both sides The method and intensity of collaboration varied between the teams. To provide better access to oral health care for older people in the community, a long term collaboration between home care nursing teams and dental care professionals in their working area should be established.
Spatial Layout Planning of Urban Emergency Shelter Based on Sustainable Disaster Reduction
Authors: Zhu Wenlong , Xing Houlong , Kang Wenlu
Published: January 2023

An urban emergency shelter provides a place of temporary life and shelter for victims after a disaster. As a very important public service facility, its spatial layout is greatly related to the security of lives and the property of the urban residents. Upholding the concept of sustainable disaster reduction, this study took the central urban area of Xuzhou as an example. Based on the analysis of ArcGIS software, this study analyzed and planned the spatial layout of emergency shelters in Xuzhou and visualized the service area ratio, service population ratio, service capacity ratio, and service overlap rate of each administrative district. Finally, 73 fixed emergency shelters were determined, among which eight were classified as central shelters. At the same time, through consulting the relevant data, it was found that similar problems such as potential safety hazard, blind areas, service overlapping, and mismatch of shelter layout and actual needs also exist in other cities. Finally, in light of the existing problems, relevant suggestions are provided for the adjustment and optimization of the layout of emergency shelters.
Influence of Farm Environment on Asthma during the Life Course: A Population-Based Birth Cohort Study in Northern Finland
Authors: Kantomaa Marko T. , Tolvanen Mimmi , Halonen Miia , Svanes Cecilie , Järvelin Marjo-Riitta , Sebert Sylvain
Published: January 2023

We investigated the influence of a farming environment on asthma at three time points from birth to 46 years using the Northern Finland Birth Cohort 1966 (n = 10,926). The prevalence of asthma was investigated by postal questionnaires at 14, 31 and 46 years of age. Exposure to a farming environment was assessed by a postal questionnaire at birth and at 31 and 46 years of age. Odds ratios (ORs) and their 95% confidence intervals (95% CIs) for the prevalence of asthma were obtained from multinomial logistic regression, stratified by sex. Being born in a farmer family was potentially causally associated with lower risk of asthma in males at 31 years of age (OR 0.56, 95% CI 0.37, 0.85) and in females at 46 years of age (OR 0.64, 95% CI 0.44, 0.95). Working as a farmer was not associated with asthma. Exposure to a farming environment in childhood may have a lifelong impact on developing asthma from birth through young adulthood and until middle age, indicating that ‘immune deviation’ may persist throughout life.
Automatic Detection of Oral Squamous Cell Carcinoma from Histopathological Images of Oral Mucosa Using Deep Convolutional Neural Network
Authors: Das Madhusmita , Dash Rasmita , Mishra Sambit Kumar
Published: January 2023

Worldwide, oral cancer is the sixth most common type of cancer. India is in 2nd position, with the highest number of oral cancer patients. To the population of oral cancer patients, India contributes to almost one-third of the total count. Among several types of oral cancer, the most common and dominant one is oral squamous cell carcinoma (OSCC). The major reason for oral cancer is tobacco consumption, excessive alcohol consumption, unhygienic mouth condition, betel quid eating, viral infection (namely human papillomavirus), etc. The early detection of oral cancer type OSCC, in its preliminary stage, gives more chances for better treatment and proper therapy. In this paper, author proposes a convolutional neural network model, for the automatic and early detection of OSCC, and for experimental purposes, histopathological oral cancer images are considered. The proposed model is compared and analyzed with state-of-the-art deep learning models like VGG16, VGG19, Alexnet, ResNet50, ResNet101, Mobile Net and Inception Net. The proposed model achieved a cross-validation accuracy of 97.82%, which indicates the suitability of the proposed approach for the automatic classification of oral cancer data.
Loneliness and Psychosocial Resources among Indigenous and Afro-Descendant Older People in Rural Areas of Chile
Authors: Gallardo-Peralta Lorena P. , Gálvez-Nieto José Luis , Fernández-Dávila Paula , Veloso-Besio Constanza
Published: January 2023

(1) Background: loneliness is a problem that becomes increasingly acute in old age, with greater repercussions among socially disadvantaged groups such as indigenous and Afro-descendant older adults. The aim of this research is to analyze the psychosocial variables related to loneliness in old age. (2) Methods: a multi-ethnic sample was involved, with the participation of eight indigenous peoples and Afro-descendant tribal people (n = 1.348). Various gerontological scales previously validated among the Chilean population (De Jong Gierveld Loneliness Scale, Brief Resilient Coping Scale, Health Problems Questionnaire, and Family APGAR questionnaire) and a model are contrasted, establishing the relationship between psychosocial variables and loneliness. (3) Results: Structural equation modeling (SEM) showed the existence of indirect relationships between health problems, via family functioning and resilience, and loneliness. Resilience and family functioning were directly related to loneliness (WLSMV-χ2 (df = 345) = 875.106, p < 0.001; CFI = 0.992; TLI = 0.991; RMSEA = 0.034 [C.I. 90% = 0.031–0.037]). (4) Conclusions: loneliness has cross-culturally affected older Chilean people living in rural areas and it appears that the COVID-19 pandemic has had a negative effect on well-being. This study proves that loneliness is related to several psychosocial variables that can be intervened.
Late Diagnosis of Swyer Syndrome in a Patient with Bilateral Germ Cell Tumor Treated with a Contraceptive Due to Primary Amenorrhea
Authors: Sowińska-Przepiera Elżbieta , Krzyścin Mariola , Przepiera Adam , Brodowska Agnieszka , Malanowska Ewelina , Kozłowski Mateusz , Cymbaluk-Płoska Aneta
Published: January 2023

Swyer syndrome is a special form of DSD (disorders of sex development), so-called pure gonadal dysgenesis with a karyotype 46, XY and a female phenotype. One of the most important problems in patients with DSD is the risk of gonadal tumors. We present a case of a 26-year-old patient with Swyer syndrome. The patient had primary amenorrhea and no puberty characteristics. In ultrasound imaging in the vicinity of the uterus, there were two homogeneous structures. A genetic diagnosis was also performed, which showed karyotype 46, XY. The patient underwent a bilateral gonadectomy. Histopathological examination revealed the presence of dysgerminoma in both dysgenetic gonads. The follow-up of five years now did not show any changes suspected of invasion. We concluded that the primary amenorrhea, along with the absence of development of sexual characteristics, should prompt an expanded diagnosis for disorders of sex development. Gonadal dysgerminoma should be suspected even in the absence of tumor features on ultrasound and blood laboratory tests. Early prophylactic gonadectomy could protect patients from developing tumors in dysgenetic gonads.
An Integrative Literature Review of Interventions to Protect People with Disabilities from Domestic and Family Violence
Authors: Saleme Pamela , Seydel Tori , Pang Bo , Deshpande Sameer , Parkinson Joy
Published: January 2023

Purpose: While domestic and family violence against people with disabilities is an ongoing and crucial public health concern, and awareness of the extent of violence against people with disabilities is growing, research on the field is still limited. Thus, the present review aims to systematically identify and synthesize evidence and effectiveness from intervention strategies to increase the awareness and skills of those with disabilities to reduce and prevent domestic and family violence against them. Method: PRISMA guidelines were followed to perform a systematic search of seven scientific databases to identify the peer-reviewed literature. Results: A total of 17 eligible studies were identified (14 evaluations and 3 descriptive studies), with most taking place in developed countries. Children and women are the most frequent victims, and they were therefore the most common target audience of the included studies. Sexual, physical, and verbal abuse were the most reported types of abuse, while financial abuse and neglect were studied less often. Interventions also focused on a diversity of disabilities, including learning, intellectual, mental, and physical impairments. Overall, the intervention strategies reflected a substantial homogeneity: focus on training and education as well as setting up channels and facilities for victims to seek help. Nine studies yielded significant positive outcomes using various strategies and techniques, while five studies had mixed results, and three studies only reported on the intervention strategies but did not evaluate the results. Conclusions: This review confirms a significant gap in the literature on domestic and family violence against people with disabilities and how to prevent and address the violence through evidence-based interventions. Several recommendations to improve future research and practice are proposed.
Links between COVID-19 and Alzheimer’s Disease—What Do We Already Know?
Authors: Rudnicka-Drożak Ewa , Drożak Paulina , Mizerski Grzegorz , Zaborowski Tomasz , Ślusarska Barbara , Nowicki Grzegorz , Drożak Martyna
Published: January 2023

Alzheimer’s disease (AD) is a life-changing condition whose etiology is explained by several hypotheses. Recently, a new virus contributed to the evidence of viral involvement in AD: the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the COVID-19 coronavirus disease. AD was found to be one of the most common COVID-19 comorbidities, and it was found to increase mortality from this disease as well. Moreover, AD patients were observed to present with the distinct clinical features of COVID-19, with delirium being prevalent in this group. The SARS-CoV-2 virus enters host cells through the angiotensin-converting enzyme 2 (ACE2) receptor. ACE2 is overexpressed in brains with AD, which thus increases the viral invasion. Furthermore, the inhibition of the ACE2 receptor by the SARS-CoV-2 virus may also decrease the brain-derived neurotrophic factor (BDNF), contributing to neurodegeneration. The ApoE ε4 allele, which increases the risk of AD, was found to facilitate the SARS-CoV-2 entry into cells. Furthermore, the neuroinflammation and oxidative stress existing in AD patients enhance the inflammatory response associated with COVID-19. Moreover, pandemic and associated social distancing measures negatively affected the mental health, cognitive function, and neuro-psychiatric symptoms of AD patients. This review comprehensively covers the links between COVID-19 and Alzheimer’s disease, including clinical presentation, molecular mechanisms, and the effects of social distancing.
Study on the Correlation between Life Expectancy and the Ecological Environment around the Cities along the Belt and Road
Authors: Li Chang , Wu Jing , Li Dehua , Jiang Yan , Wu Yijin
Published: January 2023

The impact of building the Belt and Road on the ecological environment and the health of the related cities along this belt deserves more attention. Currently, there are few relevant pieces of research in this area, and the problem of a time lag between the ecological environment and health (e.g., life expectancy, LE) has not been explored. This paper investigates the aforementioned problem based on five ecological indicators, i.e., normalized difference vegetation index, leaf area index, gross primary production (GPP), land surface temperature (LST), and wet, which were obtained from MODIS satellite remote-sensing products in 2010, 2015, and 2020. The research steps are as follows: firstly, a comprehensive ecological index (CEI) of the areas along the Belt and Road was calculated based on the principle of component analysis; secondly, the changes in the trends of the five ecological indicators and the CEI in the research area in the past 11 years were calculated by using the trend degree analysis method; then, the distributions of the cold and hot spots of each index in the research area were calculated via cold and hot spot analysis; finally, the time lag relationship between LE and the ecological environment was explored by using the proposed spatiotemporal lag spatial crosscorrelation analysis. The experimental results show that ① there is a positive correlation between LE and ecological environment quality in the study area; ② the ecological environment has a lagging impact on LE, and the impact of ecological indicators in 2010 on LE in 2020 is greater than that in 2015; ③ among the ecological indicators, GPP has the highest impact on LE, while LST and Wet have a negative correlation with LE.
Aphrophoridae as Potential Vectors of Xylella fastidiosa in Tunisia
Authors: Boukhris-Bouhachem Sonia , Souissi Rebha , Abou Kubaa Raied , El Moujabber Maroun , Gnezdilov Vladimir
Published: January 2023

The present study is an update on the situation of potential vectors of Xylella fastidiosa in Tunisia. Investigations in nine Tunisian regions (Nabeul, Bizerte, Béja, Jendouba, Zaghouan, Kairouan, Ben Arous, Tunis and Manouba) from 2018 to 2021 allowed for the observation of 3758 Aphrophoridae among a total of 9702 Auchenorrhyncha individuals collected by sweep net. Four Aphrophoridae species were identified with Philaenus tesselatus as most abundant (62%), followed by Neophilaenus campestris (28%), Neophilaenus lineatus (5%) and Philaenus maghresignus (5%). Aphrophoridae individuals were found to be particularly abundant in both forests of Nabeul and Jendouba, secondarily in olive groves and dry grassland. Furthermore, their distribution on weed hosts was followed in these two regions where nymphs and adults are widely distributed. P. tesselatus appears to be the most abundant species as determined either by conventional sweep netting for adults or by plant sampling on Sonchus, Smyrnium, Cirsium, Rumex, Polygonum and Picris for nymphs. Limited numbers of adults of P. maghresignus were detected by sweep netting, while nymphs of this species were found on Asphodelus microcarpus only. N. campestris was found in high numbers on plants belonging to the Poaceae family in forests, dry grassland and olive groves whereas N. lineatus occurred on herbs under or near olive trees and in dry grasslands.
Effects of Climatic Change on Potential Distribution of Spogostylum ocyale (Diptera: Bombyliidae) in the Middle East Using Maxent Modelling
Authors: Soliman Mustafa M. , Al-Khalaf Areej A. , El-Hawagry Magdi S. A.
Published: January 2023

Spogostylum ocyale (Wiedemann 1828) is a large robust species of bee fly (family Bombyliidae), known to be a larval ectoparasitoid as well as an important flower pollinator as an adult. This species has become extremely rare or has disappeared from many of its historic habitats due to substantial changes in floral and faunal compositions in recent years. Climate change and urbanisation, together with other anthropogenic activities, may be to blame for these changes. Distribution modelling based on environmental variables together with known occurrences is a powerful tool in analytical biology, with applications in ecology, evolution, conservation management, epidemiology and other fields. Based on climatological and topographic data, the current and future distributions of the parasitoid in the Middle East region was predicted using the maximum entropy model (Maxent). The model performance was satisfactory (AUC mean = 0.834; TSS mean = 0.606) and revealed a good potential distribution for S. ocyale featured by the selected factors. A set of seven predictors was chosen from 19 bioclimatic variables and one topographic variable. The results show that the distribution of S. ocyale is mainly affected by the maximum temperature of the warmest period (Bio5) and temperature annual range (Bio7). According to the habitat suitability map, coastal regions with warm summers and cold winters had high to medium suitability. However, future scenarios predict a progressive decline in the extent of suitable habitats with global climate warming. These findings lead to robust conservation management measures in current or future conservation planning.
Survival of Myocardial Infarction Patients with Diabetes Mellitus at the Invasive Era (Results from the Városmajor Myocardial Infarction Registry)
Authors: Skoda Réka , Nemes Attila , Bárczi György , Vágó Hajnalka , Ruzsa Zoltán , Édes István F. , Oláh Attila , Kosztin Annamária , Dinya Elek , Merkely Béla , Becker Dávid
Published: January 2023

Due to the lifelong nature of diabetes mellitus (DM), it has been demonstrated to have significant effects on patients’ morbidity and mortality. The present study aimed to assess the effects of DM on the clinical outcome and survival in patients who underwent percutaneous coronary intervention (PCI) due to myocardial infarction (MI) and to examine the relationship of DM to the type of the MI and to left ventricular (LV) and renal functions. A total of 12,270 patients with ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI) were revascularized at our Institution between 2005 and 2013. In this pool of patients, 4388 subjects had DM, while 7018 cases had no DM. In both STEMI and NSTEMI, the 30-day and 1-year survival were worse in diabetic patients as compared to non-diabetic cases. In the patients with DM, NSTEMI showed worse prognosis within 1-year than STEMI similarly to non-diabetic subjects. Regarding survival, the presence of DM seemed to be more important than the type of MI. Regardless of the presence of DM, reduced LV function was a maleficent prognostic sign and DM significantly reduced the prognosis both in case of reduced and normal LV function. Survival is primarily affected by LV function, rather than DM. Worse renal function is associated with worse 30-day and 1-year survival in both cases with and without DM. Considering different renal functions, the presence of DM worsens both short- and long-term survival. Survival is primarily affected by renal function, rather than DM. The results from a high-volume PCI center confirm significant the negative prognostic impact of DM on survival in MI patients. DM is a more important prognostic factor than the type of the MI. However, survival is primarily affected by LV and renal functions, rather than DM. These results could highlight our attention on the importance of recent DM treatment with new drugs including SGLT-2 inhibitors and GLP-1 antagonists with beneficial effects on survival.
Awake Prone Positioning for Non-Intubated COVID-19 Patients with Acute Respiratory Failure: A Meta-Analysis of Randomised Controlled Trials
Authors: Cheema Huzaifa Ahmad , Siddiqui Amna , Ochani Sidhant , Adnan Alishba , Sukaina Mahnoor , Haider Ramsha , Shahid Abia , Rehman Mohammad Ebad Ur , Awan Rehmat Ullah , Singh Harpreet , Duric Natalie , Fazzini Brigitta , Torres Antoni , Szakmany Tamas
Published: January 2023

Introduction: Awake prone positioning (APP) has been widely applied in non-intubated patients with COVID-19-related acute hypoxemic respiratory failure. However, the results from randomised controlled trials (RCTs) are inconsistent. We performed a meta-analysis to assess the efficacy and safety of APP and to identify the subpopulations that may benefit the most from it. Methods: We searched five electronic databases from inception to August 2022 (PROSPERO registration: CRD42022342426). We included only RCTs comparing APP with supine positioning or standard of care with no prone positioning. Our primary outcomes were the risk of intubation and all-cause mortality. Secondary outcomes included the need for escalating respiratory support, length of ICU and hospital stay, ventilation-free days, and adverse events. Results: We included 11 RCTs and showed that APP reduced the risk of requiring intubation in the overall population (RR 0.84, 95% CI: 0.74–0.95; moderate certainty). Following the subgroup analyses, a greater benefit was observed in two patient cohorts: those receiving a higher level of respiratory support (compared with those receiving conventional oxygen therapy) and those in intensive care unit (ICU) settings (compared to patients in non-ICU settings). APP did not decrease the risk of mortality (RR 0.93, 95% CI: 0.77–1.11; moderate certainty) and did not increase the risk of adverse events. Conclusions: In patients with COVID-19-related acute hypoxemic respiratory failure, APP likely reduced the risk of requiring intubation, but failed to demonstrate a reduction in overall mortality risk. The benefits of APP are most noticeable in those requiring a higher level of respiratory support in an ICU environment.
Quality of Life, Neurosensory Disorders and Co-Occurring Medical Conditions in Individuals on the Spectrum, with a Special Focus on Females Diagnosed with Autism: A Systematic Review
Authors: Davies Camron , Moosa Moeed , McKenna Keelin , Mittal Jeenu , Memis Idil , Mittal Rahul , Eshraghi Adrien A.
Published: January 2023

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that has a high prevalence and a significant economic impact. Our knowledge regarding neurosensory disorders and co-occurring medical conditions in the ASD population is limited, particularly for autistic women. Most of the studies include male participants or do not make comparisons with their female counterparts. The objective of this systematic review article is to explore the quality of life as well as the prevalence of neurosensory disorders and co-occurring medical conditions in individuals on the spectrum, with a special focus on autistic females. The literature search was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. A protocol of this systematic review was designed a priori and was registered in the PROSPERO database (registration number: CRD42022330368). We concluded that numerous medical areas were of concern. Autistic females are more likely than their male counterparts with ASD to suffer from psychiatric conditions such as post-traumatic stress syndrome, depression, and eating disorders. They are also more likely to report GI-related disturbances and chronic pain. Further investigations are warranted to determine quality of life, as well as the prevalence and severity of neurosensory disorders in individuals with ASD, specifically studies comparing autistic females with their male counterparts. The information derived from these studies will help develop better support systems for individuals with autism, particularly females on the spectrum, in pursuit of improving their quality of life.
Stenotrophomonas maltophilia: A Case Series and Review for an Uncommon Cause of Peritoneal Dialysis-Associated Infection
Authors: Floyd Lauren , Wu Henry H. L. , Chinnadurai Rajkumar , Ponnusamy Arvind
Published: January 2023

Peritonitis is a common and potentially serious complication of peritoneal dialysis (PD). Common organisms include Staphylococcus Aureus, enterococci, and coagulase-negative staphylococcus. However, Stenotrophomonas maltophilia (S. maltophilia) is an uncommon cause of PD-related infection. We describe a series of three cases of S. maltophilia PD infection (two cases of PD peritonitis and one case of PD exit-site infection) that were identified over a seven-week period in a single centre. The cases were treated with antibiotics (the primary antibiotic being co-trimoxazole) for a mean duration of 30 ± 7.9 days. All of the patients required PD catheter removal due to treatment failure with antibiotics. Hospital admission was required in two of the cases and one case resulted in mortality, with the cause of death directly associated with complications from S. maltophilia infection. A multi-disciplinary team using root-cause analysis did not identify a common link between our cases but highlighted possible risk factors contributing to these presentations. Given the relative rarity of S. maltophilia, evidence on its management options remains limited. In this article, we draw upon our own experiences and examine the literature available from previously published case reports and series. These reports highlight S. maltophilia as a complex and challenging organism to treat. Our experience demonstrated the importance of early PD catheter removal in S. maltophilia PD infection, as this is likely more effective than prolonged antibiotic therapy and hence a safer management option, considering the resistant nature of S. maltophilia.
Geochemical Features of Ground Ice from the Faddeevsky Peninsula Eastern Coast (Kotelny Island, East Siberian Arctic) as a Key to Understand Paleoenvironmental Conditions of Its Formation
Authors: Pismeniuk Anfisa , Semenov Petr , Veremeeva Alexandra , He Wei , Kozachek Anna , Malyshev Sergei , Shatrova Elizaveta , Lodochnikova Anastasiia , Streletskaya Irina
Published: January 2023

Understanding paleoenvironmental conditions of the permafrost formation allows us to estimate the permafrost carbon pool and its behavior upon thawing in a changing climate. In order to classify different types of ground ice and to reconstruct paleoenvironments, we examined geochemical data of ice wedges (IWs), tabular ground ice (TGI), and lens ice from the eastern coast of the Faddeevsky Peninsula (East Siberian Arctic). We analyzed isotope and ion composition, molecular composition of the gas phase, bulk biogeochemical parameters and dissolved organic matter (DOM) composition in ground ice samples. IWs formed in the Late Pleistocene under the coldest winter conditions and in the Holocene in proximity to the sea. The Holocene IWs have the highest mean d-excess (11–13‰) and a heavier isotope composition by an average of 6‰ compared with the Late Pleistocene IWs. We observe predominance of sea-salt fractions in ion composition of the Holocene IWs, while the Late Pleistocene IW shows enrichment in non-sea-salt component of SO42− (nssSO42−), which is probably associated with mineral leaching of deposits. Higher dissolved organic carbon (DOC) content in the Late Pleistocene IW (to 17.7 mg/L) may indicate more favorable vegetation conditions or lower degree of organic matter mineralization compared to Holocene IWs and TGI. CH4 concentrations were relatively low with a maximum value of 2.27 μmol/L. DOM composition, supposed to record the paleoenvironment of the freezing process, was for the first time tried as a biomarker for paleoenvironmental reconstructions of ground ice formation. Parallel factor (PARAFAC) analysis of EEM (Excitation-Emission matrix) of fluorescent DOM decomposes four components: P1–P3, which are related to allochthonous humic-like constituents, and P4, which is relevant to autochthonous fraction associated with microbial activity. The distribution of fluorescent DOM tracked the variability in both paleoclimate conditions of the IW formation (discriminating the Holocene and the Late Pleistocene IWs) and types of ground ice (IW and TGI), which demonstrates the potential of the used approach.
High Biofilm-Forming Ability and Clonal Dissemination among Colistin-Resistant Escherichia coli Isolates Recovered from Cows with Mastitis, Diarrheic Calves, and Chickens with Colibacillosis in Tunisia
Authors: Dhaouadi Sana , Romdhani Amel , Bouglita Wafa , Chedli Salsabil , Chaari Soufiene , Soufi Leila , Cherif Ameur , Mnif Wissem , Abbassi Mohamed Salah , Elandoulsi Ramzi Boubaker
Published: January 2023

Background: Escherichia coli (E. coli) is one of the main etiological agents responsible for bovine mastitis (BM), neonatal calf diarrhea (NCD), and avian colibacillosis (AC). This study aimed to assess resistance and virulence genes content, biofilm-forming ability, phylogenetic groups, and genetic relatedness in E. coli isolates recovered from clinical cases of BM, NCD, and AC. Materials/Methods: A total of 120 samples including samples of milk (n = 70) and feces (n = 50) from cows with BM and calves with NCD, respectively, were collected from different farms in Northern Tunisia. Bacterial isolation and identification were performed. Then, E. coli isolates were examined by disk diffusion and broth microdilution method for their antimicrobial susceptibility and biofilm-forming ability. PCR was used to detect antimicrobial resistance genes (ARGs), virulence genes (VGs), phylogenetic groups, and Enterobacterial repetitive intergenic consensus PCR (ERIC-PCR) for their clonal relationship. Results: Among the 120 samples, 67 E. coli isolates (25 from BM, 22 from AC, and 20 from NCD) were collected. Overall, 83.6% of isolates were multidrug resistant. Thirty-six (53.73%) isolates were phenotypically colistin-resistant (CREC), 28.3% (19/67) were ESBL producers (ESBL-EC), and forty-nine (73.1%) formed biofilm. The blaTEM gene was found in 73.7% (14/19) of isolates from the three diseases, whilst the blaCTXM-g-1 gene was detected in 47.3% (9/19) of isolates, all from AC. The most common VG was the fimA gene (26/36, 72.2%), followed by aer (12/36, 33.3%), cnf1 (6/36, 16.6%), papC (4/36, 11.1%), and stx1 and stx2 genes (2/36; 5.5% for each). Phylogenetic analysis showed that isolates belonged to three groups: A (20/36; 55.5%), B2 (7/36; 19.4%), and D (6/36; 16.6%). Molecular typing by ERIC-PCR showed high genetic diversity of CREC and ESBL E. coli isolates from the three animal diseases and gave evidence of their clonal dissemination within farms in Tunisia. Conclusion: The present study sheds new light on the biofilm-forming ability and clonality within CREC and ESBL-EC isolated from three different animal diseases in Tunisian farm animals.