bluuebunny/crossref_metadata_2025 huggingface dataset:
Overview of molecular subtype of medulloblastoma and role of MRI in their identification
Authors: Ashfaq Ahmad , Aisha Islam
Published: October 2022

Medulloblastoma is the most prevalent malignant brain tumor in children, accounting for roughly 15% to 20% of all malignancies of the Central Nervous System (CNS), for 40% of childhood, tumors are in the posterior fossa. Medulloblastoma is a heterogeneous combination of several subgroups with discrete characteristics, rather than a homogeneous illness. Genomic profiling of medulloblastomas revealed that the medulloblastoma may be further divided into four separate molecular subgroups. In this review, we aim to focus on the current state of understanding of the molecularity of the disease with a focus on genomic events that define the aforementioned subgroups and an overview of the molecular subtype of medulloblastoma upon discussing the following points (i) introduction to medulloblastoma and basic classification of the molecular subtype of medulloblastoma followed by their prevalence, age and gender discrimination, and specific molecular characterization. (ii) specific MRI features of the locality of a molecular subtype of medulloblastoma (iii) finally MRI distinguishable features for the identification of the specific molecular type. This review will enhance your knowledge regarding the subtype of medulloblastoma and the role of MRI in the identification of these subtypes.
[RETRACTED] abcde v1
Authors: Nitsche Nicolas
Published: October 2022

[RETRACTED]

new test protocol
Contemporary Theories of Stuttering Development
Authors: Novikova I. , Krivonkin K.
Published: October 2022

The article presents a theoretical analysis of contemporary models of persistent stuttering development in children and adults at the current period of development of science. The accumulated amount of scientific knowledge suggests that stuttering has a neurological basis: it is associated with disorders in the structure and function of the brain. On this basis, there have been emerged models of stuttering that link the cause of a speech disorder with an unstable speech motor system. Theories and models of stuttering based on cognitive and language processing are likely to be useful in that they have explanatory power in relation to the mechanisms that play an important role in the production of key symptoms of stuttering. Considering that stuttering is a complex disorder, the logical result of this was the proposal of multifactorial models of impaired speech fluency. The presented overview may be useful to psychiatrists, clinical psychologists, speech therapists, teachers, and practitioners interacting with children and adults with stuttering and other speech fluency disorders.
Errors of Verbal Episodic Memory in Schizophrenia Patients and in Non-Clinical Group with Different Profiles of Schizotypal Traits
Authors: Alfimova M. , Plakunova V. , Golimbet V.
Published: October 2022

The aim of the study was to provide a fine grain analysis of errors generated on word list learning tasks by schizophrenia patients and healthy controls with different profiles of schizotypal traits, since it can shed light on the cognitive mechanisms of memory impairment in these cohorts. 511 patients (mean age 33.40±11.53 years; 57% women) and 307 healthy controls (mean age 25.20±7.64 years; 73% women) completed the Rey Auditory Verbal Learning Test (A. Rey, 1964). The healthy subjects were assigned to groups with low, high, positive and negative schizotypy based on the Schizotypal Personality Questionnaire adapted by A.G. Efremov and S.N. Enikolopov (2002). In patients, symptomatology was assessed with the Positive and Negative Syndrome Scale adapted by S.N. Mosolov (2001). We analyzed the number of extra-list intrusions, their perseverations, frequency and strength of the associations with stimuli, as well as phonetic intrusions, intrusions from interference trails, and false recognition of semantic and phonetic lures. The results showed that patients are characterized by an increase in the number of extra-list intrusions and their perseverations, proactive interference and recognition of semantic lures; similar trends regarding extra-list intrusions and false recognitions were observed in the high schizotypy group. The data can be interpreted in favor of the idea of impairment of reality monitoring and insufficient encoding of stimulus’s surface features as inherent deficits of information processing in schizophrenia.
Problem-Oriented Personality Type in Patients with Tinnitus: Specificity and Practical Relevance in Diagnostics
Authors: Melehin A.
Published: October 2022

The article presents the results of an empirical study of personality characteristics of the presence or absence of a problem-oriented personality type in 55 patients with (average age 49.6±11.2 years, 60% of men and 40% of women) and without (average age 48.5±12.2 years; 55% of men and 45% of women) subjective idiopathic tinnitus. The use of the Tinnitus Severity Index (TSI), the type-D Scale (DS-14), the Eysenck Personality Questionnaire (EPQ) and the Emotional stability assessment subscale from the Five-Factor Personality Inventory (FFPI) made it possible for the first time to describe the affective style of patients with tinnitus. Compared to people without tinnitus, patients with tinnitus have statistically and clinically significant higher levels of neuroticism, negative affectivity and social inhibition (isolation), on the one hand, and lower levels of extraversion and emotional stability, on the other hand. Patients with tinnitus and severe tinnitus distress are more likely to have a problem-oriented personality type, a problem-oriented personality type is associated with the presence of tinnitus and contributes to its perceived severity. Negative affectivity, as one of the dimensions of a problem-oriented personality type, has an adverse effect on the severity of tinnitus, and is a risk factor for tinnitus distress. In this regard, the article provides practical recommendations for the psychological examination of patients with tinnitus and the tactics of cognitive behavioral therapy.
Adolescent Resilience Profiles (on the Example of Adolescents with Congenital, Acquired Disabilities and Healthy Peers)
Authors: Odintsova M. , Lubovsky D. , Gusarova E. , Ivanova P.
Published: October 2022

The problem of the research is important in the context of psychological assistance and interaction with adolescents with disabilities. The study aimed to carry out a comparative analysis of the resilience profiles of adolescents with congenital (cerebral palsy), acquired disabilities (oncology, rheumatic diseases) and healthy peers. The study involved 51 adolescents with cerebral palsy, 61 with oncological diseases, 51 with rheumatic diseases and 86 conditionally healthy adolescents aged 13 to 18 years old. In total it embraced 249 teenagers (mean age 14.94+1.48), of which 128 were male and 121 were female. There were used the following methods: the “Victimity” questionnaire (M.A. Odintsova, N.P. Radchikova), “Resilience Test” (E.N. Osin, E.I. Rasskazova) and “COPE” questionnaire (E.I. Rasskazova, T.O. Gordeeva, E.N. Osin). The study revealed significant differences in the resilience profiles of adolescents from different groups: healthy teenagers are mainly characterized by unstable and resilient profiles; adolescents with oncology and rheumatic diseases — by all three profiles; adolescents with cerebral palsy — by victim and unstable ones. The female part of the sample, unlike the male part, are characterized by unstable and victim profiles. The most significant differences in groups with different resilience profiles were found in coping strategies related to the dysfunctional coping style. The use of coping strategies: behavioral disengagement, mental disengagement, concentration on emotions and humor leads to a decrease in resilience in the boys of the entire sample. Concentration on emotions, behavioral disengagement, mental disengagement, and infrequent use of active coping are predictors of reduced resilience in girls.
Ideas about the Consequences of Bad Character and Improper Behavior in Adolescents with Intellectual Disabilities
Authors: Steblyak E.
Published: October 2022

The materials of an empirical study of ideas about the consequences of the manifestation of bad character and improper behavior of a person in relationships with people, obtained from a sample of 77 respondents with intellectual disability: 52 of them are mentally retarded respondents aged 13-16 years, studying in grades 6-8 of adaptive school (34 of them male, 18 – female) and 25 respondents with a delay of mental development of 13-16 years old, studying in grades 8-9 of secondary school (of which 18 are male and 7 are female). A modified technique by M.A. Kholodnaya "Formulation of problems" was used. Respondents were asked to list a number of problems that arise in a person's life due to his bad character and improper behavior in relationships with people. The technique of inductive categorization was used in the analysis of interview data. The work is aimed at clarifying the ideas of the nuclear and peripheral parts of the structure of the collective representation of adolescents with mental retardation and mental retardation about the consequences of manifestations of bad character and improper behavior. The direction of the forecast is revealed to identify the consequences for the subjective experiences of a person with a bad character, the system of his interpersonal and activity relations. The productive aspects of collective representation, which serve as a guideline for the construction of pedagogical discourse of correctional and developmental orientation, are clarified.
Self-Realization of Persons with Atypical Development: A Comparative Analysis
Authors: Shipova N.
Published: October 2022

This study aims to define the specifics of self-realization of persons with atypical development of various nosologies. The materials of an empirical study obtained on a sample of individuals with typical (n=232; M=26.34±13.47 y.o.) and atypical development (n=177; M=28.89±18.16 y.o.) are presented. The sample includes the following nosological groups: visual impairment (n=15), hearing impairment (n=9), musculoskeletal disorders (n=27), intellectual impairment (n=81), the presence of disabling diseases (n=45). The methodological tools included the Personality Self-Realization Judgment Test (S.I. Kudinov, 2012); semi-structured interview to study the characteristics, barriers, resources of self-realization. The specificity of self-realization of persons with atypical development was revealed by comparing these persons with atypical development and a group of normatively developing respondents. Persons with hearing impairment are more external, but less active in self-realization. Persons with impaired vision are more passive in self-realization, more often they consider it ineffective. Persons with musculoskeletal disorders are more pessimistic about self-realization, more socially oriented, recognize the dependence of self-realization on circumstances, but they consider it unique. Persons with disabling diseases strive less for self-realization in a personal sense, feel less potential for self-realization and optimism in relation to it; we noted less pronounced social-corporate attitudes and creativity of self-realization. Persons with intellectual disabilities are less likely to seek personal and professional/educational self-realization, demonstrate less activity and internality of efforts, evaluate it as less effective and unique, but they evaluate the methods used as non-standard. Differences in the success of self-realization in the professional and educational spheres are revealed. The circumstances of the external environment are the dominant barrier in individuals with atypical development. The main resource of self-realization is social support. Significant differences in subjective assessments of the success of self-realization in various spheres of life in different nosological groups were noted in the field of professional/educational self-realization.
To the Anniversary of Juri Mikadze
Authors: Goryacheva T.
Published: October 2022

The famous Russian psychologist and neuropsychologist Yuri Mikadze turned 75 on May 26. The staff of the Faculty of Clinical and Special Psychology of the Moscow State Pedagogical University, the editorial board of the journal "Clinical and Special Psychology" sincerely congratulate Yuri Mikadze on his anniversary, wishes health, happiness and long years of fruitful work in science and education. These congratulations are joined by the staff of the Department of Clinical Psychology of the Faculty of Clinical Psychology and Social Work of the Pirogov Russian National Research Medical University.
Human-Induced Earthquakes: The Performance of Questionnaire Schemes
Authors: Foulger Gillian R. , Wilkinson Maxwell W. , Wilson Miles P. , Gluyas Jon G.
Published: October 2022

Questionnaire schemes are commonly used to investigate whether or not certain earthquakes were induced by industrial activity. Such schemes are subjective and cannot be assumed to give the “right” answer in a scientifically rigorous sense. They only yield current expert opinion on how strongly existing data support an induced or natural cause. Work to optimize a standard generic questionnaire is ongoing. To this end, we designed and compared three schemes that produce measures of data quality and support for human induction. One scheme is a generalization of an existing questionnaire for assessing fluid-injection-associated earthquakes. A second scheme is purely subjective, and a third scheme is purely objective. Because questionnaires are opinion-dependent, different analysts produce different results. We tested the three schemes on 55 diverse cases from the Human-Induced Earthquake Database with the maximum magnitude earthquakes M 4.1–7.9. The results of three analysts correlate with each other at the r ∼ 0.4–0.9 level. Higher correlations were found between schemes than between analysts. A simple, rapid, five-question Likert scale correlated well (r = 0.79) with results from a sophisticated, time-consuming scheme. Measures of data quality were uncorrelated with Mmax, and support for human induction correlated weakly negatively with Mmax. One scheme identified an earthquake sequence not proposed to have been human-induced but that has induced characteristics. New mechanisms of induction are still being recognized, and it is important that questionnaire schemes do not preclude new developments in future.
Anatomical variations of radial artery and its morphology with clinical implications
Authors: Mukherjee Barnali , Sarkar Amita , Samanta Shubhrangsu , Kannabathula Ajay Babu
Published: October 2022

Background: The radial artery (RA) is a continuation of the brachial artery and is one of the major blood supplying vessels to the structures of the forearm. It is originated in the cubital fossa at the level of the neck of the radius. It runs on the lateral aspect of the forearm before it reaches the wrist and branches out to supply the hand. The RA is also important clinically due to its location at the wrist, as it can be felt as a pulse and can be used to determine the heart rate. It is the artery of choice for coronary artery angiography, percutaneous coronary artery intervention, cannulation, and others. The main objective of this study is to study the variation in origin and course of the RA in cadavers.Methods: The present study was conducted with 100 upper limbs of 50 cadavers in the department of anatomy, Gouri devi institute medical sciences and hospital, Durgapur, West Bengal over a period of 2 years. By conventional dissection method, the axillary region, arm, forearm, and hand of each limb were dissected to clarify the course and branches of the RA. This anatomical descriptive study was conducted after approval of the ethical committee. The study period was March 2018 to August 2020.Results: RA took high origin from the brachial artery in arm is 6.66%. The maximum length was measured was 23.7 cm, minimum length was 18 cm and the mean value is 21.25. The RA after giving its branches continued in the forearm. In 96.88%, RA arose normally in cubital fossa.Conclusions: The anatomy and morphology of RA have many documented variations. Radiologist and surgeons should have a good understanding of normal morphological variations of RA.
Refractory hypokalemia: a case report
Authors: Setiawan Indra , Wirawan I. Made S.
Published: October 2022

Hypokalemia is a common electrolyte disturbance in hospitalized patients, which prompts appropriate identification of hypokalemia symptoms and signs. As many as 20% of hospitalized patients are found to have hypokalemia. Many hypokalemia patients could also have systemic disease. A 55-year-old woman was presented with weakness, nausea, and vomiting for 2 days before admission. Vomit consisted of water; there was no blood in the vomit. Defecation was normal; consistency and odor of feces were normal. Patient had diabetes and was already on insulin regiment. Insulin was discontinued during hospitalization since blood sugar was close to lower limit. Electrocardiography (ECG) was within normal limit. Symptoms and signs of hypokalemia may not be readily apparent, as seen in this case. Treatment of hypokalemia should intend not to only replenish potassium, but also to identify underlying cause. Causes include gastrointestinal losses, intracellular shift, renal potassium losses, and inadequate intake.
Superior vena cava syndrome management in limited source setting: a case report
Authors: Setiawan Indra , Sunaka I. Wayan , Yaniswari Ni Made D.
Published: October 2022

Superior vena cava syndrome (SVCS) is syndrome caused by mass compression, tumor invasion, and/or thrombosis of SVC. In the past, SVCS was mostly linked to infection. Nowadays, SVCS is mostly linked to malignant tumor and medical procedures. Most common malignant cause of SVCS is non small cell lung cancer. A 69-year-old man was presented with breathing difficulty. Symptom began 4 months before admission, with worsening of symptom since 2 weeks before admission. Symptom improved with sitting position, and worsened with supine position. Patient had been sleeping with 2 pillows. Patient had productive cough and hoarseness. Swelling of face and neck were present. Collateral vein distention was visible in the area of head, neck, and chest. Physical examination of lung revealed decreased vesicular breath sound at right side. Non pitting edema was found at both sides of upper extremity. SVCS in this case can be categorized into grade 2, chronic SVCS case. CT showed center right lung mass, although malignant cells were not obtained from pleural puncture and CT guided needle biopsy. Staging of mass was T4N3M1a. Mass finding at the center of right lung is in accordance with the previous findings that SVCS generally arise from lung (not mediastinum), and that right sided masses are generally more likely to cause SVCS. Management in this case was done by giving corticosteroid and diuretic. Surgery, radiotherapy, and immunotherapy were not done since malignancy diagnosis hadn’t been able to be concluded.
Mesenchymal stem cells to treat female infertility; future perspective and challenges: A review
Authors: Saeed Yasmeen , Liu Xiaocui
Published: October 2022

Infertility negatively impacts the overall health and social life of affected individuals and couples. Female infertility is their inability to perceive pregnancy. To date, polycystic ovary syndrome, primary ovarian insufficiency, fallopian tube obstruction, endometriosis, and intrauterine synechiae have been identifiedas the primary causes of infertility in women. However, despite the mutual efforts of clinicians and research scientists, the development of an effective treatment modality has met little success in combating female infertility. Intriguingly, significant research has demonstrated mesenchymal stem cells as an optimal source for treating infertility disorders. Therefore, here we attempted to capsulize to date available studies to summarize the therapeutic potential of mesenchymal stem cells in combating infertility in women by focusing on the underlying mechanism through which stem cells can reduce the effects of ovarian disorders. Furthermore, we also discussed the preclinical and clinical application of stem cell therapy, their limitation, and the future perspective to minimize these limitations.
Key words: Pregnancy, Infertility, Female, Stem cell transplantation, Uterine diseases, Mesenchymal stem cells.
Sexual and reproductive health aspects in women with polycystic ovary syndrome: An integrative review
Authors: Kalhor Mehri , Mohammadi Eesa , Shahali Shadab , Amini Leila , Moghaddam-Banaem Lida
Published: October 2022

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women worldwide, affecting their sexual and reproductive health (SRH). Objective: This integrative review aimed to identify SRH aspects in women with PCOS by consolidating the findings from previous studies.
Materials and Methods: The present integrative review was conducted through an electronic systematic review search of 1052 manuscripts published from April 2000 to March 2020 using PubMed, SCOPUS, Web of Science, Embase, Google Scholar, MEDLINE, Science Direct, Ovid, and the Cochrane Library. After at least 2 researchers evaluated the articles based on the inclusion and exclusion criteria, 27 papers were accepted. The data were analyzed by thematic analysis.
Results: 9 main themes of SRH were obtained: 1) the impact of PCOS-related complications on reproductive health; 2) the lifelong effect of PCOS on reproductive patterns; 3) PCOS and adverse reproductive and pregnancy outcomes; 4) women’s need for understanding complications; 5) the financial burden of the disease; 6) women’s life experiences and quality of life; 7) sexual disorders; 8) psychological concerns and issues; and 9) femininity feelings and roles.
Conclusion: We were able to identify and categorize various aspects of SRH needs for women with PCOS. These categories can facilitate a more comprehensive assessment of SRH, including previously neglected areas. We suggest that these aspects should be considered in the health plans of women with PCOS.
Key words: Polycystic ovary syndrome, Reproductive health, Sexual health, Women
Comparison of uterine preservation versus hysterectomy in women with placenta accreta: A cross-sectional study
Authors: Mohammad Jafari Razieh , Najafian Mahin , Barati Mojgan , Saadati Najmieh , Jalili Zorvan , Poolad Atefeh
Published: October 2022

Background: Placenta accreta spectrum (PAS) is a major cause of obstetric bleeding in third trimester of pregnancy.
Objective: This study aimed to compare the outcomes of uterine preservation surgery vs. hysterectomy in women with PAS.
Materials and Methods: In this retrospective cross-sectional study, the records of 68 women with PAS referred to the Imam Khomeini hospital in Ahvaz, Iran, between March 2015 and February 2020 were included. The women were divided into 2 groups according to surgical approach: hysterectomy vs. uterine preservation (including just removing the lower segment, removing the lower segment with uterine artery ligation, or removing the lower segment with hypogastric artery ligation during cesarean section). The need for blood components transfusion (whole blood, packed cells, and fresh frozen plasma), maternal mortality, duration of surgery, and length of hospitalization were compared between groups.
Results: In total, we investigated 68 women between the ages of 24-45 yr (mean age of 32.88 ± 5.08 yr). All participants were multiparous and underwent cesarean section. Furthermore, 28 women (41.2%) had a history of curettage. In total, 24 women (35.3%) underwent a hysterectomy, and 44 (64.7%) underwent uterine preservative surgeries. There were no significant differences between groups of hysterectomy and uterinepreservative surgeries in terms of the need for blood components transfusion, maternal mortality, duration of surgery, and length of hospitalization.
Conclusion: The results of this study showed no significant difference between groups regarding the studied outcomes. Therefore, conservative surgeries could be used to preserve the uterus instead of hysterectomy in women with PAS.
Key words: Placenta accreta, Placenta diseases, Pregnancy complications,Conservative treatment, Hysterectomy.
Addition of intramuscular to vaginal progesterone for luteal phase support in fresh embryo transfer cycles: A cross-sectional study
Authors: Jalaliani Samaneh , Davar Robab , Akbarzadeh Farzad , Emami Fatemeh , Eftekhar Maryam
Published: October 2022

Background: Luteal phase deficiency is common in assisted reproductive technology and is characterized by inadequate progesterone production. Various studies have shown that administration of progesterone in fresh embryo transfer cycles increases the rate of clinical pregnancy and live birth rate. Progesterone administration has variable types: oral, vaginal, oil-based intramuscular, and subcutaneous.
Objective: This study aims to compare the effect of adding intramuscular progesterone to the vaginal progesterone for luteal phase support in the fresh embryo transfer cycle.
Materials and Methods: This study reviewed the information related to 355 women who had a fresh embryo transfer between March 2020 and February 2021 at the Yazd Reproductive Sciences Institute, Yazd, Iran. The participants population were divided into 2 groups based on the type of luteal phase support regime: group I (n = 173) received 400 mg vaginal progesterone alone twice a day from the day of ovum pick up; and group II (n = 182) received 50 mg IM of progesterone in addition to vaginal progesterone 400 mg twice a day from the day of ovum pick up. Chemical and clinical pregnancy rates were compared between groups.
Results: The basic characteristics of groups were statistically similar. The rates of chemical and clinical pregnancy were higher in the vaginal plus IM progesterone group than in the vaginal progesterone group. Moreover, chemical pregnancy showed a significant difference between the groups (p = 0.011).
Conclusion: Our findings demonstrated that the addition of IM progesterone to the vaginal progesterone improves the chemical pregnancy rate in fresh embryo transfer.
Key words: Luteal phase, Progesterone, Assisted reproductive technology, Embryo transfer.
Comparison of sexual function in infertile women with polycystic ovary syndrome and endometriosis: A cross-sectional study
Authors: Daneshfar Zahra , Jahanian Sadatmahalleh Shahideh , Jahangiri Nadia
Published: October 2022

Background: Infertility is one of the issues affecting sexual function (SF). Infertility is also one of the complications of polycystic ovary syndrome (PCOS) and endometriosis.
Objective: This research seeks to assess and compare SF and the prevalence of sexual dysfunction in infertile women with PCOS and endometriosis.
Materials and Methods: A cross-sectional study was carried out with a sample of 630 (210 infertile women with endometriosis, 210 infertile women with PCOS, and 210 healthy women of childbearing age as the control group). SF was assessed by the female sexual function index (FSFI). Descriptive statistics and inferential statistics were used to analyze the data. The primary outcome measured was FSFI score. Secondary outcome was hospital anxiety and depression scale score.
Results: The results showed that the mean score of the total FSFI in the 2 groups of PCOS and endometriosis was lower than the control group (p < 0.001). In addition, women with higher education (university education) had a higher total FSFI.
Conclusion: Sexual dysfunction rates are high in infertile women with endometriosis and PCOS. Infertility service providers in infertility centers need to pay attention to this issue.
Key words: Polycystic ovarian syndrome, Endometriosis, Infertility, Sexual dysfunction.
Representation of a ‘positive experience’ of surrogacy in Yazd, Iran: A qualitative study
Authors: Ghane-Mokhallesouni Zahra , Askari-Nodoushan Abbas , Razeghi Nasrabad Hajieh Bibi , Kalateh Sadati Ahmad , Dehghani Firouzabadi Razieh
Published: October 2022

Background: The social and cultural challenges facing surrogate mothers have been explored in several studies. However, few studies have discussed the motivations of surrogate mothers, their expressions and interpretations of their lived experiences, and their feelings of personal and spiritual satisfaction.
Objective: This study aims to present the positive experiences of surrogate mothers from a phenomenological perspective.
Materials and Methods: Using a phenomenological approach, this study was conducted from September 2020 to January 2021 in the city of Yazd, Iran. Participant observation and semi-structured interviews were used to collect the data among 12 participants with at least 1 experience of surrogate motherhood.
Results: Our findings showed that, despite having had harsh physical and socio-cultural experiences such as fear of social labeling and stigma, participants felt a kind of inner satisfaction and a positive view of their actions. A core theme found in the study was mothers’ satisfaction. The main categories included feminine self-sacrifice and positive rewards. Feminine self-sacrifice included 2 sub-categories: creating happiness and conveying motherly feelings, while positive rewards included good childbirth, family acceptance, and halal income.
Conclusion: This study showed that surrogate mothers experience conflicting feelings of inner satisfaction and social stigma during surrogacy. Some of those interviewed were willing to go through surrogacy again, but they feared social labeling and stigma, being misunderstood by others who are not fully informed about surrogacy, and being subjected to family and social disapproval.
Key words: Surrogate mothers, Emotions, Personal satisfaction, Infertility.
Birth of spinal muscular atrophy unaffected baby from genetically at-risk parents following a pre-implantation genetic screening: A case report
Authors: Adrainus Polim Arie , Handayani Nining , Kesumapramudya Nurputra Dian , Melanie Lubis Anggia , Sirait Batara , Jakobus Dennis , Boediono Arief , Sini Ivan
Published: October 2022

Background: Spinal muscular atrophy (SMA) is characterized by the homozygous deletion of the survival motor neuron-1 gene. Pre-implantation genetic testing for monogenic diseases through in-vitro fertilization program was developed to provide a reliable genetic diagnostic method for SMA.
Case presentation: The couple who was confirmed as carriers of SMA visited the Morula IVF Clinic, Jakarta, Indenesia seeking for an in-vitro fertilization expert opinion in relation to the pre-implantation genetic testing for SMA. Utilizing polymerase chain reaction-restriction fragment length polymorphism, we have successfully screened for unaffected embryos that were characterized by a normal presence of the survival motor neuron-1 exon 7-8 and survival motor neuron-2 exon 7-8. The frozen embryo was subsequently transferred and a healthy unaffected female baby was born with undetected deletion of the survival motor neuron-1 gene.
Conclusion: This successful embryo pre-implantation screening case could potentially accommodate the demands of genetically at-risk couples who are apprehensive about conceiving a child who might inherit monogenic disorders such as SMA.
Key words: In-vitro fertilization, Spinal muscular atrophy, Preimplantation diagnosis.
Effective Dimensions of Medical Equipment Maintenance Management in Educational Hospitals: A Qualitative Study
Authors: Ahadinezhad Bahman , Khosravizadeh Omid , Maleki Aisa , Ghanbari Elnaz , Shafiei pour Mahla , Safdari Mahdi
Published: October 2022

Background: Medical equipment maintenance plays an important role in improving the equipment's function, increasing its effectiveness and efficiency, providing continuous health services, and improving the quality of services. This study is conducted to investigate the factors affecting medical equipment maintenance management.
Methods: The present study was a qualitative investigation based on content analysis that was conducted in 2021. Data collection method was an open ended interview. The interviewees included all medical equipment operators and technicians of educational and medical centers affiliated with Qazvin University of Medical Sciences. The semi-structured interview guide was used as a data collection tool. Qualitative data obtained from interviews were analyzed by the content analysis method. The obtained coded were classified into dimensions and components using MAXQDA Software12 .
Results: According to the findings, categories of time constraints, access to information, instructions and programs, type and number of equipment, financial constraints, user, patients, training programs, and equipment repair agencies were the most important factors affecting medical equipment maintenance management.
Conclusion: Observing purchasing standards and guaranteed equipment, training all the staff involved, developing and explaining instructions and programs are essential for optimal equipment maintenance. These measurements will reduce the cost of repairing.
g medical equipment and the need to purchase equipment; improve equipment, service quality performance, patient and user safety; and increase the device life.
The Challenges of Iran's Pharmaceutical Export: A Qualitative Content Analysis
Authors: Ansari Mina , Takian Amirhossein , Yazdi-Feyzabadi Vahid
Published: October 2022

Background: Development of non-oil exports, including pharmaceutical products is one of the most important economic development strategies. This study aims to explain challenges of pharmaceutical export in Iran by using the sources and content of online media news.
Methods: This was a qualitative study which analyzed the content of general and specialized online media news in Iran (conventional approach) from January 20, 2017 to January 20, 2020. Data sources were selected using the purposive sampling method .Then, the eligible news was determined by quota sampling method and was inductively analyzed in MAXQDA10.
Results: The identified challenges were divided into five main categories including the domestic market of medicines, pharmaceutical manufacturing, financing, marketing and diplomacy. The most important challenges were related to financing and marketing.
Conclusion: Iran's position regarding worldwide export of drugs is not satisfactory. The target markets for drug exports should be developed using a national economic program and appropriate diplomacy, in addition to improving the quality of drug production.
The Relationship between Quality of Work Life and Job Satisfaction among Nurses in a Teaching Hospital in 2020
Authors: Dargahpour Maryam , Jalali Parisa , Mohammadi Mohsen
Published: October 2022

Background: Job satisfaction and the quality of work life are measured as indicators of organizational development in many studies.Work’s nurses affected from this two variables .This research aims to study the relationship between quality of work life and job satisfaction among nurses.
Methods: This was a descriptive analytic study. Research population included 538 nurses in Golestan hospital in Ahvaz in 2020.  111 nurses were selected through simple random sampling. Data collection instruments were Walton quality of work life and Whiskey and Chrome job satisfaction questionnaires. The reliability and validity were measured. Data were analyzed through descriptive statistics, Pearson correlation analysis, independent t-test and ANOVA in SPSS20.
Results: In this study, 32.40 % of the participants were male and 67.60 % were female. Quality of work life and job satisfaction showed a significant and moderate correlation (r = 0.36, P-value < 0.001).  Results indicated a significant correlation between job satisfaction and components of quality of work life (P-value< 0.05), except for the general atmosphere of working life (P-value> 0.05). There was no significant correlation between the study's variables and demographic characteristics.
Conclusion: There is a significant relation between the quality of work life and job satisfaction. Job satisfaction among nurses in Ahvaz hospitals can be increased by implementing programs to improve the quality of work life.
The Effect of Intellectual Capital on Innovative Performance with the Mediating Role of Qazvin Health Staff’s Empowerment: A Path Analysis
Authors: Khosravizadeh Omid , Ahadinezhad Bahman , Sheikh Bibi Sara
Published: October 2022

Background: Nowadays, since many health care organizations are facing a crisis of declining productivity and labor force stagnation, productivity can be improved through identifying and strengthening the components affecting the labor force productivity and performance. Thus, the present study was aimed at determining the effect of intellectual capital on innovative performance with the mediating role of health staff’s empowerment in Qazvin University of Medical Sciences.
Methods: This is a descriptive-analytical cross-sectional study carried out in 2021. Three hundred and four staff of the Health Department and Health Networks participated in the research by the available sampling method. The Bontis questionnaire was employed for measuring the intellectual capital, the Spritzer questionnaire for measuring staff’s empowerment, and the Huang and Li questionnaire for measuring innovative performance. Moreover, for preliminary data analysis, SPSS25 Software was used as well as AMOS software for structural equation modeling at a significance level of 0.050 %.
Results: The results of the path coefficient among the model variables on each path, corresponding to the research hypotheses, are positive, revealing a positive relationship among the research variables. The path coefficient of the direct relationship between intellectual capital and innovative performance was equal to 0.767 (P-value < 0.001). Moreover, the relationship between intellectual capital and empowerment was equal to 0.306, and between empowerment and innovative performance was equal to 0.153, both of which were significant (p < 0.001). Furthermore, indices of fit including NFI = 0.652, RMSEA = 0.064, GFI = 0.710, and CFI = 0.769 exhibited a relatively good fit of the final model.
Conclusion: Given the direct relationship between model variables, the University of Medical Sciences’ managers and health officials should provide the bed for improving the capacity of human resources and innovative performance through developing intellectual capital besides creating a platform to play an effective role in the organization. Accordingly, effective and innovative performance based on responding to the human resources’ changing needs in all sectors may be imagined.
Meta-Analysis of Studies on the Effects of Rehabilitation on the Quality of Life in Patients with Heart Diseases in Iran from 2007 to 2017
Authors: Niazi Mohsen , Zolfaghari Akbar , Vahedian Morteza , Mahdian Aida
Published: October 2022

Background: Heart disease is one of the most common types of diseases in the contemporary world. In the treatment process, rehabilitation programs can bring patients back to the course of daily life as soon as possible, and improve their functional levels life quality. The present study used the meta-analysis method on studies that have examined the effects of rehabilitation on the life quality of heart patients.
Methods: Based on meta-analysis method, the researchers tried to compile different studies conducted at different periods in the form of a specific subject. Then, the research results were examined in a systematic way. The statistical population of this study included all the scientific and research papers on the effects of rehabilitation programs regarding the life quality of heart patients. They were studies from 2007 to the end of 2017 published in scientific journals. 44 studies regarding the life quality of heart patients have been conducted. Finally, 10 studies were selected as a sample and meta-analysis was performed using the Comprehensive Meta-Analysis Software 2(CMA2).
Results: Results of the study demonstrate that all the studies on the effects of rehabilitation on life quality of heart patients were significant. This means that the relationship between the variables considered in each study was statistically related, and this relationship was correct.
Conclusion: It is concluded that sports rehabilitation has the highest impact on life quality and physical and mental dimensions. Generally, all effects’ sizes are significant. This confirms that the results of all the research conducted regarding the effect of rehabilitation programs on the life quality of heart patients are correct; rehabilitation has an effect on improving the quality of life.
Carne artificial: técnicas de cultivo e perspectivas da cadeia produtiva
Authors: Justino Heloisa de Fátima Mendes , Cunha Jeferson Silva , Pacheco Flaviana Coelho , Pacheco Ana Flávia Coelho , Leite Júnior Bruno Ricardo de Castro
Published: October 2022

A demanda por produtos de origem animal cresce ao longo dos anos, o que gera preocupações ambientais, sociais e econômicas. A sustentabilidade na cadeia produtiva de alimentos é um assunto que vem sendo muito discutido, visto que, se a população não mudar seus hábitos e a ciência não buscar formas de preencher essa lacuna, um dos maiores problemas que o ser humano enfrentará no futuro será a fome. Os atuais sistemas de produção de carne são uma fonte de poluição e um consumo significativo de terra e recursos hídricos. A carne artificial é uma alternativa frente aos problemas encontrados devido a sua forma mais sustentável de cultivo. Desta forma, essa revisão aborda as técnicas de cultivo e as perspectivas dessa cadeia produtiva.
Retrospective analysis algorithm for identifying and localizing residual reserves of the developed multilayer oil field
Authors: Burkhanov Ramis N. , Lutfullin Azat A. , Maksyutin Alexander V. , Raupov Inzir R. , Valiullin Ilsur V. , Farrakhov Ilnur M. , Shvydenko Maksim V.
Published: October 2022

Long-term phased development of a multi-layer field, including tens and hundreds of oil-bearing horizons and local deposits, combined with their vertical and horizontal separation, creates conditions for the formation of residual oil reserves. For the purpose of identifying and spatial localization of residual reserves, an algorithm for retrospective analysis was developed and applied on the example of the Upper and Lower Devonian terrigenous deposits of the Romashkinskoe oil field, which have been developed since 1952. The long history of geological study and development of oil-bearing formations of the Pashiysky D1 (layers g and e), Mullinsky D2, Ardatovsky D3, Vorobyevsky D4 and Biysky D5 horizons is analyzed according to the data of 2605 wells. It is proposed to single out 6 categories of formations and the reserves contained in them. Previously undeveloped formations composed of conditioned reservoirs are classified as category 1. Formations composed of more clayey and less permeable reservoirs are awarded with category 2. Category 3 includes previously developed formations, but left before reaching the limit of water cut, and category 4 – currently being developed intervals. The least promising are those that are stopped after reaching the maximum water cut (category 5), as well as wedged out, replaced by non-reservoirs or considered water-bearing (category 6) formations. Categories were mapped to identify, visualize and describe the main patterns in the distribution of residual reserves, which are established both in single wells and in bypassed oil that include a group of wells. The algorithm was tested on the corporate information base of historical data on geological exploration, research and development of the Abdrakhmanovskaya area of ​​the Romashkinskoe oil field. Examples of experimental workover operations to include the identified residual reserves in the development are given.
Factor analysis of gas wells’ operating parameters
Authors: Shchekin Alexander I. , Verzhbitsky Vyacheslav V. , Gunkina Tatiana A. , Handzel Alexander V.
Published: October 2022

The paper discusses methodological approaches to the use of deterministic factor analysis for identifying the sources of changes in gas wells’ parameters under steady-state gas inflow obeying linear and non-linear filtration laws. Factor analysis methods make it possible to quantify the degree of influence of individual factors on the deviation of the indicator under study. In accordance with the methodology of factor analysis, mathematical models of the factor system were substantiated for linear and non-linear gas filtration, a set of factors of influence was determined, and ready-made solutions for factor analysis of gas wells’ operating parameters were obtained. In the paper, the method of weighted finite differences was substantiated and investigated with the aim of factor analyzing gas wells’ mode of operation and obtaining formulas to calculate the increment in gas production caused by changes in factors. Approbation of working formulas for assessing the degree of influence of factors on either positive or negative deviations in the gas flow rate was carried out with respect to the parameters of the wells of underground gas storages in the cycles of withdrawal and injection. The obtained formulas for factor analysis of gas wells make it possible to quantify the influence of such factors as reservoir and bottomhole pressures, filtration resistance coefficients, on the deviation of gas flow rate. Further ranking of wells by factors constitutes the basis for managing gas withdrawal (injection) processes and for well interventions planning.
A step-by-step approach to creating and tuning PVT-models of reservoir hydrocarbon systems based on the state equation
Authors: Yushchenko Taras S. , Brusilovsky Alexander I.
Published: October 2022

The article is considering a new effective step-by-step approach to creating and tuning PVT-models of reservoir oil and reservoir gas condensate mixtures. The method is based on the reproducing of the results of field measurements and basic laboratory studies of representative samples in thermodynamic modeling using cubic three parameters equation of state. Tuning PVT-model is used for reliable modeling of PVT properties of reservoir fluids (reservoir oil and reservoir gas) in the design and monitoring of field development, calculation of multiphase flow in wells and field pipelines, as well as in basin modeling.

Proposed approach makes possible to tune the PVT model with high accuracy of both reservoir oil and reservoir gas condensate system to experimental data using a step-by-step procedure, where at each step, by changing one of the parameters of the equation of state, one of the PVT properties of the hydrocarbon system is tuned. Algorithmization and automated application of this approach in specialized software products is possible.

Proposed approach allows tune reservoir oil PVT-models on the main PVT-properties such as saturation pressure, FVF, STO density, gas-oil ratio of reservoir oil and dependencies of dynamic viscosity and compressibility on pressure at reservoir temperature as well as STO density. The tuned gas-condensate PVT-model precisely reproduces the key properties such as dew point pressure, initial condensate content in the reservoir gas, z-factor of the reservoir gas, gas-oil ratio, stable condensate density, drop down curve by the result of CVD-test.

PVT-models created on the base of the proposed method, provide reliable information on the properties of a reservoir fluid in development of flow simulation both using a reservoir simulation compositional models and using pseudo models “black oil”.
The method is illustrated by the example of creation of the adequate PVT-models of various regions of Russia reservoir oil and reservoir gas condensate mixtures.