bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease
Authors: Ban Woo Ho , Rhee Chin Kook
Published: March 2022

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)–antioxidant response element (ARE) is a representative system. Dysregulation of the Nrf2-ARE pathway is responsible for the development and promotion of COPD. Furthermore, COPD severity is also closely related to this pathway. There has been a clinical impetus to use Nrf2 for diagnostic and therapeutic purposes. Therefore, in this work, we systematically reviewed the clinical significance of Nrf2 in COPD patients, and discuss the value of Nrf2 as a potential COPD biomarker.
Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Wafa Ifan Ali , Pratama Nando Reza , Sofia Nurizzah Farahiyah , Anastasia Elsha Stephanie , Konstantin Tiffany , Wijaya Maharani Ayuputeri , Wiyono M. Rifqi , Djuari Lilik , Novida Hermina
Published: March 2022

Background: Abrupt implementation of lockdowns during the coronavirus disease 2019 (COVID-19) pandemic affected the management of diabetes mellitus in patients worldwide. Limited access to health facilities and lifestyle changes potentially affected metabolic parameters in patients at risk. We conducted a meta-analysis to determine any differences in the control of metabolic parameters in patients with diabetes, before and during lockdown.Methods: We performed searches of five databases. Meta-analyses were carried out using random- or fixed-effect approaches to glycaemic control parameters as the primary outcome: glycosylated hemoglobin (HbA1c), random blood glucose (RBG), fasting blood glucose (FBG), time-in-range (TIR), time-above-range (TAR), time-below-range (TBR). Mean difference (MD), confidence interval (CI), and P value were calculated. Lipid profile was a secondary outcome and is presented as a descriptive analysis.Results: Twenty-one studies enrolling a total of 3,992 patients with type 1 or type 2 diabetes mellitus (T1DM or T2DM) were included in the study. Patients with T1DM showed a significant improvement of TIR and TAR (MD=3.52% [95% CI, 0.29 to 6.74], I2=76%, P=0.03; MD=–3.36% [95% CI, –6.48 to –0.25], I2=75%, P=0.03), while FBG among patients with T2DM significantly worsened (MD=3.47 mg/dL [95% CI, 1.22 to 5.73], I2=0%, P<0.01). No significant difference was found in HbA1c, RBG, and TBR. Use of continuous glucose monitoring in T1DM facilitated good glycaemic control. Significant deterioration of lipid parameters during lockdown, particularly triglyceride, was observed.Conclusion: Implementation of lockdowns during the COVID-19 pandemic did not worsen glycaemic control in patients with diabetes. Other metabolic parameters improved during lockdown, though lipid parameters, particularly triglyceride, worsened.
Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis
Authors: Zhang Tianqi , Shaw Marnie , Cherbuin Nicolas
Published: March 2022

Background: Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.Methods: PubMed, PsycInfo and Cochrane Library were searched for brain imaging studies reporting on brain volume differences between individuals with T2DM and healthy controls. Data were examined using meta-analysis, and association between age, sex, diabetes characteristics and brain volumes were tested using meta-regression.Results: A total of 14,605 entries were identified; after title, abstract and full-text screening applying inclusion and exclusion criteria, 64 studies were included and 42 studies with compatible data contributed to the meta-analysis (n=31,630; mean age 71.0 years; 44.4% male; 26,942 control; 4,688 diabetes). Individuals with T2DM had significantly smaller total brain volume, total grey matter volume, total white matter volume and hippocampal volume (approximately 1% to 4%); meta-analyses of smaller samples focusing on other brain regions and brain atrophy rate in longitudinal investigations also indicated smaller brain volumes and greater brain atrophy associated with T2DM. Meta-regression suggests that diabetes-related brain volume differences start occurring in early adulthood, decreases with age and increases with diabetes duration.Conclusion: T2DM is associated with smaller total and regional brain volume and greater atrophy over time. These effects are substantial and highlight an urgent need to develop interventions to reduce the risk of T2DM for brain health.
Central Venous Access in Neonates
Authors: Saber Hosam I. El Said , Farid Ahmed M. , Wafa Tamer A. , Taman Hani I.
Published: March 2022

Background:

In neonates, percutaneous central venous catheter (CVC) insertion is often a challenging technique. Recent reports have reported the efficacy of ultrasound (US) guidance when performing such an intervention. We conducted this study to compare US-guided and minimal surgical CVC insertion regarding time and ease of insertion, reliability, and complications.

Patients and Methods:

This prospective randomized study included 92 neonates scheduled for CVC insertion. They were divided into two groups: Group A (46 neonates) underwent the US-guided approach and Group B (46 neonates) underwent the surgical approach. The number of attempts and the duration of the procedure were documented in both groups. In addition, intraoperative and postoperative complications were recorded.

Results:

Each of patient's age, gender, weight, and the indication of catheter insertion were statistically comparable between the two groups. The number of trials showed a significant increase in Group A (1.52 vs. 1.07 in Group Bp <0.001). Nevertheless, the time of the procedure was significantly decreased in the same group (3.68 vs. 10.21 in Group Bp <0.001). Table 2 summarizes the previous findings. Failure was encountered only in one case in Group A (2.2%), which was converted to the open surgical technique. In general, the incidence of complications showed no significant difference between the two approaches.

Conclusion:

Although US-guided CVC insertion is associated with an increased number of trials, the duration of the procedure is significantly diminished with its use. Furthermore, it has a high success rate in addition to a comparable complication profile with the traditional surgical method.
Ultrasound Block of the Medial Branch
Authors: Putzu Marta , Marchesini Maurizio
Published: March 2022

Background:

Blocking the medial branch of the lumbar facet joints plays a fundamental diagnostic and therapeutic role in the treatment of lumbar pain. Attempts to replace the typical guided X-ray techniques with ultrasound-guided techniques have also involved treating the lumbar medial branches. By applying the cumulative sum control chart (CUSUM method), we sought to evaluate the learning curve associated with ultrasound-guided block of the lumbar medial branches in operators experienced in locoregional anesthesia but without expertise in pain therapy.

Aim:

This study aimed to use a repeatable method to identify the learning curve of the ultrasound-guided medial branch block.

Settings and Design:

This study was a prospective application of over forty consecutive procedures of ultrasound lumbar medial branch block.

Materials and Methods:

The ultrasound medial branch blocks were performed under ultrasound guidance with confirmation of correct positioning using fluoroscopy on a population of patients with low back pain with any body mass index (BMI).

Statistical Analysis:

The operator's performance was assessed using the learning curve cumulative summation test (LS-CUSUM).

Results and Conclusions:

The correct target was reached in 29 procedures out of a total of 40 (72.5%) and in 29 out of 36 procedures performed on patients with BMI <30 (80.5%). According to the CUSUM algorithm, 11 further consecutive successes would have been necessary (47 procedures in total) to achieve a proven learning of the technique in the group with only patients with a BMI <30, with a further 22 consecutive successes (62 procedures in total) in the general group. Ultrasound-guided block of the lumbar medial branch appears not to be optimal for training beginner/intermediate operators seeking to replace guided X-ray procedures with guided ultrasound.
Microdeletions and vertical transmission of the Y-chromosome azoospermia factor region
Authors: Deng Chen-Yao , Zhang Zhe , Tang Wen-Hao , Jiang Hui
Published: March 2022

Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region of the long arm of the Y chromosome, the azoospermia factor region (AZF). AZF microdeletions are the main structural chromosomal abnormalities that cause male infertility. Assisted reproductive technology (ART) has been used to overcome natural fertilization barriers, allowing infertile couples to have children. However, these techniques increase the risk of vertical transmission of genetic defects. Despite widespread awareness of AZF microdeletions, the occurrence of de novo deletions and overexpression, as well as the expansion of AZF microdeletion vertical transmission, remains unknown. This review summarizes the mechanism of AZF microdeletion and the function of the candidate genes in the AZF region and their corresponding clinical phenotypes. Moreover, vertical transmission cases of AZF microdeletions, the impact of vertical inheritance on male fertility, and the prospective direction of research in this field are also outlined.
Ameloblastic Fibro-Odontoma
Authors: Sanjai Karpagaselvi , Reddy Lokesh Papiah , Roopavathi Keshavaiah , Muniswamy Harish Kumar
Published: March 2022

A 19-year-old male patient reported to dental OPD of our institution with a swelling in the posterior part of the mandible on the left side. The patient gave a history of gradual increase in the size of swelling for 7 years. The patient also had a radiograph and histopathology slides from his previous dental visit at another facility. The radiograph revealed a well-circumscribed radiolucency with an impacted tooth (38). Histopathology slides showed features of an ameloblastic fibroma (AF). The patient had deferred the treatment for 5 years since he was young and reported to our OPD due to increase in the size of the swelling over the past few weeks. The present radiographs revealed radiolucency with radiopacity. Excisional biopsy was performed and the histopathological examination revealed an Ameloblastic fibro odontoma. This case report is to document and highlight the possible progression of AF to Ameloblastic fibro-odontoma.
The clinical challenges and dilemma in the management of uncommon maxillary sinus tumors − A report of two cases
Authors: Jain Siddhanth , Thiagarajan Shivakumar , Panjwani Poonam , Sathe Pranav , Ramadwar Mukta
Published: March 2022

Maxillary sinus is the common site for the nose and paranasal sinus tumors with diverse histopathological types and the treatment for each may differ. Making a histopathological diagnosis on occasion can be challenging. We had two patients presenting with upper alveolus growth in whom establishing the histopathological diagnosis was challenging. Through clinical evaluation, imaging (computed tomography and/or magnetic resonance imaging) and identification of key histopathological features helped in the management of these patients.
Marsupialization of odontogenic keratocyst using thermoform surgical splint in a pediatric patient, with 3-year follow-up
Authors: Nallanchakrava Srinivas , Manoj Kumar Mallela George , Animireddy Dwitha , Manasa Garikina
Published: March 2022

Odontogenic keratocyst (OKC), also known as keratocystic odontogenic tumor, is categorized as one of the developmental epithelial cysts, which accounts 10%–20% of all cystic lesions in jaws. Considering its high recurrence rate, combative treatment modalities such as enucleation and jaw resection are suggested. This case report aims to emphasize clinical, radiological and histological overview of OKC with conservative approach marsupialization using thermoform surgical splint in a 9-year-old female patient with no recurrence at 3-year follow-up.
Hypohidrotic ectodermal dysplasia
Authors: Bagdey Shubhangi P. , Moharil Rohit B. , Dive Alka , Bodhade Ashish
Published: March 2022

Ectodermal dysplasia represents a group of inherited conditions in which two or more ectodermally derived anatomical structures fail to develop resulting in most notably anhidrosis/hypohidrosis, hypotrichosis and hypodontia. It is a xlinked recessive disorder with male predominance. We report a classical case in a 17-year-old male with emphasis on review of literature and latest updates.
Ewing's sarcoma of the mandible with multilocular radiolucency
Authors: Mishra Mithilesh Narayan , Patil Pavan , Chandavarkar Vidyadevi , Bhargava Deepak
Published: March 2022

Ewing's sarcoma (ES) is a small blue round cell tumor, malignant in nature typically affecting long bones and pelvis. Occurrence of ES in the head and neck region is rare and is reported to be 2%–3%, of which the chances of having primary lesion are rare. In the head and neck region, it has been reported to strike skull, supraclavicular region, parotid region, orbital floor, nasal cavity, maxilla, mandible and zygoma. We present a case of primary ES of the mandible in a 22-year-old female who reported with a palpable swelling on the lower left part of the face; and intraorally, there was a growth in the molar region. Orthopantomogram showed multilocular radiolucency in the molar–ramus region. The diagnosis was made after surgical resection, histopathology and immunohistochemistry profiling. The patient was treated by cortical segmental resection of mandible combined with chemotherapy and a follow-up was done for 2 years.
Inflammatory myofibroblastic tumor of anterior maxillary gingiva
Authors: Goyal Lata , Rao Shalinee , Reddy Gosla Srinivas , Agarwal Padmanidhi
Published: March 2022

Inflammatory myofibroblastic tumor (IMT) is a rare benign neoplasm with variable clinical presentation. We hereby present a case of a 27-year-old female who presented to us with an unsuspecting gingival overgrowth in her anterior gingiva. This article aims to describe IMT as a rare intraoral entity which may involve the anterior maxillary gingiva, involving or sparing the underlying bone, as only a handful of such cases have been reported so far. Surgical excision is the mainstay of treatment. Biopsy and histopathological examination of even the smallest lesions is a must. Timely diagnosis and intervention can prevent severe morbidity that can arise if these lesions are left undiagnosed as aggressive management of lesions that become extensive is mandatory.
Bilateral ectopic third molars in maxillary sinus associated with dentigerous cyst identified with ophthalmic, nasal and maxillary complication
Authors: Arici Merve , Bayar Tolga , Tas-Ozyurtseven Betul , Gungormus Metin
Published: March 2022

Etopic tooth eruption is the occurrence of the tooth germ in a nonanatomical position. It can be associated with dentigerous cyst, which is the second most seen in the development of odontogenic cyst commonly presented in mandibular region and seen in single form. It is usually accompanied with mandibular third molar followed by canine. Bilateral and multiple dentigerous cysts in nonsyndromic patients are fairly rare phenomenon and barely documented in the literatüre. We report a rare case of bilateral dentigerous cysts associated with ectopic third molars in the maxillary sinuses. Computerized tomography scan confirmed the diagnosis. A 32-year-old female patient manifesting as postnasal discharge accompanied with chief complaint of nasal obstruction, pain at blinking right eye from pressure of cyst at the inferior orbital rim, and headache for the last 1 year. This report presented our management of rarely seen case of bilateral dentigerous cysts related with ectopic third molars in maxillary sinuses. Ectopic teeth eruption in maxillary sinus should be treated as early as possible once it is diagnosed, in consideration of related complication of orbital and nasal involvement. The symptoms totally recovered with the suitable management method for our patient. The prevalence of maxillary third molars ectopic eruption in the maxillary sinus (Antrum of Highmore) is extremely rare in the literature. Lack of treatment protocol for such ectopic eruptions in the maxillary sinus and its rareness deserved to be added to the literature.
Ameloblastic carcinoma
Authors: Manchanda Adesh S , Narang Ramandeep S , Nagi Ravneet S
Published: March 2022

Malignant odontogenic neoplasms are extremely challenging to study due to their rarity and variable clinical presentations. Ameloblastic carcinoma (AC) is one such odontogenic tumor which has been the subject of controversy, in part because of its scarcity, complicated by confusion in terminology along with complexity in classification. Histologic features of AC resemble tumor cells of ameloblastoma but exhibit cellular atypia. Surgical resection for this kind of lesion, leaving at least a 2 cm free margin coupled with neoadjuvant radiotherapy, might prove fruitful results. The current paper reports a case of an extraosseous variant of AC which posed a diagnostic challenge due to variable presentations histopathologically, suggesting the need for evidence-based case studies and molecular workup for a better therapeutic and prognostic insight.
Epithelial-myoepithelial carcinoma ex pleomorphic adenoma of the parotid gland with unique histologic differentiation
Authors: Nandini Doddabasavaiah Basavapur , Singh Wahengbam Tulsidas , Aparnadevi Potsangbam , Ningombam Deepak Singh
Published: March 2022

Epithelial myoepithelial carcinoma (EMC) is an uncommon low-to-intermediate grade salivary gland malignancy that accounts for 1% of all tumors arising in salivary glands. About 80% of these tumors affect the parotid gland. These lesions either arise de novo or from existing pleomorphic adenoma (PA). Histologically, these tumors reveal a biphasic cell population with inner ductal epithelial cells and peripheral myoepithelial cells. There are many histologic variants of EMC, but sebaceous, verocay-like differentiation and high-grade transformation is very rarely reported. This article describes a 48-year-old female patient diagnosed with EMC ex PA with unique histologic differentiation.
Oral squamous cell carcinoma in coca chewers from a north region of Argentina
Authors: Molina-Ávila Ignacio , Rojas Andrea Arellano , Gilligan Gerardo , Cordero-Torres Karina
Published: March 2022

Chewing coca leaves is a habit still practiced in Bolivia, Peru and Argentina. There is scarce evidence in the relationship between this habit and development of oral squamous cell carcinoma (OSCC), some authors have found oral epithelial changes in coca chewers. This study aimed to present a case series of patients with a coca chewing habit that developed OSCC, in the absence of risk factors for oral cancer. Patients were evaluated in Hospital Señor del Milagro, Salta, Argentina. None of them had a relevant morbid history and presented intraoral tumors, with an ulcerated surface on the gingivobuccal complex. Coca chewing habit was recorded in all cases. Present cases could start discussions and new lines of researches focusing on the habit of coca leaves chewing as a risk factor for OSCC. It would be very useful to know the underlying mechanisms between this habit and a possible role in oral carcinogenesis.
Benign mesenchymal odontogenic tumors of the maxillofacial bones
Authors: Berberi Antoine N , Aoun Georges T , Aad Georges P , Khalaf Emile N
Published: March 2022

Benign mesenchymal odontogenic tumors are lesions derived from the mesenchymal components of the tooth-forming apparatus and are consequently found within the jawbone. Benign fibro-osseous tumors are part of this category of lesions in which normal bone is substituted, initially by fibrous tissue and within time become infiltrated by osteoid and cementoid elements. They are asymptomatic, slow-growing lesions and remain undiagnosed until swelling of the face becomes prominent and they share similar radiological characteristics. Herein, we report three cases of ossifying fibroma, cemento-osseous fibroma and periapical cemento-osseous dysplasia and analyze all the correlating factors, clinical history, radiological and histological features, intraoperative appearance, and treatment with a 3-year follow-up period. Despite the advances in the identification of these pathologies, clinicians still face difficulties in their classification and the diagnosis due to overlap in both histological and radiographic findings. An accurate final diagnosis is essential for appropriate treatment and an informative prognosis.
Об интерполяционной теореме Марцинкевича-Кальдерона для интегральных операторов
Authors: Nursultanov Erlan Dautbekovich , Tleukhanova Nazerke Tulekovna , Mukeyeva Z M
Published: March 2022

Рассматривается обратная задача к классической интерполяционной теореме
Марцинкевича-Кальдерона. В терминах ядра интегрального оператора получены
необходимые условия для того, чтобы для этого оператора имело место утверждение
теоремы Марцинкевича-Кальдерона. Показано, что эти условия являются достаточными,
чтобы данный интегральный оператор был $(p,q)$-сильного типа для тех же
параметров $p$ и $q$, что указанны в интерполяционной теореме.
Библиография: 8 названий.
Hearing screening outcomes in pediatric critical care survivors: a 1-year report
Authors: Suwannatrai Pattita , Chaiyakulsil Chanapai
Published: March 2022

Background: Hearing loss is a potentially serious complication that can occur after surviving a critical illness. Study on screening for hearing problems in pediatric critical care survivors beyond the neonatal period is lacking. This study aimed to identify the prevalence of abnormal hearing screening outcomes using transitory evoked otoacoustic emission (TEOAE) screening in children who survived critical illness and to find possible associating factors for abnormal hearing screening results.Methods: This study was a single-center, prospective, observational study. All children underwent otoscopy to exclude external and middle ear abnormalities before undergoing TEOAE screening. The screening was conducted before hospital discharge. Descriptive statistics, chi-square, and logistic regression tests were used for data analysis.Results: A total of 92 children were enrolled. Abnormal TEOAE responses were identified in 26 participants (28.3%). Children with abnormal responses were significantly younger than those with normal responses with a median age of 10.0 months and 43.5 months, respectively (P<0.001). Positive association with abnormal responses was found in children younger than 12 months of age (adjusted odds ratio [OR], 3.07; 95% confidence interval [CI], 1.06–8.90) and children with underlying genetic conditions (adjusted OR, 6.95; 95% CI, 1.49–32.54).Conclusions: Our study demonstrates a high prevalence of abnormal TEOAE screening responses in children surviving critical illness, especially in patients younger than 12 months of age. More extensive studies should be performed to identify the prevalence and associated risk factors of hearing problems in critically ill children.
Analyzing NAS1675 Vibration Endurance Test using Accelerometers
Authors: Huang Junjie
Published: March 2022

The endurance test described in NAS1675 section 4.6.7 option 1, more commonly known in the fastener industry as the “boomer banger test”, has been a commonly accepted test to examine the vibration endurance of fasteners since its approval in 1964. This paper seeks to provide a better understanding of the vibration characteristics of this test apparatus by using accelerometers attached directly to the test plate. Details from this test were analyzed for possible ambiguous setup factors which were not well defined in the specification. Those factors were then used to evaluate their effect on the test. The results from the evaluation indicates that the inherent variations are larger than what the setup factors could produce. The data obtained from the accelerometers shows the test to be closer to a repetitive shock test, with large variation in G-force measured by the accelerometers.
Approach for Digitalization of Maintenance Processes within the Aircraft Cabin
Authors: Hintze Hartmut , Giertzsch Fabian , Kusch Alexander , God Ralf
Published: March 2022

Enhancing the comfort for passengers, airlines are constantly increasing the number of services within the aircraft cabin such as meal ordering directly from passenger seats. The payment and menu selection can be completely processed by means of a passenger-individual airline user account also considering the remaining inventory of the galley. The implementation of such type of services is supported by digitalization of cabin business processes. For these new services the airline requires a high availability of the process-related system functions to ensure airline’s revenue and customer satisfaction.

A possible approach to reach the target of high availability of these functions is to use the trend of digitalization for improving function-relevant maintenance processes within the aircraft cabin. This requires an introduction of flexible communication architectures to enhance the existing maintenance process by establishing an automated fault detection, root cause analysis, and/or even fault prediction. For implementation it is necessary to provide system data and parameters digitally, e.g. by sensor measurements or an online evaluation of already existing system data logs. An example is the working light within the aircraft galley used to create an appropriate working environment for the cabin crew to prepare ordered meals for the passengers. Currently, fault detection is only possible by identifying its failure effect, i.e. a not illuminating lighting unit. However, by measuring the current consumption of the light source via a digital sensor, it would be possible to detect a changing trend in the current consumption and, in turn, triggering a maintenance task to replace the light before it actually fails. The evaluation of such current measurement with the resulting fault prediction would expand the maintenance system by a new function.

This paper describes how digitally supportable maintenance processes for any cabin system can be systematically identified and which system modifications are necessary for realization. Further-more, a methodology for cost and benefit assessment is introduced to find the right level of digitization for the cabin system under analysis.
Impact of Stator Segmentation on the Performance of Aerospace Propulsion Machines
Authors: Ramanathan Mathavan Jeyabalan Ram Kumar , Vakil Gaurang , Gerada David , Gerada Chris , Minshull James
Published: March 2022

Electric machines offering a high power density are required for aerospace applications. Soft magnetic material with a high saturation flux density is one of the key component which is required to realize these power density targets. The need for a high saturation flux density necessitates the use of cobalt iron lamination over the conventional silicon steel. However, cobalt iron is very expensive i.e. order of 10 in comparison to silicon steel. Stator segmentation is identified as an appropriate method to reduce the wastage and cost associated with lamination. Consequently, in this paper, stator segmentation is analyzed on a 1.35 MW, 16-pole 48-slot propulsion machine. The impact of manufacturing is accounted by controlling the resulting airgap between the segmented structures. Electromagnetic performance for various segmented topologies are compared in terms of torque, torque ripple, and iron loss. Average torque is found to degrade by nearly 10% with an increase in the number of stator segments and the thickness of resulting airgap. Therefore, a tight tolerance is required between the segmented parts to retain the electromagnetic performance. On the other hand, this increases the cost of fabrication and nullifies the benefits offered by stator segmentation.
Organ donation after circulatory death as compared with organ donation after brain death in Switzerland – an observational study
Authors: Elmer Andreas , Rohrer Mara-Lisa , Benden Christian , Krügel Nathalie , Beyeler Franziska , Immer Franz F
Published: March 2022

AIMS OF THE STUDY: Organ donation after circulatory death (DCD) was reintroduced in Switzerland in 2011 and accounts for a third of deceased organ donors today. Controversy persists if DCD transplants are of similar quality to transplants following donation after brain death (DBD), mainly due to warm ischaemia time DCD organs are exposed to. We compared DCD with DBD in Switzerland.
METHODS: Data on deceased adults who were referred to and approved for organ donation from 1 September 2011 to 31 December 2019 were retrospectively analysed (217 DCD, 840 DBD donors). We compared DCD and DBD donor/organ characteristics, transplant rates of lungs, liver, kidneys, and pancreas, and early liver and kidney graft function in the recipient. The effect of DCD/DBD on transplant rates (organ transplanted or not) and 72-hour recipient graft function (moderate/good vs delayed graft function / organ loss) was analysed using multivariable logistic regression. Among utilised DCD donors, we analysed the effect of functional warm ischaemia time (FWIT) and donor age on 72-hour post-transplant liver and kidney graft function, also using multivariable logistic regression.
RESULTS: DCD donors were more often male (64.5% vs 56.8% p = 0.039), presented with heart disease (36.4% vs 25.5%, p <0.001), were resuscitated before hospital admission (41.9% vs 30.7%, p = 0.006), and died from anoxia (41.9% vs 23.9%). Kidney function before transplantation was comparable, lung, liver and pancreas function were poorer in DCD than DBD. Eighty-one and 91% of approved DCD and DBD donors were utilised (p <0.001). Median FWIT in DCD was 29 minutes (interquartile range 25–35). DCD transplant rates ranged from 4% (pancreas) to 73% (left kidney) and were all lower compared with DBD. Seventy-two-hour liver graft function was comparable between DCD and DBD (94.2% vs 96.6% moderate/good, p = 0.199). DCD kidney transplants showed increased risk of delayed graft function or early organ loss (odds ratios 8.32 and 5.05; 95% confidence intervals CI 5.28–13.28 and 3.22–7.95; both p <0.001, for left and right kidney transplants, respectively). No negative effect of prolonged FWIT or higher donor age was detected.
CONCLUSION: Despite less favourable donor/organ characteristics compared with donation after brain death, donation after circulatory death donors are increasingly referred and today provide an important source for scarce transplants in Switzerland. We identified a higher risk for delayed graft function or early organ loss for DCD kidney transplants, but not for DCD liver transplants. When carefully selected and allowed for other risk factors in organ allocation, prolonged functional warm ischaemia time or higher age in donation after circulatory death does not seem to be associated with impaired graft function early after transplantation.
Rozwój wczesnych biologicznych metod leczenia schizofrenii po II wojnie światowej
Authors: Gholamy Mateusz
Published: March 2022

Development of early biological methods of treatment of schizophrenia after the II World War

The article tells about the history of development the fi rst biological methods of treatment of schizophrenia, introduced after the II World War. At fi rst, there was insulin shock therapy, introduced for the fi rst time in 1933, then electroconvulsive therapy, applied in 1938 and lobotomy, which became popular method of treatment in 40s and 50s. Introducing every of this methods was an important step in schizophrenia research, altough all of them were mainly ineffective. Moreover all of this methods contain many side effects, even dangerous to life. It seems that development of each of this methods was crucial step important to introduce much more effective and safety ways of treatment of this disease.
Koncepcja świętości w noweli Pauli von Preradović pt. Die Versuchung des Columba
Authors: Sobczak Michael
Published: March 2022

Dorobek literacki Pauli von Preradović stanowią głównie wiersze, w tym teksty do hymnu narodowego Austrii Land der Berge, Land am Strome (1946/1947), pisarka ma też na koncie kilka nowel, szkice autobiograficzne, drobne utwory sceniczne i teksty publicystyczne, a także jedną powieść. Niniejszy artykuł bada koncepcję świętości w noweli Preradović Die Versuchung des Columba. Święty Kolumban, bohater noweli, był irlandzkim opatem i misjonarzem. Dziś jest pamiętany jako katolicki święty i jeden z Dwunastu Apostołów Irlandii. Niniejsza analiza koncentruje się na charakterze Kolumbana, jego zachowaniu, działaniach, rozwoju oraz etapach psychologicznych, przez jakie przeszedł. Preradović tłumaczy swoją koncepcję świętości na przykładzie życia Kolumbana. Nie definiuje świętości jako nieomylności, ale przede wszystkim jako integralność i poczucie odpowiedzialności za bliźnich. Autorka opisuje ją jako cnotę, dzięki której wszystkie swoje czyny podporządkowuje się Bogu. Zalicza ją do natchnionych cnót moralnych.

The Conception of Holiness in Paula von Preradović’s Novella Die Versuchung des Columba [The Temptation of Saint Columba]

Paula von Preradović’s literary output consists mainly of poems, including the lyrics for the national anthem of Austria, Land der Berge, Land am Strome [Land of the mountains, land on the river] (1946/1947), but she also wrote several novellas, autobiographical sketches, small scenic works and journalistic texts, as well as one novel. This article investigates the conception of holiness in Preradović’s novella Die Versuchung des Columba. Saint Columba, the protagonist of the novella, was an Irish abbot and missionary. He is remembered today as a Catholic saint and one of the Twelve Apostles of Ireland. The analysis focuses on the character of Columba, his behaviour, actions, development and the psychological stages he has gone through. Preradović explains her conception of holiness with the example of Columba’s life. She does not define holiness as infallibility, but primarily as integrity and a sense of responsibility for fellow men. The author describes it as that virtue by which one makes all one’s acts subservient to God. She ranks it among the infused moral virtues.
Kompetencje organów nadzoru budowlanego wobec obiektów budowlanych niewymagających decyzji o pozwoleniu na budowę lub zgłoszenia
Authors: Sypniewski Dominik
Published: March 2022

Competencies of construction supervision authorities over building objects that do not require a building permit or notification

The content of this article discusses the issue of control and supervision of the construction process with regard to construction units that have been fully excluded from ex ante rationing by architectural and construction administration authorities, i.e. they do not require a building permit or notification. The aim of the discussion is to indicate that such construction units are subject to control and supervision performed by the construction supervision authorities during the course of the construction works and during the operational use of the construction unit.
COVİD-19 SALGINININ TÜRKİYE'DE FİNANSAL DEĞİŞKENLER ÜZERİNDEKİ ETKİSİNİN EKONOMETRİK ANALİZİ
Authors: PEHLİVAN Ceren , TOSUN Nergis , HAN Ayşegül
Published: March 2022

Çin’in Wuhan kentinde ilk olarak görülen Covid-19 zaman içerisinde bütün dünyaya etki ederek büyük çaplı bir salgın durumuna ulaşmıştır. Salgın sonrasında dünya ekonomileri birçok problemle karşı karşıya kalmıştır. Yaşanan gelişmeler nedeniyle Covid-19 ve Covid-19’un etkileri üzerine birçok araştırma yapılmıştır. Bu çalışmada da Türkiye’de Covid-19 toplam vaka sayısının BİST-100 endeksi, döviz kuru ve gram altın fiyatları üzerindeki etkisi incelenmiştir. 11.03.2020-22.12.2021 dönemi günlük verilerine durağanlığı incelemek amacıyla Fourier KPSS birim kök testi yapılmıştır. Değişkenler arasındaki eşbütünleşme ilişkisi ise Fourier Shin eşbütünleşme analiziyle incelenmiştir. Fourier Shin eşbütünleşme testi sonucunda toplam vaka sayısı ve BİST-100 endeksi arasında ilişki olduğu bulgusuna ulaşılırken, gram altın ve kur ile toplam vaka sayısı arasında ilişki tespit edilememiştir. Çalışmanın son olarak yapılan Fourier nedensellik testi sonucunda ise BİST-100 ile toplam vaka sayısı arasında çift yönlü; toplam vaka sayısından kur ve grama doğru ise tek yönlü nedensellik ilişkisi olduğu saptanmıştır.
The role of the Protestant legacy in shaping Lower Silesian cultural heritage as exemplified by the refuge church in Borek Strzeliński (Großburg)
Authors: Łach Janusz , Krzemińska Alicja , Widawski Krzysztof , Zaręba Anna
Published: March 2022

Protestant refuge churches were built in Silesian Protestant principalities, and in the borderline areas of Saxony, Brandenburg and Poland before the end of Thirty Years’ War and the signing of the Peace of Westphalia. In the most part, the churches were erected by means of adapting Catholic churches to the needs of Protestant believers, e.g. by building emporas (choir galleries), a pulpit and an altar inside the church. The acquisition of churches in Silesia was peaceful, without any violence almost everywhere, and it was not a rare phenomenon that a single church was used by two religions at the same time. At the end of the eighteenth century, there were approximately 110 refugee churches in Silesia. Currently, there are no churches of this type in Lower Silesia, and their extraordinary decoration was preserved in only a few of them. The main aim is to analyse this specific, forgotten sacral Protestent heritage, i.e. refuge churches in Lower Silesia, from the historical, sociological and architectural perspective. The main objective is to focus on the historical importance of the refuge churches in Lower Silesia – restoring identity as exemplified by the church in Großburg (Polish: Borek Strzeliński), analyse the degree to which the Protestant cultural legacy was preserved in the material rural architecture of Großburg and analyse the acceptance of the Evangelical heritage in the mentality of the local community.
El lugar del Cuerpo y su impacto en las sesiones de psicoterapia con modalidad virtual: Desafíos de la Psicoterapia virtual con orientación psicoanalítica
Authors: Andrade-Castro José Abelardo , Egas-Reyes Verónica
Published: March 2022

El presente artículo hace una revisión teórico – conceptual, sobre el lugar del cuerpo en las sesiones de psicoterapia virtual. Para este fin se hace una revisión bibliográfica de diversos textos, artículos y documentos con relación en primera instancia con los antecedentes históricos del cuerpo como objeto de estudio desde distintos campos de las ciencias psicológicas y el psicoanálisis; posteriormente se hace una reseña de los postulados más relevantes desde la teoría psicoanalítica de Jacques Lacan, señalando los tres registros del psiquismo: lo real, lo simbólico y lo imaginario, para desde esta perspectiva poder comprender el lugar que tiene el cuerpo más allá de un discurso biomédico. Por otra parte, se describe, cómo los fenómenos transferenciales se manifiestan en las sesiones de psicoterapia en el campo de lo virtual debido a la presencia virtual del cuerpo del psicoterapeuta. Para finalizar se reseña las diversas opiniones de psicólogos y psicoanalistas, con artículos de referencia sobre el impacto que genera en las sesiones de psicoterapia virtual, la ausencia de lo presencial del cuerpo, y cómo esta forma de vincularse, influye en la dinámica de la psicoterapia. Este artículo resalta cómo esta dinámica de la presencia - ausencia del cuerpo físico en las sesiones de psicoterapia virtual de orientación psicoanalítica puede llegar a impactar en el procedimiento psicoterapéutico.

Palabras clave: cuerpo, psicoanálisis, virtual, tecnología, psicoterapia.
Identificación de trastornos mentales presentes en mujeres embarazadas en la ciudad de Rocafuerte
Authors: Gómez-Reyna Robert Rafael , Valdivieso-López Isabel Patricia
Published: March 2022

Existen diversas investigaciones en las que demuestran múltiples factores de riesgo en las diferentes etapas del embarazo, los cuales influyen en el curso y aparición de los trastornos mentales. El objetivo es determinar la relación de los trastornos mentales en las mujeres embarazadas. Por lo cual se realiza un estudio desde el enfoque cuantitativo descriptivo, con tipo de diseño transversal. El universo corresponde a todas las mujeres embarazadas atendidas por control en el Hospital Básico Natalia Huerta de Niemes del Cantón Rocafuerte- Manabí. La muestra se obtuvo de la población de mujeres embarazadas atendidas en el hospital durante un trimestre. Se realizó la evaluación mediante la información de las fichas de las pacientes ingresadas a más de la aplicación del Cuestionario de Síntomas "Self-Reporting Questionnaire” (SRQ). Para el procesamiento de datos, se utilizó el software estadístico SPSS. La aplicación de psicoterapia es trascendental en el tratamiento a múltiples problemas de salud mental y su identificación e intervención temprana puede contribuir a un mejor manejo de estos cuadros clínicos. Se evidenció una prevalencia de antecedentes psico-sociales en las purpurea, con un alto índice de alteraciones de salud mental tales como ansiedad y depresión.

Palabras clave: factores de riesgo, embarazo, alteraciones mentales, gestantes, salud mental.
The Acquirement of a European Dimension in Education
Authors: Răileanu Βrânduşa Prepeliţă
Published: March 2022

In a complex world, characterized by diversity and change, acquiring a European dimension in education answers the challenges of the open society. The paper describes the Romanian government's strategy to attempt this dimension in higher education. Attention is drawn to the technical universities in terms of the access to higher education and the transition to an educational system appropriate for a society based on individual freedom, political pluralism, and market economy. It is emphasized that in the context that is specific to Romania, where fighting marginalization, social and cultural discriminations is a process that has recently started, this orientation could offer compensatory solutions.
ADI Methods for Three-dimensional Fractional Diffusions
Authors: Concezzi Moreno , Spigler Renato
Published: March 2022

ADI methods can be generalized to solve numerically multidimensional fractional diffusion equations, which describe fluid flows through porous media better than classical diffusion equations. A new, unconditionally stable, second-order and well balanced in space, third-order in time ADI scheme has been constructed and its convergence accelerated by an extrapolation technique coupled with the PageRank algorithm.
Fotovoltaik Panel Yüzey Sıcaklığının Denizli İli için Çıkış Gücü ve Verim Üzerindeki Etkisinin İncelenmesi
Authors: GÜVEN Şengül
Published: March 2022

Günümüzde sürekli artan enerji ihtiyacı ve bu enerji ihtiyacının ülkemizde çoğunlukla dışa bağımlı kaynaklardan karşılanması, hem ekonomik hem de çevresel etkiler açısından olumsuzluklara yol açmaktadır. Yenilenebilir enerji kaynaklarından güneş, iyi bir güneş enerji potansiyeline sahip ülkemizde ilk akla gelen kaynak olmasına rağmen elektrik üretimindeki kullanım payı oldukça düşüktür. Teknoloji ve malzeme alanındaki gelişmelerle birlikte fotovoltaik paneller de sürekli geliştirilmekte ve verimlerinde iyileştirmeler yapılmaktadır. Fotovoltaik panel verimine etki eden pek çok faktörden biri de panel yüzey sıcaklığıdır. Bu çalışmada, Denizli ili için bir yıllık çevre sıcaklığı ve güneş ışınımı değerlerine bağlı olarak panel yüzey sıcaklığı hesaplaması yapılmıştır. Panel yüzey sıcaklığının panel çıkış gücüne ve verime etkisi ortaya konmuştur. Panel yüzey sıcaklığının yükselmesiyle verimin doğrusal olarak düştüğü görülmüş ve bu düşüşün her 5 ºC’lik sıcaklık artışında yaklaşık %0,3 değerinde olduğu bulunmuştur.
Consumo voluntario y digestibilidad en ovinos de henos de pasto guinea (Panicum maximum Jacq.)-clitoria (Clitoria ternatea L Dne.) y de pasto rhodes (Chloris gayana Kunth) cv. Callide
Authors: Bismarck Sandoval  , Elide Valencia  , Abner A. Rodríguez  , Paul F. Randel
Published: March 2022

Se realizó un ensayo con el objetivo de comparar el consumo voluntario (CV) y la digestibilidad de materia seca (MS), de proteína bruta (PB), y de fibra detergente neutro (FDN) de heno de pastos guinea-clitoria (HPGC; 33:67%) y heno de pasto rhodes (HPR). Diez carneros criollos adultos con peso promedio de 35 kg se distribuyeron entre los henos evaluados según un diseño experimental de intercambio de tratamientos. El CV fue mayor (P < 0.05) en carneros alimentados con HPGC que con HPR (919 vs. 669 g MS/d). La digestibilidad de la MS (65.19 vs. 55.51%) y de la PB (78.80 vs. 65.19%) también fue mayor (P < 0.05) en HPGC que en HPR; mientras, no se encontró diferencia significativa (P > 0.05) en la digestibilidad de la FDN entre HPGC (58.3%) y HPR (53.9%). La utilización de HPGC mejoró el consumo de MS digerible por 61% en términos relativos con respecto al HPR (599 vs. 371 g/d). Se concluye que el HPGC representa una alternativa promisoria para la alimentación de rumiantes.
HOST INSTAR PREFERENCE OF MIRAX INSULARIS (MUESEBECK) (HYMENOPTERA: BRACONIDAE), A KOINOBIONT PARASITOID OF LEUCOPTERA COFFEELLA GUERIN-MÉNÉVILLE (LEPIDOPTERA: LYONETIIDAE)
Authors: Patricia Navarro-Gutiérrez  , Fernando Gallardo-Covas
Published: March 2022

HOST INSTAR PREFERENCE OF MIRAX INSULARIS (MUESEBECK) (HYMENOPTERA: BRACONIDAE), A KOINOBIONT PARASITOID OF LEUCOPTERA COFFEELLA GUERIN-MÉNÉVILLE (LEPIDOPTERA: LYONETIIDAE)
Use of Remote Sensing and GIS Techniques in Identification of Landslide Vulnerable Zones of Shastri River Basin Along the West Coast of Ratnagiri District, Maharashtra
Authors: Joshi S. B. , Kulkarni D. D.
Published: March 2022

The atmosphere, hydrosphere, and lithosphere are subjected to different processes, leading to natural hazards like weathering, erosion, floods, cyclones, landslides, earthquakes, tectonic movements, etc. Environmental degradation is a serious aspect of the recent past, mainly due to natural and manmade interactions. The pressure for infrastructure development due to rapid urbanization has led to the expansion of construction activities. It has catapulted the frequency of landslides to dramatic proportions in recent decades, especially along western ghats. The West Coast of India (WCI) has attracted the attention of Geo-scientists due to its neo-tectonic setup, continuing seismic activities, sea-level changes, and also due to environmental degradation. It is followed that very limited attempts have been made related to the land sliding along the west coast tract of Maharashtra. The present investigations are emphasized mainly to locate the landslide vulnerable zones of Shastri River Basin (SRB), Ratnagiri district of Maharashtra by using remote sensing data, GIS techniques along field studies. The area lies within a triple junction of Koyana-Kurduwadi Lineament (KKL), West Coast Fault (WCF), and Panvel Flexure (PF). Based on the integration of data from various thematic maps viz. lithology, lineaments, slope, geomorphology, land use-land cover along with inventory map, Landslide Vulnerable Map (LVM) of the SRB has been prepared. It follows that about 29% area of the SRB forms a highly vulnerable zone for land sliding. These zones are mainly confined to steep slopes, wasteland, highly weathered basalts, and deep valleys and in the vicinity of lineaments.