bluuebunny/crossref_metadata_2025 huggingface dataset:
هوية اللاهوت والمجاورة الفلسفية جدل التكامل والتباعد
Authors: زوير أ.م.د. احمد عبدالسادة
Published: November 2023

المستخلص :

يتمحور موضوع البحث في دراسة طبيعة علاقة اللاهوت – بوصف اللاهوت علمًا يتناول المواضيع الإلهية- بعلم الفلسفة التي مثلت ثقافة وافدة من اليونان وسابقة تاريخه في التعامل مع السؤال الأَهم وهو الميتافيزيقا -المفارق للطبيعة (الله)- وكيف تعامل مفكرو المسيحية مع نتائج المعرفة لمن سبقهم في تشكيل انطولوجيا اللاهوت، وصولا إلى تحديد هوية هذا الحقل المهم من حيث اهتمامها بقراءة المجاورة بين الاثنين، والافضاء إلى كشف جدل التكامل والتباعد في صياغة هوية الحقل الجديد -اللاهوت- بعد الاعتماد على معرفة الأدوات الموصلة إلى الغايات المعرفية. وعلى هذا فالبحث يتقصدُ تحديد طبيعة هوية تشكّل اللاهوت وفق دائرة من الجدل الموسوم بالحذر والتماهي عبر مجموعة من نصوص كبار مفكري المسيحية المشكلين لمركزية المنابع في تكون هوية الفكر المسيحي.
شذرات التّيسير النّحويّ في مؤلّفات الدكتور خليل بنيان الحسون
Authors: مكطوف م . د. كريم شيال
Published: November 2023

المستخلص :

يرنو هذا البحث إلى اكتشاف الوقفات التيسيرية التي وقفها الدكتور خليل بنيان الحسون في أثناء نقده للنحويين وهم يستشهدون بالقرآن الكريم والحديث النبوي الشريف، فكان للدكتور خليل آراء يمكن وضعها في خانة التيسير النحوي، لكن هذه الآراء لم تكن في جميع مؤلفاته بل كانت في بعضها، فهي أشبه بالشذرات التي ترصع جزءا من الخاتم ولا تشغل كل أجزائه فتتبعنا تلك الآراء (الشذرات) في بعض مؤلفات الدكتور خليل مثل: (النحويون والقرآن، ولمحات من الآيات، والنحويون والحديث) .
Anglicisms and foreign language borrowings in Russian texts: current situation
Authors: Mavrin V.I. , Smirnova N.L.
Published: November 2023

Процесс языкового заимствования всегда обусловлен экономическими, культурными и другими контактами разных языковых обществ и сам является частью этих контактов. Многообразие культурных и социальных процессов, новые технологии, пришедшие в Россию с Запада, изменили не только жизнь современного россиянина, но и в какой-то степени повлияли на его язык.
Заимствования из английского языка наблюдаются во многих тематических группах русской лексики. В сфере информационных технологий это такие слова, как бод, маркер, картридж, диск CD-ROM, драйвер, софт, хакер, интерфейс, линк, модем, слот, баннер, браузер. В словарь современного делового человека еще в 1990-х вошли такие англицизмы, как бэдж, классификатор, ноутбук (а теперь и его новые разновидности: аудио бук и пауэрбук), органайзер, пейджер, холстер, таймер, бипер, скремблер, интерком, оверхэд, плоттер, сканер, тюнер, тонер, вьюк и другие.
The Effect of Store Atmosphere and Consumer Satisfaction on The Consumer Repurchase Intention of Social Media Cafe J.City Medan
Authors: T Teviana
Published: November 2023

This study aims to determine the Effect of Store Atmosphere and Consumer Satisfaction on Consumer Repurchase Interests of Sosmed Cafe J.City Medan. This research uses quantitative methods with a sampling technique using purposive sampling technique, with a total sample of 100 people who have visited Sosmed Cafe J. City of Medan. Partially Store Atmosphere and Consumer Satisfaction have a positive and significant effect on consumer repurchase intention of Sosmed Cafe J.City Medan. Based on the results of the study, it shows that the Store Atmosphere and Consumer Satisfaction variables simultaneously influence Repurchase Intention. The coefficient of determination test shows a value of 0.522 which means that Store Atmosphere and Consumer Satisfaction have an effect on Repurchase Interest of 52.2% while the rest is influenced by another variable
Pemetaan Minat Belajar Ekonomi pada Mahasiswa Universitas Swasta di Kota Medan Berdasarkan Karakteristik Individu: Suatu Studi Deskriptif
Authors: Muhammad Fitri Rahmadana
Published: November 2023

The aim of this study is to explore the learning interests of accounting students based on individual characteristics. The population of this study is comprised of lecturers and students from the accounting program within the faculty of economics at private universities in Medan. Random sampling was used to select the participants. Data collection techniques included observation, documentary study, interviews, and questionnaires. Qualitative descriptive analysis was used to analyze the data. The results of the study showed that students are interested in learning accounting, although there are still some topics that they find difficult to understand. This is due to the fact that students come from different educational backgrounds and have different genders, and that their learning activities tend to only involve listening to lectures, taking notes, and doing assignments. Therefore, it is necessary to implement varied and innovative learning activities. A learning design using a learning model is needed to help lecturers create an effective, efficient, and engaging learning program, so that the learning outcomes for the introductory accounting course can be achieved.
Gestión y Liderazgo en la universidad
Authors: Oliver Villarroya Javier
Published: November 2023

La transformación en el sistema universitario a partir de la creación del espacio europeo de educación superior ha traído como consecuencia que la gestión universitaria se encuentre inmersa constantemente en un proceso de cambios y estos cambios afectan tanto a los altos gestores académicos como a los procesos de gestión institucionales. A través de mi recorrido profesional voy a describir mi experiencia en la gestión y las acciones que he ido coordinando a lo largo de los años. En todo momento, estas actividades han pretendido tener un efecto positivo sobre la mejora del aprendizaje del estudiante.
Contribución a elevar la calidad en los procesos sustantivos de la Educación superior a través de proyectos I+D. Su aplicación en la Universidad de Holguín, Cuba
Authors: Guilarte Barinaga Elizabeth , Noda Hernández Marcia Esther
Published: November 2023

Este artículo tiene como objetivo exponer la experiencia de la Universidad de Holguín-Cuba, en la integración de un proyecto I+D con los procesos sustantivos Investigación-Formación-Extensión por un período de tres años. Como principales resultados se logró pertinencia del proyecto con el ODS-4 Educación de Calidad y su meta 4.4, así como a nivel nacional también con la plataforma de desarrollo de Cuba hasta 2030. Se elevó la idoneidad del profesorado y estudiantes vinculado al proyecto, como una racionalidad de recursos. Los impactos estuvieron relacionados con indicadores por cada proceso, enfocados en responder a necesidades de la sociedad y se midieron de manera semestral y anual, por el tiempo de duró el proyecto. Se evidenció la importancia de alinear desde el diseño de cualquier propuesta, los indicadores que emplean las Agencias acreditadoras de la Calidad, con el objetivo de garantizar la calidad de lo realizado.
Elementos clave de éxito en la transformación Educativa Nivel Superior
Authors: Maycotte Morales Carlos César
Published: November 2023

La Universidad Americana de Beirut (AUB), en asociación con la Confederación Mundial de Asociaciones de Educación Superior para la Agricultura y las Ciencias de la Vida (GCHERA), La Universidad EARTH y la Fundación WK Kellogg lanzaron un proyecto sobre “Transformación de la Educación Superior”. Este proyecto busca compartir cinco elementos clave del éxito practicadospor la Universidad EARTH y otros con universidades en México y Haití, y todo a través de la red universitaria mundial de GCHERA.La meta del proyecto es abogar por la educación de los futuros lideres con el compromiso de servir la sociedad-líderes capaz de afectar positivamente cambios en su entorno, la promoción de la paz y la comprensión, respetando la diversidad al tiempo que contribuye soluciones para los grandes retos del Siglo XXI. El propósito del proyecto es animar y facilitar procesos de cambiodentro de la universidad, así como para promover un mayor compromiso de la universidad con la comunidad en general para lograr los objetivos gemelos de producir lideres futuros y agentes de cambio, además de fomentar una mayor prosperidad y equidad en la sociedad.
La Enseñanza Matemática en el Contexto Internacional
Authors: Molina Navarro Antonio , Diaz Vega Ma. Eugenia A. , Lagunes Lagunes Elsa G. , Díaz Olaldez Margaríta
Published: November 2023

La enseñanza en la globalización se afirma que ha sufrido un cambio en su forma, debido a los avances de la globalización que implica una mayor interacción entre actores, sociedades y acontecimientos separados dando lugar a una mayor integración entre asuntos locales y externos de diversa índole, y por supuesto el estudio de las matemáticas no pueden quedar exentas y por ello es necesario reconocer y hacer saber a los estudiantes, que en el siglo XXI, deben prepararse para recibir cualquier información y procesarla de manera consciente, de manera tal que requiere una distribución diferente de la inteligencia, no sólo cognitiva sino emocional, lo que implicaría estimular la innovación, la creatividad y la capacitación constante, pero también las parte emotiva del individuo, para poder producir y manejar con éxito dicha emoción, información y conocimiento.
Importancia de la justificación del factor comercial en tasación
Authors: Ramos Vicarte Eduardo Amet , Fernández Mayo Ana Aurora
Published: November 2023

La tasación profesional es un ejercicio interdisciplinario que requiere de conocimientos en áreas como normas legislativas, contabilidad, arquitectura, ingeniería, entre otras, lo que la ha convertido en una ciencia que requiere menos criterio del valuador, aunque de forma indubitable, siempre requerirá del conocimiento y experiencia del tasador. La actividad valuatoria precisa de un correcto análisis del comportamiento del mercado que obliga a conocer primero qué se está ofertando para después seleccionar las muestras que sean más indicativas del objeto de estudio, para poder analizarlas una por una y compararlas a través de una homologación para tratar de igualar las condiciones y características de cada una. Sin embargo, el elemento “criterio” sigue siendo el punto neurálgico para cada valuador, debido a que todos tienen diferentes perspectivas y enfoques del mundo que los rodea, lo que lleva a indicar que lo que para una persona pudiera ser excelente para otra pudiera ser muy buena, para otros simplemente buena, y así sucesivamente. La idea de este estudio es precisamente evitar al máximo los “criterios” y focalizar más a los números que justifican cada factor de tasación para una valuación de calidad.
Los piezoeléctricos: cosechando energía mecánica
Authors: Hernández-Rivera D. , López-Ramírez N.
Published: November 2023

Las energías renovables son fuentes de energía de gran interés debido al menor impacto ecológico que presentan comparadas con las energías fósiles. La cosecha de energía (CdE) es un proceso para obtener energía de fuentes renovables, la cual no ha recibido suficiente atención como los procesos de generación de otras fuentes de energía renovables como la solar, la eólica o la hidráulica; sin embargo, la CdE tiene una gran oportunidad de aplicación para abastecer de energía a dispositivos electrónicos de baja potencia tales como relojes, audífonos, receptores bluetooth, marcapasos, etc. La CdE permite la generación de energía eléctrica a partir de energía ambiental tal como calor, movimiento, vibraciones, y radiación. En este tipo de tecnología, el dispositivo transductor tiene una función primordial ya que permite transformar la energía ambiental en eléctrica. Existen muchos tipos de transductores, sin embargo, los materiales piezoeléctricos destacan, ya que, permiten transformar energía mecánica de diferente naturaleza (vibración, deformación, torsión, etc.) en energía eléctrica. El presente artículo tiene como objetivo informar sobre la cosecha de energía como una alternativa para obtener energías renovables no convencionales y mencionar ciertas aplicaciones donde podemos utilizar a los piezoeléctricos como elementos cosechadores de energía.
Evaluación de la actividad antiepiléptica de los metabolitos secundarios de los extractos cetónicos crudos de Mentha piperita Y Mentha pulegium
Authors: Jiménez-Zuñiga M. I. , López-Duran E. , Gómez-Gómez Y. , Villeda-Guitierrez E. A. , Hurtado-Mariles A. J.
Published: November 2023

La epilepsia se define como un trastorno cerebral caracterizado por la ocurrencia periódica e impredecible de convulsiones, originadas por descargas eléctricas excesivas en un grupo de neuronas en diferentes partes del cerebro; pueden ir desde episodios breves de ausencia o de contracciones musculares que provocan convulsiones prolongadas. Su farmacología emplea anticonvulsivos como carbamazepina, ácido valproico, benzodiacepina y gabapentina; cuyo mecanismo es bloquear los canales de Na+y Cl-; mejorando la función del sistema GABA. El uso de plantas medicinales en México es común, el desarrollo de tratamientos con bioactivos extraídos de estas, reduce efectos secundarios y en ocasiones mejora el tratamiento. El género Menthapresenta efectos relajantes, por lo que se planteó determinar si Mentha piperita y Mentha pulegium poseen actividad anticonvulsiva empleando un modelo in vivo; previamente se realizó un análisis fitoquímico y de actividad antioxidante a partir de los extractos cetónicos crudos que se obtuvieron por sonicación. La prueba in vivo, empleó ratones macho Mus musculus CD-1, 25-35 g de peso (5 grupos, n=5); con el esquema de administración oral: G1 pentilentetrazol PTZ (70 mg/kg), G2 clonazepam (1 mg/kg); G3 carbamazepina (100 mg/kg); G4 extracto M. pulegium (200 m/kg) y G5 extracto M. piperita (200 mg/kg); todos ad libitum de agua y alimento, ciclos de luz/oscuridad invertido (12/12 h, 20-22 °C). M. piperita presentó taninos y M. pulegium presentó flavonoides; su porcentaje de inhibición del radical ABTS fue de 90 y 70% respectivamente, y ambas presentaron diferencia significativa en comparación con el clonazepam y la carbamazepina (ANOVA de una vía, p<0.05); concluyendo que ambas, poseen efecto antioxidante y reducen las convulsiones inducidas con PTZ en ratones.
Tri dekada pas: një përmbledhje tranzicioni për Shqipërinë
Authors: Krasniqi Afrim
Published: November 2023

Ky punim synon të japë një pasqyrë të përmbledhur të problematikavenë sistemin politik dhe përfaqësues të tranzicionit, si dhe të trajtojëdisa prej këtyre aspekteve të debateve mbi tranzicionin në funksion tëtezës se në rastin shqiptar, për shkak të ndikimit të faktorëve tëndryshëm historikë, socialë dhe politikë, rezultatet e tij mund tëkonsiderohen maksimumi i mundshëm që na ofron kjo elitë politikedhe se për të njëjtat arsye, rikthimi i tranzicionit nga fillimi do tëmund të kishte sjellë rezultate të njëjta. Teza e hendekut të madhmidis perceptimeve e pritshmërive mbi bilancin e mundshëm tëtranzicionit dhe kapaciteteve e mundësive reale për ta arritur këtëprogres është plotësuese në këtë drejtim. Shqipëria e nisidemokracinë pa pasur “demokratë”, sistemin shumëpartiak dukepasur të vetmin model referimi sistemin njëpartiak, nuk pati bazëekonomike mikse dhe kushtëzuese ndaj vendimmarrjeve politike, sidhe i dha mandat drejtimi një elite politike të formuar, të rritur dhe tëpromovuar në një sistem të kundërt politik me modelin e shoqërisë sëhapur, për të cilin u angazhuan. Në funksion të tezave kryesorestudimi trajton elementet kryesore të sistemit përfaqësues, përfshintiparet dalluese me modelet e tjera, ndikimet e faktorit ndërkombëtardhe problematikat e përfaqësimit.
Marrëdhëniet tregtare ndërmjet Raguzës dhe shqiptarëve gjatë periudhës osmane nën dritën e disa autorëve
Authors: Malaj Edmond
Published: November 2023

Artikulli synon të jetë si hyrje e shkurtër në studimet rrethmarrëdhënieve ndërmjet shqiptarëve dhe Republikës së Raguzës gjatëperiudhës osmane. Në artikull trajtohen shkrime të botuara ngaautorë të ndryshëm, të cilat kanë një rëndësi të veçantë në lidhje mehistorinë e marrëdhënieve ndërmjet Republikës së Raguzës dheshqiptarëve kryesisht gjatë shek. XVI-XVIII. Artikulli paraqet disarezultate paraprake në lidhje me kërkimin, gjurmimin dhe gjetjenqoftë të dokumenteve, qoftë të punimeve të ndryshme. Këtu poparaqesim disa autorë të rëndësishëm të kësaj teme studimore, pjesamë e madhe e këtyre studiuesve janë sllavë, kryesisht kroatë. Ndëremrat e rëndësishëm të këtyre studiuesve mund të përmendim JosipLuetić, Vuk Vinaver, Bogomil Hrabak, Vinko Ivančević etj. Në artikullsynohet të jepen qasjet kryesore që autorët në fjalë i bëjnë kësaj temenë këta artikuj.
Ideologjia, politika dhe historia: rasit i Kryengritjes së Shqipërisë së Mesme (1914-1915)
Authors: Hoxha Artan R.
Published: November 2023

Ky punim, duke marrë si rast studimi trajtimin e Kryengritjes sëShqipërisë së Mesme të viteve 1914-1915, analizon politizimin ehistorisë gjatë periudhës komuniste dhe përdorimin e saj siinstrument i legjitimit të regjimit stalinist shqiptar. Një hapësirë eposaçme i është kushtuar sidomos ndërhyrjes së Enver Hoxhës mbimënyrën e trajtimit të kësaj kryengritjeje dhe tezave që ai hodhi përinterpretimin e saj. Në këtë artikull, argumentohet se udhëheqësikomunist shqiptar e integroi Kryengritjen e Shqipërisë së Mesmebrenda një skeme historike teleologjike, që kishte për synim tëjustifikonte dhe legjitimonte të tashmen nëpërmjet së shkuarës. SipasE. Hoxhës, lëvizja e armatosur e drejtuar kundër Princ Vidit dhe EsatPashë Toptanit ishte një luftë me karakter klasor, të cilën fshatarësiashqiptare e drejtonte kundër Fuqive të Mëdha europiane dhe klasëssë bejlerëve që u shërbente interesave të huaj në Shqipëri. Përrrjedhim, lufta për emancipimin kombëtar dhe klasor integroheshinnë një emërues të vetëm. Kryengritja e Shqipërisë së Mesme ishërbente Enver Hoxhës për të ndërtuar një traditë revolucionare nëShqipëri, pika kulmore e së cilës ishte qëndresa e drejtuar prejkomunistëve gjatë Luftës së Dytë Botërore. Nevoja për të treguar sethemelimi i PKSh-së dhe ardhja në pushtet e saj nuk ishin aksidentehistorike por rezultat i logjikës së vetë historisë së Shqipërisë, ishtearsyeja pse E. Hoxha i dha Kryengritjes së Shqipërisë së Mesme njërëndësi shumë të madhe dhe të përcaktonte personalisht mënyrën etrajtimit të saj.
PREDIABETES: DIAGNOSIS AND TREATMENT
Authors: Sultanova S.S.
Published: November 2023

The article provides an overview of prediabetes, which precedes diabetes mellitus. It is at this stage that macro- and microvascular complications of diabetes develop. However, it is not always possible to identify this condition, since people with prediabetes have almost no clinical symptoms. At the same time, it is possible to suspect prediabetes. The article presents diagnostic criteria and methods of treatment of early disorders of carbohydrate metabolism. Timely detection of this pathology can prevent the development of diabetes mellitus and its complications.
Membangun Spirit Kewirausahaan Mahasiswa Melalui Layanan Digital Keuangan Syariah
Authors: Mulato Tri , Rahmatia Rahmatia
Published: November 2023

Perkembangan industri keuangan syariah di Indonesia terus mengalami pertumbuhan yang baik. Termasuk kehadiran layanan teknologi yang dapat dimanfaatkan untuk dapat menjangkau layanan kepada masyarakat luas. kehadiran layanan keuangan syariah berupa bank digital syariah yang sudah hadir saat ini, tidak sekedar memberikan layanan keuangan, melainkan ada layanan-layanan yang dapat dijadikan objek untuk berbisnis. Produk dan layanan keuangan syariah dapat menjadi sumber bisnis yang menguntungkan dengan akses yang tidak terbatas waktu dan tempat. Kegiatan ini merupakan kegiatan berupa Transformasi Kreativitas dan Inovasi Kewirausahaan (KIK) yang diselenggarakan oleh Fakultas Ekonomi dan Bisnis Islam Institut Agama Islam Sultan Amai Gorontalo untuk meningkatkan pengetahuan dan skill mahasiswa di bidang kewirausahaa. Pada kegiatan ini melibatkan mentor-mentor dari eksternal berbagai perguruan tinggi di Indonesia. Ada 30 mentor eksternal yang memberikan materi tentang kewirausahaan bagi para peserta, dengan tujuan menambah pengetahuan bisnis, termasuk layanan bisnis digital keuangan syariah. Hasil dari kegiatan pengabdian masyarakat ini berupa peserta memahami bisnis digital khususnya dari lembaga keuangan syariah. Peserta diperkenalkan produk dan layanan dari bank digital syariah, yang dapat ditawarkan untuk dijual untuk memperoleh keuntungan. Serta disampaikan keuntunggan yang dapat diperoleh dengan memanfaatkan bisnis dari layanan bagi digital syariah.
Mindeord
Authors: Sjørslev Inger
Published: November 2023

Mindeord
Liste over anvendte eksterne bedømmere/reviewere på Tidsskriftet Antropologi
Authors: Temaredaktionen
Published: November 2023

Liste over anvendte eksterne bedømmere/reviewere på Tidsskriftet Antropologi
Gamle og kommende numre
Authors: Temaredaktionen
Published: November 2023

Gamle og kommende numre
"Den nordiske model"
Authors: Grünenberg Kristina , Hillersdal Line
Published: November 2023

Der er i de senere år i Danmark sket store forandringer i måderne, hvorpå omsorgog pleje til ældre organiseres i de danske kommuner. Forandringerne ersket for at afbøde, hvad der fra politisk hold vurderes som negative følgevirkningeraf den demografiske udvikling med flere ældre. På denne baggrund erinnovationsmodeller og knowhow, som adresserer disse udfordringer, blevet envare, som både private virksomheder og den nationale sundhedssektor investereri og brander sig på internationalt. I forbindelse med vores feltarbejde har vifulgt udvekslinger af visioner for ældreomsorg mellem Danmark og Sydkorea,mere specifikt mellem strategiske satsninger på digitalisering på Ærø til visionerfor en reorganisering af ældreomsorgen i Busan, Sydkorea. Herudover har vi interviewetmedarbejdere i living labs, politikere og praktikere i ældreomsorgen.Vi argumenterer for, at disse visioner for ældreomsorg udpeger digitale løsningersom svaret på det forventede stigende plejebehov. Visionerne er samtidigindlejret i forestillinger om en „nordisk model“, som kan skaleres på en måde,der både er rettet indad mod aktører i det danske sundhedsvæsen og udad modet internationalt marked. Vi konkluderer, at visionerne, som vi udfolder med begrebetsociotekniske forestillinger, er forbundet med økonomiske styringslogikkerog dagsordener. I den forbindelse peger vi på, at lokale omsorgspraksisserusynliggøres, når visioner for ældreomsorg skaleres, men at de samtidig kan udgøreen ressource for lokale aktører. Artiklen bidrager med viden om, hvordansundhedsinnovation og velfærdsstatslig ældreomsorg udvikles i udvekslingenmellem ekspertise, teknologi og visioner både lokalt og globalt
En mor i Danmark og en mor i Afghanistan
Authors: Møller Nielsen Lærke , Rytter Mikkel
Published: November 2023

En relativt stor del af de asylansøgere, der ankom til Danmark under „migrationenslange sommer“ i 2015, var under 18 år og rejste uden voksne familiemedlemmer.Antallet af uledsagede flygtninge fra Afghanistan var 844 i 2015234og 527 i 2016. Som mindreårige modtager de professionel hjælp, omsorg ogrådgivning i deres asylproces, ligesom de bor på centre med andre børn og unge.Når de bliver tildelt flygtningestatus, får de også tilknyttet en værge, det vil sigeen dansk statsborger, der har meldt sig til at hjælpe den unge med at finde sigtil rette i sin nye hjemkommune. Inspireret af Signe Howells (2006) studier aftransnational adoption i norske familier diskuterer denne artikel den dynamiskeslægtsskabelse, der ofte tager form mellem de unge flygtninge og deres værger.Den turbulente tilblivelse er imidlertid ikke kun et studie af slægts- og familieskabelse,men kan måske også være kim til en mere bæredygtig model forinklusion af flygtninge i Danmark fremover.
The Children of Gregoria
Authors: Skov Erika
Published: November 2023

Anmeldelse af Regnar Kristensen & Claudia Adeath Villamils 'The Children of Gregoria. Dogme Ethnography of a Mexican Family'
Danske resuméer
Authors: Ryborg Jønsson Alexandra Brandt
Published: November 2023

Danske resuméer
Doktorens bord: Det smarte hjem fra teknologiske vision til den levede hverdag
Authors: Kryger Aagaard Line
Published: November 2023

Doktorens bord: Det smarte hjem fra teknologiske vision til den levede hverdag
La rencontre comme mode de production des connaissances : un colloque de cinéma au Festival international Présence autochtone. Entretien avec André Dudemaine
Authors: St-Amand Isabelle
Published: November 2023

Cet entretien revient sur une longue expérience de recherche collaborative dans le domaine émergent du cinéma autochtone : le colloque international Regards autochtones sur les Amériques, tenu depuis 2009 à Montréal et à Kahnawà:ke dans le cadre du Festival international Présence autochtone. L’entretien souligne le rôle du festival dans l’inscription des arts autochtones dans des lieux de légitimation clés de la métropole culturelle qu’est Montréal, puis la discussion se poursuit autour des moments de rencontre qui ont été créés afin de générer des échanges et des savoirs sur le cinéma autochtone à l’échelle locale, continentale et globale. En soi, il vise à dériver des connaissances sur une méthodologie de la recherche collaborative en milieu urbain.
“Inhabited by a Cry”: Representations of Music, Self‑Expression and Survivance in Québécois Indigenous Film
Authors: Gray Claire
Published: November 2023

For Indigenous youth living in Québec, music is a key tool used for self-discovery and identification. As they listen to pre-recorded albums and make their own their music, they discover what cultural markers they possess in terms of national identities, gender boundaries, sexual preference, etc. This article assesses how recent Indigenous Québécois cinema depicts this process of self-discovery in relation to national markers, through the feature film 3 histoires d’Indiens (dir. Robert Morin, 2014) and three short films from the Wapikoni Mobile project. It contemplates how successful these characters are in using music to discover their own identities, the intercultural encounters they have as they go about this process, and crucially, how Indigenous and settler directors represent this cultural journey in differing manners. Through this analysis, this article assesses the important role that music plays in self-discovery, and why the self-representation of Indigenous voices and musicality matters.
Sonia Bonspille Boileau : repenser la présence autochtone dans le milieu
cinématographique
Authors: Gauthier Sarah
Published: November 2023

Réalisé en juillet 2020 dans le but de continuer une discussion entamée durant le
Festival Filministes le 4 mars 2020 sur le film Rustic Oracle (2019), cet entretien
avec la cinéaste québécoise et autochtone Sonia Bonspille Boileau explore les enjeux
entourant la présence autochtone dans l’industrie cinématographique : la représentation, le
financement, la crédibilité, la difficulté de se faire entendre dans le milieu en tant que
femme et les problèmes des Premières Nations qui perdurent aujourd’hui et qui peinent à se
faire reconnaître. En s’attardant sur ses documentaires, son court-métrage We’ll Always
Have Toynbee (2018), son film Le dep (2015), mais principalement sur son plus
récent long métrage Rustic Oracle (2019), Bonspille Boileau aborde l’importance
qu’elle accorde aux détails, la motivation derrière ses choix lorsque vient le temps de
monter une équipe de tournage et de choisir ses acteur·ice·s, ainsi que les changements
qu’elle relève dans le milieu cinématographique.
La Maison Genest-LaRue
Authors: Genest Bernard
Published: November 2023

On l’a connue comme étant la maison Georges-LaRue, puis LaRue, Paul-Gourdeau ou LaRue-Gourdeau. Dans le Répertoire du patrimoine culturel du Québec, on lui a donné le nom du propriétaire de la terre en 1681 : Pierre Mourier. En 1689, la carte de Villeneuve indique la présence d’une habitation, mais en 1709, c’est le nom de Charles Labarre [Genest dit] qui apparaît sur la carte levée par le sieur de Catalogne. S’agit-il de la même maison ? Cela n’a jamais été confirmé. En s’appuyant sur la chaîne des titres et sur les 257 ans d’occupation par les familles Genest et LaRue – deux familles qui ont marqué les annales de Saint-Jean et de l’île d’Orléans – l’auteur conclut que sa désignation devrait refléter sa véritable histoire, en officialisant l’appellation Maison Genest-LaRue.
Enquête sur deux anges adorateurs. L’origine de sculptures en bois doré de l’Hôpital général de Québec
Authors: Payer Claude
Published: November 2023

Traditionnellement déposés en paire sur un autel, de part et d’autre du tabernacle, les anges adorateurs étaient autrefois sculptés par les mêmes artistes qui réalisaient les décors intérieurs des églises et chapelles catholiques. Une paire de ces statuettes, anciennement à l’Hôpital général de Québec, s’inscrit dans une série d’une douzaine d’anges agenouillés de sources diverses, dont l’attribution a radicalement changé il y a quelques années. Les annales du Monastère des Augustines nous révèlent leur provenance et leur destin inattendu.
Repeatability of adaptation in sunflowers: genomic regions harbouring inversions also drive adaptation in species lacking an inversion
Authors: Soudi Shaghayegh , Jahani Mojtaba , Todesco Marco , Owens Gregory L. , Bercovich Natalia , Rieseberg Loren H. , Yeaman Sam
Published: November 2023

Local adaptation commonly involves alleles of large effect, which experience fitness advantages when in positive linkage disequilibrium (LD). Because segregating inversions suppress recombination and facilitate the maintenance of LD between locally adapted loci, they are also commonly found to be associated with adaptive divergence. However, it is unclear what fraction of an adaptive response can be attributed to inversions and alleles of large effect, and whether the loci within an inversion could still drive adaptation in the absence of its recombination-suppressing effect. Here, we use genome-wide association studies to explore patterns of local adaptation in three species of sunflower:
Helianthus annuus
,
H. argophyllus
, and
H. petiolaris
, which each harbour a large number of species-specific inversions. We find evidence of significant genome-wide repeatability in signatures of association to phenotypes and environments, which are particularly enriched within regions of the genome harbouring an inversion in one species. This shows that while inversions may facilitate local adaptation, at least some of the loci can still harbour mutations that make substantial contributions without the benefit of recombination suppression in species lacking a segregating inversion. While a large number of genomic regions show evidence of repeated adaptation, most of the strongest signatures of association still tend to be species-specific, indicating substantial genotypic redundancy for local adaptation in these species.
Structure and evolution of Alanine/Serine Decarboxylases and the engineering of theanine production
Authors: Wang Hao , Zhu Biying , Qiao Siming , Dong Chunxia , Wan Xiaochun , Gong Weimin , Zhang Zhaoliang
Published: November 2023

Ethylamine (EA), the precursor of theanine biosynthesis, is synthesized from alanine decarboxylation by Alanine Decarboxylase (AlaDC) in tea plants. AlaDC evolves from Serine Decarboxylase (SerDC) through neofunctionalization and has lower catalytic activity. However, lacking structure information hinders the understanding of the evolution of substrate specificity and catalytic activity. In this study, we solved the X-ray crystal structures of AlaDC from
Camellia sinensis
(CsAlaDC) and SerDC from
Arabidopsis thaliana
(AtSerDC). Tyr
341
of AtSerDC or the corresponding Tyr
336
of CsAlaDC is essential for their enzymatic activity. Tyr
111
of AtSerDC and the corresponding Phe
106
of CsAlaDC determine their substrate specificity. Both CsAlaDC and AtSerDC have a distinctive zinc finger that contributes to the activity and has not been identified in any other Group II PLP-dependent amino acid decarboxylases. Based on the structure comparison and evolution analysis AlaDC or SerDC led us to perform mutation screen of CsAlaDC. The results indicated that the mutation of L110F or P114A in the CsAlaDC dimerization interface significantly improved the catalytic activity by 110% and 59%, respectively. Combining double mutant CsAlaDC
L110F/P114A
with theanine synthetase increased 672% of theanine production in an
in vitro
system. This study provides the structural basis for the substrate selectivity and catalytic activity of CsAlaDC and AtSerDC and sheds light on a new direction for the efficient industrial synthesis of theanine.
MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production
Authors: O’Brien Conan J O , Ratti Giorgio , Haberman Emma , Sweeney Charles , Gordon Siamon , Domingos Ana I
Published: November 2023

Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin aldosterone system, situated in the adrenal glands, kidneys, and lungs. Here, we reveal that the class A scavenger receptor MARCO, expressed on alveolar macrophages, negatively regulates aldosterone production and suppresses angiotensin converting enzyme (Ace) expression in the lung. Collectively, our findings point to alveolar macrophages as additional players in the renin-angiotensin-aldosterone system and introduce a novel example of interplay between the immune and endocrine systems.
Mimicking the regulatory state of a major facilitator superfamily sugar transporter
Authors: Hariharan Parameswaran , Shi Yuqi , Katsube Satoshi , Willibal Katleen , Burrows Nathan D. , Mitchell Patrick , Bakhtiiari Amirhossein , Stanfield Samantha , Pardon Els , Kaback H. Ronald , Liang Ruibin , Steyaert Jan , Viner Rosa , Guan Lan
Published: November 2023

While many 3D structures of cation-coupled transporters have been determined, the mechanistic details governing the obligatory coupling and functional regulations still remain elusive. The bacterial melibiose transporter (MelB) is a prototype of the Na
+
-coupled major facilitator superfamily transporters. With a conformational nanobody (Nb), we determined an inward-facing Na
+
-bound, low-sugar affinity cryoEM structure. It is the first structure of a major facilitator superfamily (MFS) transporter with experimentally determined cation binding, and also a structure mimicking the physiological regulatory state of MelB under the global regulator EIIA
Glc
of the glucose-specific phosphoenolpyruvate:phosphotransferase system. Collectively with the available outward-facing sugar-bound structures and a large body of functional analysis, we identified that only inner barrier that exists in the outward-facing conformation contributes to the sugar selectivity pocket. When the inner barrier is broken as shown in the inward-facing conformation, the sugar selectivity pocket is also broken, resulting in a decreased sugar-binding affinity by greater than 30-fold, which can facilitate the substrate release and accumulation intracellularly. The inner/outer barrier shifting directly regulates the sugar-binding affinity, with no effect on the cation binding as also suggested by molecular dynamics simulations. Furthermore, the use of the inward-facing conformation-specific Nb in combination with the hydron/deuterium exchange mass spectrometry allowed us to identify dynamic regions linked to the inner barrier-specific charged network and critical for the barrier switching mechanisms. The complementary results provided structural, dynamic, and regulatory insights into the mobile barrier mechanism for cation-coupled symport.
Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis
Authors: Hu Xinyin , Wang Wanyi , Su Xuhan , Peng Haoye , Tan Zuolin , Li Yunqing , Huang Yuhua
Published: November 2023

Objective

To explore the comparative effectiveness of nutritional supplements in improving glycolipid metabolism and endocrine function in patients with polycystic ovary syndrome (PCOS).

Method

Randomized controlled clinical trials on the effects of nutritional supplements in PCOS patients were searched in PubMed, Embase, Cochrane Library, and Web of Science from their establishments to March 15, 2023. Then, literature screening, data extraction, and network meta-analysis were performed. This study was registered at PROSPERO (registration number CRD 42023441257).

Result

Forty-one articles involving 2,362 patients were included in this study. The network meta-analysis showed that carnitine, inositol, and probiotics reduced body weight and body mass index (BMI) compared to placebo, and carnitine outperformed the other supplements (SUCRAs: 96.04%, 97.73%, respectively). Omega-3 lowered fasting blood glucose (FBG) (SUCRAs: 93.53%), and chromium reduced fasting insulin (FINS) (SUCRAs: 72.90%); both were superior to placebo in improving insulin resistance index (HOMA-IR), and chromium was more effective than Omega-3 (SUCRAs: 79.99%). Selenium was potent in raising the quantitative insulin sensitivity index (QUICKI) (SUCRAs: 87.92%). Coenzyme Q10 was the most effective in reducing triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (SUCRAs: 87.71%, 98.78%, and 98.70%, respectively). Chromium and probiotics decreased TG levels, while chromium and vitamin D decreased TC levels. No significant differences were observed in high-density lipoprotein cholesterol (HDL-C), total testosterone (TT), sex-hormone binding globulin (SHBG), and C-reactive protein (CRP) between nutritional supplements and placebo.

Conclusion

Carnitine was relatively effective in reducing body mass, while chromium, Omega-3, and selenium were beneficial for improving glucose metabolism. Meanwhile, coenzyme Q10 was more efficacious for improving lipid metabolism. However, publication bias may exist, and more high-quality clinical randomized controlled trials are needed.
A pyroptosis gene-based prognostic model for predicting survival in low-grade glioma
Authors: Wang Hua , Yan Lin , Liu Lixiao , Lu Xianghe , Chen Yingyu , Zhang Qian , Chen Mengyu , Cai Lin , Dai Zhang’an
Published: November 2023

Background

Pyroptosis, a lytic form of programmed cell death initiated by inflammasomes, has been reported to be closely associated with tumor proliferation, invasion and metastasis. However, the roles of pyroptosis genes (PGs) in low-grade glioma (LGG) remain unclear.

Methods

We obtained information for 1,681 samples, including the mRNA expression profiles of LGGs and normal brain tissues and the relevant corresponding clinical information from two public datasets, TCGA and GTEx, and identified 45 differentially expressed pyroptosis genes (DEPGs). Among these DEPGs, nine hub pyroptosis genes (HPGs) were identified and used to construct a genetic risk scoring model. A total of 476 patients, selected as the training group, were divided into low-risk and high-risk groups according to the risk score. The area under the curve (AUC) values of the receiver operating characteristic (ROC) curves verified the accuracy of the model, and a nomogram combining the risk score and clinicopathological characteristics was used to predict the overall survival (OS) of LGG patients. In addition, a cohort from the Gene Expression Omnibus (GEO) database was selected as a validation group to verify the stability of the model. qRT-PCR was used to analyze the gene expression levels of nine HPGs in paracancerous and tumor tissues from 10 LGG patients.

Results

Survival analysis showed that, compared with patients in the low-risk group, patients in the high-risk group had a poorer prognosis. A risk score model combining PG expression levels with clinical features was considered an independent risk factor. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicated that immune-related genes were enriched among the DEPGs and that immune activity was increased in the high-risk group.

Conclusion

In summary, we successfully constructed a model to predict the prognosis of LGG patients, which will help to promote individualized treatment and provide potential new targets for immunotherapy.
Pharmacological Treatment of Acute Unilateral Vestibulopathy: A Review
Authors: Sousa Francisco Alves de , Alves Clara Serdoura , Pinto Ana Nóbrega , Meireles Luís , Rego Ângela Reis
Published: November 2023

There have been few investigations on the epidemiology, etiology, and medical management of acute unilateral vestibulopathy (AUV). Short-term pharmaceutical resolutions include vestibular symptomatic suppressants, anti-emetics, and some cause-based therapies. Anticholinergics, phenothiazines, antihistamines, antidopaminergics, benzodiazepines, and calcium channel antagonists are examples of vestibular suppressants. Some of these medications may show their effects through multiple mechanisms. In contrast, N-acetyl-L-leucine, Ginkgo biloba, and betahistine improve central vestibular compensation. Currently, AUV pathophysiology is poorly understood. Diverse hypotheses have previously been identified which have brought about some causal treatments presently used. According to some publications, acute administration of anti-inflammatory medications may have a deleterious impact on both post-lesional functional recovery and endogenous adaptive plasticity processes. Thus, some authors do not recommend the use of corticosteroids in AUV. Antivirals are even more contentious in the context of AUV treatment. Although vascular theories have been presented, no verified investigations employing anti-clotting or vasodilator medications have been conducted. There are no standardized treatment protocols for AUV to date, and the pharmacological treatment of AUV is still questionable. This review addresses the most current developments and controversies in AUV medical treatment.
Adaptation and Validation of the Perceptual Performance Test in Malayalam
Authors: Dhrruvakumar Shubhaganga , Kooknoor Vishal , ShajiKumar Saratlal , Veerabhadrappa Rakesh C.
Published: November 2023

Background and Objectives: The discrepancies between the objective and subjective measurements used to select and fit hearing aids indirectly impact the perceived benefit and perception in the presence of noise. This study aimed to bridge the gap between objective and subjective measurements in hearing aid fitting by adapting and validating the “Perceptual Performance Test (PPT)” in Malayalam.Subjects and Methods: Standardized Malayalam-language sentences were used to adapt PPT and administer it to 65 native Malayalam speakers (30 normal and 35 hearing impaired). Performance and perception speech recognition thresholds in noise (SRTN) and Performance-Perceptual Discrepancy (PPDIS) were evaluated at various noise levels along with Hearing Handicap Inventory for the Elderly (HHIE) or Adults (HHIA).Results: Both perceptual and performance SRTNs were better among normal-hearing individuals than in the hearing-impaired group. Moreover, the participants with hearing impairment were found to have a significant effect of noise level on both the measures, which was otherwise not seen among normal-hearing individuals. The normative criteria for PPDIS were established to categorize the individuals as under-, over-, or accurate estimators. The performance and perception outcomes varied significantly between groups (normal hearing and hearing impaired) and across noise levels. Furthermore, there was a positive correlation between perceptual and performance SRTNs with emotional and social subscales and total HHIE/A scores. Additionally, a negative association was noted between PPDIS values and HHIE/A scores.Conclusions: The adapted test is a valid and reliable tool for evaluating the benefit of hearing aids. PPDIS can provide crucial information to audiologists regarding an individual’s judgement about their hearing ability, with an explanation for the discrepancy between objective and subjective reports of hearing impairments.
Spielberg’s Secret
Authors: Menzin Eleanor R.
Published: November 2023

This essay describes how a podcast inspired a physician’s new approach to complimenting patients and colleagues and the benefits gained.
I Am Worried I Have Sciatica—What Do I Need to Know?
Authors: Zhang Grace Y. , Incze Michael A.
Published: November 2023

This JAMA Internal Medicine Patient Page reviews sciatica, its symptoms, and treatment options for those who have it.
Widening Gender Gap in Life Expectancy in the US, 2010-2021
Authors: Yan Brandon W. , Arias Elizabeth , Geller Alan C. , Miller Donald R. , Kochanek Kenneth D. , Koh Howard K.
Published: November 2023

This cross-sectional study systematically examines the contributions of COVID-19 and other underlying causes of death to the widened gender life expectancy gap from 2010 to 2021.
Police Violence in Health Care Settings in US Media Coverage
Authors: Saadi Altaf , Ray Victor E.
Published: November 2023

Importance

Hospitals do not collect or share data tracking their policing and security activities despite their reliance on police and security personnel, including armed officers. Thus, little is known about how hospital security is associated with patient and staff safety.

Objective

To examine the harms exerted by health care–affiliated police and security personnel.

Design, Setting, and Participants

For this qualitative study, data were collected using a systematic Media Cloud search for US news media coverage from January 2011 to May 2022. A total of 18 987 articles on policing and hospitals were screened and a content and thematic analysis of articles that met the search criteria was conducted, which involved incidents that revealed harm to patients, patients’ families, and staff. Data were analyzed from October 2022 to April 2023.

Main Outcomes and Measures

Incident year, incident location (hospital name, city, state), survivor and victim characteristics (race and ethnicity, presence of mental illness), and a narrative description of the incident focusing on outcomes of harm exerted by police and security personnel in the health care setting.

Results

A total of 48 unique stories across 25 US states were included. The median (range) year published was 2017 (2009-2022). Harms reported to have been perpetuated by health care–affiliated police and security personnel were identified within 5 domains from 48 unique incidents: (1) patients shot by police or security personnel (17 patients); (2) patients subject to excessive use of force (17 patients); (3) patients arrested (7 patients); (4) patients subject to sexual assault (2 patients); and (5) hospital personnel or those considered collateral damage shot, injured, or arrested (5 individuals). Most survivors and victims were Black, although the race and/or ethnicity of involved individuals was not routinely reported across the news stories. Mental illness was the most documented medical condition among patients injured or killed by health care–affiliated police and security personnel.

Conclusions and Relevance

This qualitative study of US news media found that police and security personnel in hospitals were reported to have perpetuated harm via excessive force, sexual assaults, injuring patients and health care workers, and fatal shootings. Compounded by a lack of transparency and accountability mechanisms, this may represent an underrecognized manifestation of structural racism at the organizational level. Policy suggestions include introducing accountability measures, deescalation techniques, and removing arms from hospital security personnel to reduce harm and fulfill health care’s healing mission.