bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning Models for Image-Based Diagnosis and Prognosis of COVID-19: Systematic Review
Authors: Montazeri Mahdieh , ZahediNasab Roxana , Farahani Ali , Mohseni Hadis , Ghasemian Fahimeh
Published: March 2021

Background

Accurate and timely diagnosis and effective prognosis of the disease is important to provide the best possible care for patients with COVID-19 and reduce the burden on the health care system. Machine learning methods can play a vital role in the diagnosis of COVID-19 by processing chest x-ray images.

Objective

The aim of this study is to summarize information on the use of intelligent models for the diagnosis and prognosis of COVID-19 to help with early and timely diagnosis, minimize prolonged diagnosis, and improve overall health care.

Methods

A systematic search of databases, including PubMed, Web of Science, IEEE, ProQuest, Scopus, bioRxiv, and medRxiv, was performed for COVID-19–related studies published up to May 24, 2020. This study was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. All original research articles describing the application of image processing for the prediction and diagnosis of COVID-19 were considered in the analysis. Two reviewers independently assessed the published papers to determine eligibility for inclusion in the analysis. Risk of bias was evaluated using the Prediction Model Risk of Bias Assessment Tool.

Results

Of the 629 articles retrieved, 44 articles were included. We identified 4 prognosis models for calculating prediction of disease severity and estimation of confinement time for individual patients, and 40 diagnostic models for detecting COVID-19 from normal or other pneumonias. Most included studies used deep learning methods based on convolutional neural networks, which have been widely used as a classification algorithm. The most frequently reported predictors of prognosis in patients with COVID-19 included age, computed tomography data, gender, comorbidities, symptoms, and laboratory findings. Deep convolutional neural networks obtained better results compared with non–neural network–based methods. Moreover, all of the models were found to be at high risk of bias due to the lack of information about the study population, intended groups, and inappropriate reporting.

Conclusions

Machine learning models used for the diagnosis and prognosis of COVID-19 showed excellent discriminative performance. However, these models were at high risk of bias, because of various reasons such as inadequate information about study participants, randomization process, and the lack of external validation, which may have resulted in the optimistic reporting of these models. Hence, our findings do not recommend any of the current models to be used in practice for the diagnosis and prognosis of COVID-19.
A Social Media–Promoted Educational Community of Joint Replacement Patients Using the WeChat App: Survey Study (Preprint)
Authors: Zhang Xianzuo , Chen Xiaoxuan , Kourkoumelis Nikolaos , Gao Ran , Li Guoyuan , Zhu Chen
Published: March 2021

BACKGROUND

Much effort has been made to optimize the results of total hip arthroplasty and total knee arthroplasty. With the rapid growth of social media use, mobile apps, such as WeChat, have been considered for improving outcomes and patient satisfaction after total hip arthroplasty and total knee arthroplasty.

OBJECTIVE

We aimed to evaluate the effectiveness of a WeChat-based community as an intervention for overall patient satisfaction.

METHODS

The study was conducted among discharged in-hospital patients who received hip or knee procedures in the First Affiliated Hospital of the University of Science and Technology of China from April 2019 to January 2020. An educational online social community was constructed with the WeChat app. Participants willing to join the community were enrolled in a WeChat group and received 3 months of intervention and follow-up. Those who were not willing to use the account were included in a control group and received routine publicity via telephone, mail, and brochures. The Danish Health and Medicine Authority patient satisfaction questionnaire was used to score perioperative patient education and overall satisfaction. The contents in the group chat were analyzed using natural language processing tools.

RESULTS

A total of 3428 patients were enrolled in the study, including 2292 in the WeChat group and 1236 in the control group. Participants in the WeChat group had higher overall satisfaction scores than those in the control group (mean 8.48, SD 1.12 vs mean 6.66, SD 1.80, P<.001). The difference between the two groups was significant for primary surgery based on subgroup stratification. To control confounding factors and explore the effects of WeChat participation as a mediating variable between perioperative patient education and overall satisfaction, hierarchical regression was utilized. An interpatient interaction model was found in the community group chat, and it contributed to overall satisfaction. Patients in the group with more interpatient interactions were more likely to have better overall satisfaction.

CONCLUSIONS

The social media–promoted educational community using WeChat was effective among joint replacement patients. Provision of more perioperative education is associated with more active patient participation in the community and therefore more patient satisfaction in terms of the overall joint procedure. Community group chat could facilitate interactions among patients and contribute to overall satisfaction.
Predicting Outcomes in Patients Undergoing Pancreatectomy Using Wearable Technology and Machine Learning: Prospective Cohort Study (Preprint)
Authors: Cos Heidy , Li Dingwen , Williams Gregory , Chininis Jeffrey , Dai Ruixuan , Zhang Jingwen , Srivastava Rohit , Raper Lacey , Sanford Dominic , Hawkins William , Lu Chenyang , Hammill Chet W
Published: March 2021

BACKGROUND

Pancreatic cancer is the third leading cause of cancer-related deaths, and although pancreatectomy is currently the only curative treatment, it is associated with significant morbidity.

OBJECTIVE

The objective of this study was to evaluate the utility of wearable telemonitoring technologies to predict treatment outcomes using patient activity metrics and machine learning.

METHODS

In this prospective, single-center, single-cohort study, patients scheduled for pancreatectomy were provided with a wearable telemonitoring device to be worn prior to surgery. Patient clinical data were collected and all patients were evaluated using the American College of Surgeons National Surgical Quality Improvement Program surgical risk calculator (ACS-NSQIP SRC). Machine learning models were developed to predict whether patients would have a textbook outcome and compared with the ACS-NSQIP SRC using area under the receiver operating characteristic (AUROC) curves.

RESULTS

Between February 2019 and February 2020, 48 patients completed the study. Patient activity metrics were collected over an average of 27.8 days before surgery. Patients took an average of 4162.1 (SD 4052.6) steps per day and had an average heart rate of 75.6 (SD 14.8) beats per minute. Twenty-eight (58%) patients had a textbook outcome after pancreatectomy. The group of 20 (42%) patients who did not have a textbook outcome included 14 patients with severe complications and 11 patients requiring readmission. The ACS-NSQIP SRC had an AUROC curve of 0.6333 to predict failure to achieve a textbook outcome, while our model combining patient clinical characteristics and patient activity data achieved the highest performance with an AUROC curve of 0.7875.

CONCLUSIONS

Machine learning models outperformed ACS-NSQIP SRC estimates in predicting textbook outcomes after pancreatectomy. The highest performance was observed when machine learning models incorporated patient clinical characteristics and activity metrics.
eHealth Program to Reduce Hospitalizations Due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Retrospective Study (Preprint)
Authors: van Buul Amanda R , Derksen Caroline , Hoedemaker Ouke , van Dijk Oscar , Chavannes Niels H , Kasteleyn Marise J
Published: March 2021

BACKGROUND

Hospitalization for acute exacerbation of chronic obstructive pulmonary disease (COPD) is associated with poor prognosis. eHealth interventions might improve outcomes and decrease costs.

OBJECTIVE

This study aimed to evaluate the effect of an eHealth program on COPD hospitalizations and exacerbations.

METHODS

This was a real-world study conducted from April 2018 to December 2019 in the Bravis Hospital, the Netherlands. An eHealth program (EmmaCOPD) was offered to COPD patients at risk of exacerbations. EmmaCOPD consisted of an app that used questionnaires (to monitor symptoms) and a step counter (to monitor the number of steps) to detect exacerbations. Patients and their buddies received feedback when their symptoms worsened or the number of steps declined. Generalized estimating equations were used to compare the number of days admitted to the hospital and the total number of exacerbations 12 months before and (max) 18 months after the start of EmmaCOPD. We additionally adjusted for the potential confounders of age, sex, COPD severity, and inhaled corticosteroid use.

RESULTS

The 29 included patients had a mean forced expiratory volume in 1 second of 45.5 (SD 17.7) %predicted. In the year before the intervention, the median total number of exacerbations was 2.0 (IQR 2.0-3.0). The median number of hospitalized days was 8.0 days (IQR 6.0-16.5 days). Afterwards, there was a median 1.0 (IQR 0.0-2.0) exacerbation and 2.0 days (IQR 0.0-4.0 days) of hospitalization. After initiation of EmmaCOPD, both the number of hospitalized days and total number of exacerbations decreased significantly (incidence rate ratio 0.209, 95% CI 0.116-0.382; incidence rate ratio 0.310, 95% CI 0.219-0.438). Adjustment for confounders did not affect the results.

CONCLUSIONS

The eHealth program seems to reduce the number of total exacerbations and number of days of hospitalization due to exacerbations of COPD.
The Numerous Benefits of Social Media for Medicine. Comment on “Documenting Social Media Engagement as Scholarship: A New Model for Assessing Academic Accomplishment for the Health Professions” (Preprint)
Authors: Gambril John Alan , Boyd Carter J , Egbaria Jamal
Published: March 2021

UNSTRUCTURED

n/a
Greek Revolution and Art. The protagonists on Marble. Illustrative and Typological Specimens
Authors: Tsichla Markella-Elpida
Published: March 2021

The Greek Revolution of 1821 was one of the most important issues in Europe of the early 19th century on a political and military level. The outbreak of the Greek Revolution was not supported by the Great Powers of the time, since as a liberation struggle it violated the terms of the Holy Alliance (1815), however it managed to prevail thanks to the support of the people of Europe as they regarded this an effort of a small nation to claim its freedom and oppose to slavery and authoritarianism. After all, we are in the time of Romanticism and this kind of struggle enjoyed the support of intellectuals, collectives, and different groups of citizens. Philhellenism was on the rise, and painters like Delacroix made a huge impact with works that made a strong impression on Europe. After the success of the Revolution, many foreign artists came to Greece, some on their own initiative as travelers and others carrying out their King’s orders. Some of them were painters (both amateur and professional) that painted live portraits of the leading figures of the Revolution, leaving behind a remarkable oeuvre when seen from a historical, factual, and artistic point of view. And since at that point in Greece there could be no room for domestic artistic creation, the work of these artists is considered particularly important in terms of portraiture, history, facts, and artistic value. The most important out of the painters that were in Greece at that critical time are the Bavarians Karl Krazeisen and Peter von Hess, who painted portraits of Greek fighters and these portraits have since become the blueprints that other artists, painters, and sculptors based their work on resulting in the perpetuation of the historical memory.It is worth mentioning that in the 200 years of independence these works remain of enduring value when paying tribute and respect to the first martyrs of the Greek Struggle.
Routledge Handbook on Development Ethics
Authors: Paul Norvy
Published: March 2021

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A RARE CASE REPORT ON MYXOEDEMA COMA
Authors: B SHANTHI , CHANDRIKA A MARY
Published: March 2021

Myxoedema coma is a sporadic life-threatening complication of severe hypothyroidism with high mortality. Altered mental status and hypothermia are the main symptoms of myxoedema coma. Apart from that, hypoxia, bradycardia, hypotension, anemia, and hyponatremia would be present. Few patients present comatose with severe myxoedema. Presenting coma may mislead the diagnosis of this condition. A female patient presented with fever, breathlessness, and disorientation was admitted. First diagnosed to have electrolyte imbalance and treatment was started accordingly. The patient did not show much of an improvement, and it took a day to identify the presence of severe hypothyroidism. Treating hypothyroidism resulted in an advance in the patient condition. Patients’ previous history of hypothyroidism was not informed during admission. It is always tough to diagnose myxoedema coma when the patients’ previous history of hypothyroidism is unknown. Hence, it is still essential to have hypothyroidism in mind while treating patients with comatose. This case has been reported to alert physicians in diagnosing myxoedema coma patients and to proceed with the treatment at the earliest.
SODIUM-GLUCOSE LINKED COTRANSPORTER 2 INHIBITOR: A NEW HORIZON IN THE TREATMENT OF TYPE-2 DIABETES
Authors: BISHT REKHA
Published: March 2021

Hyperglycemia is a key therapeutic focus in the management of patients with type 2 diabetes (T2D) mellitus. The various therapeutic classes of antidiabetic drugs presently existing in the market are not sufficiently effective in maintaining long-term glycemic control in most of the diabetic patients, even when used in combination. The undesirable adverse effects of these drugs, such as hypoglycemia, weight gain, and hepatic and renal toxicity, have escalated the demand for the discovery of new and safer antidiabetic drugs. The progressive nature of T2D requires practitioners to periodically evaluate patients and intensify glucose-lowering treatment once glycemic targets are not attained. Sodium-glucose cotransporter 2 inhibitors (SGLT2-is) are the new class of antidiabetic medications that are approved (2013) by the Food and Drug Administration recently for treating diabetes. These inhibitors block the SGLT2 protein involved in glucose reabsorption from the proximal renal tubule resulting in escalated glucose excretion and lower blood glucose levels. These inhibitors exhibit favorable effects beyond glucose control, such as consistent body weight, blood pressure, and serum uric acid reductions. This review highlighted the brief updates of SGLT2-i, their benefits, and adverse effects.
BREAST CANCER ACTIVITY OF ISOLATED COMPOUND FROM TINOSPORA CORDIFOLIA AERIAL
Authors: A SREEDEVI , RETNA A MALAR
Published: March 2021

Objectives: The present study undertaken to explore antioxidant and the cell line study of isolated compound from ethanol extract from Tinospora cordifolia belongs to the family Menispermaceae.

Methods: The air dried powdered sample of aerial parts of T. cordifolia was extracted in a Soxhlet using five different solvents. Most active ethanol extracts were purified using silica gel column chromatography. Characterized the structure of the isolated compound using Fourier transform infrared spectrum, 1H nuclear magnetic resonance, and liquid chromatography–mass spectrometry studies. Antioxidant and anticancer activity of isolated compound was determined using 2,2-diphenyl-1-picrylhydrazyl and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

Results: Magnoflorine was isolated from most active ethanol extract from aerial parts of T. cordifolia which shows maximum antioxidant activity 64% at the tested concentration 500 μg/ml. The percentage of cell viability varied from 53.3% at the minimum tested concentration 3.12 μg/ml to 1.9% at the maximum tested concentration 100 μg/ml.

Conclusion: The isolated characterized compounds would be useful to prepare plant-based pharmaceutical preparation to treat various diseases linked with human diseases.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENTIAL OF PTEROCARPUS SANTALINUS L.F. PLANT PARTS
Authors: B BHARATHI , NBL PRASAD
Published: March 2021

Objective: Oxidation is a normal process in many biological metabolisms in living beings, but in this technology era radiation, pollution, irregular life style, and unhealthy diet leads to excessive oxidation resulting in imbalance between antioxidants and free radicals in body called oxidative stress, which may result in cardiac problems, diabetes, and carcinogenic diseases. Therefore, exploration of natural antioxidants in flora and fauna is becoming important. In this motive a phytochemical study was taken up on various parts of Pterocarpus santalinus L.f. plant belonging to Leguminosae family to check the presence of antioxidant activity (AA).

Methods: The leaves, flowers, fruits, and roots of this plant were extracted with six different organic solvents from polar to non-polar. To estimate the AA of these extracts, four types of antioxidant tests were done on them, namely, α, α – Diphenyl – β – Picryl - Hydrazyl free radical scavenging activity (DPPH RSA) assay, relative reducing power (RRP) assay, Ferric thiocyanate (FTC) assay, and β - carotene bleaching assay with Butylated Hydroxy Toluene (BHT) as synthetic standard.

Results: In extraction, Me extracts showed highest yields. Qualitative phytochemical screening has revealed many bioactive components in the Me and Et extracts of plant parts majorly. In DPPH RSA assay, Me extracts of leaves showed RSA activity almost equal to reference standard. In RRP assay, Me floral extracts showed AA higher than standard. FTC and β – Carotene assays showed that Me sample extracts possess good AA than BHT. In FTC assay, lower absorption values specify high AA, whereas in β – Carotene assay, high absorption values indicate high AA of the sample extracts.

Conclusion: Among six solvents methanol showed highest extraction efficiency and also revealed highest number of phytochemicals in its extracts. These four AA assays revealed that the methanol extracts of all plant parts, that is., leaves, roots, fruits, and flowers possess better AA compared other solvent extracts.
STUDY OF ACCESSORY SUPRAORBITAL FORAMEN IN NORTH INDIAN HUMAN SKULL
Authors: P NIRALA KAMTA , GUPTA AMRITA , SHUKLA SAGUN , GUPTA SUBHASH
Published: March 2021

Objective: This research was aimed at telling the anatomical characteristics of the accessory supraorbital foramen (ASOF) in relation to the main supraorbital foramen (SOF), which is necessary in clinical situations that require regional surgical procedures.

Methods: A total dedicated to the presence and location of 72 dry Indian adults of unknown age and sex were investigated. In each skull, the ASOF location was measured on both sides with a Vernier caliper metal case, with the SOF as the reference point. The total number of accessory foramen was also noted.

Results: Accessory infraorbital foramens (IOFs) were seen only in 4.16% in our study and all seen were single in number. Half of those accessory foramen were present on medial and rest half were present on superomedial position as compared to the main IOF. Half among present accessory foramens were located at a distance of <2 mm and half were located at a distance of more than 2 mm. The mean location of accessory IOF was at 7.07 mm from main IOF.

Conclusion: Knowledge of the anatomical characteristics of ASOF can have major effects on surgical and local anesthetic preparation blockage of the super orbital nerves. Additional guidance for surgeons may be provided with information on the foramens obtained from this study. The surgeons should note this during the nerve block as damage to either branch will lead to sensory impairment and incomplete blocking of the nerve.
A REVIEW ON AGENTS FOR THE TREATMENT OF LEPROSY INFECTION
Authors: HABIBALLA AHMED MUHANAD MOHAMED , ANURADHA  , WADHWA PANKAJ
Published: March 2021

Leprosy is an ancient disease which is caused due to bacterial infection while curable but endures to be a substantial health problem in numerous parts across the world. It is an extremely contagious disease that is caused by any of 3 strains of bacteria such as Mycobacterium tuberculosis; Nontuberculous Mycobacterium; and Mycobacterium leprae. In several regions of Brazil, leprosy is a health issue which is still an endemic. Mainly skin, peripheral nerves, eyes, and mucosa of the upper respiratory tract are affected due to this chronic infection. As per the data shared by WHO across 159 countries globally, there were around 208,619 new leprosy cases reported. The global prevalence of leprosy is overcome with the aid of multidrug therapy which remains to be the chiefly targeted for treatment. The multidrug therapy gets attention as they show tremendous potential in fighting this disease. This review briefs about the different drugs and strategies which are used in treatment and superintendence of leprosy.
ASSESSMENT OF KNOWLEDGE, ATTITUDE, AND PRACTICE ABOUT PACKAGE INSERTS AMONG MEDICAL UNDERGRADUATE STUDENTS: A CROSS-SECTIONAL QUESTIONNAIRE-BASED STUDY
Authors: PRABHA MP SNEHA , S PRABHAKARAN SONISH
Published: March 2021

Objective: The objective of our study was to assess knowledge, attitude, and practice regarding package inserts (PIs) among medical undergraduates of a Government Medical College in Kerala, India

Methods: A cross-sectional, questionnaire-based study was carried out on 100 medical students. It was conducted with the consent of all participants and after the approval of Institutional Review Board and Ethics Committee. Pre-validated 15 items questionnaire was used to elicit responses about knowledge, attitude, and practice with a scoring scheme of +1 for “yes”/positive response and 0 for “no/I don’t know”/negative response. Data analyzed using “SPSS” and responses were expressed as mean scores and percentages.

Results: Statistical analysis (response rate 98%) revealed that 88.2% have seen PIs but only 18.4% had the knowledge of drug acts governing the information to be provided on PIs in India. About 78.6% agreed PIs are necessary add-on to drug information. About 62.2% opined that PIs must be in regional language along with English. About 100% agreed that written information in PIs is difficult to read and understand. About 66.3% feel that doctors must instruct patients to read PIs thoroughly. About 71.4% have referred PIs as a source of knowledge for Indication/Contraindication/ Adverse Effects/Drug interaction. About 95.9% would like to refer PIs in future while prescribing as physician.

Conclusion: We conclude that participants have positive attitude toward PIs but have less knowledge as compared with developed countries. Results suggest the need for escalating knowledge and awareness among medical students about PIs which, in turn, help to minimize medication errors.
FORMULATION DEVELOPMENT AND CHARACTERIZATION OF GELUCIRE BEADS OF ANTIHYPERTENSIVE DRUG FOR FLOATING DRUG DELIVERY SYSTEM USING 32 FACTORIAL DESIGNS
Authors: RANKA KHUSHBOO , S RATHORE KAMAL
Published: March 2021

Objective: The aim of this study was to design and to optimize lipid based beads for multiunit floating drug delivery of ramipril.

Methods: The beads prepared by melt-solidification method. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of Gelucire (X1) and Tween 20 (X2) as independent variable and the percentage drug release in 1 (Y1), 6 (Y2), and 12 h (Y3) as dependent variable. Gelucire 43/01 has chosen for release retardant and Tween 20 for solubility enhancement and drug loading agent.

Results: The results of multiple linear regression analysis indicated that for obtain a floating drug delivery, the optimum concentrations of both the lipid and drug loading agent should be used. The factorial models were used to prepare optimized floating beads and optimized formulations showed controlled release profiles for the extended period of more than 12 h.

Conclusion: From the study, it was concluded that beads of Gelucire for sparingly water-soluble drug ramipril can provide controlled release for extended period.
The role of bone anabolic drugs in the management of periodontitis: a scoping review
Authors:   Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy, Cecoro G , Paoletta M , Annunziata M , Laino L , Nastri L , Gimigliano F , Liguori S , Toro G , Moretti A , Guida L , Iolascon G
Published: March 2021

The aim of this scoping review was to summarise current knowledge about the effects of bone anabolic drugs on periodontitis, in order to identify new therapeutic strategies for preventing disease progression and reducing tooth loss. A technical expert panel (TEP) was established of 11 medical specialists, including periodontists and bone specialists that followed the PRISMA-ScR model to perform the scoping review and considered for eligibility both pre-clinical and clinical studies published in the English language up to September 2020. 716 items were initially found. After duplicate removal and screening of articles for eligibility criteria, 25 articles published between 2001 and 2019 were selected. Only studies concerning teriparatide, strontium ranelate, sclerostin antibodies and DKK1 antibodies met the eligibility criteria. In particular, only for teriparatide were there both clinical studies and experimental studies available, while for other bone anabolic drugs only animal studies were found. Available evidence about the use of bone anabolic drugs in periodontology demonstrates beneficial effects of these agents on biological pathways and histological parameters involved in periodontal tissue regeneration that suggest relevant clinical implications for the management of periodontitis.
A legitimidade do bloqueio múltiplo de valores - penhora on-line
Authors: De Souza Melo Thiago
Published: March 2021

Nesse estudo, pretende-se analisar a legitimidade do bloqueio múltiplo de ativos financeiros executados

frente aos dispositivos do Código de Processo Civil de 2015. Mais especificamente, o objetivo central é

analisar o artigo 854, caput e § 1º, do Código, que estabelece determinada conduta ao magistrado quando

da emissão de ordens de indisponibilidade de dinheiro. Para tanto, faz-se uma explanação sobre o próprio

sistema da penhora on-line e, em seguida, se discorre sobre os princípios processuais que podem ser

aplicados no contexto da multiplicidade de bloqueios. Ao final, com o auxílio de renomados doutrinadores,

chega-se à conclusão de que o bloqueio múltiplo de dinheiro do executado, além de legítimo, é o

procedimento ou método que proporciona o mais justo equilíbrio no cenário da penhora on-line.
Responsabilidade civil nos contratos de transporte aéreo internacional: da uniformização à harmonização das legislações aplicáveis
Authors: Targa Maria Luiza Baillo
Published: March 2021

No presente artigo, por meio da revisão bibliográfica e da análise de casos concretos, objetiva-se
investigar, inicialmente, o desenvolvimento da regulamentação do transporte aéreo no plano
internacional e o interesse em uniformizar as fontes incidentes sobre os respectivos contratos,
estudando-se, em especial, a Convenção de Montreal e a aplicação desta pelas cortes estrangeiras.
Igualmente, no segundo momento, visa-se analisar a legislação brasileira aplicável às relações de
transporte aéreo internacional e a necessidade de harmonização entre as disposições da Convenção de
Montreal e as do Código de Defesa do Consumidor, a fim de assegurar o cumprimento das obrigações
assumidas internacionalmente e, ao mesmo tempo, a proteção do consumidor em virtude da
relevância do assunto, advinda do julgamento da tese, com repercussão geral, relativa ao Tema 210
do Supremo Tribunal Federal. Propõe-se, para permitir a aplicação harmônica e conjunta dessas duas
fontes normativas, a utilização do método da Teoria do Diálogo das Fontes, ou diálogo entre as fontes
em aparente conflito, desenvolvido por Erik Jayme e por Claudia Lima Marques, por meio do qual se
pretende concretizar o princípio pro homine.
Direito fundamental econômico das fintechs: desenvolvimento brasileiro
Authors: Merlone Nicholas
Published: March 2021

O estudo em comento objetiva refletir e trazer contribuições teóricas e práticas acerca das relações
entre fintechs e micro e pequenas empresas. Trata assim do direito fundamental econômico das
fintechs e de startups, inovações, empreendedorismo e Direito, além de trazer os desafios e os impactos
jurídicos e tecnológicos envolvidos na questão, considerações sobre micro e pequenas empresas, notas
sobre a gestão de Pequenas e Médias Empresas de base tecnológica, cobertura de eventos sobre as
novas tecnologias no sistema financeiro e, por fim, atividade de inteligência aplicada ao tema com
a segurança da informação. Para tanto, foram realizadas revisões bibliográficas por meio de obras
físicas consultadas, revistas especializadas e fontes eletrônicas governamentais. Efetuou-se, também,
trabalho de campo para cobrir as últimas novidades da pauta. O resultado alcançado se traduz em
um cenário onde é possível verificar implicações decorrentes das relações citadas, nas vidas social
e econômica do País, com destaque para o desenvolvimento nacional e redução das desigualdades
sociais, por intermédio da adequação do Direito aos casos concretos, pelo uso de novas tecnologias e da
atividade de inteligência, bem como pela observância da segurança da informação.
Antecipação da proibição de contratar com o poder público na lei de improbidade administrativa
Authors: Zago Fábio Bragança
Published: March 2021

Este estudo versa sobre a sanção legal de proibição de contratar com o poder público, sob o enfoque da Lei 8.429 de 1992 (Lei de Improbidade Administrativa – LIA). Pretende-se descrever os posicionamentos doutrinários e jurisprudenciais atinentes ao tema, sob uma metodologia dogmática, bibliográfica e dedutiva. Primeiramente, foi traçado um breve panorama constitucional sobre a LIA para, ainda no primeiro capítulo, discorrer sobre a jurisprudência do Superior Tribunal de Justiça relacionada ao alcance da referida sanção no âmbito da Lei 8.666 de 1993, a Lei de Licitações e Contratos, e da Lei 8.429 de 1992. Discutiram-se três possibilidades para a aludida sanção: a possibilidade de ser aplicada, liminarmente, por força do poder geral de cautela, reforçado pelo novo Código de Processo Civil brasileiro; a possibilidade de aguardar a fase decisória e, ainda, a de aguardar o trânsito em julgado. Concluiu-se que é possível aplicar à pessoa jurídica a sanção legal de proibição de contratar com a Administração Pública já no momento de recebimento da petição inicial, liminarmente, sem incorrer em indevida antecipação de pena ou ofensa ao princípio da legalidade.
O uso de medicamentos à base de canabinoides no brasil: um estudo de caso
Authors: Lopes Leite George , Alencar Frederico
Published: March 2021

Este artigo busca analisar a criminalização do cultivo da maconha para fins medicinais, abordando

argumentos de natureza política, jurídica e terapêutica. Parte-se do estudo de um caso concreto em que

o Tribunal de Justiça do Distrito Federal e dos Territórios (TJDFT) concedeu salvo-conduto a pais para

cultivarem Cannabis sativa L. e produzirem canabidiol (CBD) e tetraidrocanabinol (THC), necessários

ao tratamento da filha, diagnosticada aos três anos de idade com síndrome de Silver-Russel (SSR). Ela

já tinha dezessete anos de idade quando um médico prescreveu remédios à base de CBD e THC, não

vendidos no Brasil, mas livremente produzidos alhures: Mevatyl, no Reino Unido, e Sativex, no Canadá.

A importação foi autorizada pela ANVISA e os pais obtiveram em juízo o reembolso das despesas.

Todavia, nem sempre o produto importado chegava no tempo oportuno. Examinam-se os aspectos

políticos da criminalização do cultivo de maconha, relatando-se a rotina da paciente, acometida por

dores crônicas e convulsões diárias. Os sintomas eram tratados com botox, cirurgias ortopédicas,

Rivotril e analgésicos à base de opiáceos. Analisam-se também o Direito Comparado, as leis do país, e,

especialmente, o artigo 24 do Código Penal, tratando do estado de necessidade, inclusive a subdivisão

da doutrina, estudando a excludente sob os aspectos justificante e exculpante. Chega-se, enfim, à

conclusão de que a conduta dos pais não poderia ser considerada crime e que o salvo-conduto deveria

ser – como foi – concedido.
Prescrição nas ações de regresso – caso em que o agente público é o causador de dano a terceiros
Authors: Faleiros Júnior José Luiz de Moura , Miranda Frederico Cardoso de
Published: March 2021

O presente trabalho analisa a prescrição nas ações de regresso do Estado no caso em que este é condenado ao pagamento de indenização por danos a terceiros, sendo que tais danos advêm da ação de agentes públicos. A hipótese de pesquisa se lastreia na possibilidade e na obrigação do Estado em propor a ação regressiva e, ainda, apontar se sobre essa ação se aplica o instituto da prescrição. Caso possa ser aplicado esse instituto, qual o prazo de prescrição, com a intenção de reviver o tema e saber se o entendimento da jurisprudência permanece inalterado. A análise pautar-se-á, cientificamente, pelo método de abordagem histórico-sociológico, com implementação de substratos de pesquisa bibliográfico-doutrinária da interação entre o direito administrativo e o constitucional, além de estudos jurisprudenciais. Ao final, procurar-se-á extrair compreensão coesa quanto à possibilidade ou à impossibilidade de prescrição da ação regressiva do Estado contra o agente causador do dano.
O direito sistêmico no combate a novos episódios de violência doméstica e familiar contra a mulher
Authors: Gonçalves Paula Regina de Oliveira
Published: March 2021

O Direito Sistêmico é uma nova forma de aplicação das normas constantes do ordenamento jurídico pátrio que busca resolver a origem remota dos conflitos de interesse submetidos a julgamento nos processos levados ao Poder Judiciário. Percebeu-se que a simples prolação de sentenças, em determinadas situações, não era suficiente para pacificar as relações estabelecidas entre os litigantes, pois o conflito interpessoal permanecia mesmo após o término das ações judiciais. Tal situação é visivelmente identificada nos casos de violência doméstica e familiar contra mulheres, nos quais a mera imposição de pena aos agressores se mostra insuficiente para eliminar a ocorrência de novos episódios de agressividade entre os casais. A assertiva fundamenta-se principalmente na análise dos dados estatísticos extraídos do Sistema de Automação da Justiça – SAJ, especificamente na comarca de Dourados-MS, os quais apontaram a existência de um percentual de aproximadamente 20% (vinte por cento) de reiterações de pedidos de medidas protetivas de urgência envolvendo um mesmo casal. A proposta apresentada no presente artigo tem por finalidade a realização de um trabalho paralelo à aplicação do Direito Penal convencional aos casos de violência doméstica e familiar contra a mulher, com o intuito de buscar a pacificação definitiva dos casais e a redução da reincidência de situações dessa natureza. Para a elaboração do presente artigo foi utilizada pesquisa bibliográfica, documental e descritiva, com a utilização do método dedutivo de pesquisa, partindo da análise dos preceitos legais e regulamentares até a sua efetiva concretização na sociedade.
Curadoria especial: influências do estatuto da pessoa com deficiência e cpc/2015
Authors: Barretto Fabrício do Vale
Published: March 2021

O presente trabalho pretende examinar as influências do Estatuto da Pessoa com Deficiência e do CPC/2015 sobre a curatela especial processual. Para tanto, foi utilizada metodologia de pesquisa legislativa e essencialmente bibliográfica no campo dos Direitos Civil e Processual Civil. Inicialmente, realiza-se um breve estudo sobre a curadoria especial e sua distinção das figuras assemelhadas. Em seguida, estuda-se a novidade disposta no art. 72, parágrafo único, do CPC/2015 e a solução para o problema estrutural da ausência de Defensoria Pública no interior do País. Ato contínuo, trata-se do novo regime das capacidades e da necessidade de nomeação de curador especial. Posteriormente, aborda-se a curatela compartilhada e a atuação do curador especial em negócio processual, no processo da tomada de decisão apoiada e em levantamento de curatela, em face da vigência das regras estatutárias, na defesa dos interesses de pessoas com deficiência. Conclui-se que há casos em que o novel regramento altera o exercício do curador à lide, mas sem repercussão, e outros para os quais surgem novas hipóteses de atuação ou sensíveis alterações.
APRESENTAÇÃO - VOLUME 111, N. 1, DA REVISTA DE DOUTRINA E JURISPRUDÊNCIA - RDJ
Authors: De Santis Sandra
Published: March 2021

Os textos publicados nesta e nas demais edições da RDJ, enviados por autores de todo o País, são selecionados por meio do método double blind review, processo de avaliação realizado por especialistas do Direito com elevada titulação acadêmica, que escolhem os artigos – sem identificação de autoria – para publicação. Neste volume, convidamos o Dr. Antonio Henrique Graciano Suxberger, Pós-Doutor em Democracia e Direitos Humanos pelo Ius Gentium Conimbrigae da Universidade de Coimbra, Professor Titular do Programa de Mestrado e de Doutorado do Centro Universitário de Brasília – UniCEUB e Promotor de Justiça do Ministério Público do Distrito Federal e Territórios, para escrever o artigo destaque, o qual versa sobre tema muito atual e interessante, o Juiz das Garantias.
Vedação de progressão de regime aos integrantes de organização criminosa
Authors: Ferreira dos Santos Carlos Eduardo
Published: March 2021

O estudo versa sobre as modificações advindas do acréscimo do § 9º ao art. 2º da Lei 12.850, de 2 de agosto de 2013. Em razão da nova redação conferida pela Lei 13.964/2019, vedam-se a progressão de regime, o livramento condicional e outros benefícios prisionais aos condenados por integrarem organização criminosa ou por terem cometido crimes por meio de organização criminosa com a qual ainda mantenham vínculo associativo. A problemática consiste em identificar se a proibição de progressão de regime se assemelha a alguma modalidade de sistema penitenciário, se as referidas mudanças são constitucionais e se respeitam os direitos humanos. A metodologia utilizada baseia-se na análise de normas, nacionais e internacionais, bem como na pesquisa de doutrina e jurisprudência. Ao final desse estudo, verifica-se que a nova lei se aproxima do sistema penitenciário pensilvânico ou celular; atende ao princípio da individualização da pena, sendo constitucional e compatível com o princípio da convencionalidade de normas internacionais, mormente com as Regras Mínimas das Nações Unidas para o Tratamento de Reclusos e a Convenção Contra a Tortura e Outros Tratamentos ou Penas Cruéis, Desumanos ou Degradantes.
O direito animal brasileiro sob a perspectiva da jurisprudência do TJDFT
Authors: Regis Arthur Henrique de Pontes
Published: March 2021

O Direito Animal brasileiro possui como fonte a vedação constitucional de submeter animais à crueldade, reconhecendo a senciência e a dignidade animal. Acrescente-se que o Direito Animal se configura como disciplina acadêmica autônoma que não se confunde com o Direito Ambiental (embora existam elementos compartilhados), ocorrendo a sua evolução com a produção doutrinária, legislativa e jurisprudencial. Nesse contexto, a presente pesquisa objetivou identificar e analisar de que forma as questões versando sobre os animais têm sido demandadas e debatidas no Tribunal de Justiça do Distrito Federal e dos Territórios – TJDFT (no século XXI). A pesquisa possui intuito exploratório e descritivo, realizando-se a busca de informações no banco de dados de jurisprudência do TJDFT. Os resultados obtidos com base em análise documental permitiram vislumbrar o panorama da questão animal que subsiste, ainda, nas produções oriundas do TJDFT, onde impera o viés antropocêntrico, que ainda permeia o sistema normativo brasileiro. Na seara cível, a maioria dos acórdãos versavam sobre a temática da responsabilidade civil e, no campo criminal, sobre a prática de crimes ambientais. Não foi possível identificar, nas decisões colegiadas proferidas pelo Tribunal de Justiça, elementos que permitam uma evolução do Direito, o que demonstra a não incorporação dos elementos do Direito Animal.
Execução da pena sem o trânsito em julgado da sentença condenatória, stf e recentes alterações legislativas
Authors: Azevedo Barbara Lima Rocha
Published: March 2021

O artigo versa sobre a possibilidade, ou não, da execução da pena sem o trânsito em julgado da sentença condenatória, acerca dos os posicionamentos do Supremo Tribunal Federal (STF) e as recentes alterações legislativas. Além disso, pretende demonstrar, por meio do método qualitativo e do método quantitativo, que a discussão acerca do tema, ao contrário do que se imagina, não é recente. A coleta de dados se deu por meio de abordagem de mudanças legislativas e decisórias, com análise de votos dos ministros da Suprema Corte em julgamentos considerados relevantes, destacando as argumentações mais comuns para ambos os lados. Por fim, tratou de alterações legislativas recentes, bem como de legislações em discussão no Congresso Nacional. Ao final, o cotejo dessas informações permitiu a verificação de que muitas das críticas constantemente dirigidas ao STF são desconectadas da realidade e carregam forte teor populista.
Diseño y Construcción de Prácticas para el Estudio de Movimiento Ondulatorio
Authors: Martínez García Sebastián , Salazar Diego Fernando , Osorio Ramírez Andrés Felipe , Bohórquez Santiago Leonardo , Gallego Becerra Hugo Armando
Published: March 2021

Este libro es el resultado del esfuerzo conjunto de todos los que formamos parte del grupo de investigación DICOPED, un grupo de trabajo basado en el fruto de ideas, esfuerzo e investigación, producto del reconocimiento y del apoyo vital que nos ofrecen las personas que nos estiman, para poseer la fuerza y energía que nos anima a crecer como investigadores y profesionales. La concepción de este proyecto está dedicada a la Vicerrectoría de Investigaciones, Innovación y Extensión de la Universidad Tecnológica de Pereira, por las convocatorias internas para la financiación de proyectos de investigación, innovación o desarrollo tecnológico de los años 2016 - 2018. Queremos dar las gracias también a todas esas personas que nos aportaron, en especial a aquellos que nos abrieron las puertas y compartieron sus conocimientos para la elaboración de los productos expuestos en este libro; especialmente, a Angélica Franco Arias y a nuestro editor Jeiner Orlando Moreno Soto. Sabemos que estas palabras ...
Refractory chylothorax due to thoracic duct stenosis in Noonan syndrome with RIT1 gene mutation: a case report and literature review
Authors: yang Lei , guo Ying , Xu Xinyi , Zhang Xu , Gao Wei , liu tingliang
Published: March 2021

The occurrence of Noonan with refractory chylothorax with RIT1 gene
mutation is very rare. The right lymphatic vessel and thoracic duct were
compressed by the surrounding tissue, resulting in obstruction. After
releasing the surrounding tissue, the chylothorax disappeared.
Is Laparoscopic Adrenalectomy for Pheochromocytoma a Safe and Effective Surgery in Geriatric Patients?
Authors: Gunseren Kadir , Çiçek Mehmet Çağatay , Bolat Deniz , Yeni Sezgin , Vuruskan Hakan , Gul Ozen Oz , Yavascaoglu Ismet
Published: March 2021

Objectives: In this study, we aimed to evaluate the haemodynamic changes
of laparoscopic adrenalectomy (LA) in geriatric patients with
pheochromocytoma (PHEO). To the best of our knowledge, it is the first
study evaluating the haemodynamic outcomes of pure LA in this patient
population. Methods: Between 2000-2020, data of 350 patients who
underwent single-side transperitoneal LA were reviewed retrospectively.
Patients with a histopathological diagnosis of PHEO were enrolled and
classified into two groups according to their ages at the date of
surgery. Older than 65 years were accepted as elderly according to the
World Health Organisation recommendations. Results: Overall 54 patients
underwent single side LA for PHEO. Fifteen patients were enrolled in the
elderly group and 39 in the young group. There were no significant
differences regarding the operation site (0.564) and tumour size
(0.878). There were no statistically significant differences in terms of
perioperative outcomes, such as mean anaesthesia and operation times,
blood loss and haemodynamic changes. Regarding postoperative outcomes;
there were no statistically significant differences in mean
hospitalization and intensive care unit times. In 1 patient in each
grade-1 (prolonged ileus, managed with medical treatment) and grade 2
complication (transfusion during surgery) observed in the elderly and
young groups, respectively (p=0.498). Conclusion: Laparoscopic
adrenalectomy in elderly patients with PHEO is as safe and effective as
in younger patients. One of the most important conditions for achieving
good perioperative and postoperative outcomes in the elderly patient
population with this challenging surgery is the multidisciplinary
approach.
The effect of vesicourethral anostomosis technique on functional results in retropubic radical prostatectomy
Authors: Kizilay Fuat , Kalemci Serdar , Simsir Adnan
Published: March 2021

Aim We aimed to compare the functional results of two different
vesicourethral anostomosis (VUA) techniques used in retropubic radical
prostatectomy (RRP). Methods A total of 476 patients including the first
group with 4 focal VUA at 12-, 3-, 6-, and 9-o’clock positions (n = 288)
and the second group with 6 focal VUA at 12-, 2-, 4-, 6-, 8- and
10-o’clock (n = 188) were included in the study. Perioperative data and
erectile function and continence status over a 12-month period were
compared. Results Demographic and perioperative data were similar
between the two groups. The proportion of patients with VUA stricture in
the first group was significantly higher than in the second group (5.1%
vs 3.2%, p = 0.017). The mean time to stricture development was also
shorter in the first group (48.9 vs 74.3 days, p = 0.002). In the second
group, the proportion of continent patients at the sixth and twelfth
months was higher than the first group (79.3% vs 62.8%, p
<0.001; 92.4% vs 81.3%, p = 0.032, respectively). There was
no significant difference between the two groups in terms of the
proportions of potent patients (p = 0.194 for 6 months and p = 0.351 for
12 months). Conclusions Better continence results can be obtained with
the six-focus VUA compared to the four-focus technique. The number of
anostomotic sutures in VUA can affect functional results and may be a
decisive factor for surgeons who focus on functional results as well as
oncological results.