bluuebunny/crossref_metadata_2025 huggingface dataset:
TÜRKİYE’NİN II. KARABAĞ SAVAŞI'NDAKİ ROLÜNÜN ULUSLARARASI HUKUK AÇISINDAN DEĞERLENDİRİLMESİ
Authors: ÖĞÜT Selman , ÜLKÜ Rümeysa
Published: January 2023

Karabağ sorunu sebebiyle Güney Kafkasya’da Azerbaycan ile Ermenistan arasında uzun süredir devam eden problem, 27 Eylül 2020 yılında başlayan II. Karabağ Savaşı ile 44 gün süren bir çatışma hâlini almıştır. Karabağ’ın işgalinin tarihsel kökenini bilmemiz II. Karabağ Savaşı’na giden süreci anlamamız için önemlidir. Ermenistan, 30 yıl boyunca Azerbaycan toprağı olan Karabağ ve çevresini işgal altında tutmuştur. Bu süreçte de tüm çözümlere ve barış yollarına kendini kapatmıştır. Hatta Ermenistan’ın birçok defa ateşkes ihlalinde bulunduğu bilinmektedir. Bununla birlikte uluslararası hukuka uygun olmayan birçok savaş suçu işlemiştir. Daha önce yaşananlara benzer bir şekilde II. Karabağ Savaşı’nda da Ermenistan Silahlı Kuvvetleri saldırılarda bulunmuştur. Ayrıca yine Ermenistan’ın bu savaşta birçok savaş suçu işlediği görülmüştür. Adil bir yargılamanın yapılabilmesi için tüm bu süreç Uluslararası Ceza Mahkemesi’ne taşınmalıdır. 9 Kasım 2020’de Azerbaycan ile Ermenistan arasında imzalanan ateşkes antlaşması ile savaş sona ermiş, Azerbaycan askeri üstünlük sağlamış ve önemli haklar elde etmiştir. Türkiye ise Azerbaycan’ın yanında olmuştur. Azerbaycan da her seferinde Türkiye’nin desteğini görmek istediğini ve birlik olduklarını belirten açıklamalar yapmış, daha önce yapılan antlaşmalar gereğince Türkiye’den özellikle İHA/SİHA noktasında yardım almıştır. Türkiye, savaş esnasında ve savaştan sonra Azerbaycan’a siyasi, askerî ve ekonomik birçok yardımda bulunmuştur. Bu çalışma Karabağ’ın ve Karabağ savaşlarının tarihî kökenlerinden bahsetmekle birlikte, uluslararası hukuk açısından Türkiye’nin II. Karabağ Savaşı’ndaki rolünün hukuka uygunluğunu tarihî ve güncel uluslararası antlaşma ve belgelerden yararlanarak açıklamaktadır.
AROMATICITY OF AZA AROMATIC MOLECULES: PREDICTION FROM HÜCKEL THEORY WITH MODIFIED PARAMETERS
Authors: Sutjahja Inge , Sudarso Yuanita , ‘Ulhaq Shofi , Yutomo Erik
Published: January 2023

Hückel theory is a simple and powerful method for predicting the molecular orbital and the energy of conjugated molecules. However, the presence of nitrogen atoms in aza aromatic molecules alters the Coulomb and resonance integrals owing to the difference in electronegativity between nitrogen and carbon atoms. In this study, we focus on acridine and phenazine. Further correction is implemented based on the ring current model, thus revealing the change in resonance integral for the carbon–carbon bond along the bridge of the molecule. The Hamiltonian of the π–electron system in the Hückel method is solved using the HuLiS software. Various geometry-based aromaticity indices are used to obtain the aromaticity indices of the two non-equivalent rings. For further evaluation, the results for bond lengths are used to calculate the associated bond energy. Considering the carbon–hydrogen (CH) bonds, the total molecular energy is compared with the experimental heats of formation for a number of benzenoid hydrocarbons and aza aromatics, in addition to the two studied molecules. Finally, the correlation between the nitrogen atom on the aromaticity index and the ring energy content is evaluated to determine to which extent the Hückel model agrees with previous experimental and advanced computational studies.
Percepção do BIM por projetistas do setor da AECO em Pernambuco
Authors: Vasconcelos Bianca Maria , Germano João Victor Menezes de Albuquerque
Published: January 2023

O Building Information Modeling (BIM) é uma metodologia, atrelada a políticas, processos e tecnologias, que veio para transformar o mercado da Arquitetura, Engenharia, Construção e Operações (AECO), estabelecendo novos fluxos de trabalho durante todo o ciclo de vida da edificação. Existem diversos níveis de maturidade dessa metodologia, variando de acordo com a complexidade do projeto elaborado. Nesse contexto, o presente trabalho teve como objetivo analisar a percepção dos projetistas de escritórios de projetos atuantes em Pernambuco sobre a implementação do BIM no Estado, através de uma pesquisa de opinião. Por meio da aplicação de questionário e tratamento dos dados, foram elencados os principais desafios da implementação do BIM, os níveis em que estão sendo trabalhados e os aspectos positivos da utilização do BIM, traçando a percepção do mercado de trabalho sobre a aplicação dessa metodologia no Estado de Pernambuco. Os resultados desta pesquisa de opinião evidenciaram que os maiores desafios da implementação do BIM, segundo os projetistas atuantes no Estado, estão ligados ao fator tempo, tanto no treinamento dos funcionários, quanto no estabelecimento de um novo fluxo de trabalho. Outrossim, essa metodologia auxilia na obtenção de aspectos positivos, sendo citados, principalmente, o desenvolvimento de um produto (projetos) de melhor qualidade e facilidade na geração de vistas tridimensionais e de elevações.
Hydrogen Sulfide (H2S): As a Potent Modulator and Therapeutic Prodrug
in Cancer
Authors: Faris Pawan , Negri Sharon , Faris Delia , Scolari Francesca , Montagna Daniela , Moccia Francesco
Published: January 2023

Hydrogen sulfide (H2S) is an endogenous gaseous molecule present in all living
organisms that has been traditionally studied for its toxicity. Interestingly, increased
understanding of H2S effects in organ physiology has recently shown its relevance as a
signalling molecule, with potentially important implications in variety of clinical disorders,
including cancer. H2S is primarily produced in mammalian cells under various enzymatic
pathways are target of intense research biological mechanisms, and therapeutic effects
of H2S. Herein, we describe the physiological and biochemical properties of H2S,
the enzymatic pathways leading to its endogenous production and its catabolic routes. In
addition, we discuss the role of currently known H2S-releasing agents, or H2S donors, including
their potential as therapeutic tools. Then we illustrate the mechanisms known to
support the pleiotropic effects of H2S, with a particular focus on persulfhydration, which
plays a key role in H2S-mediating signalling pathways. We then address the paradoxical
role played by H2S in tumour biology and discuss the potential of exploiting H2S levels
as novel cancer biomarkers and diagnostic tools. Finally, we describe the most recent preclinical
applications focused on assessing the anti-cancer impact of most common H2S-releasing
compounds. While the evidence in favour of H2S as an alternative cancer therapy
in the field of translational medicine is yet to be clearly provided, application of H2S is
emerging as a potent anticancer therapy in preclinical trails.
Contemporary Progress in the Applications of Iron-based Magnetic Nanoparticles in
Multicomponent Synthesis: A Review
Authors: Srivastava Neelanjana , Verma Monika , Thakur Ajay , Bharti Ruchi , Sharma Renu
Published: January 2023

In recent decades, organic synthetic reactions have advanced towards a greener and sustainable reactions by the usage of magnetic nanoparticles (MNPs). Such nanoparticles can be quickly recovered and reused in various organic syntheses. MNPs are a sustainable methodology while encountering environmental and profitable advantage. Due to their properties, MNPs have broad impacts on multiple fields. For instance, their size and magnetic properties have significant implications for various biomedicine, environmental remediation projects, and catalysis. MNPs are an alternative to conventional materials. These are smaller and have a high surface area that allows them to have copious catalytic sites. Amongst various MNPs, iron-based nanoparticles are being profoundly explored in different multicomponent reactions (MCRs). A convergent reaction, which retains most of the significant atoms of the starting components. This investigation targets to equip its readers a brief appertaining to nanoparticles, their processing, and characterization and summarize the evolution in applications of Iron-based MNPs in multicomponent synthetic procedures since 2010.
Use of Lithium in Pediatric Bipolar Disorders and Externalizing Childhood-
related Disorders: A Systematic Review of Randomized Controlled
Trials
Authors: Janiri Delfina , Moccia Lorenzo , Montanari Silvia , Zani Valentina , Prinari Claudia , Monti Laura , Chieffo Daniela , Mazza Marianna , Simonetti Alessio , Kotzalidis Georgios D. , Janiri Luigi
Published: January 2023

Background:

Lithium is the standard treatment for bipolar disorders (BD) in adults. There
is a dearth of data on its use in the pediatric age. This review aimed to investigate the use of lithium in
pediatric bipolar disorder (BD) and other externalizing childhood-related disorders.

Methods:

We applied the Preferred Reporting Items for Systematic Reviews and Meta-analyses criteria
(PRISMA) to identify randomized controlled trials evaluating the use of lithium in pediatric (BD),
conduct disorder (CD), attention deficit hyperactivity disorder, oppositional defiant disorder, and disruptive
mood dysregulation disorder. The primary outcome of our study was to evaluate the efficacy
of lithium compared to a placebo or other pharmacological agents. The secondary outcomes were acceptability
and tolerability.

Results:

Twelve studies were eligible, 8 on BD and 4 on CD. Overall, 857 patients were treated with
lithium. No studies for externalizing disorder diagnoses were identified. Regarding BD patients
(n = 673), efficacy results suggested that lithium was superior to placebo in manic/mixed episodes but
inferior to antipsychotics. Lithium efficacy ranged from 32% to 82.4%. Results on maintenance need
to be expanded. Comorbidity rates with other externalizing disorders were extremely high, up to
98.6%. Results in CD patients (n= 184) suggested the efficacy of lithium, especially for aggressive behaviors.
No severe adverse events directly related to lithium were reported in BD and CD; common
side effects were similar to adults.

Conclusions:

This systematic review supports the use of lithium in BD and CD as an efficacious and
generally well‐tolerated treatment in the pediatric age. However, evidence is limited due to the paucity
of available data.
QbD Assisted Development and Validation of UV Spectroscopic Method in
Estimation of Silymarin
Authors: Mishra Ashwini Kumar , Neha S.L. , Rani Laxmi , Dewangan Hitesh Kumar , Sahoo Pravat Kumar
Published: January 2023

Background:

Silymarin is a flavonoid utilised in liver dysfunction for years; new studies have
emphasised its potential utility as a therapy for nanoparticulate targeting in many other disorders. In order
to establish the product quality of such compounds, researchers have been trying to develop a robust
method of analysis, but the methods developed till now are too expensive and time-consuming. Here we
proposed quality by design-assisted development and validation of the UV spectroscopic method using
Design-Expert® software in the estimation of Silymarin for fabrication of nanoparticulate formulations,
which is simple, accurate, cost-effective and non-tedious.

Aim:

The proposed method is a simple, new, robust, accurate, and precise UV visible spectroscopic
technique for estimating silymarin produced in nano-formulations utilising an analytical quality by design
(AQbD) approach.

Methods:

A UV spectrophotometric technique was established, as maximum absorption (287.7) was
measured using a Shimadzu UV-1800 double-beam UV visible spectrophotometer. The characterization
of silymarin was done by melting point, DSC and FTIR techniques. The two critical method variables
chosen were scanning speed and sample interval to be analysed by the design of experiment methodology
utilizing the central composite design principle, which shows robustness and optimized technique involved
in this work.

Results:

The spectroscopy technique was developed and validated as per International Conference of
Harmonization recommendations. The Beer's-Lambert rule was followed in a series of 2-12 μg/ml dilution
increments, with a correlation value of R2 = 0.999. The method's linearity was shown to be excellent
across the concentration range. The percent recovery of the current method approach was determined to
be within the confidential limitations, i.e., less than 2% expressed as % RSD, and the methodology was
proved to be precise at inter and intraday variations (% RSD). The LOD and LOQ were found to be 0.264
μg/ml and 0.801 μg/ml which were also determined correctly. During specificity testing, no interfering
peaks were found.

Conclusion:

This UV approach has been used successfully to determine the quantity of silymarin present
in the nanoparticulate formulation, which can be used for testing its other pharmaceutical dosage forms.
Hydrogel-based Treatment Strategies to Accelerate Diabetic Foot Ulcer Healing
Authors: Mehta Sadgi , Wadhwa Sheetu , Nayak Sammisla R. , Kumar Rajesh
Published: January 2023

A diabetic foot ulcer is a chronic clinical manifestation of diabetes that exacerbates the condition of a patient and has a considerable socioeconomic impact. A diabetic foot ulcer (DFU) impacts around 25% of patients with diabetes mellitus at a certain point in their lives, and the underlying cause of the condition appears to be linked to neuropathic, ischaemic, and/or neuroischaemic pathologies. For the effective treatment of DFU, a variety of conventional treatments are used. However, in recent years, a range of innovative materials have been studied to bolster standard treatment tactics and promote the desired biological response by transcending the impediments of current wound healing approaches. Inorganic/organic hydrogel hybrids for tissue regeneration are among the most promising materials. This review article outlines the current treatment options for DFU, applications of hydrogel with an emphasis on wound healing, polymeric materials used to fabricate hydrogel, and the role of emerging technologies.
Sleep Disturbances in Children and Adolescents with Autism
Spectrum Disorder: An Overview for Clinicians
Authors: Gupta Mayank , Gupta Nihit , Fradkin Yuli , Petti Theodore
Published: January 2023

Background:

Sleep disorders in autism spectrum disorders (ASD/SD) are
distinct, broad, and highly variable clinical entities that ubiquitously affect core
symptomatology, development of comorbid disorders, and overall quality of life for affected
children and families. High genetic predisposition and the presence of co-occurring
disorders present significant challenges in assessment and appropriate interventions.

Objective:

The study aimed to review the best available evidence and address the clinical
gaps in the knowledge about sleep disorders in children and adolescents with autism
spectrum disorders.

Methods:

The review provides a comprehensive literature search of 1622 articles and
summarizes 110 selected for empirical evidence to methodically consider critical aspects of
sleep disorders in ASD for informing clinicians of useful information.

Results:

Clinicians have insufficient guidance and support to effectively manage sleep
disruptions in ASD youth in practice. Prevalence of sleep disruption in ASD, close to 80%, is
characterized by unique subtypes, including but not limited to obstructive sleep apnea,
circadian rhythm disorders, and sleep-related movement disorders. Greater awareness of sleep
disruption, its neurodevelopmental basis, scope, and impact allows for improved treatment and
prevention efforts of these conditions, and is critical for clinical practice and future research.
The bidirectional nature of disruptive sleep and ASD is considered a major area requiring
further clarification.

Conclusion:

Clinician-friendly screening tools are needed for everyday office practice to
identify ASD/SD conditions and interventions, and mitigate harmful effects.
Psychoeducational and cognitive-behavioral approaches for improving and supporting
healthy sleep hygiene, considered the first line of treatment, are detailed. The weak database
for the use of psychopharmacologic agents is summarized, and the strength of prescribing
prolonged-release melatonin for optimal results is described. The promise of other
medications is discussed.
Experimental and Theoretical Investigations on the Antibacterial Activity
of Some Bromoaniline Compounds
Authors: Longkumer Naruti , Richa Kikoleho , Karmaker Rituparna , Singha Basanta , Sinha Upasana Bora
Published: January 2023

Background:

Test substrates are routinely used in laboratories to test the efficacy of
various reactions, and while many substrates have found success as test substrates, not much is
known about their potential intrinsic properties. On that note, some bromoaniline compounds were
synthesized and repurposed by studying their antibacterial activity.

Methods:

The in-vitro antibacterial tests were done against S. aureus, K. pneumoniae, B. subtilis,
and E. coli. Tests were carried out to understand the mode of action of the compounds where
changes in permeability and integrity of cell membrane resulting in the leakage of UV absorbing
materials were observed. Computational studies were performed by employing density functional
theory (DFT) in the Gaussian09 software for determining the reactivity of the studied compounds.
Molecular docking studies were executed to define the interaction of the synthesized compounds
with microbial target proteins, Dihydrofolate reductase (PDB ID: 3SRW) and DNA gyrase subunit
B (PDB ID: 1KZN).

Results:

The compound’s response to the mode of action tests showed alteration in the membrane
permeability and its antimicrobial effectiveness at different pH contributed it to being a potential
antibiotic. The results of DFT studies revealed that the molecular descriptors indicate better
reactivity of compound 8b which is in agreement with the experiments performed. Molecular
docking studies revealed that interactions of the compounds at the active sites of target proteins
depict that the compounds are likely to bind to the protein enhancing their potential as antibacterial
agents.

Conclusions:

This work concludes that simple molecules synthesized effortlessly through a simple
and environmentally benign pathway, can pose as a good therapeutic agent
Analysis of Temperature Field of Silicone Heating Plate based on
COMSOL
Authors: Zhang Yanqin , Lu Wanli , Wang Mulan , Qian Yefeng
Published: January 2023

Background:

In the manufacturing process of lithium batteries for new energy vehicles, silica
gel plates shall be used as heating and thermal insulation. This paper takes four groups of silica gel
heating plates with different specifications as the research object to predict the temperature distribution
of silica gel plates and provide theoretical references for the manufacturing engineering of silica gel
heating plates.

Objective:

Combined with the heat transfer theory, the temperature distribution of silica gel heating
plate is predicted by simulation calculation, and the feasibility of this method is verified by experiments,
which provide references for the manufacturing engineering of silica gel heating plate.

Methods:

This article takes four groups of silica gel plates with different specifications as the research
objects, and 30 temperature measurement points are collected. The simulation results are compared with
the experimental results to verify the method’s feasibility.

Results:

The average error between the experimental and simulation results was ± 2.6°C, which was in
line with the expected effect of silica gel plates. This paper’s research process and method can provide
theoretical references for the manufacturing engineering of silica gel heating plates.

Conclusion:

Taking the silica gel heating plate provided by the factory as the research object, according
to the heat transfer theory, the thermal conductivity equation of the silica gel plate was established,
which provided a theoretical model for simulation analysis. The experimental results show that the average
error between the simulation and experimental results is ±2.6°C, which is in line with the empirical
expectation, and the method is feasible. This paper’s research process and practice can provide theoretical
reference for the manufacturing engineering of silica gel heating plate.
Tumour Markers in Clinical Use
Authors: Gamage Sujani M. K. , Ranaweera Chamath D. , Cheng Tracie T. , Aktar Sharmin , Gopalan Vinod , Islam Farhadul
Published: January 2023

Despite ever-growing experimental evidence for the utility of a wide range of tumour markers, only a handful are understood to be useful in clinical applications. Tumour markers are useful for screening and diagnosis of cancers, prognostication, guiding treatment pathways and post-treatment surveillance studies. The tumour makers play a significant role in cancer care and the markers included in the current treatment guidelines will be discussed in detail in this chapter. The utility of the tumour markers in the management of colorectal, breast, thyroid, hepatobiliary, pancreatic, ovarian, testicular, neuroendocrine and prostate cancer are detailed herein to provide an update on the current use of tumour markers in the clinical settings. 
Circulating Tumour DNA: A Promising Cancer Biomarker
Authors: Aktar Sharmin , Kumar Das Plabon , Gopalan Vinod , King-yin Lam Alfred , Islam Farhadul
Published: January 2023

Liquid biopsies, such as tumor-relevant proteins, miRNAs, circulating
tumour cells (CTC) and cell-free DNA (cfDNA), have all been shown to have
promising potential to be used as cancer biomarkers. However, the sensitivity and
specificity of these biomarkers are currently insufficient, prohibiting their widespread
application in clinical practice. Circulating tumour DNA (ctDNA) has received a lot of
attention in recent years as a potential diagnostic and prognostic tool. Since tumours
release genetic material, (i. e. ctDNA) into the bloodstream before they are apparent on
imaging or cause symptoms, thus, ctDNA is one of the most promising liquid biopsy
biomarkers for early diagnosis, prognosis, and treatment monitoring of patients with
cancer. Accordingly, extensive preclinical and clinical research support that ctDNA has
the potential to be considered a novel tool in early cancer diagnosis and prognosis.
Also, ctDNA analysis can reliably predict tumour growth and treatment efficacy, as
well as can aid in targeted therapy. Herein, this chapter will discuss the clinical
significance of ctDNA in the management of patients with cancer as a potential liquid
biopsy biomarker. 
Enzymes: Tumour Associated Biomarker
Authors: Islam Farhadul
Published: January 2023

Enzymes catalyse biochemical reactions and tightly regulate biophysical and
metabolic pathways to maintain cellular homeostasis. However, the unregulated
activity of these enzymes results in metabolic disorders and genetic diseases, including
cancer. In cancer, significant alteration of enzyme levels and/or activity can be detected
during malignant transformation, thus, it can be used as a potential biomarker in
clinical applications. For example, serum levels of lactate dehydrogenase (LDH),
neuron-specific enolase (NSE) and thymidine kinase 1(TK1), alkaline phosphatases
(ALPs), tumour M2-PK, hexokinase (HK), etc., significantly increased in patients with
various cancers, such as metastatic breast cancer, intracranial germ cell tumours,
ovarian serous carcinomas, oesophagus, cervical, gastrointestinal, prostate, renal cell
carcinoma, head and neck and lung cancers. Also, they are associated with various
clinicopathological factors, such as stage, grade, lymph node metastasis, distant
metastasis, etc. In addition, overexpression of carbonic anhydrase XII (CAXII), matrix
metalloproteinases (MMPs) and aldehyde dehydrogenase 1 (ALDH1), in cancer
tissues, is associated with the presence of several cancers and correlated with the
progression of the diseases. Therefore, screening of these enzymes at the point-of-care
settings could facilitate better management of patients with cancer. This chapter
summarizes the roles of cancer associated-enzymes, especially emphasizing their
clinical significance in patients with various cancers. 
Hormones as Cancer Biomarkers
Authors: Kumar Das Plabon , Islam Farhadul
Published: January 2023

Among all the cancer biomarkers, hormones are less discussed despite
having the ability to be used as potential biomarkers in the diagnosis and prognosis of
various cancers. When a tissue, normally produces hormones in lesser quantity,
produces a hormone in excess levels, then hormones can be used as tumour biomarkers.
Sometimes it is also seen that a hormone is produced by the tissue, which is not
normally associated with the secretion of that hormone. For example, calcitonin, a
protein hormone produced by the thyroid gland, is reported to be increased in
production in thyroid carcinoma. Another protein hormone, namely human chorionic
gonadotropin (hCG), is used as a biomarker in choriocarcinoma, testicular tumors, etc.
On the other hand, a lower level of testosterone hormone is found in prostate cancer,
indicating its role in prostate cancer prognosis. There are other peptidase and steroid
hormones, such as insulin, glucagon, estrogen and progesterone which significantly
contribute to various tumours and are used as valuable biomarkers in the diagnosis and
prognosis. Taken into consideration, in this chapter, we discuss the roles of multiple
peptides and steroid hormones in the diagnosis and prognosis of various cancer types. 
Electrochemical and Optical Detection of MicroRNAs as Biomarkers for Cancer Diagnosis
Authors: Zayani Riham , Ben Hassine Amira , Rabti Amal , Raouafi Amal , Raouafi Noureddine
Published: January 2023

According to the miRBase (v 22.1), released on October 2018, there are more than 1900 identified human microRNA mature sequences. MicroRNAs (aka miRNAs or miRs) are a class of short non-coding RNA sequences, which have been detected within the cells or in body fluids. They act as gene expression regulators and intervene in numerous physiologic and development processes. They posttranscriptionally/ translationally regulate expression of some proteins by forming miRNA-induced silencing complex (mRISC) by binding to 3’-UTR regions of the target messenger RNA to inhibit the protein synthesis. It has been noted that up- and down-regulation of miRs are associated with the pathogenesis of several types of human cancers since their target proteins are tumor-suppressive or oncogenic ones. This chapter will present a general summary of miRNA biogenesis, their link to cancer, and biological methods for their detection. Thanks to their ease of use and high sensitivity, electrochemical and optical techniques were used to detect miRNAs with or without the assistance of amplification methods. We will review the state-of-the-art electrochemical and optical methods for their detection, emphasizing the progress achieved in the last five years (2015-2020). Finally, we will present the main advantages, challenges, and future prospects for future research on detecting miRNAs for clinical diagnosis or prognosis in cancers.
O impacto do desenvolvimento da consciência fonológica na aprendizagem da leitura de jovens e adultos
Authors: Marquez Nakita Ani Guckert , Godoy Dalva Maria Alves
Published: January 2023

The article presents results of a research about the infl uence of a teaching phonological awareness skills and grapheme phoneme correspondences program and its impact over adults and young people who where in diff erent stages of learning skills acquirement proposed by Linnea Ehri. Nine students, from an early literacy class at a Youth and Adult Education Center in the city of Rio do Sul – SC - Brazil, were subjects of this study. The intervention research, methodologically applied, was the application of a teaching program which aimed to contribute to the development of the aforementioned skills and knowledge, and two assessments applied at the program beginning and when fi nishing. The qualitative and quantitative analysis data results found shows that after the intervention the research subjects experienced a performance boost on phonological awareness skills, graphemes recognition and reading at all learning stages, especially those who were in transition from the partial alphabetic phase to the alphabetic phase complete. These results suggest that pedagogical practices that promote the graphophonemic correspondences and the phonological awareness development, especially phonemic awareness teaching, can be benefi cial for the reading in young people and adults in the early literacy development process
CORRELATION BETWEEN VITAMIN D DEFICIENCY AND LOW BODY HEIGHT
Authors: Sananta Panji , Aristoteles Aristoteles , Yusman Fauzan , Negoro Satrio Bangun , Bimadi Muhammad Hilman , Cendikiawan Felix
Published: January 2023

The average height of the Indonesians population has increased a few centimeters for the last 50 years, although Indonesians are short. However, a secular trend in height was still unclear. Currently, the Indonesians adult population is averagely shorter than the modern World Health Organization (WHO) reference males and females. Thus, when comparing the height of Indonesian children with several growth measurements, a significant portion of the children is below the critical limit. This review aimed to discuss the correlation between deficiency vitamin D and low body height
COMMUNITY EMPOWERMENT REGARDING â€œONE HOUSE ONE JUMANTIKâ€ PROGRAM IN KARANG BESUKI SUB-DISTRICT, MALANG CITY
Authors: Rakhmani Alidha Nur , Zuhriyah Lilik , Brian Nugraha Rivo Yudhinata
Published: January 2023

In 2016, Indonesia has been launching the â€œIndonesia Sehat'' program which the strategy used is to strengthen health services through a family approach. According to the 2016 Ministry of Health technical guidelines, the larva inspector, also known as Juru Pemantau Jentik (Jumantik), is involved in Jumantik participating by each family. Their role is the same as 3M plus actions including in the inspection, monitoring, and eradication of mosquito larvae for controlling infectious diseases, especially Dengue Fever. The purpose of these activities was to increase community participation to conduct a â€œone house one Jumantik'' program. The study was the quasi-experimental post-test only design that was located in Karangbesuki sub-district, Malang City from August until September 2017. One cluster Rukun Warga (RW) from the Karangbesuki sub-district that consisted of 9 Rukun Tetangga (RT) was chosen as the location. The intervention was in collaboration with Mulyorejo Public Health Center (Pusat Kesehatan Masyarakat / Puskesmas) in Malang. The methods used were ovitrap utilization training and focus group discussion (FGD), health promotion and "one-house one-Jumantik'' training program, also the contest to choose the best RT. The results of this activity succeeded in establishing a Jumantik team in each RT although there was one RT that has not yet succeeded in forming a team. Furthermore, for the sustainability of the program, it is hoped that this program could be improved by collaborating with Mulyorejo Puskesmas staff who monitor activities routinely through the integrated service post (Pos Pelayanan Terpadu / Posyandu).
Siembra, riego y fertilización para la producción de hortalizas en condición
Authors: Jaramillo Noreña Jorge Eliecer , León Pacheco Rommel Igor , Rodriguez Roa Andrea Onelia , Villagrán Munar Edwin Andrés
Published: January 2023

Bajo condiciones protegidas se utilizan sistemas de siembra dependiendo del hábito de crecimiento de las plantas. Entre tanto, el riego en condiciones protegidas debe ser preciso y localizado, utilizándose el riego de cintas por goteo, donde el agua se aplica gota a gota sin necesidad de mojar toda la superficie del suelo y donde cada planta recibe en forma precisa la cantidad de agua y fertilizantes que requiere. Finalmente, la fertilización se debe realizar durante todo el ciclo del cultivo, basado en los requerimientos de cada especie y los análisis de suelo y se realiza a través del fertirriego.
Cues Disseminated by Professional Associations That Represent 5 Health Care Professions Across 5 Nations: Lexical Analysis of Tweets
Authors: Dadich Ann , Wells Rebecca , Williams Sharon J , Taskin Nazim , Coskun Mustafa , Grenier Corinne , Ponsignon Frederic , Scahill Shane , Best Stephanie
Published: January 2023

Background

Collaboration across health care professions is critical in efficiently and effectively managing complex and chronic health conditions, yet interprofessional care does not happen automatically. Professional associations have a key role in setting a profession’s agenda, maintaining professional identity, and establishing priorities. The associations’ external communication is commonly undertaken through social media platforms, such as Twitter. Despite the valuable insights potentially available into professional associations through such communication, to date, their messaging has not been examined.

Objective

This study aimed to identify the cues disseminated by professional associations that represent 5 health care professions spanning 5 nations.

Methods

Using a back-iterative application programming interface methodology, public tweets were sourced from professional associations that represent 5 health care professions that have key roles in community-based health care: general practice, nursing, pharmacy, physiotherapy, and social work. Furthermore, the professional associations spanned Australia, Canada, New Zealand, the United Kingdom, and the United States. A lexical analysis was conducted of the tweets using Leximancer (Leximancer Pty Ltd) to clarify relationships within the discourse.

Results

After completing a lexical analysis of 50,638 tweets, 7 key findings were identified. First, the discourse was largely devoid of references to interprofessional care. Second, there was no explicit discourse pertaining to physiotherapists. Third, although all the professions represented in this study support patients, discourse pertaining to general practitioners was most likely to be connected with that pertaining to patients. Fourth, tweets pertaining to pharmacists were most likely to be connected with discourse pertaining to latest and research. Fifth, tweets about social workers were unlikely to be connected with discourse pertaining to health or care. Sixth, notwithstanding a few exceptions, the findings across the different nations were generally similar, suggesting their generality. Seventh and last, tweets pertaining to physiotherapists were most likely to refer to discourse pertaining to profession.

Conclusions

The findings indicate that health care professional associations do not use Twitter to disseminate cues that reinforce the importance of interprofessional care. Instead, they largely use this platform to emphasize what they individually deem to be important and advance the interests of their respective professions. Therefore, there is considerable opportunity for professional associations to assert how the profession they represent complements other health care professions and how the professionals they represent can enact interprofessional care for the benefit of patients and carers.
Referring Adolescent Primary Care Patients to Single-Session Interventions for Anxiety and Depression: Protocol for a Feasibility Study (Preprint)
Authors: Eyllon Mara , Dalal Michelle , Jans Laura , Sotomayor Ian , Peloquin Gabrielle , Yon James , Fritz Rochelle , Schleider Jessica
Published: January 2023

BACKGROUND

Despite the growing prevalence of depression and anxiety among adolescents, fewer than half access appropriate mental health care. Single-session interventions (SSIs) for depression and anxiety offered in primary care are a promising approach to bridging the treatment gap.

OBJECTIVE

We aimed to implement a clinical workflow for primary care and behavioral health providers to refer patients aged 13 to 17 years with mild to moderate depression and anxiety symptoms to Project YES (Youth Empowerment and Support), an open-access SSI platform, in a large group medical practice with an integrated behavioral health department.

METHODS

Pediatric primary care and integrated behavioral health providers will be educated on the benefits of Project YES for adolescent anxiety and depression and trained in a workflow integrated within the electronic health record system, Epic, to refer patients during well-child visits and pediatric behavioral health visits. Patients with mild to moderate internalizing symptoms based on the 17-item Pediatric Symptom Checklist or youth Pediatric Symptom Checklist will be invited to try an SSI through Project YES. We will examine provider uptake and perceptions of acceptability, feasibility, and appropriateness over time.

RESULTS

The rollout will take place between November 2022 and May 2023, when outcomes will be evaluated. Data analysis and manuscript writing are anticipated to be completed during the summer of 2023.

CONCLUSIONS

SSIs such as those available through Project YES have the potential to provide low-cost, evidence-based mental health treatment to adolescents with mild to moderate depression and anxiety. If deemed feasible and acceptable, providing SSIs in primary care settings could significantly improve access to mental health care without taxing pediatric primary care and behavioral health providers.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/45666
PROSPECTS FOR THE USE OF MICRORNAS IN MODERN METHODS OF DIAGNOSIS AND THERAPY
Authors:   Ural State Medical University, Kornilov Daniil O. , Tryapitsyn Michail A. ,   Ural State Medical University, Simarzina Veronika M. ,   Ural State Medical University, Koroleva Daria S. ,   Ural State Medical University, Grebnev Dmitriy Yu. ,   Ural State Medical University, Maklakova Irina Yu. ,   Ural State Medical University
Published: January 2023

MicroRNAs are evolutionarily conserved small non-coding RNA molecules 18–25 nucleotides long found in plants, animals, and some viruses that are involved in the transcriptional and post-transcriptional regulation of gene expression by RNA interference. Due to the unique biochemical and biophysical properties of the microRNA-associated catalytic protein complex RISC (RNA-inducible gene knockdown complex), these molecules carry out epigenetic regulation of the expression of a surprisingly large number of regulatory targets, including in humans. This article reviews the fundamentals and recent discoveries in the field of molecular mechanisms of microRNA functioning, the role of microRNA in the pathogenesis and course of socially significant diseases and diseases that occupy key positions in the structure of population mortality, namely, cardiovascular diseases, malignant neoplasms, human immunodeficiency virus (HIV). Also, this article presents some of the latest achievements in bioengineering and pharmacology in the development of new drugs based on RNA interference.
MORPHOFUNCTIONAL CHANGES IN GASTROINTESTINAL TRACT OF RATS DURING SULFUR MUSTARD INTOXICATION
Authors:   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation, Sidorov Sergey P. , Sergeev Anatoly A. ,   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Rus-sian Federation, Chepur Sergey V. ,   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Rus-sian Federation, Alekseeva Irina I. ,   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation, Volodymyrova Olga O. ,   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation, Zhakovko Ekaterina B. ,   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation, Kuzmin Andrey A. ,   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation, Shiryaeva Alyona I. ,   State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation, Bulka Kirill A. ,   Military Medical Academy of S. M. Kirova, Ministry of Defense of the Russian Federation
Published: January 2023

Sulfur mustard (SM) is a highly toxic blistering agent (vesicant) that has been widely used as a chemical weapon in wars and armed conflicts. Not only highly effective antidotes, but also tools for pathogenetic therapy of SM-induced lesions currently are not available, which necessitates further research in this field. Aim of the study: to examine the morphofunctional changes in gastrointestinal tract of rats during SM intoxication. Materials and methods. In experiments on rats during SM intoxication the severity of diarrhoea, propulsive activity and the specific mass of gastrointestinal tract were assessed, as well as performed a pathomorphological study of the small intestine. Results of the study. The obtained data indicate the development of the combined motor-evacuation, barrier, secretory-absorption and digestive intestinal dysfunction during SM intoxication. Conclusions. According to the authors, syndrome of intestinal insufficient is an important component of patho- and thanatogenesis of SM intoxication. Moreover, fluid sequestration and endocavitary pressure increase in gastrointestinal tract, which develop in consequence of its functional inability, should be considered as additional pathogenetic components of intoxication.
THE SIGNIFICANCE OF PERITONIAL FLUID IN THE GENESIS OF INFERTILITY IN WOMEN WITH OVARIAN ENDOMETRIOSIS
Authors:   Ural State Medical University, Mangileva Yana A. , Chizhova Anna V. ,   Ural State Medical University, Kudryavtseva Elena V. ,   Ural State Medical University, Islamidi Diana K. ,   Ural State Medical University, Geets Andrey V. ,   Ural State Medical University
Published: January 2023

Endometriosis is a common disease, reaching 10-20% among women of reproductive age. Early diagnosis of this disease (at the stage of formation of endometriotic heterotopias) is difficult due to the absence of typical changes in such non-invasive examination methods: MRI scan, ultrasound, CT scan. At the same time, the gold standard for diagnosis is an aggressive surgical approach — laparoscopy, which allows you to see the exact localization and extent of the lesion with endometriosis. Thereby, this requires the search for new methods of timely diagnosis, which would allow diagnosing genital endometriosis at an early stage. This article presents an overview of scientific articles that examine the role of biochemical parameters (various interleukins, tumor necrosis factor alpha, iron, chemokine) in peritoneal fluid. An increase or decrease in these markers makes it possible to reveal if a patient has external genital endometriosis and can be a factor in non-invasive confirmation of the disease.
Factors Affecting Trust and Interest in Transactions by Indonesian MSME Sellers in e-Commerce
Authors: Rizi Yongki Alfa , Dharma Fitra , Amelia Yunia , Prasetyo Tri Joko
Published: January 2023

Introduction/Main Objective: This study aims to examine the factors that influence the trust and interest in e-commerce transactions among MSME actors in Indonesia. Therefore, a study was conducted on the effect of these variables. Background of the problem: The transition of MSMEs in Indonesia to using e-commerce for carrying out their business transactions. Every year, there is an increase in the number of MSMEs converting from conventional to digital, as well as the government's contribution to assist in the transition. Novelty: The variable of interest in transacting through e-commerce is the basis for conventional businesses to switch to digital, but in other studies, no one has added a variable of trust as an intervening variable, and several other supporting variables for the interest in transacting via e-commerce. This study presents new research that provides a comprehensive view of the technology acceptance model (TAM) and how it relates to trust and interest in e-commerce transactions. Research Methods: This study uses a snowball sampling technique by employing a survey of the MSMEs in Indonesia with certain criteria. This study also uses structural equation modeling (SEM) based on partial least squares (PLS). Findings/Results: This study proves that all the variables of trust and interest in e-commerce transactions are supportive and significant, but there are two hypotheses that do not support them (H3 and H6). This shows that empirically MSMEs are not necessarily interested in using e-commerce for their business transactions. Conclusion: This study provides insight into the trust and interest in e-commerce transactions among MSME business actors. We suggest that the MSMEs should switch to using e-commerce for their transactions, to develop their businesses into digital ones.
The Effect of Tournament Horizon, Faultline and Group Performance Relationships under Decentralized System
Authors: Rohma Frida Fanani , Shofiyah Indah , Junaedi Abdus Salam
Published: January 2023

Introduction/Main Objectives: This research integrates the self-categorization and contagion theories to analyze faultlines due to a decentralization system. Besides, this research investigates the inducement of tournament incentives as a control mechanism to mitigate the harmful effects of a faultline on group performance. Background Problems: Fiscal decentralization has a crucial role as it stimulates economic growth, enhances the quality of decision-making and escalates performance. However, decentralization by one local government, which consists of various local government departments, may trigger a faultline. This research argues that patterned diversity convenes faultlines that split up a group into antagonistic sub-groups following the attributes affecting the aggregate group performance. Novelty: This research provides a new insight, in that decentralization appears to be a double-edged sword. It can elevate the quality of local decision-making, and trigger faultlines between local government departments at other times, affecting the local government’s aggregate performance. Research Methods: This research uses a laboratory experimental method with a 2×3 between-subjects factorial design. The research design uses the dyad analysis level. Finding/Results: The results found that the induction of a tournament scheme with the use of a cumulative ordinal scale for determining group performance encourages the social cognitive activation of individuals, thus encouraging cognitive orientation to optimize compensation and minimize categorization and antagonism. Conclusion: A tournament incentive scheme can be induced as a management control mechanism and to encourage the sub-groups to be winners. This resolution is expected to mitigate antagonistic behavior due to faultlines and enhance the optimization of aggregate performance
Selamatan Bayi Versi Orang Jawa: Kajian Linguistik Antropologis
Authors: Arif Budiman  , Ari Wulandari  , Noni Sukmawati
Published: January 2023

Selamatan bayi is a form of gratitude and a prayer request for congratulations for the baby. This study aims to describe the local wisdom of selamatan bayi using an anthropological linguistic approach to the contextual design of Javanese tradition. Data collection refers to the technique of recording, participatory observation, and interviews. The results of this study prove that selamatan bayi has a philosophical meaning based on Javanese cultureThere are seven kinds of selamatan bayi among the Javanese, namely (1) brokohan (birthday greetings), (2) sepasaran (5th birthday celebration), (3) selapanan (35-day baby celebration), (4) telonan (3 months birthday greetings), (5) pitonan (7 months of baby's birth), (6) setahunan (1 year of baby's birth), and (7) aqiqah (selamatan bayi for Javanese Muslims). The local wisdom of Javanese in selamatan bayi can be seen from five things, namely (1) the definition, (2) types, (3) ubarampe ‘equipment’, such as sega ingkung, sega gudangan, bubur abang putih, and so on; (4) the method of implementation, and (5) the development of the times. In every selamatan bayi contains the local wisdom of the Javanese to always maintain a balance between human relationships, the natural environment, and God.