bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of 3,4,5-Trihydroxybenzoic Acid Exploiting a Visible-Light-Driven Photoelectrochemical Platform: Application in Wine and Tea Samples
Authors: Lima Kayni , Fernandes Ridvan , dos Santos Clenilton , Damos Flavio , Luz Rita de Cássia
Published: November 2021

The present work is based on the development and application of a photoelectrochemical method for the amperometric determination of 3,4,5-trihydroxybenzoic acid in different samples. The method is based on the use of a photoelectrochemical platform based on a glass slide coated with fluorine-doped tin oxide, which has been modified with cadmium sulfide and poly(D-glucosamine) and subjected to a light-emitting diode (LED) lamp. The photoelectrochemical platform was sensitive to the increase of the concentration of the antioxidant 3,4,5-trihydroxybenzoic acid in the solution. Under the optimized experimental conditions, the photoelectrochemical method presented a linear response for a 3,4,5-trihydroxybenzoic acid concentration ranging from 0.2 up to 500 μmol L-1. The method was applied to 3,4,5-trihydroxybenzoic acid determination in samples of wines and teas with recoveries between 95.88 and 101.72%. The results obtained suggest that the developed platform is a promising tool for quantifying the 3,4,5-trihydroxybenzoic acid.
Integration of gender considerations into Tanzania's climate and water policies
Authors: Kironde Margaret Sima , Durodola Oludare Sunday , Kanyunge Claydon Mumba
Published: November 2021

Integrating gender considerations into national policies such as climate and water policies is a critical step toward achieving gender equality, resilient systems, sustainable water access and management of climate change. In Tanzania, just like in many developing countries, women play a vital role in water management and could be more vulnerable to climate change impacts than their male counterparts. While there are few attempts in existing literature to examine the integration of gender considerations into water and climate policies, analyzing policies' formulation process has not been given attention. Thus, this study analyzed the extent and effectiveness of gender integration in climate change and water sector policies in Tanzania. The study shows that there is a substantial acknowledgment of gender issues in the reviewed policy documents but there exist considerable gaps in terms of integrating gender issues in the documents and during formulation processes.
PECULIARITIES OF COMBAT SPORTS ATHLETES PSYCHOLOGICAL TRAINING
Authors: Uspuriene Aiste Barbora , Fokinas Ervinas
Published: November 2021

In the modern world of sports, exercise is not considered a key success factor. Sport is an environment in which individuals need to motivate themselves to achieve long-term goals. Athletes are constantly required to cope with the stress of training and competitive pressure and thus manage and regulate their emotions. Research aim – to analyze the literature and to reveal aspects of the effect of dance on girls’ motor abilities.
Análise inicial do uso e ocupação em trecho do riacho Ouro Preto – Olinda ⁄ PE - e sua influência para a potencialização de eventos de inundações
Authors: Costa Ana Márcia M. da
Published: November 2021

Este trabalho tem o objetivo de mostrar um estudo inicial sobre o uso e a ocupação do solo nas margens do riacho de Ouro Preto, bairro de Ouro Preto em Olinda – Pernambuco, que faz parte da Bacia Hidrográfica do Rio Paratibe, sendo um canal fluvial de 1ª ordem afluente do rio Fragoso. A área estudada apresenta uma configuração retilínea, com perfil longitudinal e pontos de maior profundidade, desse modo, o bairro sofre eventos de alagamentos decorrentes do período chuvoso. A intensificação de residências nas margens do canal é uma das causas para ocorrências de enchente no bairro, porém, isso tende a acontecer também por ausência de planejamento e gestão, voltadas para o controle dos dos espaços urbanos.
Presentación: Dossier Perspectivas actuales sobre Historia de la Educación en el Uruguay
Authors: Dogliotti Paola , Sosa Fernanda , Romano Antonio
Published: November 2021

El dossier que ponemos en sus manos, Perspectivas actuales sobre Historia de la Educación en el Uruguay, organizado en el marco de la Sociedad Uruguaya de Historia de la Educación (SUHE), pone a disposición una serie de artículos diversos sobre la historia de la educación que reúnen alguna de las siguientes características o enfoques y/o relaciones entre ellos: a. Diálogos transnacionales que intentan superar la mirada exclusivamente nacional y muestran los mecanismos de circulación de ideas, personas y/o objetos materiales, así como la actuación de instituciones y la configuración de redes de alcance transnacional. En este sentido, se pone el acento en escalas de análisis que no se reduzcan a Uruguay y que sean sensibles a la comprensión de dinámicas complejas de circulación, apropiación y reapropiación local de lo educativo; b. Giro afectivo y estética escolar. En alguna medida algunos de los artículos abordan el llamado “giro afectivo” en los estudios de historia de la educación y colocan como objetos de estudio las emociones, sentimientos, la estética, la educación del cuerpo y las sensibilidades en la educación; c. Estudios de género, sexualidades o interseccionales. En esta línea, se presentan artículos que en alguna medida abordan la historia de la educación con perspectiva de género, al pensar en la construcción de la diferencia sexual en el ámbito educativo. Por otra parte, abordan con diferentes modulaciones los vínculos entre sexualidad y educación, las masculinidades, feminidades y sexualidades en la educación, y la intersección de distintos marcadores de diferencia (género, nivel socio-económico, edad, raza/etnia, discapacidad, diversidad sexual, entre otros), entre los aspectos más relevantes.
Análise do perfil epidemiológico da Doença de Chagas no Brasil. Período entre 2001 e 2018
Authors: Lemos de Souza Macedo Thaís , Marques dos Santos Sara Cristine , Baptista dos Reis Rosa Renata , Moreira Vieira Pietra , Teixeira dos Santos Caio , Picone Borges de Aragão Ivana
Published: November 2021

A Doença de Chagas (DC) é considerada uma antropozoonose de ocorrência em região tropical, causada pelo protozoário flagelado Trypanosoma cruzi. Segundo a OMS, é uma doença negligenciada, onde existem cerca de 8 milhões de indivíduos infectados, sendo 28 mil casos/ano de registros de incidência e 12 mil óbitos/ano. No Brasil, foram registrados 1.156.821 no ano de 2010. O objetivo foi avaliar o perfil epidemiológico dos pacientes diagnosticados com DC aguda e a prevalência brasileira da doença nas últimas duas décadas. Estudo documental, retrospectivo, histórico, a partir da extração de dados do Departamento de Informática do Sistema Único de Saúde - DATASUS, oriundos do formulário “Sistema de Informação de Agravos de Notificação” (SINAN), entre o período de 2001 a 2018, dividido em dois segmentos: primeira década (2001-2010) e segunda década (2011-2018), possibilitando comparações entre os subperíodos temporais. Durante o período analisado, 5.184 notificações de DC aguda (288 pacientes/ano) foram registradas, sendo a região Norte a mais frequente do país. O sexo masculino, pardo e adultos jovens são os perfis mais prevalente entre os infectados. A variabilidade dos dados de prevalência da doença em demais estudos demonstra a limitação dos achados epidemiológicos e a presença de um silêncio epidemiológico. Acredita-se que esse dado seja muito maior na realidade da prática médica, devido aos casos de subnotificações. Dessa forma, se mostra necessária medidas preventivas e de monitorização epidemiológica dos casos confirmados e suspeitos, afim de que haja controle de possíveis focos vetoriais e outras formas de infecção.
Hipernatremia grave em recém-nascido resultante de falha no aleitamento materno: relato de caso
Authors: Hellen de Sousa Cavalcante Bárbara , Moreira Lara Thaís , Machado Gonçalves Arthur , Alberto Bhering Carlos , Terra de Oliveira Azevedo Christianne
Published: November 2021

A hipernatremia é um distúrbio hidroeletrolítico definido por concentração sérica de sódio superior a 145mEq/L, sendo considerada grave quando superior a 160mmol/L. É uma condição rara em recém-nascidos, causando sintomas predominantemente neurológicos, que pode ocorrer pela alta ingestão de sódio, perda excessiva de líquidos ou diminuição da ingestão de líquidos. A hipernatremia grave tem sido especialmente associada à dificuldade na amamentação e à perda de peso. Existem alguns fatores de risco associados como primiparidade, parto cesáreo, peso materno excessivo, problemas de amamentação, falta de experiência em amamentação e baixa escolaridade materna. O objetivo deste trabalho foi apresentar um relato de caso de hipernatremia resultante de uma amamentação inadequada. O caso relatou uma paciente de 23 dias de vida, apresentando quadro de desidratação grave e desnutrição, devido a dificuldades no aleitamento materno, sendo necessária a internação na Unidade de Terapia Intensiva (UTI). Após a realização de exames complementares, foi constatada hipernatremia (Na+ 182mmol/L) sendo tratada com infusão de soro fisiológico 0,9%. Paciente ainda evoluiu com convulsão, sendo tratada com fenobarbital. Após 36 dias de tratamento, neonato recebeu alta hospitalar. Portanto, conclui-se que a hipernatremia grave associada à dificuldade na amamentação pode ser uma condição evitada se o aleitamento materno for bem-sucedido, condição essa que seria possível com estratégias preventivas pelo sistema de saúde para gestantes e puérperas, como o acompanhamento mãe/neonato na primeira semana de vida.
The Use of Textiles in the Wound Healing: A Review
Authors: Oliveira Janaína Ribeiro , Guimarães Victor Hugo Dantas , Pereira Ulisses Alves , Oliveira Fernando Ribeiro , Santos Sérgio Henrique Sousa
Published: November 2021

:

The present article reviews the effects of the textile in the wound healing process, as well
as the availability of these products in the market. A brief description of applications is given based on
the literature obtained from searching the scientific databases, besides the data obtained from secondary
sources, like books and congress proceedings. The historical context of the textiles used in
wounds, their general characteristics, particularities in the healing process, and incorporation of new
technologies are discussed. It was evidenced that the textiles and associated technologies might influence
directly or indirectly the stimulation of collagen, cell migration, angiogenesis, and reduction of
pro-inflammatory factors and fibroblasts. However, the mechanisms by which the textiles act in the
healing process are not well established in the literature. The interaction among textile engineering,
biotechnology, medicine, and pharmacology is essential for the improvement and development of new
products with better efficiency and accessibility.
In vitro Aggregation Ability of Five Commercially Available Aβ42 peptide
Authors: Lv Zhaoji , Du Xi , Chen Zhongsheng , Liu Fengjuan , Zhang Rong , Ma Li , Ye Shengliang , Jiang Peng , Wang Zongkui , Cao Haijun , Li Changqing
Published: November 2021

Background:

As the most basic material, synthetic human Amyloid-β (1-42) (Aβ42) pep-
tides from different manufacturers have been widely used. Their aggregation ability is vital to the
reliability, repeatability and comparability of studies on Aβ42 physiology and pathology. However,
it has not been evaluated and compared.

Objectives:

To analyze the consistency of the aggregation ability of 5 commercially available Aβ42
peptides.

Methods:

5 Aβ42 peptides represented as A, B, C, D and E were pretreated by HFIP. The pretreated
Aβ42 peptides were dissolved in Thioflavin T (ThT) solution, and their aggregation kinetics was
monitored for 30 h with the aggregation kinetics test. Meanwhile, the pretreated peptides were ag-
gregated in phosphate buffered saline. After aggregated for 12 h, they were detected by methods of
ThT fluorescence, far-UV circular dichroism (CD), SDS-PAGE, western blot, and transmission
electron microscopy (TEM), respectively. After aggregation for 8 h and 12 h, their cytotoxicity to
SH-SY5Y cells was further evaluated using Cell Counting Kit-8.

Results:

For aggregation kinetics, peptides A, C and E remained low level curves, while peptides
B and D presented typical sigmoidal kinetics curves. In CD measurement, the aggregates of pep-
tides B and D showed relatively high negative CD peaks with the height of -8.09 mdeg and -14.37
mdeg, while the height of peptides A, C and E was -1.04, -3.55, and -3.88. In ThT assay, relative
fluorescence intensity of the aggregates of peptides B and D were 7.79 and 8.82, higher than 1.19,
1.71, and 2.70 of peptide A, C and E, respectively. In SDS-PAGE, all aggregates contained
monomers and eleven polymers. Moreover, peptide B-E presented a trapezoidal distribution from
dimers to trimers, and peptide A aggregated to dimers. By western blot, the bands of monomers re-
mained in all aggregates. Furthermore, peptides B and D aggregated to dimers and trimers, pep-
tides A and C only aggregated to dimers, and peptide E showed a strong band of trimers. By TEM,
protofibrils were observed only in peptide B, while substantial spherical aggregates were formed in
other peptides. Additionally, peptides B, D and E exhibited higher cytotoxicity after being aggregat-
ed for 8 h, whereas peptides A, B and D presented relatively high cytotoxicity after 12-hour aggre-
gation.

Conclusion:

Commercially available Aβ42 peptides showed obvious differences in aggregation abil-
ity, which should arouse enough attention in the field of basic study related to Aβ42. The aggrega-
tion ability evaluation with the various assay methods has some discrepancies, and it is highly ur-
gent to establish a reasonable and uniform measurement strategy.
Evaluation of Anticancer and Epidermal Growth Factor Receptor Inhibition Activity by Benzochromeno Pyrimidin Derivatives in Three Human Cancer Cell Lines
Authors: Mohammadian Razieh , Ardestani Sussan Kabudanian , Safavi Maliheh
Published: November 2021

Background:

Cancer therapy is one of the most important challenges that human beings
are facing. The abnormal activity of epidermal growth factor receptor tyrosine kinase (EGFR1) in
tumors has been reported in many studies. Tyrosine kinase inhibitors are now commercially available
for the treatment of a variety of cancers. Based on our previous studies, we assumed that a hybrid of
aminopyrimidine derivatives as EGFR inhibitors and benzocheromen derivatives as cytotoxic agents
can induce apoptosis in EGFR positive cancer cells. In the present study, the cytotoxic effect, ability
of EGFR inhibition and apoptosis induction of some synthetic benzochromene pyrimidine derivatives
were investigated on MDA-MB231, SKBR3 and PC3 cell lines.

Methods:

The EGFR inhibition activity was determined using cell-based EGFR ELISA kit. Cell
viability was determined by MTT assay in 2D and 3D cultures. The apoptosis was confirmed through
different methods such as fluorescent staining, annexin V– propidium iodide double staining, DNALadder
assay, caspase-3 colorimetric assay, and nitric oxide assay.

Results:

The results of the MTT assay showed that derivatives with different substituents exhibited
differential cytotoxicity in three cancer cell lines, although in MDA-MB231 the cytotoxicity effect of
compounds is more obvious than the other cell lines. Production of nitric oxide, caspase-3 activity
and DNA-fragmentation was significant in MDA-MB231 and PC3 cells. SKBR3 cells, despite having
the lowest apoptosis among these three cell lines, showed a significant EGFR inhibition in the
ELISA assay.

Conclusion:

In this research, we proved that hybrids of benzochromene and amino pyrimidine could
be effective on growth inhibition of cancer cell lines and may be used as a drug candidate for cancer
therapy in the future.
Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder
in Children: A Randomized Controlled Trial
Authors: Gamal Fatma , El Agami Osama , Salamah Abeer
Published: November 2021

Background:

Attention Deficit Hyperactivity Disorder is a common child neurobehavioral
disorder whose pathogenesis is not completely understood. However, some evidence indicates a
crucial link between this disorder and the degree of oxidative stress. Coenzyme Q10 (ubiquinol) is
an antioxidant that may play a significant role in the treatment of Attention Deficit Hyperactivity
Disorder.

Objective:

To assess the safety and efficacy of coenzyme Q10 as an add-on drug treatment for attention
deficit hyperactivity disorder.

Method:

Sixty children, aged 6-16 years, with attention deficit hyperactivity disorder, non-responders
to atomoxetine treatment for 6 months, were included in this double-blind, randomized, and
controlled study. Group 1 received atomoxetine plus coenzyme Q10, and group 2 received atomoxetine
plus placebo for 6 months. Follow-up by CONNERS parent rating scale questionnaire
(CPRS-48) was performed before and after 1, 3, and 6 months of treatment, and any drug-related
side effects were reported.

Results:

The addition of coenzyme Q10 to atomoxetine in group 1 improved symptoms in a shorter
time with minimal adverse effects. Group 1 showed improvement of about 33.87% in CPRS-48 total
score versus 18.24% in group 2. There was a statistically significant decrease in CPRS-48 total
score and its three subscales (learning problems, impulsive hyperactive subscale, and 10-items hyperactivity
index) in group 1 versus group 2 after six months of treatment (p-value <0.001).

Conclusion:

Coenzyme Q10 has an important role as an add-on drug treatment for attention deficit
hyperactivity disorder by improving symptoms, particularly hyperactivity, and in minimizing atomoxetine
adverse effects.

Trial Registration:

The study was registered at clinicalTrials.gov (https://clinicaltrials.gov/). Registration
identification number: NCT04216186.
A Systematic Review of Pain Assessment in Mechanically Ventilated Patients
Authors: Salamat Elaheh , Sharifi Farshad , Hasanloei Mohammad Amin Valizade , Bahramnezhad Fatemeh
Published: November 2021

Introduction:

Pain self-report is the gold standard of pain assessment. Mechanically ventilated patients cannot self-report the pain due to the presence of a tracheal tube and changes in the level of consciousness caused by sedation, exposing them to the risk of inadequate pain management that leads to psychological and physiological consequences. This study aimed to present a review of the published evidence and studies concerning the scales used in pain assessment in mechanically ventilated patients according to their psychometric characteristics and application in the nursing practice.

Methods:

We conducted a systematic review following PRISMA guidelines. National and international journals in such databases as Science Direct, PubMed, EMBASE, Pro Quest Central, Web of Science, SID, and Magiran were searched using Persian and English keywords, and retrieved articles were included in this review based on the inclusion and exclusion criteria.

Results:

22 articles were included in this review based on the inclusion and exclusion criteria. According to the research objectives, findings were extracted from selected articles and reviewed in two sections: 1] validity and reliability, and 2] clinical application.

Conclusion:

Scales of CPOT and BPS are superior to NVPS, and a combination of BPS and CPOT improves the pain detection accuracy, and vital symptoms should be used cautiously for pain assessment along with objective measures due to poor evidence. Moreover, rapid and effective pain relief plays an important role in the improvement of psychological and physiological consequences.
Beier Sentence Completion Test Profiles of Adolescents and Emerging
Adults With Internalizing and Externalizing Disorders
Authors: Koç Gencay , Çolak Burçin , Tatlı Safiye Zeynep , İlhan Rifat Serav , Oncu Bedriye
Published: November 2021

Background:

Understanding adolescents' and emerging adults' psychiatric
complaints and their relations with psychiatric disorders can be challenging. Beier Sentence
Completion Test (BSCT), as a projective test, can be promising in this respect. However,
relations between BSCT profiles and adolescent psychopathology are not well known.

Aim:

This study aimed to examine and compare BSCT profiles of adolescents and emerging
adults with internalizing and externalizing disorders. As well as that, the relation of BSCT
profiles with depression and anxiety scores was investigated.

Objective:

To achieve this aim, we retrospectively collected the hospital records of 300
adolescents and emerging adults (aged. 14-21) admitted to an Adolescent Psychiatry
Outpatient Unit.

Method:

The psychiatric diagnosis of the patients was classified as Internalizing (n = 100)
and Externalizing (n = 100) disorder groups; the control group (n = 100) consisted of
adolescents and young adults without any psychiatric diagnosis. BSCT, the Beck
Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were administered on the
first admission to all cases before psychiatric evaluation and treatment. BSCT total
subfactor (positive, negative, neutral, and non-response) statement scores were compared
between groups, and their correlations with BDI and BAI were investigated. Besides,
multivariate logistic regression analyses were conducted for estimating any diagnostic group
differences, as well as bivariate logistic regression analyses for estimating BDI and BAI cutoff
scores with models that included BSCT total subfactor statement scores.

Results:

It was revealed that lower positive and non-response statements were crucial for
distinguishing externalizing and internalizing disorders and that positive and negative
statements were correlated with depression and anxiety scores.In the multivariate regression
model, these correlations were predictive only for the relationship between internalizing
disorders group and low positive statement scores, not higher negative statement scores that
can be associated with lack of positive emotional processing in this group. Also, nonresponse
statement scores were found to be predictive for externalizing disorder groups.
Similarly, BDI cut-off scores were predicted with low positive statement scores.

Conclusion:

BSCT profiles can be promising for understanding adolescents and emerging
adults with internalizing and externalizing disorders. Lack of positive attributions to the self
and other domains of life can be important for differentiating adolescent psychopathology.
The identity of Tai-Yai ethnic to promote community tourism in Mae Hong Son Province, Thailand
Authors: Sasong Sanya
Published: November 2021

This study of the identity of Tai-Yai ethnic to promote community tourism in Mae Hong Son province is a participatory action research that aimed to find a format for building a learning center for Tai-Yai identity and to establish a network of Tai-Yai identity conservation groups that is linked to community tourism in Mae Hong Son Province. This study focused on the way of life and identity of Tai-Yai people in five districts in Mae Hong Son province include Pai, Pang Mapha, Muang, Khun Yuam, and Mae La Noi. The results of the research were as follows: the Tai-Yai communities maintain their way of life, the concept of belief in the supernatural, and Buddhism beliefs, pass on their identity to the younger generation, and transfer their identity to the general public. The Tai-Yai community of Pambok village has the potential to build a learning center for the Tai-Yai identity at the community level by linking with the Tai-Yai Education Center, Mae Hong Son province which is a “FICES” model (Sustainable Education Community Identity of Tai-Yai  Faith).
Infancias queer/cuir: Nuevas miradas sobre la infancia desde el sur
Authors: Josiowicz Alejandra , Francica Cynthia , Punte María José
Published: November 2021

Introducción al dossier.
Riqueza de las plantas vasculares del bosque altoandino de Bijagual, Colombia
Authors: Gil Leguizamón Pablo Andrés , Morales-Puentes María Eugenia , Carrillo-Fajardo Merly Yenedith
Published: November 2021

Antecedentes y Objetivos: El bosque altoandino en Colombia corresponde a una formación vegetal, localizada entre 2400-3200(-3500) m s.n.m. Se caracteriza por la presencia de especies arbóreas con distribución restringida que determinan su fisionomía y composición. No obstante, dichas especies han sido afectadas por la actividad agrícola que ha generado pérdida de conectividad y de riqueza. Esta investigación registra la riqueza, composición y datos de distribución de flora vascular en el bosque altoandino del Macizo de Bijagual, Boyacá, Colombia. Métodos: Se realizaron muestreos en 27 transectos. Los ejemplares fueron organizados bajo el sistema de clasificación APG IV, curados y depositados en el herbario UPTC (Universidad Pedagógica y Tecnológica de Colombia). Se obtuvo el número de especies, listado de taxa, distribución para Colombia y categorías de conservación según la UICN. Resultados: Se registraron 327 especies, distribuidas en 151 géneros y 69 familias; 187 especies (56%) son nativas de la región andina, 51 (15%) endémicas de los Andes y 24 (7%) endémicas de la cordillera Oriental colombiana. Schefflera bejucosa es un nuevo registro de distribución para Boyacá. Greigia stenolepis, Hieronyma rufa, Puya goudotiana y Tillandsia pallescens presentan la categoría Casi Amenazado (NT), Plutarchia guascensis, Quercus humboldtii y Symplocos venulosa, Vulnerable (VU); Diplostephium oblongifolium y Dunalia trianaei En Peligro (EN). Conclusiones: Bijagual es un corredor biológico con gran potencial de biodiversidad comparado con otras áreas altoandinas en Colombia. La riqueza es influenciada por otras localidades cercanas al Macizo (Tota y Mampacha), además de una posible distribución estocástica y heterogénea entre unidades de muestreo. Miconia, Pentacalia, Epidendrum, Elaphoglossum, Tillandsia y algunos otros géneros son ricos en especies. Clusia alata, Weinmannia balbisiana, Weinmannia rollottii, Ternstroemia cf. camelliifolia y Brunellia comocladifolia definen la fisionomia arbórea y arbustiva de Bijagual.
Hubungan Pemberian Informasi Obat Oral Dengan Kepuasan Pasien di Ruang Rawat Inap Bakung RSUD Panembahan Senopati Bantul Yogyakarta
Authors: Rimba Putri Imram Radne , . Zulpahiyana , Adekayanti Lis
Published: November 2021

Informasi dan pelayanan merupakan masalah utama yang paling banyak ditemui,dimana informasi dan pelayanan yang diberikan oleh pihak rumah sakit dianggapmasih belum cukup, bahkan mengecewakan pasien. berdasarkan data dari Yayasan Lembaga Konsumen Indonesia (YLKI), 2011 menunjukan bahwa masih kurangnya tingkat kepuasan pasien di Indonesia terhadap pelayanan rumah sakit termasuk pelayanan perawat. Penelitian ini bertujuan untuk mengetahui hubungan pemberian informasi obat oral dengan kepuasan pasien di ruang rawat inap bakung RSUD Panembahan Senopati Bantul Yogyakarta dan jenis penelitian yang digunakan adalah kuantitatif dengan pendekatan waktu cross sectional, jumlah sampel 109 responden dengan teknik sampling secara accidental sampling dan dianalisis menggunakan uji statistik kendal tau. Hasil dari penelitian ini menunjukan bahwa sebagian besar responden menyatakan bahwa pemberian informasi obat oral yang disampaikan perawat dalam kategori baik yaitu 95 (87,2%) responden dengan tingkat kepuasan sebagian besar menyatakan sangat puas yaitu sebanyak 56 (51,4%). Hasil analisis data tersebut menunjukan bahwa ada hubungan yang signifikan antara pemberian informasi obat oral dengan kepuasan pasien di ruang rawat inap bakung RSUD Panembahan Senopati Bantul Yogyakarta.

Kata Kunci: Pemberian Informasi Obat Oral, Kepuasan Pasien.
Prevalence of Multimorbidity of Chronic Noncommunicable Diseases in Brazil: Population-Based Study
Authors: Shi Xin , Lima Simone Maria da Silva , Mota Caroline Maria de Miranda , Lu Ying , Stafford Randall S , Pereira Corintho Viana
Published: November 2021

Background

Multimorbidity is the co-occurrence of two or more chronic diseases.

Objective

This study, based on self-reported medical diagnosis, aims to investigate the dynamic distribution of multimorbidity across sociodemographic levels and its impacts on health-related issues over 15 years in Brazil using national data.

Methods

Data were analyzed using descriptive statistics, hypothesis tests, and logistic regression. The study sample comprised 679,572 adults (18-59 years of age) and 115,699 elderly people (≥60 years of age) from the two latest cross-sectional, multiple-cohort, national-based studies: the National Sample Household Survey (PNAD) of 1998, 2003, and 2008, and the Brazilian National Health Survey (PNS) of 2013.

Results

Overall, the risk of multimorbidity in adults was 1.7 times higher in women (odds ratio [OR] 1.73, 95% CI 1.67-1.79) and 1.3 times higher among people without education (OR 1.34, 95% CI 1.28-1.41). Multiple chronic diseases considerably increased with age in Brazil, and people between 50 and 59 years old were about 12 times more likely to have multimorbidity than adults between 18 and 29 years of age (OR 11.89, 95% CI 11.27-12.55). Seniors with multimorbidity had more than twice the likelihood of receiving health assistance in community services or clinics (OR 2.16, 95% CI 2.02-2.31) and of being hospitalized (OR 2.37, 95% CI 2.21-2.56). The subjective well-being of adults with multimorbidity was often worse than people without multiple chronic diseases (OR=12.85, 95% CI: 12.07-13.68). These patterns were similar across all 4 cohorts analyzed and were relatively stable over 15 years.

Conclusions

Our study shows little variation in the prevalence of the multimorbidity of chronic diseases in Brazil over time, but there are differences in the prevalence of multimorbidity across different social groups. It is hoped that the analysis of multimorbidity from the two latest Brazil national surveys will support policy making on epidemic prevention and management.
A Phenotyping Algorithm to Identify People With HIV in Electronic Health Record Data (HIV-Phen): Development and Evaluation Study (Preprint)
Authors: May Sarah B , Giordano Thomas P , Gottlieb Assaf
Published: November 2021

BACKGROUND

Identification of people with HIV from electronic health record (EHR) data is an essential first step in the study of important HIV outcomes, such as risk assessment. This task has been historically performed via manual chart review, but the increased availability of large clinical data sets has led to the emergence of phenotyping algorithms to automate this process. Existing algorithms for identifying people with HIV rely on a combination of International Classification of Disease codes and laboratory tests or closely mimic clinical testing guidelines for HIV diagnosis. However, we found that existing algorithms in the literature missed a significant proportion of people with HIV in our data.

OBJECTIVE

The aim of this study is to develop and evaluate HIV-Phen, an updated criteria-based HIV phenotyping algorithm.

METHODS

We developed an algorithm using HIV-specific laboratory tests and medications and compared it with previously published algorithms in national and local data sets to identify cohorts of people with HIV. Cohort demographics were compared with those reported in the national and local surveillance data. Chart reviews were performed on a subsample of patients from the local database to calculate the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the algorithm.

RESULTS

Our new algorithm identified substantially more people with HIV in both national (up to an 85.75% increase) and local (up to an 83.20% increase) EHR databases than the previously published algorithms. The demographic characteristics of people with HIV identified using our algorithm were similar to those reported in national and local HIV surveillance data. Our algorithm demonstrated improved sensitivity over existing algorithms (98% vs 56%-92%) while maintaining a similar overall accuracy (96% vs 80%-96%).

CONCLUSIONS

We developed and evaluated an updated criteria-based phenotyping algorithm for identifying people with HIV in EHR data that demonstrates improved sensitivity over existing algorithms.
Prevalence of Multimorbidity of Chronic Noncommunicable Diseases in Brazil: Population-Based Study (Preprint)
Authors: Shi Xin , Lima Simone Maria da Silva , Mota Caroline Maria de Miranda , Lu Ying , Stafford Randall S , Pereira Corintho Viana
Published: November 2021

BACKGROUND

Multimorbidity is the co-occurrence of two or more chronic diseases.

OBJECTIVE

This study, based on self-reported medical diagnosis, aims to investigate the dynamic distribution of multimorbidity across sociodemographic levels and its impacts on health-related issues over 15 years in Brazil using national data.

METHODS

Data were analyzed using descriptive statistics, hypothesis tests, and logistic regression. The study sample comprised 679,572 adults (18-59 years of age) and 115,699 elderly people (≥60 years of age) from the two latest cross-sectional, multiple-cohort, national-based studies: the National Sample Household Survey (PNAD) of 1998, 2003, and 2008, and the Brazilian National Health Survey (PNS) of 2013.

RESULTS

Overall, the risk of multimorbidity in adults was 1.7 times higher in women (odds ratio [OR] 1.73, 95% CI 1.67-1.79) and 1.3 times higher among people without education (OR 1.34, 95% CI 1.28-1.41). Multiple chronic diseases considerably increased with age in Brazil, and people between 50 and 59 years old were about 12 times more likely to have multimorbidity than adults between 18 and 29 years of age (OR 11.89, 95% CI 11.27-12.55). Seniors with multimorbidity had more than twice the likelihood of receiving health assistance in community services or clinics (OR 2.16, 95% CI 2.02-2.31) and of being hospitalized (OR 2.37, 95% CI 2.21-2.56). The subjective well-being of adults with multimorbidity was often worse than people without multiple chronic diseases (OR=12.85, 95% CI: 12.07-13.68). These patterns were similar across all 4 cohorts analyzed and were relatively stable over 15 years.

CONCLUSIONS

Our study shows little variation in the prevalence of the multimorbidity of chronic diseases in Brazil over time, but there are differences in the prevalence of multimorbidity across different social groups. It is hoped that the analysis of multimorbidity from the two latest Brazil national surveys will support policy making on epidemic prevention and management.
Defining Telehealth for Research, Implementation, and Equity (Preprint)
Authors: Roy Joy , Levy Deborah R , Senathirajah Yalini
Published: November 2021

UNSTRUCTURED

When the COVID-19 pandemic spurred a disruption in health care delivery, the role of telehealth shifted from an option to a near necessity to maintain access when in-person care was deemed too risky. Each state and many organizations developed temporary telehealth policies for the COVID-19 emergency, each policy with its own definitions, coverage, government cases, and regulations. As pandemic-era policies are now being replaced with more permanent guidelines, we are presented with an opportunity to reevaluate how telehealth is integrated into routine health care delivery. We believe that the timing and nature of the sequential steps for redefining telehealth are critical and that it is important to develop a clear and agreed-on definition of telehealth and its components at this time. We further suggest a necessary preliminary step is to support clear communication and interoperability throughout the development of this definition. Precise and standardized definitions could create an unambiguous environment for clinical care for both patients and providers while enabling researchers to have more precise control over their investigations of telehealth. A consensus when defining telehealth and its derivatives at this critical stage could create a consistent expectation of care for all patients and those who set the standards of care, as it has for other clinical scenarios with clear guidelines.
Challenges in Participant Engagement and Retention Using Mobile Health Apps: Literature Review (Preprint)
Authors: Amagai Saki , Pila Sarah , Kaat Aaron J , Nowinski Cindy J , Gershon Richard C
Published: November 2021

BACKGROUND

Mobile health (mHealth) apps are revolutionizing the way clinicians and researchers monitor and manage the health of their participants. However, many studies using mHealth apps are hampered by substantial participant dropout or attrition, which may impact the representativeness of the sample and the effectiveness of the study. Therefore, it is imperative for researchers to understand what makes participants stay with mHealth apps or studies using mHealth apps.

OBJECTIVE

This study aimed to review the current peer-reviewed research literature to identify the notable factors and strategies used in adult participant engagement and retention.

METHODS

We conducted a systematic search of PubMed, MEDLINE, and PsycINFO databases for mHealth studies that evaluated and assessed issues or strategies to improve the engagement and retention of adults from 2015 to 2020. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Notable themes were identified and narratively compared among different studies. A binomial regression model was generated to examine the factors affecting retention.

RESULTS

Of the 389 identified studies, 62 (15.9%) were included in this review. Overall, most studies were partially successful in maintaining participant engagement. Factors related to particular elements of the app (eg, feedback, appropriate reminders, and in-app support from peers or coaches) and research strategies (eg, compensation and niche samples) that promote retention were identified. Factors that obstructed retention were also identified (eg, lack of support features, technical difficulties, and usefulness of the app). The regression model results showed that a participant is more likely to drop out than to be retained.

CONCLUSIONS

Retaining participants is an omnipresent challenge in mHealth studies. The insights from this review can help inform future studies about the factors and strategies to improve participant retention.
Correction: Examining the Interaction Between Medical Information Seeking Online and Understanding: Exploratory Study (Preprint)
Authors: Kobayashi Rei , Ishizaki Masato
Published: November 2021

UNSTRUCTURED

REMOVE
Implicación paterna post divorcio: una revisión sistemática
Authors: Lizarazu Lucía , Cracco Cecilia
Published: November 2021

El divorcio o la separación conyugal implica cambios en la estructura de las familias y en los arreglos de convivencia que han estado marcados por sesgos de género. Reconociendo la importancia de la implicación del padre en el desarrollo de los hijos y el factor protector que supone en estos escenarios, se realizó una revisión sistemática de la literatura con el objetivo de conocer las variables que se vinculan a la implicación de padres no residentes. Aplicando criterios de búsqueda y selección específicos, se analizaron 14 artículos de investigación. Los resultados reconocen la incidencia de variables sociodemográficas, de residencia, vinculadas a los arreglos familiares y al tipo de vínculo entre los excónyuges. Se discuten las características de los estudios incluidos y las limitaciones de la revisión realizada y se aportan ideas para la investigación del fenómeno vincular en estudio. Se concluye resaltando la necesidad de que las intervenciones psicosociales y/o decisiones judiciales referidas al divorcio consideren los factores que podrían favorecer la implicación del padre, en beneficio de todos los miembros del sistema familiar.
Quantum thermo-dynamical construction for driven open quantum systems
Authors: Dann Roie , Kosloff Ronnie
Published: November 2021

Quantum dynamics of driven open systems should be compatible with both quantum mechanic and thermodynamic principles. By formulating the thermodynamic principles in terms of a set of postulates we obtain a thermodynamically consistent master equation. Following an axiomatic approach, we base the analysis on an autonomous description, incorporating the drive as a large transient control quantum system. In the appropriate physical limit, we derive the semi-classical description, where the control is incorporated as a time-dependent term in the system Hamiltonian. The transition to the semi-classical description reflects the conservation of global coherence and highlights the crucial role of coherence in the initial control state. We demonstrate the theory by analyzing a qubit controlled by a single bosonic mode in a coherent state.
Hacia una comprensión de la evolución de los estudios de seguridad y su impacto en Colombia
Authors:   Policía Nacional de Colombia, Rodríguez Samora Diego Stetid
Published: November 2021

Este capítulo tiene como objetivo realizar una revisión sobre la evolución del concepto de seguridad a través del tiempo, las Relaciones Internacionales como disciplina, y el impacto que ha tenido en la concepción de seguridad pública en Colombia y en instituciones como la Policía Nacional. Se aborda la corriente realista y liberal con sus respectivas vertientes, seguido de la corriente de seguridad humana con sus enfoques críticos. La metodología usada para el desarrollo de la investigación fue de carácter cualitativo y con un alcance descriptivo para el caso de estudio, el cual fue guiado por el análisis de fuentes primarias y secundarias, creando una visión deductiva. Se concluye que la adopción de diversas formas de concebir la seguridad, alimentan las percepciones de seguridad ciudadana en el país y, así mismo, los campos de acción y estrategias de instituciones encargadas como la Policía Nacional de Colombia.
Gobierno local y gestión territorial: la prevención situacional del delito en la ciudad de Cali
Authors: Fernández Patiño Andrés Felipe
Published: November 2021

Para establecer las implicaciones prácticas de la gestión territorial de la seguridad, intervención del territorio y de la participación ciudadana en Cali durante el 2019, se realizó un estudio descriptivo-observacional con base en la triangulación del gobierno local, Policía Nacional y comunidad enmarcado en la prevención situacional del deli-to. Los resultados reflejan la capacidad de articulación de la Secretaría de Seguridad y Justicia, los logros desarrollados en ese año por los coordinadores de comuna y las limitantes tanto de articulación como de gestión de la mano del área de Prevención y Educación Ciudadana (PRECI) de la Policía Nacional. Es la primera vez en Colombia que una teoría de la criminología ambiental es puesta en marcha como parte de del programa Plan Integral de Seguridad Ciudadana y Convivencia (PISCC) y no como una acción aislada al interior de la prevención y control del delito de las diferentes entidades territoriales.
Why more competent adolescents advance or regress after assymetrical peer interaction: Studying dialogue characteristics that make a difference
Authors: Stepanovic-Ilic Ivana , Baucal Aleksandar
Published: November 2021

This study explores differences between more and less competent peers in joint problem-solving dialogues, related to opposite interaction outcomes of more competent students (progression/regression). Ten asymmetrical peer dyads were selected from 47 dyads participating in the previous study: five in which more competent (MC) student progressed the most, and five in which MC students regressed the most after a post-test. Ten dialogue characteristics were established in 50 conversations of these dyads. Cluster analysis revealed two dialogue types associated with different interaction outcomes of MC students. In the first one, MC students justified correct answers but behaved inconsistently with their higher competences. The second cluster characterizes domination-submissiveness pattern and MC students? unwillingness to justify opinion. All regressing MC students participated in the first dialogue type and 56% of progressing MC students in the second. Qualitative analysis of the conversations typical for extracted clusters implies that although ready to provide arguments to their peers when they can, regressing MC students exhibit uncertainty, thereby losing from interaction. Progressing MC students seem to protect themselves against possible interaction disturbances by dominant attitude and withdrawal from communication.
Mot ei framtid for utmarksbeite – om beiting, sjølvkjensle og forståing mellom folk
Authors: Flø Bjørn Egil
Published: November 2021

The once-proud graziers have begun to have doubts. They have begun to doubt whether everything they used to believe, everything that gave meaning to what they have been doing, still makes sense.

This essay takes the reader home to the graziers and out into the Norwegian countryside: the mountains, forests and deep fertile valleys, the terrain the Norwegians call outfields (utmark). Based on conversations with graziers in different parts of Norway, this essay discusses the future of grazing in the outfields against the backdrop of the big, as well as the small, political and social issues that both the graziers and we as a society are facing.

For the graziers are struggling with many questions today. Is it no longer ecologically sustainable to use the outfields resources for food production? Shouldn’t the outfields be a resource for the production of food and fibre anymore? Is there no place for grazing animals in the Norwegian mountains in the future? Grazing farmers are currently asking themselves these questions and more. They feel degraded and exposed in the public debate, and the feeling tears at their self-image and makes every day grey; it becomes increasingly difficult to find motivation for each day that passes.

But what can be done to reverse this trend? What can the grazing farmers do themselves, and what do we others need to do for them, politically as well as socially? This chapter discusses the emergence of a new concept of outfields and how it has affected grazing in the outfields. The essay raises a number of important questions that we as a society need to address in the debate about the future role of traditional upland grazing areas in our landscape.
Menneske og dyr i grenseland – om rettar, rettferd og rett ferd i utmarka
Authors: Flemsæter Frode , Brown Katrina M.
Published: November 2021

In this chapter, we examine how people and animals have co-created borders, land rights and practices in outfields (utmark) in Norway. Further, we examine how this plays a part when change and increasing diversity is managed. We do this by examining conflicts arising between farmers, landowners and reindeer herders in Norway, resulting from policy imperatives towards agricultural diversification. We find that different stakeholders with rights that are relevant in this context may have different capacities to respond when valuations of outfield resources change, and that the human-animal relations in reindeer herding are having a particular impact on these capacities. We argue that the current regulatory system negotiating the interests of different stakeholders with rights struggles to comprehend or deal with issues of animal agency and mobility in reindeer-herding practices. We propose that Haraway’s concept of response-ability can be useful to help make more-than-human agency more visible, and therefore better accounted for, in the unsettling and resettling of property relations in the Norwegian outfields. This allows us to understand more precisely how human-animal relations, in our case relations between reindeer and reindeer herders, affect the responses available to the various stakeholders when land and land-use rights in the outfields are negotiated.