bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Pakar Mendiagnosa Penyakit Keputihan Pada Wanita Dengan Metode Teorema Bayes
Authors: Simanjuntak Christina , Riandari Fristi
Published: June 2021

Leucorrhoea is a discharge other than blood from the vaginal canal, if abnormal vaginal discharge is left untreated, as a result the infection can spread, enter the uterus, fallopian tubes, and can infect the ovaries. The application of an expert system in the health sector will greatly assist in survival someone. Expert systems can help diagnose a type of disease based on their own symptoms quickly and precisely. An expert system that is designed as a tool to diagnose the type of leucorrhoea, especially in women who experience vaginal discharge, but often they feel able to recognize themselves that they are suffering from vaginal discharge without feeling the need to go to a doctor for a more detailed examination, and only treat themselves with medication. Free-sale vaginal discharge medication. This expert system will display a selection of symptoms that can be selected by the user, then get the final result with the Bayes theorem method by providing a diagnosis result in the form of a probability value for the emergence of each type of disease and solution. Expert system applications are built on a web basis using HTML, PHP, CSS using the mysql database.
Authors: Suryaman Ratih , Girsang Elpinaria , Mulyani Siti
Published: June 2021

Introduction Breastfeeding is the process of providing food to babies by using breast milk directly from the mother's breast, breast milk is a food that can protect babies from diarrhea and other infectious diseases. Breast milk has important benefits for the growth of babies and mothers. During the Covid19 pandemic, it caused a crisis in mothers in breastfeeding for fear of transmitting the virus to their children through breast milk. Factors that influence mothers in offering breastmilk are due to the lack of information received by mothers about breastfeeding during the pandemic. This study aims to determine the relationship between knowledge and mothers in offering breast milk during the Covid19 pandemic. Method: This study uses quantitative research, using descriptive analytical methods with a Cross Sectional approach.Using the HRS-A Knowledge Questionnaire and Instruments instrument to calculate. The sampling technique was total sampling, with a sample of 42 breastfeeding mothers. The analysis technique used univariate and bivariate analysis with the Spearman statistical test. Results: The results showed that from 42 respondents there were 14 (33.3%) respondents with less knowledge with moderate estimates. Where to get a P value of 0.027, which means that there is a relationship between knowledge and mothers in offering breast milk to babies during the Covid pandemic, with an OR value of 0.232, where the p value ≤0.05, which means that Ha is accepted and Ho is rejected. Discussion: There is a relationship between knowledge and the conclusions of mothers in offering breast milk during the Covid19 pandemic
Authors: Yuswatiningsih Endang , Hani R Iva Milia
Published: June 2021

Introduction: Social isolation is a condition where individuals have difficulty building relationships with other people. One of the efforts to deal with individuals with social isolation problems is by conducting therapeutic communication. This study aims to analyze the relationship between therapeutic communication and social interaction in social isolation patients at Rejoso Public Health Center, Nganjuk Regency, East Java. Methods: This type of research is correlation analytic with a cross-sectional design. The population in this study were all patients with social isolation at Rejoso Public Health Center with a sample size of 25 respondents using simple random sampling. Data collection using questionnaires and observation sheets. Analyzing using Spearman rho's statistical test with alpha 0.05. Results: showed that therapeutic communication in most categories was sufficient for as many as 18 respondents (72%) and social interaction in most categories was sufficient for as many as 20 respondents (80%). The results of the Spearman rho statistical test showed that the value of p = 0.003 <alpha 0.05 so that H1 was accepted. Discussion: Therapeutic communication is an interpersonal relationship between the nurse as a caregiver and the client so that the nurse and the client get a learning experience together to improve the emotional experience felt by the client so that a therapeutic relationship is created.
Visibilidad de la co-innovación en sitios Web de empresas en América Latina
Authors: Ocampo-Villegas María Cristina , Suárez-Sucre Elías David
Published: June 2021

La innovación colaborativa abierta, co-innovación o co-creación es una nueva tendencia en investigación y desarrollo que está siendo adoptada por diferentes organizaciones en todo el mundo. El presente trabajo busca dar respuesta a ¿Cómo las grandes empresas de América Latina están utilizando sus sitios Web para visibilizar los procesos de innovación colaborativa abierta e interactuar con sus públicos de interés? La investigación es un acercamiento al conocimiento de la innovación empresarial en la región, en particular en las grandes empresas. Se revisaron en total 120 home page de las empresas más grandes de México, Costa Rica, Colombia, Ecuador, Perú, Chile, Argentina y Brasil, excluyendo las multinacionales cuyo capital de origen fuera externo al país analizado. De este total, se evidenció el registro de procesos de co-innovación en 43 sitios Web, lo que equivale al 36% de las empresas analizadas. El análisis de dicha información arrojó que prevalece la co-innovación abierta con colaboradores integrados, principalmente con clientes y proveedores.
Relación entre la tecnología y la comercialización en la PyME ubicada en Zacatecas
Authors: Correa García Luis Ángel
Published: June 2021

El objetivo de este estudio empírico es analizar desde el enfoque teórico de recursos y capacidades la relación entre la tecnología y la comercialización en la PyME ubicada en Zacatecas, México. La metodología empleada fue el análisis factorial exploratorio de máxima verosimilitud de ecuaciones estructurales; la variable “tecnología” se midió a través de una escala construida con base en la revisión de literatura compuesta por 4 preguntas, la variable “comercialización” se midió por tres ítems. Los resultados muestran que la tecnología impacta de manera significativa en la comercialización. Se concluye que las empresas deben invertir en infraestructura y mejorar su posición tecnológica, así como el nivel de implementación de tecnología; respecto a la comercialización la utilización de redes sociales es relevante y las empresas deben de poseer una marca, nombre, logotipo y etiqueta para insertarse en los mercados locales e internacionales. Ambas variables repercuten en la competitividad empresarial.
Os fatores condicionantes para o empreendedorismo feminino local
Authors: Da Silva Santos Rayla , Silva Renan
Published: June 2021

O objetivo deste artigo consiste em explorar os perfis e fatores condicionantes que impulsionam o empreendedorismo feminino na cidade de São José do Belmonte-PE. Para tal, a metodologia adotada classifica a pesquisa como qualitativa de cunho exploratória e descritiva. Por fim, os resultados foram obtidos com êxito, pois delimitamos as características sociodemográficas que descrevem o grupo de empreendedoras locais, bem como assimilamos os propósitos e aspirações que conduziram a escolha dessa atividade laboral.
Evolution of Approaches to Risk Management in Organizations
Authors:   National Pharmaceutical University, Zoidze D. R. , Gubarev O. O. ,   Kharkiv State Academy of Culture
Published: June 2021

The article is aimed at studying the evolution of approaches to risk management in organizations. As result of the carried out study, three existing approaches were identified: the «Three Lines of Protection» model (2013), the «Three Lines» model (2020), and the «Dynamic Risk Management» model (2020). It is proposed to consider the «Three Lines of Protection» model as a transition from non-systemic risk management in organizations to a structured vision of this process with a clear definition of the responsibilities of key participants. The article explains the advantages and disadvantages of this approach. Its advantages include simplicity and clarity in use in practice. Among the shortcomings of the model are the following: an overly structured approach to risk management in organizations; too cautious attitude to possible risks; dubious versatility of the model; imperfection of its structure. Three directions for possible improvement of the model are defined. It is identified that in 2020 there was an updated approach to risk management in organizations – the «Three Lines» model. A comparison of the «Three Lines of Protection» model with the «Three Lines» model was carried out. The main advantages of the new approach are determined. The emergence of an alternative vision of the process of risk management and control in organizations against the background of new social challenges – the «Dynamic risk management» is researched. The advantages of this approach include its priority areas in risk management in organizations, i.e.: risk management taking into account their consequences, risk management based on actions, risk management with an orientation towards digital technologies. The differences between traditional models and the newest approach are specified. It is determined that each of the three principles of the latest approach improves the quality of risk management in organizations as participants in the survey conducted by Gartner company. Purpose of further research in this direction be the institutional registration of coordinated interaction between the two directions of the modern model of risk management and control of the risks.
Formation of Personnel Potential of an Enterprise Through the Development of Creative Abilities of the Staff
Authors:   Odesa National Economic University, Tanasiuk I. M. , Kirsho S. M. ,   Odesa National Economic University
Published: June 2021

The article is aimed at substantiating the theoretical and methodological principles of formation of personnel potential of the enterprise and elaborating practical recommendations for the development of creative abilities of staff. On the basis of systematization and generalization of existing scientific achievements, the concept of personnel potential, features of its formation in modern conditions are considered. The factors that influence the formation of personnel potential of enterprises in Ukraine are analyzed. The problems of formation of personnel potential of companies capable of creative response to changes in the external environment, analyzing large amounts of information, determining the impact and interaction of various factors and anticipating future events in the market are researched. Positive examples of procedures for the formation of personnel potential from the experience of modern enterprises are presented. As a result of the study, it was determined the need to create partnerships between the State and enterprises, so that conditions for the development of creativity can be formed, and it is proclaimed that the development of creative abilities of the enterprise’s staff allows to increase the innovativeness of a company and the country in general. The article defines that the necessity to meet the education of personnel with modern trends requires the organization of lifelong learning, which involves combining and updating the necessary knowledge, skills and abilities in order to adapt to modern processes for the sake of continuous professional development. The methods for development of creativity of the enterprise’s staff aimed at overcoming thinking stereotypes that interfere with the development of creativity in modern conditions are proposed. A special place is given to the problem of maintaining the performance of the enterprise’s staff in the context of the COVID-19 pandemic.
Evolution of the Bankruptcy Legislation in Ukraine
Authors:   Kharkiv National University of Construction Engineering and Architecture, Belikova T. V. , Vorobiova A. А. ,   Kharkiv National University of Construction Engineering and Architecture
Published: June 2021

The article is aimed at defining the main changes in the bankruptcy legislation in Ukraine, as well as the stages of evolution of the bankruptcy institute. The dynamics of bankruptcies of enterprises is considered, stages of evolution of the bankruptcy institute in Ukraine are systematized. Despite the small number of real bankruptcies so far, this problem in the context of quarantine measures is very significant and requires sufficient attention, since mass bankruptcies have an immoderate impact on the country’s economy. As a result of the study, the main changes in the legislation of Ukraine on bankruptcy procedures are determined. These are the criteria for opening a debtor’s bankruptcy procedure; approach to establishing and paying monetary remuneration of the insolvency receiver; term of sanitation; deadline for filing an application by the creditor for debt repayment after publication about opening a bankruptcy procedure; norm on limiting the participation of interested parties in voting at a meeting of creditors when approving a sanitation plan; term for filing an application by the creditor for the repayment of debt after publication about opening a bankruptcy procedure, as well as the possibility of bankruptcy of an individual – not a business entity. The new Code of Ukraine on Bankruptcy Procedures has enacted a set of innovations designed to improve the State regulation of the process of rehabilitation of potentially capable enterprises through their sanitation or reorganization, as well as to simplify the liquidation procedure for those enterprises whose opportunities have already been exhausted, and establishing their activities is impossible. The positive consequences of the introduction of the Code should be a reduction in the terms of application of property management procedures and sanitation measures while increasing the efficiency of these measures.
Applied Aspects of Industrial Production Research in Ukraine
Authors:   Lviv Polytechnic National University, Feshchur R. V. , Kolinko N. O. ,   Lviv Polytechnic National University, Shyshkovskyi S. V. ,   Lviv Polytechnic National University, Skvortsov D. I. ,   Lviv Polytechnic National University
Published: June 2021

Industry is one of the important sectors of the economy of any country in the world. At the same time, statistics show that the industrial complexes of many countries are developing unevenly, with periodic changes in the structure and volume of production under the influence of many internal and external factors. Ukraine's industrial complex is also undergoing spatial and structural distortions, but these trends do not always correspond to those formed in the world's leading countries in the direction and pace of change, although today the industrial complex of Ukraine is the most important structural part of Ukraine's economy, a third of fixed assets and more than 30% of the employed population. As one of the largest spheres of social production in the country, industrial production determines the level of its socio-economic development, the specialization of the economy and the extent of participation in the territorial division of labor. Properly chosen strategy for the development of industrial production, the appropriate volume and structure of production, a reasonable volume of sales allows all participants in production to achieve their financial goals. This is due to the importance of studying the activities of industrial enterprises. The article constructs nonlinear models of multiple regression, which describe the main trends in industrial production, the effect of external and internal factors on the economic performance of industry in general and industrial enterprises in the western region of Ukraine. It is established that innovative transformations in industrial production have led to the renewal of fixed assets and have had a positive effect on the dynamics of economic results. At the same time, this process was accompanied by a reduction in the number of people employed in industry. It is revealed that the influential factors of the external environment include economic conditions of management, and among the factors of the internal environment – the management of innovation and innovation activity of economic entities. It is recommended to expand the set of tools at the expense of distribution-lag, autoregressive, simulative and other econometric models to describe the relationship between the economic performance of enterprises and factor characteristics.
The Influence of Work Competency and Motivation on Employee Performance
Authors: Wijayanto Benedictus Kristo , Riani Asri Laksmi
Published: June 2021

Employee performance has a contribution to the development of a company. The personal performance of an employee can influence by competency and work motivation factors. This research was arranged based on theoretical analysis as well as empirical studies. The research aims to define a structured thinking concept about the relationship between competency variables, work motivation, and employee performance. Worker performance is the result of efforts achieved by a person or group who work in a company. Then competence leads to the employee’s deep and inherent personality. Work motivation is the driving force that makes an employee use his/her abilities to complete the works. Further research can examine conceptual frameworks in business, manufacturing, and service organizations.
Postmodern Children and The Cement Garden of Ian McEwan
Authors: Vajda Réka
Published: June 2021

Postmodern childhood narratives often explore disturbing themes, break social conventions and taboos. In order to comment on this kind of representation, this study will introduce Ian McEwan’s controversial novel The Cement Garden (1978), the story of four children who, in the middle of a particularly hot summer, find themselves orphaned. The novel narrated by fourteen-year-old Jack explores such themes as sexuality, incest, death, the struggles of coming of age, isolation, gender roles and parent-child relationships.
Retos y oportunidades en la enseñanza de las matemáticas en el bachillerato
Authors: Macías Hernández Efraín
Published: June 2021

Enseñar implica tomar en consideración tanto a los actores del proceso educativo como el contexto cultural y social en el que está inserto este proceso; dicho contexto se determina o delinea en un currículum o plan de estudios del cual se desprenden los diferentes programas de materia. Enseñar matemáticas, específicamente a nivel medio superior, implica también reconocer aspectos, tales como los conocimientos con los que egresan los estudiantes de educación básica y su actitud ante esta asignatura. El propósito del presente artículo es propiciar una reflexión en torno al quehacer del docente de matemáticas en este nivel educativo y las estrategias que se pueden incorporar en el aula para enfrentar el reto de enseñar cualquier materia de esta área del conocimiento.
El Departamento de Formación y Actualización Académica durante el periodo 2017–2019
Authors: Departamento de Formación y Actualización Académica DEFAA
Published: June 2021

En este artículo se presentan los principales resultados de las actividades realizadas en el Departamento de Formación y Actualización Académica durante el periodo 2017–2019.
La transformación del proceso de enseñanza-aprendizaje del taller de diseño interdisciplinar: de lo presencial al trabajo colaborativo en línea. Nuevos retos académicos
Authors: Molina Ayala María Elena , Loredo Zamarrón Jaime Javier
Published: June 2021

El presente trabajo pretende compartir la experiencia de vida de estudiantes y profesores de la Facultad del Hábitat de la Universidad Autónoma de San Luis Potosí (UASLP), surgida a partir de la transformación en los procesos de enseñanza aprendizaje, que, de manera repentina y forzados por una pandemia, pasaron de lo presencial a lo virtual en un taller de diseño que se lleva a cabo en el noveno semestre de las seis licenciaturas impartidas en la Facultad, el cual fundamenta su esencia en el trabajo colaborativo e interdisciplinar con responsabilidad social; y lo desarrolla en comunidades vulnerables, basando su proceso de diseño en un diagnóstico obtenido a partir de la convivencia y la relación entre la comunidad universitaria y la del lugar objeto del estudio.
Enhanced Direct Power Control Strategy of a DFIG-Based Wind Energy Conversion System Operating Under Random Conditions
Authors: Sahri Younes , Tamalouzt Salah , Belaid Lalouni Sofia
Published: June 2021

The main objective of this paper is the performances analysis of an Enhanced Direct Power Control (EDPC), applied to Doubly Fed Induction Generator (DFIG) driven by variable speed Wind Turbine (WT). This control strategy uses hysteresis regulators and switching table for active and reactive powers control. These latter are estimated using rotor currents and grid voltages instead of a traditional measurement of stator currents. In addition, the EDPC switching table is based on the position of the rotor flux instead of the stator flux in order to have better regulation accuracy because the rotor voltage vector directly influences the rotor flux and has a proportional relationship with the active and reactive powers. All the operating modes (sub-synchronous, super-synchronous, synchronous and over-speed) of the variable speed WT-DFIG system and the possibility of local reactive power compensation are reported and discussed in this paper. Depending on the operating zone of the WT, Maximum Power Point Tracking (MPPT) technique and pitch angle control are considered to optimize the wind energy efficiency. The validation of the proposed EDPC strategy has been performed through simulation tests under MATALB/Simulink, the obtained results show robustness and good performances with low THD of the generated currents.
Nanotechnology to deliver cannabinoids in dermatology
Authors: Adusumilli Nagasai C. , Hazuka Elizabeth L. , Friedman Adam J.
Published: June 2021

Cannabis-derived compounds and therapies targeting the endocannabinoid system (ECS) are demonstrating benefit for clinical conditions beyond current indications. As our understanding of the ECS in the skin continues to develop, cannabinoids are rapidly showing promise for treating cutaneous pathology. However, unstable pharmacokinetics, bioavailability and skin permeability have been significant constraints on their utility in dermatology. As cannabinoids shift from commercial herbal preparations to prescription drugs, nanosized drug delivery strategies can tackle these physiochemical limitations and allow well-designed clinical trials to establish safety and efficacy. This review summarizes the latest evidence for cannabinoids for skin disease, details the challenges of formulating cannabinoids, and highlights how the success of nanomedicine across therapeutic fields can translate to novel nanocannabinoid therapeutics in dermatology.
Is Agricultural Credit Programme Effective in Boro Cultivation? Evidence from State-owned Bank of Mymensingh District
Authors: Deb L , Sarkar MAR , Siddique MAB , Begum R
Published: June 2021

High input-intensive Boro rice cultivation needs substantial agricultural credit for the resource-poor Bangladeshi farmers. An investigation was conducted at Fulbaria upazila of Mymensingh district to assess loan attainment cost from Bangladesh Krishi Bank (BKB) and its utilization pattern; evaluate the effects of credit on Boro cultivation, and identify the major drivers of the agricultural credit programme. For the study, 140 farmers were divided into two groups: those who took a loan from BKB and those who did not. Results revealed that the borrowers had to pay Tk 10.23 for getting a hundred taka loan from BKB most of which was an unofficial cost. More than half of the obtained loan was used for Boro cultivation whereas 21% was used for family consumption and the rest (25%) was used for other purposes such as reimbursement of the previous loan from formal and informal sources, wedding and other income-generating activities including petty business. BKB credit borrowers obtained more benefits through Boro cultivation than non-borrowers. The major strengths of the BKB’s agricultural credit programme were well-established infrastructure, experienced manpower, country-wide network, and lower interest rate. Whereas complex and lengthy institutional procedures, the inevitability of collateral and poor institutional capacity were being revealed as the weaknesses of the programme. Prevalence of brokers or corrupt officials and political influence were identified as the major constraints for the loan acquirement. More advanced research is recommended, with an emphasis on agricultural credit programmes, to ensure their effectiveness.

Bangladesh Rice J. 24 (1): 85-95, 2020
Data integrity aspects of reporting results for the specification parameter related and degradation products in chromatography data system
Authors: Dobrkovikj Shotarovska Milena , Babunovska Hristina , Dimitrovska Aneta
Published: June 2021

The most convenient way to implement the requirements of Good Manufacturing Practice and the data integrity principles in a control analytical laboratory is to automate the entire analytical process as fully as possible. Obtaining a final reliable result from an analytical testing as part of a formal analysis is one segment of the process of providing Good Manufacturing Practice. In this paper, we describe the steps by which one control analytical laboratory can formalize and automate the entire process of obtaining and issuing analytical results through creating Report Template for calculation of the specification parameter Related and Degradation Products as part of a Chromatography Data System. The process is described in several steps from designing and structuring of the report so that it would respond best to the end-user's requirements, through identifying eventual oversights in the creation phase, to the final phase of validation, which once again confirms the integrity of its content and justifies its use for formal analysis.
The use of such validated Report Templates for calculation and reporting of the results from analytical testing eliminates the human error factor and increases the confidence in the issued results as well as in the entire laboratory’s workflow. Their application facilitate compliance with regulations and minimizes manual input of data which in turn meets one of the most crucial requirements of Good Manufacturing Practice.

Keywords: data integrity, chromatography data system, report template, related and degradation products
Possíveis tratamentos farmacológicos em fase de estudos para pacientes sintomáticos de COVID-19:Uma revisão integrativa
Authors: Silva Danielle Guimarães , Bartaquini Renan Tripode , Pedrosa Beatriz Moraes , Ribeiro Carolina Heitmann Mares Azevedo , Prete Ana Cristina Lo
Published: June 2021

Objetivo: Realizar uma revisão integrativa sobre os possíveis tratamentos farmacológicos estudados atualmente como estratégias terapêuticas para pacientes COVID-19 positivos. Métodos: Foi realizada uma revisão integrativa de estudos da base de dados Medical Literature Analysis and Retrieval System, no sistema de busca PUBMED, na qual foram selecionados 58 artigos abordando 9 classes de fármacos. Resultados: A distribuição dos 58 artigos incluídos na revisão foi categorizada por fármaco abordado. Foram considerados tratamentos com melhoras significativas os que observaram redução de carga viral, redução do tempo de internação ou melhora clínica estatisticamente relevantes de acordo com os critérios de cada estudo. Conclusão: Com a urgência da produção rápida de resultados, foi observado que há uma grande dificuldade de produção de ensaios clínicos cego, duplo cego, fazendo com que a comunidade científica se restrinja principalmente a estudos retrospectivos e observacionais, que não são tão eficientes quanto os citados anteriormente. Com base na observação dos estudos, ainda não há um tratamento eficaz para a COVID-19, sendo crucial a aplicação de medidas preventivas, a fim de evitar o impacto da doença na população.
The impact of job satisfaction on employee performance through organizational commitment as intervening variables: A survey on employees of Mitra Swalayan Kartasura
Authors: Suprayitno . , Lamidi . , Qomariah Jeane Rosalia
Published: June 2021

Mitra Swalayan Kartasura is a private company engaged in the retail sector to fulfill basic needs. This  objective  is  to  address  the impact  of  satisfaction  on commitment to organizational commitment, to respond to the significance of the impact of the organization on employee performance, to indicate the significance of the impact of employee performance on satisfaction and whether the organization can mediate employee job satisfaction. This type of research uses the census method for Mitra Swalayan Kartasura employees. This research uses qualitative data and quantitative data. Meanwhile, the data source uses primary data and secondary data. The population is all employees of Mitra Swalayan Kartasura who assess 85 employees. The sample in this study were 85 employees with the census method. The data analysis technique used multiple regression test, t test, F test, indirect effect test, path analysis and coefficient of determination. The results of the study indicate that job satisfaction can have a positive and significant  effect  on  organizational  commitment,  there  is  no  positive  and significant influence between organizational commitment on employee performance, job satisfaction can have a positive and significant effect on employee performance and in this study it cannot prove that organizational commitment. mediate job satisfaction on employee performance.
Incidência de aneurismas de artéria coronária na Síndrome Inflamatória Multissistêmica Pediátrica por COVID-19: Uma revisão sistemática
Authors: Fonseca Gustavo Soares Gomes Barros , Assunção Izabely Lima , Mendes Ana Karoline de Almeida , Barbosa Lara Matias , Gomes Myrella de Jesus Cruz , Pinheiro Paula Rafaela Costa , Vale Maria Fernanda Almeida do , Ferreira Yakyra Henrique de Sousa , Dias Lucas da Silva , Sousa Andrews Matheus Reis , Paranhos Hyasmin Bomfim , Nogueira Maria Eduarda Martins , Santos Hosana da Luz Bezerra Leite dos , Normando Lara Vasconcelos , Silva Valéria Marques da , Gomes Cálide Soares
Published: June 2021

Aneurismas de artéria coronária são dilatações em um segmento arterial. Tais alterações já decorriam de certas patologias conhecidas. No entanto, com a chegada da pandemia causada pela COVID-19, constatou-se um aumento nos casos de crianças com aneurismas coronários quando associados à Síndrome Inflamatória Multissistêmica Pediátrica pelo SARS-CoV-2, denominada PIMS-TS. O presente estudo busca analisar a incidência de aneurismas de artéria coronária na Síndrome Inflamatória Multissistêmica Pediátrica por COVID-19. Foram analisados 22 artigos originais relacionados ao tema, entre 2020 e 2021, em inglês e português, através das bases de dados do PubMed, LILACS, Google Scholar e SciELO. Os critérios de exclusão utilizados foram: Livros, documentos de projetos de dissertação, resumos em eventos, editoriais, revisões de literatura, relatos de caso isolados, artigos que não cumpriam os critérios de inclusão e artigos duplicados. Diante dos estudos analisados, conclui-se que a incidência de aneurismas de artéria coronária ocorre por meio da PIMS-TS. A menor taxa de incidência encontrada foi de 2,3%, a maior, de 79,92%, com média geral de ± 17,34%.
Hambúrguer adicionado de pulmão bovino: elaboração, composição e avaliação sensorial
Authors: Silva Cristiane Nunes da , Carmo Juliana Rodrigues do , Oliveira Geane da Silva , Abrahão Sheila Andrade
Published: June 2021

O pulmão bovino, considerado como víscera, muitas vezes é descartado de forma inadequada no meio ambiente. No entanto, este órgão destaca-se por apresentar elevados teores de ferro e proteínas com alto valor biológico. Diante disso, o objetivo do presente estudo foi elaborar um produto enriquecido com ferro heme biodisponível. Foram elaboradas formulações de hambúrguer com diferentes quantidades de pulmão bovino. Nestes produtos foram determinados a composição centesimal e o teor de ferro. As amostras foram avaliadas sensorialmente por testes de aceitação e de intenção de compra do produto. Os dados obtidos foram analisados por meio da análise de variância e comparados pelo teste de Tukey (p<0,05). Os hambúrgueres produzidos com diferentes quantidades de pulmão apresentaram majoritariamente em sua composição água (67,9-68,16%), proteínas (18,16-19,05%) e lipídios (8,09-8,31%). O teor de ferro heme biodisponível variou entre 9,23 e 14,03 mg/100g entre as amostras, sendo aproximadamente três vezes maior na amostra com 100 g de pulmão, em relação à amostra controle. Os hambúrgueres formulados com adição de pulmão bovino foram aceitos pelos provadores (IA>70%) e apresentaram altas porcentagens de intenção de compra (>82%). O produto pode ser considerado uma alternativa promissora para a ingestão de ferro e de aminoácidos essenciais, que podem auxiliar no combate à anemia e reduzir as consequências causadas por esta carência no corpo humano, como déficit no desenvolvimento motor e cognitivo.
Human impact on symbioses between aquatic organisms and microbes
Authors: Stock W , Callens M , Houwenhuyse S , Schols R , Goel N , Coone M , Theys C , Delnat V , Boudry A , Eckert EM , Laspoumaderes C , Grossart HP , De Meester L , Stoks R , Sabbe K , Decaestecker E
Published: June 2021

Aquatic organisms rely on microbial symbionts for coping with various challenges they encounter during stress and for defending themselves against predators, pathogens and parasites. Microbial symbionts are also often indispensable for the host’s development or life cycle completion. Many aquatic ecosystems are currently under pressure due to diverse human activities that have a profound impact on ecosystem functioning. These human activities are also expected to alter interactions between aquatic hosts and their associated microbes. This can directly impact the host’s health and—given the importance and widespread occurrence of microbial symbiosis in aquatic systems—the ecosystem at large. In this review, we provide an overview of the importance of microbial symbionts for aquatic organisms, and we consider how the beneficial services provided by microbial symbionts can be affected by human activities. The scarcity of available studies that assess the functional consequences of human impacts on aquatic microbial symbioses shows that our knowledge on this topic is currently limited, making it difficult to draw general conclusions and predict future changes in microbial symbiont-host relationships in a changing world. To address this important knowledge gap, we provide an overview of approaches that can be used to assess the impact of human disturbances on the functioning of aquatic microbial symbioses.
Cohort structure and individual resource specialization in loggerhead turtles, long-lived marine species with ontogenetic migrations
Authors: Muñoz CC , Saito T , Vermeiren P
Published: June 2021

Cohort structure and degree of individual resource specialization affect individual- and population-level fitness and ecosystem interactions. These 2 characteristics are difficult to establish for long-lived marine species such as sea turtles. Both characteristics were approached by applying a novel Broken-Stick analysis of Stable isotope Time series (BS-SiTs) framework to longitudinal data series derived from metabolically inert carapace scute tissue of 13 loggerhead turtles Caretta caretta near the coast of Kochi prefecture, Japan. During the subadult stage, δ15N signatures decreased 1.29‰ per 50 µm scute slice away from values associated with neritic habitats and a diet of benthic invertebrates. Following a breakpoint, δ15N signatures stabilized in the range of 10-15‰, corresponding with planktonic feeding adults with an oceanic foraging strategy in the North Pacific. Ontogenetic shifts in δ15N occurred at different chronological points for each individual, implying the presence of a diverse cohort structure within the local coastal population. During the adult stage, within-individual variation in δ15N was <6.1% of the total δ15N variation among sampled individuals. To offer effective protection, management actions should account for this potentially high individual resource specialization at the scale of local coastal populations. Nesting numbers of loggerhead turtles in Japan have been declining since the 1990s. The BS-SiTs framework provides ecological baseline information on ontogenetic shifts in resource use of individuals suitable to support management plans. Specifically, when applied across multiple individuals, the BS-SiTs framework offers a low-cost, non-invasive solution to monitor and compare trends in cohort structure among local coastal populations.
Impact of ocean carbonation on long-term regulation of light harvesting in eelgrass Zostera marina
Authors: Celebi-Ergin B , Zimmerman RC , Hill VJ
Published: June 2021

Seagrasses account for approximately 10% of the total carbon stored in the ocean, although photosynthesis of seagrasses is carbon-limited at present oceanic pH levels. Therefore, increasing atmospheric CO2 concentration, which results in ocean acidification/carbonation, is predicted to have a positive impact on seagrass productivity. Previous studies have confirmed the positive influence of increasing CO2 on photosynthesis and survival of the temperate eelgrass Zostera marina, but the acclimation of photoprotective mechanisms in this context has not been characterized. We aimed to quantify the long-term impacts of ocean acidification on photochemical control mechanisms that promote photosynthesis while simultaneously protecting eelgrass from photodamage. Eelgrass were grown in controlled outdoor aquaria at different aqueous CO2 concentrations ranging from ~50 to ~2100 µM from May 2013 to October 2014 and examined for differences in leaf optical properties. Even with daily and seasonal variations of temperature and light, CO2 enrichment consistently increased plant size, leaf thickness and chlorophyll use efficiency, and decreased pigment content and the package effect while maintaining similar light-harvesting efficiency. These acclimation responses suggest that a common photosynthetic sensory function, such as redox regulation, can be manipulated by CO2 availability, as well as light, and may serve to optimize photosynthetic carbon gain by seagrasses into the Anthropocene.
An Empirically-Based Conditional Learning Progression for Climate Change
Authors:   University of Maryland, College Park, Breslyn Wayne
Published: June 2021

Climate change encompasses a broad and complex set of concepts that is often challenging for students and educators. Using a learning progressions conceptual framework, we develop a description of student learning of climate change based on our research findings and an extensive review of the science education research literature. In this exploratory study we present findings from written assessments (N=294) and in-depth interviews (n=27) with middle school students in which we examine their understanding of the role of human activity, mechanism, impacts, and adaptation and mitigation of climate change. Findings, along with evidence from the science education research literature, are synthesized into a first step empirically supported learning progression describing a path from an initial to a developed understanding of climate change. The empirically supported learning progression contributes to the climate change education research literature and provides the education community with a robust description of how student understanding of climate change advances over time.
Transcription Factors in the Development and Pro-Allergic Function of Mast Cells
Authors: Srivastava Mansi , Kaplan Mark H.
Published: June 2021

Mast cells (MCs) are innate immune cells of hematopoietic origin localized in the mucosal tissues of the body and are broadly implicated in the pathogenesis of allergic inflammation. Transcription factors have a pivotal role in the development and differentiation of mast cells in response to various microenvironmental signals encountered in the resident tissues. Understanding the regulation of mast cells by transcription factors is therefore vital for mechanistic insights into allergic diseases. In this review we summarize advances in defining the transcription factors that impact the development of mast cells throughout the body and in specific tissues, and factors that are involved in responding to the extracellular milieu. We will further describe the complex networks of transcription factors that impact mast cell physiology and expansion during allergic inflammation and functions from degranulation to cytokine secretion. As our understanding of the heterogeneity of mast cells becomes more detailed, the contribution of specific transcription factors in mast cell-dependent functions will potentially offer new pathways for therapeutic targeting.
Green Milk From Contented Cows: Is It Possible?
Authors: Webster John
Published: June 2021

The dairy industry is open to criticism on several fronts: obesity and ill health among the affluent, high demand for crops that could be consumed more sustainably and more equitably by ourselves, environmental damage and climate change, and abuse of animal welfare through production diseases and denial of normal patterns of behaviour. All these criticisms are valid. It is necessary therefore to examine in depth the nature and extent of specific problems to see which, if any, are inevitable, which can be mitigated and which can be avoided altogether. Dairy cattle, like all ruminants, can be sustained wholly, or in part on complementary feeds; grasses and crop residues that cannot be fed directly to humans. Fed appropriate diets dairy cows can produce more energy and protein for human consumption than they consume. The greenhouse gas, methane is an inevitable consequence of rumen fermentation. High yielding cows in confinement produce less methane per litre of milk. There is some scope for reducing methane production through manipulation of rumen fermentation but the impact is likely to be small. The most serious welfare abuses can be linked to genetic and management strategies designed to maximise milk yield from individual cows. These manifest in production diseases and metabolic exhaustion, both leading to premature culling. All these problems; too much milk, too much food waste, too much methane, too many stressed cows, are matters of degree. The poison is in the dose. Thus, solutions will not come from radical advances in biological science but public and political exercises in moderation.
Prediction of Sensitivity and Efficacy of Clinical Chemotherapy Using Larval Zebrafish Patient-Derived Xenografts of Gastric Cancer
Authors: Zhai Jing , Wu Jiaqi , Wang Yaohui , Fan Ruoyue , Xie Guiping , Wu Fangfang , He Yani , Qian Sitong , Tan Aimin , Yao Xuequan , He Mingfang , Shen Lizong
Published: June 2021

Background

Perioperative chemotherapy has been accepted as one of the most common approaches for locally advanced gastric cancer. However, the efficacy of chemotherapy varies among patients, and there is no effective method to predict the chemotherapy efficacy currently. We previously established the first larval zebrafish patient-derived xenografts (zPDXs) of gastric cancer as a platform for the translational research and personalized treatment. The objective of this study was to investigate the feasibility of screening individualized chemotherapeutics using the zPDXs.

Methods

We further optimized this zPDXs platform including administration route, drug dosing, and rhythm to develop a stable and reliable protocol for chemotherapeutics screening. Using the novel platform, we investigated the chemosensitivity of 5-fluorouracil, cisplatin, docetaxel, and doxorubicin for gastric cancer patients.

Results

We showed that the engrafted zebrafish retained the original prominent cell components of the corresponding human tumor tissues, and we successfully obtained the results of chemosensitivity of 5-fluorouracil, cisplatin, docetaxel, and doxorubicin for 28 patients with locally advanced gastric cancer. These patients underwent radical gastrectomy for curative intent and 27 cases received postoperative adjuvant chemotherapy. We revealed that the chemosensitivity obtained from zPDXs was consistent with the clinical responses in these patients (P = 0.029). More importantly, the responder drug(s) from zPDXs used or not was the only risk factor for early-stage recurrence in these 27 patients (P = 0.003).

Conclusion

Our study with the largest sample size so far suggests that larval zPDXs help to predict the chemotherapeutics response and to achieve precise chemotherapy for gastric cancer.
Advances in Pretreatment of Straw Biomass for Sugar Production
Authors: Tan Jinyu , Li Yan , Tan Xiang , Wu Hongguo , Li Hu , Yang Song
Published: June 2021

Straw biomass is an inexpensive, sustainable, and abundant renewable feedstock for the production of valuable chemicals and biofuels, which can surmount the main drawbacks such as greenhouse gas emission and environmental pollution, aroused from the consumption of fossil fuels. It is rich in organic content but is not sufficient for extensive applications because of its natural recalcitrance. Therefore, suitable pretreatment is a prerequisite for the efficient production of fermentable sugars by enzymatic hydrolysis. Here, we provide an overview of various pretreatment methods to effectively separate the major components such as hemicellulose, cellulose, and lignin and enhance the accessibility and susceptibility of every single component. This review outlines the diverse approaches (e.g., chemical, physical, biological, and combined treatments) for the excellent conversion of straw biomass to fermentable sugars, summarizes the benefits and drawbacks of each pretreatment method, and proposes some investigation prospects for the future pretreatments.