bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 Contact Tracing: Challenges and Future Directions
Authors: Chowdhury Mohammad Jabed Morshed , Ferdous Md Sadek , Biswas Kamanashis , Chowdhury Niaz , Muthukkumarasamy Vallipuram
Published: July 2020

Contact tracing has become a vital tool for public health officials to effectively combat the spread of new diseases, such asthe novel coronavirus disease COVID-19. Contact tracing is not new to epidemiologist rather, it used manual or semi-manualapproaches that are incredibly time-consuming, costly and inefficient. It mostly relies on human memory while scalabilityis a significant challenge in tackling pandemics. The unprecedented health and socio-economic impacts led researchersand practitioners around the world to search for technology-based approaches for providing scalable and timely answers.Smartphones and associated digital technologies have the potential to provide a better approach due to their high level ofpenetration, coupled with mobility. While data-driven solutions are extremely powerful, the fear among citizens is thatinformation like location or proximity associated with other personal data and can be weaponised by the states to enforcesurveillance. Low adoption rate of such apps due to the lack of trust questioned the efficacy and demanded researchers tofind innovative solution for building digital-trust, and appropriately balancing privacy and accuracy of data. In this paper,we have critically reviewed such protocols and apps to identify the strength and weakness of each approach. Finally, wehave penned down our recommendations to make the future contact tracing mechanisms more universally inter-operable andprivacy-preserving.
Survival Outcomes of Metastatic Colorectal Cancer Patients in Brunei Darussalam and the Impact of KRAS Mutations
Authors: Damit Datul , Patnaik Ravi , Chaw Liling , Lu Shir Kiong , Pemasiri Upali Telisinghe , Lu Zen Huat , Kok Kenneth , Lim Ya Chee
Published: July 2020

Colorectal cancer (CRC) is the third most common cancer, with rising incidence due to lifestyle and diet. 40% of CRC cases are found to have KRAS mutations. In this study, we investigate the survival outcome of metastatic Colorectal cancer mCRC) patients in Brunei Darussalam restrospectively. Chi-squared test was used to compare the survival outcomes of mCRC patients, and Mann-Whitney U test was used to compare the median ages of both groups. Kaplan-Meier survival curves were drawn and logrank test was used to compare the survival outcome between two groups. There was a total of 105 patients with stage IV CRC being treated during the study period. 81.6% (n=62) of mCRC patients were found to have the primary tumours on the left side of the colon. 19 of these 26 (73.1%) mutant KRAS mCRC patients died, while 23 of 50 (46.0%) wild-type KRAS mCRC patients died at the end of the study period, contributing to death rates of 45.2% and 54.8%, correspondingly. 30.3% (n=23) of the study population had a single metastatic site detected (either liver, or lung or any other organs), while 69.7% (n=53) of the 76 mCRC patients had two (double) or more metastatic sites. 69.2% (n=18) and 30.8% (n=8) of the mutant KRAS mCRC patients had mutations within codons 12 and 13, respectively. To our knowledge, this is the first study in Brunei Darussalam to analyse both the survival outcomes of metastatic CRC patients and those of mutant KRAS mCRC patients. Chi-squared analysis showed a significant difference between the survival outcomes of wild-type KRAS and mutant KRAS mCRC patients (p-value = 0.024). There was a significant difference in the survival outcome between the mutant KRAS mCRC patients with RCC and mutant KRAS mCRC with LCC patients. There was no significant difference between the survival outcomes of mutant KRAS patients with mutations in either codon 12 or 13 of the KRAS gene (Table 3). However, there is a significant difference in the median survival periods between the mutant KRAS mCRC patients with mutations in codon 12 and those with mutation in codon 13 of the KRAS gene (p-value = 0.003). In conclusion, we found that mutant KRAS mCRC patients had a significantly poorer OS, which was shown to be worse when the primary tumours were found at the left side of the colon. Mutant KRAS mCRC patients with mutations in codon 12 were found to have shorter survival median periods than those with mutations within codon 13.
COVID19 PCR Testing and the Unprecedented Institutional Response in a Low-Resource Setting
Authors: Orunmuyi Akintunde , Adekanmbi Olukemi , Fowotade Adeola , Adebiyi Akindele , Adeniji Adekunle , Amodu Olukemi , Olapade-Olaopa E. Oluwabunmi
Published: July 2020

The novel COVID-19 pandemic prompted an unprecedented Institutional reaction to aggregate existing capacity from silos of research laboratories to establish a multidisciplinary research laboratory for COVID19 testing. In less than two weeks, resources were mobilized from the community to strengthen public health response and epidemic control. Such strengthening of institutional research capacity to support public health response contributes to a natural knowledge transfer, facilitates collaboration, and generates new frontiers for knowledge production that should ultimately lead to professional development and retention of skilled human resources. This report describes the pre-established mechanisms and involvement of the authors that made it possible to set-up a multidisciplinary laboratory in a remarkably short period of time. We also discuss the opportunities and sustainability of multidisciplinary laboratory research post-COVID19. Existing institutional capacity can be repurposed to establish multidisciplinary research laboratories to support the strengthening of basic and clinical translational research capacity in resource limited settings and impact on public health and scientific knowledge for socioeconomic development.
Cytomegalovirus-associated Venous and Arterial Thrombotic Disease
Authors: Kelkar Amar , Loc Brian , Tarantino Michael , Rajasekhar Anita , Wang Huaping , Farrell John
Published: July 2020

Background: Cytomegalovirus (CMV) infection has been associated with venous thromboembolism (VTE) and acute coronary syndromes (ACS).

Methods: A retrospective study was conducted within the OSF HealthCare System in Peoria, Illinois. The objectives were to determine the incidence of acute VTE and ACS within one year of CMV testing. The “study group” included patients with positive CMV IgM or positive CMV Polymerase Chain Reaction (PCR). The “seropositive control” group included patients with positive CMV IgG and negative IgM. The “seronegative control” group included patients with negative CMV IgG and IgM, or negative PCR.

Results: Within one year of CMV infection, 38 of 379 patients (10.0%) developed VTE in the study group compared to 41 of 1334 patients (3.1%) in the seropositive control and 37 of 1249 (3.0%) in the seronegative control. Adjusting for age and gender, both control groups were less likely to have VTE than the study group within one year (Seropositive Control: OR = 0.3, 95% CI 0.2-0.5, p <0.0001; Seronegative Control: OR = 0.4, 95% CI 0.2-0.6, p <0.0001). ACS was more likely to occur in the study group, with incidence of 7.7% compared to 4.7% (p <0.0001) in the seropositive control and 1.9% (p <0.0001) in the seronegative control. Adjusting for age and gender, the seronegative control was less likely to develop ACS than the study group within one year (OR = 0.4, 95% CI 0.2-0.7, p = 0.003).

Conclusions: This retrospective study demonstrates that CMV infection may be a significant risk factor for VTE and ACS.
Constant-Q Gabor Atoms for Sparse Binary Representations of Cyber-Physical Signatures
Authors: Garces Milton
Published: July 2020

Data acquisition by uncalibrated, heterogeneous digital sensor systems such as smartphones present emerging signal processing challenges. Binary metrics are proposed for the quantification of cyber-physical signal characteristics and features, and a highly standardized constant-Q variation of the Gabor atom is developed for use with wavelet transforms. Two different CWT reconstruction schemas are presented and tested under different SNR conditions. A sparse representation of the Nth order Gabor atoms worked well against a test blast synthetic using the wavelet entropy and a comparable entropy-like parametrization of the SNR as the CWT coefficient-weighting functions. The proposed methods should be well suited for dictionary-based machine learning.
Dynamic Changes on Progesterone Concentration in Cow’s Milk Determined by Inline Milk Analysis System Herd Navigator
Authors: Antanaitis Ramunas , Malašauskienė Dovilė , Televičius Mindaugas , Juozaitiene Vida , Žilinskas Henrikas , Baumgartner Walter
Published: July 2020

The aim of the instant study was to evaluate relative inline progesterone dynamic changes according to parity and status of reproduction and to estimate the relationship with productivity in dairy cows by inline milk analysis system (IMAS) Herd Navigator. According to a progesterone assay, cows were divided into three periods: postpartum, after insemination, and pregnancy. In the first stage of the postpartum period (0-29 days), the progesterone level in milk was monitored every 6 days. The second stage of the postpartum period (30-65 days) lasted until cows were inseminated. In the third period (0-45 days) after cows were inseminated, progesterone scores were distributed according to whether or not cows became pregnant. The stability of progesterone dynamics was monitored in the last study period (45-90 days). For milk progesterone detection, the fully automated real-time progesterone analyzer Herd Navigator (Lattec I/S. Hillerød. Denmark) was used in combination with a DeLaval milking robot (DeLaval Inc., Tumba, Sweden). The highest progesterone concentration in multiparous cows ranged from 1.08% (11-17 days postpartum) to 34.89% higher than that in cows of the first parity. The lowest progesterone concentrations in the milk of all cows were estimated during the first 5 postpartum days and between 18 and 23 days after calving. Peak milk progesterone concentrations were evaluated in the first stage of the experiment on days 24-29 after calving. In the 30-65-day period after calving, the level of milk progesterone was 2.02-2.08 times higher than that in the 24-29-day postpartum period. After insemination, the level of progesterone in milk increased by 10.77-22.54% compared with the level from cows on days 30-65 after calving. A higher (12.88%) concentration of progesterone in milk was evaluated in multiparous cows compared with that from cows of the first parity. In pregnant cows, milk progesterone within 0-45 days after insemination was 23.88% (in multiparous cows) and 32.54% (in primiparous cows) higher than that in non-pregnant cows. On days 31–35 after insemination, pregnant cows had higher milk progesterone levels, which can predict pregnancy success. According to our study results, we can suggest that an inline progesterone concentration determined by inline milk analysis system Herd Navigator and changes in its dynamics correlate with different reproductive statuses and milk yield of cows. Pregnant cows 11–15 days after insemination have higher milk progesterone levels, what positively, associated with a successful pregnancy.
Metabolic and Molecular Mechanisms of Macrophage Polarisation and Adipose Tissue Insulin Resistance
Authors: Orliaguet Lucie , Ejlalmanesh Tina , Alzaid Fawaz
Published: July 2020

Inflammation plays a key role in the development and progression of type-2 diabetes (T2D), a disease characterised by peripheral insulin resistance and systemic glucolipotoxicity. Visceral adipose tissue (AT) is the main source of inflammation early in disease course. Macrophages are innate immune cells that populate all peripheral tissues, including AT. Dysregulated AT macrophage (ATM) responses to microenvironmental changes are at the root of aberrant inflammation and development of insulin resistance, locally and systemically. The inflammatory activation of macrophages is regulated at multiple levels: cell surface receptor stimulation, intracellular signalling, transcriptionally and metabolically. This review will cover the main mechanisms involved in AT inflammation and insulin resistance in T2D. First, we will describe the physiological and pathological changes in AT that lead to inflammation and insu- lin resistance. We will next focus on the transcriptional and metabolic mechanisms described that lead to the activation of ATMs. We will discuss more novel metabolic mechanisms that influence macrophage polarisation in other disease or tissues contexts that may be relevant to future work in insulin resistance and T2D.
Water-soluble and Cytocompatible Phospholipid Polymers for Molecular Complexation to Enhance Biomolecule Transportation to Cell in vitro
Authors: Ishihara Kazuhiko , Hachiya Shohei , Inoue Yuuki , Fukazawa Kyoko , Konno Tomohiro
Published: July 2020

Water-soluble and cytocompatible polymers were investigated to enhance a transporting efficiency of biomolecules into cells in vitro. The polymers composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) unit, a hydrophobic monomer unit, and a cationic monomer unit bearing an amino group were synthesized for complexation with model biomolecules, siRNA. The cationic MPC polymer was shown to interact with both siRNA and the cell membrane and was successively transported siRNA into cells. When introducing 20 − 50 mol% hydrophobic units into the cationic MPC polymer, transport of siRNA into cells. The MPC units (10 − 20 mol%) in the cationic MPC polymer were able to impart cytocompatibility, while maintaining interaction with siRNA and the cell membrane. The level of gene suppression of the siRNA/MPC polymer complex was evaluated in vitro and it was as the same level as that of a conventional siRNA transfection reagent, whereas its cytotoxicity was significantly lower. We concluded that these cytocompatible MPC polymers may be promising complexation reagent for introducing biomolecules into cells, with the potential to contribute to future fields of biotechnology, such as in vitro evaluation of gene functionality, and the production of engineered cells with biological functions.
PEMBERDAYAAN KELOMPOK KOPERASI WANITA PUTRI JATI EMAS MELALUI PEMBUATAN HOUSEWARE DARI LIMBAH VINIL
Authors: Nurhikmawati Agita Risma , Yuhanna Wachidatul Linda
Published: July 2020

The Empowerment of Women’s Cooperative Group Putri Jati Emas Through Houseware Making Made of Vinyl WasteAbstract. Vinyl waste is synthetic waste that is difficult to decompose. In Setono, there are 2 car upholstery and 1 shoe making industries which produce approximately 10 kg of vinyl waste per day. Thus, this study conducts vinyl waste processing by involving women's cooperative group, Putri Jati Emas. Vinyl waste is chosen since it can be made into high-selling houseware. The method in this activity is waste sorting, product designing, pattern making, printing, pattern cutting, sewing, sticking vinyl to houseware, and product finishing. In general, this activity went well and was conducive. In addition, the community is very enthusiastic and active in participating the program. In consequences, the participants’ skill level increases up to 80%.  The houseware produced are trash bins, tissue containers, snack jars, biscuit tins, trays, and flower pots. In conclusion, this program is very relevant for improving the skills of the women in supporting family income.Keywords: Houseware, waste, vinyl.Abstrak. Limbah vinil merupakan limbah sintetis yang sulit terurai dan tidak dimanfaatkan. Di Desa Setono terdapat 2 industri jok mobil dan 1 industri pembuatan sepatu yang menghasilkan limbah vinil sebanyak 10 kg per hari. Pengolahan limbah vinil dilakukan dengan melibatkan kelompok koperasi wanita Putri Jati Emas. Limbah vinil dapat dikreasikan menjadi produk houseware berdaya jual tinggi. Metode dalam kegiatan ini adalah sortasi limbah, pemaparan desain, pembuatan pola, mencetak, menggunting pola, menjahit, menempel pada produk houseware dan finishing produk. Secara umum kegiatan ini berjalan lancar dan kondusif. Masyarakat antusias dalam mengikuti pelatihan. Tingkat keterampilan masyarakat sasaran sebanyak 80%. Produk yang dihasilkan berupa tempat sampah, tempat tissue, toples, kreasi kaleng biskuit, nampan dan pot bunga. Pelatihan kreasi limbah vinil menjadi houseware sangat relevan dan bermanfaat bagi peningkatan skill kelompok Koperasi Wanita Putri Jati Emas.Kata Kunci: Houseware, limbah, vinil.
PEMANFAATAN AMPAS KEDELAI MENJADI KERUPUK UNTUK MENINGKATKAN KETERAMPILAN MASYARAKAT DESA WAKAH KECAMATAN NGRAMBE KABUPATEN NGAWI
Authors: Retno Raras Setyo , Utami Sri , Yuhanna Wachidatul Linda
Published: July 2020

Utilization of Soybean Dregs Into Crackers To Improve the Skills of the Wakah Village Community of Ngrambe Subdistrict, Ngawi RegencyAbstract. Wakah Village is one of the tofu industry villages in Ngrambe, Ngawi Regency. Tofu waste in Setono Village has not been used optimally. Solid tofu waste has nutritional content that can still be used as a potential culinary product. The product developed is soybean crackers. This community empowerment program was carried out in July 2019 with 30 participants. The method used is the delivery of material, making raw crackers, frying crackers, and packaging the product. In general, the training went well. The level of understanding of the material and skills of participants was 90%. The result show that tofu industry waste can be used as soybean crackers. An increase in the knowledge and skills of the Wakah Village community in processing tofu industrial waste into soybean crackers.Keywords: Pulp, soybean, crackers, Wakah.Abstrak. Desa Wakah merupakan salah satu desa industri tahu di Kecamatan Ngrambe Kabupaten Ngawi. Limbah tahu di Desa Setono belum dimanfaatkan secara optimal. Limbah tahu padat mempunyai kandungan gizi yang masih dapat digunakan sebagai produk kuliner yang potensial. Produk yang kembangkan adalah kerupuk ampas kedelai. Program pemberdayaan masyarakat ini dilakukan pada bulan Juli 2019 dengan peserta sejumlah 30 orang. Metode yang dilakukan adalah penyampaian materi, pembuatan kerupuk mentah, menggoreng kerupuk, dan mengemas produk. Secara umum pelatihan berjalan lancar. Tingkatpemahaman materi dan keterampilan peserta sejumlah 90%. Hasil dari program ini adalah limbah industri tahu dapat dimanfaatkan menjadi kerupuk ampas kedelai.  Adanya peningkatan pengetahuan dan keterampilan masyarakat Desa Wakah dalam mengolah limbah industri tahu menjadi kerupuk ampas kedelai. Kata Kunci: Ampas, kedelai, kerupuk, Wakah.
PENCEGAHAN STUNTING MELALUI PEMBERDAYAAN KADER PKK KECAMATAN BAREBBO DI KABUPATEN BONE
Authors: Kesumasari Citra , Kurniati Yessy , Syam Aminuddin , Salam Abdul , Virani Devintha
Published: July 2020

Prevention of Stunting  Through Empowerment of Family Welfare Programme Cadres in Barebbo District in Bone RegencyAbstract. Bone Regency has the highest prevalence of stunting under five in South Sulawesi, after Enrekang district. Family Welfare Programme (PKK) cadres are often empowered in overcoming various problems in the community. This dedication activity aims to empower PKK cadres to prevent stunting in the Barebbo District, Bone Regency. Audience The target of this training is PKK cadres in Barebb Subdistrict. The Community Service Method is to provide training to PKK cadres on stunting prevention. The training was carried out in two ways, namely by providing material on stunting and demonstrations on how to screen stunting to children through anthropometric measurements. Based on the results of the activities carried out, it appears that the training carried out has increased the knowledge of PKK cadres who were trained in the good category by 54.5%. This is in accordance with established indicators of success. The training carried out effectively increased the knowledge and skills of PKK cadres in conducting anthropometric measurements. This is important in preventing stunting in infants. PKK cadres who have been trained are expected to be able to contribute significantly in screening the status of toddlers in the community.Keywords: Toddlers, stunting, prevention, anthropometry. Abstrak. Kabupaten Bone menjadi kabupaten yang memiliki prevalensi balita stunting tertinggi di Sulawesi Selatan, setelah kabupaten Enrekang. Kader PKK sering diberdayakan dalam mengatasi berbagai masalah dalam masyarakat. kegiatan pengabdian ini bertujuan untuk memberdayakan kader PKK untuk mencegah terjadinya stunting di Kecamatan Barebbo, Kabupaten Bone. Khalayak Sasaran pada pelatihan ini adalah kader PKK di Kecamatan Barebbo.Metode Pengabdian yang dilakukan adalah dengan memberikan pelatihan kepada kader PKK tentang pencegahan stunting. Pelatihan tersebut dilakukan dengan dua cara, yaitu dengan pemberian materi tentang stunting dan demonstrasi tentang cara melakukan skreening stunting pada balita melalui pengukuran antropometri. Berdasarkan hasil kegiatan yang telah dilakukan, terlihat bahwa pelatihan yang dilakukan telah meningkatkan pengetahuan kader PKK yang dilatih pada kategori baik sebesar 54,5%. Hal ini telah sesuai dengan indikator keberhasilan yang telah ditetapkan. Pelatihan yang dilakukan efektif meningkatkan pengetahuan dan keterampilan kader PKK dalam melakukan pengukuran antropometri. Hal tersebut penting dalam melakukan pencegahan stunting pada balita. Kader PKK yang telah dilatih diharapkan mampu berkontribusi secara nyata dalam melakukan skreening status balita di masyarakat.Kata Kunci : Balita, stunting, pencegahan, antropometri
INTRODUKSI INDUKAN DAN ALIH TEKNOLOGI PEMBENIHAN LOBSTER AIR TAWAR (CERAX QUADRICARINATUS) PADA KELOMPOK MASYARAKAT DI KECAMATAN LADONGI KABUPATEN KONAWE TIMUR
Authors: Yusnaini Yusnaini , Ramli Muhammad , Saenong Zainuddin , Nur Indriyani , Indrayani Indrayani
Published: July 2020

Broodstock Introduction and Technology Transfer of Crayfish (Cerax quadricarinatus) Hatchery in the Community Groups in Ladongi Subdistrict, East Konawe RegencyAbstract. Crayfish is an introduced species that has the potential to be developed.  However, Its development is hindered by the availability of the seeds. The aim of this activity was to transfer  crayfish hatchery technology into two community groups in Ladongi Subdistrict, East Konawe  Regency. These activities were conducted from 2017-2018. The forms of activities were hatchery extension/training, introduction of crayfish broodstocks, contruction of breeding ponds and hatcheries and evaluation of knowledge, skills, availability of production facilities and the ability of partners to produce caryfish seeds. The results showed that the knowledge level of participants based on indicators was 55-91%., from know nothing to know many things about crayfish.  The skill level of participants based on indicators was 64-100%, from unable to be able to seed crayfish. Both groups are able to manage resources and produce seeds, and as crayfish suppliers. In addition to seed production, the groups also produce crayfish for consumption and for broodstocks. Keywords: Crayfish, hatcheries, technology transfer, community groups.Abstrak. Lobster air tawar (LAT) merupakan spesies introduksi yang potensi dikembangkan, namun terkedala pada ketersediaan benih.Kegiatan ini bertujuan mentransfer teknologi pembenihan LAT kepada dua kelompok masyarakat di Kecamatan Ladongi Kabupaten Kolaka Timur. Kegiatan direalisasikan tahun 2017-2018. Bentuk kegiatan yaitu  penyuluhan/pelatihan pembenihan, introduksi indukan LAT, konstruksi kolam indukan dan pembenihan. Evalusi tingkat pengetahuan, keterampilan, ketersediaan sarana produki dan kemampuan mitra memproduksi benih LAT. Hasil kegiatan menunjukan bahwa, tingkat serapan pengetahuan peserta berdasarkan indikator yaitu 55-91%, dari tidak tahu menjadi tahu tentang LAT. Tingkat keterampilan peserta berdasarkan indikator 64-100 %, dari tidak bisa menjadi bisa membenihkan LAT. Kedua kelompok mampu mengelola sumberdaya dan memproduksi benih, sebagai penyuplaiLAT. Selain bentuk benih kelompok memproduksi LAT ukuran konsumsi dan indukan bertelur.Kata Kunci: Lobster air tawar, pembenihan, alih teknologi, kelompok masyarakat
ANALISIS PENGARUH PERAN PARTISIPASI ANGGARAN TERHADAP KINERJA MANAJERIAL DENGAN MODERASI LOCUS OF CONTROL DAN BUDAYA ORGANISASI (Studi pada Satuan Kerja Perangkat Daerah Pemerintah Kota Semarang)
Authors: Rahardja Rahardja , Andriyanto Irsad
Published: July 2020

This study was aimed to analyze the role of locus of control and organizational culture on the relationship between budgetary participation and managerial performance. Participation budget has been empirically tested positive influence on managerial performance. The study provides further explanation of the relationship by testing the moderating effects of locus of control and organizational culture, especially at the level of Satuan Kerja Perangkat Daerah (SKPD) Municipality of Semarang. The results showed that locus of control and organizational culture moderate the effect of budget participation on the performance majarial. The results of this study are expected to provide solutions in increasing performance on education so as to create good governance. The results of this study will contribute to the research-previous research, strengthen existing research concerning the relationship influence of budget participation and managerial performance, and to clarify the contingency factors that locus of control and organizational culture.
DEKONSTRUKSI MAKNA TRANSAKSI DALAM AKUNTANSI: SUATU PENDEKATAN IDEALISME SYARIAH ISLAM
Authors: Robinson Robinson
Published: July 2020

Sesuai dengan fungsi filsafat yakni merumuskan kembali muatan moral dan nilai bagi landasan bangunan sains modern, maka akuntansi sebagai bagian dari sains dan teknologi juga harus merumuskan kembali muatan-muatan moral dan nilai dalam kerangka pengetahuan akuntansi tersebut.  Salah satu upaya yang dapat dilakukan untuk merumuskan muatan moral dan nilai dalam akuntansi, yakni dengan memasukkan unsur-unsur nilai moral dalam setiap makna dari definisi akuntansi.  Salah satu kata kunci dari definisi akuntansi adalah transaksi, dimana transaksi menjadi dasar apa yang akan dicatat, diikhtisar dan dilaporkan.  Sehingga sangat penting untuk memastikan makna dari suatu transaksi, serta muatan nilai dan moral didalamnya, apakah suatu kejadian memenuhi kriteria sebagai suatu transaksi atau tidak akan menentukan apakah dapat diproses secara akuntansi atau tidak. Makalah ini mencoba untuk merumuskan muatan moral dan nilai dalam lingkup makna transaksi yang merupakan dasar adanya praktik pencatatan serta proses selanjutnya dalam akuntansi.  Adapun sumber utama dari muatan moral dan nilai adalah dari ajaran agama (dalam makalah ini merujuk pada ajaran agama Islam).  Makna transaksi dalam pandangan Islam dapat di dekonstruksi menjadi suatu akad (tentang kejadian ekonomi) terhadap barang/jasa yang melibatkan dua pihak atau lebih, dimana baik akad, objek maupun pelakunya harus memenuhi rukun dan syarat transaksi sesuai dengan syariat Islam. Pelaku transaksi, dalam suatu transaksi harus jelas keberadannya serta memenuhi kriteria diantaranya adalah berakal. Selain itu menurut syariat Islam pelaku transaksi tidak boleh melanggar prinsip menzhalimi dan dizhalimi serta tidak diperbolehkan menciptakan ketidakpastian (gharar).  Sesuai rukun transaksi dalam syriat Islam, objek transaksi harus jelas keberiadaannya serta tidak boleh melanggar prinsip halal dan haramnya.  Selain itu, objek yang ditransaksikan juga tidak boleh mengandung ketidakpastian dari segi harga, kualitas, kuantitas dan waktu.  Akad transaksi akan batal apabila terdapat kesalahan/kekeliruan objek, paksaan (ikrah), penipuan (tadlis).  Selanjutnya, yang tidak kalah penting adalah bahwa dalam suatu akad transaksi tidak boleh ada unsur riba didalamnya.
DESTINASI WISATA RELIGI: SOLUSI PENINGKATAN PEREKONOMIAN PELAKU WISATA DI KUDUS
Authors: Rosyid Moh
Published: July 2020

Stabilnya sumber perekonomian warga merupakan tugas utama pemerintah dalam mewujudkan kesejahteraan. Dalam konteks Kota Kudus, semakin muramnya industri kretek karena ragam kebijakan yang menghimpit, Pemkab Kudus perlu mengoptimalkan sumber ekonomi lain sebagai penopang kehidupan warga. Destinasi wisata merupakan alternatif utama yang perlu dioptimalkan agar penopang sumber ekonomi terwujud. Bentuk riil yang harus dilakukan Pemkab Kudus memberi kemudahan dalam hal (1) akses permodalan, (2) pembangunan infrastruktur, (3) ketersediaan area wisata yang nyaman, (4) pembekalan dalam peningkatan sumber daya kepariwisataan, (5) publikasi, dan (6) terwujudnya keamanan dan kenyamanan wisatawan.  Upaya ini perlu dievaluasi dengan melibatkan unsur pemerintah daerah, pemerhati wisata, akademisi, dan tokoh masyarakat agar kinerja dan produktivitas destinasi wisata berjalan optimal. Pelibatan investor dan industriawan juga perlu dioptimalkan sebagai ‘bapak asuh’ program kerja kepariwisataan. Kekompakan semua elemen dan stakeholders dunia pariwisata merupakan modal utama terciptanya perekonomian warga Kudus di tengah muramnya industri kretek.
Strategi Pendidikan Entrepreneurship di Pesantren Al-Mawaddah Kudus
Authors: Afandi Zaenal
Published: July 2020

Generally Boarding School take religious and morals material as the most priority, but ignoring skills. The consequences is Boarding School graduates always feeling awkward when back to their hometown. Facing that condition, entrepreneurship education become one of concrete solution. This research describe about entrepreneurship education strategy in Al-Mawaddah Boarding School Centre Honggosoco Jekulo Kudus. This reseach belong to field research. Researcher collect data using interview method, observation and documentation. While for the analysts researcher using qualitative descriptive analyst thechniques. This research is held in Al-Mawaddah Boarding School Centre Honggosoco Jekulo Kudus. The result of this research showing that 1). The implementation of entrepreneurship education runs effectively. It can be seen from material that have been submitted and enthusiasm of the santri in running the entrepreneur owned by the Boarding School. 2) is the development strategy of entrepreneurship education in Al Mawaddah Boarding School quite successful that proved by the growing entrepreneurship of Boarding School.
Peningkatan Kepatuhan Wajib Pajak melalui Penerapan Sistem e-filling yang Dimoderasi oleh Pemahaman Internet
Authors: Aminudin Moch , Ali Ali , Subadriyah Subadriyah
Published: July 2020

Taxes are the largest source of state revenue that has many roles. Until 2017 taxes can contribute 85.6% of state revenues. The level of taxpayer compliance in Indonesia is quite alarming and continues to decline, in 2011 taxpayer compliance could reach 97.2%, but in 2014 it fell to 91.6%, and again in 2015 only 82%. The purpose of this study was to determine the effect of the implementation of the efilling system on taxpayer compliance and to know the relationship between the application of e-filling systems and taxpayer compliance which was moderated by internet understanding. The initial step as the main basis of research is by collecting data. Primary data obtained from the distribution of questionnaires. All taxpayers registered with the Tax Office as the study population. Determination of the sample was obtained by the Slovin formula so that 100 respondents were obtained. The analysis method uses simple linear regression and the Moderated Regression Analysis (MRA) method. The results obtained are that the application of e-filling system has a significant effect on taxpayer compliance and internet understanding is able to moderate the relationship between the application of e-filling systems to taxpayer compliance.
Investor’s Mood at ASIAN Games Event
Authors: Devy Happy Sista , Irawan Bahrain Pasha
Published: July 2020

Goals of the research to analyze whether occurred abnormal return of ASIAN Games phenomena and see how investors react to the big ASIAN Games 2018 event in Indonesia. . This reseach uses a sample of companies included in the hotel, restaurant and tourism sub-sector on the Indonesia Stock Exchange (IDX) during the observation period, based on the purposive sampling method which obtained 22 companies and used the event study method. There is a significant abnormal return but not on the phenomenon of the Asian Games 2018. This shows that investors still wait and see to the organization of the Asian Games in 2018. No difference of abnormal return before and after the Asian Games 2018. This is because, as investors look to the many tourists who have started to flock to Indonesia before the Asian Games in 2018 took place.
Minat Beli Online Generasi Milenial: Pengaruh Kepercayaan dan Kualitas Layanan
Authors: Hana Kharis Fadlullah
Published: July 2020

Buying and selling online is a transaction that is in high demand by the current millennial generation. The ease, efficiency, variety of choices and various promotions offered are the underlying factors for millennials to make online purchases. This can also be seen from the shift in the style of buying the younger generation from traditional markets to online stores that are increasing. Despite the many advantages and advantages offered, there are some consumers who are less satisfied with their purchases online. That is caused by poor service quality because sometimes the response from the seller to the buyer is quite long. Some sellers who give goods that are not in accordance with the offer also cause public confidence to decline. Based on these phenomena, this study aims to determine the effect of service quality and trust in millennial generation consumers' buying decisions and decisions. This research method uses quantitative methods with a Post positivism approach with Structural Equation Model analysis techniques using the WarpPls 6.0 analysis tool. Service quality and trust as exogenous variables, buying interest and online purchasing decisions as endogenous variables. The object of this research is millennial consumers in the cities of Kudus, Jepara and Pati who purchase goods online with a total sample of 375 respondents. The results showed that trust through interest influenced the online buying decision of 0.293. Trust and interest have a total influence of 0.402. Quality of service through interest affects the decision of 0.143. Service quality and interest have a total influence on online buying decisions of 0.363. This means that trust has a greater influence on buying decisions on digital generation compared to service quality.
Pengaruh Gaya Kepemimpinan Transformasional dan Tranksaksional Terhadap Kinerja Sistem Jaminan Halal HAS 23000
Authors: Yanthy Evy , Purwanto Agus , Pramono Rudy , Cahyono Yoyok , Asbari Masduki
Published: July 2020

This study aims to analysis of transformational and transactional leadership styles and their effects on the performance of the HAS 23000 Halal Assurance System implementation in the food industry in Tangerang. The respondents of the study was employees in several food industries that were located in the Tangerang  who had implement the HAS 23000 Halal Assurance System as many as 200 employees and data collection methods by giving online electronic questionnaires to 2000  employees randomly. The analytical tool used in this study is the SEM (Structural Equation Model) on the LISREL program version 8.70. This study provides results that show that transformational leadership style has a positive and significant effect on the performance of the HAS 23000 Halal Assurance System implementation and the transactional leadership style is also positive and affects the performance of the HAS 23000 Halal Assurance System implementation and concluded that leadership is important in the performance of the HAS Halal Assurance System implementation HAS 23000
Состояние проблемы разработки вакцин для специфической профилактики COVID-19
Authors: Бугоркова Светлана
Published: July 2020

На сегодняшний день не вызывает сомнения важность решения вопроса с созданием эффективной и безопасной вакцины для борьбы с COVID-19. В обзоре представлены материалы по перспективным достижениям в разработке вакцин-кандидатов против SARS-CoV-2. Проанализирован текущий трек создаваемых вакцин-кандидатов против SARS-CoV-2 по данным на 08.07 2020 г. с позиции оценки их эффективности и безопасности. Выделены наиболее перспективные разработки, реализуемые в ближайшее время. Показано, что активное создание и оценка разрабатываемых вакцин против SARS-CoV-2 позволит иметь богатую альтернативу при выборе препарата по цене и эффективности и накопить потенциальный опыт для разработки вакцин против вновь появляющихся вирусов.
Lumbar Facet Joint Radiofrequency Ablation Versus Intra-articular Lumbar Facet Joint Injections Using Corticosteroids in the Reduction of Chronic Low Back Pain Related to the Facet Joints
Authors: Chavez Eric M.
Published: July 2020

Purpose:

The purpose of this article is to review nonoperative treatment for chronic low back pain (CLBP) related to facet joint dysfunction and to compare the long-term pain reduction and functional improvement with lumbar facet joint (LFJ) radiofrequency (RF) ablation vs. intra-articular (IA) LFJ injections using corticosteroids.

Method:

A systematic search of databases included PubMed and Google Scholar. Search terms included low back pain, facet joint dysfunction, injection, corticosteroid, and RF. The search resulted in several hundred results. An advanced MeSH term search was then used to limit the effect to within the past 10 years with variations of the terms mentioned above to further narrow the results to address the clinical question which resulted in 94 citations.

Results:

There were satisfactory results using PubMed Advanced Search Builder to include several comparative systematic reviews and randomized controlled trials. Excluded were studies that were broad in their comparisons, including those which included treatments with physical activity modifications, oral medications, physiotherapy, and chiropractic manipulation.

Conclusion:

Studies suggest that there is a moderate amount of improvement in the short-term (less than 6 months) for both IA LFJ injections using corticosteroids and LFJ RF ablation; however, the RF ablation had better results for the middle (6 to 12 months) to long-term (greater than 12 months). The results established by the author's review suggest that although LFJ RF ablation and IA LFJ injections using corticosteroids are equally effective in the short-term pain management of patients with CLBP, RF is the more effective treatment for long-term pain management in patients with CLBP related to facet joint dysfunction.
Multiple Phases of Mountain Building on the Northern Tibetan Margin
Authors: Wang Fei , Shi Wenbei , Zhang Weibin , Yang Liekun , Wang Yinzhi
Published: July 2020

The history of mountain building along the northern Tibetan margin since its initiation remains unclear. The exhumation evolutionary history of the Kunlun Belt, the first-order mountain range of northern Tibet, is resolved by using 40Ar/39Ar thermochronological analyses of Paleozoic and Mesozoic granitic intrusions. Four rapid exhumation events are identified from analyses employing multiple domain diffusion theories in the Carboniferous (~355-295 Ma), Triassic (~245-205 Ma), Cretaceous (~120-95 Ma), and Eocene (~40-35 Ma). The cooling rates and the therefrom deduced denudation rates are estimated for these stages. The events are interpreted to reflect the closure of the Prototethys Ocean in the early Paleozoic, closure of the Paleotethys ocean in the late Paleozoic, far-field effects from the closure of the Mesotethys Ocean, and far-field effects from the Paleogene convergence of India and Eurasia, respectively. These events collectively built up the present northern Tibetan margin.
Taxonomy and Evolution of Visean–Roadian (Late Mississippian–Guadalupian) Lasiodiscidae
Authors: Kulagina Elena I. , Filimonova Tatiana V.
Published: July 2020

The study of the test morphology of type specimens and newly collected foraminiferal material of the family Lasiodiscidae Reitlinger, 1956, from the Carboniferous (Visean Stage, Mississippian Subsystem) to Permian (Roadian Stage, Guadalupian Series) beds of Russia (East European Platform and Urals), Turkey, and Tajikistan (Darvaz) allowed a revision of the species composition of the genera Howchinia, Monotaxinoides, Eolasiodiscus, Turrispiroides, and Mesolasiodiscus. A new genus, Postmonotaxinoides, is described. The species Monotaxinoides transitorius, M. subplanus, M. gracilis, Eolasiodiscus donbassicus, E. galinae, Mesolasiodiscus tenuis, M. nigrans, Postmonotaxinoides horridus, P. costiferus, and P. grandis are redescribed based on new data of their test morphology. Their taxonomy is revised and new phylogenetic reconstructions for the species are proposed.
LA DOCTRINA DE LA ARGUMENTACIÓN INSUFICIENTE DEL “DAÑO DIRECTO” COMO RATIO DE LA DESESTIMACIÓN DE LA ACCIÓN INDIVIDUAL DE RESPONSABILIDAD CIVIL CONTRA EL ADMINISTRADOR (NOTAS CRÍTICAS)
Authors: Alonso Espinosa Francisco J.
Published: July 2020

La doctrina Tribunal Supremo en materia de estimación de la acción individual deresponsabilidad civil contra el administrador ex art. 241 de la Ley de Sociedades de Capital (LSC), se caracteriza, en general, por responder a una política jurídica restrictiva o indulgente a favor de los administradores demandados. Cuando esta acción es ejercitada sobre la base de la infracción del deber de promoción de la disolución y liquidación de la sociedad, entre otros hechos antijurídicos, en función de obtener la condena del administrador a indemnizar el daño causadopor el impago de deudas sociales anteriores al acaecimiento de causas de disolución, el Tribunal Supremo exige al demandante, como requisito adicional a los presupuestos ordinarios de nacimiento de la obligación resarcitoria, la realización de un "esfuerzo argumentativo" para la eventual estimación de tales acciones. En este artículo se realizan algunas consideraciones críticas sobre tal doctrina.
El contrato de suministro y el foro especial por razón de la materia del art. 7.1 b) del Reglamento Bruselas I bis
Authors: Lorente Martínez Isabel
Published: July 2020

El contrato es el principal medio en el comercio internacional que sirve para que circule la riqueza y el capital sin que la división del mundo en Estados sea unimpedimento para ello. En este trabajo se estudia la incidencia del concepto europeo de compraventa internacional de mercaderías y el contrato de suministro.Con el objetivo de dilucidar los tribunales competentes en un supuesto de controversia, para fundar su competencia judicial internacional en el artículo 7.1 b) del Reglamento Bruselas I bis.
Front-matter
Authors: Siregar Tongku Nizwan
Published: July 2020

Cover Vol. 14 No. 1: March 2020
Preterm intraventricular hemorrhage in vitro: modeling the cytopathology of the ventricular zone
Authors: Castaneyra-Ruiz Leandro , McAllister James P. , Morales Diego M. , Brody Steven L. , Isaacs Albert M. , Limbrick David D.
Published: July 2020

Background: Severe intraventricular hemorrhage (IVH) is one of the most devastating neurological complications in preterm infants, with the majority suffering long-term neurological morbidity and up to 50 percent developing post-hemorrhagic hydrocephalus (PHH). Despite the importance of this disease, its cytopathological mechanisms are not well known. An in vitro model of IVH is required to investigate the effects of blood and its components on the developing ventricular zone (VZ) and its stem cell niche. To address this need, we developed a protocol from our accepted in vitro model to mimic the cytopathological conditions of IVH in the preterm infant. Methods: Maturing neuroepithelial cells from the VZ were harvested from the entire lateral ventricles of wild type C57BL/6 mice at 1-4 days of age and expanded in proliferation media for 3-5 days. At confluence, cells were re-plated onto 24-well plates in differentiation media to generate ependymal cells (EC). At approximately 3-5 days, which corresponded to the onset of EC differentiation based on the appearance of multiciliated cells, phosphate-buffered saline for controls or syngeneic whole blood for IVH was added to the EC surface. The cells were examined for the expression of EC markers of differentiation and maturation to qualitatively and quantitatively assess the effect of blood exposure on VZ transition from neuroepithelial cells to EC. Discussion: This protocol will allow investigators to test cytopathological mechanisms contributing to the pathology of IVH with high temporal resolution and query the impact of injury to the maturation of the VZ. This technique recapitulates features of normal maturation of the VZ in vitro, offering the capacity to investigate the developmental features of VZ biogenesis.
Activation and enhancement of Caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies
Authors: Xie Yunchang , Chen Jiawen , Wang Bo , Chen Tai , Chen Junyu , Zhang Yuan , Liu Xiaoying , Chen Qi
Published: July 2020

Backgrounds: Activation of silent biosynthetic gene clusters (BGCs) in marine-derived actinomycete strains is a feasible strategy to discover bioactive natural products. Actinoalloteichus sp. AHMU CJ021, isolated from the seashore, was shown to contain an intact but silent caerulomycin A (CRM A) BGC-cam in its genome. Thus, a genome mining work was preformed to activate the strain’s production of CRM A, an immunosuppressive drug lead with diverse bioactivities.Results: To well activate the expression of cam, ribosome engineering was adopted to treat the wild type Actinoalloteichus sp. AHMU CJ021. The initial mutant strain XC-11G with gentamycin resistance and CRM A production titer of 42.51 ± 4.22 mg/L was selected from all generated mutant strains by gene expression comparison of the essential biosynthetic gene-camE. The titer of CRM A production was then improved by two strain breeding methods via UV mutagenesis and cofactor engineering-directed increase of intracellular riboflavin, which finally generated the optimal mutant strain XC-11GUR with a CRM A production titer of 113.91 ± 7.58 mg/L. Subsequently, this titer of strain XC-11GUR was improved to 618.61 ± 16.29 mg/L through medium optimization together with further adjustment derived from response surface methodology. In terms of this 14.6 folds increase in the titer of CRM A compared to the initial value, strain XC-GUR could be a well alternative strain for CRM A development.Conclusions: Our results have constructed an ideal CRM A producer. More importantly, our efforts also have demonstrated the effectiveness of abovementioned combinatorial strategies, which is applicable to the genome mining of bioactive natural products from abundant actinomycetes strains.
A Modified Mini Incision for The Surgery of Parotid Benign Tumor: A Retrospective Analysis of 48 Cases
Authors: Jin Mang , Zhu Wei , Wang Chengyu , Jiang Hui
Published: July 2020

Background: Parotid neoplasm is a result of inadequate surgical incision during the treatment of head and neck cancers, and most of them are benign tumors. Hence, to explore a new surgical incision for parotid benign tumor in order to minimize the scar size on the premise of guaranteeing the safety of operation.Methods: We conducted a retrospective study of 48 patients who had undergone parotid surgeries from Jan. 01 2008 to Dec. 30 2014 at the department of otolaryngology, Jinshan Hospital of Fudan University. Histopathological examination confirmed benign parotid tumor (Warthin's tumor, pleomorphic adenoma, cysts, and monomorphic adenomas.) in all cases. All patients underwent a mini incision (cutting the skin directly on the surface of the tumor, and the incision was slightly longer than the diameter of the tumor). Results: Among the 48 cases, no recurrence and facial nerve injury were reported during the follow-up period of more than 4 years. Two cases of saliva fistula and one case of temporary facial nerve dysfunction were reported; however, they recovered quickly after symptomatic treatment.Conclusion: Extracapsular dissection is a safe and effective surgical procedure for the treatment of parotid benign tumor, and the postoperative scar is very small.