bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comprehensive Taxonomy for Prediction Models in Software Engineering
Authors: Yang Xinli , Liu Jingjing , Zhang Denghui
Published: February 2023

Applying prediction models to software engineering is an interesting research area. There have been many related studies which leverage prediction models to achieve good performance in various software engineering tasks. With more and more researches in software engineering leverage prediction models, there is a need to sort out related studies, aiming to summarize which software engineering tasks prediction models can apply to and how to better leverage prediction models in these tasks. This article conducts a comprehensive taxonomy on prediction models applied to software engineering. We review 136 papers from top conference proceedings and journals in the last decade and summarize 11 research topics prediction models can apply to. Based on the papers, we conclude several big challenges and directions. We believe that the comprehensive taxonomy will help us understand the research area deeper and infer several useful and practical implications.
Vibration Diagnostic Methods of Automatic Transmission Service Requirement Prediction
Authors: Őri Péter , Kocsis Szürke Szabolcs , Kurhan Dmytro , Sysyn Mykola , Lakatos István , Fischer Szabolcs
Published: February 2023

Automatic transmission is a key factor for autonomous driving. The transmission condition is highly affected by the quality and quantity of transmission oil in the system. However, the oil condition is not monitored in the system, and the oil change interval and method are still a subject of discussion. This paper analyzes the effects of oil changes in automatic transmissions. The measurements were carried out before and after the oil change with the same external conditions. With the vibration measurement method, data can be collected without disassembling the parts and during operational conditions. Furthermore, time- and frequency-based analyses were conducted to compare different transmissions’ operations. The results have shown that the effect of oil degradation is measurable on the amplitude of the signals and, therefore, predictable with vibration diagnostics. During the evaluation, the maximum values were compared on measurements with at least a 2-s length.
Effect of the Solvent on the Crystallographic and Magnetic Properties of Rhenium(IV) Complexes Based on 2,2′-Bipyrimidine Ligand
Authors: Sanchis-Perucho Adrián , Orts-Arroyo Marta , Moliner Nicolas , Martínez-Lillo José
Published: February 2023

Two solvated rhenium(IV) complexes with formula [ReCl4(bpym)]·MeCN (1) and [ReCl4(bpym)]·CH3COOH·H2O (2) (bpym = 2,2′-bipyrimidine) have been prepared and characterized by means of Fourier transform infrared spectroscopy (FT–IR), scanning electron microscopy and energy dispersive X-ray analysis (SEM–EDX), single-crystal X-ray diffraction (XRD) and SQUID magnetometer. 1 and 2 crystallize in the monoclinic system with space groups P21/n and P21/c, respectively. In both compounds, the Re(IV) ion is six-coordinate and bound to four chloride ions and two nitrogen atoms of a 2,2′-bipyrimidine molecule forming a distorted octahedral geometry around the metal ion. In the crystal packing of 1 and 2, intermolecular halogen⋯halogen and π⋯halogen-type interactions are present. Hydrogen bonds take place only in the crystal structure of 2. Both compounds exhibit a similar crystal framework based on halogen bonds. Variable temperature dc magnetic susceptibility measurements performed on microcrystalline samples of 1 and 2 show a similar magnetic behavior for both compounds, with antiferromagnetic exchange between the Re(IV) ions connected mainly through intermolecular Re-Cl⋯Cl-Re interactions.
Preparing a Ca-Bi-O System by the Precipitation Method and Studying Its Intermediate Structural Properties for Applications in Water Treatment
Authors: Cadiș Adrian Ionuț , Rus Florina Ștefania , Gonçalves João Nuno , Ivanovici Mădălina
Published: February 2023

This study focuses on the development of a Ca-Bi-O system (CBO) with efficiency in the degradation of Rhodamine B, which is extremely toxic to many organisms and can have long-term negative consequences if not safely removed from the water. The conventional precipitation method was used to create a stable phase of Ca2Bi2O5 with a stoichiometric 1:1 molar ratio of Ca:Bi. Before obtaining the pure phase, the details of the reaction processes were investigated and the various intermediate products were identified using X-ray diffraction followed by Fourier transform infrared, UV-Vis, and Raman spectroscopy. An ab initio calculation evaluated with the HSE06 functional yields a band gap of 3.5 eV, similar to the band gap obtained by diffuse reflectance recorded on Ca2Bi2O5. This newly synthesized compound is addressed to the environmental application by investigating the photocatalytic properties of CBO materials obtained at different calcination temperatures. The investigation of pure Ca2Bi2O5, with characterization techniques and complemented by new first-principles calculations to investigate the photocatalysis provide valuable new insights for this scarcely studied yet potentially interesting compound.
Functionally Validating Evolutionary Conserved Risk Genes for Parkinson’s Disease in Drosophila melanogaster
Authors: Baisgaard Amalie Elton , Koldby Kristina Magaard , Kristensen Torsten Nygård , Nyegaard Mette , Rohde Palle Duun
Published: February 2023

Parkinson’s disease (PD) is a heterogeneous and complex neurodegenerative disorder and large-scale genetic studies have identified >130 genes associated with PD. Although genomic studies have been decisive for our understanding of the genetic contributions underlying PD, these associations remain as statistical associations. Lack of functional validation limits the biological interpretation; however, it is labour extensive, expensive, and time consuming. Therefore, the ideal biological system for functionally validating genetic findings must be simple. The study aim was to assess systematically evolutionary conserved PD-associated genes using Drosophila melanogaster. From a literature review, a total of 136 genes have found to be associated with PD in GWAS studies, of which 11 are strongly evolutionary conserved between Homo sapiens and D. melanogaster. By ubiquitous gene expression knockdown of the PD-genes in D. melanogaster, the flies’ escape response was investigated by assessing their negative geotaxis response, a phenotype that has previously been used to investigate PD in D. melanogaster. Gene expression knockdown was successful in 9/11 lines, and phenotypic consequences were observed in 8/9 lines. The results provide evidence that genetically modifying expression levels of PD genes in D. melanogaster caused reduced climbing ability of the flies, potentially supporting their role in dysfunctional locomotion, a hallmark of PD.
Within-Plant and Within-Field Distribution Patterns of Asian Bean Thrips and Melon Thrips in Snap Bean
Authors: Adhikari Rosan , Seal Dakshina R. , Schaffer Bruce , Liburd Oscar E. , Khan Rafia A.
Published: February 2023

Asian bean thrips, Megalurothrips usitatus Bagnall, are a serious pest of vegetable crops, especially leguminous crops, across the Asian continent. In Florida, it is a new invasive pest of snap beans. In 2019, it was recorded for the first time in the United States in snap bean (Phaseolus vulgaris) fields. Another thrips species, melon thrips, Thrips palmi Karny, is also a serious pest that affects several vegetable crops. Within-plant and within-field distribution patterns of M. usitatus and T. palmi were determined in snap bean fields in southern Florida. The highest number of both thrips species (Asian bean thrips and melon thrips) in snap beans were in flowers, followed by leaves and pods. Both adults and immatures of these thrips exhibited regular to clumped distribution patterns in bean fields. Several statistical indices showed agreement in the distribution patterns of Asian bean thrips, melon thrips, and larvae, irrespective of sampling units and plot size, in three years of study. In most instances, the distribution of Asian bean thrips and melon thrips was aggregated. This study assessed the optimum sample size to accurately determine the population density of these thrips for management purposes. The results from this study will be useful for implementing targeted management programs against thrips pests, thereby reducing labor costs and time. This information will also help reduce agrochemical use.
Chlorantraniliprole Residual Control and Concentration Determination in Cotton
Authors: Smith Jacob , Crow Whitney D. , Catchot Angus L. , Cook Donald R. , Gore Jeffrey
Published: February 2023

Studies were conducted in 2020 and 2021 at the Delta Research and Extension Center in Stoneville, MS, to determine the residual concentrations of chlorantraniliprole in cotton (Gossypium hirsutum, L.) leaves, as well as the concentrations in petals and anthers that developed after the time of application. Foliar applications of chlorantraniliprole were applied at four rates for leaves and two rates for petals and anthers at the second week of bloom. Additional bioassays were conducted to determine mortality of corn earworm (Helicoverpa zea, Boddie) in anthers. For the leaf study, plants were partitioned into three zones consisting of top, middle, and bottom zones. Leaf samples from each zone were analyzed for chemical concentrations at 1, 7, 14, 21, and 28 days after treatment (DAT). Residual concentrations, although variable, persisted through all sampling dates, rates, and zones tested. In this study, chlorantraniliprole remained detectable up to 28 DAT. Results from the cotton flower petal and anther studies detected concentrations of chlorantraniliprole in petals at 4, 7, 10, and 14 DAT, but no concentrations were detected in anthers. Therefore, no mortality of corn earworm was recorded in the anther bioassays. A series of diet-incorporated bioassays were conducted using concentrations previously found in the petal study to determine baseline susceptibilities of corn earworms and predicted mortality. Results from the diet-incorporated bioassays showed similar susceptibility in field and lab colony corn earworms. Concentrations of chlorantraniliprole could provide up to 64% control of corn earworm when feeding occurs on the petals.
Cascading Effects of Cover Crops on the Subsequent Cash Crop Defense against the Polyphagous Herbivore Fall Armyworm (Spodoptera frugiperda)
Authors: Fajemisin Adegboyega , Racelis Alexis , Kariyat Rupesh
Published: February 2023

Recent studies have started to show that the benefits of cover crops can cascade to the cash crop growing seasons. However, the impact of cover crops on the subsequent cash crop defense against herbivores is not well understood. To test this, we conducted a field and laboratory study to assess the possible cascading effects of cover crops such as Vigna unguiculata, Sorghum drummondii, Raphanus sativus, and Crotalaria juncea on the subsequent cash crop (Sorghum bicolor) defense against the notorious polyphagous herbivore fall armyworm (Spodoptera frugiperda) across three farms in the Lower Rio Grande Valley. Our field and laboratory studies showed that the cash crop planted in the cover crop treatment differentially affected S. frugiperda. More specifically, we found that cover crops have positive effects on the growth and development of S. frugiperda on the subsequent cash crop, including both larval and pupal parameters. However, our experiments on physical and chemical defenses in cash crops failed to show any significant differences between cover and control. Collectively, our results add an additional line of evidence on the effects of cover crops on pest dynamics outside the cash crop season, a key consideration for the selection and management of cover crops and cash crops, whose underlying mechanisms need to be examined further.
BdNub Is Essential for Maintaining gut Immunity and Microbiome Homeostasis in Bactrocera dorsalis
Authors: Gu Jian , Zhang Ping , Yao Zhichao , Li Xiaoxue , Zhang Hongyu
Published: February 2023

Insects face immune challenges posed by invading and indigenous bacteria. They rely on the immune system to clear these microorganisms. However, the immune response can be harmful to the host. Therefore, fine-tuning the immune response to maintain tissue homeostasis is of great importance to the survival of insects. The Nub gene of the OCT/POU family regulates the intestinal IMD pathway. However, the role of the Nub gene in regulating host microbiota remains unstudied. Here, a combination of bioinformatic tools, RNA interference, and qPCR methods were adopted to study BdNub gene function in Bactrocera dorsalis gut immune system. It’s found that BdNubX1, BdNubX2, and antimicrobial peptides (AMPs), including Diptcin (Dpt), Cecropin (Cec), AttcinA (Att A), AttcinB (Att B) and AttcinC (Att C) are significantly up-regulated in Tephritidae fruit fly Bactrocera dorsalis after gut infection. Silencing BdNubX1 leads to down-regulated AMPs expression, while BdNubX2 RNAi leads to increased expression of AMPs. These results indicate that BdNubX1 is a positive regulatory gene of the IMD pathway, while BdNubX2 negatively regulates IMD pathway activity. Further studies also revealed that BdNubX1 and BdNubX2 are associated with gut microbiota composition, possibly through regulation of IMD pathway activity. Our results prove that the Nub gene is evolutionarily conserved and participates in maintaining gut microbiota homeostasis.
Robust Control and Active Vibration Suppression in Dynamics of Smart Systems
Authors: Moutsopoulou Amalia , Stavroulakis Georgios E. , Pouliezos Anastasios , Petousis Markos , Vidakis Nectarios
Published: February 2023

Challenging issues arise in the design of control strategies for piezoelectric smart structures. Piezoelectric materials have been investigated for use in distributed parameter systems in order to provide active control efficiently and affordably. In the active control of dynamic systems, distributed sensors and actuators can be created using piezoelectric materials. The three fundamental issues that structural control engineers must face when creating robust control laws are structural modeling methodologies, uncertainty modeling, and robustness validation. These issues are reviewed in this article. A smart structure with piezoelectric (PZT) materials is investigated for its active vibration response under dynamic disturbance. Numerical modeling with finite elements is used to achieve that. The vibration for different model values is presented considering the uncertainty of the modeling. A vibration suppression was achieved with a robust controller and with a reduced order controller. Results are presented for the frequency domain and the state space domain. This work cleary demostrated the advantage of robust control in the vibration suppration of smart stuctures.
Effectiveness and Safety of Mitral Valve Plasty in Patients with an Anomalous Origin of the Coronary Artery from the Pulmonary Artery
Authors: Lv Lizhi , Lang Xinyue , Zhang Simeng , Wang Cheng , Jin Yuanhao , Zhi Aihua , Wang Qiang
Published: February 2023

The study aimed to determine the effectiveness and safety of anomalous coronary artery from pulmonary artery (ACAPA) patients with moderate or severe mitral valve regurgitation (MVR) receiving mitral valve plasty (MVP) concurrently. Consecutive ACAPA patients undergoing surgery between 2015 and 2021 were retrospectively included. Patients were divided into three groups: moderate MVR without MVP (non-MVP (moderate) N = 14), moderate MVR with MVP (MVP (moderate) N = 13), and severe MVR with MVP (MVP (severe) N = 13). The primary safety endpoint was in-hospital surgery-related complications. The primary effectiveness outcome was left ventricular ejection function (LVEF) and left ventricular end-diastolic diameter (LVEDD) z-score at 2- and 24-month follow-ups. Multivariable linear regression models were used to obtain the β coefficient. The median age of the included patients was 7.5 years (IQR 1.4–26.5). The in-hospital surgery-related complication rates were 7.1%, 15.4%, and 7.7% in non-MVP (moderate), MVP (moderate), and MVP (severe) groups, separately. At the 2-month follow-up, the non-MVP (moderate) group had a better LVEF and LVEDD z-score compared with the MVP (moderate) group (LVEF β = 9.22, 95%CI 1.09 to 17.35; LVEDD z-score β = −2.49, 95%CI −4.53 to −0.45). At the 24-month follow-up, the LVEF of all patients and the LVEDD z-score of 90% of patients in the three groups returned to normal. For ACAPA patients with moderate MVR, MVP was not necessary, especially for pediatric patients (age < 3 years) and patients with secondary MVR. Further studies for ACAPA patients with severe MVR are still needed.
Frequency of Smoking and Marginal Bone Loss around Dental Implants: A Retrospective Matched-Control Study
Authors: Ali Amir , Al Attar Ammar , Chrcanovic Bruno Ramos
Published: February 2023

This dental record-based retrospective study aimed to compare the marginal bone loss (MBL) around dental implants in a group of smokers in relation to a matched group of non-smokers, with a special focus on five different frequencies of daily smoking (non-smokers, and frequency of 1–5, 6–10, 11–15, and 20 cig./day). Only implants with a minimum of 36 months of radiological follow-up were considered. Univariate linear regression models were used to compare MBL over time between 12 clinical covariates, after which a linear mixed-effects model was built. After matching of the patients, the study included 340 implants in 104 smokers, and 337 implants in 100 non-smokers. The results suggested that smoking degree (greater MBL for higher degrees of smoking), bruxism (greater MBL for bruxers), jaw (greater MBL in maxilla), prosthesis fixation (greater MBL for screw-retained prosthesis), and implant diameter (greater MBL for 3.75–4.10 mm) had a significant influence on MBL over time. There appears to be a positive correlation between the degree of smoking and the degree of MBL, meaning, the higher the degree of smoking, the greater the MBL. However, the difference is not apparent for different degrees of smoking when this is high, namely above 10 cigarettes per day.
Influence of Lateral Translation of Lowest Instrumented Vertebra on L4 Tilt and Coronal Balance for Thoracolumbar and Lumbar Curves in Adolescent Idiopathic Scoliosis
Authors: Yamada Katsuhisa , Sudo Hideki , Abe Yuichiro , Kokabu Terufumi , Tachi Hiroyuki , Endo Tsutomu , Ohnishi Takashi , Ukeba Daisuke , Ura Katsuro , Takahata Masahiko , Iwasaki Norimasa
Published: February 2023

This study aimed to evaluate the lowest instrumented vertebra translation (LIV-T) in the surgical treatment of thoracolumbar/lumbar adolescent idiopathic scoliosis and to analyze the radiographic parameters in relation to LIV-T and L4 tilt and global coronal balance. A total of 62 patients underwent posterior spinal fusion (PSF, n = 32) or anterior spinal fusion (ASF, n = 30) and were followed up for a minimum of 2 years. The mean preoperative LIV-T was significantly larger in the ASF group than the PSF (p < 0.01), while the final LIV-T was equivalent. LIV-T at the final follow-up was significantly correlated with L4 tilt and the global coronal balance (r = 0.69, p < 0.01, r = 0.38, p < 0.01, respectively). Receiver-operating characteristic analysis for good outcomes, with L4 tilt <8° and coronal balance <15 mm at the final follow-up, calculated the cutoff value of the final LIV-T as 12 mm. The cutoff value of preoperative LIV-T that would result in the LIV-T of ≤12 mm at the final follow-up was 32 mm in PSF, although no significant cutoff value was calculated in ASF. ASF can centralize the LIV better than PSF with a shorter segment fusion, and could be useful in obtaining a good curve correction and global balance without fixation to L4 in cases with large preoperative LIV-T.
Efficacy of Guided Tissue Regeneration Using Frozen Radiation-Sterilized Allogenic Bone Graft as Bone Replacement Graft Compared with Deproteinized Bovine Bone Mineral in the Treatment of Periodontal Intra-Bony Defects: Randomized Controlled Trial
Authors: Brodzikowska Aniela , Górski Bartłomiej , Szerszeń Marcin , Sanz Mariano
Published: February 2023

(1) Background: The aim of this study was to compare the clinical and radiographic outcomes of guided tissue regeneration (GTR) using two biomaterials as bone replacement grafts in the treatment of periodontal intra-bony defects. (2) Methods: Using a split-mouth design, 30 periodontal intra-bony defects were treated with either frozen radiation-sterilized allogenic bone grafts (FRSABG tests) or deproteinized bovine bone mineral (DBBM, controls) combined with a bioabsorbable collagen membrane in 15 patients. Clinical attachment level gains (CAL-G), probing pocket depth reductions (PPD-R), and radiographic changes in linear defect fill (LDF) were evaluated 12 months postoperatively. (3) Results: The CAL, PPD, and LDF values improved significantly in both groups 12 months after the surgery. However, in the test group, the PPD-R and LDF values were significantly higher compared to the controls (PPD-R 4.66 mm versus 3.57 mm, p = 0.0429; LDF 5.22 mm versus 4.33, p = 0.0478, respectively). Regression analysis showed that baseline CAL was a significant predictor for PPD-R (p = 0.0434), while the baseline radiographic angle was a predictor for CAL-G (p = 0.0026) and LDF (p = 0.064). (4) Conclusions: Both replacement grafts when used for GTR with a bioabsorbable collagen membrane yielded successful clinical benefits in teeth with deep intra-bony defects 12 months postoperatively. The use of FRSABG significantly enhanced PPD reduction and LDF.
Osteopontin and Regulatory T Cells in Effector Phase of Allergic Contact Dermatitis
Authors: Reduta Teresa , Bacharewicz-Szczerbicka Joanna , Stasiak-Barmuta Anna , Kaminski Tomasz W. , Flisiak Iwona
Published: February 2023

Studies have shown that osteopontin (OPN) and regulatory T cells play a role in allergic contact dermatitis (ACD), but the mechanisms responsible for their function are poorly understood. The study aimed to determine CD4 T lymphocytes producing intracellular osteopontin (iOPN T cells) and assess the selected T lymphocyte subsets including regulatory T cells in the blood of patients with ACD. Twenty-six patients with a disseminated form of allergic contact dermatitis and 21 healthy controls were enrolled in the study. Blood samples were taken twice: in the acute phase of the disease and during remission. The samples were analyzed by the flow cytometry method. Patients with acute ACD showed significantly higher percentage of iOPN T cells compared with healthy controls which persisted during remission. An increase in the percentage of CD4CD25 and a reduced percentage of regulatory T lymphocytes (CD4CD25highCD127low) were also found in the patients with acute stage of ACD. The percentage of CD4CD25 T lymphocytes showed a positive correlation with the EASI index. The increase in the iOPN T cells can indicate their participation in acute ACD. The decreased percentage of regulatory T lymphocytes in the acute stage of ACD may be related to the transformation of Tregs into CD4CD25 T cells. It may also indicate their increased recruitment to the skin. The positive correlation between the percentage of CD4CD25 lymphocytes and the EASI index may be indirect evidence for the importance of activated lymphocytes—CD4CD25 in addition to CD8 lymphocytes as effector cells in ACD.
Infectious Pneumonia and Lung Ultrasound: A Review
Authors: Boccatonda Andrea , Cocco Giulio , D’Ardes Damiano , Delli Pizzi Andrea , Vidili Gianpaolo , De Molo Chiara , Vicari Susanna , Serra Carla , Cipollone Francesco , Schiavone Cosima , Guagnano Maria
Published: February 2023

The application of thoracic ultrasound examination has not long been developed because ultrasound’s interaction with the lung does not generate an anatomical image but an artifactual one. Subsequently, the evaluation of pulmonary artifacts and their correlation to specific diseases allowed the development of ultrasound semantics. Currently, pneumonia still represents one of the main causes of hospitalization and mortality. Several studies in the literature have demonstrated the ultrasound features of pneumonia. Although ultrasound cannot be considered the diagnostic gold standard for the study of all lung diseases, it has experienced an extraordinary development and growth of interest due to the SARS-CoV-2 pandemic. This review aims to provide essential information on the application of lung ultrasound to the study of infectious pneumonia and to discuss the differential diagnosis.
Correction: Osterwalder et al. Acute Abdominal Pain: Missed Diagnoses, Extra-Abdominal Conditions, and Outcomes. J. Clin. Med. 2020, 9, 899
Authors: Osterwalder Isabelle , Özkan Merve , Malinovska Alexandra , Nickel Christian H. , Bingisser Roland
Published: February 2023

In the original publication [...]
Observations for Sjögren’s Pigment Epithelial Reticular Dystrophy in a 16-Year-Old Boy—An Extremely Rare Retinal Case Report
Authors: Modrzejewska Monika , Lubiński Wojciech , Czyżewska Katarzyna , Bosy-Gąsior Wiktoria
Published: February 2023

The purpose of this publication is to present an extremely rare case of Sjögren’s pigment epithelial reticular dystrophy. So far, 10 such publications have been found in world literature. A 16-year-old boy was diagnosed due to a slight loss of visual acuity, confirmed in static perimetry/24-2/. Abnormal dense clusters of retinal pigment epithelium (RPE) cells forming a reticular network pattern (resembling a fishing net) with marked knots were detected by fundoscopy in the macular area and the mid-periphery of the retina. No abnormalities were found in the anterior segment, intraocular pressure, kinetic perimetry, Ishihara or Farnsworth D-15 tests or OCT. Fluorescein angiography confirmed blocked fluorescence from the choroidal vessels caused by the pigment in RPE. An autofluorescence test showed hypofluorescent foci corresponding to symmetrical and bilateral retinal hyperpigmentation with an RPE reticular pattern. Multifocal ERG (mfERG) revealed slight cone photoreceptor and bipolar bioelectrical dysfunction. Electrooculography (EOG) showed significant asymmetry (Arden Ratio 1.8), suggesting bioelectrical dysfunction of RPE/photoreceptors. Flash ERG (ERG) revealed only slight increase in implicit time of the a and b waves of the rod and cone responses and exclude cone-rod dystrophies. This article highlights the importance of the results of ophthalmoscopy, fluorescein angiography, autofluorescence, mfERG, fERG, EOG and genetic tests for Sjögren’s reticular dystrophy with a pathogenic variant in the region of the C2 gene-c.841_849+19del (dbSNP rs9332736).
Dynamic Changes in Fluid Temperatures during Laser Irradiation Using Various Laser Modes: A Thermography-Based In Vitro Phantom Study
Authors: Yamashita Shimpei , Inoue Takaaki , Imai Satoshi , Maruyama Yohei , Iwahashi Yuya , Deguchi Ryusuke , Kohjimoto Yasuo , Fujisawa Masato , Hara Isao
Published: February 2023

The differences in dynamic thermal changes during laser lithotripsy between various laser pulse modes are unclear. We used thermography to evaluate the temporal changes in high-temperature areas during laser activation in order to compare different laser pulse modes. An unroofed artificial kidney model was used for the experiments. The laser fired for 60 s with a laser setting of 0.4 J/60 Hz in the following four different laser pulse modes without saline irrigation: short pulse mode (SPM), long pulse mode (LPM), virtual basket mode (VBM) and Moses mode (MM). Using the first 30 s of moving images, we compared the ratio of a high-temperature area of >43 °C to the total area every 5 seconds. The dynamic changes in fluid temperatures were shown to be different between the laser pulse modes. The extent of the high-temperature areas during the laser activation was large in the LPM and MM compared with the SPM and VBM. While the high-temperature areas expanded in an anterior direction in the early laser irradiation period using the LPM, they spread in a posterior direction in the early laser activation period using the MM. Although only the temperature profile in one specific plane was investigated, these results are considered useful for preventing thermal injuries during retrograde intrarenal surgeries.
Opioid-Sparing Effect of Multi-Point Incision-Based Rectus Sheath Block in Laparoscopic-Assisted Radical Gastrectomy: A Randomized Clinical Trial
Authors: Shi De-Wen , Zhou Xiao-Dan , Wang Feng-Jie , Wang Jing , Liu Yang , Niu Yong , Xu Guang-Hong
Published: February 2023

Background: Profound trauma from laparoscopic-assisted gastrectomy (LAG) requires medication with a large number of opioids. The purpose of our study was to observe whether an incision-based rectus sheath block (IBRSB) based on the locations of the surgical incision could significantly reduce the consumption of remifentanil during LAG. Methods: A total of 76 patients were included. The patients were prospectively randomized into two groups. Patients in group IBRSB (n = 38) received ultrasound-guided IBRSB, and the patients received 0.4% ropivacaine 40–50 mL. Patients in group C (n = 38) received the same IBRSB with 40–50 mL normal saline. The following were recorded: the consumption of remifentanil and sufentanil during surgery, pain scores at rest and during conscious activity in the post-anesthesia care unit (PACU) and at 6, 12, 24, and 48 h after surgery, and use of the patient-controlled analgesia (PCA) at 24 and 48 h after surgery. Results: A total of 60 participants completed the trial. The consumption of remifentanil and sufentanil in group IBRSB were significantly lower than that in group C (p < 0.001). Pain scores at rest and during conscious activity in the PACU and at 6, 12, 24, and 48 h after surgery and patients’ PCA consumption within 48 h of surgery were significantly lower in group IBRSB than in group C (all p < 0.05). Conclusions: IBRSB based on incision multimodal anesthesia can effectively reduce the consumption of opioids during LAG, improving the postoperative analgesic effect and increasing patients’ satisfaction.
Medication-Related Osteonecrosis of the Jaws (MRONJ) in Children and Young Patients—A Systematic Review
Authors: Rosales Hemil Dario , Garcia Guevara Henry , Requejo Stefania , Jensen Maria Dianella , Acero Julio , Olate Sergio
Published: February 2023

Medication-related osteonecrosis of the jaw (MRONJ) is defined by the American Association of Oral and Maxillofacial Surgeons (AAOMS) as the presence of an exposed bone area in the maxillofacial region, present for more than eight weeks in patients treated with the use of antiresorptive or antiangiogenic agents, with no history of radiation or metastatic disease. Bisphosphonates (BF) and denosumab (DS) are widely used in adults for the management of patients with cancer and osteoporosis, and recently there has been an increase in their use in child and young patients for the management of disorders such as osteogenesis imperfecta (OI), glucocorticoid-induced osteoporosis, McCune-Albright syndrome (MAS), malignant hypercalcemia, and others. There are differences between case reports in adults compared to child and young patients related to the use of antiresorptive/antiangiogenic drugs and the development of MRONJ. The aim was to analyze the presence of MRONJ in children and young patients, and the relation with oral surgery. A systematic review, following the PRISMA search matrix based on the PICO question, was conducted in PubMed, Embase, ScienceDirect, Cochrane, Google Scholar, and manual search in high-impact journals between 1960 and 2022, publications in English or Spanish, including randomized and non-randomized clinical trials, prospective and retrospective cohort studies, cases and controls studies, and series and case reports. A total of 2792 articles were identified and 29 were included; all of them published between 2007 and 2022, identifying 1192 patients, 39.68% male and 36.24% female, aged 11.56 years old on average, using these drugs mainly for OI (60.15%); 4.21 years on average was the therapy time and 10.18 drug doses administered on average; oral surgery was observed in 216 subjects, reporting 14 cases of MRONJ. We concluded that there is a low presence of MRONJ in the child and youth population treated with antiresorptive drugs. Data collection is weak, and details of therapy are not clear in some cases. Deficiencies in protocols and pharmacological characterization were observed in most of the included articles.
Incidence Trend of Follicular Lymphoma in Taiwan Compared to Japan and Korea, 2001–2019
Authors: Chiu Liang-Chun , Lin Chih-Wen , Li Hung-Ju , Chen Jian-Han , Chuang Fu-Cheng , Lin Sheng-Fung , Chang Yu , Su Yu-Chieh
Published: February 2023

A continuous increase in follicular lymphoma has been observed in Taiwan, Japan, and South Korea over the last few decades. This study aimed to evaluate the difference in incidence trends of follicular lymphoma in Taiwan, Japan, and South Korea between 2001 and 2019. The data for the Taiwanese populations was obtained from the Taiwan Cancer Registry Database, and those for the Japanese and Korean population were retrieved from the Japan National Cancer Registry and some additional reports, both of which included population-based cancer registry data, from Japan and Korea. Follicular lymphoma accounted for 4231 cases from 2002–2019 in Taiwan, 3744 cases from 2001–2008 and 49,731 cases from 2014–2019 in Japan; and 1365 cases from 2001–2012 and 1244 cases from 2011–2016 in South Korea. The annual percentage change for each time period was 3.49% (95% confidence interval: 2.75–4.24%) in Taiwan, 12.66% (95% confidence interval [CI]: 9.59–15.81%) and 4.95% (95% CI: 2.14–7.84%) in Japan, and 5.72% (95% CI: 2.79–8.73%) and 7.93% (95% CI: −1.63–18.42%) in South Korea. Our study confirms that the increasing trends of follicular lymphoma incidence in Taiwan and Japan have been remarkable in recent years, especially the rapid increase in Japan between 2014 and 2019; however, there was no significant in-crease from 2011 to 2015 in South Korea.
Characterisation of Composite Materials for Wind Turbines Using Frequency Modulated Continuous Wave Sensing
Authors: Tang Wenshuo , Blanche Jamie , Mitchell Daniel , Harper Samuel , Flynn David
Published: February 2023

Wind turbine blades (WTBs) are critical sub-systems consisting of composite multi-layer material structures. WTB inspection is a complex and labour intensive process, and failure of it can lead to substantial energy and economic losses to asset owners. In this paper, we proposed a novel non-destructive evaluation method for blade composite materials, which employs Frequency Modulated Continuous Wave (FMCW) radar, robotics and machine learning (ML) analytics. We show that using FMCW raster scan data, our ML algorithms (SVM, BP, Decision Tree and Naïve Bayes) can distinguish different types of composite materials with accuracy of over 97.5%. The best performance is achieved by SVM algorithms, with 94.3% accuracy. Furthermore, the proposed method can also achieve solid results for detecting surface defect: interlaminar porosity with 80% accuracy overall. In particular, the SVM classifier shows highest accuracy of 92.5% to 98.9%. We also show the ability to detect air voids of 1mm differences within the composite material WT structure with 94.1% accuracy performance using SVM, and 84.5% using Naïve Bayes. Lastly, we create a digital twin of the physical composite sample to support the integration and qualitative analysis of the FMCW data with respect to composite sample characteristics. The proposed method explores a new sensing modality for non-contact surface and subsurface for composite materials, and offer insights for developing alternative, more cost-effective inspection and maintenance regimes.
3D-Printed GelMA/PEGDA/F127DA Scaffolds for Bone Regeneration
Authors: Gao Jianpeng , Li Ming , Cheng Junyao , Liu Xiao , Liu Zhongyang , Liu Jianheng , Tang Peifu
Published: February 2023

Tissue-engineered scaffolds are an effective method for the treatment of bone defects, and their structure and function are essential for bone regeneration. Digital light processing (DLP) printing technology has been widely used in bone tissue engineering (BTE) due to its high printing resolution and gentle printing process. As commonly used bioinks, synthetic polymers such as polyethylene glycol diacrylate (PEGDA) and Pluronic F127 diacrylate (F127DA) have satisfactory printability and mechanical properties but usually lack sufficient adhesion to cells and tissues. Here, a compound BTE scaffold based on PEGDA, F127DA, and gelatin methacrylate (GelMA) was successfully prepared using DLP printing technology. The scaffold not only facilitated the adhesion and proliferation of cells, but also effectively promoted the osteogenic differentiation of mesenchymal stem cells in an osteoinductive environment. Moreover, the bone tissue volume/total tissue volume (BV/TV) of the GelMA/PEGDA/F127DA (GPF) scaffold in vivo was 49.75 ± 8.50%, higher than the value of 37.10 ± 7.27% for the PEGDA/F127DA (PF) scaffold and 20.43 ± 2.08% for the blank group. Therefore, the GPF scaffold prepared using DLP printing technology provides a new approach to the treatment of bone defects.
Hydrodynamic Loads on a Group of Six Structures of Different Cross-Sections in Uniform and Sheared Flow
Authors: Annapeh Henry Francis , Kurushina Victoria
Published: February 2023

The estimates of hydrodynamic forces for a group of structures represent a challenge for the design of offshore systems, as they are subject to changes with a variation in flow profiles. The fluctuating effects may be more pronounced or, on the contrary, suppressed if the cross-sectional shape of structures in an array is altered. The present work performs a series of 2D numerical simulations for the flow past six identical stationary cylinders of three distinct geometrical shapes arranged in a 2 × 3 matrix configuration. The flow profiles considered have an averaged velocity corresponding to the critical flow regime of a Reynolds number of 2.5 × 105. The detached eddy simulation k–ω SST turbulence model is employed to perform a comprehensive investigation of the fluid force coefficients, their frequencies and vortex formation patterns. The effect of the spacing ratio varied simultaneously among the structures from 2 to 7 is considered in conjunction with the change in the flow profile and the cylinders’ cross-section. The results of simulations show a higher mean drag on the upstream cylinders, reduced mean drag on the mid- and downstream cylinders with the second cross-sectional shape, and a higher mean drag on the cylinders with the third cross-sectional shape, compared to the original circular cylinders.
Ecological Response to the Diluted Water in Guangxi during the Spring Monsoon Transition in 2021
Authors: Yang Yang , Yang Tinglong , Zhang Zhen , Zhu Zuhao , Zhang Li , Cheng Dewei
Published: February 2023

Based on the field survey data of the Guangxi offshore voyage in May 2021, the distribution characteristics of the wind field during the spring monsoon transition period, the temporal and spatial changes in the diluted water path, and the corresponding ecological responses were analyzed. The results show the following: the core region of diluted water is located along the coast of Guangxi, and the diluted water expands to the east and west at the same time, where the thickness of the diluted water reaches 20 m. Under the combined action of the easterly wind and westward current, the westward expansion trend was stronger than the eastward expansion trend. The surface distribution of suspended solids, chlorophyll a, dissolved oxygen, and active silicon is similar to the dispersion range of the diluted water, and the high-value areas all appear near the estuary, which is basically consistent with the salinity distribution in the core region of the diluted water. Under the mixing caused by the wind and tide in the estuary area, the difference in dissolved oxygen between the surface and bottom layer is small, while in the nearshore area, the stratification of seawater hinders the dissolved oxygen’s downward transmission, resulting in a large difference in dissolved oxygen between the bottom and the surface.
Investigation of the Spiral Wave Generation and Propagation on a Numerical Circular Wave Tank Model
Authors: Islam Mohammad Shaiful , Nakamura Tomoaki , Cho Yong-Hwan , Mizutani Norimi
Published: February 2023

A two-phase incompressible flow model in three-dimensional cylindrical coordinates is applied for oblique wave generation in a numerical circular wave tank. The governing equations are discretized by a finite volume method, and a mass source function is added to reproduce oblique waves through a spiral wave generator positioned at the center of the tank. The volume of fluid method is implemented to track the free surfaces between the air and fluid, and the zonal embedded grid system is adopted to obtain a grid-independent solution in the cylindrical coordinates. A permeable, circumferentially sloping topography (1:7), similar to a natural beach profile, is set up for investigating wave propagation and other characteristics. The simulation and physical experimental results are compared, which show a good agreement in randomly selected water surface elevation profiles and wave heights under the same wave and sloping conditions. The spiral waves are reproduced and propagated in a phenomenon similar to that observed in the physical experiment. The results also show that the wave-breaking positions differ in different wave conditions and suggest a relationship with cross-shore and longshore velocity distribution in terms of incident wave heights and wave-breaking positions in different wave periods on the same sloping topography. Furthermore, this model can be used to investigate the mechanism of longshore current generation and the influences of beach slope on the generated wave propagation in a sloping topography.
Persistence of Metarhizium brunneum (Ascomycota: Hypocreales) in the Soil Is Affected by Formulation Type as Shown by Strain-Specific DNA Markers
Authors: Hernández Iker , Sant Clara , Martínez Raquel , Almazán Marta , Caminal Marta , Quero Víctor , El-Adak Mohammed , Casanova Albert , Garrido-Jurado Inmaculada , Yousef-Yousef Meelad , Quesada-Moraga Enrique , Lara José Manuel , Fernández Carolina
Published: February 2023

The genus Metarhizium has an increasingly important role in the development of Integrated Pest Control against Tephritid fruit flies in aerial sprays targeting adults and soil treatments targeting preimaginals. Indeed, the soil is considered the main habitat and reservoir of Metarhizium spp., which may be a plant-beneficial microorganism due to its lifestyle as an endophyte and/or rhizosphere-competent fungus. This key role of Metarhizium spp. for eco-sustainable agriculture highlights the priority of developing proper monitoring tools not only to follow the presence of the fungus in the soil and to correlate it with its performance against Tephritid preimaginals but also for risk assessment studies for patenting and registering biocontrol strains. The present study aimed at understanding the population dynamics of M. brunneum strain EAMb 09/01-Su, which is a candidate strain for olive fruit fly Bactrocera oleae (Rossi, 1790) preimaginal control in the soil, when applied to the soil at the field using different formulations and propagules. For this, strain-specific DNA markers were developed and used to track the levels of EAMb 09/01-Su in the soil of 4 field trials. The fungus persists over 250 days in the soil, and the levels of the fungus remained higher when applied as an oil-dispersion formulation than when applied as a wettable powder or encapsulated microsclerotia. Peak concentrations of EAMb 09/01-Su depend on the exogenous input and weakly on environmental conditions. These results will help us to optimize the application patterns and perform accurate risk assessments during further development of this and other entomopathogenic fungus-based bioinsecticides.
Antifungal and Antibiofilm Activity of Riparin III against Dermatophytes
Authors: Silva Emanuel Pereira , Rocha Marcelo Antônio Nóbrega da , Silva Risley Nikael Medeiros , Moura-Mendes Juliana , Sousa Gabriela Ribeiro de , de Souza-Ferrari Jailton , Barbosa-Filho José Maria , Lima Edeltrudes de Oliveira , Pereira Fillipe de Oliveira
Published: February 2023

The ability of dermatophytes to develop biofilms is possibly involved in therapeutic failure because biofilms impair drug effectiveness in the infected tissues. Research to find new drugs with antibiofilm activity against dermatophytes is crucial. In this way, riparins, a class of alkaloids that contain an amide group, are promising antifungal compounds. In this study, we evaluated the antifungal and antibiofilm activity of riparin III (RIP3) against Trichophyton rubrum, Microsporum canis, and Nannizzia gypsea strains. We used ciclopirox (CPX) as a positive control. The effects of RIP3 on fungal growth were evaluated by the microdilution technique. The quantification of the biofilm biomass in vitro was assessed by crystal violet, and the biofilm viability was assessed by quantifying the CFU number. The ex vivo model was performed on human nail fragments, which were evaluated by visualization under light microscopy and by quantifying the CFU number (viability). Finally, we evaluated whether RIP3 inhibits sulfite production in T. rubrum. RIP3 inhibited the growth of T. rubrum and M. canis from 128 mg/L and N. gypsea from 256 mg/L. The results showed that RIP3 is a fungicide. Regarding antibiofilm activity, RIP3 inhibited biofilm formation and viability in vitro and ex vivo. Moreover, RIP3 inhibited the secretion of sulfite significantly and was more potent than CPX. In conclusion, the results indicate that RIP3 is a promising antifungal agent against biofilms of dermatophytes and might inhibit sulfite secretion, one relevant virulence factor.
Lack of Association between YEASTONE Antifungal Susceptibility Tests and Clinical Outcomes of Cryptococcus Meningitis
Authors: Wu Ting-Shu , Lin Jung-Fu , Cheng Chun-Wen , Huang Po-Yen , Yang Jeng-How
Published: February 2023

The relation between antifungal susceptibility and treatment outcomes is not well-characterized. There is paucity of surveillance data for cerebrospinal fluid (CSF) isolates of cryptococcus investigated with YEASTONE colorimetric broth microdilution susceptibility testing. A retrospective study of laboratory-confirmed cryptococcus meningitis (CM) patients was conducted. The antifungal susceptibility of CSF isolates was determined using YEASTONE colorimetric broth microdilution. Clinical parameters, CSF laboratory indices, and antifungal susceptibility results were analyzed to identify risk factors for mortality. High rates of resistance to fluconazole and flucytosine were observed in this cohort. Voriconazole had the lowest MIC (0.06 µg/mL) and lowest rate of resistance (3.8%). In a univariate analysis, hematological malignancy, concurrent cryptococcemia, high Sequential Organ Failure Assessment (SOFA) score, low Glasgow coma scale (GCS) score, low CSF glucose level, high CSF cryptococcal antigen titer, and high serum cryptococcal antigen burden were associated with mortality. In a multivariate analysis, meningitis with concurrent cryptococcemia, GCS score, and high CSF cryptococcus burden, were independent predictors of poor prognosis. Both early and late mortality rates were not significantly different between CM wild type and non-wild type species.