bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Catalytic Performance of Pd/CNFs for Hydrogen Evolution from Additive-Free Formic Acid Decomposition
Authors: Sanchez Felipe , Motta Davide , Bocelli Ludovica , Albonetti Stefania , Roldan Alberto , Hammond Ceri , Villa Alberto , Dimitratos Nikolaos
Published: May 2018

In recent years, research efforts have focused on the development of safe and efficient H2 generation/storage materials toward a fuel-cell-based H2 economy as a long-term solution in the near future. Herein, we report the development of Pd nanoparticles supported on carbon nanofibers (CNFs) via sol-immobilisation and impregnation techniques. Thorough characterisation has been carried out by means of XRD, XPS, SEM-EDX, TEM, and BET. The catalysts have been evaluated for the catalytic decomposition of formic acid (HCOOH), which has been identified as a safe and convenient H2 carrier under mild conditions. The influence of preparation method was investigated and catalysts prepared by the sol-immobilisation method showed higher catalytic performance (PdSI/CNF) than their analogues prepared by the impregnation method (PdIMP/CNF). A high turnover frequency (TOF) of 979 h−1 for PdSI/CNF and high selectivity (>99.99%) was obtained at 30 °C for the additive-free formic acid decomposition. Comparison with a Pd/AC (activated charcoal) catalyst synthesised with sol-immobilisation method using as a support activated charcoal (AC) showed an increase of catalytic activity by a factor of four, demonstrating the improved performance by choosing CNFs as the preferred choice of support for the deposition of preformed colloidal Pd nanoparticles.
Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation
Authors: Matsuda Satoru , Nakagawa Yukie , Kitagishi Yasuko , Nakanishi Atsuko , Murai Toshiyuki
Published: May 2018

Mesenchymal stromal/stem cells (MSCs) are multipotent cells that can differentiate to various specialized cells, which have the potential capacity to differentiate properly and accelerate recovery in damaged sites of the body. This stem cell technology has become the fundamental element in regenerative medicine. As reactive oxygen species (ROS) have been reported to adversely influence stem cell properties, it is imperative to attenuate the extent of ROS to the promising protective approach with MSCs’ regenerative therapy. Oxidative stress also affects the culture expansion and longevity of MSCs. Therefore, there is great need to identify a method to prevent oxidative stress and replicative senescence in MSCs. Phosphatase and tensin homologue deleted on chromosome 10/Protein kinase B, PKB (PTEN/AKT) and the tumor suppressor p53 pathway have been proven to play a pivotal role in regulating cell apoptosis by regulating the oxidative stress and/or ROS quenching. In this review, we summarize the current research and our view of how PTEN/AKT and p53 with their partners transduce signals downstream, and what the implications are for MSCs’ biology.
Lattice Correspondence and Growth Structures of Monoclinic Mg4Zn7 Phase Growing on an Icosahedral Quasicrystal
Authors: Singh Alok , Rosalie Julian M.
Published: May 2018

Mg 4 Zn 7 phase, with a monoclinic unit cell, a layered structure and a unique axis showing pseudo-tenfold symmetry, grows over icosahedral quasicrystalline phase in a manner similar to a decagonal quasicrystal. In this study, the relationship of this phase to icosahedral quasicrystal is brought out by a transmission electron microscopy study of Mg 4 Zn 7 phase growing on icosahedral phase in a cast Mg-Zn-Y alloy. Lattice correspondences between the two phases have been determined by electron diffraction. Planes related to icosahedral fivefold and pseudo-twofold symmetry are identified. Possible orthogonal cells bounded by twofold symmetry-related planes have been determined. Mg 4 Zn 7 phase growing on an icosahedral phase exhibits a number of planar faults parallel to the monoclinic axis, presumably to accommodate the quasiperiodicity at the interface. Two faults were identified, which were on {200} and { 2 ¯ 01} planes. Their structures have been determined by high resolution imaging in TEM. They produce two different unit cells at the interface.
The Enigmatic Weevil Genus Philetaerobius from Southern Africa: Definition, Affinities and Description of Three New Species (Coleoptera: Curculionidae: Entiminae)
Authors: Borovec Roman , Oberprieler Rolf G. , Meregalli Massimo
Published: May 2018

The small entimine genus Philetaerobius Marshall, 1923 is revised, entailing a redescription of the genus and the only hitherto described species, P. nidicola Marshall, as well as the description of three new species, P. endroedyi sp. n., P. garibebi sp. n. and P. louwi sp. n. A lectotype is designated for P. nidicola Marshall. The habitus and taxonomically important structures of all species are illustrated, including the previously unrecorded male and female genitalia. A key to the four species is provided, as well as a map of their known distributions in southern Namibia and the Northern and Western Cape provinces of South Africa. The habits of the genus, as known, are summarized, and its taxonomic position and indicated relationship with the taxonomically equally isolated genus Spartecerus are discussed. The habitus and genitalia of some Spartecerus species are also illustrated, and the available information on the life-history of the genus is summarized.
Epigenetic Regulation of ATP-Binding Cassette Protein A1 (ABCA1) Gene Expression: A New Era to Alleviate Atherosclerotic Cardiovascular Disease
Authors: Zaiou Mohamed , Bakillah Ahmed
Published: May 2018

The most important function of high density lipoprotein (HDL) is its ability to remove cholesterol from cells and tissues involved in the early stages of atherosclerosis back to the liver for excretion. The ATP-binding cassette transporters ABCA1 and ABCG1 are responsible for the major part of cholesterol efflux to HDL in macrophage foam cells. Thus, promoting the process of reverse cholesterol transport (RCT) by upregulating mainly ABCA1 remains one of the potential targets for the development of new therapeutic agents against atherosclerosis. Growing evidence suggests that posttranscriptional regulation of HDL biogenesis as well as modulation of ABCA1 expression are under the control of several genetic and epigenetic factors such as transcription factor (TFs), microRNAs (miRNAs) and RNA-binding proteins (RBPs).These factors may act either individually or in combination to orchestrate ABCA1 expression. Complementary to our recent work, we propose an exploratory model for the potential molecular mechanism(s) underlying epigenetic signature of ABCA1 gene regulation. Such a model may hopefully provide the basic framework for understanding the epigenetic regulation of RCT and contribute to the development of novel therapeutic strategies to alleviate the burden of cardiovascular diseases (CVD).
Transport Demand Management Policy Integration in Chinese Cities: A Proposed Analysis of Its Effects
Authors: Yang Wei , Veeneman Wijnand , De Jong Martin
Published: May 2018

Transport demand management (TDM) measures are widely regarded as essential tools to deal with traffic issues. Their effectiveness has been under scrutiny. Packaging of TDM measures has recently received much attention from researchers and governments because it can achieve more complex policy goals and resolve the negative effects of single TDM measures. Many studies have examined the concept of policy packaging, the ideal packaging process, and potential barriers at the theoretical level. However, the way TDM packaging as a concept works in a real-world context has received little attention. Additionally, there is little methodology to analyse its characteristics from a dynamic and historical perspective. Therefore, this study provides a methodology for analysing TDM packaging in four dimensions (i.e., density, classification, interaction, and time). These dimensions respectively reveal how many and what kind of TDM measures have been implemented, how they interact in a package, and how these characteristics change over time. We examine this methodology through comparative case studies based on policy document analysis in two Chinese cities, Dalian and Shenzhen, both of which adopt a large number of TDM measures. The results show that this methodology successfully reveals the characteristics of case cities: both tend to put more TDM measures into the transport policy package to deal with traffic issues, but the package in Shenzhen is more integrative than that in Dalian. We also find that with the integration of packaging increasing, transport systems are becoming more sustainable, and Shenzhen performs better in this regard than Dalian. This methodology can be used to analyse policy packaging in broader areas and to examine its influence on transport systems in more case studies in future research.
Automatic Assessment of Crown Projection Area on Single Trees and Stand-Level, Based on Three-Dimensional Point Clouds Derived from Terrestrial Laser-Scanning
Authors: Ritter Tim , Nothdurft Arne
Published: May 2018

Crown projection area (CPA) is a critical parameter in assessing inter-tree competition and estimating biomass volume. A multi-layer seeded region growing-based approach to the fully automated assessment of CPA based on 3D-point-clouds derived from terrestrial laser scanning (TLS) is presented. Independently repeated manual CPA-measurements in a subset of the stand serve as the reference and enable quantification of the inter-observer bias. Allometric models are used to predict CPA for the whole stand and are compared to the TLS-based estimates on the single tree- and stand-level. It is shown that for single trees, the deviation between CPA measurements derived from TLS data and manual measurements is on par with the deviations between manual measurements by different observers. The inter-observer bias propagates into the allometric models, resulting in a high uncertainty of the derived estimates at tree-level. Comparing the allometric models to the TLS measurements at stand-level reveals the high influence of crown morphology, which only can be taken into account by the TLS measurements and not by the allometric models.
The Challenge of Diffusion in Forest Plans: A Methodological Proposal and Case Study
Authors: Bruña-García Xabier , Marey-Pérez Manuel F.
Published: May 2018

Society’s participation in decisions regarding land planning and management is essential for reaching viable and long-lasting solutions. The success of forest plans depends on the involvement of different stakeholders. In turn, stakeholder involvement depends on the representativity achieved in public participation in the development of the plan. The first stage, diffusion, is the key element in the process. This paper describes a methodology for the diffusion stage that obtains six times more participants than a similar process. Its aim is to achieve stakeholder representativity in the forestry sector in forest planning at a subregional level. The methodology is validated and applied in a municipality of Galicia, north-west Spain. It is evaluated in terms of efficiency considering the effort in each stage and the results achieved.
MinHash-Based Fuzzy Keyword Search of Encrypted Data across Multiple Cloud Servers
Authors: He Jingsha , Wu Jianan , Zhu Nafei , Pathan Muhammad Salman
Published: May 2018

To enhance the efficiency of data searching, most data owners store their data files in different cloud servers in the form of cipher-text. Thus, efficient search using fuzzy keywords becomes a critical issue in such a cloud computing environment. This paper proposes a method that aims at improving the efficiency of cipher-text retrieval and lowering storage overhead for fuzzy keyword search. In contrast to traditional approaches, the proposed method can reduce the complexity of Min-Hash-based fuzzy keyword search by using Min-Hash fingerprints to avoid the need to construct the fuzzy keyword set. The method will utilize Jaccard similarity to rank the results of retrieval, thus reducing the amount of calculation for similarity and saving a lot of time and space overhead. The method will also take consideration of multiple user queries through re-encryption technology and update user permissions dynamically. Security analysis demonstrates that the method can provide better privacy preservation and experimental results show that efficiency of cipher-text using the proposed method can improve the retrieval time and lower storage overhead as well.
Expression Analysis of Cell Wall-Related Genes in Cannabis sativa: The “Ins and Outs” of Hemp Stem Tissue Development
Authors: Behr Marc , Lutts Stanley , Hausman Jean-Francois , Guerriero Gea
Published: May 2018

Textile hemp (Cannabis sativa L.) is a multipurpose crop producing biomass with uses in e.g., the textile, biocomposite, and construction sectors. It was previously shown that the hypocotyl of hemp is useful to study the kinetics of secondary tissue development, where primary and secondary growths are temporally uncoupled. We here sought to demonstrate that the stem of adult hemp plants is an additional suitable model to study the heterogeneous lignification of the tissues and the mechanisms underlying secondary cell wall formation in bast fibres. A targeted quantitative PCR analysis carried out on a set of twenty genes involved in cell wall biosynthesis clearly showed differences in expression in the core and cortical tissues along four stem regions spanning from elongation to cell wall thickening. Genes involved in phenylpropanoid biosynthesis and secondary cell wall cellulose synthases were expressed at higher levels in core tissues at the bottom, while specific genes, notably a class III peroxidase and a gene partaking in lignan biosynthesis, were highly expressed in the cortex of elongating internodes. The two systems, the hypocotyl and the adult stem of textile hemp, are equally valid and complementary to address questions related to lignification and secondary cell wall deposition.
Conceptualizing Ecological Flammability: An Experimental Test of Three Frameworks Using Various Types and Loads of Surface Fuels
Authors: Prior Lynda , Murphy Brett , Bowman David
Published: May 2018

Vegetation flammability remains poorly defined and involves many intercorrelated components and metrics. Schwilk (2015) proposed a flammability framework with only two axes: total heat release and rate of spread. Pausas et al. (2017) modified this framework by standardizing the heat release axis by fuel load, and adding a third axis of fuel ignitability. We tested these frameworks using data from a field experiment that quantified flammability metrics and survival of Callitris intratropica saplings in relation to fuel type (grass, litter, and mixed grass and litter, all air-dried) and fuel load. Principal components analysis showed PC1 was closely aligned with rate of combustion, flame height and temperature, and PC2 was aligned with duration of combustion. The Schwilk framework separated the fuel types according to rate of spread, and fuel loads according to total heat release. The Pausas framework was less useful in describing community-scale flammability because it removed the effects of fuel load, and there was no support for adding the ignitability axis. Both frameworks successfully predicted sapling mortality, an indicator of fire severity. In addition, the three flammability strategies proposed by Pausas et al. were not well-supported because they assumed unrealistically low heat release by ‘fast-flammable’ fuels. We conclude that the Schwilk framework is useful for conceptualizing community-scale flammability and facilitates modelling for fire management purposes, and exploration of evolutionary relationships.
Thermal Fluid Analysis of Cold Plasma Methane Reformer
Authors: Sobhansarbandi Sarvenaz , Maharjan Lizon , Fahimi Babak , Hassanipour Fatemeh
Published: May 2018

One of the most important methods of methane utilization is the conversion to synthesis gas (syngas). However, conventional ways of reforming methane usually require very high temperature, therefore non-thermal (non-equilibrium) plasma methane reforming is an attractive alternative. In this study, a novel plasma based reformer named 3D Gliding Arc Vortex Reformer (3D-GAVR) was investigated for partial oxidation of methane to produce syngas. The tangential input creates a vortex in the plasma zone and an expanded plasma presides within the entire area between the two electrodes. Using this method, the experimental results show that hydrogen can be produced for as low as $ 4.45 per kg with flow rates of around 1 L per minute. The maximum methane conversion percentage which is achieved by this technology is up to 62.38%. In addition, a computational fluid dynamics (CFD) modeling is conducted for a cold plasma reformer chamber named reverse vortex flow gliding arc reactor (RVF-GA) to investigate the effects of geometry and configuration on the reformer performance. In this modified reformer, an axial air input port is added to the top of the reaction vessel while the premixed reactants can enter the cylindrical reaction zone through tangential jets. The CFD results show that a reverse vortex flow (RVF) scheme can be created which has an outer swirling rotation along with a low pressure area at its center with some component of axial flow. The reversed vortex flow utilizes the uniform temperature and heat flux distribution inside the cylinder, and enhances the gas mixtures leading to expedition of the chemical reaction and the rate of hydrogen production.
Effects of the Swiss Franc/Euro Exchange Rate Floor on the Calibration of Probability Forecasts
Authors: Deaton Brian
Published: May 2018

Probability forecasts of the Swiss franc/euro (CHF/EUR) exchange rate are generated before, surrounding and after the placement of a floor on the CHF/EUR by the Swiss National Bank (SNB). The goal is to determine whether the exchange rate floor has a positive, negative or insignificant effect on the calibration of the probability forecasts from three time-series models: a vector autoregression (VAR) model, a VAR model augmented with the LiNGAM causal learning algorithm, and a univariate autoregressive model built on the independent components (ICs) of an independent component analysis (ICA). Score metric rankings of forecasts and plots of calibration functions are used in an attempt to identify the preferred time-series model based on forecast performance. The study not only finds evidence that the floor on the CHF/EUR has a negative impact on the forecasting performance of all three time-series models but also that the policy change by the SNB altered the causal structure underlying the six major currencies.
Lyapunov Characterization of the Fractional Nonlinear Systems with Exogenous Input
Authors: Sene Ndolane
Published: May 2018

This paper deals with a Lyapunov characterization of the conditional Mittag-Leffler stability and conditional asymptotic stability of the fractional nonlinear systems with exogenous input. A particular class of the fractional nonlinear systems is studied. The paper contributes to giving in particular the Lyapunov characterization of fractional linear systems and fractional bilinear systems with exogenous input.
Hydrodynamical Simulations of Recollimation Shocks within Relativistic Astrophysical Jets
Authors: Kaye Christopher , Cawthorne Timothy , Hughes Philip
Published: May 2018

Astrophysical jets launched from active galactic nuclei can remain tightly collimated over large distances due, in part, to recollimation shocks. Formed within the jets due to their supersonic nature, recollimation shocks are predicted to leave signatures in the observed radio emission due to magnetic flux freezing and the geometric relationship between magnetic fields and the polarization of synchrotron radiation. In the course of this work, we will compare how predictions of emission from recollimation shocks change when the flow is modelled using a hydrodynamical code, as opposed to semi-dynamical and magnetohydrodynamical codes. Jets generally exhibit low levels of polarization, which implies a substantially disordered magnetic field. It is difficult to model such fields using magnetohydrodynamics, hence this work uses hydrodynamical code and a statistical treatment of the magnetic field (c.f. Scheuer and Matthews, 1990). It should then be possible to assess whether certain radio jet phenomena, such as knots and radio-cores, may be modelled as singular or multiple recollimation shocks. To date, the hydrodynamical code has been successfully built and executed on UCLan’s supercomputer cluster, and parallelepiped vector triads have been included to monitor the fluid deformation within the simulation, so that the emergent flux and polarization may be calculated. The parallelepiped advection is currently being verified and some results are discussed. Code for radiative transfer throughout the jet is also being implemented, in order to simulate images for comparison with previous works and observations.
Low Maternal Microbiota Sharing across Gut, Breast Milk and Vagina, as Revealed by 16S rRNA Gene and Reduced Metagenomic Sequencing
Authors: Avershina Ekaterina , Angell Inga Leena , Simpson Melanie , Storrø Ola , Øien Torbjørn , Johnsen Roar , Rudi Knut
Published: May 2018

The maternal microbiota plays an important role in infant gut colonization. In this work we have investigated which bacterial species are shared across the breast milk, vaginal and stool microbiotas of 109 women shortly before and after giving birth using 16S rRNA gene sequencing and a novel reduced metagenomic sequencing (RMS) approach in a subgroup of 16 women. All the species predicted by the 16S rRNA gene sequencing were also detected by RMS analysis and there was good correspondence between their relative abundances estimated by both approaches. Both approaches also demonstrate a low level of maternal microbiota sharing across the population and RMS analysis identified only two species common to most women and in all sample types (Bifidobacterium longum and Enterococcus faecalis). Breast milk was the only sample type that had significantly higher intra- than inter- individual similarity towards both vaginal and stool samples. We also searched our RMS dataset against an in silico generated reference database derived from bacterial isolates in the Human Microbiome Project. The use of this reference-based search enabled further separation of Bifidobacterium longum into Bifidobacterium longum ssp. longum and Bifidobacterium longum ssp. infantis. We also detected the Lactobacillus rhamnosus GG strain, which was used as a probiotic supplement by some women, demonstrating the potential of RMS approach for deeper taxonomic delineation and estimation.
Female Choice Undermines the Emergence of Strong Sexual Isolation between Locally Adapted Populations of Atlantic Mollies (Poecilia mexicana)
Authors: Zimmer Claudia , Riesch Rüdiger , Jourdan Jonas , Bierbach David , Arias-Rodriguez Lenin , Plath Martin
Published: May 2018

Divergent selection between ecologically dissimilar habitats promotes local adaptation, which can lead to reproductive isolation (RI). Populations in the Poecilia mexicana species complex have independently adapted to toxic hydrogen sulfide and show varying degrees of RI. Here, we examined the variation in the mate choice component of prezygotic RI. Mate choice tests across drainages (with stimulus males from another drainage) suggest that specific features of the males coupled with a general female preference for yellow color patterns explain the observed variation. Analyses of male body coloration identified the intensity of yellow fin coloration as a strong candidate to explain this pattern, and common-garden rearing suggested heritable population differences. Male sexual ornamentation apparently evolved differently across sulfide-adapted populations, for example because of differences in natural counterselection via predation. The ubiquitous preference for yellow color ornaments in poeciliid females likely undermines the emergence of strong RI, as female discrimination in favor of own males becomes weaker when yellow fin coloration in the respective sulfide ecotype increases. Our study illustrates the complexity of the (partly non-parallel) pathways to divergence among replicated ecological gradients. We suggest that future work should identify the genomic loci involved in the pattern reported here, making use of the increasing genomic and transcriptomic datasets available for our study system.
Estimation of Nitrate Trends in the Groundwater of the Zagreb Aquifer
Authors: Kovač Zoran , Nakić Zoran , Špoljarić Drago , Stanek David , Bačani Andrea
Published: May 2018

Nitrates present one of the main groundwater contaminants in the world and in the Zagreb aquifer. The Zagreb aquifer presents the main source of potable water for the inhabitants of the City of Zagreb and it is protected by the Republic of Croatia. The determination of contaminants trends presents one of the main tools in groundwater body status and risk assessment. In this paper, the use of regression analysis on the aggregated data, together with confidence and prediction intervals, at different observation scales has been evaluated. Nitrate concentrations are generally decreasing in almost all areas, observed at different observation scales. It has been shown that linear regression can be efficiently used in the estimation of nitrates trends. Results showed that the calculation of confidence and prediction intervals can provide more useful conclusions than the calculation of the trend’s statistical significance. Also, the results suggest that confidence and prediction intervals can be used in groundwater body chemical status and risk assessment, respectively. Data smoothing and data aggregation are generally desirable, but have certain limitations. If too much data is aggregated, trend estimation by regression analysis can point to false conclusions. Evaluation of trends at different observational scales can provide more realistic trend estimation, as well as more precise identification of areas where groundwater protection measures should be implemented.
Weight Shame, Social Connection, and Depressive Symptoms in Late Adolescence
Authors: Brewis Alexandra A. , Bruening Meg
Published: May 2018

Child and adolescent obesity is increasingly the focus of interventions, because it predicts serious disease morbidity later in life. However, social environments that permit weight-related stigma and body shame may make weight control and loss more difficult. Rarely do youth obesity interventions address these complexities. Drawing on repeated measures in a large sample (N = 1443) of first-year (freshman), campus-resident university students across a nine-month period, we model how weight-related shame predicts depressive symptom levels, how being overweight (assessed by anthropometric measures) shapes that risk, and how social connection (openness to friendship) might mediate/moderate. Body shame directly, clearly, and repeatedly predicts depression symptom levels across the whole school year for all students, but overweight youth have significantly elevated risk. Social connections mediate earlier in the school year, and in all phases moderate, body shame effects on depression. Youth obesity interventions would be well-served recognizing and incorporating the influential roles of social-environmental factors like weight stigma and friendship in program design.
Antibiotic-Resistant Pathogenic Escherichia Coli Isolated from Rooftop Rainwater-Harvesting Tanks in the Eastern Cape, South Africa
Authors: Malema Mokaba , Abia Akebe , Tandlich Roman , Zuma Bonga , Mwenge Kahinda Jean-Marc , Ubomba-Jaswa Eunice
Published: May 2018

Although many developing countries use harvested rainwater (HRW) for drinking and other household purposes, its quality is seldom monitored. Continuous assessment of the microbial quality of HRW would ensure the safety of users of such water. The current study investigated the prevalence of pathogenic Escherichia coli strains and their antimicrobial resistance patterns in HRW tanks in the Eastern Cape, South Africa. Rainwater samples were collected weekly between June and September 2016 from 11 tanks in various areas of the province. Enumeration of E. coli was performed using the Colilert®18/Quanti-Tray® 2000 method. E. coli isolates were obtained and screened for their virulence potentials using polymerase chain reaction (PCR), and subsequently tested for antibiotic resistance using the disc-diffusion method against 11 antibiotics. The pathotype most detected was the neonatal meningitis E. coli (NMEC) (ibeA 28%) while pathotype enteroaggregative E. coli (EAEC) was not detected. The highest resistance of the E. coli isolates was observed against Cephalothin (76%). All tested pathotypes were susceptible to Gentamicin, and 52% demonstrated multiple-antibiotic resistance (MAR). The results of the current study are of public health concern since the use of untreated harvested rainwater for potable purposes may pose a risk of transmission of pathogenic and antimicrobial-resistant E. coli.
Evaluation of a Digital Consultation and Self-Care Advice Tool in Primary Care: A Multi-Methods Study
Authors: Cowie Julie , Calveley Eileen , Bowers Gillian , Bowers John
Published: May 2018

Digital services are often regarded as a solution to the growing demands on primary care services. Provision of a tool offering advice to support self-management as well as the ability to digitally consult with a General Practitioner (GP) has the potential to alleviate some of the pressure on primary care. This paper reports on a Phase II, 6-month evaluation of eConsult, a web-based triage and consultation system that was piloted across 11 GP practices across Scotland. Through a multi-method approach the evaluation explored eConsult use across practices, exposing both barriers and facilitators to its adoption. Findings suggest that expectations that eConsult would offer an additional and alternative method of accessing GP services were largely met. However, there is less certainty that it has fulfilled expectations of promoting self-help. In addition, low uptake meant that evaluation of current effectiveness was difficult for practices to quantify. The presence of an eConsult champion(s) within the practice was seen to be a significant factor in ensuring successful integration of the tool. A lack of patient and staff engagement, insufficient support and lack of protocols around processes were seen as barriers to its success.
Neighbourhood Built Environment Influences on Physical Activity among Adults: A Systematized Review of Qualitative Evidence
Authors: Salvo Grazia , Lashewicz Bonnie M. , Doyle-Baker Patricia K. , McCormack Gavin R.
Published: May 2018

Qualitative studies can provide important information about how and why the built environment impacts physical activity decision-making—information that is important for informing local urban policies. We undertook a systematized literature review to synthesize findings from qualitative studies exploring how the built environment influences physical activity in adults. Our review included 36 peer-reviewed qualitative studies published from 1998 onwards. Our findings complemented existing quantitative evidence and provided additional insight into how functional, aesthetic, destination, and safety built characteristics influence physical activity decision-making. Sociodemographic characteristics (age, sex, ethnicity, and socioeconomic status) also impacted the BE’s influence on physical activity. Our review findings reinforce the need for synergy between transportation planning, urban design, landscape architecture, road engineering, parks and recreation, bylaw enforcement, and public health to be involved in creating neighbourhood environments that support physical activity. Our findings support a need for local neighbourhood citizens and associations with representation from individuals and groups with different sociodemographic backgrounds to have input into neighbourhood environment planning process.
Water-Based Automobile Paints Potentially Reduce the Exposure of Refinish Painters to Toxic Metals
Authors: Hsu Der-Jen , Chung Shun-Hui , Dong Jie-Feng , Shih Hui-Chung , Chang Hong-Bin , Chien Yeh-Chung
Published: May 2018

Exposure to lead-containing dusts is a global public health concern. This work addresses an important issue of whether eco-friendly water-based paints reduce the exposure potential of auto-repainting workers to metals. With this aim, metal levels in automobile paints and worker metal exposure were measured using both solvent- and water-based paints. The levels of metals, and particularly Pb, Cr (total), Fe, and Cu, in solvent-based paints varied greatly among colors and brands. Lead concentrations ranged from below the detection limit (~0.25 μg/g) to 107,928 μg/g (dry film) across all samples. In water-based paints, the concentrations of Pb and Cr (total) were generally two to three orders of magnitude lower, but the concentrations of Al and Cu exceeded those in some solvent-based paints. The personal short-term exposure of workers who applied water-based paints of popular colors, such as black and white, were generally low, with Pb levels of less than <4 µg/m3 and Cr (total) levels of less than 1 µg/m3. Conversely, mean short-term exposure to Pb during the painting of a yellow cab using solvent-based paints were 2028 µg/m3, which was ~14 times the Taiwan short-term permissible exposure limit, while the mean level of exposure to Cr (total) was 290 µg/m3, which was well below the exposure limit. This study demonstrates that water-based paints reduce the exposure potential to lead, and highlights the importance of source control in limiting the toxic metals in paints.
Will Happiness Improve the Psychological Integration of Migrant Workers?
Authors: Li Tian-Cheng , Chu Chien-Chi , Meng Fan-Cun , Li Qin , Mo Di , Li Bin , Tsai Sang-Bing
Published: May 2018

Happiness is a major factor that influences people’s perceptions and behavior. Two-stage least squares regression was applied to investigate the effect of happiness on the psychological integration of migrant workers in China. The data for a total of 1625 individuals were obtained from the 2014 China Labor-force Dynamics Survey (CLDS). This study describes happiness from three main aspects: happiness, life satisfaction, and economic satisfaction. The psychological integration includes two dimensions of settlement willingness, and trust level; these have gone through dimension-reduced processing by using the weighted average method. The empirical evidence shows, first, that happiness has a significantly positive effect on the psychological integration of migrant workers and second, that the sense of life satisfaction in particular plays a more significant role. The acceleration of the social and political integration in migrant workers will enhance their psychological integration. Additionally, social, cultural and economic integration is found to influence migrant workers’ psychological integration by promoting happiness. Happiness between different generations of migrant workers was found to have a noticeably positive impact on their psychological integration; however, the happiness of the younger migrant workers was more perceivable than that of the other generations. Preferential policies should therefore be provided to improve the happiness of migrant workers.
Obstacles and Opportunities of Using a Mobile App for Marine Mammal Research
Authors: Hann Courtney H. , Stelle Lei Lani , Szabo Andrew , Torres Leigh G.
Published: May 2018

This study investigates the use of a mobile application, Whale mAPP, as a citizen science tool for collecting marine mammal sighting data. In just over three months, 1261 marine mammal sightings were observed and recorded by 39 citizen scientists in Southeast Alaska. The resulting data, along with a preliminary and post-Whale mAPP questionnaires, were used to evaluate the tool’s scientific, educational, and engagement feasibility. A comparison of Whale mAPP Steller sea lion distribution data to a scientific dataset were comparable (91% overlap) given a high enough sample size (n = 73) and dense spatial coverage. In addition, after using Whale mAPP for two weeks, citizen scientists improved their marine mammal identification skills and self-initiated further learning, representing preliminary steps in developing an engaging citizen science project. While the app experienced high initial enthusiasm, maintaining prolonged commitment represents one of the fundamental challenges for this project. Increasing participation with targeted recruitment and sustained communication will help combat the limitations of sample size and spatial coverage. Overall, this study emphasizes the importance of early evaluation of the educational and scientific outcomes of a citizen science project, so that limitations are recognized and reduced.
Oxygen-Induced Retinopathy from Recurrent Intermittent Hypoxia Is Not Dependent on Resolution with Room Air or Oxygen, in Neonatal Rats
Authors: Beharry Kay D. , Cai Charles L. , Skelton Jacqueline , Siddiqui Faisal , D’Agrosa Christina , Calo Johanna , Valencia Gloria B. , Aranda Jacob V.
Published: May 2018

Preterm infants often experience intermittent hypoxia (IH) with resolution in room air (RA) or hyperoxia (Hx) between events. Hypoxia is a major inducer of vascular endothelial growth factor, which plays a key role in normal and aberrant retinal angiogenesis. This study tested the hypothesis that neonatal IH which resolved with RA is less injurious to the immature retina than IH resolved by Hx between events. Newborn rats were exposed to: (1) Hx (50% O2) with brief hypoxia (12% O2); (2) RA with 12% O2; (3) Hx with RA; (4) Hx only; or (5) RA only, from P0 to P14. Pups were examined at P14 or placed in RA until P21. Retinal vascular and astrocyte integrity; retinal layer thickness; ocular and systemic biomarkers of angiogenesis; and somatic growth were determined at P14 and P21. All IH paradigms resulted in significant retinal vascular defects, disturbances in retinal astrocyte template, retinal thickening, and photoreceptor damage concurrent with elevations in angiogenesis biomarkers. These data suggest that the susceptibility of the immature retina to changes in oxygen render no differences in the outcomes between RA or O2 resolution. Interventions and initiatives to curtail O2 variations should remain a high priority to prevent severe retinopathy.
Screening of Natural Product Derivatives Identifies Two Structurally Related Flavonoids as Potent Quorum Sensing Inhibitors against Gram-Negative Bacteria
Authors: Manner Suvi , Fallarero Adyary
Published: May 2018

Owing to the failure of conventional antibiotics in biofilm control, alternative approaches are urgently needed. Inhibition of quorum sensing (QS) represents an attractive target since it is involved in several processes essential for biofilm formation. In this study, a compound library of natural product derivatives (n = 3040) was screened for anti-quorum sensing activity using Chromobacterium violaceum as reporter bacteria. Screening assays, based on QS-mediated violacein production and viability, were performed in parallel to identify non-bactericidal QS inhibitors (QSIs). Nine highly active QSIs were identified, while 328 compounds were classified as moderately actives and 2062 compounds as inactives. Re-testing of the highly actives at a lower concentration against C. violaceum, complemented by a literature search, led to the identification of two flavonoid derivatives as the most potent QSIs, and their impact on biofilm maturation in Escherichia coli and Pseudomonas aeruginosa was further investigated. Finally, effects of these leads on swimming and swarming motility of P. aeruginosa were quantified. The identified flavonoids affected all the studied QS-related functions at micromolar concentrations. These compounds can serve as starting points for further optimization and development of more potent QSIs as adjunctive agents used with antibiotics in the treatment of biofilms.
Definition of Motion and Biophysical Indicators for Home-Based Rehabilitation through Serious Games
Authors: Morando Matteo , Ponte Serena , Ferrara Elisa , Dellepiane Silvana
Published: May 2018

In this paper, we describe Remote Monitoring Validation Engineering System (ReMoVES), a newly-developed platform for motion rehabilitation through serious games and biophysical sensors. The main features of the system are highlighted as follows: motion tracking capabilities through Microsoft Kinect V2 and Leap Motion are disclosed and compared with other solutions; the emotional state of the patient is evaluated with heart rate measurements and electrodermal activity monitored by Microsoft Band 2 during the execution of the functional exercises planned by the therapist. The ReMoVES platform is conceived for home-based rehabilitation after the hospitalisation period, and the system will deploy machine learning techniques to provide an automated evaluation of the patient performance during the training. The algorithms should deliver effective reports to the therapist about the training performance while the patient exercises on their own. The game features that will be described in this manuscript represent the input for the training set, while the feedback provided by the therapist is the output. To face this supervised learning problem, we are describing the most significant features to be used as key indicators of the patient’s performance along with the evaluation of their accuracy in discriminating between good or bad patient actions.
Metal (Hg, Pt, Ru) Bisalkynyl Bridge between Tetrathiafulvalene Electrophores and Electronic Interplay
Authors: Auffray Morgan , Vacher Antoine , Roisnel Thierry , Lorcy Dominique
Published: May 2018

A series of metal (Hg, Pt, Ru) bis(alkynyl-tetrathiafulvalene) complexes have been investigated to study the electronic interplay between the metal and the tetrathiafulvalene (TTF), as well as between the two peripheral TTF electrophores along the organometallic bridge. Cyclic voltammetry experiments, together with spectro-electrochemical investigations, have shown the electronic effect of the metal center through the linker on redox properties of the TTF, as well as the influence of the length of the conjugated organic linker. These data show that the degree of coupling can be modulated from no coupling with mercury to appreciable electronic coupling between different electrophores with ruthenium.
A M2L2 Redox-Active Metalla-Macrocycle Based on Electron-Rich 9-(1,3-Dithiol-2-ylidene)Fluorene
Authors: Krykun Serhii , Allain Magali , Carré Vincent , Aubriet Frédéric , Voitenko Zoia , Goeb Sébastien , Sallé Marc
Published: May 2018

A redox-active M2L2 metalla-macrocycle is depicted, of which construction has been achieved through coordination driven self-assembly from an electron-rich 9-(1,3-dithiol-2-ylidene)fluorene bis-pyridyl ligand and a cis-blocked square planar palladium complex (Pd(dppf)OTf2, dppf = 1,1′-Bis(diphenylphosphino)ferrocene). The resulting metalla-macrocycle has been fully characterized in solution, as well as in the solid state (X-ray crystal structure). Its electronic properties show that both constitutive ligands can be oxidized independently through a one-electron process.
Constructal Design of a Rectangular Fin in a Mixed Convective Confined Environment
Authors: Cong Ran , Ozaki Yu , Machado Bruno S. , Das Prodip K.
Published: May 2018

Extended surfaces or fins offer an efficient solution in many engineering situations that demand a higher heat transfer, including cooling gas-turbine components and electronic chips via internal convective flows. However, fins require a higher active surface area for higher heat transfer, which may not be always feasible in a confined environment. A feasible solution to enhance heat transfer from fins can be the use of nanofluids, which are the combination of a fluid base and nanoparticles. The main purpose of this study is, therefore, to optimize a rectangular fin intruded into the mixed convective confined space filled with a nanofluid and by means of constructal design. Here, a two-dimensional macroscopic numerical model has been developed for Al2O3–water nanofluid to investigate the heat transfer and fluid flow inside a square confined-space with an intruded rectangular fin and to optimize the fin geometry for maximizing the heat transfer using the constructal design method. The flow fields, temperature fields, heat transfer rates, and the transition from forced to mixed convection are examined for different values of Rayleigh and Reynolds numbers for various fin geometries in order to maximize the heat transfer from the fin to the surrounding nanofluid flow. The outcome of this study provides important insights into the constructal design method for the confined environment, which would be beneficial in developing novel fin geometries with enhanced and controlled heat-transfer for engineering problems, including cooling gas-turbine components and electronic chips.
Cholesterol Efflux: Does It Contribute to Aortic Stiffening?
Authors: Liao Shutan , McLachlan Craig S.
Published: May 2018

Aortic stiffness during cardiac contraction is defined by the rigidity of the aorta and the elastic resistance to deformation. Recent studies suggest that aortic stiffness may be associated with changes in cholesterol efflux in endothelial cells. This alteration in cholesterol efflux may directly affect endothelial function, extracellular matrix composition, and vascular smooth muscle cell function and behavior. These pathological changes favor an aortic stiffness phenotype. Among all of the proteins participating in the cholesterol efflux process, ATP binding cassette transporter A1 (ABCA1) appears to be the main contributor to arterial stiffness changes in terms of structural and cellular function. ABCA1 is also associated with vascular inflammation mediators implicated in aortic stiffness. The goal of this mini review is to provide a conceptual hypothesis of the recent advancements in the understanding of ABCA1 in cholesterol efflux and its role and association in the development of aortic stiffness, with a particular emphasis on the potential mechanisms and pathways involved.
Some Isolated Cardiac Malformations Can Be Related to Laterality Defects
Authors: Versacci Paolo , Pugnaloni Flaminia , Digilio Maria Cristina , Putotto Carolina , Unolt Marta , Calcagni Giulio , Baban Anwar , Marino Bruno
Published: May 2018

Human beings are characterized by a left–right asymmetric arrangement of their internal organs, and the heart is the first organ to break symmetry in the developing embryo. Aberrations in normal left–right axis determination during embryogenesis lead to a wide spectrum of abnormal internal laterality phenotypes, including situs inversus and heterotaxy. In more than 90% of instances, the latter condition is accompanied by complex and severe cardiovascular malformations. Atrioventricular canal defect and transposition of the great arteries—which are particularly frequent in the setting of heterotaxy—are commonly found in situs solitus with or without genetic syndromes. Here, we review current data on morphogenesis of the heart in human beings and animal models, familial recurrence, and upstream genetic pathways of left–right determination in order to highlight how some isolated congenital heart diseases, very common in heterotaxy, even in the setting of situs solitus, may actually be considered in the pathogenetic field of laterality defects.