bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of the thalamic reticular neurons in alpha- and gamma-oscillations in neocortex: a mechanism for selective perception and stimulus binding
Authors: Skinner James , Molnar Mark , Kowalik Zbigniew
Published: December 2023

The long-term objective is to understand how large masses of neurons in the brain process information during various learning and memory paradigms. Both time- and space-dependent processes have been identified in animals through computer-based analytic quantifications of event-related extracellular potentials. New nonlinear analyses have been introduced that presume that the fine-grain variation in the signal is determined and patterned in phase-space. Some neurons in the primary visual cortex manifest gamma-band oscillations. These cells show both a nonspecific phase-alignment (response synchrony) and a specific tuning (orientation tuning) when stimuli are presented to their receptive fields. This dual regulation of the sensory cells is proposed to underlie stimulus binding, a theoretical mechanism for "object" perception. Nonlinear analytic results from gamma-activities in a simple model neuropil (olfactory bulb) suggest that neuroplasticity may arise through self-organization, a process in which a nonlinear change in the dynamics of the oscillatory field potentials is the hallmark. This self-organization may follow simple dynamical laws in which global cooperativity among the neurons is transiently brought about that, over trials, results in enduring changes in the nonlinear dynamics of some neurons. In conclusion, the sculpturing of the synaptic throughput in the sensory cortex (stimulus binding) may be associated with the irregular phases of the gamma-activities and may result from both specific and nonspecific systems operating together in a nonlinear self-organizing manner.
Involvement of nitric oxide in regulation of the medullary respiratory rhythm in neonatal rats
Authors: Volgin Denis , Volgina Alia , Seredenko Mykhailo
Published: December 2023

The NADPH-diaphorase (as a neuronal NO-synthase) reactivity in the medullary structures of the respiratory rhythm (RR) generator and the role of NO in the regulation of respiratory activity in the phrenic nerve of artificially superfused semi-isolated medulla-spinal cord preparations were investigated in newborn rats. NADPH-diaphorase positive neurons were found in all nuclei of both dorsal and ventral respiratory groups of neurons. The maximal density of stained cells was present within the rostral part of the ventrolateral medulla (VLM), in the region of the lateral paragigantocellular reticular nucleus. It was found that endogenous NO mediates the mechanism of tonic inhibitory control of the RR frequency located in the rostral VLM under normal and hypoxic conditions, and appears to be involved in generation of the basic RR by the more caudal structures of VLM. It was shown that NO biosynthesis mediates the effect of NMDA receptors activation on the RR.
Oestrogen effects on kainate-induced toxicity in primary cultures of rat cortical neurons
Authors: Kajta Małgorzata , Lasoń Władysław
Published: December 2023

Oestrogens protect neurons against excitatory amino acid-induced toxicity; however data on their interaction with particular subtype of glutamate receptors are sparse. Therefore in the present study we investigated oestrogen effects on kainate neurotoxicity in primary cortical neurons. The data showed that both oestradiol-17beta and oestrone (100 nM and 200 nM) reduced kainate toxicity by ca. 40%. Since tamoxifen only partly inhibited the above effects, we suggest that both genomic and non-genomic mechanisms are involved in the anti-kainate action of oestrogens.
Effect of unilateral injection of MK-801 into the area of A10 cells on feeding evoked by stimulation of homologous area in the contralateral hemisphere
Authors: Maliszewska-Ścisło Maria , Trojniar Weronika
Published: December 2023

It was found previously that unilateral electrolytic and 6-OHDA lesions of the ventral tegmental area (VTA) and unilateral intra- VTA injection of bicuculline resulted in facilitation of behavioral responses evoked by electrical stimulation of the symmetrical VTA area in the contralateral hemisphere. We postulated that "the contralateral facilitation effect", which may reflect the yet unexplored mechanism of immediate compensation after acute unilateral brain injury, is attributable to the A10 DA neurons and their regulatory inputs. The present study was aimed at examining the possible involvement of NMDA-mediated glutamatergic transmission in VTA in the "contralateral facilitation effect". The behavioral model of the VTA stimulation-induced feeding in rats was used. Latency to eat was measured as a function of stimulation frequency before and after unilateral intra-VTA injection of non-competitive NMDA receptors antagonist, MK-801, (doses 0.0, 1.25 and 2.5 micrograms), MK-801 caused a dose-dependent augmentation of feeding evoked by stimulation of the contralateral VTA, which manifested as a decrease in the reaction frequency threshold and a leftward shift of the latency/frequency curve. Dose 2.5 micrograms replicated the facilitatory effect of electrolytic and 6-OHDA lesions. The results are interpreted in terms of MK-801-evoked depression of excitatory glutamatergic tone over A10 DA cells and compensatory increase in DA release in the contralateral hemisphere.
Complexity analysis of spontaneous EEG
Authors: Bhattacharya Joydeep
Published: December 2023

The aim of the present paper is the assessment of the overall complexity of spontaneous and non-paroxysmal EEG signals obtained from three groups of human subjects, e.g., healthy, seizure and mania. Linear complexity measure suitable for multi-variate signals, along with nonlinear measures such as approximate entropy (ApEn) and Taken's estimator are considered. The degree of linear complexity is significantly reduced for the pathological groups compared with healthy group. The nonlinear measures of complexity are significantly decreased in the seizure group for most of the electrodes, whereas a distinct discrimination between the maniac and healthy groups based on these nonlinear measures is not evident.
Brain injury: prolonged induction of transcription factors
Authors: Pennypacker Keith , Kassed Cheryl , Eidizadeh Shabnam , O'Callaghan James
Published: December 2023

A specific temporal order of events at the cellular and molecular level occurs in response to injury to the brain. Injury-compromised neurons degenerate while surviving neurons undergo neuritogenesis and synaptogenesis to establish neuronal connectivity destroyed in the injury. Several genes, such as those coding cytoskeletal proteins and growth factors, have been shown to be regulated by AP-1 and NF-kappaB transcription factors, two of the most studied DNA binding regulatory proteins. Our laboratory has discovered that Fos-related antigen-2 from AP-1 transcription factor family and NF-kappaB p65 and p50 subunits are induced long-term (days to months) in the brain after neurotoxic, excitotoxic or ischemic insult. Fos-related antigen-2 is induced in neurons in several models of injury and its elevated expression lasts days to months, corresponding to the severity. The time-course of FRA-2 induction is abbreviated with less severe insult (terminal damage) relative to the cell death, but the induction occurs during the period of regeneration and repair in both models. NF-kappaB p65 is basally expressed in hippocampal and cortical neurons, but is elevated in reactive astrocytes in hippocampus and entorhinal cortex starting at two days and lasting at least two weeks after kainate treatment. Neurons of the hippocampus surviving ischemic or neurotoxic injury increase expression of NF-kappaB p50 for at least a week after injury, suggesting a function for p50 in neuronal survival and/or repair. The extended expression of these transcription factors implies a role in the activation of genes related to repair and regeneration, such as growth factors and synaptic proteins, after injury to the CNS.
Signaling pathways mediating anti-apoptotic action of neurotrophins
Authors: Hetman Michal , Xia Zhengui
Published: December 2023

Neurotrophins promote survival and suppress apoptosis in many populations of neurons. Currently, phosphatidylinositol-3 kinase (PI-3K) is recognized as the main mediator of this protective effect. However, most of the data collected so far on the anti -apoptotic signaling of neurotrophins were obtained using trophic withdrawal paradigms. Recent data from our and other groups indicate that extracellular-signal-regulated kinase 1/2 (Erk1/2) 1may playa critical role in suppressing neuronal apoptosis triggered by cellular damage. Thus, it appears that either Erk1/2 or PI-3K, depending on the nature of the death-inducing stimulus, can mediate anti-apoptotic signaling of neurotrophins. In this review, we discuss the contribution of Erk1/2 and PI-3K to neuroprotection by neurotrophins. We also present data suggesting possible mechanisms by which these pathways might suppress neuronal death.
Regulation of cell specific expression of calcyclin (S100A6) in nerve cells and other tissues
Authors: Leśniak Wiesława , Swart Guido , Bloemers Henri , Ku¼nicki Jacek
Published: December 2023

Many of the small, acidic, calcium binding S 100 proteins present in the brain specifically map different anatomical regions and cell types and their overexpression is implicated in pathological changes. Similarly to other members of the S100 protein family, calcyclin (S100A6) is expressed in a cell specific manner and is found in subpopulations of neurons and astrocytes in the brain and in epithelial cells and fibroblasts. In this article we review data concerning the cell specific expression of S100 protein genes and present experimental results on the regulation of the calcyclin gene. We have performed promoter deletion studies to locate regions within the calcyclin gene promoter responsible for transcriptional regulation. The results demonstrate that the 3 kb long calcyclin gene promoter lacks a cell specific cis-acting element and drives the expression of the reporter gene also in cells that do not express endogenous calcyclin. The expression is modulated by positive and negative elements acting uniformly in the four different cell lines studied. The first intron of the calcyclin gene was found to have an inhibitory influence on expression regardless of cell type. It was also shown that calcyclin expression can be induced in calcyclin-negative cells by treatment with 5-azacytidine suggesting the involvement of gene methylation in its cell specific expression. The results are discussed in light of the data available on the regulation of other S100 genes.
Göreceliğin Ötesindeki Gerçek: Karl Mannheim’ın ‘Düşünce Yapıları’
Authors: Akbaş Arif
Published: December 2023

Özet
Bu makalede ünlü Macar-Alman filozofu ve entelektüeli Karl Mannheim’ın 1922-24’te yayımlanan ilk eseri olan “Structures of Thinking” Düşünce Yapıları kitabı Weberci yorumlayıcı yaklaşım [Verstehende] çerçevesinde incelenip, tartışılacaktır. Mannheim, kıta Avrupası ve dünya düşünce tarihi içinde özellikle; “İdeoloji ve Ütopya: Bilgi Sosyolojisine Bir Giriş”, “Yeniden Yapılanma Çağında İnsan ve Toplum”, “Zamanımızın Teşhisi: Bir Sosyoloğun Savaş Zamanı Denemeleri”, “Özgürlük, Güç ve Demokratik Planlama”, “Bilgi Sosyolojisi Üzerine Denemeler”, “Sosyoloji ve Sosyal Psikoloji Üzerine Yazılar”, “Kültür Sosyolojisi Üzerine Yazılar”, “Sistematik Sosyoloji”, “Eğitim Sosyolojisine Giriş”, “Muhafazakarlık: Bilgi Sosyolojisine Bir Katkı” yapıtlarıyla ön plana çıkmaktadır. O klasik sosyolojinin önemli isimlerinden biri olmasının yanı sıra bilgi sosyolojisinin kurucularından biridir. Mannheim, en çok kısmi ve toplam ideolojiler arasında ayrım yaptığı İdeoloji ve Ütopya (1929/1936) adlı kitabıyla tanınır. Mannheim, Arnold Hauser ve Erwin Szabó ile birlikte, Georg Lukács’ın da ders verdiği Budapeşte Özgür Beşerî Bilimler Okulu’nun kurucusudur. Mannheim’ın bilgi sosyolojisine ilişkin teorisi, Immanuel Kant’ın bazı epistemolojik keşiflerine dayanmaktadır. Bilgi sosyolojisi, kültür sosyolojisi olarak bilinen daha geniş bir alanın bir bölümü olarak bilinir. Kültür sosyolojisi fikri, kültür ve toplum arasındaki ilişki olarak tanımlanmaktadır. Toplumdan topluma değişen göreceliğin ötesindeki yegâne gerçek kültürdür. Kültür sosyolojisinin iki ana dalı vardır: Ilımlı bir dal ve radikal bir dal. Ilımlı dal, sosyal koşulların bilgi içeriğini etkilemediğine inanan Max Scheler tarafından temsil edilmektedir. Radikal dal ise tam tersine toplumun kültürün tüm yönleriyle belirlendiğini vurgular. Mannheim, bilginin toplumsal gerçekliğe bağımlılığını kurduğuna inanıyordu. Bu bağ kuruş ise düşünce/ sınıf yapılarındaki farlılıklardan kaynaklanmaktaydı. Her ne kadar Mannheim Marksist olmaktan uzak olsa da bilgi sosyolojisi büyük ölçüde Marx’ın sınıflara ilişkin teorilerine dayanıyordu.
Tecnologia promissora no combate à leucemia Linfoblástica aguda: explorando a eficácia da imunoterapia CAR-T
Authors: Prass Débora Tatiane Zamboni , Porto Emmylle Soares , Santos Iranilde Silva dos , Delgado Neto Leoncio Rodrigues , Pereira Savyo Geovanne Silva , Perondi Brenda Lúcia Burtuli
Published: December 2023

A leucemia linfóide aguda (LLA) é um tipo de câncer que afeta as células sanguíneas e da medula óssea. É mais comum em crianças e adultos jovens, representando a maior parte dos casos de câncer infantil. A LLA pode ser tratada com quimioterapia intensiva, mas esse tratamento pode ter efeitos adversos significativos, especialmente em pacientes jovens. Nos últimos anos, a imunoterapia com células CAR-T tem se destacado como uma nova abordagem promissora para o tratamento da LLA. As células CAR-T são células do sistema imunológico modificadas em laboratório para atacar especificamente as células cancerígenas. Estudos têm mostrado taxas de remissão completa de até 90% em pacientes tratados com células CAR-T. No entanto, esse tratamento também pode ter efeitos colaterais importantes, como a síndrome de liberação de citocinas e a neurotoxicidade. Apesar disso, a terapia com células CAR-T tem mostradoresultados promissores e pode ser uma opção eficaz para pacientes com LLA refratária ou recidivante. Objetivo: Discorrer sobre a LLA enfatizando a eficácia da imunoterapia com células CAR-T como tratamento inovador. Metodologia: Foi realizada uma revisão integrativa de literatura por meio de publicações indexada as bases de dados Scielo, Google Acadêmico, PubMed e Biblioteca Virtual em Saúde (BVS), utilizando os descritores: CAR-T, Leucemia Linfoide Aguda, Recidiva em crianças e Imunoterapia em LLA. A utilização da terapia com células CAR-T para o tratamento dessa enfermidade tem sido considerada uma abordagem promissora, com resultados animadores na viabilidade e na segurança do seu uso, mostrando-se uma ferramenta poderosa e de alta seletividade, o que permite o foco específico nas células malignas.
Desafios e dificuldades enfrentados pelos estudantes no processo de aprendizagem matemática
Authors: Viana Esdriane Cabral , Amorim Ricardo José Rocha , Amorim Dinani Gomes
Published: December 2023

O estudo da matemática é frequentemente acompanhado de desafios e dificuldades, que podem prejudicar o processo de aprendizagem dos estudantes. Neste sentido, realizou-se um mapeamento sistemático para descrever os obstáculos enfrentados pelos estudantes no processo de aprendizagem matemática. Identificou-se que a aprendizagem é influenciada por diversos fatores, e que as dificuldades de aprendizagem podem afetar o progresso dos alunos. No entanto, existem estratégias eficazes para lidar com essas dificuldades e aprimorar o processo de aprendizagem matemática dos estudantes.
Mortalidade hospitalar no sistema único de saúde por DPOC pré e durante a pandemia da COVID-19 no estado do Paraná
Authors: Santoro Camila Miqueleto , Dantas Aélem Cristina Apoliceno , De Oliveira Daniel Vicentini , Ferreira Elenice Gomes
Published: December 2023

Objetivo: Analisar a mortalidade hospitalar no SUS por DPOC, levando como variável o local de internação dentre as regiões de saúde do Estado do Paraná e a faixa etária dos indivíduos, de 60 a 80 anos e mais, comparando assim os anos de 2020-2021 com os dois anos anteriores a pandemia do Covid-19, os anos de 2018-2019. Métodos: Estudo retrospectivo de análise estatística, onde os levantamentos dos dados foram extraídos do TABNET SUS, utilizando as variáveis citadas anteriormente. Resultados: Com base na faixa etária, no período 2018/2019 a média de permanência hospitalar e o número de óbitos por DPOC foram maiores do que nos anos de 2020/2021, sendo que quanto maior a faixa etária, maior a quantidade de óbitos. Assim, com base na região de saúde, a média de dias de permanência hospitalar e o número de óbitos foi maior nos anos de 2018/2019 quando comparado aos dois anos posteriores. Porém a taxa de mortalidade foi consideravelmente maior nos anos de pandemia, 2020/2021. Conclusão: Devido ao panorama vivido atualmente, a pandemia do COVID-19, um número menor de pessoas participou da estatística dos anos de 2020/2021, consequente da menor procura por atendimento médico, provavelmente devido ao medo de contaminação por parte dos indivíduos portadores da doença pulmonar obstrutiva crônica, por se sentirem mais vulneráveis.
A ESCUTA ATIVA DE IDOSOS COMO UMA FERRAMENTA DE RESILIÊNCIA
Authors: Brito Pedro Vinicius de Souza , Da Motta Ivonise Fernandes
Published: December 2023

Embora o envelhecimento seja um processo natural, a sociedade muitas vezes encara a velhice como uma fase em que a pessoa perde sua utilidade. O problema se intensifica quando o próprio idoso internaliza essa visão, podendo até antecipar sua morte. Conforme dados da Organização Mundial de Saúde, observa-se um aumento nos casos de suicídio entre idosos, fenômeno que pode ter sido exacerbado pela pandemia, uma vez que esse grupo foi especialmente afetado. Nesse contexto, a logoterapia surge como uma alternativa crucial para auxiliar os idosos em crise, oferecendo-lhes a oportunidade de encontrar um significado renovado em suas vidas. Apresentaremos dois casos no qual essa abordagem foi seguida para ajuda-los a encontrar em seus discursos um sentido para suas vidas. Ao proporcionar apoio psicológico, a logoterapia pode ser instrumental na prevenção do suicídio, ajudando os idosos a reconhecerem e cultivarem um propósito que os motive a superar as dificuldades. Isso é particularmente importante diante dos desafios agravados pela pandemia, reforçando a necessidade de abordagens terapêuticas centradas na busca de sentido para enfrentar as adversidades enfrentadas por essa parcela da população.
About methodological basis of Alban Berg’s creative process
Authors:   Nizhny Novgorod Glinka State Conservatory, Veksler Yulia S.
Published: December 2023

The article discusses theoretical and methodological origins of Alban Berg’s creative process. A study of how methods of analysis and theoretical concepts of the corresponding period affect the genesis of the musical work and meet the peculiarities of a composer’s musical thinking, reveals the points of contact between the theory of music and composition. Our hypothesis is that energeticism as the most influential theoretical concept determined not only how music was listened to, analyzed and interpreted, but also how it was composed. Our aim is to share the results of the study by R. Schäfke (1934) with the scientific community. One of its chapters focuses on energeticism as a key area of modern musical aesthetics represented by Heinrich Schenker, August Halm, Ernst Kurth, Hans Mersmann, Fritz Jöde, Hermann Roth, Wilhelm Werker, and Walter Krug. The study is based on an extensive body of sources including letters, diaries, notes as well as articles written in different years. It focuses on the reception of energeticism, primarily the concepts of Schenker, Kurth, and Werker, in the Schoenberg circle. It is obvious that Alban Berg adopted the ideas of energetism which is evidenced, first and foremost, by his music. Unaware of contemporary theoretical concepts, Berg intuitively approached them in his creative process, whose early stages are marked by “energy-structural dualism” (according to T. Tsaregradskaya). The closest analogy in the algorithm of Berg's composition is Schenker's idea of the primary structure as an embryo of future composition (except for the cases of classical harmony).
Evaluator Education for the Twenty-First Century: The Centrality of Developing Evaluators’ Interpersonal Competencies
Authors: King Jean
Published: December 2023

This paper first traces the development of competencies for professional evaluators and identifies interpersonal competencies as a key component of evaluator education in the future. It then outlines two roles for evaluators that may affect the application of interpersonal competencies, discusses four ideas for their development, and briefly addresses the possibility of evaluation capacity building. It concludes with a brief discussion of where and how evaluator training or education might effectively teach these competencies and know that people had learned them.
RESEARCH ON AERODYNAMIC NOISE CHARACTERISTICS OF HELICOPTER ROTORS CONSIDERING THE INFLUENCE OF BLADE SHAPES
Authors:   Le Quy Don Technical University, Hanoi, Vietnam, Le Quang Quyen
Published: December 2023

In this study, we investigated the influence of blade shapes on the aerodynamic noise characteristics of helicopter main rotors by the vortex method. The obtained results are the variation of the time-dependent lift coefficient of rotors and the aerodynamic noise characteristics of the helicopter rotor with different blade shapes. On that basis, the influence of the blade shape on the aerodynamic noise characteristics of helicopter rotors was evaluated. An advanced blade shape was designed to reduce the aerodynamic noise of rotors while maintaining the lift of the rotor. Computational results show that the rotor with the advanced blade generates the lower noise, and the noise of the advanced blade reduces by up to 6.15 dB (reduced by 6.90%) compared with the common rectangular blade in hover and up to 5.4 dB (reduced by 5.15%) in forward flight.
PENGENALAN DAN PENANAMAN TANAMAN HIAS MENGGUNAKAN BERBAGAI MEDIA TANAM BAGI SISWA SD PEDAGOGIA YOGYAKARTA
Authors: Yuniasih Betti , Ardiani Fani , Noviana Githa
Published: December 2023

Kegiatan P5 pada kurikulum merdeka diharapkan dapat menanamkan karakter pada pribadi peserta didik berdasarkan nilai-nilai Pancasila. Gaya hidup berkelanjutan merupakan salah satu tema dalam kegiatan P5. Pengenalan pertanian pada anak merupakan salah satu kegiatan yang termasuk dalam gaya hidup berkelanjutan perlu diajarkan sedini mungkin. Tujuan dari kegiatan ini adalah memberikan pengalaman bagi anak untuk mengenal berbagai media tanam, cara menanam tanaman di berbagai media tanam, dan cara merawatnya. Kegiatan pengabdian ini dilaksanakan di SD Pedagogia Yogyakarta. Kegiatan pengabdian dilakukan dengan memberikan ceramah kepada siswa kelas 1 tentang macam-macam media tanam serta penyiapan media sebelum menanam. Selanjutnya siswa diajak menaman tanaman hias menggunakan berbagai media tanam. Setiap anak memiliki tanggung jawab untuk merawat tanamann masing-masing. Melalui kegiatan ini siswa dapat mengenal berbagai macam media tanam, mengetahui perlakuan persiapan penanaman dengan berbagai media tanam, serta dapat menanam dan merawat tanaman hias dengan berbagai media tanam.
Tahkimde Gerilla Taktikleri ve Gerilla Taktiklerinin Önlenmesi
Authors: GENÇ Talha
Published: December 2023

Tahkim yargılaması uluslararası alanda sıklıkla başvurulan etkin bir yargılama biçimidir. Tahkim yargılamasının kendine özgü yapısı ve giderek yaygınlaşması, tarafların, taraf vekillerin ve menfaat temin etmek isteyen hakemlerin tahkim yargılamasını engelleyici ve erteleyici davranışlara başvurmasına sebebiyet vermektedir. Taraflar, taraf vekilleri ve hakemler tarafından tahkim yargılamasının olağan akışını bozan bu tür davranışlar gerilla taktikleri olarak ifade edilmektedir.

Bu makalede, öncelikle hangi tür davranışların gerilla taktiği niteliğinde olduğu belli bir sınıflandırma yapılarak tespit edilmiş daha sonra da tahkim yargılamasının akışını bozan gerilla taktiği niteliğindeki davranışların engellenebilmesi maksadıyla Uluslararası Barolar Birliği (International Bar Association – IBA) tarafından oluşturulan davranış kuralları, doktrindeki görüşler de dikkate alınarak incelenmiş ve gerilla taktiklerini önlemeye yönelik birtakım çözüm önerilerinde bulunulmuştur.
İpotekte Boş Dereceye İlerleme Sözleşmesinin Geçerliliği Bakımından Uyulması Gereken Şekil Şartı
Authors: AYDIN ATEŞ Gülşah Sinem
Published: December 2023

Boş dereceye ilerleme hakkı, ipotek sözleşmesine konan bir kayıt ile tanınabileceği gibi, ipotek kurulduktan sonra taşınmaz maliki ve alt derecedeki rehinli alacaklı arasında yapılacak bir sözleşme ile de tanınabilir. Türk Medenî Kanunu m. 871/III uyarınca boş dereceye ilerleme sözleşmesinin geçerliliği resmî şekil şartına uygun olarak yapılmasına bağlıdır. Resmî senedin tapu sicil müdürlüklerince yapılmasının uygun olacağı düşünülebilirse de, Tapu Kanunu m. 26’da tapu sicil müdürü veya tapu sicil görevlileri tarafından düzenlenmesi gereken resmî senetler arasında boş dereceye ilerleme sözleşmesi sayılmamaktadır. Noterlik Kanunu m. 60/bent 2 uyarınca da ülkemizde bir kanunda resmî senet düzenleme yetkisi başka bir resmî makama verilmedikçe, yetki noterlerdedir. Öğretide Türk Borçlar Kanunu m. 13 gereğince ipotek sözleşmesinin kurulmasından sonra yapılan boş dereceye ilerleme sözleşmesinin, ipotek sözleşmesinin şekline tâbi olduğu ve resmî senedin Tapu Kanunu m. 26/I uyarınca tapu müdürlüğünde düzenlenmesi gerektiği belirtilmektedir. Buna karşılık çalışmada söz konusu ihtimalde boş dereceye ilerleme sözleşmelerine resmiyet vermesi gereken makamın noter olduğu, bununla beraber tapu memurlarının da yetkili sayılabileceği düşüncesi savunulmuştur.
DEVELOPMENT OF NOVEL COMPARISON BASED STEGANOGRAPHY ALGORITHMS ON MULTIMEDIA TO HIDE PRIVATE DATA
Authors: MİLLİ Musa , KHASSENOV Daniyar
Published: December 2023

Throughout history, humanity has had secrets to safeguard, information that needed to be conveyed to allies in a way that enemies couldn't decipher. To achieve this goal of safeguarding important and valuable information, cryptography and steganography have been frequently used methods both in the past and in today's world. This article introduces a steganographic algorithm designed for hiding data in the color images, along with two different algorithm designs derived from this method. The bits of the hidden message are embedded sequentially into each pixel using the bit comparison. The comparison method works by matching the bits of the image and the message. The least significant bits (LSB) of the carrier (cover) image bytes change depending on the number of matching bits between the carrier image and the hidden message. The proposed method has the potential to hide 1 byte of data within 5 bytes under optimal conditions. The designed algorithms have been tested on a series of color images, and satisfactory results have been achieved in terms of embedding a sufficient amount of data into the images without compromising image quality. The results have been compared with the results of the LSB technique and similar methods based on various performance criteria.
INTELIGÊNCIA ARTIFICIAL FRENTE A RESOLUÇÃO DE EXERCÍCIOS DE QUÍMICA: UM ESTUDO EXPLORATÓRIO COM O CHATGPT
Authors: Eugenio Ingrid Domene , Silva Leonardo Augusto Natércio da , Santos Caio Murilo dos , Gibin Gustavo Bizarria
Published: December 2023

New forms of Artificial Intelligence are gaining more space at schools and among students. ChatGPT stands out for its easy use and, in Chemistry Teaching, this tool has stood out for the numerous possibilities, including problem solving. However, there is still not 100% certainty of the effectiveness of such instrument. This work aims to investigate the potential and capacity of ChatGPT to solve exercises involving stoichiometric calculations and balancing chemical equations. These problems were extracted from a textbook for 2nd year of high school widely used by Basic Education teachers and approved by the National Textbook Program. Due to the research exploratory nature, four questions were selected, two simpler and two more laborious and complex. Furthermore, in case the ChatGPT presented the result incorrectly, some tests were performed to analyze whether a change in the statement would also generate a change in the results. These, by the way, reveal that the chat excels in the language used, as it is simple and easy to understand. On the other hand, it disappointing when solving stoichiometry problems, as it confuses concepts and does not consider all atoms when balancing an equation. In other words, unless it is already balanced correctly, the use of ChatGPT it is not indicated for solving exercises of this type and despite being a promising tool with some qualities, it is not recommended for those who do not have complete knowledge and/or a necessary discernment to detect the mistakes it made and correct them.
II WIDE: Desafios em Interação Humano-Dados para a América Latina
Authors: Brito Luciana , França Juliana , Dias Angélica , Vivacqua Adriana , Morais Luiz , Queiroz Caroline , Freire André , Saraiva Juliana
Published: December 2023

Atualmente muitos dados são produzidos e utilizados de formas que afetam a vida das pessoas, que por vezes têm dificuldade para entender os dados, processos e resultados derivados. Interação humano-dados (IHD) propõe incluir os Humanos no centro do fluxo de dados, promovendo mecanismos aos cidadãos para interagir com esses sistemas e dados. A IHD investiga como pessoas interagem com dados, analogamente à definição de interação humano-computador (IHC), que investiga a relação entre humanos e computadores. Em um contexto de crescente volume de dados, a IHD torna-se cada vez mais relevante, abordando questões sobre acesso da população leiga a dados e visualizações, a capacidade de manipular e explorar esses dados (em meios virtuais ou físicos) e entender o que está sendo dito, bem como limitações e viéses dos datasets que afetarão resultados e as representações apresentadas. Este workshop tem por objetivo fomentar uma discussão do tema de interação humano-dados e sistemas correlatos (ex: visualização, fisicalizações, literacia de dados), apoiando a formação de uma comunidade em torno do assunto, e traçando caminhos para pesquisas futuras sobre o tema. Haverá uma chamada de trabalhos e recorreremos a estes e às contribuições de convidados como ponto de partida para discussões.
Prototypes of Very High Fidelity, Accessibility, and Reusability with Laum
Authors: Oliveira Francisco , Batista Rootedy , Araujo Thiago , Morais Breno , Oliveira Deivith
Published: December 2023

This paper presents LAUM, a library of micro frontends (MFE) with very high usability and accessibility. LAUM's components are made available in design time via the Figma plugin. LAUM narrows the gap between designers and developers, making highly reusable components discoverable at design time. Accessibility is a given since it is built into all components. Early testing is assured by the plugin's HTML generator (accessible html + MFE calls).
TEABot no Universo das Expressões
Authors: Lopes Júlio César da Costa , Santos José Antônio Pedro dos , Souza Ellen
Published: December 2023

Todas as pessoas vivenciam emoções. No entanto, há indivíduos que enfrentam dificuldades ao expressar, reconhecer, processar e regular suas emoções, um distúrbio denominado Alexithymia. O TEABot é um aplicativo gamificado, utilizado para o treinamento e reconhecimento de expressões faciais emocionais. O app faz uso de inteligência artificial para identificar a expressão facial realizada pelo paciente e personalizar o seu aprendizado, oferecendo uma forma mais inteligente e lúdica no tratamento da Alexithymia.
Um Resumo do Artigo - Projeto e Avaliação de uma Plataforma de Autoria para Jogos Digitais Terapêuticos
Authors: Rodrigues Kamila Rios da Hora , Verhalen Aline Elias Cardoso , Silva Jonattan Willian da , Silva Tiago Marino , Zavarizz Rodrigo Geurgas , Neris Vânia Paula de Almeida , Souza Paula Maia de
Published: December 2023

Os jogos digitais terapêuticos visam apoiar os tratamentos de reabilitação e ajudar os pacientes a compreenderem, se motivarem e persistirem nas práticas terapêuticas. A construção desses jogos, porém, ainda é realizada com o apoio de profissionais da área de Computação. Este trabalho apresenta a plataforma RUFUS para autoria de jogos digitais, na qual profissionais de diferentes áreas podem criar suas próprias instâncias de jogo a partir de templates com mecânicas pré-definidas. A plataforma foi desenvolvida seguindo preceitos da área de EUP (End-User Programming) e dispõe de duas interfaces distintas: uma interface Web, para autoria de jogos por parte do profissional (atualmente composta por cinco mecânicas de jogos diferentes) e um aplicativo móvel, em que o jogo é entregue ao público-alvo dos profissionais. A plataforma também oferece a visualização de relatórios de interação. Técnicas de design participativo foram usadas durante o design e a avaliação das mecânicas disponíveis, e envolveu diferentes partes interessadas no projeto. Diversas avaliações empíricas e analíticas foram realizadas nas interfaces da RUFUS, todas apresentando resultados positivos. Novos estudos com usuários-alvo, no entanto, ainda são necessários para aperfeiçoar a plataforma.
Laboratório de Inovação na Agência Nacional de Águas e Saneamento Básico - ANA INOVA
Authors: Barbosa Luísa Tristão , Souza Jaqueline Isabel de , Griboski Pablo , Capeleti Bruna S. , Freire André P. , Coelho Gilberto
Published: December 2023

Este artigo apresenta a experiência com o uso de técnicas de Design Centrado no Humano no contexto do ANA Inova, laboratório de inovação da Agência Nacional de Águas e Saneamento Básico (ANA). O ANA Inova é um espaço institucional que busca promover a inovação nos desafios de gestão e regulação, com atividades ao longo de dois anos, em parceria com a Universidade Federal de Lavras.
Relâmpagos de Saudade: Aplicativo móvel para homenagens póstumas
Authors: Campos Lucas A. S. , Maciel Cristiano , Trevisan Daniele
Published: December 2023

Esta pesquisa apresenta o projeto de um aplicativo móvel, intitulado Relâmpagos de Saudade, com a finalidade de expressar rápidas homenagens póstumas. Esta pesquisa é do tipo aplicada, com abordagem qualitativa, utilizando de métodos e técnicas apropriados ao desenvolvimento do sistema.
Caixa de Ideias - Criando Jogos de Narrativa a partir de um Template Pré-definido
Authors: Silva Tiago Marino , Verhalen Aline Elias Cardoso , Rodrigues Kamila Rios da Hora
Published: December 2023

Os jogos sérios estão sendo usados em muitas áreas para desenvolver habilidades nos usuários-alvo. Na área da Saúde, jogos sérios são usados para ajudar os pacientes a entender os procedimentos aplicados durante os tratamentos. Quando o paciente é criança, o jogo pode ajudá-lo a compreender o tratamento, além do entretenimento. Este trabalho descreve um jogo sério desenvolvido com o apoio de profissionais de Saúde, visando apoiar o tratamento de crianças com doenças crônicas e com risco de vida. O jogo foi denominado “Narrativa Invertida” porque a criança vai criar a sua narrativa a partir de elementos pré-disponibilizados, tais como balões de fala, objetos e personagens. O objetivo do jogo é permitir que as crianças expressem seus sentimentos por meio da história criada e que os profissionais de Saúde utilizem esse artefato com recursos terapêuticos para iniciar um diálogo ou um procedimento terapêutico.
CAPAihc 2023 - Culturas, Alteridades e Participações em IHC: Tecendo novas tramas em movimento
Authors: Rodrigues Claudia Bordin , Oliveira Leonam Cordeiro de , Oliveira Leander Cordeiro de
Published: December 2023

O segundo Workshop "Culturas, Alteridades e Participações em IHC: Tecendo novas tramas em movimento - CAPAihc2023" dá continuidade a reflexões e problematizações já tecidas em 2017, na e a partir da primeira edição do workshop, no IHC 2017, em Joinville. Este segundo CAPA dá continuidade a temáticas e suporte a pesquisas e projetos de extensão alinhados ao que vem sendo denominado "terceira onda" em IHC, movimento que transcende o mundo do trabalho e da computerização ao articular questões de relevância às esferas privadas, ao cotidiano, aos movimentos populares, as comunidades subalternizadas, diaspóricas, originárias e outras, passando por dimensões feministas e de gênero, de capacidade corporalidade e sexualidade, de origem, moradia, raça e etnia, decolonais e anticoloniais. Interessa neste foro compreender como esse período de seis anos permeado por intercorrências problemáticas no contexto da cultura e da sociedade afetaram as vivências, percepções, projetos e desafios reconhecidos pela comunidade brasileira de IHC alinhadas a terceira onda. Convidamos todas e todos a refletir conosco sobre os movimentos, as tendências, incluindo contradições, disputas, ausências, invisibilizações bordadas nestas redes, onde o físico e o digital se emaranham às atividades humanas e suas interações.
Abordagem para Aprendizado do Simulador gem5 para Pesquisadores Iniciantes
Authors: Rigotto Pedro Corrêa , Freitas Henrique Cota de
Published: December 2023

O simulador gem5 é uma ferramenta com muitos recursos para desenvolvimento de pesquisa em arquitetura de computadores. Ele suporta simulações de sistemas completos, as Instruction Set Architectures (ISAs) mais utilizadas no mercado e diversos tipos de configurações de sistema. É principalmente utilizado por pesquisadores, mas também pode ser utilizado para ensinar arquitetura de computadores a estudantes. Neste artigo, uma abordagem simples é proposta para que iniciantes comecem a utilizar o simulador de maneira rápida e fácil de entender.
Pharmacologic and Natural Therapeutics in Glaucoma Management
Authors: Allison Karen , Morabito Jr Kevin , Patel Deepkumar , W. Montoya Brandon
Published: December 2023

Glaucoma is the leading cause of irreversible blindness worldwide. As diseased population continues to grow, it is important to review both the well-established and recently developed therapeutics available today to best treat this ocular condition. This chapter will discuss the pharmacologic therapies most commonly used to lower intraocular pressure (IOP) in primary open angle glaucoma patients. It will also examine both natural agents and lifestyle modifications that have been shown to have an effect on intraocular pressure. The prostaglandin analog latanoprost, continues to be the most widely accepted first line medication used to treat glaucoma. However, the efficacious, recently developed, Rho-kinase inhibitor Netarsudil, and fixed dose combination of Netarsudil-Latanoprost should continue to increase in utilization. Multiple mechanisms are often used together to treat glaucoma. Fixed dose combination drug therapy has the potential to decrease patient burden, increase compliance, and improve clinical outcomes.
Perspective Chapter: Youth Skills and Unemployment – Perceived Inadequate Soft Skills and Coping Strategies of Employers in Tanzania
Authors: Alfred Kinyondo Abel , Shija Hubert
Published: December 2023

The need to equip the workforce with the relevant knowledge, skills, and abilities (KSAs) to enhance employability and economic development at large has gained momentum, particularly in the developing world. Tanzania has introduced various initiatives to ensure that its workforce is furnished with quality KSAs. Unfortunately, the problem of skills mismatch in Tanzania lingers, particularly that involving soft skills. It is in this context that this study examines soft skills that are inadequate in Tanzania and the preferred coping mechanisms by employers. Using a questionnaire survey, this study reveals that soft skills lacking among graduates in Tanzania include teamwork, communication skills, and language proficiency. Failure to transfer soft skills is attributed to the use of English as a medium of instruction, inadequate number of instructors, lack of competent instructors, lack of training facilities, and the use of outdated facilities. Findings reveal that employers in Tanzania opt to re-train and prolong the probation period for new employees as a coping mechanism. Thus, we first recommend that the government should adopt the education-employment linkage framework in designing, delivering, and updating the curriculum. Moreover, because the preferred coping mechanisms add costs to employers, we recommend that the government either reduce the skills development levy and/or reward employers who do so.
Effect of Sphenopalatine Ganglion Nerve Block on Bleeding and Pain During and After Rhinoplasty and Septoplasty Surgeries: A Double-Blind Randomized Clinical Trial
Authors: Ahmadi Aida , Hosseindoost Saereh , Rahmati Javad , Golparvaran Saeed , Eslami Babak , Pestehei Seyed Khalil
Published: December 2023

Background: The sphenopalatine ganglion nerve block (SPGB) in endoscopic sinus surgeries has been shown to reduce postsurgery narcotic consumption. Objectives: This study aimed to investigate the effect of SPGB on bleeding and pain during and after rhinoplasty and septoplasty. Methods: This study was conducted as a double-blind, randomized clinical trial and included 30 patients who were scheduled for elective rhinoplasty and septoplasty. All the participants received propofol/remifentanil anesthesia and similar intraoperative care. The patients were divided into 2 groups: The SPGB group, which received 0.5% bupivacaine, and the placebo group, which received normal saline. The study compared the amount of narcotics used during and after the operation, pain levels during and after the operation (at 2, 4, 6, and 24 hours after the operation), and bleeding during the operation between the 2 groups. The surgeon's satisfaction with bleeding control was also recorded at 30, 60, and 90 minutes. Results: In the SPGB group, 86% of the participants had ASA (American Society of Anesthesiologists) class I, while in the placebo group, 80% had ASA class I. There was no significant difference in postoperative pain between the control and intervention groups (P > 0.05). However, the SPGB group showed a significant decrease in intraoperative pain based on the amount of narcotics received (P < 0.05). According to the Boezaart criterion, the control group had significantly higher rates of severe and moderate bleeding (P < 0.05), whereas the bupivacaine group had a lower total bleeding rate (P < 0.05). Conclusions: The administration of bupivacaine was effective in reducing pain, bleeding, and the need for narcotics during surgery. The SPGB has the potential to decrease bleeding and drug utilization, making it a preferable option for anesthesiologists aiming to minimize the use of anesthetics.
Previously Diagnosed HIV Infection in Patients with COVID-19 and Advanced HIV Disease Improves Their Survival
Authors: Tsygankova Anna Eduardovna , Gerasimov Andrey Nikolaevich , Chulanov Vladimir Petrovich , Darvina Olga Valerievna , Umbetova Karina Turakbaevna , Malov Valerii Anatolevich , Volchkova Elena Vasilevna
Published: December 2023

Background: Currently, the global HIV epidemic remains ongoing, with a significant number of patients having undiagnosed advanced HIV disease. Providing medical care to patients with both COVID-19 and advanced HIV disease presents specific challenges due to the simultaneous lung damage caused by the SARS-CoV-2 virus and opportunistic pathogens. Objectives: This study aimed to explain the rationale behind recommending HIV screening for patients with severe COVID-19. Methods: A single-center retrospective cohort study was conducted using electronic medical records from a specialized hospital in Moscow that focused on coinfection with HIV/COVID-19. Among the 3,563 patients hospitalized in the relevant departments during the study period, 408 patients were included based on the inclusion/exclusion criteria. Out of the 408 patients with both COVID-19 and advanced HIV disease, 132 individuals were newly diagnosed with HIV infection, while 276 individuals had a previously established HIV diagnosis. Results: The mortality rate in the group of patients with COVID-19 and advanced HIV disease was 31.7% (95% CI, 27.3 - 36.3%). Among patients with COVID-19 and newly diagnosed advanced HIV disease, the mortality rate was 45.5% (95% CI, 37.1 - 54%), while in the group of patients with previously diagnosed advanced HIV disease, the mortality rate was 25% (95% CI, 20.2 - 30.4%). The proportion of individuals with critical CT-4 lung disease in the first group was 32.3% compared to 9.4% in the second group (P < 0.001). The median CD4+ count was 20 cells/µL in the first group compared with 88 cells/µL in the second group (P < 0.001). Conclusions: The presence of pneumocystis pneumonia increased the risk of death by 2.51 times in patients with COVID-19 and newly diagnosed advanced HIV disease. Additionally, Kaposi's sarcoma increased the risk of death by 1.31 times in the same patient group. Furthermore, the detection of HIV infection for the first time during hospitalization due to COVID-19 in the entire study cohort increased the risk of death by 2.21 times.
Effect of COVID-19 and Air Pollution on the Risk Factors Attributed to COPD, Cardiovascular, and Respiratory Diseases
Authors: Nikmanesh Yousef , Zarea Kourosh , Hatamzadeh Naser , Cheraghi Marya , Taherian Masoume , Jalali Saeid , Tahery Nourolla , Shahriyari Habib Allah , Zhiani Fard Akram , Mohammadi Mohammad Javad
Published: December 2023

Context: A wide range of complications, including chronic respiratory diseases, asthma attacks, cardiovascular diseases (CDs), various cancers (blood, lung, and brain), and even death, can result from air pollution. It is essential to assess the health effects on humans caused by environmental air pollutants and non-communicable diseases (NCDs), including coronavirus disease 2019 (COVID-19). The purpose of this review study was to investigate the synergistic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and air pollutants on the risk factors for chronic obstructive pulmonary disease (COPD), CDs, and respiratory diseases (RDs). Evidence Acquisition: An extensive literature review was conducted. A total of 1 005 articles were retrieved from sources, including Google Scholar, Springer, PubMed, Web of Science, and Springer databases. In the final stage of the literature review, a significant association between mortality related to COVID-19 and air pollution emissions was identified, contributing to the risk factors associated with CDs and RDs. Results: The result showed that air pollution can have synergistic effects on the transmission of SARS-CoV-2 viruses and has an increasing effect on the incidence of RDs [such as SARS and Middle East respiratory syndrome (MERS)] and CDs. According to the findings, exposure to toxic air pollutants, whether chronic or acute, can have severe effects, including a decrease in airway ciliary function, damage to the mucous membrane, reduced air sac elasticity, decreased lung capacity, and an increased risk of CDs. Conclusions: COVID-19 and air pollutants pose a serious threat to human and animal health. Epidemiological studies have shown that in addition to environmental conditions, individual sensitivity plays a key role in the development of conditions such as COPD, CDs, RDs, cancer, and mortality.