bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect Analysis of Different Environmental Disinfection Methods on Reducing Contamination of Surfaces of Omicron Ba.2.2 Variant of Sars-Cov-2 in the Fever Clinic in The Out- Broken of Shanghai
Authors: liu Tingliang , Dong Wenfang , Shen Xiaoyu , Han Feng , Liu Chenxi , Wang Yirou , Xu Xuemei , Wu Yufen , Zhou Sha , Cao Qing
Published: August 2022

To investigate the effect of different environmental disinfection methods on reducing contamination of surfaces (CSS) of omicron BA.2.2 of Sars-Cov-2 in the fever clinic between March 20 to May 30, 2022 and analyze influence and related factors of the CSS. This study includes survey data from 389 positive patients (SPP) and 204 CSS in the fever clinic including the CSS type, the disinfection method; the duration time in the clinic, CT value, name, age, weight, mask type and gender of the SPP. Associations between study variables and specified outcomes were explored using uni-variate regression analyses. Among the 389 SPP, 22 SPP (CRP, 5.66%) caused CSS in the separate isolation room. 219 SPP (56.30%) were male. The mean age of SPP was 4.34±3.92 years old and the mean CT value was 12.44±5.11. In total, sampling times with exposure history were 9952, including 204 (2.05%) of CSS. Among the CSS, the positive rate of flat surface is the highest in either public area (2.52%) or separate isolation room (4.75%). Disinfection methods of Ultraviolet radiation + Chemical can significantly reduce the CSS in either public area (0% vs 4.56%) or separate isolation room (0.76% vs 2.64%) compared with the chemical alone (P＜0.05). Compared with ordinary SPP, the CRP is older (6.04y vs 4.23y) and the male proportion is higher (72.73% vs 55.31%). In particular, it is found that SPP contaminated their surroundings and therefore imposed risks for other people. Environment disinfection should be emphasized in Ultraviolet radiation + Chemical. The findings may be useful to guide infection control practice to omicron BA.2.2 of Sars-Cov-2.
SSTR2 as an anatomical imaging marker and a safety switch to monitor and manage CAR T cell toxicity
Authors: Alcaina Yago , Yang Yanping , Vedvyas Yogindra , McCloskey Jaclyn E. , Jin Moonsoo M.
Published: August 2022

The ability to image adoptively transferred T cells in the body and to eliminate them to avoid toxicity will be vital for chimeric antigen receptor (CAR) T cell therapy, particularly against solid tumors with higher risk of off-tumor toxicity. Previously, we have demonstrated the utility of somatostatin receptor 2 (SSTR2) for CAR T cell imaging, illustrating the expansion and contraction of CAR T cells in tumor as well as off-tumor expansion. Using intercellular adhesion molecule 1-specific CAR T cells that secrete interleukin 12 (IL-12) as a model, herein we examined the potential of SSTR2 as a safety switch when combined with the SSTR2-specific maytansine-octreotate conjugate PEN-221. After rapid elimination of tumors, constitutive secretion of IL-12 led to continuous expansion of CAR T cells, causing systemic toxicity and elevated graft-versus-host disease (GvHD). Treatment with PEN-221 rapidly reduced the abundance of CAR T cells, decreasing the severity of toxicity and GvHD, and led to elongated survival. Our study supports the development of SSTR2 as a single genetic marker for CAR T cells that is readily applicable to humans both for anatomical detection of T cell distribution and an image-guided safety switch for rapid elimination of CAR T cells.
Detection of object analysis with data classification in confidence order
Authors: Pradeep M.
Published: August 2022

Object analysis with the detection of an image, in order to specify the classification might be distributed in the coordinate order for rendering the data movement in the order distributed from the classified image. To distribute the image variable in an coordinate sequence that acquire the order to be achieved in the refinement of data that attain the image, with the distribution order that render the sequence in movement from the other object. Object with the classification order that position the movement with the coordinate relation that distribute the movement order with the image that is notated for classification. With the image that classify the model under the distribution data that analyze the order, with the relation mapped in the specific coordinates, the image that order the function in relation with the coordinate that analyze the image in position from the order. Image that analyze the model under distribution for the order mapped into function. In the Existing system with the use of different probabilistic features to calculate the uncertainity data image in computation. In our Proposed model might require the huge integration of a analyzed image data in the probabilistic data in the order metric
Application of robot-assisted endoscopic technique in the treatment of patent ductus arteriosus in 106 children
Authors: Ying Liyang , Wang Xueke , Liu Xiwang , Tan Zheng , Yu Jiangen , Yang Lijun , Shu Qiang
Published: August 2022

Objective
To evaluate and apply the robot-assisted endoscopic surgical technique for treatment of patent ductus arteriosus (PDA) in children.
Methods
Clinical data of 106 children with PDA who underwent robot-assisted endoscopic operation were retrospectively analyzed from August, 2020 to March, 2022. Demographic and preoperative data were collected, including the patient’s age, weight, diameter of the ductus arteriosus, operation time, length of postoperative hospital stay, postoperative complications and hospitalization cost. The age ranged from 6 months to 12 years with median age of 2.5 years. And the weight ranged from 6.6 kilograms (kg) to 51.6 kg with median weight of 12.5 kg. Patients who received transcatheter PDA closure were also enrolled during the same period. Clinical features and perioperative data were compared between the two groups.
Results
All the 106 cases underwent robotically assisted surgery for PDA ligation. No one was converted to thoracotomy. The length of operation time was 15–84 minutes, with an average of 39.4 minutes. There was no obvious bleeding during the operation. The length of postoperative hospital stays were 1–3 days, with an average of 1.1 ± 0.2 days, which was significantly shorter than that of patients underwent transcatheter approach PDA closure (2.2 ± 0.2 days) (p < 0.05). The average hospitalization costs were US$ 8180 in the 106 patients, which were more expensive than that of ones who received transcatheter procedure (US$ 5076 ± 406) (p < 0.05). Only one case was found to have residual ductus shunt during early postoperative follow-up. One case was found with recurrent laryngeal nerve injury. All the two cases were recovery after 3 months of follow-up. The median duration of follow-up were 12 (1–20) months. No other short-term complications occurred during the follow-up period.
Conclusion
Robotic surgical technique for PDA ligation in children is a safe, effective and reliable surgical method with less trauma, faster recovery and fewer surgical risks. This approach should be considered as an option in children patients requiring PDA ligation.
Machine learning models predict overall survival and progression free survival of non-surgical esophageal cancer patients with chemoradiotherapy based on CT image radiomics signatures
Authors: Cui Yongbin , Li Zhengjiang , Xiang Mingyue , Han Dali , Yin Yong , Ma Changsheng
Published: August 2022

Purpose: To construct machine learning models for predicting progression free survival (PFS) and overall survival (OS) with esophageal squamous cell carcinoma (ESCC) patients. Methods: 204 ESCC patients were randomly divided into training cohort (n=143) and validation cohort (n=61) according to the ratio of 7:3. Two radiomics models were constructed by features which were selected by LASSO Cox model to predict PFS and OS, respectively. Clinical features were selected by univariate and multivariate Cox proportional hazards model (p<0.05). Combined radiomics and clinical model was developed by selected clinical and radiomics features. The receiver operating characteristic (ROC) curve, Kaplan Meier (KM) curve and nomogram were used to display the capability of constructed models. Results: There were 944 radiomics features extracted based on region of interest (ROI) in CT images. There were six radiomics features and seven clinical features for PFS prediction and three radiomics features and three clinical features for OS prediction; The radiomics models showed general performance in training cohort and validation cohort for prediction for prediction PFS (AUC, 0.664, 0.676. C-index, 0.65, 0.64) and OS (AUC, 0.634, 0.646.C-index, 0.64, 0.65). The combined models displayed high performance in training cohort and validation cohort for prediction PFS (AUC, 0.856, 0.833. C-index, 0.81, 0.79) and OS (AUC, 0.742, 0.768. C-index, 0.72, 0.71) Conclusion: We developed combined radiomics and clinical machine learning models with better performance than radiomics or clinical alone, which were used to accurate predict 3 years PFS and OS of non-surgical ESCC patients. The prediction results could provide a reference for clinical decision.
Development and validation of a novel HER2RI assay for predicting the risk of recurrence and survival in HER2-positive early breast cancer
Authors: Kang Yikun , Chen Keyu , Gao Singlin , Wang Xiaojia , Wang Xue , Yue Jian , Wang Ouchen , Li Jianmin , Wang Huimin , Chen Tinghao , Du Furong , Cao Shangzhi , Xu Binghe , Yuan Peng
Published: August 2022

De-escalated or escalated systemic therapy remains to be a controversial topic for HER2-positive early breast cancer. Here we presented a novel assay for predicting the relapse risk and survival in HER2-positive early breast cancer. The prognostic models based on the 20-gene signature (HER2RI model) and 20-gene signature combined with nodal stage (HER2RIclin model) were built using random forest, respectively. Totally 254 patients were used for training the models, and two independent cohorts for validating the accuracy. The HER2RI presented a better predictive accuracy than the HER2RIclin. Compared with high-risk patients, the low-risk patients stratified by the HER2RI showed a better 7-year relapse-free survival (RFS) rate. Multivariate analysis further confirmed the high risk stratified by the HER2RI was a significant risk factor for RFS. Overall, the HER2RI assay is predictive of the relapse risk in HER2-positive early breast cancer and can help the patient risk stratification to aid the treatment decisions.
Exercise induced Brugada Pattern and Ventricular Tachycardia during Capecitabine Treatment
Authors: Strobel George , Ponamgi Shiva P. , Roka Attila , Aboeata Ahmed SA
Published: August 2022

We report the case of a 59-year-old female patient with no previous cardiovascular disease treated for Breast cancer with Capecitabine. Shortly after starting treatment, she developed recurrent angina. An exercise stress echocardiogram was performed, which induced a type 1 Brugada pattern twelve seconds of a non-sustained pleomorphic ventricular tachycardia ensued.
Sequences behavior and applications
Authors: Drissi Driss
Published: August 2022

Let j be a fixed integer. Let {xn} be a sequence of complex numbers and let ∆xj = xj+1 -xj. Let 0 < α < 1, first, it is shown that (a) |xn| = O(eϵnα) as n → ∞ for all ϵ > 0, and (b) |Δnxj |1/n→ 0 as n → ∞, if and only if there exists a positive constant R such that ||Δnxj || ≤ Rnnn(1- 1/a). Second, we present an extended version of our result [3], where the condition on the growth of the sequence is replaced by the same condition on the Cesaro means Mn(xn) and retaining the conclusion. Applications to the orbits of operators are given.This helps to elucidate and improve former results of Mbekhta-Zemánek, Atzmon
Using Multiple Choice Questions to Evaluate the Difficulty and Long-Term Retention of Factual Versus Conceptual Knowledge
Authors: Haycocks Neil G. , Hernandez-Moreno Jessica , Bester Johan C. , Hernandez Robert , Kalili Rosalie , Samrao Daman , Simanton Edward , Vida Thomas A.
Published: August 2022

Multiple choice questions (MCQs) are the mainstay of examinations for medical education, physician licensing, and board certification. MCQs are traditionally a preferred way to test rote recall of memorized facts. Their utility in assessing higher cognitive functions has been more problematic to determine. We classified a series of 43 MCQs into two groups to test recall/verbatim thinking and conceptual/inferential thinking, respectively. The MCQs were used to test two related hypotheses 1) scores for recall/verbatim questions would be significantly higher than scores for inferential questions and 2) memory loss would be more rapid for factual minutiae compared to loss in the ability to critically reason about concepts. The MCQs were first used on a summative exam in 2020, which served as a retrospective benchmark of their performance characteristics. The same questions were readministered to volunteers (n = 56) from the same cohort of students in 2022. Retrospective analysis showed the recall/verbatim questions were indeed answered correctly more often than the concept/inference questions (82.0% vs. 60.9%, P = 0.002). Per quartile, only the concept/inference questions showed a significant decline in performance. Two years later, the performance decline was significant for recall/verbatim questions (P < 0.001) but not concept/inference questions (P = 0.050). Analysis of subgroups showed a general convergence of performance on both question types, indicating regression to a baseline mean that may be influenced by the clinical applicability of the material. These findings suggest that conceptual/inferential thinking is more difficult than rote memorization, but the knowledge acquired is more durable, especially if it is reinforced in clinical settings.
Pathological and oncological outcomes of pylorus-preserving versus conventional distal gastrectomy in early gastric cancer: A systematic review and meta-analysis
Authors: Hou Sen , Liu Fan , Gao Zhidong , Ye Yingjiang
Published: August 2022

Background: Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery for the treatment of early gastric cancer (EGC) in the middle third of the stomach. According to the literature reports, PPG decreased decreases the incidence of dumping syndrome, bile reflux, gallstone formation, and nutritional deficit in comparisoned with conventional distal gastrectomy (CDG). However, the debates about PPG has have been dominated by the incomplete lymphadenectomy and oncological safety. We carried out a systematic review and meta-analysis to evaluate the pathological and oncological outcomes of PPG.Methods: The protocol was registered in PROSPERO under number CRD42022304677. Databases including PubMed, Embase, Web of science Science and the Cochrane Register of Controlled Trials were searched before February 21,2022. The outcomes included the pooled odds ratios (ORs) for dichotomous variables and weighted mean differences (WMDs) for continuous variables. For Aall outcomes, were 95% calculated with 95% confidence intervals (CiCIs) were calculated. Meta-analysis was performed using STATA software (Stata 14, Stata Corporation, Texas) and Review Manager 5.4. Results: A total of 4500 patients from 16 studies were included. Compared with the CDG group, the PPG group has had less fewer lymph nodes harvested (WMD=-3.09; 95% CI -4.75 to -1.43; P<0.001). Differences of in the number of resected lymph nodes were observed in at stations No.5, No.6, No.9 and No.11p stations. There were no differences in lymph nodes metastasis of at each station. Shorter proximal resection margins (WMD= -0.554; 95% CI, -0.999 to -0.108; P=0.015) and distal resection margins (WMD= -1.569; 95% CI -3.132 to -0.007; P=0.049) were observed in the PPG group. There were no significant differences in pathological T1a stage (OR=0.99; 95% CI 0.80 to 1.23; P=0.88), T1b stage (OR=1.01; 95% CI 0.81 to 1.26; P=0.88), N0 stage (OR=0.97; 95% CI 0.63 to 1.48; P=0.88), tumor size (WMD = -0.10; 95% CI, -0.25 to 0.05; P = 0.187), differentiated carcinoma (OR=1.04; 95% CI 0.74 to 1.47; P=0.812) or signet ring cell carcinoma (OR=1.22; 95% CI 0.90 to 1.64; P=0.198). No significant differences were observed between the groups in terms of overall survival (HR=0.63; 95% CI 0.24 to 1.67; P=0.852HR=0.22 95%CI 0.01 to 6.69; P=1.000) and or recurrence recurrence-free survival (HR=0.29; 95% CI 0.03 to 2.67; P=0.900HR=0.31; 95%CI 0.00 to 24.35; P=0.687)..Conclusions: The meta-analysis of existing evidence demonstrated that PPG the survival outcomes of PPG may be had comparable survival outcomes withto those of CDG. However, PPG harvested lessfewer lymph nodes at stations in No. 5, No. 6, No. 9 and No. 11p were harvested with PPG stations. We also found that PPG has shorter proximal resection margins and distal resection margins for PPG, meaning more remnant stomach would be preserved in PPG.
Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses
Authors: Fernández-Pato Asier , Sinha Trishla , Gacesa Ranko , Gois Milla F. Brandao , Gelderloos-Arends Jody , Jansen Dianne B.H. , Jaeger Martin , Joosten Leo A.B. , Netea Mihai G. , Weersma Rinse K. , Wijmenga Cisca , Harmsen Hermie J.M. , Fu Jingyuan , Zhernakova Alexandra , Kurilshikov Alexander
Published: August 2022

Background: Interest in microbiome research has increased exponentially in recent years. However, the growth in the number of studies has outpaced the standardization of the processing and analysis of microbiome samples. This lack of standardization represents a major limitation that hampers the replication of results across studies and the clinical translation of research findings. The major source of variation in microbiome results on the experimental side are differences in the methods of DNA extraction from fecal samples. In this study, we aimed to compare the metagenomic profiles obtained by using two commercially available DNA extraction kits, and their effects on microbiome diversity, composition and associations to phenotypes. Methods and Results: We compared two commonly used DNA extraction kits, the AllPrep DNA/RNA Mini Kit (APK) and the QIAamp Fast DNA Stool Mini Kit (FSK), in 745 paired samples from two independent population cohorts: Lifelines-DEEP (LLD, n = 292), and 500 Functional Genomics project (500FG, n = 453). We evaluated the performance of both methods for DNA yield and quality and explored whether the DNA extraction protocol introduces heterogeneity in microbiota composition and diversity or in phenotype–microbiome associations. In both cohorts, APK protocol yields a higher DNA concentration and alpha diversity, with 25% and 10% more bacterial species being detected in comparison to the FSK method in LLD and 500FG cohorts, respectively. Both extraction kits result in markedly different community composition and microbial abundances, with >80% of species being differentially abundant in both cohorts. Species belonging to Firmicutes and Actinobacteria show increased abundances in the APK protocol, whereas Bacteroidetes and Proteobacteria are more prevalent in FSK samples. These differences lead to significant variations in the phenotypic association profile with gut microbes.Conclusions: The results of this study further reinforce that choice of DNA extraction method impacts metagenomic profile of human gut microbiota. We demonstrate that accounting for differences in fecal sample processing is essential for improving the reproducibility of microbiome research findings.
Comparing performance of classification algorithms to use for grading coffee raw quality by using image processing techniques.
Authors: Bedaso Muktar , Meshesha Million , Diriba Chala
Published: August 2022

This study tries to apply digital image processing techniques towards sample Coffee raw quality value grading. More specifically, this study emphases on comparing performance of classification algorithms to use for grading Coffee raw quality by using image processing methods. To ease experimentation image processing phases are followed, including image acquisition, image preprocessing (image filtering and attribute selection), image analysis (segmentation, feature extraction and classification), and image understanding for raw quality image grading. Artificial Neural Network, support vector machine and K-Nearest neighbor classifiers on each classification parameter of morphology, color and the mixture of the two has been made. Experimental outcomes confirm that Artificial Neural Network classifier generated the highest performance of 89.45% accuracy as compared to support vector machine (with 83.75%) and K-Nearest neighbor classifier (with 77.85%). Thus, suitable selection of image processing and classification techniques paves the way for higher accuracy in the higher-level process for decision making.
Green synthesis and characterization of gold nanoparticles for optical biosensing applications
Authors: Rodrigues Eloise P. , Melo Arthur A. , Vasconcelos Jomar S. , Medeiros Eliton S. , Oliveira Leiva C. , Lima Antonio M.N.
Published: August 2022

The goal of the current study is to show how to use green synthesis to create gold nanoparticles, and present a method to determine the dielectric constant of nanoparticles solutions that are used in optical biosensing applications. Green tea (Camellia sinensis) leaf extract was used as a reducing agent to obtain nanoparticles. The gold nanoparticles were synthesized for different concentrations of green tea, directly impacting the particle's size and refractive index. The experimental data from the absorption spectroscopy of colloidal solutions and the zeta test potential were used to determine the dielectric parameters of the gold nanoparticles. Three theoretical expressions proposed for the electrical permittivity have been used to estimate the measured absorption coefficient. The behavior of the estimated absorption coefficient curves is quite similar to the curves obtained from the UV-Vis spectrophotometry. The absolute error of the peak value of the absorption coefficient is less than 1.5\% in the case of the theoretical expression that most accurately describes the dielectric constant of the colloidal solution of gold nanoparticles.
Assessing the impacts of droughts on small ruminants grazing areas and respective soil hydrological responses
Authors: MINEA Gabriel , Ciobotaru Nicu , (Stan) Florentina-Iuliana Mincu , Neculau Gianina , Strat Daniela , Fernández-Gálvez Jesús , Mircea Sevastel
Published: August 2022

Recent studies affirm that climate change is affecting areas worldwide, particularly long droughts, which would transform many fertile territories into degraded areas. This could imply significant impacts and natural hazards influencing both water and soil resources and, subsequently, plant species composition and biodiversity. One of the affected land use and related type of ecosystem are the pastures of the hills with small ruminants (sheep and goats). However, there is a lack of studies aimed to develop integrated hydrological and climate approaches to assess these possible impacts in countries such as Romania. Therefore, this study aims to evaluate drought impacts on hills pastures occupied by small ruminants (SRs) based on the analysis of aridity indices, rainfall simulation experiments, and field surveys (e.g., soil profiles and vegetation transects) in an experimental plot located in the Curvature Subcarpathians of Romania. Preliminary results show high monthly variability of aridity, vertical dehydrated layers in the main soil types (chernozems exhibiting shrinkage and swelling processes), degraded herbaceous vegetation, and high runoff coefficient for bare soils. At the hillslope scale, vegetation, SRs, and water occurrence (e.g., low runoff coefficients and high infiltration rates) are strongly affected by droughts, especially during August and September. The intensification of SRs grazing in these areas (under dry conditions) amplifies the drought effects on the environment (e.g., soil compaction, grass depletion, water scarcity). Our field observations do not support SRs grazing as a major driving factor for land degradation, but unsustainable SRs grazing can drastically induce changes in seasonally available soil water content under arid conditions.
Heterogeneity in the course of suicidal ideation and its relation to suicide attempts in first-episode psychosis: a five-year prospective study
Authors: Sicotte Roxanne , Iyer Srividya N. , Lacourse Eric , Séguin Jean R. , Abdel-Baki Amal
Published: August 2022

Background
Although the risk of suicide is high in first-episode psychosis (FEP), little is known about the course of suicidal ideation and its relation with suicide attempts.
Aims
To identify five-year trajectories of suicidal ideation and associated factors in FEP and compare how suicide attempts were distributed across these identified trajectories.
Method
This five-year prospective study assessed suicidal ideation, suicide attempts and potentially associated factors through research interviews, chart review and coroner's reports in 382 FEP patients [mean age = 23.53(SD = 3.61)] admitted to two five-year early psychosis services in Montreal, Canada. Trajectories were identified using a semiparametric mixture model, and associated factors with multinomial logistic regression.
Results
Three suicidal ideation trajectories were identified : low and decreasing (85.08%); early decline, then increasing (7.85%), and persistent suicidal ideation (7.07%). Suicidal ideation prior to admission (OR = 2.85,p < 0.05) and cocaine use disorder (OR = 6.78,p < 0.05) were associated with the early decline, then increasing suicidal ideation trajectory. Persons with prior suicide ideation (OR = 4.33,p < 0.05) and attempts (OR = 8.18,p < 0.001) and alcohol use disorder (OR = 3.63, p < 0.05) were more likely to belong to the persistent suicidal ideation trajectory, and to attempt suicide during follow-up.
Conclusions
Our study highlights heterogeneity in the course of suicidal ideation over five years and the importance of ongoing assessment of suicidal risk in FEP patients, particularly during periods of transition to other services and for patients who persistently report suicidal ideation, as they are more likely to engage in suicide attempts. Patients with factors associated with increased or persistent suicidal ideation trajectories should be targeted for suicide prevention interventions.
Quarantine and antibiotic susceptibility of Enterobacteriaceae strains and other gram negative bacteria in dairy sweetmeat milk (doodh) peda
Authors: Amreen Fouzia , Puttananjaiah Mohan kumari Honganoor , Viswanath Prema
Published: August 2022

The aim of the present study was to assess the prevalence and isolation of Enterobacteriaceae strains and other gram negative bacteria of milk (doodh) peda-a traditional milk product of India. Bacteria of the family Enterobacteriaceae are the indicator organisms used to provide evidence of poor hygiene, inadequate processing or post-process contamination of foods. A total of 25 peda samples were collected from different places of Mysuru district to evaluate the prevalence of Enterobacteriaceae. Seventeen Gram negative fermentative bacteria of clinical significance were detected, isolated and subsequently identified using API 20E strips method and other associated biochemical tests. Our outcomes indicate that milk peda were contaminated with the Enterobacteriaceae like Enterobacter cloacae, Yersinia bercovieri, Yersinia rohdei, Raoutlella terigena, Acinetobacter lwoffii, Pantoea agglomerans PA2, Klebsiella pneumoniae subsp pneumoniae, Leclericia adecarboxylata, Photorhabdus nematophilus, Enterobacter gergoviae, Acinetobacter baumannii/calcoacetius, Cronobacter sakazaki (Enterobacter sakazaki). Further, the antimicrobial resistant of these Enterobacteriaceae group were also investigated against 20 antibiotics by the disc diffusion assay method. All isolates revealed susceptibility to the fluoroquinones and aminoglycosides, but resistance to the nitrofurantoin (70.59%), augmentin (52.94%), and cefpodoxime (47.06%) antibiotics. Our finding was the first report of prevalence and detection of E. gergoviae in a food sample (milk peda) and examined for antibiotic resistances.
Psychometric properties of an instrument to measure perception of aphrodisiac use among undergraduates in a Southwestern Nigerian University
Authors: Fatade Olawunmi Cecilia , Makinde Gabriel Ifeoluwa , Adebayo Ayodeji Matthew
Published: August 2022

A tool to measure perception of aphrodisiac use by university institution undergraduates was developed and validated. The study was hinged on several theories that could explain potential to use aphrodisiac among the youths. A cross-sectionally designed study that evolved from qualitative and quantitative processes deployed a pretested instrument adapted from literature reviews and expert judgement on 919 students of University of Ibadan sampled through multi-stage method. Exploratory factor analysis was deployed on Polychoric correlation matrix of the items using R-statistical packages. Further model fit analysis was conducted using Confirmatory factor analysis on the items and factors derived from EFA. Mean Z-scores of factors were computed against socio-demographics and symptoms of aphrodisiac use among respondents that have ever used it. Two succession of factor analyses and a structural equation modeling suggested that a first-order model is good fit for experimental data (TLI = 0.931; CFI = 0.948; SRMR = 0.047; RMSEA = 0.083). The four-factor solution to the model included: prolonged sexual performance, use without erectile dysfunction or medical advice, treatment of erectile dysfunction and recreational purposes with an internal consistency that ranged from 0.62–0.92. The validation with socio-demographics and symptoms of aphrodisiac use indicated that: Male respondents, those older than 20years, the married, those from poorly educated parent and sufferers of all identified symptoms had statistically significant differences with poor perception of aphrodisiac use’ domains. This validated instrument is good for assessment of perception of aphrodisiac use among students in tertiary institution albeit with caution. A version of the scale that is broadened with highly refined items and tested for high internal validity is suggested for future studies.
Indigenous Knowledge of Enset (Ensete ventricosum (Welw.) Cheesman) Disease Protection by Gurage People, Southern Ethiopia
Authors: tesfaye henok
Published: August 2022

In Ethiopia, the Enset -based farming system is a major agricultural system that serves at least one-fifth of the country’s population. Farmers locally have received knowledge from generations of experience and experimentation that match neighborhood conditions. Yet, the scientific strategies were less used farmers’ Enset (Ensete ventricosum (Welw.) production and protection. This study aimed at assessing farmer’s indigenous knowledge of protecting their Enset crops form disease. The study adopted multistage sampling methods and a total of 135 respondents were selected. The study identifies, “chegino”, “Janfa”, and “quaqusa” as the major and the most important diseases that counteract the Enset production in the study area. Furthermore, the study indicates the traditional disease prevention methods of the community to control the habitually acknowledged Enset disease. Most farmers in the surveyed area use sanitation (37.8 %) or uprooting of infected Enset plants and Dis-budding (31 %) then burn or bury the residue for reducing the spread of the disease. However, crop rotation and rotation of planting holes were applied by few farmers. Besides, this study shows that the death of experienced older folks, climate variability, farmers moving to other crop production, and lack of help to apply local knowledge is the primary imperatives of the farmers to apply native knowledge on the ranchers in the study area. Thus, farmers' indigenous knowledge can be combined with scientific knowledge to improve livelihood of the farmer.
A novel auxin-inducible degron system for rapid, cell cycle-specific targeted proteolysis
Authors: Capece Marina , Tessari Anna , Mills Joseph , Vinciguerra Gian Luca Rampioni , Louke Darian , Lin Chenyu , McElwain Bryan , Miles Wayne , Coppola Vincenzo , Davies Alexander , Palmieri Dario , Croce Carlo
Published: August 2022

The OsTIR1/auxin-inducible degron (AID) system allows selective protein degradation upon exposure to the phytohormone auxin. However, this technology does not allow to study the effect of acute protein depletion selectively in one phase of the cell cycle. Here, we report a new AID system to Regulate OsTIR1 Levels based on the Cell Cycle Status (ROLECCS) for phase-specific target proteolysis. Finally, we applied the ROLECCS technology to show that the tumor suppressor TP53 plays a S/G2-specific role in suppression of micronuclei accumulation. This new tool allows the analysis of different protein functions during cell cycle progression with unprecedented temporal resolution.
Kommunikationsassistenz in Gesprächssituationen mit Menschen mit komplexem Unterstützungsbedarf
Authors: Niediek Imke
Published: August 2022

In dem Beitrag werden entlang nationaler und internationaler Forschungsbefunde Herausforderungen in der Assistenz von Kindern, Jugendlichen und Erwachsenen, die aufgrund einer Beeinträchtigung mit alternativen und ergänzenden Kommunikationshilfsmitteln kom­munizieren, skizziert. Zentrale These des Beitrags ist der Gedanke, dass es sich bei Kommunikations-Assistenz entgegen dem durch die Empowerment-Bewegung etablierten Assistenzverständnis um eine hoch komplexe Tätigkeit handelt, die nicht nur eine ent­sprechende Haltung, sondern auch spezifisches fachliches und methodisches Know-How erfordert. Es wird ein Vorschlag zur Systematisierung assistierender Gesprächsstrategien vorgestellt und auf das Feld der Unterstützten Kommunikation anhand von exemplarischen Beispielen übertragen.
Abstract
The article presents national and international research findings dealing with challenges in the assistance of children, adolescents and adults who communicate with communication aids. The central thesis of the article is the idea that communication assistance, contrary to the understanding of assistance established by the empowerment movement, is a complex activity that does not only require an appropriate attitude, but also specific technical and methodical know-how. The article presents a proposal for the systematization of assistive conversation strategies and uses examples to transfer them to the field of AAC.
Quantifying Non-Markovianity in Open Quantum Dynamics
Authors: Guo Chu
Published: August 2022

Characterization of non-Markovian open quantum dynamics is both of theoretical and practical relevance. In a seminal work [Phys. Rev. Lett. 120, 040405 (2018)], a necessary and sufficient quantum Markov condition is proposed, with a clear operational interpretation and correspondence with the classical limit.
Here we propose two non-Markovianity measures for general open quantum dynamics, which are fully reconciled with the Markovian limit and can be efficiently calculated based on the multi-time quantum measurements of the system. A heuristic algorithm for reconstructing the underlying open quantum dynamics is proposed, whose complexity is directly related to the proposed non-Markovianity measures. The non-Markovianity measures and the reconstruction algorithm are demonstrated with numerical examples, together with a careful reexamination of the non-Markovianity in quantum dephasing dynamics.
Optimization of oscillation damping modes of spatial double pendulum. I. Formulation of the problem
Authors:   Peter the Great St Petersburg Polytechnic University, Smirnov Alexey S. ,   Institute for Problems in Mechanical Engineering of the Russian Academy of Sciences, Smolnikov Boris A. ,   Peter the Great St Petersburg Polytechnic University,   Institute for Problems in Mechanical Engineering of the Russian Academy of Sciences,
Published: August 2022

The paper discusses the issues of optimal damping of oscillations of a spatial double pendulum, whose joint axes are not collinear to each other. As options for damping, both simply passive damping associated with the influence of viscous friction, and combined passive and active damping are considered, and active influences are formed according to the principle of collinear control. The analytical solution of the system motion equations is given for both cases in the framework of the linear model, and it clearly demonstrates the damping of motions on the natural oscillation modes of the original conservative model. The optimization criteria characterizing the efficiency of the damping processes of system movements are considered. It is noted that in order to obtain the most strongly marked damping modes, the degree of stability should be maximized or the integral energy-time indicator should be minimized. In addition, the main advantages and disadvantages of these optimization criteria are discussed. This article is the basis for further research, which will be presented as a separate article “Optimization of oscillation damping modes of spatial double pendulum. II. Solving the problem and analyzing the results”.
Allocations and legal trends in the 21st century
Authors: Nelson Rebecca L.
Published: August 2022

Around the world, allocating water is a major task of national and sub-national water laws. Although each jurisdiction develops its laws uniquely in response to local conditions, common trends emerge across multiple jurisdictions. The 21st century has seen a geographic broadening of administrative planning and permitting or licensing arrangements for allocating traditional water sources. Allocation regimes also increasingly cover non-traditional water sources that previously fell outside their bounds, including brackish groundwater, rainwater and recycled water. Recognizing interactions between sources is of increasing concern to allocation regimes. Legal developments also provide for an increasing array of water users and other participants in allocation processes. Traditionally, allocation arrangements have centered on significant agricultural, municipal, industrial and other commercial uses. More recently, water law increasingly contemplates granting allocations to, or controlling, uses for environmental purposes and cultural purposes, and broadening access beyond current water rights holders under water market rules. Both constitutional and water laws increasingly recognize a human right to water, and increasingly inclusive processes apply to formulating water plans that guide or influence allocation regimes. These developments are not uniformly present, or present to the same degree, in all jurisdictions. However, encouragingly, they demonstrate increased recognition of the need to respond to water scarcity and give greater attention to equity and inclusion among water users and participants in allocation regimes.
Transitioning away from open access: lessons learnt from a comparative analysis of water allocation regimes worldwide
Authors: Rouillard Josselin , Babbitt Christina , Challies Edward , Rinaudo Jean-Daniel
Published: August 2022

The transition from open to regulated access to water resources is a challenging task for water managers who have to address complex environmental, social and economic trade-offs. Water allocation is a powerful tool, yet its implementation is deeply conflictual. This chapter compares the process of transitioning to regulated access in 13 case studies worldwide. It shows the wide diversity of institutional settings and design choices, while exploring why differences occur and considering the advantages and disadvantages of the different approaches deployed in various contexts. It concludes with key takeaways and reflections on the need for ongoing work assessing the environmental, social and economic performance of allocation regimes.
Economic performance index assessment of an industrial wastewater treatment plant in terms of the European Green Deal: effect of greenhouse gas emissions
Authors: Yapıcıoğlu Pelin , Irfan Yeşilnacar Mehmet
Published: August 2022

This study aims to determine the effect of greenhouse gas (GHG) emissions on economic performance in terms of energy costs for an industrial wastewater treatment plant. Also, the mitigation of GHG emissions aimed at using process modification to obtain possible reductions in energy costs. Optimum energy consumptions were reported for the minimum GHG emission using the Data Envelopment Analysis (DEA) and Monte Carlo simulation model. In this paper, a new empirical approach has been developed depending on the GHG emissions for estimating the economic performance of the wastewater treatment plants. The results revealed that nitrous oxide (N2O) emissions led to the highest energy costs among direct emissions. In the second stage of the study, the effects of design conditions on GHG emissions and energy costs were investigated. If the aeration tank is operated at 24 h of hydraulic retention time (HRT) and 22 days of solid retention time (SRT), then, on average, 27, 27.9, and 30.7% of reduction in energy costs in terms of direct carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) emissions, respectively, is observed in the plant. These reductions corresponded to approximately 17.33 €/kWh of cost-saving in this plant.
A review of the removal of heavy metal ions in wastewater by modified montmorillonite
Authors: Shi Yan , Zhong Songtao , Wang Xin , Feng Changping
Published: August 2022

Heavy metal pollution in water environment has always been a hot issue in environmental pollution research. Among various removal methods of heavy metal pollution, adsorption has attracted attention because of its low cost and low secondary pollution. Montmorillonite is one of an ideal adsorption materials because of its natural pore structure and a high specific surface area. In this review, the modification methods of montmorillonite are introduced. The adsorption effect of different heavy metal ions and the main factors affecting the adsorption are discussed in detail. Meanwhile, the adsorption mechanism is intensively reviewed. The removal of Cr(VI), Cd(II), Pb(II), Cu(II), Cs(I), Co(II), Hg(II), Zn(II), Ni(II), and other nine heavy metal ions by modified montmorillonite was summarized and discussed, and the optimal pH values for different adsorbents were also different, but they were all less than 7, and the removal rates of heavy metal ions by modified montmorillonite under optimal conditions were all greater than 90%. It is concluded that the composite montmorillonite material has a great adsorption potential. Finally, it is proposed that the combination of advanced oxidation and composite montmorillonite material adsorption to remove heavy metal ions is an important direction of adsorption and removal of heavy metal ions in the water environment in the future.
ALGUMAS CONSIDERAÇÕES ESPAÇO-TERRITORIAIS DURANTE A PANDEMIA DE COVID-19
Authors: Lisboa de Vasconcelos Daniel Arthur , Matos Dourado Auceia
Published: August 2022

Este ensaio traz uma reflexão alguns fenômenos espaço-territoriais diretamente relacionados com a rápida e crescente difusão da Covid-19. Para isso, toma-se como referências principais, interpretações geográficas sobre alguns tópicos que emergem no decorrer dessa pandemia, e que têm sido abordados por reconhecidos pensadores contemporâneos, em especial, o britânico David Harvey e o brasileiro Rogério Haesbaert. O texto abordou ainda, de forma generalista, duas evidentes e conectadas realidades espaço-territoriais do atual estágio do capitalismo, marcas desse momento histórico, que têm sido impactadas pela difusão da pandemia: as mobilidades e as contradições socioeconômicas.
Fenomenologia e vocação em Ortega y Gasset
Authors: De Carvalho José Maurício
Published: August 2022

Neste artigo avaliam-se novos estudos sobre a raiz fenomenológica do raciovitalismo. Discute-se a compatibilidade da ética da situação de Scheler com a concepção moral de Ortega, elaborada na chamada primeira navegação. A compreensão de que o pensamento orteguiano teve duas fases reativou esse debate sobre a presença da fenomenologia na segunda navegação. Os novos estudos aprofundam o tema. Conclui-se que a segunda navegação é um aprofundamento das ideias da primeira e que conceitos como vocação e missão podem ser lidos como valores no sentido concebido na primeira navegação, reafirmando, assim, a adesão de Ortega y Gasset à fenomenologia.
Normatividade, experiência e certeza em Wittgenstein
Authors: Teles de Oliveira Wagner
Published: August 2022

No tempo do Tractatus, Wittgenstein compreendia ser a questão cardeal da filosofia a natureza da proposição. O abandono dessa questão torna possível pensar a necessidade lógica não mais por referências à natureza de determinadas proposições, mas com relação à função orientadora das práticas judicativas exercida por determinadas proposições. Isso conduz a obra de Wittgenstein a relativizar a distinção analítico/sintético fundamental ao logicismo. A questão é como a obra de Wittgenstein é capaz de conciliar o caráter revisável da necessidade lógica com a natureza objetiva da expressão da experiência e, além disso, preservar o caráter lógico da certeza num contexto em que a necessidade caracteriza-se pela ausência de fundamentos.
As divergências na interpretação da concepção fregeana de Bedeutung
Authors: Giarolo Kariel Antonio
Published: August 2022

O conceito de Bedeutung é central na filosofia de Frege, entretanto existe uma grande divergência na literatura sobre sua adequada interpretação. Dummet, Sluga, Carl, Burge, Tugendhat e outros comentadores de Frege irão apresentar discordantes interpretações acerca de Bedeutung, as quais se comprometem com aspectos gerais das perspectivas lógico/filosóficas fregeanas. Com base nisso, o objetivo principal do presente artigo é reconstruir a discussão relacionada a interpretação e tradução do conceito fregeano de Bedeutung, visando mostrar que a tradicional caracterização de Bedeutung como referência traz uma série de problemas exegéticos. Por um lado, Bedeutung, entendida enquanto referência, implica que sentenças devam ser compreendidas como tipos especiais de nomes próprios, porém, tal interpretação parece ser incompatível com o chamado princípio de contexto fregeano. Por outro lado, interpretações revisionistas, por sua vez, contravém o suposto realismo de Frege, além de não serem compatíveis com a apresentação encontrada em Über Sinn und Bedeutung.
O que é o neoliberalismo? Isto existe?
Authors: Fleck Amaro
Published: August 2022

Neoliberalismo é um conceito vago e controverso, mas ainda assim crucial para a compreensão de nossa época e da história das ideias políticas, econômicas e sociais do último século. No presente artigo comento os motivos pelos quais este é um termo particularmente controverso (sua adoção foi vacilante; ele denota tanto uma corrente ideológica quanto um conjunto de práticas ou uma etapa histórica; a corrente ideológica possui variações tanto geográficas quanto históricas; a etapa histórica é caracterizada por uma pluralidade de aspectos que nem sempre aparecem juntos), analiso algumas das críticas mais usuais à adoção deste termo e sugiro uma definição capaz de dar conta destas vaguezas, distinguindo com clareza o neoliberalismo enquanto doutrina do neoliberalismo como conjunto de práticas ou etapa histórica.