bluuebunny/crossref_metadata_2025 huggingface dataset:
52 viviendas junto a la autopista
Authors: Ruiz-Allén Ignacio , Ruiz-Esquíroz Josean
Published: October 2022

El proyecto se sitúa en las afueras de Pamplona, aunque bien podría encontrarse en las inmediaciones de cualquier autopista. En este caso, desde las viviendas se disfruta de la visión del nudo que comunica Pamplona con Zaragoza, Barcelona y Madrid, hacia el norte, y Jaca y el Pirineo hacia el Este. La forma del volumen a edificar, alineaciones y alturas, viene dada por un plan urbanístico que pretende mostrar una nueva fachada a la autopista ocultando las "traseras" de los bloques de viviendas que volcaban hacia la carretera N-121, antigua espina dorsal de Navarra. Partimos de un edificio entre medianeras de planta curva, con una profundidad de 15 metros y una altura de baja + 6.El edificio nace con vocación de pantalla de contención que limita por un lado lo infraestructural, marcado por la velocidad, la eficiencia y el lenguaje genérico, y por el otro lo urbano, caracterizado por lo doméstico, lo cotidiano y lo específico.
Hidrógeno y pilas de combustible. Un uso energético eficiente en las viviendas
Authors: Aguado-Alonso Mónica , Alzueta-Ibáñez Beatriz , Garde-Aranguren Raquel
Published: October 2022

En este artículo se da una visión general del hidrógeno y las pilas de combustible y su integración dentro del sector residencial, como una forma de aumentar la eficiencia en el uso de la energía, reduciendo al mismo tiempo las emisiones de efecto invernadero y como alternativa a los combustibles fósiles, incrementando y mejorando la integración de energías renovables mediante el uso del hidrógeno y sus tecnologías.
La estructura. Cubriendo superficies extensas
Authors: Goñi-Lasheras Rufino
Published: October 2022

Uno de los problemas más típicos con que se encuentran mano a mano la ingeniería y la arquitectura es el de la cubrición de grandes superficies sin la intervención de columnas. En ocasiones las columnas ordenarán el espacio y serán útiles como elementos con una doble finalidad: sujetar el forjado y separar los distintos ambientes. Está claro que éste no es el caso: es necesario cubrir los distintos pabellones del edificio sin usar columnas y sin que haya un exceso de estructura. O mejor: que dicha estructura se integre como parte natural del edificio.
Estructuras enterradas y su impermeabilización según el CTE
Authors: Ibáñez-Brugués Carles
Published: October 2022

La introducción del Código Técnico de la Edificación (CTE) ha supuesto una estandarización de la calidad de los proyectos constructivos, lo que conllevará una serie de cambios y aumento de los parámetros de calidad de los mismos. Hasta su entrada en vigor existía una cierta indefinición que comportaba una indefensión tanto de los redactores de los proyectos como de los usuarios finales, ya que los criterios de calidad de la construcción dependía de los criterios dispares de entidades como los Organismos de Control Técnico (OCT) de las compañías de seguros.

El presente artículo analiza los criterios de calidad del CTE en relación con la impermeabilización y drenaje de las cimentaciones de los edificios, incidiendo sobre la naturaleza de los productos a implementar. Asimismo se exponen ciertas observaciones a los planteamientos del CTE para la estanqueización de las estructuras enterradas.
Condensación'92
Authors: Ortega-Andrade Francisco
Published: October 2022

Es cierto que '92 va a ser el signo que caracterice al último cuarto de nuestro siglo e incluso que de personalidad al mundo europeo y con algo de esperanza de elemental soñador, el año en que se arreglen todas las cosas que nuestro país tenga pendiente, pero, no es menos cierto que la humedad de condensación es y será, uno de los problemas que han tomado actualidad y que va a quedar sin resolver en el año en que otros muchos van a solucionarse.

No sólo es un problema actual sino que, por la propia dinámica de los planteamientos fundamentales, la condensación en la edificación tiene todo el aspecto de ir agravándose. Nuestra humedad de condensación tiene sus propias características actuales y no es que antiguamente no se diera este fenómeno de la física de la construcción pero, al menos, no dañaba de manera tan clara a la exigencia del usuario de la edificación.

Como pretendemos dejar constancia, el problema es más actual cuanto mayor es la velocidad de la ejecución de la construcción. Naturalmente, si dicha aceleración se logra a base de acortar los tiempos de puesta en obra y de secado de los materiales, la patología irá en aumento.
La idea germinal
Authors: Araujo Ignacio
Published: October 2022

Nota de Redacción:

Este artículo es el 3.° de una serie iniciada en Revista de Edificación n.º 4.

Esta colección concluirá con la parte cuarta, que aparecerá en RE-7.
Propuesta de un esquema general del proceso del proyecto
Authors: Araujo-Mújica Ignacio
Published: October 2022

Nota de redacción: Este artículo es la cuarta y última parte de una serie publicada por el autor comenzada en RE 4
La construcción en Asiria y Persia
Authors: Ortega-Andrade Francisco
Published: October 2022

ÍNDICE GENERAL

1. La Construcción Mesopotámica.

1.1 Edificación y materiales.

1.2 Los elementos.

1.3 El entorno social tecnológico.

2. La Construcción Persa.

2.1 Edificación y materiales.

2.2 Los elementos.

2.3 La ornamentación.

2.4 El entorno social de la construcción.
Notas sobre el clasicismo Arquitectónico. Pórtico para una introducción
Authors: Lorda-Iñarra Joaquín
Published: October 2022

"Enmudezca y se aparte -lejos, lejos- de nuestros coros.

Quien ajeno a este lenguaje, piensa impuramente,

Quien jamás vio ni danzó en los coros sagrados de las nobles musas.

A éstos digo una, y dos, y tres veces, que se vayan,

Que no tendrán parte en el místico coro. Pero vosotros avivad los cantos,

Los júbilos nocturnos, que acompañaron siempre esta alegre tiesta". (Aristófanes)
Nuevas soluciones para la fijación de aplacados de piedra natural en la edificación actual
Authors: Otero-Cifuentes Antonio
Published: October 2022

ÍNDICE GENERAL

1. La problemática.

2. Principios para una fijación idónea.

3. Soluciones para dicha fijación idónea.

4. Características exigibles a un anclaje idóneo.

5. Cámaras aislantes entre placas y muro soporte.

5.1 Aplacados con fijación por alambre y trasdosado de

mortero.

5.2 Aplacados como cerramiento de cámaras ventiladas

(Aplacados Flotantes).

6. Criterios a tener en cuenta en el diseño de fachada de piedra a efectos de fijación.

6.1 Tamaño de las placas.

6.2 Junta entre placas.

6.3 Espesor de las placas.

6.4 Puntos de fijación.

6.5 Tratamiento de juntas entre placas.

6.6 Disposición de las juntas.

7. Tipos de elemento portante más usuales.

7.1 Fábricas de ladrillo macizo.

7.2 Fábricas de elementos huecos.

7.3 Elementos de hormigón.

8. Sistemas de anclaje industriales.

8.1 Según el elemento soporte.
INCORPORACIÓN DE LAS TECNOLOGÍAS DE LA INFORMACIÓN Y COMUNICACIÓN (TIC) EN ESPACIOS EDUCATIVOS FORMALES BAJO UN ENFOQUE DE INCLUSIÓN SOCIAL
Authors: Pastrana-Muñoz Juan Carlos , Díaz-Díaz Alex Mauricio , Ramos-Lafont Claudia Patricia
Published: October 2022

El presente artículo tiene como propósito analizar la incorporación de las tecnologías de la información y comunicación (TIC) en espacios educativos formales bajo un enfoque de inclusión social, sustentados en las ideas de Burbules (2008),Brunner (2008), Coll y Martí (2001), Hepp (2008), y Martín (2008), entre otros. Se ha desarrollado bajo la metodología de análisis documental enmarcada en el paradigma interpretativo con enfoque cualitativo. Así, es posible decir que se ha realizado unanálisis documental revisando documentos científicos para identificar y analizar estos aspectos. Luego de este proceso metodológico se ha concluido que la configuración de un enfoque de inclusión social garantiza una efectiva incorporación de las tecnologías de la información y comunicación (TIC) en espacios educativos formales. De modo que se requiere de una reflexión amplia y profunda que conduzca a un replanteamiento de los métodos de enseñanza y aprendizaje y sus estructuras clásicas, implicando una transformación del pensamiento conducente al despliegue de acciones que van mucho más allá de la simple incorporación de equipos informáticos en el aula. Palabras clave: TIC, educación, inclusión.
Development of a method for improving the quality of the road surface with the addition of asphalt granulate
Authors: Buzikov Shamil , Motovilova Marina
Published: October 2022

The quality of the road surface is a fundamental criterion during the operation of the roadway. The article considers the issue of wear of the top layer of asphalt concrete coating from the wheels of vehicles during operation. The causes of premature destruction of the road surface have been determined. The physical and mechanical properties of asphalt concrete are presented as strength and deformation indicators.
The goal is to increase the strength characteristics of road surfaces made of hot asphalt concrete mixtures, taking into account the use of the previous asphalt granulate in the formation of the upper layer of the roadway. To achieve this goal, the authors consider the factors affecting the change in strength and deformation characteristics in heavy traffic.
The relevance of this direction lies in the development of public roads and is implemented within the framework of the national project Safe and high-quality highways.
The established operational period of asphalt concrete is ensured by the correct choice of components and components for the formation of a high-quality mixture. The authors of the article consider the possibility of forming a road surface with specified characteristics by regulating the properties of asphalt concrete and its structure using crushed asphalt granulate in the technological process. The dependences of the strength of the dispersed system on the fractional size of the asphalt granulate are presented. The use of granulate in the fractional composition of two standard sizes in a ratio of 50 % to 50 % improves the strength and deformation properties of the roadway, increases the adhesion of the binder and the water resistance of the asphalt concrete coating. According to the results of experimental studies, the technological sequence of the mixture formation with the use of asphalt granulate, as well as its fractional and volumetric composition in the total volume of the mixture is proposed.
EXPERIMENTAL STUDY ON PROPERTIES AND MICROSTRUCTURE OF NANO MODIFIED ULTRAFINE CEMENT-BASED GROUTING MATERIAL
Authors: Han Fenglei , Zhang Zhaoyuan , Liu Yan , Leng Hao , Zhang Xuefu , Liu Tao
Published: October 2022

The traditional cement-based grouting materials commonly used for repairing cracks in highway tunnels have large particle sizes and are easy to block pipes. As such, ultrafine cement-based grouting materials were modified by adding nano-silica (NS), nano-alumina (NA), and carbon nanotubes (CNTs) to improve their grouting, stability, and strength. The results showed that after adding different nano-materials, the fluidity and setting time of the grouting slurry decreased to different degrees, and the maximum values decreased by 41.38% and 42.9%, respectively. Among them, CNTs had the most significant effect, followed by NS. At the same time, the water bleeding rate of the grouting slurry decreased. When 2% NS and 0.5% CNTs were added, water bleeding would not appear. The compressive strength of nano modified grouting materials at all stages would increase first and then decrease with the increase of dosage. The dosages of NS, NA, and CNTs were 1.0%, 1.0%, and 0.1%, respectively, and the compressive strength increased by 24.6%, 4.2%, and 9.2% in 28 days, respectively. X-ray diffraction and scanning electron microscopy tests showed that the surface effect of NS and CNTs can improve the hydration reaction efficiency and hydration products; bridging and nucleation can reduce the crack spacing and structural pores between different particles, and improve the connection between hydration products. The amorphous materials produced by NA can fill the pore structure, while the cementation performance of amorphous materials was poor and had limited contribution to the strength.
DESIGN AND DEVELOPMENT OF SUPER WIDEBAND DIELECTRIC RESONATOR ANTENNA FOR NEXT-GENERATION TELECOMMUNICATIONS
Authors: Kodavanti Pradeep Vinaik , Jayasree P. V. Y. , Bhima Prabhakara Rao
Published: October 2022

The dielectric resonator antenna (DRA) has revolutionized the latest generation of communication systems with their obvious advantages of small size, bandwidth, and power-consuming capabilities. In this paper, an analysis of the impact of the dielectric material on the radiation characteristics of the DRA is presented with simulation reports. The proposed antenna takes the shape of a circular patch with the dielectric resonator having different shapes. This helps to analyze the impact of the tapering adjustments on the features of the antenna. The simulations are performed using the latest version of the complex electromagnetic modeling tool, and results are analyzed in terms of simulated reports like reflection coefficient (S11), voltage standing wave ratio, radiation patterns, and field distribution plots. The overall size of the proposed antenna is 18 × 12 mm2. The measured results are in good agreement with the simulation results. The proposed DRA is suitable for mobile wireless applications.
Plasma Biomarkers Associated to Outcome in Patients with Sars-Cov-2 Infection
Authors: P Venge , S Xu , C Peterson , AK Eriksson , M Hultström , A Larsson , M Lipcsey , S Bülow , R Frithiof
Published: October 2022

Background: A serious consequence of respiratory infections with SARS-CoV-2 is Acute Kidney Injury (AKI). The aim of this study was to evaluate some novel biomarkers measured in plasma for their associations with the outcome of this infection as to AKI and mortality. Methods: Four different HNL (Human Neutrophil Lipocalin) assays were constructed using different antibody configurations, reflecting both neutrophil and epithelial cell activities. TK-1 (Thymidine kinase-1) was measured as a sign of cell destruction and proliferation. For comparison the plasma concentrations of NGAL (Neutrophil Gelatinase Associated Lipocalin), the cytokines IL-6, IL-8 and IFN-γ and of cystatin C, and procalcitonin were also measured. One hundred and three patients with severe respiratory failure admitted to the ICU were sampled for blood at admittance and at day three (n=67) after admittance. Results: Sixty-five percent of the patients developed AKI. The performance of the HNL assay 763/8F was most closely associated to outcome as to AKI and mortality with Area Under the Receiver Operating Characteristics Curve (AUC) of 0.87 and a sensitivity of 80% and a specificity of 88% in COVID-19 patients with and without severe AKI (p<0.0001). TK-1 was significantly related to the development of AKI (p=0.01) and the three cytokines were related to mortality (p=0.004-p<0.001). Conclusion: The HNL variant 763/8F and TK-1 are novel biomarkers that might become useful and novel tools in the management of COVID-19 patients, but likely also in other patients affected by AKI.
İbn Hişâm en-Nahvî’nin Eserlerinde Tercih ve Tenkit İfadeleri
Authors: SARI Fatih
Published: October 2022

Bu çalışmada Arap dili gramerinin öncülerinden İbn Hişâm en-Nahvî’nin (ö. 761/1360) gramere dair eserlerinde kullandığı tercih ve tenkit ifadeleri ele alınmıştır. İbn Hişâm birçok dil meselesi hakkında önceki dilcilerden ve dil ekollerinden nakillerde bulunmuş, herhangi bir ekole taassup derecesinde bağlı kalmamış, aktardığı görüş ve delilleri objektif bir yaklaşımla ele alarak etraflıca tartışmış ve bu görüşler arasında tercihlerde bulunmuştur. Kıyas ve ta’lil metodunu da kullanan müellif, hangi ekole veya dilciye ait olduğuna bakmaksızın delilini güçlü bulduğu görüş ve fikirleri tercih etmiş, zayıf veya isabetsiz gördüğü yaklaşımları ise tenkit ederek gerekçelerini ortaya koymuştur. Naklettiği görüşleri kendi içinde derecelendiren İbn Hişâm, tercihe şayan bulduğu görüşler için sahîh, râcih, savâb, zâhir; tenkit edip terkedilmesi gerektiğini düşündüğü görüşler için de merdûd, bâtıl, fâsid, vehm gibi birbirinden farklı çok sayıda kavram kullanmıştır. Söz konusu kavramların bir kısmını müstakil anlamda kullanmış olmakla birlikte bazılarını yakın veya eş anlamlı olarak da kullanmıştır. Bu çalışmanın amacı, İbn Hişâm’ın başvurduğu söz konusu ifadeleri hangi anlamlarda kullandığını örnekler üzerinden dikkatlere sunarak onun tercih ve tenkit metodu ve diğer dilcilere karşı tutumu hakkında genel bir bakış açısı sunmaktır.
Dinheiro na Mão é Vendaval: Um Caso de Educação Financeira
Authors: Silveira Anderson , Aparecido Reis Luiz , Lana Jailson , Beal Partyka Raul
Published: October 2022

Objetivo e método: Este caso para ensino retrata uma situação financeira familiar de adversidade, o momento quando o provedor deve se aposentar. Mesmo com uma excelente renda mensal, mas sem nunca ter pensado no futuro e utilizando os recursos totais para atender as necessidades imediatas, não promove geração de renda extra para complementar a aposentadoria. O caso adota uma narrativa e diálogos lúdica fictícia, provenientes das experiências e vivências dos autores, porém, com objetivos e acontecimentos reais. Assim, o caso instiga e promove a reflexão dos leitores sobre a importância da educação financeira com todos os aspectos que envolve obter renda, poupar, gastar conscientemente, criar investimentos e, por fim, almejar a esperada aposentadoria sustentável. Resultados e contribuições: O presente trabalho exalta a educação financeira na sua importância para garantir um futuro economicamente viável (e sustentável). Espera-se que o tripé renda, gasto e investimento se torne um círculo virtuoso. O caso para ensino é sugerido para disciplinas como finanças, orçamentos e administração financeira, e outras relacionadas às finanças pessoais e até o ensino transversal.
soulful wisdom of Antonia Darder: the struggle for cultural democracy
Authors: Hernandez Kortney
Published: October 2022

This paper reflects on the life and soulful wisdom of critical pedagogue, Antonia Darder. It is situated as a response to her recent article “Reflections on Cultural Democracy and Schooling” (this issue), and illuminates the authors take on her powerful scholarship and life. In line with the humanizing and emancipatory intent of Darder’s work, this paper will reflect upon salient themes of her work, including: love as a political force, language as a site of struggle, cultural workers in the struggle for freedom, and the impact of her seminal text Culture and Power in the Classroom. Committed to a lifelong culturally democratic political project, Darder’s teachings serve as a guide for educators who take up the call for social justice.
Cultural imperialism and Critical Pedagogy
Authors: Mayo Peter
Published: October 2022

In this paper, I draw inspiration from Antonia Darder’s chosen piece to indicate some of the challenges for a genuinely democratic education and critical pedagogy in these turbulent times. I give pride of place to the war in the Ukraine, targeting the themes of imperialisms in a multipolar world, militarisation, extreme nationalism and Fascism. I also tackle climate change and potential wars in the south resulting from depletion of resources and the related theme of mass migration from ‘South’ to ‘North’. I also tackle the tangible cultural products characterised by social relations marked by human suffering and slavery, these distressing histories carried forward as part of the ‘portability of cultures’ of descendants knocking at the gates of the West.
Transient or Permanent Inhabitants: Cultured Internal Microbiota of Cichlidogyrus thurstonae and Scutogyrus longicornis (Monogenea: Ancyrocephalidae) from Oreochromis sp.
Authors: Ong Zhi-Zhang , Chong Yeak-Heng , Wong Wey-Lim
Published: October 2022

Monogeneans, a class of parasitic platyhelminthes, are usually found on the surface of fish. When it feeds on its host, it harbours bacteria, which can survive in its gut. Occasionally, the monogeneans may cause damages on fish tissue while feeding and may allow secondary infection. The present study aimed to isolate and identify culturable bacteria obtained within the gill monogeneans, Cichlidogyrus thurstonaeand Scutogyrus longicornis, and gill surface of the tilapia fish, Oreochromis sp. based on 16S ribosomal RNA gene sequencing. Monogeneans were isolated from the fish gill filaments and surface disinfected using 70% ethanol before squashed aseptically on Luria Bertani (LB) agar to isolate the internal microbiota. A total of five bacteria species, namely Burkholderia sp., Enterobacter hormaechei, Enterobacter sp., Ochrobactrum intermedium and Pantoea sp., were found within C. thurstonae, whilst a total of eight bacteria species, namely Burkholderia contaminans, Pantoea dispersa, Sphingomonas yabuuchiae, Rhizobium pusense, O. intermedium, Acinetobacter bereziniae, Escherichia hermannii, and Staphylococcus saprophyticus, were found within S. longicornis in which B. contaminans, P. dispersa, and S. yabuuchiaewere also found on the surface of the tilapia fish gill filaments. Enterobacter bugandensisand Acinetobacter pittiiwere found solely on the surface of the gill filaments. These bacteria are also found in the environment and some of them are believed to be pathogenic to fish. We suggest that monogeneans may serve as potential bacteria reservoirs, which facilitate the transmission of bacteria.
Kepelbagaian Makroinvertebrat Bentik di Sungai Jeriau, Bukit Fraser, Pahang, Malaysia
Authors: Hasnoramri Hasya Shazwani , Lau Hor Yue , Ahmad A.K.
Published: October 2022

Sungai Jeriau ialah sungai yang tidak terganggu oleh aktiviti antropogen dan dipercayai mempunyai kualiti air yang baik serta kepelbagaian biologi akuatik yang tinggi. Oleh itu suatu kajian telah dijalankan untuk menilai kualiti air dan kepelbagaian komuniti makroinvertebrat bentik di sungai tersebut serta mengenal pasti makroinvertebrat bentik yang berpotensi sebagai penunjuk biologi di ekosistem tanah tinggi. Persampelan telah dilakukan pada bulan April 2020 dan sebanyak sembilan stesen telah disampel yang mewakili Sungai Jeriau dan salah satu anak sungai yang bersambung dengan Sg. Jeriau. Makroinvertebrat bentik disampel menggunakan jaring Surber dan pengukuran in-situ kualiti air telah dilakukan untuk parameter kekonduksian, pepejal terlarut (TDS), pH, halaju air, suhu dan oksigen terlarut (DO) menggunakan meter YSI 885. Berdasarkan kepada piawaian kualiti air kebangsaan (NWQS), Sungai Jeriau didapati mempunyai kualiti air yang baik dan berada dalam kelas I untuk semua parameter yang dikaji. Ujian Kruskal-Wallis menunjukkan kebanyakan parameter kualiti air berbeza dengan bermakna di antara stesen persampelan (p<0.05, α=0.05) kecuali parameter suhu. Sejumlah 3085 individu makroinvertebrat bentik yang terdiri daripada 1 filum, 2 kelas, 8 order dan 52 famili telah direkodkan di kawasan kajian. Kawasan kajian didominasi oleh famili Elmidae dan Scirtidae (Order:Coleoptera), Baetidae dan Heptageniidae (Order:Ephemeroptera), Hydropsychidae dan Perlidae (Order:Trichoptera) diikuti oleh Tipulidae, Chironomidae dan Simulidae (Order:Diptera). Purata nilai Indeks Kepelbagaian Shannon (H’) adalah 2.56±0.17, Indeks Keseragaman Pielou (J) (0.76±0.09), Indeks Kekayaan Margalef, DMg (4.99±1.72) dan Indeks Reciprocal Berger-Parker (4.54±1.51) yang menunjukkan kualiti ekosistem di antara sederhana tertekan dan baik. Nilai kepelbagaian Shannon rendah disebabkan oleh pendominasian oleh beberapa famili seperti di atas dan pengiraan dilakukan pada aras hirarki taksonomi yang tinggi iaitu famili. Variasi kelimpahan makroinvertebrat bentik di kawasan kajian adalah besar iaitu lebih daripada 70%, dan ujian CCA menunjukkan kekonduksian, suhu dan oksigen terlarut mempunyai pengaruh terhadap famili Elmidae, Chironomidae dan Baetidae. Ujian Monte Carlo menunjukkan terdapat variasi yang signifikan pada paksi–1 CCA (p<0.05) bagi parameter kekonduksian dan oksigen terlarut. Hasil kajian menunjukkan Sg. Jeriau menampung kepelbagaian yang tinggi dan famili Elmidae, Chironomidae dan Baetidae berpotensi sebagai penunjuk biologi ekosistem sungai tanah tinggi.
Characterisation of Tetrastigma rafflesiae Mitochondrial Genes and Assessment of Their Potential as Sequence Markers
Authors: Mohamad Hafizzudin-Fedeli , Abu-Bakar Mohd-Faizal , Mat-Isa Mohd-Noor , A. Latiff A. Latiff , Mohd Firdaus-Raih Mohd Firdaus-Raih , Wan Kiew-Lian
Published: October 2022

Tetrastigma rafflesiae (Miq.) Planch. is a climbing plant species that is known for its unique relationship with holoparasitic plants of Rafflesiaceae. Knowledge on the mitochondrial genes of this species may contribute towards the development of molecular approaches for species identification. This study aims to identify and characterise genes from the T. rafflesiae mitochondrial genome (mitogenome) and assess their potential to discriminate different Tetrastigma species. Mitochondrial-specific sequences were first selected by mapping T. rafflesiae whole-genome sequences to mitogenomes from several reference plant species. De novo assembly of these selected sequences produced a T. rafflesiae mitogenome with a size of 336 kb. Gene annotation revealed that the T. rafflesiae mitogenome contains at least 40 protein coding genes, 20 tRNAs and two rRNAs. Phylogenetic analysis using several mitochondrial genes, namely ccmB, cob, matR, nad6 and rps3 was able to differentiate T. rafflesiae from three other Tetrastigma species, indicating the potential of these genes as species-specific sequence markers. These findings supplement additional genetic information on T. rafflesiae and may aid in the effort of species classification and conservation.
IRE1α Promotes Cell Apoptosis and an Inflammatory Response in Endoplasmic Reticulum Stress-Induced Rheumatoid Arthritis Fibroblast-Like Synovial Cells by Enhancing Autophagy
Authors: Yang Jialiang , Ma Zhenzhen , Jia Qian , Li Yanshan , Lu Yucheng , Yang Qingrui
Published: October 2022

Endoplasmic reticulum (ER) stress can induce autophagy via the unfolded protein response (UPR), and autophagy can regulate the activation of inflammasomes. Inositol-requiring enzyme 1α (IRE1α) is a transducer of the UPR in cells with ER stress. Here, we investigated the role of IRE1α and its impact on ER stress in rheumatoid arthritis fibroblast-like synovial cells (RA-FLSs). RA-FLSs were isolated from rheumatoid arthritis (RA) patients and stimulated with thapsigargin (TG) to produce ER stress cells. ER stress-, autophagy and the expression of apoptosis-associated factors were investigated by western blotting and the qRT-PCR. Cellular ROS levels were assessed by flow cytometry. ELISAs were performed to determine the concentrations of inflammatory mediators. TG treatment promoted IRE1α, GRP78, CHOP, and ATP6 mRNA and protein expression. ROS generation was increased in TG-induced RA-FLSs; additionally, TG was found to induce cell inflammation by upregulating the expression of inflammasome markers and the concentrations of inflammatory mediators. The levels of autophagy markers, apoptosis-associated proteins, and mRNA were increased in TG-stimulated RA-FLSs. However, transfection with si-IRE1α suppressed TG-induced increases in ROS generation, inflammation levels, cell apoptosis, and autophagy in RA-FLSs. Treatment with the autophagy activator RAPA attenuated the protective effects of IRE1α silencing on TG-induced RA-FLS apoptosis and inflammatory damage. Our findings showed that in RA-FLSs, IRE1α silencing alleviated ER stress-induced inflammation and apoptosis caused by autophagy.
Hydroclimatic Data Prediction using a New Ensemble Group Method of Data Handling Coupled with Artificial Bee Colony Algorithm
Authors: Basri Badyalina , Mokhtar Nurkhairany Amyra , Mat Jan Nur Amalina , Marsani Muhammad Fadhil , Ramli Mohamad Faizal , Majid Muhammad , Yaacob Fatin Farazh
Published: October 2022

Linear regression is widely used in flood quantile study that consists of meteorological and physiographical variables. However, linear regression does not capture the complex nonlinear relationship between predictor and target variables. It is rare to find a hydrological application using the group method of data handling (GMDH) model, artificial bee colony (ABC) algorithm, and ensemble technique, precisely predicting ungauged sites. GMDH model is known to be an effective model in complying with a nonlinear relationship. Therefore, in this paper, we enhance the GMDH model by implementing the ABC algorithm to optimize the parameter of partial description GMDH model with some transfer functions, namely polynomial, radial basis, sigmoid and hyperbolic tangent function. Then, ensemble averaging combines the output from those various transfer functions and becomes the new ensemble GMDH model coupled with the ABC algorithm (EGMDH-ABC) model. The results show that this method significantly improves the prediction performance of the GMDH model. The EGMDH-ABC model satisfies the nonlinearity in data to produce a better estimation. Also, it provides more robust, accurate, and efficient results.
Potensi Rizom Serai Acheh (Elettariopsis smithiae) sebagai Punca Tumbuhan Antioksida: Kesan Suhu dan Masa Pengekstrakan terhadap Antioksida, Perubahan Warna dan Sebatian Meruap
Authors: Asari Nur Atiqah , Ab. Halim Syahirah , Mohd Thani Nurfatimah , Hashim Haslaniza
Published: October 2022

Serai Acheh (Elettariopsis smithiae) ialah tumbuhan herba daripada famili Zingiberaceae (Halia) yang digunakan dalam perawatan tradisi. Matlamat kajian ini adalah untuk mengkaji potensi rizom serai Acheh sebagai punca antioksidan semula jadi, mengenal pasti komponen meruap dan menilai perubahan warna yang disebabkan oleh pengekstrakan pada pelbagai parameter. Sampel dikeringkan dalam ketuhar vakum (45 ℃, 0.4 bar) dan diekstrak dengan air suling pada 1:50 (sampel: pelarut) pada pelbagai suhu (50 ℃, 60 ℃, 70 ℃) dan masa (40 min, 80 min, 120 min). Pengekstrakan pada suhu 60 ºC selama 120 minit mencatatkan TPC tertinggi iaitu sebanyak 84.59 mg GAE/g manakala pengekstrakan pada suhu 60 ºC selama 40 minit merekodkan nilai FRAP tertinggi iaitu 1176.4 μM FeII/g berbanding sampel lain. Sampel yang diekstrak pada suhu 70 ºC selama 80 minit mencatatkan peratus penyingkiran radikal DPPH tertinggi iaitu 83.37%, namun begitu tiada perbezaan yang signifikan (p>0.05) berbanding sampel yang diekstrak pada suhu 60 ºC selama 80 minit. Nilai peratus penyingkiran radikal kation ABTS tertinggi iaitu 69.59% juga dicatatkan pada suhu pengekstrakan 60 ºC selama 80 minit. Pengekstrakan rizom serai Acheh pada suhu 60 ºC selama 80 minit adalah yang paling optimum. Kesan perlakuan suhu dan masa pengekstrakan juga menyumbang kepada perubahan warna (ΔE) ekstrak rizom serai Acheh yang signifikan (p<0.05) terhadap sampel kawalan. Sebatian eukaliptol, fensil alkohol, borneol, fensil asetat dan 4-etinil-4,8,8-trimetil-2-metilidenabisiklo [5.2.0] nonana adalah sebatian meruap yang dominan ditemui pada sampel kawalan dan sampel rizom serai Acheh yang telah diekstrak pada keadaan optimum. Kandungan antioksida dan kehadiran sebatian meruap membuktikan bahawa rizom serai Acheh mempunyai potensi sebagai punca antioksida semula jadi dan menjadi alternatif kepada antioksida sintetik.
Aktiviti Antimikrob Selulosa Bakteria daripada Komagataeibacter xylinus menggunakan Minuman Manis Komersial Tamat Tempoh sebagai Punca Karbon
Authors: Ting Jing Yi , Francis Fabiana , Abd Mutalib Sahilah , Mohd Zaini Nurul Aqilah
Published: October 2022

Selulosa bakteria (SB) adalah biopolimer yang penting kepada industri makanan kerana ciri uniknya seperti kapasiti pegangan air (WHC) dan kekuatan mekanikal yang tinggi. SB berpotensi untuk diinovasi dengan penambahan bahan pengawet bagi menyelesaikan masalah pencemaran makanan oleh bakteria patogen. Strain Komagataeibacter xylinus mampu menghasilkan SB yang tinggi melalui proses fermentasi. Namun, proses ini melibatkan penggunaan substrat berkos tinggi. Justeru, penyelidikan ini dijalankan untuk menghasilkan SB daripada punca bernilai rendah seperti minuman manis tamat tempoh dan menilai sifat antimikrob SB terhadap Salmonella Typhi. Fasa pertama kajian, faktor yang mempengaruhi penghasilan SB telah dikaji. Keputusan menunjukkan bahawa hari optimum untuk penghasilan SB adalah pada hari ke-10 fermentasi sebanyak 122.06 g/l. Nilai pH menurun daripada 5.82 pada hari 0 kepada 3.95 setelah 12 hari fermentasi. Kepekatan sukrosa dan protein menurun secara signifikan (p<0.05) sepanjang tempoh fermentasi. WHC bagi SB adalah sebanyak 22.53 g air/g selulosa dan kadar penyerapan air meningkat apabila masa rendaman meningkat. Ujian biodegradasi pula menunjukkan SB basah mengurai lebih pantas (95.85%) berbanding dengan SB kering (68.1%) setelah 8 hari analisis. Pada fasa kedua kajian, SB telah ditambahkan dengan natrium benzoat dan kalium sorbat menggunakan masa rendaman (0.5, 3, 6 dan 24 jam) dan kepekatan yang berbeza (25, 50, 100, 250, 500 dan 1000 mg/mL) dalam keadaan basah dan kering. Keputusan menunjukkan SB mampu menyerap agen antimikrob dan berjaya menghalang pertumbuhan S. Typhi. SB basah menunjukkan zon perencatan terbesar (29 dan 17.5 mm) berbanding dengan SB kering (12 dan 14 mm) pada 24 jam rendaman dalam kepekatan 1000 mg/mL masing-masing untuk larutan natrium benzoat dan kalium sorbat. Kajian ini menunjukkan potensi selulosa bakteria untuk dijadikan sebagai pembungkus aktif bagi memanjangkan jangka hayat makanan.
When Believing in Divine Immanence Explains Vaccine Hesitancy: A Matter of Conspiracy Beliefs?
Authors: Ladini Riccardo , Vezzoni Cristiano
Published: October 2022

This article analyzes the relationship between religiosity and vaccine hesitancy by highlighting the role of a specific dimension of religiosity that makes some people more prone to explaining health conditions as a divine agency—the belief in the immanent presence of the divine in everyday life. Accordingly, these people may undervalue the role of vaccination as a solution to cope with a pandemic and may be more skeptical of vaccines. We suggest a mechanism explaining the relationship between religiosity and vaccine hesitancy by focusing on the mediating role of beliefs in conspiracy theories, given that belief in divine immanence and conspiracy theories share the common trait of attributing agency to hidden forces. Beliefs in conspiracy theories, in turn, have been shown to be among the strongest predictors of vaccine hesitancy. By using a moderated mediation analysis on Italian survey data collected during the Covid-19 pandemic, we show that such a mechanism helps explain the relationship between believing in divine immanence and vaccine hesitancy among people not adhering to institutional religiosity. In contrast, this mechanism does not apply when the immanent conception of the divine is framed within a system of beliefs belonging to institutional religion.
CDK4/6 inhibitors in combination with hormone therapy in clinical practice. Clinical case
Authors: Chekini D. A. , Zeynalova P. A. , Ibragimov E. K. , Kolesnik A. Yu. , Fedenko A. A.
Published: October 2022

Currently, use of CDK4/6 inhibitors in combination with hormone therapy is approved for treatment of patients with advanced or metastatic breast cancer positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2 (HER2). In this clinical observation, analysis of the effectiveness of treatment of a patient with metastatic breast cancer of luminal A subtype is performed. The 1st line combination therapy was CDK4/6 inhibitors (ribociclib) and hormone therapy with aromatase inhibitors (letrozole) and analogues of gonadotropin-releasing hormone (goserelin) with concurrent bone-modifying denosumab therapy. Effectiveness of antitumor drug therapy administered for 7 months, and toxicity of the regimen were evaluated. Effectiveness of the selected combination treatment regimen was demonstrated and confirmed by clinical data, as well as results of laboratory and instrumental examinations. Adverse effects were controlled and managed with symptomatic therapy which allows to continue treatment using previously selected tactics.
Patient noncompliance as the cause of skin toxicity in capecitabine therapy
Authors: Kogoniya L. M. , Borisov K. E. , Ershova K. I.
Published: October 2022

When using capecitabine, manifestations of toxicity in the form of palmar-plantar dysesthesia, redness, excessive sensitivity and peeling of the skin of the palms and feet are well known. However, in the scientific literature available to us, we did not find a single case of skin toxicity with capecitabine, in contrast to targeted therapy, for which skin manifestations are very characteristic. The dermal toxicity described in this paper developed as a result of patient noncompliance. These side effects reduced the adherence to therapy: the next courses of chemotherapy were postponed.
Revisionary systematics of Octocorallia (Cnidaria: Anthozoa) guided by phylogenomics
Authors: McFadden Catherine S. , Van Ofwegen Leen P. , Quattrini Andrea M.
Published: October 2022

The anthozoan sub-class Octocorallia includes over 3500 nominal species of soft corals and gorgonian sea fans, many of which serve as critical foundation species in benthic marine ecosystems in shallow waters to the deep sea. Despite their familiarity and ecological impor-tance, the diversity and taxonomy of octocorals remain poorly known. All of the orders, subordinal groups, and a majority of families have been recognized to be poly- or paraphyletic, but poor resolution of the deeper nodes in mitochondrial or single-locus nuclear gene trees have hindered formal revision of the higher-level taxonomy of the group. We used sequence data from target-capture of 739 ultraconserved and exon loci to reconstruct a fully resolved phylogeny for 185 octocoral taxa represent-ing 55 of 63 currently recognized families. We use this phylogeny, sup-plemented with a gene tree for mitochondrial mtMutS for an additional 107 taxa, to guide a revision of the families and orders of Octocorallia. We (1) elevate the anthozoan sub-classes Octocorallia and Hexacorallia to the rank of Class; (2) replace the three currently recognized orders of Octocorallia (Alcyonacea, Pennatulacea, Helioporacea) with two new orders reflecting reciprocally monophyletic major clades; and (3) revise all families with the exception of the 15 recognized families of sea pens, which we accommodate within a new superfamily. The revised classifi-cation of Octocorallia thus comprises 79 families, including 18 that are newly described and three that have been reinstated or elevated in rank. In addition, two new genera are described and another three reinstated. We leave the family assignment of 46 of 413 genera as incertae sedis until further molecular or morphological data can be obtained to confirm their phylogenetic affinities.
MODERN RUSSIAN BUSINESS ECOSYSTEMS AS A RESULT OF THE DEVELOPMENT OF THE DIGITAL ECONOMY
Authors: Шилов С.А. , Ганина С.А.
Published: October 2022

Рассматриваются некоторые аспекты современной цифровой экономики, в частности, актуальная бизнес-модель – бизнес-экосистемы: их возникновение, характеристики, специфика и выгоды для всех участников и заинтересованных сторон. Анализ проводится на примере крупнейшей отечественной экосистемы «Сбер». Показаны слагаемые экосистемы «Сбер», ее доходы, динамика и направления развития, а также связи с другими российскими бизнес-экосистемами.

Тhe article discusses some aspects of the modern digital economy, in particular the actual business model  – business ecosystems: their emergence, characteristics, specifics and benefits for all participants and stakeholders. The analysis is carried out on the example of the largest domestic ecosystem – the Sber. The components of the Sber ecosystem, its revenues, dynamics and directions of development, as well as connections with other Russian business ecosystems are shown.
ANALYSIS OF INNOVATIONS IN THE LEGAL EDUCATION OF YOUTH
Authors: Божко А.С.
Published: October 2022

Представлен анализ цифровизации правового просвещения и существующих социальных сетей, сформулировано предложение по созданию собственной правовой социальной сети.

Тhe study presents an analysis of the innovation of legal education - the digitalization of legal education. Analysis of existing social networks and a proposal to create your own legal social network.
Assessing the impact of a fixed dose combination of camylofin and mefenamic acid on the onset of pain relief in patients with moderate to severe dysmenorrhea
Authors: Pandey Pragya
Published: October 2022

Background: A fixed-dose combination (FDC) of camylofin 50 mg and mefenamic acid 250 mg was found to be effective and safe following 5 days of treatment in women with primary dysmenorrhea. Here, we assess the onset of analgesia FDC within 24 hours of administration of the FDC using two independent patient-reported outcome tools.Method: In this prospective, single-center study, 140 women with moderate-to-severe primary dysmenorrhea received 3 tablets of the FDC over 24 hours. Primary endpoints were time to pain relief using the 11-point numerical rating scale (NRS-11) and the 100-mm visual analog scale (VAS) and proportion of patients with pain relief in the first 2 hours post-1st dose administration. Pain relief was defined as ≥1-point reduction in pain score on both scales. Secondary endpoints were change in pain intensity scores from baseline to 24 hours post-1st dose using both scales and incidence of adverse events (AEs).Results: Median duration of onset of pain relief using NRS-11 and VAS was 50-and 20-minutes post-1st dose, respectively. Statistically significant reductions (p˂0.0001) post 1st dose was observed from 40 minutes on the NRS-11 and at all post-baseline timepoints on the VAS. Only 3 patients (2.1%) reported treatment emergent AEs, all of which were related to the study drug, ‘mild’ in intensity, and resolved without sequalae.Conclusions: The FDC of camylofin and mefenamic acid provided analgesia onset within 20 min on VAS and 50 min on NRS after administration of first dose and a good safety profile in women with primary dysmenorrhea.
A hysteroscopic view of abnormal uterine bleeding
Authors: Sharma Divya , Mazumdar Mita
Published: October 2022

Background: Abnormal uterine bleeding (AUB) is the most common presenting complaint in reproductive age women. A complete real time visualization of endometrial cavity by hysteroscopy would be the best modality to investigate the etiology of AUB and give targeted treatment to women avoiding unnecessary hysterectomies. Aims and objectives of the study were: to evaluate the diagnostic relevance of hysteroscopy in cases of abnormal uterine bleeding, and to correlate findings on hysteroscopy with ultrasound findings and histopathology of uterine tissue.Methods: A prospective study was undertaken in the department of obstetrics and gynaecology of RKDF Medical College, Bhopal from December 2018 to January 2022. 100 consecutive patients were enrolled in the study. All cases underwent pelvic ultrasound followed by hysteroscopy. Endometrial sampling and histopathological study were done. The findings of ultrasonography, hysteroscopy and histopathology were compared and analyzed.Results: On hysteroscopy among 100 patients’ abnormal findings were documented in 71 patients. In comparison, on histopathology among these 100 cases, a pathology was detected in 64 cases. The most common abnormality detected in the 71 hysteroscopy positive cases was endometrial hyperplasia, in 41 cases. The sensitivity of hysteroscopy was found to be 71.83% with 95% confidence intervals and specificity was found to be 55.17% when compared using histopathology as the gold standard.Conclusions: Hysteroscopy is the gold standard diagnostic modality in the evaluation of AUB as it combines the diagnostic benefits of sonography and histology. In combination, ultrasonography, hysteroscopy with endometrial biopsy can be a potent tool to diagnose gynae pathologies and treat them without resorting to hysterectomy.
O RITO SEGUNDO GIORGIO BONACCORSO
Authors: Silva Daniel Carvalho , Lopes Marlon Ramos
Published: October 2022

BONACCORSO, Giorgio. Rito. Pádua: Edizione Messaggero di Sant’Antonio, 2015. (Col. Parole allo specchio).

Resumo informativo
SOLLICITUDO REI SOCIALIS: Um guia de leitura
Authors: Júnior Francisco Aquino
Published: October 2022

A Carta Encíclica Sollicitudo Rei Socialis do papa João Paulo II foi publicada no dia 30 de dezembro de 1987. Ela foi escrita por ocasião da celebração dos vinte anos da Encíclica Populorum Progressio de Paulo VI e trata da problemática do desenvolvimento dos povos. Retoma e atualiza o ensinamento social desenvolvido naquela encíclica no contexto da segunda metade dos anos de 1980, destacando o aspecto de “continuidade” e de “renovação constante” do ensino ou da doutrina social da Igreja. Em linhas gerais, segue o método ver-julgar-agir: apresenta o “panorama do mundo contemporâneo” (ver); faz uma leitura ético-teológica dessa situação (julgar) e oferece “algumas orientações particulares” (agir). E tem o mérito de assumir e integrar no conjunto da doutrina social da Igreja aspectos fundamentais da reflexão teológico-pastoral da Igreja latino-americana: “estruturas de pecado”, “opção preferencial pelos pobres”, “libertação” como “categoria fundamental” e “primeiro princípio de ação”. Este trabalho, como indica seu subtítulo, pretende ser um “guia de leitura” da encíclica: contextualiza o documento, analisa o texto e destaca aspetos importantes para sua compreensão.
DA PASTORAL DOS MEIOS À INFOPASTORAL:CONSIDERAÇÕES ACERCA DA RECEPÇÃODO DECRETO INTER MIRIFICA
Authors: Moraes Abimar Oliveira de , Durval Gripp Souza Andréia
Published: October 2022

O presente artigo tem como objetivo refletir sobre o processo de recepção criativa do Concílio Vaticano II no campo do diálogo pastoral entre a igreja católica e a Comunicação Social. O Decreto Inter Mirifica, primeiro documento conciliar dedicado à comunicação, representa um passo importante neste campo pastoral. Nele são lançadas as bases que possibilitaram o desenvolvimento de teologias da comunicação e de ações pastorais atentas aos desafios da sociedade marcada pela cultura da comunicação. Contudo, o processo de recepção criativa não pode ser proposto somente a partir deste Decreto. É preciso considerar alguns princípios contidos em outros documentos: Lumen Gentium; Gaudium et Spes; e Ad Gentes. Esta atenção aos outros textos, tem levado a reflexão teológica e a prática pastoral mais recente a uma passagem de uma Pastoral dos Meios ao que no artigo será denominado como Infopastoral.
AS PEQUENAS CIDADES DA AMAZÔNIA SETENTRIONAL: UM ESTUDO SOBRE BONFIM – RR
Authors: Barbosa Tania Maria Sena , Filho Artur Rosa
Published: October 2022

Esta artigo baseia-se em um estudo sobre as pequenas cidades da Amazônia Setentrional no contexto da reprodução do espaço. Diante disso, o objetivo geral foi realizar um estudo sobre a reprodução do espaço urbano nas pequenas cidades da Amazônia Setentrional, destacando a cidade de Bonfim como estudo de caso, no contexto de Roraima. Nessa perspectiva, buscou-se contribuir para o entendimento sobre as pequenas cidades da Amazônia visto que, ainda há poucos estudos sobre elas. Espera-se que esta pesquisa venha contribuir também para entender a natureza e as tendências da hierarquia urbana da região e as novas formas e funções do urbano nas pequenas cidades da Amazônia, aumentando assim, a pesquisa científica nas diferentes linhas, sobretudo na constituição da Ciência Geográfica.