bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring social indicators in smallholder food systems: modeling children’s educational outcomes on crop-livestock family farms in Madagascar
Authors: Thom Amy E. , Bélières Jean-François , Conradie Beatrice , Salgado Paulo , Vigne Mathieu , Fangueiro David
Published: March 2024

Promoting smallholders’ sustainable development in Africa means addressing agronomic and economic factors but also highly relevant social influences shaping farmers’ production and affecting household well-being. Holistic, integrated analyses can help to meet this need, informing more effective policies and interventions for smallholder farming systems. The authors apply a transdisciplinary, quantitative approach to analyzing social impacts in the smallholder context, using milk-producing crop-livestock family farms in central Madagascar as a test case. First, stochastic frontier analysis is leveraged to confirm education as a social indicator linked to production efficiency. Then, linear regression is used for exploratory modeling of children’s educational outcomes. Findings from the Malagasy case emphasize the influence of rural infrastructure, parental education, chronic poverty, family planning, and crop-livestock diversification on children’s educational outcomes among one region’s farming households. Taken together, results suggest that Madagascar’s policymakers should consider comprehensive territorial planning for simultaneously promoting agricultural development and human well-being. This study illustrates how a transdisciplinary approach to social impacts analysis can integrate agronomic, economic, and social dynamics and help anticipate potential outcomes in support of smallholders’ sustainable development.
Factors predicting complications following open reduction and internal fixation of intra-articular distal radius fracture
Authors: Kong Lingde , Li Hua , Zhou Yanqing , Zhang Bing , Han Quan , Fu Meng
Published: March 2024

Objective

This study aimed to determine the incidence and predictors of the complications after open reduction and internal fixation (ORIF) of intra-articular distal radius fracture (IADRF) with a minimum follow-up of 12 months.

Methods

Medical records and outpatient follow-up records were retrospectively reviewed to collect medical, surgical, and complication data on consecutive patients who had undergone an ORIF procedure for an IADRF between January 2019 and June 2022. Data included demographics, comorbidities, injury, surgical characteristics, and laboratory findings on admission. A multivariate logistic regression model was constructed to identify the significant predictors, with a composite of any complications occurring within 12 months after the operation as the outcome variable and potentially a range of clinical data as the independent variables. The magnitude of the relationship was indicated by the odds ratio (OR) and the 95% confidence interval (CI).

Results

During the study period, 474 patients were included, and 64 had documented complications (n = 73), representing an accumulated rate of 13.5%. Among them, carpal tunnel syndrome was the most common, followed by tenosynovitis caused by tendon irritation/rupture, superficial or deep wound infection, complex regional pain syndrome (CRPS) type 1, radial shortening (≥4 mm), plate/screw problems, and others. The multivariate results showed the following factors significantly associated with increased risk of complications: experience of DRF surgery with <30 cases (OR: 2.2, 95% CI: 1.6–3.5), AO type C fracture (OR: 1.7, 95% CI: 1.2–2.9), initial lunate facet collapse of ≥5 mm (OR: 4.2, 95% CI: 1.4–8.9), and use of temporary external fixation before index surgery (OR: 2.4, 95% CI: 1.5–4.3).

Conclusions

These findings may aid in patient counseling and quality improvement initiatives, and IADRF should be directed by an experienced surgeon.
Quantitative Comparative Study on the Performance of a Valve-Controlled Actuator and Electro-Hydrostatic Actuator
Authors: Yang Bo , Lu Yijie , Jiang Haoyi , Ling Zhenfei , Li Tong , Liu Hao , Ouyang Xiaoping
Published: March 2024

The development of the electrification of aircraft has prompted aviation hydraulic systems to shift from traditional centralized valve actuators (CVAs) to electro-hydrostatic actuators (EHAs). In this paper, aiming at the demand for a quantitative comparison of performance between CVAs and EHAs, CVA and EHA prototypes with the same power level and test platform were developed. Then, based on the power flow and dynamic models of the CVA and EHA, simulation and experimental comparative tests were conducted using different load spectrum test conditions and step response test conditions. The comparative test results showed that the efficiency of the EHA was better than that of the CVA, and the dynamic response of the CVA was better than that of the EHA. Finally, a power loss quantification and parameter sensitivity analysis were performed to reveal the impact of different parameters on the different power losses and to provide suggestions for improving the performance of CVAs and EHAs.
Development of New Resolvin D1 Analogues for Osteoarthritis Therapy: Acellular and Computational Approaches to Study Their Antioxidant Activities
Authors: Kariminezhad Zahra , Rahimi Mahdi , Fernandes Julio , Maltais René , Sancéau Jean-Yves , Poirier Donald , Fahmi Hassan , Benderdour Mohamed
Published: March 2024

In osteoarthritis (OA), oxidative stress plays a crucial role in maintaining and sustaining cartilage degradation. Current OA management requires a combination of pharmaceutical and non-pharmacological strategies, including intraarticular injections of hyaluronic acid (HA). However, several lines of evidence reported that HA oxidation by reactive oxygen species (ROS) is linked with HA cleavage and fragmentation, resulting in reduced HA viscosity. Resolvin D1 (RvD1) is a lipid mediator that is biosynthesized from omega-3 polyunsaturated fatty acids and is a good candidate with the potential to regulate a panoply of biological processes, including tissue repair, inflammation, oxidative stress, and cell death in OA. Herein, newly designed and synthesized imidazole-derived RvD1 analogues were introduced to compare their potential antioxidant properties with commercially available RvD1. Their antioxidant capacities were investigated by several in vitro chemical assays including oxygen radical absorbance capacity, 2,2-diphenyl-1-picrylhydrazyl radical scavenging, ferric ion reducing antioxidant power, hydroxyl radical scavenging, and HA fragmentation assay. All results proved that imidazole-derived RvD1 analogues showed excellent antioxidant performance compared to RvD1 due to their structural modifications. Interestingly, they scavenged the formed reactive oxygen species (ROS) and protected HA from degradation, as verified by agarose gel electrophoresis and gel permission chromatography. A computational study using Gaussian 09 with DFT calculations and a B3LYP/6-31 G (d, p) basis set was also employed to study the relationship between the antioxidant properties and chemical structures as well as calculation of the molecular structures, frontier orbital energy, molecular electrostatic potential, and bond length. The results showed that the antioxidant activity of our analogues was higher than that of RvD1. In conclusion, the findings suggest that imidazole-derived RvD1 analogues can be good candidates as antioxidant molecules for the treatment of oxidative stress-related diseases like OA. Therefore, they can prolong the longevity of HA in the knee and thus may improve the mobility of the articulation.
Proactive Braking Control System for Collision Avoidance during Right Turns with Occluded Vision at an Intersection
Authors: Aoki Sota , Fujinami Yohei , Raksincharoensak Pongsathorn , Henze Roman
Published: March 2024

This paper describes the development of an Advanced Driver Assistance System (ADAS) which will allow drivers to avoid collisions with an oncoming vehicle from an occluded area when turning right at intersections in left-hand traffic. Connected vehicles, in coordination with infrastructure, represent one of the commercialized ADAS technologies for collision avoidance. However, the coverage of the ADAS will be limited to designated intersections only, as communication equipment needs to be installed in both the vehicle and infrastructure to enable the assistance. This paper proposes an ADAS using on-board sensors, independent of infrastructure facilities, to control the vehicle velocity to avoid collisions. Most current intersection assistance, by using an Autonomous Emergency Braking System (AEBS), allows the driver to avoid a collision with oncoming vehicles when there is clear vision without occlusion. However, many accidents occur when the vehicle detects the oncoming vehicle too late because of occlusion in the intersection, such as a vehicle in the opposite lane. This system calculates the hazardous speed criteria of the ego vehicle, which might result in a high risk of collision when darting out occurs, and provides speed control assistance to allow the driver to escape from the hazardous speed region. The simulation results reveal that the proposed system effectively reduces the possibility of collisions compared to conventional AEBS.
Investigation of the Phase Composition, Structural, Mechanical, and Dielectric Properties of (1 − x)∙ZrO2-x∙CeO2 Ceramics Synthesized by the Solid-State Method
Authors: Giniyatova Sholpan G. , Shakirzyanov Rafael I. , Garanin Yuriy A. , Sailaukhanov Nurzhan A. , Kozlovskiy Artem L. , Volodina Natalia O. , Shlimas Dmitriy I. , Borgekov Daryn B.
Published: March 2024

Ceramics based on zirconium dioxide are very important compounds for dental, implant, and structural material applications. Despite the fact that tetragonally stabilized YSZ has been well studied, the search for new compositions of zirconia-based ceramics is still in progress. The ZrO2-CeO2 system is one of the alternatives for YSZ materials, but there is conflicting experimental data on its phase composition and mechanical properties depending on the ratio of components. In this study, we investigated the phase composition, and microstructural, mechanical, and physical properties of (1 − x)∙ZrO2-x∙CeO2 (step of x = 0.05) ceramics obtained by the solid-state sintering process from micron-sized powders. For the characterization of samples, XRD, Raman spectroscopy, SEM, the Vickers Microhardness Test, and dielectric spectroscopy were implemented. The results showed that by varying the CeO2 concentration, it is possible to synthesize stable tetragonal ZrO2 at room temperature with a high microhardness HV0.05 value of ~1500, low porosity (~2.5%), and a high dielectric constant of 36. The pronounced combined effect of tetragonal phase formation, densification, and grain size reduction on the mechanical and dielectric properties of the experimental samples was investigated. Refined experimental data make it possible to synthesize high-quality zirconia–ceria ceramics for use as refractories, dispersed nuclear fuel, or solid oxide fuel cells.
Research on Supply Chain Network Resilience: Considering Risk Propagation and Node Type
Authors: Xue Shuaihao , Li Jia , Yu Jiaxin , Li Minghui , Shi Xiaoqiu
Published: March 2024

The aim of this study is to investigate the impact of network characteristics on supply chain network resilience (SCNR) when risk propagation occurs in supply chain networks (SCNs). The network characteristics we study here (e.g., clustering coefficient, scalar index, node type, etc.) are exceptionally important for real-life SCNs, but are not sufficiently considered in the previous research on SCNR. To this end, we first construct an SCN model with adjustable parameters for multiple network characteristics. Second, this SCN model is combined with a susceptible–infectious–susceptible model to construct an SCN risk propagation model. Third, we propose using the average (i.e., a novel SCNR metric considering node type) of the sizes of the maximum connected subgraphs (which contain all node types) over a period of time after risk propagation reaches a steady state. Fourth, the parameters of the SCN model are adjusted to generate SCNs with different network characteristics, and then the resilience of these SCNs is addressed accordingly. The simulation results mainly show the following: the larger the scalar index of an SCN is, the higher its resilience; the larger the clustering coefficient of an SCN is, the smaller its resilience; and the more uniform the distribution of node types is in an SCN, the higher its resilience. Our research work will help optimize SCNs’ structure, which has important implications for society and practice.
A Dynamic Analysis Method of Liquid-Filled Containers Considering the Fluid–Structure Interaction
Authors: Fang Xibing , Bao Xin , Yue Fengjiang , Zhao Qiyuan
Published: March 2024

Based on acoustic fluid elements, a dynamic analysis of liquid sloshing modes and liquid-filled containers was undertaken, considering the effect of fluid–structure interactions (FSIs). The liquid sloshing modes in two-dimensional (2D) and three-dimensional (3D) containers were analyzed, and the results were compared with liquid sloshing modes measured in tests and theoretically calculated modes. This finding thus verifies the correctness of the simulation method based on acoustic fluid elements. Cylindrical liquid-filled containers with different water levels were subjected to a modal analysis and dynamic and time-history analysis. The results show that the finite element analysis (FEA) based on acoustic fluid elements can accurately simulate liquid sloshing modes in liquid-filled containers, as well as the vibration characteristics of these containers with different liquid levels. The vibration frequency of liquid-filled containers decreases with rising liquid levels. The liquid level significantly affects the distribution of the maximum displacement, maximum acceleration, and maximum von Mises stress on the sidewall of liquid-filled containers. Numerical simulations based on acoustic fluid elements provide an effective and reliable method for dynamic analysis of liquid-filled containers considering the effect of FSIs.
Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential
Authors: DeSouza Nicole R. , Nielsen Kate J. , Jarboe Tara , Carnazza Michelle , Quaranto Danielle , Kopec Kaci , Suriano Robert , Islam Humayun K. , Tiwari Raj K. , Geliebter Jan
Published: March 2024

Circular RNAs (circRNAs) are stable, enclosed, non-coding RNA molecules with dynamic regulatory propensity. Their biogenesis involves a back-splicing process, forming a highly stable and operational RNA molecule. Dysregulated circRNA expression can drive carcinogenic and tumorigenic transformation through the orchestration of epigenetic modifications via extensive RNA and protein-binding domains. These multi-ranged functional capabilities have unveiled extensive identification of previously unknown molecular and cellular patterns of cancer cells. Reliable circRNA expression patterns can aid in early disease detection and provide criteria for genome-specific personalized medicine. Studies described in this review have revealed the novelty of circRNAs and their biological ss as prognostic and diagnostic biomarkers.
Individualised Transcranial Magnetic Stimulation Targeting of the Left Dorsolateral Prefrontal Cortex for Enhancing Cognition: A Randomised Controlled Trial
Authors: Martin Donel M. , Su Yon , Chan Ho Fung , Dielenberg Victoria , Chow Esther , Xu Mei , Wang Ashley , Nikolin Stevan , Moffa Adriano H. , Loo Colleen K.
Published: March 2024

Repetitive transcranial magnetic stimulation (rTMS) has been demonstrated to produce cognitive enhancing effects across different neuropsychiatric disorders; however, so far, these effects have been limited. This trial investigated the efficacy of using a novel individualised approach to target the left dorsolateral prefrontal cortex (L-DLPFC) for enhancing cognitive flexibility based on performance on a cognitive task. First, forty healthy participants had their single target site at the L-DLPFC determined based on each individual’s performance on a random letter generation task. Participants then received, in a cross-over single-blinded experimental design, a single session of intermittent theta burst stimulation (iTBS) to their individualised DLPFC target site, an active control site and sham iTBS. Following each treatment condition, participants completed the Task Switching task and Colour–Word Stroop test. There was no significant main effect of treatment condition on the primary outcome measure of switch reaction times from the Task Switching task [F = 1.16 (2, 21.6), p = 0.33] or for any of the secondary cognitive outcome measures. The current results do not support the use of our novel individualised targeting methodology for enhancing cognitive flexibility in healthy participants. Research into alternative methodological targeting approaches is required to further improve rTMS’s cognitive enhancing effects.
The Research on Risk Factors for Adolescents’ Mental Health
Authors: Lin Jiayu , Guo Wuyuan
Published: March 2024

There is a growing tendency for mental health disorders to emerge during adolescence. These disorders impair emotional, cognitive, and behavioral functioning, such as unsatisfying peer relationships, disruptive behavior, and decreased academic performance. They also contribute to vulnerability in later adulthood which negatively influences life-long well-being. Thus, research into etiology is imperative to provide implications for prevention and intervention within family and school practices. It is suggested that the onset of psychological disorders, such as depression and anxiety, is closely related to stress levels and patterns of stress reaction. Therefore, considerable research has investigated the link between hereditary factors, economic status, dispositional vulnerability, social relationships, and stress levels. The current study examines existing evidence and identifies multifaceted risk factors for adolescents’ mental problems across three layers, including individual traits and personality, family status and practices, as well as peer relationships, and school climate. It is also suggested that factors from these three perspectives interact and are closely interconnected, directly or indirectly contributing to adolescent psychopathology. The implications for future development of prevention and intervention programs, as well as therapy, are discussed.
Scopes for Improvements in Energy Conservation and Thermomechanical Performance of Building Blocks in the Kingdom of Bahrain: A Literature Review
Authors: Modi Payal Ashish , Mahmoud Abdelgadir Mohamed , Abakr Yousif Abdalla
Published: March 2024

In regions with hot climates such as Bahrain, the utilization of air conditioning is indispensable in both public and private buildings to attain thermally comfortable indoor environments. External walls, constructed with building blocks, play a crucial role in the heat penetration into the building system. Despite extensive research on the cavity designs of building blocks, there has been a lack of comparison between individual block systems and integrated multi-block systems, considering both thermal and mechanical performance criteria simultaneously. Therefore, it is imperative to gather and review information on key parameters influencing the thermomechanical performance of building blocks, along with investigating techniques used to evaluate these parameters according to international standards. This review primarily focuses on these aspects. Additionally, it presents the historical evolution of housing types and the standard procedures followed by the Bahraini Government and block manufacturing companies in alignment with energy efficiency policies in Bahrain. Ultimately, this review aims to inspire researchers to explore other viable and innovative designs for enhancing the thermal insulation of building walls. By doing so, this work will contribute to Bahrain’s 2030 goals of fostering sustainability and mitigating environmental impact at a local level, while also aligning with the United Nations’ Sustainable Development Goals (SDGs) for 2030, specifically SDG 11, which aims to “make cities and human settlements sustainable”.
Intracranial Efficacy of Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel in Real-World Patients with Non-Small-Cell Lung Cancer and EGFR or ALK Alterations
Authors: Rathbone Marcus , O’Hagan Conor , Wong Helen , Khan Adeel , Cook Timothy , Rose Sarah , Heseltine Jonathan , Escriu Carles
Published: March 2024

Contrary to Pemetrexed-containing chemo-immunotherapy studies, Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel (ABCP) treatment has consistently shown clinical benefit in prospective studies in patients with lung cancer and actionable mutations, where intracranial metastases are common. Here, we aimed to describe the real-life population of patients fit to receive ABCP after targeted therapy and quantify its clinical effect in patients with brain metastases. Patients treated in Cheshire and Merseyside between 2019 and 2022 were identified. Data were collected retrospectively. A total of 34 patients with actionable EGFR or ALK alterations had treatment with a median age of 59 years (range 32–77). The disease control rate was 100% in patients with PDL1 ≥ 1% (n = 10). In total, 19 patients (56%) had brain metastases before starting ABCP, 17 (50%) had untreated CNS disease, and 4 (22%) had PDL1 ≥ 1%. The median time to symptom improvement was 12.5 days (range 4–21 days), with 74% intracranial disease control rates and 89.5% synchronous intracranial (IC) and extracranial (EC) responses. IC median Progression Free Survival (mPFS) was 6.48 months, EC mPFS was 10.75 months, and median Overall Survival 11.47 months. ABCP in real-life patients with brain metastases (treated or untreated) was feasible and showed similar efficacy to that described in patients without actionable mutations treated with upfront chemo-immunotherapy.
Impact of RRP1B Variants on the Phenotype, Progression, and Metastasis of Cervical Cancer
Authors: Balčiūnienė Eglė , Inčiūra Arturas , Juozaitytė Elona , Ugenskienė Rasa
Published: March 2024

Metastasis is a key determinant of cancer progression, influenced significantly by genetic mechanisms. RRP1B, primarily a nucleolar protein, emerges as a suppressor of metastasis, forming alliances with various cellular components and modulating gene expression. This study investigates the involvement of the ribosomal RNA processing 1 homolog B (RRP1B) gene in metastasis regulation in cervical cancer. Through a comprehensive analysis of 172 cervical cancer patients, we evaluated five RRP1B single nucleotide polymorphisms (SNPs) (rs2838342, rs7276633, rs2051407, rs9306160, and rs762400) for their associations with clinicopathological features and survival outcomes. Significant associations were observed between specific genetic variants and clinicopathological parameters. Notably, the A allele of rs2838342 was associated with reduced odds of advanced tumor size, worse prognosis, and, preliminarily, distant metastasis, while the T allele of rs7276633 correlated with a decreased risk of higher tumor size and worse prognosis. Additionally, the C allele of rs2051407 demonstrated protective effects against larger tumors, metastasis, and adverse prognosis. The rs9306160 C allele exhibited a protective effect against metastasis. The rs762400 G allele was significant for reduced tumor size and metastasis risk. Furthermore, the rs2838342 A allele, rs7276633 T allele, rs2051407 C allele, and rs762400 G allele were associated with improved overall survival, demonstrating their potential significance in predicting prognoses in cervical cancer. Linkage disequilibrium and haplotypes analysis enabled us to evaluate the collective effect of the analyzed SNPs, which was in line with the results of allelic models. Our findings underscore the clinical relevance of RRP1B SNPs as prognostic markers in cervical cancer, shedding light on the intricate interplay between genetic factors and disease-progression dynamics. This research provides critical insights for future investigations and underscores the importance of incorporating RRP1B SNP detection into prognostic-assessment tools for accurate prediction of disease outcomes in cervical cancer.
Dilute Alloy Catalysts for the Synthesis of Isobutanol via the Guerbet Route: A Comprehensive Study
Authors: Häusler Johannes , Pasel Joachim , Wöllhaf Clemens , Peters Ralf , Stolten Detlef
Published: March 2024

This study investigates the potential of bimetallic alloy catalysts, specifically Ni99Pt1, Cu99Ni1, Cu99Fe1, Fe99Pt1, and Fe99Pd1, for the synthesis of isobutanol via the Guerbet route. The catalysts were synthesized with a doping of 1 at% Ni, Fe, Pt, and Pd in the base metals Fe, Cu, and Ni. The catalytic properties of these bimetallic alloy catalysts were explored for their potential for promoting the Guerbet reaction. The study aims to test the usability of the theoretically predicted d-band values in the synthesized bimetallic catalysts, which were prepared by means of incipient wetness impregnation, and shows that doping amounts smaller than 1 at% already significantly improved the catalytic activity of the base metals. In particular, the doping of nickel with platinum yielded an effective catalyst for the synthesis of isobutanol via the Guerbet pathway. The Ni99Pt1/C catalyst from the presented experiments had the highest Space Time Yield (STY) and is, therefore, also a promising catalyst for the hydrogen-borrowing reactions class.
MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development
Authors: He Junmin , Wei Chen , Huang Xixia , Zhang Guoping , Mao Jingyi , Li Xue , Yang Cunming , Zhang Wenjing , Tian Kechuan , Liu Guifen
Published: March 2024

Wool is produced and controlled by hair follicles (HFs). However, little is known about the mechanisms involved in HF development and regulation. Sheep dermal fibroblasts (SDFs) play a key role in the initial stage of HF development. Analyzing the molecular mechanism that regulates early HF development in superfine wool sheep is of great importance for better understanding the HF morphogenesis process and for the breeding of fine wool sheep. Here, we show that two microRNAs (miRNAs) affect the development of HFs by targeting two genes that are expressed by SDFs. Meanwhile, the overexpression and inhibition of oar-miR-23b and oar-miR-133 in SDFs cells and cell proliferation, apoptosis, and migration were further detected using a CCK-8 assay, an Annexin V-FITC assay, a Transwell assay, and flow cytometry. We found that oar-miR-23b, oar-miR-133, and their cotarget genes TGFβ2 and NOTCH1 were differentially expressed during the six stages of HF development in superfine wool sheep. Oar-miR-23b and oar-miR-133 inhibited the proliferation and migration of SDFs and promoted the apoptosis of SDFs through TGFβ2 and NOTCH1. oar-miR-23b and oar-miR-133 inhibited the proliferation and migration of SDFs by jointly targeting TGFβ2 and NOTCH1, thereby inhibiting the development of superfine wool HFs. Our research provides a molecular marker that can be used to guide the breeding of ultrafine wool sheep.
Nasopharyngeal Carcinoma Cell Lines: Reliable Alternatives to Primary Nasopharyngeal Cells?
Authors: Makowska Anna , Weiskirchen Ralf
Published: March 2024

Nasopharyngeal carcinoma (NPC) is a type of cancer that originates from the mucosal lining of the nasopharynx and can invade and spread. Although contemporary chemoradiotherapy effectively manages the disease locally, there are still challenges with locoregional recurrence and distant failure. Therefore, it is crucial to have a deeper understanding of the molecular basis of NPC cell movement in order to develop a more effective treatment and to improve patient survival rates. Cancer cell line models are invaluable in studying health and disease and it is not surprising that they play a critical role in NPC research. Consequently, scientists have established around 80 immortalized human NPC lines that are commonly used as in vitro models. However, over the years, it has been observed that many cell lines are misidentified or contaminated by other cells. This cross-contamination leads to the creation of false cell lines that no longer match the original donor. In this commentary, we discuss the impact of misidentified NPC cell lines on the scientific literature. We found 1159 articles from 2000 to 2023 that used NPC cell lines contaminated with HeLa cells. Alarmingly, the number of publications and citations using these contaminated cell lines continued to increase, even after information about the contamination was officially published. These articles were most commonly published in the fields of oncology, pharmacology, and experimental medicine research. These findings highlight the importance of science policy and support the need for journals to require authentication testing before publication.
A Single-Cell Landscape of Spermioteleosis in Mice and Pigs
Authors: Liu Meng-Meng , Fan Chu-Qi , Zhang Guo-Liang
Published: March 2024

(1) Background: Spermatozoa acquired motility and matured in epididymis after production in the testis. However, there is still limited understanding of the specific characteristics of sperm development across different species. In this study, we employed a comprehensive approach to analyze cell compositions in both testicular and epididymal tissues, providing valuable insights into the changes occurring during meiosis and spermiogenesis in mouse and pig models. Additionally, we identified distinct gene expression signatures associated with various spermatogenic cell types. (2) Methods: To investigate the differences in spermatogenesis between mice and pigs, we constructed a single-cell RNA dataset. (3) Results: Our findings revealed notable differences in testicular cell clusters between these two species. Furthermore, distinct gene expression patterns were observed among epithelial cells from different regions of the epididymis. Interestingly, regional gene expression patterns were also identified within principal cell clusters of the mouse epididymis. Moreover, through analysing differentially expressed genes related to the epididymis in both mouse and pig models, we successfully identified potential marker genes associated with sperm development and maturation for each species studied. (4) Conclusions: This research presented a comprehensive single-cell landscape analysis of both testicular and epididymal tissues, shedding light on the intricate processes involved in spermatogenesis and sperm maturation, specifically within mouse and pig models.
The Effect of Heat Treatment on the Microstructure and Mechanical Properties of Plasma-Cladded CoCrFeNiMn Coatings on Compacted Graphite Iron
Authors: Zhang Bo , Fu Ruitao , Gao Peihu , Chen Baiyang , Naumov Anton , Li Fei , Zhao Daming , Yang Zhong , Guo Yongchun , Li Jianping , Cheng Lei , Gong Jinyuan , Liu Jiawei , Li Yu
Published: March 2024

CoCrFeNiMn high-entropy alloy coatings were deposited on compacted graphite iron (CGI) by plasma transfer arc cladding to strengthen and improve the wear resistance (performance) of the surface. The effects of different heat treatment processes on the microstructure and mechanical properties of the CoCrFeNiMn coatings were investigated. Compared with the deposited coating, the single FCC phase in the heat-treated coatings was retained, the grain size of the columnar dendrites decreased, the spacing between the dendrites increased, and the Cr-rich precipitated phase in the grain boundary increased. The heat treatment process had a positive influence on the microhardness and wear resistance of the coatings. The microhardness of the coatings increased after heat treatment. After heat treatment at 660 °C for 90 min, the coating had the highest microhardness of 563 ± 6.9 HV0.2, and it had the best wear resistance.
A New Model of the Limited Availability Group with Priorities for Multi-Service Networks
Authors: Nowak Błażej , Zwierzykowski Piotr
Published: March 2024

In this article, a new analytical model is proposed for a limited-availability group serving a mixture of multiservice BPP (Binomial, Poisson, Pascal) traffic. The model assumes that the different traffic classes belonging to this traffic mixture have priorities that affect their ability to be served. The model includes for the first time the possibility of handling priority traffic through a limited availability group and assumes the possibility of handling priority BPP traffic. The proposed model has been subjected to a number of investigations in which a number of different BPP traffic classes and a number of different priority arrangements have been considered. In this article, the authors present exemplary results of the numerical experiments that illustrate the possible applications of this model to analyze links in a multiservice network. The presented computational results were also compared with the results of simulation experiments, which confirmed the satisfactory accuracy of the proposed model. This allows the model to be easily applied in practice for modeling, analysis, and dimensioning of modern multiservice networks, such as cellular or elastic optical networks.
Fluid–Solid Mixing Transfer Mechanism and Flow Patterns of the Double-Layered Impeller Stirring Tank by the CFD-DEM Method
Authors: Ge Man , Zheng Gaoan
Published: March 2024

The optimization design of the double-layered material tank is essential to improve the material mixing efficiency and quality in chemical engineering and lithium battery production. The draft tube structure and double-layered impellers affect the flow patterns of the fluid–solid transfer process, and its flow pattern recognition faces significant challenges. This paper presents a fluid–solid mixing transfer modeling method using the CFD-DEM coupling solution method to analyze flow pattern evolution regularities. A porous-based interphase coupling technology solved the interphase force and could be used to acquire accurate particle motion trajectories. The effect mechanism of fluid–solid transfer courses in the double-layered mixing tank with a draft tube can be obtained by analyzing key features, including velocity distribution, circulation flows, power, and particle characteristics. The research results illustrate that the draft tube structure creates two major circulations in the mixing transfer process and changes particle and vortex flow patterns. The circulating motion of the double-layered impellers strengthens the overall fluid circulation, enhances the overall mixing efficiency of the fluid medium, and reduces particle deposition. Numerical results can offer technical guidance for the chemical extraction course and lithium battery slurry mixing.
Quality–Cost–Environment Assessment of Sustainable Manufacturing of Photovoltaic Panels
Authors: Gawlik Remigiusz , Siwiec Dominika , Pacana Andrzej
Published: March 2024

This paper aims to develop an integrated Quality–Cost–Environmental (QCE) indicator for the selection of photovoltaic panels (PVps) offered to customers, considering the following criteria: (i) quality satisfaction; (ii) cost-effectiveness; and (iii) environmental impact throughout the life cycle. The proposed QCE indicator was developed within a framework that incorporated an FAHP (Fuzzy Analytic Hierarchy Process), cost-effectiveness analysis (CEA), and life cycle assessment (LCA). The model test confirmed its effectiveness in choosing a PVp which combines environmental friendliness throughout its entire life cycle with satisfactory quality and a reasonable purchase price for customers. The proposed model can be utilized by individuals, businesses, and public entities for the selection of high-quality, cost-efficient, and environmentally friendly PVps—thereby promoting sustainable development.
Evidence for the Use of Karst Tiankengs as Shelters: The Effect of Karst Tiankengs on Genetic Diversity and Population Differentiation in Manglietia aromatica
Authors: Yang Yishan , Tang Jianmin , Zhu Xianliang , Pan Lipo , Zou Rong , Jiang Yunsheng , Wei Xiao
Published: March 2024

Karst tiankengs in China are globally significant locations for studying ecological environments and plant diversity. However, there are few reports on how the unique geographical environment of tiankengs affects plant genetic diversity and genetic structure. This study used Hyper-seq gene sequencing technology to develop large-scale genomic SNPs of Manglietia aromatica, both within and outside the tiankengs. Its aim was to investigate the impact of tiankengs on the genetic diversity and genetic structure of the M. aromatica population. The analysis results indicate that the genetic diversity of the populations within the tiankeng (π = 0.2044) is higher than that of the populations outside of it (π = 0.1671), indicating that the tiankengs have a positive impact on species diversity. The genetic differentiation coefficient (FST) between the populations inside and outside the tiankeng was 0.0534 and the FST values of populations within the tiankeng were 0.077, 0.082, and 0.141, meaning that the genetic variation in the tiankengs is very high. The genetic similarity outside the tiankengs is also very high, indicating that the tiankengs are effectively preserving the genetic diversity of M. aromatica. Furthermore, the gene introgression analysis results gave no proof of gene flow between the three tiankeng populations. This suggests that the tiankengs not only protect species diversity, but also hinder gene flow between populations to some extent. However, this hindrance may gradually subside with the evolution of the tiankengs. The genetic structure analysis revealed that the M. aromatica population in Guangxi, China, can be classified into three subpopulations. The first is the tiankeng subpopulation, including all the populations in tiankengs. The second subpopulation consists of populations surrounding the tiankengs. These two subpopulations are distributed in Leye County in northwestern Guangxi, China, and are very close to each other. The third is the Huanjiang subpopulation, which is located far away from the tiankengs. Considering the direction of gene flow and genetic structure, it is speculated that the populations in the tiankengs evolved from the populations near the pit mouth. This study confirms that the tiankengs are shelters and provide a suitable habitat for the endangered plant M. aromatica, because its genetic diversity is well conserved and the species is well adapted to the habitat within the tiankengs.
Assessing Regional Weather’s Impact on Spinal Cord Injury Survivors, Caregivers, and General Public in Miami, Florida
Authors: Bass Danielle Hildegard , Ghamasaee Pardis , Bigford Gregory E. , Wakefield Mandeville , Duthely Lunthita M. , Samano Daniel
Published: March 2024

(1) Background: Climate change is increasing the already frequent diverse extreme weather events (EWE) across geographic locations, directly and indirectly impacting human health. However, current ongoing research fails to address the magnitude of these indirect impacts, including healthcare access. Vulnerable populations such as persons with spinal cord injury (pSCI) face added physiologic burden such as thermoregulation or mobility challenges like closure of public transportation. Our exploratory research assessed commute and transport to healthcare facilities as well as the knowledge, attitudes and behaviors (KAB) of pSCI regarding EWE and climate change when compared to pSCI caregivers (CG) and the general public (GP). (2) Methods: A KAB survey was employed to conduct a cross-sectional assessment of pSCI, CG, and GP in Miami from October through November 2019 using snowball sampling. Descriptive and logistic regression statistical analyses were used. (3) Results: Of 65 eligible survey respondents, 27 (41.5%) were pSCI, 11 (17%) CG, and 27 (41.5%) GP. Overall, pSCI reported EWE, particularly flooding and heavy rain, affecting their daily activities including healthcare appointments, more frequently than CG or GP. The overall models for logistic regression looking at commute to and attendance of healthcare appointments were statistically significant. pSCI self-report being less vulnerable than others, and a large proportion of each group was not fully convinced climate change is happening. (4) Conclusions: This study provided insight to the KAB of 3 population subgroups in Miami, Florida. pSCI are significantly more vulnerable to the effects of regional weather events yet exhibit disproportionate self-perception of their vulnerability. Continued and more comprehensive research is needed to characterize the barriers that vulnerable populations face during weather events.
Gender-Based Differences in Psychological, Nutritional, Physical Activity, and Oral Health Factors Associated with Stress in Teachers
Authors: Peris-Ramos Helia Carmen , Míguez María Carreira , Rodriguez-Besteiro Stephanie , David-Fernandez Susana , Clemente-Suárez Vicente Javier
Published: March 2024

The aim of this study was to analyze gender differences in stress-related factors among active teachers. A cross-sectional study was conducted to examine gender disparities in psychological, nutritional, physical activity, and oral health factors and how these habits correlate with stress and burnout in their work environment. The sample comprised 1037 teachers from Spain, Colombia, and Chile, consisting of 40.1% men and 59.9% women, with an average age of 41 years and teaching experience of 11.8 ± 9.2 and 12.2 ± 8.7 years, respectively. They were evaluated using a compilation of questionnaires with the objective of analyzing gender differences in habits that are associated with stress levels in teachers. The findings revealed that men had significantly higher levels of depersonalization and personal accomplishment, whereas women exhibited higher levels of perceived stress and conscientiousness. Regarding nutritional habits, results were more positive for women, and men exhibited healthier functional habits by engaging in more weekly sports. Regarding oral health habits, women had better oral hygiene practices, brushing their teeth more frequently. However, women showed a higher tendency to smoke than their male counterparts. We conclude that there are notable gender differences that can provide insights for developing strategies to enhance the overall well-being of teachers.
A Quantum-Safe Software-Defined Deterministic Internet of Things (IoT) with Hardware-Enforced Cyber-Security for Critical Infrastructures
Authors: Szymanski Ted H.
Published: March 2024

The next-generation “Industrial Internet of Things” (IIoT) will support “Machine-to-Machine” (M2M) communications for smart Cyber-Physical-Systems and Industry 4.0, and require guaranteed cyber-security. This paper explores hardware-enforced cyber-security for critical infrastructures. It examines a quantum-safe “Software-Defined-Deterministic IIoT” (SDD-IIoT), with a new forwarding-plane (sub-layer-3a) for deterministic M2M traffic flows. A “Software-Defined Networking” (SDN) control plane controls many “Software-Defined-Deterministic Wide-Area Networks” (SDD-WANs), realized with FPGAs. The SDN control plane provides an “Admission-Control/Access-Control” system for network-bandwidth, using collaborating Artificial Intelligence (AI)-based “Zero Trust Architectures” (ZTAs). Hardware-enforced access-control eliminates all congestion, BufferBloat, and DoS/DDoS attacks, significantly reduces buffer-sizes, and supports ultra-reliable-low-latency communications in the forwarding-plane. The forwarding-plane can: (i) Encrypt/Authenticate M2M flows using quantum-safe ciphers, to withstand attacks by Quantum Computers; (ii) Implement “guaranteed intrusion detection systems” in FPGAs, to detect cyber-attacks embedded within billions of IIoT packets; (iii) Provide guaranteed immunity to external cyber-attacks, and exceptionally strong immunity to internal cyber-attacks; (iv) Save USD 100s of billions annually by exploiting FPGAs; and (v) Enable hybrid Classical-Quantum networks, by integrating a “quantum key distribution” (QKD) network with a classical forwarding plane with exceptionally strong cyber-security, determined by the computational hardness of cracking Symmetric Key Cryptography. Extensive experimental results for an SDD-WAN over the European Union are reported.
Snapshot-Optimal Real-Time Ride Sharing
Authors: Hassan Afzaal , Wallace Mark , Moser Irene , Harabor Daniel D.
Published: March 2024

Ridesharing effectively tackles urban mobility challenges by providing a service comparable to private vehicles while minimising resource usage. Our research primarily concentrates on dynamic ridesharing, which conventionally involves connecting drivers with passengers in need of transportation. The process of one-to-one matching presents a complex challenge, particularly when addressing it on a large scale, as the substantial number of potential matches make the attainment of a global optimum a challenging endeavour. This paper aims to address the absence of an optimal approach for dynamic ridesharing by refraining from the conventional heuristic-based methods commonly used to achieve timely solutions in large-scale ride-matching. Instead, we propose a novel approach that provides snapshot-optimal solutions for various forms of one-to-one matching while ensuring they are generated within an acceptable timeframe for service providers. Additionally, we introduce and solve a new variant in which the system itself provides the vehicles. The efficacy of our methodology is substantiated through experiments carried out with real-world data extracted from the openly available New York City taxicab dataset.
Quantifying Abdominal Coloration of Worker Honey Bees
Authors: Bubnič Jernej , Prešern Janez
Published: March 2024

The main drawback in using coloration to identify honey bee subspecies is the lack of knowledge regarding genetic background, subjectivity of coloration grading, and the effect of the environment. The aim of our study was to evaluate the effect of environmental temperature on the abdominal coloration of honey bee workers and to develop a tool for quantifying abdominal coloration. We obtained four frames of honey bee brood from two colonies and incubated them at two different temperatures (30 and 34 °C). One colony had workers exhibiting yellow marks on the abdomen, while the other did not. We collected hatched workers and photographed abdomens. Images were analyzed using custom-written R script to obtain vectors that summarize the coloration over the abdomen length in a single value—coloration index. We used UMAP to reduce the dimensions of the vectors and to develop a classification procedure with the support vector machine method. We tested the effect of brood origin and temperature on coloration index with ANOVA. UMAP did not distinguish individual abdomens according to experimental group. The trained classifier sufficiently separated abdomens incubated at different temperatures. We improved the performance by preprocessing data with UMAP. The differences among the mean coloration index values were not significant between the gray groups incubated at different temperatures nor between the yellow groups. However, the differences between the gray and yellow groups were significant, permitting options for application of our tool and the newly developed coloration index. Our results indicate that the environmental temperature in the selected range during development does not seem to impact honey bee coloration significantly. The developed color-recording protocol and statistical analysis provide useful tools for quantifying abdominal coloration in honey bees.