bluuebunny/crossref_metadata_2025 huggingface dataset:
Multifunctional NK Cell–Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release
Authors: Klausz Katja , Pekar Lukas , Boje Ammelie Svea , Gehlert Carina Lynn , Krohn Steffen , Gupta Tushar , Xiao Yanping , Krah Simon , Zaynagetdinov Rinat , Lipinski Britta , Toleikis Lars , Poetzsch Sven , Rabinovich Brian , Peipp Matthias , Zielonka Stefan
Published: October 2022

In this work, we have generated novel Fc-comprising NK cell engagers (NKCEs) that bridge human NKp30 on NK cells to human epidermal growth factor receptor (EGFR) on tumor cells. Camelid-derived VHH single-domain Abs specific for human NKp30 and a humanized Fab derived from the EGFR-specific therapeutic Ab cetuximab were used as binding arms. By combining camelid immunization with yeast surface display, we were able to isolate a diverse panel of NKp30-specific VHHs against different epitopes on NKp30. Intriguingly, NKCEs built with VHHs that compete for binding to NKp30 with B7-H6, the natural ligand of NKp30, were significantly more potent in eliciting tumor cell lysis of EGFR-positive tumor cells than NKCEs harboring VHHs that target different epitopes on NKp30 from B7-H6. We demonstrate that the NKCEs can be further improved with respect to killing capabilities by concomitant engagement of FcγRIIIa and that soluble B7-H6 does not impede cytolytic capacities of all scrutinized NKCEs at significantly higher B7-H6 concentrations than observed in cancer patients. Moreover, we show that physiological processes requiring interactions between membrane-bound B7-H6 and NKp30 on NK cells are unaffected by noncompeting NKCEs still eliciting tumor cell killing at low picomolar concentrations. Ultimately, the NKCEs generated in this study were significantly more potent in eliciting NK cell–mediated tumor cell lysis than cetuximab and elicited a robust release of proinflammatory cytokines, both features which might be beneficial for antitumor therapy.
Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis
Authors: Huang Ling , Ma Yilei , Guo Hui , Tang Na , Ouyang Song , Nuro-Gyina Patrick , Tao Lijian , Liu Yusen , O’Brien Matthew C , Langdon Wallace Y , Zhang Jian
Published: October 2022

Akt-1 and Akt-2 are the major isoforms of the serine/threonine Akt family that play a key role in controlling immune responses. However, the involvement of Akt-1 and Akt-2 isoforms in antifungal innate immunity is completely unknown. In this study, we show that Akt2−/−, but not Akt1−/−, mice are protected from lethal Candida albicans infection. Loss of Akt-2 facilitates the recruitment of neutrophils and macrophages to the spleen and increases reactive oxygen species expression in these cells. Treating C57BL/6 mice with a specific inhibitor for Akt-2, but not Akt-1, provides protection from lethal C. albicans infection. Our data demonstrate that Akt-2 inhibits antifungal innate immunity by hampering neutrophil and macrophage recruitment to spleens and suppressing oxidative burst, myeloperoxidase activity, and NETosis. We thus describe a novel role for Akt-2 in the regulation of antifungal innate immunity and unveil Akt-2 as a potential target for the treatment of fungal sepsis.
STAT3 Inhibits Autocrine IFN Signaling in Type I Conventional Dendritic Cells
Authors: Chrisikos Taylor T , Zhou Yifan , Kahn Laura M , Patel Bhakti , Denne Nina L , Brooks Athena , Shen Li , Wang Jing , Watowich Stephanie S
Published: October 2022

Type I conventional dendritic cells (cDC1s) are an essential Ag-presenting population required for generating adaptive immunity against intracellular pathogens and tumors. While the transcriptional control of cDC1 development is well understood, the mechanisms by which extracellular stimuli regulate cDC1 function remain unclear. We previously demonstrated that the cytokine-responsive transcriptional regulator STAT3 inhibits polyinosinic:polycytidylic acid [poly(I:C)]-induced cDC1 maturation and cDC1-mediated antitumor immunity in murine breast cancer, indicating an intrinsic, suppressive role for STAT3 in cDC1s. To probe transcriptional mechanisms regulating cDC1 function, we generated novel RNA sequencing datasets representing poly(I:C)-, IL-10–, and STAT3-mediated gene expression responses in murine cDC1s. Bioinformatics analyses indicated that poly(I:C) stimulates multiple inflammatory pathways independent of STAT3, while IL-10–activated STAT3 uniquely inhibits the poly(I:C)-induced type I IFN (IFN-I) transcriptional response. We validated this mechanism using purified cDC1s deficient for STAT3 or IFN signaling. Our data reveal IL-10–activated STAT3 suppresses production of IFN-β and IFN-γ, accrual of tyrosine phosphorylated STAT1, and IFN-stimulated gene expression in cDC1s after poly(I:C) exposure. Moreover, we found that maturation of cDC1s in response to poly(I:C) is dependent on the IFN-I receptor, but not the type II IFN receptor, or IFN-λ. Taken together, we elucidate an essential role for STAT3 in restraining autocrine IFN-I signaling in cDC1s elicited by poly(I:C) stimulation, and we provide novel RNA sequencing datasets that will aid in further delineating inflammatory and anti-inflammatory mechanisms in cDC1s.
Enhanced IFN Sensing by Aggressive Chronic Lymphocytic Leukemia Cells
Authors: Luo Tina YuXuan , Shi Yonghong , Wang Guizhi , Spaner David E
Published: October 2022

Type I IFN is made by cells in response to stress. Cancer cells exist in a state of stress, but their IFN response is complex and not completely understood. This study investigated the role of autocrine IFN in human chronic lymphocytic leukemia (CLL) cells. CLL cells were found to make low amounts of IFN via TANK-binding kinase 1 pathways, but p-STAT1 and -STAT2 proteins along with IFN-stimulated genes that reflect IFN activation were variably downregulated in cultured CLL cells by the neutralizing IFNAR1 Ab anifrolumab. Patients with CLL were segregated into two groups based on the response of their leukemia cells to anifrolumab. Samples associated with more aggressive clinical behavior indicated by unmutated IGHV genes along with high CD38 and p-Bruton’s tyrosine kinase expression exhibited responses to low amounts of IFN that were blocked by anifrolumab. Samples with more indolent behavior were unaffected by anifrolumab. Hypersensitivity to IFN was associated with higher expression of IFNAR1, MX1, STAT1, and STAT2 proteins and lower activity of negative regulatory tyrosine phosphatases. Autocrine IFN protected responsive CLL cells from stressful tissue culture environments and therapeutic drugs such as ibrutinib and venetoclax in vitro, in part by upregulating Mcl-1 expression. These findings suggest hypersensitivity to IFN may promote aggressive clinical behavior. Specific blockade of IFN signaling may improve outcomes for patients with CLL with higher-risk disease.
RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells
Authors: Zhang Huazhi , Cui Zhihui , Pan Ting , Hu Huijun , He Ruirui , Yi Ming , Sun Wanwei , Gao Ru , Wang Heping , Ma Xiaojian , Peng Qianwen , Feng Xiong , Liang Shuyan , Du Yanyun , Wang Chenhui
Published: October 2022

The receptor tyrosine kinase EPHB2 (EPH receptor B2) is highly expressed in many human cancer types, especially in gastrointestinal cancers, such as colorectal cancer. Several coding mutations of the EPHB2 gene have been identified in many cancer types, suggesting that EPHB2 plays a critical role in carcinogenesis. However, the exact functional mechanism of EPHB2 in carcinogenesis remains unknown. In this study, we find that EPHB2 is required for TNF-induced signaling activation and proinflammatory cytokine production in colorectal epithelial cells. Mechanistically, after TNF stimulation, EPHB2 is ubiquitinated by its E3 ligase RNF186. Then, ubiquitinated EPHB2 recruits and further phosphorylates TAB2 at nine tyrosine sites, which is a critical step for the binding between TAB2 and TAK1. Due to defects in TNF signaling in RNF186-knockout colorectal epithelial cells, the phenotype of colitis-propelled colorectal cancer model in RNF186-knockout mice is significantly reduced compared with that in wild-type control mice. Moreover, we find that a genetic mutation in EPHB2 identified in a family with colorectal cancer is a gain-of-function mutation that promoted TNF signaling activation compared with wild-type EPHB2. We provide evidence that the EPHB2-RNF186-TAB2-TAK1 signaling cascade plays an essential role in TNF-mediated signal transduction in colorectal epithelial cells and the carcinogenesis of colorectal cancer, which may provide potential targets for the treatment of colorectal cancer.
Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection
Authors: Das Antu , Wang Xingan , Wei Jianxin , Hoji Aki , Coon Tiffany A , Popescu Iulia , Brown Mark , Frizzell Sheila , Iasella Carlo J , Noda Kentaro , Sembrat John C , Devonshire Kaitlyn , Hannan Stefanie J , Snyder Mark E , Pilewski Joseph M , Sanchez Pablo G , Chandra Divay , Mallampalli Rama K , Alder Jonathan K , Chen Bill B , McDyer John F
Published: October 2022

Chronic lung allograft dysfunction is the major barrier to long-term survival in lung transplant recipients. Evidence supports type 1 alloimmunity as the predominant response in acute/chronic lung rejection, but the immunoregulatory mechanisms remain incompletely understood. We studied the combinatorial F-box E3 ligase system: F-box protein 3 (FBXO3; proinflammatory) and F-box and leucine-rich repeat protein 2 (FBXL2; anti-inflammatory and regulates TNFR-associated factor [TRAF] protein). Using the mouse orthotopic lung transplant model, we evaluated allografts from BALB/c → C57BL/6 (acute rejection; day 10) and found significant induction of FBXO3 and diminished FBXL2 protein along with elevated T-bet, IFN-γ, and TRAF proteins 1–5 compared with isografts. In the acute model, treatment with costimulation blockade (MR1/CTLA4-Ig) resulted in attenuated FBXO3, preserved FBXL2, and substantially reduced T-bet, IFN-γ, and TRAFs 1–5, consistent with a key role for type 1 alloimmunity. Immunohistochemistry revealed significant changes in the FBXO3/FBXL2 balance in airway epithelia and infiltrating mononuclear cells during rejection compared with isografts or costimulation blockade–treated allografts. In the chronic lung rejection model, DBA/2J/C57BL/6F1 > DBA/2J (day 28), we observed persistently elevated FBXO3/FBXL2 balance and T-bet/IFN-γ protein and similar findings from lung transplant recipient lungs with chronic lung allograft dysfunction versus controls. We hypothesized that FBXL2 regulated T-bet and found FBXL2 was sufficient to polyubiquitinate T-bet and coimmunoprecipitated with T-bet on pulldown experiments and vice versa in Jurkat cells. Transfection with FBXL2 diminished T-bet protein in a dose-dependent manner in mouse lung epithelial cells. In testing type 1 cytokines, TNF-α was found to negatively regulate FBXL2 protein and mRNA levels. Together, our findings show the combinatorial E3 ligase FBXO3/FBXL2 system plays a role in the regulation of T-bet through FBXL2, with negative cross-regulation of TNF-α on FBXL2 during lung allograft rejection.
Sharks Provide Evidence for a Highly Complex TNFSF Repertoire in the Jawed Vertebrate Ancestor
Authors: Redmond Anthony K , Pettinello Rita , Bakke Fiona K , Dooley Helen
Published: October 2022

Cytokines of the TNF superfamily (TNFSF) control many immunological processes and are implicated in the etiology of many immune disorders and diseases. Despite their obvious biological importance, the TNFSF repertoires of many species remain poorly characterized. In this study, we perform detailed bioinformatic, phylogenetic, and syntenic analyses of five cartilaginous fish genomes to identify their TNFSF repertoires. Strikingly, we find that shark genomes harbor ∼30 TNFSF genes, more than any other vertebrate examined to date and substantially more than humans. This is due to better retention of the ancestral jawed vertebrate TNFSF repertoire than any other jawed vertebrate lineage, combined with lineage-specific gene family expansions. All human TNFSFs appear in shark genomes, except for lymphotoxin-α (LTA; TNFSF1) and TNF (TNFSF2), and CD70 (TNFSF7) and 4-1BBL (TNFSF9), which diverged by tandem duplications early in tetrapod and mammalian evolution, respectively. Although lacking one-to-one LTA and TNF orthologs, sharks have evolved lineage-specific clusters of LTA/TNF co-orthologs. Other key findings include the presence of two BAFF (TNFSF13B) genes along with orthologs of APRIL (TNFSF13) and BALM (TNFSF13C) in sharks, and that all cartilaginous fish genomes harbor an ∼400-million-year-old cluster of multiple FASLG (TNFSF6) orthologs. Finally, sharks have retained seven ancestral jawed vertebrate TNFSF genes lost in humans. Taken together, our data indicate that the jawed vertebrate ancestor possessed a much larger and diverse TNFSF repertoire than previously hypothesized and oppose the idea that the cartilaginous fish immune system is “primitive” compared with that of mammals.
A finTRIM Family Protein Acquires RNA-Binding Activity and E3 Ligase Activity to Shape the IFN Response in Fish
Authors: Qu Zi-Ling , Li Yi-Lin , Gong Xiu-Ying , Zhao Xiang , Sun Hao-Yu , Dan Cheng , Gui Jian-Fang , Zhang Yi-Bing
Published: October 2022

Tripartite motif (TRIM) family proteins have come forth as important modulators of innate signaling dependent on of E3 ligase activity. Recently, several human TRIM proteins have been identified as unorthodox RNA-binding proteins by RNA interactome analyses; however, their targets and functions remain largely unknown. FTRCA1 is a crucian carp (Carassius auratus)–specific finTRIM (fish novel TRIM) member and negatively regulates the IFN antiviral response by targeting two retinoic acid–inducible gene-I (RIG-I)–like receptor (RLR) pathway molecules, that is, TANK-binding kinase 1 (TBK1) and IFN regulatory factor 7 (IRF7). In this study, we identify FTRCA1 as an RNA-binding E3 ligase and characterize the contribution of its RNA-binding activity and E3 ligase activity to fish IFN response. Besides targeting TBK1 and IRF7, FTRCA1 downregulates fish IFN response also by targeting stimulator of IFN response cGAMP interactor 1 (STING1). E3 ligase activity is required for full inhibition on the TBK1- and IRF7-mediated IFN response, but partial inhibition on the STING1-mediated IFN response. However, FTRCA1 has a general binding potential to mRNAs in vitro, it selectively binds STING1 and IRF7 mRNAs in vivo to attenuate mRNA levels, and it directly interacts with TBK1 protein to target protein degradation for downregulating the IFN response. Our results present an interesting example of a fish species–specific finTRIM protein that has acquired RNA-binding activity and E3 ligase activity to fine-tune fish IFN response.
Peribronchial Inflammation Resulting from Regulatory T Cell Deficiency Damages the Respiratory Epithelium and Disturbs Barrier Function
Authors: Jonckheere Anne-Charlotte , Steelant Brecht , Seys Sven F , Cremer Jonathan , Dilissen Ellen , Boon Louis , Liston Adrian , Schrijvers Rik , Breynaert Christine , Vanoirbeek Jeroen A J , Ceuppens Jan L , Bullens Dominique M A
Published: October 2022

Regulatory T cells (Tregs) that express the transcription factor Foxp3 have a critical role in limiting inflammatory processes and tissue damage. Whether Tregs are functional in maintaining epithelial barriers and in control of tight junction expression has not yet been explored. In this study, we investigated the effect of Treg deficiency on the airway epithelial barrier in an experimental murine model in which diphtheria toxin was repeatedly injected in Foxp3-diphtheria toxin receptor (DTR) mice to deplete Tregs. This resulted in spontaneous peribronchial inflammation and led to a systemic and local increase of IL-4, IL-5, CCL3, IFN-γ, and IL-10 and a local (lung) increase of IL-6 and IL-33 and decreased amphiregulin levels. Moreover, Treg depletion increased airway permeability and decreased epithelial tight junction (protein and mRNA) expression. CTLA4-Ig treatment of Treg-depleted mice almost completely prevented barrier dysfunction together with suppression of lung inflammation and cytokine secretion. Treatment with anti–IL-4 partly reversed the effects of Treg depletion on tight junction expression, whereas neutralization of IL-6 of IFN-γ had either no effect or only a limited effect. We conclude that Tregs are essential to protect the epithelial barrier at the level of tight junctions by restricting spontaneous T cell activation and uncontrolled secretion of cytokines, in particular IL-4, in the bronchi.
Antibiotic use in endodontic treatment during pregnancy: A narrative review
Authors: Aliabadi Tahere , Saberi Eshagh Ali , Motameni Tabatabaei Amin , Tahmasebi Ebadolah
Published: October 2022

More than half of pregnant women are usually affected by odontogenic pain affects. Pain often accompanies periapical or pulp infections and increases the risks to pregnant patients and their fetuses. The American Dental Association, in partnership with the American College of Obstetricians and Gynecologists, has offered a strong declaration reaffirming the significance of suitable and timely oral health care as an indispensable constituent of a healthy pregnancy. However, there is lack of knowledge about the use of antibiotics in endodontic treatment. Therefore, the present study would review the researches done in this area and tries to provide comprehensive and complete information about the use of antibiotics in endodontic treatment during pregnancy. Based on the results, it can be said that using antibiotics during pregnancy are allowed, and they can be used normally and safely by pregnant women.
Asymptotic formula for the multiplicative function $\frac{d(n)}{k^{\omega(n)}}$
Authors: Karras Meselem
Published: October 2022

For a fixed integer $k$, we define the multiplicative function
\[D_{k,\omega}(n) := \frac{d(n)}{k^{\omega(n)}}, \]where $d(n)$ is the divisor
function and $\omega (n)$ is the number of distinct prime divisors of $n$. The
main purpose of this paper is the study of the mean value of the function
$D_{k,\omega}(n)$ by using elementary methods.
EL TURISMO CULTURAL EN LA GUAJIRA Y LOS PUEBLOS ORIGINARIOS, UNA POSIBILIDAD DE DESARROLLO PARA LOS TIEMPOS DE LA POSTPANDEMIA
Authors: Pérez Mendoza Katherin , Busón Carlos , Carabalí Angola Alexis
Published: October 2022

Este trabalho faz parte de uma investigação do Mestrado em Ciências Sociais da Universidade de La Guajira para analisar o valor que as comunidades indígenas assentadas na costa de Mayapo dão à cultura, turismo e solidariedade em seus territórios marinho-costeiros. Entre os objetivos que pretendíamos estudar estava identificar a valoração econômica e social dos ecossistemas costeiros a partir da visão de mundo Wayuu. Este trabalho justifica-se como parte de uma investigação em busca de valoração econômica da incidência de riscos socioambientais nos sistemas produtivos locais. Este estudo teve como objetivo avaliar os ecossistemas costeiros de Mayapo localizados no município de Manaure, por meio de um desenho metodológico que respondeu a uma definição dos territórios de acordo com as práticas, usos e costumes presentes nas tradições da comunidade indígena Wayuu. Da mesma forma, poderia servir de insumo para a criação de estratégias de desenvolvimento, planos de uso da terra e o desenho de instrumentos metodológicos para o uso responsável dos serviços ecossistêmicos prestados por áreas de alto valor cultural.
Religion and Pandemic: Shifts of Interpretation, Popular Lore, and Practices. An Introduction
Authors: Agadjanian Alexander , Siekierski Konrad
Published: October 2022

In this Introduction, the guest editors discuss the main themes of this special issue and relate them to the growing field of research on how the extraordinary social conditions of the Covid-19 pandemic affected the practices of religious individuals, groups, and institutions. As we suggest here, the pandemic revealed and catalysed important trends within religious traditions and also exacerbated the issues of specific religious identities as confronted against, or negotiated with, the dominant frame of secular state-controlled public health priorities, policies, and protocols.
A Critical Review on Sustainable Development of Green Smart Cities (GSCs) for Urbanization
Authors: Pradhan Devasis , Ray Samrat , Dash A.
Published: October 2022

This paper expects to dissect logical investigations zeroing in on both ecological maintainability and shrewd city ideas to discover the connection between these two. To do so, the review distinguishes data about scientists, models, structures, and devices zeroed in on the picked subjects. This examination utilizes a subjective strategy, through a precise survey of the writing, which looks at the terms, 'smart city and its sustainability', focused on maintainable improvement of smart urban communities. As per the 2030 Plan is a reasonable improvement achievement for humankind in its desire to focus on our people in the future really. Smart Urban areas assume a fundamental part in this turn of events, the turn of events heading is based, among different elements, on the satisfaction of the models set by the different Sustainable Development Objectives (SDOs). The motivation behind the ebb and flow research is to check the present status of science concerning the improvement of the SDOs in smart cities to lay out a hypothetical structure for the turn of events and mix of information well defined for a Smart City to partake in homogeneous observing of these pointers.
Hidden Identity: A Constructivist Grounded Theory of Black Male Identity Development at Historically Black Colleges and Universities
Authors: Rogers Therron , Mitchell, Jr. Donald
Published: October 2022

Identity development models for Black males are limited, particularly within the context of higher education. Within this qualitative study, we used constructivist grounded theory to develop a theory of Black male identity development at historically Black colleges and universities (HBCUs). We were guided by the following research questions: (1) How do the experiences at a historically Black college or university influence the identity development for Black males? (2) What externalfactors influence identity development for Black males who attend a historically Black college or university? Eight Black males participated in this study, each completing series of semistructured interviews. Derived from the interviews, a four-phase identity development theory emerged. The four phases of Black male identity development at HBCUs are: (1) acknowledgment of Black male identity, (2) understanding of differences among Black males, (3) creation of professional identity, and (4) transition into Black male role model. Our theory highlights how HBCUs offer unique spaces for Black male identity development that continues through adulthood. We close with recommendations for practice and future research.
A Review of Decolonial Feminist Research: Haunting, Rememory and Mothers (Futures of Data Analytics in Qualitative Research)
Authors: Romero, Jr. Jerry
Published: October 2022

How do we begin to connect to those who are no longer living, those who have been historically silenced, and those whose memory becomes a faint existence in our modern, colonial imaginary? Within Decolonial Feminist Research: Haunting, Rememory, and Mothers, Jeong-eun Rhee, a qualitative educational researcher, examines the tension that often accompanies the implementation of decolonial feminist knowledges, methodologies, and epistemologies, especially when these theoretical perspectives challenge the academic canon rooted in modernity and social scientific empirical realities. This review addresses Rhee’s major theoretical conceptualizations such as Rememory, M/others and Haunting throughout the various processes that often connect individuals through death and grieving. Rhee demonstrates that the production of knowledge being constructed through the rememory of those who have since passed, not only provides existence to their stories, but makes their lives, histories, and memories “very much alive and present.” Rhee challenges notions of the living/dead, remembrance/forgotten, time, national borders, and the fragmented self in an effort to establish new decolonial imaginaries and methodologies for bringing the silenced voices of women of color to the forefront of our modern reality. This book is recommended for any qualitative researchers and decolonial feminist scholars who are interested in challenging colonial matrices of power that often silence voices/stories from being included in western canons of academia, and those who want to examine the very notions of academic scholarship, epistemology, ontology, and methodology in order to secure a place where the rememory of those silenced out of existence can thrive and whose haunting enacts a decolonial resistance to the continued systems of oppression dominating the colonized other.
Pengaruh Perawatan Metode Kangguru terhadap Stress Hemodinamik pada Bayi Berat Lahir Rendah di RS Annisa Tangerang 2020
Authors: Nurpaijah Nurpaijah , Setia Sari Ria
Published: October 2022

Kondisi di Neonatologi berupa kebisingan, pencahayaan, bau-bauan, penggunaan alat dan prosedur yang dapat menimbulkan stress dan nyeri sangat berkontribusi terhadap morbiditas. Bayi baru lahir sering terpapar dengan sejumlah prosedur yang menyebabkan nyeri baik prosedur diagnostic, prosedur terapeutik, maupun pemasangan alat untuk monitoring parameter fisiologis. Semua tindakan ini bisa menimbulkan stress pada bayi. Dampak jika bayi stress adalah perubahan pada fungsi fisiologis bayi, seperti hipotermi, peningkatan denyut jantung bayi, frekuensi nafas akan menyebabkan apneu berulang, presentasi Hemoglobin yang di ikat oleh oksigen (SPO2) cenderung menurun. Tujuan penelitian ini adalah untuk mengetahui pengaruh perawatan metode kangguru terhadap stress hemodinamik pada bayi berat lahir rendah di Rumah Sakit Annisa tangerang 2020. Metode penelitian yang digunakan dalam penelitian ini adalah quasi eksperimental design: one group pre test and post test design. Populasi dalam penelitian ini berjumlah 35 responden. Tehnik yang digunakan untuk pengambilan data adalah accidental sampling. Hasil penelitian: Berdasarkan uji statistik bahwa p-value < 0,05 maka dapat dinyatakan HO ditolak artinya ada pengaruh antara Perawatan Metode Kangguru Terhadap Stress Hemodinamik Pada Bayi Berat Lahir Rendah Di RS Annisa Tangerang 2020. ada pengaruh antara Perawatan Metode Kangguru Terhadap Stress Hemodinamik Pada Bayi Berat Lahir Rendah Di Rs Annisa Tangerang 2020.
Trends in Production and Export Potential of Ginger in India
Authors: Mula Gobinda
Published: October 2022

Large cardamom is an important cash crop for the farmers of Sikkim. This paper estimated the trend, growth, and instability in large cardamom production in Sikkim. The paper also forecasts the area, production,and yields of the crop for the period 2003-2019. The study revealed that there is a positive significant linear trend in the production and yield of large cardamom. The annual growth was also positive for production and yield of large cardamom. The study forecasted that the area under cardamom is to decline by 2030 while the production and yield of the crop was estimated to increase in future. Correlation and regression technique was used to study the effect of climate change on the production of large cardamom during the same period. The study showed that annual rainfall had positive and significant influence on production of the crop. Hence, assured irrigation during the critical phase of crop growth will ensure steady production of the crop.
Classics for the third millennium: African options after the Fall
Authors: Claassen Jo-Marie
Published: October 2022

It is impossible to speak for a whole continent; hence, in spite of the, this chapterconcentrates on the situation in South Africa and its more immediate neighbour, Zimbabwe. Much of what follows is derived from the author's work of 22 years ago; obsolete statements have been excised, or cited as no longer apposite; others are updated critically, with an indication of what changed and, in some cases, a prediction of what may still lie ahead.
Diabetes en cardiovasculaire risicobepalingen in Belgische officina-apotheken
Authors: Vandersteen L. , Tommelein E.
Published: October 2022

Diabetes and cardiovascular risk assessments in Belgian community pharmacies

Type 2 diabetes mellitus (T2DM) and cardiovascular disease are major health problems related to a number of modifiable risk factors such as obesity, an unhealthy lifestyle, hypertension and hypercholesterolemia. Early detection and management of these risk factors are essential to avoid severe long-term complications. Until now, screening for risk factors for T2DM and cardiovascular diseases in Belgium has been largely the task of the general practitioner. However, various international studies show that the community pharmacist can play a complementary role in this.

This article provides an overview of the Belgian projects with T2DM and cardiovascular risk assessment in pharmacies. Between 2014 and 2021, there were 5 projects with T2DM and cardiovascular risk assessment in the community pharmacy in Belgium. These projects show that community pharmacists have screening tools at their disposal to perform an adequate risk assessment. Relative to the total number of patients screened, the percentage of patients referred by the pharmacist because of a high risk for T2DM varied between 25% and 58%. In 1 project with an additional cardiovascular risk assessment, 63% was referred because of an increased risk for cardiovascular disease.

These results highlight the potential for the pharmacist’s role in the prevention of DM and cardiovascular diseases. Due to their proximity and accessibility, pharmacists can play an important complementary social role in the early recognition of chronic diseases in people who do not or irregularly use medical care.
Pengembangan Sistem Monitoring Jaringan KomputerMenggunakan Dude
Authors: Tenriawaru Andi , Subardin Subardin , Nurkaeani Nurkaeani
Published: October 2022

Perkembangan teknologi informasi pada saat sekarang ini para administrator jaringan dituntut untuk bekerja dengan cepat, handal dan professional ketika terjadi masalah pada lalu lintas (traffic) infrastruktur jaringan yang ditanganinya. Sementara itu disisi lain para administrator jaringan tidak selamanya berada di kantor untuk memonitoring unjuk kerja dan lalu lintas infrastruktur jaringan. Masalah yang terjadi pada operasional jaringan akan mengakibatkan kerugian yang tidak kecil, terutama pada instansi-instansi yang memanfaatkan teknologi jaringan. Berdasarkan referensi monitoring jaringan menggunakan aplikasi whireshark digunakan memantau atau melihat pada kualitas  jaringan. Oleh karena itu,  Hal tersebut membuat peneliti tertarik mengambil judul “Pengembangan Sistem Monitoring Jaringan Komputer   Menggunakan Dude”. Pada penelitian ini sistem monitoring agar bekerja atau berfungsi untuk mendeteksi pada jaringan. Sebuah sistem monitoring melakukan proses pengumpulan data mengenai dirinya sendiri dan melakukan analisis terhadap data-data yang dimiliki data yang dikumpulkan pada umumnya merupakan data yang  real-time, baik data yang diperoleh dari sistem yang hard real-time maupun sistem yang  soft real-time. Observasi awal penelitian sampai pada tahap proses pengujian dapat disimpulkan. Kecepatan troughput yaitu 62 bits/s dan packet loss yaitu   Dengan hasil pengukuran troughput dan packet loss sesuai dengan kategori tiphon termasuk kategori bagus. Dengan adanya pengembangan monitoring jaringan menggunakan aplikasi the dude memperkecil kemungkinan kesalahan dan mempermudah kepada putugas/operator di saat ada koneksi internet komputer yang down/terputus.
UMA BREVE HISTÓRIA DA ASTROFÍSICA
Authors: Paulo de Melo Martins João , Aparecido Pinto Osório Francisco , Gonçalves Rodrigues Clóves
Published: October 2022

Neste artigo se relatou, de maneira muito breve, a história da astrofísica de forma didática e acessível. O foco do trabalho é na parte histórica, sem entrar em detalhes matemáticos, passando pelos principais acontecimentos desta ciência nos últimos séculos, detalhando sobre alguns dos principais cientistas que fizeram contribuições nesta área. Neste artigo se procurou apresentar o desenvolvimento histórico da mecânica celeste dos corpos, da espectroscopia, algumas ferramentas utilizadas na catalogação das estrelas, a composição química dos corpos celestes, e o papel da teoria e da experimentação física nesta área. É realizada, também, uma breve apresentação da evolução dos aparatos de observação espacial como telescópios e radiotelescópios. Questionamentos sobre o que está por vir em um futuro próximo (ou não) também são discutidos.
Fibre-Reinforced Soil Mixed Lime/Cement Additives: A Review
Authors: Tamassoki Sakina , Nik Daud Nik Norsyahariati , Nejabi Mohammad Nazir , Roshan Mohammad Jawed
Published: October 2022

Soil modification is a technique for improving poor soil properties to make them suitable for engineering projects. Regarding the previous studies, various types of stabilisations were used to improve mechanical properties in soil. Several methodologies and experimental tests were used to study the positive and negative effects of utilising fibre on lime/cement-modified soil. This paper reviews the strength behaviour and microstructural properties of Fibre-Reinforced Lime Stabilised (FRLS) soil and Fibre-Reinforced Cement Stabilised (FRCS) Soil. First, the impact of FRLS/FRCS soil on strength behaviour under freeze-thaw conditions, the California Bearing Ratio (CBR) value, and compression/tensile strength are all examined. Then synthetic and natural fibres are compared at the microstructure level. FRCS/FRLS soil has been studied for its influence on geotechnical characteristics such as peak strength, residual strength, ductility, bearing capacity, stiffness, and settlement values. In addition, the micro-level evidence demonstrates that lime/cement affects the interlocking between soil particles and fibre. Although lime/cement improves soil strength by making it solid and compact, it makes stabilised soil brittle. Fibre as reinforcement in lime/cement stabilised soil transforms the brittleness of the soil into ductility. Hence building various infrastructures on poor soils is possible if fibre with lime/cement is used as an improvement method. Here, these three most used soil additive materials are investigated in terms of strength, microstructural, mineralisation, and some open issues are suggested for further research.
Redesigning the College of Education Curriculum to meet the Learner Centered Approach Needs of the Pre-service teacher for Effective Implementation of the Standard Based Curriculum in Ghana
Authors: Yekple Sampson, L.K , Kumi John-Newton , Kumah Maxwell, S.
Published: October 2022

Purpose: There is the need for the training of Pre-Service Teachers (PST) to appreciate and exhibit Learner Centered Approach (LCA) in the teaching and learning process. As we celebrate the preparedness of the college of education tutors to impart this knowledge to the PST, the space to deliver is faced with challenges. This paper aims at exploring how tutors are implementing the practices in LCA in colleges of education in their lesson delivery. It also aims at populating the challenges associated with the implementing the approach. The paper in addition, aims at highlighting the possible practices that can support Pre-Service Teachers to appreciate the use LCA in facilitating concepts in the classroom.

Methodology: This current qualitative research adopted exploratory and descriptive design. Qualitative data was collected through interview. Three Colleges of Education (CoE) in VOLTI zone were purposively sampled for the study.

Result: From the interview results, it was found that, college curriculum on academic content is focusing much of its attention on academic content than practicum. The mode of assessment is also making the impartation of LCA to the pre-service teacher seemingly untenable. The college tutors are functionally equipped to impart the methodology of LCA to the pre-service teacher, however the use of the LCA does not support them co cover much curriculum content.  Tutors struggle to complete the semester’s curriculum hence a deviation from the low usage of the LCA. It is also noted that, quizzes and End of Semester examination assessment items do not reflect practicum. The observation results supportively confirm that tutors have difficulty of integrating LCA in the teaching of content related courses due to their apparent focus on examination.

Unique Contribution to Theory, Policy and Practice: It is therefore concluded that, the current practice of promoting LCA without appropriate forms of assessment to sustain its practice demotivates both tutors and students to engage in such classroom practices. We therefore recommend that, the B.Ed program is reorganized to include more practicum to prepare functional PST in towards the facilitation of the Standard based Curriculum.
Claude Debussy’nin “Première Rhapsodie” İsimli Eserine Klarnet İcracıları Perspektifinden Bir Bakış
Authors: UYAR Orkun , YAVUZ Deniz
Published: October 2022

“İzlenimcilik” akımının ve 20. yüzyıl müziğinin en önemli bestecilerinden olan Claude Debussy’nin Première Rhapsodie isimli eserinin, klarnet icracılarının perspektifinden değerlendirildiği bu çalışmada, bestecinin müzik dilinin, hedeflediği anlatım tarzının ele alınmasının yanı sıra hem klarnet hem de oda müziği repertuarında önemli bir yeri olan bu eserin yorumlanmasında kolaylık sağlayıcı bir kaynak oluşturularak çalıcılara katkı sağlanması amaçlanmıştır.

20. yüzyıl klarnet repertuarının en önemli eserleri arasında yer alan Claude Debussy’nin Première Rhapsodie isimli eseri, uluslararası yarışmalarda belirleyicilik özelliği yüksek bir eser olduğu gibi, resital programlarında da sıkça yerini almaktadır. Bu çalışmada öncelikle bestecinin yaşamı, eserleri, müzikal kimliği incelenmiş, ardından eserin müzikal analizine de kısaca değinilmiştir. Bu bilgiler ışığında bu çalışmanın, klarnet icracıları ve piyanistler için önem arz eden bu eser hakkında farklı bir bakış açısı kazandıracağı düşünülmektedir.
Assessment of Total Cardiovascular Risk Using WHO/ISH Risk Prediction Chart Among Adults in Oman: A Nationally Representative Survey
Authors: Al-Mawali Adhra , Al-Harrasi Ayaman , Pinto Avinash Daniel , Jayapal Sathish Kumar , Morsi Magdi , Al-Shekaili Waleed , Al-Kharusi Hilal , Idikula John
Published: October 2022

Objectives: Cardiovascular diseases (CVDs) are the major cause of morbidity and mortality globally and in Oman. Stratifying the population under different risk levels based on the total CVD risk approach using the World Health Organization/International Society of Hypertension (WHO/ISH) risk prediction chart would be more effective in primary prevention of CVD to prioritize and utilize valuable resources. Hence, this study aimed to assess the total 10-year CVD risk among adults in Oman and to ascertain the proportion of the population in need of pharmacotherapy. Methods: We used the data from the 2017 national community-based STEPS survey conducted among men and women in Oman aged 40–80 years. Ten-year total cardiovascular risk was measured using the WHO/ISH risk prediction chart for Eastern Mediterranean Sub-Region B. Independent t-test and Chi-square were used to test significance. Results: There were 2510 participants in the study. Their mean age was 51.5±10.1 years and 51.3% were male. The prevalence of low, moderate, and high CVD risk was 68.0%, 19.1%, and 12.9%, respectively, as benchmarked by the WHO/ISH chart. Immediate pharmacotherapy was needed by 30.3% of participants. Factors significantly associated with elevated CVD risk were the participant's age (p <0.001), education level (p< 0.001), and employment status (p< 0.001). Conclusions: A substantial fraction of the population in Oman are at moderate or high CVD risk. Prompt pharmacological interventions are warranted for at least one in every five individuals in conjunction with lifestyle changes.
In the Kitchen, 1550-1800
Authors: Bassnett Madeline , Nunn Hillary , Crow Andy , Fisher Julie A. , Goldstein David B. , Laroche Rebecca , Munroe Jennifer , Schultheis Melissa , Simon Margaret , Snook Edith , Tigner Amy L. , Wakeman Rob , Walker Katherine
Published: October 2022

In the Kitchen insists that the preparation of food, whether imaginative, physical, or spatial, is central to a deeper understanding of early modern food cultures and practices. Devoted to the arts of cooking and medicine, early modern kitchens concentrated on producing, processing, and preserving materials necessary for nourishment and survival; yet they also fed social and economic networks and nurtured a sense of physical, spiritual, and political connection to surrounding lands and their cultures. The essays in this volume illuminate this expansive view of cooking and aspire to show how the kitchen's inner workings prove tightly, though often invisibly, interwoven with local, national, and, increasingly, global surroundings. Engaging with literary and historical methodologies, including close reading, recipe analysis, and perspectives on gender, class, race, and colonialism, we begin to develop a shared theoretical and practical language for the art of cooking that combines the physical with the intellectual, the local with the global, and the domestic with the political.
Sympoeisis and Early Modern Cooking: Troubling the Boundaries of Human/Nonhuman
Authors: Munroe Jennifer
Published: October 2022

As a site of food and medicine preparation, the early modern kitchen
served as an interface between human and nonhuman, the house and
its environs. This chapter considers how cooking illustrates what Donna
Haraway calls ‘sympoeisis’ or ‘collectively producing systems that do not
have self-defined spatial or temporal boundaries.’ I argue that work in
and out of (and across) the early modern kitchen provides a useful way
to rethink what it means to be human and nonhuman, how cooking is
an endeavour that particularly blurs the lines between them. Cooking,
that is, is an inherently ‘tentacular’ practice (drawing again on Haraway),
one that highlights webbed relations between co-agentic things (human
and nonhuman alike).
The Power of the Pot: Naturalizing Carp Through the Early Modern English Receipt Book
Authors: Wakeman Rob
Published: October 2022

How did early modern cooks and their recipe books respond to the
introduction of invasive species? The introduction of the common carp
to England provides an illuminating example. At the end of the fifteenth
century, manors and monasteries began to stock ponds in England with
imported carp, but they quickly colonized English river systems. Their
tolerance for mucky waters helped them thrive in England, but less-thanpristine
environments affected the taste of their flesh and resulted in
divided culinary opinion. This essay examines strategies for dressing
carp that proliferated through the seventeenth century as cooks sought
to transform this stranger fish into a naturalized British dish.
How to Make a Bisk: The Restoration Cookbook as National Restorative
Authors: Goldstein David B.
Published: October 2022

Scholars credit Robert May and William Rabisha with a central role in the
development of seventeenth-century English courtly cuisine. Focusing
on a recipe common to both of them—the ‘bisque’ or ‘bisk’—I argue
that in the hands of these authors, this ‘grand boyled meat’ ushered in
a new approach to English cuisine. Working within the framework of
Restoration hospitality, Rabisha and May attempt to transform society by
harmonizing foreign influences in order to expand the culinary, religious,
and political boundaries of Englishness. The bisk symbolizes a table at
which all England shares in a national commensality, even as aspects of
that commensality remain fiercely debated.
‘A Little Winter Savory, A Little Time’: Making History in Elizabeth Cromwell’s Kitchen
Authors: Crow Andy
Published: October 2022

This article examines a puzzling question surrounding the 1664 recipe book,
The Court & Kitchin of Elizabeth, an anonymous collection purporting to
explain the Cromwells’ unfitness to govern by examining their favorite
recipes. Scholars have viewed the text as satirizing Elizabeth as stingy in
household management and low-class in taste. Yet why would an author
opposed to the Cromwells offer the reader a work that invited them to recreate
the Cromwellian dining experience for themselves? I argue that the collection
draws on the early modern association of the kitchen with the manipulation of
time, guiding readers to learn through creating its recipes how to avoid future
temporal ruptures of the sort that its author viewed the Protectorate to be.
Writing about German Literature
Authors: Reh Sabine
Published: October 2022

This chapter shows what new insights into mother-tongue teaching and
its history can be gained by looking at the practice of testing. A particular
historical case is used, namely, the introduction of the Zentralabitur after
World War II by the French occupation forces in southwestern Germany.
The chapter outlines how the French implemented a form of directly
competitive examination anchored in their country and how teachers
of German literature classes reacted to the new examination system.
Using student essays written as part of a competition and judged by
teachers, the author traces how German literary culture and ideas about
individual-authentic writing on literature come to the fore anew despite
the adoption of testing practices from France.
IMPLEMENTASI PERATURAN BUPATI BIREUEN NOMOR 74 TAHUN 2019
Authors: Qadafi Muammar
Published: October 2022

Penelitian ini mengkaji tentang penggabungan Satuan Polisi Pamong Praja dan Wilayatul Hisbah. Tujuan penelitian ini untuk memahami tingkat keefektifan Implementasi Peraturan Bupati Bireuen No. 74 Tahun 2019 tentang Satuan Polisi Pamong Praja dan Wilayatul Hisbah dan untuk mengetahui apa saja hambatan/kendala dalam penerapan Peraturan Bupati Bireuen tersebut. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif analisis, karena persoalannya sangat komprehensif, mendalam dan luas. Perspektif teoritik dalam penelitian ini adalah teori kebijakan publik. Pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa implementasi Peraturan Bupati Bireuen No. 74 Tahun 2019 di Kabupaten Bireuen belum berjalan dengan lancar, rekrutmen belum sesuai prosedur, sumber daya yang masih belum kompeten, serta dukungan masyarakat terhadap implementasi peraturan bupati masih kurang. Tujuan terbuntuknya Wilayatul Hisbah sebagai pengawasan dan penegakan perda syariat Islam. Bergabungnya Wilayatul Hisbah berada di bawah Satuan Polisi Pamong Praja membuat kewenangan Wilayatul Hisbah tidak lagi berpengaruh besar dan eksistensi Wilayatul Hisbah sudah berkurang.
Testing the Impact Chain Model: Exploring Social Vulnerability to Multiple Hazards and Cascading Effects
Authors:   Stockholm Environment Institute, André Karin , Englund Mathilda , Gerger Swartling Åsa
Published: October 2022

This fact sheet presents an overview of how the impact chain method can be used to explore social vulnerability to multiple hydrometeorological hazards and their cascading effects, in a case study in Halmstad Municipality, Sweden. A particular focus in this case study was the methodological research and innovation (R&I) area of co-production of knowledge, with lessons learned presented here.