bluuebunny/crossref_metadata_2025 huggingface dataset:
Inferring Lead Risk from Drinking Water Compliance Data
Authors: CARDEW PETER , Gregory Keith , Lechmere Adam
Published: November 2023

In order to meet the EU requirement of compliance with the 10 µg/l lead standard utility companies in England and Wales implemented a large-scale plumbosolvency treatment programme based around the addition of orthophosphate. This was largely delivered by the end of 2003. This solution has resulted in a major improvement in compliance (circa 99%) as measured through random daytime sampling. A consequence of this substantial improvement is a desire to re-optimise treatment for efficiency, minimise potential environmental impacts and maximize benefits from targeted lead pipe replacement programmes. The extent to which compliance data can be used to provide evidence-based justification for these objectives is examined for supplies in the north-west of England. In the twelve years since the treatment solution was implemented lead non-compliance has steadily fallen from 3.0 % in 2004 to less than 0.3 % over in 2016, despite minimal changes in treatment, indicating that long term structural changes in the corrosion layer are occurring over this timescale. Only by combining regulatory and operational data collected over 5-year period to form a large data set (N=62,810) did significant non-random deviations emerge. The resulting zonal compliance distribution was characterised as a zero-inflated overdispersed Poisson. A large part of the overdispersion was accounted for by the zonal variation in the proportion of properties with lead service pipes. This variation also accounted for the zero-inflated aspect which relates to a substantial number of zones having few or no lead service pipes. Such areas may provide economic opportunity for small lead pipe replacement programmes as an alternative to plumbosolvency treatment. At a regional level compliance varies with property age peaking in the period 1919 and 1940. This is accounted for by the historical selection of lead has the preferred material for service pipes. The analysis shows that in order to assess zonal lead risk from random daytime data it is essential to have quantitative information about the proportion of properties with lead service pipes. Incidentally, it was found that the risk of non-compliance in properties with lead service pipes was nearly thirty times that in properties without lead service pipes. Analysis of compliance data by supply provided only limited justification for re-optimisation of treatment. This issue will get more difficult with further improvement in compliance.
Structure-based design of a potent and selective YTHDC1 ligand
Authors: Zálešák František , Nai Francesco , K. Bedi Rajiv , Li Yaozong , Herok Marcin , Bochenkova Elena , Errani Francesco , Caflisch Amedeo
Published: November 2023

N6-Adenosine methylation (m6A) is a prevalent post-transcriptional modification of mRNA, with YTHDC1 being the reader protein responsible for recognizing this modification in the nucleus of the cell. Here we present a protein structure-based medicinal chemistry campaign that resulted in the YTHDC1 inhibitor 40 which shows an equilibrium dissociation constant (Kd) of 49 nM. The crystal structure of the complex (1.6-Å resolution) validated the design. Compound 40 is selective against the cytoplasmic m6A-RNA readers YTHDF1-3 and YTHDC2 and shows antiproliferative activity against the acute myeloid leukemia (AML) cell lines THP-1, MOLM-13, and NOMO1. For the series of compounds that culminated into ligand 40, the good correlation between the affinity in the biochemical assay and antiproliferative activity in the cellular assay (THP-1) provides evidence of YTHDC1 target engagement in the cell. Thus compound 40 meets chemical probe properties for studying the role of YTHDC1 in AML.
Analysis of derivational process from the perspective of the morpheme-based morphology theory in kurdish and persian
Authors: Hamad Darya , Hamad Sherwan , Karimi Yadgar
Published: November 2023

The main purpose of this study is to present the derivational process in the analysis of Kurdish and Persian words from the perspective of the morpheme-based morphological theory of how morphemes are arranged together to form words. Then, the similarities and differences between the two languages within the framework of the derivational process are presented. In this theory, the main unit of morphological analysis is a morpheme, which is a unit comprised of a word or something smaller than a word, whether it is a free morpheme or an affix. Similarly, affixes, like lexical free morphemes, have their lexical entry in the dictionary of every language. Therefore, we have employed the Lieber model of lexical organization, which is a morpheme-based morphology theory. . After that, we have taken some derivational words that are analyzed via this theory within the context of Kurdish and Persian. Finally, the researchers have presented the types of derivational processes in both aforementioned languages.
Schroder, Bethell, and The Press: a correction to The Oxford Companion
Authors: Whiteford Peter
Published: November 2023

This note provides a correction to an entry in The Oxford Companion to New Zealand Literature, clarifying Ursula Bethell's relationship with the literary editors of The Press and the publication of her poem, 'The Long Harbour.'
Housing Explorations for Rural-Urban Migrants: For Communities in Guangzhou’s Peri-Urban Areas.
Authors:   , Ou Lisa
Published: November 2023

As China becomes more urbanised, the number of migrant workers from rural areas continues to increase. However, due to ongoing urban development, migrant housing in the major cities (chengzongcun) is being demolished. Moreover, hukou restrictions make it difficult for rural-urban migrants to find adequate housing in the urban host cities. Ultimately, these issues contribute to the social exclusion faced by migrants, which continues to negatively impact their overall well-being and livelihoods. At the same time, urban development plans occurring in peri-urban Guangzhou are taking over older residential settlements. The relationship between various urban development and expansion schemes had, and will, continuously disrupt both the environmental and cultural conditions of what once were villages.

In response to these challenges, this thesis proposes implementing a community housing scheme for rural-urban migrants residing in the peri-urban regions of Guangzhou. The primary objective of this thesis is to create housing that goes beyond fulfilling essential living needs by fostering positive communities and accommodating diverse household structures for rural-urban migrants. Furthermore, this thesis aims to take this housing design scheme to reintroduce Chinese architectural elements on a master plan level, thereby challenging existing urban development plans.

This research is structured in five phases: a literature review, a precedent study analysis, a design framework establishment, developing a housing prototype, and applying the developed prototype to a site. The literature is examined to grasp theoretical perspectives of the social impacts of the hukou system, existing housing environments, multi-generational household dynamics and flexible housing design principles. Three precedent studies are evaluated: A study on the vernacular Tulou dwellings (a traditional form of Chinese collective housing) followed by two contemporary buildings of a similar typology. These studies are conducted to determine the best design principles that enable community living. Specific areas are focused on: circulation, private, semi-public and public spatial relationships in shared spaces, and residential units. Following these studies, a design framework is established encompassing these findings. This framework guides the development of the flexible, communal housing prototype. The developed prototype is adapted to a selected site with prevailing urban development schemes to assess its adaptability to the site’s context. This research has the potential to positively impact the housing conditions of Chinese rural-urban migrants in peri-urban areas, thereby enhancing the overall quality of life for the residents. Moreover, it provides an alternative adaptable urban typology that embraces traditional Chinese architectural elements in a contemporary design.
Agroecologia e produção orgânica: características que distinguem e/ou aproximam os sistemas de produção sustentáveis
Authors: Batista Camila Lais Ramalho , Stoffel Janete
Published: November 2023

O artigo discute as transformações tecnológicas na agricultura, no que diz respeito às suas interações com o meio ambiente, colocando ênfase nos surgimentos de agriculturas sustentáveis e nos conceitos que sustentam a produção agroecológica e a orgânica. Com o avanço tecnológico da modernização agrícola no campo, os movimentos sociais agrícolas voltados à agricultura sustentável passaram a ganhar espaços antes inexistentes. Dentre as práticas agrícolas que consideram os equilíbrios ecológicos naturais estão a agroecologia e a produção orgânica. Para esta reflexão, o trabalho procura analisar quais as características que distinguem e quais aquelas que aproximam os sistemas de produção agroecológico e orgânico. Com base em um levantamento bibliográfico, é desenvolvida a contextualização e embasamento do texto. Observa-se que a agroecologia pode servir como base para a produção orgânica, porém, não se pode cometer o equívoco de confundir ambas, pois o conceito de agroecologia a considera como ciência, que surge a partir da procura por bases teóricas, enquanto a produção orgânica é considerada um sistema de produção. A produção orgânica dispõe de maiores debates e políticas públicas, impulsionadas por perspectivas de avanço a nível de mercado. Estas práticas têm difundido o conceito de produção orgânica, mas o aumento da escala produtiva, bem como o foco apenas na substituição de insumos agroquímicos convencionais por insumos orgânicos, não necessariamente respeita os princípios defendidos pela agroecologia, devendo-se evitar confusões quanto ao emprego correto de cada categoria.
A construção social dos mercados: confiança e reciprocidade em circuitos curtos de comercialização
Authors: Tomazini Cecilia Eduarda Gnoatto , Kiyota Norma , Quinaglia Giovana Diniz Pinto
Published: November 2023

Este trabalho tem objetivo de analisar as relações sociais presentes nas feiras e as suas implicações para organizadores, agricultores familiares e consumidores. Inicia-se com uma contextualização histórica focada nos conceitos de regime agroalimentar e mercados socialmente construídos para compreender as dinâmicas do desenvolvimento rural centrado nas cadeias curtas de comercialização. Paralelamente, discutem-se os processos de institucionalização da confiança e relações interpessoais entre os sujeitos. Para tanto, a pesquisa empírica realizou-se através de um estudo de caso nas Feiras de Produtos Orgânicos e Artesanais dos Bairros de Pato Branco-PR, por meio da aplicação de questionário para 65 consumidores, dos quais selecionou-se 20 e com eles, organizadores e agricultores feirantes efetuou-se um roteiro de entrevista semiestruturado. Deste modo, possibilitou-se entender que as motivações que levam os atores a participarem das feiras são pautadas em questões individuais, como saúde e bem-estar familiar, e mercantis, porém as questões socioambientais e as coletivas firmadas nas relações de reciprocidade e confiança se sobressaem. Portanto, estas relações permitem a cooperação entre os participantes das feiras, resultando na fidelização do consumidor e geração de renda aos agricultores familiares de base orgânica/agroecológica, permitindo a continuidade das feiras.
USE OF INTEGRAL LEUKOCYTE INDICES IN ASSESSING THE EFFECT OF STRESS FACTORS ON GOAT HOMEOSTASIS
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, KALIMULLIN I.F. , SHARAFUTDINOVA E.B. , ZHUKOV A.P.
Published: November 2023

The principle of a quantitative-qualitative approach, which reflects the activity of the organism while distinguishing its specific and non-specific adaptive responses, includes the requirement for quantitative assessment of specific changes in the body. To achieve the research objective, the resources of integral leukocyte indices (ILI) were used to assess the homeostasis of goats during castration, weaning from dams and transfer from pasture to stabling. After percutaneous castration, the index data vary significantly in a day, and in the month following the operation they slowly return to the level of the initial values. The surgical method of castration of goats acts as an unusual extreme stimulus, as it has a damaging effect on the body for a longer period of time. Changes in the blood of kids after weaning from dams were characterised by an increase in leukocytes by 36.84±2.71%, a change in the status of neutrophils, as they increased by 6.85±0.39%. The number of band immature neutrophils increased, but the presence of eosinophils decreased by 1.75±0.19 times, which is one of the indicators of the presence of a moderate stress factor. The transfer of goats to stabling leads to a sharp decrease in impulses from the skeletal muscles, which weakens the activating effect of the reticular formation of the brain on the cerebral cortex. The goat’s body is exposed to extreme stimuli, beyond the limits of everyday influences, and reacts specifically according to the nature of the activeagent. The most pronounced reaction is to open surgical castration, less so to percutaneous castration and then, in descending order: weaning of goats from dams and transfer from pasturing.
CYTOTOXICITY OF PYRANOPYRIDONES WITH TRYPTAMINE FRAGMENT
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, PRZHEVAL’SKIY N.M. , ANIKINA L.V. , GLOBA A.A. , TOKMAKOV G.P. , LAYPANOV R.K. , VERSHINKIN D.A.
Published: November 2023

New derivatives of pyrano[3,2-c]pyridones III 5, 10, 15, 18 were synthesised by threecomponent reaction of pyridonotryptamines I, aromatic aldehydes II and malononitril. Pyridonotryptamines I were synthesised by reaction of tryptamines (these compounds were obtained by Grandberg reaction of arylhydrazines with γ-halogencarbonyl compounds) with 4-hydroxy- 6-methyl-2H-pyran- 2-on. The aromatic aldehydes II 1, 5, 6, 9 are commercially available compounds. Boiling a mixture of compounds I, II and malononitril (molar ratio 1:1.1:1.1) in ethyl alcohol in the presence of triethylamine gives the target compounds III 5, 10, 15, 18. The product yields 44–75%. The structure of pyrano[3,2-c]pyridones with tryptamine fragment III (four compounds) was proved by 1H NMR and confirmed by elemental analysis. Compounds III 1–4, 6–9, 11–14, 16 and 17 were synthesised earlier by a similar procedure. The cytotoxicity of the synthesised compounds III 1–18 was determined in vitro using the MTT test on human cell cultures A549 (lung carcinoma) and HCT116 (colorectal carcinoma). Camptothecin and daunorubicin were used as reference drugs. The value of the concentration inducing 50% inhibition of the cell growth (IC50, μM) was determined from the dose-response curves using GraphPad Prism 9 software. Compounds III 3 (R1=R2=Br, Ar=2,5-di-OMe-С6Н3,) III 4 (R1=R2=Br, Ar=4-F-С6Н4), III 6 (R1=Ме, R2=Н, Ar=2,4,5-tris-OMe-С6Н2), III 13 (R1=R2=Br, Ar=Ph), III 14 (R1=R2=Br, Ar=2,3-di-OMe-С6Н3) and III 16 (R1=R2=Br, Ar=Py) showed the best results for A549 and HCT116 cultures. The effect of the most active compounds III 3 and III 4 on the cell cycle and apoptosis was studied on Jurkat cell culture (human acute T-cell leukemia). Compounds III 3 and III 4 showed significant cytotoxicity against the Jurkat line in the resazurin test – 1.47 ± 0.06 and 4.56 ± 0.19 μM, respectively, comparable to the cytotoxicity of the reference drug camptothecin of 1.24 ± 0.05 μM. Based on the flow cytometry results, it is suggested that the effect is manifested by some (possibly reversible) cell cycle arrest in the presynthetic phase.
Towards Optimizing Caesarean Section: Robson Ten Group Analysis of Caesarean Section and It’s Determinants in a Tertiary Hospital in South-South, Nigeria
Authors: Makinde Olakunle Ifeoluwa , Osegi Nkencho
Published: November 2023

Background: To optimize caesarean section (CS), Robson classification is useful for audit of CS rates within and across hospitals and regions. Valid conclusions are also possible by analyzing other characteristics of parturients that determine CS rates based on Robson groups. This study aimed to analyzed CS rate and determine the impact of parturients’ age and booking status on delivery by CS based on Robson classification. 
Subjects and Method: A cross-sectional descriptive study that classified parturients into Robson 10-groups using data from hospital records at the Federal Medical Centre Yenagoa (FMCY) in Bayelsa State, south-south, Nigeria. The dependent variable was mode of delivery. The independent variables were parturients’ age and booking status by Robson group. The study instrument was a predesigned spreadsheet used to collect real-time relevant data on all deliveries from patients’ hospital records. Descriptive statistics were presented using frequencies, percentages, mean and standard deviation. Chi-square, Exact test and logistic regression were used to determine association of parturients’ age and booking status with mode of delivery. Level of significance was p <0.05.
Results: There were 556 deliveries during the study period and 269 CSs, giving a CS rate of 48.4%. Robson group 3 made the highest (27.9%) contribution to CS rate, followed by group 10 (22.3%), 5 (13.8%) and 1 (11.2%). The commonest indication for CS was cephalopelvic disproportion, followed by severe preeclampsia. Booked parturients in Robson groups 1 and 3 had 61.0% reduced odd (OR= 0.39; 95% CI = 0.15 to 0.99; p = 0.050) and 74.8% reduced odd (OR= 0.25; 95% CI= 0.14 to 0.45; p < 0.001) of delivery by CS, respectively.  
Conclusion: The CS rate at the FMCY was contributed largely by group 3, 10, 5 and 1 parturients. Using Robson classification, CS rate can be focused to targeted intervention to optimize CS. 
Keywords: caesarean section rate, hospital, Robson classification, Robson 10-group.
Correspondence: Olakunle Ifeoluwa Makinde. Department of Obstetrics and Gynaecology, Federal Medical Centre Yenagoa, Bayelsa State, Nigeria. Email: olakunleife@gmail.com. Mobile: +2348032136315.
COMBINED MODE OF TEACHING RUSSIAN AS A FOREIGN LANGUAGE IN THE POST-PANDEMIC ERA. LEADING TRENDS AND NEW CHALLENGES
Authors:   Lomonosov Moscow State University, Ermakova Ol’ga B. , Klobukova Lyubov’ P. ,   Lomonosov Moscow State University, Chernyshenko Elena A. ,   Lomonosov Moscow State University
Published: November 2023

By the example of teaching Russian as a foreign language the article analyzes how distance learning methods applied during the COVID-19 pandemic impacted the face to face learning approaches and influenced both students and teachers after the return to the classroom environment. On the one hand, there is a significantly increased role of information and communication technologies, which make it possible to model authentic language environment, to equip training courses with interactive materials, to increase the share of independent work of students, to increase their motivation and emotional involvement in the learning process. On the other hand, a significant change in the learning experiences and classroom skills of a new generation of students is being documented. The authors investigate the challenges encountered by learners of Russian as a foreign language during the pandemic era in their reading, listening, writing, and speaking practices. The authors conclude that the period of distance language learning impacted significantly on its face-to-face form, which, in turn, cannot but affect the methodology of teaching Russian as a foreign language. The most pressing task at present for instructors and teaching professionals is understanding how to use the experience acquired during the pandemic period for improving both face to face and combined learning practices in the most effective manner. As well as to find a reasonable balance in the use of e-learning tools that would allow to successfully overcome the pedagogical challenges posed by the recent return to face-to-face learning.
FEATURES OF THE LINGUODIDACTICAL APPROACH TO WORKING WITH TEXT WHEN LEARNING THE RUSSIAN LANGUAGE OF INOPHONES - FUTURE INTERNATIONAL LAWYERS
Authors:   Russian State University for the Humanities, Nedosugova Anastasia B.
Published: November 2023

The article presents a functional and communicative model of working with professional text in the process of assimilating and producing a language thesaurus of international legal topics in Russian in a foreign audience at an advanced stage of training. The purpose of the study is to develop an integrated methodically grounded approach to the process of teaching the language of a specialty, in our case – the language of a future specialist in the field of international law and international relations. The research is based on an interdisciplinary approach to the studied problematics, since the formation of professional competencies among foreigners occurs in Russian, which is a means of obtaining a specialty. The general scientific methods of cognition used in this study include observation and analysis of the text and linguistic material, an experiment to test the developed methodology, and analysis of the results obtained. The article substantiates an integrated approach to the study of professionally oriented text, describes the grammatical, lexical and conceptual difficulties characteristic of professional non-adapted texts and hindering their production by foreign students. The selected lexical material, on the basis of which the analysis of the integrated approach was carried out, was not previously included in such studies. In the conclusion of the article, the results of the experimental final testing of students are given, indicating the productivity of the described complex methodological training model.
CONSTRUCTION “WHICH OF NP[GEN] NP[NOM]”. SEMANTICS, SYNTACTICS, PRAGMATICS
Authors:   Russian State University for the Humanities, Astakhova Yana A.
Published: November 2023

In the article analyzes the semantic, syntactic and pragmatic features of the construction “Which of NP[gen] NP[nom]”, that is implemented mainly within the framework of the dialogue in the model of which of the PronPers[gen] NP[nom]. The most frequent placeholder of the component with the pronoun is the word me. Among the placeholders of the second variable component there are words indicating the social status of the object or its social role; a negative subjective assessment is emphasized by the intonation of SF when using IK-2; from the point of view of pragmatics, SF is used in indirect expressive speech acts.
PREFIXAL PARONYMS IN TEACHING RUSSIAN AS A FOREIGN LANGUAGE
Authors:   Russian State University for the Humanities, Yakunina Daria V.
Published: November 2023

The article presents а research on paronymy in teaching Russian as a foreign language. By paronyms we mean words that have a different form due to their affixes and at the same time have a similar meaning due to their common root. Not being full synonyms, they are often used synonymously in speech communication and thus in certain contexts are regarded as mistakes in the field of speech culture. The phonetic similarity in paronyms is caused by the unity of the root and is in most cases supported by the phonetic resemblance of affixes. Paronyms are studied both within the framework of linguistic studies that reveal the systemic features of that linguistic phenomenon, and in textbooks on speech culture, where the emphasis is made on identifying and preventing mistakes in speech usage. Based on the analysis of examples of paronymic mistakes made by foreigners in Russian Learner Corpus, the article presents a classification of prefixal verb paronymy confusions, supplementing the list of mistake types described in existing studies. In accordance with the identified list, additions to the methodological recommendations for working with paronyms in teaching Russian as a foreign language are proposed.
Kuat Tekan Beton Ringan Non-Pasir Pada Pemanfaatan Batu Karang Simeulue Sebagai Alternatif Agregat Kasar
Authors: Wesli Wesli , Fuadi Adlianis , Chandra Yovi
Published: November 2023

Abstrak

 

Batu karang mati banyak ditemukan di pulau Simeulue dan tersebar hamper disetiap pesisir pantainya. Dalam hal Pembangunan daerah, penggunaan bahan penyusun beton seperti agregat kasar sering kali didatangkan dari luar pulau sehingga harganya menjadi mahal. Dalam penelitian ini ingin memanfaatkan batu karang mati sebagai agregat kasar pada campuran beton ringan non-pasir dan beton normal. Tujuan dari penelitian adalah untuk mengetahui besarnya variasi batu karang yang dapat dimanfaatkan untuk agregat kasar pada beton ringan non-pasir dan beton normal. Perencanaan campuran beton dibuat berdasarkan SNI 7656:2012. Faktor air semen untuk semua variasi adalah 0,40. Pengujian kuat tekan dan porositas daerahdilakukan pada umur beton 28 hari. Berdasarkan hasil analisis data pada peneltian ini dinyatakan bahwa Agregat batu karang Simeulue ini tidak bisa dimanfaatkan dalam campuran beton ringan non-pasir, akan tetapi dapat dimanfaatkan dalam campuran beton normal yang memenuhi kriteria untuk beton struktural minimal kuat tekan 17 MPa.

 

Kata kunci: Batu karang, Beton non-pasir, Beton ringan, Beton ringan non-pasir, Kuat tekan beton

 

 

Abstract

 

Dead corals are found on Simeulue Island and are scattered on almost every coast. In terms of regional development, the use of concrete constituent materials such as coarse aggregate is often imported from outside the island so the price is expensive. In this study, we wanted to use dead coral rock as a coarse aggregate in a mixture of non-sand and normal lightweight concrete. The purpose of this study was to determine the variety of rocks that can be used for coarse aggregate in non-sand lightweight concrete and normal concrete. Concrete mix planning is based on SNI 7656:2012. Water cement factor for all variations is 0.40. The compressive strength and regional porosity tests were carried out at the age of 28 days of concrete. Based on the results of data analysis in this study it was stated that the Simeulue rock aggregate cannot be used in non-sand lightweight concrete mixtures, but can be used in normal concrete mixtures that meet the criteria for structural concrete with a minimum compressive strength of 17 MPa.

 Keywords: Rock, No fines concrete, Lightweight concrete, Non-sand lightweight concrete, Compressive strength
Fibroxantoma atípico: serie de casos
Authors: González Franco Gabriella , Herrera Hugo Eduardo , Acosta-de Haart Álvaro , Pérez-Cely Héctor Camilo
Published: November 2023

El fibroxantoma atípico (FXA) es un tumor que aparece en pacientes de edad avanzada, con antecedente de fotoexposición, con mayor incidencia de casos en cabeza y cuello. Es una neoplasia dérmica, no presenta invasión de tejido subcutáneo o linfovascular ni perineural. Son tumores conformados por células histiocitoides, fusiformes, epitelioides y gigantes multinucleadas con núcleos pleomórficos. No existen cifras epidemiológicas respecto a la incidencia en Colombia, sin embargo se ha reportado que la incidencia del FXA en España es de 0,59 casos/100,000 habitantes, por ende se reconoce que es una lesión tumoral de baja incidencia. (1) A continuación se realiza un reporte de 3 casos de pacientes quienes presentaron un fibroxantoma atípico en diferentes localizaciones anatómicas.
Retroniquia sin paroniquia: un reto diagnóstico. Parte 2
Authors: Botello Mojica Heliana Marcela , Bonelo Castro Angie Daniela , Chamorro Enriquez Julian Andres , Jaramillo Ayerbe Felipe
Published: November 2023

La retroniquia es el enclavamiento de la lámina ungueal en el pliegue ungueal proximal donde se presentan dos o más generaciones de láminas ungueales superpuestas bajo dicho pliegue.  Está principalmente relacionada con micro traumas locales. El diagnóstico es clínico y en casos difíciles es útil el uso de la ecografía para la confirmación y/o descarte de otras patologías. El tratamiento definitivo es la avulsión quirúrgica de la lámina ungueal. Es frecuentemente infradiagnosticada ya que su forma de presentación más común es la paroniquia crónica que no responde a los tratamientos convencionales; sin embargo, cuando no se manifiesta de esta manera, como en nuestro caso, el enfoque clínico se dificulta por lo cual se pueden emplear ayudas imagenológicas que permitan un mejor abordaje de la patología.
¿Cómo liderar y consolidar un servicio y un equipo de dermatología? Una visión personal
Authors: Peñaranda Contreras Elkin
Published: November 2023

En cualquier actividad de la vida, es un gran compromiso y hasta un acto irreverente dar recomendaciones o consejos a otros partiendo de la experiencia propia, más cuando dicha experiencia está cargada de errores y de aciertos que nos llevaron a lo que otros ven hoy. Cuando hablamos de nuestras experiencias, por lo general, seleccionamos lo que consideramos aciertos más que aquellos errores que también forjaron los resultados.
Perubahan perilaku sosial pada santri dalam menggunakan gadget di pesantren al-munawarah
Authors: Maulida Matondang Atiqah Yunita Putri , Desky Ahmed Fernanda
Published: November 2023

Penelitian ini bertujuan untuk mengetahui perubahan perilaku sosial santri dalam menggunakan gadget pada Pesantren Al-Munawarah Kecamatan Kotanopan Kabupaten Mandailing Natal. Sebagai landasan teori dalam menganalisis persoalan pada penelitian kualitatif ini, digunakan teori-teori tentang paham perubahan perilaku, teknologi Gadget, dan perkembangan sosial. sehingga peneliti dituntut untuk memperoleh data dan informasi dengan melakukan wawancara, observasi dan dokumentasi secara mendalam. Penelitian ini menggunakan pendekatan kualitatif yang bersifat deskriptif. Informan pada penelitian yaitu kepala Pesantren dan guru-guru di Pesantren Al-Munawarah Kotanopan. Teknik pengumpulan data yang digunakan peneliti ialah melakukan wawancara, observasi dan dokumentasi, dengan menggunakan pendekatan studi fenomenologi, yaitu peneliti berusaha untuk mencari makna perubahan perilaku sosial santri dalam penggunaan gadget. Analisis data yag digunakan pada penelitian adalah analisis deskriptif, yaitu meringkas seluruh data yang telah dikumpulkan dari hasil wawancara. Hasil penelitian ini menunjukkan bahwa gadget bisa sangat bermanfaat bagi perkembangan sosial jika digunakan secara tepat, dan gadget juga bisa memberikan efek negatif bagi perkembangan sosial jika santri mengalami kecanduan gadget.
Perilaku dan gaya hidup komunitas salafi pada masyarakat sekitar pesantren al guroba
Authors: Syahfitri Ade , Jailani Muhammad
Published: November 2023

Pendidikan tidak hanya sekadar transfer pengetahuan, tetapi juga berperan dalam membentuk pola pikir, sikap, dan tindakan individu serta kelompok dalam masyarakat, Tujuan penelitian ini adalah untuk memahami perilaku komunitas dan gaya hidup sosial Salafi di Pesantren al-Ghuroba' Aek Songsongan dalam berinteraksi dengan masyarakat. Penelitian ini mengadopsi pendekatan kualitatif untuk memahami Perilaku dan gaya hidup sosial komunitas Salafi di sekitar Desa Aek Songsongan, dengan fokus pada Pesantren Al-Ghuroba Aek Songsongan, Kabupaten Asahan, Sumatera Utara. Pengumpulan data dilakukan dengan cara observasi langsung, wawancara, dan studi dokumentasi, penelitian ini mengungkapkan pola perilaku dan gaya hidup unik yang melekat pada komunitas Salafi, termasuk praktik keagamaan dan interaksi sosial yang khas. Alhasil menunjukkan bahwa komunitas Salafi membentuk identitas dan gaya hidup yang tercermin dalam pendekatan agama yang kuat dan penekanan pada pemahaman tauhid yang murni. Gaya hidup dan perilaku sosial mereka berakar pada pemahaman dan pandangan ajaran Islam yang dianggap autentik dan menjadi ciri khas dari pesantren Al-Guroba.
The resolution of customary community land rights issues based on government regulation no. 18 of 2021 and its relevance to the constitution in indonesia
Authors: Aprido Rizki , Fatimah Fatimah
Published: November 2023

This research aims to find a solution to the issue of customary community land rights concerning the usurpation of customary land rights in the Percut Sei Tuan District, Deli Serdang Regency. The purpose of this research is to determine the direction of Government Regulation No. 18 of 2021 in shaping policies regarding the resolution of customary land rights of indigenous communities. The research method used in this study is a normative juridical approach conducted by examining secondary data, both primary legal materials (primary sources) and secondary legal materials (secondary sources). The primary legal materials used consist of regulations related to the issues under investigation. The research approach used by the author in this paper is a qualitative approach to examine the problem formulations present in this paper. The nature of the research used by the author is normative research that tests the topic in this paper. The research findings indicate that the orbit of Government Regulation No. 18 of 2021 in shaping policies for resolving disputes regarding the customary land rights occupied by PTPN II. PTPN II is considered not in line with and deviates from the applicable laws, given that the actions of PTPN II have obstructed the indigenous communities from realizing their livelihoods based on their customary land rights. Various efforts have been made to curb the encroachment on customary land in Percut Sei Tuan, but their activities continue due to protection from certain law enforcement authorities, preventing the people of Percut Sei Tuan from benefiting from their customary land rights.
Teacher Readiness for Digital Transformation
Authors: Turrohmah Hamimah , Suryanto Suryanto
Published: November 2023

The acceleration of digitalization in the field of education during the pandemic requires teachers to be quick to adapt. This study aims to describe teacher readiness in the form of mental readiness, self- readiness, and intelligence readiness to face digital transformation in terms of internal and external factors. The research methodology used is descriptive qualitative with data collection techniques, namely observation, interviews, and documentation conducted to six teachers from various school levels in Surabaya. The results of this study indicate that the readiness of teachers in the form of mental readiness, self, and intelligence to face digital transformation is good. However, there are obstacles in carrying out teacher activities using digital devices and media such as virtual media, web- based learning platforms, and the use of IoT (Internet of Things) caused by low adaptability. In overcoming this, the school's efforts are to provide digital literacy supplies and provide adequate digital technology. It is suggested that there is a need for a peer-to-peer pair learning program to speed up the adaptation process.
Evaluasi kepuasan peserta workshop aplikasi digital AUM seri PTSDL berbasis web di Sumatera Barat
Authors: Ifdil Ifdil , Zola Nilma , Fadli Rima Pratiwi , Putri Yola Eka , Syahputra Yuda , Fitria Linda
Published: November 2023

Di era milenial, perkembangan teknologi informasi telah mengubah lanskap pendidikan, dan guru Bimbingan dan Konseling (BK) diharapkan untuk terus meningkatkan kompetensinya. Tujuan penelitian ini adalah untuk mengevaluasi tingkat kepuasan peserta terhadap Workshop Pengabdian Masyarakat Implementasi Aplikasi Digital Pengolahan AUM Seri PTSDL Berbasis Web bagi Guru Bimbingan dan Konseling SLTA di Sumatera Barat, serta untuk menganalisis perbedaan tingkat kepuasan berdasarkan gender dan domisili peserta. Penelitian ini menggunakan pendekatan kuantitatif dengan metode deskriptif untuk mengevaluasi Workshop Pengabdian Masyarakat Implementasi Aplikasi Digital Pengolahan AUM Seri PTSDL Berbasis Web Bagi Guru Bimbingan dan Konseling SLTA di Sumatera Barat. Sampel terdiri dari 80 partisipan yang tersebar di berbagai daerah di Sumatera Barat. Setelah penyaringan data, hanya 77 data yang digunakan dalam analisis. Temuan pada penelitian menunjukkan Workshop Pengabdian Masyarakat Implementasi Aplikasi Digital Pengolahan AUM Seri PTSDL Berbasis Web Bagi Guru Bimbingan dan Konseling SLTA di Sumatera Barat berhasil dengan sangat baik. Peserta sangat puas, dan sebagian besar sangat puas. Implikasinya adalah bahwa data yang dikumpulkan juga dapat digunakan sebagai dasar untuk perencanaan yang lebih strategis dalam pengembangan kegiatan serupa di masa depan.
Revitalisasi pendidikan karakter: multimedia interaktif berbasis articulate storyline sebagai solusi modern
Authors: Kurniawati Devi Ayu , Erwinda Lira
Published: November 2023

Dalam masyarakat yang semakin terkoneksi secara digital, anak-anak terpapar pada beragam konten online, dan permainan online melalui samrtphone. Akan tetapi, teknologi adalah seperti dua mata pisau, memiliki potensi untuk memberikan manfaat besar sekaligus membawa risiko besar, tergantung pada cara kita menggunakannya. Tujuan penelitian ini adalah menguji keefektivan produk multimedia interaktif berbasis articulate storyline efektif untuk meningkatkan pendidikan karakter siswa Sekolah Dasar (SD). Penelitian pengembangan multimedia interaktif ini menggunakan desain pengembangan ADDIE. Sampel penitian ini 30 orang siswa Sekolah Dasar (SD) Negeri Panancangan 5 Serang, yang diperoleh melalui purposive sampling. Instrumen yang digunakan yaitu angket karakter dengan model skala Likert. Data dianalisis menggunakan teknik statistik parametrik yang menggunakan wilcoxon signed-rank test. Hasil temuan menunjukkan multimedia interaktif berbasis articulate storyline efektif untuk meningkatkan karakter siswa SD, dibuktikan dari perbedaan yang signifikan pendidikan karakter sebelum dan sesudah diberikan multimedia interaktif berbasis articulate storyline. Implikasi dari temuan ini dapat membantu dalam pengambilan keputusan terkait kurikulum dan metode pengajaran yang lebih baik.
Effect of whey protein on thickness, water vapour transmission rate, and water content of gelatin film
Authors: Fahrullah Fahrullah , Rahmawati Lilik , Kartika Kartika , Ulkiyah Kalisom , Yulianto Wahid
Published: November 2023

Packaging is a tool used to protect products from physical damage; edible films can improve food quality and reduce plastic-based packaging materials. This study aimed to determine the effect of adding whey protein concentration on gelatin edible film thickness, water vapour transmission rate, and moisture content. This research used a completely randomized design with 4 treatments and 3 replications. The treatments consisted of P0 (0 g whey: 2 g gelatin), P1 (0.05 g whey: 2 g gelatin), P2 (0.10 g whey: 2 g gelatin), P3 (0.15 g whey: 2 g gelatin). The addition of whey protein had a significant effect (P<0.01) on the thickness of the gelatin film. However, no significant effect (P>0.05) was found on the water vapour transmission rate and moisture content. Nonetheless, employing whey protein can reduce the water vapour transmission rate and increase the moisture content of edible gelatin film. The findings suggest that incorporating whey protein can enhance the physicochemical properties of gelatin films. Using whey protein at a concentration of 0.05 g is deemed the optimum treatment.
Effects of gamal leaf extract (Gliricidia sepium Jacq.) on body weight and internal organ performance of mice (Mus musculus L.)
Authors: Harlis Wa Ode , Malik Nurhayu , Luvita Luvita , Resman Resman
Published: November 2023

Gamal leaves (Gliricidia sepium Jacq.) contain toxic compounds that have the potential to act as vegetable rodenticides, such as alkaloids, tannins, dicumerol, and hydrogen cyanic acid (HCN). Coumarin compounds can bind vitamin K, disrupt the circulatory system, and damage liver cells. The compounds dicumerol and warfarin are used as rat poison because of their anticoagulant properties, which prevent blood clots in the heart. Alkaloid and tannin compounds can damage liver cells through liver necrosis and bleeding in the digestive system. This study aims to determine the effect of Gamal leaf extract on body weight and internal organ performance in mice (Mus musculus L.). The experimental research method is based on a Completely Randomized Design (CRD) pattern. A total of 16 mice weighing 20-22 grams consisting of 4 treatments, namely A0 (water control), A1 (extract 10 mg/g BW), A2 (extract 15 mg/g BW) and A3 (extract 20 mg/g BW). The extract was given orally for 14 days, and body weight was measured every 3 days to obtain data on changes in body weight (PBB). At the end of the treatment, the mice were sacrificed using chloroform and then dissected to observe the performance of the liver, kidney and heart organs in color appearance and organ weight. Quantitative data were analyzed using one-way ANOVA and further DMRT test α=0.05. The research showed that mice's mean change in body weight (PBB) decreased significantly as the dose of Gamal leaf extract increased. The percentage of liver organ weight (BOH), kidney organ weight (BOG), and heart organ weight (BOJ) decreased as the dose of Gamal leaf extract increased. The research results concluded that Gamal leaf extract caused color changes in the internal organs of mice and significantly affected the percentage change in body weight (PBB) and internal organ weight (BOD) of mice along with increasing doses of Gamal leaf extract.
Decoding the chemical clues: The role of advancements in forensic toxicology
Authors: Sandeep K Vaishnav  , R. D. Ahirwar  , Rajesh Mishra
Published: November 2023

Forensic toxicology, a crucial discipline in criminal investigations, has undergone significant advancements in recent years. This article delves into the realm of emerging techniques, analytical methods, and innovative applications that are revolutionizing the field. Advanced analytical techniques, such as high-resolution mass spectrometry, have enhanced the sensitivity and specificity of drug detection, enabling the identification of trace-level substances, including novel psychoactive substances (NPS). Emerging analytical methods, such as non-targeted screening approaches and biosensors, offer rapid and portable solutions for on-site drug detection. The article highlights the innovative applications of forensic toxicology, extending beyond traditional analyses. In postmortem toxicology, improved techniques aid in determining cause of death and assessing time of drug administration. In driving under the influence evaluation, roadside screening devices and pharmacodynamic models provide valuable insights into drug impairment. And in drug abuse monitoring and treatment, toxicological data informs public health interventions and treatment strategies. The article concludes by emphasizing the importance of continuous advancements in forensic toxicology to stay ahead of the growing complexity of toxicological challenges and address the ethical considerations surrounding advanced techniques. It underscores the significance of collaboration between forensic toxicologists, analytical chemists, pharmacologists, and clinicians to foster knowledge sharing and accelerate progress in this vital field.
Pendidikan Agama Islam Berwasasan Multikultural Dalam Menanamkan Toleransi Beragama Siswa
Authors: Rofikoh Sari Ifka Ayu , Romdloni Romdloni , Hasan Sholeh
Published: November 2023

Indonesia merupakan negara multikultural terbesar, hal ini dapat dilihat dari kondisi sosial, budaya, agama, maupun geografis yang beragam dan luas Keragaman agama dan kepercayaan. Penelitian ini bertujuan untuk: 1) Mendeskripsikan bentuk pembelajaran pendidikan agama Islam berwawasan multikultural dalam menanamkan toleransi beragama siswa di SMP Negeri 1 Belitang III; 2) Mendeskripsikan bagaimana Pendidikan agama Islam Berwawasan multikultural dalam menanamkan toleransi beragama siswa di SMP Negeri 1 Belitang III; 3) Mendeskripsikan hambatan dalam Pendidikan agama Islam Berwawasan multikultural dalam menanamkan toleransi beragama siswa di SMP Negeri 1 Belitang III. Pendekatan yang digunakan dalam penelitian ini adalah field research atau penelitian lapangan. Penelitian ini menggunakan metode kualitatif. Hasil penelitian menunjukan bahwa bentuk Pendidikan agama Islam Berwawasan multikultural dalam menanamkan toleransi beragama siswa adalah melalui kegiatan di dalam kelas dan di luar kelas. Implementasi pembelajaran tersebut menggunakan beberapa upaya dalam pelaksanaannya, di antaranya yaitu memberikan kebebasan dan tidak membeda-bedakan siswa, menyisipkan nilai-nilai toleransi dalam setiap pembelajaran. Hal tersebut di atas memberi dampak baik bagi SMP Negeri 1 Belitang III, yaitu terwujudnya sikap saling menghargai. Selain itu segala kegiatan sekolah juga menjadi harmonis (tidak ada konflik) dan penuh akan nilai-nilai toleransi.
HUBUNGAN UMUR DAN PENDIDIKAN IBU DENGAN RENDAHNYA CAKUPAN PEMBERIAN VITAMIN A DI POSYANDU EDELWEIS KECAMATAN ULUBELU KABUPATEN TANGGAMUS TAHUN 2020
Authors: Tantria Meylina , Desni Sagita Yona
Published: November 2023

Suplementasi vitamin A merupakan Program Nasional untuk mencegah kekurangan vitamin A diantara anak-anak Indonesia. Tinggi atau rendahnya cakupan kapsul vitamin A terkait dengan berbagai faktor yang spesifik menurut karakteristik individu ibu sendiri seperti faktor umur dan pendidikan ibu yang berpengaruh terhadap perubahan perilaku ibu dalam pemberian kapsul vitamin A. Tujuan penelitian ini adalah untuk mengetahui hubungan umur dan pendidikan ibu dengan rendahnya cakupan pemberian vitamin A pada balita di Posyandu Edelweis Desa Air Abang Kecamatan Ulubelu Kabupaten Tanggamus tahun 2020.

Metode dalam penelitian ini adalah penelitian analitik kuantitatif dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh ibu yang memliki balita di Desa Air Abang Kecamatan Ulubelu dengan jumlah sampel sebanyak 69 orang dengan teknik pengambilan sampel secara random sampling. Analisis yang digunakan adalah univariat dan bivariat menggunakan uji chi square.

Hasil penelitian membuktikan ada hubungan umur (p-value = 0,007 dan nilai OR = 4,500) dan pendidikan ibu (p-value = 0,044 dan nilai OR = 3,084) dengan rendahnya cakupan pemberian vitamin A pada balita di Posyandu Edelweis Desa Air Abang Kecamatan Ulubelu Kabupaten Tanggamus tahun 2020. Saran penelitian agar petugas kesehatan hendaknya terus meningkatkan penyuluhan dan konseling dengan cara menyediakan leaflet dan pamflet tentang pentingnya pemberian vitamin A bagi balita, sehingga terjadinya kekurangan vitamin A dapat dihindari sejak dini.