bluuebunny/crossref_metadata_2025 huggingface dataset:
High-resolution ultrasonography for early diagnosis of neural impairment in seropositive leprosy household contacts
Authors: Luppi Andrea De Martino , Ferreira Guilherme Emilio , Prudêncio Denis Luiz , Antunes Douglas Eulálio , Araújo Lúcio , dos Santos Diogo Fernandes , Nogueira-Barbosa Marcello Henrique , Goulart Isabela Maria Bernardes
Published: May 2023

Leprosy household contacts (HC) represent a high-risk group for the development of the disease. Anti-PGL-I IgM seropositivity also increases the risk of illness. Despite significant advances in leprosy control, it remains a public health problem; and early diagnosis of this peripheral neuropathy represents one of the main goals of leprosy programs. The present study was performed to identify neural impairment in leprosy HC by analyzing differences in high-resolution ultrasonographic (US) measurements of peripheral nerves between leprosy HC and healthy volunteers (HV). Seventy-nine seropositive household contacts (SPHC) and 30 seronegative household contacts (SNHC) underwent dermato-neurological examination and molecular analysis, followed by high-resolution US evaluation of cross-sectional areas (CSAs) of the median, ulnar, common fibular and tibial nerves. In addition, 53 HV underwent similar US measurements. The US evaluation detected neural thickening in 26.5% (13/49) of the SPHC and only in 3.3% (1/30) among the SNHC (p = 0.0038). The CSA values of the common fibular and tibial nerves were significantly higher in SPHC. This group also had significantly greater asymmetry in the common fibular and tibial nerves (proximal to the tunnel). SPHC presented a 10.5-fold higher chance of neural impairment (p = 0.0311). On the contrary, the presence of at least one scar from the BCG vaccine conferred 5.2-fold greater protection against neural involvement detected by US (p = 0.0184). Our findings demonstrated a higher prevalence of neural thickening in SPHC and support the role of high-resolution US in the early diagnosis of leprosy neuropathy. The combination of positive anti-PGL-I serology and absence of a BCG scar can identify individuals with greater chances of developing leprosy neuropathy, who should be referred for US examination, reinforcing the importance of including serological and imaging methods in the epidemiological surveillance of leprosy HC.
Prevalence of post-vaccine side effects among COVID-19 immunized community of Southern Pakistan
Authors: Qureshi Ali , Syed Sulaiman Syed Azhar , Rehman Wajiha , Mehmood Asim , Idrees Sumaira , Kumar Narendar
Published: May 2023

Background

The response to the vaccine may vary among individuals. Hence, it is important to know how often individuals experience side effects after immunization against COVID-19.

Objective

This study aimed to assess the incidence of side effects following COVID-19 vaccination across different vaccine recipients in Southern Pakistan and identify the potential factors associated with these side effects in the population.

Methods

The survey was conducted across Pakistan through Google-forms Links from August to October 2021. The questionnaire included demographic information and COVID-19 vaccine information. Chi-square (x2) was performed for comparative analysis to check the significance level with P <0.05. The final analysis included 507 participants who had received COVID-19 vaccines.

Results

Of the total 507 COVID-19 vaccines recipients, 24.9% received CoronaVac, 36.5% received BBIBP-CorV, 14.2% received BNT162b2, 13.8% received AZD1222, and 10.7% received mRNA-1273. The most prominent side effects after the first dose were fever, weakness, lethargy, and pain at the site of injection. Moreover, the most commonly reported side effects after the second dose were pain at the injection site, headache, body ache, lethargy, fever, chills, flu-like symptoms, and diarrhea.

Conclusion

Our results suggested that the side effects due to COVID-19 vaccination can vary between the first and second doses and type of COVID-19 vaccine. Our findings suggest continuing monitoring of vaccine safety and the importance of individualized risk-benefit assessment for COVID-19 immunization.
CEG: A joint model for causal commonsense events enhanced story ending generation
Authors: Zhang Yushi , Yang Yan , Gu Ming , Gao Feng , Chen Chengcai , He Liang
Published: May 2023

With the success of pre-trained language models, the performance of story ending generation has been dramatically improved while remaining challenging due to the lack of commonsense reasoning ability. Most previous works mainly focus on using commonsense knowledge to enhance the implicit correlations between words but ignore the hidden causality of sentences or events. In this paper, we proposeCausal commonsenseEnhanced joint model for story endingGeneration (CEG), which incorporates causal commonsense events knowledge to generate a reasonable story ending. Specifically, we first develop a commonsense events inference model trained on GLUCOSE, which converts static knowledge into a dynamic generation model to discover unseen knowledge. It uses prompts to produce various commonsense events behind the stories as pseudo-labels of the dataset. Then, we propose a joint model for the causal events inference task and the story ending generation task to inject inference knowledge into the generation, which consists of a shared encoder, an inference decoder, and a generation decoder. In the causal events inference task, we use the shared encoder and the inference decoder to reason the causal events behind each sentence of the story context to help the model better understand the story and provide long-distance dependencies for the story ending generation. In story ending generation, we combine the hidden states of the causal events with the story context to generate the story ending by the shared encoder and the generation decoder. We jointly train the model on two tasks so that the generation decoder produces the story endings that better match the clues. Experimental results on the ROCStories dataset show that our model outperforms the previous works, demonstrating the effectiveness of the joint model and the generated causal events.
Service user and stakeholder engagement in maternal and newborn health research in low- and middle-income countries: A systematic review protocol
Authors: Singh Devendra Raj , Sah Rajeeb Kumar , Simkhada Bibha , Darwin Zoe
Published: May 2023

Background

Service user and stakeholder engagement have been widely considered as key aspects in translating knowledge into realistic policies and practices. However, there is a paucity of accumulative evidence about service user and stakeholder engagements in maternal and newborn health (MNH) research in low- and middle-income countries (LMICs). Therefore, we aim to systematically review the existing literature that includes service user and stakeholder engagement in maternal and newborn health research in low- and middle–income countries.

Materials and methods

The design of this protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA-P) checklist. We will systematically run the search in PubMed/MEDLINE, PsycINFO, Scopus, Science Direct, and CINAHL to obtain relevant peer-reviewed literature published between January 1990 and March 2023. The list of extracted references will be screened by applying the study inclusion criteria, and eligible studies will be processed for further evaluation before being included in the review. The quality of the selected study will be assessed using the critical appraisal skills program (CASP) checklists and the Mixed Method Appraisal Tool (MMAT) checklist. A narrative synthesis will be used to synthesised results from all the included studies.

Discussion and conclusion

To the best of our knowledge, this systematic review will be the first synthesised evidence on service user and stakeholder engagement in maternal and newborn health research in low- and middle-income countries. The study highlights the importance of service user and stakeholder roles in designing, implementing, and evaluating maternal and newborn health interventions in resource-poor settings. The evidence from this review is expected to be useful for national and international researchers/stakeholders for practising meaningful and effective ways of engaging users and stakeholders in maternal and newborn health research and related activities. The PROSPERO registration number is CRD42022314613.
Impact of the cost-of-living crisis on the nature of attempts to stop smoking and to reduce alcohol consumption in Great Britain: A representative population survey, 2021–2022
Authors: Jackson Sarah E. , Cox Sharon , Shahab Lion , Brown Jamie
Published: May 2023

Background

Smoking and excessive drinking place a strain on household budgets. We aimed to examine the impact of the cost-of-living crisis in Great Britain on the nature of smoking cessation and alcohol reduction attempts, and explore changes in health professionals offering support.

Methods

Data were from 14,567 past-year smokers and high-risk drinkers (AUDIT-C ≥5) participating in monthly representative surveys, January-2021 through December-2022. We estimated time trends in cost as a motive driving the most recent (smoking cessation/alcohol reduction) attempt, use of paid or evidence-based support, and receipt of GP offer of support for smoking cessation or alcohol reduction, and tested for moderation by occupational social grade.

Results

The proportion of attempts motivated by cost did not change significantly over time among smokers (25.4% [95%CI = 23.8–26.9%]), but increased between December-2021 and December-2022 among high-risk drinkers from less advantaged social grades (from 15.3% [95%CI 12.1–19.3] to 29.7% [20.1–44.1]). The only change in support use was an increase in smokers using paid support, specifically e-cigarettes (from 28.1% [23.7–33.3] to 38.2% [33.0–44.4]). Among those visiting their GP, the proportion who received an offer of support was similar over time among smokers (27.0% [25.7–28.2]) and high-risk drinkers (1.4% [1.1–1.6%]).

Conclusions

There is limited evidence that the 2021/22 cost-of-living crisis affected the nature of attempts to stop smoking and reduce alcohol consumption, or receipt of GP offer of support. It is encouraging that use of evidence-based support has not declined and that use of e-cigarettes in quit attempts has increased. However, cost is increasingly motivating alcohol reduction attempts among less advantaged drinkers, and rates of GPs offering support, especially for alcohol reduction, remain very low.
Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier
Authors: Suter Corinne , Colakovic Minela , Bieri Jan , Gultom Mitra , Dijkman Ronald , Ros Carlos
Published: May 2023

Parvovirus B19 (B19V) is transmitted primarily via the respiratory route, however, the mechanism involved remains unknown. B19V targets a restricted receptor expressed in erythroid progenitor cells in the bone marrow. However, B19V shifts the receptor under acidic conditions and targets the widely expressed globoside. The pH-dependent interaction with globoside may allow virus entry through the naturally acidic nasal mucosa. To test this hypothesis, MDCK II cells and well-differentiated human airway epithelial cell (hAEC) cultures were grown on porous membranes and used as models to study the interaction of B19V with the epithelial barrier. Globoside expression was detected in polarized MDCK II cells and the ciliated cell population of well-differentiated hAEC cultures. Under the acidic conditions of the nasal mucosa, virus attachment and transcytosis occurred without productive infection. Neither virus attachment nor transcytosis was observed under neutral pH conditions or in globoside knockout cells, demonstrating the concerted role of globoside and acidic pH in the transcellular transport of B19V. Globoside-dependent virus uptake involved VP2 and occurred by a clathrin-independent pathway that is cholesterol and dynamin-dependent. This study provides mechanistic insight into the transmission of B19V through the respiratory route and reveals novel vulnerability factors of the epithelial barrier to viruses.
Global citizenship education as a living ethical philosophy for social justice
Authors: Bosio Emiliano , Waghid Yusef
Published: May 2023

Envisioning a global citizenship education (GCE) that critically engages with neo-liberalism could be considered as being ‘feasibly utopian’. Yet, one of the core challenges facing GCE is that the market has been given too dominant position by the hegemony of neo-liberal doctrines, which has caused a growing number of schools and universities to approach curricular matters guided by concepts of international leadership, focusing on introducing innovation to curricula to satisfy international standards, participate in the global market and enter partnerships with industry and commerce. Given the ‘dominance’ of neo-liberal doctrines, it can be complex to pose alternative positions of GCE that are more oriented towards critical pedagogy. The articles in this issue explore philosophical, ethical and pedagogical visions of GCE focused on the relationship between world politics and social justice, women’s leadership and power, reflexive dialogic praxis and critical consciousness, de-colonialism and social responsibility. In different ways, each of the articles contributes to a re-imagined vision for GCE, through the important process of rethinking GCE for the common good.
Blank Canvas: Art School Creativity from Punk to New Wave, Simon Strange (2022)
Authors: Loydell Rupert
Published: May 2023

Review of: Blank Canvas: Art School Creativity from Punk to New Wave, Simon Strange (2022)

Bristol: Intellect, 297 pp.,

ISBN 978-1-78938-631-8, p/bk, £20.00
Rock Against Racism Live, 1977–1981, Syd Shelton (2022)
Authors: Loydell Rupert
Published: May 2023

Review of: Rock Against Racism Live, 1977–1981, Syd Shelton (2022)

Southport, NC: Café Royal Books, 36 pp.,

p/bk, £6.50

 

Syd Shelton: Rock Against Racism, 1976–1981, Carol Tulloch and Mark Sealy (eds) (2022)

Los Angeles, CA: Rare Bird Books, 187 pp.,

ISBN 978-1-64428-249-6, h/bk, £35.00
Otitis externa maligna. Experiencia a lo largo de 25 años en un hospital de tercer nivel
Authors: Álvarez-Álvarez María , Beniro-Orejas José Ignacio , Carranza-Calleja María Antonia , Cámara-Arnaz José Antonio , Viveros-Díez Patricia , Santos-Pérez Jaime
Published: May 2023

Introducción y objetivo: La otitis externa maligna (OEM) es una infección agresiva de los tejidos blandos del oído externo y estructuras circundantes, que puede diseminarse e involucrar la base del cráneo y la articulación temporomandibular (ATM). Afecta fundamentalmente a pacientes inmunodeprimidos mayores de 65 años.

El objetivo de este trabajo ha sido conocer las características de los pacientes diagnosticados de OEM en nuestro hospital durante los últimos años y establecer los criterios diagnóstico-terapéuticos de esta rara enfermedad.

Método: Se realizó un estudio descriptivo, observacional y retrospectivo, de los pacientes ingresados en el Hospital Clínico Universitario de Valladolid por OEM entre los años 1996 y 2021.

Resultados: En los últimos 25 años fueron ingresados por OEM nueve pacientes, 78% varones (7/9) y con una edad media de 76,8 años.

Todos los pacientes manifestaron precozmente la enfermedad con otalgia, otorrea y tejido de granulación en el conducto auditivo externo (CAE). Ninguno tuvo afectación de pares craneales, pero cuatro sufrieron invasión de la ATM y dos fallecieron.

Discusión y Conclusiones: Actualmente el diagnóstico de OEM se establece a partir de una variedad de hallazgos clínicos, de laboratorio y radiográficos. El tratamiento antibiótico depende de la severidad de la infección. Desde la aparición de los antibióticos antipseudomónicos, el tratamiento quirúrgico inicial de esta patología no está indicado, realizándose únicamente biopsia o desbridamiento para el diagnóstico diferencial con patología tumoral.

Conclusión: La OEM continúa siendo una enfermedad con grave morbilidad y potencialmente mortal, especialmente en pacientes ancianos y con otras comorbilidades.
Costilla cervical: tres casos para ilustrar su presentación clínica
Authors: González-Sosto Mariana , Benito-Orejas José Ignacio , Losada-Campa Juan , Álvarez-Álvarez María , Santos-Pérez Jaime , Sánchez-Ronco Marta Auxiliadora
Published: May 2023

Introducción y objetivo: La costilla cervical se manifiesta clínicamente como una tumoración de dureza pétrea en la región supraclavicular, que puede sugerir inicialmente malignidad. El objetivo de este trabajo, es ilustrar su presentación, para facilitar la sospecha clínica y el diagnóstico, ofreciendo al paciente un pronóstico benigno. Método: Se presentan tres casos clínicos diagnosticados de costilla cervical en el servicio de ORL de nuestro hospital. Discusión: Los datos de la anamnesis, la exploración clínica y una radiografía simple de tórax, deberían ser indicios suficientes, para diferenciar esta entidad de un proceso maligno. Conclusiones En el diagnóstico diferencial de una masa dura supraclavicular, debemos pensar en la posibilidad de una costilla cervical.
Hallazgos clínicos asociados a un resultado ecocardiográfico normal en recién nacidos hospitalizado en un centro a gran altitud
Authors: Vasquez Hoyos Pablo , Quintero Villamizar Angie Marcela , Tapias Devia Sayda Mercedes , Merchan Pinto Erika Fernanda , Quintero Buitrago Henry Jose , Galindo Lopez Paula Daniela
Published: May 2023

Introducción: Los defectos congénitos cardíacos se presentan entre 4 a 10 por cada 1000 nacidos vivos y representan cerca del 10 % de las muertes. En la actualidad son pocos los hallazgos clínicos que sugieren un ecocardiograma anormal poco lo que se recurre a pruebas de tamizaje como la pulsioximetría, pero existen dudas sobre su precisión en ciudades de gran altitud. Objetivo: Determinar la relación entre los hallazgos clínicos de recién nacidos hospitalizados en una unidad a gran altitud y sus hallazgos ecocardiográficos. Métodos: Estudio histórico trasversal. Pacientes menores de 28 días de vida a quienes se les realizó un ecocardiograma como parte del abordaje diagnóstico, entre mayo del 2017 a enero del 2020. Se compararon las variables clínicas y paraclínicas con la presencia o no de hallazgos anormales ecocardiográficos mediante análisis bivariado y multivariado por regresión logística. Resultados: Se incluyeron 849 pacientes con medianas de edad de 4 días y 36 semanas de edad gestacional. Cinco recién nacidos (0.6 %) tuvieron una cardiopatía con defectos críticos, 25.2 % presentaron defectos no críticos (74.9 % presentó ductus arterioso persistente mayor de 2mm, 13.2 % comunicación interauricular mayor de 5 mm y 11.7 % hipertensión pulmonar) y en el 74.4 % fue normal. Al realizar el modelo multivariado, tener ≤7 días de vida (OR 2.1 [IC-95 % 1.22-3.34]), FiO2 >35 % (OR 2.02 [IC-95 % 1.42-2.86]), soplo cardíaco (OR 3.34 [IC-95 % 2.01-5.57]), malformación asociada (OR 2.35 [IC-95 %1.54-3.58]), dificultades alimentación (OR 1.57 [IC-95% 1.07-2.31]) y radiografía anormal (OR 1.54 [IC-95 % 1.04-2.31]), se comportaron como factores asociados de forma independientes para la presencia de un ecocardiograma anormal. Conclusiones: Este estudio detecto algunos hallazgos asociados a la presencia de ecocardiogramas normales que podría ayudar a crear un modelo predictivo para pacientes a gran altitud para mejorar el rendimiento de las pruebas de tamizaje desarrolladas a nivel del mar.
Fibrosing Cholestatic Hepatitis Masquerading Acute Rejection in Hepatitis C Virus–Positive Donor Liver Graft
Authors: Awan Rehmat Ullah , Rashid Shazia , Nabeel Ambreen , Samant Hrishikesh
Published: May 2023

Fibrosing cholestatic hepatitis is a rare complication that manifests in patients receiving organ transplantation from seropositive (hepatitis C virus or hepatitis B virus) donors. We report a rare case of such a phenomenon in the immediate post-transplant period.
Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression
Authors: Nakanishi Takaaki , Akita Masayuki , Ichikawa Chihiro , Kaneda Kunihiko , Tamura Isamu , Kawata Yumiko , Takahashi Masayuki , Imai Yukihiro
Published: May 2023

A sebaceous carcinoma is rarely seen in extracutaneous sites. We present a 75-year-old man who was admitted with epigastralgia and melena. Endoscopic examination revealed an ulcer on the posterior wall of the gastric antrum, and distal gastrectomy was performed. Histopathological examination revealed thin to thick trabeculae of polygonal cells with scattered foci of foamy cells, whereas Sudan 3 staining showed lipid vacuoles. Immunohistochemistry was positive for both p40 and SALL4. After considering these findings, we suggest sebaceous differentiation as the diagnosis. To the best of our knowledge, this is the first case of gastric carcinoma with sebaceous differentiation.
FIELD EXPERIMENTAL STUDY ON EXTERNAL PRESTRESSING REINFORCEMENT OF A 420M PC CONTINUOUS BEAM BRIDGE
Authors: Sun Zhonglin , Sun Quansheng , Li Jianfei , Yang Shengqi
Published: May 2023

In this paper, the practical engineering of a 420 m PC continuous beam bridge is taken as the research object, and an external prestressing reinforcement method is proposed to reinforce the damaged and cracked girder. The paper is to study the structural performance of PC continuous beam bridge before and after reinforcement. The heavy vehicle loading test of reinforced PC continuous beam bridge was carried out. A total of three test spans were selected, and each test span selected seven deflection test section and a strain test section. The corresponding finite element model was established and verified by the test results. Finally, it was concluded in this study that the external prestressing reinforcement method has a good effect on improving the loading capacity and overall performance of damaged bridges.
A “Novembrada” – Florianópolis, 1979 e as falas de militares: discutindo a narração sobre um episódio da ditadura civil-militar no Brasil
Authors: Santos Ademir Valdir dos , Paiva Luiz Felipe Souza Barros de
Published: May 2023

A Novembrada aconteceu em Florianópolis, em 30 de novembro de 1979, envolvendo protestos relacionados à visita do Presidente General Figueiredo. O artigo objetiva analisar as falas de militares sobre a Novembrada. A metodologia utiliza a História Oral, com a realização de entrevistas com quatro oficiais. A narração histórica auxilia na problematização das memórias, trazendo luzes sobre um episódio significativo no declínio do poder ditatorial. Os resultados discutem as memórias que focalizam os conflitos entre o Presidente e sua comitiva e os militantes, destacando o protagonismo do movimento estudantil. As análises consideram a visita fracassada, em função da crise da economia e da homenagem ao Marechal Floriano Peixoto, consideradas como fatores motivadores das insurgências populares. Como exemplo de resistência popular e impedindo o intento de popularizar a imagem de Figueiredo e do regime ditatorial, a Novembrada é um dos marcos no processo histórico de redemocratização do Brasil.
Apropriações da pedagogia moderna na Escola Normal de São Paulo: convergências e divergências entre Silva Jardim e Camillo Passalacqua (1884 a 1887)
Authors: Silva Carolina Mostaro Neves da , Polachini Bruna Soares
Published: May 2023

Este artigo investiga as trajetórias de Silva Jardim (1860-1891) e Camillo Passalacqua (1858-1920), na Escola Normal de São Paulo, a fim de analisar e comparar suas concepções de educação e ensino. Foram consultadas atas da congregação, ofícios, relatórios e regulamentos da escola, jornais do período e as obras dos docentes: Reforma do Ensino de Língua Materna (1884), de Silva Jardim, e Pedagogia e Methodologia (1887) de Passalacqua. Procuramos analisar como esses sujeitos se apropriaram de elementos dos discursos pedagógicos contemporâneos, como os preceitos do ensino gradual, racional e intuitivo, articulando-os com perspectivas político-filosóficas e religiosas bastantes distintas. Essas diferenças se expressam em seus escritos, assim como nas aulas, e são visíveis, sobretudo, nos materiais adotados para o ensino por cada docente em sua cadeira.
GASTOS PÚBLICOS COM A PRODUÇÃO AMBULATORIAL PARA INCONTINÊNCIA URINÁRIA EM HOMENS NO BRASIL: DATASUS, 2010-2019
Authors: Nicolato Fernanda Vieira , Reis Marcio Fernandes dos , Keulen Maria do Socorro Lina van , Chaoubah Alfredo
Published: May 2023

Objetivo: analisar os gastos públicos com a produção ambulatorial para incontinência urinária em homens no Brasil e regiões, entre os anos 2010 a 2019. Método: Trata-se de um estudo observacional e descritivo, realizado para as regiões Norte, Nordeste, Sul, Sudeste e Centro-Oeste do país em um período de dez anos. Os dados foram obtidos no Sistema de Informações Ambulatorial do Sistema Único de Saúde e extraídos e processados pelo programa TABWIN versão 4.1.5. A seleção dos dados foi organizada pelo valor pago por procedimento na população masculina, na faixa etária maior de 20 anos e por regiões do Brasil. Resultado: No período estudado, o gasto público médio com a produção ambulatorial para incontinência urinária em homens foi de R$ 92.141,00 por ano, sendo constatado um aumento de 590% entre 2010 e 2019. A região Sul apresentou os maiores gastos por procedimento quando comparada à região Centro-Oeste. Os maiores gastos foram concentrados nas regiões mais desenvolvidas, sendo a região Sudeste com gasto total de R$ 570.792,87, seguida da região Sul com gasto total de R$ 192.115,73.  Os gastos com homens entre 60 e 69 anos foram significativamente maiores em relação às faixas etárias entre 20 e 49 anos e acima de 80 anos. Conclusão: Os resultados evidenciaram que há concentração do gasto ambulatorial com a incontinência urinária em homens nas regiões geográficas com melhor infraestrutura e associação com o envelhecimento populacional.
3D wood-based evaporator for highly efficient solar steam generation
Authors: Xie Meihua , Zhang Ping , Jin Yangbing , Wang Zhe , Jin Chunde
Published: May 2023

Interfacial solar-driven steam generation is one of the most promising techniques used to produce clean water. However, achieving rapid water evaporation using solar steam generation devices is challenging because of their two-dimensional (2D) planar structures and confined evaporation areas. The three-dimensional (3D) structural design of evaporation devices improves water evaporation rates, thereby enhancing solar-driven steam generation. This study developed a 3D wood-based evaporator through 3D structure shaping and the flexible treatment of wood that involved coating photothermal materials with tannic acid. Because of the ampliative evaporation area and outstanding absorption, the water evaporation rate of the prepared 3D wood-based evaporator was as high as 2.5 kg m−2 h−1, and the efficiency of energy transformation was up to 101 % under simulated 1-sun irradiation; the evaporation rate and efficiency of energy transformation were considerably higher than those of 2D planar wood evaporators. Furthermore, the effective seawater desalination performance and good durability of the 3D wood-based evaporator were demonstrated. This study provides different insights into the fabrication of high-efficiency wood-based solar steam generators with high prospects for application in seawater desalination.
Does Early Educational Tracking Contribute to Gender Gaps in Test Achievement? A Cross-Country Assessment
Authors: Lorenz Theresa , Schneebaum Alyssa
Published: May 2023

On average, boys score higher on math achievement tests and girls score higher in reading; these gaps increase between primary and secondary school. Using PISA, PIRLS, and TIMSS data, we investigate the role of early educational tracking (sorting students into different types of secondary schools at an early age) on gender gaps in test achievement in a cross-country difference-in-differences framework. We find strong evidence that early tracking increases gender differences in reading. For math test scores, we do not find consistent evidence that early tracking contributes to the gender gap.
Ecce Homo: John 19:5, a Portrait of Jesus and a Tangle of Stories
Authors: Wilson Andrew P.
Published: May 2023

In the context of the Bible, reception history is about the inter-play of text and context. It is also about the capacity of stories to continue to be told, the practice of ongoing interpretation and about creativity and meaning making, often in ways that challenge the text/context divide. In exploring this challenge, I ask how a roughly drawn picture of Jesus as Ecce Homo from John’s trial scene (John 19:5), a piece of devotional art from 1940s Europe, might demonstrate the capacity of texts—John 19:5 and others—to act across a range of (loosely connected) contexts. How might diverse narratives—artistic, historical, ideological, biographical—engage with thought on reception theory and trouble the distinction between text and context, so as to demonstrate the surprising expansiveness of texts and textuality? When viewed via this picture, the words on the pages of canonical text are revealed to be dynamic, travelling through the cultural and devotional history of varying locations, times and epochs. These words are in a state of flux, continually being re-written, embellished upon and otherwise shaped and changed. Following their trails in connection with this picture of Jesus, I explore the complex qualities of story and textuality. These qualities have parallel implications for John’s Gospel, as an ongoing and increasingly tangled story of Empire, irony and ambivalence, a story that continues to play out in multiple, messy and often conflicting ways. Ultimately, to gather a number of narratives and to bind them within the frames of this picture becomes a way of demonstrating the slipperiness and even arbitrariness of historical reception. It elucidates the competing interests of context, scholarship and tradition, not to mention the ever-widening scope of possibilities for biblical textuality.
miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
Authors: Huang Xin , Zhang Wen , Shen Xiumin , Ma Sai , Liu Lili
Published: May 2023

Ovarian cancer is one of the major gynaecological malignancies and a leading cause of cancer-related deaths worldwide. Dysregulation of miR-2053 has been reported in numerous types of cancer; however, its function in ovarian cancer remains largely unknown. In our study, the roles of miR-2053 during the development of ovarian cancer were investigated. miR-2053 expression was examined in ovarian cancer specimens and cells. Furthermore, the detailed functions and downstream targets of miR-2053 were identified. Briefly, the levels of miR-2053 were assessed in ovarian cancer tissues and paired non-cancerous samples, as well as in ovarian cancer cells using reverse transcription-quantitative polymerase chain reaction. The proliferation of cells was determined by cell counting kit-8 kit, and the levels of PCNA were also examined using immunostaining. Cell migration and invasion were evaluated using Transwell assay, and E-cad expression was assessed by immunostaining. In addition, cell apoptosis was determined by flow cytometry, and the expression of cleaved caspase-3 was examined using western blotting. The results revealed the downregulation of miR-2053 in ovarian cancer tissues and cells. Moreover, miR-2053 mimics suppressed the proliferation, migration, and invasion of ovarian cancer cells, while cell apoptosis was promoted. In addition, SOX4 was a putative downstream molecule of miR-2053 in ovarian cancer. Furthermore, SOX4 is involved in miR-2053-regulated growth and metastasis of ovarian cancer cells. In summary, miR-2053 and its novel target SOX4 could serve essential roles during tumour development of ovarian cancer, more importantly, miR-2053/SOX4 axis may be novel candidate for targeted therapy for patients with ovarian cancer.
Crystal structure of a polymorph of potassium picrate, C6H2KN3O7
Authors: Luo Xinyao , Chen Cuilian , Hu Zunjian , Wang Fei , Sun Shanhu , Suo Zhirong , Su Li
Published: May 2023

C6H2KN3O7, monoclinic, P21/m (no. 11), a = 4.1681(2) Å, b = 10.6704(6) Å, c = 10.2381(6) Å, β = 95.134(2)°, V = 453.52(4) Å3, Z = 2, R

gt
(F) = 0.0404, wR

ref
(F
2) = 0.0967, T = 295 K.
Latinate terminology in Modern Greek: An “intruder” or an “asset”?
Authors: Krimpas Panagiotis G.
Published: May 2023

This article discusses Latinate Modern Greek (MG) terminology in the light of language planning, language contact, transliteration, registers, and speakers’ attitudes. It starts by describing sociolinguistic aspects of MG with respect to borrowing and proceeds with case studies of Latinate MG terms and their Greek-based synonyms from various science, arts, social, and technical fields. Focusing on phonological, morphological, semantic, and terminological issues such as semantic intra- and inter-linguistic transparency and consistency in the light of the long-standing cultural ties between Greece and the West, an updated approach to the form and utility of MG Latinate terms is attempted, aiming at influencing eventual language planning in Greek-speaking areas.
Synthesis and thermal characterization of composites based on Epidian 601 with flame retardants compounds
Authors: Wnuczek Krystyna , Sowa Karolina , Podkościelna Beata , Klepka Tomasz
Published: May 2023

This study presents the preparation and flammability characteristics of polymeric composites based on the epoxy resin Epidian® 601. The triethylenetetramine (TETA) and commercial curing agents based on polyamines (IDA and PAC) were used as crosslinking compounds. Moreover, two flame retardant compounds were added to this composition, the commercial Fire Retardant (FR) and triphenyl phosphate (TP). The chemical structure of the composites and the course of curing processes were confirmed by the ATR/FT-IR (Attenuated Total Reflection–Fourier Transform Infrared) analysis. The influence of different amounts of FR or TP on the flammability and thermal resistance was discussed in detail. After the flammability test the samples were also studied to assess their thermal destruction. In addition, the composites were subjected to the swelling tests, solvent resistance, and microscopic observations. The DSC curves revealed that all materials were characterized by good thermal properties. All materials were temperature resistant up to 300 °C. Furthermore, the measurements of the hardness of the composite demonstrated that the material EP601 + TETA + 10 %FR is the hardest. The addition of FR and RP influenced the flammability of the composites increasing the thermal resistance. The ageing tests in methanol, acetone, hydrochloric acid, and potassium hydroxide were also carried out.
Perbaikan Hasil Segmentasi HSV Pada Citra Digital Menggunakan Metode Segmentasi RGB Grayscale
Authors: Hastawan Ahmad Fashiha , Septiana Risma , Windarto Yudi Eko
Published: May 2023

Segmentasi warna merupakan salah satu  metode segmentasi pada pengolahan citra digital yang digunakan untuk memisahkan objek dari background pada suatu citra digital. Proses segmentasi tersebut bekerja berdasarkan model warna. Dua model warna yang sering digunakan untuk segmentasi adalah HSV dan RGB. Permasalahan segmentasi warna terjadi ketika objek tersebut memiliki lebih dari dua warna dan adanya pencahayaan yang mempengaruhi kondisi objek. Dua kondisi tersebut akan menyulitkan proses pengambilan objek berdasarkan rentang warna. Penelitian ini mengajukan suatu metode untuk mengatasi masalah tersebut. Metode yang akan digunakan adalah segmentasi HSV dan disempurnakan dengan kombinasi RGB Grayscale. Hasil dari kedua proses segmentasi akan dikombinasikan untuk menentukan objek yang akan dipisahkan dari keseluruhan objek pada citra digital. Hasil akhir menunjukkan bahwa objek dapat dipisahkan secara sempurna, meskipun objek terganggu oleh permasalahan yang telah dijelaskan sebelumnya.

Kata Kunciâ€” Pengolahan citra, Segmentasi warna, Model warna,  HSV, RGB
Aplikasi Marketplace Jasa Reparasi Barang Elektronik Berbasis Android
Authors: Kusumastuti Asriana Dyah , Avianto Donny , Wibowo Adityo Permana
Published: May 2023

Pesatnya perkembangan di dunia teknologi informasi memberikan dampak terhadap cara berbisnis. Saat ini, banyak orang lebih menyukai berbelanja secara online dibandingkan harus datang secara fisik ke toko. Aplikasi marketplace berbasis android menjadi pasar digital dengan jumlah transaksi yang sangat besar setiap harinya. Namun kebanyakan aplikasi marketplace yang ada saat ini masih terbatas pada produk berupa barang. Padahal jika dilihat lebih dalam lagi, kebutuhan akan produk jasa seperti jasa reparasi barang elektronik juga memiliki porsi yang cukup tinggi. Beberapa penyedia jasa telah membuat aplikasi sendiri yang membuat para calon pengguna jasa harus memasang banyak aplikasi jika ingin menggunakan jasa dari penyedia jasa yang beragam. Oleh sebab itu pada penelitian kali ini akan dibahas pembuatan marketplace di bidang jasa berbasis android dengan nama ServiceIn. Aplikasi marketplace yang dibuat berfokus pada jasa reparasi elektronik sebagai salah satu jasa yang paling banyak dicari semua orang. Evaluasi menggunakan kuesioner juga dilakukan pada peneltian ini setelah tahapan pembuatan aplikasi selesai. Evaluasi bertujuan untuk melihat tanggapan calon pengguna aplikasi terhadap kemudahan yang ditawarkan aplikasi. Berdasarkan hasil evaluasi, 56% jawaban â€œsangat setujuâ€, dan 38% jawaban â€œsetujuâ€ membuktikan bahwa aplikasi yang dibuat mampu membantu seseorang untuk memenuhi kebutuhan akan jasa reparasi barang elektronik dengan cara yang lebih mudah.
Pengembangan Aplikasi Tes Untuk Evaluasi Capaian Belajar Siswa SMK
Authors: Ekarini Fitria , Priyanto Priyanto
Published: May 2023

Tujuan dari penelitian untuk: mengembangkan aplikasi tes untuk evaluasi capaian belajar siswa SMK, dan mengetahui besarnya kualitas aplikasi tes untuk evaluasi capaian belajar siswa SMK. Metode Research and Development (R&D) adalah metode yang digunakan dalam penelitian ini dan menggunakan 5 tahap metode waterfall, yaitu communication, planning, modeling, construction, dan deployment. Dari penelitian tersebut didapatkan hasil yaitu: aplikasi tes yang dikembangkan adalah aplikasi berbasis web dengan menggunakan framework Laravel, hasil pengujian analisis kualitas menunjukkan aplikasi tes telah memenuhi standar ISO/IEC 25010 dalam semua aspek, diantaranya: aspek functional suitability, fungsi dapat berjalan 100%; aspek reliability menghasilkan 99% pada kriteria session, hits dan pages; aspek performance efficiency, diperoleh rata-rata waktu respon 1,56 detik, dan PageSpeed Score 97% (pada grade A), YSlow Score 83% (pada grade B); aspek usability, diperoleh kategori sangat layak; aspek maintainability, menunjukan hasil 92.26 dengan kategori Highly Maintainable (dalam arti sangat mudah dirawat);  aspek security, pada tingkat kerentanan aplikasi terhadap serangan berada pada level 2 atau medium , aplikasi tes yang dikembangkan memiliki tingkat keamanan yang cukup baik; dan aspek portability, aplikasi berhasil dijalankan pada empat mobile dan  desktop browser yang berbeda.
Media E-Learning Bangun Ruang Sisi Datar: Kelayakan pada Pembelajaran Daring
Authors: Lutfi Muh Khaedir , Kusumastuti Fitri Anisa , Akib Irwan , Rohmawati Aeni
Published: May 2023

Media E-Learning Bangun Ruang Sisi Datar yang digunakan dalam penelitian ini dikembangkan melalui model ADDIE, yaitu Analyze, Design, Development, Implementation, dan Evaluation. Penelitian ini bertujuan untuk mengetahui kelayakan Media E-Learning yang diimplementasikan pada pembelajaran daring. Uji Ahli Media dilakukan oleh dua dosen yang mengajar media pembelajaran. Uji Ahli Materi dilakukan oleh dua dosen yang mengajar geometri. Uji pengguna siswa dilakukan dengan melihat respon siswa terhadap penggunaan Media E-Learning, sedangkan Uji Ahli Pengguna guru dilakukan dengan melihat respon guru saat menggunakan Media E-Learning. Data Uji Ahli Media dan Uji Ahli Materi dikumpulkan melalui lembar validasi, sedangkan data dari Uji Pengguna dikumpulkan melalui angket respon pengguna. Hasil penelitian menunjukkan bahwa persentase validasi dari Uji Ahli Media pada aspek Interface sebesar 77,08%, Kualitas Teknis sebesar 79,17%, Penyajian dan Tata bahasa sebesar 79,17%, serta rata-rata keseluruhan sebesar 78,47% dengan kategori layak. Uji Ahli Materi pada aspek Kelayakan Penyajian sebesar 84,38%, Proses Pembelajaran sebesar 87,50%, Penilaian sebesar 81,25%, serta rata-rata keseluruhan sebesar 84,38% dengan kategori sangat layak. Skor rata-rata respon pengguna siswa dan guru masing-masing sebesar 3,27 dan 3,33 dengan kategori layak. Oleh karena itu, Media E-Learning Materi Bangun Ruang Sisi Datar layak digunakan dalam pembelajaran daring.
Integrasi Technology Readiness dan Technology Acceptance Model untuk Analisis Kesiapan Pengguna Terhadap Penerimaan Aplikasi Parenting
Authors: Afiana Fiby Nur , Karomatunnisa Hanun , Ayuningtyas Sekar
Published: May 2023

Aplikasi Parenting, ditujukan untuk membantu orang tua milenial dalam menemukan dan menentukan minat dan potensi anak khususnya pada anak usia dini. Penerapan konsep LMS (Learning Management System) pada Aplikasi Parenting Pinggu Hompimpaa memiliki tantangan tersendiri, LMS yang berfokus pada pendidikan anak usia dini masih jarang ditemukan. LMS yang sering dimanfaatkan umumnya pada jenjang pendidikan dasar atau pendidikan formal. Sebelum dikenalkan lebih lanjut ke dalam pangsa pasar yang lebih luas, perlu diadakan pengukuran tingkat kesiapan user terhadap penerimaan user. TR dan TAM dikombinasikan menjadi sebuah metode TRAM (Technology Readiness and Acceptance model) dengan penambahan satu variabel yaitu Persepsi kenyamanan. Model ini meningkatkan cakupan model kesiapan dan penerimaan teknologi sebelumnya dalam hal penerapan dan kekuatan penjelas dengan cara mengukur adopsi teknologi dalam situasi di mana adopsi tidak diinstruksikan oleh tujuan organisasi. Hasil akhir yang diolah menggunakan SmartPLS 3 dengan 6 hipotesis meyatakan variabel TRAM dengan variabel Persepsi kenyamanan  memberikan respon yang positif terhadap niat dan penerimaan pengguna dalam menggunakan aplikasi parenting yang bertujuan untuk meningkatkan minat dan bakat anak.
Penanganan Imbalanced Dataset untuk Klasifikasi Komentar Program Kampus Merdeka Pada Aplikasi Twitter
Authors: Magnolia Cindy , Nurhopipah Ade , Kusuma Bagus Adhi
Published: May 2023

Imbalanced dataset merupakan hal yang sering ditemukan secara alami dalam proses penambangan data. Kondisi ini sangat mempengaruhi keakuratan klasifikasi data seperti yang terjadi dalam klasifikasi komentar program Kampus Merdeka yang peneliti lakukan. Penelitian ini akan fokus pada penanganan Imbalanced dataset untuk meningkatkan kinerja klasifikasi komentar yang berasal dari aplikasi Twitter. Data diklasifikasikan ke dalam empat kelas yaitu kelas 0 (untuk informasi), kelas 1 (untuk opini), kelas 2 (untuk pertanyaan), dan kelas 3 (untuk out of topic). Metode yang digunakan untuk balancing dataset adalah Undersampling, Oversampling menggunakan SMOTE dan ADASYN, serta Random Combination Sampling. Evaluasi performa dilakukan menggunakan algoritma Support Vector Machine (SVM) dengan perbandingan komposisi data training dan testing 80:20. Metode pembobotan data yang digunakan adalah Term Frequency-Inverse Document Frequency (TF-IDF) dengan nilai max_features 3000, 5000, dan 7000. Hasil pengujian awal menunjukan bahwa nilai akurasi dan F1-score pada Imbalanced dataset secara berurut-urut adalah 0,7 dan 0,7. Sedangkan metode penanganan Imbalanced dataset dapat meningkatkan nilai F1-score, kecuali pada penerapan metode Undersampling. Metode terbaik ditunjukan oleh penerapan ADASYN dengan nilai akurasi dan F1-score berurut-urut sebesar 0,9 dan 0,9. Penggunaan max_features pada TF-IDF juga mempengaruhi hasil performa klasifikasi, dengan max_features terbaik ditunjukan pada jumlah 5000.
Development of Southeast Asian Geographic Introduction Education Game for Elementary School
Authors: ‘Ammar Mohammad Faqih Eza , Priyawati Diah , Al Isyadi Fatah Yasin , Pamungkas Endang Wahyu
Published: May 2023

Pengenalan peta Asia Tenggara merupakan salah satu pokok bahasan Ilmu Pengetahuan Sosial di SD. Dengan metode pembelajaran manual konvensional, siswa mudah bosan dan menyulitkan siswa untuk tertarik dengan hal tersebut. Permainan edukasi dapat dijadikan alternatif terhadap metode pembelajaran konvensional untuk meningkatkan minat belajar siswa. Keuntungan dari permainan edukatif dibandingkan dengan metode pembelajaran tradisional adalah memiliki lebih banyak visualisasi dan interaktivitas. Pengembangan game edukasi pengenalan geografis Asia Tenggara yang disebut 'Eksplorasi ASEAN' dilakukan dengan menggunakan metode SDLC dari Royce dengan model waterfall. Permainan ini diharapkan mampu membantu siswa dalam belajar tentang geografi Asia Tenggara. Uji coba permainan dilakukan dengan purposive sampling di "SD Muhammadiyah 2 Surakarta" melibatkan tiga guru kelas enam dan 20 siswa kelas enam dengan kuesioner sebagai metode pengumpulan data. Berdasarkan pengujian Blackbox dapat disimpulkan bahwa game berjalan seperti yang diharapkan pada smartphone dan komputer pribadi. Pada penelitian ini, tes pada game dari validasi ahli material berada pada kategori 'Sangat Layak'. Adapun hasil tes SUS yang dilakukan oleh siswa, sistemnya masuk kategori 'Acceptable'. Hasil tes menyimpulkan bahwa permainan edukasi telah memenuhi persyaratan materi dan layak dijadikan sebagai bagian dari media pembelajaran.
Congenital hyperinsulinism and panhypopituitarism: a rare combination
Authors: Patel Foram , Darling Ginger , Torky Ahmed
Published: May 2023

Neonatal hypoglycemia is a serious condition that can have a major impact on the growing neonatal brain. The differential diagnosis of neonatal hypoglycemia is broad and includes hyperinsulinism as well as panhypopituitarism. The FOXA2 gene has been involved in the development of the pancreas as well as the pituitary gland. Six cases have been reported thus far with FOXA2 mutations presenting with variable degrees of hypopituitarism, and only two patients had permanent hyperinsulinism; other cases have been reported with microdeletions in 20p11, the location that encompasses FOXA2, and those patients presented with a wider phenotype. A full-term female infant presented with severe hypoglycemia. Critical sampling showed an insulin of 1 mIU/mL, suppressed beta-hydroxybutyric acids, and suppressed free fatty acids. Blood glucose responded to glucagon administration. Growth hormone (GH) stimulation test later showed undetectable GH in all samples, and cortisol failed to respond appropriately to stimulation. Gonadotropins were undetectable at 1 month of life, and MRI showed ectopic posterior pituitary, interrupted stalk, hypoplastic anterior pituitary, cavum septum pellucidum, and diminutive appearance of optic nerves. Whole-exome sequencing revealed a likely pathogenic de novo c.604 T>C, p.Tyr202His FOXA2 mutation. We expand the known phenotype on FOXA2 mutations and report a likely pathogenic, novel mutation associated with hyperinsulinism and panhypopituitarism.

Learning points

FOXA2 has been shown to play an important role in the neuroectodermal and endodermal development.

FOXA2 mutation may lead to the rare combination of hyperinsulinism and panhypopituitarism.

Patients reported so far all responded well to diazoxide. Dysmorphology may be subtle, and liver functions should be monitored.
Event-triggered leader-following formation control of general linear multi-agent systems with distributed infinite input time delays
Authors: Deng Ya , Zhu Wei
Published: May 2023

By employing event-triggered control technique, this paper investigates the leaderfollowing formation control problem of general linear multi-agent systems with distributed infinite input time delays. To decrease computing costs, a novel event-triggered formation protocol taking into consideration of the distributed infinite time delays between agents is put forward. Under the designed triggering function and triggering condition, a sufficient condition on leader-following formation is obtained, and then the Zeno-behavior of triggering time sequences is excluded for the concerned closed-loop system. The continuous update of controller for each agent is avoided. Finally, the correctness and the effectiveness of these theoretical results are demonstrated by two numerical examples.