bluuebunny/crossref_metadata_2025 huggingface dataset:
Enzymatic Synthesis of Sequence‐Defined Synthetic Nucleic Acid Polymers with Diverse Functional Groups
Authors: Kong Dehui , Lei Yi , Yeung Wayland , Hili Ryan
Published: September 2016

The development and in‐depth analysis of T4 DNA ligase‐catalyzed DNA templated oligonucleotide polymerization toward the generation of diversely functionalized nucleic acid polymers is described. The NNNNT codon set enables low codon bias, high fidelity, and high efficiency for the polymerization of ANNNN libraries comprising various functional groups. The robustness of the method was highlighted in the copolymerization of a 256‐membered ANNNN library comprising 16 sub‐libraries modified with different functional groups. This enabled the generation of diversely functionalized synthetic nucleic acid polymer libraries with 93.8 % fidelity. This process should find ready application in DNA nanotechnology, DNA computing, and in vitro evolution of functional nucleic acid polymers.
Oxygen‐Tolerant Electrodes with Platinum‐Loaded Covalent Triazine Frameworks for the Hydrogen Oxidation Reaction
Authors: Kamai Ryo , Kamiya Kazuhide , Hashimoto Kazuhito , Nakanishi Shuji
Published: September 2016

Reducing the use of platinum (Pt) on polymer electrolyte fuel cell anodes is critical for the widespread dissemination of these energy conversion systems. Although Pt usage can be minimized by the even dispersion of isolated Pt atoms, no atomically dispersed Pt catalysts that promote hydrogen oxidation at a rate required for practical fuel cells have been reported to date. Covalent triazine frameworks with atomically dispersed Pt atoms (0.29 wt %) are described and it is demonstrated that the material has a high electrocatalytic hydrogen oxidation activity without an overpotential. Importantly, when the loading amount was increased to 2.8 wt %, the electrocatalytic hydrogen oxidation activity of the resulting electrode was comparable to that of commercial carbon supported 20 wt % Pt catalysts, and the catalytic activity for oxygen reduction was markedly reduced. Thus, Pt‐modified covalent triazine frameworks selectively catalyze hydrogen oxidation, even in the presence of dissolved oxygen, which is critical for limiting cathode degradation during the start–stop cycles of fuel cells.
Phosphine‐Catalyzed Asymmetric Umpolung Addition of Trifluoromethyl Ketimines to Morita–Baylis–Hillman Carbonates
Authors: Chen Peng , Yue Zhenting , Zhang Junyou , Lv Xi , Wang Lei , Zhang Junliang
Published: September 2016

A novel phosphine‐catalyzed, highly enantioselective umpolung addition of trifluoromethyl ketimines to Morita–Baylis–Hillman carbonates was developed and it provides facile access to optically active trifluoromethyl amines with a chiral tertiary stereocenter under mild reaction conditions. The salient features of this reaction include general substrate scope, mild reaction conditions, good yields, high enantioselectivity, ease of scale‐up to gram scale, and further transformations of the products.
Synthesis of Linear (Z)‐α,β‐Unsaturated Esters by Catalytic Cross‐Metathesis. The Influence of Acetonitrile
Authors: Yu Elsie C. , Johnson Brett M. , Townsend Erik M. , Schrock Richard R. , Hoveyda Amir H.
Published: September 2016

Kinetically controlled catalytic cross‐metathesis reactions that generate (Z)‐α,β‐unsaturated esters selectively are disclosed. A key finding is that the presence of acetonitrile obviates the need for using excess amounts of a more valuable terminal alkene substrates. On the basis of X‐ray structure and spectroscopic investigations a rationale for the positive impact of acetonitrile is provided. Transformations leading to various E,Z‐dienoates are highly Z‐selective as well. Utility is highlighted by application to stereoselective synthesis of the C1–C12 fragment of biologically active natural product (−)‐laulimalide.
Controlled Ring‐Opening Polymerization of O‐Carboxyanhydrides Using a β‐Diiminate Zinc Catalyst
Authors: Wang Ruibo , Zhang Jiawei , Yin Qian , Xu Yunxiang , Cheng Jianjun , Tong Rong
Published: September 2016

Recently O‐carboxyanhydrides (OCAs) have emerged as a class of viable monomers which can undergo ring‐opening polymerization (ROP) to prepare poly(α‐hydroxyalkanoic acid) with functional groups that are typically difficult to achieve by ROP of lactones. Organocatalysts for the ROP of OCAs, such as dimethylaminopyridine (DMAP), may induce undesired epimerization of the α‐carbon atom in polyesters resulting in the loss of isotacticity. Herein, we report the use of (BDI‐IE)Zn(OCH(CH3)COOCH3) ((BDI)Zn‐1, (BDI‐IE)=2‐((2,6‐diethylphenyl)amino)‐4‐((2,6‐diisopropylphenyl)imino)‐2‐pentene), for the controlled ROP of various OCAs without epimerization. Both homopolymers and block copolymers with controlled molecular weights, narrow molecular weight distributions, and isotactic backbones can be readily synthesized. (BDI)Zn‐1 also enables controlled copolymerization of OCAs and lactide, facilitating the synthesis of block copolymers potentially useful for various biomedical applications. Preliminary mechanistic studies suggest that the monomer/dimer equilibrium of the zinc catalyst influences the ROP of OCAs, with the monomeric (BDI)Zn‐1 possessing superior catalytic activity for the initiation of ROP in comparison to the dimeric (BDI)Zn complex.
Synthesis of Angularly Substituted trans‐Fused Decalins through a Metallacycle‐Mediated Annulative Cross‐Coupling Cascade
Authors: Mizoguchi Haruki , Micalizio Glenn C.
Published: September 2016

A convergent coupling reaction is described that enables the stereoselective construction of angularly substituted trans‐fused decalins from acyclic precursors. The process builds on our alkoxide‐directed titanium‐mediated alkyne–alkyne coupling and employs a 1,7‐enyne coupling partner. Overall, the reaction is thought to proceed through initial formation of a tetrasusbstituted metallacyclopentadiene, stereoselective intramolecular [4+2] cycloaddition, elimination, isomerization, and regio‐ and stereoselective protonation. Distinct from our early studies directed at the synthesis of trans‐fused hydrindanes, the current annulative coupling reveals an important effect of TMSCl in controlling the final protonation—the event that establishes the stereochemistry of the ring fusion.
Hydrogen Peroxide Solvates of 2,4,6,8,10,12‐Hexanitro‐2,4,6,8,10,12‐hexaazaisowurtzitane
Authors: Bennion Jonathan C. , Chowdhury Nilanjana , Kampf Jeff W. , Matzger Adam J.
Published: September 2016

Two polymorphic hydrogen peroxide solvates of 2,4,6,8,10,12‐hexanitro‐2,4,6,8,10,12‐hexaazaisowurtzitane (CL‐20; wurtzitane is an alternative name to iceane) were obtained using hydrated α‐CL‐20 as a guide. These novel H2O2 solvates have high crystallographic densities (1.96 and 2.03 g cm−3, respectively), high predicted detonation velocities/pressures (with one solvate performing better than ϵ‐CL‐20), and a sensitivity similar to that of ϵ‐CL‐20. The use of hydrated materials as a guide will be important in the development of other energetic materials with hydrogen peroxide. These solvates represent an area of energetic materials that has yet to be explored.
Direct Synthesis of Functionalized High‐Molecular‐Weight Polyethylene by Copolymerization of Ethylene with Polar Monomers
Authors: Dai Shengyu , Chen Changle
Published: September 2016

The introduction of even a small amount of polar functional groups into polyolefins could excise great control over important material properties. As the most direct and economic strategy, the transition‐metal‐catalyzed copolymerization of olefins with polar, functionalized monomers represents one of the biggest challenges in this field. The presence of polar monomers usually dramatically reduces the catalytic activity and copolymer molecular weight (to the level of thousands or even hundreds Da), rendering the copolymerization process and the copolymer materials far from ideal for industrial applications. In this contribution, we demonstrate that these obstacles can be addressed through rational catalyst design. Copolymers with highly linear microstructures, high melting temperatures, and very high molecular weights (close to or above 1 000 000 Da) were generated. The direct synthesis of polar functionalized high‐molecular‐weight polyethylene was thus achieved.
A Study of Heterogeneous Catalysis by Nanoparticle‐Embedded Paper‐Spray Ionization Mass Spectrometry
Authors: Banerjee Shibdas , Basheer Chanbasha , Zare Richard N.
Published: September 2016

We have developed nanoparticle‐embedded paper‐spray mass spectrometry for studying three types of heterogeneously catalyzed reactions: 1) Palladium‐nanoparticle‐catalyzed Suzuki cross‐coupling reactions, 2) palladium‐ or silver‐nanoparticle‐catalyzed 4‐nitrophenol reduction, and 3) gold‐nanoparticle‐catalyzed glucose oxidation. These reactions were almost instantaneous on the nanocatalyst‐embedded paper, which subsequently transferred the transient intermediates and products to a mass spectrometer for their detection. This in situ method of capturing transient intermediates and products from heterogeneous catalysis is highly promising for investigating the mechanism of catalysis and rapidly screening catalytic activity under ambient conditions.
Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)‐Catalyzed Hydrogenation of 2,2′‐Bisquinoline Derivatives
Authors: Ma Wenpeng , Zhang Jianwei , Xu Cong , Chen Fei , He Yan‐Mei , Fan Qing‐Hua
Published: September 2016

An asymmetric hydrogenation of 2,2′‐bisquinoline and bisquinoxaline derivatives, catalyzed by chiral cationic ruthenium diamine complexes, was developed. A broad range of chiral endocyclic vicinal diamines were obtained in high yields with excellent diastereo‐ and enantioselectivity (up to 93:7 dl/meso and >99 % ee). These chiral diamines could be easily transformed into a new class of chiral N‐heterocyclic carbenes (NHCs), which are important but difficult to access.
Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective
Authors: Sautier Brice , Nising Carl F. , Wortmann Lars
Published: September 2016

Owing to their high occurrence rate across many human cancers and their lack of druggability so far, mutant forms of the signaling protein Ras are currently among the most attractive (and elusive) oncology targets. This strong appeal explains the sustained effort in the field, and the ensuing progress has rekindled optimism regarding the discovery of Ras inhibitors. In this Minireview, we discuss the most recent advances towards irreversible inhibitors, and highlight approaches to inhibitors of Ras–effector interactions that have been overshadowed by the current focus on direct Ras inhibition. At the same time, we provide a critical assessment from a medicinal chemistry perspective.
Investigation of pharmacophore and antipharmacophore features of certain dimethyltin(IV) complexes of flexible N‐protected amino acids and fluorinated β‐diketone/β‐diketones
Authors: Maheshwari Karuna , Srivastava Manish Kumar , Saxena Sanjiv , Jain Asha
Published: September 2016

A set of pentacoordinated dimethyltin(IV) complexes of flexible N‐protected amino acids and fluorinated β‐diketone/β‐diketones was screened for their antibacterial activity againstPseudomonas aeruginosa,Staphylococcus aureusandStreptomyces griseus. These pentacoordinated complexes of the type Me2SnAB (where: R = CH(CH3)C2H5, A1H; CH2CH(CH3)2, A2H; CH(CH3)2, A3H; CH2C6H5, A4H; and BH = R'C(O)CH2C(O)R″: R′ = C6H5, R″ = CF3, B1H; R′ = R″ = CH3, B2H; R′ = C6H5, R″ = CH3, B3H; R′ = R″ = C6H5, B4H) were generated by the reactions of dimethyltin(IV) dichloride with sodium salts of flexible N‐protected amino acids (ANa) and fluorinated β‐diketone/β‐diketones (BNa) in 1:1:1 molar ratio in refluxing dry benzene solution. Plausible structures of these complexes were elucidated on the basis of physicochemical and spectral studies.119Sn NMR spectral data revealed the presence of pentacoordinated tin centres in these dimethyltin(IV) complexes.
Fe3O4@TiO2@O2PO2(CH2)NHSO3H as a novel nanomagnetic catalyst: Application to the preparation of 2‐amino‐4,6‐diphenylnicotinonitriles via anomeric‐based oxidation
Authors: Zolfigol Mohammad Ali , Yarie Meysam
Published: September 2016

A new, green and reusable nanomagnetic heterogeneous catalyst, namely Fe3O4@TiO2@O2PO2(CH2)NHSO3H, was synthesized and fully characterized using suitable techniques such as infrared spectroscopy, X‐ray diffraction, scanning and transmission electron microscopies, thermogravimetry, vibrating sample magnetometry and energy‐dispersive X‐ray spectroscopy. The applicability of the constructed heterogeneous core–shell catalyst as a promoter was successfully explored for the synthesis of 2‐amino‐4,6‐diphenylnicotinonitrile derivatives upon the reaction of a good range of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate. The desired products were obtained with good to high yields in short reaction times under solvent‐free conditions. The suggested mechanism offers an anomeric‐based oxidation route to the products in the final step of the synthetic pathway.
Improved catalytic activity by catalase immobilization using γ‐cyclodextrin and electrospun PCL nanofibers
Authors: Canbolat M. Fatih , Savas Hasan Basri , Gultekin Fatih
Published: September 2016

Nanofibrous structures are promising for biocatalyst immobilization due to their large surface area which facilitates the enzyme attachment, stability, ease of separation, and fine porous structure. There is limited research available on the change in enzyme activity following interaction with cyclodextrin. In this study, catalase enzyme was immobilized into nanofibrous structures by various techniques, with and without γ‐CD addition, and the enzymatic activity of catalase was evaluated. In addition, catalase‐γ‐CD complex containing PEO polymer solution was electrospun in between PCL nanofibrous layers as a newly developed technique. The enzyme immobilized nanofibrous structures were characterized by SEM, XRD, and FT‐IR analysis methods. Among all the activity tests, best enzyme activity was recorded with catalase‐γ‐CD physical mixture encapsulated PCL nanofibrous layers. Moreover, the test results indicated that the use of cyclodextrin in immobilization process considerably improves the catalytic activity of the enzyme. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44404.
Usability of oxidized corn starch–gelatin blends for suppression and prevention of dust
Authors: Dang Xugang , Shan Zhihua , Chen Hui
Published: September 2016

Degraded gelatin (Gel) and oxidized corn starch (OCS) as renewable and abundant recyclable and biodegradable materials can be applied to dust mitigation, which has been investigated in this research. Blends of oxidized corn starch and gelatin (OCS‐Gel) were prepared by introducing the OCS into the Gel. Sodium carboxymethyl cellulose was used as a thickener and dispersant in the blends. The OCS‐Gel blends were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis (TGA). The results revealed that the blends have a uniform porous structure and can form stable Schiff's base structures. The TGA and DTGA thermograms indicated high thermal stability up to 325 °C. Moreover, the blend had good stability and compatibility by mixing with an electrolyte solution, and the biodegradability and water‐sorption measurements also revealed that the OCS‐Gel had excellent hygroscopicity and degradability. The results of contact angle measurements between OCS‐Gel solutions and dust showed that the blends have a satisfactory effect on dust wetting, and the results of light‐transmittance tests revealed that the blends had a good effect on dust‐removal ability. In addition, the dust particles can be evenly adsorbed on the surface of OCS‐Gel when they were evenly dispersed on the surface of the OCS‐Gel solution and can then form a film. The simulation experiment for flying dust in an enclosed area indoors indicated that the dust‐suppression degree for particulate matter less than 2.5 micrometers (PM2.5) and less than 10 micrometers (PM10) in size can reach 68.2% and 78.7%, respectively. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44437.
Validation of FLARE‐RA, a Self‐Administered Tool to Detect Recent or Current Rheumatoid Arthritis Flare
Authors: Fautrel Bruno , Morel Jacques , Berthelot Jean‐Marie , Constantin Arnaud , De Bandt Michel , Gaudin Philippe , Maillefert Jean‐Francis , Meyer Olivier , Pham Thao , Saraux Alain , Solau‐Gervais Elisabeth , Vittecoq Olivier , Wendling Daniel , Erpelding Marie‐Line , Guillemin Francis ,   on behalf of the STPR Group of the French Society of Rheumatology
Published: September 2016

Objective

To validate the measurement properties and the detection performance of the FLARE‐RA questionnaire in a longitudinal prospective study.

Methods

To validate the FLARE‐RA self‐administered questionnaire, we conducted a prospective trial in rheumatoid arthritis (RA) patients to document: 1) content and construct validity by factor analysis, convergent validity by Pearson's correlation with routine assessment of patient index data (Routine Assessment of Patient Index Data 3 [RAPID‐3] questionnaire), RA Impact of Disease (RAID) score, Disease Activity Score in 28 joints (DAS28), and Health Assessment Questionnaire (HAQ), 2) reliability (intraclass correlation coefficient [ICC] and Bland‐Altman plot), and 3) feasibility of use. Patients were examined and questionnaires were collected at baseline and 3 months, and every week in between for RAPID‐3.

Results

We recruited 138 patients from 13 centers: 81.9% women, mean age 57.4 years, mean DAS28 2.9, mean C‐reactive protein level 6.2 mg/liter, 84.4% rheumatoid factor positive, 78.0% anti–citrullinated protein antibody positive, and 78.8% with erosive disease. At baseline, the mean ± SD FLARE‐RA score was 2.3 ± 2.3. The content and construct validity of FLARE‐RA was good. A substantial floor effect, but no ceiling effect, was observed. Principal components analysis revealed 1 domain disentangled in 2 subdomains: physical and emotional. The FLARE‐RA total score was correlated with the DAS28 (r = 0.63, P < 0.001), RAID (r = 0.80, P < 0.001), RAPID‐3 (r = 0.77, P < 0.001), and HAQ (r = 0.53, P < 0.001). The ICC for reliability was 0.94 (95% confidence interval 0.92–0.96).

Conclusion

The FLARE‐RA self‐administered questionnaire represents a valid and valuable instrument to detect RA flare between visits to the physician.
Dual emission of Ce3+,Mn2+‐coactivated Ca3YNa(PO4)3F via energy transfer: a single component white/yellow‐emitting phosphor
Authors: Guan Anxiang , Yao Chunying , Wang Guofang , Fu Anjie , Zhou Liya , Meng Yingbin , Wang Qiuping
Published: September 2016

A series of Ce3+,Mn2+‐coactivated Ca3YNa(PO4)3F phosphors were synthesized via a traditional solid‐state reaction under a reductive atmosphere. X‐Ray powder diffraction was used to confirm that the crystal structure and diffraction peaks of Ce3+/Mn2+‐doped samples matched well with the standard data. A spectral overlap between the emission band of Ce3+ and the excitation band of Mn2+ suggested the occurrence of energy transfer from Ce3+ to Mn2+. With increasing Mn2+ content, the emission intensities and lifetime values of the Ce3+ emission for Ca3YNa(PO4)3F:Ce3+,Mn2+ phosphors linearly decrease, whereas the energy transfer efficiencies gradually increase to 89.35%. By adjusting the relative concentrations of Ce3+ and Mn2+, the emission hues are tuned from blue to white and eventually to yellow. These results suggest that Ca3YNa(PO4)3F:Ce3+,Mn2+ phosphors have promising application as white‐emitting phosphors for near‐ultraviolet light‐emitting diodes.
Meta-analysis of associating liver partition with portal vein ligation and portal vein occlusion for two-stage hepatectomy
Authors: Eshmuminov D , Raptis D A , Linecker M , Wirsching A , Lesurtel M , Clavien P-A
Published: September 2016

Background

Discussion is ongoing regarding whether associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) or portal vein occlusion is better in staged hepatectomy. The aim of this study was to compare available strategies using a two-stage approach in extended hepatectomy.

Methods

A literature search was performed in MEDLINE, Scopus, the Cochrane Library and Embase, and additional articles were identified by hand searching. Data from the international ALPPS registry were extracted. Clinical studies reporting volumetric changes, mortality, morbidity, feasibility of the second stage and tumour-free resection margins (R0) in two-stage hepatectomy were included.

Results

Ninety studies involving 4352 patients, including 320 from the ALPPS registry, met the inclusion criteria. Among these, nine studies (357 patients) reported on comparisons with other strategies. In the comparison of ALPPS versus portal vein embolization (PVE), ALPPS was associated with a greater increase in the future liver remnant (76 versus 37 per cent; P < 0·001) and more frequent completion of stage 2 (100 versus 77 per cent; P < 0·001). Compared with PVE, ALPPS had a trend towards higher morbidity (73 versus 59 per cent; P = 0·16) and mortality (14 versus 7 per cent; P = 0·19) after stage 2. In the non-comparative studies, complication rates were 39 per cent in the PVE group, 47 per cent in the portal vein ligation (PVL) group and 70 per cent in the ALPPS group. After stage 2, mortality rates were 5, 7 and 12 per cent respectively.

Conclusion

ALPPS is associated with greater future liver remnant hypertrophy and a higher rate of completion of stage 2, but this may be at the price of greater morbidity and mortality.
Validation of an enantioselective LC–MS/MS method to quantify enantiomers of (±)‐OTX015 in mice plasma: Lack of in vivo inversion of (−)‐OTX015 to its antipode
Authors: Balaji Narayanan , Chinnapattu Murugan , Dixit Abhishek , Sahu Promod , P S Suresh , Mullangi Ramesh
Published: September 2016

Abstract

A highly sensitive, specific and enantioselective assay has been validated for the quantitation of OTX015 enantiomers [(+)‐OTX015 and (−)‐OTX015] in mice plasma on LC–MS/MS‐electrospray ionization as per regulatory guidelines. Protein precipitation was used to extract (±)‐OTX015 enantiomers and internal standard (IS) from mice plasma. The active [(−)‐OTX015] and inactive [(+)‐OTX015] enantiomers were resolved on a Chiralpak‐IA column using an isocratic mobile phase (0.2% ammonia/acetonitrile 20 : 80, v/v) at a flow rate of 1.2 mL/min. The total run time was 6.0 min. (+)‐OTX015, (−)‐OTX015 and IS eluted at 3.34, 4.08 and 4.77 min, respectively. The MS/MS ion transitions monitored were m/z 492 → 383 for OTX015 and m/z 457 → 401 for IS. The standard curves for OTX015 enantiomers were linear (r2 > 0.998) in the concentration range 1.03–1030 ng/mL. The inter‐ and intraday precisions were in the range 2.20–13.3 and 8.03–12.1% and 3.80–14.4 and 8.97–13.6% for (+)‐OTX015 and (−)‐OTX015, respectively. Both the enantiomers were found to be stable in a battery of stability studies. This novel method has been applied to the study of stereoselective oral pharmacokinetics of (−)‐OTX015 and unequivocally demonstrated that (−)‐OTX015 does not undergo chiral inversion to its antipode in vivo in mice.
Publicly available school websites — caption or censor?
Authors: Masinter Michael R.
Published: September 2016

The Justice Department issued a Supplemental Advance Notice of Proposed Rulemaking on May 9. The notice postpones issuing regulations addressing website accessibility under Title II of the Americans with Disabilities Act.
Test and apply your FERPA knowledge in real‐life scenarios
Authors: Sutton Halley
Published: September 2016

PHOENIX — Understanding the requirements of the Family Educational Rights and Privacy Act can mean the difference between staying in federal compliance for your college or university and being hit with lofty fines.
Attraction versus Repulsion in Rhodium‐Catalyzed Asymmetric Hydrogenation
Authors: Gridnev Ilya D.
Published: September 2016

For several decades of intensive research it has been accepted that the physical sizes and shapes of substituents are the main stereoregulating factors in Rh‐catalyzed asymmetric hydrogenation. In this paper, it is argued on the basis of accumulated experimental and computational evidence that weak noncovalent attractive interactions between the substituents of the chiral ligand and the substrate strongly contribute to the process of stereoselection in Rh‐catalyzed asymmetric hydrogenation in the same fashion as that observed in organocatalytic reactions and in biological enzymatic processes.
A Nickel(II) Complex as a Homogeneous Electrocatalyst for Water Oxidation at Neutral pH: Dual Role of HPO42− in Catalysis
Authors: Wang Jia‐Wei , Zhang Xiang‐Qiong , Huang Hai‐Hua , Lu Tong‐Bu
Published: September 2016

A new mononuclear nickel complex, featuring two cis‐relative labile sites, is reported as a homogeneous electrocatalyst for water oxidation in a neutral phosphate buffer. The water oxidation catalysis can be initiated at a moderate overpotential of approximately 0.48 V. Mechanistic studies reveal that the oxidation of water by a two‐electron oxidized species of the nickel catalyst is feasible, with formation of a peroxide intermediate through intramolecular O−O coupling. Interestingly, it has been found that the buffer base (HPO42−) plays a dual role in the catalytic system: it acts as a proton acceptor to expedite proton‐coupled electron transfer (PCET) during catalysis, but it also suppresses the electrocatalysis through an anation process.
Highly Efficient Palladium‐Catalyzed Allylic Alkylation of Cyanoacetamides with Controllable and Chemoselective Mono‐ and Double Substitutions
Authors: Gao Pei‐Sen , Li Ning , Zhang Jin‐Lei , Zhu Zhuang‐Li , Gao Zi‐Wei , Sun Hua‐Ming , Zhang Wei‐Qiang , Xu Li‐Wen
Published: September 2016

It was found that catalytic allylation of various cyanoacetamides proceeded smoothly and efficiently in environmentally benign PEG‐400 (PEG=poly(ethylene glycol)) in the presence of Pd(OAc)2 and novel triazine‐derived multifunctional ligand L1, with which this reaction could afford the structurally diverse mono‐ and double allylated adducts in good to excellent yields as well as good chemo‐ and regioselectivity. In addition, this Pd/L1/PEG‐400 catalyst system could be recycled for five runs with good yield and high efficiency, which supported the notion that the triazine‐containing Schiff base based phosphine ligand could be a multifunctional and reusable ligand encapsulated in PEG‐400.
ChemInform Abstract: Two‐Dimensional Phosphorus Porous Polymorphs with Tunable Band Gaps.
Authors: Zhuo Zhiwen , Wu Xiaojun , Yang Jinlong
Published: September 2016

Topological modeling and first‐principles calculations reveal 21 new 2D phosphorus allotropes with porous structure which can be obtained by topologically assembling of selected P monomers, dimers, trimers, tetramers, and hexamers.
ChemInform Abstract: Ferroelectric InMnO3: Growth of Single Crystals, Structure and High‐Temperature Phase Transitions.
Authors: Bekheet Maged F. , Svoboda Ingrid , Liu Na , Bayarjargal Lkhamsuren , Irran Elisabeth , Dietz Christian , Stark Robert W. , Riedel Ralf , Gurlo Aleksander
Published: September 2016

Single crystals of InMnO3 are grown from equimolar mixtures of In2O3 and Mn2O3 in a PbF2 flux (Mo/Al2O3 substrates, 950 °C, 60 h).
ChemInform Abstract: Ion Mobility, Conductivity, Structure, and Phase Transitions in K0.7M0.3SbF4 Compounds with M: Rb, NH4.
Authors: Kavun V. Ya. , Gerasimenko A. V. , Uvarov N. F. , Polyantsev M. M. , Zemnukhova L. A.
Published: September 2016

The title compounds are obtained upon solvent evaporation of aqueous solutions containing a 0.5:0.5:1 molar mixture of KF, RbF, SbF3 or a 0.3:0.7:1 molar mixture of KF, NH4F, and SbF3, respectively.
ChemInform Abstract: Growth, Composition, Ferroelectric and Magnetic Properties of New Multiferroic Pb3.3Mn4.8Ni1.1Ti0.56 O15.3 Single Crystals.
Authors: Tomov V. , Rafailov P. M. , Luo Chih‐Wei
Published: September 2016

The title multiferroic single crystals are grown from PbO, NiO, MnO2, and TiO2 in a PbO/PbF2/B2O3 flux (air, Pt crucible, 1420 K, 2 d; crystallization upon cooling to 1170 K at a rate of 0.5 K/h).
ChemInform Abstract: Structural and Magnetic Properties of Double Perovskite Oxide Ba2CeSbO6.
Authors: Dutta Alo , Mukhopadhyay P. K. , Sinha T. P. , Das Dipankar , Shannigrahi Santiranjan
Published: September 2016

The title compound is prepared by calcination of a stoichiometric mixture of BaCO3, Sb2O5, and Ce2(CO3)3 in air (Al2O3 crucible, 1673 K, 15 h).
ChemInform Abstract: Efficient Room‐Temperature Cooling with Magnets.
Authors: Boeije M. F. J. , Roy P. , Guillou F. , Yibole H. , Miao X. F. , Caron L. , Banerjee D. , van Dijk N. H. , de Groot R. A. , Brueck E.
Published: September 2016

Polycrystalline MnFe0.95P0.582Si0.34B0.078 with an Fe/Mn ratio of ≈1 is used to provide experimental evidence for the origin of the giant entropy change found for materials exhibiting a magnetocaloric effect in the form of an electronic reconstruction caused by the competition between magnetism and bonding.
ChemInform Abstract: High Quality Magnetic Oxide Thin Films Prepared via Aqueous Solution Processing.
Authors: Page Catherine J. , et al.
Published: September 2016

Thin films of nanocrystalline ferrimagnetic CoFe2O4 (CFO) are obtained from aqueous solutions containing Fe(NO3)3 and Co(NO3)2 (1.5 M) under ultrapure conditions at pH <3 by spin coating on B‐doped p‐type Si(100) wafers followed by drying (200 °C) and annealing (1.
ChemInform Abstract: Brookite TiO2 Photocatalyzed Degradation of Phenol in Presence of Phosphate, Fluoride, Sulfate and Borate Anions.
Authors: Zhang Xiao , Xiong Xianqiang , Xu Yiming
Published: September 2016

Photocatalytic measurements are carried out with a 1 g/L suspension of brookite TiO2 in presence of PO43‐, F‐, B4O72‐, and SO42‐ as well as 0.43 mmol Ph‐OH (300 W Hg lamp with 3.3 mW/cm2) and 2,4‐dichlorophenol.
ChemInform Abstract: Bimetallic Ag—Cu Alloy Nanoparticles as a Highly Active Catalyst for the Enamination of 1,3‐Dicarbonyl Compounds.
Authors: Rout Lipeeka , Kumar Aniket , Dhaka Rajendra S. , Dash Priyabrat
Published: September 2016

The catalyst is recyclable and reusable at least 4 times.
ChemInform Abstract: The Synthesis of Pyrroles and Oxazoles Based on Gold α‐Imino Carbene Complexes.
Authors: Loy Nicole S. Y. , Choi Subin , Kim Sunggak , Park Cheol‐Min
Published: September 2016

Cationic gold complexes of α‐oximimino carbenes react with weak nucleophiles including enol ethers and nitriles to provide the highly efficient synthesis of pyrroles and oxazoles.
ChemInform Abstract: Iron(III)‐Catalyzed Carbonyl—Olefin Metathesis.
Authors: Ludwig Jacob R. , Zimmerman Paul M. , Gianino Joseph B. , Schindler Corinna S.
Published: September 2016

The direct carbon—carbon bond construction between carbonyl and olefin moieties relying on iron as an environmentally benign catalyst is established.
ChemInform Abstract: A Facile Approach to α,β‐Unsaturated Lactams by Ring‐Closing Metathesis.
Authors: Gondal Humaira Yasmeen , Buisson Didier
Published: September 2016

Five‐ to seven‐membered α,β‐unsaturated lactams are prepared using Grubbs II catalyst.
ChemInform Abstract: A Mild and Selective Protecting and Reversed Modification of Thiols.
Authors: Li Xiangmin , Li Hongxian , Yang Wei , Zhuang Jinchen , Li Hao , Wang Wei
Published: September 2016

A wide range of thiols are quickly protected under mild conditions using bromomaleimides.
ChemInform Abstract: Synthesis of 1,2,3‐Triazolylmethoxyphenyl[1,2,4]triazolo[1,2‐a]indazoletrione Derivatives by Combining Click and Multicomponent Reactions.
Authors: Zolfigol Mohammad Ali , Khazaei Ardeshir , Faal‐Rastegar Toktam , Mallakpour Shadpour , Khavasi Hamid Reza , Salehi Peyman , Fakharian Mahsa
Published: September 2016

A one‐pot four‐component reaction between propargylated benzaldehydes, azides, dimedone and urazoles provides the title products in high yields.
ChemInform Abstract: Catalytic, Asymmetric Difluorination of Alkenes to Generate Difluoromethylated Stereocenters.
Authors: Banik Steven M. , Medley Jonathan William , Jacobsen Eric N.
Published: September 2016

A new method for the catalytic, asymmetric, migratory geminal difluorination of β‐substituted styrenes to access a variety of products bearing difluoromethylated tertiary or quaternary stereocenters is reported.
ChemInform Abstract: Catalytic Difluorination of Olefins.
Authors: Molnar Istvan Gabor , Gilmour Ryan
Published: September 2016

An operationally simple catalytic vicinal difluorination of simple olefins is reported using inexpensive reagent and commercially available p‐iodotoluene as the catalyst.
ChemInform Abstract: Diastereoselective Radical Hydroacylation of Alkylidenemalonates with Aliphatic Aldehydes Initiated by Photolysis of Hypervalent Iodine(III) Reagents.
Authors: Selvakumar Sermadurai , Sakamoto Ryu , Maruoka Keiji
Published: September 2016

The mild, metal‐free reaction delivers chiral ketones in a highly diastereoselective manner.
ChemInform Abstract: A Multi‐Component Synthesis of Functionalized O,S‐Dialkyldithiocarbonates.
Authors: Patra Gopal C. , Pal Sutanuka , Bhunia Sankar C. , Hazra Nirmal K. , Pal Sudhir C.
Published: September 2016

Employing DABCO as catalyst, primary, secondary, and non‐allylic alcohols are effectively utilized in the synthesis of the title dithiocarbonates under mild reaction conditions.
ChemInform Abstract: Low‐Valent Cobalt‐Catalyzed C—H Allylation.
Authors: Cong Xuefeng , Zhai Shengxian , Zeng Xiaoming
Published: September 2016

An efficient 2‐pyridyl directed C—H allylation of arenes is developed using a Grignard reagent as base and a simple Co(II)‐salt as catalyst.
ChemInform Abstract: Difunctionalization of Alkenes Using 1‐Chloro‐1,2‐benziodoxol‐3‐(1H)‐one.
Authors: Egami Hiromichi , Yoneda Takahiro , Uku Minako , Ide Takafumi , Kawato Yuji , Hamashima Yoshitaka
Published: September 2016

Oxy‐, di‐ and azidochlorination, chlorothiocyanation and iodoesterification proceed in the presence of Togni reagent Bio‐Cl (XVII) in a site‐selective manner.
ChemInform Abstract: New Benzimidazolium‐Based Chiral Ionic Liquids: Synthesis and Application in Enantioselective Sodium Borohydride Reductions in Water.
Authors: Singh Avtar , Chopra Harish Kumar
Published: September 2016

New chiral ionic liquids with good thermal stability and fluorescence activity are synthesized and employed in enantioselective sodium borohydride reductions of prochiral ketones to optically active alcohols.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Synthesis of Aryl Formates under Mild Conditions.
Authors: Jiang Li‐Bing , Li Rui , Li Hao‐Peng , Qi Xinxin , Wu Xiao‐Feng
Published: September 2016

The reaction tolerates a broad range of functional groups.
ChemInform Abstract: Hofmann Rearrangement of Carboxamides Mediated by N‐Bromoacetamide.
Authors: Jevtic Ivana I. , Dosen‐Micovic Ljiljana , Ivanovic Evica R. , Ivanovic Milovan D.
Published: September 2016

The title reaction is successfully applied to aliphatic and aromatic amides, including diamides.
ChemInform Abstract: Tertiary Amine‐Catalyzed and Direct Synthesis of α‐Chloroalkanesulfonylhydrazines from Azodicarboxylates and Sulfonyl Chlorides.
Authors: Zhou Bingnan , Xu Jiaxi
Published: September 2016

The new strategy offers access to the title products under mild reaction conditions.
ChemInform Abstract: Iron‐Catalyzed One‐Pot N‐Aroylation of NH‐Sulfoximines with Methylarenes Through Benzylic C—H Bond Oxidation.
Authors: Muneeswara Madithedu , Kotha Surya Srinivas , Sekar Govindasamy
Published: September 2016

The efficient title reaction tolerates a broad range of functional groups.
ChemInform Abstract: Magnesium Catalysis for the Hydroboration of Carbodiimides.
Authors: Weetman Catherine , Hill Michael S. , Mahon Mary F.
Published: September 2016

The complex MAC is found to be an effective precatalyst for the title reaction under mild conditions.
ChemInform Abstract: Asymmetric Organocatalytic Assembly of Oxindoles Fused with Spiro‐3,4‐dihydropyrans with Three Contiguous Stereocenters Consisting of Vicinal Quaternary Centers.
Authors: Vishwanath Manjunatha , Vinayagam Poopathy , Gajulapalli V Pratap Reddy , Kesavan Venkitasamy
Published: September 2016

An organocatalytic, inverse‐electron demand hetero‐Diels—Alder reaction of isatylidene β,γ‐unsaturated α‐ketoesters with cyclic β‐oxoaldehydes is developed.
ChemInform Abstract: Sc(OTf)3‐Catalyzed Diastereoselective Formal [3 + 2] Cycloaddition Reactions of Alkynylcyclopropane Ketones with Electron‐Rich Aromatic Aldehydes to Yield 2,5‐trans‐Tetrahydrofurans.
Authors: Zhang Chi , Xu Muyun , Ren Jun , Wang Zhongwen
Published: September 2016

Furthermore, the cycloadducts can be converted to polycyclic products such as (XII).
ChemInform Abstract: A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization.
Authors: Kawamata Yu , Hashimoto Takuya , Maruoka Keiji
Published: September 2016

The first transformation of β,γ‐unsaturated carboxylic acids to γ‐butenolides according to the title reaction is elaborated.
ChemInform Abstract: Copper(I)‐Catalyzed Sulfonylation of (2‐Alkynylaryl)boronic Acids with DABSO
Authors: Mao Runyu , Zheng Danqing , Xia Hongguang , Wu Jie
Published: September 2016

affording benzothiophene 1,1‐dioxides
ChemInform Abstract: Cu0‐Promoted Cyclization of Unsaturated α‐Halogeno Amides to Give β‐ and γ‐Lactams.
Authors: Clark Andrew J. , Duckmanton Jonathan N. , Felluga Fulvia , Gennaro Armando , Ghelfi Franco , Hardiman Jack R. D. , Isse Abdirisak A. , Manferdini Claudia , Spinelli Domenico
Published: September 2016

Generally, pyrrolidinones are obtained as products whereas in case of substrate (VI) azetidinones are obtained.
ChemInform Abstract: Visible Light Initiated Hantzsch Synthesis of 2,5‐Diaryl‐Substituted Pyrroles at Ambient Conditions.
Authors: Lei Tao , Liu Wen‐Qiang , Li Jian , Huang Mao‐Yong , Yang Bing , Meng Qing‐Yuan , Chen Bin , Tung Chen‐Ho , Wu Li‐Zhu
Published: September 2016

The key intermediates in this reaction are alkyl radicals generated by single‐electron transfer from the photoexcited catalyst to α‐bromo ketones, which subsequently react with enamines to undergo the Hantzsch reaction rapidly at ambient conditions.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Carbene Insertion into C(sp3)—H Bonds.
Authors: Sole Daniel , Mariani Francesco , Bennasar M.‐Lluisa , Fernandez Israel
Published: September 2016

A regioselective Pd‐catalyzed cyclization of α‐diazoesters to N‐arylpyrrolidines is developed.
ChemInform Abstract: 3,4‐Dihydro‐2H‐pyrrole‐2‐carbonitriles: Useful Intermediates in the Synthesis of Fused Pyrroles and 2,2′‐Bipyrroles.
Authors: Nebe Marco M. , Kucukdisli Murat , Opatz Till
Published: September 2016

Diarylated cyanopyrrolines are subjected to the reaction with α‐bromo‐ω‐chloroalkanes and dichloroalkene (XI) under different conditions.
ChemInform Abstract: Access to Indole Derivatives from Diaryliodonium Salts and 2‐Alkynylanilines.
Authors: Li Pengfei , Weng Yunxiang , Xu Xianxiang , Cui Xiuling
Published: September 2016

The reaction of the title substrates is carried out under efficient, environmentally friendly conditions.
ChemInform Abstract: Catalytic Synthesis of 3‐Thioindoles Using Bunte Salts as Sulfur Sources under Metal‐Free Conditions.
Authors: Qi Hong , Zhang Tongxin , Wan Kefeng , Luo Meiming
Published: September 2016

The title protocol is advantageous with respect to the use of odorless and stable Bunte salts as sulfenylating agents and iodine as non metallic catalyst.
ChemInform Abstract: Enantioselective Carbene Cascade: An Effective Approach to Cyclopentadienes and Applications in Diels—Alder Reactions.
Authors: Wang Xiangbo , Zhou Yunfei , Qiu Lihua , Yao Ruwei , Zheng Yang , Zhang Cheng , Bao Xiaoguang , Xu Xinfang
Published: September 2016

An asymmetric carbene cascade reaction, which proceeds through a carbene/alkyne metathesis and a formal [3+2] cycloaddition and converts alkynyl‐tethered enol diazoacetates to chiral bicyclic cyclopentadienes, is presented.
ChemInform Abstract: Synthesis of 9H‐Pyrrolo[1,2‐a]indole and 3H‐Pyrrolizine Derivatives via a Phosphine‐Catalyzed Umpolung Addition/Intramolecular Wittig Reaction.
Authors: Saleh Nidal , Voituriez Arnaud
Published: September 2016

Optimized reaction conditions are developed for the title process allowing cyclization reactions of heteroaryl aldehydes (I) or (IV) with acetylene dicarboxylate (II) to form the title products in high yields.
ChemInform Abstract: Regioconvergent and Enantioselective Rhodium‐Catalyzed Hydroamination of Internal and Terminal Alkynes: A Highly Flexible Access to Chiral Pyrazoles.
Authors: Haydl Alexander M. , Hilpert Lukas J. , Breit Bernhard
Published: September 2016

The reaction has a broad substrate scope and tolerates multiple functional groups.
ChemInform Abstract: Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter.
Authors: Vila Carlos , Amr Fares Ibrahim , Blay Gonzalo , Munoz M. Carmen , Pedro Jose R.
Published: September 2016

An asymmetric one‐pot reaction between isatin‐derived ketimines and pyrazolones provides the title products in high yields and with very high enantioselectivities.
ChemInform Abstract: Stereoselective anti‐Markovnikov Geminal Diamination and Dioxygenation of Vinylarenes Mediated by the Bromonium Ion.
Authors: Balaji Pandur Venkatesan , Chandrasekaran Srinivasan
Published: September 2016

The geminal dioxygenation of styrenes with 1,2‐ and 1,3‐diols is achieved in the presence of NBS/AgOTf as oxidant to give dioxoheterocycles completely stereoselectively.
ChemInform Abstract: Regiodivergent Cross‐Dehydrogenative Coupling of Pyridines and Benzoxazoles: Discovery of Organic Halides as Regio‐Switching Oxidants.
Authors: Yamada Shuya , Murakami Kei , Itami Kenichiro
Published: September 2016

The use of organic halides as oxidants to achieve the cross‐dehydrogenative coupling reaction of two unfunctionalized heteroarenes (pyridines and benzoxazoles) with palladium catalyst is described.
ChemInform Abstract: DBU‐Mediated [3 + 2] Cycloaddition Reactions of Donor—Acceptor Cyclopropanes with Nitromethane: Efficient Strategy for the Construction of Isoxazole Skeletons.
Authors: Xue Shuwen , Liu Jiaming , Wang Cunde
Published: September 2016

In addition to nitromethane other nitro compounds are employed.
ChemInform Abstract: Visible Light Triggered, Catalyst Free Approach for the Synthesis of Thiazoles and Imidazo[2,1‐b]thiazoles in EtOH : H2O Green Medium.
Authors: Mishra Anu , Srivastava Madhulika , Rai Pratibha , Yadav Snehlata , Tripathi Bhartendu Pati , Singh Jaya , Singh Jagdamba
Published: September 2016

The title synthesis from phenacyl bromide and thioureas or 2‐amino thiazoles features catalyst free, no additional oxidants, short reaction time, and excellent yields.
ChemInform Abstract: Transition Metal‐Free Steric Controlled One‐Pot Synthesis of Highly Substituted N‐Amino 1,2,3‐Triazole Derivatives via Diazo Transfer Reaction from β‐Keto Esters.
Authors: Nagarajan Rajendran , Jayashankaran Jayadevan , Emmanuvel Lourdusamy
Published: September 2016

Diazo transfer to in situ generated hydrazones using imidazosulfonyl azide as reagent results in the formation of 1,2,3‐triazoles in good yields.
ChemInform Abstract: Synthesis of Novel Polycyclic Heterosystems Based on 5‐Nitro[1,2,5]thiadiazolo[3,4‐e]benzofuroxan.
Authors: Starosotnikov Aleksei M. , Bastrakov Maxim A. , Pavlov Alexander A. , Fedyanin Ivan V. , Dalinger Igor L. , Shevelev Svyatoslav A.
Published: September 2016

Complex polycyclic compounds with potential NO‐donor activity are prepared utilizing Diels—Alder and Michael reactions.
ChemInform Abstract: Synthesis of 4‐(Alkoxyamino)chroman‐2‐ones via 6‐exo‐trig Cyclization of Carbon‐Centered Radicals into Oxime Ethers.
Authors: Bejarano Carlos A. , Diaz John E. , Loaiza Alix E.
Published: September 2016

The synthesis of the title chromanones leads to reasonably good yields and diastereoselectivity, when precursors contain a secondary alkyl bromide.
ChemInform Abstract: Access to 4,6‐Diarylpicolinates via a Domino Reaction of Cyclic Sulfamidate Imines with Morita—Baylis—Hillman Acetates of Nitroolefins/Nitrodienes.
Authors: Majee Debashis , Biswas Soumen , Mobin Shaikh M. , Samanta Sampak
Published: September 2016

The title process is advantageous with regards to operational simplicity, high yields and good functional group tolerance.
ChemInform Abstract: Base‐Mediated Synthesis of Highly Functionalized 2‐Aminonicotinonitriles from α‐Keto Vinyl Azides and α,α‐Dicyanoalkenes.
Authors: Shu Ke , Shao Jiaan , Li Hong , Chen Binhui , Tang Pai , Liu Xingyu , Chen Wenteng , Yu Yongping
Published: September 2016

The possible mechanism of the title synthesis involves not only the formation of 2H‐azirine from the thermolysis of vinyl azide and vinylogous carbanion from dicyanoalkene, but also an intramolecular nucleophilic attack between the nitrogen of the aziridine and a cyano group followed by cyclization, ring‐opening, and intramolecular rearrangement.
ChemInform Abstract: Gold(I) Catalyzed Tandem Cyclization of Propargylic Esters to 4‐Acyloxy‐1,2‐dihydroquinolines.
Authors: Sun Yuan‐Ming , Gu Peng , Gao Yu‐Ning , Xu Qin , Shi Min
Published: September 2016

A facile method to synthesize 4‐acyloxy‐1,2‐dihydroquinolines is established through a gold(I)‐catalyzed tandem [3,3]‐rearrangement and intramolecular hydroamination of propargylic esters, giving the desired products in good yields under mild conditions.
ChemInform Abstract: Copper‐Catalyzed Intermolecular Amidation of 8‐Methylquinolines with N‐Fluoroarylsulfonimides via Csp3—H Activation.
Authors: Zhang Xiaolei , Wu Rui , Liu Wanyi , Qian Dang‐Wei , Yang Jinhui , Jiang Pengju , Zheng Qing‐Zhong
Published: September 2016

The reaction tolerates various functional groups and does not require an additional oxidant.
ChemInform Abstract: Gold(III)‐Mediated Cyclization of 2‐Hydrazinylquinolines
Authors: Schmidt Alexander , Baune Matthias , Hepp Alexander , Koesters Jutta , Mueller Jens
Published: September 2016

affording triazoloquinolinium cations
ChemInform Abstract: Pyridofuropyrrolo[1,2‐a]pyrimidines and Pyridofuropyrimido[1,2‐a]azepines: New Chemical Entities (NCE) with Anticonvulsive and Psychotropic Properties.
Authors: Sirakanyan Samvel N. , Geronikaki Athina , Spinelli Domenico , Paronikyan Ruzanna G. , Dzhagatspanyan Irina A. , Nazaryan Ivetta M. , Akopyan Asmik H. , Hovakimyan Anush A.
Published: September 2016

The title compounds are easily synthesized from furo[2,3‐b]pyridines using POCl3 as the reagent.
ChemInform Abstract: Catalyst and Solvent Free One‐Pot Microwave Synthesis of Fused Pyrimidine Diones and Triones.
Authors: Sontakke Madhuri M. , Dhonde Madhukar G. , Bhaskar Chandrakant S. , Berad Baliram N.
Published: September 2016

The title diones and triones are prepared by one‐pot three‐component condensation of barbituric acids, various aldehydes, and carbamides or thiocarbamides under mild reaction conditions.
ChemInform Abstract: Synthesis of Alkenylboronic Esters: An Alternative Route to Trisubstituted Homoallylic Alcohols.
Authors: Gehrke Yvonne , Berg Christina Annette , Vahabi Roza , Pietruszka Joerg
Published: September 2016

Bromoboration and subsequent reaction with optically active diol (II) provides 2‐bromo substituted alkenylboronic esters (III).
ChemInform Abstract: Palladium‐Catalyzed Oxidative Carbocyclization—Borylation of Enallenes to Cyclobutenes.
Authors: Qiu Youai , Yang Bin , Zhu Can , Baeckvall Jan‐E.
Published: September 2016

Efficient reaction conditions are developed for the Pd‐catalyzed oxidative carbocyclization‐borylation of enallenes to allow the selective formation of cyclobutenes.
ChemInform Abstract: The Drastic Effect of Cobalt and Chromium Catalysts in the Borylation of Arylzinc Reagents.
Authors: Komeyama Kimihiro , Kiguchi Shinnosuke , Takaki Ken
Published: September 2016

A drastic additive effect for increasing the reactivity of arylzinc reagents, enabling the borylation of unreactive arylzinc compounds to afford various arylboronic esters is reported.