bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study of Tolerance Level of Persons Learned from Madrassa and University in Khyber Pakhtunkhwa Pakistan
Authors: Adnan Muhammad
Published: March 2023

A Latin word Tolerantia is introduced in English language as Tolerance means Patience or endurance has increasingly caught the attention of researchers and scholars in the present times. This research aims at exploring the major reasons related to the difference of tolerance levels of students learned from Madrassa and University. Secondly it sorts out the core differences and address them equally to find a way for their resolution through casual comparative research design. Data were collected conveniently from 300 respondents having ages ranged from 24 to 30 years from both disciplines (Madrassa & University) through five point likert scale questionnaire comprising of 29 items. For checking the reliability of the scale, a pilot study was conducted and .674 Cronbach’s Alpha was found. Data were analyzed on independent sample t-test through SPSS. The study found a significant difference between the tolerance level of students learned from Madrassa and University. The tolerance level of students learned from Madrassa was very low.
Implementation of Ecotourism Program as an Effort to Develop Village Tourism Potential in Serdang Wetan, Tangerang: Community Service Activities
Authors: Yunia Dabella , Nistia Sari Titis , Desmawan Deris , Syaifudin Rizal , Setyadi Sugeng
Published: March 2023

This article discusses the implementation of ecotourism program as an effort to develop village tourism potential in Serdang Wetan, Tangerang, through community service activities. The purpose of this article is to describe the process of community service activities carried out to enhance the skills and understanding of the village community and tourism developers in developing sustainable ecotourism that has positive impact on the surrounding environment. The methods used are through training, mentoring, and tourism promotion. The results of this community service activity are increasing awareness of the village community in tourism management, increasing the number of visitors and revenue from tourism, and helping to preserve the culture and environment in the area. In conclusion, community service activities in Serdang Wetan Village Tangerang have the potential to become a model for tourism development in other areas, especially in rural areas that have untapped tourism potential
Relationship between carpal bone morphology and scaphoid fracture location
Authors: kun Tamer , Meydaneri Serta
Published: March 2023

Aim: Morphological variations in carpal bone may have an effect on wrist pathologies. In this study, we examined the relationship between carpal bone morphologies and scaphoid fractures. Materials and Methods: Patients with a prominent scaphoid fracture on posteroanterior and ulnar deviation X-ray were included in the study. Morphological types of lunate, hamate, capitate, presence of capitate-fourth metacarpal joint and scaphoid fracture location were documented retrospectively. A total of 68 patients, 65 (95.6%) male and 3 (4.4%) female, were included in the study.
Results: Considering the scaphoid fracture types, 40 (58.8%) patients had waist fractures and 28 (41.2%) patients had proximal pole fractures. The association of fracture type and morphology of carpal bones was examined.
Conclusion: In our study, we found that lunate, capitate, hamatum morphology and ulnar variance, fourth metacarpal articulation had no effect on the scaphoid fracture pattern.
An evaluation of rapid antigen tests diagnostic performance in the detection of SARS-CoV-2 infection
Authors: Bayram G , lbudak Harun , Bozok Taylan , Aslan G
Published: March 2023

Aim: The study aimed simultaneously compare the diagnostic performance of the rapid antigen test (CoVard COVID-19 Rapid Antigen Test Kit, Turkey) and the RT-PCR test used in the detection of SARS-CoV-2 infection.
Materials and Methods: In this study, the results of rapid antigen tests and RT-PCR tests applied simultaneously to the diagnosis of SARS-CoV-2 infection on nasopharyngeal swab specimens taken from patients applying to the …… University Hospital Emergency Unit with various symptoms were retrospectively analyzed. The study included 308 patients with or without respiratory tract infection symptoms who underwent COVID-19 rapid antigen and RT-PCR testing.
Results: It was observed that 157 (51.0%) of the patients had symptoms related to COVID-19. A total of 50 (16.2%; 95%CI: 12.0-20.5%) of the patients' rapid antigen test and 97 (31.5%; 95%CI: 26.3-37.0) of the patients' RT-PCR test were positive. The rapid antigen test for 41 (42.3%; 95%CI: 32.0-52.9) out of 97 specimens with a positive RT-PCR test was also positive. The rapid antigen test was positive in nine (18%; 95%CI: 8.6-28.6) specimens while the RT-PCR test was negative. The concordance between the rapid antigen test and the RT-PCR was intermediate (k=0.437, p<0.0005).
Conclusion: Compared to nucleic acid-based tests, rapid antigen tests are practical and fast, as well as not requiring experienced personnel and special laboratory infrastructure. It was concluded that the use of rapid antigen tests will help provide rapid triage in emergency services, especially during the times when cases with COVID-19 are on the rise.
The use of selective arterial calcium stimulation test in the diagnosis of the hyperinsulinemic hypoglycemia
Authors: nsal Yasemin , l zen , Cander Soner , Ate Co , Aydemir Ensar , nsal Oktay , Ersoy Canan , rk Erdin
Published: March 2023

We examined the patients with hyperinsulinemic hypoglycemia who were performed non-invasive imaging techniques with doubtful or failed results. We compared the performances of the Selective Arterial Calcium Stimulation Test (SACST) and non-invasive imaging techniques. Eight patients with hyperinsulinemic hypoglycemia, performed SACST after evaluating with imaging modalities were examined retrospectively. Three patients were diagnosed with Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS), 4 with insulinoma, and 1 with autoimmune hypoglycemia after SACST. While the concordance between the SACST and surgery-proven pathology for insulinoma was 50% (2/4), the accuracy in the localization of insulinoma was 25%. Although SACST does not have high concordance with surgery-proven pathology and accuracy in the localization of insulinoma, it may be preferred in the differential diagnosis of hyperinsulinemic hypoglycemia in medical centers where other imaging techniques are not available, or in cases where other imaging methods obtain suspicious/inadequate diagnosis.
Causes of hereditary metabolic diseases in patients presenting with developmental delay
Authors: anl merve
Published: March 2023

Objective: Developmental delay has many causes such as intrauterine infections, brain malformations, chromosomal anomalies, metabolic diseases. Between 0.8% and 15% of developmental delays are due to inherited metabolic diseases. Early diagnosis of these patients is very important in terms of the fact that some of them can be treated and also genetic counseling can be given to the family. In this study, it is aimed to emphasize the importance of reporting the clinical, biochemical and imaging characteristics, follow-up and treatment processes of the patients diagnosed with hereditary metabolic disease in patients with unexplained developmental delay/intellectual retardation, followed by the Metabolism 4 outpatient clinic of Başakşehir Çam and Sakura City Hospital.
Materials and Methods: This retrospective study was conducted on the data obtained from the medical files of 192 patients aged 0-18 years, who were followed up with developmental delay/intellectual retardation between May 2021 and May 2022 in the metabolism 4 outpatient clinic of our tertiary care center.
Results: The female/male ratio of the patients was 13/36, and the age range was between 3 months and 17 years. 34 patients were diagnosed with a hereditary metabolic disease and 15 patients with a non-metabolic genetic disease. There was consanguineous marriage in 23/32 of the patients with hereditary metabolic disease and 6/15 of the other patients. The most common Inherited metabolic disease groups are mitochondrial diseases, and lysosomal storage diseases.
Discussion: Patients can present at any age, and hereditary metabolic disease group has an important place in the etiology and has a great importance in terms of including many treatable diseases. For this reason, referral of patients who apply to outpatient clinics with developmental delay/intellectual retardation to metabolism outpatient clinics is of vital importance in terms of diagnosis, treatment, family screening and genetic counseling.
Knowledge Levels of Mothers with 0-3 Years-Old Children about Vitamin D and Breast Milk
Authors: Parlak Mehmet , z Erdo , e Osman , z Harun
Published: March 2023

Aim: This study seeks to evaluate the awareness and knowledge levels of mothers with children younger than three years old about breast milk and vitamin D.
Materials and Methods: A questionnaire containing 14 questions was administered to 405 women who applied to a district state hospital in Turkey. Analyses were conducted using the SPSS (Statistical Package for Social Sciences; SPSS Inc., Chicago, IL) 22.0 application.
Results: The knowledge level of the mothers whose education level is high school and above was significantly higher than that of the mothers whose education level is secondary school and below (p=0.005). There was a significant difference between the economic status of mothers in terms of knowledge score (p<0.001). The knowledge score of the mothers who used vitamin D in their last pregnancy was higher than those who did not (p=0.028). The knowledge score of the mothers who gave vitamin D to their last baby was significantly higher than those who did not (p=0.019). There was a significant difference regarding the knowledge score according to the last baby's first six months of nutritional status (p<0.001) and the number of taking the baby out for vitamin D (p<0.001).
Conclusion: It is necessary to inform mothers, fathers, and family elders about breast milk and vitamin D starting from pregnancy. Family physicians, health workers, obstetricians, and pediatricians should constantly emphasize the importance of breast milk and vitamin D supplementation. Breast milk and vitamin D training should be organized regularly for health personnel. Pregnant classes and pregnancy school programs in wellness centers and hospitals should be used more effectively. As far as possible, healthy pediatric outpatient clinics should be opened in all hospitals.
Investigation of Electrocardiogram and Inflammation Parameters in Patients with First Episode Mania
Authors: c Ya , Abu Sabri , Ayhan Sel , c Bulut , Tekin Atilla
Published: March 2023

Aim: This study examined inflammation markers and electrocardiogram data in patients with first-episode mania (FEM). It aimed to examine the inflammation processes in the early stages of the disease and the frontal QRS-T (fQRS-T) angle in bipolar disorder (BD).
Materials and Methods: After exclusion criteria, 53 FEM patients and 59 healthy controls (HC) were included in the study. Sociodemographic, electrocardiogram (ECG) and lab data of the participants were evaluated.
Results: Mean of age and gender distribution did not differ between the groups (p=.743, p=.294, respectively). The heart rate of the FEM group was significantly higher than the HC group (p<.001). fQRS-T was significantly wider in the FEM group than in healthy controls (p=.20). Albumin was significantly lower in the FEM group than in the HC group (p<.001). CRP and CAR values were significantly higher in the FEM group than in HC (p=.009 and p=.011, respectively). In the FEM group, HDL value was significantly lower than HC, while LDL value was significantly higher than HC (p=<.001 and p=.001, accordingly). MHR and AIP values were significantly greater in the FEM group than in HC (p=<.001 and p=.006, respectively). The fQRS-T angle in FEM patients was associated with MHR (r=.37).
Conclusion: This study is unique in evaluating inflammatory markers, fQRS-T angle, and heart rate in FEM patients. In this study, we found significantly higher inflammatory markers of MHR, CRP, and CAR in FEM patients in the control group. We found that these findings were consistent with the literature. Since the fQRS-T angle was wider in the FEM group, the cardiovascular risk may be increased in the early stages of BD disease.
Evaluation of factors predicting pregnancy by comparing successful IVF cycles with previous failed ones of the same patients in the same year
Authors: Erdogan Kadriye , er Nazl , zen Emine , Erol S , Dilbaz Serdar , lu nci , n Yaprak
Published: March 2023

Aim: In this study, we aimed to examine the factors predicting pregnancy by comparing successful in vitro fertilization/ intracytoplasmic sperm injection (IVF)/(ICSI) fresh cycles with previous failed ones of the same patients in the same year.
Materials and Methods: The study consisted of two groups, failed (n:283) and successful IVF fresh cycles (n:283) that applied one after another within the same year, thusly each woman acted under her own control. IVF treatment indications, antral follicle count, ovulation induction protocol type, initial and total gonadotropin dose, progesterone, and estradiol (E2) levels on the trigger day, the number of oocytes retrieved and mature oocytes, number of Grade 1, Grade 2, Grade 3 embryo, day of embryo transfer (ET), endometrial thickness on trigger and oocyte pick-up (OPU) day, embryo-fundus distance and beta-human chorionic gonadotropin (B-hCG) levels on the 10th day after the ET were measured. The same luteal phase support was administered in both groups.
Results: Totally 566 cycles and 283 women were included in the study. There was a significant difference in luteinizing hormone (LH) levels on OPU day and number of grade 1 ET between the two groups, LH levels on OPU day and number of grade 1 ET were higher in successful IVF fresh cycles group (p<0.05).
Conclusion: Low serum LH levels on OPU day was associated with decreased pregnancy results. Increased IVF success was observed in grade 1 ET cycles.
Impact of insufficient weight gain after GDM diagnosis on small for gestational age and adverse perinatal outcomes
Authors: Ak Mehmet , ahin Mefkure , bey Cevat , Madenda Yusuf , Demir Mustafa
Published: March 2023

Background: In the current study, we purposed to examine the role of insufficient weight gain after GDM diagnosis in small for gestational age (SGA) and other adverse perinatal outcomes.
Methods: This retrospective cohort study conducted in a referral center over a 5-year period from 2017 through 2022 and 260 pregnant women who met the inclusion criteria were classified as insufficient weight gain (n:68) or appropriate weight gain as a control group (n:192) based on the United States Institute of Medicine (IOM) recommendations for body mass index as calculated by gestational weight gain per week after a diagnosis of GDM.
Results: Maternal demographic characteristics and delivery outcomes were similar between groups. BMI at the first visit, BMI at GDM screening, and BMI at delivery were significantly higher in the appropriate gain group compared to the insufficient gain group. After adjusting for the variables, we observed that insufficient weight gain after a GDM diagnosis was not associated with SGA (adjusted odds ratio [aOR], 1.964; 95% confidence interval [CI], 0.306–12.590).In addition, we found that other variables such as the prematurity (aOR, 1.205; 95% CI, 0.335–4.320) and NICU admission rates (aOR, 2.361; 95% CI, 0.456–12.231) were not associated with insufficient weight gain after a GDM diagnosis.
Conclusion: Our results indicate that insufficient weight gain after a GDM diagnosis is not a risk factor for SGA, prematurity, and NICU admission rates.
Hepatoprotective effect of pycnogenol in gentamicin-induced liver injury in rats
Authors: Metin Tuba
Published: March 2023

Aim: The present study aimed to investigate the possible hepatoprotective effect pycnogenol (PYC) in gentamicin (GEN)-induced liver injury in rats.
Materials and Methods: The study consisted of four groups of seven rats; control, PYC (20 mg/kg for 8 days), GEN (80 mg/kg for 8 days) and GEN+PYC. At the end of the experiment, liver tissues of all groups were collected for histopathological and immunohistochemical (fibrillin-1, caspase-3, and betatrophin antibodies) evaluation.
Results: Histopathological analysis revealed that the GEN treated group had liver damage as a result of the GEN administration compared to the control group. Additionally, fibrillin-1, caspase-3, and betatrophin expression all increased in rat liver tissues. However, PYC pretreatment significantly reduced the expression of the aforementioned antibodies and mitigated liver damage.
Conclusion: The anti-apoptotic and antioxidant properties of PYC may help to preserve liver histoarchitecture against GEN-induced hepatotoxicity.
The relationship between balance and flu-like symptoms: a medical condition that needs attention
Authors: kaya Serhat
Published: March 2023

Objective: In general, while upper respiratory tract viruses cause flu-like complaints, balance problems associated with these viruses are often overlooked. It has been a long time since the first appearance of Covid-19, but unfortunately, there is still no fully effective treatment for this disease. Along with balance manifestations, especially several vestibular symptoms such as dizziness, vertigo, and tinnitus are described as common clinical manifestations in COVID-19. In our study, we investigated the effects of Covid-19 on the balance system with routine balance tests and we tried to localize a possible disorder in the balance system.
Materials and Methods: Volunteers were divided into two groups. The number of volunteers in each group was thirty. The first group consisted of SARS-CoV-2-positive patients and the second group consisted of healthy people. Spontaneous nystagmus determination, Romberg test, Fukuda stepping test (FST), head thrust test (HTT), head shake test (HST), finger-nose test, and tandem walking test were applied.
Results: The lateral fall in the Romberg test, rotation in the FST, and nystagmus in the HST are significant in Group 1 (p<0.001), (p<0.001), (p<0.03). The relationship between the fall side in the Romberg test and the direction of rotation in the FST were found to be significant in Group 1 (p<0.001). Similarly, the relationship between the direction of rotation in the FST and the nys-tagmus direction in the HST, and the direction of the saccadic correction in the HTT were found to be sig-nificant (p<0.026), (p<0.010).
Conclusion: In SARS-CoV-2 positive patients, the balance system, especially the peripheric vestibular system, may be affected even if the patients do not have obvious complaints about balance. Routine balance tests that can be performed quickly in the outpatient clinic can be used effectively for the evaluation of balance.
A DEFICIENCY OR DEVELOPMENTAL DEFECT IN PANETH CELLS MAY LEAD TO ACUTE APPENDICITIS IN CHILDREN
Authors: Harma Birsen , Tecellioglu Fahriye
Published: March 2023

Objective
The aim of this study was to investigate whether there were differences in the Paneth cells between children with acute appendicitis (AA) and those with normal appendix (NA), and to reveal the distribution of and morphological changes in Paneth cells in appendix inflammation.
Materials and Methods
The data of 63 patients who underwent appendectomy diagnosed with acute appendicitis between January 2021 and December 2022, including age, gender, operative diagnosis, and postoperative histopathological examination results, were analyzed retrospectively. To evaluate the distribution and changes of Paneth cells throughout AA and NA groups, samples with hematoxylin and eosin (H & E)-stained sections were obtained from the Department of Histopathology's archives. Selected blocks were stained with Masson-Trichrome. The number of Paneth cells and the degree of granular density in the appendicitis tissues were statistically evaluated and compared with the results of the control group.
Results
A total of 63 appendectomies were performed, including 31 incidental appendectomies and 32 performed for preoperative diagnosis of acute appendicitis. There were no statistically significant differences between the groups that underwent surgery for AA and the NA in terms of gender and age (p>0.05). It was observed that the number of Paneth cells and granule density decreased significantly in acute appendicitis (AA) group (p<0.05).
Conclusion
Reduction or developmental deficiency in Paneth cells, which results in the loss of protective secretion, may increase the appendix's susceptibility to bacterial infection by allowing organisms to adhere and move across the mucosa. Such enhancement of infection may contribute to the pathogenesis of appendicitis.
Seasonal Dynamics in Gross Biochemical Composition of Asiatic Hard Clam, Meretrix meretrix Collected from the West Coast of Cox's Bazar, Bangladesh
Authors: Khanam Maliha , Hossain Md , Mia Md , Yeasmine Selina , Hossain Md , Uddin Md
Published: March 2023

The study aimed to evaluate the seasonal dynamics ingross biochemical compositions of Asiatic hard clam (Meretrix meretrix) collectedmonthly from the west coast ofCox's Bazar, Bangladesh fromJuly2018 to June 2019. The proportion of crude protein, crude lipids, carbohydrates, ash, crude fiber and moisture contents of the clam varied from 10.81 to 15.56%, 0.45 to 3.99%, 0.26 to 5.88%, 0.88 to 2.85%, 0.26 to 1.96% and 72.63 to 82.70% respectively on wet weight basis. Biochemical analysis revealed remarkable temporal variations in the percentage of biochemical components of the species. Pearson’s product-moment correlation coefficient indicated that water quality parameters (temperature, salinity and pH) and biochemical compositions of M. meretrix had different levels of correlations among themselves.Protein and fiber contents were moderately positively correlated with pH (r = 0.515 and 0.495 respectively) but moisture content was moderately negatively correlated with pH (r = -0.484). Protein exhibited strongpositive correlation with ash content (r = 0.856) and strong negative correlation with carbohydrates (r = -0.800). Moderate positive correlation was found between protein and lipid (r = 0.596). Protein, lipid, ash and fiber contents had moderate negative correlations with moisture content (r = -0.542, -0.641, -0.503 and -0.423 respectively). Overall, the study revealedthat Asian hard clam is an excellent source of several nutrients and the information furnished could be useful to the fishery managers for harvesting and marketing of M. meretrix in a particular season of the year based on the consumers’ specifications.
Quinoa – A Functional Food Crop: Morphological Descriptors
Authors: Sarwar A , Khatun Most , Fakir Md
Published: March 2023

Quinoa (Chenopodium quinoa Willd.), one of the oldest cultivated plants of Andes, has gained worldwide attention for its ability to grow in various stressful conditions and also due to its various health-promoting characteristics i.e., easily digestibility with high amounts of protein, vitamin B, omega-3 fatty acids, and others. To study (in detail) on morphological descriptors of four quinoa genotypes, an experiment was conducted at the Field and Laboratory of Plant Systematics, Department of Crop Botany, Bangladesh Agricultural University during Rabi season (November 2020 to March 2021) following a Randomized Complete Block Design with three replications. A spacing of 25 cm x 10 cm was used. Weeding and irrigation operations were done twice at 20 and 40 days after sowing. Quinoa plants are characterized by the angular stem, red-green, leaf rhomboidal, green, panicle shape intermediate showing both shapes – glomerulate and amarantiform, panicle green at the flowering and became pink at the physiological maturity stages. Plant height and stem diameter were ranged between 60.17-65.65 cm and 4.22-4.58 mm, respectively. The percentage of red and red-green coloured stem, number of teeth leaf–1 and leaf area were significantly influenced by genotypes and ranged between 20.00-46.58%, 53.31-80.00%, 5.60-9.10 and 4.84-6.01 cm2, respectively. Pollen grains are monads, medium in size, 42.99-51.30 µm, polypantoporate, scabrate (microechinate), and exine thickness 2.08-2.40 µm. Panicle length and width, 1000-seed weight and seed yield varied between 31.16-37.23 cm, 3.66-4.37 cm, 3.14-3.43 g and 2.66-3.86 g plant–1, respectively. Among the genotypes, G2 was most productive in the environmental conditions of Mymensingh region. Qualitative morphological traits can be used as markers in the description and characterization of quinoa genotypes. The variation existing among the quinoa genotypes could prove useful in the breeding programs.
Characterization of wheat genotypes for terminal heat stress tolerance in Bangladesh
Authors: Tithi Anannya , Sagor G
Published: March 2023

This study was aimed to determine the types and levels of variability, heritability, genetic progress, relationships between yield and the features that contribute to it, and some key indicators of terminal heat stress tolerance. Twenty different wheat genotypes were planted in the fields over the course of six different treatments spaced 10 days interval following a Randomized Complete Block Design (RCBD) with three replications. A high degree of significant variation was observed for all the characters studied. Estimates of the genotypic coefficient of variation (GCV) and phenotypic coefficient of variation (PCV) revealed that the phenotypic coefficient of variation was higher than the genotypic coefficient of variation, which indicates a large effect of environment on the expression of the characters studied. The highest estimates of PCV and GCV were observed for grain yield/plant followed by the number of tillers/plant. Heritability estimates revealed that characters like pollen fertility and sterility exhibited the highest heritability followed by days to maturity. The genetic advance was higher for grains/plants followed by plant height. Grain yield showed significant and positive phenotypic and genotypic correlations with grains/plant and 100-grain weight. Phenotypic path analysis revealed a significant direct positive effect of 100-grain weight on grain yield. Principal component analysis (PCA) revealed that the first five components having greater than one Eigenvalue contributed to 83.41% variability. The heat stress tolerance indices revealed that Bijoy and BARI Gom-25 had the lowest tolerance index (TOL), stress susceptibility index (SSI) values and highest yield susceptibility index (YSI) values which show more tolerance and less susceptibility to terminal heat stress and produce moderate grain yield under terminal heat stress. Balaka and Shughat had the highest mean productivity (MP), geometric mean productivity (GMP), and stress tolerance index (STI) values and produce high yields under terminal heat stress conditions.
Secretome of Hypoxia-Preconditioned Mesenchymal Stem Cells Enhance Angiogenesis in Diabetic Rats with Peripheral Artery Disease
Authors: Sazli Brama , Lindarto Dharma , Hasan Refli , Putra Agung , Pranoto Agung , Sembiring Rosita , Ilyas Syafruddin , Syafril Santi
Published: March 2023

Background: Lower limb peripheral artery disease (PAD) is the main risk of diabetes mellitus which result to high mortality rate. Approximately, 50% of patients who receive several treatments have passed away or lost limbs at a year’s follow-up. Secretome of hypoxia mesenchymal stem cells (S-MSCs) contains several active soluble molecules from hypoxia MSCs (H-MSCs) that capable inducing anti-inflammatory and vascular regeneration in PAD. Objective: In this study, we investigated the therapeutic potential of S-MSCs in improving dynamic function and angiogenesis of PAD diabetic rats. Methods: The PAD was established by the incision from the groin to the inner thigh and distal ligation of femoral arteries in rats with diabetes. Rats were administered with 200 µL and 400 µL S-MSCs that successfully filtrated using tangential flow filtration (TFF) system based on various molecular weight cut-off categories intravenously. ELISA assay was used to analyze the cytokines and growth factors contained in S-MSCs. Tarlov score were examined at day 1, 3, 5, 7, 10 and 14. The rats were sacrificed at day 14 and muscle tissues were collected for immunohistochemistry (IHC) and gene expression analysis. Results: ELISA assay showed that S-MSCs provides abundant level of VEGF, PDGF, bFGF, IL-10 and TGFβ. In vivo administration of S-MSCs remarkably enhanced the Tarlov score. S-MSCs improved angiogenesis through enhancing VEGF gene expression and significantly increasing CD31 positive area in muscle tissue of PAD diabetic rats. Conclusion: Our findings suggest that S-MSCs could improves dynamic function and angiogenesis in PAD diabetic rats.
The Importance of Prediabetes Screening in the Prevention of Cardiovascular Disease
Authors: Cosic Vesna , Jakab Jelena , Pravecek Marijana , Miskic Blazenka
Published: March 2023

Background: Prediabetes is a disordered state of glucose metabolism defined by an elevated blood glucose level that is below the level required for the diagnosis of diabetes. Prediabetes is associated with an increased risk of cardiovascular disease. The onset and progression of macrovascular disease occur during the prediabetes phase. Early diagnosis and screening of prediabetes are essential steps to prevent diabetes and its associated complications. Objective: To assess the prevalence of prediabetes and undiagnosed diabetes in patients with cardiovascular disease according to the ADA criteria. Methods: This cross-sectional study included 2968 a high cardiovascular risk patients aged 40 to 75 years admitted to the Department of Internal Medicine. Sociodemographic variables and other relevant medical history information were collected by the researchers during the clinical interview. A fasting blood sample was obtained to determine HbA1c levels and other relevant laboratory findings. Results: Of the total number of participants, 1496 participants were not diagnosed with diabetes, 485 (32.4%) of them had HbA1c values indicating prediabetes and 158 (10.6%) of them had HbA1c values indicating new diagnosed diabetes. Up to one-third of those with undiagnosed prediabetes had already been diagnosed with cardiovascular complications. Conclusion: Routine screening of glycemic metabolism could be valuable in identifying high-risk individuals before a cardiovascular event occurs.
Enterococcus Species Isolated from Urine Cultures and Antibiotic Resistance Rates
Authors: Bahçeci İlkay , Yıldız Soner , Şahin Kazım
Published: March 2023

While enterococci are found as flora elements in many parts of the body, they have recently emerged as different infectious agents such as urinary tract infections, bacteremia, and meningitis. Increasing antibiotic resistance also poses additional challenges in treatment. In this study, it was aimed to determine the species identification and antibiotic resistance rates of enterococci isolated from the urinary tract. Enterococcus strains isolated from urine culture samples sent to the routine microbiology laboratory from various clinics of our hospital between 01.01.2020 and 31.12.2021 with the preliminary diagnosis of urinary tract infection were included in this study. Samples were cultivated on sheep blood agar and eosin methylene blue agar, and species determination and antibiogram evaluation were carried out in accordance with the recommendations of EUCAST (European Committee on Antimicrobial Susceptibility Testing-2020-2021) using conventional methods and automated identification device (VITEK 2 Compact-BioMerieux-France). All enterococci isolates (n=349) were susceptible to vancomycin, teicoplanin, tigecycline and linezolid. Of Enterococcus faecalis isolates (n=238), 32.8% were resistant to ciprofloxacin, 23.7% to high-level gentamicin, 33.2% to imipenem, 2.5% to nitrofurantoin, and 26.9% to streptomycin. Of the Enterococcus faecium isolates (n=111), 84.7% were resistant to ciprofloxacin, 58.6% to high-level gentamicin, 91% to imipenem, 31.5% to nitrofurantoin, and 83.8% to streptomycin. In conclusion, it is important to determine the resistance patterns of enterococcus strains, which are most frequently isolated as the causative agent of urinary tract infection, and also cause other clinical presentations such as wound infection or bacteremia, and to establish appropriate treatment protocols and to determine new antibiotic resistances.
A Conceptual Framework for Systematic Review of Studies in Interactive Technology of Education Sciences in Turkey
Authors: DİNÇEL Öznur , ÇETİN Reşat , BERKER Selda
Published: March 2023

In the new century, mobile devices and online tools have become increasingly important in the social lives of many individuals. In this context, it is important to access valuable information for life, understand information in a short time at once, and shorten the process of accessing meaningful information from a pile of data, especially if we are in the learning process. In this regard, this study aims to examine the research conducted on Interactive Web 2.0 tools, which have recently been included in many different areas of research in Turkey between 2014 and 2020. The research method is a systematic review, and the study uses the systematic method. Detailed information is provided on the structure of the systematic review, databases and keywords, study selection criteria, data extraction methods, data analysis methods, and the evaluation of potential biases. Based on an examination of the trends in studies conducted using the keywords "Interactive Technology", "Education", and "University Students" in national databases in Turkey (such as ULAKBİM and DergiPark) and the Google Scholar database, conclusions are drawn according to the criteria identified in the study objectives. The data obtained in the study is categorized by year, research topics, study groups/samples, and research results. It is expected that the results of this study will contribute to new research in the relevant literature.
ALGORITMO PARTICIPATIVO E FABRICAÇÃO DIGITAL: FERRAMENTA DIGITAL PARA ADEQUAÇÃO ARQUITETÔNICA
Authors: Backheuser Luiz Alberto Fresl , de Campos Paulo Eduardo Fonseca
Published: March 2023

RESUMOSe o movimento moderno defendeu uma produção impositiva, onde o arquiteto poderia definir de maneira autoritária o desenho das cidades e seus edifícios, a partir de meados do século XX suas práticas e teorias passam a ser duramente criticadas. Alternativas contextualizadoras e participativas foram valorizadas como respostas a um mundo cada vez mais complexo, plural e diversificado. A inadequação arquitetônica às comunidades e famílias dos grandes conjuntos residenciais modernista aparece com frequência em debates profissionais, acadêmicos e nas comunidades em questão. Assim, o processo passa a ser debatido, em detrimento do produto. Se temos que considerar mais variáveis, a maneira como se atinge o resultado ganha importância sobre o resultado em si, que passa a ser inesperado. Na mesma época, autores como William Mitchel, Nicholas Negroponte, Yona Friedman e Christopher Alexander, defendem a união de processos participativos e ferramentas computacionais. União essa que vem sendo debatida até hoje com autores como José Pinto Duarte e Branko Kolarevic, que trazem o conceito de customização em massa para a arquitetura e o urbanismo.  Assim, o presente trabalho pretende refletir sobre processos participativos viabilizados por ferramentas digitais, a partir de um experimento, um algoritmo associado a um sistema construtivo, que permite a personalização de uma arquitetura.  O experimento se apropriará de outra pesquisa que desde de 2015 vem procurando adaptar diferentes experiências internacionais de soluções construtivas baseadas em um método subtrativo de fabricação digital. Espera-se, assim, contribuir com as discussões tanto sobre a participação dos usuários quando sobre a apropriação de novas tecnologias.
HIGH-TECH HIGH-TOUCH APLICADA A UMA AULA SOBRE ESCALA DE TEMPERATURA EM KELVIN SUPORTADA COM METODOLOGIA ATIVA BASEADA EM PROBLEMAS E SIMULADOR DE GASES IDEAIS
Authors: Amorim Antonio Eduardo Assis
Published: March 2023

A pandemia trouxe um novo cenário de aprendizagem tendo como base as aulas remotas, gerando novas atitudes tanto dos alunos quanto dos professores, utilizando de forma intensa as tecnologias de informação e comunicação nas aulas remotas. Este novo processo gerou incertezas em ambas as partes. Por parte do docente, a escolha de uma metodologia de ensino que suprisse as deficiências em uma aula remota. Por parte do aluno, o distanciamento dos colegas e da sala de aula, a concentração na aula remota, a sua participação na aula remota e de organização para que houve uma conciliação das tarefas escolares com as atividades domicilares. Uma forma de superar as dificuldades foi empregar aplicativos ou simuladores que pudessem reproduzir o ambiente de laboratório de forma virtual. Com o retorno das aulas presenciais, todas estas novas experiências trouxeram um novo olhar do processo de aprendizagem, tanto para alunos quanto aos docentes, especialmente no uso destas tecnologias. Boa parte dos docentes acabaram dominando uma nova ferramenta e desenvolvendo um estilo próprio de ensino, desenvolvido nos ambientes virtuais e que agora podem ser aplicados no ensino presencial. Por dominar novos aplicativos, o docente se sente encorajado a colocar eles em prática, aliando as melhores tecnologias com a metodologia ativa, explorando outros saberes dos alunos, reforçando a conexão humana, usando e incentivando o uso de plataformas digitais para manter um outro canal de comunicação com os alunos. Tal processo de ensino está sendo conhecido como High-Tech High-Touch, ou seja, mesclando as melhores tecnologias digitais tocando de forma sutil a sensibilidade do aluno, gerando um novo olhar para atuar no mercado de trabalho. Este artigo trata em descrever as experiências do docente com os alunos dos cursos de Construção Naval e Sistemas Navais, do terceiro semestre, em especial, na disciplina de termodinâmica, quando se aborda o assunto sobre unidades de temperatura, combinando o uso de um simulador de gases ideais com a metodologia ativa baseada em problemas, fortalecendo a aprendizagem dos alunos. Os resultados são bastante interessantes. Se antes da pandemia, se falava da escala e apenas mostrava a sua relação com a escala de temperatura em graus Celsius, nos pós pandemia, se usa da abordagem High-Tech High Touch mostrando que se aborda de forma diferente o assunto, explorando várias questões e habilidades dos alunos. A aula se torna bastante interessante e atrativa para os alunos. Para o docente, que atua como mediador, pode explorar diversas habilidades dos alunos, tornando o conteúdo agradável e colaborativo para o aluno.
TÉCNICA ESTATÍSTICA (ANOVA) NA ANÁLISE DA RESISTÊNCIA À COMPRESSÃO AXIAL
Authors: Dos Reis Marielza Corrêa , Dos Reis Mariele Corrêa , Serra Sheyla Mara Baptista , Zampieron João Vicente
Published: March 2023

Os sistemas construtivos demandam quantidades significativas de recursos naturais, entretanto, estes já começam a apresentar problemas quanto à sua escassez. A incorporação de recursos renováveis, tais como os resíduos de carvão vegetal (RCV), em compósitos cimentícios tende a minimizar tal problema. O presente estudo teve por objetivo analisar a variabilidade da resistência à compressão de argamassas com substituição parcial da areia fina por RCV e analisar estatisticamente tais resultados pela análise de variância ANOVA. De acordo com os resultados de resistência à compressão e da ANOVA, as composições com 20% RCV apresentaram melhor desempenho, em torno de 28 MPa. Tal fato comprova que a gestão integrada de sistemas nas pesquisas científicas, instiga novas tecnologias que corroboram as exigências do mercado e do meio ambiente, atentando-se para à constância na qualidade e confiabilidade dos novos produtos e da minimização de impactos ambientes.
ENTRE DESCARTÁVEIS E REUTILIZÁVEIS: POLÍTICAS PÚBLICAS SOBRE POBREZA MENSTRUAL NO NORDESTE DO BRASIL E OBSERVAÇÃO DE TECNOLOGIAS SOCIAIS INTEGRADAS
Authors: De Melo Evelynne Hildegard Marques , Pinto Caroline de Menezes , Mendonça Adriana de Lima , Barboza Railson da Silva
Published: March 2023

Probreza menstrual é o termo dado ao contexto que envolve vários aspectos sociais ligados a higiene da pessoa que menstrua. Tabus e ausência de olhar político exacerbam o problema. Trata-se de uma questão social mundial inteiramente ligada a fisiologia e dependente de política para minimizar consequências em saúde pública envolvendo uma tecnologia que é o absorvente para fluxo menstrual como algo imprescindível. Para resoluções neste tema, no Brasil, as unidades federativas encontram-se ao nível de propostas legislativas e o Rio de Janeiro representa pioneirismo. Este trabalho tem o objetivo de destacar a importância das políticas públicas de estado sustentáveis, através da análise das proposições políticas entre os meios descartáveis e reutilizáveis na região nordeste do Brasil e apresentar tecnologia sociais que auxiliem nas soluções. Em todas as capitais da região nordeste há iniciativas legislativas para o combate à pobreza menstrual, contudo os esforços direcionados ao método reutilizável deve ser desencorajado pelas razões óbvias da dependência de infraestrutura básica essencial à higiene, para as quais o nordeste mantém  críticos índices.
Employee retention strategies and organizational citizenship behaviour: Does career development practices matters? Evidence from environmental agencies in Kenya
Authors: Chepkemoi Judith
Published: March 2023

The main aim of the study was to determine the moderating role of career development practices on the relationship between employee retention strategies and organizational citizenship behaviour (OCB). Theories of Social exchange and Job embeddedness guided the study. A sample of 274 from a population of 935 employees drawn from the three Environmental Agencies within North Rift Region Kenya was randomly selected. The primary data was collected using closed ended questionnaires. Findings from hierarchical regression results indicated that employee involvement and leadership had significant and positive effect on OCB. The study further established that career development practices significantly and positively moderate the relationships between employee involvement and OCB, Leadership and OCB. The study concludes that employee involvement and leadership have a significant and positive effect on OCB which is crucial in the development of both public and private sector organizations and for OCB to thrive, the management should be encouraged to put more emphasis on career development practices. The study recommends that organizations should understand and develop a holistic approach of implementing career development practices and overall employee retention strategies which include employee involvement and leadership which focus on changing the demands of employees for sustained OCB.
Occurrence of Aflatoxin M1 and Risk Assessment in Bovine Milk from the Amazon Region
Authors: Diogenes Luiz C. G. , Kluczkovski Ariane M. , Goes Abrames F. F. , Pinto Samir de C. B. , Araujo Claudio F. , Kluczkovski-Junior Augusto
Published: March 2023

Aflatoxins (AFL) are fungal metabolites that can contaminate animal feed, causing toxic effects after consumption. Among the AFL, there are reports of the occurrence of aflatoxin M1 (AFM1) in milk, so the objective of this work was to evaluate the AFM1 content in bovine milk samples produced in the State of Amazonas-Brazil. Of the analyzed samples (n=30), 20% were found to be contaminated with AFM1 in the range of 0.093-0.320 μg/kg (Limit of detection= 0.0625 μg/mL). No sample exceeded current Brazilian legislation, but all exceeded the maximum European regulatory limit of 0.05 μg/kg. Risk analysis estimated a daily intake of 5.357 x 10-7 mg/kg body weight/day for men and 6.257 x 10-7 mg/kg body weight/day for women. The MOE result did not indicate concern in public health aspects. On the other hand, the occurrence of AFM1 in the state of Amazonas was observed in an unprecedented way and need further investigation including other dairy products.
Does foreign direct investment affect poverty in BRICS?
Authors: Tsaurai Kunofiwa
Published: March 2023

This study examined the influence of foreign direct investment (FDI) on poverty alleviation in BRICS countries (Brazil, Russia, India, China, and South Africa) using panel methods of econometric estimation, namely pooled ordinary least squares (OLS), fixed effects and fully modified ordinary least squares (FMOLS). Data from 1989 to 2020 was used in this study. The majority of research on FDI-led poverty has ignored the omitted variable bias. Economic growth as a channel in the FDI–poverty nexus was also explored. The relationship between FDI and poverty has so far produced mixed results with no general consensus, hence triggering the undertaking of this study in the context of BRICS. Except for mortality rate, poverty alleviation triggered by FDI was achieved in BRICS (model 1 under fixed effects; model 2 under pooled ordinary least squares (OLS). Economic growth-led poverty reduction was observed across all the three panel methods. The interaction variable (FDI x economic growth) significantly enhanced poverty reduction in model 1 and model 3 across the three panel data methods employed. Similar results were observed in model 2 under the pooled OLS methodology. Policies geared at promoting FDI to reduce poverty should be implemented by BRICS authorities. Further research should explore the minimum threshold levels of FDI necessary to significantly reduce poverty in BRICS as such a study would be more useful and relevant for policymaking decisions relating to poverty reduction.
The Interconnection of Text-Melody in Selected Works of Newlove Kojo Annan’s Choral Writings
Authors: Addaquay Alfred Patrick
Published: March 2023

As much as scholars of music composition in Ghana identify the prerequisite for intellectual dialogue so far as analytical study is concerned, very little attention has been paid regarding melodic structures and their relationship to text in vocal music. Consequently, upon further study of the melodic and textual structure of the choral writings of Newlove Kojo Annan’s music, I consider it necessary for a discussion since the introduction of word-based phraseology which was crafted from this paper, and other stimulating practices such as the proper use of stressed and unstressed syllables, speech and song melody, and few others have been detected in the construction of the text-melody relationship. In summary, this article presents an analytical work revealed from both music scores and recordings (audio visual) of the selected works, which gives a panoramic view, and serve as a guide for advance study and research in music composition. From my frame of reference and vantage, few recommendations are made in the structure of the works. The study discusses three selected (at random) works of Newlove Kojo Annan.
Students’ Perceptions on Corrections
Authors: Selvi M.D.Thamarai , Saraya Dr. P.
Published: March 2023

The study's aim is to find what the students think about corrections. Students from SRM University in Amravati, Guntur District, Andhra Pradesh, took part in the study. 52 engineering students from diverse branches make up the sample size. The participants were given a questionnaire using a four-point Likert scale. The majority of students believe that instructor feedback is insufficient to help them to improve their writing, which is the study's problem statement. The objectives are to help the student write more effectively. Peer correction is the method used in this study. In this study, a Community Language Learning (CLL) approach was used. The results and findings demonstrated that the students' involvement improved both their writing abilities and motivation. The students may improve their involvement in class discussion based on the teaching and learning process by using the Community Language Learning (CLL) method, even though there were occasionally grammatical errors. The students were also comfortable writing in English, but after employing the Community Language Learning (CLL) technique, they gave positive feedback.