bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction
Authors: Mishra Riya
Published: February 2025

Objectives

Thus, the study was designed to assess the ability of ICA to ameliorate MTX-induced renal toxicity in rats and determine the pathogenetic pathways of oxidative stress, inflammation, and apoptosis.

Methods

Mtx renal toxicity was developed following an intraperitoneal administration of 20 mg/kg MTX. ICA was orally given at 100 mg/kg/day for two consecutive weeks. Experimental indicators included: biochemical renal function – BUN, SCr; and oxidative stress – SOD, GSH-Px, MDA. Other histological studies included immunohistochemical staining for Nrf2 and HO-1, QPCR of pro-inflammatory cytokines and biomarker of kidney injury, and TUNEL assay to assess the protective effects affiliated with ICA.

Results

In an animal model treated with MTX, renal damage was reflected by increased oxidative stress, inflammatory-borne cytokines, and apoptotic indices. ICA treatment ameliorated these effects to a great extent by reversing changes in antioxidant enzyme activities, suppressing lipid peroxidation and regulating the Nrf2/HO-1 pathway. This was evidenced by the decrease in pro-inflammatory and kidney injury genes in the ICA-treated groups but by significant histological ameliorations of kidney structure. TUNEL assay proved the decreased apoptotic index in kidney tissue.

Conclusions

These findings exhibited the therapeutic efficacy of ICA for attenuating renal injury from MTX and established that it mainly exerts its cytoprotective effects through the Nrf2/HO-1 pathway.
Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
Authors: Pergolini Daniele , Mohsen Mohamed , Tenore Gianluca , Palaia Gaspare , Magnifico Lorenzo , Del Vecchio Alessandro , Romeo Umberto
Published: February 2025

Objectives

The aim of this study is to evaluate the bone scintigraphy (BS) and positron emission tomography (PET) in the early diagnosis of medication-related osteonecrosis of the jaws (MRONJ) and their possible use in the identification of patients at risk for MRONJ.

Material and methods

Thirty-one patients treated with ONJ-related drugs and who had undergone BS or PET for the evaluation of bone lesions were included in the study. The jaws of each patient were divided into four areas. For each area, the presence of pathological tracer uptake was evaluated and related to the eventual MRONJ development. Sensitivity, specificity, and predictive values of both techniques were determined. The latency from the finding of pathological tracer uptake in BS or PET to the clinical diagnosis of MRONJ and the odds ratio were also calculated.

Results

Sensitivity and specificity of BS for MRONJ prediction were, respectively, 83.3 and 87.5%. Positive and negative predictive values were, respectively, 73.2 and 92.8%. The odds ratio was 35. Sensitivity of PET was 33.3%, specificity was 94.9%, and positive and negative predictive values were 70.0 and 80.0%, respectively. The odds ratio was 9.333. All values were statistically significant.

Conclusions

BS and PET may be accurate techniques for an early prediction of MRONJ.
Semiotics of artificial intelligence: enunciative praxis in image analysis and generation
Authors: Dondero Maria Giulia
Published: February 2025

This paper explores the relation between images and databases in a twofold way. The first part examines image databases as sources for image computational analysis, while the second part studies image databases as sources for image generation (notably through the generative artificial intelligence model Midjourney). Image analysis and image generation will be analyzed through the concept of enunciative praxis. Traditionally, enunciative praxis concerns cultural transformations over the long term (the relation between sedimentation and innovation); in our case it will be used notably to study the generation of new images through old, traditional ones.
Anxiety identity centrality is associated with avoidant coping in anxious adults
Authors: Ahuvia Isaac L. , Eberle Jeremy W. , Schleider Jessica L. , Teachman Bethany A.
Published: February 2025

Introduction: Some have suggested that labeling oneself as having clinical anxiety may promote avoidant coping, which is associated with poor clinical outcomes. However, the construct of anxiety identity centrality (seeing one's anxiety as relatively important to one's self-concept) has rarely been assessed, and its relationship with avoidant coping has not been investigated. Methods: In a sample of 1,234 high-anxiety adults, we analyzed the relationship between anxiety identity centrality and situational and experiential avoidance (preregistration: https://osf.io/g8qh9/ ). A Bayesian ordered probit regression framework was used to model the relationships between ordinal variables. Results: As hypothesized, anxiety identity centrality showed small-to-medium positive correlations with situational (r = .42, p < .001) and experiential (r = .12, p < .001) avoidance. After controlling for anxiety symptom severity, anxiety identity centrality was still positively associated with situational (b = 0.34, 95% credible interval [0.22, 0.48]) and experiential (b = 0.13, 95% CI [0.03, 0.28]) avoidance. Discussion: Anxiety identity centrality is a correlate of avoidant coping that can be measured with a single-item ordinal measure. This study is cross-sectional; we cannot infer causal or temporal relationships between anxiety identity centrality and avoidant coping. Future research should investigate their causal relationship.
Kształtowanie się pojęcia przedsiębiorcy i przedsiębiorstwa w prawie cywilnym oraz prawie gospodarczym w Polsce
Authors:   Uniwersytet w Białymstoku, Zapolska Karolina
Published: February 2025

The proper understanding and later application of the law requires the proper determination not only by the legislator, but also later through the conducted interpretation, among others, by the judiciary, of the concepts falling within the scope of a given legal act. According to the established view in case law, the starting point for the interpretation of the provisions should undoubtedly be the text of the act and the understanding of the words used by the legislator. Legal definitions are primarily helpful in this respect. In business transactions, some of the concepts that have undergone significant evolution are “entrepreneur” and “enterprise”. At the same time, these are terms that play a significant role in the legal order and the economy. Importantly, to this day, the entrepreneur is a concept that is not uniform and there is still a noticeable lack of consistency in its understanding by various branches of law. A similar situation occurs in the case of the concept of “enterprise”, which appears in various legal acts and often in different interpretations. Both concepts have undergone significant evolution, what is more, the terminology in their scope has also changed, as well as the approach to it. Both of these terms also appear in a number of different legal acts in the Polish legal system. Considering that the legislator often decides to introduce his own definition of these concepts for the needs of a specific act, the question arises to what extent the postulate of a rational legislator, or at least the principle of legal certainty, is maintained.
Wpływ polityki historycznej na relacje polsko-litewskie
Authors:   Katolicki Uniwersytet Lubelski Jana Pawła II, Lis Wojciech
Published: February 2025

The article deals with the issue of historical policy and its impact on mutual Polish-Lithuanian relations. The nature of these relations is determined by a number of diverse factors, one of which is the attitude to one’s own past and the ability to emphasize those moments of it that testify to the greatness of the nation and its achievements. The impact of history on the present day, however, is not through historical facts alone, but also, and perhaps above all, through the way they are interpreted and presented to the public, which can boldly be called historical policy. It goes without saying that each state tries to shape this policy in such a way that will allow it to emphasize its value, exaggerate events of fundamental importance to it, and at the same time marginalize or altogether relegate to oblivion everything which is a source of shame. Thus, historical policy can either bring countries that have similar attitudes toward a shared history closer together or distance them when the assessment is diametrically opposed. In this sense, historical policy can either serve to nurture shared memory or to reinforce antagonism. This is of great importance, especially in this part of the world, where history, as perhaps nowhere else, has a tremendous impact on how we define ourselves, how we treat our homeland, how we perceive others and on what rules we base the relationships we build with them. The purpose of this article is an attempt to show the impact of historical politics on Polish-Lithuanian relations. Contrary to popular slogans about “the best ever PolishLithuanian relations,” their actual picture is far from ideal. At the same time, the aim here is not to stoke bad emotions, but to show how relative the perception of common history is, even in the case of nations that for centuries formed a common state. The research was carried out using the methods of critical analysis, dogmatic-legal analysis, and observation of the way interactions are formed.
Relacje między Konstytucją a aktami prawa Unii Europejskiej w orzeczeniach polskiego Trybunału Konstytucyjnego i Sądu Konstytucyjnego Republiki Litewskiej (20 lat doświadczeń orzeczniczych: 2004–2024)
Authors:   Uniwersytet Jana Długosza w Częstochowie, Grzybowski Marian
Published: February 2025

Thee binding constitutions of both, the Republic of Lithuania of October 25, 1992 and the Constitution of the Republic of Poland of April 2, 1997, were developed and afterwards approved in respective national referendum before Lithuania and Poland joined the European Union on May 1, 2004. Immediately after accession, the issue of relationship between constitutional provisions in Lithuania and Poland and the acts of EU laws, their direct application and possible priority in the event of a conflict with statutory regulations and the other act of national law became the sphere which required diligent and univocal decisions. This concerned, in particular, the issue of the direct validity and application of the acts of EU law and the priority of their application when confronted with incompatible norms of Lithuanian and Polish national law. Neither the constitution of Lithuania nor the Constitution of Poland provides detailed rules on these matters. The Constitution of Poland only formulates a general principle, included in Art. 91(1). It allows for the direct application of legal acts adopted by the bodies of an international organization and the assignments constituting a given organization, ratified by the Republic of Poland. There is no such directive in the Lithuanian Constitution of 1992. Due to the characterized situation, both the Lithuanian and Polish constitutional courts were forced to give answers to the indicated question against the background of the specific cases examined by them. The decisions of each of the compared constitutional courts were formulated in the context of cases brought before the Lithuanian and Polish constitutional courts. The carried out analysis, while generally converging on the direction of adjudication, indicates a certain diversification of legal conditions and tenor of specific judgements, as well as non-uniformity of the evolution of jurisprudence over the 20 years covered by the comparison. Presentation and comparison of the mentioned constitutional-legal conditions of adjudication in cases of conflicts between the Lithuanian and the Polish national law and the law of the European Union, mainly: acts of law established by the bodies of the Union, are the aim of the carried out considerations.
The Influence of Personality Traits on Household Financial Decisions: Evidence from 31 European Countries
Authors: Lobão Júlio , Ashqar Rashed Isam
Published: February 2025

Household financial decision-making is a complex process influenced by various factors, including personality traits. This study examines the impact of these on household finance in 31 European countries, utilizing the European Union Statistics on Income and Living Conditions (EU-SILC) dataset from Eurostat. We have employed a logistic regression analysis to investigate the relationship between personality traits and three key dimensions of household finance: the likelihood of holding secured debts, the probability of experiencing financial distress, and the state of financial well-being. Our findings have revealed that high levels of neuroticism and extraversion are linked to a greater likelihood of financial distress, whereas low levels of either of them are associated with a higher probability of holding a mortgage. This study highlights the significance of incorporating personality traits into the analysis of household financial decision-making and provides valuable insights into the determinants of household finance in Europe.
Colonic polyps in North-Western Romania: a comprehensive single-center analysis of endoscopic and pathological features
Authors: Albu Andrada , Baroana Cosmin I. , Farcas Radu A. , Freidrich Eduard , Ismaiel Abdulrahman , Dumitrascu Dan L. , Grad Simona
Published: February 2025

Background and aims. Most colorectal cancers (CRC) originate from precancerous adenomatous and serrated lesions. Accepted risk determinants for conventional adenomas and CRC include age, male gender and familial history. The aim of our study was to outline the characteristics of colorectal polyps in our center, as well as to uncover associations between them and certain clinical presentations.
Methods. We retrospectively collected the data available in a tertiary center of the patients that underwent colonoscopy for various indications (e.g.: rectorrhagia, abdominal pain, screening, anemia etc.) between the 1st of January 2022 and the 1st of August 2023. We analyzed the age, gender and symptoms of the patients. We analyzed the colorectal polyps detected. We classified the polyps based on location, size, shape, architecture and dysplasia grade. Statistical analysis was conducted to evaluate potential associations between their characteristics.
Results. 248 subjects were identified and included in the study. There were 584 polyps uncovered during the colonoscopies in 248 subjects. 498 polyps were excised and retrieved; 44.5% were right-sided and 55.5% were left-sided. Most of the polyps were < 1 cm (78.2%). There were significantly more adenomatous polyps (68.8%) than non-adenomatous (31.2%). Most of the polyps had a low grade of dysplasia (59.8%). There were significant associations between the polyp size and dysplasia grade, number and location on the transverse colon. Polyps under 1 cm were more likely to be tubular (p=0.008). The age of the patients >50 years was associated with a greater number of polyps (p=0.002). There was a moderate statistically significant association (p=0.0297) between the male gender and the number of adenomatous polyps.
Conclusions. Male gender, age greater than 50 years, history of colorectal polyps are risk factors for the development of colorectal polyps in the studied population. A history of more than 2 polyps and a size greater of 1 cm can be associated with higher rates of dysplasia.
Sudden Unexpected Death and Alcohol Addiction: Case Report on Disulfiram Use
Authors: Kondratavičiūtė Gabija , Banionis Dalius , Laima Sigitas , Chmieliauskas Sigitas , Vasiljevaitė Diana , Petreikis Paulius , Badaras Robertas
Published: February 2025

Background: Disulfiram is a type of medication widely prescribed in order to cease alcohol consumption. When used with alcohol, the ‘disulfiram-alcohol reaction’ occurs, causing nausea and vomiting. Disulfiram blocks alcohol dissolving enzymes thus increasing acetaldehyde concentration and inducing the above-mentioned symptoms. These undesirable symptoms are similar to the side effects that occur to oncological patients after the administration of chemotherapy.Materials and methods: Descriptive research method was used. The literature focusing on alcohol, medications and drug consumption was reviewed.Case report: The primary abstinence at the beginning of treatment with Disulfiram does not guarantee that alcohol usage will not get manifested again at the further stages of treatment. Alcohol addiction forces patients to search for a way to avoid the unwanted reactions. Sometimes, patients tend to be quite ingenious while trying to suppress the arising side effects. In many cases, it involves the usage of additional medication.Conclusions: When alcohol addiction overpowers, the patient tries to reduce the undesirable symptoms and may even die if alcohol is combined with disulfiram. Death may occur due to the cardio and neurotoxic effects of acetaldehyde.
Experiences of Nursing Students Working with Nurses during Clinical Practice
Authors: Šulskytė Justė , Spirgienė Lina
Published: February 2025

The aim of the study: to establish nursing students’ experiences of working as a team with nurses during clinical practice. Methods. The qualitative research was carried out between December 2023 and February 2024. 9 female students of the 4th year nursing programme at LSMU were interviewed. Approval for the study was obtained from the LSMU Bioethics Center (No. 2023-BEC2-396, 14 November 2023). Research results. Professional nurses were the key individuals who taught how to perform procedures, communicate with patients, encouraged professional improvement, and provided emotional support in difficult and stressful situations. The participants were pleased when the involved nurses were paying due attention to the process of training and showed the trainees from their own experience how to carry out procedures more effectively. The students positively commented on the nurses’ ability to teach students. According to the research participants, if the students themselves show initiative, nurses willingly involve them in critical situations. By motivating students, nurses can create a stronger bond with them, and, most importantly, encourage them to never give up, and to have more confidence in their own abilities. The experiences of nursing students depended on the course in which they were carrying out their clinical practice. Conclusions. Experiences in the clinical practice influence nursing students’ perceptions of the nursing profession and teamwork. Nursing students stated that they mostly worked in teams with nurses, learning by observing their actions and later trying out their own abilities in various nursing procedures.
Impact of distinct sintering temperatures in pellets to strontium immobilization
Authors: Sanches Gabriella , Silva Araujo Mariana , Mello-Castanho Sonia
Published: February 2025

The immobilization of radioactive strontium (Sr) from liquid effluents, a byproduct of nuclear fission and accidents, presents significant environmental and public health challenges. This study evaluates the immobilization of Sr in a glass matrix by comparing the effects of different sintering temperatures. The analyses started from three temperatures 800ºC, 900ºC and 1000ºC for each of the four compositions, which vary the addition of niobium (Nb) content in the vitreous matrix by 2%, 4%, 6% and 8% in mol. The highest temperature was excluded because its deformation did not match the final objective, at 900ºC the compositions had better results in density and water absorption, so that at the same temperature the composition with 4% niobium responded better to the results. The study underscores the significance of treating temperature and Nb content in the glass matrix for effective Sr immobilization, offering valuable insights for the development of safe and sustainable nuclear waste management strategies.
Integrative Approaches for Precise Identification and Range Delimitation of the Three Most Common European Leiopus species (Coleoptera, Cerambycidae)
Authors: Zamoroka A. M.
Published: February 2025

Leiopus nebulosus (Linnaeus, 1758), L. linnei Wallin, Nylander & Kvamme, 2009 and L. femoratus Fairmaire, 1859 are the three most common European species of the long-horn beetle genus Leiopus Audinet-Serville, 1835. These species have often been misidentified due to their general morphological similarities. This study addresses the need for a simple and reliable method to differentiate L. nebulosus, L. linnei, and L. femoratus. Through the examination of a long series of specimens, specific morphological traits were identified, such as the shape of the femora on all legs and the width of the prosternal process, which allow for rapid and accurate differentiation between the three species. The findings led to the refinement of the diagnostic criteria for these species and the development of a straightforward identification key. Ecological niche modelling was employed to construct accurate global distribution maps for all three species. Additionally, the proposal to conserve the name Leiopus linnei under Article 23.9 of the Code was made.
Ориентализмы тематической группы «Сладкие блюда» в фразеологии южных славян (на фоне других языков)
Authors: Кузнецова И. В.
Published: February 2025

Ориентализмы – слова разных групп тюркских, а также иранских и арабо-семитских языков. Язык османских турок был как источником заимствований, так и посредником проникновения ори-ентализмов (в первую очередь арабизмов и персизмов) в южнославянские языки-реципиенты. В статье анализируются устаревшие и активно употребляющиеся в наши дни на территории Южной Славии фразеологические единицы с компонентами ориентального происхождения, связанными с кухней Востока. Слова заимствовались вместе с реалиями – блюдами восточной кухни. Мы ограни-чились тематической группой «Сладкие блюда» (сахар, халва, рахат-лукум, пекмез, десерты из теста – пахлава, гурабия, мафиш, кадаиф и риса – сутлияш). Названия восточных сладостей вошли в язы-ки-реципиенты в результате языковой коммуникации, сопровождавшей диалог разных культур на протяжении нескольких веков. В статье приводятся некоторые лингвокультурологические и исто-рико-этимологические комментарии к фразеологическим единицам, а также толкование фразеоло-гических оборотов и компонентов, входящих в них. Это необходимо для понимания ментальности носителей того или иного языка, для ознакомления с культурным наследием народа.

Материал исследования – данные словарей и интернет-источники. При обработке фразеологиче-ского материала применялись синхронно-описательный метод, метод анализа компонентов, метод лингвокультурологического анализа, прием выборки фразеологизмов из словарей и интернет-ре-сурсов. Привлечение фразеологического материала других языков (восточно- и западнославянских и неславянских) позволило выявить универсальность или национальную специфику анализируе-мой южнославянской фразеологической единицы. Фразеологический материал показывает, как в разные языки входили заимствования-ориентализмы восточной кухни, демонстрирует разный фразеологический потенциал восточных сладостей, ареальную проекцию фразеологизма (или от-сутствие таковой). В силу разных причин (исторических и существующих ныне) названия сладких блюд ориентальной кухни чаще встречаются в боснийских фразеологических единицах. Варианты фразеологизмов иллюстрируют параллельное использование в некоторых структурно-семантиче-ских моделях ориентализмов и славянизмов или германизмов. Фразеологизмы со «сладким» компо-нентом характеризуют как человека, так и внешний по отношению к нему мир.
Фразеологія у змінних полюсах інфопростору (моніторинг медіа та створення фразеоматриці)
Authors: Сизонов Дмитро
Published: February 2025

У статті подано результат комплексного скринінгу сучасних українських (для порівняння акцен- товано увагу на польських й угорських) медіа для з’ясування маніпулятивної функції фразеологіз- мів. Автором подано типові моделі функціонування фразеологічних одиниць у масовій комунікації (зазначення зон семантичних зіткнень), які становлять певну матрицю динамічних процесів сучас- них мов. У сучасних медіа автори все частіше звертаються до фразеології як сучасного маніпулятив- ного ресурсу, що допомагає донести «правильну» думку до реципієнта. Особливо дієвими виявля- ються фразеологізми у заголовках, які виконують роль смислового центру медіастатей. Також нами розглянуто фразеологізм в інших частинах медіатексту – підзаголовку та висновку, в яких фразео- логія виконує пʼять ключових функцій – смислову, роз’яснювальну, інформативну, акцентуальн y та алюзійну. Важливо, що кожна із функцій відповідає вимогам часу та критерію фактологічності, що допомагають при створенні медіатексту. За нашими спостереженнями, найбільше фразеологізми з маніпулятивною метою використовуються в інтернет-комунікації, яка характеризується особливим динамізмом та інформаційною резонансністю. Доведено, що фразеологія як вербальний культур- ний код здатна впливати на реципієнта, враховуючи його фонові знання. А тому до уваги бралися медіаресурси, що мають велику аудиторію читачів (друкована преса) / глядачів (телебачення, інтер- нет) / слухачів (радіо). Важливо, що автором узяті до уваги медіаресурси, обмежені часом (адже піс- ля 24 лютого 2022 року у звʼязку з повномасштабним вторгненням Росії на територію України деякі національні медіа змінили свою сітку мовлення та контент або ж зовсім зникли з інформаційного поля). На наше переконання, обʼєктивація отриманих даних залежить від рівномірного моніторин-гу медіаджерел (це і передбачено в нашому дослідженні, коли під аналіз потрапили різноформатні та різножанрові ЗМІ – друковані та електронні). Особливу роль у статті відведено новим фразеоло- гізмам, що виникають як: (а) мовленнєві роздуми про суспільно-політичні зміни (екстралінгваль- ний фактор); (б) типове явище «мовної моди» (інтралінгвальний фактор); (в) маніпулятивний універсум масової свідомості (психолінгвальний фактор); (г) мовленнєвий репрезентант глобаль- них інформаційних змін у світі (технологічний фактор). Динаміка мовних процесів залежить від прогресивних змін мовних систем та еволюції функціональних стилів, зокрема розширення меж медіастилю (виникнення нової інформаційної сфери → поява нового медіаджерела → поява нового маніпулятивного засобу → поява нового фразеологізму).
Madeira, Port, Sherry: The Equinox Companion to Fortified Wines
Authors: Nagórka Piotr
Published: February 2025

Madeira, Port, Sherry: The Equinox Companion to Fortified Wines fills a niche for all those seeking to understand the fortified wine industry as a whole: its history, producers, winemaking methods, and practical aspects of enjoying these unique wines, numbered among the world’s most long-lived beverages. This book constitutes an educational compendium representing organised cutting-edge knowledge on the three classic fortified wines, brought to us by the Iberian culture. The reference work enables an appreciation of the histories of madeira, port and sherry against the background of world-changing events. Extensive terminological research has distilled years of professional knowledge into a reliable compendium, taking the reader on unique educational journeys through winemaking activities, from selection of grapes to bottle ageing. The companion offers comprehensive terminological coverage, including classifications and serving temperatures, as well as the intricacies of flavour compounds, responsible for various notes identified in wine bouquets, such as those of an old blended madeira, a vintage port, or a palo cortado sherry. Guidelines on wine and food pairing have been included to ensure the companion’s suitability for a wide audience of readers: from wine experts to connoisseurs, from gourmet restaurant chefs to home cooks.
Evaluation of Segregating Generations of Upland Cotton (Gossypium hirustum L.)
Authors:   Werer Agricultural Research Center, Ethiopian Institute of Agricultural Research, Ethiopia, Alehegn Workie Amanu , Hussien Mohammed ,   College of Agriculture, Hawassa University, Ethiopia, Berhanu Amsalu ,   Melkassa Agricultural Research Center, Ethiopian Institute of Agricultural Research, Ethiopia
Published: February 2025

The present study contained 16 testing genotypes and was laid out in a Randomized Complete Block Design (RCBD) with four replications at Werer Agricultural Research Center (WARC). This experiment was conducted with the objective of evaluating the performance of segregating inbred lines. The analysis of variance revealed that the tested genotypes differed significantly (p<0.05) in number of sympodial branches plant-1(SYM), Plant height (PLH), boll number plant-1 (BOP), Boll weight (BOW), Seed cotton yield ha-1 (SHA),Ginning percentage (GP),and lint yield ha-1(LHA), hundred seed weight (HSW), micronaire (Mic), upper half mean length (Uhml), Fiber Strength(Str) and Short fiber content (Sf). A one degree of contrast between the mean of the 14 F5 inbred lines and the mean of the two parents was significant for all traits except some traits. All 14 inbred lines included in this study were better than both parents in SYM, BOP, SHA, GP, and LHA, but were inferior to both parents in BOW, indicating that there was transgressive expression of the majority of traits. Additive genes were dispersed in the two parents for these traits. The mean separation analysis of seed cotton yield revealed superior inbred lines that excelled their parents viz., K (5170.3kg/ha), G (5072 kg/ha) and I (4987 kg/ha). The yield advantage obtained from most of the inbred lines was more than 10% in both seed cotton yield and lint yield compared with the parents. The inbred line with the highest value was superior to the parent with the highest value by 34% in SYM (inbred line I (15.25 vs 11.38), by 39.94% in BOP (inbred line I; 17.59 vs 12.57), by 26.7% in SHA (inbred line K; 51.7 vs 40.8), by 33.1% in LHA (inbred line K; 20.92 vs 15.72). Deltapine-90 was inferior to Delecero in Upper half mean length (Uhml) (27.90 vs 32.92), Uniformity percentage (80.4 vs 83.88), and in Strength (25.78 vs 36.33). The higher fiber quality of Delecero was expressed in its higher Uhml, strength, and its lower percentage of short fiber content (Sf, 8.0%).Deltapine-90 could not contribute any additive genes for the improvement of fiber quality traits like Uhml, strength and uniformity. It had one of the lowest means for the three traits. Breeders should look for appropriate germplasm that can contribute to the improvement of these fiber quality traits. Delcero should be backcrossed, with high yielder inbred lines to transfer its main fiber quality trait like fiber strength and length. Thus, these inbred lines could be potential varieties for future use by combining important quality traits through back crossing.
Effects of Rhizobium Inoculation and Phosphorus Fertilizer rates on Nitrogen Fixation and Nutrient up take of Chickpea (Cicer arietinum L.) at Goro, Bale Zone, Oromia Regional State.
Authors:   Sinana Agricultural Research Centre, Bale-Robe, Ethiopia, Tamiru Meleta , Girma Abera ,   Hawassa University College of Agriculture, Hawassa
Published: February 2025

Chickpea response to two varieties of chickpea (Arerti and Habr), two Rhizobial inoculants (EAL 018 and EAL 029) and five P rate (0, 15, 30, 45 and 60 kg P2O5 ha-1) were studied in split plot arrangements. Main plot consisted of varieties whereas P2O5 levels and Rhizobium strains were kept in subplot. The experiment was laid out at Goro, Bale Zone, Oromia Regional State during 2015/16 with the objective to determine the effectiveness of Rhizobium strains and phosphorus fertilizer application on two varieties of chickpea (Arerti and Habru).The nodulation rating, nodule volume and color were not significantly affected due to varieties. However, significant variation (P <0.05) was observed in number of nodule per plant (NNPP) and nodule dry weight (NDW) between varieties of chick pea, maximum NNPP and NDW was obtained from Arerti variety. All the nodulation parameters were significantly (P<0.05) affected due to rhizobium inoculation and P2O5 except the nodule color. Maximum nodulation parameters were recorded at 45 and 60 kg P2O5 ha-1and inoculation by EAL 029 strain except the nodule color. Significant interaction effect was observed between variety and Rhizobium inoculation for nodule rate (NR), NDW between variety and P2O5, rhizobium and P2O5 and also interaction effect between varieties, Rhizobium and P2O5 on NR and NDW. The N and P uptake at mid flowering, %Ndfa, grain, straw and total N and P content and crude protein content were significantly affected by variety, rhizobium inoculation and application of P2O5. Maximum response was obtained from EAL 029 strain inoculations and application of 45 kg P2O5 ha-1 for N uptake, seed N and P uptake were maximum at 45and 60 kg P2O5 ha-1 respectively. The current investigation indicated that Arerti variety inoculation with Rhizobium strain EAL 029 along with application of P2O5 at rate of 45 kg ha-1 found to be appropriate for chickpea production in the study area. The current investigation indicated that the use of P2O5 with Rhizobium inoculation as a nutrient management strategy could increase chick pea production. Since the experiment was conducted only for one year, we suggest the results to be verified with more varieties of chickpea and rhizobium strain under the same agro-climatic conditions.
Influence of gamification on skill-based training of surgical residents
Authors: Topalli Damla , Tokdemir Gul , Cagiltay Nergiz Ercil
Published: February 2025

Potentially games increase motivation and thus support the learning process. Gamification effect on different skill levels of surgical residents was limitedly studied. This study aims to better understand the effect of motivation gained through gamification on simulation-based surgical training environments for novice and intermediate surgical residents' performances. An educational scenario with a haptic interface is designed in two versions: gamified and non-gamified. The tasks are performed twice, with the dominant and non-dominant hands resemble the task difficulty. 26 novice and intermediate surgical residents were randomly assigned to one of the groups (gamified or non-gamified). Gamification positively improved novice surgical residents’ performances under both hand conditions. However, surprisingly, in some situations, results indicated lower performance by the intermediates compared to the novices. A flow model for this specific scenario is proposed. To benefit the gamification effect, learners’ skill levels and content should be carefully assessed and balanced on simulation-based surgical skill training materials.
The meaning that undergraduate Occupational Therapy students at the University of KwaZulu-Natal attach to the Occupation of dance
Authors: Lingah Thanalutchmy , Paruk Juwaiyyira
Published: February 2025

Introduction: Occupational Engagement is an inextricable component of life and is considered essential to human survival. Doing an occupation that is positively perceived (such as dance) can lead to the experience and expression of meaning which then enhances quality of life. This study aimed to explore the meaning that undergraduate Occupational Therapy students studying at the University of KwaZulu-Natal attach to dance as an occupation.Method: The study followed an exploratory qualitative research design with purposive sampling. Focus groups and semi-structured interviews were utilized to collect data which were analysed thematically.Results: Five themes emerged: Centre stage (an exploration of factors motivating engagement); On Pointe (beneficial effects of dance); My Solo Dance Experience (the individual's journey whilst engaging); It Takes 2 to Tango (exploring the role of relationships) & Dancing to the Beat (exploring time available for engagement). The hidden complexities of 'meanings' attached to the occupation of dance emerged which were experienced as subjective and multi-dimensional.Conclusion: The study revealed that the meanings attached to dance were based on individual experiences with the occupation, others, and the environment. Engagement in the occupation of dance (doing) enhances personal growth (becoming) and becomes a part of the individual (being).
Factors Affecting Parental Intent to Vaccinate Against COVID-19 in Kansas
Authors: Duncan Leah
Published: February 2025

Introduction. Vaccines have been highly effective in reducing severe illness and death from COVID-19, but vaccine hesitancy remains a significant barrier to achieving herd immunity. This study aimed to identify the factors influencing parental decisions regarding COVID-19 vaccination for their children in Kansas, including demographic variables, trust in medical professionals, and the impact of misinformation.
Methods. Data were analyzed from Phase 3.7, Week 53 of the United States Census Bureau’s Household Pulse Survey (N = 68,504), collected between January 4 and January 16, 2023. The analysis focused on data specific to the state of Kansas (N = 1231), using standard descriptive statistics to assess the findings.
Results. The respondents were predominantly middle-aged, female, and Caucasian, with a high level of educational attainment and health insurance coverage. Among respondents, 45.7% had children under 18 living in their household. Of these, 73.5% expressed concerns that led them to refrain from vaccinating their children against COVID-19. The primary reasons for hesitancy included concerns about potential side effects, distrust in the vaccine's safety for children, and the belief that their children were not part of a high-risk group.
Conclusions. These findings underscore persistent concerns about COVID-19 vaccine safety and efficacy among parents, even within a relatively well-educated and insured population. Addressing these concerns with targeted public health messaging and education could be essential in increasing vaccination rates among children in Kansas.
`Second test
Authors: Joe
Published: February 2025

test second
BAF_S04_LABCONCO freeze dryer v1
Authors: Sherman Nicholas , Santos-Ortega Yulica
Published: February 2025

General operation of the Lyophilizer unit.
Immersion in Discomfort: At the Intersection of Worldviews Toward Co‐Governing With Integrity
Authors: Sacedon Randa , Boehme Tillmann , Croft Freya , Edwards Jodi , Farmery Anna , McNeill Eleanor , Solitei Makrita , Voyer Michelle
Published: February 2025

In the drive to embrace more inclusive, equitable, and respectful approaches to research, academics are increasingly encouraged to engage with diverse and alternate knowledges, including with First Nations and Indigenous Communities. Yet for those working at the intersection of different worldviews—known as the “cultural interface”—the experience can be accompanied by feelings of discomfort. We recognise discomfort as a personal, inner emotion of vulnerability that alerts us to unspoken, difficult conversations; to challenged beliefs and assumptions; and to the limits of our own knowledge. As a group of academics working at the cultural interface, we identify common themes across our collective experiences of discomfort, including fragility and guilt, helplessness, fear, ignorance, shame, challenged conceptions of time, and finally connection and relationality. By openly discussing and confronting our experiences of discomfort, we demonstrate that immersion in discomfort is a journey that provides opportunities for learning, understanding, and fostering co‐governing partnerships with integrity.
Smear layer removal potential of a naturally occurring antioxidant: An in-vitro scanning electron microscopic study
Authors: Shenvi Suresh , Joshi Sonal B
Published: February 2025

The primary objective of endodontic therapy is to thoroughly disinfect the root canal system. The smear layer formed during instrumentation presents a substantial impediment to optimal root canal disinfection, as it provides a medium for bacterial proliferation, hinders the penetration of disinfecting agents, and creates a physical barrier that undermines the efficacy of root canal sealers by obstructing the interface between the obturating core material and the dentinal tubules. Consequently, the removal of the smear layer is of utmost importance.

This in vitro study assessed the efficacy of 20% N-acetyl-cysteine (NAC) and 17% ethylenediaminetetraacetic acid (EDTA) in removing the smear layer from root canal dentine.

Ninety-two single-rooted teeth were instrumented and divided into two groups: 20% NAC for 1 minute, and 17% EDTA for 1 minute. Following irrigation, the samples were analyzed using scanning electron microscopy (SEM) to evaluate smear layer removal in the coronal, middle, and apical thirds of the root canals.

No statistically significant difference was observed between 20% NAC and 17% EDTA in their ability to remove the smear layer across all sections of the root canal.

20% NAC demonstrates smear layer removal capability comparable to 17% EDTA as a final irrigant.
Single-visit MTA apexification: A progressive approach for immature teeth with Ellis Class IV fractures- case report
Authors: Balaji S , Panwar Neeraj Kant , Niharika Nishma , Stalin A Arivu , Dwivedi Viidii , Chaurasia Parth , Das Meghna
Published: February 2025

Trauma to developing teeth can disrupt root formation, leading to an open apex and complicating endodontic treatment. Apexification is essential in managing immature non-vital teeth to induce a calcified apical barrier for effective obturation. Traditionally, calcium hydroxide has been the material of choice, but it presents challenges such as extended treatment time and risk of root fractures. Mineral trioxide aggregate (MTA) has emerged as a reliable alternative, offering faster treatment with fewer complications.

A 12-year-old male presented with a history of trauma to the maxillary central incisors (teeth 11 and 21), resulting in Ellis Class IV fractures. The trauma occurred six months prior during a fall. Clinical examination revealed pulpal necrosis, and radiographs confirmed incomplete root formation with open apices. The patient underwent root canal therapy, including pulpal debridement and one-visit apexification with MTA to induce an apical barrier. The MTA was compacted at the apical ends of the canals to provide immediate sealing.

Root canal obturation was successfully completed, and radiographic follow-up demonstrated satisfactory apical sealing. The patient experienced no post-operative complications, and long-term follow-up will be conducted to monitor root maturation and tooth stability.

MTA provides an efficient, biocompatible alternative to calcium hydroxide in apexification, offering faster treatment and reduced risk of root fracture. One-visit apexification with MTA can be considered a viable treatment for non-vital immature permanent teeth with open apices.
Customised vaginal dilator: A case report
Authors: Srivastava Ayush , Gopi Anup
Published: February 2025

Vaginal agenesis, which occurs in approximately 1 in every 5,000 to 7,000 female births. In place of the vagina, there is typically a small pouch or dimple that is 1 to 4 cm in depth. The treatment may either be a surgical or non-surgical method, but the chosen method needs to be tailored to the individual’s needs. The non-surgical creation involves the dilator expansion methods that have been in use for decades. This involves the use of graduated dilators to gradually increase the caliber to a predetermined size.
Assessment of Readiness for Attracting Medical Tourists in the Hospital Setting: A Survey in Western Iran
Authors: Shoara Zahra , Sadeghifar Jamil , Momeni Khalil , Bazyar Mohammad , Khodayari- Zarnaq Rahim , Heydari Maryam
Published: February 2025

Background: Efficient utilization of hospital beds is a key priority for healthcare systems today. Leveraging the potential of medical tourism can serve as a significant strategy in this regard.
Objectives: The purpose of this study was to assess the readiness of hospitals in Ilam city to attract medical tourists.
Methods: This descriptive cross-sectional study was conducted among educational and private hospitals in the center of Ilam province in 2023. Data were collected using a standard checklist designed to evaluate the International Patient Department (IPD), comprising 66 questions across five domains. The checklist was completed through observation, interviews, and a review of available documents. Data analysis was conducted using frequency and percentage distribution tables, means, and standard deviations in Excel software.
Results: The highest readiness score for obtaining a license to establish an International Patient Department was achieved by Kowsar Private Hospital, with a score of 198. The lowest score was recorded at Razi Public Hospital, with a score of 119. Overall, none of the hospitals studied reached the cutoff score of 227 (65%).
Conclusions: The results indicate that all the hospitals studied are currently in an unacceptable state of readiness to attract medical tourists. Establishing International Patient Departments should be a top priority for improving hospital efficiency and fostering the growth of medical tourism.
Conventional and Molecular Characterization Based Microbial Assessment of Street Vended (Vada pav) Samples from Anand City, Gujarat, India
Authors: Mall D.P. , Patel V.H. , Subhash R.
Published: February 2025

Background: Street foods offer convenient meal options for the consumer, but pose safety concerns if not handled or served with proper hygiene. The purpose of the present study was the microbial evaluation of street vended Vada pav samples sold at popular locations in Anand city using the conventional culture technique and molecular characterization via Polymerase Chain Reaction.
Methods: Duplicate samples were collected from seven different locations (n=14) across five zones: East (2), West (1), North (1), South (1), and Central (2) during June 2023. Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Salmonella spp. were isolated and identified. For the microbial screening, bacterial enumeration, colony morphology, Gram's reaction, and biochemical characterization were performed. Amplification of nuc (S. aureus), nheA (B. cereus), phoA (E. coli), and 16S rRNA (Salmonella spp.) genes were carried out via Polymerase Chain Reaction assay. 
Results: Total Viable Count (TVC) ranged from 3.93 to 6.08 log Colony Forming Units (CFU)/g while the Yeast and Mold Counts ranged from 2.30 to 4.28 log CFU/g. Using the conventional culture technique, the prevalence of S. aureus, B. cereus, and E. coli were found to be 3/14, 2/14, and 3/14, respectively; whereas based on molecular characterization, the prevalence was 0/14, 2/14, and 3/14, respectively. Salmonella spp. was not detected in any of the samples.
Conclusion: The study indicates a potential health hazard for consumers due to microbial contamination of street vended Vada pav samples. Consequently, it is crucial to regulate and improve hygienic practices in street food vendors.
O symbolice XIV-wiecznych scen rodzajowych, ukazanych w rzeźbie architektonicznej dwóch fryzów impostowych kolegiaty w Sandomierzu
Authors: Tuszyńska-Szczepaniak Olga
Published: February 2025

Gotycka kolegiata pw. Narodzenia Najświętszej Maryi Panny w Sandomierzu, ufundowana przez Kazimierza Wielkiego, zyskała ciekawy zespół rzeźb architektonicznych w obrębie zworników, wsporników i fryzów impostowych, z których większość stanowi przykłady plastyki wysokiej klasy. W bogatą dekorację floralną, zdobiącą strefę kapitelową świątyni, wpleciono wizerunki zwierząt i fantastycznych stworzeń. Na szczególną uwagę zasługują dekoracje rzeźbiarskie fryzów dwóch par filarów znajdujących się na linii dwóch wejść do świątyni – północnego i południowego. Przedstawiają one pościg psów za zającem i psa poganiającego jeża. Sceny te są wyjątkowe nie tylko ze względu na widoczne interakcje, które niosą za sobą treści symboliki średniowiecznej, ale też możliwość podjęcia próby zrozumienia programu ideowego rzeźby architektonicznej kolegiaty sandomierskiej. Kluczem do jej zrozumienia są teksty Ojców Kościoła, fizjologi i bestiariusze wraz z bogatą ikonografią średniowieczną.