bluuebunny/crossref_metadata_2025 huggingface dataset:
Increased starting doses of exogenous gonadotropins do not improve IVF-ET outcomes in expected poor ovarian responders
Authors: Xiao-Yan Xu , Wu Zhi-Juan , Qi Ying-Hua , Pang Cong-Hui , Sun Zhen-Gao , Song Jing-Yan
Published: May 2023

Background To evaluate whether increasing the starting dose of exogenous gonadotropins (Gn) improves in vitro fertilization and embryo transfer (IVF-ET) outcomes in patients with the expected poor ovarian response (POR), as defined by antral follicles count (AFC) ≤ 9. The outcomes of IVF-ET in patients with expected POR between January 2016 and December 2021 were compared retrospectively. A total of 2448 IVF cycles were studied, including 709 with a starting Gn dose of 150 IU (Group A), 1006 with 225 or 300 IU (Group B), and 733 with 375 or 450 IU (Group C). The cumulative live birth rate was the primary outcome, with secondary outcomes including the number of oocytes retrieved, the number of normal fertilization, the number of transferable embryos, positive pregnancy, clinical pregnancy, pregnancy loss, ectopic pregnancy of fresh embryo transfer, and cycle cancellation rate. Multivariate logistic regression analysis was used to control the confounding factors.Results The cumulative live birth rates (28.2% in group A vs. 23.6% in group B vs. 17.9% in group C, P < 0.001) were statistically significant. The relationship between cumulative live birth rate and grouping was investigated using multivariate logistic regression. The odds ratio (OR) of group B versus group A was 0.887, 95% confidence interval (CI) 0.655–1.174, P = 0.378, and the OR of group C versus group A was 0.77, 95% CI 0.545–1.089, P = 0.139. The total number of retrieved oocytes was 4.49 ± 3 in group A, 4.53 ± 2.8 in group B, and 3.91 ± 2.6 in group C. P < 0.001 indicated that the differences were statistically significant. Multivariate logistic regression was used to investigate the relationship between the number of retrieved oocytes and grouping. The OR of group B versus group A was 0.993, 95% CI 0.713–1.383, P = 0.966, and the OR of group C with group A was 0.881, 95% CI 0.614–1.264, P = 0.492.Conclusions Increasing the starting dose of Gn did not increase the number of oocytes retrieved or the cumulative live birth rate in POR patients.
The Italian Version of the Majeed Pelvic Score: Translation, Cross-Cultural Adaptation and Validation
Authors: Cattaneo Stefano , Vittone Giulio , Galante Claudio , Domenicucci Marco , Milano Giuseppe , Casiraghi Alessandro
Published: May 2023

Purpose The assessment of functional outcomes after pelvic ring fracture remains a controversial topic. The Majeed pelvic score (MPS) is the most commonly used pelvic-specific questionnaire in the literature. The aim of this study is translation, cross-cultural adaptation and validation of the Italian version of MPS.Methods The study was articulated in two phases. Phase 1 consisted in translation and cross-cultural adaptation of MPS, from English into Italian. The psychometric properties were tested on 52 Italian patients (Phase 2). Construct validity was assessed by correlation with Short-Form 12 (SF-12). 33 patients repeated the questionnaire after 14 days to assess its reproducibility. All data were subsequently analyzed (descriptive statistics, multitrait analysis, reliability and construct validity assessment).Results The questionnaire was clear and easily understood (no missing data). A ceiling effect was detected for all items of the scale. Multitrait analysis showed good results for each outcome measure, except for the item “walking distance” that showed poor item discriminant validity. A significant correlation between the MPS and the physical component summary (PCS) of the SF-12 was found, while there was a weak correlation with the mental component summary (MCS). The questionnaire showed high internal consistency (Cronbach’s alpha: 0.91–0.99) and very good test-retest reliability (intraclass correlation coefficients: 0.92–0.96).Conclusions The Italian version of the MPS has demonstrated to be reliable and valid in the evaluation of patients with pelvic ring fractures. There is still however a need for an instrument capable of evaluating the mental component in these types of injuries.
Prevalence and risk factors of Neospora caninum in aborted fetus of sheep, goat, cattle, and buffalo
Authors: Shahiduzzaman Md. , Biswas Pijush , Kabir Ajran , Wakid Majed H. , Ahmed Nurnabi , Hossain Md. Zawad , Amin A R M Beni
Published: May 2023

BackgroundNeospora caninum, a protozoa that is a leading cause of neurological illness in dogs (definitive host), abortion in cattle (intermediate host) and sporadic disease in other livestock species (sheep, goats, horses and other carnivores). The study was aimed to reveal the molecular epidemiology ofN. caninumin aborted fetuses of cattle, goats, sheep and buffaloes in Bangladesh.MethodsIn total, 157 aborted fetuses (50 Cattle, 46 Buffaloes, 34 Goats and 27 Sheep) were randomly collected from various regions of Bangladesh. DNA was extracted from brain tissue to perform nested PCR and sequencing of ITS1 rDNA gene ofN. caninum.ResultsA total of 20 aborted fetuses out of 157 were positive forN. caninuminfection. Higher prevalence was observed in cattle (16.0%) followed by sheep (14.8%), goats (11.8%) and buffaloes (8.7%). Highest prevalence was found in animals during second trimester (21.51%) with aged 2 to 4 years (15.8%). Sequences from representative positive samples showed similarity between 99–100% forN. caninumITS1 rDNA gene with other best hit scoring GenBank sequences. Multivariate logistic regression demonstrated that abortion in pregnancy, abortion history of the animals, contact with dog feces or presence of dog in animals farm or premises and management practices were significantly (p ≤ 0.001) correlated withN. caninuminfection.ConclusionThe study findings indicated thatN. caninuminfection is one of the major causes of abortion and economic loss in livestock farming. Broader molecular epidemiology is imperative for strategic planning to control and prevent neosporosis in livestock.
LINC00606 regulates glioblastoma progression by sponging miR-486-3p and interacting with ATP11B
Authors: Dong Naijun , Qi Wenxin , Wu Lingling , Li Jie , Zhang Xueqi , Wu Hao , Zhang Wen , Jiang Jiawen , Zhang Shibo , Fu Wenjun , Liu Qian , Wang Jiao , Zhao Robert Chunhua
Published: May 2023

Background
LncRNAs regulate tumorigenesis and development in a variety of cancers; nevertheless, the biological functions and molecular mechanisms of LINC00606 in glioblastoma (GBM) remain largely unknown.
Methods
The expression of LINC00606 and ATP11B in glioma and normal brain tissues was evaluated by qPCR, and the biological functions of the LINC00606/miR-486-3p/TCF12/ATP11B axis in GBM were verified through a series of in vitro and in vivoexperiments. The molecular mechanism of LINC00606 was revealed by immunoblotting, FISH, RNA pulldown, CHIP-qPCR, and a dual-luciferase reporter assay.
Results
LINC00606 is highly expressed in GBM patient samples and is related to the poor prognosis. Here, LINC00606 promoted the proliferation, clonal expansion, and migration of glioma cells and reduced the levels of apoptosis. LINC00606 targets TCF12 by sponging miR-486-3p, which has been proven to affect the transcriptional initiation of LINC00606, PTEN, and KLLN. In addition, by working in concert with ATP11B, LINC00606 regulates the PI3K/AKT signaling pathway to mediate the proliferation, migration, and apoptosis of glioma cells.
Conclusion
The LINC00606/miR-486-3p/TCF12/ATP11B axis is involved in the regulation of glioma progression and plays a specific regulatory role at both the transcriptional and post-transcriptional levels via the sponging of miR-486-3p by LINC00606 to target TCF12 and the interaction of LINC00606 with ATP11B, interference with which may prove to be a new strategy for the treatment of glioblastoma.
Cost analysis of Telemedicine use in Pediatric Nephrology -The LMIC perspective
Authors: Dev Vishnu , Mittal Aliza , Joshi Vibha , Meena Jitendra Kumar , Goel Akhil Dhanesh , Didel Siyaram , Pareek Puneet , Misra Sanjeev , Singh Kuldeep
Published: May 2023

Background
The overall cost of managing chronic diseases is a significant barrier to accessing complete and timely healthcare, especially in rural and geographically isolated areas. This cost disparity becomes more pronounced in the case of children and more so in under-resourced regions of the world. In the era of COVID-19, as the need for physical distancing increased, there was a transition in approach to healthcare provision to Telemedicine consultations. The cost saving using teleconsultations is evaluated in this study in a pediatric nephrology clinic.
Methodology
This prospective cohort study was conducted at a tertiary care center in western Rajasthan from March 2021 to October 2022. All consecutive pediatric (29 days -18 years) patients attending telemedicine services for renal-related illness were enrolled. Basic demographic details were collected. The cost analysis was done after six months, in terms of perceived cost savings by a telemedicine consultation compared to an in-person visit during six months starting from enrolment.
Results
One hundred twelve patients were enrolled. Two hundred sixty-six teleconsultations attended. The 109 patients who could be followed up saved INR 4,57,900 during six months of follow-up. ( 3 lost to follow-up). The average cost saving was INR -1577/patient/visit. The patients saved 4.99 % of the family income [Median of 2.16 %( IQR: 0.66-5.5 %)]. The Highest expenditure per visit was incurred for food and transport. The median distance from the residence to the clinic was 122.5 km (IQR: 30-250). Over the six-month study period, our patients have saved a travel distance of 83274 km. (743 km per patient).
Conclusion
The use of telemedicine as a follow-up method helps save significant costs and distances travelled by patients.
Between Reality and Delusion: Challenges of Applying Large Language Models to Companion Robots for Open-Domain Dialogues with Older Adults
Authors: Irfan Bahar , Kuoppamäki Sanna-Mari , Skantze Gabriel
Published: May 2023

This work aims to provide initial guidelines towards developing companion robots with large language models (LLMs) to be part of everyday lives of older adults. Using iterative participatory design (co-design) approaches, we analyze the challenges of applying LLMs for multi-modal open-domain dialogue, deriving from older adults' (one-to-one) interactions with a personalized companion robot, built on Furhat robot with GPT-3.5. An initial study with 6 Swedish-speaking older adults (65 and older) showed that the robot frequently interrupted the users, responded slowly and repetitively, engaged in superficial conversations, and caused a barrier in the interaction due to foreign language (English). Upon incremental technical developments to address these issues, participatory design workshops were conducted with 28 Swedish-speaking older adults. While the interactions (in Swedish) were smoother, less disrupted, and more varied in topics and responses, further challenges were observed due to hallucinations and obsolete information, and disengagement cues, causing frustration, confusion, and worry.
Investigations on the effects of forming conditions on the deformation behaviors of copper-steel bimetallic rods during cold drawing processes
Authors: Hwang Yeong-Maw , Tsui Hiu Shan Rachel , Lu Cheng-Yu
Published: May 2023

Metal composites are widely used in different industries owing to their significant improvement in material properties such as mechanical strength, electrical conductivity, and corrosion resistivity compared to traditional metals. Such composites can be manufactured and processed in different ways to achieve the desired geometry and quality, among different metal forming techniques, drawing is the one that can be used to produce metal composites from raw materials or as a secondary processing method for metal composites. The drawing processes of the two cases are basically the same except for the initial bonding conditions of the billets. In this paper, bimetallic rods with AISI-1006 Low Carbon Steel core and C10100 Oxygen-Free Electronic Copper sleeve are modeled using finite element software DEFORM. The simulation models are verified by drawing experiments. The effects of initial bonding conditions, initial core ratio, reduction ratio, semi-die angle, drawing speed, and friction on the plastic deformation behaviors of the bimetallic rods are investigated. The results indicate that the initial bonding conditions have a great impact on the deformation behaviors of the billets in terms of strain distribution, material flow, residual stress, and final core ratio. With the aid of these analyses, the drawing process and the quality of the products can then be controlled more easily.
Deep Learning Based Analysis of Student Aptitude for Programming at College Freshman Level
Authors: Narasimhan Lakshmi , Basupi G.
Published: May 2023

Predicting Freshman student’s aptitude for computing is critical for researchers to understand the underlying aptitude for programming. Dataset out of a questionnaire taken from various Senior students in a high school in the city of Kanchipuram, Tamil Nadu, India was used, where the questions related to their social and cultural backgrounds and their experience with computers. Several hypotheses were also generated. The datasets were analyzed using three machine learning algorithms namely, Back-propagation Neural Network (BPN) and Recurrent Neural Network (RNN) (and its variant, Gated Recurrent Network (GNN)) with K-Nearest Neighbor (KNN) used as the clas-sifier. Various models were obtained to validate the underpinning set of hypotheses clusters. The results show that the BPN model achieved a high degree of accuracies on various metrics in predicting Freshman student’s aptitude for computer programming.
Nanophotonic Resonator Assisted Photonic Spin Hall Enhancement for Sensing Application
Authors: Goyal Amit Kumar , Divyanshu Divyanshu , Massoud Yehia
Published: May 2023

This manuscript presents a dielectric resonator structure with altered dispersion characteristics to enhance the photonic spin hall effect (PSHE). The structural parameters are optimized to enhance the PSHE at 632.8 nm operating wavelength. The thickness-dependent angular dispersion analysis is carried out to optimize the structure and obtain the exceptional points. The PSHE-induced spin splitting shows a high sensitivity to the optical thickness of the defect layer. This gives a maximum PSHE-based transverse displacement (PSHE-TD) of around 56.66 times the operating wavelength at an incidence angle of 61.68°. Moreover, the structure’s capability as a PSHE-based refractive index sensor is also evaluated. The analytical results demonstrate an average sensitivity of around 33,720 μm/RIU. The structure exhibits around five times higher PSHE-TD and approximately 150% improvement in sensitivity than the recently reported values in lossy mode resonance structures. Due to the purely dielectric material-assisted PhC resonator configurations and significantly higher PSHE-TD, the development of low-cost PSHE-based devices for commercial applications is envisaged.
FAHR SYNDROME REVEALED BY A CONVULSIVE CRISIS ASSOCIATED WITH IATROGENIC HYPERPARATHYROIDISM: CASE REPORT
Authors:   Reception Service And Vital Emergencies, CHU Med VI of Marrakech Morocco., Benothman Najoua , Elkayla Fadoua ,   Reception Service And Vital Emergencies, CHU Med VI of Marrakech Morocco., Rhezali Manal ,   Reception Service And Vital Emergencies, CHU Med VI of Marrakech Morocco., Abouelhassan Taoufik ,   Reception Service And Vital Emergencies, CHU Med VI of Marrakech Morocco.
Published: May 2023

Fahrs syndrome is a rare anatomoclinical entity whose main etiology is primary or postoperative hypoparathyroidism. It is characterized by bilateral and symmetrical intracerebral calcifications, localized in the basal ganglia. Hypoparathyroidism, primary or postoperative, is the most classic anomaly. Hyperparathyroidism is exceptionally reported as a cause of Fahr syndrome. We report the case of a 30-year-old woman who presented with an inaugural convulsive seizure revealing Fahrs syndrome secondary to iatrogenic hyperparathyroidism.
SEVERE DIABETIC KETOACIDOSIS WITH AN ACUTE MEDIASTINITIS COMPLICATING A FUNGALBRONCHOPNEUMONIA: A PEDIATRIC CASE
Authors:   Pediatric Intensive Care Unit, Anesthesiology-Intensive Care Medicine Department, Abderrahim El Harrouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco., Erragh A. , Bellaftouh S. ,   Pediatric Intensive Care Unit, Anesthesiology-Intensive Care Medicine Department, Abderrahim El Harrouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco., Afif A. ,   Pediatric Intensive Care Unit, Anesthesiology-Intensive Care Medicine Department, Abderrahim El Harrouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco., El Fakhr K. ,   Pediatric Intensive Care Unit, Anesthesiology-Intensive Care Medicine Department, Abderrahim El Harrouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco., Ouissal A. ,   Pediatric Intensive Care Unit, Anesthesiology-Intensive Care Medicine Department, Abderrahim El Harrouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco., Kalouch S. ,   Pediatric Intensive Care Unit, Anesthesiology-Intensive Care Medicine Department, Abderrahim El Harrouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco., Chlilek A. ,   Pediatric Intensive Care Unit, Anesthesiology-Intensive Care Medicine Department, Abderrahim El Harrouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco.
Published: May 2023

Introduction:Type 1 diabetes mellitus (T1DM) is the most common metabolic disorder occurring in childhood with significant morbimortality. Uncontrolled diabetic patients are exposed to fatal hyperglycemic emergencies such as Diabetic ketoacidosis (DKA) characterized by hyperglycemia, acidosis, and ketosis. Although infections remain the predominant precipitating factors for (DKA), its association with mediastinitis is, to date, a rare situation. The objective of this study was to bring the importance of diagnosing the underlying etiological precipitants during DKA to enhance the management of this complication and reduce its mortality. Case Description:The authors report during this article the case of a 7-year-old male patient, known type 1 diabetic on insulin therapy for 3 years, admitted to the pediatric intensive care unit in AbderrahimHarrouchi hospital in Casablanca for severe diabetic ketoacidosis with febrile reparatory distress and whom the non-improvement of the symptomatology leads us to diagnose an acute mediastinitis complicating its fungal bronchopneumonia. Discussion:This report will review the precipitant factors, relayed by literature, associated with acute metabolic decompensation of diabetes in pediatric patients and the incidence of fungal lung infection in the diabetic population.The authors also highlight the lack of scientific data concerning the mediastinitis complicating pulmonary infections, especially in the pediatric population. Conclusion:Acute mediastinitis is a serious medical condition, commonly misdiagnosed due to the polymorphic and unspecific clinical presentation that can be related to the bronchopneumonia itself. This fatal complication being an etiological factor of a DKA considerably increases its mortality.
THE DETERMINANTS OF SHORTER TIME TAKEN TO REACH FULL FEED AMONG EXTREMELY LOW BIRTH WEIGHT NEWBORNS ADMITTED TO LEVEL III NEONATAL INTENSIVE CARE UNIT OF GOVERNMENT HOSPITAL
Authors:   Junior Resident -3 at Pediatric Department of BJGMC and Sassoon Hospital, Pune, Maharashtra., Uddhav Kale Manesh , Deshmukh Isha ,   Lecturer at the Pediatric Department of BJGMC and Sassoon Hospital, Pune, Maharashtra., Kinikar Aarti ,   Professor and Head of Department of Pediatric, BJGMC and Sassoon Hospital, Pune, Maharashtra., Valvi Chhaya ,   Associate Professor, Department of Pediatric, BJGMC and Sassoon Hospital, Pune, Maharashtra., Dawre Rahul ,   Assistant Professor, Department of Pediatric, BJGMC and Sassoon Hospital, Pune, Maharashtra.
Published: May 2023

Background: Although extremely low gestational age newborns (ELGANs) or extremely low birth weight (ELBW)newborns are born they have their third-trimester intrauterine life pertaining to development. During this time, one of the objectives of the NICU staff is to feed the newborn with enough nourishment to reach a growth velocity (GV) comparable to intrauterine GV. Early parenteral & enteral nutrition to ELBW infants during the first twenty-four hrs of life leads to a quick recovery of weight loss, enhanced overall weight growth, and earlier accomplishment of complete enteral feeding. Early & substantial protein administration has also been linked to increased weight gain & brain growth. Aims/Objective: To identify determinants of shorter time taken to reach full feeds among ELBW admitted to level III NICU. Method: It was a retrospective hospital-based study conducted from April 2022 to September 2022 and included 55 ELBW newborns admitted to NICU satisfying the WHO definition of ELBW and categorizedinto group I(<28wks), group II (>28 wks. till 31 wks.). Various determinants like ventilatory support, surfactant therapy, NEC, gestational age (GA), etc. are used for analysis. Results: 55 ELBW analysed their mean gestational age (27Â±3.1) weeks, Range (25-31 weeks) Mean Birth weight (884Â±114 gram) Range (500-<1000 gm). There were 2 groups, Group 1 (< 28 weeks) included 28 ELBW who reached full feeding in 16.8Â±13.8 days whereas 27 ELBW were included in Group 2 who reached full feeding in 13.07Â±8.5 days. Most of the determinates have P VALUE-0.0 except birth weight(P-0.89) and metabolic factor (P-0.14). Overall, all determinates have an impact the on duration to reach full feed in ELBW. Conclusion: ELBW newborns who require minimal ventilatory support, no surfactant, less association with NEC, IVH, Sepsis, and average gestation age above 28 weeks attained early full feed regain birth weight also decreases hospital stay. Funding source: None. Ethics committee clearance submitted Conflict of interest: None.
SINGLE RIB METASTASIS OF THYROID FOLLICULAR CARCINOMA: ABOUT02 CASES
Authors:   Thoracic Surgery Department, University Hospital Mohammed VI, Marrakech, Morocco., El Harich Walid , Cedric Bayem Joel ,   Thoracic Surgery Department, University Hospital Mohammed VI, Marrakech, Morocco., Kelly Haag Edwin ,   Medical Oncology Department, University Hospital Mohammed VI, Marrakech, Morocco., Fenane Hicham ,   Thoracic Surgery Department, University Hospital Mohammed VI, Marrakech, Morocco., Msougar Yassine ,   Thoracic Surgery Department, University Hospital Mohammed VI, Marrakech, Morocco.
Published: May 2023

Follicular carcinoma is the second most common histological type of thyroid carcinoma and has a particular tropism for the bone. However, costal metastases remain rare events. We report two cases of unique costal metastases, the first of which is indicative and the second a late recurrence of thyroid follicular carcinoma. We performed in both cases a complete removal with parietal reconstruction followed by radioiodine therapy. No recurrences were recorded after 06 months of follow-up. This demonstrates the importance of surgery in the management of oligometastases during follicular thyroid carcinomas for better long-term results.
ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF STAPHYLOCOCCUS AUREUS ISOLATED FROM VARIOUS CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL
Authors:   DepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad431003(Maharashtra)India., A. Lokhande Ajay , S. Wyawahare Anupama ,   DepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad431003(Maharashtra)India., J.K. Mishra ,   DepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad431003(Maharashtra)India., M.V Mulay ,   DepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad431003(Maharashtra)India.
Published: May 2023

Background: Staphylococcusaureusisanosocomialpathogen,causinghighmorbidityandmortality.TheprevalenceofMRSAinfectionandthesusceptibilitypatternofStaphylococcusaureusvarieswiththeregion. WiththisbackgroundpresentstudywasundertakentodeterminetheprevalenceofstaphylococcusaureusandMethicillin-ResistantStaphylococcusaureus(MRSA)isolatesfromvariousclinicalsamplesandtheirantimicrobialsusceptibilitypatterninatertiarycarehospital. MaterialsandMethods: Inthisretrospectivestudy,atotalof240isolatesofStaphylococcusaureuswascollectedfromaclinicalspecimen,betweenJune2021toMay2022intheDepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad.StaphylococcusaureuswasidentifiedandtheirantibioticsusceptibilitytestingwasdeterminedbyusingVitek2compactsystemanddatawereanalyzed. Result: Inourstudytotalof240StaphylococcusaureuswereisolatedandtheprevalenceofMSSAwas27.5%andtheprevalenceofMRSAwas72.5%fromvariousclinicalsamples. Outof240Staphylococcusaureusisolates,116(48.33%)wereresistanttoBenzylpenicillin,followedbyCiprofloxacin212(88.33%),Levofloxacin212(88.33%),Erythromycin154(64.17%),Clindamycin122(50.83%),Trimethoprim/Sulfamethoxazole120(50.00%),Gentamicin56(23.33%),Rifampicin15(6.25%)andTigecycline6(2.50%). Conclusion: AhighprevalenceofMRSA(72.50%)wasobservedinourregion.ThemosteffectiveantibioticsforthetreatmentofMRSAwereLinezolid,Vancomycin,Teicoplanin,andTetracycline.TheseantibioticsshouldbekeptreservedforthetreatmentofMRSAinfection. Regularsurveillanceofhospital-associatedinfectionsisrequiredforassessingthetrendsintheantibioticresistanceofpathogensforstrengtheningthecontrolmeasurestopreventthespreadandreducetheemergenceofmultidrug-resistantMRSAinfections.
A STUDY OF CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) & TUMOR NECROSIS FACTOR - IN POST MENOPAUSAL KNEE OSTEOARTHRITIC FEMALE PATIENT.
Authors: Chauhan Barkha
Published: May 2023

Osteoarthritis is a type of arthritis that occurs when the flexible ends of tissues at the end of the bones wear down and it could be due to various causes affecting the daily life of the people. Women are the most important part of society and according to studies it was stated women are more affected than men. There are many biochemical markers involved in the diagnosis of osteoarthritis with other investigations like radiological, and clinical approaches. Here in this study the Cartilage oligomeric matrix protein (COMP) and Tumor necrosis factor Ã‚Â– alpha (TNF-?) were determined in post-menopausal knee osteoarthritic female patients and normal healthy subjects taking into consideration of all the exclusion and inclusion criteria. The samples were collected and tests were performed by ELISA. The study suggested that raised levels of the serum COMP & TNF-? in the study group were age-related changes with inflammation and infection at the knee joint which were suggestive of knee osteoarthritis.
NUTRITION ADEQUACY OF ETERNAL NUTRITIONAL SUPPORT IN CRITICALLY ILL PATIENT AT KING ABDULAZIZ HOSPITAL AL-AHSA
Authors:   Clinical Nutrition Department., Mariam Bi Bi , Obeidat Bayan ,   College of Applied Medical Sciences-Al Ahsa, Female Branch., Shehri Awad ,   King Saud bin Abdulaziz University for Health Sciences., Alsaqer Nouf ,   Kingdom of Saudi Arabia., Almulhim Lama ,   Clinical Nutrition Department., Busbait Maha ,   College of Applied Medical Sciences-Al Ahsa, Female Branch., AlMulhim Mariam ,   King Saud bin Abdulaziz University for Health Sciences., AlMulhim Taif ,   Kingdom of Saudi Arabia.
Published: May 2023

Background: This study was to determine the adequacy of nutritional support by assessing energy and protein intake for the first four days after initiation of enteral nutrition among critically ill patients. Methods: The prospective, cross sectional study carried out in a medical intensive care unit in King Abdulaziz hospital Al Ahsa from September 2020 to November 2020. 130 patients were enrolled. Patients were scheduled to receive their ordered enteral nutritional requirements. Their intake was compared with their requirement based on ASPEN guidelines for critically ill patients. Results: Majority of respondents were (54.5%) in the age group of 50 to 75 years, males with mean height of 163.9(Â± 7.098)cms and weight of 69.87 (Â± 8.862). Infection, wound, and Sepsis were major metabolic stressor with high number of respondents were having cancer (49.2%), PEG tube was inserted (64.4 %), During the first 4 days of tube insertion, the mean intake of calories and fluid (1432.31Â±176.24 versus 1704 Â±175.01 k.cal p< .05) and fluid(1432.31Â±176.24 versus 1704 Â±175.01 ml p< .05) was statistically lower and protein (117.99 +/- 18.05 g versus 87.98 +/- 22.14 g p < .05) fat (66.25Â±16.25 versus 56.82 Â±5.83 g, p< .05) was statistically greater for patients. Carbohydrate was (121.04Â±40.96 versus 180.32 Â±27.07 g, p> .05) is statistically non-significant Conclusions: The study result showed that under feeding was seen for energy and fluid among critically ill ICU patients and overfeeding was seen for protein, and fat. It is important to correct enteral nutrition intervention because that will help in tolerability of eternal feeding, duration of stay, economic burden on individuals and societies.
TRAUMATIC GASTROINTESTINAL INJURIES: AN OVERVIEW OF CLINICAL PROFILE, MODE AND SITE OF INJURIES
Authors:   Professor, Department Of Surgery, GMC Srinagar, J&K., Mushtaq Ahmad Shah Syed , Hussain Beigh Anwar ,   Post Graduate Scholar, Department Of Surgery, GMC Srinagar, J&K., Bashir Haris ,   Senior Resident, Department Of Surgery, GMC Srinagar, J&K., Iqbal Mohammad ,   Senior Resident, Department Of Surgery, GMC Srinagar, J&K., Shafi Salroo Asim ,   Post Graduate Scholar, Department Of Surgery, GMC Srinagar, J&K.
Published: May 2023

Introduction:Trauma has become the major health care challenge, with abdomen being the third most commonly involved region of the body. Gastrointestinal tract injuries require prompt attention owing to potential for sepsis, caused either by blunt or penetrating injuries. Blunt trauma usually affects solid organs while as penetrating trauma mostly affects Gastrointestinal tract, commonly ileum, jejunum, colon, etc Material and methods: The patients with traumatic gastrointestinal perforation resulting from both blunt as well as penetrating trauma, were identified based on clinical presentation like pain abdomen, vomiting, fever, distension of abdomen, tenderness and supportive radiological evidences. The patients were examined and resuscitated and data was collected and organized according to the following categories: age, gender, clinical presentation, mode of trauma, duration of injury prior to admission/ presentation, radiological assessment, diagnosis, anatomical location. Results: Maximum patients were found to be in the age group of 21-40 years, with male preponderance. RTA (50%) was the most common mode of trauma, with Ileum (61.36%) being the most commonly involved site of GI tract. Conclusion:Traumatic GIT injuries is on the rise, mainly among young males with RTA being the most common mode of trauma.
CROP GROWTH MONITORING SYSTEM BASED ON DRONE AND LOW POWER WAN
Authors: a Ayouziayoub , LI Jingzhao
Published: May 2023

Smart farming is currently seen as an effective way to increase farm productivity and has gained a lot of attention from service providers. It offers a variety of applications, from identifying pests to monitoring assets. The emergence of digital technologies such as IoT and LPWANs has improved the smart farming industry, but more efficient solutions are still needed. Unmanned aerial vehicles, or drones, are increasingly being used across various civil domains, and this paper aims to create a farm monitor-ing system that combines UAVs, LPWANs, and IoT technologies. This system aims to revolutionize current farm management practices and provide farmers with valuable data for their operations. To ensure the quality of soil in farming development, a system for monitoring soil quality using IoT technology was created. The collected data from the sensors was transmitted to the cloud for analysis through a multi-channel LoRaWANÂ® gateway integrated into a drone that uses dynamice mode. Various simulations and measurements were done to develop aerial communication based on LoRaWANÂ®, and the UAV path planning was optimized to improve the efficiency of data collection.
TRIPLE MARKERS (ER, PR, HER 2 NEU) AND THEIR RELATIONSHIP WITH KI67 EXPRESSION IN BREAST CARCINOMA - AN OBSERVATIONAL STUDYIN NORTH EAST INDIA
Authors:   Post Graduate Resident, 3rd year, Deptt. Of Pathology, AGMC & GBP Hospital, Tripura., Saha Diya , Bhattacharjee Kulashekhar ,   Associate Professor, Deptt. Of Pathology, AGMC & GBP Hospital, Tripura., Saha Bhowmik Rajen ,   Post Graduate Trainee, Deptt. of Medicine, AGMC & GBP Hospital, Tripura., Chaudhuri Diptendu ,   Assistant Professor, Deptt. Of Surgery, AGMC & GBP Hospital, Tripura., Datta Abhijit ,   Professor & HOD, Deptt. Of Pathology, AGMC & GBP Hospital, Tripura.
Published: May 2023

Background:Breast cancer is the most common and deadly malignancy of women globally. Breast cancer is called ER/PR positive if it has receptors for hormone estrogen/progesterone. Similarly HER2neu positive status of breast carcinoma means that HER2neu gene is making too many HER2neu proteins. Hormone receptor studies with ER, PR & HER2neu are routinely done in breast carcinoma. Ki67 is an independent factor to predict tumour grade. Breast carcinoma can therefore be classified based on expression patterns of ER, PR, HER2neu & correlated with Ki67 into various molecular subtypes. Objectives:(1) To determine the association between expression patterns of ER, PR and HER2neu with Ki67 in breast carcinoma in patients attending our hospital. (2) To estimate the proportion of different molecular subtypes of breast carcinoma. Materials & Methods: It was an observational cross sectional study done on 122 cases for a period of 2 years(July 2020- June 2022) and surgical specimens from patients operated for breast carcinoma of all ages along with true cut biopsies were included. Immunohistochemical study for ER, PR, HER2Neu & Ki67 were performed on breast tissue specimens received. Results:The study found inverse correlation of Ki67 with ER, PR and its direct correlation with Her2Neu. TNBC (Triple Negative Breast Carcinoma) was the most predominant molecular subtype. Conclusion:High Ki67 is considered as an unfavourable factor influencing tumour progression and is associated with poor prognosis. Ki67 is a potential prognostic biomarker in breast cancers and such prognostic information could be beneficial for development of therapeutic strategy.
CONDUTA DOS CIRURGIÕES-DENTISTAS FRENTE À VIOLÊNCIA CONTRA A MULHER: UMA REVISÃO INTEGRATIVA
Authors: Coelho do Nascimento Sabrina Paula , Souza Barreto Talyta , Vieira Simões Aline , Alves Paz de Carvalho Cristiane , Silva de Carvalho Fábio
Published: May 2023

Introdução: A violência doméstica, uma problemática constante na vida de muitas mulheres, possui dimensões globais. Esse infortúnio que assombra o sistema de saúde se intensificou ainda mais com as medidas de restrição social e o confinamento das vítimas com seus agressores por um longo período, no cenário de pandemia da Covid-19. Nesse sentido, é relevante falar sobre o acompanhamento multiprofissional, que deve ser garantido pelo Estado, e sobre as lesões provocadas pelos maus-tratos, sobretudo na face, que interferem na identidade visual, autoestima e qualidade de vida, acarretando desordens físicas e psicológicas na mulher. Objetivo: Essa pesquisa teve por objetivo identificar a conduta dos cirurgiões-dentistas frente à violência contra a mulher, por meio de uma revisão integrativa. Metodologia: A busca dos estudos foi realizada nas plataformas de bancos de dados da Biblioteca Virtual de Saúde (BVS) e da National Library of Medicine (PubMed). Foram selecionados os textos completos, disponíveis em português, referentes aos últimos cinco anos (2017-2022) e utilizando os descritores "Violência contra as mulheres", “Saúde bucal”, "Autoimagem" e “Traumatismos da Face”. Em inglês na PubMed e português na BVS, combinados com o operador booleano “AND”. Resultados: Foram recuperados 51 estudos, dos quais utilizaram-se 13, pois esses satisfizeram os critérios de inclusão e exclusão, demonstrando que o tema de maior destaque foi a violência contra a mulher associada com a autoestima, autoimagem e predominantemente estudos transversais. Ainda, os dados encontrados não contemplaram completamente a indagação sobre o papel do cirurgião-dentista diante do acolhimento das vítimas da violência doméstica Conclusões: Os cirurgiões-dentistas como profissionais de saúde, inseridos diariamente no manejo das lesões de cabeça e pescoço, fazem parte do acolhimento das vítimas de violência doméstica e devem ser capacitados para lidar com as demandas necessárias.
SAÚDE BUCAL NA PRÁTICA DO CANTOR LÍRICO
Authors: da Silva Tatiane Cristina Santos , Ramos Hosana Souza Neves , De Souza Dione Colares , Colares Geovana Freitas , Da Silveira Ana Daniela Silva
Published: May 2023

Introdução: Para que haja qualidade na emissão vocal, é necessária alta compreensão em relação aos conhecimentos específicos e cuidados com o sistema fisiológico da voz. Destacando-se a anatomia corporal e os mecanismos pneumofonoarticulatórios, que envolvem respiração, fonação e articulação. Objetivo: O objetivo da pesquisa foi analisar a autopercepção de cantores quanto a sua saúde bucal e com a sua própria fala; e se a saúde bucal interfere na prática do cantor lírico. Metodologia: Texto do método. Para a realização desta pesquisa, foi enviado por e-mail o link do questionário on-line a cantores líricos, de várias localidades, com a faixa etária entre 18 a 51 anos. Os dados foram analisados utilizando a estatística analítica e descritiva com o parâmetro do poder de teste de 95% e o erro α de 5%. Resultados: Os resultados indicam que 34,3% dos cantores líricos estão insatisfeitos com a saúde bucal, 62,5% identificou que possui pelo menos uma das condições ou alterações de saúde bucal citadas no questionário. Conclusões: O tratamento ortodôntico ou uso de prótese foram relatados como fatores que prejudicam o desempenho vocal.
Russia’s participation in economic globalization: new reversal of tendencies
Authors: Bulatov A. S.
Published: May 2023

The article analyzes the most important shifts in the indicators of globalization of the world economy. The author attempts to give a retrospective analysis of Russia's participation in international trade, the movement of capital, labor, knowledge and its monetary and settlement relations with the outside world over the past 3 decades. The author comes to the conclusion that the globalization of the Russian economy in the last 3 decades has brought the country a lot of wins and losses, the balance of which was formed in different ways. But 2022 became after the mid-1990s. another turning point in this process and, along with positive changes (acceleration of import substitution), this turning point carries threats, first of all, a reduction in the inflow of knowledge and capital. The turning point in the globalization of the Russian economy that has emerged in recent years and occurred in 2022 is caused mainly by political, not economic reasons.
Agriculture export policy in India: 2010-2020-ies
Authors: Deryugina I. V
Published: May 2023

The increase in exports of agricultural and food products from India to the world market gave an impetus to the author to study the measures of the country's agricultural export policy. The transition to an export-oriented development model announced at the end of the twentieth century led to the development of new approaches to foreign trade policy. Export promotion measures in the field of agriculture were prepared taking into account the peculiarities of agri-cultural production in India and were of a systematic nature. They included: political mecha-nisms, in particular the involvement of state governments; infrastructure and logistical support; economic stimulation of exports, including the creation of special export zones (agricultural clusters), attracting private investment in production and processing. Important attention was paid to the organization of the electronic National Agricultural Market (E-NAM), the digital platform of the Agri Exchange APEDA, the modernization of seaports intended for the export of agricultural goods. The result of the agrarian policy was two points – an increase in the growth rate of agricultural production and an increase in agricultural exports. The volume of exports of agricultural goods has more than tripled over the past decade and a half, and the export basket of these goods has significantly expanded. India has become the world's leading rice exporter, has become one of the world market leaders in exporting such non-traditional goods for the country as fish and aquaculture products, meat, milk and dairy products, and has also retained its traditional cotton and sugar markets.
Development of chinese-brazilian agri-food trade
Authors: Ivanova S. V. , Aleksandrov I. O.
Published: May 2023

The article analyzes the Chinese-Brazilian trade in agri-food products. The importance and complementarity of bilateral trade flows are revealed; Brazil's growing inter- and intra-industry specialization in the supply of agricultural raw materials while maintaining a negative balance for the Chinese side. There was a significant lag between the net exporter and the importer in terms of the global food security index and the presence of a higher prevalence of malnutrition among the population. The decline in the already low share of agri-food products in total exports from China to Brazil is determined by the growth of domestic consumption of a variety of food products of domestic production and China's international specialization in the field of non-agricultural products with medium and high levels of added value. The main changes in tariff and non-tariff measures for regulating mutual trade have been identified. Emphasis is placed on the relationship between investment and trade policy of China, whose companies invest in the agro-industrial complex and infrastructure of Brazil in various forms, including international business mergers and acquisitions, construction from scratch, creation of joint ventures. The factors, risks and prospects of further development of the Sino-Brazilian agricultural trade are identified, taking into account the geopolitical effects of the possible substitution of large-scale purchases of soybeans from the United States with Brazilian supplies to China.
Fixed monetary regimes – debates and arguments
Authors: Nenovsky N. , Faudot A.
Published: May 2023

The paper examines the main arguments defending and rejecting fixed exchange rate regimes. It argues that, contrary to what is claimed and in line with practice, these types of regimes have more advantages than disadvantages. They make trade and international coordination significantly more efficient and predictable. Many of the arguments about the loss of degrees of freedom in monetary and macroeconomic policy-making, and the loss of sovereignty, need to be relativised. This is done in this first part of the paper. In the second part, to be published in the next issue, we present different institutional forms that can overcome the problems surrounding fixed exchange rates in different ways, namely currency boards and dollarization, capital controls, and different models of clearing unions.
Formulation, Evaluation and Optimization of Antimicrobial Potential of Herbal Cream Containing Allium sativum, Moringa oleifera Extracts and Thymus vulgaris Oil
Authors: Sheikh Maliha , Khan Humaira M. , Khan Muhammad U.Z. , Sharif Ali
Published: May 2023

Background:

Herbal preparations can be formed by combining several plant classes. One possible explanation for the effectiveness of combined medications is that the various mixtures with different mechanisms may add up to produce a more comprehensive therapeutic effect.

Objective:

This study aims to investigate the synergistic antibiotic potential of a cream containing three natural herbal extracts: Allium sativum, Moringa oleifera, and Thymus vulgaris. The efficacy of combining these plant extracts was compared to that of a standard antibiotic formulation (Polyfax).

Methods:

The herbal cream was formulated by using aqueous extracts of garlic (Allium sativum), moringa (Moringa oleifera) and essential oil of thyme (Thymus vulgaris). The study aimed to explore the therapeutic potential of these extracts against bacteria. P. aeruginosa, B. subtilis, E. coli, S. aureus, and S. pneumonia are commonly found in fresh wounds.

Results:

The results showed that garlic extract (5%) had the highest zone of inhibition, 14.26 ± 0.05 mm, and a combination of garlic (5%) and thyme (2%) exhibited a significant synergistic effect, with a 23.5 ± 0.05 mm zone of inhibition. High-performance liquid chromatography analysis revealed the presence of allicin, quercetin and thymol as potential therapeutic phytoconstituents. The formulated herbal cream had a soft texture, was easily spreadable, and had better stability and absorption than the standard polyfax. The topical application of the cream did not cause any skin reaction or allergy in mice. The in vivo wound healing effect of the herbal cream was investigated on an abrasion model of albino mice, and the results showed that the treatment group (46 ± 16.31%) had significant wound healing potential compared to the standard (64 ± 17.49%) and control groups (18 ± 3.74%).

Conclusion:

The formulated herbal cream was a better alternative to standard therapy, exhibiting promising healing and antimicrobial effects with significant compatibility and safety profile.
Synthesis and Characterization of Novel 4-aryl-4H-chromene Derivatives using Borax and Evaluation of their Anticancer Effects
Authors: Adibi Hadi , Hosseinzadeh Leila , Amirafshari Mahya , Jalilian Fereshteh
Published: May 2023

Background/Introduction:

4-aryl-4H-chromenes have attracted attention as potential anticancer agents.

Objective:

In an effort to discover effective compounds, we designed a new series of these chromenes with methoxy substitution at 2, 3, 4, 5, and 6 positions.

Methods:

The synthesized compounds were tested for anticancer properties against two human cancer cell lines (MCF- 7 and PC3) as well as a normal cell line. Furthermore, induction of apoptosis was explored through various methods, such as flow cytometry analysis, morphological changes, activation of caspase 3, ROS, and MMP.

Results:

The MTT assay showed that the 5g derivative, with methoxy groups at ortho and meta positions, exhibited the highest potency (IC50 = 40 μM) against the PC3 cell line. Our findings revealed that compound 5g induced apoptosis in the PC3 cell line, which was demonstrated by activation of caspase 3, an increase in ROS levels, and early apoptosis percentage.

Conclusion:

These results suggest that compound 5g holds promise as a potential therapeutic approach to cancer treatment.
Riboflavin and Histidine Metabolisms Are Two Key Pathways Related
to the Clinically Isolated Syndrome (CIS): A WGCNA-based In silico
Analysis
Authors: Afshar Parvaneh Tavakoli , Taherian Zohreh , Bakhtiyari Roya , Rami Farzaneh , Etemadifar Masoud , Salehi Mansoor
Published: May 2023

Background:

As an inflammatory disorder, Multiple Sclerosis (MS) causes demyelination,
as well as axonal and neuronal injury in the central nervous system (CNS).
Several clinical signs may be the indicators of MS among which, Clinically Isolated Syndrome
(CIS) is the first symptom caused by the inflammation and demyelination of CNS.
CIS is characterized by symptoms such as optic neuritis, brain stem or cerebellar syndrome,
spinal cord syndrome, or sometimes cerebral hemispheric dysfunction.

Objective:

So far, metabolic pathways involved in the development of CIS are not fully understood.
Therefore, in this study, weighted gene co-expression network analysis (WGCNA)
has been used to identify differentially expressed genes in CIS disease and the main
pathways associated with it.

Methods:

We grouped differentially expressed genes along with the functionally related
genes into large modules to obtain their direct and indirect relationships.

Results:

The results have identified two new pathways associated with CIS, including riboflavin
and histidine metabolism-involved pathways.

Conclusion:

Riboflavin and histidine metabolism-involved pathways may be considered
potential therapeutic goals for CIS management in the future.