bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors associated with anti-SARS-CoV-2 antibody titres 3 months post-vaccination with the second dose of BNT162b2 vaccine: a longitudinal observational cohort study in western Greece
Authors: Parthymou Anastasia , Habeos Evagelia E , Habeos George I , Deligakis Apostolos , Livieratos Ektoras , Marangos Markos , Chartoumpekis Dionysios V
Published: November 2022

Objectives

Vaccination against SARS-CoV-2 has been extensively deployed during COVID-19 pandemic. One efficient method to evaluate response to vaccination is the assessment of humoral immunity by measuring SARS-CoV-2 antibody titres. We investigated the association between anthropometric parameters (age, body mass index), smoking, diabetes, statin use, hypertension, levels of 25(OH)D and dehydroepiandrosterone sulfate (DHEAS), and SARS-CoV-2 antibody titres after vaccination.

Design

In this longitudinal observational cohort study, 712 subjects were tested for SARS-CoV-2 antibodies 3 months after the second dose of BNT162b2 vaccine. Multiple linear regression analysis was performed to identify which factors are associated with the antibody titres.

Setting

Healthcare units of western Greece (University Hospital of Patras and “St Andrews” State General Hospital of Patras).

Participants

All adults receiving their second dose of BNT162b2 vaccine at the participating healthcare units were eligible to participate in the study. Exclusion criteria were SARS-CoV-2 infection or positive SARS-CoV-2 antibody titre at baseline. Patients who did not provide all necessary information were excluded from our analyses.

Results

We found age to be negatively associated with antibody titre (−0.005; 95% CI −0.009 to −0.001, p=0.0073), as was male gender (−0.11; 95% CI −0.1738 to −0.04617, p=0.0008). The interaction of age and gender was significant (−0.01090; 95% CI −0.01631 to −0.005490, p<0.0001), highlighting that the rate of decline in antibody titre with increasing age tends to be higher in men rather than in women. No linear trend was found between DHEAS levels and antibody titres when the lower quartile of DHEAS levels was used as reference. Tobacco use was associated with low antibody titre (−0.1097; 95% CI −0.174 to −0.046, p=0.0008) but overweight, obese or underweight subjects had similar antibody responses to normal-weight individuals. Although subjects with diabetes and hypertension had numerically lower antibody titres, this association was not statistically significant. Vitamin D levels showed no clear relationships with antibody titres.

Conclusions

Age, male gender and tobacco use are negatively associated with antibody titres after COVID-19 vaccination, but our data showed no clear correlation with vitamin D levels.

Trial registration number

NCT04954651; Results.
Severe COVID-19 anxiety among adults in the UK: protocol for a cohort study and nested feasibility trial of modified cognitive–behavioural therapy for health anxiety
Authors: Crawford Mike J , Leeson Verity C , McQuaid Aisling , Samuel Oluwaseun , King Jacob D , Di Simplicio Martina , Tyrer Peter , Tyrer Helen , Watt Richard G , Barnicot Kirsten
Published: November 2022

Introduction

Some people are so anxious about COVID-19 that it impairs their functioning. However, little is known about the course of severe COVID-19 anxiety or what can be done to help people who experience it.

Methods and analysis

Cohort study with a nested feasibility trial with follow-up at 3 and 6 months. We recruited 306 people who were aged 18 and over, lived in the UK and had severe COVID-19 anxiety (indicated by a score of 9 or more on the Coronavirus Anxiety Scale (CAS)). To take part in the nested feasibility trial, participants also had to have a score of 20 or more on the Short Health Anxiety Inventory. We excluded people from the trial if they had had COVID-19 within the previous 4 weeks, if they were currently self-isolating or if they were already receiving psychological treatment.

We publicised the study nationally through adverts, social media and posts on message boards. We also recruited participants via clinicians working in primary and secondary care NHS services in London. All those in the active arm will be offered 5–10 sessions of remotely delivered modified cognitive–behavioural therapy for health anxiety (CBT-HA). We will examine the proportion of participants who remain above threshold on the CAS at 3 and 6 months and factors that influence levels of COVID-19 anxiety over 6 months using mixed effects logistic regression. The key feasibility metrics for the nested trial are the level of uptake of CBT-HA and the rate of follow-up.

Ethics and dissemination

Approved by Leicester Central Research Ethics Committee (reference: 20/EM/0238). The results of the study will be published in peer-reviewed scientific journals.

Trial registration number

NCT14973494.
Exploration of the impact of gene therapy on the lives of people with haemophilia and their families: a protocol for the mixed-methods exigency study
Authors: Fletcher Simon , Pembroke Luke , Holland Mike , Khair Kate
Published: November 2022

Introduction

Gene therapy has the potential to change the life experience of people with haemophilia and their families. A growing number of studies have examined the experience for those who have had gene therapy. A few studies have examined the process with other gene therapy among a wider cross-section of the haemophilia community.

Exigency is a nested group of studies investigating the experience and understanding of the haemophilia community to identify what place gene therapy is likely to have in haemophilia care.

Five groups have been identified: those who have already undergone gene therapy, those who do not want it, those who wanted to have it but withdrew or were withdrawn before dosing, those who have not yet been offered it and parents of children with haemophilia.

Methods

A qualitative, mixed-methods process will identify what each group understands about gene therapy and what it might mean for the haemophilia community in the future.

Analysis

All of the transcripts will be analysed by the lead and coinvestigator using a grounded theory approach. The texts will be coded into themes for further analysis. The data will be summarised and synthesised, and the views expressed will be represented descriptively.

Ethics and dissemination

Written consent will be required, and participants will be anonymised. All elements of the study will be reviewed by UK statutory bodies.

The study findings will be submitted for publication in peer-reviewed journals, and at haemophilia conferences and symposia.

The study results will also be disseminated directly to study participants. Each participant will receive a copy of any publication and a summary report at the end of the study.

Trial registration number

NCT04723680
LOng COvid Multidisciplinary consortium Optimising Treatments and servIces acrOss the NHS (LOCOMOTION): protocol for a mixed-methods study in the UK
Authors: Sivan Manoj , Greenhalgh Trisha , Darbyshire Julie Lorraine , Mir Ghazala , O'Connor Rory J , Dawes Helen , Greenwood Darren , O’Connor Daryl , Horton Mike , Petrou Stavros , de Lusignan Simon , Curcin Vasa , Mayer Erik , Casson Alexander , Milne Ruairidh , Rayner Clare , Smith Nikki , Parkin Amy , Preston Nick , Delaney Brendan
Published: November 2022

Introduction

Long COVID, a new condition whose origins and natural history are not yet fully established, currently affects 1.5 million people in the UK. Most do not have access to specialist long COVID services. We seek to optimise long COVID care both within and outside specialist clinics, including improving access, reducing inequalities, helping self-management and providing guidance and decision support for primary care. We aim to establish a ‘gold standard’ of care by systematically analysing current practices, iteratively improving pathways and systems of care.

Methods and analysis

This mixed-methods, multisite study is informed by the principles of applied health services research, quality improvement, co-design, outcome measurement and learning health systems. It was developed in close partnership with patients (whose stated priorities are prompt clinical assessment; evidence-based advice and treatment and help with returning to work and other roles) and with front-line clinicians. Workstreams and tasks to optimise assessment, treatment and monitoring are based in three contrasting settings: workstream 1 (qualitative research, up to 100 participants), specialist management in 10 long COVID clinics across the UK, via a quality improvement collaborative, experience-based co-design and targeted efforts to reduce inequalities of access, return to work and peer support; workstream 2 (quantitative research, up to 5000 participants), patient self-management at home, technology-supported monitoring and validation of condition-specific outcome measures and workstream 3 (quantitative research, up to 5000 participants), generalist management in primary care, harnessing electronic record data to study population phenotypes and develop evidence-based decision support, referral pathways and analysis of costs. Study governance includes an active patient advisory group.

Ethics and dissemination

LOng COvid Multidisciplinary consortium Optimising Treatments and servIces acrOss the NHS study is sponsored by the University of Leeds and approved by Yorkshire & The Humber—Bradford Leeds Research Ethics Committee (ref: 21/YH/0276). Participants will provide informed consent. Dissemination plans include academic and lay publications, and partnerships with national and regional policymakers.

Trial registration number

NCT05057260,NCT15022307.
Exploring challenges to nutrition intervention adherence using COM-B model among patients with wet age-related macular degeneration: a qualitative study
Authors: Bian Wei , Wang Zonghua , Wan Junli , Zhang Feng , Wu Xuemei , Li Xin , Luo Yu
Published: November 2022

Objectives

To explore challenges to nutrition intervention adherence using the Capability, Opportunity and Motivation-Behaviour (COM-B) model among wet age-related macular degeneration (AMD) patients. These factors should be considered in the development of potential support and intervention programmes to address these problems.

Design

A qualitative study was conducted with one-to-one and face-to-face interviews with wet AMD patients using a semi-structured question guide. Data were analysed based on COM-B model: capability (physical and psychological), opportunity (physical and social) and motivation (reflective and automatic).

Setting

Southwest Hospital of Chongqing Province in China.

Participants

A convenient and purposive sample of 24 wet AMD patients were recruited.

Results

The themes and subthemes were identified: psychological capability: (1) insufficient knowledge of nutrition; (2) misconceptions about the disease and treatment; (3) knowledge conflict; physical capability: (1) physical restriction; (2) limited access to nutrition knowledge; physical opportunity: (1) communication between providers and patients; (2) health insurance and extra charges; (3) food environment; social opportunity: (1) stigma of disease; (2) family influence; reflective motivation: (1) self-efficacy; (2) attitude; (3) outcome expectancies; (4) lack of professional support; automatic motivation: (1) difficulties in changing eating habits; (2) mindset.

Conclusion

Medical staff should pay much attention to the process of patients’ nutrition intervention. In addition, it is also necessary to develop professional and internet-based intervention to modify the dietary behaviour and improve the management skills of the patients.
Multiple Criteria Decision Analysis Based on Ill-Known Pairwise Comparison Data
Authors: Inuiguchi Masahiro , Innan Shigeaki
Published: November 2022

The analytic hierarchy process (AHP) provides a systematic approach to the evaluation of alternatives based on pairwise comparison matrices (PCMs) under multiple criteria. As human evaluation is not always accurate and precise, each component of a PCM showing relative importance has been expressed by an interval or a fuzzy number. In this paper, we treat a PCM whose components are represented by twofold intervals. The twofold intervals are composed of inner and outer intervals showing the range of surely acceptable values and the complement of the range of surely unacceptable values for relative importance, respectively. One may apply a fuzzy AHP approach by building a trapezoidal fuzzy number from the inner and outer intervals. However, this approach does not always fit the given information. Because the twofold interval information ambiguously specifies the range of acceptable values for the relative importance. Then we appropriately translate this information into a set of intervals including the inner interval and included in the outer interval, assuming that the decision-maker evaluates the priority weights implicitly as intervals. We investigate the decision analysis based on the twofold interval PCM. Three conflict resolution methods are proposed for treating the inconsistency in the twofold interval PCM. Parametric methods for visualizing possible alternative orderings are proposed. Numerical examples are given to demonstrate the differences between the proposed approach and the previous approaches.
Two-Stage Intelligent DarkNet-SqueezeNet Architecture-Based Framework for Multiclass Rice Grain Variety Identification
Authors: Fatima Maryam , Khan Muhammad Attique , Sharif Muhammad , Alhaisoni Majed , Alqahtani Abdullah , Tariqe Usman , Kim Ye Jin , Chang Byoungchol
Published: November 2022

Image processing is an important domain for identifying various crop varieties. Due to the large amount of rice and its varieties, manually detecting its qualities is a very tedious and time-consuming task. In this work, we propose a two-stage deep learning framework for detecting and classifying multiclass rice grain varieties. A series of steps is included in the proposed framework. The first step is to perform preprocessing on the selected dataset. The second step involves selecting and fine-tuning pretrained deep models from Darknet19 and SqueezeNet. Transfer learning is used to train the fine-tuned models on the selected dataset. The 50% sample images are employed for the training and rest 50% are used for the testing. Features are extracted and fused using a maximum correlation-based approach. This approach improved the classification performance; however, redundant information has also been included. An improved butterfly optimization algorithm (BOA) is proposed, in the next step, for the selection of the best features that are finally classified using several machine learning classifiers. The experimental process was conducted on selected rice datasets that include five types of rice varieties and achieves a maximum accuracy of 100% that was improved than the recent method. The average accuracy of the proposed method is obtained at 99.2%, through confidence interval-based analysis that shows the significance of this work.
Aquaculture Prediction Model Based on Improved Water Quality Parameter Data Prediction Algorithm under the Background of Big Data
Authors: Jiang Yuan , Yan Fei
Published: November 2022

Computer science and technology under the background of big data are closely related to the development of modern agriculture. The application of information processing technology in aquaculture will promote the scientific development of aquaculture. The aquaculture water quality directly affects the effect of aquaculture. Therefore, on the basis of the dynamic monitoring model of water quality, the relevant factors affecting water quality were analyzed, and a prediction model of aquaculture water quality was constructed. Considering the complex relationship between dissolved oxygen and water quality, combined with principal component analysis, a PCA-BP (principal component analysis back propagation) water quality prediction model was proposed. The parameters of PCA-BP water quality prediction model were optimized by genetic algorithm, the threshold and weight of BP neural network were determined, and an improved PCA-BP water quality prediction model was constructed. The experimental results show that the relative error of the GPCA-BP water quality prediction model for the prediction of dissolved oxygen content is less than 0.76% in water quality prediction experiments in different times and regions, and it has the best prediction accuracy. At the same time, GPCA-BP water quality prediction model also has excellent performance in convergence accuracy, prediction accuracy, and MAE error performance test. The research content has important reference value for the application of information technology in modern aquaculture.
Regression of Left Ventricular Hypertrophy in Patients Combined with Peritoneal Dialysis and Hemodialysis
Authors: Luyan Gao , Haixia Zhang , Sheng Feng , Gang Sun , Jing Zhu , Ying Lu , Linsen Jiang , Kai Song , Zhi Wang , Huaying Shen
Published: November 2022

Background/Aims. Combined peritoneal dialysis and hemodialysis (PHD) are used in treating PD patients who underwent technique failure. This study aimed to research the cardiac structural and functional change in patients before and after PHD. Methods. This retrospective study enrolled 58 patients at The Second Affiliated Hospital of Soochow University who switched from PD to PHD. Clinical data and echocardiographic examination results were collected. Data from the two groups with a normal distribution were compared with the paired t-test. A

p

value <0.05 (two-tailed) was considered statistically significant. Results. A total of 58 subjects were enrolled, including 46 males and 12 females, with a median age of 50.2 ± 11.1 (47–68) years. The mean duration of peritoneal dialysis was 67.2 ± 33.6 months. Before and after PHD, the ultrafiltration volume (

p

 = 0.021) and hemoglobin (

p

 = 0.001) were increased, while SBP (

p

 = 0.002), DBP (

p

 = 0.002), phosphorus (

p

 < 0.001), and ESA dosage (

p

 < 0.001) were decreased. Before and after combined dialysis (PHD), the incidence of LVH was 76.4% and 61.8%, respectively (

p

 = 0.013), and LVMI decreased from 173.8 ± 86.2 g/m2 to 160.6 ± 78.5 g/m2 (

p

 < 0.001). Conclusion. Compared with PD alone, the combination of PD and HD resulted in regression of LVH and reduced LVMI.
A Model for Predicting Clinical Prognosis in Patients with WHO Grade 2 Glioma
Authors: Gao Qi , Zhou Huandi , Wang Guohui , Ma Zhenghui , Li Jiayuan , Wang Hong , Sun Guozhu , Xue Xiaoying
Published: November 2022

Objectives. Although patients with grade 2 glioma have a relatively better prognosis and longer survival than those with high-grade glioma, there are still a number of patients with disappointing outcomes. In order to accurately predict the prognosis of patients, relevant risk factors were included in the analysis to establish a clinical prediction model so as to provide a basis for clinically individualized treatment. Methods. A retrospective study was conducted in patients diagnosed with grade 2 glioma. Data including clinical features, pathological type, molecular classification, neuroimaging examination, treatment, and survival were collected. The data sets were randomly assigned, with 80% of the data used for model building and 20% for validation. Cox proportional hazard regression analysis was used to construct the model using important risk factors and present it in the form of a nomogram. The nomogram was evaluated a using C-index and calibration chart. Results. A total of 160 patients were enrolled in this analysis, including 128 in the training group and 32 in the validation group. In the training group, eight important risk factors including preoperative KPS, the first presenting symptom, the extent of resection, the gross tumor size, 1p19q, IDH, radiotherapy, and chemotherapy were identified to construct the model. The C-index of the training group and the validation group was 0.832 and 0.801, respectively, indicating that the model had good prediction ability. The calibration charts of the two groups were drawn respectively, which showed that the calibration line and the standard line had a good consistency, which suggested that the model-predicted risk had a good consistency with the actual risk. Conclusions. Based on the data of our center, a nomogram prediction model with eight variables has been established as an off-the-rack tool and verified its accuracy, which can guide clinical work and provide consultation for patients.
Mineral Composition and Full-Scale Pore Structure of Qianjiadian Sandstone-Type Uranium Deposits: Application for In Situ Leaching Mining
Authors: Wang Qizhi , Liang Xuanyu , Wang Wei , Niu Qinghe , Zhuo Jinyi , Su Xuebin , Zhou Genmao , Zhao Lixin , Li Po , Yuan Wei , Chang Jiangfang , Ji Zhongmin , Su Anye
Published: November 2022

In situ leaching (ISL) is becoming the main mining practice for sandstone-type uranium deposits in China. The key to ISL technology is to aid the leaching solution in contacting the ore bed over a large range, which will induce a series of chemical reactions to extract uranium; thus, it is essential to thoroughly understand the reservoir physical properties of uranium deposits. Taking the Qianjiadian sandstone-type uranium deposits (southern Songliao Basin, China) as an example, the mineral composition and pore structure of samples in different layers were measured using X-ray diffraction (XRD), thin section analysis (TSA), low-temperature N2 adsorption (LTN2A), and mercury intrusion porosimetry (MIP), and their influences on the ISL effect were analyzed. The results show that more than 65% of the minerals in the Qianjiadian uranium deposits are felsic minerals, and the carbonate minerals, clay minerals, and augite are auxiliary minerals. The primary intergranular pores, intergranular-dissolved pores, intragranular-dissolved pores, intercrystalline pores, and microfractures are developed in uranium deposits with various lithologies to different degrees. The macropores ( >1000 nm) and mesopores (100-1000 nm) of medium sandstone, argillaceous sandstone, and siltstone are well developed; in contrast, the proportions of micropores ( <10 nm) and transition pores (10-100 nm) in coarse sandstone, fine sandstone, and sandy mudstone are quite high. The heterogeneity of pores in uranium deposits of different lithologies is strong and influences the mineral composition and its fabric mode. Coarse sandstone, fine sandstone, and sandy mudstone are favorable for ISL mining in Qianjiadian uranium deposits because their permeability is above the required permeability threshold of ISL. The uranium deposits with permeability below the threshold are recommended to adopt the blasting-enhanced permeability method to improve their permeability for achieving large-scale and high-efficiency ISL mining. This study can provide guidance for the selection of favorable ore beds for ISL mining and reservoir stimulation methods in low-permeability sandstone-type uranium deposits.
Design and Implementation of Online Japanese Examination System Based on Genetic Algorithm
Authors: Dengqing Zeng , Zhangwei Yang
Published: November 2022

In order to solve the problem of online inspection of students’ theoretical knowledge of Japanese, this paper further optimizes and adjusts the design of the online Japanese examination system and presents an online Japanese examination system based on genetic algorithm. Taking the Japanese test as the research object, on the basis of comprehensively analyzing the problems of slow test paper composition, low success rate, and low quality of traditional online test systems, an intelligent test composition model based on genetic algorithm is proposed, and the implementation process of genetic algorithm and the key steps are described in detail. The results show that the online Japanese examination system based on genetic algorithm can meet the needs of test paper generation in more complex situations. After a long time of operation and continuous improvement, the online Japanese examination system has obtained the adaptability of the best solution. The value of the fitness is 99.666667; when the fitness is at this value, the error of the question type score of the test paper is 0, the average difficulty error on the test paper is 0, and the error of the section test point distribution is 0.666667. This fully illustrates the stability and effectiveness of the Japanese online examination system, which can meet the needs of daily Japanese majors and improve the efficiency of Japanese teaching.
Modelling and Deliberation of Multireinforcement Surface on Tribothermal Adsorption Performance of Nickel Alloy Matrix Hybrid Nanocomposite
Authors: Devi G. Ramya , Priya C. B. , Dineshbabu C. , Karthick R. , Thanigavelmurugan K. , Paramasivam Prabhu
Published: November 2022

The present research work is aimed at developing a nickel alloy (Ni-Cr) matrix hybrid nanocomposite comprising 5 wt%, 10 wt%, and 15 wt% of alumina nanoparticles (Al2O3) size of 50 nm with stable weight percentage (5 wt%) of titanium dioxide (TiO2) nanoparticle via vacuum die casting process for an automobile brake pad application. The deliberation of multireinforcement surface on nickel alloy matrix tribological performance was evaluated by constant sliding distance (200 m) on dry sliding condition via rotating pin on disc apparatus with different loading conditions of 10 N, 30 N, 50 N, and 70 N under the sliding velocity of 0.25 m/sec, 0.5 m/sec, and 0.75 m/sec, respectively. The influences of alumina and titanium dioxide nanoparticles in the nickel alloy matrix resulted in the thermal conductivity increasing by 18% compared to unreinforced nickel alloy. After temperature drop, the coefficient of thermal expansion for nickel alloy hybrid composite decreases progressively with increased reinforcement content as 10 wt% Al2O3/5 wt% TiO2. Further inclusion of both Al2O3 and TiO2 in nickel alloy was increased nominally. The thermal adsorption characteristic on composites mass loss was decreased while temperature increased from 28°C to 1000°C.
Peripheral Tumor Location Predicts a Favorable Prognosis in Patients with Resected Small Cell Lung Cancer
Authors: Gao Yina , Dong Yangyang , Zhou Yingxu , Chen Gongyan , Hong Xuan , Zhang Qingyuan
Published: November 2022

Background. Small cell lung cancer (SCLC) is an aggressive malignancy. Surgical resection is currently only recommended for clinical stage I patients who have been carefully staged. The clinical outcomes of patients with resected SCLCs vary because the disease is highly heterogeneous, suggesting that selected patients could be considered for surgical resection depending on their clinical and/or molecular characteristics. Methods. We collected data on a retrospective cohort of 119 limited-stage SCLC patients who underwent lobectomy with mediastinal lymph node dissection from March 2013 to March 2020 at Harbin Medical University Cancer Hospital. Correlations were derived using Fisher’s exact test. Models of 2-year and 3-year survival were evaluated by deriving the area under receiver operating characteristic curves. Kaplan–Meier and Cox regression analyses were used to evaluate significant differences between the survival curves and hazard ratios. Results. The median disease-free survival (DFS) was 35.9 months (range 0.9–105.3 months), and the median overall survival (OS) was 45.2 months (range 4.8–105.3 months). Univariate analysis showed that TNM stage was significantly correlated with DFS and OS. The 2-year disease-free rates of patients with stage I, II, and III disease were 76.4%, 50.5%, and 36.1%, respectively, and the 3-year OS rates were 75.9%, 57.7%, and 34.4%, respectively. In pN + patients, multiple (or multiple-station) lymph node involvement significantly increased recurrence and reduced survival compared with patients with single or single-station metastases. Patients with peripheral SCLCs evidenced significantly better DFS and OS than did patients with central tumors. Multivariate analysis showed that TNM stage and tumor location were independently prognostic in Chinese patients with resected limited-stage SCLC. A combination of TNM stage and tumor location was helpful for prognosis. Conclusions. TNM stage and tumor location were independently prognostic in Chinese patients with resected SCLCs. Patient stratification by tumor location should inform the therapeutic strategy. The role of surgical resection for limited-stage SCLC patients must be reevaluated, as this may be appropriate for some patients.
Container Ship Carbon and Fuel Estimation in Voyages Utilizing Meteorological Data with Data Fusion and Machine Learning Techniques
Authors: Ren Feiyang , Wang Shaohan , Liu Yuanzhe , Han Yi
Published: November 2022

The International Maritime Organization (IMO) had made effort to reduce the ship’s energy consumption and carbon emission by optimizing the ship’s operational measures such as speed and weather routing. However, existing fuel consumption models were relatively simple without considering the quantified effect of weather conditions. In this paper, a knowledge-based ridge regression-based algorithm is presented for enabling automated fuel consumption estimation under varying weather conditions during voyages. Wind speed, wave height, ship speed, draught, AIS segment distance, and ship’s heading (HDG) are used as input to predict the fuel consumption value from the MRV report. In this work, 3 types of models are tested: AIS-based model, MRV-based model, and MRV-based normalized model. In AIS based model, weather conditions are divided into nine categories based on wind speed, wave height, and wind directions then trained separately. In MRV-based mode, the daily weather condition was used, and the MRV-normalized model used the normalized daily weather data. The proposed ridge regression models (11 models total) were tested with 4 container ships for a period of one year, and the result shows that compared to real fuel consumption, MRV-based model could achieve the best result with an average error less than 3% comparing to real MRV report.
The Number of Positive Tumor Markers (NPTM) Achieves Higher Value in the Prognosis Prediction of Gastric Cancer
Authors: Li Limin , Ma Bing , Liu Fubin , Sheng Chao , Peng Yu , Qiao Yating , Wang Peng , Chen Kexin , Song Fangfang
Published: November 2022

Purpose. The clinical application of combined tumor markers is still limited. We aim to explore the value of the combination of multiple tumor markers in gastric cancer (GC) prognosis. Methods. The prognostic significance was evaluated using Kaplan–Meier log-rank survival analysis and multivariable Cox regression analysis. The estimated area under the curve (AUC) was compared to evaluate the discriminatory ability of different indicators. A nomogram was constructed based on the results of multivariable cox regression, and its performance was evaluated by Harrell’s concordance index and calibration curve. Results. NPTM (number of positive tumor markers) displayed independent prognostic significance whether in the whole cohort or in patients with different stages. Patients with the all-negative tumor markers had a worse prognosis after postoperative chemotherapy in all cohort (

P
=
0.023

) or in age ≤60 subgroup (

P
=
0.012

), while patients with positive tumor markers had a better prognosis after postoperative chemotherapy in stage III (

P
=
0.012

). The AUC value of NPTM is higher than any individual tumor marker. The 1-, 3-, and 5-year AUC values of the CTNM (combination of NPTM and pTNM) increased by 5%, 4.8%, and 3.6%, respectively, compared with TNM staging system. The nomogram constructed including NPTM showed its high accuracy (

C
−
index
=
0.706

) versus TNM staging system (

C
−
index
=
0.646

) and CTNM (

C
−
index
=
0.681

). Conclusions. NPTM was an independent predictor of gastric cancer prognosis, showing more accurate prognostic performance than individual tumor markers. Especially its significance in guiding postoperative adjuvant chemotherapy regimens and predicting prognosis by combination with TNM staging system may have a better clinical application value.
Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure
Authors: Li Ming , Xiao Yu-Bo , Wei Le , Liu Qi , Liu Pin-Yue , Yao Jian-Feng
Published: November 2022

Premature ovarian failure (POF) is characterized by hormonal disorders, amenorrhea, and premature loss of fertility potential in women of reproductive age. Several studies have been conducted on the effectiveness of traditional Chinese medicine (TCM) in treating POF. TCM relied primarily on apoptosis, immunity, and aging to treat POF based on the studies of domestic and foreign literature. Zuogui pills inhibited mitochondrial-dependent apoptosis in the treatment of POF. Huyang Yangkun formula regulated the downstream of the Bcl-2 family to resist apoptosis through the aquaporin-1 protein. Modified Bazhen decoction regulated apoptosis in POF by regulating X-linked inhibitors of apoptosis protein. Bushen Tianjing recipe was effective in treating POF by promoting angiogenesis and preventing apoptosis. As for immunity, Bushen Jianpi prescription and Er-Xian decoction cured autoimmunity POF models and increased follicular development-related protein expression. Bushen Huoxue Tang improved ovarian function and reduced ovarian inflammation by regulating the Nrf2/Keap1 signaling pathway and T lymphocytes. Taohong Siwu decoction promoted the proliferation and differentiation of granulosa cells of POF mice by regulating the TGF-β1/Smads signaling pathway. In addition, ginsenoside Rg1 and Jiajian Guisheng formula treated POF by regulating cell aging-related mechanisms. Si Wu Tang treated POF by activating the angiogenesis-related proteins. The goal of this review is to serve as a reference for in-depth research into the treatment of POF with TCM and provide inspiration for new diagnostic methods and treatment options.
IoV-SDCM: An IoV Secure Data Communication Model Based on Network Encoding and Relay Collaboration
Authors: Sun Yan , Yin Lihua , Ma Ying , Wang Chonghua
Published: November 2022

Internet of Vehicles (IoV) is a significant 5G application scenario. As it developed rapidly, more and more vehicles are connected to Internet of Vehicles. The data security and privacy are the premises to ensure its service quality in an open communication network. This paper proposes IoV-SDCM, a secure data communication model in IoV. It includes a self-organizing relay forwarding network and an assured delivery mechanism. The relay forwarding network is used for constructing a dynamic collaboration network with the vehicle as the node. The security delivery mechanism is that network coding is used for data fragmentation and re-encoding to improve network communication reliability. Homomorphic encryption is used to encrypt and protect the encoding vector, improving information leakage and anticollusion attacks. The theoretical proof proves that the model has the ability of data transmission confidentiality and better antiattack capabilities, while it has privacy protection capabilities. Furthermore, the experiment verifies that the model also has the advantage of high and stable data delivery efficiency.
Catalpol Regulates Oligodendrocyte Regeneration and Remyelination by Activating the GEF-Cdc42/Rac1 Signaling Pathway in EAE Mice
Authors: Wu Minghui , Kang Qi , Kang Yuezhi , Tong Yanping , Yang Tao , Fan Yongping
Published: November 2022

The main obstacle to remyelination in demyelinating diseases, such as multiple sclerosis, is the inability of oligodendrocyte precursor cells (OPCs) to differentiate into mature oligodendrocytes (OLs) in the demyelinating region. Consequently, promoting OL differentiation and myelin remodeling is a key goal in the search for treatments. Rho GTPases play diverse and important roles throughout the development of neuronal axons and the formation of the myelin sheath. The current study aimed to investigate the direct protective effects of catalpol on demyelination damage induced by myelin oligodendrocyte glycoprotein (MOG) immunization and to explore whether the GEF-Cdc42/Rac1 signaling pathway contributes to the regeneration effect induced by catalpol. In the MOG-induced experimental autoimmune encephalomyelitis (EAE) mouse model of demyelination, we observed that catalpol significantly promoted OL development by enhancing the expression of glutathione S-transferase pi (GST-pi) in the affected brain. By Luxol fast blue staining and myelin basic protein (MBP) expression assessment, catalpol was found to increase MBP expression and promote myelin repair. Furthermore, catalpol promoted OL differentiation associated with the upregulation of Cdc42/Rac1 expression and activation in vivo. In addition, PAK1/MRCKα, proteins downstream of Cdc42/Rac1, was positively regulated by catalpol. We also found that catalpol alleviated clinical neurological dysfunction, inhibited inflammatory infiltration, increased the proportion of Treg cells, and suppressed demyelination. Overall, our study is the first to reveal that catalpol can promote OL generation and myelination and contributes to the crucial regulatory process of GEF-Cdc42/Rac1 signaling expression and activation. Therefore, catalpol is a promising drug candidate for the potential treatment of demyelinating diseases.
Potential of Phosphorus Solubilizing Purple Nonsulfur Bacteria Isolated from Acid Sulfate Soil in Improving Soil Property, Nutrient Uptake, and Yield of Pineapple (Ananas comosus L. Merrill) under Acidic Stress
Authors: Huu Tran Ngoc , Giau Tran Thi Ngoc , Ngan Phan Ngoc , Van Tran Thi Bich , Khuong Nguyen Quoc
Published: November 2022

This study aimed to (i) evaluate purple nonsulfur bacteria (PNSB) strains possessing the highest phosphorus (P) solubilizing capacity in field and (ii) determine the efficacy of PNSB biofertilizers in improving soil quality, P uptake, growth, and yield of pineapple cultivated in acid sulfate soil (ASS). A field experiment was conducted in a completely randomized block design with two factors, including the first factor as P fertilizer levels (0, 50, 75, and 100% P) based on recommended fertilizer formula (RFF) and the second factor as supplementation of biofertilizers containing P solubilizing PNSB (no inoculated PNSB, Rhodobacter sphaeroides W48, R. sphaeroides W42, and a mixture of R. sphaeroides W48 and W42). The results indicated that the supplementation of PNSB biofertilizers led to an increase of 25.3–33.9% in soluble P concentration in soil compared to control treatment. Among the selected PNSB strains, R. sphaeroides W42 and a mixture of the PNSB in biofertilizers solubilized all insoluble P fractions (Fe-P, Al-P, and Ca-P) and strain W48 in biofertilizers for Fe-P and Al-P. Furthermore, the supplementation of biofertilizers from R. sphaeroides W48 and W42 individually and their mixture raised plant height by 3.56–4.10% and available P concentration by 25.3–33.9%. Total P uptake in pineapple treatments with biofertilizers from mixed PNSB was 42.9% higher than that in the control treatment (

p
<
0.05

). Application of mixed PNSB strains can reduce 25% P of chemical fertilizer, but the pineapple yield rose over 12.1%. Both R. sphaeroides W48 and W42 are potent for use as crop yield enhancers to obtain the sustainable pineapple cultivation under acidic stress.
Complete Surgical Resection of a Giant Invasive Thymoma with Right Pneumonectomy and Graft Reconstruction of the Superior Vena Cava and Left Brachiocephalic Vein: A Case Report
Authors: Lampridis Savvas , Bilkhu Rajdeep , Lucchese Gianluca , Billè Andrea
Published: November 2022

Background. Complete surgical resection represents one of the most important prognostic factors for thymomas. However, surgery is usually not considered when there is invasion of the pulmonary hilum and mediastinal veins because of technical considerations or potential perioperative morbidity and mortality. Case Presentation. We present the case of a 37-year-old woman with a giant thymoma infiltrating the superior vena cava, left brachiocephalic vein, and most of the right lung. Following 3 cycles of chemotherapy with minimal tumour response, she was hospitalised with COVID-19 and refused further systemic treatment. She subsequently underwent surgery after a thorough preoperative evaluation. Surgical resection of the tumour was performed with concomitant right pneumonectomy and reconstruction of the superior vena cava and left brachiocephalic vein using expanded-polytetrafluoroethylene grafts through a median sternotomy combined with a clamshell incision. Histopathological analysis of the resected specimens demonstrated a type B2, Masaoka-Koga stage IVa thymoma that was completely resected. Following an uneventful course, she was discharged home on the ninth postoperative day with anticoagulation therapy. She has remained free of disease or adverse events after a 12-month follow-up. Conclusions. Complete surgical resection of invasive thymomas with concomitant pneumonectomy and venous graft reconstruction is a feasible and safe procedure. Careful patient selection and adequate postoperative anticoagulation are crucial for successful clinical outcomes.
A new species of genus Neocerura Matsumura, 1929 (Notodontidae: Lepidoptera) from India
Authors: Amritpal Singh Kaleka  , Rishi Kumar
Published: November 2022

A new species Neocerura convergata under the genus Neocerura Matsumura, 1929 has been described and illustrated.  This species is closely related to N. liturata Walker, 1855 (type species) and completely conforms to the characterization of the genus.  The wing maculation, larger size, and genitalic features make it distinct.  The taxonomic account of N. liturata Walker, 1855 has also been included.  The revival of the genus Neocerura Matsumura, 1929 has also been justified.
New records of pteridophytes in Mount Matutum Protected Landscape, South Central Mindanao, Philippines with notes on its economic value and conservation status
Authors: Christine Dawn Galope-Obemio  , Inocencio E. Buot Jr.  , Maria Celeste Banaticla-Hilario
Published: November 2022

New records on distribution of pteridophytes in Mount Matutum Protected Landscape were documented. The species list was accounted with reference to specimen collections from various herbaria posted in digital databases and reliable literature on pteridophyte flora. Results further showed 105 new records for MMPL and its vicinity-South Cotabato, Sarangani province and General Santos City.  From these, seven were new records for South Central Mindanao Region (Region 12). About 19 families, 56 genera were represented – 41 were epiphytes, 10 lithophytes, and 45 soil inhabitants, the rest with dual habits – two (ground and lithophytic); seven (epiphytic and lithophytic). Moreover, 11 species were found to be threatened based on national list while local conservation assessment based on relative frequency noted 91 threatened species. A conservation plan for these valuable species in the protected landscape is also proposed to ensure sound intervention and sustainable environment for this plant group.
Population abundance and threats to Black-headed Ibis Threskiornis melanocephalus and Red-naped Ibis Pseudibis papillosa at study sites in Jhajjar district, Haryana, India
Authors: Anjali  , Sarita Rana
Published: November 2022

The Black-headed Ibis and Red-naped Ibis are large wading birds of the order Pelecaniformes. This study documents abundance and threats affecting both species at Dighal, Gochhi, and Chhochhi villages located in Jhajjar district, Haryana, India. Field visits were made twice a month at each site from October 2020 to September 2021. Dighal had proportionately the largest populations of both species. Black-headed Ibis were most abundant in wetlands and Red-naped Ibis in agricultural areas. Populations of both species did not vary among seasons. Major threats observed included dumping of solid waste, fishing, growth of weeds, release of untreated sewage, collisions with transmission lines, grazers (e.g., cattle and goats), and stray dogs. The findings of this study suggest that despite having sizable populations near Dighal, both species face major threats and conservation efforts will require monitoring and management of ibis habitat.
Status of mangrove forest in Timaco Mangrove Swamp, Cotabato City, Philippines
Authors: Cherie Cano-Mangaoang  , Zandra Caderon Amino  , Baingan Brahim Mastur
Published: November 2022

Mangrove forests are important coastal ecosystem considering its various ecosystem services.  This study was conducted to generate an updated list and the current abundance of mangrove species in Timaco Mangrove Swamp located in Cotabato City, Bangsamoro Autonomous Region for Muslim Mindanao (BARMM).  Three sampling plots measuring 5 x 40 m were established in three identified sampling sites.  Based on the result of the study, 15 species of mangroves were identified in Timaco Mangrove swamp.  This number of species is higher compared to the previous study wherein 12 species were identified.  With this number of species, seven species were considered new in the area, and five species were not recorded which were identified in the previous study.  A total of 115 individuals were recorded in the present study which indicates a decrease of 79% compared to the previous study.  Furthermore, the present study recorded two threatened species, namely, Aegiceras floridum (Near Threatened) and Avicennia rumphiana (Vulnerable).  Continuous anthropogenic activities were observed in the sampling sites which can be attributed to population decrease.  Thus, the need for immediate local conservation is recommended.
A comparative analysis of the past and present occurrences of some species of Paphiopedilum (Orchidaceae) in northeastern India using MaxEnt and GeoCAT
Authors: Dutta Debonina , De Aparajita
Published: November 2022

Members of the genus Paphiopedilum are well known for their long-lasting unique flowers. They are becoming rare due to over-collection and habitat loss because of human disturbances and deforestation. The present study aimed to compare the past and present occurrences of the genus Paphiopedilum in northeastern India using MaxEnt and GeoCAT. A historical occurrence model (HOM) was prepared using secondary data, and an actual occurrence model (AOM) was constructed with primary field data. The HOM and AOM revealed that bioclimatic factors, topography and precipitation play a significant role in the survival of Paphiopedilum populations in northeastern India in both the current and historical distributions. The other vital environmental variables were elevation (h_dem), mean diurnal range (bio_2), annual mean temperature (bio_1), temperature annual range (bio_5) and annual precipitation (bio_12). The results showed a sharp decline in the extent of occurrence and the area of occupancy of Paphiopedilum in the study area. The extent of occurrence and area of occupancy for HOM were 170,972 km2 and 18 km2. For the AOM, they were 125,315 km2 and 12 km2, respectively. The HOM model indicated that Paphiopedilum was earlier growing sporadically. On the other hand, the AOM result indicates that it is presently growing sparsely in isolated pockets that are more prone to extinction. Paphiopedilum can be conserved successfully using an integrative conservation approach, comprising ecological modeling techniques to search for additional locations, ex situ propagation techniques, and possible reintroduction in selected areas.
Rediscovery of an interesting preying mantis Deiphobella laticeps (Mantodea: ­Rivetinidae) from Maharashtra, India
Authors: Sathaye Gauri , Sachin Ranade  , Ghate Hemant V.
Published: November 2022

Deiphobella laticeps (Wood Mason, 1876), is an interesting preying mantis, rediscovered from Maharashtra State, India, after considerable lapse of time since its original description.