bluuebunny/crossref_metadata_2025 huggingface dataset:
Five-axis material extrusion of high-performance structural parts with continuous carbon fiber-reinforced LM-PAEK
Authors: Heathman Nathaniel , DeLay Michael , Tehrani Mehran
Published: November 2024

Additive manufacturing (AM) offers numerous advantages over standard manufacturing methods, such as design freedom and enabling limited production run components. Using continuous fiber-reinforced polymer composites, polymer AM can now produce end-use components with mechanical properties rivaling metals. In this paper, five-axis continuous fiber material extrusion (ME) is utilized to manufacture specimens from high-performance semi-crystalline low-melt polyaryletherketone™ (LM-PAEK™) composite. ASTM standardized testing showed record matrix-dominated and flexural properties for as-printed parts, with low porosity and high crystallinity. Annealing did not change mechanical properties or crystallinity. Additionally, steering radii specimens and a complex geometric bracket were manufactured using the full out-of-plane 3D printing capability of the five-axis equipment; subsequent X-ray computed tomography showed multiple manufacturing defects and voids when printing high-curvature rasters. Results thus pave the way for using LM-PAEK™ to replace other high-performance polymers in continuous fiber AM, although designers should take note of fiber steering in critical load-bearing structures.
S-adenosylmethionine inhibits non-small cell lung cancer and enhances chemosensitivity by targeting the P62/NF-κB axis and regulating autophagy and oxidative stress
Authors: Jin Xuehang , Zhang Lvjun , Ying Chiqing , Yu Long , Guo Xuejing , Pan Kailing , Zhu Dan , Chen Hui , Lou Yan , Qiu Yunqing
Published: November 2024

Background
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. S-adenosylmethionine (SAM), a key metabolite in the methionine cycle, has indicated potential for cancer therapy and enhancing chemotherapy sensitivity. However, its effects on NSCLC remain undetermined.
Methods
Cell lines and mouse models were utilized to assess the anti-tumor efficacy of SAM. We constructed biotin-labeled SAM and truncated P62 expression plasmids for further immunocoprecipitation-mass spectrometry experiments.
Results
SAM inhibits NSCLC growth and enhances chemosensitivity both in vitro and in vivo. Mechanistic investigations revealed that SAM plays a significant regulatory role in autophagy and oxidative stress within NSCLC. Furthermore, we identified P62 as a critical target of SAM. Both in vitro and in vivo studies confirmed that P62 mediates SAM regulatory effects on NSCLC. Further study discovered that SAM inhibits the NF-κB signaling pathway by directly targeting the ZZ and TB domains of the P62 protein, thereby blocking autophagy and activating oxidative stress.
Conclusions
These findings highlight SAM as a novel inhibitor of the P62/NF-κB axis and suggest that SAM could be a potential therapeutic agent for NSCLC.
Design, synthetic approches, structure-activity relationship strategy and antibacterial evaluation for N-alkylated derivatives with binding mode of chloroquinoline- thiazolidinedione based hybrids
Authors: Juddhawala Krunal V. , Parekh Nikhil M.
Published: November 2024

A variety of new compounds have been integrated into the structural framework of (5Z)-5-[(2-(4-methylpiperazin-1yl)quinoline-3-yl)methyl]-1,3-thiazolidine-2,4-dione. The synthesis of 1,3-thiazolidine-2,4-dione was accomplished by means of the condensation of 2-chloroquinoline, which later functioned as a pivotal reagent in the reaction with 3-carbaldehydes, resulting in the production of 2,4-thiazolidinedione. The characterization of these recently synthesised compounds was performed by their interactions with halide compounds, namely involving substituted N-alkylation. Chemical identification was achieved by using elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), and proton nuclear magnetic resonance spectroscopy (1H-NMR). Additionally, the synthesised compounds were subjected to in vitro testing to assess their antibacterial activity against a range of pathogens, such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa.
Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons
Authors: She Xiwei , Moore Bryan J. , Roeder Brent M. , Nune George , Robinson Brian S. , Lee Brian , Shaw Susan , Gong Hui , Heck Christianne N. , Popli Gautam , Couture Daniel E. , Laxton Adrian W. , Marmarelis Vasilis Z. , Deadyler Sam A. , Liu Charles , Berger Theodore W. , Hampson Robert E. , Song Dong
Published: November 2024

The hippocampus is crucial for forming new episodic memories. While the encoding of spatial and temporal information (where and when) in the hippocampus is well understood, the encoding of objects (what) remains less clear due to the high dimensions of object space. Rather than encoding each individual object separately, the hippocampus may instead encode categories of objects to reduce this dimensionality. In this study, we developed and applied a combined experimental-modeling approach to investigate how the hippocampus encodes visual memory categories in humans. We recorded spikes from hippocampal CA3 and CA1 neurons in 24 epilepsy patients performing a visual delayed match-to-sample (DMS) task involving five image categories. An ensemble multi-temporal-resolution classification model was employed to decode these visual memory categories from the hippocampal spiking activity with moderate numbers of trials. This model enables the identification of the spatio-temporal characteristics of hippocampal encoding through its interpretable representations. Using this model, we estimated the optimal temporal resolutions for decoding each visual memory category for each neuron in the ensemble. Results indicate that visual memory categories can be decoded from hippocampal spike patterns despite the short data length, supporting the presence of category-specific coding in the human hippocampus. We found that hippocampal neuron ensembles encode visual memory categories in a distributed manner, akin to a population code, while individual neurons use a temporal code. Additionally, CA3 and CA1 neurons exhibit similar and redundant information regarding visual memory categories, likely due to the strong and diffuse feedforward synaptic connections from the CA3 region to the CA1 region.
The rise of the worm: bibliometric insights into the growing significance of vermicomposting for sustainable agriculture and environmental management
Authors: Mhamdi Ridha
Published: November 2024

Purpose This paper presents a comprehensive bibliometric analysis of vermicomposting research over the past decade, focusing on its several advantages to sustainable agriculture and waste management.
Method The study encompasses 3259 papers published during the last decade (2013-2022), with a focus on the last five years to identify emerging trends.
Results A substantial growth in vermicomposting research is observed, with an annual publication output doubling from 2013 to 2022. Subject area analysis reveals prominence in Agricultural and Biological Sciences and Environmental Science. International collaboration has increased over the decade, with India leading in quantity but displaying a Field-Weighted Citation Impact (FWCI) below the global average. Other countries, including China, Spain, USA, and Malaysia, exhibit higher FWCI scores. Academic-corporate collaboration is limited, with only 9 papers resulting from such partnerships. Patent analysis indicates a growing interest in vermicomposting-related innovations, with 35 patents published since 2015, emphasizing sustainable practices in agriculture and waste management.
Conclusion Emerging trends encompass the development of methods for assessing vermicompost maturity and investigating its integration with other waste treatment technologies, optimization of vermicomposting through feedstock diversification, process fine-tuning, and innovative reactor designs, and environmental applications, involving the removal of heavy metals, degradation of microplastics, and wastewater treatment.
The Impact of Corporate Social Responsibility on Financial Performance, Financial Inclusion, and Financial Stability: case of Tunisia
Authors: Fatma Felhi
Published: November 2024

The aim of this study is to analyze how Corporate Social Responsibility (CSR) affects the financial performance, financial inclusion, and financial stability of financial institutions in Tunisia. The research focuses on data from 30 financial institutions collected annually from 2008 to 2019. The results show that CSR, along with the age and size of the institution, positively influences all three factors. On the other hand, higher levels of debt have a negative impact on financial inclusion and financial stability. Moreover, financial inclusion is negatively correlated with asset tangibility.
ЛАТЕНТНОЕ ВАРВАРСТВОПРИРОДА ЯВЛЕНИЯ, ИСТОРИЧЕСКАЯ ЭВОЛЮЦИЯ(РОССИЙСКИЙ ОПЫТ)
Authors: И.Г. ЯКОВЕНКО
Published: November 2024

В статье, на российском материале, рассматривается природа латентного варварства. Исследуется возникновение этого феномена, его историкокультурная эволюция. Описываются значимые характеристики сознания и поведения латентного варвара. Автор предлагает культурологическую интерпретацию исследуемого явления. Особое место занимает проблема ментальности. Варвар, как и любой иной человеческий тип, задается соответствующей ментальностью. Отсюда внимание к проблеме межпоколенческого воспроизводства варварского сознания, которое задается процессами инсталляции ментальности.

In the article, on the Russian material, the nature of latent barbarism is considered. The origin of this phenomenon, its historical and cultural evolution is investigated. The significant characteristics of consciousness and behavior of the latent barbarian are described. The author offers a culturological interpretation of the phenomenon under study. A special place is occupied by the problem of mentality. The barbarian, like any other human type, is given the appropriate mentality. Hence the attention to the problem of intergenerational reproduction of barbaric consciousness, which is set by the processes of installation of mentality.
«ВАРВАРСТВО ЦИВИЛИЗАЦИИ»ЛИЦОМ К ЛИЦУС «ЦИВИЛИЗАЦИЕЙ ВАРВАРСТВА»: ФЕНОМЕН ЛАТЕНТНОГО ВАРВАРСТВА В КОНТЕКСТЕ ГРЕКО-РИМСКОЙ ЦИВИЛИЗАЦИИ I В. ДО Н.Э.(ПО ПРОИЗВЕДЕНИЯМ ЦИЦЕРОНА)
Authors: В.О. НИКИШИН
Published: November 2024

Статья посвящена примерам латентного варварства в произведениях Цицерона. В первую очередь автор анализирует терминологию Цицерона и в результате приходит к выводу, что оратор делил все человечество на три категории, а именно греков, римлян и варваров. Кроме того, Цицерон отметил еще одну промежуточную категорию так называемых полуварваров (примеры: галлогреки и боспораны). В произведениях Цицерона мы находим примеры того, как греки (Graeculi), римляне (Пизон, Антоний, Долабелла) или эллинизированные полуварвары (Брогитар I, Кастор II) проявляют варварские свойства натуры, т.е. черты, чуждые культурному образу жизни (vita perpolita humanitate). Наконец, автор приходит к выводу, что практически во всех случаях те характеристики и оценки, которые Цицерон давал тем или иным лицам, в значительной степени зависели от его личного отношения к этим людям.

This article is devoted to the examples of latent barbarity in the works of Cicero. First of all the author analyzes the terminology of Cicero and as a result comes to a conclusion that the orator divided the whole mankind in three categories which were the Greeks, the Romans and the Barbarians. Besides that Cicero marked one else intermediate category of the socalled halfbarbarians, for example the Gallogrecs and the Bosporans. In the works of Cicero we find some examples of that the Greeks (Graeculi), the Romans (Calpurnius Piso, Antony and Dolabella) or hellenized halfbarbarians (Brogitarus I, Castor II) showed barbaric features of their proper characters, i.e. traits which were alien to the cultural way of life (vita perpolita humanitate). Finally, the author comes to a conclusion that practically in all the cases those characteristics and estimates, which Cicero gave one or another person, to a great extent depended on his own attitude to these people.
МЕЖДУ «ЦИВИЛИЗАЦИЕЙ» И«ВАРВАРСТВОМ»: В ПОИСКАХ РИМСКО-ИТАЛИЙСКОЙ ИДЕНТИЧНОСТИ
Authors: В.А. КВАШНИН
Published: November 2024

Статья посвящена проблеме культурного влияния греческих полисов Южной Италии на Рим. Одним из проявлений этого было проникновение комплекса идей и мифологем греческого происхождения, призванных обосновать родство различных народов Италии с эллинским миром. Италийские общины восприняли и адаптировали идеологические модели, созданные в Афинах в VIV вв. до н.э. Следствием этого было возникновение определенных идеологических ориентиров, объяснявших успехи племен Центральной Италии их приверженностью к более простому и умеренному образу жизни. Возникновение тенденции к конструированию греческого происхождения народов Италии было связано со стремлением самых разных полисов и этнических групп к подобной самоидентификации в свете славы имперского успеха, сформировавшейся после Восточного похода Александра Македонского на базе афинских идеологических разработок.

The article is devoted to the problem of cultural influence of the Greek policies of Southern Italy on Rome. One of the manifestations of this process is the assimilation of a complex of ideas and myths of Greek origin, designed to form the relationship of different peoples of Italy with the Hellenistic world. The Italian community embraced and adapted the ideological models created in Athens in the VIV centuries B.C. The result was the creation of some ideological concepts explaining the success of the tribes of Central Italy by their commitment to a simple and moderate lifestyle. The emergence of the trend towards the construction of the Greek origin of the peoples of Italy was associated with the desire of a variety of policies and ethnic groups to such the selfidentification in the light of the glory of the imperial success, formed after the Eastern campaign of Alexander the Great on the basis of Athenian ideological concepts.
ЭЛЕМЕНТЫ ЛАТЕНТНОГОВАРВАРСТВА В ЭЛЛИНСКОЙКУЛЬТОВОЙ ПРАКТИКЕ
Authors: Л.Г. ШЕПКО
Published: November 2024

Статья посвящена элементам культовой практики греков, которые наиболее ярко проявляются в массовых общественных действах праздниках и присутствуют в погребальнопоминальных сценариях. Праздники и погребальные церемонии представителей варварского мира (скифов, тюрок) включают такие же элементы. Анализируя эллинский и варварский миры в синхронном контексте, общность обрядов и культовой практики их представителей обычно рассматривают в рамках взаимодействия и заимствования. Сценарии социально значимых мероприятий опираются на мировоззренческую основу общиннородового строя. Выработанный алгоритм коллективных действий сохраняется достаточно долго. Цивилизация привносит разнообразие формы, но в полной мере не может скрыть стадиально варварский компонент на цивилизационном этапе эволюции эллинов.

The article depicts the elements of the Greek cult practices. Processions, initiations, sacrifices, cleansing, competitions, etc. are most vividly manifested in mass public events holidays. They are also present in the ancient Greek funeral / memorial scenarios. Holidays and funeral ceremonies of the barbarian world representatives (Scythians, Turks) include the same elements which may, however, differ in their sequence. Analyzing the Hellenic and Barbaric worlds in a synchronous context, scholars usually think the commonality of rituals and the cult practices of their representatives to be in the framework of interaction and borrowing. At the same time, the formation of scenarios for socially significant events is based on the ideological basis of the communalclan system. Thus, the algorithm of collective actions develops, maintaining itself for a long time. Civilization introduces variety of forms but cannot fully conceal the barbaric stage component at the new civilization level of the Hellenic evolution.
ЛАТЕНТНОЕ ВАРВАРСТВОМЕЖДУ ВАРВАРСТВОМ ИЦИВИЛИЗАЦИЕЙ
Authors: М.Г. ГУСАКОВ
Published: November 2024

Статья посвящена латентному варварству в поздней Римской империи. Латпнтное варварство, т.е. скрываемое или скрытое варварство, понимается как варварство в олеждах цивилизации. Солдат римской армии, варвар по происхождению, сохраняя полностью или частично менталитет варвара, осваивал латынь, элементы римской культуры, прннимал нормы жизнедеятельности цивилизованного общества. Его притягивали возможности и желание воспользоваться плодами чужой цивилизации. Помимо армии для варваров дорогой в цивилизацию было рабство. Объективно раб имел возможность стать вольным человеком и даже войти в число обеспеченных, а в ряде случаев и богатых людей, скрыто, не всегда разделяя при этом ценности и нормы цивилизации. По мере увеличения числа подобных латентных варваров возрастали конфликты между ними и гражданами Рима. В итоге бывшие варвары, войдя в Рим, постепенно разрушали его, что привело к глубокому кризису всей системы.

The article is devoted to the problem of the latent barbarism in the Late Roman empire. Latent barbarism, i.e. hidden or disguised barbarism, is understood as barbarism wearing civilized clothes. The soldiers of the Roman army, barbarian by origin, keeping all or part of the mentality of the barbarian, mastered the Latin and the elements of Roman culture, accepted primal norms of life of a civilized society. He was attracted by the opportunities and the desire to take advantage of the fruits of alien civilization. In addition to the army for the barbarians the way to civilization was slavery. Objectively, the slave had the opportunity to become a free man and even enter the number of wealthy, and in some cases rich people, not always secretly sharing the values and norms of civilization. As the number of such latent barbarians increased, conflicts between them and the citizens of Rome increased. In the end, the former barbarians, entering Rome, gradually destroyed it, which led to a deep crisis of the whole system.
Политические и географические границы Южного Кавказа (Закавказья)
Authors: А.К. Шагинян
Published: November 2024

В настоящем исследовании на основании сведений из литературных памятников античной и раннесредневековой географии, а также многочисленных статей из ведущих справочных изданий мира XIXXX вв. представлены и проанализированы термины, касающиеся исторической географии Южного Кавказа (Закавказья) и смежных областей Армянского нагорья. Автор критикует устоявшееся в отечественной литературе, официальной документации и СМИ мнение о южных границах Южного Кавказа (Закавказья). Он показывает, что политические границы Южного Кавказа (Закавказья) на юге значительно шире географических границ, охватывая северо-восточные регионы обширной физико-географической области Армянское нагорье, которые в первой трети XIX в. были включены в состав Российской империи, а после оказались в составе Советского Союза.

In the paper, based on information from the literary sources of ancient and early medieval geography, as well as numerous articles from leading reference books of the world of the 19th20th centuries, the terms applied to the historical geography of the South Caucasus (Transcaucasia) and adjacent areas of the Armenian Highlands are presented and analyzed. The opinion on the southern borders of the South Caucasus (Transcaucasia), which has been established in Russian literature, official documentation and the media is criticized. The author shows that the political borders of the South Caucasus (Transcaucasia) in the south are much wider than geographical borders, covering the northeastern regions of the vast physical and geographical area of the Armenian Highlands, which were included in the Russian Empire in the first third of the 19th century, and later became part of the Soviet Union.
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Authors: Seewan Mohammed Taher Bebane
Published: November 2024

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ئیستاتیکای فرەجۆریی دەقئاوێزان لە شیعرەکانی صافی هیرانی دا
Authors: Naz Ahmad Saeed  , Avin Asos Hama
Published: November 2024

پوخته
  گەشەو ئیستاتیکای ئەدەبی، لە هەندێ بارودۆخدا پەیوەستە بە پەیوەندییە ناوخۆییەكان. دەقئاوێزان، وەك میتۆد و ڕێبازێكی ڕەخنەیی، یارمەتیدەرێكی وزەبەخشی ئەرێنیە بۆ دەرخستنی فۆرمی ئەم گەشە و ئیستاتیکایە، جگە لەوەی یەکێک لە تایبەتمەندییەکانی دەقی ئەدەبی ئەوەیە کەوا هەر دەقێک دەشێت لە پەیوەندییەکی کارتێکردندا بێت لەگەڵ دەقەکانی پێش خۆی، ئەمەش وەک دیاردەیەکی ئەدەبی بەرچاودەکەوێت، کەوا لەژێر ڕۆشنایی دەقئاوێزاندا خۆی بەرجەستە دەکات. بەم پێیە ئەم توێژینەوەیە هەوڵێکە بۆ دەرخستنی ئەو سیما ئیستاتیکیانەی لە ئەنجامی فرەجۆریی دەقئاوێزان لە شیعرەکانی صافیدا بەرچاودەکەون.
    دەقئاوێزان وەک دیاردەیەکی ئەدەبی، پەیوەستە بە ڕادەی کاریگەری و کارتێکردنی شاعیران لەگەڵ یەکتری، لەبەرئەوە صافی هیرانی وەک شاعیرێکی کلاسیک لە ژێر کاریگەری شاعیرانی کلاسیکدابووە و لە هەمانکاتیشدا هۆشیاری و باڵادەستی شاعیر بەسەر دیاردە ئەدەبی و کلتورییەکان و ڕۆشنبیرییەکانی قۆناغەکەی، ئەنجامی ئەو کاریگەرییە پیشاندەدات. لەبەر ڕۆشنایی ئەم کاریگەرییەدا توێژینەوەکەمان ئەو ڕەهەندە ئیستاتیکییانەی دەرخستووە کەوا فرەجۆریی دەقئاوێزان لە دەقە شیعرییەکانی شاعیردا دەردەخەن، هەروەک؛ دەرخستنی ئەو دیاردە دەقئاوێزانیانەی لە ئەنجامی کاریگەری شاعیرانی کلاسیک لەلایەک و لەلایەکی تریش ئەو ڕەهەندانەی دەقئاوێزانی کلتوری وئاینی ڕۆشنبیری و فۆلکلۆری دەردەخەن.
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Authors: Shaida Basim Abdullah  , Darya Jamal Hawez
Published: November 2024

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CHEMOTYPE VERBOCCIDENTAFURAN IN Baccharis punctulata (Asteraceae): FURANIC SESQUITERPENES CORRELATION AND MOLECULAR DOCKING INTO THE BENZODIAZEPINE RECEPTOR
Authors: Ascari Jociani , de Oliveira Murilo S. , Rüdiger André L. , Elisabetsky Elaine , Nunes Domingos S. , Iulek Jorge , Scharf Dilamara R. , Heiden Gustavo
Published: November 2024

The compound verboccidentafuran (1) was identified from the essential oil of the leaves of Baccharis punctulata DC. (Asteraceae) specimens for the first time in Brazil. The variation of this compound found in male and female specimens may be associated to the existence of more than one type of chemotype, influenced by geographic variation, climatic conditions, stage of the vegetative cycle,
genetic and ecological factors. The furanocadinan-type sesquiterpenes verboccidentafuran (1) and curzerene (2) have molecular descriptors with high similarities. Compound 2, found in Eugenia uniflora L. (Myrtaceae) and species of the genus Smyrnium L. (Apiaceae), is active to control seizures induced by pentylenetetrazole, what suggests a possible binding to the benzodiazepine-site of the GABAA (gamma-aminobutyric acid type A) receptor. Considering the occurrence and availability of 1 in the species B. punctulata and its structural similarity to compound 2, docking calculations were performed for the interaction of both compounds with the human α1-β2-γ2 GABAA receptor. The results suggest that both compounds 1 and 2 must have affinity for the cavity at α1-γ2 interface
and support the development of pharmacological research on the compound verboccidentafuran 1 as a drug candidate for modulating the GABA/benzodiazepine complex in the central nervous system.
Survival of Folk Food in the Age of Digital Reproduction: A Study of Aditya Bal’s “Lost Recipes”
Authors:   Independent Research Scholar, Bhakat Mayuri , Paul Sudipta Kumar ,   T.G.T English, J.N.V. Barpeta, Assam
Published: November 2024

What we eat determines who we are; it draws an invisible boundary line between ‘us’ and ‘them’ as well as unites ‘us’ with ‘them’. Our cuisine and platters represent us even when Globalization claims to have erased the boundary between ‘us’ and ‘them.’ Traditionally, food is believed to be one of the intangible cultural capitals to trace the footprints of human life and community. In the quest to unearth the lost recipes of different communities and tribes in India, Chef Aditya Bal has travelled across the country and explored various lost flavours. All the episodes of “Lost Recipes” streaming on EPIC channel have been unearthing various lost recipes of our country and providing them wider viewers. Interestingly, this show has introduced some folk food habits along with royal recipes and recipes among a wider range of audience. ‘Seeda Roti’ from Garhwal, ‘Suski’ from Chattishgarh, ‘Fish Alberas’ by Bene Israelis, and Konkan’s ‘Katri’ – all these lost folk recipes lead us down memory lane through their rich aroma and taste. Excavating and documenting the history of folk life and their distinct platters, which are gradually being lost, this programme is helping the extinct cultural identities to revive.

Walter Benjamin’s idea of democratization of the work of art in the age of mechanical reproduction will be referred to re-read Aditya Bal’s ‘Lost Recipies’. How can folk culture be mediated to a universal audience while the aura remains unaffected? Does folk culture have an aura? Does democratization help folk culture in challenging the idea of ‘aura’? – these questions will be critically addressed in this paper within a limited circle of folk, food, and lost history of India.
Performance and mechanism of ‘coagulation co-adsorption’ on simultaneous reduction of turbidity and low-fluoride pollution by a polymer metal-based defluorination and turbidity-removal agent (PMDTA)
Authors: Fu Ying , Zheng Jiewen , Li Junhui , Wang Jie , Cheng Ming , Hang Qixin
Published: November 2024

A polymer metal-based defluorination and turbidity-removal agent (PMDTA) was prepared using a poly-Si–Fe coagulant (PSF) and aluminum. Simultaneous reduction of turbidity and fluoride by PMDTA was studied using the ‘coagulation co-adsorption (CcA)’ method for the simulated and real low-fluoride waters, respectively, compared with that by PSF. The surface and bond structures, charged properties, and size of PMDTA and its flocs were explored, and the mechanism of removing turbidity and fluoride was analyzed. The results showed PMDTA decreased fluoride to <1 mg/L (PSF could not), but both decreased turbidity to <0.5 NTU. PMDTA adapted to a wider initial turbidity, humid acid (HA), NaCl, and temperature. PMDTA had similar bond structures to PSF, more complex surface structures than PSF, and higher surface space and adsorption sites than PSF. Filtration had almost no impact on fluoride removal, but gave positive impact on turbidity removal. The removal mechanisms of fluoride and turbidity were different: the former was mainly removed through adsorption on PMDTA-flocs (controlled by their forming conditions) having efficient adsorption properties, and the latter was mainly cleared through a synergistic effect of the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory (classic coagulation mechanism). The efficient fluoride removal by PMDTA can fully utilize the existing facilities in water plants.
Os racismos nas legislações das federações de futebol sul-americanas: análise dos códigos de ética e regulamentos das primeiras divisões masculinas
Authors:   Universidade Federal de Minas Gerais, Ramos Danilo da Silva , Gomes Bernardo Jordano ,   Universidade Federal de Minas Gerais, Gomes André Silveira ,   Universidade Federal de Minas Gerais, Silva Alysson dos Anjos ,   Universidade Federal de Lavras
Published: November 2024

O presente artigo busca compreender como o racismo está sendo abordado pelas federações de futebol nos países da América do Sul. A partir de levantamento bibliográfico, foi possível notar que a discussão sobre o racismo no âmbito institucional desse esporte se mostra incipiente diante da significativa importância que essa temática carrega no atual contexto social. Como escolha metodológica delimitamos os doze países da América do Sul para o trabalho de campo, que foi realizado por meio de buscas documentais nas instituições regulamentadoras para posterior análise dos códigos de ética e os regulamentos de seus campeonatos das primeiras divisões masculinas. Como resultados, identificamos que existem diferenças no tratamento em cada federação/país e que há um conjunto de leis esportivas que visam variadas punições ao racismo no futebol. Algumas federações demonstraram notável avanço no combate ao racismo, ao passo que outras sequer o abordam em seus documentos oficiais. Acreditamos ser relevante salientar a necessidade de compreender de forma mais aprofundada como o racismo é tratado na realidade cotidiana do futebol nesses países, o que ressalta a importância de novos estudos se dedicarem a essa temática. Submissão: 13 ago. 2024 ⊶ Aceite: 21 out. 2024
Between Sartre and Ratzinger, or the Legacy of the “No Man’s” Revolution
Authors: Bańka Aleksander
Published: November 2024

This text analyses the relevance of the 1968 revolution in the context of the crisis of values in Western Europe and the response of Pope Benedict XVI to these challenges. The author shows that this revolution, inspired by Sartre’s existentialism and Marxism, had a profound impact on contemporary culture, challenging the traditional Christian understanding of man, God, and freedom. In response, Benedict XVI stressed the importance of a personal relationship with Jesus Christ as the foundation of an authentic faith, the only real alternative to the ideology of absolute freedom, and proposed Christianity as the path to true freedom, underpinned by the love of God.
Desempenho, característica de carcaça e da carne de cordeiros alimentados com silagem de sorgo com bagaço do caju
Authors:   , Barreto Hilton Felipe Marinho
Published: November 2024

O presente estudo objetivou avaliar os efeitos da substituição da forragem do sorgo pelo bagaço do caju desidratado no momento da ensilagem sobre o desempenho, características da carcaça e da carne de cordeiros confinados. Foram utilizados 32 ovinos machos, não castrados e mestiços das raças Morada Nova (½) e Santa Inês (½), com peso corporal inicial médio de 15,1±0,71 kg, confinados e com 14 dias de adaptação. A ração experimental foi composta por silagem confeccionada com 0; 8; 16 e 24% de bagaço de caju desidratado (BCD) em substituição a forragem de sorgo (Sorghum bicolor) no momento da ensilagem, ofertada em duas refeições diárias, sendo permitida uma sobra diária de, no máximo, 10%, sem nenhum fornecimento de suplementação concentrada. Foi determinada a composição química das silagens fornecidas, sobras e fezes, para determinação do consumo de matéria seca (CMS) e de nutrientes, e os respectivos coeficientes de digestibilidade, assim como foi mensurado o ganho de peso total (GPT) e diário (GPD) e conversão alimentar (CA). O abate dos animais ocorreu aos 120 dias de confinamento, sendo mensurados todos os componentes não integrantes da carcaça, o peso da carcaça quente (PCQ), peso da carcaça fria (PCF) e a perda por resfriamento (PPR). O pH foi aferido após o abate (pH0h) e o resfriamento (pH24h) no músculo Longissimus lumborum. Após resfriamento, a meia carcaça foi dividida em cinco partes (pescoço, paleta, costela, lombo e pernil) que foram pesadas individualmente, sendo o lombo separado para realização das análises de cor (Sistema CIE L* a* b*), capacidade da retenção de água (CRA), perda de peso na cocção (PPC), força de cisalhamento (FC), umidade, matéria mineral, proteína e lipídeos. O delineamento adotado foi inteiramente ao acaso, em que os dados foram submetidos à análise de variância e o efeito dos níveis de inclusão avaliados por meio de análise de regressão a 5% de significância. A substituição da forragem de sorgo pelo BCD permitiu a manutenção das características e da composição regional da carcaça, os pesos dos componentes não integrantes da carcaça e a qualidade da carne, favorecendo inclusive a produção de carnes com menores teores de lipídeos, ao serem utilizados níveis de 8 e 16% do bagaço de caju desidratado. Observou-se que os níveis de 8 e 16% de substituição da forragem de sorgo pelo bagaço de caju utilizados diminuíram o consumo de matéria seca e de nutrientes, e o ganho de peso total e diário. As silagens que continham BCD (8; 16 e 24%) promoveram melhoria na digestibilidade da matéria seca e dos nutrientes, em relação a silagem de sorgo (0%), e o uso da silagem que continha 24% de BCD promoveu o melhor resultado econômico entre as dietas testadas, sendo recomendada, portanto, a substituição de 24% da forragem de sorgo pelo BCD no momento da ensilagem
Vias alternativas de transmissão do Trypanosoma vivax em caprinos infectados experimentalmente
Authors:   , Bezerra Nicholas Morais
Published: November 2024

Considerando que algumas espécies de tripanossomatídeos são capazes de serem transmitidas por via sexual e pelo colostro. Estas vias de transmissão ainda não foram comprovadas na tripanossomose provocado por Trypanosoma vivax, o presente estudo teve como objetivos, pesquisar através da reação em cadeia da polimerase (PCR) a presença do DNA do T. vivax no sêmen de caprinos infectados experimentalmente, no colostro de cabras infectadas no terço final da gestação, investigar a possibilidade da transmissão em caprinos do parasita pela via sexual do macho para a fêmea e das cabras infectadas para bezerros saudáveis através da amamentação. No experimento para testar a transmissão sexual foram utilizados seis caprinos machos, os quais foram infectadas por via intravenosa com 0,5 ml de sangue contendo aproximadamente 1,25 × 105 tripomastigotas de T. vivax e seis caprinos machos que não foram infectados para serem um grupo controle. Foram coletadass de amostras de sêmen, para a pesquisa do DNA do T. vivax no sêmen através da realização do exame de reação em cadeia da polimerase (PCR). Seis cabras da raça saanen não infectadas por T. vivax foram acasaladas com os machos infectados. Para avaliar a transmissão do T. vivax pela via sexual, após o acasalamento as cabras foram submetidas a exames parasitológicos (esfregaço sanguíneo) e moleculares (PCR). No experimento para testar a transmissão pelo colostro foram usadas doze cabras da raça saanen, onde seis foram infectadas e seis foram usadas como controle, para observar a presença do DNA do parasita no colostro coletado após o parto, posteriormente o colostro foi ministrado para filhotes recém-nascidos de outras cabras saudáveis, depois os mesmos foram submetidos a exames parasitológicos e moleculares. A detecção do DNA de T. vivax (TviCatL-PCR) em amostras de sêmen pela técnica de PCR revelaram-se positivas em todos os animais e em todos períodos de observação. Também foi observado a presença do DNA do parasita em algumas amostras de colostro das cabras. Porém os resultados para as possibilidades da transmissão mostraram negativas tanto nas cabras cobertas do primeiro experimento como dos filhotes amamentados do segundo experimento. Apesar dos resultados negativos na transmissão, não podemos anular a possibilidade de transmissão sexual e pelo colostro já que outros fatores podem estar envolvidos
Efeitos da reposição volêmica com hidroxietilamido a 6% versus ringer com lactato após choque hemorrágico controlado em caprinos
Authors:   , Moreira Maria Alice Pires
Published: November 2024

Choque hemorrágico é uma importante causa de morte e tanto sua reversão quanto tratamento podem auxiliar pacientes, revertendo ou minimizando os efeitos deletérios desta condição. A perda significativa de volume intravascular provoca instabilidade hemodinâmica com diminuição da perfusão tecidual e hipoxia celular comprometendo gravemente as funções orgânicas. O uso de expansores volêmicos podem trazer benefícios e as substâncias sintéticas podem alterar o prognóstico e reverter o estado clínico em situações onde não há sangue nem doadores disponíveis. Ringer lactato e hidroxietilamido são soluções com características bioquímicas e moleculares vantajosas para serem utilizadas nos primeiros estágios do tratamento de choque hemorrágico; no entanto, mais estudos são necessários para determinar seus reais benefícios e efeitos deletérios. A avaliação da função cardíaca através da ecocardiografia auxilia na monitoração de pacientes com perda aguda de sangue sendo uma ferramenta essencial na prevenção e diagnóstico do choque. Nesse contexto, pesquisas são muitas vezes realizadas em pequenos ruminantes por serem considerados mais adequados para a avaliação clínica e elaboração de estratégias de tratamento e apesar da espécie caprina ser considerada um bom modelo experimental, dados relacionados à avaliação cardiovascular sob choque hemorrágico ainda são raros nesta espécie. Desta maneira, este estudo teve como objetivo descrever as características anatômicas e funcionais do coração de caprinos utilizando o exame ecocardiográfico transtorácico além de comparar os efeitos da reposição volêmica utilizando-se Hidroxietilamido a 6% e solução de Ringer com Lactato após choque hemorrágico experimental nesta espécie
Produção e capacidade de fitoextração do girassol (heliantus annus) irrigado com água produzida
Authors:   , Costa Fabrícia Gratyelli Bezerra
Published: November 2024

O presente trabalho objetivou analisar os efeitos da água produzida tratada no sistema produtivo da cultura do girassol. Para isso, foi montada uma área experimental em casa de vegetação, no Departamento de Ciências Agrárias e Florestais do Centro de Ciência Agrárias da Universidade Federal Rural do Semi-Árido. O experimento foi montado no delineamento em blocos casualizados com cinco tratamentos e cinco repetições. Os tratamentos utilizados foram T1 - 100% de aplicação água de abastecimento (AA) e 0% de água de produzida tratada (AP), T2 - 75% de AA e 25% de AP, T3 - 50% de AA e 50% de AP, T4 - 25% de AA e 75% de AP e T5 - 0% de AA e 100% de AP. No ensaio experimental foram utilizados vasos de 32L preenchidos com brita (nº zero) cobrindo a base dos mesmos e solo proveniente da Fazenda Experimental Rafael Fernandes em Mossoró, sendo classificado como Argissolo Vermelho Distrófico Típico. Todas as parcelas receberam adubação de fundação. Aos 90 dias após o transplantio foram avaliadas as características químicas do solo, onde se utilizou o esquema de parcelas subdivididas tendo nas parcelas os tratamentos, nas subparcelas as profundidades de amostragem (0 a 0,10 m; 0,20 a 0,30 m). A caracterização físico-química da água produzida e da água de abastecimento, foi realizada mensalmente por meio da coleta de três amostras durante o período experimental. Para a produtividade, características agronômicas, composição química das folhas, fatores de translocação e bioacumulação foram analisados os efeitos dos tratamentos. Os dados foram submetidos à análise de variância, testes de média e contrastes ortogonais. Entre os atributos físico-químicos monitorado no solo, apenas os teores de Mg2+ aumentaram, significamente, com as diluições de água produzida tratada, porém, deve enfatizar o relevante conteúdo de Na+ e Cl-1 na água produzida tratada, que pode limitar a utilização desta água para irrigação, devido aos riscos de sodificação do solo e de fitotoxicidades à cultura, principalmente se for aplicada via sistema de irrigação por aspersão.Os efeitos da água produzida tratada no solo após o cultivo do girassol foram favoráveis quanto ao fornecimento e à disponibilidade de nutrientes. Além disso valores de pH superiores a 7,50 na água produzida tratada e de 8,0 no solo, minimizam os riscos ambientais dos metais pesados. Não houve efeito negativo causado pela água produzida tratada nas características biométricas agronômicas do girassol. Inclusive o diâmetro de capítulo do girassol apresentou aumento significativo com o uso das diluições de água produzida tratada. O girassol apresentou eficiência na translocação de Na e bioacumulação de Mn, Zn, Cr, Ni e Pb. Para aprimorar os conhecimentos sobre o uso sustentável da água produzida para fins agrícolas, recomenda-se a realização de estudos complementares sobre os efeitos dos hidrocarbonetos, fenóis e outros metais pesados no sistema solo-planta
Navigating the Complex Interplay: Gut Microbiome and Human Health
Authors: Shukla Ajay Kumar , Mishra Manoj Kumar , Tiwari Aarti
Published: November 2024

The gut microbiome plays a pivotal role in human health, influencing various physiological processes and overall well-being. Firstly, we explore
dietary components such as prebiotics, probiotics, and fermented foods, which can modulate the composition and diversity of gut microbiota,
thereby promoting a balanced microbial community. Additionally, lifestyle factors including exercise, stress management, and sleep patterns are
discussed for their significant influence on gut microbiome stability and functionality. Dietary polyphenols have the ability to alter the make-up
and activities of gut flora, which in turn affects immunity, inflammation, and gut metabolism. Numerous methods have been developed to increase
the solubility, transport, and targeted administration of dietary polyphenols throughout the gastrointestinal tract in order to enhance their
bioavailability. While further investigation is necessary, particularly in the form of translational and clinical trials, new developments in
biotechnology present encouraging opportunities to use dietary polyphenols to influence the gut microbiota in dysbiosis-related illnesses. This
overview provides insights into the dynamic relationship between factors affecting the gut microbiome's fundamental characteristics, the impact of
diet on gut microbial ecology, the relationship between infectious diseases and the gut microbiota, and the potential of dietary polyphenols in
controlling the gut microbiome. It underscores the importance of fostering a symbiotic microbial ecosystem for overall well-being.
Evaluation of the Effects of Guizhi Shaoyao Zhimu Decoction on Rheumatoid Arthritis by Ultrasound Combined with Electrophysiological Examination
Authors: Shi Miao , Li Xin , Yuan Min , Chen Feng , Xu Lishan , Pan Xiaojie , Lv Baowei , Teng Jianbo
Published: November 2024

Background:

Guizhi Shaoyao Zhimu Decoction can be used in the treatment of rheumatoid arthritis, but there is scarce literature on using ultrasound combined
with electrophysiology to evaluate the efficacy of this traditional Chinese medicine.

Aim:

This study aimed to explore the clinical effect of Guizhi Shaoyao Zhimu decoction on cold-dampness arthralgia rheumatoid arthritis (RA) by
ultrasound and electrophysiological examination.

Methods:

A total of 64 patients with rheumatoid arthritis were randomly divided into two groups, with 32 cases in each group. The control group was treated
with conventional western medicine, and the experimental group was treated with Guizhi Shaoyao Zhimu Decoction in addition to conventional
western medicine. After 4 weeks of treatment, traditional Chinese medicine (TCM) symptom scores, erythrocyte sedimentation rate (ESR), Creactive
protein (CRP), 28 joint disease range of motion score (DAS28), ultrasonic score, and electrophysiological examination results were
observed.

Results:

There were significant differences in TCM syndrome scores, ESR, CRP, DAS28, and ultrasound scores in the two groups before and after
treatment (P<0.05). Compared between the two groups after treatment, there were statistically significant differences in TCM syndrome scores,
ESR, CRP, DAS28, and ultrasound scores (P<0.05). The motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV),
and action potential (AP) of the median nerve and ulnar nerve in the experimental group were significantly increased compared with the control
group (P<0.05).

Conclusions:

Guizhi Shaoyao Zhimu Decoction combined with conventional western medicine has a significant effect on cold-dampness arthralgia rheumatoid
arthritis, and ultrasound and electrophysiological examination can be used to evaluate its curative effect.
Upregulation of LncRNA WT1-AS Inhibits Tumor Growth and Promotes Autophagy in Gastric Cancer via Suppression of PI3K/Akt/mTOR Pathway
Authors: Zhang Xiaobei , Jin Meng , Yao Xiaoying , Liu Jilan , Yang Yonghong , Huang Jian , Jin Guiyuan , Liu Shiqi , Zhang Baogui
Published: November 2024

Background:

Increasing evidence has highlighted the involvement of the imbalance of long non-coding RNAs in the development of gastric cancer (GC), which
is one of the most common malignancies in the world. This study aimed to determine the role of lncRNA WT1-AS in the progression of GC and
explore its underlying mechanism.

Methods:

The expression of lncRNA WT1-AS in gastric cancer tissues was detected using RT-qPCR. We knocked down the expression of WT1-AS in GC
cells or treated them with rapamycin or both. Then, transwell assay and scratch assay were carried out to determine the migration of GC cells, and
flow cytometry was carried out to determine the cell cycle. The immunofluorescence technique was used to determine the autophagy, and a tumor
formation experiment was carried out to determine tumor growth in vivo. The expression of factors related to the PI3K/Akt/mTOR pathway was
also measured by Western Blotting.

Results:

In GC tissues and cells, lncRNA WT1-AS was underexpressed. Moreover, overexpression of lncRNA WT1-AS blocked the PI3K/Akt/mTOR
pathway. Upregulation of lncRNA WT1-AS or inhibition of the PI3K/Akt/mTOR pathway suppressed cancer cell migration in vitro, leading to cell
cycle arrest, and promoted autophagy while inhibiting tumor growth in vivo. It also reduced the expression levels of Ki-67, MMP2, MMP9, and
VEGF. The WT1-AS+rapamycin group was the most prominent in all experiments.

Conclusion:

The upregulation of lncRNA WT1-AS could suppress the PI3K/Akt/mTOR pathway, which inhibits cell migration and cell cycle arrest while
promoting autophagy in gastric cancer cells.
Renal Resistive Index as A Early Predictor of Renal Dysfunction in Patients with Type 2 Diabetes Mellitus
Authors: Dsouza Amith Vijay Leon , D'Souza Reshmina , Adiga K Prashanth , Braggs Anston
Published: November 2024

Background : Type 2 diabetes develops over a long period of time, represents 85–90 per cent of all cases of diabetes . Diabetic nephropathy is a relatively common form of chronic renal disease. It is the most constant microvascular complication in diabetic patients.Conventional ultrasound and colour Doppler provide easily available, affordable and non-invasive follow up method for evaluation of kidneys in diabetic nephropathy.
Aim :The purpose of this study is to assess the intrarenal resistivity index by Doppler ultrasonography in a group of diabetics with normal renal function in comparison to non diabetic controls and correlating them with biochemical parameters.
Materials And Methods :The study was done over a period of 2 years from October 2020 To October 2022. The study I a case control study we evaluated the intra-renal hemodynamic changes with Doppler sonography in diabetic patients in comparison to non-diabetic controls,  All the data was expressed as mean + SD. Differences between the two groups was analysed by t test and chi-square test. Categorical data expressed as frequency and percentages.
Results And Observations The mean age in the diabetic group was 58.84 years SD + 15.61 years and age - non diabetic group was 56.66 years SD + 14.09 years . there was a negative correlation between age and diabetes mellitus with nephropathy , p > 0.0784 r -.026  A  significant the correlation of the Mean  resistivity index RI of the right kidney at the hilum was 0.63  the correlation was positive that is the resistance increased in diabetes mellitus as compared to non diabetic and this was significant with a  p value 0 .049 significant . All the resistive indices were higher in the diabetic than the non diabetic individuals , the highest being in the midpole and it was statistically significant at all places in both kidneys with a p value <0.05.
Conclusion :The renal Doppler indices are good indices to evaluate the renal dysfunction in the early stages. In this study, the blood sugar levels of all cases were at least moderately controlled, yet the renal indices showed gross anomaly even though the creatinine clearance was well above normal limits.