bluuebunny/crossref_metadata_2025 huggingface dataset:
In Operando Angle‐Resolved Photoemission Spectroscopy with Nanoscale Spatial Resolution: Spatial Mapping of the Electronic Structure of Twisted Bilayer Graphene
Authors: Majchrzak Paulina , Muzzio Ryan , Jones Alfred J. H. , Curcio Davide , Volckaert Klara , Biswas Deepnarayan , Gobbo Jacob , Singh Simranjeet , Robinson Jeremy T. , Watanabe Kenji , Taniguchi Takashi , Kim Timur K. , Cacho Cephise , Miwa Jill A. , Hofmann Philip , Katoch Jyoti , Ulstrup Søren
Published: March 2021

To pinpoint the electronic and structural mechanisms that affect intrinsic and extrinsic performance limits of 2D material devices, it is of critical importance to resolve the electronic properties on the mesoscopic length scale of such devices under operating conditions. Herein, angle‐resolved photoemission spectroscopy with nanoscale spatial resolution (nanoARPES) is used to map the quasiparticle electronic structure of a twisted bilayer graphene device. The dispersion and linewidth of the Dirac cones associated with top and bottom graphene layers are determined as a function of spatial position on the device under both static and operating conditions. The analysis reveals that microscopic rotational domains in the two graphene layers establish a range of twist angles from 9.8° to 12.7°. Application of current and electrostatic gating lead to strong electric fields with peak strengths of 0.75 V/μm at the rotational domain boundaries in the device. These proof‐of‐principle results demonstrate the potential of nanoARPES to link mesoscale structural variations with electronic states in operating device conditions and to disentangle such extrinsic factors from the intrinsic quasiparticle dispersion.
Silver‐Promoted High‐Performance (Ag,Cu)(In,Ga)Se2 Thin‐Film Solar Cells Grown at Very Low Temperature
Authors: Yang Shih-Chi , Sastre Jordi , Krause Maximilian , Sun Xiaoxiao , Hertwig Ramis , Ochoa Mario , Tiwari Ayodhya N. , Carron Romain
Published: March 2021

Achieving high power conversion efficiencies with Cu(In,Ga)Se2 (CIGS) solar cells grown at low temperature is challenging because of insufficient thermal energy for grain growth and defect annihilation, resulting in poor crystallinity, higher defect concentration, and degraded device performance. Herein, the possibilities for high‐performing devices produced at very low temperatures (≤450 °C) are explored. By alloying CIGS with Ag by the precursor layer method, (Ag,Cu)(In,Ga)Se2 (ACIGS) solar cells grown at about 450 °C reach an efficiency of 20.1%. Only a small efficiency degradation (0.5% and 1.6% absolute) is observed for ACIGS absorbers deposited at 60 and 110 °C lower substrate temperature. CIGS devices exhibit a stronger efficiency degradation, driven by a decrease in the open‐circuit voltage (). The root cause of the difference between ACIGS and CIGS devices is investigated by advanced characterization techniques, which show improved morphology, reduced tail states, and higher doping density in ACIGS absorbers. The proposed approach offers several benefits in view of depositions on temperature‐sensitive substrates. Increased Cu diffusion promoted by Ag allows end‐point detection in the three‐stage process at the substrate temperatures below 300 °C. The modified process requires minimal modification of existing processes and equipment and shows the potential for the use of different flexible substrates and device architectures.
Effect of micro‐structural changes on concrete properties at elevated temperature: Current knowledge and outlook
Authors: Pulkit Umang , Adhikary Satadru Das
Published: March 2021

The influence of microstructural changes on concrete properties at elevated temperatures is presented and discussed in this paper, as the exposure to elevated temperatures brings in marked changes in concrete thermal, mechanical and kinematic properties owing to the heat‐induced evolution of material's microstructure. The major microstructural changes consist in increasing pore size, occurrence of microcracking and activation of chemo‐physical processes in the hardened cement‐paste. These processes (like portlandite dissociation and crystalline change in quartzitic aggregate) occur above 400°C and are more pronounced in high‐strength than in normal‐strength concrete. Increasing pore size and microcracking, however, yield the largest contribution to concrete strength‐loss, that occurs mainly between 400 and 800°C, depending on aggregate type and initial moisture content in the mix. On the whole, calcareous (or carbonate) aggregate behaves better than siliceous aggregate face to increasing temperatures. Initial moisture content favors concrete thermal spalling, mostly between 200 and 400°C, but such a complex phenomenon is still open to investigation, as demonstrated by the various theories found in the literature, each with its chemo‐physical mechanisms and limitations. Three theories are discussed in this paper, and these theories together with other critical issues allow to focus on future work.
Genetic assessment of captive red pandas (Ailurus fulgens) in American zoos to address management separation by putative subspecies
Authors: Dueck Lucy A.
Published: March 2021

Red pandas (Ailurus fulgens) are small charismatic mammals native across montane southern Asia, now endangered by human impacts. They are considered “living fossils” as the sole member of a distinct family, warranting higher conservation priority. Therefore, ex situ breeding programs were initiated to prevent extinction and act as genetic reservoirs for reintroduction, although complicated by apparent taxonomic subdivision. This study investigated whether the separation of captive red pandas in the North American Species Survival Plan® by putative subspecies was justified. A 383‐bp segment of mitochondrial DNA control region was therefore sequenced from 67 members representing matriarchal lineages of both groups. A network analysis placed the 11 haplotypes found into separate but closely connected clusters, with one group more strongly related than the other. Statistical analyses and diversity indices corroborated differentiation between the two management units. Phylogenetic analyses employing multiple outgroups confirmed, although not robustly, reciprocal monophyly of the four‐ and seven‐haplotype clades representing putative subspecies Ailurus fulgens fulgens and Ailurus fulgens styani, respectively. These empirical results are adequate to justify continued independent management of these zoo subpopulations, but cannot be definitive for taxonomic classification due to limited sampling from their native range. They will, however, be useful in evaluating long‐term genetic diversity changes, focusing management efforts on newly revealed evolutionary limitations, and comparing with an assessment of wild red pandas to determine how representative zoo populations are for reintroduction purposes. Maintaining genetic diversity and population structure of endangered species is essential to protect evolutionary potential and adaptations for long‐term sustainability.
Unruh detectors and quantum chaos in JT gravity
Authors: Blommaert Andreas , Mertens Thomas G. , Verschelde Henri
Published: March 2021

Abstract

We identify the spectral properties of Hawking-Unruh radiation in the eternal black hole at ultra low energies as a probe for the chaotic level statistics of quantum black holes. Level repulsion implies that there are barely Hawking particles with an energy smaller than the level separation. This effect is experimentally accessible by probing the Unruh heat bath with a linear detector. We provide evidence for this effect via explicit and exact calculations in JT gravity building on a radar definition of bulk observables in the model. Similar results are observed for the bath energy density. This universal feature of eternal Hawking radiation should resonate into the evaporating setup.
Quantum spin systems and supersymmetric gauge theories. Part I
Authors: Lee Norton , Nekrasov Nikita
Published: March 2021

Abstract

The relation between supersymmetric gauge theories in four dimensions and quantum spin systems is exploited to find an explicit formula for the Jost function of the N site $$ \mathfrak{sl} $$
sl
2X X X spin chain (for infinite dimensional complex spin representations), as well as the SLN Gaudin system, which reduces, in a limiting case, to that of the N-particle periodic Toda chain. Using the non-perturbative Dyson-Schwinger equations of the supersymmetric gauge theory we establish relations between the spin chain commuting Hamiltonians with the twisted chiral ring of gauge theory. Along the way we explore the chamber dependence of the supersymmetric partition function, also the expectation value of the surface defects, giving new evidence for the AGT conjecture.
Publisher Correction to: On the stochastic Dullin–Gottwald–Holm equation: global existence and wave-breaking phenomena
Authors: Rohde Christian , Tang Hao
Published: March 2021

During the typesetting process, some misprints have been introduced in the original publication of the article.
Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide
Authors: Krischak Alexander , Kowaliuk Jakob , Sarsarshahi Sina , Dörr Wolfgang , Kleiter Miriam
Published: March 2021

Purpose

In a previous study we have shown in a mouse model that administration of nuclear factor-kappa B (NF-κB) inhibitor thalidomide has promising therapeutic effects on early radiation cystitis (ERC) and late radiation sequelae (LRS) of the urinary bladder. The aim of this study was to evaluate in the same mice the effect of thalidomide on adherens junction (AJ) proteins in ERC and LRS.

Methods

Urothelial expressions of E‑cadherin and β‑catenin were assessed by immunohistochemistry in formalin-fixed paraffin-embedded (FFPE) bladder specimens over 360 days post single-dose irradiation on day 0. First, the effect of irradiation on AJ expression and then effects of thalidomide on irradiation-induced AJ alterations were assessed using three different treatment times.

Results

Irradiation provoked a biphasic upregulation of E‑cadherin and β‑catenin in the early phase. After a mild decrease of E‑cadherin and a pronounced decrease of β‑catenin at the end of the early phase, both increased again in the late phase. Early administration of thalidomide (day 1–15) resulted in a steeper rise in the first days, an extended and increased expression at the end of the early phase and a higher expression of β‑catenin alone at the beginning of the late phase.

Conclusion

Upregulation of AJ proteins is an attempt to compensate irradiation-induced impairment of urothelial barrier function. Early administration of thalidomide improves these compensatory mechanisms by inhibiting NF-κB signaling and its interfering effects.
Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system
Authors: Gangnus Tanja , Burckhardt Bjoern B.
Published: March 2021

The kallikrein-kinin system (KKS) is involved in many physiological and pathophysiological processes and is assumed to be connected to the development of clinical symptoms of angioedema or COVID-19, among other diseases. However, despite its diverse role in the regulation of physiological and pathophysiological functions, knowledge about the KKS in vivo remains limited. The short half-lives of kinins, their low abundance and structural similarities and the artificial generation of the kinin bradykinin greatly hinder reliable and accurate determination of kinin levels in plasma. To address these issues, a sensitive LC-MS/MS platform for the comprehensive and simultaneous determination of the four active kinins bradykinin, kallidin, des-Arg(9)-bradykinin and des-Arg(10)-kallidin and their major metabolites bradykinin 2-9, bradykinin 1-7 and bradykinin 1-5 was developed. This platform was validated according to the bioanalytical guideline of the US Food and Drug Administration regarding linearity, accuracy, precision, sensitivity, carry-over, recovery, parallelism, matrix effects and stability in plasma of healthy volunteers. The validated platform encompassed a broad calibration curve range from 2.0–15.3 pg/mL (depending on the kinin) up to 1000 pg/mL, covering the expected concentrations in disease states. No source-dependent matrix effects were identified, and suitable stability of the analytes in plasma was observed. The applicability of the developed platform was proven by the determination of endogenous levels in healthy volunteers, whose plasma kinin levels were successfully detected in the low pg/mL range. The established platform facilitates the investigation of kinin-mediated diseases (e.g. angioedema, COVID-19) and enables the assessment of the impact of altered enzyme activities on the formation or degradation of kinins.

Graphical abstract
Time dependent asymptotic analysis of the gene regulatory network of the AcrAB-TolC efflux pump system in gram-negative bacteria
Authors: Youlden George H. , Ricci Vito , Wang-Kan Xuan , Piddock Laura J. V. , Jabbari Sara , King John R.
Published: March 2021

Efflux pumps are a mechanism of intrinsic and evolved resistance in bacteria. If an efflux pump can expel an antibiotic so that its concentration within the cell is below a killing threshold the bacteria are resistant to the antibiotic. Efflux pumps may be specific or they may pump various different substances. This is why many efflux pumps confer multi drug resistance (MDR). In particular over expression of the AcrAB−TolC efflux pump system confers MDR in bothSalmonellaandEscherichia coli. We consider the complex gene regulation network that controls expression of genes central to controlling the efflux associated genesacrABandacrEFinSalmonella. We present the first mathematical model of this gene regulatory network in the form of a system of ordinary differential equations. Using a time dependent asymptotic analysis, we examine in detail the behaviour of the efflux system on various different timescales. Asymptotic approximations of the steady states provide an analytical comparison of targets for efflux inhibition.
Feasibility and Safety of Office-Based Transnasal Balloon Dilation for Neopharyngeal and Proximal Esophageal Strictures in Patients with a History of Head and Neck Carcinoma
Authors: Schimberg Anouk S. , Wellenstein David J. , Schutte Henrieke W. , Honings J. , Marres Henri A. M. , Takes Robert P. , van den Broek Guido B.
Published: March 2021

The aim of this study was to assess feasibility and safety of office-based transnasal balloon dilation of neopharyngeal and proximal esophageal strictures in patients with a history of head and neck carcinoma. The secondary objective was to explore its effectiveness. This prospective case series included patients previously treated for head and neck carcinoma with neopharyngeal or proximal esophageal strictures who underwent transnasal balloon dilation under topical anesthesia. The target dilation diameter was 15 mm; if necessary dilation procedures were repeated every 2–4 weeks until this target was reached. Completion rates, adverse events, and patient experiences measured by VAS scores (0 = no complaints – 10 = unbearable complaints), dysphagia scores based on food consistency (0 = no dysphagia – 5 = unable to swallow liquids/saliva), and self-reported changes in swallowing symptoms were recorded. Follow-up was 2 months. Twenty-six procedures were performed in 12 patients, with a completion rate of 92%. One minor complication occurred, i.e. an infection of the dilation site. Tolerance of the procedure was good (median VAS = 2). The dysphagia score improved after a mean of 2.2 procedures per patient, however not significantly. Eight patients reported improvement in dysphagia, of whom 3 had recurrence of dysphagia within 1 month post-treatment. Office-based transnasal balloon dilation is a feasible and safe in-office procedure which is well-tolerated by patients. The dilations can improve dysphagia, although effects might be transient.
Stress Drop, Seismogenic Index and Fault Cohesion of Fluid-Induced Earthquakes
Authors: Shapiro Serge A. , Dinske Carsten
Published: March 2021

Sometimes, a rather high stress drop characterizes earthquakes induced by underground fluid injections or productions. In addition, long-term fluid operations in the underground can influence a seismogenic reaction of the rock per unit volume of the fluid involved. The seismogenic index is a quantitative characteristic of such a reaction. We derive a relationship between the seismogenic index and stress drop. This relationship shows that the seismogenic index increases with the average stress drop of induced seismicity. Further, we formulate a simple and rather general phenomenological model of stress drop of induced earthquakes. This model shows that both a decrease of fault cohesion during the earthquake rupture process and an enhanced level of effective stresses could lead to high stress drop. Using these two formulations, we propose the following mechanism of increasing induced seismicity rates observed, e.g., by long-term gas production at Groningen. Pore pressure depletion can lead to a systematic increase of the average stress drop (and thus, of magnitudes) due to gradually destabilizing cohesive faults and due to a general increase of effective stresses. Consequently, elevated average stress drop increases seismogenic index. This can lead to seismic risk increasing with the operation time of an underground reservoir.
Three-dimensional modeled environments versus 360 degree panoramas for mobile virtual reality training
Authors: Ritter K. A. , Chambers Terrence L.
Published: March 2021

Virtual field trip is a way of providing users with some knowledge and exposure of a facility without requiring them to physically visit the location. Due to the high computational costs that are necessary to produce virtual environments (VEs), the potential for photorealism is sacrificed. Often these three-dimensional (3D) modeled applications use an unrealistic VE and, therefore, do not provide a full depiction of real-world environments. Panoramas can be used to showcase complex scenarios that are difficult to model and are computationally expensive to view in virtual reality (VR). Utilizing 360° panoramas can provide a low-cost and quick-to-capture alternative with photorealistic representations of the actual environment. The advantages of photorealism over 3D models for training and education are not clearly defined. This paper initially summarizes the development of a VR training application and initial pilot study. Quantitative and qualitative study then was conducted to compare the effectiveness of a 360° panorama VR training application and a 3D modeled one. Switching to a mobile VR headset saves money, increases mobility, decreases set-up and breakdown time, and has less spatial requirements. Testing results of the 3D modeled VE group had an average normalized gain of 0.03 and the 360° panorama group, 0.43. Although the 3D modeled group had slightly higher realism according to the presence questionnaire and had slightly higher averages in the comparative analysis questionnaire, the 360° panorama application has shown to be the most effective for training and the quickest to develop.
The New Normal: Coronavirus Pandemic Response Utilizing Microsoft SharePoint
Authors: Hiti Corey J. , Chang Jennifer , Gwal Kriti , Escobedo Eva , Rea Margaret , Bindra Jasjeet
Published: March 2021

On March 11, 2020, the World Health Organization (WHO) declared the novel coronavirus disease (COVID-19) a pandemic. Hospitals throughout the USA and the residency programs housed therein have drastically altered their standard operations to slow the spread of disease. Maintaining the educational mission of a residency program within the parameters of social distancing mandates is an unprecedented challenge to graduate medical education and will remain so for the near future. We evaluated resident perception of our efforts to transition educational activities within the residency to an online, remote format utilizing Microsoft SharePoint. Educational conferences were transitioned to a videoconferencing platform on March 13, 2020 in conjunction with the deployment of an intradepartmental Microsoft SharePoint site to provide educational resources, disseminate scheduling changes, and provide wellness resources in response to the COVID-19 pandemic. An 11-question survey available from 4 Jan 2020–4 Jun 2020 surveyed resident perceptions of the instituted changes. Twenty-six of 31 residents (83.8%) responded to the resident survey invitation. Twenty-four of 26 residents (92.3%) characterized the SharePoint as useful. Twenty of 26 residents (76.9%) desired attending guidance as to how to utilize the online resources for each resident rotation. A total of 92.3% (24/26) of residents felt that the program’s response utilizing SharePoint engendered a greater sense of belonging to their work community. Resident perception of the transition to online learning utilizing Microsoft SharePoint as a distribution platform was generally positive, helping to mitigate untoward educational consequences of the COVID-19 pandemic.
Supporting Virtual Dermatology Consultation in the Setting of COVID-19
Authors: Kutner Allison , Love Danielle , Markova Alina , Rossi Anthony , Lee Erica , Nehal Kishwer , Lacouture Mario , Rotemberg Veronica
Published: March 2021

While telemedicine has been utilized with more frequency over the past two decades, there remained significant barriers to its broad implementation. The COVID-19 global pandemic served as a stimulus for rapid expansion and implementation of telemedicine services across medical institutions worldwide in order to maximize patient care delivery, minimize exposure risk among healthcare providers and patients alike, and avoid overcrowding of patient care facilities. In this experience report, we highlight the teledermatology initiatives executed by the Dermatology Service at Memorial Sloan Kettering Cancer Center in New York City, with particular emphasis on image ingestion and potential for future automation and improvement.
Conditional local recurrence risk: the effect of event-free years in different subtypes of breast cancer
Authors: Moossdorff M. , Vane Marissa L. G. , van Nijnatten T. J. A. , van Maaren M. C. , Goorts B. , Heuts E. M. , Strobbe L. J. A. , Smidt M. L.
Published: March 2021

Background

After breast cancer treatment, follow-up consists of physical examination and mammography for at least 5 years, to detect local and regional recurrence. The risk of recurrence may decrease after event-free time. This study aims to determine the risk of local recurrence (LR) as a first event until 5 years after diagnosis, conditional on being event-free for 1, 2, 3 and 4 years.

Methods

From the Netherlands Cancer Registry, all M0 breast cancers diagnosed between 2005 and 2008 were included. LR risk was calculated with Kaplan–Meier analysis, overall and for different subtypes. Conditional LR (assuming x event-free years) was determined by selecting event-free patients at x years, and calculating their LR risk within 5 years after diagnosis.

Results

Five-year follow-up was available for 34,453 patients. Overall, five-year LR as a first event occurred in 3.0%. This risk varied for different subtypes and was highest for triple negative (6.8%) and lowest for ER+PR+Her2− (2.2%) tumors. After 1, 2, 3 and 4 event-free years, the average risk of LR before 5 years after diagnosis decreased from 3.0 to 2.4, 1.6, 1.0, and 0.6%. The risk decreased in all subtypes, the effect was most pronounced in subtypes with the highest baseline risk (ER−Her2+ and triple negative breast cancer). After three event-free years, LR risk in the next 2 years was 1% or less in all subtypes except triple negative (1.6%).

Conclusion

The risk of 5-year LR as a first event was low and decreased with the number of event-free years. After three event-free years, the overall risk was 1%. This is reassuring to patients and also suggests that follow-up beyond 3 years may produce low yield of LR, both for individual patients and studies using LR as primary outcome. This can be used as a starting point to tailor follow-up to individual needs.
Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines
Authors: Yi Jae-Sung , Perla Sravan , Huang Yan , Mizuno Kana , Giordano Frank J. , Vinks Alexander A. , Bennett Anton M.
Published: March 2021

Purpose

Noonan syndrome with multiple lentigines (NSML) is an autosomal dominant disorder presenting with hypertrophic cardiomyopathy (HCM). Up to 85% of NSML cases are caused by mutations in the PTPN11 gene that encodes for the Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2). We previously showed that low-dose dasatinib protects from the development of cardiac fibrosis in a mouse model of NSML harboring a Ptpn11Y279C mutation. This study is performed to determine the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a low-dose of dasatinib in NSML mice and to determine its effectiveness in ameliorating the development of HCM.

Methods

Dasatinib was administered intraperitoneally into NSML mice with doses ranging from 0.05 to 0.5 mg/kg. PK parameters of dasatinib in NSML mice were determined. PD parameters were obtained for biochemical analyses from heart tissue. Dasatinib-treated NSML mice (0.1 mg/kg) were subjected to echocardiography and assessment of markers of HCM by qRT-PCR. Transcriptome analysis was performed from the heart tissue of low-dose dasatinib-treated mice.

Results

Low-dose dasatinib exhibited PK properties that were linear across doses in NSML mice. Dasatinib treatment of between 0.05 and 0.5 mg/kg in NSML mice yielded an exposure-dependent inhibition of c-Src and PZR tyrosyl phosphorylation and inhibited AKT phosphorylation. We found that doses as low as 0.1 mg/kg of dasatinib prevented HCM in NSML mice. Transcriptome analysis identified differentially expressed HCM-associated genes in the heart of NSML mice that were reverted to wild type levels by low-dose dasatinib administration.

Conclusion

These data demonstrate that low-dose dasatinib exhibits desirable therapeutic PK properties that is sufficient for effective target engagement to ameliorate HCM progression in NSML mice. These data demonstrate that low-dose dasatinib treatment may be an effective therapy against HCM in NSML patients.
Viscoelastic phase-field fracture using the framework of representative crack elements
Authors: Yin Bo , Storm Johannes , Kaliske Michael
Published: March 2021

The promising phase-field method has been intensively studied for crack approximation in brittle materials. The realistic representation of material degradation at a fully evolved crack is still one of the main challenges. Several energy split formulations have been postulated to describe the crack evolution physically. A recent approach based on the concept of representative crack elements (RCE) in Storm et al. (The concept of representative crack elements (RCE) for phase-field fracture: anisotropic elasticity and thermo-elasticity. Int J Numer Methods Eng 121:779–805, 2020) introduces a variational framework to derive the kinematically consistent material degradation. The realistic material degradation is further tested using the self-consistency condition, which is particularly compared to a discrete crack model. This work extends the brittle RCE phase-field modeling towards rate-dependent fracture evolution in a viscoelastic continuum. The novelty of this paper is taking internal variables due to viscoelasticity into account to determine the crack deformation state. Meanwhile, a transient extension from Storm et al. (The concept of representative crack elements (RCE) for phase-field fracture: anisotropic elasticity and thermo-elasticity. Int J Numer Methods Eng 121:779–805, 2020) is also considered. The model is derived thermodynamic-consistently and implemented into the FE framework. Several representative numerical examples are investigated, and consequently, the according findings and potential perspectives are discussed to close this paper.
Metaphor Comprehension in Individuals with Autism Spectrum Disorder: Core Language Skills Matter
Authors: Kalandadze Tamara , Braeken Johan , Brynskov Cecilia , Næss Kari-Anne Bottegaard
Published: March 2021

Poor metaphor comprehension was considered a hallmark of autism spectrum disorder (ASD), but recent research has questioned the extent and the sources of these difficulties. In this cross-sectional study, we compared metaphor comprehension in individuals with ASD (N = 29) and individuals with typical development (TD; N = 31), and investigated the relationship between core language and metaphor comprehension. Individuals with ASD showed more difficulty but also a more variable performance in both metaphor and literal items of the task used than individuals with TD did. This indicates that core language ability accounts for metaphor comprehension and should be considered in future research and interventions aiming to improve metaphor comprehension in individuals with ASD.
Four propositions on integrated sustainability: toward a theoretical framework to understand the environment, peace, and sustainability nexus
Authors: Fisher Joshua , Arora Poonam , Chen Siqi , Rhee Sophia , Blaine Tempest , Simangan Dahlia
Published: March 2021

The sustainability agenda has evolved around a set of interconnected dilemmas regarding economic, social, and environmental goals. Progress has been made in establishing thresholds and targets that must be achieved to enable life to continue to thrive on the planet. However, much work remains to be done in articulating coherent theoretical frameworks that adequately describe the mechanisms through which sustainability outcomes are achieved. This paper reviews core concepts in the sustainability agenda to develop four propositions on integrated sustainability that collectively describe the underlying mechanisms of sustainable development. We then advance a framework for integrated sustainability and assess its viability through linear regression and principal components analysis of key selected indicators. The results provide preliminary evidence that countries with institutions that enable cooperation and regulate competition perform better in attaining integrated sustainability indicators. Our findings suggest that institutional design is important to sustainability outcomes and that further research into process-oriented mechanisms and institutional characteristics can yield substantial dividends in enabling effective sustainability policy.
In-Situ High-Energy X-ray Diffraction Study of Austenite Decomposition During Rapid Cooling and Isothermal Holding in Two HSLA Steels
Authors: Lin Sen , Borggren Ulrika , Stark Andreas , Borgenstam Annika , Mu Wangzhong , Hedström Peter
Published: March 2021

In-situ high-energy X-ray diffraction experiments with high temporal resolution during rapid cooling (280 °C s−1) and isothermal heat treatments (at 450 °C, 500 °C, and 550 °C for 30 minutes) were performed to study austenite decomposition in two commercial high-strength low-alloy steels. The rapid phase transformations occurring in these types of steels are investigated for the first time in-situ, aiding a detailed analysis of the austenite decomposition kinetics. For the low hardenability steel with main composition Fe-0.08C-1.7Mn-0.403Si-0.303Cr in weight percent, austenite decomposition to polygonal ferrite and bainite occurs already during the initial cooling. However, for the high hardenability steel with main composition Fe-0.08C-1.79Mn-0.182Si-0.757Cr-0.094Mo in weight percent, the austenite decomposition kinetics is retarded, chiefly by the Mo addition, and therefore mainly bainitic transformation occurs during isothermal holding; the bainitic transformation rate at the isothermal holding is clearly enhanced by lowered temperature from 550 °C to 500 °C and 450 °C. During prolonged isothermal holding, carbide formation leads to decreased austenite carbon content and promotes continued bainitic ferrite formation. Moreover, at prolonged isothermal holding at higher temperatures some degenerate pearlite form.
Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement
Authors: Cici Daniela , Corrado Addolorata , Rotondo Cinzia , Colia Ripalta , Cantatore Francesco Paolo
Published: March 2021

Besides its well-known role as energy storage tissue, adipose tissue is a biologically active tissue that can also be considered as an endocrine organ, as it is able to secrete adipokines. These bioactive factors, similar in structure to cytokines, are involved in several physiological and pathological conditions, such as glucose homeostasis, angiogenesis, blood pressure regulation, control of food intake, and also inflammation and bone homeostasis via endocrine, paracrine, and autocrine mechanisms. Given their pleiotropic functions, the role of adipokines has been evaluated in chronic rheumatic osteoarticular inflammatory diseases, particularly focusing on their effects on inflammatory and immune response and on bone alterations. Indeed, these diseases are characterized by different bone complications, such as local and systemic bone loss and new bone formation. The aim of this review is to summarize the role of adipokines in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis, and osteoporosis, especially considering their role in the pathogenesis of bone complications typical of these conditions.
The linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target?
Authors: Gallardo Felipe S. , Córdova-Casanova Adriana , Brandan Enrique
Published: March 2021

Muscular dystrophies (MDs) are a diverse group of severe disorders characterized by increased skeletal muscle feebleness. In many cases, respiratory and cardiac muscles are also compromised. Skeletal muscle inflammation and fibrosis are hallmarks of several skeletal muscle diseases, including MDs. Until now, several keys signaling pathways and factors that regulate inflammation and fibrosis have been identified. However, no curative treatments are available. Therefore, it is necessary to find new therapeutic targets to fight these diseases and improve muscle performance. Lysophosphatidic acid (LPA) is an active glycerophospholipid mainly synthesized by the secreted enzyme autotaxin (ATX), which activates six different G protein-coupled receptors named LPA1 to LPA6 (LPARs). In conjunction, they are part of the ATX/LPA/LPARs axis, involved in the inflammatory and fibrotic response in several organs-tissues. This review recapitulates the most relevant aspects of inflammation and fibrosis in MDs. It analyzes experimental evidence of the effects of the ATX/LPA/LPARs axis on inflammatory and fibrotic responses. Finally, we speculate about its potential role as a new therapeutic pharmacological target to treat these diseases.
Platform Patterns—Using Proven Principles to Develop Digital Platforms
Authors: Drewel Marvin , Özcan Leon , Gausemeier Jürgen , Dumitrescu Roman
Published: March 2021

Hardly any other area has as much disruptive potential as digital platforms in the course of digitalization. After serious changes have already taken place in the B2C sector with platforms such as Amazon and Airbnb, the B2B sector is on the threshold to the so-called platform economy. In mechanical engineering, pioneers like GE (PREDIX) and Claas (365FarmNet) are trying to get their hands on the act. This is hardly a promising option for small and medium-sized companies, as only a few large companies will survive. Small and medium-sized enterprises (SMEs) are already facing the threat of losing direct consumer contact and becoming exchangeable executers. In order to prevent this, it is important to anticipate at an early stage which strategic options exist for the future platform economy and which adjustments to the product program should already be initiated today. Basically, medium-sized companies in particular lack a strategy for an advantageous entry into the future platform economy.

The paper presents different approaches to master the challenges of participating in the platform economy by using platform patterns. Platform patterns represent proven principles of already existing platforms. We show how we derived a catalogue with 37 identified platform patterns. The catalogue has a generic design and can be customized for a specific use case. The versatility of the catalogue is underlined by three possible applications: (1) platform ideation, (2) platform development, and (3) platform characterization.
Sex and Menstrual Phase Influences on Sleep and Memory
Authors: Alonso Alejandra , Genzel Lisa , Gomez Angela
Published: March 2021

Purposes of Review

This review highlights the effect of sex differences in sleep mediated memory consolidation and cognitive performance. In addition, the role of menstrual cycle and the fluctuating level of sexual hormones (mainly oestrogen and progesterone) are stressed.

Recent Findings

The literature indicates that sex hormones mediate and orchestrate the differences observed in performance of females in comparison with males in a variety of tasks and can also be related to how sleep benefits cognition. Although the exact mechanism of such influence is not clear, it most likely involves differential activation of brain areas, sensitivity to neuromodulators (mainly oestrogen), circadian regulation of sleep and temperature, as well as modification of strategies to solve tasks across the menstrual cycle.

With the evidence presented here, we hope to encourage researchers to develop appropriate paradigms to study the complex relationship between menstrual cycle, sleep (its regulation, architecture and electrophysiological hallmarks) and performance in memory and other cognitive tasks.
Kognitiv-motivationale Schüler*innenprofile und ihre Bedeutung für die Schüler*innenwahrnehmung der Lernunterstützung durch die Lehrperson
Authors: Ruelmann Merle , Torchetti Loredana , Zulliger Sandra , Buholzer Alois , Praetorius Anna-Katharina
Published: March 2021

Es ist eine zentrale Aufgabe von Lehrpersonen, Lernende während des Unterrichts individuell zu unterstützen. Im Hinblick auf die Nutzung von Unterstützungsangeboten spielt es eine entscheidende Rolle, wie diese Unterstützung von Schüler*innen wahrgenommen wird. Empirische Studien zeigen, dass die Wahrnehmung des Unterrichts interindividuell stark variiert. Die Ergebnisse deuten darauf hin, dass diese Variabilität auf unterschiedliche kognitive und affektiv-motivationale Voraussetzungen von Schüler*innen zurückgeführt werden kann. Bisher liegen jedoch kaum differenzielle Untersuchungen zur Schüler*innenwahrnehmung der Lernunterstützung vor, die systematisch Zusammenhänge mit individuellen Voraussetzungen in den Blick nehmen. An dieser Stelle setzt die vorliegende Studie mit dem Ziel an, mittels eines personenzentrierten Ansatzes zu einem besseren Verständnis unterschiedlicher Bedürfnisse hinsichtlich der Lernunterstützung beizutragen. Mittels latenter Profilanalysen wurden die Daten von 633 Mathematikschüler*innen der vierten Jahrgangsstufe ausgewertet. Auf diese Weise konnten vier verschiedene Schüler*innenprofile identifiziert werden: (1) starkes Profil, mit hoch ausgeprägter Selbstwirksamkeit, hoch ausgeprägter intrinsischer Motivation und hoch ausgeprägtem Vorwissen in Mathematik; (2) motiviertes Profil mit hoch ausgeprägter intrinsischer Motivation, durchschnittlicher Selbstwirksamkeit und geringem Vorwissen; (3) unmotiviertes Profil mit geringer Selbstwirksamkeit, geringer intrinsischer Motivation und mittlerem Vorwissen; (4) überfordertes Profil mit niedrigen Werten aller Variablen. Lernende mit starken oder motivierten Profilen nahmen die Lernunterstützung ihrer Lehrperson positiver wahr als Schüler*innen mit überforderten und unmotivierten Profilen. Diese Ergebnisse zeigen deutliche Unterschiede in der individuellen Wahrnehmung von Lernunterstützung und weisen diesbezüglich auf weiteren Forschungsbedarf hin.
Assessment of the Preparedness and Planning of Academic Emergency Departments in India During the COVID-19 Pandemic: A Multicentric Survey
Authors: Gopinathan Vivek , Kunju Sanjan Asanaru , Krishnan S Vimal , Sirur Freston Marc , Balakrishnan Jayaraj Mymbilly
Published: March 2021

Objective:

Emergency medicine being a young specialty in India, we aimed to assess the level of disaster preparedness and planning strategies among various academic emergency departments (EDs) across India during the coronavirus disease 2019 (COVID-19) pandemic.

Methods:

A cross-sectional multicentric survey was developed and disseminated online to various academic EDs in India and followed up over a period of 8 wk. All results were analyzed using descriptive statistics.

Results:

Twenty-eight academic emergency medicine departments responded to the study. Compared with pre-COVID period, COVID-19 pandemic has led to 90% of centers developing separate triage system with dedicated care areas for COVID suspected/infected in 78.6% centers with nearly 70% using separate transportation pathways. Strategizing and executing the Institutional COVID-19 treatment protocol in 80% institutes were done by emergency physicians. Training exercises for airway management and personal protective equipment (PPE) use were seen in 93% and 80% centers, respectively. Marked variation in recommended PPE use was observed across EDs in India.

Conclusions:

Our study highlights the high variance in the level of preparedness response among various EDs across India during the pandemic. Preparedness for different EDs across India needs to be individually assessed and planned according to the needs and resources available.
The Cuntz semigroup and the radius of comparison of the crossed product by a finite group
Authors: ASADI-VASFI M. ALI , GOLESTANI NASSER , PHILLIPS N. CHRISTOPHER
Published: March 2021

LetGbe a finite group, letAbe an infinite-dimensional stably finite simple unital C*-algebra, and let$\alpha \colon G \to {\operatorname {Aut}} (A)$be an action ofGonAwhich has the weak tracial Rokhlin property. Let$A^{\alpha }$be the fixed point algebra. Then the radius of comparison satisfies${\operatorname {rc}} (A^{\alpha }) \leq {\operatorname {rc}} (A)$and${\operatorname {rc}} ( C^* (G, A, \alpha ) ) \leq ({1}/{{{\operatorname{card}}} (G))} \cdot {\operatorname {rc}} (A)$. The inclusion of$A^{\alpha }$inAinduces an isomorphism from the purely positive part of the Cuntz semigroup${\operatorname {Cu}} (A^{\alpha })$to the fixed points of the purely positive part of${\operatorname {Cu}} (A)$, and the purely positive part of${\operatorname {Cu}} ( C^* (G, A, \alpha ) )$is isomorphic to this semigroup. We construct an example in which$G \,{=}\, {\mathbb {Z}} / 2 {\mathbb {Z}}$,Ais a simple unital AH algebra,$\alpha $has the Rokhlin property,${\operatorname {rc}} (A)> 0$,${\operatorname {rc}} (A^{\alpha }) = {\operatorname {rc}} (A)$, and${\operatorname {rc}} ({C^* (G, A, \alpha)} ) = ({1}/{2}) {\operatorname {rc}} (A)$.
Rights, Redistribution, and the Rise of the “Litigation State”: The Case of Disability Discrimination Laws
Authors: Engstrom David Freeman , Hausman David K.
Published: March 2021

Critics have long maintained that the rights revolution and, by extension, the postwar turn to litigation as a regulatory tool, are the product of a cynical legislative choice. On this view, legislators choose rights and litigation over alternative regulatory approaches to shift costs from on-budget forms (for example, publicly funded social provisions, public enforcement actions by prosecutors or agencies) to off-budget forms (for example, rights-based statutory duties, enforced via private lawsuits). This “cost-shift” theory has never been subjected to sustained theoretical scrutiny or comprehensive empirical test. This article offers the first such analysis, examining a context where the cost-shift hypothesis is at its most plausible: disability discrimination laws, which shift costs away from social welfare programs by requiring that employers hire and “accommodate” workers with disabilities. Using a novel dataset of state-level disability discrimination laws enacted prior to the federal-level Americans with Disabilities Act (ADA) and a range of archival and other materials drawn from state-level legislative campaigns, we find only limited support for the view that cost shifting offered at least part of the motivation for these laws. Our findings offer a fresh perspective on long-standing debates about American disability law and politics, including judicial interpretation of the ADA and its state-level analogues and the relationship of disability rights activism to other rights-based political movements.
Paleobiology of a large mammal community from the late Pleistocene of Sonora, Mexico
Authors: Short Rachel A. , Emmert Laura G. , Famoso Nicholas A. , Martin Jeff M. , Mead Jim I. , Swift Sandy L. , Baez Arturo
Published: March 2021

A paleontological deposit near San Clemente de Térapa represents one of the very few Rancholabrean North American Land Mammal Age sites within Sonora, Mexico. During that time, grasslands were common, and the climate included cooler and drier summers and wetter winters than currently experienced in northern Mexico. Here, we demonstrate restructuring in the mammalian community associated with environmental change over the past 40,000 years at Térapa. The fossil community has a similar number of carnivores and herbivores whereas the modern community consists mostly of carnivores. There was also a 97% decrease in mean body size (from 289 kg to 9 kg) because of the loss of megafauna. We further provide an updated review of ungulates and carnivores, recognizing two distinct morphotypes ofEquus, includingE.scottiand a slighter species; as well asPlatygonus compressus;Camelops hesternus;Canis dirus; andLynx rufus;and the first regional records ofPalaeolama mirifica,Procyon lotor, andSmilodoncf.S.fatalis. The Térapa mammals presented here provide a more comprehensive understanding of the faunal community restructuring that occurred in northern Mexico from the late Pleistocene to present day, indicating further potential biodiversity loss with continued warming and drying of the region.
Coffee and tea consumption and the risk of glioma: a systematic review and dose–response meta-analysis
Authors: Pranata Raymond , Feraldho Andrea , Lim Michael Anthonius , Henrina Joshua , Vania Rachel , Golden Nyoman , July Julius
Published: March 2021

In this systematic review and dose–response meta-analysis, we aimed to assess whether coffee and tea consumption is related to the risk of glioma. We performed a systematic literature search using PubMed, Embase, Scopus and the EuropePMC from the inception of database up until 1 October 2020. Exposures in the present study were coffee and tea consumption, the main outcome was the incidence of glioma. The present study compares the association between the exposure of coffee and tea with the incidence of glioma, and the results are reported in relative risks (RR). There are 12 unique studies comprising of 1 960 731 participants with 2987 glioma cases. Higher coffee consumption was associated with a statistically non-significant trend towards lower risk of glioma (RR 0·77 (95 % CI 0·55, 1·03), P= 0·11; I2:75·27 %). Meta-regression showed that the association between coffee and glioma was reduced by smoking (P= 0·029). Higher tea consumption was associated with a lower risk of glioma (RR 0·84 (95 % CI 0·71, 0·98), P= 0·030; I2:16·42 %). Sensitivity analysis by removal of case–control studies showed that higher coffee consumption (RR 0·85 (95 % CI 0·72, 1·00), P= 0·046; I2:0 %) and higher tea consumption (RR 0·81 (95 % CI 0·70, 0·93), P= 0·004; I2:0 %, Pnon-linearity = 0·140) were associated with lower risk of glioma. Dose–response meta-analysis showed that every one cup of coffee per day decreases the risk of glioma by 3 % (RR 0·97 (95 % CI 0·94, 0·99), P= 0·016, Pnon-linearity = 0·054) and every one cup of tea per day decreases the risk of glioma by 3 % (RR 0·97 (95 % CI 0·94, 1·00), P= 0·048). This meta-analysis showed apparent association between coffee and tea intake and risk of glioma.