bluuebunny/crossref_metadata_2025 huggingface dataset:
Selection of the Optimal Timber Harvest Based on Optimizing Stand Spatial Structure of Broadleaf Mixed Forests
Authors: Sheng Qi , Dong Lingbo , Chen Ying , Liu Zhaogang
Published: October 2023

There is increasing interest in optimizing stand structure through forest management. The forest structure influences growth and maintains the structure, promoting sustainability. Structure-based forest management (SBFM), which is based on the spatial relationships between a reference tree and its four nearest neighbors, considers the best spatial structure for the stand and promotes the development towards a healthy and stable state by selectively thinning specific trees. This management method is a scientific approach for sustainable forest management, and appropriate harvesting is the core principle of uneven-aged forest management. However, the application of this approach in the management of uneven-aged mixed stands is a challenge because their dynamics are more difficult to elucidate than those of planted or pure stands. This study presented a stand spatial structure optimization model with a transition matrix growth model for selecting suitable timber harvest during uneven-aged mixed-forest management optimization. The model was developed using three neighborhood-based structural indices (species mingling, diametric differentiation, and horizontal spatial pattern) and diameter diversity indices. The approach was applied to four broadleaf stands in the Maoershan Forest Farm of the Heilongjiang Province. The results demonstrate that optimizing the stand spatial structure with a transition matrix growth model improved the objective function values (F-index) by 23.8%, 12.8%, 14.6%, and 28.3%, and the optimal removal of trees from the stands ranged from 24.3% to 25.5%. The stand structure in the next cycle (after 5 years) was closer to the uneven-mixed state. The main conclusion of this study is that optimizing the stand spatial structure with a transition matrix growth model can improve the speed and accuracy of tree selection for harvesting in unevenly mixed forests, thus helping regulate stable and diverse forest growth.
Characteristics of Oat and Buckwheat Malt Grains for Use in the Production of Fermented Foods
Authors: Salamon Agnieszka , Kowalska Hanna , Ignaczak Anna , Marzec Agata , Kowalska Jolanta , Szafrańska Anna
Published: October 2023

Malted gluten-free cereal grains and pseudo-cereals are interesting raw materials for producing fermented foods. The aim of the work was to assess selected technological quality characteristics and antioxidant properties of special malts in terms of use in the production of fermented foods. The research material consisted of malts made from oat, buckwheat, and brewing barley. Malting was performed on a microtechnical scale according to the standard scheme for brewing barley grain. The basic quality parameters of cereal grains obtained malts, and laboratory wort were assessed according to methods applicable in brewing. Atypical brewing malts were characterized by parameters such as malt extractability, protein solubilization, diastatic force, mash filtration time, and wort viscosity. The best results, comparable to barley malt, were obtained for naked oat malt. Malted buckwheat grains turned out to be the least biochemically modified, although their use in the production of beer and/or other fermented beverages is supported by the high content of bioactive substances and antioxidant potential. As the malting process of cereal plants improves their antioxidant properties and increases their nutritional value, oat and buckwheat malts can be successfully used to produce gluten-free fermented beverages or as an addition to fermented products, e.g., in baking and confectionery.
Characterisation of Cooked Cheese Flavour: Non-Volatile Components
Authors: Sullivan Rosa C. , Nottage Samantha , Makinwa Fiyinfolu , Oruna-Concha Maria Jose , Fagan Colette C. , Parker Jane K.
Published: October 2023

This work examined the role of selected non-volatile compounds in cooked cheese flavour, both as tastants and as precursors of aroma generation in the Maillard reaction. The effect of cooking on the concentration of selected non-volatile compounds (organic acids, sugars, amino acids, γ-glutamyl dipeptides, and diketopiperazines) in six cheeses (mature Cheddar, mozzarella, Parmesan, and mild Cheddar (low, medium, and high fat)) was determined. Sugars, amino acids, and γ-glutamyl dipeptides were extracted and analysed by LC, whereas diketopiperazines were extracted by solid-phase extraction and analysed by GC-MS. Sugars, amino acids, and γ-glutamyl dipeptides decreased in concentration during cooking, whereas diketopiperazines and some organic acids increased in concentration. Diketopiperazines were above the taste threshold in some cooked cheeses and below the threshold in uncooked cheeses. The role of fat content in cooked cheese flavour is discussed. Furthermore, γ-glutamyl dipeptide concentration increased during 24 months of ageing in low, medium, and high-fat Cheddars, with similar levels of γ-glutamyl dipeptide detected in aged low and high-fat Cheddars. This work will give valuable insight for the dairy industry to inform the development of cheeses, especially low-fat variants, for use in cooked foods.
Effect of Supplementation with Curcuma longa and Rosmarinus officinalis Extract Mixture on Acute Phase Protein, Cathelicidin, Defensin and Cytolytic Protein Gene Expression in the Livers of Young Castrated Polish White Improved Bucks
Authors: Urbańska Daria M. , Pawlik Marek , Korwin-Kossakowska Agnieszka , Czopowicz Michał , Rutkowska Karolina , Kawecka-Grochocka Ewelina , Mickiewicz Marcin , Kaba Jarosław , Bagnicka Emilia
Published: October 2023

Goats are an excellent animal model for research on some physiological and pathophysiological processes in humans. The search for supplements that prevent homeostasis disorders and strengthen the immune system is necessary to reduce the risk of many diseases in both humans and animals. The aim of the study was to analyze the effect of supplementation with a mixture of dried extracts of Curcuma longa and Rosmarinus officinalis on the expression of acute-phase protein (SAA, HP, CRP, LALBA, AGP, CP, FGA, FGB, and FGG), cathelicidin (BAC5, BAC7.5, BAC3.4, MAP28, MAP34, and HEPC), beta-defensin-1 (GBD1, DEFB1), and beta-defensin-2, and cytolytic protein (LIZ and LF) genes in the livers of young castrated bucks of the Polish White Improved breed. The higher expression of LF in the control group suggests that it is important for the first line of hepatic immune defense and its expression is downregulated by the mixture of turmeric and rosemary extracts; thus, the spice–herb mixture mutes its activity. The lower expression of FGB and the higher expression of BAC5 genes in the livers of healthy, young castrated bucks who were administered the supplement suggest the silencing effects of the mixture on the acute-phase response and the stimulating effect on the antimicrobial activity of the immune system.
Deformation of High Rise Cooling Tower through Projection of Coordinates Resulted from Terrestrial Laser Scanner Observations onto a Vertical Plane
Authors: Beshr Ashraf A. A. , Basha Ali M. , El-Madany Samir A. , El-Azeem Fathi Abd
Published: October 2023

The appearance and development of new construction materials, technology and accurate geodetic instruments have led to the necessity of their inevitable use in the health monitoring, maintenance, and restoration of civil structures and special structures such as high-rise cooling towers. This paper presents an accurate practical and analytical method for determining the structural deformation and axis inclination of high rise cooling towers using terrestrial laser scanner (TLS) observations through the projection of tower surface points coordinates on a vertical plane. Four cooling towers in El-Mahla El-Kubra city, Egypt are observed and studied. Two of them with height 56 m, and the others were 36 m height. The studied four towers have different cross-section diameters along the tower height. Each tower has a cone shape with a curved wall. The equation of the tower wall is determined using TLS observations and least squares adjustment techniques. The equations of cone projection with a curved wall are derived and presented in this paper. From TLS observations, the radii and accuracy of each 2 m tower height are determined with center coordinates, and then the inclination of the tower axis is calculated and drawn. From the results of TLS observations, data processing, and analysis using the suggested techniques, it is deduced that there is a deformation in tower walls with small values. The specified technique for observations collection and TLS data analysis through projection on a vertical plane is significant and valuable for determining the structural deformation of circular high rise buildings and towers. From the results, there are obvious deformation values in some cooling towers, so maintenance work must be included. The towers also must be checked and monitored several times at brief intervals.
Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential
Authors: Clerici Marta , Citro Vera , Byrne Amy L. , Dale Tina P. , Boccaccini Aldo R. , Della Porta Giovanna , Maffulli Nicola , Forsyth Nicholas R.
Published: October 2023

Tendon injuries caused by overuse or age-related deterioration are frequent. Incomplete knowledge of somatic tendon cell biology and their progenitors has hindered interventions for the effective repair of injured tendons. Here, we sought to compare and contrast distinct tendon-derived cell populations: type I and II tendon stem cells (TSCs) and tenocytes (TNCs). Porcine type I and II TSCs were isolated via the enzymatic digestion of distinct membranes (paratenon and endotenon, respectively), while tenocytes were isolated through an explant method. Resultant cell populations were characterized by morphology, differentiation, molecular, flow cytometry, and immunofluorescence analysis. Cells were isolated, cultured, and evaluated in two alternate oxygen concentrations (physiological (2%) and air (21%)) to determine the role of oxygen in cell biology determination within this relatively avascular tissue. The different cell populations demonstrated distinct proliferative potential, morphology, and transcript levels (both for tenogenic and stem cell markers). In contrast, all tendon-derived cell populations displayed multipotent differentiation potential and immunophenotypes (positive for CD90 and CD44). Type II TSCs emerged as the most promising tendon-derived cell population for expansion, given their enhanced proliferative potential, multipotency, and maintenance of a tenogenic profile at early and late passage. Moreover, in all cases, physoxia promoted the enhanced proliferation and maintenance of a tenogenic profile. These observations help shed light on the biological mechanisms of tendon cells, with the potential to aid in the development of novel therapeutic approaches for tendon disorders.
Is the Neuropeptide PEN a Ligand of GPR83?
Authors: Giesecke Yvonne , Asimi Vahid , Stulberg Valentina , Kleinau Gunnar , Scheerer Patrick , Koksch Beate , Grötzinger Carsten
Published: October 2023

G protein-coupled receptor 83 (GPR83) is a class A G protein-coupled receptor with predominant expression in the cerebellum and proposed function in the regulation of food intake and in anxiety-like behavior. The neuropeptide PEN has been suggested as a specific GPR83 ligand. However, conflicting reports exist about whether PEN is indeed able to bind and activate GPR83. This study was initiated to evaluate PEN as a potential ligand of GPR83. Employing several second messenger and other GPCR activation assays as well as a radioligand binding assay, and using multiple GPR83 plasmids and PEN peptides from different sources, no experimental evidence was found to support a role of PEN as a GPR83 ligand.
Transfer Learning-Based YOLOv3 Model for Road Dense Object Detection
Authors: Zhu Chunhua , Liang Jiarui , Zhou Fei
Published: October 2023

Stemming from the overlap of objects and undertraining due to few samples, road dense object detection is confronted with poor object identification performance and the inability to recognize edge objects. Based on this, one transfer learning-based YOLOv3 approach for identifying dense objects on the road has been proposed. Firstly, the Darknet-53 network structure is adopted to obtain a pre-trained YOLOv3 model. Then, the transfer training is introduced as the output layer for the special dataset of 2000 images containing vehicles. In the proposed model, one random function is adapted to initialize and optimize the weights of the transfer training model, which is separately designed from the pre-trained YOLOv3. The object detection classifier replaces the fully connected layer, which further improves the detection effect. The reduced size of the network model can further reduce the training and detection time. As a result, it can be better applied to actual scenarios. The experimental results demonstrate that the object detection accuracy of the presented approach is 87.75% for the Pascal VOC 2007 dataset, which is superior to the traditional YOLOv3 and the YOLOv5 by 4% and 0.59%, respectively. Additionally, the test was carried out using UA-DETRAC, a public road vehicle detection dataset. The object detection accuracy of the presented approach reaches 79.23% in detecting images, which is 4.13% better than the traditional YOLOv3, and compared with the existing relatively new object detection algorithm YOLOv5, the detection accuracy is 1.36% better. Moreover, the detection speed of the proposed YOLOv3 method reaches 31.2 Fps/s in detecting images, which is 7.6 Fps/s faster than the traditional YOLOv3, and compared with the existing new object detection algorithm YOLOv7, the speed is 1.5 Fps/s faster. The proposed YOLOv3 performs 67.36 Bn of floating point operations per second in detecting video, which is obviously less than the traditional YOLOv3 and the newer object detection algorithm YOLOv5.
The Role of Neurophysiology in Managing Patients with Chiari Malformations
Authors: Moncho Dulce , Poca Maria A. , Rahnama Kimia , Sánchez Roldán M. Ángeles , Santa-Cruz Daniela , Sahuquillo Juan
Published: October 2023

Chiari malformation type 1 (CM1) includes various congenital anomalies that share ectopia of the cerebellar tonsils lower than the foramen magnum, in some cases associated with syringomyelia or hydrocephalus. CM1 can cause dysfunction of the brainstem, spinal cord, and cranial nerves. This functional alteration of the nervous system can be detected by various modalities of neurophysiological tests, such as brainstem auditory evoked potentials, somatosensory evoked potentials, motor evoked potentials, electromyography and nerve conduction studies of the cranial nerves and spinal roots, as well as brainstem reflexes. The main goal of this study is to review the findings of multimodal neurophysiological examinations in published studies of patients with CM1 and their indication in the diagnosis, treatment, and follow-up of these patients, as well as their utility in intraoperative monitoring.
Point-of-Care Ultrasound in Detection, Severity and Mechanism of Significant Valvular Heart Disease and Clinical Management
Authors: Wen Songnan , Naqvi Tasneem Z.
Published: October 2023

Background: Early diagnosis of significant valvular heart disease (VHD) enables appropriate implementation of the best therapeutic strategy and follow-up. Cardiac auscultation remains suboptimal in early detection of VHD. The aim of this study was to evaluate the utility of point-of-care ultrasound (POCUS) for early detection of VHD and its severity. Methods: All consecutive patients with VHD who did not have a standard echocardiogram prior to first outpatient cardiology consultation underwent history and physical examination followed by POCUS study by an experienced physician in a general cardiology clinic from June 2017 to August 2022 at our institution. Subsequent standard transthoracic echocardiography (sTTE) was performed as the gold standard. Comparison was performed between POCUS and sTTE for the presence and severity of VHD. sTTE was performed by registered cardiac sonographers and interpreted by another cardiologist blinded to the POCUS results. Results: A total of 77 patients were studied (ge 72 ± 11 years, 58.4% males). A total of 89 significant valvular abnormalities were diagnosed. There were 39 (43.8%) cases of regurgitant VHD, 16 (18.0%) of stenotic VHD and 34 (38.2%) had evaluation for prosthetic valve function. The sensitivity (90.9%; 82.4%; 83.3%; 100%) and specificity (100%; 96.7%; 100%; 100%) were high for detecting ≥ moderate aortic regurgitation (AR), mitral regurgitation (MR), aortic stenosis (AS) and prosthetic valvular abnormality, respectively. The weighted κ coefficient between POCUS and sTTE for the assessment of ≥ moderate MR, AR and AS was 0.81 (95% CI, 0.65–0.97), 0.94 (95% CI, 0.84–1.00) and 0.88 (95% CI, 0.76–1.0), respectively, indicating excellent agreement. Conclusions: POCUS can identify patients with significant VHD and may serve as a powerful screening tool for early detection of significant VHD in the outpatient clinical practice with downstream impact on clinical management of significant VHD.
Safety and Efficacy of Three Modifications of Canaloplasty to Treat Open-Angle Glaucoma: 3-Year Outcomes
Authors: Kicińska Aleksandra K. , Rękas Marek
Published: October 2023

Background: This is a report of 3-year results of a prospective assessment of three modifications of canaloplasty (C): ab externo (ABeC), mini-canaloplasty (miniABeC), and ab interno (ABiC) performed concomitantly with cataract removal in subjects suffering from primary open-angle glaucoma (POAG). Methods: Forty-eight individuals were randomized for one of the surgeries: ABeC, miniABeC, or ABiC and cataract removal—16 eyes for each group. Follow-up examinations were carried out on the day of the surgery, on days 1 and 7, after 1, 3, 6 months, and at 1, 2, and 3 years. Complete and qualified success was an IOP ≤ 15 mmHg without or with antiglaucoma eye drops, respectively. The IOP reduction of 20% or more was considered an additional success criterion. Results: Within three years the probability of qualified success was ABiC and miniABeC—94%, ABeC—100%, and of complete success ABiC—75%, miniABeC—100%. At the 3-year follow-up, the median IOP decreased from 22 to 15 mmHg in the ABeC group (p = 0.001), from 22 to 15 mmHg in the miniABeC group 15 (p < 0.001), and from 21 to 15 mmHg in the ABiC group (p = 0.001) compared to the post-washout stage. The IOP dropped by 20% or more without medications in 56.2% of patients post ABiC, 68.8% post miniABeC and 75% post ABeC. The median number of antiglaucoma medications dropped in all three groups; at the 3-year follow-up, only one patient following ABeC and four subjects following miniABeC required treatment. One patient required reoperation and further intensification of topical treatment—post miniABeC. The levels of IOP, CDVA, and success probability at the 36-month follow-up showed no significant difference for individual groups. Conclusions: ABeC, miniABeC, and ABiC have significant IOP-lowering potential in individuals diagnosed with POAG at a mild to moderate stage and no history of IOP ≥ 30 mmHg with a good safety profile.
Herpes Zoster Oticus with Concurrent Hearing Loss: A Study on Clinical Characteristics and Prognosis
Authors: Rim Hwa Sung , Chung Seok Hwan , Kim Ho Joong , Yeo Seung Geun , Kim Sang Hoon
Published: October 2023

This study aimed to analyze the clinical characteristics and treatment prognoses of patients with Herpes Zoster Oticus (HZO) and concurrent hearing loss (HL). Various clinical characteristics of 192 patients with HZO, with or without concurrent HL, from 2016 to 2020 were retrospectively analyzed through a chart review. All patients were followed-up until recovery or up to 12 months. Demographic and clinical findings were compared between the groups, and the recovery rates of facial palsy, hearing, and other clinical features were analyzed. Facial palsy recovery was analyzed using the House–Brackmann (HB) grading system, and hearing recovery rates were analyzed using the Siegel criteria. Of the 192 patients diagnosed with HZO, 142 had no hearing loss (HZO without HL), and 50 had hearing loss (HZO with HL). While both groups had similar ages, treatment timings, and underlying diseases, the HZO w HL group had a significantly higher rate of dizziness and tinnitus, but received more intratympanic steroid injections. In terms of facial palsy, there were no significant differences in the initial HB grade or recovery rates between the groups. Within the HZO w HL group, hearing loss severity varied, with 52% experiencing mild loss and only 16% achieving complete recovery. Descending-type audiograms were the most common at 66%. In patients with HZO, there was no statistically significant difference between the degree of initial facial paralysis and the degree of recovery of the final facial paralysis according to concurrent HL. However, among patients with concurrent HL, the hearing recovery rate in the HZO group was low.
The FCGR2A Is Associated with the Presence of Atherosclerotic Plaques in the Carotid Arteries—A Case-Control Study
Authors: Szpakowicz Anna , Szum-Jakubowska Aleksandra , Lisowska Anna , Dubatówka Marlena , Raczkowski Andrzej , Czajkowski Marcin , Szczerbiński Łukasz , Chlabicz Małgorzata , Krętowski Adam , Kamiński Karol Adam
Published: October 2023

Background. Atherosclerotic plaques in carotid arteries (APCA) are a prevalent condition with severe potential complications. Studies continuously search for innovative biomarkers for APCA, including those participating in cellular metabolic processes, cell adhesion, immune response, and complement activation. This study aimed to assess the relationship between APCA presence and a broad range of cardiometabolic biomarkers in the general population. Methods. The study group consisted of consecutive participants of the population study Bialystok PLUS. The proximity extension assay (PEA) technique from the Olink Laboratory (Uppsala, Sweden) was used to measure the levels of 92 cardiometabolic biomarkers. Results. The study comprised 693 participants (mean age 48.78 ± 15.27 years, 43.4% males, N = 301). APCA was identified in 46.2% of the participants (N = 320). Of the 92 biomarkers that were investigated, 54 were found to be significantly linked to the diagnosis of APCA. After adjusting for the traditional risk factors for atherosclerosis in multivariate analysis, the only biomarker that remained significantly associated with APCA was FCGR2A. Conclusion. In the general population, the prevalence of APCA is very high. A range of biomarkers are linked with APCA. Nonetheless, the majority of these associations are explained by traditional risk factors for atherosclerosis. The only biomarker that was independently associated with APCA was the FCGR2A.
Classification and Quantification of Physical Therapy Interventions across Multiple Neurological Disorders: An Italian Multicenter Network
Authors: Bowman Thomas , Mestanza Mattos Fabiola Giovanna , Salvalaggio Silvia , Marazzini Francesca , Allera Longo Cristina , Bocini Serena , Gennuso Michele , Materazzi Francesco Giuseppe , Pelosin Elisa , Putzolu Martina , Russo Rita , Turolla Andrea , Mezzarobba Susanna , Cattaneo Davide
Published: October 2023

Despite their relevance in neurorehabilitation, physical therapy (PT) goals and interventions are poorly described, compromising a proper understanding of PT effectiveness in everyday clinical practice. Thus, this paper aims to describe the prevalence of PT goals and interventions in people with neurological disorders, along with the participants’ clinical features, setting characteristics of the clinical units involved, and PT impact on outcome measures. A multicenter longitudinal observational study involving hospitals and rehabilitation centers across Italy has been conducted. We recruited people with stroke (n = 119), multiple sclerosis (n = 48), and Parkinson’s disease (n = 35) who underwent the PT sessions foreseen by the National Healthcare System. Clinical outcomes were administered before and after the intervention, and for each participant the physical therapists completed a semi-structured interview to report the goals and interventions of the PT sessions. Results showed that the most relevant PT goals were related to the ICF activities with “walking” showing the highest prevalence. The most used interventions aimed at improving walking performance, followed by those aimed at improving organ/body system functioning, while interventions targeting the cognitive–affective and educational aspects have been poorly considered. Considering PT effectiveness, 83 participants experienced a clinically significant improvement in the outcome measures assessing gait and balance functions.
AI-Enhanced Analysis Reveals Impact of Maternal Diabetes on Subcutaneous Fat Mass in Fetuses without Growth Alterations
Authors: Borboa-Olivares Hector , Torres-Torres Johnatan , Flores-Pliego Arturo , Espejel-Nuñez Aurora , Camacho-Arroyo Ignacio , Guzman-Huerta Mario , Perichart-Perera Otilia , Piña-Ramirez Omar , Estrada-Gutierrez Guadalupe
Published: October 2023

Pregnant women with diabetes often present impaired fetal growth, which is less common if maternal diabetes is well-controlled. However, developing strategies to estimate fetal body composition beyond fetal growth that could better predict metabolic complications later in life is essential. This study aimed to evaluate subcutaneous fat tissue (femur and humerus) in fetuses with normal growth among pregnant women with well-controlled diabetes using a reproducible 3D-ultrasound tool and offline TUI (Tomographic Ultrasound Imaging) analysis. Additionally, three artificial intelligence classifier models were trained and validated to assess the clinical utility of the fetal subcutaneous fat measurement. A significantly larger subcutaneous fat area was found in three-femur and two-humerus selected segments of fetuses from women with diabetes compared to the healthy pregnant control group. The full classifier model that includes subcutaneous fat measure, gestational age, fetal weight, fetal abdominal circumference, maternal body mass index, and fetal weight percentile as variables, showed the best performance, with a detection rate of 70%, considering a false positive rate of 10%, and a positive predictive value of 82%. These findings provide valuable insights into the impact of maternal diabetes on fetal subcutaneous fat tissue as a variable independent of fetal growth.
The Sympathetic Nervous System in Hypertensive Heart Failure with Preserved LVEF
Authors: Triposkiadis Filippos , Briasoulis Alexandros , Sarafidis Pantelis , Magouliotis Dimitrios , Athanasiou Thanos , Paraskevaidis Ioannis , Skoularigis John , Xanthopoulos Andrew
Published: October 2023

The neurohormonal model of heart failure (HF) pathogenesis states that a reduction in cardiac output caused by cardiac injury results in sympathetic nervous system (SNS) activation, that is adaptive in the short-term and maladaptive in the long-term. This model has proved extremely valid and has been applied in HF with a reduced left ventricular (LV) ejection fraction (LVEF). In contrast, it has been undermined in HF with preserved LVEF (HFpEF), which is due to hypertension (HTN) in the vast majority of the cases. Erroneously, HTN, which is the leading cause of cardiovascular disease and premature death worldwide and is present in more than 90% of HF patients, is tightly linked with SNS overactivity. In this paper we provide a contemporary overview of the contribution of SNS overactivity to the development and progression of hypertensive HF (HHF) as well as the clinical implications resulting from therapeutic interventions modifying SNS activity. Throughout the manuscript the terms HHF with preserved LVEF and HfpEF will be used interchangeably, considering that the findings in most HFpEF studies are driven by HTN.
Distinct Food Triggers for Migraine, Medication Overuse Headache and Irritable Bowel Syndrome
Authors: Ceren Akgor Merve , Vuralli Doga , Sucu Damla Hazal , Gokce Saliha , Tasdelen Bahar , Gultekin Fatih , Bolay Hayrunnisa
Published: October 2023

Background: Irritable bowel syndrome (IBS) is an under-diagnosed common health problem that impairs quality of life. Migraine and IBS are comorbid disorders that are triggered by foods. We aim to investigate IBS frequency in medication overuse headache (MOH) patients and identify food triggers and food avoidance behavior. Methods: Participants who completed the cross-sectional, observational and online survey were included (n = 1118). Demographic data, comorbid disorders, medications used, presence of headache, the diagnostic features of headache and IBS, migraine related subjective cognitive symptoms scale (MigSCog), consumption behavior of patients regarding 125 food/food additives and food triggers were asked about in the questionnaire. Results: Migraine and MOH diagnoses were made in 88% and 30.7% of the participants, respectively. Non-steroidal anti-inflammatory drugs (NSAIDs) were the main overused drug (89%) in MOH patients. IBS symptoms were present in 35.8% of non-headache sufferers, 52% of migraine patients and 65% of MOH patients. Specific food triggers for MOH patients were dopaminergic and frequently consumed as healthy foods such as banana, apple, cherry, apricot, watermelon, olive, ice cream and yogurt. MigSCog scores were significantly higher in episodic migraine and MOH patients when IBS symptoms coexisted. Conclusions: The frequency of IBS was higher in MOH patients compared to migraine patients. Coexistence of IBS seems to be a confounding factor for cognitive functions. MOH specific triggers were mostly dopaminergic foods, whereas migraine specific food triggers were mostly histaminergic and processed foods. Personalized diets focusing on food triggers and interference with leaky gut must be integrated to MOH and migraine treatment to achieve sustainable management of these disorders.
Mechanisms and Prediction of Ischemic Stroke in Atrial Fibrillation Patients
Authors: Aarnink Errol , Zabern Maxime , Boersma Lucas , Glikson Michael
Published: October 2023

Atrial fibrillation (AF) is the most common arrhythmia in adults worldwide and represents an important burden for patients, physicians, and healthcare systems. AF is associated with substantial mortality and morbidity, due to the disease itself and its specific complications, such as the increased risk of stroke and thromboembolic events associated with AF. The temporal relation between AF episodes and stroke is nonetheless incompletely understood. The factors associated with an increased thromboembolic risk remain unclear, as well as the stroke risk stratification. Therefore, in this review, we intend to expose the mechanisms and physiopathology leading to intracardiac thrombus formation and stroke in AF patients, together with the evidence supporting the causal hypothesis. We also expose the risk factors associated with increased risk of stroke, the current different risk stratification tools as well as future prospects for improving this risk stratification.
The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease
Authors: Walmer Rachel W. , Ritter Victor S. , Sridharan Anush , Kasoji Sandeep K. , Altun Ersan , Lee Ellie , Olinger Kristen , Wagner Sean , Radhakrishna Roshni , Johnson Kennita A. , Rathmell W. Kimryn , Qaqish Bahjat , Dayton Paul A. , Chang Emily H.
Published: October 2023

We investigated the accuracy of CEUS for characterizing cystic and solid kidney lesions in patients with chronic kidney disease (CKD). Cystic lesions are assessed using Bosniak criteria for computed tomography (CT) and magnetic resonance imaging (MRI); however, in patients with moderate to severe kidney disease, CT and MRI contrast agents may be contraindicated. Contrast-enhanced ultrasound (CEUS) is a safe alternative for characterizing these lesions, but data on its performance among CKD patients are limited. We performed flash replenishment CEUS in 60 CKD patients (73 lesions). Final analysis included 53 patients (63 lesions). Four readers, blinded to true diagnosis, interpreted each lesion. Reader evaluations were compared to true lesion classifications. Performance metrics were calculated to assess malignant and benign diagnoses. Reader agreement was evaluated using Bowker’s symmetry test. Combined reader sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for diagnosing malignant lesions were 71%, 75%, 45%, and 90%, respectively. Sensitivity (81%) and specificity (83%) were highest in CKD IV/V patients when grouped by CKD stage. Combined reader sensitivity, specificity, PPV, and NPV for diagnosing benign lesions were 70%, 86%, 91%, and 61%, respectively. Again, in CKD IV/V patients, sensitivity (81%), specificity (95%), and PPV (98%) were highest. Inter-reader diagnostic agreement varied from 72% to 90%. In CKD patients, CEUS is a potential low-risk option for screening kidney lesions. CEUS may be particularly beneficial for CKD IV/V patients, where kidney preservation techniques are highly relevant.
The Relationship between Oral Health and Schizophrenia in Advanced Age—A Narrative Review in the Context of the Current Literature
Authors: Santhosh Kumar Sanjana , Cantillo Raquel , Ye Dongxia
Published: October 2023

Schizophrenia is a psychiatric disorder that makes patients incompetent to perform day-to-day activities due to their progressing mental illness. In addition to disturbances with thoughts, behavioral changes, and impaired cognitive functions, oro-systemic health also becomes compromised. Even though the population with schizophrenia is primarily made up of older people, little is known about this group’s oral health treatment. The present review explores the relationship between oral healthcare and elderly patients with schizophrenia. Our literature search included databases, like PubMed, Embase, and Google Scholar, for appropriate and evidence-based information. Preventive and management strategies outlined in the included articles and future research perspectives in this field are discussed. To the best of our knowledge, this is the first review that looked at dental care and related characteristics in older schizophrenia patients. The findings highlight the necessity for targeted dental interventions to address the dental health challenges faced by this vulnerable population. Integrating dental health into the overall medical management of elderly individuals with schizophrenia is crucial. Although specific therapies remain limited, the emphasis is on preventive dentistry to reduce the occurrence and progression of oral diseases in this group.
Bradyphrenia and Tachyphrenia in Idiopathic Parkinsonism Appear, in Part, Iatrogenic: An Observational Study with Systematic Review Background
Authors: Wang Wenjing , Baker Kieran , Umamahesan Chianna , Gilmour Steven , Charlett André , Taylor David , Young Allan H. , Dobbs R. John , Dobbs Sylvia M.
Published: October 2023

We question whether bradyphrenia, slowing of cognitive processing not explained by depression or a global cognitive assessment, is a nosological entity in idiopathic parkinsonism (IP). The time taken to break contact of an index finger with a touch-sensitive plate was measured, with and without a warning in the alerting signal as to which side the imperative would indicate, in 77 people diagnosed with IP and in 124 people without an IP diagnosis. The ability to utilise a warning, measured by the difference between loge-transformed reaction times (unwarned minus warned), was termed ‘cognitive efficiency’. It was approximately normally distributed. A questionnaire on self- and partner perception of proband’s bradyphrenia was applied. A multivariable model showed that those prescribed levodopa were less cognitively efficient (mean −5.2 (CI −9.5, −1.0)% per 300 mg/day, p = 0.02), but those prescribed the anti-muscarinic trihexyphenidyl were more efficient (14.7 (0.2, 31.3)% per 4 mg/day, p < 0.05) and those prescribed monoamine oxidase-B inhibitor (MAOBI) tended to be more efficient (8.3 (0.0, 17.4)%, p = 0.07). The variance in efficiency was greater within IP (F-test, p = 0.01 adjusted for any demographic covariates: coefficient of variation, with and without IP, 0.68 and 0.46, respectively), but not so after adjustment for anti-parkinsonian medication (p = 0.13: coefficient of variation 0.62). The within-participant follow-up time, a median of 4.8 (interquartile range 3.1, 5.5) years (101 participants), did not influence efficiency, irrespective of IP status. Perception of bradyphrenia did not usefully predict efficiency. We conclude that both bradyphrenia and ‘tachyphrenia’ in IP appear to have iatrogenic components, of clinically important size, related to the dose of antiparkinsonian medication. Levodopa is the most commonly prescribed first-line medication: co-prescribing a MAOBI may circumvent its associated bradyphrenia. The previously reported greater efficiency associated with (low-dose) anti-muscarinic was confirmed.
Minimal Clinically Important Differences in Gait and Balance Ability in Patients Who Underwent Corrective Long Spinal Fusion for Adult Spinal Deformity
Authors: Sakaguchi Tomoyoshi , Meena Umesh , Tanaka Masato , Xiang Hongfei , Fujiwara Yoshihiro , Arataki Shinya , Taoka Takuya , Takamatsu Kazuhiko , Yasuda Yosuke , Nakagawa Masami , Utsunomiya Kayo
Published: October 2023

Study Design: Retrospective observational study. Background: The risk of a femoral neck fracture due to a fall after adult spinal deformity surgery has been reported. One of the most significant factors among walking and balance tests in post-operative ASD patients was the timed up-and-go test (TUG). This study aims to calculate the minimal clinically important difference (MCID) in balance tests after ASD surgery. Methods: Forty-eight patients, 4 males and 44 females, were included by exclusion criteria in 66 consecutive patients who underwent corrective surgery as a treatment for ASD at our institution from June 2017 to February 2022. The inclusion criteria for this study were age ≥50 years; and no history of high-energy trauma. The exclusion criteria were dementia, severe deformity of the lower extremities, severe knee or hip osteoarthritis, history of central nervous system disorders, cancer, and motor severe paralysis leading to gait disorders. The surgeries were performed in two stages, first, the oblique lumber interbody fusion (OLIF) L1 to L5 (or S1), and second, the posterior corrective fusion basically from T10 to pelvis. For outcome assessment, 10 m walk velocity, TUG, ODI, and spinopelvic parameters were used. Results: Ten meter walk velocity of pre-operation and post-operation were 1.0 ± 0.3 m/s and 1.2 ± 0.2 m/s, respectively (p < 0.01). The TUG of pre-operation and post-operation were 12.1 ± 3.7 s and 9.7 ± 2.2 s, respectively (p < 0.01). The ODI improved from 38.6 ± 12.8% to 24.2 ± 15.9% after surgery (p < 0.01). All post-operative parameters except PI obtained statistically significant improvement after surgery. Conclusions: This is the first report of MCID of the 10 m walk velocity and TUG after ASD surgery. Ten meter walk velocity and the TUG improved after surgery; their improvement values were correlated with the ODI. MCID using the anchor-based approach for 10 m walk velocity and the TUG were 0.10 m/s and 2.0 s, respectively. These MCID values may be useful for rehabilitation after ASD surgery.
Flow Field Pattern and Hydrodynamic Characteristics of a Grid Device Made with Various Grid Bar Spacings at Different Inclination Angles
Authors: Zhang Can , Tang Hao , Thierry Nyatchouba Nsangue Bruno , Yin Liqiang , Zhang Feng , Zhu Meixi , Shan Chenxu , Xu Liuxiong , Hu Fuxiang
Published: October 2023

The grid is a crucial component in constructing grid-type bycatch reduction devices. The grid’s structural characteristics and orientation significantly impact the hydrodynamic characteristics and efficacy of the separation device. Therefore, it is essential to thoroughly understand the grid device’s hydrodynamic characteristics and flow field to optimize its structure. Thus, this study used CFD numerical simulation and flume tank experiments to investigate the effects of inclination grid angles and grid bar spacing on hydrodynamic forces and flow fields around a circular grid. The results indicated that the hydrodynamic forces acting on the circular grid increased with higher flow velocity and inclination grid angle, decreasing with smaller grid bar spacing. Flow velocity acceleration zones were observed at the upper and lower ends of the grid and between the grid bars. Additionally, upwelling and vortices were present at the back of the grid. It was found that an increase in the inclination grid angle accelerated the vortex and wake effects.
Results of the Study of Resonant Oscillations in the Northern Part of the Shelf of the Peter the Great Gulf, the Sea of Japan
Authors: Smirnov Sergey , Dolgikh Grigory , Yaroshchuk Igor , Lazaryuk Alexander , Kosheleva Alexandra , Shvyrev Alex , Pivovarov Alexander , Samchenko Aleksandr
Published: October 2023

To study the features of resonant oscillations in the water column of the Peter the Great Gulf of the Sea of Japan, in situ measurements were carried out on its shelf, combined with numerical simulation of these processes. The observational data were obtained from autonomous bottom pressure gauges in Novik Bay in the winter of 2016. In the calculations, a spectral-difference model was used, modified to account for the ice cover, and implemented on an irregular triangular grid. The atmospheric forcing used in the model had periods from 15 to 55 min. As a result, characteristic series of spatio-temporal parameters for resonant oscillations of the studied water area were determined. The locations of the peaks on the simulated resonance curves correspond to the locations of well-defined maxima of the energy spectrum according to in situ measurements, hence indicating the possibility of a significant resonant amplification of level fluctuations by wave and periodic wind effects. The novelty of this study is inclusion of the winter period, when the surface of the bay is partially covered with ice.
Theoretical Analysis of Plastic Behavior of Sandwich Beam with Metal Foam under Repeated Impacts
Authors: Guo Kailing , Mu Mengying , Cai Wei , Xu Bofang , Zhu Ling
Published: October 2023

The phenomenon of repeated impacts on engineering structures is very common, especially in naval and ocean engineering. When marine structures are subjected to repeated impact loadings, deformation and damage will accumulate as the impact number increases, resulting in the failure and damage of the structures, even causing serious accidents. Based on the rigid-plastic assumption, a theoretical model is established to analyze the plastic mechanical behavior of metal foam sandwich beams (MFSBs) suffering from repeated impacts, in which the membrane factor method (MFM) is applied to derive analytical solutions for the plastic responses of MFSBs. The theoretical predictions agree well with the results of impact tests and numerical simulations, indicating that the theoretical model is accurate and reliable. In addition, the dynamic responses of MFSBs are analyzed based on the MFM, and the effects of the core strength and the face thickness on the deflection responses are determined. The results show that the dimensionless permanent deflection of MFSBs is sensitive to the core strength ratio and the face thickness ratio, and as the core strength ratio or the face thickness ratio increases, the dimensionless permanent deflection decreases gradually in an exponential form. In addition, the influence of the core strength ratio and face thickness ratio becomes more significant as the impact number increases. The proposed theoretical method can provide a theoretical reference and technical support for the design of metal foam sandwich structures with improved impact resistance under repeated impact loadings.
Clinical, Microbiological and Treatment Characteristics of Severe Postoperative Respiratory Infections: An Observational Cohort Study
Authors: Benítez-Cano Adela , Bermejo Silvia , Luque Sonia , Sorlí Luisa , Carazo Jesús , Zaragoza Irene , Ramos Isabel , Vallès Jordi , Horcajada Juan P. , Adalia Ramón
Published: October 2023

Respiratory infections are frequent and life-threatening complications of surgery. This study aimed to evaluate the clinical, microbiological and treatment characteristics of severe postoperative pneumonia (POP) and tracheobronchitis (POT) in a large series of patients. This single-center, prospective observational cohort study included patients with POP or POT requiring intensive care unit admission in the past 10 years. We recorded demographic, clinical, microbiological and therapeutic data. A total of 207 patients were included, and 152 (73%) were men. The mean (SD) age was 70 (13) years and the mean (SD) ARISCAT score was 46 (19). Ventilator-associated pneumonia was reported in 21 patients (10%), hospital-acquired pneumonia was reported in 132 (64%) and tracheobronchitis was reported in 54 (26%). The mean (SD) number of days from surgery to POP/POT diagnosis was 6 (4). The mean (SD) SOFA score was 5 (3). Respiratory microbiological sampling was performed in 201 patients (97%). A total of 177 organisms were cultured in 130 (63%) patients, with a high proportion of Gram-negative and multi-drug resistant (MDR) bacteria (20%). The most common empirical antibiotic therapy was a triple-drug regimen covering MDR Gram-negative bacteria and MRSA. In conclusion, surgical patients are a high-risk population with a high proportion of early onset severe POP/POT and nosocomial bacteria isolation.
A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis
Authors: Sazzad Faizus , Ramanathan Kollengode , Moideen Irwan Shah , Gohary Abdulrahman El , Stevens John Carey , Kofidis Theo
Published: October 2023

Personalized surgery is not just a new trend but rather a patient-specific approach to therapy that makes it possible to adopt a targeted approach for a specific patient and closely mirrors the approach of personalized medicine. However, the application of tailored surgery in the context of cardiovascular replacement surgery has not been systematically reviewed. The ability to customize a device is highly dependent on the collection of radiological image data for precise prosthesis modeling. These facts are essential to “tailor-made” device design for precise prosthesis implantation. According to this study, computed tomography (CT) was the most prominent imaging modality; however, transesophageal echocardiography and echocardiography were also found to be helpful. Additionally, a dynamic finite element simulation was also found to be an attractive alternative to the finite element analysis for an in-silico experiment. Nonetheless, there is a paucity of relevant publications and only sporadic evidence. More clinical studies have been warranted, notwithstanding that the derived data and results from this insight into the use of therapeutic interventions may be evidence of multiple directives in clinical practices and beyond. This study may help the integration of personalized devices for better comprehension of predicted clinical outcomes, thus leading towards enhanced performance gains.