bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemanfaatan Digital Marketing Channel dalam Upaya Memperluas Pemasaran Produk Jahe Merah Instan Sarongge
Authors:   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Argawan Benjamin , Halim Budiyanto ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Wijaya Jessica ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Ekaputri Kartika ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Christian Aditia Kevin ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Rama Prasetya Nicolas ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Candra Trivaldi ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yuliat Retno ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

This paper aims to utilize the Digital Marketing Channel in terms of expanding the marketing of Sarongge Instant Red Ginger. this paper is based on the difficulties that partner’s experience upon doing the marketing and the usage of Digital Marketing Channel, and thus the authors feels that the brand awareness from the product is still very low. as for the reason of utilizing Digital Marketing Channel is aimed to overcomes the weaknesses that happens during the consignment such as the length of product turnover, the lack of network marketing, and the high cost of transportation in product distribution. By having the Digital Marketing Channel, authors finds the solution to resolve those problems by using platforms like Tokopedia, Instagram, and Whatsapp so that the product sales not only concentrated in the Cipanas area. With the use of Digital Marketing Channel, it is evident that the sales of Sarongge Instant Red Ginger increases by 66% and the products can be purchased by the community anytime.
Pengembangan Ekonomi Pusat Kegiatan Belajar Masyarakat Merpati Bangsa Melalui Usaha Makanan Ringan
Authors:   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Frandinata James , Renaldy Renaldy ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Kasih S Olivia ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Gunawan Hendry ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Angel Valencia ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Geraldo Timothy ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Faustine A Febiani ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Puspo Kuntjoro Antonius ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

Pusat Kegiatan Belajar Masyarakat (PKBM) is a social organization that aims as a means of community development. PKBM has various activities in it, one of which is the Business Learning Group (KBU) which is currently not running due to constraints in management. We as a group work together with PKBM in developing KBU activities so that the potential of PKBM community members can be maximized. Groups help in terms of operations, marketing, human resources, and finance. From an operational point of view focused on the snack products produced, in terms of marketing supported for consignment systems and sales with online media, in terms of human resources a management system is made so that it is organized and financially in order to record more details. This facilitator is expected to help the activities at the KBU which lead to the implementation of activities in PKBM in order to help social problems. The resulting product focuses on snacks, especially roll chips and chopsticks that do not require special abilities. HR Management is the main challenge for the group to determine the person in charge of the activities at KBU so that the business can run continuously. Making this management system in the KBU will be the main focus so that the community economy in PKBM can develop.
Peningkatan Produktivitas UMKM Kue Kering dan Tik Tuk di Desa Cipanas Melalui Program Pendampingan Community Development
Authors:   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Wiwa Soetijoso Winnie , Indira Saputera Miranda ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Anindhita Shabira ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Dwiputra Mahardika ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Andika Rivo ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Gerardo Erick ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Santosa Putra Aditya ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Paramita Kartika ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

The Community Development Program aims to help The Micro Small & Medium Enterprises (MSME) in developing their business. Through this activity, it is intended for builders to be able to increase sales and marketing widely. The method used is mentoring and monitoring of the direct practices applied by partners regarding the production process of cookies and tik-tuk. The success of this activity is in the form of a standard operating procedure (SOP). Partners also get additional equipment that supports the production process. Marketing partner products is made online to reach a broad target market. Product innovation starts from the presence of brands, logos, and packaging made to attract customers with new products introduced to the market.
FAKTOR-FAKTOR YANG MENGHALANGI PENJUALAN REMPEYEK SKALA KECIL
Authors:   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Airin Adelia , Aditya Alycia ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Ramly Audi ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Marcelo Michael ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Eltino .S Stanley ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Theodora Octavilla ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Puspos Kuntjoro Antonius ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

Rempeyek is one of the complementary food from Indonesia that has unique form, different texture, and it also has many different topping to make a rempeyek. Beside rempeyek, rengginang is also our job as a Prasetiya Mulya student in Community Development subject to improve their business and our partner name is Ibu Lilis. The first problem is that Ibu Lilis didn’t have a brand or logo, didn’t have a good neat product, didn’t have enough capital, lack of human resource, and lack of knowledge to make a financial records. The solution to increase small scale business and wider market were consignment strategy, create a new brand and logo, change the quality of the packaging to become more durable. Method that we used for this solution is SWOT. This is done by practicing directly with partners to provide knowledge about all aspects; marketing, finance, operations, and human resources to develop partner businesses to be more developed. Finally, The product that Ibu Lilis produced can grow to be better quality, have a structured financial report, and get higher profit than before.
STUDI DESKRIPTIF MANFAAT PEMBELAJARAN MATA KULIAH ELEKTIF COFFEE BUSINESS AND MANAGEMENT
Authors:   Universitas Prasetiya Mulya, Jakarta, Wijanarti Sri Widya , Kusmulyono Muhammad Setiawan ,   Universitas Prasetiya Mulya, Jakarta
Published: March 2022

The trend of coffee business has increased sharply in the last three years and has become a prospective business opportunity. One response to this trend is making courses on coffee business and management. This qualitative research method aims to evaluate the learning benefits of Coffee Business and Management elective courses in the Prasetiya Mulya University, S1 Business Program, in 2017-2018 academic year. The results of the study revealed that the majority of students who took this course argued that they have interests to know the coffee business and industry in Indonesia. The most interesting material in this course is dominated by practical learning about coffee in the laboratory. The most important result, 90% more students from Coffee Business and Management courses are inspired to run a coffee business.
Assessment of M5 model tree for prediction of azithromycin antibiotic removal by multi-wall carbon nanotubes in a fixed-bed column system
Authors: Amiri Mohammad Javad , Bahrami Mehdi , Rajabi Sara
Published: March 2022

In this research, an M5 model tree is employed for the prediction of removal efficiency of azithromycin antibiotics by multi-wall carbon nanotubes (MWCNTs), based on experimental data sets from a laboratory column mode. The effect of total flow time (0–260 min), influent flow rates (0.5, 1, and 1.5 mL min−1), bed depths (2, 4, and 6 cm), initial azithromycin concentrations (25, 50, and 100 mg L−1), and pHs (2, 4, 6, 8, and 10) was considered in the adsorption process. Based on the obtained structures, three linear equations (LM, LM2, and LM3) were developed. The root mean square error (RMSE) of 9.89% and determination coefficient (R2) of 0.946 were determined for predicting azithromycin removal by the M5 model tree. The results indicated that contact time was more important in the adsorption process, relative to other operating conditions. This research showed that the M5 model tree could be an accurate and faster alternative to the available mathematical models to estimate removal rates of pollutants. The results obtained from the FTIR technique confirmed that the O–H groups on the MWCNTs surface have an important role in azithromycin adsorption.
Comparing alternative PDA solvers with EPANET
Authors: Todini E. , Farina A. , Gabriele A. , Gargano R. , Rossman L. A.
Published: March 2022

This work compares several alternative methods of pressure-driven analysis (PDA) implemented within the code base of the EPANET water distribution system modeling software. The resulting code includes a direct method, the original and a newly modified version of the inverse method currently used by EPANET 2.2, and two recently published methods (the global gradient approach-based PDA and the active set method). The latter four methods solve PDA problems using an inverse flow–pressure relationship, whereas the direct method uses the original relationship. The alternative methods were extensively tested, and their performance was compared over several case study water distribution networks of vastly different sizes and complexities. The results showed that all of the new inverse methods are equally efficient and reliable, whereas the direct method is less reliable by having a higher frequency of failing to converge.
Characterization of reported legionellosis outbreaks associated with buildings served by public drinking water systems: United States, 2001–2017
Authors: Holsinger Hannah , Tucker Nicole , Regli Stig , Studer Kirsten , Roberts Virginia A. , Collier Sarah , Hannapel Elizabeth , Edens Chris , Yoder Jonathan S. , Rotert Kenneth
Published: March 2022

This study examined 184 legionellosis outbreaks in the United States reported to the Centers for Disease Control and Prevention's Waterborne Disease and Outbreak Surveillance System, from 2001 to 2017. Drinking water characteristics examined include source water type, disinfectant type, exposure setting, geographical distribution by U.S. Census Divisions, and the public water system size (population served). This study found that most of the reported drinking water-associated legionellosis outbreaks occurred in eastern United States, including 35% in the South Atlantic, 32% in the Middle Atlantic, and 16% in the East North Central Census Divisions were linked with building water systems in healthcare and hotel settings; and were associated with buildings receiving drinking water from public water systems serving >10,000 people. Targeted evaluations and interventions may be useful to further determine the combination of factors, such as disinfectant residual type and drinking water system size that may lead to legionellosis outbreaks.
Assessing the impacts of land use–land cover changes on direct surface runoff: a remote sensing approach in Khulna City
Authors: Das Palash Chandra , Esraz-Ul-Zannat Md.
Published: March 2022

The increased risks of storm flood occurrences in large cities are the result of land use changes due to rapid urbanization. This study examines the influence of land use changes in Khulna City Corporation (KCC) area on surface runoff over a period of 15 years, from 2005 to 2020. Land use–land cover (LULC) maps for 2005, 2010, 2015, and 2020 were created employing support vector machine (SVM)-based supervised image classification using time-series satellite data, and the surface runoff was determined using Soil Conservation Service-Curve Number model. The major land use change drivers of surface runoff were determined through a correlation analysis. Surface runoff was observed to follow a similar trend as that of impervious urban areas, which went up by 5.44% from 2005 to 2020 (17.00 mm increment in average runoff) and the opposite trend was found in vegetation land cover, which declined by 13.34% in areal extent throughout the study period. In comparison with other types of land use, surface runoff changes were most significantly associated with the changes in urban impervious areas and vegetation land use-land cover (LULC) class. In fast-growing cities across the world, and especially in developing nations, the results of this study may serve as a guide for urban storm flood management and urban planning efforts.
Immobilization of IMP-1 metallo-beta-lactamase on Fe3O4@SiO2 as nanobiocatalyst for degradation of beta-lactam antibiotics in wastewater
Authors: Shokoohizadeh Mohammad javad , Almasi Ali , Karami Farahnaz , Mousavi Seyyed Alireza , Khodarahmi Reza
Published: March 2022

Residues of antibiotics in water resources and wastewater have been significant environmental and public health problems. The current study developed a high-efficiency enzymatic nanobiocatalyst for the degradation of beta-lactam antibiotics. For this purpose, metallo-beta-lactamase IMP-1 was obtained by the cloned blaIMP gene overexpressed in Escherichia coli. 2.6 mg purified enzyme was used for immobilization on 100 mg modified Fe3O4 @ SiO2 magnetic nanoparticles. Immobilized IMP-1 showed similar storage stability to the free enzyme. The optimum temperatures and enzyme activity pH for free and immobilized enzymes were 70 °C and 60 °C, 7.5 and 6.5, respectively. In addition, after 15 reaction cycles, 80 percent of the enzyme activity was retained, according to a reusability analysis of the immobilized enzyme. For free and immobilized enzymes, the highest catalytic activity was observed for penicillin G and cephalexin, whereas Vmax/Km value for ceftriaxone was 3-fold (free enzyme) to 10-fold (immobilized enzyme) lower than for penicillin G. Also, the results showed that the immobilized IMP-1 on magnetic nanoparticles has an excellent ability to remove beta-lactam antibiotics from aqueous solutions. Thus, i could be an appropriate choice for removing beta-lactam antibiotics from pharmaceutical industry wastewater.
O SIMBÓLICO E SUAS MANIFESTAÇÕES
Authors: Oliveira de Menezes Leandro , Santos de Oliveira Simone
Published: March 2022

O debate territorial está longe de ter cessado, ou de ter alcançado uma unanimidade. Novos estudos sobre as questões territoriais são publicados frequentemente, apresentando discordâncias, complementações e favorecendo a ampliação das possibilidades de entendimento sobre o território, e aproximações com outras ciências, além da geográfica. Nesse sentido, o presente artigo se propõe a analisar a articulação da territorialidade e da memória no longa-metragem Narradores de Javé.  Trata-se de uma pesquisa qualitativa e descritiva, tendo a análise fílmica como método de investigação. Concluiu-se que a dimensão simbólica dos territórios se manifesta nos contextos sociais de diferentes formas, a territorialidade e a memória são duas delas, e estão interligadas.
Short term assessment of nutrients and physicochemical parameters considering different depths in a hypersaline lagoon – Araruama Lagoon –RJ
Authors: Trevisan Cleuza , Vicente Murilo , Pontes Gabriela , Carvalho Angelo , Mello-Guimarães Teresa , Pontes Juliana , Medeiros Hellen , Wasserman Julio
Published: March 2022

The Araruama lagoon water quality has deteriorated at an accelerated pace during the last decades, mainly due to an expansion of urban occupation. The nutrients input increased by domestic effluents could reach eutrophication, which may cause episodes of algal blooms and fish mortalities. The aim of this study was to evaluate the stratification of water parameters in the same sampling campaign. Eleven water samples were collected at the surface, middle, and bottom along the lagoon. For each sample, the following parameters were analyzed: biochemical oxygen demand (BOD5), dissolved oxygen (DO), turbidity, particulate organic carbon (POC), nitrogen and phosphorus (dissolved and particulate). The hydrodynamic characterization showed that regardless the connection with the ocean, a large part of the lagoon is more influenced by winds than tides. In general, parameters showed a homogeneous behavior along the water column. The results of DO and BOD5 confirmed that the lagoon is highly oxygenated. High phosphorus values combined with the result of the rates of nitrogen to phosphorus ratio (N:P) show that P is the limiting factor. The concentrations of BOD5, total nitrogen and total phosphorus, chlorophyll-a and phaeopigments corroborate this result.
Thiazole and Related Heterocyclic Systems as Anticancer Agents: A
Review on Synthetic Strategies, Mechanisms of Action and SAR Studies
Authors: Sahil  , Kaur Kamalpreet , Jaitak Vikas
Published: March 2022

Background:

Cancer is the second leading cause of death worldwide. Many
anticancer drugs are commercially available, but lack of selectivity, target specificity, cytotoxicity,
and development of resistance lead to serious side effects. Several experiments
have been going on to develop compounds with minor or no side effects.

Objective:

This review mainly emphasizes synthetic strategies, SAR studies, and mechanism
of action if thiazole, benzothiazole, and imidazothiazole-containing compounds as
anticancer agents.

Methods:

Recent literature related to thiazole and thiazole-related derivatives endowed
with encouraging anticancer potential is reviewed. This review emphasizes contemporary
strategies used for the synthesis of thiazole and related derivatives, mechanistic targets,
and comprehensive structural activity relationship studies to provide perspective into the
rational design of high-efficiency thiazole-based anticancer drug candidates.

Results:

Exhaustive literature survey indicated that thiazole derivatives are associated
with properties of inducing apoptosis and disturbing tubulin assembly. Thiazoles are also
associated with the inhibition of NFkB/mTOR/PI3K/AkT and regulation of estrogenmediated
activity. Furthermore, thiazole derivatives have been found to modulate critical
targets, such as topoisomerase and HDAC.

Conclusion:

Thiazole derivatives seem to be quite competent and act through various
mechanisms. Some of the thiazole derivatives, such as compounds 29, 40, 62, and 74a
with IC50 values of 0.05 μM, 0.00042 μM, 0.18 μM, and 0.67 μM, respectively, not only
exhibit anticancer activity, but they also have lower toxicity and better absorption. Therefore,
some other similar compounds could be investigated to aid in the development of
anticancer pharmacophores.
Effects of SVEP1 on Lung Squamous Cell Carcinoma and its Association
with Tumor Mutation Burden, Prognosis, and Immune Regulation
Authors: Luo Yu , Zhang Min , Wang Zhibo , Li Zhihua , Chen Xiru , Cao Juan , Que Jun , Chen Liang , Deng Xiaheng
Published: March 2022

Background:

The mutated genes in lung squamous cell carcinoma were investigated for
their possible association with tumor mutation burden, microsatellite instability, and cancer prognosis.

Objective:

Our study aims to evaluate the value of the candidate genes as a potential biomarker of
lung squamous cell carcinoma and pan-cancer analysis.

Methods:

The landscape of the tumor microenvironment and infiltrating lymphocytes in lung
squamous cell carcinoma was calculated using ESTIMATE and CIBERSORT algorithm. Weighed
gene co-expression network analysis was used to screen key modules related to immune cell infiltration.
Somatic mutations were found by data analysis from the TCGA and ICGC databases.
Mann-Whitney U test was used to evaluate the tumor mutation burden difference between patients
with mutant and wild-type SVEP1 genes. The Kaplan-Meier method was used to examine the
prognosis of the patients with mutations. The effects of SVEP1 expression on tumor mutation burden
and immunity in different cancers were determined by pan-cancer analysis.

Results:

SVEP1 mutation was found to be associated with a higher tumor mutation burden and
prognosis. SVEP1 mutation might be involved in the possible biological process of the anti-tumor
immune response. SVEP1 is related to different degrees of immune infiltration in cancer. Moreover,
the miRNA-SVEP1 targeting network was used to illuminate the possible mechanisms.

Conclusions:

SVEP1 mutation and its mRNA expression are related to tumor mutation burden and
cancer immunity in lung squamous cell carcinoma. Our findings reveal the underlying mechanisms,
indicating that SVEP1 may be a prognostic marker of lung squamous cell carcinoma.
miRNAs in SARS-CoV-2 Infection: An Update
Authors: Azhar Asim , Khan Wajihul Hasan , Al-Hosaini Khaled , Kamal Mohammad Amjad
Published: March 2022

Coronavirus disease-2019 (COVID-19) is a highly infectious disease caused by newly discovered severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the inception of SARS-CoV-2 in Wuhan, China, the
virus has traveled more than 200 countries globally. The role of SARS-CoV-2 in COVID-19 has been thoroughly
investigated and reviewed in the last 22 months or so; however, a comprehensive outline of miRNAs in SARS-CoV-
2 infection is still missing.
The genetic material of SARS-CoV-2 is a single-stranded RNA molecule nearly 29 kb in size. RNA is composed of
numerous sub-constituents RNA is found in the cells in a number of forms. including microRNAs (miRNAs). miRNAs
play an essential role in biological processes like apoptosis, cellular metabolism, cell death, cell movement,
oncogenesis, intracellular signaling, immunity, and infection. Lately, miRNAs have been involved in SARS-CoV-2
infection, though the clear demonstration of miRNAs in the SARS-CoV-2 infection is not fully elucidated. The present
review article summarizes recent findings of miRNAs associated with SARS-CoV-2 infection. We presented
various facets of miRNAs. miRNAs as the protagonists in viral infection, the occurrence of miRNA in cellular receptors,
expression of miRNAs in multiple diseases, miRNA as a biomarker, and miRNA as a therapeutic tool have been
discussed in detail. We also presented the vaccine status available in various countries.
The Marriage between Nanotechnology and Stem Cells Secretome for
COPD
Authors: Kharat Avinash , Sanap Avinash , Shekatkar Madhura , Kheur Supriya , Bhonde Ramesh
Published: March 2022

Chronic Obstructive Pulmonary Disease (COPD) is a disorder characterized by narrow alveoli as a result of emphysema. As such, there is no treatment to cure this disorder completely, and existing drugs only delay the progression of the disease. In recent years, the stem cell secretome as a drug is remarkably used as a regenerative therapy. In particular, cell-free therapy approaches offer great opportunities for the treatment of COPD. However, a few issues, such as the delivery of stem cell secretome as a drug to the alveolar region, have obstructed their application in clinical scales. To address these challenges, a combination of stem-cells secretome as a drug with nanotechnology could be a smart solution. We suggest that the combinational approach of delivering nanoparticles loaded with stem cell secretome could be a translational medicine approach for the successful outcome of COPD.
The Angiogenesis Effects of Electro-acupuncture Treatment via Exosomal
miR-210 in Cerebral Ischemia-Reperfusion Rats
Authors: Peng Yong-Jun , Xu Shu-Ying , Zeng Chun-Li , Ni Si-Ming
Published: March 2022

Background:

Acupuncture has been recommended as an alternative and complementary
therapy for preventing and treating cerebral ischemia by the World Health Organization (WHO) for
years. However, the mechanisms remain unclear. Accumulating evidence has shown that acupuncture
can promote angiogenesis to attenuate brain damage after ischemic stroke. In recent years, exosome-
carried microRNAs (miRNAs) activated by acupuncture have proven effective in regulating
pathological changes. We, therefore, investigated whether electro-acupuncture (EA) enhanced angiogenesis
in cerebral stroke via exosome-carried miR-210.

Methods:

We extracted and identified the exosomes from the serum of MCAO with EA treatment
and injected them into MCAO rats for further observation. Simultaneously, miR-120 siRNA and
HIF-1α inhibitor were transfected. Then, we evaluated the volume of infarction, pathological changes,
and expression levels of angiogenic related factors of each group of rats by TTC and HE staining,
transmission electron microscope (TEM), western blot, and quantitative PCR (qPCR).

Results:

Compared with the MCAO group, EA-Exosome (EA-EXO) treatment significantly decreased
the infarct volume and the pathological damage, but miR-210 siRNA or HIF-1α inhibitor
reversed the protective outcomes induced by EA-EXO. Moreover, EA-EXO treatment upregulated
miR-210 and increased CD34, HIF-1α, VEGF, Notch1 protein, and mRNA expressions compared to
the MCAO group. MiR-210 siRNA or HIF-1α inhibitor treatments both down-regulated those angiogenic
related proteins and mRNAs.

Conclusion:

EA treatment could activate the HIF-1α/VEGF/Notch 1 signal pathway to facilitate
angiogenesis after ischemic stroke via exosomal miR-210.
Self-assembled Nucleic Acid Nanostructures for Biomedical Applications
Authors: Chang Xu , Yang Qi , Lee Jungyeon , Zhang Fei
Published: March 2022

Structural DNA nanotechnology has been developed into a powerful method for creating self-assembled nanomaterials. Their compatibility with biosystems, nanoscale addressability, and programmable dynamic features make them appealing candidates for biomedical research. This review paper focuses on DNA self-assembly strategies and designer nanostructures with custom functions for biomedical applications. Specifically, we review the development of DNA self-assembly methods, from simple DNA motifs consisting of a few DNA strands to complex DNA architectures assembled by DNA origami. Three advantages are discussed using structural DNA nanotechnology for biomedical applications: (1) precise spatial control, (2) molding and guiding other biomolecules, and (3) using reconfigurable DNA nanodevices to overcome biomedical challenges. Finally, we discuss the challenges and opportunities of employing DNA nanotechnology for biomedical applications, emphasizing diverse assembly strategies to create a custom DNA nanostructure with desired functions.
Treatment Management of Diabetic Wounds Utilizing Herbalism: An
Overview
Authors: Sharma Shaweta , Kumari Priya , Sharma Pramod Kumar , Alam Aftab
Published: March 2022

Background and Objectives:

Diabetes Mellitus, commonly known as DM, is a metabolic
disorder which is characterized by high blood glucose level, i.e., chronic hyperglycemia. If it is not
managed properly, DM can lead to many severe complexities with time and can cause significant damage
to the kidneys, heart, eyes, nerves and blood vessels. Diabetic foot ulcers (DFU) are one of
those major complexities which affect around 15-25% of the population diagnosed with diabetes.
Due to diabetic conditions, the body's natural healing process slows down leading to longer duration
for healing of wounds only when taken care of properly. Herbal therapies are one of the approaches
for the management and care of diabetic foot ulcer, which utilizes the concept of synergism for better
treatment options. With the recent advancement in the field of nanotechnology and natural drug
therapy, a lot of opportunities can be seen in combining both technologies and moving towards a more
advanced drug delivery system to overcome the limitations of polyherbal formulations.

Methods:

During the writing of this document, the data was derived from existing original research
papers gathered from a variety of sources such as PubMed, ScienceDirect, Google Scholar.

Conclusion:

Hence, this review includes evidence about the current practices and future possibilities of
nano-herbal formulation in treatment and management of diabetic wounds.
The Value of Ultrasonography in Predicting Acute Gangrenous Cholecystitis
Authors: Peng Yanhui , Liu Yifan , Xue Dongdong
Published: March 2022

Acute cholecystitis is a common clinical inflammatory lesion of the gallbladder. With the
aggravation of inflammation, ischemic, necrosis, and even acute gangrenous cholecystitis occur in the
gallbladder. At the same time, a variety of complications appear, seriously affecting the prognosis of
patients. It is recommended that ultrasound can be utilized as the first choice for the diagnosis of acute
cholecystitis, due to its fastness, convenience, non-radiation, and low cost. Here, we summarize the
latest progress that can predict acute gangrenous cholecystitis in ultrasound, thus assisting us in identifying
patients with high risk of gangrene in early stage, and treating these patients in time.
Current Progress and Perspectives of CDC20 in Female
Reproductive Cancers
Authors: Ni Ke , Hong Li
Published: March 2022

The cancers of the cervix, endometrium, ovary, and breast are great threats
to women’s health. Cancer is characterized by the uncontrolled proliferation of cells and
deregulated cell cycle progression is one of the main causes of malignancy. Agents
targeting cell cycle regulators may have potential anti-tumor effects. CDC20 (cell division
cycle 20 homologue) is a co-activator of the anaphase-promoting complex/cyclosome
(APC/C) and thus acts as a mitotic regulator. In addition, CDC20 serves as a subunit of
the mitotic checkpoint complex (MCC) whose function is to inhibit APC/C. Recently,
higher expression of CDC20 has been reported in these cancers and was closely
associated with their clinicopathological parameters, indicating CDC20 a potential target
for cancer treatment that is worth further study. In the present review, we summarized
current progress and put forward perspectives of CDC20 in female reproductive
cancers.
The Protective Effects of the Combination of Vitamin E and Swimming Exercise on Memory Impairment Induced by Exposure to Waterpipe Smoke
Authors: Alzoubi Karem H. , Halboup Abdulsalam M. , Khabour Omar F. , Alomari ⁠ Mahmoud A.
Published: March 2022

Background:

Waterpipe smoking (WP) exposure involves a negative health impact, including memory deficit, which is attributed to the elevation of oxidative stress. Vitamin E (VitE) in combination with swimming exercise exerts protective effects that prevent memory impairment. In the current study, the modulation of WP-induced memory impairment by the combined effect of VitE and swimming exercise (SE) was investigated.

Method:

Animals were exposed to WP one hour/day, five days per week for four weeks. Simultaneously, VitE (100 mg/kg, six days/week for four weeks) was administered via oral gavage, and the rats were made to swim one hour/day, five days/week for four weeks. Changes in memory were evaluated using radial arm water maze (RAWM), and oxidative stress biomarkers were examined in the hippocampus.

Results:

WP exposure induced short-term/long-term memory impairment (p<0.05). This impairment was prevented by a combination of VitE with SE (p<0.05). Additionally, this combination normalized the hippocampal catalase, GPx, and GSH/GSSG ratios that were modulated by WP (p<0.05). The combination further reduced TBARs levels below those of the control group (p<0.05).

Conclusion:

WP-induced memory impairments were prevented by the combination of VitE with SE. This could be attributed to preserving the hippocampal oxidative mechanism by combining VitE and SE during WP exposure.
Vaccine Efficacy Denial: A Growing Concern Affecting Modern Science,
and Impacting Public Health
Authors: Signorini Luca , Ceruso Francesco Maria , Aiello Elisabetta , Zullo Maria Josephine , De Vito Danila
Published: March 2022

Background:

The discovery of the vaccination technique was revealed by Edward Jenner in 1796, which represented the first scientific attempt to control an infectious disease by vaccines, followed by other important studies carried out by Pasteur and Koch, and Sabin, who developed the first technique to attenuate the virus. In recent decades, numerous scholars have begun to create dangerous theories against the effectiveness of vaccines through scientifically invalid or fraudulent studies.

Aim:

This critical review of the literature aims to analyze the main factors that have undermined the credibility of vaccines in the general population, disproved false information and emphasized the benefits of vaccines over the last 200 years.

Discussions:

Unfortunately, several studies have been carried out without the proper scientific attention. The most impacting example is the study published by Andrew Wakefield in the Lancet journal who tried to correlate vaccines with the development of autism: this publication was withdrawn from the journal a few years after its publication, but the impact of incorrect scientific studies, fake news, and ambiguous healthcare policies have led to a general adverse opinion about the effectiveness of vaccines.

Conclusion:

The excess of uncontrolled information is a serious concern during the Coronavirus pandemic. Modern science must tackle this problem with a better willingness to communicate the clinical studies to those who cannot understand medical information. Nevertheless, a reliable science must also limit the distribution of studies that do not meet the basic criteria of methodological rigor and certainty of results in order not to incur confusion in the scientific community.
Recent Advances on Anti-interference Control Strategies for Better Operation
Authors: Gao Bingwei , Ye Yongtai , Guan Hao , Sheng Wei
Published: March 2022

Background:

Under the influence of complex external environment and the internal parameter
perturbation of the system itself, many interference problems hinder the development of the
controlled object according to the predetermined trajectory.

Objective:

The objective of this study is to provide the corresponding anti-interference control
methods for different degrees of interference and introduce their respective characteristics.

Methods:

This paper mainly summarizes the application examples of anti-interference control algorithms
in the face of different interference problems, which are mainly divided into three categories.
Especially two new concepts, whose names are composite anti-interference control and innovative
anti-interference control algorithm design, are presented. At the same time, this paper not only
summarizes the outstanding contribution of anti-interference control in the mechanical field, but
also expounds on the application examples of coupling of anti-interference control in electrical aspect
and describes the application of anti-interference control in other planets.

Results:

From the interference problem on the earth to the anti-interference control of outer space,
the control algorithm shows the unique charm step by step. In the future, to cope with the complex
and changeable environment, the anti-interference algorithm will continue to be optimized in depth,
letting the control system run steadily in direction of fast, accurate and stable on the expected track.

Conclusion:

Anti-interference control plays an important practical role in the control of systems.
Whether in the mechanical field or coupling in other aspects such as electrical, it can help the system
run better according to the needs of the controller. It is effective and reasonable to combine different
strategies for the systems, so that the systems are more accurate and stable.
Feeling Loki's Pain: Designing and Evaluating a DIY 3D Auditory Display for Geodata Sonification
Authors: Lindborg PerMagnus
Published: March 2022

Loki’s Pain is an immersive 3D audio installation artwork, a sonification of seismic activity. Visitors take the place of Loki, who was punished by the gods and caused earthquakes. We designed an auditory display in the shape of a hemi-dodecahedron and built a prototype with a low-budget, DIY approach. Seismic data were retrieved from the Internet. Location, magnitude, and epicentre depth of hundreds of recent earthquakes were sonified with physical modelling synthesis into a 10-minute piece. The visitor experience was evaluated in a listening experiment (N = 7), comparing the installation with a version for headphones. Differences on eight semantic scales were small. A content analysis of focus group discussions nuanced the investigated topics, and qualitative interpretation strengthened the quantitative findings. Verbal expressions of immersivity were stronger in the installation, which stimulated longer and more detailed responses. Aspects such as audio quality, the structure's physical-visual shape, and multisensorial design evoked both positive and negative emotions, and elicited imagination and memory recall. However, the assumed capacity of the LOKI structure to stimulate a richer social experience than that of headphone listening was not supported by the responses in this study.
Towards a Better Understanding of Mental Models Implied in Sonic Icon Design and Perception
Authors: Bouchara Tifanie , Bouchet Mathieu , Misdariis Nicolas
Published: March 2022

This paper presents our ongoing efforts to determine if there are shared references, i.e. mental models, across designers and potential users of sonic icons in mobile applications. First, 13 sound designer students had to conceive sonic icons regarding 11 common mobile functionalities. Their conceptual models were analyzed through lexical analyses of their self-report on their design and manual annotations of their renderings. Second, the 143 obtained icons were evaluated by 52 naïve listeners through a free categorization task. While deeper analyses are still required, results already indicate that some function/sonic icon links make strong consensus on how they should be realized, considering both the designers’ productions and the listeners’ clustering. This forms one key result of the study and could lead to useful guidelines in sonic icon design.
Layers of Meaning: The Ocean’s Natural Acoustics and the Music of Its Datasets
Authors: Spence Heather Ruth , Ballora Mark
Published: March 2022

The transdisciplinary National Academies Keck Futures Initiative (NAKFI) conference on the Deep Blue Sea sparked a collaboration between sonification expert Mark Ballora and marine biologist and sound artist Heather Spence. Research involving long-term Marine Passive Acoustic Monitoring (MPAM) of the MesoAmerican Reef system forms the basis for a gradient of audio products: 1) layering a tour guide acoustic instrument over raw and manipulated soundscape recordings; 2) layering of multiple acoustic instruments over duty cycle interpretation sampling; and 3) layering of data sonification over the original data, with additional acoustic instrument layers. The audio products are designed to promote data exploration and understanding by researchers and students, as well as an emotional impact musically with conservation themes. Presentations have included live and virtual performances and workshops. Next steps include sonification of other correlated environmental data with the original sound data in raw, manipulated, and sonified forms.
Introduction of a Computational Modelling Approach to Auditory Display Research: Case Studies Using the QN-MHP Framework
Authors: Jeon Myounghoon , Nadri Chihab , Zhang Yiqi
Published: March 2022

For more than two decades, a myriad of design and research methods have been proposed in the ICAD community. Neurological methods have been presented since the inception of ICAD, and psychological human-subjects research has become as a legitimate approach to auditory display design and evaluation. However, little research has been conducted on modelling approaches to formalize human behavior in response to auditory displays. To bridge this gap, the present paper introduces computational modelling in auditory displays using the Queuing Network-Model Human Processor (QN-MHP) framework. After delineating the advantages of computational modelling and the QN-MHP framework, the paper introduces four case studies, which modelled drivers’ behavior in response to in-vehicle auditory warnings, followed by the implications and future work. We hope that this paper can spark lively discussions on computational modelling in the ICAD community and thus, more researchers can benefit from using this method for future research.
Mapping Inter-Cardiovascular Time-Frequency Coherence to Harmonic Tension in Sonification of Ensemble Interaction Between a Covid-19 Patient and the Medical Team
Authors: Frid Emma , Orini Michele , Martinelli Giampaolo , Chew Elaine
Published: March 2022

This paper presents exploratory work on sonic and visual representations of heartbeats of a COVID-19 patient and a medical team. The aim of this work is to sonify heart signals to reflect how a medical team comes together during a COVID-19 treatment, i.e. to highlight other aspects of the COVID-19 pandemic than those usually portrayed through sonification, which often focuses on the number of cases. The proposed framework highlights synergies between sound and heart signals through mapping between time-frequency coherence (TFC) of heart signals and harmonic tension and dissonance in music. Results from a listening experiment suggested that the proposed mapping between TFC and harmonic tension was successful in terms of communicating low versus high coherence between heart signals, with an overall accuracy of 69%, which was significantly higher than chance. In the light of the performed work, we discuss how links between heart- and sound signals can be further explored through sonification to promote understanding of aspects related to cardiovascular health.
Investigating the Effects of Earcon and Speech Variables on Hybrid Auditory Alerts at Rail Crossings
Authors: Nadri Chihab , Lee Seul Chan , Kekal Siddhant , Li Yinjia , Li Xuan , Lautala Pasi , Nelson David , Jeon Myounghoon
Published: March 2022

Despite rail industry advances in reducing accidents at Highway Rail Grade Crossings (HRGCs), train-vehicle collisions continue to happen. The use of auditory displays has been suggested as a countermeasure to improve driver behavior at HRGCs, with prior research recommending the use of hybrid sound alerts consisting of earcons and speech messages. In this study, we sought to further investigate the effect of auditory variables in hybrid sound alerts. Nine participants were recruited and instructed to evaluate 18 variations of a hybrid In-Vehicle Auditory Alert (IVAA) along 11 subjective ratings. Results showed that earcon speed and pitch contour design can change user perception of the hybrid IVAA. Results further indicated the influence of speech gender and other semantic variables on user assessment of HRGC IVAAs. Findings of the current study can also inform and instruct the design of appropriate hybrid IVAAs for HRGCs.
ATHsENSe: A Multisensory Outdoor Installation
Authors: Drymonitis Alexandros , Charitos Dimitrios
Published: March 2022

The ATHsENSe installation is a four part AV installation based on environmental data from the city of Athens. It comprises four different installations: a visualization projection of the data, a sound installation where the data are being sonified, an installation comprising eight LED displays projecting texts from users of the web app of ATHsENSe, and a light installation reflecting the sound levels of a central point of Athens. The second of the four installations is presented here where data concerning CO, CO2, humidity and others, together with texts provided by the web app users, are being sonified in a six-channel surround installation. In addition to the electronic sounds of the sonification, four kinetic sculptures are being triggered by the system which create acoustic sounds by hitting found objects. This installation is located at the Serafeio complex in Athens, and was commissioned to the Spatial Research Media Group by the municipality of Athens after their successful participation in the Interventions in the City competition.