bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Cell Testing Topologies for Defect Detection Using Electrochemical Impedance Spectroscopy: A Combinatorial Experiment-Based Analysis
Authors: Ank Manuel , Göhmann Jonas , Lienkamp Markus
Published: August 2023

Given the increasing use of lithium-ion batteries, which is driven in particular by electromobility, the characterization of cells in production and application plays a decisive role in quality assurance. The detection of defects particularly motivates the optimization and development of innovative characterization methods, with simultaneous testing of multiple cells in the context of multi-cell setups having been researched to economize on the number of cell test channels required. In this work, an experimental study is presented demonstrating the influence of a defect type in one cell on five remaining interconnected cells in eight combinatorially varied topologies using galvanostatic electrochemical impedance spectroscopy. The results show that regularities related to the interconnection position are revealed when considering the change in the specific resistance ZIM,min at the transition from the charge transfer to the diffusion region between the reference and fault measurements, allowing it to function as a defect identifier in the present scenario. These results and the extensive measurement data provided can serve as a basis for the evaluation and design of multi-cell setups used for simultaneous impedance-based lithium-ion cell characterizations.
Research on the Internal Flow Field of Left Atrial Appendage and Stroke Risk Assessment with Different Blood Models
Authors: Yang Jun , Bai Zitao , Song Chentao , Ding Huirong , Chen Mu , Sun Jian , Liu Xiaohua
Published: August 2023

Extant clinical research has underscored that patients suffering from atrial fibrillation (AF) bear an elevated risk for stroke, predominantly driven by the formation of thrombus in the left atrial appendage (LAA). As such, accurately identifying those at an increased risk of thrombosis becomes paramount to facilitate timely and effective treatment. This study was designed to shed light on the mechanisms underlying thrombus formation in the LAA by employing three-dimensional (3D) left atrium (LA) models of AF patients, which were constructed based on Computed Tomography (CT) imaging. The distinct benefits of Computational Fluid Dynamics (CFD) were leveraged to simulate the blood flow field within the LA, using three distinct blood flow models, both under AF and sinus rhythm (SR) conditions. The potential risk of thrombus formation was evaluated by analyzing the Relative Residence Time (RRT) and Endothelial Cell Activation Potential (ECAP) values. The results gleaned from this study affirm that all three blood flow models align with extant clinical guidelines, thereby enabling an effective prediction of thrombosis risk. However, noteworthy differences emerged when comparing the intricacies of the flow field and thrombosis risk across the three models. The single-phase non-Newtonian blood flow model resulted in comparatively lower residence times for blood within the LA and lower values for the Oscillatory Shear Index (OSI), RRT, and ECAP within the LAA. These findings suggest a reduced thrombosis risk. Conversely, the two-phase non-Newtonian blood flow model exhibited a higher residence time for blood and elevated RRT value within the LAA, suggesting an increased risk for thrombosis.
Combined Use of a Bacterial Consortium and Early-Colonizing Plants as a Treatment for Soil Recovery after Fire: A Model Based on Los Guájares (Granada, Spain) Wildfire
Authors: Niza Costa Marla , Gil Tatiana , Teixeira Raquel , Rodrígues dos Santos Ana Sofía , Rebelo Romão Inês , Sequero López Cristina , Vílchez Juan Ignacio
Published: August 2023

During 2022, intense heat waves, together with particularly extreme dry conditions, created a propitious scenario for wildfires, resulting in the area of vegetation consumed in Europe doubling. Mediterranean countries have been particularly affected, reaching 293,155 hectares in Spain, the worst data in the last 15 years. The effects on the vegetation and the soil are devastating, so knowing the recovery factors is essential for after-fire management. Resilient microorganisms play a fundamental role in rapid nutrient recycling, soil structure, and plant colonization in fire-affected soils. In this present work, we have studied emergent microbial communities in the case of the Los Guájares (Granada, Spain) fire, one of the most extensive of the year, to evaluate their role in the recovery of soil and vegetation cover. We aim to discern which are the main actors in order to formulate a new treatment that helps in the ecosystem recovery. Thus, we have found the relevant loss in phosphorous and potassium solubilizers, as well as siderophores or biofilm producers. Here, we decided to use the strains Pseudomonas koreensis AC, Peribacillus frigoritolerans CB, Pseudomonas fluorescens DC, Paenibacillus lautus C, Bacillus toyonensis CD, and Paenarthrobacter nitroguajacolicus AI as a consortium, as they showed most of the capacities required in a regenerative treatment. On the other hand, the microcosm test showed an enhanced pattern of germination of the emerging model plant, Bituminaria bituminosa, as well as a more aggregated structure for soil. This new approach can create a relevant approach in order to recover fire-affected soils in the future.
Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life
Authors: Kabbani Noura , Stepan Holger , Blüher Matthias , Ebert Thomas , Baber Ronny , Vogel Mandy , Kiess Wieland , Stumvoll Michael , Breitfeld Jana , Lössner Ulrike , Tönjes Anke , Schrey-Petersen Susanne
Published: August 2023

Transforming growth factor beta-1 (TGFβ1) is an adipokine secreted from adipose tissue, placental tissue and immune cells with a role in cell proliferation, cell apoptosis and angiogenic proliferation. The role of TGFβ1 in pregnancy and child growth and the source of cord TGFβ1 are yet unknown. In this study, we sought to clarify the correlation of TGFβ1 levels with parameters of intrauterine growth and child growth during the first year of life, and to determine whether their source is primarily of fetal or maternal origin. Serum samples and anthropometric measurements were obtained from the LIFE Child cohort of 79 healthy mother–child pairs. Measurements were conducted using enzyme-linked immunosorbent assays. Statistical analyses including Mann–Whitney U-test, correlation analyses and linear regression analyses were performed using GraphPad Prism and R. TGFβ1 levels were significantly higher in cord than in maternal serum, suggesting a fetal origin. Multivariate regression analyses revealed strong positive associations between cord TGFβ1 levels at birth and child weight at U6. Furthermore, cord TGFβ1 was significantly correlated with child weight at approximately one year of age. An increase of 10,000 pg/mL in cord TGFβ1 concentrations at birth was associated with a higher body weight of 201 g at roughly one year of age when adjusted for sex.
Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth
Authors: Gu Lixiang , Ren Xingcong , Ngule Chrispus , Xiong Xiaofang , Song Jianxun , Li Zhiguo , Yang Jin-Ming
Published: August 2023

Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study identifies a novel NAC1-NF-κB signaling axis in melanoma, offering a promising new therapeutic option to treat melanoma.
Lowered Delta Activity in Post-COVID-19 Patients with Fatigue and Cognitive Impairment
Authors: Ortelli Paola , Quercia Angelica , Cerasa Antonio , Dezi Sabrina , Ferrazzoli Davide , Sebastianelli Luca , Saltuari Leopold , Versace Viviana , Quartarone Angelo
Published: August 2023

In post-COVID-19 syndrome (PCS), neurocognitive symptoms and fatigue are often associated with alterations in electroencephalographic (EEG) activity. The present study investigates the brain source activity at rest in PCS patients (PCS-pts) perceiving cognitive deficits and fatigue. A total of 18 PCS-pts and 18 healthy controls (HCs) were enrolled. A Montreal Cognitive Assessment (MoCA), Perceived Cognitive Difficulties Scale (PDCS) and Fatigue Severity Scale (FSS) were administered for assessing the symptoms’ severity. Brain activity at rest, both with open (OE) and closed eyes (CE), was recorded by high-density EEG (Hd-EEG) and localized by source estimation. Compared to HCs, PCS-pts exhibited worse performance in executive functions, language and memory, and reported higher levels of fatigue. At resting OE state, PCS-pts showed lower delta source activity over brain regions known to be associated with executive processes, and these changes were negatively associated with PDCS scores. Consistent with recent literature data, our findings could indicate a dysfunction in the neuronal networks involved in executive functions in PCS-pts complaining of fatigue and cognitive impairment.
Early-Stage Detection of Biotic and Abiotic Stress on Plants by Chlorophyll Fluorescence Imaging Analysis
Authors: Moustaka Julietta , Moustakas Michael
Published: August 2023

Most agricultural land, as a result of climate change, experiences severe stress that significantly reduces agricultural yields. Crop sensing by imaging techniques allows early-stage detection of biotic or abiotic stress to avoid damage and significant yield losses. Among the top certified imaging techniques for plant stress detection is chlorophyll a fluorescence imaging, which can evaluate spatiotemporal leaf changes, permitting the pre-symptomatic monitoring of plant physiological status long before any visible symptoms develop, allowing for high-throughput assessment. Here, we review different examples of how chlorophyll a fluorescence imaging analysis can be used to evaluate biotic and abiotic stress. Chlorophyll a is able to detect biotic stress as early as 15 min after Spodoptera exigua feeding, or 30 min after Botrytis cinerea application on tomato plants, or on the onset of water-deficit stress, and thus has potential for early stress detection. Chlorophyll fluorescence (ChlF) analysis is a rapid, non-invasive, easy to perform, low-cost, and highly sensitive method that can estimate photosynthetic performance and detect the influence of diverse stresses on plants. In terms of ChlF parameters, the fraction of open photosystem II (PSII) reaction centers (qp) can be used for early stress detection, since it has been found in many recent studies to be the most accurate and appropriate indicator for ChlF-based screening of the impact of environmental stress on plants.
YY1 Knockdown Relieves the Differentiation Block and Restores Apoptosis in AML Cells
Authors: Noguera Nelida Ines , Travaglini Serena , Scalea Stefania , Catalanotto Caterina , Reale Anna , Zampieri Michele , Zaza Alessandra , Ricciardi Maria Rosaria , Angelini Daniela Francesca , Tafuri Agostino , Ottone Tiziana , Voso Maria Teresa , Zardo Giuseppe
Published: August 2023

In this study we analyzed the expression of Yin and Yang 1 protein (YY1), a member of the noncanonical PcG complexes, in AML patient samples and AML cell lines and the effect of YY1 downregulation on the AML differentiation block. Our results show that YY1 is significantly overexpressed in AML patient samples and AML cell lines and that YY1 knockdown relieves the differentiation block. YY1 downregulation in two AML cell lines (HL-60 and OCI-AML3) and one AML patient sample restored the expression of members of the CEBP protein family, increased the expression of extrinsic growth factors/receptors and surface antigenic markers, induced morphological cell characteristics typical of myeloid differentiation, and sensitized cells to retinoic acid treatment and to apoptosis. Overall, our data show that YY1 is not a secondary regulator of myeloid differentiation but that, if overexpressed, it can play a predominant role in myeloid differentiation block.
Unravelling the Complexity of Colorectal Cancer: Heterogeneity, Clonal Evolution, and Clinical Implications
Authors: Saoudi González Nadia , Salvà Francesc , Ros Javier , Baraibar Iosune , Rodríguez-Castells Marta , García Ariadna , Alcaráz Adriana , Vega Sharela , Bueno Sergio , Tabernero Josep , Elez Elena
Published: August 2023

Colorectal cancer (CRC) is a global health concern and a leading cause of death worldwide. The disease’s course and response to treatment are significantly influenced by its heterogeneity, both within a single lesion and between primary and metastatic sites. Biomarkers, such as mutations in KRAS, NRAS, and BRAF, provide valuable guidance for treatment decisions in patients with metastatic CRC. While high concordance exists between mutational status in primary and metastatic lesions, some heterogeneity may be present. Circulating tumor DNA (ctDNA) analysis has proven invaluable in identifying genetic heterogeneity and predicting prognosis in RAS-mutated metastatic CRC patients. Tumor heterogeneity can arise from genetic and non-genetic factors, affecting tumor development and response to therapy. To comprehend and address clonal evolution and intratumoral heterogeneity, comprehensive genomic studies employing techniques such as next-generation sequencing and computational analysis are essential. Liquid biopsy, notably through analysis of ctDNA, enables real-time clonal evolution and treatment response monitoring. However, challenges remain in standardizing procedures and accurately characterizing tumor subpopulations. Various models elucidate the origin of CRC heterogeneity, highlighting the intricate molecular pathways involved. This review focuses on intrapatient cancer heterogeneity and genetic clonal evolution in metastatic CRC, with an emphasis on clinical applications.
Conventional Transarterial Chemo embolization Using Streptozocin in Patients with Unresectable Neuroendocrine Liver Metastases
Authors: Fohlen Audrey , Beaudouin Remi , Alvès Arnaud , Bouhier-Leporrier Karine , Pasik Christophe , Pelage Jean-Pierre
Published: August 2023

Background: The purpose of this study was to evaluate the clinical, biological and radiological responses to, and tolerability of, conventional transarterial chemoembolization (cTACE) using streptozocin for unresectable neuroendocrine liver metastases. Patients and Methods: A total of 52 patients with predominant liver disease were treated with cTACE using an emulsion of streptozocin, Lipiodol and embolization particles. A sequential approach was favored in patients with high liver tumor burden. Clinical, biological and radiological responses were evaluated using carcinoid symptoms, biomarkers and mRecist criteria, respectively. Results: A total of 127 procedures were performed with a sequential approach in 65% of patients. All patients received streptozocin and Lipiodol. Carcinoid syndrome was improved in 69% of patients after treatment (p = 0.01). Post-embolization syndrome was reported in 78% of patients. At the end of all cTACE, objective response and non-progressive disease were 32% and 70%, respectively. Progression-free survival was 18.3 ± 13.3 months (median 14.9) and median overall survival (OS) from start of treatment was 74 months. The OS at 1 year, 2 years, 3 years and 5 years was 91% (IC = 84–99%), 84% (CI = 72–95%), 69% (CI = 53–84%) and 63% (C = 46–81%), respectively. Conclusions: cTACE using streptozocin is an effective and well-tolerated palliative option for patients with neuroendocrine liver metastases, associated with prolonged survival and delayed time to progression.
New Functionalized Chitosan with Thio-Thiadiazole Derivative with Enhanced Inhibition of Pathogenic Bacteria, Plant Threatening Fungi, and Improvement of Seed Germination
Authors: Ibrahim Ahmed G. , Elgammal Walid E. , Eid Ahmed M. , Alharbi Maha , Mohamed Ahmad E. , Alayafi Aisha A. M. , Hassan Saber M. , Fouda Amr
Published: August 2023

In this study, a new modified chitosan conjugate (Chito-TZ) was developed via amide coupling between the acid chloride derivative of the methylthio-thidiazole compound and the free primary amino groups of chitosan. The product was characterized using several instrumental investigations, including Fourier-transform infrared spectroscopy (FT-IR), 1H-Nuclear magnetic resonance, X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). XRD indicated that the crystalline pattern of chitosan was interrupted after chemical modification with the thiadiazole derivative. Broido’s model was used to determine the thermal activation energy Ea, and the results showed that the Ea for the first decomposition region of Chito-TZ is 24.70 KJ mol−1 lower than that required for chitosan (95.57 KJ mol−1), indicating the accelerating effect of the thiadiazole derivative on the thermal decomposition of Chito-TZ. The modified chitosan showed better antibacterial and antifungal activities than the non-modified chitosan; except for seed germination, chitosan was better. The Chito-TZ showed a low MIC value (25–50 µg mL−1) compared to Chito (50–100 µg mL−1). Moreover, the maximum inhibition percentages for plant-pathogenic fungi, Aspergillus niger, Fusarium oxysporum, and Fusarium solani, were attained at a concentration of 300 µg mL−1 with values of 35.4 ± 0.9–39.4 ± 1.7% for Chito and 45.2 ± 1.6–52.1 ± 1.3% for Chito-TZ. The highest germination percentages (%) of broad bean, shoot and root length and weight, and seed vigor index were obtained after Chito treatment with a concentration of 200 µg mL−1 compared to Chito-TZ.
Mechanochemistry through Extrusion: Opportunities for Nanomaterials Design and Catalysis in the Continuous Mode
Authors: Trentin Oscar , Polidoro Daniele , Perosa Alvise , Rodríguez-Castellon Enrique , Rodríguez-Padrón Daily , Selva Maurizio
Published: August 2023

The potentialities of mechanochemistry trough extrusion have been investigated for the design of nanosized catalysts and their use in C-C bond-forming reactions. The mechanochemical approach proved successful for the synthesis of supported palladium nanoparticles with mean diameter within 6–10 nm, achieved by the reduction of Pd(II) acetate with ethylene glycol, in the absence of any solvent. A mesoporous N-doped carbon derived from chitin as a renewable biopolymer, was used as a support. Thereafter, the resulting nanomaterials were tested as catalysts to implement a second extrusion based-protocol for the Suzuki-Miyaura cross-coupling reaction of iodobenzene and phenylboronic acid. The conversion and the selectivity of the reaction were 81% and >99%, respectively, with a productivity of the desired derivative, biphenyl, of 41 mmol gcat−1 h−1.
Specific Learning Disorders (SLD) and Behavior Impairment: Comorbidity or Specific Profile?
Authors: Chieffo Daniela Pia Rosaria , Arcangeli Valentina , Moriconi Federica , Marfoli Angelica , Lino Federica , Vannuccini Sofia , Marconi Elisa , Turrini Ida , Brogna Claudia , Veredice Chiara , Antonietti Alessandro , Sani Gabriele , Mercuri Eugenio Maria
Published: August 2023

Introduction: Specific Learning Disorder (SLD) is a neurodevelopmental disorder characterized by difficulties in perceiving and processing verbal and non-verbal information. It is usually accompanied by impaired academic skills leading to school dropout and emotional disturbances, resulting in significant distress and behavioral problems. Methods: A cognitive, academic, and emotional-behavioral assessment was performed at T0 and T1 in children and adolescents with SLD. Participants received psychotherapy and speech therapy treatment from T0 to T1. Results: In SLD, the most compromised cognitive functions were working memory and writing skills. An impact on academic abilities was found. Children and adolescents with SLD experience greater anxiety and depression levels compared to their control peers. Conclusions: SLD may adversely influence psychological well-being. To counteract such a consequence, more specific cognitive and academic skill-oriented strategies should be taken into consideration.
Thin Cationic Polymer Coatings against Foodborne Infections
Authors: Yushina Yuliya K. , Sybachin Andrey V. , Kuznecova Oksana A. , Semenova Anastasia A. , Tolordava Eteri R. , Pigareva Vladislava A. , Bolshakova Anastasiya V. , Misin Vyacheslav M. , Zezin Alexey A. , Yaroslavov Alexander A. , Bataeva Dagmara S. , Kotenkova Elena A. , Demkina Elena V. , Reshchikov Maksim D.
Published: August 2023

Biocidal coatings are known to minimize or terminate development of bacterial and fungicidal infections. In this paper, biocidal activity of seven cationic (co)polymers with amino groups—polyethyleneimine, polyallylamine, polydiallyldimethylammonium chloride/polyhexamethylene guanidine copolymer, diallyldimethylammonium chloride/SO2 copolymer, linear and hyperbranched epichlorohydrin/dimethylamine copolymers, polydiallyldimethylammonium chloride—were tested toward Gram-positive and Gram-negative cells. The polymers showed a significant biocidal effect in both aqueous solution and after formation of polymer films on the hydrophilic glass plates. Polymer films were almost completely removed by water during 10 wash-off cycles, that finally resulted in the ultrathin monolayers with a thickness of several nanometers. A polyethyleneimine film showed the most resistance to water with a 50% loss after three wash-off cycles and 75% loss after six wash-off cycles. Binding and subsequent deactivation of pathogenic microorganisms occurs on the outer surface of cationic polymer films. It is expected that a gradual polymer wash-off will allow renewal of the outer film surface and thereby restore the biocidal properties of the polycationic coatings, including those with a nanoscale thickness.
Insights into Interfacial Features of Metal/Eco-Composites Designed for Energy Storage
Authors: Albu Raluca Marinica , Barzic Andreea Irina , Asandulesa Mihai , Rusu Bogdan-George , Stoica Iuliana , Sava Ion
Published: August 2023

The development of innovative materials with improved properties is required for the field of energy storage. This article proves that it is possible to utilize bio-derived fillers to tune the performance of biodegradable polymers. For this scope, eco-composites were attained by loading several amounts of walnut leaf powder (WLP) in hydroxyethylcellulose (HEC). Basic testing was conducted to emphasize the sample’s suitability for the pursued application. The rheological behavior was altered with the addition of WLP at low shear rates, which became more pseudoplastic, resulting in composite films with higher thickness uniformity. Wettability characteristics were used to analyze the macro-level adhesion of the platinum-containing samples, and the results showed that the presence of WLP led to the augmentation of interfacial compatibilization of the composite with the metal layer. The electron microscopy and atomic force microscopy scans showed the proper distribution of the WLP in the matrix. Local adhesion data derived from DFL-height curves further showed that the inclusion of WLP improves the adhesion capabilities at the nanoscale. The dielectric spectroscopy tests proved that the used biofiller leads to an enhancement in the permittivity of the composite with respect to the neat HEC. By accounting for all results, the generated eco-composites are suggested as alternative dielectrics for usage in the energy storage domain.
ETPTA Inverse Photonic Crystals for the Detection of Alcohols
Authors: Ashurov Matin , Kutrovskaya Stella , Baranchikov Alexander , Klimonsky Sergey , Kavokin Alexey
Published: August 2023

We developed a comparatively simple and inexpensive approach for the determination of the concentration of alcohols in water. The method is based on the study of the optical properties of ethoxylate trimethylolpropane triacrylate (ETPTA) inverse photonic crystals (IPhCs). The position of the transmission minimum associated with the first photonic stop band (PSB) is used as the analytical signal. The PSB position depends on the swelling degree of ETPTA photoresist and the refractive index of the tested alcohols and their mixtures with water. The signal increases linearly with increasing concentration of ethylene glycol and increases nonlinearly but monotonically with the concentration of methanol and ethanol in water. Sensitivity to alcohols, in the case of the ethylene glycol–water mixtures, reached about 0.55 nm/v.% or 560 nm/RIU (refractive index unit), which is sufficient for various applications in bio/chemical detection and environmental monitoring.
Effect of Ultrasonic Rolling on the Organization and Properties of a High-Speed Laser Cladding IN 718 Superalloy Coating
Authors: Hao Jingbin , Niu Qingwei , Ji Haowen , Liu Hao
Published: August 2023

To repair or improve the performance of H13 hot working molds through the additive manufacturing process, IN 718 was coated on H13 die steel by high-speed laser cladding followed by an ultrasonic surface rolling process (USRP). The mechanism of ultrasonic surface rolling on the mechanical properties of the coating was studied. After USRP, the coating exhibited severe plastic deformation; the microscopic organization of the surface layer was refined and the particle size was significantly reduced. The violent plastic deformation of the coating caused by USRP improved the dislocation density and the grain boundary density, providing an improved yield strength of the coating and improving the high-temperature wear resistance of the coating. After USRP, the surface hardness of the coating increased by 30%. Compared with the coating without USRP, the wear resistance of the coating greatly improved; the wear rate was reduced by 51% and the wear mechanism of the coating changed from large-area adhesive wear and severe abrasive wear to small-area adhesive wear and slight abrasive wear. The IN 718 coating after USRP had a higher hardness and greater wear resistance, significantly improving the service life of H13 steel.
Colored PDLC Films with Wide Gamut Range
Authors: Hu Yongchuan , Zhao Chenghu , Xu Jianjun , Yu Meina , Zou Cheng , Wang Qian , Gao Yanzi , Yang Huai
Published: August 2023

Due to the discoloration properties under different applied voltages, dye-doped polymer-dispersed liquid crystal (PDLC) films are widely used as camouflage nets and invisibility cloaks. However, the range of the discoloration has an intuitive effect on their applications. In this work, we studied the gamut range of PDLC film doped with dyes of red, green, blue, and yellow, with the concentration corresponding to the minimum haze of these dyes. The influence of the applied voltage on the color range of single-layer and double-layer films with different backgrounds was studied. The relationship of the voltage with the color was set from 0 V to 60 V at steps of 5 V, to characterize the discoloration of the PDLC films. The results showed that the films could cover 42.48% of the sRGB gamut and even exceed the range.
Salts of S-(+)-Ibuprofen Formed via Its Reaction with the Antifibrinolytic Agents Aminocaproic Acid and Tranexamic Acid: Synthesis and Characterization
Authors: Frösler Hannah M. , Ramulumo Humbelani S. , Edmonds-Smith Cesarina , Caira Mino R.
Published: August 2023

The paucity of multi-component compounds containing the non-steroidal anti-inflammatory drug (NSAID) S-(+)-ibuprofen (S-IBU) in combination with other drugs prompted the present study, which describes 1:1 salts of this active pharmaceutical ingredient (API) with the two most widely used antifibrinolytic APIs, namely 6-aminohexanoic acid (aminocaproic acid, ACA) and tranexamic acid (TXA), which are zwitterions in the solid state. Since NSAIDs are known to cause adverse side effects such as gastrointestinal ulceration, the presence of ACA and TXA in the salts with S-(+)-ibuprofen might counter these effects via their ability to prevent excessive bleeding. The salts were prepared by both the liquid-assisted grinding method and co-precipitation and were characterized by X-ray powder diffraction and single-crystal X-ray diffraction, thermal analysis, Fourier transform infrared spectroscopy, and solubility measurements. The X-ray analyses revealed a high degree of isostructurality, both at the level of their respective asymmetric units and in their extended crystal structures, with charge-assisted hydrogen bonds of the type N-H+⋅⋅⋅O− and O-H+⋅⋅⋅O− featuring prominently. The thermal analysis indicated that both salts had significantly higher thermal stability than S-(+)-ibuprofen. Solubility measurements in a simulated biological medium showed insignificant changes in the solubility of S-(+)-ibuprofen when tested in the form of the salts (S-IBU)−(ACA)+ and (S-IBU)−(TXA)+.
The Analysis of Changes in the Crystal Structure of Near-Beta Titanium Alloy in the Solution-Treated and Aged Conditions after Static Tensile Testing
Authors: Krawczyk Janusz , Frocisz Łukasz , Goły Marcin , Tomasik Sylwia , Śleboda Tomasz
Published: August 2023

Titanium alloys are characterized by insufficient ductility. One of the parameters affecting their ductility is their crystal structure and texture. The present study characterizes the changes in the crystallographic texture of the Ti-3Al-8V-6Cr-4Zr-4Mo alloy in solution-treated and aged conditions on the basis of texture intensity indices and pole figures. Analysis of crystal structure changes was performed before and after tensile testing. The investigated alloy in the solution-treated condition showed a single-phase β-solution structure with a body-centered cubic (BCC) crystal structure. The process of β phase aging affected the result of the tensile test, affecting the parameters of the texture of the β phase. The analysis of the texture intensity indices for each set of planes (hkl) related to the intensity for the plane (110) indicated that the highest texture intensity occurs for β titanium alloy aged at 550 °C both before and after tensile test. After plastic deformation, the largest difference with respect to the benchmark value was observed for the (220) and (310) planes. The least amount of texture intensity occurred after aging at 450 °C. The most varied values of diffraction peak intensity in relation to the benchmark were obtained for the alloy aged at 450 °C for the (310), and (200) and (211) planes, indicating the dominance of the (211) orientation, where an elongation of 10.4% was achieved. For the highest elongation of 14.2%, achieved for the sample solution-treated at 550 °C, the diffraction peak intensities were intermediate with the dominance of peaks from the planes (200) and (310).
Responses of GPS-Tagged Territorial Golden Eagles Aquila chrysaetos to Wind Turbines in Scotland
Authors: Fielding Alan H. , Anderson David , Benn Stuart , Taylor John , Tingay Ruth , Weston Ewan D. , Whitfield D. Philip
Published: August 2023

Research on potentially adverse effects of wind farms is an expanding field of study and often focuses on large raptors, such as golden eagles, largely because of their life history traits and extensive habitat requirements. These features render them sensitive to either fatality (collision with turbine blades) or functional habitat loss (avoidance through wariness of turbines). Simplistically, avoidance is antagonistic to collision; although, the two processes are not necessarily mutually exclusive in risk. A bird that does not enter a wind farm or avoids flying close to turbines cannot collide with a blade and be killed. In the USA, collision fatality is implicated as the typical adverse effect. In Scotland, avoidance of functional habitat loss appears more likely, but this depends in part on the habitat suitability of turbine locations. Previous Scottish studies have largely concentrated on the responses of GPS-tagged non-territorial golden eagles during dispersal. Several arguments predict that territorial eagles may have lower avoidance (be less wary) of turbines than non-territorial birds. Hence, we contrasted the responses of GPS-tagged non-territorial (intruding) and territorial eagles to the same turbines at 11 operational Scottish wind farms. We show that territorial eagles rarely approached turbines, but, as in previous Scottish studies of non-territorial birds, the spatial extent of avoidance depended on the habitat suitability of both turbine locations and their wider surroundings. Unexpectedly, we found that territorial eagles were apparently as wary as intruding non-territorial conspecifics of the same turbines. Our results show that regardless of age or territorial status, Scottish golden eagles largely avoided wind turbine locations, but this avoidance was conditional, in part, on where those turbines were located. Responses to turbines were also strongly dependent on birds’ identities and different wind farms. We speculate on how widespread our findings of avoidance of turbines by golden eagles are elsewhere in Europe, where there appear to be no published studies showing the level of collision fatalities documented in the USA.
Automatic Detection and Classification of Diabetic Retinopathy Using the Improved Pooling Function in the Convolution Neural Network
Authors: Bhimavarapu Usharani , Chintalapudi Nalini , Battineni Gopi
Published: August 2023

Diabetic retinopathy (DR) is an eye disease associated with diabetes that can lead to blindness. Early diagnosis is critical to ensure that patients with diabetes are not affected by blindness. Deep learning plays an important role in diagnosing diabetes, reducing the human effort to diagnose and classify diabetic and non-diabetic patients. The main objective of this study was to provide an improved convolution neural network (CNN) model for automatic DR diagnosis from fundus images. The pooling function increases the receptive field of convolution kernels over layers. It reduces computational complexity and memory requirements because it reduces the resolution of feature maps while preserving the essential characteristics required for subsequent layer processing. In this study, an improved pooling function combined with an activation function in the ResNet-50 model was applied to the retina images in autonomous lesion detection with reduced loss and processing time. The improved ResNet-50 model was trained and tested over the two datasets (i.e., APTOS and Kaggle). The proposed model achieved an accuracy of 98.32% for APTOS and 98.71% for Kaggle datasets. It is proven that the proposed model has produced greater accuracy when compared to their state-of-the-art work in diagnosing DR with retinal fundus images.
Optical Coherence Tomography Angiography Is a Useful Tool for Distinguishing Primary Raynaud’s Phenomenon from Systemic Sclerosis and/or Very Early Disease of Systemic Sclerosis
Authors: Erturk Adem , Erogul Ozgur , Kasikci Murat
Published: August 2023

This cross-sectional study aimed to compare optical coherence tomography angiography (OCT-A) findings in patients with primary Raynaud’s phenomenon (PRP; n = 22), very early disease of systemic sclerosis (VEDOSS; n = 19), and systemic sclerosis (SSc; 25 patients with limited cutaneous SSc (lcSSc) and 13 patients with diffuse cutaneous SSc (dcSSc)). Whole, parafoveal, and perifoveal superficial capillary plexus (SCP) vessel densities (VDs), deep capillary plexus VDs, and whole, inside, and peripapillary VDs were significantly higher in the PRP group (p < 0.001). In the lcSSc group, the FAZ perimeter was significantly higher than that in the VEDOSS group (p = 0.017). Retinal nerve fiber layer VDs were significantly lower in the lcSSc group than in the PRP and VEDOSS groups (p < 0.001). The whole and peripapillary optic disc VDs of the VEDOSS group were significantly higher than in the lcSSc group (p < 0.001). Whole SCP VDs (94.74% sensitivity, 100.00% specificity) and parafoveal SCP VDs (89.47% sensitivity, 100.00% specificity) showed the best performance in distinguishing patients with SSc from those with PRP. OCT-A seems to have potential diagnostic value in differentiating patients with PRP from patients with SSc and VEDOSS, and there is potential value in assessing prognostic roles, since findings from OCT-A images could be early indicators of retinal vascular injury long before overt SSc symptoms develop.
Diagnostic Value of Four-Dimensional Dynamic Computed Tomography for Primary Hyperparathyroidism in Patients with Low Baseline Parathyroid Hormone Levels
Authors: Al-Difaie Zaid , Scheepers Max H. M. C. , Engelen Sanne M. E. , Havekes Bastiaan , Bouvy Nicole D. , Postma Alida A.
Published: August 2023

Low baseline levels of parathyroid hormone (PTH) are associated with a higher rate of multiglandular disease, lower localization rates of preoperative imaging modalities, and a higher rate of unsuccessful minimally invasive parathyroidectomies. The objective of this study is to assess the diagnostic value of four-dimensional dynamic computed tomography (4D-CT) in localizing primary hyperparathyroidism (pHPT) in patients with low baseline PTH levels, compared to patients with high baseline PTH levels. Patients with pHPT who received a 4D-CT scan as part of their standard diagnostic evaluation were divided into two groups based on the following criteria: (1) preoperative PTH levels less than 100 pg/mL and (2) patients with preoperative PTH levels greater than 100 pg/mL. All patients underwent parathyroidectomy based on 4D-CT findings, with intraoperative parathyroid hormone monitoring. The lesion-based sensitivity of 4D-CT was 88% in patients with low baseline PTH levels and 94.7% in patients with high baseline PTH levels (p = 0.33). However, the success rate of image-guided resection based on 4D-CT findings was 71.4% in the low baseline PTH group compared to 90.6% in the high baseline PTH group (p = 0.06). Our study demonstrated that 4D-CT has a high lesion-based sensitivity in patients with pHPT and low baseline PTH levels but led to a relatively low rate of successful image-guided resection in patients with low baseline PTH levels. Therefore, it is important to exercise increased caution during 4D-CT-guided surgical exploration of patients with low baseline PTH levels to ensure successful surgical resection of all parathyroid lesions.
The Effects of Vitamin D Supplementation on Respiratory Infections in Children under 6 Years Old: A Systematic Review
Authors: Marusca Larisa Mihaela , Reddy Gowry , Blaj Mihaela , Prathipati Reshmanth , Rosca Ovidiu , Bratosin Felix , Bogdan Iulia , Horhat Razvan Mihai , Tapos Gabriela-Florentina , Marti Daniela-Teodora , Susan Monica , Pingilati Raja Akshay , Horhat Florin George , Adelina Mavrea
Published: August 2023

Childhood respiratory tract infections (RTIs) pose a significant health burden, especially in children under six years old. The main objective of this systematic review was to assess the effectiveness of vitamin D supplementation in the prevention of RTI in this population while also exploring potential effect modifiers such as age, baseline vitamin D status, and type of respiratory infection. A systematic review of the literature published up to February 2023 was conducted according to PRISMA guidelines, searching PubMed, Web of Science, Cochrane, and Scopus databases. Eight studies met the inclusion criteria, which investigated the association between vitamin D supplementation and respiratory infections in children between zero and five years old. The included studies were conducted between 2012 and 2021, encompassing a total of 2189 children from five randomized trials, two case-control studies, and one prospective cohort study. The relationship between vitamin D supplementation and the prevention of childhood RTI was not consistently observed across all included studies. Pooled results demonstrated varied effects of vitamin D supplementation on respiratory infection incidence, severity, and symptoms. Three studies reported statistically significant associations between low vitamin D levels and respiratory infections (OR = 4.90, OR = 6.97), while one study found that children who received vitamin D supplementation of 800 UI/day for 3 months during the cold season had fewer episodes of respiratory symptoms (RR = 0.55) and recovered more quickly from acute RTI. Lastly, according to one study, vitamin D intake < 80 IU/kg/day was significantly associated with the risk of acquiring pneumonia (OR 7.9) but not bronchiolitis. The remaining five studies found no statistically significant differences in infection rates or severity (p-value > 0.050). The available evidence on the effectiveness of vitamin D supplementation for preventing and treating respiratory infections in children under six years old is limited, with only a few favorable effects being reported. In some cases, a dose of 80 UI/kg/day was found to provide significant protection for acute respiratory infections, although in the major trials the only benefit was a quicker recovery and fewer respiratory symptoms, with no impact on incidence and severity of respiratory infections. Nevertheless, the study protocol, the supplementation dose, and duration of supplementation had significant variations between studies, leading to inconclusive findings.
Three-Dimensional Analysis of Upper and Lower Arches Using Digital Technology: Measurement of the Index of Bolton and Correspondence between Arch Shapesand Orthodontic Arches
Authors: Pasini Marco , Carli Elisabetta , Giambastiani Federico , Giuca Maria Rita , Tripodi Domenico
Published: August 2023

Introduction: Thanks to the great development of digital technology, viaCAD (computer-aided design) and CAM (computer-aided manufacturing) systems, digital models canbe used as an aid for orthodontic planning decision-making processes as there are numerous studies in the literature that support the validity ofthe digital model measurements of anterior teeth and the total coefficient of Bolton analysis. The aim of the present study isto compare the average length value of the current upper and lower arches with that of a hypothetical nickel–titanium wire and to confirm the reliability and accuracy of digitally taken measurements of the anterior and total Bolton coefficients.In this retrospective study, dental casts of 138 Caucasian adolescent patients were scanned with an extraoral scanner, and Ortho3Shape software was adopted for the following dental cast measurements: actual and ideal lengths of the lower arches and anterior and total Bolton coefficients.In the present study, we found that the mean value of the anterior coefficients of the Bolton index was compatible with those of previous studies, confirming the reliability of digital measurements.Therefore, digital CAD/CAM models may be a viable alternative to plaster models, as they can facilitate model preservation and recovery. For future studies, it would be better to use intraoral scanners (IOSs) to ensure greater accuracy, since they only require one step and allow obtaining better results for the patients.
Evaluation of Almond Harvest Dust Abatement Strategies Using an Aerial Drone Particle Monitoring System
Authors: Baticados El Jirie N. , Capareda Sergio C.
Published: August 2023

This study demonstrates the feasibility of a mobile aerial drone particle monitoring system (DPMS) to measure and detect changes in harvest dust levels based on moderate adjustments to harvester settings. When compared to an earlier harvester, a new harvester operated at standard settings produced 35% fewer PM2.5s, 32% fewer PM10s, and 42% fewer TSPs. Increasing the ground speed had an adverse effect on dust mitigation, while reducing it by half only offered a slightly more favorable margin. The mutual effects of some meteorological factors were found to be slightly correlated with PM10 and TSP readings and caused significant variability in PM2.5 readings. The current findings show similar trends to PM reduction estimates of previous studies, with only a nominal difference of 10 to 15% points. Overall, the DPMS was found to perform well within an acceptable statistical confidence level. The use of DPMSs could reduce the logistical needs, complexity issues, and feedback times often experienced using the Federal Reference Method (FRM). Further investigation is needed to verify its robustness and to develop potential correlations with the FRM under different orchard location and management practices. At this stage, the current aerial DPMS should be considered a rapid screening tool not to replace the FRM, but rather to complement it in evaluating the feasibility of dust abatement strategies for the almond industry.
Spatial Modeling of Air Pollution Using Data Fusion
Authors: Dudek Adrian , Baranowski Jerzy
Published: August 2023

Air pollution is a widespread issue. One approach to predicting air pollution levels in specific locations is through the development of mathematical models. Spatial models are one such category, and they can be optimized using calculation methods like the INLA (integrated nested Laplace approximation) package. It streamlines the complex computational process by combining the Laplace approximation and numerical integration to approximate the model and provides a computationally efficient alternative to traditional MCMC (Markov chain Monte Carlo) methods for Bayesian inference in complex hierarchical models. Another crucial aspect is obtaining data for this type of problem. Relying only on official or professional monitoring stations can pose challenges, so it is advisable to employ data fusion techniques and integrate data from various sensors, including amateur ones. Moreover, when modeling spatial air pollution, careful consideration should be given to factors such as the range of impact and potential obstacles that may affect a pollutant’s dispersion. This study showcases the utilization of INLA spatial modeling and data fusion to address multiple problems, such as pollution in industrial facilities and urban areas. The results show promise for resolving such problems with the proposed algorithms.
Experimental Study on Wind Turbine Airfoil Trailing Edge Noise Reduction Using Wavy Leading Edges
Authors: Xing Yudi , Wang Xingyu , Chen Weijie , Tong Fan , Qiao Weiyang
Published: August 2023

Aerodynamic noise produced by the rotating blade is an important hindrance for the rapid development of modern wind turbines. Among the various noise sources, the airfoil trailing edge noise contributes a lot to the wind turbine noise. The control of wind turbine airfoil trailing edge self-noise by bio-inspired sinusoidal wavy leading edges is experimentally studied in a semi-anechoic chamber. The noise radiated by the baseline NACA 0012 airfoil and various wavy airfoils is measured using a planar microphone array consisting of fifty-two microphones. The noise source identifications are achieved by using the CLEAN-SC method. The effects of velocity and angle of attack on noise radiation of the baseline airfoil are analyzed in detail. The noise control law of the wavy amplitude and wavelength on airfoil trailing edge noise is explored. Based on the acoustic beamforming results, the noise control effects of the wavy leading edges are intuitively demonstrated. In general, the wavy leading edge with a larger amplitude and smaller wavelength has a better effect on the airfoil trailing edge noise reduction. The maximum sound pressure level reduction can be up to 33.9 dB. The results of this study are expected to provide important information for wind turbine aerodynamic noise control.