bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Mobility Patterns to Oklahoma Food Banks During the SARS-COV-2 Pandemic
Authors: Swayne Madison R. E. , Lowery Bryce C. , Reeves Halley , Dundas Nicole
Published: June 2023

We investigate changes in travel to food banks during the outbreak of SARS-CoV-2. The pandemic created challenges that impacted the availability of food and the ability of individuals to access food – increasing demand on food banks. In a context where face-to-face interactions were not possible, we use cell phone mobility data to evaluate changes in food bank utilization during this period of increased demand for services. From 2017 to 2019 there were an increasing number of trips to food banks from a closer set of census block groups. In 2020 overall trips decreased but travel distances to food banks increased.
Problematika Guru dalam Penerapan Media Pembelajaran Inovatif pada Pembelajaran Seni Budaya dan Prakarya
Authors: Rohmatillah Renzy Ayu
Published: June 2023

The role of learning media is very important in order to maximize the delivery of learning material to students. Learning media that are interesting and in accordance with learning materials will be able to attract student learning interest and knowledge can be conveyed better. This research was conducted to explore the use of innovative learning media in learning arts and culture and skills in SDN 1 Jatiprahu. The method that applied is qualitative research method and use case study approach. According to the research results from interviews and observations, it was found that there were several teacher problems in implementing innovative learning media in schools, namely the media applied to project-based learning models were still not diverse, teachers had difficulties in preparing learning media, facilities at schools were inadequate still minimal, and the government does not support learning innovations in schools.
Construction of Women in Religious Relations and Social Change on the Indonesia-Singapore Border, Batam City, Riau Islands
Authors: Solina Emmy , Niko Nikodemus , Elsera Marisa
Published: June 2023

This study explores the construction of women in religious relations and their role in social change on the Indonesia-Singapore border, specifically focusing on Batam City in the Riau Islands. The religious landscape of this region is diverse, with various religious practices and beliefs coexisting. Understanding the dynamics of gender within these religious contexts is crucial to comprehending how women navigate and contribute to social change. The research employs a qualitative approach, such as observation, interviews, and document analysis. By engaging with local communities, religious leaders, and women themselves, this study seeks to uncover the multifaceted roles women play within religious institutions and the broader society. The findings shed light on the ways in which women negotiate their religious identities, practices, and responsibilities, as well as the challenges they encounter in their pursuit of social change. The study also examines the impact of globalization and transnational connections on the construction of women's religious roles, exploring how women in Batam City are influenced by and respond to global trends and ideas. Furthermore, the research addresses the power dynamics at play within religious institutions and how they shape women's experiences and opportunities for social transformation. It investigates the agency exercised by women in religious leadership roles and grassroots initiatives, highlighting the strategies they employ to challenge existing gender norms and advocate for gender equality.
An Investigation of Pre-Service English Teachers' Proficiency in Basic Teaching Skills During Classroom Practice
Authors: Husain Nurlaila , Pilongo Jolanda Hulda Debora , Palaji Viranda
Published: June 2023

English teachers need basic teaching skills. This study examines how seven pre-service English teachers employ the eight core teaching skills. A qualitative study analyzed learning records from teaching practice assessments to explore how pre-service English teachers utilized these skills. It identified eight basic teaching techniques with varying levels of proficiency. First, explanation (93.88%), variation (92.06%), and small group and individual instruction (92.86%). Second, good skills include opening and closing lessons (75.51%), questioning (67.86%), and classroom management (78.57%). Finally, skills reinforcement (61.9%) and leading small group discussions (63.27%) are sufficient. The study indicates some pre-service English teachers need basic skills training.
Development of ideas about the mechanism of coal-overlaying formation displacement in terms of its influence on local gas-drainage parameters in the Western Donbas conditions
Authors: Bondarenko V , Salieiev I , Kovalevska I , Symanovych H , Shyshov M , Malova O
Published: June 2023

Purpose. The research purpose is to study the mechanism of the influence of geomechanical-technological factors on the location parameters of the gas-drainage wells behind the longwall face in the area of stope operations under the conditions of weakly metamorphosed rocks. Research methodology. An integrated approach is used, including an analysis of existing research on the gas release patterns in the mine workings of extraction sites and local gas-drainage parameters, analysis of geomechanical processes, development of schemes for modeling by the finite element method, substantiation of methodological approaches for conducting experimental research into the rock pressure manifestations in extraction working, taking into account existing tendencies of the influence of stoping face advance velocity. Research results. The views on the mechanism of the stratified mass texture transformations of weak rocks have been developed during the study of the optimal extraction site gas-drainage parameters. The deformation development schemes have been constructed for any layer of the main roof behind the area of longwall face conjugation with the extraction working, displacement of coal-overlaying formation rocks along and across the extraction site with the location of gas-drainage wells. Based on the conducted research, recommendations on the rational location of gas-drainage wells have been obtained. Scientific novelty. The main characteristics of the weakly metamorphosed rock displacement process in the area of stope operations are studied in a spatial formulation, and the mechanism of the influence of geomechanical-technological factors on the expedient location parameters of gas-drainage wells behind the longwall face is represented on the relevant schemes. Practical value. The reliability of the proposed location parameters for gas-drainage wells behind the longwall face in the conditions of weakly metamorphosed rocks of the Western Donbas has been analyzed, taking into account the stoping face advance increased velocities.The conclusions drawn on the basis of rock displacement tendencies in the coal-overlaying formation are summarized in the schemes for identifying the mechanism of rock mass deformation near the area of stope operations.
Analysis of the use of composite materials for further application in the support of mine workings
Authors: Sheka I , Salieiev I , Shyshov M , Malova O , Pochepov V , Mamaikin O
Published: June 2023

Purpose. To analyze composite materials and prospects of their use for roof support in coal mines. Research methodology. To achieve this purpose, we used analytical data on the market of composite materials, the volume of their production capacity, and cost indicators. Data on the physical and mechanical properties of composite materials and their quantitative indicators were used. Research results. The areas of application of composite materials in industry are analyzed and summarized. The analysis shows that composite materials are used in many areas of industry: medicine, construction, defense, etc. A comparative analysis of the physical and mechanical properties of carbon fiber-reinforced plasticand steel shows that this composite material has identical (and sometimes even better) properties than metal materials. The study concluded that it is better to use carbon fiber as a support material for mine workings in coal mines. The advantages and disadvantages of carbon fiber-reinforced plasticas a roofing material for coal mine workings are evaluated. It is clarified that the current limiting factor is the cost of carbon fiber-reinforced plastic, but over time, their price will decrease and their demand will increase. It is concluded that the use of this composite material in the elements of mine support can increase the pace of their implementation, reduce the labor intensity of the work performed and improve the working conditions of miners while lightening the structure. Scientific novelty. The physical and mechanical properties of composite materials have been analytically determined and it has been substantiated that carbon fiber-reinforced plasticsupports can be used in the support of preparatory workings in coal mines. Practical value. The obtained results prove that the support made of carbon fiber-reinforced plasticwill facilitate the design of the support, which, together with the acceleration of the shift operation, will contribute to the development of underground coal mining.
Identification of objects based on the data of tenzometrical systems with using methods of machine learning
Authors: Kolysnychenko I , Tkachov V
Published: June 2023

Objective. To increase the quality of work of tensometric systems, using data obtained from the strain gauge system in the form of maps of the passage of moving objects, it is necessary to conduct research on the data of the strain gauge system and develop a set of algorithms, thanks to which it is possible to obtain the characteristics of railway cars in rolling stock and carry out identification of railway objects objects with a minimum error for further use of the obtained results in the construction of a system of identification and weighing of moving objects through tensometric systems. Research methods. To build a system for identifying different types of moving objects through single-platform railway scales in motion, it is proposed to use machine learning methods, namely neural networks and clustering algorithms. The software implemented as part of scientific research is written in the Python programming language using numPy, sklearn, statistics, and other libraries. Findings. Using such methods of machine learning as convolutional neural networks, clustering, perceptron and relying on the reference data of railway objects that can be used on the territory of Ukraine, a number of algorithmic solutions were obtained and implemented in the form of software, which identify the type of car by such characteristics such as the axle of the cart, the axle of the wagon, the ratio of the base of the wagon to the length of the wagon between the couplings, the weight of the axles. Using the weight coefitient for a specific tensometric system, during the calibration of the scales, the dependence of the weight of the car on its type and the mass of each of the axles was obtained. The originality. After conducting a study of the data on the passage of railway carriages and auto couplings through single-platform scales, it was established that the types of wagons can be categorized by such characteristics as the ratio of the base of the wagon to the length of the wagon between the auto couplings, the axle, weight. To obtain the ratio of the wagon base to the length of the wagon between autocouplings, it is necessary to perform data segmentation and clustering as follows - the wagon base is found as the distance between the middle of two bogies, and the length of the wagon between autocouplings as the middle of the distance between the bogies to the middle of the autocoupling. Practical implications. Using such methods of machine learning as convolutional neural networks, clustering, perceptron and others, an algorithmic solution for data processing of strain gauge systems was obtained, which allows to increase the accuracy of the identification of wagons, while reducing the dependence of the results on the speed of the wagons, which allows to increase the capacity of weighing systems of enterprises
Determination of the model of a powered air-purifying respirator for researching its operational modes
Authors: Slavynskyi D
Published: June 2023

Purpose. Justification of technical decisions when creating an experimental equipment of a powered air-purifying respirator (PAPR), development of a research system, planning and conducting an experiment, determining the structure of the object and its parameters, confirming the adequacy of the obtained simulation model of the PAPR to the control object in accordance with the conditions of the technological process. Methodology. The research was carried out on experimental equipment by means of an active experiment. It is proposed to use a sensor with an analog output and a controller for data registration to control the pressure. By varying the rotation speed of the fan, the value of the pressure in the respirator mask was determined. Structural and parametric identification and verification of the obtained model for adequacy to the control object according to the Fisher criterion were carried out on the basis of the obtained data. Findings. Based on the results of the study, it was established that the PAPR is an asymmetric object according to the "fan rotation speed - pressure in the mask" channel. The processes of pressure increase and decrease correspond in form to exponential functions and can be described by aperiodic links of the first order with different time constants. Based on the analysis of the structure of the control object, a corresponding asymmetric model was created in which aperiodic links are represented in the state space. Theprocess time constants and amplification factor of the model were determined by parameter estimation. The adequacy of the obtained simulation model to the control object was confirmed by Fisher's criterion. Originality. For the first time, a continuous transfer function of a PAPR was obtained in the form of a complex of two firstorder aperiodic links with different time constants. Practical value. A universal method of obtaining simulated models of PAPRs by using the developed experimental equipment and simulation environment of the MATLAB. The obtained simulation model of the PAPR allows to research its operating modes in order to determine the requirements for the control system and its further synthesis using various regulators.
An interesting case of Posterior Layering in the Urinary bladder on Fluorine- 18 Fluorodeoxyglucose (F18-FDG) PET-CT study
Authors: Farhana Sharmin , Sifat Taslima , Mia Shohag , Quddus Ruhul , Khan Biva S , Islam Saiful , Hussain Raihan , Kabir MF
Published: June 2023

Contrast PET/CT may show layering within the UB, and several examples of have been reported in the literature. But without using contrast this is rare. Our case demonstrates the interesting posterior layering of F18-FDG in urinary bladder in a 78 years old male without the use of contrast.

Pulse Volume 12-14 2020-2022 p.32-33
Case series report of LINAC-based Stereotactic radiosurgery of Intracranial meningioma – an institutional experience
Authors: Yasmin Taohida , Kumar Narendra , Appasamy Murugan , Ahsan Sania , Rana KM Masud , Kumar R Arun , Joarder Aliuzzaman , Rahman Zillur , Bhattacharjee Biswajit , Afrin Taslima , Chowdhury Arman Reza
Published: June 2023

Stereotactic radiosurgery (SRS) has been widely used for the treatment of intracranial lesions. We have been doing SRS since March 2019. The unique ability of SRS to deliver higher focused dose to the smaller targets preferably in a single exposure in a convenient manner while sparing adjacent critical structures has made a more widely adopted treatment option. This case series is intended to show our institutional experience and procedural technique adapted for treating intracranial meningioma using SRS by Linear accelerators. We present five cases of intracranial meningioma. Four had Grade I meningioma and one patient with Grade III meningioma. One patient had radiological diagnosis only and treated with SRS. Two patients underwent gross total resection and SRS was prescribed on the event of recurrence. Rest two patients had recurrence/progression after subtotal resection and adjuvant radiation. The dose prescription ranged from 13 to 21Gy in one to three fractions which was determined by tumor volume, location, grade, proximity to critical structures, pre-existing neurologic impairment, previous treatment history, time to progression/relapse and the ideal balance of prescription dosage and expected problems. There were no acute side effects from any of the procedures. All five patients had improvement in clinical symptoms in the immediate post-SRS period. One patient who has two-year post-SRS revealed a significant regression in the size of the tumor. This case series summarizes the fact that SRS for intracranial meningioma is safe and effective treatment strategy when appropriate.

Pulse Volume 12-14 2020-2022 p.40-52
Empirical Analysis of Emigration to Europe from Türkiye: Evidence from the Gravity Model Including the Covid-19 Effect for the Period 2015-2021
Authors: BAYLAN Mustafa , ÇELİK Onur
Published: June 2023

Bu çalışma ile uluslararası göç, gelir, nüfus ve mesafe değişkenleri arasındaki ilişki, Covid-19 pandemi sınırlamalarını içeren çekim modeli kapsamında ele alınmaktadır. Covid-19 etkisinin modelde yeri alması, bilimsel literatür için bir yeniliği ve bu çalışmanın ilgili alana katkısını oluşturmaktadır. Türkiye’den, Türk göçmenlerin en çok tercih ettiği 10 Avrupa ülkesine göç hareketleri 2015-2021 dönemi için statik panel veri analizi ile araştırılmaktadır. GLS regresyon analizinden elde ettiğimiz sonuçlar belirtiyor ki; göç veren ülkedeki gelir düzeyi ve Covid-19 sınırlamaları göçü azaltırken, göç alan ülkedeki gelir düzeyi göçü artırmaktadır. Ayrıca, insanlar daha kalabalık bölgelere göç etme eğilimindedir. Varış bölgesindeki nüfus, göç hareketlerinin pozitif bir fonksiyonudur. Son olarak, mesafe faktörü ve göç veren ülkedeki nüfus, göç üzerinde anlamlı bir etki göstermemektedir. Salgın etkisini içeren çekim modelindeki açıklayıcı değişkenler, göç hareketlerindeki değişimin yaklaşık olarak %79’unu açıklamaktadır. Elde ettiğimiz sonuçlar doğrultusunda, oluşturulan göç politikalarının olası beyin göçünü dikkate alması önerilmektedir.
Engaging Preschoolers in STEAM Education: An Adaptation of a Nano-Literacy Program in Distance Education
Authors: Vretudaki Hellen , Klada Evangelia
Published: June 2023

The aim of this paper is to present a program in nanoscience and nanotechnology (NST) to pre-school children through distance education. The activities followed the teaching learning sequence (TLS) methodology and dealt with: a) the nano scale and size, b) exposing children to appropriate instruments/tools through which they investigated elements of the nanoworld and c) raising pre-school children’s awareness of applications of nanotechnology, based on the interdisciplinary STEAM approach. For this reason, a series of organized activities which had been implemented at an earlier time in a kindergarten setting were redesigned to meet the current needs of the children in the context of distance learning during the pandemic lockdown. The results from the implementation of the learning sequence were very encouraging in terms of the perceptual and exploratory abilities of the preschool children. By the end of the program, the children were able to identify "nano" size materials. In addition, they seemed to be able to reflect on the application of nanotechnology in their daily lives.
Scalp cooling and chemotherapy: evaluation of quality of life and trichoscopy
Authors: Silva Poliana Rodrigues , Bordignon Cláudia , Lorenzini Fabiane , Caramori Ana Paula Avancini , Brundo Sabrina Terezinha de Souza Gilli , Osorio Ariane Pereira , Rosa Daniela Dornelles
Published: June 2023

Objectives: This study aimed to evaluate the quality of life (QoL) of patients undergoing scalp cooling during chemotherapy and to describe hair density data assessed by trichoscopy. Background: Hair loss during chemotherapy is a common and distressing side effect, and prevention can be done through scalp hypothermia. Methods: A prospective cohort study was conducted at a single oncology center in Brazil. Patients undergoing scalp cooling during chemotherapy were included. QoL and body image satisfaction (BIS) questionnaires were administered at the beginning and end of treatment. Data on alopecia were collected. Trichoscopy with a Fotofinder® device was performed at the beginning, before the second cycle, and at the end of treatment. STROBE guidelines were followed for the development of this study. Results: Twenty-seven patients were included. There was no difference in mean QoL or BIS scores in the comparison of patients with hair loss < 50% with those with hair loss ≥ 50%. Better outcomes in the QoL and BIS scales were found in patients treated with anthracyclines. Hair density described by trichoscopy showed a maximum reduction of up to 16.3%, and loss was more common in the frontal area. Conclusions: Thus, there is no clear evidence of better QoL in patients with a lower grade of alopecia after scalp cooling during chemotherapy. Validated scales can be useful for assessing QoL in this population.
Pseudomonas fluorescens, inoculada via sementes, promove crescimento e aumenta a disponibilidade de fósforo na cultura do milho
Authors: Guimarães Vandeir Francisco , Klein Jeferson
Published: June 2023

Este estudo visa avaliar a eficiência a campo de Pseudomonas fluorescens, inoculada na semente, em promover crescimento e disponibilizar fósforo, para o milho. Conduziu-se ensaios de outubro de 2018 a março de 2019, em Toledo, Palotina, São Miguel do Iguaçu e Santa Tereza do Oeste, no Paraná em blocos casualizados, com quatro repetições. T1- Controle; T2- 50% de P, sem inoculação; T3- 100% de P, sem inoculação; T4- 50% de P e inoculação das sementes com P. fluorescens (50 mL/60.000 sementes); T5- 50% de P e inoculação das sementes com P. fluorescens (100 mL/60.000 sementes); T6- 50% de P e inoculação das sementes com P. fluorescens (150 mL/60.000 sementes); e T7- 50% de P e inoculação das sementes com P. fluorescens (200 mL/60.000 sementes). Avaliou-se teores de N, P e K em folhas e grãos, componentes da produção e produtividade. Concluiu-se que a inoculação de sementes de milho com P. fluorescens, com 100 mL/60.000 sementes e 50% P, foi eficiente em promover crescimento no milho, mantendo ou elevando a produtividade, quando comparado à dose total de P.
Influência do HIV e do tabagismo na mortalidade de pacientes diagnosticados com tuberculose no estado do Paraná
Authors: Gouveia Nathalia Carelli , Lourenço Gabriel Henrique , Santos Renan Marques dos
Published: June 2023

Tuberculose (TB) é a infecção oportunista mais importante entre pessoas vivendo com o Vírus da Imunodeficiência Humana (HIV). Sendo esse um fator de risco para desfechos terapêuticos negativos na TB e para maior mortalidade. Já o tabagismo, aumenta a suscetibilidade à infecção latente de TB, progressão à doença ativa, atraso na negativação do exame de escarro, falhas de adesão ao tratamento, recaída e multirresistência. Somando-se a isso, quando associado ao HIV, o tabagismo aumenta o risco de pneumonia e de doenças da orofaringe, além de elevar o risco para doenças cardiovasculares, dislipidemia, resistência insulínica e doença pulmonar obstrutiva crônica. Esse estudo é uma pesquisa quantitativa entre pacientes com diagnóstico de tuberculose, HIV positivos e tabagistas, diagnosticados no estado do Paraná. Objetivou-se mensurar o impacto do tabagismo e do HIV na mortalidade de pacientes diagnosticados com tuberculose, utilizando como instrumento de pesquisa a base de dados do Sistema de Informação de Agravos de Notificação (SINAN), por meio do Departamento de Informática do Sistema Único de Saúde (DATASUS). Ao final do estudo encontrou-se que o tabagismo não foi determinante para aumento da mortalidade, enquanto a presença da sorologia positiva para HIV aumenta significativamente as taxas de mortalidade dos pacientes com tuberculose.
Prognostic and treatment effect modeling in medical research
Authors:   , Hoogland Jeroen
Published: June 2023

Prediction models are increasingly used in the medical domain, benefitting from the increased availability of digital healthcare data and accessible software implementations. Two important applications of such models are (i) predicting the likely course of a medical condition (also known as prognosis) and (ii) predicting of the consequences of a particular treatment decision. In both cases, the goal is often to go beyond the prediction of population averages towards more personalized predictions. This dissertation provides a biostatistical perspective on such prediction models for prognosis and treatment effects.

Specific methodological contributions include methods to handle missing data points during the validation of prediction models and their application in practice. New developments are also described regarding methods that help strike the right balance between model complexity and the size of the available data. Furthermore, the differences between associative and causal prediction modeling are explored in depth, and guidance is provided for the development of prediction models for predicting personalized treatment effects based on randomized trial data. models for treatment effect heterogeneity based on randomized trial data is provided. Subsequently, the evaluation of the quality of such models is described, including a novel approach to measure prediction performance. Finally, an applied chapter describes the modeling of both prognosis and treatment effect in a context where individual patient level data are available from multiple studies.
Building bridges: precision medicine in pediatric oncology
Authors:   , Langenberg-Ververgaert Karin Petra Sabine
Published: June 2023

Childhood cancer is the leading cause of death in children and young adults in developed countries. To improve outcomes and minimize side effects, the field of “precision medicine” is being explored, aiming to select treatments based on unique characteristics of cancer cells. Large-scale studies analyzing DNA and RNA traits of pediatric cancer have shown major differences between cancers in children and adults. Over 50% of tumors have shown alterations that might make them sensitive to specific drugs. However, efficacy of targeted treatments remains challenging to predict. Therefore, novel functional methods including drug sensitivity testing on tumor derived cells (“organoids”) are investigated to complement aforementioned approaches.

In this thesis, we summarize advancements in precision medicine in pediatric oncology. We present results of the Dutch precision-oncology program "iTHER", which analyzed over 300 samples of pediatric tumors and found alterations to support treatment with specific medicines. While the study produced promising results, translation to clinical practice has been limited by the low number of patients treated accordingly. Subgroups of patients with high-priority targets in a large international cohort are shown to benefit from targeted treatment. To support clinical decision making, a novel dataset of neuroblastoma organoids is presented including molecular and drug sensitivity features.

Future developments will explore these new techniques, as well as liquid biopsies and immunotherapies, to improve the chances of children and young adults with cancer by more accurately diagnosing and treating tumors using precision medicine.
The Effect of Corporate Culture and Compensation toward Employee Performance through Employee Motivation after the Merger (PT Bina Pertiwi Case Study)
Authors: Mustofa Agus , Krisnawati Nila , Basbeth Firdaus
Published: June 2023

Changes that occur very quickly cause companies to be more innovative and adaptive to the changes themselves. Employee and company performance is important because it is related to its sustainability in the long term. On the other hand, companies must also pay attention to cultural, compensation, and motivational factors to achieve an effective and efficient performance. This research examines the influence of corporate culture and compensation on employee performance with motivation as an intervening variable. This is a quantitative study using primary data; Structural Equation Modeling (SEM) PLS is used to analyze the data obtained from PT Bina Pertiwi. The researcher obtained 100 respondent data based on predetermined criteria, which were analyzed using SmartPLS software. According to the findings of this study, work culture has a positive impact on employee performance. Employee motivation mediates corporate culture on employee performance, but employee motivation does not mediate compensation effect on employee performance. PT Bina Pertiwi needs to improve the factors that affect employee motivation and performance such as work culture
A Comparative Study of Demand Forecasting for Aftermarket Parts in Heavy Equipment Industry (PT XYZ Case Study)
Authors: Mahmudi  , Kusumastuti Ratih Dyah , Bustaman Yosman
Published: June 2023

The global economic crisis has reached the world today, forcing many customers to become more cost aware in their search for better quality and service, and forcing corporate organizations to discover more effective and efficient ways to compete among them. The main objective of this research is to choose the best forecasting method to predict the demandfor spare parts at PT. XYZ highly fluctuating, and to avoid or minimize stockouts. The demand for high-priced spare partsand capital goods is considered discontinuous if it is random and contributes a large part of the inventory value. Fluctuating demand for goods will be difficult to predict, and inaccurate estimates can cause huge losses for the company due to obsolescence of spare parts or unfulfilled demand for spare parts. Running a successful company operation today requires organizational strength to supply the needs of its customers. This study discusses the appropriate demand forecasting method for the fluctuation demand for spare parts products at an Indonesian companynamed PT. XYZ. This study compares four forecasting methods to predict the demand for spare parts at PT. XYZ is the ABCAnalysis, the Moving Average, the Simple Exponential Smoothing (SES) and Exponential Smoothing (ES) with TrendAdjustment. This study uses demand data for 2017-2020 to forecast demand in 2021 and uses the optimum alpha value of0.4065 for SES which is obtained by calculating using MS Excel Solver and uses alpha value of 0.5 and beta value 0.3 for ES with Trend Adjustment. The performance of this forecasting method is determined based on the smallest mean absolute percentage error and the level of forecasting accuracy (tracking signal) which is close to zero, and the results of this study indicate that the use of the Exponential Smoothing with trend adjustment method has the best performance compared to the other three methods.
The Influence of Marketing Mix towards Consumer Purchase Intention: The Case of Bank Aceh Syariah
Authors: Muhammad Iqbal Fajri  , Heikal Jerry
Published: June 2023

This article examines the influence of Marketing Mix (4Ps) on consumer buying decisions on Islamic banking products, savings, and mortgages. This research method is quantitative. This research population of Bank Aceh Syariah customers using Smart-PLS and surveyed with a Likert scale. The results showed that Price and Place have a highly positive impact on consumer decisions. In contrast, the promotion positively impacts consumer decisions on the sharia mortgage account at Bank Aceh Syariah.
TAGEM Tarafından Geliştirilen Buğday Çeşitlerinin Üreticiler Açısından Değerlendirilmesi; Kayseri İli Örneği
Authors: TAŞCI Rahmi , ÖZERCAN Belma , TARHAN Sinem , SÖYLEMEZ Erkan , HAMARAT Tuğçe , KARABAK Sevinç , BOLAT Merve
Published: June 2023

Bu çalışma Tarım ve Orman Bakanlığı, Tarımsal Araştırmalar ve Politikalar Genel Müdürlüğü (TAGEM)’ne bağlı Tarımsal Araştırma Enstitüleri tarafından geliştirilerek, üreticilerin kullanımına sunulan buğday çeşitlerinin Kayseri ilindeki üreticiler açısından değerlendirilmesini amaçlamaktadır Araştırmada olasılıklı olmayan örnekleme çeşitlerinden kartopu örneklem yöntemi ile zincirleme ulaşım prensibi kullanılarak hedeflenen TAGEM tescilli buğday tohumluğunu kullanan 74 üretici ile görüşülmüştür. Verilerin değerlendirilmesinde; tanımlayıcı istatistikler ve ki-kare analizleri kullanılmıştır. Araştırma sonuçlarına göre, Kayseri ilinde incelenen işletmelerde TAGEM buğday çeşitlerinden Kızıltan 91 çeşidi %67.6 ve Bayraktar 2000 çeşidi ise %25.7 oranı ile üreticiler tarafından en fazla tercih edilen çeşitler olmuştur. Üreticilerin %27’sinin TAGEM buğday çeşitlerinden beklediği verimi elde ettiği, %52.2’sinin ise satışta beklediği buğday satış fiyatını aldığı belirlenmiştir. Üreticilerin %47’si tercih edecekleri buğday çeşitlerinin kılçıklı olmasının önemli bir kriter olduğunu ifade etmiştir. Bölgede artan yaban domuz popülasyonunun kılçıklı buğday tercihini artırdığı söylenebilir. Üreticiler yörede buğday üretiminin sürdürülebilmesi için; verimin kuru koşullarda ortalama 325 kg da-1, sulu koşullarda ise 481 kg da-1 olması gerektiğini ifade etmişlerdir. Uzun uğraşlar sonucu, zaman, genetik materyal, insan kaynağı ve maddi kaynak kullanılarak ıslah edilen verim ve kalite bakımından yüksek değerdeki buğday çeşitlerinin, geliştirme amaçlarına uygun olarak, tavsiye edilen ekolojik bölgelerdeki üreticilere etkili yayım faaliyetleri ve doğru pazarlama kanalları ile ulaştırılması, harcanan emeklerin karşılığını bulması açısından oldukça önemlidir.
Differentiation of human induced pluripotent stem cells into functional lung alveolar epithelial cells in 3D dynamic culture
Authors: Alsobaie Sarah , Alsobaie Tamador , Alshammary Amal , Mantalaris Sakis
Published: June 2023

Introduction: Understanding lung epithelium cell development from human induced pluripotent stem cells (IPSCs) in vitro can lead to an individualized model for lung engineering, therapy, and drug testing.

Method: We developed a protocol to produce lung mature type I pneumocytes using encapsulation of human IPSCs in 1.1% (w/v) alginate solution within a rotating wall bioreactor system in only 20 days without using feeder cells. The aim was to reduce exposure to animal products and laborious interventions in the future.

Results: The three-dimensional (3D) bioprocess allowed cell derivation into endoderm, and subsequently into type II alveolar epithelial cells within a very short period. Cells successfully expressed surfactant proteins C and B associated with type II alveolar epithelial cells, and the key structure of lamellar bodies and microvilli was shown by transmission electron microscopy. The survival rate was the highest under dynamic conditions, which reveal the possibility of adapting this integration for large-scale cell production of alveolar epithelial cells from human IPSCs.

Discussion: We were able to develop a strategy for the culture and differentiation of human IPSCs into alveolar type II cells using an in vitro system that mimics the in vivo environment. Hydrogel beads would offer a suitable matrix for 3D cultures and that the high-aspect-ratio vessel bioreactor can be used to increase the differentiation of human IPSCs relative to the results obtained with traditional monolayer cultures.
Photoelectrochemical biosensor based on SiW12@CdS quantum dots for the highly sensitive detection of HPV 16 DNA
Authors: Cheng Yao , Sun Chaoyue , Chang Yuhua , Wu Jiayin , Zhang Zhihao , Liu Yunqing , Ge Shenguang , Li Zhao , Li Xiao , Sun Liang , Zang Dejin
Published: June 2023

A highly sensitive biosensor for detecting HPV 16 DNA was prepared based on Keggin-type polyoxometalate (SiW12)-grafted CdS quantum dots (SiW12@CdS QDs) and colloidal gold nanoparticles (Au NPs), which exhibited remarkable selectivity and sensitivity upon target DNA detection because of its excellent photoelectrochemical (PEC) response. Here, an enhanced photoelectronic response ability was achieved with the strong association of SiW12@CdS QDs by polyoxometalate modification, which was developed through a convenient hydrothermal process. Furthermore, on Au NP-modified indium tin oxide slides, a multiple-site tripodal DNA walker sensing platform coupled with T7 exonuclease was successfully fabricated with SiW12@CdS QDs/NP DNA as a probe for detecting HPV 16 DNA. Due to the remarkable conductivity of Au NPs, the photosensitivity of the as-prepared biosensor was improved in an I3−/I− solution and avoided the use of other regents toxic to living organisms. Finally, under optimized conditions, the as-prepared biosensor protocol demonstrated wide linear ranges (15–130 nM), with a limit of detection of 0.8 nM and high selectivity, stability, and reproducibility. Moreover, the proposed PEC biosensor platform offers a reliable pathway for detecting other biological molecules with nano-functional materials.
Assessing the potential of Chlorella sp. phycoremediation liquid digestates from brewery wastes mixture integrated with bioproduct production
Authors: Wang Sen , Zhao Qiang , Yu Haiyang , Du Xinxin , Zhang Ting , Sun Tongxin , Song Wenlu
Published: June 2023

Digestates from different anaerobic digesters are promising substrates for microalgal culture, leading to effective wastewater treatment and the production of microalgal biomass. However, further detailed research is needed before they can be used on a large scale. The aims of this study were to investigate the culture of Chlorella sp. in DigestateM from anaerobic fermentation of brewer’s grains and brewery wastewater (BWW) and to explore the potential use of the biomass produced under different experimental conditions, including diverse cultivation modes and dilution ratios. Cultivation in DigestateM initiated from 10% (v/v) loading, with 20% BWW, obtained maximum biomass production, reaching 1.36 g L−1 that was 0.27g L−1 higher than 1.09 g L−1 of BG11. In terms of DigestateM remediation, the maximum removal of ammonia nitrogen (NH4+-N), chemical oxygen demand, total nitrogen, and total phosphorus reached 98.20%, 89.98%, 86.98%, and 71.86%, respectively. The maximum lipid, carbohydrate, and protein contents were 41.60%, 32.44%, and 27.72%, respectively. The growth of Chlorella sp. may be inhibited when the Y(II)–Fv/Fm ratio is less than 0.4.
Reduced metal nanocatalysts for selective electrochemical hydrogenation of biomass-derived 5-(hydroxymethyl)furfural to 2,5-bis(hydroxymethyl)furan in ambient conditions
Authors: Muchharla Baleeswaraiah , Dikshit Moumita , Pokharel Ujjwal , Garimella Ravindranath , Adedeji Adetayo , Kumar Kapil , Cao Wei , Elsayed-Ali Hani , Sadasivuni Kishor Kumar , Al-Dhabi Naif Abdullah , Kumar Sandeep , Kumar Bijandra
Published: June 2023

Selective electrochemical hydrogenation (ECH) of biomass-derived unsaturated organic molecules has enormous potential for sustainable chemical production. However, an efficient catalyst is essential to perform an ECH reaction consisting of superior product selectivity and a higher conversion rate. Here, we examined the ECH performance of reduced metal nanostructures, i.e., reduced Ag (rAg) and reduced copper (rCu) prepared via electrochemical or thermal oxidation and electrochemical reduction process, respectively. Surface morphological analysis suggests the formation of nanocoral and entangled nanowire structure formation for rAg and rCu catalysts. rCu exhibits a slight enhancement in ECH reaction performance in comparison to the pristine Cu. However, the rAg exhibits more than two times higher ECH performance without compromising the selectivity for 5-(HydroxyMethyl) Furfural (HMF) to 2,5-bis(HydroxyMethyl)-Furan (BHMF) formation in comparison to the Ag film. Moreover, a similar ECH current density was recorded at a reduced working potential of 220 mV for rAg. This high performance of rAg is attributed to the formation of new catalytically active sites during the Ag oxidation and reduction processes. This study demonstrates that rAg can potentially be used for the ECH process with minimum energy consumption and a higher production rate.
Differential regulation of Shigella Spa47 ATPase activity by a native C-terminal product of Spa33
Authors: Case Heather B. , Gonzalez Saul , Gustafson Marie E. , Dickenson Nicholas E.
Published: June 2023

Shigella is a Gram-negative bacterial pathogen that relies on a single type three secretion system (T3SS) as its primary virulence factor. The T3SS includes a highly conserved needle-like apparatus that directly injects bacterial effector proteins into host cells, subverting host cell function, initiating infection, and circumventing resulting host immune responses. Recent findings have located the T3SS ATPase Spa47 to the base of the Shigella T3SS apparatus and have correlated its catalytic function to apparatus formation, protein effector secretion, and overall pathogen virulence. This critical correlation makes Spa47 ATPase activity regulation a likely point of native control over Shigella virulence and a high interest target for non-antibiotic- based therapeutics. Here, we provide a detailed characterization of the natural 11.6 kDa C-terminal translation product of the Shigella T3SS protein Spa33 (Spa33C), showing that it is required for proper virulence and that it pulls down with several known T3SS proteins, consistent with a structural role within the sorting platform of the T3SS apparatus. In vitro binding assays and detailed kinetic analyses suggest an additional role, however, as Spa33C differentially regulates Spa47 ATPase activity based on Spa47s oligomeric state, downregulating Spa47 monomer activity and upregulating activity of both homo-oligomeric Spa47 and the hetero-oligomeric MxiN2Spa47 complex. These findings identify Spa33C as only the second known differential T3SS ATPase regulator to date, with the Shigella protein MxiN representing the other. Describing this differential regulatory protein pair begins to close an important gap in understanding of how Shigella may modulate virulence through Spa47 activity and T3SS function.
Assessing respiratory viral exclusion and affinity interactions through co-infection incidence in a pediatric population during the 2022 resurgence of influenza and RSV
Authors: Weidmann Maxwell D. , Green Daniel A. , Berry Gregory J. , Wu Fann
Published: June 2023

Introduction

In the Northeast US, respiratory viruses such as influenza and respiratory syncytial virus (RSV), which were largely suppressed by COVID-19-related social distancing, made an unprecedented resurgence during 2022, leading to a substantial rise in viral co-infections. However, the relative rates of co-infection with seasonal respiratory viruses over this period have not been assessed.

Methods

Here we reviewed multiplex respiratory viral PCR data (BioFire FilmArray™ Respiratory Panel v2.1 [RPP]) from patients with respiratory symptoms presenting to our medical center in New York City to assess co-infection rates of respiratory viruses, which were baselined to total rates of infection for each virus. We examined trends in monthly RPP data from adults and children during November 2021 through December 2022 to capture the full seasonal dynamics of respiratory viruses across periods of low and high prevalence.

Results

Of 50,022 RPPs performed for 34,610 patients, 44% were positive for at least one target, and 67% of these were from children. The overwhelming majority of co-infections (93%) were seen among children, for whom 21% of positive RPPs had two or more viruses detected, as compared to just 4% in adults. Relative to children for whom RPPs were ordered, children with co-infections were younger (3.0 vs 4.5 years) and more likely to be seen in the ED or outpatient settings than inpatient and ICU settings. In children, most viral co-infections were found at significantly reduced rates relative to that expected from the incidence of each virus, especially those involving SARS-CoV-2 and influenza. SARS-CoV-2 positive children had an 85%, 65% and 58% reduced rate of co-infection with influenza, RSV, and Rhino/enteroviruses, respectively, after compensating for the incidence of infection with each virus (p< 0.001).

Discussion

Our results demonstrate that most respiratory viruses peaked in different months and present in co-infections less than would be expected based on overall rates of infection, suggesting a viral exclusionary effect between most seasonal respiratory viruses, including SARS-CoV-2, influenza and RSV. We also demonstrate the significant burden of respiratory viral co-infections among children. Further work is necessary to understand what predisposes certain patients for viral co-infection despite this exclusionary effect.
Computerized music-based intervention module for auditory processing and working memory in older adults
Authors: Ramadas Vaishnavi , Vaidyanath Ramya , Uppunda Ajith Kumar , Viswanathan Sushma
Published: June 2023

Introduction

The contribution of technology to the field of health is vast, both in diagnosis and management. More so, the use of computer-based intervention has become increasingly widespread over the past decade. Human beings experience a decline in auditory processing and cognitive skills as they age, consistent with deterioration of other bodily functions. In addition, speech perception abilities in both quiet and in the presence of noise are impacted by auditory processing abilities and cognitive skills such as working memory. This pilot study explored the use of music as an intervention for improving these skills and employed a computerized delivery of the intervention module.

Method

A battery of tests was carried out to assess the baseline auditory processing and working memory skills in eight older adults between the ages of 56 and 79 years, all of whom had normal hearing. Following the assessment, a short-term computerized music-based intervention was administered. The style of music chosen was Carnatic classical music, a genre widely practiced in Southern India. The intervention module involved note and tempo discrimination and was carried out for a maximum of 10 half-hour sessions. The multi-level intervention module was constructed and administered using Apex software. Following the intervention, the auditory processing and cognitive skills of the participants were reassessed to study any changes in their auditory processing and working memory skills.

Results and discussion

There were positive changes observed in all the auditory processing and some of the working memory abilities. This paper discusses in detail the systematic structuring of the computerized music-based intervention module and its effects on the auditory processing and cognitive skills in older adults.
Research on the evolution law of the seismic wave field based on the explosive source parameters
Authors: Yu Chenglong , Shi Xunxian , Gao Quan , Zhang Xingkai , Wang Fengnian
Published: June 2023

We present a numerical model for blast-induced seismic waves. This model is based on the transformation mechanism of the seismic wave field, and the process of the seismic wave’s generation is divided into two stages. The first stage is the generation of elastic waves. Due to the plastic deformation of the geotechnical medium in this stage, we have established the Euler model to describe it. The second stage is the prorogation of the elastic waves; we have established the Lagrange models to describe this stage. Finally, the influence of the main parameters of the explosive sources (detonation pressure and expansion index) on the seismic wave is analyzed by the established model. The results show that the proposed model in this paper can reasonably predict the evolution law of the seismic wave field based on the explosive source parameters.