bluuebunny/crossref_metadata_2025 huggingface dataset:
Rare A-Type, New Spiro-Type, and Highly Oligomeric Proanthocyanidins from Pinus massoniana
Authors: Zhou Bin , Alania Yvette , Reis Mariana C. , McAlpine James , Bedran-Russo Ana K. , Pauli Guido , Chen Shao-Nong
Published: April 2020

Isolation of underivatized PACs led to three new, structurally unique PACs (1-3) from pine bark. Pinutwindoublin (1) is the first known trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α). Pinuspirotetrin (2) represents the first PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin (3) was elucidated as a mixed A + B type hexamer that consists of the tetramer, peanut procyanidin E, and an A-type dimer (5).
Protein Degradation Profile Reveals Dynamic Nature of 20S CP Small Molecule Stimulation
Authors: Coleman Rachel A. , Paschoal Sobreira Tiago Jose , Aryal Uma , Trader Darci
Published: April 2020

Small molecules have recently been discovered to stimulate the 20S core particle (CP) of the proteasome to degrade proteins, such as a-synuclein. While these studies have focused on particular proteins that are known 20S CP substrates, it is currently unclear how many or what types of proteins may be affected by enhancing this degradation process. We present here a study that utilizes four 20S CP stimulators to determine how each can affect the degradation of proteins in a biochemical assay with purified proteins, an overexpressed GFP-fusion protein in cells, and the effects of stimulators using label-free quantitative proteomic analysis for a more broad understanding on their impact. The results of these studies highlight that the impact of small molecule stimulators of the 20S CP on protein degradation cannot be easily predicted. While 20S CP stimulators will likely increase the degradation of proteins that have significant disorder, such as a-synuclein and tau, we observed different impacts on the degradation of proteins less than 90% disordered. To gain greater insight into the cellular systems that may be affected by 20S CP stimulators, we analyzed the proteome of HEK-293T cells treated with two of our stimulators, AM-404 or miconazole. These results were then compared to cells treated with a proteasome inhibitor, bortezomib. Our results show that 20S CP stimulators affect a smaller number of proteins as compared to bortezomib. The proteomics analysis corroborates our biochemical and GFP-fusion protein results, confirming that the impact of a 20S CP stimulator on protein degradation is dependent on the stimulator. Taken together, this study reveals the dynamic nature of the 20S CP, as small molecule stimulators can have a variety of mechanisms of action to change protein degradation activity. Our studies show that 20S CP stimulation can lead to a decrease in protein levels, more so those proteins that are significantly disordered, and that small molecule stimulators can potentially be tailored to decrease certain protein types.
In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy-Chloroquine Against COVID-19 Main Protease Active Site and ACE2
Authors: Omar Sekiou , Bouziane Ismail , Bouslama Zihad , Djemel Abdelhak
Published: April 2020

COVID-19 is rapidly spreading and there are currently no specific clinical treatments available. The absence of an immediate available vaccine against SARS-CoV-2 made it hard for health professionals to tackle the problem. Thus, the need of ready to use prescription drugs or herbal remedies is urgent. SARS-CoV-2 main protease (Mpro) and Angiotensin Converting Enzyme2 (ACE2) protein structure are made available to facilitate finding solutions to the present problem. In this brief research, we compare the efficacy of some natural compounds against COVID-19 Mpro and ACE2 to that of Hydroxy-Chloroquine in silico.

Molecular docking investigations were carried out using AutoDock. Virtual screening was performed using AutoDock Vina and the best ligand / protein mode was identified based on the binding energy. Amino Acids residues of ligands interactions were identified using PyMOL. According to present research results, Quercetin, Hispidulin, Cirsimaritin, Sulfasalazine, Artemisin and Curcumin exhibited better potential inhibition than Hydroxy-Chloroquine against COVID-19 main protease active site and ACE2. Our provided docking data of these compounds may help pave a way for further advanced research to the synthesis of novel drug candidate for COVID-19.
Doença Renal Aguda em gatos: conquistas e desafios
Authors: Xavier Júnior Francisco Antônio Félix , Morais Glayciane Bezerra , Dutra Marrie Silva , Freitas Mateus Mendes , Araujo Steffi Lima , Araújo Daniel Viana , Evangelista Janaina Serra Azul Monteiro
Published: April 2020

A doença renal aguda (DRA) refere-se a uma síndrome clínica associada a alta morbidade e mortalidade, fazendo parte da síndrome de disfunção de múltiplos órgãos. Em medicina veterinária, estudos sobre a incidência de casos com DRA ainda são pouco elucidados, e a fisiopatologia da lesão renal aguda (LRA) é complexa, sendo caracterizada pela rápida diminuição da função excretora renal e consequente acúmulo de produtos do metabolismo de nitrogênio. Nesse contexto, o objetivo desse estudo foi apresentar a DRA com dados atuais sobre etiologia, patogenia, diagnóstico e tratamento.
Efeito da dieta liquida no desempenho e custo de produção de bezerros leiteiros na fase de cria
Authors: Gurgel Antonio Leandro Chaves , Lima Junior Valdi , Câmara Pedro Lucas Oliveira , Roberto Francisca Fernanda Silva , Silva Luana Andressa Costa , Silva Leonia Régia Costa , Almeida Emizael Menezes , Santana Juliana Caroline Santos
Published: April 2020

Objetivou-se avaliar o efeito da dieta líquida no desempenho de bezerros leiteiros e nos custos operacionais da fase de cria. O experimento foi conduzido, entre os meses de novembro e dezembro de 2015. Foram utilizados 10 animais, distribuídos em delineamento inteiramente casualizado com dois tratamentos (leite integral bovino ou sucedâneo) e cinco repetições. As variáveis de desempenho avaliadas foram: peso, ganho médio diário (GMD), ganho de peso total (GPT), e medidas biométricas (altura de cernelha, comprimento corporal, perímetro torácico, largura de garupa e de peito). Os indicadores econômicos analisados foram: os custos totais com a dieta líquida, com o concentrado e os custos com a mão de obra. Foi avaliado os encargos e impostos, despesas diversas, receita bruta, custo de oportunidade, lucro operacional e lucro total. Foi observado efeito da dieta liquida para peso final, GMD e GPT, os animais que receberam leite integral tiverem GMD 38% superior. Não houve efeito de tratamento para as medidas biométricas. O item de maior participação nos custos de produção foi a dieta 75% e 70% para leite e sucedâneo, respectivamente, seguido pelo custo com mão de obra, o leite tornou o sistema mais oneroso. A receita bruta estimada foi maior para os animais que receberam leite integral (548,5 vs 353,5 US$). O balanço econômico foi negativo para ambas as dietas. Bezerros leiteiros recebendo leite bovino na fase de cria na dieta líquida, apresentam um desempenho superior aos que recebem sucedâneo. Mesmo com desempenho superior, o leite integral tornou o sistema mais oneroso.
Impacto del Programa TARGA en la disminución de casos de sida en el sistema de salud peruano, 1983-2018
Authors: Enríquez Canto Yordanis , Díaz Gervasi Giovani Martín , Menacho Alvirio Luis Alberto
Published: April 2020

Objetivo. Evaluar el impacto del programa de terapia antirretroviral de gran actividad (TARGA) en la disminución de casos estadio sida en Perú en el período 1983-2018.

Métodos. Experimento natural con diseño de series de tiempo interrumpidas durante un período de 36 años. Se analizaron los casos de sida según el año de diagnóstico y la política de acceso universal a la terapia con antirretrovirales del año 2004. Se emplearon datos agregados del Centro Nacional de Epidemiología, Prevención y Control de Enfermedades de 1983 al 2018. Se utilizó la regresión logarítmica lineal y se evaluó el Programa TARGA con un modelo autorregresivo integrado de media móvil (ARIMA, por sus siglas en inglés), a fin de realizar un pronóstico del número esperado de casos anuales de sida, y mediante series de tiempo interrumpidas.

Resultados. Entre 2004 y 2018 hubo un decremento anual de 2,60% de casos (intervalo de confianza del 95% [IC95%]: -3,9 - 1,2). El mejor modelo ARIMA identificado tuvo los componentes: (8, 3, 1). El pronóstico arrojó un total de 32 709 nuevos casos de sida para este período, con una prevención estimada de 10 280 casos. El análisis de series de tiempo arrojó una disminución anual de 134,21 (IC 95%: -160 - -108,60) casos.

Conclusiones. Los hallazgos evidenciaron un aumento sustancial en los casos de sida durante el período 1983-2004, con una reducción significativa posterior a la implementación del Programa TARGA. El programa se confirma como una intervención efectiva para la prevención del número de casos de sida, permite el acceso universal a la terapia con antirretrovirales y otorga otros servicios como pruebas de monitoreo, consejería psicológica y el fomento de la adherencia al tratamiento en las personas que viven con VIH-sida.
Development of composite biscuits made from amadumbe (Colocasia esculenta L. Schott) and soybean (Glycine max L. Merrill) and investigation of their nutritional and organoleptic properties
Authors: Mokhele T.M. , Amonsou E.O. , Tabit F.T.
Published: April 2020

The development of more popular and nutritious amadumbe based food products such as
biscuits from amadumbe may be necessary to improve its utilisation and
commercialization. The aim of this study was to investigate the nutritional and
organoleptic properties of amadumbe-soya composite biscuits. Biscuits were prepared by
combining amadumbe and soya flours at ratios 90:10, 70:30 and 50:50. There was an
increase in the crude protein content of composite biscuits when the percentage of soya
was increased from 10 to 30% and then 50%. Similarly, an increase in the percentage of
soya in composite biscuits gave rise to an increase in the levels of lysine in composite
biscuits. The addition of soya to amadumbe improved the PDCAAS of composite biscuits
to a value of 1 at 50% soya addition. The addition of soya flour to amadumbe flour also
resulted in composite biscuits with an improved overall amino acid profile, mineral
content, protein digestibility and PDCAAS (Protein Digestibility Corrected Amino Acid
Score). The 50% amadumbe-50% soya composite biscuit was identified as having the
optimum quality parameters.
PENGARUH LATIHAN BOX JUMP DAN LATIHAN BOX SKIP TERHADAP KECEPATAN LARI 100 METER PADA MAHASISWA PJKR FKIP UNMUL
Authors: Ruslan Ruslan , Sapulete Jance J. , Buhari Muhammad Ramli
Published: April 2020

Penelitian ini adalah penelitian eksperimen lapangan yang bertujuan untuk mengetahui perbedaan pengaruh latihan box jump dan latihan box skip terhadap kecepatan lari 100 meter pada mahasiswa PJKR FKIP UNMUL. Populasi dan sampel yang dilibatkan dalam penelitian ini adalah mahasiswa PJKR FKIP UNMULyang berjumlah 60 orang. Teknik pengambilan sampel menggunakan teknik random sampling. Namun sesuai dengan rancangan penelitian, maka dibentuk dua kelompok penelitian yang terdiri dari latihan box jump untuk kelompok A dan latihan box skip untuk kelompok B. Pelaksanaan penelitian dilaksanakan selama delapan minggu dengan frekuensi latihan sebanyak 3 kali seminggu. Berdasarkan hasil analisis data dengan menggunakan rumus uji-t berpasangan dan uji-t tidak berpasangan pada taraf signifikan 5%, maka dapat disimpulkan sebagai berikut : Ada pengaruh yang signifikan latihan box jump terhadap kecepatan lari 100 meter (to = 15,820 > tt =2,045). Ada pengaruh yang signifikan latihan box skip terhadap kecepatan lari 100 meter (to = 11,914 > tt = 2,045). Ada perbedaan pengaruh yang signifikan antara latihan box jump dan latihan box skip terhadap kecepatan lari 100 meter (to = 8,149 > tt = 2,000)
HUBUNGAN KEKUATAN OTOT TUNGKAI DAN SUDUT TAPAK KAKI DENGAN KECEPATAN LARI 50 METER
Authors: Kurniawan Febi , Afriandi Rolly
Published: April 2020

Penelitian ini bertujuan untuk mengetahui hubungan kekuatan otot tungkai, dan sudut tapak kaki dengan kecepatan lari 50 meter. Penelitian ini bersifat deskriptif terhadap dua variabel bebas dan satu variabel terikat. Populasi pada penelitian adalah Siswa SMK Negeri 1 Karawang. Sampel yang digunakan adalah siswa kelas X dengan jumlah 80 orang. Teknik analisis data yang digunakan analisis korelasi tunggal dan korelasi ganda dengan menggunakan fasilitas komputer melalui program SPSS. Berdasarkan hasil analisis data dapat disimpulkan sebagai berikut: (1) Ada hubungan yang signifikan kekuatan otot tungkai dengan kecepatan lari 50 meter siswa, diperoleh nilai korelasi observasi ( r0 ) = 0,627 > nilai korelasi tabel ( rt ) pada taraf signifikan 95% = 0,220, (2) Ada hubungan yang signifikan sudut tapak kaki dengan kecepatan lari 50 meter, diperoleh nilai korelasi observasi ( r0 ) = 0,674 > nilai korelasi tabel ( rt ) pada taraf signifikan 95% = 0,220, dan (3) Ada hubungan yang signifikan antara kekuatan otot tungkai dan sudut tapak kaki dengan kecepatan lari 50 meter, diperoleh nilai korelasi observasi ( R0 ) = 0,689 > nilai korelasi tabel ( rt ) pada taraf signifikan 95% = 0,220
TEACHER PERFORMANCE MANAGEMENT CYCLE BASED ON EMPLOYEE’S TARGET
Authors: Ahyar Aziz Luki , Maftukhin  , Patoni Ahmad , Naim Ngainun , Asrof Safi’I  , Akhyak
Published: April 2020

The purpose of this study is to know how teacher performance management as a continuous performance process to equalize individual teacher goals and educational institutions also teacher performance series starting from the planning, implementation and evaluation phase which are oriented to minimum work standards in order to obtain income eligibility, benefits, and promotion or rank only which resulting in the performance of teachers dwelling on matters of an administrative nature and setting aside performance processes that produce output and outcome according to the objectives of educational institutions. This research used a qualitative research design by concerning to a phenomenon approach. Data collection techniques used by some steps such as observation, interviews and documentation. Data analysis included single site analysis and cross-site analysis with data analysis techniques; data reduction, data presentation, and conclusions. This research produced four main findings among others; first, in pre-cycle stage with preparation for assessment and creating a teacher performance assessment team; second, the phase of planning with the phase of defining, discussing roles, responsibilities, and measurable expectations; third, the phase of coaching with the phase of observation, monitoring, support, feedback, and appreciation; the four phase of the teacher performance management cycle are performance evaluations.
Evaluación de la fuerza muscular en niños: una revisión de la literatura
Authors: Negro Prieto Diana Paola , Cuervo Beltrán Nathalie Alexandra , Ramírez Ramírez Daniela Andrea , Rodríguez Sánchez Laura Daniela , Sánchez Cardozo Anyi Lorena , Serrano Gómez María Eugenia
Published: April 2020

Introducción: la fuerza muscular es un indicador importante de la función neuromuscular y un componente de la aptitud física esencial para el desempeño en actividades cotidianas. Su alteración puede causar deficiencias funcionales, afectar la independencia y los roles que desempeña una persona. Por esto, evaluar la fuerza muscular en niños es necesario para determinar el grado de rendimiento motor e identificar riesgos asociados al crecimiento y al desarrollo. Objetivo: describir el estado del arte relacionado con la utilización de esca-las de valoración de la fuerza muscular en niños entre 3 y 8 años de edad. Materiales y Métodos: se realizó una revisión de la literatura empleando la estrategia PICO, con bús-queda bibliográfica en las bases de datos Ovid, Sage, Science Direct, Proquest y Clinical Key. Resultados: en la fase inicial del proceso de cribado se identificaron 69 registros ele-gibles por título y resumen, de los cuales se excluyeron 56 por no cumplir con los criterios de inclusión. Adicionalmente se identificaron 3 libros con información relevante, razón por la cual fueron tenidas en cuenta 16 referencias que hacen parte de la síntesis cualitativa del presente estudio. Conclusiones: estrategias y pruebas como la dinamometría, la Functio-nal Strength Measurement, el Test de Competencias Motoras de Bruininks Oseretsky, el Fitness Testing Preschool Children y FUPRECOL son herramientas que permiten evaluar la fuerza muscular en la infancia, y aportan elementos importantes en la identificación tem-prana de factores de riesgo para la salud de la persona.
Efecto del cambio de la terapia antirretroviral en la falla virológica en una cohorte de pacientes que conviven con el VIH en Medellín, Antioquia, Colombia
Authors: Gómez Hernández Andrea Juliana , Medina Vasquez Lina María , Molina Castaño Carlos Federico , Botero Garcés Jorge Humberto , Alzate Ángel Juan Carlos
Published: April 2020

Objetivo: determinar el efecto del cambio en la terapia antirretroviral sobre el control virológico en una cohorte de pacientes VIH positivos de una institución prestadora de servicios de salud en Medellín, Antioquia (Colombia)) en el año 2017. Materiales y métodos: estudio observacional analítico transversal, comparativo entre pacientes que cambiaron y no cambiaron el esquema inicial de terapia antirretroviral. Se realizó en una cohorte de 1245 pacientes que conviven con el VIH. Resultados: un total de 322 pacientes fueron evaluados. El principal motivo de cambio fue la presencia de efectos adversos a la terapia antirretroviral, seguido de la falla virológica sin genotipo e intolerancia a la terapia antirretroviral. La falla virológica, RP 1,4 IC95% (1,2-1,6, p 0,00), el tener genotipo, RP 1,2 IC95% (1,1-1,3, p 0,00) y el padecer una infección oportunista, RP 1,3 IC95% (1,0-1,6, p 0,03), se asociaron a mayor número de cambios a la TAR. La adherencia a la terapia antirretroviral, RP 0,18 IC95% (0,1-0,3, p 0,00) y la toma de otros medicamentos no relacionados al VIH (RP 0,6, IC95% 0,4-0,8, p 0,005) se asociaron a menor frecuencia de cambio de la terapia antirretroviral. El cambio de la terapia antirretroviral (OR ajustado 3,4, IC 95% (2,0-5,8), continúa siendo el factor pronóstico más importante para falla virológica. Conclusión: el cambio de la terapia antirretroviral, definida en este estudio como la principal variable de exposición, representa el principal factor de riesgo para falla virológica, incluso cuando fue ajustado por otras variables
FAKTOR EKSTERNAL DAN FAKTOR INTERNAL TERHADAP MINAT BERWIRAUSAHA PADA SISWA SMK YAYASAN PENDIDIKAN ISLAM DARUSSALAM CERME GRESIK
Authors: Ruswati Ine
Published: April 2020

Penelitian ini bertujuan melakukan pengujian Analisis Faktor Eksternal dan Faktor Internal TerhadapMinat Berwirausaha Pada Siswa SMK yayasan pendidikan Islam Darussalam Cerme Gresik. Kemudiandilakukan tinjauan pustaka dan penyusunan hipotesis, juga data yang diperolah dari penyebarankuesioner terhadap 113 siswa SMK YPI DARUSSALAM Cerme menggunakan teknik Total sampling.Pengujian dilakukan dengan menggunakan analisis Regresi Linear Berganda. Hasil analisismemperlihatkan bahwa Motivasi Berpengaruh Terhadap Minat Berwirausaha SMK YPI Darussalam 1Cerme, Harga Diri Berpengaruh Terhadap Minat Berwirausaha SMK YPI Darussalam 1 Cerme,Kreativitas Berpengaruh Secara Negatif Terhadap Minat Berwirausaha SMK YPI Darussalam 1 Cerme,Risk Taker Tidak Berpengaruh Terhadap Minat Berwirausaha SMK YPI Darussalam 1 Cerme,Lingkungan Keluarga Tidak Berpengaruh Terhadap Minat Berwirausaha SMK YPI Darussalam 1 Cermedan Lingkungan Sekolah Berpengaruh Terhadap Minat Berwirausaha SMK YPI Darussalam 1 Cerme.
Quantitation of Gait and Stance Alterations Due to Monosodium Iodoacetate–induced Knee Osteoarthritis in Yucatan Swine
Authors: LaVallee Katherine T , Maus Timothy P , Stock Joseph D , Stalder Kenneth J , Karriker Locke A , Murthy Naveen S , Kanwar Rahul , Beutler Andrea S , Unger Mark D
Published: April 2020

Knee osteoarthritis is one of the most common causes of chronic pain worldwide, and several animal models have been developed to investigate disease mechanisms and treatments to combat associated morbidities. Here we describe a novel method for assessment of locomotor pain behavior
in Yucatan swine. We used monosodium iodoacetate (MIA) to induce osteoarthritis in the hindlimb knee, and then conducted live observation, quantitative gait analysis, and quantitative weight-bearing stance analysis. We used these methods to test the hypothesis that locomotor pain behaviors
after osteoarthritis induction would be detected by multiparameter quantitation for at least 12 wk in a novel large animal model of osteoarthritis. MIA-induced knee osteoarthritis produced lameness quantifiable by all measurement techniques, with onset at 2 to 4 wk and persistence until the
conclusion of the study at 12 wk. Both live observation and gait analysis of kinetic parameters identified mild and moderate osteoarthritis phenotypes corresponding to a binary dose relationship. Quantitative stance analysis demonstrated the greatest sensitivity, discriminating between mild
osteoarthritis states induced by 1.2 and 4.0 mg MIA, with stability of expression for as long as 12 wk. The multiparameter quantitation used in our study allowed rejection of the null hypothesis. This large animal model of quantitative locomotor pain resulting from MIA-induced osteoarthritis
may support the assessment of new analgesic strategies for human knee osteoarthritis.
Сравнение результативности регуляторов роста растений различных классов при возделывании кормовой свеклы сорта Эккендорфская желтая (многосемянная) и брюквы сорта Вышегородская
Authors: Зольникова Евгения Владимировна , Постников Андрей Николаевич , Калабашкина Елена Владимировна , Абрамкина Людмила Пиркулыевна
Published: April 2020

Изучен отдельный элемент технологического процесса возделывания кормовой свеклы сорта Эккендорфская желтая (многосемянная) и брюквы сорта Вышегородская — опрыскивание посевов препаратами индолил-3-уксусная кислота, Эпин-экстра, 6-бензиламинопурин. Выявлен наиболее результативный препарат на этих посевах и рассчитана результативность вышеуказанных препаратов. Эксперимент проводили на территории Московской области в течение 3 лет (2010 – 2012 гг.). Полученные значения показателей результативности препаратов показали, что экономически целесообразно использовать препарат Эпин-экстра при опрыскивании посевов кормовой свеклы и брюквы, так как при этом достигнуты самая высокая урожайность культур — 52,5 и 55,1 т/га соответственно, сравнительно невысокие финансовые затраты на внесение препарата — 7584,09 руб./га, самый высокий уровень индивидуальной рентабельности — 37,3 и 39,1 % соответственно. Применение регуляторов роста растений при опрыскивании посевов кормовой свеклы сорта и брюквы способствует повышению урожайности корнеплодов до 8,5 и 17,0 % соответственно.
Овощеводство Северо-Запада России: современное состояние и перспективы
Authors: Спиридонов Анатолий Михайлович , Данилова Татьяна Алексеевна , Адрицкая Наталья Анатольевна
Published: April 2020

Овощеводство России представлено открытым и защищённым грунтом, где выращивают ассортимент овощных культур, насчитывающий более 30 видов. В силу природных и антропогенных факторов овощеводство регионально видоспецифично. В условиях рискованного земледелия, куда относится и Северо-Запад РФ, возделывают ограниченный набор овощных культур в открытом грунте и весь арсенал видов в условиях защищённого грунта. Оценено современное состояние и перспективы развиия отрасли овощеводства России на примере Северо-Западного федерального округа (СЗФО). По развитости, технологической оснащённости и экономической стабильности предприятия защищённого грунта СЗФО являются передовыми в регионе и стране. Именно на этих предприятиях внедряют элементы технологий ресурсобережения при производстве продукции, в них рационально организован труд, производится экологически безопасная продукция. Овощеводство имеет широкие перспективы, основанные на использовании новых высокоурожайных и экологически пластичных сортов основных овощных культур, внедрении новых технологий возделывания, инновационных средств удобрения и защиты растений, а также модернизированных средств механизации всех звеньев технологического процесса возделывания овощных культур.
Hubungan Profesionalisme Pendidik Pendidikan Anak Usia Dini dengan Efektivitas Pembelajaran PAUD di Kota Gorontalo
Authors: Zubaidi Mohamad
Published: April 2020

Profesionalisme pendidik mempunyai hubungan yang erat dengan efektivitas pembelajaran pada pendidikan anak usia dini. Penelitian ini akan melihat apakah ada hubungan antara profesionalisme pendidik pendidikan anak usia dini dengan efektivitas pembelajaran PAUD di Kota Gorontalo. Tujuan penelitian ini adalah mengetahui hubungan antara profesionalisme pendidik PAUD dengan efektivitas pembelajaran PAUDdi Kota Gorontalo. Penelitian ini menggunakan pendekatan penelitian kuantitatif, dengan analisis data menggunakan analisis statistik. Hasil penelitian ini menunjukkan bahwa profesionalisme pendidik PAUD mempunyai hubungan yang signifikan dengan efektivitas pembelajaran dan hubungan tersebut mempunyai nilai yang tinggi. Karena itu, dari hasil penelitian ini direkomendasikan kepada para pendidik PAUD untuk meningkatkan profesionalisme melalui peningkatan keterampilan baik melalui diklat PAUD maupun peningkatan kualifikasi pendidikannya.
Government Evaluations in Japan’s Municipalities Based on Nationwide Survey Data
Authors: Moteki Yasutoshi
Published: April 2020

Government evaluations in Japan are linked to the business culture. This study investigated government evaluations in cities and towns/villages using primary survey data from 2014 and 2015. The dominant method was Jimujigyo Hyoka, a cross-sectional evaluation of programs using performance measures, implemented by 80% of municipalities with government evaluations. Cities were more likely than smaller municipalities to have implemented evaluations (84.6% vs. 37.4%). Almost none of the smaller municipalities had implemented evaluations because of the lack of resources. The main problems were the lack of clarity and internal consistency in the results and the effort and workload involved.
Liturgy affects the parameters of gas discharge visualization, acupuncture points and neuro-endocrine-immune complex
Authors: Popovych Igor L. , Babelyuk Valeriy Ye. , Zukow Walery , Muszkieta Radosław , Dubkova Galyna I. , Nesterova Liliya F. , Hubyts’kyi Viktor Y. , Bilas Volodymyra R. , Musiyenko Vira Y. , Seniv Teodor S. , Mis’ko Volodymyr T. , Babylyuk Roman V. , Yaremchuk Yaroslava M. , Barylyak Liliya G. , Gozhenko Anatoliy I.
Published: April 2020

Background. The impact of religion on the human body has been the subject of a number of studies, including ours. The proposed article is a continuation of them. Purpose of the study: to detect in the supervised observation the characteristic effects of the Liturgy on some biophysical and physiological parameters of healthy people. Materials and methods. Under a observations were 10 healthy men by age 26-56 years. In the morning in basale condicions registered parameters of Gas Discharge Visualization (GDV), electroskin conductivity of Points Acupuncture (CPA), Heart Rate Variability (HRV), Leukocytogram, phagocytic function of neutrophils as well as anxiety and plasma levels of main adaptive hormones: Cortisol, Triiodothyronine and Testosterone. After testing, one volunteer went to a chapel to attend a half-hour Liturgy, and another volunteer was in the park nearby, serving as a control. After that, both participants returned to their duties, and after 1 hour all tests were repeated. Results. The characteristic effects of the Liturgy are: minimization the decrease in CPA TR(X) and G8Dg on the right, reactive anxiety, cortisolemia and one marker of vagal tone; limitation the increase in the area of the GDV in the frontal projection and the intensity of phagocytosis; initiation an increase in plasma testosterone, entropy of the leukocytogram and the proportion of rod-core neutrophils, as well as reversion the decrease in the tone of the vagus and the decrease of the energy of the virtual seventh chakra, which takes place in the control group. Conclusion. Liturgy affects the parameters of gas discharge visualization, acupuncture points and neuro-endocrine-immune complex in healthy men.
Tugas Citation ESDM - 130217038 Eunike Gratia
Authors: gratia eunike
Published: April 2020

Tugas ESDM Review, Citation
Makalah perangkat keras monitor
Authors: saputri Dwina rahayu
Published: April 2020

Perangkat keras (hardware) merupakan perangkat yang dapat dilihat dan disentuh secara langsung oleh manusia yang berfungsi untuk mendukung proses komputerisasi, Perangkat keras komputer adalah semua bagian fisik komputer, dibedakan dengan data yang berada di dalamnya atau yang beroperasi di dalamnya sedangkan perangkat lunak merupakan perangkat yang dapat dilihat namun tidak dapat disentuh secara langsung oleh manusia. Hardware dapat bekerja berdasarkan perintah yang telah ditentukan ada padanya, atau yang juga disebut dengan dengan istilah instruction set.Secara fisik, Komputer terdiri dari beberapa komponen yang merupakan suatu sistem. Apabila salah satu komponen tidak berfungsi, akan mengakibatkan tidak berfungsinya proses-proses yang ada komputer dengan baik. Komponen komputer ini termasuk dalam kategori elemen perangkat keras (hardware).
The Conceptual and Methodological Mayhem of “Screen-time”
Authors: Kaye Linda Katherine , Orben Amy , Ellis David Alexander , Hunter Simon C. , Houghton Stephen
Published: April 2020

Debates concerning the impacts of screen-time are widespread. Existing research presents mixed findings, and lacks longitudinal evidence for any causal or long-term effects. We present a critical account of the current shortcomings of the screen-time literature. These include: poor conceptualisation, the use of non-standardised measures that are predominantly self-report, and the issues with measuring screen-time over time and context. Based on these issues, we make a series of recommendations as a basis for furthering academic and public debate.
Review Ekonomika Sumber daya manusia
Authors: Saputra Muh Rivaldi Andhies
Published: April 2020

Pada era sekarang yaitu era industri 4.0 segala aktivitas perusahaan sudah mulai bergeser dari yang semulanya bersifat offline sekarang sudah berubah menjadi online, hal ini dikarenakan berkembang pesatnya teknologi digital yang ada. Perkembangan teknologi yang berbasis online ini mebawa manfaat seperti membuat biaya lebih ekonomis dan mempersingkat jarak, waktu, dan ruang. Namun, perkembangan teknologi juga membawa dampak yang cukup negative bagi perusahaan dimana, menjadikan dunia bisnis semakin sulit untuk bersaing secara sehat. Sekarang sudah mulai banyak perusahaan baru yang mulai bermunculan seperti banyaknya startups, dengan kelincahan mereka yang mampu untuk bersaing bahkan mengikis pasar dari perusahaan yang sudah beridiri cukup lama. Maka dari itu perusahaan-perusahaan yang sudah cukup lama memerlukan terobosan untuk bisa tetap bersaing pada pasar mereka. Salah satu terobosan tersebut adalah dengan membuat organisasi yang positif sehingga karyawan bekerja bukan hanya untuk memenuhi kewajiban mereka. Namun, juga untuk berkarya dan berguna bagi orang lain. Kenyataannya banyak perusahaan yang gagal bukan karena mereka tidak bisa beradaptasi dengan faktor eksternal seperti perkembangan teknologi, namun yang terpenting adalah faktor internalnya yaitu kenyamanan karyawan agar tidak hanya menjalankan kewajibannya tapi juga untuk berkarya dan berguna bagi orang lain.
What makes a market transaction morally repugnant?
Authors: Leuker Christina , Samartzidis Lasare , Hertwig Ralph
Published: April 2020

For many people, it is morally impermissible to put kidneys, jury duty exemptions, or permits for having children on the free market. All of these are examples of repugnant transactions—market transactions that third parties want to prevent. In two studies (N = 1,554), using respondents’ judgements of 51 different market transactions across 21 characteristics, we show that repugnance can be characterized along five higher-order dimensions: moral outrage, need for regulation, incommensurability, exploitation, and unknown risk. Repugnance toward the 51 market transactions was highly consistent across two samples. Our results can help identify mismatches between public sentiments and current regulations (selling carbon emissions is currently legal but considered repugnant), anticipate responses to novel markets that have not been publicly scrutinized (often arising from technological advances, such as markets for “designer babies”), and help design less repugnant markets (e.g., by making the risks involved in a transaction known to sellers).
Factors That Affect Teachers’ Coping with Cyberbullying: Implications for Teacher Education Programs
Authors: Hafsha Aixa
Published: April 2020

Over the last decade, with the emergence of cyberbullying (CB) in the education arena, teachers at all stages of the education system have confronted new challenges. Few studies have looked into the factors that affect the coping. This study examines teaching background factors and personal-psychological factors that may affect teachers coping with CB. Six hundred forty-four teachers (81.5% female) completed self-reported questionnaires referring to CB coping, empathy level, communication with students level and teachers’ self-efficacy. Results have revealed that overall, teachers were reported on moderate levels of coping with CB. Pearson correlations indicated that CB coping is correlated positively with high levels of empathy, communication with students, and teachers’ self-efficacy. A multiple regression analysis for predicting effective coping with CB exposed a significant model showing that seniority, empathy, and high levels of teachers’ communication with students may predict teachers’ coping with CB, whereas age and gender do not. Furthermore, the results of a mediation model have revealed that empathy and teacher self-efficacy mediate the influence of teacher communication with students on CB coping. However, we found no direct effect of teacher communication with students on CB coping. The results have significant implications for teachers’ education programs.
Assessing the Interdependence of SSC EFL Testing, Teaching and Materials; an Evaluation of SSC Curriculum
Authors: Hafsha Aixa
Published: April 2020

Secondary School Certificate (SSC) is an “O” level equivalent grade in Bangladesh. Numerous studies found that SSC EFL tests have harmful backwash effects as teachers and learners have become “test-wise”, because same test pattern continues since 1996. It is a sign of deviation from the SSC curriculum which is designed following CLT principles. It is further criticised that SSC students and their teachers exceedingly depend on commercially published Note/Guidebooks although there are two officially published textbooks known as English For Today (English 1st Paper) and English Grammar and Composition (English 2nd Paper) edited and published by National Curriculum Textbook Board (NCTB). Thus, this study was designed to appraise the interdependence of SSC EFL testing, teaching and teaching-learning materials in the light of the guidelines of the SSC English curriculum. To collect data, in this study, we used two methods: namely document analysis and survey. The former includes SSC curriculum and English test papers, while the latter involves a questionnaire. The analysis of the data revealed that SSC EFL tests affect teaching of English at SSC level and also influence teachers and students when they select reading/teaching materials. It is also found that the curriculum guidelines are not followed in the classroom teaching and test design. Exam centric teaching is prevalent everywhere. We noticed a mismatch among the mandated curriculum, classroom teaching and the teaching materials used which might foil the endeavour to achieve the objectives of the secondary English curriculum. Conventional test pattern immensely influences the teachers’ teaching and their selection of teaching materials. This study recommends some specific measures including the reformation of SSC EFL testing.
The Development of Assessment Instruments with Problem Posing Methods to Measure Students Creative Thinking Ability in Acid Base Materials
Authors: Dewi Pitri Rahma , Erna Maria , Rasmiwetti Rasmiwetti
Published: April 2020

Students creative thinking skills play an important role in achieving educational goals, especially in understanding chemical material. Education is currently focused on developing Higher Order Thinking Skills and creative thinking skills that are one of the highest level of thinking. The teacher as one of the creative drivers is an important factor to increase student creativity in school. This study aims to develop creative thinking assessment instruments with problem posing methods on acid-base material and conduct tests to determine the responses of educators and students. This research used the Research and Development method which refers to the Borg and Gall model. The sample in this study amounted to 60 class XI high school students in Rokan Hulu district. The results of the validation of the assessment instruments were in average of more than 0.78 (very good) and had a test reliability on the main field test of 0.88 which was classified as very high. The level of difficulty ranged from 0.29 - 0.56 with the category of difficult and moderate. The ability to differentiate the problem is good enough. And the results of student responses amounted to 50.4 on the questionability readiness questionnaire, 8.1 on the questionnaire for sufficient time. Whereas the result of the teacher's response was 57.3 on the question eligibility questionnaire.
Improving Students Mathematical Understanding by Using Discovery Learning Models for Senior High School Students in Kampar District
Authors: Imayati Imayati , Kartini Kartini , Zulkarnain Zulkarnain
Published: April 2020

Mathematical understanding is a very important ability possessed by students in solving mathematical problems. The purpose of this study is to find out the improvement in students mathematical understanding using discovery learning models. This research was a quasi-experimental study with a non equivalent control group design. The samples in this study were SMAN 1 Bangkinang, SMAN 1 XIII Koto Kampar and SMAN 2 Koto Kampar Hulu taken by purposive sampling technique. The data analysis technique used was the t test, and the Mann-Whitney U test. The results showed an increase in mathematical understanding of students learning using discovery learning models is better than students learning to use conventional learning models at the top level of school, medium and as a whole, but at the lower level schools have not increased.
WeMPiC protocol to prevent Deep Venous Thrombosis in patients with neurosurgical diseases
Authors: Thapa Amit , KC Bidur , Shakya Bikram , Chakradhar Rupesh
Published: April 2020

Background: Deep Venous Thrombosis is a common yet difficult problem to prevent in neurosurgical patients. Recent trials did not find sufficient evidence to support use of graduated compression stockings, however we believe, this inefficiency may be due to the method of application which needs to be modified. We have been following a patient specific mechanical prophylaxis protocol, nicknamed WeMPiC. This study aims to evaluate the effectiveness of WeMPiC protocol.

Methods: An observational cohort study was performed including consecutive patients admitted to neurosurgical ICU who were bedridden for >7 days between April 2014 and September 2017. We developed WeMPiC protocol of early weaning off, early mobilization, limb physiotherapy and alternate two hours on and off application of thigh length graduated compression stockings. Lower limbs compression ultrasound studies were performed on alternate days.

Results: One hundred thirty-one patients were included in the study. Mean age of patients was 53.7+ 20.6 years. Of these patients, 52.7% had stroke (91% had hemorrhages), 32.1% had head injury and 7.6% each had spine problem and brain tumor each. five (3.8%) developed deep venous thrombosis on the 4th and 6th day of ICU stay, mainly in popliteal veins (2.3%) and femoral veins (1.5%). Deep venous thrombosis was associated with younger age (47 years, p=0.005), ICU stay (13 days, p=0.014), Wells’ score (4.6, p<0.0001) and Poor Glasgow Coma Score at presentation (9, p=0.004). Power of study calculated for the cohort incidence of 3.8% was 100%. Cost benefit of $336 with WeMPiC protocol was seen as compared to the Low molecular weight heparin prophylaxis over four weeks.

Conclusions: Compared to incidence of 12.1% in CLOTS 3 trial among the unexposed patients, we report a risk reduction of 8.3% with WeMPiC protocol which is cost effective and highly applicable in resource constraint scenarios.
Fransa ve Belçika’dan Gelen Türk Öğrencilerin Türkçe’ye İlişkin Görüşleri: Anadolu Üniversitesi Örneği
Authors: AYDOĞU Cihan , GÜNDOĞDU Bahtınur , ERCANLAR Meltem
Published: April 2020

ÖZ: İkinci dünya savaşından sonra Batı Avrupa ülkelerinin iş gücüne ihtiyaç duymasıyla beraber Türkiye’den önemli sayıda göç olmuştur. Avrupa’ya göç eden vatandaşlarımız bir sure sonra aile kurmaya ve kalıcı olmaya başlamışlardır. Bununla beraber bir takım sorunlar meydana gelmiştir, en önde gelenleri bulundukları ülkeye uyum sağlayamama ve çocukların eğitim sorunu olarak sıralayabiliriz. Bu göçmen çocukların yaşadıkları eğitim sorunlarının nedeni anadillerinde yetersiz olmalarından kaynaklanmaktadır. Henüz birinci dildeki becerileri edinemeyen göçmen çocuklar ikinci dili verimli bir şekilde öğrenmemektedir. Son bir kaç yıldır tersine bir göç gözlenmektedir. Dönüş göçünün temel sebeplerini aile ile beraber dönen çocuklar, evlilik için dönenler, eğitim için dönenler, daha iyi hayat standartları için dönenler ve kaçış yolu olarak sıralayabiliriz. Bu çalışma nitel bir araştırma olup, amaç Fransa ve Belçika’da doğup Türkiye’ye dönen göçmen öğrencilerin anadilleri Türkçeye ilişkin görüşlerini ve Türkçe kullanım deneyimlerini betimlemek ve ortaya koymaktır. Anahtar sözcükler: göç, anadil öğrenimi, geri dönüş, ikinci dil, görüngübilim
Türkçe Eğitiminde Yakın Okuma Yönteminden Yararlanma Üzerine Bir Çalışma (Bir Etkinlik Örneği)
Authors: ŞEN Erhan
Published: April 2020

Özet: Dil ve edebiyat eğitiminde okuma becerisine ilişkin alanyazınında birçok
yöntem ve strateji önerilmektedir. Son dönemlerde önerilen bu yöntemlerden biri
de yakın okumadır.  Bu yönteme ilişkin
olarak Türkçe ders kitaplarında ve Türkçe Dersi Öğretim Programında (2018) kuramsal
ve pratik yönden bir eksiklik olduğu söylenebilir. Bu yönteme herhangi bir
gönderme yapılmamıştır. Yakın okuma öğrencinin eleştirel düşünme, güç bir metni
akademik yönden irdeleme, ayrıntıları sorgulama gibi birçok yönden
yetkinleşmesine hizmet eden bir yöntemdir. Bu nedenle Türkçe eğitiminde
öğretmen ve öğrenciler yakın okumaya ilişkin bilinçlendirilmeli ve bu yöntemin içselleştirilmesi
için fırsatlar yaratılmalıdır. Nitel ve betimsel bir yaklaşımla tasarlanan bu
çalışmanın temel amacı Türkçe eğitiminde yakın okuma yönteminden nasıl
yararlanılacağını bir etkinlik taslağıyla somutlaştırmaktır. Yakın okumanın
etkin kullanımı için öncelikle anlaşılması güç metinler belirlenmeli ve bunlar
üzerine yakın okumalar gerçekleştirilmelidir. Bu amaçla 8. sınıf öğrencilerinin
seviyelerinin az üstünde olan ve çözümlenmesi bir kılavuza gereksinim duyulan
“İhtiyar Çilingir” adlı öyküye ilişkin yakın okuma temelli bir etkinlik taslağı
hazırlanmıştır.
Türkçe Sözlüklerin Sözcük Vurgusu Bakımından Karşılaştırılması
Authors: ÇELEBİ Safa , BÖREKÇİ Muhsine
Published: April 2020

Türkçe dil bilgisi kitaplarında ve telaffuz sözlüklerinde Türkçede sözcük vurgusunun genellikle son hecede olduğu belirtilmekte, istisnalar için verilen örneklerde kimi zaman tutarsızlıkların olduğu görülmektedir. Bu durum sözlük kullanıcılarının özellikle de Türkçeyi yabancı dil olarak öğrenenlerin çelişki yaşamalarına sebep olmaktadır. Bu araştırmada, Türkçe sözlüklerin vurgu bakımından tutarlılık durumlarının sözcük türlerine göre tespit edilmesi amaçlanmaktadır. Betimsel yöntemin kullanıldığı araştırmada “var olan bir durumu var olduğu şekliyle betimlemeyi amaçlayan tarama modeli kullanılmıştır. Araştırmanın örneklemini birden fazla heceli 300 basit, 100 türemiş ve 100 birleşik olmak üzere toplam 500 sözcük oluşturmaktadır. Bu sözcüklerin TDK Türkçe Sözlük (TS), Sesli Türkçe Sözlük (STS) ve Konuşma Dili ve Türkçenin Söyleyiş Sözlüğü’nde (KDTSS) bulunması ve Yazılı Türkçenin Kelime Sıklığı Sözlüğü”nde en sık geçen sözcüklerden olması göz önünde bulundurulmuştur. “KDTSS”de ve TS’de vurgu yerleri belirlenen sözcüklerin sesletimleri, STS’den indirilip kaydedilmiştir. Kaydedilen sesletimler Praat 6.0.12 programıyla temel frekans (F0) bakımından çözümlenerek sözcüklerin vurguları seslem düzeyinde tespit edilmiştir. Araştırmadan elde edilen sonuçlar, üç sözlüğün genel vurgu tutarlılık oranının düşük (%45,8) olduğunu göstermiştir. Ayrıca STS’de vurgu bakımından sesletim hatalarının olduğu ortaya çıkmıştır.
HEM’lerde Suriyeliler’e Türkçe Öğreten Öğretmenler Üzerine Bir Araştırma
Authors: PİLANCİ Hülya , ÇALIŞIR ZENCİ Sevgi , SALTIK Olcay , YAŞAR Sebahat
Published: April 2020

Türkiye’de Türkçeyi ikinci dil olarak öğrenen en kalabalık grupları, son yıllarda çeşitli sebeplerle Türkiye’ye göç eden yabancılar oluşturmaktadır. Göçmenlerin, geldikleri ülkelerin toplumlarıyla etkileşiminin sağlanmasında devlet politikalarının ortaya koyduğu yasalar ve kurallar, ev sahibi toplumun özellikleri ve tutumları, konunun eğitimbilim açısından hangi oranda ele alındığı belirleyici olmaktadır. Sosyokültürel ve sosyoekonomik açıdan ele alındığında Türkçe öğretiminin uyumun en önemli parçası olduğu ortaya çıkmaktadır. Türkçe öğrenme ihtiyacının sadece geçici koruma altındaki Suriyeliler’in değil tüm uluslararası koruma altında olanlar ve düzensiz göç yoluyla gelenler için de temel bir ihtiyaç olduğu düşünüldüğünde alanda yetişmiş nitelikli öğretmen ihtiyacının önemi de ortaya çıkmaktadır. Bu çalışmada Türkiye'de geçici koruma kapsamında olan Suriyeliler’in en yoğun olarak bulundukları illerin Halk Eğitim Merkezlerinde açılan Türkçe kurslarında görev yapan öğretmenlerin kullandıkları öğretim programları, ders içeriği belirleme ilkeleri, yöntem ve teknikler, araç gereçler, ölçme değerlendirme için kullandıkları soru tipleri, alanındaki gelişmeleri takip ettikleri kaynaklar araştırılmaktadır. Elde edilen veriler, alanda nitelikli öğretmen ihtiyacının olduğunu göstermektedir.
Прелімінарна матриця соцреалістичної парадигми «дитя революції»
Authors: Vilchanska Yulia , Zavydovych Victoria
Published: April 2020

Досліджується питання соціального вигнанства дитини (сирітства / безпритульності) в його онтологiчному значенні. Розглядається особливості формування виокремленої парадигми «дитя революції». Образ знедоленої дитини – інтерпретується, як перше втілення даної парадигми в літературі. Прослідковується специфіка формуванння парадигми «дитя революції», та вплив на це явище суспільно-історичних потрясінь. Вивчається прелімінарна кризова передісторія дитячої особистості в умовах революції як соціальної травми. Смерть дитини, піднесеної спільною справою (або захопленою новою державною ідеєю), інтерпретується як транзитивний образ європейської повоєнної літератури нового часу.
Сукупність концептів художнього дискурсу безґрунтя в українській та польській еміграційній літературі
Authors: Tsyts Halyna , Matsko Vitaliі
Published: April 2020

У статті автори уперше запропонували власне оновлений науковий погляд щодо концептуального аналізу художнього дискурсу безґрунтя в сучасному українському літературознавстві на підставі історико-літературного, філософського, демографічного, політичного, культурно-історичного, компаративного чинників. Доведено, що художній дискурс безґрунтянства є домінантною категорією і для фікційної, й для нефікційної української та польської діаспорної літератури ХХ століття. У історико-літературній, філософській основі безґрунтя закладено концептуальну дефініцію «нація» (українця чи поляка), що вказує на конкретний національний вимір буття особистості на чужині.