bluuebunny/crossref_metadata_2025 huggingface dataset:
Kajian Sustainable Development pada Kampung Wisata di Pontianak
Authors: Mislah Mislah , Utomo Rachmat Karno , Alfatmawati Laili Filda , Roshayanti Fenny
Published: August 2024

Kampung Wisata Caping Pontianak berpotensi besar sebagai tujuan wisata unggulan, tetapi masih terdapat berbagai tantangan dalam mengimplementasikan prinsip-prinsip pembangunan berkelanjutan. Penelitian ini bertujuan mengkaji implementasi pembangunan berkelanjutan di Kampung Wisata Caping Pontianak dengan fokus pada tantangan, peluang, serta dampak sosial, ekonomi, lingkungan. Penelitian ini menggunakan pendekatan deskriptif dan kualitatif, dengan metode purposive sampling untuk memilih enam partisipan. Teknik pengumpulan data berupa wawancara mendalam, observasi, dan pengumpulan dokumen. Hasil penelitian menunjukkan bahwa ada empat tantangan pembangunan berkelanjutan di Kampung Wisata Caping Pontianak yaitu sumber keuangan terbatas, kurangnya SDM potensial, promosi terbatas, dan pemesanan paket wisata di muka. Namun, ada tiga peluang :  potensi wisata budaya, alam, dan buatan; keterlibatan aktif masyarakat; dan dukungan pemerintah dan lembaga non pemerintah. Dampak  sosial : peningkatan kesadaran masyarakat akan pentingnya pelestarian budaya, kebersihan lingkungan, dan pengelolaan sampah. Dampak ekonomi : tercipta lapangan kerja baru dan memberikan sumber pendapatan tambahan. Dampak lingkungan : lingkungan yang lebih bersih, indah dan berwarna
Load Dependency of Ventricular Pump Function: Impact on the Non-Invasive Evaluation of the Severity and the Prognostic Relevance of Myocardial Dysfunction
Authors: Dandel Michael
Published: August 2024

Ventricular pump function, which is determined by myocyte contractility, preload and afterload, and, additionally, also significantly influenced by heart rhythm, synchrony of intraventricular contraction and ventricular interdependence, explains the difficulties in establishing the contribution of myocardial contractile dysfunction to the development and progression of heart failure. Estimating myocardial contractility is one of the most difficult challenges because the most commonly used clinical measurements of cardiac performance cannot differentiate contractility changes from alterations in ventricular loading conditions. Under both physiological and pathological conditions, there is also a permanent complex interaction between myocardial contractility, ventricular anatomy and hemodynamic loading conditions. All this explains why no single parameter can alone reveal the real picture of ventricular dysfunction. Over time there has been increasing recognition that a load-independent contractility parameter cannot truly exist, because loading itself changes the myofilament force-generating capacity. Because the use of a single parameter is inadequate, it is necessary to perform multiparametric evaluations and also apply integrative approaches using parameter combinations which include details about ventricular loading conditions. This is particularly important for evaluating the highly afterload-sensitive right ventricular function. In this regard, the existence of certain reluctance particularly to the implementation of non-invasively obtainable parameter combinations in the routine clinical praxis should be reconsidered in the future. Among the non-invasive approaches used to evaluate ventricular function in connection with its current loading conditions, assessment of the relationship between ventricular contraction (e.g., myocardial displacement or deformation) and pressure overload, or the relationship between ejection volume (or ejection velocity) and pressure overload, as well as the relationship between ventricular dilation and pressure overload, were found useful for therapeutic decision-making. In the future, it will be unavoidable to take the load dependency of ventricular function much more into consideration. A solid basis for achieving this goal will be obtainable by intensifying the clinical research necessary to provide more evidence for the practical importance of this largely unsolved problem.
Evaluation of User Costs in Terms of Public Transportation Fare: A Literature Review
Authors:   Department of Civil Engineering, Bogazici University, Istanbul, Türkiye, Karakurt Ahmet , Yasar Ilgin ,   Department of Civil Engineering, Bogazici University, Istanbul, Türkiye
Published: August 2024

The welfare level differs in every geography depending on the economy. This also differentiates the variables that are taken into account when determining transportation fares. While underdeveloped or developing countries determine prices by focusing only operating and investment costs, developed countries take user and environmental costs into consideration. However, the failure to describe the parameters used in determining these costs leads to the emergence of ineffective pricing policies. Especially the concept of user cost has become the focus of human-oriented policies in recent years. To this end, the paper provides a literature-based analysis of user costs using in calculation of public transportation fare. The fact that the studies in the literature did not address user costs in a clear framework has created an important gap in this regard. The aim of this study is to fill this gap in the literature by systematically examining the user cost factor affecting transportation fare and to provide a source for other research.
On the impact of emotion on decision making.
Authors: Jones Paul
Published: August 2024

This opinion paper explores the multilayered impact of emotions on decision-making and judgment, highlighting integral and incidental emotions, emotional valence, and the depth of cognitive processing. Emotions can significantly influence decisions by modifying thought content, shaping motivational goals, and affecting interpersonal interactions. These findings underscore the importance of considering emotional states in models of judgment and decision-making to enhance predictive accuracy and effectiveness.
Beyond the sum of their parts: a multi-dimensional approach to dyscalculia-dyslexia comorbidity integrating studies of the brain, behavior, and genetics
Authors: Starling-Alves Isabella , Peters Lien , Wilkey Eric D.
Published: August 2024

Dyscalculia, often referred to as mathematical learning difficulties (MD), and Dyslexia, often referred to as reading learning difficulties (RD), are specific learning disorders with independent prevalence rates estimated to be 5-10% of school-age children. However, their comorbidity (MDRD) is highly prevalent, with around 40% of children with MD also experiencing RD. Despite frequent co-occurrence, MDRD receives less attention than isolated MD and RD. As a result, the neurocognitive mechanisms of MDRD remain unclear. In the literature, three main models of MDRD have been drawn: (1) additive model, which proposes that MDRD arises from the addition of neurocognitive deficits unique to MD or RD, (2) domain-general deficit model, which proposes that MDRD stems from executive function deficits, and (3) increased-risk model, which proposes that MDRD emerges from deficits in phonological processing characteristic of RD. We review behavioral, neuroimaging, and genetic investigations of MDRD, discussing each of these models. Further, we recommend new research directions considering MDRD as a part of multiple dimensions of mathematics, reading, and domain-general skills, and highlight the importance of a holistic, functional diagnosis. A better understanding of the neurocognitive foundations of MDRD can enhance diagnosis sensitivity and specificity and facilitate tailored interventions for children with MDRD.
Declining Influence of Personality in the Later Stage of the COVID-19 Pandemic: Evidence from Nationwide Longitudinal Data from Ukraine
Authors: Soboleva Irina , Brik Tymofii
Published: August 2024

Early in the COVID-19 pandemic, scholars detected a significant association between personality traits and individual attitudes toward preventive policy measures. Policymakers were advised to take personality traits into account when designing targeted policies to curtail the spread of the virus. Few studies examined whether and to what extent personality traits predicted preventive behavior and attitudes in the later stages of the pandemic. We fill this gap using nationally representative panel data collected in Ukraine from 2019 to 2021 (1,409 unique participants). Consistent with the theory of personality coherence, we find that pre-pandemic personality traits have a better predictive capacity compared to personality traits measured during the pandemic. Personality effects are small (0.71 to 1.32 in odds ratios) and lose their predictive capacity over time, explaining about 2% of individual variability in pandemic behavior and attitudes (compared to 13% explained by individual exposure to COVID-19 in 2021). These findings advance our understanding of the role of personality in shaping responses to public health crises, suggesting that the predictive value of personality traits might be limited to the early stages of the public health crisis. Policymakers can utilize pre-pandemic personality traits to tailor policies early in the crisis while keeping in mind the limited predictive capacity and weakening effects on individual policy preferences over time.
YouTube and Veganism: A Social Media Thematic Analysis
Authors: Asadabadi Mohammad Hossein Ghaedamini , Shahreza Faezeh Dehghanzad , Sedghi Alireza
Published: August 2024

Introduction YouTube is a popular social media platform that can shape the public perception of veganism. The aims of this study included examining how veganism-related videos are depicted on YouTube and identify the possible vegan stigmas in these videos. Methods We used five keywords associated with veganism to identify the most relevant videos about veganism on YouTube (n = 1000) until May 2024 (latest upload date). Two-hundred videos were randomly selected from the initial sample of 1000 videos for further review. Two researchers independently coded the number of views, likes, comments, apparent vegan stigmas, user category and theme. Results A final sample of 183 veganism-related videos that met study criteria were included. These videos were viewed over 160 million times. Most videos showed positivity toward veganism (65.0% - 69 million views). Vegan stigmas were present in some videos (4.3%; 43 million views). The video themes were (not exclusively): ‘activism’ (41.5%; 58 million views), ‘health’ (41.5%; 42 million), ‘cooking’ (33.9%; 55 million), ‘self-concept’ (24.6%; 35 million) and ‘marketing’ (17.5%; 14 million). Conclusions Our findings indicate that vegan-related content on YouTube reaches millions of viewers. Vegan activism and heath are the main themes of these YouTube videos but some videos stigmatize vegans.
Proximate Composition and Physico-chemical Properties of Dried Pyropia acanthophora in Sta. Praxedes, Cagayan, Philippines
Authors: Rivera Ritchie , Lee Yang-Bong , Encarnacion Angel
Published: August 2024

Proximate composition and physicochemical properties to include mineral content, free amino acids, water retention capacity (WRC), and lipid adsorption capacity (LAC) of dried Pyropia acanthophora locally known as “Gamet” and endemic only in the northern Philippines were evaluated. Dried Py. acanthophora contained high amounts of crude protein (23.0±0.1%) followed by ash (16.7±0.1%), moisture (11.8±1.5%) and lipid (1.1±0.1%). Analysis of macrominerals using Inductively Coupled Plasma Optical Emission Spectrometry showed that dried Py. acanthophora have significant amounts of K, Na, Mg, P, and Ca in decreasing order. Twenty-four (24) free amino acids were also determined, and seven essential amino acids were identified including isoleucine, leucine, lysine, valine, phenylalanine, threonine, and tryptophan. A significant amount of taurine was also detected among the free amino acids. WRC of dried Py. acanthophora was determined to be 5.60 ±0.1g-H2O.g-1. LAC of dried Py. acanthophora were determined to be 2.88± 0.10g-oil.g-1, 3.30± 0.21g-oil.g-1, and 3.28±0.21g-oil.g-1 using sunflower oil, sesame oil and soybean oil, respectively. The high amounts of carbohydrate of dried Py. acanthophora determined by difference could have influenced its WRC and LAC. Based on the results of the study, Py. acanthophora should be promoted as health food and could be a potential material for the production of food supplements to meet the recommended intake of protein and other essential nutrients for humans.
THE BALKANS: DIVIDED OR SEPARATED? ANALYZING NARRATIVES OF POST-YUGOSLAV BALKAN IDENTITY
Authors:   Primakov National Research Institute of World Economy and International Relations, Russian Academy of Sciences (IMEMO), POPADEVA T.I.
Published: August 2024

The states of the former Yugoslavia and, more broadly, the Balkans today remain one of the reference points of world politics. In many ways, the Balkan Peninsula is still considered the “powder keg of Europe” due to the political division of its communities. However, the well-established toolkit for analyzing political processes in the region often reveals its predictive failure. One of the solutions in constructing trajectories for the political development of the Balkans can be an identity prism of research. In the context of the exacerbation of ethno-political conflicts after the disintegration of the SFRY, the competition of national projects and discourses of the development of newly formed polities, wars of memory and the struggle of historical narratives, economic crises and the global reorganization of the world, this paper presents a classification of post-Yugoslav states according to the nature of the politicization of social divisions that accompany identification processes in the region. Exploring the historical and political development of the Balkans and its modern narratives, the article proposes a new approach to the identity analysis of the former Yugoslavia countries - the “Center - Frontier” polarity, as well as a cognitive map of the region based on this approach.
THE POLICY OF YOUTH CIVIC IDENTITY FORMATION IN THE NEW SUBJECTS OF THE RUSSIAN FEDERATION: MODELS AND TECHNOLOGIES
Authors:   Kuban State University, SAMARKINA I.V. , BASHMAKOV I.S. ,   Kuban State University
Published: August 2024

The paper presents an analysis of models and technologies that form the civic identity of young people in the new subjects of the Russian Federation (the Republic of Crimea, Kherson and Zaporozhye regions, Donetsk and Lugansk People’s Republics). The empirical object of the study was middle and high school students representing these regions. The methodology of the empirical study of schoolchildren’s civic identity formation is based on a combination of focus group research and expert survey. In the course of our research, we analyzed the opinions of experts representing various sectors of the education and youth policy system, state institutions, public organizations, and movements in the new constituent entities of Russia. These opinions pertained to the activities of youth policy institutions, the education system, the cultural system, and civil society actors (public organizations and movements, mass media, and political parties). Our objective was to ascertain the role of these institutions and actors in the formation of civic identity. Consequently, have we identified a complex of technologies for the policy of civic identity formation of school-age youth in the new subjects of the Russian Federation. These include the subjects of identity formation, the methods and forms of translation, the degree of novelty, the functions, and the content component of the civic identity that is formed. Furthermore, we have identified the specific empirical forms (convergent and divergent) and the practices of implementing this model in the new subjects of the Russian Federation. It is shown that the fundamental differentiating factor of the aforementioned empirical models of forming schoolchildren’s civic identity in the new subjects is the sociocultural factor, which is conditioned by the influence of the system of political socialization. It is evident that the current state and formats of implementing the policy of forming schoolchildren’s civic identity in the new territories are inadequate in their consideration of the existing differentiation of actual identities.
New species of snailfish of the genus Crystallichthys (Cottiformes: Liparidae) from the Pacific waters off Kamchatka
Authors: Chernova N.V. , Kurbanov Yu.K.
Published: August 2024

A new species of snailfish, Crystallichthys longirostris sp. nov., is described from Kronotskiy Bay, southeastern Kamchatka, from depths of 192 to 200 m. The new species differs from the three other species of the genus, C. mirabilis Jordan et Gilbert, 1898, C. cyclospilus Gilbert et Burke, 1912, and C. cameliae (Nalbant, 1965), in the unusually elongated shape of the narrow snout, the dot-like round pupil, simple (not three-lobed) teeth, and the short distance from the anus to the beginning of the anal fin (9% vs. 17–19% of standard length). The colour is pink, with clearly defined red-brown rings in an elongated oval shape. The new species is also recorded near the Northern Kuril Islands at a depth of 309 m. The diagnosis of the genus Crystallichthys Jordan et Gilbert, 1898 is emended considering the characters of the new species.
The Ethno-pharmaceuticals Fighting UTI-Resistant Bacteria: Synergistic Potential Exploration
Authors: Acharya Pragnya Paramita , Jal Soumya
Published: August 2024

Urinary tract infections (UTIs) are a pressing global health concern, exacerbated by the rise of antibiotic-resistant bacterial strains. Bioprospecting, involving the exploration of natural resources for therapeutic potential, offers a promising approach to tackling this challenge. Ethnopharmaceuticals, traditional medicinal practices and remedies from indigenous communities, present a valuable source for discovering novel bioactive compounds. This review comprehensively evaluates the bioprospecting of ethnopharmaceuticals and their synergistic potential against antibiotic-resistant UTIs. Drawing from existing literature, we analyze a diverse range of ethnopharmaceuticals, elucidating their mechanisms of action and experimental evidence supporting synergistic interactions. Ethno-pharmaceuticals encompass various plant-based extracts, traditional herbal remedies, and indigenous healing practices utilized across generations to manage infections. We examine the scientific evidence supporting their efficacy in treating UTIs, clarifying their bioactive components and modes of action. Integration of traditional knowledge with modern scientific methodologies is crucial to addressing contemporary health challenges. By harnessing the synergistic potential of ethno-pharmaceuticals, we can develop alternative therapies for UTIs, offering hope for improved treatment outcomes amidst antibiotic resistance.
INCREASING THE RELIABILITY OF REINFORCED CONCRETE FRAMES OF MULTISTOREY BUILDINGS
Authors:   Industrial University of Tyumen, Malyshkin Aleksandr P. , Esipov Andrei V. ,   Industrial University of Tyumen, Esipov Mixail A.
Published: August 2024

The aim of the numerical research was to develop a method to improve the reliability of multistorey buildings with monolithic reinforced concrete frames. The method was based on the analysis of the total area of possible slab destruction due to emergencies and failure of individual building elements located in different places in the plan and in height. To analyze the reliability of spatial reinforced concrete frames according to the principle of single failure of a separate load-bearing structure, we introduced the concept of failure area coefficient. It allowed us to estimate the failure effect of a load-bearing key element of the building on the total failure area of the building slabs. In spatial frame structures of multistorey buildings with reinforced concrete frame, the key elements of the structural system are columns, pylons, collars, beams and other elements that ensure the overall stability of the building. Increasing the overall reliability of the frame building suggest the introducing an additional reliability coefficient of survivability depending on the failure area factor. In addition, we proposed an algorithm for analyzing and rejection of unsuccessful structural systems of monolithic reinforced concrete frame buildings based on the evaluation of excessively high ratios of building failure area. We analyzed the structural systems on the example of two constructed multistorey residential and public buildings with monolithic reinforced concrete frames.
MODEL OF ARCHITECTURAL AND SPATIAL GUIDELINES FOR THE ADAPTATION OF PEOPLE WITH AUTISM
Authors:   Industrial University of Tyumen, Ogneva Mariia A. , Kulachkovskiy Valeriy N. ,   Industrial University of Tyumen
Published: August 2024

Current architectural environment mostly accounts for the interests of its neurotypical users, which do not correspond with the needs of people with neurodiversity. The relevance of using certain architectural solutions for autistic people is based on their sensitivity to external stimuli, as well as statistics with increased rates of autism diagnoses. After analyzing theoretical works of foreign researchers and architects, and taking into account modern architectural solutions for people with autism spectrum disorder, we developed a model of architectural and spatial guidelines. It was based on five types of interaction between the autistic person and space: sense of self in personal space; sense of self in public space; perception of space around self; sensory sense of space; and sensory overload. The model considers the relationship between the person and the space, and prioritizes approaches to autism-friendly design such as differentiation, zoning, gradation, linking the external and internal environment, and specific architectural solutions. This design approach will adapt autistic people to interact with the environment in future, and may have a positive impact on the other user groups through "the curb-cut effect" (a phenomenon when solutions aimed at transforming the living conditions of a specific vulnerable user group help society as a whole). The model can be applied as a guide in architectural design and can also be used for future theoretical research.
INFLUENCE OF IRON CONCENTRATION IN RIVER WATER ON TREATMENT TECHNOLOGY
Authors:   Industrial University of Tyumen, Zhulin Alexander G. , Belova Larisa V. ,   Industrial University of Tyumen, Semyonov Pavel A. ,   Industrial University of Tyumen
Published: August 2024

Various iron compounds in dissolved colloidal and complex forms can be found in the surface source water. Iron content in the water of the Tura depends on the time of year and changes from 0.12 to 3.8 mg/dm3. The variety of iron forms in river water depending on annual changes requires the application of relevant technologies for its elimination. Most iron compounds are removed by coagulation and, if complex compounds are present, by the use of oxidizing agents. Systematic analyses of qualitative indicators of the Tura water by the laboratory of Metelevsky water treatment plant of Metelevsky water intake made it possible to graph the dependences of iron quantitative values on water level (river flow rate), turbidity, colour, oxidation susceptibility and hydrogen pH. Since the forms of iron compounds in natural water affect the effective choice of water treatment technology for household and drinking water, the ratios of iron (II) and iron (III) in total iron in river water depending on the value of redox (Eh) and hydrogen (pH) indices were determined for different periods of the year. The results of the study showed that during water treatment it is necessary to carry out aeration with the introduction of oxidizing agent. The objectives of the study were to identify the ratio of iron (II) and iron (III) in total iron in river water for different periods of a year in terms of Eh and pH values. The ratio of iron forms in natural water is important in the choice of water treatment technology for domestic and drinking purposes. The research showed that if total iron content in the Tura water was 0.67 mg/dm3 the amount of iron (II) was 60 percent and iron (III) was 40 percent.
Reducing Prejudice through Mediated Exposure
Authors: Schiappa Edward
Published: August 2024

It is widely recognized that “representation matters” in entertainment media, but why? What do screen representations of different demographic groups, especially historically marginalized minority groups, accomplish that further the aims of diversity, equity, and inclusion? How might current theory in cognitive psychology contribute to the understanding of how film can contribute to the reduction of invidious prejudice? This article describes the past, present, and future of the parasocial contact hypothesis (PCH). I begin by identifying important antecedents of the PCH, including early film effects research and later studies on television's cultivation effects. Then, after briefly explicating the contact hypothesis, also known as intergroup contact theory, I explicate the core tenets of the PCH, describe some of the research that has emerged in support of the PCH, and end by suggesting ways in which future research can explore when and how film and other media can reduce prejudice.
Understanding Colonialism and Identity Categories by Building on Cognitive and Affective Science
Authors: Hogan Patrick Colm
Published: August 2024

Complex, historical events such as the Nigerian Civil War emerge from countless, partially converging causes. In order to make cognitive and emotional sense of such events, novelists, filmmakers, and other storytellers stress a limited number of such causes. One central source of the antagonisms driving the Nigerian Civil War was the operation of sub-national identity categorization. Adichie (in the original novel) and Bandele (in his film adaptation) both treat such categorization, but it is more systematically and consistently developed by the latter. This is closely connected with some of the key changes that Bandele undertakes in his adaptation. After a discussion of identity categorization, ethnocentrism, racism, and “tribalism,” this article examines three key sections of the film in relation to identity categorization and their associated, political implications.
DESEMPENHO DE CULTIVARES DE FEIJÃO-CAUPI SOB APLICAÇÃO FOLIAR DE SILÍCIO NO CERRADO PIAUIENSE
Authors: Dos Santos Graziela Pereira , Avelino Gabriella Guedes , Silva Fabiano de Oliveira , Leite Wallace de Sousa
Published: August 2024

As plantas estão sujeitas a estresses abióticos a qualquer momento, e estes afetam negativamente o crescimento e a produção de espécies de interesse agronômico, como o feijão-caupi. Neste contexto, o Silício (Si) surge como uma alternativa estratégica de manejo visando melhorar o desempenho das plantas em condições adequadas de cultivo, e principalmente, sob condições com restrições, devido a sua atuação potencializadora no desenvolvimento das plantas. No entanto, estudos em campo sob sequeiro que englobem elementos minerais benéficos no feijão-caupi ainda são incipientes. Nesse sentido, o objetivo do estudo foi avaliar a ação de diferentes doses de silício nos parâmetros de crescimento e produtividade de grãos de duas cultivares do feijão-caupi.  O estudo foi conduzido em campo sob condições de sequeiro, na Fazenda Experimental do IFPI- campus Uruçuí, no delineamento experimental de blocos ao acaso com quatro repetições, em esquema de parcelas subsubdivididas 2 x 4, as parcelas correspondendo as duas cultivares de feijão-caupi (BRS Novaera e BRS Tumucumaque) e as subparcelas constituídas por quatro doses de Si (0, 5, 10, 20 g ha-1). Foram avaliados os seguintes caracteres: altura da planta, massa seca da parte aérea, número de vagens por planta, número de grãos por vagem, massa de 100 grãos e a produtividade média de grãos. A aplicação de silício influenciou positivamente a altura de plantas e a produtividade média das cultivares. A cultivar BRS Tumucumaque apresentou um incremento de 59,97% na produtividade de grãos quando o Si foi fornecido na dose de 10 g ha-1, e a BRS Novaera teve um melhor comportamento quanto a produtividade de grãos na dose de 20 g ha-1, com incremento de 46,93%. Conclui-se que a suplementação com silício é uma estratégia promissora para melhorar o desempenho agronômico do feijão-caupi.
Concurrent multiple cerebral cavernous malformations and cauda equina paraganglioma: illustrative case
Authors: Liu Daniel , Rodriguez Michael , Ross Dominic , Ghahreman Ali
Published: August 2024

BACKGROUND

Cauda equina neuroendocrine tumors (CENETs), previously known as cauda equina paragangliomas, and multiple cerebral cavernous malformations (CCMs) are uncommon conditions affecting the central nervous system. To the authors’ knowledge, they have not been reported in the same patient.

OBSERVATIONS

The authors present the case of a 45-year-old male with CENET and concurrent incidental MRI findings of multiple CCMs. Familial CCMs are associated with mutations in the KRIT1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3) genes. Peripheral paragangliomas have been associated with mutations in succinate dehydrogenase (SDHx), RET (multiple endocrine neoplasia 2), VHL (von Hippel–Lindau syndrome), and NF1 (neurofibromatosis type 1) genes. Except for a single case, cauda equina paragangliomas have not been associated with any underlying genetic mutations.

LESSONS

It is unclear whether the co-occurrence of these two rare conditions in the same patient is coincidental or suggests a possible shared pathogenesis.

https://thejns.org/doi/10.3171/CASE24102
Surgical management of a temporal meningoencephalocele with a patient-specific combined craniofossa prosthesis: illustrative case
Authors: De Moor Alexander , Willaert Robin , Sun Yi , Hunin Zoé , van Loon Johannes , Decramer Thomas , Bila Michel
Published: August 2024

BACKGROUND

Meningoencephaloceles can originate through any defect in the cranial bones, including the skull base. They can be completely asymptomatic or present with typical symptoms such as headaches, seizures, or meningitis.

OBSERVATIONS

The authors present the case of a 54-year-old female who presented with right-sided ear and temporomandibular joint (TMJ) pain. Computed tomography showed a large lytic lesion of the squamous part of the temporal bone with cortical bone destruction, extending to the mandibular fossa. Magnetic resonance imaging demonstrated a temporal bone meningoencephalocele. The patient underwent resection, dural repair, and multilayer reconstruction with a patient-specific three-dimensional–printed titanium combined craniofossa prosthesis.

LESSONS

To the authors’ knowledge, this is the first case report of TMJ pain associated with a temporal meningoencephalocele. The exact location and extension of the lesion determine the surgical approach and need for reconstruction in temporal bone meningoencephaloceles. In cases of destruction of the mandibular fossa, a patient-specific combined craniofossa prosthesis is recommended to reconstruct the bone defect.

https://thejns.org/doi/10.3171/CASE24132
Neurological outcomes of flow-diverter stent placement for middle cerebral artery aneurysms, with reference to the effects of argatroban on ischemic events: patient series
Authors: Yoshida Shinichiro , Kazekawa Kiyoshi , Kamatani Kaisei , Maruyama Kousei , Takigawa Kousuke , Tashiro Noriaki , Hashiguchi Yoshiya , Yasaka Masahiro , Aikawa Hiroshi , Go Yoshinori
Published: August 2024

BACKGROUND

A systematic review and meta-analysis of flow-diverter stents (FDSs) for the treatment of middle cerebral artery (MCA) aneurysms reported concerns about ischemic complications during treatment. The authors report on the intraoperative and postoperative complications of unruptured MCA aneurysms and their control strategies at their hospital, with detailed information on the aneurysms and a review of the previous literature.

OBSERVATIONS

Intraoperative and perioperative in-stent thrombus occlusion occurred in 3 (37.5%) of the 8 patients evaluated. In cases with in-stent thrombus formation, rapid administration of 10 mg argatroban led to improvement in blood flow, as seen on angiography. Only 1 patient (12.5%) had a symptomatic stroke postoperatively. This patient was admitted for rehabilitation and drug therapy but was discharged from the hospital 10 days postoperatively with a modified Rankin Scale (mRS) score of 1. The patient had an mRS score of 0 at 90 days after surgery and at the last observation.

LESSONS

Ischemic complications require attention during FDS treatment for MCA aneurysms. The use of argatroban in cases of in-stent thrombosis may contribute to a good neurological prognosis.

https://thejns.org/doi/10.3171/CASE24237
Emulgel Towards Novel Formulation Development: A Comprehensive Review
Authors: Ganju Eisha , Deshmukh Susheel , Gupta Bhaskar Kumar
Published: August 2024

Emulgels are an innovative topical drug delivery system that combines the properties of emulsions and gels to enhance the delivery and efficacy of pharmaceuticals. These systems leverage the advantages of both components: the solubilizing capabilities of emulsions and the stable, bioadhesive properties of gels. This review aims to summarize the development, formulation strategies, evaluation techniques, and therapeutic applications of emulgels. A comprehensive literature search was conducted across various scientific databases including PubMed, Scopus, and Web of Science. Studies focusing on the formulation, characterization, and clinical efficacy of emulgels were included. The review evaluates the methodologies used in the preparation of emulgels, including the choice of gelling agents, emulsifiers, and active pharmaceutical ingredients (APIs). Analytical techniques for assessing the physicochemical properties and stability of emulgels were also examined. The review identified key formulation parameters that influence the performance of emulgels, such as the type and concentration of gelling agents (e.g., carbomers, xanthan gum), emulsifiers (e.g., Tween, Span), and oils. Optimization of these components significantly affects the viscosity, spreadability, and drug release profile of emulgels. Studies demonstrated that emulgels exhibit improved drug penetration and sustained release compared to conventional topical formulations. Therapeutic applications of emulgels encompass a wide range of conditions including dermatological disorders, pain management, and microbial infections. The review also highlights novel advancements such as the incorporation of nanoparticles and the development of stimuli-responsive emulgels. Emulgels represent a promising platform for topical drug delivery, offering enhanced stability, bioavailability, and patient compliance. The versatility in their formulation allows for the incorporation of diverse APIs, making them suitable for various therapeutic areas. Future research should focus on the clinical translation of emulgels, exploring their potential in personalized medicine, and addressing regulatory challenges. Emulgels have the potential to revolutionize topical therapy and provide new avenues for effective and targeted drug delivery.
Determination of local expressions of IGF-1, LC3B and NF-kB in white muscle disease in lambs by immunohistochemical method
Authors: Akçakavak Gökhan , Karataş Özhan , Tural Ayşenur , Dağar Osman , Doğan Osman , Tuzcu Mehmet
Published: August 2024

White muscle disease (WMD) is also known as Stiff Lamb Disease or Nutritional Muscular Dystrophy. Selenium and/or Vitamin E deficiency constitutes the etiology of the disease. This study aimed to immunohistochemically evaluate local protein expressions of Nuclear factor kappa B (NF-kB), Insulin-like growth factor-1 (IGF-1) and Microtubule-related protein 1A/1B-light chain 3 beta (LC3B) in WMD. The material of the study consisted of 15 WMD, and 6 healthy lamb heart samples. The heart tissues of the autopsied lambs were subjected to routine tissue processing and paraffin blocks were obtained. Then, it was stained with Hematoxylin-Eosin and immunohistochemical methods. Control group lambs had normal macroscopic appearance. Macroscopically, hyaline degeneration and zenker’s necrosis, calcification areas were observed in WMD tissues. Microscopically, degenerative and necrotic muscle fibers, calcification areas, fibrosis, mononuclear cell infiltrates and macrophage infiltrates were detected in WMD heart tissues. Immunohistochemically, significant increases were detected in IGF-1 (p
Model of Orthodox Upbringing as the Basis for Preserving Traditional Values in Russia
Authors: Медведев Сергей
Published: August 2024

В статье обозначена проблема развития системы отечественного образования через сохранение традиционных ценностей русского народа и преемственности поколений. Отмечается, что в России, на протяжении столетий, традиционные ценности формировались на основе Православного вероучения. Выделяются три группы ценностей, традиционных для православного сознания. Отмечается, что усвоение ценностной парадигмы учащимися возможно через реализацию православной модели воспитания, в основе которой лежит христианское представление о человеке, смысле его бытия и предназначении. В статье рассматривается структура модели воспитания на основе православной традиции, приводятся основные цели и принципы, формы, методы, средства обучения и воспитания, критерии, соответствующие показателям, по которым можно судить об уровне сформированности ценностных ориентиров личности в условиях образовательных организаций с религиозным (православным) компонентом.

The article identifies the problem of developing the national education system through the preservation of the traditional values of the Russian people and the continuity of generations. It is noted that in Russia, over the centuries, traditional values were formed on the basis of the Orthodox faith. Three groups of values traditional for the Orthodox consciousness are identified. It is noted that students’ assimilation of the value paradigm is possible through the implementation of the Orthodox model of upbringing, which is based on the Christian concept of man, the meaning of his being and purpose. The article examines the structure of an upbringing model based on the Orthodox tradition, provides the main goals and principles, forms, methods, means of teaching and education, criteria corresponding to indicators by which one can judge the level of formation of a person’s value orientations. in educational organizations with a religious (Orthodox) component.
ВИКОРИСТАННЯ ІНСТРУМЕНТІВ КРЕАТИВНОГО МЕНЕДЖМЕНТУ ДЛЯ УПРАВЛІННЯ ПЕРСОНАЛОМ ОРГАНІЗАЦІЙ
Authors: БІЛИК Вікторія , ФІМЯР Світлана , ЧЕН Наталія
Published: August 2024

У ході написання статті ретельно розглянуто теоретичні аспекти та загальну концепцію креативного менеджменту та його значення для сучасних організаціях, особливо в контексті нестабільного економічного середовища та необхідності інноваційного розвитку. Стаття систематизує важливість інтеграції креативного менеджменту в управлінські практики підприємств, аргументуючи його роль у підтримці конкурентоспроможності та стабільності бізнесу. Під час проведення дослідження було детально проаналізовано наявні інструменти креативного менеджменту, які застосовуються для ефективного управління персоналом на сучасних організаціях. Визначено, що використання цих інструментів дозволяє організаціям забезпечити необхідний рівень гнучкості та адаптивності в управлінні завданнями та проєктами. Здійснено узагальнення основних переваг цифрових платформ у контексті структурування робочих процесів та інтеграції інших інструментів для обміну ідеями. Також систематизовано різновиди платформ для покращення комунікації та співпраці серед персоналу, що сприяє ефективному обміну інформацією та оперативному вирішенню завдань. Особлива увага була приділена інструментам для управління талантами, що сприяють створенню стимулюючого середовища та підтримці кар'єрного зростання співробітників. Крім того, охарактеризовано платформи для організації навчання та розвитку персоналу, які сприяють розвитку креативного мислення та підвищенню мотивації працівників. На основі результатів дослідження були сформульовані рекомендації щодо впровадження цих інструментів з метою зміцнення конкурентоспроможності організацій та підтримки їхнього інноваційного розвитку.
Bridging Gaps in Opioid Use Disorder Treatment: Prehospital and Emergency Department Interventions
Authors:   Rowan University, Buob Quin W. , Noll Zachary J.
Published: August 2024

Since 2011, drug overdose has been the leading cause of accidental death in the United States, with two-thirds of these deaths related to opioid drugs. In 2020, the CDC reported an increase of over 91,000 overdose-related deaths. Also, non-fatal overdoses face a 5.5% one-year mortality rate post discharge, with a significant portion subsequently overdosing within 48 hours. Access to Buprenorphine/Medication-Assisted Treatment (MAT) has been instrumental in reducing opioid-related mortality by over two-thirds, yet treatment initiation remains significantly low. Limited access stems from socioeconomic disparities and insufficient substance use treatment resources. Emergency departments (EDs) have pioneered Buprenorphine inductions, showcasing variable success depending on post-ED support availability. Prehospital Buprenorphine administration, initiated across the country, aims to bridge the gap between prehospital care and traditional substance abuse treatment, enhancing treatment retention and patient engagement. Studies highlight successful ED Buprenorphine inductions and subsequent linkage to long-term care, utilizing various strategies such as MAT prescriptions, Clinical Decision Units, and direct referrals to treatment centers. Despite retention to treatment, concerns arise regarding declining long-term retention and smaller sample sizes affecting outcomes. Unexpectedly, these interventions have led to increased physician interest in Buprenorphine waiver applications and heightened ED encounters for substance use disorders. Notably, resident physicians have shown more engagement compared to attending physicians in out-of-hospital Buprenorphine prescriptions. The review shows efforts in improving opioid use disorder treatment by leveraging prehospital and ED interventions, addressing access barriers, improving retention rates, and fostering physician engagement.
Brain Connectivity Pattern Changes Associated With Psychedelic-Assisted Psychotherapy
Authors:   Rowan University, Patel Prince , Gollapudi Samrat , Mathew Brian Joseph , Patel Bhaumik
Published: August 2024

Psychedelic-assisted psychotherapy (PAP) has shown promising therapeutic benefits for various psychiatric disorders, but the underlying neural mechanisms remain unclear. This study aimed to investigate the effects of psychedelics on brain connectivity patterns using functional magnetic resonance imaging (fMRI). A comprehensive literature search was conducted in PubMed and Google Scholar databases using relevant keywords related to psychedelics, connectivity, therapy, and fMRI. Only studies involving major psychedelic compounds (LSD, psilocybin, ayahuasca) and measuring outcomes via fMRI were included. The findings from the reviewed studies suggest that psychedelics induce acute disruptions in normal large-scale brain network patterns, leading to a compromised modular but enhanced global connectivity, referred to as network "disintegration" and "desegregation." This "internal" brain state correlates with aspects of the psychedelic experience, such as ego dissolution. Post-acute effects, one day after psilocybin treatment, revealed changes in cerebral blood flow and resting-state functional connectivity compared to baseline, including increased default mode network (DMN) integrity and functional connectivity within the DMN. The proposed therapeutic mechanisms of PAP involve the synergistic combination of the psychedelic substance and the accompanying psychotherapy. Further research is warranted to delineate the specific brain connectivity changes associated with different psychedelic compounds and their relationship to therapeutic outcomes in various psychiatric conditions.
BRASH Syndrome: A Deadly Pentad of Symptoms
Authors: Killian Peter , Kandil Adam
Published: August 2024

Here we present the case of a male in his 70’s who presented with diarrhea and a syncopal episode and was ultimately diagnosed with BRASH syndrome. The acronym BRASH is a novel way to describe the constellation of symptoms that result in unfortunate synergistic affects that can result in profound bradycardia. In the setting of hyperkalemia and concurrent use of atrioventricular nodal blockers, there is potential for a worsening bradycardia and inevitable cardiovascular collapse if not identified.
Encuesta de percepción sobre riesgos del sistema Financiero - Junio de 2024
Authors:   Departamento de Estabilidad Financiera
Published: August 2024

En este informe se presentan los resultados de la Encuesta de Percepción Sobre Riesgos del Sistema Financiero, la cual busca identificar la perspectiva de diferentes agentes de la economía frente a los riesgos y vulnerabilidades más importantes que enfrenta el sector financiero, y evaluar cuál es el nivel de confianza que tienen en su estabilidad.
Enki’s Seven Sages (Adapa/Oannes and the Apkallu): Humanity’s Cosmic Guardians
Authors: Bondzhev Asen
Published: August 2024

In contrast to the cruel and militant gods, who treated humans as pawns in their power struggle, Enki is remembered not just as a benevolent god who saved the human race from extermination, but who also imparted knowledge. Especially scholarly disciplines like divination, astrology, astronomy, lamentation and exorcism were considered a revelation by Enki. The Catalogue of Texts and Authors attests that a handbook of medical symptoms comes “of the mouth of Ea”, “Adapa wrote them down at his dictation.” Enki was helped by his Seven Sages – the apkallu (Adapa being the main one) – the cosmic guardians who disseminated his knowledge, and were remembered as teachers of humankind and laying the foundation of civilization. According to Berossus, “from that time nothing further has been discovered.” Sometime around the Flood they disappeared, descending to the abode of Enki. This transition is reflected in the change from semi-divine sages or culture-heroes (apkallu) to scholars (ummanu).
Anerkennung und Validierung. Stichwort
Authors:   Deutsches Institut für Erwachsenenbildung (DIE), Annen Silvia
Published: August 2024

Anerkennungs- und Validierungsverfahren haben in Deutschland insbesondere vor dem Hintergrund der Arbeitsmarktintegration von Migranten, der beruflichen Weiterbildung sowie der Förderung lebenslangen Lernens eine zunehmende Bedeutung erlangt. Gesetze, nationale Rahmenwerke und Netzwerke fördern die Anerkennung und Validierung auf verschiedenen Ebenen. Die entsprechenden Verfahren spielen eine entscheidende Rolle bei der Bewältigung aktueller Herausforderungen im Bildungsbereich sowie auf dem Arbeitsmarkt.
Qualifizierungsmaßnahmen: Ein Schlüssel zur Beschleunigung. Anerkennung ausländischer Berufsqualifikationen in Deutschland
Authors: Böse Carolin , Atanassov Rebecca
Published: August 2024

Die Anerkennung ausländischer Abschlüsse ist ein wichtiger Aspekt für die qualifikationsadäquate Beschäftigung ausländischer Fachkräfte. Am Beispiel der Pflegeberufe zeigen die Autorinnen, wie bedeutend Qualifizierungsmaßnahmen für den Anerkennungsprozess sind und welche Rolle Weiterbildungsanbieter dabei spielen.
Effizienter anerkennen mit Kompetenzfeststellung und KI. Einblick
Authors: Krahl Diana , Roser Laura
Published: August 2024

Effizienter anerkennen mit Kompetenzfeststellung und KI - mit diesem Thema beschäftig sich der Artikel und vor dem Hintergrund beleuchtete eine vom Bundesministerium für Bildung und Forschung geförderte Machbarkeitsstudie des Forschungsinstituts Betriebliche Bildung (f-bb), inwiefern Prozesse der Beratung, Gleichwertigkeitsprüfung und (Teil-)Qualifizierung stärker verknüpft und weiterentwickelt werden können.