bluuebunny/crossref_metadata_2025 huggingface dataset:
Enrique III De Castilla (1390-1406) y la indagación de rentas: un proyecto regio para la búsqueda de mineros y tesoros a inicios del cuatrocientos
Authors: Nogales Rincón David
Published: July 2021

La noción de tributo justo, convertida en concepto clave del pensamiento fiscal bajomedieval, hubo de marcar la orientación de la política hacendística de los nacientes Estados monárquicos, como sugiere una iniciativa desarrollada por la realeza castellana en el tránsito de los siglos XIV al XV, basada en el proyecto de consecución de nuevas rentas a través de la búsqueda de minas y tesoros. Para ello, se parte de tres documentos del Archivo General de Simancas, que, aunque carecen de fecha, cabría situar hipotéticamente durante el reinado de Enrique III de Castilla (1390-1406), los cuales son contextualizados en el marco de la política fiscal de la monarquía castellana y de las líneas de acción política del tercer Trastámara. El estudio permite sugerir el interés de Enrique III por impulsar nuevas fuentes de renta, más allá del incremento de los tributos, como garantía de una actuación acorde al ideal regio bajomedieval.
Apostilla al estudio influencia de las redes nobiliarias en la expansión cristiana del siglo XII: el caso de Soria (ETF, 33, 2020)
Authors: Olcoz Yanguas Serafín
Published: July 2021

Tras la lectura de un trabajo sobre los primeros tenentes de Soria, publicado en esta misma revista (ETF, 33, 2020), procedemos a corregir algunos de sus errores y a añadir algunas novedades sobre dichos nobles personajes, sus vínculos familiares y la influencia de éstos en la nueva Extremadura entre los reinos de Pamplona y Aragón, y de Castilla, así como sus relaciones con las Órdenes Militares y las cofradías seglares vinculadas a éstas, que también fueron clave en la evolución de dicho proceso.
Hacia una revalorización del conciliarismo hispano bajomedieval: el defensorium trium conclusionum de Alfonso de Madrigal
Authors: Morales Muñoz Raúl
Published: July 2021

Este trabajo busca poner de manifiesto la existencia y, sobre todo, la relevancia de los autores hispanos que se decantaron por las teorías conciliaristas durante la crisis que sacudió a la Iglesia en la Baja Edad Media. Estos autores hispanos conciliaristas, aunque no son muy numerosos, gozan de una gran originalidad y sus doctrinas poseen un elevado interés eclesiológico. Ejemplificaremos nuestras afirmaciones mediante el Defensorium Trium Conclusionum, obra de Alfonso de Madrigal el Tostado en la que este expone su pensamiento conciliarista, pensamiento que está formulado con una claridad, un rigor metodológico y una fidelidad a la propia idea conciliarista ausentes en muchos de los autores europeos, incluso en aquellos que habitualmente son considerados firmes defensores del conciliarismo.
Aportaciones de Paredes de Nava a las campañas militares del Infante Don Fernando, señor de la villa y regente de Castilla, contra el Reino Nazarí de Granada en 1407 y en 1410
Authors: González Sánchez Santiago
Published: July 2021

Este artículo estudia las aportaciones que la villa de Paredes de Nava (Palencia) hizo a las campañas militares del infante don Fernando, el de Antequera, señor de la villa y regente de Castilla, contra el reino nazarí de Granada en 1407 y, sobre todo, en 1410. Se presta especial atención a esta última, pues es de la que tenemos más documentación. En tal sentido se analizan la elección de los combatientes –principal contribución de la villa en 1410–, su permanencia en la campaña o su conducta, pasando por el posible momento de su salida y el itinerario seguido. Se abordan los aspectos hacendístico-fiscales que conllevaba la movilización y el desplazamiento de tan importante contingente de combatientes y sus repercusiones en la hacienda de Paredes de Nava: imposición de tributos extraordinarios, posibles préstamos y disminución de ingresos. También se tratan de forma breve las informaciones que llegaban a Paredes sobre la evolución de la guerra y los gastos que el concejo hizo en festejos para celebrar la victoria castellana.
Reseña de: Castrillo Casado, Janire, Las mujeres vascas durante la Baja Edad Media
Authors: Fuente María Jesús
Published: July 2021

Reseña de: Castrillo Casado, Janire, Las mujeres vascas durante la Baja Edad Media, Madrid, Sílex, 2020, 398 pp. ISBN: 978-84-7737-551-7.
Manufacturing USA Institute evaluation :
Authors:   Office of Advanced Manufacturing
Published: July 2021

The Manufacturing USA Program's 2019 reauthorization allows the National Institute of Standards and Technology (NIST) to renew Manufacturing USA institute support, subject to a rigorous merit review. Following an initial five to seven-year cooperative agreement in which federal support must be cost-matched by at least a 1:1 match of non-federal co-investment over the performance period of the award, NIST-funded institutes are now eligible to apply for renewal of their support. This document describes the institute renewal process, with a focus on the performance standards for the merit review.
Przegląd ekonomiczno-przestrzennych badań rynku samochodów osobowych = A review of economic and spatial research on the market for passenger cars
Authors: Stryjakiewicz Tadeusz , Kołsut Bartłomiej , Doszczeczko Bartosz , Dyba Wojciech , Kisiała Wojciech , Kudłak Robert , Wojtyra Bartosz
Published: July 2021

Rynek samochodów osobowych – ze względu na skalę, dynamikę i konsekwencje jego rozwoju – staje się w coraz większym zakresie przedmiotem badań wielu dyscyplin naukowych, w tym geografii. Przemiany tego rynku są uzależnione w szczególności od dochodów i preferencji mieszkańców, polityki państw i organizacji międzynarodowych oraz poziomu rozwoju gospodarek, w szczególności rozwoju przemysłu motoryzacyjnego. Z drugiej strony, wielkość oraz struktura rynku samochodów osobowych w istotny sposób wpływają na poziom PKB wielu państw rozwiniętych, na eksport samochodów używanych do krajów peryferyjnych oraz na jakość środowiska przyrodniczego. Wpływ ten zaznacza się również na poziomie regionalnym i lokalnym (np. kwestia dostępności przestrzennej dóbr i usług). Dlatego w badania rynku samochodów osobowych włączają się coraz częściej specjaliści zajmujący się geografią ekonomiczną oraz geografią rozwoju regionalnego. Celem artykułu jest przedstawienie wybranych kierunków, a także wyników badań rynku samochodów osobowych, ze szczególnym wyeksponowaniem ich wymiaru geograficznego. Koncentrują się one wokół czterech głównych grup zagadnień: (1) poziomu motoryzacji i modelowania popytu na samochody, (2) relacji między rynkiem aut nowych i używanych w krajach rozwijających się, (3) roli czynników przestrzennych i transportu publicznego w funkcjonowaniu rynku samochodowego oraz (4) skutków środowiskowych upowszechnienia motoryzacji i sposobów ich ograniczania, takich jak elektromobilność oraz ekonomia współdzielenia.
Le chamanisme shipibo à l’épreuve de la modernité
Authors: Slaghenauffi Doriane
Published: July 2021

Le chamanisme shipibo (Amazonie péruvienne) exerce aujourd’hui un attrait tout particulier pour une clientèle nouvel âge occidentale en quête d’expériences hallucinogènes — ce qui, à première vue, serait à l’origine d’une certaine forme d’acculturation de l’institution « traditionnelle ». Or, l’analyse de la cure thérapeutique réservée aux touristes occidentaux, de même que les dispositifs de traduction et d’appropriation de composantes modernes telles que la médecine allopathique, semblerait plutôt mettre en relief une certaine forme de résilience, de la part des chamanes shipibo, par le biais de la mise en avant du règne végétal dans les thérapies. En effet, les plantes utilisées seraient capables d’« indigéniser » le corps du patient occidental dans un but curatif, mais aussi afin de faire subir au touriste une forme de socialisation par les plantes. Une telle action constituerait une réponse aux bouleversements que connaît aujourd’hui la société shipibo dans le contexte de la globalisation.
Vertimus
Authors: Marder Michael , Kerbiriou Anne-Hélène , Fortin Dominique
Published: July 2021

En trois préambules et dix thèses, je considère la signification de « devenir-plante » en approfondissant le sens du devenir, de la végétalité et de leur imbrication mutuelle. Ces réflexions tournent, par ailleurs, autour de la figure de rotation dénotée dans le verbe latin vertere, même si elles remontent à la pensée grecque antique du devenir selon les voies parallèles de la métamorphose et du métabolisme, un changement de forme spatial et un changement temporel de trajectoire. La leçon pratique et philosophique de ces thèses est qu’il n’y a pas de devenir sans l’arrondi — sinon la circularité — du tournement ; qu’il ne s’agit pas d’une ligne directe d’ici à là, mais d’une route faite de détours et de va-et-vient (de l’être et du néant, de la progression ou de la digression dans une série et dans une boucle…) ; et que se tourner en (ou avec les) plantes est se tourner en (ou avec le) tournement, en osant devenir le devenir lui-même.
The use of euphemisms in public speeches of the US politicians
Authors: Guzova Aleksandra Viktorovna
Published: July 2021

The subject of this research is the role of euphemisms in political communication. The goal of this article is to establish the functional role of euphemisms in public speeches of the US politicians based on the texts of speeches for the period 2020 – 2021. Research methodology relies on the provisions of linguorhetoric, namely the functional role of lexicon within the framework of a particular speech genre. The article employs the general scientific method, systematization and generalization, content analysis, discursive analysis, method of continuous sampling, and linguostylistic analysis. It is determined that the use of euphemisms in speeches of the IS politicians for the period 2020 – 2021 performs the following functions: manipulative, veiling the reality, self-positioning. In public speech, the important factors are politeness and delicacy for maintaining and promoting communication. It is noted that politics is the sphere that requires using a variety of euphemisms. The mechanisms of euphemization are based on the inaccuracy of speech, ambiguity, and generalized nomination of the object. Practical importance of this research consists in the fact that its results can be implemented in rhetoric courses, as well as in preparation of public speeches. The scientific novelty lies in establishment of the functional role of euphemistic nominations based on public speeches of the US politicians for 2021.
Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10
Authors: Li Jingxiang , Guo Shupan , Chai Fangni , Sun Qi , Li Pan , Gao Li , Dai Lunzhi , Ouyang Xiaoxiao , Zhou Zhihui , Zhou Li , Cheng Wei , Qi Shiqian , Lu Kefeng , Ren Haiyan
Published: July 2021

Autophagy acts as a pivotal innate immune response against infection. Some virulence effectors subvert the host autophagic machinery to escape the surveillance of autophagy. The mechanism by which pathogens interact with host autophagy remains mostly unclear. However, traditional strategies often have difficulty identifying host proteins that interact with effectors due to the weak, dynamic, and transient nature of these interactions. Here, we found that Enteropathogenic Escherichia coli (EPEC) regulates autophagosome formation in host cells dependent on effector NleE. The 26S Proteasome Regulatory Subunit 10 (PSMD10) was identified as a direct interaction partner of NleE in living cells by employing genetically incorporated crosslinkers. Pairwise chemical crosslinking revealed that NleE interacts with the N-terminus of PSMD10. We demonstrated that PSMD10 homodimerization is necessary for its interaction with ATG7 and promotion of autophagy, but not necessary for PSMD10 interaction with ATG12. Therefore, NleE-mediated PSMD10 in monomeric state attenuates host autophagosome formation. Our study reveals the mechanism through which EPEC attenuates host autophagy activity.
Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD
Authors: Burt Joshua B , Preller Katrin H , Demirtas Murat , Ji Jie Lisa , Krystal John H , Vollenweider Franz X , Anticevic Alan , Murray John D
Published: July 2021

Psychoactive drugs can transiently perturb brain physiology while preserving brain structure. The role of physiological state in shaping neural function can therefore be investigated through neuroimaging of pharmacologically induced effects. Previously, using pharmacological neuroimaging, we found that neural and experiential effects of lysergic acid diethylamide (LSD) are attributable to agonism of the serotonin-2A receptor (Preller et al., 2018). Here, we integrate brain-wide transcriptomics with biophysically based circuit modeling to simulate acute neuromodulatory effects of LSD on human cortical large-scale spatiotemporal dynamics. Our model captures the inter-areal topography of LSD-induced changes in cortical blood oxygen level-dependent (BOLD) functional connectivity. These findings suggest that serotonin-2A-mediated modulation of pyramidal-neuronal gain is a circuit mechanism through which LSD alters cortical functional topography. Individual-subject model fitting captures patterns of individual neural differences in pharmacological response related to altered states of consciousness. This work establishes a framework for linking molecular-level manipulations to systems-level functional alterations, with implications for precision medicine.
A comprehensive review of deep learning-based single image super-resolution
Authors: Bashir Syed Muhammad Arsalan , Wang Yi , Khan Mahrukh , Niu Yilong
Published: July 2021

Image super-resolution (SR) is one of the vital image processing methods that improve the resolution of an image in the field of computer vision. In the last two decades, significant progress has been made in the field of super-resolution, especially by utilizing deep learning methods. This survey is an effort to provide a detailed survey of recent progress in single-image super-resolution in the perspective of deep learning while also informing about the initial classical methods used for image super-resolution. The survey classifies the image SR methods into four categories, i.e., classical methods, supervised learning-based methods, unsupervised learning-based methods, and domain-specific SR methods. We also introduce the problem of SR to provide intuition about image quality metrics, available reference datasets, and SR challenges. Deep learning-based approaches of SR are evaluated using a reference dataset. Some of the reviewed state-of-the-art image SR methods include the enhanced deep SR network (EDSR), cycle-in-cycle GAN (CinCGAN), multiscale residual network (MSRN), meta residual dense network (Meta-RDN), recurrent back-projection network (RBPN), second-order attention network (SAN), SR feedback network (SRFBN) and the wavelet-based residual attention network (WRAN). Finally, this survey is concluded with future directions and trends in SR and open problems in SR to be addressed by the researchers.
An Archetype in Art History: Circle Form and the Eye
Authors: ERİM Gonca , ONAN Berna Coşkun
Published: July 2021

Tarih öncesi çağlardan günümüze insanoğlu, mitolojik, dini ve sosyolojik dışavurumlarında simgesel anlatımın bir yolu olarak daire formunu kullanmıştır. Uygarlık tarihinin görsel veri tabanı, daire formunun bütünleştirici, güçlü ve
kusursuz simgesel niteliğine dair birçok kayıtla doludur. İlkel dinlerde tanrısal varlığı sorgulanan güneşin dairesel görüngüsünden, gotik dönemin ikonografik öğelerine kadar daire formu, resimsel anlatılarda kutsallığın sembolü
olmuştur. Göbeklitepe gibi tapınaklarda toplulukların dairesel bir düzende bir araya gelmelerinden hareketle, benzer bir eğilimin modern dünyada kentleşmede gözlemlenen bir olgu olduğuna da değinilebilir. Özellikle Gotik dönem
eserlerinden minyatürlere kadar güçlü simgesel yapısı nedeniyle başvurulan dairesel düzenler, sosyolojik veriler barındıran önemli bir kompozisyon türü olarak görülebilir. Erken Rönesans ve Hümanizm düşüncesine paralel yaygınlaşan
tondo resimlerin daire formu, çağlar öncesinden günümüze mühür, para ve takıların daireselliğiyle ilişkisinin yanı sıra dairesel bir çerçeveden dış dünyayı algılama anlamında da görme eylemiyle, izleyenin sanatçıyla aynı duygulanıma
taşındığını da düşündürmektedir. Rönesans resimlerinde bireyselleşen dış dünya algısı, hümanizma düşüncesinin görenin gözünden ifade edilişinin de kanıtı niteliğindedir. Rönesans resimlerinde bireyselleşen dış dünya algısı, hümanizma
düşüncesinin görenin gözünden ifade edilişinin de kanıtı niteliğindedir. Sanatçıların duygu ve dışavurum anlamında güçlü sembolik arketipler taşıyan daire formunun bütünlüğünden yararlanmaları, onları bu bütünlüğü ifade etmenin
çeşitli yollarını aradıkları farklı bir sürece sürüklemiştir. Bu süreçte modernizmin çeşitli plastik çözümlemelerinde gözün yapısı ve görme eylemi irdelenmiş, felsefe ve ontoloji bağlamında temel kaygı olmaya başlamıştır. Göz,
algının başladığı nokta olmakla beraber ifadenin dairesel verilerinin iletisel gücünü ortaya koyan bilimsel bir veri ve sanatta bu gücü temsil eden bir konu olarak da değer kazanmaya başlamış, birçok sanatçı tarafından bir konu
olarak ele alınmıştır. Bu araştırmada, nitel araştırma yöntemi kullanılmış olup, araştırmanın amacı doğrultusunda literatür taranmış, dokümanlar incelenmiş ve güvenilir internet kaynaklarına ulaşılmıştır. Araştırma bağlamında,
daire formundan hareketle görme eylemi ve göz ilişkisine, sanatta bir konu ve plastik bir bağlaç olarak yaklaşılmış, kuramsal bir tartışma yürütülmek amaçlanmıştır. Bu amaçla sanat tarihinde gözü bir konu olarak ele alan sanatçıların
eserlerindeki yaklaşımlar üzerinden sunulmaya çalışmıştır.
Production and Evaluation of Breakfast Meals from Germinated and Ungerminated Blends of Sorghum and Soybean by Cold Extrusion Process
Authors: Kiin-Kabari D. B. , Obiageli Anijekwu, Prisca , Eke-Ejiofor J.
Published: July 2021

Breakfast meal was formulated from blends of sorghum and soya beans. The mixed blends of (ungerminated and germinated sorghum/soyabean flour blends) was produced into S-shaped granules using a cold extruder in the following formulation ratio of 100:0, 90:10, 80:20, 70:30,and 60:40 ratio. Proximate composition, total mineral (Magnesium, phosphorous, potassium calcium, iron and Zinc), extractable mineral and mineral bio-availability were carried out on the finished product of different blends. Germinated products showed lowest moisture(7.99 %) and carbohydrate(59.43 %) contents, and high values of Ash (3.64 %), Protein(18.19 %) and fat (8.99 %) contents. The highest value Fiber and Energy were obtained in the ungerminated products with values of 11.22 % and 355.72 %, respectively.Bioavailability of germinated product blends showed higher values for all the minerals analyzed.Onsensory evaluation, the ungerminated sorghum product (100:0) recorded highest values among the samples analyzed and was most preferred in term of colour (4.35) and taste (4.10) while the germinated products received preference in the texture with a highest value of 4.35. The overall acceptability was recorded in the ungerminated products with the highest value of 4.15. The results showed that germination and substitution with soya bean up to 60:40 increased the nutrient content of breakfast meal.
A New Class of Life Distributions Based on Moment Inequalities
Authors: Hassan E. M. A. , Said M. M.
Published: July 2021

In this paper, a new class of life distribution is named new better than renewal used in moment generating function (NBRUmgf). A new test for exponentiality versus NBRUmgf based on moment inequalities is established. Pitman's asymptotic efficiencies, powers and critical values of the new test are calculated to assess the performance of the test. The right censored data is handled also. Finally some applications are applied to the new test.
Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage
Authors: Ashraf Heba Ibrahim , El-Mashad Abd El-Rahman Mohamed , El-Sheikh Mai Rabie
Published: July 2021

Background: Preterm infants with Intra-Ventricular Hemorrhage (IVH) are at risk for developing significant complications, including post hemorrhagic hydrocephalus and seizures. Neonatal seizures are the most common overt manifestation of neurological dysfunction in the newborn, and is associated with short- and long-term adverse effects.

Objective: The aim of the study is to evaluate the value of Peripheral Neutrophil- lymphocyte ratio (NLR) as a predictor of seizure in preterm infants with intra-ventricular hemorrhage.

Methods: This prospective cohort study that comprised 60 Preterm infants with IVH admitted at NICU pediatric department Tanta university hospital from November 2019 to May 2020, Preterm infants were divided into two groups according to incidence of seizure.

Preterm infants in this study subjected to Careful history taking, clinical examination and investigations (laboratory and Trans-cranial ultrasound) as well as analysis of result and follow up clinical status for development of seizure.

Results: There was a statistically highly significant difference regarding NLR and development of seizure with p value <0.001 (NLR ≥ 2.3 with sensitivity 96%, specificity 93%, Area under the curve 0.849 and accuracy 84.9%).

Conclusion: NLR is a predictor of seizure in preterm infants with intra-ventricular hemorrhage.
Study on the Simulation Control of Neural Network Algorithm in Thermally Coupled Distillation
Authors: Zheng Zhao Lan , Qi Yu
Published: July 2021

Thermally coupled distillation is a new energy-saving method, but the traditional thermally coupled distillation simulation calculation process is complicated, and the optimization method based on the traditional simulation process is difficult to obtain a good feasible solution. The neural network algorithm has the advantages of fast learning and can approach nonlinear functions arbitrarily. For the problems in complex process control systems, neural network control does not require cumbersome control structures or precise mathematical models. When training the network, only the input and output samples it needs are given, so that the dynamics of the system can be controlled. In this way, the dynamic performance of the system can be approximated. This method can effectively solve the mathematical model of the thermally coupled distillation process, and quickly obtain the solution of the optimized variables and the objective function. This article summarizes the research progress of artificial neural network and the optimization control of thermally coupled distillation and the application of neural network in thermally coupled distillation.
Haematological and Biochemical Profile of Wistar Rats Exposed to Chloroform Stem Extract of Portulaca oleracea Linn. (Purslane)
Authors: Obinna Victoria C. , Agu Gabriel O.
Published: July 2021

Portulaca oleracea Linn. has a history of extensive use as a medicinal plant and is a component of the Nigerian ethnomedical pharmacopoeia. Although several studies have been carried out exclusively on the leaves to ascertain the physiological effect, there seems to be dearth of literature on the physiological effect of the stem. This study which was designed to fill this gap investigated the sub-chronic effect of oral administration of chloroform stem extract of P.oleracea (CSEPO) on haematological parameters and plasma activities of some enzymes (Alanine Aminotransferase - ALT, Alkaline Phosphatase - ALP & Aspartate Aminotransferase - AST) and levels of other biochemical parameters such as total protein, albumin, bilirubin, urea and creatinine in male wistar rats. Twenty animals were randomly divided into 4 groups of 5 rats each. Group A(Control) received 0.5 ml of olive oil(vehicle) while Groups B, C & D received 125, 250 & 500 mg/kg body weight of CSEPO respectively for 21 days by oral gavage. At the end, the animals were anaesthetized and blood samples were collected for haematology and plasma biochemical assay. No significant (P > .05) variation occurred in the mean values of ALT, ALP, AST, total protein, albumin, bilirubin, urea, creatinine, Packed Cell Volume (PCV), haemoglobin concentration, RBC, WBC and differential leucocyte counts relative to the control. There was a highly significant (P < .01) increase in the total platelet count only at the dose of 500mg/kg in comparison with control. Oral administration of CSEPO as used in this study had no adverse effect on haematological and biochemical parameters. Secondly, CSEPO may be a useful remedy in thrombocytopenia, due to its potential to increase platelet count. However, further study is recommended in that regards.
Short-term Follow-up of Duplex Guided Angioplasty for Femoropopliteal Arterial Occlusive Disease
Authors: Eleiwa Mohamed A. , Aborahma Amr M. , El-Heniedy Mohamed A.
Published: July 2021

Aim: The aim of this study is to evaluate initial and short-term result of duplex guided angioplasty (DGA) for treatment of femoropopliteal arterial lesions.

Methods: From October 2017 to September 2020, 50 limbs in 50 patients (30 males) underwent DGA in our institution. The study was conducted on patients suffered from chronic lower limb ischemia of grade IIb, III and IV (according to Fontaine Classifications) resulting from femoropopliteal lesions (occlusion or stenosis). Arterial access was done under duplex guidance followed by advancing a guidewire across the diseased femoropopliteal segment(s). The diseased segment(s) were then balloon-dilated. Intimal dissection or residual stenosis causing diameter reductions greater than 30% were stented with a self-expandable stent under duplex guidance. Completion duplex examinations and ankle brachial indices were obtained after the procedure.

Results: The mean age of patients was 64 ±8 years. Critical ischemia was the indication in 44%, and disabling claudication was the indication in 6% of cases. Technical success was achieved in 46 cases (92%). 31 cases (62%) went through transluminal crossing of the lesions using duplex guidance alone, 11 cases (22%) went transluminally using duplex combined with contrast-free fluoroscopic assistance and 4 cases (8%) was subjected to subintimal angioplasty using combined techniques. Stenting was done in 24 cases (48%), 16 cases (32%) were having floating intimal flap; while the other 8 cases (16%) had residual stenosis > 30%. A primary patency rate of 92% was obtained by the end of the 12 months follow-up period.

Conclusion: Duplex can be used as a first strategy for the treatment of femoropopliteal arterial diseases. However, the pitfalls in DGA technique make it insufficient to replace the classic fluoroscopy.
Efficacy of Moringa oleifera Leaf Extract for the Treatment of Anemia in Girls
Authors: Shinde M. B. , Waghchoure D. R. , Bhutada S. A. , Dahikar S. B. , Kshirsagar R. V.
Published: July 2021

The Moringa oleifera has proven to be an ancient medicine for for anemia, skin infections, blackheads, anxiety, and pimples, for intestinal worms, lactation, diabetes and pregnancy. Green leafy vegetables and fruits provide much needed essential micronutrients. Moringa leaves in particular are a rich, inexpensive source of micronutrients. In teenage girls a large number of hormonal changes are witnessed and due to the change in diet which lacks the intake of leafy vegetables and fruits that are essential, a large number of anemic cases are observed. To overcome this problems moringa oleifera leaves extract was formulated. 10 girls of the age group ranging between 17-21 years were selected and their haematological investigation was done. Oral administration of this extract was continued for over a month to these girls. After a month haematological investigation were repeated. Haemoglobin of the moringa extract treated group when compared with the before treatment group were , found out to be increased due to the phytochemical constituents in the extract and also presence of minerals and vitamins.
Utilization of Post-Harvest Technologies for Improved Food Security: Case of Maize and Mangoes among Smallholder Farmers in Kerio Valley Elgeyo Marakwet County, Kenya
Authors: Chepwambok L. , Adede W. , Bunyatta D. , Mugalavai V. K. , Onkware A. O.
Published: July 2021

Limited availability of improved post-harvest technologies or inappropriate use of available technologies leads to spoilage of food resulting to post-harvest losses. The losses contribute to food insecurity in the sense that availability and accessibility of food will be limited. Adoption of post-harvest harvest technologies boosts the agricultural sector, and has been seen as a pathway out of poverty and food insecurity. The study assessed the utilization of post-harvest technologies among smallholder farmers in Kerio Valley Elgeyo Marakwet County, Kenya and their correlation to food security. The main objective of the study was to determine factors that influenced adoption of post-harvest technologies for both maize and mango among the farmers. A cross sectional survey was used to collect data using self-administered questionnaire and interview schedules on 217 respondents. There was a significant relationship between gender (r- .264, P<0.001), age(r=.350, P<.05), education level(r=.956, P<.001), income(r=656, P<.001) and extension services(r=.907, P<.001) and adoption of post-harvest technologies. Adoption and use of improved post-harvest and processing technologies need to be promoted to curb post-harvest losses thus improving food security. In addition, there is need for intense extension services on post-harvest technologies to enhance awareness and adoption.
Implementation of Multivariate Exponential Power Distribution in Discrimination and Classification of Psychological Data and Other applications
Authors: Olosund ´ e A. A. , Soy´ınk ´ a´ A. T.
Published: July 2021

Recent advances have shown that some multivariate psychological data are deviating from usual normal assumption either in the tails or kurtosis. Thereby, allowing the call for modelling of such data using more robust elliptically contoured density which includes the normal distribution as a special case. This allowed more flexibility at the kurtosis and tail regions, which is better in handling non-normality in data analysis and also lower the cost of misclassification. The present study employed a robust model for such cases in the context of discrimination and classification of multivariate psychological disorder data using multivariate exponential distribution as an underlining model. Parameters were estimated using the method of maximum likelihood estimation and the discrimination and classification were based on the log likelihood ratio approach. The resulting models relied solidly on the shape parameter, which regulate the tails and the kurtosis, thereby  allowed flexibility. This method enable us to lower the cost of misclassification. Some other areas of applications were also considered in the paper.
Reconstruction of Paleoecology of Early Miocene Subsurface Deposits from Microflora in the Eboïnda Area (South-Eastern Côte d'Ivoire,West Africa)
Authors: Katel Toe-Bi Kahou Kizito , Leger Djeya Kouamé , Behi Zoh Derrick Aurélien , Jean-Paul N’goran , Guede Koré Elysé , Bruno Digbehi Zeli
Published: July 2021

The early Miocene palynoflora was recovered from well P1 located in the Aboisso area, about 175 km around of Abidjan (south-eastern Côte d'Ivoire, West Africa). Pteridophyta spores, angiosperm and gymnosperm pollen grains have been identified. The main objective of this work is to inventory all the palynomorphs encountered, to propose a local palynostratigraphy and to reconstitute the paleobotany of our study area during the Tertiary formations north of the lagoon fault. The samples were processed according to the classical procedure of extraction and concentration of palynomorphs. The lithology contains brown to black clays, coarse to fine sands, and reddish to motley clays. This study showed that the dominance of freshwater ferns such as Verrucatosporites usmensis, Laevigatosporites ovatus, Polypodiaceiosporites simplex, Cingulatisporites pseudocicatricosus and leiotriletes adriensis which evokes a swampy environment. Also the development of Bombacaceae (Bombacacidites annae), and the abundance of Pteridophyte spores of the Polypodiaceae family (Verrucatosporites usmensis, Laevigatosporites ovatus, and Polypodiaceiosporites simplex) indicate the climate was tropical with alternating dry and wet periods. Early Miocene sediments are placed in a continental type environment.
Case Report on Hypothyroidism in Infertile Woman with IVF Conception
Authors: Mohadure Damini S. , Fating Leena
Published: July 2021

Introduction: Hypothyroidism affects 2–4% of women in their reproductive years. Anovulatory cycles, luteal phase defects, hyperprolactinemia, and sex hormone imbalances are all symptoms of sex hormone imbalances are all consequences of hypothyroidism on fertility.

Main Symptoms/or Important Clinical Findings: A 33 years old female admitted in AVBRH on date 19/1/2021 with chief complaint of infertility with hypothyroidism since 8 year, pain in abdomen, irregular menses.

Obstetric History: Patient had obstetric history of menarche start age of 15 year and flow of bleeding in slow/light. After irregular menses, she received IVF cycle and she was conceived the pregnancy in 1st IVF cycle.

The Main Diagnoses, Therapeutic Intervention, and Outcome: After physical examination and investigation, doctor was detected a case of primary infertility with hypothyroidism. Patient was treated with tab.thyronom50 mg drug to reduce the symptoms of hypothyroidism.

Nursing perspective: Administered flued replacement i.e. DNS, RL, monitored fetal heart rate and vital sign per 4 hourly.

Conclusion: Pregnancy conceived with in vitro fertilization increasing the more risk of gestational hypothyroidism as well as fetal complication. Treatment and management improves the outcome of pregnancy.
Factors Affecting Audit Report Lag (Empirical Studies on Manufacturing Listed Companies on the Indonesia Stock Exchange)
Authors: Jura Jacqueline Vania Jessica , Tewu ML Denny
Published: July 2021

The objective of this research is to determine whether Company Size, Company Age, Debt to Equity (DER), Return on Assets (ROA), Audit Opinion, and Auditor Reputation have a significant effect on Audit Report Lag. This research was conducted at manufacturing companies listed on the Indonesia Stock Exchange in the period 2015 to 2019. The study used 93 companies as samples, a total of 490 samples as a whole. The data analysis technique used is multiple linear analysis and the results obtained are that the DER variable has a significant positive effect, while ROA and Audit Opinion have a negative effect on the audit report lag. The variables of company size and auditor reputation do not have a significant effect, while the variable of company age has a significant positive result but is contrary to the initial expectations.
The Role of Knowledge Sharing and Learning Orientation in Improving Innovative Work Behavior among Millennials in Indonesia
Authors: Palumian Yonathan , Gunawan Kristian Alvin , Tarigan Zeplin Jiwa Husada , Umbara Aang Noviana
Published: July 2021

Millennials in Indonesia are now perceived as the main actor of the future generation in the country. As Indonesia is approaching the demographic benefit in 2030-2020, they are expected to innovate in all industrial sectors to support the nationwide development. The purpose of this study is to conduct a prediction on innovative work behavior based on knowledge sharing and learning orientation among millennial workers in Indonesia. This research was conducted under a quantitative approach with a questionnaire-based survey involving 246 millennial respondents working in several sectors. Using partial least square, the finding of this explanatory research implies that learning orientation does have no significant influence on innovative work behavior. However, knowledge sharing has a significant effect on innovative work behavior among Indonesian millennials at the workplace.
Piezoelectric Materials for Energy Harvesting and Sensing Applications: Roadmap for Future Smart Materials
Authors: Mahapatra Susmriti Das , Mohapatra Preetam Chandan , Aria Adrianus Indrat , Christie Graham , Mishra Yogendra Kumar , Hofmann Stephan , Thakur Vijay Kumar
Published: July 2021

Piezoelectric materials are widely referred to as “smart” materials because they can transduce mechanical pressure acting on them to electrical signals and vice versa. They are extensively utilized in harvesting mechanical energy from vibrations, human motion, mechanical loads, etc., and converting them into electrical energy for low power devices. Piezoelectric transduction offers high scalability, simple device designs, and high‐power densities compared to electro‐magnetic/static and triboelectric transducers. This review aims to give a holistic overview of recent developments in piezoelectric nanostructured materials, polymers, polymer nanocomposites, and piezoelectric films for implementation in energy harvesting. The progress in fabrication techniques, morphology, piezoelectric properties, energy harvesting performance, and underpinning fundamental mechanisms for each class of materials, including polymer nanocomposites using conducting, non‐conducting, and hybrid fillers are discussed. The emergent application horizon of piezoelectric energy harvesters particularly for wireless devices and self‐powered sensors is highlighted, and the current challenges and future prospects are critically discussed.
Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial
Authors: Sindi Shireen , Kåreholt Ingemar , Ngandu Tiia , Rosenberg Anna , Kulmala Jenni , Johansson Lena , Wetterberg Hanna , Skoog Johan , Sjöberg Linnea , Wang Hui‐Xin , Fratiglioni Laura , Skoog Ingmar , Kivipelto Miia
Published: July 2021

Introduction

Evidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention.

Methods

Two strategies were adopted, one using combined data from three large Nordic population‐based cohort studies (n = 2289), adopting dementia as outcome, and 2‐year multidomain lifestyle intervention (n = 1260), adopting cognitive change as outcome.

Results

There was higher risk for dementia after age 80 years in women. The positive effects of the lifestyle intervention on cognition did not significantly differ between men and women. Sex‐specific analyses suggested that different vascular, lifestyle, and psychosocial risk factors are important for women and men in mid‐ and late‐life.

Conclusion

Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.
Understanding and Calibration of Charge Storage Mechanism in Cyclic Voltammetry Curves
Authors: Pu Xiangjun , Zhao Dong , Fu Chenglong , Chen Zhongxue , Cao Shunan , Wang Chunsheng , Cao Yuliang
Published: July 2021

Noticeable pseudo‐capacitance behavior out of charge storage mechanism (CSM) has attracted intensive studies because it can provide both high energy density and large output power. Although cyclic voltammetry is recognized as the feasible electrochemical technique to determine it quantitatively in the previous works, the results are inferior due to uncertainty in the definitions and application conditions. Herein, three successive treatments, including de‐polarization, de‐residual and de‐background, as well as a non‐linear fitting algorithm are employed for the first time to calibrate the different CSM contribution of three typical cathode materials, LiFePO4, LiMn2O4 and Na4Fe3(PO4)2P2O7, and achieve well‐separated physical capacitance, pseudo‐capacitance and diffusive contributions to the total capacity. This work can eliminate misunderstanding concepts and correct ambiguous results of the pseudo‐capacitance contribution and recognize the essence of CSM in electrode materials.
γ‐Lactones from Persea americana and Persea fulva – in Vitro and in Silico Evaluation of Trypanosoma cruzi Activity
Authors: Reis Isabella Mary A. , Umehara Eric , Conceição Rodrigo S. , de M. Oliveira Larissa , Coelho dos S. Junior Manoelito , Costa‐Silva Thais A. , Amaral Maiara , Tempone Andre G. , Branco Alexsandro , Lago João Henrique G.
Published: July 2021

In the present study, five known γ‐lactones (majoranolide B – 1, majorenolide – 2, majorynolide – 3, lincomolide D – 4, and isolinderanolide E – 5), as well as a new one (perseanolide – 6), were isolated from Persea fulva and P. americana. All isolated compounds exhibited potential activity against trypomastigote forms of Trypanosoma cruzi, whereas compounds 2 (EC50 of 4.8 μM) and 6 (EC50 of 3.6 μM) displayed superior activity than the positive control benznidazole (EC50 of 16.4 μM), with selectivity index (SI) values of 17.8 and >55.6, respectively (benznidazole, SI>12.2). Molecular docking studies were performed for 1–6 against six T. cruzi molecular targets. Using this approach, we observed that, even though perseanolide (6) showed favorable docking to several studied targets, the results were especially promising for hypoxanthine phosphoribosyl transferase (PDB 1TC1). As PDB 1TC1 is associated to the transference of a monophosphorylated ribose from phosphoribosylpyrophosphate (PRPP) in the ribonucleotide synthesis pathway, this interaction may affect the survival of T. cruzi in mammalian cells. The data herein also indicate that possible intermolecular interactions between 6 and PDB 1TC1 derive from (i) hydrogen bonds in the α,β‐unsaturated‐γ‐lactone unity and (ii) hydrophobic interactions in the long‐chain alkyl group. Based on our results, perseanolide (6), reported for the first time in this work, can auspiciously contribute to future works regarding new trypanocidal agents.
Potential of Single‐Molecule Live‐Cell Imaging for Chemical Translational Biology
Authors: Yoshimura Hideaki
Published: July 2021

Single‐molecule live‐cell imaging is the most direct approach for monitoring the motility of molecules in living cells. Considering the relationship between the motility of molecules and their function, information obtained from single‐molecule imaging involves essential clues for understanding the regulatory mechanisms of the processes of target molecules, and translation to applied sciences such as drug discovery. In this Concept, examples of single‐molecule imaging studies on G protein‐coupled receptors (GPCRs) are mainly introduced, and recent techniques of single‐molecule imaging for overcoming the limitation of single‐molecule live‐cell imaging are discussed. Based on these studies, the prospects of single‐molecule imaging will be outlined.
Liver transplantation for hepatic epithelioid hemangioendothelioma
Authors: Merriam Priscilla , Nathenson Michael J.
Published: July 2021

Hepatic epithelioid hemangioendothelioma is a rare soft tissue sarcoma that may follow an indolent disease course. Liver transplantation is sometimes offered as a treatment option, but its benefit remains unproven, and treatment‐related complications may be significant.
Predictive factors of acute respiratory events during initial induction chemotherapy in patients with advanced neuroblastoma
Authors: Matsui Motohiro , Makimoto Atsushi , Nishio Nobuhiro , Takahashi Yoshiyuki , Urashima Mitsuyoshi , Yuza Yuki
Published: July 2021

Background

Acute respiratory events (ARE) occasionally occur during induction chemotherapy as a complication in patients with advanced neuroblastoma.

Aims

The present study aimed to identify the predictive factors of ARE, defined as severe hypoxia, during initial induction chemotherapy in patients with newly diagnosed advanced neuroblastoma.

Methods and Results

The medical records of 75 consecutive patients in whom stage III or IV neuroblastoma was newly diagnosed between January 2003 and December 2018 at two medical institutions were retrospectively reviewed. The outcome was ARE, which were assessed by measuring oxygen saturation between days 1 and 14 of initial induction chemotherapy. Severe hypoxia was defined as grade 3 or higher according to the Common Terminology Criteria for Adverse Events version 4 (CTCAE v4.0) or decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 ≤55 mmHg). Possible predictive factors on admission were first screened for using univariate analyses with P = .05, then models of the predictive power of the outcome were evaluated by generating receiver operating characteristic (ROC) curves. Eleven patients (14.7%) had the outcome, including three (4.0%) who required respiratory support in the intensive care unit. The area under the curve of the ROC for the predictive factors screened by univariate analyses was 0.84 (95% confidence interval [CI]: 0.73–0.95) for lactate dehydrogenase (LDH) and 0.90 (95% CI: 0.82–0.98) for the disseminated intravascular coagulation (DIC) score.

Conclusion

The LDH value and DIC score on admission may be clinically useful predictors of ARE during initial induction chemotherapy in patients with advanced neuroblastoma.
A clustering‐based anonymization approach for privacy‐preserving in the healthcare cloud
Authors: Abbasi Afsoon , Mohammadi Behnaz
Published: July 2021

Today, modern healthcare systems rely on advanced computational technologies, including cloud‐based systems, to gather and examine personal health data on a large scale. The use of advanced cloud services technologies, such as software as a service, application as a service, is challenging for end‐users of cloud systems to protect sensitive data in their health applications. According to the importance of publishing data in the cloud, the information should be recorded and handled somehow so that any individuals' identity remains hidden. Therefore, one of the critical privacy challenges is protecting the quality of published data and privacy‐preserving on the healthcare cloud simultaneously. The K‐anonymity technology is one of the prevalent methods used for privacy‐preserving. In this article, we suggest a novel approach based on the clustering process using the K‐means++ method to achieve an optimal k‐anonymity algorithm. Also, we use the normal distribution function to delete data that is less frequent, which can be improved the quality of anonymized data. Extensive experiments show the proposed method has been able to reduce information loss 1.5 times and execution time 3.5 times compared to AKA and GCCG algorithms. Also, it is highly scalable than others.