bluuebunny/crossref_metadata_2025 huggingface dataset:
Fuzûlî’nin Türkçe Divan’ında ve Shakespeare’in Sonelerinde Aşk Teması
Authors: BRITTEN Fatoş Işıl
Published: March 2023

Bazen romantik ya da cinsel sevgiyi, bazen Tanrı sevgisi ya da ebeveyn sevgisi gibi farklı sevgi çeşitlerini ifade eden aşk kavramının farklı boyutları bulunmaktadır. Aşk, şüphesiz farklı anlamları ile edebiyat alanında geçmişten günümüze en çok işlenen temalardan biridir. On beşinci ve on altıncı yüzyıl edebiyatına damgasını vurup klasikleşen Fuzûlî ve Shakespeare de gazel ve sone biçimindeki şiirlerinde aşk kavramına yoğun bir şekilde odaklanmıştır. Fuzûlî aşkın ıstıraplarını, sevgiliye ulaşamamanın yarattığı karamsar duyguları gazellerinde dile getirirken Shakespeare de sevgilinin aşığı reddetmesi, unutması ya da aldatması gibi olumsuzluklara sonelerinde oldukça yer verir. Aynı dönemde yaşamalarına rağmen Orta Doğu ve Batı Avrupa gibi farklı coğrafi bölgelerde edebiyat yapan bu şairler aşk kavramını işlerken aynı zamanda aşkın farklı boyutlarına vurgu yapar. Bu çalışmada Klasik Türk edebiyatının en merkezi isimlerinden Fuzûlî’nin Türkçe Divan’ındaki gazelleri ve Rönesans dönemi İngiliz edebiyatının yine en klasikleşmiş edebiyatçılarından Shakespeare’in belli başlı sone örnekleri incelenecektir ve iki şairin eserlerindeki benzerlik ve farklılıklar aşk kavramından yola çıkarak karşılaştırılacaktır.
Geleneğin Sosyal Medya Yolculuğuna Bir Örnek: Diş Hediği
Authors: TARHAN Esra
Published: March 2023

Bebeğin ilk dişinin çıkması Türk kültüründe diş hediği, diş buğdayı gibi adlarla kutlanmaktadır. İlk dişe yönelik kutlamalar çok eski dönemlerden beri devam etmektedir. Çünkü bebeğin dişinin çıkması yeme alışkanlıklarının değişmesine yönelik bir işarettir ve bebeğin gelişiminin iyi yönde olduğunu göstermektedir. Bebeğin diş çıkarması bebek açısından zorlu bir süreçtir. Bebeğin diğer dişlerinin sağlıkla çıkması ve bu süreci daha az zorlukla atlatması amacıyla Türk kültüründe çeşitli uygulamalar gerçekleştirilmektedir. Bebeğin ilk dişini çıkarmasına yönelik olarak hemen hemen her yörede benzer uygulamalar görülmekle birlikte aralarında bazı farklılıklar da olabilmektedir. Bebeğin dişlerinin sağlıkla ve kolaylıkla çıkması için buğday kaynatılmaktadır. Buğdayın kaynatılmasıyla elde edilen hedik gibi bebeğin dişlerinin de kolaylıkla çıkması istenmektedir. Akrabaların ve komşuların bir araya gelerek bebeğin ilk dişinin çıkmasına yönelik kutlamaları son yıllarda elektronik kültür ortamına taşınmıştır.

Elektronik kültür ortamında “diş buğdayı partisi” adı ile düzenlenen kutlamalarda daha fazla kişiye ulaşma isteği dikkat çekmektedir. Bu nedenle genellikle anneler bebeklerinin ilk dişinin çıkması üzerine kutlamalar düzenleyerek bunları Youtube videosu olarak paylaşmaktadırlar. Bu çalışmada “diş buğdayı partisi” adı ile düzenlenen ve Youtube videosu olarak paylaşılan on üç adet video incelenmiştir. Çalışmanın on üç adet video ile sınırlandırılmasının sebebi söz konusu videoların içerik açısından büyük oranda benzerlik göstermesidir. Diş hediği geleneği içerikli Youtube videolarından örneklem alınarak çalışma gerçekleştirilmiştir. Bebeğin ilk dişinin çıkmasını kutlamak için yapılan hazırlıklar, kutlamaya katılanlar, kutlamanın zamanı ve mekânı, diş hediği geleneğine yönelik yaklaşımlar, geleneğe göre çocuğa yaptırılan meslek seçimindeki değişim Youtube videolarından hareketle değerlendirilmiştir. Geleneksel kültürdeki uygulamaların elektronik kültür ortamına taşınmasıyla bazı değişimlere uğradığı görülmüş ve değişen uygulamaların tespit edilmesi amaçlanmıştır. Esas olarak bebeğin ilk dişinin kutlanmasına yönelik hazırlıklardan başlamak üzere hemen hemen her aşamasında değişimin olduğu dikkat çekmiştir. Bu çalışma kapsamında on üç video içerik analizi yöntemiyle incelenmiştir.
Earth observations from the Moon's surface: dependence on lunar libration
Authors: Gorkavyi Nick , Krotkov Nickolay , Marshak Alexander
Published: March 2023

Abstract. Observing the Earth from the Moon's surface has important
scientific advantages. The angular diameter of the Earth as seen from the
Moon's surface is 1.8–2.0∘ (the angular size varies due
to the change in the Earth–Moon distance). The libration of the Moon in
latitude reaches an amplitude of 6.68∘ and has a main period of
27.21 d (or 653.1 h). The libration of the Moon in longitude,
reaching an amplitude of 7.9∘, has a period of 27.55 d (or
661.3 h). This causes the center of the Earth to move in the Moon's sky
in a rectangle measuring 13.4∘ × 15.8∘. The
trajectory of the Earth's motion in this rectangle changes its shape within a
period of 6 years. This apparent librational movement of the Earth in the
Moon's sky complicates observations of the Earth. This paper proposes that this disadvantage be turned into an advantage and that a multi-slit spectrometer be placed on the Moon's surface on a fixed platform. The libration motion and the daily rotation of the Earth will act as a natural replacement for the scanning mechanism.
The Southern Ocean Freshwater release model experiments Initiative (SOFIA): Scientific objectives and experimental design
Authors: Swart Neil , Martin Torge , Beadling Rebecca , Chen Jia-Jia , England Mathew H. , Farneti Riccardo , Griffies Stephen M. , Hatterman Tore , Haumann F. Alexander , Li Qian , Marshall John , Muilwijk Morven , Pauling Andrew G. , Purich Ariaan , Smith Inga J. , Thomas Max
Published: March 2023

Abstract. As the climate warms, the grounded ice sheet and floating ice shelves surrounding Antarctica are losing mass at an increasing rate and injecting the resulting meltwater into the Southern Ocean. This freshwater input could feed back onto climate change, particularly since the Southern Ocean is a key contributor to global heat and carbon uptake. Nonetheless, almost all existing coupled climate models have fixed ice sheets, and lack the physics required to represent the dominant sources of Antarctic melt. These missing ice dynamics represent a key uncertainty that is unaccounted for in current global climate change projections. Previous studies have inserted additional Antarctic meltwater into models, demonstrating that it can alter Southern Ocean stratification, circulation, and sea ice, as well as influence remote atmospheric circulation, tropical precipitation, and global temperature. However, these previous studies have used widely varying rates of freshwater forcing, been conducted using different climate models and configurations, and have reached differing conclusions on the magnitude of meltwater-climate feedbacks. The Southern Ocean Freshwater release model experiments InitiAtive (SOFIA) brings together a team of scientists to quantify the climate system response to Antarctic meltwater input. In this paper, we summarize the state of knowledge on meltwater discharge from the Antarctic ice sheet and ice shelves to the Southern Ocean and explain the scientific objectives of our initiative. We propose a series of coupled and ocean/sea-ice model experiments, including idealized meltwater experiments, historical experiments with observationally consistent meltwater input, and future scenarios driven by meltwater inputs derived from stand-alone ice sheet models. Through coordinating a multi-model ensemble of simulations, with data housed in a common archive, SOFIA will be able to produce a consistent estimate of the climate system response to Antarctic meltwater, as well as the uncertainty of this response.
Semi-continuum modeling of unsaturated porous media flow to explain Bauters' paradox
Authors: Kmec Jakub , Šír Miloslav , Fürst Tomáš , Vodák Rostislav
Published: March 2023

Abstract. In the gravity-driven free infiltration of a wetting liquid into a homogeneous unsaturated porous medium, the flow pattern is known to depend significantly on the initial saturation. Point source infiltration of a liquid into an initially dry porous medium produces a single finger with an oversaturated tip and an undersaturated tail. In an initially wet medium, a diffusion-like plume is produced with a monotonic saturation profile. We present a semi-continuum model, based on a proper scaling of the retention curve, which is discrete in space and continuous in time. We show that the semi-continuum model is able to describe this transition and to capture the experimentally observed dependence of the saturation overshoot and the finger velocity on the initial saturation.
Addressing deep array effects and impacts to wake steering with the cumulative-curl wake model
Authors: Bay Christopher J. , Fleming Paul , Doekemeijer Bart , King Jennifer , Churchfield Matt , Mudafort Rafael
Published: March 2023

Abstract. Wind farm design and analysis heavily rely on computationally efficient engineering models that are evaluated many times to find an optimal solution. A recent article compared the state-of-the-art Gauss-curl hybrid (GCH) model to historical data of three offshore wind farms. Two points of model discrepancy were identified therein: poor wake predictions for turbines experiencing a lot of wakes and wake interactions between two turbines over long distances. The present article addresses those two concerns and presents the cumulative-curl (CC) model. Comparison of the CC model to high-fidelity simulation data and historical data of three offshore wind farms confirms the improved accuracy of the CC model over the GCH model in situations with large wake losses and wake recovery over large inter-turbine distances. Additionally, the CC model performs comparably to the GCH model for single- and fewer-turbine wake interactions, which were already accurately modeled. Lastly, the CC model has been implemented in a vectorized form, greatly reducing the computation time for many wind conditions. The CC model now enables reliable simulation studies for both small and large offshore wind farms at a low computational cost, thereby making it an ideal candidate for wake-steering optimization and layout optimization.
Identifying diversity, equity, and inclusion enhancement opportunities through an online mixed methods library survey
Authors: Morgan-Daniel Jane , Norton Hannah F. , Adkins Lauren E. , Tennant Michele R. , Edwards Mary E. , Daley Matthew
Published: March 2023

Objective: A mixed methods survey was conducted at a health sciences library to assess patrons’ perceptions of the library’s digital and physical environments in relation to diversity, equity, and inclusion (DEI).
Methods: Developed by the library’s DEI Team and preceded by a pilot assessment, the survey posed 17 Likert Scale questions and 2 free-text response questions on the topics of belonging, inclusivity, equitability, emotional and physical safety, and commitment to DEI. The survey was created in Qualtrics, pilot tested, and launched in February 2020 for approximately 12 weeks.
Results: Objective question responses were received from 101 individuals, with 24 open-ended responses. The quantitative findings showed largely positive perceptions of the DEI climate. Questions about feeling welcome and feeling physically safe were among those with the highest responses. The three lower-scoring questions indicate areas for improvement, including services for people whose native language is not English, for individuals with disabilities, and for families. The qualitative findings indicate the library’s strengths include its exhibitions, welcoming atmosphere, and LGBTQ+ inclusivity initiatives. In contrast, opportunities for enhancement encompass non-English language resources, website updates, and accessibility to some physical spaces.
Conclusions: The DEI Team is using the online survey data to enhance HSCL’s services, staffing, programming, policies, and spaces. Employee DEI training is ongoing and the Team is currently analyzing results from a training needs survey to identify unanticipated knowledge gaps. HSCL has a long history of partnering with campus entities, which will help the DEI Team to continually move forward with their work.
Integrating open science education into an undergraduate health professional research program
Authors: Read Kevin B. , Lieffers Jessica , Massie Merle
Published: March 2023

Objective: Open science (OS) is a global movement focused on improving research equity, reproducibility, and transparency of research outputs in publicly funded research. This paper describes how a librarian collaborated with teaching faculty and a research program coordinator to integrate an OS curriculum into an undergraduate professional practice course and assess students’ perceptions of OS after participating.
Methods: A librarian developed an OS-specific curriculum for an undergraduate professional practice course in Nutrition. This course is part of the First Year Research Experience (FYRE) program, which is integrated into 13-week undergraduate courses to introduce students to core elements of the research process in their first year of study by carrying out a research project. The OS curriculum included an Introduction to OS class, a requirement that students share their research outputs in the Open Science Framework, and an assignment asking students to reflect on their experience learning about and practicing OS. Twenty-one of 30 students consented to having their reflection assignment undergo thematic analysis.
Results: Students indicated transparency, accountability, accessibility to research outputs, and increased efficiency as positive attributes of OS. The time commitment, fear of being scooped, and concerns over having research be misinterpreted were considered negative attributes. 90% (n=19) of students indicated that they intend to practice OS in the future.
Conclusion: Based on strong engagement from the students, we believe that this OS curriculum could be adapted to other undergraduate or graduate student contexts where a research project is required.
Health sciences and medical librarians conducting research and their experiences asking for co-authorship
Authors: Bloss Jamie E. , Sewell Kerry , Schellinger Jana , Haberstroh Amanda
Published: March 2023

Objective: Health sciences librarians frequently engage in scholarly publication, both with other librarians undertaking intradisciplinary scholarship, and increasingly as members of research teams centered in other disciplines. We sought to assess the emotional and institutional context of authorship among health sciences librarians, including emotions experienced during authorship negotiation, the frequency with which authorship is denied, and the correlation of perceived support from supervisors and the research community with the number of publications produced. 

Methods: 342 medical and health sciences librarians took an online survey of 47 questions regarding emotions experienced when asking for authorship, denial of authorship, if they have been given authorship without asking, and the extent to which they felt supported to conduct research in their current job.

Results: Authorship negotiation creates varied and complex emotions among librarians. The emotions reported differed when negotiating authorship with librarian colleagues and when negotiating authorship with professionals in another field. Negative emotions were reported when asking either type of colleague for authorship. Respondents reported feeling mostly supported and encouraged by their supervisors, research communities, and workplaces. Nearly one quarter (24.4%) of respondents reported being denied authorship by colleagues outside of their departments. Perceived research appreciation and support by the research community is correlated with the total number of articles or publications produced by librarians.

Conclusions: Authorship negotiation among health sciences librarians involves complex and frequently negative emotions. Denial of authorship is frequently reported. Institutional and professional support appear to be critical to publication among health sciences librarians.
Designing and assessing a data literacy internship program for graduate health sciences students
Authors: McGowan Bethany Sheriese , Ekeigwe Abigail , Clase Kari
Published: March 2023

This case study presents the results of a data internship and workshop series on data analysis in qualitative biomedical systematic reviews. In a newly developed librarian-led internship program, an intern was trained on data literacy concepts and data analysis tools and, in turn, helped recruit and train other graduate health sciences students. Due to COVID-19 restrictions, a flipped classroom model was applied to develop a completely virtual learning experience for both the intern and workshop attendees. Both the data intern and workshop participants reported improved confidence in data literacy competence at the end of the project. Assessment results suggest that while the workshop series improved participants’ data literacy skills, participants might still benefit from additional data literacy instruction. This case also presents a model for student-led instruction that could be particularly useful for informing professional development opportunities for library interns, fellows, and student assistants.
Improved Quality of Services with Intelligent MAC in Wireless Sensor Networks for Mission Critical Applications
Authors: Halkai Abhijit , Terdal Sujatha , Bhasgi Shivani
Published: March 2023

Wireless sensor networks are very feasible to monitor where human reach is impossible. But conserving the limited resource and maintaining Quality of service is the challenging task. There is most need to design an algorithm to maintain quality of services. In this paper we have designed node layered division MAC with adaptive listening based on the queue size at the transmitting cluster node. The proposed protocol attenuates the problem of collision and unfair distribution of power among the nodes. When compared with the existing algorithms, IQMAC outperforms in terms of network lifetime, delay, PDR and collision probability.
International Students in Ontario Secondary Schools: Demystifying the Stereotype
Authors: Schecter Sandra , Merecoulias Maria
Published: March 2023

This article addresses findings of a pilot study focused on the schooling experiences and social and cultural adaptation of international/visa students who have come to Canada to learn English and obtain an Ontario Secondary School Diploma. Nonnative speakers of English and noncitizens of Canada, they are generally brought to Canada by relatives who depart after installing them with host families with whom they have had virtually no previous contact. Respondents reported that most of these youths’ parents have made considerable sacrifices in the hope that acquisition of “legitimate” English will give their child access to global citizenship and a secure future. Findings indicate that many early study abroad international students experience difficulties with second language socialization and are considered “at risk” for academic failure. Testimony from educators and focal students reveals that this cohort experiences significant adaptation issues, including: loneliness and disorientation, depression, and disabling circumstances resulting from injudicious choices.
Ideal Types and Ideal(ized) students in Internationalized Post-secondary Pedagogy
Authors: Walsh Marr Jennifer
Published: March 2023

This article explores the relevance of Weber’s sociocultural concept of ideal types in the context of modern Canadian post-secondary education.  Ideal types are simplified or distilled representations of socio-cultural values, with relevance to various social (Prandy, 2002) and educational (Hayhoe, 2007; Hayhoe & Li, 2017; Wong & Chiu, 2021) analyses. This article builds upon Hayhoe and Li’s (2007) comparison of Confucian and Western ideal types, focusing on implications for internationalized education and implicit values within. The article explores the caveats of reductive thinking regarding cultures, particularly considering culture as a proxy for race where values differ.  It revisits research exploring Western students studying in an East Asian context and East Asian students studying in a Western context (Chen, 2014; Maton & Chen, 2020), using ideal types as an analytical lens for underlying values and gaps in expectations.  Specifically, it considers the pedagogical implications of the differing educational cultures and values as represented by Western and Confucian ideal types, and how a broader appreciation might supplement teaching approaches founded on either type to be more inclusive and beneficial for the various learners in Canadian higher education.
Próbki lakierów samochodowych badane metodą neutronowej analizy aktywacyjnej
Authors: Małoszuk Monika , Dorosz Michał , Głowala Paulina , Wójciuk Karolina , Matulewicz Tomasz
Published: March 2023

Przeprowadzono analizę jakościową składu pierwiastkowego trzydziestu próbek lakierów samochodowych (powłok oryginalnych i nakładanych obecnie w warsztatach lakierniczych) z użyciem dwóch metod fizykochemicznych: fluorescencyjnej spektrometrii rentgenowskiej (XRF) oraz neutronowej analizy aktywacyjnej (NAA). Badania metodą XRF zrealizowano za pomocą zestawu Amptek Experimenter’s XRF Kit. Naświetlania neutronami konieczne do metody NAA wykonano w reaktorze badawczym Maria w Narodowym Centrum Badań Jądrowych w Świerku. Na podstawie uzyskanych wyników można zauważyć, że skład pierwiastkowy pomiędzy próbkami istotnie się różni. Tyko jedna para próbek lakierów badana metodą XRF wykazała identyczny skład pierwiastkowy. Metoda NAA w pełni zróżnicowała wszystkie próbki lakierów. Przeprowadzono ilościowe porównanie zdolności różnicujących obu metod. Jednoznacznie wykazano, że neutronowa analiza aktywacyjna jest metodą bardziej czułą niż fluorescencyjna spektroskopia rentgenowska.
Kryminalistyczne aspekty modus operandi kradzieży z włamaniem w muzeach w Polsce
Authors: Trzebski Franciszek
Published: March 2023

Dzieła sztuki, które znajdują się w zbiorach muzealnych, padają łupem złodziei w wyniku kradzieży z włamaniem. Celem niniejszego artykułu jest przedstawienie przypadków włamań do kilku muzeów w Polsce i przeanalizowanie warunków, w jakich zostały dokonane. Kilka opisanych przypadków kradzieży i okoliczności ich dokonania wskazuje na powtarzalność warunków sprzyjających tego rodzaju przestępstwom. Warunkami sprzyjającymi kradzieży z włamaniami do muzeów są niedostateczna ochrona osobowa lub nierzetelność personelu dozorującego, brak technicznych środków zabezpieczających, np. alarmu, brak społecznej wiedzy o skuteczności karania sprawców takich przestępstw mogącej odstraszać potencjalnych złodziei. Istnieje również potrzeba systematycznego szkolenia pracowników muzeów w zakresie podstawowych środków ochrony tych instytucji przed włamaniami, kradzieżami, napadami, oszustwami, a także doboru personelu pod kątem odpowiedzialności i uczciwości opartego na referencjach i próbnych okresach pracy.
Investigating Psychometric Properties of the Turkish Version of Sosu Critical Thinking Disposition Scale: Evidence from Two Independent Samples
Authors: Orhan Ali
Published: March 2023

This study aimed to examine the psychometric properties of the Turkish version of Sosu Critical Thinking Disposition Scale (TV-CTDS). The data were gathered from two independent samples consisting of undergraduate and graduate students from four different universities in the Black Sea region of Turkey. After the translation procedure, the psychometric properties of the TV-CTDS, including factor structure, measurement invariance, convergent validity, discriminant validity, and reliability, were investigated. The results of the study revealed that the two-factor model (critical openness and reflective skepticism) of the TV-CTDS presented a better fit to the data than the one-factor model, and two-factor model is invariant across different samples (undergraduate and graduate students) and genders. Also, the TV-CTDS showed convergent validity and discriminant validity across two different samples, and its internal consistency was adequate. Therefore, it can be said that the TV-CTDS can be used by educators, researchers, and professionals to assess undergraduate and graduate students’ critical thinking dispositions in Turkey.
ASSOCIATION BETWEEN OBESITY AND LIFESTYLE PRACTICES AMONG ADULTS IN A RURAL COMMUNITY IN EDO STATE NIGERIA
Authors: Oseni T. I. A. , Ahmed S. D. , Eromon P. E. , Fuh N. F. , Azeke O. D.
Published: March 2023

Obesity, a growing global concern, has significant health complications. This descriptive cross-sectional study aimed to determine the relationship the between practices/pattern of lifestyle of the rural population of Igueben and the development of obesity. A semi-structured questionnaire was administered to 360 participants, aged 29 to 60 years, collecting their biodata, sociodemographic characteristics and lifestyle patterns including dietary habits, physical activity, alcohol intake and smoking. Their anthropometry as well as blood pressure and blood glucose were checked and recorded. The mean age of the study population was 45.12±08.23 years with a prevalence of hypertension and diabetes of 14.4% and 32.4% respectively. The majority of the respondents, who were farmers, had a primary level of education. The prevalence of overweight and obesity was high. Significantly associated with obesity were increasing age, female sex, and low levels of education. Other factors this study revealed to be closely associated with obesity include increasing hypertension, an unhealthy diet, physical inactivity, poor sleep and alcohol consumption. Periodic health education will no doubt be beneficial and prevent the concomitant of obesity-related comorbidities.
Existence of solutions to a discrete problems for fourth order nonlinear p-Laplacian via variational method
Authors: Hammouti Omar , El Amrouss Abdelrachid
Published: March 2023

We consider the boundary value problem for a fourth order nonlinear p-Laplacian difference equation and to prove the existence of at least two nontrivial solutions. Our approach is mainly based on the variational method and critical point theory. One example is included to illustrate the result.
3D Printing of Baclofen Gastro-Floating Drug Delivery Systems: A Comparison Study with In vitro and In vivo Evaluation
Authors: Mohammed Abdulkhaleq Nuha , M. Ghareeb Mowafaq
Published: March 2023

This study aims to formulate baclofen gastro-floating drug delivery dosage forms in two different approaches using hot melt extrusion and FDM 3D printing and then compare the effectiveness and select the best formula from the two approaches for further characterization. The first approach involved the preparation of baclofen-loaded filament by HME and then FDM 3D printing of floating tablets with low infill percentages. The second approach involved the formulation of sustained-release tablets by HME and 3D printing of a gastro-floating device (GFD) that holds the tablet inside it. Prepared tablets were tested for drug content, in vitro floating behavior, and in vitro dissolution test, and the optimized formula was tested for DSC, FT-IR, and in vivo radiographic study. Filaments prepared by HME with a diameter of less than 1.3 mm were not printed. Variations in filament diameter affect the printing quality of the 3D printed tablets resulting in tablets' weight variation and failure to float sometimes otherwise tablets were successfully printed and remained floating for 12 hr. Formulas prepared by both approaches with the same composition were found to have significant different dissolution profiles due to the rigid structure formed by 3D printing compared to a compressed tablet. Formulation of the HME tablet and 3D printing of GFD were more reliable and were able to float for more than 12 hr. Optimized formula containing Eudragit RS-100 and ethyl cellulose as release modifier polymers, released the drug and remained floating over 12 hr and this was confirmed by x-ray imaging of Albino rabbit. Formulation of sustained-release tablets by HME and inserting them into 3D printed GFD were found to be superior in terms of producing floating dosage forms compared to 3D printed tablets with low infill percentage.
Effect of CRP, IL-6, Leukocytes, NLR on Chronic Periodontitis in Acute Coronary Syndrome
Authors: Indra Sitompul Sanggap , Susetyo Pikir Budi , Kurnia Supandi Shafira , Estherlita Sinta Monika
Published: March 2023

Chronic periodontitis is associated with coronary heart disease (CHD), including Acute Coronary Syndrome (ACS), which causes inflammation. CRP, IL-6, leukocytes, neutrophils, and lymphocytes are inflammatory mediators. This study aimed to evaluate CRP, IL6, leukocytes, and NLR effect on chronic periodontitis in ACS patients. A total of 60 ACS patients who underwent coronary angiography were used in this study. Coronary artery assessment was measured based on QCA coronary angiography. Periodontal status measured were Oral Hygiene Index (OHI-S), Bleeding on Probing (BOP), and Periodontal Index (PI). The normal-mild limit values of chronic periodontitis were periodontal depth (PD) <4mm, while the moderate-severe of chronic periodontitis was PD ≥ 4 mm. Correlation of CRP, IL-6, leukocytes, and NLR to chronic periodontitis was determined by the Spearman correlation test, followed by path analysis using smartPLS software version 3.0. Additionally, the Goodness of Fit analysis and logistic regression was also conducted. Moderate-severe and normal-mild of chronic periodontitis were found in 45 patients (75%) and 15 patients (25%), respectively. OHI-S, BOP, and PI in moderate-severe chronic periodontitis were significantly higher than in the normal-mild chronic periodontitis group (p<0.05). A comparison of CRP, IL-6, leukocytes and NLR showed no significant value (p>0.05) in both groups. There was no significant positive relationship between CRP, IL-6, leukocytes, and NLR with chronic periodontitis. No direct effect of CRP, IL-6, leukocytes and NLR on chronic periodontitis was found, but female sex and smoking directly affected chronic periodontitis (p<0.05). Female and smoking patients had a higher risk of developing more severe chronic periodontitis with a female OR value of 6.916 (95% CI: 0.470 – 101.798), while the OR smoking was 10.759(95% CI: 1.064 – 108.762). ACS patients were dominated by moderate to severe chronic periodontitis and had worse OHI-S, BOP, and PI. There were no significant effects of CRP, IL-6, leukocytes, and NLR on chronic periodontitis. Our findings revealed a significant direct effect and a high risk of female sex and smoking against chronic periodontitis on ACS patients.
Carotenoid Profile of Freshwater Microalgae Mychonastes racemosus AUP1 and its Antioxidant properties
Authors: Juliari Kusnanda Arif , Dharma Abdi , Armaini Armaini , Syafrizayanti Syafrizayanti , Chaidir Zulkarnain
Published: March 2023

Microalgae contain some active compounds that can be used for various purposes, such as carotenoids and high-value compounds with antioxidant capacity to be used as ingredients for food and pharmaceuticals This study aims to isolate microalgae from freshwater to produce carotenoid pigments. A green microalga was isolated from a local freshwater pond. Morphological observation and molecular analysis were performed to identify the microalgae. The molecular phylogenetic analysis was conducted based on the sequences of 18S rRNA genes. The carotenoid pigments were then extracted from the microalgae using water: methanol: dichloromethane (1:2:1,v/v/v). Further carotenoid pigments were then characterized using ultraviolet–visible (UV–Vis) spectrophotometry, FTIR, and HPLC. The antioxidant activity of the microalgae carotenoid extracts was determined with the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) radical scavenging assay. The results showed that the microalgae belong to the species Mychonastes racemosus AUP1. Carotenoid extracts was obtained from microalgae were about to 86 mg/g dry weight extract was obtained from extraction process of microalgae. Based on FTIR, and HPLC analysis, the microalgae carotenoid extracts contained β-carotene (C40H56) and lutein (C40H56O4). The IC50 value of microalgae carotenoid extract was 78.61 µg/mL. This study suggests that microalgae Mychonastes racemosus AUP1 are potential sources for obtaining carotenoid with strong antioxidant activity. In the future, the microalgae Mychonastes racemosus AUP1 has the potential for prospection of functional foods.
The transmission risk factors of hepatitis B and C infection in dental treating and tattooing among hemodialysis patients
Authors: J. AL-Qaisi Zyad Hussein , J. AL-Qaisi Alaa Hussein , M. Khamis Wessal , Ahmed Hussein Zaman , Rajab Mohammed Iman
Published: March 2023

For four decades, hepatitis often strikes hemodialysis (HD) patients. The seroprevalence of hepatitis infection in HD ranges from country to country. The study design of two parts, the first partisan estimate of the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in Baghdad teaching hospital/departmentof HD, and the second part is an association between HBV, and HCV transmission and other suspected risk factors dental office and tattooing. A one hundred patients who underwent serum anti-HBC and anti-HCV examination at Baghdad teaching hospital/department of dialysis were enrolled in the study. The chemiluminescence assay has been used to test HBV and HCV antibodies, and an automated kinetic method was used for liver function tests. HCVAb was detected in thirty-five (35%) dialysis patients, and the total HBcAb and infection HBsAg were detected in five (5%) and zero (0%) respectively. No Co-infection was observed. Seroprevalence results related to transfusion requirement was 4 (7.4%) for total HBcAb, zero (0%) for HBsAg, and 32 (59.3%) for HCVAb. There was no significant difference between blood transfusion and non-transfusion in risk prevalence of total HBcAb and HBsAg, but the risk of HCV infection was significantly higher in the blood transfusion (p < 0.001). In the logit model analysis, the main risk factor for HCV infection in the entire sample was blood transfusion (OR = 20.8, 95% CI: 5.7-75.7, p < 0.001). The association between HCV transmission and risk behavior among patients that contribute its spread in society such as dental healthcare (DHC) (OR = 0.98, 95% CI: 0.925-1.615, p < 0.05) and tattoos (OR = 0.75, 95% CI: 0.503-1.119). A non-significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin, while, non-significant decrease in albumin in HCV-positive hemodialysis patients compared with HCV-negative dialysis patients. Our findings indicate a high incidence of HCV virus infection in patients who received blood. However, no transmitting risk appeared from such patients when using dental tools or tattoos tools.
Nano-Phytoconstituents and its recent advancement in Anticancer efficacy
Authors: Kumar.V Pavan , Harikrishnan Narayanaswamy
Published: March 2023

Cancer is intense fitness trouble that is still considered to be the main reason for its demise worldwide. Nanotechnology considered as rising disciplines in technology and generation, which may be implemented to synthesize new materials on the nanoscale level. The application of nanotechnology in the treatment of several types of cancers has acquired a significant interest in current years. Cancer nanotechnology is an upcoming unique technique with vast application towards most cancers thru in time diagnosis, estimation and inhibition with the help of personalized medications. Plant occurring natural compounds considered as phytochemicals, crucial assets for most cancers remedy. Some traditional examples consist of curcumin, resveratrol, flavonoids, celastrol, berberine, camptothecins, vinca alkaloids (vincristine and vinblastine), taxol derivatives, and podophyllotoxin derivatives. These phytoconstituents directly act on molecular pathways that are inhibiting in increase and development of several cancers. Phytochemicals used in foods, supplements, and prescribed drugs is inadequate because of lower bioavailability, low solubility, less therapeutic efficacy, and stability problem. To get rid of these issues a modern and advanced novel delivery technique has been developed. These naturally occurring phytochemicals can be incorporated in the form of liposomes, niosomes, nanosomes, nanoparticles, and nanoemulsions to produce better therapeutic efficacy against cancer. This review focuses on the recent advancement and development of nanophytoconstituents in cancer therapy.
An insight of Osthole, Bone marrow mesenchymal stem cells, and BMP-9 loaded carbon-based scaffolds as a Biomaterial candidate in Osteoporosis Therapy: A Narrative Review
Authors: Hafidz Bahtiar Muhammad Riza , Aisyiah Anwar Amelia , Eka Farhana Fitrul Azmi , Prameswari Shelsabilla , Munadziroh Elly
Published: March 2023

Background: More than 200 million people worldwide diagnosed with osteoporosis, a degenerative condition characterized by decreasing bone mineral density. Although oral bisphosphonates are the most used form of treatment for osteoporosis, they have the potential to result in osteonecrosis. Osthole bone marrow mesenchymal stem cells (OBMMSCs) are combination of bone marrow mesenchymal stem cells (BMMSCs) and coumarin derivatives from Cnidium monnieri act as anti-inflammatory and anti-osteoporosis agents. The use of OBMMSCs in triad tissue engineering necessitates using a growth factor and a scaffold, which are combined with BMP-9 incorporated in carbon-based scaffold namely nano hydroxyapatite/collagen I/multi-walled carbon nanotubes (nHA/ColI/MWCNTs) scaffold to promote better loading. The combination of OBMMSCs and BMP-9 loaded nHA/ColI/MWCNTs scaffold has potential to increase OBMMSC differentiation into osteoblasts, resulting in increased bone remodeling and a better outcome in osteoporosis therapy. Purpose: To analyze the potential of OBMMSCs and BMP-9 loaded nHA/ColI/MWCNTs scaffolds as osteoporosis therapy. Discussion: Osthole enhances BMMSCs differentiation via activation of cAMP/CERK and Wnt/β-catenin/BMP signaling pathways. Osthole increases alkaline phosphatase (ALP) expression that stimulates osteogenesis. Meanwhile, in the Wnt/β-catenin-BMP pathway, osthole initiates Wnt binding to the Fz receptor so that β-catenin expression increases. β-catenin, together with Runx2, reduces the expression of GSK-3β, thereby increasing BMMSCs differentiation into osteoblasts. BMP-9 loaded nHA/COLI/MWCNTS scaffold promotes the differentiation of BMMSCs into osteoblasts by increasing the supply of collagen and calcium, as well as angiogenesis, which increases vascularity. Conclusion: OBMMSCs and BMP-9 loaded nHA/ColI/MWCNT scaffold have the potential to treat osteoporosis.
Covid 19 Vaccine – A Magical Bullet for Corona
Authors: Vishnu Kandra Naga , Nagisetty Sindhura , Kumar Uppala Praveen , Uttaravelli Upendrarao , Lavanya Butti , Krishna Balijepalli Murali , Kodandaramu Burli
Published: March 2023

Vaccination is an effective, simple, safeway of providing protection against harmful diseases, before contact with public. Vaccination develops immunity to particular infections and makes our immune system stronger to produce antibodies. Most of the vaccines are administered by parenteral route, but few are given by mouth or sprayed into the nose.We should believe fair and equitable access to safe and effective vaccines is only weapon to end the pandemic, so WHO is hugely working with an effort to encourage the partners to develop and manufacture safe and effective vaccines, a challenging game tool, but in the future we must continue wearing masks, sanitizing our hands, with good ventilation indoors, physical distancing and avoid crowding. Being vaccinated does not mean that we can throw caution to the wind and put ourselves and others at risk, particularly because research is still ongoing on how much vaccines gives protection against disease, infection and transmission.Vaccines may not guarantee protection from infection, they are still doing an amazing job of substantially reducing hospitalization and death related to Covid 19.
Common Edible Essential oils with strong potential against Breast Cancer and their Mechanisms
Authors: Madhavi Boddupalli Bindu , Ramani Ramalingam , Mung’oma Michael , Muraga Margaret , Nath Anisetti Ravinder , Nemala Appalaraju
Published: March 2023

In present scenario of increased mortality due to cancer and highest prevalence of breast cancer, awareness about the treatment options is very crucial. Among the risk factors causing the cancers, diet and nutrition is one of the top risk factor. Edible essential oils are readily found in plant foods and their potential to mitigate cancer remains unexploited. They contain power ingredients that have inhibiting effects to proliferating cells and have mechanisms established against breast cancer cells. Several anticancer studies involving cell lines have demonstrated potent low doses of essential oils from traditional herbs used worldwide as condiments. Breast cancer is a global concern according to the World Health Organization (WHO) and mitigation relies on an informed holistic approach. This review highlights scientific evidence of effective edible essential oils against breast cancer. It covers in vitro and in vivo study findings of common edible essential oils. Future studies should involve determining genetic factors influencing breast cancer response to essential oils.
Orientasi Karyawan Pembentukan Employee Experience di Perusahaan Petrokimia
Authors: Ariandi Arianto , Sukamdani Nugroho BS. , Dyah Maharani Maya Dewi
Published: March 2023

Petrochemical company faces talent competition. Employee Experience (EX) is a new concept that is more profitable and builds Engagement. Research applies orientation as an area of HR management to apply EX. The data obtained through a descriptive approach and associative analysis with analytical tools with the results of orientation preparation, first day of work, first week activities, feedback and evaluation and evaluation of orientation activities have a positive and significant effect on Employee Experience only on the first month's feedback which has no effect positive and significant.
Combustibilidad de las especies de humedales herbáceos en la Reserva de la Biósfera La Encrucijada (México): el uso de ecuaciones alométricas
Authors: Barrios-Calderón Romeo de J. , Infante Mata Dulce , Flores-Garnica José G. , García-Alfaro José R.
Published: March 2023

Los tulares y popales son humedales herbáceos que dan lugar al inicio y propagación de incendios que se expanden hacia humedales arbóreos como los manglares y las selvas inundables. Es por ello que resulta importante evaluar la combustibilidad de esa biomasa herbácea que representa un alto potencial de ignición. Por lo anterior, el objetivo del presente estudio fue determinar las variables alométricas para correlacionar la biomasa del peso seco (combustibilidad) de las especies dominantes de los tulares y popales en tres parajes de la Reserva de la Biósfera La Encrucijada en el Sitio Ramsar 815, ubicado en el sur de México. A partir de ello, se generaron ecuaciones alométricas de las especies más representativas. Las variables evaluadas fueron: altura, cobertura y diámetros (mayor y menor) de las especies de los tulares y popales. Se colectaron individuos de las diez especies más representativas en cuanto a cobertura e índice de valor de importancia y, con ello, se plantearon ecuaciones alométricas empleando los análisis estadísticos correspondientes. Los resultados muestran que las especies del tular de mayor importancia son: Typha domingensis, Cyperus giganteus y Arundo donax; la especie más importante en el popal es Thalia geniculata. La variable altura tiene el mayor coeficiente de correlación con respecto al peso seco en el 70 % de las especies evaluadas, con lo cual se destaca como la más adecuada para construir los modelos alométricos. Sin embargo, en combinación con otras variables, se pueden obtener ecuaciones con un R2 mayor. Los resultados obtenidos permiten valorar los combustibles herbáceos en tulares y popales, calcular su biomasa potencial y definir, en relación con la cobertura y la distribución de las especies, las áreas que son más propensas a incendios.
PNRR. La clausola di condizionalità all’occupazione di giovani e donne: azione positiva o azione mancata?
Authors: Cardinali Valentina
Published: March 2023

Il PNRR presenta come priorità trasversali la parità di genere e generazionale, e quindi l’impegno ad assicurare che l’intero meccanismo di recovery possa determinare un impatto significativo e prevedibile sulla crescita dell’occupazione femminile e giovanile. In tale ambito è prevista una ‘clausola di condizionalità’, un vincolo per gli operatori economici aggiudicatari di bandi: destinare ai giovani under-36 e alle donne senza limiti di età, almeno il 30 per cento dell’occupazione aggiuntiva creata in esecuzione del contratto per le attività essenziali a esso connesse. La misura, disciplinata dall’art. 47 del decreto-legge 31 maggio 2021, n. 77 e dalle Linee guida di cui al D.M. 7 dicembre 2021, si configura tecnicamente come ‘azione positiva’, ossia un dispositivo derogatorio rispetto alle dinamiche ordinarie, finalizzato a raggiungere obiettivi ritenuti di interesse generale che non sono stati raggiunti nel tempo. Il paper analizza la distanza tra la genesi della misura come ‘azione positiva’ e la regolamentazione della sua attuazione all’interno della struttura e delle tempistiche dettate dal PNRR, con un particolare focus sulla disciplina delle deroghe, evidenziando punti di forza e criticità della configurazione del dispositivo, che possono consentire, sin da ora, di tratteggiare il livello di efficacia della misura nel periodo di applicazione nel PNRR.
ОЦЕНКА ГИГИЕНЫ ПОЛОСТИ РТА И РИСК ЗАБОЛЕВАНИИ ПАРОДОНТА У ДЕТЕЙ Г. АКТОБЕ
Authors: Китабаева И.М. , Калдыбаева А.Т. , Жолдасова Н.Ж. , Нургалиева Р.Е. , Аманжолкызы А.
Published: March 2023

Резюме: Стоматология как особо многочисленное медицинское ремесло характеризуется высокой, практически широкой заболеваемостью, точной связью с определенными условиями внешней среды и является одним из направлений здравоохранения, где профилактика дает более значимые результаты. В связи с низкой санитарной культурой и отсутствием мотивации детей и взрослых к профилактике стоматологических заболеваний и гигиене полости рта до сих пор широко распространены заболевания пародонта и кариес зубов. Основным компонентом профилактики стоматологических заболеваний представляется гигиена полости рта. Цель: Оценить гигиеническое состояние и риск заболевании пародонта у детей г.Актобе. Методы и материалы: Для оценки уровня знаний гигиены полости рта было проведено анкетирование 300 детей с помощью валидной анкеты «Анкета о здоровье полости рта для детей», разработанной ВОЗ в 2013 г. В том числе определен заболеваемость по обращаемости и индексы КПИ и Грина-Вермиллиона по учетной форме №043/у-06 «Стоматологическая амбулаторная карта». Статистическая обработка предоставленных данных сделана с использованием программы SPSS 10. Результаты и обсуждение: Плохое состояние зубов отмечали 10% детей, десен – 6,3%. На вопросы использования гигиенических средств для ухода за полостью рта было выявлено, что более 99% детей применяют только основные средства гигиены полости рта. В повседневной жизни дополнительные средства гигиены полости рта используются в очень исключительных случаях. Вдобавок было установлено, что 44% детей не знали, чистят ли они зубы фторсодержащей пастой. По индексу КПИ общий риск к заболеванию составило 26,67%, легкий степень 36,67%, средний 15,67% и тяжелый 21%. Общие проценты по индексу Грина-Вермиллиона составило 39% удовлетворительный, 29,3 плохой, 31% неудовлетворительный и хороший только 0,67%. Выводы: Разбор анкетирования обнаружил у детей недостаточный уровень знаний о гигиене полости рта, что требует тщательного обучения гигиене полости рта для поддержания здоровья полости рта. В результате приобретенных показателей видно, что есть большой риск заболеваний пародонта у детей, и гигиена полости рта оказывает на него прямое влияние.