bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of GARCH models in the volatility of food inflation in Nigeria
Authors: Nzeh Innocent Chile , Ogwuru Hycenth R. , Okolie David Ogomegbunam , Okolie Jonathan Ibekwe
Published: June 2023

This paper aimed to investigate the behavior of the current food inflation volatility arising from the recent past behavior and to know if this volatility is persistent over time in Nigeria. The study covered the period from 2003M1 to 2021M9 under both the asymmetric and the symmetric GARCH models. The findings of the study revealed that one period lag of food inflation had a positive and significant impact on the current value of food inflation. Furthermore, it was found that in all the selected models, volatility in food inflation is persistent and bad news had an impact on food volatility in two of the models, while good news had an impact in one model. However, the asymmetric coefficient in all the asymmetric models is not significant. Consequently, the study contends that policymakers should factor in the impact of recent past values of inflation when framing policies meant to tame food inflation in Nigeria.
Keywords: Asymmetric models, GARCH models, inflation, volatility;
Faktor Pengaruh Kepatuhan Ibu terhadap Imunisasi Dasar Bayi di Puskesmas Abiansemal I Badung Bali
Authors: Astuti Ni Nyoman Sri Puji , Saraswati Putu Ayu Dina , Mastiningsih Putu
Published: June 2023

Imunisasi merupakan upaya untuk mencegah terjadinya penyakit tertentu pada bayi dan anak melalui pembentukan antibody dan peningkatan sistem kekebalan tubuh. Namun, di beberapa negara termasuk Indonesia capaian imunisasi belum mencapai target. Puskesmas Abisenmal I termasuk Puskesmas dengan capaian imunisasi terendah sebesar 45,5% di kabupaten Badung Bali. Tujuan penelitian ini untuk menganalisis faktor yang berhubungan dengan pemenuhan imunisasi dasar pada bayi 0-11 bulan. Desain penelitian yang digunakan dalam penelitian ini adalah cross sectional study. Responden dalam penelitian adalah ibu yang memiliki bayi usia 0-11 bulan yang tercatat di kartu imunisasi berjumlah 78 orang yang dipilih dengan teknik simple random sampling. Instrumen pengumpulan data menggunakan angket. Data dianalisis menggunakan uji statistik chi square. Hasil penelitian menunjukkan bahwa variabel pengetahuan, pendidikan, pekerjaan, dan dukungan keluarga pada bayi usia 0-11 bulan berkaitan signifikan dengan pemenuhan imunisasi dasar pada bayi. Pengetahuan ibu yang baik dan adanya dukungan keluarga terkait imunisasi dasar pada bayi dapat mendukung kepatuhan ibu dalam melaksanakan imunisasi bayi sesuai dengan jadwal imunisasi di posyandu. Hasil penelitian ini diharapkan dapat memberikan manfaat bagi lokasi penelitian sebagai dasar dalam pelaksanaan program edukasi dalam kelas bayi dan balita di posyandu terkait imunisasi dasar bayi dengan melibatkan keluarga atau pendamping ibu yang memiliki bayi usia 0-11 bulan.
Debate Público e Armadilhas da Confiança: cura dos problemas contemporâneos da democracia com mais democracia
Authors: Zambam Neuro José , Francisco José Carlos
Published: June 2023

A desinformação contamina o debate público. A hipótese desta abordagem é: a “cura” dos problemas da democracia  contemporânea deve ocorrer por mudanças individuais e coletivas, especificamente pela: a) construção de redes sociais de confiança; e b) depuração e controle por partidos políticos. As garantias de liberdade e igualdade de participação, sem calar os interlocutores (embora admitida a aplicação da legislação cível e criminal em casos extremos) e as vulnerabilidades da democracia são enfrentadas com práticas construtivas nas praças públicas (off-line e on-line) que interagem com plenários e casas de governos representativos, e na recuperação dos partidos como corpos médios entre a sociedade e o Estado. O debate público e seus sujeitos apontam novos componentes na blogosfera: armadilhas políticas e destruição da credibilidade da política (manipulação da liberdade de expressão e comunicação, e fragilização dos partidos políticos).
The boundaries of legality in criminal prosecution against hacking in the information society
Authors: Fuller Greice Patrícia
Published: June 2023

O artigo examina a possibilidade do uso de equipamentos informáticos legalmente autorizados para o fim de investigação criminal em delitos digitais e para o cumprimento deste desiderato, faz-se uma aproximação analítica entre o Direito e a Arte, objetivando a digressão a respeito de possíveis instrumentos de hacking em face da legislação pátria e estrangeira ante os direitos da privacidade e intimidade. Adota a vertente metodológica jurídico-constitucional e processual penal que procura examinar o direito não apenas como fenômeno ligado à realidade social adjacente, mas como ciência que deve ser dinâmica ante os novos paradigmas tecnológicos. O trabalho é desenvolvido utilizando o método dedutivo, com uma pesquisa baseada em revisão bibliográfica realizada sob o crivo reflexivo-crítico. Conclui-se que há a possibilidade da vigilância legalizada ao modelo de persecução penal frente à sociedade da informação.
Graph neural networks for molecular and materials representation
Authors: Wu Xing , Wang Hongye , Gong Yifei , Fan Dong , Ding Peng , Li Qian , Qian Quan
Published: June 2023

Material molecular representation (MMR) plays an important role in material property or chemical reaction prediction. However, traditional expert-designed MMR methods face challenges in dealing with high dimensionality and heterogeneity of material data, leading to limited generalization capabilities and insufficient information representation. In recent years, graph neural networks (GNNs), a deep learning algorithm specifically designed for graph structures, have made inroads into the field of MMR. It will be instructive and inspiring to conduct a survey on various GNNs used for MMR. To achieve this objective, we compare GNNs with conventional MMR methods and illustrate the advantages of GNNs, such as their expressiveness and adaptability. In addition, we systematically classify and summarize the methods and applications of GNNs. Finally, we provide our insights into future research directions, taking into account the characteristics of molecular data and the inherent drawbacks of GNNs. This comprehensive survey is intended to present a holistic view of GNNs for MMR, focusing on the core concepts, the main techniques, and the future trends in this area.
Epigenetic impact of long non-coding RNA lnc-ADAM9 on extracellular matrix pathway in preterm syndrome through down-regulation of mRNA-ADAM9
Authors: Wang Xiaohua , Liu Aiju , Hou Dongxia , Dong Xiaoyang , Chu Chu , Ju Weina , Zhang Junhui , Jia Yueqi , Yang Xiaoyan , Ji Yunpeng , Wang Tingting , Bonney Elizabeth A. , Wang Guixiang , Zhong Nanbert
Published: June 2023

im: Evidence suggests that the risk of spontaneous preterm birth (sPTB) is the result of environmental exposure interacting with genetic risk and is mediated by epigenetic modification. Long non-coding RNA (lncRNA) comprises a large group of regulators of epigenetic modification that has recently become the focus of increased investigation in reproductive science. Human placenta expresses many lncRNAs, and differential expression profiles (DEPs) have identified several lncRNAs as associated with sPTB. However, little is known about lncRNA’s role in the epigenetic modification of the genes potentially involved in sPTB. This study is to better understand the epigenetic regulation of lncRNA on the development of sPTB. Methods: A transcriptomic analysis of human placentas derived from various pregnancy outcomes was performed as a discovery study. This was followed by a quantitative confirmation to validate the differential transcription of lncADAM9, the lncRNA overlapping with the ADAM9 gene locus, and of lncRNA-overlapped mRNA of ADAM9 (mRNA-ADAM9). In vitro examination of lncADAM9 transgenic (TG) HTR8 cells were used to perform functional assessment to address the role of lncADAM9-mediated epigenetic regulation of extracellular matrix-adhesion (ECM-A) associated molecules. This assessment was then expanded to studies of human fetal membranes. Results: We observed that expression of lncADAM9 was increased in sPTB, and this increase was further associated with the down-regulation of mRNA-ADAM9 in human placentas. In vitro, overexpression of lncADAM9 in lncADAM9-transgenic HRT8 cells led to DEPs relevant to ECM-A molecules, particularly at the loci of CNTN1, NRXN2, SPN, ICAM2, and HLA-DPB1. This was also true in fetal membranes from abnormal versus normal fetal membranes. Conclusion: We have studied the epigenetic impact of differentially expressed lncADAM9 on the ECM-A pathway that is associated with sPTB and documented that this impact may be mediated through the down-regulation of mRNA-ADAM9. Our results of demonstrating the epigenetic regulation of lncADAM9 on the ECM-A pathway may help provide greater insight into critical pathogenic mechanisms underlying sPTB.
The Impact of Tourism Promotion at Andalusian Eight Provinces
Authors: Florido-Benítez Lázaro
Published: June 2023

The aim of this study is to analyse tourism promotion of eight provinces of Andalusia from 2010 to 2022, and to examine the ways that tourism promotion campaigns influence and stimulate the improving of tourism supply and demand at Andalusian provinces. The methodology used in this study collected data from Andalusian public organizations (secondary data), and information related to this topic from researchers and organizations (primary data) for the purpose of this research project. This research provides a new contribution to tourism industry and promotion strategies context. Findings of the current study prove that DMOs of Andalusian provinces increased the tourism promotion budgets and campaigns to revitalize the tourism demand and supply due to the pandemic crisis and Russia’s invasion of Ukraine. Indeed, results of this research suggest that Andalusia’s tourism promotion budgets and campaigns have helped to improve the number of passenger arrivals, number of tourists, hotel occupancy rate, overnight stays at hotels by international and Spanish, and total overnight stay indicators in the period analysed, especially in the years 2021 and 2022. The contribution of this study has a great relevance to tourist destinations, DMOs, hotels, airports, and stakeholders where application of tourism promotion budgets, joint promotion campaigns, and new tourism products and services should be implemented to improve the tourism supply and demand, guarantee the regional and local economy and well-being of population.
Molecular Network for Regulation of Seed Size in Plants
Authors: Zhang Jinghua , Zhang Xuan , Liu Xueman , Pai Qiaofeng , Wang Yahui , Wu Xiaolin
Published: June 2023

The size of seeds is particularly important for agricultural development, as it is a key trait that determines yield. It is controlled by the coordinated development of the integument, endosperm, and embryo. Large seeds are one of the important ways to improve the ultimate “sink strength” of crops, providing more nutrients for early plant growth and showing certain tolerance to abiotic stresses. There are several pathways for regulating plant seed size, including the HAIKU (IKU) pathway, ubiquitin-proteasome pathway, G (Guanosine triphosphate) protein regulatory pathway, mitogen-activated protein kinase (MAPK) pathway, transcriptional regulators pathway, phytohormone regulatory pathways including auxin, brassinosteroid (BR), gibberellin (GA), jasmonic acid (JA), cytokinin (CK), Abscisic acid (ABA), and MicroRNAs (miRNAs) regulatory pathway. This article summarized the seed size regulatory network and prospected ways to improve yield. We expect to provide valuable reference to researcher in the related field.
Laparoscopic Extended Left Lateral Sectionectomy for Hepatocellular Carcinoma in a Patient with Right-Sided Ligamentum Teres: Case Report and Literature Review
Authors: Adachi Yuki , Takahashi Hiroyuki , Yamamoto Tomohiro , Hagiwara Masahiro , Imai Koji , Yokoo Hideki
Published: June 2023

Right-sided ligamentum teres (RSLT) is a rare anatomic variant in which the fetal umbilical vein connects to the right portal vein. Patients with RSLT frequently have hepatic vasculature and bile duct anomalies, which increase the risk of complications with hepatectomy. Most patients with RSLT undergo open hepatectomy. We describe a patient with RSLT and hepatocellular carcinoma who underwent laparoscopic hepatectomy. The patient was a 69-year-old man with hepatocellular carcinoma located in the left liver based on computed tomography (CT) and magnetic resonance imaging. Imaging also demonstrated RSLT. Three-dimensional CT analysis revealed independent right lateral type anomalies of the portal vein and bile duct. Laparoscopic extended left lateral sectionectomy was performed after careful surgical planning. Ultrasonography was used frequently during surgery to avoid damaging the right hepatic vasculature. The left lateral and partial left median sections were removed as planned. The patient’s postoperative recovery was uneventful. Avoiding injury to the right hepatic vasculature is essential when performing left lobectomy, including left lateral sectionectomy, in patients with RSLT. Laparoscopic hepatectomy can be performed safely in patients with RSLT, provided that careful surgical planning is conducted using preoperative three-dimensional CT analysis and intraoperative ultrasonography is used.
Gastroplus and HSPiP Oriented Predictive Parameters as the Basis of Valproic Acid Loaded Mucoadhesive Cationic Nanoemulsion Gel for Improved Nose-To-Brain Delivery to Control Convulsion in Human
Authors: Hussain Afzal , Altamimi Mohammad A. , Mirza Mohd Aamir , Ramzan Mohhammad , Khuroo Tahir
Published: June 2023

Oral and parenteral delivery of first-line anticonvulsant Valproic cid (VA) are associated with serious adverse effects, high hepatic metabolism, high clearance, and low bioavailability in brain. GastroPlus program was used to predict in vivo performance of immediate (IR) and sustained release (SR) products in human. HSPiP software predicted excipients with maximum possible miscibility of the drug. Based on GastroPlus and HSPiP program, various excipients were screened for experimental solubility study and prepared cationic nanoemulsions and respective gels for nasal to brain delivery. These were characterised for size, size distribution, polydispersity index, zeta potential, morphology, pH, % transmittance, drug content, and viscosity. In vitro drug release, ex vivo permeation profile (goat nasal mucosa), and penetration studies were conducted. Result showed that in-vivo oral drug dissolution and absorption were predicted as 98.6 mg and 18.8 mg, respectively from both tablets (IR and SR) at 8 h using GastroPlus. The drug access to the portal vein was relatively predicted high in IR (115 mg) as compared to SR (82.6 mg). Plasma drug concentration-time profile predicted was in good agreement with published reports. The program predicted duodenum and jejunum as the prime site of drug absorption and no effect of nanonization on Tmax for sustained release formulation. Hansen parameters suggested suitable selection of excipients. The program recommended for nasal to brain delivery of the drug using cationic mucoadhesive product. The optimized stable CVE6 was associated with optimal size (113 nm), low PDI (0.26), high zeta potential (+34.7 mV), high transmittance (97.8%), and high strength (0.7 %w/w). In vitro release and ex vivo permeation of CVE6 were found to be substantially high as compared to anionic AVE6 and respective gels. Penetration study executed high fluorescence intensity with CVE6 and CVE6-gel as compared to suspension and ANE6 which may be attributed to electrostatic interaction between mucosal membrane and nanoglobules. Thus, cationic nanoemulsion and respective mucoadhesive gel are promising strategy for delivery of VA to brain through intransal administration for the treatment of seizure and convulsion.
Nf-κβ Inhibitor – Dehydroxymethylepoxyquinomicin Reduces Iron Iso-Maltoside Toxicity Towards Peritoneal Mesothelial Cells
Authors: Breborowicz Andrzej , Umezawa Kazuo
Published: June 2023

Background. Intravenous iron therapy is used in treatment of anemia in uremic pa-tients. In patients treated with peritoneal dialysis iv. infused iron diffuses into the peritoneal cavity and may cause injury to the mesothelial cell.

Methods. We studied effect of Iron Isomaltoside (IIS) in presence of NF-κβ inhibitor dehydroxymethyepoxyquinmicin (DHMEQ) on function of the peritoneal mesothelial cells. Experiments were performed on human peritoneal mesothelial cells in in vitro culture ex-posed to IIS 15 ug/dL ± DHMEQ 1 ug/mL. Intracellular oxidative stress, secretory activity and collagen synthesis in the cells were studied.

Results. IIS induced oxidative stress in the mesothelial cells and that effect was weaker in presence of DHMEQ (-52%,p<0.001). In cells exposed to IIS increased expression of genes for IL6 (+74%,p<0.001), PAI-1 (+43%, p<0.01) and TGFβ (+53%,p<0.001) was observed and reduced for tPA (-36%,p<0.01). In presence of IIS increased secretion of IL6 (+56%, p<0.001), TGFβ (+49%,p<0.001) and PAI-1 (+51%, p<0.001) was observed whereas secretion of tPA was reduced (-25%, p0.001). DHMEQ reduced changes in genes and secre-tory activity caused by IIS. In presence of IIS synthesis of collagen in mesothelial cells was increased (+45%,p<0.001) and that effect was weaker (-25% vs. IIS, p<0001) when simulta-neously DHMEQ was used.

Discussion. IIS induces proinflammatory changes in mesothelial cells, deteriorates their fibrinolytic activity and stimulates synthesis of collagen. All these effects are reduced when simultaneously NF-κβ inhibitor – DHMEQ is used.
Effect of Immobilized Pediococcus acidilactici ORE5 Cells on Pistachio Nuts on Functional Regulation of Novel Katiki Domokou-type Cheese Microbiome
Authors: Pavlatou Chrysa , Nikolaou Anastasios , Prapa Ioanna , Tegopoulos Konstantinos , Plessas Stavros , Grigoriou Maria E. , Bezirtzoglou Eugenia , Kourkoutas Yiannis
Published: June 2023

Nowadays, functional foods supplemented with health-promoting microorganisms have attracted the consumers attention due to their health benefits. However, maintaining high cell loads, which consists of an essential requirement for conferring the health effect is a real bottleneck for the food industry, due to viability decline during food processing and storage. Hence, freeze-drying and cell immobilization have been suggested to enhance cell viability. The aim of our study was to assess the effect of freeze-dried immobilized P. acidilactici ORE5 on pistachio nuts on functional regulation of Katiki Domokou-type cheese microbiome. Supplementation of Katiki Domokou-type cheese with free or immobilized P. acidilactici ORE5 culture resulted in cell loads > 8.5 logcfu/g up to 7 days of storage. Both free and immobilized P. acidilactici ORE5 cells suppressed the growth of L. monocytogenes after deliberate inoculation, acting as a protecting shield. SPME GC/MS analysis showed that incorporation of P. acidilactici ORE5 culture in cheese resulted in an improved volatile compounds profile, as verified by the preliminary sensory evaluation. According to Next-Generation Sequencing analysis, a wide range of bacterial diversity was revealed among samples. The most abundant genus was Lactococcus in all samples, while the results showed increased presence of Pediococcus spp. in cheese fortified with P. acidilactici ORE5 culture, highlighting the ability of the strain to survive in the final product. Furthermore, the incorporation of P. acidilactici ORE5 culture in cheese had a significant impact on cheese microbiome composition, as the presence of spoilage bacteria, such as Chryseobacterium, Acinetobacter and Pseudomonas, were significantly lower compared to the control cheese, indicating quality improvement and prolongation of the product’s shelf- life.
Enhancing Decomposition Approach for Solving Multi-Objective Dynamic Non-Linear Programming Problems Involving Fuzziness
Authors: Kumar Pavan , Khalifa Hamiden Abd El-Wahed
Published: June 2023

In real-life scenario, there are many mathematical tools to handle the incomplete and imprecise data. One of them is the fuzzy approach. This article aims to contribute to the literature of fuzzy multi-objective dynamic programming issues involving the fuzzy objective functions. The piecewise quadratic fuzzy numbers characterize these fuzzy parameters. Some basic notions in the problem under the α-pareto optimal solution concept is redefined and analyzed to study the stability of the problem. Furthermore, a technique, named as enhancing decomposition approach, is presented for achieving a subset for the parametric space that contains the sameα-pareto optimal solution. For a better understanding and comprehension of the suggested concept, a numerical example is provided.
ClimInonda a Web Application for Management the Climate Da-Ta: Case Study of the Flooding Risk in Bayech Transboundary Basin
Authors: Ali Zaineb , Saddik Amine , Erraha Brahim , Labbaci Adnane , Ouessar Mohamed
Published: June 2023

Climate data are important in building a hydrological risk assessment model. The ClimInonda web application enables interactive and dynamic visualizations of different data collected from different weather stations in the study area on a single platform, allowing users to explore and analyze data in an easy way. This can assist decision-makers and stakeholders in understanding the current state of the environment and in identifying areas of flooding risk. Visualizations can include different types of data, such as satellite imagery, weather data, and terrain data, and can be displayed using various techniques, such as heat maps, contour maps, and 3D models by providing easy-to-understand visualizations. The different stations of the Gafsa and Kasserine governorates in the study area are included and other stations of the Algerian territory (Tebessa governorate) are incorporated. This web application also provides the capability to include each user's stations.
Structural Diversity and Carbohydrate-Recognition Mechanisms of Marine Animal Lectins
Authors: Hatakeyama Tomomitsu , Unno Hideaki
Published: June 2023

Glycans play important roles as recognition molecules on cell surfaces in living organisms due to their remarkable structural diversity. Carbohydrates exist in numerous isomeric forms and can adopt diverse structures through various branching patterns. Despite their relatively small molecular weights, they exhibit extensive structural diversity. On the other hand, lectins, also known as carbohydrate-binding proteins, not only recognize and bind to the diverse structures of glycans but also induce various biological reactions based on structural differences. Initially discovered as hemagglutinins in plant seeds, lectins have been found to play significant roles in cell recognition processes in higher vertebrates. However, our understanding of lectins in marine animals, particularly marine invertebrates, remains limited. Recent studies have revealed that marine animals possess novel lectins with unique structures and glycan recognition mechanisms not observed in known lectins. Of particular interest is their role as pattern recognition receptors in the innate immune system, where they recognize glycan structures of pathogens. Furthermore, lectins serve as toxins for self-defense against foreign enemies. Recent discoveries have identified various pore-forming proteins containing lectin domains in fish venoms and skins. These proteins utilize lectin domains to bind target cells, triggering oligomerization and pore formation in the cell membrane. These findings have spurred research into the new functions of lectins and lectin domains. In this review, we present recent findings on the diverse structures and functions of lectins in marine animals.
Analysis of Optimal Source and Application Timing of Nitrogen Fertilizers in Various Soil Types to Minimize Environmental Impacts Caused by Nitrate Leaching
Authors: Sharafi Saeed
Published: June 2023

The use of nitrogen (N) fertilizers can have detrimental effects on the environment due to nitrate leaching. This study aims to examine the impact of N fertilizer source and application timing on wheat yield and nitrate leaching in various soil textures. A randomized complete block design (RCBD) was employed to conduct the experiment. The treatments consisted of two N fertilizer sources: ammonium nitrate (AN) and urea (NN), applied at three different times throughout the year, with a control treatment. The three application timings were total application before sowing (T1), total application in spring (T2), and half the amount before sowing and the other half in spring (T3). The experiment was conducted in three different soil textures (sandy loam, silty clay loam, and silty clay), with three replications over three growing seasons: 2018-19 (Y1), 2019-20 (Y2), and 2020-21 (Y3). The results indicated significant effects of different soil textures on grain yield. Specifically, the silty clay loam soil differed significantly from the sandy loam and silty clay soils in terms of grain yield. The interaction effects between the N fertilizer source and application timing were also found to be significant for all soil textures (p<0.01). In sandy loam and silty clay soils, the grain yield increased when using the T3 application timing compared to the silty clay loam soil. Notably, the silty clay loam soil with the T2 application timing exhibited the highest grain yield, with a yield of 6863.6 kg ha-1. Furthermore, the study revealed that N fertilizers and their application timing significantly influenced the protein content in the silty clay and sandy loam soils. The protein percentages were 10.76 and 10.93 for the silty clay and sandy loam soils, respectively, following the T2 treatment. Additionally, ammonium nitrate (AN) demonstrated a noticeable effect on the percentage of grain protein compared to urea (NN). In conclusion, the application timing of N fertilizers had an impact on grain yield and protein content in different soil textures. Moreover, nitrate concentration increased throughout the experiment, with the highest soil nitrate concentration observed in both fertilizer treatments, particularly in the sandy loam soil.
Evaluating Underwater Light Availability for Phytoplankton: Mean Light Intensity in the Mixed Layer versus Attenuation Coefficient
Authors: Domingues Rita B. , Barbosa Ana B.
Published: June 2023

The use of several light-related variables, such as the Secchi disc depth, the euphotic depth, and in particular, the diffuse attenuation coefficient (Kd), is deeply rooted in phytoplankton research, but these are not the most appropriate indicators of the amount of light available for photosynthesis. We argue that the variable of interest for phytoplankton is the mean light intensity in the mixed layer (Im), which represents the mean light to which phytoplankton cells are exposed throughout their life cycle, while being continuously mixed in the mixed layer. We use empirical data collected in different coastal ecosystems in southern Portugal to demonstrate why Im should be the preferred metric instead of the deeply rooted Kd. We show that, although the relationship between Im and Kd is inversely proportional, it is not always strong or even significant. Different Im values can be associated to the same Kd, but distinct Im have different physiological effects of phytoplankton. Therefore, Kd does not capture the amount of light available for photosynthesis, given that, unlike Im, Kd calculation does not consider the depth of the mixed layer. Therefore, we urge phytoplankton researchers to consider the measurement and calculation of Im when evaluating light-related processes in phytoplankton ecology.
Molecular Evidence of Rickettsia conorii subsp. raoultii and Rickettsia felis in Haemaphysalis intermedia Ticks in Sirumalai, Eastern Ghats, Tamil Nadu, South India
Authors: Nallan Krishnamoorthy , Ayyavu Veerapathiran , Ayyanar Elango , Thirupathi Balaji , Gupta Bhavna , Devaraju Panneer , Kumar Ashwani , Rajaiah Paramasivan
Published: June 2023

Rickettsia is an important pathogenic entity among tick-borne diseases (TBD), which are considered serious emerging public health problems globally. In India, though the widespread distribution of ticks and TBD has been documented, its real burden remains underreported. In a preliminary attempt, rickettsial surveillance was carried out in ticks collected from Sirumalai, Eastern Ghats in Tamil Nadu by using pathogen genome-based phylogenetic inferences generated through multi-locus sequence typing (MLST), targeting the genes 16s rRNA, OmpA, OmpB, and gltA by nested PCR. The laboratory evidence confirms the circulation of Rickettsia in Haemaphysalis intermedia species collected from this area. Analysis of the four gene sequences detected demonstrates their closest identity to the spotted fever group (SFG) available in the GenBank database. Further, multiple sequence alignment with other sequences derived from the GenBank database showed close relatedness to Rickettsia conorii subsp. raoultii (16s rDNA-99.32%, ompA-93.38%, ompB-97.39%, and gltA-98.57%) and Rickettsia felis (ompA-100%, ompB-100% and gltA-99.41%). With this genomic evidence, the circulation of rickettsial pathogens in the pools of H. intermedia ticks infesting livestock in the Sirumalai foothill area has been demonstrated and to complement the microscopic identification of the tick species, DNA barcodes were generated for H. intermedia using the mitochondrial cytochrome c oxidase subunit I gene (COI). Nevertheless, R. raoultii and R. felis were found to be the aetiological agents of tick-borne lymphadenopathy and flea-borne spotted fever in human cases, respectively. Further study on the determination of their diversity, distribution, clinical relevance, and potential risk to the local community in these areas is highly warranted.
Desarrollo sustentable y salud en el medio urbano. El caso de Oaxaca, México
Authors: Cruz Andrés Miguel , López Hernández Ruffo Caín , Miguel Velasco Andrés Enrique , Dávila Núñez Consuelo Mireya
Published: June 2023

En este ensayo se analiza la relación existente entre el estado de salud y el desarrollo sustentable de las ciudades, tomando como referencia el caso de Oaxaca, México. Propone que existe una alta correlación positiva entre estas variables en las ciudades en revisión. Se realizó un estudio longitudinal retrospectivo de datos documentales para crear índices de salud y de desarrollo sustentable, y realizar inferencias de la situación ligada al impacto de la pandemia de COVID19. Los datos se sometieron al análisis estadístico de regresión y de redes
Incidence and prevalence of Neurofibromatosis type 1 and 2: a systematic review and meta-analysis
Authors: Lee Tin-Suet Joan , Chopra Meera , Kim Raymond H , Parkin Patricia C. , Barnett Carolina
Published: June 2023

Objective
To obtain updated estimates of the incidence and prevalence of neurofibromatosis type 1 (NF1) and type 2 (NF2).
Study design:
We conducted a systematic search of NF1 and NF2 incidence or prevalence studies, in OVID Medline, OVID Embase, Web of Science, and Cinahl. Studies were appraised with the Joanna Briggs Institute Prevalence Critical Appraisal tool. Pooled incidence and prevalence rates were estimated through random-effects meta-analysis.
Results
From 1,939 abstracts, 20 studies were fully appraised and 12 were included in the final review. Pooled NF1 prevalence was 1 in 3,190 (95%CI: 1 in 1,140-1 in 4,755). This was higher in studies that screened for NF1, compared to identification of NF1 through medical records (1 in 2,021 and 1 in 4,403, respectively). NF1 pooled birth incidence was 1 in 2,662 (95%CI: 1 in 1,968-1 in 3,601). There were only 2 studies on NF2 prevalence, so data were not pooled. Pooled NF2 birth incidence was 1.08 per 50,000 births (95%CI: 1 in 32,829-1 in 65,019).
Conclusion
The prevalence of NF1 is higher than previously reported, with higher rates seen in screening studies which suggests that the disease may be under recognized. More studies are needed regarding the prevalence of NF2.
Single Relaxation Time and Multiple Revised Matrix Lattice Boltzmann Simulations of Forced Isotropic Turbulence
Authors: Kareem Waleed Abdel
Published: June 2023

The single relaxation time (SRT) and the revised matrix (RM) lattice Boltzmann models are investigated for simulations of three dimensional forced isotropic turbulence with resolutions of 1283, 2563, and 5123, respectively. It is found that the density ρ is almost unity at all lattice timesteps for the MRT case, while disturbance about unity is observed for the SRT case. Also, thinner vortex structures are observed for the MRT results in comparison with the SRT cases specially for higher resolutions. The velocity distributions for the MRT results are found similar to the results of the Navier-Stoks standard solutions. One of the disadvantages of the MRT case is the simulation time which is found more than twice the SRT simulation time, where about 24 seconds are needed for each lattice timestep in the 2563 case in comparison to 12:6 seconds for the SRT model using the same hardware resources. In the case of 5123 grid points about 648 seconds are consumed for one lattice timestep which is found as more than three times the SRT case which needs 198 seconds. The initial velocity field is chosen as u(x; 0) = 0 and the force is injected at low wave-numbers with a fixed forcing amplitude of 10-4 for all cases. The single relaxation time is set to τ = 0.503 in all SRT simulations. Results show that the obtained turbulent velocity fields yield universal characteristics as found in previous Navier-Stoks numerical studies of the same problem.
Effect of Once vs. Twice Intracoronary Injection of Allogeneic-Derived Mesenchymal Stromal Cells after Acute Myocardial Infarction: BOOSTER-TAHA7 Randomized Clinical Trial
Authors: Attar Armin , Kouhanjani Mohsen Farjoud , Hessami Kamran , Vosough Massoud , Kojuri Javad , Ramzi Mani , Hosseini Seyed Ali , Faghih Marjan , Monabati Ahmad
Published: June 2023

Background: Mesenchymal stromal cell (MSC) transplantation can improve the left ventricular ejection fraction (LVEF) after an acute myocardial infarction (AMI). Transplanted MSCs apparently exert a paracrine effect, which might be augmented if repeated doses are administered. This study aimed to compare the effects of single vs.double transplantation of Wharton’s jelly MSCs (WJ-MSCs) on LVEF post-AMI.
Methods: We conducted a single-blind, randomized, multicenter trial. After 3-7 days of an AMI treated successfully by primary PCI, 70 patients younger than 65 with LVEF <40% on baseline echocardiography were randomized to receive conventional care, a single intracoronary infusion of WJ-MSCs, or a repeated infusion ten days later. The primary endpoint was the six-month LVEF improvement as per cardiac magnetic resonance (CMR) imaging.
Results: The mean baseline EF measured by CMR was similar (~40%) in all three groups. By the end of the trial, while all patients experienced a rise in EF, the most significant change was seen in the repeated intervention group. Compared to the control group (n=25), single MSC transplantation (n=20) improved the EF by 4.54 ± 2%, and repeated intervention (n=20) did so by 7.45 ± 2% when measured by CMR imaging (P<0.001); when evaluated by echocardiography, these values were 6.71 ± 2.4 and 10.71 ± 2.5%, respectively (P<0.001).
Conclusions: Intracoronary transplantation of WJ-MSCs 3-7 days after AMI in selected patients significantly improves LVEF, with the infusion of a booster dose ten days later augmenting this effect.
Trial registration: Trial registration: Iranian Registry of Clinical Trials, IRCT20201116049408N1. Registered 20 Nov. 2020 - Retrospectively registered, https://en.irct.ir/trial/52357
Plantar Pressure Analysis in Children with Cerebral Palsy While Wearing Orthoses - a Descriptive Study
Authors: Raposo Maria Raquel , Ricardo Diogo , Veloso Antonio Prieto , João Filipa
Published: June 2023

Background Cerebral Palsy (CP) is the most common cause of motor disability in children, often leading to different musculoskeletal abnormalities, including foot deformities. Ankle-foot orthoses are commonly prescribed to minimize abnormal foot posture and to minimize the impact of spasticity on daily function. Dynamic pedobarography may provide new data to better assess the changes in plantar pressure distribution throughout the stance phase of gait in children with Cerebral Palsy.Methods Nine children with CP walked wearing plantar pressure insoles inside their orthoses and regular footwear. Mean values and standard deviation were calculated for each variable in a total and a segmented foot analysis. Clusters based on clinical distribution of spasticity, gait pattern and type of orthoses were created to allow for further analysis.Results Overall data was consistent across all participants and clusters. The use of AFO did not significantly impact any of the mean values for the variables in study, when referencing to the means of the same variables in children with CP walking in regular footwear. The cluster analysis revealed increased pedobarography values in Unilateral CP, Apparent Equinus gait pattern and Dynamic AFO sub-groups. In the segmented foot analysis, all variables increased from heel to the fore foot.Conclusions The use of AFO in children with CP produce positive changes in plantar pressure measurements, approximating them to the reference percentiles of typically developing children.
A novel prognostic model to predict mortality in patients with acute-chronic liver failure in intensive care unit
Authors: Lin Shih-Hua , Chen Wei-Ting , Tsai Ming-Hung , Liu Li-Tong , Kuo Wei-Liang , Lin Yan-Ting , Wang Sheng-Fu , Chen Bo-Huan , Lee Cheng-Han , Huang Chien-Hao , Chien Rong-Nan
Published: June 2023

Background Acute on chronic liver failure (ACLF) implies high short-term mortality rates and usually requires intensive care unit (ICU) admission. Proper prognosing these patients is crucial for early referral for liver transplantation. The superiority of CLIF-C ACLF score in Asian patients with ACLF admitted to an ICU remains inconclusive when compared to other scoring systems. The purpose of the study is (i) to compare the predictive performance of original MELD, MELD-Lactate, CLIF-C ACLF, CLIF-C ACLF-Lactate, and APACHE-II scores for short-term mortality assessment. (ii) to build and validate a novel scoring system and to compare its predictive performance to that of the original five scores. Methods 265 consecutive cirrhotic patients with ACLF who were admitted to our ICU were enrolled. The prognostic values for mortality were assessed by ROC analysis. A novel model was developed and internally validated using 5-fold cross-validation. Results Alcohol abuse was identified as the primary etiology of cirrhosis. The AUROC of the five prognostic scores in predicting one-month mortality prediction were not significantly superior to each other in predicting one-month and three-month mortality. The newly developed prognostic model, incorporating age, A-a gradient, BUN, total bilirubin level, INR, and HE grades, exhibited significantly improved performance in predicting one-month and three-month mortality with AUROC of 0.863 and 0.829, respectively, as compared to the original five prognostic scores. Conclusions The novel ACLF model is superior to the original five scores in predicting short-term mortality for ACLF patients admitted to an ICU. Further rigorous validation is required.
Concept analysis of a distributed thrust system, a novel induction propulsion method using high energy pulse solenoids in satellite swarms for reusable interorbital freight transport.
Authors: Wegener Morgan J.
Published: June 2023

To date only single vehicle thrust designs have been considered for propulsion in space, however there is no limitation preventing multivehicle distributed thrust application designs. By considering the regularity of planetary orbits and distance between orbital paths, a location in space can be targeted for next orbit arrival of a shipping container propelled on an intercepting vector that is a result of induction propulsion vector combination. This concept is achieved with Nb3Sn high energy pulse solenoids that enable a square pyramidal swarm of satellites to decompose the intercepting orbital transfer vector and propel a 20 tonne steel shipping container towards a destination swarm. This paper is a thought experiment with first pass mechanical analysis that establishes a validity algorithm then concludes that the proposed yoked solenoid design is fit for purpose and the concept is theoretically functional. The launch vector is perpendicular to the swarm’s orbital path thus force application, reaction and orbital maintenance strategies are investigated. A yoke rod’s enhancement of a superconductive solenoid’s force output and the reaction force distribution model are noted as key variances that must be investigated in further research with numerical modelling tools before the proposed design can be considered fully functional and viable for experimental testing. This design is a dedicated freight transport solution to high mass, high volume cargo required by future astronauts, such as construction machinery and materials.
A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.
Authors: Harris Erica , Roy Vincent , Montagne Martin , Rose Ailsa , Livesey Helen , Hobson Emma , Warren Daniel , Long Vernon , Sheridan Eamonn , Reijnders Margot , Sansbury Francis , Willemsen Marjolein , Pfundt Rolph , Brunner Han , Carr Ian , Firth Helen , Lavigne Pierre , Poulter James
Published: June 2023

Cyclin D2 (CCND2) stabilisation underpins a range of macrocephaly-associated disorders through mutation of CCND2, or activating mutations in upstream genes encoding PI3K-AKT pathway components. Here we describe three individuals with overlapping macrocephaly-associated phenotypes who carry the same recurrent de novo p.Arg60Gln variant in Myc-associated factor X (MAX). The mutation, located in the b-HLH-LZ domain, causes increased levels of CCND2 through increased transcription, and not stabilisation of CCND2. We show the purified b-HLH-LZ domain of MAXR60Q (Max*R60Q) binds its target E-Box sequence with a lower apparent affinity. This leads to a more efficient heterodimerization with c-Myc resulting in an increase in transcriptional activity of c-Myc in patients carrying this mutation. The recent development of Omomyc-CPP, a cell penetrating b-HLH-LZ domain c-Myc inhibitor, provides a possible therapeutic option for MAXR60Q patients, and others carrying similar germline mutations resulting in dysregulated transcriptional c-Myc activity.
Emergence of flat bands via orbital-selective electron correlations in Mn-based kagome metal
Authors: Samanta Subhasis , Park Hwiwoo , Jeon Sungmin , Lee C. H. , Cui Hengbo , Hwang Jungseek , Choi Kwang-Yong , Kim Heung-Sik
Published: June 2023

Kagome lattice has been actively studied for the possible realization of frustration-induced two-dimensional flat bands and a number of correlation-induced phases. Currently, the search for kagome systems with a nearly dispersionless flat band close to the Fermi level is ongoing. Here, by combining theoretical and experimental tools, we present Sc3Mn3Al7Si5 as a novel realization of correlation-induced almost-flat bands in the kagome lattice in the vicinity of the Fermi level. Our magnetic susceptibility, 27Al nuclear magnetic resonance, transport, and optical conductivity measurements provide signatures of a correlated metallic phase with tantalizing ferromagnetic instability. Our dynamical mean-field calculations suggest that such ferromagnetic instability observed originates from the formation of nearly flat dispersions close to the Fermi level, where electron correlations induce strong orbital-selective renormalization and manifestation of the kagome-frustrated bands. In addition, a significant negative magnetoresistance signal is observed, which can be attributed to the suppression of flat-band-induced ferromagnetic fluctuation, which further supports the formation of flat bands in this compound. These findings broaden a new prospect to harness correlated topological phases via multiorbital correlations in 3d-based kagome systems.
Nursing Process related to nursing focus "Airway Clearance": A Scoping Review “Nursing Process related to nursing focus "Airway Clearance": A Scoping Review”
Authors: Gaspar Luis Jorge Rodrigues , Reis Neuza Cristina Moura , Sousa Paula Cristina Moreira Mesquita , Silva Abel Avelino Paiva e , Cardoso Alexandrina Maria Ramos , Brito Maria Alice Correia , Morais Ernesto Jorge de Almeida , Bastos Fernanda Santos , Oliveira Manuel Fernando dos Santos , Sousa Inês Maria da Cruz Sousa , Campos Maria Joana Alves , Gonçalves Paulo José Parente , Pereira Filipe Miguel Soares , Machado Natália de Jesus Barbosa
Published: June 2023

Background
Each year, more than a billion people suffer from respiratory diseases leading to about 4 million deaths worldwide. Airway Clearance impairment is deeply related to these diseases causing a significant impact on self-care and quality of life. Therefore, it is essential to identify clinical data, nursing diagnoses and nursing interventions, providing a solid basis for clinical reasoning and integrating the best scientific evidence to enhance nursing care. This scoping review aims to map the existing evidence on clinical data, nursing diagnoses and nursing interventions addressing nursing focus “Airway Clearance”.
Methods
A scoping review was performed according to Joanna Briggs Institute framework. We searched MEDLINE, CINAHL Complete, Scopus, Web of Science, and PEDro databases for published English, Portuguese, and Spanish literature between 1975 and 2021. It included all studies on airway clearance in adult patients in all contexts of nursing care. Quantitative, qualitative, and mixed-methods studies, as well as systematic reviews, were included. The PRISMA-ScR checklist was used.
Results
In total 1355 studies were identified. After removing duplicates, 104 matched the inclusion criteria and were included in the review. The findings of this review showed two areas of nursing attention: one related to signs and symptoms management and the other related to health/illness transition. The data that lead to nursing diagnoses can be divided into cognitive and clinical data. The nursing diagnoses were mostly related to secretions retention, excessive mucus production and airway obstruction. The most commonly identified nursing interventions were the educational interventions assembled into pre-design education programs rather than patient-tailored programs.
Conclusions
The findings of this review can add substantial value for systematising the nursing process related to nursing focus “Airway Clearance”. Reaching a consensus seems highly relevant, as it could improve nursing decision-making, nursing care quality and produce more reliable nursing outcomes.
Effective Implementation of Water Supply Using EPANET Software
Authors: Srivas Rajat , Kumar Hareesh , Kumar Nishank , Dubey Ravi , Gupta Utkarsh
Published: June 2023

In College United Institute Of Technology, Naini, Prayagraj which is the area of case study, the system of water supply assumed in this project is tree or dead end system network for distribution of water in College. The study of our project is related to the effective implementation of water supply using EPANET software in College United Institute Of Technology which provide water distribution network for institutional water demand. The main problem which is try to solve by this project is to know the pressure intensity of water, diameter of pipe, length of pipe , before the installation of pipe on site or land. This project solves all this problems because EPANET software tells the pressure intensity of water, diameter of pipe, length of pipe etc. of any pipe network. The procedure which we followed during this project is to find elevation of ground through which pipes are passed then make a suitable pipe network on EPANET software add nodes, diameter, length of pipes and then do analysis by run it. This result or analysis gives the effective distribution system in United Institute Of Technology College with effective pressure, velocity, and discharge.