bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal Dissociation Methods Differ for N- and O-glycopeptides
Authors: Riley Nicholas , Malaker Stacy A. , Driessen Marc D. , Bertozzi Carolyn
Published: April 2020

Site-specific characterization of glycosylation requires intact glycopeptide analysis, and recent efforts have focused on how to best interrogate glycopeptides using tandem mass spectrometry (MS/MS). Beam-type collisional activation, i.e., higher-energy collisional dissociation (HCD), has been a valuable approach, but stepped collision energy HCD (sceHCD) and electron transfer dissociation with HCD supplemental activation (EThcD) have emerged as potentially more suitable alternatives. Both sceHCD and EThcD have been used with success in large-scale glycoproteomic experiments, but they each incur some degree of compromise. Most progress has occurred in the area N-glycoproteomics. There is growing interest in extending this progress to O-glycoproteomics, which necessitates comparisons of method performance for the two classes of glycopeptides. Here, we systematically explore the advantages and disadvantages of conventional HCD, sceHCD, ETD, and EThcD for intact glycopeptide analysis and determine their suitability for both N- and O-glycoproteomic applications. For N-glycopeptides, HCD and sceHCD generate similar numbers of identifications, although sceHCD generally provides higher quality spectra. Both significantly outperform EThcD methods, indicating that ETD-based methods are not required for routine N-glycoproteomics. Conversely, ETD-based methods, especially EThcD, are indispensable for site-specific analyses of O-glycopeptides. Our data show that O-glycopeptides cannot be robustly characterized with HCD-centric methods that are sufficient for N-glycopeptides, and glycoproteomic methods aiming to characterize O-glycopeptides must be constructed accordingly.
2019-nCoV vs. SARS-CoV: Which Truly Has a Higher ACE2 Affinity? A Quantum Chemical Perspective on Virus-Receptor Noncovalent Interactions
Authors: Sylvetsky Nitai
Published: April 2020

Noncovalent interaction energetics associated with ACE2 affinity differences are investigated using electronic structure methods; Our results were found to challenge previous predictions – claiming a higher affinity for 2019-nCoV compared to SARS-CoV based merely on "chemical intuition". In addition, we demonstrate that a broadly-used classical molecular dynamics force field – MMFF94 – is clearly incapable of reproducing DFT-based noncovalent interaction energetics for the systems at hand (despite being specifically parameterized for van der Waals interactions).
Theoretical Framework of 1,3-Thiazolium-5-Thiolates Mesoionic Compounds: Exploring the Nature of Photophysical Properties and Molecular Nonlinearity
Authors: Liu Zeyu , Hua Shugui , Lu Tian , Tian Ziqi
Published: April 2020

Inspired by a previous experimental study on the first-order hyperpolarizabilities of 1,3-thiazolium-5-thiolates mesoionic compounds using Hyper-Rayleigh scattering technique, we theoretically investigated the UV-Vis absorption spectra and every order polarizabilities of these mesoionic molecules. Based on the fact that the photophysical and nonlinear properties observed in the experiment can be perfectly replicated, our theoretical calculations explored the essential characteristics of the optical properties of the mesoionic compounds with different electron-donating groups at the level of electronic structures through various wave function analysis methods. The influence of the electron-donating ability of the donor on the optical properties of the molecules and the contribution of the mesoionic ring moiety to their optical nonlinearity are clarified, which have not been reported by any research so far. This work will help people understand the nature of optical properties of mesoionic-based molecules and provide guidance for the rational design of molecules with excellent photoelectric performance in the future.
Direct Synthesis of Unprotected 2-Azidoamines from Alkenes via an Iron-Catalyzed Difunctionalization Reaction
Authors: Makai Szabolcs , Falk Eric , Morandi Bill
Published: April 2020

Unprotected, primary 2-azidoamines are versatile precursors to vicinal diamines, which are among the most common motifs in biologically active compounds. Herein, we report their operationally simple synthesis through an iron-catalyzed difunctionalization of alkenes. A wide array of alkene substrates are tolerated, including complex drug-like molecules and a tripeptide. Facile derivatizations of the azidoamine group demonstrate the versatility of this masked diamine motif in chemoselective, orthogonal transformations. Applications of the methodology in the concise synthesis of RO 20-1724 and in a formal total synthesis of (±)-hamacanthin B further demonstrate the broad synthetic potential of this highly functional group tolerant reaction.
Nanorobots Sense Local Physiochemical Heterogeneities of Tumor Matrisome
Authors: Dasgupta Debayan , Pally Dharma , Saini Deepak K. , Bhat Ramray , Ghosh Ambarish
Published: April 2020

The dissemination of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Understanding and quantifying the remodeling of local extracellular matrix (ECM) by invading cells can therefore provide fundamental insights into the dynamics of cancer dissemination. In this paper, we use an active and untethered nanomechanical tool, realized as magnetically driven nanorobots, to locally probe a 3D tissue culture microenvironment consisting of cancerous and non-cancerous epithelia, embedded within reconstituted basement membrane (rBM) matrix. Our assay is designed to mimic the in vivo histopathological milieu of a malignant breast tumor. We find that nanorobots preferentially adhere to the ECM near cancer cells: this is due to the distinct charge conditions of the cancer-remodeled ECM. Surprisingly, quantitative measurements estimate that the adhesive force increases with the metastatic ability of cancer cell lines, while the spatial extent of the remodeled ECM was measured to be approximately 40 μm for all cancer cell lines studied here. We hypothesized and experimentally confirmed that specific sialic acid linkages specific to cancer-secreted ECM may be a major contributing factor in determining this adhesive behavior. The findings reported here can lead to promising applications in cancer diagnosis, quantification of cancer aggression, in vivo drug delivery applications, and establishes the tremendous potential of magnetic nanorobots for fundamental studies of cancer biomechanics.
Supramolecular Encapsulation of Small-Ultra Red Fluorescent Proteins in Virus-Like Nanoparticles for Non-Invasive In Vivo Imaging Agents
Authors: Herbert Fabian C. , Brohlin Olivia , Galbraith Tyler , Benjamin Candace , Reyes Cesar A. , Luzuriaga Michael A. , Shahrivarkevishahi Arezoo , Gassensmith Jeremiah J.
Published: April 2020

Icosahedral virus-like particles (VLPs) derived from bacteriophages Qβ and PP7 encapsulating small-ultra red fluorescent protein (smURFP) were produced using a versatile supramolecualr capsid dissassemble-reassemble approach. The generated fluorescent VLPs display identical structural properties to their non-fluorescent analogs. Encapsulated smURFP shows indistinguishable photochemical properties to its unencapsulated counterpart, exhibits outstanding stability towards pH, and produces bright in vitro images following phagocytosis by macrophages. In vivo imaging allows biodistribution to be imaged at different time points. Ex vivo imaging of intravenously administered encapsulated smURFP reveleas localization in the liver and kidneys after 2 h blood circulation and substantial elimination constructs as non-invasive in vivo imaging agents.
Polyamorphism Mirrors Polymorphism in the Liquid–Liquid Transition of a Molecular Liquid
Authors: Walton Finlay , Bolling John , Farrell Andrew , MacEwen Jamie , Syme Christopher , Jiménez Mario González , Senn Hans Martin , Wilson Claire , Cinque Gianfelice , Wynne Klaas
Published: April 2020

Liquid-liquid transitions between two amorphous phases in a single-component liquid (polyamorphism) have defied explanation and courted controversy. All known examples of liquid–liquid transitions have been observed in the supercooled liquid suggesting an intimate connection with vitrification and locally favored structures inhibiting crystallization. However, there is precious little information about the local molecular packing in supercooled liquids meaning that the order parameter of the transition is still unknown. Here, we investigate the liquid–liquid transition in triphenyl phosphite and show that it is caused by the competition between liquid structures that mirror two crystal polymorphs. The liquid–liquid transition is found to be between a geometrically frustrated liquid to a dynamically frustrated glass. These results indicate a general link between polymorphism and polyamorphism and will lead to a much greater understanding of the physical basis of liquid–liquid transitions and allow the discovery of other examples.
Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax
Authors: Samanas Nyssa B , Engelhart Emily A , Hoppins Suzanne
Published: April 2020

Mitofusins are members of the dynamin-related protein family of large GTPases that harness the energy from nucleotide hydrolysis to remodel membranes. Mitofusins possess four structural domains, including a GTPase domain, two extended helical bundles (HB1 and HB2), and a transmembrane region. We have characterized four Charcot-Marie-Tooth type 2A–associated variants with amino acid substitutions in Mfn2 that are proximal to the hinge that connects HB1 and HB2. A functional defect was not apparent in cells as the mitochondrial morphology of Mfn2-null cells was restored by expression of any of these variants. However, a significant fusion deficiency was observed in vitro, which was improved by the addition of crude cytosol extract or soluble Bax. All four variants had reduced nucleotide-dependent assembly in cis, but not trans, and this was also improved by the addition of Bax. Together, our data demonstrate an important role for this region in Mfn2 GTP-dependent oligomerization and membrane fusion and is consistent with a model where cytosolic factors such as Bax are masking molecular defects associated with Mfn2 disease variants in cells.
VIOLÊNCIA OBSTÉTRICA: COMENTÁRIOS SOBRE O POSICIONAMENTO OFICIAL DO MINISTÉRIO DA SAÚDE A RESPEITO O TERMO
Authors: Rabelo Nunes Iris , Estevão Roberto Da Freiria
Published: April 2020

Este artigo trata do posicionamento oficial adotado pelo Ministério da Saúde quanto ao termo “violência obstétrica”, no qual a agência governamental concluiu que a expressão tem conotação inadequada e que pretende adotar estratégias para sua abolição. Visando analisar as possíveis consequências do posicionamento adotado, o presente estudo irá conceituar a violência obstétrica a fim de demonstrar como esta prática representa uma afronta aos direitos fundamentais das mulheres. Exemplos internacionais que visam prevenir e eliminar quaisquer formas de desrespeito e abuso durante o parto serão apresentados. Por fim, demonstrar-se-á de que formas o posicionamento do Ministério da Saúde é prejudicial.
A LEGALIDADE ESTRITA E SUA APLICAÇÃO FRENTE AOS PRINCÍPIOS DA PROPORCIONALIDADE E DA RAZOABILIDADE NO JULGAMENTO DAS PRESTAÇÕES DE CONTAS
Authors: BERNARDINO JOSE EZEQUIEL ALBUQUERQUE , Coutinho Carlos Marden Cabral
Published: April 2020

O presente artigo faz uma abordagem do uso indiscriminado dos princípios da proporcionalidade e da razoabilidade no julgamento dos processos de prestações de contas dos candidatos eleitorais na seara da Justiça Eleitoral, em detrimento das regras estabelecidas na própria legislação eleitoral, transitando por dois acórdãos paradigmas: um da instância ordinária e outro do Tribunal Superior Eleitoral. Tem-se, nesse percurso, um estudo crítico dos conceitos de proporcionalidade e razoabilidade sob a ótica do TSE e a sua conceituação na visão de Humberto Ávila. Cabe salientar que a presente pesquisa foi embasada em estudo bibliográfico e jurisprudencial do tema.
A APLICAÇÃO DA TERAPIA SOCIAL EMANCIPADORA ENQUANTO ALTERNATIVA À CRISE DO SISTEMA CARCERÁRIO NORTE-RIO-GRANDENSE: UM ENSAIO SOBRE A APAC E A JUSTIÇA RESTAURATIVA
Authors: Martins Tallita , Medeiros Bruna Agra De
Published: April 2020

Trata sobre a ideologia da ressocialização e da reintegração social do apenado no contexto de crise vivenciado pelo sistema carcerário norte-rio-grandense. Metodologicamente, aponta revisão bibliográfica com análise crítica sobre a questão em deslinde, partindo de estudo de campo em visita às instalações da Associação de Proteção e Assistência ao Condenado (APAC) da cidade de Macau/RN, a fim de observar e discutir parâmetros mais efetivos voltados à solução da problemática em tela, debatendo, nesse cenário, sobre a Terapia Social Emancipadora e a implantação de um modelo de justiça restaurativa no estado.
A EXPLORAÇÃO DOS ICEBERGS À LUZ DO TRATADO DA ANTÁRTIDA
Authors: Machado Reinaldo Caixeta , Toledo André De Paiva
Published: April 2020

A população mundial vem travando uma luta contra a escassez de água. Sabe-se que grande parte das reservas de água doce estão localizadas nos polos. Praticamente toda a extensão da Antártida é envolvida por um manto de gelo. Enormes blocos de gelo se desprendem do maciço, sendo lançados à deriva no mar. A princípio, esses recursos podem ser explorados e aproveitados. Porém, o Território Antártico está submetido ao Protocolo de Proteção Ambiental do Tratado da Antártida, que veda qualquer atividade minerária. É necessário verificar a natureza jurídica dos icebergs para então atestar a sua legitimidade de exploração.
A POLÍTICA ECONÔMICA BRASILEIRA PÓS-CRISE DE 2008 SOB A PERSPECTIVA DAS TEORIAS DE KEYNES E HAYEK
Authors: Elias Thiago Sampaio , Bezerra Stéfani Clara da Silva
Published: April 2020

As teorias dos ciclos econômicos de John Maynard Keynes e Friedrich August von Hayek têm muita relevância até os dias atuais nos estudos econômicos. Com o advento da crise econômica mundial, o governo brasileiro utilizou o Estado para interferir na economia estimulando o crédito e aumentando os gastos públicos. Esta medida teve êxito de forma temporária. A mudança de governo alterou profundamente a política econômica do país com a política de austeridade fiscal. São estas políticas econômicas em diferentes momentos do país pós-crise de 2008 que serão abordadas no presente estudo, tendo como base as teorias de Keynes e Hayek.
A PRESERVAÇÃO DO DIREITO À VIDA E UMA DISCUSSÃO SOBRE O PODER DE LEGISLAR: A EQUIPARAÇÃO DA TRANSFOBIA E DA HOMOFOBIA AO RACISMO
Authors: Aragão Ester Oliveira Ferreira , Nobrega Adriano César Oliveira
Published: April 2020

O trabalho objetivou estudar a defesa dos direitos da comunidade LGBTQIA+, correlacionando os avanços traçados pelo Legislativo, Judiciário, ONGs e sociedade. Foi utilizada pesquisa bibliográfica e jurisprudencial sobre a equiparação da homotransfobia ao racismo com a finalidade de verificar se a decisão do STF possui legitimidade. Restou verificado a vida enquanto um direito fundamental para, empós, analisar o ativismo judicial face ao princípio da reserva legal penal e competências legislativas na ótica de Dworkin e Waldron. Concluiu-se que há necessidade de criminalização da homotransfobia, mas que a postura do STF diante do caso em análise possuiu dois vieses contraditórios.
Aspectos Jurídicos do Transplante de Útero: um estudo sob perspectiva da Sociedade da Informação
Authors: Barreto Junior Irineu Francisco , Amorim Denise Souza
Published: April 2020

Este artigo analisa o transplante de útero, técnica experimental de implantação de um órgão de doadora viva ou cadáver em pacientes pré-determinados, enquanto direito à saúde reprodutiva. Destaca que a amplitude do tema saúde e seu destaque na agenda internacional são diretamente relacionados ao histórico social e político dos povos. Conclui que o conceito de saúde não pode ser entendido sem o abrigo dos direitos de liberdade, igualdade e solidariedade entre os povos e as gerações. Ciência e medicina avançam abruptamente, limites estabelecidos por preceitos éticos são necessários e o poder público não pode ser omisso diante dessas mutações.
Isonomia entre homens e mulheres no recebimento de pensão por morte de cônjuge servidora pública: análise comparativa no contexto alemão e brasileiro
Authors: Martins Renata Duval
Published: April 2020

O presente trabalho tem por escopo realizar análise comparativa de decisão proferida, em 1975, pelo Tribunal Constitucional Federal da Alemanha e de decisão proferida, em 2007, pelo Supremo Tribunal Federal do Brasil, ambas versando sobre a violação do princípio da isonomia entre homens e mulheres na aferição do benefício previdenciário de pensão por morte de servidor público. Observam-se discrepâncias entre os regramentos que embasaram a não concessão do benefício pela Administração Pública. No entanto, verifica-se a similaridade da qual decorreu a revogação das normas que embasaram a denegação dos benefícios administrativamente, ou seja, a violação constitucional do princípio da isonomia.
DESCENTRALIZAÇÃO EDUCACIONAL: UM OLHAR CONSTITUCIONAL A PARTIR DO DIREITO FUNDAMENTAL À EDUCAÇÃO
Authors: Campelo da Silva Palhares Tatiane
Published: April 2020

O propósito deste trabalho é enfrentar o seguinte problema: que possibilidades a autonomia e a descentralização educacional apresentam para uma efetiva educação no Estado Democrático de Direito? Construir autonomia a partir de uma descentralização educacional implica “mudanças culturais” profundas nas pessoas. Assim, o presente trabalho objetiva discutir sobre a autonomia e a descentralização educacional. O conceito de descentralização e autonomia indicam a importância para o Estado Democrático de Direito.  O método de trabalho foi o hipotético-dedutivo versando sobre o conceito de autonomia que consiste na construção de conjecturas e situações que permitem alcançar os objetivos da pesquisa.
O PODER DAS EMPRESAS TRANSNACIONAIS E A PRODUÇÃO DA ELISÃO FISCAL: O CASO DO CONSUMO DA COCA-COLA NO MUNDO CONTEMPORÂNEO
Authors: Lazaretti Isadora , Bonissoni Lucas Dalmora
Published: April 2020

Este estudo versa sobre o poder das empresas transnacionais e a produção da elisão fiscal, com base no caso da Coca-Cola no mundo contemporâneo. A pesquisa é realizada adotando-se o método dedutivo e a técnica de pesquisa bibliográfica. O objetivo geral busca verificar o poder das empresas transnacionais e como elas podem produzir elisão fiscal. Considerada uma das marcas mais influentes do mundo, a Coca-Cola efetua manobras fiscais, como a elisão fiscal, consistente na redução do pagamento de tributos, procurando se instalar em países em que os regimes fiscais sejam privilegiados, utilizando indevidamente os destinos fiscais em seu próprio benefício.
Decisões Justas em Processo Administrativo: Há Garantia de Imparcialidade sem Garantia de Independência?
Authors: Domingos Marlyus Jeferton Da Silva
Published: April 2020

O princípio do devido processo legal deve também ser observado nos processos administrativos. Considerando que a decisão de uma autoridade administrativa por vezes pode refletir um verdadeiro julgamento, o artigo tem por objetivo geral analisar a existência de previsão normativa para a imparcialidade e a independência de um julgador e como objetivo específico identificar a possível relação entre elas. Além da pesquisa bibliográfica, foi utilizada como metodologia a observação participante, uma vez que o autor desempenha a função de julgador de litígios em processos administrativos fiscais na Secretaria de Fazenda do Estado do Rio de Janeiro.
O Acesso à Justiça e a Quarta Parede: A Audiência do Artigo 334 do CPC de 2015 como Estratégia Democrática?
Authors: Macedo Elaine Harzheim , Damasceno Marina
Published: April 2020

O presente artigo objetivou analisar o fenômeno da quarta parede, próprio das artes cênicas, no processo quando o jurisdicionado é ignorado pelos operadores e deixado como mero espectador silencioso a resultar em falta de efetividade ao acesso à justiça porque não houve participação do jurisdicionado. Utilizando-se de análise dedutiva, buscou-se averiguar se a audiência preliminar de autocomposição do artigo 334 do CPC age como estratégica democrática para proporcionar papel mais ativo ao jurisdicionado para quebrar essa quarta parede. Concluiu-se que a referida audiência se configura como ferramenta democrática para maior integração entre todos os agentes responsáveis pela composição do conflito.
Processo Tributário Administrativo e Judicial como Instrumento de Acesso à Justiça: Análise Principiológica à Luz do Novo Código de Processo Civil
Authors: Ferreira Ana Paula Duarte
Published: April 2020

Em decorrência do princípio do devido processo legal, a solução de conflitos, em matéria tributária, pode ocorrer tanto na via administrativa quanto na esfera judicial. O processo administrativo tributário é regido por leis editadas pelo ente político constitucional competente para legislar sobre o tributo a cujo respeito versa o conflito a ser solucionado. No âmbito judicial, aplicam-se as normas de processo civil, ou aquelas constantes em legislação especial. Em qualquer caso, deverão ser observados os princípios processuais plasmados na Constituição, os quais objetivam garantir que o processo instrumentaliza o acesso à justiça. Este estudo analisa os princípios processuais administrativos específicos, confrontando-os com aqueles que norteiam o processo civil, com ênfase nas normas fundamentais do processo explicitadas no capítulo primeiro do novo código. A partir daí, busca-se estabelecer de que maneira a recém-sancionada Lei n° 13.105 contribui para a necessária convergência, no campo do Direito Tributário, entre o processo administrativo e o processo judicial.
Da Escola ao Poder Judiciário: Reflexões Sobre o Bullying Escolar e a Judicialização de Conflitos Infanto-Juvenis
Authors: Orsini Adriana Goulart de Sena , Silva Lucas Jeronimo Ribeiro Da
Published: April 2020

Os conflitos e violências intraescolares representam grandes questões a serem enfrentadas em prol da sustentabilidade das relações interpessoais entre alunos nas instituições de ensino. O bullying escolar se avulta, nesse cenário, como uma das principais expressões de violação de direitos entre crianças e adolescentes, sendo hoje considerado um fenômeno da violência em ambiente de ensino, cujos desdobramentos transcendem o espaço da Escola, reverberando no desenvolvimento físico, intelectual e psicossocial dos jovens. Face ao acirramento dessas disputas, o Poder Judiciário tem sido cada vez mais chamado a intervir no campo escolar em um  movimento  de  judicialização  das  relações  educacionais,  suscitando  importantes considerações acerca do adequado acesso à justiça voltado ao público jovem, para além da atuação técnica-jurídica do Magistrado. Nesse sentido, o presente artigo visa propor uma reflexão acerca do bullying escolar e a via jurisdicional de solução dos impasses infanto- juvenis, propondo a mediação e a justiça restaurativa como caminhos possíveis para uma pedagogia  humanista  de  educação  em  solução  dos  problemas  sociais,  em  caráter  de prevenção e gestão de conflitos.
Jurisdição Arbitral e Execução: É Possível a Execução Judicial de Título Executivo em Contrato que Contenha Cláusula Arbitral?
Authors: Pereira Giovanini Ana Elisa Pretto , Assis Borges Nasser Ferreir Jussara Suzi
Published: April 2020

Atualmente, prevalece no Brasil o entendimento de que a arbitragem possui natureza jurídica jurisdicional, e a sentença arbitral equipara-se à sentença judicial, sendo considerada título executivo judicial. Assim, havendo em um mesmo negócio jurídico cláusula arbitral e cláusula com eficácia de título executivo extrajudicial, analisa-se se seria necessário instaurar procedimento arbitral para a prolação de uma sentença acerca do título, ou se este poderia ser executado diretamente no juízo estatal.
O ATENDIMENTO DE CRIANÇAS E ADOLESCENTES COM DEFICIÊNCIA VÍTIMAS DE VIOLÊNCIAS NO SISTEMA DE GARANTIA DE DIREITOS
Authors: Denne Lobão Morais Ana Radig , Monteiro de Brito Filho José Claudio
Published: April 2020

O presente artigo almeja apresentar a criança e o adolescente com deficiência como sujeitos de direitos que necessitam de um atendimento que leve em consideração as necessidades e limitações específicas de cada deficiência. Consideramos para esta análise que a Lei nº 13.431/2017 não abrange vítimas com deficiência, o que só ocorre no Decreto que a regulamenta e ainda assim, de forma insuficiente. Como norma complementar à Lei citada, apresentamos a Resolução Conjunta nº 01 do CONANDA e do CONADE, em uma interpretação que almeja promover o direito ao acesso à justiça destas vítimas. Utilizaremos a metodologia teórica.
Kesehatan Mental dan Koping Strategi di Kudangan, Kecamatan Delang, Kabupaten Lamandau Kalimantan Tengah: Suatu Studi Sosiodemograf
Authors: Saputra Feri Agung , Ranimpi Yulius Yusak , Pilakoannu Rama Tulus
Published: April 2020

Mental health is state of physical, mental and social wellbeing which is allows everyone to live productively in social and financial context so that they can contribute to their community. In 2013 mmental health is still remaining as a serious problem in Indonesia. Many people with mental disorder. About 18.2 % people with mental disorder in rural area were experienced pasung, as well as 10.2 % of people who lived in urban area. Mental disorder is commonly occurred when a person failed to cope and facing the life situations. It needs a right coping strategy to prevent any mental disorder. The purpose of this study is to Â find out peopleâ€™s perception about mental health and the chosen of coping strategy. This study used a qualitative method with fenomenology study design conducted in Kudangan, Delang, lamandau district, central Borneo. Research do itÂ  from June to July 2017. Eight participant research were included in this study which was determined through purposive sampling technique. Data collection is done by field research (field research) that is by passive observation and deep interview with semi structured form. The data were then processed and analyzed using phenomenological analysis. The result of this research is the finding of 6 categories related to participant's perception of mental health, realize self ability, attachment between self and environment, and coping strategy.
Raman-Enhanced Spectroscopy (RESpect) Probe for Childhood Non-Hodgkin Lymphoma
Authors: Agsalda-Garcia Melissa , Shieh Tiffany , Souza Ryan , Kamada Natalie , Loi Nicholas , Oda Robert , Acosta-Maeda Tayro , Choi So Yung , Lim Eunjung , Misra Anupam , Shiramizu Bruce
Published: April 2020

Raman-enhanced spectroscopy (RESpect) probe, which enhances Raman spectroscopy technology through a portable fiber-optic device, characterizes tissues and cells by identifying molecular chemical composition showing distinct differences/similarities for potential tumor markers or diagnosis. In a feasibility study with the ultimate objective to translate the technology to the clinic, a panel of pediatric non-Hodgkin lymphoma tissues and non-malignant specimens had RS analyses compared between standard Raman spectroscopy microscope instrument and RESpect probe. Cryopreserved tissues were mounted on front-coated aluminum mirror slides and analyzed by standard Raman spectroscopy and RESpect probe. Principal Component Analysis revealed similarities between non-Hodgkin lymphoma subtypes but not follicular hyperplasia. Standard Raman spectroscopy and RESpect probe fingerprint comparisons demonstrated comparable primary peaks. Raman spectroscopic fingerprints and peaks of pediatric non-Hodgkin lymphoma subtypes and follicular hyperplasia provided novel avenues to pursue diagnostic approaches and identify potential new therapeutic targets. The information could inform new insights into molecular cellular pathogenesis. Translating Raman spectroscopy technology by using the RESpect probe as a potential point-of-care screening instrument has the potential to change the paradigm of screening for cancer as an initial step to determine when a definitive tissue biopsy would be necessary.
THE INVOLVEMENT OF FATHER IN ORDER TO GIVE NUTRITIOUS FOOD FOR CHILDREN
Authors: Ningsih Tri Ratna , Yanti Ariu Dewi
Published: April 2020

The under five children age is a nutritionally vulnerable group,therefore they require treatment including physical care with the provision of nutritious food especially from the father and mother. The purpose of this research is to know the involvement of father in giving nutritious food to under five children Mojokerto District. The research design is descriptive. The population is all fathers who have under five children as many as 38 people, taken entirely as a sample by using total sampling. The research variable is father's involvement in giving nutritious food to children. Data analysis using percentage.The results showed that most of father's involvement in nutritious food feeding on under-five children is not good as much as 23 people (60,5%). This is motivated by the status of the father who worked as an entrepreneur or not working, elementary education, 36-60 month old childrren and male sex, and working mothers.Time-consuming job as an entrepreneur plus a basic education leads children to may be financially fulfilled but less good in emotional and behaviour involvement. Moreover, the status of unemployment and basic education leads to poor financial and emotional support and behavior. 36-60 months of age and male sex is an active children and tend to be closer to the mother so the father is less involved. Similarly, the status of working mothers does not make the father more involved, because the father tends to require him to work that sacrifice togetherness with children.
HYPNOTHERAPY DECREASES STRESS IN ELDERLY HYPERTENSION
Authors: Kastubi Kastubi , Minarti Minarti , Saudah Noer
Published: April 2020

Stress stimulates the sympathetic nervous encouraging the heart and cause an increasing blood pressure. Efforts to reduce hypertension pharmacological and non-pharmacological. Non-pharmacological experiment of which is hypnosis. The research objective was to analyze the decrease of stress to elderly hypertensive therapy with hypnotherapy. The research design used experimental pretest - Posttest with Control Group. The population were all the elderly with hypertension in the elderly health care center PacarKeling , and Kemayoran Surabaya with 35 elderlies. Number of sample 15 intervention group, 15 control group. The sampling technique used Simple Random Sampling. Variable intervention was therapeutic applications of hypnosis to elderly hypertensive. The dependent variable was the stress in elderly hypertensive. The statistical test used paired t-test. It showed changes in stress to the control group -7.33, while the experminent group amounted to 14.60. Results can reduce stress in the group treated with hypnotherapy an average decrease of 14.6. Results showed that there were differences in the level of stress control and experiment groups with significant value of p = 0.000 (p <0.05), The effect of hypnotherapy was also shown in the systolic blood pressure change between control and experiment groups showed a mean difference of ranks. In the control group 20.8, while in the experimental group 10.2. Mann Whitney test results obtained by the significant value of p = 0.000 (p <0.05) in mean systolic blood pressure differences between control and experiment groups. Hypnotherapy can reduce stress and blood pressure in the experiment group. Causes of stress on the individual such as physical pain, and the outside factor could be due to family problems, economic. Suggestions that hypnosis can be used as a new experiment method stress problem in the elderly
THE INFLUENCE OF PROGRESSIVE MUSCLE RELAXATION TECHNIQUES ON DEPRESSION LEVEL OF CRONIC KIDNEY DISEASE PATIENT UNDERGOING HEMODIALYSIS THERAPY
Authors: Roifah Ifa , Akbar Amar
Published: April 2020

Hemodialysis is a renal replacement therapy for patients with cronic renal disease who are decline of renal fuction. The complex therapy and physical condition of chronic kidney disease and hemodialysis patient involve a severe stressor that lead to depression. Progressive muscle relaxation technique is one of nonpharmacoloical therapies that treat depression. This research aimed to prove the influence of progressive muscle relaxation technique to changes in depression level in cronic kidney disease with hemodialysis in Dr. WahidinSudiroHusodoMojokertohospital. In this research design used is Quasy experiment with pre-test post-test control group design. Sample of 30 people were taken by simple random sampling. 15 people from experimental group were given routine progressive muscle relaxation technique in 2 times a day of the week and 15 people from control group were given not routine progressive muscle relaxation techniques in 2 day one time in a week . The research instrument was Beck Depression Inventory. Wilcoxon  Signed Rank Test shows that p value (0.001) < Î± (0.05), so it is accepted  that there is an effect of progressive muscle relaxation on the depression level of cronic kidney disease patient undergoing hemodialysis. To test the U-Mann Whitney shows that p value (0.005) < Î± (0.05), so that H0 is rejected it means there is different of the channge depression level between experiment group and the control group.this therapy can increase the production of melatonin and serotonin, reduce stress hormone cortisol. PMR also, lowering the muscle tension ,do make positive thinking so,  throught that is influence to decrease in depression level. Routine muscle relaxationdistractify the stressor everyday in training.
Correlation of Nutrition Status with Cognitive Development in Toddler Age Children in Mojowates Rejo Village Kemlagi Subdistrict Mojokerto Regency
Authors: Peni Tri , Santoso Windu , Utami Octavia Ayu pudji
Published: April 2020

Toddler is the most important step of all stages of development. Children of this age have tremendous potential, but the potential will arise when it comes to adequate care, health, attention, affection and education. Malnutrition in early childhood, has an impact on low cognitive abilities. The purpose of this research was to determine the correlation of nutritional status with cognitive development in toddler age children in Mojowates Rejo Village, Kemlagi Sub-district, Mojokerto Regency. The research method was analytic correlation with cross sectional approach. The population in this research were all children of toddler age in Mojowates Rejo Village Kemlagi Sub-district Mojokerto Regency in May 2017 as many as 62 children. Sampling technique used purposive sampling. The sample size were 59 people. The results of this research suggested that more than a half (61.5%) of children with obese nutritional status had good cognitive development, more than a half (61.9%) of children with normal nutritional status had adequate cognitive development, and the majority (100%) Children with thin nutritional status had less cognitive development. Data analysis used in this research was Spearman's rho test with result of Ï value was 0,010 or lessthan Î± (0,05), so H1 is accepted, meantthat there was correlation between nutritional status with cognitive development in toddler age children in Mojowates Rejo Village Kemlagi Sub-district Mojokerto Regency. Parents should provide balanced nutritional intake, control child feeding to avoid obesity, buy educative games to stimulate child development, teach nannies about stimulating child development and allow children to explore the environment without ignoring it.
Improved The Behavior Of The Prevention Of Recurrence Of Hypertension On The Elderly Through Empowerment Support Group
Authors: Hidayati Rina Nur , Ibnu Faisal , Roifah Ifa
Published: April 2020

Hypertension in the elderly can actually be prevented, but the lack of adequate knowledge about the elderly hypertension and prevention efforts are likely to increase the number of occurrence of hypertension and hypertension occurred so often repeated (relapse). With empowerment Support Group is expected to be an increase in prevention of recurrence behavior of hypertension in the elderly. The purpose of the study is to know the influence of the support group against the behavior of the elderly in the prevention of recurrence of hypertension at the village and subdistrict Bicak Trowulan Mojokerto.  The design used was pre experiments with one group pre test and post testdesign. This research sample 24 elderly by using purposive sampling technique. Data collection through the pre test and post test using a questionnaire about the behavior of the elderly in the prevention of recurrence of hypertension. Intervention support group provided for 8 weeks. Data processing is started from the editing, coding, scoring and tabulating. then conducted a test of a different mode. The results showed there was a positive change in behavior in the prevention of recurrence of hypertensive elderly in the village of Trowulan subdistrict of Mojokerto Bicak. Empowerment Support group is effective in improving the behavior of the elderly in the prevention of recurrence of hypertensive diDesa Bicak subdistrict of Mojokerto Trowulan as much as 83.4%, because of the support group is a group that teaches the assistance and guiding the elderly behave healthy life which will result in reducing or eliminating personal and social problems.
AN ANALYSIS ON KNOWLEDGE, PERCEPTION AND SOCIOCULTURAL FACTORS AFFECTING MOTHERâ€™S BEHAVIOR IN GIVING BREASTFEED-SUPPLEMENT MEAL
Authors: Yulianto Yulianto , Lestari Yufi Aris , Chasanah Nur , Festy Pipit , Hadi Nasrul
Published: April 2020

The administration of breastfeed-supplement meal to less than 6-month age baby occurs because mother considers that breastfeed-supplement meal is better than breastfeed. The objective of research is to analyze knowledge, perception and sociocultural factors affecting motherâ€™s behavior in giving breastfeed-supplement meal in less than 6-month age baby. 

The research design used was correlational analytical one with crosssectional approach. The population of research included all mothers of 7-12 month age baby, consisting of 40 mothers. The sample consisted of 37 respondents, taken using simple random sampling technique. Data was collected using questionnaire and tested using linear regression, as well as presented in the form of frequency distribution frequency. 

From the result of regression test, it could be found R value = 0.717, indicating that there is a fairly strong relationship between independent and dependent variables, while coefficient of determinacy or R square value was 0.514 or 51.4%, meaning that independent variable contributed to dependent variable by 51.4%. 

Mothersâ€™ good knowledge on breastfeed-supplement meal can affect their behavior in giving breastfeed-supplement meal because through such knowledge, mothers can recognize and understand how to give breastfeed-supplement meal appropriately to babies. Similarly, perception and socio-cultural factors developing in family or community environment can affect mothersâ€™ behavior
PROGRESSIVE MUSCLE RELAXATION EFFECT ON THE LEVEL ANXIETY of CANCER PATIENTS UNDERGOING CHEMOTHERAPY
Authors: Yuniarti Enny Virda , Rahmawati Ima
Published: April 2020

The physical effects of cancer and its therapy can lead to an unpleasant emotional experience. Long-term treatment of chemotherapy and the presence of perceived side effects can cause anxiety. One of the nonpharmacological measures to overcome this anxiety is the relaxation of Progressive Muscle Relaxation therapy. to know the effect of relaxation Progressive Muscle Relaxation on the level of anxiety in cancer patients who underwent chemotherapy. Independent Variables are Progressive Muscle Relaxation and Dependent Variables of Anxiety Level. This research design uses Pre- Experiment with Pretest-Posttest approach design. Sample amounted to 30 people. Sampling technique Purposive Sampling. The tool used in the HRS-A (Hamilton Rating Scale-Anxiety) questionnaire. The research was conducted from March to April 2017 at Leprosy Hospital SumberGlagahPacet, Mojokerto. Progressive Muscle Relaxation performed one up to two times for 3 weeks with a duration of 15 minutes per session. The test statistic used is to use the Wilcoxon Rank Test test. Ï = 0.046 and Î± = 0.05 so that means H0 rejected and H1 accepted which means there is influence progressive muscle relaxation to the level anxiety cancer patients who underwent chemotherapy at Leprosy Hospital Pacet, Mojokerto. Progressive Muscle Relaxation is recommended as one of the non-pharmacological complementary therapies because this relaxation technique is easy to do and does not cost.
THE EFFECT OF KANGAROO CARE METHOD ON THE CHANGE OF BODY TEMPERATURE IN LOW BIRTH WEIGHT INFANTS (LBWI)
Authors: Sari Bety Maya , Arismawati Dian Fitra , Wardani Riska Aprilia
Published: April 2020

THE EFFECT OF KANGAROO CARE METHOD ON THE CHANGE OF BODY TEMPERATURE IN LOW BIRTH WEIGHT INFANTS (LBWI)

 

Bety Maya Sari1, Dian Fitra Arismawati2, Riska Aprilia Wardani3

Correspondence email : Mayasari.bety@gmail.com

 

Dian Husada Institute of Health Science Mojokerto

 

ABSTRACT

 

Introduction: Low Birth Weight Infants (LBWI) is infants with a birth weight of less than 2500 grams regardless of gestation. Babies with low birth weight (LBW) require proper care in order to avoid harmful things, one of which is Kangaroo Care Method. The purpose of this study is to determine the effect of kangaroo care method on changes in body temperature in LBW infants. Methods: The research design used was pre-experimental with design category (One group pretest-Post). Sampling technique used is consecutive sampling technique. Independent variable in this research is kangaroo care method. Variable dependent in this research is body temperature change. The data were collected through observation analysis with Wilcoxon test to determine whether there was any difference between two samples. The Results: The result of measuring body temperature in Low Birth Weight Infants indicates a change of given intervention kangaroo care method in body temperature with body temperature average of 36.30 C and there are 2 infants who had a decrease in body temperature after a given intervention. The result of statistic test showed that there was effect of kangaroo care method with Z value of 3.114 and with significant level of 0.002.  Conclusion: The results of the research above proves that kangaroo care method can increase body temperature of in infants who experience LBW, so the kangaroo care method could be a substitute for incubator in overcoming hypothermia in LBW infants.

 

Keywords: Kangaroo care method, body temperature, LBWI
the THE CORRELATION BETWEEN SELF-EFFICACY OF POOR MOTHER WITH NUTRITIONAL PATTERN TO UNDER-FIVE CHILDREN
Authors: Ningsih Tri Ratna , Mansur Moh Ali , Efendi Arif
Published: April 2020

Nutrition fulfill was an important thing to be considered in increasing the nutrition status of under-fives, because under five years old children had rapid growth phase. Therefore, the intake of nutrition need to get more attention. The purpose of this research was to analyze the correlation between self-efficacy of mother from poor families with nutritional parenting pattern of under-fives in the area of Mojokerto Regency East Java. The research design used case control with case population which was poor mother with healthy under-fives and control population was poor mother with under-fives who had nutritional problems. The number of sample was 79 people for case group and 41 people for control group. The sampling technique used multi stage sampling. The data collection used questionnaire which had beed tested the validity and reliability to 30 people. The data analysis used statistic chi square test. The research result showed that the correlation of self-efficacy with good parenting pattern as many as 68 people (81,0%) the analysis result with chi square obtained uji p = 0,000, self-efficacy  with good love pattern as many as 52 people (61,9 %) the result analysis with chi square test obtained p = 0,000, self-efficacy with sharpening pattern as many as 57 people (67,9%) the analysis result of chi square test obtained p = 0,000, self-efficacy with nutritional parenting pattern as many as 44 people (52,4%) the result of analysis with chi square test obtained p = 0.001,  value of Î± = 0,05, meant there was correlation between self-efficacy with nutritional parenting pattern of under-fives. The nutritional parenting of under-fives was important to be considered because it had huge impact and prolonged impact on health status, physic and mental development, and also the productivity of children when they grew up, so self-efficacy was needed to give nutrition to their under-fives.
THE RELATIONSHIP OF EMPLOYEE PERCEPTION ABOUT IMPLEMENTATION OF K3 WITH THE USE OF PPE (PERSONAL PROTECTION EQUIPMENT)
Authors: Wahyuningsih Binarti Dwi , Wahyuni Lutfi
Published: April 2020

The use of Personal Protection Equipment (PPE) is the last choice of the method of controlling accident and occupational diseases. Nevertheless, the use of PPE discipline will be critical important for companies and employees to reduce the risk of accidents and occupational diseases. The purpose of of this research is to know the relation of employee perception about implementation of K3 with the use of personal protection equipment (PPE). The design of this research is analytic correlational with cross-sectional aproach 21-27 May 2017. The population this research was employees production unit in UPT. Balai Yasa Surabaya Gubeng. Sample were taken by total sanpling technique as much as 33 respondents. The data were collected with observation for the use of PPE and questionnaires for employee perception about implementation of K3, then tested with a statistical distribution (Crosstab) Chi-Square and are presented in tabular form. The result of the research shown of 33 respondents were 17 respondents (51,5%) who has a positive perception mostly has the use of PPE on the good level and 9 respondents (27,3%) has the use of PPE in the sufficient level. Based on this research gotten a statistical result with a value of the Ï value = 23,209 with Ï= 0,000 or É‘ < 0,05 with this it can be concluded that there is a sognificant relationship between employee perception about implementation of K3 with the use of PPE. Based on this research are expected employees to improve discipline in the use of PPE (Personal Protection Equipment) in complete especially the use of mask and gloves