bluuebunny/crossref_metadata_2025 huggingface dataset:
Endoscopic Ultrasound in Solid Pseudopapillary Tumor of the Pancreas: About two Clinical Cases
Authors: Saidi Idrissi M. , Benjelloun N. , Salihoun M. , Acharki M. , Serraj I. , Hrora A. , Sabbah F. , Belkouchi A. , Znati K. , Kabbaj N.
Published: February 2022

Background: Solid pseudopapillary tumor of the pancreas (SPPT) or Frantz's tumor is a rare exocrine pancreatic tumor, it generally occurs among females within the second or third decade of life. The clinical symptomatology is non-specific, frequently presenting as a slowly growing abdominal mass without any biological abnormalities. The imaging usually shows a well-limited mass with little vascularity. Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) helps the diagnosis. The treatment of these tumors is surgical, and the prognosis is excellent after complete resection. We report two new cases of Frantz tumor, detailing the clinicopathological features of this rare neoplasm. Case presentation: Case 1: A 19-year-old woman presented with middle upper abdominal pain. Computed tomography (CT) scan showed a solitary encapsulated mass in the pancreatic body. Endoscopic ultrasound showed a regular, well-defined, heterogenous lesion, measuring 50 × 46 cm, in the pancreatic body. endoscopic ultrasound fine-needle aspiration was then performed with cytopathological analysis compatible with SPPT. Body computed tomography confirmed the absence of metastases and she underwent a central pancreatectomy. 12 months after the diagnosis, she remains asymptomatic, continuing regular follow-up. Case 2: A 22-year-old woman presented with epigastric pain and weight loss. CT scan revealed a single 5 cm well defined mass in the pancreatic head. EUS showed a well-defined heterogenous hypoechoic encapsulated mass in the pancreatic head, measuring 64 × 44 mm; EUS-FNA was performed and cytopathological analysis was suggestive of SPPT. She underwent conventional cephalic duodenopancreatectomy. She presented septic postoperative complications, with a favorable outcome after medical and surgical therapy. she remains asymptomatic, after 6 months follow-up. Conclusion: Solid pseudo papillary pancreatic tumor is a rare exocrine low-grade neoplasm. EUS is a sensitive tool in the diagnosis of SPPT, identifying and characterizing the pathologic lesions, and allowing EUS-FNA with cytomorphological recognition, making it an invaluable tool for establishing diagnosis, helping clinical management and surgical planning.
Evaluasi Efektifitas Laporan Pemakaian dan Lembar Permintaan Obat (LP-LPO) Puskesmas Kota Jambi
Authors: Salmah Hisran Hamad
Published: February 2022

The importance of valid data means the achievement of lp-LPO objectives as a report on the use and demand of drugs to the installation. The purpose of this study is tosee how effective the monthly report of drugs (LP-LPO) in health centers by measuringindicators of demand accuracy, demand suitability and delivery, accuracy of administration to sub units and measuring the level of drug availability. Effective here means a good report means the availability of an effective drug reporting system in the health center and its network. Method: Research design is descriptively quantitative with an observative and evaluative approach. Data on drug demand and distribution were collected from LPLPO Quarters I, 2,3 and 4. The amount of drugs observed was 20 items of the drug. Observations are made on the  suitability of filling data in the demand column and the distribution of LPLPO between calculations should be in theory with those stated in lp-LPO. Results:  LP-LPO has been able to describe the availability of puskesmas drugs. The average availability of puskesmas drugs is 2.11 months which belongs to the safe category. The suitability of requests and calculations, submitted by puskesmas through LP-LPO is good enough, according to 61.5% is in accordance with the calculation according to standards. The suitability of puskesmas request submitted through LP-LPO, 80.3% is in accordance with the grant given by the Pharmaceutical installation
Pengalaman Kepala Ruangan dalam Mengelola Ruangan yang Merawat Pasien Covid 19
Authors: Relly Brension , Afiyanti Yati , Syafwani Muhammad
Published: February 2022

The recent Covid 19 outbreak has grown from a public health emergency to a major global pandemic. As the Covid 19 pandemic emerged as a global health care crisis, scientists around the world were actively developing prophylactic and therapeutic interventions. During the pandemic, the management of the chief strategist played a very important role. The strategy taken must be able to adapt very quickly, whether organizational, corporate, business unit, or operational level. The management of Man, Money, Materials, Machines, and Methods in the element of management becomes crucial to be managed by a head of the room This research aims to explore in depth the Experience of the Head of Room in managing the Room That Cares for Covid 19 Patients. Research methods with  qualitative data were obtained through indepth interviews on 10 participants of Hospital A and B in Palangka Raya central Kalimantan using qualitative methods with purposive sampling techniques. The results of the study found 6 main themes, namely (1). Management of Resources of Manausia Nurse, (2). Financial Management, (3). availability of consumables, (4). Readiness of medical devices, (5) Room management methods, (6). evaluation of management of human resources management, finance, facilities, availability of tools, room governance methods. The results of this study concluded that the management and evaluation of the head of the room during the Covid 19 pandemic needs the management of human resources, finance, availability of consumables, tools and methods of room governance to be of particular concern to hospital managers who provide health services to Covid 19 patients.
Pengalaman Perawat Jiwa Melakukan Self Manajemen Diri dalam Mengelola Stres Dimasa Pandemi Covid-19
Authors: Maradona Maradona , Afiyanti Yati , Syafwani Muhammad
Published: February 2022

The emergence of the COVID-19 Virus has attracted global attention, and On January 30 WHO has declared COVID-19 a public health emergency of international concern. The disease caused by the severe acute respiratory syndrome coronavirus has been reported worldwide more than 2 million cases, including more than 120,000 deaths. Meanwhile in Indonesia, according to data from the Ministry of Health of the Republic of Indonesia in 2020 until March 25, 2020, a total of 414,179 confirmed cases were reported with 18,440 deaths, 4.4% of which cases were reported in 192 countries/regions. Work stress during this pandemic is also experienced by mental nurses who arise from excessive workloads and patient conditions that allow them to attack officers and often the nurse's personal protective equipment is detached so that this affects nurses in terms of nurses' psychology. This study aims to to explore the experience of mental nurses doing self-management in managing stress during the COVID-19 pandemic. Qualitative data were obtained through in-depth interviews with 16 participants at the Kalawa Atei Mental Hospital using a qualitative method with purposive sampling technique. The results of the study found 6 main themes, namely (1) Behavior of ODGJ patients while being treated, (2) The physical response of nurses when treating ODGJ patients with COVID-19, (3) Psychological responses when treating ODGJ with COVID-19, (4) Stress levels when treating ODGJ with COVID-19, (5) How to manage stress when treating ODGJ patients with COVID-19, (6) Successfully managing yourself in overcoming stress when treating ODGJ patients with COVID-19. The conclusion from this study is that nurses need an adaptation in managing stress by self-management in managing stress when providing care to patients.
Analisis Hubungan Beban Kerja dengan Kondisi Psikologis Perawat Relawan Covid-19
Authors: Apriyanti Firda , Afiyanti Yati , Firdaus Syamsul
Published: February 2022

Volunteer nurses are the frontline in performing COVID-19 treatment. They have a higher risk of exposure because they often interact with patients suspected or positive of COVID-19. The psychological condition is a mental condition that can influence the daily life of an individual COVID-19 volunteer nurses. If the psychological condition of individuals is hampered, it will influence their life, not only can ruin interactions or relationships with others but also decrease the work productivity of the nurse. The psychological condition of volunteer nurses is closely related to the workload of volunteer nurses because too much workload can cause tension in a person, causing stress, anxiety and depression and it can influence their role as COVID-19 volunteer nurses. This study aims to analyze the relationship between workload with the psychological conditions of COVID-19 volunteer nurses. The method in this study used a quantitative analysis design with a cross-sectional approach. The number of samples in this study was 200 COVID-19 volunteer nurses according to sampling technique referring to Maxwell theory (1999). This research was conducted throughout Indonesia. Data analysis used the Chi-square test. The instrument used was a questionnaire in the form of Google Form. The results of the study showed that there was a relationship between workload and psychological conditions of depression, anxiety, and stress on COVID-19 volunteer nurses
Estimating Potential for Drug Budget Reallocation Following Expiration of
Exclusivity of Pharmaceutical Products
Authors: Toghanian Samira , Moshtaghi-Svensson John , Papageorgiou Maria , Kittelsen Kristin , Dolk Christiaan , Hultstrand Markus , Salomonsson Stina
Published: February 2022

Background: The prioritization of public funds in an equitable and ethically sound manner along with efficient budget allocation are key challenges for governments and budget holders. Following the introduction of generics/biosimilars, the potential total budget made available for reallocation resulting from the loss of exclusivity (LOE) in a given market has not been estimated.

Objectives: This study investigated the impact of generic/biosimilar entry on drug budget in 4 countries.
Methods: Pharmaceutical sales data, drug costs and LOE dates were modeled and forecast using an analytical framework (Affordability by ReallocaTing Funds model [ART]) to estimate future incremental budget availability using scenario analyses in Greece (GR), the Netherlands (NL), Norway (NO) and Sweden (SW).

Results: During 2020-2022, 166 (GR), 222 (NL), 145 (NO) and 93 (SW) products facing LOE were identified. This equated to release of an estimated cumulative budget during 2020-2024 of €218 million (GR), €1319 million (NL), €340 million (NO) and €876 million (SW). The estimated average budget released per year during 2020-2024 was 1.8% (GR), 4.6% (NL), 3.4% (NO) and 3.9% (SW) of each country’s total annual drug budget.

Discussion: These analyses showed that LOE for pharmaceutical products between 2020 and 2022 can result in significant increase in budget availability. LOE in the retail channel was the main driver of budget availability in GR and SW, compared to LOE in the hospital channel in the NL and NO.

Conclusion: Estimation of future release of budget capacity using the Affordability by ReallocaTing Funds model supports discussion on resource allocation to fund innovation and may help inform policy changes.
In Fear of Black Revolutionary Contagion and Insurrection: Foucault, Galtung, and the Genesis of Racialized Structural Violence in American Foreign Policy and Immigration Law
Authors: Dodds Ciji
Published: February 2022

This article investigates the power relation between the political anatomy of the Black soul and non-somatic expressions of white supremacy-based violence. Utilizing Michel Foucault’s theories of discipline and punishment in conjunction with Johan Galtung’s theory of structural violence, I posit that the exercise of state-sanctioned discipline and punishment in furtherance of white supremacy constitutes racialized structural violence. Thus, this article contributes to the current public discourse concerning the role white supremacy plays in America by establishing a new construct that can be used to dissect the nature of racial oppression.

Furthermore, this article analyzes the genesis and construction of racialized structural violence in American foreign policy and immigration law using America’s response to the Haitian Revolution as a case study. When combined, akin to discipline, American foreign policy and immigration law is a white supremacy-oriented, complex bundle of power technologies designed to evoke docility from Black and Brown nations. Both allow America to engage in dissociative white supremacy. Over time, America’s “right” and power to discipline and punish Black and Brown nations has been normalized as a rational function of our global society.
Eaters, Powerless by Design
Authors: Pollans Margot
Published: February 2022

Food law, including traditional food safety regulation, antihunger programs, and food system worker protections, has received increased attention in recent years as a distinct field of study. Bringing together these disparate areas of law under a single lens provides an opportunity to understand the role of law in shaping what we eat (what food is produced and where it is distributed), how much we eat, and how we think about food. The food system is rife with problems— endemic hunger, worker exploitation, massive environmental externalities, and diet-related disease. Looked at in a piecemeal fashion, elements of food law appear responsive to these problems. Looked at as a whole, however, food law appears instead to entrench the existing structures of power that generate these problems.

This Article offers a novel conceptual critique of the food system. It argues that food law is built on two contradictory myths: the myth of the helpless consumer who needs government protections from food producers and the myth of the responsible consumer who needs no government protection and can take on the food system’s many problems herself. The first myth is self-actualizing, as the laws that it justifies disempower food consumers and producers. The second myth is self-defeating, as the legal structures that assume consumer responsibility impede meaningful consumer choice.

Food law, as it is shaped by these myths, constructs powerlessness by homogenizing— or erasing diversity within—the food system, paralyzing consumers through information control, and polarizing various food system constituents who might otherwise collaborate on reform. Ultimately, food law is designed to thwart food sovereignty. By revealing how the structures of food law itself obstruct reform, this Article also identifies a path forward toward true food sovereignty.
PENERAPAN METODE EXPLICIT INSTRUCTION UNTUK MENINGKATKAN AKTIVITAS DAN PRESTASI BELAJAR PENDIDIKAN AGAMA HINDU DAN BUDI PEKERTI
Authors: Windaresa Luh Putu , Suwendra I Wayan
Published: February 2022

Penelitian ini bertujuan untuk mengetahui Penerapan Metode Explicit Instructions dapat meningkatkan aktivitas dan prestasi belajar Pendidikan Agama Hindu dan Budi Pekerti pada siswa kelas X Multimedia SMK TI Bali Global Singaraja. Subyek penelitiannya adalah siswa kelas X Multimedia SMK TI Bali Global Singaraja dengan subyek penelitian berjumlah 14 orang. Penelitian ini dilakukan dalam dua siklus dengan teknik pengumpulan data melalui observasi, wawancara, pemberian tes yang diolah menggunakan analisis deskriptif kuantitatif.  Hasil penelitian ini menunjukkan bahwa terdapat kenaikan yang signifikan pada siklus I dan siklus II terkait aktivitas dan prestasi belajar Siswa kelas X Multimedia SMK TI Bali Global Singaraja sebagai berikut: Aktivitas Belajar pada siklus I sebesar 72,8% meningkat menjadi 81,7% pada siklus II pada katagori tinggi Untuk prestasi belajar yaitu : pada siklus I diperoleh nilai rata-rata kelas (M) sebesar 73,9% ,daya serap klasikal (DS) 73,7%, dan ketuntasan belajar klasikal (KB) 64,3%. Hal ini meningkat pada siklus II, yaitu nilai rata-rata kelas (M) 80%, daya serap klasikal (DS) 80%, dan ketuntasan belajar klasikal (KB) 85,7%.  Berdasarkan hasil tersebut direkomendasikan kepada para guru Agama Hindu agar dapat menggunakan metode ini dalam pembelajaran secara baik dan benar dalam rangka peningkatan kualitas proses dengan hasil belajar siswa.
ANÁLISE CINEMÁTICA DO CENTRO DE GRAVIDADE NO EXERCÍCIO AGACHAMENTO COM POSIÇÃO DA BARRA FRONTAL E COSTAL NAS TÉCNICAS PÉS PARALELOS E SUMÔ: UM ESTUDO TRANSVERSAL
Authors: Vilela Junior Guanis de Barros , Passos Ricardo Pablo , Garcia Júnior Jair Rodrigues , Carvalho Anderson dos Santos , Abdalla Pedro Pugliesi
Published: February 2022

O objetivo deste estudo foi analisar e comparar a biomecânica do agachamento em diferentes posições dos pés (sumô e paralelos) e da barra (dorsal e frontal). Método: Este é um estudo descritivo de observação transversal. A amostra foi intencional e composta por cinco sujeitos praticantes regulares de musculação há mais de um ano. A pesquisa foi aprovada pelo Comitê de Ética da UNIMEP sob Protocolo 2.697.591. Resultados: Nas comparações entre as técnicas de agachamento e posição da barra foi observado que os participantes executam as técnicas de agachamento aqui analisadas recorrendo a estratégias locomotoras distintas, fato que é confirmado pela variabilidade dos parâmetros cinemáticos. Conclusão: Constatou-se a variabilidade da posição do Centro de Gravidade existente entre as diferentes técnicas de agachamento analisadas (posição da barra [frontal e dorsal] e dos pés [paralelo e sumô]).
Analisis Perancangan Alat Pemetik Buah Mangga (LATIKMA)
Authors: Minaturrahim Husain , Afief Muhammad Rayhan , Firly Teuku Muhammad , Maulana Sofyan , Restianti Vika , Parwati Niken
Published: February 2022

Product development is something that is needed by every existing company. At this time, almost all companies are competing to continue to develop their products to attract consumers to be able to run life easily and comfortably. In this study, we analyzed the design of the LATIKMA (Mango Fruit Picker) to make it easier for people to pick mangoes and have other goals so that the mangoes that were picked were not crushed. This study using 4 methods, namely RPW, MRPW, LCR, and J. Wagon. With a total time of 147 minutes and the total time of all work stations being the same for the RPW method, the number of stations is 10, the line efficiency is 74%, and the smoothing index is 22.56, then for the MRPW, the number of stations is 10, the line efficiency is 74%, and the smoothing index is 22.56, then for the J. Wagon the number of stations is 10, the line efficiency is 74%, and the smoothing index is 30.14, and for the LCR method, the number of stations is 9, the line efficiency is 82%, and the smoothing index is 13.22.

Keywords - Product, OPC, Assembly Chart, Heuristic, Prototyp
Perancangan Kinerja Kepala Sekolah Menengah Atas dalam Perspektif Balanced Scorecard (BSC) Menggunakan Analytical Network Process (ANP) (Studi Kasus : SMA ABC Jakarta)
Authors: Sahar Rahmah Laila , Chirzun Ahmad
Published: February 2022

Education in the sense of schooling is now leading to the process of industrialization. The world of education can no longer be considered as a social institution only but must be treated industrially, which is treated or managed professionally. Due to the increasingly fierce world of competition today, if educational institutions are not managed professionally, then the customer will leave educational institutions if they are poorly managed. In various case studies, the Balanced Scorecard has provided many benefits to the development of education management, especially SMA ABC Jakarta does not yet have a performance measurement based on the Balanced Scorecard method. In the Balanced Scorecard method, the measurement is based on four perspectives, namely, financial, customer, internal business processes, and growth and learning perspectives. Therefore, a good performance design needs to be done to realize the vision of this ABC Jakarta High School. So, a performance design was carried out for the Principal of SMA ABC Jakarta using the perspective of the Balanced Scorecard method. Then, the weighting and prioritization of each KPI are carried out using the Analytical Network Process with the help of Super Desicion software. The results of this study are in the form of a Scorecard List, and there are 13 Principal KPIs from each perspective, namely 1 KPI from a Financial perspective, 9 KPIs from an Operational perspective, 2 KPIs from a Customer perspective, and 1 KPI from an HR perspective. Then, for the priority results of this KPI, it is found in the operational perspective, precisely on the KPI for the Implementation of Supervision of the Learning Process by Schools or O9 with a weight of 0.1992 or in the percentage of 20%, this indicates that the Implementation of Supervision of the Learning Process by Schools is the most important thing. compared to other KPIs.

Keywords - Analytical network process, Balanced scorecard, Perancangan kinerja, Software super decision.
Perancangan Model Penjadwalan Teknisi pada Perawatan BD Check Pesawat Airbus dengan Memperhitungkan Beban Kerja
Authors: Syafitri Adelia , Hidayat Syarif
Published: February 2022

PT GMF AeroAsia is engaged in the maintenance, repair, and overhaul (MRO) of aircraft. It is known that GMF is the largest domestic MRO company at 30% while 70% is owned by foreign MRO companies. Based on the company's vision to make the company a world-class MRO, it is necessary to develop a business scheme in terms of capability, quantity, and quality. However, the scheduling of technicians in carrying out aircraft maintenance is currently unable to meet the demand every hour due to the uncertain flight schedule of the aircraft every day so that the workload of each technician exceeds the normal workload. The calculation of the workload using the full-time equivalent method showed that the workload of technicians was overloaded so that an additional number of technicians was needed, as well as analyzing the causes and consequences of the excessive workload of technicians using the fishbone diagram method and modeling the formulation of the technician scheduling problem that works in maintenance before departure check Airbus aircraft in the form of integer linear programming with decision variables such as the number of technicians, the number of shifts and the number of working days, then the constraint function is the constraints to be achieved in modeling, and the objective function is to minimize the number of technicians employed. Furthermore, the model is implemented using the LINGO 19.0 software so that it is found that the model can produce an optimal technician schedule in scheduling.

Keywords - Fishbone Diagram, Full Time Equivalent, Integer Linear Programming, Lingo Software, Matchematical Modeling, Scheduling, Workload
The Role of the Parasite Life Cycle in Pathogenesis of Infectious Diseases
Authors: Trasia Reqgi First
Published: February 2022

Indonesia is a developing country that has various risk factors that can cause parasitic infections to develop. The role of the life cycle of worms and other parasites has been widely studied before. However, there is still little review of its pathogenesis in Indonesia. The purpose of this article is to examine the role of the parasite life cycle in the pathogenesis of infectious diseases. Based on this review, it can be concluded that Diphyllobothrium latum, Taenia solium, Echinococus granulosus, Hymenolepis nana, Dypilidium caninum, Schistosoma japonicum, Fasciolopsis buski, Heterophyes, Echinostoma, Clonorchis sinensis, Fasciola hepatica, Dicrocoemani, Paragon dencarisius, trichiura, Necator americanus, Ancylostoma duodenale, Stongyloides stercoralis, Trichinela spiralis, Angiostrongylus cantonensis, and Wuchereria bancrofti have different life cycles. This difference will have an impact on the different pathogenesis for each infection. Enforcement and treatment also differ based on the underlying pathogenesis.

Keywords – Life Cycle, Parasite, Patogenesis, Infectious disease
PEMDAMPINGAN PEMANFAATAN MEDIA PEMBELAJARAN BERBASIS OPEN DAN FREEWARE DI SMA PANCASILA TAMBOLAKA SUMBA BARAT DAYA
Authors: Erkamim Moh , Priyadi Sapto , Wati Vera
Published: February 2022

Pengabdian masyarakat ini bertujuan untuk untuk menambah pengetahuan dan pemahaman guru dan siswa di SMK Pancasila Tambolaka Sumba Barat Daya serta beberapa sekolah menengah lainnya,  mengenai penggunaan media online learning dalam proses pembelajaran selama pandemi Covid-19 yang mengharuskan pembelajaran dari rumah. Pengabdian masyarakat ini dilakukan di aula dan laboratorium komputer SMK Pancasila Tambolaka Sumba Barat Daya. Pengabdian ini berupa pelaksanaan pelatihan dan pendampingan pemanfaatan media online learning free google classroom dan gmeet. Pengabdian ini dihadiri oleh 28 peserta yang merupakan guru di SMK Negeri 1 Pancasila dan beberapa sekolah lainnya di Sumba Barat. Materi yang diberikan diantaranya Sosialisasi Pembelajaran, Penggunaan Google Classroom, Penggunaan Google Form,  Penggunaan Google Meet,  Semua Mapel dalam 1 Classroom dan Simulasi. Berdasarkan hasil evaluasi dari pelaksanaan pengabdian pada masyakat dengan pelatihan dan diskusi yang dilakukan selama 5 hari dapat diperoleh (1) media online learning free google classroom dan gmeet dapat digunakan oleh guru-guru, (2) alternatif solusi dalam menghadapi pembebelajaran yang mendadak online salam pandemi covid-19 (3) guru-guru telah berhasil menggunakan fitur-fitur pada media online learning free google classroom, google form dan gmeet. Berdasarkan dari hasil evaluasi dapat disimpulkan bahwa pengabdian pada masyarakat ini telah berhasil dilakukan dengan baik.
Pengembangan Modul Pembelajaran Matematika Berbasis Saintifik
Authors: Yulistiana Yulistiana , Rinaldi Achi , Fadila Abi
Published: February 2022

Penelitian ini bertujuan untuk: 1) Mengembangkan dan Mengetahui kualitas  modul pembelajaran matematika pada materi lingkaran berbasis saintifik ditinjau dari kevalidan dan keefektifan. Jenis penelitian ini adalah penelitian pengembangan prduk, berupa modul yang dikembangkan dengan berbasis saintifik.  Dalam pengembangan modul ini peneliti mengacu pada model pengembangan 4D yang terdiri dari 4 tahap  (Define, Design, Development, dan Disseminate) yaitu:  (1) Define yang meliputi observasi langsung pada siswa di lapangan, (2) Design yang meliputi penyusunan modul dari aspek isi, bahasa, saintifik yang disesuaikan dengan kebutuhan siswa, (3)  Development yang meliputi tahap pembaharuan produk awal yang telah diselesaikan dan kemudian diperbaiki, (4) Disseminate ialah tahap penggunaan prduk yang telah diperbaiki kemudian disebarluaskan ke lapangan., berdasarkan hasil angket respon siswa dan hasil evaluasi oleh ahli materi dan ahli media, efektif dengan ketuntasan hasil belajar yang sangat baik. Sehingga dapat disimpulkan bahwa modul pembelajaran matematika berbasis saintifik ini berhasil dikembangkan manjadi bahan ajar yang lebih baik karena telah disusun sesuai dengan kebutuhan siswa dan mampu memberikan kebermanfaatan bagi pembelajaran.
Към нов подход при оценка на лекарствата сираци в Германия
Authors: Искров Георги , Стефанов Румен
Published: February 2022

Традиционно, подходът при оценка на лекарствата сираци в Германия спада към т.нар. модел с фокус върху добавените здравни ползи. Това означава, че водещ критерий при вземане на решение за заплащане с публични средства е не разходната ефективност (както например е във Великобритания), а допълнителните здравни резултати на новата терапия спрямо алтернативата за сравнение. Привържениците на тази методология смятат за нейно основно предимство бързия достъп на пациентите до иновативни лечения, докато противниците й акцентират върху липсата на ефективен контрол върху разходите и цялостното бюджетно въздействие след това.

Оценката на лекарствата сираци в Германия се характеризира с друга особеност, характерна само за тази юрисдикция. Влезлият в сила през 2011 г. Закон за реформа на пазара на лекарствени продукти освобождава лекарствените терапии с орфанно обозначение от първоначална пълна оценка на здравните ползи. Вместо това, разрешението за пазарна употреба по централизираната процедура на Европейската лекарствена агенция служи като доказателство за наличие на добавени здравни ползи и съответно лекарствата сираци подлежат на съкратена процедура за ускорен достъп. Пълна оценка на тези здравни технологии е задължителна само когато определен лекарствен продукт надвиши 50 милиона евро обем на годишните продажби. В този случай вече, Институтът за качество и ефикасност в здравеопазването следва да извърши пълна оценка на здравните ползи, а Федералният съвместен комитет може да преразгледа решението си за достъп в светлината на представените доказателства. Десет години по-късно е време за равносметка.
Два клинични случая с мутация на ELMO2 ген, асоцииран с костни васкуларни малформации
Authors: Станчева Малина , Нетцер Кристиан , Майнтц Давид , Каракая Мерт
Published: February 2022

Костните васкуларни малформации представляват 0.2% от всички костни тумори. Описани са при 5 семейства в медицинската литература. Малформацията се характеризира с тежка и прогресивна съдова експанзия в костите на лицево-челюстната област, съпроводена понякога с дефекти на коремната стена като диастаза на мускулус ректус абдоминис и супраумбиликалния шев, в основата на които е нарушено RAC1 сигнализиране.

Авторите представят 3-годишно момче с български произход от четвърта патологична бременност с гестационен диабет, хидрамнион. Първите две бременности завършват с мъртвораждане на плод с церебрални кисти и сърдечни малформации, трета бременност – здраво дете. Пренатално в VII m.l. е диагностициран междупредсърден дефект, отворен форамен овале. След раждането се установява диастаза на мускулус ректус абдоминис. При ерупция на кучешките зъби се наблюдава значителен едем, кървене, гингивална хипертрофия, поява на лицев дисморфизъм с лицева асиметрия в мандибуларна, максиларна област и орбитата. КТ ангиографията на мандибулата показва артерио-венозна малформация. По време на опит за вземане на проба / ексцизия се наблюдава масивно кървене, което налага коли – емболизация, след което е отстранена аневризмална костна киста. Лечение със сиролимус е било проведено за няколко месеца. Осеммесечното по-малко братче на пациента е с умбиликална херния. Молекулярният анализ с NGS по Sanger установява при пациента и неговият по-малък брат патогенен хомозиготен вариант на ELMO2 гена (NM_133171: c.579_603dup, p.Leu202Profs*47. Двамата родители са носители на патогенен хетерозиготен вариант.
THE ROLE OF ORGANIZATIONAL CULTURE IN THE ACTIVITIES OF A COMPANY WITH FOREIGN INVESTMENT AND ITS MAIN CHARACTERISTICS
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russian Federation, Guseva A. V.
Published: February 2022

Organizational culture influences all levels of management and relationships within the workforce, which is especially important in multinational companies or in companies entering foreign markets, where the task of management is not only to build a strong and competitive organizational culture, but also to ensure that it did not conflict with the national cultural specifics of the employees. The essence of managing the organizational culture of an international corporation is to find a balance between the culture and values of the company and the national business culture of the country in which it enters the market.
Identifikasi Faktor Kegagalan Hasil Produksi Busa dengan Sistem Pakar Metode Dempster Shafer dan Certainty Factor
Authors: Lowrenza Dhyana
Published: February 2022

Foam is a derivative product made from PPG (Propylene Glycol) or Polyether Polyol which is then mixed with additives and catalysts. So it will produce foam that is used in the springbed and mattress industry. The foam is produced first by using a mixer machine. After the mixer, dispensing will be carried out (pouring the material into the mold) then the foam will be blown off and the foam production process is complete. Failure to produce foam often results in losses in terms of raw materials, costs, and time. To avoid the failure of the same foam production, a research was carried out by designing an expert system application that aims to be able to identify the factors causing the failure of foam production and to reduce the risk of failure of foam production. The data needed in this study were obtained from PT Bungo Permai Lestari. The data is then processed using the Dempster Shafer method and the Certainty Factor method. The results of this study are to provide output in the form of certainty values from failure of foam production, factors causing failure of foam production, as well as solutions to failure of foam production obtained through consultation using the Dempster Shafer method and the Certainty Factor method by selecting symptoms that match the results. foam production. So this research can help PT Bungo Permai Lestari to find out the causes and solutions to the failure of foam production and can reduce the risk of failure during foam production.
KEANEKARAGAMAN JENIS JAMUR MAKROSKOPIS DI HUTAN DESA TEWAH PUPUH KABUPATEN BARITO TIMUR
Authors: Leluni Sri , Sunariyati Siti , Panda Adventus
Published: February 2022

Jamur termasuk sel eukariotik yang tidak memiliki klorofil, tumbuh dari hifa, memiliki dinding sel yang mengandung kitin, bersifat heterotrof, menyerap nutrien melalui dinding selnya, dan mengekresikan enzim ekstraseluler ke lingkungan melalui spora, melakukan reproduksi seksual dan aseksual. Jamur makroskopis adalah jamur yang tubuh buahnya berukuran besar (berukuran 0,6 cm atau lebih besar), struktur reproduktif yang terbentuk untuk menghasilkan dan menyebarkan sporanya. Keberadaan jenis jamur di Hutan Desa Tewah Pupuh Kabupaten Barito Timur masih banyak yang belum diketahui dan tidak dibudidayakan. Kurangnya perhatian pemerintah daerah setempat terhadap keanekaragaman dan pelestarian merupakan alasan penting untuk dilakukannya penelitian. Penelitian ini juga bertujuan untuk mengetahui keanekaragaman jamur Makroskopis di Desa Tewah Pupuh dan diharapkan dapat membantu pembelajaran siswa di Sekolah Menengah Atas dalam Materi Keanekaragaman Hayati. Metode yang digunakan dalam penelitian ini adalah metode survei dengan teknik Purposive Sampling untuk menjelajah daerah yang terdapat jenis jamur, yaitu dengan dilakukannya pengumpulan data dengan menyusuri area Hutan Desa Tewah Pupuh dengan total luas area 240 m. Data yang dikumpulkan adalah jumlah jenis, jumlah individu jenis, dan jumlah kehadiran jenis. Data dianalisis menggunakan Indeks Keanekaragaman Spesies (species diversity), dan Indeks Nilai Penting (INP). Hasil penelitian mendapatkan 16 jenis jamur di Desa Tewah Pupuh, yaitu Lycoperdon pyriforme, Sarcoscypha coccinea, Polyporus sp., Hygrocybe sp., Fomes fomentarius, Mycena overholtsii, Mycena filopes, Thelephora sp., Pleurotus florida , Trametes sp., Cariolus sp., Daedalea sp., Ganoderma sp., Tricholoma sejunctum, Mycena melligena, Microporus sp. Indeks keragaman Jenis (H’) jamur sebesar 2,549. Berdasarkan indikator nilai H’, maka tingkat keragaman jenis jamur di Desa Tewah Pupuh Kabupaten Barito Timur termasuk dalam kategori keragaman sedang yaitu, H’ 1,5 ? H ?3,5. Indeks nilai penting (INP) yang tertinggi mencapai 49,938 % yaitu jenis Mycena melligena, Sedangkan jenis jamur dengan indeks nilai penting (INP) yang rendah yaitu, Mycena filopes dengan nilai (INP) 6,699 %.
Diversity of Echinoderms in Intertidal Zone of Sundak Beach, Gunung Kidul, Yogyakarta, Indonesia
Authors: Lesti Herin Yoga , Maharani Syifa Evilia , Rahmani Naila Nabila , Khalallia Fania Baeta Roska , Winasti Ni Made Sri , Huda Achmad Mustofa , Nafiah Septi Lutfiatun , Eprilurahman Rury
Published: February 2022

Indonesia is a maritime country with high diversity of marine biota, which one is from Phylum Echinoderms. Echinoderms are known as biota of marine which is are living on corals, sandy, and on the intertidal zone and deep ocean. The intertidal characteristics of Sundak Beach has a suitable structure to echinodems life because there are many corals, but there is many species has not been identified before. The purpose of this research is to know the diversity of echinoderms phylum on the intertidal zone. Sampling was carried out on August, 24th 2019 with purposive random sampling method along the coastal-line in intertidal zone. The result of this research are identified and classified on the each class. Based on the results, the are found species from Echinodea, Holothuroidea, and Ophiuroidea. Species from Echinoidea are Tripneustes gratilla, Echinometra mathaei, Heterocentrotus trigonarius, Diadema antillarum., and Echinothrix calamaris. Holothuroidea namely Holothuria atra. Ophiuroidea namely Ophiotrix fragilis, Ophiocoma scolopendrina, and Ophiocoma erinaceus. The conclusion from this study is the discovery of five species from class Echinoidea, one species from class Holothuroidea and three species from class Ophiuroidea.
Multimodal radiological assessment of myocardial viability in patients with ischemic heart disease
Authors: Kundina V. , Babkina T.
Published: February 2022

Purpose of the study – to determine the radiological indicators of the effectiveness of myocardial revascularization in patients with coronary artery disease.
Material and methods. For the implementation of the clinical objectives, 62 patients with ischemic heart disease, heart failure, with preserved systolic function and systolic dysfunction were examined. The patients' age ranged from 40 to 79 years, the average age of the examined was 59.6 ± 8.2 years. 35 (56 %) patients had HF with LV systolic dysfunction with EF of 49 % or less. 27 (44 %) patients had preserved systolic function - ejection fraction greater than or equal to 50 %. Among the studied patients, 5 patients (8.0 %) denied the presence of myocardial infarction. The vast majority of patients (50 patients; 80.7 %) had one myocardial infarction (MI), 7 patients (11.3 %) had two MI. In 5 patients from the group of suffered infarctions, MI without pathological Q wave was recorded anamnestically, and in 52 patients – transmural MI.
Results. In the group before treatment, the values of myocardial viability were 69.4 % CI 95 % [65.3 %; 73.5 %], rest-score 18.1 CI 95 % [16.2; 18.0 %], end-diastolic volume (EDV) 147.1 CI 95 % [128; 163.2], systolic thickening of the left ventricle 39.4 CI 95 % [35.9; 43.0], LVEF 40.2 CI 95 % [35.9; 44.6], and after treatment the value of myocardial viability was 75.0% CI 95 % [70.8%; 79.3 %], rest-score 12.5 CI 95 % [10.3; 14.6 %], EDV 132.5 CI 95 % [113.9; 151.1], systolic thickening of the left ventricle 41.4 CI 95% [38; 44.8], LVEF 40.4 CI 95 % [36.5; 44.4].
Conclusion. Thus, the conducted study allowed us to identify functional indicators of the effectiveness of the performed surgical treatment by the method of coronary artery bypass grafting in patients with coronary artery disease. We obtained the registered significance in: myocardial viability (p = 0.0000), end diastolic volume (p = 0.0142) and systolic thickening of the left ventricle (p = 0.0146).
Key Words: coronary artery disease, revascularization, myocardial scintigraphy, myocardial viability, coronary artery bypass grafting
Artificial Intellect, Radiomics and Radiogenomics
Authors: Dykan I. , Kolotilov N.
Published: February 2022

Artificial intellect (AI) is a complex of technological solutions that allows simulating human cognitive functions (including self-learning and finding solutions without a predetermined algorithm) and obtaining, when performing specific tasks, results comparable, at least, to the results of human intellectual activity. The most promising area of AI in medicine, in which technologies have achieved obvious success and are already being actively applied, is the analysis of diagnostic images (X-ray, MRI, CT, PET, SPECT): detection, recognition and identification of various pathologies on them.
The purpose of the review is to guide the reader in the potential and problem of AI technologies in radiation diagnosis of human pathologies. The review covers articles that meet the following criteria: the publication is an original research article; the publication is devoted to radiation diagnostics; the publications analyze the use of AI technology in solving the clinical problems of diagnosis, prognosis of a particular pathology; radiology is a potential or actual field of the AI technology application analyzed in the publication.
The problem of data verification and marking, radiomics and radiogenomics (as a basis for machine and deep learning of AI), the use of AI in hepatology, limitations and risks of AI application in medicine are considered.
Magnetic Resonance Spectroscopy: Information and Efficiency of Diagnostics of Malignant Tumors (Review and Portfolio)
Authors: Ternovoy N. , Drobotun O. , Kolotilov N. , Tuz E. , Vovk V.
Published: February 2022

The potential field of magnetic resonance spectroscopy (MRS) application in the clinical practice of oncology is trivial: differential diagnosis of tumors, analysis of tumor malignancy degree, visualization of tumor response to chemotherapy, radiation therapy, and prediction of treatment outcome.
The purpose of the work is to present, within the framework of infographics, the initial visual data of MRS of malignant tumors of various localizations for promising multiplatform systems of scientific visualization. Recall that scientific visualization deals with issues of accurate and understandable display of objects, processes and phenomena of scientific/practical interest.
In the aspect of infographics, representative spectra of normal and tumor of brain tissues, auditory nerve, thyroid gland, lungs, mammary gland, pancreas, liver, kidneys, ovaries, uterus, prostate gland, muscles, and bones are presented.
The main defined 1H-MPC tumor metabolites are described. Many tumors are overlapped in spectrum, and MRI results are best interpreted in conjunction with other imaging and histological analysis findings. The potential of MRS technologies can be fully realized only in superposition with artificial intellect.
Fluid Inclusion and Titanite U-Pb Age Constraints on the Yuanjiang Ruby Mineralization in the Ailao Shan-Red River Metamorphic Belt, Southwest China
Authors: Huang Wenqing , Ni Pei , Zhou Jungui , Shui Ting , Pan Junyi , Fan Mingsen , Yang Yulong
Published: February 2022

The Yuanjiang marble-hosted ruby deposit lies in the central segment of the Ailao Shan metamorphic massif of the Ailao Shan-Red River metamorphic belt. The mineralizing fluid and age were characterized by detailed petrography, Raman spectroscopy, microthermometry, and in situ titanite laser ablation-inductively coupled plasma-mass spectrometry dating. Some fluid inclusions in the corundum show an interesting morphology with a diaspore crystal fully separating the whole inclusion into two smaller inclusions. This morphological feature can be explained by morphological ripening and subsequent reactions between the trapped H2O and the host corundum during the cooling of the inclusion. Fluid inclusions in the ruby belong to the system CO2–H2S–COS–S8–H2S2–CH4–AlO(OH) with various daughter minerals, including diaspore, gibbsite, and native sulfur (S8). The observed seven-component fluid inclusion composition can be explained by two steps: (1) original fluid inclusion capture during deposit formation with compositions including CO2, H2S, COS, CH4, S8, and H2S2, and (2) post-entrapment fluid inclusion modification, such as diaspore and gibbsite. The presence of hydrous minerals in fluid inclusions strongly supports the idea that water was once present in the initial fluids.

In the Yuanjiang deposit, petrographic evidence shows that titanite formed simultaneously with ruby, and U-Pb dating of titanite allows us to conclude that the ruby mineralization formed at 23.4 ± 0.3 Ma, in other words during the Himalayan orogeny.
Bioerosion in the carbonate budget of two Indo-Pacific reefs: La Réunion (Indian Ocean) and Mooréa (Pacific Ocean)
Authors: Clausade M. Peyrot , Pari N. , Chazottes V.
Published: February 2022

On coral reefs, products of bioerosion through the activity of micro- and macro-boring organisms and grazers are particulate and dissolved carbonate. The con-tribution to bioerosion of the major boring and grazing species was estimated on French Polynesia and the island La Réunion. The influence of bioerosion on the calcification/dissolution budget of reefal waters and on particulate calcium car-bonate fluxes was investigated. Studies on bioerosion were performed in order to assess: (a) eroding activity of grazers through the gut content analysis of echinoids and scarid parrot fish, (b) eroding activity of micro- and macroborers from ex-perimental substrates exposed for one year, and (c) role of sponges in total bioero-sion on reefal and experimental substrates. Calcification/dissolution budget was measured using the alkalinity anomaly technique, and particulate carbonate pro-duction was analysed from trapped sediments.
Relasi Hafalan al-Mufradāt atas Keterampilan Berbicara
Authors: Azizah Siti Fatimatul , Sholihah Rizki Amalia , Wijayanti Lisma Meilia
Published: February 2022

The ability to memorize vocabulary which is a person's effort to be able to do something to memorize vocabulary as much as possible. This memorization ability will affect a person's ability to speak Arabic. The level of language development starts from screaming, sporadic babbling, systematic babbling evidenced through imitation and speech. This type of research is quantitative. The purpose of this study was to determine the ability to memorize vocabulary and Arabic speaking skills of KMI’s student Arrisalah Islamic Boarding School Ponorogo. The selection of this research design always refers to the hypothesis which will later enter the resistance test. This study used a limited population that was heterogeneous because the population was less than 50 people. This study used test, documentation, and observation techniques in the data collection. The data analysis technique of this research used the product-moment correlation technique. Meanwhile, to analyze the results of the study the normality test, linearity test, and paired sample t-test were used. The results of this study indicate that there is a significant relationship between the ability to memorize mufradat and Arabic language skills. This is evidenced by the results of the value of Sig. (2-tailed) 0.000 <0.05.
Korelasi antara Penguasaan Mufradat, Bi'ah Lugawiyyah, dan Mahārah al-Kalām Santri Al-Izzah Leadership School Batu
Authors: Shobirin Abdurrahman
Published: February 2022

This research is a correlational study that looks for the relationship between arabic vocabulary mastery, language environment, and arabic speaking skills among students of al-Izaah Leadership School Sumberjo, Batu. The problems found are as follows: (1) The lack of knowledge of students' vocabulary in communicating using Arabic, (2) The number of students who enter the language court is due to Javanese and language that is not by the nature of education, (3) several students are hesitant to use the vocabulary that has been given and nervous when evaluating orally. The results showed that there was a significant relationship between arabic vocabulary mastery, language environment, and arabic speaking skills because the significance value (Sig.) 0.011 was smaller than 0.05 (0.011 < 0.05), and t count was 5.597 greater than F. table N = 25 with a value of 4.240 (5.597 > 4.240). The contribution of arabic vocabulary mastery is 32.3%, and the gift of the language environment is 0.2%. The low contribution of these two variables impacts the soft arabic speaking skills produced among students of al-Izzah Leadership School Sumberjo, Batu, which is 33.7%. The more negligible contribution to arabic vocabulary mastery and the language environment, the resulting arabic speaking skills become smaller.