P-1076. Describing the clinical characteristics, treatment patterns, and outcomes in hospitalized pneumonia patients treated with Ceftolozane/Tazobactam (C/T): Insights from the SPECTRA Study
Authors: Yucel Emre , Soriano Alex , Paterson David , Thalhammer Florian , Kluge Stefan , Viale Pierluigi , Allen Mike , Akrich Brune , Zhou Yanbing , Yang Huina , Kaul Sundeep 
Published: January 2025

Background

This sub-analysis of the SPECTRA (Study of Prescribing patterns and Effectiveness of Ceftolozane/Tazobactam [C/T] Real-world Analysis) study aimed to describe the clinical characteristics, treatment patterns, and outcomes of hospitalized pneumonia patients treated with ceftolozane/tazobactam (C/T).Table 1.Patient characteristics and Microbiology2 Immunocompromised defined as: ‘Immunocompromised present’ [raw item] or ‘Hematologic Malignancy present’ or ‘Solid Tumor present’ or ‘Transplant=Yes’.

Methods

SPECTRA was a multicenter observational study conducted in 7 countries. It included adult patients (age≥18yrs) who received ≥48-hours C/T treatment (n=617). Retrospective data were extracted from medical records covering a 6-month period prior to the index date, up to 30 days after the last dose of C/T or until death. Descriptive statistics were used to analyze clinical success, all-cause in-hospital mortality (ACHM), intensive care unit (ICU) admission, length of stay (LOS) in the subcategory of pneumonia (n=182).Table 2.Outcomes with Ceftolozane/tazobactam and Treatment duration (days) (Treatment interruptions not included)*Other conditions: Bile duct anostomic leakage, Brain-vascular hemorrhagic accident, CMV infection, Encephalic Death, Hemorrhage, Invasive fungal infection, Necrotizing pancreatitis, Post operative complication, Renal amyloidosis, Spontaneous rupture of the spleen, Septic shock, Hemodynamic dysfunction, Kidney failure, Stable angina grade I-II CCS, Probable Clostridium difficile colitis, Progression of AML, Refractory Hypoxemia, Refractory hematologic malignancy, Subarachnoid Hemorrhage, Solid tumor, Tracheobronchitis

Results

The median duration of C/T treatment was 11.0 days, median time from index hospitalization admission to C/T initiation was 19.0 days, and from the first microbiological sample to C/T initiation 6.0 days. All-cause in-hospital mortality was 32.4% (n=59), with a median time from the index to death of 28.0 days. The causes of death included sepsis (38.9%) and pneumonia (18.6%) and 67% (n=122) patients were admitted to the ICU during the index hospitalization. Pseudomonas aeruginosa (PSA) was the most commonly isolated pathogen (88% of patients), with MDR PsA present in 68.4% (n=80) of pneumonia patients.

Conclusion

In hospitalized patients with pneumonia treated with C/T in a real-world setting, clinical characteristics, treatment patterns, and outcomes provide insights into the use and effectiveness of C/T.

Disclosures

Emre Yucel, PhD, Merck: I am a full time Merck Employee and own stocks in the retirement plan provided by Merck.|Merck: Stocks/Bonds (Public Company) David Paterson, bioMerieux: Grant/Research Support|bioMerieux: Honoraria|Merck: Advisor/Consultant|Merck: Grant/Research Support|Merck: Honoraria|Pfizer: Advisor/Consultant|Pfizer: Grant/Research Support|Pfizer: Honoraria|Shionogi: Grant/Research Support|Shionogi: Honoraria Florian Thalhammer, MD, MSD: Advisor/Consultant Stefan Kluge, Prof. Dr. med., Merck & Co: Advisor/Consultant|Merck & Co: Board Member Mike Allen, PhD, Merck: I am a full time Merck Employee and own stocks in the retirement plan provided by Merck.|Merck: Stocks/Bonds (Public Company) Brune Akrich, MD, Merck: I am a full time Merck Employee and own stocks in the retirement plan provided by Merck.|Merck: Stocks/Bonds (Public Company) Yanbing Zhou, PhD, Merck: I am a full time Merck Employee and own stocks in the retirement plan provided by Merck.|Merck: Stocks/Bonds (Public Company)