bluuebunny/crossref_metadata_2025 huggingface dataset:
Students Perceptions of Homework as a Formal Assessment Method
Authors: MUTLU Volkan
Published: August 2021

Whether it is formative or summative, an assessment which is explained in Oxford Advanced Learner’s Dictionary (2015) as “an opinion or judgement about sb/sth that has been thought about” (p.75) plays a significant role in completing the language education process because of its ability to provide feedback. Choosing the right assessment method is crucial for language teachers since most classical assignments create anxiety and make the process problematic for the students. Whether the classical assignments evaluate the students’ knowledge, or they understand that their grammar level for a definite time is another discrepancy to clarify. By taking into consideration those, this qualitative study focuses on the problems of classical exams and tries to reveal how beneficial and desirable can a difficult homework be as a formal assessment method. An unstructured interview form was used to collect data from 40 prep-class students who were selected using a convenience sampling method to understand their perceptions about homework as a formal assessment method. Results showed that although 32 of those students had difficulties while preparing the homework, most of them liked the process as well and think that this kind of homework is more beneficial than classical exams. Moreover, more than half of the participants’ desire to have such homework instead of classical exams despite homework’s difficulties, and they also express that this homework increased their language knowledge.
The second case of Noonan syndrome: The association with unique multiple cardiac defects
Authors: Al Mosawi Aamir Jalal
Published: August 2021

Background: Noonan syndrome is a heterogeneous congenital disorder that can occur sporadically or inherited as an autosomal dominant disorder. It is characterized by a wide spectrum of phenotypic abnormalities that vary greatly in range and severity, and two patients with Noonan syndrome may have two different characteristic features. In many patients the syndrome characterized by craniofacial abnormalities including low set ears, hypertelorism , congenital heart defect, short stature, and undescended testes. Although pulmonary stenosis is the commonly associated congenital cardiac defects, a variety of cardiac defects may occur in this syndrome. Atrial septal defect, and patent ductus arteriosus are other well-recognized cardiac defects of this syndrome. The diagnosis of Noonan syndrome is entirely clinical as there is no specific diagnostic available Materials and methods: A ten month old boy who was referred to the pediatric neuropsychiatric clinic of the Children Teaching Hospital of Baghdad Medical City because of developmental delay associated with multiple congenital abnormalities was studied. Results: The boy had growth and developmental retardation, low set ears, hypertelorism, and smooth philtrum, undescended testes. Echocardiography showed interatrial septum, small atrial septal defect and closing patent ductus arteriosus. Conclusion: Noonan syndrome was previously reported only in one girl from Iraq. The first Iraqi boy with Noonan syndrome is reported in association with unique cardiac defects. The previously reported case and the case in this deport demonstrates the variability of the phenotype of this syndrome.
Severe gastrointestinal bleeding secondary to cholecystitis: a case report and our handling experience
Authors: Zhou Hong-Kun , Yu Hao , Wang Jia-Yi , Chen Yu-Xing , Kang Yong-Li , Wang Li-Zhang , Wu Fan
Published: August 2021

The patient was male, 57 years old, who was treated for "upper abdominal pain and discomfort for 4 hours". The pain was severe, with back radiation, without cold fever, nausea, vomiting, chest tightness, shortness of breath, skin or yellow eyes, also without hematemesis or black stool. Physical examination: without yellow skin and sclera, with right upper abdomen tenderness and positive Murphy sign. There were no other obvious positive signs. Abdominal CT：cholecystitis with possible occupancy, and multiple common bile duct stones. Laboratory tests: White blood cells was 10.88×109/ L, neutrophilic granulocyte was 84%, Glutamic transaminase was 666 IU/L. Past medical history: hypertension and diabetes. Preliminary diagnosis: Acute cholecystitis, Common bile duct stones, Abnormal liver function, High blood pressure, Diabetes, Admitted to hospital. Handling measures: fasting, pain relief, anti-infection, liver protection, fluid replacement treatment, and monitor blood sugar, blood pressure, and further improve the inspection.
ANALISIS KINERJA PRODUKSI INSTALASI PENGOLAHAN AIR I PADA PERUSAHAAN DAERAH AIR MINUM (PDAM) BANDARMASIH DENGAN MENGGUNAKAN METODE OBJECTIVE MATRIX (OMAX)
Authors: Parhani Parhani , Marsudi Muhammad , Muttaqin Idzani
Published: August 2021

Abstrak-PDAM merupakan Badan usaha milik daerah yang termasuk dalam kategori pelayanan jasa dengan tugasnya memberikan pelayanan air bersih kepada masyarakat. Sebagai instansi pemerintahan yang bertanggung jawab untuk memberikan pelayanan masyarakat, maka untuk melihat kualitasnya dilihat dari proses kinerjanya dalam penyedia air bersih dalam produksi instalasi pengolahan air . Kinerja di sebuah perusahaan sangat penting dibutuhkan, terutama dalam Perusahaan Daerah Air Minum (PDAM) Bandarmasih pada bagian produksi instalasi pengolahan air. karena dengan adanya kinerja, Perusahaan dapat mengukur sejauh mana perkembangan usaha yang sudah dijalankan karyawan sesuai tanggung jawab masing.masing. Perumusan masalah dalam penelitian ini adalah bagaimana kinerja yang ada dalam Perusahaan Daerah Air Minum (PDAM) Bandarmasih pada bagian produksi Instalasi Pengolahan Air. Dalam penelitian ini yang menjadi objek penelitiannya adalah penggunaan metode Objective Matrix (OMAX) pada perhitungan bahan baku utama, bahan baku pendukung, tenaga kerja, jam kerja dan tenaga listrik pada Perusahaan Daerah Air Minum. Kata kunci: Kinerja produksi, PDAM Bandarmasih, Metode Objective Matrix (OMAX).
Notes on nomenclature and distribution of some Palaearctic Pentatomidae (Heteroptera)
Authors: Kerzhner I.M.
Published: August 2021

Eurydema dominulus montana Kerzhner, 1972 is considered a separate species (stat. n.). Two tentative synonymies are proposed: Sciocoris macrocephalus Fieber, 1851 = ? S. europaeus Amyot & Serville, 1843; Staria lunata (Hahn, 1835) = ? Cimex impressus Gravenhorst, 1807. Some nomenclatural problems are discussed and some new records of species are included.
Lygus poluensis Wagner and its synonyms (Heteroptera: Miridae)
Authors: Aglyamzyanov R.S.
Published: August 2021

Examination of the type specimens of Lygus poluensis revealed the following new synonymy: L. poluensis (Wagner, 1967) = L. dracuncili Josifov, 1992 = L. renati Schwartz, 1998 (new name for L. elegans Aglyamzyanov, 1994).
The Geographical Extent of Azania
Authors: Chami Felix
Published: August 2021

The Romans identified East Africa as Azania. The Chinese as Zezan. The metropolis of Rhapta was indicated to be the capital of Azania. In recent times a controversy emerged as to the location of Azania and Rhapta. A discussion has also occurred regarding the kind of people who settled in Azania. Whereas some scholars agree that the core of Azania was in East Africa modern, the geographical extent of Azania is in question. Archaeological, historical, and linguistic data have been used to suggest Azania extended from the coast of East Africa to the Great Lakes region, central Africa and South Africa. It is also argued that the people of Azania were Bantu speakers who were farming and smelting iron. It is therefore justifiable for the people of the larger region of South Africa to East Africa to name themselves Azanians.
The Effects of Human Mobility Restriction During Covid-19 Pandemic to Indonesia's Economy
Authors: Fadly Ferdian
Published: August 2021

In response to the coronavirus disease 2019 (COVID-19) pandemic, several national governments have implemented lockdown restrictions to reduce the risk of infection. However, this will have an impact on the economy of a country, including Indonesia. This study will analyze the effect of mobility restrictions on the economic growth in Indonesia during the pandemic in 2020. The data used are real-time data on community mobility report provided by Google. Data processing begins with factor analysis, followed by multiple linear regression. This study aims to model the changes in community mobility as exogenous factors affecting economic growth. As a result, restrictions on community mobility, particularly related to job factors, significantly affect the economic development of an area, particularly in the provinces of Java Island. The resulting model would explain 96.97 per cent of the variations in regional economic growth in Indonesia in 2020. Besides, this study predicts that 25 provinces will experience a recession in the third quarter of 2020. This forecast is the result of economic growth estimated using the current condition. Learning the association between mobility and economy is essential to understand how much restrictions or relaxations needed that can be appropriate to our economy during the pandemic.
Determination of the average intraocular pressure values, optimum anesthesia dose and phenotypic characteristics in Oscar fish (Astronotus ocellatus)
Authors: YAŞAR Tuba Özge , YARDIMCI Mehmet , YAĞCILAR Çetin
Published: August 2021

This research was carried out to determine the intraocular pressure values, optimum anesthesia dose and phenotypic characteristics in Oscar fish (Astronotus ocellatus). A total of 11 adult, male Oscar fish were used in the study. Optimum anesthesia dose, pre-and post-anesthesia intraocular pressure values and phenotypic measurements (total length, fork length, standard length, dorsal fin base length, head length, body length, eye diameter, body depth, pectoral length, pelvic fin bottom length, anal fin bottom length) were determined and reference values specific to this fish species were obtained by performing a statistical analysis. When exposed to 3 cc/L of the concentrations, fish achieved a deep state of anesthesia (induction time 1.31 min; recovery time 6.42 min). The most balanced anesthesia without risking vital functions was achieved using Clove oil with a dose of 2.5 cc/L. Compared to the other dimensions, total length, fork length and standard length were the most consistent body measurements with high positive correlations. No statistically significant difference (p > 0.05) was seen in both eyes between the intraocular pressure values before (5.36-5.86) and after (5.59-5.36) anesthesia. It is recommended that the ideal concentration of clove oil was 2.5 cc/L to reduce stress and injury damage during handling procedures. Additionally, intraocular pressure values, body measurements and Clove oil optimum anesthesia dose obtained in this study can be used as reference values for Oscar fish raised in aquarium conditions.
Telling People to Change Their Behaviour Through Implications: An Implicature Analysis on Covid-19 Public Service Announcements in Indonesia
Authors: Marbun Susan , Silalahi Dumaris E. , Herman Herman
Published: August 2021

Public service announcements (PSAs) are the official way for governments to inform, educate and change public behaviour in order to reduce public health issues, such as Covid-19. This study aims to analyse the types of implicatures in the Covid-19 PSAs published by the Ministry of Health Republic of Indonesia in their Instagram account, @kemenkes_ri, in order to fill the research gap on implicature studies in a public health and political contexts. This qualitative descriptive research analysed a data of eleven Covid-19 PSAs which were published from March 2020 to January 2021 according to Grice’s implicature theory. The researchers discovered that PSAs employed conversational implicatures more frequently than conventional implicatures (18%) to deliver their messages, with generalised conversational implicature being more prevalent (64%) than particularised conversational implicature (18%). Conventional implicature was used only in earlier posts when Covid-19 has not been a common knowledge among the public, and once people are already used to the “new normal”, alter PSAs used conversational implicature because the public already have the context of Covid-19. Results of this study illuminated the differences between each type of implicatures and also contributed to the lack of studies of PSAs’ implied meanings, the dearth of implicature studies in a non-classroom context.
SENTIMENT ANALYSIS OF CUSTOMER REVIEWS
Authors:   St. Xavier’s College (Autonomous), Kolkata, Rashiq Nazar Syed , Bhattasali Tapalina
Published: August 2021

Sentiment analysis is a process in which we classify text data as positive, negative, or neutral or into some other category, which helps understand the sentiment behind the data. Mainly machine learning and natural language processing methods are combined in this process. One can find customer sentiment in reviews, tweets, comments, etc. A company needs to evaluate the sentiment behind the reviews of its product. Customer sentiment can be a valuable asset to the company. This ultimately helps the company make better decisions regarding its product marketing and improving product quality. This paper focuses on the sentiment analysis of customer reviews from Amazon. The reviews contain textual feedback along with a rating system. The aim is to build a supervised machine learning model to classify the review as positive or negative. As reviews are in the text format, there is a need to vectorize the text to numerical format for the computer to process the data. To do this, we use the Bag-of-words model and the TF-IDF (Term Frequency-Inverse Document Frequency) model. These two models are related to each other, and the aim is to find which model performs better in our case. The problem in our case is a binary classification problem; the logistic regression algorithm is used. Finally, the performance of the model is calculated using a metric called the F1 score.
Digital sets: power and subjectivity in the era of new media
Authors: Feigelman Artem
Published: August 2021

This paper is a reply to Evgeniy Maslanov’s article “Challenges of Digitalization for Technogenic Civilization”. Emphasizing the total impact of digitalization on modern society, the author tends to agree with E. Maslanov that at the moment human existence is proceeding in a hybrid mode, for which the “real-virtual” dichotomy seems irrelevant. Being in this mode, a person leaves a digital footprint on the network, which forms her or his digital identity. The latter turns out to be “transparent”, vulnerable to instrumental influence from outside. Digital footprints are totalized into gigantic amounts of big data that can be used for social manipulation, as evidenced by the Cambridge Analytica case study. The manipulative activity of Cambridge Analytica fits into the context of the post-truth policy, which tends to ignore the facts in favor of false information that brings pragmatic benefits to the subject of the statement. This article argues that the complexity of social dynamics characteristic of the digital age is balanced by new means of description and analysis that enable us to better understand and navigate modernity. Nevertheless, a total description and thus stabilization of social reality seems impossible, given its advantageously network nature. The flip side of digitalization includes increased control within labor relations, blurring the boundaries between work and home as blurring the distinction between the “real” and the virtual. Along with it, the digital space is becoming a space of emancipation, where individuals-singularities form sets freed from violent unity (in the terms of Michael Hardt and Antonio Negri). The multitudes unfold their subjectivity in opposition to the social system, to which they oppose networked col-lective action and solidarity. The article concludes about the dialectical role of digitalization, which can serve as both a means of control and a means of emancipation. Thus, the challenges of digitalization seem not so much a technological call as a social one.
About trust in Google, and more
Authors: Shibarshina Svetlana
Published: August 2021

This text is a reply in the discussion about the challenges of digitalization for the technogenic civilization. In the context of the general problematic field of reflections initiated by Evgeniy Maslanov, the author focuses on the power of algorithms starting from M. Foucault’s concept of power and correlating it with the actor-network theory and John Urri’s thought on path dependence. The author suggests a few examples of how algorithms collect, compare and analyze user behavior in the Internet space (also with reference to the research of M. Kosinski), demonstrating how all of these allow to reconstruct an amazingly accurate digital portrait of a particular individual.
“Biocapitalism” without “bio-...”: the vanishing vitality and three dimensions of desynchronization
Authors: Shevchenko Sergei
Published: August 2021

The term “biocapitalism” commonly means “commodification of life”. As a critical tool, it is an important part of the rhetorical apparatus that denounces the “neoliberal (bio)economy” and relations of its elements: human bodies, cells and tissues, biotech companies and stock markets. However, sociologists K. Birch and D. Tyfield in a series of studies attempted to discover the mass practices denoted by this term – “biocapital” practices dealing with materiality of living objects, as well as the observed bio-economic processes. As a result, they failed to form a consistent idea of biocapitalism and related bio-concepts (bioeconomics and biovalue). This article makes an attempt to reveal this inconsistency through the conceptualization of contradictions of biocapitalism. These contradictions seem to have emerged most acutely in the context of the COVID-19 pandemic. In this article, they are described as three types of desynchronization: between the public and the private, between capi-talism and the “free market”, and between “internal” and “external” biological threats. Desynchronization in the general sense is understood as a produced lack of simultaneity, a fabricated anachronism. For example, “private” life of people looks like anachronism in the background of the “public” dimension of the pandemic, etc. At the same time, within the framework of desynchronization, it is impossible to detect directly either “commodification of life” or what could be called the expectations of a capitalist society from the biotechnology. In this regard, we can say that biocapitalism is realized through the exclusion of both life itself (vitality) and a good human life. I am trying to demonstrate this by pointing out two cases that can be designated as the falling out of “bio-...” from “biocapitalism”.
Delta-like ligand 4 level in colorectal cancer is associated with tumor aggressiveness and clinical outcome
Authors: Zhang Zixi , Li Xiao , Yan Xueli , Qiu He , Li Gai , Guo Xiaowen , Lu Yan , Yang Jingyi , Jiao Min , Chen Xue , Zhu Shaojun , Dang Chengxue , Wang Weizhong , Chu Dake
Published: August 2021

BACKGROUND: The Notch signaling regulates numerous cell growth, differentiation, and death. However, the expression pattern of its ligand Delta-like 4 (DLL4) in tumors is still uncertain. OBJECTIVE: In the present study, we examined DLL4 expression in colorectal cancer as well as assessed its role as a prognostic indicator in the present study. METHODS: DLL4 expression was examined by immunohistochemistry in 289 surgically resected specimens of colorectal cancer and adjacent normal tissues. The relationship between DLL4 expression and clinicopathological characteristics was analyzed. The association of DLL4 expression with the patients’ overall survival rate was assessed by Kaplan-Meier and Cox proportional-hazards regression. RESULTS: Increased DLL4 level was detected in colorectal cancer compared with that of normal tissues. Elevated DLL4 level in colorectal cancer was associated with increased body mass index of patients. Moreover, increased DLL4 level was also found to be correlated with tumor invasion, metastases and unfavorable clinical outcom of patients. CONCLUSIONS: DLL4 level is increased in colorectal cancer, especially in patients with increased body mass index, indicating potential involvement of obesity-related tumorigenesis and development. It might also serve as a novel molecular marker to predicate outcome of patients.
LINC01207 promotes the progression of non-small cell lung cancer via regulating ARHGAP11A by sponging miR-525-5p
Authors: Zhang Bin , Jin Zhou , Zhang Hao
Published: August 2021

BACKGROUND: The disorder of LINC01207 has a significant regulatory effect on cancers, nevertheless its role in non-small cell lung cancer (NSCLC) have not been illustrated. This study investigated the regulatory effect of LINC01207 on NSCLC and clarify its molecular mechanism. METHODS: Bioinformatics analysis was used to find the target lncRNA, miRNA and mRNA. LncBase and TargetScan databases predicted the relationship between LINC01207, miR-525-5p and ARHGAP11A. Dual-luciferase reporter gene assay and RNA binding protein immunoprecipitation assay were used to verify the binding relationship between genes. Fluorescence in situ hybridization assay was used to localize the expression of LINC01207 in NSCLC tissue. qRT-PCR and Western blot assays were used to measure the expression of LINC01207, miR-525-5p and ARHGAP11A. CCK-8 assay, Transwell assay and flow cytometry assay were used to detect NSCLC cell abilities. Mouse xenograft models further determined the effect of LINC01207 on the growth of NSCLC in vivo. RESULTS: LINC01207 was up-regulated in NSCLC tissue and cells, which was mainly localized in the cytoplasm. LINC01207 knockdown could inhibit the proliferation, migration and invasion of cancer cells and induce cell apoptosis. In addition, silencing LINC01207 could suppress tumor growth in vivo. LINC01207 could sponge and inhibit the expression of miR-525-5p in NSCLC cells, and inhibiting LINC01207 and miR-525-5p simultaneously could reverse the effect of miR-525-5p on the progression of NSCLC cells. Further study on downstream target genes showed that miR-525-5p could restrain the expression of ARHGAP11A, and then affect the progression of NSCLC. LINC01207 acting as a competing endogenous RNA (ceRNA) could regulate the expression of ARHGAP11A by competitively binding with miR-525-5p. CONCLUSION: LINC01207 regulates the progression of NSCLC by regulating the miR-525-5p/ARHGAP11A axis as a ceRNA and plays a carcinogenic role. In conclusion, our study elucidates the mechanism of LINC01207 regulating the progression of NSCLC, and provides a new idea for the diagnosis and treatment of NSCLC guided by lncRNA.
Clinical implication and prognostic significance of FLT3-ITD and ASXL1 mutations in Egyptian AML patients: A single-center study
Authors: Ebian Huda F. , Elshorbagy Sherin , Mohamed Haitham , Embaby Ahmad , Khamis Tarek , Sameh Reham , Sabbah Norhan A. , Hussein Samia
Published: August 2021

BACKGROUND: Both Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and Additional Sex Comb-like 1 (ASXL1) mutations are frequent and early genetic alteration events in acute myeloid leukemia (AML) patients. These genetic alterations may be associated with an unfavorable prognosis. OBJECTIVE: Up to our knowledge, this is the first study performed to evaluate the clinical implication and prognostic significance of FLT3-ITD and ASXL1 mutations and their coexistence on the outcome of Egyptian AML patients. METHODS: Our study included 83 patients with AML who were subjected to immunophenotyping and detection of FLT3-ITD and ASXL1 gene mutation by polymerase chain reaction (PCR) and real-time PCR, respectively. RESULTS: FLT3-ITD and ASXL1 mutations were detected in 20.5% and 18.1% of AML patients respectively. Seven patients (8.4%) had co-expression of both genes’ mutations. FLT3-ITD mutation was significantly higher in younger age, higher WBCs count and poor cytogenetic risk patients (P= 0.01, < 0.001 and 0.008 respectively). ASXL1 mutation was significantly higher in intermediate cytogenetic risk patients (P= 0.2). The mean period of survival and relapse-free survival (RFS) were significantly reduced in FLT3-ITD and ASXL1 mutations compared with their non-mutant types (P= 0.01 and 0.03 respectively). Both mutations were independent risk factors for overall survival (OS) and (RFS) in univariate and multivariate analysis in AML patients. CONCLUSION: FLT3-ITD and ASXL1 gene mutations or their coexistence can predict a poor prognosis in AML patients.
Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis
Authors: Foda Abd AlRahman Mohammad , Alamer Haitham Abdulkarem , Ikram Nadeem , Helali Hadi Abdulhadi , Fayad Fayza Sami , Hussian Sara Waleed , Abdelwahab Khaled , Akl Tamer , Emarah Ziad , Ramez Ahmed M.
Published: August 2021

BACKGROUND: CD10 and CD15 expression has been reported in several tumors. Whether CD10 and CD15 have a role in colorectal mucinous and signet ring adenocarcinoma (MSA) tumorigenesis is not yet known. OBJECTIVE: We aimed to investigate the role of CD10 and CD15 expression in mucinous colorectal adenoma-carcinoma sequence (ACS) and determine if there is any clinical and prognostic significance associated with their expression. METHODS: Seventy-five cases of colorectal MSA, and 9 cases of adenoma samples were collected. Manual TMA blocks were constructed and immunohistochemistry for CD10 and CD15 was done. RESULTS: Compared to adenomas, CD15 expression was significantly higher in MSA (p= 0.002), in contrast to CD10 expression. CD15 positivity was significantly associated with microsatellite stable (MSS) tumors (p= 0.018). The association between CD10 positivity and fungating tumor growth showed marginal significance. Unlike CD10, CD15 positivity showed significant association with overall survival of colorectal MSA patients. CONCLUSIONS: CD15 expression seems to have a role in mucinous colorectal ACS, with significant impact on the survival of MSA patients. Further studies are suggested to identify any genetic alterations that may underlie a potential association with disease progression.
Combining Low-Dose Radiation Therapy and Magnetic Resonance Guided Focused Ultrasound to Reduce Amyloid-β Deposition in Alzheimer’s Disease
Authors: Farace Paolo , Tamburin Stefano
Published: August 2021

Amyloid-β deposition is one of the neuropathological hallmarks of Alzheimer’s disease (AD), but pharmacological strategies toward its reduction are poorly effective. Preclinical studies indicate that low-dose radiation therapy (LD-RT) may reduce brain amyloid-β. Animal models and proof-of-concept preliminary data in humans have shown that magnetic resonance guided focused ultrasound (MRgFUS) can reversibly open the blood-brain-barrier and facilitate the delivery of targeted therapeutics to the hippocampus, to reduce amyloid-β and promote neurogenesis in AD. Ongoing clinical trials on AD are exploring whole-brain LD-RT, which may damage radio-sensitive structures, i.e., hippocampus and white matter, thus contributing to reduced neurogenesis and radiation-induced cognitive decline. However, selective irradiation of cortical amyloid-β plaques through advanced LD-RT techniques might spare the hippocampus and white matter. We propose combined use of advanced LD-RT and targeted drug delivery through MRgFUS for future clinical trials to reduce amyloid-β deposition in AD since its preclinical stages.
Characterization of a Knock-In Mouse Model with a Huntingtin Exon 1 Deletion
Authors: Braatz Elise M. , André Emily A. , Liu Jeh-Ping , Zeitlin Scott O.
Published: August 2021

Background:

The Huntingtin (HTT) N-terminal domains encoded by Huntingtin’ s ( HTT) exon 1 consist of an N17 domain, the polyglutamine (polyQ) stretch and a proline-rich region (PRR). These domains are conserved in mammals and have been hypothesized to modulate HTT’s functions in the developing and adult CNS, including DNA damage repair and autophagy.

Objective:

This study longitudinally characterizes the in vivo consequences of deleting the murine Htt N-terminal domains encoded by Htt exon 1.

Methods:

Knock-in mice with a deletion of Htt exon 1 sequences ( Htt ΔE1) were generated and bred into the C57BL/6J congenic genetic background. Their behavior, DNA damage response, basal autophagy, and glutamatergic synapse numbers were evaluated.

Results:

Progeny from Htt ΔE1/+ intercrosses are born at the expected Mendelian frequency but with a distorted male to female ratio in both the Htt ΔE1/ ΔE1 and Htt+/+ offspring. Htt ΔE1/ ΔE1 adults exhibit a modest deficit in accelerating rotarod performance, and an earlier increase in cortical and striatal DNA damage with elevated neuronal pan-nuclear 53bp1 levels compared to Htt+/+ mice. However, a normal response to induced DNA damage, normal levels of basal autophagy markers, and no significant differences in corticocortical, corticostriatal, thalamocortical, or thalamostriatal synapses numbers were observed compared to controls.

Conclusion:

Our results suggest that deletion of the Htt N-terminus encoded by the Htt exon 1 does not affect Htt’s critical role during embryogenesis, but instead, may have a modest effect on certain motor tasks, basal levels of DNA damage in the brain, and Htt function in the testis.
Hybrid spectrum management using integrated fuzzy and femtocells in cognitive domain
Authors: Revathy K. , Thenmozhi K. , Praveenkumar Padmapriya , Amirtharajanr Rengarajan
Published: August 2021

In Today’s pandemic situation, ‘Spectrum accessing and smart usage’ is the sacred Mantra uttered by every individual citizen in the world. Work from home for techies, online classes for students, games for kids, webinar for teaching fraternity etc., are going almost on indoor coverage without any limit in pace because of the smart spectrum coverage by the network service providers. This paper provides an add-on facility to the existing wireless infrastructure to provide a better user experience in this highly regrettable routine. In this paper, a cognitive domain unused spectrum holes are efficiently handled by (i) adaptive spectrum management technique; (ii) Fuzzy Inference System based spectrum administration and (iii) Hybrid Cognitive Femtocell approaches based on the user demand and their applications. The proposed integrated cognitive femtocell and Fuzzy-based approach reduces the indoor coverage problems and enhances the throughput of the macrocell users by allowing adaptive spectrum management based on the demand, thereby eliminating spectrum underlay and overlay problems during critical conditions. In cognitive femtocell networks, the access points are prepared and installed with Cognitive Radio which can determine spectrum dynamically by macrocells and nearby Femto Access Points. It adjusts its radiating parameters to evade the macrocells’ interferences and the neighbouring femtocells, thereby maximising the spectrum band’s overall utility.
The consistent vehicle routing problem under uncertain environment
Authors: Yang Meng , Ni Yaodong , Yang Xiangfeng , Ralescu Dan A.
Published: August 2021

In the increasingly competitive logistics industry, much more emphasis has been put on customer satisfaction by firms to distinguish themselves from their competitors. Motivated by the practices, the consistent vehicle routing problem (ConVRP) incorporates service consistency into the vehicle routing problem to improve customer satisfaction. However, the majority of the existing research considers the ConVRP in a deterministic environment while the uncertainties are not fully studied. Therefore, this paper solves the consistent vehicle routing problem under uncertain environment (UnConVRP) taking into account uncertain customer demands, travel times, and service times. Over a multi-day planning horizon, customers may have multi-day or single-day service requirements. The same driver is assigned to each customer almost at the same time each day when customers require service. The objective is to design the routes for vehicles over the planning horizon under uncertain environment while maintaining service consistency. Two uncertain programming models are established based on different decision criteria and the crisp equivalents are proposed using uncertainty theory. An efficient template-based solution framework is designed to solve the models where the artificial bee colony algorithm is embedded. Initially, the template route is constructed to guarantee the service consistency of frequent customers. Then the final daily routes can be derived from the template route. Finally, numerical experiments are performed to show the effectiveness of the proposed algorithm.
A novel approach for solving all-pairs shortest path problem in an interval-valued fuzzy network: Suggested modifications
Authors: Bhatia Tanveen Kaur , Kumar Amit , Appadoo S.S.
Published: August 2021

Enayattabr et al. (Journal of Intelligent and Fuzzy Systems 37 (2019) 6865– 6877) claimed that till now no one has proposed an approach to solve interval-valued trapezoidal fuzzy all-pairs shortest path problems (all-pairs shortest path problems in which distance between every two nodes is represented by an interval-valued trapezoidal fuzzy number). Also, to fill this gap, Enayattabr et al. proposed an approach to solve interval-valued trapezoidal fuzzy all-pairs shortest path problems. In this paper, an interval-valued trapezoidal fuzzy shortest path problem is considered to point out that Enayattabr et al.’s approach fails to find correct shortest distance between two fixed nodes. Hence, it is inappropriate to use Enayattabr et al.’s approach in its present from. Also, the required modifications are suggested to resolve this inappropriateness of Enayattabr et al.’s approach.
Broker-based optimization of SLA negotiations in cloud computing
Authors: Bharti Priyanka , Ranjan Rajeev , Prasad Bhanu
Published: August 2021

Cloud computing provisions and allocates resources, in advance or real-time, to dynamic applications planned for execution. This is a challenging task as the Cloud-Service-Providers (CSPs) may not have sufficient resources at all times to satisfy the resource requests of the Cloud-Service-Users (CSUs). Further, the CSPs and CSUs have conflicting interests and may have different utilities. Service-Level-Agreement (SLA) negotiations among CSPs and CSUs can address these limitations. User Agents (UAs) negotiate for resources on behalf of the CSUs and help reduce the overall costs for the CSUs and enhance the resource utilization for the CSPs. This research proposes a broker-based mediation framework to optimize the SLA negotiation strategies between UAs and CSPs in Cloud environment. The impact of the proposed framework on utility, negotiation time, and request satisfaction are evaluated. The empirical results show that these strategies favor cooperative negotiation and achieve significantly higher utilities, higher satisfaction, and faster negotiation speed for all the entities involved in the negotiation.
Energy and noise characteristics of a SEPIC buck-boost converter with unipolar and bipolar output
Authors: Babenko V. P. , Bityukov V. K.
Published: August 2021

Some advantages of the SEPIC buck-boost converter makes it stand out from other configurations. It makes possible to obtain from a unipolar input voltage both unipolar and bipolar output voltage with a good symmetry between positive and negative output voltages. It also provides efficient performance as well as circuit simplicity in unipolar and bipolar topology owing to the use of a single switch which can be operated by available integrated controllers of boost converters. The article considers the topologies of a SEPIC buck-boost converter built according to the traditional scheme (with two inductors) and according to the scheme on magnetically coupled chokes. To analyze the processes and factors affecting the converter operation efficiency, a circuit simulation has been done using the Electronics Workbench. The results of the investigation of a pulsed DC converter of input voltage to unipolar or bipolar output voltage using SEPIC buck-boost topology are presented. The circuit simulation enables to specify the switching process characteristics, to estimate the ripple level of the input current and its spectral characteristics, and to develop recommendations concerning the choice of parameters of converters elements and generation of control signals. Based on the simulation results, the load, control, and noise characteristics of the converter are obtained. The level of symmetry of positive and negative output voltage is investigated for the converter on discrete and magnetically coupled chokes. The assessment of the effect of leakage inductance on converters with magnetic coupling of inductive elements is given. Examples of practical implementation of converters built according to the SEPIC topology are shown. It is found that the resistance of the choke windings, which is less than 0.5 Ohm, has practically no effect on the efficiency of the converter, retaining the factor of about 0.9 in a wide range of load currents, while the main source of conversion losses is a passive diode switch. Synchronous converter circuits of a number of manufacturers are more efficient, but require more complex controllers for active switches with elements for protection against through currents.
ФОРМУВАННЯ КУЛЬТУРИ ВЕДЕННЯ ЗДОРОВОГО СПОСОБУ ЖИТТЯ МАЙБУТНІМИ ОФІЦЕРАМИ-ПРИКОРДОННИКАМИ
Authors: ГАЛІМОВ Анатолій , КОВАЛЬСЬКА Ірина
Published: August 2021

У статті проведений аналіз сучасного стану та визначені основні напрями формування культури ведення здорового способу життя під час освітнього процесу майбутніми офіцерами-прикордонниками. Проблема здорового способу життя в українському суспільстві з інституційного рівня перейшла на загальнодержавний і міждержавний, що свідчить про її виняткову актуальність і першочергову важливість. Результати аналізу напрямів наукових досліджень свідчать, що у контексті підготовки майбутніх фахівців до здорового способу життя вчені обґрунтовували теоретичні та методичні основи формування культури здоров’язбереження з позицій поглядів і переконань майбутнього фахівця, визначали професійно-прикладні основи формування здорового способу життя майбутніх фахівців і використовували педагогічні здоров’язбережувальні технології в системі підготовки майбутніх фахівців. У сучасних умовах прикордонної служби, які пов’язані з великим навантаженням на персонал, складними умовами служби, перенапруженням упродовж робочого дня, актуальними стають загальні складові здорового способу життя, що включають систематичні фізичні вправи, правильне харчування, відмову від куріння і наркотичних засобів, обмежене вживання алкоголю, здатність долати стреси, уміння розслаблятися, профілактичні обстеження, відсутність несприятливих для здоров’я звичок. Здійснення усіх цих складових можливе лише за умови певних кроків, які досягаються високим рівнем самосвідомості у вигляді мотивів, інтересів, ціннісних орієнтацій, що активно скеровують практичну діяльність на формування здорового способу життя.Оскільки проблема формування здорового способу життя як складової частини культури здоров’язбереження майбутніх фахівців-прикордонників стосується найрізноманітніших сфер життя, вважаємо, що підхід до її вирішення повинен бути інтегративним .Готовність до здорового способу життя формується під час освітнього процесу в НАДПСУ упродовж усього періоду навчання практично на усіх кафедрах. Водночас формування основних складових проходить на кафедрі психології, педагогіки та соціально-економічних дисциплін, кафедрі фізичного виховання. Зокрема, курсанти, які навчаються за першим (бакалаврським) рівнем вищої освіти за різними спеціальностями, основні знання та навички щодо формування здорового способу життя отримують за рахунок навчальних дисциплін: психологія здоров’я; психогігієна та психопрофілактика; педагогіка і психологія; професійна педагогіка та морально-психологічне забезпечення; фізичне виховання. Формування компетентностей майбутнього офіцера-прикордонника, який веде здоровий спосіб життя, відбувається як під час реалізації заходів по роботі з персоналом, так і в освітньому процесі навчального закладу. За результатами проведеного аналізу зроблено висновок, що формування здорового способу життя – складний процес, який потребує залучення якнайбільшої кількості відділів, служб та кафедр, і насамперед – самих майбутніх прикордонників.
PEDAGOGICAL CONDITIONS AND FEATURES OF FORMATION OF PROFESSIONAL COMPETENCE TO FUTURE SPECIALISTS IN PHYSICAL THERAPY, ERGOTHERAPY
Authors: КРУПА Валентина , ЛОБОДА Ірина
Published: August 2021

The article reveals the content of the defined in the study pedagogical conditions of training physical rehabilitation specialists in higher education institutions. The features and impact of these conditions on the quality of training of specialists as one of the main elements of the fundamental basic components of improving the educational process in an educational institution are briefly presented. Various aspects of training future specialists in physical rehabilitation are presented in the works of national and foreign scientists. The study of the issues of forming the professional competence to physical rehabilitation specialists is one of the topical areas of interdisciplinary research, both in our country and abroad. Methodological and theoretical aspects of the development of personal professional competence have been considered by scientists of different generations. The authors focus on the fact that the reform of higher education and Ukraine’s entry into the European educational and scientific space is due to increasing demands on the professionalism of graduates of higher education institutions in a competitive market environment. Orientation on the development of the student as a personality, individuality and active subject of professional activity can be realized only on the humanistic and democratic basis of pedagogical activity in higher education institutions.In the process under study, there is a whole set of contradictions that require a constructive solution. In order to eliminate these contradictions, there was conducted a study and worked out the pedagogical technology to improve the formation of professional competence to physical rehabilitation specialists. The authors made appropriate conclusions about the participation of the teaching staff for improving this process and the features of the psychological readiness of students for their future profession.
ОСОБЛИВОСТІ РЕАЛІЗАЦІЇ МІЖДИСЦИПЛІНАРНИХ ЗВ’ЯЗКІВ “МОРСЬКОЇ ПРАКТИКИ” Й “НАВЧАЛЬНОЇ ПЛАВАЛЬНОЇ ПРАКТИКИ” У ЗАКЛАДІ ВИЩОЇ ОСВІТИ МОРСЬКОГО ПРОФІЛЮ
Authors: РЯБУЩЕНКО Олег , КВАСНИКОВ Павло
Published: August 2021

У статті представлено вирішення наукового завдання щодо реалізації міждисциплінарних зв’язків навчальної дисципліни “Морська практика” й навчальної плавальної практики у закладі вищої освіти морського профілю з метою удосконалення професійної підготовки майбутніх фахівців спеціальності “Навігація і управління морськими суднами”. Мета статті полягає в обґрунтуванні можливості поліпшення якості практичної підготовки курсантів (майбутніх фахівців із навігації і управління морськими суднами) шляхом авторської реалізації міжпредметних зв’язків навчальної дисципліни “Морська практика” й навчальної плавальної практики у закладі вищої освіти морського профілю. Для цього проаналізовано низку нормативно-правових актів. З результатів аналізу стає очевидним, що важливим компонентом підготовки майбутніх фахівців із навігації і управління морськими суднами є практика. Проте її проходження передбачає опанування курсантами (студентами) теоретичних знань та практичних навичок. З’ясовано, що існує суперечність, яка полягає у невідповідності або обмежених дидактичних можливостях навчально-матеріальної (матеріально-технічної) бази професійної підготовки курсантів (студентів) у закладах вищої освіти морського профілю і швидким темпом оновлення техніки і засобів праці й управління ними на суднах. Також науковці вказують на протиріччя між вимогами роботодавців до професійної компетентності фахівців морського та річкового транспорту та недостатньою практичною підготовкою, обсяг якої визначається професійними нормативами в галузі професійної морської діяльності. Вирішення цих суперечностей можливе шляхом використання дидактичного потенціалу міждисциплінарних зв’язків навчальних дисциплін та плавальної практики. Запропоновано під час вивчення навчальної дисципліни “Морська практика” реалізувати методичні вказівки до практичних робіт, якими передбачено набуття курсантами (студентами) знань щодо застосування корабельного палубного обладнання; вивчення питань повсякденної організації судна; вивчення пристроїв і матеріалів під час виконання корабельних робіт, для забезпечення безпеки плавання і стоянки судна в різних умовах обстановки тощо. Ці та інші знання і компетентності необхідні під час проходження практичної підготовки, яка поділяється на навчальну плавальну практику (обов’язковий компонент освітньо-професійної програми) та виробничі плавальні практики за видами (є вибірковими компонентами освітньо-професійної програми).
ЗАСТОСУВАННЯ ІННОВАЦІЙНИХ ТЕХНОЛОГІЙ НАВЧАННЯ ПІД ЧАС ВИКЛАДАННЯ “МОРЕХІДНОЇ АСТРОНОМІЇ” МАЙБУТНІМ СУДНОВОДІЯМ
Authors: ЧЕРОЙ Людмила
Published: August 2021

У статті представлено вирішення наукового завдання щодо удосконалення професійної підготовки майбутніх судноводіїв у морських закладах вищої освіти шляхом застосування інноваційних технологій навчання. Мета статті полягає в узагальненні можливостей використання інноваційних технологій під час вивчення навчальної дисципліни “Морехідна астрономія” майбутніми судноводіями. Для цього проаналізовано низку наукових праць з теми дослідження за авторством вітчизняних та зарубіжних учених. Розкрито специфіку професійної підготовки зазначених фахівців. Проаналізовано зміст та особливості навчальної дисципліни “Морехідна астрономія”. Подано характеристику педагогічних інноваційних методів, зокрема задачного та кейс-методу. Автор описала сутність задачного методу, особливості застосування якого полягають у розробленні науково-педагогічними працівниками практичних завдань, що є своєрідними моделями майбутніх професійних ситуацій. З’ясовано, що цей метод є одним із найбільш доцільних у вивченні морехідної астрономії. Описано різновиди задач за видами та у яких навчальних питаннях варто використовувати. Щодо кейс-методу, то він полягає у розробленні завдань професійного спрямування у вигляді блоків або кейсів. Автор наголошує на розробленні реальних або придуманих ситуацій у професійній підготовці майбутніх судноводіїв. У статті рекомендується кейси для майбутніх судноводіїв розробляти так, щоб вони змогли запропоновані ситуації проаналізувати та знайти їхнє оптимальне вирішення. Важливою умовою розробки кейсів є не подання звичайного опису ситуації, а формулювання у ній певної суперечності. Сформульовано висновки проведеного дослідження та перспективи подальших наукових пошуків.
Présence d’Evania appendigaster (Linné, 1758) en Guadeloupe (Hymenoptera, Evaniidae)
Authors: Jourdan Toni
Published: August 2021

Presence of Evania appendigaster (Linnaeus, 1758) in Guadeloupe (Hymenoptera, Evaniidae). The ensign wasp Evania appendigaster (L.) was reported for the first time from Guadeloupe. This is the southernmost mention from West Indies. E. appendigaster could be implanted in Martinique where its presumed host Periplaneta spp. was introduced.