bluuebunny/crossref_metadata_2025 huggingface dataset:
APPLE TREES YIELDING AND FRUIT QUALITY DEPENDING ON THE CROP LOAD, BRANCH TYPE AND POSITION IN THE CROWN
Authors: Szot Iwona , Lipa Tomasz
Published: April 2019

The study was conducted from 2013 to 2015 on 10–13-year-old apple trees cv. ‘Szampion’ (M.9. rootstock) in experimental orchard of Department of Pomology, University of Life Sciences in Lublin. On the trees intensively flowering in 2013, the thinning treatments were performed as follows: thinning at the pink bud stage to the 50% of flower clusters leaving only a king flower in the remaining flower clusters; thinning at the pink bud stage to the 50% of flower clusters leaving only one lateral flower in the remaining flower clusters, thinning 4 weeks after full bloom to the 50% of fruit clusters leaving only a fruit from king flower in the remaining fruit clusters, thinning 4 weeks after full bloom to the 50% of fruit clusters leaving only one fruit from lateral flower in the remaining fruit clusters. Intensively flowering control trees in 2013 and poorly flowering trees in 2013 were left unthinned. The best results in terms of regularity of yielding and high-quality fruits after thinning at pink bud stage to king flower, were obtained. The largest fluctuations in yields were observed with the control tree that flowered poorly in the beginning of the study. It was found that the cultivar ‘Szampion’ is characterized by equal distribution of fruits in lower and middle parts of crown, however in the top of crown, the amount of fruits is significantly lower. Apples with the largest mean fruit weight were from spurs on wood older than two years. However the best flesh firmness, soluble solids and dry matter content was detected in fruits from brindles.
HARDENING PRETREATMENT BY DROUGHT AND LOW TEMPERATURE ENHANCED CHILLING STRESS TOLERANCE OF CUCUMBER SEEDLINGS
Authors: Ghanbari Fardin , Kordi Sajad
Published: April 2019

Chilling stress is of major limiting factors influencing the growth and development of warm-season crops like cucumber. In this research, the possibility of chilling tolerance of cucumber seedlings was investigated through employing the drought and low-temperature pretreatments. The factorial experiment consisted of two factors including cucumber cultivars (i.e. ‘Super Dominos’ and ‘Super Star’) and hardening treatments (control, low temperatures at 10°C, and 15°C and drought simulated by 10% and 20% PEG) based on completely randomized design (CRD) in 3 replications. After applying treatments and providing them 48 h opportunity to be recovered, the seedlings were subjected to 3°C for a six-day period and 6 h for each day. All hardening treatments improved seedlings’ growth, chlorophyll content, total phenol (TP) and antioxidant enzyme activities, while reducing chilling injury index and malondialdehyde (MDA) content. Comparing to temperature hardening, the drought pretreatment showed to have a better effect on inducing the chilling tolerance into cultivars. Overall, the results of this experiment showed that employing drought and low-temperature pretreatments enabled cucumber seedlings to mitigate the harmful effects of chilling.
SECRETORY STRUCTURES AND ESSENTIAL OIL COMPOSITION OF SELECTED INDUSTRIAL SPECIES OF LAMIACEAE
Authors: Kowalski Radosław , Kowalska Grażyna , Jankowska Monika , Nawrocka Agnieszka , Kałwa Klaudia , Pankiewicz Urszula , Włodarczyk-Stasiak Marzena
Published: April 2019

The objective of the study was to perform micromorphological analyses of the secretory structures of leaves and stems of oil-bearing industrial plants from the Lamiaceae family such as lemon balm (Melissa officinalis L.), peppermint (Mentha × piperita L.), sage (Salvia officinalis L.), marjoram (Origanum majorana L., syn. Origanum dubium Boiss.), rosemary (Rosmarinus officinalis L.) and common thyme (Thymus vulgaris L.) using light microscope and scanning electron microscope. In addition, an estimation of the content of volatile substances in the plant species under study was performed using GC-MS, as well as the qualitative and quantitative analysis of essential oil, that is an important component in terms of the estimation of raw material applicability for use in the industry. In the epidermal cells of studied plants, 2 types of Lamiaceae-type glandular trichomes were identified: short- and long-stalked capitate glandular trichomes with single- and bicellular secretory capitulum, and peltate glandular trichomes with eight- and over a dozen-cell secretory capitulum. Capitate trichomes were densely distributed on the surface of the epidermis, while peltate trichomes were sparse, though regular, and were situated in depressions. Glandular trichomes were found more frequently on leaves than on stems. The cuticle of the abaxial of leaf was characterized in most cases by the occurrence of larger average diameter peltate trichomes compared to the cuticle of the adaxial side of leaf. Peppermint produced the largest structures accumulating essential oil on the leaves (average diameter of peltate trichomes – 78.48 µm on the adaxial side of leaf, up to 96.43 µm), while on the stem, the highest average diameter of the peltate trichomes was observed in sage (an average of 75.53 µm, up to 85.99 µm). The lemon balm was characterized by the presence of capitate and peltate trichomes with the smallest diameter (an average of 44.26 µm). Lemon balm was characterized by the greatest density of glandular trichomes compared to other plant species. Among the plants studied, the highest content of oil was noted in the case of thyme and peppermint (2.22% and 2.20% v/w, respectively), and the lowest in green parts of lemon balm (0.17% v/w). The isolated essential oils contained predominantly components from the groups of monoterpenes and sesquiterpenes, and it is the presence of those substances that determines the possibility of utilizing the plants studied for a variety of purposes.
INFLUENCES OF PRE-SOWING TREATMENTS ON THE GERMINATION AND EMERGENCE OF DIFFERENT MULBERRY SPECIES SEEDS
Authors: Gündüz Kazim , Karaat Fırat Ege , Uzunoğlu Fulya , Mavi Kazım
Published: April 2019

Morus genus includes more than 20 species, some of which are commercially important mulberries with different fruit color and shape. Even though the trees of those species are propagated by rooting of cuttings in practice, mulberry seeds are of importance for breeding studies and rootstock seedling propagation. For that reason, this study was conducted to improve the seed performance of four mulberry species by different pre-sowing treatments including; 3% KNO3, GA3 at 500 ppm, organic priming with herbal tea brewed from marigold flowers petals and hydro priming. Results of the parameters of emergence characteristics and seedling vigor were evaluated. According to the results that varied between different species and pre-treatments, since emergence percentage and time, and seedling vigor were improved by the treatments, it was concluded that pre-sowing applications, especially GA3 and hydro priming, were beneficial in improving the seed performance of mulberry species included in the study.
Effects of orally administered raltegravir in cats with experimentally induced ocular and respiratory feline herpesvirus-1 infection
Authors: Spertus Chloe B. , Pennington Matthew R. , Van de Walle Gerlinde R. , Badanes Zachary I. , Judd Bonnie E. , Mohammed Hussni O. , Ledbetter Eric C.
Published: April 2019

OBJECTIVE

To determine the effects of orally administered raltegravir in cats with experimentally induced ocular and respiratory feline herpesvirus-1 (FHV-1) infection.

ANIMALS

14 healthy 6-month-old unvaccinated specific pathogen–free cats.

PROCEDURES

On day 0, all cats were experimentally inoculated by topical application of 0.1 mL of a solution containing 106 plaque-forming units of FHV-1 strain FH2CS to the inferior conjunctival fornix of each eye. Cats were randomly assigned to receive either raltegravir (80 mg; n = 7) or lactose (250 mg; vehicle; 7), PO, every 12 hours for 14 days beginning on day 1. Cats were assigned clinical ocular and respiratory disease scores every other day from days 0 to 30. Conjunctival swab specimens were collected for detection of FHV-1 by virus isolation and real-time PCR assay at 3-day intervals from days 0 to 30. Confocal microscopy was performed on days 0 and 10 to assess corneal epithelial leukocyte infiltration. The assessed variables and duration of FHV-1 shedding were compared between the 2 treatment groups.

RESULTS

Cats in both groups developed moderate to severe conjunctivitis and ulcerative keratitis characteristic of FHV-1 infection. Median duration of FHV-1 shedding was shorter and signs of ocular and respiratory disease were less severe for raltegravir-treated cats than for vehicle-treated cats. However, the mean conjunctival FHV-1 titer and corneal epithelial leukocyte count did not differ between the 2 groups.

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested orally administered raltegravir might be effective for alleviation of ocular and respiratory signs of FHV-1 infection in cats. (Am J Vet Res 2019;80:490–497)
Pharmacokinetics and competitive pharmacodynamics of ADP-induced platelet activation after oral administration of clopidogrel to horses
Authors: Norris Jeffrey W. , Watson Johanna L. , Tablin Fern , Kozikowski Tania A. , Knych Heather K.
Published: April 2019

OBJECTIVE

To determine pharmacokinetics and pharmacodynamics after oral administration of a single dose of clopidogrel to horses.

ANIMALS

6 healthy adult horses.

PROCEDURES

Blood samples were collected before and at various times up to 24 hours after oral administration of clopidogrel (2 mg/kg). Reactivity of platelets from each blood sample was determined by optical aggregometry and phosphorylation of vasodilator-stimulated phosphoprotein (VASP). Concentrations of clopidogrel and the clopidogrel active metabolite derivative (CAMD) were measured in each blood sample by use of liquid chromatography–tandem mass spectrometry, and pharmacokinetic parameters were determined with a noncompartmental model.

RESULTS

Compared with results for preadministration samples, platelet aggregation in response to 12.5μM ADP decreased significantly within 4 hours after clopidogrel administration for 5 of 6 horses. After 24 hours, platelet aggregation was identical to that measured before administration. Platelet aggregation in response to 25μM ADP was identical between samples obtained before and after administration. Phosphorylation of VASP in response to ADP (20μM) and prostaglandin E1 (3.3μM) was also unchanged by administration of clopidogrel. Time to maximum concentration of clopidogrel and CAMD was 0.54 and 0.71 hours, respectively, and calculated terminal-phase half-life of clopidogrel and CAMD was 1.81 and 0.97 hours, respectively.

CONCLUSIONS AND CLINICAL RELEVANCE

Clopidogrel or CAMD caused competitive inhibition of ADP-induced platelet aggregation during the first 24 hours after clopidogrel administration. Because CAMD was rapidly eliminated from horses, clopidogrel administration may be needed more frequently than in other species in which clopidogrel causes irreversible platelet inhibition. (Am J Vet Res 2019;80:505–512)
Acoustic emission-based welding quality control of marine technology
Authors: Karlov Sergey , Sulzhenko Victor , Yakovlev Aleksander
Published: April 2019

This paper discusses the potential of acoustic emission-based methods in technical condition assessment of marine technology, including methodology and results of marine pipeline checks during pneumatic tests and welding quality control of hull structures directly in the process of their manufacturing.
Analytical analysis of fatigue life and wear rate of jack-ups at various stages of their life cycle
Authors: Aleksandrov Anatoliy , Kryzhevich Gennadiy , Filatov Anton , Rybalko Trifon
Published: April 2019

This paper gives modal and structural calculations of jack-up rigs at operational and transportation stages, as well as more accurate structural calculations for jack-up supports, as well as effective stress ranges at hot points. Based on these results, the paper gives a simplified fatigue strength calculation for jack-up support, by means of Weibull bi-parametric distribution. It also compares fatigue damage accumulation rates of jack-up at different stages of their life cycles, as well as predicts its residual lifetime.
Numerical simulation of shell under local loading
Authors: Taubin Aleksander , Rumyantsev Konstantin
Published: April 2019

This paper describes numerical model of the shell used in the simulation and determines its stress-strain parameters during the numerical experiment. The results of this simulation show a good correlation with the results of physical model tests.
HOW CAN PSYCHOLOGY AND RELIGIOUS BELIEFS AFFECT ON FRAUD TRIANGLE?
Authors: Ismail Bassem , Hamidah Hamidah
Published: April 2019

In this paper, I explore the emphasis of the fraud triangle as a salutary model for practitioner to extract fraud. This paper is anchored through psychology and religious theories, and is propped with prove from holy books. The findings point out that the Own lust “Hawa Nafsu” (HN) supporter and basic stone to control devil desire (DD) that control by humans lust that’s present new model in preventing fraud. Fraud is a manifold phenomenon, whose religious theories may not fit all the cases into fixed model. Thus, fraud tringle not adequately credible model, so antifraud practitioner should consider fraud from religious perspective. The study uses secondary sources of information get it from magazine articles, textbooks and the Internet. The discussion of the two theories contributes to understand frauds especially by legitimate accountants, auditors, fraudsters and other fraudulent entities. The study also serves as a guide to further research on fraud.
Analisis Penggunaan Sensor Kamera 3 Dimensi Kinect sebagai Media Pembelajaran Perkuliahan berbasis Student Centered Learning
Authors: Husodo Ario Yudo , Bimantoro Fitri , Arimbawa I Wayan Agus , Afwani Royana
Published: April 2019

Saat ini, kegiatan belajar mengajar di berbagai universitas di Indonesia umumnya dilakukan menggunakan laptop yang terhubung ke sebuah proyektor. Di dalam proses pengajaran, dosen cenderung menggunakan laptop di ruang kelas, menghubungkan tampilan layar laptop ke sebuah proyektor, kemudian menggunakan wireless pointer sebagai pengendali slide presentasi. Pendekatan semacam ini sayangnya tergolong kurang efektif di dalam perkuliahan berbasis Student Centered Learning (SCL). Di dalam SCL, mahasiswa merupakan pusat kegiatan perkuliahan, dimana keterlibatan dan interaksi mahasiswa di dalam proses penyampaian materi merupakan hal terpenting guna meningkatkan animo dan pemahaman mahasiswa mempelajari suatu topik. Penggunaan teknologi perkuliahan konvensional seperti laptop dan wireless pointer cenderung membuat perkuliahan menjadi 1 arah karena interaksi mahasiswa kurang dapat tersalurkan. Di dalam penelitian ini, dilakukan analisis dampak penggunaan teknologi informasi sensor kamera 3 dimensi Kinect sebagai media pembelajaran dalam suatu sistem Smart Classroom. Kinect merupakan sensor yang dapat menangkap gerakan tangan seseorang kemudian menginterpretasikan gerakan tersebut sebagai suatu perintah komputasi berdasarkan algoritma pemrograman tertentu. Berdasarkan hasil penelitian, penggunaan Kinect terbukti dapat meningkatkan efektivitas pembelajaran SCL dan antusiasme belajar mahasiswa karena mahasiswa dapat berinteraksi di dalam suatu materi perkuliahan secara lebih alami menggunakan gerakan tangan.
Effect of metformin gel against imiquimod–induced psoriasis in mice
Authors: Haider F. Alsaedi  , Haider Falih Shamikh Al-Saedi  , Adeeb Ahmed Kadhim  Al-Zubaidy  , Mukhallad Abdul Kareem Ramadhan  , Hussein Abdelamir Mohammad
Published: April 2019

Imiquimod-induced psoriasis is an animal model of psoriasis.  The antidiabetic metformin had anti-inflammatory, immunomodulation, antiangiogenesis and antiproliferative effect. The objective of this study was to evaluate the possible beneficial effect of metformin gel against imiquimod-induced psoriasis-like form by scoring the erythema and scaling besides measuring of tissue homogenate levels of IL17/IL23. Swiss albino mice were used in this experiment imiquimod 5% cream applied on shaved back of mice for six days, and this is an induction group and compared with a negative control group that involved mice treated with ointment base only for six days. Third group; metformin 10% gel applied on the back of mice with imiquimod for six days. The fourth group included used of metformin 15% gel with imiquimod for six days. This data was analysed for significant level when p ≥ 0.05 by using either ANOVA test for biochemical parameters levels evaluation.    Furthermore, imiquimod 5% cream of induction group caused an elevation of inflammatory parameters; IL17 and IL23 in skin tissue homogenate when being compared to   IL17   and IL23 level of the control group. Whereas, metformin 10% gels showed levels of IL17 and IL23 with significant different from induction group. In addition, metformin 15% gels exerted a significantly low level of IL17 and IL23. The possible considerable antipsoriatic activity of topical metformin gel through reducing scaling and erythema and mediated through modest anti-inflammatory effects by suppressing levels of IL17/23.
Is Nitric oxide the missing link in glucose homeostasis? A study on correlation of Nitric oxide and Insulin Resistance in Obstructive Sleep Apnoea
Authors: Ramya K  , Gowri Sethu  , Dhanasekar T
Published: April 2019

Nitric oxide is associated with glucose homeostasis. An independent relationship between Nitric oxide and insulin resistance in Prediabetic and Obstructive sleep apnea patients without pre-existing diabetes mellitus are equivocally linked to increased risk of type II diabetes. A reciprocal relationship seems to exist between nitric oxide and insulin resistance. Aim of this present study is to determine relationship between nitric oxide and glucose parameters in control, prediabetic and Obstructive sleep apnea. A cross sectional study was performed in 150. They were divided into, group I (control), group II (prediabetics) and group III (OSA). Fasting blood sugar (FBS), fasting insulin, HbA1c and nitric oxide were measured in these subjects and insulin resistance calculated by HOMA-IR. Data was analyzed statistically using Pearson’s correlation coefficient analysis, the significant value being P<0.05. Negative correlation was observed between the NO and insulin resistance in prediabetic (r=-0.627, P =<0.001) and OSA (r= -0.416, P=0.003) respectively. Nitric oxide is significantly inversely associated with insulin resistance in Prediabetic and Obstructive sleep apnea.
Anti-glycation study of hydro-alcohol and aqueous extracts of Moroccan plant species
Authors: Ramdan B  , Ramdan R  , El Karbane M  , El Maadoudi M  , Ben Mrid R  , Nhiri M
Published: April 2019

Inhibition of advanced glycation end products (AGEs) and free radicals generated during diabetes represents a major therapeutic target in the prevention and treatment of diabetic complications. Natural molecules present in fruits, vegetables and herbs and which are usually safe for human consumption, could represent a strong glycation inhibitor. Anti-glycation effect of nine plant species used in traditional medicine has been evaluated after extraction by hot (EAC) or cold (EAF) maceration and by ethanol (EE). Anti-glycation activity performed on a model system of bovine serum albumin, and methylglyoxal was measured by fluorescence and native electrophoresis. Total phenolic and flavonoid contents were assessed as well. Except for Sesamum indicum, all the species studied have an Anti-glycation effect. The highest effect was recorded in Laurus nobilis and was dose-dependent, inhibiting both formations of Amadori products and fluorescent AGEs. HPLC analysis revealed a richness of Laurus nobilis EE in phenolic compounds such as quercetin, vanillin and gallic acid. A strong correlation was registered between antioxidant power and phenolic/flavonoid content. In contrast, there was no correlation between antioxidant and anti-glycation power. Phenolic and flavonoid compounds were strongly involved in the observed anti-glycation effect. However, the anti-glycation activity obtained is probably attributed to non-antioxidant compounds.
Preparation of yeast mediated semiconductor nanoparticles by Candida albicans and its bactericidal potential against Salmonella typhi and Staphylococcus aureus
Authors: Venkat Kumar S  , Sowmya B  , Geetha R  , Karpagambigai S  , Jacquline Rosy P  , Rajeshkumar S  , Lakshmi T
Published: April 2019

Biosynthesis of nanoparticles using microorganism is widely used in biological applications due to its eco-friendly nature and lower cost. The present study aimed to investigate the yeast, Candida albicans for the synthesis of nano cadmium sulfide is a semiconductor nanoparticle. The yeast synthesized nanoparticles tested for its spectroscopic and microscopic characters. The peak at 420 nm identified by UV-Vis spectrophotometer confirms the Cadmium sulfide (CdS) nanoparticles synthesis preliminarily. Further, the nanoparticles were characterized using X-ray diffraction assay, scanning electron microscope, and elemental dispersive analysis. Finally, the synthesized Cadmium sulfide (CdS) nanoparticles were tested for its antibacterial activity against disease-causing pathogens such as Salmonella typhi and Staphylococcus aureus. The maximum zone of inhibition shows 15mm at the concentration of 100µl of CdS nanoparticle. Thus a promising antibacterial activity of yeast mediated synthesized Cadmium sulfide (CdS) nanoparticles was described.
Computational design, Synthesis of 4,6-dihydroxy-2-phenyl-1-benzofuran-3(2H)-one derivatives as new leads for anti-cancer activity
Authors: Raghava Doonaboyina  , Abhilasha Mittal  , Sridhar Babu Gummadi
Published: April 2019

Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Computation chemistry plays a major role in the development of new lead molecules. Computational tools docking, virtual screening, ADMET prediction are utilised in the identification of new lead molecules. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Benzofuranone was synthesized by reacting benzene diols, and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclised with sodium acetate. The compounds identity and purity were confirmed by spectral and analytical methods. Benzofuranone derivatives are screened antineoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds IA, IB, ID, IE, IF, was found to be with potent activity.
Detection of BCR-ABL gene in Chronic Myeloid Leukemia patients treated with Tyrosine Kinase Inhibitors Drugs by Gene Expert System
Authors: Maysaa Ali Abdul Khaleq  , Hussein Ali Saheb  , Ahmed M Sultan  , Mohsen A. N. Alrodhan
Published: April 2019

Chronic myeloid leukaemia (CML) is one of the human fatalities caused by genetic mutation and chromosomal translocation, a BCR-ABL fusion gene and as a result, Philadelphia chromosome is formed. The irregular tyrosine kinase activity of the encoded protein by this gene causes the establishment of the disease. This study was conducted at the period from September 2016 to February 2017,100 Iraqi CML patients were divided into two groups, first group of 50 patients were received Imatinib 400-800 mg/day, second group of another 50 patients were received 800 mg/day Nilotinib, WBC were microscopically counted using improved Neubauer ruled hemocytometer counting chamber. The results of WBC count in different disease duration and stages of treatment in the group of patients treated with Imatinib showed that highest WBC count was observed in newly diagnosed patients while there was a significant reduction in the WBC count after one month, after one year and final dose of treatment were 11.8, 6.4 and 8.1 respectively, on the other hand the results of WBC count  in the group of patients treated with Nilotinib showed that the highest WBC count was observed in newly diagnosed patients 87.54± 8.71 whereas the WBC count after one month, one year and at the final dose of treatment were 7.3, 6.8, 7.9 respectively with significant reduction in the WBC count. The results of the CML patient’s distribution according to BCR-ABL gene analysis in the patient's group treated with Imatinib showed that high concentration in newly diagnosed patients 4.753 as compared with significant reduction with other stages of treatment after one month and after one year 0.94 and 0.09 respectively.
A futuristic perspective in subsiding the symptoms of Parkinson’s Disease
Authors: Sreeja C Nair  , Sujaid Thayyilakandy  , Arjun KK  , Gayathri Krishnakumar  , Gayathri PS
Published: April 2019

Parkinson's disease (PD) is a neurodegenerative disorder that primarily impinges the dopaminergic neurons in a particular region of Brain termed as Substantia Nigra. The disease affects more than 1900 people per 100,000 aged 80 years and above. Furthermore, men are 1.5 times more prone than their counterpart. Potential biomarkers escalated the precise diagnosis and helped to initiate treatment to limit its adversity. The current therapeutic schemes are focused on administration of Dopamine precursor, Dopamine agonist, Monoamine oxidase (MAO) inhibitor, Catechol-o-methyl transferase (COMT) inhibitors and deep brain stimulation. The CNS delivery focuses mainly on increasing the dopamine level in the brain. CNS drug delivery faces a crucial challenge of crossing Blood Brain Barrier. Blood-Brain Barrier Penetration can be attained by several techniques. Conventional drug therapy yields harmful affects to the patients without much therapeutics. It is visible that crossing BBB is quite strenuous process. It is mandatory for developing a novel approach untangling these situations. Nanotechnology-based formulations like nanosuspensions, nanotubes etc. promotes the penetration of drug across the sophisticated barrier without creating any deterioration to cells or organs. Several novel routes for drug administration reduce dose intake with increased and precise pharmacological action. Nanoformulations and Novel routes of drug administration are a promising tool to enhance the action of drug which helps to abate the symptoms of the Disease and assist in the betterment in treatment.
Cultivation of oyster mushroom (Pleurotus sp) using different substrates and evaluate their potentials of antibacterial and phytochemicals
Authors: Sangeetha K  , Senthilkumar G  , Panneerselvam A  , Sathammaipriya N
Published: April 2019

Mushroom is a variety of gilled fungi belongs to the class Basidiomycetes. It grows on tropical and northern temperate regions mainly in a moist condition. Mushroom act as a reservoir of nutrients. Edible mushroom plays a vital role in maintaining human health. The most commonly used edible mushroom is Pleurotus (oyster). It is rich in Protein, fibre, minerals and vitamins. It has a variety of fascinating properties like anti-inflammatory, anticancer, antiaging, analgesic and immune modulator property. The present study investigates the various phytochemicals and antibacterial potentials from the methanol, ethanol and aqueous extracts of fruit body mushroom. The cultivation of mushroom using different substrates such as paddy straw and corn straw. The mushroom extracts were subjected to qualitative phytochemical screening using standard methods. The crude extracts contain Alkaloids, Steroids, Flavonoids, Saponins, Phenols, Tannins, Proteins, Amino acids, Carbohydrates, Reducing sugar. The results indicated that the ethanolic extract had shown significant antibacterial activity against the test organisms. Enterococcal infection is a common infection prevailing nowadays. This study suggests that mushroom possess antibacterial potential against enterococcal species. So, intake of mushroom acts as a medicine for enterococcal infections.
The anti-carcinogenic activity of Hydrastis Canadensis on oral cancer cell lines
Authors: Geetha RV  , Monica Antony  , Lakshmi Thangavelu
Published: April 2019

Naturals herbs are a topic commonly used for the research of drugs that could be used to treat cancer as it has become a leading cause of death in several developing countries. There is a constant demand for new therapies to treat and prevent this life-threatening disease. Scientific and research interest is drawing its attention towards naturally-derived compounds as they are considered to have less toxic side effects compared to current treatments such as chemotherapy. Goldenseal, commonly known as yellow puccoon has wide therapeutic activity. The bioactive components present are helpful in treating several problems in the human systems. They are capable of eliminating toxic substances due to the anti-cancer, anti-inflammatory and other properties. The study aims to do a study on the anti-carcinogenic activity of Hydrastis Canadensis on oral cancer cell lines. Through there researches it would be made available to all the people for an affordable cost. The sensitivity of KB (Oral squamous cell carcinoma) cells was determined individually by the MTT colourimetric assay. Higher concentrations of the herb induce increased cell inhibition, and it can give close and similar actions with tamoxifen. Studies indicate that goldenseal is biologically a very active plant which makes it very attention-able one.
Chrysin protects mice liver and kidney from methandienone-induced oxi-dative ‎stress, inflammation a multi-biomarker approach
Authors: Marwah Y. Falih  , Abbas A. Mohammed  , Ghassan M. Sulaiman
Published: April 2019

Methandienone is a medication that has wide uses by competitors and young people in ‎gyms ‎for fitness. Chrysin (CR) is a characteristic natural flavonoid that has to incorporate ‎being a ‎cancer prevention agent, anti-inflammatory and anti-oxidant agent. Mus Musculus ‎mice ‎were therefore used in the current work to test the effects of methandienone on ‎vital ‎physiological functions as expressed by the liver, renal function tests and oxidation ‎activity. ‎The reverse effects of chrysin were also tested for the treatment of methandienone in ‎order ‎to determine the possibility of lowering levels of side effects. The results showed ‎clear ‎changes in biochemical effects on liver and kidney functions as a result of treatment ‎with ‎methandienone were also evident; The treated mice showed a significant elevation in ‎the ‎concentrations of serum levels of the hepatic function enzymes (ALP, AST, ALT) ‎and ‎kidney functions parameters (urea and creatinine).‎‏ ‏Combined treatment of mice ‎with ‎‎(methandienone + 25 mg/kg chrysin) caused a significant reduction in urea level ‎and ‎activities of ALP, ALT and AST (p<0.05) as compared to treatment with ‎methandienone ‎alone. Treatment with (methandienone + 50 mg/kg chrysin) also resulted in ‎a significant ‎decrease in the renal level and ALP and AST activities as compared to methandienone- ‎treated ‎mice. The present study concludes that methandienone causes damages to the liver ‎and the ‎kidney, as indicated by elevated levels of their functional enzymes. This effect ‎indicates ‎it increases oxidative stress in these organs, possibly due to elevated production of ‎free ‎radicals.
Absorption enhancement effect of piperine and chitosan on ganciclovir sol-id lipid nanoparticles: formulation, optimization and invivo pharmacoki-netics
Authors: Ravindra Babu M  , Ravi Prakash P  , Devanna N
Published: April 2019

The purpose of the present study was to formulate Solid Lipid Nanoparticles (SLNs) of Ganciclovir (GCV) in combination with Chitosan and Piperine for absorption enhancement effect. GCV loaded SLNs were prepared by hot homogenization method, optimized and characterized. Formulated SLNs were incorporated with absorption enhancers and characterized for invitro absorption (with chicken intestine), histopathological and invivo pharmacokinetic studies. Invitro absorption studies revealed that the permeability coefficient of the prepared formulation is more when compared to the pure drug, so the permeability is more for prepared formulation. In vivo pharmacokinetic study showed a significant increase in the Cmax, AUC, biological half-life and decrease in elimination rate constant for prepared formulation compared to pure drug. Histopathological studies also showed mild reversible damage of epithelial cells with Chitosan which indicates the safety and efficacy of the formulation. Thus, GCV loaded SLNs prepared with Chitosan can be clinically promising for enhancing the oral, intestinal absorption of the said BCS Class-III drug.
An experimental study to assess the effectiveness of fresh amla juice with elemental iron versus elemental iron supplementation on anemia among adolescent girls in selected school at Chennai
Authors: Devi JK  , Jainvanitha  , Fabiola Dharaj  , Vasantha S
Published: April 2019

The present study was undertaken to assess the effectiveness of fresh amla juice with elemental iron versus elemental iron supplementation on anaemia among adolescent girls in selected school at Chennai. A total of 50 adolescent girls within the age group of 13-16years.with mild to moderate anaemia from selected schools in Chennai were part of the study after obtaining the written informed consent and assent as per guidelines. After recruiting, the participants were randomly grouped into two groups. Group 1: (n=25) 20ml fresh amla juice was given before lunch daily for 30 days and elemental iron  100 mg per week. Group 2: (n=25) 100mg of elemental iron per week for 30 days. Result – after intervention in the experimental group I the mean haemoglobin level increased (1.03gm/dl) than in control group II. The present study provides further evidence for the beneficial effects of amla juice in the management of anaemia. It concluded that fresh amla juice helps in iron absorption thereby increasing the HB level in experimental group I. We recommend further detailed studies in this area to recommend amla juice as a nutritive supplement for the management of anaemia.
The effectiveness of vestibular stimulation by rocking and vestibular exer-cises on postural stability, depression, anxiety and stress in elderly
Authors: Sahaya Rani  , Archana R  , Shyla Kamala Kumari
Published: April 2019

Using swings and rocking chair is a universal practice. Rocking was soothing as it offers relaxation through vestibular stimulation. Stimulation of vestibular receptors will begin during fetal life, and it was recommended to continue throughout life. The present study was undertaken to observe the effectiveness of vestibular stimulation by rocking on postural stability in the elderly. A total of 150 elderly male and females were part of the study after obtaining the written informed consent. After recruiting the participants, they were randomly grouped into three groups with 50 participants in each group. Neither exercise nor rocking was administered to the control group. Rocking was administered using a rocking chair once a day for 5 days in a week for 6 months for a rocking group. Rocking was administered using a rocking chair once a day for 5 days in a week + vestibular exercises were practiced two sessions per week for 6 months for rocking and vestibular exercise group. Demographic data were not significant between the groups. There was a significant decrease (P<0.001) in the stress score in both rocking the only group and rocking along with vestibular exercise group. The present study highlights the beneficial role of vestibular stimulation by rocking and by vestibular exercises in improving the postural stability and reducing the negative emotions like depression, anxiety and stress. Hence, the study recommends practicing vestibular stimulation either by rocking or by exercises in day to day life for better quality of life in general.
Correlation of nerve growth factor with antioxidants and sperm parameters among Iraqi infertile males
Authors: Shaymaa Jawad Abdulrahman  , Ibtisam A. AL-Ali  , Thikra Abd Aun Hassan  , Ammar Mohammed Qassim
Published: April 2019

The level of nerve growth factor (NGF) in the blood and seminal plasma of asthenozoospermia and oligoasthenozoospermia patients were compared to normozoospermic males and the relationship between NGF with sperm parameters and seminal antioxidant capacity were estimated to determine the role of NGF in the etiology of male infertility. Eighty-one infertile males and 40 normospermic control subjects were included in this stud. NGF levels were measured in the blood and seminal plasma, and its correlation with total antioxidant capacity (TAC), catalase (CAT) and glutathione (GSH) levels and sperm parameters were studied. There was a general trend of decreased in serum and seminal NGF concentrations of asthenozoospermic and oligoasthenozoospermic when compared to the normozoospermic samples. There was no significant association between NGF and seminal antioxidant status in asthenozoospermia and oligoasthenozoospermia males. Nevertheless, CAT positively correlated with sperm concentration, total sperm motility, and normal sperm morphology but only showed a statistically significant correlation to total sperm motility in asthenozoospermic males. A strong positive association was detected between seminal plasma TAC activity and total sperm motility in both asthenozoospermic and oligoasthenozoospermia males. A decrease NGF levels in serum and seminal plasma could have a significant role in the etiology of impaired sperm functions.
A sociedade de risco e a noção de cidadania: desafios para a educação científica e tecnológica
Authors: Pietrocola Maurício , Souza Carolina Rodrigues de
Published: April 2019

Ulrich Beck, em uma obra de 1986 intitulada "sociedade de risco", afirma que a vida social moderna se defronta com novas formas de perigo produzidas por ela mesma e que desafiam a humanidade. Isso implica que viver em uma "sociedade de risco" seria assumir uma atitude calculista em relação às possibilidades de ação, positivas e negativas, com que somos continuamente confrontados. Esse confronto impacta tanto a existência em nível individual, quanto em nível global. Neste trabalho pretende-se abordar de que forma essa avaliação da modernidade social impacta a noção de cidadania e coloca em suspensão as perspectivas contidas nas abordagens CTS e Alfabetização Científica e avança-se a discussão sobre os desafios da educação científica moderna reflexiva.
Por uma educação científica que problematize a mídia
Authors: Cardoso Danilo , Gurgel Ivã
Published: April 2019

O objetivo do trabalho é defender que umas das finalidades mais importantes para o ensino de ciências é a de problematizar a mídia. Para isso, primeiramente é feita uma discussão teórica sobre a epistemologia e  a educação freireana. Nela, dá-se destaque ao papel da problematização no processo de conscientização. Em seguida, é realizada uma discussão sobre o papel da mídia na sociedade, ressaltando-se seus usos políticos. A partir desta discussão faz-se uma revisão de artigos sobre Educação e Mídia e Mídias e Ensino de Ciências com o objetivo de destacar as principais potencialidades desta aproximação. Por fim, argumenta-se que somente uma educação científica que problematize a mídia permite uma formação cidadã e crítica.
Eixos de convergência da alfabetização científica e técnica no ensino médio integrado
Authors: Rodrigues-Moura Sebastião , Brito Licurgo Peixoto de
Published: April 2019

Com o finalidade de analisar e discutir os indicadores atuais da etapa final da educação básica no Brasil frente às propostas de sua reformulação, elencamos e analisamos eixos de convergência para à promoção da Alfabetização Científica e Técnica no ensino médio integrado a estudantes que almejam uma formação mais consolidada com o papel cidadão, aborde temas socialmente relevantes, vislumbre decisões a serem tomadas frente a situações-problemas do cotidiano, bem como destaque seu papel de protagonista na sociedade. Para tanto, ocupamo-nos em abordar reflexões iniciais sobre indicadores de desempenho dos estudantes e o atual panorama do ensino médio no Brasil, destacando ao longo do texto a proposição de um curso integrado, defendida por pesquisadores da educação brasileira. Com enfoque metodológico qualitativo, com caráter exploratória, do tipo documental, analisamos à luz da Análise Textual Discursiva (ATD) documentos oficiais de cursos técnicos integrados ao ensino médio de uma instituição federal de ensino no contexto amazônico-paraense, na busca de elementos de aproximação em educação, ciência e sociedade com vistas à ACT. Dessa análise emergiram quatro eixos de convergência, identificados como a (i) Prioridade a uma formação humanística e reflexiva, (ii) Elementos de interdisciplinaridade e contextualização, (iii) Formação para a cidadania, e (iv) Investigação social para a tomada decisões conscientes. Desses eixos, observamos, notadamente, que os resultados obtidos apresentam uma aproximação para a discussão, debate e fomento à educação, à ciência e a elementos de questões sociais para a formação regional.
Alfabetização científica e a construção de concepções na contexto de formação de professores
Authors: Sessa Patrícia Da Silva , Paiva Júlio Carvalho de , Casasco Emile Ferreira da Cunha , Silva João Rodrigo Santos da
Published: April 2019

O presente artigo investiga as concepções sobre Alfabetização Científica (AC) de professores de Ciências de 6º ao 9º ano da rede pública de um município do interior paulista em um contexto de formação continuada. Os dados foram coletados através de um questionário com perguntas abertas sobre a atividade da formação, as concepções dos professores antes e depois dessas atividades. Como resultados, alguns professores apresentaram mudanças de suas concepções sobre Alfabetização Científica no que diz respeito à necessidade de métodos científicos, nos permitindo apontar a necessidade de continuidade de pesquisas que contemplem esse tipo de abordagem bem como as formações continuadas de professores
Matemática e a inclusão do outro
Authors: Peralta Deise Aparecida , Gonçalves Harryson Júnio Lessa
Published: April 2019

Este texto se firma na necessidade de discutir a matemática escolar, como prática social, por um viés inclusivo em oposição a um caráter técnico e segregacionista que, por vezes, parece se apresentar nas salas de aula. Perseguindo os pressupostos habermasianos da Teoria da Inclusão do Outro, propomos uma reflexão desse tema, inicialmente, com um item introdutório sobre o caráter excludente do ensino de matemática escolar, apresentando, a seguir, a matemática entendida como prática social; o pensamento habermasiano, finalizando com a possibilidade de pensar o ensino de matemática como Inclusão do Outro.
A CRISE NA EDUCAÇÃO DE HANNAH ARENDT E A CRÍTICA ÀS CONCEPÇÕES EDUCACIONAIS DO PRAGMATISMO
Authors: Andrade Flávio Rovani de
Published: April 2019

Este artigo procura expor a crítica da filósofa Hannah Arendt (1906-1975) às concepções educacionais do Pragmatismo, em especial ao pragmatismo de John Dewey (1859-1952). Primeiramente, é exposta brevemente a teoria educacional de Hannah Arendt com base no texto A crise na educação, seu único texto eminentemente educacional. Por se articular com o todo de sua obra, faz-se também incursões na vasta obra da autora, a fim de ampliar a compreensão do sentido da educação no conjunto da filosofia e da teoria política arendtiana. Posteriormente, é tratada a crítica objeto deste artigo, propriamente dita, com base numa análise do texto Democracia e Educação, de Dewey, à luz da teoria arendtiana
Filosofía, educación e infancia
Authors: Duhart Olga Grau
Published: April 2019

El texto propone una perspectiva de articulación de la filosofía, la educación y la infancia en una suerte de trama de potencias que pueden concurrir fructíferamente en una propuesta que legitime y visibilice a niñas y niños como sujetos pensantes y productores de cultura. Se hace referencia al programa de Filosofía para Niños del filósofo Matthew Lipman y al valor de su proyecto educativo, como también al aporte de otros filósofos, especialmente el de Walter Kohan, que nos permiten pensar la relación entre filosofía, educación e infancia con mayor complejidad. Finalmente, se reflexiona sobre la significación de las preposiciones en las expresiones de filosofía con o para niños y niñas.
Entre la libertad de ser y hacer:
Authors: Márquez-Fernández Álvaro B.
Published: April 2019

La Filosofía para Niños y Niñas de M. Lipman, promueve una praxis de la vida que considera la libertad como el auténtico proyecto de realización individual y social, que debe ser asumido desde la infancia. Propiciar una experiencia investigativa y dialógica que le permita a los niños y las niñas problematizar filosóficamente la realidad, es decir, indagar acerca del sentido de cualquier acción, acto, praxis tiene su punto de origen en un interrogar-se por la libertad como experiencia que hace posible el desarrollo de la sensibilidad y la racionalidad. La conciencia de ser y estar libres, depende de la autonomía de una voluntad para decidir y del deseo para elegir el sentido que debe orientar la vida en su presente y proyección futura. Niños y niñas estimulados con experiencias de este tipo, podrán llegar a ser ciudadanos y ciudadanas capaces de lograr la transformación de la sociedad desde una justicia, bien, equidad y paz, compartida por todos.
Simón Rodríguez, la bildung de un extraño
Authors: Valera-Villegas Gregorio
Published: April 2019

Este trabajo es un ejercicio de aproximación a la bildung de un personaje, Simón Rodríguez. La bildung de un extaño según nuestra mirada. Un ejercicio otro, distinto, al menos, sobre un venezolano, latinoamericano por antonomasia, un pensador cosmopolita; del cual se ha dicho que fue el filósofo (el Sócrates de Caracas y/o de América), un político, un educador. En él realizamos una suerte de hermenéutica del texto escrito, narrado, y de la acción contada por testigos oculares. La carta, la biografía, el ensayo filosófico y pedagógico no sirvieron de pretextos para presentar a un Rodríguez, además del estraño, escritor. Finalmente, puede decirse, que se intenta contribuir, en alguna medida, con el estudio de la vida, del pensamiento y de la obra del así llamado, Don Simón Rodríguez.
Filosofia no Ensino Médio.
Authors: Tomazetti Elisete Medianeira , Marçal Katiuska I. , Ribeiro Tatiana De Melo
Published: April 2019

Neste espaço relataremos o desenvolvimento do projeto de pesquisa Filosofia, Cultura Juvenil e Ensino Médio desenvolvido no período de junho de 2004 a junho de 2009, na Universidade Federal de Santa Maria (UFSM), no Rio Grande do Sul. A coordenação foi realizada pela professora Elisete Medianeira Tomazetti, vinculada ao Departamento de Metodologia e Ensino (MEN), do Centro Educação e responsável pelas disciplinas de Didática da Filosofia, Pesquisa para o Ensino de Filosofia e Estágio Curricular Supervisionado, do Curso de Filosofia da UFSM. Desde seu início o projeto contou com vários alunos do Curso de Filosofia da UFSM. Alguns se agregavam ao grupo durante certo período e assim que concluíam seu curso e precisavam buscar emprego, em outras localidades, acabavam deixando o grupo. Outros, devido a bolsas de iniciação científica, oriundas de diferentes editais, permaneceram durante todo o período de desenvolvimento da pesquisa, nas diferentes etapas. O desenvolvimento da pesquisa procurou sempre fomentar o interesse dos alunos em dar continuidade a seus estudos de pós-graduação strictu sensu, seguindo com pesquisas na mesma temática. Muitos trabalhos, a partir desta pesquisa, foram elaborados e apresentados pelos participantes do grupo de pesquisa em eventos da área, ajudando a fortalecer esse campo teórico, ainda com certa carência de estudos e pesquisa significativos no contexto brasileiro. Da mesma forma, a pesquisa ajudou tornar mais visível a problemática do ensino de filosofia na Escola Básica no contexto do Curso de Filosofia e do Programa de Pós-Graduação em Educação da UFSM, principalmente.
A FILOSOFIA COMO PEDAGÓGICA:
Authors: Pansarelli Daniel , Matos Hugo Allan
Published: April 2019

Partindo-se de uma leitura crítica da produção filosófica latinoamericana em geral e brasileira em particular, pautada em autores como Cruz Costa, Salazar Bondy e Severino, busca-se apresentar a possibilidade de compreensão da Filosofia como uma pedagógica da libertação, tendo como referência principal o pensamento de Enrique Dussel.