bluuebunny/crossref_metadata_2025 huggingface dataset:
Residual Elbow Instability Treated with a Submuscular Internal Joint Stabilizer: Prospective and Consecutive Series with a Minimum Follow-Up of 12 Months
Authors: De Crescenzo Angelo , Garofalo Raffaele , Celli Andrea
Published: November 2024

Background: The management of residual elbow instability is a challenging and compelling issue for treating physicians. To overcome inherent drawbacks of dynamic external fixators, the internal joint stabilizer (IJS) has been developed, achieving successful results, but it can sometimes cause local tenderness or anesthetic concerns in the subcutaneous layer. In addition, a bulky anconeus can pull the hardware away from the axis of rotation with an increase in the lever arm and potential issues. To address these issues, an alternative approach has been recently described in which the internal device is covered by the anconeus muscle, becoming submuscular, rather than subcutaneous. The aim of this study was to evaluate the effectiveness of this alternative approach to the IJS application in maintaining a concentric elbow during and after device removal in both acute and chronic scenarios. Methods: Prospective data collection was performed with consecutive patients who had residual elbow instability treated with an IJS (Skeletal Dynamics, Miami, FL) covered by the anconeus from January 2022 and with a minimum follow-up of 12 months. Results: At a medium follow-up of 16 months, the 16 patients selected had a mean arc of flexion–extension of 123° (range: 0–140°) and a mean pronation-supination arc of 150° (range: 80–80°). The mean MEPS and DASH scores were 90.3 ± 6.2 and 6.3 ± 5.3, respectively. At the last follow-up, elbow stability and concentric reduction were confirmed with radiographic and clinical examinations. Conclusions: With a minimum follow-up of 12 months, the present study supports the safety and efficacy of the internal device in a submuscular layer. The clinical outcomes and the rate of recurrent instability are comparable to those achieved with a classic subcutaneous position. Similarly, the complication rate is not affected, and removal surgery is no more aggressive than the classic approach.
Deep Infiltrating Endometriosis of the Left Ureter Managed with Laparoscopic Ureterolysis Combined with Allium Ureteral Self-Expandable Stent: A Case Report
Authors: Jozwik Marcin , Miłobędzka Magdalena , Wojtkiewicz Joanna , Neymeyer Jörg , Jakimiuk Artur , Jozwik Maciej
Published: November 2024

Introduction: In endometriosis, urinary tract involvement occurs in 1–5.5% of cases, where the ureter is affected in 9–23%. Unfortunately, endometriosis may remain asymptomatic even with significant anatomical progression. A delay in the diagnosis and treatment of ureteral endometriosis may result in hydronephrotic kidney damage and functional impairment. Methods: We present a case of a 36-year-old woman with a left ureteral stricture caused by deep infiltrating endometriosis accompanied by severe kidney-induced arterial hypertension. In March 2022, the patient underwent both laparoscopic excision/evaporation of deep infiltrating endometriosis from the left ovarian fossa and left ureterolysis, followed by an ureterorenoscopic dilatation of the left ureter via the placement of an Allium self-expandable stent. Results: This stent was successfully removed 18 months later. A computed tomography check-up confirmed normal ureteral patency with no signs of endometriosis. Elevated blood pressure also resolved. Conclusions: Deep infiltrating endometriosis can lead to asymptomatic yet serious complications. A successful treatment of ureteral endometriosis may require multidisciplinary management, including a simultaneous laparoscopic and ureterorenoscopic approach. Ureteral stent placement is a minimally invasive state-of-the-art solution for ureteral stricture(s) and should be considered the first choice in women of reproductive age suffering from ureteral deep infiltrating endometriosis.
Beyond the Liver: A Comprehensive Review of Strategies to Prevent Hepatocellular Carcinoma
Authors: Polpichai Natchaya , Saowapa Sakditad , Danpanichkul Pojsakorn , Chan Shu-Yen , Sierra Leandro , Blagoie Johanna , Rattananukrom Chitchai , Sripongpun Pimsiri , Kaewdech Apichat
Published: November 2024

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, primarily developing in the context of chronic liver disease. Traditional prevention has focused on liver-specific interventions like antiviral therapies and surveillance. However, extrahepatic factors also significantly contribute to HCC risk. This review explores comprehensive strategies for HCC prevention, including both hepatic and extrahepatic factors. Methods: An extensive literature search of peer-reviewed articles up to October 2024 was conducted, focusing on studies addressing HCC prevention strategies. Studies that focused on both hepatic and extrahepatic factors were included. Data were extracted and synthesized to provide an overview of current prevention strategies and their effectiveness in reducing HCC incidence. Results: Hepatitis B vaccination and antiviral treatments for hepatitis B and C significantly reduce HCC incidence. Lifestyle modifications—such as reducing alcohol consumption, maintaining a healthy weight through diet and exercise, and smoking cessation—are crucial in lowering HCC risk. Environmental measures to limit exposure to aflatoxins and other hazards also contribute to prevention. Regular surveillance of high-risk groups enables early detection and improves survival rates. Emerging strategies like immunotherapy and gene therapy show potential for further reducing HCC risk. Conclusions: A comprehensive approach combining medical interventions, lifestyle changes, and environmental controls is essential for effectively decreasing HCC incidence globally. Implementing these combined measures could significantly reduce the global burden of HCC.
Proprioceptive Training Improves Postural Stability and Reduces Pain in Cervicogenic Headache Patients: A Randomized Clinical Trial
Authors: Emam Mohamed Abdelaziz , Hortobágyi Tibor , Horváth András Attila , Ragab Salma , Ramadan Magda
Published: November 2024

Background: Headache is one of the leading causes of disability in the world. Neck proprioception, pain, and postural control are interconnected in both healthy individuals and those with chronic neck pain. This study examines the effects of proprioceptive training using a gaze direction recognition task on postural stability and pain in cervicogenic headache patients. Methods: Patients with cervicogenic headache (n = 34, age: 35–49 y) were randomized into a control group (CON), receiving only selected physical therapy rehabilitation or to an experimental group (EXP), performing proprioceptive training using a gaze direction recognition task plus selected physical therapy rehabilitation. Both programs consisted of 24, 60 min long sessions over 8 weeks. Postural stability was assessed by the modified clinical test of sensory integration of balance (mCTSIB) and a center of pressure test (COP) using the HUMAC balance system. Neck pain was assessed by a visual analog scale. Results: In all six tests, there was a time main effect (p < 0.001). In three of the six tests, there were group by time interactions so that EXP vs. CON improved more in postural stability measured while standing on foam with eyes closed normalized to population norms, COP velocity, and headache (all p ≤ 0.006). There was an association between the percent changes in standing on foam with eyes closed normalized to population norms and percent changes in COP velocity (r = 0.48, p = 0.004, n = 34) and between percent changes in COP velocity and percent changes in headache (r = 0.44, p = 0.008, n = 34). Conclusions: While we did not examine the underlying mechanisms, proprioceptive training in the form of a gaze direction recognition task can improve selected measures of postural stability, standing balance, and pain in cervicogenic headache patients.
Advancing Adult-Acquired Flatfoot Deformity Treatment: Enhanced Biomechanical Support Through Graphene Oxide-Integrated Bioengineered Grafts Tested In Silico
Authors: Nieto Sebastián , Gantiva-Díaz Mónica , Hoyos María A. , Montoya Yuliet , Cruz Juan C. , Cifuentes-De la Portilla Christian
Published: November 2024

Adult-Acquired Flatfoot Deformity (AAFD) is a progressive orthopedic condition causing the collapse of the foot’s medial longitudinal arch, often linked with injuries to the plantar arch’s passive stabilizers, such as the spring ligament (SL) and plantar fascia. Conventional treatment typically involves replacing the SL with synthetic material grafts, which, while providing mechanical support, lack the biological compatibility of native ligaments. In response to this shortcoming, our study developed an electrospun, twisted polymeric graft made of polycaprolactone (PCL) and type B gelatin (GT), enhanced with graphene oxide (GO), a two-dimensional nanomaterial, to bolster biomechanical attributes. The addition of GO aimed to match the native ligamentous tissue’s mechanical strength, with the PCL-GT-GO 2.0% blend demonstrating an optimal Young’s modulus of 240.75 MPa. Furthermore, the graft showcased excellent biocompatibility, evidenced by non-hemolytic reactions, suitable wettability and favorable platelet aggregation—essential features for promoting cell adhesion and proliferation. An MTT assay revealed cell viability exceeding 80% after 48 h of exposure, highlighting the potential of the graft as a regenerative scaffold for affected ligaments. Computational modeling of the human foot across various AAFD stages assessed the graft’s in situ performance, with the PCL-GT-OG 2.0% graft efficiently preventing plantar arch collapse and offering hindfoot pronator support. Our study, based on in silico simulations, suggests that this bioengineered graft holds significant promise as an alternative treatment in AAFD surgery, marking a leap forward in the integration of advanced materials science for enhanced patient care.
Performance Analysis of FFF-Printed Carbon Fiber Composites Subjected to Different Annealing Methods
Authors: Butt Javaid , Khan Md Ashikul Alam , Adnan Muhammad , Mohaghegh Vahaj
Published: November 2024

Annealing is a popular post-process used to enhance the performance of parts made by fused filament fabrication. In this work, four different carbon-fiber-based composites were subjected to two different annealing methods to compare their effectiveness in terms of dimensional stability, surface roughness, tensile strength, hardness, and flexural strength. The four materials include PLA-CF, PAHT-CF, PETG-CF, and ABS-CF. The annealing methods involved heating the printed composites inside an oven in two different ways: placed on a tray and fluidized bed annealing with sharp sand. Annealing was conducted for a one-hour time interval at different annealing temperatures selected as per the glass transition temperatures of the four materials. The results showed that oven annealing provides better results under all scenarios except dimensional stability. PETG-CF and ABS-CF composites were significantly affected by oven annealing with expansion along the z-axis as high 8.42% and 18% being observed for PETG-CF and ABS-CF, respectively. Oven annealing showed better surface finish due to controlled and uniform heating, whereas the abrasive nature of sand and contact with sand grains caused inconsistencies on the surface of the composites. Sand annealing showed comparable hardness values to oven annealing. For tensile and flexural testing, sand annealing showed consistent values for all cases but lower than those obtained by oven annealing. However, oven annealing values started to decrease at elevated temperatures for PETG-CF and ABS-CF. This work offers a valuable comparison by highlighting the limitations of conventional oven annealing in achieving dimensional stability. It provides insights that can be leveraged to fine-tune designs for optimal results when working with different FFF-printed carbon-fiber-based composites, ensuring better accuracy and performance across various applications.
Evidence of 2024 Summer as the Warmest During the Last Four Decades in the Aegean, Ionian, and Cretan Seas
Authors: Androulidakis Yannis , Kolovoyiannis Vassilis , Makris Christos , Krestenitis Yannis
Published: November 2024

The summer of 2024 witnessed record-high sea surface temperatures (SST) across the Aegean, Ionian, and Cretan Seas (AICS), following unprecedented air heatwaves over the sea under a long-term warming trend of 0.46 °C/decade for the mean atmospheric temperature (1982–2024). The respective mean SST trend for the same period is even steeper, increasing by 0.59 °C/decade. With mean summer surface waters surpassing 28 °C, particularly in the Ionian Sea, the southern Cretan, and northern Aegean basins, this summer marked the warmest ocean conditions over the past four decades. Despite a relatively lower number of marine heatwaves (MHWs) compared to previous warm years, the duration and cumulative intensity of these events in 2024 were the highest on record, reaching nearly twice the levels seen in 2018, which was the warmest until now. Intense MHWs were recorded, especially in the northern Aegean, with extensive biological consequences to ecosystems like the Thermaikos Gulf, a recognized MHW hotspot. The strong downward atmospheric heat fluxes in the summer of 2024, following an interannual increasing four-decade trend, contributed to the extreme warming of the water masses together with other met-ocean conditions such as lateral exchanges and vertical processes. The high temperatures were not limited to the surface but extended to depths of 50 m in some regions, indicating a deep and widespread warming of the upper ocean. Mechanisms typically mitigating SST rises, such as the Black Sea water (BSW) inflow and coastal upwelling over the eastern Aegean Sea, were weaker in 2024. Cooler water influx from the BSW decreased, as indicated by satellite-derived chlorophyll-a concentrations, while upwelled waters from depths of 40 to 80 m at certain areas showed elevated temperatures, likely limiting their cooling effects on the surface. Prolonged warming of ocean waters in a semi-enclosed basin such as the Mediterranean and its marginal sea sub-basins can have substantial physical, biological, and socioeconomic impacts on the AICS. This research highlights the urgent need for targeted monitoring and mitigation strategies to address the growing impact of MHWs in the region.
Predefined-Time Hybrid Tracking Control for Dynamic Positioning Vessels Based on Fully Actuated Approach
Authors: Xu Yujie , Wang Yingjie , Fu Mingyu , Chen Hao
Published: November 2024

This study investigates the problem of tracking the trajectory of a dynamic positioning (DP) ship under sudden surges of elevated sea states. First, the tracking problem is reformulated as an error calibration problem through the introduction of fully actuated system (FAS) approaches, thereby simplifying controller design. Second, a predefined-time control term is designed to maintain the convergence time of the trajectory tracking error within a specified range; however, the upper bound of the perturbation must be estimated in advance. The high sea state during operation can result in an abrupt change in the upper bound of disturbance, thereby affecting the control accuracy and stability of the system. Therefore, a linear control matrix is developed to eliminate the system’s dependence on the estimation of the upper bound of disturbance following smooth switching, thereby achieving control decoupling and providing a conservative switching time. Additionally, a nonlinear reduced-order expansion observer (RESO) is constructed for feedforward compensation. The stability of the system is demonstrated using the Lyapunov function, indicating that the selection of appropriate poles can theoretically enhance the system’s convergence with greater control accuracy and robustness after switching. Finally, the effectiveness of the proposed method is validated through simulations and comparative experiments.
Crude Oil Biodegradation by a Biosurfactant-Producing Bacterial Consortium in High-Salinity Soil
Authors: Chen Weiwei , Sun Jiawei , Ji Renping , Min Jun , Wang Luyao , Zhang Jiawen , Qiao Hongjin , Cheng Shiwei
Published: November 2024

Bioremediation is a promising strategy to remove crude oil contaminants. However, limited studies explored the potential of bacterial consortia on crude oil biodegradation in high salinity soil. In this study, four halotolerant strains (Pseudoxanthomonas sp. S1-2, Bacillus sp. S2-A, Dietzia sp. CN-3, and Acinetobacter sp. HC8-3S), with strong environmental tolerance (temperature, pH, and salinity), distinctive crude oil degradation, and beneficial biosurfactant production, were combined to construct a bacterial consortium. The inoculation of the consortium successfully degraded 97.1% of total petroleum hydrocarbons in 10 days, with notable removal of alkanes, cycloalkanes, branched alkanes, and aromatic hydrocarbons. Functional optimization showed that this consortium degraded crude oil effectively in a broad range of temperature (20–37 °C), pH (6–9), and salinity (0–100 g/L). In salt-enriched crude-oil-contaminated soil microcosms, the simultaneous treatment of bioaugmentation and biostimulation achieved the highest crude oil degradation rate of 568.6 mg/kg/d, compared to treatments involving abiotic factors, natural attenuation, biostimulation, and bioaugmentation after 60 days. Real-time PCR targeting the 16S rRNA and alkB genes showed the good adaptability and stability of this consortium. The degradation property of the constructed bacterial consortium and the engineered consortium strategy may have potential use in the bioremediation of crude oil pollution in high-salinity soil.
Seepage–Diffusion Mechanism of Gas Kick Considering the Filtration Loss of Oil-Based Muds During Deepwater Drilling
Authors: Guo Yanli , Liu Weiqi , Song Chaojie , Gong Qingtao , Teng Yao
Published: November 2024

As oil and gas exploration gradually advances into deep waters, the combined effects of various types of gas kick and the accurate calculation of the gas-kick volume have gained increasing attention. This study focused on gas kicks from permeable gas-bearing formations, considering the mass transfer of gas in the filtration region of the drilling fluids and revealed the mechanisms of seepage-driven and diffusion-driven gas kicks. Based on seepage mechanics and diffusion theory, a comprehensive model for calculating gas-kick volume was established, considering the synergistic effect of gas-concentration-diffusion and negative-differential-pressure, as well as mass transfer in both the filtrate zone and the filter-cake zone. The new model showed high calculation accuracy. The sensitivity analysis showed that both the seepage-driven and diffusion-driven gas-kick volumes in the wellbore increased with increasing formation porosity and open-hole length, while the thickness of the filter cake had a strong inhibitory effect on both. Additionally, a “seepage–diffusion ratio” was introduced to reveal the gas-kick evolution pattern under a seepage–diffusion mechanism. Under specific case conditions, when the seepage–diffusion ratio was less than approximately 1%, diffusion-driven gas kick contributed more than seepage-driven gas kick; when the seepage–diffusion ratio exceeded 1%, seepage-driven gas kick contributed more than diffusion-driven gas kick. The research can provide crucial parameters for wellbore multiphase flow calculation and wellbore pressure prediction.
Experimental and Numerical Analysis of PIP Slip Joint Subjected to Bending
Authors: Islam Md Ariful , Park Hongbae , Lee Daeyong
Published: November 2024

Detachable circular hollow sections (CHSs) offer an innovative solution to tackle the complexities of installation, maintenance, upgrades, and repairs in offshore monopile systems, particularly in challenging environments with limited access. As an alternative to traditional tubular joints, the PIP slip joint presents advantages in terms of ease of installation, time efficiency, and reduced susceptibility to failure. This study conducts an experimental investigation on PIP (Pile-in-Pile) slip joints under pure bending conditions, accompanied by comprehensive numerical analyses to examine the relationship between section slenderness, contact properties, and structural performance. The results highlight a strong correlation between force-displacement curves and include a comparison of compressive and tensile strain values for both experimental and numerical models. The experimental and numerical models showed strong agreement across all results, demonstrating the robustness of the findings. Additionally, numerical models were utilized to investigate various D/t ratios, revealing insights into the normalized moment, rotational capacity, and the impact of local buckling and contact mechanics. Furthermore, a comparison of these findings with established code guidelines, such as Eurocode and AISC-LRFD, has been conducted and reviewed in the context of this study. From analysis, it was found that the rise in the D/t ratio prompted a transformation in the buckling mode, which substantially altered the rotational ratio. This shift indicates the importance of understanding how these variables interact in engineering applications. These findings significantly enhance the understanding of PIP slip joints and emphasize their potential as a compelling alternative for offshore wind turbine support structures.
Application of Hyperspectral Image for Monitoring in Coastal Area with Deep Learning: A Case Study of Green Algae on Artificial Structure
Authors: Kim Tae-Ho , Min Jee Eun , Lee Hye Min , Kim Kuk Jin , Yang Chan-Su
Published: November 2024

Remote sensing is a powerful technique for classifying and quantifying objects. However, the elaborate classification of objects in coastal waters with complex structures is still challenging due to the high possibility of class mixing. The classification through the hyperspectral images can be a reasonable alternative to problems related to such precise classification work because it has high spectral resolution over a wide bandwidth. This study introduced the results of the case study using a novel method to classify green algae on an artificial structure based on hyperspectral data and deep-learning models. The spectral characteristics of the attached green algae on the artificial structure were observed using a ground-based hyperspectral camera. The observed image had a total of three classes (concrete, dense green algae, and sparse green algae). A certain area of the image was used as learning data to create classification models for three classes. The classification models were created from one machine-learning (support vector machine, SVM) and two deep-learning models (convolutional neural network, CNN; and dense convolutional network, DenseNet). As a result, the performance for the classification results of green algae predicted from two deep-learning models was higher than that of the machine-learning model. Additionally, the deep-learning model successfully classified the interface area between concrete and green algae. This study suggests that the combination of hyperspectral data and deep learning could enable more precise classification of objects in coastal areas.
Differential Inflammatory and Immune Response to Viral Infection in the Upper-Airway and Peripheral Blood of Mild COVID-19 Cases
Authors: Gajate-Arenas Malena , García-Pérez Omar , Domínguez-De-Barros Angélica , Sirvent-Blanco Candela , Dorta-Guerra Roberto , García-Ramos Alma , Piñero José E. , Lorenzo-Morales Jacob , Córdoba-Lanús Elizabeth
Published: November 2024

Background/Objectives: COVID-19 is characterised by a wide variety of clinical manifestations, and clinical tests and genetic analysis might help to predict patient outcomes. Methods: In the current study, the expression of genes related to immune response (CCL5, IFI6, OAS1, IRF9, IL1B, and TGFB1) was analysed in the upper airway and paired-blood samples from 25 subjects infected with SARS-CoV-2. Relative gene expression was determined by RT-qPCR. Results: CCL5 expression was higher in the blood than in the upper airway (p < 0.001). In addition, a negative correlation was found between IFI6 and viral load (p = 0.033) in the upper airway, suggesting that the IFI6 expression inhibits the viral infection. Concerning sex, women expressed IL1B and IRF9 in a higher proportion than men at a systemic level (p = 0.008 and p = 0.049, respectively). However, an increased expression of IRF9 was found in men compared to women in the upper airway (p = 0.046), which could be due to the protective effect of IRF9, especially in men. Conclusions: The higher expression of CCL5 in blood might be due to the key role of this gene in the migration and recruitment of immune cells from the systemic circulation to the lungs. Our findings confirm the existence of sex differences in the immune response to early stages of the infection. Further studies in a larger cohort are necessary to corroborate the current findings.
Rockfall Mapping and Monitoring Across the Kalymnos Sport Rock Climbing Sites, Based on Ultra-High-Resolution Remote Sensing Data and Integrated Simulations
Authors: Vassilakis Emmanuel , Konsolaki Aliki , Soukis Konstantinos , Laskari Sofia , Kotsi Evelina , Lialiaris John , Lekkas Efthymios
Published: November 2024

This manuscript presents a multidisciplinary study that proposes a methodology for delineating and categorizing vulnerability at rockfall risk areas to avoid human injuries and infrastructure damage caused by rockfalls. The presented workflow includes (i) classical geological mapping, (ii) the interpretation of high-resolution satellite data for observing the spatial distribution of fallen boulders, (iii) analytical hierarchy processing of spatial information within a Geographical Information System (GIS) platform, (iv) close-range remote sensing campaigns with Unmanned Aerial Systems (UASs), and (v) integrated simulation of rockfall events. This methodology was applied to Kalymnos Island, which belongs to the Dodecanese Islands complex of the southeastern Aegean Sea in Greece. It is characterized by unique geomorphological features, including extensive vertical limestone cliffs that span the island. These cliffs make it one of the world’s most densely concentrated areas for sport climbing. The results highlighted the areas that the local authorities need to focus on and suggested measures for increasing the safety of climbers and infrastructure.
Analysis of the Wangping Brownfield Using a Two-Step Urban Brownfield Redevelopment Model
Authors: Liu Zhiping , Feng Yingxue , Li Jing , Tao Haoyu , Liu Zhen , Li Xiaodan , Hu Yue
Published: November 2024

With societal progress, urban brownfields have become restrictive, and redevelopment studies have become an important part of urban renewal. In this work, we developed a two-step model for urban brownfield redevelopment, while considering the Wangping brownfield as the study area. Site suitability evaluation models for brownfield parks, agricultural picking gardens, and creative industrial centers were developed based on the elevation, slope, and surface runoff, and the evaluation results were categorized into five levels. The redevelopment plan was formulated based on these evaluation results. To study the effect of the plan, a transition matrix of land use was assessed using satellite images and the cellular automata (CA)–Markov model; based on the analysis, we predicted the land use situation of the Wangping brownfield, with respect to natural development, for 2030. A comparison of the redevelopment planning with the forecasted results revealed that the proportions of grassland, construction, and unused land decreased by 25.68, 3.12, and 2.38% and those of plowland and forest land increased by 6.61 and 24.57%. This confirms the advantages of redevelopment planning for restoring plowland and increasing biological carbon sinks. Notably, our two-step urban brownfield redevelopment model can enrich the current research on urban brownfields and guide similar urban renewal projects.
Aggregated Housing Price Predictions with No Information About Structural Attributes—Hedonic Models: Linear Regression and a Machine Learning Approach
Authors: Jaroszewicz Joanna , Horynek Hubert
Published: November 2024

A number of studies have shown that, in hedonic models, the structural attributes of real property have a greater influence on price than external attributes related to location and the immediate neighbourhood. This makes it necessary to include detailed information about structural attributes when predicting prices using regression models and machine learning algorithms and makes it difficult to study the influence of external attributes. In our study of asking prices on the primary residential market in Warsaw (Poland), we used a methodology we developed to determine price indices aggregated to micro-markets, which we further treated as a dependent variable. The analysed database consisted of 10,135 records relating to 2444 residential developments existing as offers on the market at the end of each quarter in the period 2017–2021. Based on these data, aggregated price level indices were determined for 503 micro-markets in which primary market offers were documented. Using the analysed example, we showed that it is possible to predict the value of aggregated price indices based only on aggregated external attributes—location and neighbourhood. Depending on the model, we obtained an R2 value of 75.8% to 82.9% for the prediction in the set of control observations excluded from building the model.
A Severe Case of Plasmodium falciparum Malaria in a 44-Year-Old Caucasian Woman on Return to Western Romania from a Visit to Nigeria
Authors: Mihu Alin Gabriel , Lighezan Rodica , Oatis Daniela Adriana , Mederle Ovidiu Alexandru , Petrine-Mocanu Cristina , Petrescu Cristina , Prisca Mirandolina Eugenia , Ghenciu Laura Andreea , Avram Cecilia Roberta , Lupu Maria Alina , Bica Adelaida , Olariu Tudor Rareș
Published: November 2024

Malaria is currently the most prevalent life-threatening infectious disease in the world. In this case report, we present a 44-year-old Caucasian woman with a low level of education and no significant past medical history who presented to the emergency room of the Emergency County Hospital of Arad, Romania, with a general affected state, a fever of 38.5 °C, chills, weakness, headache, muscle pain, nausea, icterus, and watery diarrheal stool. A viral infection was initially suspected, and the patient was transferred to the Infectious Diseases Department. The anamnesis revealed that the patient traveled to Nigeria (Ado Ekiti) and returned to Romania 14 days before presenting to the hospital without following antimalarial prophylaxis. A peripheral blood smear was conducted and revealed parasitemia with ring forms of Plasmodium falciparum (P. falciparum) of 10–15% within the red blood cells. Parasitemia increased within a day to 15–18%, and her health rapidly deteriorated. She was transferred to the Victor Babeș Infectious Disease Hospital in Bucharest for the urgent initiation of antimalarial treatment. The patient’s condition continued to worsen rapidly, and she succumbed to her illness due to multi-organ failure. This report details the first documented case of malaria imported from Nigeria to Romania. People traveling to malaria-endemic areas should be educated about preventing this parasitic infection, both by adopting measures to reduce the risk of mosquito bites and by using appropriate chemoprophylaxis. In the context of resuming travel after the COVID-19 pandemic, understanding and adhering to prophylactic measures is crucial to avoid tragic situations, as highlighted in this case report.
Comparative Analysis of Microbiota in Jiani Yaks with Different Rib Structures
Authors: Cidan Yangji , Lu Sijia , Wang Hongzhuang , Wang Jia , Ali Munwar , Fouad Dalia , Ataya Farid S. , Zhu Yanbin , Basang Wangdui , Li Kun
Published: November 2024

The Jiani yak is a nationally renowned species that is known for its meat which is rich in various minerals, amino acids, and proteins. The rumen microbiota plays a critical role in gastrointestinal health and feed degradation, contributing proteins, lipids, and volatile fatty acids (VFAs) essential for milk and meat production. However, there is limited knowledge about the microbiota of free-ranging Jiani yaks, especially those with 15 ribs. Rumen fluid samples were collected from yaks with 14 (PL) ribs and 15 (DL) ribs from a slaughterhouse in Jiani County, China. The total DNA of rumen fluid microorganisms was extracted for microbiota sequencing. Our results revealed 643,713 and 656,346 raw sequences in DL and PL animals, respectively, with 611,934 and 622,814 filtered sequences in these two yak groups. We identified 13,498 Amplicon Sequence Variants (ASVs), with 2623 shared between DL and PL animals. The ratio of Bacteroidota to Firmicutes differed between PL (3.04) and DL (2.35) animals. Additionally, 6 phyla and 21 genera showed significant differences between yaks with 14 and 15 ribs, leading to altered microbiota functions, with 51 and 35 notably different MetaCyc and KEGG pathways, respectively. Hence, the microbiota of yaks with 15 ribs differs from those with 14 ribs. Therefore, these microbiota-related comparative investigations will provide insights into yak husbandry practices and genetic selection strategies for their improved productivity in harsh environments.
Acromegaly in Speckle Tracking Echocardiography—A New Cardiac Hypertrophy Phenotype? Case Report and Review
Authors: Suchodolski Alexander , Wójcik-Giertuga Monika , Kos-Kudła Beata , Szulik Mariola
Published: November 2024

Background: This study aims to provide a comprehensive overview of speckle tracking echocardiography (STE) findings in patients diagnosed with acromegaly, exploring a potential application for the differential diagnosis of cardiac hypertrophy and guiding clinicians in patient management. To our knowledge, this is the first review showcasing changes in the bull’s-eye pattern in myocardial function after acromegaly treatment, suggesting a possible pattern in this aetiology of left ventricular hypertrophy. Methods: A review of PubMed articles using the search term “speckle tracking echocardiography acromegaly” yielded 11 relevant papers published between 2017 and 2023. The final analysis evaluated each paper’s substantial value and summarised pertinent information. A clinical case of myocardial strain changes before and after pharmacological and neurosurgical treatment is also described. Results: The 11 analysed papers, with patient groups ranging from 19 to 50 individuals, revealed varying results in STE parameters between acromegalic and control groups. Left ventricular strain parameters were commonly assessed, showing discrepancies in different studies. Notably, the MAGYAR-Path Study emphasised left ventricular twist and radial strain abnormalities in acromegaly patients. Furthermore, the interplay between acromegaly and diabetes influenced myocardial function. Drug treatment with somatostatin receptor ligands demonstrated a favourable impact on left ventricular systolic function. The case study we describe in this manuscript showed changes in the posterior basal LV segment, which may be a specific pattern of acromegaly remodelling. Somatostatin therapy and neurosurgery led to the normalisation of global longitudinal strain (GLS) and improvement in myocardial work, as well as improved diastolic function, including enhanced left atrial strain (LAS) as well as a visible elastic recoil sign (ERS). Conclusions: While the available literature on STE in acromegaly is limited, our analysis suggests potential applications in differentiating hypertrophy aetiologies and monitoring cardiac function post-treatment. The results underscore the need for more interdisciplinary research to optimise patient management. The bull’s-eye pattern with posterior basal segment strain impairment we describe may be used to differentiate this entity.
Influence of Lifestyle Factors on Ocular Surface Parameters in Relation to Age
Authors: Garcia-Queiruga Jacobo , Pena-Verdeal Hugo , Sabucedo-Villamarin Belen , Noya-Padin Veronica , Giraldez Maria J. , Yebra-Pimentel Eva
Published: November 2024

Purpose: To evaluate how Video Display Terminal (VDT) use, Contact Lens (CL) wear, and eyedrop use affect ocular surface parameters in participants with ocular discomfort and how these factors may vary across different age groups. Methods: The current cross-sectional study initially involved a total of 252 participants who completed a self-administered survey to collect information about ocular discomfort and lifestyle factors. This online survey was composed of an Ocular Surface Disease Index (OSDI) questionnaire and three extra questions regarding lifestyle factors (VDT use, CL wear, and eyedrop use). Only 185 symptomatic participants, those with OSDI values > 12, were scheduled to undergo a comprehensive ocular examination that included tear film osmolarity, Fluorescein Break-Up Time (FBUT), Maximum Blink Interval (MBI), and corneal staining. Results: Differences in ocular parameters and lifestyle factors across age groups (<40 years, 40–60 years, >60 years) were analyzed, along with their correlations and regression. Significant age group differences were found in OSDI, osmolarity, FBUT, and MBI (One-way ANOVA, all p ≤ 0.029). Correlations were observed between CL wear and osmolarity and MBI (Pearson’s correlation, both p ≤ 0.049). Multiple regression confirmed age associations with OSDI, osmolarity, FBUT, and MBI (Multiple linear regression, all p ≤ 0.040) and found links between VDT use and osmolarity and MBI (Multiple linear regression, both p ≤ 0.038) and between eyedrop use and OSDI (Multiple linear regression, p = 0.040). Conclusion: Aging is a primary factor affecting ocular homeostasis, with older adults showing lower FBUT and MBI values and higher osmolarity. Prolonged use of VDTs exacerbates this effect, further contributing to ocular discomfort and destabilized tear film. No associations between CL wear and any of the ocular parameters were found. Eyedrop use shows varied effects on ocular comfort across age groups, emphasizing the need for age-specific ocular care. Overall, these findings confirm that aging and extended VDT use play a significant role in ocular surface discomfort.
Poly (Propylene Carbonate) with Extremely Alternating Structure Used as Binders for High-Loading Cathodes by Solvent-Free Method in High-Performance NCM811 Batteries
Authors: Zhang Zhe , Ma Jinyin , Xiao Min , Wang Shuanjin , Huang Sheng , Guo Hui , Han Dongmei , Meng Yuezhong
Published: November 2024

The cathode affects the capacity, working voltage, and cost of lithium-ion batteries. Although the binder is a small part of the cathode material, it is particularly important to the performance of the batteries. Therefore, the design and development of polymer binders with different structures and characteristics is an important topic. In this paper, an NCM811 cathode (PPC-NCM) was prepared by a solvent-free method using poly (propylene carbonate) (PPC) as the binder, with an active substance loading of 10 mg/cm2. To explore the effect of the PPC binder on the electrochemical performance of the NCM811 cathode, the discharge capacity was 112.2 mAh/g with a 76.1% capacity retention after cycling more than 200 cycles at 1 C, which has a significantly better cycling performance than that of a PVDF-NCM/Li battery. The PPC/NCM/graphite full cells were also assembled to demonstrate the practical application potential of this work. It was shown that PPC as a binder can improve the cycling stability of NCM811/Li and NCM811/graphite full cells. The PPC binder used in the NCM811 cathode not only makes it extremely easy to prepare dry electrodes, but also makes it very simple to recover the electrode material by heating in the case of battery failure. This paper provides a new idea for the industrialization and development of a novel binder.
Evaluation of SMA-13 Asphalt Mixture Reinforced by Different Types of Fiber Additives
Authors: Wu Haochen , Xiao Peng , Fei Ziyun , Kang Aihong , Wu Xing
Published: November 2024

This research aims at systematically evaluating the properties of SMA-13 asphalt mixture reinforced by several fiber additives including flocculent lignin fiber (FLF), granular lignin fiber (GLF), chopped basalt fiber (CBF), and flocculent basalt fiber (FBF). Firstly, the thermal stability, moisture absorption, and oil absorption property of these fiber additives were analyzed. Secondly, the property of SMA-13 reinforced using four types of single fibers and two kinds of composite fibers (FLF + CBF and FLF + FBF) was comprehensively analyzed. Specifically, the high-temperature performance was evaluated using the uniaxial penetration test and the rutting test, the medium-temperature anticracking property was evaluated using the IDEAL-CT test, the low-temperature property was analyzed using the beam bending test, and the water stability was studied by the freeze–thaw splitting test. Thirdly, the dynamic mechanical response of different-fibers-modified SMA-13 was evaluated using the uniaxial compression dynamic modulus test. Finally, correlation analysis between the results of dynamic modulus and the high-, medium-, and low-temperature mechanical performance was carried out. The research results reveal that the stability of CBF and FBF under thermal action is better than that of GLF and FLF, and FBF shows the best thermal stability. The oil absorption property of FLF is better than that of GLF, followed by FBF and CBF. The comprehensive mechanical properties of CBF- and FBF-reinforced SMA-13 are better than those of FLF- and GLF-modified SMA-13. CBF can better reinforce the mechanical property of SMA-13 under low and medium temperature, while FBF can better reinforce the performance of SMA-13 at high temperature. FLF/CBF- and FLF/FBF-composite-modified SMA-13 show better high-temperature mechanical performance than that of the single-fiber-reinforced mixture, and FLF has some negative impact on the properties of FLF/FBF-composite-modified SMA-13 at low temperature. Fibers have no significant influence on the water stability of the mixtures. Meanwhile, the linear correlation between the mechanical performance of all the fiber-reinforced SMA-13 and the dynamic modulus result is good.
Numerical and Experimental Research of the Plastic Forming Process of Hastelloy X Alloy Sheets Using Elastomeric and Steel Tools
Authors: Żaba Krzysztof , Balcerzak Maciej , Trzepieciński Tomasz , Kuczek Łukasz , Nowak Vit , Mizera Jarosław , Sitek Ryszard
Published: November 2024

The results of experimental and numerical studies of plastic forming of sheets made of the difficult-to-deform Hastelloy X, a nickel-based alloy with a thickness of 1 mm, using layered elastomeric punches and steel dies, are presented in this publication. The elastomeric punches were characterized by hardness in the range of 50–90 Shore A, while the dies were made of 90MnCrV8 steel with a hardness of over 60 HRC. The principle of operating the stamping die was based on the Guerin method. The finite-element-based numerical modeling of the forming process for various configurations of polyurethane inserts was also carried out. The results obtained from numerical modeling were confirmed by the results of experimental tests. The drawpieces obtained through sheet forming were subjected to geometry tests using optical 3D scanning. The results confirmed that in the case of forming difficult-to-deform Hastelloy X, Ni-based alloy sheets, the hardness of the polyurethane inserts significantly affected the geometric quality of the obtained drawpieces. Significant nonuniform sheet metal deformations were also found, which may pose a problem in the process of designing forming tools and the technology of the plastic forming of Hastelloy X, Ni-based alloy sheets.
Thermoplastic Starch with Maltodextrin: Preparation, Morphology, Rheology, and Mechanical Properties
Authors: Rana Lata , Kouka Saffana , Gajdosova Veronika , Strachota Beata , Konefał Magdalena , Pokorny Vaclav , Pavlova Ewa , Stary Zdenek , Lukes Jaroslav , Patocka Marek , Hegrova Veronika , Fortelny Ivan , Slouf Miroslav
Published: November 2024

This work describes the preparation of highly homogeneous thermoplastic starches (TPS’s) with the addition of 0, 5, or 10 wt.% of maltodextrin (MD) and 0 or 3 wt.% of TiO2 nanoparticles. The TPS preparation was based on a two-step preparation protocol, which consisted in solution casting (SC) followed by melt mixing (MM). Rheology measurements at the typical starch processing temperature (120 °C) demonstrated that maltodextrin acted as a lubricating agent, which decreased the viscosity of the system. Consequently, the in situ measurement during the MM confirmed that the torque moments and real processing temperatures of all TPS/MD systems decreased in comparison with the pure TPS. The detailed characterization of morphology, thermomechanical properties, and local mechanical properties revealed that the viscosity decrease was accompanied by a slight decrease in the system homogeneity. The changes in the real processing temperatures might be quite moderate (ca 2–3 °C), but maltodextrin is a cheap and easy-to-add modifier, and the milder processing conditions are advantageous for both technical applications (energy savings) and biomedical applications (beneficial for temperature-sensitive additives, such as antibiotics).
Silibinin-Loaded Amphiphilic PLGA–Poloxamer Nanoparticles: Physicochemical Characterization, Release Kinetics, and Bioactivity Evaluation in Lung Cancer Cells
Authors: Villapiano Fabrizio , Piccioni Miriam , D’Aria Federica , Crispi Stefania , Rassu Giovanna , Giunchedi Paolo , Gavini Elisabetta , Giancola Concetta , Serri Carla , Biondi Marco , Mayol Laura
Published: November 2024

Despite its potential against several carcinomas, the pharmacological efficacy of silibinin (SLB) is hampered by poor solubility, absorption, and oral bioavailability. To face these issues, we developed polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) coated with hydrophilic polyethene oxide (PEO) for controlled and targeted SLB delivery. NPs were produced at two different SLB loadings and presented a spherical shape with smooth surfaces and stable size in water and cell culture medium. The encapsulation efficiencies were found to be >84%, and thermal analysis revealed that the SLB was present in an amorphous state within the NPs. In vitro SLB release experiments revealed that at the lowest SLB loading, desorption of the active molecule from the surface or nanoporosities of the NPs mainly dictates release. In contrast, at the highest SLB loading, diffusion primarily regulates release, with negligible contributions from other mechanisms. Cell experiments showed that, compared with the free drug, SLB loaded in the produced NPs significantly increased the bioactivity against H1299, H1975, and H358 cells.