bluuebunny/crossref_metadata_2025 huggingface dataset:
Silent and dangerous: catheter-associated right atrial thrombus (CRAT) in children on chronic haemodialysis
Authors: Garcia-Nicoletti Martin , Sinha Manish D. , Savis Alexandra , Adalat Shazia , Karunanithy Narayan , Calder Francis
Published: October 2020

Background

Catheter-associated right atrial thrombus (CRAT) is a recognised complication of central venous catheter (CVC) use for haemodialysis (HD) patients.

Methods

This was a single-centre retrospective longitudinal observational study of consecutive children aged 6 months–18 years over a 7-year period receiving in-centre chronic HD. Echocardiograms as per routine cardiac surveillance were performed 6 months or earlier given clinical concerns.

Results

Sixty-five children, 36 boys (55.4%), median (IQR) age 11.8 (5.3, 14.7) years, received HD for kidney failure with replacement therapy (KFRT). Initial modality was HD in 45 (69.2%), with CVC as initial access in 42 (93.3%) and AVF in 3 (6.7%); in the remaining 20 (30.8%) patients PD was the initial modality before switching to HD. Seven of 65 (10.8%) developed CRAT at median 2 (0.8, 8.4) months from CVC insertion, with one CRAT detected 3 days following insertion. One child had 2 episodes of CRAT and one additionally thrombosed their AVF. No patient had an underlying primary kidney disease associated with a pro-thrombotic state. Those with CRAT were younger, had more frequent CVC change and received dialysis for longer duration compared to those with no CRAT. Six episodes of CRAT (75%) received anticoagulation therapy. Infective complications were observed in 25% and catheter malfunction in 50%. Five CRAT episodes (62.5%) resulted in CVC loss. One patient died after a haemorrhagic complication of anticoagulation and sepsis, and another developed life-threatening superior vena cava obstruction syndrome. Overall mortality 14% (1/7).

Conclusions

This is the first report of CRAT in a paediatric HD population. There was ~ 11% incidence of CRAT in patients receiving chronic HD detected by surveillance echocardiography. Although frequently asymptomatic, CRAT is associated with serious sequelae. Anticoagulation and surveillance with expert echocardiography remain mainstays of management.

Graphical abstract
“Do I want to know it all?” A qualitative study of glioma patients’ perspectives on receiving information about their diagnosis and prognosis
Authors: Malmström Annika , Åkesson Lisa , Milos Peter , Mudaisi Munila , Bruhn Helena , Strandeus Michael , Karlsson Marit
Published: October 2020

Purpose

Glioma patients have poor prognosis. The amount of detail of disease-related information patients wish to receive is not known. The aim of this study was to explore glioma patients’ experiences and preferences regarding receiving information on diagnosis and prognosis.

Methods

Semi-structured interviews were performed with patients diagnosed with glioma. The interviews were analysed by qualitative content analysis without predefined categories by two independent coders.

Results

Ten women and 15 men, with newly diagnosed grade II–IV glioma, age 25–76 years, were interviewed. Participants’ experience on diagnosis communication was either indirect, meaning they found out their diagnosis unintentionally, e.g., from their electronic health record (EHR) instead of from their doctor, this causing anxiety and feelings of abandonment, insufficiently tailored: lacking in many aspects or individualised and compassionate. Participants generally wanted to know “the truth” about diagnosis and prognosis, but what they meant varied; some desired full honest information to allow for autonomous choices, others preferred general information without details, and some wanted no bad news at all, only positive information. Participants disclosed vulnerability after receiving their diagnosis, being cast into the unknown. They expressed a need for better everyday practical information to help create some control. Supportive staff could reduce participants’ distress.

Conclusion

There is a need to further develop and implement individually tailored information to glioma patients, both in consultations and patient-accessed EHR systems, which should have safe guards for sensitive information. Not all patients want to know it all, one size does not fit all.
Botulinum toxin therapy of dystonia
Authors: Dressler Dirk , Adib Saberi Fereshte , Rosales Raymond L.
Published: October 2020

Botulinum toxin (BT) is used to treat a large number of muscle hyperactivity syndromes. Its use in dystonia, however, is still one of the most important indications for BT therapy. When BT is injected into dystonic muscles, it produces a peripheral paresis which is localised, well controllable and follows a distinct and predictable time course of around 3 months. Adverse effects are always transient and usually mild, long-term application is safe. With this profile BT can be used to treat cranial dystonia, cervical dystonia and limb dystonia including writer’s and musician's cramps. The recent introduction of BT high dose therapy also allows to treat more wide-spread dystonia including segmental and generalised dystonia. BT can easily be combined with other anti-dystonic treatments such as deep brain stimulation and intrathecal baclofen application. Best treatment results are obtained when BT therapy is integrated in the multimodal and long-term 'multilayer concept of treatment of dystonia'. The biggest challenge for the future will be to deliver state of the art BT therapy to all dystonia patients in need, regardless of whether they live in developed countries or beyond.
Near-optimal analysis of Lasserre’s univariate measure-based bounds for multivariate polynomial optimization
Authors: Slot Lucas , Laurent Monique
Published: October 2020

We consider a hierarchy of upper approximations for the minimization of a polynomial f over a compact set $$K \subseteq \mathbb {R}^n$$

K
⊆

R

n

proposed recently by Lasserre (arXiv:1907.097784, 2019). This hierarchy relies on using the push-forward measure of the Lebesgue measure on K by the polynomial f and involves univariate sums of squares of polynomials with growing degrees 2r. Hence it is weaker, but cheaper to compute, than an earlier hierarchy by Lasserre (SIAM Journal on Optimization 21(3), 864–885, 2011), which uses multivariate sums of squares. We show that this new hierarchy converges to the global minimum of f at a rate in $$O(\log ^2 r / r^2)$$

O
(

log
2

r
/

r
2

)

whenever K satisfies a mild geometric condition, which holds, eg., for convex bodies and for compact semialgebraic sets with dense interior. As an application this rate of convergence also applies to the stronger hierarchy based on multivariate sums of squares, which improves and extends earlier convergence results to a wider class of compact sets. Furthermore, we show that our analysis is near-optimal by proving a lower bound on the convergence rate in $$\varOmega (1/r^2)$$

Ω
(
1
/

r
2

)

for a class of polynomials on $$K=[-1,1]$$

K
=
[
-
1
,
1
]

, obtained by exploiting a connection to orthogonal polynomials.
Job Mobility and Wealth Inequality
Authors: Applegate J. M. , Janssen Marco A.
Published: October 2020

The extent to which employees change jobs, known as the job mobility rate, has been steadily declining in the US for decades. This decline is understood to have a negative impact on both productivity and wages, and econometric studies fail to support any single cause brought forward. This decline coincides with decreases in household savings, increases in household debt and wage stagnation. We propose that the decline could be the consequence of a complex interaction between mobility, savings, wages and debt, such that if changing jobs incurs costs which are paid out of savings, or incurs debt in the absence of sufficient savings, a negative feedback loop is generated. People are further restricted in making moves by their debt obligations and inability to save, which in turn depresses wages further. To explore this hypothesis, we developed a stylized model in which agents chose their employment situation based on their opportunities and preferences for work and where there are costs to changing jobs and the possibility of borrowing to meet those costs. We indeed found evidence of a negative feedback loop involving changes, wages, savings and debt, as well as evidence that this dynamic results in a level of wealth inequality on the same scale as we see today in the US.
Burnstock and the legacy of the inhibitory junction potential and P2Y1 receptors
Authors: King Brian F.
Published: October 2020

The synaptic event called the inhibitory junction potential (IJP) was arguably one of the more important discoveries made by Burnstock and arguably one of his finer legacies. The discovery of the IJP fundamentally changed how electromechanical coupling was visualised in gastrointestinal smooth muscle. Its discovery also set in motion the search for novel inhibitory neurotransmitters in the enteric nervous system, eventually leading to proposal that ATP or a related nucleotide was a major inhibitory transmitter. The subsequent development of purinergic signalling gave impetus to expanding the classification of surface receptors for extracellular ATP, not only in the GI tract but beyond, and then led to successive phases of medicinal chemistry as the P2 receptor field developed. Ultimately, the discovery of the IJP led to the successful cloning of the first P2Y receptor (chick P2Y1) and expansion of mammalian ATP receptors into two classes: metabotropic P2Y receptors (encompassing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11–14 receptors) and ionotropic P2X receptors (encompassing homomeric P2X1–P2X7 receptors). Here, the causal relationship between the IJP and P2Y1 is explored, setting out the milestones reached and achievements made by Burnstock and his colleagues.
PDERL: an accurate and fast algorithm with a novel perspective on solving the old viewshed analysis problem
Authors: Wu Chuanjun , Guan Lingxiao , Xia Qing , Chen Gang , Shen Baohong
Published: October 2020

Viewshed analysis based on the regular grid digital elevation model (DEM) is one of the basic functions of geographic information systems. Traditional viewshed analysis algorithms are mainly carried out in a geospatial coordinate system, that create complexities when it is necessary to accurately express a perspective relationship. Moreover, it can only reduce the amount of calculation by using approximation methods, which result in decreased accuracy. We found that the error ratio of approximation algorithms is low but uneven and thereby highly likely to result in continuous area visibility errors. Despite the quality of DEM data having improved significantly in the last decade, traditional approximation algorithms have been unable to take full advantage of the improved data. Finding a fast and accurate algorithm has therefore become an urgent task. This study takes a new perspective to solve this problem by establishing a ‘proximity-direction-elevation’ (PDE) coordinate system and proposing a PDE spatial reference line (PDERL) algorithm within it. Many experiments prove that the accuracy of PDERL is the same as the R3 algorithm and its speed is about half that of the XDraw and reference plane algorithms, but much faster than R3. Due to the speed of PDERL, it is now possible and practical to do an accurate large-area DEM-based viewshed analysis.
Anti-phage serum antibody responses and the outcome of phage therapy
Authors: Łusiak-Szelachowska M. , Międzybrodzki R. , Fortuna W. , Borysowski J. , Górski Andrzej
Published: October 2020

We examined the appearance of serum anti-phage antibodies in 25 patients with chronic sinusitis treated with phage therapy (PT). Approximately 30% of patients with weak antibody responses responded positively to PT, which was similar to the results of treatment achieved in a group of patients with high antibody production. In addition, there was no correlation between antibody level and the outcome of PT. These data, derived from a homogenous group of patients, confirm our earlier findings suggesting that the prognostic significance of serum anti-phage antibodies for the outcome of PT should be determined by relevant clinical trials.
The protection of minor athletes in sports investigation proceedings
Authors: Hessert Björn
Published: October 2020

Sports associations have an interest in the maintenance of a level playing field among all participants. Athletes are therefore bound by the same sporting rules. This also applies to minor athletes who compete at the highest level of their sport. The disciplinary autonomy of sports governing bodies enables them to initiate sports investigations against minor athletes alleged of being in violation of sports regulations, including those pertaining to doping and match manipulation. During the investigations, minor athletes may be obliged to attend sports interrogations or grant full access to diverse of personal information and documentary evidence, including mobile phones, emails, SMS and WhatsApp conversations, and health records. However, the vulnerability of young athletes requires sufficient protection of minors and safeguards in sports investigation proceedings. The aim of this article is to examine the legality of internal sports investigation proceedings against minors in respect to doping and manipulation of sports competition matters. In particular, it analyses whether it is legitimate and reasonable to use investigative measures contained in the regulations of sports governing bodies against minor athletes in the light of the principle of proportionality.
Aktueller Stand der Hypophysenchirurgie
Authors: Micko Alexander , Wolfsberger Stefan , Vila Greisa , Höftberger Romana , Luger Anton , Knosp Engelbert
Published: October 2020

Eine gut funktionierende Kooperation zwischen Neurochirurgie und Endokrinologie sowie die enge Zusammenarbeit mit Neuropathologie, Neuroradiologie und Neuroophthalmologie sind die Voraussetzungen für eine erfolgreiche Behandlung von Hypophysenadenomen. Hypophysenadenome können heute durch den technologischen Fortschritt immer sicherer und komplikationsärmer operiert werden. Dazu gehört neben einer High-Tech-Ausrüstung auch eine spezielle histologische bzw. molekulare Aufarbeitung des Tumorgewebes, um eine optimale multimodale Therapie anbieten zu können. Um ausgedehnte, invasive und aggressiv wachsende Hypophysenadenome, die ein interdisziplinäres Vorgehen benötigen, behandeln zu können, ist es heutzutage notwendig, dies in spezialisierten Zentren durchzuführen.
Perceptions, attitudes and training needs of primary healthcare professionals in identifying and managing frailty: a qualitative study
Authors: Avgerinou Christina , Kotsani Marina , Gavana Magda , Andreou Martha , Papageorgiou Dimitra-Iosifina , Roka Violeta , Symintiridou Despoina , Manolaki Chrysanthi , Soulis George , Smyrnakis Emmanouil
Published: October 2020

Purpose

Although frailty can be delayed or prevented by appropriate interventions, these are often not available in countries lacking formal education and infrastructure in geriatrics. The aim of this study was to: (a) explore ideas, perceptions and attitudes of primary health care (PHC) professionals towards frailty in a country where geriatrics is not recognised as a specialty; (b) explore PHC professionals’ training needs in frailty; and (c) define components of a frailty educational programme in PHC.

Methods

Qualitative design, using two focus groups with PHC professionals conducted in Thessaloniki, Greece. Focus groups were audio recorded and transcribed. Data were analysed with thematic analysis.

Results

In total 31 PHC professionals (mean age: 46 years; gender distribution: 27 females, 4 males) participated in the study (physicians n = 17; nurses n = 12; health visitors n = 2). Four main themes were identified: (1) Perceptions and understanding of frailty; (2) Facilitators and barriers to frailty identification and management; (3) Motivation to participate in a frailty training programme; (4) Education and training. The main barriers for the identification and management of frailty were associated with the healthcare system, including duration of appointments, a focus on prescribing, and problems with staffing of allied health professionals, but also a lack of education. Training opportunities were scarce and entirely based on personal incentive. Professionals were receptive to training either face-to-face or online. A focus on learning practical skills was key.

Conclusion

Education and training of professionals and interdisciplinary collaboration are essential and much needed for the delivery of person-centred care for people with frailty living in the community.
Progress through Regression
Authors: Biddle Jeff E.
Published: October 2020

The Cobb-Douglas regression, a statistical technique developed to estimate what economists called a 'production function', was introduced in the late 1920s. For several years, only economist Paul Douglas and a few collaborators used the technique, while vigorously defending it against numerous critics. By the 1950s, however, several economists beyond Douglas's circle were using the technique, and by the 1970s, Douglas's regression, and more sophisticated procedures inspired by it, had become standard parts of the empirical economist's toolkit. This volume is the story of the Cobb-Douglas regression from its introduction to its acceptance as general-purpose research tool. The story intersects with the histories of several important empirical research programs in twentieth century economics, and vividly portrays the challenges of empirical economic research during that era. Fundamentally, this work represents a case study of how a controversial, innovative research tool comes to be widely accepted by a community of scholars.
War and Citizenship
Authors: Caglioti Daniela L.
Published: October 2020

What did it mean to be an alien, and in particular an enemy alien, in the interstate conflicts that occurred over the nineteenth century and that climaxed in the First World War? In this ambitious and broad-ranging study, Daniela L. Caglioti highlights the many ways in which belligerent countries throughout the world mobilized populations along the member/non-member divide, redefined inclusion and exclusion, and refashioned notions and practices of citizenship. She examines what it meant to be an alien in wartime, how the treatment of aliens in wartime interfered with sovereignty and the rule of law, and how that treatment affected population policies, individual and human rights, and conceptions of belonging. Concentrating on the gulf between citizens and foreigners and on the dilemma of balancing rights and security in wartime, Caglioti highlights how each country, regardless of its political system, chose national security even if this meant reducing freedom, discriminating among citizens and non-citizens, and violating international law.
The Victorian Cult of Shakespeare
Authors: LaPorte Charles
Published: October 2020

In the Victorian era, William Shakespeare's work was often celebrated as a sacred text: a sort of secular English Bible. Even today, Shakespeare remains a uniquely important literary figure. Yet Victorian criticism took on religious dimensions that now seem outlandish in retrospect. Ministers wrote sermons based upon Shakespearean texts and delivered them from pulpits in Christian churches. Some scholars crafted devotional volumes to compare his texts directly with the Bible's. Still others created Shakespearean societies in the faith that his inspiration was not like that of other playwrights. Charles LaPorte uses such examples from the Victorian cult of Shakespeare to illustrate the complex relationship between religion, literature and secularization. His work helps to illuminate a curious but crucial chapter in the history of modern literary studies in the West, as well as its connections with Biblical scholarship and textual criticism.
The Ethics of Social Punishment
Authors: Radzik Linda , Bennett Christopher , Pettigrove Glen , Sher George
Published: October 2020

How do we punish others socially, and should we do so? In her 2018 Descartes Lectures for Tilburg University, Linda Radzik explores the informal methods ordinary people use to enforce moral norms, such as telling people off, boycotting businesses, and publicly shaming wrongdoers on social media. Over three lectures, Radzik develops an account of what social punishment is, why it is sometimes permissible, and when it must be withheld. She argues that the proper aim of social punishment is to put moral pressure on wrongdoers to make amends. Yet the permissibility of applying such pressure turns on the tension between individual desert and social good, as well as the possession of an authority to punish. Responses from Christopher Bennett, George Sher and Glen Pettigrove challenge Radzik's account of social punishment while also offering alternative perspectives on the possible meanings of our responses to wrongdoing. Radzik replies in the closing essay.
Authoritarian Police in Democracy
Authors: González Yanilda María
Published: October 2020

In countries around the world, from the United States to the Philippines to Chile, police forces are at the center of social unrest and debates about democracy and rule of law. This book examines the persistence of authoritarian policing in Latin America to explain why police violence and malfeasance remain pervasive decades after democratization. It also examines the conditions under which reform can occur. Drawing on rich comparative analysis and evidence from Brazil, Argentina, and Colombia, the book opens up the 'black box' of police bureaucracies to show how police forces exert power and cultivate relationships with politicians, as well as how social inequality impedes change. González shows that authoritarian policing persists not in spite of democracy but in part because of democratic processes and public demand. When societal preferences over the distribution of security and coercion are fragmented along existing social cleavages, politicians possess few incentives to enact reform.
Finitely many physical measures for sectional-hyperbolic attracting sets and statistical stability
Authors: ARAUJO VITOR
Published: October 2020

We show that a sectional-hyperbolic attracting set for a Hölder-
$C^{1}$
vector field admits finitely many physical/SRB measures whose ergodic basins cover Lebesgue almost all points of the basin of topological attraction. In addition, these physical measures depend continuously on the flow in the

$C^{1}$
topology, that is, sectional-hyperbolic attracting sets are statistically stable. To prove these results we show that each central-unstable disk in a neighborhood of this class of attracting sets is eventually expanded to contain a ball whose inner radius is uniformly bounded away from zero.
CUPPING AND JUMP CLASSES IN THE COMPUTABLY ENUMERABLE DEGREES
Authors: GREENBERG NOAM , MENG NG KENG , WU GUOHUA
Published: October 2020

We show that there is a cuppable c.e. degree, all of whose cupping partners are high. In particular, not all cuppable degrees are${\operatorname {\mathrm {low}}}_3$-cuppable, or indeed${\operatorname {\mathrm {low}}}_n$cuppable for anyn, refuting a conjecture by Li. On the other hand, we show that one cannot improve highness to superhighness. We also show that the${\operatorname {\mathrm {low}}}_2$-cuppable degrees coincide with the array computable-cuppable degrees, giving a full understanding of the latter class.
INQUISITIVE BISIMULATION
Authors: CIARDELLI IVANO , OTTO MARTIN
Published: October 2020

Inquisitive modal logic, InqML, is a generalisation of standard Kripke-style modal logic. In its epistemic incarnation, it extends standard epistemic logic to capture not just the information that agents have, but also the questions that they are interested in. Technically, InqML fits within the family of logics based on team semantics. From a model-theoretic perspective, it takes us a step in the direction of monadic second-order logic, as inquisitive modal operators involve quantification over sets of worlds. We introduce and investigate the natural notion of bisimulation equivalence in the setting of InqML. We compare the expressiveness of InqML and first-order logic in the context of relational structures with two sorts, one for worlds and one for information states, and characterise inquisitive modal logic as the bisimulation invariant fragment of first-order logic over various natural classes of two-sorted structures.
Comparison between mirror Langmuir probe and gas-puff imaging measurements of intermittent fluctuations in the Alcator C-Mod scrape-off layer
Authors: Kube R. , Theodorsen A. , Garcia O. E. , Brunner D. , LaBombard B. , Terry J. L.
Published: October 2020

Statistical properties of the scrape-off layer plasma fluctuations are studied in ohmically heated plasmas in the Alcator C-Mod tokamak. For the first time, plasma fluctuations as well as parameters that describe the fluctuations are compared across measurements from a mirror Langmuir probe (MLP) and from gas-puff imaging (GPI) that sample the same plasma discharge. This comparison is complemented by an analysis of line emission time-series data, synthesized from the MLP electron density and temperature measurements. The fluctuations observed by the MLP and GPI typically display relative fluctuation amplitudes of order unity together with positively skewed and flattened probability density functions. Such data time series are well described by an established stochastic framework that models the data as a superposition of uncorrelated, two-sided exponential pulses. The most important parameter of the process is the intermittency parameter,

$\gamma = {\tau _{d}} / {\tau _{w}}$

, where

${\tau _{d}}$

denotes the duration time of a single pulse and

${\tau _{w}}$

gives the average waiting time between consecutive pulses. Here we show, using a new deconvolution method, that these parameters can be consistently estimated from different statistics of the data. We also show that the statistical properties of the data sampled by the MLP and GPI diagnostic are very similar. Finally, a synthetic GPI signal using only plasma parameters sampled by the MLP shows qualitatively different fluctuation statistics from the measured GPI signal.
Local dynamic spontaneous brain activity changes in first-episode, treatment-naïve patients with major depressive disorder and their associated gene expression profiles
Authors: Xue Kaizhong , Liang Sixiang , Yang Bingbing , Zhu Dan , Xie Yingying , Qin Wen , Liu Feng , Zhang Yong , Yu Chunshui
Published: October 2020

Background

Major depressive disorder (MDD) is a common debilitating disorder characterized by impaired spontaneous brain activity, yet little is known about its alterations in dynamic properties and the molecular mechanisms associated with these changes.

Methods

Based on the resting-state functional MRI data of 65 first-episode, treatment-naïve patients with MDD and 66 healthy controls, we compared dynamic regional homogeneity (dReHo) of spontaneous brain activity between the two groups, and we investigated gene expression profiles associated with dReHo alterations in MDD by leveraging transcriptional data from the Allen Human Brain Atlas and weighted gene co-expression network analysis.

Results

Compared with healthy controls, patients with MDD consistently showed reduced dReHo in both fusiform gyri and in the right temporal pole and hippocampus. The expression profiles of 16 gene modules were correlated with dReHo alterations in MDD. These gene modules were enriched for various biological process terms, including immune, synaptic signalling, ion channels, mitochondrial function and protein metabolism, and were preferentially expressed in different cell types.

Conclusions

Patients with MDD have reduced dReHo in brain areas associated with emotional and cognitive regulation, and these changes may be related to complex polygenetic and polypathway mechanisms.
Current and future nonstimulants in the treatment of pediatric ADHD: monoamine reuptake inhibitors, receptor modulators, and multimodal agents
Authors: Cutler Andrew J. , Mattingly Gregory W. , Jain Rakesh , O’Neal Welton
Published: October 2020

Attention-deficit/hyperactivity disorder (ADHD), the single most common neuropsychiatric disorder with cognitive and behavioral manifestations, often starts in childhood and usually persists into adolescence and adulthood. Rarely seen alone, ADHD is most commonly complicated by other neuropsychiatric disorders that must be factored into any intervention plan to optimally address ADHD symptoms. With more than 30 classical Schedule II (CII) stimulant preparations available for ADHD treatment, only three nonstimulants (atomoxetine and extended-release formulations of clonidine and guanfacine) have been approved by the United States Food and Drug Administration (FDA), all of which focus on modulating the noradrenergic system. Given the heterogeneity and complex nature of ADHD in most patients, research efforts are identifying nonstimulants which modulate pathways beyond the noradrenergic system. New ADHD medications in clinical development include monoamine reuptake inhibitors, monoamine receptor modulators, and multimodal agents that combine receptor agonist/antagonist activity (receptor modulation) and monoamine transporter inhibition. Each of these “pipeline” ADHD medications has a unique chemical structure and differs in its pharmacologic profile in terms of molecular targets and mechanisms. The clinical role for each of these agents will need to be explored with regard to their potential to address the heterogeneity of individuals struggling with ADHD and ADHD-associated comorbidities. This review profiles alternatives to Schedule II (CII) stimulants that are in clinical stages of development (Phase 2 or 3). Particular attention is given to viloxazine extended-release, which has completed Phase 3 studies in children and adolescents with ADHD.
Dyson swarms of von Neumann probes: prospects and predictions
Authors: Haliki Emir
Published: October 2020

According to the Kardashev scale, possible Type-II and above civilizations could use energy sources of the universe in different ways. Self-replicator von Neumann probes believed to invade any galaxies in various studies could also have uses for gaining energy, in which Dyson swarm structures are likely to consist of probes that could emit energy from any luminous celestial object is to be considered first. On addressing some possible dynamical properties of probes, the study has examined in which size and populations they could enfold a star and how they could have observational evidences according to relevant star's energy output. On the basis of our solar system, it has also been shown using a weighted-directed network structure what kind of population and route they could have in case of spreading to the nearest-neighbouring stars.
Employer Engagement in Promoting the Labour-Market Participation of Jobseekers with Disabilities. An Employer Perspective
Authors: van Berkel Rik
Published: October 2020

This article contributes to the literature on engaging employers in activation policies. It focuses on a specific policy aimed at promoting the labour-market participation of people with disabilities. Unlike many activation policies, this policy recognises that the engagement of employers and the human resource management practices in their organisations are crucial factors for the policy’s success. The article reports on a study among employers participating in this policy. It focuses on the challenges employers experience in placing people with disabilities in their organisations, and on the public support they expect in dealing with these challenges. The article concludes that as promoting the labour-market participation of groups remote from the labour market requires social policy interventions as well as interventions in organisational human resource management, it poses challenges for policy makers, agencies providing employment services, and employers and their organisations.
Voluntary Stopping of Eating and Drinking in Swiss Outpatient Care
Authors: Stängle Sabrina , Schnepp Wilfried , Büche Daniel , Fringer André
Published: October 2020

Abstract. Besides physician-assisted suicide, there is another end-of-life practice under discussion: voluntary stopping of eating and drinking (VSED). In this study, we assess the occurrence of VSED in outpatient care and evaluate nurses’ attitudes about it. We recruited 395 nurses (24% response rate) in our online survey. The occurrence of VSED in Switzerland lies at 0.5%. Most nurses (84.6%) were aware of VSED, and 39.5% had experienced it with patients. VSED was mostly (70.3%) regarded as a natural death, and nearly all (95.1%) were willing to care for these patients; however, about one-quarter (26.5%) expressed moral concerns. Our results show that VSED occurs in rare cases, and that nurses are willing to accompany patients during this VSED, but express moral concerns.
Instagram Use, InstaMums, and Anxiety in Mothers of Young	Children
Authors: Moujaes Mara , Verrier Diarmuid
Published: October 2020

Abstract. The emergence of social media has revolutionized communication and has had a profound effect on many aspects of motherhood. Image-centric social media, despite its overwhelming popularity, has faced much criticism for over-idealistic portrayals and the pressures it may place on women throughout pregnancy and the early years of their child’s life. This research aimed to determine whether a significant relationship exists between postnatal anxiety and Instagram usage in mothers with young children. The associational, cross-sectional design uses a sample of 210 mothers, aged 22–45, who have one or more children aged under 5 years. An online questionnaire measured anxiety, Instagram usage, and several potentially moderating traits. We found that the relationship between anxiety and online engagement with InstaMums – mothers made famous by Instagram – was moderated by both social comparison orientation and self-esteem. Engagement with InstaMums was associated with greater anxiety in those with higher social comparison orientation; it was also associated with greater anxiety in those with lower self-esteem. These findings are discussed in connection with social comparison theory, implications for healthy social media use, as well as avenues for future research.
Seasonal to Decadal Predictions With MIROC6: Description and Basic Evaluation
Authors: Kataoka Takahito , Tatebe Hiroaki , Koyama Hiroshi , Mochizuki Takashi , Ogochi Koji , Naoe Hiroaki , Imada Yukiko , Shiogama Hideo , Kimoto Masahide , Watanabe Masahiro
Published: October 2020

The present paper presents results of seasonal‐to‐decadal climate predictions based on a coupled climate model called the Model for Interdisciplinary Research on Climate version 6 (MIROC6) contributing to the Coupled Model Intercomparison Project Phase 6 (CMIP6). MIROC6 is initialized every year for 1960–2018 by assimilating observed ocean temperature and salinity anomalies and full fields of sea ice concentration and by prescribing atmospheric initial states from reanalysis data. The impacts of updating the system on prediction skill are then evaluated by comparing hindcast experiments between the MIROC6 prediction system and a previous system based on MIROC version 5 (MIROC5). Skill of seasonal prediction is overall improved in association with representation and initialization of El Niño/Southern Oscillation (ENSO), the Quasi‐Biennial Oscillation (QBO), and the Northern Hemisphere sea ice concentration in MIROC6. In particular, the QBO is skillfully predicted up to 3 years ahead with a maximum anomaly correlation exceeding r = 0.8. The prediction skill for the North Atlantic Oscillation in winter is also enhanced, but the prediction still suffers from model's inherent errors. On decadal timescales, MIROC6 has a larger fraction of areas of the globe with better surface temperature skill at all lead times than MIROC5, and it has predictive skill in the annual‐mean sea surface temperature (SST) in the North Atlantic and the Pacific. In particular, MIROC6 hindcasts at 2–5 years lead time are able to capture the spatial structure of SST changes in the North Pacific and the eastern tropical Pacific associated with the 1970s regime shift better than MIROC5 hindcasts.
Linking Hydrology and Dissolved Organic Matter Characteristics in a Subtropical Wetland: A Long‐Term Study of the Florida Everglades
Authors: Regier Peter , Larsen Laurel , Cawley Kaelin , Jaffé Rudolf
Published: October 2020

Dissolved organic matter (DOM) acts as an important biogeochemical component of aquatic ecosystems that controls nutrient cycling, influences water quality, and links terrestrial and oceanic carbon pools, yet long‐term studies of how changing environmental drivers alter its abundance and composition are rare. Using a 10‐year, spatially explicit data set from Everglades National Park, a globally significant wetland, we investigated the relationships between DOM quality/quantity and hydrologic/climatic drivers along two contrasting marsh‐estuarine transects based on generalized linear modeling and a cumulative sums analysis. Analyses revealed distinct spatial, seasonal, and interannual patterns in variability of DOC and optical properties. Landscape‐scale seasonal patterns showed an enrichment in microbial‐like and protein‐like DOM during the dry season relative to the wet season. While some compositional constituents varied with the solar calendar, responsive to temperature and photoperiod, others varied with the hydrologic calendar. Independent water level and discharge effects indicated strong hydrologic control on DOM quality that differed between the two transects, evidencing differences in their connectivity to areas of high agricultural activity. Across all sites, a significant long‐term increasing trend in the fluorescence index was observed, associated with a positive correlation with precipitation and also potential changes in agricultural inputs, with other features associated with drought and hurricanes. Lastly, the cumulative sums analysis revealed differences between the two transects in the sensitivity of DOM composition to decreased water levels associated with 30‐year climate scenarios, with the less hydrologically dynamic transect exhibiting greater potential sensitivity.
MAVEN SEP Observations of Scorpius X‐1 X‐Rays at Mars: A Midatmosphere Occultation Analysis Technique
Authors: Rahmati A. , Larson D. E. , Cravens T. E. , Lillis R. J. , Lee C. O. , Dunn P. A.
Published: October 2020

We report on the first observations of atmospheric occultations at Mars of ~10 keV X‐rays from an extrasolar source identified as Scorpius X‐1. The measurements are taken by the SEP (Solar Energetic Particle) instrument on the MAVEN (Mars Atmosphere and Volatile EvolutioN) spacecraft. The detected X‐ray photons from Scorpius X‐1 penetrate the Martian atmosphere down to ~70 km altitude, before being attenuated by the neutrals in the atmosphere. The occultation altitude varies by a few km depending on the source X‐ray energy and the atmospheric neutral density. In this work, we study the detection response of SEP to Scorpius X‐1 X‐rays and demonstrate that X‐ray occultation data can be used in conjunction with a model of the light extinction curve in order to gain insights into the neutral density of the Mars atmosphere in the 50–100 km altitude range, an important and largely unexplored altitude range at Mars.
Effect of Pressure Rate on Rate and State Frictional Slip
Authors: Rudnicki J. W. , Zhan Y.
Published: October 2020

This paper analyzes the effects of pore pressure rate for a spring‐block system that is a simple model of a laboratory experiment. Pore pressure is increased at a constant rate in a remote reservoir, and slip is governed by rate and state friction. The frequency of rapid slip events increases with the increase of a nondimensional pressure rate that is the ratio of the time scale of frictional sliding to that for pressure increase. As the pressure rate increases, the more rapid increase of pore pressure on the slip surface quickly stabilizes slip events due to rate and state friction. Rate and state and pressure rate effects interact in a limited range of pressure rate and diffusivity. This range includes pressure rates and diffusivities representative of recent laboratory experiments.
Speleothems of South American and Asian Monsoons Influenced by a Green Sahara
Authors: Tabor Clay , Otto‐Bliesner Bette , Liu Zhengyu
Published: October 2020

The mid‐Holocene is frequently used for climate model‐proxy comparison studies, yet models often struggle to replicate the proxy signals from this period. Here, we use an Earth system model that tracks water isotopologies to determine the importance of a vegetated Sahara in the simulation of mid‐Holocene climate, with a focus on δ18O values recorded in speleothems from the South American and Asian monsoon regions. We find that inclusion of a vegetated Sahara during the mid‐Holocene leads to global warming and generally amplifies the changes in the δ18O values of the precipitation in the South American and Asian monsoon regions relative to preindustrial; both feedbacks improve model‐proxy agreement. Our results highlight the importance of regional vegetation alteration for accurate simulation of past climate, even when the region of study is far from the source of vegetation change.
Pitch‐Angle Scattering of Inner Magnetospheric Electrons Caused by ECH Waves Obtained With the Arase Satellite
Authors: Fukizawa M. , Sakanoi T. , Miyoshi Y. , Kazama Y. , Katoh Y. , Kasahara Y. , Matsuda S. , Matsuoka A. , Kurita S. , Shoji M. , Teramoto M. , Imajo S. , Sinohara I. , Wang S.‐Y. , Tam S. W.‐Y. , Chang T.‐F. , Wang B.‐J. , Jun C.‐W.
Published: October 2020

Electrostatic electron cyclotron harmonic (ECH) waves are generally excited in the magnetic equator region, in the sector from nightside to dayside during geomagnetically active conditions, and cause the pitch angle scattering by cyclotron resonance. The scattered electrons precipitate into the Earth's atmosphere and cause auroral emission. However, there is no observational evidence that ECH waves actually scatter electrons into the loss cone in the magnetosphere. In this study, from simultaneous wave and particle observation data obtained by the Arase satellite equipped with a high‐pitch angular resolution electron analyzer, we present evidence that the ECH wave intensity near the magnetic equator is correlated with an electron flux inside the loss cone with an energy of about 5 keV. The simulation suggests that this electron flux contributes to the auroral emission at 557.7 nm with an intensity of about 200 R.
Impact of Climate Change on Surface Stirring and Transport in the Mediterranean Sea
Authors: Ser‐Giacomi Enrico , Jordá‐Sánchez Gabriel , Soto‐Navarro Javier , Thomsen Sören , Mignot Juliette , Sevault Florence , Rossi Vincent
Published: October 2020

Understanding how climate change will affect oceanic fluid transport is crucial for environmental applications and human activities. However, a synoptic characterization of the influence of climate change on mesoscale stirring and transport in the surface ocean is missing. To bridge this gap, we exploit a high‐resolution, fully coupled climate model of the Mediterranean basin using a Network Theory approach. We project significant increases of horizontal stirring and kinetic energies in the next century, likely due to increments of available potential energy. The future evolution of basin‐scale transport patterns hints at a rearrangement of the main hydrodynamic provinces, defined as regions of the surface ocean that are well mixed internally but with minimal cross‐flow across their boundaries. This results in increased heterogeneity of province sizes and stronger mixing in their interiors. Our approach can be readily applied to other oceanic regions, providing information for the present and future marine spatial planning.
Daily Cropland Soil NOx Emissions Identified by TROPOMI and SMAP
Authors: Huber Daniel E. , Steiner Allison L. , Kort Eric A.
Published: October 2020

We use TROPOMI (TROPOspheric Monitoring Instrument) tropospheric nitrogen dioxide (NO2) measurements to identify cropland soil nitrogen oxide (NOx = NO + NO2) emissions at daily to seasonal scales in the U.S. Southern Mississippi River Valley. Evaluating 1.5 years of TROPOMI observations with a box model, we observe seasonality in local NOx enhancements and estimate maximum cropland soil NOx emissions (15–34 ng N m−2 s−1) early in growing season (May–June). We observe soil NOx pulsing in response to daily decreases in volumetric soil moisture (VSM) as measured by the Soil Moisture Active Passive (SMAP) satellite. Daily NO2 enhancements reach up to 0.8 × 1015 molecules cm−2 4–8 days after precipitation when VSM decreases to ~30%, reflecting emissions behavior distinct from previously defined soil NOx pulse events. This demonstrates that TROPOMI NO2 observations, combined with observations of underlying process controls (e.g., soil moisture), can constrain soil NOx processes from space.
Attenuated Interannual Variability of Austral Winter Antarctic Sea Ice Over Recent Decades
Authors: Li Shujun , Cai Wenju , Wu Lixin
Published: October 2020

Changes in Antarctic sea ice modify surface circulation, deep‐water formation, and overturning circulation, affecting the ecosystem and the atmosphere‐ocean‐ice interaction. Recent studies focused on long‐term trends of Antarctic sea ice, but whether its variability has changed is less clear. By examining reanalysis data sets, we show an interdecadal attenuation in variability of austral winter Antarctic sea ice since the late 1990s. This mainly arises from declined surface pressure variations in response to a combined effect of El Niño‐Southern Oscillation (ENSO) and the Southern Annular Mode (SAM). Compared to the pre‐1999 period, ENSO and the SAM have reduced variability in the post‐1999 period, and the linkage between them and Antarctic climate has weakened. The decreased level of variability over the 1999–2017 period may facilitate a more sensitive response of Antarctic sea ice to an external forcing, by enhancing the signal‐to‐noise ratio.
Segmentation of the Aleutian‐Alaska Subduction Zone Revealed by Full‐Wave Ambient Noise Tomography: Implications for the Along‐Strike Variation of Volcanism
Authors: Yang Xiaotao , Gao Haiying
Published: October 2020

The along‐strike variations of the velocity, thickness, and dip of subducting slabs and the volcano distribution have been observed globally. It is, however, unclear what controls the distribution of volcanoes and the associated magma generation. With the presence of nonuniform volcanism, the Aleutian‐Alaska subduction zone (AASZ) is an ideal place to investigate subduction segmentation and its relationship with volcanism. Using full‐wave ambient noise tomography, we present a high‐resolution 3‐D shear wave velocity model of the AASZ for the depths of 15–110 km. The velocity model reveals the distinct high‐velocity Pacific slab, the thicker, flatter, and more heterogeneous Yakutat slab, and the northeasterly dipping Wrangell slab. We observe low velocities within the uppermost mantle (at depth <60 km) below the Aleutian arc volcanoes, representing partial melt accumulation. The large crustal low‐velocity anomaly beneath the Wrangell volcanic field suggests a large magma reservoir, likely responsible for the clustering of volcanoes. The Denali volcanic gap is above an average‐velocity crust but an extremely fast mantle wedge, suggesting the lack of subsurface melt. This is in contrast with the lower‐velocity back‐arc mantle beneath the adjacent Buzzard Creek‐Jumbo Dome volcanoes to the east. The back‐arc low velocities associated with the Pacific, the eastern Yakutat, and the Wrangell slabs may reflect subduction‐driven mantle upwelling. The structural variation of the downgoing slabs and the overriding plate explains the change of volcanic activity along the AASZ. Our findings demonstrate the combined role of the subducting slab and the overriding plate in controlling the characteristics of arc magmatism.