bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis
Authors: Xu Chen , Bi Siyuan , Zhang Wenxin , Luo Lin
Published: July 2024

Background

This study aimed to evaluate the effects of creatine monohydrate supplementation on cognitive function in adults and explore its potential role in preventing and delaying cognitive impairment-related diseases.

Methods

Following the PRISMA 2020 guidelines, a systematic review with meta-analysis was conducted. Randomized controlled trials (RCTs) published between 1993 and 2024 were retrieved from PubMed, Scopus, and Web of Science databases. The study protocol was registered with PROSPERO (registration number: CRD42024533557). The impact of creatine supplementation on overall cognitive function, memory, executive function, attention, and information processing speed was assessed using standardized mean differences (SMD) and Hedge’s g with 95% confidence intervals (CI).

Results

Sixteen RCTs involving 492 participants aged 20.8–76.4 years, including healthy individuals and patients with specific diseases, were selected. Creatine monohydrate was the form used in all included studies. Creatine supplementation showed significant positive effects on memory (SMD = 0.31, 95% CI: 0.18–0.44, Hedges’s g = 0.3003, 95% CI: 0.1778–0.4228) and attention time (SMD = −0.31, 95% CI: −0.58 to −0.03, Hedges’s g = −0.3004, 95% CI: −0.5719 to −0.0289), as well as significantly improving processing speed time (SMD = −0.51, 95% CI: −1.01 to −0.01, Hedges’s g = −0.4916, 95% CI: −0.7852 to −0.1980). However, no significant improvements were found on overall cognitive function or executive function. Subgroup analyses revealed that creatine supplementation was more beneficial in individuals with diseases, those aged 18–60 years, and females. No significant differences were found between short- (<4 weeks) and long-term (≥4 weeks) interventions for improving cognitive function. Low-to-moderate risk of bias was found, and no significant publication bias was detected. The GRADE assessment indicates that the certainty of evidence for memory function is moderate, suggesting a reasonable level of confidence in the positive effects of creatine on memory. However, the evidence for processing speed, overall cognitive function, executive function, and attention is of low certainty, indicating that further research is needed to confirm these potential benefits.

Conclusion

Current evidence suggests that creatine monohydrate supplementation may confer beneficial effects on cognitive function in adults, particularly in the domains of memory, attention time, and information processing speed. Larger robust clinical trials are warranted to further validate these findings. Furthermore, future research should investigate the influence of different populations and intervention durations on the effects of creatine monohydrate supplementation, as well as elucidate the precise mechanisms underlying its potential cognitive-enhancing properties.
Juvenile dermatomyositis complications: navigating gastrointestinal perforations and treatment challenges, a case report
Authors: Xiangyuan Chen , Xiaoling Zeng , Guangchao Sun , Huasong Zeng , Dexin Liu
Published: July 2024

Juvenile dermatomyositis (JDM) is a rare autoimmune disorder with multi-system involvement, often presenting with a heliotrope rash, Gottron's papules, and proximal muscle weakness. JDM patients with anti-nuclear matrix protein 2 (anti-NXP2) positivity tend to have more severe manifestations, including a higher risk of gastrointestinal (GI) complications such as dysphagia, intestinal motility changes, edema, malabsorption, ulcers, and perforations. These complications are associated with poor outcomes and high mortality rates, particularly in patients with anti-NXP2 positivity. A case is presented of a 12-year-old girl with JDM who developed multiple GI perforations after being treated with high-dose methylprednisolone. Despite multiple surgical attempts, the patient experienced continued leakage and new perforations. The treatment approach was shifted to include jejunostomy, plasma exchanges, fresh frozen plasma support, and tofacitinib, leading to gradual improvement in muscle strength and reduction in inflammation. GI involvement in JDM is a significant concern due to its association with poor prognosis and high mortality. The use of high-dose glucocorticoids must be carefully considered in JDM patients with GI involvement, as they may contribute to the development of perforations and complicate treatment. A combination of plasma exchange, fresh frozen plasma support, low-dose glucocorticoids, and Janus kinase inhibitors may offer a safer treatment strategy for managing refractory JDM with GI complications. The case highlights the importance of a multidisciplinary approach to treatment and the need for further research to determine the necessity of high-dose glucocorticoid therapy following GI involvement in JDM.
The value of second-line anti-HER2 therapy in metastatic HER-2 positive patients: a cost-effectiveness analysis in China
Authors: Li Lu , Yang Shilei , Fang Fengqi , Tian Li , He Ying , Li Jia , Chen Yanwei , Dong Deshi
Published: July 2024

Background

Breast cancer (BC) is one of the most common cancers worldwide. The inevitability of drug resistance to initial anti-HER-2 therapy necessitates the emergence of second-line anti-HER-2 drugs which exhibit a promising outlook. Consequently, it is imperative to appraise their efficacy through network meta-analysis and ascertain their comparative cost-effectiveness.

Methods

The data used in our analysis were acquired from patients enrolled in the EMILIA, DESTINY-Breast03, and PHOEBE phase III randomized clinical trials. A partitioned survival model was used for patients diagnosed with HER-2-positive metastatic Breast cancer. The model was crafted with a time horizon of 10 years, operating on a 21-day cycle and incorporating a 5% discount rate for both costs and outcomes. The willingness-to-pay threshold was set at $36,058.06 per quality-adjusted life year (QALY). The impact of parameter uncertainty on the findings was assessed using a one-way deterministic sensitivity analysis and probability sensitivity analysis.

Findings

Within the model encompassing 1782 patients, the utilization of pyrotinib plus capecitabine (PC) treatment yielded an additional 0.70 QALY in comparison to T-DM1, resulting in an incremental cost-effectiveness ratio (ICER) of $31,121.53 per QALY gained. Similarly, the administration of T-DXd treatment led to an additional 0.80 QALY compared to T-DM1, resulting in an ICER of $153,950.19 per QALY gained. The PC strategies are considered more cost-effective than T-DM1 when the WTP threshold is set at $36,058.06 per QALY. However, this method is not cost effective for T-DXd. The probability of the PC strategies being cost-effective was 62%, whereas the probability of T-DXd was 0% when compared to T-DM1.

Conclusion

PC is a cost-effective therapy for patients afflicted with HER-2-positive metastatic BC compared to T-DM1 from the perspective of China at a WTP threshold of $36,058.06 per QALY. Nevertheless, T-DXd is not as cost-effective as T-DM1, considering its current medication pricing. Therefore, reducing the cost of T-DXd could improve its overall cost-effectiveness.
Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19
Authors: Silva-Santos Yasmin , Pagni Roberta Liberato , Gamon Thais Helena Martins , de Azevedo Marcela Santiago Pacheco , Bielavsky Mônica , Darido Maria Laura Goussain , de Oliveira Danielle Bruna Leal , de Souza Edmarcia Elisa , Wrenger Carsten , Durigon Edson Luiz , Luvizotto Maria Cecília Rui , Ackerman Hans Christian , Marinho Claudio Romero Farias , Epiphanio Sabrina , Carvalho Leonardo José Moura
Published: July 2024

COVID-19 causes more severe and frequently fatal disease in patients with pre-existing comorbidities such as hypertension and heart disease. SARS-CoV-2 virus enters host cells through the angiotensin-converting enzyme 2 (ACE2), which is fundamental in maintaining arterial pressure through the renin-angiotensin system (RAS). Hypertensive patients commonly use medications such as angiotensin-converting enzyme inhibitors (ACEi), which can modulate the expression of ACE2 and, therefore, potentially impact the susceptibility and severity of SARS-CoV-2 infection. Here we assessed whether treatment of ACE2-humanized (K18-hACE2) mice with the ACEi Lisinopril affects lung ACE2 levels and the outcome of experimental COVID-19. K18-hACE2 mice were treated for 21 days with Lisinopril 10 mg/kg and were then infected with 105 PFU of SARS-CoV-2 (Wuhan strain). Body weight, clinical score, respiratory function, survival, lung ACE2 levels, viral load, lung histology, and cytokine (IL-6, IL-33, and TNF-α) levels were assessed. Mice treated with Lisinopril for 21 days showed increased levels of ACE2 in the lungs. Infection with SARS-CoV-2 led to massive decrease in lung ACE2 levels at 3 days post-infection (dpi) in treated and untreated animals, but Lisinopril-treated mice showed a fast recovery (5dpi) of ACE2 levels. Higher ACE2 levels in Lisinopril-treated mice led to remarkably higher lung viral loads at 3 and 6/7dpi. Lisinopril-treated mice showed decreased levels of the pro-inflammatory cytokines IL-6 and TNF-α in the serum and lungs at 6/7dpi. Marginal improvements in body weight, clinical score and survival were observed in Lisinopril-treated mice. No differences between treated and untreated infected mice were observed in respiratory function and lung histology. Lisinopril treatment showed both deleterious (higher viral loads) and beneficial (anti-inflammatory and probably anti-constrictory and anti-coagulant) effects in experimental COVID-19. These effects seem to compensate each other, resulting in marginal beneficial effects in terms of outcome for Lisinopril-treated animals.
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Authors: Grether Uwe , Foxton Richard H. , Gruener Sabine , Korn Claudia , Kimbara Atsushi , Osterwald Anja , Zirwes Elisabeth , Uhles Sabine , Thoele Janina , Colé Nadine , Rogers-Evans Mark , Röver Stephan , Nettekoven Matthias , Martin Rainer E. , Adam Jean-Michel , Fingerle Jürgen , Bissantz Caterina , Guba Wolfgang , Alker André , Szczesniak Anna M. , Porter Ross F. , Toguri Tom J. , Revelant Franco , Poirier Agnès , Perret Camille , Winther Lotte , Caruso Antonello , Fezza Filomena , Maccarrone Mauro , Kelly Melanie E. M. , Fauser Sascha , Ullmer Christoph
Published: July 2024

Introduction

Preclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation has a therapeutic effect in animal models on chronic inflammation and vascular permeability, which are key pathological features of diabetic retinopathy (DR). A novel CB2R agonist, triazolopyrimidine RG7774, was generated through lead optimization of a high-throughput screening hit. The aim of this study was to characterize the pharmacology, absorption, distribution, metabolism, elimination, and toxicity (ADMET) profile of RG7774, and to explore its potential for managing the key pathological features associated with retinal disease in rodents.

Methods

The in vitro pharmacology of RG7774 was investigated for CB2R binding and receptor activation using recombinant human and mouse CB2R expression in Chinese hamster ovary cells, and endogenous CB2R expression in human Jurkat cells, and rat and mouse spleen cells. The ADMET profile was evaluated and the effects of RG7774 on retinal permeability, leukocyte adhesion, and choroidal neovascularization (CNV) were investigated in rodent models of retinal disease. Pharmacokinetic (PK) parameters and the exposure-response relationship were characterized in healthy animals and in animals with laser-induced CNV.

Results

RG7774 was found to be a potent (EC50: 2.8 nM and Ki: 51.3 nM), selective, and full CB2R agonist with no signs of cannabinoid receptor type 1 (CB1R) binding or activation. The ligand showed a favorable ADMET profile and exhibited systemic and ocular exposure after oral delivery. Functional potency in vitro translated from recombinant to endogenous expression systems. In vivo, orally administered RG7774 reduced retinal permeability and leukocyte adhesion in rodents with lipopolysaccharide (LPS)-induced uveitis and streptozotocin (STZ)-induced DR, and reduced lesion areas in rats with laser-induced CNV with an ED50 of 0.32 mg/kg. Anatomically, RG7774 reduced the migration of retinal microglia to retinal lesions.

Discussion

RG7774 is a novel, highly selective, and orally bioavailable CB2R agonist, with an acceptable systemic and ocular PK profile, and beneficial effects on retinal vascular permeability, leukocyte adhesion, and ocular inflammation in rodent animal models. Results support the development of RG7774 as a potential treatment for retinal diseases with similar pathophysiologies as addressed by the animal models.
Hyaluronic acid-modified liposomes Potentiated in-vivo anti-hepatocellular carcinoma of icaritin
Authors: Sun Xiaoduan , He Zhenzhen , Lu Ruilin , Liu Zhongbing , Chiampanichayakul Sawitree , Anuchapreeda Songyot , Jiang Jun , Tima Singkome , Zhong Zhirong
Published: July 2024

Introduction: Icaritin (ICT), a promising anti-hepatocellular carcinoma (HCC) prenylated flavonoid, is hindered from being applied due to its low water solubility and high lipophilicity in poorly differentiated HCC which is associated with upregulation of CD44 isoforms. Thus, hyaluronic acid (HA), a natural polysaccharide with high binding ability to CD44 receptors, was used to formulate a modified liposome as a novel targeted ICT-delivery system for HCC treatment.

Methods: The ICT-Liposomes (Lip-ICT) with and without HA were prepared by a combined method of thin-film dispersion and post-insertion. The particle size, polydispersity (PDI), zeta potential, encapsulation efficacy (%EE), drug loading content (%DLC), and in vitro drug release profiles were investigated for physicochemical properties, whereas MTT assay was used to assess cytotoxic effects on HCC cells, HepG2, and Huh7 cells. Tumor bearing nude mice were used to evaluate the inhibitory effect of HA-Lip-ICT and Lip-ICT in vivo.

Results: Lip-ICT and HA-Lip-ICT had an average particle size of 171.2 ± 1.2 nm and 208.0 ± 3.2 nm, with a zeta potential of −13.9 ± 0.83 and −24.8 ± 0.36, respectively. The PDI resulted from Lip-ICT and HA-Lip-ICT was 0.28 ± 0.02 and 0.26 ± 0.02, respectively. HA-Lip-ICT demonstrated higher in vitro drug release when pH was dropped from 7.4 to 5.5, The 12-h release rate of ICT from liposomes increased from 30% at pH7.4 to more than 60% at pH5.5. HA-Lip-ICT displayed higher toxicity than Lip-ICT in both HCC cells, especially Huh7with an IC50 of 34.15 ± 2.11 μM. The in vivo tissue distribution and anti-tumor experiments carried on tumor bearing nude mice indicated that HA-Lip- ICT exhibited higher tumor accumulation and achieved a tumor growth inhibition rate of 63.4%.

Discussion: The nano-sized Lip-ICT was able to prolong the drug release time and showed long-term killing HCC cells ability. Following conjugation with HA, HA-Lip-ICT exhibited higher cytotoxicity, stronger tumor targeting, and tumor suppression abilities than Lip-ICT attributed to HA-CD44 ligand-receptor interaction, increasing the potential of ICT to treat HCC.
Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens
Authors: Shi Yaning , Gao Zhixin , Xu Bing , Mao Junbing , Wang Yue , Liu Zongping , Wang Jicang
Published: July 2024

Cadmium (Cd) is a highly hazardous toxic substance that can cause serious harm to animals. Previous studies have indicated that cadmium chloride (CdCl2) can damage organs, such as the liver, ovaries, and testicles. Naringenin (Nar) represents a flavonoid with various properties that promote the alleviation of Cd-induced damage. In this experiment, 60 chickens were divided into the control group, 150 mg/kg CdCl2 treatment group, 250 mg/kg Nar treatment group, and 150 mg/kg CdCl2 + 250 mg/kg Nar co-treatment group, which were treated for 8 weeks. Kidney tissues samples were collected to investigate kidney function, including oxidative stress (OS), endoplasmic reticulum (ER) stress, and autophagy activity. Experimental results showed the decreased weight of chickens and increased relative weight of their kidneys after CdCl2 treatment. The increase in NAG, BUN, Cr, and UA activities, as well as the increase in MDA and GSH contents, and the decrease activities of T-AOC, SOD, and CAT in the kidney, manifested renal injury by OS in the chickens. TUNEL staining revealed that CdCl2 induced apoptosis in renal cells. CdCl2 upregulates the mRNA and protein expression levels of GRP78, PERK, eIF2α, ATF4, ATF6, CHOP, and LC3, and inhibited the mRNA and protein expression levels of P62 proteins, which leads to ER stress and autophagy. The CdCl2 + Nar co-treatment group exhibited alleviated CdCl2-induced kidney injury, OS, ER stress, and autophagy. Research has demonstrated that Nar reduces CdCl2-induced kidney injury through alleviation of OS, ER stress, and autophagy.
Anatomical location, sex, and age modulate adipocyte progenitor populations in perivascular adipose tissues
Authors: Rendon C. Javier , Sempere Lorenzo , Lauver Adam , Watts Stephanie W. , Contreras G. Andres
Published: July 2024

Perivascular adipose tissue (PVAT) regulates vascular function due to its capacity to synthesize vasoactive products and its mechanical properties. PVATs most abundant cells are adipocytes, and their populations are maintained by the maturation of adipocyte progenitor cells (APC), which may play a pivotal role in the pathogenesis of cardiovascular diseases. However, the distribution of APC within PVAT depots, their potential variation in spatial location, and the influence of sex and age on their abundance remain unknown. We hypothesize that APC abundance in PVAT is affected by location, age, sex and that APC subtypes have specific spatial distributions. PVAT from thoracic and abdominal aorta, and mesenteric arteries, and AT from interscapular, gonadal, and subcutaneous depots from 13-week and 30-week-old females and males Pdgfrα-CreERT2 x LSL-tdTomato mice (n = 28) were analyzed. Abdominal aorta PVAT had fewer progenitors than mesenteric PVAT and gonadal AT. Aging reduced the abundance of APC in the thoracic aorta but increased their numbers in mesenteric PVAT. Females had more APC than males in mesenteric PVAT and gonadal AT depots. APC exhibited unique spatial distribution in the aorta and mesenteric PVAT where they localized neighboring vasa vasorum and arteries. APC subtypes (APC1, APC2, APC3, diff APC) were identified in all PVAT depots. Thoracic aorta PVAT APC3 were located in the adventitia while diff APC were in the parenchyma. This study identified variability in APC populations based on depot, age, and sex. The distinctive spatial distribution and the presence of diverse APC subtypes suggest that they may contribute differently to cardiovascular diseases-induced PVAT remodeling.
Advanced integration of 2DCNN-GRU model for accurate identification of shockable life-threatening cardiac arrhythmias: a deep learning approach
Authors: Ba Mahel Abduljabbar S. , Cao Shenghong , Zhang Kaixuan , Chelloug Samia Allaoua , Alnashwan Rana , Muthanna Mohammed Saleh Ali
Published: July 2024

Cardiovascular diseases remain one of the main threats to human health, significantly affecting the quality and life expectancy. Effective and prompt recognition of these diseases is crucial. This research aims to develop an effective novel hybrid method for automatically detecting dangerous arrhythmias based on cardiac patients’ short electrocardiogram (ECG) fragments. This study suggests using a continuous wavelet transform (CWT) to convert ECG signals into images (scalograms) and examining the task of categorizing short 2-s segments of ECG signals into four groups of dangerous arrhythmias that are shockable, including ventricular flutter (C1), ventricular fibrillation (C2), ventricular tachycardia torsade de pointes (C3), and high-rate ventricular tachycardia (C4). We propose developing a novel hybrid neural network with a deep learning architecture to classify dangerous arrhythmias. This work utilizes actual electrocardiogram (ECG) data obtained from the PhysioNet database, alongside artificially generated ECG data produced by the Synthetic Minority Over-sampling Technique (SMOTE) approach, to address the issue of imbalanced class distribution for obtaining an accuracy-trained model. Experimental results demonstrate that the proposed approach achieves high accuracy, sensitivity, specificity, precision, and an F1-score of 97.75%, 97.75%, 99.25%, 97.75%, and 97.75%, respectively, in classifying all the four shockable classes of arrhythmias and are superior to traditional methods. Our work possesses significant clinical value in real-life scenarios since it has the potential to significantly enhance the diagnosis and treatment of life-threatening arrhythmias in individuals with cardiac disease. Furthermore, our model also has demonstrated adaptability and generality for two other datasets.
Genome-wide profile analysis of the Hsp20 family in lettuce and identification of its response to drought stress
Authors: Zhang Qinqin , Dai Bowen , Fan Mi , Yang Liling , Li Chang , Hou Guangguang , Wang Xiaofang , Gao Hongbo , Li Jingrui
Published: July 2024

Heat shock protein 20 (Hsp20) plays a very important role in response to abiotic stressors such as drought; however, in lettuce (Lactuca sativa L.), this gene family is poorly understood. This study used bioinformatics methods to identify 36 members of the lettuce Hsp20 family, which were named LsHsp20–1~LsHsp20–36. Subcellular localization results revealed that 26 members of the LsHsp20 protein family localized to the cytoplasm and nucleus. Additionally, 15 conserved domains were identified in the LsHsp20 protein family, with the number of amino acids ranging from 8 to 50. Gene structure analysis revealed that 15 genes (41.7%) had no introns, and 20 genes (55.5%) had one intron. The proportion of the LsHsp20 secondary structure was random coil > alpha helix > extended strand > beta turn. Chromosome positioning analysis indicated that 36 genes were unevenly distributed on nine chromosomes, and four pairs of genes were collinear. The Ka/Ks ratio of the collinear genes was less than 1, indicating that purifying selection dominated during L. sativa evolution. Thirteen pairs of genes were collinear in lettuce and Arabidopsis, and 14 pairs of genes were collinear in lettuce and tomato. A total of 36 LsHsp20 proteins were divided into 12 subgroups based on phylogenetic analysis. Three types of cis-acting elements, namely, abiotic and biotic stress-responsive, plant hormone-responsive, and plant development-related elements, were identified in the lettuce LsHsp20 family. qRT-PCR was used to analyze the expression levels of 23 LsHsp20 genes that were significantly upregulated on the 7th or 14th day of drought treatment, and the expression levels of two genes (LsHsp20–12 and LsHsp20–26) were significantly increased by 153-fold and 273-fold on the 14th and 7th days of drought treatment, respectively. The results of this study provide comprehensive information for research on the LsHsp20 gene family in lettuce and lay a solid foundation for further elucidation of Hsp20 biological functions, providing valuable information on the regulatory mechanisms of the LsHsp20 family in lettuce drought resistance.
When “I” or “S/He” uses the product: the impact of narrative perspective on consumers’ brand attitudes in storytelling ads
Authors: Chen Tingting , Fan Xinqiao , He Jiayu , Fan Jun , Chen Wei
Published: July 2024

Introduction

Storytelling ad is presented from one or more narrative perspectives. Narrative perspective, which can alter the way in which the plot is physiologically or psychologically perceived, can significantly affect consumer experience.

Methods

This study conducts three experiments with 526 participants to analyze the influencing mechanism of narrative perspective (first- versus third-person) on consumers’ brand attitudes in storytelling ads of products with different involvement (high versus low).

Results

(a) Narrative perspective (first- versus third-person) exerts persuasive effects on consumer brand attitudes; (b) Processes of social presence and self-brand connection explain the effects of narrative perspective on brand attitudes; (c) When product involvement is high, the use of the first-person narrative perspective in storytelling ads will result in a more positive brand attitude than the use of third-person narrative will; With lower product involvement, there is no significant difference in the impact on brand attitudes regardless of narrative perspective (first-person versus third-person).

Discussion

This research finds that different narrative perspectives significantly impact the persuasiveness of advertising. Boundary conditions exist for the effect of narrative persuasion, and product involvement moderates the effect of narrative perspective on brand attitudes.
Exploring the meaning of life among Chinese adolescents with nephrotic syndrome: determinants and psychological correlates
Authors: Liang Ying , Huang Ruijie , Luo Xiuzhuang , Mo Shuyan , He Zhichuan , Tian Junhong , Yang Lijuan , Xue Yi , Luo Xiaomi
Published: July 2024

Background

Adolescents with Nephrotic Syndrome (NS) confront unique challenges that influence their Meaning of Life (MOL), a concept crucial for psychological resilience. The chronic nature of NS and its associated burdens necessitate a deeper exploration of MOL and its determinants within this demographic, previously underexamined in research. This study aims to investigate MOL among Chinese adolescents with NS, identifying key factors influencing their sense of meaning and examining the interrelations with Subjective Well-Being (SWB) and Psychological Security (PS).

Methods

Employing a cross-sectional survey design, we analyzed 150 adolescents with NS from Baise City, Guangxi, using the Purpose in Life (PIL) scale alongside PS and SWB scales. Sociodemographic and disease-related variables were assessed for their impact on MOL. Data analysis included descriptive statistics, multiple linear regression, and correlation analyses to explore predictors of MOL and its association with SWB and PS.

Results

A significant proportion (62.0%) of participants exhibited MOL scores below the threshold, indicating diminished life meaning. Critical factors impacting MOL included ‘left-behind’ status, family structure, educational disruptions, and NS duration. Strong correlations emerged between MOL, SWB (r = 0.70, p < 0.01), and PS, highlighting the interdependence of these psychological dimensions. The study further revealed ‘Proactivity’ as a vital component of MOL, suggesting that despite their challenges, adolescents with NS maintain a keen engagement with life. Key aspects such as ‘Certainty in Control’, ‘Mood of Melancholy or Pleasure’, and ‘Vitality’ emerged as crucial for intervention.

Conclusion

The findings underline the profound impact of NS on adolescents’ MOL, influenced by both sociodemographic and disease-specific factors. By identifying key areas for psychological intervention, this study contributes to the holistic care and treatment of adolescents with NS, advocating for integrated approaches that address their unique challenges and support systems.
How are poor sleepers with other clinical conditions affected by maladaptive personality traits? A neural network-based analysis
Authors: Khazaie Habibolah , Rezaei Farzin , Zakiei Ali , Faridmarandi Behrooz , Komasi Saeid
Published: July 2024

Background

Psychopathology research mainly focused on the cross-sectional and longitudinal associations between personality and psychiatric disorders without considering the moment-to-moment dynamics of personality in response to environmental situations. The present study aimed to both cluster a young sample according to three mixed clinical conditions (poor sleep quality, depression, and somatization) and to predict the derived clusters by maladaptive personality traits and sex differences using a deep machine learning approach.

Methods

A sample of 839 adults aged 18-40 years (64% female) from the west of Iran were clustered according to the mixed clinical conditions using the cluster analysis techniques. An Artificial Neural Network (ANN) modeling is used to predict the derived clusters by maladaptive personality traits and biological gender. A receiver operating characteristic (ROC) curve was used to identify independent variables with high sensitivity specific to the derived clusters.

Results

The cluster analysis techniques suggested a fully stable and acceptable four-cluster solution for Depressed Poor Sleepers, Nonclinical Good Sleepers, Subclinical Poor Sleepers, and Clinical Poor Sleepers. The ANN model led to the identification of one hidden layer with two hidden units. The results of Area under the ROC Curve were relatively to completely acceptable, ranging from.726 to.855. Anhedonia, perceptual dysregulation, depressivity, anxiousness, and unusual beliefs are the most valuable traits with importance higher than 70%.

Conclusion

The machine learning approach can be well used to predict mixed clinical conditions by maladaptive personality traits. Future research can test the complexity of normal personality traits connected to mixed clinical conditions.
The impact of digital economy development on public health: evidence from Chinese cities
Authors: Li Hao , Li Yu
Published: July 2024

Introduction

The swift advancement of the digital economy not only plays a crucial role in stimulating a country’s economic growth but also exerts a significant influence on national health and well-being.

Methods

Adopts the data of 285 prefecture-level cities in China from 2010 to 2022, and employs the panel data fixed-effects model, spatial Durbin model, and mediated effects model to study the impact of digital economic development on the level of urban public health.

Results

It is found that digital economic development significantly improves the level of urban public health, and the effect has a spatial spillover effect. The impact of digital economic development on urban public health is mainly concentrated in cities with higher levels of economic development, higher levels of digital economic development, and lower levels of urban public health. Among them, technological innovation and information dissemination are the main dissemination channels through which digital economic development affects the level of urban public health.

Discussion

The advancement of the digital economy significantly impacts urban public health. It is advisable to bolster policies guiding digital economy development, enhance cross-sector collaboration between the digital economy and public health, reinforce public health education and awareness campaigns, improve the digital health literacy of the population, continue to enhance the fairness and accessibility of basic medical services, and address and bridge the “digital divide” between regions, as well as urban and rural areas.
Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID
Authors: Polizzi Jessica , Tosto-Mancuso Jenna , Tabacof Laura , Wood Jamie , Putrino David
Published: July 2024

Introduction

Long COVID involves debilitating symptoms, many of which mirror those observed with dysautonomia, and care must be taken with rehabilitation for autonomic dysfunction to avoid post-exertional malaise/post-exertional symptom exacerbation. Resonant breathing (breathing slowly at a defined rate of breaths per minute) requires less exertion and can potentially improve autonomic function. The objective of this work was to report on the impact of a resonant breathing program on self-reported symptoms and wellbeing in people with Long COVID.

Methods

A retrospective analysis of de-identified data was completed in a convenience sample of people with Long COVID, who participated in the Meo Health (formerly known as Stasis HP) resonant breathing program. Participants completed baseline and follow up surveys.

Results

Data were available for 99 participants. Most measures of symptoms and wellbeing improved at follow up, with the largest differences per participant seen in sense of wellness (47.3%, p < 0.0001), ability to focus (57.5%, p < 0.0001), ability to breathe (47.5%, p < 0.0001), ability to control stress (61.8%, p < 0.0001) and sleep quality (34.9%, p = 0.0002). Most (92%) participants reported improvement at follow up on the Patient Global Impression of Change Scale.

Conclusion

Self-reported symptoms and wellbeing improved in people with Long COVID completing resonant breathing. Resonant breathing can be considered as an option within the broader treatment plan of people with Long COVID.
Comparative subcutaneous and submuscular implantation of an electroencephalography device for long term electroencephalographic monitoring in dogs
Authors: Rogers Casey B. , Meller Sebastian , Meyerhoff Nina , Volk Holger A.
Published: July 2024

Background

Implantable electroencephalography (EEG) recording devices have been used for ultra-long-term epilepsy monitoring both in clinical and home settings in people. Objective and accurate seizure detection and recording at home could be of great benefit in diagnosis, management and research in canine idiopathic epilepsy (IE). Continuous EEG monitoring would allow accurate detection of seizure patterns, seizure cycles, and seizure frequency. An EEG acquisition system usable in an “out of clinic” setting could improve owner and veterinary compliance for EEG diagnostics and seizure management.

Objectives

Whether a subcutaneous ultra-long term EEG monitoring device designed for humans could be implanted in dogs.

Animals

Cadaver study with 8 medium to large breed dogs.

Methods

Comparatively using a subcutaneous and submuscular approach to implant the UNEEG SubQ-Implant in each dog. Positioning was controlled via CT post implantation and cranial measurements were taken.

Results

In four of the eight dogs a submuscular implantation without any complications was possible. Complications were close contact to the optic nerve in the first approaches, before the implantation angle was changed and in the smallest dog contact of the implant with the orbital fat body. Cranial measurements of less than 95 mm length proved to be too small for reliable implantation via this approach. The subcutaneous approach showed severe limitations and the implant was prone to dislocation.

Conclusion

The UNEEQ SubQ-Implant can be implanted in dogs, via submuscular approach. CT imaging and cranial measurements should be taken prior to implantation.
Semianalytical Research on Aerothermoelastic Behaviors of Functionally Graded Plates under Arbitrary Temperature Fields in Hypersonic Vehicles
Authors: Li Chang , Wan Zhiqiang , Wang Xiaozhe , Yang Chao , Li Keyu
Published: July 2024

Hypersonic vehicles are susceptible to considerable aerodynamic heating and noticeable aerothermoelastic effects during flight due to their high speeds. Functionally graded materials (FGMs), which enable continuous changes in material properties by varying the ratio of different materials, provide both thermal protection and load-bearing capabilities. Therefore, they are widely used in thermal protection structures for hypersonic vehicles. In this work, the aerothermoelastic behaviors of functionally graded (FG) plates under arbitrary temperature fields are analyzed via a semianalytical method. This research develops a method considering the influence of thermal loading, specifically the decrease in stiffness due to thermal stresses, as well as the correlation between material properties and temperatures under arbitrary temperature fields, based on Ritz’s method. The classical plate theory, von–Karman’s large defection plate theory and piston theory are employed to formulate the strain energy, kinetic energy and external work functions of the system. This paper presents a novel analysis of static aerothermoelasticity of FG plates, in addition to the linear/nonlinear flutter under arbitrary temperature fields, such as uniform, linear and nonlinear temperature fields. In addition, the effects of the volume fraction index, dynamic pressure, and temperature increase on the aerothermoelastic characteristics of FG plates are analyzed.
A Novel Approach Using Non-Experts and Transformation Models to Predict the Performance of Experts in A/B Tests
Authors: Stranger Phillip , Judmaier Peter , Rottermanner Gernot , Rokitansky Carl-Herbert , Szilagyi Istvan-Szilard , Settgast Volker , Ullrich Torsten
Published: July 2024

The European Union is committed to modernising and improving air traffic management systems to promote environmentally friendly air transport. However, the safety-critical nature of ATM systems requires rigorous user testing, which is hampered by the scarcity and high cost of air traffic controllers. In this article, we address this problem with a novel approach that involves non-experts in the evaluation of expert software in an A/B test setup. Using a transformation model that incorporates auxiliary information from a newly developed psychological questionnaire, we predict the performance of air traffic controllers with high accuracy based on the performance of students. The transformation model uses multiple linear regression and auxiliary information corrections. This study demonstrates the feasibility of using non-experts to test expert software, overcoming testing challenges and supporting user-centred design principles.
Carbon Sequestration by Tropical Trees and Crops: A Case Study of Oil Palm
Authors: Murphy Denis J.
Published: July 2024

Carbon sequestration by photosynthetic organisms is the principal mechanism for the absorption of atmospheric CO2. Since the 1950s, however, the global carbon cycle has been distorted as increased anthropogenic CO2 emissions have greatly outstripped rates of carbon sequestration, with a 50% increase in atmospheric CO2 levels in less than a century, leading to perturbation of global climate systems and threatening food production and social stability. In order to address the current imbalance in CO2 flux, it is important to both reduce net emissions and promote sequestration. To address the latter issue, we need to better understand the roles of systems, such as natural forests, coastal wetlands, and tropical croplands, in carbon sequestration and devise strategies to facilitate net CO2 uptake. Carbon sequestration by tropical trees and crops already removes in excess of 1000 million tonnes of atmospheric CO2 annually but is threatened by anthropogenic activities such as deforestation and the drainage of carbon-rich peatland. Improvements in carbon sequestration can be achieved by policies such as growing tropical crops as part of agroforestry systems, enforcing limitations on deforestation and the use of peatland, and auditing the carbon impact of major cropping systems in order to focus on those crops that deliver both high yields and carbon efficiency. As an initial step in this process, a detailed case study is presented on the tropical tree crop, the African oil palm, Elaeis guineensis. This analysis includes a comparison of the carbon sequestration potential of oil palm with that of tropical forests and other oil crops, the biomass sequestration potential of oil palm and current and future strategies aimed at achieving net-zero carbon targets for oil palm and related crops.
Designating Airsheds in India for Urban and Regional Air Quality Management
Authors: Guttikunda Sarath K.
Published: July 2024

Air pollution knows no boundaries, which means for a city or a region to attain clean air standards, we must not only look at the emission sources within its own administrative boundary but also at sources in the immediate vicinity and those originating from long-range transport. And there is a limit to how much area can be explored to evaluate, govern, and manage designated airsheds for cities and larger regions. This paper discusses the need for an official airshed framework for India’s air quality management and urban airsheds designated for India’s 131 non-attainment cities under the national clean air program, and proposes climatically and geographically appropriate regional airsheds to support long-term planning. Between 28 states, eight union territories, 36 meteorological sub-regional divisions, and six regional meteorological departments, establishing the proposed 15 regional airsheds for integrated and collaborative air quality management across India is a unique opportunity.
Effects of β-Mannanase Supplementation and Soyhull Inclusion on Production Performance, Economics, Egg Quality, Blood Biochemicals, Nutrient Digestibility, and Intestinal Morphology in Golden Brown Hens (RIR × Fayoumi) during Late Peak Production
Authors: Shuaib Muhammad , Hafeez Abdul , Tahir Muhammad , Sufyan Abubakar , Ullah Obaid , Shams Muhammad Adnan , Siddiqui Shahrood Ahmed , Swelum Ayman A.
Published: July 2024

This study investigated the effects of the β-mannanase enzyme and soyhulls on production performance, economics, egg quality, hematology and serum biochemistry, nutrient digestibility, gut morphology, digesta viscosity, and excreta consistency in laying hens during the late peak production phase (37 to 40 weeks of age). Golden brown hens (RIR × Fayoumi; n = 200) were fed a control diet (no soyhulls or enzymes) and diets containing four combinations, i.e., 3% soyhulls with 20 mg/kg β-mannanase (D1), 3% soyhulls with 30 mg/kg β-mannanase (D2), 9% soyhulls with 20 mg/kg β-mannanase (D3), and 9% soyhulls with 30 mg/kg β-mannanase (D4), for four weeks in four replicates of 10 birds each. Overall, a significantly higher (p < 0.05) feed intake, weight gain, feed conversion ratio, and water intake were calculated in the D2 group as compared to the control and remaining combinations of soyhulls and β-mannanase. No mortality was recorded during the entire experiment. Economically, the D1 and D2 groups showed the best results as compared to the D3 and D4 groups. Egg quality parameters like egg weight, shell weight and shell thickness, yolk weight, albumen weight and height, and the Haugh unit remained unchanged (p > 0.05). Similarly, the D2 group showed significantly lower total cholesterol, LDL, and VLDL levels and enhanced gut morphology with greater villus width, height, crypt depth, and surface area across intestinal segments. Crude protein (CP), crude fiber (CF), crude fat, and ash digestibility were higher (p < 0.05) in the D1 and D2 groups compared to the control. Digesta viscosity, excreta consistency, and other egg quality parameters remained unaffected. In conclusion, the dietary inclusion of a combination of 3% soyhulls and 30 mg/kg β-mannanase may have potential benefits for laying hens by improving some production performance and egg quality indicators and economics, lowering blood cholesterol, LDL, and VLDL levels, enhancing nutrient digestibility, and improving gut morphology without affecting egg quality.
Insect Larvae as an Alternate Protein Source in Poultry Feed Improve the Performance and Meat Quality of Broilers
Authors: Sajjad Muhammad , Sajjad Asif , Chishti Ghazanfar Ali , Khan Ehsaan Ullah , Mozūraitis Raimondas , Binyameen Muhammad
Published: July 2024

The primary challenge facing the global animal industry is the scarcity of protein feed resources. Various insects are gaining prominence as innovative feed sources due to their economic, environmentally friendly, and nutritious attributes. The purpose of the present study was to determine the effects of a partial replacement of soybean meal with fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae) and black soldier fly Hermetia illucens (Diptera: Stratiomyidae) on the growth performances, blood parameters, gut histology, and meat quality of broilers. A total of 350 1-day-old (40 ± 0.15 g) male chicks (Ross 308) were randomly assigned to seven experimental meals. Each treatment was repeated five times with 50 birds per dietary treatment. The seven dietary treatments included 4, 8, and 12% replacements of SBM with larvae of S. frugiperda and H. illucens. SBM was the basal diet considered the control. The data showed that broilers fed 12% S. frugiperda or H. illucens exhibited a significantly higher (p < 0.05) live weight, average daily weight gain, and improved the feed conversion ratio. Meals with 12% S. frugiperda or H. illucens significantly enhanced (p < 0.05) haematological and gut histological parameters, including villus height, crypt depth, villus width, and villus height/crypt depth ratios. The meat of broilers fed the 12% S. frugiperda diet showed significantly higher (p < 0.05) lightness and yellowness. Replacing soybean meal up to 12% with either S. frugiperda or H. illucens larvae improves the growth performance, blood haematology, gut morphometry, and meat quality traits of broilers.
Point Mutations in Furazolidone and Rifampicin Resistance Genes in Helicobacter pylori Strains from Colombia
Authors: Guzman Kevin Andres , Hidalgo Arsenio , Pazos Alvaro Jairo
Published: July 2024

The eradication of Helicobacter pylori is a valid strategy for preventing gastric cancer; however, the therapeutic failure of first-line treatments in Colombia is associated with high resistance to metronidazole and amoxicillin. This study explored alternative antibiotics and analyzed point mutations in resistance genes to furazolidone and rifampicin in order to include them in rescue therapy regimens. A total of 239 complete genomes of Helicobacter pylori Colombian strains were compared to that of the ATCC 26695 strain to identify mutations in the rpoB and porD genes for rifampicin and furazolidinone resistance, respectively. While rifampicin resistance mutations were not found, only 0.84% of the isolates showed the porD gene, suggesting that Helicobacter pylori is sensitive to these antibiotics. A phylogenomic analysis of Helicobacter pylori revealed an independent lineage in Colombia (hspColombia). The absence of point mutations in the rpoB gene, together with the scarce mutations identified in the porD gene of Helicobacter pylori, suggest that the hspColombia isolates are sensitive to rifampicin and furazolidone, which could be key to including these antibiotics in the rescue therapies against Helicobacter pylori.
Optimization Research of Heterogeneous 2D-Parallel Lattice Boltzmann Method Based on Deep Computing Unit
Authors: Tao Shunan , Li Qiang , Zhou Quan , Han Zhaobing , Lu Lu
Published: July 2024

Currently, research on the lattice Boltzmann method mainly focuses on its numerical simulation and applications, and there is an increasing demand for large-scale simulations in practical scenarios. In response to this situation, this study successfully implemented a large-scale heterogeneous parallel algorithm for the lattice Boltzmann method using OpenMP, MPI, Pthread, and OpenCL parallel technologies on the “Dongfang” supercomputer system. The accuracy and effectiveness of this algorithm were verified through the lid-driven cavity flow simulation. The paper focused on optimizing the algorithm in four aspects: Firstly, non-blocking communication was employed to overlap communication and computation, thereby improving parallel efficiency. Secondly, high-speed shared memory was utilized to enhance memory access performance and reduce latency. Thirdly, a balanced computation between the central processing unit and the accelerator was achieved through proper task partitioning and load-balancing strategies. Lastly, memory access efficiency was improved by adjusting the memory layout. Performance testing demonstrated that the optimized algorithm exhibited improved parallel efficiency and scalability, with computational performance that is 4 times greater than before optimization and 20 times that of a 32-core CPU.