bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitamin D Receptor Polymorphisms in the Turkish Population are not associated with Multiple Sclerosis
Authors: Hoscan AY , Bulan Batuhan , Keskin Sena Nur , Cavus Ayse , Culcu Elif Asena , Isik Nihal , List Edward O. , Arman Ahmet
Published: February 2020

Background Multiple sclerosis (MS) is an inflammatory disease characterized by demyelination and axonal degeneration affecting the central nervous system (CNS). Unfortunately, very little is known about the etiology of this disease. Among the genetic factors suggested to be associated with this disease are polymorphisms to the vitamin D receptor (VDR). However, there is disagreement in the literature on this topic. Therefore, we tested the hypothesis that polymorphisms in the vitamin D receptor (VDR) are also associated with MS. Aim The aim of the study was to investigate the relationship of MS disease with VDR Fok-I, Bsm-I and Taq-I polymorphisms in Turkish population. Method This study contains 175 MS patients and 183 healthy controls. Blood samples were taken from each subject to isolate genomic DNA by salting out method. VDR gene Fok-I, Bsm-I and Taq-I polymorphism regions for each patient and control were amplified by polymerase chain reaction (PCR). The PCR products were digested, and the genotypes were determined based on size of digested PCR products. Results No correlation was found between MS disease and VDR Fok-I, Bsm-I and Taq-I polymorphisms for genotype distribution (Pearson test, p>0,05 ) or allele frequency (Pearson test, p>0,05 ). No meaningful association was found between subtypes of MS for genotypes distribution and allele frequencies of Fok-I, Bsm-I and Taq-I polymorphisms (Pearson test, p>0,05 ). Conclusion There is no association between VDR gene polymorphisms (Fok-I, Bsm-I and Taq-I) and MS disease in Turkish population.
Mass spectra analysis of quinoline alkaloids detected in Sauuda fruticose leads to novel biosynthesis pathway of quinoline alkaloids
Authors: Al-ghazzawi Adel M. , Alshehri Mohammed A , Deeb Ahmad A , zarga Musa H Abu , Alalmie Ali Y
Published: February 2020

Alkaloids reported to have a wide range of biological activity moreover, the biological effects of alkaloids depends on the type of the alkaloids and since the phytochemical screening studies on Suaeda fruticosa indicates the presence of alkaloids but they did not determine the types of the alkaloids present on this plant. Consequently, the LC-MS/MS analysis of the alkaloidal part of Suaeda fruticosa leave extarct reveals the presence of six quinoline alkaloids beside that mass spectra analysis of the present quinoline alkaloids leads to suggest a new biosynthetic pathway of quinoline alkaloids.
Screening of tumor microenvironment-related prognostic genes in breast cancer by data mining
Authors: LI Yunhui , REN Na
Published: February 2020

Background Accumulating evidence has demonstrated that the components of tumor immune microenvironment (TME) play important roles in breast cancer (BC) initiation, progression and prognosis. Materials and methods We downloaded the TCGA, GSE12276, GSE58812 and GSE42568 datasets. We calculated the immune scores and tumor immune infiltrating cells (TIICs) of TCGA-BRCA and GEO datasets using ESTIMATE and CIBERSORT algorithm, respectively. Then, the overlapping immune-related differentially expressed genes (DEGs) were screened using R ‘limma ’ package between TCGA and GSE12276 datasets. The GO and KEGG enrichment analysis were used to predict the function and signaling pathways of common DEGs. Finally, we extracted a series of tumor immune microenvironment-related genes, and explore the relationship between these genes and clinical outcomes in TCGA, GSE58812 and GSE42568 datasets. Results Based on the ESTIMATE algorithm, the immune scores were significantly associated with cancer types, as well as overall survival in BC patients. The fractions of some TIICs, such asnaïve B cells, memory B cells, CD8 + T cells, resting CD4 + memory T cells, activated CD4 + memory T cells, resting NK cells, monocytes, macrophage M0, M1, M2, resting DCs, activated DCs and resting mast cells, were significantly different between low and high immune score groups (all P <0.05). The DEGs between low and high immune score groups were mainly involved in immune-related biological processes, including adaptive immune response, innate response and inflammatory response. Finally, we found that ACSL5, GIMAP2, HLA-DRA and CLEC10A were significantly associated with prognosis among TCGA, GASE58812 and GSE42568 datasets (all P <0.05). Conclusion These findings provide a more comprehensive understanding of immune cells and immune-related genes within TME as well as prognosis-related genes in BC. Future studies need to perform in vivo and in vitro experiments to clarify the mechanisms of these genes in TME and provide a comprehensive idea to immune therapy.
Helicobacter pylori genotypes, salt intake, and sociodemographic factors associated with premalignant gastric lesions in a Colombian population. A case control study.
Authors: Carlosama Yeison Harvey , Astaiza Claudia Patricia Acosta , Torres Carlos Hernan Sierra , Bravo Harold Bolaños
Published: February 2020

IntroductionGenetic variability of Helicobacter pylori is associated with various gastrointestinal diseases; however, little is known about its interaction with sociodemographic and dietary factors in the development of premalignant lesions.ObjectiveTo evaluate the association among Helicobacter genotypes, salt intake, and sociodemographic factors associated with precursor lesions of the stomachMaterials and MethodsAn analytical study was conducted including cases (patients with gastric atrophy, intestinal metaplasia, and gastric dysplasia) and controls (patients with nonatrophic gastritis). Sociodemographic information and information about salt intake were obtained using a questionnaire. Histopathological diagnosis was performed according to the Sydney System. The cagA and vacA genotypes were established using polymerase chain reaction in paraffin blocks. ANOVA was used for analyzing quantitative variables. Categorical variables are presented as proportions and absolute frequencies. The effect of each variable on the study outcome (premalignant lesion) is presented as odds ratio (OR) and 95% CI. A p-value of <0.05 was considered as statistically significant.ResultsThe vacA/s1m1 genotype increases the risk of developing precursor lesions of the stomach (OR: 3.82, 95% CI: 1.45–10.07, p = 0.007). Age and salt intake showed a positive interaction with the s1m1 genotype (adjusted OR: 5.19, 95% CI: 1.88–14.32, p = 0.001) and with bacterial coinfection (adjusted OR: 3.2, 95% CI: 1.06–9.59, p = 0.038). The cagA genotype was not correlated to the development of premalignant lesions of the stomach (OR: 1.21, 95% CI: 0.80–1.82, p = 0.361).ConclusionsThe vacA genotype, age, and salt intake are indicators of the risk of developing premalignant lesions of the stomach in the study population.
Investigations of the few-nucleon systems within the LENPIC project
Authors: Golak Jacek , Epelbaum Evgeny , Grassi Alessandro , Hiroyuki Kamada , Krebs Hermann , Reinert Patrick , Skibiński Roman , Soloviov Volodymyr , Topolnicki Kacper , Urbanevych Vitalii , Volkotrub Yuriy , Witała Henryk
Published: February 2020

Results presented in this contribution are obtained within the Low
Energy Nuclear Physics International Collaboration (LENPIC). LENPIC aims
to develop chiral nucleon-nucleon and many-nucleon interactions complete
through at least the fourth order in the chiral expansion. These
interactions will be used together with consistently derived current
operators to solve the structure and reactions of light and medium-mass
nuclei including electroweak processes. In this contribution the current
status of the chiral nuclear forces and current operators will be
briefly discussed. A special role played by the calculations of
nucleon-deuteron scattering will be explained.
Measurement of spin correlation coefficients p-$^{3}$He scattering at 65 MeV
Authors: Inoue Minami , Sekiguchi Kimiko , Miki Kenjiro , Watanabe Atomu , Nakai Shinnosuke , Shibuya Shun , Sakai Daisuke , Utsuki Yuta , Umetsu Hiroo , Hatanaka Kichiji , Kanda Hiroki , Ong Hooi Jin , Wakasa Tomotsugu , Goto Syuhei , Mitsumoto Shinji , Inomoto Daiki , Kasahara Hina , Ino Takashi , Sakai Hideyuki , Maeda Yukie , Nonaka Kotaro , Wakui Takashi , Itoh Masatoshi
Published: February 2020

We performed the experiment of p–^{3}3He
scattering at 65 MeV by using polarized proton beams and the newly
constructed polarized ^{3}3He
target. The proton analyzing power A_{y}Ay,
the ^{3}3He
analyzing power A_{y}^{T}AyT,
and the spin correlation coefficient C_{yy}Cyy
were measured. In the conference, the experimental data were compared
with the rigorous numerical calculations based on various nuclear
potentials. Large discrepancies between the experimental data and the
calculations were found in the A_{y}^{T}AyT
and the {C_{yy}}Cyy
at the backward angles.
Clustering in $^{18}$O - absolute determination of branching ratios via high-resolution particle spectroscopy
Authors: Pirrie Stuart , Wheldon Carl , Kokalova Tzany , Bishop Jack , Hertenberger R. , Wirth H.-F. , Bailey Stephanie , Curtis Neil , Dell'Aquila Daniele , Faestermann Thomas , Mengoni D. , Smith Robin , Torresi Domenico , Turner Ari
Published: February 2020

The determination of absolute branching ratios for high-energy states
in light nuclei is an important and useful tool for probing the
underlying nuclear structure of individual resonances: for example, in
establishing the tendency of an excited state towards
\alphaα-cluster
structure. Difficulty arises in measuring these branching ratios due to
similarities in available decay channels, such as
(\mathbf{^{18}}18O,\mathbf{n}𝐧)
and (\mathbf{^{18}}18O,\mathbf{2n}2𝐧),
as well as differences in geometric efficiencies due to population of
bound excited levels in daughter nuclei. Methods are presented using
Monte Carlo techniques to overcome these issues.
The Physical Consequence to Knowing: A speculative report
Authors: pavleheidler
Published: February 2020

This is my first attempt at approaching the notion of agency as a practice though the mode of dancing and writing; deconstructing and reconstructing what I know experientially and what I am trying to comprehend theoretically. I am looking for a way of releasing bodily capacities from the jurisdiction of the mind, whose cartesian definition I don't attempt to deny, as most people I have the chance to work with and teach exhibit in one way or another proof of the fact they’ve embodied the concept. All the while, I am considering philosophical texts, anatomical texts, and (science) fiction; I am taking into account my bodily experience, I am dancing and I am writing, I am teaching, conversing, occasionally making progress, occasionally falling back to the embrace of old habits, making unnecessary assumptions, and failing. Repetition is a part of the study. Minimal difference is a part of the study. Changing perspective is a part of the study. My strategy includes not trying to fix but approach with care and attention every step I am taking; every achievement, every set-back; every question and every answer. I assume my learning curve to be cyclical, as I continue to practice in public, always vulnerable but eager to engage in an exchange.
Methods of ensuring flexibility of the budget process at holding enterprises of energy industry
Authors: Mints Oleksii , Markina Natalia
Published: February 2020

Achieving business success for a company is directly related to financial planning, budgeting and analysis of results. Any system is viable if it includes feedback elements that provide an analysis of what the system has done and current adjustments to the system’s behavior as signals about its state. The article deals with the features of the budget process at energy enterprises as part of vertically oriented holding structures. The system formed by such enterprises is very complex, so it is necessary to take additional measures to maintain the efficiency of the budget process in such conditions. Therefore, an important issue is the organization of effective control in the budget execution system to make operational management decisions, which turns it into an effective tool for managing the enterprise. The essence and importance of budget control of energy companies are revealed. The paper deals with the organization of budget planning at an enterprise of the energy industry. Models for budget development and budget execution processes were built and budget limits were adjusted for enterprises using the IDEF0 methodology. The methods of control over the budget execution of energy industry enterprises are considered. The essence and types of the process of adjusting the budget of enterprises are revealed.
Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy
Authors: Zajakina Anna , Spunde Karina , Lundstrom Kenneth
Published: February 2020

Background:

The lack of specific and efficient cancer therapies has influenced the development of
novel approaches, such as immunotherapy, which from its original application of immunogenic protein delivery
has developed into the use of more sophisticated recombinant gene delivery methods to achieve better safety and
efficacy profiles. This approach involves viral and non-viral delivery systems.

Methods:

Expression vectors have been engineered for alphaviruses, including Semliki Forest virus, Sindbis virus
and Venezuelan equine encephalitis virus. For immunotherapeutic applications, recombinant particles, RNA
replicons and layered DNA vectors that express tumor-associated antigens (TAAs) and cytokines have been studied
in animal models and in a few clinical trials.

Results:

Immunization studies with TAAs and cytokines have elicited strong antibody responses and vaccination
has provided protection against challenges with tumor cells in mouse models. Furthermore, the combination of
TAAs and cytokines, antibodies and growth factors and the co-administration of chemotherapeutics and bacteriabased
adjuvants have enhanced immunogenicity. Intratumoral and systemic delivery of recombinant alphavirus
particles has demonstrated significant tumor regression and prolonged survival rates in rodent tumor models.

Conclusion:

Alphavirus-based immunotherapy represents a rapid and efficient method for prophylactic and
therapeutic applications in animal models.
DNA Base Excision Repair: The Achilles' Heel of Tumour Cells and their Microenvironment?
Authors: Poletto Mattia , Legrand Arnaud J. , Dianov Grigory L.
Published: February 2020

Our current understanding of cancer suggests that every tumour has individual features. Approaches to
cancer treatment require thorough comprehension of the mechanisms triggering genomic instability and protecting
cancer cells from therapeutic treatments. Base excision repair (BER) is a frontline DNA repair system that is
responsible for maintaining genome integrity. The BER pathway prevents the occurrence of disease, including
cancer, by constantly repairing DNA base lesions and DNA single strand breaks caused by endogenous and exogenous
mutagens. BER is an important DNA repair system for cancer cell survival, as it can affect both chemoand
radio-resistance of tumours. Variations in BER capacity are likely responsible for a number of cases of sporadic
cancer and may also modulate cancer sensitivity and resistance to therapeutic treatments. For these reasons,
it is broadly accepted that targeting BER enzymes might be a promising approach to personalised anti-cancer
therapy. However, recent advances in both treatment strategies and the comprehension of cancer development call
for a better understanding of the consequences of BER inhibition. Indeed, the impact on both the tumour microenvironment
and healthy tissues is still unclear. This review will summarise the current status of the approaches
exploiting BER targeting, describing the most promising small molecule inhibitors and synthetic lethality strategies,
as well as potential limitations of these approaches.
Prostate Cancer: Biology, Incidence, Detection Methods, Treatment Methods, and Vaccines
Authors: Bartzatt Ronald
Published: February 2020

Cancer of the prostate are cancers in which most incidences are slow-growing, and in the U.S., a record of 1.2 million new cases of prostate cancer occurred in 2018. The rates of this type of cancer have been increasing in developing nations. The risk factors for prostate cancer include age, family history, and obesity. It is believed that the rate of prostate cancer is correlated with the Western diet. Various advances in methods of radiotherapy have contributed to lowering morbidity. Therapy for hormone- refractory prostate cancer is making progress, for almost all men with metastases will proceed to hormone-refractory prostate cancer. Smoking cigarettes along with the presence of prostate cancer has been shown to cause a higher risk of mortality in prostate cancer. The serious outcome of incontinence and erectile dysfunction result from the cancer treatment of surgery and radiation, particularly for prostate- specific antigen detected cancers that will not cause morbidity or mortality. Families of patients, as well as patients, are profoundly affected following the diagnosis of prostate cancer. Poor communication between spouses during prostate cancer increases the risk for poor adjustment to prostate cancer. The use of serum prostate-specific antigen to screen for prostate cancer has led to a greater detection, in its early stage, of this cancer. Prostate cancer is the most common malignancy in American men, accounting for more than 29% of all diagnosed cancers and about 13% of all cancer deaths. A shortened course of hormonal therapy with docetaxel following radical prostatectomy (or radiation therapy) for high-risk prostate cancer has been shown to be both safe and feasible. Patients treated with docetaxel-estramustine had a prostate-specific antigen response decline of at least 50%. Cancer vaccines are an immune-based cancer treatment that may provide the promise of a non-toxic but efficacious therapeutic alternative for cancer patients. Further studies will elucidate improved methods of detection and treatment.
Computational Study on the Kinetics and Mechanisms of Unimolecular Reactions of (Z)-(Z)-N-(λ5-phosphanylidene) Formohydrazonic Formic Anhydride: Intramolecular aza-Wittig Reaction in Competition with Mumm Rearrangement
Authors: Mirdoraghi Somayeh , Douroudgari Hamed , Piri Farideh , Vahedpour Morteza
Published: February 2020

For (Z)-(Z)-N-(λ5-phosphanylidene) formohydrazonic formic anhydride, Aza-Wittig reaction
and Mumm rearrangement are studied using both density functional and coupled cluster theories.
For this purpose, two different products starting from one substrate are considered that are competing
with each other. The obtained products, P1 and P2, are thermodynamically favorable. The product of
the aza-Wittig reaction, P1, is more stable than the product of Mumm rearrangement (P2). For the mentioned
products, just one reliable pathway is separately proposed based on unimolecular reaction.
Therefore, the rate constants based on RRKM theory in 300-600 K temperature range are calculated.
Results show that the P1 generation pathway is a suitable path due to low energy barriers than the path
P2. The first path has three steps with three transition states, TS1, TS2, and TS3. The P2 production
path is a single-step reaction. In CCSD level, the computed barrier energies are 14.55, 2.196, and 10.67
kcal/mol for Aza-Wittig reaction and 42.41 kcal/mol for Mumm rearrangement in comparison with the
corresponding complexes or reactants. For final products, the results of the computational study are in
a good agreement with experimental predictions.
Integrating Regulatory Drug Label Information to Facilitate Evaluation of Adverse Events in Pharmacovigilance
Authors: Hui Tom Z.
Published: February 2020

Background:

Efficiency and accuracy for signal detection and evaluation activities are
integral components of routine Pharmacovigilance (PV) practices. However, an Individual Case
Safety Report (ICSR) may consist of a variety of confounders such as Concomitant Medications
(CM), Past Medical History (PMH), and concurrent medical conditions that influence a safety officer’s
evaluation of a potential Adverse Event (AE). Limited pharmacovigilance systems are currently available
as a tool designed to enhance the efficiency and accuracy of signal detection and management.

Objective:

To introduce a systemic approach to make critical safety information readily available
for users in order to discern possible interferences from CM and make informed decisions on the
signal evaluation process – saving time while improving quality.

Methods:

Oracle Empirica Signal software was utilized to extract cases with CM that are Known
Implicating Medications (KIM) for each AE according to public regulatory information from drug
labels – FDA Structured Product Labeling (SPL) or EMA Summary of Product Characteristics
(SPC). SAS Enterprise Guide was used to further process the data generated from Oracle Empirica
Signal software.

Results:

For any target drug being evaluated for safety purposes, a KIM reference table can be generated,
which summarizes all potential causality contributions from CMs.

Conclusion:

In addition to providing standalone KIM table as reference, adoption of this concept
and automation may also be fully integrated into commercial signal detection and management
software packages for easy use and accessibility and may even lead to reduced False Positive rate in
signal detection within the PV space.
Barriers and Facilitators in Conducting Clinical Trials in Inflammatory Bowel Disease: A Monocentric Italian Survey
Authors: Larussa Tiziana , Suraci Evelina , Marasco Raffaella , Imeneo Maria , Dumitrascu Dan L. , Abenavoli Ludovico , Luzza Francesco
Published: February 2020

Background:

Clinical therapeutic trials are a fundamental tool for identifying and testing
new categories of drugs useful for ensuring clinical benefit in patients with Inflammatory Bowel
Diseases (IBD). A number of difficulties may affect the recruitment process in large clinical trials.

Objectives:

In order to increase the involvement of patients within clinical trials in IBD therapy, it is
necessary to identify which factors could facilitate or discourage participation. The aim of this study
was to evaluate the factors influencing the participation in clinical trials in a consecutive series of patients
with IBD from a single referral center from Southern Italy.

Methods:

Consecutive patients with Crohn´s Disease (CD) and Ulcerative Colitis (UC) were recruited
to complete a questionnaire dealing with their knowledge about clinical trials and attitudes towards
participation. Patients also completed the Short Inflammatory Bowel Disease Questionnaire
(S-IBDQ) to investigate their Quality of Life (QoL). Demographic and clinical data were recorded.

Results:

Of the 145 consecutive patients invited to the survey, 132 completed the survey (91%
response rate). Of them, 67% claimed their willingness to take part in a clinical therapeutic trial for
IBD. Multivariate analysis showed a significant positive association between interest in clinical trials
and previous experience (p = 0.014), high education (p < 0.001), poor QoL (p = 0.016), money
retributions (p = 0.03) and informative materials (p = 0.02). On the other hand, a long-standing
disease (p = 0.017), the possibility of receiving a placebo (p = 0.04) and the frequent colonoscopies
required by the study protocol (p = 0.04) were significantly associated with the lack of interest in
clinical trials.

Conclusion:

In a native local resident series of IBD patients, the majority of the patients were willing
to participate in a clinical therapeutic trial. A long-standing disease, placebo and invasive procedures
represented a barrier to enrollment while previous experience, high education, monetary compensation
and adequate information could be facilitative. Knowing barriers and facilitators affecting participation
in IBD clinical trials is of fundamental importance in order to increase the involvement of patients
in research and explore new treatment opportunities.
Classification of Chromosomal DNA Sequences Using Hybrid Deep Learning Architectures
Authors: Du Zhihua , Xiao Xiangdong , Uversky Vladimir N.
Published: February 2020

Background:

Chromosomal DNA contains most of the genetic information of
eukaryotes and plays an important role in the growth, development and reproduction of living
organisms. Most chromosomal DNA sequences are known to wrap around histones, and
distinguishing these DNA sequences from ordinary DNA sequences is important for understanding
the genetic code of life. The main difficulty behind this problem is the feature selection process.
DNA sequences have no explicit features, and the common representation methods, such as onehot
coding, introduced the major drawback of high dimensionality. Recently, deep learning models
have been proved to be able to automatically extract useful features from input patterns.

Objective:

We aim to investigate which deep learning networks could achieve notable
improvements in the field of DNA sequence classification using only sequence information.

Methods:

In this paper, we present four different deep learning architectures using convolutional
neural networks and long short-term memory networks for the purpose of chromosomal DNA
sequence classification. Natural language model Word2vec was used to generate word embedding
of sequence and learn features from it by deep learning.

Results:

The comparison of these four architectures is carried out on 10 chromosomal DNA
datasets. The results show that the architecture of convolutional neural networks combined with
long short-term memory networks is superior to other methods with regards to the accuracy of
chromosomal DNA prediction.

Conclusion:

In this study, four deep learning models were compared for an automatic classification
of chromosomal DNA sequences with no steps of sequence preprocessing. In particular, we have
regarded DNA sequences as natural language and extracted word embedding with Word2Vec to
represent DNA sequences. Results show a superiority of the CNN+LSTM model in the ten
classification tasks. The reason for this success is that the CNN module captures the regulatory
motifs, while the following LSTM layer captures the long-term dependencies between them.
Corynebacterium Striatum, an Emerging Nosocomial Pathogen: Case Reports
Authors: Datta Priya , Gupta Varsha , Gupta Menal , Pal Kritika , Chander Jagdish
Published: February 2020

Background::

Corynebacterium striatum is an emerging nosocomial pathogen, capable
of causing a variety of infections in immunocompromised and hospitalized patients.

Case Presentation:

We describe three cases of infection by C. striatum that were initially considered
as contamination. Clinical suspicion in the wake of predisposing factors and accurate identification,
using the Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry
(MALDI-TOF MS), were key to implicate this commensal bacterium as a cause of infection.
New Generalized Intuitionistic Fuzzy Divergence Measure with Applications to Multi-Attribute Decision Making and Pattern Recognition
Authors: Umar Adeeba , Saraswat Ram N.
Published: February 2020

Background:

The notion of fuzzy set was introduced by Zadeh. After that, many researchers
extended the concept of fuzzy sets in different ways. Atanassov introduced the concept
of intuitionistic fuzzy sets as an extension of fuzzy sets. This concept is applied in many fields such
as bio-informatics, image processing, decision making, feature selection, pattern recognition, etc.

Objectives:

The prime objective of this paper is to introduce a new generalized intuitionistic fuzzy divergence measure with proof of its validity and discussions on its elegant properties. Applications of the proposed divergence measure in multi-attribute decision making and pattern recognition are also discussed with some numerical illustrations. Further, the proposed divergence measure is compared with other methods for solving MADM and pattern recognition problems which exist in the literature.

Methods:

The divergence measure method is used to measure the divergence between two given
sets. In addition, the results of the other existing measures are also given to compare with the proposed
measure.

Results:

It was observed that the proposed divergence measure found much better results in comparison
with the other existing methods.

Conclusion:

A new divergence measure for intuitionistic fuzzy sets is introduced with some of its
properties. Applications of the proposed divergence measure to pattern recognition and MADM are
illustrated through examples. The comparison of the proposed method with the existing methods
shows the legacy of the results of the proposed method. It is concluded that the proposed divergence
measure is effective for solving real-world problems related to MADM and pattern recognition.
Hubungan pola asuh orang tua dengan kemandirian anak
Authors: Lestari Mira
Published: February 2020

Penelitian ini bertujuan untuk mengetahui hubungan pola asuh orang tua dengan kemandirian anak kelompok B di gugus VIII Kasihan, Bantul. Penelitian ini merupakan penelitian kuantitatif dengan metode korelasi. Populasi penelitian ini adalah anak kelompok B di gugus VIII Kasihan. Teknik sampling yang digunakan adalah random sampling dengan jumlah 106 anak. Metode pengumpulan data menggunakan kuesioner dan lembar observasi. Metode analisis yang digunakan yaitu analisis diskriptif dan analisis statisik nonparametik dengan teknik chi square. Berdasarkan hasil penelitian diperoleh sebanyak 34,9% anak memiliki tingkat kemandirian rendah dan 65,1% memiliki tingkat kemandirian tinggi. Sebanyak 15,1% orang tua menggunakan pola asuh autoritarian dan 84,9% menggunakan pola asuh autoritative. Pola asuh dengan kemandirian anak memiliki hubungan yang signifikan dengan nilai X2 sebesar 11,335. Pola asuh autoritaive memiliki kontribusi lebih dalam menumbuhkan kamendirian anak daripada pola asuh autoritarian. AbstractThe objective of this study is to determine relationship of parenting with independence of children in gruob B at gugus VIII Kasihan, Bantul. This study a quantitative research with correlation method. The pupulation of this study were children in groub B at gugus VIII Kasihan.. The sampling technique used was random sampling with total of 106 children. Methods of collecting data using questionnaries and observation sheets. The analytical methods used is descriptive analysis and nonparametic static analysis with the chi square technique. Based on the results of the study, 34,9 % of children had a low level of independence and 65,1% high. A total of 15,1% of parents use authoritarian parenting and 84,9% of parents use democratic parenting. Parenting with the independance of children has a significant relationship with the resuls X2 of 11,335. Authoritative parenting have more contributes to develop children independence than authoritarian parenting.
Utilization of indonesian megabiodiversity for integrated science learning with nationalism values to develop concepts understanding and soft security among students of border areas
Authors: Sukardiyono Sukardiyono , Rosana Dadan
Published: February 2020

This research aimed at (1) producing Subject Specific Pedagogic (SSP) of integrated science learning with  nationalism values by utilizing Indonesian megabiodiversity which is valid and practical for the students of border areas, (2) obtaining empirical test results on the effectiveness of SSP integrated science learning with  nationalism values by utilizing Indonesian megabiodiversity to improve the quality of students’ learning outcomes and soft security in border area. The SSP was prepared through a research design referring to  "Prototypal Studies" as put forward by Akker (1999) and Plomp (2001). The important thing that needs to be considered in the development research is the quality of the produced learning tools (product). Plomp (2001) has pointed out the product quality criteria, namely: valid (reflects state-of-the-art knowledge and internal consistency), added value, practical, and effective. This research is intended to solve the problems of junior high schools in the region of (1) Atambua, Belu Regency, East Nusa Tenggara Province, and (2) Entikong, Sanggau Regency, West Kalimantan Province. The reserach results showed that SSP science learning integrating Indonesian megabiodiversity utilization with nationalism values was valid, practical and effective to develop concepts understanding and soft security among students in border areas schools.
The Different Effect of PBL, Inquiry, and DI on the Problem-Solving Skill in Science
Authors: Tyas Rina Ning , Mundilarto Mundilarto
Published: February 2020

The purposes of this study were: (1) to analyze the different effect of PBL, inquiry, and DI on the problem-solving skill in science of the students; (2) to analyze the different effect of PBL and inquiry on the problem-solving skill in science of the students; (3) to analyze the different effect of PBL and DI on the problem-solving skill in science of the students; and (4) to analyze the different effect of inquiry and DI on the problem solving skill in science of the students. This research was a quasi-experiment with the problem-solving skill as the dependent variable, learning model (PBL, inquiry learning, and DI) as the independent variable, and prior knowledge as the covariance variable. The population of this research was grade VIII students of SMP N 1 Batang and the sample was three groups established using the cluster random sampling technique. The results of this study showed: (1) there is a different effect of PBL, inquiry, and DI on the problem-solving skill in science of the students; (2) there is no different effect of PBL and inquiry on the problem-solving skill in science of the students; (3) there is a different effect of PBL and DI on the problem solving skill in science of the students; and (4) there is a different effect of inquiry and DI on the problem solving skill in science of the students.
THE NATURAL ENVIRONMENT AS A LEARNING SOURCE FOR SCIENCE: IMPLEMENTATION STRATEGY
Authors: Wibowo Widodo Setiyo
Published: February 2020

Science is closely related to nature, so the natural environment is one of the most important sources of learning both as means and an object. The particular study aimed to discuss the strategy of using and implementing the natural environment as a learning source for science in junior high schools. The results found out that the use of the natural environment as a learning source for science can be pursued through fieldwork, bringing the environment into the classroom, or also making the school science parks. Using the natural environment as a learning source for science requires careful preparation and planning from the teacher. The learning implementation performed in 3 main stages; preparation, implementation, and follow-up. Through the proper implementation of these stages, various benefits achieved either for students or teachers.
THE EFFECT OF MODIFIED FREE INQUIRY APPROACH ON STUDENT’S PROCESS SKILL AND SCIENCE ATTITUDES
Authors: Kholilurrohman Kholilurrohman , Suryadarma I Gusti Putu
Published: February 2020

This study aims to determine the effect of Modified Free Inquiry approach on student’s process skill, and student science attitudes. This Quasi-Experimental study used pretest-posttest with nonequivalent control group design with grade XI student’s of MAN Maguwoharjo Yogyakarta in the second semester of academic year 2012/2013 as a population, and used 2 classes of XI Science Programs as a sample group. This approach is implemented on biology learning through human sense system matters. Learning in this study lasted for 6 times meetings for each group of samples, and the data were obtained by data collection instruments in the forms of a written multiple choice test for science process skill, observation sheets for scientific process skills and science attitudes, and a questionnaire for science attitudes which was administered before and after learning. The data were processed with IBM SPSS 20 software for windows, and hypothesis testing was done through multivariate analysis. The results of the study show a significant value of 0.000, which mean there are significant effect of Modified Free Inquiry approach on: (1) Student’s science process skill, and (2) science attitudes, if it’s compared with Guided Inquiry approach.
Cultural semiotic in Dayak's Babalai ceremonial at Paramasan as an form of maintaining Dayak language
Authors: Ramadania Fajarika , Arifin Johan
Published: February 2020

This research is entitled "Cultural Semiotic in Dayak’s Babalai ceremonial at Paramasan as a form of maintaining traditional language". This research has long-term goal of introducing Dayak Language in general and Dayak language culture, in particular, to attract tourists to visit Paramasan, Banjar District of South Kalimantan. This research identifies, analyzes, and interprets cultural symbol which sourced from Dayak tribe mantra during Babalai ceremony. The cultural symbols to be identified are the symbols based on Pierce's trilogy of indexes, icons, and symbols. This study aims to describe the Dayak tribe mantra used in Babalai ceremonial and to analyze symbols in the Meratus Dayak’s tribe mantra used during Babalai event in Paramasan, Banjar district of South Kalimantan. Each symbol and icon used in each culture contains its own cultural values that are considered significant in its community. The study of Dayak’s Meratus mantra text would enrich the treasury of language and culture in local-global communities and could strengthen solidarity among nations and countries. The language used as a medium in expressing or expression is a media to know historical evidence as the context of an understanding of the identity of a culture. Cultural identity emerges within a community not only as a color of locality but also as a cultural expression that offers an alternative image in society.
Nilai dan etika pekerjaan sosial di dalam konseling hipnoterapi
Authors: Rohimi Rohimi
Published: February 2020

Dalam penelitian ini mengkaji tentang pelayanan konseling terapi (teraphy counseling) dalam praktik hipnoterapis di lembaga Ikatan Hipnoterapis Indonesia (IHI) Yogyakarta, dengan fokus penelitian bagaimanakah model pelayanan konseling Hipnoterapis dan bagaimakah nilai dan etika pekerjaan sosial terhadap klien di lembaga Ikatan Hipnoterapis Indonesia (IHI) Yogyakarta. Dan penelitian ini dilakukan dengan penelitian lapangan (field research), dengan tujuan untuk mendapatkan data yang lebih actual dengan metode wawancara. Dalam penelitian ini, peneliti mendapat pemahaman baru terkait dengan ilmu hypnosis atau hipnoterapi ini, karena dari hasil penelitian dalam konseling hipnoterapis, seorang pekerja sosial lebih fokus pada terapi perorangan (Casework teraphy) yang bertujuan untuk memberikan penyembuhan kepada klien yang mengalami masalah mental atau psikolognya. Di lembaga lkatan Hipnoterapi Indonesia (IHI) Yogyakarta, telah menangani klien dan penyembuhan kepada klien dengan permasalahan yang sangat variatif. Seingga dimana cara pelayanannya melalui metode hipnotis, sehingga pada tahap ini, seorang terapis atau pekerjaan sosial benar-benar membawa kode etiknya di saat memberikan pelayanan, untuk menjaga martabat profesionalitasnya.
Keefektifan model PBL, PJBL, dan inquiry pendekatan saintifik untuk meningkatkan hasil belajar IPS SMP
Authors: Septianoko Riko , Siasah M Muhsinatun
Published: February 2020

Penelitian ini bertujuan untuk mengetahui: (1) perbedaaan hasil belajar IPS antara siswa yang belajar dengan model Problem Based Learning, Project Based Learning, dan Inquiry; (2) hasil belajar siswa yang belajar dengan model Inquiry dengan model Problem Based Learning; (3) hasil belajar siswa yang belajar dengan model Problem Based Learning dengan model Project Based Learning; (4) hasil belajar siswa yang belajar dengan model Inquiry dengan model Project Based Learning. Populasi Penelitian adalah siswa SMP di Kabupaten Bantul dengan sampel SMP Negeri 1 Imogiri, SMP Negeri 1 Sewon, dan SMP Negeri 3 Bantul, dipilih secara Purposive Random Sampling. Teknik pengumpulan data menggunakan tes yang diuji dengan validitas isi dan validitas konstruk. Normalitas data diuji dengan rumus Kolmogorof-Smirnov, dan homogenitas diuji dengan Levene-Test. Teknik analisis data hasil penelitian menggunakan One way Anova. Hasil penelitian: (1) terdapat perbedaan hasil belajar antara model Problem Based learning, Project Based Learning, dan Inquiry (2) hasil belajar siswa dengan model Inquiry lebih tinggi dibandingkan dengan model Problem Based Learning (3) hasil belajar siswa dengan model Problem Based Leaning lebih tinggi dibandingkan dengan model Project Based Learning (4) Hasil belajar siswa yang belajar dengan model Inquiry lebih tinggi dibandingkan model Project Based Learning.
Models and a Tecnique for Determining the Speech Activity of a User of a Socio-Cyberphysical System
Authors: Usina E. E. , Shabanova A. R. , Lebedev I. V.
Published: February 2020

Purpose of reseach. The article presents the development of the model-algorithmic support for the process of determining the speech activity of a user of a socio-cyberphysical system. A topological model of a distributed subsystem of audio recordings implemented in limited physical spaces (rooms) is proposed; the model makes it possible to assess the quality of perceived audio signals for the case of distribution of microphones in such a room. Based on this model, a technique for determining the speech activity of a user of a socio-cyberphysical system, which maximizes the quality of perceived audio signals when a user moves in a room by means of determining the installation coordinates of microphones has been developed.

Methods. The mathematical tools of graph theory and set theory was used for the most complete analysis and formal description of the distributed subsystem of the audiorecording. In order to determine the coordinates of the placement of microphones in one room, a relevant technique was developed; it involves performing such operations as emitting a speech signal in a room using acoustic equipment and measuring signal levels using a noise meter in the places intended for installing microphones. 

Results. The dependences of the correlation coefficient of the combined signal and the initial test signal on the distance to the signal source were calculated for a different number of microphones. The obtained dependences allow us to determine the minimum required number of spaced microphones to ensure high-quality recording of the user’s speech. The results of testing the developed technique for determining speech activity in a particular room indicate the possibility and high efficiency of determining the speech activity of a user of a socio-cyberphysical system.

Conclusion. Application of the proposed technique for determining the speech activity of a user of a sociocyberphysical system will improve the recording quality of the audio signal and, as a consequence, its subsequent processing, taking into account the possible movement of a user.
Study of the Effectiveness of the Application of Information Technology in the Technosphere Safety Management System
Authors: Popov V. M. , Yushin V. V. , Iordanova A. V. , Trifonov A. P.
Published: February 2020

Purpose of research. The purpose of this study is to assess the potential of applying information technology, in particular mobile multifunction devices, as an additional type of control of harmful production factors in the field of labour protection.

Methods. One of the main techniques used in this study is an experiment involving laboratory measurements of the level of artificially created production noise using a mobile multifunction device (smartphone) with pre-installed utilities and a calibrated device ‒ noise meter, and subsequent comparison of the results. The measurements were carried out in accordance with the methodological guidelines developed specially for mobile multifunction devices (MMFDs) by the authors. 

Results. An analysis of the results obtained made it possible to assess the possibility of applying mobile multifunction devices in monitoring harmful factors in the work environment. While conducting the research, it was found that it is possible to use MMFDs in the occupational safety management system of the enterprise, since the deviations of the obtained values from the values of the calibrated noise meter adopted as the standard are insignificant. According to the results of the study, a flow diagram for the use of mobile multifunctional devices in occupational safety management systems of  an enterprise was developed. 

Conclusion. Thus, the use of MMFDs as an additional means of controlling the parameters of the production environment from the theoretical point of view is possible. It should be noted that in practice, application of MMFDs in the occupational safety management system will be challenging from legal and methodological viewpoints. The most basic problem is that MMFDs are not registered in the State Register of Measuring Equipment as measuring tools, which does not allow the official use of the data obtained. However, application of mobile multifunctional devices in the field of labour protection will ensure rapid collection of information on changes in indicators of harmful factors in the work environment, and as a result, will make it possible to quickly respond to these changes, which will significantly reduce the risk of accidents and occupational diseases.
Optimization of Analog-Discrete Conversions of the Input Action in the Subsystem of the Receiving Channel of the Information-Measuring System
Authors: Burmaka A. A. , Govorukhina T. N. , Goryainov R. Y.
Published: February 2020

Perpose of research is to develop a technique for developing system and local models of targeted processes of functioning of the subsystem of the receiving channel of an information-measuring system. These models should make it possible to substantiate the possibility of optimizing the processes of interaction of the components of the analog-discrete conversion of the input action of a random nature.

Methods. The technique for obtaining measurement information in the information-measuring system involves the use of algorithms that minimize information loss at each stage of conversion of the input action. A possible approach is the use of rational and optimal solutions when selecting and substantiating functional support of the input action ),,( St  in order to obtain current measurement information while minimizing residual uncertainty.

Results. To solve this problem, it is necessary to build a system model for the totality of the basic functions that determine the implementation of the targeted process of analog-discrete conversion ) ,,( S t  ; to substantiate the way these functions are implemented, the criteria for their interaction; to determine the optimization technique and (or) rational construction of local targeted processes; to prepare guidelines and rules for structural constructions of the subsystem of the information-measuring system, the input actions of which have priori unknown characteristics. The paper proposes an approach to the functional organization of analog-discrete conversions of the input action of a random nature in the receiving channel subsystem of an information-measuring system, which allows improving the quality of the receiving channel of the information-measuring system and the operation of its components by optimizing the interrelated targeted processes for detecting pulse signals and measuring their parameters against the background of noise with a priori unknown characteristics.

Conclusion. The application of procedures for temporary selection of signals controlled by the detection channel allows increasing the speed and accuracy of determining their parameters, increasing the noise immunity of the receiving channel subsystem of the information-measuring system, reducing the probability of skipping weak signals as well as increasing the accuracy of measuring the temporal parameters of pulse signals.