bluuebunny/crossref_metadata_2025 huggingface dataset:
Socioecological factors influencing the risk of developing hypertensive disorders of pregnancy in India: a rapid review
Authors: Alur Anumita , Phipps Jennifer E. , Simmons Leigh Ann
Published: October 2024

Background

The prevalence of hypertensive disorders of pregnancy (HDPs) in India is 11%, which is one of the highest rates globally. Existing research on HDPs in India primarily focuses on biological risk factors, with minimal research on how socioecological factors combine to increase risk of HDPs. We conducted a rapid review using Bronfenbrenner’s Ecological Model to understand the social and cultural factors associated with HDPs among Indian pregnant women to identify possible intervention targets that may uniquely improve health in this population. Bronfenbrenner’s Ecological Model is a framework that can be used to understand the complex relationship between multiple influences on health.

Methods

We reviewed studies published between January 2010 and January 2024 using PubMed, Science Direct, and Scopus databases. Search terms included variants of hypertension, pregnancy, and India. Inclusion criteria were: (1) peer-reviewed journal article; (2) published between January 2010 to January 2024; (3) participants consisted of Indian women living in India; (4) studies evaluated socioecological risk factors associated with HDPs. One independent reviewer performed searches, screening, data extraction, and quality assessment. Each included study was then organized within Bronfenbrenner’s Ecological Model.

Results

A total of 921 studies were generated from the initial search, with 157 exclusions due to duplicates. Following screening for inclusion and exclusion criteria at the title/abstract and full text levels, 17 studies remained in the final review. Socioecological risk factors of HDPs were identified at each level, with the most commonly identified influences including: low socioeconomic status (SES), lacking community education and knowledge on HDP management and prevention, and lacking prenatal HDP screening.

Conclusion

This study determined that the high risk for HDPs in India is influenced by many intertwined socioecological factors. Women in rural and low SES areas need more health education on HDP management and prevention. There also needs to be more adequate prenatal HDP screening, with at least 4 and ideally 8 prenatal visits. Prenatal screenings should be accompanied with culturally appropriate patient education, especially for low SES women who have limited literacy, so that they can effectively make individual and microsystemic lifestyle decisions aimed at either managing or preventing HDPs.
Health, economic and social impacts of the Brazilian cash transfer program on the lives of its beneficiaries: a scoping review
Authors: Magalhães Júlia , Ziebold Carolina , Evans-Lacko Sara , Matijasevich Alicia , Paula Cristiane Silvestre
Published: October 2024

Background

The Bolsa Família cash transfer Program (BFP) aims to break the poverty cycle by providing a minimum income to poor families conditioned on their investment in human capital (such as, education and health) and currently is the largest Program in the world in terms of the number of beneficiaries. Because there is a scarcity of reviews grouping studies on the impacts of the BFP, the objective of this scoping review was to identify and describe studies which evaluate the impact of the BFP on poverty, health, education, and other related outcomes.

Methods

We searched for quantitative, qualitative, and mixed-method articles that assessed the impact of the BFP on any aspect of the beneficiaries' lives between 2003 and March 2021. We included quantitative articles that used experimental, quasi-experimental or pre and post comparison designs. We excluded articles that analyzed impacts on political outcomes. There was no age restriction for the participants. The search was done in seven electronic databases.

Results

One thousand five hundred forty-six papers were identified and 94 fulfilled the inclusion criteria. Poverty and health outcomes were the most common outcomes studied. We found consistent evidence of the positive impact of the BFP on poverty reduction, as well as employment outcomes. We also found positive impacts in relation to mortality rates for children and adults, school dropout and school attendance among children and adolescents, and violence related outcomes such as homicide, suicide, crime, and hospitalization. However, we also found some evidence that BFP increased intimate partner violence and gender stereotypes among women and no evidence of impact on teenage pregnancy.

Conclusions

Overall, the studies included found that BFP showed positive impacts on most poverty, health and education outcomes. More studies are needed to confirm some results, especially about violence and stereotype against women as there were few evaluations on these outcomes.
Reliability assessment of the ‘field audit for children’s active transport routes to school’ (FACTS) tool
Authors: Vasey Thomas V. , Dale Michael J. , Carroll Suzanne J.
Published: October 2024

Background

Children’s active travel to school is associated with physical activity and thus health. Safe Routes to School (SR2S) programs identify ‘safe routes’ to promote children’s active travel to school. No field audit tool exists specifically to assess the microscale built environment of these ‘safe routes’ within Australia. This study describes the reliability assessment of the Field Audit for Children’s Active Transport to School (FACTS) tool.

Methods

The FACTS tool was developed using a multi-step process, including a literature search, expert opinion, and pilot testing. For the reliability assessment, two trained auditors collected data at eight schools over three weeks in April 2021. For inter-rater reliability, auditors conducted audits on the ‘safe routes’ for the same six schools. For intra-rater reliability, auditors conducted repeat measures on the ‘safe routes’ for four schools each (eight schools total), including three different schools each from the six used for inter-rater reliability and one additional school. Item-by-item reliability was assessed using Cohen’s Kappa, Cohen’s Weighted Kappa, and percentage agreement. The reliability of calculated domain scores was assessed using intraclass correlation coefficients.

Results

For inter-rater reliability, 31 of the 45 (68.9%) items had moderate to almost perfect agreement, seven items (15.6%) had below moderate agreement, and a Kappa statistic could not be calculated for seven items (15.6%) due to constant values. For intra-rater reliability, 37 of the 45 (82.2%) items had moderate to almost perfect agreement, two items (4.4%) had below moderate agreement, and a Kappa statistic could not be calculated for six items (13.3%) due to constant values. For inter- and intra-rater reliability of the segment domain scores, three of the four domains had substantial to almost perfect agreement. For inter- and intra-rater reliability of the crossing domain scores, all four domains had moderate to almost perfect agreement. For inter- and intra-rater reliability of the segment, crossing, route, and school scores, all had substantial to perfect agreement.

Conclusions

The FACTS tool can reliably characterise the microscale built environment of promoted ‘safe routes’ for their use within SR2S programs, and should be considered for use in future SR2S programs within the suburban Australian context.
Exploring the effects of COVID-19 outbreak control policies on services offered to people experiencing homelessness
Authors: Davis Alexa J. , Halperin Donna M. , Condran Brian R. , Kervin Melissa S. , Di Castri Antonia M. , Salter Katherine L. , Bettinger Julie A. , Parsons Janet A. , Halperin Scott A.
Published: October 2024

Background

The COVID-19 pandemic and subsequent implementation of public health policies exacerbated multiple intersecting systemic inequities, including homelessness. Housing is a key social determinant of health that played a significant part in the front-line defence against COVID-19, posing challenges for service providers working with people experiencing homelessness (PEH). Public health practitioners and not-for-profit organizations (NFPs) had to adapt existing COVID-19 policies and implement novel measures to prevent the spread of disease within congregate settings, including shelters. It is essential to share the perspectives of service providers working with PEH and their experiences implementing policies to prepare for future public health emergencies and prevent service disruptions.

Methods

In this qualitative case study, we explored how service providers in the non-profit sector interpreted, conceptualized, and implemented COVID-19 public health outbreak control policies in Nova Scotia. We interviewed 11 service providers between September and December 2020. Using thematic analysis, we identified patterns and generated themes. Local, provincial, and national policy documents were useful to situate our findings within the first year of the COVID-19 pandemic and contextualize participants’ experiences.

Results

Implementing policies in the context of homelessness was difficult for service providers, leading to creative temporary solutions, including pop-up shelters, a dedicated housing isolation phone line, comfort stations, and harm reduction initiatives, among others. There were distinct rural challenges to navigating the pandemic, which stemmed from technology limitations, lack of public transportation, and service closures. This case study illustrates the importance of flexible and context-specific policies required to support PEH and mitigate the personal and professional impact on service providers amid a public health emergency. Innovative services and public health collaboration also exemplified the ability to enhance housing services beyond the pandemic.

Conclusions

The results of this project may inform context-specific emergency preparedness and response plans for COVID-19, future public health emergencies, and ongoing housing crises.
Patient perceptions of an electronic-health-record-based rheumatoid arthritis outcomes dashboard: a mixed-methods study
Authors: Nasrallah Catherine , Wilson Cherish , Hamblin Alicia , Hariz Christine , Young Cammie , Li Jing , Yazdany Jinoos , Schmajuk Gabriela
Published: October 2024

Background

Outcome measures are crucial to support a treat-to-target approach to rheumatoid arthritis (RA) care, yet their integration into clinical practice remains inconsistent. We developed an Electronic Heath Record-integrated, patient-facing side-car application to display RA outcomes (disease activity, functional status, pain scores), medications, and lab results during clinical visits (“RA PRO Dashboard”). The study aimed to evaluate patient perceptions and attitudes towards the implementation of a novel patient-facing dashboard during clinical visits using a mixed-methods approach.

Methods

RA patients whose clinicians used the dashboard at least once during their clinical visit were invited to complete a survey regarding its usefulness in care. We also conducted semi-structured interviews with a subset of patients to assess their perceptions of the dashboard. The interviews were transcribed verbatim and analyzed thematically using deductive and inductive techniques. Emerging themes and subthemes were organized into four domains of the Ecological Model of Health.

Results

Out of 173 survey respondents, 79% were interested in seeing the dashboard again at a future visit, 71% felt it improved their understanding of their disease, and 65% believed it helped with decision-making about their RA care. Many patients reported that the dashboard helped them discuss their RA symptoms (76%) and medications (72%) with their clinician. Interviews with 29 RA patients revealed 10 key themes: the dashboard was perceived as a valuable visual tool that improved patients’ understanding of RA outcome measures, enhanced their involvement in care, and increased their trust in clinicians and the clinic. Common reported limitations included concerns about reliability of RA outcome questionnaires for some RA patients and inconsistent collection and explanation of these measures by clinicians.

Conclusions

In both the quantitative and qualitative components of the study, patients reported that the dashboard improved their understanding of their RA, enhanced patient-clinician communication, supported shared decision-making, and increased patient engagement in care. These findings support the use of dashboards or similar data visualization tools in RA care and can be used in future interventions to address challenges in data collection and patient education.
Leading with AI in critical care nursing: challenges, opportunities, and the human factor
Authors: Hassan Eman Arafa , El-Ashry Ayman Mohamed
Published: October 2024

Introduction

The integration of artificial intelligence (AI) in intensive care units (ICUs) presents both opportunities and challenges for critical care nurses. This study delves into the human factor, exploring how nurses with leadership roles perceive the impact of AI on their professional practice.

Objective

To investigate how nurses perceive the impact of AI on their professional identity, ethical considerations surrounding its use, and the shared meanings they attribute to trust, collaboration, and communication when working with AI systems.

Methods

An interpretive phenomenological analysis was used to capture the lived experiences of critical care nurses leading with AI. Ten nurses with leadership roles in various ICU specializations were interviewed through purposive sampling. Semi-structured interviews explored nurses’ experiences with AI, challenges, and opportunities. Thematic analysis identified recurring themes related to the human factor in leading with AI.

Findings

Thematic analysis revealed two key themes which are leading with AI: making sense of challenges and opportunities and the human factor in leading with AI. The two main themes have six subthemes which revealed that AI offered benefits like task automation, but concerns existed about overreliance and the need for ongoing training. New challenges emerged, including adapting to new workflows and managing potential bias. Clear communication and collaboration were crucial for successful AI integration. Building trust in AI hinged on transparency, and collaboration allowed nurses to focus on human-centered care while AI supported data analysis. Ethical considerations included maintaining patient autonomy and ensuring accountability in AI-driven decisions.

Conclusion

While AI presents opportunities for automation and data analysis, successful integration hinges on addressing concerns about overreliance, workflow adaptation, and potential bias. Building trust and fostering collaboration are fundamentals for AI integration. Transparency in AI systems allows nurses to confidently delegate tasks, while collaboration empowers them to focus on human-centered care with AI support. Ultimately, dealing with the ethical concerns of AI in ICU care requires prioritizing patient autonomy and ensuring accountability in AI-driven decisions.
Conceptual framework for the health and well-being of caregivers of HIV/AIDS orphans in North West Province, South Africa
Authors: Molato Boitumelo Joy , Moloko-Phiri Salaminah , Koen Magdalena , Matsipane Molekodi
Published: October 2024

Background

The human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) is an epidemic that continues to increase the burden of care among caregivers of HIV/AIDS orphans. Research has confirmed that HIV/AIDS orphans’ caregivers perform their duties in an unconducive environment. Consequently, this negatively impacts their health leading to inability to discharge caregiving duties effectively. After carefully considering the caregivers’ predicament, the researchers found it imperative to develop a conceptual framework for the North West Province as this province lacks a conceptual framework that addresses the health and well-being of caregivers for orphaned children.

Methods

An exploratory, descriptive and contextual design was used in the study. The population for this study were HIV/AIDS orphans’ caregivers and ward-based professional nurses who also served as outreach team leaders. Non-probability purposive sampling technique was used to select participants for this study. Data was collected using individual semi-structured interviews, focus groups, and field notes. Six steps of thematic analysis were adopted to analyze collected data. The practice-orientated theory by Dickoff, James, and Wiedenbach guided the development of the conceptual framework. These six steps include the agent, recipient, context, procedure, dynamics, and terminus.

Results

The study findings include home visits, health education, support during disclosure, routine monitoring of blood and growth, mobilization of support systems and resources, and utilization of government services.

Conclusion

The conceptual framework seeks to improve the health and well-being of HIV/AIDS orphans caregivers so that they may provide high-quality care to the orphans. The framework guides outreach team leaders and nurses registered in primary health care institutions on the procedure to follow to improve and preserve the health of caregivers of children orphaned by HIV/AIDS.
Incidence of periprosthetic joint infection after primary total knee arthroplasty shows significant variation : a synthesis of meta-analysis and bibliometric analysis
Authors: Ma Tao , Jiao Jun , Guo Da-Wei , Lv Shu-Zheng , Zhang Di , Hou De-Cai
Published: October 2024

Total Knee Arthroplasty (TKA) is a surgery that is commonly performed on older adults to improve their quality of life. However, the increasing use of knee joint prostheses has led to a rise in the incidence of Prosthetic Joint Infections (PJI) in patients after TKA. Different clinical studies have looked at the occurrence of PJI after TKA in different regions, but they have drawn varying conclusions. To better understand this topic, we conducted a meta-analysis and bibliometric study using data from multiple databases. Our research found that the estimated prevalence of PJI after TKA is approximately 1.08% across different regions, but there is still considerable variation. Additionally, our regression analysis of sub-groups shows significant differences in follow-up periods. Furthermore, our comprehensive bibliometric analysis identifies current research trends, “hotspots” related to TKA-related PJI, influential nations, organizations, and noteworthy publications. Our analysis provides valuable insights to guide future research in this area.
Ankle syndesmotic ligaments avulsion fractures: incidence in adult population
Authors: Yao Xiang , Wang Chong , Pan Weijie , Chao Yicong , Tang Jilei
Published: October 2024

Background

Distal tibiofibular syndesmosis injury is often associated with ankle fractures in adults. Injuries to the anterior/posterior inferior tibiofibular ligament (AITFL/PITFL) may present as a mid-substance tear or as an avulsion at insertion. Tibial and fibular avulsion of the AITFL is known as Tillaux fracture and Wagstaffe fracture, respectively. Tibial avulsion of the PITFL is referred to as a Volkmann fracture, and fibular avulsion of the PITFL is still undefined and has not been reported yet. The aim of this study is to summarize the incidence of these four avulsions, that is, tibial and fibular avulsions of the AITFL and PITFL.

Method

Radiography and computed tomography (CT) imaging data of all adult patients with ankle fractures treated at our hospital between November 2010 and March 2023 were retrospectively analyzed. All ankle fractures were classified according to the Weber-AO and Lauge-Hansen classification systems by two experienced radiologists and two surgeons. The incidence of the four avulsions of the AITFL/PITFL was determined.

Results

In total, 1,770 ankle fractures in 1,758 patients were included in this study. The total incidence of avulsions at the four insertions of the AITFL/PITFL (occurring at one, two, or three insertions) was found to be 26.3% (465/1,770). Volkmann fracture had the highest incidence (19.9%, 353/1,770), and it was followed by Tillaux fracture (5.3%, 93/1,770), Wagstaffe fracture (3.3%, 59/1,770), and fibular avulsion of the PITFL (0.5%, 8/1,770). It is noteworthy that fibular avulsion of the PITFL has been reported here for the first time. The incidence of avulsion at one insertion was 23.6% (418/1770) and 2.7% (47/1770) at multiple insertions.

Conclusion

In adult ankle fractures, avulsion occurs at the four insertions of the AITFL/PITFL in more than 25% of patients. The tibial insertion of the PITFL had the highest incidence of avulsion among the four insertions, while the fibular insertion of the PITFL had the lowest. The four types of avulsions can be isolated or in association with other avulsions. Future research studies on these four types of avulsion fractures would help in accurate diagnosis, decision-making and treatment of ankle Syndesmosis injuries.

Level of evidence

Level III, retrospective cohort study.
The role of microwave radiation in extractive desulfurization of real diesel fuel for green environment: an experimental and computational investigation
Authors: Mostafa Hamida Y. , Khedr Ghada E. , Mohamed Ard Elshifa M. E. , El-Aty Dina M. Abd
Published: October 2024

The process of removing sulfur compounds and aromatic compounds to produce clean fuel is an important and effective contribution to the processes of mitigating and adapting to climate change. In contrast, it is necessary to find an innovative way to remove sulfur and carcinogenic aromatic compounds because clean, low-sulfur diesel is commonly used in all countries of the world at the present time. Therefore, in this work, we have studied the effect of the microwave radiation power and the irradiation time with the use of more than one type of organic solvent; methanol, acetonitrile and ethyl acetoacetate; as an extractant and solvent to feed ratio impact on the removal of sulfur and aromatic compounds of a real diesel fuel feed which has 450 ppm sulfur content and 16 wt% aromatic Content. The results showed that the best solvent used during this work was ethyl acetoacetate. According to the results, high sulfur removal (≈ 92%) was accomplished with microwave-assisted extractive desulfurization technique under the following ideal conditions: the irradiation time is 7 min, the solvent feed ratio is 3:1 and the microwave intensity is 180 W. To reveal the mechanism of microwave-assisted extractive desulfurization via different organic solvents, a theoretical study including structural examination and interaction energy analysis on the interaction between dibenzothiophene (DBT) or dimethyl dibenzothiophene (DMDBT) and the different organic solvents was also conducted.
Development of molecular diagnostic protocols for simultaneous identification of common bed bugs (Cimex lectularius) and tropical bed bugs (Cimex hemipterus)
Authors: Han Jeong Heum , Choi Junhyeong , Cho Susie , Lee Si Hyeock , Kim Ju Hyeon
Published: October 2024

Background

The resurgence of two bed bug species, the common bed bug (Cimex lectularius Linnaeus, 1758) and tropical bed bug (Cimex hemipterus Fabricius, 1803), in the same geographical regions has been frequently reported recently. Consequently, the rapid identification of these species is crucial for implementing targeted capture traps and tailored pyrethroid resistance diagnosis, due to differences in genetic and physiological traits.

Methods

To develop molecular diagnostic methods, distinct protocols were established for multiplex PCR and loop-mediated isothermal amplification (LAMP) using species-specific primers based on species-specific segments of internal transcribed spacer 2 sequences. These methods were optimized for rapid and accurate identification of the two bed bug species.

Results

Both multiplex PCR and LAMP protocols were effective in simultaneously identifying the two bed bug species, even when utilizing DNA released from dead specimens. Notably, the straightforward procedure and minimal time commitment of LAMP suggest its potential for rapid and accurate diagnosis of bed bugs in the field. The diagnostic accuracy of these methods was validated through a blind test.

Conclusions

The multiplex PCR and LAMP protocols lay the foundation for rapid and accurate field identification of bed bug species, enabling the use of appropriate traps and the detection of species-specific pyrethroid resistance mutations. This approach ensures effective management tailored to the unique characteristics of each bed bug species.

Graphical Abstract
Changes in vaginal cytokines concentrations during artificial insemination and natural service in beef heifers
Authors: McLean Kyle J. , Ault-Seay Taylor B. , Myer Phillip R.
Published: October 2024

Objective

Heifer development is crucial for the optimization of reproductive efficiency in beef production. Heifer development is largely influenced by nutrition. Nutritional status of these heifers can influence immunological responses that are crucial for reproduction. Commercial Angus heifers (n = 9) were utilized, in a pilot study, to elucidate the effects of sampling time (days 0, 7, 14, 21, 28, and 35), pregnancy status, and type of mating on individual cytokine concentrations and cytokine profiles in the vagina following breeding.

Results

Cytokine profiles were analyzed using MetaboAnalyst 5.0 and one-way ANOVAs were performed in R Studio to identify differences in individual cytokines based on sampling time, pregnancy status, and type of mating. Cytokine profiles were different (P = 0.05) 7 days after either mating type. Cytokines, IL-1β, IL-17a, MCP-1, and TNFα were different based on the mating type and pregnancy status. Multiple cytokines, IL-1α, IL-1β, IL-6, IL-8, IL-10, IL-17a, VEGFa, and MIP1α, were different between days regardless of pregnancy status. In conclusion, vaginal cytokines differ based on pregnancy status, type of mating, and time which may be indicative of vital pathways that need to be activated for pregnancy.
Socioeconomic inequalities of pregnancy termination among reproductive age women in Bangladesh: a decomposition analysis using demographic and health survey
Authors: Hossain Md. Aslam , Mujahidul Islam A. M. , Tohan Mortuja Mahamud , Rahman Md. Ashfikur
Published: October 2024

Objectives

Undergoing women of pregnancy termination (PT) significantly faces the problem of physical and mental health. This study aims to assess the prevalence and socioeconomic disparity factors of PT in Bangladesh. This study analyzed data from the 2017–18 Bangladesh Demographic and Health Survey. Researchers employed chi-square tests to identify relationships between categorical variables and logistic regression to pinpoint factors associated with PT. To assess the socioeconomic variation of PT, the analysis utilized concentration curves, concentration indices, and decomposition techniques.

Results

The study found that 21.0% of reproductive-aged women in Bangladesh had ever terminated a pregnancy. Our study revealed that women from Chittagong and Sylhet regions, with wealthier backgrounds, aged 30 or older, employed in business, taking short birth intervals, and whose husband/partner was 35 or older, were more likely to have had a pregnancy termination with statistical significance (p < 0.05). Besides, concentration curves showed a higher prevalence of PT among wealthier women (CCI = 0.029, p < 0.001). Decomposition of this inequality revealed that a woman’s wealth status was the largest contributor (74.98%) to the observed disparities, followed by exposure to mass media (41.82%), place of residence (34.35%), occupation (24.81%), and preceding birth interval (6.53%). Our study recommended that, in mitigating the above disparities, we should foster open discussions about underlying factors contributing to PT in Bangladesh.
Oral immunotherapy improves the quality of life of adults with food allergy
Authors: Epstein-Rigbi Na’ama , Levy Michael B. , Nachshon Liat , Koren Yael , Goldberg Michael R. , Elizur Arnon
Published: October 2024

Background

Oral immunotherapy (OIT) has become the standard of care for children with food allergy (FA) and has substantially improved their quality of life. The effect of OIT on the quality of life in adults, however, has been studied to a much lesser degree.

Methods

Patients with food allergy aged ≥ 18 years who underwent OIT at Shamir Medical Center completed the Food Allergy Quality of Life Questionnaire-Adult Form (FAQLQ-AF) before and at the end of treatment. Adults with FA not undergoing OIT who completed the FAQLQ-AF at 2 time points, served as controls.

Results

A total of 44 adults, median age 23.4 years, who underwent OIT for milk (n = 19), egg (n = 2), peanut (n = 9), sesame (n = 6), and tree nuts (n = 8), and 11 controls were studied. The median OIT starting dose was 23.8 mg protein. 33 patients (75%) reached full desensitization within a median of 10.3 months. The FAQLQ-AF baseline scores were comparable between the study and control groups for all items except for Food Allergy related Health (FAH) item in which the study group had a significantly better score (p = 0.02). At the second time point, the study group had significantly better scores in all items (Allergen Avoidance and Dietary Restrictions (AADR), p = 0.02; and Emotional Impact (EI), Risk of Allergen Exposure (RAE), FAH and the Total Score, p < 0.01). The change in scores for the study group was significantly better, statistically and clinically, in AADR, p = 0.04; EI, p < 0.01; RAE, p = 0.01, and in the total score, p = 0.01.

Conclusions

OIT significantly improves quality of life of adults with FA. This finding adds important support for providing OIT in this population.
Adipose derived or bone-marrow derived mesenchymal stem cell treatment for hyposalivation: protocol for a systematic review and network meta-analysis
Authors: Hansen Joachim , Carlander Amanda-Louise Fenger , Jakobsen Kathrine Kronberg , Grønhøj Christian , von Buchwald Christian
Published: October 2024

Background

Salivary hypofunction leads to debilitating oral symptoms and has major complications for overall quality of life. Two of the most frequent causes of xerostomia are radiotherapy in the head and neck and Sjögren’s syndrome. Only symptomatic treatment is available today. An increasing number of both preclinical and clinical studies have suggested that mesenchymal stem cell (MSC) transplantation treatment can increase the salivary flow rate and ameliorate symptoms of xerostomia. However, both adipose-derived and bone marrow–derived MSCs are used, although they differ in important ways. The primary objective of this study is an indirect comparison of the change in the unstimulated salivary flow rate after intervention between patients treated with adipose-derived or bone marrow–derived MSCs.

Methods

This systematic review and network meta-analysis will search for eligible studies in the MEDLINE, EMBASE, and Cochrane CENTRAL register of Controlled Trials. Eligible studies are as follows: clinical studies including human patients with salivary hypofunction due to either radiotherapy or Sjogren’s syndrome who were subsequently treated with either adipose-derived MSCs or bone marrow–derived MSCs. Studies with no control group will be excluded. The search phrase has been peer-reviewed following the PRESS guidelines. The primary outcome is the change in the unstimulated salivary flow rate after treatment with either adipose-derived or bone marrow–derived MSCs. Secondary outcomes are as follows: change in patient reported outcomes, methods of intervention administration, number of injected MSCs, and safety. Data from included studies will be pooled and compared with a fixed-effects or random effects model dependent on signs of heterogeneity, presented with a forest plot, and indirectly compared with a meta-regression in a network meta-analysis. Risk of bias will be assessed with the tools ROBINS-I or RoB-2 depending on type of study.

Discussion

Both adipose-derived and bone marrow–derived MSCs are used today for experimental treatment of salivary hypofunction in humans as no direct or indirect comparisons have been made. Therefore, an evaluation of the effect of adipose-derived vs bone marrow–derived MSC treatment is needed to support future decision-making on the type of MSC used in a clinical trial.

Systematic review registration

PROSPERO ID CRD42024527183.
Novel insights into the role of immunomodulatory extracellular vesicles in the pathogenesis of liver fibrosis
Authors: Li Jiaxuan , Yuan Yue , Fu Qinggang , Chen Min , Liang Huifang , Chen Xiaoping , Long Xin , Zhang Bixiang , Zhao Jianping , Chen Qian
Published: October 2024

Liver fibrosis, a chronic and long-term disease, can develop into hepatocellular carcinoma (HCC) and ultimately lead to liver failure. Early diagnosis and effective treatment still face significant challenges. Liver inflammation leads to liver fibrosis through continuous activation of hepatic stellate cells (HSCs) and the accumulation of immune cells. Intracellular communication among various immune cells is important for mediating the inflammatory response during fibrogenesis. Extracellular vesicles (EVs), which are lipid bilayer membrane-enclosed particles naturally secreted by cells, make great contributions to cell-cell communication and the transport of bioactive molecules. Nearly all the cells that participate in liver fibrosis release EVs loaded with lipids, proteins, and nucleic acids. EVs from hepatocytes, immune cells and stem cells are involved in mediating the inflammatory microenvironment of liver fibrosis. Recently, an increasing number of extracellular vesicle-based clinical applications have emerged, providing promising cell-free diagnostic and therapeutic tools for liver fibrosis because of their crucial role in immunomodulation during pathogenesis. The advantages of extracellular vesicle-based therapies include stability, biocompatibility, low cytotoxicity, and minimal immunogenicity, which highlight their great potential for drug delivery and specific treatments for liver fibrosis. In this review, we summarize the complex biological functions of EVs in the inflammatory response in the pathogenesis of liver fibrosis and evaluate the potential of EVs in the diagnosis and treatment of liver fibrosis.
Comparative analysis of pre-operative findings and post-operative outcomes in primary and secondary macular holes at a tertiary eye hospital in South India
Authors: Darade Shubham , Kathare Rupal , Choudhary Ayushi , Sehgal Gaurang , Chhablani Jay , Godani Kanika , Yadav Naresh Kumar , Gandhi Priyanka , Hande Prathiba , Mangla Rubble , Prabhu Vishma , Venkatesh Ramesh
Published: October 2024

Purpose

This study aimed to compare demographics, clinical characteristics, and post-surgical outcomes between idiopathic and secondary full-thickness macular holes (MHs).

Methods

A retrospective analysis of 348 eyes from 339 patients treated between June 2017 and December 2023 was conducted. The study included both idiopathic and secondary MHs, excluding cases where surgery was not performed or lacked sufficient follow-up. Demographic data, visual acuity (VA), ocular characteristics, and optical coherence tomography measurements were analyzed.

Results

Idiopathic MHs were identified in 308 eyes (89%), and secondary MHs in 40 eyes (11%). Idiopathic MH patients were older (mean age: 68.26 vs. 60.13 years; p = 0.001) and more commonly female (63% vs. 40%; p = 0.005). Post-surgical closure was achieved in 86% of all MHs, with a median VA improvement of 15 ETDRS letters (3 Snellen lines). However, secondary MHs had a lower closure rate (67% vs. 89%, p = 0.001) and less VA improvement (2 lines vs. 3 lines, p = 0.001) compared to idiopathic MHs. Significant differences in maximal basal diameter and diameter hole index were noted between the groups.

Conclusions

Secondary MHs, accounting for 11% of surgical cases, show poorer anatomical and visual outcomes than idiopathic MHs. Despite lower success rates, early surgical intervention in secondary MHs is recommended to enhance outcomes. Differentiating between idiopathic and secondary MHs is crucial for optimal management.
Association of volatile substance, nitrous oxide and alkyl nitrate use with mental health in UK adolescents
Authors: Hawkins Jemma , Hines Lindsey A. , Bonell Chris , Hickman Matthew , Adara Linda , Townson Julia , Cannings-John Rebecca , Moore Laurence , White James
Published: October 2024

Background

‘Inhalants’ have been associated with poorer mental health in adolescence, but little is known of associations with specific types of inhalants.

Aims

We aimed to investigate associations of using volatile substances, nitrous oxide and alkyl nitrates with mental health problems in adolescence.

Method

We conducted a cross-sectional analysis using data from 13- to 14-year-old adolescents across England and Wales collected between September 2019 and March 2020. Multilevel logistic regression examined associations between lifetime use of volatile substances, nitrous oxide and alkyl nitrates with self-reported symptoms of probable depression, anxiety, conduct disorder and auditory hallucinations.

Results

Of the 6672 adolescents in the study, 5.1% reported use of nitrous oxide, 4.9% volatile solvents and 0.1% alkyl nitrates. After accounting for multiple testing, adolescents who had used volatile solvents were significantly more likely to report probable depressive (odds ratio = 4.59, 95% CI 3.58, 5.88), anxiety (odds ratio = 3.47, 95% CI 2.72, 4.43) or conduct disorder (odds ratio = 7.52, 95% CI 5.80, 9.76) and auditory hallucinations (odds ratio = 5.35, 95% CI 4.00, 7.17) than those who had not. Nitrous oxide use was significantly associated with probable depression and conduct disorder but not anxiety disorder or auditory hallucinations. Alkyl nitrate use was rare and not associated with mental health outcomes. Adjustment for use of other inhalants, tobacco and alcohol resulted in marked attenuation but socioeconomic disadvantage had little effect.

Conclusion

To our knowledge, this study provides the first general population evidence that volatile solvents and nitrous oxide are associated with probable mental health disorders in adolescence. These findings require replication, ideally with prospective designs.
Impaired Suppression of Plasma Lipid Extraction and Its Partitioning Away From Muscle by Insulin in Humans With Obesity
Authors: Katsanos Christos S , Tran Lee , Hoffman Nyssa , Roust Lori R , De Filippis Eleanna , Mandarino Lawrence J , Johnsson Kailin , Belohlavek Marek , Buras Matthew R
Published: October 2024

Context

Humans with obesity and insulin resistance exhibit lipid accumulation in skeletal muscle, but the underlying biological mechanisms responsible for the accumulation of lipid in the muscle of these individuals remain unknown.

Objective

We investigated how plasma insulin modulates the extraction of circulating triglycerides (TGs) and nonesterified fatty acids (NEFAs) from ingested and endogenous origin in the muscle of lean, insulin-sensitive humans (Lean-IS) and contrasted these responses to those in humans with obesity and insulin resistance (Obese-IR).

Methods

The studies were performed in a postprandial state associated with steady-state plasma TG concentrations. The arterio-venous blood sampling technique was employed to determine the extraction of circulating lipids across the forearm muscle before and after insulin infusion. We distinguished the kinetics of TGs and NEFAs from ingested origin from those from endogenous origin across muscle by incorporating stable isotope-labeled triolein in the ingested fat.

Results

Insulin infusion rapidly suppressed the extraction of plasma TGs from endogenous but not ingested origin in the muscle of the Lean-IS, but this response was absent in the muscle of the Obese-IR. Furthermore, in the muscle of the Lean-IS, insulin infusion decreased the extraction of circulating NEFAs from both ingested and endogenous origin; however, this response was absent for NEFAs from ingested origin in the muscle of the Obese-IR subjects.

Conclusion

Partitioning of circulating lipids away from the skeletal muscle when plasma insulin increases during the postprandial period is impaired in humans with obesity and insulin resistance.
CHOICE OF A TEACHING CAREER IN PEDAGOGICAL UNIVERSITY STUDENTS: RELATIONSHIP WITH MOTIVATION AND EXPERI-ENCES IN ACADEMIC ACTIVITY
Authors: Gur'yanova Tat'yana А.
Published: October 2024

Background. The choice of a teaching career by graduates of pedagogical universities is determined by various factors. Among them, intrinsic motivation and experiences in learning activities play a major role. The desire to benefit society is also highly important.Purpose. To study the relations between the preference of a teaching career among students of a pedagogical university to academic motivation and experiences in educational activities.Methodology. The empirical data was collected using psychological questionnaires. The obtained data was processed using correlation and regression analysis.Results. Positive correlations were obtained between the preference for a teaching career and intrinsic academic motivation, pleasure from educational activities, effort and desire to benefit society. It was revealed that the most important factors for choosing a teaching career include students’ meaning of educational and professional activity and lack of academic amotivation.Scope of application of the results. The results of the study can be applied in the field of higher pedagogical education in working with students, as well as in the field of secondary education in working with novice teachers.
IMPLEMENTATION OF AN EDUCATIONAL PROJECT AS A SOCIAL EDUCATION TECHNOLOGY FOR TRAINING BACHELORS IN THE FIELD OF SOCIAL WORK
Authors: Osnovina Tatiana Yu. , Tarasova Nina A.
Published: October 2024

Background. The problem is becoming urgent in the demand for the implementation of educational projects that allows increasing the competence of bachelors in the field of social work as a technology that will eliminate the dissonance with an insufficient number of presented model range of the final product.
Purpose. The purpose of the article is to present the implementation of the educational project model as a technology of pedagogical activity improving the competences of university students which includes the possibility of transforming the final product according to the chosen type of literacy in the context of social education. The subject of the analysis is the design of educational projects. The authors aim to present the experience of implementing an educational project model that proves the success of developing professional skills and meta competencies of students.
Research methodology is based on the experimental search work and the technological level of pedagogical research methodology that consider the pedagogical conditions for implementing the technology of project activities for training bachelor students in the field of social work.
Results. This study has identified the pedagogical conditions that ensure the possibility of developing high and average level competences defined by the Federal State Educational Standard for Bachelors in the field of Social Work through the types of literacy that make up social education. The authors present product evaluation criteria that make it possible to draw conclusions on the formation of declared competencies among the participants.
The results of the experimental search work are presented, which allows to track students’ recognition and understanding of the main theoretical units of the course. The authors justify the use of project activities as a pedagogical technology for improving systematically the professional and meta competences, for consolidating theoretical knowledge and developing skills, for expanding the cognitive capabilities of students and providing opportunities for fulfillment of their creative abilities, etc.
Practical implications. The results of the study can be applied for training bachelors in social sciences, for implementing the idea of lifelong education, for providing conditions of creative self-development and professional self-improvement in solving practical problems of specialists in the field of social work.
DIGITAL TRANSFORMATION TRENDS IN FOREIGN LANGUAGE TRAINING OF STUDENTS OF NON-LINGUISTIC SPECIALTIES
Authors: Semenkina Irina A. , Pavlova Tatyana A. , Mirontseva Svetlana S. , Moiseev Dmitry V.
Published: October 2024

Education refers to the spheres of human activity that are most susceptible to digitalization. Within the framework of this article, the trends of digital transformation of foreign language training of university students of non-linguistic specialties are considered in the context of education 4.0, including digital space, digital technologies, and directions of the organization of educational activities. Longitudinal observations, pedagogical experiments, and analysis of educational data have been used in the research. The results suggest that the use of advanced digital learning technologies contributes to the activation of interaction between professors and students in an electronic educational environment, personalization of the educational process, increased motivation for the independent cognitive activity of students, as well as the formation of a wide range of competencies during foreign language training. Digital technologies in a foreign language(s) training, which are implemented in the educational process of the university and constitute a scientific and methodological foundation in the development and use of all types of digital educational resources, are identified. The expediency of their introduction to foreign language teaching is substantiated. One of the most effective directions of digital transformation is the introduction of virtual reality technologies. The analysis of the current use of VR technologies in the electronic educational environment of the university shows the positive impact of immersive on the cognitive functions of students.