bluuebunny/crossref_metadata_2025 huggingface dataset:
RATIONAL FOR CONTINUING TERLIPRESSIN AFTER ENDOSCOPIC VARICEAL LIGATION IN ACUTE VARICEAL HAEMORRHAGE NEEDS FURTHER EVIDENCE: A PILOT STUDY
Authors: POUDEL Ram Chandra , DHIBAR Deba Prasad , SHARMA Navneet , SHARMA Vishal , TANEJA Sunil , PRAKASH Ajay
Published: April 2022

ABSTRACT Background Variceal hemorrhage (VH) is a medical emergency. Prompt endoscopic variceal ligation (EVL) is therapeutic. Terlipressin is used in VH and continued for 2—5 days even after EVL. As hemostasis is primarily achieved by EVL, the benefit of continuing trelipressin after EVL is unknown. Objective To evaluate the efficacy of continuing terlipressin after EVL to prevent re-bleed and mortality. Methods In this pilot study, after EVL 74 patients of VH were randomized into two treatment groups TG2 & TG5, received terlipressin (1 mg IV bolus q 4 hourly) for 2 days and 5 days respectively and one control group (TG0), received 0.9% normal saline (10 mL IV bolus q 4 hourly) and followed up for 8 weeks. Results A total of 9 (12.6%) patients had re-bleed with maximum 4 (5.6%) patients in TG5 group followed by 3 (4.2%) in TG2 and 2 (2.8%) in TG0 groups (P=0.670). The overall mortality was 15 (21.1%) patients, 6 (8.5%) patients in TG0 group, followed by 5 (7.0%) in TG5 and 4 (5.6%) in TG2 group (P=0.691). Adverse drug reactions were significantly higher in treatment groups with maximum 18 (24.32%) patients in TG5, followed by 8 (10.8%) in TG2 and 2 (2.7%) in TG0 groups (P=0.00). Duration of hospital stay was also significantly higher in treatment group, 6.63 (±0.65) days in TG5 followed by 3.64 (±0.57) in TG2 and 2.40 (±0.50) days in TG0 groups (P=0.00). Conclusion The rational for continuing terlipressin after EVL is doubtful as it didn’t have any benefit for the prevention of re-bleed or mortality; rather it increased the risk of adverse drug reactions and duration of hospital stay. Further randomized clinical trials are encouraged to generate more evidence in support or against continuing terlipressin after EVL.
ANALYSIS OF HEALTHCARE ASSOCIATED AND HOSPITAL ACQUIRED INFECTIONS IN CRITICALLY ILL PATIENTS WITH CIRRHOSIS
Authors: D’OLIVEIRA Ricardo Azevedo Cruz , PEREIRA Lívia Carolina Dourado , CODES Liana , ROCHA Mário de Seixas , BITTENCOURT Paulo Lisboa
Published: April 2022

ABSTRACT Background Bacterial infections occur in 43—59% of cirrhotic patients admitted to the intensive care unit with impact in morbidity and mortality. An increase in the frequency of multidrug-resistant (MDRO) and extensively drug-resistant (XDRO) organisms has been described in bacterial infections in cirrhotic patients with an adverse impact on survival. Objective To characterize community-acquired (CA), healthcare-associated (HCA), and hospital-acquired (HA) infections in cirrhotic patients and their impact in the occurrence of adverse outcomes. Methods This study included all cirrhotic patients admitted in an intensive care unit specialized in liver and gastrointestinal diseases in Brazil between January 2012 and June 2018. Frequency and topography of infections were retrospectively evaluated, as well as the frequency of MDRO and XDRO organisms, and their impact in occurrence of acute kidney injury, hepatorenal syndrome, acute-on-chronic liver failure, sepsis and mortality. Results A total of 374 infections were observed and classified as CA (22%), HCA (34%) and hospital-acquired (44%). Eighty-nine (54%) episodes of hospital-acquired infections were second infections. Spontaneous bacterial peritonitis (32%) and urinary tract infection (23%) were the most common infections. Culture-proven infections were positive in 61% of the cases, mainly gram-negative bacteria (73%). Acute kidney injury, hepatorenal syndrome and sepsis were observed, respectively, in 48%, 15% and 53% of the cases. MDRO and XDRO were seen, respectively, in 35% and 16%, mainly in HCA (48% vs 26% in CA infections, P=0.02) and hospital-acquired (58% vs 26% in CA infections, P=0.0009). Adverse outcomes were more frequently observed in subjects with hospital-acquired infections when compared to HCA and CA infections. Hospital-acquired, HCA and second infections were independently associated with in-hospital mortality. Conclusion Hospital-acquired, HCA and second infections are increasingly associated with either MDRO and/or XDRO and are independent predictors of in-hospital mortality. Their recognition and proper selection of appropriate empiric antibiotic regimens are important measures to reduce in-hospital mortality.
SHOULD ROUTINE LIVER BIOPSY BE CONSIDERED IN BARIATRIC SURGICAL PRACTICE? AN ANALYSIS OF THE LIMITATIONS OF NON-INVASIVE NAFLD MARKERS
Authors: CONCON Matheus Mathedi , GESTIC Martinho Antonio , UTRINI Murillo Pimentel , CHAIM Felipe David Mendonça , CHAIM Elinton Adami , CAZZO Everton
Published: April 2022

ABSTRACT Background Non-invasive markers are useful and practical tools for assessing non-alcoholic fatty liver disease (NAFLD), but liver biopsy remains the gold-standard method. Liver biopsy can be easily obtained on individuals undergoing bariatric surgery, but there is no ultimate evidence on the relationship between costs, risks and benefits of its systematic performance. Objective To compare the diagnostic accuracy of non-invasive methods with liver biopsy for detection and staging of NAFLD in obese individuals undergoing bariatric surgery. Methods This is a cross-sectional, observational and descriptive study which enrolled individuals who underwent bariatric surgery from 2018 through 2019 at a public tertiary university hospital. Ultrasound scan, hepatic steatosis index, Clinical Non-Alcoholic Steatohepatitis Score (C-NASH), hypertension, alanine aminotransferase (ALT) and insulin resistance (HAIR), aspartate aminotransferase (AST) to Platelet Ratio Index (APRI), NAFLD Fibrosis Score (NFS) and body mass index, AST/ALT ratio, and diabetes (BARD) were the methods compared with the histopathological examination of wedge liver biopsies collected during surgery. Results Of 104 individuals analyzed, 91 (87.5%) were female. The mean age was 34.9±9.7 years. There was no biopsy-related morbidity. The respective overall accuracies of each marker analyzed were: ultrasound scan (79.81% for steatosis), hepatic steatosis index (79.81% for steatosis), HAIR (40.23% for steatohepatitis), C-NASH (22.99% for steatohepatitis), APRI (94.23% for advanced fibrosis), NFS (94.23% for advanced fibrosis), and BARD (16.35% for advanced fibrosis). Discussion Given the high prevalence of liver disease within this population, even the most accurate markers did not present enough discretionary power to detect and/or rule out the NAFLD aspects they were designed to assess in comparison with liver biopsy, which is safe and easy to obtain in these patients. Conclusion Wedge liver biopsy during bariatric surgery helps to diagnose and stage NAFLD, presents low risks and acceptable costs; given the limitations of non-invasive methods, it is justifiable and should be considered in bariatric routine.
DIAGNOSIS AND MANAGEMENT OF CHRONIC IDIOPATHIC CONSTIPATION: A NARRATIVE REVIEW FROM A BRAZILIAN EXPERT TASK FORCE
Authors: PASSOS Maria do Carmo Friche , ALVARIZ Ricardo Cerqueira , ANDRÉ Eduardo Antonio , BARBUTI Ricardo Correa , FILLMANN Henrique Sarubbi , MURAD-REGADAS Sthela Maria , REZENDE FILHO Joffre , PERROTTI Marcos , GUEDES Luciana
Published: April 2022

ABSTRACT Background Chronic idiopathic constipation (CIC) is a condition that widely affects the global population, represents relevant healthcare resource utilization and costs, and impacts the individual’s well-being. Objective To review the consensus of expert societies and published guidelines on the diagnosis and treatment of CIC in adults, seeking to assist reasoning and decision-making for medical management of patients with CIC and provide a practical reference material. Methods A Brazilian medical task force searched the scientific literature in the following electronic databases: MEDLINE/PubMed, SciELO, EMBASE and Cochrane, using the following descriptors: chronic constipation, diagnosis, management of chronic constipation. In addition, a review of articles on the mechanism of action, safety, and efficacy of therapeutic options available in Brazil was carried out. Results The diagnostic approach and the understanding of the pathophysiology present in CIC are essential items to indicate the appropriate therapy and to understand the ecosystem of the patient’s needs. Conclusion CIC is a common condition in adults, occurring more frequently in the elderly and in women. Proper management is defined by detailed medical history and physical examination, together with appropriate therapeutics, regardless pharmacological or not, and depending on the best moment of indication. This way, the impact on quality of life is also optimized.
TEAM BASED LEARNING: RELATO DE EXPERIÊNCIA NA DISCIPLINA DE CLÍNICA INTEGRADA NA GRADUAÇÃO EM ODONTOLOGIA
Authors: Costa Sarah Teixeira , Miranda Diogo de Azevedo
Published: April 2022

O presente trabalho tem como objetivo, por meio de um relato de experiência, descrever o planejamento, a execução e o desenvolvimento de conceitos relativos a disciplinas já ministradas no curso de Odontologia, utilizando o TBL como metodologia de ensino. Em um primeiro momento, no cenário de uma sala de aula, os estudantes respondiam individualmente questões selecionadas pelos docentes de provas anteriores do ENADE. Todas as questões escolhidas tinham cunho clínico e interdisciplinar. Após a correção preliminar dos professores, sem divulgação dos resultados, os alunos eram divididos em pequenos grupos, para debater cada uma das questões e respostas que eles elegiam, entrando em consenso para a apresentação de uma única resposta do grupo. A interpretação dos resultados, bem como a comparação das pontuações em grupo e individuais, permitiu inferir que o TBL foi bastante útil ao processo de aprendizagem e na avaliação da formação dos acadêmicos. Os estudantes exercitaram suas habilidades de comunicação, argumentação e convencimento, melhorando sua interação entre pares, com os docentes e desempenho pessoal. Os docentes e discentes conseguiram interagir de forma lúdica, além de entender o nível de assimilação dos conteúdos prévios e sua possível aplicação na disciplina a ser cursada. O entendimento dos professores do grau de conhecimento dos alunos facilitou a seleção dos pacientes a serem atendidos, garantindo excelência técnica e satisfação de toda a cadeia de prestação de serviços
Intelligent Links: AI-Supported Connections between Employers and Colleges
Authors: Robson Robby , Kelsey Elaine , Goel Ashok , Nasir Sazzad , Robson Elliot , Garn Myk , Lisle Matt , Kitchens Jeanne , Rugaber Spencer , Ray Fritz
Published: April 2022

When modernization and other changes demand workforce reskilling, employers often turn to local colleges for training programs. Doing so can be a frustrating experience. HR and talent professionals have difficulty identifying and communicating requirements, especially for new jobs and roles, while college continuing education (CE) and professional development offices have difficulty understanding and responding to company needs. This article describes an NSF Convergence Accelerator project called SkillSync™ in which multiple forms of AI are used to address this specific problem and provide national efforts (e.g., the US Chamber of Commerce Talent Pipeline Management initiative) with skills data and skills alignment services. Skillsync uses variations on the Siamese Multi-depth Transformer-based Hierarchical Encoder (SMITH) and other natural language understanding methods to map job descriptions and course information to skills taxonomies, uses machine-learned models to align skills needs with learning outcomes and training, and incorporates an intelligent coach based on Georgia Tech's Jill Watson “virtual teaching assistant” to answer questions about Skillsync's vocabulary, functionality, and process. This article describes these AI methods, how these methods are used in Skillsync, and the challenges involved.
Walt Whitman's Western Jaunt
Authors: Eitner Walter H.
Published: April 2022

In 1879, when Walt Whitman was sixty, he made a trip to the West—first to Kansas to attend the quarter-centennial celebration of Kansas settlement, then on to Denver and the Rockies. Biographers have only briefly reported this trip, if they have dealt with it at all; here for the first time is a thorough reconstruction of Whitman’s western experience. From his own extensive research in newspapers of the period, as well as from Whitman’s published daybooks and notebooks and his collected correspondence. Walter H. Eitner is able to piece together a well detailed itinerary, and to compare the record of the actual journey with Whitman’s imaginative account in Specimen Days.

This study in part constitutes a criticism of the sections of Specimen Days dealing with the West by examining the ways in which Whitman reordered his experiences to have them support a bardic pose he wished to maintain. For the first time Whitman’s three journalist traveling companions—whom Whitman did not even mention in Specimen Days—are fully on record. This account also shows Whitman very much his own press agent, engaging in a wide range of self-promoting activities such as writing his own interviews and sending back to the press in the East accounts of his whereabouts, his health, and his plans.
Landlord William Scully
Authors: Socolofsky Homer E.
Published: April 2022

William Scully, an Irishman who was a member of the lesser landed gentry, put his life’s energy into the accumulation of high-quality, low-cost land. He carefully husbanded his inheritance, and in 1850 he traveled to the United States and purchased with personal savings more than 8,000 acres in central Illinois. In 1851 he acquired another 30,000 acres of swampy virgin land. He added to his holdings until, by the late nineteenth century, he had amassed almost 225,000 acres of fertile farm land in Illinois, Kansas, Missouri, and Nebraska, and had become an absentee, alien landlord to some 1,500 tenants.

Meanwhile, Scully was involved in lawsuits and violent landlord-tenant confrontations over his Irish holdings, which exceeded 2,000 acres. In one skirmish with his tenants Scully was severely wounded and two of his party were killed. Public remonstrance against Scully’s actions brought his name into notoriety throughout Great Britain.

To handle his huge estate in America, Scully employed agents who were strategically located near his land. He inaugurated formal leasing procedures, insisting on elaborate controls: cash rentals, one-year leases, tenant-owned improvements, and soil conservation measures—all unusual for the time. Agitation against his practices as an absentee landlord in the 1880s and 1890s was widely covered in newspapers of the times. Because Scully used crop liens and court action to protect his rights, he was widely denounced for his disregard for his tenants’ welfare. State legislation designed to limit acquisition and inheritance of land by aliens finally forced Scully to gain American citizenship in 1900, six years before his death.

Homer Socolofsky’s biography of Scully, the product of more than thirty years of research, provides a narrative and analysis of Scully’s activities as an investor in both Ireland and the United States. It is based on numerous archival and newspaper sources never before analyzed in published works, including private business records of the Scully estate, as well as Socolofsky’s interviews with Scully tenants.

Socolofsky traces the acquisitions that led to Scully’s vast wealth, stressing the landlord’s strong will and determination and his unique methods of management. He looks closely at the charges against Scully on both sides of the Atlantic and describes Scully’s court fights and other confrontations with his tenants. Finally, he follows the inheritance of Scully’s multi-million dollar estate from Scully’s death to the present.

Scully’s colorful career provides a unique opportunity for studying the economics and politics of land use in this country during the nineteenth century. This volume moves beyond biography to encompass an important segment of the business and agricultural history of the American Midwest.
Brandeis on Democracy
Authors: Strum Philippa
Published: April 2022

Philippa Strum, our foremost authority on Louis Brandeis, gathers together for the first time a sterling selection from his most provocative and profound writings. A kind of "Portable Brandeis," this book provides a concise and readable guide to the thought of a truly great American.

Brandeis, the Ralph Nader of the early twentieth century, was known as the "People's Attorney" for his continuous crusades on behalf of the public. He spoke before citizens' groups and legislative bodies, wrote articles for popular magazines, put his ideas about industrial democracy in the briefs he submitted as a lawyer and later in the opinions he wrote as a Supreme Court justice (1916-1938), and advised presidents Woodrow Wilson and Franklin Roosevelt.

The problems Brandeis faced and the answers he fashioned could have leaped from today's newspapers: corruption in government, conflicts between majority rule and minority rights, movements to limit free speech and the right to privacy, gender equality, the importance of education, the causes of and possible solutions for poverty, the social costs of excessive political or corporate power, the uneasy relationship between lawyers and the public, efficiency and justice in the workplace, the tension between Federal power and states' autonomy, and the responsibility of citizens to their community.

In all his endeavors, Brandeis emphasized both political and economic democracy, citizen participation, and a balance between rights and responsibilities. As leader of the American Zionist movement from 1914 through the 1930s, he dreamed of a democratic Jewish homeland in Palestine founded on Jeffersonian principles. And there were similar echoes of the Founding Fathers in his campaign against the corporate trusts in the United States.

These selections from Brandeis's speeches, letters to family and colleagues, newspaper interviews, articles, and judicial opinions offer us the essence of Brandeis's genius and allow us to appreciate the range and relevance of his ideas for America today.
Kansas Governors
Authors: Socolofsky Homer E.
Published: April 2022

This one-stop reference work is a governors’ hall of fame—a compendium of information about the 51 men who have held the chief executive post since the opening of the Kansas Territory in 1854.

Using both primary and secondary sources, historian Homer Socolofsky sketches a concise biography of each governor and compares their roles in Kansas history. He also provides comparative election and demographic data, as well as suggestions for additional reading.

Supplementing the text are 93 historic photographs, including each chief executive’s portrait and autograph. Twelve maps and tables depict and compare aspects of the governors’ lives, showing occupational background, birthplace, and residence.

Kansas Governors brings together in a single volume a far more complete treatment of both territorial and state governors—as well as acting governors—than can be found in other biographical dictionaries. It will be a useful tool for Kansas history buffs, and an essential reference for school and public libraries.
The Idea of Democracy in the Modern Era
Authors: Ketcham Ralph
Published: April 2022

Although the last half of the twentieth century has been called the Age of Democracy, the twenty-first has already demonstrated the fragility of its apparent triumph as the dominant form of government throughout the world.

Reassessing the fate of democracy for our time, distinguished political theorist Ralph Ketcham traces the evolution of this idea over the course of four hundred years. He traces democracy's bumpy ride in a book that is both an exercise in the history of ideas and an explication of democratic theory.

Ketcham examines the rationales for democratic government, identifies the fault lines that separate democracy from good government, and suggests ways to strengthen it in order to meet future challenges. Drawing on an encyclopedic command of history and politics, he examines the rationales that have been offered for democratic government over the course of four manifestations of modernity that he identifies in the Western and East Asian world since 1600.

Ketcham first considers the fundamental axioms established by theorists of the Enlightenment—Bacon, Locke, Jefferson—and reflected in America's founding, then moves on to the mostly post-Darwinian critiques by Bentham, Veblen, Dewey, and others that produced theories of the liberal corporate state. He explains late-nineteenth-century Asian responses to democracy as the third manifestation, grounded in Confucian respect for communal and hierarchical norms, followed by late-twentieth-century postmodernist thought that views democratic states as oppressive and seeks to empower marginalized groups.Ketcham critiques the first, second, and fourth modernity rationales for democracy and suggests that the Asian approach may represent a reconciliation of ancient wisdom and modern science better suited to today's world. He advocates a reorientation of democracy that de-emphasizes group or identity politics and restores the wholeness of the civic community, proposing a return to the Jeffersonian universalism—that which informed the founding of the United States-if democracy is to flourish in a fifth manifestation.

The Idea of Democracy in the Modern Era is an erudite, interdisciplinary work of great breadth and complexity that looks to the past in order to reframe the future. With its global overview and comparative insights, it will stimulate discussion of how democracy can survive—and thrive—in the coming era.
A MODIFIED TEST FOR DETERMINING THE FLUIDITY OF DUCTILE CAST IRON
Authors: Žbontar Matic , Petrič Mitja , Mrvar Primož
Published: April 2022

The aim of this experimental work was to design a modified test with which it will be possible to determine the fluidity of ductile cast iron. First, we planned the conceptual verification of the designed experiment, which was done by numerical simulations of the casting processes, followed by rapid mould fabrication using 3D printing. A measurement cell was placed in the mould cavity of the experimental chamber for further investigation of the cooling and solidification during casting. From the matrix of data obtained with the experiment, we defined the fluidity of the ductile iron EN-GJS-500-7. Also, we analysed the mechanical properties of the studied alloy, the microstructure, the chemical composition, and the results of the thermal analysis. In accordance with the expectations and theory from the literature, the fluidity in the experimental sample cast at a higher temperature was better than that cast at a lower temperature. Because of the faster cooling rate at the end of the channel of the experimental casting, the microstructure is fine, moreover, we obtain white solidification, ledeburite in the microstructure of the samples etched with Nital. At lower cooling rates, fewer graphite nodules appear in the microstructure, which are larger, and the portion of ferrite is greater.
INFLUENCE OF HEAT TREATMENT ON THE HIGH-TEMPERATURE OXIDATION BEHAVIOUR OF CHROMIUM-MOLYBDENUM-VANADIUM ALLOYED HOT-WORK TOOL STEEL
Authors: Balaško Tilen , Vončina Maja , Burja Jaka , Medved Jožef
Published: April 2022

The high-temperature oxidation behaviour of chromium-molybdenum-vanadium alloyed hot-work tool steel was investigated. High-temperature oxidation was investigated in two conditions: soft annealed, and quenched and tempered. The samples were oxidised in a chamber furnace and in an instrument for simultaneous thermal analysis, for 100 h in the temperature range between 400 °C and 700 °C. Metallographic analysis (optical and scanning electron microscopy) was performed to study the microstructural changes in the steel and the oxide layer. Oxidation kinetics were analysed by thermogravimetric analysis, and equations were derived from the results. The kinetics can be described by three mathematical functions, namely: exponential, parabolic and cubic. However, which function best describes the kinetics depends on the oxidation temperature and the thermal condition of the steel. Quenched and tempered samples were shown to oxidise less, resulting in a slower oxidation rate.
Развитие системы Open Banking в России
Authors: Ваганова Оксана Валерьевна , Быканова Наталья Игоревна , Гордя Дарья Викторовна , Голубоцких Владимир Николаевич
Published: April 2022

Цель: статья посвящена определению направлений развития системы открытого банкинга (Оpen Banking) в России и возможностям ее внедрения в деятельность отечественных финансово-кредитных организаций. Обсуждение: в современных условиях активно развивается новое направление цифрового банкинга – открытый банкинг, благодаря которому финансовые организации, в их числе финтех-компании и сервисные компании могут разрабатывать инновационные технологии и услуги. В ходе исследования выявлены факторы, способствующие развитию открытого банкинга в России и определены основные сферы применения и инструменты открытого банкинга. Результаты: изучение этих направлений в сочетании с наблюдениями, касающимися реализации проектов банками-участниками системы Open API на рынке цифрового банкинга относительно России, позволили авторам сформулировать возможные пути развития Open Banking в России и его будущей конкурентоспособности на мировом финансовом рынке.
Хроматографический анализ состава белков плодов расторопши пятнистой, произрастающей в Республике Дагестан
Authors: Рамазанов Арсен Шамсудинович , Балаева Шамсият Абдулмеджидовна , Рудаков Олег Борисович , Селеменев Владимир Федорович
Published: April 2022

Работа посвящена изучению аминокислотного состава белков плодов расторопши пятнистой, произрастающей в нескольких районах Республики Дагестан, отличающихся друг от друга природно-климатическими условиями: Сулейман Стальский, Кайтагский, Магарамкентский, Левашинский и Кулинский районы Дагестана. Эти местности расположены на разной высоте над уровнем моря, для них характерны разные состав почв, количество солнечных дней, объемы осадков, влажность воздуха, средние дневные температуры и др. Эти фенотипические факторы не могли не отразиться на аминокислотном составе дикорастущей расторопши пятнистой. Для определения состава аминокислот использовали стандартизованный метод ионообменной хроматографии с постколоночной дериватизацией нингидрином и спектрофотометрическим детектированием фиолетовых аддуктов аминокислот при 570 нм и желтого аддукта пролина при 440 нм. Установлена вариативность содержания аминокислот в белках расторопши пятнистой в зависимости от условий произрастания. Статистический анализ массива данных по аминокислотному составу белков расторопши пятнистой показал наличие не только значимых симбатных и асимбатных корреляций типа Y=aX+b (коэффициент парной корреляции |R|≥0.55), но и тесных природных корреляций (|R|≥0.80) между содержанием некоторых заменимых и незаменимых аминокислот, между их содержанием в белке и отдельными фенотипическими факторами. Выявленные показатели пищевой ценности белка расторопши пятнистой, выросшей в разных районах Дагестана и установленные фенотипические тренды в составе аминокислот белков расторопши пятнистой могут быть использованы в дальнейших биологических, биохимических и диетологических исследованиях.
Тест-система с адсорбционным чипом для экспресс-диагностики заболеваний репродуктивного тракта
Authors: Хороших Наталья Владимировна , Золотухин Владимир Олегович , Миттова Валентина Олеговна , Мадыкин Юрий Юрьевич , Золотухин Олег Владимирович
Published: April 2022

В последнее время для проведения экспресс-диагностики перед назначением эмпирической фармакотерапии все большую популярность приобретают методы, основанные на pH-метрии. В работе рассмотрена возможность создания тест-системы с адсорбционным чипом на основе хлопковой целлюлозы, модифицированной индикатором для экспресс-диагностики заболеваний мочеполовой системы. В основе метода лежит биологический феномен изменения кислотности при развитии патологического процесса.

Был осуществлен выбор индикатора, способного реагировать на изменение кислотности в диапазоне рН 5.5-7.5, подобран оптимальный растворитель для приготовления раствора индикатора с гипоаллергенными свойствами, высокой способностью к адгезии и умеренной вязкостью, определено необходимое количество раствора для эффективной диагностики и подобран носитель для индикатора. В качестве индикатора был выбран бромтимоловый синий (3’,3’-дибромтимолсульфофталеин).

Предложены условия фиксации бромтимолового синего на целлюлозе, установлены условия предподготовки взятых проб и стандартизации ввода их в чип, исследована длительность сохранения свойств полученного чипа во времени. В результате, была предложена схема закрепления бромтимолового синего на прокладках Kotex. Предлагаемая тест-система, в которой сенсором служит адсорбированный чип на основе целлюлозы, модифицированный индикатором, является оригинальной. Данную сенсорику можно считать одной из разновидностей распределительной хроматографии.

Эффективность разработанной тест-системы была оценена клинически у 50 женщин в возрасте от 19 до 75 лет. В качестве контроля проводили измерение рН влагалищной жидкости стандартным способом и бактериоскопическое исследование мазка, окрашенного по Граму. Установлено, что обработка полученного отклика на изменение окраски адсорбированного на носителе индикатора позволяет установить степень выраженности воспалительного процесса репродуктивного тракта обследуемых женщин. Интенсивность окрашивания тест-системы коррелировала с активностью воспалительного процесса, а не с особенностями микроорганизмов, вызывающих патологический процесс.

Анализ полученных данных дает достоверные результаты для проведения ранней диагностики заболеваний мочеполовой системы инфекционного генеза, приводятся рекомендации по особенностям использования тест-системы.
Изучение термических свойств органо-неорганических композитов с четвертичными аминогруппами на основе магадиита
Authors: Новикова Татьяна Николаевна , Roessner Frank , Селеменев Владимир Федорович
Published: April 2022

Магадиит – слоистый силикат, слои которого состоят из тетраэдров SiO4 и гидратированных подвижных катионов, находящихся между этими слоями; в большинстве случаев такими катионами являются катионы натрия. В его структуре присутствует 3 слоя силиконовых тетраэдров. Наличие у магадиита в межслоевом пространстве подвижных катионов натрия делают его способным к химической модификации. Синтез органо-неорганических композитов можно осуществлять через привитие аминосиланов к межслоевым гидрооксильным группам магадиита. Неорганическая основа в виде слоистого магадиита позволит использовать эти композиты в более широком диапазоне температур в отличии от их органических аналогов. Целью работы было изучение термических свойств органо-неорганических композитов с четвертичными аминогруппами на основе магадиита.

Объектами исследования являлись органо-неорганические композиты с четвертичными аминогруппами на основе магадиита НММСl (магадиит, модифицированный хлоридом N-триметоксисилилпропил–N,N,N-триметиламмония) и НММI (магадиит, модифицированный иодидом N-диметилметоксисилилпропил–N,N,N-триэтиламмония).

Термические свойства синтезированных композитов были исследованы с помощью термогравиметрического метода анализа и метода ИК-спектроскопии диффузного отражения в режиме «in situ» в процессе непрерывного нагревания образцов до достижения определенных температур. Выбор температур ИК-исследования обуславливался положением максимумов на термограммах гибридных материалов.

В работе были получены и проанализированы термогравиметрические кривые и ИK-спектры диффузного отражения магадиита модифицированного аминосиланами с четвертичными аминогруппами. Определены предполагаемые этапы многостадийного процесса разложения органо-неорганических композитов и их температурные диапазоны.

Предложено, что процесс разложения органо-неорганических композитов с четвертичными аминогруппами на основе магадиита состоит из дегидратации, деструкции привитого органического слоя с восстановлением свободных силанольных групп, распада связанных водородной связью силанольных групп с дальнейшим их дегидроксилированием. Максимальная температура, до которой исследуемые гибридные материалы сохраняют свои свойства, составила T≤130°C, что практически почти в два раза выше температуры органических аналогов – анионообменников.
[RETRACTED] NovoFit Keto Reviews - Does It Really Works? v1
Authors: not provided novofitketoreviewsrks
Published: April 2022

[RETRACTED]

NovoFit Keto Reviews - Does It Really Works?
[RETRACTED] Greenhouse Pure CBD Gummies | Help To Lower Stress Hormone Levels And Blood Pressure (Greenhouse CBD Gummies) v1
Authors: Pure CBD Gummies GreenHouse
Published: April 2022

[RETRACTED]

GreenHouse Pure CBD Gummies
[RETRACTED] Pioneer Woman CBD Gummies - 100% Natural Herbal And Reduce Your all Pain! v1
Authors: Woman CBD Gummies Pioneer
Published: April 2022

[RETRACTED]

Pioneer Woman CBD Gummies
[RETRACTED] Aktiv Apex Rogue Male Enhancement Reviews: Negative Side Effects or Real Male Enhancement? (2022 Update) v1
Authors: not provided officialapexrogue
Published: April 2022

[RETRACTED]

Aktiv Apex Rogue Male Enhancement Aktiv Apex Rogue Male Enhancement – Official Website Link – Click Here
Hammadde tedarik sorunlarının Türkiye mobilya üretimi açısından değerlendirilmesi ve bir projeksiyon çalışması
Authors: TİRYAKİ Sebahattin , AYDIN Aytaç , ADANUR Hakan
Published: April 2022

Mobilya, genel bir ifade ile insanların günlük yaşamdaki ihtiyaçlarını dikkate alarak yaşadıkları ortamları donattıkları veya dekore ettikleri taşınabilir eşyalardır. Mobilya sanayisi yarattığı katma değer ile ülkemiz ekonomisi açısından önemli sektörlerinden birisi olmuştur. Ancak, fiyat ve miktar açısından hammadde temininde karşı karşıya kalınan dalgalanmalar sektörü olumsuz olarak etkileyebilmektedir. Bu durum, günümüz pandemi koşullarında daha da ön plana çıkmış olup sektör üzerinde etkisini hissettirmiştir. Bu çalışma kapsamında, mobilya üretiminde hammadde ile ilgili olarak karşı karşıya kalınan tedarik sorunları değerlendirilmiş ve mobilya üretim sürecinin ana girdilerinden birisi olan MDF/HDF’nin 2001-2020 yıllarına ait üretim, ithalat ve ihracat verileri FAO (Birleşmiş Milletler Gıda ve Tarım Teşkilatı) resmi web sitesinden alınmış ve analiz edilmiştir. Analizlerde basit doğrusal regresyon yöntemi ile modeller oluşturulmuş ve anlamlı regresyon modelleri kullanılarak tahminler ve projeksiyonlar yapılmıştır. Çalışma sonucunda, ithalat verileri kullanılarak oluşturulan modelin istatistiksel olarak anlamsız olduğu görülmüş, öte yandan üretim ve ihracat verileri için kurulan anlamlı modeller kullanılarak tahminler gerçekleştirilmiştir. 2030 yılı dikkate alınarak yapılan projeksiyonlar sonucunda MDF/HDF’nin üretim ve ihracat değerlerinde kayda değer bir artış olacağı öngörülmektedir.
Key markers for diagnosis of minimal residual disease in multiple myeloma
Authors: Tolstykh E. E. , Tupitsyn N. N.
Published: April 2022

Introduction. Therapeutic advances in recent years, the appearance on the market each time of new drugs that allow patients to achieve complete remission, a long period without progression dictate the need to control treatment by monitoring residual disease in multiple myeloma. Monitoring of multiple myeloma is the detection of a small number of tumor cells after therapy in a patient, which may be the cause of recurrence of the disease – control of minimal residual disease (MRD). This article discusses the key diagnostic markers (CD45, CD56 and CD19) of minimal residual multiple myeloma disease at initial diagnosis and after induction therapy. There are various diagnostic methods of research that can reliably assess the response to therapy and predict the occurrence of relapse. The main methods for detecting MRD are allele-specific polymerase chain reaction, next-generation sequencing and multicolor flow cytometry. The diagnosis of MRD by flow cytometry is the most widely used quite fast, quantitative, sensitive and affordable method, it is used for the primary diagnosis of multiple myeloma, as well as for monitoring MRD. It is important to identify the aberrant immunophenotype during the initial diagnosis for the correct subsequent assessment of MRD. MRD of multiple myeloma is considered an important component in the course of patient therapy before hematopoietic stem cell autotransplantation to assess the effectiveness of therapy, control and prognosis of the disease.

The aim of the work MRD-study with the key diagnostic markers in multiple myeloma (CD45, CD56 and CD19).

Materials and methods. The study was carried out in 59 patients with multiple myeloma. For all patients, in addition to standard methods of diagnosis and staging of the disease, bone marrow morphology (myelogram) and immunophenotype were examined. Eight-color flow cytometry with a panel of monoclonal antibodies for the diagnosis of plasma cell tumors Euro-Flow 2012 was used to diagnose MRD.

Results. MRD was assessed by markers CD45, CD56 and CD19 in patients with multiple myeloma after induction therapy. The incidence of MRD-positivity for CD45 was 87.5 %, for CD56 – 97.5 %, for CD19 – 95.5 %. The incidence of MRD-negative status was for CD45 was 12.5 %, for CD56 – 2.5 % and for CD19 – 4,5 %.

Conclusion. The use of a complex of these markers allows the most accurate determination of the MRD-negative status, taking into account the primary immunophenotype of malignant plasma cells.
The analysis of the consumption level of antihypertensive drugs and statins in a retail pharmacy of the Samara Region in 2015–2020
Authors: Petrukhina I. K. , Lebedev P. A. , Gladunova E. P. , Ryazanova T. K. , Garanin A. A. , Blinkova P. R.
Published: April 2022

Objective: to determine the compliance of antihypertensive drugs consumption with the trends of modern pharmacotherapy.

Material and methods. The analysis of the consumption level of antihypertensive drugs, their fixed combinations (FC), as well as statins in the retail sector of the pharmaceutical market of the Samara Region in 2015–2020 was carried out. The material of this retrospective study was information about the nomenclature and volume of drug sales in physical and monetary terms for the period under review in one of the retail pharmacies of the Samara Region. The traditional method of pharmacoepidemiological analysis aimed at studying the correctness, completeness and preferences of drug use in real practice is questionnaires for physicians and patients. The main antihypertensive drugs (diuretics, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, β-blockers) and their FC were selected for the analysis.

Results. Long-term use of medications aimed at reducing high blood pressure and hypercholesterolemia is seen as an effective strategy for reducing cardiovascular complications and mortality in both primary and secondary prevention. The analysis of sales of basic cardiological drugs in the pharmacy network segment of the Samara Region in 5-year dynamics showed that the consumption of hypotensive drugs and statins makes up 4.72% of the total item sales, with prevalence of angiotensin-converting enzyme inhibitors (28.0%) and β-blockers (23.5%), with insufficient consumption of FC (23.7%), extremely low sales of statins (7.58%).

Conclusion. The structure of the studied segment of the pharmaceutical market is conservative with insufficient positive dynamics in the consumption of effective modern drugs and their FC.
Efficacy of targeted drugs for the treatment of adults with moderate-to-severe plaque psoriasis in the Russian Federation: a systematic literature review update
Authors: Sokolova V. D. , Sableva N. A. , Mladov V. V. , Tolkacheva D. G.
Published: April 2022

Background. A systematic literature review helps to identify the main treatment options, and evidence synthesis supports decision-making by comparing clinical efficacy of different treatments. Nowadays new drugs and clinical trials emerge rapidly, so previous network meta-analyses might need to be updated.

Objective: to update the existing systematic review and network meta-analysis comparing efficacy of targeted drugs in adult patients with moderate-to-severe plaque psoriasis by adding randomized clinical trials (RCTs) on a new interleukin (IL) 23 inhibitor registered in the Russian Federation – risankizumab, and other RCTs published after 2019; to reassess the Psoriasis Area and Severity Index (PASI) 75/90 numbers of patients needed to treat to achieve clinical response to therapy and the costs per responder for 12–16 weeks and 1 year of therapy.

Material and methods. We updated our systematic literature search in the PubMed/MEDLINE and Embase databases. Evidence synthesis included RCTs evaluating the efficacy of adalimumab (ADA), infliximab (INF), etanercept (ETN), certolizumab pegol (CZP), ixekizumab (IXE), netakimab (NTK), secukinumab (SEC), risankizumab (RIS), guselkumab (GUS), ustekinumab (UST), tofacitinib (TOFA), and apremilast (APR) after 12 weeks of therapy. The Bayesian meta-analyses with meta-regression models were performed in order to account for high heterogeneity in patient characteristics and significant differences in the placebo response rates. The considered drugs were ranked based on values of surface under the cumulative ranking curve (SUCRA). Additionally, drug class analyses were carried out.

Results. Twenty three new RCTs were added to the network. IL-23 inhibitor RIS, recently approved in the Russian Federation, has joined the group of the most efficacious drugs, such as IL-17 inhibitors NTK and IXE, as well as IL-23 inhibitor GUS. In terms of PASI 75, RIS and IXE showed superiority compared to all tumor necrosis factor alpha (TNFα) inhibitors (INF, ADA, ETN), small molecules (TOFA and APR), and IL-12/23 inhibitor UST, while NTK and GUS were characterized by comparable efficacy with INF and outperformed the remaining drugs. There were no statistically significant differences in efficacy between all the TNFα inhibitors. GUS, IXE, INF, NTK, RIS and SEC demonstrated that no more than 2 patients need to be treated to achieve one PASI 75 response, and no more than 3 need to be treated for one PASI 90 response (according to the upper limit of 95% credible interval). Same as in the previously published study, NTK showed the lowest costs per responder for both 12-week and 1-year periods.

Conclusion. The addition of head-to-head trials and increased statistical power of the network revealed previously unidentified significant differences between treatment options for moderate-to-severe plaque psoriasis.
Generalized actinomycosis of the pelvic organs. Clinical case
Authors: Kazakova A. V. , Lineva O. I. , Trupakova A. A. , Kiyashko I. S. , Kuznetsova L. V. , Petyanova V. A.
Published: April 2022

Here, a clinical case of generalized actinomycosis of the pelvic organs occuring very rarely usually observed in immunocompromised patients is presented. Patient T. referred to the women's clinic with complaints of prolonged genital discharge, itching, burning, and occasional sub-fever. The patient had a history of prolonged hormonal immunosuppressive therapy. After a thorough examination, the patient was consulted by two oncologists. Preliminary diagnosis: suspicio cancer coli; suspicio cancer vaginae. In order to clarify the diagnosis, an in-hospital multifocal scalpel biopsy was performed. The biological material obtained was sent out for intravital pathological and anatomical examination; no signs of malignancy were found. To prevent complications during surgery, the patient underwent separate diagnostic scraping of the uterine cavity and cervical canal after repeated sanitation of the vagina and additional patient examination; hysteroscopy; vulval biopsy; colpocentesis. The final diagnosis was made after obtaining the results of in-surgery microbial culture on nutrient media. Active growth of actinomycetes was detected in the material obtained. The final clinical diagnosis was pelvic actinomycosis, generalized form. Patient T was discharged in satisfactory condition after antibacterial treatment according to the diagnosis for further under gynecologist observation at the women's clinic.
Group Art Therapy Resource in Teen Bullying Prevention in Adolescence Environment
Authors: Lebedeva A.L.
Published: April 2022

The process of bullying poses a serious threat to adolescents’ psychosocial and academic adjustment to the educational environment. The negative consequences of bullying include increased likelihood of reduced attendance, academic success, and commission of offences by students. The work tasks of the educational psychologist include the formation of a psychologically safe atmosphere in educational organizations, improve of emotional intelligence and communicative abilities of students. Activities aimed at the prevention of bullying are included in the general program of socio-psychological adaptation of first-year students of the College of Tourism of St. Petersburg. The article presents the experience of appropriate training for students.
Successful application of conditioned culture medium for the treatment of a chronic wound of an amputation stump: a clinical case
Authors: Cherepanin Andrey I. , Pavlova Olga V. , Kalsin Vladimir A. , Konoplyannikov Mikhail A. , Kucherova Olga N. , Baldin Victor L. , Deryabin Sergey V.
Published: April 2022

Background: Amputation of the lower extremities is a necessary procedure to save a patient with critical arterial and neurotrophic disorders in the lower extremities. The amputation stump-related complications develop in many patients with diabetes mellitus (up to 40% of the total population).
Clinical case description: Patient Yu., 64 years old, was admitted on October 19, 21 for an outpatient treatment of purulent-necrotic wounds of the amputation stump of the right lower limb. А high amputation was performed on September 24, 2021 due to thrombosis of the femoral-tibial bypass, installed on September 08, 2021 (bypassing below the knee joint gap with a Vascutek 7 mm synthetic prosthesis on the right) and the development of critical ischemia of the right lower limb with necrosis of the distal phalanges of the right foot toes. The wound was assessed according to the Bates-Jensen scale (BJ) and examined according to the developed protocol. The wound treatment was carried out according to an individual plan using a conditioned culture medium from mesenchymal stem cells (CM-MSCs), which stimulates angiogenesis and improves remodeling and recovery in the wound area. CM-MSC application made it possible to reduce the healing time and achieve a scarless closure of the tissue defect.
Conclusion: The use of CM-MSC can be an effective method for healing a purulent-necrotic postoperative wound resulting from amputation of a limb in patients with critical ischemia of the lower extremities.