bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Crystal Structure of Novel Planar Chiral Diferrocenylimine-Diols X-Ray Crystal Structure of [(η5-C5H5) Fe{ (η5-C5H3) CPh2OHCH (CH3) N=CHC6H4CH=NCH (CH3) CPh2OH (η5-C5H3) }Fe (η5-C5H5)]
Authors: Zhang Yu-Mei , Zhou Zhi-Ming , Jiang Fei
Published: December 2009

Four novel planar chiral diferrocenylimine-diols 6 (6a, 6b, 6c, 6d) have been designed and prepared, and the structure of 6a determined by X-ray crystallography. Compound 6a [(η5-C5H5) Fe{ (η5-C5H3) CPh2OHCH (CH3) N=CHC6H4CH=NCH (CH3) CPh2OH (η5-C5H3) }Fe (η5-C5H5)] is enantiomerically pure and crystallises in the noncentrosymmetric P212121 space group, exhibiting a “∩” shape, phenyl ring as a bridge linking two ferrocenes on both sides via C=N, and the pair of ferrocenyl groups adopting the E-configuration.
Synthesis and Dynamic 13C NMR Study of New System Containing Polarised Carbon–Carbon Double Bonds from Reaction between Cyclohexyl Isocyanide and Ethyl Propiolate in the Presence of N, N′-Dimethylbarbituric Acid
Authors: Maghsoodlou Malek T. , Khorassani Seyyed M.H. , Hazeri Nourollah , Marandi Ghasem , Bijanzadeh Hamid R.
Published: December 2009

The adduct produced in the reaction between cyclohexyl isocyanide and ethyl acetylenecarboxylate was trapped by N, N′-dimethylbarbituric acid. Dynamic NMR effects were observed in the NMR spectra of these compounds and were attributed to restricted rotation around the alkyl-nitrogen single bonds and the polarised carbon–carbon double bond.
An Improved Procedure for the Synthesis of 2-Hydroxybenzaldehyde and 2-Hydroxynaphthalene-1-Carbaldehyde
Authors: Mokle Shyam S. , Dawane Bhaskar S. , Sayyed Mudassar A. , Vibhute Yeshwant B.
Published: December 2009

An easy and convenient method is reported for the synthesis of 2-hydroxybenzaldehyde and 2-hydroxynaphthalene-1-carbaldehyde from corresponding phenols by Reimer–Tiemann reaction using aqueous ethyl alcohol and avoiding steam/vaccum distillation.
Medium-Size Cyclophanes, 681. Synthesis and Bromination of 1,2-Dimethyl[2.3]Metacyclophan-1-Enes
Authors: Yamato Takehiko , Hironaka Tohru , Shiino Mikiko , Saisyo Tatsunori , Miyamoto Shinpei
Published: December 2009

McMurry cyclisation of 1,3-bis(3-acetyl-5- tert-butyl-2-methoxyphenyl)propane (4) afforded anti- and syn-1,2-dimethyl[2.3]metacyclophan-1-enes 5, which were converted to the corresponding 1,2-bisbromomethyl[2.3]metacyclophan-1-enes (8) by treatment with excess BTMA Br3.
Natural Phosphate and Potassium Fluoride Doped Natural Phosphate as New Catalysts for the Vilsmeir–Haack type Reaction
Authors: Zahouily Mohamed , Bahlaouan Bouchaib , Abrouki Younes , Salah Mohamed , Bahlaouan Ouafa , Rayadh Ahmed , Aadil Mina , Sebti Saïd
Published: December 2009

The catalytic activity of the inexpensive natural- or potassium fluoride doped phosphates as bases was evaluated in a Vilsmeier–Haack type reaction. High efficiency, in term of chemical yields and reaction rates was found in the preparation of 2-chlor-3-cyanopyridines starting from 2-propylidene-malonitriles.
Microwave-Assisted Efficient Synthesis of Diimines in Dry Media Using Silica Gel Supported Sodium Hydrogen Sulfate as Reusable Solid Support
Authors: Bazgir Ayoob
Published: December 2009

A simple and efficient method for synthesis of diimines using silica gel supported sodium hydrogen sulfate as reusable solid support in solvent-free conditions under microwave irradiation is described.
A One-Pot Reaction of Meldrum's Acid with Ethyl Orthoformate and Hydrazines
Authors: Li Jing-Hua , He Jin-Huan
Published: December 2009

Meldrum's acid has been converted into its corresponding nitrogenous derivatives under a parallel condition by successive treatment with triethyl orthoformate and hydrazines in one-pot reaction.
[Ce(No3)3]3.H2IO6: Efficient Oxidation Reactions Under Solvent-Free Conditions
Authors: Shirini F. , Esm-Hosseini M. , Hejazi Z. , Mohammadpoor-Baltork I.
Published: December 2009

Efficient solvent-free oxidation of alcohols, deprotection and oxidative deprotection of trimethylsilyl ethers and oxidative deprotection of oximes using tris [trinitratocerium (IV)] paraperiodate (TTCPP) is reported.
2-(3-Arylhydrazono-3-Formyl-2-Oxopropyl)-1H-Isoindole-1,3(2H)-Dione in Heterocyclic Synthesis. Novel Derivatives of Pyridazin-6(1H)-One, Pyridazin-6(1H)-Imine, and Pyrazolo[5,1-c][1,2,4]Triazine Incorporating an N-(2-Oxoethyl)Phthalimide Moiety
Authors: Al-Omran Fatima , El-Khair Adel A.
Published: December 2009

A novel series of 2-(3-arylhydrazono-3-formyl-2-oxopropyl)-1 H-isoindole-1,3-(2 H)-diones has been prepared and their utility as building blocks in the synthesis of novel derivatives of pyridazin-6(1 H)-ones, pyridazin-6(1 H)-imines, and pyrazolo[5,1-c][1,2,4]triazines incorporating a N-(2-oxoethyl)phthalimide moiety is investigated.
Synthesis of Polyfunctional Ketenimines and 1-Azadienes use of Tert-Butyl Isocyanide and Acetylenic Esters in the Presence of 3-Chloropentane-2, 4-Dione
Authors: Asghari Sakineh , Qandalee Mohammad , Bijan-Zadeh Hamid Reza
Published: December 2009

The 1:1 reactive intermediate generated by the addition of tert-butyl isocyanide to dialkyl acetylenedicarboxylates was trapped by 3-chloropentane-2, 4-dione to yield polyfunctionalised ketenimines and 1-azadienes.
Preparation of a Novel C3 Symmetrical Hexahomotrithiacalix[3]arene that Binds Ag+ with High Selectivity
Authors: Kohno Kazufumi , Takeshita Michinori , Yamato Takehiko
Published: December 2009

It has been demonstrated that a novel C3 symmetrical receptor, hexahomotrithiacalix[3]arene 1a, which contains sulfur bridges, is able to form a complex with Ag+.
The New Γ-Spiroiminolactone Synthesis by Reaction between Alkyl or Aryl Isocyanides and 1,10-Phenanthroline-5,6-Dione in the Presence of Acetylenic Esters
Authors: Maghsoodlou Malek Taher , Khorassani Sayyed Mostafa Habibi , Hazeri Nourollah , Heydari Reza , Marandi Ghasem , Nassiri Mahmoud
Published: December 2009

The 1:1 intermediate generated by the addition of alkyl and aryl isocyanides to dialkyl acetylenedicarboxylate is trapped by 1,2-dicarbonyl compounds such as 1,10-phenanthroline-5,6-dione (phendione) to yield iminolactones in good yields.
Spectroscopy and Electrochemistry of Cobalt(Iii) Salophen Complexes
Authors: Sarvestani Ali Hossein , Mohebbi Sajjad
Published: December 2009

Novel Co(III) complexes with general formula, [Co(chel)(PBu3)]ClO4.H2O, where chel = 5-Brsalophen, 5-NO2salophen, 5-MeOsalophen and 4-MeOsalophen, were synthesised and characterised. The spectroscopic and electrochemical properties of these complexes and [Co(salophen)(PR3)]ClO4.H2O (R = PBu3 and PPh3) complexes were investigated.
Novel Synthesis and Stereochemical Structure of 2H-2,6-Methano-1,3-Benzoxazocine-5-Carbohydrazides
Authors: Girgis Adel S. , Hosni Hanaa M.
Published: December 2009

A novel synthetic approach for 5,6-dihydro-2,4-disubstituted-2 H-2,6-methano-1,3-benzoxazocine-5-carbohydrazides 4a–j was achieved through the reaction of 1-aryl-3-(2-hydroxyphenyl)prop-2-en-1-ones 1a–c with cyanoacetohydrazones 2a,b in the presence of sufficient amount of secondary amines 3a,b. Single crystal X-ray diffraction study of 4c supports the established structure and reveals that the relative configuration is 2 R,5 S,6 R.
Synthesis and Dynamic 1H NMR Study of Stable Phosphorus Ylides Derived from Reaction between Heterocyclic NH-Acids and Triphenylphosphine in the Presence of Acetylenic Esters
Authors: Hazeri Nourollah , Khorassani Sayyed M. H. , Maghsoodlou Malek T. , Marandi Ghasem , Nassiri Mahmoud , Shahzadeh Aqil G.
Published: December 2009

Stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylate in the presence of a strong NH-acid, such as 2-indolinone, 3-acetylindole and saccharine. These stable ylides exist in solution as a mixture of two geometrical isomers as a result of restricted rotation around the carbon–carbon partial double bond resulting from conjugation of the ylide moiety with the adjacent carbonyl group. Dynamic effects are observed in 1H NMR spectra. The calculated free-energy of activation for interconversion of the rotational isomers in 2-indolinone amounts to about 68.2±2 J/mol.
Theoretical study of the insertion reaction of singlet phosphinidene with hydrogen sulfide
Authors: Yin Ping , Wang Chunhua , Zheng Hegen , Yin Gui , Zhou Taoyu
Published: December 2009

The mechanism of the insertion reaction of singlet phosphinidene with hydrogen sulfide has been studied at HF/6-31G(d), MP2(full)/6-31G(d) and CCSD(T)/6-311 + G(d, p) levels, taking place through a three-membered ring transition state. The thermodynamic and kinetic properties of this reaction channel in the temperature range of 100–1500K have been studied, and it is concluded that the reaction is thermodynamically favoured at low temperature and kinetically favoured at high temperature.
Advances in the direct iodination of aromatic compounds
Authors: Hanson James R.
Published: December 2009

Methods for the direct iodination of aromatic compounds are reviewed.
Regioselective synthesis of 7-acetyl-11c-methyl-4b,5,7,11c-tetrahydro[1]benzofuro[2′,3′:4,5]thiopyrano[2,3-b]indoles by sequential Claisen rearrangement of 2-(4′-aryloxybut-2′-ynylthio)-1-acetylindoles
Authors: Majumdar K.C. , Alam S.
Published: December 2009

Hitherto unreported indole-annulated pentacyclic heterocycles containing oxygen, nitrogen and sulfur have been synthesised by thermal Claisen rearrangement followed by Lewis acid catalysed Claisen rearrangement. 9-Acetyl-4-aryloxymethyl-2,9-dihydrothiopyrano[2,3- b]indoles are regioselectively synthesised in 80–85 % yield by thermal rearrangement of 2-(4′-aryloxybut-2′-ynylthio)-1-acetylindoles. A second, Lewis acid catalysed, rearrangement gave 7-acetyl-11c-methyl-4b,5,7,11c-tetrahydro[1]benzofuro[2′,3′: 4,5]thiopyrano[2,3- b]indoles in yields of 85–90 %. The thermal Claisen rearrangement in refluxing N,N-diethylaniline for 3 h gave the same products in lower yield (50–54 %).
Synthesis and crystal structure studies of (2RS)-3-[(2RS)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]-2-(pyridin-3-yl)thiazolidin-4-one
Authors: Kavitha Chandagirikoppal V. , Basappa  , Mantelingu Kempegowda , Doreswamy Sundararaj I. , Prasad Javaregowda Shashidhara , Rangappa Kanchugarakoppal S.
Published: December 2009

The compound (2 RS)-3-[(2 RS)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]-2-(pyridin-3-yl)-thiazolidin-4-one 4 was synthesised via one-pot three-component system in three different methods, such as conventional (DCC), MW irradiation with solvent and MW irradiation without solvent methods. Among them, MW irradiation without solvent has the advantage of short time with high yield and environmentally benign. The synthesised compound was characterised by spectroscopic technique and finally confirmed by X-ray diffraction. The compound crystallises in the triclinic crystal system with Z = 2 in the space group P1. The cell parametres are a = 10.317(9) Å, b = 10.280(1) Å, c = 11.408(6) Å, α = 73.824(6)° β = 70.122(5)° γ = 70.293(3)° and R1 = 0.0527 for 10124 reflections [ I>2σ( I)]. The cyclohexane ring of the molecule is in chair conformation. The molecule exhibits intermolecular hydrogen bonds of type N–H…O and C–H…O.
Synthesis, spectroscopy and crystal structure of 2-ethyl-6-(4-nitrophenyl) imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde
Authors: Begum Noor Shahina , Vasundhara D.E. , Girija C.R. , Kolavi G.D. , Hegde V.S. , Khazi I.M.
Published: December 2009

The preparation of 2-ethyl-6-(4-nitrophenyl)imidazo[2,1- b][1,3,4]thiadiazole-5-carbaldehyde (4) is described and its crystal structure is determined and discussed.
Stereoselective synthesis of the optical isomers of a new muscarinic receptor antagonist, quinuclidin-3-yl 2-(cyclopent-1-enyl)-2-hydroxy-2-phenylacetate
Authors: Liu Yu-Min , Liu He , Zhong Bo-Hua , Liu Ke-Liang
Published: December 2009

The enantiopure isomers of a new muscarinic receptor antagonist, quinuclidin-3-yl 2- (cyclopent-1-enyl)-2-hydroxy-2-phenylacetate were synthesised by a practical stereoselective synthetic method, using pivaldehyde as steric hindrance agent from the chiral starting material, ( S) or ( R)-mandelic acid. The isomers were obtained with 72–78 % yields in 98–99 % e.e.
Medium-size cyclophanes, 691 Synthesis and ipso-nitration of di-tert-butyl-1,2-dimethyl[2.10]metacyclophan-1-enes
Authors: Yamato Takehiko , Hironaka Tohru , Miyamoto Shinpei
Published: December 2009

Syn-5,21-di- tert-butyl-1,2-dimethyl[2.10]metacyclophan-1-ene syn-4 was prepared by the McMurry reaction of 1,10-bis(3-acetyl-5- tert-butyl-2-methoxyphenyl)decane 3, and nitrated with fuming nitric acid to give the two-fold ipso-nitration product syn-5 in good yield.
The synthesis of 2-hydroxymethyl derivatives of phenols
Authors: Payne Peter , Tyman John H.P. , Mehet Satinder K. , Ninagawa Akira
Published: December 2009

2-Hydroxymethylphenols have been prepared in good yield by reduction with sodium borohydride of the precursor aldehydes, obtained regiospecifically from reaction of phenols with paraformaldehyde in toluene containing stannic chloride and tri- n-butylamine. By contrast, reaction of phenols with either paraformaldehyde under anhydrous conditions or with aqueous formaldehyde results in formation of both the hydroxymethyl and the bishydroxymethyl derivatives. Cyclic acetals of the precursor aldehydes are readily accessible.
Grindstone chemistry: (diacetoxyiodo)benzene-mediated oxidative nuclear halogenation of arenes using NaCl, NaBr or I2
Authors: Karade N.N. , Tiwari G.B. , Huple D.B. , Siddiqui T.A.J.
Published: December 2009

A technique of “Grindstone chemistry” is applied to the solvent-free halogenation of arenes with NaCl, NaBr or I2 using (diacetoxyiodo)benzene as the oxidant. Improved yields and higher purities of the products are observed compared with those from established methods.
A simple and effective glycine-catalysed procedure for the preparation of oximes
Authors: Maheswara Muchchintala , Siddaiah Vidavalur , Gopalaiah Kovuru , Rao Vallabhaneni Madhava , Rao Chunduri Venkata
Published: December 2009

Ketoximes and aldoximes are expeditiously prepared by the reaction of the corresponding carbonyl compound with hydroxylamine hydrochloride in dimethylformamide, in the presence of a sub-stoichiometric quantity of glycine at room temperature. Mild (non-hydroxylic) conditions, simple workup and high yield characterise the methodology.
Stereoselective synthesis of pyrrole phosphonate esters from the reaction of triphenylphosphite and dimethyl acetylenedicarboxylate in the presence of pyrrole in aqueous solution
Authors: Maghsoodlou Malek Taher , Khorassani Sayyed Mostafa Habibi , Heydari Reza , Charati Faramarz Rostami
Published: December 2009

The reaction of triphenylphosphite and dimethyl acetylenedicarboxylates (DMAD) in the presence of pyrrole derivatives in an aqueous media led to pyrrole phosphonate esters derivatives.
CuI/L-proline potassium salt catalysed synthesis of vinyl sulfones via coupling reaction of vinyl bromides with sulfinic acid salts in ionic liquid
Authors: Bao Weiliang , Wang Congna
Published: December 2009

Catalysed by CuI/L-proline potassium salt, which serves as both base and ligand, the coupling reaction of vinyl bromides with sulfinic acid salts occurs at 110 °C in ionic liquid to give the corresponding vinyl sulfones in good yields.
The Synthesis of Novel Ethyl 4-(Substituted Amino)Isothiazolo[5,4-b]-Pyridine-5-Carboxylates
Authors: Mukherjee Attreyee , Sarkar Mili , Mahalanabis Kumar K.
Published: December 2009

The preparation of ethyl 4-(substituted amino)isothiazolo[5,4- b]pyridine-5-carboxylates via nucleophilic displacement of 4-chloroisothiazolo[5,4- b]pyridines by amino compounds is reported.
Synthesis and Antimicrobial Activity of Some Annelated Quinazoline Derivatives
Authors: Aly Aly Abdel-Maboud
Published: December 2009

A highly efficient and versatile synthetic approach to the synthesis of annelated quinazoline derivatives viz [1,2,4]triazino[4,3- c]quinazoline 5–7, [1,3,5]triazino[1,2- c]quinazoline 11, thiazolidinylquinazoline 9, quinazolino[4,3- b] quinazolin-8-one 12 and imidazoquinazolines 14a,b,15. Also, a variety of pyrazolylquinazolines 19–21, pyrimidinylquinazolines 22a,b were obtained via a sequence of heterocyclisation reactions of 4-methyl- N-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]benzenesulfonamide (2) with different reagents. The new compounds were synthesised with the objective of studying their antimicrobial activity.
Kinetics of the Nucleophilic Substitution Reactions of Methyl 2,4-Dichloro-3,5-Dinitrobenzoate with Piperidine, Piperazine, Morpholine and Thiomorpholine in Methanol and Benzene
Authors: Fathalla Magda F. , Hamed Ezzat A.
Published: December 2009

The kinetic of the nucleophilic substitution of methyl 2,4-dichloro-3,5-dinitrobenzoate with piperidine, piperazine, morpholine and thiomorpholine in methanol and benzene were determined spectrophotometrically at different amine concentrations and at temperatures ranging from 25 to 45 °C. The second order rate constants and the thermodynamic parameters show that the reactions are not amine catalysed and are greatly dependent of the nature of solvent and amine. UV, IR, 1H NMR, and elemental analysis are used to prove the aminodechlorination at C–2.
Synthesis of a Series of 2,3-Disubstituted 4H-1,4-Benzothiazines and X-ray Crystal Structure of Ethyl 7-Chloro-3-Methyl-4H-1,4-Benzothiazine-2-Carboxylate
Authors: Dandia Anshu , Sarawgi Pritima , Hursthouse Michael B. , Bingham Ann L. , Light Mark E. , Drake John E. , Ratnani Raju
Published: December 2009

The reaction between 2-aminobenzenethiol and ethyl acetoacetate is studied under a variety of conditions, and a procedure for the exclusive synthesis of 1,4-benzothiazines by the neat reaction of substituted aminothiols with β-ketoesters and β-dicarbonyl compounds in 85–96% yield is described. With microwave heating, even when both the reactants are solid, yields are high, reaction times brief, and work-up easy. A facile reaction is also observed even in a solid-state reaction. The molecular structure of ethyl 7-chloro-3-methyl-4 H-1,4-benzothiazine-2-carboxylate (4d) was determined by single-crystal X-ray diffraction.
Tin-mediated Reduction of Azoarenes to Hydrazoarenes Using Hydrazine Hydrate
Authors: Dinesh B. , Abiraj K. , Srinivasa G.R. , Gowda D. Channe
Published: December 2009

The controlled reduction of azoarenes to the corresponding hydrazoarenes using tin and hydrazine hydrate is reported. The reduction proceeds smoothly at room temperature furnishing the hydrazoarene in excellent yield without the formation of an aniline.
Functionalisation of Indene
Authors: Tutar Ahmet , Çakmak Osman , Balci Metin
Published: December 2009

Dibromo- and tribromoindane were synthesised by bromination of indene. Treatment of dibromo- and tribromoindane with various silver salts (silver acetate, perchlorate, sulfate and nitrate) in different solvents opened up an entry to the synthesis of various di- and tri-substituted indane derivatives.
Unexpected Results in the Friedländer Reaction of 4-aryl-7,7-Dimethyl-5-Oxo-5,6,7,8-Tetrahydro-4H-[1]Benzopyran-3-Carbonitriles
Authors: León Rafael , García Antonio G. , Marco-Contelles José
Published: December 2009

In the Friedländer reaction of 4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4 H-[1]benzopyran-3-carbonitriles (1, 2), we have detected and isolated the unexpected imidates 5 and 6, respectively, in addition to the expected tetracyclic tacrine-like derivatives.
Synthesis of 4-Tert-octylphenol and 4-Cumylphenol by Metal Triflate and Metal Triflimidate Catalysts
Authors: Le Rouzo Guillaume , Morel-Grepet Marielle , Simonato Jean-Pierre
Published: December 2009

Metal triflates and metal triflimidates are shown to catalyse efficiently the Friedel–Crafts alkylation of phenol with alkenes. Bismuth, copper and scandium triflates lead to very good yields with excellent para-selectivities.
Synthesis and Inclusion Properties of O-tris(benzyloxy) Hexahomotrioxacalix[3]Arenes
Authors: Yamato Takehiko , Rahman Shofiur , Kitajima Fumika , Xi Zeng , Gil Jeong Tae
Published: December 2009

O-benzylation of hexahomotrioxacalix[3]arene with benzyl bromide gave tri- O-benzylated products with cone and partial-cone conformation, in a ratio governed by the base used. cone-Tris- O-benzyloxy derivative shows a selectivity for the n-butylammoniun ion.
Microwave–assisted Transformation of α,β- and β,γ-Unsaturated Nitroalkenes into Carbonyl Compounds
Authors: Das Deba D. , Nayak Amalendu , Nanda Bhagabat , Das Nalin B.
Published: December 2009

Vinyl and allylic nitroalkenes have been converted into the corresponding carbonyl compounds in good yield using tin(II) chloride dihydrate under microwave irradiation.
Unusual Twisted Intramolecular Charge Transfer Processes of 4,4′-Diaminodiphenylsulfone in β-cyclodextrin: A Study by Electronic Spectra
Authors: Enoch I.V. Muthu Vijayan , Swaminathan Meenakshisundaram
Published: December 2009

Analysis of the absorption and fluorescence characteristics of 4,4′-diaminodiphenylsulfone (4DADPS) in aqueous β-cyclodextrin (β-CDx) solution under different acidic conditions reveals that: (i) the twisted intramolecular charge transfer state (TICT) is more populated than the locally excited (LE) state of 4DADPS in β-CDx; and (ii) the protonation of the monocation of 4DADPS in the S0 and S1 states in β-CDx requires more acidic conditions than in the absence of β-CDx. The higher stabilisation of the TICT state compared to the LE state of 4DADPS in β-CDx inclusion complex is contrary to normal observation. This anomalous behaviour is explained by the geometry of the 1: 1 inclusion complex.
A Facile One-Pot Synthetic Method for 1,2,4-Triazoles and 1,3-Disubstitued Thioureas
Authors: Singh Okram Mukherjee , Singh Sarangthem Joychandra
Published: December 2009

The reaction of arylisothiocyanates with triethylamine and acylhydrazides in the presence of mercuric acetate has been studied. The reaction proceeds through the formation of thiourea, followed by a sequential addition–dehydration with acylhydrazides. The initial detection of thiourea, which mediates the formation of disubstituted 1,2,4-triazoles, is explained by a plausible mechanism.
Preparation of Arylspiro[2.4]Hept-5-Enes from Aryldibromocyclopropanes via Diallylation and Metathesis Reaction
Authors: Lin Shaw-Tao , Lee Chuan-Chen , Hu Cheng-Kwan
Published: December 2009

A series of arylspiro[2.4]hept-5-enes can be prepared from aryl-diallylcyclopropanes by using Grubbs’ catalyst in good yields.
Unexpected Ring-Opening of a 2-Pyrone Ring in the Synthesis of 3-[(Z)-1-Hydroxy-3-Oxobut-1-Enyl]-2H-chromen-2-One Derivatives Catalysed by Kf-Alumina
Authors: Wang Xiang-Shan , Zeng Zhao-Sen , Zhang Mei-Mei , Shi Da-Qing , Tu Shu-Jiang
Published: December 2009

A series of 3-[( Z)-1-hydroxy-3-oxobutenyl]-2 H-chromen-2-one derivatives were synthesised by an unexpected ring-opening of a 2-pyrone ring reaction of substituted salicylaldehydes, and 4-hydroxy-6-methyl-pyran-2-one in ethyl alcohol at room temperature catalysed by KF-Al2O3. The enol structure of the product not ketone was characterised by 1H NMR, IR and elemental analysis, and enol and ( Z)-structure further confirmed by X-ray diffraction analysis.
Amination of Halopyridines on Kf-Alumina under Microwave Irradiation
Authors: Yang De-Hong , Yang Ben-Yong , Chen Zhen-Chu , Chen Song-Ying
Published: December 2009

A convenient and clean synthesis of halopyridine-2-amines has been provided by amination of halopyridines on KF-alumina under microwave irradiation with good yields.
A Practical Knoevenagel Condensation Catalysed by Imidazole
Authors: Heravi Majid M. , Tehrani Maryam H. , Bakhtiari Khadijeh , Oskooie Hossein A.
Published: December 2009

The Knoevenagel condensation of aldehydes with active methylene compounds is easily carried out in dichloromethane using imidazole as an inexpensive catalyst. The olefinic products were obtained in high to excellent yields.
Unique Keto-Enol Tautomerism in Transition Metal Complexes of Cyanoimidodithiocarbonate
Authors: Nami Shahab A.A. , Siddiqi K.S.
Published: December 2009

A novel potential bidentate sulfur ligand, K2[S2CNHCOCH2CN] and its complexes with first row divalent transition metal ions of the type, M(phen)L, [M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Pd(II), L = S2CNHCOCH2CN and phen = 1,10-phenanthroline] have been synthesised and characterised. On the basis of IR and 1H NMR an enol form is found in the case of ligand and its complexes in the solid state whereas the complexes exist predominantly in the keto form in solution. Electronic spectra and magnetic measurement data indicate that the Ni(II), Cu(II) and Pd(II) complexes have a square-planar geometry but the others have a distorted-tetrahedral structure.
Pd-C/ammonium Formate: A Selective Catalyst for the Hydrogenation of Chalcones to Dihydrochalcones
Authors: Ahmed Naseem , Van Lier Johan E.
Published: December 2009

Pd-C/ammonium formate is a highly efficient catalyst for the selective hydrogenation of chalcones to dihydrochalcones (DHCs). The reaction proceeds under mild conditions and the Pd-C catalyst is recovered without loss of activity.
Three-component Reaction between Dichlorocarbene, Acetylenic Esters and Aromatic Aldehydes. Synthesis of Functionalised Furans
Authors: Anary-Abbasinejad Mohammad , Rostami Navid
Published: December 2009

The zwitterionic intermediate created from the reaction between dichlorocarbene and acetylenic esters is trapped by aromatic aldehydes to afford polyfunctionalised furans in fairly good yields.
Syntheses and Coordination Properties of (Thia)Calix[4]Arenes Bearing Single ω-Quinolin-8-Yl-Oligooxyethylene Pendant
Authors: Zhang Chun-Lei , Jin Yan , Gong Shu-Ling , Zhang Xiao-Feng , Chen Yuan-Yin
Published: December 2009

Four mono-quinolin-8-yl-substituted (thia)calix[4]arenes via oligooxyethylene spacers (1a–b and 2a–b) were synthesised conveniently in one step. Their structures and conformations were characterised by 1H NMR and ESI-MS spectra. Their coordination properties were studied by fluorescence spectra titration in CH3CN. All of them can form stable 1:1 complex with Zn(II) and Mg(II) ions, respectively. The stability constants of thiacalix[4]arene (2a and 2b) derivatives are higher than those of the calix[4]arene analog (1a and 1b).
A selective method for cleavage of N-Troc-protected hydrazines and amines under mild conditions using mischmetal and TMSCl
Authors: Vellemäe Eerold , Lebedev Oleg , Sillard Rannar , Mäeorg Uno
Published: December 2009

The Troc (2,2,2-trichloroethoxycarbonyl) protecting group was efficiently removed under neutral conditions from corresponding protected hydrazines and amines using mischmetal in good to excellent yields. Two new substituted hydrazines were synthesised.
Synthesis of Salicylaldimine Schiff Bases Cobalt (II) Complexes with Benzo-10-Aza-15-Crown-5 Pendant
Authors: Wei Xing-Yue , Jun Long-Liang , Qin Sheng-Ying
Published: December 2009

The azacrown-ether-substituted salicylaldimine Schiff bases ligands HL1–HL5 have been prepared by the condensation of salicylaldehyde (or its derivatives) with the azacrown-ether-containing arylamine from benzo-10-aza-15-crown-5 (BN15C5). The cobalt (II) complexes CoL21–CoL25 are readily synthesised by treatment of HL1–HL5 with cobalt acetate; their structures were characterised by IR, MS, 1H NMR, molar conductance and elemental analysis.
An efficient synthesis of 5′-(4-cyanophenyl)-2,2′-bifuran-5-carbonitrile and analogues
Authors: Ismail Mohamed A.
Published: December 2009

5′-(4-Cyanophenyl)-2,2′-bifuran-5-carbonitrile (6a) was prepared by two approaches. The first approach involves four steps, employs Stille coupling conditions utilising 2-tributylstannylfuran and 5-bromofuran-2-carboxaldehyde to furnish 3a in excellent yield. Oxime formation of 3a followed by acetic anhdride induced-dehydration gives the carbonitrile 4a, which on treatment with N-bromosuccinimide furnished 5a. A subsequent Suzuki coupling of 5a with 4-cyanophenylboronic acid gave 6a in good yield. The second approach used to prepare 6a involves cyanation of bromo-compound 10a with Cu(I)CN in DMF. Oligo-chalcophenes 7a–d were obtained via hexabutylditin-mediated homocoupling of respective brominated precursors 5a–d. Nitro-containing bichalcophenes 14 and 15 were obtained from the 1,4-dicarbonyl compound 13.
Synthesis of 3-substituted coumarins from 2-(acyloxy)arylaldehydes using the TiCl4/R3N reagent system
Authors: Suresh Surisetti , Periasamy Mariappan
Published: December 2009

3-Substituted coumarins are formed in 37–63% yields by the reaction of 2-(acyloxy)arylaldehydes with the TiC4/R3N reagent system. The structure of the compound 2c was determined by single crystal X-ray analysis.
A novel method for the synthesis of α-oximino-6-acylmethylphenanthridines under neutral conditions
Authors: Mehrabi Hossein , Loghmani-Khouzani Hossein , Sadeghi Majid M.
Published: December 2009

A novel method is described for the synthesis of α-oximino-6-acylmethylphenanthridine derivatives (2a–g)B in good to excellent yields based on treatment of 6-acylmethylphenanthridines with isoamyl nitrite (IAN) in DMF without any added acid.
A convenient synthesis of 6-methoxy-4-isopropyl-1-tetralone
Authors: Vera William J. , Banerjee Ajoy K.
Published: December 2009

The transformation of 7-methoxy-1-tetralone into 6-methoxy-4-isopropyl-1-tetralone has been achieved in three steps.
Synthesis and biological study of some new naphtho[2,1-b]furan and related heterocyclic systems
Authors: Badr Mahmoud Z.A. , El-Dean Adel M. Kamal , Moustafa Osama S. , Zaki Remon M.
Published: December 2009

In the reaction of 1-cyano-2-naphthol (4) or its sodium salt with different alkylating agent, the O-alkylated derivatives (5a–d) were produced which underwent ring closure reactions using sodium ethoxide solution to give aminonaphtho [2,1- b]furan derivatives (6a–d). Ethyl 3-aminonaphtho[2,1- b]furan-2-carboxylate (8) was reacted with formamide to afford naphtho[1′,2′: 4,5]furo[3,2- d]pyrimidine (11) derivatives. The produced pyrimidino compound underwent various reactions to synthesise other heterocyclic compounds.
A facile stereoselective synthesis of (E)-1-arylseleno-2-arylsulfanylethenes via hydrozirconation of arylselenoethynes
Authors: Cai Ming-Zhong , Jiang Min-Hua , Li Hai-Gen
Published: December 2009

Hydrozirconation of arylselenoethynes 1 gave ( E)-2-arylselenovinylzirconium(IV) complexes 2, which reacted with arylsulfenyl chlorides 3 stereoselectively to afford ( E)-1-arylseleno-2-arylsulfanylethenes 4 in good yields. ( E)-1-Arylseleno-2-arylsulfanylethenes 4 could undergo a cross-coupling reaction with Grignard reagents stereoselectively in the presence of a nickel-phosphine complex to give ( E)-vinylic sulfides 5.
Synthesis of cyanohydrin trimethylsilyl ethers of diacylferrocences
Authors: Bian Zhan-Xi , Wang Yan-Xue , Zhao Hai-Ying
Published: December 2009

The addition of trimethylsilyl cyanide (TMSCN) to diacylferrocenes [Fc (COR)2] (R = Me, Et, Ph, p-ClC6H4, m-ClC6H4, o-ClC6H4, p-MeOC6H4, Fc = C5H4FeC5H4), catalysed by zinc iodide an acetonitrile provided the corresponding cyanohydrin trimethylsilyl ethers in moderate to high yields. Factors affecting the reaction and yields of adducts were investigated. In addition, the adduct of 1,1′-diacetylferrocene was structurally determined by X-ray crystallography.
New cyclic acetals related to Ambergris and their olfactory evaluation
Authors: Benites Julio , Armstrong Veronica , Cortés Manuel
Published: December 2009

Hemisyntheses of cyclic acetals (11–18) were performed using (–)-polygodial and (+)-confertifolin as chiral starting materials. The acetals obtained were evaluated for their odoriferous properties.
An unusual square planar open-lock shaped copper(II) metallaligand obtained from a hexadentate amine–amide–phenol ligand
Authors: Nanda Prasant Kumar , Ray Debashis
Published: December 2009

The copper(II) complex, [Cu(LH-2)] (4), asymmetrically coordinated by the tetradentate part of, 1,8-bis(2-hydroxybenzamido)-3,6-diazaoctane (L) is reported. Its structure involves a 1-D infinite chain that utilises hydrogen bonding between coordinated side amide carbonyl oxygen and uncoordinated metallaligand amide nitrogen atoms. Further complexation reaction of the metallaligand with [Cu(bpy)(MeOH)2](ClO4)2 gives [Cu2(LH-4)(bpy)] (5).
Dimethoxyboron bromide – a new, efficient, regio- and chemoselective reagent for the conversion of terminal epoxides into bromohydrins
Authors: Roy Chandra D. , Brown Herbert C.
Published: December 2009

Dimethoxyboron bromide, (MeO)2BBr, easily prepared in excellent yield from boron tribromide and trimethyl borate, is a new, efficient, regio- and chemoselective reagent useful for the halogenative cleavage of compounds containing epoxy groups into vicinal bromohydrins in the presence of ether, acetal, ketal, N-oxide, and sulfoxide groups, at low temperatures (–78°C).
Synthesis and spectroscopic characterisation of cobalt(II), nickel(II) and copper(II) complexes with 5-methyl-1-(2′-pyridyl)pyrazole-3-carbohydrazide
Authors: Adhikari Nimairatan , Saha Nityananda
Published: December 2009

The chelating behaviour of the title pro-ligand, 1 (MPyPzCH), is demonstrated by preparation of a range of its distorted-octahedral CoII, NiII and CuII complexes with various counter ions, X (X = Cl, Br, NO3, SCN, BF4, or ClO4). The neutral, tetradentate ligand appears to bind through the pyrazolyl 2N and pyridyl 1′N, amidic oxygen (ketonic form) and the terminal N of the hydrazide residue, respectively. The anions (X) in all cases are coordinated. The ESR spectra of some of the CuII complexes indicate dx2– y2 as ground state.
A facile solid-phase synthesis of Baylis–Hillman products from polymeric selenium reagents
Authors: Huang Bin , Sheng Shou-Ri , Huang Yi-Xiang , Xin Qin , Song Li-Yan , Luo Nian-Hua
Published: December 2009

Treatment of lithio derivatives of polystyrene-supported methyl α-selenopropionate, 2-selenopropiophenone, 1-selenoethyl phenyl sulfone and diethyl 1-selenoethylphosphonate with aldehydes respectively, followed by cleavage from the polymer by oxidation-elimination with 30% hydrogen peroxide efficiently afforded Baylis–Hillman products in good yields and high purities.
Perfluorinated sulfonic acid resin (Nafion-H) catalysed trans-t-butylation of 7-t-butyl-1,3-disubstituted pyrenes; a new route for the preparation of 1,3-disubstituted pyrenes
Authors: Yamato Takehiko , Hu Jian-Yong
Published: December 2009

The perfluorinated sulfonic acid resin (Nafion-H) catalyst is found to be effective in promoting the trans-t-butylation of 7- t-butyl-1,3-dialkylpyrenes to afford the corresponding 1,3-dialkylpyrenes in good yields.
Palladium-catalysed alkynylation of 2- or 3-bromopyridine
Authors: Zhang Weiwei , Cheng Jiang , Huang Zhengxu , Zhou Qingqing , Chen Xunmin , Qian Jianzhu
Published: December 2009

2- or 3-Alkynylpyridines were prepared using a palladium complex, in the absence of copper ions or amines. The mild procedure tolerated a range of 1-alkynes giving 2- or 3-alkynylpyridine in moderate to good yield.
Studies on Dehydro-D-erythro-ascorbic acid 2-arylhydrazone 3-oximes: Conversion into Substituted Triazoles and Isoxazolones
Authors: Sekily Mohamed A. El
Published: December 2009

D- erythro-2,3-Hexodiulosono-1,4-lactone 2- o-bromophenylhydrazone (2) was prepared from dehydro-isoascorbic acid. Reaction of 2 with NH2OH gave the 2-hydrazone-3-oxime (3) which on boiling with Ac2O, gave the triazole derivative 4. The unacetylated triazole derivative 5 was obtained from 3 with Br2–H2O. Treatment of 4 or 5 with ammonia gave the triazole carboxamides 7 and 8 respectively. Vigorous acetylation of 7 and 8 with boiling Ac2O gave tetraacetates, while Ac2O/pyridine gave triacetates. Reaction of 3 with HBr–AcOH gave the 5- O-acetyl-6-bromo-6-deoxy derivative 14, and a controlled reaction of 3 with NaOH, followed by neutralisation, gave the isoxazolone 16.
Stereoselective One-Pot Synthesis of Functionalised Phosphonates by Three-Component Reaction between Trimethylphosphite, Dialkyl Acetylenedicarboxylates and Aldehyde Semicarbazones
Authors: Anary-Abbasinejad Mohammad , Ascarrian Najmeh
Published: December 2009

Three-component reaction between dialkyl acetylenedicarboxylates, trimethylphosphite, and aldehyde semicarbazones leads to functionalised phosphonates in good yields.
Synthesis, Spectroscopic, Magnetic and Volatility Studies of the First Copper(II) Nonaalkoxodistannates
Authors: Agrawal Neetu , Singh Anirudh
Published: December 2009

Derivatives of the types [CCul{Sn2(OR)9}] (R = Et, 1; R = Pri, 2) and [Cu{Sn2(OR)9}2] (R = Et, 3; R = Pri, 4) have been synthesised by the reactions of anhydrous CuCl2 with NaSn2(OR)9 (R = Et, Pri) in 1: 1 and 1: 2 molar ratios in benzene, respectively. The chloro(nonaalkoxodistannato)-copper(II) complexes 1–2 yield, via chloride replacement reactions with a variety of monodentate ( e.g., EtO–, PriO–) or chelating [ e.g., Al(OEt)4–, Al(OPri)4–, Zr2(OPri)9–, and Nb(OPri)6–] ligands, novel heterometallic alkoxides of copper(II). All of the complexes 1–19 are highly moisture-sensitive, coloured solids, that are soluble in typical organic solvents. They are monomeric in benzene solution and are thermally unstable under reduced pressure.
Reductive Cross-Coupling between N-Acylbenzimidazoles and Diarylketones Promoted by Sm/TiCl4
Authors: Du Jingxing , Wang Xiaoxia , Zheng Renwei
Published: December 2009

The reductive cross-coupling reaction between N-acylbenzimidazoles and diarylketones promoted by Sm/TiCl4 was performed in refluxing THF under a nitrogen atmosphere, to give 1,2,2-triaryl ethanones in moderate to good yields.
Thermodynamic Study of Cobalt(III) Schiff Base Complexes in Mixed EtOH/H2O
Authors: Sarvestani Ali Hossein , Asadi Mozaffar , Abbasi Maasuomeh
Published: December 2009

The [Co(Chel)(PBu3)]ClO4.H2O(Chel = dsp, mdsp and ndsp, where dsp = N,N′-disalicylidene-1,2-phenylene diamine, mdsp = 4-methyl-N,N′-disalicylidene-1,2-phenylene diamine and ndsp = 4-nitro-N,N′-disalicylidene-1,2-phenylene diamine), were synthesised and characterised. The equilibrium constants and the thermodynamic parameters of these complexes as acceptors with PBu3, were measured spectrophotometrically for 1: 1 adduct formation in various mixed EtOH/H2O and constant ionic strength (I = 0.1M NaClO4) and at various temperatures T = 288–308 K. The trend of the reactivity of five coordinate Co(III) Schiff base complexes toward PBu3 donor according to the Schiff base ligand is mdsp > dsp > ndsp. The trend of the reactivity of a given Co(III) Schiff base complexes towards PBu3 donor according to the water/ethanol mole fractions is 0.12 > 0.36 > 0.52 > 0.64.
Asymmetric Opening of the Epoxide Ring in Cyclohexene Oxide by Thiophenol Using Homochiral Phosphinamide Catalysts
Authors: Nagasawa Atsushi , Lin Changxue , Wills Martin
Published: December 2009

Enantiomerically pure phosphinamides containing a pendant hydroxyl group catalyse the Al(III)-promoted ring opening of the meso epoxide in cyclohexene oxide with thiophenol in up to 80% enantiomeric excess.
Dialkyl 2H-1-benzothiopyran-2,3-dicarboxylates via Intramolecular Wittig Reaction
Authors: Hekmatshoar Rahim , Javanshir Shahrzad , Heravi Majid M.
Published: December 2009

Reaction of 3-mercaptobenzaldehyde (1) with dialkyl acetylenedicarboxylate in the presence of triphenylphosphine leads to the corresponding 2 H-1-benzothiopyran 2,3-diesters.
1,3-Dipolar Cycloadditions of Substituted Vinylphosphonate with Nitrile Oxides or Nitrones
Authors: Ye Yong , Zhu Xiao-fei , Zhang Chang-shui , Luo Yong , Liu Lun-zu , Zhao Yu-fen
Published: December 2009

1,3-dipolar cycloaddition reactions are among the most important synthetic manipulations allowing the construction of five-membered ring carbocycles and heterocycles. Vinylphosphonates and its analogues have found wide application in organic chemistry during the last two decades and have become very useful for the construction of functionalised organophosphorous compounds. In this report, we have developed a method for the synthesis of β-Substituted vinylphosphonates and the novel structural heterocyclic compound containing a phosphonyl group.
Thermal Intramolecular Diels–Alder Reaction of Furan; Synthesis of Nitrogen Tetracycles, Isobenzofuran and Isobenzothiophene
Authors: Karaarslan Muhsin , Gokturk Ersen , Demircan Aydin
Published: December 2009

Thermal intramolecular Diels–Alder (IMDA) reaction of furan cored compounds has been further investigated; a series of key precursors to the IMDA reaction of furan diene (9a–c) have been prepared via facile alkylation and protection. While the cycloaddition process for (10a–c) was afforded in hot toluene, a commercial microwave (2450 MHz) was used for the synthesis of (12a–b). Treatment of fused oxy- and thio-heterotricycles (12a–b) with borontrifluoride-etherate in dichloromethane at −78°C cleaved epoxy bridge and concomitant aromatisation gave the isobenzo-furan and thiophene (13a–b) in 72–76% yields respectively.
Structural Revision of 19, 20-epoxycytochalasin D and Its Cytotoxic Activity
Authors: Shi Lin-Mei , Zhan Zha-Jun
Published: December 2009

The structure of 19(αH), 20(αH)-epoxycytochalasin D from the fungus Xylaria hypoxylon reported by Espada et al.,1 has been revised to 19(βH), 20(αH)-epoxycytochalasin D (1) by spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. Cytotoxic activity against tumor cell line was assessed for compounds 1, and found to show potent cytotoxic activity against tumor cell line P-388.
Functionalisation of the 1,3-bis(2-pyridylimino)isoindole (BPI) Ligand via Esterification
Authors: Şener M. Kasım , Avcıata Ulvi
Published: December 2009

1,3-bis(2-pyridylimino)isoindolines (BPI) with N-donor groups and long alkyl chains were synthesised by DCC-activated esterification of mercaptoethanol-substituted bis(pyridylimino)isoindole with carboxylic acid derivatives (pyridine-4-carboxylic acid, nonanoic acid). Homoleptic iron(II) complex was synthesised by reaction of BPI with Fe(ClO4)2 in acetone: chloroform. The new compounds were characterised by elemental analyses, FT-IR, 1H NMR, 13C NMR and UV-Vis spectral data.
Three-component One-pot Synthesis and Multinuclear NMR Study of Some β-phosphorus Ylides
Authors: Sabounchei Seyyed Javad , Dadrass Alireza , Jodaian Vida
Published: December 2009

A one-step synthesis of sterically congested phosphorus ylides in moderate to good yields by the reaction of dialkyl acetylenedicarboxylates, NH-acids, dialkyl acetylene dicarboxylates and triphenylphosphine or tri-p-tolylphosphine are reported. The characterisation of these compounds were confirmed by IR, 1H, 31P, and 13C NMR spectroscopy and elemental analysis. NMR spectra showed that some of these compounds (in CDCl3 as solvent) contained two rotamers with unequal populations that equilibrate rapidly at higher temperatures.
Synthesis and Characterisation of the Cd(II) Complex of a Hexadentate(N4O2) Schiff Base Ligand; IR, NMR and Theoretical Studies
Authors: Salehzadeh Sadegh , Golbedaghi Reza
Published: December 2009

A new Cd(II) complex, Cd(L22pysa), prepared from the template condensation of a previously known ligand N(CH2CH2NH2)2(CH2C5H4N), (L22py), salicylaldehyde and [Cd(NO3)2].4H2O in equimolar ratio, has been characterised by IR and variable temperature 1H NMR and 13C NMR spectra. The gas-phase molecular structure of this complex was also studied by ab initio Hartree–Fock and DFT/B3LYP methods.
Microwave-assisted Solvent-free Synthesis of 3-alkyl-6-aryl[1,2,4] triazolo[3,4-b][1,3,4]thiadiazines
Authors: Hui Xin-Ping , Wang Ren-Lin , Zhang Zi-Yi
Published: December 2009

An efficient microwave-assisted solvent-free synthesis of 3-alkyl-6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives is reported. Twelve derivatives have been synthesised in excellent yields in short reaction times.
One-pot Synthesis of Vinyl Phosphonates from 2-hydroxyalkyl Phenyl Selenides with Monoethyl Esters of Phosphonic Acid
Authors: Sheng Shou-Ri , Sun Wu-Kang , Hu Ming-Gang , Liu Xiao-Ling , Wang Qiu-Ying
Published: December 2009

Vinyl phosphonates were prepared with good yields in a one-pot, two-step transformation by Mitsunobu reaction of 2-hydroxyalkyl phenyl selenides with monoethyl esters of phosphonic acid followed by oxidation-elimination.
Configuration of the Major Stereoisomer of Zn/AcOH Reduction Product of 4-oxo-4H-chromene-3-carbaldehyde
Authors: Dey Sankar P. , Dey Dilip K. , Mallik Asok K. , Dahlenburg Lutz
Published: December 2009

Under modified Clemmensen reduction condition 4-oxo-4H-chromene-3-carbaldehyde gave two 1,2-diol products of which the configuration of the major diol was determined by X-ray crystallography
Allylation Reactions of Aromatic Aldehydes and Ketones with Lithium in THF under Ultrasonic Irradiation
Authors: Bian Yan-Jiang , Zhang Jian-You , Li Ji-Tai
Published: December 2009

The allylation reactions of aromatic aldehydes and ketones were carried out in 69–90% yield using Li–THF system under ultrasound irradiation at r.t. for 40 min. The reactions of the same system with stirring gave homoallyl alcohols in 49–67% yield at r.t. for 4 h.
Reaction between 5-Benzylidene-2,2-Dimethyl-1,3-Dioxane-4,6-Dione and Tert-butyl Isocyanide in the Presence of Ethane-1,2-diol or Catechol
Authors: Yavari Issa , Zare Hasan , Mohtat Bita
Published: December 2009

tert-Butyl isocyanide undergoes a smooth reaction with 5-benzylidene-2,2-dimethyl-1,3-dioxane-4,6-diones (benzylidene Meldrum's acids) in the presence of ethane-1,2-diol or catechol to produce functionalised N-tert-butyl-2-(5,7-dioxo-1,4-dioxepane-6-yl)-2-aryl-ethanamides or bis-(2-hydroxyphenyl) 2-[2-(tert-butylamino)-1-aryl-2-oxoethyl]-malonates in good yields.
Highly Regioselective Hydroformylation of Higher Olefins Catalysed by Rhodium-phosphine Complexes in Ionic Liquid Medium
Authors: Lin Qi , Fu Haiyan , Jiang Weidong , Chen Hua , Li Xianjun
Published: December 2009

Hydroformylation of higher olefins was performed efficiently in ionic liquids 1-n-alkyl-3-methylimidazolium p-toluenesulfonate ([Rmim][p-CH3C6H4SO3], R = n-butyl, n-octyl, n-dodecyl, n-cetyl) with the rhodium-phosphine complex Rh-BISBIS (Rh = rhodium complex catalyst precursor; BISBIS = sodium salt of sulfonated 2,2′-bis (diphenylphosphinomethyl)-1,1′-biphenyl) as catalyst. The catalytic system offers excellent regioselectivity towards the linear aldehyde with high activity and chemoselectivity for aldehyde. Furthermore, the ionic liquid containing catalyst can be facilely separated and reused three times without a significant decrease in the activity and selectivity. The ionic liquids [Rmim][p-CH3C6H4SO3] used as the reaction media bring some definitive advantages over the halogen-containing analogues [bmim]BF4 and [bmim]PF6.
Synthesis and Biological Activity of Epoxy Analogues of 3-dehydroteasterone
Authors: Bernardo-Otero Yamilé , Alonso-Becerra Esther , Guerra-Martínez Francisco , Martínez-Massanet Guillermo , Pérez-Martínez Carlos , Coll-Manchado Francisco
Published: December 2009

Two new brassinosteroids analogues containing a 3,6-dione with a 5a-hydroxyl group and also one epoxy ring in the side chain have been synthesised from stigmasterol. Their activity as plant growth promoter has been tested using Radish ( Raphanus sativus) tests.
Synthesis of Functionalised Phosphonates by Three-Component Reaction between Phosphites, Dialkyl Acetylenedicarboxylates and Pyrrole, Indole or Benzotriazole
Authors: Anary-Abbasinejad Mohammad , Rostami Navid , Parhami Azadeh , Hassanabadi Alireza
Published: December 2009

Three-component reaction between dialkyl acetylenedicarboxylates, phosphites, and pyrrole, indole or benzotriazole leads to functionalised phosphonates in good yields.
Co-operative Stabilisation of a 15-component Nanostructure
Authors: Plater M. John , Sinclair James P. , Aiken Stuart
Published: December 2009

2-Amino-4-(4- tert-butylphenylamino)-6-{4-[(4-pyridyl)ethynyl]phenylamino}-1,3,5-triazine was synthesised and mixed with dibutylbarbituric acid in CDCl3 to study rosette formation. The formation of a double decker rosette aggregate was studied by complexation of the pyridyl groups to a zinc containing porphyrin dimer.