bluuebunny/crossref_metadata_2025 huggingface dataset:
Vegetables Spices Fermentation Extract Inhibit NAFLD Development by Attenuation of Steatosis through Suppression of C/EBPα and TNFα mRNA Expression
Authors: Rachmawati Ermin , Machdaniar Maulidya , Kinasih Larasati Sekar , Sargowo Djanggan , Syarifuddin Brillian Putra , Putri Fayza Cinta Rahmadina , Ismail Mahrus
Published: April 2024

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), characterized by inflammation and steatosis, is one of the metabolic problems that trigger serious complications. Statin is usually used for NAFLD therapy, however, statin intolerance and resistance reduce the effectiveness of NAFLD treatment. Therefore, this study was conducted to develop the phytopharmaca against NAFLD by elucidating the anti-inflammatory and steatosis suppression of vegetable spices fermentation extract (VSFE) in rabbits induced with high-fat diet (HFD).METHODS: Twenty New Zealand White rabbits were determined into 4 groups; which were groups receiving standard diet (SD), HFD, HFD and 100 mg/kgBW VSFE, as well as HFD and 200 mg/kgBW VSFE. mRNA expressions of tumor necrosis factor alpha (TNFα) and CCAAT/enhancer-binding protein alpha (C/EBPα) were evaluated. The TNFα concentration was quantified after protein and RNA isolation. Inflammation and steatosis were observed in liver hematoxylin-eosin-stained preparate using microscope.RESULTS: Macrophage cells and hepatic steatosis showed significant decrease in a drug dependent manner. An effective dose of 200 mg/kgBW decreased C/EBPα and TNFα expression to 0.45±0.32 and 0.72±0.29 (p=0.013 and p=0.002, compared to the HFD group), respectively. TNFα inflammatory cytokine concentrations also responded to the administration of 100 mg/kgBW and 200 mg/kgBW doses, with the value of 31.72±10.40 mg/dL and 48.35±7.15 mg/dL (p=0.009 and p=0.002, compared to the HFD group), respectively.CONCLUSION: VSFE might prevent NAFLD by inhibit steatosis and inflammation through suppression of C/EBPα expression and TNFα expression.KEYWORDS: C/EBPα, TNFα, fermentation, steatosis, NAFLD
Investigation of Electronic and Molecular Features of Zn3S3/PEG4000 Nano-Composite Using the DFT Method
Authors: Hraja Manahil , Al Hindawi Aula , Shiltagh Nagham
Published: April 2024

Molecular geometry structures were accurately optimized to low convergence energy thresholds for the Zn3S3 cluster before and after adding Polyethylene Glycol (PEG4000). Density functional theory DFT/ B3LYP calculations with 6-113G (d, p) basis set were employed to investigate structural and electronic properties of Zn3S3/PEG4000 composite. The FTIR spectral lines were analyzed where an agreement of FTIR spectra of titled molecules was evaluated between experimental and theoretical findings of the active peaks of O–H, C–H, C=O, C–O–C, and Zn–S functional groups. The vibrational modes frequencies were systematically analyzed on the distribution basis of potential energy around the range 0–4000 cm-1 and observed 12 modes of vibrations for the Zn3S3 molecule, while 36 modes for the Zn3S3/PEG4000 compound. Frontier high occupied, and low unoccupied molecular orbitals (HOMO&LUMO) were calculated and plotted to obtain the energy gap (E𝒈) resulting from the difference between those orbitals. The promising indicator was obtained at increasing E𝒈 from (4.031 to 4.459) eV after adding PEG4000, pointing out the effect of polymer on the ZnS surface as a capping agent. Additionally, electronic features of the mentioned structures, such as IP, EA, Ef, E𝒈, 𝐶𝑝, χ, η, Ѕ, and ω, were calculated. Finally, the molecular electrostatic potential (MEP) diagram of Zn3S3 and Zn3S3/ PEG4000 and charge densities of isosurface and contour diagrams were estimated, showing the nucleophilic and electrophilic attack of these compounds.
Zastosowanie metod statystycznych do określenia związków pomiędzy minerałami a pierwiastkami jako wprowadzenie do analizy chemostratygraficznej
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Przelaskowska Anna , Zagórska Urszula ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: April 2024

Chemostratygrafia to technika korelacji oparta na danych geochemii nieorganicznej. Polega na dobraniu odpowiednich wskaźników korelacyjnych (pierwiastków / stosunków pierwiastków) pozwalających na wyodrębnienie charakterystycznych poziomów chemostratygraficznych w profilu otworu. Dla prawidłowego doboru wskaźników chemostratygraficznych niezbędne jest ustalenie związków między minerałami a pierwiastkami, ponieważ wiele pierwiastków może wchodzić w skład różnych minerałów. Celem pracy było zastosowanie analizy statystycznej do scharakteryzowania związków między minerałami a pierwiastkami dla próbek piaskowców czerwonego spągowca. W pracy wykorzystano takie metody jak: analiza korelacyjna oparta na interpretacji macierzy korelacji (CC) i wykresach korelacyjnych oraz analiza głównych składowych (PCA). PCA służy do redukcji liczby zmiennych opisujących zjawiska oraz do odkrycia prawidłowości między zmiennymi. Uzyskane wyniki pozwoliły na wyróżnienie kilku grup pierwiastków wzajemnie ze sobą powiązanych, kumulujących się w podobnych minerałach. Wyodrębniono szereg grup związanych z różnymi minerałami, między innymi z minerałami ciężkimi, minerałami ilastymi i dodatkami z płuczki. Pierwiastki ziem rzadkich (REE) rozdzieliły się na dwie grupy: lekkie ziemie rzadkie (LREE) i ciężkie ziemie rzadkie (HREE), co świadczy o tym, że mogą być związane z nieco innymi asocjacjami minerałów ciężkich. Analiza korelacyjna potwierdziła wnioski uzyskane na podstawie analizy PCA, jak również pozwoliła na uszczegółowienie niektórych zależności. Podsumowując, w ramach pracy scharakteryzowano związki pomiędzy pierwiastkami a minerałami w profilu otworu Pł 3. Zaprezentowano właściwy sposób analizy danych geochemicznych, który jest podstawą budowania podziału chemostratygraficznego.
Badania migracji gazu ziemnego w kontekście oddziaływania na środowisko
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Kluk Dorota
Published: April 2024

"Zaostrzenie w ostatnich latach wymogów ochrony środowiska powoduje potrzebę działań zmierzających do minimalizacji niekorzystnego wpływu zjawisk towarzyszących pozyskiwaniu węglowodorów. Jednym z takich zjawisk są ekshalacje gazu ziemnego, które mogą zachodzić zarówno naturalnie, jak i być skutkiem antropopresji wynikającej z eksploatacji węglowodorów. W artykule zaprezentowano badania składu gleby oraz powietrza glebowego z obszarów prowadzenia działalności wydobycia węglowodorów. Na obszarach tych wytypowano lokalizacje, w których zamontowano sondy do poboru powietrza glebowego celem prowadzenia badań monitoringowych jego składu. Podczas montażu sond pobrano próbki gleby z różnych interwałów głębokościowych. Glebę analizowano pod kątem zawartości substancji określonych w obowiązujących przepisach prawnych (Dz.U. z 2016 r. poz. 1395). Ponadto, dla pełnego obrazu wpływu na środowisko gruntowo-wodne, w okolicach złóż węglowodorów przeprowadzono badania toksykologiczne. Do testów toksykologicznych gleb wytypowano organizmy żyjące w środowisku gruntowo-wodnym i wodach słodkich, a kryterium wyboru było ich zróżnicowanie wobec zależności troficznych poszczególnych poziomów – producentów, konsumentów i reducentów. Wybrane do badań toksykologicznych bioindykatory wykorzystane są w komercyjnie dostępnych mikrobiotestach typu ToxKit: Ostracodtoxkit F (konsumenci), Phytotoxkit (producenci) oraz Solid Phase Microtox®SPT (reducenci). Dla właściwej interpretacji uzyskanych wyników równolegle z prowadzonymi badaniami na obszarze potencjalnie zagrożonym wyciekiem gazu wykonywano tożsame badania okolicznego terenu (bez wpływu wydobycia) w celu ustalenia lokalnego tła geochemicznego. Wieloaspektowy monitoring, tj. badanie składu powietrza glebowego, parametrów fizycznych i chemicznych gleby oraz jej oddziaływania na organizmy żywe (bioindykatory) w okolicach potencjalnych źródeł migrującego gazu w odniesieniu do wyników lokalnego tła, umożliwia rejestrację mikrowycieków gazu. Uzyskane rezultaty badań w połączeniu z rozpoznaniem skali ekshalacji gazu ziemnego przyczynią się do podejmowania skutecznych działań na rzecz ograniczenia tego zjawiska do dopuszczalnych standardów stężeń emitowanych zanieczyszczeń.
The Mediator Role of Love Myhts between Narcissistic Personality Traits and Love Styles
Authors: Faraji Haydeh
Published: April 2024

Narcissistic personality traits are associated with relationship conflicts, and the way of perceiving relationships can affect behaviors and attitudes. Therefore, the aim of the study was to investigate the love myths mediator role between narcissistic personality traits and love styles. The research's sample was determined by a simple random sampling method. The sample includes 231 women 187 men in total 418 individuals between the ages of 18-45 (Mean=23.81, Standart Deviation=5.95) who stated that they had been in a romantic relationship and who participated in the study voluntarily. Measurement tools were socio-demographic data form, Narcissistic Personality Inventory, Love Attitudes Scale (Short-Form), and Love Myths Scale. The answers to the surveys were analyzed with the SPSS 25 program. Pearson Correlation Test and PROCESS 3.5 were used. Results indicated that abuse of love and idealization of love myhts mediate between narcissistic personality traits and mania and ludus love style. The results show that love myhts abuse of love and idealization creates a tendency in people with narcissistic personality traits to act like gamer, be careless, and be abusive in romantic relationships. The results of the study might be helpful in finding a solution to narcissistic people's relationship conflicts, raising relationship satisfaction, and by so preventing jealousy, infidelity, and careless or manipulative, aggressive, and abusive attitudes.
Girişimci Kadınlar Kent, Mekân ve Kamusal Alanda Var Olma
Authors: Işık Dilek
Published: April 2024

Bu çalışmada kadınların girişimcilik faaliyetlerinde çalışırken kentte kamusal alanda görünür olma, çalışma hayatı boyunca kentin imkanları ya da sınırlılıkları üzerine girişimci kadınların ekonomik deneyimlerine odaklanmıştır. Girişimci kadınların büyük bir kentte mekânı gündelik hayat ve çalışma hayatları boyunca nasıl algıladıkları, kamusal alanı kullanma biçimleri ekonomik deneyimleriyle ilişkilendirilecektir. Girişimci kadınların faaliyetlerini gerçekleştirdikleri kentin bölgeleri bağlamında özel ve kamusal alan ayrımı boyutuyla ele alınacaktır. Kentsel mekanlarda girişimcilik faaliyetlerinde çalışmanın imkanları ve sınırlılıkları girişimci kadınların İstanbul ilinin seçilmiş bölgelerindeki çalışma yaşamı, sosyal ilişkiler, çalışılan mahallenin nasıl algılandığı ve kentin gündelik yaşam pratikleri içerisinde deneyimlenme süreçleri üzerine yapılan alan araştırmasının verileriyle tartışılacaktır. Girişimci kadınların İstanbul kentine nasıl ve neden yerleştikleri bu şehirde yaşam süreleri, şehre ve çalışılan mahalleye aidiyet duygusuyla ele alınacaktır. Bu araştırmanın bağlamını oluşturan kent yaşamı, kültürel çeşitlilik ve karmaşık yapısıyla girişimci kadınların kimliğini etkileyen önemli boyutlardan bir tanesidir. Girişimci kadınların girişimci kimliği üzerine etki yapan diğer faktörler, toplumsal cinsiyet rolleri ve buna bağlı yaşam tarzlarıdır. Toplumsal cinsiyet rollerinin onların çalışma hayatı üzerindeki etkileri, yaşadıkları mahalle ilişkilerinin etkileri bunların her biri kadınların girişimcilik deneyimlerini etkileyen unsurlardır. Kadın ve erkeklere ilişkin toplumsal kabullerle oluşan rol beklentileri mahalleliyle karşılıklı etkileşim (çatışma, uzlaşma, iş birliği, dayanışma) ve bu etkileşim biçimlerinin onların çalışma deneyimleri açısından nasıl destek veya engel oluşturacağı açısıyla ele alınacaktır.
Doğu Grubu Ağızlarında Kısa Ünlüler
Authors: Kürüm Mesut
Published: April 2024

Genel olarak “ünlüler” ve “ünsüzler” olmak üzere iki gruba ayrılan sesler, belirli özellikler esas alınarak çeşitli sınıflandırmalara tabi tutulmaktadır. Ciğerlerden gelen havanın ses yolunda herhangi bir engele uğramadan çıkmasıyla oluşan ünlüler, dünya üzerindeki ölçünlü dillerde ünsüz sayısına göre daha azdır. İlk yazılı dönemlerinden itibaren ünlü varlığı açısından oldukça zengin bir görünüme sahip Türkçede, ağızlar da buna dâhil edildiğinde ünlü sayısındaki çeşitlilik daha da artmaktadır. Bunun yanında özellikle ağızlardaki fonetik hadiseler, ünlü sayısındaki çeşitliliği belirli oranda artırmıştır.
Dilin tarihini ve gelişimini anlamak için önem arz eden ve ünlü seslerin farklı koşullar altında değişime uğramasıyla meydana gelen birçok hadise vardır. Bu denli çeşitliliğe sahip olan ünlülerle ilgili karşımıza çıkan önemli hadiselerden biri de “ünlülerin boğumlanma süreleri”dir. Türkçenin ünlüleri, boğumlanma süreleri açısından ele alındığında “kısa ünlüler”, “normal süreli ünlüler” ve “uzun ünlüler” olmak üzere üç kategoriye ayrılmaktadır. Bunlardan kısa ünlüler; boğumlanma süresi, normal bir ünlünün boğumlanma süresinden daha kısa olan ünlüler olarak tanımlanmaktadır.
Türkiye Türkçesi ağızları gerek normal süreli ünlüler gerekse uzun ünlüler açısından çok sayıda çalışmayla ele alınmış olmasına rağmen kısa ünlüler açısından detaylı bir araştırmaya konu olmamıştır. Bu çalışmada Türkiye Türkçesinin ana ağız gruplarından biri olan Doğu Grubu ağızlarındaki kısa ünlülü örnekler, ortaya çıkış nedenleriyle birlikte mercek altına alınarak alana katkı sağlamak hedeflenmektedir.
Comment profiter du changement du nouveau programme officiel du français ?: centré sur la liste du vocabulaire de base
Authors:   Société d’Etudes Franco-coréennes, LEE Kyeong-Soo
Published: April 2024

Le nouveau programme officiel du français révisé de 2022 a été publié le 22 décembre 2022. On peut constater qu'il insiste sur la mise en place du système de crédits au lycée. Dans ce cadre, le temps est venu de mettre en place des changements concrets pour attirer !'attention des lycéens sur le français. C'est pourquoi, nous avons d'abord voulu comprendre en profondeur le nouveau programme officiel du français. Pour cela, nous avons examiné la liste du vocabulaire de base figurant sur le programme officiel du français. Et nous avons proposé de profiter de ses avantages pour favoriser la situation d'enseignement/apprentissage du français au lycée.
ANALYSIS OF THE PSYCHOLOGICAL FOUNDATION OF THE IMPLEMENTATION OF LEARNING THE FOUR ARABIC LANGUAGE SKILLS
Authors: Habibah Ihda Filzafatin , Rahmayanti Indah , Holis Holis , Wargadinata Wildana
Published: April 2024

_______Abstract: This analysis is a form of research activity that aims to re-examine a data or actual situation in the hope of increasing understanding and encouraging educators' decision making to understand several areas of psychological foundation before carrying out the learning process. The focus this time is the relationship between the psychological foundation as well as its principles in learning and the relationship between the four Arabic language skills. This research seeks to understand and present from the most specific points to the most specific in the existing theme. The approach used this time is a descriptive-qualitative-based approach using the Document studies and content analysis methods. The results of this study will later provide an overview of the material and content related to how the relationship between the principles of a theory and the psychological foundation of each person with four Arabic language skills in the present and the future.
Interpersonal Regulation Interaction Scale (IRIS): An Adaptation Study in the Context of Psychological Symptom Level and Social Support
Authors: Muslu Özge Nur , Uluç Sait
Published: April 2024

Objective: Interpersonal processes are a significant dimension of emotion regulation, yet studies in this area are quite limited, and the measurement tools used in the Turkish literature are also scarce. Therefore, it is aimed to introduce the Interpersonal Regulation Interaction Scale to the Turkish literature.
Method: The sample of the study consists of n=320 married individuals. The data were collected through surveys. In this study, measurement tools that inquire about emotion regulation, social support, and psychological symptoms were used. The scale's construct validity was assessed with confirmatory factor analysis. Criterion-related validity was tested with Pearson correlation coefficients with other scales, and reliability was calculated using Cronbach α coefficients. Finally, test-retest reliability was tested in a group of 50 individuals.
Results: Confirmatory factor analysis supports the scale's four-factor structure (responsiveness, cognitive support, hostility, physical presence). The Cronbach α values for the Turkish Interpersonal Regulation Interaction Scale are .92 for the responsiveness subscale, .87 for the cognitive support subscale, .75 for the hostility subscale, and .80 for the physical presence subscale. The results of criterion-related validity and test-retest reliability confirm that the Turkish form is a valid and reliable tool, and it is reported that the subscales are associated with psychopathology, difficulties in emotion regulation, psychological symptoms and social support.
Conclusion: This research found that the Interpersonal Regulation Interaction Scale is a valid and reliable measurement tool for the Turkish sample. In conclusion, a significant measurement tool has been introduced for use in research in Türkiye.
The Significance of Innovation Orientation in Firm Performance: Technological Capabilities as A Moderating Role
Authors: Fegada Alfateh , Veres Zoltán
Published: April 2024

Entrepreneurial marketing is considered to be suitable for small businesses. However, innovation orientation as an Entrepreneurial marketing dimension is a critical instrument that small and medium-sized businesses can use to obtain a competitive advantage. Thus, the general objective of this study is to explore and describe the significant relationship between innovation orientation and firm performance in SMEs in Khartoum-Sudan utilizing technological capabilities as a moderating variable. The resource-based view provides the theoretical foundation for this study regarding the effect of innovation orientation on firm performance through technological capabilities. In this manner, our study is quantitative. Reliable with the purpose of this study. Furthermore, our study relied on the “Positivism philosophy”, a deductive approach to theory development. Accordingly, overall, 255 responses were received in responding to our online questionnaire. To analyze the data firstly Principal Component Analysis, Correlation, and Rotation matrix were utilized to test the appropriateness of the study pre-model and check the validity of the questionnaire measurements. secondly, we used Path analysis to examine the significant relationships between study variables. Consequently, the findings confirm both significant and insignificant relationships between innovation orientation and firm performance. Our analysis revealed significant relationships between innovation orientation, technological capabilities, and firm performance indicators such as profitability, sustainability, and customer satisfaction. Moreover, we found that technological capabilities play a crucial moderating role in enhancing the effects of innovation orientation strategy on firm performance. Anyhow, these results confirmed the partial support of the study’s hypotheses.
Exploration of the Relationship between Organizational Culture and Its Performance in the Bangladeshi Microfinance Sector with Organizational Innovation as a Mediating Factor
Authors: Akhter Parul , Chaity Naznin Sultana
Published: April 2024

This study aims to explore the relationship between organizational culture and organizational performance, whereas organizational innovation is focused on as a mediating variable in the microfinance organization in Bangladesh. The current study looks at organizational culture, covering mission, employee involvement, and adaptability. Organizational performance is defined by four variables: productivity, effectiveness, efficiency, and quality, while organizational innovation is determined by four variables: innovation strategy, intellectual capital, new process development, and new product development. The study used a self-administered questionnaire using a five-point Likert scale. The data were collected from 300 middle and senior managers and considered Bangladesh's top fifty microfinance organizations. The hypotheses and connections between the constructs were empirically tested using structural equation modeling (SEM) along with the partial least squares (PLS) approach. The findings indicate that organizational culture positively affects organizational innovation and firm performance. Organizational innovation has a strong positive impact on organizational performance. On the other hand, organizational innovation mediates the indirect relationship between organizational culture and performance. The study's findings indicate that executives, entrepreneurs, and policy developers should focus on business culture and organizational innovation in addition to increasing efficiency and maintaining a competitive advantage.
Hamas-Israel War: A Brief Analysis of First Two Phases of War
Authors: Bordas Maria
Published: April 2024

At the end of 2023, the Middle East experienced some new challenges. Among these new challenges, one of the most important of them all is the Hamas-Israel war. After almost four months of war and no end in sight, there are now growing questions about whether Israel will be able to accomplish its stated goals in Gaza. The brutality of the Hamas’s attack on October 7, the extent of the cruel massacre, shocked both the Israeli society and foreign public opinion. To better understand the factors of Hamas's operational success, the strategic surprise attack on Israel from Gaza, on October 7, 2023, needs a thorough analysis to understand all its political, intelligence, and operational failures aspects. It goes without saying that many elements of Hamas's brutal but largely successful attack are still unknown. Taking this into account, this paper focuses on only three elements of the ongoing war. Firstly, based on the qualitative methodology of research, this study evaluates and highlights the political background of the bloodiest attack in modern Israel's history which happened on October 7, 2023. Secondly, using the research methodology of data collection and analysis, this paper seeks to answer the still open-ended question, how was Hamas able to attack a country which operates one of the best intelligence organizations in the world by an extreme surprise? Finally, by using the narrative and historical models of qualitative research and the available data, this paper focuses on assessing the first and second phases of the war. Furthermore, the study formulates conclusions regarding the expected directions of change in the Israeli security system and some aspects of regional security implications of the ongoing Hamas-Israeli conflict. The potential result of the current paper is to present the reasons for the ongoing Gaza conflict based on the historical background. In addition, it provides a primary analysis, based on currently available information, of the first two phases of the obviously protracted Hamas-Israel conflict for the benefit of the community of researchers, scholars, and academics.
Gothic Experiences in Jane Eyre, Wuthering Heights, and The Tenant of Wildfell Hall
Authors: Tine Etienne Pathe
Published: April 2024

This paper thoroughly analyses the theme of the gothic imagination in the works of Charlotte, Emily, and Anne Bronte, specifically in Jane Eyre, Wuthering Heights, and The Tenant of Wildfell Hall. The novels portray romantic and sublime scenes with elements of terror, horror, and the uncanny, which intensify the expression of the gothic feelings experienced by the characters. The study also explores women's suffering in the context of gothic thought. Various factors inherent to the gothic genre contribute to the 19th-century readers’ fascination with the supernatural and thrilling emotions. This work explores gothic experiences depicted in novels using gothic tropes and critical approaches such as Marxism, feminism, or psychoanalysis. The use of the framing narrative technique remains a distinctive aspect of this study which worthily includes The Tenant of Wildfell Hall, a book that many critics have wrongly overlooked when interpreting the Bronte sisters’ novels in the light of the gothic trend. The analysis considers the common gothic features that characterize the novels, rather than treating them separately. This reinforces and enhances the scope of the analysis of the Gothic vision of these Victorian novelists.
Cajanus cajan Leaves and Ginger Increase Antioxidant Defence in Pancreatic Diabetic Rats: An Immunohistochemical Study
Authors: Wresdiyati Tuti , Cahyani Bella Dinar Fauqii , Hamzah Alfarisi , Sa'diah Siti , Astawa Made
Published: April 2024

Hyperglycemia in diabetes mellitus results in stress oxidative condition. This study aims to analyze the antioxidant defence in pancreatic experimental-diabetic rats treated with a combined extract of Cajanus cajan leaves and ginger, using an immunohistochemical technique for copper, zinc – superoxide dismutase (Cu,Zn-SOD). A total of 25 male Sprague Dawley rats were used in this study. The rats were randomly divided into five groups; normal control group (NC), diabetic group (DM), two groups DM treated with a different dose combination of Cajanus cajan leaf extract and ginger extract (DME and DMF), and DM treated with glibenclamide (DMG). This study used 110 mg/kg BW alloxan induction to obtain diabetic conditions, and the treatments of the extract were conducted for 28 days. The pancreatic tissues were processed using the paraffin standard method and an immunohistochemical technique using monoclonal antibody Cu,Zn-SOD. The results showed that a combination of Cajanus cajan leaf extract and ginger extract lowered the level of blood glucose, increased body weight, and increased the level of Cu,Zn-SOD content in pancreatic tissues of experimental-diabetic rats. This study concluded that combining Cajanus cajan leaf extract and ginger extract increased antioxidant defence in pancreatic organs of experimental-diabetic rats.
FALKE-eR: Eine konzeptionelle und empirische Studie zur Förderung der adaptiven Erklärkompetenz bei angehenden Religionslehrkräftenen
Authors: Boukrayâa Trabelsi Kathrin
Published: April 2024

Der Beitrag beschreibt die religionsdidaktische, empirische Teilstudie des fächerübergreifenden Forschungsprojekts FALKE-e, das im Rahmen des BMBF-Projekts KOLEG2 der Universität Regensburg durchgeführt wird. Die Studie widmet sich (fach-)didaktischen Professionalisierungspraktiken, insbesondere der Förderung der Erklärkompetenz angehender Lehrkräfte, und begleitet unter anderem die Entwicklung eines stark praxisorientierten universitären Lehrformats. In dessen Rahmen werden Studierende in ihrer adaptiven und adressatenorientierten Erklärkompetenz gefördert, sowie in ihrer Kompetenz, die eigenen Erklärungen anhand von Videographien in fundierter Weise zu reflektieren. Das speziell zu diesem Zweck entwickelte Seminarkonzept, das sich auch im Studiendesign widerspiegelt, erlaubt eine differenzierte Erhebung, Messung und Auswertung der Kompetenzentwicklung, die sich durch unterrichtliche Praxiserfahrung bereits während der ersten Ausbildungsphase ergibt.
O ensino de startups de software em cursos da área de computação
Authors: Estevo Cristiane Alves , Leal Gislaine Camila Lapasini , Balancieri Renato , Oliveira Júnior Edson Alves de
Published: April 2024

O ensino de startups de software aborda circunstâncias sobre sua criação, condições de operação, transformação para um modelo de negócios e planos de fundação. Este artigo buscou identificar as ferramentas, modelos, métodos e metodologias que são aplicados no ensino e aprendizagem de startups de software para alunos de graduação nas instituições de ensino superior. A partir de um Mapeamento Sistemático da Literatura (MSL) foram selecionados 32 estudos. O MSL resultou na descoberta das práticas empregadas tais como a Aprendizagem Experiencial, o Estudo Empírico e o Método Experimental. A partir disso, algumas suposições e direcionamentos foram delineados e apresentados buscando melhorar a qualidade do ensino, motivação dos alunos e o alinhamento entre a academia e o mercado de trabalho.
Explorando a relação entre recursos educacionais usados na educação superior a distância e a evasão
Authors: Santos Gleice Louise Garcia Costa dos , Leite Letícia Lopes
Published: April 2024

Este trabalho é um estudo de caso exploratório com abordagem qualitativa que analisou a relação entre o uso de recursos educacionais em ambientes virtuais de aprendizagem, na Educação Superior a distância, e as taxas de evasão. O estudo realizado justifica-se em virtude da terceira maior causa da evasão, originária dentro do próprio sistema educacional, estar relacionada com o uso da plataforma. O uso de Tecnologias Educacionais, síncronas e assíncronas, pode influenciar nos índices de evasão. Os resultados indicam que cursos com mais recursos tiveram maiores taxas de evasão, enquanto aqueles com menos recursos tiveram taxas menores. Por isso, apresenta-se uma análise crítica dos resultados da pesquisa, destacando as implicações e as contribuições do estudo.
Formação e conhecimentos de docentes universitários para a integração de tecnologias digitais no ensino remoto
Authors: Will Daniela Erani Monteiro , Espíndola Marina Bazzo de , Cerny Roseli Zen , Erdmann Alacoque Lorenzini , Schmidt Catiele Raquel , Santos José Luís Guedes dos , Lorenzini Elisiane
Published: April 2024

O artigo apresenta uma reflexão acerca das ações formativas de docentes universitários no contexto de ensino remoto, a partir da necessidade de integrar as tecnologias digitais ao currículo do ensino superior. Para isso, realizamos um estudo de cunho exploratório em uma universidade pública brasileira, por meio de um questionário que obteve respostas de 334 professores. Analisamos como eles consideram seus conhecimentos para a atuação com tecnologias digitais e de que forma buscaram novas aprendizagens docentes diante da situação de ensino remoto. Os resultados apontam que os professores realizaram as formações oferecidas pela universidade, ao mesmo tempo em que buscaram conhecimentos por conta própria, em fontes diversificadas. Como formação autônoma, destacam-se as trocas entre os pares, bem como com os estudantes.
Tecnologia Educacional na era da IA
Authors: Oliveira Anderson Soares Furtado , Isotani Seiji , Pinto Ig Ibert Bittencourt Santana
Published: April 2024

Este artigo apresenta um mapeamento sistemático de literatura (MSL) que classifica os Sistemas Tutores Inteligentes (STI) por áreas de conhecimento, com o objetivo de compreender sua distribuição e aplicação entre 1956 e 2023. Dos 907 casos de aplicações de STI mapeadas, 80% estão concentrados em seis áreas: Matemática, Letras, Ciência da Computação, Medicina, Engenharia Elétrica e Física. Por outro lado, é preocupante observar que 26 áreas de conhecimento não apresentaram qualquer registro de aplicações de STI. Essa ausência sugere uma lacuna de pesquisa e aplicação em uma ampla gama de disciplinas. A análise das publicações mais citadas nas principais áreas de conhecimento revelou obras-chave que influenciaram o campo. As implicações práticas incluem oportunidades para melhorar o aprendizado e o treinamento em diversas disciplinas.
Optimization of Transformative Leadership to Enhance Organizational Performance: Policing Strategic Analysis at Industrial Revolution 4.0 Era to Maintain Security and Public Order
Authors: Latif Muh. Wahyudin , Dwilaksana Chryshnanda , Nasri Nasri , Wardana Gusde
Published: April 2024

Abstract
The Bojonegoro Resort Police, a middle manager in the Indonesian National Police, proactively adapts to the Fourth Industrial Revolution's challenges, marked by VUCA (Volatility, Uncertainty, Complexity, and Ambiguity). They prioritize staying informed about developments and taking initiative. Strategies for security and public order maintenance, including crime prevention and increased surveillance, are effectively planned and implemented. Qualitative field research explores how transformative leadership optimizes policing and performance. Findings reveal: 1) Leaders model idealized influence and inspire a shared vision; 2) They provide inspirational motivation; 3) Leaders foster intellectual stimulation by promoting skill development and critical thinking; 4) Individualized consideration is shown through active delegation and control measures. In conclusion, the Bojonegoro Resort Police's proactive, transformative leadership helps them navigate the Fourth Industrial Revolution's challenges, enhancing organizational performance in maintaining security and public order.
Combination of stem cell and repetitive transcranial magnetic stimulation in acute ischaemic stroke as a promising treatment: A case report
Authors: Danuaji Rivan , Hambarsari Yetty , Hamidi Baarid Luqman , Hutabarat Ervina Arta Jayanti , Tedjo Raden Andi Ario , Fairuzya Azmi Farah , Savitri Martha Oktavia Dewi
Published: April 2024

Stroke is a major contributor to long-term disability and its incidence continues to rise annually. This case report aimed to explore the promising benefits of combining stem cell therapy with repetitive transcranial magnetic stimulation (rTMS) in managing acute ischaemic stroke patients. A 62-year-old male presented with left-sided hemiparesis and hemineglect, as well as a cognitive disturbance in the attention domain. His medical history included uncontrolled hypertension over decades and diabetes mellitus for five years. A non-contrast head computed tomography (CT) scan revealed infarction in the right middle cerebral artery (MCA), with an initial National Institutes of Health Stroke Scale (NIHSS) of 13 upon admission to the Emergency Room. The infection and tumour markers were conducted to confirm no contraindication in this patient receiving stem cell therapy. Following the acute phase, the patient underwent a comprehensive treatment regimen involving both stem cell therapy and serial rTMS. Clinical assessments included NIHSS, Barthel Index, and Fugl-Meyer Assesement to evaluate neurological deficits. Additionally, the Montreal Cognitive Assessment-Indonesian version (MoCA-INA) assessment, electroencephalography examination and motor threshold were conducted. The results of this case report revealed noteworthy improvements in NIHSS, motoric strength, and cognitive function post-treatment. In this case report, improvement in clinical outcomes was obtained in the form of motor strength and higher cortical function. Stem cell therapy combined with rTMS has good potential in treating various neuroregenerative and rehabilitative aspects in ischaemic stroke patients.
Non-communicable disease risk factors and Covid-19 antibody levels after vaccination
Authors: Wea Brigitta Yuliana , Hananta Linawati , Astiarani Yunisa
Published: April 2024

Background: Non-communicable diseases (NCDs) have been identified as predictors of the severity of Coronavirus Disease 2019 (Covid-19). Some factors like smoking, alcohol consumption, and physical inactivity, which are associated with NCDs, may potentially hinder the efficacy of vaccines, reducing their ability to prevent the severity and complications of infectious diseases such as the Covid-19. Objective: This study investigated the NCD, risk factors associated with the levels of quantitative antibodies after the second Covid-19 vaccination.Methods: A cross-sectional study was conducted at a Covid-19 vaccination centre in Jakarta. Ninety subjects, aged ≥18, completed demographic and NCDs risk factor questionnaires. Blood samples were collected and analysed by using the electro chemiluminescence immunoassay analyser (ECLIA) method to measure quantitative antibody levels 30 days after 2nd Covid-19 vaccination. The bivariate analysis was performed to explore associations among the variables. The logistic regression was subsequently performed to identify the factors that remained independent in influencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody status. Results: The mean value of antibody level in this study was 191 U/ml. The results indicated that 35.5% (n=32) of respondents had SARS-CoV-2 antibody levels below average. The regression results suggested that the odds of having higher antibody levels were reduced for individuals with hypertension (Adjusted Odd Ratio [AOR] = 0.74, p value = 0.022), diabetes (AOR = 0.82, p value = 0.038) comorbidities accompanied with smoking (AOR = 0.55, p value = 0.044), drinking alcohol (AOR = 0.92, p value = 0.030), and low physical activity levels (AOR = 0.67, p value = 0.043). Conclusion: The study found that 35.5% of participants had SARS-CoV-2 antibody levels below the average. Factors such as hypertension, diabetes, comorbidities with smoking, alcohol consumption, and low physical activity were associated with reduced odds of higher antibody levels.
Prevalence of alcohol use and depressive/anxiety symptoms among patients of opioid agonist treatment programs in Ukraine
Authors: Klymchuk Vitalii , Gorbunova Viktoriia , Ivanchuk Iryna
Published: April 2024

This cross-sectional study explores the prevalence of alcohol use problems, depression/anxiety symptoms, and suicidal ideations among patients of the opioid agonist treatment (OAT) programs in Ukraine and their co-occurrence. AUDIT, Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) were used to measure mental health conditions. In addition, the number of missed visits on site for substitute medication for the last month was counted, and blood alcohol levels were recorded (Drager Alcotest 6820, Draeger, Lübeck, Germany). Data were collected from October 2021 to January 2022 (before the full-scale Russian invasion) based on OAT centers in Kyiv, Sumy, and Lviv. The sample size was 999 patients. The overall rate of signs of alcohol-related problems (AUDIT), depression symptoms (PHQ-9), and anxiety symptoms (GAD-7) in the sample was 3.8 (SD 5.424), –7.42 (SD 5.336), and 5.058 (SD 4.264), respectively. For alcohol-related problems, 16.4% of the participants reported harmful drinking (one-month prevalence). Depression symptoms from moderate to severe were found in 26.73% of cases, and generalized anxiety symptoms from moderate to severe levels were found in 14.71% of patients (2-week prevalence). The 2-week suicide ideation prevalence was 24.9% (a quarter of all OAT patients). General co-occurrence of depression and anxiety symptoms was equal to 13.31% of all patients who participated in the study (32.13% of all patients having depression or anxiety symptoms). There was an increase in the general co-occurrence ratio with an increase in the severity of alcohol-related problems from 10.66% to 54.55%.
Development of a Mock-up of a Smart Insole Using FSR and ADXL345
Authors: LELE ABHISHEK MANISH , WAGHOLE DNYANESHWAR , DHATRAK PANKAJ
Published: April 2024

This research article describes the creation of a mock-up for a Smart Insole prototype that employs Force Sensitive Resistors (FSRs) and an ADXL345 accelerometer. The mock-up is an early step towards realising the concept and functionality of the planned Smart Insole system. The key factors in the mock-up's design, integration, and testing are highlighted, with a focus on the iterative refining and optimisation process. The mock-up, which was carefully planned and implemented, highlights the practicality and possible applications of Smart Insole technology in healthcare, sports performance measurement, and rehabilitation. The paper outlines the development process and implementation of a "Smart Insole" utilizing Force Sensitive Resistors (FSR) and the ADXL345 accelerometer. The project aims to create an innovative wearable technology solution for monitoring foot biomechanics and enhancing human performance. The Smart Insole prototype integrates FSRs strategically placed on the insole to capture pressure distribution across the foot, along with an ADXL345 accelerometer to track foot orientation and movement. Through a combination of hardware integration, firmware development using Arduino IDE, and visualization using Processing application, the Smart Insole offers real-time monitoring and analysis of gait dynamics, pressure distribution, and foot movement.
Concrete Decisions: How Psychological Distance Influences Willingness to Engage in Risky COVID Behavior
Authors: Williams Ceridwen , Rauwolf Paul , Boulter Matt , Parkinson John A.
Published: April 2024

Pandemics, and other risk-related contexts, require dynamic changes in behavior as situations develop. Human behavior is influenced by both explicit (cognitive) and implicit (intuitive) factors. In this study, we used psychological distance as a lens to understand what influences our decision-making with regards to risk in the context of COVID-19. The study was based on the rationale that our relational needs are more concrete to us than the risk of the virus. First, we explored the impact of social-psychological distance on participants’ risk perceptions and behavioral willingness. As hypothesized, we found that close social relationships of agents promoted willingness to engage in risky behavior. In the second phase, we tested an intervention designed to increase the concreteness of information about virus transmission as a mechanism to mitigate the bias of social influence. We found that the concreteness intervention resulted in significantly reduced willingness to engage in risky behavior. As such, communications aimed at changing the behavior of citizens during times of increased risk or danger, should consider conceptually concrete messaging when communicating complex risk, and hence may provide a valuable tool in promoting health-related behavior.
A Comprehensive Review of MAV/06 Varicella Vaccines: Safety, Immunogenicity, and Effectiveness
Authors: Shin Younchul , Ryu Hyunji , Kim Gwanglok , Yang Shinha , Lee Jaewoo , Choi BongKyoo
Published: April 2024

Varicella (chickenpox) is one of the most common infectious diseases in preschool children and can be prevented by immunization. While immunization program promotes higher vaccine coverage, there are still challenges with implementing vaccination programs particularly in low-income countries. Economic barriers can increase inequality in vaccination, which highlights the importance of distributing cost-effective varicella vaccines. Varicella vaccines have been developed with two main Varicella-Zoster Virus (VZV) strains globally: MAV/06 and Oka strains. Most of the vaccines are based on the Oka strain, while MAV/06 strain vaccines were exclusively developed by GC Biopharma. Although more than 30 million doses of MAV/06 vaccines as cost-effective vaccines have been distributed internationally, there is no comprehensive review on safety, immunogenicity, and effectiveness of MAV/06 vaccines in the literature. This paper aims to summarize and present more than 30 years of accumulated evidence from research on safety, immunogenicity, and effectiveness of MAV/06 vaccines. We expect that MAV/06 vaccines as cost-effective varicella vaccines make a significant contribution to improving global public health and health equality in children.
When You Think of and Identify Yourself as a Nurse, You Will Become More Deontological and Less Utilitarian
Authors: Zheng Mufan , Zhao Junhua
Published: April 2024

This study aims to examine how the activation of nursing roles and professional identification as a nurse can influence moral judgments in terms of deontological and utilitarian inclinations. In Study 1, a priming technique was used to assess the impact of activating the nursing concept on moral reasoning. Participants were randomly assigned to either a nursing prime or neutral prime condition. By using a scrambled-sentences task, participants were prompted to think about nursing-related or neutral thoughts. Following the priming task, participants were asked to respond to 20 moral dilemmas. The process dissociation approach was employed to measure the degree of deontological and utilitarian tendencies in their moral reasoning. In Study 2, participants completed the nursing profession identification scale and the moral orientation scale before engaging in moral judgments similar to those in Study 1. The findings revealed that priming the concept of nursing roles resulted in an increase in deontological clinical inclinations, while having no significant effect on utilitarian inclinations. Additionally, a positive correlation was observed between identification with the nursing profession and deontological clinical inclinations, whereas a negative correlation was found with utilitarian inclinations. Deliberation orientation acted as a complete mediator in the relationship between nursing professional identification and deontological tendencies, and as a partial mediator for utilitarian tendencies.
Transmission Mechanism of Influencing Factors in the Promotion and Application of Whole Process Engineering Consulting
Authors: Huang Xu , Hu Qing Bo , Zhou Wen Bin , Yang Peng , Liu Fang Ru , Zhou Wen
Published: April 2024

To facilitate the promotion and application of the whole process engineering consulting (WPEC) model, the transmission mechanism of influencing factors in WPEC's promotion and application is investigated. It identifies and categorizes the influencing factors within the framework of "external environment-project factors-stakeholders", systematically organizing and summarizing ten primary categories and thirty-eight secondary influencing factors of WPEC's promotion and ap-plication. Utilizing the complex network analysis method, a network of influencing factors in the promotion and application of WPEC is constructed. The network is then converted into three binary networks based on weight, which are subjected to structural analysis and motif analysis. On this basis, the transmission mechanism of influencing factors in WPEC's promotion and applica-tion and its causations are explored.
Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review
Authors: Sandes Valcieny , Figueras Albert , Lima Elisangela Costa
Published: April 2024

The spread of antimicrobial resistance (AMR) is a global challenge. Close and continuous surveillance for quick detection of AMR can be difficult, especially in remote places. This narrative review focuses on the contributions of pharmacovigilance (PV) as an auxiliary tool for identifying and monitoring the ineffectiveness of, resistance to, and inappropriate use of antibiotics (ABs). The terms “drug ineffective,” “therapeutic failure,” “drug resistance,” “pathogen resistance,” and “multidrug resistance” were found in PV databases and dictionnaires, and denote ineffectiveness. These terms cover a range of problems that should be better investigated because they are useful in warning about possible causes of AMR. “Medication errors,” especially those related to dose and indication, are highlighted in the literature, suggesting inappropriate use of ABs. Hence, the included studies show that the terms of interest related to AMR are not only present but frequent in PV surveillance programs. This review illustrates the feasibility of using PV as a complementary tool for antimicrobial stewardship activities, especially in scenarios where other resources are scarce.