bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Area in Youth
Authors: Schmitt J. Eric , Neale Michael C. , Clasen Liv S. , Liu Siyuan , Seidlitz Jakob , Pritikin Joshua N. , Chu Alan , Wallace Gregory L. , Lee Nancy Raitano , Giedd Jay N. , Raznahan Armin
Published: March 2019

The genetics of cortical arealization in youth is not well understood. In this study, we use a genetically informative sample of 677 typically developing children and adolescents (mean age 12.72 years), high-resolution MRI, and quantitative genetic methodology to address several fundamental questions on the genetics of cerebral surface area. We estimate that >85% of the phenotypic variance in total brain surface area in youth is attributable to additive genetic factors. We also observed pronounced regional variability in the genetic influences on surface area, with the most heritable areas seen in primary visual and visual association cortex. A shared global genetic factor strongly influenced large areas of the frontal and temporal cortex, mirroring regions that are the most evolutionarily novel in humans relative to other primates. In contrast to studies on older populations, we observed statistically significant genetic correlations between measures of surface area and cortical thickness (rG= 0.63), suggestive of overlapping genetic influences between these endophenotypes early in life. Finally, we identified strong and highly asymmetric genetically mediated associations between Full-Scale Intelligence Quotient and left perisylvian surface area, particularly receptive language centers. Our findings suggest that spatially complex and temporally dynamic genetic factors are influencing cerebral surface area in our species.

SIGNIFICANCE STATEMENTOver evolution, the human cortex has undergone massive expansion. In humans, patterns of neurodevelopmental expansion mirror evolutionary changes. However, there is a sparsity of information on how genetics impacts surface area maturation. Here, we present a systematic analysis of the genetics of cerebral surface area in youth. We confirm prior research that implicates genetics as the dominant force influencing individual differences in global surface area. We also find evidence that evolutionarily novel brain regions share common genetics, that overlapping genetic factors influence both area and thickness in youth, and the presence of strong genetically mediated associations between intelligence and surface area in language centers. These findings further elucidate the complex role that genetics plays in brain development and function.
Differential Brain Mechanisms of Selection and Maintenance of Information during Working Memory
Authors: Quentin Romain , King Jean-Rémi , Sallard Etienne , Fishman Nathan , Thompson Ryan , Buch Ethan R. , Cohen Leonardo G.
Published: March 2019

Working memory is our ability to select and temporarily hold information as needed for complex cognitive operations. The temporal dynamics of sustained and transient neural activity supporting the selection and holding of memory content is not known. To address this problem, we recorded magnetoencephalography in healthy participants performing a retro-cue working memory task in which the selection rule and the memory content varied independently. Multivariate decoding and source analyses showed that selecting the memory content relies on prefrontal and parieto-occipital persistent oscillatory neural activity. By contrast, the memory content was reactivated in a distributed occipitotemporal posterior network, preceding the working memory decision and in a different format than during the visual encoding. These results identify a neural signature of content selection and characterize differentiated spatiotemporal constraints for subprocesses of working memory.

SIGNIFICANCE STATEMENTOur brain selects and maintains information during short time windows in a way that is essential to reasoning and learning. Recent advances in multivariate analysis of brain activity allowed the characterization of brain regions that stores the memory. We applied multivariate analysis to time-resolved brain signals to characterize the spatiotemporal signature underlying these subprocesses. The selection of information relies on sustained oscillatory activity in a network that includes the ventrolateral prefrontal cortex while memory content is transiently replayed in an occipitotemporal network that differs from encoding. Our results characterized differentiated spatiotemporal activity underlying encoding, selection, and maintenance of information during working memory.
The Community Satisfaction and Participation of the Health Planning Process in Primary Health Care
Authors: Sriatmi Ayun , Fatmasari Yunila
Published: March 2019

PHC as a public service institution is obliged to comply with the public service standard regarding with the community participatory principle. This research aimed to describe the community satisfaction and participation level in the PHC planning. Descriptive qualitative with 14 informants from 4 PHC in districts of Semarang and Kudus. Data were collected by indepth interview and analyzed with content analysis. Communities are satisfied with the PHC service because of the good service and uncomplicated procedure, which has impact to increase the daily visits. This situation makes queue time longer and the fatigue level of the officer tends to decrease the satisfaction. Communities have been involved in the planning mechanism, although only limited to the situational analysis phase. The Health Office is expected to facilitate the addition of PHC personnel and PHC also have to fulfill the need of human resources through the plans that have been done.
MİSYON VE VİZYON İFADELERİNİN DEĞERLENDİRİLMESİ: TÜRK YİYECEK-İÇECEK İŞLETMELERİNDE BİR ARAŞTIRMA
Authors: ERDEN AYHÜN Sena , ÇAVUŞGİL KÖSE Bilge
Published: March 2019

İyi tasarlanmış vizyon ve misyon ifadeleri, stratejinin oluşturulması, uygulanması ve değerlendirilmesi için gereklidir. Ne yazık ki güçlü bir işletme vizyonu ve etkili bir işletme misyonu geliştirmek stratejik yönetimde en çok göz ardı edilen görevler arasında yer almaktadır. Bu çalışmanın amacı, yiyecek-içecek işletmelerinin vizyon ve misyon bildirgelerini ideal vizyon ve misyon bileşenleri açısından analiz etmektir. Bu kapsamda fast-food sektöründe yer alan 10 yiyecek içecek işletmesinin misyon ifadeleri Pearce ve David (1987)’ in belirlediği kapsamlı bir misyon beyanatının dokuz bileşeni doğrultusunda, vizyon ifadeleri ise Kantabutra (2008)’in belirlediği vizyon karakteristiklerinin yedi bileşeni doğrultusunda içerik analizine tabi tutulmuştur. Araştırma sonuçları işletmelerin misyon ifadelerinde eksiklikler olduğunu ortaya çıkarmıştır. Diğer yandan işletmelerin büyük çoğunluğunun vizyon ifadelerini arzu edilen şekilde düzenleyebildiği görülmüştür.
AN EXAMINATION ON THE IMPACT OF OUTSOURCING ON SUSTAINABLE SUPPLY CHAIN AND BUSINESS PERFORMANCE
Authors: ÇAĞLIYAN Vural , GELMEZ Emel , DİLEK Minenur Sezer
Published: March 2019

As a requirement of competitiveness, businesses procure those goods and services which are beyond their own fields of activity from specialized businesses. Based on this requirement, examination of the effect of outsourcing, one of the crucial instruments for businesses in gaining competitive advantage, on sustainable supply chain performance and business performance, is of importance in terms of bringing a point of view on the dimensions of the ongoing competition in sectoral sense and enabling the businesses to assess their own structures. In this context, the effect of outsourcing by businesses operating in food industry in the province of Konya on sustainable supply chain performance and business performance was examined in this study. Structural equation modeling was utilized to analyze the correlation between the variables. While no statistically significant correlation could be determined between outsourcing and sustainable supply chain perforrmance, it was found out that a statistically significant correlation existed between sustainable supply chain performance and business performance as well as between the outsourcing and business performance.
Serum metabolomic analysis of the effect of exercise on nonalcoholic fatty liver disease
Authors: Li Jia , Zhao Yan , Huang Caoxin , Chen Zheng , Shi Xiulin , Li Long , Chen Zhong , Li Xuejun
Published: March 2019

Objective

Exercise benefits people with nonalcoholic fatty liver disease (NAFLD). The aim of this study was to identify a panel of biomarkers and to provide the possible mechanism for the effect of exercise on NAFLD patients via an untargeted mass spectrometry-based serum metabolomics study.

Methods

NAFLD patients were classified randomly into a control group (n = 74) and a 6-month vigorous exercise (n = 68) group. Differences in serum metabolic profiles were analyzed using untargeted ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) technology. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to validate the differences between these two groups, and altered metabolites were obtained by ANOVA (fold change >2, P < 0.05) and identified with the online database Metlin and an in-house database.

Results

Metabolic profiling and multiple statistical analyses of the serum samples indicated significant differences between the NAFLD patients in the control and the 6-month vigorous exercise groups. Finally, 36 metabolites were identified between the control vs exercise groups. These metabolites were mainly associated with glycerophospholipid- and sphingolipid-related pathways.

Conclusion

Our study demonstrates that glycerophospholipid and sphingolipid alterations may contribute to the mechanism underlying the effect of exercise on NAFLD patients. A LC-MS-based metabolomics approach has a potential value for screening exercise-induced biomarkers.
AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center
Authors: Daly Adrian F , Cano David A , Venegas-Moreno Eva , Petrossians Patrick , Dios Elena , Castermans Emilie , Flores-Martínez Alvaro , Bours Vincent , Beckers Albert , Soto-Moreno Alfonso
Published: March 2019

Background

Pituitary adenomas have a high disease burden due to tumor growth/invasion and disordered hormonal secretion. Germline mutations in genes such as MEN1 and AIP are associated with early onset of aggressive pituitary adenomas that can be resistant to medical therapy.

Aims

We performed a retrospective screening study using published risk criteria to assess the frequency of AIP and MEN1 mutations in pituitary adenoma patients in a tertiary referral center.

Methods

Pituitary adenoma patients with pediatric/adolescent onset, macroadenomas occurring ≤30 years of age, familial isolated pituitary adenoma (FIPA) kindreds and acromegaly or prolactinoma cases that were uncontrolled by medical therapy were studied genetically. We also assessed whether immunohistochemical staining for AIP (AIP-IHC) in somatotropinomas was associated with somatostatin analogs (SSA) response.

Results

Fifty-five patients met the study criteria and underwent genetic screening for AIP/MEN1 mutations. No mutations were identified and large deletions/duplications were ruled out using MLPA. In a cohort of sporadic somatotropinomas, low AIP-IHC tumors were significantly larger (P = 0.002) and were more frequently sparsely granulated (P = 0.046) than high AIP-IHC tumors. No significant relationship between AIP-IHC and SSA responses was seen.

Conclusions

Germline mutations in AIP/MEN1 in pituitary adenoma patients are rare and the use of general risk criteria did not identify cases in a large tertiary-referral setting. In acromegaly, low AIP-IHC was related to larger tumor size and more frequent sparsely granulated subtype but no relationship with SSA responsiveness was seen. The genetics of pituitary adenomas remains largely unexplained and AIP screening criteria could be significantly refined to focus on large, aggressive tumors in young patients.
El último proyecto del GATEPAC. El Proyecto de Sixto Illescas para el concurso de ensanche de A Coruña en 1940
Authors: Díaz Gallego Francisco Dinís
Published: March 2019

En el presente artículo se analiza proyecto realizado por el arquitecto catalán, miembro del GATEPAC, Sixto Illescas para el Concurso de Proyectos de Ensanche de A Coruña, convocado en febrero de 1940 por el alcalde José Pérez Ardá a fin de satisfacer las necesidades de expansión de la ciudad y realizar dos proyectos clave en las primeras décadas del siglo XX: el Estadio Municipal de Riazor y el Parque Joaquín Costa en el monte Santa Margarita. Los equipos participantes serán fiel reflejo del estado del urbanismo de posguerra y del resultado del Concurso y la composición de su jurado saldrá el que será el primer Plan General de la ciudad, el Plan Cort de 1945. La obra del arquitecto catalán constituye el único proyecto conservado de dicho concurso, y se podría decir que se trata del último proyecto del GATEPAC.
Xentrificación e comunidade artística en Lisboa
Authors: Rodríguez González Miguel Anxo , Lestegás Iago
Published: March 2019

A cidade de Lisboa está a experimentar un profundo e rápido proceso de transformación urbana que comezou inmediatamente despois da crise financeira de 2008. Estimulada por un boom turístico e unha forte inxección de capital inmobiliario transnacional, a rehabilitación urbana avanza sobre centro histórico mellorando substancialmente o edificado pero provocando un ascenso imparable do prezo da vivenda que torna a cidade cada día máis inaccesible para os seus habitantes. Nesta investigación queremos achegarnos á comunidade artística para analizar como se está a ver afectada por este fenómeno e identificar as súas percepcións sobre o mesmo. A partir da análise do asentamento de diferentes colectivos independentes en varias zonas máis e menos centrais da capital portuguesa, suxerimos que a comunidade artística é primeiro vehículo e máis tarde vítima da xentrificación dos barrios onde se instala.
El maestro trasmerano Pedro de Morlote y la nueva cabecera de la catedral de Mondoñedo (1598-1603)
Authors: Gómez Darriba Javier
Published: March 2019

La catedral de Mondoñedo asistió a la mayor reforma arquitectónica de su historia entre 1598 y 1603. Entonces se demolió parte de su fábrica medieval para aumentar un tercio su tamaño gracias a la erección de una nueva cabecera, diseñada por el maestro de cantería trasmerano Pedro de Morlote. Analizaremos los motivos que llevaron a esta obra, su diseño, las fases de construcción, los modelos que se siguieron y el taller que la levantó.
Arquitectura, memoria y futuro. La mezquita-catedral de Córdoba
Authors: Lamprakos Michele
Published: March 2019

La Gran Mezquita de Córdoba es uno de los monumentos más importantes de la civilización islámica y un famoso sitio en la lista del Patrimonio Mundial. Sin embargo, durante casi ocho siglos ha servido como la catedral de la ciudad. En tanto que otras mezquitas en la península Ibérica fueron finalmente demolidas y reemplazadas por iglesias y catedrales en algún momento posterior a la conquista castellana, la Gran Mezquita de Córdoba sobrevivió. Fue modificada para el culto católico, en una adaptación que culminó con la inserción de un gran coro y un presbiterio (crucero) en el siglo XVI. Esto produjo una imagen curiosa y dual que ha confundido, perturbado y fascinado a los visitantes durante siglos: el edificio es una catedral, pero parece una mezquita. Tras la inserción del crucero, la estructura fue progresivamente "cristianizada", aunque solo para ser "re-islamizada" en los siglos XIX al XX. El intento actual de la Iglesia por afianzar su control, y la resistencia que esto ha provocado entre los activistas cívicos, es solo el último episodio de una extraordinaria historia de 800 años. La confrontación sobre la fábrica e interpretación del edificio testimonia la poderosa continuidad del legado arquitectónico islámico. Pero también es un barómetro del cambio de actitudes hacia el pasado islámico, y el significado de ese mismo pasado para la cultura y la sociedad españolas.
Delayed Surgical Management of Type A Intramural Hematoma Is Not Associated with Worse Outcomes Than Emergent Operation
Authors: Zhou Xun , Krishnan Aravind , Hsu Joshua , Burns Austin , Mandal Kaushik
Published: March 2019

Objectives: Management of acute aortic intramural hematomas (IMHs) involving the ascending aorta and root remains controversial. Some series have suggested that delaying operative intervention beyond the first 24-hours may be beneficial.
Methods: A retrospective single-institution analysis was performed to identify patients presenting with type A IMH. These patients were classified by whether they underwent surgery within 24 hours or delayed operative intervention. Patients with additional indications for emergent operation, such as acute aortic regurgitation or malperfusion syndromes, were excluded. Outcomes were assessed with logistic regression, and the Kaplan–Meier method was used to analyze long-term survival.
Results: Of the 129 patients with acute type A aortic pathology, 36 (27.9%) presented with isolated IMH. IMH patients were less likely to present with acute aortic regurgitation (8.6% versus 27.9%, P = .020) or limb ischemia (0% versus 12.6%, P = .027). Of the IMH patients without other emergent operative indications, 23 (67.6%) underwent surgery within 24 hours. Delayed operative repair was not associated with increased risk of mortality, stroke, or renal failure (all P >.05). Survival analysis showed no difference in survival at 1 year.
Conclusions: In well-selected patients, delayed operation for type An intramural hematoma is not associated with adverse outcomes.
Nucleic Acid Metabolism in Patients with Severe Burn Injury and the Possibility of Its Correction
Authors: Vereshchagin E. I. , Mitrofanov I. M. , Samatov I. Yu. , Strel'tsova E. I. , Veinberg A. L. , Potter E. A. , Bogachov S. S.
Published: March 2019

Purpose. To assess changes in nucleic acid (NA) metabolism in severe burn injury and to develop recommendations for correction of the alimentary status taking into account changes in the NA metabolism. Materials and methods. All patients (37 patients with II–III degree thermal burns and a burn area of more than 40%) were divided into 2 groups: Group I included survivors (23 patients), group II consisted of the deceased. The intensity of the NA metabolism was assessed based on the dynamics of the of uric acid (UA) and oligonucleotides serum concentrations. Results. In the acute period of burn injury, marked decrease in UA levels (less than 100 μmol/l), with gradual stabilization in survivors is typical. In addition, a 2–3-fold increase in the concentration of serum oligonucleotides compared to the normal limit is typical for survivors in the acute period, and these changes were significantly different from the group of deceased patients starting from day 5. Taking into account the data obtained, the level of serum UA can be recommended in clinical practice for the assessment of alimentary status in burn disease, as well as a criterion for f the prescription of glutamine administration in critically ill patients. In patients with burn disease a decrease in the UA level to less than 100 μmol/l was regarded as an absolute indication for the use of L-glutamine products. The use of glutamine in patients with significant decrease in UA levels was accompanied by a significant increase in the intensity of NA metabolism, which was demonstrated by both an increase in uric acid levels (by 85% by day 10 after the start of glutamine administration, P<0.01) and restoration of repair processes. Conclusion. Therefore, there was a marked alteration of NA metabolism in both groups of patients with severe burn injury. At the same time, surviving patients are characterized by rapid recovery of NA metabolism. Glutamine was employed as a pharmacological agent that effectively abrogates the depression of NA metabolism.
Influence of concomitant medication on plasma concentration of amiodarone in patients with atrial fibrillation - A pilot study
Authors: Neag Maria Adriana , Muntean Dana Maria , Nacu Alexandra , Catinean Adrian , Farcas Anca , Vesa Stefan , Bocsan Corina , Vlase Laurian , Buzoianu Anca Dana
Published: March 2019

Background. Although amiodarone is a drug with many side effects, it is one of the most commonly used drugs in the treatment and prophylaxis of supraventricular and ventricular arrhythmias.
Aim. The purpose of this pilot study was to evaluate plasma concentrations of amiodarone in patients with atrial fibrillation (AF) and to identify possible drug-drug interactions between amiodarone and concomitant medications.
Method. A prospective observational study was conducted in 27 consecutive patients treated with amiodarone from May to July 2017 in a Clinical University Hospital. The patients included met our inclusion criteria. HPLC-UV was the device used to determine the plasma concentration of amiodarone.
Results. Only 51.8% of the patients had amiodarone plasma concentration within therapeutic interval (500-2500 ng/ml). The drugs associated to amiodarone in the therapeutic plan were diuretics, beta blockers, statins, antiplatelets, fluoroquinolones, non-steroidal anti-inflammatory drugs. We observed a statistically significant difference between the plasmatic concentrations of amiodarone in patients treated with furosemide vs. patients concomitantly treated with other drugs. Interactions between other mentioned drugs and amiodarone were not registered. We can report an underuse of amiodarone for more than 50% of the patients. Also, we found a significant interaction between furosemide and amiodarone, most likely through the interaction with MDR.
Conclusion. Furosemide may influence the pharmacokinetics of P-gp-interfering drugs. However, the relevance of these findings needs to be confirmed and further research is needed to characterize the interaction between amiodarone and furosemide.
Reducing prejudice through biased group contact?
Authors: Dambrauskas Karolis
Published: March 2019

[full article and abstract in English]

Using the methods of critical discourse analysis, this article analyzes the TV program Mission: Vilnija as an example designed to fight stereotypes about Lithuanian national minorities. The article shows how instead of improving inter-group relations, the program helps to ensure the status quo of unequal intergroup relations between the Lithuanian majority and the country’s national minorities. The case analysis supports the argument that if the idea of parasocial contact and prejudice reduction is built upon non-reflected, biased premises, it will not eliminate these forms of prejudice but will only preserve and/or reinforce them.
Cardiovascularis betegségek megítélése a gépjárművezetői engedélyek kiadásának vagy meghosszabbításának szempontjából az európai uniós jogharmonizációt követően
Authors: Végh Ernő , Kiss Balázs , Dézsi Csaba András
Published: March 2019

Abstract:

The European Union (EU) law harmonization expects from each EU country to apply the same principles and same standards of the medical evaluation of driving licenses. All EU member states have to apply common evaluations of the driving licenses – based on the EU Regulation 2016/1006 – at the latest from January of this year. Hungary launched this new regulation on the 12th of January 2018. The most important source document of the current national regulation is the expert consensus document “New Standards for Driving and Cardiovascular Diseases” published in 2013. This is the professional evaulation of the cardiovascular diseases which can influence driving, and its importance is highlighted because even the Hungarian law listed this document as a resource. In this summary, in accordance with the current law, we provide a practical guide for the day-to-day work of assessing the permission of driving licence in connection with the different kinds of cardiovascular diseases. Orv Hetil. 2019; 160(10): 370–377.
ANALISIS KRITIS HUKUM TERHADAP KEDUDUKAN AHLI WARIS PENGGANTI DALAM HUKUM KELUARGA ISLAM DI INDONESIA
Authors: Aziz Aang Abdul
Published: March 2019

AbstractThe substitute heir (plaatsvervulling) is not explicitly mentioned in the Qur'an and has opened various interpretations in Islamic inheritance law. One of them is the opinion issued by M. Yahya Harahap that legitimate Indonesian Law perspective on substitute heir. The opinion stated that grandchildren can replace their parent’s position as an heir of their grandfather, if their parent deceased before the grandfather. This interpretation is different from inheritance law in other Islamic countries. This paper is aimed todiscuss the background and  istinbath al hukmi used by M. Yahya Harahap in describing substitute heirs. With critical study on various library materials and interview, it was found that M. Yahya Harahap’s reason to determine the substitute heirs was influenced by customary law, and apllied 'urf and istilah (Mashlah Mursalah) as istinbath hukmi.Key words: istinbath al hukmi, inheritance law, wasiat wajibah, substitute heirAbstrakTidak disebutkannya ahli waris pengganti dalam Al-Quran secara tersurat telah mem­buka berbagai penafsiran dalam hukum waris Islam. Salah satunya adalah pendapat yang dikeluarkan oleh M. Yahya Harahap. Pendapat tersebut menyatakan bahwa cucu dapat mengganti posisi keahliwarisan orang tuanya yang lebih dahulu meninggal dari kakek untuk berhak mendapatkan harta warisan orang tuanya. Hal tersebut berbeda dengan penafsiran hukum waris pada umumnya, yang salah satunya tertuang dalam ketentuan kewarisan di Mesir, tidak dengan memberikan hak waris namun berupa wasiat wajibah. Tulisan ini bertujuan untukmengetahui latar belakang pendapat dan istinbath al hukmi yang digunakan oleh M. Yahya Harahap dalam mene­tapkan ahli waris pengganti. Dengan metode studi kritik terhadap berbagai bahan pustaka, ditemukan bahwa alasan penetapan ahli waris pengganti M. Yahya Harahap didasarkan pada hukum adat khususnya daerah Tapanuli Selatan, Sumatra Utara, dan dasar hukum yang digunakan yaitu ‘Urf serta Istilah (Mashlah Mursalah) sebagai istinbath hukmi.Kata Kunci : istinbath al hukmi, hukum waris, wasiat wajibah, ahli waris pengganti
TUJUAN NEGARA DALAM ISLAM MENURUT YUSUF AL-QARADHAWI
Authors: Abdullah Sigit Ridwan
Published: March 2019

AbstractYusuf al-Qaradawi is one of the figures of so many scholars who contributed to the thinking of the Islamic state. His attention to politics and state is evidenced by the   presence of some of his works such as الإسلام في الدولة فقه من (Fiqh of State in Islamic Perspective),  الشرعية السياسة (Political Sharia), الإسلام مواجهة في العلماني التطرف (Extreme Secular Attitudes towards Islam), وهم لا حقيقة اللإسلامية اللأمة (The Political Unit of Ummah is a Reality). This research tried to review Yusuf al-Qaradawi's view on Islamic state, using descriptive analytical methods and literature review upon the above stated Yusuf al-Qaradawi's books or writings. The research result shows that Islamic state according to Yusuf al-Qaradawi is "a state based on faith and thought." He stated that there are four objectives of Islamic government. Firstly, Islamic Government does not aim to control the nation and its natural resources, but to preserve and protect the people. Secondly, fulfill the mandate from the owner. Thirdly, uphold justice for the human race. Fourthly, strengthen the religion in the earth as the most important goal by establishing faith, hudud and applying the law and its messages.Keywords: Islamic State, State aims, Yusuf al-QaradhawiAbstrakYusuf al-Qaradhawi merupakan salah satu tokoh dari begitu banyak tokoh pemikir yang turut memberikan kontribusi pemikiran tentang negara Islam. Perhatiannya terhadap politik dan kenegaraan terbukti dengan adanya beberapa karya beliau seperti bukuمن فقه الدولة في الإسلام (Fiqih Negara dalam Perspektif Islam), السياسة الشرعية  (Politik Syariah), التطرف العلماني في مواجهة الإسلام (Sikap Sekuler Ekstrim dalam Menghadapi Islam), اللأمة اللإسلامية حقيقة لا وهم (Kesatu­an Politik Ummat Islam adalah Suatu Kenyataan). Penelitian ini menganalisis pandangan Yusuf al-Qaradhawi terhadap negara Islam dengan menggunakan metode deskriptif analitis dalam bentuk library research, terhadap buku-buku atau tulisan lepas Yusuf al-Qaradhawi tersebut di atas. Negara Islam menurut Yusuf al-Qaradhawi adalah “negara yang berlandas­kan akidah dan pemikiran.” Ia menyatakan bahwa ada empat tujuan pemerintah­an Islam yaitu: Pertama, Pemerintahan Islam tidak bertujuan untuk menguasai lahir batin, tetapi untuk memelihara dan melindungi rakyat. Kedua, menunaikan amanat kepada pemiliknya. Ketiga, menegakan keadilan bagi ummat manusia. Keempat, mengo­koh­kan agama di muka bumi sebagai tujuan yang paling utama dengan menanam­­kan akidah, hudud dan mengaplikasikan hukum dan pesan-pesan­nya.Kata kunci: Negara Islam, tujuan negara, Yusuf al-Qaradhawi
Building a database for curriculum mapping and analytics
Authors: Kang Yew-Beng , D. Nadarajah Vishna Devi
Published: March 2019

This article was migrated. The article was marked as recommended. Curriculum mapping of an outcomes-based programme using a database was developed using a relational database structure, and it functions as a searchable database by the use of keywords. Factors such as the framework of the programme, the database entity relationship diagram (ERD), benchmarking, terminology and nomenclature, analytics and integration with the learning management system requires careful consideration before implementation. Built into the structure of the curriculum database are the analytics features which identifies the curricula data using defined keywords. This enables staff and students to search through any programme or subject of interest to track a subject or keyword to the point of delivery with the use of the analytics feature. This results in the curricula information being transparent for all stakeholders, ensuring curriculum mapping and blueprinting of assessments are readily available.This paper reports on the implementation of a university-wide curricula database which includes multiple undergraduate and postgraduate programmes, including chronological versions of a programme at an institution with diverse health professions programmes, including medicine, dentistry, pharmacy. Additionally, this paper outlines the steps to design the curricula database, the development of the framework of the database and the analytics, the challenges in implementation, the results that can be obtained from such a database and the lessons learnt.
Activity and the density of rheumatologists in Russian Federation, 2013-2017
Authors: Son I. M. , Ivanova M. A. , Sokolovskaya T. A. , Liutsko V. V. , Dezhurny L. I.
Published: March 2019

The incidence of noncommunicable diseases is one of the problems for the health of the population. In this regard, an adequate supply of rheumatologists and other specialists is necessary for timely providing medical care to the population.

Aim. To analyze the current state of the provision of rheumatologists and their activities in the Russian Federation.

Material and methods. Used data of Federal statistical observation over the period from 2013 to 2017, the paper used statistical, analytical, descriptive methods of statistics.

Results. This article presents an analysis of the data of official statistics on the rheumatologists’ density. The results indicate the stability of the situation in this specialty, although in general there was a decrease in the staffing of outpatient clinics.

Conclusion. Study showed a decrease in specialists staffing and stable situation on the density of outpatient departments of medical organizations.
First-in-Human Phase I Study of Merestinib, an Oral Multikinase Inhibitor, in Patients with Advanced Cancer
Authors: He Aiwu Ruth , Cohen Roger B. , Denlinger Crystal S. , Sama Ashwin , Birnbaum Ariel , Hwang Jimmy , Sato Takami , Lewis Nancy , Mynderse Michelle , Niland Michele , Giles Jennifer , Wallin Johan , Moser Brian , Zhang Wei , Walgren Richard , Plimack Elizabeth R.
Published: March 2019

Background

The purpose of this nonrandomized, open-label, phase I study (NCT01285037) was to evaluate the safety and tolerability of merestinib, an oral antiproliferative and antiangiogenic kinase inhibitor, and to determine a recommended phase II dose and schedule for patients with advanced cancer.

Materials and Methods

This was a multicenter, nonrandomized, open-label, phase I study of oral merestinib consisting of six parts: dose escalation (part A), followed by a four-cohort dose-confirmation study (part B) and subsequently a four-part dose expansion and combination safety testing of merestinib with standard doses of cetuximab (part C), cisplatin (part D), gemcitabine and cisplatin (part E), and ramucirumab (part F) in patients with specific types of advanced cancers. Safety, tolerability, antitumor activity, and pharmacokinetics were evaluated in all cohorts.

Results

The dose escalation, confirmation, and expansion results support the dosing of merestinib at 120 mg once daily, based on acceptable exposure and safety at this dose. One complete response was observed in a patient with cholangiocarcinoma, and three patients with cholangiocarcinoma achieved a partial response. Overall, 60 (32%) of the 186 patients enrolled in the study had a best response of stable disease.

Conclusion

This study demonstrates that merestinib has a tolerable safety profile and potential anticancer activity and warrants further clinical investigation.

Implications for Practice

Merestinib treatment in patients with advanced cancer demonstrated an acceptable safety profile and potential antitumor activity, supporting its future development in specific disease populations as a monotherapy and/or in combination with other therapies.
Hydraulic conductivity of reconstituted clays based on intrinsic compression
Authors: Zeng Ling-Ling , Cai Yuan-Qiang , Cui Yu-Jun , Hong Zhen-Shun
Published: March 2019

A series of one-dimensional incremental load consolidation–hydraulic conductivity tests was performed on reconstituted clays. Based on these tests, together with the test data compiled from the literature, the quantitative interrelation between the variation of hydraulic conductivity in the vertical direction with void ratio and the compression behaviour is established. It is found that the hydraulic conductivity in the vertical direction can be expressed as a function of void index, initial void ratio and void ratio at the liquid limit. The effects of initial void ratio and void index on hydraulic conductivity in the vertical direction for a given clay with a given void ratio at the liquid limit can be comprehensively attributed to the effect of void ratio on hydraulic conductivity in the vertical direction. These two findings introduce the point that the hydraulic conductivity in the vertical direction is a function of void ratio and void ratio at the liquid limit. Empirical equations are proposed to determine the hydraulic conductivity in the vertical direction using void ratio and void ratio at the liquid limit or using effective vertical stress, initial void ratio and void ratio at the liquid limit. These two empirical equations are correlated based on the concept of intrinsic compression.
Watching the bonding between steel rebar and concrete with in situ X-ray imaging
Authors: Bostel Rudney , Dos Santos Ana Carolina Parapinski , Lopes Joao Bernardino , Willrich Fabio Luiz , Hönnicke Marcelo Goncalves
Published: March 2019

Pull-out tests combined with an in situ radiographic movie are presented in order to investigate bond properties between steel rebar and concrete during tests on concrete reinforcement samples. Rebar relative displacement and other theoretically anticipated properties during the loading process, such as regions inside the concrete with maximum compression and longitudinal cracks, could be visualised and detected. Future studies on corrosion of reinforcement using such a combined technique are envisaged.
Exploring Relationship among Green Product Intention and its Determinants
Authors: Bhagat Rohit , Chauhan Vinay
Published: March 2019

In the recent years there has been a lot of growth in consumer intention towards purchasing green products. Environmental concern has been described as a vital force for achieving sustainable development. Evidences reveal
that increasing environmental concern has positively influenced the consumption pattern of green products. This has lead to the concept of sustainable consumption in the behaviour which in turn led to a greater faith in energy efficient products and
appliances for environmentally sustainable consumers. The last decade has witnessed an impressive increase in Environmental concern which has had a greater effect on consumer intention for the Green products. The increase of the environmental
knowledge has had a thoughtful effect on consumer behaviour, with the green product market expanding at a remarkable rate The present study shows that environment concern is evidently predicted from consumers’ purchasing patterns, with consumers
increasingly preferring to buy ‘green products. The study tries to develop relationship among environmental knowledge, normative beliefs and perceived consumer effectiveness, and their effect on intention towards sustainable green products.
Indonesian students’ perceptions of mnemonics strategies to recognize Japanese kanji characters
Authors: Rasiban Linna Meilia , Sudana Dadang , Sutedi Dedi
Published: March 2019

ABSTRACTThe purpose of this study is to explore university students’ perceptions of the effectiveness of recognizing Japanese Kanji characters by using mnemonic strategies and of understanding Kanji’s meanings. Fifty Indonesian university students majoring in Japanese Language Education participated in this study. Data were collected through an online questionnaire survey and an in-depth interview with Japanese as a foreign language (JFL) students. Drawing on the analysis of questionnaire and interview data, students reported that the use of mnemonic strategies successfully enhanced their comprehension of Japanese Kanji characters lexically and semantically. The ﬁndings also showed that the mnemonic strategy was so applicable that students could recognize Japanese Kanji characters. The use of technology also mediated the adoption of the mnemonic strategy. Thus, the implication of the study is that by using different mnemonic strategies along with the use of technology, Japanese teachers could teach Japanese Kanji characters to students whose writing systems background is other than Latin/Roman alphabet systems.
Towards multimodal interactions in the multilingual EFL classroom: Lessons from a COIL experience
Authors: Pouromid Sajjad
Published: March 2019

Internationalization of higher education has recently gained momentum, and many tertiary education institutions have felt it incumbent upon themselves to foster this trend. Due to lack of resources, student and faculty mobility has not always been a viable option, however. Thus, as an alternative to Internationalization Abroad, Internationalization at Home has gained popularity. Empowering learners by making them interculturally competent is one of the main concerns in this trend. Foreign language education within a curriculum that emphasizes intercultural interaction can, therefore, play significant roles in realizing the internationalization agenda. The present study was therefore designed to explore the nature of such intercultural interactions from a conversation analytic view. It builds upon data collected from audiovisual intercultural exchanges of 16 Japanese and 18 Taiwanese students engaged in a Collaborative Online International Learning (COIL) program between a Japanese university and a university from Taiwan. The data is used to shed light on the less explored potentials of COIL in bringing together EFL classes from across borders and giving learners the opportunity to engage in intercultural interactions in a virtual multilingual context. The conversation analysis of the video recorded interactions of the learners indicates how they use a variety of multimodal resources to maintain intersubjectivity with their peers from a different cultural background when they evaluate their English proficiency as inadequate. The results also suggest that multimodal and translingual practices frequently occur in classes where learners do not share an L1 and therefore have to be systematically attended to.
KAJIAN PEMBIAYAAN MURABAHAH TERHADAP PENDAPATAN OPERASIONAL. STUDI KASUS BANK BNI SYARIAH
Authors: Nurhayati Nurhayati
Published: March 2019

KAJIAN PEMBIAYAAN MURABAHAH TERHADAP PENDAPATAN OPERASIONAL. STUDI KASUS BANK BNI SYARIAH
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN AKUNTANSI DI SMA LABORATORIUM PERCONTOHAN BANDUNG
Authors: Anisa Muni
Published: March 2019

PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN AKUNTANSI DI SMA LABORATORIUM PERCONTOHAN BANDUNG
ANALISIS PENGGUNAAN ALAT EVALUASI PADA MATA PELAJARAN PRODUKTIF AKUNTANSI KELAS X AKUNTANSI DI SMK NEGERI 1 SURABAYA
Authors: Nurwinda Ragil
Published: March 2019

ANALISIS PENGGUNAAN ALAT EVALUASI PADA MATA PELAJARAN PRODUKTIF AKUNTANSI KELAS X AKUNTANSI DI SMK NEGERI 1 SURABAYA
PENGARUH MOTIVASI BERPRESTASI DAN KOMPETENSI TERHADAP KINERJA GURU
Authors: Nugraha Nugraha
Published: March 2019

Penelitian ini berlatar belakang munculnya fenomena yang menunjukkan bahwa sertifikasi guru yang bertujuan meningkatkan kompetensi sekaligus kesejahteraan guru ternyata tidak sesuai dengan yang diharapkan. Guru yang telah lolos sertifikasi ternyata tidak menunjukkan peningkatan kompetensi yang signifikan. Faktor yang mempengaruhi kinerja tersebut diantaranya motivasi berprestasi dan kompetensi. Penelitian ini menggunakan metode survey dengan pendekatan kuantitatif. Populasi berjumlah 225 orang dan sampel berjumlah 155 orang. Hasil dari penelitian ini adalah motivasi berprestasi guru (X1) berpengaruh secara langsung terhadap kompetensi guru (X2) sebesar 0,6630, motivasi berprestasi guru (X1) terhadap kinerja guru (Y) berpengaruh langsung sebesar 0,4020 dan pengaruh tidak langsungnya  yang melalui kompetensi guru (X2) sebesar 0,1833. Pengaruh dari kompetensi guru (X2) terhadap kinerja guru secara langsung sebesar 0,5672.
PENGARUH EFISIENSI MODAL KERJA TERHADAP PROFITABILITAS PADA PERUSAHAAN TEKSTIL DAN GARMEN
Authors: Novianty Dinni Endah
Published: March 2019

Penelitian ini bertujuan untuk mengetahui pengaruh efisiensi modal kerja terhadap profitabilitas pada Perusahaan Tekstil dan Garmen yang Terdaftar di Bursa Efek Indonesia periode 2011-2014, dimana efisiensi modal kerja diukur menggunakan Working Capital Turnover (WCT), dan profitabilitas diukur menggunakan Return on Investment (ROI). Metode penelitian yang digunakan adalah metode deskriptif dan verifikatif. Adapun teknik pengumpulan data yang digunakan adalah metode dokumentasi. Data berupa laporan keuangan dan laporan tahunan yang diperoleh dari situs resmi Bursa Efek Indonesia. Populasi dalam penelitian ini adalah 18 perusahaan tekstil dan garmen yang terdaftar di Bursa Efek Indonesia (BEI) periode 2011-2014. Teknik pengambilan sampel menggunakan purposive sampling, dengan seluruh anggota populasi dijadikan sampel. Pengolahan data dalam penelitian ini menggunakan perhitungan statistik regresi linier sederhana. Sebelum melakukan analisis regresi linier sederhana, dilakukan normalitas dan uji linieritas. Selanjutnya, dilakukan pengujian regresi menggunakan uji F, kemudian dilanjutkan dengan pengujian keberartian koefisien regresi dengan menggunakan uji t. Berdasarkan hasil pengolahan statistik diperoleh persamaan regresi WCT. Melalui pengujian hipotesis, persamaan regresi tersebut menunjukkan bahwa efisiensi modal kerja berpengaruh positif terhadap profitabilitas dengan koefisien sebesar . Artinya, apabila efisiensi modal kerja mengalami kenaikan sebanyak satu kali maka profitabilitas pun akan meningkat sebesar  kali.   Kata Kunci: Efisiensi Modal Kerja, Profitabilitas
PENGARUH PROFITABILITAS DAN SOLVABILITAS TERHADAP HARGA SAHAM PADA EMITEN SEKTOR PROPERRTY DAN REAL ESTATE DI BURSA EFEK INDONESIA
Authors: Faruk Umar
Published: March 2019

Penelitian ini bertujuan untuk mengetahui: (1) gambaran profitabilitas emiten sektor property dan real estate di BEI tahun 2010, (2) gambaran solvabilitas emiten sektor property dan real estate di BEI tahun 2010, (3) gambaran harga saham emiten sektor property dan real estate di BEI tahun 2011, (4) pengaruh profitabilitas  terhadap harga saham saham pada emiten sektor property dan real estate di BEI tahun 2011, (5) pengaruh solvabilitas terhadap harga saham pada emiten sektor property dan real estate di BEI tahun 2011 dan (6) pengaruh profitabilitas dan solvabilitas terhadap harga saham pada emiten sektor property dan real estate di BEI tahun 2011. Profitabilitas   diukur melalui Return on Assets (ROA), dan solvabilitas diukur menggunakan Debt to Equity Ratio (DER). Metode penelitian yang digunakan adalah  metode deskriptif verifikatif. Sampel penelitian ini adalah seluruh emiten property dan real estate yang terdaftar di BEI  serta aktif menerbitkan laporan keuangan selama tahun pengamatan, yaitu sebanyak 40 emiten. Pengumpulan data dilakukan dengan cara mengambil dokumentasi laporan keuangan dari BEI dan diolah menggunakan uji statistik regresi linier berganda. Berdasarkan hasil penelitian dapat diketahui: (1) secara umum profitabilitas   sektor property dan real estate memiliki nilai ROA yang rendah, oleh karena itu harus bisa lebih meningkatkan kinerja, sehingga memperoleh laba yang tinggi, (2) secara umum solvabilitas perusahaan sektor property dan real estate masih terdapat beberapa perusahaan yang memiliki hutang yang tinggi sehingga memiliki rata-rata yang tinggi,(3) secara umum harga saham sektor property dan real estate masih masih rendah karena masih terdapat perusahaan yang memiliki harga saham dibawah rata-rata sektoral, (4) profitabilitas berpengaruh positif terhadap harga saham pada sektor property dan real estate tahun 2011, (5) Solvabilitas tidak berpengaruh terhadapa harga saham pada sektor property dan real estate dan (6) profitabilitas dan solvabilitas berpengaruh terhadap harga saham pada emiten sektor property dan real estate. Kata Kunci: Sektor Property dan Real Estate, Profitabilitas (ROA), Solvabilitas (DER) dan Harga Saham.
PENGARUH PENGGUNAAN MODUL PADA PEMBELAJARAN MATERI PENCATATAN TRANSAKSI PERUSAHAAN MANUFAKTUR TERHADAP HASIL BELAJAR SISWA SMKN 1 SURABAYA
Authors: Rochmawati Rochmawati
Published: March 2019

Studi penelitian ini bertujuan untuk mengetahui pengaruh penggunaan modul pada pembelajaran materi pencatatan transaksi perusahaan manufaktur terhadap hasil belajar siswa SMKN 1 Surabaya. Jenis penelitian ini adalah penelitian kuantitatif. Populasi dalam penelitian ini adalah seluruh siswa kelas XII Akuntansi SMKN 1 Surabaya. Sampel dalam penelitian ini adalah kelas XII AK3 sebanyak 39 siswa sebagai kelas eksperimen dan kelas XII AK1 sebanyak 40 siswa sebagai kelas kontrol. Teknik pengumpulan data menggunakan tes dan angket pendapat siswa. Teknik analisis data menggunakan uji t test. Hasil analisis data dengan t-test menunjukkan bahwa nilai equal variances assumed dengan nilai T hitung sebesar 9,398 lebih besar daripada t-tabel yaitu  1.66488 dengan signifikansi 0,000≤0,005. Hal ini menunjukkan bahwa terdapat perbedaan hasil belajar antara siswa yang diberi perlakuan pemberian modul dengan siswa yang tidak diberi perlakuan pemberian modul materi pencatatan transaksi perusahaan manufaktur terhadap hasil belajar siswa SMKN 1 Surabaya. Berdasarkan hasil perbedaan tersebut maka dapat disimpulkan bahwa terdapat pengaruh penggunaan modul pada pembelajaran materi pencatatan transaksi perusahaan manufaktur terhadap hasil belajar siswa SMKN 1 Surabaya. Kata Kunci: Pembelajaran, Modul, Hasil Belajar