bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of 12-octadecenoic acid methyl ester, an active ingredientin Kansui, in inhibiting non-small cell lung carcinoma cells potential
Authors: Qu Zicheng
Published: August 2023

Lung cancer is widespread in China and has many new cases and deaths. There are about 450000 new cancer patientsin China every year. Non-small cell lung cancer (NSCLC) accounted for 80%. Previous studies have found that T33,a TCM formula, has the function of treating cancer by inducing autophagy of Colorectal cancer. Therefore, his studyaims to determine the ability of 12-octadecenoic acid methyl ester (an active ingredient in T33) to induce autophagyof A549 non-small cell lung cancer to expand the available treatment methods for lung cancer patients. This study willmeasure cell killing by MTT in vitro and tumor size reduction of A549 xenografts in vivo and measure autophagy byLC3-A/B western blot. The positive control is taxol, and negative control is PBS/DMSO. In this study, by observingthe size of cancer cell tissue and the number of LC3-A/B, we can determine whether 12-octadecenoic acid methyl estercan successfully induce autophagy of NSCLC and thus generate the potential for the treatment of NSCLC. The resultsof this study will provide some potential theoretical basis for the principle of traditional Chinese medicine in treatingcancer.
Down-regulating CD4+CD25+T Cells Could Benefit CHB Patient with Mildly Elevated Alanine Aminotransferase by Applying Chinese Traditional Medicine
Authors: Yu Jianing
Published: August 2023

The hepatitis B virus (HBV) causes hepatitis B, an acute liver illness that raises the risk of liver failure, liver cancer, and cirrhosis. Chronic refers to a condition that lasts longer than six months. Currently, treatment is more biased toward severe patients. However, the therapy for patients with elevated ALT is also necessary but needs to be addressed. This paper will explore how the Chinese Traditional Medicine Bushen formula could benefit CHB patients will elevate ALT by reducing the number of CD4+CD25+T Cells. This work will use Flourescence-Activated Cell Sorter (FACS) and real-time PCR to measure the percentage of T-reg cells in mice with elevated ALT levels after treatment with the Bushen formula. The effectiveness of the Bushen formula on CHB patients has been proved in this paper, which could help millions of patients to have a better life quality once the side effects and the dosage for each individual are explored further.
More Games, More Playtime
Authors: Zhou Haochen
Published: August 2023

The global electronic gaming market has grown significantly, with 3.198 billion players generating a revenue of $196.8 billion in 2022. Gaming companies must understand their users and keep them engaged to succeed in this market. This article examines whether Steam, one of the top gaming enterprises, truly understands its users. Using one year's worth of data from 12393 players who made 200,000 purchases and played games on Steam, we conducted a k-means clustering analysis to identify four distinct user categories. Based on our findings, we suggest personalized services that Steam can offer to improve user stickiness.
Translation Quality Assessment in Translation Teaching
Authors: Zhou Xiangyan , Cai Yaru
Published: August 2023

Translation quality assessment, an indispensable part of translation teaching, has drawn much attention in translationstudies. To get an overview of the topic, this study systematically reviews previous research on translation qualityassessment to summarize achievements and point out avenues for future research. Bibliometric analysis was used toanalyze relevant journal articles from the Web of Science, a publisher-independent global citation database. The resultsdemonstrated that existing studies mainly discussed translation quality assessment procedures, assessment methods, andassessment tools. The study can provide a reference for quality assessment in translation teaching and research.
Construction of enterprise financial accounting cloud platformbased on big data
Authors: Li Yuxia
Published: August 2023

In this paper, we delve into the construction of an enterprise financial accounting cloud platform utilizing thecapabilities of Big Data. As the era of Big Data and cloud computing advances, robust, intelligent, and efficientfinancial management becomes crucial. We initially address the limitations of traditional financial accounting systems,underlining the potential of Big Data and cloud technology in overcoming these challenges. The proposed cloud-basedplatform's architecture is explored, emphasizing its essential components: data acquisition, data processing, and dataanalysis modules. The importance of data security in the cloud environment is also discussed. Lastly, the paper providesa practical implementation strategy for this platform and examines the transformative impact it can have on enterprisefinancial management
Studying primary pair-rule gene eve in the early development of Drosophila by using Zelda as approach.
Authors: Liu Muen
Published: August 2023

This paper mainly studies the primary pair-rule gene Even-skipped to reveal its position in the early transcription network established in the Drosophila embryo and gain a deeper view of the network. We used the genome activator Zelda as an approach. We found Zelda’s role in regulating Eve by committing CHIP- seq towards RNA polymerase and Zelda protein in wt and Zld- embryo. With the PWM matrix, we know transcription factors that might bind to eve. By further researching its TFs, we find the relationship between timing and pattern of expression of these genes involved in the early transcriptional network, while Zld is still our approach. Also, by looking into the specific gene, we find the possible timing mechanism on Eve based on the accumulation of earlier transcribed transcription factors. The role of maternally loaded transcription factors in early development is once again shown by affecting the timing and patterning of primary patterning transcription factors.
Graded teaching Mode in English Teaching in Higher Vocational Colleges
Authors: Li Yuying , Jiang Caixia
Published: August 2023

This paper takes English teaching in higher vocational colleges as the research object and discusses the graded teaching model in-depth. Firstly, this paper summarizes the current situation of English teaching in higher vocational colleges and the theoretical basis of graded teaching. Then, it constructs a graded teaching model from student grading principles, teaching content design, and teaching method selection. Finally, it evaluates the practical teaching effect of this model through case analysis. It is found that the graded teaching model can effectively improve the quality of English teaching in higher vocational colleges and provide useful enlightenment for the reform of English education in higher vocational colleges.
2DG Affects Liver Cancer Cell Ferroptosis By Affecting
Authors: Yang Xiaoze
Published: August 2023

Cancer cells are characterized by high proliferation but at the expense of enhanced metabolic rates. If the activeoxygen content in the cell exceeds the average level, cancer cells activate antioxidant defenses against this increase.Ferroptosis occurs when glutathione levels are reduced due to a lack of cysteine in the cell. Ferroptosis is a new type ofasymptomatic apoptosis. We chose to investigate the sensitivity of cancer cells to the effect of 2DG on ferroptosis. Theseinclude some effects of 2DG on intracellular NADPH solubility and NADPH’s role in converting cystine to cysteine incancer cells. The effect of cysteine on glutathione, the inhibitory effect of glutathione on ROS in cancer cells, and theaccumulation of ROS can lead to ferroptosis in cancer cells.
Comparison between Vancomycin and Fidaxomicin in treatment ofCDI
Authors: Wang Yihong
Published: August 2023

Clostridium difficile infection (CDI) has become more and more prevalent worldwide, requiring more attention frompeople to treat this infection. In this work, the epidemiology of Clostridium difficile infection in the world and China isdemonstrated, which can contribute to a better understanding of the way of infection and patients’ conditions of CDI andlook for possible methods or policies to help prevent the spread of this disease. On the other hand, there is a growingdemand for more reliable and efficient antibiotic treatments for CDI, of which fidaxomicin and vancomycin are regardedas the most common. This work aims to compare the chemical structures, action mechanisms, and cost-effectiveness offidaxomicin and vancomycin to assist choices between two antibiotics for CDI patients and healthcare workers.
Review of the Current Research in Animal Individual Recognition
Authors: Lin Kailuo
Published: August 2023

With the development of biological identification for human beings, it also develops such as fingerprint, facial recognition, and iris identification. Scientists and zoologists must be more content with the cumbersome ways of identifying previously existing animals. Old methods such as ear cutting, chip implantation, and nose print recognition harm animals and humans. It has to catch the animals or needed professionals for individual identification (e.g, identify sharks by taking photos of their fins). Therefore, more and more scientists and engineers are trying to develop more efficient methods for individual animal identification. Of course, there are also many very constructive cases. Thus, this literature review will provide information about three regions of the latest recognition technology: radio-frequency identification (RFID), animal facial identification, and iris recognition.
Treatment with Increasing Amounts and for Various Durations of theAnticancer Agent Curcumol’s Effect on Stimulation of the Clearanceof HEP3b Xenograft Tumors and Decreasing of Jak3/Stat3 Signalingand Phosphorylation.
Authors: Yu Yankun
Published: August 2023

Human Hepatocellular Carcinoma is the second leading cause of cancer deaths, and it is undoubtedly easy to be infectedwith a destructive lifestyle. However, humans’ immune systems will be effective for cancer treatment if there is nosuppression of T cells brought by Jak3/Stat3 molecular activities. Fortunately, Curcumol has been proven effective forseveral cancer treatments and might also be helpful in HCC cancer treatment. This paper tends to prove that treatmentwith increasing amounts and for various durations of the anticancer agent Curcumol will stimulate the clearance ofHEP3b xenograft tumors and decrease Jak3/Stat3 signaling and phosphorylation in the in vivo conditions. STAT3phosphorylation and STAT3 mediated transcription will be measured by western blot analysis and STAT3 reporter assay.HEP3b killing will be measured by MTT assay. In the experiment, the Positive control is Taxol, and the negative controlis PBS/DMSO. Each experiment will be repeated five times with different concentrations and various treatment durationof Curcumol extractives, while all the experiments will be done in vivo. .
Assistant for math reviewing
Authors: Liu Qi
Published: August 2023

If students want to practice or review any knowledge, they may look for related exercises to improve their proficiency in the knowledge. But choosing exercises that fit students’ present proficiency by students themselves is difficult and wastes much time. The educational app: Assistant for math reviewing can find appropriate exercises automatically and dynamically for students to help them improve quickly and efficiently. This app gets students’ proficiency based on their performance in answering exercises and gives advice for students to review based on their proficiency. The author addresses the following questions: what kind of exercises or knowledge should students review? How often should students review? How Assistant for math reviewing helps students improve efficiently. This paper outlines how Assistant for math reviewing works, what benefits students can get from this app, why this app can offer benefits, and why this app is better than other tools for reviewing math.
Anchoring Effect and Salary Negotiation
Authors: Qin Jiayi
Published: August 2023

The anchoring effect is now frequently used in wage negotiations. This review article aims to discover the potential impact of the anchoring effect in wage negotiations. In the main body, we will analyze the potential impact of anchoring effects in three areas: anchoring strategies in wage negotiations, the impact of anchoring on wage differentials, and mitigating anchoring effects in wage negotiations. After the analysis, we will find that the anchoring effect stealthily has many potential impacts on wage negotiations.
On the logical rules of enterprise data validation --Observations based on one hundred and fifty adjudication documents
Authors: Zhou Wen Office of Cooperation and Exchange
Published: August 2023

Enterprises are essential participants in the data market. Properly defining the ownership of enterprise data can stimulate better the vitality of data and the enthusiasm of enterprise subjects. At present, the classification and grading of enterprise data are in a wide range of views, and it is difficult to unify the standard of confirmation of rights, so it is necessary to seek a proper rule of proof of ownership. Based on the observation of judicial practice, data rights should be confirmed in two steps: the first step is whether there are conditions for the confirmation of ownership, i.e., the necessity of data rights, including three specific aspects: the data has a particular scale and value; there is a data processing relationship between the user and the enterprise; and the purpose, scope, and way of using the data are legal. The second step is the specific steps to be taken to establish the right: in turn, five specific criteria are identified: whether the enterprise’s access to data is authorized, whether the data is desensitized, whether it is costly or intellectually demanding, whether the data can be recovered, and the type of data product.
The Molecular Pharmacology and Therapeutics of Angiogenesis
Authors: Wang Linxuan
Published: August 2023

Angiogenesis is the formation of new vasculature on top of the pre-existing ones, which is critical during the species’ lifespan. It is responsible for delivering oxygen and nutrients to metabolically active tissues, therefore playing an essentialrole in physiological conditions, such as wound healing and pathological circumstances, like malignancies. Althoughsharing similar characteristics, the blood vessels in pathological angiogenesis develop irregularly and disorganizedly.Therefore, the leakage of materials from blood vessels is familiar in abnormal angiogenesis, which may result inmuch higher interstitial pressure than internal pressure. Whether the angiogenesis is physiological or pathological,the proliferation of normal dormant endothelial cells is an essential requirement. Additionally, angiogenesis is alsoinitiated by vascular endothelial growth factor A (VEGF-A) interacting with the vascular endothelial growth factorreceptor 2 (VEGFR2) or the co-receptor neuropilin-1 (NRP-1). The Vegfa gene can be spliced in many ways, creatingnumerous VEGF-A isoforms, each with unique interactions with VEGFR2. Several drugs have been approved as thefirst- or second-line of angiogenesis, thereby preventing cancer progression. The widely used is monoclonal antibodies(bevacizumab) and receptor tyrosine kinase inhibitor (sorafenib and axitinib). However, they lack selectivity and, asa result, are less effective and have considerable adverse effects. As a natural drug, Paclitaxel has an anti-angiogeniceffect in addition to its chemotherapeutic effect. However, different doses of paclitaxel have different anti-angiogenicmechanisms and different effects on different species.
Whether Carotenoids and Quercetin Affect the Proliferation andExpression of PPARγ Protein in Leukemia K562 Cells
Authors: Liu Ziyan
Published: August 2023

Carotenoids are some of the most abundant pigments in nature, ranging from yellow to red. Carotenoids can divide intotwo categories: carotenoids composed of hydrocarbon elements and lutein-containing oxygen elements. They are lipidsoluble pigments, and some contain carbonyl or enol groups, which are water-soluble. Carotenoids absorb visible lightfrom 400 nm to 600 nm, while special ones such as octa-hydro lycopene and hexahydrolycopene only absorb ultravioletlight. Quercetin is a flavonoid compound widely found in fruits and vegetables. Its chemical structure phenolic hydroxylgroup is the basis of antioxidant action, which can be used for hydrogen to quench oxygen free radicals. It is oxidizedto form a highly stable catechol structure. It has a variety of biological activities and pharmacological effects, such asexpanding coronary blood vessels and inhibiting tumor cell proliferation. This paper shows that the K562 cell growthrate in carotenoids and quercetin treatment groups was slower than the control group.
Does Astragalus Membranaceus Polysaccharides in Astragalus Mongholicus as One of Six Herbs in Bushen Formula Can Be Effective to Decrease the Hepatitis B Viral Load and Alanine Aminotransferase of CHB Patients?
Authors: Yu Zhuocheng
Published: August 2023

Hepatitis B was the most widespread viral disease and had a very high infection in China during the last 40 years of the 20th to 21st century. The traditional Chinese medicine Bushen formula can treat hepatitis B by lower the mildly elevated alanine aminotransferase and HBV DNA levels for patients. Previous research has shown that the organic compound Astragalus polysaccharide can increase the percentage of CD4+ and CD8+ lymphocyte subsets and reduce hepatic damage caused by chronic hepatitis B. This study investigates APS in treating mice’s hepatic injury by building a CCl4- induced liver failure model and CD4+ CD8+ lymphocyte subsets in peripheral blood analysis models.
Inhibiting BMAA from Access to Decrease the Risk of Having Neurodegenerative Diseases
Authors: Xu Yangkun
Published: August 2023

Purpose: Neurodegenerative diseases are commonly seen in groups that have greater age. Although the exact pathway of Alzheimer’s is still unclear, the amino acid BMAA that Nostoc algae have fixed was predicted to inhibit PP2A proteins and cause Hyperphosphorylation on tau proteins and lead to tau protein tangle, which is the known agent that causes Alzheimer’s. So, the paper is dedicated to inhibiting BMAA from inhibiting PP2A kinases and seeing whether it can control the rate of neurodegenerative diseases’ appearance.
Studies of cosmic ray muons using CosmicWatch portable particledetectors
Authors: Zhang Zhe
Published: August 2023

Properties of muonMuons are unstable subatomic elementary particles thathave a half-life of 2.2 μs. A muon has a negative electriccharge of e and a mass of 105.65 MeV, approximately207 times as heavy as an electron. However, it is a lepton,which means it does not take part in strong nuclearinteraction and can penetrate through materials muchbetter than hadrons and mesons.
Overexpression of MCL-1 provides OCI-Ly1 with resistance toVenetocalx
Authors: Zhang Xinchi
Published: August 2023

Overexpression of MCL-1 is an antiapoptotic member of the BCL-2 family and has been seen in various human tumors,correlating with the patient’s poor prognosis. This study tested whether cancers overexpress MCL-1 to gain resistance tovenetoclax. The expression of MCL-1 protein was measured by Western blot. Cell viability after venetoclax and MCL-1inhibitor AZD5991 was added was measured by MTT. FP-based binding assays measured Venetoclax’s binding affinityfor MCL-1. The result of the study would give insights into venetoclax resistance and the overexpression of MCL-1 inNHL OCI-Ly1. Future studies should focus on new drugs that can circumvent this resistance if the hypothesis is correct.
Proposal of 14- Step Total Synthesis Route of Dihydrolucilactaene, a Potent Antimalarial Compound
Authors: Chen Jingcong , Du Sitong , He Guofeng , Tang Yutong
Published: August 2023

Malarial disease has been under heated discussion. The Osada group has extracted and purified pot antimalarial compounds, including dihydrolucilactaene and its derivatives. In this work, a 14-step total synthetic route of Dihydrolucilactaene, the compound with the highest pharmaceutical value among its derivatives, is designed and presented after considering and combining four partially feasible but hindered approaches. The complex molecule is first split into lactam-containing and long unsaturated fragments. The long unsaturated carbon chain can be effectively synthesized by two subsequent aldol condensations and the enabling Wittig reaction. Dicarbonyl synthesis and a basemediated intramolecular nucleophilic attack can synthesize the lactam fragment. The final connection between two fragments are conducted through an enolate attack of electrophilic nitrile followed by hydrolysis. Three protection groups, named trimethyl silyl, acetal, and N-Boc, facilitate the synthesis in the last step. This research successfully developed a 14-step efficient total synthetic route of dihydrolucilactaene with commercially available building blocks and catalysts. The proposed total synthesis route consists of developed and straightforward synthetic methodologies and therefore is expected to be efficient and have a high overall yield.
Domestic Solar Heating: Historical Development, System Description,Social Aspects, and Future Prospects
Authors: Yao Xun , Zheng Yuecen , Zhou Jiacheng
Published: August 2023

With the advancing technology, there are many well-developed domestic solar systems with two main categories: activeheating systems and passive heating systems. This paper focuses on a functional heating system which includes solarwater and air heating systems. The main physical principles are solar thermal energy and heat transfer, implementedon solar collectors and heat exchangers. As for the environmental aspect, domestic solar heating systems can reducegreenhouse emissions, alleviating global warming. Moreover, with the increasing demand for renewable energy due tothe rising awareness of environmental protection, the marketing size of solar energy has become larger. Solar heatingsystems have been a fast-growing technology in many countries over the last decade. Compared with other energy, theprice of solar energy is considered the cheapest, which can help consumers save around $5,000 with a payback time of 5years. Therefore, the solar heating market will expand in the future because of carbon emission reduction and increasingefficiency.
An Exploration of the Challenges Climate Change Has Brought to theChinese Economy and the Corresponding Strategies
Authors: Xu Kai
Published: August 2023

With the increasing use of fossil fuels, climate change in the 21st century is becoming the main development issue ofour era. The increasing severity of climate change affects daily life and brings great challenges to the global economy.The purpose of the paper is to explore the impact of global climate change on China’s economic development andanalyze China’s effective measures to deal with the challenges of climate change in the 21st century. Theoreticalinsights from East Asia Environment Monitor on Adapting to Climate Change (2007), which is the first regional reportin the “Environment Monitor” series, and Rosa (2003), who made a clear explanation of the relationship between worldenergy and climate change are synthesized in the context of global climate change. Both form a conceptual framework.In addition, we also review the research of Hugh Compston and Ian Bailey with their study focusing on climate policiesand anti-climate policies, and other professional experts in this field, such as B. Saranya and Mo Hong’e, who explorethe risk of climate change in the economy and discuss specific policies in China. It can be found that due to climatechange, various phenomena, including the rapid rise in global temperature, then changes in precipitation patterns andfrequent extreme weather, have occurred, affecting food and water supplies in developing countries and leading tosignificant losses to the production of China’s agriculture and animal husbandry. The study also finds that adaptation toclimate change is a complicated process that must integrate different measures, including efficient energy conversionand utilization, carbon sequestration, and alternative energy carrier like synthetic fuels. Overall, this study provideseffective measures for China’s response to the impact of global climate change on economic development.
SOCIAL-EMOTIONAL LEARNING IN ARTS EDUCATION
Authors: Wu Wenjun
Published: August 2023

The importance of arts education cannot be overstated, as it allows students to express themselves creatively and develop essential skills such as critical thinking and problem-solving. However, there is a growing concern that current arts education primarily focuses on knowledge acquisition and skill development while neglecting the emotional needs of students. In this paper, we explore the issue of utilitarianism in current art education and how current arts education neglects the emotional needs of students. Utilitarianism, which prioritizes the usefulness of education over its intrinsic value, often leads to a narrow focus on developing technical skills and knowledge at the expense of students’ emotional needs. We introduce the concept of socio-emotional learning and its impact on arts education. Socio-emotional learning is an educational method that promotes emotional growth, cooperative learning opportunities, and intuitive insights through arts integration. We argue that socio-emotional learning can help students better understand themselves and others and lead to more meaningful and fulfilling artistic experiences.
The Marketing Strategy and Story for CHANEL
Authors: Tao Yueyue
Published: August 2023

This article will focus on the main cultural strategies of luxury brands. For example, how luxury brands will use the marketing mix and how to improve the current ineffective strategy of luxury brands. This will provide current analysis and improvement methods for product, pricing, placement, and promotion strategies. The article will use Chanel as an example to discuss the point of view since Chanel is a world-renowned luxury brand. The paper will demonstrate how Chanel uses these marketing techniques to recruit target customers and also provides suggestions for Chanel’s marketing.
Restraining the non-small cell lung cancer (NSCLC) tumor by usingMART 10, a vitamin D analog and E-Cadherin
Authors: Zhan Fangyu
Published: August 2023

NSCLC is one of the most common types of cancer. Previous studies have reported that MART 10 has been affectinganaplastic thyroid cancer, indicating a decrease in the tumor after the injection of MART 10. Since previous studiesrarely investigate the effect of MART 10 within the NSCLC, this study investigates the effect of MART 10 in theNSCLC, both in vivo and in vitro methods. The study will use A549 cell lines, with negative control PBS and positivecontrol EGFR inhibitors or increasing MART 10—various methods, both in vitro, such as MTT, western blot, andwound healing assay. In vivo, such as A549 mice xenografts, the paper investigates whether or not MART 10 canrestrain the development of NSCLC tumors.
The Abortion Privilege: What Power Looks Like in the Aftermath of A Landmark Abortion Case Overturned
Authors: Yang Haoyun
Published: August 2023

On June 24, 2022, one of the most controversial Supreme Court cases, Roe v. Wade, landed in a ruling to overturn individual protections for abortion after five decades of legality. The decision, symbolizing not only reproductive freedom, reshaped America’s social, cultural, and economic landscapes. While scholars long studied variables influencing abortion attitudes in public polling data, few paid attention to rooting people’s attitudes in associated risks and imagined consequences of abortion overturned. The study used quantitative data from a demographic, attitudinal survey, and qualitative data from in-depth interviews to unpack the dense aftermath of the overturning of abortion rights on four levels: the individual, relational, societal, and cultural levels. Whereas gendered childcare, bodily autonomy, and the disenfranchisement of economic and symbolic power drove the discussions at the individual and relational levels, apprehension in the feminist agenda, political polarization, and socioeconomic status reflected public insecurities on the societal and cultural levels. This work conceptualized the profound social ramifications of abortion overturned by understanding people’s perceived social risks on different levels of impact, pointing out new productions of inequalities in this process.
Prediction of student online Learning performance based on Machinelearning
Authors: Chen Yu , Peng Jun
Published: August 2023

This essay uses machine learning methods to predict students’ online learning performance. The characteristicsof student’s characteristics, learning behavior characteristics, and environmental factors are extracted by featureengineering, and the random forest model is used for prediction. The experimental results show that the predictionaccuracy of the random forest model reaches 0.82, which provides an effective means for the prediction of onlinelearning performance.
An Analysis of the Influence of French Colonization on the VietnameseEducation System
Authors: Wang Ruoxuan
Published: August 2023

At the end of the 19th century, to consolidate their colonial domination, the French colonists adopt various means, tryingto disintegrate the Vietnamese traditional Confucianism value system and establish the French-Vietnamese educationsystem. Crude colonial methods exacerbated the loss of Vietnamese national culture and the fission of social classes,but objectively speaking, they also contributed to the establishment of modern education in Vietnam. This paper triesto present the evolution process of Vietnamese education under French colonization, and on this basis, to analyze theimpact and influence of the F
BAG3’s Role in Indicating the Recurrence of TNBC
Authors: Chen Tiffany
Published: August 2023

Triple-negative breast cancer (TNBC) cells tend to resist chemotherapy drugs, making it essential to find other therapiesto treat this aggressive cancer. The inhibition of BAG3 with YM-1 is an option because BAG3 is overexpressed in over50% of TNBC patients. BAG3 positively regulates the EGFR pathway and cell proliferation, which means inhibiting itcould reduce TNBC tumor size and lessen the recurrence of TNBC. This paper looks at xenografting BT-549 cell linesin mice and treating them with docetaxel, PBS, and YM-1 at various concentrations. Changes in the tumor are trackedusing the tumor volume and weight of the mice. The results of this work will provide a better understanding of howBAG3 inhibition impacts cell proliferation and whether it can be an indicator of TNBC recurrence. Studying YM-1gives patients more options and the chance to find the best treatment.
Literature Review: The Influence of the Family Environment on Moral and Cognitive Development
Authors: Wang Yanan
Published: August 2023

The article mainly discusses the importance of family environment factors for children’s moral cognition development. Secondly, it discusses the mutual influence between parents and children, thus changing the atmosphere of the family environment. It also discusses how positive and negative changes in the closed environment of the family during Covid-19 will affect the moral cognitive development of adolescents. Finally, the direction of future research is proposed. In future studies, the consistency or similarity of the parents’ basic data should be considered to ensure that the children in the study have similar family environments and reduce the factors that will affect the data and conclusions. In conclusion, this paper confirms that the family environment is the basis for influencing children’s future development. The influence between children and parents is interactive. In future research, additional longitudinal research, cross-cultural research, and research on the role of emotion in moral judgment are needed to further improve the family environment’s impact on children’s moral cognition development.
Ochratoxin A (OTA) Affect OATPs and PEPTs and Cause RenalDisease
Authors: Wang Letianchu
Published: August 2023

Ochratoxin A (OTA) is a mycotoxin related to the kidneys. There is a consensus that the primary route in which OTAis excreted into the urine is via tubular secretion, possibly through the organic anion transport system. There are somekinds of multipiece organic anion-transporting polypeptides (OATPs), ATP-binding cassettes (ABC) transporters, andtransporters such as organic anion transporters (OATs). These renal transporters are essential in exacerbating OTAinduced nephrotoxicity as OTA penetrates the cell membrane. This work concluded that the renal tubule’s reabsorptionand secretion of OTA might play an essential role in OTA accumulation and nephrotoxicity. Also, it tells us it is essentialto consider the impact of albumin binding on transport in vitro when considering the clearance of OTA in vivo.
An empirical study on the influencing factors of consumers' second- hand car purchase intention
Authors: Wang Liyao
Published: August 2023

Based on the theory of consumer behavior and the theory of purchase intention and combined with the actual situation of China’s second-hand car market, this paper designs a measurement scale, conducts an empirical survey with potential car buyers as research objects, and uses SPSS software to conduct factor analysis on the survey data. The main influencing factors of second-hand car consumers’ purchase intention are studied. This paper draws the following conclusions: Firstly, among the direct influences on purchase intention, perceived value has the most significant influence. It shows that perceived value is an essential antecedent of second-hand car consumers’ purchase intention, and high perceived value can improve the purchase intention of second-hand car consumers. Perceived benefits directly impact the purchase intention and indirectly affect the purchase intention of second-hand car consumers through perceived value. Secondly, the perceived risk of second-hand car consumers has a significant impact on their perceived value and purchase intention, which indicates that when considering the purchase of a second-hand car, there is an invisible mental risk in the mind of consumers, which will seriously inhibit the enthusiasm of second-hand car consumers to buy. Finally, the reference group also has a particular influence on the purchase intention. This indicates that when consumers consider buying used cars, they will not only evaluate the value of things in their minds but also be influenced by the outside world.
Analysis of Consumer Behavior and Discussion of Personalized Marketing Strategy in the Era of Big Data
Authors: Zhao Fengping
Published: August 2023

This paper analyzes consumer behavior in the era of big data and explores personalized marketing strategies. Companies can gain valuable insights to develop customized marketing strategies using data mining techniques to analyze consumer behavior. This paper discusses the challenges and opportunities of big data in consumer behavior analysis and presents several case studies to illustrate effective personalized marketing approaches. The findings suggest that utilizing big data can significantly enhance the effectiveness of marketing strategies, leading to increased customer satisfaction and loyalty.
The application of high performance in our lives
Authors: Ma Li
Published: August 2023

This paper provides an overview of high-performance concrete (HPC), including its definition, behavior, development,design criteria, innovative structural application examples, prospects, challenges, and limitations. HPC is a special typeof concrete with higher strength, durability, and other properties than conventional concrete. Several factors, such asshrinkage properties, thermal properties, flexibility, and durability, influence HPC behavior. Design criteria for HPCinclude High strength design, water-cement ratio, temperature resistance, and other design properties. Over the years,HPC has evolved to meet the growing demand for high-performance structures, such as using recycled aggregates inHPC, developing self-compacting concrete (SCC), and developing ultra-high performance concrete (UHPC). Innovativestructural applications of HPC include the application of HPC in precast components, high-rise building structures, etc.The future of HPC is promising as it is continuously developed and optimized for various applications. However, thereare still some challenges and limitations to overcome, such as high production costs, maintenance work requirements,difficulty mixing, and so on. This paper provides valuable insights for engineers, architects, and researchers interested indesigning and constructing HPC structures.
The formation of the international immigrantsociety in modern Singapore
Authors: Li Haitao
Published: August 2023

In exploring the formation of the international immigrant society in modern Singapore, we delve into the intertwiningfactors that have shaped its unique social structure. We begin by examining the historical context, tracing the waves ofmigration that have influenced the nation’s identity. We then consider the effects of Singapore’s immigration policiesand how they’ve opened avenues for diversity. Moving forward, we dissect the influences of multiculturalism, which arevisibly ingrained in everyday life in Singapore. Lastly, we examine the economic drivers that make the city-state attractiveto immigrants. Throughout our analysis, we highlight the key roles of the government’s promotion of multiculturalismand its strategy to attract talent, affirming these as major contributors to the richness of Singaporean society...
Identify Elements of the VTA Projecting RPE Circuit Neurons inMouse Mus musculus Prefrontal Cortex
Authors: Liu Bingzong
Published: August 2023

The Reward Prediction Error (RPE) model was presented decades ago but still has elements adding to the theory asthe mystery of neuron signaling pathways unravels. Following the projections of the dopaminergic neurons, the RPEcircuit originates from the ventral tegmental area (VTA), goes to the nucleus accumbens (NAc) reaches a higherorder processing center, which is the prefrontal cortex (PFC). Furthermore, downstream GABAergic neurons will beactivated according to the “error,” which indicates the value difference between the anticipated and actual rewards. Thisstudy aims to investigate the intermediate steps of the circuit, if any, and the role these intermediate neurons played instimulating the GABAergic neurons after the sensory inputs are integrated and processed at the PFC. Numerous studieshave investigated the function and mechanism of the VTA-NAc-PFC connections, whereas this experiment focuses onthe second half of the circuit. At least one, and possibly many, PFC residing, VTA projecting neurons with long axonscan be identified.
Exploring the Power of GKE Networking: An In-depth Analysis ofKubernetes Node and Pod Communication in Google Kubernetes
Authors: Ou Yining
Published: August 2023

This paper analyzes the communication between Kubernetes nodes and pods in Google Kubernetes Engine (GKE). Weexplore the structure and features of GKE networking, including communication between nodes, nodes, and pods, andpods themselves. We also consider the network security and performance aspects. In addition, we analyze commonnetworking issues such as latency, packet loss, and network failures and provide solutions. Through our experimentalresults, we demonstrate the effectiveness of our proposed solutions and offer insights for future research in this area.This paper provides valuable insights for developers and operators who use GKE and want to optimize their networkingconfiguration.
Can a SME Understand Its Sustainable Practices?– A Case Analysis from the Combined Perspective ofNudging Theory and Sustainable Business Practicesin A Small Retailing Business in Australia
Authors: Ma Yiming
Published: August 2023

Sustainable business practices have been under a long-lasting and fierce debate about whether a business shouldpursue SDGs or make money. Several efforts have been made to answer this question, and the Nudging Theory, a newdevelopment in behavioral economics, has been introduced. However, research seldom emphasizes how to assist SMEsto fully understand the nudges and their related effectiveness to achieve SDGs, nor does it address the moral dilemmaspotentially involved. To fill this gap, the paper, by combining two theoretical models, develops a new framework tohelp SMEs comprehend their sustainable nudges in a moral and cost-effective approach so that SMEs’ potential mightbe fully stretched out. Also, a real-world case will be related to the theoretical Framework to assist with understandingwhich SMEs should place their emphasis on, coupled with descriptive and predictive analysis. The Process and theOutcomes of sustainable nudges are summarised as two crucial elements contributing to the effectiveness of suchsustainable nudges.
The Inhibition of Human Epithelial Cells Proliferation by Oridoninthrough Interrupted Notch Signalling Pathway
Authors: Xu Mingze
Published: August 2023

Since the Notch signaling pathway plays a vital role in cell proliferation, oridonin restrains cancer cell growth bylimiting the Notch pathway. The study aims to investigate whether oridonin can kill normal epithelial cells similar tocancer cells in vitro. Also, the study aims to find whether the inhibition of Notch-1 by oridonin is on a transcriptionallevel. Methods: The study will use human epithelial cells (MCF10A) and breast cancer cells (MCF7). These two typesof cells will be treated with various concentrations of oridonin (0.01mM, 0.1mM, 1mM, and 10mM) for a differentamount of time (24h, 48h, 72h). The cell viability will be measured by WST-1 assay. Possible Results: There areeight possible results, three for the proliferation of epithelial cells and two for the transcriptional level of Notch-1 inepithelial cells. Normal epithelial cells experience a more significant loss of viable cells compared with cancer cells:(1) with decreased transcription and expression of Notch-1; (2) with decreased expression of Notch-1 but no decreasein transcription; (3) with a decrease in transcription but no decrease in expression of Notch-1 (4) with no decreasein expression and transcription of Notch-1. Normal epithelial cells experience a similar or less loss of viable cellscompared with cancer cells, (5) with decreased transcription and expression of Notch-1; (6) with decreased expressionof Notch-1 but no decrease in transcription; (7) with a decrease in transcription but no decrease in expression of Notch-1(8) with no decrease in expression and transcription of Notch-1. Conclusion: The loss of normal cells is considered atrade-off for the anti-tumor activity of oridonin. If little or no damage to non-tumorigenic epithelial cells is detected,then oridonin may be a good cure for breast cancer with fewer side effects. Also, by investigating whether the inhibitionof Notch-1 by oridonin is on a transcriptional level, we can gain more insights into the mechanism of inhibition.
The Detection of Inactivated p53 Protein by a Biosensor
Authors: Cao Yuyang , Wang Yinan
Published: August 2023

P53 is a gene that closely correlates with human tumors. In this paper, we explore how various biology techniquescan be applied to detect the malfunction of p53. Firstly, we insert the GFP gene, as correctly translated p53 proteinwill undergo fluorescence. Secondly, we apply artificial enzymes such as an antibody, and the structure of functionalp53 protein differs from those that are incorrectly translated. The enzyme can detect this as its active site matches thestructure of the functional p53 protein. Lastly, we aim to detect not the p53 protein but its side product. Caspase 3 is theone we will target to find. In this paper, we carefully compare and contrast these three methods, and the choice shouldalways be considere with different experimental conditions. The detection using GFP should be the best method amongthe rest, as it gives a visually accessible result, is also easy, and can produce the result very quickly.
Analysis and suggestion on Disney Company’s business strategy
Authors: Liu Jinyao
Published: August 2023

As a media and entertainment company that flourished for nearly 100 years, Disney has greatly enriched people’s lives. The development course of Disney has practical significance for many entertainment companies today. Through the discussion of the business strategy of Disney Company, this paper discusses some problems that may exist in the current development of Disney Company. It puts forward some relevant suggestions to solve these problems, hoping to provide help for the future development of Disney Company. The limitation of this paper is that the financial analysis of Disney Company is less.
Semiparametric estimation of factors that affect the stock return
Authors: Wang Xinhao , Wang Yubing
Published: August 2023

The stock market is full of dynamics and uncertainty, and much research has been done to study the factors that candrive the stock price to fluctuate. The previous study focused on firm-specific factors such as dividends, book value,earnings, etc. Moreover, numerous studies have proven that such firm-specific factors can influence the movement ofstock prices.In this paper, we not only want to study the firm-specific factors such as sales to earnings ratio and earnings book valueratios, market capitalization, etc., but also we want to study whether the beta value, as well as the sector categories, candetermine the movement of the share price to some extent. In this sense, we choose the stock price of Russell 2000 andthe associated factors to study the underlying empirical relationship between them. We want to give investors the bestchance to pick the right stock with growth potential. We want investors to use these methods we lay out to find theirstocks in the future. You can use these methods to sort out stocks by your requirement and pick—diversified sectors tohave a high growth risk-averse portfolio.We highlight safer stocks for investors looking for more steady stocks that don’t fluctuate as much as the market.You can again manipulate the data to find stocks that fit your individual investing requirement. Only some people canstomach a very volatile stock with potentially significant gains. Some would rather have safer options that aren’t asvolatile.
The Relationship between Antibiotics and Disulfiram-like Reaction
Authors: Yan Ruyu
Published: August 2023

Drinking without antibiotics has become the consensus of more and more people. On this phenomenon this paper will introduce the principle of this. The article will briefly introduce the structure of the medication principle and partial historical development. Partial historical development of two different kinds of mainstream antibiotics, cephalosporin and metronidazole. Understand these two mainstream antibiotics from scratch, and understand the principle of the reason why we cannot have them with alcohol fundamentally. Furthermore, the article will briefly analyze the principle and phenomenon of the same side reaction produced by two antibiotics with different structures, namely, a disulfiramlike reaction, to explain and show what will happen if people have these two kinds of antibiotics after drinking the alcohol. In this way, this work will popularize the hazards and precautions of drug use after drinking to more nonprofessionals