bluuebunny/crossref_metadata_2025 huggingface dataset:
Metales pesados en tejidos y céstodos intestinales del tiburón puntas negras, Carcharhinus limbatus (Müller y Henle, 1839) del arrecife Santiaguillo, PNSAV, Veracruz, México
Authors: Montoya-Mendoza Jesús , Lara Esparza Karina Elizabeth , Castañeda-Chávez María del Refugio , Salgado-Maldonado Guillermo , Lango Reynoso Fabiola
Published: January 2024

Se analizó la concentración de cadmio (Cd), plomo (Pb) y cobre (Cu) en tejidos (músculo, hígado y gónada) y céstodos parásitos intestinales de especímenes de Carcharhinus limbatus, capturados de febrero a junio de 2019 en el arrecife Santiaguillo del Parque Nacional Sistema Arrecifal Veracruzano, Veracruz, México. Los metales pesados fueron cuantificados mediante el espectrofotómetro de absorción atómica. Los resultados de la concentración media de los contaminantes fueron: Pb, 0.02 a 0.06 (0.047±0.013) mg kg-1; Cd, 0.042 a 0.05 a (0.045±0.002) mg kg-1; y Cu, 0.01 a 0.06 (0.025±0.013) mg kg-1. Para los céstodos la concentración de los tres metales fue menor a 0.0028 mg kg-1. Todos los registros no excedieron los límites establecidos en la Norma Mexicana (NOM-242-SSA1-2009) La concentración de los metales pesados en los diferentes tejidos del tiburón no representan un riesgo para la salud por el consumo de C. limbatus.
study on factors influencing the performance of CMFs on measurement of high viscosity flows
Authors: Gace Dalson Athanase , Cheong Khoo Boo , Rongmo Luo
Published: January 2024

A Coriolis Mass Flowmeters (CMFs), outperform other flow measurement systems owing to their perceived high accuracy and good repeatability. That has attracted its use in different fields including the bunkering industry. Bunkering operations entail high viscosity flows that may limit the applicability of high accuracy CMFs.   Furthermore, their performance for measurement of single-phase high viscosity flow remains less explored and the mechanisms responsible for possible additional measurement error due to high viscosity fluid are not thoroughly studied. This study characterizes the performance of CMFs on the measurement of high viscosity fluid via CFD simulations. It is observed that the error of CMFs on measurement of high viscosity is deemed relatively large at low mass flow rates and which monotonically increases as the viscosity increases. The sudden pressure increase and secondary flow in the vicinity of the flow sensors’ locations are the key factors influencing the measurement discrepancy. It is worthy to note that this study is highly significant to the bunkering industry as it can serve as a baseline for further experimental works on the measurement of bunker fuel oils.
Novel Frequency Dependent OFET Attenuator Using ClInPc with Al2O3 Embedded Nanoparticles in Nylon 11 for Flexible Electronics
Authors: Hamui Leon , Sánchez-Vergara María Elena , Ferrer-Garcia Ignacio
Published: January 2024

The Organic field-effect transistors (OFETs) have been largely investigated due to their low-cost manufacturing, flexibility, and lightweight, as well as their optical and electrical characteristics. That allow its application in sensors, amplifiers, attenuators signal filtering, and high-frequency response devices, like biosensing, wearable electronics, optoelectronics, telecommunications, and other potential applications. Throughout this investigation, a ClInPc flexible OFET with Al2O3 embedded particles in nylon 11, was manufactured and characterized to evaluate the optoelectronic and morphological properties. For the manufacturing, a high-vacuum thermal evaporation deposition technique was used, and UV-vis spectroscopy analysis and scanning electron microscopy were conducted to evaluate the optoelectronic and morphological properties. Also, a study regarding the electrical characteristics for different time-dependent wavefunction input signals, changing the input voltage and frequency, has been conducted. The latter was driven to determine the time-response characteristics, gains, phase shift and to determine whether the device function as an attenuator or an amplifier with the selected configuration. The device has been modelled to obtain the OFET operation parameters. A resulting capacitance of 567 pF was calculated. Uniform and continuous films where obtained, which guarantees an efficient charge transport. For all signals the output voltage is lower than that of the input voltage. Also, for the higher frequency the output voltage is decreased compared to lower frequencies. Gains decreasing variation of up to 0.05 indicate the operating application as an attenuator. Phase variation of up to 100 °, resulted while varying the input frequency. The model resulted on a gate capacitance value between 500 and 1180 pF, and gate-drain capacitance value between 50 and 500 pF. All of this could give evidence that state of the art ClInPc flexible OFET device with Al2O3 embedded nanoparticles in nylon 11 could be used toward current high-performance frequency-dependent flexible applications.
ANÁLISE DA ADESÃO DOS ESTADOS BRASILEIROS AO PROGRAMA SAÚDE NA ESCOLA
Authors: Araújo Diogo Alves de , Martins Victor da Mota , Moimaz Suzely Adas Saliba , Saliba Tania Adas , Teixeira Symone Cristina , Barbieri Ana Amélia
Published: January 2024

The School Health Program (PSE) is a Primary Health Care (PHC) program formulated in an intersectoral way, articulating PHC professionals and schools to develop actions aimed at Brazilian schoolchildren. To adhere to the PSE, it is necessary to link PHC health teams with Oral Health teams and the Term of Commitment validated by health and education managers. This study aimed to verify the adherence of Brazilian states to the PSE as a strategic tool for integrating health and education for the development of citizenship and the qualification of Brazilian public policies. Research was carried out through a descriptive analysis of data contained in public databases of the Primary Care Health Information System (SISAPS) and the Brazilian Institute of Geography and Statistics (IBGE). It was observed that for the 2021-2022 Cycle, Piauí showed the highest percentage of adherence considering the number of municipalities, Minas Gerais showed more students benefiting considering absolute numbers and São Paulo is the state with the highest number of students enrolled in elementary education and the number of students benefiting. The PSE showed adherence above 80% in all Brazilian states, presenting itself as a strategic tool for integrating health and education for the development of citizenship and the qualification of Brazilian public policies.
Evaluation of OSB panels using residual wood with low contents of castor oil polyurethane resin
Authors: Barbirato Guilherme , Lopes Junior Wanley , Martins Romulo , Inácio de Campos Cristiane , Fiorelli Juliano
Published: January 2024

The use of residues from human activities has been currently gaining ground in the national and international markets, aiming toward the production of more sustainable materials that are less aggressive to the environment. Reusing and adding value to new products has also become an important factor in reducing production costs and the best alternative for this is process optimization. The choice for residual balsa wood was due to its rapid growth and low density, as well as for its ease of engineering and determining the ideal amount of resin for different types of panels. This study aims to investigate the influence of the content variation of castor oil-based polyurethane resin on the physical and mechanical properties of OSB board particles made from residual balsa wood in reforestation areas. The panels were produced with 8, 10, and 12 % commercial castor oil-based polyurethane resin and 9 mm long particles; their physical and mechanical characterizations followed international normative recommendations. The results indicated that the panels with resin contents higher than 10 % reached the minimum regulatory requirements for type 2 OSB panels, suitable for structural application. On the other hand, the panels produced with 8 % resin reached the minimum requirements for type 1 OSB panels, suitable for non-structural use by the furniture industry, such as linings and partitions. Therefore, our study concludes that the variation of resin contents for OSB panels of residual balsa wood allowed us to achieve optimal levels for the use of castor oil-based polyurethane resin, reaching minimum values recommended by regulations for OSB panels type 1 and 2 and a great possibility of application of this product for engineered materials.
The First Century of Hungarian Khitanology
Authors: Apatóczky Ákos , Szilágyi Zsolt
Published: January 2024

Hungarian scholarship has traditionally shown a deep interest in East Asian philology, and as a result has achieved several significant results in this field. Ever since the first written records of the Khitan (formerly also known as "kitaj" in Hungarian literature) were discovered at the beginning of the 20th century, Hungarian philologists have paid particular attention to these discoveries. The first scientific article on the subject in Hungarian was a 1927 study by Lajos (Louis) Ligeti. In this paper, we would like to give an overview of almost a century of research on the Khitans in Hungary.
Connected but Dispersed: Navigating Postmodernity in the Belt and Road Spaces
Authors: Nymdorj Manlai
Published: January 2024

“Postmodernity” or the “postmodern condition” is described as a cultural condition when capitalism penetrates further into the cultural world. Previously outside of global capitalism, Mongolia as one of the third wave of democracies after the fall of the Soviet bloc, is now slowly entering this state of postmodernity with increased exposure and connectivity with the global capitalist system. As postmodernity in effect, societies where cultural life was previously free of capitalist incorporation now left to navigate the world of competing ideas and narratives at increased speed, saturated by information through media presentations and hyperbole. The Belt and Road Initiative (BRI) is the most recent all-round project to add to an already saturated condition with its stream of information. As the BRI seeks to increase regional connectivity with China and subsequently with the rest of the world, further strengthening the global capitalist system, it welcomes another channel of various other forces further saturating and exhausting the postmodern condition. Often framed as an anti-exploitative alternative to globalization, the BRI brings competing narratives, ideas and cultural frameworks, fragmenting rather than binding together various other existing bubbles and dispersing them like atoms. Communities and localities located in the BRI sphere, though physically connected, now must navigate a very chaotic flow of information directed at them.
Geodorum laxiflorum (Orchidaceae) relectotypified with a new synonym
Authors: Mondal Swarnendu , Chakraborty Kasturi , Chakraborty Sayak , Sarkar Shuvadip , Sardar Sudipta , Bhattacharjee Avishek
Published: January 2024

Geodorum laxiflorum Griff. (Orchidaceae) is relectotypified here by
superseding Bhatt & al. (2015) and by designating a CAL-specimen as
lectotype of G. laxiflorum, as the lectotype designated by Bhatt & al.
(2015) for the name is found erroneous. Morphological variations along
with an overlooked character of the labellum of this Indian endemic and
vulnerable species of orchid are presented based on study of
livespecimens collected in the wild for the first time from two Indian
states. Further, the name Eulophia diffusiflora M.W. Chase, Kumar &
Schuit. is synonymised under G. laxiflorum until Eulophia R. Br. is
conserved against Geodorum Andrews.
Fritillaria shehbazii and F. selenica (Liliaceae), two new species from Iran
Authors: Advay Mahfooz , Tekşen Mehtap
Published: January 2024

Two new species from Iran was described in this study. Fritillaria
shehbazii from Western Azerbaijan province in northwest Iran and F.
selenica from Kurdistan province in western Iran. F. shehbazii is
similar to F. chlororhabdota, F. pinardii, F. kordestanica and F.
assyriaca in the F. caucasica group in general facies but differs mainly
by the color and size of its lowest leaves, shape and colour of perianth
segments. F. selenica is similar to F. avromanica and F. assyriaca in
general facies but differs mainly by narrower leaves and color of
perianth segments. Detailed taxonomic descriptions, diagnostic
characteristics, illustrations, original photographs, geographical
distributions, habitat, phenology and ecology, etymology, conservation
status, and identification key of the new and the related species are
presented in this study.
A new species of Onosma L. (subsect: Asterotricha, Boraginaceae) from western Iran
Authors: Advay Mahfooz , Attar Farideh , Saman Ahmad
Published: January 2024

Onosma safaie-fari (in subsect. Asterotricha) is described and
introduced as new species from Kurdistan province. O. safaie-fari
morphological similar to O. qandilica, however, it is seperated by
sterile shoot and cauline leaves shape; fruiting calyx length, calyx
lobes shape and width, corolla length, corolla color and anthers length.
Also Onosma safaie-fari closed to O. bisotunensis but it is
differentiated by sterile shoot and cauline leaves shape, lower bract
shape and length; length of fruiting calyx; corolla color and length;
free part of filaments length, position of filaments arising from
corolla and anthers length.
Development of premature children and the influence of sociodemographic factors on them: A cross-sectional study
Authors: Cavaggioni Ana Paula Magosso , Benincasa Maria
Published: January 2024

The objective of this study is to describe and correlate the development
areas of premature children and to verify the influence of
sociodemographic factors. This is a cross-sectional study with a
quantitative approach, conducted with 79 premature children aged from 15
days to 42 months old. The sociodemographic questionnaire and the Bayley
III Scale were used. The participants’ performance fell within the
expected parameters in the weighted and composite score and percentile
in all the domains evaluated. However, nearly 39% did not achieve full
acquisition in sensory processing and 50.6% presented at least one
statistically significant discrepancy when comparing two development
areas. The analysis performed and the set of results obtained were
considered relevant for constituting a risk indicator for childhood
development that can go unnoticed in healthy preterm infants, hindering
early intervention and leaving them vulnerable to difficulties
throughout life.
A Pan-cancer Analysis of Kelch Like Family Member 38 (KLHL38) Alterations in Human Cancers
Authors: Hai Linyue , Liu Yuetong , Meng Shuai , Zhao Jingjing , Liu Bowen , Huang Zhidong , Cao Xuchen , Liu Hong , Xiao Chunhua
Published: January 2024

Background: Growing evidence suggests that the KLHL family may be
involved in the occurrence and development of cancer. KLHL38, a member
of the KLHL protein family, contains BTB/POZ, BACK domains, and five to
six Kelch motifs. However, no pan-cancer analyses have been conducted on
KLHL38. In this study, we aimed to explore the potential biological
functions of KLHL38 that may provide potential tumor-related therapeutic
targets. Methods: The potential roles of KLHL38 in different tumor types
were explored based on The Cancer Genome Atlas (TCGA), Genotype-tissue
expression (GTEx), Tumor Immune Estimation Resource (TIMER), and Gene
Set Enrichment Analysis (GSEA) datasets. Several factors related to
KLHL38 were analyzed, including expression differences, survival,
pathological stage, DNA methylation, tumor mutation burden (TMB), tumor
microenvironment (TME), stemness score, and immune cell infiltration.
Results: There were significant differences in KLHL38 expression among
different cancer types and between cancer tissue and normal tissue,
which was closely correlated with survival prognosis. Furthermore,
KLHL38 expression was found to be correlated with DNA methylation, tumor
mutations, and stemness scores in major cancer types, suggesting its
involvement in cancer development. To some extent, KLHL38 expression
levels were significantly correlated with immune cell infiltration,
immune checkpoint genes, and immune regulatory genes. These results
indicated that KLHL38 can be used as a tumor prognostic indicator.
Conclusion: In our study, we analyzed the role of KLHL38 role in tumor
development and immunotherapy, which may provide a potential new target
for tumor treatment.
Relations between parenting stress, effortful control, and diurnal cortisol levels in toddlerhood
Authors: Wesarg Christiane , Akker Alithe van den , Oei Nicole , Creasey Nicole , Hoeve Machteld , Huijzer-Engbrenghof Marijke , Lalihatu Esmee , Spencer Hannah , Wiers Reinout , Overbeek Geertjan
Published: January 2024

High levels of effortful control have been shown to protect children
from negative health outcomes following early adversity. In this study,
we tested whether effortful control already moderates the effects of
parenting stress on children’s cortisol levels in toddlerhood. In 31
families, parental reports of parenting stress and toddlers’ effortful
control were obtained via questionnaires, and toddlers’ salivary
cortisol levels were assessed twice in the morning and once in the
evening. Contrary to expectations, parenting stress was not related to
toddlers’ cortisol levels, and effortful control did not moderate these
non-significant associations. Higher levels of parenting stress were
related to lower levels of toddler’s effortful control (r = -.43, p
=.016). Future work may examine at what age effortful control starts to
influence an individual’s psychobiological adaptation in the context of
(parenting) stress, which may inform prevention and intervention
approaches.
Impact and effectiveness of Pfizer BioNTech (BNT162b2) COVID-19 vaccine among adolescents (age 12yr to 15yrs), against SARS-COV-2 infection following a nationwide vaccination campaign: An observational study in Qatar.
Authors: Azeez Maktoum Abdul , Hussain Mir Saad , Veettil Shajitha Thekke , Mesallam Maha Saif Al , Muhammed Aysha Chalappurath , Abdulmajeed Jazeel , Krishnan Jeyaram Illiayaraja
Published: January 2024

Background: Following the worldwide mass vaccination to prevent
and protect the child population from the deadly virus, on 17th May
2021, the Primary Health Care Corporation (PHCC), Qatar launched the
BNT162b2 COVID-19 vaccine campaign among adolescents i.e., 12 to 15
years of age across region through all 27 health centers. We estimated
the safety and protective efficacy of the BNT162b2 COVID-19 vaccine
among the vaccinated and non-vaccinated adolescent population in Qatar.
Methods: A quantitative retrospective observational study
assessed the medical records of SARS-COV-2 positive adolescents (12-15
years) of all 27 Primary Healthcare Centres of PHCC. All data were
obtained during the second wave of the SARS-COV-2 pandemic from 17
June 2021 to 17 December 2021.
Results: The study data involved 1956 SARS-CoV-2 infection
(RTPCR positive) cases. Out of 1956 children, 20.55% were vaccinated
(n=402) and 79.45% were non-vaccinated (n=1554). The mean age for the
vaccinated group was 13.89 ± 0.93 and non-vaccinated group was 12.99 ±
0.93. The number of vaccinated participants 20.55% (n=402) of the total
sample size who contracted SARS-CoV-2 infections was significantly
lesser compared to the non-vaccinated population 79.45% (n=1554).
Incidence of the SARS-COV-2 infection was found to be statistically
significant among the vaccinated group who received 2 doses of
Pfizer-BioNTech vaccine (p-value<0.001) rendering the vaccine
effectiveness against prevention of the SARS-CoV-2 infections.
Conclusion: In summary, our findings indicate that protection
of Pfizer BioNTech (BNT162b2) COVID-19 vaccine against SARS-CoV-2
infections is satisfactory as only one-fifth of the total study
population contracted SARS-CoV-2 infections after the double dose
regimen. Our findings support the importance of maximizing vaccination
coverage for considering booster doses for adolescents to enhance
protection. Further studies will be needed to assess the duration of
protection and immune-prophylactic response and the need for booster
doses.
A Transformative Shift Towards Blockchain-based IoT Environments: Consensus, Smart Contracts, and Future Directions
Authors: Trivedi Chandan , Rao Udai , Parmar Keyur , Bhattacharya Pronaya , Tanwar Sudeep
Published: January 2024

Recently, blockchain-based IoT solutions have been proposed that address
trust limitation by maintaining data consistency, immutability, and
chronology in IoT environments. However, IoT ecosystems are
resource-constrained and have low bandwidth and finite computing power
of sensor nodes. Thus, the inclusion of blockchain requires an effective
policy design regarding consensus and smart contract environments in
heterogeneous IoT applications. Recent studies have presented blockchain
as a potential solution in IoT, but an effective view of consensus and
smart contract design to meet the end application requirements is an
open problem. Motivated by the same, the survey presents the integration
of suitable low-powered consensus protocols and smart contract design to
assess and validate the blockchain-IoT ecosystems. We discuss the key
blockchain concepts and present the scalability and performance issues
of consensus protocols to support IoT. Further, we discuss smart
contract vulnerabilities and blockchain attacks. Open issues and future
directions are presented, supported through a case study of low-powered
consensus protocol design in the blockchain- IoT ecosystem. The survey
intends to drive novel solutions for future consensus and safe, smart
contract designs to support applicative IoT ecosyst
Immunogenicity and safety of the BBIBP-CorV vaccine in patients with autoimmune inflammatory rheumatic diseases and immunosuppressive therapy in a monocentric cohort
Authors: Zamani Batool , Hasan-Abad Amin Moradi , Piroozmand Ahmad , Dehghani Mahsa , Arfaatabar Maryam , Motedayyen Hossein
Published: January 2024

Introduction: Vaccination plays a fundamental role in mastering the
COVID-19 pandemic and protecting vulnerable groups. Persons with
autoimmune inflammatory rheumatic diseases (AIIRD), on immunosuppressive
therapies, are prioritized for vaccination. However, data concerning
immunogenicity and safety of the BBIBP-CorV vaccine in immunosuppressed
patients are not found. This study presents data on the efficacy and
safety of the BBIBP-CorV vaccine in immunosuppressed patients compared
to healthy controls. Methods: Study population consisted of 100 healthy
controls and 100 patients with AIIRD. Vaccination was performed
according to national guidelines with the BBIBP-CorV vaccine. SARS-CoV2
neutralizing antibody titers were quantified by ELISA before initial
vaccination and 1–3 months after secondary vaccination. Adverse events
were assessed before study initiation and 7 days after the second dose.
Disease activity was studied before entering the study and 3-8 weeks
after the second dose. Results: Vaccination-induced positive immunogenic
response rates and SARS-CoV2 neutralizing antibody titers were
significantly lower in the AIIRD patients than healthy subjects
(P<0.05). There are significant differences in neutralizing
antibody titers among patients suffering from RA, SLE, SSc, and AS
(P<0.01-0.05). The rates of seropositive vaccine responses
were similarly distributed across all diseases. Healthy and AIIRD
individuals had a similar profile in adverse events. No significant
difference was observed in SARSCoV2 antibody titers between subjects
suffering from side effects and those who did not have. SARS-CoV2
neutralizing antibody levels were significantly higher in
SARS-CoV2-infected persons than noninfected subjects
(P<0.01-0.05). Seropositive subjects had a significant
increase in the percentage of vaccine-related adverse events compared to
seronegative persons (P<0.05). Despite a minor change in the
disease activity of patients with RA and SLE, disease activity indices
were overall stable in the AIIRD patients. Conclusion: The BBIBP-CorV
vaccine is effective in the development of neutralizing antibody in
immunosuppressed patients without considerable reactogenicity or
induction of disease flares.
A new rupicolous species from western Turkey: Stachys cuhacioglui (Lamiaceae)
Authors: Güner Özal , ÖZDÖL Tuğkan , YILDIRIM Hasan
Published: January 2024

Stachys is one of the most diverse genera of the family Lamiaceae and
currently consists of 360 species. Stachys species exhibit high
morphological variability and are distinguished using indumentum, calyx
and corolla length, tooth-to-calyx ratio and verticillaster arrangement.
Here, based on morphological and micromorphological studies, Stachys
cuhacioglui Yıldırım & Ö.Güner (Lamiaceae) described as a new species.
The new species was collected from İzmir province in SW Anatolia,
Turkey. Stachys cuhacioglui differs from S. annua complex in cordate
basal leaves, campanulate calyx, recurved calyx teeth, shorter calyx
(6–7 mm long) and shorter corolla (8–9 mm long). Description,
etymology, phenology, geographical distribution, IUCN threat category
and ecology of the new species are given.
Proteomics and bioinformatics investigations to improve serological diagnosis of canine brucellosis
Authors: Luciani Mirella , Krasteva Ivanka , Febo Tiziana Di , Perletta Fabrizia , D'Onofrio Federica , Massis Fabrizio De , D'Alterio Nicola , Sacchini Flavio , Tittarelli Manuela
Published: January 2024

Brucella canis is pathogenic for dogs and humans. Serological diagnosis
is a cost-effective approach for disease surveillance, but a major
drawback of current serological tests is the cross-reactivity with other
bacteria that results in false positive reactions, and development of
indirect tests with improved sensitivity and specificity remain a
priority. A western blotting assay was developed to define the serum
antibody patterns associated to infection using a panel of positive and
negative dog sera. B. canis positive sera recognized immunogenic bands
ranging from 7 to 30 kDa that were then submitted to ESI–LC-MS/MS and
analyzed by bioinformatics tools. A total of 398 B. canis proteins were
identified.. Bioinformatics tools identified 16 non cytoplasmic
immunogenic proteins predicted as non-homologous with the most important
Brucella cross-reactive bacteria and 9 B. canis proteins non-homologous
to B. ovis; among the latter, one resulted non-homologous to B.
melitensis. The western blotting test developed was able to distinguish
between infected and non-infected animals and may serve as confirmatory
test for the serological diagnosis of B. canis. The mass spectrometry
and in silico results lead to the identification of specific candidate
antigens that pave the way for the development of more accurate indirect
diagnostic tests.
Potential value of efficacy prediction and treatment of NK cells in extensive stage small cell lung cancer
Authors: Cui Yanan , Zhao Peiyan , Cheng Ying , Ren Xiubao
Published: January 2024

Although the emergence of immunotherapy has broken the deadlock of
extensive stage small cell lung cancer (ES-SCLC), the study of markers
for predicting efficacy is the key to the breakthrough of immunotherapy,
and exploring more innovative, efficient and safe treatment models is
also an important research direction of ES-SCLC. As an important part of
inherent immunity, natural killer (NK) cells have become a hot spot
because activated NK cells can directly kill tumor cells and may also
influence tumor microenvironment (TME) immunomodulation. To date,
emerging experimental research about NK cells in tumor therapy and
immuno-regulation has been published, but specific reviews of its role
in ES-SCLC were limited. Hence, in this review, we briefly summarized
the current status of immunotherapy and the exploration of biomarker in
ES-SCLCs, with focus on the potential value of efficacy prediction and
treatment of NK cells, and finally discuss the limitations and
development prospects of NK cells in ES-SCLC immunotherapy research.
Understanding Impacts of a Ransomware on Medical and Health Facilities by Utilizing LockBit as a Case Study
Authors: Khan Mohammed Rauf Ali
Published: January 2024

All forms of data are meant to be secured. The rise in cyber-crime since
beginning of the pandemic and the emergence of a variety of techniques
and tactics utilized by malware authors has made identification and
recovery difficult. LockBit ransom-ware has been in news in recent
times. The APT behind deployment of this ransom-ware virus has
compromised several organizations and the impacts are, worth more than
millions, lives of people by stealing their personal identifiable
information. It is important to understand the behavior of such malware,
to block it and to identify the anti-analysis stuff it performs. The
challenges here were a packed sample, a rebooting command-line trigger
and encryption of several files that can possess high trouble to
operations of any workplace.
Systematic significance of GC-MS analysis of Monodora Dunal. (Annonaceae) from Nigeria and the Cameroons
Authors: Adeniran Sunday , Kadiri Akeem , Olowokudejo James
Published: January 2024

The comparative assessment of six (6) Monodora species occurring in
Nigeria and the Cameroons was undertaken using GC-MS analysis. The
analysis was carried out with methanol extract and one hundred and sixty
(160) phytoconstituents were identified and scored at different
retention times ranging from 3.14min to 34.69min in M. undulata (P.
Beauvois) Couvreur. The results of the phytochemical constituents using
methanol extract of the genus Monodora were 16.85%, 10.67%, 32.58%,
9.55%, 16.85% and 13.48% of M. angolensis Welw., M. brevipes Benth.,
M. crispata Engl. & Diels., M. myristica (Gaertn.) Dunal., M. zenkeri
(Engl.) Dyer., and M. undulata respectively. The prominent compounds
were scored in carboxylic and its derivates while the least compound was
identified in alcohol and organo-compounds. Highest M.wt. was 611.62
scored M. angolensis at a retention time of 29.86 min and the lowest
M.wt. was 83.13 in M. zenkeri at a retention time of 13.14 min. In UPGMA
distant tree was constructed with an RMSD index to illustrate the
relationships among the Monodora species based on the different chemical
constituents. The scoring of two compounds named Heptasiloxane,
1,1,3,3,5,5,7,7,9,9,11,11,13,13-tetradecamethyl- and Octasiloxane,
1,1,3,3,5,5,7,7,9,9,11,11,13, 13,15,15-hexadecamethyl supported the
cluster of M. myristica, M. undulata, M. angolensis and M. crispata. The
highest distance value was between M. angolensis and M. myristica while
the highest similarity level was scored in M. brevipes and M. zenkeri,
which form a sub-cluster tree between M. zenkeri and M. brevipes. The
overlapping phyto-constituents characters revealed the closeness of the
taxa studied
A study of the efficacy and safety of plaque psoriasis treatment by TNF- α and IL-17A inhibitor biologics in patients who received the inactivated SARS-CoV-2 vaccine
Authors: YE Shuhong , Hong SUN , Jiawen WU , Zining XU , Bingyang XU , WU Na
Published: January 2024

ABSTRACT: Backgr ound : Vaccination is an important method for the
prevention of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) transmission. There is currently a lack of real-world
clinical data regarding the safety and efficacy of coronavirus disease
2019 (COVID- 19) vaccines with respect to plaque psoriasis treatment
involving tumor necrosis factor (TNF)-α and interleukin (IL)- 17A
inhibitors. Method s: We longitudinally analyzed 152 patients with
plaque psoriasis, 86 of whom received two doses of inactivated COVID- 19
vaccine (either BBIBP-CorV or CoronaVac). Comparisons were made between
patients undergoing treatment with biologics (TNF- α inhibitors or IL-
17A inhibitors) or acitretin. Routine blood tests were used to assess
safety; the psoriasis area and severity index (PASI) and dermatology
life quality index (DLQI) were used to assess efficacy. Results: After
inactivated COVID- 19 vaccination, biologics retained considerable
advantages in terms of improving skin lesions (measured by PASI) and
quality of life (measured by DLQI), compared with conventional treatment
(p<0.05 and p<0.01, respectively). Routine blood
tests and hepatorenal function analyses suggested that inactivated
SARS-CoV-2 vaccines did not alter the safety of biologics treatment
(p>0.05). Conclusions: Inactivated SARS-CoV-2 vaccines do
not have significant impacts on the safety and efficacy of biologics
(TNF-α inhibitors or IL- 17A inhibitors) in patients with moderate to
severe plaque psoriasis.
AI based Approach for State of Charge Estimation of Batteries for EV Applications
Authors: Kumar Deepak , Rizwan M , Panwar Amrish K.
Published: January 2024

In recent years Electric Vehicles (EVs) have been recognized as the most
excellent substitute for petroleum and diesel-powered vehicles in the
automotive industry, practically contributing to almost zero carbon
emissions. Li-ion batteries (LIBs) are mainly utilized to power EVs, but
certain drawbacks include temperature dependency, sluggish charging,
battery ageing, etc. Estimating the state of charge is important to
improve the performance and robust utilization of LIBs. The state of
charge of lithium-ion batteries is directly related to their safety and
efficiency, while practical calculation remains challenging for
real-time applications. Here, this paper uses artificial neural
network-based machine learning and deep learning approaches to estimate
the battery state of charge. The battery parameters have been accurately
integrated as input for the models. The proposed model’s accuracy,
reliability, and robustness are evaluated using available datasets. The
mean absolute error was found in the range of 0.0030 to 0.0035, and root
mean square errors 0.0043 to 0.0047 were obtained at 0 and 10 °C
operating temperatures. The results demonstrate that the proposed model
achieves more satisfactory accuracy and robustness, which is essential
for the battery management system (BMS) to make accurate decisions.
MIF as a master regulator in macrophage-induced chemotherapy resistance in esophageal squamous cell carcinoma
Authors: Ren Yi Lin , Zang Yi Chen , Qi Li Wen , Wang Xue Li , a * Yu Fang Xie , Li Fan Ping , Li Ya , Xue Le Le , Yang Kai Ge , Wang Wei Nan , Zhao Meng Meng , Liu Jia , Luo Cheng Hua , Liang Wei Hua , Zhang Hai Jun , Shen Xi Hua , Zhou Wen Hu , Jing Fei , Chen Wei Gang , Gu Wenyi , Wang Liang Hai , Li Feng , Hu Jian Ming
Published: January 2024

Backgroun：Esophageal cancer is insidious, with recurrent
metastasis and chemotherapy resistance as primary reasons for treatment
failure. Recent interest has focused on the molecular mechanisms of
tumor-associated macrophages (TAMs) in the tumor microenvironment, which
remain largely unknown. Methods：TAMs were examined using both
in vitro and in vivo assays. Seventy-seven normal
paracancerous tissues and esophageal squamous cell carcinoma (ESCC)
tumor samples were compared using immunohistochemical methods. Molecular
mechanisms were identified using Transwell, Western blotting,
Fluorescence-assisted cell sorting, CCK 8, and reverse
transcriptase–polymerase chain reaction assays. Results: M2
TAMs were significantly elevated in ESCC tissues. M2 TAMs contributed to
ESCC development and resistance to treatment both in vitro and
in vivo. Elevated CD163 TAMs in patients with
ESCC correlate with an unfavorable prognosis. We found that TAMs release
macrophage migration inhibitory factor (MIF), which regulates the
expression of B-cell lymphoma 2 (Bcl-2), P-glycoprotein 1 (P-gp), and
Bcl-2 associated X (Bax) to promote drug resistance and stimulate
phosphoinositol 3-kinase (PI3K)–protein kinase B (AKT) signaling.
Conclusion:Our findings demonstrate that MIF performs a
functional role in the macrophage-mediated resistance of ESCC cells to
cisplatin and that targeting MIF may serve as a strategy for molecular
therapy.
Levels of CC motif chemokine 22 (CCL22), IL-13, and CXCL10, but not levels of IL-5, predict response to mepolizumab in asthma
Authors: Akenroye Ayobami T. , Nopsopon Tanawin , Hacker Jonathan , Laidlaw Tanya M.
Published: January 2024

To date, most studies of response to the anti-interleukin 5 agent,
mepolizumab, has identified eosinophils as the main clinical biomarker
of response. However, many patients with eosinophilic asthma still fail
to demonstrate clinical response to mepolizumab. In this study, we
evaluate the association of 26 cytokines and chemokines, including
T-helper 1 (Th1)-, Th2-, Th17-related cytokines and alarmins, with
response to mepolizumab. We defined clinical response to mepolizumab as
a reduction in the baseline annual exacerbation rate by at least half
over the one-year period following initiation of mepolizumab. Our
results suggest that, asides the peripheral eosinophil count, the levels
of the CC motif chemokine 22 (CCL22), IL-13, and CXCL10, but not levels
of IL-5, were higher in responders. These three and IL-17F, IL-23, and
IL-8 had the greatest differential between responders and nonresponders
to mepolizumab. Cytokines and chemokines associated with airway
eosinophilia, such as CCL22 and CXCL10, may be better predictors of
clinical response to mepolizumab than IL-5, the target of mepolizumab.
Centaurea osmaniyensis (Asteraceae), a new species from South Anatolia, Türkiye
Authors: İlçim Ahmet , demir berna
Published: January 2024

A new species, Centaurea osmaniyensis (Asteraceae) was described and
illustrated here and is only known from Bahçe district in Osmaniye
Province in Türkiye. The species belongs to sect. Cynaroides Bunge and
it is closely related to C. regia subp. cynarocephala. The ecology and
phenology of new species, descriptions, images, the identification key,
seed, pollen micromorphology and the IUCN threat category of the new
species were presented. In addition, the geographical distribution of
Centaurea osmaniyensis and C. regia subp. cynarocephala were provided
MyEasyHeathcare: An efficient and secure three-tier blockchain-based healthcare system
Authors: Agrawal Kanika , Aggarwal Mayank , Tanwar Sudeep
Published: January 2024

Blockchain is emerging as a solution to secure healthcare records but
faces certain shortcomings like transaction time, execution time, gas
consumption, etc. The current article designed an extensive
blockchain-based healthcare system (MyEasyHeathcare) with reduced gas
consumption and execution time, along with enhanced security at three
levels. At the first level, the professionals and patients get
registered, which provides identity access management. Secondly,
authorization is required for each registered entity by the owners.
Lastly, the third level includes a doctor-patient relationship where a
specific patient is assigned to a particular doctor by the hospital’s
owner. The data is protected from the outer world and is preserved only
between the doctor and the patient. Moreover, to include the majority of
tasks for hospital management, the developed system incorporates a smart
contract to record seven different parameters for patient diagnosis by
physician and fifteen different parameters by a pathologist. The
designed system is evaluated for the amount of gas consumed and
execution cost to decide the usage in the real world; the results
testify the proposed system is useful in the real world.
Anion effects on spin crossover systems: from supramolecular chemistry to magnetism
Authors: Zhao Shengze , Zhou Huawei , Zhang Haozhe , Qin Chunyan , Li Yonghua , Wang Shi
Published: January 2024

The field of anion supramolecular chemistry has received more and more
attention in recent years. Anions with diverse types and geometries have
been widely used for the synthesis of ionic spin crossover (SCO)
complexes. This review is devoted to anion effects on the molecular,
supramolecular structures and magnetic properties of discrete SCO
compounds. Firstly, typical anions used in the synthesis of these
compounds are briefly summarized according to their various geometries.
This is followed by a collection of representative examples of
anion-based SCO compounds, whose SCO properties are analyzed in terms of
supramolecular interactions, geometry and charge of anions. In the third
part, anion effects on SCO complexes of different kinds of metal centers
and ligands are outlined and finally remarks on the synthesis new type
of ionic SCO complexes in the future are described.
QT Interval as an Atherosclerosis Indicator in Patients with Schizophrenia
Authors: Kapıcı Yaşar , Kapıcı Olga Bayar , Abuş Sabri , Örüm Mehmet Hamdi , Ayhan Selçuk , Bozkurt Mehmet , Özer Bilal , Tekin Atilla
Published: January 2024

Background: Patients with schizophrenia (SCZ) have a higher risk of
cardiovascular diseases and acute myocardial infarction than the average
population. Early diagnosis of SCZ patients with subclinical
atherosclerosis is great importance in reducing cardiovascular morbidity
and mortality. Carotid intima-media thickness (CIMT) is a well-studied
marker of early atherosclerosis. Methods: Fifty-one SCZ patients (20
females, 31 males) and 55 healthy controls (HCs) (25 females, 30 males)
were included in the study. Electrocardiography (ECG), lipid parameters,
hemogram, and biochemistry values of the participants were taken.
Low-density lipoprotein (LDL), high-density lipoprotein (HDL), fasting
triglycerides, and total cholesterol were measured. The arrhythmogenic
index of plasma (AIP) was analyzed. Results: The mean age was 36.64±7.81
years in the SCZ group and 38.50±7.29 years in the HCs group. QT
interval (p=0.035), CIMT-left (p=0.008), CIMT-right (p=0.002), fasting
triglyceride (p=0.005), AIP (p=0.005) in the SCZ group compared to HCs
(<0.001) was statistically higher, while HDL (p=0.003) was
statistically lower. According to Pearson correlation analysis,
CIMT-left was positively correlated with age and QT interval (r=0.568,
p<0.001 and r= 0.589, p<0.001, respectively).
CIMT-right value was also positively correlated with age and QT interval
(r=0.533, p<0.001 and r= 0.555, p<0.001,
respectively). QT interval positively and significantly predicted
CIMT-left and CIMT-right (p<0.001, β=0.549 and p=0.001 and
β=0.506 accordingly). Conclusion: Considering that antipsychotic
treatments can cause dyslipidemia, hyperglycemia, and being overweight,
efforts should be made to detect and correct these additional
cardiovascular risk factors early in SCZ patients.
Sensitive Versus Controlling Parental Behaviors Across Infancy: Does Gender Matter?
Authors: Tissot Hervé , Repond Gloria , Favez Nicolas
Published: January 2024

While research has shown that sensitive and controlling parenting
behaviors influence infant development, few studies have used a
micro-analytic approach to compare the frequency of occurrence of these
behaviors according to parent and child gender, and have examined how
these phenomena change during infancy. This study aimed to investigate
differences in the frequency of sensitive and controlling behaviors
during parent-child play according to parent gender, infant gender, and
time. Both parents of 67 families participated in dyadic play
interactions when their child was 3 (T1), 9 (T2), and 18 (T3) months
old. We took into account four types of behaviors: “observing and
validating the infant’s behaviors” and “sharing joint activities with
the child” were considered sensitive behaviors, whereas “stimulating
the child” and “interfering with the child’s interest” were
considered controlling behaviors. Results of generalized linear mixed
models showed that mothers at T1 showed more interference than fathers
did, whereas parents at T3 observed and validated girls less frequently
than they did boys. Time effects showed an increase in interference and
joint activities and a decrease in stimulation and observation, which
suggests that the type of controlling and sensitive behavior changes as
the child develops.
Toddler-Teacher Interaction and Teachers’ Sensitivity as Predictors of Toddler’s Development during COVID-19: Stability or Change over Time
Authors: Seo SoJung , Song JiYeon
Published: January 2024

This study examined the stability and change patterns among toddlers’
interactions with their teachers, teachers’ sensitivity, and toddlers’
development during the COVID-19 pandemic and the three plausible paths
were tested to identify which of the study variables affected the
developmental trajectories in toddlers over time. Sixty- three toddlers
and six head teachers from a childcare center in Korea were sampled. The
data on toddler-teacher interaction and teachers’ sensitivity were
collected by observation during free play using a camera, and the
toddler’s temperament and development were assessed by his or her
mother. Toddlers who had been actively involved in initiating their
verbal interactions with teachers showed more verbal interactions with
their teachers even after 4 months passed. Also, the study found that
the early (T1) social disposition of toddlers and the behavioral
interaction that toddlers had initiated with teachers revealed each of
the simultaneous, cumulative, and complex effects. These results support
the contention that the nature of interactions vary by contexts of
subject, time, and socio-history, and new competencies should be
required for teachers within the multi-faceted pandemic and its
ramifications on toddler development.
UNSW-NB15 Computer Security Dataset: Analysis through Visualization
Authors: Zoghi Zeinab , Serpen Gursel
Published: January 2024

Class imbalance refers to a major issue in data mining where data with
unequal class distribution can deteriorate classification performance.
The problem can become serious if multiple classes are assigned to a
single data point representing data overlap. This study aims to provide
a visual analysis of the UNSW-NB15 dataset to offer a deep insight into
the intricacies of the dataset and the issues that may lead the
data-driven models to demonstrate poor performance. A variety of
visualization methods such as bar chart, 3D and 2D scatter plots,
intercluster distance map, and parallel coordinate diagram are used to
evaluate the data for imbalanced and overlapping issues. Several scalers
and data transformation methods are implemented to address the
overlapping issue and the distance between class centroids was measured
by the Mahalanobis distance metric. The largest distance between the
class centroids represents the high efficiency of the corresponding
scalers and data transformers in dealing with the data overlap. The
results reveal that the robust scaler can address the data overlap in
binary class classification and the min-max scaler and power transformer
can perform effectively in multi-class classification with regard to
dealing with the overlapping issue.
Photoinduced metal-free decarboxylative transformations: rapid access to amines, alkyl halides and olefins
Authors: Luo Jiajing , Jing Dong , Lu Cong , Zheng Ke
Published: January 2024

Herein, we report an efficient photocatalytic startegy for the
decarboxylative transformations of redox-active esters to construct C=C,
C(sp3)–N, and C(sp3)-X bonds in a single-step. This operationally
simple method provides a straightforward access to a variety of
protected alkyl amines, alkyl halides and olefins under mild conditions
in the absence of metals and photocatalysts. The method can successfully
be applied to primary, secondary, and tertiary aliphatic carboxylic acid
derivatives. Mechanistic studies indicate that the charge transfer
complex (CTC) was formed by nBu4NI with redox-active esters, in which
the nBu4NI acted as both an iodine source and an effi-cient electron
donor.