bluuebunny/crossref_metadata_2025 huggingface dataset:
Soft Tissue Rheumatological Conditions of Patients Visited in An OPD of a Tertiary Care Hospital
Authors: Alam Zahangir , Barua Sunam Kumar , Mohajan Kishore
Published: May 2022

Background: Soft tissue rheumatological conditions are common but largely unexplored. So the objective of the present study was to see the different soft tissue rheumatological conditions presenting in OPD of a tertiary care center.

Materials and methods: Present observational study conducted on 62 patients visiting the Physical Medicine OPD, Chattogram Maa-O-Shishu Hospital for different soft tissue rheumatological conditions were included in the study. Study period was six months from January 2020 to June 2020. After informed written consent patients were introduced a questionnaire and data was collected. Non-probability sampling method was adopted for the study. Data was analyzed by SPSS-20

Results: Among 62 patients gender distributions of patients revealed male was 24(38.7%) and female was 38(61.3%) and age group showing 15(24.2%) patients were at <30 years, 15(24.2%) patients were at 31-40 years, 13(21.0%) patients were at 41-50 years, 9(14.5%) patients were at 51- 60 years, 9(14.5%) patients were at 61-70 years and 1(1.6%) patient was at >71 years age group. Regarding occupations of the study patients 35(56.5%) patients were service holder, 24(38.7%) were doing business, 1(1.6%) patients was farmer, 1(1.6%) was fisherman and 1(1.6%) patients was housewife. Among all 9(14.5%) patients had DM and same number of patients also has HTN. Diagnosis of the soft tissue rheumatological conditions revealed 13(21%) patients had panter fassitis, 1(1.6%) patient had achillis tendinitis, 4(6.5%) patients had patellar tendinitis, 6(9.7%) patients had trochantaric bursitis, 1(1.6%) had tennis elbow, 3(4.8%) had golfer elbow, 191.6%) had De Quarven’s tenosinovitis, 5(8.1%) patients had trigger finger, 18(29.0%) patients had bicep tendinitis, 4(6.5%) patients had suspinatus tendinitis, 5(8.1%) patients had retrocalcaneal bursitis and 1(1.6%) patient had prepatellar bursitis.

Conclusion: Soft tissue rheumatological diseases are common in OPD visits and needs proper attention for better patients care.

Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 11-13
Attitude and Knowledge towards COVID-19 Vaccination among Women in Chattogram, Bangladesh
Authors: Yasmin Farida , Aurora Aphrodity
Published: May 2022

Background: The COVID-19 pandemic is changing rapidly and requires different strategies to maintain clinical preventive services, including immunization. The authorized vaccines have shown to prevent severe illness and hospitalization from - COVID-19. However, knowledge and attitudes towards COVID 19 vaccinations among female populations are poorly understood. Thus, the study aimed to investigate knowledge and attitude towards COVID19 vaccinations in Bangladeshi women.

Materials and methods: A cross-sectional study was performed in Chittagong Medical College Hospital, Chattogram from 14 February to 16 February 2021. The study was conducted using a structured, pre-formed questionnaire containing informed written consent along with three sections, i.e. sociodemographic profile, knowledge and attitudes. All women who had come to take vaccine against COVID- 19 in this hospital during the study period were the study population. Women who were not agreed to take part in the study and having complications e.g. mental disorder, hearing difficulty or critically ill were excluded from the study. The final sample size was 225. Systematic random sampling was applied to select the study population.

Results: During the study, 43% cases belong to 40-49 years’ age group and 91% were from urban area. Regarding knowledge towards vaccination, 69% study group think vaccine can give complete protection from COVID-19 and 97% cases have knowledge that vaccine can reduce severity of COVID-19 but 6% didn’t sure about death cases from vaccination, 51% shows positive results regarding elder people are at high risk from vaccination than younger, 79% study group think people with comorbid diseases are at high risk from vaccination. Regarding attitude towards vaccination, 95% cases were taking their vaccine willingly followed by 2% women think vaccine may not effective against COVID-19, 12% think rich people need vaccine more than poor.

Conclusion: The COVID-19 pandemic is still experiencing worldwide disasters but a possible ray of hope for the future can be found with the COVID-19 vaccine. The findings recommend that immediate programs of health education and the respective health authorities should provide more accurate information. In order to decrease vaccine relief enabled and promoted by disinformation in the media, policymakers should take efforts to provide appropriate understanding, favorable attitudes and views of COVID-19 immunization.

Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 26-30
Correlation of Serum Parathyroid Hormone and Calcium Level among Pre- and Post-menopausal Women
Authors: Zaman Sadia Israt , Tabassum Humaira , Khan Asma , Shaila Umme
Published: May 2022

Background: Postmenopausal women are prone to osteoporosis due to estrogen deficiency.

Objective: The purpose of the present study was to assess the correlation between serum parathyroid hormone level and serum calcium level among pre- and post-menopausal women.

Methodology: This cross-sectional study was conducted in the Department of Physiology at Dhaka Medical College, Dhaka, Bangladesh during the period of January 2012 to December 2012. Women were selected from different areas of Dhaka city. Among them, postmenopausal women with age ranging from 50 to 60 years were taken as group A and apparently healthy premenopausal women with age ranging from 20 to 30 years were included as group B for comparison. Serum calcium and parathyroid hormone levels were estimated to assess the hormonal status in both groups.

Results: A total number of seventy (70) postmenopausal women with age ranging from 50 to 60 years and duration of menopause was more than one year. Thirty (30) apparently healthy premenopausal women with age ranging from 20 to 30 years with regular menstrual cycle. Correlation between parathyroid hormone with serum calcium was analyzed. In group A, serum parathyroid hormone showed negative correlation with serum Calcium (r= -0.161, p= 0.184) which was statistically non-significant relationship. In group B, serum parathyroid showed positive correlation with serum calcium (r=+0.232, p=0.218) which was statistically non-significant relationship.

Conclusion: In conclusion serum calcium is lower and serum parathyroid hormone is higher in postmenopausal women.

Journal of Current and Advance Medical Research, January 2022;9(1):16-20
Evaluation of Naso-facial proportion of the Face and Their Correlation in Bangladeshi Buddhist Rakhain Ethnic Males
Authors: Iqbal Mohammed , Nahar Nazmun , Rahman Kazi Md. Shahidur , Rahman Md Zamilur , Uddin SK Amin Mohi , Alam Mohammed Safiul , Alam Urmee
Published: May 2022

Background: The face and nasal dimensions are most important cephalometric parameters describing human morphology. Nose is the most important aesthetic unit of face. There is wide variation in size and shape of nose and face due to ethnic influences.
Objective: The purpose of the present study was to evaluate the naso-facial proportion of the face and their correlation in adult healthy Bangladeshi Buddhist Rakhain Ethnic males.
Methodology: This cross-sectional observational study was carried out in the Department of Anatomy, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January 2011 to December 2011 for a period of one (01) year. Adult Healthy Bangladeshi Buddhist Rakhain males with the age group of 18 to 30 years were included as study population.
Results: This study shows mean of nose width was 41.16 (±3.03) and mean of ¼ face width was 34.80(±1.70). This study shows nose width was 41.16 (±3.03) and ¼ face width was 34.80(±1.70).
Conclusion: It was observed that nose width was significantly wider than ¼ of face width in the adult healthy Bangladeshi Buddhist Rakhain. This parameter was the importance of using patients as observers, as well as clinicians, in facial attractiveness research.
Journal of Current and Advance Medical Research, January 2022;9(1):32-35
Somatosensory influence on postural response to galvanic vestibular stimulation
Authors: Hlavačka F , Horak FB
Published: May 2022

We investigated how postural responses to galvanic vestibular stimulation were affected by standing on a translating support surface and by somatosensory loss due to diabetic neuropathy. We tested the hypothesis that an unstable surface and somatosensory loss can result in an increase of vestibulospinal sensitivity. Bipolar galvanic vestibular stimulation was applied to subjects who were standing on a force platform, either on a hard, stationary surface or during a backward platform translation (9 cm, 4.2 cm/s). The intensity of the galvanic stimulus was varied from 0.25 to 1 mA. The amplitude of the peak body CoP displacement in response to the galvanic stimulus was plotted as a function of stimulus intensity for each individual. A larger increase in CoP displacement to a given increase in galvanic current was interpreted as an increase of vestibulospinal sensitivity. Subjects with somatosensory loss in the feet due to diabetes showed higher vestibulospinal sensitivity than healthy subjects when tested on a stationary support surface. Control subjects and patients with somatosensory loss standing on translating surface also showed increased galvanic response gains compared to stance on a stationary surface. The severity of the somatosensory loss in the feet correlated with the increased postural sensitivity to galvanic vestibular stimulation. These results showed that postural responses to galvanic vestibular stimulus were modified by somatosensory information from the surface. Somatosensory loss due to diabetic neuropathy and alteration of somatosensory input during stance on translating support surface resulted in increased vestibulospinal sensitivity.
Functional and structural pattern of arterial responses in hereditary hypertriglyceridemic and spontaneously hypertensive rats
Authors: Török J , Koprdová R , Cebová M , Kuneš J , Kristek F
Published: May 2022

It has been shown that endothelium-derived nitric oxide (NO) plays an important role in regulation of vascular tone in the prenatal and early postnatal period. The aim of this paper was to determine the reactivity and accompanying structural changes in thoracic aorta from 4-week-old spontaneously hypertensive rats (SHR) and rats with hereditary hypertriglyceridemia (hHTG) in comparison with age-matched normotensive controls. For functional studies thoracic aorta was excised, cut into rings and mounted in organ baths for measurement of isometric contractile force. For morphological studies cardiovascular system of rats was perfused with glutaraldehyde fixative (at 100 mm Hg) via cannula placed in the left ventricle. Morphological changes of thoracic aorta were measured using light microscopy. Systolic blood pressure (SBP) in SHR (98+/-1 mm Hg) did not significantly differ from that of age-matched control rats (95+/-4 mm Hg), but was slightly increased in hHTG rats (110+/-2 mm Hg, P<0.05). Heart weight/body weight ratio was higher in SHR and hHTG rats than in control group indicating the hypertrophy of the heart in both models of hypertension. Endothelium-dependent relaxation of aorta induced by acetylcholine was preserved in all groups and did not differ from that in control normotensive rats. The maximal isometric contraction of thoracic aorta to noradrenaline (NA) was reduced in hypertensive groups and the concentration-response curves to NA were shifted to the right indicating increased sensitivity of smooth muscle to NA. The values of wall thickness and cross sectional area as well as inner diameter of thoracic aorta in SHR and hHTG rats were significantly decreased in comparison to control groups. Endothelial dysfunction seems to be absent in all young rats before development of hypertension. In conclusion, our observations indicate that in early stage of experimental hypertension NO-dependent relaxation is preserved so that putative impairment of this function provides no significant pathogenic contribution to the onset of hypertension in these two experimental models.
Comparison of vascular function and structure of iliac artery in spontaneously hypertensive and hereditary hypertriglyceridemic rats
Authors: Čačányiová S , Cebová M , Kuneš J , Kristek F
Published: May 2022

The aim of this study was to compare the vascular reactivity and morphology of iliac artery (IA) in adult spontaneously hypertensive rats (SHR) and hereditary hypertriglyceridemic (hHTG) rats. The isolated rings of iliac artery (IA) from Wistar rats (controls), SHR and hHTG rats were used for measurement of relaxant responses to acetylcholine (ACh) and contractile responses to noradrenaline (NA). Morphological changes of IA were measured using light microscopy. Systolic blood pressure (BP) measured by plethysmographic method was increased in SHR approximately by 88 % and in hHTG rats by 44 % compared to controls. BP increase was accompanied by cardiac hypertrophy. In both SHR and hHTG groups (experimental groups) reduced relaxation to ACh and enhanced maximal contraction and sensitivity to adrenergic stimuli were observed. The sensitivity to NA in SHR was higher also in comparison with hHTG. Geometry of IA in both experimental groups revealed increased wall thickness and wall cross-sectional area, in SHR even in comparison with hHTG. Inner diameter was decreased in both experimental groups. Thus, independently of etiology, hypertension in both models was connected with impaired endothelial function accompanied by structural alterations of IA. A degree of BP elevation was associated with arterial wall hypertrophy and increased contractile sensitivity.
Kemampuan Penalaran Matematis Siswa ditinjau dari Gender
Authors: Prajono Rahmad , Rahmat Rahmat , Maryanti Era , Salim Salim
Published: May 2022

Tujuan penelitian ini yaitu untuk menganalisis profil kemampuan penalaran matematis pada siswa kelas VIII SMPN 10 Kendari berdasarkan perbedaan gender. Jenis penelitian ini menggunakan metode deskriptif dengan pendekatan kuantitatif dan dilengkapi dengan pendekatan kualitatif. Data kualitatif dalam penelitian ini adalah hasil wawancara terhadap siswa. Sedangkan data kuantitatifnya diperoleh dari hasil pemberian tes kemampuan penalaran matematis. Data-data ini direduksi dan dianalisis untuk menjawab fokus penelitian. Hasil penelitian ini menunjukkan: (1) secara umum kemampuan penalaran matematis pada siswa kelas VIII SMPN 10 Kendari dengan kategori sangat rendah, (2) berdasarkan jenis kelamin, kemampuan penalaran matematis siswa perempuan lebih baik dibandingkan siswa laki-laki, dimana persentase kemampuan penalaran matematis siswa yang berjenis kelamin laki-laki sebesar 47,62% dan persentase kemampuan penalaran matematis pada siswa perempuan sebesar 52,38%.
Analisis Kemampuan Representasi Matematis Peserta Didik dalam Menyelesaikan Masalah pada Materi Program Linier
Authors: Yuwono Timbul , Darmawan Anan , Suwanti Vivi
Published: May 2022

Abstrak. Representasi matematis merupakan kemampuan yang sangat penting dan harus dimiliki oleh peserta didik untuk mengoorganisasikan ide mereka dalam menyelesaikan suatu masalah atau soal. Penelitian ini bertujuan untuk menganalisis kemampuan representasi matematis peserta didik dalam menyelesaikan masalah pada materi program linier dan penyebab kesalahan peserta didik. Penelitian ini menggunakan jenis kualitatif deskriptif. Data dalam penelitian ini dikumpulkan dengan cara tes tulis, wawancara, dan dokumentasi. Subjek sebanyak 33 peserta didik kelas XI, sedangkan subjek wawancara yaitu 5 peserta didik yang diambil masing-masing 1 dalam setiap kategori menggunakan metode purposive sampling. Hasil penelitian menunjukkan bahwa kemampuan representasi matematis 4 peserta didik berkategori sangat tinggi, 5 peserta didik kategori tinggi, 9 peserta didik kategori sedang, 8 peserta didik kategori rendah, dan 7 peserta didik kategori sangat rendah. Secara keseluruhan kemampuan representasi matematis dalam menyelesaikan masalah indikator visual, teks tertulis, dan ekspresi matematis pada 4 tahapan Polya tergolong mampu dan dapat dilakukan dengan baik. Walaupun pada representasi ekspresi matematis ada beberapa langkah penyelesaian yang cenderung tidak mampu dilakukan yaitu pada fungsi kendala, fungsi optimum, dan nilai optimum.Kata Kunci: Menyelesaikan Masalah, Representasi Matematis, Tahapan Polya.
Tahap Berpikir Geometri Siswa SMA Berdasarkan Teori Van Hiele Ditinjau dari Perbedaan Gender
Authors: Amalliyah Nor , Dewi Nuriana Rachmani , Dwijanto Dwijanto
Published: May 2022

Abstrak. Geometri adalah salah satu bagian dari ilmu matematika yang mempelajari titik yang dapat membentuk garis, garis menjadi bidang yang menyusun bangun datar segi banyak untuk mengkonstruksi sebuah bangun ruang. Proses pembelajaran geometri diharapkan mampu meningkatkan ketelitian, kecermatan, pengetahuan, dan wawasan siswa dalam berpikir ilmiah khususnya pada siswa SMA. Guru perlu mengetahui tahapan berpikir geometri siswa agar dapat menentukan model pembelajaran yang tepat dan efektif. Oleh karena itu perlu diketahui tahapan berpikir geometri siswa yang ditinjau dari perbedaan gender. Jenis penelitian ini merupakan penelitian deskriptif kualitatif dengan 6 siswa SMA sebagai subjek yang terdiri dari 3 siswa perempuan dan 3 siwa laki-laki. Teknik pengumpulan data dilakukan dengan memberikan tes secara tertulis kepada siswa menggunakan instrumen Van Hiele Geometry Test. Hasil penelitian menunjukkan bahwa dari 6 siswa yang diteliti tahap berpikir siswa rata-rata berada pada tahap 1 (analisis). Gender berpengaruh terhadap tahap berpikir geometri siswa. Kemampuan berpikir geometri siswa perempuan berada pada level lebih tinggi dibandingkan dengan siswa laki-laki.Kata Kunci: Tahap Berpikir, Van Hiele, Gender
Analisis Bibliometrik Tren Penelitian Media Pembelajaran Google Classroom Menggunakan Aplikasi VOSViewer
Authors: Ajinegara Muhamad Wulidasauma , Soebagyo Joko
Published: May 2022

Abstrak. Perkembangan Pendidikan di Indonesia saat ini sudah mengacu kepada abad 21 yang ditandai perkembangan teknologi. Berkembangnya teknologi membuat proses pembelajaran online sangat mudah untuk digunakan. Google Classroom merupakan salah satu platform berasal dari Google yaitu layanan portal efisien yang memudahkan guru untuk mengelola buku teks dan tugas. Tujuan dari artikel ini adalah untuk memberikan gambaran yang luas analisis bibliometrik tentang media pembelajaran Google Classroom dengan menskrining 93 artikel yang telah dicari dengan menggunakan aplikasi Publish or Perish dan menganalisisnya dengan aplikasi VOSViewer serta menarik kesimpulan atas gambaran yang luas dari tujuan artikel. Terdapat 4 Clusters pengklasifikasian dengan VOSViewer. Hasil Penelitian didapat bahwa artikel yang digunakan dengan judul Google Classroom dan kata kunci “pendidikan”, dan “matematika” mulai meningkat pada tahun 2018, 2019, dan 2020 serta artikel yang paling banyak publikasi adalah negara Indonesia. Dari penelitian tersebut didapat 3 kluster mengenai media pembelajaran menggunakan Google Classroom dengan topik matematika pendidikan. Topik media pembelajaran Google Classroom sudah banyak dilakukan penelitian, namun untuk topik effect, impact, dan achievment sangat jarang dilakukan penelitian.Kata Kunci: Bibliometrik, E-Learning, Google Classroom, Matematika.
Facial Skin Color Segmentation Using Otsu Thresholding Algorithm
Authors: Rismayana Aris Haris , Alfianti Henny , Ramdan Dadan Saepul
Published: May 2022

The development of technology and information is currently very fast. One of the fields of technology and information that is experiencing development is the field of digital image processing. There are many technologies today that utilize digital images such as facial recognition, object detection and many others. Skin is one of the largest components of the human body. Currently, technology in the identification of skin color is widely used in recognizing the human race. In this study, skin color detection uses the YCbCr color space, which in this study only uses the range of Cb and Cr values, and ignores the Y value. Where Y is the lighting in the image. So if not changed, the image will contain light effects that can change the characteristics of skin color. However, problems were found because the detected images were not segmented properly, such as clothes and hair from the tested images were still detected as skin. Therefore, the HCbCr color space method is proposed where the Hue value will represent the color of visible light. While the Otsu Thresholding method will separate the background from the object in the digital image.
Cross-Language Text Document Plagiarism Detection System Using Winnowing Method
Authors: Mentari Mustika , Rozi Imam Fahrur , Rahayu Maria Puji
Published: May 2022

Currently, there are many text documents such as journals scattered on the internet, both Indonesian and English-language journals. With this, it is possible to act plagiarism by copying from foreign journals that are translated into other languages or copying directly without being changed from the original language. One way that can suppress these actions is to build a plagiarism detection system for cross-language text documents. The method that can be used to detect document plagiarism is the Winnowing method. Winnowing method is a method where text input will be processed to produce a hash value called a fingerprint. This study aims to build a system that can detect plagiarism of text documents in different languages using the Winnowing method. Text documents that can be tested are input text and PDF files. Documents used in system testing are journals that have the same topic. The results of the highest level of accuracy produced between the calculation of the Jaccard Coefficient with the Plagiarism Checker X application are in the fourth scenario with an average percentage value of 84.7%.
Management of Counseling Guidance in Handling Student’s Delinquency in Madrasah
Authors: Jarkawi Jarkawi , Madihah Husnul
Published: May 2022

This study aims to understand the management of counseling guidance in dealing with student delinquency in MTs Negeri 1 Banjarmasin City. Of the many student delinquency behaviors that occur at MTs Negeri 1 Banjarmasin City, the triggering factor is dominated by the influence of close friends, environment, and existence in the eyes of their friends. This study uses a qualitative case study type method. The data collection technique was carried out through interviews with the head of the madrasa, deputy head of the madrasa, counseling teachers and students, observation, and documentation. The data analysis is carried out in stages, starting from data presentation, data reduction, and concluding. The results showed that the planning of counseling guidance was based on the needs of students, parents, and madrasas, which was carried out systematically. Meanwhile, the implementation is carried out by referring to the standards set by the madrasa. The evaluation is carried out regularly every month, semester, and yearly to determine the extent of the success and obstacles of the guidance program. Through planned and systematic counseling, students will have a good and superior personality.
Tahfidz Al-Qur'an: A Study of Learning Management Systems in Higher Education
Authors: Thontawi Muhammad , MY Mahmud , Chaniago Fransisko , Fiqhi Ajuzar , Hazairin Indah Nurul , Afifah Yuliana
Published: May 2022

This study aims to analyze the implementation, evaluation, and management of the tahfidz Al-qur'an program at Ma'had Al-Jami'ah from the State Islamic University of Sulthan Thaha Saifuddin Jambi. The method used in this research is qualitative with a descriptive analysis method. Interviews were conducted directly with the leaders of Ma'had, the tahfidz division, and the mudabbir. The results showed that the management of the Tahfidz Al-Qur'an Program at Ma'had Al-Jami'ah was running well. This program was implemented thanks to the collaboration between the academic community and a facilitator called Mudabbir, who is responsible for optimizing the process of memorizing the Qur'an, and providing a greater understanding of the importance of memorizing the Qur'an for students by adjusting the components of planning, organizing, implementing, and evaluation of the Tahfidz Al-qur'an Program. Ma'had Al-jami'ah continues to make adjustments to improve the quality of graduates and equip them with a deep understanding of the meaning of the Qur'an to increase students' faith and piety.
Risk factors of severe acne vulgaris: Systematic review and meta-analysis
Authors: Gryazeva N. V. , Tamrazova A. V.
Published: May 2022

Severe forms of acne vulgaris are accompanied by a pronounced decrease in the quality of life and lead to scarring. Early and effective acne therapy is the prevention of the formation of persistent cosmetic defects.

Aim. To identify risk factors and predictors for the development of severe forms of acne vulgaris.

Materials and methods. Article searches were performed in PubMed, Google Scholar and the Cochrane Central Registry of Controlled Trials over the period from 15 years to 10/25/2021 for the keywords ‘severe acne’, ‘predictors’ and ‘risk factors’. A meta-analysis was prepared using the Review Manager software (RevMan 5.4.1), The Cochrane Collaboration (2020) in line with international guidelines for systematic reviews and meta-analyzes (PRISMA).

Results. 38 publications were included in the review. Risk factors for the development of severe forms of acne vulgaris can be divided into nonmodifable (presence of acne in close relatives, male gender, oily skin type, changes in genes) and modifable (increased BMI, consumption of dairy products, Fast digesting carbohydrates, etc.) In the meta-analysis, a statistically signifcant increase in the risk of severe forms of acne vulgaris in the presence of a history of acne in a close family member was found to be 2.54 times (95 % CI [1.63, 3.91]). It was also found that men have a higher risk of developing severe forms than women (1.16 times {95 % CI [1.04, 1.30]}). People with a BMI higher than 25 (2.54 times {95 % CI [1.63, 3.91]}) and those who consume dairy products 1.59 times more often than three times a week (95 % CI [1.37, 1.85]).

Conclusion. Understanding the main risk factors for the development of deep forms of acne vulgaris will help to suspect a severe course of the disease in the early stages and to prescribe effective therapy in time. Male gender, family history, elevated BMI, and dairy consumption suggest a high likelihood of early development of severe acne.
Systemic isotretinoin in treatment of severe seborrheic dermatitis
Authors: Markelova E. M.
Published: May 2022

The article presents the results of evaluating the effectiveness of isotretinoin as the main drug therapy in patients with persistent and severe forms of seborrheic dermatitis.

Materials and methods. 20 patients used systemic isotretinoin at a dose of 10 mg every second day for 12 weeks. The assessment of the quality of therapy was carried out by taking into account the dynamics of indicators at the 8th and 12th weeks. To assess the effectiveness of therapy evaluation scales of the dermatological index of the symptom scale and questionnaires of the dermatologists’ quality of life index DLQI (Dermatologists’ Quality of Life Index) were used.

Results. According to the assessment of the scale of the dermatological index of symptoms, the greatest effectiveness of the drug was manifested in a decrease in skin erythema as a percentage from 76% at the 8th week of treatment to 91% at the 12th week of treatment from their initial manifestations. In addition, a pronounced effect was found in indicators of itching symptoms from 83% to 97% and desquamation from 79% to 95%, respectively. In addition, based on the DLQI questionnaire (Quality of Life Index in Dermatology), the data obtained demonstrated a distinct improvement in the quality of life of patients: both at the 8th week of treatment and after completion of therapy at the 12th week. From 79% at week 8 to 97% after treatment.

Conclusions. The use of low doses of systemic isotretinoin proved to be an effective method of drug therapy for severe seborrheic dermatitis.
Investigation of the accuracy of determination of coordinates of location points by VLP-16 laser scanner installed on DJI S1000 UAV
Authors:   Lviv Polytechnic National University, HLOTOV V. , PETRYSHYN I. ,   MGGP
Published: May 2022

Goal. The aim of the work is to study the accuracy of determining the coordinates using a laser scanner laser scanner VLP-16 mounted on an octocopter DJI S1000. The authors implemented the technological scheme of installation of the VLP-16 laser scanner on the DJI S1000 octocopter and the method of studying the accuracy of determining the spatial coordinates of the points of objects with a laser scanner. The Department of Photogrammetry and Geoinformatics has developed a high-tech integrated complex of UAVs helicopter type DJI S1000 with air laser scanner Velodyne Lidar VLP- 16. As a result of creation of a complex the completely unified system without additional manufacturing of precision details and knots is received. For the S1000 helicopter-type UAV, test flights were performed to determine the accuracy of the obtained spatial coordinates using a scanner mounted on the body of the octocopter, the results were respectively: mX = 0.04 m, mY = 0.03 m, mZ = 0.04 m. The obtained results should be applied to the complex for various topographic and applied problems. Results. The proposed complex was tested at the appropriate control points obtained during aeroscanning with UAVs at control points, which made it possible to justify the effectiveness of the proposed method. Scientific novelty. For the first time, a compact, active VLP-16 laser scanner was tested on an DJI S1000 octocopter UAV. Practical significance. The obtained data from laser scanning can be used to solve various engineering problems. Namely, the creation of 3D-models of architectural structures, determining the volume of quarries, creating digital models of engineering and transport infrastructure: power lines, infrastructure of roads and railways, reconstruction of architectural monuments, research of channel processes, quantitative determination indicators in forest assessment.
Fourth congress of UTGK
Authors:   Lviv Polytechnic National University, Thevoho I. , CHETVERIKOV B. ,   Lviv Polytechnic National University, KARPINSKYY Yu. ,   Research Institute of Geodesy and Cartography
Published: May 2022

The preparation and work of the IV Congress of the Public Union “Ukrainian Society of Geodesy and Cartography” (GS “UTGС”) which took place in Lviv on November 26, 2021 are considered. Information on organizational events, delegates and guests of the Congress, solemn and plenary sessions, reporting reports of the Presidium and the Audit Commission for 2017–2021 and evaluation of the Presidium of the UTGC; on the election of the President and the new composition of the Presidium and the Audit Commission of the UTGC for the period 2022–2026 and the adoption of the resolution of the IV Congress.
Analize of literature sources on the topic “Virtual geological outcrop”
Authors:   Lviv Polytechnic National University, OLIINYK M. , BUBNIAK I. ,   Lviv Polytechnic National University
Published: May 2022

The analysis of the literature sources concerning “virtual geological outcrop” is carried out. For this purpose, the scientometric databases Web of Science, Scopus, ScienceDirect were used, as well as the abstract journals RH “Geology”, RH “Geodezy” and the Ukrainian abstract journal “Dzherelo”. Trends in the use of photogrammetry and laser scanning for geological problems are analyzed.
The use of cartographic products in the development of national registers of cultural heritage
Authors:   Institute of Geography of NAS of Ukraine, POLYVACH K. , CHABANIUK V. ,   Institute of Geography of NAS of Ukraine, DYSHLYK O. ,   “Geomatic Solutions”, LLC, PIORO V. ,   NGO “Ukrainian center for museum development”
Published: May 2022

Goal. The goal of this paper is to consider the European and Ukrainian experience of using cartographic products in the development of national registers of the material cultural heritage (CH). Also, to identify the approach most appropriate for Ukraine. Methodology. It was previously proved that the current, feasible and “correct” model of the development of Spatial Data Infrastructures (SDI) of Ukraine should be product-process. This model is used in the analysis of European and Ukrainian experience. Results. Two approaches to the organization of such national registers have been set. The first can be called classical, according to which the registers must correspond to the product model of the development of Spatial Data Infrastructures (SDI). The second can be called non-classical, because the created registers must correspond to the process and more advanced models of SDI development. Scientific novelty. It has been proved for the first time that the future electronic State Register of the material CH of Ukraine must correspond to the product-process model of NSDI. Practical value. The obtained results can be used in the development of a real electronic State Register of the material CH of Ukraine. They are especially important for concept development of the future system.
PyZebrascope: An Open-Source Platform for Brain-Wide Neural Activity Imaging in Zebrafish
Authors: Barbara Rani , Nagathihalli Kantharaju Madhu , Haruvi Ravid , Harrington Kyle , Kawashima Takashi
Published: May 2022

Understanding how neurons interact across the brain to control animal behaviors is one of the central goals in neuroscience. Recent developments in fluorescent microscopy and genetically-encoded calcium indicators led to the establishment of whole-brain imaging methods in zebrafish, which record neural activity across a brain-wide volume with single-cell resolution. Pioneering studies of whole-brain imaging used custom light-sheet microscopes, and their operation relied on commercially developed and maintained software not available globally. Hence it has been challenging to disseminate and develop the technology in the research community. Here, we present PyZebrascope, an open-source Python platform designed for neural activity imaging in zebrafish using light-sheet microscopy. PyZebrascope has intuitive user interfaces and supports essential features for whole-brain imaging, such as two orthogonal excitation beams and eye damage prevention. Its camera module can handle image data throughput of up to 800 MB/s from camera acquisition to file writing while maintaining stable CPU and memory usage. Its modular architecture allows the inclusion of advanced algorithms for microscope control and image processing. As a proof of concept, we implemented a novel automatic algorithm for maximizing the image resolution in the brain by precisely aligning the excitation beams to the image focal plane. PyZebrascope enables whole-brain neural activity imaging in fish behaving in a virtual reality environment. Thus, PyZebrascope will help disseminate and develop light-sheet microscopy techniques in the neuroscience community and advance our understanding of whole-brain neural dynamics during animal behaviors.
Deep-Learning-Based Hemoglobin Concentration Prediction and Anemia Screening Using Ultra-Wide Field Fundus Images
Authors: Zhao Xinyu , Meng Lihui , Su Hao , Lv Bin , Lv Chuanfeng , Xie Guotong , Chen Youxin
Published: May 2022

Background:Anemia is the most common hematological disorder. The purpose of this study was to establish and validate a deep-learning model to predict Hgb concentrations and screen anemia using ultra-wide-field (UWF) fundus images.

Methods:The study was conducted at Peking Union Medical College Hospital. Optos color images taken between January 2017 and June 2021 were screened for building the dataset. ASModel_UWF using UWF images was developed. Mean absolute error (MAE) and area under the receiver operating characteristics curve (AUC) were used to evaluate its performance. Saliency maps were generated to make the visual explanation of the model.

Results:ASModel_UWF acquired the MAE of the prediction task of 0.83 g/dl (95%CI: 0.81–0.85 g/dl) and the AUC of the screening task of 0.93 (95%CI: 0.92–0.95). Compared with other screening approaches, it achieved the best performance of AUC and sensitivity when the test dataset size was larger than 1000. The model tended to focus on the area around the optic disc, retinal vessels, and some regions located at the peripheral area of the retina, which were undetected by non-UWF imaging.

Conclusion:The deep-learning model ASModel_UWF could both predict Hgb concentration and screen anemia in a non-invasive and accurate way with high efficiency.
Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals
Authors: Brischigliaro Michele , Badocco Denis , Costa Rodolfo , Viscomi Carlo , Zeviani Massimo , Pastore Paolo , Fernández-Vizarra Erika
Published: May 2022

The redox activity of cytochrome c oxidase (COX), the terminal oxidase of the mitochondrial respiratory chain (MRC), depends on the incorporation of iron and copper into its catalytic centers. Many mitochondrial proteins have specific roles for the synthesis and delivery of metal-containing cofactors during COX biogenesis. In addition, a large set of different factors possess other molecular functions as chaperones or translocators that are also necessary for the correct maturation of these complexes. Pathological variants in genes encoding structural MRC subunits and these different assembly factors produce respiratory chain deficiency and lead to mitochondrial disease. COX deficiency in Drosophila melanogaster, induced by downregulated expression of three different assembly factors and one structural subunit, resulted in decreased copper content in the mitochondria accompanied by different degrees of increase in the cytosol. The disturbances in metal homeostasis were not limited only to copper, as some changes in the levels of cytosolic and/or mitochondrial iron, manganase and, especially, zinc were observed in several of the COX-deficient groups. The altered copper and zinc handling in the COX defective models resulted in a transcriptional response decreasing the expression of copper transporters and increasing the expression of metallothioneins. We conclude that COX deficiency is generally responsible for an altered mitochondrial and cellular homeostasis of transition metals, with variations depending on the origin of COX assembly defect.
A New Strategy for Efficient Retrospective Data Analyses for Designer Benzodiazepines in Large LC-HRMS Datasets
Authors: Pan Meiru , Rasmussen Brian Schou , Dalsgaard Petur Weihe , Mollerup Christian Brinch , Nielsen Marie Katrine Klose , Nedahl Michael , Linnet Kristian , Mardal Marie
Published: May 2022

The expanding and dynamic market of new psychoactive substances (NPSs) poses challenges for laboratories worldwide. The retrospective data analysis (RDA) of previously analyzed samples for new targets can be used to investigate analytes missed in the first data analysis. However, RDA has historically been unsuitable for routine evaluation because reprocessing and reevaluating large numbers of forensic samples are highly work- and time-consuming. In this project, we developed an efficient and scalable retrospective data analysis workflow that can easily be tailored and optimized for groups of NPSs. The objectives of the study were to establish a retrospective data analysis workflow for benzodiazepines in whole blood samples and apply it on previously analyzed driving-under-the-influence-of-drugs (DUID) cases. The RDA workflow was based on a training set of hits in ultrahigh-performance liquid chromatography–quadrupole time-of-flight–mass spectrometry (UHPLC-QTOF-MS) data files, corresponding to common benzodiazepines that also had been analyzed with a complementary UHPLC–tandem mass spectrometry (MS/MS) method. Quantitative results in the training set were used as the true condition to evaluate whether a hit in the UHPLC-QTOF-MS data file was true or false positive. The training set was used to evaluate and set filters. The RDA was used to extract information from 47 DBZDs in 13,514 UHPLC-QTOF-MS data files from DUID cases analyzed from 2014 to 2020, with filters on the retention time window, count level, and mass error. Sixteen designer and uncommon benzodiazepines (DBZDs) were detected, where 47 identifications had been confirmed by using complementary methods when the case was open (confirmed positive finding), and 43 targets were not reported when the case was open (tentative positive finding). The most common tentative and confirmed findings were etizolam (n = 26), phenazepam (n = 13), lorazepam (n = 9), and flualprazolam (n = 8). This method efficiently found DBZDs in previously acquired UHPLC-QTOF-MS data files, with only nine false-positive hits. When the standard of an emerging DBZD becomes available, all previously acquired DUID data files can be screened in less than 1 min. Being able to perform a fast and accurate retrospective data analysis across previously acquired data files is a major technological advancement in monitoring NPS abuse.
One-Shot Full-Range Quantification of Multi-Biomarkers With Different Abundance by a Tandem Giant Magnetoresistance Assay
Authors: Meng Fanda , Zhang Lei , Lian Jie , Huo Weisong , Shi Xizeng , Gao Yunhua
Published: May 2022

In this study, we reported a tandem giant magnetoresistance (GMR) assay that realized the one-shot quantification of multi-biomarkers of infection, C-reactive protein (CRP) with procalcitonin (PCT), and neutrophil gelatinase-associated lipocalin (NGAL), all of which could cover their clinically relevant concentration ranges under a different principle. In the presence of co-determined assay, we quantified these three biomarkers in undiluted human blood serum in a single test. The tandem principle, based on which quantification of CRP occurs, combines a sandwich assay and an indirect competitive assay, which allows for the discrimination of the concentration values resulting from the multivalued dose-response curve (‘Hook’ effect), which characterizes the one-step sandwich assay at high CRP concentrations. However, the entire diagnostically dynamic range, in the quantification of PCT and NGAL, was achieved by differential coating of two identical GMR sensors operated in tandem and by combining two standard curves. The sensor quantified low detection limits and a broader dynamic range for the detection of infection biomarkers. The noticeable features of the assay are its dynamic range and small sample volume requirement (50 μL), and the need for a short measurement time of 15 min. These figures of merit render it a prospective candidate for practical use in point-of-care analysis.
DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors
Authors: Wang Yi Zhe , Zhao Wei , Ammous Farah , Song Yanyi , Du Jiacong , Shang Lulu , Ratliff Scott M. , Moore Kari , Kelly Kristen M. , Needham Belinda L. , Diez Roux Ana V. , Liu Yongmei , Butler Kenneth R. , Kardia Sharon L. R. , Mukherjee Bhramar , Zhou Xiang , Smith Jennifer A.
Published: May 2022

Low socioeconomic status (SES) and living in a disadvantaged neighborhood are associated with poor cardiovascular health. Multiple lines of evidence have linked DNA methylation to both cardiovascular risk factors and social disadvantage indicators. However, limited research has investigated the role of DNA methylation in mediating the associations of individual- and neighborhood-level disadvantage with multiple cardiovascular risk factors in large, multi-ethnic, population-based cohorts. We examined whether disadvantage at the individual level (childhood and adult SES) and neighborhood level (summary neighborhood SES as assessed by Census data and social environment as assessed by perceptions of aesthetic quality, safety, and social cohesion) were associated with 11 cardiovascular risk factors including measures of obesity, diabetes, lipids, and hypertension in 1,154 participants from the Multi-Ethnic Study of Atherosclerosis (MESA). For significant associations, we conducted epigenome-wide mediation analysis to identify methylation sites mediating the relationship between individual/neighborhood disadvantage and cardiovascular risk factors using the JT-Comp method that assesses sparse mediation effects under a composite null hypothesis. In models adjusting for age, sex, race/ethnicity, smoking, medication use, and genetic principal components of ancestry, epigenetic mediation was detected for the associations of adult SES with body mass index (BMI), insulin, and high-density lipoprotein cholesterol (HDL-C), as well as for the association between neighborhood socioeconomic disadvantage and HDL-C at FDR q < 0.05. The 410 CpG mediators identified for the SES-BMI association were enriched for CpGs associated with gene expression (expression quantitative trait methylation loci, or eQTMs), and corresponding genes were enriched in antigen processing and presentation pathways. For cardiovascular risk factors other than BMI, most of the epigenetic mediators lost significance after controlling for BMI. However, 43 methylation sites showed evidence of mediating the neighborhood socioeconomic disadvantage and HDL-C association after BMI adjustment. The identified mediators were enriched for eQTMs, and corresponding genes were enriched in inflammatory and apoptotic pathways. Our findings support the hypothesis that DNA methylation acts as a mediator between individual- and neighborhood-level disadvantage and cardiovascular risk factors, and shed light on the potential underlying epigenetic pathways. Future studies are needed to fully elucidate the biological mechanisms that link social disadvantage to poor cardiovascular health.
Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases
Authors: Sonawane Abhijeet Rajendra , Aikawa Elena , Aikawa Masanori
Published: May 2022

Cardiovascular diseases (CVD) are diverse disorders affecting the heart and vasculature in millions of people worldwide. Like other fields, CVD research has benefitted from the deluge of multiomics biomedical data. Current CVD research focuses on disease etiologies and mechanisms, identifying disease biomarkers, developing appropriate therapies and drugs, and stratifying patients into correct disease endotypes. Systems biology offers an alternative to traditional reductionist approaches and provides impetus for a comprehensive outlook toward diseases. As a focus area, network medicine specifically aids the translational aspect of in silico research. This review discusses the approach of network medicine and its application to CVD research.