bluuebunny/crossref_metadata_2025 huggingface dataset:
Legal PROeducation: A Student’s View
Authors:   Chair of the Far Eastern Regional Branch of the Young Lawyers Union, Shutova Irina Yu.
Published: June 2024

Рurpose. In this article, the author analyzes the issues of improving Russian statehood and society in difficult socio-legal and economic conditions, and provides the results of a sociological study. Methodology: the research is based on the use of general scientific and special methods: analysis, synthesis, induction, formal legal, abstract logical, etc. Conclusion. Information technologies in the modern world are developing very quickly. The requirements for the level, quality of vocational education and depth of knowledge of in-demand professions in the labor market are increasing every time, resulting in the need to reform the education system. Scientific and practical significance. The result of the work was the author’s proposal to create individual educational trajectories in higher educational institutions.
On the Special Legal Regime of Financial Activities of the State in the Conditions of Economic Sanctions
Authors:   Head of the Department of Administrative and Financial Law of the Kazan Institute (Branch) of the All-Russian State University of Justice, Sattarova Nuria A.
Published: June 2024

The author substantiates the conclusion that the regime of international sanctions applied to Russia creates special conditions for the implementation of the financial activities of the state; emphasizes the need to strengthen financial sovereignty; directions for minimizing threats to financial security are proposed.
Reasons for Illegal Conduct of Taxpayers
Authors:   Postgraduate Student of the Department of Financial Law of the Kutafin Moscow State Law University, Sadovsky Danil S.
Published: June 2024

Paying taxes is a constitutional obligation of a citizen and expresses his contribution to the development of society. However, not all taxpayers are willing to pay taxes. At the same time, the illegal behavior of taxpayers cannot be explained by any one reason – it is caused by a whole set of reasons. The article describes these reasons, which are classified into the following groups: economic, moral and psychological, socio-cultural and political reasons. There are also peculiarities in the reasons for illegal behavior of taxpayers – large companies.
On the Theory of Deconcentration of Power
Authors:   Associate Professor of the Department of Theory and History of State and Law of the North Ossetian State University Named after Kosta Levanovich Khetagurov, PhD (Law), Basiev Marat S.
Published: June 2024

This article examines the issues of the theory of deconcentration in the domestic and foreign scientific literature. In this context, the author consistently examines the existing positions regarding the understanding of the category “deconcentration” and its relationship with the concept of “decentralization”, and also studies the types of deconcentration. In particular, it is noted that in the Russian legal system, unlike other countries, this term is not used. Thus, deconcentration as one of the factors of the organization of power has been reflected in France and Cambodia. However, despite the absence of mention in Russian legislation, this mechanism is widely used within the framework of the territorial organization of public administration. As for the literature, most researchers point out that deconcentration is one of the forms of decentralization of public power. At the same time, among other manifestations of the latter, it is characterized by the least degree of autonomy of local government structures. The author understands by deconcentration the movement of the central government to the periphery through the formation of territorial subjects (or the empowerment of local subjects) as agents (representatives) of the central government, characterized by relations of power and subordination and not involving the creation of a separate level of public authority. The article also touches upon the issue of classification of the types of the analyzed legal phenomenon.
Political and Legal Principles of Combating Falsification of History (on the Example of the Battle of the Caucasus)
Authors:   Professor of the Department of Theory and History of State and Law of the North Caucasian Institute of Mining and Metallurgy (State Technological University), Chedzhemov Sergey R.
Published: June 2024

The article is devoted to countering the falsification of the national history of the state and law, in particular the Great Patriotic War on the example of the battle for the Caucasus. This topic still needs careful study, as new facts about it appear, and modern events are largely due to the events of those years. This makes it possible to reveal the interdependence of the domestic and foreign policy of our country and to debunk fabrications aimed at rehabilitating Nazism and belittling the role of the Soviet Union and its peoples in achieving victory in World War II. The author proposes, using the legal potential of the amendment made to the text of our Constitution - Art. 67.1, in the name of ensuring the protection of historical truth, not to allow the significance of the feat of the people in the defense of the Fatherland to be diminished and in this matter for legal purposes to use the possibilities of sanctions of Art. 354.1 of the Criminal Code of the Russian Federation to those who deny the facts established by the verdict of the International Military Tribunal in Nuremberg and spread false information about the Great Patriotic War, its events and its characters.
A Local Community as a Civil Society Institution and a Subject of Local Self-Government: Public Law Aspects
Authors:   Professor of the Vitruk Department of Constitutional Law of the Russian State University of Justice, LL.D., Professor, Pisarev Aleksandr N.
Published: June 2024

In the light of recent constitutional and legislative innovations regarding the legal regulation of civil society as a whole, and in particular of its individual public law institutions, as well as the legal position of the Constitutional Court regarding the recognition of the local community as a subject and source of local self-government, the concept and content of the legal definition of “local community” as a category are analyzed the sciences of municipal law and the legal institute of the eponymous branch of law. In order to clarify the concept of a local community as a subject of local self-government and formulate proposals for its legal regulation in the current legislation, the main elements (institutions) that make up its structure are highlighted, as well as the forms of interaction of the local community with local self-government bodies.
The Migration Policy of the Russian Federation in the Contemporary Conditions: Implementation Improvement Areas
Authors:   ostgraduate Student of the Department of Public Law of the Saint Petersburg State University of Aerospace Instrumentation, Bulatov Timur R.
Published: June 2024

The article discusses the directions of migration policy of Russia at the present stage. The problems of its implementation have been identified and proposals have been developed aimed at improving the state's policy in the field of migration; at overcoming the crisis stage in the development of our state in the political and socio-economic spheres caused by the impact of the sanctions policy of the United States and the West; at developing international relations in the field of migration within the Eurasian Economic Union and the BRICS countries.
On Means of Economic Encouragement of Investors in Complex Territorial Development
Authors:   Postgraduate Student of the Institute of Legislation and Comparative Law under the Government of the Russian Federation, Maksimkina Yulia A.
Published: June 2024

Based on the results of the issue, the author concludes that benefits for integrated development territory projects are practically reduced to zero, and at the same time those government support measures that can be used by investors require serious legislative changes. However, to solve this problem, the author proposes to amend Art. 286.1 of the Tax Code of the Russian Federation, amend the Federal Law “On public-private partnerships, municipal-private partnerships in the Russian Federation and amendments to certain legislative acts of the Russian Federation”, to the Federal Law of 04/01/2020 No. 69-FZ “On the protection and promotion investments in the Russian Federation” in terms of providing investors with the opportunity to enter into administrative agreements to co-finance the construction of social infrastructure, networks, roads, and also amend SanPiN 2.2.1/2.1.1.1200-03 in terms of providing investors with the opportunity to independently remove irrelevant sanitary protection zones, as well as the adoption at the level of regional regulations of provisions on reducing rent under a land lease agreement for the purpose of integrated territory.
State Regulation of Fishing in the Russian Federation from the Economic Security Perspective
Authors:   Associate Professor of the Department of Administrative Law and Customs of the Transbaikal State University, Associate Professor, PhD (Economics), Alpatkina Ekaterina S.
Published: June 2024

The article studies in detail methods of the state regulation of fishing in Russia: measures of fishing fleet support, encouragement of export of Russian fish, protection of the domestic market against undue import, artificial breeding results. The author analyzes customs regulation tools. The paper presents an evaluation of results of application of investment quotas in the industry.
El non bis in idem en los regímenes punitivos a los que se someten los servidores públicos en Colombia: ¿una garantía, en la práctica, inexistente?
Authors: Molina Otero María Raquel
Published: June 2024

La jurisprudencia colombiana ha defendido una posición sólida y reiterada respecto a la aplicación de la garantía del non bis in idem en los regímenes punitivos a los que se someten los servidores públicos, que se ha mantenido prácticamente incólume desde los primeros pronunciamientos de las altas cortes en el siglo XIX. En este escrito nos preguntamos si esta postura, aun­que sólida y reiterada, es adecuada.
Examining the Unfolding of Disciplinary Proceedings from Various Perspectives within the Context of Belgian and European Law
Authors: Wolf Daniel de , Eggermont Frederic , Timbermont Evelien
Published: June 2024

La exploración del derecho y los procedimientos disciplinarios revela una naturaleza compleja, con incertidumbres derivadas de la aplicación de garantías esenciales y desafíos planteados por la no aplicabilidad de ciertos principios como el derecho a permanecer en silencio y el principio de non bis in idem. La jurisprudencia en evolución en Bélgica sobre la conducta del peticionario durante las apelaciones administrativas, que se extiende más allá de los casos disciplinarios, plantea preguntas sobre la viabilidad de res­tringir el acceso al tribunal basado en el comportamiento de una parte. La Directiva de Protección a Denunciantes señala avances en el establecimiento de normas comunes en los países de la UE, ofreciendo amplia protección a diversas personas vulnerables a represalias laborales. Aunque la directiva carece de orientación específica sobre sanciones, es esencial contar con sanciones eficaces, proporcionadas y disuasorias.
Fondamenti teorici della responsabilità dei magistrati
Authors: Longhi Luca
Published: June 2024

En este artículo intentaremos reflexionar sobre los fundamentos de la res­ponsabilidad de los magistrados, en relación con la correspondencia entre poder y responsabilidad en el Estado de derecho, y en particular sobre la legitimación del poder judicial en el marco institucional actual. Se hará refe­rencia específica al ordenamiento jurídico italiano, intentando, sin embargo, permanecer en un nivel predominantemente abstracto, para llevar a cabo, en la medida de lo posible, consideraciones que también sean válidas a un nivel más general, relacionadas con la necesidad de más y mejores mecanismos de responsabilidad para los jueces y de reformas orgánicas para consolidar la credibilidad de los poderes públicos.
La subsanación de la infracción en el procedimiento sancionador de la Contraloría General: una reflexión desde el principio de buena administración en el derecho peruano
Authors: Castañeda Hidalgo André Jesús
Published: June 2024

El presente escrito busca aportar una interpretación a la causal atenuante de responsabilidad administrativa consistente en la subsanación voluntaria de la infracción. Para ello, se toman en cuenta los principios de razonabilidad, buena administración y de lucha contra la corrupción como un principio de carácter constitucional, lo que justifica distanciarse de la regulación esta­blecida en la Ley del Procedimiento Administrativo General. Este análisis se efectúa a la luz del interés público que persigue el procedimiento admi­nistrativo sancionador por responsabilidad administrativa funcional.
La promoción del deporte en el derecho internacional europeo. Antecedentes y armonización mediante el soft-law
Authors: González Pérez Álvaro
Published: June 2024

En el presente trabajo se investiga la evolución del derecho internacional en lo que respecta a la promoción del deporte. De esta forma se pretende analizar cómo los poderes públicos en el ámbito europeo han ido asumien­do paulatinamente la promoción del deporte en colaboración con el sector privado. Para ello se explica el desarrollo de la corriente cultural que reivin­dica el deporte como un derecho de los ciudadanos y los pronunciamientos internacionales de ámbito europeo que han dado respuesta a esta demanda popular, finalizando con una reflexión sobre la existencia del derecho inter­nacional deportivo como ordenamiento jurídico autónomo.
Microwave-Assisted Hydrolysis of Robusta Coffee Skin Waste as a Reducing Sugar Feedstock
Authors: Iriel Khairur Rahman Ilyas , Mizan Mizanurafi’ Ghifarhadi Prasiefa , M. Iqbal Samudra
Published: June 2024

The hydrolysis process is a process of breaking down substances by reacting using water, the aim is to break down the substance. This research focuses on the hydrolysis process to determine the reducing sugar content of coffee parchment. The method used is microwave-assisted hydrolysis. This method can increase lignin release more effectively than conventional cellulose and hemicellulose hydrolysis methods. The most commonly used hydrolysis to hydrolyze cellulose is acid hydrolysis. This research uses coffee parchment raw material (horn skin) which contains cellulose and hemicellulose with HCl solvent. Hydrolysis with acid concentration is (1, 2, and 3 %), microwave power (150, 300, and 450 W), and time (20, 25, and 30 minutes). In this study, the optimal reducing sugar yield was 8.054 g/mL under the operating conditions of 25 minutes, 3 % HCl concentration, and 450 W microwave power.
Extraction of Turmeric Leaves (Curcuma longa L.) as a Natural Preservative for Tuna Fish Using Ultrasound-Assisted Extraction (UAE) Method
Authors: Salma Isni Salma Salsabillah , Rossi Agnessi Pebriana  , Bekti  Palupi  , Ditta Kharisma Yolanda Putri  , Istiqomah Rahmawati
Published: June 2024

Turmeric leaves (Curcuma longa L.) contain phytochemical compounds that can be utilized as natural food preservatives or bioformalin due to its antibacterial properties. The extraction method used in this study is Ultrasound-Assisted Extraction (UAE), with the aim to determine the effect of variable sample-solvent ratio, time, and particle size on total flavonoid, tannin, and alkaloid compounds, as well as to determine the optimal shelf life of fresh tuna. This study used sample-solvent ratio variables of 1:10, 1:15, and 1:20; time variables of 10, 20, and 30 minutes; and particle size variables of 60, 80, and 100 mesh. The highest total flavonoid compound was obtained in the variable sample-solvent ratio of 1:20, particle size of 100 mesh, and time of 20 minutes at 98,076 mg/L. The highest total tannin compound was obtained in the variable sample-solvent ratio of 1:15, particle size of 60 mesh, and time of 10 minutes at 41,697 mg/L. The highest total alkaloid compound was obtained in the variable sample-solvent ratio of 1:10, particle size of 100 mesh, and time of 20 minutes at 10,092 mg/L. The optimum curing time for tuna is 36 hours at room temperature with variable sample-solvent ratio, time, and particle size of 1:20 g/mL, 20 minutes, and 100 mesh with 20% concentration. The running has the highest flavonoid compounds, so it can be concluded that flavonoid compounds have a major effect on the preservation process of tuna.
Ekstraksi Antosianin Buah Naga Menggunakan Metode Solvent Extraction
Authors: Rohman Yulianto Mohammad Fathur , Devina Shariska Putri
Published: June 2024

Kulit buah naga mengandung antosianin 26,4587 mg/L. Antosianin memiliki manfaat seperti zat pewarna alami pada bidang pangan dan dijadikan alternatif pengganti pewarna sintetis yang tentunya juga lebih aman untuk kesehatan. Tujuan penelitian ini untuk mengetahui pengaruh variabel ekstraksi(waktu, konsentrasi pelarut, dan ukuran partikel) terhadap kadar antosianin kulit buah naga dari hasil ekstraksi dengan metode Solvent Extraction. Secara umum pengertian dari Solvent Extraction adalah teknik pemisahan satu atau beberapa bahan dari suatu padatan atau cairan dengan bantuan pelarut. Jadi, Solvent Extraction adalah pemindahan zat terlarut (solute) diantara 2 pelarut yang tidak saling campur.Proses ekstraksi bermula dari penggumpalan ekstrak dengan pelarut kemudian terjadi kontak antara bahan dan pelarut sehingga pada bidang datar antarmuka bahan ekstraksi dan pelarut terjadi pengendapan massa dengan cara difusi. Proses ekstraksi bermula dari 25 gram bubuk kulit buah naga dengan variasi ukuran partikel (30, 60, dan 80 mesh) kemudian dimasukkan ke dalam tabung erlenmeyer. Kemudian dimasukkan larutan asam sitrat dengan variasi konsentrasi (0,1 M; 0,2 M; dan 0,3 M) sebanyak 250 ml. Setelah itu erlenmeyer diletakan di atas stirrer untuk melakukan pengadukan selama (90, 120, dan 150 menit).Setelah itu hasil ekstraksi disaring dengan menggunakan kertas saring sehingga menghasilkan filtrat. Kemudian filtrat diendapkan untuk mendapatkan ekstrak antosianin. Setelah itu dianalisa menggunakan metode spektrofotometri untuk menghitung kadar antosianin. Pada penelitian ini didapatkan hasil terbaik yaitu sebesar 11,439 mg/L. Dengan kondisi optimum ekstraksi pada ukuran partikel 60 Mesh, waktu 150 menit, dan konsentrasi pelarut asam sitrat 0,5 M.
APPLYING HYPERGRAPHS TO STUDIES IN QUANTITATIVE BIOLOGY
Authors:   ARC Centre of Excellence, Plant Success in Nature and Agriculture, School of Mathematics and Physics, University of Queensland, Brisbane, 4072, Australia, Barton Samuel , Coster Adelle ,   School of Mathematics & Statistics, The University of New South Wales, NSW 2052, Australia, Donovan Diane ,   ARC Centre of Excellence, Plant Success in Nature and Agriculture, School of Mathematics and Physics, University of Queensland, Brisbane, 4072, Australia, Lefevre James ,   ARC Centre of Excellence, Plant Success in Nature and Agriculture, School of Mathematics and Physics, University of Queensland, Brisbane, 4072, Australia
Published: June 2024

The objective of this research is to demonstrate hypergraph versatility and applicability for modeling diverse biological systems. The inherent structure of hypergraphs allows for encoding of higher-order feature interactions, providing a flexible framework for efficient models that can enhance our understanding of physical phenomena and one that can be generalized across various datasets. By adopting innovative methods including centrality measure and populations of models rather than singular instances, biases and overfitting tendencies are mitigated, again presenting promise for application across a broad spectrum of biological systems. Furthermore, emphasis is placed on the significance of probabilistic distribution analysis in elucidating threshold selection and feature relevance while maintaining high levels of accuracy. Our results demonstrate the advantages of hypergraph models on two different datasets; with the first on gene expression and the identification of outlier genes and the second on classifying starch grains. There is significant scope in the application of the hypergraph to a wider class of biological systems, with the potential to improve understanding of the biological processes.
Facies variability of the Lower Miocene Houthalen Member in the southern Genk municipality (northeastern Belgium)
Authors: DECKERS Jef , MUNSTERMAN Dirk , DE KONINCK Roel , SCHILTZ Marco
Published: June 2024

The Oligocene Eigenbilzen Formation and Miocene Bolderberg Formation were studied along the Albert Canal in the southern Genk municipality, eastern Belgium. Previous studies have subdivided the Eigenbilzen Formation into geophysical subunits based on borehole logs. Correlations of borehole logs with a deep Cone Penetration Test reveal that this subdivision is also geotechnically distinct. The Eigenbilzen Formation is unconformably overlain by the Houthalen Member (lower Bolderberg Formation), which holds a late Burdigalian age according to the dinoflagellate cyst analyses on borehole samples by this study. The average glauconite, organic and carbonate content of the Houthalen Member in the study area is 8.2%, 0.5% and 3%. Within the Houthalen Member, we distinguished two different geotechnical CPT and lithological facies, herein referred to as clayey and sandy facies. Granulometric analyses indicate that both facies are dominated by fine sands, however, with the sandy facies having an average 5.1% fine fraction (<63 µm), and the clayey facies 18.8%. The clayey facies is very distinct, whereas the sandy facies is geotechnically and granulometrically similar to the superjacent Genk Member (upper Bolderberg Formation). Besides carbonate content, the main difference between the sandy Houthalen Member and the Genk Member is the larger glauconite content of the first. As the glauconite content decreases upwards in the sandy Houthalen Member, it transitions into the Genk Member. Along the 3.6 km long correlation panel, the clayey Houthalen Member thins from over six meters in the southeast towards less than one meter in the northwest, which highlights the sedimentological complexity within the unit.
Mekanisme Restrukturisasi Produk Pembiayaan Kredit Usaha Rakyat (KUR) pada Bank Rakyat Indonesia Kantor Cabang Kebumen
Authors: Isnaeni Khosyati  , Annisa Rahima
Published: June 2024

Penelitian bertujuan mengetahui faktor-faktor yang menyebabkan timbulnya kredit bermasalah beserta mekanisme pemberian restrukturisasi pinjaman KUR pada BRI Kantor Cabang Kebumen. Faktor yang menyebabkan kredit bermasalah salah satunya penurunan pendapatan karena hasil usaha yang menurun, pemotongan gaji karyawan yang terdampak oleh Covid-19, dan pemutusan hubungan kerja debitur yang berpotensi memengaruhi kredit. Situasi ini dapat dianggap sebagai masalah kredit dikarenakan pinjaman yang telah diserahkan oleh bank tidak dapat dikembalikan sesuai dengan kesepakatan dalam perjanjian. Penelitian ini menggunakan metode analisis data kualitatif deskriptif. Hasil penelitian menyatakan bahwa pelaksanaan restrukturisasi kredit dengan menerapkan analisis kelayakan 5C dapat menjadi langkah penyelamatan yang efektif untuk menghindari kerugian akibat kredit bermasalah di BRI Kantor Cabang Kebumen sebagai pemberi pinjaman. Dalam pelaksanaannya, restrukturisasi harus mematuhi prinsip-prinsip manajemen risiko dan kehati-hatian. Nasabah yang memenuhi syarat untuk mendapatkan restrukturisasi adalah mereka yang masih memiliki potensi bisnis yang positif dan memiliki kemampuan untuk terus berkelanjutan dalam menjalankan usahanya.
Kata Kunci: Kredit Bermasalah, KUR BRI, Restrukturisasi
Assessment of Breeding Potential of Foxtail Millet Varieties Using a TOPSIS Model Constructed Based on DUS Test Characteristics
Authors: Yu Jin , Bai Xionghui , Zhang Kaixi , Feng Leyong , Yu Zheng , Jiao Xiongfei , Guo Yaodong
Published: June 2024

Foxtail millet (Setaria italica) is an important cereal crop with rich nutritional value. Distinctness, Uniformity, and Stability (DUS) are the prerequisites for the application of new variety rights for foxtail millet. In this study, we investigated 32 DUS test characteristics of 183 foxtail millet resources, studied their artificial selection trends, and identified varieties that conform to breeding trends. The results indicated significant differences in terms of means, ranges, and coefficients of variation for each characteristic. Correlation analysis was performed to determine the correlations between various DUS characteristics. Principal component analysis was conducted on 31 test characteristics to determine their primary characteristics. By plotting PC1 and PC2, all germplasm resources could be clearly distinguished. Trends in foxtail millet breeding were identified through differential analysis of DUS test characteristics between landrace varieties and cultivated varieties. Based on these breeding trends, optimal solution types for multiple evaluation indicators were determined; weight allocation was calculated, and a specific TOPSIS algorithm was designed to establish a comprehensive multi-criteria decision-making model. Using this model, the breeding potential of foxtail millet germplasm resources was ranked. These findings provided important reference for foxtail millet breeding in future.
Cultural Influences on Supply Chain Practices and Their Marketing Implications
Authors: Holloway Samuel
Published: June 2024

This qualitative research explores the intricate relationship between cultural influences on supply chain practices and their implications for marketing strategies. Cultural dimensions such as individualism versus collectivism, uncertainty avoidance, and contextuality significantly shape decision-making processes, risk management strategies, and relationship dynamics within global supply chains. Through semi-structured interviews with supply chain managers, marketing executives, and cultural experts across diverse industries and regions, this study investigates how cultural values impact supply chain operations and consumer engagement strategies. Key findings highlight that collectivist cultures prioritize consensus-building and long-term relationships, fostering trust and collaboration among supply chain partners. In contrast, individualist cultures emphasize efficiency and accountability but may face challenges in relationship building. Risk management practices vary with cultural orientations towards uncertainty, influencing the adoption of structured versus flexible approaches to mitigate disruptions. In terms of marketing implications, the study underscores the importance of cultural sensitivity in crafting effective strategies. High-context cultures require marketing messages that resonate emotionally through implicit communication and cultural symbolism, while low-context cultures prefer clear, direct messaging focusing on product benefits. The study concludes by advocating for cultural competence as a strategic imperative for global businesses, enabling them to leverage cultural diversity for innovation and competitive advantage. It emphasizes the need for continuous adaptation to cultural nuances and market dynamics to foster inclusive collaboration and achieve sustainable growth in a globalized economy.
Emerging Cationic Nanovaccines
Authors: Carmona-Ribeiro Ana Maria , Pérez-Betancourt Yunys
Published: June 2024

Nanovaccines are able to deliver antigen(s) and immunomodulator(s) directly to antigen-presenting cells (APCs) of the lymphatic system. Positive charges improve their uptake by APCs and often drive a Th-1 biased immune response so necessary against infectious diseases caused by intracellular pathogens and cancers. However, cationic compounds often display a dose-dependent toxicity so that systematic evaluation of cytotoxicity against cells in culture is required. After the rapid evolution of nanovaccines against SARS-Covid 2, mRNA vaccines gained much strength and have been designed against several infectious diseases, often relying on cationic components for mRNA protection. Once established the limiting concentration for the cationic compound, cationic nanovaccines perform well eliciting the desired Th-1 improved immune response in most cases. Other valuable approach found in the literature has been the construction of biocompatible nanoparticles (NPs) carrying cationic lipids, polymers or surfactants so that minimization of the concentration for the cationic component led to absence of toxicity. Against cancer, recent constructions of nanovaccines in situ after cancer cell disruption in the presence of adjuvants led to systemic presentation of multiple tumoral antigens yielding, in many instances, prevention of metastasis appearance and conversion of tumors non treatable by immunotherapy into treatable ones.
Percutaneous Thoracic Duct-Cistena Chyli Coil and Glue Embolization via Antgrade Sublumbar Cisterna Chyli Access in a Cat with Chylothorax
Authors: Wojciechowski Rafal Wit
Published: June 2024

An 8-year-old, entire male, Domestic Shorthair cat was presented due to acute onset of dyspnoea/tachypnoea. Thoracic x-ray revealed presence of significant amount of bilateral pleural effusion. Fluid analysis indicated chylous effusion. The CT examination revealed many thoracic and abdominal abnormalities without a clear explanation for chylothorax. CT-lymphangiogram followed by surgical management were recommended. These options were declined by the owner due to high cost, however, a consent was given for attempt at percutaneous thoracic duct embolization. A percutaneous access to the cisterna chyli was successfully performed with an 18G vascular access needle via a right-sided sublumbar approach under ultrasound guidance. Subsequently, a 3F microcatheter and a 0.014-inch guidewire were introduced through the needle to canulate the thoracic duct. Thoracic duct lymphangiography was performed with 50:50 iohexol: 0.9% sodium chloride mixture revealing presence of dilated, tortuous and leaky cranial mediastinal lymphatics. Two helical microcoils were deployed within the caudal thoracic duct. Embolization of both the thoracic duct and the cisterna chyli was completed with mixture of n-butyl-2-cyanoacrylate: ethiodized oil mixture in 1:2 (glue-to-oil) ratio using a ‘pull-back’ technique. The cat recovered uneventfully from the procedure with immediate resolution of chylothorax. However, the patient continued to suffer from non-chylous pleural effusion.
Globally Conditioned Conditional FLOW (GCC-FLOW) for Sea Clutter Data Augmentation
Authors: Lee Seokwon , Chung Wonzoo
Published: June 2024

In this paper, a novel deep learning approach based on conditional FLOW is proposed for sea clutter augmentation. Sea clutter data augmentation is important for testing detection algorithms for maritime remote sensing and surveillance due to the expensive and time-consuming nature of sea clutter data acquisition. While the conventional parametric methods face challenges in finding appropriate distributions and modeling time correlations of the sea clutter data, the proposed deep learning approach, GCC-FLOW , can learn the data distribution from the data without explicitly defining a mathematical model. Furthermore, unlike the existing generative deep learning approaches, the proposed GCC-FLOW is able to synthesize sea clutter data of arbitrary length with the stable autoregressive structure using conditional FLOW . In addition, the proposed algorithm generates sea clutter data not only with the same characteristics of the training data, but also with the interpolated characteristics of different training data by introducing a global condition variable corresponding to the target characteristic such as sea state. Experimental results demonstrate the effectiveness of the proposed GCC-FLOW in generating sea clutter data of arbitrary length under different sea state conditions.
Relação entre competência digital e letramento digital por meio de revisão de literatura
Authors: Luz Sandra Dias da , Lucas Elaine Rosangela de Oliveira
Published: June 2024

O avanço das Tecnologias Digitais de Informação e Comunicação (TDIC) na sociedade tem promovido mudanças significativas na Educação. Nesse sentido, o presente artigo objetiva revisar a relação entre dois dos seus principais termos da Cultura Digital, Competência Digital e Letramento Digital, ambos utilizados na literatura em Educação. Para isso, adotou-se como metodologia a pesquisa bibliográfica, a partir da base de dados Web of Science (WoS). O corpus de análise se concentrou em seis publicações. Os resultados revelam variações terminológicas e conceituais. O termo Competência Digital é a escolha para a construção de um vocábulo comum na busca por subsidiar formações de professores e políticas públicas, enquanto Letramento Digital aborda de forma mais ampla a temática, sendo mais utilizado em pesquisas acadêmicas. No Brasil,foi consolidado a adoção do termo Competência Digital a partir da promulgação da Base Nacional Comum Curricular (BNCC), seguindo a tendência internacional para o termo.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 15 по 21 июня 2024 г.
Authors: Дмитриева Людмила , Чумачкова Елена , Краснов Ярослав , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: June 2024

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 Omicron вызывающих интерес (VOI) и находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 15 по 21 июня 2024 г.
Multiscale observation product (MOP) for temporal flood inundation mapping of the 2015 Dallas Texas Flood
Authors: Sava Elena , Cervone Guido , Kalyanapu Alfred
Published: June 2024

This paper presents a new data fusion multiscale observation product (MOP) for flood emergencies. The MOP was created by integrating multiple sources of contributed open-source data with traditional spaceborne remote sensing imagery to provide a sequence of high spatial and temporal resolution flood inundation maps. The study focuses on the 2015 Memorial Day floods that caused up to US$61 million of damage. The Hydraulic Engineering Center River Analysis System (HEC-RAS) model was used to simulate water surfaces for the northern part of the Trinity River in Dallas, using reservoir surcharge releases and topographic data provided by the US Army Corps of Engineers. A measure of fit assessment is performed on the MOP flood maps with the HEC-RAS simulated flood inundation output to quantify spatial differences. Estimating possible flood inundation using individual datasets that vary spatially and temporally allow an understanding of how much each observational dataset contributes to the overall water estimation. Results show that water surfaces estimated by MOP are comparable with the simulated output for the duration of the flood event. Additionally, contributed data, such as Civil Air Patrol, although they may be geographically sparse, become an important data source when fused with other observation data.
Ischemic heart disease and cardiac arrhythmia are associated with increased cardiac aging
Authors: Salih Ahmed , Rauseo Elisa , Galazzo Ilaria , Pujadas Esmeralda Ruiz , Campello Victor , Lekadir Karim , Aung Nay , Slabaugh Greg , Dabbagh Ghaith , Chahal Anwar , Menegaz Gloria , Petersen Steffen
Published: June 2024

Ischemic heart disease (IHD) and cardiac arrhythmia (CA) patients experience alterations in cardiac structure and function which can speed up cardiac aging. Estimating biological heart age using cardiac magnetic resonance (CMR) and electrocardiogram (ECG)-derived phenotypes provides a biomarker for cardiac aging. We investigated the impact of IHD and CA on cardiac aging using biological age estimation biomarkers, and the role of age-related cardiac changes and vascular risk factors (VRF)s using data from United Kingdom Biobank. Cardiac age was estimated in prevalent IHD (n = 2,142) and CA (n = 1,683) subjects using a Bayesian ridge regression model with CMR radiomics and ECG features. Heart age gap (HAG), the difference between predicted and chronological heart age, was calculated. Mediation analysis explored CMR metrics as mediators in the HAG-cardiac disease association. The association of HAG and VRFs in each disease cohort was also analysed. IHD subjects had significantly increasing heart age (HAG: 1.55 years ± 5.66; p < 0.001), as did CA individuals (HAG: 1.57 years ± 5.77; p < 0.001). Conventional CMR metrics describing normal age-related changes partially mediated the effect of disease on HAG. High adiposity contributed most to increasing HAG in IHD, followed by hypertension. Hypertension had the greatest impact on cardiac aging, followed by high cholesterol in CA.
A preliminary study of calcite saturation states with varying pH and salinity
Authors: Heng Boaz Chung Yi , Joynson Jerry , Willis Steve , Khoiroh Ianatul , Koyande Apurav Krishna , Foo Dominic
Published: June 2024

The present work explores accelerated weathering of limestone (AWL) as an option to combat the climate change problem posed by the still growing carbon footprint. AWL is a promising low-technology solution that sequesters CO2 through the dissolution of calcium carbonate (CaCO3) in water to form calcium bicarbonate. One aspect of the feasibility of its application is whether the newly formed bicarbonate will remain in solution for the long term. This paper examines the carbonate equilibria for various water bodies by combining Bjerrum plots with the calcite saturation value, omega. The hydrochemistry software, aqion, was used to simulate a range of water compositions with different salinities at various conditions. The study compares saturation states of rainwater, limestone quarry water, seawater, and reverse osmosis concentrate, with their respective dissolved inorganic carbon (DIC) concentrations, across the full range of pH values. The areas of stability and instability can be observed from the generated plots in order to be able to design effective AWL processes. A key issue for successful implementation of AWL is operating within the CaCO3 saturation limit and ensuring dissolved material does not subsequently reprecipitate.
Predicting Exploration Crew Medical Officer Training Needs
Applying Evidence Based Predictive Analytics to Space Medicine Training
Authors: Levin Dana , McIntyre Lauren , Steller Jon , Nelson Ariana , Zahner Chris , Anderson Arian , Parmar Prashant , Hilmers David
Published: June 2024

Predictive analytics may be a useful adjunct to identify training needs for exploration class medical officers onboard deep space vehicles.

This study used a preliminary version of NASA’s newest medical predictive analytics tool, the Medical Extensible Database Probabilistic Risk Assessment Tool (MEDPRAT), to test the application of predictive analytics to Exploration Crew Medical Officer (exploration CMO) curriculum design for 5 distinct mission profiles. Curriculum elements were identified using a leave-one-out analysis and a threshold of 5% risk increase over the fully treated baseline.

This proof-of-concept study demonstrated that predictive analytics can rapidly generate generic and mission profile specific exploration CMO curricula using an evidence-based process driven by optimizing mission risk reduction. This technique may serve as part of a human-machine team approach to medical curriculum planning for future space missions. It has significant potential to improve astronaut health and save time and effort for both planners and trainees.
Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of SLC26A4 c.919–2A>G Variant
Authors: Wu Chen-Chi , Chan Yen-Hui , Ho Chang-Han , Tsai Cheng-Yu , Chang Chi-Chieh , Hu Chin-Ju , Lu Ying-Chang , Lin Pei-Hsuan , Cheng Yen-fu , Lin Chin-Hsien , Lin Han-I , OuYang Chih-Hsin , Hsu Chuan-Jen , Liu Tien-Chen , Chen You-Tzung , Huang Cheng-Yen
Published: June 2024

Recessive variants of SLC26A4 are a common cause of hereditary hearing impairment and are responsible for non-syndromic enlarged vestibular aqueducts and Pendred syndrome. Patients with bi-allelic SLC26A4 variants often suffer from fluctuating hearing loss and recurrent vertigo, ultimately leading to severe to profound hearing impairment. However, there are currently no satisfactory prevention or treatment options for this condition. The CRISPR/Cas9 genome-editing technique is a well-known tool for correcting point mutations or manipulating genes and shows potential therapeutic application for hereditary disorders. In this study, we attempted to use the homology-independent targeted integration (HITI) strategy to correct the SLC26A4 c.919-2A > G variant, the most common SLC26A4 variant in the Han Chinese population. Next-generation sequencing was performed to evaluate the editing efficiency of the HITI strategy. The results showed that only 0.15% of the reads successfully exhibited HITI integration, indicating that the c.919-2 region may not be a suitable region for HITI selection and that other site selection or insertion strategies may be needed to improve the efficiency of correcting the SLC26A4 c.919-2A > G variant. This experience may serve as a valuable reference for other researchers considering CRISPR target design in this region.
Impact of Vitamin D Suplementation in Clinical Outcome at Tuberculosis Spondylitis : Randomized Controlled Trial
Authors: Arifin Jainal , Massi Muhammad Nasrum , Biakto Karya Triko , Bukhari Agussalim , Usman Muhammad Andry , Hamid Firdaus , Adnan Endy , Johan Muhammad Phetrus , Zainuddin Andi Alfian
Published: June 2024

Mycobacterium tuberculosis (MTB) causes infectious bacterial disease. Most cases of musculoskeletal tuberculosis affect vertebrae which cause spinal tuberculosis (spondylitis), extrapulmonary tuberculosis. Vitamin D deficiency have higher risk in tuberculosis infection. Vitamin D had role in the activation processes on immune cell which eliminate tuberculosis infection. The aim of the study is to assess the impact of oral supplementation of serum vitamin D on clinical outcome in spinal tuberculosis. The study design is randomized controlled trial. Total partisipants is 36 samples. The inclusion criteria were spinal tuberculosis patients diagnosed with MRI and GenExpert. The exclusion criteria were pulmonary tuberculosis, partisipant with other chronic disease such as diabetes, autoimun, malabsorption syndrome. Vitamin D serum levels were measured by ELISA method. There is a significant increasing serum levels of vitamin D in the study group were observed after 4 and 8 supplementation (p< 0.05). On the assessment of ODI and VAS, it decrease significantly in the three groups after 8 weeks of vitamin D supplementation (p<0.05), but in group 10.000 IU also decrease ODI and VAS score significant after 4 weeks supplementation.
Trial Registration
This study had clinical trial approved by U.S National Library of Medicine (NCT05376189, May 17, 2022).
Objective evaluation of skin stiffness in breast cancer-related lymphedema using MyotoPRO
Authors: Mitsuoka Hiroki , Arima Takahiro , Ito Yukie , Fujii Kimihito , Otsuka Shun , Shan Xiyao , Shima Miki , Takagi Kensuke , Osawa Mitsuharu , Naito Munekazu , Nakano Shogo , Kodama Akio
Published: June 2024

Purpose
Severe lymphedema leads to a decline in quality of life. Skin stiffness is one of the symptoms of lymphedema; however, no objective method has been established to evaluate this symptom. We aimed to examine whether MyotonPRO, which is used to evaluate muscle and fascia stiffness, could evaluate skin stiffness in upper limb lymphedema.
Methods
Female patients with breast cancer-related lymphedema (BCRL) after unilateral breast cancer surgery were included. Stiffness by MyotonPRO and circumference were measured on both sides 5 and 10 cm from the elbow joint of the forearm and upper arm, respectively. Measurements were compared between the normal and lymphedema limbs. History of breast cancer, lymphedema and comorbidities were collected from medical records, and the relationship with skin stiffness was evaluated.
Results
The skin stiffness values of normal and lymphedema limbs were 249 ± 50 and 283 ± 56 N/m (p < 0.001) in the upper arm and 306 ± 44 and 353 ± 64 N/m (p < 0.001) in the forearm, respectively, and were significantly greater in the lymphedema limb. The circumferences of the normal and lymphedema limbs were 27.5 ± 3.6 and 29.1 ± 4.0 cm (p < 0.001) for the upper arm and 23.7 ± 2.4 and 25.1 ± 2.9 cm (p < 0.001) for the forearm, respectively, in which the lymphedema limb was significantly larger. In the multiple regression analysis, diabetes had the greatest effect on the lymphedema limb stiffness.
Conclusion
MyotonPRO can objectively assess chronic skin stiffness in BCRL.
Genotypic and Physiological Evaluation of Mungbean (Vigna radiata) for Yield and Heat Tolerance
Authors: Mudasir Muhammad , Bashir Sadia
Published: June 2024

Heat stress due to climate change could be a critical factor for plant growth as it disturbs flowering time and reduces the crop yield. Therefore, it is crucial to investigate the performance of crop genotypes under heat stress condition. The present research was conducted to assess heat tolerance in 25 mungbean genotypes. The experiment was performed in randomized complete block design on two sowing dates: normal sowing (39°C/26°C) and late sowing for heat treatment (47°C/30°C). All genotypes showed significant variations for treatments, genotypes, and genotypic × treatment interactions. Significantly positive correlation of plant height (0.73**, 0.44**), number of seeds per pod (0.74**, 0.45**) and 100-seed weight (0.89**, 0.43**) with seed yield was recorded under both control and stress conditions, respectively. Principal component analysis revealed a high contribution of seed yield, yield index, geometric mean productivity, tolerance, stress tolerance index and mean productivity for PC1 and PC2. Cluster analysis revealed that genotypes retained in cluster 1 and 2 could be utilized to combine yield and stress stability indices in breeding programs. Findings from multivariate analysis suggested that MN-98, MN-108, MN-2011, MN-2225, MN-93 and MN-203 are potential cultivars under heat stress. Hence, these genotypes could be used as genetic resources for transferring heat tolerance to elite genotypes that are sensitive to high temperatures.
Research on the Regional Disparities and Temporal-Spatial Convergence of the Carbon Emission Reduction Maturity in China
Authors: Yi WANG , Shuo FAN
Published: June 2024

To reveal the spatial evolution, regional inequality and convergence characteristics of carbon emission reduction maturity in China, the paper calculates the maturities of carbon emission reduction of 30 provinces from 2006 to 2021, and describes the spatial pattern of its average level by using of Arcgis technique. The Dagum Gini coefficient is used to reveal the regional inequality and its source, and the convergence is empirically tested by σ convergence and β convergence. The research results show that the carbon emission reduction maturity has an overall improvement trend in China, but it has obvious non-equilibrium characteristics. The regional disparities are the main sources of the non-equilibrium which the carbon emission reduction maturity had. The carbon emission reduction maturity in the eastern region has σ convergence, while the carbon emission reduction maturities in other regions show divergence. The carbon emission reduction maturity in China shows obvious temporal-spatio β convergence characteristics, and the maturities of carbon emission reduction in eastern and western regions are similar to the country, while northeast and central regions’ are completely opposite. Finally, in order to improve the carbon emission reduction maturities and effectively narrow the regional inequality, the paper puts forward policy suggestions from three aspects: high-quality development, scientific and technological innovation and complementary integration.