bluuebunny/crossref_metadata_2025 huggingface dataset:
What Makes North Kalimantan Residents Take Housing Loans?
Authors: Budianto Oky Prasetya
Published: June 2023

Housing is one of the human needs that must be met. Many ways are used to get the required residence (house). One of them is by taking a housing loan. Various factors can become obstacles in taking housing loans. This study used logistic regression – Logit and took a sample of 514 households in North Kalimantan Province. This research will examine the influence of economic, social, demographic, and geographic factors in household decisions to take housing loans. The results showed that household income, interest rates, HOH employment status, HOH age, and household location had a significant positive effect. In contrast, income per capita and marital status had a significant negative effect. Meanwhile, the number of HM working had no significant effect. Of the variables used, the household location variable influences a household’s decision to take housing loans with an OR of 3.62.
Reduced graphene oxide reinforced PDA-Gly-PVA composite hydrogel as strain sensors for monitoring human motion
Authors: Ke Xiaoling , Mu Xiaojiang , Chen Siyi , Zhang Zhixiang , Zhou Jianhua , Chen Yulian , Gao Jie , Liu Jing , Wang Xiaoyang , Ma Chuanguo , Miao Lei
Published: June 2023

Hydrogels with soft, skin-friendly properties and high biocompatibility are promising alternatives to traditional sensors. However, balancing electrical conductivity and sensitivity remains a significant challenge. The sensitivity-improved strain sensor was designed by reduced graphene oxide (rGO) reinforced polydopamine (PDA)-glycerol (Gly)-polyvinyl alcohol composite hydrogels (PGPHs). The hydrogels exhibited excellent sensing sensitivity with a gauge factor of 2.78, conductivity of 2.2 S/m, tensile deformation of 200%, fast response time of 370 ms, and recovery time of 260 ms, surpassing those of most previously reported hydrogel-based strain sensors. This improvement can be attributed to the high electrical conductivity and uniform distribution of the rGO associated with Gly and PDA. PGPHs also exhibited an attractive monitoring effect for hand movements and precise detection feedback for the slight dynamics of the pharynx. Hydrogel-based strain sensors have been demonstrated as a potentially sustainable solution for dynamic detection and communication.
Research on Abnormal Feature Extraction and Early Fault Alarm Method of Rolling Bearing's Based on CDAE and KLD
Authors: Qin Zheng , Chang Qin , Li Qiang , Wang Yao , Wang Jie , Xu Weiwei
Published: June 2023

A rolling bearing is an important part of rotating machinery, and it is widely used in the petrochemical industry, aerospace industry and other industries. Hence, it is of great significance to carry out condition monitoring and fault alarms for rolling bearings. Aiming at the problem of the rolling bearing fault, a method of an improved deep convolutional denoising auto encoder abnormal feature extraction and the Kullback-Leibler divergence threshold alarm is proposed. The experiment verification is carried out on the rotor bearing experiment platform. The experiment results show that the proposed method has good denoising performance and micro fault feature extraction ability under the condition of no fault data training and no frequency domain transformation. High accuracy, good efficiency and strong robustness of the proposed method for an early fault alarm are demonstrated by the experiment as well.
Research on Transformer Voiceprint Feature Extraction Oriented to Complex Noise Environment
Authors: Xiang Shen , Fei Xu , Long Xu , Jidong Cai
Published: June 2023

Transformer fault diagnosis based on acoustic characteristics is a new non-contact and non-destructive monitoring method. It has the advantages that the acoustic signal detection is not disturbed by electric and magnetic fields, and the monitoring process does not affect the normal operation of the transformer. Aiming at the difficulty of extracting transformer voiceprint features in complex noise environment, a transformer voiceprint feature extraction method based on Variable Mode Extraction (VME) is proposed. In this method, the center frequency of the Intrinsic Mode Function(IMF) is set according to the generation mechanism of transformer radiated noise, thus the uncertainty of decomposition results caused by random distribution and other frequency search methods is eliminated; Then, taking the frequency-domain energy aggregation of IMF and the minimum center frequency energy of residual signal as the optimization objectives, the cyclic iterative decomposition is used to identify and extract the transformer voiceprint features, so as to reduce the impact of environmental noise and other equipment noise. The analysis results of simulation signals and field signals show that this method can effectively reduce the impact of environmental noise and extract more clear and accurate transformer voiceprint features.
An operational model for capturing grape ripening dynamics to support harvest decisions
Authors: Van Leeuwen Cornelis , Destrac-Irvine Agnès , Gowdy Mark , Farris Laura , Pieri Philippe , Marolleau Laura , Gambetta Gregory A.
Published: June 2023

Grape ripening is a critical phenological phase during which many metabolites that impact wine quality accumulate in the berries. Major changes in berry composition include a rapid increase in sugar and a decrease in malic acid content and concentration. Its duration is highly variable depending on grapevine variety, climatic parameters, soil type and management practices. Together with the timing of mid-veraison, this duration determines when grapes can be harvested.Viticulturists and winemakers monitor the sugar-to-total acidity ratio (S/TA) during grape ripening and start harvesting grapes when this ratio reaches the optimum value for the desired wine style. The S/TA ratio evolves linearly as a function of thermal summation during the first four weeks following the onset of ripening. The linearity of the evolution of the S/TA ratio as a function of thermal time during the first four weeks following mid-veraison is applied in this study on two large data sets encompassing (1) 53 varieties studied during 10 years with two to four replicates for each combination of year and cultivar and (2) two varieties, cultivated on three soil types over 13 years. Grape ripening speed is highly variable. The effects of the year impact ripening speed more than the effects of the soil or the variety, although all three effects are highly significant. Grape ripening speed decreases with berry weight and also varies with vine water status. By using this approach, viticulturists and winemakers can assess four weeks after mid-veraison, for each individual vineyard parcel, at what speed grape ripening progresses. Combined with precise mid-veraison scoring, expertise from previous vintages and complementary approaches like sensory assessment of berries, it allows harvest date estimates to be fine-tuned. The results of this study can also be used to identify slow ripening varies, which are better performing in warm climates and, thus, better adapted to climate change.
Authors: Ropiudin Ropiudin -
Published: June 2023

Biobriket merupaka bahan bakar alternatif yang berwujud padat dan berasal dari limbah atau sisa-sisa bahan organik yang telah mengalami proses pemampatan dengan tekanan tertentu. Biobriket ini merupakan biobriket campuran tempurung kelapa dan sekam padi dengan variasi perekat serta variasi ukuran serbuk. Tujuan dari penelitian ini adalah untuk mengetahui kadar perekat tepung tapioka yang optimal dalam proses pembuatan biobriket dari tempurung kalapa dan sekam padi, mengetahui pengaruh ukuran serbuk terhadap kualitas biobriket yang dihasilkan dan mengetahui kombinasi terbaik antara kadar perekat dan ukuran serbuk untuk menghasilkan biobriket. Pembuatan biobriket menggunakan 30, 40 dan 50% perekat dengan ukuran serbuk sebesar 20, 40, 60 mesh. Metode rancangan percobaan dilakukan dengan Rancangan Acak Lengkap atau RAL dengan 2 faktor yaitu variasi perekat dan variasi ukuran serbuk. Analisis data dilakukan dengan uji ANOVA dan dilanjut dengan DMRT. Hasil yang didapat yaitu, variasi perekat memberikan pengaruh tidak nyata laju pembakaran, sedangkan ukuran serbuk memberikan pengaruh tidak nyata terhadap kadar air. Kadar Air yang didapat sekitar (3,2-6%) sudah memenuhi SNI, sedangkan kerapatan yang tidak memenuhi SNI yaitu biobriket dengan ukuran serbuk 20 mesh.
Authors: Bela Gesit Marti , Suhardi Imam , Yanti Sri Nani Hari
Published: June 2023

Penelitian ini membahas cerpen Siapa Namamu, Sandra? karya Norman Erikson Pasaribu yang mengisahkan tentang perjalanan seorang ibu yang mengalami kedukaan sesudah kematian anak tunggalnya. Cerpen tersebut memuat psikologis tokoh utama dan suasana atmosferik, tempat, atau objek. Berdasarkan hal tersebut, penelitian ini difokuskan untuk mengidentifikasi leksia-leksia yang dikategorikan sebagai kode semik dalam kajian semiotika Roland Barthes. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Teknik pengumpulan data yang digunakan adalah teknik baca dan catat. Teknik analisis data yang digunakan adalah teknik analisis isi atau konten. Hasil penelitian menemukan 14 leksia kode semik. Adapun pemaknaan leksia-leksia tersebut menghasilkan 3 makna yang diperoleh dengan bantuan teori Psikoanalisis Jacques Lacan. Tiga makna tersebut yaitu kebahagiaan sebagai permintaan (demand), nama sebagai identitas, dan kehilangan. Makna-makna yang diperoleh menggambarkan fase ketidakutuhan dalam diri tokoh utama. Oleh karena itu, cerpen Siapa Namamu, Sandra? dapat dijadikan sebagai pembelajaran.

Kata kunci: semiotika, kode semik, leksia, makna
Authors: Fitri Maria Magdalena
Published: June 2023

Novel Dangerous Nerd ini merupakan hasil karya dari Siska Febrianty. Novel ini menceritakan tentang seorang anak yang orang tuanya telah dibunuh oleh seseorang dan harus dipecahkan masalahnya. Novel ini penuh dengan misteri dan teka teki. Oleh karena itu, gadis ini datang ke kota untuk membalaskan dendam kedua orang tuanya serta memberantas rantai pembunuhan yang terjadi pada masa lalu. Adapun tujuan dari penelitian ini yaitu, agar novel ini lebih dikenal di kalangan masyarakat luas serta menjadi sumber ilmu baru bagi masyarakat. Jenis penelitian ini adalah kualitatif dengan menggunakan sumber data yaitu novel Dangerous Nerd. Teknik pengumpulan datanya dengan studi pustaka dan teknik analisis datanya menggunakan metode deskriptif. Hasil penelitian ini adalah menunjukkan tema, alur/plot, tokoh dan penokohan, sudut pandang, gaya bahasa, serta amanat.
Authors: Manikandini Azizah , Wahyudi Agus Budi
Published: June 2023

Perkembangan bahasa di jejaring sosial melahirkan banyak bentuk yang menarik untuk dikaji. Tujuan penelitian ini ialah untuk mendeskripsikan proses fonemik yang terjadi di jejaring sosial twitter. Penelitian yang merupakan jenis kualitatif ini menggunakan metode penelitian padan dan agih. Hasilnya, terdapat 8 proses fonemik yang terjadi di jejaring sosial twitter berupa zeronisasi (lima aferesis, empat sinkop, tiga apokop), empat metatesis, anaptiksis (dua protesis, tiga epentesis, lima paragog), dan empat netralisasi. Penulis cenderung menghilangkan fonem vokal /a/, /i/, dan /e/ sementara fonem vokal /u/ dan /o/ tidak banyak muncul, penambahan fonem terjadi pada fonem vokal /a/, ataupun fonem konsonan yang menjadi fonem akhir dalam sebuah kata.
Estetika Cerpen Ahmad Tohari Dari Sudut Pandang Publik Seni
Authors: Setyaningrum Sri Nurhayati , Rahayu Selvia Era , Putri Evani Asiya Kusuma , Puspitasari Rini
Published: June 2023

Cerita pendek merupakan karya sastra berupa prosa yang umumnya bercerita tentang hal nyata maupun fiksi. Tujuan penelitian ini ialah menganalisis unsur estetika dalam publik seni. Beberapa unsur yang dianalisis di antaranya interpretasi, apresiasi, isi, bentuk, gaya bahasa, dan evaluasi pada cerpen. Metode yang digunakan dalam penelitian ini ialah deskriptif kualitatif. Metode deskriptif diartikan sebagai prosedur pemecahan masalah yang diselidiki dengan menggambarkan atau melukiskan keadaan subjek atau objek penelitian (novel, drama, cerita pendek, dan puisi) berdasarkan fakta yang tampak dan sebagaimana adanya. Sedangkan metode kualitatif dimaksudkan penyampaian makna dari isi karya tersebut.  Hasil penelitian dapat memunculkan analisis seni yang dilakukan oleh pembaca/publik seni sehingga dapat memunculkan nilai-nilai sosial yang dapat diwujudkan dalam bentuk empati maupun simpati atau hal positif lainnya.
Pengaruh Pemberian Vitamin E Terhadap Derajat Stress Oksidatif Akibat Olahraga
Authors: Ngadiman Ngadiman , Noor Heza Fuad , Suko Wahono Bayu
Published: June 2023

Olahraga mempunyai dampak positif dan negatif. Dampak positif olahraga diantaranya adalah meningkatkan kebugaran dan kesehatan, meningkatkan prestasi dan mencegah berbagai penyakit. Salah satu dampak negatif olahraga adalah terbentuknya senyawa oksidan yang memicu peristiwa stres oksidatif. Stres oksidatif terjadi karena sistem pertahanan antioksidan tubuh tidak mampu mengimbangi produksi radikal bebas. Stress Oxidative (SOD) dan Malondialdehyde (MDA) merupakan penanda aktivitas biologis dalam organisme yang terpapar stres oksidatif dari radikal bebas. Vitamin E adalah contoh antioksidan eksogen yang memiliki kandungan berbagai komponen antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian vitamin E sebelum aktivitas fisik terhadap konsentrasi malondialdehida plasma dan derajat kerusakan SOD akibat stres oksidatif pada manusia setelah aktivitas fisik. Rancangan penelitian menggunakan desain kelompok kontrol uji coba pasca laboratorium dengan tiga kelompok yang masing-masing terdiri dari sembilan subjek. Pengukuran dilakukan dengan mengambil 3 cm3 darah sebelum dan sesudah aktivitas fisik submaksimal. Dari uji post hoc diketahui terdapat perbedaan yang bermakna (0,001) antara kelompok kontrol dan kelompok K1 (dosis vitamin E 250 mg). Terdapat perbedaan bermakna (0,000) antara kelompok kontrol dan kelompok K2 (vitamin E dosis 500mg). Terdapat perbedaan bermakna (0,006) antara kelompok perlakuan K1 (vitamin E dosis 250mg) dengan K2 (vitamin E dosis 500mg). Simpulan dari penelitian ini adalah pemberian antioksidan eksogen (vitamin E dosis 250 mg dan dosis 500 mg) sebelum aktivitas fisik  selama tujuh hari dapat menurunkan kadar SOD dan MDA plasma
Pempek: Traditional fishcake dish from South Sumatra, Indonesia
Authors: Surya Reggie , Destifen Welsen , Nugroho David , Stephanie
Published: June 2023

Pempek is a traditional fishcake dish from South Sumatra, Indonesia. Its primary ingredients are narrow-barred Spanish mackerel (Scomberomorus commerson) and sago starch. As a dish, Pempek is usually served with a sweet and sour sauce called kuah cuko, containing palm sugar, vinegar, tamarind, and chili pepper. Historically, Pempek is highly influenced by Chinese cuisine.Pempek exists in different varieties, most of which are widely known and available in many Indonesian cities. The variation among different types of Pempek appears due to different additional ingredient, shape, filling, cooking method, and serving style. Some well-known types of Pempek include Pempek adaan (round shaped), Pempek lenjer (cylindrical shaped), Pempek kapal selam (egg stuffed), Pempek keriting (curly shaped), and Pempek kulit (made with fish skin). New innovations on Pempek recipe are also thriving owing to people’s creativity. The popularity of Pempek has made this dish the symbol of identity and pride for the people of South Sumatra. It is also rich in historical and philosophical values that represent the South Sumatran traditional way of life. In addition, Pempek is currently considered to be an Intangible Cultural Heritage by the UNESCO. This review discusses the history, traditional production process, philosophy, nutritional aspects, and different varieties of Pempek.
Seasonal changes in the ratio of congeneric charrs in northern Japanese tributaries with different temperature regimes
Authors: Yamada Taihei , Koizumi Itsuro , Nakamura Futoshi
Published: June 2023

Background: The species distributions and community compositions of stream fishes are often shaped by water temperature. Stream salmonids, for example, show longitudinal gradients or marked community differences between spring-fed vs. non-spring-fed streams, which may be a result of species-specific temperature preferences, interspecific competition, or their interaction (i.e., temperature-dependent competition). Despite the widely reported patterns, how such temperature-associated distributions change across seasons remains largely unknown. If temperature is the main driver, the pattern will change across seasons. Alternatively, seasonal patterns will be obscured if other factors, such as species-specific life histories or seasonal aggregation, are important. Here, we investigated the effects of water temperature on the abundance and species ratio of two potentially competing salmonids, southern Asian Dolly Varden Salvelinus curilus and white-spotted charr Salvelinus leucomaenis, in 6 small tributaries with different temperature regimes (i.e., spring-fed and non-spring-fed) across seasons.
Results: Across seasons, the southern Asian Dolly Varden dominated in spring-fed tributaries, whereas white-spotted charr dominated in non-spring-fed tributaries. The seasonal variation in the abundance of southern Asian Dolly Varden and species ratio were explained by water temperature fluctuation, whereas that of white-spotted charr was not explained by the temperature fluctuation. No winter aggregation was observed in any of the tributaries. In addition, only the species ratio in summer was explained by the water temperature, and the water temperature did not fully explain the species ratio.
Conclusions: Our results indicated that temperature preference and/or the strength of interspecific competition may differ across seasons, which is expected to determine the seasonal distribution patterns in spring-fed and non-spring-fed tributaries. This study underscores the importance of considering seasons when evaluating temperature effects on the distribution of stream salmonids.
SuRxgWell: Study Protocol for a Randomized Controlled Trial of Telemedicine-based digital Cognitive Behavioral Intervention for high Anxiety and Depression Among Patients Undergoing Elective Hip and Knee Replacement surgery
Authors: Kaynar Ata Murat , Lin Charles , Sanchez Andrea Gomez , Lavage Daniel R. , Monroe Amy , Zharichenko Nicole , Strassburger Meredith , Saucier Katheryn , Groff Yram J. , Klatt Brian A , O'Malley Michael J. , Szigethy Eva M. , Wasan Ajay D. , Chelly Jacques E
Published: June 2023

Background
Mood disorders (anxiety, depression) and catastrophizing, lead to increased post-operative pain perception, decreased engagement with physical activity, and increased resource utilization. Studies on perioperative psychological assessment and treatment are scarce. Digital cognitive behavioral intervention (dCBI) such as RxWelläreduces depression in patients with inflammatory bowel disease. We hypothesize that SuRxgWell, the surgical adaptation of RxWellä, can improve preoperative mood disorders and subsequently reduce postoperative pain and opioid requirement in patients undergoing primary total hip and knee arthroplasty (THA, TKA).
Methods
This randomized, controlled trial will enroll primary and unilateral THA or TKA patients with anxiety and/or depression symptoms before surgery to receive the SuRxgWell. After an informed consent, subjects will be screened using the PROMIS Anxiety/Depression questionnaires. Subjects with a T-score of ≥ 60 will be randomized to either usual care (control group) or SuRxgWell dCBI pre- and perioperative cognitive behavioral intervention via RxWell plus usual care (intervention group). Control group will receive information on how to locate tools to address mood disorders, whereas the intervention group will have access to SuRxgWell 1 month prior to surgery and up to 3 months thereafter. The allocation will be 3:1 (intervention: control). Investigators will be blinded, but research coordinators and subjects will not.
The primary outcome will be day of surgery anxiety or depression symptoms measured with the PROMIS Anxiety/Depression, GAD-7, and PHQ-8. Secondary endpoints include sleep disturbance, fatigue, ability to participate in social roles, pain interference, cognitive function, pain catastrophizing, and physical function as well as preoperative and postoperative pain scores, pain medication usage, orthopedic functional recovery at baseline, day of surgery, and 1, 2, and 3 months after the surgery. Subjects will complete a GAD-7 and PHQ-8 questionnaires bi-weekly. Data about RxWell usage and engagement, postsurgical complications, and resource utilization will be recorded. The primary outcome will be analyzed with intention-to-treat estimates and tested using independent two sample t-tests.
Discussion
We will evaluate dCBI as a perioperative tool to improve anxiety and depression before and after major orthopedic surgery. If effective, this might have important clinical implications towards improving outcomes.
Trial Registration
clinicaltrials.gov, NCT05658796. Registered 21 December 2022. https://clinicaltrials.gov/ct2/show/NCT05658796
Blood-conserving and therapeutic efficacy of intravenous tranexamic acid at different time points in primary total knee arthroplasty with tourniquet application: a randomized controlled trial
Authors: Wang Mingyou , Lan Yuping , Wang Hongping , Chen Chunyu , Mei Zhu , Tao Qifeng
Published: June 2023

Objective
To investigate the effect of the first dose of tranexamic acid received intravenously before tourniquet compression and release in total knee arthroplasty (TKA) on perioperative blood loss and therapeutic efficacy of patients.
Methods
In this double-blind trial, 90 patients undergoing primary TKA were randomized into 2 groups: the patients in group A was received intravenous tranexamic acid (TXA) 10 minutes before tourniquet compression (20 mg/kg) and 3, 6 and 24 hours later (10 mg/kg), and the patients in Group B was treated the same as Group A but received intravenous TXA before tourniquet release. The primary outcomes were the change of blood loss, hemoglobin and hematocrit. Secondary outcomes included operation and tourniquet time, blood transfusion rate, subcutaneous petechiae and circumferential changes of the operated limb, visual analog scale (VAS), hospital for special surgery (HSS) score, length of stay (LOS) postoperatively, complications and patient satisfaction.
Results
No statistically significant differences were found between the 2 groups with regard to age, gender, weight, BMI, Kellgren-Lawrence class, preoperative blood volume, preoperative laboratory values, operation and tourniquet time, transfusion rate, knee circumference, preoperative HSS, VAS. There was no significant difference in intraoperative blood loss (IBL) (52.71 ml vs. 63.44 ml, P= 0.07), hidden blood loss (HBL) (91.39 ml vs. 119.90, P= 0.40) and total blood loss (TBL) (144.1 ml vs. 183.3 ml, P= 0.72) between groups A and B. Hemoglobin, hematocrit and red blood cell count (RBC) dropped to a low point on postoperative day 3 and then rebounded, returning to normal levels on day 21, and the trend of change between the 2 groups was no statistically significant difference. There was no significant difference in subcutaneous ecchymosis, knee swelling, HSS, VAS, LOS postoperatively, complication rate and patient satisfaction.
Conclusion
There was no significant difference in total perioperative blood loss, knee swelling, subcutaneous bruising and petechiae, knee function, complication rate and satisfaction between the intravenous tranexamic acid before tourniquet compression and release in primary total knee arthroplasty. However, the trend towards better reduction of perioperative blood loss, as reflected by changes in blood loss and h ematocrit, may be related to the role of the effective blood concentration formed in the operative area before tourniquet pressurization. Although it is not possible to conclude that better hemostasis can be achieved by administration before tourniquet compression, we believes that 10 minutes before tourniquet compression is a more recommendable option when conditions permit, and that the second postoperative dose should be dripped intravenously 3 hours after the first dose to ensure effective plasma concentrations.
Monitoring of electricity generation from exhaust waste heat and wireless data recording from a mobile phone in real driving conditions of a vehicle
Authors: Akal Dinçer , umut ilhan
Published: June 2023

This study is aimed to design electrical energy production and wireless data monitoring system by utilizing the working principles of thermoelectric generators from the exhaust waste heat of vehicles in traffic. In order to transmit the heat transfer in the exhaust pipe to the thermoelectric generators, a modular system has been developed in a hexagonal form that can be dismounted and mounted from aluminum material. Six thermoelectric generators (TEG-SP1848) are used on the aluminum module, and a heat sink is used to cool each thermoelectric generator. The voltage and current values of the electrical energy produced from the exhaust waste heat of the vehicle in real driving conditions are recorded with a special program written on the card on the system. Depending on the results obtained from the test drives, electrical energy was obtained at a maximum voltage of 9.8 V and a current of 0.32 A. This electrical energy obtained from the exhaust waste heat can be stored in the vehicle's existing battery if desired. In this way, since the alternator used for the electricity generation of the vehicle will be activated less, some fuel savings will be achieved in the engine, and harmful exhaust emissions will be reduced. In addition, the electrical energy obtained by this method can be stored in an external battery independent of the vehicle battery and used for various purposes when the vehicle is at a standstill or with a portable battery.
Expression of long non coding RNA H19& miR-675 in colorectal cancer and ulcerative colitis patients
Authors: Sobhy Rania , Shaker Olfat , Khairy Ahmed , Gaber Dalia A.
Published: June 2023

Background: Colorectal cancer (CRC) is a growing public health problem and has been stretching in the recent years from old age group to encompass younger age group. Inflammatory bowel disease like ulcerative colitis is a risk factor for CRC.
Aim: Test the expression of microRNA- 675 (miR-675) and long non coding RNA H19 (Lnc H19) for their diagnostic & prognostic potential in CRC.
Methodology: A prospective cross-sectional study was conducted on 60 patients with CRC, 60 patients with UC as well as 30 control subjects. miR-675 & lnc H19 were quantified by real time RT-PCR. Lab investigations and radiological investigations were also performed and correlated with the genetic biomarkers.
Results: Lnc H19 was highly expressed in both CRC and UC groups with a statistically significant difference from the control group. There was a significant enhanced expression of H19 in CRC compared to UC group. Although miRNA -675 was down regulated in both UC and CRC groups but it was more expressed in CRC compared to UC group.
Conclusion: According to our results we can conclude that H19 can be considered as potential non-invasive biomarker for diagnosis of UC and early detection of CRC
ERASURE: Early autologous blood pleurodesis for postoperative air leaks - A randomized, controlled trial comparing prophylactic autologous blood pleurodesis versus standard watch and wait treatment for postoperative air leaks following thoracoscopic (VATS) anatomic lung resections.
Authors: Karampinis Ioannis , Ruckes Christian , Doerr Fabian , Boeluekbas Servet , Ricciardi Sara , Cardillo Giuseppe , Galvez Carlos , Vidmar Bogdan , Stupnik Tomaz , Fang Vincent , Petersen Rene Horsleben , Roessner Eric Dominic
Published: June 2023

• Background: The prolonged air leak is probably the most common complication following lung resections. Around 10-20% of the patients that undergo a lung resection will eventually develop a prolonged air leak. The definition of a prolonged air leak varies between an air leak, which is evident after the fifth, seven or even tenth postoperative day to every air leak that prolongs the hospital stay. However, the postoperative hospital stay following a thoracoscopic lobectomy can be as short as two days, making the above definitions sound outdated. The treatment of these air leaks is also very versatile. One of the broadly accepted treatment options is the autologous blood pleurodesis or “blood patch”. The purpose of this trial is to investigate the impact of a prophylactic autologous blood pleurodesis on reducing the duration of the postoperative air leak and therefore prevent the air leak from becoming prolonged.
• Methods: Patients undergoing an elective thoracoscopic anatomic lung resection for primary lung cancer or metastatic disease will be eligible for recruitment. Patients with an air leak of > 100ml/min within 6 hours prior to the morning round on the second postoperative day will be eligible for inclusion in the study and randomization. Patients will be randomized to either blood pleurodesis or watchful waiting. Primary endpoint is the time to drain removal measured in full days. The trial ends on the seventh postoperative day.
• Discussion: The early autologous blood pleurodesis could lead to a faster cessation of the air leak and therefore to a faster removal of the drain. A faster removal of the drain would relieve the patient from all the well-known drain associated complications (longer hospital stay, stronger postoperative pain, risk of drain-associated infection etc.). From the economical point of view, faster drain removal would reduce the hospital costs as well as the costs associated with the care of a patient with a chest drain on an outpatient setting.
Trial registration: The study has been prospectively registered in the German Clinical Trials Register (DRKS, DRKS-ID: DRKS00030810)
Vascular Wall Vibrations in Arteriovenous Fistula; A Specific Stimulus for Stenosis Development and AVF Failure?
Authors: Bozzetto michela , Remuzzi Andrea , Valen-sendstad kristian
Published: June 2023

Hemodialysis is the lifeline for nearly three million end stage renal disease patients worldwide. Native arteriovenous fistula (AVF) is the preferred vascular access, but 40% fail within 1 year. We recently demonstrated that AVFs harbour transitional flows and the goal of the present study was to investigate whether the associated high-frequency pressure fluctuations could promote vibrations within the vascular wall. We acquired MRI images and flow rates immediately after surgery in one patient and generated a 3D patient-specific model. High-fidelity fluid structure interaction simulations revealed the presence of wall vibrations in distinct frequency bands up to 200 Hz and amplitude of 200 microns. A sensitivity analysis to assess the impact of flow rates, and vascular wall stiffness and thickness, changes that typically occur during AVF maturation, confirmed the robustness of the results. Interestingly, the vibrations were always predominant at the anastomosis floor and on the inner venous side, which correlates with typical stenotic regions. As studies seeking to correlate aberrant stresses and vascular remodelling have been largely inconclusive, the focal collocation between vibrations and stenosis may suggest an unknown mechanobiological process between high-frequency mechanical stresses within the vascular wall and adverse vascular remodelling.
Disulfidptosis-related NCK associated protein 1 as a potential biomarker for multiple tumor types: A pan-cancer analysis based on public databases
Authors: Cao Qian , Hong Aonan , Shen Ruizhi , Wang Chunhui , Liang Xiao
Published: June 2023

In the past decade, a number of cancer types have been reported to be associated with NCKAP1 encoded as a component of the WASF regulatory complex (WRC) and a poor prognosis. A study of the role of NCKAP1 across various types of tumors was conducted using data from The Cancer Genome Atlas (TCGA). There was an alteration in NCKAP1 expression in most tumor types when compared to corresponding non-tumor tissues. Survival analysis revealed that NCKAP1 overexpression was associated with poor OS and DFS only in kidney renal clear cell carcinoma (KIRC), and upregulated NCKAP1 expression was also significantly associated with the advanced cancer stage suggesting malignant progression in KIRC based on TCGA datasets using GEPIA2; Meanwhile, IHC staining showed NCKAP1 levels of KIRC tissues were significantly lower than normal tissues from HPA database. Following that, NCKAP1 alteration was associated with poor prognosis in cervical squamous cell carcinoma (CSCC) and lung adenocarcinoma (LUAD) patients in terms of PFS analyzed by cBioPortal. As a result, a positive correlation was observed between NCKAP1 expression and cancer-associated fibroblast infiltration in ACC, BRCA, CESC, LGG, and STAD. According to Gene Ontology analysis, NCKAP1 encodes a gene that regulates the actin cytoskeleton function. It was demonstrated from the protein interaction network that NCKAP1 interacts physically with CYFIP1, ABI2, WASF2 and BRK1, which have been well-characterized as actin cytoskeleton cycle regulators and cell disulfidptosis. There was a significant correlation between NCKAP1 expression and tumor prognosis in this multi-tumor study.
Robotic exoskeleton embodiment in post-stroke hemiparetic patients: an experimental study about the integration of the assistance provided by the REFLEX knee exoskeleton
Authors: Lora-Millan Julio S. , Sanchez-Cuesta Francisco José , Romero Juan Pablo , Moreno Juan C , Rocon Eduardo
Published: June 2023

Hemiparetic gait is the most common motor-disorder after stroke and, in spite of rehabilitation efforts, it is persistent in 50% of community dwelling stroke-survivors. Robotic exoskeletons have been proposed as assistive devices to support impaired joints. An example of these devices is the REFLEX knee exoskeleton, which assists the gait of hemiparetic subjects and whose action seems to be properly embodied by stroke survivors, who were able to adapt the motion of their non-assisted limbs and, therefore, reduce their compensation mechanisms. This paper presents an experimental validation carried out to deepen into the effects of REFLEX's assistance in hemiparetic subjects. Special attention was paid to the effect produced in the muscular activity as a metric to evaluate the embodiment of this technology. Significant differences were obtained at the subject level due to the assistance; however, the high dispersion of the measured outcomes avoided extracting global effects at the group level. These results highlight the need of individually tailoring the action of the robot to the individual needs of each patient to maximize the beneficial outcomes. Extra research effort should be done to elucidate the neural mechanisms involved in the embodiment of external devices by stroke survivors.
Analysis of hot research topics on environmental migration in a just transition
Authors: Liang Bing , Shi Guoqing , Hua Yinjie , Ye Taotao , Su Yu , Lu Zhongman
Published: June 2023

Global environmental issues have become one of the most prominent risk issues in society, and it is of great theoretical and practical importance to study the intrinsic correlation between environmental change and population migration in a just transition. Based on the Web of Science core ensemble database (WOS) and National Knowledge Infrastructure database (CNKI) sources, CiteSpace visual bibliometric software was used to construct a map of research hotspots in the field of environmental migration. The study found that the research hotspots of environmental migration mainly include (1) migration caused by environmental pollution; (2) migration caused by the construction of environmental protection projects; (3) migration caused by environmental protection activities; (4) migration caused by environmental degradation; (5) migration caused by climate change; (6) migration caused by environmental disasters; and (7) migration caused by environmental improvement activities. We propose the following recommendations for environmental migration research: (1) strengthen research on the predictive capability of environmental change-population migration models; (2) make use of China's useful exploration in resettlement fields such as engineering resettlement, ecological migration, and poverty alleviation resettlement to develop environmental migration policies and regulations and strategic planning; (3) establish a cloud platform for environmental changes and population migration-related databases; and (4) strengthen the exchange and cooperation between Chinese research scholars in the field of environmental migration and international research institutions.
The assessment of probabilistic seismic risk using ground-motion simulations via a Monte Carlo approach
Authors: Rudman Archie John , Douglas John , Tubaldi Enrico
Published: June 2023

Accurately characterizing ground motions is crucial for estimating probabilistic seismic hazard and risk. The growing number of ground motion models, and increased use of simulations in hazard and risk assessments, warrants a comparison between the different techniques available to predict ground motions. This research aims at investigating how the use of different ground-motion models can affect seismic hazard and risk estimates. For this purpose, a case study is considered with a circular seismic source zone and two line sources. A stochastic ground-motion model is used within a Monte Carlo analysis to create a benchmark hazard output. This approach allows the generation of many records, helping to capture details of the ground-motion median and variability, which a ground motion prediction equation may fail to properly model. A variety of ground-motion models are fitted to the simulated ground motion data, with fixed and magnitude-dependant standard deviations (sigmas) considered. These include classic ground motion prediction equations (with basic and more complex functional forms), and a model using an artificial neural network. Hazard is estimated from these models and then we extend the approach to a risk assessment for an inelastic single-degree-of-freedom-system. Only the artificial neural network produces accurate hazard results below an annual frequency of exceedance of 1x10− 3 years− 1. This has a direct impact on risk estimates - with ground motions from large, close-to-site events having more influence on results than expected. Finally, an alternative to ground-motion modelling is explored through an observational-based hazard assessment which uses recorded strong-motions to directly quantify hazard.
Responding to Human Trafficking among Refugees: Prevalence and Test Accuracy of a Modified Version of the Adult Human Trafficking Screening Tool
Authors: Stollwerck Estella Alejandra Tambini , Rollmann Ivo , Friederich Hans-Christoph , Nikendei Christoph
Published: June 2023

Background: Human trafficking is a human rights violation and urgent public health challenge. It involves the exploitation of a person by means of force, intimidation or deceit and causes severe health risks. Thoughit occurs all over the world, its true extent is still unknown. Refugees are especially vulnerable to human trafficking due to language barriers and difficult living conditions. Therefore, the purpose of this study was to design a screening tool to identify survivors of human trafficking among refugees in a German state registration and reception centre.
Methods: In cooperation with the local authorities, we asked newly arrived refugees at an initial reception centre in Southern Germany about their experiences with human trafficking. We used a combination of the Adult Human Trafficking Screening Tool and a publication by Mumma et al. to address all forms of exploitation. The results were cross-checked by a short interview afterwards.
Results: In total, 13 of the 176 asylum seekers had experienced trafficking, which corresponded to a prevalence of 7.3%. The questionnaire had a sensitivity of 76.9% and a specificity of 84.0% at a newly selected cut-off of six positive responses. In an exploratory descriptive analysis on subregions, refugees from West Africa had a substantially higher prevalence (33.3%) for human trafficking within our sample, especially women. However, when we excluded this region from our analysis, we found no significant gender difference for the rest of the sample.
Conclusions: The screening tool distinguishes reliably those who had experienced human trafficking from other refugees. The high prevalence of trafficking in most regions, regardless of gender, suggests that more effort is needed to identify and protect all trafficked persons.
Identification and molecular characterization of a novel species of the genus Totivirus from Areca catechu L.
Authors: Huang Xi , Tan Hang , Zhao Ruibai , Wang Hongxing
Published: June 2023

In previous work, RNA-seq was applied to identify the causal agent of yellow leaf disease (YLD) of areca palm (Areca catechu L.), besides a YLD related areca palm velarivirus 1 (APV1), a totivirus-like virus annotated as Panax notoginseng virus A (PnVA) was identified. Because the virus was also detected in many asymptomatical areca palm, it was therefore tentatively named Areca palm latent virus 1 (APLV1). The complete sequence of APLV1 was determined to be 4754 base pairs (bp) in length. Two deduced proteins encoded by APLV1 have 55% and 69 % amino acid (aa) sequence identity with CP and RNA-dependent RNA polymerase (RdRp) of Bursera graveolens associated totivirus 1 (BgAT1), respectively. Phylogenetic analysis based on alignment of the CP and RdRp sequences clustered APLV1 with other members of the genus Totivirus, suggesting that APLV1 might be a novel species of the genus Totivirus, family Totiviridae.
Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy
Authors: Liu Di , Song Yanling , Chen Hui , You Yuchan , Zhu Luwen , Zhang Jucong , Xu Xinyi , Hu Jiahao , Huang Xiajie , Wu Xiaochuan , Xu Xiao-Ling , Jiang Saiping , Du Yong-Zhong
Published: June 2023

Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepared F(ab′)2 fragmented vascular endothelial growth factor receptor 2 antibody (anti-VEGFR2 (F(ab′)2) to block VEGFR2 overactivation in diabetic nephropathy (DN). We found that the anti-VEGFR2 F(ab′)2 had a higher accumulation in DN mice kidneys and a comparable VEGFR2 combination with the intact VEGFR2 antibody. Furthermore, we developed an antibody fragment drug conjugate, anti-VEGFR2 F(ab′)2-SS31, comprising anti-VEGFR2 F(ab′)2 fragment linked to the mitochondria-targeted antioxidant peptide SS31. We found that introduce of SS31 potentiated the efficacy of anti-VEGFR2 F(ab′)2. These findings provide proof of concept for the premise that antibody fragment drug conjugate improves renal distribution and merits drug validation in renal disease therapy.
Hybrid tape versus synthetic tape in treatment of female stress urinary incontinence .A prospective clinical study
Authors: Mansy Islam , Elsayed Diab , saafan ahmed , Abouhashem Safwat E , Taha Kareem M , Samaha Ibrahem Ismael , Eliwa Ahmed M
Published: June 2023

Objective:
To compare the clinical and operative outcomes of hybrid tape versus synthetic tapes during mid-urethral sling in treating female stress urinary incontinence (SUI).
Patients and methods:
This prospective study included 60 women with SUI. Patients were categorized into two groups: Group I included 30 patients who underwent midurethral sling procedure using hybrid tape; and Group II included 30 patients that had synthetic sling, using trans obturator tape approach (TOT) in both groups . The following variables were compared: operative time, post operative pain scores, duration of indwelling urethral catheter, hospital stay, and QoL assessment (International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form [ICIQ-UI-SF]) before and after discharge from hospital.
Results:
Patients among the two groups were normally distributed with no statistically significant difference in patient’s demographic data and comorbidities. There was an obvious increase in operative time in group I compared to group II. This increase was statistically highly significant. (p <0.001).
Conclusion:
Hybrid tape should be considered as a treatment option during TOT for female SUI with comparable efficacy and safety to synthetic tape. Long term follow up should be considered.
Subject classification codes: include these here if the journal requires them
Characteristics analysis of chloroplast genome and molecular evolution of chloroplast genes in Amaryllidaceae plants
Authors: Chen Dan , Fu Chun
Published: June 2023

BackgroundAmaryllidaceaeis a family of Monocotyledons inLiliflorae, and is considered an important ornamental and economic plant due to its usually showy flowers, and theAmaryllidaceaealso has enormous medicinal value. Currently, the gene structure characteristics and molecular function analysis of all chloroplast genomes inAmaryllidaceaeare rarely reported, so this study mainly analyzed the gene structure characteristics and molecular function of all chloroplast genomes inAmaryllidaceaeto reveal the characteristics of the chloroplast genome ofAmaryllidaceaeplants and explore their evolution and development patterns, and it usedbioinformaticsmethods to analyze the chloroplast genome sequences of 64Amaryllidaceaeplants that have been published on NCBI. Results Among the 64 species ofAmaryllidaceaeplants, the species with a gene number of 86 had the most chloroplasts, with 38 species accounting for approximately 59%. The number of rRNAs in its chloroplast genome is all 8. There are 55 species of plants in theAmaryllidaceaewith 38 tRNAs, and only a few species have abnormal tRNA numbers in their chloroplast genomes due to the loss or duplication of tRNA genes. The GC content of chloroplast genomes in all species ranges from 36–39%, indicating that their AT content is roughly between 61–64%. The high proportion of AT content in chloroplast genomes indicates that chloroplast codons prefer to use A/T bases. By constructing a phylogenetic evolution tree, it was found that the 64 species ofAmaryllidaceaeplants can be divided into 12 evolutionary groups.Lycoris longitubaandLycoris anhuiensishave the fastest evolutionary speed, whileAllium przewalskianumandAllium polyrhizum CMS-Shave the most primitive and slowest evolutionary speed. By analyzing the codon preference of chloroplast genomes, it was found that plants in theAmaryllidaceaeprefer to use synonymous codons ending in A/U, and their chloroplast genome codon usage bias is weak. Conclusion Our results preliminarily explored the relationship between each species in Amaryllidaceae, and the characteristics of the entire chloroplast genome sequence ofAmaryllidaceaewere revealed, these results provide a certain theoretical basis for further research on the plants of theAmaryllidaceaefamily in the future.