bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulatory adaptive status in determining the effectiveness of nebivololum and sotalolum in patients with hypertensive disease and paroxysmal atrial fibrillation
Authors: Eremina M A , Tregubov V G , Pokrovsky V M
Published: February 2021

Aim: compare the effectiveness of treatment with nebivololum or sotalolum in patients with hypertensive disease (HD) and paroxysmal atral fibrillation (AF) taking into account quantitative evaluation of the regulatory adaptive status (RAS). Materials and methods. 50 patients with HD of stages II-III and paroxysmal AF took part in the research, they were randomized into two groups for treatment with nebivololum (5.6±1.6 mg/day n=25) or sotalolum (157.0±38.3 mg/day, n=25). As part of combination therapy, patients were administered lisinoprilum (14.3±3.7 mg/day and 14.4±3.9 mg/day), when required alsoatorvastatinum (18.8±4.4 mg/day, n=11 and 16.0±5.1 mg/day, n=12), acetylsalicylic acid (91.2±14.1 mg/day, n=11and 92.1±16.8 mg/day, n=11), respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, controlled arterial hypertension, effectively suppressed paroxysms of AF, improved the quality of life. At the same time, the use of nebivololum increased the RAS and increased exercise tolerance, to a lesser degree than the use of sotalolum. Conclusion. In patients with HD of stages II-III and paroxysmal AF the use of nebivololum as part of combination therapy may be preferable to sotalolum due to its positive impact on the RAS.
Evaluating of the effectiveness and safety of the reproduced selective β1-blocker without intrinsic sympathomimetic activity Bidop® in patients with hypertrophic cardiomyopathy
Authors: Feiskhanova L I , Malov A A
Published: February 2021

The article assesses the effectiveness of therapy generics Bidop® production of Gedeon Richter (Hungary), designated to improve diastolic function, and treatment of heart failureof patients with hypertrophic cardiomyopathy with predominant hypertrophy of the interventricular septum and symmetrical concentric shape in the absence of obstruction of outflow tract of the left ventricle (LV). The effect of the presence of zones of intramyocardial fibrosis hypertrophied LV departments identified through MRI delayed contrast, to the process of active relaxation.
The choice of antihypertensive therapy in correction of cognitive impairments and prevention of dementia: possibilities of valsartan and fixed-dose combination of valsartan and hydrochlorothiazide
Authors: Ostroumova O D , Garelik I A , Karavashkina E A
Published: February 2021

This article discusses the definition, classification and pathogenetic mechanisms of cognitive functions in arterial hypertension. The authors discuss the capabilities of the different classes of antihypertensive drugs in correction of cognitive impairments and prevention of dementia. The authors also discuss the advantages of the angiotensin II receptor blockers in prevention of dementia and in their potential mechanisms of cerebral protection. The article describes in detail the possibilities of valsartan in correction of cognitive impairments associated with arterial hypertension, the advantages of valsartan in comparison with calcium antagonists and its unique neuroprotective mechanisms. We show our own results of the study concerning fixed-dose combination of valsartan and hydrochlorothiazide, and find out that this combination has high antihypertensive and cerebral protection (capacity to improve cognitive function) and effectiveness.
Treatment of patients with high cardiovascular risk: a modern view on combined therapy
Authors: Blankova Z N , Aslanian N S , Smolianinova N G , Ageev F T
Published: February 2021

Introduction. Lack of efficacy of treatment with several medications in patients with arterial hypertension (AH) and high cardiovascular disease (CVD) risk is often explained by low compliance to treatment. Using combined therapy (CT) is one of the ways to increase compliance. Objective. To evaluate the influence of CT consisting of amlodipine, lisinopril and rosuvastatin on arterial elastance and serum fibrosis marker levels in patients with high CVD risk. Materials and methods. The study included 66 patients (mean age 66.5 years, 5% male, 95% female) with atherosclerosis of the brachiocephalic arteries. Serum levels of cholesterol and low density lipoprotein (LDL); brachial and central blood pressure (BP); brachial-ankle and carotid-femoral pulse wave velocity (baPWV and cfPWV, respectively); and augmentation index (AI) were determined initially and after 6 months of CT. Results. Against the background of CT statistically significant reduction of levels of LDL from 4.1 (3.6; 4.7) to 2.2 (1.8; 2.5) mmol/L (p
Balloon angioplasty as an alternative to thromboendarterectomy for proximal pulmonary artery obstruction in a patient with chronic thromboembolic pulmonary hypertension: a case report
Authors: Danilov N M , Matchin Yu G , Iarovoi S Yu , Demchenkova A Yu , Chazova I E
Published: February 2021

Thromboendarterectomy is undoubtedly the most widely used method in chronic thromboembolic hypertension treatment. Although surgical treatment is highly effective, it is often associated with high risk of complications. One of the main reasons for impossibility of surgery performance is distal pulmonary artery obstruction. In this case medical therapy or staged balloon angioplasty is considered the treatment of choice. This case report discusses if pulmonary artery angioplasty can be used in patients with proximal pulmonary artery obstruction.
Fixed combination of highly selective β-adrenoblocker bisoprolol and calcium antagonist amlodipine (Concor® AM) for arterial hypertension treatment in metabolic disorder patients
Authors: Zhernakova Yu V , Martyniuk T V , Arkhipova O A , Azimova M O , Rogoza A N , Chazova I E
Published: February 2021

Introduction. Combination therapy is widely used in treatment of patients with arterial hypertension (AH) of high and very high cardiovascular risk. Fixed combinations (FC) of medications are preferable and it is important to develop new effective and safe ones. Organ-protective effects are also significant. Objective. To study antihypertensive effectiveness of new FC of highly selective β-adrenoblocker bisoprolol and calcium antagonist amlodipine (Concor® AM), its influence on cardiometabolic risk factors and target lesions in metabolic disorder patients with AH of stages 1 or 2. Materials and methods. The study included 30 patients (13 male, 17 female, mean age 47.20±0.22 years) with AH of stages 1 or 2 and metabolic syndrome (MS). All patients underwent clinical assessment of blood pressure (BP); levels of serum cholesterol (SCL), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride, creatinine, and glucose in oral glucose tolerance test; 24-hour blood pressure monitoring; central systolic blood pressure (CSBP); carotid-femoral pulse wave velocity (cfPWV), and intima-media complex thickness which were determined initially and after 6 months of therapy with FC. Results. The target level of BP was reached by 88% patients after treatment with Concor® AM. Significant deceleration of heart rate (from 74.95±2.20 to 68.81±1.13 bpm) and CSBP (from 151.7 to 132.6 mm Hg) were observed. Treatment with Concor® AM led to artery stiffness decrease evaluated by cfPWV decrease (from 14.21±0.45 to 12.1±0.23 m/s, p≤0.05). Conclusion. FC of highly selective β-adrenoblocker bisoprolol and calcium antagonist amlodipine (Concor® AM) was shown effective for AH treatment in patients with MS. Future research is recommended to investigate the effectiveness of FC therapy in a larger cohort of patients.
Achievement of the main goals of therapy by using of a triple fixed combination of amlodipine, indapamide and perindopril (Co-Dalneva®) in patients with arterial hypertension
Authors: Chukaeva I I , Spiryakina Ya G , Glibko K V , Orlov D A , Bayramova A S , Logunova I Yu
Published: February 2021

Introduction. Combined antihypertensive therapy is indicated in 94% of patients with hypertension. Fixed combinations are preferable to use as they have a high profile of effectiveness, safety, more convenient to use and significantly increase the adherence. Objective. To evaluate the effectiveness of triple fixed combination of amlodipine/indapamide/perindopril for the control of blood pressure in patients who did not achieve the target blood pressure level in the previous combined therapy. Materials and methods. The study included 44 patients with hypertension of high and very high risk of cardiovascular complications (mean age - 58.59±10.57 years, 17 men, 27 women). Blood pressure levels, quality of life, anxiety and depression levels, adherence, biochemical indices, levels of inflammation markers (CRP, IL-6, IL-10) and endothelial dysfunction (sVCAM-1, VEGF) were assessed in all patients at baseline and after 6 months of amlodipine/indapamide/perindopril therapy. Results. Against the backdrop of the treatment, all patients reached the target level of blood pressure (BP), pulse BP decreased by 30.3 mm Hg. (p
Survival of patients with pulmonary arterial hypertension during therapy PAH-specific drugs
Authors: Platonov D Yu , Tsareva N A , Avdeev S N
Published: February 2021

Pulmonary arterial hypertension (PAH) is a life threatening syndrome, which is characterized by a progressive increase in pulmonary vascular resistance (PVR), medium pulmonary artery pressure and functional disorders and morphological changes of pulmonary arteries. Despite the relative abundance of PAH-specific drugs, the choice of a suitable agent for the treatment of a particular patient remains challenging. One of the most important parameters measured in clinical studies is patient survival or, in some cases, mortality. Survival or mortality as secondary or components of the primary endpoint one way or another has been studied in clinical trials of drugs for the treatment of PAH. For tablets drugs for the treatment of some forms of PAH (sildenafil, riociguat, bosentan, macitentan, ambrisentan) currently available data studies, which studied the survival.
Dynamics of clinico-psychological characteristics in patients with obstructive sleep apnea syndrome and arterial hypertension after one month of the use of CPAP therapy
Authors: Konovalova K I , Elfimova E M , Mikhailova O O , Fedorova V I , Litvin A Yu
Published: February 2021

Objective. To determine the dynamics of the clinical and psychological characteristics on the background of 1 month of CPAP therapy in patients with obstructive sleep apnea syndrome (OSA) and arterial hypertension (AH), both adherent and non-adherent to the treatment. Methods. The study included 180 patients with OSA and AH. Upon enrollment, anthropometric data, the results of polysomnography and cardiorespiratory studies, Beck depression scale, Spielberger personal and situational anxiety scale, Epworth daytime sleepiness scale, Pittsburgh sleep quality questionnaire and Quality of Life (WHO QOL-100) questionnaire were analysed. Out of 40 patients undergoing CPAP therapy, 30 patients were adherent to the treatment within a month. The adherence criterion was considered to be the usage of the CPAP device more than 4 hours per night, more than 5 days a week. In this article, the dynamics of the questionnaire scales is given only for those who were adherent to CPAP therapy. Results. Patients with OSA and AH adherent to CPAP therapy showed a statistically significant reduction in daytime sleepiness and depression, as well as improved quality of sleep and quality of life in the physical domain within 1 month of using CPAP therapy. Conclusion. Even short-term use of CPAP therapy in patients with OSA and AH leads to a reduction in daytime sleepiness and depression, improved quality of sleep and quality of life in the physical domain.
Prevention of cardiovascular events at patients with arterial hypertension at treatmentangiotensin-converting enzyme inhibitor.
Authors: Kislyak Oksana Andreevna , Postnikova Svetlana Vladimirovna
Published: February 2021

Angiotensin-converting enzyme inhibitor is one of basic antihypertensive drugs for treatment of arterial hypertension at first stages of
the disease. The review summarizes the data on different ACE inhibitors.
Diuretics in treatment of patients with arterial hypertension
Authors: Chazova Irina Evgen'evna , Ratova Lyudmila Gennadievna
Published: February 2021

Since all cardiovascular risk factors contribute to coronary artery disease in patients with arterial hypertension, they should all be considered in the management
of this disease process. Thiazides diuretics when used at high doses, negatively impact lipid and glucose metabolism. These findings have resulted in
decreased use of diuretics in favor of newer agents such as ACE inhibitors and calcium antagonists. However, recent data have demonstrated that when
used at low doses (6.25 or 25 mg of hydrochlorothiazide), diuretics lack significant metabolic side effects while bringing about significant reductions in blood
pressure. Thus, at these doses, hydrochlorothiazide is a useful drug in the treatment of hypertension, both as monotherapy and in combination therapy.
Angiotensin receptor blockers in nephroprotection at patients with diabetes mellitus: focus on losartan
Authors: Vikulova Ol'ga Konstantinovna , Shestakova Marina Vladimirovna
Published: February 2021

Many large studies have provided strong evidence that there is an association of elevated BP with a risk for cardiovascular events (CVE),
such as stroke, myocardial infarction and heart failure. But none of the studies has indicated that a drug is more effective than another one
in reducing the risk for CVE and death. The article summarizes the available data on ramipril in hypertensive patients of high cardiovascular
risk. The results of studies demonstrate strong and long-lasting antihypertensive effect of losartan. Moreover, losartan treatment
decreases cardiovascular events rate, damage of target organs, atherosclerosis progression and new cases of diabetes mellitus. Losartan
shows both high efficacy and low adverse event rate.
The modern treatment of cardiovascular diseases with b-blockers - focus on the nebivolol.
Authors: Evdokimova Anna Grigor'evna , Ol'khin Valeriy Aleksandrovich , Evdokimov Vladimir Vyacheslavovich , Zolotareva Ekaterina Viktorovna , Khadzegova Alla Blalovna
Published: February 2021

Unlike first-line antihypertensives, nebivolol, a cardioselective b-blocker with vasodilatatory properties caused by its ability to modulate the activity of nitric oxide, positively affects prognosis in patients with arterial hypertension and chronic heart failure and shows metabolic neutrality. The clinical and pathogenetic studies demonstrating the benefits of nebivolol are discussed.
Keywords: nebivolol, arterial hypertension, b-blockers.
Candesartan in the prevention of cardiovascular catastrophes: emphasis on the pre-vention of stroke
Authors: Drapkina Oksana Mikhaylovna , Dikur Oksana Nikolaevna
Published: February 2021

Arterial hypertension is one of the most important risk factors of acute cerebral circulatory disorders. Many clinical studies indicate that there are mechanisms that permit the prevention of stroke irrespective of a direct reduction in blood pressure. Antihypertensive agents affecting the renin-angiotensin-aldosterone system may have a cerebral protective effect beyond blood pres-sure lowering. The ability of angiotensin II receptor antagonists to prevent the development of stroke is associated with the fact that with the use of these agents, angiotensin II interacts with AT2-receptors, thereby improving the blood flow in the brain and enhancing the neuronal resis-tance to hypoxia. In this review, the focus is on the capacity of the angiotensin II receptor an-tagonist candesartan to prevent severe cerebrovascular events.
DISTORTED COGNITIVE PATTERNS AS THE CAUSE OF IRRATIONAL BEHAVIOR
Authors: Бенелли Анджело Витторио , Бенелли Лана Николаевна , Рассказова Алла Львовна
Published: February 2021

Обсуждаются проблемы понимания причин иррационального поведения личности через призму когнитивного подхода: обосновывается влияние искаженных когнитивных схем на формирование иррациональных убеждений и установок, лежащих в основе неадаптивного поведения. Описываются детерминанты поведения человека в обществе через парадигму когнитивных схем. Рассматривается возможность изучения искаженных когнитивных схем личности через выявление психологических процессов, на которых основывается восприятие и принятие человеком решений. Делается предварительный вывод о том, что иррациональное поведение имеет социально-психологическую природу, в большинстве случаев обусловлено попыткой преодоления чувства субъективного эмоционального неблагополучия и обусловлено сложившимися у личности искаженными когнитивными схемами.

The article discusses the problems of understanding the causes of irrational behavior of a person through the prism of a cognitive approach: the influence of distorted cognitive schemes on the formation of irrational beliefs and attitudes underlying maladaptive behavior is justified. The article describes the determinants of human behavior in society through the paradigm of cognitive schemes. We consider the possibility of studying distorted cognitive patterns of the individual through the identification of psychological processes on which the perception and decision-making of a person is based. The article makes a preliminary conclusion that irrational behavior has a socio-psychological nature, in most cases it is caused by an attempt to overcome a sense of subjective emotional distress and is caused by the distorted cognitive patterns that have developed in the individual.
LEADERSHIP STYLE AS A FACTOR IN THE PROFESSIONAL PERFORMANCE OF SALES MANAGERS
Authors: Милюкова Ольга Вячеславовна , Чечурова Юлия Юрьевна
Published: February 2021

Представлен теоретический анализ основ и эмпирическое изучение стиля руководства как факторы психологической и экономической эффективности профессиональной деятельности менеджеров по продажам банковских услуг. Доказана важность использования производственно-командного и социального стиля управления, где руководитель имеет направленность в своей деятельности и на потребности сотрудников, и на организационные задачи.

The article presents theoretical analysis of the basics and empirical study of the style of management as a factor of psychological and economic efficiency of professional activity of sales managers of banking services. The importance of the use of production-command and social management style has been proved, where the manager has a focus in his/her activities both on the needs of employees and on organizational tasks.
TEENAGE-YOUTH CRIMINAL MOVEMENT «A.U.E.»: PHENOMENOLOGY AND PSYCHOLOGICAL-CRIMINOLOGICAL CHARACTERISTIC
Authors: Клейберг Юрий Александрович
Published: February 2021

С психолого-криминологических позиций представлен современный подростково-молодежный феномен «А.У.Е» («Арестантское уркаганское единство»), характеризующийся криминальным поведением. Освещаются основные причины, признаки и черты «А.У.Е.».

The article presents from a psychological and criminological point of view the modern teenage and youth phenomenon «A.U.E.» («Prisoner of Urkagan unity»), characterized by criminal behavior. The main causes, signs and features of the AUE are highlighted.
FEATURES OF VALUE ORIENTATIONS OF REPRESENTATIVES OF VARIOUS SUBCULTURAL YOUTH GROUPS
Authors: Попкова Татьяна Алексеевна , Травина Светлана Анатольевна
Published: February 2021

Уточняется понятие субкультуры как института социализации личности. Через данные эмпирического исследования представителей различных субкультур современной молодежи - «блогеров», «ютуберов», «байкеров» и «рокеров» - раскрывается специфика их терминальных ценностей и ценностных, а также смысложизненных ориентаций. Дается авторская интерпретация статистически значимых взаимосвязей заявленных параметров.

The article clarifies the concept of subculture as an institution of socialization of personality. Through data of empirical research of representatives of various subcultures of modern youth: "bloggers", "youtubers", "bikers" and "rockers" the specificity of their terminal values and value orientations, and also life orientations is revealed. The author's interpretation of statistically significant relationships of the declared parameters is given.
MODERN STUDENTS AND DIGITAL LEARNING ENVIRONMENT
Authors: Борисова Елена Владимировна
Published: February 2021

В статье рассмотрено своеобразие современной системы высшего образования, обусловленное требованиями общества, расширением цифровых инструментов и ресурсов, обновлением педагогических подходов и отличительными чертами студентов. Отмечен ряд преимуществ цифровой среды, предполагающей изменение формата образовательного процесса средствами комбинирования методов обучения на базе цифрового контента. Приведены методика и результаты авторского исследования, отражающие позитивное, в целом, отношение современных студентов к методам обучения и контроля, широко использующим цифровые компоненты.

The article considers the originality of the modern system of higher education, due to the requirements of society, the expansion of digital tools and resources, updating pedagogical approaches and the hallmarks of students. A number of advantages of the digital environment, which involves changing the format of the educational process by combining teaching methods based on digital content, are noted. The methodology and results of the author's research are presented, reflecting the positive, in general, attitude of modern students to teaching and control methods that widely use digital components.
THE DEVELOPMENT OF THE CONTENT OF VOCATIONAL TRAINING OF MASTER’S DEGREE STUDENTS TO MANAGEMENT IN PRESCHOOL EDUCATION
Authors: Селиверстова Ирина Анатольевна , Семенова Марина Леонидовна
Published: February 2021

Рассматриваются вопросы подготовки будущих специалистов дошкольного образования к управленческой деятельности. Целью исследования является установление взаимосвязи между требованиями стандарта высшего образования, рынка труда и работодателя как основание отбора профессиональных компетенций при проектировании содержания образовательной программы магистратуры. Авторами использованы метод теоретического анализа, сопоставление реальных запросов практики в целом и задач подготовки будущих руководителей. В результате обозначены профессиональные компетенции и индикаторы их достижения, востребованные работодателем. Выводы и предложения авторов интересны в теоретическом и прикладном плане, могут быть применены при разработке и реализации программ подготовки высококвалифицированных социально активных кадров дошкольного образования.

Discusses the preparation of future pre-school education specialists for management activities. The aim of the study is to establish a relationship between the requirements of the higher education standard, the labour market and the employer as a basis for selecting professional competencies in the design of the content of the master's education program. The authors used a method of theoretical analysis, comparing the actual requests of practice in general and the tasks of training future managers. As a result, the professional competences and indicators of their achievements, demanded by the employer, are marked. The authors' conclusions and proposals are interesting in theory and application, and can be applied in the development and implementation of training programs for highly qualified, socially active pre-school education.
New details of the male terminalia of Diathoneura longipennis (Malloch, 1926) (Diptera, Drosophilidae)
Authors: Vilela Carlos R. , Bächli Gerhard
Published: February 2021

The male terminalia of a non-type Diathoneura longipennis (Malloch 1926) specimen,collected in Peru, were dissected and analyzed. The aedeagus and associated sclerites were found tohave been fixed at a late stage of protrusion, resulting in a different morphology, when compared to thetwo previous publications, which were fixed at earlier stages. Consequently, additional details of certainanatomical parts were observed and a better understanding of the aedeagus protruding process was attained.Diathoneura longipennis has been previously identified in San Mateo, Alajuela, Costa Rica (type locality)and Panama, and this specimen represents the first record of this species in South America.
Análisis del potencial genotóxico y carcinógeno asociado a los cigarrillos electrónicos
Authors: Armendáriz - Castillo Isaac , Guerrero Santiago , Vera-Guapi Antonella , Cevallos-Vilatuña Tiffany , Garcí­a-Cárdenas Jennyfer M. , Guevara-Ramí­rez Patricia , López-Cortés Andrés , Pérez-Villa Andy , Yumiceba Verónica , Zambrano Ana K. , Leone Paola E. , Paz y Miño Cesar
Published: February 2021

Diferentes estudios que comparan riesgos a la salud asociados a los usos de cigarrillos electrónicos y convencionales, se enfocan principalmente en compuesto quí­micos en común entre ambos sistemas. Por lo tanto, realizamos una revisión de compuestos quí­micos exclusivos de cigarrillos electrónicos. Los criterios de selección incluyeron artí­culos que reporten composición quí­mica y riesgos asociados a la salud, sin conflictos de interés. Todos los compuestos quí­micos fueron clasificados según el código del "Chemical Abstracts Service" para sustancias quí­micas. Un total de 57 compuestos fueron identificados en cigarrillos electrónicos. Para analizar los efectos carcinogénicos, un set de genes, previamente reportados como desregulados en el epitelio oral de usuarios de cigarrillos electrónicos, fueron genómicamente analizados en 32 estudios del "PanCancer Atlas". Los riesgos a la salud más importantes incluyen: irritación de tracto respiratorio, ojos y piel con un 50% de incidencia. Los tipos de cáncer con mayor riesgo identificados fueron: ovario, útero, vejiga, pulmón, esófago y estómago. A pesar de ser considerados como menos dañinos que los cigarrillos convencionales, el uso de cigarrillos electrónicos no es recomendado para ningún usuario, debido a falta de evidencia experimental.
The Chief Data Officer's Playbook
Authors: Carruthers Caroline , Jackson Peter
Published: February 2021

This fully revised and updated edition of the bestselling Chief Data Officer's Playbook offers new insights into the role of the CDO and the data environment. Written by two of the world's leading experts in data driven transformation, it addresses the changes that have taken place in 'data', in the role of the 'CDO', and the expectations and ambitions of organisations. Most importantly, it will place the role of the CDO into the context of a c-suite player for organisations that wish to recover quickly and with long-term stability from the current global economic downturn.New coverage includes:the evolution of the CDO role, what those changes mean for organisations and individuals, and what the future might holda focus on ethics, the data revolution and all the areas that help readers take their first steps on the data journeynew conversations and experiences from an alumni of data leaders compiled over the past three yearsnew chapters and reflections on being a third generation CDO and on working across a broad spectrum of organisations who are all on different parts of their data journey.Written in a highly accessible and practical manner, The Chief Data Officer's Playbook, Second Edition brings the most up-to-date guidance to CDO's who wish to understand their position better; to those aspiring to become CDO's; to those who might be recruiting a CDO and to recruiters to understand an organisation seeking a CDO and the CDO landscape.
Morphometrics Variations of Carpenter Bees Xylocopa confusa Latreille and Xylocopa latipes Drury from Different Habitats in Central Sulawesi
Authors: Windarsih Yulia , Trianto Manap
Published: February 2021

Habitat is a place for living things to grow and develop. Differences in physical characteristics of habitats within an area can affect the morphometry of an organism. This study aims to provide information related to the morphometric variation of the carpenter bees Xylocopa confusa Latreille and Xylocopa latipes Drury in different habitats in Central Sulawesi. The research was conducted in four types of habitat, namely primary forest, secondary forest, rural areas, and urban areas in January 2019. The collection of carpenter bees useds a sweep net by swinging it around the sampling location. The carpenter bees obtained were then killed in a killing jar for five minutes. The carpenter bees samples were put into a sample bottle based on the type of habitat. Furthermore, the pinning process was carried out using insect needles. The results showed that the physical characteristics of the different habitats could affect the morphometric variations of the carpenter bees Xylocopa confusa and Xylocopa latipes. The size of the body morphometry of carpenter bees is larger in primary forest habitats, while the smallest size of bees is found in urban areas. This research is useful as preliminary data before carrying out the cultivation and conservation process of wood bees considering that their role in nature is very important.
The Mediating Role of Real-Time Information Between Location-Based User-Generated Content and Tourist Gift Purchase Intention
Authors: KHAN Mustafa , KHAN Haseeb , VACHKOVA Maya , GHOURI Arsalan
Published: February 2021

The global use of Web 2.0 applications has generated enormous volumes of user content. Drawing on cognitive load theory, this study examines unexplored factors that influence gift purchase intention of tourists. The authors identify localization and real-time information for shaping tourists' gift purchase intention, which is facilitated by reduced cognitive overload. Analyzes of the study relies on a sample of 273 foreign tourists in Malaysia. A cross-sectional quantitative study is conducted using partial least square structural equation modeling. Results showed that location-based user-generated content and real-time information significantly affect gift purchase intention of tourists. Moreover, real-time information partially mediates the relationship between location-based user-generated content and gift purchase intention.
Analisis Efektivitas Biaya Penggunaan Obat Antiretroviral Atripla dan T/H/A pada Pasien HIV Rawat Inap RSUD Raden Mattaher Provinsi Jambi Tahun 2017-2018
Authors: Permatasari Jelly , Wicaksono Disty Aldila , Andriani Medi
Published: February 2021

Human Immunodeficiency Virus (HIV) telah manjadi masalah darurat global. HIV merupakan penyakit kronis yang membutuhkan pengobatan seumur hidup. Infeksi yang disebabkan oleh HIV ini dapat menurunkan sistem kekebalan tubuh sehingga menimbulkan infeksi oprtunistik pada penderita. Infeksi opurtunistik tersebut dapat memperpanjang lama rawatan pada penderita, sehingga menambah biaya pengobatan HIV. Penelitian ini  merupakan studi farmakoekonomi. Sampel diperoleh dari data rekam medis pasien HIV rawat inap tahun 2017-2018 yang memenuhui kriteria inklusi yang diambil secara  purposive sampling. Sampel yang memenuhi kriteria inklusi berjumlah 24 orang. Persentase kelompok usia pasien 17-25, 26-35, 36-45, dan 46-55 tahun masing-masing sebesar 33,33; 33,33; 29,17; dan 4,17%. Persentase jenis kelamin laki-laki dan perempuan masing-masing 54,17 dan 45,83%. Pekerjaan pasien meliputi wiraswasta (41,67%), IRT (41,67%), petani (8,33%), pegawai swasta (8,33%). Persentase lama rawatan <9 hari dan >9 hari masing-masing sebesar 83,33 dan 16,67%. Antiretroviral (ARV) yang digunakan adalah atripla (EFV 600 mg, AZT 300 mg, TDF 300 mg) dan T/H/A (kombinasi TDF 300 mg, hiviral/lamivudine 150 mg, dan aluvia (lopinavir/ritonavir 200 mg/50 mg)), yaitu sebesar 66,67 dan 33,33%. Rata-rata biaya medis langsung atripla sebesar Rp1.547.713,00, sedangkan pada T/H/A sejumlah Rp2.962.642,00. Persentase efektifitas atripla adalah 87,5%, sedangkan T/H/A sebesar 75%. Nilai incremental cost-effectiveness ratio (ICER) sebesar -113.194,32. Analisis efektifitas biaya penggunaan ARV pada pasien rawat inap di RSUD Raden Mattaher Provinsi Jambi pada tahun 2017-2018 menunjukkan bahwa atripla merupakan ARV yang paling efektif secara biaya dan outcome (lama rawat).
Penetapan Parameter Standar Simplisia dan Ekstrak Etanol Daun Ganitri (Elaeocarpus serratus L.)
Authors: Kiromah Naelaz Zukhruf Wakhidatul , Septiani Sinta Wahyu , Rahmatulloh Wahyu , Aji Ari Purnomo
Published: February 2021

Ceylon olive (Elaeocarpus serratus L.) leaves have shown many pharmacological effects. Standardization of crude drug and extract needs to be conducted to assure the quality of the said material and further to support the pharmacological, pharmacokinetics, and toxicity effects. Standardization of Ceylon olive leaf extract is carried out to determine the standard parameters of crude drug and ethanolic extract of Ceylon olive leaves. Determination of the quality standard of crude drug and extract includes specific and non-specific parameters. The extract was obtained from a 70% ethanol maceration method with a yield of 16.02%. Macroscopic observations showed crude drugs of Ceylon olive leaves occurred as green in color, lanceolate leaves, 2-12 mm stems, and jagged leaves not deep, black spots, 10-15 side leaf bones, 6-18 cm long and 2-6 cm wide. Organoleptic of ethanolic extract of Ceylon olive showed thick consistency, blackish-brown colored, with a distinctive odor and a bitter taste. The water-soluble extractive value in crude drugs and extract was 16.48 and 51.54%, while the ethanol-soluble extractive value was 23.17 and 53.67%, respectively. The extract contained tannins, flavonoids, terpenoids, and saponins. Moisture content in the crude drugs and extracts was 22.09 and 25.53%. Total ash content in crude drugs and extracts was 33.53 and 30.62%, while their acid-insoluble ash content was 15.94 and 10.06%, respectively. Loss on drying of the crude drugs and extracts was 20.52 and 23.84% respectively. As the standard parameters of crude drugs and ethanolic extract of Ceylon olive leaves are not yet included in any formal monograph in Indonesia, the values of parameters reported in this study should be used as the reference of the standard quality parameter for those materials.
Hubungan Durasi Terdiagnosis Diabetes Melitus Tipe 2 dan Kadar Gula Darah Sewaktu Dengan Kejadian Retinopati Diabetik di Rumah Sakit Budi Kemuliaan Kota Batam Tahun 2017-2018
Authors: Sahreni Sukma , Isramilda Isramilda , Saputra Andi Ipaljri
Published: February 2021

Hubungan Durasi Terdiagnosis Diabetes Melitus Tipe 2 Dan Kadar Gula Darah Dengan Kejadian Retinopati Diabetik Di Rumah Sakit Budi Kemuliaan Kota Batam Tahun 2017-2018. Retionopati Diabetik merupakan salah satu komplikasi mikrovaskular Diabetes Melitus yang disebabkan oleh kerusakan pembuluh darah di retina dan dapat menimbulkan kebutaan yang permanen. Retinopati diabetes merupakan respon target organ terhadap penyakit sistemik dan hanya merupakan salah satu dari berbagai komplikasi mikrovaskular dari Diabetes mellitus. Jenis penelitian ini merupakan penelitian analitik observasional dengan pendekatan studi case control, dengan menelaah hubungan antara efek (penyakit atau kondisi kesehatan) tertentu dengan faktor risiko tertentu. Sampel pada penelitian ini berjumlah 66 orang. Teknik pengambilan sampel menggunakan Total sampling. Analisis data menggunakan uji chi-square. Dari hasil penelitian 66 orang yang diteliti sebanyak 38 (57,6%) orang memiliki durasi diabetes mellitus ≤5 tahun. Hasil Uji Risk Estimate menunjukkan nilai Odds Ratio (OR) = 6,500. OR >1 Yang artinya, peluang ≤5 tahun pasien Retinopati Diabetik memiliki resiko diabetes melitus tipe 2 sebesar 6,500 lebih tinggi daripada pasien >5 tahun. Hasil Uji Risk Estimate menunjukkan nilai Odds Ratio (OR) = 3,200. OR >1 Yang artinya, Kadar Gula Darah terkontrol dengan tidak terjadi Retinopati Diabetik memiliki resiko sebesar 3,200 lebih tinggi daripada dari pada yang terjadi Retinopati. Berdasarkan hasil penelitian ini dapat di simpulkan bahwa ada hubungan yang signifikan antara Diabates Melitus tipe 2 dan kadar gula darah sewaktu dengan kejadian Retinopati Diabetik di Rumah Sakit Budi Kemuliaan Kota Batam tahun 2017 – 2018.
Pemanfaatan Teknologi Informasi dan Komunikasi (TIK) Dalam Pembelajaran di Sekolah
Authors: Siregar Zakaria , Marpaung Topan Bilardo
Published: February 2021

Teknologi pendidikan sering dikacaukan dengan istilah teknologi pengajaran. Teknologi pengajaran merupakan bagian dari teknologi pendidikan, hal ini didasarkan pada konsep bahwa pengajaran adalah bagian dari pendidikan. kedepan, arus perkembangan TIK akan melaju semakin cepat dan menuntut manusia untuk dapat beradaptasi dengan perkembangan supaya tidak ketinggalan zaman, serta untuk menghadapi tantangan global. Dengan kondisi yang seperti ini, maka pendidikan tidak akan terlepas dari internet, komputer, dan fasilitas TIK lainnya sebagai alat bantu utama dalam proses pembelajaran. Untuk dapat memanfaatkan TIK dalam memperbaiki mutu pembelajaran, ada tiga hal yang harus diwujudkan, yaitu: 1. Peserta didik dan guru harus memiliki akses teknologi digital di dalam lingkungan lembaga pendidikan. 2. Adanya materi yang berkualitas dan bermanfaat bagi guru dan peserta didik. 3. Guru harus memiliki pengetahuan dan keterampilan dalam menggunakan media-media pembelajaran digital untuk membantu siswa agar mencapai standar akademik dan mengembangkan potensinya
Uji Komposisi Zat Pengatur Tumbuh Terhadap Pertumbuhan Eksplan Pisang Barangan (Musa paradisiaca L.) Pada Media MS Secara in vitro
Authors: Budi Rahmad Setia
Published: February 2021

Perbanyakan konvensional pisang secara umum melalui anakan (sucker) dan belahan bonggol (corm), namun bibit yang dihasilkan dengan cara ini menghasilkan sedikit anakan dan membutuhkan waktu relatif lama,  pertumbuhan tidak seragam sehingga penanaman skala besar akan sulit dilakukan. Perbanyakan melalui kultur jaringan pada pisang barangan telah dilakukan, hingga diperoleh bibit bermutu baik (seragam dan bebas patogen) dalam jumlah lebih banyak dan cepat. Keberhasilan menginisiasi pembentukan kalus dan tunas merupakan langkah awal untuk menghasilkan planlet dengan multiplikasi yang tinggi. Penelitian ini dilaksanakan di laboratorium kultur jaringan  UPT. Balai Benih Induk Gedung Johor Dinas Pertanian Provinsi Sumatera Utara. Tujuan penelitian untuk mengetahui pengaruh beberapa konsentrasi ZPT: (1). NAA (Naphthaleneacetic acid) dan BAP (Benzylamino purin) terhadap pertumbuhan eksplan pisang barangan secara kultur in vitro. (2). BA (Benzyl Adenin)  dan IBA (Indole Butyric Acid). Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) Faktorial. Hasil penelitian menunjukkan bahwa pengaruh konsentrasi NAA dan BAP; BA dan IBA terhadap pertumbuhan dan perkembangan eksplan tampak terutama dimulai pada minggu ke-2 setelah aplikasi hingga minggu ke-12. Konsentrasi BAP dan kombinasi konsentrasi NAA dan BAP serta konsentrasi BA dn IBA dan interaksinya tidak berpengaruh nyata terhadap persentase tumbuh, jumlah tunas, panjang tunas, dan bobot tunas
Meningkatkan Kemampuan Motorik Kasar Anak Berkebutuhan Khusus Melalui Kegiatan Melempar Bola Pada Olahraga Boccia Dengan Pendekatan Hots Di SMALB – D1 YPAC Surakarta
Authors: Gandes Luwes Ulwa Humairok
Published: February 2021

Penelitian ini bertujuan untuk mengetahui apakah penggunaan media olahraga Boccia dapat meningkatkan kemampuan motorik kasar melempar bola di SMALB – D1 YPAC Surakarta. Penelitian ini merupakan penelitian tindakan kelas dengan analisis deskriptif kolaboratif. Penelitian dilaksanakan di SMALB – D1 YPAC Surakarta dengan subyek berjumlah 5 siswa yang terdiri dari 4 laki-laki dan 2 perempuan. Pada kemampuan awal terlihat 1 siswa yang melakukan gerak melempar bola. Pada Siklus I sudah mengalami kemajuan menjadi 3 siswa melempar bola dengan baik. pada Siklus II tingkat keaktifan siswa terpenuhi. Dengan diberikan media olahraga bocid, siswa sudah aktif mengikuti kegiatan melempar bola, sehingga indikator keaktifan siswa telah terpenuhi
Efektivitas Penerapan Penggunaan Laboratorium Riil Dalam Tatanan Pembelajaran Berbasis Masalah Terhadap Keterampilan Proses Sains Siswa Kelas XI SMA Negeri 6 Pematangsiantar
Authors: Purba Sumarny Tridelpina , Siboro Thiur Dianti
Published: February 2021

Penelitian ini bertujuan untuk mengetahui evektivitas penerapan penggunaan laboratorium riil dalam tatanan pembelajaran berbasis masalah terhadap keterampilan proses sains siswa di SMA Negeri 6 Pematangsiantar. Metode penelitian yang digunakan metode penelitian tindakan kelas yang mencakup Siklus I dan Siklus II dengan menggunakan Laboratorium Riil dalam tatanan pembelajaran berbasis masalah. Pengumpulan data terdiri dari lembar observasi, LKS, soal pretest, dan soal postest. Teknik pengambilan data adalah dengan observasi, dan tes. Dari hasil penelitian diperoleh bahwa keterampilan proses sains yang diperoleh pada penelitian ini, berada dikategori “cukup” dan “baik”. Kemudian rata-rata peningkatan hasil belajar dengan menggunakan model pebelajaran berbasis masalah yang memiliki rentang perbedaan yang besar dari siklus I sampai siklus II dimana dapat dikategorikan dari sedang menjadi tinggi. Dari hasil penelitian di atas, dapat disimpulkan bahwa pembelajaran biologi dengan penerapan penggunaan laboratorium rill dalam tatanan model pembelajaran berbasis masalah mampu meningkatkan keterampilan proses sains siswa pada kelas XI SMA Negeri 6 Pematangsiantar
Perbedaan Pertumbuhan Fisik dan Perkembangan Motorik Anak Lahir Normal dan Sectiocaesarea (Studi Kasus Anak Usia Toodler 1-3 Tahun) di Kecamatan Biru-Biru Tahun 2019
Authors: Lubis Fithri Handayani , Sembiring Bunga Mari
Published: February 2021

Latar Belakang: Pertumbuhan fisik dan perkembangan motorik anak dipengaruhi oleh banyak faktor salah satunya adalah proses persalinan. Proses persalinan dibedakan menjadi 2 yaitu proses persalinan spontan dan sectio caesarea. Perkembangan awal maturasi otak pada bayi dipengaruhi oleh mekanisme reflek diantaranya reflek primitif dalam kandungan, reflek lahir, reflek primitif setelah lahir dan reflek natural. Proses persalinan spontan menyebabkan bayi secara aktif mengalami reflek lahir, sedangkan bayi yang dilahirkan secara sectio caesarea tidak mengalami reflek lahir. Tujuan: Menganalisis perbedaan pertumbuhan fisik dan perkembangan motorik anak lahir normal dan sectio caesarea. Metode: Quasi Experiment dengan desain kasus kontrol terhadap 45 anak usia toodler, pada kelompok kasus dan 45 anak usia toodler. Hasil: Berdasarkan hasil analisis dengan uji Mann-Whitney  diketahui bahwa hasil nilai Z hitung variabel Perkembangan -1,627 dengan nilai sig. 0,104 dan pada variabel Pertumbuhan menunjukkan nilai Z hitung -2,852 dengan nilai sig. 0,003. Simpulan: Tidak ada perbedaan Perkembangan Motorik Anak Lahir Normal dan Sectiocaesarea dan ada perbedaan pertumbuhan Fisik Anak Lahir Normal dan Sectiocaesarea
Analisis Faktor Resiko Kejadian Infertilitas Pada Perawat di RSU Sembiring
Authors: Panjaitan Ribka Flora , Manurung Evalina
Published: February 2021

Latar Belakang: Infertilitas atau Infekunditas merupakan suatu penyakit pada sistem reproduksi yang dapat didefinisikan sebagai kegagalan untuk mencapai kehamilan klinis setelah 12 bulan atau lebih berhubungan seksual tanpa penggunaan alat kontrasepsi. Infertilitas pada pasangan usia subur di seluruh dunia diperkirakan sekitar 50-80 juta. Di Indonesia, 10-15% jumlah penduduk mengalami infertilitas. Prevalensi wanita usia subur yang mengalami infertilitas diperkirakan mencapai 6,08%. Prevalensi infertilitas tertinggi terdapat pada usia 20-24 tahun sebanyak 21,3%. Sedangkan prevalensi infertilitas terendah pada usia 40-44 tahun yaitu 3,3%. Penelitian ini bertujuan untuk menganalisis faktor resiko kejadian Infertilitas pada Perawat di RSU. Sembiring dengan variabel penelitian (Umur, Masa Kerja, Status Gizi, Infeksi Organ Reproduksi dan Paparan rokok). Rancangan penelitian yang akan digunakan adalah crossectional study dengan pendekatan retrospektif. Pengumpulan data akan dilakukan melalui wawancara yang berpedoman pada kuesioner yang telah memenuhi unsur validitas dan reliabilitas dan pengukuran Body Mass Index (BMI). Sampel dalam penelitian ini berjumlah 70 orang Perawat di RSU. Sembiring, Delitua, Deli Serdang. Analisis data secara univariat, bivariat dan multivariate. Hasil aanalisis statistik pada tahapan Multivariat menunjukkan bahwa terdapat 3 variabel yang berhubungan dengan kejadian Infertilitas pada perawat di RSU. Sembiring yaitu Masa Kerja dengan nilai sig.0,006, Status Gizi dengan nilai sig.0,029 dan Infeksi pada Organ Reproduksi dengan nilai sig. 0,003.
Studies on Synthesis, Characterization and Transport Properties of Ta2O5 Doped Polyaniline Composites
Authors: Nagajyoti  , Sangshetty Kalayne
Published: February 2021

Polyaniline (PANI) and PANI/Ta2O5 composite samples were prepared using chemical oxidative polymerization technique in the presence of hydrochloric acid (HCl) at room temperature. The effect of Ta2O5 on surface morphology and structural changes have been investigated and evaluated by X-ray diffraction (XRD) and scanning electron microscope (SEM) techniques. The XRD pattern of the PANI and PANI/Ta2O5 confirm the formation of PANI and its composite. The average crystallite size of the PANI is 2.86 nm which is increased to 46.80 nm when Ta2O5 was doped in the PANI matrix. SEM micrographs of the composite confirm the morphological changes in the composite materials. In the electrical conductivity studies, ac conductivity was carried as function of frequency and dc conductivity was studied as a function of temperature. Further to describe the dielectric properties of the PANI and composite, dielectric constant and dielectric loss was studied as a function of frequency.
Violencia intra/extra-familiar en personas mayores
Authors: Kárpava Alena , Martínez Heredia Nazaret
Published: February 2021

El presente artículo parte de un trabajo de investigación cuyas ideas fueron expuestas en el XXVII Congreso Internacional de Pedagogía Social. La institucionalización del cuidado de las personas mayores dependientes debería contribuir al descenso de los casos de violencia en su entorno, al incremento de su autonomía personal, a su participación, al fomento del bienestar en la relación entre la persona mayor y sus cuidadores. No obstante, la práctica demuestra aparición de nuevas manifestaciones de violencia, entre la persona cuidadora y dependiente, mujer nativa e inmigrante, familiar directo y cuidador(a) contratado(a), nivel económico. Con este estudio, de metodología mixta, se pretende visualizar las manifestaciones de violencia, su incidencia, tipología y grado de su autopercepción por las personas mayores, con el fin de elaborar un proyecto de intervención del personal educador-cuidador externo al domicilio de las personas mayores. El análisis de los datos fue realizado gracias a los programas informáticos Atlas.ti, para los datos cualitativos, y SPSS, versión 23.0, en lo referente a los datos cuantitativos. Como proyección futura proponemos realizar un segundo artículo diseñando materiales específicos para la impartición, en el servicio de atención de las personas mayores, talleres educativos de prevención, mediación y transformación de los conflictos interpersonales e interfamiliares.