bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Water Resource Management: Integrating MODSIM Simulation with SWOT-QSPM Analysis
Authors: Zeinali Hasti , Jozi Seyed Ali , Malmasi Saeid , Rezaian Sahar
Published: November 2024

The reduction in atmospheric precipitation, along with the growing gap between water resources and consumption, especially in agriculture, has disrupted the water balance of the Urmia Lake watershed. In this study, the MODSIM model was used as a decision-support tool to simulate three scenarios examining the status of water resources and uses in the Urmia Basin (S), a 40% reduction in agricultural uses (S1), domestic wastewater treatment and return of effluent to the water resources of the Urmia Lake watershed (S2), and a 45% increase in drinking and industrial uses due to population growth and a 245% increase in agricultural uses due to agricultural development (S3) until the year 2041. Subsequently, the SWOT and QSPM models were utilized to analyze and prioritize strategies. The findings indicated that the monthly volumes of water inflow and stored in Urmia Lake in scenarios S1, S2, and S3 would respectively be 22.8%, 8.4%, -38%, 14.3%, 5.3%, and − 42.9%. Meanwhile, the average monthly evaporation volumes will respectively be 17.5%, 5.9%, and − 19.8%. Based on these results, scenario S1 is identified as the optimal management strategy. The findings indicated that, based on the IFE score of 2.986 and EFE score of 3.068 in the SWOT matrix, there is a necessity for conservative strategies (WO) to exploit internal opportunities to compensate for weaknesses. In the QSPM model, among the five presented conservative strategies, the most crucial strategy identified was "crop pattern modification and use of high-yield, water-efficient cultivars through demand management programs," with a score of 5.61. The results of this study can be utilized to envisage an appropriate outlook on the future state of the watershed in order to adopt decision-making policies and planning toward the optimal use of water resources.
PAPP-A protein diagnostic and prognostic significance in acute coronary syndromes without persistent ST-T-segment elevation.
Authors: Różycka-Kosmalska Monika , Frankowski Rafał , Pękala-Wojciechowska Anna , Sipowicz Kasper , Pietras Tadeusz , Kosmalski Marcin
Published: November 2024

There are ongoing attempts to find a reliable, highly sensitive and specific early indicator of myocardial ischemia. Recently, a potential new function for the “non-pregnancy” related PAPP-A protein has been reported in many papers, including that the protein could be used in diagnosing heart conditions. Hence, our study aimed to determine the diagnostic and prognostic significance of PAPP-A protein in individuals diagnosed with Non ST-Elevation Acute Coronary Syndromes (NSTE-ACS). The study comprised a 100 consecutive patients (68 males and 32 females), aged from 42 to 83 years (mean age: 64.2 years). We assessed PAPP-A protein levels, anthropometric measurements, basic laboratory tests, ECG recordings, and coronary angiography for each patient. The participants were subsequently divided into two groups: Non ST Elevation Myocardial Infarction (NSTEMI, n = 74) or Unstable Angina (UA, n = 25). The levels of PAPP-A protein in patients with NSTEMI were slightly higher than those in patients with UA, but the difference was not statistically significant (7.93 ± 6.35mIU/l vs. 6.52 ± 5.45mIU/l, p = 0.253). Higher levels of PAPP-A protein (≥ 5.83mIU/l) were found to be linked to a greater risk of NSTEMI (OR = 1.37; 95%CI: 0.56–3.36), although with less accuracy compared to the initial measurement of troponin T (cTnT) in the identification of cases. After 12 months, there was a significant correlation between the amount of labeled PAPP-A protein and the likelihood of experiencing acute myocardial infarction, cardiovascular death, and the necessity for unplanned coronary angiography (UCA). The diagnostic utility of PAPP-A protein in NSTE-ACS is limited, both in the NSTEMI and UA patient groups. However, its measurement can be used to estimate the annual risk for these groups of patients.
Emergence and Characterization of Mixed Candida auris Strain Infections in China
Authors: Du Han , Huang Yanfeng , Guo Penghao , Liang Weihong , Zheng Tianhong , Guan Zhangyue , Bing Jian , Chu Haiqing , Huang Guanghua
Published: November 2024

Purpose The multidrug-resistant fungal pathogen Candida auris poses an increasing global health threat due to its high transmissibility and persistence in healthcare environments. We identified five cases of mixed C. auris-strain infections in China and investigated the genetic and biological diversity of the isolates to explore the potential causes of C. auris infection.
Methods C. auris isolates from 5 infection cases were distinguished by colony morphology and verified by D1/D2-ITS alignment. Phylogenetic and genomic diversity analysis of all isolates were conducted using whole genome sequences. Comparative biological analysis of all isolates, including cellular and colony morphology, antifungal susceptibility, biofilm formation, SAP activity, and both in vitro and in vivo survival capabilities were performed.
Results Five cases of mixed C. auris-strain infections in China were identified. Comparative genomic analysis revealed these infections involved strains from two distinct genetic clades (I and III) or strains from the same clade but with genetic alterations. Comparative biological analysis demonstrated the strains from mixed infections exhibit differences in several key aspects, including colony morphology, biofilm formation, SAP activity, and both in vitro and in vivo survival capabilities.
Conclusion Comparative analyses revealed notable differences in biofilm formation, environmental survival, and secretion of virulence factors between the co-infecting strains of C. auris. These biological and genetic disparities may present significant challenges for the diagnosis and treatment of C. auris infections, as strains with different genetic backgrounds may exhibit varying abilities to colonize host or environmental niches.
Cecal volvulus on top of Ladd’s band: a case report and review of literature
Authors: Ayyad Mohamed Salah , Alqasaby Abdallah , Rezk Mohamed , Abonosier Ahmed , Khalid Shaimaa , Azam Ahmed
Published: November 2024

Background:
Cecal volvulus is a rare cause of bowel obstruction that represents a challenge in both diagnosis and management. This unique form of closed-loop obstruction occurs due to a twist in the mesentery with subsequent dilatation of the cecum. As a result of the massive distension of the large bowel, many radiologists find it difficult to recognise the signs suggestive of cecal volvulus. In this article, we highlight the role of imaging in the management of this form of bowel obstruction.
Case presentation:
A thirty-six-year-old female patient presented to our emergency department with symptoms of acute abdomen. Imaging revealed a massively dilated large bowel loop in an abnormal distribution in the centre of the abdomen with a whirlpool in the mesentery. Cecal volvulus was suspected. Surgical exploration confirmed the diagnosis and an abnormal band connected to the cecum (Ladd’s band) was also identified. The patient underwent division of the band with ileo-transverse colostomy. Unfortunately, the patient passed away due to cardiorespiratory failure two days after the operation.
Conclusions:
The radiologist should always consider cecal volvulus in the differential diagnosis of closed-loop obstruction particularly at a young age. A hypermobile cecum on imaging may suggest Ladd's band, even without signs of malrotation. All relevant items should be addressed when reporting bowel obstruction cases.
Design optimization of semiconductor manufacturing equipment using a novel multi-fidelity surrogate modeling approach
Authors: Wang Bingran , Kim Min Sung , Yoon Taewoong , Lee Dasom , Kim Byeong-Sang , Sung Dougyong , Hwang John T.
Published: November 2024

Careful design of semiconductor manufacturing equipment is crucial for ensuring the performance, yield, and reliability of semiconductor devices. Despite this, numerical optimization methods are seldom applied to optimize the design of such equipment due to the difficulty of obtaining accurate simulation models. In this paper, we address a practical and industrially relevant electrostatic chuck (ESC) design optimization problem by proposing a novel multi-fidelity surrogate modeling approach. The optimization aims to improve the temperature uniformity of the wafer during the etching process by adjusting seven parameters associated with the coolant path and embossing. Our approach combines low-fidelity (LF) and high-fidelity (HF) simulation data to efficiently predict spatial-field quantities, even with a limited number of data points. We use proper orthogonal decomposition (POD) to project the spatially interpolated HF and LF field data onto a shared latent space, followed by the construction of a multi-fidelity kriging model to predict the latent variables of the HF output field. In the ESC design problem, with hundreds or fewer data, our approach achieves a more than 10% reduction in prediction error compared to using kriging models with only HF or LF data. Additionally, in the ESC optimization problem, our proposed method yields better solutions with improvements in all of the quantities of interest, while requiring 20% less data generation cost compared to the HF surrogate modeling approach.
Infection Rate of External Ventricular Drain In Neurosurgical Patients : A single center study
Authors: Bashareef Akram , Al-Olama Mohammad
Published: November 2024

Background: External ventricular drain (EVD) is a common neurosurgical procedure, associated with high rates of infection and consequent morbidity and mortality.
Objective: The aim of the study is to analyze the EVD related infections, the risk factors, management and prevention.
Methods: This is a retrospective analysis from January 2011 to December 2013; a total of 160 patients having EVD inserted, Sixteen patients had a primary Cerebrospinal fluid (CSF) infection and were excluded from the further analyzes of the secondary EVD infections. Hence, 144 patients were included in the study. Sets of clinical parameters were analyzed in these cases to verify the EVD infection rate and the related causes, risk factors, causative agents and outcome.
Results: A total of 160 patients, 182 EVD procedures, and 1016 catheter-days were evaluated. The EVD-associated CSF infection rate was 18.8%. The most common diagnosis required EVD was strokes (59.7%). (44%) of the infections were caused by Gram-negative organisms. All of the patients received antibiotic prophylaxis.
Conclusion: It has been found that there are a relative high percentage of EVD-related infections. After different analysis of the existing data we found that manipulation of the EVD and the duration of the drainage were the most risk factors for the EVD infections. A new EVD protocol has been proposed in our hospital to minimize such infections.
The swarmable magnetic-driven nanorobots for facilitating trans- intestinal mucosal delivery of oral vaccines to enhance mucosal and systemic immune responses
Authors: Huang Linghong , Sun Xinyuan , Zhang Quan , Long Jun , Chen Xuewu , Dong Renfeng , Liu Zonghua , Guo Zhong
Published: November 2024

The continuous secretion of mucus by the intestinal mucosa and the intestinal motility combine to limit the absorption of orally administered vaccines. To extend the residence time of vaccines within the gastrointestinal tract and to improve their mucosal transit, we have developed a technology capable of swiftly and actively traversing the intestinal mucus barrier. In this study, we synthesized a biodegradable magnetic driven nanorobot (MNC@CaMn) loaded with antigen and constructed a magnetic driven nanorobot vaccine delivery platform. Under the precise regulation of the magnetic field, the residence time of the vaccines in the intestine was significantly prolonged, and the vaccine exhibited a swarming motility that could rapidly converge and cross the intestinal mucus barrier in a targeted manner, thus greatly facilitating antigen delivery and presentation and significantly activating CD8 + T lymphocytes. In addition, the rough surface of the nanorobot ensured stable antigen loading, while the Mn2+ in the particles was able to stimulate efficient mucosal and systemic immune responses due to its excellent adjuvant effect. The magnetic driven nanorobot vaccine delivery system constructed in this study provides a new strategy for the development of efficient oral and mucosal vaccines.
Pre and Post -Operative Patient's Education on Trans-Tibial Amputee in Sudan.
Authors: Bleedy Nermeen , Abdelnour Hassan , Hawari Norhan , Khan Muslim , Mortada Omnia , Yagoub Sulwan , Ahmed Abdelrazak , Abbas Amany
Published: November 2024

Background
Worldwide, limb amputation is a very common procedure that is indicated after severe complications of diseases and after major physical traumas which cause a damage that is untreatable. Studies showed high prevalence of amputation in Sudan as a result of Diabetic. The most common type of major lower limb amputations is called Trans-tibial or below knee amputation. Any patient who undergoes an amputation will need thorough educational program to know more about his/her condition, avoid complications, and be able to return to his/her functional and normal life before the amputation.
Aim
The aim of this study was to determine the effect of pre- and postoperative patient education on preventing knee flexion contractures in trans-tibial amputation patients in selected centers in Khartoum state.
Method
A quantitative, descriptive, cross-sectional survey was used in this study. The data was collected using a self-administered questionnaire. A total of fifty participants from four facilities have participated in the study. The data were analyzed using Statistical Package for the Social Sciences (SPSS) Version 21
Result
More than half of the participants who received patient education, did not have any complications and only 28% of them had complications. There were 42% of study participants came from outside Khartoum to seek Trans-tibial amputation rehabilitation services. There were 68% of participants received education from their physiotherapists.
Conclusion
There are a shortage in Trans-tibial amputation rehabilitation services outside Khartoum city. The study concluded that the pre- and postoperative patient education is important as it can decrease the number and severity of complications an amputee might have after the surgery.
Recommendations: Pre- and post-operative Patient education must be part of the rehabilitation protocol and awareness about it should be required for patient and the rehabilitation team.
Ações para Captação de Mulheres na Realização da Coleta do Exame Papanicolau no Âmbito da Estratégia Saúde da Família
Authors: Bier Luis Henrique da Silva , Afonso Pollyana de Carvalho , Alves Jonioma Evangelista
Published: November 2024

O câncer de colo do útero vem sendo considerado um transtorno para saúde pública em países em desenvolvimento manifestando grandes taxas de mortalidade entre mulheres de nível socioeconômico reduzido e em períodos reprodutivos de suas vidas. Os profissiopnais da ESF devem trabalhar nas ações de busca ativa e educação em saúde na questão da temática de prevenção do câncer de colo de útero. As mulheres elegíveis para coleta de preventivo devem entender que a realização desse exame é agarantia de que, mesmo que venha a desenvolver a doença, as chances de cura serão maiores, considerando as caraccteriscicas da patologia O objetivo desse estudo foi identificar as ações para a captação de mulheres elegíveis para coleta de exame preventivo no âmbito da Estratégia saúde da Família. Para tanto utilizou-se como metodologia a revisão de literatura com critério de inclusão, artigos, teses e dissertações publicados na íntegra nas bases de dados selecionadas e publicados nos últimos 5 anos no idioma português. O acesso aos serviços de saúde é fator determinante para o diagnóstico do câncer do colo do útero em tempo oportuno. Atrasos no diagnóstico levam a diagnósticos em fases mais avançadas. Nesse aspecto, as ações de rastreamento para o câncer de colo uterino têm papel importante, não apenas na redução da incidência da doença, mas também na redução da mortalidade por propiciarem diagnóstico precoce. A busca ativa, ações e palestras se mostram um fator importante para essa cobertura do exame Papanicolau.
Students as creators of contexts for learning algorithms: how collaborative context design contributes to a wide range of learning outcomes
Authors: Nijenhuis-Voogt Jacqueline , Bayram-Jacobs Durdane , Meijer Paulien , Barendsen Erik
Published: November 2024

A context-based approach to education aims to improve students’ meaningful learning and uses authentic situations in which scientific concepts are applied. The use of contexts may contribute to the learning of abstract concepts such as algorithms. The selection of appropriate contexts, however, is challenging for teachers. It is therefore interesting to examine whether students can play an active role in the conception of such contexts and how designing contexts may contribute to student learning. As a case study, we investigated students' design of contexts for learning algorithms in upper secondary education. We developed lessons in which students collaboratively designed contexts and then reflected individually on all contexts proposed. At the end of these lessons, students completed a learner report. The students' design of contexts provided a remarkably wide range of learning outcomes. Students not only reported to have learned more about the lesson topic (algorithmic concepts and the application of these), but the learning reports also reflected learning about the process (learning with contexts, designing contexts, and collaboration). Our findings suggest that designing contexts contributes to active learning. The results of this study may serve as recommendations for future research concerning the role of students in designing contexts.
A comprehensive approach to building a continuous hydrologic model with Soil Moisture Accounting using Earth Observation data
Authors: Thomopoulou Vasiliki , Iliopoulou Theano , Kossieris Panagiotis , Bariamis George , Tsoukalas Ioannis , Efstratiadis Andreas , Makropoulos Christos
Published: November 2024

In recent years, both availability and interest in Earth Observations (EO) have increased due to their ability to provide information with extensive spatial coverage, which is valuable for data-scarce regions. This study provides a roadmap to exploit EO/satellite data (EO-based model) for continuous hydrological simulation using the Hydrologic Engineering Center–Hydrologic Modelling System model with a soil moisture accounting (SMA) component. As a case study, we consider the Boeotikos Kephisos River basin, in Greece. The SMA component is calibrated using the HiHydroSoils dataset, to map its parameters to the regionally varying soil hydraulic properties and a comparison is made to an alternative parameterization, following the standard literature approach (literature-based model). The effectiveness of satellite data in enhancing model performance is further assessed, by comparing three different satellite precipitation datasets, as model drivers, and by using satellite-based soil moisture for model initialization. The discussion extends to the potential for integration of EO/satellite data at the operational level, by simulating a significant precipitation event. Yet, the most promising result pertains to the opportunity to exploit satellite-derived estimates of soil hydraulic properties to base the calibration of the data-intensive SMA scheme, with the EO-based model significantly outperforming the literature-based model parameterization.
A comprehensive approach to an urban water reuse system to meet irrigation demand and conserve water: City of Cape Coral, FL, USA
Authors: Pearson Jeffery , Tsegaye Seneshaw , Missimer Thomas M.
Published: November 2024

Maximizing the reuse of domestic wastewater is a critical objective, spurred by the pressing need to avoid water loss, reduce environmental discharges, and manage irrigation water demand. In the City of Cape Coral (FL, USA), thousands of old-fashioned and inefficient irrigation systems have been installed over the past 50 years. The city has adopted year-round external water use restrictions, but demands continue to increase. In 2020, peak 24-h irrigation water demands exceeded 177,914 m3. In response to recurrent dry seasons and growing demand over the past 20 years, the city has diversified its water resources. The city uses brackish groundwater with reverse osmosis treatment to produce drinking water and reuses 100% of its wastewater effluent for irrigation by blending the treated wastewater with fresh water from 483 km of freshwater canals. To promote efficient irrigation water use among consumers, a new approach has been adopted to automate private irrigation systems. The Environmental Resource Assessment and Management System Integrated Urban Water Model was used to simulate water management scenarios. The simulation showed that increasing automatic irrigation efficiency can save millions of cubic meters of irrigation water and help the city meet the future build-out peak-day demand of 219,758 m3/d, as estimated by the Blaney–Criddle method.
CONSTRUÇÃO AUDIOVISUAL DOS MEDOS EM TEMPOS DE PANDEMIA COVID-19 NO BRASIL
Authors: Oliveira Normandia Danton , Miucci Ferraresi de Barros Carla
Published: November 2024

O medo em perspectiva histórica e cotidiana denota reflexões, enunciações e expressões acerca de diferentes e diversificadas temáticas e realidades. Nesse cenário, priorizando o Brasil no período da pandemia da covid-19, o audiovisual e suas respectivas produções, exemplificadas na 3° edição do Festival Curta (C)errado – “O medo nosso de cada dia” (2021), contribuem para uma necessária discussão que acarreta possibilidades, proporções e limites em torno do medo e sua intrínseca relação para com o homem e a humanidade em movimento.
GRÉCIA DE HERÓDOTO:
Authors: Lopes Jahan Natanael Domingos
Published: November 2024

Para desvelar, através da arqueologia foucaultiana, o saber discursivo de Heródoto(484 – 425 a.C.), visou-se a um estudo, entre identidades e diferenças, de sua obraHistória. Disso, parte-se do método arqueológico ao saber geográfico. No mundogrego, delimitaram-se duas camadas de pensamento: a camada egoica, entre heroispor Homero e deuses por Hesíodo e a camada de alteridade, entre a guerra greco-persa de Heródoto e a guerra do Peloponeso de Tucídides. Aliás, entende-se queHeródoto não existe senão à medida da gramática, da semântica, do léxico e doconteúdo material de sua camada histórica. A Grécia, portanto, existe comodiscurso da situação contemporânea do autor pelo encontro de si no Outro e doOutro em si. Assim, abre-se o tempo grego em uma geografia arqueológica.
REPRESENTAÇÃO NOS DOCUMENTÁRIOS SOBRE RAMON LLULL:
Authors: Vinícius Medeiros de Santana Márcio
Published: November 2024

O presente artigo corresponde aos resultados obtidos durante a pesquisa queocorreu de 2022 e 2023, no Programa Institucional de Bolsas de Iniciação Científica (PIBIC), vinculado à Universidade XXXX (XXXX), cujo projeto buscou examinar e interpretar os primeiros documentários que tinham por objetivo contar a história do pensador maiorquino Ramon Llull (c. 1232-1316). Portanto, tendo noção dessecenário de disputa que é o campo das representações, foi possível por meio dessa pesquisa observar, nas produções audiovisuais, nos documentários, a evolução das produções que retratam a persona de Llull, o desenvolvimento de suas inúmeras facetas, seus objetivos latentes e a relação entre os documentários com a época em que foram produzidos.
LIMITES ENTRE A HISTÓRIA PÚBLICA E A HISTÓRIA DIGITAL:
Authors: Silva João Pedro Ferreira da
Published: November 2024

O presente trabalho visa problematizar a produção de História para a internet, especialmente na plataforma Tiktok, refletindo sobre  qual o papel da História Pública na descentralização das narrativas sobre o passado de espaços acadêmicos e escolares. Visando compreender a complexidade das redes e do processo de plataformização, pelo qual passamos no atual estágio do capitalismo (CESARINO, 2022), propomos a adoção dos Mapas das Mediações Comunicativas da Cultura, elaboradas por Martin Barbero (1997). Esta metodologia passa pela análise da complexidade de interações entre os diversos agentes culturais, a circulação de informações e a construção de significados culturais. Discorrendo sobre essa totalidade de produção desses conteúdos, apontamos algumas demarcações historiográficas e tecnológicas como centrais para a compreensão desse novo formato de divulgação da História, seus limites e consequentemente qual o papel da disciplina para pensar horizontes de superação.
Determinação da toxicidade do gossipol em folículos ovarianos de ovelhas
Authors:   , Câmara Antônio Carlos Lopes
Published: November 2024

O gossipol é um composto polifenólico produzido pelas glândulas de pigmento do algodoeiro (Gossypium spp.); apresentando ação deletéria comprovada sobre a espermatogênese, ciclo estral de roedores, esteroidogênese nas células da granulosa em suínos, interrupção precoce da gestação e desenvolvimento embrionário inicial. No entanto, os efeitos sobre os ovários de ovelhas ainda não havia sido estudado. O presente estudo foi dividido em duas etapas: determinar o efeito in vitro e in vivo do gossipol sobre folículos ovarianos de ovelhas. Na primeira etapa, oito fragmentos ovarianos de cada animal foram cultivados em Meio α-MEM suplementado e submetidas a cultivo em três concentrações de gossipol-ácido acético (5, 10 e 20 μg/mL) por períodos de 24h e sete dias. A ação do gossipol in vitro proporcionou redução significativa no número de folículos viáveis em todos os estágios de desenvolvimento folicular; e aumento significativo no número de folículos atrésicos após 24h e sete dias de cultivo (p < 0,01). Neste último também foi notório a ausência de folículos antrais viáveis, e, os folículos primordiais apresentaram viabilidade inferior a 50%. Na segunda etapa, foram utilizadas doze ovelhas mestiças, que foram aleatoriamente separadas em dois grupos e alimentadas com rações contendo torta de algodão ou não (grupo controle). A ração foi oferecida na proporção de 1,5% do peso vivo do animal por 63 dias. As concentrações de gossipol total e livre na torta de algodão foram 3,28 mg/g e 0,11 mg/g, respectivamente. Durante todo o período experimental, nenhum animal apresentou qualquer sinal clínico de intoxicação. Não houve interferência sobre as concentrações de progesterona, peso, ganho em peso e medidas ovarianas. Apenas alterações ocasionais sobre a citologia vaginal, parâmetros hematológicos e bioquímicos foram evidenciadas. Entretanto, o tratamento com gossipol foi responsável por redução significante no número de folículos ovarianos viáveis (20,6% nas ovelhas tratadas e 65,1% no grupo controle) e aumento significante no número de folículos atrésicos (79,4% nas ovelhas tratadas e 34,9% no grupo controle), com interferência em todas as fases de desenvolvimento folicular (p < 0,01). Em conclusão, o gossipol promove danos diretos aos folículos ovarianos de ovelhas, resultando em aumento na proporção de folículos atrésicos e redução dos folículos viáveis tanto in vitro como in vivo
Moscas-das-frutas (Diptera: Tephritidae) e seus Parasitóides (Hymenoptera: Braconidae), em Pomares Domésticos, nos Municípios de Apodi e Baraúna, Rio Grande do Norte
Authors:   , Costa Gleider Maria de Menezes
Published: November 2024

O Estado do Rio Grande do Norte (RN) é um dos maiores produtores de frutas tropicais, dispondo de condições edafoclimáticas adequadas para o desenvolvimento dessa atividade em grande escala. Diante do impacto negativo que as moscas-das-frutas representam para o agronegócio, faz-se necessário que estudos sobre essa praga sejam realizados nas regiões com potencial frutícula, como também é crucial o conhecimento dos parasitóides existentes na região, com vistas ao planejamento estratégico de controle biológico e manejo integrado de pragas. Este trabalho foi realizado nos municípios de Apodi e Baraúna, localizados na região semiárida do RN. Teve como objetivos identificar as espécies de moscas-das-frutas, o padrão de distribuição e as relações com plantas hospedeiras e seus parasitóides associados. Após três anos de coletas, obteve-se 15.608 frutos e 9.961 tefritídeos, sendo 4.953 exemplares de Anastrepha e 5.008 de Ceratitis capitata. As espécies de Anastrepha presentes nos frutos individualizados foram Anastrepha zenildae (35,82%), Anastrepha sororcula (8,19%), Anastrepha obliqua (4,45%), Anastrepha pickeli (0,74%) e C. capitata (50,8%). Considerando a presença simultânea de moscas-das-frutas e parasitóides em um mesmo fruto, encontrou-se em cajá Doryctobracon areolatus associado com A. obliqua; em goiabas, houve associação do parasitóide com A. sororcula e A. zenildae; em juá, a associação foi observada apenas com A. zenildae. O único parasitóide encontrado foi o D. areolatus. O índice de parasitismo total encontrado foi de 4%, válido apenas para Anastrepha, pois não se constatou associação de D. areolatus com C. capitata em um mesmo fruto. O hospedeiro cajá apresentou o maior índice de parasitismo natural (19%). A análise de regressão logística indica que o tamanho do fruto não influencia a condição de ser ou não infestado. Os resultados das regressões lineares simples indicam que, de modo geral, o peso dos frutos não determina o número de pupários. As correlações entre os fatores meteorológicos e os fatores bióticos apontam que apenas a pluviosidade afeta negativamente a porcentagem de frutos infestados
Plant-Derived Antidiabetic Agent: A Green Prevention Strategy
Authors: Kumar Awadhesh , Mishra Ruby , Ved Akash , Shukla Karuna Shanker , Kashyap Monu Kumar , Tiwari Ved Prakash , Nigam Amit Kumar
Published: November 2024

One component of metabolic syndrome is diabetes mellitus. In recent years, the prevalence
of diabetes has increased. Drugs produced chemically are used to reduce the negative effects
of diabetes mellitus and its repercussions, which include weight gain, gastrointestinal problems,
and heart failure. However, medicinal plants may provide an accurate source of drugs that combat
diabetes. This paper aims to identify the potential advantages of any plant matrix. Because they
are less costly and have minimal or no side effects, restricting one's diet, exercising, and using
plant-based antidiabetic substances are all recommended as effective ways to cure diabetes. This
review centers on the bioactive components of antidiabetic plants, their chemical Characterization,
and plant-based diets to manage diabetes. Much scientific information has been discovered regarding
the plant-based product's mode of action. This article's objective is to highlight anti-diabetic
plants and bioactive compounds produced from plants that offer anti-diabetic properties. Additionally,
it gives researchers information that could be used to develop new tactics, such as locating effective
bioactive compounds to facilitate the control of diabetes.
Flaxseed Oil: Safeguarding Neurological Health through Apoptosis and Oxidative Damage Defense
Authors: Mishra Devendra Kumar , Awasthi Himani , Srivastava Dipti , Fatima Zeeshan , Mohapatra Lucy
Published: November 2024

:

The present study aims to investigate the neuroprotective properties of flaxseed oil (FSO)
in reducing cadmium-induced neurotoxicity. The neuroprotective properties of FSO were observed
in rats by examining the expression of caspase-3 and Bcl-2 to determine the antiapoptotic capabilities
of FSO.

Methods:

Rats were given cadmium orally at a dosage of 5 mg/kg/day for 30 days, along with
flaxseed oil (FSO) at doses of 2ml/kg/day and 3ml/kg/day for the same duration. The Morris watermaze
test (MWM) and the Novel object recognition test (NOR) were performed to evaluate
learning and memory abilities. We quantified the amounts of glutathione (GSH), malondialdehyde
(MDA), nitric oxide (NO), and acetylcholinesterase inhibitory activity (AChE) in the entire brain
homogenate. Additionally, apoptosis and histopathology studies were conducted on rat brain tissues.

Results:

Intoxication with cadmium was associated with significant impairment of learning and
memory in Morris watermaze (MWM) and novel object recognition (NOR) tests. The group that
consumed Cd showed elevated levels of MDA, NO, and AChE in the brain homogenate, higher
levels of caspase-3 and Bcl-2, and decreased levels of GSH compared to the control group. Animals
treated with FSO exhibited improved learning and memory function, along with balanced levels of
oxidative and cholinergic activity in brain tissue. Additionally, levels of caspase-3 and Bcl-2 were
reduced in a similar way to the control group.

Conclusions:

The study demonstrates that flaxseed oil has positive effects by raising GSH and antiapoptotic
potential levels while reducing MDA, NO, and AChE levels in the brain. This contributes
to neuroprotection and decreases neuronal death, as supported by histopathological findings.
effect of company profitability and dividend policy on firm value PT Bukit Asam TBK
Authors: Utami Meri Amalia , Adam Mohamad , Widiyanti Marlina , Fuadah Lukluk
Published: November 2024

The purpose of this study is to obtain empirical evidence of Coal Prices, Profitability and Dividend Policy on PT Bukit Asam Tbk value listed on the Indonesia Stock Exchange. The sampling technique used purposive sampling, the research samples obtained totalled 1 company with quarterly research period from 2012-2022 so that there were 44 units of analysis. The research design was quantitative descriptive. The analysis technique in this research is multiple regression analysis method. The results showed that Coal Price has a significant positive effect, Profitability and Dividend Policy have no effect on PT Bukit Asam Tbk value. The implication of this research is that companies must pay attention to Coal Price that can affect stock price so that company value can increase.
Data Ownership in the AI-Powered Integrative Health Care Landscape
Authors: Liu Shuimei , Guo L Raymond
Published: November 2024

In the rapidly advancing landscape of artificial intelligence (AI) within integrative health care (IHC), the issue of data ownership has become pivotal. This study explores the intricate dynamics of data ownership in the context of IHC and the AI era, presenting the novel Collaborative Healthcare Data Ownership (CHDO) framework. The analysis delves into the multifaceted nature of data ownership, involving patients, providers, researchers, and AI developers, and addresses challenges such as ambiguous consent, attribution of insights, and international inconsistencies. Examining various ownership models, including privatization and communization postulates, as well as distributed access control, data trusts, and blockchain technology, the study assesses their potential and limitations. The proposed CHDO framework emphasizes shared ownership, defined access and control, and transparent governance, providing a promising avenue for responsible and collaborative AI integration in IHC. This comprehensive analysis offers valuable insights into the complex landscape of data ownership in IHC and the AI era, potentially paving the way for ethical and sustainable advancements in data-driven health care.
THE EFFECT OF CUSTOMER RELATIONSHIP MANAGEMENT DIMENSIONS ON HOTEL REPUTATION: AN EMPIRICAL STUDY
Authors: Mechta Meriem , Kebab Manel , Bouabdellah Hafidha , Mouloudj Kamel
Published: November 2024

The reputation of a hotel is of paramount importance; however, its establishment can be a complex and demanding endeavor. Accordingly, this study was conducted to investigate the impact of various dimensions of customer relationship management (CRM) on the reputation within the hotel sector. Data were gathered from 136 participants through a 23-item questionnaire utilizing a convenience sampling approach. Multiple linear regression analyses were employed to evaluate the hypotheses. The results reveal that critical dimensions such as key customer focus, knowledge management, and technology-based CRM exert a positive and significant influence on hotel reputation. Conversely, CRM organization did not demonstrate a significant effect on hotel reputation, confirming that the effectiveness of CRM lies in its practical implementation and not just its organizational framework. This study serves to enhance hotel managers' understanding of the vital role that CRM strategies play in enhancing their establishments' reputations.
Satisfacción corporal en adolescentes y su relación con el riesgo de ansiedad y depresión
Authors: Méndez-Rodríguez Marcela D. , Hernández-Sánchez Rubí , Maravillas-Estrada Angélica , Mendiola-Pastrana Indira R.
Published: November 2024

Objetivo: evaluar la asociación de satisfacción corporal y riesgo de ansiedad y depresión en adolescentes. Métodos: estudio transversal descriptivo, la población fue de 164 adolescentes de 15 a 19 años, derechohabientes del Instituto Mexicano del Seguro Social, adscritos al Hospital General de Zona con Medicina Familiar No. 8, pertenecientes a la Escuela Nacional Preparatoria No. 8 de la unam, de marzo 2023 a febrero 2024. Se aplicó el Body Shape Questionnarie para evaluar el grado de satisfacción corporal y un tamizaje de salud mental para detección de ansiedad, depresión y pánico del Instituto Mexicano del Seguro Social, de manera presencial y electrónica. Se realizó estadística descriptiva y estadística inferencial mediante el cálculo de χ2, prueba exacta de Fisher y or para estudios transversales. Un valor p<0.05 o un ic 95% fueron considerados estadísticamente significativos. Resultados: se encontró que 51.22% fue mujer y 48.78% hombre, los hombres presentaron menor insatisfacción corporal respecto a las mujeres con un resultado estadísticamente significativo con un valor p<0.001. Los adolescentes con insatisfacción corporal presentaron riesgo de ansiedad y depresión, con una asociación estadísticamente significativa en general, aunque no significativa en el caso de los hombres. Conclusión: se logró evaluar la satisfacción corporal en adolescentes y su relación con el riesgo de ansiedad y depresión, encontrando una mayor asociación en adolescentes de 17 años y en mujeres, independientemente de la edad.
Efecto de la pandemia de COVID-19 en el retraso diagnóstico de cáncer de mama
Authors: Puebla-Aldama David , García-Cervantes Nancy , Naranjo-Yela Ana M.
Published: November 2024

Objetivo: estimar el efecto de la pandemia por covid-19 en el retraso diagnóstico de pacientes con cáncer de mama (CaMa) y determinar la relación de factores sociodemográficos y clínicos con dicho retraso. Métodos: estudio de casos y controles (R-2023-3703-046) en la Unidad de Medicina Familiar No.15, Ciudad de México. Incluyó a 82 mujeres de ≥40 años con diagnóstico histopatológico de cáncer de mama, seleccionadas mediante muestreo no probabilístico por conveniencia, entre marzo 2023 y febrero 2024. Se aplicó un cuestionario sobre características sociodemográficas y clínicas, clasificando a las pacientes en periodo de pandemia (5 de abril de 2020 a 6 de mayo de 2021) y prepandemia. Las pacientes con retraso diagnóstico fueron catalogadas como casos y aquellas con diagnóstico oportuno como controles. Se realizó estadística descriptiva y análisis bivariado, estimando razones de momios con p <0.05 como estadísticamente significativo. Resultados: la mediana de edad fue de 59 años, con 47.6% clasificadas con retraso diagnóstico. Durante la pandemia, 50% de las pacientes presentaron retraso diagnóstico. La mediana de intervalo diagnóstico fue de 137 días. El dolor mamario (70.6%) y las alteraciones de la piel (100%) se asociaron a un mayor riesgo de retraso diagnóstico, así como un bi-rads 0 (85.7%). Conclusión: no se evidenció un aumento en el retraso diagnóstico durante la pandemia por covid-19. Las pacientes con dolor localizado y bi-rads 0 tuvieron mayor riesgo de retraso diagnóstico, sin diferencias en características sociodemográficas.
Tamizaje de trastornos mentales mediante el cuestionario PHQ-4 + PHQ-TP en pacientes adultos
Authors: Aguirre-Nicolás Andrea M. , Higareda-Nambo Evelyn , Cortes-Salgado Libia , Martínez-Valle Paloma G. , Mondragón-Sandoval Eva X. , Suárez-Cruz María G. , Sarmiento-Galván Dulce K. , Pérez-Patraca Aníbal de J.
Published: November 2024

Objetivo: evaluar la prevalencia de trastornos de ansiedad, depresión y ataques de pánico en pacientes de 20 a 59 años adscritos a una unidad de medicina familiar. Métodos: estudio transversal analítico. Participaron pacientes de 20 a 59 años, adscritos a la Unidad de Medicina Familiar No. 4, que acudieron al módulo prevenimss, de agosto 2023 a noviembre 2023. Se calculó tamaño de muestra con la fórmula para una proporción infinita, con una seguridad estadística de 95% y precisión de 5 a 10%, se utilizó la calculadora Open Epi, dando un total de 73 pacientes, se tomaron 100 para mayor practicidad. Instrumento de recolección de datos: Cuestionario de salud mental: detección de trastornos de ansiedad, depresión y pánico (phq-4 + phq-tp). El análisis estadístico se realizó mediante el programa spss, se incluyeron medidas de tendencia central, dispersión y pruebas estadísticas según el tipo de variable, además de un análisis bivariado con regresión logística para evaluar la relación entre trastornos mentales y el tamizaje, asimismo se calculó la prevalencia. Resultados: de una muestra de 100 pacientes tamizados en los módulos de medicina preventiva, se detectaron 11 pacientes con síntomas sugerentes de algún probable trastorno de ansiedad, depresión y/o ataque de pánico. Conclusión: actualmente una de cada 10 personas de 20 a 59 años que asisten a la Unidad de Medicina Familiar No. 4, presenta algún síntoma sugerente de un trastorno de salud mental sin tener diagnóstico ni tratamiento.
Calidad de vida en pacientes con diagnóstico de fibromialgia con atención psicológica
Authors: Gerardo-Morales Ana D. , Sánchez-Almazán Patricia , López-Delgado Mariana , Garibay-López Leticia
Published: November 2024

Objetivo: evaluar la calidad de vida en pacientes con diagnóstico de fibromialgia con atención psicológica. Métodos: Se llevó a cabo un estudio transversal descriptivo en la Unidad de Medicina Familiar No. 9. Se calculó la muestra utilizando el método para poblaciones finitas, con un intervalo de confianza de 95%, obteniendo 35 pacientes con diagnóstico de fibromialgia. Se utilizó el instrumento whoqol-bref para evaluar la calidad de vida, según los criterios de la Organización Mundial de la Salud. Resultados: se encuestó a un total de 35 pacientes del sexo femenino, edad promedio de 54.49; 54.2% recibió atención psicológica y refirió tener buena calidad de vida, 34.2% reportó una mala calidad de vida sin atención psicológica, el dominio con mayor afectación fue el físico. Conclusión: los resultados de este estudio destacan que los pacientes que reciben tratamiento especializado con atención psicológica reportan una buena calidad de vida. Esto subraya la importancia de individualizar el tratamiento y considerar diversas áreas de intervención no farmacológica.
Prevalencia de depresión en pacientes que tuvieron COVID-19 en el primer nivel de atención
Authors: Téllez-Perea Luis G. , Flores-Sánchez Luis A. , Madrigal-Morán Rosa
Published: November 2024

Objetivo: identificar la prevalencia de depresión en pacientes con diagnóstico de covid-19 en el primer nivel de atención. Métodos: estudio transversal analítico, con una población de 100 participantes. Se trabajó en consulta externa de la Unidad de Medicina Familiar No. 162, Ciudad de México, durante el periodo de abril a agosto de 2023. Se realizó muestreo no probabilístico. Se aplicó una cédula diseñada por los investigadores para registrar información del paciente. Además, se aplicó el Inventario de Depresión de Beck-II (bdi-ii) validado en México con un alfa de Cronbach 0.91. Se realizó el análisis estadístico y pruebas de χ2 y análisis de varianza anova, se realizó utilizando el software spss versión 25. Resultados: del total de la población de 28 pacientes fueron hombres (28%) y 72 mujeres (72%). De estos, 83 (83%) no presentaron depresión y 17 (17%) presentaron algún grado de depresión. La edad media fue de 32.1 años (rango: 20-40 años). Calculando el índice de masa corporal (imc), 50% presentó sobrepeso, 30% obesidad y 20% tuvo un índice de masa corporal normal. Conclusión: se encontró una prevalencia de 17% de depresión en pacientes con covid-19. A partir de este hallazgo, se sugiere que el médico familiar incluya el cuestionario bdi-ii en su práctica clínica, ya que puede ser una herramienta útil para el diagnóstico precoz y el tratamiento oportuno de la depresión en este grupo de pacientes.
Factores de riesgo para desarrollo de ansiedad, depresión y estrés en pacientes con COVID-19
Authors: Aguilar-Bonilla Rubén , Bustos-Melo María de Lourdes
Published: November 2024

Objetivo: determinar los factores de riesgo sociodemográficos para el desarrollo de ansiedad, depresión y estrés posterior a contagio por covid-19 en el equipo de salud básico de una unidad de medicina familiar durante la pandemia. Métodos: estudio transversal descriptivo realizado en la Unidad de Medicina Familiar (umf) No. 21 del Instituto Mexicano del Seguro Social, Ciudad de México, México; se incluyeron 154 personas que pertenecían al equipo de salud básico en la umf referida, se realizó un muestreo no probabilístico por conveniencia entre los meses de enero y abril de 2023. Se aplicó un cuestionario para obtener información sociodemográfica y la escala dass-21 para identificar rasgos de ansiedad, depresión y estrés. Con los datos obtenidos se realizó estadística descriptiva. Resultados: 112 pacientes presentaron rasgos sugerentes de estos trastornos. La ansiedad predominó en el personal de salud básico con una prevalencia de 56.5%, mientras que la depresión alcanzó 38.3% y el estrés 7.8%. En cuanto a los niveles específicos, se identificó un grado leve de estrés en 5.2%, ansiedad moderada en 26.6% y depresión leve en 29.2%, siendo estos los niveles más frecuentes para cada patología. Conclusión: se identificó el puesto de trabajo de enfermería, turno laboral vespertino, estado civil casados y género femenino, como las condiciones más presentes para desarrollar rasgos de ansiedad, depresión y estrés.
Acompañamiento pedagógico: estrategia que incide en el rendimiento académico de alumnos del nivel primario
Authors: Reynoso Dionicia , Martínez Solanlly , Magdalena Fernández María , Arzolay Wimer
Published: November 2024

El acompañamiento pedagógico es una estrategia de intervención que garantiza un alto porcentaje de éxito, no obstante, en ocasiones produce en los docentes rechazo, por el proceso de cómo se realiza, situación que incide en el rendimiento académico de los estudiantes. Para verificar lo planteado la investigacion tiene como propósito analizar el acompañamiento pedagógico como estrategia que incide en el rendimiento académico de alumnos del nivel primario, determinar cómo se realiza el proceso del acompañamiento, identificar las técnicas e instrumentos que se utilizan y evaluar la incidencia del acompañamiento pedagógico en el rendimiento académico de los estudiantes. El estudio aborda un enfoque cuantitativo, con aplicación de cuestionario a 117 docentes, 34 miembros del equipo de gestión de siete centros educativos y un análisis estadístico a 48 actas de calificaciones finales del segundo ciclo del nivel primario. Los resultados muestran que el acompañamiento pedagógico se realiza de forma planificada, con observaciones a la práctica áulica, realizan diálogos reflexivos y dan seguimiento. Estas acciones inciden de manera positiva en el rendimiento académico de los estudiantes, la mayoría obtuvo calificaciones A, B, C que les permitieron promover, hecho que permite inferir que, si se realiza un acompañamiento con estrategias y profesionalismo se obtienen