bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Spesolimab on Achieving Sustained Disease Remission in Patients with Generalized Pustular Psoriasis: Results from the Effisayil 2 Study
Authors: Gordon Kenneth , Lebwohl Mark , Barker Jonathan , Tsai Tsen-Fang , Merola Joseph , Conrad Curdin , Zhang Min , Hu Na , Hofmann Patrick , Thoma Christian , Eyerich Kilian
Published: January 2024

Introduction: Generalized pustular psoriasis (GPP) is a chronic, rare disease characterized by flares of widespread skin pustulation. Intravenous (IV) spesolimab, an anti-interleukin-36 receptor monoclonal antibody, is approved for GPP flare treatment; however, the optimal dosing and long-term efficacy of subcutaneous (SC) spesolimab treatment in patients with GPP has not yet been reported. We report the effect of SC spesolimab on achieving sustained disease remission in Effisayil 2 (NCT04399837), a 48-week trial that evaluated the efficacy and safety of SC spesolimab in preventing GPP flares.

 Methods: Patients with a history of GPP were randomized (1:1:1:1) to receive placebo (n=31), low- (n=31, 300 mg loading dose [LD]; 150 mg every 12 weeks [q12w]), medium- (n=31, 600 mg LD; 300 mg q12w) or high-dose (n=30, 600 mg LD; 300 mg every 4 weeks [q4w]) SC spesolimab over 48 weeks. Sustained remission was defined as GPP Physician Global Assessment (GPPGA) total score of 0 or 1 at all visits up to Week 48, or GPPGA total score of 0 or 1 and all GPPGA subscores ≤2 at all visits up to Week 48. Sustained pustular clearance was defined as GPPGA pustulation subscore of 0 at all visits from Week 4 to Week 48. Any use of IV spesolimab or another standard of care for GPP worsening was considered a failure of remission. Missing data were imputed by a sequential logistic regression multiple imputation method. Adjusted risk differences (RD) were calculated by the Mantel−Haenszel type-weighted average of differences.

 Results: 31 patients received placebo, and 30 patients received high-dose spesolimab. Compared to placebo, more patients had sustained remission in the high-dose arm using both GPPGA total score 0 or 1 (63.3% vs 29.0%; RD [95% CI] 0.35 [0.10–0.59]), and GPPGA total score 0 or 1 and all GPPGA subscores ≤2 (60.4% vs 29.0%; RD [95% CI] 0.32 [0.07–0.56]). Compared to placebo, more patients in the high-dose arm had sustained pustular clearance over 48 weeks (63.6% vs 25.8%; RD [95% CI] 0.38 [0.14–0.62]).

Conclusion: Overall, high-dose SC spesolimab q4w is effective for the long-term management of GPP skin symptoms.
Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in the Phase 3 Clinical Trials in Psoriasis, POETYK PSO-1 and PSO-2: Time to Meaningful Improvements in Itch as Assessed by the Psoriasis Symptoms and Signs Diary
Authors: Alexis Andrew F. , Merola Joseph F. , Zhong Yichen , Zhuo Joe , Becker Brandon , Napoli Andrew , Ross Jessie , Beaumont Jennifer , DeRosa Michael , Banerjee Subhashis , Armstrong April W.
Published: January 2024

Introduction: In the phase 3 POETYK PSO-1 and PSO-2 trials in psoriasis, patients completed the Psoriasis Symptoms and Signs Diary (PSSD) daily, recording the average severity of psoriasis symptoms and signs, including itch, over the past 24 hours. Patients receiving deucravacitinib experienced greater improvement in PSSD scores than patients receiving placebo or apremilast, as previously reported. In this analysis, we evaluate the time to improvement in itch in patients treated with deucravacitinib vs placebo in both POETYK trials.
Methods: In each trial, adults with moderate to severe plaque psoriasis were randomized 1:2:1 to placebo, deucravacitinib 6 mg once daily, and apremilast 30 mg twice daily; at Week 16, patients receiving placebo crossed over to receive deucravacitinib. Adjusted mean score change from baseline for the PSSD itch item was modeled for deucravacitinib vs placebo using an analysis of covariance model with factors for geographic region, body weight, and prior biologic use, and the baseline value as a covariate. Improvements of ≥2 points on individual PSSD items have been established earlier as meaningful to patients. Time to ≥2-, ≥3-, and ≥4-point improvements from baseline to Week 16 on the PSSD itch item was estimated with Kaplan-Meier methods. Cox models estimated hazard ratios (HRs) for these improvements. Missing data for each analysis were imputed using modified baseline observation carried forward methods.
Results: In each trial, significantly greater improvement from baseline in itch score was observed within 2 weeks with deucravacitinib vs placebo. Across both trials, the median (95% confidence interval [CI]) time to ≥2-point and ≥3-point improvements was 6.0 (5.0– 7.0) and 9.0 (8.0–11.0) weeks, respectively, for patients receiving deucravacitinib and not reached for patients receiving placebo (censored at Week 16). Patients receiving deucravacitinib were 3 times more likely to achieve a ≥2-point meaningful improvement in itch score than patients receiving placebo (HR [95% CI]: 3.0 [2.1–4.1] and 3.4 [2.6–4.5] in POETYK PSO-1 and PSO-2, respectively). HRs in favor of deucravacitinib increased as the threshold for improvement increased: at ≥3 points, HRs (95% CI) were 4.0 (2.6–6.1) and 4.9 (3.4–6.9), and at ≥4 points, HRs (95% CI) were 6.5 (3.4–12.4) and 8.8 (5.1–15.2), in POETYK PSO-1 and PSO-2, respectively.
Conclusion: Patients receiving deucravacitinib vs placebo experienced improvement in their itch within 2 weeks of treatment. About half of patients receiving deucravacitinib experienced meaningful improvement in itch within 6 weeks.
Sponsored by: Bristol Myers Squibb.
Perspective: Efficacy and outcomes for different lumbar interspinous devices (ISD) vs. open surgery to treat lumbar spinal stenosis (LSS)
Authors: Epstein Nancy E. , Agulnick Marc A.
Published: January 2024

Background:

Interspinous devices (ISD) constitute a minimally invasive (MI) alternative to open surgery (i.e., laminectomy/decompression with/without fusion (i.e., posterior lumbar interbody fusion (PLIF)/posterolateral instrumented fusion (PLF)) for treating lumbar spinal stenosis (LSS). Biomechanically, static and/or dynamic ISD “offload” pressure on the disc space, increase intervertebral foraminal/disc space heights, reverse/preserve lordosis, limit range of motion (ROM)/stabilize the surgical level, and reduce adjacent segment disease (ASD). Other benefits reported in the literature included; reduced operative time (OR Time), length of hospital stay (LOS), estimated blood loss (EBL), and improved outcomes (i.e., ODI (Oswestry Disability Index), VAS (Visual Analog Scale), and/or SF-36 (Short-Form 36)).

Methods:

Various studies documented the relative efficacy and outcomes of original (i.e., Wallis), current (i.e., X-STOP, Wallis, DIAM, Aperius PercLID), and new generation (i.e., Coflex, Superion Helifix, In-Space) ISD used to treat LSS vs. open surgery.

Results:

Although ISD overall resulted in comparable or improved outcomes vs. open surgery, the newer generation ISD provided the greatest reductions in critical cost-saving parameters (i.e., OR time, LOS, and lower reoperation rates of 3.7% for Coflex vs. 11.1% for original/current ISD) vs. original/current ISD and open surgery. Further, the 5-year postoperative study showed the average cost of new generation Coflex ISD/decompressions was $15,182, or $11,681 lower than the average $26,863 amount for PLF.

Conclusion:

Patients undergoing new generation ISD for LSS exhibited comparable or better outcomes, but greater reductions in OR times, EBL, LOS, ROM, and ASD vs. those receiving original/current ISD or undergoing open surgery.
Low-grade fibromyxoid tumor of the dura: A new entity?
Authors: Johnson Mahlon , Silberstein Howard , Korones David , Hussain Ali , Hawes Debra
Published: January 2024

Background:

Low-grade fibromyxoid tumors are uncommon in children. Their differentiation from high-grade fibromyxoid tumors, as seen in adults, is imperative to diagnosis. Awareness of the entity and its subsequent behavior may guide management and predict outcomes.

Case Description:

We describe the case of a previously unreported low-grade fibromyxoid tumor of the cerebellum in an 8-year-old male. Extensive immunohistochemical, next-generation sequencing, and attempted DNA methylation profiling are reported. There has been no recurrence during the 6-year follow-up. Screening excluded multiple myxoid tumors, including low-grade fibromyxoid sarcoma. The findings suggest that, with gross total resection, the lesions may not recur.

Conclusion:

The case of fibromyxoid tumor with 6-year follow-up and the limited literature of similar tumors are reviewed.
Мигранты, туристы, релоканты или оккупанты? Эссе о россиянах в Тбилиси, поломанном гостеприимстве и праве на город
Authors: Чернышева Любовь
Published: January 2024

В эссе я предлагаю читателям проследить за ходом моей собственной работы с концепцией права на город для анализа того, как обживаются в Тбилиси россияне, переехавшие за последние 10 лет, в том числе после начала военных действий на территории Украины в феврале 2022 года. Материалы, собранные в ходе полевой работы в августе 2022 года, позволяют мне поставить под вопрос универсализм, свойственный литературе о праве на город, и в перспективе пересечения множества факторов – от экономического статуса до принадлежности к бывшей метрополии – рассмотреть возможность осуществления права на город россиянами, оказавшимися в Тбилиси. Я рассматриваю россиян, с одной стороны, как «туристов» и «цифровых номадов», ориентированных на потребление городских благ, с другой стороны – как «мигрантов», которые настроены на участие в городской жизни, но в некоторых случаях исключаются из нее местным сообществом. К этому аналитическому разделению я «примеряю» концепцию права на город и показываю, в каких местах она (не) работает. Я прихожу к выводу, что концепция, во-первых, не учитывает пересечения различных характеристик, служащих основанием для возникновения неравенств, которые могут появляться внутри группы потенциальных субъектов права на город. Я предлагаю внимательнее относиться к различиям внутри группы «россияне в Тбилиси» и рассматривать переключения между конкретными ситуациями проявления права на город. Я также обращаю внимание на то, что концепция имеет этическое измерение, связанное с проявлением сострадания к субъектам права на город, что делает проблематичной работу с ней в таких сложных контекстах, как миграция россиян в Грузию в 2022 году.
Текст на русском языке
PENGENALAN ANGKA 1-20 DALAM PENGEMBANGAN KOGNITIF SISWA TK KARTIKA 1-21 PEKANBARU
Authors: Nurhaliza Nurhaliza , Winarsih Inggit , Wahyuni Ida Windi
Published: January 2024

The development of cognitive abilities is the ability to think of children to develop creativity towards the world around them. This type of research is classroom action research conducted in two cycles. This study aims to evaluate the increase in the ability to recognize the symbol number 1-20 through child worksheets at the age of 5-6 Years at TK Kartika 1-21 Pekanbaru. Research subjects are teachers and children aged 5-6 years with a total of 15 children. Based on the results of the study in spelling out by pointing objects 1-10 there were 10 children (67%) with the criteria of Developing by Expectations (BSH), then in appointing a symbol of 1-20 there were 9 children (60%) with the criteria of Developing Accordance with Expectations (BSH), and in connecting or pairing 1-10 symbols there are 10 children (67%) with the criteria of Developing by Expectations (BSH) and this shows that the ability to recognize numbers 1-20 in TK Kartika 1-21 Pekanbaru has met the criteria well.
Pilihan Rasional Orang Tua Menitipkan Anak Di Baby Daycare
Authors: Reski Putri , Marnelly T. Romi , Risdayati Risdayati , Resdati Resdati
Published: January 2024

Sociologically, the family has important role in the parenting process. This role is carried out by parents, especially mothers. Currently, there is a part of mothers not only work in the domestic sector but also in the public sector. This means that this parenting role needs to be taken by other socialization agents so that parents can still work.  So this study aims to determine the rational choice of parents to leave their children in the TPA and to find out the process of parents choosing Siti Walidah Baby Daycare as a substitute daycare place. This study uses descriptive qualitative research methods. The study included daycare manager and 5 informants from the parents. In determining the subjects in this study, the authors used a purposive sampling technique with the criteria of parents or guardians choosing the full daycare program, entrusting more than one child, and having children aged 0 to 5 years. According to the study's findings, all research subjects, as parents, have the same motivation for leaving their children in daycare; whereas they previously began with their situation and their partners, who work 8 hours a day in office operations and no one takes care of children at home, they are now looking for other alternatives to fill the role. child care, compare one day care center with another, and also consider all aspects to decide the choice they take. In the end, they decide to go with Siti Walidah Babysitting.
Keterampilan Sosial dan Emosional Anak Usia Dini; Analisis Gender
Authors: Sitorus Ahmad Syukri
Published: January 2024

Gender differences have an impact on the behavior displayed. Understanding these differences will provide a real understanding of differences in children's behavior based on gender, including children's social and emotional behavior. The research aims to see how children's social and emotional skills are based on the child's gender. The method used is a comparative study that looks at differences in social skills and emotional skills of early childhood based on gender. Data collection used instruments to measure children's social and emotional skills to 45 boys and 32 girls in seven early childhood education units in North Sumatra. Data were analyzed through t-test. The results showed that the average social skills of boys were 28.36 and 29.88 for girls' social skills, and the average emotional skills of boys were 22.18 and 23.56 for girls' emotional skills. This means that descriptively the emotional skills of girls are higher than the emotional skills of boys. The results of the study are clear that girls have higher social skills and emotional skills than boys. This is because girls have emotional expressions that are more neutral, calm and peaceful.
Analisis Karakter Jujur pada Film Animasi Hafiz dan Hafizah
Authors: Dianti Yunia Sari  , Ulpah Fauziah
Published: January 2024

Honest character is one of the characters that needs to be introduced to children from an early age. Honest character can accustom children to act as they are and not lie. To instill the character value of honesty in early childhood can be through a good example or model. The model itself can be a film or an individual who can provide a positive example for children. The animated film Hafiz and Hafizah is one of the films that presents positive content about good behavior for early. Such honest behavior. So indirectly children can get to know honest characters through an animated film. The purpose of this research is to describe and find out the results of honest character analysis in the animated film Hafiz and Hafizah. This study uses a qualitative approach, with qualitative descriptive research methods through content analysis techniques for the animated films Hafiz and Hafizah by observing and recording through showing episodes from 2020 to 2022. There are five episodes from the animated films Hafiz and Hafizah, namely 1) trusting a wallet, 2) greed becomes a problem, 3) Hafiz's smart pen is missing, 4) the bazzar for goodness, and 5) an Islamic children's song, let's tell the truth. The results of research on honest character analysis in the animated film Hafiz and Hafizah contain honest characters that are suitable for early childhood such as be and tell the truth, admit mistakes and apologize for mistakes that have been made.
Menurunkan Perilaku Agresif Siswa Taman Kanak-kanak Melalui Aktivitas Bermain Peran Prososial
Authors: Desvianti Erika
Published: January 2024

One of the problems that parents and teachers often complain about is aggressive behavior in kindergarten students because this aggressive behavior is a problem that often occurs in children and is always there in every school year. Several studies have shown that since childhood the handling and prevention of aggressive behavior must be done. This is done in order to prevent disruptive behavior that may arise in the future and have long-term effects so that it can cause negative effects on children and continue until they are adults. One effort that can be done to reduce aggressive behavior is to develop prosocial behavior. Aggressive individuals are taught to behave in non-aggressive ways. This approach is felt to be more effective in reducing aggression by using the principle of behavior modification learning that focuses on strengthening non-aggressive behavior. Prosocial behavior developed using role playing methods with prosocial themes. The development of this prosocial behavior involved 12 kindergarten students in Yogyakarta. Prosocial behavior is taught using several indicators of prosocial behavior such as helping, sharing, entertaining and collaborating. The Time-series Group Nonequivalent No-Treatment Control Group quasi-experimental design is the design used in this study. Based on the results of this research data analysis it is proven that the aggressive behavior of students in Kinder garten can be reduced through prosocial role playing significantly in the experimental group when compared to the aggressive behavior group in the control group (z=-2.169; p<0.05).
Stimulasi Perkembangan Aspek Seni Anak Usia Dini
Authors: Henny Henny , Saleh Rachman , Marwah Marwah , Kurniati Asma , Suhardin Neka
Published: January 2024

This study aims to determine the process of stimulating early childhood artistic development in Banca Patola Kindergarten, Baubau City. This research is a qualitative descriptive study. Data is collected by observing, interviewing, and documenting. Data were analyzed by reducing, displaying and verifying. The results showed that the process of stimulating children's artistic development was carried out with activities such as: (1) humming or singing while doing something; (2) be creative with beads, origami paper and natural materials; (3) sanitary activities such as mixing colors, finger painting; (4) drawing in various ways and forms; (5) coloring activities. In addition, several stimulations that can be applied to increase the achievement of artistic development aspects in Banca Patola Kindergarten, namely: (1) the teacher's role is to provide support and facilities for children to listen to the songs they like; (2) the teacher always gives appreciation in the form of praise; (3) the teacher facilitates activities that stimulate children's art; (4) the teacher gives rewards to children for their achievements in activities.
HUBUNGAN ANTARA KEGIATAN BERMAIN MAKE A MATCH DENGAN KEMAMPUAN BERHITUNG ANAK USIA DINI
Authors: Ai Ai Siti Komariah , Yulianingsih Yuyun , Kurnia Aam
Published: January 2024

The purpose of this study was to determine the reality of making match play activities, the reality of early childhood numeracy skills, and the relationship between make a match play activities and early childhood numeracy skills in Group B2 RA Mukhlishiina Lahuddiin Cinunuk Village, Cileunyi District, Bandung Regency. The research method used in this study uses a quantitative correlational method. The results of the analysis on the activity of playing make a match obtained an average value of 80.95. This value is in the 80-100 interval with a very good category. Meanwhile, early childhood numeracy skills obtained an average value of 78.6. This value is in the 70-79 interval with a good category. The relationship between the activities of playing make a match with early childhood numeracy skills obtained a correlation coefficient of 0.937. The value of this correlation coefficient is included in the very strong category because it is in the 0.800-1,000 interval. The results of the significance test obtained tcount = 10.04 > ttable value = 2.14. This means that the null hypothesis is rejected and the alternative hypothesis is accepted. Thus, the activity of playing make a match has a significant relationship with early childhood numeracy skills in Group B2 RA Mukhlishiina Lahuddiin Cinunuk Village, Cileunyi District, Bandung Regency. Meanwhile, the contribution or influence on the activity of playing make a match on early childhood numeracy skills is 87.8%. Thus 12.2% is influenced by other factors.
PENGARUH KEGIATAN BERMAIN KREASI MOZAIK DENGAN WALLPAPER TERHADAP KEMAMPUAN MOTORIK HALUS ANAK USIA 5-6 TAHUN DI TAMAN KANAK-KANAK E-SCHOOL
Authors: Mahmuddin Mardiana , Parwoto  , Ilyas Sitti Nurhidayah
Published: January 2024

This study aims to determine the effect of playing mosaic creations using wallpaper material on fine motor skills in children aged 5-6 years in e-school Kindergarten by using quantitative research methods. The subjects of this study were children aged 5-6 years e-school Kindergarten, totaling 12 children. This study wanted to determine whether or not there is an influence between two variables, namely the activity of playing mosaic creations and children's fine motor skills. Based on the results of the hypotheses study, the value of Tcount 30 ≥ Ttable 2.228 and the value of Zcount 3.25 ≥ Ztable 0.4994. This means that there is a variable effect of playing mosaic creations on fine motor skills in children aged 5-6 years in e-school Kindergarten
PERKEMBANGAN BAHASA ANAK USIA 4-5 TAHUN DITINJAU DARI ASPEK FONETIK DAN ASPEK SEMANTIK
Authors: Anisawwn Anisa Wiwin Handayani , Chandra Anita , Sulianto Joko
Published: January 2024

Language Development Children aged 4-5 years are basically able to pronounce conversations correctly and are able to say what they want. However, in the daily life of children aged 4-5 years, there are those who have delays in language development or are less clear in the pronunciation of letters. The purpose of this study is that researchers want to examine the language development of children who experience delays with the method of phonetic and semantic stages. The method used by the researcher is classroom action with a variety of role-playing and sound playing. The results of the study indicate that the language of RR has significant increase, namely, RR is willing to communicate with his peers and pronounces the letter S clearly.
PENGEMBANGAN ALAT PERMAINAN EDUKATIF (APE) ULAR TANGGA UNTUK MENINGKATKAN KEMAMPUAN MOTORIK KASAR ANAK USIA 4-5 TAHUN
Authors: Rismadani Fitri , Satria Defni , Kurnia Rita
Published: January 2024

This study aims to determine the development and feasibility of the snake ladder educational game tool (APE) to improve the gross motor skills of children aged 4-5 years. The research method used is Research and Development (RND), which produces a product and can test the effectiveness of the product. The data analysis technique used by the researcher in this study is a quantitative descriptive analysis technique. Data analysis for product feasibility uses the assessment of the results obtained from learning media experts and material experts in the form of a questionnaire instrument (questionnaire). The resulting product development in the form of an educational game tool (APE) snake ladder made of banner printing material with a size of 2.4 x 3 meters is used as a learning medium to improve gross motor skills of children aged 4-5 years. The validation results obtained in the development of the snake and ladder educational game tool (APE) are very satisfying. The results of material validation are in the "very feasible" category. While the results of media validation are having a "very feasible" validation category. The results of the two validation categories show "very feasible", therefore the development of the snake and ladder educational game tool (APE) is certainly very suitable to be used to improve the gross motor skills of children aged 4-5 years.
PERAN GURU DALAM PEMBELAJARAN DARING BAGI ANAK USIA DINI ERA PANDEM COV ID-191
Authors: Shofiyati  , Sumiyati Sumiyati , Candra Eka Novita
Published: January 2024

During the COVID-19 pandemic, various activities were limited to education carried out by distance education (online). This research is qualitative research and in data analysis, this research will use a qualitative verification model which is carried out in three steps, namely data reduction, data presentation, and drawing conclusions. The objects in this research are educators, parents, and students at RA Al Jauhariyyah Kajen. The results of this study are the role of educators in the implementation of distance/online learning, not only to prepare materials for students but also to become communicators who play an active role in guarding parents, in accompanying children during the online learning process. Online learning plans have been designed in such a way and involve parents in determining competencies/indicators during online learning, designing children's activities, materials, and children's learning resources prepared by the institution to make it easier for parents to accompany children during online learning. It is hoped that the teacher's role and involving parents in children's learning will create synergy, responsibility, and positive relationships between parents and teachers to jointly increase children's growth and development.
KREATIVITAS KEPEMIMPINAN KEPALA SEKOLAH DALAM MENGAPLIKASIKAN KEMAMPUAN MEMBACA AL-QUR’AN ANAK USIA DINI PADA MASA NEWNORMAL
Authors: Mesran Mesran , Harahap Hotni Sari , Tursina Ade
Published: January 2024

This research is a field research with a qualitative descriptive method, the subject and informants are the principal and teachers and children of group B at RA Hidayatus Shibyaan, which is located on Jln. Veterans Market 6 Manunggal Kab. Deli Serdang. Data collection methods used is observation, interviews and documentation. The results showed that the implementation of the creativity of the principal of RA Hidayatus Shibyaan in applying the ability to read the Al-Qur’an for children, namely through the guidance of RA teachers holding meetings, teacher professional training, direct monitoring of the learning process, and the implementation of al-Al-Qur’an learning with the Iqro method through daily routine. The inhibiting factors in the implementation of creativity are work, less enthusiastic responses from stakeholders, and internal and external motivation. While the supporting factors are good cooperation between stakeholders, positive emotion teachers, the completeness of the Koran learning media, a comfortable and harmonious work environment, and the implementation of an effective
PENDIDIKAN SEKS BAGI ANAK USIA DINI MENURUT HADIST NABI
Authors: Bakhtiar Nurhasanah , Nurhayati
Published: January 2024

Early age (0-6 years) is the golden age. This period is the formation period that determines adolescence and adulthood. Islam as a perfect religion has governed all lines, one of which is about educating young children, especially related to sex education. This study aims to explore how sex education for early childhood in the explanation of the Prophet's hadith. This type of research used by researchers is library research (library research) by tracing various hadith books and the work of scholars and experts related to early childhood sex education. As a qualitative study, the data analysis is used in three stages (data reduction, data display, and concluding). The results of this study state that sex education for young children does not explain sex itself to children, but means: first, explain and introduce their identity as men or women through differences in genitalia. Second, it teaches children moral values ​​and character and politeness of decency. Third, provide a warning for parents to educate their children at an early age following the religious directions contained in the Koran and Hadith.
STIMULASI METODE TIME OUT DALAM MENERAPKAN SIKAP DISIPLIN ANAK USIA DINI
Authors: Lestari Mega Cahya Dwi
Published: January 2024

The time out method is effective in stimulating discipline in early childhood. The success factor of the time-out method can be found in the age difference that causes different stages of development in each child which includes cognitive development, moral development, discipline, and the consistent role of parents and teachers in the implementation of the correct time-out procedure, especially the provision of rewards following aim. Disciplinary education needs to be instilled in children from an early age that if children make mistakes they will certainly receive consequences, for this reason, the punishment function in children's education. Discipline is a behavioral value that can be done by force and can be done voluntarily. In early childhood, this form of discipline must be implemented voluntarily and through play. Teachers, the community, and parents are the most influential factors in disciplining children.
PENDIDIKAN KARAKTER BERBASIS KEARIFAN LOKAL MELALUI PERMAINAN TRADISIONAL TARIK UPIH DALAM MENINGKATKAN MOTORIK KASAR ANAK
Authors: Muazimah Ajriah , Wahyuni Ida Windi
Published: January 2024

Character education is the foundation of children for their future and character education serves as the basis for self-discipline and becomes a means of controlling children when they behave. Values ​​that are not necessarily by the surrounding community. Noble values ​​can be sourced from existing local wisdom, wisdom values ​​to realize the aspirations of the nation physically and mentally. Through traditional games, it is also a form of tradition in people's lives to create an atmosphere and expression that is fun and uplifting to build children's character from an early age. Traditional games that can be categorized as good must be able to help aspects of children's development both physically and psychologically. Traditional games of attraction are sufficient to explore the physical abilities of children. When playing the game of attraction, children interact a lot with others, control emotions, cooperate, respect friends, and hone language skills. Introducing local wisdom through traditional games of Tarik-upih to children from an early age will form a person who cares and has a love for their culture. So that there will be generations with personalities and functional values ​​for the nation and state.
PENGARUH KERJASAMA ORANGTUA DAN GURU TERHADAP PERKEMBANGAN SOSIAL EMOSIONAL ANAK KELAS B PAUD IT BUNAYYA
Authors: Kiya Aminoh , Alucyana Alucyana
Published: January 2024

This study aims to determine the effect of parent-teacher cooperation on the socio-emotional development of early childhood in class B PAUD IT Bunayya. By using quantitative research methods, the subjects of this research are the parents of class B PAUD IT Bunayya students, totaling 64 students. This study wanted to know whether or not there is an influence between two variables, namely the cooperation of parents and teachers and the social-emotional development of early childhood. The data analysis technique is the SPSS test. Based on the results of the study of hypotheses, the simple linear value of parent and teacher cooperation on children's social-emotional development is 16,793 with a sig. (2-tailed) value of 0.000. Compared to the significance level of 0.05(5%), this sig. (2-tailed) value is greater than 0.05(5%). This means that there is an influence of the parent-teacher cooperation variable on the emotional social development of early childhood in class B PAUD IT Bunayya. The researcher saw the magnitude of the coefficient of determination (R square) which was 0,213 which showed the magnitude of the influence of parent and teacher cooperation on children's social-emotional development.
HUBUNGAN AKTIVITAS MENGGAMBAR MENGGUNAKAN TEKNIK KERING DENGAN PERKEMBANGAN MOTORIK HALUS ANAK USIA DINI
Authors: Imani Nuri
Published: January 2024

This study aims to determine the reality of drawing activities using dry techniques, the reality of the fine motoric development of early childhood, and the reality of the relationship between drawing activities using dry techniques and the fine motoric development of children aged in group B RA Nurul Hikmah Kertasari Garut. Quantitative correlation is one of the methods used in this research. Children of group B RA Nurul Hikmah Kertasari Garut are the subjects of this study, totaling 15 children in the 2020/20201 period. Observation, performance, and documentation are data collection techniques in this study. The value of the calculation results on variable X obtained an average value of 70. This value is in a good category because it is in the interval 66-79. Meanwhile, the Y variable obtained an average value of 71. The value is included in the good category where it is in the interval 66-79. The relationship between drawing activities using dry techniques and fine motor development of early childhood children in group B RA Nurul Hikmah Kertasari Garut has a correlation coefficient of 0.47. This figure is in the interval 0.4000-1000 so it is included in the strong category. The result of the value from the significance is known as tcount> ttable (1.92 <1.93), the price of ttable = 1.93, it can be translated that is accepted, thus there is a significant relationship between the activity of drawing using dry techniques and the development of fine motor skills in early childhood.
Periodic table screening for enhanced positive contrast in MRI and in vivo uptake in glioblastoma
Authors: Herraiz Aitor , Morales M. Puerto , Martínez-Parra Lydia , Arias-Ramos Nuria , López-Larrubia Pilar , Gutierrez Lucía , Mejías Jesús , Díaz-Ufano Carlos , Ruiz-Cabello Jesús , Herranz Fernando
Published: January 2024

The quest for nanomaterial-based imaging probes that can provide positive contrast in MRI is fueled by the necessity of developing novel diagnostic applications with potential for clinical translation that current gold standard probes cannot provide. Although interest in nanomaterials for positive contrast has increased in recent years, their study is less developed than that of traditional negative contrast probes in MRI. In our search for new magnetic materials with enhanced features as positive contrast probes for MRI, we decided to explore the chemical space to comprehensively analyze the effects of different metals on the performance of iron oxide nanomaterials already able to provide positive contrast in MRI. To this end, we synthesized 30 different iron-oxide-based nanomaterials. Thorough characterization was performed, including multivariate analysis, to study the effect of different variables on their relaxometric properties. Based on these results, we identified the best combination of metals for in vivo imaging and tested them in different experiments. First, we tested its performance on magnetic resonance angiography using a concentration ten times lower than that clinically approved for Gd. Finally, we studied the capability of these nanomaterials to cross the affected blood-brain barrier in a glioblastoma model. The results showed that the selected nanomaterials provided excellent positive contrast at large magnetic field and were able to accumulate at the tumor site, highlighting the affected tissue.
Fast formation of anode-free Li-metal batteries by pulsed current
Authors: Cicvarić Katarina , Merker Leon , Zhang Bojing , Rahmanian Fuzhan , Gaberšček Miran , Stein Helge Sören
Published: January 2024

Anode-free Li-metal batteries offer high energy density but are prone to dendrite formation during charging which can cause catastrophic failures. Ensuring dendrite-free smooth Li deposits during charging is therefore necessary. Suppressing dendrite growth can be achieved by pulsed current charging, especially during the formation cycle that largely determines the corrosion trajectory of a cell. As opposed to the constant-current technique, pulsed current techniques apply intermittently stopped current flows. This work investigates the electroplating of metallic Li onto a Cu foil current collector under constant-current and pulsed current formation protocols. In addition to smoother, less resistive electroplated metallic Li deposits and increased Coulombic efficiency, we show that by employing an optimized pulsed current formation protocol, the formation process is accelerated by a factor of 2 compared to a C/20 protocol. Finally, by employing a simple regression coupled to experimentation, we propose the pseudo-IR-drop to be used for live adjustment of pulsed current protocols i.e., individually approach each cell at all SOC during formation.
Innovative Integration of Butina Clustering with Ensemble Learning Techniques for the Refined Pharmacophore Modeling of Apelin Receptor Agonists: A High-Impact Computational Approach
Authors: Tran Xuan-Truc Dinh , Phan Tieu-Long , To Van-Thinh , Tran Ngoc-Vi Nguyen , Nguyen Nhu-Ngoc Song , Nguyen Dong-Nghi Hoang , Tran Ngoc-Tam Nguyen , Truong Tuyen Ngoc
Published: January 2024

3D pharmacophore models describe the ligand’s chemical interactions in their bioactive conformation. They offer a simple but sophisticated approach to decipher the chemically encoded ligand information, making them a valuable tool in Drug Design. Our research summarized the key studies for applying 3D pharmacophore models in virtual screening for APJ receptor agonists. Recent advances in clustering algorithms and ensemble methods have enabled classical pharmacophore modeling to evolve into more flexible and knowledge-driven techniques. Butina clustering categorizes molecules based on their structural similarity (indicated by the Tanimoto coefficient) to create a structurally diverse training dataset. The ensemble learning method combines various individual pharmacophore models into a set of pharmacophore models for pharmacophore space optimization in virtual screening. This approach was evaluated on Apelin datasets and afforded good screening performance, as proven by receiver operating characteristic, enrichment factor, Güner-Henry score, and F-measure. Although one of the high-scoring models achieved statistically superior results in each dataset, the ensemble learning method including Voting and Stacking method balanced the shortcomings of each model and passed with close performance measures.
Oxidative Cyclization and Enzyme-free Deiodination of Thyroid Hormones
Authors: Spils Julian , Caspers Lucien , Puylaert Pim , Nachtsheim Boris Johannes
Published: January 2024

We introduce the first non-enzymatic deiodination of thyroid hormones from a so far unknown hypervalent iodaoxinium state. After developing oxidative processes for thyroxine(T4)-derived model cyclic diaryliodonium salts, we successfully produced an iodaoxinium salt through the direct oxidation of O-and N-protected T4. DFT calculations revealed a novel halogen bonding-based deiodination mechanism, circumventing the traditional selenium-dependent pathways. Our findings open new avenues in thyroid hormone chemistry, suggesting alternative mechanisms for their involvement in metabolic processes, regulation of oxidative stress, and gene expression.
High NO2 gas sensing performance of tin-dichalcogenides at room temperature via high-energy mechanical milling synthesis
Authors: Melquiades Miecio de Oliveira , Oliveira Leonardo Soares , Silva Ranilson Angelo , Orlandi Marcelo Ornaghi
Published: January 2024

Eco-friendly gas sensing devices with simple architecture, reduced cost, and high performance at room temperature are searched to replace the traditional metallic oxide materials due to environmental issues. Lamellae semiconducting materials have shown promising detection properties for this purpose. Here, we investigated the sensing response of SnS2, Sn(S0.5Se0.5)2, and SnSe2 tin-dichalcogenides prepared by high-energy mechanical milling. High R_(NO_2 )/R_air response signals, from 102 to 106, for 2-100 ppm of NO2 were observed for temperatures between 30 °C and 300 °C. The materials were not sensitive to CO, while H2 detection could only be observed above 200 °C, implying high NO2 selectivity. Additionally, we investigated the influence of samples dilution in water and isopropanol on grain size and morphology. We found that isopropanol crystallizes amorphous selenium phase dispersed in the Sn-Se system and increase the agglomeration in the Sn(S0.5Se0.5)2 system. Deformed and defective particles were observed regardless the preparation methodology. This unique morphology might increase surface reactivity for selective NO2 detection by physisorption, owing a high adsorption/desorption rate at room temperature.
Continuous Flow Scale-Up of Enantiospecific Solid-to-Solid Photodecarbonylation Chemistry Through Pulsed Flow Operation and Inline Crystallization
Authors: Vandekerckhove Bavo , Ruttens Bart , Metten Bert , Stevens Christian , Heugebaert Thomas
Published: January 2024

The enantioselective formation of C-C bonds is arguably one of the most important reactions in organic chemistry. While elegant solutions have been devised for the total synthesis of several natural products, active pharmaceutical ingredients (API), and related scaffolds, efficient methods that strive towards the principles of green chemistry remain highly desirable additions to the synthetic organic toolbox. Additionally, modern strategies become increasingly challenging when the desired structures are highly strained, sterically encumbered, or contain adjacent quaternary chiral centers. In this research, the hexasubstituted ketone d,l-2,4-dimethyl-3-oxo-2,4-diphenylpentanedinitrile was chosen as a highly strained and chiral proof-of-concept substrate to evaluate the scalability of solid state photoelimination chemistry. Performing the photodecarbonylation of easily accessible alpha-chiral ketones in the solid state physically restricts the mobility of the generated radical intermediates, resulting in high regio- and enantiospecificity. Additionally, aqueous suspensions can be used, resulting in a simple filtration as the only purification step. The continuous flow HANUTM 2X 15 photoreactor, preceded by a custom inline crystallization setup, were shown to be key enabling technologies to achieve the previously problematic continuous operation and scale-up of these reactions. A solid-to-solid photochemical process was successfully optimised, resulting in a STY of 3.9 kg h-1 m-3.
Iodine(III)-Catalyzed Oxidative Cyclization of Aryl Amines to Construct Benzimidazoles
Authors: White Carmen , Cazares Sherlyn , Gonzales-Cortes Efren , Driver Tom
Published: January 2024

An I(III)-catalyzed oxidative cyclization reaction using Selectfluor as the oxidant was developed that converts ortho-substituted anilines to benzimidazoles is reported. The mild reaction requires as little as 0.5 mol % of iodobenzene tolerating electron-poor groups on the aniline portion. The size of the ring can be varied to access the pyrrole, azepine, and azocines scaffolds. Preliminary mechanistic investigations suggest that benzimidazole formation occurs via cationic reactive intermediates, and an intramolecular kinetic isotope effect of 1.98±0.01 was measured.
A Review on Clinical Presentation and Treatment of Coronavirus (Covid 19)
Authors: S Divya , Bachu Naveena , Yadala Prapurnachandra
Published: January 2024

In 2021, 2022, and 2023, the following medications are used to treat and manage coronavirus: chloroquine, hydroxychloroquine, favipiravir; Remdesivir, tocilizumab, and anakinra. Analysis of the clinical presentations concerning COVID-19 was done between 2021 and 2023. When compared to other clinical presentations, fever, cough, chest pain, and dyspnea are the most frequently occurring clinical manifestations. Chloroquine and hydroxychloroquine are the medications most frequently used in the treatment management of COVID-19 to prevent the coronavirus between 2021 and 2023. It is commonly repeated clinical manifestations (Fever, Cough, Chest pain, dyspnea) when compared to other clinical presentations. In the treatment management of COVID-19, the drugs are (chloroquine, and hydroxychloroquine) most commonly used to prevent coronavirus from 2021 to 2023.
Using Worker Flows to Assess the Stability of the Early Childcare and Education Workforce, 2010-2022
Authors: Fee Kyle D.
Published: January 2024

Turnover is a particular problem among childcare workers and less so among preschool and kindergarten teachers. In 2022, turnover in childcare work was about 65 percent higher than in a typical job, while attrition among preschool and kindergarten teachers was on par with the typical occupation.
IMPLEMENTATION OF THE SOCIODRAMA METHOD AS AN EFFORT IMPROVING HISTORY LEARNING OUTCOMES IN PROCLAMATION OF INDEPENDENCE MATERIALS
Authors: Sukriyatun Gunarti
Published: January 2024

Abstract. The use of the Sociodrama learning method is a proposed solution to improve student learning outcomes in Social Sciences. To prove that this model can improve students' understanding, Classroom Action Research is carried out by carrying out the learning process with the Sociodrama method, which is carried out on students in class 9B SMPN 16 Bogor. The purpose of this study is to increase student motivation in learning, create a comfortable and happy atmosphere in the learning process, improve student learning outcomes and teacher skills in using various learning methods. This research was carried out in 2 cycles with activities consisting of (1) Planning, namely making learning tools (RPP), observation sheets, test questions, (2) Action (classroom teaching and learning), (3) Observation (assessment by collaborators during KBM) and (4) Reflection (discussing weaknesses and strengths during KBM between teaching teachers and collaborators). The data were obtained from the results of pre-test and post-test and assessment of collaborators/observers. The second cycle is carried out by re-practicing sociodrama which has been equipped with sociodrama scripts. Based on the data obtained from the results of this study, it proves that the use of the sociodrama method can improve student learning outcomes. It is proven by the class average value which at the beginning of 45.81 increased to 74.46. Because of this.
Keywords: Sociodrama Method, History Learning Outcomes
THE EFFECT OF LEARNING STYLE ON STUDENT ACADEMIC ACHIEVEMENT IN SEMARANG
Authors: Yogatama Adiprana
Published: January 2024

Abstract. This article aims to identify student learning styles, various learning styles, and academic achievement. The approach used in this research is a quantitative approach with a survey method. The variables in this study are multiple variables, namely the identification of student learning styles on student academic achievement in Semarang. The sample of this research is 319 active students at the University of Semarang. The most widely used learning style by students in Semarang is the visual and auditory learning style. Student learning achievement in Semarang is not influenced by learning styles consisting of visual, auditory, reading/writing and kinesthetic.
Keywords: learning styles, academic achievements, students