bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Plant Physiology for Model Plants under Abiotic Stress Conditions
Authors: Sokouti Babak
Published: April 2024

Extreme temperatures, drought, and high soil salinity are some of the significant abiotic stresses that can severely impact crop yields, posing a threat to global food production. Comprehensive studies on model plant species are crucial for understanding their biochemical, physiological, and molecular responses to abiotic stresses. Identifying stress response mechanisms and potential targets can aid in developing stress-tolerant crop varieties. Additionally, elucidating the functions of reactive oxygen species is essential for this research area. In model plants, the perception of abiotic stresses is a complex phenomenon that entails intricate interactions between hormones, gene regulation, and physiology. The presence of specific stress receptors and sensors contributes to this perception. Activating signaling pathways involves a cascade of events, starting with generating reactive oxygen species, then calcium signaling and MAP kinase signaling. Because of these processes, transcription factors and genes susceptible to stress are ultimately activated in the latter stages. It starts with a series of physiological and biochemical modifications, which entail adjustments in photosynthesis and the accumulation of osmoprotectants. We have gained significant insights from studying model plant stress responses, but there remain considerable challenges in effectively applying these findings to enhance crop resilience. These challenges contribute to reproducing the results across various species. These difficulties arise because of phenotypes, molecular mechanisms, and genetic differences. The utilization of model plants will persist in their crucial role as essential systems for unraveling the complexities of plant stress responses. They will play a vital role in overcoming present constraints, particularly in areas such as the mathematical modeling of plant physiology. The exploration of gene function across species can significantly contribute to efforts aimed at improving crops. The key to addressing threats to global food security and promoting crop stress resilience lies in adopting a multi-pronged approach that uses model plant systems.
Addressing Data Absenteeism and Technology Chauvinism in the Use of Gamified Wearable Gloves Among Older Adults: Moderated Usability Study
Authors: Lee Edmund W J , Tan Warrick W , Pham Ben Tan Phat , Kawaja Ariffin , Theng Yin-Leng
Published: April 2024

Background

Digital health technologies have the potential to improve health outcomes for older adults, especially for those recovering from stroke. However, there are challenges to developing these technologies, such as data absenteeism (where older adults’ views are often underrepresented in research and development) and technology chauvinism (the belief that sophisticated technology alone is the panacea to addressing health problems), which hinder their effectiveness.

Objective

In this study, we aimed to address these challenges by developing a wearable glove integrated with culturally relevant exergames to motivate older adults to exercise and, for those recovering from stroke, to adhere to rehabilitation.

Methods

We conducted a moderated usability study with 19 older adults, of which 11 (58%) had a history of stroke. Our participants engaged in a 30-minute gameplay session with the wearable glove integrated with exergames, followed by a quantitative survey and an in-depth interview. We used descriptive analysis to compare responses to the System Usability Scale between those who had a history of stroke and those who did not. In addition, we analyzed the qualitative interviews using a bottom-up thematic analysis to identify key themes related to the motivations and barriers regarding the use of wearable gloves for rehabilitation and exercise.

Results

Our study generated several key insights. First, making the exergames exciting and challenging could improve exercise and rehabilitation motivation, but it could also have a boomerang effect, where participants may become demotivated if the games were very challenging. Second, the comfort and ease of use of the wearable gloves were important for older adults, regardless of their stroke history. Third, for older adults with a history of stroke, the functionality and purpose of the wearable glove were important in helping them with specific exercise movements.

Conclusions

Our findings highlight the importance of providing contextual support for the effective use of digital technologies, particularly for older adults recovering from stroke. In addition to technology and usability factors, other contextual factors such as gamification and social support (from occupational therapists or caregivers) should be considered to provide a comprehensive approach to addressing health problems. To overcome data absenteeism and technology chauvinism, it is important to develop digital health technologies that are tailored to the needs of underserved communities. Our study provides valuable insights for the development of digital health technologies that can motivate older adults recovering from stroke to exercise and adhere to rehabilitation.
Real-World Registry on the Pharmacotherapy of Multiple Myeloma and Associated Renal and Pulmonary Impairments in the Greater Gulf Region: Protocol for a Retrospective Real-World Data Study
Authors: Nourallah Abdulnaser , Alshehri Abdulrahman , Alhejazi Ayman , Usman Binyam , ElGohary Ghada , Malhan Hafiz , Motabi Ibraheem , Al Farsi Khalil , Alshuaibi Mohammed , Siddiqui Mustaqeem , Ghonema Rasha , Taha Ruba Yasin , Abouzeid Tarek , Ahmed Wesam , Diab Mohanad , Alhuraiji Ahmad , Rabea Magdy , Chouikrat Mohamed Zahir
Published: April 2024

Background

Multiple myeloma (MM) is the second-most common cancer among hematological malignancies. Patients with active disease may experience several comorbidities, including renal insufficiency and asthma, which may lead to treatment failure. The treatment of relapsed or refractory MM (RRMM) has been associated with multiple factors, causing a decline in progression-free survival as well as overall survival with subsequent lines of therapy. Data about the characteristics of this group of patients in the Greater Gulf region are lacking.

Objective

The primary objective of this study is to describe the disease characteristics and various treatment approaches or regimens used in the management of patients with RRMM in the Greater Gulf region.

Methods

We will conduct a regional, retrospective study collecting real-world and epidemiological data on patients with MM in countries of the Greater Gulf region. Medical records will be used to obtain the required data. Around 150 to 170 patients’ records are planned to be retrospectively reviewed over 6 months without any cross-sectional or prospective intervention. Cases will be collected from Saudi Arabia, the United Arab Emirates, Kuwait, Oman, and Qatar. Descriptive as well as analytical statistics will be performed on the extracted data. The calculated sample size will allow us to estimate the percentages of RRMM cases with acceptable precision while complying with the challenges in light of data scarcity. We will obtain a comprehensive description of the demographic profile of patients with MM; treatment outcomes; the proportion of patients with MM with renal impairment and asthma, chronic obstructive pulmonary disease, or both at the time of diagnosis and any subsequent point; and data related to treatment lines, regimens, and MM-associated morbidities.

Results

Patient medical records were reviewed between June 2022 and January 2023 for eligibility and data extraction. A total of 148 patients were eligible for study inclusion, of whom 64.2% (n=95) were male and 35.8% (n=53) were female. The study is currently in its final stages of data analysis. The final manuscript is expected to be published in 2024.

Conclusions

Although MM is a predominant hematological disease, data on its prevalence and patients’ characteristics in the Greater Gulf region are scarce. Therefore, this study will give us real-world insights into disease characteristics and various management approaches of patients with MM in the Greater Gulf region.

International Registered Report Identifier (IRRID)

DERR1-10.2196/49861
Validating the Effectiveness of the Patient-Centered Cancer Care Framework by Assessing the Impact of Work System Factors on Patient-Centered Care and Quality of Care: Interview Study With Newly Diagnosed Cancer Patients (Preprint)
Authors: Elkefi Safa , Asan Onur
Published: April 2024

BACKGROUND

Patients with cancer who have recently been diagnosed have distinct requirements compared to cancer survivors. It is crucial to take into account their unique needs to ensure that they make informed decisions and are receptive to the care provided.

OBJECTIVE

This study suggested a framework titled Effectiveness of Patient-Centered Cancer Care that considers the needs of newly diagnosed patients with cancer and related work system factors. This study investigated how work system factors influence the perceptions of patient-centered care, quality of care, and associated outcomes among newly diagnosed patients with cancer. Patient-centered care is defined in terms of workload and communication considerations, whereas the quality of care is assessed through indicators such as trust in physicians, satisfaction with care, and perceptions of technology.

METHODS

This study used qualitative data collected through interviews with newly diagnosed patients with cancer (N=20) right after their first visits with their physicians. Thematic analysis was conducted to validate the 5 hypotheses of the framework, mapping the interactions among quality of care, patient-centered care, and work system factors.

RESULTS

We found that workload and patient-centered communication impact the quality of care and that the work system elements impact the patient-centeredness (workload and communication) and the quality of care (trust in physicians, satisfaction with care, and perception of technology use).

CONCLUSIONS

Qualitatively validating the proposed Effectiveness of Patient-Centered Cancer Care framework, this study demonstrated its efficacy in elucidating the interplay of various factors. The framework holds promise for informing interventions geared toward enhancing patients’ experiences during their initial visits after diagnosis. There is a pressing need for heightened attention to the organizational design, patient processes, and collaborative efforts among diverse stakeholders and providers to optimize the overall patient experience.
Cancer Care Supportive Text Messaging Program (Text4Hope) for People Living With Cancer and Their Caregivers During the COVID-19 Pandemic: Longitudinal Observational Study (Preprint)
Authors: Shalaby Reham , Vuong Wesley , Agyapong Belinda , Gusnowski April , Surood Shireen , Agyapong Vincent
Published: April 2024

BACKGROUND

Cancer is the leading cause of death in Canada, and living with cancer generates psychological demands, including depression and anxiety among cancer survivors and caregivers. Text4Hope-Cancer Care SMS text messaging–based service was provided to people with cancer and caregivers during the COVID-19 pandemic to support their mental health.

OBJECTIVE

The aim of this study is to examine the clinical effectiveness of and satisfaction with Text4Hope-Cancer Care in addressing mental health conditions among people living with cancer and caregivers.

METHODS

The study was conducted in Alberta, Canada. People who were diagnosed or receiving cancer treatment and caregivers self-subscribed to receive 3-months daily supportive cognitive behavioral therapy–based SMS text messages and a web-based survey was sent at designated time points to collect clinical and nonclinical data. The Hospital Anxiety and Depression scale (HADS) was used to examine changes in anxiety and depression symptoms after receiving the service. Satisfaction with the service was assessed using a survey with a Likert scale. Descriptive and inferential statistics were used, and test significance was considered with P≤.05.

RESULTS

Overall, 107 individuals subscribed to the service, and 93 completed the program (completion rate 93/107, 86.9%). A significant improvement in the anxiety symptoms (HADS-Anxiety [HADS-A] subscale) was reported after 3 months of Text4Hope-Cancer Care (t11=2.62; P=.02), with medium effect size (Hedges g=0.7), but not depression symptoms (HADS-Depression [HADS-D] subscale). Subscribers expressed high satisfaction and agreed that the service has helped them to cope with mental health symptoms and improve their quality of life. Most subscribers read the SMS text messages more than once (30/30, 100%); took time to reflect or took a beneficial action after reading the messages (27/30, 90%); and highly agreed (27/30, >80%) with the value of the received supportive SMS text messages as being relevant, succinct, affirmative, and positive. All subscribers recommended SMS text messaging for stress, anxiety, and depression and for cancer care support (30/30, 100%).

CONCLUSIONS

Text4Hope-Cancer Care was well-perceived and effectively addressed anxiety symptoms among people living with cancer and caregivers during the peak of the COVID-19 pandemic. This study provides evidence-based support and insight for policy and stakeholders to implement similar convenient, economic, and accessible mental health services that support vulnerable populations during crises.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/20240
Technological Adjuncts to Streamline Patient Recruitment, Informed Consent, and Data Management Processes in Clinical Research: Observational Study (Preprint)
Authors: Koh Jodie , Caron Stacey , Watters Amber N , Vaidyanathan Mahesh , Melnick David , Santi Alyssa , Hudson Kenneth , Arguelles Catherine , Mathur Priyanka , Etemadi Mozziyar
Published: April 2024

BACKGROUND

Patient recruitment and data management are laborious, resource-intensive aspects of clinical research that often dictate whether the successful completion of studies is possible. Technological advances present opportunities for streamlining these processes, thus improving completion rates for clinical research studies.

OBJECTIVE

This paper aims to demonstrate how technological adjuncts can enhance clinical research processes via automation and digital integration.

METHODS

Using one clinical research study as an example, we highlighted the use of technological adjuncts to automate and streamline research processes across various digital platforms, including a centralized database of electronic medical records (enterprise data warehouse [EDW]); a clinical research data management tool (REDCap [Research Electronic Data Capture]); and a locally managed, Health Insurance Portability and Accountability Act–compliant server. Eligible participants were identified through automated queries in the EDW, after which they received personalized email invitations with digital consent forms. After digital consent, patient data were transferred to a single Health Insurance Portability and Accountability Act–compliant server where each participant was assigned a unique QR code to facilitate data collection and integration. After the research study visit, data obtained were associated with existing electronic medical record data for each participant via a QR code system that collated participant consent, imaging data, and associated clinical data according to a unique examination ID.

RESULTS

Over a 19-month period, automated EDW queries identified 20,988 eligible patients, and 10,582 patients received personalized email invitations. In total, 1000 (9.45%) patients signed consents to participate in the study. Of the consented patients, 549 unique patients completed 779 study visits; some patients consented to the study at more than 1 time period during their pregnancy.

CONCLUSIONS

Technological adjuncts in clinical research decrease human labor while increasing participant reach and minimizing disruptions to clinic operations. Automating portions of the clinical research process benefits clinical research efforts by expanding and optimizing participant reach while reducing the limitations of labor and time in completing research studies.
From Fax to Secure File Transfer Protocol: The 25-Year Evolution of Real-Time Syndromic Surveillance in England (Preprint)
Authors: Elliot Alex J , Hughes Helen E , Harcourt Sally E , Smith Sue , Loveridge Paul , Morbey Roger A , Bains Amardeep , Edeghere Obaghe , Jones Natalia R , Todkill Daniel , Smith Gillian E
Published: April 2024

UNSTRUCTURED

The purpose of syndromic surveillance is to provide early warning of public health incidents, real-time situational awareness during incidents and emergencies, and reassurance of the lack of impact on the population, particularly during mass gatherings. The United Kingdom Health Security Agency (UKHSA) currently coordinates a real-time syndromic surveillance service that encompasses 6 national syndromic surveillance systems reporting on daily health care usage across England. Each working day, UKHSA analyzes syndromic data from over 200,000 daily patient encounters with the National Health Service, monitoring over 140 unique syndromic indicators, risk assessing over 50 daily statistical exceedances, and taking and recommending public health action on these daily. This English syndromic surveillance service had its origins as a small exploratory pilot in a single region of England in 1999 involving a new pilot telehealth service, initially reporting only on “cold or flu” calls. This pilot showed the value of syndromic surveillance in England, providing advanced warning of the start of seasonal influenza activity over existing laboratory-based surveillance systems. Since this initial pilot, a program of real-time syndromic surveillance has evolved from the single-system, -region, -indicator pilot (using manual data transfer methods) to an all-hazard, multisystem, automated national service. The suite of systems now monitors a wide range of syndromes, from acute respiratory illness to diarrhea to cardiac conditions, and is widely used in routine public health surveillance and for monitoring seasonal respiratory disease and incidents such as the COVID-19 pandemic. Here, we describe the 25-year evolution of the English syndromic surveillance system, focusing on the expansion and improvements in data sources and data management, the technological and digital enablers, and novel methods of data analytics and visualization.
Authors' Reply: Commentary on “Protecting User Privacy and Rights in Academic Data-Sharing Partnerships: Principles From a Pilot Program at Crisis Text Line” (Preprint)
Authors: Pisani Anthony R , Gallo Carlos , Gould Madelyn S , Kanuri Nitya , Marcotte John E , Pascal Brian , Rousseau David , Ranney Megan L , Filbin Bob , Turner Shairi
Published: April 2024

UNSTRUCTURED

We appreciate Reierson’s thoughtful commentary on our 2019 paper, which described our experiences, ethical process, judgment calls, and lessons from a 2016-2017 data-sharing pilot between Crisis Text Line and academic researchers. The commentary raises important questions about the ethical conduct of health research in the digital age, particularly regarding informed consent, potential conflicts of interest, and the protection of vulnerable populations. Our article focused specifically on the noncommercial use of Crisis Text Line data for research purposes, so we restrict our reply to points relevant to such usage. While we acknowledge the limitations of Crisis Text Line’s Terms of Service as a means of informing users about data sharing for research, we maintain that our guidelines were ethically sound and aligned with well-established practices for institutional review board (IRB) review and researcher training. We emphasize the critical role of IRBs in ensuring that research involving vulnerable populations, including minors, is conducted ethically and with appropriate safeguards. Regarding potential conflicts of interest, we argue that unpaid, nonfiduciary advisory board service for a nonprofit organization does not constitute a conflict requiring disclosure. The transparent nature of our collaboration with Crisis Text Line, as evidenced by the authorship and acknowledgments in our paper, further underscores our commitment to ethical research practices. We recognize the complexity and evolving nature of the challenges surrounding data-sharing partnerships in digital health research. As the field progresses, we remain committed to ongoing, transparent engagement and to refining best practices in collaboration with colleagues, stakeholders, and the public. Our response aims to provide clarity and context for the concerns raised in the commentary while reaffirming the integrity and value of our original work. Ultimately, we maintain that our paper contributed meaningfully to the ongoing discourse on ethical data sharing and laid the groundwork for future improvements in this critical area of digital health research.
Integrating Patient-Generated Digital Data into Mental Health Therapy: A mixed methods analysis of user experience (Preprint)
Authors: Southwick Lauren , Sharma Meghana , Rai Sunny , Beidas Rinad S. , Mandell David S. , Asch David A. , Curtis Brenda , Guntuku Sharath Chandra , Merchant Raina M.
Published: April 2024

UNSTRUCTURED

Therapists and their patients increasingly discuss digital data from social media, smartphone sensors, and other online engagement within the context of psychotherapy. We examined patients’ and mental health therapists’ experiences and perceptions following a randomized controlled trial (RCT) in which they both received regular summaries of patients’ digital data (e.g., dashboard) to review and discuss in session. The dashboard included data which patients consented to share from their social media posts, phone usage and online searches. Following the RCT, patient (n=56) and therapist (n=44) participants completed a debriefing survey after their study completion (from December 2021 - January 2022). Participants were asked about their experience receiving a digital data dashboard in psychotherapy via closed- and open-ended questions. We calculated descriptive statistics for closed-ended questions and conducted qualitative coding via NVivo 10 and natural language processing using the machine learning tool Latent Dirichlet Allocation to analyze open-ended questions. Of 100 participants, nearly half (49%) described their experience with the dashboard as “positive,” while the other half noted a “neutral” experience. Responses to the open-ended questions resulted in three thematic areas (9 sub-categories): (1) dashboard experience (positive; neutral or negative; comfortable), (2) perception of the dashboard’s impact on enhancing therapy (accountability; increased awareness over time; objectivity), and (3) dashboard refinements (additional sources; tailored content; ethics). Patients reported that receiving their digital data helped them stay “accountable,” while therapists indicated that dashboard helped “tailor treatment plans.” Patient and therapist surveys provided important feedback their experience regularly discussing dashboards in psychotherapy.
A dashboard for managing an eco-system and people with dementia: the HAAL study protocol. (Preprint)
Authors: Amabili Giulio , Maranesi Elvira , Barbarossa Federico , Margaritini Arianna , Bonfigli Anna Rita , Su Fong-Chin , Lin Chien-Ju , Chieh Hsiao-Feng , Vasseur Dianne , Nap Henk Herman , Hsu Yeh-Liang , Bai Dorothy , Bevilacqua Roberta
Published: April 2024

UNSTRUCTURED

Dementia is a syndrome characterized by a wide spectrum of symptoms and needs. There is no cure for this syndrome that represents a major challenge to society in terms of quality of life for those affected, and in terms of workload and stress burden for those who take care of them. The HAAL project aims to improve quality of life of both people with dementia and their formal and informal caregivers, by providing a personalized set of devices to the person with dementia, along with a dashboard designed for carers to monitor and manage the older person. The HAAL eco-system consists of a dashboard which integrates, aggregates, and analyses heterogeneous data gathered from different devices designed for and tested with people with dementia. The study is designed as a technical feasibility pilot to test the HAAL eco-system in three countries: Italy, the Netherlands, and Taiwan. The primary interest is to assess the impact of the HAAL platform on caregivers’ workload and end users’ quality of life, that will be measured through ZARIT, GAD-7 and EQ-5D scales. Then, the field trials also focus on the usability of the HAAL ecosystem, evaluated through the SUS scale. The HAAL field trial, is an innovative feasibility study focused on the impact of a complex technological ecosystem designed for people with dementia and their caregivers. The HAAL eco-system aims to relief stress at work for formal and informal caregivers, to improvein the perceived quality of life for informal caregivers and person with dementia, and to reduce the care load for the formal caregivers.
Microbial Marvels in Cotton Farming: Unveiling the Potential of Plant Beneficial Microbes for Enhanced Growth and Disease Resistance in Pakistan
Authors: Ahmad Hafiz Tanvir , Iqbal Muhammad
Published: April 2024

Cotton is a crucial cash crop in Pakistan, playing a pivotal role in the country's economy, agricultural sector, and employment opportunities. Its cultivation spans over 3 million hectares, primarily concentrated in the Punjab and Sindh provinces. Cotton production in Pakistan contributes significantly to the country's foreign exchange earnings, accounting for a substantial portion of its exports However, cotton pest and disease management is always a challenge as their impact change over time. The widespread use of agrochemicals and synthetic pesticides in major field crops poses significant threats to human and animal health, as well as environmental degradation. Use of beneficial microbes for sustainable cotton production can be a natural ally in the field, as they promote the plant growth as well as protect them from disease, insects and pests. They act as a reservoir of beneficial metabolites, enzymes, and nutrients, and they play a crucial role in biological pest control and disease resistance induction. Additionally, PGP rhizobacteria possess bioremediation potential, enabling them to phytoextract and detoxify pollutants and pesticides. Beneficial microorganisms like PGPR hold immense potential to replace and supplement these toxic chemicals, offering promising applications in organic farming and contributing to sustainable agricultural practices. Despite their potential, only a limited number of bio-formulations have been developed using PGPR strains with plant growth promotion, metabolite production, enzyme synthesis, nutrient mobilization, and biocontrol activities. An increasing body of evidence underscores the potential of diverse microorganisms to enhance plant productivity and yield within cropping systems. Unlocking the full benefits of these advantageous microbes requires a profound understanding of their role in promoting growth, specifically in the realms of fertilization and disease control, along with the elucidation of underlying mechanisms. It is imperative to confront challenges associated with the application of plant growth-promoting (PGP) microbes. This review focuses on the application of PGP microbes in the context of cotton production. Given the scarcity of information on beneficial microbes for cotton production, a comprehensive examination of current research becomes crucial, especially given the increasing interest in cotton inoculants, particularly in developing nations. The heightened attention towards PGP applications underscores the importance of advancing sustainable agricultural practices.
Los estereotipos en el capitalismo gore: la rentabilidad de la violencia en la serie de Netflix Narcos (2015)
Authors: Hurtado Cadavid John Jaime
Published: April 2024

Este artículo analiza la explotación de los estereotipos de la cultura colombiana en la serie Narcos (2015) producida y difundida por Netflix. La pregunta central es cómo el uso de los estereotipos del colombiano narco y violento se convierte en fuente fundamental para elaborar proyectos cinematográficos rentables, e impulsar dicho estereotipo a nivel mundial gracias a las plataformas de streaming como Netflix. Para ello se parte de un análisis conceptual sobre la formación de los estereotipos que dividen poblaciones entre los “normales” y los indeseables (quienes poseen una marca o estigma social) y su uso en producciones con imágenes de violencia espectacular que convierten las narcoseries en representantes del capitalismo gore. Luego, se describen algunas escenas de la serie de televisión para ejemplificar los usos de los estereotipos colombianos que, mezclados con elementos de la fascinante violencia, posibilitan la creación de un lenguaje que potencializa los estereotipos iniciales. Para concluir, se plantea la importancia y necesidad de generar espacios académicos de debate para construir una sistematización de saberes que conduzcan a la evolución de conocimiento alrededor de los usos de la violencia y la formación de estereotipos como lenguajes con la capacidad de pegarse y transmitirse a través de la industria cultural cinematográfica.
Soberanía monetaría, desarrollo y pensamiento económico latinoamericano: enseñanzas de la dolarización ecuatoriana
Authors: Meireles Monika
Published: April 2024

En un momento en el que el ciclo de los gobiernos progresistas en América Latina se encuentra en jaque, analizar los limitantes y potencialidades de la Revolución Ciudadana en Ecuador recobra significado. La contradicción que hay entre la continuidad del manejo monetario conservador -formalmente dolarizado- por parte de un gobierno que se comprometió de forma pública con la transformación social radical y el impulso a una estrategia alternativa de desarrollo demanda una reflexión más profunda. El debate sobre las distintas concepciones de gestión monetaria y de sus articulaciones con el proceso de desarrollo económico recobra aliento, haciendo legítimo el esfuerzo condensado en este libro. Así, a la luz de la experiencia ecuatoriana, el objetivo principal del presente trabajo es discutir las vías más prometedoras para la actualización del pensamiento económico latinoamericano dedicado a debatir los rumbos del desarrollo de la región en el siglo XXI, justamente a partir de la incorporación de la discusión sobre la naturaleza del dinero en clave heterodoxa.
Patient Sickness Prediction Model
Authors: Sharma Piyush , Soni Abhijeet , Gupta Ayushi , Shukla Samiksha
Published: April 2024

Abstract: The realm of healthcare constantly seeks innovative methods to improve patient care and outcomes. The advent of predictive analytics in healthcare has opened new avenues for preemptive diagnosis and treatment strategies. This paper introduces a novel Patient Sickness Prediction System (PSPS), designed to leverage machine learning algorithms and big data analytics for early detection of potential health issues. By integrating electronic health records (EHRs), real-time health monitoring data, and patient history, the PSPS aims to provide healthcare professionals with actionable insights, facilitating timely and personalised care. This research explores the system's development, implementation strategies, and its potential impact on healthcare delivery and patient outcomes.
Saber del cuerpo, saber con el cuerpo: la comunicación de la salud desde una ética del cuidado
Authors: Cabral Ximena Irene , Drazile Natalia , Mendizábal Victoria
Published: April 2024

La pandemia de COVID-19 generó una crisis mundial que puso en tensión distintos planos de la existencia humana. En el plano de la salud, el modelo biomédico hegemónico imperó en los modos de explicar y ofrecer soluciones; sin embargo, su mirada biologicista resultó insuficiente, lo cual habilitó preguntas y reflexiones sobre la dimensión sociohistórica y situada de los cuerpos y puso en tela de juicio las formas de producción capitalista en sus vínculos con lo viviente. En este artículo se realiza una revisión crítica del modelo biomédico para, luego, dialogar desde los aportes de otros campos de conocimiento en lo que respecta a otros modos de pensar los cuerpos, desde los cuerpos y su relación con lo viviente. Se considera que, desde una comprensión densa y vitalista del concepto de salud, e incorporando algunas miradas desde el cuidado y debates feministas, se pueden construir otras tramas para pensar la comunicación en este campo.
COMPARISON ANALYSIS OF THE EFFECTIVENESS OF GRANISETRON AND PALONOSETRON PREMEDICATION ON PONV EVENTS IN LAPARASCOPY PATIENT
Authors: Kuncoro Daviet Dwi , Sumarny Ros , Arozal Wawaimuli , Kapuangan Christopher
Published: April 2024

Post Operative Nausea and Vomiting (PONV) adalah efek samping yang paling umum ditemukan setelah tindakan pembedahan dengan anestesi umum. Pada operasi laparaskopi insiden PONV dialami oleh 50%-70% pasien. Skor Apfel adalah salah satu prediktor PONV yang dapat digunakan untuk memprediksi tingkat risiko PONV pada pasien. Granisetron dan palonosetron digunakan untuk premedikasi antiemetik pada kejadian mual dan muntah pasca operasi. Penelitian ini bertujuan untuk menganalisis perbedaan efektivitas antara granisetron dengan palonosetron terhadap kejadian mual dan muntah fase awal (0-2 jam pasca operasi) dan fase terlambat (2-24 jam pasca operasi) pada pasien pasca operasi laparaskopi yang berisiko tinggi mengalami PONV. Penelitian ini merupakan penelitian kohort prospektif mengikutsertakan 62 pasien mendapat granisetron dan 62 pasien mendapat palonosetron kategori risiko tinggi skor apfel sedangkan signifkansi perbedaan efektivitas dianalisa menggunakan metode Chi-square. Variabel bebas adalah antiemetik granisetron dan palonosetron (intravena) dan variabel tergantung adalah kejadian mual dan muntah pasca operasi. Hasil analisis menunjukkan palonosetron lebih efektif secara bermakna dari granisetron dalam mencegah mual muntah fase awal dan fase terlambat setelah operasi laparaskopi.
A Review on Banned Drugs
Authors: Vaishnavi S Ghodake , Sachin Hangargekar , Priyanka D Yelkote , Mohini A Gurav , Ayesha N Siddique , Madhav Honrao , Sante Rohini , Madhuri. Phulari
Published: April 2024

India has become a hub for the availability and usage of banned or harmful medicines such as Nimesulide, D’cold, Novalgin, Lomofen, and Rofecoxib, among others. The decision to ban a drug is based on the risk versus benefit ratio evaluated through post-marketing surveillance and the Adverse Drug Reaction Reporting System. Pharmaceutical negligence among doctors can lead to hazardous effects on the general health of a patient. It is important for the government to spread information on drugsideeffects. The prescribing of drugs is an essential practice for medical professionals. In promoting a healthy lifestyle, the prevention of diseases is important, but equally important is treatment of such diseases with safe drugs. Every drug has some side effects, but with the correct dosage, it can be avoided. Banned drugs have more adverse/side effects. Drugs that are found unsafe in post-marketing surveillance are banned by regulatory authorities. The Drug Controller General of India (DCGI) is the highest authority in India to approve or ban a drug. Despite this, banned drugs are still available in developing countries such as India due to a lack of law enforcement, physician awareness, and drug control authorities failing to inform hospitals of the status of medicine. India is a major hub for banned drugs.
Analisis Perilaku Air Di Perkebunan Kelapa Sawit Pada Tanah Spodosol dan Ultisol Menggunakan Soil Moisture Content Monitoring System (SMCMS)
Authors: Sukarman Sukarman , Sutiarso Lilik , Suwardi Suwardi , Wirianata Herry , Prima Nugroho Andri , Primananda Septa , Syarovy Muhdan , Pradiko Iput , Hijri Darlan Nuzul
Published: April 2024

Ketersediaan air merupakan aspek yang sangat penting agar kelapa sawit dapat tumbuh dan berproduksi secara optimal. Tujuan penelitian ini adalah untuk menganalisis perilaku air melalui monitoring dinamika kelembaban dan suhu tanah menggunakan Soil Moisture Content Monitoring System (SMCMS). SMCMS terdiri atas sensor yang dipasang di lapangan dan sistem monitoring berbasis internet. SMCMS dipasang di perkebunan kelapa sawit pada tanah Ultisol (A), Spodosol dengan perlakuan pecah hardpan dan mounding (B), dan Spodosol tanpa perlakuan (C). Sensor kelembaban dan suhu tanah dipasang pada tiga kedalaman yang berbeda. Hasil menunjukkan bahwa SMCMS dapat beroperasi secara otomatis dan real-time dalam mengukur perilaku air. Berdasarkan hasil monitoring dan pengukuran, dapat diketahui bahwa kelembaban tanah tertinggi terdapat pada lokasi A dengan rerata 46,91%, kemudian diikuti lokasi B 38,40%, dan C yaitu 29,49%. Spodosol dengan perlakuan (B) memiliki suhu tanah terendah dengan rerata 27,36°C, kemudian diikuti Ultisol (A) 27,58°C, dan Spodosol kontrol (C) 28,40°C. Lebih lanjut, kelembaban tanah berkorelasi lemah dengan suhu tanah. Suhu tanah memiliki korelasi yang lemah dengan suhu udara. Sementara itu, kedua perilaku air tanah tersebut memiliki korelasi yang sangat lemah dengan variabel lingkungan, khususnya curah hujan.
ALTERNATIVE METHODOLOGY SIMULATING CAMERA LUCIDA FOR DRAWING MICROSCOPIC IMAGES
Authors: Espolador Leitão Carlos André , Simões Caires Claudenir
Published: April 2024

The camera lucida is an ancient equipment that is still used today to illustrate images through a microscope and stereomicroscope. Although it is not an overly expensive equipment, it can be inaccessible to some laboratories, and it has certain drawbacks that can be easily overcome with current technology. This work aimed at developing and testing a technique to replace the camera lucida. To this end, a microscope, a smartphone, a computer with a printer, and a light table made with low-cost materials were used, whose construction schemes are detailed in this work. A micrograph was obtained with the smartphone positioned in the microscope eyepiece. The micrograph was printed on an A4 paper sheet that was adhered to the light table, and, over the image, was placed a second paper sheet. With the light table turned on, the printed image became clearly visible on the blank paper sheet by transparency and could then be easily drawn. It is concluded that the technique described here allows excellent results, being an efficient alternative to the camera lucida in optical equipment.
Universidad, sociedad y territorio
Authors: Reques Velasco Pedro
Published: April 2024

Libro interdisciplinar colectivo en tres partes, de incuestionable rigor académico, cuya riqueza reside en su oportunidad. Nos muestra el pasado y presente de la Universidad española y pone las bases para ordenar, sistematizar y actualizar la información referente a nuestro sistema universitario procedente de fuentes muy variadas (CRUE, Consejo de Universidades…). A través de los ejemplos de buenas prácticas en las relaciones universidad-sociedad-territorio, en diferentes países europeos y americanos, permite abordar con más perspectiva y posibilidades de éxito los retos que representan el actual marco colaborativo europeo y el contexto universitario global.
Europa en torno a Utrecht
Authors: Torres Arce Marina , Truchuelo García Susana
Published: April 2024

Las paces de 1713-1715, que marcan el punto final de la guerra de sucesión española, trascienden en su significación histórica la cuestión sucesoria de la monarquía española, para erigirse en el momento de redefinición de algunas de las principales identidades territoriales y políticas que, hasta entonces, habían configurado las monarquías de Europa occidental y para convertirse en símbolo del surgimiento de un nuevo orden internacional. El significado histórico de Europa en torno a Utrecht constituye la materia que ocupa este libro, que es abordada, de forma compleja, por quince especialistas procedentes de distintas universidades europeas. Sus reflexiones e interpretaciones permiten avanzar en nuestra comprensión histórica de esa fase que marcó el inicio del siglo XVIII en la Europa continental y en sus proyecciones en el Nuevo Mundo, desde una perspectiva revisionista del estado de la cuestión, tanto global como multidisciplinar. Este período se manifiesta como un eslabón en el largo proceso de construcción europea que había comenzado a perfilarse desde principios de la Edad Moderna. Europa en torno a Utrecht se presenta como una herramienta útil tanto para el público interesado en la historia de Europa, en general, como para el estudioso universitario. Este libro ha sido concebido para poder emplearse como un manual universitario con material de apoyo, tanto para el docente como para el estudiante de Grado, Máster y Doctorado en el que, a las distintas reflexiones que constituyen cada uno de los capítulos, se incorporan una bibliografía básica del tema y un documento final, de naturaleza textual, cartográfica o artística, para complementar la interpretación y valoración de los contenidos desarrollados en cada ensayo.
FACTORS ASSOCIATED WITH BREASTFEEDING INTENTION AMONG GESTATIONAL DIABETES MELLITUS MOTHERS
Authors: Zainorin Nur Izzatie , Abdul Hamid Syahrul Bariah , Shuhaimi Farhanah Ahmad , Nasution Zuraidah
Published: April 2024

Breastfeeding knowledge, self-efficacy, attitude and breastfeeding intention affect breastfeeding rates, especially in mothers with Gestational Diabetes Mellitus (GDM) who are associated with having poor breastfeeding outcomes. Therefore, this study is aimed to investigate whether breastfeeding knowledge, attitude, self-efficacy, and sociodemographic factors are associated with breastfeeding intention among GDM pregnant mothers attending health clinics in Selangor. Validated questionnaires including Breastfeeding Self-Efficacy Scale Short Form (BSES-SF), Knowledge and Attitude, Breastfeeding Questionnaire (KA-BFQ), and Infant Feeding Intention (IFI) were self-administered to assess maternal knowledge, attitude, self-efficacy, and intention towards breastfeeding. Pearson’s Chi Square and independent t-test were used to investigate factors associated with breastfeeding intention among GDM mothers. Multiple linear regression was executed to explore determinants of breastfeeding intention among the studied population. A total of 124 pregnant women with GDM visiting chosen public health clinics in Selangor were recruited for this study. Findings revealed the scores (Mean ± SD) for breastfeeding knowledge 25.66 ± 8.736, breastfeeding attitude 81 ± 11.5, and breastfeeding self-efficacy 48.5 ± 12. About 84.7% (n = 105) had the intention to breastfeed with a mean score of 11 ± 5.25. Further analysis depicted significant associations between breastfeeding intention with a family history of diabetes (AOR = 3.551, 95% CI: 1.127 to 11.185, p-value = 0.030) and breastfeeding knowledge (AOR = 1.107, 95% CI: 1.036 to 1.182, p-value = 0.003). This study concluded that mothers with GDM had fair breastfeeding knowledge, good attitude, high self-efficacy, and high intention in breastfeeding. These findings highlight the need to develop culture-specific interventions in improving breastfeeding knowledge particularly to enhance breastfeeding intention among GDM mothers.
Evaluating Student Clerkship Performance Using Multiple Assessment Components
Authors: Oki Oladimeji , Naqvi Zoon , Jordan William , Guilliames Conair , Archer-Dyer Heather , Santos Maria Teresa
Published: April 2024

Introduction: Family medicine clerkships utilize a broad set of objectives. The scope of these objectives cannot be measured by one assessment alone. Using multiple assessments aimed at measuring different objectives may provide more holistic evaluation of students. A further concern is to ensure longitudinal accuracy of assessments. In this study, we sought to better understand the relevance and validity of different assessment tools used in family medicine clerkships.
Methods: We retrospectively correlated family medicine clerkship students’ scores across different assessments to evaluate the strengths of the correlations, between the different assessment tools. We defined ρ<0.3 as weak, ρ>0.3 to ρ<0.5 as moderate, and ρ>0.5 as high correlation.
Results: We compared individual assessment scores for 267 students for analysis. The correlation of the clinical evaluation was 0.165 (P<.01); with case-based short-answer questions it was 0.153 (P<.01); and with objective structured clinical examinations it was -0.246 (P<0.01).
Conclusion: Overall low levels of correlations between our assessments are expected, as they are each designed to measure different objectives. The relatively higher correlation between component scores supports convergent validity while correlations closer to zero suggest discriminant validity. Unexpectedly, comparing the multiple-choice questions and objective, structured clinical encounter (OSCE) assessments, we found higher correlation, although we believe these should measure disparate objectives. We replaced our in-house multiple-choice questions with a nationally-standardized exam and preliminary analysis shows the expected weaker correlation with the OSCE assessment, suggesting periodic correlations between assessments may be useful.
Variation of parameters and initial time difference Lipschitz stability of impulsive differential equations
Authors: DEMİRBÜKEN Saliha , Yakar Coşkun
Published: April 2024

In this paper, we investigate the Lipschitz stability of a perturbed
impulsive differential system concerning the unperturbed system. We
employ the variation of parameters or the constant of variation for
impulsive differential systems with an initial time difference.
Green Preference, Green Investment
Authors: Gao Zhenyu , Luo Yan , Tian Shu , Yang Hao
Published: April 2024

This paper examines whether individual investors’ green preference will be reflected in their investment decisions. It provides compelling evidence that individuals with stronger green preference invest more in green mutual funds, influenced by concerns over the physical and regulatory risks of climate change. It suggests that this behavior is not driven by financial incentives as preference-related investments may not always lead to financial gains from trading.
Nonfungible Tokens—Differentiated Crypto Assets in Need of Accounting and Attestation Guidelines; Analysis and Implications
Authors: Kinory Ethan , Stein Smith Sean
Published: April 2024

Even as recent headlines announce the risks of crypto assets, institutional and governmental adoption continues. Undeterred by short-term price declines and liquidation of speculative instruments, blockchain-based instruments and applications continue to receive billions in investment across the globe. And yet, accounting and attestation standards have failed to keep pace with this growth. This paper focuses specifically on the development of one type of crypto asset—nonfungible tokens (NFTs)—and the relevant accounting and auditing concerns. The first section reviews the nature of NFTs, differentiating them from other existing crypto assets. The second section examines factors that must be considered for the audit and attestation of NFTs. This paper raises questions that both the academician and practitioner must contend with as these crypto assets continue to be adopted.