bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrical Performance Analysis of High-Speed Interconnection and Power Delivery Network (PDN) in Low-Loss Glass Substrate-Based Interposers
Authors: Kim Youngwoo
Published: October 2023

In this article, electrical performance analysis of high-speed interconnection and power delivery network (PDN) in low-loss glass substrate-based interposers is conducted considering signal integrity (SI) and power integrity (PI). The low-loss glass substrate is a superior alternative to silicon substrate in terms of high-speed signaling and fabrication yield. However, the low-loss of the substrate is vulnerable to power/ground noise in the PDN since the low-loss property of the substrate cannot suppress the noise naturally. In this article, an in-depth electrical performance analysis is conducted based on various measurements and simulations to fully benefit the advantages of the low-loss glass substrate. First, the fabrication process and test vehicles for the analysis are explained. Using the test vehicles, the electrical performance of the glass interposer’s high-speed interconnection is compared with those of silicon and organic interposers. The insertion loss, eye-diagrams, and signal bandwidths of three interposer channels are compared and analyzed based on electromagnetic (EM) and circuit simulations. Also, the electrical performance of the through glass via (TGV) channel is measured and compared with through silicon via (TSV) channel. The high-speed interconnection of the glass interposer showed better performance for most of the parameters which is more suitable for maintaining the SI. Even though the low-loss of the glass substrate ensured the SI, power/ground noise issues in the PDN must be analyzed and solved. In this article, various cases inducing the power/ground noise in the PDN are considered, simulated, and measured. To solve the issues, ground TGV design and electromagnetic bandgap (EBG) design are proposed for an efficient broadband suppression of the noise generated in the glass interposer PDN.
Biosynthesis of Copper Nanoparticles with Medicinal Plants Extracts: From Extraction Methods to Applications
Authors: Antonio-Pérez Aurora , Durán-Armenta Luis Fernando , Pérez-Loredo María Guadalupe , Torres-Huerta Ana Laura
Published: October 2023

Copper nanoparticles (CuNPs) can be synthesized by green methods using plant extracts. These methods are more environmentally friendly and offer improved properties of the synthesized NPs in terms of biocompatibility and functional capabilities. Traditional medicine has a rich history of utilization of herbs for millennia, offering a viable alternative or complementary option to conventional pharmacological medications. Plants of traditional herbal use or those with medicinal properties are candidates to be used to obtain NPs due to their high and complex content of biocompounds with different redox capacities that provide a dynamic reaction environment for NP synthesis. Other synthesis conditions, such as salt precursor concentration, temperature, time synthesis, and pH, have a significant effect on the characteristics of the NPs. This paper will review the properties of some compounds from medicinal plants, plant extract obtention methods alternatives, characteristics of plant extracts, and how they relate to the NP synthesis process. Additionally, the document includes diverse applications associated with CuNPs, starting from antibacterial properties to potential applications in metabolic disease treatment, vegetable tissue culture, therapy, and cardioprotective effect, among others.
Spin Polarization and Flat Bands in Eu-Doped Nanoporous and Twisted Bilayer Graphenes
Authors: Melchakova Iu. A. , Oyeniyi G. T. , Polyutov S. P. , Avramov P. V.
Published: October 2023

Advanced two-dimensional spin-polarized heterostructures based on twisted (TBG) and nanoporous (NPBG) bilayer graphenes doped with Eu ions were theoretically proposed and studied using Periodic Boundary Conditions Density Functional theory electronic structure calculations. The significant polarization of the electronic states at the Fermi level was discovered for both Eu/NPBG(AA) and Eu/TBG lattices. Eu ions’ chemi- and physisorption to both graphenes may lead to structural deformations, drop of symmetry of low-dimensional lattices, interlayer fusion, and mutual slides of TBG graphene fragments. The frontier bands in the valence region at the vicinity of the Fermi level of both spin-polarized 2D Eu/NPBG(AA) and Eu/TBG lattices clearly demonstrate flat dispersion laws caused by localized electronic states formed by TBG Moiré patterns, which could lead to strong electron correlations and the formation of exotic quantum phases.
Analysis of SiC/Si Heterojunction Band Energy and Interface State Characteristics for SiC/Si VDMOS
Authors: Yang Xin , Duan Baoxing , Yang Yintang
Published: October 2023

SiC/Si and GaN/Si heterojunction technology has been widely used in power semiconductor devices, and SiC/Si VDMOS and GaN/Si VDMOS were proposed in our previous paper. Based on existing research, breakdown point transfer technology (BPT) was used to optimize SiC/Si VDMOS. Simulation results showed that the BV of the SiC/Si heterojunction VDMOS was considerably increased from 259 V to 1144 V, and Ron,sp decreased from 18.2 mΩ·cm2 to 6.03 mΩ·cm2 compared with Si VDMOS. In order to analyze the characteristics of the SiC/Si heterojunction structure deeply, the influence of the interface state characteristics of the SiC/Si heterojunction on the electrical parameters of VDMOS was analyzed, including electric field characteristics, blocking characteristics, output characteristics, and transfer characteristics. In addition, the influence of the interface state of the SiC/Si heterojunction on energy band characteristics was analyzed. The results showed that with an increase in the interfacial charge (acceptor) concentration, the p-type trap layer was introduced into the interface of the SiC/Si heterojunction, energy increased slightly, and the barrier height difference at the heterojunction increased, resulting in an increase in BV. At the same time, since the barrier height became higher, electrons did not flow easily, so Ron,sp increased. On the contrary, when a charge (donor) was introduced at the interface of the SiC/Si heterojunction, the number of electrons in the channel increased, resulting in an increase in the electron current, which is conducive to the flow of electrons, resulting in a decrease in Ron,sp. The energy band and other characteristics of devices with temperature were simulated at different temperatures. Finally, the effects of SiC/Si heterojunction interface states on interface capacitances and switching performances of VDMOS devices were also discussed.
Design and Application of Memristive Balanced Ternary Univariate Logic Circuit
Authors: Wang Xiaoyuan , Zhang Xinrui , Dong Chuantao , Nath Shimul , Iu Herbert
Published: October 2023

This paper proposes a unique memristor-based design scheme for a balanced ternary digital logic circuit. First, a design method of a single-variable logic function circuit is proposed. Then, by combining with a balanced ternary multiplexer, some common application-type combinational logic circuits are proposed, including a balanced ternary half adder, multiplier and numerical comparator. The above circuits are all simulated and verified in LTSpice, which demonstrate the feasibility of the proposed scheme.
Reflection and Transmission Analysis of Surface Acoustic Wave Devices
Authors: Yu Tai-Ho
Published: October 2023

This paper presents a study of the propagation of surface acoustic waves in a single and periodic array of metal strip overlays on the surface of layered substrates. Responses of reflected and transmitted surface acoustic waves due to various geometric design parameters of the grating arrays are investigated. An eight-dimensional matrix formulation based on Stroh formalism is adopted to analyze wave propagation in piezoelectric layered media. The dispersion curves for aluminum–zinc oxide films on glass substrates are determined using the surface impedance tensor method. A transfer matrix in terms of the state vectors in cooperation with continuity conditions on the edges of the grating array is used to determine the reflectivity and transmittance of the horizontally propagating surface acoustic waves. The analysis and simulation results show that when the surface acoustic wave is obliquely incident on an array of gratings and the strip width is equal to the gap between strips, the constructive interference of the reflected wave occurs at odd multiples of the strip width to a wavelength ratio of 0.25. When the strip width is unequal to the gap, the constructive interference of the reflected wave is an odd multiple of the strip width to a wavelength ratio of 0.5. An increase in the number of strips concentrates the reflectivity’s extreme frequencies, and an increase in the strip height increases the bandwidth of the extreme frequencies. Both of these increases strengthen the reflected wave’s constructive interferences.
Long COVID-19 Pathophysiology: What Do We Know So Far?
Authors: Tziolos Nikolaos-Renatos , Ioannou Petros , Baliou Stella , Kofteridis Diamantis P.
Published: October 2023

Long COVID-19 is a recognized entity that affects millions of people worldwide. Its broad clinical symptoms include thrombotic events, brain fog, myocarditis, shortness of breath, fatigue, muscle pains, and others. Due to the binding of the virus with ACE-2 receptors, expressed in many organs, it can potentially affect any system; however, it most often affects the cardiovascular, central nervous, respiratory, and immune systems. Age, high body mass index, female sex, previous hospitalization, and smoking are some of its risk factors. Despite great efforts to define its pathophysiology, gaps remain to be explained. The main mechanisms described in the literature involve viral persistence, hypercoagulopathy, immune dysregulation, autoimmunity, hyperinflammation, or a combination of these. The exact mechanisms may differ from system to system, but some share the same pathways. This review aims to describe the most prevalent pathophysiological pathways explaining this syndrome.
Enhanced Anti-Herpetic Activity of Valacyclovir Loaded in Sulfobutyl-ether-β-cyclodextrin-decorated Chitosan Nanodroplets
Authors: Argenziano Monica , Arduino Irene , Rittà Massimo , Molinar Chiara , Feyles Elisa , Lembo David , Cavalli Roberta , Donalisio Manuela
Published: October 2023

Valacyclovir (VACV) was developed as a prodrug of the most common anti-herpetic drug Acyclovir (ACV), aiming to enhance its bioavailability. Nevertheless, prolonged VACV oral treatment may lead to the development of important side effects. Nanotechnology-based formulations for vaginal administration represent a promising approach to increase the concentration of the drug at the site of infection, limiting systemic drug exposure and reducing systemic toxicity. In this study, VACV-loaded nanodroplet (ND) formulations, optimized for vaginal delivery, were designed. Cell-based assays were then carried out to evaluate the antiviral activity of VACV loaded in the ND system. The chitosan-shelled ND exhibited an average diameter of about 400 nm and a VACV encapsulation efficiency of approximately 91% and was characterized by a prolonged and sustained release of VACV. Moreover, a modification of chitosan shell with an anionic cyclodextrin, sulfobutyl ether β-cyclodextrin (SBEβCD), as a physical cross-linker, increased the stability and mucoadhesion capability of the nanosystem. Biological experiments showed that SBEβCD-chitosan NDs enhanced VACV antiviral activity against the herpes simplex viruses type 1 and 2, most likely due to the long-term controlled release of VACV loaded in the ND and an improved delivery of the drug in sub-cellular compartments.
Microbial Relationship of Carious Deciduous Molars and Adjacent First Permanent Molars
Authors: Shi Weihua , Tian Jing , Xu He , Qin Man
Published: October 2023

(1) Epidemiological studies have shown that deciduous molar caries are related to and more severe than permanent molar caries. This study aimed to investigate whether caries subtypes in deciduous molars were associated with caries in first permanent molars and to explore taxonomic and functional profiles of the microbiota involved in different subtypes. (2) 42 mixed-dentition children were recruited and were divided into DMC (carious deciduous molars but caries-free first permanent molars; n = 14), C (carious deciduous and first permanent molars; n = 13), and control (n = 15) groups. Metagenomic sequencing was performed for supragingival plaque samples obtained separately from deciduous and first permanent molars. (3) The microbiota of deciduous molars in the DMC and C groups differed not only in species-based beta diversity but also in compositional and functional profiles. In the C group-like subtype, 14 caries-related species and potential pathways were identified that could be responsible for the caries relationship between the deciduous and permanent molars. In the DMC group-like subtype, the overall functional structure, the levels of Leptotrichia wadei, Streptococcus anginosus, and Stomatobaculum longum and KOs in sugar transporters and fermentation, quorum sensing, and TCA cycle in their first permanent molars surprisingly resembled those of the C group rather than the control group. This suggested that these clinically sound first permanent molars were at a greater risk for caries. (4) Classification of deciduous molar caries according to the microbiota could serve as a caries risk predictor for adjacent first permanent molars.
Lactobacillus helveticus Isolated from Raw Milk Improves Liver Function, Hepatic Steatosis, and Lipid Metabolism in Non-Alcoholic Fatty Liver Disease Mouse Model
Authors: Kim Hyeonji , Lee Kippeum , Kim Ju-Yeon , Shim Jae-Jung , Lim Junghyun , Kim Joo-Yun , Lee Jung-Lyoul
Published: October 2023

Here, we show that Lactiplantibacillus plantarum LP158 (LP158), Lactobacillus helveticus HY7804 (HY7804), and Lacticaseibacillus paracasei LPC226 (LPC226) isolated from raw milk alleviate non-alcoholic fatty acid disease (NAFLD) in a C57BL/6 mouse model. Lactic acid bacteria (LAB) were screened for their ability to inhibit fatty acid accumulation in palmitic acid (PA)-treated HepG2 cells, and three strains were selected based on the results. We also investigated hemolytic activity and antibiotic resistance of the three strains. LP158, HY7804, and LPC226 suppressed expression of mRNA encoding genes related to lipogenesis, and increased expression of genes related to β-oxidation, in a PA-induced HepG2 cell model. Moreover, when LP158, HY7804, and LPC226 were administered at 109 CFU/kg/day for 8 weeks to mice with dietary-induced NAFLD, they all modulated blood biochemistry markers and reduced steatosis in liver tissue. Also, all three strains significantly reduced expression of mRNA encoding lipogenesis genes (Fasn, Acaca, and Srebp-1c) and inflammatory factors (Tnfα and Ccl-2) and fibrosis factors, and increased expression of a β-oxidation gene (Acox1) in the liver. In particular, HY7804 showed the strongest effects both in vitro and in vivo. Therefore, HY7804, LP158, and LPC226 can be proposed as potential supplements that can improve NAFLD through anti-steatosis, anti-inflammatory, and anti-fibrotic effects.
Metagenomic Approach Deciphers the Role of Community Composition of Mycobiome Structured by Bacillus velezensis VB7 and Trichoderma koningiopsis TK in Tomato Rhizosphere to Suppress Root-Knot Nematode Infecting Tomato
Authors: Kamalanathan Vinothini , Sevugapperumal Nakkeeran , Nallusamy Saranya , Ashraf Suhail , Kailasam Kumanan , Afzal Mohd
Published: October 2023

The soil microbiome is crucial for maintaining the sustainability of the agricultural environment. Concerning the role of diverse mycobiomes and their abundance toward the suppression of root-knot nematode (RKN) infection in vegetable crops, our understanding is unclear. To unveil this issue, we examined the fungal microbiome in tomato rhizosphere augmented with bioagents challenged against RKN at taxonomic and functional levels. Composition of the mycobiome in tomato rhizosphere treated with Bacillus velezensis VB7 and Trichoderma koningiopsis TK differed significantly from the infected tomato rhizosphere. The abundance and diversity of fungal species, however, were significantly higher in the combined treatments of bioagents than for individual treatments. Fungal microbiome diversity was negatively correlated in the RKN-associated soil. Network analysis of the fungal biome indicated a larger and complex network of fungal biome diversity in bioagent-treated soil than in nematode-associated tomato rhizosphere. The diversity index represented by that challenging the RKN by drenching with consortia of B. velezensis VB7 and T. koningiopsis TK, or applying them individually, constituted the maximum abundance and richness of the mycobiome compared to the untreated control. Thus, the increased diverse nature and relative abundance of the mycobiome in tomato rhizosphere was mediated through the application of either T. koningiopsis TK or B. velezensis VB7, individually or as a consortium comprising both fungal and bacterial antagonists, which facilitated engineering the community composition of fungal bioagents. This in turn inhibited the infestation of RKN in tomato. It would be interesting to explore further the possibility of combined applications of B. velezensis VB7 and T. koningiopsis TK to manage root-knot nematodes as an integrated approach for managing plant parasitic nematodes at the field level.
Bioprospecting of Actinobacterial Diversity and Antibacterial Secondary Metabolites from the Sediments of Four Saline Lakes on the Northern Tibetan Plateau
Authors: Liu Shao-Wei , Zhai Xiao-Xu , Liu Di , Liu Yu-Yu , Sui Li-Ying , Luo Ke-Ke , Yang Qin , Li Fei-Na , Nikandrova Arina A. , Imamutdinova Arina N. , Lukianov Dmitrii A. , Osterman Ilya A. , Sergiev Petr V. , Zhang Ben-Yin , Zhang De-Jun , Xue Chun-Mei , Sun Cheng-Hang
Published: October 2023

The Tibetan Plateau, known as the “Roof of the World” and “The Third Pole”, harbors numerous saline lakes primarily distributed in the Northern Tibetan Plateau. However, the challenging conditions of high altitude, low oxygen level, and harsh climate have limited investigations into the actinobacteria from these saline lakes. This study focuses on investigating the biodiversity and bioactive secondary metabolites of cultivable actinobacteria isolated from the sediments of four saline lakes on the Northern Tibetan Plateau. A total of 255 actinobacterial strains affiliated with 21 genera in 12 families of 7 orders were recovered by using the pure culture technique and 16S rRNA gene phylogenetic analysis. To facilitate a high-throughput bioactivity evaluation, 192 isolates underwent OSMAC cultivation in a miniaturized 24-well microbioreactor system (MATRIX cultivation). The antibacterial activity of crude extracts was then evaluated in a 96-well plate antibacterial assay. Forty-six strains demonstrated antagonistic effects against at least one tested pathogen, and their underlying antibacterial mechanisms were further investigated through a dual-fluorescent reporter assay (pDualrep2). Two Streptomyces strains (378 and 549) that produce compounds triggering DNA damage were prioritized for subsequent chemical investigations. Metabolomics profiling involving HPLC-UV/vis, UPLC-QTOF-MS/MS, and molecular networking identified three types of bioactive metabolites belonging to the aromatic polyketide family, i.e., cosmomycin, kidamycin, and hedamycin. In-depth analysis of the metabolomic data unveiled some potentially novel anthracycline compounds. A genome mining study based on the whole-genome sequences of strains 378 and 549 identified gene clusters potentially responsible for cosmomycin and kidamycin biosynthesis. This work highlights the effectiveness of combining metabolomic and genomic approaches to rapidly identify bioactive chemicals within microbial extracts. The saline lakes on the Northern Tibetan Plateau present prospective sources for discovering novel actinobacteria and biologically active compounds.
Migration Mechanisms of Al3+/Li+ Lattice Impurities during Phase Transition from α-Quartz to β-Quartz: An Implication for Purification of High-Purity Quartz
Authors: Wei Zhenlun , Li Yubiao , Li Peiyue , Pan Li , Hu Xianglin , Gu Yunxiang , Tian Yan
Published: October 2023

The quality of high-purity quartz (HPQ) that used in strategic industries is normally limited due to lattice impurities. In order to reveal the migration pathway of lattice impurities in quartz particles during phase transition from α-quartz to β-quartz, α-quartz and Al3+/Li+-substituted α-quartz (S-α-quartz) was investigated under 846.15 K and 101.325 kPa based on density functional theory. Results showed that β-quartz exhibited more interstitial volume, dominating the migration of lattice impurities. This further indicates that the phase transition process was beneficial for the migration of lattice impurity from a structural point of view. Moreover, Al3+ and Li+ mainly migrated from the intracell to lattice surface along the c axis. In addition, Li+ migrated more easily than Al3+ due to higher mean square displacement values. From a thermodynamic point of view, the lower energy barrier in the case of the Al3+ and Li+ lattice suggested that the presence of lattice impurities promoted phase transition. This study therefore provides an excellent theoretical basis for the removal of lattice impurities of HPQ from an atomic perspective, for the first time.
Geochemistry and Mineralogy of the Clay-Type Ni-Laterite Deposit of San Felipe (Camagüey, Cuba)
Authors: Tauler Esperança , Galí Salvador , Villanova-de-Benavent Cristina , Chang-Rodríguez Alfonso , Núñez-Cambra Kenya , Khazaradze Giorgi , Proenza Joaquín Antonio
Published: October 2023

The Ni-laterite deposit at the San Felipe plateau, located 30 km northwest of Camagüey, in central Cuba, is the best example of a clay-type deposit in the Caribbean region. San Felipe resulted from the weathering of mantle peridotites of the Cretaceous Camagüey ophiolites. In this study, a geochemical and mineralogical characterization of two profiles (83 and 84) from the San Felipe deposit has been performed by XRF, ICP-MS, quantitative XRPD, oriented aggregate mount XRD, SEM, FE-SEM, and EMPA. Core 83, with a length of 23 m and drilled in the central part of the plateau, presents a notable concentration of cryptocrystalline quartz fragments and a rather poor content of NiO, averaging 0.87 wt.%. Core 84, which is 12 m long and drilled at the border of the plateau, lacks silica fragments and presents a higher NiO content, averaging 1.79 wt.%. The smectite structural formulae reveal that they evolve from trioctahedral to dioctahedral towards the top of the laterite profiles. Quantitative XRD analyses indicate that smectite is a dominant Ni-bearing phase, accompanied by serpentine and minor chlorite. Serpentine, as smectite, is enriched in the less soluble elements Fe3+, Al, and Ni towards the top of the profiles. Core 83 seems to have been affected by collapses and replenishments, whereas core 84 may have remained undisturbed.
Investigation into the Adsorption Mechanism of a Novel Collector Cetyl Trimethyl Ammonium Chloride on the Surface of Hematite and Quartz
Authors: Sun Haoran , Wang Yulian , Yao Jin , Yin Wanzhong , Yang Shaobin , Su Desheng
Published: October 2023

In this research, a novel collector cetyl trimethyl ammonium chloride (CTAC) was used to separate hematite from quartz via reverse flotation for the first time. Micro-flotation tests showed that CTAC had a strong ability to selectively collect quartz and that a separation of hematite from quartz could be accomplished with a concentration of 0.00263 mmol/L CTAC. Zeta-potential measurements indicated that the positive CTAC+ species could selectively increase the surface potential of quartz, but that it had rather a weak effect on the hematite. X-ray photoelectron spectroscopy (XPS) detection indicated that CTAC had a stronger binding affinity to oxygen sites on the surface of quartz than on hematite, resulting in a large amount of CTAC being predominantly adsorbed onto quartz. This was supported by the atomic concentration of C1s and N1s of quartz after CTAC treatments were 4.25 and 2.84 times higher than hematite, respectively.
Selective Recovery of Copper from the Mixed Metals Leach Liquor of E-Waste Materials by Ion-Exchange: Batch and Column Study
Authors: Ajiboye Emmanuel A. , Aishvarya V. , Petersen Jochen
Published: October 2023

Recovery of metals from e-waste forms a major focus of circular economy thinking and aligns well with the Sustainable Development Goals (SDG). While hydrometallurgical extraction from electronic printed circuit boards (PCBs) is well established, the separation of metals from the leach liquors, which are complex mixtures, remains a challenge. To achieve selective separation, ion exchange resins with chelating functional groups were employed in the present study. Batch and column studies for selective recovery of Cu2+ from a given mixed metals leach solution were conducted using Dowex M4195 resin, and both the adsorption isotherm and kinetics were studied. The process involves three major steps: selective recovery of Cu2+ by M4195 at low pH and elution with H2SO4; sorption of Ni2+ from the raffinate by Dowex M4195 at pH 2 and removal of Fe3+ from raffinate. The batch experimental results showed appreciable and selective recovery of copper (51.1%) at pH 0.7 and 40.0% Ni2+ was sorbed from raffinate at pH 2.0 with co-adsorption of Fe3+ as impurity. The batch adsorption data could be fitted with both Langmuir and Freundlich isotherms and exhibited pseudo-second-order kinetics. Column studies agreed with the Yoon–Nelson model and indicated that Cu2+ break-through time in the column decreased with an increase in flowrate from 3.0 to 10.0 min/mL and decreased in sorption capacity, while it was delayed with increased bed heights from 20 to 30 mm. Complete elution of Ni2+ was obtained with 2.0 M H2SO4 after selective elution of trace impurities with dilute HCl. Iron in the raffinate was removed via the addition of Ca (OH)2 at pH 4.0 leaving Zn-Al in the solution.
The Process Mineralogical Characterization of Bayan Obo Rare-Earth Tailings and Density Functional Theory Study of the Occurrence State of Sc
Authors: Shao Dawei , Du Xuebi , Deng Yang , Yan Zixin , Duan Wanchun , Yu Hongdong , Qi Tao
Published: October 2023

As Bayan Obo rare-earth tailings, which are generated after the production of mineral products with the raw ore from different mining areas, are considered secondary resources rich in valuable elements such as F, Fe, REE, and Nb, an effective method is urgently needed to recover such valuable elements for resource recycling and environmental conservation. A mineralogical analysis can enable process diagnosis, design, and optimization and is the key to comprehensively utilizing valuable elements. Hence, detailed mineralogical characterization is necessary as a starting point to develop a feasible processing flowsheet. In this study, various detection methods, namely inductively coupled plasma-optical emission spectrometry (ICP), X-ray Fluorescence Spectrometer (XRF), X-ray powder diffractometer (XRD), scanning electron microscopy system with an energy dispersive spectrometer (SEM-EDS), mineral liberation analysis (MLA), and electron probe microanalysis (EPMA), were applied to conduct detailed mineralogical characterization of Bayan Obo rare-earth tailings, and the occurrence state of Sc in the main Sc-bearing minerals was studied using density functional theory (DFT). The results showed that Fe mainly occurs in hematite, riebeckite, ankerite, siderite, and pyrite, with contents of 50.15 wt%, 27.94 wt%, 8.34 wt%, 4.92 wt%, and 5.59 wt%, respectively. Nearly all F occurs in 26.8 wt% fluorite. The main rare-earth minerals are bastnasite, apatite, and monazite (La), with contents of 5.0%, 5.0%, and 1.6% in Bayan Obo rare-earth tailings, respectively. Notably, 48.47%, 21.70%, 10.34%, and 10.28% of niobium element occurs in nioboaeschynite, pyrochlore, dingdaohengite, and ilmenorutile, respectively. Scandium was detected in five minerals, namely aegirine, riebeckite, monazite, ilmenorutile, and niobite, with average contents of 0.04 wt%, 0.22 wt%, 0.06 wt%, 0.06 wt%, and 1.58 wt%, respectively. According to the DFT analysis, the state of Sc in aegirine is different from that in riebeckite. Scandium in aegirine mainly substitutes Fe or enters the interstitial lattice site, while Sc in riebeckite tends to replace Fe. Based on these results, a process for recovering valuable elements from tailings is proposed.
New Insights into the Gold Mineralization in the Babaikundi–Birgaon Axis, North Singhbhum Mobile Belt, Eastern Indian Shield Using Magnetic, Very Low-Frequency Electromagnetic (VLF-EM), and Self-Potential Data
Authors: Horo Dharmita , Pal Sanjit Kumar , Singh Sahendra , Biswas Arkoprovo
Published: October 2023

The North Singhbhum Mobile Belt (NSMB) in the eastern Indian shield is an excellent example of a diverse lithological domain with multiphase shear/fracture zones. It is a well-acknowledged prospective region known for various mineralizations, e.g., Cu, Au, U, and Fe. The present study was conducted in the Babaikundi–Birgaon Axis (a shear and fracture zone within NSMB) within Babaikundi village. The study suggests that anomalous zones are possibly related to gold-associated sulfide mineralization using photomicrography and geophysical methods such as magnetic, self-potential (SP), and very low-frequency (VLF) electromagnetic (EM) methods. Photomicrography on quartz samples and Scanning Electron Microscope (SEM) Backscattered-Electron (BSE) images show that gold particles are present in the quartz reef vein in Babaikundi. Magnetic data are presented in the total magnetic intensity (TMI), upward continuation, and analytical signal maps. VLF-EM data were analyzed using different processing techniques to delineate anomalous auriferous zones. Furthermore, the SP data were inverted using the Particle Swarm Optimization (PSO), Very Fast Simulated Annealing (VFSA), and Genetic Algorithm (GA) approaches for comparative study of the resultant model parameters and their suitability considering a 2D inverted resistivity section derived using VLF-EM. The photomicrography study indicates the existence of gold/ pyrite/pyrrhotite within the Babaikundi–Birgaon axis, which corresponds to a low magnetic anomaly based on a magnetic study; a high current density, a high Fraser value, and a low resistivity based on the VLF-EM study; and a negative SP value was found based on the SP study. The combined study generally supports mapping auriferous zones and demarcates the Babaikundi–Birgaon axis within the Babaikundi–Birgaon area.
Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells
Authors: Pagani Isabel , Ottoboni Linda , Panina-Bordignon Paola , Martino Gianvito , Poli Guido , Taylor Sarah , Turnbull Jeremy E. , Yates Edwin , Vicenzi Elisa
Published: October 2023

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from death following ZIKV infection. Although heparin can be safely used during pregnancy, it retains off-target anticoagulant effects if directly employed against ZIKV infection. In this study, we investigated the effects of chemically modified heparin derivatives with reduced anticoagulant activities. These derivatives were used as experimental probes to explore the structure–activity relationships. Precursor fractions of porcine heparin, obtained during the manufacture of conventional pharmaceutical heparin with decreased anticoagulant activities, were also explored. Interestingly, these modified heparin derivatives and precursor fractions not only prevented cell death but also inhibited the ZIKV replication of infected neural progenitor cells grown as neurospheres. These effects were observed regardless of the specific sulfation position or overall charge. Furthermore, the combination of heparin with Sofosbuvir, an antiviral licensed for the treatment of hepatitis C (HCV) that also belongs to the same Flaviviridae family as ZIKV, showed a synergistic effect. This suggested that a combination therapy approach involving heparin precursors and Sofosbuvir could be a potential strategy for the prevention or treatment of ZIKV infections.
Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?
Authors: Tayal Rohit , Yasmin Sabina , Chauhan Samrat , Singh Thakur Gurjeet , Saini Monika , Shorog Eman , Althubyani Maryam M. , Alsaadi Baiaan H. , Aljohani Fatimah , Alenazi Maram A. , Abutaily Sarah A. , Ansari Mohammad Yousuf
Published: October 2023

Balancing the therapeutic advantages of a medicine with its possible risks and side effects is an important part of medical practice and drug regulation. When a drug is designed to treat a particular disease or medical condition ends up causing additional risks or side effects that lead to the development of other serious health problems, it can have detrimental consequences for patients. This article explores the correlation between persistent proton pump inhibitor (PPI) use and hypertension, a common cardiovascular ailment. While PPIs are beneficial in treating various gastrointestinal problems, their availability without a prescription has resulted in self-medication and long-term use without medical monitoring. Recent findings have revealed a link between long-term PPI usage and increased cardiovascular risks, particularly hypertension. This study investigates the intricate mechanisms underlying PPI’s effects, focusing on potential pathways contributing to hypertension, such as endothelial dysfunction, disruption of nitric oxide bioavailability, vitamin B deficiency, hypocalcemia, and hypomagnesemia. The discussion explains how long-term PPI use can disrupt normal endothelial function, vascular control, and mineral balance, eventually leading to hypertension. The article emphasizes the significance of using PPIs with caution and ongoing research to better understand the implications of these medications on cardiovascular health.
Effects of Five Coumarins and Standardized Extracts from Tagetes lucida Cav. on Motor Impairment and Neuroinflammation Induced with Cuprizone
Authors: Castro-Martínez Gabriela , Herrera-Ruiz Maribel , González-Cortázar Manases , Porras-Dávila Sandra Liliana , Almanza Pérez Julio Cesar , Jimenez-Ferrer Enrique
Published: October 2023

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with no curative treatment, and the available therapies aim to modify the course of the disease. It has been demonstrated that extracts of Tagetes lucida have immunomodulatory and neuroprotective effects. This work induced motor damage and neuroinflammation in male BALB/c mice by oral administration of cuprizone (CPZ) (40 mg/kg) for five weeks. In addition, the extracts and coumarins of Tagetes lucida (25 mg/kg) were used to control these damage variables; during the experiment, animals were subject to behavioral tests, and at the end of 5 weeks, mice from each group were used to measure the integrity of biological barriers (brain, kidneys, and spleen) through the extravasation test with blue Evans dye. In another group of animals, the ELISA method measured the brain concentrations of IL-1β, IL-4, IL-10, and TNF-α. The results presented here allow us to conclude that the extracts and coumarins IC, HN, PE, DF, and SC of Tagetes lucida exert a neuroprotective effect by controlling the motor damage and neuroinflammation by increasing the expression of IL-4 and IL-10 and decreasing IL-1β and TNF-α; notably, these treatments also protect organs from vascular permeability increase, mainly the BBB, in mice with CPZ-induced experimental encephalomyelitis (VEH * p < 0.05). However, more studies must be carried out to elucidate the molecular mechanisms of the pharmacological effects of this Mexican medicinal plant.
Biomimetic Hydrogel Applications and Challenges in Bone, Cartilage, and Nerve Repair
Authors: Gao Yanbing , Zhang Xiaobo , Zhou Haiyu
Published: October 2023

Tissue engineering and regenerative medicine is a highly sought-after field for researchers aiming to compensate and repair defective tissues. However, the design and development of suitable scaffold materials with bioactivity for application in tissue repair and regeneration has been a great challenge. In recent years, biomimetic hydrogels have shown great possibilities for use in tissue engineering, where they can tune mechanical properties and biological properties through functional chemical modifications. Also, biomimetic hydrogels provide three-dimensional (3D) network spatial structures that can imitate normal tissue microenvironments and integrate cells, scaffolds, and bioactive substances for tissue repair and regeneration. Despite the growing interest in various hydrogels for biomedical use in previous decades, there are still many aspects of biomimetic hydrogels that need to be understood for biomedical and clinical trial applications. This review systematically describes the preparation of biomimetic hydrogels and their characteristics, and it details the use of biomimetic hydrogels in bone, cartilage, and nerve tissue repair. In addition, this review outlines the application of biomimetic hydrogels in bone, cartilage, and neural tissues regarding drug delivery. In particular, the advantages and shortcomings of biomimetic hydrogels in biomaterial tissue engineering are highlighted, and future research directions are proposed.
Therapeutic Effects of Oral Application of Menthol and Extracts from Tormentil (Potentilla erecta), Raspberry Leaves (Rubus idaeus), and Loosestrife (Lythrum salicaria) during Acute Murine Campylobacteriosis
Authors: Bandick Rasmus , Busmann Lia V. , Mousavi Soraya , Shayya Nizar W. , Piwowarski Jakub P. , Granica Sebastian , Melzig Matthias F. , Bereswill Stefan , Heimesaat Markus M.
Published: October 2023

Human food-borne infections with the enteropathogen Campylobacter jejuni are becoming increasingly prevalent worldwide. Since antibiotics are usually not indicated in campylobacteriosis, alternative treatment regimens are important. We here investigated potential disease-alleviating effects of menthol and of extracts from tormentil, raspberry leaves, and loosestrife in acute murine campylobacteriosis. Therefore, C. jejuni-infected microbiota-depleted IL-10−/− mice were orally treated with the compounds alone or all in combination from day 2 until day 6 post-infection. Whereas neither treatment regimen affected gastrointestinal pathogen loads, the combination of compounds alleviated C. jejuni-induced diarrheal symptoms in diseased mice on day 6 post-infection. Furthermore, the therapeutic application of tormentil and menthol alone and the combination of the four compounds resulted in lower colonic T cell numbers in infected mice when compared to placebo counterparts. Notably, pro-inflammatory cytokines measured in mesenteric lymph nodes taken from C. jejuni-infected mice following tormentil, menthol, and combination treatment did not differ from basal concentrations. However, neither treatment regimen could dampen extra-intestinal immune responses, including systemic pro-inflammatory cytokine secretion on day 6 post-infection. In conclusion, the combination of menthol and of extracts from tormentil, raspberry leaves, and loosestrife constitutes an antibiotic-independent approach to alleviate campylobacteriosis symptoms.
Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening
Authors: Vlasiou Manos , Nicolaidou Vicky , Papaneophytou Christos
Published: October 2023

Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reversible conversion of lactate to pyruvate while reducing NAD+ to NADH (or oxidizing NADH to NAD+). Due to its central role in the Warburg effect, LDH-A isoform has been considered a promising target for treating several types of cancer. However, research on inhibitors targeting LDH-B isoform is still limited, despite the enzyme’s implication in the development of specific cancer types such as breast and lung cancer. This study aimed to identify small-molecule compounds that specifically inhibit LDH-B. Our in silico analysis identified eight commercially available compounds that may affect LDH-B activity. The best five candidates, namely tucatinib, capmatinib, moxidectin, rifampicin, and acetyldigoxin, were evaluated further in vitro. Our results revealed that two compounds, viz., tucatinib and capmatinib, currently used for treating breast and lung cancer, respectively, could also act as inhibitors of LDH-B. Both compounds inhibited LDH-B activity through an uncompetitive mechanism, as observed in in vitro experiments. Molecular dynamics studies further support these findings. Together, our results suggest that two known drugs currently being used to treat specific cancer types may have a dual effect and target more than one enzyme that facilitates the development of these types of cancers. Furthermore, the results of this study could be used as a new starting point for identifying more potent and specific LDH-B inhibitors.
The Correlation between Surface V-Shaped Defects and Local Breakdown Phenomena in GaN-Based LEDs
Authors: Baek Seung-Hye , Choi Dae-Choul , Kim Yoon Seok , Na Hyunseok , Lee Sung-Nam
Published: October 2023

This paper investigates the intriguing impact of surface V-shaped defects on the electrical and optical characteristics of GaN-based LEDs, particularly under reverse bias conditions. These defects introduce unique luminescence phenomena, notably giant dot-like luminescence (GDL), and exert significant influence on device performance. The size of these V-shaped defects plays a critical role: larger defects generate more indium-rich regions at their base, resulting in elevated tensile stress. This heightened stress promotes carrier tunneling, increasing reverse leakage current and leads to GDL formation. However, even with multiple V-shaped defects present, localized failure predominantly occurs at the defect experiencing the highest tensile stress, substantially reducing the breakdown voltage. Micro-Raman analysis further reveals distinct Raman shifts and increased tensile stress in these regions. These findings underscore the complexity of V-shaped defects’ effects, highlighting their importance in GaN-based LED design and optimization. Recognizing their influence on electrical and optical properties can significantly impact device reliability and performance, particularly in reverse bias conditions.
Spot Invalid Point Repair Algorithm of Detector Array Measurement System Based on Image Correlation Coefficient
Authors: Cheng Yilun , Wang Gangyu , Tan Fengfu , He Feng , Qin Laian , Huang Zhigang , Hou Zaihong
Published: October 2023

The detector array method has been widely used in the field of high-energy laser far-field spot parameter measurement due to its ability to directly measure the far-field spot of high-energy lasers, wide dynamic range of the detectors, high system sampling frequency, good real-time performance, and suitability for various testing environment requirements. However, during the measurement process, the irradiation of strong lasers or damage to other hardware systems can result in invalid points in the acquired spot images, thereby reducing the measurement accuracy of the system. In order to achieve accurate measurement of laser far-field spot parameters, this paper establishes an experimental model based on the analysis of the sampling spacing of the detector array target and proposes a laser far-field spot invalid point repair algorithm based on image correlation coefficient. Experimental results demonstrate that the algorithm proposed in this paper effectively reduces the impact of invalid points in the measurement system on the measurement accuracy, and achieves accurate measurement of high-energy laser measurement systems.
ZnO-Based Materials: From Pauli’s Nonsense to a Key Enabling Technology
Authors: Ramos-Justicia Juan Francisco , Ferreiro Adalyz , Flores-Carrasco Gregorio , Rodríguez-Cañamero Sara , Urbieta Ana , Rabanal María Eugenia , Fernández Paloma
Published: October 2023

In this work, we aim to highlight the increasing interest in semiconductors, particularly ZnO. A revision of the evolution of the scientific production on three selected topics has been conducted. As an indicator of scientific production, the number of publications indexed in the Web of Science Data Base has been used. The search terms selected range from the general to the particular: semiconductors, oxide semiconductors, and ZnO. The period considered is from 1 January 1900 to 6 June 2023. The importance of doping processes in tailoring the properties of these materials, and the relevance of the most recently derived applications are also revised. Since many of the most recent applications that have been developed or are under development refer to optoelecronic properties, doping with rare earth elements has a central role. This was the reason behind choosing the system ZnO doped with Rare Earth elements (Eu, Gd, and Ce) and codoped with Ru to illustrate the materials’ tuning potential of doping processes. Morphology, crystal structure, and luminescent properties have been investigated. Upon doping, both the Near Band Edge and the Deep Level emissions show a remarkable difference due to the change in the relative weight of the components constituting these bands. The spectra in all cases extend over the whole visible range, with a main emission in the violet-blue region corresponding to the Near Band Edge, and a broad band extending from the blue-green to orange-red region associated with the presence of different defects.
Optical Design of an LCoS-Based 1 × 10 WSS with High Coupling Efficiency and Compact Light Paths
Authors: Ji Huiru , Shan Yuefan , Mo Yan , Chen Zhihao , Ma Donglin
Published: October 2023

In the field of communication, the utilization of Liquid Crystal On Silicon (LCoS) in Wavelength Selective Switch (WSS) systems holds great promise. However, the lack of research on the optical path design of LCoS-based WSS makes it challenging to realize high-port-count and perfect performance with a compact structure. In this paper, the conceptual optical path design method of a compact LCoS-based 1 × 10 WSS system working in C-band (1529 nm–1568 nm) is proposed, where there exists 1 input port and 10 output ports in the same array. The optical powers in both the wavelength and deflection directions have been meticulously considered separately, while the polarization-independent structure has been designed novelty, which boost system compactness and lowers manufacturing costs. Finally, a high fiber-to-fiber coupling efficiency of an idealized system ranging from 95.07 to 99.18% with only five components is achieved. Furthermore, a brief tolerance analysis to demonstrate the instrumentation feasibility is also conducted and the additional losses that will be introduced by real experiments are discussed. Our work is pioneering in providing a more straightforward methodology and conceptual model for WSS system design and offering reference significant for high-port-count systems.