bluuebunny/crossref_metadata_2025 huggingface dataset:
Here I Go: Three sections from ‘Here I Go’, 1999–2002
Authors: Smith Dale
Published: December 2023

[para. 1]: "“Now as then I lose myself in words above my head,” Robert Duncan wrote in Ground Work II, “in following words naked of meaning, as I was in the beginning, hearing the magic voice beyond my sight, out of sight, puts on and removes faces not meant for me” (20). In summer 1999 I began reading of Egyptian fetish and myth. Stories of Isis, Osiris and hermetic Thoth cohered for me, and their themes merged through other reading, as I submerged under a current of old religion. Even in Harry Smith’s Anthology of American Folk Music I heard trace themes of that past. Robert Duncan seemed an embodiment of this magic. His incantations took the spoken form of the seeker, revealing with instantaneous reaches forward the voices in him. “They are mouthing each other in the passages between words and I hear the sound of sucking, the holding of breath and the releasing of breath in vowels I will yet come to from — the labials, the nasals, the fricatives. I will yet come to. Behind the mouth an intent to speak to me returns again and again to the same patterns and urgencies. The same hooves the tread of feet moving through sentences in phrases, the verges of time, of march and mazurka. It is 1921, remember. Someone has let loose the tango. The seed of the mind to be is in a lull a bye bye that comes round to say good bye again.”"

 
Dale Smith reviews Evidence of the Paranormal [Book review]
Authors: Smith Dale
Published: December 2023

[para. 1]: "This is a delightful presentation of investigations in poetry and visual art of paranormal existence. This combination of visual and written art creates a fissure in reality’s so-called seam. Carl Jung declared somewhere that he was an empiricist of invisible phenomena, a good tag for someone sensitive to the inner nature of forms. The poets here, in collision or collusion with Yackulic’s drawings, gather images and insights of such phenomena.

 
Edward Dorn Out: Forms of Dispossession
Authors: Smith Dale
Published: December 2023

[para. 1]: "In the summer of 1965 Edward Dorn attended the Berkeley Poetry Conference, substituting for LeRoi Jones. He spoke to the audience of his travel with photographer Leroy Lucas through what is known geographically as the Basin-Plateau, an area occupied by several of the western United States, including Idaho, Oregon, Nevada, and Utah. Beginning in Duck Valley, on the Nevada-Idaho border and continuing west as far as Reno, both men documented their experiences on long and often gravelly roads that led from boom-and-gloom towns of western settlement to more desolate and isolate reservations. The results of their journey were documented and published a year later

in The Shoshoneans: The People of the Basin-Plateau."
Women Write Iran: Nostalgia and Human Rights from the Diaspora
Authors: Naghibi Nima
Published: December 2023

Women Write Iran is the first full-length study on life narratives by Iranian women in the diaspora. Nima Naghibi investigates auto/biographical narratives across genres—including memoirs, documentary films, prison testimonials, and graphic novels—and finds that they are tied together by the experience of the 1979 Iranian revolution.
Marjane Satrapi’s Persepolis
Authors: Naghibi Nima , O'Malley Andrew
Published: December 2023

[Para. 1]: "When Marjane Satrapi's auto|biographical comic Persepolis: The Story of a Childhood was published in English by Random House in 2003, it became an instant bestseller. As we mentioned in our 2005 article, when the book was first published in English translation and entered the North American literary market, it seemed that bookstores were uncertain what to do with it, shelving it in any number of sections - for example, autobiography or life writing, graphic novels, Middle Eastern history, young adult, or children's literature."
Queer Collectivity in the Echoes of the Dance Floor
Authors: Jennex Craig
Published: December 2023

[pp. 7-8]: "Queer dance floor experiences of the past can continue to offer possibility in the present. Indeed, when we embrace music’s ability to elicit collective experiences of lingering, we bind ourselves to historical echoes and the individuals moved by them in the first place. One thing that makes these experiences of dance floor bliss so profound is that they are simultaneously individual and collectivizing—they feel so personal yet they necessarily tether us to others. Perhaps contemporary queerness is less about an identity claim or a series of acts in the present—maybe it’s about how we linger in and with the queer past. Perhaps it is this history and our ongoing orientation to it that allows us access to the radical potential of queerness today."
Implementing Group Exercise Techniques to Foster Gratitude in Adolescents
Authors: Marsela Fitra , Amirullah M
Published: December 2023

This research is predicated on the significance of gratitude as a positive emotion that adolescents need to cultivate in order to build resilience and readiness to face challenges. The objective of this study is to explore the potential of group exercise techniques in fostering gratitude among adolescents. Adolescents are expected to exhibit various positive traits, such as competitiveness, intelligence, self-regulation, self-disclosure, and a heightened sense of gratitude. The data analysis in this study employed the Miles and Huberman model, which consists of three stages: 1) reduction, 2) presentation, and 3) verification. The findings suggest that gratitude is a crucial characteristic in adolescents, and group exercise techniques can potentially enhance this trait. By nurturing gratitude in adolescents, they can achieve psychological well-being and mitigate negative emotions such as anxiety, anger, and sadness
Management Guidance and Counseling in Senior High Schools in the Face of Globalization Era
Authors: Juwita Ulandari , Firman Firman , Suhaili Neviyarni , Che Amat Muhammad Asyraf Bin
Published: December 2023

Globalization has permeated all facets of life, including education. Education transcends national borders, facilitated by technological advancements and various methodologies. The era of globalization has both positive and negative impacts on students. Consequently, counselors must guide students towards global progress while preserving existing cultural values. The execution of guidance and counseling management must be technology-based and globally oriented. This has implications for the programs developed and the collaboration with all personnel implementing guidance and counseling in senior high schools. To conduct guidance and counseling management in line with the developments in the globalization era, the quality of human resources, or the competence of counselors, needs to be enhanced to be sensitive to opportunities and responsive to global challenges. The method employed is descriptive with a naturalistic qualitative approach, which reveals real events in natural conditions (natural settings). The instrument in this naturalistic qualitative research is the researcher himself, through self-evaluation regarding his understanding of qualitative methods, mastery of theory, insight into the field being researched, and readiness and provisions for fieldwork. The subjects in this research were five guidance and counseling teachers, the principal, and three students at State Senior High School 4 Sungai Penuh. The results of this research provide an overview of counseling management in schools and the competencies that counselors need to master to navigate the era of globalization
Work-Family Conflict among Women: An Islamic Perspective
Authors: Narti Zulhelmi , Afdal Afdal , Hariko Rezki
Published: December 2023

Work-family conflict is a form of role conflict that arises within an individual due to conflicting pressures from work and family roles. This research focuses on work-family conflict as experienced by women. The aim of this study is to understand how work-family conflict is experienced by female educators. This study employs a descriptive quantitative research method, utilizing a work-family conflict scale. The sampling technique used was a saturated sample, comprising 21 female educators. The results indicate that the work-family conflict experienced by female educators falls into the high category. This suggests that they have not yet mastered the management or regulation of their roles, both within the family and at work.
The Impact of Islamic Financing Products on Islamic Banks Profitability: Case of Al Rayan Bank (Qatar)
Authors: Moustapha Larabi , Nadir Troubia
Published: December 2023

This study aims to determine the effect of islamic financing products   on Islamic banks profitability of Al Rayan Islamic Bank. This research uses Quarterly data of Al Rayan Bank for 2011Q1-2023Q1.The variables used in this study are independent variables, Musharaka, Murabaha, Istisna’a and Ijarah financing. While the dependent variable is, the Islamic bank's profitability measured by (ROE).The study used ARDL Model to analyze the short and long-term relationships between variables. Data collected were analyzed by using EViews10 software. ARDL bounds test findings shown that there is a cointegration relationship between bank profitability and Islamic financing Products variables in the long run. The results of the long-run analysis show that Musharaka financing has a positive and significant effect on ROE at the 5% level. Murabaha financing has a negative and significant effect on ROE. Meanwhile, the Istisna’a and Ijarah variables have no significant effect on ROE. The short run dynamics show that there is a negative and significant effect of Murabaha and Ijarah financing on the profitability of the Islamic bank, while lagged value of Murabaha LMUR(-1) has a positive and significant effect on the profitability index of the Islamic bank. Simultaneously, there is no relationship and effect of Musharaka and Istisna’a on the profitability of the Islamic bank in the short term
ПОРІВНЯЛЬНИЙ АНАЛІЗ ВІТЧИЗНЯНОГО ТА ЄВРОПЕЙСЬКОГО ЗАКОНОДАВСТВА З ПИТАНЬ ЗАПОБІГАННЯ КІБЕРЗЛОЧИННОСТІ
Authors: Лугіна Н. А. , Лучук А. М.
Published: December 2023

У статті розглянуто проблемні аспекти, що виникають під час запобігання кіберзлочинності в Україні. Проаналізовано різні визначення поняття кіберзлочинів, серед яких наведено законодавче визначення поняття «кіберзлочин». Наведено класифікацію кіберзлочинів, надану Будапештською Конвенцією про кіберзлочинність. Зосереджено увагу на національній законодавчій базі, що регулює питання боротьби з кіберзлочинністю та міжнародних нормативно-правових актах з цього питання. Акцентовано увагу на міжнародно-правовому співробітництві в роботі щодо попередження та протидії транскордонним та транснаціональним кіберзлочинам. Встановлено загальні та спеціальні причини неефективності запобіжної діяльності у сфері кіберзлочинності в Україні. Запропоновано шляхи подолання виявлених проблем.

Сьогодні важко сперечатися щодо питання важливості мережі «Інтернет» у нашому житті. Інтернет відкриває перспективи для саморозвитку, отримання нових знань, пошуку роботи тощо. Цей ресурс використовуємо щодня, навіть свій вільний час можемо проводити на його просторах. Але пропри це інтернет має й іншу сторону, ту, в якій щодня, щогодини вчиняються кримінальні правопорушення, адже платформа забезпечує користувачів повною анонімністю та не обмежує їх у своїх діях.

Наприклад, 2018 року в Україні працівники Департаменту кіберполіції Національної поліції України були залучені до більше ніж одинадцяти тисяч кримінальних проваджень, пов’язаних з кримінальними правопорушеннями у сфері новітніх інформаційних технологій. Протягом року було встановлено, що найбільша кількість протиправних діячів перебуває в Києві, а також на території Одеської, Миколаївської та Львівської областей.

Хоч і всі науковці достатньо ґрунтовно розкривають проблему у своїх дослідженнях, необхідно все ж таки узагальнити накопиченні знання, зануритися у саму історію виникнення та розвитку кіберзлочинності для можливості аналізу дій злочинців відносно розвитку технологій.

Проаналізувавши наукові дослідження та досвід різних країн у боротьбі з таким явищем, можна стверджувати, що ця проблема є чи не найнебезпечнішою у ХХІ столітті і є нагальна потреба вдосконалення законодавства та проведення роз’яснювальних дій у суспільстві задля подальшого запобігання створенню нових груп кіберзлочинців та розповсюдженню такого явища.
СИСТЕМА КРИМІНАЛЬНИХ ПРАВОПОРУШЕНЬ У СФЕРІ ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ: МІЖНАРОДНО-ПРАВОВИЙ ВИМІР
Authors: Топчій В. В. , Бодунова О. М.
Published: December 2023

У статті досліджується система кримінальних правопорушень у сфері інформаційних технологій відповідно до норм міжнародного права. Зазначено, що впродовж останнього двадцятиліття у світі триває процес формування інформаційного суспільства, а тому все більше розвиваються обчислювальні та інформаційні мережі — унікальне поєднання комп’ютерів і комунікацій. З кожним днем більш активно розвиваються сучасні інформаційні технології і в Україні. Людська цивілізація на межі тисячоліть вступила в еру інформації. Світовою системою комп’ютерних комунікацій щодня користуються сотні мільйонів людей. Це надає нові можливості розвитку національної культури, освіти, науки й економіки.

Проте технологічний прогрес і впровадження інформаційних технологій у всі сфери життєдіяльності суспільства має негативний ефект, оскільки це призводить до збільшення кількості кримінальних правопорушень. Також це дає змогу вчиняти кримінальні правопорушення новими, нетрадиційними способами.

Особливо в умовах ведення повномасштабної війни росії проти України використання інформаційних технологій під час вчинення кримінальних правопорушень є звичним явищем для окупантів, що зумовлює розширення переліку кримінально протиправних діянь, які вчиняються у сфері інформаційних технологій.

© Бодунова О. М., Яцик Т. П., 2023

 

© Бодунова О. М., Яцик Т. П., 2023

 

Зроблено висновок, що з розвитком технічного прогресу видозмінюється і злочинність, яка набуває нових, раніше невідомих форм. Так, з виникненням у середині XX століття електронно-обчислювальних пристроїв поняття злочинності в цій сфері неодмінно пов’язувалося з предметом кримінально протиправного впливу або предметом кримінального правопорушення, яким є комп’ютер. Об’єднання комп’ютерів у мережі (локальні, глобальні) надало можливість використовувати ЕОМ як засіб кримінального правопорушення, а місцем його вчинення став кіберпростір.

Зважаючи на викладене, у міжнародних нормативно-правових актах універсальне коло кримінальних правопорушень у сфері інформаційних відносин досі не визначене. Це пов’язано з динамічним розвитком злочинності, виникненням нових видів кримінальних правопорушень, що вчиняються у сфері інформаційних технологій. Тому на сьогодні актуальним питанням залишається розроблення єдиної кримінальної стратегії, пов’язаної з комп’ютерними кримінальними правопорушеннями, їх поняттям та системою.
ПРОТИДІЯ ІНФОРМАЦІЙНІЙ СКЛАДОВІЙ ГІБРИДНОЇ ВІЙНИ
Authors: Дирдін М. Є. , Яцик Т. П.
Published: December 2023

У статті проаналізовано проблему інформаційної безпеки України та вплив гібридної війни на національну безпеку держави в цілому та інформаційний простір безпосередньо. Розглянуто відмінності гібридної війни від звичайної та виділено характерні її ознаки. Окреслено рівні війни, на яких можливо прослідкувати гібридну війну. Проаналізовано причини, що створюють сприятливе середовище для розвитку гібридних воєн. Розглянуто наявні та потенційно можливі явища і чинники, які створюють небезпеку життєво важливим інтересам людини та громадянина, суспільства і держави в інформаційній сфері. На основі позитивного міжнародного досвіду запропоновано заходи протидії інформаційній складовій гібридної війни.
ОКРЕМІ АСПЕКТИ РОЗВИТКУ НОВИХ МЕТОДИК У КРИМІНАЛІСТИЦІ
Authors: Дідківська Г. В. , Педан В. І.
Published: December 2023

У цій статті зазначено, що з огляду на те, що криміналістика є окремою галуззю знань, а її власні методи щодо загальної класифікації методів пізнання можуть визначатися як окремонаукові. Водночас звертається увага, що у класифікації методів криміналістики їх бажано визначати як спеціальні, підкреслюючи тим самим своєрідність цих пізнавальних засобів щодо сфери криміналістичних досліджень. Серед загальнонаукових методів, які, безумовно, пронизують усі напрями криміналістичних досліджень, особливо виокремлені ті, що становлять основу для формування нових сучасних пізнавальних підходів. Ідеться передусім про формалізацію, системний, структурно-функціональний та імовірно-статистичний методи.

Акцентується увага на тому, що криміналістичні методи створені та обґрунтовані теорією криміналістики або запозичені та перетворені нею спеціально для дослідження криміналістичних об’єктів. До них належать різноманітні судово-фотографічні, трасологічні, судово-балістичні та інші методи. Наприклад, у галузі судової фотографії розроблені методи сигналетичної (впізнавальної), вимірювальної, панорамної, стереоскопічної, мікроскопічної, крупномасштабної та інших видів фотозйомки, методи фотографічного підсилювання кольорових контрастів, методи виявлення текстів, що неможливо прочитати, тощо.
PERANCANGAN PROTOTYPE KONTROL DAN MONITOR LEVEL AIR PADA MESIN BOILER BERBASIS IoT (Internet of Things)
Authors: Prasetyo Heru , Wijaya Toni Kusuma , Algusri Missyamsu
Published: December 2023

ABSTRAK

Abstract - Sensor ultrasonic untuk mengukur ketinggian ini memanfaatkan dari karakteristik yang dimiliki oleh sensor tersebut, sensor ini akan mengirim sinyal jika sensor ini menabrak benda apapun yang bukan dari udara, kekurangan dari sensor ini untuk sensor air adalah jika ada benda asing yang menutupi sensor sehingga level air tidak sesuai dengan lapangan. Banyak media yang digunakan sistem kontroler dalam mengirim data contohnya seperti serial komunikasi RS-485 dan RS-232 untuk mengirim dengan kabel, ada juga media pengiriman berupa Bluetooth, frekuensi radio, dan Wifi. Kali ini kita akan menggunakan media Wifi untuk mengirim data yang telah diambil dari sensor ultrasonic, pressure sensor, dan flow sensor.

Kata kunci: Blynk, ESP 8266 Node MCU, IoT (Internet Of Things) Serial komunikasi Wifi

Abstrak - This ultrasonic sensor for measuring the level takes advantage of the characteristics possessed by the sensor, this sensor will send a signal if this sen sor hits any object that is not from air, the drawback of this sensor for the water sensor is if there is a foreign object covering the sensor so that the water level does not match the field. There are many media used by the controller system in sending data, for example, such as serial communication RS-485 and RS-232 to send by cable, there are also transmission media in the form of Bluetooth, radio frequency, and Wifi. This time we will use Wifi media to send data that has been taken from a ultrasonic sensor, pressure sensor, flow sensor.

Keywords: Blynk, ESP 8266 Node MCU, IoT (Internet Of Things) Wifi Communication Serial
PENGARUH PERLAKUAN PANAS TERHADAP PROSES PERMESINAN BAJA KARBON RENDAH
Authors: Hakim Arif Rahman , Nurlaila Qomaratun , Lase Zulfikri
Published: December 2023

Permesinan dilakukan untuk membentuk benda kerja sesuai dengan desain. Pengerjaan permesinan meliputi boring, drilling, pembubutan, dan frais. Permesinan juga dilakukan untuk memperbaiki bagian elemen mesin yang menglami kerusakan atau keausan. Sebelum dilakukan permesinan terkadang material mengalami perlakukan panas. Dalam studi ini akan dipelajari bagaimana pengaruh perlakuan panas quenching pada baja karbon rendah dengan suhu yang bervariasi. Perlakuan panas dilakukan dengan memanaskan benda uji dengan variasi suhu (3000C, 3500C, 4500C, 550 0C, dan 750 0 C), dengan waktu tahan 5 menit kemudian didinginkan secara lambat dan pendinginan cepat serta menggunakan udara dan air tawar. Studi ini memperlihatkan bahwa Perlakuan panas pada baja karbon rendah mempengaruhi laju permesinan (drilling). Perbandingan laju permesinan drilling terhadap variasi suhu perlakuan panas baja karbon rendah memperlihatkan perubahan laju yang signifikan. Benda uji (TP A, suhu perlakuan panas 300oC) tanpa quenching mempunyai laju drilling rata-rata 9,1 mm/menit. Benda uji (TP B, suhu perlakuan panas 350oC) mempunyai laju drilling rata-rata 7,5 mm/menit. Benda uji (TP C, suhu perlakuan panas 450oC) mempunyai laju drilling rata-rata 6,56 mm/menit. Benda uji (TP D, suhu perlakuan panas 550oC) mempunyai laju drilling rata-rata 5,97 mm/menit dan Benda uji (TP E, suhu perlakuan panas 750oC) mempunyai laju drilling rata-rata 1,2 mm/menit
EVALUASI DEFECT PRODUK SARUNG ATBM BERBASIS PENDEKATAN GREY FMEA DAN RCA
Authors: Olivia Vina Agustin , Mahbubah Nina Aini
Published: December 2023

Product quality is a crucial factor in maintaining business continuity by implementing essential processes. The traditional production process of a sarong involves non-machined looms (ATBM), which can lead to defects that reduce the quality of the sarongs. This research aims to evaluate the occurrence of defects throughout the ATBM sarong production process using the Grey-FMEA and RCA approaches. The results of the Grey FMEA method showed that defects occurred in woven sarongs due to the sheath-cutting error and color mixing score during the thread dyeing process. The factor causing the defect is the error in cutting long and short woven sarongs differently due to a mismatch in the pattern of the woven sarong. Therefore, the proposed improvement is that artisans should concentrate on making woven sarongs. Analysis of the causes of sheath defects in the color mixing process during the yarn dyeing process found that poor quality paint and yarn affected the process of dye absorption into the yarn. The proposed improvement includes quality dye and thread raw materials that should be provided so that quality products will be produced.
EVALUASI PEMBOROSAN MESIN JUMBO LOOM BERBASIS PENDEKATAN STATISTICAL PROCESS CONTROL
Authors: Nofanda Taraz Atillah , Mahbubah Nina Aini
Published: December 2023

Continuous quality control along the production line is a crucial factor in achieving high productivity. PT. TRZ is a producer of various types of plastic-based products that implement strict quality control standards. However, it is still found that production targets still need to be achieved due to machine damage. This machine breaks. The company needs to be able to fulfill consumer orders on time. This research aims to evaluate product defects resulting from damage to the Jumbo Loom machine. Statistical process control evaluates factors in cutting machine defects, thread splice marks, and sheet shrinkage. The research results show that the company faces problems regarding machine defects, including machine running, thread splice marks, and shriveled sheets. This research aims to reduce defects in machines. The Seven Tools method is used to make repairs. From the processing results on the control chart, there were daily defects that exceeded the control limits. Therefore, it was carried out using a fishbone diagram. The processing results obtained 23 indicators of the causes of the three types of defects.
PERANCANGAN PROTOTYPE PENGAKSES PALANG PINTU MENGGUNAKAN SISTEM RFID RC522 BERBASIS ARDUINO UNO
Authors: Viantika Anton , Yuswardi Aan
Published: December 2023

Palang Pintu adalah suatu alat pembatas akses baik orang maupun kendaraan dari keluar ataupun masuk dari area tertentu. Secara umum palang pintu terbagi menjadi dua, yaitu palang pintu manual dan palang pintu otomatis. Penelitian ini berfokus pada penelitian mengenai perancangan pengakses palang pintu dengan menggunakan kartu akses yang berbasis RFID (Radio Frequency identification) untuk mengontrol pergerakan palang pintu dengan sebuah sistem yang didalamnya terdapat RFID, mikrokontroler, dan aktuator. Penelitian ini menggunakan RFID RC522 sebagai pendeteksi kartu akses. Dari perancangan prototype yang telah dibuat didapat adalah jarak tapping kartu RFID ke RFID reader maksimal sejauh 4cm dan bila lebih dari jarak tersebut, kartu akses tidak dapat terdeteksi. Palang pintu akan terbuka ataupun tertutup tergantung besar sudut motor servo dipengaruhi oleh seberapa besar pulsa yang diberikan.
Rapid Enlightenment Process
Authors: King Juan Pablo Alfredo Sanchez
Published: December 2023

This article describes the Rapid Enlightenment Process (REP). An intervention focused on entrepreneurs and business executives to increase their psychological resources. The treatment has four components: (1) Understanding of the survival mind; 2) Acceptance; (3) Recontextualization; and 4) Adoption of the “Enlightened Perspectives,” helpful hermeneutics and heuristics to sustain the experience of peace and positive emotions until it becomes a habit. The paper builds on arguments and ideas presented in a theoretical model with the primary objective of formulating a set of propositions detailing factors affecting the REP and the effectiveness at each of its phases. Since REP is an innovation lacking empirical evidence, its claims are supported by a logic model referencing theories and research in the field of positive psychology, neuroscience, and an integrated framework of emotional theories. This paper aims to contribute to the well-being intervention literature to guide empirical research, and ultimately to evaluate REP.
A desidratação como estratégia para rápida perda de peso em praticantes de luta
Authors: Santos Bárbara Freitas , Mendes João Pedro , Cruz Michele Ferro de Amorim
Published: December 2023

O M.M.A (Mixed Martial Arts) é um esporte de combate que engloba os mais variados tipos de luta, na qual os competidores são divididos por categorias de acordo com seu peso. Sendo assim, muitos lutadores buscam estratégias, como a desidratação, para se adequarem a categorias inferiores. O objetivo do trabalho é avaliar as condutas utilizadas para a desidratação e os impactos dessa prática no desempenho esportivo do atleta no período pré e pós competitivo. O estudo se trata de uma revisão bibliográfica com artigos relacionados ao tema, com intuito de esclarecer os efeitos prejudiciais à saúde na rápida perda de peso sem um acompanhamento nutricional adequado. A análise dos resultados mostrou que alguns atletas apresentaram cãibras, fortes dores de cabeça, diminuição do desempenho e alterações hormonais significativas como consequência da prática, diante dos resultados é notável a necessidade de mais estudos aprofundados sobre o tema e suas principais consequências.
Rethinking the Holocene temperature conundrum
Authors: Essell H , Esper J , Wanner H , Büntgen U
Published: December 2023

Recent scholarship argues for more research to resolve the ‘Holocene temperature conundrum’, an apparent discrepancy between decreasing proxy-reconstructed and increasing model-simulated long-term temperature trends during the late Holocene. Here, we argue that the observed proxy-model offset likely results from inappropriate comparisons of different seasonal and spatial signals in the reconstructed and simulated palaeo-data. Since proxy archives have been used to reconstruct global annual mean temperatures, they have been compared against model simulations of the same seasonal and spatial domains. However, we suggest that most of the proxy-based large-scale reconstructions are biased towards Northern Hemisphere summer temperatures, and as such model comparisons have predominantly focused on the wrong target data. Further to advancing our understanding of long-term temperature trends, we recommend prioritising the refinement of proxy networks and climate reconstructions to preserve the full spectrum of naturally forced, interannual to multi-millennial variations needed to contextualise recent anthropogenic changes against past Holocene ranges.
Inhibition of Beta-1 Receptor but not Vagotomy Can Abolish the L-NAME Evoked Bradycardia in Anesthetized Rat.
Authors: Vág J , Hably C , Bartha J
Published: December 2023

We reported previously that the nitric oxide synthesis inhibitor Nv-nitro-L-arginine methyl ester (L-NAME) decreases cardiac output. Several studies have shown that inhibition of nitric oxide synthesis decreases the heart rate. In the present study, we investigated the effect of a single bolus administration of L-NAME on blood pressure and heart rate monitored for one hour in anesthetized rats and the influence of vagotomy and b1-receptor blocker metoprolol on the
L-NAME induced bradycardia. After L-NAME treatment, the blood pressure rose immediately after the injection of the drug (peak response in the third minute: +24 %, p<0.001) and fell to the control level in the 20th minute. The heart rate decreased immediately after L-NAME administration, the lowest value being reached in the 10th minute (-14 %, p<0.001). However, bradycardia was sustained even after the blood pressure had returned to the control level. Bilateral vagotomy failed to influence the negative chronotropic effect of L-NAME, but bradycardia was completely abolished by metoprolol pretreatment. We concluded that the bradycardia evoked by L-NAME is mainly due to the withdrawal of sympathetic tone upon the heart rate. However, the cause of sustained bradycardia after normalization of blood pressure cannot be elucidated.
A Web-based Point of Sales for Automotive Component Industry using Rapid Application Development model
Authors: Melvin Melvin , Wiratama Jansen , Sutomo Rudi , Sanjaya Samuel Ady
Published: December 2023

This research aims to increase efficiency in Micro, Small, and Medium Enterprises (MSMEs) in the automotive components industry, focusing on CV Bengkel Megamakmur. This workshop is one of the MSMEs engaged in Indonesia's car spare parts industry. In the ongoing business process, these MSMEs need some help in inventory management, stock of goods, and less integrated sales transaction recording. The main problem identified was the discrepancy between the number of products sold and sales transaction reports. A web-based Point of Sale (POS) application was implemented, which allows the integration of inventory data and sales transactions. The method used in this research is Rapid Application Development (RAD), suitable for projects with limited resources and short work schedules. This research results in a Point of Sale application that can optimize business processes for managing inventory by monitoring stock and recording sales transactions in an integrated manner. This application has been tested using the System Usability Scale (SUS) method and obtained an average score of 86.6, included in the "very good" category. The test results show that this application has good functionality and can optimize MSME business processes in the automotive components industry.
Pengembangan Sistem Informasi Pendaftaran Pasien Klinik Praktik Bersama di Kabupaten Ponorogo Menggunakan Framework Codeigniter
Authors: Hafidhoh Nisa'ul , Lestariningsih Tri , Arisanto Ervany Septa Prawara
Published: December 2023

Klinik adalah tempat pelayanan kesehatan yang diberikan kepada masyarakat umum. Kabupaten Ponorogo memiliki berbagai klinik praktik bersama yang membantu masalah kesehatan masyarakat yang tersebar di berbagai wilayah Kabupaten Ponorogo. Sebagian pemberian layanan pendaftaran pada klinik yang berada di Kabupaten Ponorogo saat ini masih manual, yaitu pendaftaran pasien dengan cara mendatangi klinik secara langsung atau mendaftar melalui telepon. Selain itu, masyarakat juga mengalami kesulitan menentukan klinik terdekat sehingga dapat menghambat layanan kesehatan untuk pasien. Oleh karena itu, dibutuhkan sistem informasi terkait klinik praktik bersama yang dapat membantu mendaftarkan pasien, sehingga tidak perlu menunggu lama untuk mengantri. Pengembangan sistem informasi pendaftaran pasien klinik praktik bersama di Kabupaten Ponorogo berbasis web ini menggunakan model prototyping dan memanfaatkan framework CodeIgniter. Pengujian dengan metode blackbox testing digunakan untuk menguji sistem dan hasilnya menunjukkan bahwa sistem telah berfungsi dengan baik. Dengan adanya sistem ini dapat membantu pengguna melihat lokasi klinik praktik bersama di sekitarnya dan melakukan pendaftaran pasien pada klinik tertentu.
Codon optimization regulates IgG3 and IgM expression and glycosylation in N. benthamiana
Authors: Sun Lin , Kallolimath Somanath , Palt Roman , Eminger Florian , Strasser Richard , Steinkellner Herta
Published: December 2023

Plants are being increasingly recognized for the production of complex human proteins, including monoclonal antibodies (mAbs). Various methods have been applied to boost recombinant expression, with DNA codon usage being an important approach. Here, we transiently expressed three complex human mAbs in Nicotiana benthamiana, namely one IgG3 and two IgM directed against SARS-CoV-2 as codon optimized(CO) and non-codon optimized (NCO) variants. qRT-PCR exhibited significantly increased mRNA levels of all CO variants compared to the non-codon optimized orthologues, in line with increased protein expression. Purified CO and NCO mAbs did not exhibit obvious biochemical differences, as determined by SDS-PAGE and antigen binding activities. By contrast, enhanced production selectively impacts on glycosite occupancy and N-glycan processing, with increased mannosidic structures. The results point to a careful monitoring of recombinant proteins upon enhancing expression. Especially if it comes to therapeutic application even subtle modifications might alter product efficacy or increase immunogenicity.
Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents
Authors: Yang Yaochen , Yang Yuanyuan , Hou Zhipeng , Wang Tingting , Wu Peng , Shen Lufan , Li Peng , Zhang Kai , Yang Liqun , Sun Siyu
Published: December 2023

Esophageal stricture (ES) results from benign and malignant conditions, such as uncontrolled gastroesophageal reflux disease (GERD) and esophageal neoplasms. Upper gastrointestinal endoscopy is the preferred diagnostic approach for ES and its underlying causes. Stent insertion using an endoscope is a prevalent method for alleviating or treating ES. Nevertheless, the widely used self-expandable metal stents (SEMS) and self-expandable plastic stents (SEPS) can result in complications such as migration and restenosis. Furthermore, they necessitate secondary extraction in cases of benign esophageal stricture (BES), rendering them unsatisfactory for clinical requirements. Over the past 3 decades, significant attention has been devoted to biodegradable materials, including synthetic polyester polymers and magnesium-based alloys, owing to their exceptional biocompatibility and biodegradability while addressing the challenges associated with recurring procedures after BES resolves. Novel esophageal stents have been developed and are undergoing experimental and clinical trials. Drug-eluting stents (DES) with drug-loading and drug-releasing capabilities are currently a research focal point, offering more efficient and precise ES treatments. Functional innovations have been investigated to optimize stent performance, including unidirectional drug-release and anti-migration features. Emerging manufacturing technologies such as three-dimensional (3D) printing and new biodegradable materials such as hydrogels have also contributed to the innovation of esophageal stents. The ultimate objective of the research and development of these materials is their clinical application in the treatment of ES and other benign conditions and the palliative treatment of malignant esophageal stricture (MES). This review aimed to offer a comprehensive overview of current biodegradable esophageal stent materials and their applications, highlight current research limitations and innovations, and offer insights into future development priorities and directions.
Recovery of uranium from phosphate ore in the Sheikh Habil-Iran mine: part I— multivariable optimization of leaching process using the response surface method
Authors: Abdeshahi A. , Outokesh M. , Nejad D. Ghoddocy , Zare M. Habibi , Sadeghi M. H.
Published: December 2023

In this research, the recovery of uranium from the phosphate ore of the Sheikh Habil-Iran mine using flotation/calcination-leaching processes has been investigated. A 75–150 μm phosphate ore particle size, sodium oleate as a collector with a concentration of 2,000 g/ton of rock, pH = 10, and 5 min flotation time were obtained as the optimum parameters of flotation using the reverse method, leading to phosphate ore with a grade of 180 ppm UO2, 36.1% P₂O₅, 7.22% SiO2, and CaO/P₂O₅ = 1.23. The optimum calcination parameters were selected as 100 μm phosphate ore particles size at D80, 900°C temperature, and 2 h heating time, which resulted in phosphate ore with a grade of 173 ppm UO2 and 31.9% P₂O₅. An L/S (liquid to solid ratio) = 5, 3 M sulfuric acid concentration, 80°C temperature, and 5 h leaching time were obtained as the optimum leaching parameters using the response surface methodological approach. The efficiency of uranium recovery from phosphate ore pre-treated by flotation and calcination methods was 84.2% and 75.2%, respectively. The results indicated that flotation has superiority over calcination as a pre-treatment method of phosphate ore in the Sheikh Habil-Iran mine.
Health vs. privacy. How Norwegian public authorities and news media framed the newly developed digital contact tracing app “Smittestopp” under the COVID-19 pandemic
Authors: Karlberg Anne-Maren , Magin Melanie
Published: December 2023

In spring 2020, shortly after the outbreak of the Coronavirus diseases 2019 (COVID-19), Norway introduced the digital contract tracing app “Smittestopp” (“Stop infection”) as a measure to combat the pandemic. The launch was accompanied by scientific uncertainties about the technology: the app had been developed at lightning speed and hardly been tested, and its effects were unclear. It did not become a success, was strongly underused and soon had to be discontinued due to privacy issues. Our study starts from the assumption that in this situation of uncertainty about the technology, combined with and resulting from a lack of user experience, the app's public portrayal was a decisive factor for this outcome. We investigate the framing of “Smittestopp” in press releases by Norwegian public authorities and in news articles. By means of a qualitative content analysis, we identify 11 frames and uncover the opposition between health considerations and privacy concerns as central conflict line. In their press releases, the public authorities did not use frames very strategically. The news media provided diverse frames but at the same time focused relatively strongly on privacy issues that ultimately led to the app's discontinuation.
Development and testing of a transcatheter heart valve with reduced calcification potential
Authors: Weich Hellmuth , Botes Lezelle , Doubell Anton , Jordaan Johan , Lewies Angelique , Marimuthu Prennie , van den Heever Johannes , Smit Francis
Published: December 2023

Introduction

Patients from developing countries who require heart valve surgery are younger and have less access to open heart surgery than those from developed countries. Transcatheter heart valves (THVs) may be an alternative but are currently unsuitable for young patients because of their inadequate durability. We developed and tested a THV utilizing two new types of decellularized bovine pericardial leaflets in an ovine model.

Methods

The two decellularized tissues [one with a very low dose (0.05%) of monomeric glutaraldehyde (GA) fixation and detoxification (DF) and the other without glutaraldehyde (DE)] were compared to an industry standard [Glycar—fixed with the standard dose (0.625%) of glutaraldehyde]. THVs were manufactured with the three tissue types and implanted in the pulmonary position of nine juvenile sheep for 180 days. Baseline and post-explantation evaluations were performed to determine the hemodynamic performance of the valves and their dynamic strength, structure, biological interaction, and calcification.

Results

Heart failure occurred in one animal due to incompetence of its Glycar valve, and the animal was euthanized at 158 days. The gradients over the Glycar valves were higher at the explant than at the implant, but the DE and DF valves maintained normal hemodynamic performance throughout the study. The DF and DE tissues performed well during the mechanical testing of explanted leaflets. Glycar tissue developed thick pannus and calcification. Compared to Glycar, the DF tissue exhibited reduced pannus overgrowth and calcification and the DE tissue exhibited no pannus formation and calcification. All tissues were endothelialized adequately. There was a striking absence of host ingrowth in the DE tissue leaflets, yet these leaflets maintained integrity and mechanical function.

Conclusion

In the juvenile sheep THV model, Glycar tissue developed significant pannus, calcification, and hemodynamic deterioration. Using a very low dose of monomeric GA to fix the decellularized bovine pericardium yielded less pannus formation, less calcification, and better hemodynamic function. We postulate that the limited pannus formation in the DF group results from GA. Bovine pericardium decellularized with our proprietary method resulted in inert tissue, which is a unique finding. These results justify further development and evaluation of the two decellularized tissue types in THVs for use in younger patients.
Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases
Authors: Cao Ce , Li Lei , Zhang Qian , Li Haoran , Wang Ziyan , Wang Aoao , Liu Jianxun
Published: December 2023

Cardiomyocytes fail to regenerate after birth and respond to mitotic signals through cellular hypertrophy rather than cellular proliferation. Necrotic cardiomyocytes in the infarcted ventricular tissue are eventually replaced by fibroblasts, generating scar tissue. Cardiomyocyte loss causes localized systolic dysfunction. Therefore, achieving the regeneration of cardiomyocytes is of great significance for cardiac function and development. Heart development is a complex biological process. An integral cardiac developmental network plays a decisive role in the regeneration of cardiomyocytes. During this process, genetic epigenetic factors, transcription factors, signaling pathways and small RNAs are involved in regulating the developmental process of the heart. Cardiomyocyte-specific genes largely promote myocardial regeneration, among which the Nkx2.5 transcription factor is one of the earliest markers of cardiac progenitor cells, and the loss or overexpression of Nkx2.5 affects cardiac development and is a promising candidate factor. Nkx2.5 affects the development and function of the heart through its multiple functional domains. However, until now, the specific mechanism of Nkx2.5 in cardiac development and regeneration is not been fully understood. Therefore, this article will review the molecular structure, function and interaction regulation of Nkx2.5 to provide a new direction for cardiac development and the treatment of heart regeneration.
Listen to the patients! Identifying CML patients' needs analyzing patient-generated content with AI-driven methodologies
Authors: Scholz Stefanie , Berns Isabell , Winkler Christian
Published: December 2023

Background

Various patient support programs exist to provide successful therapy options for patients. Pharmaceutical companies are increasingly recognizing the importance of actively supporting patients in their long-term treatment. In order to effectively assist patients, it is crucial to understand their current needs by taking a look at the patients' opinions.

Objective

This study focuses specifically on chronic myeloid leukemia (CML) and aims to determine if the current patient engagement offerings from pharmaceutical companies adequately address the needs of CML patients. To achieve this, the study uses content generated by CML patients to assess the patient engagement strategies of selected pharmaceutical companies, explore the relevance of medication, their products, and services, and analyze key concerns from the perspective of the patients.

Methods

To address the research questions, various methodologies were employed. Initially, desk research was conducted to identify relevant pharmaceutical companies and internet forums related to CML. Subsequently, content generated by patients was acquired and AI-driven techniques such as topic modeling and topic evolution analyses were used to examine this user-generated content (UGC) within the identified public forums. This involved analyzing topic models and tracking topic changes over time.

Results

The desk research revealed that pharmaceutical companies primarily offer information about the disease and available treatment options. The UGC analysis confirmed the significant role played by the industry in supporting CML patients. Key areas of interest for patients include the disease itself, potential treatment methods and associated side effects, dosage of active substances, and the possibility of switching therapies due to treatment failure or resistance. Stem cell transplantation was also discussed.

Conclusions

Overall, the pharmaceutical industry adequately addresses the needs of CML patients. However, there is room for improvement in educating patients about treatment options, drugs, and their side effects. Psychological support should not be neglected. Since CML patients frequently engage with clinical trial outcomes, there is potential for increased patient involvement in such trials. Further research in this area is recommended.
Geotechnical factors influencing earth retaining wall deformation during excavations
Authors: Seo Seunghwan , Park Jongjeon , Ko Younghun , Kim Gunwoong , Chung Moonkyung
Published: December 2023

This study aims to identify and evaluate the significance of the key design factors that impact the stability of Earth retaining wall anchor-supported structures during excavations in urban areas. Although there are many previous studies on the deformation of Earth retaining walls during excavation, there is a lack of verification studies that quantitatively examine the stability of various influencing factors such as wall, ground characteristics, and external influencing factors. To this end, finite-element analyses were conducted, and their results were compared and validated with field measurements. These comparisons demonstrated that the numerical modeling technique employed in this study effectively simulates the wall’s behavior under excavation conditions. Subsequently, the impact of the main design factors, including ground properties, external conditions, and structural stiffness, on the behavior of the wall was quantitatively assessed by applying variation ratios. The findings indicate that the horizontal displacement of the wall, induced by excavation, is significantly dependent on the unit weight and shear strength of the soil. Conversely, the groundwater level location, surcharge load, and structural stiffness exhibit a relatively minor effect. Finally, the variability of the main design parameters was investigated, considering the specific ground layer where the wall is installed, revealing distinct influences of these variables across different ground layers. Consequently, it is expected that the importance of the influencing geotechnical factors will be selected and used for predicting the behavior of Earth retaining walls and actual design, which will help to efficient wall design.