bluuebunny/crossref_metadata_2025 huggingface dataset:
CareKnowDo—A Multichannel Digital and Telephone Support Program for People With Chronic Kidney Disease: Feasibility Randomized Controlled Trial
Authors: Reston Riley Elizabeth , Caskey Fergus J , Hole Barnaby , Udayaraj Udaya , Weinman John
Published: January 2023

Background

Chronic kidney disease (CKD) is a common, progressive condition. Lifestyle changes and antihypertensive medication can slow the progression to end-stage kidney disease, which requires renal replacement therapy. However, adherence to these recommendations is often low.

Objective

The aim of CareKnowDo was to assess the feasibility of rolling out a digital self-management support and adherence program integrated with a patient-facing electronic health record, Patient View (PV).

Methods

A 2-arm, parallel, individual-level pragmatic feasibility pilot randomized controlled trial was conducted at 2 National Health Service (NHS) sites in the United Kingdom. A total of 61 patients with CKD were randomized 1:1 into 2 groups and provided with either a new, tailored digital and telephone support program (CareKnowDo: 31/61, 51%) integrated with PV or standard care (PV alone: 30/61, 49%). Quantitative measures included clinical and psychosocial measures. The primary outcomes were feasibility based: recruitment rate, dropout, and the exploration of associations.

Results

Of the 1392 patients screened in local kidney clinics, 269 (19.32%) met the basic inclusion criteria; the first 22.7% (61/269) who met the eligibility criteria were recruited to participate in the study. Of the 69 patients, 23 (38%) patients completed the final 6-month follow-up web-based survey. Reasons for the attrition were explored. A higher belief in the ability of the treatment to control CKD was associated with lower blood pressure at baseline (r=0.52; P=.005), and a higher perceived understanding of CKD at baseline was associated with lower blood pressure at follow-up (r=0.66; P<.001). Beliefs about medicines at baseline were associated with blood pressure at baseline but not at follow-up. This was true for both concerns about medicines (r=0.58; P=.001) and perceived necessity of medicines (r=0.42; P=.03).

Conclusions

A tailored digital and nurse call–based program to enhance support for patients with CKD was piloted in 2 NHS sites and found to be feasible and acceptable. However, to maximize the effectiveness of the intervention (and of future trials), consideration should be given to the target audience most likely to benefit, as well as how to help them access the program as quickly and easily as possible.

Trial Registration

NHS Health Research Authority, IRAS ID 184206; https://www.hra.nhs.uk/planning-and-improving -research/application-summaries/research-summaries/careknowdo-pilot-version-1/
Users’ Reactions to Announced Vaccines Against COVID-19 Before Marketing in France: Analysis of Twitter Posts
Authors: Dupuy-Zini Alexandre , Audeh Bissan , Gérardin Christel , Duclos Catherine , Gagneux-Brunon Amandine , Bousquet Cedric
Published: January 2023

Background

Within a few months, the COVID-19 pandemic had spread to many countries and had been a real challenge for health systems all around the world. This unprecedented crisis has led to a surge of online discussions about potential cures for the disease. Among them, vaccines have been at the heart of the debates and have faced lack of confidence before marketing in France.

Objective

This study aims to identify and investigate the opinions of French Twitter users on the announced vaccines against COVID-19 through sentiment analysis.

Methods

This study was conducted in 2 phases. First, we filtered a collection of tweets related to COVID-19 available on Twitter from February 2020 to August 2020 with a set of keywords associated with vaccine mistrust using word embeddings. Second, we performed sentiment analysis using deep learning to identify the characteristics of vaccine mistrust. The model was trained on a hand-labeled subset of 4548 tweets.

Results

A set of 69 relevant keywords were identified as the semantic concept of the word “vaccin” (vaccine in French) and focused mainly on conspiracies, pharmaceutical companies, and alternative treatments. Those keywords enabled us to extract nearly 350,000 tweets in French. The sentiment analysis model achieved 0.75 accuracy. The model then predicted 16% of positive tweets, 41% of negative tweets, and 43% of neutral tweets. This allowed us to explore the semantic concepts of positive and negative tweets and to plot the trends of each sentiment. The main negative rhetoric identified from users’ tweets was that vaccines are perceived as having a political purpose and that COVID-19 is a commercial argument for the pharmaceutical companies.

Conclusions

Twitter might be a useful tool to investigate the arguments for vaccine mistrust because it unveils political criticism contrasting with the usual concerns on adverse drug reactions. As the opposition rhetoric is more consistent and more widely spread than the positive rhetoric, we believe that this research provides effective tools to help health authorities better characterize the risk of vaccine mistrust.
The Efficacy of Be a Mom, a Web-Based Intervention to Prevent Postpartum Depression: Examining Mechanisms of Change in a Randomized Controlled Trial
Authors: Carona Carlos , Pereira Marco , Araújo-Pedrosa Anabela , Canavarro Maria Cristina , Fonseca Ana
Published: January 2023

Background

Postpartum depression (PPD) is treatable and preventable, but most women do not seek professional help for their perinatal depressive symptoms. One increasingly popular approach of improving access to care is the use of web-based intervention programs.

Objective

The objective of this study was 2-fold: first, to assess the efficacy of Be a Mom, a brief web-based selective or indicated preventive intervention, in reducing depressive and anxiety symptoms of women at high risk for PPD; and second, to examine mechanisms of change linking modifiable self-regulatory skills (ie, emotion regulation, self-compassion, and psychological flexibility) to improved perinatal mental health outcomes.

Methods

This 2-arm, open-label randomized controlled trial involved a sample of 1053 perinatal women presenting high risk for PPD who were allocated to the Be a Mom intervention group or a waitlist control group and completed self-report measures at baseline and postintervention assessments. Univariate latent change score models were computed to determine changes over time in adjustment processes and outcomes, with a multigroup-model approach to detect differences between the intervention and control groups and a 2-wave latent change score model to examine whether changes in processes were related to changes in outcomes.

Results

Be a Mom was found to be effective in reducing depressive (intervention group: µΔ=–3.35; P<.001 vs control group: µΔ=–1.48; P<.001) and anxiety symptoms (intervention group: µΔ=–2.24; P<.001 vs control group: µΔ=–0.43; P=.04) in comparison with the control group, where such changes were inexistent or much smaller. All 3 psychological processes under study improved statistically significantly in posttreatment assessments: emotion regulation ability (Δχ23=12.3; P=.007) and psychological flexibility (Δχ23=34.9; P<.001) improved only in the intervention group, and although self-compassion increased in both groups (Δχ23=65.6; P<.001), these improvements were considerably greater in the intervention group.

Conclusions

These results suggest that Be a Mom, a low-intensity cognitive behavioral therapy program, is a promising first-line intervention for helping perinatal women, particularly those with early-onset PPD symptoms.

Trial Registration

ClinicalTrials.gov NCT03024645; https://clinicaltrials.gov/ct2/show/NCT03024645
User-Chatbot Conversations During the COVID-19 Pandemic: Study Based on Topic Modeling and Sentiment Analysis
Authors: Chin Hyojin , Lima Gabriel , Shin Mingi , Zhunis Assem , Cha Chiyoung , Choi Junghoi , Cha Meeyoung
Published: January 2023

Background

Chatbots have become a promising tool to support public health initiatives. Despite their potential, little research has examined how individuals interacted with chatbots during the COVID-19 pandemic. Understanding user-chatbot interactions is crucial for developing services that can respond to people’s needs during a global health emergency.

Objective

This study examined the COVID-19 pandemic–related topics online users discussed with a commercially available social chatbot and compared the sentiment expressed by users from 5 culturally different countries.

Methods

We analyzed 19,782 conversation utterances related to COVID-19 covering 5 countries (the United States, the United Kingdom, Canada, Malaysia, and the Philippines) between 2020 and 2021, from SimSimi, one of the world’s largest open-domain social chatbots. We identified chat topics using natural language processing methods and analyzed their emotional sentiments. Additionally, we compared the topic and sentiment variations in the COVID-19–related chats across countries.

Results

Our analysis identified 18 emerging topics, which could be categorized into the following 5 overarching themes: “Questions on COVID-19 asked to the chatbot” (30.6%), “Preventive behaviors” (25.3%), “Outbreak of COVID-19” (16.4%), “Physical and psychological impact of COVID-19” (16.0%), and “People and life in the pandemic” (11.7%). Our data indicated that people considered chatbots as a source of information about the pandemic, for example, by asking health-related questions. Users turned to SimSimi for conversation and emotional messages when offline social interactions became limited during the lockdown period. Users were more likely to express negative sentiments when conversing about topics related to masks, lockdowns, case counts, and their worries about the pandemic. In contrast, small talk with the chatbot was largely accompanied by positive sentiment. We also found cultural differences, with negative words being used more often by users in the United States than by those in Asia when talking about COVID-19.

Conclusions

Based on the analysis of user-chatbot interactions on a live platform, this work provides insights into people’s informational and emotional needs during a global health crisis. Users sought health-related information and shared emotional messages with the chatbot, indicating the potential use of chatbots to provide accurate health information and emotional support. Future research can look into different support strategies that align with the direction of public health policy.
A Tablet-Based Aphasia Assessment System “STELA”: Feasibility and Validation Study
Authors: Inamoto Yoko , Mukaino Masahiko , Imaeda Sayuri , Sawada Manami , Satoji Kumi , Nagai Ayako , Hirano Satoshi , Okazaki Hideto , Saitoh Eiichi , Sonoda Shigeru , Otaka Yohei
Published: January 2023

Background

There is an extensive library of language tests, each with excellent psychometric properties; however, many of the tests available take considerable administration time, possibly bearing psychological strain on patients. The Short and Tailored Evaluation of Language Ability (STELA) is a simplified, tablet-based language ability assessment system developed to address this issue, with a reduced number of items and automated testing process.

Objective

The aim of this paper is to assess the administration time, internal consistency, and validity of the STELA.

Methods

The STELA consists of a tablet app, a microphone, and an input keypad for clinician’s use. The system is designed to assess language ability with 52 questions grouped into 2 comprehension modalities (auditory comprehension and reading comprehension) and 3 expression modalities (naming and sentence formation, repetition, and reading aloud). Performance in each modality was scored as the correct answer rate (0-100), and overall performance expressed as the sum of modality scores (out of 500 points).

Results

The time taken to complete the STELA was significantly less than the time for the WAB (mean 16.2, SD 9.4 vs mean 149.3, SD 64.1 minutes; P<.001). The STELA’s total score was strongly correlated with the WAB Aphasia Quotient (r=0.93, P<.001), supporting the former’s concurrent validity concerning the WAB, which is a gold-standard aphasia assessment. Strong correlations were also observed at the subscale level; STELA auditory comprehension versus WAB auditory comprehension (r=0.75, P<.001), STELA repetition versus WAB repetition (r=0.96, P<.001), STELA naming and sentence formation versus WAB naming and word finding (r=0.81, P<.001), and the sum of STELA reading comprehension or reading aloud versus WAB reading (r=0.82, P<.001). Cronbach α obtained for each modality was .862 for auditory comprehension, .872 for reading comprehension, .902 for naming and sentence formation, .787 for repetition, and .892 for reading aloud. Global Cronbach α was .961. The average of the values of item-total correlation to each subscale was 0.61 (SD 0.17).

Conclusions

Our study confirmed significant time reduction in the assessment of language ability and provided evidence for good internal consistency and validity of the STELA tablet-based aphasia assessment system.
Evaluating a Peer-Support Mobile App for Mental Health and Substance Use Among Adolescents Over 12 Months During the COVID-19 Pandemic: Randomized Controlled Trial (Preprint)
Authors: Birrell Louise , Debenham Jennifer , Furneaux-Bate Ainsley , Prior Katrina , Spallek Sophia , Thornton Louise , Chapman Catherine , Newton Nicola
Published: January 2023

BACKGROUND

Although it is well known that adolescents frequently turn to their friends for support around mental health and substance use problems, there are currently no evidence-based digital programs to support them to do this.

OBJECTIVE

The aim of this study was to evaluate the efficacy of the Mind your Mate program, a digital peer-support program, in improving mental health symptoms, reducing the uptake of substance use, and increasing help seeking. The Mind your Mate program consists of a 40-minute web-based classroom lesson and a companion smartphone mobile app. The active control group received school-based health education as usual.

METHODS

A cluster randomized controlled trial was conducted with 12 secondary schools and 166 students (mean age 15.3, SD 0.41 years; 72/166, 43.4% female; and 133/166, 80.1% born in Australia). Participants completed self-reported questionnaires assessing symptoms of mental health (depression, anxiety, and psychological distress), substance use (alcohol and other drug use), and help-seeking measures at baseline and at 6-month and 12-month follow-ups.

RESULTS

Students who received the Mind your Mate program had greater reductions in depressive symptoms over a 12-month period than controls (b=−1.86, 95% CI −3.73 to 0.02; Cohen d=−0.31). Anxiety symptoms decreased among students in the intervention group; however, these reductions did not meet statistical significance thresholds. No differences were observed in relation to psychological distress or help-seeking.

CONCLUSIONS

Small to moderate reductions in depression symptoms were observed among students allocated to receive the Mind your Mate intervention. Although the current results are encouraging, there is a need to continue to refine, develop, and evaluate innovative applied approaches for the prevention of mental disorders in real-world settings.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620000753954; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12620000753954

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/26796
Fake news, covid19 and Twitter – a bibliometric approach (Preprint)
Authors: Naeve Hans Peter , Merkel Sebastian
Published: January 2023

UNSTRUCTURED

Fake News, disinformation and misinformation on health-related topics spread massively. Social media plays a crucial role in their propagation. Among all social media, Twitter was identified as playing the most prominent role, and is also the platform the most investigated by researchers. These issues became even more prevalent since the outbreak of the COVID-19-pandemic. This is also reflected by the global research output. We identified 318 articles published since 2020 in the Web of Science. The total scientific output before the pandemic was only 311 articles, showing the growing interest and productivity in the field. Of all articles on disinformation and twitter since the onset of the pandemic, 38 % were COVID-19-related. A bibliometric analysis was conducted, identifying the most investigated topics, most productive countries, journals and institutions. Thus, an overview about the dynamics and characteristics of this emerging research field was gained.
Bi-LSTM based detection of ADR posts using Korean SNS data (Preprint)
Authors: Lee Suehyun , Lee Chung-Chun , Lee Seunghee , Song Mi-Hwa , Kim Jong-Yeup
Published: January 2023

BACKGROUND

Social networking services (SNS) closely reflect the lives of individuals in modern society and generate large amounts of data. Previous studies have extracted drug information using relevant SNS data. In particular, it is important to detect adverse drug reactions (ADRs) early using drug surveillance systems. To this end, various deep learning methods have been employed, which have studied multiple languages in addition to English.

OBJECTIVE

A cautionary drug that can cause ADRs in elderly patients was selected, and Korean SNS data containing this drug information were collected. Based on this information, we aimed to develop a deep learning model that classifies drug ADR posts based on a Recurrent Neural Network (RNN).

METHODS

In previous studies, ketoprofen, which has a high prescription frequency and thus, was selected as the target drug. Posts were collected from portal site containing information about the drug, and NLP techniques for data written in Korean were applied. Posts containing relevant drug names and ADR word pairs were filtered through association analysis, and training data were generated through manual labeling tasks. So, a Bi-LSTM classification model was generated. The entire process was further verified using aceclofenac.

RESULTS

Among the NSAIDs, Korean SNS posts containing Ketoprofen and Aceclofenac information were secured, and the generic name lexicon, ADR lexicon, and Korean stop word lexicon were generated. In addition, to improve the accuracy of the classification model, an embedding layer was created considering the association between the drug name and the ADR word. In the ADR post-classification test, ketoprofen and aceclofenac achieved 87% and 80% accuracy, respectively.

CONCLUSIONS

Here, we propose a process for developing a model for classifying ADR posts using SNS data. After analyzing drug name-ADR patterns, we filtered high-quality data by extracted posts, including known ADR words based on the analysis. Based on these data, we developed a model that classifies ADR posts. This confirmed that a model that can leverage social data to monitor ADRs automatically is feasible.
Motor Intervention Research Trends for Children with Autism Spectrum Disorder: A Bibliometric Analysis (Preprint)
Authors: Xu Jing , Zhou Daliang , Xu Fei
Published: January 2023

BACKGROUND

Approximately 80% of ASD children struggle with age-appropriate motor skills. Numerous studies in this population have examined the effects of motor intervention on social communication and interaction, executive function, and mental health issues. Whereas heterogeneity in publication prevents researchers from revealing the structure and evolution of this topic.

OBJECTIVE

The objective of this study was to conduct a bibliometric analysis of current publications in order to identify prevalent trends and topics concerning motor intervention for children with autism spectrum disorder.

METHODS

Following a systematic search in the Web of Science Core Collection, we used a new research synthesis framework (systematic mapping and bibliometrics) to (1) analyse literature information (productivity and citations) through performance analysis; and (2) perform network analysis of co-cited references and co-occurring keywords to identify research hotspots, frontiers, and emerging trends.

RESULTS

There were a total of 2,341 scientific publications included. ASD symptoms, intervention strategies, and treatment modalities were recognised as research hotspots. Physical activity, validation, and machine learning were identified as research frontiers.

CONCLUSIONS

Motor impairments may be considered a core symptom in children with ASD in the future. Serious games and Exergames are low-cost and potentially effective interventions and treatments. Machine learning has recently emerged as a promising technology for earlier identification of ASD children. However, the validity of diagnostic and evaluation tools, as well as the dosage and clinical efficacy of emerging technological interventions (e.g., serious games and Exergame), remain debatable. Furthermore, while the development and application of new technologies will become an important emerging trend, low-risk treatment with behavioural or psychological treatments is the preferred treatment for children with ASD.
Top psychiatric hospitals in Thanjavur (Preprint)
Authors: Hospital Nila
Published: January 2023

BACKGROUND

Nila Psychiatric Hospital similarly gives transient treatment, for people who will manage their control and who significantly need to stop their substance.

OBJECTIVE

In a concentrated short-term setting, a patient meets with an admission guide who will evaluate what is happening to precede the beginning of the program.

METHODS

The sort and seriousness of compulsion, its term, and the singular's well-being and life responsibilities ought to all factor into putting the patient in the most ideal program.

RESULTS

Short-term programs fluctuate long, contingent upon the particular requirements of the patient.

CONCLUSIONS

Nila Psychiatric Hospital likewise gives short-term treatment, for individuals who will deal with their moderation and who profoundly want to stop their substance.
Utilization of Gravimetric Satellite Data for Delineating of Subsurface Model of The Purwokerto-Purbalingga Groundwater Basin
Authors: Sehah Sehah , Prabowo Urip Nurwijayanto , Raharjo Sukmaji Anom , Ariska Laila
Published: January 2023

The utilization of gravimetric satellite data has been carried out to delineate the subsurface model of the Purwokerto-Purbalingga Groundwater Basin. Access and processing of satellite gravity anomalies data were carried out to obtain the residual gravity anomalies data. Modeling of the residual gravity anomalies data was conducted along the AA′, BB′, and CC′ trajectories. The modeling results show a basin model filled by alluvial deposits (1.75 g/cm3 and 2.28 g/cm3) with a maximum depth of about 402 m for the AA′ trajectory, 543 m for the BB′ trajectory, and 463 m for the CC′ trajectory. The modeling results show that this alluvial basin is delimited by impermeable and semi-impermeable layers, which include laharic deposits of Slamet Volcano (2.61 g/cm3), andesite lava deposits (2.90 g/cm3), Tapak formation rocks (2.50 g/cm3), breccia rocks of Tapak formation (2.70 g/cm3), and breccia rocks of Halang formation (2.80 g/cm3). The fairly large thickness of alluvial deposits supported by dug-well water tables data and resistivity data indicates that the potential of groundwater in the Purwokerto-Purbalingga Groundwater Basin area is very large. The results of the study are expected to be a solution to overcome droughts that often occur in the Banyumas and Purbalingga regencies, as well as for the development of groundwater-based irrigation.
Quantifying spatiotemporal changes of the urban impervious surface of Dhaka District using Remote sensing Technology
Authors: Abbasi Mahzabin , Popy Samsunnahar , Yumin Tan
Published: January 2023

Dhaka, the capital of Bangladesh, is one of the world's fastest-growing cities where imperviousness expanding in tandem. Therefore, accurate estimation of impervious surfaces is essential for urban planning and management. This paper attempts to quantify the changes of urban impervious surfaces in Dhaka district from 1990 to 2020 using remote sensing technology. Satellite images of 1990, 1995, 2000, 2005, 2010, 2015, and 2020 have been taken from the Landsat TM, ETM+, OLI sensor. Unsupervised classification with k-means clustering and three different RS indices NDVI, NDBI, and BUI was used to delineate the actual impervious area of Dhaka city. This study reveals that due to urbanization a net increase of 67.30 sq. miles impervious area is added to the existing amount over the study period. In 2020 total 300.749 sq. miles which contain 51.02% of the total land were occupied by impervious surfaces compared to the 233.446 sq. miles in 1990. Instantaneously taking appropriate strategies is crucial for sustainable urban growth.
First-order analyses on the role of surface wind in the long-term contraction of the Indo-Pacific warm pool
Authors: Siswandi Andreas , Djamil Yudha Setiawan , Rachmayani Rima , Cahyarini Sri Yudawati , Hendrizan Marfasran
Published: January 2023

Due to its high evaporation rate, the Indo-Pacific Warm Pool (IPWP) is one of the most important drivers of Indonesian weather and climate. Previous studies, based on the Sea Surface Temperature (SST) proxy records, suggest that IPWP in the mid-Holocene era (~6000 years ago) underwent a contraction (colder on its east-west perimeter and warmer on its center) compared to today’s condition. In this research, the role of surface wind in contracting the IPWP was analyzed by checking the coherency between changes in SST, wind-stress magnitude, and evaporation. The Climate Community System Model version 4 (CCSM4) simulated these three physical quantities under the pre-Industrial and mid-Holocene scenarios. In these simulations, an anti-phase relation between SST and wind-stress magnitude indicates an important role for a weaker surface wind in warming the SST in the center of the IPWP (South China Sea and Banda Sea), mainly during boreal autumn. However, a weaker surface wind did not seem to have simultaneously suppressed ocean evaporation to warm the SST, as shown by the phase-lag relation in their monthly climatology. On the other hand, colder SSTs on the east-west perimeter of the IPWP (western coast of Sumatra and northern coast of Papua) are unlikely to be associated with changes in the surface wind following a weak correlation between their SST and wind-stress magnitude
Migalastat como monoterapia oral para la enfermedad de Fabry
Authors: Perretta Fernando Javier , Jaurretche Sebastián
Published: January 2023

Contexto: la enfermedad de Fabry es una patología de depósito lisosomal poco frecuente, ligada al cromosoma X y causada por la deficiencia o ausencia de la enzima ?-galactosidasa-A. La nefropatía, junto con la cardiopatía y el compromiso neurológico de la enfermedad, conduce a una muerte prematura.
Objetivo: esta revisión describe la monoterapia oral con migalastat en pacientes con enfermedad de Fabry y mutaciones “amenables”.
Metodología: una chaperona farmacológica oral denominada migalastat (Galafold®), estabiliza y favorece el pasaje de formas mutadas “amenables” de la enzima hacia los lisosomas, aumentando así su actividad.
Resultados: los estudios de fase III Facets y Attract demostraron seguridad y eficacia en comparación con las terapias de reemplazo enzimático disponibles, alcanzando estabilización de la función renal, reducción de la masa ventricular izquierda y estabilización del biomarcador plasmático Lyso-Gb3.
Conclusiones: migalastat fue generalmente bien tolerado en ambos estudios. Publicaciones posteriores de extensión evidenciaron resultados similares, confirmando la seguridad y la eficacia, tanto en pacientes que previamente se encontraban con terapia de reemplazo enzimático y han sido rotados a migalastat, como también en pacientes que han iniciado migalastat como primer tratamiento.
The Effect of Pop Up Book Media on Increasing Dental Health Knowledge in Elementary School Children
Authors: Re Pudentiana Rr , T Siti Nurbayani , Atmasumarta Tugiman , Lestari Tri Riana , Purnama Tedi
Published: January 2023

Background: Children are a very large group of people and have a high prevalence of dental caries. This is related to the correct tooth brushing behavior data which is 2.8% every day. Dental health promotion is an effort to increase children's knowledge whose success cannot be separated from the method of education and the role of the media. Pop-up book is one of the three-dimensional visual media that can be an alternative as a learning medium. Objective: This study aims to analyze the effect of pop up book media on increasing dental health knowledge of elementary school children. Methods: Pre-experimental research with pretest-posttest control group design. The sampling technique was purposive sampling as many as 64 children, consisting of 32 children in the intervention group and 32 children in the control group. The study was conducted at SDN 03 Cilandak Timur, South Jakarta from September to October 2021. The variable influence on the intervention group was pop up book media and the control group was flipchart media while the affected variable was dental health knowledge. The research instrument used a questionnaire about dental health. Data analysis used the SPSS program with the Paired Sample Test to compare the knowledge scores before and after the intervention and the independent t-test to compare the difference in knowledge scores between the intervention group and the control group. Results: The results of the Paired Sample Test on knowledge in the intervention group obtained p = 0.000 and in the control group was p = 0.182. The results of the independent t-test were obtained p = 0.000. Conclusion: Pop up book media is effective in increasing the dental health knowledge of elementary school children.
Pharmacognostical Standardization, Phytochemical Screening and Antiulcer Activity of Terminalia bellerica
Authors: Upadhyay Srishti , Nagar Jagdish , Mukim Mohammad
Published: January 2023

Context: Terminalia chebula Retz. (Combretaceae) is a medium-sized tree that grows in the wild throughout India. T. chebula has been extensively used in Ayurveda, Unani, and homoeopathic medicine. The fruit has been used as a traditional medicine for a household remedy against various human ailments. Traditionally T. chebula is used to cure chronic ulcer, gastritis, and stomach cancers.

Objective: The present study is to evaluate the antiulcer effect of hydroalcoholic extract of Terminalia chebula fruit.

Materials and methods: In the pharmacognostical, phytochemical and biological evaluation many chemicals, glassware and instruments were used. Different grades of chemicals were used as per the requirement like laboratory reagent (LR), analytical reagents (AR) and HPLC.

Conclusion : The present study has been done to evaluate the antiulcer effect of METB on indomethacin induced ulcer models at various doses. The results obtained from the present study have shown that METB possesses antiulcer effect on indomethacin induced ulcers.  Pre-treatment with METB particularly at a dose of 50mg/kg, 100mg/kg and 200 mg/kg decreases ulcer index, total acidity, total volume of acid secretion and increase in pH when compared with control.
The Review: The Discovery and Development of Amlodipine Drug
Authors: Nabila Putri Elana , Mustika Meilinda , Asra Ridho
Published: January 2023

School of Pharmaceutical Science (STIFARM) Padang, West Sumatra, Indonesia, 25417.
Covid 19 Pandemic Impacts On Online Pharmacy And Offline Pharmacy With Reference To Mumbai Region
Authors: Baburao Ushir Rahul , Dolly Diana Dr. P.
Published: January 2023

The Organization ( Who ) declared COVID-19 a swine flu on March 11, 2020, ushering in a global medical emergency of unprecedented scope and magnitude. The approach by countries all over the world differed slightly, but the provisions of frontline universal health care were characterized as critical to the disease outbreak reaction. COVID-19 had also entailed changes in healthcare service delivery. Respirators are one example of a modification aimed to increase public and care worker safety. Pharmacy services, particularly pharmacy moves of care options, just haven't been immune to change, bringing with them it using set of challenges to consider. Pharmacy services had played a critical role there in situation, and there was a high demand for them. That was expanding both online and offline. Methods applied to limit the effects or downturn of COVID-19, like reduced clinical training or amended user laws, had already produced obtaining the best possible prescriptions the person must've been trying to take just before to arrival at the hospital more difficult, leading to greater rely on independent sources to fulfil medication histories. To limit interaction with patients in ambulatory health centres, liking has transitioned with the use of online vs. printed version treatments, internet shopping, and use of clinic to sleep programmes and other healthcare medication delivery services for discharge prescriptions. An There has been an increased initiative to rectify prescription drug buyout troubles untreated by utilising patient assistance programmes or other inpatient programmes to pay the expenses of treatments for COVID treated cases within certain contexts. This paper examines why COVID-19 must have influenced pharmacy clips of quality healthcare website demand supply there in India.

Purpose: A study is being conducted to determine the impact of the Covid 19 outbreak on online and offline pharmacies in the Mumbai region.
A Comparative review on ginger and garlic with their pharmacological Action
Authors: Daharia Anju , Kumar Jaiswal Vinod , Royal Kabya Pratap , Sharma Himanshu , Kumar Joginath Anuj , Kumar Roshan , Saha Purabi
Published: January 2023

It is a therapeutic aspect of medicinal herbs mentioned here. Herbal plants can treat various diseases and ailments—the list of antioxidant included antioxidant, anti-inflammatory, anti-rheumatic, and circulation enhancer. It would be of great benefit in medical and surgical treatment. Those are fantastic. The promotion of the health system is easier, with medicinal plants than synthetic drugs.
How is the SelfCare Management of Patients with Type II Diabetes Mellitus ?- Characteristics and Knowledge
Authors: Iriana Pramita
Published: January 2023

Background: Diabetes mellitus is a long-term disease characterized by increased blood sugar levels. The number of people with diabetes mellitus in Indonesia continues to increase from year to year. Diabetes control can be done with self care management which can be influenced by the characteristics of diabetics, knowledge, attitudes and behavior. Objective: To find out about the relationship between characteristics and knowledge with self care management in patients with type II diabetes mellitus. Research Methods: Quantitative research with analytical descriptive type and using a cross sectional approach. The population of this study was all patients with type II diabetes mellitus in the Kemyoran District Health Center aged 45 years and over with a sample of 93 respondents and using purposive sampling technique. The instrument used was a questionnaire and analyzed using the Chi-Square test. Results: In this study, the results of the Chi-Square test showed that the variables of age (p=0.013), gender (p=0.764), education (p=0.003), duration of diabetes mellitus (p=0.012) and knowledge (p= 0.005 Conclusion: there is a relationship between age, education, duration of diabetes mellitus and knowledge with self care management of patients with type II diabetes mellitus.
CONCEPTUAL STUDY ON MANAGEMENT OF RAKTARSHA
Authors: Gaudar Shivaraj A , Kumar J Santosh , John P Elizabeth
Published: January 2023

In the present era Arsha has become most common and distressing disease due to Sedentary life style and irregular habits. Raktarshas is one of the bheda of ardraars has which is pittaraktanubandhi. The formation of mamsakura occurs which looks like vatankurasadrasha (Gunjaphalavata ,Vidrumasadrasha). Raktasrava, Shoola,Vibandha, Kandu and  Daha are the characteristic features of Raktars has. Inmodern science Raktarshasiscor related with Bleeding Hemorrhoids. Chronic constipation is almost common cause of bleeding Hemorrhoids. Usually due to chronic constipation more pressure exerted on Hemorrhoidal veins as they have not contained any extra bony support hence it causes friction in the region which leads to varicosity of Hemorrhoidal veins which aa in due to chronic constipation yet strained and burst resulting in bleeding. Ayurvedic physician are treating this disease successfully with indigenous formulations and surgery.
Infertility Patients Related To Menarche Age and Nutritional Status at Halim Fertility Center Clinic Medan
Authors: Tambun Mastaida
Published: January 2023

Objective: This study aims to determine the relationship between Menarche Age and Nutritional Status on infertility patients. Infertility is one of the reproductive health problems that have not been completely resolved. Infertility is defined as the inability to have children or a condition where a married couple has not been able to have children even though they have had sexual intercourse 2-3 times a week for a period of 1 year without using contraception. Infertility affects the psychology of married couples so that it triggers marital problems such as divorce, and relationships that are not harmonious.

Methods: The research method used is quantitative analytic with a case control approach. Case control approach is a research that studies the influence of risk factors (independent) and effect factors (dependent), at the same time. The study was conducted at the Halim Fertility Center/HFC Clinic with the study population consisting of Couples of Childbearing Age (EFA) with the number of samples (Cases and Controls) taken proportionally 1:1, 40 Cases: 40 Controls, so the total sample size was 80 samples.

Results: The results of the bivariate analysis between the age of menarche and the incidence of infertility, statistically the Odds Ratio value was 3.85 (95% CI; 1.38-10.764), meaning that respondents with abnormal menarche age had a 3.85 times greater risk of experiencing infertility compared to respondents who have normal age of menarche. With p-value = 0.016, it means that there is a significant relationship between the age of menarche and the incidence of infertility. It can be concluded that the abnormal age of menarche is a risk factor for infertility. The results of the bivariate analysis between nutritional status and the incidence of infertility statistically obtained the Odds Ratio value of 4.846 (95% CI; 1.43-16.42) meaning that respondents who were obese had a 4.846 times greater risk of experiencing infertility compared to those who were not obese. . With p-value = 0.016, it means that there is a significant relationship between nutritional status and the incidence of infertility. It can be concluded that nutritional status is a risk factor for infertility. The results of the independent variables (age of menarche, and nutritional status) met the candidate requirements for inclusion in the multivariate test.

Conclusion: The factors of age at menarche and nutritional status have a risk for the incidence of infertility in couples of childbearing age at the Halim Fertility Center Clinic in Medan. It can be concluded that the age of menarche and nutritional status have a significant relationship with the incidence of infertility.
Qualitative and Quantitative Screening of Phytochemicals in Polar and Non Polar Solvent Extracts of Stem Bark and Leaves of Saraca Indica
Authors: Gogate Shweta , Mathur Rahul , Raghuvanshi Arpit , Yadav Ashutosh kumar , Dhurve Deepak , Sen Dheeraj Kumar , Raj Divya , Rathi Jagdish
Published: January 2023

The present work can serve as a valuable source of information and provide appropriate standards to establish the quality of this plant material in future prospective study. From the results it is evident that the bark and leaves of Saraca indica contain a significant amount of phytochemicals viz. alkaloid, flavonoids, phenolic, saponins and tannin. The bark of Saraca indica contained relativelely higher amounts of phytochemicals than leaves. The comparative analysis of phytochemicals viz. total alkaloids, flavonoids, phenols, saponins and tannins in different solvent extracts from bark and leaves of Saraca indica
Formulation and Evaluation of Nail Drug Delivery System of Anti Fungal Drug
Authors: Nikhath Misbah , S Sanjana
Published: January 2023

The purpose of this study was to prepare nail lacquer for nail drug delivery system of anti fungal drug in order to improve the physicochemical parameters that influence the drug permeation through a nail plate to reach the systemic circulation and the neighbouring target sites.  The success of local topical therapy for onychomycosis depends on the achievement of effective chemical concentrations into/through the human nail plate; therefore, a suitable antifungal drug must be coupled with an appropriate delivery method. The method should maximize the effect of the active principle by aiding its diffusion into the nail bed to levels exceeding the minimum inhibitory concentration (MIC) against local infection by dermatophytes. Thus, a suitable carrier may be needed to enhance drug penetration through the nail barrier.

The nail lacquer formulations were prepared by simple mixing method and analyzed for non volatile content, gloss, smoothness to flow, drug diffusion studies, and % drug content. Among all formulations, nail lacquer prepared with 2% oxiconazole, 6% nitrocellulose, 1% ethyl cellulose, 15% salicylic acid, 10% propylene glycol and 10% 2-H β-CD exhibited good non volatile content, drug release, drug content estimation and zone inhibition i.e. F4 formulation. The drug release profiles were achieved 93.2% at 12 h. The in vitro ungual permeation studies revealed a good in vitro in vivo correlation. Nail lacquer were substantially stable after 1 month storage at 40±2℃.
A systematic review of the effects of Curcuma longa topical formulations on wound healing
Authors: Sabalingam Sriaandhal , Siriwardhene Malitha Aravinda
Published: January 2023

Topical herbal formulations are gaining more attention in wound healing due to their safety and efficacy. This is a systematic review of the effects of Curcuma longatopical formulations on wound healing. C. longa is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, and wound healing properties. Studies carried outas randomized control trials and clinical trials were included for the analysis of this review. Searches were conducted in PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Google scholar (up to March 2022) with 04 studies meeting the inclusion criteria. All randomized control trials and clinical trials have shown a significant improvement in wound healing. The topical formulations containing C. longa as an ingredient have reportedly improved wound healing in cases of eczema, radiodermatitis, acne vulgaris, atopic dermatitis, ichthyosis vulgaris, senile pruritis, and xerotic skin conditions, according to the studies covered in this review.This review identified some evidence that C. longa extract has good effects for wound healing, in accordance with its use in traditional medicine. To evaluate the impact of C. longa on wound healing, including complications, larger, well-designed randomized control trials are required.
A Review: Phytochemical Investigation and Medicinal Applications of Herb’s
Authors: Padole Nitin , Chandankhede Himanshu , Deshmukh Rupal , Chatakwar Prajakta , Dandekar Shivani , Baheti Jagdish
Published: January 2023

Now a day’s major population over the world is facing the issue of allopathic drug and their adverse effect in treatment of various diseases. Ayurveda is one of the traditional medicinal systems of India. The philosophy behind Ayurveda is preventing unnecessary suffering and living a long healthy life. Herbal medicines have existed world-wide with long recorded history and they were used in ancient Chinese, Greek, and Indian medicine for various therapies purposes.Herbals are one of the best alternativesin treatment of acute and chronic diseases.

In this review different herb has been studied due to its medicinal, pharmacognostic and therapeutic application. This article enlists some commercial and non-commercial Polyherbal all around the world. In which plants, fruits, leaves, seeds and powder of Momordica dioica, Lantana camara L., Curcuma longa,Carthamustinctorius and Acacia catechu has been studied. This article provides a general idea about different herbs, their phytochemical contents, method of extraction and applications in treatment of various diseases.
Analysis on the registration and review system of emergency medical devices in China and abroad in the context of COVID-19
Authors: Xu Yiming , Wu Mingyang , Chen Wei , Ge Siyi , Liang Yi
Published: January 2023

Objective

In the context of COVID-19, the domestic and foreign demand for emergency medical devices, such as medical masks and protective suits, is surging, and it is urgent to complete the registration and review of emergency medical devices with high efficiency and quality, which requires a mature and perfect registration and review system as the support. This paper aims to compare and analyze the domestic and foreign registration and review system of emergency medical device, summarize the good experience, and provide feasible suggestions for improving China's emergency medical device registration and review system.

Method

USA, Canada, Japan and the European Union were selected to make a comparative analysis with China from the aspects of legal system and emergency registration and review procedure by literature research, comparative analysis and other theoretical methods.

Results

The legal system and review mechanism of emergency medical device registration in China have been relatively perfect, but the safety and risk balance mechanism and the comprehensiveness of emergency management measures need to be further improved.

Conclusion

On the basis of maintaining its own institutional advantages, China should learn from foreign experience to further optimize the registration and review system of emergency medical devices, so as to improve the ability of response and implementation of China in public health emergencies.