bluuebunny/crossref_metadata_2025 huggingface dataset:
La enfermedad de los vientos am can mo ik tamcas desde una perspectiva iconotextual. Medicina maya e imágenes medievales en el Chilam Balam de Kaua
Authors: Scandar Florencia
Published: October 2023

En este artículo se aborda de una manera integral el contenido de la página 3 del Chilam Balam de Kaua y sus pasajes paralelos con el objetivo de llegar a una mayor comprensión de la enfermedad de la que aquí se habla, el am can mo ik tamcas. Se estudia el texto, proponiendo una nueva traducción, y se plantean las diferentes interpretaciones que de este se pueden hacer. Se analiza su imagen y se propone un vínculo visual con la imagen del ave y la serpiente de los Beatos medievales. Finalmente, se aborda la relación texto-imagen y la información que ésta nos aporta.
Media w stosunkach międzynarodowych w epoce nadmiaru informacji
Authors: Ociepka Beata
Published: October 2023

The objective of the article is to check the functionality of the leading concepts explaining the role of media in international relations and foreign policy in the fourth era of political communication. The author focuses on the “CNN effect” and “manufacturing consent” concepts to illustrate how the Almond–Lippman consensus was rejected. The study is framed by the idea of globalization of media and uses the cases from the EU (Poland and the Netherlands), the relations with Russia and the recent migration crisis on the Polish–Belarussian border to assess the role and position of media in international relations in the age of information overload. The author concludes that despite the deep mediatization of societies in the 21st century, the governments are able to take charge of the discourses in international communication using their strategic narratives.
Wymiar komunikacyjny konfliktu dotyczącego zmian funkcjonowania władzy sądowniczej w Polsce (2016–2021)
Authors: Skrzypiński Dariusz
Published: October 2023

In 2016 the government of the national-conservative Law and Justice party launched a reform of the Polish justice system. In an effort to increase the effectiveness of its operation, the authorities de facto sought to increase the influence of the executive over the judiciary. Two polarized camps (supporters and opponents of the reforms) were thus formed in the political and media landscapes. Various forms of communication played an important role in their activities. The article is devoted to the analysis of the structure of actors and the instruments they used to promote or disavow the proposed changes, influence public opinion and create the image of themselves and their opponents.
Analysis of egg quality traits and prediction of egg weight in Isa Brown laying hens
Authors: ROTIMI Emmanuel
Published: October 2023

Objective: The objective of this study was to determine the best-fitted regression model for estimating egg weight of Isa Brown laying chickens using external and internal egg parameters.
Materials and Method: Data collected include: egg weight (EWT), egg length (EL), egg diameter (ED), shell thickness (ST), shell weight (SW), albumen height (AH), albumen weight (AW), yolk height (YH), yolk weight (YW) and yolk length (YL). Data were subjected to statistical analysis procedures of SPSS (version 23.0.0). Egg weight was regressed on external and internal egg parameters using forward, backward and full model regression procedures, to determine the combinations of egg parameters that explain variation in the dependent variable.
Results: Results showed that the mean (±SE) of EWT, EL, ED, ST, SW, AH, AW, YH, YW and YL were 60.49±0.47, 4.23±0.03, 2.94±0.02, 1.37±0.01, 6.04±0.05, 1.20±0.01, 36.30±0.39, 1.22±0.02, 15.29±0.15 and 2.32±0.02 respectively. The models of EWT = 30.638+0.582AW+0.571YW and EWT = -14.991+8.779EL+5.493ED+3.686SW are the best fitted regression models for predicting egg weight of Isa Brown laying chickens.
Conclusion: Conclusively, egg weight of Isa Brown laying chickens can be improved through selection for EL, ED, ST and SW trait
Evaluation of different organic fertilizers for improving some agronomic characteristics and essential oil content of Lippia citriodora L.
Authors: TAN Uğur , KURT Mehmet Ali , ARABACI Olcay
Published: October 2023

Objective: The objective of this was to identify the impact of various organic fertilizers on the yield and quality characteristics of Lippia citriodora L. plants and assess their adaptability under the ecological conditions of Aydın. Furthermore, it was also aimed to provide information on the potential of organic fertilizers to enhance crop productivity by minimizing the employment of chemical fertilizers.
Material and Methods: The study was conducted for two years (2018-2019) in Aydın ecological conditions. Six different organic fertilizers and one control were tested in the study, these are microbial fertilizer, animal-based liquid organic fertilizer, solid seaweed fertilizer, animal manure compost, leonardite and plant-based liquid organic fertilizer.
Research Findings: Organic fertilizers have a significant effect on all measured traits as compared to control, it may be due to biofertilizers can increase photosynthetic texture by increasing nitrogen, phosphorus and sulfur uptake, which these elements play an important role in chlorophyll production and required enzymes production. This can be the reason for obtaining positive effect of biofertilizers on plant growth and development.
Conclusion: Overall, findings suggest that the use of humic acid-containing fertilizers and proper organic fertilizer management can improve the growth and yield of Lippia citriodora L. plants.
Baklagil yem bitkilerinde sekonder metabolitlerin tozlaşmadaki etkileri
Authors: ÖZYAZICI Mehmet Arif
Published: October 2023

Bitkiler, otoburlara karşı toksik, itici ve/veya beslenme karşıtı etkileri olan sekonder metabolitlerin sentezini içeren bir dizi savunma stratejisi geliştirmişlerdir. Genel olarak flavonoidler, alkaloidler ve terpenoidler sınıfında yer alan bu sekonder metabolitlerin, bitki savunmasındaki ekolojik işlevi iyi bilinmekte; ancak, bitki-tozlayıcı etkileşimlerindeki rolleri henüz yeterince açık değildir. Mevcut bilgilere göre, çiçeğin nektar ve poleninde bulunan sekonder metabolitler; renk ve koku gibi cezbedici özellikleri ile tozlaşmada aracılık etme, tozlaşmada çok fazla katkısı olmayan böceklerden çiçeği ve nektarı koruma ve mikrobiyal aktiviteleri sayesinde tozlayıcılardaki hastalık etmenlerinin seviyesini azaltma gibi faydaları özellikleri ile tozlaşmada etkili olmaktadır. Bu derleme çalışmasında, baklagil yem bitkilerindeki sekonder metabolitlerin tozlaşmadaki etkileri üzerinde durulmuştur.
A Study on the Distribution Effect of Corporate Income Tax in Korea
Authors:   KOREA DEVELOPMENT ECONOMICS ASSOCIATION, Kang Byung-Goo , Sung Hyo-Yong , Jeong Seeun
Published: October 2023

This study analyzes the effect of corporate income tax on income distribution in Korea. Studies on the economic effects of corporate income tax have mainly focused on investment and employment effects. This research trend is due to the prevailing idea that the investment effect of corporate income tax is decisive, employment and wages are determined incidentally, and that companies are merely conduits for distributing profits to shareholders. However, corporate income tax also affects the labor income share and household income distribution through changes in employment and wages, dividends, and internal reserve fund of a company. If corporate income tax cuts increase investment, but employment growth is weak and real wage growth rates falls short of labor productivity growth rates, the labor income share will decrease and household income inequality will widen. According to the results of the empirical research, the effects of corporate income tax rate on investment and employment are weak. The expanded investment is also capital-intensive, so the employment effect is not significant, and more the real wage increase does not keep up with labor productivity. As a result, a reduction in the effective corporate income tax rate lowers the labor income share and increases income inequality. Therefore, to increase the distribution effect of corporate income tax, corporate income tax should be reformed in a way that supports employment growth and real wage increases while including investment.
PEMBANGUNAN PERTANIAN: SEBUAH KAJIAN PUSTAKA TERSTUKTUR
Authors: Wijaya Wahyu Rizal , Salahudin Salahudin
Published: October 2023

This study aims to examine more deeply about agricultural development. This study uses the systematic literature review method, articles taken from the publications of various publishers using the SCOPUS database and given restrictions on the year of publication only for the last two years or the same as from 2019 to 2021. From the results of this search resulted in 233 views of relevant articles. With this research topic, this figure is obtained from the number of files (.ris) that are exported to Mendeley software. This study explains that agricultural development is currently an integral part of the general public. In agricultural development, it is not only a process or activity of agricultural production but also something that can produce social changes from the scope of values, norms, behavior, institutions, social and so on in order to achieve better economic growth and improve the welfare of farmers and society to become more and more. The limitations of this study are examples of articles presented that differ from the existing conditions in each country so that there is a need for a critical understanding of the government system in the examples of articles that are used as references besides that there needs to be special considerations in determining equations and new findings from articles that are used as reference material to develop the main idea in accordance with the selected topic and title so that the next research needs to understand the main points of the topics that are in accordance with the title and focus on research by adjusting to new things that are to be sought and can be adjusted to the title that is raised.
A Medicaid-Funded Statewide Diabetes Quality Improvement Collaborative: Ohio 2020‒2022
Authors: Bolen Shari D. , Joseph Joshua J. , Dungan Kathleen M. , Beverly Elizabeth A. , Perzynski Adam T. , Einstadter Douglas , Fiegl Jordan , Love Thomas E. , Spence Douglas , Jenkins Katherine , Lorenz Allison , Uddin Shah Jalal , Adams Kelly McCutcheon , Konstan Michael W. , Applegate Mary S. ,   on behalf of the Diabetes Quality Improvement Collaborative
Published: October 2023

We used a collective impact model to form a statewide diabetes quality improvement collaborative to improve diabetes outcomes and advance diabetes health equity. Between 2020 and 2022, in collaboration with the Ohio Department of Medicaid, Medicaid Managed Care Plans, and Ohio’s seven medical schools, we recruited 20 primary care practices across the state. The percentage of patients with hemoglobin A1c greater than 9% improved from 25% to 20% over two years. Applying our model more broadly could accelerate improvement in diabetes outcomes. (Am J Public Health. 2023;113(12):1254–1257. https://doi.org/10.2105/AJPH.2023.307410 )
Wagner y el mito literario de Tristán en "Melancholia", de Lars von Trier
Authors: Mariño Mexuto Marta
Published: October 2023

La presencia del mito literario de Tristán e Isolda en la película de ciencia ficción Melancholia (2011), de Lars von Trier, se deja sentir desde que suenan los acordes de Tristan und Isolde de Wagner. Sin embargo, la relación entre ambas piezas artísticas no se queda ahí, pues la música une a la protagonista con el planeta Melancolía, símbolo de su propia depresión. En efecto, la atracción entre la joven y el astro que está a punto de chocar contra la Tierra se introduce como si se tratase de la historia de los trágicos amantes. Así, la ópera y el filme se unen en un conjunto armónico en el que los fragmentos wagnerianos dotan a la obra de nuevos significados.
Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function
Authors: Walsh Stephen , Siew Keith , Afsari Fatemeh , Al-Jaber Maneera , Allen Noah , Al-Maadheed Mohammed , Altinok Selin , Arif Shehbeel , Bah Nourdine , Baranzini Sergio , Barker Peter , Beheshti Afshin , Blaber Elizabeth , Border Samuel , Boyko Valery , Broni-Tabi Jessica , Burling Keith , Campbell Robert , Cheng-Campbell Margareth , Cheshire Chris , Colon Lorianna , Costes Sylvain , Cubitt Laura , D'Ambrosio Viola , Degoricija Lovorka , Eisch Amelia , Fazelinia Hossein , Figg Nichola , Finch Rebecca , Foox Jonathan , French Alison , Galazka Jonathan , Gebre Samrawit , Gordon Peter , Grillo Alessandra , Houerbi Nadia , Kahrood Hossein , Karouia Fathi , Kiffer Frederico , Kim JangKeun , Klosinska Aleksandra , Kubik Angela , Lee Han-Chung , Li Yinghui , Li Zhongwang , Lucarelli Nicholas , Lynham Steven , Marullo Anthony , Mason Christopher , Matei Irina , Meydan Cem , Mimar Sayat , Mohamed-Ali Vidya , Muratani Masafumi , Naglah Ahmed , Nelson Charlotte , Nestler Kevin , Nicod Jerome , O'Shaughnessy Kevin , De Oliveira Lorraine Christine , Oswalt Leah , Overbey Eliah , Patel Vaksha , Patras Laura Ioana , Polo San-huei , Rodríguez-Lopez María , Rodriques Samuel , Roufosse Candice , Sadeghi-Alavijeh Omid , Sanchez-Hodge Rebekah , Sanders Lauren , Sankar Anindya , Sarder Pinaki , Schisler Jonathan , Schittenhelm Ralf , Schweickart Annalise , Scott Ryan , Shiba Dai , Sian Terry Lim Kam , Silveira Willian , Slawinski Hubert , Smith Scott , Snell Daniel , Sosa Julio , Steele Joel , Tabetah Marshall , Tanuwidjaya Erwin , Uruno Akira , Vaughan Michael , Walker-Samuel Simon , Wan Elizabeth , Yamamoto Masayuki , Yang Xiaoping , Yasmin Yasmin , Yun Sanghee , Zhang Haijian , Dai Zhongquan , Zimmermann Jasminka , Zwart Sara , A.C.Almeida Eduardo , Zhong Chutong
Published: October 2023

Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.

We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions.

We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.
Analytical and Fractional Model for Power Transmission of Lossy Transmission Line
Authors: Abro Kashif Ali , Soomro Amir Mahmood , Larik Abdul Sattar
Published: October 2023

A lossy transmission line can draw current from DC source if DC voltage is applied to constant resistance that’s why surge impedance become uniform on lossy transmission line. This manuscript proposes the analytical and fractional modeling of lossy transmission line based on partial differential equations by employing Kirchoff’s current and voltage laws via Fourier analysis. The governing equation of lossy transmission line is fractionalized by means of modern fractional differential operators. The optimal solution of voltage is investigated by means of Fourier sine and Laplace transforms subject to the imposed conditions. The investigated solutions of voltage over the transmission line have been established in terms of exponential and gamma functions. The comparative analysis of voltage over the transmission line through Caputo-Fabrizio and Atangana-Baleanu fractional operators have been presented for line losses on the conductance, resistance and inductance for the confirmation of the principle of electric power transmission.
A Study of Obesity and Financial Stress in Workers in the United States: Findings from the NHIS 2021A Study of Obesity and Financial Stress in Workers in the United States: Findings from the NHIS 2021
Authors: Weissman Judith , Rogol Naomi , Jay Melanie , Taylor John
Published: October 2023

Purpose
This cross-sectional study examined the relationship between indicators of workplace financial stress and obesity among working adults.
Methods
Respondents were sampled from the 2021 National Health Interview Survey. Adults were included if they worked in the last week were between 18 to 65 years (n = 14, 976). A multivariable model predicted having obesity using the following the independent variables: working full time, defined as working 35 hours per week or more, working while sick, perceived likelihood of job loss, food insecurity and sociodemographic characteristics. The multivariable model was based on bivariate analyses comparing these variables, and serious psychological distress to having obesity and the number of chronic health conditions.
Results
At the bivariate level 6.5% of full-time workers had food insecurity, and 9.1% perceived they were fairly or somewhat likely to lose their job and 45% with obesity had serious psychological distress. In a multivariable model, there was a positive association between obesity and full-time employment (AOR = 1.5 CI = 1.3, 1.7), workers perceptions of being fairly or somewhat likely to lose their job (AOR = 1.2 CI = 1.0, 1.4), and obesity and food insecurity (AOR = 1.2 CI = 1.0, 1.4) after adjusting for sociodemographic characteristics.
Conclusions
Working adults with obesity likely work full time, have serious psychological distress, and perceive a likely job loss. Despite working full time, many adults experienced food insecurity.
Interactive Decision Tree based Fuzzy-Proportional Integral Derivative Controller for Reactive Power Compensation using STATCOM for Non-linear Loads
Authors: S Rajendran , A Muthu Kumar , S kannan
Published: October 2023

The STATCOM is extensively used in the power system to address the voltage sag and other power quality issues that arises due to the inductive and nonlinear loads. The STATCOM uses a power electronics system with a voltage and current controller to actively compensate the reactive power requirements of the load. The STATCOM’s performance depends on the underlying controller operation. Consequently, controllers that can handle sudden load changes and disturbances optimally with faster response is desired. For this purpose, this investigation presents a controller design that handles nonlinear load and ensures optimal operation. The proposed controller consists of a fuzzy-PID controller that is capable of handling non-linear dynamics and sudden changes in the load. In order to tune parameters, the bio-geography based optimization method used to determine the fuzzy-PID controller parameters that minimizes the integral absolute error of the controller. Furthermore, a single objective function is formulated on top of the fuzzy-PID controller. It consists of importance weighted performance metrics such as integral squared error and integral absolute errors of the voltage and current controllers, respectively. The significance weights are determined by interactive decision tree technique to detect weaker metrics and improve their influence in the control scenarios. The algorithm terminates once all the metrics are tuned to satisfaction with operator’s consent. The proposed IDT based fuzzy PID controller is tested on a power system containing nonlinear load, and its performance is compared with existing controller. The proposed controller improves the reactive power compensation offered by the STATCOM significantly.
Neuroprotective activity of chlorogenic acid from Brazilian Arnica in rodents subjected to status epilepticus induced by lithium-pilocarpine
Authors: Carreño-González Alberth Jonathan , Liberato José Luiz , Celani Marcus Vinicius , Lopes Norberto Peporine , Lopes João Luís Callegari , Neto Leonardo Gobbo , Fontana Andreia C. K. , Santos Wagner Ferreira dos
Published: October 2023

In this study, we evaluated the neuroprotective properties and antioxidant effects of chlorogenic acid (CGA) in Wistar rats subjected to Status Epilepticus (SE) model using lithium-pilocarpine. After 72 h induction of SE, brains were collected and studied histologically for viable cells in the hippocampus with staining for cresyl-violet (Nissl staining), and for degenerating cells with Fluoro-Jade C (FJC) staining. Additionally, to evaluate oxidative stress, the presence of malondialdehyde (MDA), the final product of lipid peroxidation, and superoxide dismutase (SOD), the enzyme responsible for the conversion of superoxide anion radicals, were quantified using the Indole and the Pyrogallol methods, respectively.
Animals administered with CGA (30 mg/kg) demonstrated a significant decrease of 59% in the number of hippocampal cell loss in the CA3, and of 48% in the hilus layers after SE. A significant reduction of 75% in the cell loss in the CA3, shown by FJC+ staining, was also observed with the administration of CGA (30 mg/Kg). Furthermore, significant decreases of 49% in MDA production and 72% in the activity of SOD were seen, when compared to animals subjected to SE that received vehicle. This study suggests that CGA administration results in an effective inhibition of the proliferation of oxidizing agents that can initiate cellular death, in the lithium-pilocarpine Status Epilepticus (SE) rat epilepsy model.
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Authors: Liang Xiuming , Gupta Dhanu , Xie Junhua , Wonterghem Elien , Hoecke Lien , Hean Justin , Niu Zheyu , Wiklander Oscar , Zheng Wenyi , Wiklander Rim , He Rui , Mammad Doste , Bost Jeremy , Zhou Guannan , Zhou Houze , Roudi Samantha , Zickler Antje , Gorgens Andre , Hagey Daniel , de Jong Olivier G , Uy Aileen , Zong Yuanyuan , Mager Imre , Perez Carla , Roberts Thomas , Vader Pieter , Fougerolles Antonin , Wood Matthew , Vandenbroucke Roosmarijn , Nordin Joel , El-Andaloussi Samir
Published: October 2023

Intracellular delivery of protein and RNA therapeutics represents a major challenge. Here, we developed highly potent engineered extracellular vesicles (EVs) by incorporating essential bio-inspired attributes required for effective delivery. These comprise engineered mini-intein proteins with self-cleavage activity for active cargo loading and release, and fusogenic VSV-G protein to activate productive endosomal escape. Combining these components allowed high efficiency recombination and genome editing in vitrofollowing EV-mediated delivery of Cre recombinase and Cas9/sgRNA RNP cargoes, respectively. In vivo, single dose EV-mediated Cre delivery to the brains of Cre-LoxP R26-LSL-tdTomato reporter mice resulted in greater than 40% and 30% recombined cells in hippocampus and cortex respectively. In addition, we demonstrate therapeutic potential of this platform by showing inhibition of LPS-induced systemic inflammation via delivery of a super-repressor of NF-ĸB activity. Our data establish these engineered EVs as a novel platform for effective delivery of multimodal therapeutic cargoes, including for efficient genome editing.
A case report on Para-kala-azar dermal leishmaniasis: an unresolved mystery
Authors: Hasan Md. Mehedi , Proma Sanghita Banik , Hossain Saddam , Arifuzzaman Md. , Islam Naylla , Sidduque Abu Bakar , - Amiruzzaman
Published: October 2023

BACKGROUND:
Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis that occurs 2-3 years after an apparently successful treatment of visceral leishmaniasis (VL). In rare cases, PKDL occurs concurrently with VL and is characterized by fever, splenomegaly, hepatomegaly or lymphadenopathy, and poor nutritional status and is known as Para-kala-azar dermal leishmaniasis (Para-KDL). Co-association of active VL in PKDL patients is documented in Africa, but very few case reports are found in South Asia.
CASE SUMMARY:
We present a case of Para-kala-azar Dermal Leishmaniasis (Para-KDL) in a 50-year-old male patient with a history of one primary Visceral Leishmaniasis (VL) and 2 times relapse of Visceral Leishmaniasis (VL). The patient presented with fever, skin lesions, and hepatosplenomegaly. Laboratory tests revealed LD bodies in the slit skin smear and splenic biopsy. The patient was treated with two cycles of Amphotericin B with Miltefosine in between cycles for 12 weeks to obtain full recovery.
CONCLUSION:
This case report serves as a reminder that Para-kala-azar dermal leishmaniasis can develop as a consequence of prior visceral leishmaniasis episodes, even after apparently effective therapy. Since para-kala-azar is a source of infectious spread, endemics cannot be avoided unless it is effectively recognized and treated.
First real-world time-travel experiment shows ecosystem collapse due to climate change
Authors: Li Guandong , Tornqvist Torbjorn , Dangendorf Sönke
Published: October 2023

Climate impacts throughout the 21st century are multifaceted and include heat stress, water scarcity, flood risk, and a threat to biodiversity and ecosystems. Predicting these impacts has been challenging, even if the trajectory of climate change is precisely known. To date, recourse has commonly been taken to modeling and paleoclimate studies, but these approaches have significant limitations. Here we examine coastal ecosystem change during 12 years of unusually rapid, albeit likely temporary, sea-level rise (> 10 mm yr− 1) in the Gulf of Mexico. Such rates, which may become a persistent feature in the future due to anthropogenic climate change, drove rising water levels of similar magnitude in coastal Louisiana and thus affected the ~ 15,000 km2 of coastal wetlands in this region. Measurements of surface-elevation change at 253 monitoring sites show that 87% of these sites are unable to keep up with rising water levels. We find no evidence for enhanced wetland elevation gain through ecogeomorphic feedbacks, where more frequent inundation would lead to enhanced biomass accumulation that could counterbalance rising water levels. We attribute this to the exceptionally rapid sea-level rise during this time period. Under the current climate trajectory (SSP2-4.5), drowning of ~ 75% of Louisiana’s coastal wetlands is a plausible outcome by 2070.
A New Lifetime Model: Statistical Properties and Applications
Authors: Singh Pawan Kumar , Pandey Arvind , Mahto Amulya Kumar , Mutairi Aned Al , Nassr Said G. , Mustafa Manahil SidAhmed , Mekiso Getachew Tekle
Published: October 2023

In this paper, we introduce a new lifetime distribution. Characteristics and statistical properties are obtained, such as stress strength reliability, moments, entropy, and order statistics. Moreover, the estimation of the parameter of the proposed distribution for the complete sample are discussed using different estimation methods like percentiles, least squares estimation, weighted least squares estimation, maximum likelihood estimation, and Cramer-von-mises estimations and compared them using Monte Carlo simulation study. The model parameter is obtained under hybrid censoring based on the censored sample. The actuarial measures are calculated for our model and the result is compared with the risk of the exponential distribution. Finally, an application of two real data sets is used to illustrate the proposed model.
Decomposing dynamical subprocesses for compositional generalization
Authors: Luettgau Lennart , Erdmann Tore , Veselic Sebastijan , Stachenfeld Kimberly , Moran Rani , Kurth-Nelson Zeb , Dolan Raymond
Published: October 2023

Our experiences of the world usually reflect the interaction of multiple dynamical subprocesses. For example, clothes' appearance follows a complicated trajectory that is composed of factors such as becoming dirtier with wear and the colors fading slowly over time. In principle, decomposing these subprocesses can enhance learning efficiency, reduce memory requirements, and facilitate compositional reuse in new environments. This is because identical subprocesses can appear in other contexts, for example, discovering that colors in printed photographs also fade over time. Here, we combined a novel sequence learning task with computational modeling to test whether humans (N = 238) extract subprocesses from their holistic experiences, abstract these away from mere sensory experience, and efficiently recompose this knowledge to solve new problems. In a prior learning phase, two groups of participants were each exposed to sequences of compound images drawn from the product space of two graphs: G1 and G2 for group 1, G3 and G4 for group 2. Subsequently, in a transfer learning phase, all participants experienced compound images that were the product of G1 and G3 but composed of entirely new images. We found that knowledge of subprocesses transferred between tasks such that in a new task environment each group made more accurate predictions pertaining to the structure they had experienced in prior learning. Computational models utilizing predictive representations, based solely on the temporal contiguity of experienced task states, could not explain these data. Instead, behavior was consistent with a model performing structural inference over a hypothesis space of graph structures. Our results provide support for the idea that humans discover and abstract subprocesses from dynamic environments and reuse this knowledge to meet the demands of new environments in an efficient, resource-rational manner.
Operational cycle analysis of Colombian sugarcane harvest, transport and unloading systems
Authors: Salazar Bryan Antonio , Lozano-Moreno Jairo Alexander , Clavijo-Buritica Nicolas
Published: October 2023

This paper addressed the cycle analysis of the Colombian sugarcane harvest, transport, and unloading system, providing evidence to highlight the synchronization of the machinery as the main bottleneck. The paper's uniqueness to previously published results lies in the holistic approach adopted, integrating operational, economic, and environmental performance indicators. The solution approach considered a set of mathematical formulations and logical rules that feed three perspectives of analysis (operational, economic, and environmental). Consequently, the computational models for each perspective are called ‘modules’ and generate the performance measures. The preliminary analytical results showed low utilization rates for all system resources and a significant difference between the sugarcane harvested and the volume transported to the mill. A sensitivity analysis was conducted using different scenarios to study the impact of machinery synchronization on the system performance. In summary, the main results show that the maximum use of the harvester will be achieved by two tractors in the cycle. Consequently, the operational cost and energy consumption will increase. Besides, the number of wagons per truck will positively influence the system's performance. Although larger truck fleets will improve the system capacity, a deeper financial analysis becomes necessary due to the intense capital investment.
The Influence of Event Stimulation on Consumers' Purchase Behavior with Health Agricultural Products in the Digital Era: A Case Study of the Selenium-enriched Fraud
Authors: Song Zhenjiang , Luo Xin , Wu Baoshu , Zhu Shubin
Published: October 2023

Background: Understanding consumers' behavioral choices after the stimulus of negative events has great significance for repairing consumer perceptions, improving crisis management strategies for negative events, and promoting the food industry’s healthy development.
Methods: Based on the "stimulus-organic-response" (SOR) theory, this study constructed a consumer purchasing-behavior model stimulated by negative events and analyzed the influence mechanism of internal stimulus, external stimulus, and consumer characteristics on consumers' negative emotions and selenium-enriched agricultural products purchasing behavior.
Conclusions: The empirical analysis produced the following conclusions. ① Negative perceptions and media disclosure not only can directly predict consumers' purchasing behavior with Se-enriched agricultural products but can also predict consumers' purchasing behavior with Se-enriched agricultural products through the mediating effect of negative emotions. ②There is no effect of negative emotion between preferences and consumers' purchase of Se-enriched agricultural products. This is explained by the current online and offline purchase channels, which expand the space of consumer choice. Additionally, in the digital era, consumers are more likely to obtain product information and guidance from relatively professional or targeted opinions, and their purchasing preferences tend to be decentralized and personalized. The influence of lay belief, impulse buying, and herd behavior on consumer purchasing has gradually decreased. ③ External intervention cannot moderate the relationship between negative emotion and purchase. Findings indicated that in the digital era, the rise of we-media, the reduction of information-acquisition cost, and the rise of anti-authority thoughts all lead consumers to distrust authority interventions and consequently, they were more inclined to trust the opinions of non-institutional and non-academic opinion leaders such as celebrities with massive followings.
Comprehensive analysis of genomic complexity in the 5’ end coding region of the DMD gene in patients of exons 1-2 duplications based on long-read sequencing
Authors: Shen Jiandong , Ding Taoli , Sun Xueping , Yang Ji , Zhang Yue , Wang Jing , Ge Mengdi , Xu Heng , Xie Jiazi , Wang Fei , Diao Feiyang
Published: October 2023

Backgroud
Dystrophinopathies are the most common X-linked inherited muscle diseases, and the disease-causing gene is DMD. Exonic duplications are common type of pathogenic variants in DMD gene, however, 5’ end exonic duplications containing exon 1 are less common. When assessing the pathogenicity of exonic duplications in the DMD gene, consideration must be given to their impact on the reading frame. Traditional molecular methods, such as multiplex ligation-dependent probe amplification (MLPA) and next generation sequencing (NGS), are commonly used in clinic. However, they cannot discriminate the precise physical locations of breakpoints and structural features of genomic rearrangement. Long-read sequencing (LRS) can effectively overcome this limitation.
Results
We report three cases involving the duplications of exon 1 and/or exon 2 in DMD gene. The locations of the breakpoints and the characteristics of structural variants (SVs) are identified through LRS, enabling the classification of the variants' pathogenicity. Two distinct variant types encompassing exon 1 in the DMD Dp427m isoform and/or Dp427c isoform are identified, which have been infrequently reported previously. The male individuals harboring duplication variant of consecutive exons 1–2 in the DMD canonical transcript (Dp427m) and exon 1 in the Dp427c transcript are normal, indicating the variant is benign. However, one patient carries a complex SVs involving exon 1 of the DMD Dp427c transcript showing an obvious phenotype.
Conclusions
Our research sheds light on the complexity of DMD variants encompassing Dp427c/Dp427m promoter regions and emphasizes the importance of cautious interpretation when assessing the pathogenicity of DMD 5' end exonic duplications, particularly in carrier screening scenarios without an affected proband.
Cross-shore parallel tidal channel systems formed by alongshore currents
Authors: Xu Fan , Zhou Zeng , Wei Yizhang , Geng Liang , Zhang Ying , Gu Yuxian , Finotello Alvise , D'Alpaos Andrea , Gong Zheng , Zhang Changkuan , Coco Giovanni
Published: October 2023

Tidal channel systems arising from morphodynamic interactions exhibit a suite of diverse morphological configurations. A prevalent type is represented by linear dendritic channels formed by single-thread streams aligned roughly parallel or subparallel to each other in the cross-shore direction. Despite their ubiquity, the processes driving the formation of these parallel channel systems remain elusive. We conducted a morphological analysis of 275 parallel tidal channels from 20 different locations worldwide and found that the angle between individual parallel branches and the parent stream, from which they develop, consistently falls within the range of 80-100º. We employed numerical modeling to shed light on the underlying mechanisms governing their formation, revealing that alongshore uniformity in bed topography and the strength of tidal currents condition the alignment of parallel channels. Cross-shore parallel channels can be formed by alongshore tidal currents, and the channel orientation is largely governed by the shape of the bed profile. Straight and shore-normal parallel branches tend to form where the bed profile changes sharply around the mean sea level, while linearly sloping profiles lead to oblique parallel branches. By unraveling the physics underlying the formation of these striking but poorly understood geomorphic features, our results bear significant ramifications for the understanding and management of valuable tidal ecosystems.
A new evidence base to document millennial changes in coastal vegetation
Authors: Foster Nicole , Jones Alice , Serrano Oscar , Lafratta Anna , Lavery Paul , Dijk Kor-jent Van , Biffin Ed , Gillanders Bronwyn , Young Jennifer , Masque Pere , Gadd Patricia , Jacobsen Geraldine , Zawadzki Atun , Greene Andria , Waycott Michelle
Published: October 2023

Anthropogenic activities are causing detrimental changes to coastal plants– namely seagrass, mangrove, and tidal marsh. Looking beyond recent times and to past vegetation dynamics is critical to assess the response and resilience of an environment to change. Here, we develop a novel multi-proxy approach, providing a new evidence base to decipher long-term change in coastal plant communities. Combining targeted environmental DNA analysis with chemical analysis of soils, we reconstructed 4,000 years of change at a temperate wetland and identified an ecosystem shift that occurred between ~ 1000 and 2000 years ago. What was a previous subtidal seagrass system shifted to an intertidal mangrove environment at present. We demonstrate that high-resolution information on millennial changes in coastal vegetation can be attained through these proxies. This approach could be applied to other ecosystems to improve the way we protect, conserve, and restore vegetated ecosystems.
PKC beta inhibitor prevents renal ischaemia‒reperfusion injury by affecting macrophage infiltration and polarization
Authors: Li Chun Yan , Guo Shuiming , Xiao Ting , Chen Ying , Shushakova Nelli , Haller Hermann , Tian Mei , Rong Song
Published: October 2023

Background
Acute kidney injury (AKI) secondary to renal ischemia reperfusion injury (RIRI) continues to be a significant perioperative problem and there is no effective treatment.
We previously reported that proteinkinase (PKC) β inhibitor could attenuate RIRI after kidney transplantation in rats. However, the mechanism by which PKC β inhibitor protects against RIRI remains unclear.
Methods
RIRI [Ed1] model rats were subjected to right nephrectomy and clipping of the left renal pedicle for 60 minutes. The PKC β inhibitor was orally administered the day before surgery. The rats were sacrificed 24 hours after the operation, and blood and kidney samples were collected. Renal function, histomorphology, renal tubular injury marker KIM-1，renal papillary injury indicator RPA-1，macrophage subtype markers and inflammatory cytokines were analysed.
Results
The results showed that the PKCβ inhibitor had a protective effect against RIRI, as indicated by the attenuation of renal dysfunction and a reduction in renal injury. In addition, the PKC β inhibitor significantly reduced the expression of the M1 macrophage marker CD197 and increased the expression of the M2 macrophage marker CD163[Ed2] . The expression of the proinflammatory cytokines iNOS and IL-12 was downregulated, while the expression of the anti-inflammatory cytokines Arg-1 and Dectin-1 was upregulated by the PKCβ inhibitor.
Conclusions
The PKCβ inhibitor can alleviate RIRI in rats to some extent, which may be related to improve tubular damage in ischemic renal tissue and promoting the polarization of macrophages to the M2 phenotype.
Prediction for incremental damage on final optics in ICF high power laser facility
Authors: Hu Xueyan , Zhou Wei , Guo Huaiwen , Huang Xiaoxia , Zhao Bowang , Zhong Wei , Zhu Qihua , Chen Zhifei
Published: October 2023

High power laser facility requires prediction for incremental damage on final optics in order to find varying damage developing trends, then in terms of the trends we can appropriately formulate maintain plans for long-term physical experiment operation on the facility. This essay indicates an image process technology via deep learning. By comparing fit offline optics image with online optics image, the authenticity and the area of the damage can be correctly defined. Besides, due to the comparison we can establish a damage detection model. Through appropriate algorithm and image matching technology, we could manage element damages on the timeline. And the damage varying trends could be found when additionally combined experimental parameter with analysis on specific damage area. Thus the surplus value of assembly can be optimized. By programming a software for elements management this technology could be used on high power laser facility.
DDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Authors: Pines Alex , Schiffmacher Diana Llerena , Lee Shun-Hsiao , Kliza Katarzyna , Theil Arjan , Akita Masaki , Helfricht Angela , Bezstarosti Karel , Gonzalo-Hansen Camila , Attikum Haico van , Vries Matty Verlaan-de , Vertegaal Alfred , Hoeijmakers Jan , Marteijn Jurgen , Lans Hannes , Demmers Jeroen , Vermeulen Michiel , Sixma Titia , Ogi Tomoo , Vermeulen Wim
Published: October 2023

Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA polymerase II at DNA lesions, which triggers the assembly of the TC-NER-specific proteins CSA, CSB and UVSSA. CSA, a WD40-repeat containing protein, is the substrate receptor subunit of a cullin-RING ubiquitin ligase complex composed of DDB1, CUL4A/B and RBX1 (CRL4CSA). Although ubiquitination of several TC-NER proteins by CRL4CSA has been reported, it is still unknown how this complex is regulated. To unravel the dynamic molecular interactions and the regulation of this complex, we applied a single-step protein-complex isolation coupled to mass spectrometry analysis and identified DDA1 as a CSA interacting protein. Cryo-EM analysis showed that DDA1 is an integral component of the CRL4CSA complex. Functional analysis revealed that DDA1 coordinates ubiquitination dynamics during TC-NER and is required for efficient turnover and progression of this process.
Cerevisterol and aloesol from a marine derived Penicillium fungus as potential topical cosmeceutical ingredients
Authors: Hoang Chi K. , Tran Ha T.H. , Tran Hang T.N. , Hoang Diep T. , Le Cuong H.
Published: October 2023

• Background
The use of natural products in cosmetics and pharmacy has dramatically increased in recent years, leading to the overexploitation of flora and fauna worldwide and threatening environmental sustainability. Microbial-derived components could help solve this problem owing to their independently controllable cultural properties.
• Results
For the purpose of investigating microfungi for producing potential novel cosmeceuticals, cerevisterol (1) and aloesol (2) were isolated from a Penicillium fungus and tested for biological properties, including antimicrobial, tyrosinase inhibitory and wound healing activities. The results revealed wound-healing potentials of two fungal compounds (1) and (2) in terms of cell proliferation promotion in NIH-3T3 murine fibroblasts and scratch assay on 24-well plates using SPLScar™ Scratcher. Interestingly, the filamentous fungus-originated cerevisterol exhibited antimicrobial activity against the acne-causing bacteria Propionibacterium acnes and an inhibitory effect against tyrosinase in substrate L-tyrosine with IC50 = 51.98 µM. In addition, (1) and (2) were found to enhance the wound closure rates of the fibroblast monolayer after 72 h of incubation by up to 19.86–24.82% compared to the vehicle control.
• Conclusions
The results opened new prospects for the application of filamentous fungus-derived compounds, especially in the cosmetics industry.
Causality of Genetically Determined Monounsaturated Fatty Acids on Risk of Cardiovascular Disease: A Mendelian Randomization Study
Authors: Mansourian Marjan , Habibi Danial , Akbarzadeh Mahdi , Teymoori Farshad , Fateh Sahand Tehrani , Masjoudi Sajedeh , Saeidian Amir Hossein , Hosseinpanah Farhad , Mosavi Noushin , Hakonarson Hakon , Azizi Fereidoun , T. Alireza Soleymani , Hedayati Mehdi , Daneshpour Maryam
Published: October 2023

Background/Aim:
We performed the Mendelian randomization (MR) analysis to determine the causal relationship of serum monounsaturated fatty acids (MUFAs) with the risk of various cardiovascular diseases (CVDs).
Method:
The summary statistics dataset related to serum MUFAs was used from the published GWAS of European descent in UK Biobank participants (N=114,999). Genetic variants underlying angina, atherosclerotic, IHD, MI, and BP events were ascertained using a GWAS dataset of 461,880 (case= 14,828, control= 447,052), 463,010 (case= 12,171, control= 450,839), 361,194 (case= 20,857, control= 340,337), 462,933 (case= 10,616, control= 452,317), and 461,880 (case= 124,227, control= 337,653) European descent participants from the UK Biobank, respectively.
Results:
Our results show that MUFAs were associated with angina [ORIVW= 1.005, 95% CI: 1.003–1.007, p = <0.001; Cochran's Q=23.89, p=0.717, I2=0.0%; Egger intercept= -0.0003, p=0.289], atherosclerotic [ORIVW= 1.005, 95% CI: 1.003–1.007, p = <0.001; Cochran's Q=42.71, p=0.078, I2=27.4%; Egger intercept= -0.0004, p=0.146], IHD [ORIVW= 1.004, 95% CI: 1.001–1.007, p = 0.005; Cochran's Q=42.75, p=0.172, I2=18.1%; Egger intercept= -0.0001, p=0.827], MI [ORIVW= 1.001, 95% CI: 0.999–1.003, p = 0.199; Cochran's Q= 23.03, p=0.631, I2=0.0%; Egger intercept= -0.0003, p=0.196], and BP [ORWM= 1.008, 95% CI: 1.001–1.015, p = 0.022; Cochran's Q= 52.87, p=0.015, I2= 37.6%; Egger intercept= 0.0002, p=0.779]. These results remained consistent using different MR method and sensitivity analyses.
Conclusion:
These findings prompt significant questions about the function of MUFAs in the progression of CVD events. Further research is required to elucidate the connections between MUFAs and CVD to contribute to health policy decisions in reducing CVD risk.