bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical Coherence Tomography-Based Grading of Diabetic Macular Edema Is Associated with Systemic Inflammatory Indices and Imaging Biomarkers
Authors: Yanxia Chen , Xiongyi Yang , Min Fu , Xiaoyun Ke
Published: January 2024

Introduction: Objectives of the study were to investigate the correlation between optical coherence tomography (OCT)-based grading of diabetic macular edema (DME) and systemic inflammatory indices, imaging biomarkers, and early anti-vascular endothelial growth factor (VEGF) treatment response. Methods: A total of 111 eyes from 111 patients with DME treated with intravitreous anti-VEGF therapy for 3 consecutive months every month were enrolled in this retrospective study. According to a protocol termed “TCED,” DME was divided into early, advanced, severe, and atrophic stages. The best-corrected visual acuity (BCVA), subretinal fluid (SRF), and the number of hyperreflective foci (HRF) in the whole retinal layers were analyzed at baseline and 3 months after the first injection. Peripheral blood inflammatory indices were calculated, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet (PLT)-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and C-reactive protein (CRP). Statistical analysis was performed to compare the visual and anatomical results and evaluate HRF and SRF in different stages of DME before and after treatment. Results: There were significant differences in systemic inflammatory indices among the four groups, including NLR, PLR, MLR, SII, and CRP (all p < 0.05). The CRP, NLR, PLR, MLR, and SII were significantly higher in the atrophic stage compared to the advanced stage (all p < 0.05). Conversely, the CRP, NLR, PLR, MLR, and SII were significantly lower in the advanced stage compared to the early stage (all p < 0.05). Except for the atrophic stage, BCVA and central retinal thickness (CRT) were significantly improved after treatment in early, advanced and severe stages (all p < 0.05), especially in the severe stage. The decline in the proportion of SRF and HRF ≥20 was the most significant in the advanced stage after anti-VEGF treatment (p < 0.001, p = 0.016), but not in the early and severe stages (all p > 0.05). Conclusion: Systemic inflammatory indices and the decline in the proportion of SRF and HRF ≥20 were closely associated with different stages of DME based on “TCED.” Meanwhile, the “TCED” grading system can predict visual and anatomical prognosis of DME after anti-VEGF treatment, which may be a biomarker for identifying risk stratification and management of DME.
Efficacy and Safety of Cold Snare Polypectomy versus Cold Endoscopic Mucosal Resection for Resecting 3–10 mm Colorectal Polyps: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Wang Shao-Tong , Kong Qing-Zhou , Li Yan-Qing , Ji Rui
Published: January 2024

Introduction: The safety and efficacy of cold snare polypectomy (CSP) compared to those of cold endoscopic mucosal resection (CEMR) have been reported. This meta-analysis compared the efficacy and safety of CEMR and CSP. Methods: PubMed, Embase, Web of Science, and Cochrane Library databases were systematically searched to identify randomized controlled trials comparing the efficacy and safety of CEMR and CSP in removing 3–10 mm polyps. The outcomes assessed included complete resection rate, intraoperative bleeding rate, delayed bleeding rate, perforation, and polyp removal time. The results are reported as risk ratios (RR) and 95% confidence intervals (CIs) derived from a Mantel-Haenszel random-effects model. Results: Seven studies comprising 1,911 polyps were included in the analysis. The complete resection rate of CEMR was comparable to that of CSP (RR: 1.01, 95% CI: 0.99–1.04, p = 0.32). Comparable results were also demonstrated for intraoperative bleeding rate (polyp-based analysis: RR: 1.22, 95% CI: 0.33–4.43, p = 0.77), delayed bleeding rate (polyp-based analysis: RR: 1.34, 95% CI: 0.44–4.15, p = 0.61), and polyp removal time (mean difference: 28.31 s, 95% CI: −21.40–78.02, p = 0.26). No studies reported cases of perforation. Conclusion: CEMR has comparable efficacy and safety to CSP in removing 3–10 mm polyps. Further randomized controlled trials with long-term follow-up are warranted to compare and validate efficacy.
Serum Angiopoietin-2 Levels Predict the Development of Hepatocellular Carcinoma following Hepatitis C Virus Eradication Using Direct-Acting Antiviral Agents
Authors: Suzuki Takanori , Matsuura Kentaro , Nagura Yoshihito , Kawamura Hayato , Fujiwara Kei , Ogawa Shintaro , Nagaoka Katsuya , Iio Etsuko , Watanabe Takehisa , Kataoka Hiromi , Tanaka Yasuhito
Published: January 2024

Introduction: Our previous studies showed that serum angiopoietin-2 (Ang-2) and C-X-C motif chemokine ligand 10 (CXCL10) levels predicted improvement in liver fibrosis following sustained virological response (SVR) of hepatitis C virus (HCV) obtained with administration of with direct-acting antiviral agents (DAAs). These levels were evaluated retrospectively as predictive indicators of hepatocellular carcinoma (HCC) development following SVR. Methods: We enrolled individuals from a historical cohort of 89 chronic HCV patients without history of HCC at baseline and with SVR following DAA therapy and had baseline serum levels of Mac-2 binding protein glycosylation isomer ≥2.0 cut-off index (C.O.I.). Results: Multivariate analyses revealed that only the Ang-2 level at 24 weeks following the end of treatment (EOT24W) was significantly related to HCC development (hazard ratio 2.27; p = 0.003). This result was reproduced in individuals without history of HCC and with advanced liver fibrosis (M2BPGi level ≥3.3 C.O.I. at baseline). Time-dependent receiver operating characteristic curve analyses for the future risk of developing HCC within 5 years of follow-up (5y-HCC) showed the best cut-off Ang-2 level at the EOT24W was 2,780 pg/mL, and significantly stratified the cumulative incidence of HCC (≥2,780 vs. < 2,780 pg/mL, 5y-HCC: 45.5 vs. 8.2%, p < 0.001). Conclusions: At the EOT24W, serum Ang-2 level predicts the likelihood of developing HCC following SVR to DAA therapy.
Invited Mini Review Metabolic Bone Disease of Prematurity: Overview and Practice Recommendations
Authors: Grover Monica , Ashraf Ambika P. , Bowden Sasigarn A. , Calabria Andrew , Diaz-Thomas Alicia , Krishnan Sowmya , Miller Jennifer L. , Robinson Marie-Eve , DiMeglio Linda A.
Published: January 2024

Metabolic bone disease of prematurity (MBDP) is defined by undermineralization of the preterm infant skeleton arising from inadequate prenatal and postnatal calcium (Ca) and phosphate (PO4) accretion. Severe MBDP can be associated with rickets and fractures. Despite advances in neonatal nutrition, MBDP remains prevalent in premature infants due to inadequate mineral accretion ex utero. There also remain significant knowledge gaps regarding best practices for monitoring and treatment of MBDP among neonatologists and pediatric endocrinologists. Preventing and treating MBDP can prevent serious consequences including rickets or pathologic fractures. Postnatal monitoring to facilitate early recognition of MBDP is best done by first-tier laboratory screening by measuring serum Ca, phosphorus, and alkaline phosphatase to identify infants at risk. If these laboratories are abnormal, further studies including assessing parathyroid hormone and/or tubular resorption of PO4 can help differentiate between Ca and PO4 deficiency as primary etiologies to guide appropriate treatment with mineral supplements. Additional research into optimal mineral supplementation for the prevention and treatment of MBDP is needed to improve long-term bone health outcomes and provide a fuller evidence base for future treatment guidelines.
Sizing and analysis of a standalone photovoltaics system for a three-bedroom residence in Nigeria
Authors: Peter Ohanu Chibuike , Nnamdi Egbo Godson , Sutikno Tole
Published: January 2024

The intermittency of electricity supply from conventional sources, increase in fuel prices and constant emission of greenhouse gases by non-renewable energy sources are major challenges faced by energy users. Energy from reneweable sources have advantages over the traditional (non-renewable) sources of energy. This paper presents the sizing and analysis of a standalone photovoltaic (PV) system for a 3-bedroom residence situated at Obollo-Nsukka (6.876°N, 7.403°E, 389 m) in Nigeria. The energy requirements of such a residence are 8.14 kWh/day and analysis have shown that the cost of constructing the PV system is ₦2,838,040 Nigeria naira (NGN). The cost of maintaining such a system within a lifetime of 20 years is between 159,328 NGN/year to 1,895,918 NGN/year. Comparing the levelized cost of energy (LCOE) of enugu electricity distribution company (EEDC) which is 66.5 NGN/kWh to the LCOE of the standalone PV system which is between 102,124 NGN/kWh to 419 NGN/kWh it was found out that the cost of electricity from the PV system is more than that of the conventional grid.
 The PV system provides feasible solution to the intermittency issues of the conventional grid in Nigeria. Hence, this technology only technically viable for residential electrification purposes in Nigeria.
Optimization of speed droop governor operation at the gas turbine cogeneration unit
Authors: Maharmi Benriwati , Cholid Ilham , Syafii Syafii , Harda Arya Engla
Published: January 2024

Variations in customer demand for active power can impact frequency levels, potentially leading to instability within the electrical power system. To uphold system stability, it becomes essential to control the provision of active power to ensure the frequency remains consistent. This research aims to develop a simulation model for optimizing of the operation of the speed droop governor at the gas turbine cogeneration unit. This research used the quantitative method and descriptive statistical analysis techniques. The simulation model was employed as a simulator for operating the speed droop governor for frequency regulation in the electrical system. The gas turbine cogeneration unit 2 operational data of the speed droop values was used to analyze the influence of the generating unit’s response to changes in frequency. The analysis and simulation results revealed the gas turbine cogeneration unit 2 speed droop value of 4%, which was considered ideal for maintaining the stability of the 60 Hz nominal frequency required by customers.
Enhancing hate speech detection in Indonesian using abusive words lexicon
Authors: Wahyu Pamungkas Endang , Purworini Dian , Galih Prasetyo Putri Divi , Akhtar Sohail
Published: January 2024

Hate speech is a major challenge in Indonesia, a diverse country with multiple languages and a dynamic online landscape. This research explores the phenomenon of hate speech and its detection, particularly in language contexts with limited resources. We introduce a new abusive words lexicon, created by collecting words from various sources, adapted for Indonesian, Javanese and Sundanese. Our study investigates the practical implementation of this lexicon. We conducted extensive experiments using different datasets and machine learning models, aiming to improve hate speech detection. The results consistently show a positive impact of the lexicon, which significantly improves detection, especially in languages with fewer resources. But this research paves the way for further exploration. The lexicon can be expanded, broadening its scope. Additionally, we suggest investigating more sophisticated models, such as transformerbased models, to more effectively detect hate speech. In a world where hate speech is a growing problem, our research provides valuable insights and tools to combat it effectively in Indonesia and other countries.
High-capacity steganography through audio fusion and fission
Authors: Mangikuppe Venkateshaiah Namitha , Govinakovi Rudrappa Manjula
Published: January 2024

Information security is required for two reasons, either to conceal the information completely or to prevent the misuse of the information by adding watermarks or metadata. Audio steganography uses audio signals to hide secret information. In the proposed audio steganography technique, cover audio files and secret audio files are transformed from time domain to wavelet domain using discrete wavelet transform, the secret audio file is transformed in two levels, leading to secure and high-capacity data hiding. 1% of the 2-level compressed secret is fused to 99% of the 1-level compressed cover. “Peak signal to noise ratio and mean squared error, Pearson’s correlation coefficient, spearman’s correlation coefficient, perceptual evaluation of speech quality and short-time objective intelligibility” are considered to assess the similarity of cover audio and stego audio and similarity of secret audio embedded, and secret audio retrieved. Results show that the stego audio signal is perceptually indistinguishable from the cover audio signal. The approach also passed the robustness test.
Mathematical models for resolving the nonlinear formula for solar cell
Authors: Rasheed Mohammed , Alshalal Iqbal , Abdula Ashed Arshad , Abdelhadi Sarhan Mohammed , Shawki Jaber Ahmed
Published: January 2024

Accurate representation of a photovoltaic solar cell requires a comprehensive assessment of modeling factors that are unique to the individual device being studied. In the context of the single diode model, it is necessary to ascertain five distinct parameters, namely Rs, Rsh, Iph, Io, and n. In general, analytical or numerical methods may be used to calculate these values. In this paper, two alternative iterative approaches to solving nonlinear problems in solar cells without temperature are described and analyzed. The new iterative approach has several instances that have been quantitatively tested. This novel approach can be seen as a potential option for solving nonlinear equations. Additionally, a comparison between the suggested method, classic chord formula (CCM), and predictor-corrector type reveals that it is better and has the lowest evaluation. This is supported by an examination of accuracy and efficiency (as evaluated by function evaluations) false position method (FPM).
O contrato racial, de Charles Wade Mills
Authors: Antunes Gabriel Silveira de Andrade
Published: January 2024

Resenha de "O contrato racial" de Charles W. Mills.
FSH Is Responsible for Androgen Deprivation Therapy–Associated Atherosclerosis in Mice by Exaggerating Endothelial Inflammation and Monocyte Adhesion
Authors: Wang Qiang , Han Jingli , Liang Zhenhui , Geng Xueyu , Du Yiqing , Zhou Jing , Yao Weijuan , Xu Tao
Published: January 2024

BACKGROUND:

Androgen deprivation therapy (ADT) is the mainstay treatment for advanced prostate cancer. But ADTs with orchiectomy and gonadotropin-releasing hormone (GnRH) agonist are associated with increased risk of cardiovascular diseases, which appears less significant with GnRH antagonist. The difference of follicle-stimulating hormone (FSH) in ADT modalities is hypothesized to be responsible for ADT-associated cardiovascular diseases.

METHODS:

We administered orchiectomy, GnRH agonist, or GnRH antagonist in male
ApoE

−/−

mice fed with Western diet and manipulated FSH levels by testosterone and FSH supplementation or FSH antibody to investigate the role of FSH elevation on atherosclerosis. By combining lipidomics, in vitro study, and intraluminal FSHR (FSH receptor) inhibition, we delineated the effects of FSH on endothelium and monocytes and the underlying mechanisms.

RESULTS:

Orchiectomy and GnRH agonist, but not GnRH antagonist, induced long- or short-term FSH elevation and significantly accelerated atherogenesis. In orchiectomized and testosterone-supplemented mice, FSH exposure increased atherosclerosis. In GnRH agonist–treated mice, blocking of short FSH surge by anti-FSHβ antibody greatly alleviated endothelial inflammation and delayed atherogenesis. In GnRH antagonist–treated mice, FSH supplementation aggravated atherogenesis. Mechanistically, FSH, synergizing with TNF-α (tumor necrosis factor alpha), exacerbated endothelial inflammation by elevating VCAM-1 (vascular cell adhesion protein 1) expression through the cAMP/PKA (protein kinase A)/CREB (cAMP response element-binding protein)/c-Jun and PI3K (phosphatidylinositol 3 kinase)/AKT (protein kinase B)/GSK-3β (glycogen synthase kinase 3 beta)/GATA-6 (GATA-binding protein 6) pathways. In monocytes, FSH upregulated CD29 (cluster of differentiation 29) expression via the PI3K/AKT/GSK-3β/SP1 (specificity protein 1) pathway and promoted monocyte-endothelial adhesion both in vitro and in vivo. Importantly, FSHR knockdown by shRNA in endothelium of carotid arteries markedly reduced GnRH agonist–induced endothelial inflammation and atherosclerosis in mice.

CONCLUSIONS:

FSH is responsible for ADT-associated atherosclerosis by exaggerating endothelial inflammation and promoting monocyte-endothelial adhesion.
Remote Midlatitude Control of Rainfall Onset at the Southern African Tropical Edge
Authors: Knight Charles , Washington Richard
Published: January 2024

Rainfall over the southern African tropical boundary is highly variable, particularly around the onset of the summer rains. However, understanding of the causes of variability in onset timing is poor. A lack of observational data in the region is compounded by the complexity of climate dynamics and variability at the interface of the tropics and the midlatitudes. The key to onset over the region is the Congo air boundary (CAB), a distinguishing circulation feature present in September and declining in frequency until November. The CAB is crucial to early season rainfall; precipitation is broadly inhibited when the CAB is present, while its breakdown allows large-scale rainfall and onset over central southern Africa. This work identifies a remote midlatitude influence on the timing of CAB breakdown using the high-resolution reanalysis dataset ERA5. Propagating and (upstream) breaking low-wavenumber Rossby waves in the Southern Hemisphere westerly jet are shown to be related to >70% of breakdown events. Breakdown is forced by 1) the replacement of subsidence over eastern southern Africa with synoptically forced ascent and 2) wind field modification that leads to positive 850-hPa continental convergence anomalies and enhanced moisture advection from the Congo basin and Indian Ocean. Upper-level anticyclonic vorticity tendency induced by enhanced convection slows Rossby wave propagation aloft, contributing to wave breaking and the persistence of conditions favorable to convection. The identification of this midlatitude influence on CAB breakdown reveals new potential sources of predictability for onset and demonstrates the significant equatorward extent of midlatitude influences to the tropical edge.

Significance Statement

This study aims to improve our understanding of the causes of variability in the start date of the summer rainy season in central southern Africa. The research reveals that certain upper-level waves in the Southern Hemisphere westerly jet are associated with patterns of weather that force a large-scale transition from dry pre-onset conditions to widespread rainfall in a time scale of 2–5 days, and that these waves account for a large proportion of such transitions. This finding is of interest to subseasonal weather forecasters and may help to improve the long-range forecasting of onset date.
Postoperative Gastrointestinal Dysfunction After Neuromuscular Blockade Reversal With Sugammadex Versus Cholinesterase Inhibitors in Patients Undergoing Gastrointestinal Surgery: A Systematic Review and Meta-Analysis
Authors: Sharma Sahil , McKechnie Tyler , Talwar Gaurav , Patel Janhavi , Heimann Luke , Doumouras Aristithes , Hong Dennis , Eskicioglu Cagla
Published: January 2024

Background

Postoperative gastrointestinal dysfunction (POGD) commonly occurs following gastrointestinal (GI) surgery and is associated with specific anesthetic agents. Cholinesterase inhibitors employed for reversing neuromuscular blockade have been implicated in development of POGD. Sugammadex, a novel reversal agent, is linked with reduced POGD. However, there is a lack of comprehensive comparative review between these agents regarding their impact on POGD following GI surgery. This study aims to systematically review the effects of sugammadex on POGD compared to cholinesterase inhibitors following GI surgery.

Methods

MEDLINE, EMBASE, and CENTRAL were searched as of July 2022 to identify articles comparing sugammadex with cholinesterase inhibitors in patients undergoing gastrointestinal surgery, specifically in relation to POGD. Secondary endpoints included length of hospital stay, readmission rates, pulmonary complications, and postoperative morbidity.

Results

From 198 citations, 2 randomized controlled trials (RCTs) and 3 retrospective cohorts with 717 patients receiving sugammadex and 812 patients receiving cholinesterase inhibitors were included. Significantly lower rates of prolonged postoperative ileus (OR .44, 95% CI .25-.77, P < .05, I2 = 56%, low certainty evidence) was observed with sugammadex. No significant difference in any other outcome was observed. Narrative review of readmission data demonstrated no significant difference.

Conclusion

The use of sugammadex following gastrointestinal surgery is associated with significantly lower rates of prolonged postoperative ileus compared to cholinesterase inhibitors. However, these do not translate into a significant reduction in length of stay, morbidity, or postoperative nausea and vomiting. Results are limited by the numer of studies included and missing data, more robust RCTs are needed before recommendations can be made.
Role of Governance Quality in Remittances-poverty Relationship: New Insights from Transition Economies
Authors: Shah Imtiyaz Ahmad , Wani Ghowhar Ahmad
Published: January 2024

This study examines the moderating role of institutional quality on a remittance-poverty relationship using a panel of 16 transition economies for 2002–2020. The study used pooled mean group/autoregressive distributed lag estimation with unit root and cointegration tests. The poverty is proxied by household consumption expenditure. After establishing cointegration, remittances and institutional quality index were found to positively affect poverty alleviation in the long run. The interactive term showed that remittances and institutional quality complemented the remittance-poverty relationship. In addition, a unidirectional causal relationship existed from remittance to poverty alleviation and institutional quality to poverty. Further, bidirectional causality existed between remittances and institutional quality, which confirms their complementary nature in the remittance-poverty relationship. Lastly, policy prescriptions are provided in the conclusion of the article.

JEL Codes: F22, F24, J61
Hepatitis B Care Continuum Models—Data to Inform Public Health Action
Authors: Spradling Philip R. , Bocour Angelica , Kuncio Danica E. , Ly Kathleen N. , Harris Aaron M. , Thompson Nicola D.
Published: January 2024

The application of a care continuum model (CCM) can identify gaps in diagnosis, care, and treatment of populations with a common condition, but challenges are inherent in developing a CCM for chronic hepatitis B. In contrast with treatment for HIV or hepatitis C, treatment is not indicated for all people with chronic hepatitis B, clinical endpoints are not clear for those receiving treatment, and those for whom treatment is not indicated remain at risk for complications. This topical review examines the data elements necessary to develop and apply chronic hepatitis B CCMs at the jurisdictional health department level. We conducted a nonsystematic review of US-based publications in Ovid MEDLINE (1946–present), Ovid Embase (1974–present), and Scopus (not date limited) databases, which yielded 724 publications for review. Jurisdictional health departments, if properly supported, could develop locale-specific focused CCMs using person-level chronic hepatitis B registries, updated longitudinally using electronic laboratory reporting data and case reporting data. These CCMs could be applied to identify disparities and improve rates in testing and access to care and treatment, which are necessary to reduce liver disease and chronic hepatitis B mortality. Investments in public health surveillance infrastructure, including substantial enhancements in electronic laboratory reporting and case reporting and the use of supplementary data sources, could enable jurisdictional health departments to develop modified CCMs for chronic hepatitis B that focus, at least initially, on “early” CCM steps, which emphasize optimization of hepatitis B diagnosis, linkage to care, and ongoing clinical follow-up of diagnosed people, all of which can lead to improved outcomes.
The Concept of Sacramental Goods: Addressing Veblen's Critique of Liturgy
Authors: Blosser Andrew
Published: January 2024

Liturgy invites participants to partake in spiritual goods that are also economic commodities. This article explores the liturgical significance of these commodities through the lens of Veblenian thought. Thorstein Veblen argues that consumption of positional or inherently limited goods signifies predatory status, and that liturgy similarly uses such resources to depict God as a predator. Addressing Veblen's analysis of liturgy, Paul's explanation of the eucharist in 1 Corinthians 11 suggests that the goods of liturgy are the antitheses of positional goods, insofar as they attain their highest goodness when shared equitably. Such “sacramental goods” provide a means for viewing divine participation not only in the liturgy, but also in the broader economy. Selected implications follow, including a need to orient the aesthetics of the liturgy toward shared rather than limited goodness, and cautious employment of consumerist emblems in liturgical settings.
Associated Factors of Suicidal Behavior Among Persons with Physical Disability: A Systematic Review
Authors: Kumar Suneel , Lata Swaran , Verma Saroj , Anupriya
Published: January 2024

Background:

Suicide is common among persons with physical disabilities as they face several physical, social, psychological, and economic problems. They are at risk for suicidal thoughts, behaviors, and death by suicide. We aimed to systematically review empirically published articles and identify the associated factors of suicidal ideation and suicide attempts in persons with physical disabilities.

Methods:

A systematic search was carried out on the literature published from January 1, 2000 to January 19, 2023 in PubMed, Cochrane, Web of Science, Google Scholar, Shodh Ganga, and so on. All the synonyms of keywords or MeSH terms for suicidal ideation, suicide attempt, and physical disability were used. Two hundred thirty-six articles were found, and after following inclusion and exclusion criteria, 12 remained.

Result:

The associated factors of suicidal behavior were disability status (11/12 studies), burdensomeness (8/12 studies), felt stigma (4/12 studies), depressive symptoms (6/12 studies), loneliness (2/12 studies), lack of social and emotional connectedness (2/12 studies), long-term physical or mental disability (2/12 studies), congenital disability (1/12 studies), and aggression (1/12 studies).

Conclusion:

Timely, evidence-based, low-cost interventions can provide great assistance and address the specific needs of this vulnerable population as they have higher risk for suicidal behavior.
Adverse Childhood Experiences, Coping and Resilience in Persons with Alcohol Use Disorder and Their Non-drinking Siblings in High-density Families: A Case-control Study
Authors: Sreenivasulu M.  , Prathyusha Vasuki , Ezhumalai Sinu , Narayanan Gitanjali , Murthy Pratima
Published: January 2024

Background:

Adverse childhood experiences (ACEs) increase the odds of alcohol use disorder (AUD).

Aim:

To study the ACEs, coping, and resilience in persons with AUD and their non-drinking siblings from high-density families.

Methods:

The study used a case-control study design. Using purposive sampling, 135 participants were selected; the sample consists of persons with AUD ( n = 45), non-drinking siblings ( n = 45), and healthy controls ( n = 45), selected from out-patient and in-patient services from a government-run de-addiction centre in Bengaluru. Individuals were administered an ACEs questionnaire, Brief-COPE, and Connor-Davison Resilience scale. Descriptive statistics, Friedman’s test, and Bonferroni’s post-hoc test, Binary Logistic Regression were used for analysis.

Results:

ACEs, coping, and resilience significantly differ across the three groups. Persons with AUD and their non-drinking siblings are comparable in terms of ACEs and having dysfunctional family members. Non-drinking siblings and healthy controls have similar coping and resilience. None of the healthy controls had dysfunctional family members.

Conclusion:

ACEs are more prevalent and more frequent in persons with AUD. Individuals with AUD showed higher avoidant coping and lower resilience than their non-drinking siblings and healthy controls. Early identification of ACEs and interventions to build resilience and coping strategies could prevent individuals from developing AUD in high-density families.
Third generation of laser (>1900) for endovenous thermoablation (EVLA) of varicose veins: A systematic review and meta-analysis
Authors: Palombi Luca , Morelli Monica , Bruzzese Dario , Quarto Gennaro
Published: January 2024

Objectives

Third generation lasers with longer wavelengths (>1900 nm) have been introduced, in recent years, for the treatment of varicose veins. The possible advantage of the new generation lasers is that they allow complete damage to the vein wall using a lower Power in Watts (W: J/sec) and a lower linear energy density (LEED: J/cm). The aim of this work is to evaluate the results present in the literature regarding efficacy and safeness of the new generation lasers for the treatment of varicose veins.

Methods

Published articles were searched on PubMed database and on Cochrane Library, entering the keywords “1940 nm or 1920 nm laser AND varicose veins laser thermoablation (EVLA).” The primary endpoint of the study was to value rate of occlusion and adverse events at the short term follow-up. The search yielded a total of 14 studies. In the end, only six studies were judge eligibility.

Results

The studies were heterogenous in their documentation, EVLA, duplex ultrasound protocol and result reporting. A total of 540 limbs of 377 patients were treated with endovenous laser ablation (EVLA) with laser 1920–1940 nm. The treated veins had a mean diameter of 0.74 ± 0.17 cm and a mean length of 27.87 ± 20.63 cm. The pooled estimates of immediate occlusion rate was of 99.8% (95% CI: 97.9% to 100.0) with high heterogeneity (I2 = 60%; 95% PI: 89.7% to 100%), while at short-term follow-up was of 98.2% (95% CI: 94.0% to 100.0%) with higher heterogeneity (I2:79%; 95% PI: 77.1% to 100.0%). EHIT occurred in 7 cases (pooled estimate: 0.7%). The other adverse events rate reported were 1% of hyperpigmentation, 2.8% of neurological complications, 0.6% thrombophlebitis and 1.9% of bruising/hematoma. The pooled mean estimates of LEED was equal to 38.2 J/cm (95% CI: 26.3 to 50.1 J/cm) although with a very large heterogeneity (I2 = 100%).

Conclusions

The overall success rate of EVLA was high. The analysis of these studies suggests that using lower parameters (Power and linear administered energy) may have no effect on the treatment success rate. Short-term results demonstrate comparable occlusion rates respect the second-generation lasers. Instead, data suggest a low complication rates. Short-term results demonstrate comparable complications rates respect the second-generation lasers (1300-1470 nm). Randomized studies with longer follow-up are required to evaluate the EVLA 1900 nm procedure further.
Atrioventricular block in patients with hyperthyroidism: a narrative review
Authors: Ata Fateen
Published: January 2024

Atrioventricular block (AVB) is a rare cardiac manifestation of hyperthyroidism (HTH). The scientific literature contains multiple reports of AVB in patients with HTH, ranging from subclinical to overt HTH and even thyroid storm. However, much remains unknown about the true prevalence, clinical course, optimal management, and outcomes of AVB in patients with HTH. Such patients are possibly overtreated with pacemakers because of a lack of understanding that AVB might be secondary to the hyperthyroid state and thus reversible. This narrative review discusses the pathophysiology of AVB in patients with HTH in the context of the available evidence.
Examining the importance of local and global patterns for familiarity detection in soccer action sequences
Authors: Hope Ed R. , Patel Keval , Feist James , Runswick Oliver R. , North Jamie S.
Published: January 2024

Pattern recognition is a defining characteristic of expertise across multiple domains. Given the dynamic interactions at local and global levels, team sports can provide a vehicle for investigating skilled pattern recognition. The aims of this study were to investigate whether global patterns could be recognised on the basis of localised relational information and if relations between certain display features were more important than others for successful pattern recognition. Elite ( n = 20), skilled ( n = 34) and less-skilled ( n = 37) soccer players completed three recognition paradigms of stimuli presented in point-light format across three counterbalanced conditions: ‘whole-part’; ‘part-whole’; and ‘whole-whole’. ‘Whole’ clips represented a 11 vs. 11 soccer match and ‘part’ clips presented the same passages of play with only two central attacking players or two peripheral players shown. Elite players recognised significantly more accurately than the skilled and less-skilled groups. Participants were significantly more accurate in the ‘whole-whole’ condition compared to others, and recognised stimuli featuring the two central attacking players significantly more accurately than those featuring peripheral players. Findings provide evidence that elite players can encode localised relations and then extrapolate this information to recognise more global macro patterns.
Disappointment’s Magic: Negative Emotions, Transitional Justice and Resistance
Authors: Mrovlje Maša
Published: January 2024

This article explores how an existential account of emotions can enrich debates about negative emotions in transitional justice and peacebuilding scholarship. A growing literature has examined the challenge that the ex-resisters’ negative emotions, including disappointment, pose to the creation of sustainable peace in post-conflict societies. It has however not sufficiently accounted for disappointment’s potentially productive political value. The paper fills this gap by examining how the ex-resisters’ disappointment affects their capacity for political action against the remainders of past violence and oppression, with a specific focus on the South African context. I draw on Jean-Paul Sartre’s existential account of the emotions’ ‘magic’ as a way of coping with the complexities of political action arising from our situated condition. I put Sartre’s account in conversation with Nadine Gordimer’s novel No Time Like the Present and experiences of disappointment among South African ex-resisters to show how disappointment can lead ex-resisters to different ways of confronting the complexity of political engagement in the wake of the incomplete transition. This dialogue reveals disappointment as a powerful source of resistance against the persistence of injustice, while also disclosing significant constraints upon political engagement in conditions of systemic violence.

Le magique de la déception : Émotions négatives, justice transitionnelle et résistance
Incidence of and Risk Factors for Medial Meniscal Lesions at the Time of ACL Reconstruction: An Analysis of 4697 Knees From the SANTI Study Group Database
Authors: Giurazza Giancarlo , Saithna Adnan , An Jae-Sung , Lahsika Mohammed , Campos Joao Pedro , Vieira Thais Dutra , Guier Christian A. , Sonnery-Cottet Bertrand
Published: January 2024

Background:

Medial meniscal (MM) lesions (MMLs) are a common finding at the time of anterior cruciate ligament reconstruction (ACLR). It is recognized that evaluation of the posteromedial compartment reduces the rate of missed MML diagnoses.

Purpose:

To determine the incidence of MMLs in patients undergoing ACLR, when using a standardized arthroscopic approach that included posteromedial compartment evaluation, as well as to determine how the incidence of MMLs changed with increasing time intervals between injury and surgery, and to investigate what risk factors were associated with their presence.

Study Design:

Case series; Level of evidence, 4.

Methods:

A retrospective analysis of prospectively collected data was performed. All patients who underwent primary ACLR between January 2013 and March 2023 were considered for study eligibility. The epidemiology was defined by categorizing and reporting the incidence and categorizing the spectrum of MM tear types. Risk factors associated with MMLs were analyzed using a logistic regression model.

Results:

MMLs were identified in 1851 (39.4%) of 4697 consecutive patients undergoing ACLR. The overall incidence of MMLs was 33.1% for the period of 0 to 3 months, 38.7% for the period of 3 to 12 months, and 59.6% for the period of >12 months. The overall incidence of MMLs increased with longer durations of time between injury and surgery, along with significant increases in complex, bucket-handle, ramp, and/or flap lesions. The largest increase in incidence of MMLs was observed for complex MM tear patterns. Risk factors associated with MMLs included time between injury and surgery >3 months (odds ratio [OR], 1.320; 95% CI, 1.155-1.509; P < .0001) and >12 months (OR, 3.052; 95% CI, 2.553-3.649; P < .0001), male sex (OR, 1.501; 95% CI, 1.304-1.729; P < .0001), body mass index (BMI) ≥25 (OR, 1.193; 95% CI, 1.046-1.362; P = .0088), and lateral meniscal lesion (OR, 1.737; 95% CI, 1.519-1.986; P < .0001).

Conclusion:

Overall, MMLs were identified in 39.4% of 4697 patients undergoing ACLR when posteromedial compartment evaluation was performed in addition to standard anterior viewing. The incidence of MMLs and the complexity of tear types increased significantly with increasing time intervals between the index injury and ACLR. Secondary risk factors associated with an increased incidence of medial meniscal tears include male sex, increased BMI, and lateral meniscal lesions.
Civil war and state support for conventional arms control
Authors: Risse Tobias
Published: January 2024

Conventional arms control imposes costs and benefits on states in civil wars: it restricts their own armament and that of rebel groups. I argue that the benefits outweigh the costs because states design conventional arms control measures that primarily curb rebels’ armament. I investigate these arguments through regression analyses of United Nations General Assembly (UNGA) voting records and a content analysis of UNGA speeches. While I find a positive relationship between civil wars and support for conventional arms control in the aggregate, I also show that states in civil wars consider both the benefits and the costs of arms control.
Effect of classroom-based physical activity on teaching quality of systemic lupus erythematosus for medical undergraduates
Authors: Chen Yong , He Mang , Tian Shidan , Jiang Yan , Zhang Yongqiao , Lin Yupei , Xing Zhouxiong , Nandakumar Kutty Selva , Tian Mei
Published: January 2024

Objective

To explore the influence of classroom-based physical activity (CB-PA) on the teaching quality of systemic lupus erythematosus (SLE) for medical undergraduates.

Methods

Students from 8 classes participating in the clinical medicine program of the affiliated hospital of Zunyi Medical University were divided into two groups. Four classes received regular teaching on the SLE chapter as the control group, and the other four received CB-PA intervention as the experimental group. After class, the basic ability (diagnostics and pharmacology scores in sophomore year) and teaching quality scores were collected and compared using a questionnaire. The performance of the 2 groups to the SLE review questions was compared.

Results

The scores of learning interest, the degree of satisfaction with the courses, and the level of mastering the teaching contents in the experimental group were significantly higher than those in the control group. The evaluation of the teacher’s teaching level increased considerably. The experimental group’s performance was also better than the control group’s (the assessment performance was adjusted with the basic ability).

Conclusion

CB-PA in teaching SLE improves students’ interest in learning, teaching satisfaction, and mastery of knowledge and may ultimately enhance their assessment results.
Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm
Authors: Chen Cheng-Fong , Chen Yi-Chung , Fu Yu-Show , Tsai Shang-Wen , Wu Po-Kuei , Chen Chao-Ming , Chen Wei-Ming , Wu Hung-Ta Hondar , Lee Chia-Hsin , Chang Chao-Liang , Lin Po-Cheng , Kao Yong-Cheng , Chen Chun-Hung , Chuang Ming-Hsi
Published: January 2024

The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. The 3 + 3 phase I study was designed with two dose-escalation cohorts: low dose (6.7 × 106 GXCPC1, N = 5) and high dose (4 × 107 GXCPC1, N = 6). The primary endpoint was safety, which was evaluated by recording adverse events throughout the trial; the secondary endpoints included total, pain, stiffness, and function subscales of the Western Ontario and McMaster Universities Arthritis Index (WOMAC), Visual Analogue Scale (VAS) for pain, and 12-Item Short Form (SF-12) health survey questionnaire. The GXCPC1 treatment was found to be safe after 1 year of follow-up with no treatment-related severe adverse events observed. When compared to baseline, subjects in both the low- and high-dose cohorts demonstrated improving trends in pain and knee function after receiving GXCPC1 treatment. Generally, the net change in pain (95% confidence interval (CI) = −7.773 to −2.561t at 12 weeks compared to baseline) and knee function (95% CI = −24.297 to −10.036t at 12 weeks compared to baseline) was better in subjects receiving high-dose GXCPC1. Although this study included a limited number of subjects without a placebo arm, it showed that the intra-articular injection of ADSCs was safe and well-tolerated in subjects with therapeutic alternatives to treat knee OA. However, a larger scale study with an appropriate control would be necessary for clinical efficacy in the following study.
Perso-Sanskrit Narratives of the Mughal’s Tasḵẖīr-i-kashmir: Phased Opening, Ecology and Literary Strategies
Authors: Hassan Shakir ul
Published: January 2024

This study explores the Mughal conquest of Kashmir (tasḵẖīr-i-kashmīr) through the region’s phased openings rather than a singular watershed event signalling either a climactic loss of independence or ushering in a golden age. Before 1585–89, there were two decades of patronage, diplomacy, and a steady breaching of the valley’s defences. When Mughal dominion was established, sections of the local aristocracy figured prominently as part of the new dispensation of power, while others continued to offer resistance. An analysis of imperial and local Perso-Sanskrit narratives of the conquest yields insight into how Kashmir was incorporated into the Mughal empire. This micro-historical process is the most valorised of historical transitions within the early Mughal literary discourse, it was highly represented as moment of glory and grand vehicle for rhetoric of diplomatic propaganda. This study largely demonstrates pre-modern power elites’ graded political loyalties, multi-laterality of socio-historical and ecological processes that facilitated the Mughal kingdom-seizing in Kashmir. Simultaneously moving beyond the traditional binary of ‘conquest’ vs ‘resistance’ conceptualisation and political abuse of the local narratives, it navigates the analytical efficacy and social logic of five primary narrative constructions of the Conquest produced by Mughal political elites and regional counter-elites in the terminal decade of sixteenth and early decades of the seventeenth century, namely, Akbarnāmā, Insha’ Abū’l Faẓl, Śukha-rājataraṅgiṇī, Bāhāristān-i-Sháhi and Taʼrīḵẖ-i-Kashmir.
“Nature Environments Without Actually Being There”: Virtual Recreation Experiences and Real-World Intentions
Authors: Williams Nathan
Published: January 2024

Background: Despite access to nature-based recreation, many college students do not take advantage of these experiences to improve their mental and physical health. Virtual reality experiences provide a potential pathway to motivate this population to recreate outdoors, but research is needed to determine whether virtual recreation can lead to real-world intent to recreate. Purpose: This study investigated whether virtual reality experiences influence student motivation for nature-based recreation, as measured with the intention and self-efficacy to spend time in nature scales. Methodology/Approach: As part of an introductory parks, recreation, and tourism class, students explored nature through virtual reality. The study incorporated a mixed methods design using pre- and post-experience surveys, interviews with participants, and document analysis of student assignment submissions over Instagram. Findings/Conclusions: Preliminary findings suggest that virtual reality can approximate real-world nature environments and provide a potential pathway for this population to access real-world outdoor recreation opportunities. Implications: In situations where real-world field experiences are not possible, educators and practitioners can use the findings of this study to assess whether a virtual recreation experience is appropriate for their audience. While these experiences do not substitute real-world nature, they may be part of a participant’s pathway to recreate outdoors.