bluuebunny/crossref_metadata_2025 huggingface dataset:
Petrography, Palynology, and Organic Geochemistry of Neogene Paralic Coal, Mukah,Sarawak, Malaysia: Implications For Paleomires, and Peat-Forming Conditions
Authors: Abidin Nor Syazwani Zainal , Mustapha Khairul Azlan , Abdullah Wan Hasiah , Konjing Zainey
Published: October 2021

The eight coal seams of Neogene paralic coals from Mukah coalfield, Sarawak, Malaysia, were investigated using petrographical, palynological, and organic geochemical analyses to describe coal-forming vegetation, conditions during peat development and precursor mires, and their associations in a sequence-stratigraphic context. The petrographic data of the coals implies the existence of oxygen-deficient and water-saturated conditions in the precursor mires. The condition of low mire oxidation was followed by biomass loss from the mires. The Mukah coals are suggested to be deposited in freshwater peat swamps, and the rich preservation of angiosperm pollens indicates that the organic matter in dense and lowland forest vegetation was mostly terrigenous. The overwhelming presence of Casuarina and Calamus types, suggesting the paleomires were closely linked to Kerapah/Kerangas peat forest and marginally bordered by rattan and supported by the biomarker data. Rheotrophic–ombrotrophic mires were temporarily formed because of water table fluctuations, which strongly depend on ever-wet climate changes and syn-depositional tectonic during the Neogene, resulting in balanced to high peat accumulation and preservation. A maximum thickness of 35m of peat deposits that formed between 10,000 and 175,000 years ago is suggested. The coals are proposed to be influenced by transgressive to initial highstand cycles within the paralic setting.
Key Role of Mitochondrial Mutation Leu107Ser (COX1) in Deltamethrin Resistance in Salmon Lice (Lepeophtheirus Salmonis)
Authors: Tschesche Claudia , Bekaert Michaël , Bassett David I. , Boyd Sally , Bron James E. , Sturm Armin
Published: October 2021

Deltamethrin (DTM) is used to treat Atlantic salmon (Salmon salar) against salmon lice (Lepeophtheirus salmonis) infestations. However, development of DTM resistance has been reported from North Atlantic L. salmonis populations, in which resistance is associated with mitochondrial (mtDNA) mutations. This study investigated the relationship between DTM resistance and mtDNA single nucleotide polymorphisms (SNPs). A total of 188 L. salmonis collected from Scottish aquaculture sites were assessed using DTM bioassays and genotyped at 18 SNP loci. Genotyping further included archived parasites of known DTM susceptibility status. The results identified eleven mtDNA haplotypes, three of which were associated with DTM resistance. Phylogenetic analyses of haplotypes suggested multiple origins of DTM resistance. L. salmonis laboratory strains IoA-00 and IoA-10 showed similarly high levels (~100-fold) of DTM resistance in bioassays. Both strains differed strongly in mtDNA haplotype, but shared the missense mutation Leu107Ser in the mitochondrial gene cytochrome c oxidase subunit 1 (COX1), which was detected in all further DTM resistant L. salmonis isolates assessed. In crossing experiments with a DTM-susceptible strains, maternal inheritance of DTM resistance is apparent with both IoA-10 (this study) and IoA-02 (earlier reports). We conclude that Leu107Ser (COX1) is a main genetic determinant of DTM resistance in L. salmonis.
MIGRATION OF SCIENTISTS IN THE GROWTH OF THE POTENTIAL OF SCIENTIFIC AND EDUCATIONAL SPACE: LESSONS OF EU AND US COUNTRIES
Authors: Polishchuk Ye. , Nagorna O.
Published: October 2021

Such a phenomenon as the migration of scientists can be considered from different points of view. In particular, some scholars share the view that this is a negative aspect in the development of the scientific and educational space of a particular country, while others believe that with the right migration policy, it can greatly strengthen the competitiveness of the country that scientists leave. The aim of the article is to highlight the latest trends in the policies of various EU and US countries, as well as to develop practical recommendations for the implementation of some aspects of Ukraine's migration policy for such a category as scientists. The main research method is a comparative analysis, which allows to clearly identify the advantages and disadvantages of each migration policy of each country. The migration of scientists can be used by a single university to establish strong communication with those universities that accept immigrant scientists, which will only be useful for building their future relationships. The article also identifies the advantages and disadvantages of such a phenomenon as the migration of scientists. The definition of virtual migration is given and its main forms and directions are determined. The article considers and compares the migration of scientists and the migration of engineers on the example of Great Britain. It is proved that foreign scientists often occupy positions in those fields where domestic specialists for various reasons do not want to work. The experience of Lithuania has proved the possibility of successful cooperation, which goes beyond the individual level to the level of cooperation with foreign universities. And this was facilitated by the tendency to digitalize various processes. It has been determined that scientists belong to one of the most traveling professions, and many scientists cross borders in search of opportunities. Their state of affairs is explained primarily by an adventurous spirit and a thirst for constant search, which is developed in scientists. Moreover, it is simply the nature of the work - usually, depending on the topic, only a dozen scientists can deeply understand a narrow study - not to mention to help advance it, so scientists are forced to migrate around the world. Upon completion, a number of measures are proposed to increase the potential for cooperation between scientists of Ukrainian origin around the world.
The relationship between brand associations and fan behaviours for football teams
Authors: Eskiler Ersin , Altunisik Remzi , Sarikaya Nilgun
Published: October 2021

The intense competition in the sports sector has caused changes in the sports marketing perception of team management. Club managements aim to develop brand relationships, strengthen fan loyalty and manage fan behaviors to establish an emotional bond between club brands and fans for gaining competitive advantage. In this context, the current study aimed to assess the relationships between brand relationships, fan loyalty, and fan behavior in football teams. The survey sample is 503 (293 male, 210 female) respondents. Data were collected from Besiktas Gymnastics Club, Fenerbahce Sports Club, and Galatasaray Sports Club team supporters by face-to-face survey method. The structural equation model was used in the research hypothesis testing. The findings identified no statistically significant effect of the attributes and benefits, defined as team brand associations facets, on fan behaviors. Brand associations had a significant influence on the attitudinal and behavioral loyalty of supporters. Besides, behavioral loyalty was an important determinant of fan behaviors. The results indicated that approximately 68% of the variance of attitudinal loyalty could be explained by the attributes and benefits of brand associations’ facets (R2=.677). Furthermore, facets of the brand associations accounted for approximately 66% of behavioral loyalty variance (R2=.659). Both brand associations (attributes and benefits) and fan loyalty (attitudinal and behavior loyalty) facets explained approximately 32% of the variance in fan behavior (R2=.317). Consequently, it is important to create strong and competitive brand associations in football teams, independent of sporting achievement, create positive fan behaviors, and support these behaviors. The research results could be useful for sports managers/marketers and theorists to explain and interpret fan behaviors.
Innovations in human resources management: impact on economic growth
Authors: Danova Monika , Kravcakova Vozarova Ivana , Sira Elena
Published: October 2021

In recent years, human capital has become increasingly emphasized as a factor of economic growth. Managing human capital could stimulate the whole economy to better performance in competitiveness. Although these indicators include several variables, there is no precise determination of which indicator mostly affects the country's economic growth. This paper summarizes the knowledge and approaches of several authors in the field of economic growth, knowledge economy, competitiveness, innovations and individual elements affecting these areas. It outlines the findings and provides some insight into the impact of individual factors on economic growth across recent studies. The main goal is to obtain information about the impact of education, its support, and its influence on economic performance on the example of empirical data documenting the qualitative parameters of the workforce. The use of selected indicators indicated their impact on the change in economic performance. The partial objective is to identify an indicator or set of indicators that could express the impact of human capital on economic growth. The study involved research methods such as analyzes, statistical methods such as correlation and p-value, and prediction for the next period based on past developments. The research object is the V4 countries – the Czech Republic, Slovakia, Hungary, and Poland. The findings pointed to the strong impact of the analyzed factors on economic growth. Besides, they showed which of the known ways to increase the efficiency of the labor factor were actually or little used in the sample countries. Undoubtedly, there is also an indicative and interesting comparison within a group or with other economies at a comparable economic and social development level. Finally, improvements to the current situation were proposed. The systematization of literary sources and approaches to economic growth helps identify possible proposals for improving competitiveness in the future, using innovative approaches.
Closing techniques for selling software innovations
Authors: Kozludzhova Katerina
Published: October 2021

The paper aims to generate and establish an understanding of effective closing techniques for selling innovative products. Closing a sale is important because this is the stage of the sales process where companies convince their customers to commit to their offer. Using the right closing technique has a huge impact on the outcome of the deal. The paper outlines the importance of the sales closing techniques for the accomplishment of the innovation commercialization process. The literature review and the conducted research study emphasized the sales process as a key factor for the successful commercialization of innovations in the software industry. Software companies feel confident in their ability to develop innovations but not in their ability to sell them. The research employed a descriptive research design. It used a quantitative method for data collection, which was the survey method. The research object is product managers and owners of software companies in Bulgaria. The conduction of the survey used the probability sampling design. Apart from the primary research, secondary data was also examined. The literature review was another research method for data collection used in the research study. The paper presents the results of a literature review and an empirical analysis, which confirm the importance of the sales process in the software industry when innovative products are concerned. Using the right selling techniques, companies develop a successful sales process for the innovative products they create. These findings resulted in searching and presenting effective selling techniques that salespeople in the software industry can use when selling innovations. Software companies recognize that the sales process requires certain knowledge of sales and the last stage of the sale process (the close stage). The research paper provides deeper meaning and understanding of the concept of selling and establishes the importance of using different closing techniques to persuade the customer to buy innovative products. Key salesperson's abilities and skills were also discussed in the paper. Based on the literature analysis and the conducted research study, the author summarized main and supporting closing techniques that could be useful for sales representatives in the software industry to sell more innovative products, build long-term relationships, and win trusted customers. The author outlined some main knowledge and abilities required for selling innovative products in the software industry.
Regression models of adsorbing nickel (II) ions by carbon sorbents
Authors: Irinchinova N. V. , Dudarev V. I. , Filatova E. G. , Aslamova V. S.
Published: October 2021

Abstract: The use of inexpensive materials such as sorbents increases the competitive advantages of removing heavy metal ions, including nickel (II) ions, from aqueous solutions and wastewater. Such materials include active carbons – carbon sorbents. The oxidized carbon sorbent AD-05-2 and its original analogue have been used as the object of this research. The oxidation of carbon sorbent AD-05-2 was conducted using a solution of nitric acid and urea following a conventional method. Oxidation resulted in improvement of the textural characteristics of the carbon sorbent. The total pore volume increased, including the volume of micropores, which had a positive effect on the sorption properties of the obtained sample. This article studies the adsorption of nickel (II) ions by the oxidized carbon sorbent AD-05-2 and its original analogue. For both models, the total time of establishing adsorptive equilibrium in the system adsorbate–adsorbent was 4 hours, pH = 9,6, and the range of temperatures – 298–338 K. The obtained experimental data on the nickel (II) ion adsorption are processed in the software package Statgraphics Plus. Adsorption isotherms are described using parabolic regression models, which cover 98.86–99.99% of the experimental data. The adsorption of nickel (II) ions increases with temperature, as indicated by a higher value of the first derivative dA/dCp, apparently, due to accelerated external diffusion. A significant steep rise of the isotherms corresponds to the temperature of 338 K, which indicates the diffusion effect on the adsorption process. The estimates of the accuracy of regression models are provided by the mean square σ and absolute Δ errors. Autocorrelation of experimental data is estimated using Durbin – Watson (DW) test. The obtained regression models can be applied for calculating the optimum parameters of nickel (II) ions’ adsorption from aqueous solutions and process stream using the oxidized carbonic sorbent AD-05-2 and its original analog.
Selecting multi-enzyme composition and preparation conditions for strong wort
Authors: Serba E. M. , Rimareva L. V. , Overchenko M. B. , Ignatova N. I. , Medrish M. E. , Pavlova A. A. , Sokolova E. N.
Published: October 2021

Abstract: Development of sustainable biotechnologies for deep processing of grain raw materials requires effective mechanisms of obtaining strong wort for alcohol production. To provide qualitative characteristics of biochemical composition and rheological properties of strong wort, it is necessary to select optimal enzyme systems and conditions for deep conversion of high-molecular weight polymers of the grain. Previous research has proven the efficiency of carbohydrases for processing grain raw materials. However, there is little evidence on the catalytic effect of phytase, including in combination with other hydrolytic enzymes, on the degree of hydrolysis of polymers in grain raw materials when preparing strong wort. This paper demonstrates the effect of proteases and phytases in a multi-enzyme composition, as well as the conditions of enzymatic processing of raw materials, on the rheological and biochemical parameters of strong wort. Wheat, rye and corn were investigated. The synergism of the combined effect of studied hydrolases, including phytolytic and proteolytic enzymes, contributed to an increase in polymer conversion in this grain raw material and the concentration of soluble dry substances of the wort by 1.5 times. Using the proteases and phytases in the multienzyme composition allowed the concentration of the following components in the wort to be increased: glucose – by 1.2–1.3 times; amine nitrogen – by 1.5–2.2 times; phosphorus ions – by 1.4–4.3 times. Additionally, in the wort samples, the content of amino acids in the free form increased by over 4 times. It is shown that the pretreatment of grain raw materials at a temperature of 80–90ºС for 6 hours and saccharification for 1–2 hours using a complete complex of enzymes containing α-amylase, glucoamylase, xylanase, protease and phytase, allows a strong wort with a dry matter content of over 30% to be obtained. Moreover, a significant decrease in viscosity was noted (particularly for rye wort – by 1.3–1.9 times). Our results confirm the essential role of enzymes exhibiting substrate specificity to protein and phytic polymers in grain raw materials.
Nitric acid solution after treating miscanthus as a growth regulator of seed peas (Pisum sativum L.)
Authors: Skiba E. A. , Skiba M. A. , Pyatunina O. I.
Published: October 2021

Abstract: All over the world, miscanthus is positioned as an extremely promising and rapidly renewable cellulose- containing raw material for the production of a large number of substances of chemical and biotechnological synthesis. The Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch оf the Russian Academy of Sciences has been developing its own methods of treating miscanthus using diluted solutions of nitric acid. While the amount of a waste solution (liquid phase) is 20 times greater than the target product — a solid phase -- intended for enzymatic hydrolysis and further microbiological synthesis of bioethanol, bacterial cellulose and other valuable products. The hypothesis states that a nitric acid solution after treatment with miscanthus, which was neutralized with ammonium hydrate (hereinafter referred to as the preparation), is a combined lignohumic fertilizer. Testing this hypothesis has required studying the growth-regulating activity of the preparation using the example of sowing pea seeds. The results show that, depending on the degree of dilution and the exposure time, the preparation acts in two ways: either as a stimulant or as a growth inhibitor. Thus, at a dilution rate of 1:10, the preparation acts as an inhibitor, and at a dilution rate of 1:1,000,000, its effect ceases. The working range includes the dilution rate between 1:100 and 1:10,000, when an increase in germination energy and rate is observed by 2–6% compared to the control and root growth is stimulated by 21–29%, i.e. an auxin-like growth-stimulating effect is observed. With prolonged endurance during the 4th day, the preparation showed a growth-inhibiting effect, indicated by the decrease in the germination energy and rate, the length of the stems and roots of the sowing pea. The new preparation showing growth-stimulating activity under certain conditions, supposedly confirms the hypothesis that it is a combined lignohumic fertilizer.
Obtaining a nanosized silica-humic preparation and its initial approbation
Authors: Smirnova Yu. D. , Rabinovich G. Yu. , Fomicheva N. V.
Published: October 2021

Abstract: The recent decades have witnessed a significant development and implementation of nanotechnology, including in various branches of agriculture. There is an active search for ways to obtain preparations for plant growing with nanoparticles that can be more rapidly involved in the metabolic processes of plants. This article aims to obtain a nanosized silica-humic preparation and its approbation on potato plants. As a source of humic substances, a liquid humic preparation BoGum (developed by the All-Russian Research Institute of Reclaimed Lands) was used, as a source of silicon – sodium metasilicate. Ultrasonic dispersion method was used for achieving the nanoscale of the samples. A silicon source was introduced in an amount of 0.1% (of SiO2) into BoGum, followed by the application of ultrasonic action for 5, 10, 15 and 20 minutes. The analysis of the obtained samples using a 90 Plus/MAS particle size analyzer has shown that with increasing dispersion time, the effective particle diameter changed insignificantly. At the same time, a redistribution of particles was noted: when the samples were exposed for 20 minutes, the number of smaller particles increased. After 5 minutes of treatment, the range of particle distribution was 115±13–830±23 nm, after 20 minutes of exposure, the particle diameter fell into two regions: 81±8–120±10 and 280±4–470±18 nm. Ultrasonic action contributed to the retention of the stable state of aggregation of the obtained preparation, larger microbiological activity and larger content of humic acid in comparison with the silica-humic preparation, obtained without the application of an ultrasound. The new nanosized silica-humic preparation has been tested on potato plants. Treatment of tubers before planting, followed by foliar spraying of vegetative plants, has contributed to an increase in potato yield by 18.7%. Changes were noted in the content of mono- and polysilicic acids in the soil, as well as the accumulation of silicon in the tops of potatoes when using silicahumic preparations by 0.96% of absolute dry mass on average.
Prediction of the biological activity of a compound depending on its NH-acidity
Authors: Nedvetskaya G. B. , Aizina Yu. A.
Published: October 2021

Abstract: Acetamides are building blocks for the synthesis of compounds containing pharmacophores in their structure, manifesting a diverse range of biological activity. The drugs based on these substances possess antidiabetic effect and inhibit blood coagulation. Some of them act as chemosensitizers (i.e., cancer cell inhibitors). However, the full potential of these compounds remains to be fully accomplished. In a previous study, we synthesised acetamides with the RCONHCH (R´) CCl3 general formula (where R = CH3, CH2Cl; R´ = C6H5, C6H4CH3, C6H4OCH3, C6H4OH) and studied their acid-base behaviour. The NH-acidity of the studied acetamides is controlled by the polar effects of substituents. In this paper, the potential biological activity of the previously obtained acetamides is calculated, and the dependence of their biological potential on the NH-acidity values is elucidated. Prediction of biological activity was carried out using the PASS software. An analysis of the types of biological activity occurring in all compounds allowed us to determine a linear dependence between the probability of biological potential and the value of dissociation constant.
Monitoring and assessment of the effect of benzo (a) pyrene for coniferous and deciduous plants in anthropogenically polluted areas
Authors: Belykh L. I. , Poley N. Yu.
Published: October 2021

Benzo (a) pyrene content in plants and soils in anthropogenically polluted areas pollution was monitored. The influence of benzo (a) pyrene on conifers and deciduous plants was assessed. In forests with Scots pine (Pinus sylvestris L.) and silver birch (Betula pendula) trunks, the content of lignin, cellulose, and extractive low molecular weight polar substances was determined by the concentration of benzo (a) pyrene and tree species. In forest ecosystems, the background content of carcinogen (1–5 μg / kg) did not affect the content of lignin and cellulose, but stimulated the synthesis of extractive substances, especially in birch. For pine, there was a direct correlation between the concentration of benzo (a) pyrene in two -year-old needles and its peroxidase activity. An increase in the activity of oxidoreductases and their participation in the synthesis of phenolic, tannin and other organic (extractive) substances, depending on the concentration of benzo (a) pyrene, indicate its biostimulating properties. Various physiological and biochemical reactions in woody and herbaceous plants were analyzed depending on the concentration (dose) of benzo (a) pyrene in the composition of plants and in soils polluted by anthropogenic emissions. Opposite reactions of coniferous and leafy trees to benzo (a) pyrene were observed. On the basis of own and published data, the natural, intermediate transitional and technogenic ranges of benzo (a) pyrene concentrations have been identified; among which the effect on plants varies from stimulating to inhibitory.
Methodological approaches to the construction of a risk structure model for investment construction projects in the field of occupational safety and health
Authors: Agoshkov A. I. , Kurochkin P. A.
Published: October 2021

Investment construction projects are implemented under constant changes, which forces managers to assess the uncertainty and risks they generate, to manage changes in their own activities and activities of construction organizations. The article describes the main methodological approaches to the development of a model of risks of investment construction projects in the field of labor safety and protection. The approach is based on the method of quantitative assessment depending on the level of processes being evaluated and data characterizing these processes. The proposed concept will make it possible to develop an algorithm and a computational and analytical model for the subsequent automation of the process of quantitative assessment of risks and the dynamics of their change on the basis of the information-digital system. For example, the Corporate Occupational Safety Management System, developed and used by NIPIGAZ JSC to manage occupational safety processes, ensure industrial and fire safety, environmental protection, will make it possible to put into practice the methods of predictive and operational risk analysis, increasing the efficiency of the investment construction project.
Dust distribution from common minerals in the air of the Baikal Natural Territory
Authors: Aleksandrova A. Yu.
Published: October 2021

In mountain quarries, the main factor influencing safety is dust aerosol of host rocks in the air. Therefore, it is necessary to ensure the environmental safety of mining quarries and improve health of the population. Due to a large number of factors influencing the distribution of dust, one of the main ways to obtain reliable information about this process is to study the distribution of dust. On the example of five mining facilities, an environmental risk assessment was conducted using statistical data on the control over activities of the enterprise. The index of atmospheric pollution was determined and the main parameters of the distribution of dust aerosols of granite, migmatite, marbled limestone, ophiocalcite, serpentinite, jade and charoite were identified. The area of distribution of dust aerosol for five quarries located on the Baikal natural territory was established. The consequences of dust pollution for ecosystems were described.
The Study of the Old Estates of the Northwestern Black Sea Region of Ukraine in the Aspect of Increasing the Recreational and Tourist Potential
Authors: STOROZHUK Svitlana , PRONCHENKO Andrii
Published: October 2021

The paper is devoted to the study of cultural and natural sights of the Northwestern Black Sea region of Ukraine, revealing their historical significance, unique architectural and urban planning solutions, and favorable location. The study identified and analyzed manors that have survived in the suburban areas of large cities. In world practice, examples have been identified of preserving the cultural and natural heritage of suburban areas through the development of their recreational and tourist potential. On the basis of the investigated cultural and natural attractions of the Northwestern Black Sea region, weekend tourist routes have been developed. The main focus of scientific work is on the study and conservation of natural resources and unique historical palaces and estates on the example of the palace of the Kurisov family. This makes it possible to use effectively recreational areas to create an ecologically clean, comfortable environment for recreation of the population and the development of domestic tourism, as a result of the current global pandemic of the coronavirus infection COVID-19, which caused the closure of the borders of many foreign countries.
Potensi Keanekaragaman Flora Sebagai Tumbuhan Obat di Wana Wiyata Widya Karya, Sanggar Indonesia Hijau, Kabupaten Pasuruan
Authors: Hildasari Nourma , Hayati Ari
Published: October 2021

Tumbuhan merupakan komponen keanekaragaman hayati yang menjadikan Indonesia memiliki kekayaan alam terbesar urutan kedua di dunia. Salah satu pemanfaatan fungsi tanaman adalah sebagai tanaman obat. Tumbuhan obat adalah bahan yang berasal dari tumbuhan yang masih sederhana, murni, belum tercampur atau belum diolah, yaitu tumbuhan yang tinggal dipetik dan diracik, kemudian langsung dikonsumsi. Penelitian ini bertujuan untuk mengetahui jenis tumbuhan obat yang terdapat di Wana Wiyata Widya Karya, Sanggar Indonesia Hijau, Kabupaten Pasuruan dan jenis organ tumbuhan obat yang digunakan sebagai obat. Metode yang digunakan adalah penelitian deskriptif melalui metode jelajah dan pengambilan spesies di area penelitian. Hasil inventarisasi menunjukkan bahwa tumbuhan yang berkhasiat sebagai obat berjumlah 55 jenis yang berasal dari 34 famili. Jenis organ tumbuhan yang berkhasiat obat teridentifikasi sebanyak 10 bagian. Presentase organ tumbuhan obat yang paling banyak digunakan untuk keperluan obat adalah daun dengan nilai 47%, buah 27%, biji 7%, rimpang 5%, getah 4%, serta kulit pohon, umbi, bunga, tangkai daun, dan batang masing-masing sebanyak 2%.
SOBRE O RACISMO QUE SOBROU
Authors: Oliveira Domingos Fernanda
Published: October 2021

A poesia propõe uma visão crítica do olhar racista e colonialista que vitimou os nativos à escravidão, e que, diante do abandono sem suporte, os abandonou pelas ruas. De tal modo que até hoje a segregação e o abandono é notado como outra face do mesmo racismo dos tempos coloniais.
EVOLUÇÃO NO CONHECIMENTO BIOMÉDICO E TIPIFICAÇÃO DO CRIME DE TRANSMISSÃO DO HIV
Authors: Grazinoli Garrido Rodrigo , Gonçalves da Costa Gabriela , Eudes Medeiros Esdras
Published: October 2021

Com a pandemia da Síndrome da Imunodeficiência Humana Adquirida (SIDA), a partir dos anos de 1980, surgiram questões que ultrapassaram a área médica, alcançando o Direito, especialmente no que concerne a transmissão dolosa do Vírus da Imunodeficiência Humana (HIV), causador da doença. Buscou-se demonstrar como a evolução do conhecimento biomédico influenciou o Direito Penal, levando a mudanças na tipificação da conduta criminosa de transmissão do HIV. Para tanto, realizou-se pesquisa exploratória e qualitativa, a partir de documentação indireta de fontes nacionais e internacionais, bem como da legislação, doutrina e jurisprudência a respeito da conduta de transmissão dolosa do HIV. Constatou-se mudanças nas tipificações penais, seguindo a evolução do conhecimento científico. Contudo, as discussões não foram completamente pacificadas. De toda forma, o conhecimento biomédico sobre o HIV/AIDS tem possibilitado ações penais mais consistentes, baseadas em provas técnicas conclusivas.
ANÁLISE CRÍTICA DAS MANIFESTAÇÕES CULTURAIS COMO FORMA DE ARRANHAR AS DURAS PAREDES DO NARCISISMO JURÍDICO E SUBVERTER O GENOCÍDIO NEGRO
Authors: Vieira Melo Marcos Eugênio , Da Silva Ferreira Melo Marcus Vinicius
Published: October 2021

O presente trabalho analisa como a leitura crítica das manifestações culturais – em foco o estilo musical rap – contribui para uma transdisciplinaridade no Direito, evitando o engessamento do saber jurídico e suas nefastas consequências. Para tanto, o artigo é feito através da análise do discurso de algumas letras de rap, bem como da revisão bibliográfica, realizada através de consultas a artigos científicos e livros referentes ao marco teórico, o qual tem como principais expoentes, além dos estudos de Antonio Gramsci, os conceitos formulados por Michel Foucault e as teorias da criminologia pós-moderna. Este estudo explora o positivismo jurídico e quem são os “fabricantes legítimos” desse saber em contrapartida com os detentores do conhecimento popular, que ajudam a construir um sistema penal democrático. Conclui-se como imprescindível a abertura do Direito para outros saberes, de modo que isso contribua inclusive para a análise e combate do racismo sofrido por comunidades marginalizadas.
PANDEMIA E SISTEMA PRISIONAL: TRAGEDIA OU PACIENTE?
Authors: CARVALHO Sandra Maria Souza de
Published: October 2021

poesia
O IMPACTO DA PANDEMIA DO CORONAVÍRUS NO SISTEMA PRISIONAL BRASILEIRO
Authors: Raupp Menger Luiza
Published: October 2021

Após fazer um panorama sobre o recrudescimento massivo dapopulação prisional nos últimos anos, o presente artigo pretendeanalisar como se deu a disseminação da pandemia do novocoronavírus dentro dos presídios no primeiro semestre do ano de2020. Será avaliado de que forma as autoridades lidaram com a crise,quais medidas foram tomadas para frear a dispersão da doença e quaisforam as principais recomendações dos especialistas, considerando acomplexidade do cenário. Ainda, serão analisados os fundamentosutilizados em importantes decisões judiciais proferidas pelosTribunais.
DIÁLOGOS TRANSCONSTITUCIONAIS NO DIREITO PENAL:
Authors: Pereira Paes de Barros Isabela Maria , Poletine Advincula Maria Júlia
Published: October 2021

O presente artigo discorre sobre a rápida disseminação do novo coronavírus (COVID-19) dentro dos presídios brasileiros, trazendo à tona um diálogo com o que dispõe a criminologia crítica acerca das características coloniais do cárcere no Brasil, enraizado em um passado punitivo perpetuado através dos mecanismos de controle de corpos encarcerados. Assim, recorreu-se às denúncias em nível internacional e à má gestão das penitenciárias brasileiras no período pandêmico, que se tornaram fortes expositoras da necropolítica praticada pelo governo federal. Dessa forma, analisa-se como as instâncias internacionais, sob a égide do transconstitucionalismo, são importantes para a mudança de paradigmas nacionais. A metodologia de pesquisa é qualitativa, com análise documental de resoluções e relatórios oficiais da Organização dos Estados Americanos; pesquisa bibliográfica, em artigos acadêmicos e livros, e pesquisa jornalística. O trabalho conclui sobre a importância da ação de organismos externos e sobre a influência do direito internacional dentro da política criminal brasileira.
Molecular Link between Circadian Rhythmicity and Mood Disorders
Authors: Faltraco Frank , Palm Denise , Coogan Andrew , Simon Frederick , Tucha Oliver , Thome Johannes
Published: October 2021

Background:

The internal clock is driven by circadian genes [e.g., Clock, Bmal1, Per1-3, Cry1-2], hormones [e.g., melatonin, cortisol], as well as zeitgeber [‘synchronisers’]. Chronic disturbances in the circadian rhythm in patients diagnosed with mood disorders have been recognised for more than 50 years.

Objectives:

The aim of this review is to summarise the current knowledge and literature regarding circadian rhythms in the context of mood disorders, focussing on the role of circadian genes, hormones, and neurotransmitters.

Method:

The review presents the current knowledge and literature regarding circadian rhythms in mood disorders using the Pubmed database. Articles with a focus on circadian rhythms and mood disorders [n=123], particularly from 1973 to 2020, were included.

Results:

The article suggests a molecular link between disruptions in the circadian rhythm and mood disorders. Circadian disturbances, caused by the dysregulation of circadian genes, hormones, and neurotransmitters, often result in a clinical picture resembling depression.

Conclusion:

Circadian rhythms are intrinsically linked to affective disorders, such as unipolar depression and bipolar disorder.
CRISPR Systems Suitable for Single AAV Vector Delivery
Authors: Stevanovic Marta , Piotter Elena , McClements Michelle E. , MacLaren Robert E.
Published: October 2021

CRISPR (clustered regularly interspaced short palindromic repeats)/Cas gene editing is
a revolutionary technology that can enable the correction of genetic mutations in vivo, providing
great promise as a therapeutic intervention for inherited diseases. Adeno-associated viral (AAV)
vectors are a potential vehicle for delivering CRISPR/Cas. However, they are restricted by their
limited packaging capacity. Identifying smaller Cas orthologs that can be packaged, along with the
required guide RNA elements, into a single AAV would be an important optimization for CRISPR/-
Cas gene editing. Expanding the options of Cas proteins that can be delivered by a single AAV not
only increases translational application but also expands the genetic sites that can be targeted for
editing. This review considers the benefits and current scope of small Cas protein orthologs that are
suitable for gene editing approaches using single AAV vector delivery.
Pharmacophore Based Design of Probable FGFR-1 Inhibitors from the 3D
Crystal Structure of Infigratinib - A Drug Used in the Treatment of
Cholangiocarcinomas
Authors: Sarker Koushik , Ghosh Avijit , Saha Abhijit , Mishra Suvasish , Sen Subrata
Published: October 2021

Background:

Pemigatinib (INCB054828) and Infigratinib (BGJ398) are the few selective
drugs that are approved by the FDA to treat cholangiocarcinoma, a rare form of bile duct cancer. Infigratinib
is a pan FGFR inhibitor and has been found promising in Phase-3, first-line PROOF clinical trial. So,
screening drug-like compounds having similar pharmacophoric features like infigratinib is the inspiration
of the present work.

Objective:

The objective was to identify drug-like compounds with similar pharmacophoric features as in
infigratinib. The compounds screened through the 3D query pharmacophore of infigratinib were also
predicted for ADMET properties so that the compounds may have good bioavailability.

Method:

A pharmacophore was generated from the crystal structure of infigratinib with several pharmacophoric
features such as hydrogen bond donor, hydrophobic, positive ionizable, and ring aromatic.
MayBridge database containing 65,263 compounds was used for virtual screening (VS) using LibDock.
The initial Hit compounds were subjected to ADMET predictions. Finally, two Hit compounds were selected
and docked with the FGFR-1 receptor to predict the interaction of the ligand atoms with the amino
acid residues of the receptor's active site.

Result:

The fit score for infigratinib, N-(4-fluorophenyl)-2-(5-((2-(4-methoxy-2,5-dimethylphenyl)-2-
oxoethyl)thio)-4-methyl-4H-1,2,4-triazol-3-yl)acetamide (Hit-1) and 4-(4-((2-(5,6-dimethyl-1H-benzo[d]
imidazol-2-yl)ethyl)carbamoyl)pyridin-2-yl)-1-methylpiperazin-1-ium (Hit-4) is 4.58901, 4.36649, and
3.71732, respectively. The LibDock score of infigratinib, Hit-1, and Hit-4 is 122.474, 123.289, and
123.353, respectively. The binding affinity score (-PLP1) of infigratinib, Hit-1, and Hit-4 is -143.19, -
102.72, and -91.71.

Conclusion:

The present study concluded that the two compounds designated as Hit-1 and Hit-4 have
been identified as binders of FGFR-1, and Hit-4 occupies the whole pharmacophoric space of infigratinib,
and both the compounds LibDock scores are better than the infigratinib. The two compounds Hit-1 and
Hit-4 may be synthesized and studied for their enzyme inhibition assay on FGFR-1 and biologically evaluated
on different cell lines for Cholangiocarcinoma.
Inhibition of ERN1 Signaling is Important for the Suppression of Tumor Growth
Authors: Minchenko Oleksandr H. , Tsymbal Dariia O. , Khita Olena O. , Minchenko Dmytro O.
Published: October 2021

Background:

Endoplasmic reticulum to nucleus signaling 1 (ERN1) is a major signaling
pathway of endoplasmic reticulum stress and is crucial for malignant tumor growth.

Objective:

The article aims to discuss the recent progress in the discovery of endoplasmic reticulum
stress targets and their involvement in tumor growth.

Methods:

Literature from the PubMed database related to the endoplasmic reticulum stress involvement
in the tumor growth and chemoresistance was searched and reviewed.

Results:

The endoplasmic reticulum stress plays an important part in malignant tumor growth and
is involved in invasion and metastasis. Inhibition of protein kinase and endoribonuclease activities
of the ERN1 signaling protein significantly reduces tumor growth through down-regulation of angiogenesis
and cell proliferation but activates the invasion. ERN1 knockdown affects the expression
of many genes associated with the regulation of apoptosis, cell proliferation, and survival as
well as reprograms the hypoxic regulation of most gene expressions. Simultaneously, inhibition of
ERN1 endoribonuclease only has a stronger suppressive effect on tumor growth and decreases the
invasiveness.

Conclusion:

Present review summarizes the recent advances in inhibiting ERN1 signaling that regulates
tumor growth. Further understanding of the regulatory mechanisms of genome reprogramming
upon inhibition of ERN1 signaling may help discover new possibilities for developing novel
effective therapeutics.
Microwave-Assisted Domino Cyclization Reactions
Authors: Wagh Yogesh B. , Dalal Dipak S.
Published: October 2021

Background:

Microwave-assisted domino cyclization reactions have attracted great interest
for researchers to synthesize complex compounds in shorter times with increased yields.
The domino reactions were used in various synthetic approaches and many drug deliveries in medicinal
chemistry with microwave-assisted approaches.

Methods:

Microwave irradiation has been applied for various domino reactions. The research related
to microwave-assisted domino cyclization was reviewed and the important methodologies
were collected from 2011-2021.

Results:

Only those methodologies that involve microwave-assisted domino cyclization reactions
during synthesis in a related manner have been reviewed. Along with some recent syntheses that
are microwave-assisted regarding new heterocyclic moieties are summarized.

Conclusion:

Microwave-assisted domino cyclization reactions can be employed to quickly explore
and increase molecular diversity in synthetic chemistry. We hope that this review will be helpful
to find out complex molecule synthesis by microwave-assisted domino cyclization reactions.
This review aimed to explain the applications of microwaves for the domino reactions from 2011-
2021. In this respect, microwave-mediated methods help researchers to make helpful studies.
Traceability model system as originality assurance method for honey product, Indonesia
Authors: Putritamara Jaisy Aghniarahim , Yuniarti Rahmi , Kusumastuti Anie Eka
Published: October 2021

Honey is a hype product as immunity booster in the health shock covid-19. Unbalance of supply and demand has raised the price and made the consumer could not afford it. Besides that, global issue about unoriginal honey which spreads in society has made the consumer has negative stigma on SMEs honey product because it does not have complete food safety certification as commercial company. Objective of the research was to increase the consumer trust through originality assurance for honey product from traceability system. The research is a case study with FGD method and then followed by Interpretive Structural Modeling (ISM) analysis and Business Process Notation as solution. Result of the research showed that the distribution aspect has great power to affect the stakeholder and logistic aspects, due to success of both aspects are determined by distribution aspect. While the stakeholder aspect does not have any power to affect other aspect because if the business system has correct SOP, then both aspects will have appropriate supply chain management. Therefore, the solution is business process improvisation, so that to increase the trust local brand for honey product, it must be optimized through recording system of customer journey, so that the producer could trace the barrier and enabler factors about perspective of the honey originality
Effect of Electronic Device Addiction on Sleep Quality and Academic Performance Among Health Care Students: Cross-sectional Study
Authors: Qanash Sultan , Al-Husayni Faisal , Falata Haneen , Halawani Ohud , Jahra Enas , Murshed Boshra , Alhejaili Faris , Ghabashi Ala’a , Alhashmi Hashem
Published: October 2021

Background

Sleep quality ensures better physical and psychological well-being. It is regulated through endogenous hemostatic, neurogenic, and circadian processes. Nonetheless, environmental and behavioral factors also play a role in sleep hygiene. Electronic device use is increasing rapidly and has been linked to many adverse effects, raising public health concerns.

Objective

This study aimed to investigate the impact of electronic device addiction on sleep quality and academic performance among health care students in Saudi Arabia.

Methods

A descriptive cross-sectional study was conducted from June to December 2019 at 3 universities in Jeddah. Of the 1000 students contacted, 608 students from 5 health sciences disciplines completed the questionnaires. The following outcome measures were used: Smartphone Addiction Scale for Adolescents–short version (SAS-SV), Pittsburgh Sleep Quality Index (PSQI), and grade point average (GPA).

Results

The median age of participants was 21 years, with 71.9% (437/608) being female. Almost all of the cohort used smartphones, and 75.0% (456/608) of them always use them at bedtime. Half of the students (53%) have poor sleep quality, while 32% are addicted to smartphone use. Using multivariable logistic regression, addiction to smartphones (SAS-SV score >31 males and >33 females) was significantly associated with poor sleep quality (PSQI >5) with an odds ratio of 1.8 (1.2-2.7). In addition, male gender and older students (age ≥21 years) were significantly associated with lower GPA (<4.5), with an odds ratio of 1.6 (1.1-2.3) and 2.3 (1.5-3.6), respectively; however, addiction to smartphones and poor sleep quality were not significantly associated with a lower GPA.

Conclusions

Electronic device addiction is associated with increased risk for poor sleep quality; however, electronic device addiction and poor sleep quality are not associated with increased risk for a lower GPA.