bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural Basis of DNMT1- and DNMT3A-Mediated DNA Methylation
Authors: Ren Wendan , Gao Linfeng , Song Jikui
Published: November 2018

DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating gene expression, genomic stability and cell lineage commitment. Establishment and maintenance of DNA methylation in mammals is achieved by two groups of DNA methyltransferases: DNMT3A and DNMT3B, which are responsible for installing DNA methylation patterns during gametogenesis and early embryogenesis, and DNMT1, which is essential for propagating DNA methylation patterns during replication. Both groups of DNMTs are multi-modular proteins, containing a large N-terminal regulatory region in addition to the C-terminal methyltransferase domain. Recent structure-function investigations of the individual domains or large fragments of DNMT1 and DNMT3A have revealed the molecular basis for their substrate recognition and specificity, intramolecular domain-domain interactions, as well as their crosstalk with other epigenetic mechanisms.   These studies highlight a multifaceted regulation for both DNMT1 and DNMT3A/3B, which is essential for the precise establishment and maintenance of lineage-specific DNA methylation patterns in cells. This review summarizes current understanding of the structure and mechanism of DNMT1- and DNMT3A-mediated DNA methylation, with emphasis on the functional cooperation between the methyltransferase and regulatory domains.
Synthesis and Characterization of NiO Nanoparticles using Manihot esculenta Aqueous Extracts
Authors: Escobar Morales Beatriz , Lucio Garcia Monica , Barbosa Romeli , Morales Acosta Diana
Published: November 2018

Synthesis of nickel oxide nanoparticles (NiO NPs) is a low cost and ecofriendly route that brings great benefits over chemical and physical methods of synthesis. Our approach consisted of using aqueous extracts from treated waste of Manihot Esculenta (Cassava) as reducing, stabilizing and capping agents for the synthesis of NiO NPs. The results proved this approach might be a viable alternative. Extracts were mixed during 30 minutes with Ni(NO3)2.6H2O leading to NPs formation. NiO NPs were characterized through FTIR, XRD, TEM and Raman spectroscopy. NiO NPs showed different shapes and sizes around 5-10 nm in agreement with the particle size calculated by XRD Scherrer equation.
The Role of Substrate Type, Moisture and Temperature on the Vertical Growth of Terricolous Lichens
Authors: Monge-Nájera Julián
Published: November 2018

Lichens are traditionally divided into short “crustose”, intermediate “foliose” and tall “fruticose” types, a practice that hides a growth continuum. Substrate, temperature and water are thought to affect vertical growth, but such factors are difficult to measure, because, for example, the water actually available to lichens does not match rainfall patterns or even ground water levels. To reliably assess the effect of those factors, I recorded temperature, moisture, and substrate in and under individual terricolous lichen colonies in 60 fixed quadrats on April, August, October, and December of 2015 (Cerro de la Muerte, Costa Rica, 9°33′N; 83°45′W). The measurements were taken inside the colonies themselves (rather than on the general environment), covering an annual cycle of the relatively simple páramo habitat, where animals and vegetation have less impact than in lower ecosystems. The hypotheses were that lichens would grow taller on softer, warmer, and moister ground; on the Caribbean versant; and on the rainy season. Results matched the hypotheses, with one exception: lichens on soft ground were not taller than those on rock. Caribbean colonies were, on the average, 7 cm taller than those on the drier Pacific versant. Physiologically available water seems to be the main determinant of lichen vertical growth: more water means taller lichens and greater protection from climatic change for both the lichens and their microcommunities.
Inonotus Obliquus extracts as an inhibitor of α-MSH-induced melanogenesis in B16F10 mouse melanoma cells
Authors: Lee Eunji , Cha Hwa Jun
Published: November 2018

Melanogenesis is a biosynthetic pathway for producing of the pigment melanin in human skin. Tyrosinase, a key enzyme, catalyzing is the first step in melanogenesis and the downregulation of the tyrosinase enzyme activity is the most reported method for anti-melanogenesis. According to the hyperpigmentation as an important issue in cosmetic industry, there is a big demand for melanogenesis inhibitors. In the present study, we identified the anti-melanogenic effect of Inonotus Obliquus in α-MSH-induced B16F10 mouse melanoma cells as a new inhibitor. Comparing with control and Inonotus Obliquus extracts treated B16F10, we identified melanin contents, tyrosinase activity, tyrosinase mRNA and protein expression, MITF activity using a constructed plasmid. As shown in these results, we demonstrated that Inonotus Obliquus extracts down-regulated melanin synthesis using down-regulating activity and expression of tyrosinase which is key enzyme to produce melanin. In addition, we revealed expression of tyrosinase is regulated by MITF through repressing MITF transcriptional activity. Inonotus Obliquus extracts has potential to repress melanogenesis and decreased of hyperpigmentation and to use as cosmetic ingredient.
Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma
Authors: Tumyan G. S.
Published: November 2018

Progress in the treatment of Hodgkin lymphoma are among the most significant achievements of oncology of our age. Nevertheless, an early relapse or refractory course of the disease account for approximately 15–20% of cases. It was this category of patients, in which the target drug brentuximab vedotin was successfully used for the first time. This is an anti-CD30 (a cell surface antigen) humanized monoclonal antibody conjugated via a protease-cleavable linker to the cytostatic agent monomethyl auristatin E, the potent tubulin inhibitor. This article describes the characteristics of CD30 antigen and a new preparation, as well as clinical data confirming its efficacy, the results of major reviews and research on the use of brentuximab vedotin in mono and combination therapy regimens at the different stages of treatment for Hodgkin lymphoma.
Intermediate results of combination therapy in patients with oligometastatic non-small cell lung cancer
Authors: Yudin D. I. , Laktionov K. K. , Marinov D. T. , Breder V. V. , Allakhverdiev A. K. , Borisova T. N. , Bekyashev A. H. , Laktionov K. P. , Aleshin V. A. , Ardzinba M. S.
Published: November 2018

At the present time, a small group of patients with oligometastases (who have a solitary metastatic lesion in another organ along with the primary tumour of the lung) is differentiated among the patients with metastatic lung cancer. A total of 14 patients of the study citied in this article underwent a comprehensive treatment of oligometastatic non-small cell lung cancer (ONSCLC), which included systemic therapy and local influence on solitary metastasis. The median overall survival for this group was 20 months (16.0–32.6, CI 95%). The 1-year and 2-year overall survival rates accounted for 84.5 and 65.7%, respectively. The findings of the study demonstrate the possibilities of an aggressive approach to the treatment of patients with ONLDLC.
Clinical case of long-term pemetrexed-based chemotherapy treatment for pulmonary adenocarcinoma (ALA +)
Authors: Lozhkina A. M. , Sviridenko M. A. , Cheremnykh A. O. , Filippova E. A. , Urtenova M. A. , Odintsova S. V. , Orlov S. V.
Published: November 2018

The article describes a clinical case of ALK-positive non-small cell lung cancer and its long-term treatment with a chemotherapy drug pemetrexed as first-line regimen followed by pemetrexed maintenance therapy.
Cytotoxic therapy for prostate cancer
Authors: Rusakov I. G. , Mishugin S. V.
Published: November 2018

Интервью с вице-президентом Российского общества онкоурологов (РООУ), врачом-онкологом Московской городской клинической больницы № 57, доктором медицинских наук, профессором Игорем Георгиевичем РУСАКОВЫМ и заведующим отделением онкоурологии ГБУЗ «ГКБ им. Д.Д. Плетнева», кандидатом медицинских наук Сергеем Владимировичем МИШУГИНЫМ.
Luteinizing hormone releasing hormone analogues in the treatment of patients with prostate cancer
Authors: Alexeev B. Ya. , Nyushko K. M. , Kaprin A. D.
Published: November 2018

Prostate cancer (PC) is the most pressing oncourological pathology due to a steady increase in morbidity and mortality from this pathology in the Russian Federation. The detection frequency of the common forms of the disease remains high. The combined chemo-hormonal therapy is the main method of treatment of metastatic prostate cancer. The refractoriness of the tumour to the ongoing castration therapy is an inevitable stage of the course of the disease in all patients receiving androgen deprivation therapy. However, castration therapy aimed at reducing endogenous testosterone in this cohort of patients should be continued. Eligard is one of the most studied drugs to conduct the drug castration therapy in patients with prostate cancer, which efficacy has been proven in numerous clinical studies in both continuous and intermittent mode using depot forms of various durations of action. The article presents a review of clinical studies that assessed the efficacy of Eligard therapy in different regimens and with the use of depot forms of various duration, which demonstrated equal effectiveness of such forms.
LOCATION UPDATEOF PROTECTED PLANTS ACCORDING TO HERBARIUM MATERIALS OF THE KEMEROVO STATE UNIVERSITY
Authors: Ковригина Любовь , Kovrigina Lyubov , Филиппова Александра , Filippova Alexandra , Тарасова И. , Tarasova I. , Романова Наталья , Romanova Natalia
Published: November 2018

The article provides information on the distribution of 38 species of vascular plants in the Kemerovo region that were not reflected in the second edition of the regional Red book. These data were obtained in the processing of herbarium collections compiled in 1969 – 2012 by teaching staff and students of the Kemerovo State University. As a result, 96 unknown localities of protected plants were revealed. More than 2/3 of herbarium specimens clarify the distribution of species in the administrative regions listed in the regional Red book, and the rest were collected outside. Only a small portion of the finds were confirmed by later compilations, data on the remaining locations do not exist, population monitoring in these localities was nit conducted. In this regard, to use the received information in a subsequent edition of the Kemerovo region Red book, it is necessary to conduct additional exploration of the territories, clarifying the fact of preservation of the populations and assessment of their condition.
MINING COMPANIES AND LOCAL COMMUNITIES: SOCIAL PARTNERSHIP AS THE BASIS OF CONFLICTFREE DEVELOPMENT (on the example of the province Batu Hijau, Indonesia).Review of: Enacting the Corporation: an American Mining Firm in Post-Authoritarian Indonesia by Marina Welker. Berkeley – Los-Angeles – London: University of California Press, 2014. 289 p.
Authors: Поддубиков В. , Poddubikov V.
Published: November 2018

The articlerepresents a review of the monograph by American anthropologist Marina Welker (Cornell University,USA), dedicated to the socioanthropological study of the relationship of the American industrial corporation Newmont leading mineral extraction on Sambava island (Indonesia), with the local population communities. Based on results of two-year field work, the author analyzes the most important aspects in terms of social tension in areas of intensive mining, the main components of the conflict discourse around the resource rent extraction and distribution problems, and the experience of the American corporation for the normalization of relations with local communities. The book under review is of considerable interest from the point of view of development in the Russian practice of socio-anthropological research in the problem field extractivism, its social and environmental development impact. This review is available to Russian-speaking reader for the first time. Previously, it has been published twicein foreign scientific journals in English [1] and Estonian [2]. 
TECHNOGENESIS OF SOIL IN COAL MINING AREAS OF KUZBASS
Authors: Заушинцена А. , Zaushintsena A. , Кожевников Н. , Koghevnikov N.
Published: November 2018

The article covers the problem of soil degradation caused by industrial activity. The paper discusses the current levels of landscape and environmental changes on the territory of Kuzbass coal deposits. The author tries to analyze the dependence of the environmental situation in the Kemerovo region on the condition of soil that was disturbed by mining. It was found that the impact of coal mining enterprises leads to disruption of the existing dynamic equilibrium in the biosphere, at both regional and global level. The necessity to introduce strict environmental monitoring of soil cover and binding works to restore disturbed areas was demonstrated.
GEOLOGICAL-GEOMORPHOLOGICAL CHARACTERISTICS AND NATURAL RESOURCES OF THE KEMEROVO REGION
Authors: Удодов Юрий , Udodov Yurii , Егорова Надежда , Egorova Nadezhda , Багмет Г. , Bagmet G.
Published: November 2018

The article deals with the geological structure, geomorphic features and mineral resources ofKemerovoregion. It describes stratified formation of late Precambrian (Riphean and Vendian), Paleozoic, Mesozoic and Cenozoic eras. The article considers four main tectono-magmatic stages of geological development of the area (posteritas-early Ordovician, Ordovician-Silurian, Devonian-late Permian and late Permian-Mesozoic). It enumerates the characteristics of the major tectonic elements of the Kuznetsk Alatau and Mountain Shoria, Salair and Tom ' -Kolyvan areas of the Kuznetsk coal basin. It lists deposits of iron, manganese, polymetallic lead-zinc and copper ore, aluminum raw materials. One of the oldest and valuable minerals of the region is gold. The coalbearing formations of the Kuznetsk coal basin described in the article are the largest of all the exploited coal basins of the world, in terms of reserves and quality of coal. The article lists non-metallic minerals, and the geography of their fields. It describes the main morphostructural elements: the Salair ridge, Alatau-Shor highlands, Tom ' -Kolyvan hill, the Kuznetsk basin and theChulymvalley.
ON «GEOGRAPHICAL» MATTER, INFORMATION AND MEASURE
Authors: Бутвиловский Владимир , Butvilovsky Vladimir
Published: November 2018

The tri-unity of matter-information-measure constitutes an «objective and subjective reality». Matter is something that can exist, act and transform. Information is all that is perceived as images, properties and effects of matter, but is not matter itself. Measure is the existing relationship of parts and types of matter and information, a variety of actual and possible states and transformations of matter. The article features the understanding of the object of geography as a science of noosphere, whose matter includes human beings and all the products of their activity and cognition. The noosphere is the human mind (global egregor), expressed in matter, information and measure, in a combination of the good and the evil, the intelligent and the stupid, the beautiful and the ugly. Its manifestation is expedient to generalize from ecological, aesthetic and economic positions. The initial element of noosphere, in which human reason and consciousness are reflected, is «the landscape». From this arises geographical information as character of state and development, expressed by the measure of geometrical parameters, energetic potential and human work.
RECREATIONAL PRESSURE, ITS IMPACT ON THE NATURAL ENVIRONMENT (THE CASE OF THE IVANOVSKIE LAKES)
Authors: Воротилина Наталья , Vorotilina Natalya , Орешкова Татьяна , Oreshkova Tatiana , Махрова Марина , Makhrova Marina , Денисова Ольга , Denisova Olga
Published: November 2018

The article is devoted to the rationale for the recreational impact on the «Ivanovskie lakes» natural site and the identification of problems connected with it. The data, obtained by questioning the recreants in the area, served as the basis for compiling the statistics and portraying the average tourist staying at the Ivanovskie lakes. According to the statistics, the area proved to be a rather popular recreational site, which makes it a serious impact factor on some natural components, such as the soil-vegetable cover, damaged mostly by road transport. To determine the degree of recreational digression of the soil and the flora destroyed by private transport. An analysis of a number of sites showed a fifth stage recreational digression, which was calculated by the transect method. In conclusion, the current paper offers a number of possible solutions for the identified problems: the rationale for the ecological load on natural complexes by establishing standards for recreational impact on them and restricting the passage of vehicles or improving the roads.
SECURITY OF MINING WORKERS WITH GOOGLE VR
Authors: Степанов Юрий , Stepanov Yury , Бурмин Леонид , Burmin Leonid
Published: November 2018

The current paper features the issue of the augmented reality technology application for instructing, training and knowledge testing of coalminers on safety precautions. In case of a change in the geomechanical situation or an emergency situation, this technology allows one to study the evacuation routes of mine workers, without going down the mine. The implemented software is integrated into the existing Geographic Information System (GIS), which makes it possible to create full-fledged industrial information systems. The paper mentions the advantages and disadvantages of traditional ways of providing security with the help of modern and advanced technologies aimed at risk minimization. It also describes the possibilities of using virtual reality technology and presents the results of a comparative analysis of existing virtual reality technologies. The article also features the implementation of the technology using the Google VR tools for the three-dimensional Unity3D environment and provides an example of its operation. Each mode of operation of the information system is described separately, providing guidance, training and control of processes to ensure the necessary safety level.
DETERMINATION OF THE WATER POLLUTION BY USING GEOGRAPHIC INFORMATION SYSTEM TECHNOLOGIES
Authors: Шлагов Дмитрий , Shlagov Dmitrii
Published: November 2018

The current paper deals with the determination of the sources and level of water pollution by using GIS-technologies. It describes the structure of the system, hardware and software, as well as a mathematical model, which examines the polluting impact of local enterprises, households and communal complex settlements. The system described makes it possible to identify enterprises that pollute the environment more than others, and to apply management decisions to regulate waste disposal processes at these enterprises. Also, at larger scale, the system allows municipalities to monitor the overall level of pollution in the agglomeration, which will allow them to make better decisions on the construction of new enterprises. A further research will create a smart system that will be able to predict the pollution of water bodies at different time intervals and identify how the ecological situation in one region depends on other regions of the Russian Federation.
Water quality assessment and plasmid analysis of multiple antibiotic-resistant Escherichia coli O157:H7 from well-water sources in Ado-Ekiti metropolis, Nigeria
Authors: Oluyege Jacob Olaoluwa , Adeoye Monisade Omolade , Olowe Busayo Mutiat
Published: November 2018

This research aimed to assess the physicochemical and bacteriological quality of underground water, and determine the antibiotic susceptibility and presence of plasmids in multiple antibiotic-resistant (MAR) Escherichia coli O157:H7 in underground water sources in Ado-Ekiti. Physicochemical and bacteriological analysis of water samples were carried out using standard methods, an antibiotic susceptibility test was investigated using the standard disc diffusion method and plasmid analysis of MAR isolates was carried out using the polymerase chain reaction (PCR) technique. The physicochemical parameters analyzed were within WHO recommendations except for pH and potassium while the water samples did not conform to the WHO bacteriological recommendations for drinking water. A total of 272 E. coli were isolated and identified, among which 150 isolates were non-sorbitol fermenters (NSF) and taken as presumptive E. coli O157. MAR to three and more classes of antibiotics used were observed among these NSF with high MAR-Index, >0.2. Plasmid analysis of selected 15 isolates among the MAR NSF showed that their resistance to antibiotics was likely plasmid-mediated as they carry one to two plasmids on them. The study revealed that the water samples from Ado-Ekiti metropolis are unsafe for consumption.
Apresentação
Authors: Lima Clovis Ricardo Montenegro de
Published: November 2018

Apresentação
Anotações Sobre O Tema Da Religião Na Nova Sociedade Pós-Secular
Authors: Siebeneichler Flavio Beno
Published: November 2018

Pretendo mostrar neste trabalho que a teoria crítica da sociedade construída sobre o conceito de agir comunicativo implica uma compreensão não convencional da religião. O tema da religião perpassa as várias fases obra habermasiana. Convém notar, todavia, que suas reflexões, apesar de não seguirem uma única linha de abordagem, buscam sempre aprimorar um critério que permita à sua filosofia pós-metafísica absorver potenciais semânticos da religião.
Reflexões sobre a ética do discurso
Authors: Siebeneichler Flavio Beno
Published: November 2018

A ética do discurso se caracteriza como uma posição filosófica que lança mão de um procedimento argumentativo, também caracterizado como discurso, a fim de solucionar problemas, dilemas ou conflitos morais na atual sociedade complexa, globalizada e multicultural. A ética do discurso tem sua origem nos trabalhos teóricos de Karl-Otto Apel e Jürgen Habermas. A ética do discurso, que constitui uma moral discursiva talhada para a vulnerabilidade de seres vivos que se individuam mediante socialização e comunicação, precisa resolver, ao mesmo tempo, duas tarefas: de um lado, postular respeito simétrico pela dignidade de cada um e, por outro, proteger as relações intersubjetivas através das quais os indivíduos se mantem como membros de uma comunidade. Habermas propoê um novo caminho, genealógico, cuja meta é a reconstrução crítica e hermenêutica do conteúdo deontológico inerentes a valores, normas, mandamentos e intuições éticas vigentes em uma sociedade.
Jürgen Habermas: Uma Teoria Da Comunicação Humana
Authors: Siebeneichler Flavio Beno
Published: November 2018

A comunicação pretende chamar a atenção para pontos fundamentais da teoria do agir comunicativo, de Jürgen Habermas, que está centrada na comunicação e na vulnerabilidade humana que é fruto da própria comunicação. Será utilizada uma estratégia de exposição dividida em três etapas: A primeira etapa terá duas séries de observações gerais sobre a vida e a obra de Habermas. Na segunda etapa o texto é concentrado em dois pontos de extrema relevância na teoria do agir comunicativo: aa relação dialética com a teoria de Emanuel Kant; e, o critério de acoplabilidade interdisciplinar entre princípios teóricos distintos o que lhe permite soletrar um projeto de teoria da sociedade entendida como crítica da razão ontológica. A terceira etapa abordará problemas derivados do conceito complexo e bipolar da sociedade que depende de possibilidades de acoplagem entre mundo da vida e sistema.
Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy
Authors: Jiao Peifu , Geng Qiaohong , Jin Peng , Su Gaoxing , Teng Houyun , Dong Jinlong , Yan Bing
Published: November 2018

Blockade of PD-1/PD-L1 interactions using PD-1/PD-L1 pathway modulators has shown unprecedented clinical efficacy in various cancer models. Current PD-1/PD-L1 modulators approved by FDA are exclusively dominated by therapeutic antibodies. Nevertheless, therapeutic antibodies also exhibit several disadvantages such as low tumor penetration, difficulty in crossing physiological barriers, lacking oral bioavailability, high manufacturing costs, inaccessible to intracellular targets, immunogenicity, immune-related adverse events (irAEs). Modulation of PD-1/PD-L1 pathway using small molecules may be an alternative approach to mobilize immune system to fight against cancers. In this review, we focus on summarizing the recently disclosed chemical structures and preliminary structure-activity relationships (SARs) of small molecules as PD-1/PD-L1 modulators for cancer immunotherapy.
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors
Authors: Yurttaş Leyla , Çavuşoğlu Betül K. , Çiftçi Gülşen A. , Temel Halide E.
Published: November 2018

Background:

1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities
including anticancer activity.

Objective:

In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized and evaluated for
determining their anticancer, anticholinesterase and lipoxygenase (LOX) inhibitory activity.

Methods:

All compounds were tested against C6 rat glioma, A549 human lung carcinoma and NIH/3T3 mouse
embryo fibroblast cell lines to define cytotoxic concentrations and apoptosis induction levels which they cause.

Results:

Many of the compounds exhibited remarkable potency that compounds 2a, 2b, 2e, 2h and 2j against C6
cells and compounds 2a, 2b, 2d, 2g, 2i, 2j against A549 cells were found more active than cisplatin. Compound
2d namely, 2-[(5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl)thio]-1-(4-chlorophenyl)ethan-1-one induced apoptosis
of A549 cells with 74.9% whereas cisplatin caused 70.9% percentage.

Conclusion:

Among them, compounds 2d and 2j against A549 cell line, compounds 2b and 2e against both
tumor cell lines showed selective cytotoxicity evaluating the inhibition concentration against NIH/3T3 cell line.
None of the compounds showed significant acetylcholinesterase (AChE) and lipoxygenase inhibitory activities.
Determination of Usnic Acid Responsive miRNAs in Breast Cancer Cell Lines
Authors: Kiliç Nil , Islakoğlu Yasemin Ö. , Büyük İlker , Gür-Dedeoğlu Bala , Cansaran-Duman Demet
Published: November 2018

Objective:

Breast Cancer (BC) is the most common type of cancer diagnosed in women. A common treatment strategy for BC is still not available because of its molecular heterogeneity and resistance is developed in most of the patients through the course of treatment. Therefore, alternative medicine resources as being novel treatment options are needed to be used for the treatment of BC. Usnic Acid (UA) that is one of the secondary metabolites of lichens used for different purposes in the field of medicine and its anti-proliferative effect has been shown in certain cancer types, suggesting its potential use for the treatment.

Methods:

Anti-proliferative effect of UA in BC cells (MDA-MB-231, MCF-7, BT-474) was identified through MTT analysis. Microarray analysis was performed in cells treated with the effective concentration of UA and UA-responsive miRNAs were detected. Their targets and the pathways that they involve were determined using a miRNA target prediction tool.

Results:

Microarray experiments showed that 67 miRNAs were specifically responsive to UA in MDA-MB-231 cells while 15 and 8 were specific to BT-474 and MCF-7 cells, respectively. The miRNA targets were mostly found to play role in Hedgehog signaling pathway. TGF-Beta, MAPK and apoptosis pathways were also the prominent ones according to the miRNA enrichment analysis.

Conclusion:

The current study is important as being the first study in the literature which aimed to explore the UA related miRNAs, their targets and molecular pathways that may have roles in the BC. The results of pathway enrichment analysis and anti-proliferative effects of UA support the idea that UA might be used as a potential alternative therapeutic agent for BC treatment.
Preliminary Study of Liquid Hydrocarbon Biodegradation By Indigineous Bacteria Isolated from Wonocolo Village, Bojonegoro District, East Java Province
Authors: Dwi Kusumo Bramono , Wilopo Wahyu , Retnaningrum Endah
Published: November 2018

Aquatic environmental pollution due to petroleum waste can cause disruption to the environment and damaging of flora and fauna. It has been reported that petroleum contaminatin occurs in the Bengawan Solo river, East Java Province. Liquid hydrocarbon waste pollution can be remediate through various processes, one of them is biodegradation. Biodegradation a part of bioremediation, is the process by which organic substances are decomposed by microorganisms into simpler substances such as carbon dioxide, water and ammonia. Bioremediation has minor side effects compare to other methods because it’s more effective, efficient, economical and eco-friendly through biological process. This study aims to identify bacteria for liquid hydrocarbon degradation from the rivers in Wonocolo Village, Bojonegoro District and to determine maximum percentage of inoculum to produce the highest efficiency of liquid hydrocarbons degradation. Based on phenotypic characters, the selected bacteria was identified as a genus of Moraxella. Its bacterium with a concentration of 2 % can reduce hydrocarbons to a maximum of 0.67 % per hour at the exponential phase growth.
KUALITAS AIR SUNGAI GAJAH WONG DITINJAU DARI PENGHAMBATAN ENZIM ASETILKOLINESTERASE (Water Quality Assessment of Gajah Wong River Based on Inhibition of Acetylcholinesterase Activity)
Authors: Riswanto Florentinus Dika Octa , Hariono Maywan , Susanto Gatot Nugroho , Budiasmoro Ignatius Yulius Kristio , Istyastono Enade Perdana
Published: November 2018

ASBTRAKSungai Gajah Wong, salah satu sungai di kota Yogyakarta, dikhawatirkan terpapar pencemaran air akibat pembuangan limbah rumah tangga, industri, rumah sakit maupun hotel yang masuk ke dalam alirannya. Hal ini menyebabkan penurunan kualitas air sungai dan menimbulkan dampak negatif bagi makhluk hidup yang memanfaatkannya. Pencemaran air sungai tersebut dapat diamati secara biokimiawi berdasarkan uji aktivitas penghambatan enzim asetilkolinesterase (AChE) oleh cemaran pestisida organofosfat dan karbamat. Uji biokimiawi dalam analisis kualitas air terhadap penghambatan AChE dapat dilakukan secara kolorimetrik menurut metode Ellman. Hasil reaksi ini dapat diamati secara melalui pembentukan senyawa berwarna dan serapannya dapat diukur pada panjang gelombang visibel. Penentuan lokasi sampling pada penelitian didasarkan pada pertimbangan sebaran muatan polusi/diffuse pollution loads consideration. Ditetapkan enam lokasi pengambilan sampel air sungai yaitu GW-1, GW-2, GW-3, GW-4, GW-5, dan GW-6 berturut-turut dari utara ke selatan. Dari keenam lokasi, GW-6 sebagai titik paling selatan dalam jalur pengambilan sampel menunjukkan penghambatan aktivitas AChE yang paling tinggi ditunjukkan dengan aktivitas AChE yang rendah. ASBTRACTGajah Wong River, one of the rivers in Yogyakarta city, was threatened by contamination of water pollutant due to the disposal waste of households, industrials, hospitals and hotels into its stream. The pollutions might cause the decreasing of water quality and raised the negative impact to living creatures that exploit it. River pollutions can be observed biochemically based on inhibition of acetylcholinesterase (AChE) enzyme activity by organophosphate and carbamate pesticide contamination. Biochemical assay in the analysis of water quality could be done according to the colorimetric of Ellman’s method. The results of this reaction can be observed by measuring the formation of colored compounds at visible wavelengths. Determination of the sampling location in this research was performed based on diffuse pollution loads consideration. Six sampling sites was defined and named as GW-1, GW 2, GW 3, GW 4, GW-5, and GW-6, respectively in a row from north to south. As the results, water from GW-6 as the southernmost site in the sampling sites showed the highest inhibition of AChE activity.
Application of Creative Experiential Marketing in Vanke Real Estate
Authors: Bi Wei , Wu Jun , Gao Yang , Lin Rungtai
Published: November 2018

With the continuous development of China’s real estate market and the continuous improvement of people’s living standards, the home buyers’ demand for emotional experience has been constantly aroused, thus making emotional experiential marketing more important in customer behavior. In the era of pursuing personalized experience, experiential marketing has become a powerful means for enterprises to achieve stRung competitiveness. It is usually connected with the creation of an atmosphere, an environment and a situation, the completion of a process and the making of a commitment, and sometimes it needs a customer’s active participation. This paper is based on Vanke’s real estate marketing, first gives a detailed introduction to the real estate experience in terms of the experience economy, experiential marketing and emotional experience, and then analyzes the application of experiential marketing in real estate marketing from product experience, user-friendly experience, scene setting experience and theme interactive experience to discuss how experiential marketing is implemented in Vanke’s real estate, learn from it and provide reference of effective experience for future researches.
Una nota desconocida de Rafael Dieste sobre Adolfo Pastor en la revista porteña Pensamiento español (1942).Tensiones y conflictos en el exilio republicano en Argentina
Authors: Núñez César
Published: November 2018

El artículo presenta una nota desconocida de Rafael Dieste sobre una exposición de dibujos y grabados del artista uruguayo Adolfo Pastor en la Galería Viau de Buenos Aires. Esta nota, aparecida en Pensamiento Español en 1942, es la tercera de las colaboraciones de Dieste en la revista que llevaba adelante un grupo de exiliados españoles. Se brindan datos bibliográficos precisos sobre los dos poemas que Dieste publicó en ella, ya conocidos gracias al tomo 1 de sus Obras completas, pero de los que no había mayor información. Asimismo, se describen los rasgos y vínculos editoriales más inmediatamente reconocibles con el fin de reconstruir el mundo cultural del exilio.
Robert J. Blake & Eve C. Zyzik, El español y la lingüística aplicada. Georgetown University Press, Washington, DC, 2016; 206 pp.
Authors: Cortés Gerardo
Published: November 2018

En el libro El español y la lingüística aplicada, Robert J. Blake y Eve C. Zyzik elaboran una propuesta interesante y por demás pertinente para relacionar los nuevos conocimientos lingüísticos del español con su enseñanza.
Cecilia Salmerón Tellechea, Macedonio Fernández: su conversación con los difuntos. El Colegio de México, México, 2017; 333 pp. (Serie Estudios de Lingüística y Literatura, 68).
Authors: García Carlos
Published: November 2018

El libro de Cecilia Salmerón Tellechea que ahora nos ocupa, ilustra, entre otras cosas, esa paradoja encarnada en Macedonio Fernández, padre de la vanguardia histórica argentina, de ser al mismo tiempo ultractual y sin embargo mirar de vez en cuando hacia atrás.
Jorge Luis Borges, Borges esencial. Ed. de José Luis Moure. Real Academia Española-Asociación de Academias de la Lengua Española, Rio de Mouro, 2017; 800 pp.
Authors: Cajero Vázquez Antonio
Published: November 2018

De acuerdo con la “Presentación” y el colofón de Borges esencial, esta sui generis antología conmemora el trigésimo aniversario de la muerte de Jorge Luis Borges.
Bibliografía de filología hispánica
Authors: De Filología Hispánica Nueva Revista
Published: November 2018

Las reseñas se consignan a continuación del libro (o artículo reseñado). Cuando éste se ha descrito en una entrega anterior de la Bibliografía, se pone entre paréntesis el número de ficha correspondiente. También se hacen referencias a ediciones anteriores de una obra, a tomos anteriores de una obra en curso de publicación, etc. En estos casos, la cifra que precede al número de referencia indica el volumen de la NRFH en que figura la ficha en cuestión. Así, el "núm. 39-39695" corresponde a la ficha 39695, la cual está en el volumen 39 de la NRFH. Cuando no hay cifra inicial, ha de entenderse que el número remite a una ficha incluida en el presente fascículo.
Winisis multiformato de UNESCO para el tratamiento de datos e información textual
Authors: Rueda Vildoso Hugo , Valenzuela Urra Cristián , Oliveros Castro Sergio
Published: November 2018

Se muestran y explican con ejemplos prácticos las posibilidades de tratamiento de datos e información textual que tiene el lenguaje de formateo de WINISIS de UNESCO al manipular cadenas y subcadenas de caracteres alfanuméricas no estructuradas o semiestructuradas, línea por línea, o párrafo por párrafo, de longitud fija o variable, especialmente en archivos lógicos de software (log), o provenientes de cualquier formato (Excel, Word, PDF u otro), convertidos a formato de texto plano norma ascii, para ser importados a través de programas en ISIS Pascal a CDS/ISIS. Se aplican expresiones y funciones (de cadena, numéricas o booleanas), expresiones, comandos, selectores de campos, subcampos y cadenas, para estructurar los datos y/o el texto, y obtener resultados de diseño de bases de datos, estadísticos y métricos.
Islamic Corporate Governance, Islamicityfinancial Performance Index And Fraudat Islamic Bank
Authors: Lidyah Rika
Published: November 2018

This research empirically tested the factors of fraud occurrence in sharia banks based on fraud triangle theory, which is motivation, opportunity and rationalization must be fulfilled for the occurrence of fraud. This research develops indicators as a proxy of motivation, opportunity and rationalization. Factors tested in this research is the Islamic Corporate Governance to fraud with the Islamicity Financial Performance Index as a mediator in sharia banks 2012-2016.This research using quantitative method with secondary data. Data are obtained from annual reports published by Islamic banks. The test is done by path analysis and processed using SPSS. The result of research shows that Islamic Corporate Governance has no effect to Islamicity Performance Index, Islamic Income Ratio, Profit Sharing Ratio and Islamic Investment Ratio (Islamicity Financial Performance Index) influence to Fraud, Islamic Corporate Governance has no effect to Fraud, and Islamic Income Ratio, Profit Sharing Ratio and Islamic Investment Ratio (Islamicity Financial Performance Index) does not mediate the influence of Islamic Corporate Governance to Fraud on Islamic Bank or it can be said that there is no mediation. This research shows that factors based on fraud triangle are effective for use in explaining fraud.
Death as a way of ‘freedom’ for Spirit to Eternity (Hindu Kaharingan Theological Perspective)
Authors: Etika Tiwi
Published: November 2018

Discussing about death has always been the most interesting issue of every religion in the world. Human fears death and do not want to die. For some people, death becomes so familiar that fear becomes daring, in some sense, they are ready to lose everything, or at least, no longer expects anything, as heroes did on the battlefield. Brhad-aranyaka Upanisad IV.3.36 has mentioned that: when this body starts to frail, whether it frails through old age or disease, just as a mango or a fig or a fruit of the Peplum tree releases itself from its bond (gets detached from its stalk), even so this person frees himself from these limbs and returns again as he came to the place from which he started back to a new life. Data was collected using desk study and analyzed using Hindu studies. The finding of this research that man as a descendant of Raja Bunu who inhabits this world will someday return to Ranying Hatalla through death. Life is temporary, as an exodus that someday will return to where we came from.  Just as policemen, magistrates, chariot-drivers, leaders of the village gathered round for king’s departure, or as breaths gather round at the end, when a person starts breathing difficultly or when he is about to die, that is when death is a way of ‘freedom‘ to the eternity.
Bayon Temple In The Development Of Budhisme In Cambodia
Authors: Kunthea Bopha
Published: November 2018

Cambodia is experiencing tremendous tourism developments. Many choices of tourist attractions that can be selected by tourists. Each tourist attraction provides interesting offers for tourists who visit. The existence of temples in Cambodia is the main attraction for tourists, so many temples start to become a tourist spot. Bayon Temple is one of the tourist attractions visited by tourists. Utilization of Bayon Temple as a tourist visit is a result of tourism development. These developments affect the social and cultural life of Buddhists in Cambodia.
Development Of Video Media Instructional Bhagavad Gita In Religious High School Hindu Lampung
Authors: Siti Nyoman , Koestoro Budi , Raka I Dewa Made
Published: November 2018

The objectives of this research are: (1) developing video media teaching materials of Bhagavad Gita, (2) to analyze the effectiveness of Bhagavad Gita video media use, (3) to analyze the efficiency of Bhagavad Gita video media, (4) to analyze the attractiveness of Bhagavad Gita video media. This research uses a research and development approach, conducted in religious high school hindu (STAH) Lampung. Data collection using tests and questionnaires and analyzed quantitatively and qualitatively. The conclusions of the study were (1) to produce teaching material of Bhagavad Gita video media consisting of eight elements, namely: (a) opening greetings, (b) introduction, (c) parts of Bhagavad Gita, (d) how to read, (e) types of mentrum, (f) examples, (g) self-assessment and (h) closing greetings. (2) video media teaching materials Bhagavad Gita effective with the average of the gain value in sequence is 0.71; 0.77; and 0.77. (3) Bhagavad Gita video media is efficient as a learning media of 1.7. (4) The video media instructional Bhagavad Gita is attractive in used as media video learning Bhagavad Gita  with the consecutive average percentage being 91%, 91%, and 92%.
The Challenge Faced by Hindu Women in Doing Their Swadharma in the Midst of Modernisation
Authors: Istri Agung I Gusti Agung
Published: November 2018

Hindu women who are already in the Grhasta period play an important role in the family. In their married life, women have several obligations for the harmony of their family. The word ‘woman’ comes from the word ‘wanită’, the feminine sex, which means beloved, wife, girl, woman, female (Semadi Astra, 2000: 372). Based on that sense, the word ‘woman’ means beloved, indicating that women are part of social life and family is part of the composition of social creatures that spread love to the surrounding environment, likewise their effort to enforce the Swadharma in their life. However, there are several obstacles regarding the efforts of women in implementing their Swadharma to create harmony in the family, society, and workplace.

The Hindu women in Bali began to show their existence in their family life, society, nation, and state. Women's participation in the family is very meaningful. A woman as a wife and mother in the family has an important role in creating the harmony of the family as well as mental development of her children. In addition to taking care of the family, now women also participate in helping the family finances. Hindu women in Bali do not want to be housewives only and ask the husband for the household expenses. Many women are now beginning to participate to help family finances by working at home and outside. Even some mothers really want to fight alone for their children. It simply proves that women can also act as the head of a family just as a father.
Religious Harmony Among Senior High School Students Multicultural Education Case Study in the Cova-Lima District of East Timor
Authors: Soares Francisco , Sudarsana I Ketut
Published: November 2018

Harmony is a state where there is mutual understanding, unity, cooperation, peace and friendship among members who live together for a purpose of nation and state. In addition it can also mean that harmony is a state that reflects mutual understanding and agreement among members so as to create peace and harmony. Religious harmony is not the religious teachings blend in the sense of mixing up the religious teachings, but the harmony between different religious faiths. Religious harmony can be realized if there is a tolerance among believers of different faiths. The attitude of tolerance is no other way by controlling yourself in attitude toward others, so that others do not feel harmed or threatened. The attitude of self-control is of course not just coming from one party. This should be done by every believer of different religions.
Theme, Message, and Hindu Ethics Teaching in Gaguritan Cangak
Authors: Yogantara I Wayan Lali
Published: November 2018

Gaguritan Cangak is classified as a classic literature that can be studied in terms of themes, messages, and teachings contained in it. The Gaguritan Cangak theme is the impact of good and bad deeds, the message delivered does not quickly believe to the promises or sayings of others, always be wary of self-salvation, and believe in the truth of karmaphala law. The Hindu ethic in Gaguritan Cangak emphasizes the teachings of karmaphala, that any good deeds will be good deeds and bad deeds will be bad. The doctrine of good deeds of human deeds is known by the teachings of Trikaya Parisudha and Tri Mala.
Salunglung Sabayan Taka: The Balinese Behavior in Toraja Translating the Original Culture
Authors: Samiyono David , Suardana I Made
Published: November 2018

This study aims to gain a deeper description of the cultural behavior of Balinese immigrants in Toraja in their encounter with local wisdom depicted the philosophy of "Salunglung Sabayantaka". From this study, it can be concluded that the philosophy of "Salunglung Sabayantaka" is still fundamental to the living habits of the Balinese although the life in the overseas ie Toraja which is detached from the ties of the pekraman village in Bali, as well as the bonds of their respective belief values.

The basic principles of the sabayantaka scroll that should be bound in the integrity of the custom village or the pekraman village have not undergone the significant changes in the fulfillment of life responsibilities, especially in their encounters with community life and local wisdom. The Balinese community in Toraja have been working on the behavior of salunglung sabayantaka life regardless the differences in beliefs and culture. The behavioral content of life is an evident in the presence of Balinese society in supporting the social responsibilities of the community in Toraja, in applying the example of salawatlung sabayantaka life and in educating the family as well as in society. The Balinese Mentality in Toraja, in relation to the philosophy of "Salunglung Sabayantaka" is the manifestation of the behavior of educating children measurably in placing the child as a whole part of family life, society and culture. This research will be a reference to build the living habits of the immigrant Balinese people in Toraja in their encounter with local wisdom, so that the Balinese cultural behavior in Toraja still supports the philosophy of "Salunglung Sabayantaka", so that every Balinese society in Toraja is definitely changing according to the dynamics of the society development. It continues to build the social contacts based on the combination of cultures that make up their cultural strengths.