bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive proportional derivative decentralized output based controller for a biped robotic device
Authors: Chairez Isaac , Alsmadi Yazan , Vera-Tizatl Pamela , Rincon-Martinez Karla
Published: September 2022

This paper describes the design and implementation of a novel adaptive control method to track a set of bioinspired reference trajectories. These references define anthropomorphic movements for an exoskeleton robot. The proposed controller implemented the adjustment laws for the variable gains of a state feedback (Proportional-Derivative type) structure. The method to adjust the adaptive gains was determined using a controlled Lyapunov function. The adaptation laws use velocity estimation based on a robust exact differentiator (RED) implemented as a variation of a distributed Super-Twisting algorithm. The adaptive gain controller was evaluated on a simulated exoskeleton structure. The set of simulations considered the presence of external disturbances and modeling uncertainties. The controller proved efficient in rejecting external perturbations/uncertainties affecting the exoskeleton. The proposed controller’s performance was superior to the one obtained if the standard fixed-gain proportional derivative controller was evaluated. As an additional benefit of the adaptive PD controller implementation, a controller power reduction of at least 14 [Formula: see text] concerning the non-adaptive version of the feedback controller was attained. An experimental evaluation of the proposed controller confirmed the benefits of the proposed controller with adaptive gains. The successful tracking of nine different biomechanically inspired reference trajectories justified the exoskeleton application, which could be used as a potential tool for rehabilitation purposes.
Call it misogyny
Authors: Loewen Walker Rachel
Published: September 2022

Misogyny is a weighty term. Its affective power invokes spectres of rape, sexual assault, hate-fuelled insults and gas-lighting. Its presence in nearly every culture on the planet haunts our pasts and frames our presents. Aiming to build an understanding of misogyny for our future social justice efforts, I look to Kate Manne’s Down Girl: The Logic of Misogyny, where she dusts off an old definition of misogyny as the hatred of women to describe it as the enforcement branch of a patriarchal society, a renewed engagement for feminists and activists alike. In particular, this framing provides opportunities to examine misogyny from an intersectional lens, including its intersections with race, gender and sexuality. For example, through stories such as that of Pamela George, an Indigenous woman from Regina, Saskatchewan who was murdered in 1995, I argue that it is crucial that we recognise the collusion between settler colonialism and misogyny. Or in the case of transphobic comedian Dave Chapelle, we must understand the interplay of heteronormativity and cisnormativity in propping up transmisogyny. Consequently, I argue that an intersectional logic of misogyny provides not only a shift but a tipping point for feminist and queer movements to come.
Trouble in virtual heaven: Origin and consequences of social conflict in online consumption communities
Authors: Kristiansen Adrian , Lindberg Frank , Tempelhaug Anders
Published: September 2022

This paper analyzes social conflicts among amateur computer gamers who are playing online multiplayer games. Whereas prior research tends to focus on the passion and fun of consumption community, or negative individual consequences of gaming, our research contributes with theorization of the role of social conflicts within and across gaming communities. The empirical data consists of two data collecting phases. We develop our understanding of gaming communities and culture through virtual ethnography and netnography. Then we conduct interviews with young adult gamers who belong to six communities. Our findings show four types of social conflicts; those between casual versus competitive logics, depending on skills and power, immoral behavior, and troubles of team alignment, which are related to routinized, prerogative or transgressive conflict cultures. We discuss how the study contributes with new knowledge on consumption-mediated social conflicts and suggest a model of the relationship between conflict cultures, conflict types and implications.
Acidic hydrolysis of recycled polyethylene terephthalate plastic for the production of its monomer terephthalic acid
Authors: Islam Muhammad Saiful , Islam Zahidul , Hasan Rashed , Islam Molla Jamal AHM Shofiul
Published: September 2022

Post-consumer polyethylene terephthalate (PET) plastic bottles, after some pre-processing, were chemically depolymerized for the production of terephthalic acid (TPA), an important monomer of PET resin. The optimized condition of PET hydrolysis was 100°C with 80% v/v aqueous sulfuric acid liquor for 30 min reaction time. The terephthalic acids (TPAs) were filtered out from the reaction mixtures with a sintered glass filter. The viscosity of recycled hydrolysis liquor was measured before it was used in a successive batch of PET depolymerization. The viscosity of hydrolysis liquor increased gradually from 5 mm2/s to 87 mm2/s. TPA yields were obtained from 85.03 ± 0.03% to 99.20 ± 0.06% and the color of TPA changed from bright white to off-white in the final batches. The structure of TPA was confirmed by FTIR, mass analysis, and 1H-NMR spectroscopy. The purity of TPA was found to be 95–98% from the HPLC study via external calibration technique. Thermogravimetric analysis (TGA) determined the thermal degradation patterns of TPAs and residual weights. This experiment reveals that repeated use of sulfuric acid hydrolysis liquor would be a good option for PET depolymerization in terms of resource utilization, TPA quality as well as sustainability.
War Metaphors (What Are They Good For?): Militarized Rhetoric and Attitudes Toward Essential Workers During the Covid-19 Pandemic
Authors: Blankshain Jessica D. , Glick David M. , Lupton Danielle L.
Published: September 2022

During the COVID-19 pandemic, leaders and society at large invoked militarized rhetoric and war metaphors to elevate essential workers and inspire collective action. Using a survey experiment we investigate whether this type of framing affects public views about (1) individual responsibilities, (2) targeted polices, and (3) perceptions of those called heroes and soldiers. We find that the war metaphor has minimal effects on public attitudes toward policies and individual actions in response to the pandemic. Framing the response in militaristic terms does, however, appear to affect perceptions of essential workers. Counter to our hypotheses, subjects who saw essential workers called heroes or soldiers viewed them as more motivated by compensation rather than service, and expressed less respect for them, than respondents in the control. These findings, including the nulls, make important contributions to our understanding of the limits of framing effects in a polarized context.
The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer
Authors: Chen Keyu , Wu Jiayi , Fang Ziru , Shao Xiying , Wang Xiaojia
Published: September 2022

Breast cancer is a kind of malignant tumor that seriously endangers women's life and health. Once diagnosed, most patients will receive a combination of treatments to achieve a cure. However, breast cancer is a heterogeneous disease. Even with the same clinical stage and pathological features, its response to treatment and postoperative recurrence risk may still be completely different. With the advent of genomic assay, some patients with early-stage breast cancer who originally needed treatment can still achieve long-term disease-free survival without adjuvant chemotherapy, so as to achieve personalized and accurate treatment mode to a certain extent. In this paper, we reviewed the 5 most widely used and studied genomic panel technologies in breast cancer, namely Oncotype DX, MammaPrint, RecurIndex, PAM50, and EndoPredict, according to accessibility and availability. Based on the results of the completed or ongoing clinical studies, we summarized the origin, applicable population, and clinical efficacy of each detection method, and discussed the potential development prospect of detection technology in the future.
The Association Between Dextromethorphan Use and the Risk of Dementia
Authors: Chen Chia-Yuan , Chung Chi-Hsiang , Chien Wu-Chien , Chen Hsin-Chien
Published: September 2022

Dementia is one of neurodegenerative disease without preventive medicine currently. Dextromethorphan (DXM) has been reported to reduce neuronal damage and neurodegeneration in animal and human models. The effect of DXM on the dementia has not been fully examined. We examined the medical records over 40 years old in Taiwan’s National Health Insurance Research Database between 2000 and 2015 to establish matched cohorts. We used a Cox regression hazard model to identify risk factors of dementia during 16 years of follow-up, and the results indicate that a significantly lower percentage of subjects with DXM use ( P < .001) developed dementia compared with those without DXM use (11.38%, 4541/39 895 vs 18.66%, 29 785/159 580). After adjustment for age and other variables [adjusted hazard ratio: .567 (95% confidence interval: .413-.678, P < .001)], this study also demonstrated that DXM use appeared to reduce the risk of developing dementia. DXM use may potentially provide a protective effect against dementia.
A qualitative analysis of Medicaid beneficiaries perceptions of prenatal and immediate postpartum contraception counseling
Authors: Yates Lindsey , Birken Sarah , Thompson Terri-Ann , Stuart Gretchen S , Greene Sandra , Hassmiller Lich Kristen , Weinberger Morris
Published: September 2022

Objectives:

In the United States, about four out of every ten births are financed by Medicaid, making it a program that is key in addressing racial disparities in maternal health. Many women covered by Medicaid have access to prenatal and immediate postpartum contraception counseling that can aid them in their postpartum contraception decision-making. However, existing inequities within Medicaid and a history of reproductive harms targeting Black women and women with low incomes may contribute to women with Medicaid having different experiences of contraception counseling. This qualitative study explores how Black women and White women insured by Medicaid perceive prenatal and immediate postpartum contraception counseling and identifies additional factors that shape their contraception decision-making.

Methods:

We conducted semi-structured interviews with 15 Medicaid beneficiaries who delivered at a public teaching hospital in North Carolina. Interviews focused on women’s beliefs about planning for pregnancy, experiences with prenatal and immediate postpartum contraception counseling, and perceived need for postpartum contraception. We used a priori and emergent codes to analyze interviews.

Results:

Seven Black women and eight White women completed interviews 14–60 days postpartum. All women reported receiving prenatal and immediate postpartum counseling. Several women described receiving prenatal counseling, reflective of patient-centered contraception counseling, that helped in their postpartum contraception decision-making; one woman described receiving immediate postpartum counseling that helped in her decision-making. Some Black women reported receiving unsupportive/coercive contraception counseling. In addition to contraception counseling, past reproductive health experiences and future pregnancy intentions were salient to women’s contraception decision-making.

Conclusions:

Prenatal and immediate postpartum contraception counseling can help some Medicaid beneficiaries with their postpartum contraception decision, but past reproductive health experiences and future pregnancy intentions are also relevant. Counseling that does not consider these experiences may be harmful, particularly to Black women, further contributing to racial disparities in maternal postpartum health outcomes.
What’s Up with Cultural Sociology? From Bourdieu and the Mainstream to ‘Productive Weirdness’
Authors: Thorpe Christopher , Inglis David
Published: September 2022

What constitutes the field of ‘cultural sociology’ today? Where has it come from, and where is it going? And how has the journal Cultural Sociology played a role in the field over the journal’s 15 years of existence? This article comprises a dialogue between one of the current editors, Christopher Thorpe, and one of the founding editors, David Inglis. Reflecting on these questions, the dialogue also touches on major issues in cultural sociology today; these include the continuing legacy of Bourdieu, the presence of Actor Network Theory, differences between critical-theoretical and Yale School conceptions of cultural autonomy, neo-liberalization processes, the status of postcolonial sociological ideas in the field, attempts to decolonize sociological accounts of culture, and the interplay between mainstream and ‘productively weird’ kinds of cultural sociology.
Functional hyperthermia caused by obstructive sleep apnea syndrome: A case report
Authors: Maita Hiroki , Kobayashi Tadashi , Akimoto Takashi , Osawa Hiroshi , Kato Hiroyuki
Published: September 2022

A 47-year-old farm worker with diabetes mellitus, dyslipidemia, and hyperuricemia was referred to our hospital for a 3-month history of fever and malaise. He had no respiratory tract or abdominal symptoms, skin rashes, or joint pain. There was no change to his regular medication or pesticide exposure. Blood tests and echocardiography revealed no abnormalities. Whole-body computed tomography revealed a fatty liver; however, non-alcoholic steatohepatitis was excluded. We diagnosed the patient with functional hyperthermia. He had a history of snoring and weight gain, and we suspected the obstructive sleep apnea syndrome to be a stressor. Polysomnography revealed severe obstructive sleep apnea syndrome with an apnea–hypopnea index of 44.5. Continuous positive airway pressure was introduced; the axillary temperature decreased gradually and malaise was resolved. Functional hyperthermia should be considered a cause of fever with a negative inflammatory response. Obstructive sleep apnea syndrome can be a stressor for functional hyperthermia, which can be improved by interventions.
Bipolar affective disorder in a patient with Fahr’s disease: The first recorded case in Bhutan
Authors: Chhetri Bikram , Gyeltshen Dawa , Letho Zimba
Published: September 2022

Fahr’s disease is a rare neurological disease that typically presents with neurological manifestations such as movement disorders. In a first recorded patient with Fahr’s disease in Bhutan, psychiatric diagnosis of bipolar affective disorder with current episode of severe depression was made, which is also a known manifestation of Fahr’s disease. Diagnosing a first case of Fahr’s disease is important for Bhutan because, though, it is a rare disease and it emphasizes the importance of recognizing other rare causes of psychiatric illness to tailor the treatment to the individual.
Does sports success increase government support? Voter (ir)rationality in a multiparty context
Authors: Rapeli Lauri , Söderlund Peter
Published: September 2022

A growing number of studies discuss the impact of non-political factors on the political success of incumbents. Theoretically, this literature addresses core ideas about electoral accountability and voter rationality. Scholars have explored factors such as shark attacks, weather, natural disasters, and sports results. So far, the evidence has been inconclusive and almost exclusively from majoritarian contexts, where government accountability is easy for voters to assign. We contribute with an analysis of whether nationally important sports success, such as Olympic gold medals, affect support for coalition governments in a multiparty context. We use monthly polling from Finland for a 28-year period from Jan 1994 to Dec 2021, which we combine with data on sports success. Our analysis shows that nationally important sports success has no impact on government popularity. The finding holds while controlling for traditional drivers of government popularity and across different operationalizations of government support and sports success. With this finding, the study joins several previous analyses, which have been supportive of voter rationality.
Participation incentives in a survey of international non-profit professionals
Authors: Safarpour Alauna , Bush Sarah Sunn , Hadden Jennifer
Published: September 2022

Elite surveys are increasingly common in political science, but how best to motivate participation in them remains poorly understood. This study compares the effect of three treatments designed to increase participation in an online survey of international non-profit professionals: a monetary reward, an altruistic appeal emphasizing the study’s benefits, and a promise to give the respondent access to the study’s results. Only the monetary incentive increased the survey response rate. It did not decrease response quality as measured in terms of straight-lining or skipped questions, although it may have produced a pool of respondents more likely to speed through the survey. The findings suggest that monetary incentives reduce total survey error even in the context of an elite survey, perhaps especially with elite populations frequently contacted by researchers. However, such incentives may not be without trade-offs in terms of how carefully respondents engage with the survey.
Fear, Political Legitimization, and Racism: Examining Anti-Asian Xenophobia During the COVID-19 Pandemic
Authors: Lantz Brendan , Wenger Marin R. , Mills Jack M.
Published: September 2022

Unfortunately, there is a long history linking pandemics to Anti-Asian prejudice and xenophobia; these negative outcomes have been particularly pronounced during the COVID-19 pandemic. Some scholars have suggested that these relationships are driven by fear, wherein individuals respond to disease threat by “othering” that threat. Other research has implicated the role of the state, including the political rhetoric of former President Trump, in exacerbating bias by enabling a divisive political environment. Yet, very few existing studies have been able to assess the nature of these impacts or examine the mechanisms behind observed increases in xenophobia. To that end, this research presents results from a survey administered in May 2020 to respondents residing in the U.S., which assessed COVID-19-related attitudes and behaviors, as well as anti-Asian prejudicial attitudes. Using these data, we assessed the direct and interactive relationship between perceptions of risk (i.e., fear), exposure to COVID-19 information, support for Trump, and anti-Asian prejudice. Results reveal that fear—and support for Trump—are associated with increased anti-Asian prejudice, but that exposure to more information about COVID-19 is associated with decreased prejudice; we also note complex interactions between each of these factors.
Does Compassion-Focused Therapy-Based Online Intervention Work for Chinese International Students With High Self-Criticism? A Randomized Controlled Trail
Authors: Gu Xinyu , Li Shasha , Hyun Myoung-Ho
Published: September 2022

Self-criticism represents a central phenomenon among a variety of psychological distress and has been shown to relate to the motivational systems of competing and social ranking. The purpose of our study was to test the effect of online compassion-focused therapy (CFT)-based intervention (CFI) on Chinese international students in South Korea suffering from high self-criticism and related psychological distress. Thirty-two Chinese international students with a high level of self-criticism were randomized to either a four-session CFI group, a four-session rational emotive behavior therapy (REBT)—based online self-help approach group, or a wait-list (WL) control group. The results suggest that the CFI group demonstrated significant improvements in self-criticism, compassion, depression, anxiety, and shame, and these were greater than those in the REBT and WL groups. Our work provides evidence that CFI offers a possible approach for reducing self-criticism and related psychological distress and increasing compassion level for young Chinese populations.
Recombinant Erwinia asparaginase (JZP458) in acute lymphoblastic leukemia: results from the phase 2/3 AALL1931 study
Authors: Maese Luke , Loh Mignon L. , Choi Mi Rim , Lin Tong , Aoki Etsuko , Zanette Michelle , Agarwal Shirali , Iannone Robert , Silverman Jeffrey A. , Silverman Lewis B. , Raetz Elizabeth A. , Rau Rachel E.
Published: September 2022

AALL1931, a phase 2/3 study conducted in collaboration with the Children’s Oncology Group, investigated the efficacy and safety of JZP458 (asparaginase erwinia chrysanthemi [recombinant]-rywn), a recombinant Erwinia asparaginase derived from a novel expression platform, in patients with acute lymphoblastic leukemia/lymphoblastic lymphoma who developed hypersensitivity/silent inactivation to Escherichia coli–derived asparaginases. Each dose of a pegylated E coli–derived asparaginase remaining in patients’ treatment plan was substituted by 6 doses of intramuscular (IM) JZP458 on Monday/Wednesday/Friday (MWF). Three regimens were evaluated: cohort 1a, 25 mg/m2 MWF; cohort 1b, 37.5 mg/m2 MWF; and cohort 1c, 25/25/50 mg/m2 MWF. Efficacy was evaluated by the proportion of patients maintaining adequate nadir serum asparaginase activity (NSAA ≥0.1 IU/mL) at 72 hours and at 48 hours during the first treatment course. A total of 167 patients were enrolled: cohort 1a (n = 33), cohort 1b (n = 83), and cohort 1c (n = 51). Mean serum asparaginase activity levels (IU/mL) at 72 hours were cohort 1a, 0.16, cohort 1b, 0.33, and cohort 1c, 0.47, and at 48 hours were 0.45, 0.88, and 0.66, respectively. The proportion of patients achieving NSAA ≥0.1 IU/mL at 72 and 48 hours in cohort 1c was 90% (44/49) and 96% (47/49), respectively. Simulated data from a population pharmacokinetic model matched the observed data well. Grade 3/4 treatment-related adverse events occurred in 86 of 167 (51%) patients; those leading to discontinuation included pancreatitis (6%), allergic reactions (5%), increased alanine aminotransferase (1%), and hyperammonemia (1%). Results demonstrate that IM JZP458 at 25/25/50 mg/m2 MWF is efficacious and has a safety profile consistent with other asparaginases. This trial was registered at www.clinicaltrials.gov as #NCT04145531.
Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome
Authors: Wang Xiao , Fan Jingyao , Guo Ruifeng , Hao Wen , Gong Wei , Yan Yan , Zheng Wen , Ai Hui , Que Bin , Hu Dan , Ma Changsheng , Ma Xinliang , Somers Virend K. , Nie Shaoping
Published: September 2022

Background

The impact of sex on the association of obstructive sleep apnoea (OSA) with recurrent cardiovascular events following acute coronary syndrome (ACS) remains uncertain. This study sought to examine the association between OSA and long-term cardiovascular outcomes in women and men with ACS.

Methods

In this prospective cohort study, we recruited 2160 ACS patients undergoing portable sleep monitoring between June 2015 and January 2020. The primary end-point was major adverse cardiovascular and cerebrovascular event (MACCE), including cardiovascular death, myocardial infarction, stroke, ischaemia-driven revascularisation or hospitalisation for unstable angina or heart failure.

Results

After exclusion of patients with failed sleep studies, central sleep apnoea, regular continuous positive airway pressure therapy and loss of follow-up, 1927 patients were enrolled. Among them, 298 (15.5%) were women and 1014 (52.6%) had OSA (apnoea–hypopnoea index ≥15 events·h−1). The prevalence of OSA was 43.0% and 54.4% in women and men, respectively. In 4339 person-years (median 2.9 years, interquartile range 1.5–3.6 years), the cumulative incidence of MACCE was significantly higher in OSAversusnon-OSA groups in the overall population (22.4%versus17.7%; adjusted hazard ratio (HR) 1.29, 95% CI 1.04–1.59; p=0.018). OSA was associated with greater risk of MACCE in women (28.1%versus18.8%; adjusted HR 1.68, 95% CI 1.02–2.78; p=0.042), but not in men (21.6%versus17.5%; adjusted HR 1.22, 95% CI 0.96–1.54; p=0.10). No significant interaction was noted between sex and OSA for MACCE (interaction p=0.32). The incremental risk in women was attributable to higher rates of hospitalisation for unstable angina and ischaemia-driven revascularisation.

Conclusions

In hospitalised ACS patients, OSA was associated with increased risk of subsequent events, particularly among women. Female patients with ACS should not be neglected for OSA screening and dedicated intervention studies focusing on women with ACS and comorbid OSA should be prioritised.
Structural diversity of natural cellulose and related applications using delignified wood
Authors: Horikawa Yoshiki
Published: September 2022

Cellulose is synthesized by organisms belonging to each biological kingdom, from bacteria to terrestrial plants, leading to its global-scale distribution. However, the structural properties of cellulose, such as its microfibril size, crystal form, cross-sectional shape, and uniplanar orientation, vary among species. This mini-review discusses the structural properties and diversity of cellulose. After describing historical developments in the structural analysis of cellulose, the technique of intracrystalline deuteration and rehydrogenation to understand structural diversity—particularly the localization of crystalline allomorphs in single microfibril—is discussed. Furthermore, the development of cellulose materials that maintain hierarchical structures of wood is introduced, and methods for producing functional materials are presented.
Effects of heat shock on photosynthesis-related characteristics and lipid profile of Cycas multipinnata and C. panzhihuaensis
Authors: Zhu Huan , Wu Yangyang , Zheng Yanling
Published: September 2022

Background

Cycas multipinnata and C. panzhihuaensis are two attractive ornamental tree species. With the global climate change, the temperature in the natural habitats of both the species shows a marked rising trend. However, how the two species respond to extreme high temperatures are not clear.

Chlorophyll fluorescence parameters, chlorophyll content, chloroplast ultrastructure and lipid metabolism in the two species were determined following plant exposure to heat stress.

Results

The results demonstrated that the photosynthetic efficiency decreased significantly in both the species following heat shock and recovery, but to a greater extent in C. panzhihuaensis. Compared to the control, chlorophyll content of C. multipinnata did not change significantly following heat stress and recovery. However, chlorophyll content of C. panzhihuaensis increased significantly after 1 d of recovery in comparison with the control. Chloroplast ultrastructures of C. panzhihuaensis were more severely affected by heat shock than C. multipinnata. C. multipinnata and C. panzhihuaensis followed a similar change trend in the amounts of most of the lipid categories after heat stress. However, only the amounts of lysophospholipids and fatty acyls differed significantly between the two species following heat treatment. Additionally, the unsaturation levels of the major lipid classes in C. multipinnata were significantly lower than or equal to those in C. panzhihuaensis.

Conclusions

C. multipinnata was less affected by extremely high temperatures than C. panzhihuaensis. The differential stability of chlorophyll and chloroplast ultrastructure and the differential adjustment of lipid metabolism might contribute to the different responses to heat shock between the two species.
Disparities in awareness of and willingness to participate in cancer clinical trials between African American and White cancer survivors
Authors: Kumar Gaurav , Kim Jungyoon , Farazi Paraskevi A. , Wang Hongmei , Su Dejun
Published: September 2022

Background

Cancer clinical trials (CCTs) are essential for cancer care, yet the evidence is scarce when it comes to racial disparities in CCT participation among cancer survivors in the Midwest. This study aimed to 1) assess disparities in the awareness of and willingness to participate in CCTs between African American and White cancer survivors; and 2) compare perceptions about CCTs between the two racial groups.

Methods

The study was based on cross-sectional data from the survey “Minority Patient Participation in Cancer Clinical Trials” that collected information from 147 Black and White cancer survivors from Nebraska between 2015 and 2016. Chi-square tests and logistic regressions were used to assess differences between Black and White cancer survivors regarding their awareness, willingness, and perceptions associated with CCT participation.

Results

After adjusting for the effects of socio-demographic, health status, and psychosocial variables, Black cancer survivors were much less likely than White cancer survivors to be aware of CCTs (AOR 0.26; CI 0.08–0.81), to express willingness to participate in CCTs (AOR 0.03; CI 0.01, 0.32) and to actually participate in CCTs (AOR 0.13; CI 0.04–0.38). Black cancer survivors reported a lower level of trust in physicians and were less likely than White cancer survivors to believe that CCTs make a significant contribution to science.

Conclusions

Relative to White cancer survivors, Black cancer survivors had much lower awareness of and willingness to participate in CCTs. Part of these differences might be related to the differential perception of CCTs, psychosocial factors, and trust in physicians between the two groups.
Blood pressure in children with sickle cell disease is higher than in the general pediatric population
Authors: Kupferman Juan C. , Rosenbaum Janet E. , Lande Marc B. , Stabouli Stella , Wang Yongsheng , Forman Daniella , Zafeiriou Dimitrios I. , Pavlakis Steven G.
Published: September 2022

Background

Sickle cell disease (SCD) is associated with an increased risk of cardiovascular disease that may be due to a variety of possible risk factors, including abnormal blood pressure. Blood pressure (BP) of children and adolescents with SCD has been reported to be lower compared to the BP of the general pediatric population.

Methods

To confirm this prior observation, we compared reference BP values for children with SCD with reference BP values of the general pediatric population. We hypothesized that children with SCD do not have lower BPs than children without SCD.

Results

Systolic BP differed for both males and females, over the different age groups between pediatric subjects with and without SCD. Systolic BP was higher in children with SCD, in both obese and non-obese populations. Diastolic BP did not differ between the groups.

Conclusions

Our analysis demonstrated that systolic BP values are indeed higher in children with SCD than in the general pediatric population. This finding is consistent with the most recent literature showing abnormal BP patterns in the SCD pediatric population utilizing 24-hour BP monitoring devices. This is an important step for recognizing abnormal BP as a risk factor for cardio- and neurovascular events in SCD.
An assessment of physician assistant student diversity in the United States: a snapshot for the healthcare workforce
Authors: Bradley-Guidry Carolyn , Burwell Nicole , Dorough Ramona , Bester Vanessa , Kayingo Gerald , Suzuki Sumihiro
Published: September 2022

Background

The Physician Assistant (PA) workforce falls short of mirroring national demographics mainly due to a lack of diversity in student enrollment. Few studies have systematically examined diversity across PA programs at the national level, and little is known about best practices for consistently graduating a diverse group of students. We descriptively characterized the extent to which PA programs are graduating a diverse group of students and identified top performing PA programs.

Methods

Data from the Integrated Postsecondary Education Data System (IPEDS) were used to calculate the number and proportion of racial or ethnically diverse graduates. The study sample included 139 accredited PA programs that had graduated a minimum of five cohorts from 2014–2018. Within each of the United States Census Divisions, programs were ranked according to the number and proportion of graduates who were underrepresented minority (URM) race, Hispanic ethnicity, and of non-white (URM race, Hispanic, and Asian).

Results

Amongst PA programs in the United States, a large disparity in the number and proportion of racial and ethnic graduates was observed. Of 34,625 PA graduates, only 2,207 (6.4%) were Hispanic ethnicity and 1,220 (3.5%) were URM race. Furthermore, a large number of diverse graduates came from a small number of top performing programs.

Conclusion

Despite the abundance of evidence for the need to diversify the healthcare workforce, PA programs have had difficulty recruiting and graduating a diverse group of students. This study provides empirical evidence that PA programs have not been able to attain the level of diversity necessary to shift the lack of diversity in the PA workforce. Based upon this study's findings, the top performing PA programs can be used as role models to establish benchmarks for other programs. The results of this descriptive study are currently being used to guide a qualitative study to identify the top performers’ strategies for success.
Entrepreneurial intention, expectations of success and self-efficacy in undergraduate students of health sciences
Authors: Romero-Galisteo Rita-Pilar , González-Sánchez Manuel , Gálvez-Ruiz Pablo , Palomo-Carrión Rocío , Casuso-Holgado Maria Jesus , Pinero-Pinto Elena
Published: September 2022

Background

Entrepreneurial intention is considered to be the best predictor of entrepreneurial behaviour. The Theory of Planned Behaviour (TPB) explains the degree of correlation between variables such as entrepreneurial intention, perceived feasibility and perceived desirability. Knowing the entrepreneurial intention of students of Health Sciences will help to guide and promote effective university policies to support entrepreneurship. The authors aimed to analyse the entrepreneurial intention of university students in the field of Health Sciences.

Methods

A cross-sectional study was conducted in the Faculties of Health Sciences of two public universities of Southern Spain. 1518 students of different degrees of Health Sciences (Physiotherapy, Podiatry, Dentistry, Nursing and Occupational Therapy), from first to fourth year. An online structured questionnaire was used, the Entrepreneurial Event Model (EEM) adapted to the Spanish context. This measurement model was completed with 8 items from the Motivated Strategies for Learning Questionnaire-MSLQ.

Results

The hypothetical model showed that perceived desirability and perceived feasibility were positive and significant predictors of entrepreneurial intention. Perceived desirability showed an indirect effect on entrepreneurial intention through perceived feasibility. Expectation of success and self-efficacy had no direct effect on entrepreneurial intention.

Conclusions

Perceived desirability and perceived feasibility are related to entrepreneurial intention in Health Sciences students.
The role of machine learning in developing non-magnetic resonance imaging based biomarkers for multiple sclerosis: a systematic review
Authors: Hossain Md Zakir , Daskalaki Elena , Brüstle Anne , Desborough Jane , Lueck Christian J. , Suominen Hanna
Published: September 2022

Background

Multiple sclerosis (MS) is a neurological condition whose symptoms, severity, and progression over time vary enormously among individuals. Ideally, each person living with MS should be provided with an accurate prognosis at the time of diagnosis, precision in initial and subsequent treatment decisions, and improved timeliness in detecting the need to reassess treatment regimens. To manage these three components, discovering an accurate, objective measure of overall disease severity is essential. Machine learning (ML) algorithms can contribute to finding such a clinically useful biomarker of MS through their ability to search and analyze datasets about potential biomarkers at scale. Our aim was to conduct a systematic review to determine how, and in what way, ML has been applied to the study of MS biomarkers on data from sources other than magnetic resonance imaging.

Methods

Systematic searches through eight databases were conducted for literature published in 2014–2020 on MS and specified ML algorithms.

Results

Of the 1, 052 returned papers, 66 met the inclusion criteria. All included papers addressed developing classifiers for MS identification or measuring its progression, typically, using hold-out evaluation on subsets of fewer than 200 participants with MS. These classifiers focused on biomarkers of MS, ranging from those derived from omics and phenotypical data (34.5% clinical, 33.3% biological, 23.0% physiological, and 9.2% drug response). Algorithmic choices were dependent on both the amount of data available for supervised ML (91.5%; 49.2% classification and 42.3% regression) and the requirement to be able to justify the resulting decision-making principles in healthcare settings. Therefore, algorithms based on decision trees and support vector machines were commonly used, and the maximum average performance of 89.9% AUC was found in random forests comparing with other ML algorithms.

Conclusions

ML is applicable to determining how candidate biomarkers perform in the assessment of disease severity. However, applying ML research to develop decision aids to help clinicians optimize treatment strategies and analyze treatment responses in individual patients calls for creating appropriate data resources and shared experimental protocols. They should target proceeding from segregated classification of signals or natural language to both holistic analyses across data modalities and clinically-meaningful differentiation of disease.
Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis
Authors: Shih Andrew J. , Adelson Robert P. , Vashistha Himanshu , Khalili Houman , Nayyar Ashima , Puran Radha , Herrera Rixsi , Chatterjee Prodyot K. , Lee Annette T. , Truskinovsky Alexander M. , Elmaliki Kristine , DeFranco Margaret , Metz Christine N. , Gregersen Peter K.
Published: September 2022

Background

Endometriosis is a common, complex disorder which is underrecognized and subject to prolonged delays in diagnosis. It is accompanied by significant changes in the eutopic endometrial lining.

Methods

We have undertaken the first single-cell RNA-sequencing (scRNA-Seq) comparison of endometrial tissues in freshly collected menstrual effluent (ME) from 33 subjects, including confirmed endometriosis patients (cases) and controls as well as symptomatic subjects (who have chronic symptoms suggestive of endometriosis but have not been diagnosed).

Results

We identify a unique subcluster of proliferating uterine natural killer (uNK) cells in ME-tissues from controls that is almost absent from endometriosis cases, along with a striking reduction of total uNK cells in the ME of cases (p < 10−16). In addition, an IGFBP1+ decidualized subset of endometrial stromal cells are abundant in the shed endometrium of controls when compared to cases (p < 10−16) confirming findings of compromised decidualization of cultured stromal cells from cases. By contrast, endometrial stromal cells from cases are enriched in cells expressing pro-inflammatory and senescent phenotypes. An enrichment of B cells in the cases (p = 5.8 × 10−6) raises the possibility that some may have chronic endometritis, a disorder which predisposes to endometriosis.

Conclusions

We propose that characterization of endometrial tissues in ME will provide an effective screening tool for identifying endometriosis in patients with chronic symptoms suggestive of this disorder. This constitutes a major advance, since delayed diagnosis for many years is a major clinical problem in the evaluation of these patients. Comprehensive analysis of ME is expected to lead to new diagnostic and therapeutic approaches to endometriosis and other associated reproductive disorders such as female infertility.
CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
Authors: Chang Ting-Ting , Chen Ching , Chen Jaw-Wen
Published: September 2022

Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further amplify inflammatory processes and contribute to disease progression. However, CCL7-specific pathological signaling pathways need to be further confirmed in these chronic diseases. Given the multiple redundancy system among chemokines and their receptors, further experimental and clinical studies are needed to clarify whether direct CCL7 inhibition mechanisms could be a promising therapeutic approach to attenuating the development of cardiovascular disease, diabetes mellitus, and kidney disease.
Recent advances and limitations of mTOR inhibitors in the treatment of cancer
Authors: Ali Eunus S. , Mitra Kangkana , Akter Shamima , Ramproshad Sarker , Mondal Banani , Khan Ishaq N. , Islam Muhammad Torequl , Sharifi-Rad Javad , Calina Daniela , Cho William C.
Published: September 2022

The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers.
Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes
Authors: Xia Jiaxuan , Zhang Shuya , Zhang Ru , Wang Anni , Zhu Ying , Dong Meichen , Ma Shaojie , Hong Chao , Liu Shengyao , Wang Dan , Wang Jianxin
Published: September 2022

The chemotherapy effect of docetaxel (DTX) against triple-negative breast cancer (TNBC) remains mediocre and limited when encapsulated in conventional cholesterol liposomes, mainly ascribed to poor penetration and immunosuppressive tumor microenvironment (TME) caused by tumor stroma cells, especially cancer-associated fibroblasts (CAFs). Many studies have attempted to address these problems but trapped into the common dilemma of excessively complicated formulation strategies at the expense of druggability as well as clinical translational feasibility. To better address the discrepancy, ginsenoside Rg3 was utilized to substitute cholesterol to develop a multifunctional DTX-loaded Rg3 liposome (Rg3-Lp/DTX). The obtained Rg3-Lp/DTX was proved to be preferentially uptake by 4T1 cells and accumulate more at tumor site via the interaction between the glycosyl moiety of Rg3 exposed on liposome surface and glucose transporter1 (Glut1) overexpressed on tumor cells. After reaching tumor site, Rg3 was shown to reverse the activated CAFs to the resting stage and attenuate the dense stroma barrier by suppressing secretion of TGF-β from tumor cells and regulating TGF-β/Smad signaling. Therefore, reduced levels of CAFs and collagens were found in TME after incorporation of Rg3, inducing enhanced penetration of Rg3-Lp/DTX in the tumor and reversed immune system which can detect and neutralize tumor cells. Compared with wooden cholesterol liposomes, the smart and versatile Rg3-Lp/DTX could significantly improve the anti-tumor effect of DTX, providing a promising approach for TNBC therapy with excellent therapeutic efficacy and simple preparation process.
Is bone marrow oedema in patients with labral tear an indicator of hip pain?
Authors: Koyama Tomohisa , Fukushima Kensuke , Uchida Kentaro , Ohashi Yoshihisa , Uchiyama Katsufumi , Takahira Naonobu , Takaso Masashi
Published: September 2022

Background

Hip labral tear (LT) causes various degrees of hip pain, for which there are few objective measures. Bone marrow oedema (BME), characterized by a diffuse, widely spreading change in the bone marrow, is observed in some patients with LT. However, its pathological role has not been fully understood. The purpose of this study was to investigate the prevalence of BME on hip magnetic resonance imaging (MRI) in patients with LT and to determine whether BME was an objective indicator of hip pain.

Methods

In total, 84 patients with LT who underwent MRI scanning under the same conditions were included. We determined the presence or absence of BME and its size on MRI and evaluated the relationships between BME and sex, age, and pain and total scores on the modified Harris hip score (MHHS). In addition, we collected data on surgical treatments such as hip arthroscopy within a one-year follow-up period and examined whether the presence of BME affected the course of therapy.

Results

BME was found in 34.5% of patients. MHHS pain and total scores were significantly lower in patients with BME (MHHS pain score: non-BME vs. BME ≤ 1 cm: p = 0.022, non-BME vs. BME > 1 cm: p < 0.001; MHHS total score: non-BME vs. BME ≤ 1 cm: p = 0.131, non-BME vs. BME > 1 cm: p = 0.027). The presence of BME did not differ between patients who did and did not undergo surgery during follow-up (p = 0.563).

Conclusion

BME on MRI in patients with LT might be an indicator of hip pain and hip joint dysfunction.
Increased behavioral problems in children with sleep-disordered breathing
Authors: Csábi Eszter , Gaál Veronika , Hallgató Emese , Schulcz Rebeka Anna , Katona Gábor , Benedek Pálma
Published: September 2022

Background

Healthy sleep is essential for the cognitive, behavioral and emotional development of children. Therefore, this study aimed to assess the behavioral consequences of sleep disturbances by examining children with sleep-disordered breathing compared with control participants.

Methods

Seventy-eight children with SDB (average age: 6.7 years (SD = 1.83); 61 had OSA and 17 had primary snoring) and 156 control subjects (average age: 6.57 years (SD = 1.46) participated in the study. We matched the groups in age (t(232) = 0.578, p = 0.564) and gender (χ2(1) = 2.192, p = 0.139). In the SDB group, the average Apnea–Hypopnea Index was 3.44 event/h (SD = 4.00), the average desaturation level was 87.37% (SD = 6.91). Parent-report rating scales were used to measure the children’s daytime behavior including Attention Deficit Hyperactivity Disorder Rating Scale, Strengths and Difficulties Questionnaire, and Child Behavior Checklist.

Results

Our results showed that children with SDB exhibited a higher level of inattentiveness and hyperactive behavior. Furthermore, the SDB group demonstrated more internalizing (anxiety, depression, somatic complaints, social problems) (p < 0.001) and externalizing (aggressive and rule-breaking behavior) problems compared with children without SDB, irrespective of severity.

Conclusions

Based on our findings we supposed that snoring and mild OSA had a risk for developing behavioral and emotional dysfunctions as much as moderate-severe OSA. Therefore, clinical research and practice need to focus more on the accurate assessment and treatment of sleep disturbances in childhood, particularly primary snoring, and mild obstructive sleep apnea.