bluuebunny/crossref_metadata_2025 huggingface dataset:
Disentangling the Intelligentization–Carbon Emission Nexus within China’s Logistics Sector: An Econometric Approach
Authors: Jiao Zhilun , Yu Ningning , Wu Xiaofan
Published: August 2024

Amidst the global pursuit of environmental sustainability, the concurrent trends of decarbonization and intelligentization have emerged as critical strategic priorities. However, the interplay between these phenomena, particularly within the logistics sector, remains an underexplored area. This study investigates the complex dynamics between logistics intelligentization and decarbonization across 29 provinces in China from 2006 to 2019, providing a fresh perspective on a globally relevant issue. By employing Differential GMM, Systematic GMM, and instrumental variable-based GMM models, we evaluate the impact of logistics intelligence on carbon emissions while effectively addressing endogeneity issues inherent in the empirical analysis. Our findings reveal that the advancement of intelligent logistics correlates positively with increased carbon emissions, highlighting a significant incompatibility between decarbonization objectives and intelligentization efforts within the logistics sector. Additionally, we identify mediating pathways—specifically scale, structure, and technology effects—and moderating mechanisms that influence this relationship. These insights underscore the need for policymakers to establish environmental standards for intelligent technology adoption and to promote initiatives that reconcile intelligentization with sustainability goals. Ultimately, our study provides critical guidance for promoting sustainable and smart industrial growth in the logistics sector.
A Comprehensive Experimental Investigation of NOx Emission Characteristics in Hydrogen Engine Using an Ultra-Fast Crank Domain Measurement
Authors: Mohamed Mohamed , Wang Xinyan , Zhao Hua , Peckham Mark , Hall Jonathan , Jiang Changzhao
Published: August 2024

Adopting zero-carbon fuels, like hydrogen, can significantly reduce environmental harm and pave the way for a decarbonised trajectory with zero carbon emissions. The hydrogen internal combustion engine (ICE) technology has demonstrated its reliability and capacity to seamlessly integrate into the current ICE platform, originally designed for diesel and gasoline operation. The direct utilisation of pure hydrogen eradicates steady-state carbon dioxide and hydrocarbon emissions. It is important to highlight that efforts to comprehend and comprehensively tackle NOx emissions are underway. A comprehensive study was carried out to assess the NOx emissions for a hydrogen ICE with different injection modes from gasoline. The study involved varying the relative air-to-fuel ratio (AFR) from stoichiometric to the lean-burn limit in a boosted spark ignition (SI) engine fuelled with gasoline or hydrogen. A fast NOx emissions analyser was employed to measure the instantaneous NO and NO2 emissions in the engine exhaust. The study provides a detailed analysis of NOx emissions, including steady-state averaged emissions, average crank angle domain NOx distribution and emissions, in-cylinder pressure analysis, as well as time and cycle analyses of NOx emissions’ temporal and cyclic variations. The primary discovery was that NOx emissions are almost zero between lambda 2.75 and 3.7, and hydrogen produces 13.8% less NOx emissions than gasoline at stoichiometric operation. Finally, the full NOx time analysis revealed that the consistency of NOx emissions is higher with hydrogen than with gasoline by using a novel approach by identifying the coefficient of variation of the NOx emission of each cycle.
Nickel and Soil Fertility: Review of Benefits to Environment and Food Security
Authors: Rabinovich Alon , Di Rong , Lindert Sean , Heckman Joseph
Published: August 2024

Nickel (Ni) is an essential micronutrient for plants, responsible for metabolizing urea nitrogen (urea-N) by urease and mitigating abiotic and oxidative stresses through the glyoxalase (Gly) and glutathione (GSH) cycles. However, excess Ni is toxic to flora at >100 mg kg−1, except for hyperaccumulators that tolerate >1000 mg kg−1 Ni. This review discusses the benefits of Ni nutrient management for soil fertility, improving food security, and minimizing adverse environmental impacts from urea overapplication. Many farming soils are Ni deficient, suggesting that applying 0.05–5 kg ha−1 of Ni improves yield and urea-N use efficiency. Applied foliar and soil Ni fertilizers decrease biotic stresses primarily by control of fungal diseases. The bioavailability of Ni is the limiting factor for urease synthesis in plants, animal guts, and the soil microbiome. Improved urease activity in plants and subsequently through feed in livestock guts reduces the release of nitrous oxide and nitrite pollutants. Fertilizer Ni applied to crops is dispersed in vegetative tissue since Ni is highly mobile in plants and is not accumulated in fruit or leafy tissues to cause health concerns for consumers. New methods for micronutrient delivery, including rhizophagy, recycled struvite, and nanoparticle fertilizers, can improve Ni bioavailability in farming systems.
Chromosome-Level Genome Assembly and Comparative Genomic Analysis of the Barbel Chub (Squaliobarbus curriculus) by Integration of PacBio Sequencing and Hi-C Technology
Authors: Zhang Baidong , Sun Yanling , Liu Yang , Song Xiaojun , Wang Su , Xiao Tiaoyi , Nie Pin
Published: August 2024

The barbel chub (Squaliobarbus curriculus), the only species in the genus, is widely distributed in freshwater lakes and rivers at different latitudes in East Asia, with fishery and biodiversity importance, and is an emerging commercially important fish in China. However, the resource of this species has dramatically declined due to anthropogenic activities such as over-exploitation, as well as water pollution. Genomic resources for S. curriculus are useful for the management and sustainable utilization of this important fish species, and also for a better understanding of its genetic variation in the region. Here, we report the chromosome-level assembly of the S. curriculus genome obtained from the integration of PacBio long sequencing and Hi-C technology. A total of 155.34 Gb high-quality PacBio sequences were generated, and the preliminary genome assembly was 894.95 Mb in size with a contig N50 being 20.34 Mb. By using Hi-C data, 99.42% of the assembled sequences were anchored to 24 pseudochromosomes, with chromosome lengths ranging from 27.22 to 58.75 Mb. A total of 25,779 protein-coding genes were predicted, 94.70% of which were functionally annotated. Moreover, S. curriculus shows resistance to grass carp haemorrhagic disease (GCHD) caused by grass carp reovirus (GCRV), which seriously hinders the status and future perspectives of commercial grass carp production. Phylogenetic analysis indicated that S. curriculus diverged with grass carp (Ctenopharyngodon idellus) approximately 20.80 million years ago. Annotations of the expanded gene families were found to be largely enriched in immune-related KEGG pathway categories. Moreover, a total of 18 Toll-like receptor (TLR) genes were identified from the whole genome of S. curriculus. The high-quality genome assembled in this study will provide a valuable resource for accelerating ecological, evolutionary, and genetic research on S. curriculus.
Numerical Analysis of the Submerged Horizontal Plate Device Subjected to Representative Regular and Realistic Irregular Waves of a Sea State
Authors: Thum Gabrielle Ücker , Maciel Rafael Pereira , Oleinik Phelype Haron , Rocha Luiz Alberto Oliveira , dos Santos Elizaldo Domingues , Seibt Flavio Medeiros , Machado Bianca Neves , Isoldi Liércio André
Published: August 2024

This study numerically analyzes a submerged horizontal plate (SHP) device subjected to both regular and irregular waves. This device can be used either as a breakwater or a wave energy converter (WEC). The WaveMIMO methodology was applied for the numerical generation and wave propagation of the sea state of the Rio Grande coast in southern Brazil. The finite volume method was employed to solve conservation equations for mass, momentum, and volume fraction transport. The volume of fluid model was employed to handle the water-air mixture. The SHP length (Lp) effects were carried out in five cases. Results indicate that relying solely on regular waves in numerical studies is insufficient for accurately determining the real hydrodynamic behavior. The efficiency of the SHP as a breakwater and WEC varied depending on the wave approach. Specifically, the SHP demonstrates its highest breakwater efficiency in reducing wave height at 2.5Lp for regular waves and 3Lp for irregular waves. As a WEC, it achieves its highest axial velocity at 3Lp for regular waves and 2Lp for irregular waves. Since the literature lacks studies on SHP devices under the incidence of realistic irregular waves, this study significantly contributes to the state of the art.
Consumer Perception of Food Safety and Valuation of Statistical Life: A Contingent Valuation Study
Authors: Liu Bingjie , Na Yinuo , Li Yi , Wang Dan , Zhang Xin
Published: August 2024

The value of statistical life (VSL) reflects the trade-off between money and the risk of death. It is a key indicator for conducting regulatory impact assessments. The main purpose of this study was to estimate the VSL in the field of food safety. At the same time, it investigates respondents’ willingness to pay (WTP) for reducing the risk of death from foodborne illnesses and explores the impact of factors such as the average household monthly income, health status, and education level on WTP. We conducted a survey using an open-ended contingent valuation method among 1307 respondents aged 18 and above to determine their WTP. Based on the WTP survey results, we calculated the VSL in the food safety sector. We used binary logit and Tobit models to analyze the influencing factors. The results of the study show that the median WTP for reducing the risk of foodborne illness is CNY 100 (USD 16), and the estimated VSL is approximately CNY 9.09 million (USD 141 million). Indicators such as the average household monthly income, health status, and education level are important factors affecting WTP. This study will help practitioners, researchers, and policymakers understand the current population’s attitudes towards food safety regulations and determine the priorities for regulatory implementation. Future research can explore the effects of different elicitation methods, cultural differences, and regional variations on WTP and VSL.
How Cognition Influences Chinese Residents’ Continuous Purchasing Intention of Prepared Dishes under the Distributed Cognitive Perspective
Authors: Fu Yuelin , Zhang Weihua , Wang Ranran , Zheng Jiaqiang
Published: August 2024

Enhancing residents’ purchasing intention of prepared dishes is crucial for the sustainable development of the prepared dishes industry. Understanding how residents’ cognition influences their continuous purchasing intention can provide valuable insight for developing and refining company strategies, thereby reducing industry development obstacles. Based on the theory of distributed cognition, this study utilizes questionnaire data from urban residents in Beijing and Shanghai, and employs Structural Equation Modeling to explore the influence of cognition on the continuous purchasing intention of Chinese urban residents towards prepared dishes. The study results reveal that: (1) Individual power and geographical power have a significant positive effect on residents’ continuous purchasing intention for prepared dishes, while cultural power does not have a significant effect. (2) Risk perception partially mediates the effect of individual power and geographical power on continuous purchasing intention and fully mediates the effect of cultural power on continuous purchasing intention. Recommendations include: (1) The government should enhance standardization and supervision to create a favorable consumption environment; (2) Enterprises should provide more objective and transparent information to improve residents’ knowledge of prepared dishes and establish a good reputation.
Influence of the Crystal Forms of Calcium Carbonate on the Preparation and Characteristics of Indigo Carmine-Calcium Carbonate Lake
Authors: Jing Le , Liu Yuhan , Cui Jiaqi , Ma Jinghan , Yuan Dongdong , Wang Chengtao
Published: August 2024

In this study, indigo carmine (IC)-calcium carbonate lakes with different crystalline forms of calcium carbonate were prepared through co-precipitation methods, and the properties of these lakes and their formation mechanisms were investigated. The results showed that amorphous calcium carbonate (ACC) exhibited the smallest particle size and the largest specific surface area, resulting in the highest adsorption efficiency. Vaterite, calcite, and aragonite followed after ACC in decreasing order of adsorption efficiency. Kinetic analysis and isothermal analysis revealed the occurrence of chemisorption and multilayer adsorption during formation of the lakes. The FTIR and Raman spectra suggested participation of sulfonic acid groups in chemisorption. Appearance of IC significantly altered TGA curves by changing weight loss rate before decomposition of calcium carbonate. EDS analysis revealed the adsorption of IC predominantly happened on the surface of calcium carbonate particles rather than the interior.
The Effect of One-Year Fermentation of Maesil Fruit (Prunus mume) Sugar Syrup on Amygdalin Level: A Natural Toxic Compound
Authors: Ramalingam Srinivasan , Kumar Vishal , Bahuguna Ashutosh , Lee Jong Suk , Kim Myunghee
Published: August 2024

Prunus mume (maesil) is an economically important fruit in Korea. Recently, public interest in maesil sugar syrup is increasing. However, the presence of toxic amygdalin in the fruit syrup is a concern. Thus, the current investigation aimed to observe effects of maesil maturity, ripening methods, processing, and fermentation period on the amygdalin level in maesil sugar syrup. Six different types of maesil sugar syrup were prepared and amygdalin content was monitored at 3-month intervals. Higher levels (>63 mg/L) of amygdalin were found in syrups prepared from unripe fruit compared to those in syrups made from ripe fruit after 3 months of fermentation. A rapid reduction in amygdalin content was observed until 9 months in all syrups, gradually reducing to <5 mg/L at 12 months. More than 9 months of maturation is crucial for reducing the amygdalin content maesil sugar syrup, regardless of fruit maturity, source of fruit, and processing method.
Effects of Bergamot (Citrus bergamia Risso) By-Product on Growth Performance and Meat Quality of Growing Rabbits
Authors: Scerra Manuel , Foti Francesco , Caparra Pasquale , Bognanno Matteo , Fortugno Paolo , Autolitano Domenico , Viglianti Domenico , Bella Marco Sebastiano , Cannone Marco Sebastiano , Chies Luigi
Published: August 2024

This study aimed to investigate the effects of feeding dried bergamot pulp to rabbits on animal performance and meat quality. Thirty rabbits were assigned to two groups (balanced for body weight, 804.4 ± 2.35 g) and fed individually for 60 days a basal diet (control) or the basal diet in which part of the cereals was replaced with 10% of dried bergamot pulp (DBP). There were no effects of DBP on growth performance, carcass yield, or the crude protein and ether extract composition of meat. The concentrations of α-linolenic acid (C18:3 n-3) and eicosapentaenoic acid (C20:5 n-3) increased in the longissimus thoracis et lumborum muscle (p < 0.01 and p = 0.021, respectively) after integrating dried bergamot pulp into the diet, leading to higher levels of total of ω-3 fatty acids (p < 0.01) compared to the control treatment. The inclusion of dried bergamot pulp improved the oxidative stability in meat (p < 0.001), where TBARS values were lower after 4 and 7 days of refrigerated storage (p < 0.001) in the DBP group than in the control group. Finally, feeding dried bergamot pulp to rabbits improves meat quality without negatively influencing growth performance.
Logging Evaluation of Irreducible Water Saturation: Fractal Theory and Data-Driven Approach—Case Study of Complex Porous Carbonate Reservoirs in Mishrif Formation
Authors: Guo Jianhong , Zhang Zhansong , Nie Xin , Zhao Qing , Lv Hengyang
Published: August 2024

Evaluating irreducible water saturation is crucial for estimating reservoir capacity and developing effective extraction strategies. Traditional methods for predicting irreducible water saturation are limited by their reliance on specific logging data, which affects accuracy and applicability. This study introduces a predictive method based on fractal theory and deep learning for assessing irreducible water saturation in complex carbonate reservoirs. Utilizing the Mishrif Formation of the Halfaya oilfield as a case study, a new evaluation model was developed using the nuclear magnetic resonance (NMR) fractal permeability model and validated with surface NMR and mercury injection capillary pressure (MICP) data. The relationship between the logarithm mean of the transverse relaxation time (T2lm) and physical properties was explored through fractal theory and the Thomeer Function. This relationship was integrated with conventional logging curves and an advanced deep learning algorithm to construct a T2lm prediction model, offering a robust data foundation for irreducible water saturation evaluation. The results show that the new method is applicable to wells with and without specialized NMR logging data. For the Mishrif Formation, the predicted irreducible water saturation achieved a coefficient of determination of 0.943 compared to core results, with a mean absolute error of 2.37% and a mean relative error of 8.46%. Despite introducing additional errors with inverted T2lm curves, it remains within acceptable limits. Compared to traditional methods, this approach provides enhanced predictive accuracy and broader applicability.
Applying Different Conditions in the OphthalMimic Device Using Polymeric and Hydrogel-Based Hybrid Membranes to Evaluate Gels and Nanostructured Ophthalmic Formulations
Authors: Contarato Jonad L. A. , Barbalho Geisa N. , Cunha-Filho Marcilio , Gelfuso Guilherme M. , Gratieri Tais
Published: August 2024

The OphthalMimic is a 3D-printed device that simulates human ocular conditions with artificial lacrimal flow, cul-de-sac area, moving eyelid, and a surface to interact with ophthalmic formulations. All tests with such a device have used a continuous artificial tear flow rate of 1 mL/min for 5 min. Here, we implemented protocol variations regarding the application time and simulated tear flow to increase the test’s discrimination and achieve reliable performance results. The new protocols incorporated the previously evaluated 0.2% fluconazole formulations containing or not chitosan as a mucoadhesive component (PLX16CS10 and PLX16, respectively) and novel moxifloxacin 5% formulations, either in a conventional formulation and a microemulsion (CONTROL and NEMOX, respectively). The flow rate was reduced by 50%, and a pre-flow application period was also included to allow formulation interaction with the membrane. The OphthalMimic model was used with both polymeric and hydrogel-based hybrid membranes, including a simulated eyelid. Lowering the flow made it feasible to prolong the testing duration, enhancing device discrimination potential. The hydrogel membrane was adequate for testing nanostructure formulations. The OphthalMimic device demonstrated once again to be a versatile method for evaluating the performance of ophthalmic drug formulations with the potential of reducing the use of animals for experimentation.
Development of Valid and Reliable Questionnaire to Evaluate Knowledge, Attitude, and Practices (KAP) of Lifestyle Medicine Domains
Authors: Alzaben Abeer Salman , Almansour Mohammed , Alzahrani Hayat Saleh , Alrumaihi Nouf Adnan , Alhamedi Nesrain Mubarak , Albuhayjan Nawaf Abdulaziz , Aljammaz Sadeem Abdulaziz
Published: August 2024

Lifestyle medicine (LM) should be incorporated as part of routine clinical work and medical education programs. Objective: To develop and test the validity and reliability of a questionnaire that measures the level of knowledge, attitude, and practice (KAP) of LM domains among medical trainees through practicing physicians. Methods: The KAP questionnaire sections covered the nine domains of LM. The validation process included face and content validity. A total of 151 individuals from the medical field residing in Saudi Arabia were recruited through a convenient sampling technique to participate in the study. Item response theory (IRT) was applied to validate the knowledge domain, while exploratory factor analysis (EFA) was used to assess attitude and practice. Cronbach’s alpha was performed to test the reliability of the three sections. Results: The questionnaire contained 37 items of knowledge, 45 attitudes, and 28 practice items. According to the IRT analysis, 27 items of knowledge were within the acceptable range of difficulty and discrimination. The EFA analysis resulted in 6 factors, including all the items in the attitude domain, and 4 factors, for a total of 27 items in the practice domain, with satisfactory factor loading (>0.4). The Cronbach’s alpha for the three domains was very high (≥0.88). Conclusions: The KAP questionnaire for LM is valid and reliable across a spectrum, from medical trainees to practicing physicians. This tool could serve as an instrument to evaluate and develop adequate educational programs for medical doctors.
Public and Patient Involvement in Migration Health Research: Eritrean and Syrian Refugees’ and Asylum Seekers’ Views in Switzerland
Authors: Chernet Afona , Paris Daniel H. , Alchalabi Lujain , Utzinger Jürg , Reus Elisabeth
Published: August 2024

Prior research has highlighted important healthcare access and utilization issues among new forced immigrants. We aimed to explore the role that public and patient involvement (PPI) might play in enhancing accessibility and specific contributions to migration health studies. We conducted open and in-depth interactive virtual discussions with asylum seekers and refugees from Eritrea and Syria in Switzerland. The PPI establishment consisted of three phases: inception, training and contribution. Prior to training, the concept of PPI was not straightforward to grasp, as it was a new approach—however, after training and consecutive discussions, participants were ardent to engage actively. We conclude that PPI holds promise in regard to raising awareness, improving healthcare system accessibilities and utilization, and enhancing and strengthening migration health research. Indeed, PPI volunteers were keen to raise their community’s awareness through their networks and bridge an important gap between researchers and the public.
Impact of Social Needs and Identity Experiences on the Burden of Illness in Patients with Multiple Myeloma: A Mixed-Methods Study
Authors: Neparidze Natalia , Godara Amandeep , Lin Dee , Le Hoa H. , Fixler Karen , Shea Lisa , Everson Stephanie , Brittle Christine , Brunisholz Kimberly D.
Published: August 2024

Multiple myeloma (MM) is a common hematologic malignancy, but due to its incurable nature, patients experience many relapses in their lifetime and hence face unique challenges. This mixed-methods study consisting of an online survey and subsequent focus groups aimed to understand how social and identity experiences affected the diagnostic, treatment, and care journey for patients with MM. Twenty-three adult patients with MM participated in this study. The survey participants identified common determinants negatively impacting their health, including mental health concerns (experienced by 90.5% of respondents), worries about food shortage (42.9%), and transportation concerns (28.6%). Focus group participants described high physical and mental health burdens associated with MM. Frequent monitoring, fear of a relapse, and unpredictable side effects contributed to high anxiety. Participants indicated that MM differed from other types of cancer and chronic health conditions in many ways, particularly how and where the diagnosis was made, disease progression and relapse, treatments and side effects, and financial concerns. Most participants (65.0%) reported ≥1 social need that negatively impacted health outcomes including lack of knowledge about MM, financial instability, and lack of insurance, transportation, and social support. The findings reveal that patients with MM continually experience patient-specific mental and physical health burdens indicating high unmet needs throughout the disease journey.
KMT2A Rearrangements in Leukemias: Molecular Aspects and Therapeutic Perspectives
Authors: Guarnera Luca , D’Addona Matteo , Bravo-Perez Carlos , Visconte Valeria
Published: August 2024

KMT2A (alias: mixed-lineage leukemia [MLL]) gene mapping on chromosome 11q23 encodes the lysine-specific histone N-methyltransferase 2A and promotes transcription by inducing an open chromatin conformation. Numerous genomic breakpoints within the KMT2A gene have been reported in young children and adults with hematologic disorders and are present in up to 10% of acute leukemias. These rearrangements describe distinct features and worse prognosis depending on the fusion partner, characterized by chemotherapy resistance and high rates of relapse, with a progression-free survival of 30–40% and overall survival below 25%. Less intensive regimens are used in pediatric patients, while new combination therapies and targeted immunotherapeutic agents are being explored in adults. Beneficial therapeutic effects, and even cure, can be reached with hematopoietic stem cell transplantation, mainly in young children with dismal molecular lesions; however, delayed related toxicities represent a concern. Herein, we summarize the translocation partner genes and partial tandem duplications of the KMT2A gene, their molecular impact, clinical aspects, and novel targeted therapies.
Leveraging PARP-1/2 to Target Distant Metastasis
Authors: Frederick Mallory I. , Abdesselam Djihane , Clouvel Anna , Croteau Laurent , Hassan Saima
Published: August 2024

Poly (ADP-Ribose) Polymerase (PARP) inhibitors have changed the outcomes and therapeutic strategy for several cancer types. As a targeted therapeutic mainly for patients with BRCA1/2 mutations, PARP inhibitors have commonly been exploited for their capacity to prevent DNA repair. In this review, we discuss the multifaceted roles of PARP-1 and PARP-2 beyond DNA repair, including the impact of PARP-1 on chemokine signalling, immune modulation, and transcriptional regulation of gene expression, particularly in the contexts of angiogenesis and epithelial-to-mesenchymal transition (EMT). We evaluate the pre-clinical role of PARP inhibitors, either as single-agent or combination therapies, to block the metastatic process. Efficacy of PARP inhibitors was demonstrated via DNA repair-dependent and independent mechanisms, including DNA damage, cell migration, invasion, initial colonization at the metastatic site, osteoclastogenesis, and micrometastasis formation. Finally, we summarize the recent clinical advancements of PARP inhibitors in the prevention and progression of distant metastases, with a particular focus on specific metastatic sites and PARP-1 selective inhibitors. Overall, PARP inhibitors have demonstrated great potential in inhibiting the metastatic process, pointing the way for greater use in early cancer settings.
Effects of Sequential Induction Combining Thermal Treatment with Ultrasound or High Hydrostatic Pressure on the Physicochemical and Mechanical Properties of Pea Protein–Psyllium Hydrogels as Elderberry Extract Carriers
Authors: Hilal Adonis , Florowska Anna , Florowski Tomasz , Rybak Katarzyna , Domian Ewa , Szymański Marcin , Wroniak Małgorzata
Published: August 2024

Entrapping bioactive ingredients like elderberry extract in hydrogels improves their stability and functionality in food matrices. This study assessed the effect of sequential thermal treatment with ultrasound (US) or high hydrostatic pressure (HHP) and treatment duration on pea protein–psyllium hydrogels as elderberry extract carriers. Measurements included color parameters, extract entrapment efficiency, physical stability, textural properties, microrheology, FT-IR, thermal degradation (TGA), SEM images, total polyphenols content, antioxidant activity, and reducing power. The control hydrogel was obtained using only thermal induction. Both treatments impacted physical stability by affecting biopolymer aggregate structures. Thermal and US combined induction resulted in hydrogels with noticeable color changes and reduced entrapment efficiency. Conversely, thermal and HHP-combined induction, especially with extended secondary treatment (10 min), enhanced hydrogel strength, uniformity, and extract entrapment efficiency (EE = 33% for P10). FT-IR and TGA indicated no chemical structural alterations post-treatment. Sequential thermal and HHP induction preserved polyphenol content, antioxidant activity (ABTS = 5.8 mg TE/g d.m.; DPPH = 11.1 mg TE/g d.m.), and reducing power (RP = 1.08 mg TE/g d.m.) due to the dense hydrogel structure effectively enclosing the elderberry extract. Sequential thermal and HHP induction was more effective in developing pea protein–psyllium hydrogels for elderberry extract entrapment.
Intelligent Risk Evaluation for Investment Banking IPO Business Based on Text Analysis
Authors: Zhang Lei , Wang Chao , Liu Xiaoxing
Published: August 2024

By constructing a text quality analysis system and company quality analysis system based on a prospectus, the intelligent analysis method of investment banking IPO business risk is proposed based on the machine learning method and text analysis technology. Taking the Sci-Tech Innovation Board in China as a sample, the empirical analysis results show that the text quality and the company quality disclosed in the prospectus can affect the withdrawal rate of investment banking IPO business. By carrying out a text analysis and machine learning on the text quality and company quality, the risk of investment banking IPO business can be predicted intelligently and effectively. The research results can not only improve the business efficiency of investment banking IPO, and save resource cost, but also improve the standardization and authenticity of investment banking IPO business.
A Green Lantern for the Surgeon: A Review on the Use of Indocyanine Green (ICG) in Minimally Invasive Surgery
Authors: Fransvea Pietro , Miccini Michelangelo , Rondelli Fabio , Brisinda Giuseppe , Costa Alessandro , Garbarino Giovanni Maria , Costa Gianluca
Published: August 2024

Indocyanine green (ICG) fluorescence imaging has revolutionized surgical practice across various medical and surgical specialties. This article reviews the clinical applications of ICG in abdominal, urological, thoracic, and gynecological surgery. ICG fluorescence imaging has been widely adopted in general surgery for various applications, including perfusion assessment, intraoperative visualization of the ureter, and tumor localization. It is particularly valuable in evaluating anastomotic leaks and aiding in precise tumor resection during minimally invasive surgeries. Studies have shown mixed results on its effectiveness in reducing anastomotic leak rates, highlighting the need for further research. In thoracic surgery, ICG facilitates the identification and resection of pulmonary bullae, as well as the precise localization of pulmonary nodules during video-assisted surgery. In urology, ICG aids in localizing renal tumors and guiding selective arterial occlusion during partial nephrectomy. Its role in identifying the lymphatic pathway in prostate cancer and sentinel lymph node biopsy in gynecological cancer is also discussed. Despite its benefits, the use of ICG fluorescence faces challenges such as limited tissue penetration, the potential for false results, a lack of standardized protocols, and high equipment costs. Nonetheless, it remains a powerful tool that could improve surgical outcomes.
A Mild Increase in Serum Creatinine after Surgery Is Associated with Increased Mortality
Authors: Xu Lingyi , Tang Linger , Zheng Xizi , Yang Li
Published: August 2024

Background: Acute kidney injury (AKI), a prevalent postoperative complication, predominantly manifests as stage 1, characterized by a mild elevation in serum creatinine (SCr). There is yet to be a consensus regarding the association between stage 1 AKI and adverse outcomes in surgical patients. Methods: This retrospective study enrolled adult patients who underwent at least one surgery during hospitalization from the MIMIC IV database. AKI was diagnosed when the KDIGO creatinine criteria were satisfied within 7 days after surgery. Stage 1a AKI was defined as an absolute increase in SCr of 26.5 μmol/L, and stage 1b was defined as a 50% relative increase. Stage 1 AKI was also divided into transient and persistent substages based on whether the AKI recovered within 48 h after onset. The association between stage 1 AKI and its substages and in-hospital mortality was evaluated. Results: Among 49,928 patients enrolled, 9755 (19.5%) developed AKI within 7 days after surgery, of which 7659 (78.5%) presented with stage 1 AKI. The median follow-up was 369 (367, 372) days. Stage 1 AKI was significantly associated with in-hospital mortality after adjustment (aHR, 2.73; 95% CI, 2.29, 3.26). Subgroup analyses showed that the risk of stage 1 AKI on in-hospital mortality was attenuated by age ≥ 65 years (p for interaction = 0.017) or a baseline eGFR < 60 mL/min per 1.73 m2 (p for interaction = 0.001). Compared with non-AKI, patients with stage 1b (aHR, 3.06; 95% CI, 2.56, 3.66) and persistent stage 1 (aHR, 2.03; 95% CI, 1.61, 2.57) AKI had an increased risk of in-hospital mortality; however, this risk was not significant in those with stage 1a (aHR, 1.01; 95% CI, 0.68, 1.51) and transient stage 1 (aHR, 1.11; 95% CI, 0.79, 1.57) AKI. Conclusions: Stage 1 AKI exhibits an independent correlation with a heightened mortality risk among surgical patients. Consequently, a tailored adaptation of the KDIGO AKI classification may be necessitated for the surgical population, particularly those presenting with decreased baseline kidney function.
Single Incision Sling Surgery for Female Stress Urinary Incontinence: A Retrospective Cohort Single-Institution Study
Authors: Qatawneh Ayman , Thekrallah Fidaa , Alaqqad Huda M. , AlTayyar Maysa A. , Ahmed Reem F. , Ashour Tala O.
Published: August 2024

Background: Stress urinary incontinence (SUI) affects around 35% of adult women and has a significant impact on quality of life. A single incision sling (SIS), such as Altis®, was introduced to improve original slings and avoid complications. The present study aimed to evaluate the SIS Altis® subjective and objective cure rates of women with SUI, mixed urinary incontinence (MUI), recurrent SUI, and SUI with concomitant prolapse and report its complications from one single medical center. Methodology: A retrospective cohort, unsponsored study was conducted at the Jordan University Hospital. All women patients were treated with the SIS Altis® procedure, and prolapse procedures were also completed as necessary. The chi square analysis for the cure rates was conducted between the subgroups. Results: From June 2016 to June 2019, 111 women patients with a mean age of 48.0 ± 11.3 years underwent a SIS Altis® procedure. The overall outcome resulted in 81% and 85% of patients being subjectively and objectively cured. The subjectively cured MUI patients were significantly fewer than SUI patients (70% versus 86%, p < 0.05), and patients with recurrent SUI had significantly lower rates (56% for subjective and objective cure rates; p < 0.01 and 0.001). Of the 44 patients who underwent SIS Altis® and concomitant vaginal repair surgery, no significant differences in subjective and objective cure rates were observed. Only 2.7% of women had mild pain, 2.7% had vaginal tape erosion, and 9% had to be re-operated on. Conclusions: The Altis® procedure is effective in women who suffer from SUI for a 19-month follow-up period. However, recurrent SUI patients had lower subjective and objective cure rates than primary SUI patients. Further research is needed with a larger sample size in a prospective study design to determine the effectiveness of single SIS in patients with recurrent SUI.
Distal Triceps Tendon Repair in Strength Athletes Leads to Satisfactory Return to Sports: A Retrospective Analysis of 22 Cases
Authors: Gruber Michael Stephan , Bischofreiter Martin , Rittenschober Felix , Schachermayr Michael , Ortmaier Reinhold , Ritsch Mathias
Published: August 2024

Background: Distal triceps brachii tendon rupture (DTTR) is a relatively rare injury that is common in bodybuilding and high-intensity contact sports and can lead to significant functional impairment of the elbow joint. This study was conducted to evaluate clinical outcomes and the rate of return to sports among competitive bodybuilders and high-demand strength athletes after surgical repair of DTTR. Methods: This retrospective case series was performed in an institutional setting in tertiary health care. Return to sports of 22 competing or high-demand strength athletes (meaning three or more exercises per week) were analyzed pre- and postoperatively after surgical repair of DTTR using a hybrid technique of transosseous sutures and anchor fixation. Descriptive statistics were used to analyze demographic variables, and independent and paired t-tests were used to assess clinical outcomes. Results: The follow-up showed that from pre- to postoperatively, there was no deterioration in the number of sports disciplines (2.4 and 2.5 sporting activities per person, respectively; p = 0.540) or in the frequency of weekly training (4.1 and 4.1 times per person, respectively; p = 0.329). The postoperative visual analog scale for pain (from 6.0 to 1.6, p < 0.001), level of fitness (from 5.1 to 2.6, p = 0.002), and ability to train (from 5.2 to 1.3, p < 0.001) improved significantly. The time of return to sports was 1.5–3 months and 4–6 months after the surgery for ten patients each. The overall rate of return to sports was 95%, whereas 86% returned to the preinjury level of sporting activity. Conclusions: Repair of DTTR leads to high rates of return to sports in competitive athletes.
The Experience of a Tertiary Referral Center with Endoscopic Management and Combining Percutaneous Intervention for the Treatment of Walled-Off Necrosis: A Stepwise Approach
Authors: Atay Ali , Yuksel Ilhami
Published: August 2024

Background: This study aimed to assess the effectiveness and safety of endoscopic management in patients with walled-off necrosis and additionally explore the results of a stepwise approach for combining percutaneous intervention in cases where endoscopic management was inadequate. Methods: We included cases of endoscopic management for walled-off necrosis between February 2019 and December 2023. Results: Endoscopic management was performed in 11 patients. The median largest dimension was 150 mm. Multiple cavities were present in four patients. Technical success was 90.9%, while clinical success with only endoscopic management was 36.3%. Clinical success could not be achieved with only endoscopic management in patients with a large diameter (≥125 mm) or multi-lobulated walled-off necrosis. Combining percutaneous intervention resulted in success for all patients. Two patients experienced major complications: one suffered from major bleeding, while the other experienced perforation, necessitating surgical intervention. The patient with perforation died due to multi-organ failure. Conclusions: Endoscopic management is recommended as the primary treatment method for walled-off necrosis due to its less invasive and higher safety profile. In cases involving large or multi-lobulated walled-off necrosis where clinical success cannot be achieved, combining percutaneous intervention is highly successful and safe. Ultimately, this approach can minimize the need for more invasive surgery.
Performance of GFRP-Confined Rubberized Engineered Cementitious Composite Columns
Authors: Nawar Mahmoud T. , Selim Mohamed , Zaghlal Mahmoud , El-Zohairy Ayman , Emara Mohamed
Published: August 2024

In coastal regions, the deterioration of structures and bridges due to environmental conditions and corrosion is a significant concern. To combat these issues, the use of corrosion-resistant materials like fiber-reinforced polymers (FRPs) materials, engineered cementitious composites (ECCs), and rubberized ECCs (RECC) shows promise as normal concrete (NC) alternatives by providing increased ductility and energy absorption properties. The effectiveness of confining concrete columns using GFRP tubes with ECC/RECC was assessed in this research by evaluating their performance through compression and push-out tests. The study explored key parameters such as GFRP tube thickness and the presence of shear connectors along the tube height, as well as examining various types of concrete. Additionally, a comprehensive parametric investigation utilizing finite element analysis (FEA) was conducted to analyze how different factors influence the behavior of confined concrete columns. These factors included the effect of GFRP tube thickness and diameter on the overall behavior of different types of confined concretes. The results demonstrate that GFRP tubes significantly enhance column capacity, while the presence of ECC/RECC exhibits even greater improvements in capacity, stiffness, and toughness compared to NC. This approach shows promise in reinforcing coastal infrastructure and addressing corrosion-related concerns effectively.
Stability Assessment of a Catamaran Using Sea Trials
Authors: Matthews Nigel , Joiner Keith F. , Smith Warren F.
Published: August 2024

Despite the continued rise in popularity of powered catamarans for recreational and commercial applications, there is limited published research on the factors that improve or reduce a powered catamaran’s hydrodynamic stability. There is no definitive research on a catamaran’s hydrodynamic stability during a turn, and current regulations to control the risks are proving ineffective for modern speeds and power. Research on the hydrodynamic stability of catamarans was conducted using a custom-built vessel and its multi-sensor data logger. Test results confirmed serious concerns for safety regulation and acceptance testing of powered catamarans for hydrodynamic stability. The experiments have produced new insights as to why powered catamarans are at risk of capsizing and created a baseline for future testing. The work reported in this article provides an original characterisation of the multi-factor relationships that impact the instability of a powered planing catamaran. The results provide a starting point for the creation of a predictive model and approach to improve catamaran design and safety.
Numerical Study on Hydroelastic Responses of Submersible High-Density Polyethylene Circular Seaweed Platforms Held by Single-Point Mooring System and Buoys
Authors: Nguyen Huu-Phu , Huang Chenxuan , von Herzen Brian , Wang Chien-Ming
Published: August 2024

This paper investigates the hydroelastic behavior of submersible circular seaweed platforms under wave action. The circular platform comprises circular collars constructed from high-density polyethylene (HDPE) pipes and seaweed grow-out lines arranged in the radial direction. The HDPE pipes may be filled with air, seawater, or pressurized seawater. The platform is kept in place by using a single-point mooring system and buoys. The platform may be lowered to over a hundred meters below the water surface to allow the seaweed to be soaked in cold nutrient-rich waters during the night and be raised to the surface for photosynthesis during the day. Also, the platform will be submerged during storms to avoid strong surface waves. The submergence is achieved by using a service vessel and surface buoys that secure the submerged platform with ropes. The hydroelastic analysis of the platform is performed using AquaSim software (v. 2.18), which has been developed specifically for hydroelastic analysis of aquaculture infrastructure. It is found that the hydroelastic response of the seaweed platform can be reduced by filling HDPE pipes with seawater and through the installation of seaweed grow-out lines. It is also found that the compressive stresses in HDPE pipes can be reduced by pressurizing the filled seawater, thereby keeping them below the allowable compressive stresses for severe sea states where pipes with unpressurized seawater show excessive compressive stresses.
Adriana Negreiros and a Feminist Ethics of Testimonial Narrative: Reflections on Life Will Never Be the Same
Authors: Gomes Barbosa Karina
Published: August 2024

I seek to analyze the narrative construction of the reporter’s book A Vida Nunca Mais Será a Mesma (Life Will Never Be the Same Again, 2021), which tells stories of sexual violence against women and also features the first-person account of the author herself, Adriana Negreiros. I try to understand (a) how journalistic fundamentals such as precision and objectivity are articulated/tensioned with lacunar and fragmentary traces of testimony; and (b) how adopting a feminist/gendered perspective on journalistic narrative can bring to light traumatic female experiences that, throughout history, have been placed in the background. To do this, I examine the book and an interview conducted with the author in 2023, concluding that a feminist approach to journalism and testimony can open up affective spaces for women’s stories to be told.
The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review
Authors: Bose Debalina , Famurewa Ademola C. , Akash Aman , Othman Eman M.
Published: August 2024

Within the domain of conventional oncochemotherapeutics, anticancer chemotherapy (AC) has emerged as a potent strategy for the treatment of cancers. AC is the mainstay strategy for solid and non-solid cancer treatment. Its mechanistic action targets the blockage of DNA transcription and the dysregulation of cell cycle machinery in cancer cells, leading to the activation of death pathways. However, the attendant side effect of toxicity inflicted by AC on healthy tissues presents a formidable challenge. The crucial culprit in the AC side effect of toxicity is unknown, although oxidative stress, mitochondrial impairment, inflammatory cascades, autophagy dysregulation, apoptosis, and certain aberrant signaling have been implicated. Honey is a natural bee product with significant health benefits and pharmacological properties. Interestingly, the literature reports that honey may proffer a protection mechanism for delicate tissue/organs against the side effect of toxicity from AC. Thus, this review delves into the prospective role of honey as an alleviator of the AC side effect of toxicity; it provides an elucidation of the mechanisms of AC toxicity and honey’s molecular mechanisms of mitigation. The review endeavors to unravel the specific molecular cascades by which honey orchestrates its mitigating effects, with the overarching objective of refining its application as an adjuvant natural product. Honey supplementation prevents AC toxicity via the inhibition of oxidative stress, NF-κB-mediated inflammation, and caspase-dependent apoptosis cascades. Although there is a need for increased mechanistic studies, honey is a natural product that could mitigate the various toxicities induced by AC.