bluuebunny/crossref_metadata_2025 huggingface dataset:
Essential oils of plants and their combinations as an alternative adulticides against Anopheles gambiae (Diptera: Culicidae) populations
Authors: Balboné Mahamoudou , Sawadogo Ignace , Soma Dieudonné Diloma , Drabo Samuel Fogné , Namountougou Moussa , Bayili Koama , Romba Rahim , Meda Georges Benson , Nebié Honorat Charles Roger , Dabire Roch K. , Bassolé Imaël H. N. , Gnankine Olivier
Published: November 2022

The persistence of malaria and the increasing of resistance of Anopheles gambiae species to chemicals remain major public health concerns in sub-Saharan Africa. Faced to these concerns, the search for alternative vector control strategies as use of essential oils (EOs) need to be implemented. Here, the five EOs from Cymbopogon citratus, Cymbopogon nardus, Eucalyptus camaldulensis, Lippia multiflora, Ocimum americanum obtained by hydro distillation were tested according to World Health Organization procedures on An. gambiae “Kisumu” and field strains collected in “Vallée du Kou”. Also, the binary combinations of C. nardus (Cn) and O. americanum (Oa) were examined. As results, among the EOs tested, L. multiflora was the most efficient on both An. gambiae strains regarding KDT50 (50% of mosquitoes knock down time) and KDT95 and rate of morality values. Our current study showed that C8 (Cn 80%: Oa 20%) and C9 (Cn 90%: Oa 10%), were the most toxic to An. gambiae strain “Vallée de Kou” (VK) with the mortality rates reaching 80.7 and 100% at 1% concentration, respectively. These two binary combinations shown a synergistic effect on the susceptible population. However, only C9 gave a synergistic effect on VK population. The bioactivity of the two EOs, C. nardus and O. americanum, was improved by the combinations at certain proportions. The resistance ratios of all EOs and of the combinations were low (< 5). The combinations of C. nardus and O. americanum EOs at 90: 10 ratio and to a lesser extent L. multiflora EO, could be used as alternative bio-insecticides against malaria vectors resistant to pyrethroids in vector control programmes.
An isolated population reveals greater genetic structuring of the Australian dingo
Authors: Stephens Danielle , Fleming Peter J. S. , Sawyers Emma , Mayr Tim P.
Published: November 2022

The Australian dingo is a recent anthropogenic addition to the Australian fauna, which spread rapidly across the continent and has since widely interbred with modern dogs. Genetic studies of dingoes have given rise to speculation about their entry to the continent and subsequent biogeographic effects, but few studies of their contemporary population structure have been conducted. Here we investigated the dingo ancestry and population structure of free-living dogs in western Victoria and contrasted it with a wider southern Australian sample. We wished to determine whether their geographic isolation was mirrored in genetic isolation. To address this question, we analysed 34 microsatellite markers using Bayesian clustering and discriminant analysis of principal components, and summarised genetic diversity at the population and individual level. The broader southern Australia sample (n = 1138) comprised mostly hybrid animals, with 30% considered pure dingoes. All western Victorian individuals (n = 59) appeared to be hybrids with high dingo ancestry. The population showed no evidence of admixture with other populations and low genetic diversity on all measures tested. Based upon our characterisation of this unusual mainland population, we advise against assuming homogeneity of dingoes across the continent.
Analysis of amplification and association polymorphisms in the bovine beta-defensin 129 (BBD129) gene revealed its function in bull fertility
Authors: Solanki Subhash , Kashyap Poonam , Ali Syed Azmal , Kumar Vijay , Vats Ashutosh , Pukhrambam Martina , Kumar Rakesh , De Sachinandan , Datta Tirtha Kumar
Published: November 2022

β-defensins are adsorbable on the sperm surface in the male reproductive tract (MRT) and enhance sperm functional characteristics. The beta-defensin 129 (DEFB129) antimicrobial peptide is involved in sperm maturation, motility, and fertilization. However, its role in bovine fertility has not been well investigated. This study examines the relationship between the bovine BBD129 gene and Bos indicus x Bos taurus bull fertility. The complete coding sequence of BBD129 mRNA was identified by RNA Ligase Mediated-Rapid Amplification of cDNA End (RLM-RACE) and Sanger sequencing methodologies. It consisted of 582 nucleotides (nts) including 5' untranslated region (UTR) (46nts) and 3'UTR (23nts). It conserves all beta-defensin-like features. The expression level of BBD129 was checked by RT-qPCR and maximal expression was detected in the corpus—epididymis region compared to other parts of MRT. Polymorphism in BBD129 was also confirmed by Sanger sequencing of 254 clones from 5 high fertile (HF) and 6 low fertile (LF) bulls at two positions, 169 T > G and 329A > G, which change the S57A and N110S in the protein sequence respectively. These two mutations give rise to four types of BBD129 haplotypes. The non-mutated TA-BBD129 (169 T/329A) haplotype was substantially more prevalent among high-fertile bulls (P < 0.005), while the double-site mutated GG-BBD129 (169 T > G/329A > G) haplotype was significantly more prevalent among low-fertile bulls (P < 0.005). The in silico analysis confirmed that the polymorphism in BBD129 results in changes in mRNA secondary structure, protein conformations, protein stability, extracellular-surface availability, post-translational modifications (O-glycosylation and phosphorylation), and affects antibacterial and immunomodulatory capabilities. In conclusion, the mRNA expression of BBD129 in the MRT indicates its region-specific dynamics in sperm maturation. BBD129 polymorphisms were identified as the deciding elements accountable for the changed proteins with impaired functionality, contributing to cross-bred bulls' poor fertility.
Influence of the filler distribution on PDMS-graphene based nanocomposites selected properties
Authors: Łapińska Anna , Grochowska Natalia , Antonowicz Jerzy , Michalski Przemysław , Dydek Kamil , Dużyńska Anna , Daniszewska Agata , Ojrzyńska Milena , Zeranska Klaudia , Zdrojek Mariusz
Published: November 2022

Insufficient homogeneity is one of the pressing problems in nanocomposites’ production as it largely impairs the properties of materials with relatively high filler concentration. Within this work, it is demonstrated how selected mixing techniques (magnetic mixer stirring, calendaring and microfluidization) affect filler distribution in poly(dimethylsiloxane)-graphene based nanocomposites and, consequently, their properties. The differences were assessed via imaging and thermal techniques, i.a. Raman spectroscopy, differential scanning calorimetry and thermogravimetry. As microfluidization proved to provide the best homogenization, it was used to prepare nanocomposites of different filler concentration, whose structural and thermal properties were investigated. The results show that the concentration of graphene significantly affects polymer chain mobility, grain sizes, defect density and cross-linking level. Both factors considered in this work considerably influence thermal stability and other features which are crucial for application in electronics, EMI shielding, thermal interface materials etc.
Influence of the coiling porosity on the risk reduction of the cerebral aneurysm rupture: computational study
Authors: Sheidani Armin , Barzegar Gerdroodbary M. , Poozesh Amin , Sabernaeemi Amir , Salavatidezfouli Sajad , Hajisharifi Arash
Published: November 2022

The formation and progress of cerebral aneurysm is highly associated with hemodynamic factors and blood flow feature. In this study, comprehensive efforts are done to investigate the blood hemodynamic effects on the creation and growth of the Internal Carotid Artery. The computational fluid dynamic method is used for the visualization of the bloodstream inside the aneurysm. Transitional, non-Newtonian and incompressible conditions are considered for solving the Navier–Stokes equation to achieve the high-risk region on the aneurysm wall. OSI and WSS of the aneurysm wall are compared within different blood flow stages. The effects of blood viscosity and coiling treatment on these factors are presented in this work. Our study shows that in male patients (HCT = 0.45), changing the porosity of coiling from 0.89 with 0.79 would decreases maximum OSI up to 75% (in maximum acceleration). However, this effect is limited to about 45% for female patients (HCT = 0.35).
Data fusion of electronic noses and electronic tongues aids in botanical origin identification on imbalanced Codonopsis Radix samples
Authors: Wang Shuying , Lin Zhaozhou , Zhang Bei , Du Jing , Li Wen , Wang Zhibin
Published: November 2022

Codonopsis Radix (CR) is an edible food and traditional Chinese herb medicine in China. Various varieties of Codonopsis Radix have different tastes. To make the flavor of processed food stable, two kinds of electronic sensory devices, electronic nose and electronic tongue, were used to establish a discrimination model to identify the botanical origin of each sample. The optimal model built on the 88 batches of samples was selected from the models trained with all combination of two pretreatment methods and three classification methods. A comparison were performed on the models trained on the data collected by electronic nose and electronic tongue. The results showed that the model trained on the fused dataset outperformed the models trained separately on the electronic nose data and electronic tongue data. The two preprocessing approaches could improve the prediction performance of all classification methods. Classification and Regression Tree approach performed better than Partial Least Square Discriminant Analysis and Linear Discriminant Analysis in terms of accuracy. But Classification and Regression Tree tends to assign the samples of minority class to the majority class. Meanwhile, Partial Least Square Discriminant Analysis keeps a good balance between the identification requirements of all the two groups of samples. Taking all the results above, the model built using the Partial Least Square Discriminant Analysis method on the fused data after z-score was used to identify the botanical origin of Codonopsis Radix.
Machine learning for morbid glomerular hypertrophy
Authors: Ushio Yusuke , Kataoka Hiroshi , Iwadoh Kazuhiro , Ohara Mamiko , Suzuki Tomo , Hirata Maiko , Manabe Shun , Kawachi Keiko , Akihisa Taro , Makabe Shiho , Sato Masayo , Iwasa Naomi , Yoshida Rie , Hoshino Junichi , Mochizuki Toshio , Tsuchiya Ken , Nitta Kosaku
Published: November 2022

A practical research method integrating data-driven machine learning with conventional model-driven statistics is sought after in medicine. Although glomerular hypertrophy (or a large renal corpuscle) on renal biopsy has pathophysiological implications, it is often misdiagnosed as adaptive/compensatory hypertrophy. Using a generative machine learning method, we aimed to explore the factors associated with a maximal glomerular diameter of ≥ 242.3 μm. Using the frequency-of-usage variable ranking in generative models, we defined the machine learning scores with symbolic regression via genetic programming (SR via GP). We compared important variables selected by SR with those selected by a point-biserial correlation coefficient using multivariable logistic and linear regressions to validate discriminatory ability, goodness-of-fit, and collinearity. Body mass index, complement component C3, serum total protein, arteriolosclerosis, C-reactive protein, and the Oxford E1 score were ranked among the top 10 variables with high machine learning scores using SR via GP, while the estimated glomerular filtration rate was ranked 46 among the 60 variables. In multivariable analyses, the R2 value was higher (0.61 vs. 0.45), and the corrected Akaike Information Criterion value was lower (402.7 vs. 417.2) with variables selected with SR than those selected with point-biserial r. There were two variables with variance inflation factors higher than 5 in those using point-biserial r and none in SR. Data-driven machine learning models may be useful in identifying significant and insignificant correlated factors. Our method may be generalized to other medical research due to the procedural simplicity of using top-ranked variables selected by machine learning.
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening
Authors: Kaufmann Johanna , Blum Nina Kathleen , Nagel Falko , Schuler Anna , Drube Julia , Degenhart Carsten , Engel Julian , Eickhoff Jan Eicke , Dasgupta Pooja , Fritzwanker Sebastian , Guastadisegni Maria , Schulte Clemens , Miess-Tanneberg Elke , Maric Hans Michael , Spetea Mariana , Kliewer Andrea , Baumann Matthias , Klebl Bert , Reinscheid Rainer K. , Hoffmann Carsten , Schulz Stefan
Published: November 2022

Analysis of agonist-driven phosphorylation of G protein-coupled receptors (GPCRs) can provide valuable insights into the receptor activation state and ligand pharmacology. However, to date, assessment of GPCR phosphorylation using high-throughput applications has been challenging. We have developed and validated a bead-based immunoassay for the quantitative assessment of agonist-induced GPCR phosphorylation that can be performed entirely in multiwell cell culture plates. The assay involves immunoprecipitation of affinity-tagged receptors using magnetic beads followed by protein detection using phosphorylation state-specific and phosphorylation state-independent anti-GPCR antibodies. As proof of concept, five prototypical GPCRs (MOP, C5a1, D1, SST2, CB2) were treated with different agonizts and antagonists, and concentration-response curves were generated. We then extended our approach to establish selective cellular GPCR kinase (GRK) inhibitor assays, which led to the rapid identification of a selective GRK5/6 inhibitor (LDC8988) and a highly potent pan-GRK inhibitor (LDC9728). In conclusion, this versatile GPCR phosphorylation assay can be used extensively for ligand profiling and inhibitor screening.
Synthesis and characterization of a biocompatible 13C1 isotopologue of trityl radical OX071 for in vivo EPR viscometry
Authors: Poncelet Martin , Ngendahimana Thacien , Gluth Teresa D. , Hoblitzell Emily H. , Eubank Timothy D. , Eaton Gareth R. , Eaton Sandra S. , Driesschaert Benoit
Published: November 2022

We report an isotopologue of the trityl radical OX071, labeled with 13C at the central carbon highly sensitive to molecular tumbling.
Ultra-small NIR J-aggregates of BODIPY for potent phototheranostics
Authors: Liu Kunmei , Liu Hongxin , Li Chaonan , Xie Zhigang , Zheng Min
Published: November 2022

BNPs have ultra-small size, high photothermal efficiency, enhanced cellular uptake and preferable tumor accumulation. In vitro and in vivo experiments proved BNPs could be effectively internalized and achieve NIR-imaging guided phototherapy.
Ultrafine CoFe2O4quantum dots as an oxygen electrocatalyst for rechargeable zinc air batteries
Authors: Luo Fang , Li Min , Yang Zehui
Published: November 2022

CoFe2O4quantum dots (QDs) showed a battery performance 1.79 times higher than that displayed by the benchmark Pt/C–IrO2.
Supercapacitive study for electrode materials around the framework-collapse point of a Ni-based coordination polymer
Authors: Hong Ye , Chen Tianqi , Wang Kuaibing , Chen Changyun , Zhang Cheng , Wu Hua
Published: November 2022

Four derivative electrode materials have been obtained by selecting the calcination temperature based on the collapse point of a Ni-based coordination polymer precursor. Besides, their electrochemical performances are investigated.
Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers
Authors: Longatte Guillaume , Lisi Fabio , Chen Xueqian , Walsh James , Wang Wenqian , Ariotti Nicholas , Boecking Till , Gaus Katharina , Gooding J. Justin
Published: November 2022

This article focuses on identifying the best experimental conditions to encapsulate single molecules (or single binding pairs) into size-dispersed liposomes.
Ion formation mechanism of cortisone molecules and clusters in charged nanodroplets
Authors: Jiang Shuai , Apsokardu Michael J. , Liu Yi-Rong , Wang Chun-Yu , Huang Teng , Johnston Murray V.
Published: November 2022

Mass spectrometry measurements coupled with molecular dynamics show that the droplet-assisted ionization (DAI) source produces ions from charged droplets with the characteristics of both the ion evaporation and charge residue models.
Techno-economic and greenhouse gas emission assessment of carbon negative pyrolysis technology
Authors: Ganguly Arna , Brown Robert C. , Wright Mark Mba
Published: November 2022

Carbon-negative energy removes carbon dioxide from the atmosphere while providing energy to society.
A microfluidic impedance platform for real-time, in vitro characterization of endothelial cells undergoing fluid shear stress
Authors: Velasco Vanessa , Soucy Patricia , Keynton Robert , Williams Stuart J.
Published: November 2022

Monitoring different adherent cell subpopulations sizes and their environment under fluid shear stress conditions with a microfluidic impedance platform.
A nanofiber hydrogel derived entirely from ocean biomass for wound healing
Authors: Sun Tian-Cai , Yan Bing-Yu , Ning Xu-Chao , Tang Zhi-Yue , Hui Chao , Hu Mao-zhi , Ramakrishna Seeram , Long Yun-Ze , Zhang Jun
Published: November 2022

Fish scale/sodium alginate/chitosan nanofiber hydrogels for wound healing.
Catalytic application of a novel melamine–naphthalene-1,3-disulfonic acid metal–organic framework in the synthesis of β-acetamido ketones
Authors: Babamoradi Jamshid , Alavinia Sedigheh , Ghorbani-Vaghei Ramin , Azadbakht Reza
Published: November 2022

We synthesized a porous multifunctional metal–organic-framework (MOF) [UiO-66-Mel-NHC10H5(SO3H)2] based on zirconium by post-synthetic modification of UiO-66-NH2.
Synthesis and antiproliferative activity of 1H-1,2,3-triazole-4H-chromene-d-glucose hybrid compounds with dual inhibitory activity against EGFR/VEGFR-2 and molecular docking studies
Authors: Nguyen Dinh Thanh , Do Son Hai , Le Thi Huyen , Nguyen Thi Hanh , Nguyen Minh Huyen , Vu Thi Ngoc Bich , Pham Thi Thu Hien , Vu Ngoc Toan , Hoàng Thi Kim Van , Nguyen Thi Kim Giang
Published: November 2022

1H-1,2,3-Triazole-4H-chromene-d-glucose hybrids were synthesized and screened for their anticancer activity in vitro against MCF-7, HepG2, HeLa and WI-38 cells, and several had dual inhibitions against EGFR/VEGFR-2. IFD, MM-GBSA and MD simulations were also carried out.
Visible light-triggered synthesis of oxime ethers using tetrabromomethane as a mediator
Authors: Tu Meng , Chen Bo-Jiang , Rukhsana  , Cui Wenying , Fu Wentao , Shen Chengshuo , Shen Yong-Miao
Published: November 2022

A straightforward synthetic method of oxime ethers starting from tetrahydrofuran or cyclic ethers and various oxime derivatives with CBr4as a mediator.
Zeolite imidazolate framework/g-C3N4 derived Co nanoparticles embedded in nitrogen doped carbon for efficient hydrogenation of phenol
Authors: Qiu Zegang , Li Zongxuan , Ma Shaobo , Li Zhiqin , Cao Yueling , Li Guangyu
Published: November 2022

Co/NPCN fabricated by pyrolysis of ZIF-67/g-C3N4 presents high efficiency in the hydrogenation of phenol to cyclohexanol under mild conditions.
Multicolor emission of nonaromatic linear polysiloxanes based on local conjugation chains
Authors: He Yanyun , Ding Fan , Zhao Yan , Tian Wei , Feng Weixu , Yan Hongxia
Published: November 2022

The longer the local conjugation in the main chain (–CC–Si–O–CO) is, the more conducive to its multicolor fluorescence.
Interface architecture of low-cost and stable three-dimensional composite counter electrodes for QDSCs
Authors: Zhang Jingyu , Chen Xiufen , Dong Limin , Zheng Wei
Published: November 2022

CuS or nanographite as active sites were loaded into acidized MWCNT to build 3D CEs used in QDSCs. The interface and microstructure were modified for faster electron transfer on electrolyte/CE interface by modifying the preparation routes.
Metal–oxide heterointerface synergistic effects of copper–zinc systems for highly selective CO2-to-CH4 electrochemical conversion
Authors: Ma Xingcheng , Jiao Dongxu , Fan Jinchang , Dong Yilong , Cui Xiaoqiang
Published: November 2022

Highly efficient CO2 electroreduction to methane (CH4) is achieved over a precisely controlled Cu–ZnO heterointerface system, delivering a superior activity with a faradaic efficiency of up to 72.4% at −0.7 V vs. RHE.
Interlayer engineering of a V2O5 anode toward high-rate and durable dual-ion batteries
Authors: Qiu Wenda , Tian Yunlei , Lin Shuting , Lei Aihua , Geng Zhangqi , Huang Kaitao , Chen Jiancong , Huang Fuchun , Feng Huajie , Lu Xihong
Published: November 2022

Dual-ion batteries (DIBs) have gained widespread attention thanks to their high operating voltage, low cost, and environmental friendliness.
Ascorbic acid enhanced ferrous/persulfate system for degradation of tetracycline contaminated groundwater
Authors: Wang Hengyi , Zhao Liyang , Li Qian , Liu Xixiang , Liang Liying , Cen Jianmei , Liu Yan , Pan Honghui
Published: November 2022

Persulfate (PS) activated by Fe(ii) has been widely investigated for degradation of contaminants.
Lewis acid-catalyzed [4 + 2] cycloaddition of donor–acceptor cyclobutanes with iminooxindoles: access to spiro[piperidine-3,2′-oxindoles]
Authors: Chen Zuliang , Yan Keyi , Luo Hui , Yan Jun , Zeng Yang
Published: November 2022

A Lewis acid-catalyzed [4 + 2] cycloaddition reaction from D–A cyclobutanes and iminooxindoles, providing the corresponding spiro[piperidine-3,2′-oxindoles] under mild conditions.
Characterization and antibacterial behavior of an edible konjac glucomannan/soluble black tea powder hybrid film with ultraviolet absorption
Authors: Xu Wei , Jia Yin , Wei Jingjing , Ning Yuli , Sun Haomin , Jiang Lanxi , Chai Liwen , Luo Denglin , Cao Shiwan , Shah Bakht Ramin
Published: November 2022

KGM/SBTP film was prepared using KGM and a soluble black tea film (SBTP) as substrates, and its hygroscopicity, thermal properties, light barrier properties, microstructure, and bacteriostatic properties were evaluated.
Synthesis, characterization and anticancer activities of Zn2+, Cu2+, Co2+ and Ni2+ complexes involving chiral amino alcohols
Authors: Umar Q. , Huang Y. H. , Nazeer A. , Yin H. , Zhang J. C. , Luo M. , Meng X. G.
Published: November 2022

A new type of coordination complexes related with the first transition metal and chiral amino alcohols can effectively fight against the human tumour cell line A549 with an IC50 value of 17.71 μM.
Effects of fluorine bonding and nonbonding interactions on 19F chemical shifts
Authors: Lu Yang , Sun Mingming , Xi Ning
Published: November 2022

19F-NMR signals are sensitive to local electrostatic fields and are useful in probing protein structures and dynamics.
Mixed-metal Zr/Ti MIL-173 porphyrinic metal–organic frameworks as efficient photocatalysts towards solar-driven overall water splitting
Authors: Gikonyo Ben , Montero-Lanzuela Eva , Baldovi Herme G. , De Siddhartha , Journet Catherine , Devic Thomas , Guillou Nathalie , Tiana Davide , Navalon Sergio , Fateeva Alexandra
Published: November 2022

A hydrolytically stable metal–organic framework containing Ti(iv) and porphyrinic linkers allows a photoinduced charge separation process for the photocatalytic overall water splitting reaction.
Well-defined electrochemical switching of amphiphilic glycolated poly(3,4-ethylenedioxythiophene)
Authors: Rybakiewicz-Sekita Renata , Gryszel Maciej , Pathak Gaurav , Gańczarczyk Roman , Donahue Mary Jocelyn , Głowacki Eric Daniel
Published: November 2022

The archetypical conducting polymer poly(3,4-ethylenedioxythiophene) can be equipped with a glycol side-chain, which favorably tunes its electrochemical properties and opens new processability options.
High specific capacity and mechanism of a metal–organic framework based cathode for aqueous zinc-ion batteries
Authors: Gou Wenshan , Chen Hao , Xu Zhao , Sun Yifei , Han Xuguang , Liu Mengmeng , Zhang Yan
Published: November 2022

MOF-73 is explored as a novel cathode for aqueous zinc-ion batteries, and a co-contribution zinc ion storage mechanism is illustrated.
Self‐inferring incomplete multi‐view clustering
Authors: Fan Junjun , Ma ZeQi , Wen Jiajun , Lai Zhihui , Xie Weicheng , Wong Wai Keung
Published: November 2022

With the advantage of exploiting complementary and consensus information across multiple views, techniques for Multi‐view Clustering have attracted increasing attention in recent years. However, it is common that data on some views is not completed in real‐world applications, which brings the challenge of partial mapping between the views. To explore the information hidden in the local geometric structure and recover missing instances through mining the information hidden in existing instances, a self‐inferring incomplete multi‐view clustering algorithm is proposed. Firstly, the incomplete multi‐view data is replenished directly and exploited as variables for inferring the missing instances. And then, a feature graph constraint is united in consensus learning. Besides, a similarity graph learning method is imposed to preserve the local manifold structure. At last, the inferred instances are filled in the missing instances for learning better consensus representation in the iterative process. Extensive experiment results show that this method can improve the clustering performance compared with the state‐of‐the‐art methods.
Disentangling the protoplanetary disk gas mass and carbon depletion through combined atomic and molecular tracers
Authors: Sturm J. A. , Booth A. S. , McClure M. K. , Leemker M. , van Dishoeck E. F.
Published: November 2022

Context. The total disk gas mass and elemental C, N, and O composition of protoplanetary disks are crucial ingredients for improving our understanding of planetary formation. Measuring the gas mass is complicated, since H2 cannot be detected in the cold bulk of the disk and the elemental abundances with respect to hydrogen are degenerate with gas mass in all disk models.

Aims. We aim to determine the gas mass and elemental abundances ratios C/H and O/H in the transition disk around LkCa 15, one of the few disks for which HD data are available, in combination with as many chemical tracers as possible.

Methods. We present new NOrthern Extended Millimeter Array observations of CO, 13CO, C18O, and optically thin C17O J = 2−1 lines, along with high angular-resolution Atacama Large Millimeter Array millimeter continuum and CO data to construct a representative model of LkCa 15. Using a grid of 60 azimuthally symmetric thermo-chemical DALI disk models, we translated the observed fluxes to elemental abundances and constrained the best-fitting parameter space of the disk gas mass.

Results. The transitions that constrain the gas mass and carbon abundance the most are C17O J = 2−1, N2H+ J = 3−2 and HD J = 1−0. Using these three molecules, we find that the gas mass in the LkCa 15 disk is Mg = 0.01−0.004+0.01 M⊙, which is a factor of 6 lower than previous estimations. This value is consistent with cosmic ray ionization rates between 10−16−10−18 s−1, where 10−18 s−1 is a lower limit based on the HD upper limit. The carbon abundance is C/H = (3 ± 1.5) × 10−5, implying a moderate depletion of elemental carbon by a factor of 3–9. All other analyzed transitions also agree with these numbers, within a modeling uncertainty of a factor of 2. Using the resolved C2H image we find a C/O ratio of ~1, which is consistent with literature values of H2O depletion in this disk. The absence of severe carbon depletion in the LkCa 15 disk is consistent with the young age of the disk, but stands in contrast to the higher levels of depletion seen in older cold transition disks.

Conclusions. Combining optically thin CO isotopologue lines with N2H+ is promising with regard to breaking the degeneracy between gas mass and CO abundance. The moderate level of depletion for this source with a cold, but young disk, suggests that long carbon transformation timescales contribute to the evolutionary trend seen in the level of carbon depletion among disk populations, rather than evolving temperature effects and presence of dust traps alone. HD observations remain important for determining the disk’s gas mass.
New strong lensing modelling of SDSS J2222+2745 enhanced with VLT/MUSE spectroscopy
Authors: Acebron A. , Grillo C. , Bergamini P. , Caminha G. B. , Tozzi P. , Mercurio A. , Rosati P. , Brammer G. , Meneghetti M. , Nonino M. , Vanzella E.
Published: November 2022

Context.SDSS J2222+2745, atz = 0.489, is one of the few currently known lens clusters with multiple images (six) of a background (z = 2.801) quasar with measured time delays between two image pairs (with a sub-percent relative error for the longer time delay). Systems of this kind can be exploited as alternative cosmological probes through high-precision and accurate strong lensing models.

Aims.We present recent observations from the Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT) and new total mass models of the core of the galaxy cluster SDSS J2222+2745.

Methods.We combine archival multi-band, high-resolution imaging from theHubbleSpace Telescope (HST) with our VLT/MUSE spectroscopic data to securely identify 34 cluster members and 12 multiple images from 3 background sources. We also measure the stellar velocity dispersions of 13 cluster galaxies, down to HSTF160W= 21 mag, enabling an independent estimate of the contribution of the sub-halo mass component to the lens total mass. By leveraging the new spectroscopic dataset, we build improved strong lensing models.

Results.The projected total mass distribution of the lens cluster is best modelled with a single large-scale mass component, a galaxy-scale component, anchored by the VLT/MUSE kinematic information, and an external shear component. The best-fit strong lensing model yields a root mean square separation between the model-predicted and observed positions of the multiple images of 0″​​.29. When analysing the impact of systematic uncertainties, stemming from modelling assumptions and used observables, we find that the resulting projected total mass profile, the relative weight of the sub-halo mass component, and the critical lines are consistent, within the statistical uncertainties. The predicted magnification and time-delay values are, instead, more sensitive to the local details of the lens total mass distribution, and vary significantly among lens models that are similarly good at reproducing the observed multiple image positions. In particular, the model-predicted time delays can differ by a factor of up to ∼1.5.

Conclusions.SDSS J2222+2745 is a promising lens cluster for cosmological applications. However, due to its complex morphology, the relatively low number of secure ‘point-like’ multiple images, and current model degeneracies, it becomes clear that additional information (from the observed surface brightness distribution of lensed sources and the measured time delays) needs to be included in the modelling for accurate and precise cosmological measurements. The full VLT/MUSE secure spectroscopic catalogue presented in this work is made publicly available.
Lifetime of the hypertriton
Authors: Gazda Daniel , Pérez-Obiol Axel , Gal Avraham , Friedman Eliahu
Published: November 2022

Conflicting values of the hypertriton lifetime τ(3ΛH) were derived in relativistic heavy ion (RHI) collision experiments over the last decade. A very recent ALICE Collaboration measurement is the only experiment where the reported τ(3ΛH) comes sufficiently close to the free-Λ lifetime τΛ, as expected naively for a very weakly bound Λ in 3ΛH. We revisited theoretically this 3ΛH lifetime puzzle [1], using 3ΛH and 3He wave functions computed within the ab initio no-core shell model employing interactions derived from chiral effective field theory to calculate the two-body decay rate Γ(3ΛH → 3He + π−). We found significant but opposing contributions arising from ΣNN admixtures in 3ΛH and from π− − 3He final-state interaction. To derive τ(3ΛH), we evaluated the inclusive π− decay rate Γπ− (3ΛH) by using the measured branching ratio Γ(3ΛH → 3He + π−)/Γπ− (3ΛH) and added the π0 contributions through the ΔI = 1/2rule. The resulting τ(3ΛH) varies strongly with the rather poorly known Λ separation energy Esep(3ΛH) and it is thus possible to associate each one of the distinct RHI τ(3ΛH) measurements with its own underlying value of Esep(3ΛH).
Comparison of 3ΛH/4ΛH production cross-section via (K−, π0) reaction at J-PARC
Authors: Akaishi Takaya , Asano Hidemitsu , Chen Xurong , Clozza Alberto , Curceanu Catalina , Del Grande Raffaele , Guaraldo Carlo , Han Chengdong , Hashimoto Tadashi , Iliescu Mihai , Inoue Kentaro , Ishimoto Shigeru , Itahashi Kenta , Iwasaki Masahiko , Ma Yue , Murayama Rie , Miliucci Marco , Noumi Hiroyuki , Ohnishi Hiroyuki , Okada Shinji , Outa Haruhiko , Piscicchia Kristian , Sada Yuta , Sakaguchi Atsushi , Sakuma Fuminori , Sato Masaharu , Scordo Alessandro , Sirghi Diana , Sirghi Florin , Shirotori Kotaro , Suzuki Shoji , Tanida Kiyoshi , Toda Taiga , Tokuda Megumu , Tsuruta Masato , Yamaga Takumi , Yuan Xiaohua , Zhang Hongqiang , Zhang Pengming , Zhang Yapeng
Published: November 2022

Recent heavy-ion collision experiments reported a surprisingly short lifetime for the hypertriton, which has been recognized as the hypertriton lifetime puzzle. Our J-PARC E73 experiment contributes to solve this puzzle with an independent experimental method by employing 3He(K−, π0) 3ΛH reaction. In this contribution, we will demonstrate our capability to provide 3ΛH binding energy information by deriving the production cross section ratio, σ3ΛH/σ4ΛH. The production cross section data for 3ΛH and 4ΛH are already available as the pilot run of E73 experiment and data analysis is in progress.
Possible ΣNN resonances in the 3H(e,e′K+) reaction
Authors: Gibson Benjamin F. , Afnan Iraj R.
Published: November 2022

In a recent JLab 3H(e,e′K+) experiment a structure near the ΣNN threshold was observed, which was interpreted to be a T = 1 resonance. Using separable NN and ΛN−ΣN potentials in the Faddeev equations, we demonstrate that it is possible that both T = 0 and T = 1 resonances may have been excited. Moreover, their pole positions, in our model calculation, are sufficiently close to one another that it is unlikely that these resonances in the ΣNN spectrum can be resolved.
Study of Λn FSI with Λ quasi-free productions on the 3H(e, e′K+)X reaction at JLab
Authors: Itabashi K. , Suzuki K.N. , Pandey B. , Okuyama K. , Gogami T. , Nagao S. , Nakamura S.N. , Tang L. , Abrams D. , Akiyama T. , Androic D. , Aniol K. , Ayerbe Gayoso C. , Bane J. , Barcus S. , Barrow J. , Bellini V. , Bhatt H. , Bhetuwal D. , Biswas D. , Camsonne A. , Castellanos J. , Chen J-P. , Chen J. , Covrig S. , Chrisman D. , Cruz-Torres R. , Das R. , Fuchey E. , Gnanvo K. , Garibaldi F. , Gautam T. , Gomez J. , Gueye P. , Hague T.J. , Hansen O. , Henry W. , Hauenstein F. , Higinbotham D.W. , Hyde C.E. , Kaneta M. , Keppel C. , Kutz T. , Lashley-Colthirst N. , Li S. , Liu H. , Mammei J. , Markowitz P. , McClellan R. E. , Meddi F. , Meekins D. , Michaels R. , Mihovilovic M. , Moyer A. , Nguyen D. , Nycz M. , Owen V. , Palatchi C. , Park S. , Petkovic T. , Premathilake S. , Reimer P.E. , Reinhold J. , Riordan S. , Rodriguez V. , Samanta C. , Santiesteban S.N. , Sawatzky B. , Širca S. , Slifer K. , Su T. , Tian Y. , Toyama Y. , Uehara K. , Urciuoli G.M. , Votaw D. , Williamson J. , Wojtsekhowski B. , Wood S.A. , Yale B. , Ye Z. , Zhang J. , Zheng X.
Published: November 2022

Abstract. An nnΛ is a neutral baryon system with no charge. The study of the pure Λ-neutron system such as nnΛ gives us information on the Λn interaction. The nnΛ search experiment (E12-17-003) was performed at JLab Hall A in 2018. In this article, the Λn FSI was investigated by a shape analysis of the 3H(e, e′K+)X missing mass spectrum, and a preliminary result for the Λn FSI study is given.
X ray spectroscopy on 𝚵− atoms (J-PARC E03, E07 and future)
Authors: Yamamoto Takeshi. O. , Fujita M. , Gogami T. , Harada T. K. , Hayakawa S. H. , Hosomi K. , Ichikawa Y. , Ishikawa Y. , Kamada K. , Kanauchi H. , Koike T. , Miwa K. , Nagae T. , Oura F. , Takahashi T. , Tamura H. , Tanida K. , Ukai M.
Published: November 2022

X-ray spectroscopy of hadronic atoms is a powerful method to study strong interaction between hadrons and nuclei. At J-PARC, we have conducted two experiments, J-PARC E07 and E03, for hadronic atoms with a doubly strange hyperon, Ξ−, aiming at the world-first detection of their X-rays. The first measurement is performed as a byproduct of J-PARC E07 experiment with the hybrid emulsion technique. The second one, J-PARC E03, is a dedicated experiment for detection of Ξ− Fe atom X rays. The preliminary results and the present status of E07 and E03 are shown in this article. Future prospects of Ξ−-atomic X-ray spectroscopy are also discussed. A new measurement has been proposed for detecting Ξ− C atom X rays, where a novel Ξ− tracking method will be applied to realize an improved signal to noise ratio.
A Skyrme force for 𝚵− hypernuclei
Authors: Schulze Hans-Josef , Guo Jing , Zhou Xian-Rong
Published: November 2022

Experimental data for the cascade hypernuclei 15ΞC, 12ΞBe, and 13ΞB are analyzed within a Skyrme-Hartree-Fock theoretical approach and optimal Skyrme parameters are determined. The important role of deformation for 13ΞB is pointed out. Predictions for 7ΞH and 10ΞLi are made.
High resolution spectroscopy of 𝚵 hypernuclei with active fiber target
Authors: Harada Takeshi K. , Ebata K. , Gogami T. , Hayakawa S. H. , Honda R. , Ichikawa Y. , Miwa K. , Nagae T. , Nanamura T. , Takahashi T. , Ukai M. , Yamamoto T. O.
Published: November 2022

We are planning to carry out a high-resolution spectroscopy of Ξ hypernucleus at the J-PARC K1.8 beamline, which provides a highintensity K− beam (J-PARC E70 experiment). The high-resolution spectroscopy aims to be realized by introducing a new magnetic spectrometer S-2S and an active fiber target AFT. In this article, the role of the AFT in this experiment and its development status are described.
On K−-nuclear interaction, K−-nuclear quasibound states and K− atoms
Authors: Óbertová Jaroslava , Friedman Eliahu , Mareš Jiří , Ramos Àngels
Published: November 2022

The K−N potentials derived from SU(3) chiral coupled-channel meson-baryon interaction models fail to describe kaonic atom data. It was shown that K− single-nucleon potentials have to be supplemented by a phenomenological K− multi-nucleon optical potential in order to achieve good description of the data. Moreover, only the Prague, Kyoto-Munich and Barcelona models are able to account for the experimental data on K− atoms and K− singlenucleon absorption ratios from bubble chamber experiments. A considerable imaginary part coming from the multi-nucleon absorption ruled out existence of narrow K−-nuclear quasibound states in nuclei with A ≥ 6.

We have developed a microscopic model for the K−NN absorption in nuclear matter. The absorption was described as a meson-exchange process and the primary K−N interaction strength was derived from the state-of-the-art chiral models. The medium modifications of the K−N scattering amplitudes due to the Pauli exclusion principle were taken into account. The model was applied in calculations of kaonic atoms for the first time. The description of the data improved significantly when the two nucleon absorption was considered.
Strange hadron correlations in heavy-ion collisions at RHIC energies and below
Authors: Zbroszczyk Hanna
Published: November 2022

Geometry and dynamics of the particle-emitting source in heavy-ion collisions can be inferred via the femtoscopy method. Two-particle correlations at small relative momentum exploit Quantum Statistics and the Final State Interactions (Coulomb and strong), which allow one to study the space-time characteristics of the source of the order of 10−15 m and 10−23 s. Femtoscopic measurements allow one also to study FSI, especially the strong one, which is unknown for many two-particle systems. The RHIC program covers a significant part of the QCD phase diagram using collisions of Au nuclei for several beam energies from 7.7 to 200 GeV for which baryon-rich region is studied via femtoscopy. These measurements complement those obtained from AGS, SPS, and SIS experiments. Strange hadron measurements together with nonstrange ones provide complementary information about source characteristics. Strangeness is a significant observable for many regimes of collision energies providing a complete view of strangeness production in heavy-ion collisions. These proceedings shows the femtoscopic measurements of various strange particle combinations at different collision energies and centralities of the collision.
Effet du vieillissement thermique sur les propriétés structurales et microstructurales d’un alliage à mémoire de forme de type CuZnAl
Authors: Faci Djihade Nesrine , Chouf Saida , Benchiheub Mostepha , Belkahla Soliman
Published: November 2022

Les effets du temps et de la température de vieillissement sur le comportement de la transformation martensitique d’un alliage à mémoire de forme de type CuZnAl à 4 % d’Al ont été étudiés. Les variations des températures de transformation, le changement dans la microstructure, la microdureté en fonction du temps et de la température de vieillissement ont été montrés. Le suivi par DRX d’échantillons vieillis à différentes températures a montré la présence de précipités Cu5Zn8, Al4Cu9, Al2Cu. Cette transformation tend vers le blocage en augmentant le temps de vieillissement. Avec l’augmentation du temps de vieillissement la quantité de précipités augmente considérablement et leur localisation s’étend, au départ, dans les joints de grains puis vers l’intérieur de la matrice en l’envahissant totalement.
Identification and expression profile of odorant-binding proteins in the parasitic wasp Microplitis pallidipes using PacBio long-read sequencing
Authors: Zhang Hao , Wang Jin-Yan , Wan Nian-Feng , Chen Yi-Juan , Ji Xiang-Yun , Jiang Jie-Xian
Published: November 2022

Microplitis pallidipes Szépligeti (Hymenoptera: Braconidae) is an important parasitic wasp of second and third-instar noctuid larvae such as the insect pests Spodoptera exigua, Spodoptera litura, and Spodoptera frugiperda. As in other insects, M. pallidipes has a chemosensory recognition system that is critical to foraging, mating, oviposition, and other behaviors. Odorant-binding proteins (OBPs) are important to the system, but those of M. pallidipes have not been determined. This study used PacBio long-read sequencing to identify 170,980 M. pallidipes unigenes and predicted 129,381 proteins. Following retrieval of possible OBP sequences, we removed those that were redundant or non-full-length and eventually cloned five OBP sequences: MpOBP2, MpOBP3, MpOBP8, MpOBP10, and MpPBP 429, 429, 459, 420, and 429 bp in size, respectively. Each M. pallidipes OBP had six conserved cysteine residues. Phylogenetic analysis revealed that the five OBPs were located at different branches of the phylogenetic tree. Additionally, tissue expression profiles indicated that MpOBP2 and MpPBP were mainly expressed in the antennae of male wasps, while MpOBP3, MpOBP8, and MpOBP10 were mainly expressed in the antennae of female wasps. MpOBP3 was also highly expressed in the legs of female wasps. Temporal profiles revealed that the expression of each M. pallidipes OBP peaked at different days after emergence to adulthood. In conclusion, we identified five novel odorant-binding proteins of M. pallidipes and demonstrated biologically relevant differences in expression patterns.
Risk Factors of Preterm Birth in Women After Local Treatment of Cervical Intraepithelial Neoplasia – a Retrospective Cohort Study
Authors: Stubert Johannes , Stratmann Elisa , Gerber Bernd , Mann Ellen
Published: November 2022

Purpose A previous cervical intraepithelial neoplasia is associated with an increased obstetrical risk. It was the aim of the study to identify risk factors of preterm birth in
patients with cervical intraepithelial neoplasia in dependence of the treatment modality (excisional vs. ablative).

Methods Women with treated cervical intraepithelial neoplasia and subsequent pregnancy (n = 155) were included in this retrospective study. Methods of treatment were either
conization by large loop excision of the transformation zone (LLETZ) or ablative laser vaporization.

Results Of the total population 60.6% (n = 94) had a conization and 39.4% (n = 61) a laser vaporization alone. The frequency of preterm birth < 37 weeks was 9.7% (n = 15) without
differences between conization and laser (11.7 vs. 6.7%, p = 0.407) with an odds ratio (OR) of 1.9 (95% confidence interval [CI] 0.6–6.2). Preterm birth < 34 weeks was found in 2.6%
(n = 4), of which all had a conization (4.3 vs. 0%, p = 0.157). Risk factors for preterm birth were repeated cervical intervention (OR 4.7 [95% CI 1.5–14.3]), especially a combination of
conization and laser ablation (OR 14.9 [95% CI 4.0–55.6]), age at intervention < 30 years (OR 6.0 [95% CI 1.3–27.4]), a history of preterm birth (OR 4.7 [95% CI 1.3–17.6]) and age at
delivery < 28 years (OR 4.7 [95% CI 1.5–14.3]).

Conclusion The large loop excision of the transformation zone as a modern, less invasive ablative treatment did not obviously increase the risk of preterm birth compared to laser
vaporization. The most important risk factor for preterm delivery was the need of a repeated intervention, especially at younger age. We assume that the persistence or recurrence of the
cervical intraepithelial neoplasia following a high-risk human papillomavirus infection is mainly responsible for the observed effect.