bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S1 from TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma
Authors: Goyal Lipika , Shi Lei , Liu Leah Y. , Fece de la Cruz Ferran , Lennerz Jochen K. , Raghavan Srivatsan , Leschiner Ignaty , Elagina Liudmila , Siravegna Giulia , Ng Raymond W.S. , Vu Phuong , Patra Krushna C. , Saha Supriya K. , Uppot Raul N. , Arellano Ron , Reyes Stephanie , Sagara Takeshi , Otsuki Sachie , Nadres Brandon , Shahzade Heather A. , Dey-Guha Ipsita , Fetter Isobel J. , Baiev Islam , Van Seventer Emily E. , Murphy Janet E. , Ferrone Cristina R. , Tanabe Kenneth K. , Deshpande Vikram , Harding James J. , Yaeger Rona , Kelley Robin K. , Bardelli Alberto , Iafrate A. John , Hahn William C. , Benes Cyril H. , Ting David T. , Hirai Hiroshi , Getz Gad , Juric Dejan , Zhu Andrew X. , Corcoran Ryan B. , Bardeesy Nabeel
Published: April 2023

Primer sequences
Figure S1 and S2 from TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma
Authors: Goyal Lipika , Shi Lei , Liu Leah Y. , Fece de la Cruz Ferran , Lennerz Jochen K. , Raghavan Srivatsan , Leschiner Ignaty , Elagina Liudmila , Siravegna Giulia , Ng Raymond W.S. , Vu Phuong , Patra Krushna C. , Saha Supriya K. , Uppot Raul N. , Arellano Ron , Reyes Stephanie , Sagara Takeshi , Otsuki Sachie , Nadres Brandon , Shahzade Heather A. , Dey-Guha Ipsita , Fetter Isobel J. , Baiev Islam , Van Seventer Emily E. , Murphy Janet E. , Ferrone Cristina R. , Tanabe Kenneth K. , Deshpande Vikram , Harding James J. , Yaeger Rona , Kelley Robin K. , Bardelli Alberto , Iafrate A. John , Hahn William C. , Benes Cyril H. , Ting David T. , Hirai Hiroshi , Getz Gad , Juric Dejan , Zhu Andrew X. , Corcoran Ryan B. , Bardeesy Nabeel
Published: April 2023

Supplementary Figures and Legends
Table S4 from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
Authors: Taylor Justin , Sendino Maria , Gorelick Alexander N. , Pastore Alessandro , Chang Matthew T. , Penson Alexander V. , Gavrila Elena I. , Stewart Connor , Melnik Ella M. , Herrejon Chavez Florisela , Bitner Lillian , Yoshimi Akihide , Lee Stanley Chun-Wei , Inoue Daichi , Liu Bo , Zhang Xiao J. , Mato Anthony R. , Dogan Ahmet , Kharas Michael G. , Chen Yuhong , Wang Demin , Soni Rajesh K. , Hendrickson Ronald C. , Prieto Gorka , Rodriguez Jose A. , Taylor Barry S. , Abdel-Wahab Omar
Published: April 2023

Fold-change in abundance and statistical significance of proteins in XPO1E571K/WT versus XPO1WT NALM-6 cells detected by SILAC analysis of nuclear fractions
Table S2 from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
Authors: Taylor Justin , Sendino Maria , Gorelick Alexander N. , Pastore Alessandro , Chang Matthew T. , Penson Alexander V. , Gavrila Elena I. , Stewart Connor , Melnik Ella M. , Herrejon Chavez Florisela , Bitner Lillian , Yoshimi Akihide , Lee Stanley Chun-Wei , Inoue Daichi , Liu Bo , Zhang Xiao J. , Mato Anthony R. , Dogan Ahmet , Kharas Michael G. , Chen Yuhong , Wang Demin , Soni Rajesh K. , Hendrickson Ronald C. , Prieto Gorka , Rodriguez Jose A. , Taylor Barry S. , Abdel-Wahab Omar
Published: April 2023

578 genes sequenced in mouse genomic DNA.
Supplementary Tables and Methods from Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment
Authors: Chen Xufeng , Glytsou Christina , Zhou Hua , Narang Sonali , Reyna Denis E. , Lopez Andrea , Sakellaropoulos Theodore , Gong Yixiao , Kloetgen Andreas , Yap Yoon Sing , Wang Eric , Gavathiotis Evripidis , Tsirigos Aristotelis , Tibes Raoul , Aifantis Iannis
Published: April 2023

Supplementary Tables and Methods
Supplementary Table 3 from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells
Authors: Dixit Deobrat , Prager Briana C. , Gimple Ryan C. , Poh Hui Xian , Wang Yang , Wu Qiulian , Qiu Zhixin , Kidwell Reilly L. , Kim Leo J.Y. , Xie Qi , Vitting-Seerup Kristoffer , Bhargava Shruti , Dong Zhen , Jiang Li , Zhu Zhe , Hamerlik Petra , Jaffrey Samie R. , Zhao Jing Crystal , Wang Xiuxing , Rich Jeremy N.
Published: April 2023

Supplementary Table
Supplementary Table 1 from IFNγ Is Critical for CAR T Cell–Mediated Myeloid Activation and Induction of Endogenous Immunity
Authors: Alizadeh Darya , Wong Robyn A. , Gholamin Sharareh , Maker Madeleine , Aftabizadeh Maryam , Yang Xin , Pecoraro Joseph R. , Jeppson John D. , Wang Dongrui , Aguilar Brenda , Starr Renate , Larmonier Claire B. , Larmonier Nicolas , Chen Min-Hsuan , Wu Xiwei , Ribas Antoni , Badie Behnam , Forman Stephen J. , Brown Christine E.
Published: April 2023

Supplementary Table 1
Supplementary Figures from IFNγ Is Critical for CAR T Cell–Mediated Myeloid Activation and Induction of Endogenous Immunity
Authors: Alizadeh Darya , Wong Robyn A. , Gholamin Sharareh , Maker Madeleine , Aftabizadeh Maryam , Yang Xin , Pecoraro Joseph R. , Jeppson John D. , Wang Dongrui , Aguilar Brenda , Starr Renate , Larmonier Claire B. , Larmonier Nicolas , Chen Min-Hsuan , Wu Xiwei , Ribas Antoni , Badie Behnam , Forman Stephen J. , Brown Christine E.
Published: April 2023

Supplementary Figures S1-S19
Figure S7 from Discovery and Features of an Alkylating Signature in Colorectal Cancer
Authors: Gurjao Carino , Zhong Rong , Haruki Koichiro , Li Yvonne Y. , Spurr Liam F. , Lee-Six Henry , Reardon Brendan , Ugai Tomotaka , Zhang Xuehong , Cherniack Andrew D. , Song Mingyang , Van Allen Eliezer M. , Meyerhardt Jeffrey A. , Nowak Jonathan A. , Giovannucci Edward L. , Fuchs Charles S. , Wu Kana , Ogino Shuji , Giannakis Marios
Published: April 2023

Supplemental Figure 7: Lack of association of the alkylating signature with germline SNPs in BER genes The False Discovery Rate (FDR) adjusted p-value (y axis) for SNPs in each BER (x axis) colored by chromosome location. The blue horizontal line indicates the significance threshold of <0.1. BER: Base Excision Repair
Figure S5 from Discovery and Features of an Alkylating Signature in Colorectal Cancer
Authors: Gurjao Carino , Zhong Rong , Haruki Koichiro , Li Yvonne Y. , Spurr Liam F. , Lee-Six Henry , Reardon Brendan , Ugai Tomotaka , Zhang Xuehong , Cherniack Andrew D. , Song Mingyang , Van Allen Eliezer M. , Meyerhardt Jeffrey A. , Nowak Jonathan A. , Giovannucci Edward L. , Fuchs Charles S. , Wu Kana , Ogino Shuji , Giannakis Marios
Published: April 2023

Supplemental Figure 5: Comparison between SigProfiler and standard NMF approach for TCGA Rank survey (left panels) and cosine similarity heatmaps between SigProfiler and standard NMF signatures (right panels) in TCGA.
Figure S2 from Discovery and Features of an Alkylating Signature in Colorectal Cancer
Authors: Gurjao Carino , Zhong Rong , Haruki Koichiro , Li Yvonne Y. , Spurr Liam F. , Lee-Six Henry , Reardon Brendan , Ugai Tomotaka , Zhang Xuehong , Cherniack Andrew D. , Song Mingyang , Van Allen Eliezer M. , Meyerhardt Jeffrey A. , Nowak Jonathan A. , Giovannucci Edward L. , Fuchs Charles S. , Wu Kana , Ogino Shuji , Giannakis Marios
Published: April 2023

Supplemental Figure 2: Comparison between SigProfiler and standard NMF approach for NHS/ HPFS Rank survey (left panels) and cosine similarity heatmaps between SigProfiler and standard NMF signatures (right panels) in NHS/ HPFS.
Figure S10 from Discovery and Features of an Alkylating Signature in Colorectal Cancer
Authors: Gurjao Carino , Zhong Rong , Haruki Koichiro , Li Yvonne Y. , Spurr Liam F. , Lee-Six Henry , Reardon Brendan , Ugai Tomotaka , Zhang Xuehong , Cherniack Andrew D. , Song Mingyang , Van Allen Eliezer M. , Meyerhardt Jeffrey A. , Nowak Jonathan A. , Giovannucci Edward L. , Fuchs Charles S. , Wu Kana , Ogino Shuji , Giannakis Marios
Published: April 2023

Supplemental Figure 10: Alkylating signature and lifestyle factors Proportion of mutations assigned to alkylating damage in NHS/ HPFS, segregated by alcohol consumption (alcohol consumption versus none), smoking (current or former smoker vs never smoker, obesity (BMI {greater than or equal to} 30 versus BMI < 30) and physical activity [Metabolic equivalent of task (METS)-hours/week {greater than or equal to} 10 versus < 10]. The two-sided Mann-Whitney test p-value is indicated. BMI: Body Mass Index.
Supplementary Tables S1-S4 from Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Authors: Venkatesan Subramanian , Angelova Mihaela , Puttick Clare , Zhai Haoran , Caswell Deborah R. , Lu Wei-Ting , Dietzen Michelle , Galanos Panagiotis , Evangelou Konstantinos , Bellelli Roberto , Lim Emilia L. , Watkins Thomas B.K. , Rowan Andrew , Teixeira Vitor H. , Zhao Yue , Chen Haiquan , Ngo Bryan , Zalmas Lykourgos-Panagiotis , Al Bakir Maise , Hobor Sebastijan , Grönroos Eva , Pennycuick Adam , Nigro Ersilia , Campbell Brittany B. , Brown William L. , Akarca Ayse U. , Marafioti Teresa , Wu Mary Y. , Howell Michael , Boulton Simon J. , Bertoli Cosetta , Fenton Tim R. , de Bruin Robertus A.M. , Maya-Mendoza Apolinar , Santoni-Rugiu Eric , Hynds Robert E. , Gorgoulis Vassilis G. , Jamal-Hanjani Mariam , McGranahan Nicholas , Harris Reuben S. , Janes Sam M. , Bartkova Jirina , Bakhoum Samuel F. , Bartek Jiri , Kanu Nnennaya , Swanton Charles
Published: April 2023

Supplementary Table 1: Overview of data resource. Supplementary Table 2: List of antibodies used for immunofluorescence. Supplementary Table 3: List of antibodies used for western blotting. Supplementary Table 4. List of primers used for PCR.
Supplementary Figure 3 from Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Authors: Venkatesan Subramanian , Angelova Mihaela , Puttick Clare , Zhai Haoran , Caswell Deborah R. , Lu Wei-Ting , Dietzen Michelle , Galanos Panagiotis , Evangelou Konstantinos , Bellelli Roberto , Lim Emilia L. , Watkins Thomas B.K. , Rowan Andrew , Teixeira Vitor H. , Zhao Yue , Chen Haiquan , Ngo Bryan , Zalmas Lykourgos-Panagiotis , Al Bakir Maise , Hobor Sebastijan , Grönroos Eva , Pennycuick Adam , Nigro Ersilia , Campbell Brittany B. , Brown William L. , Akarca Ayse U. , Marafioti Teresa , Wu Mary Y. , Howell Michael , Boulton Simon J. , Bertoli Cosetta , Fenton Tim R. , de Bruin Robertus A.M. , Maya-Mendoza Apolinar , Santoni-Rugiu Eric , Hynds Robert E. , Gorgoulis Vassilis G. , Jamal-Hanjani Mariam , McGranahan Nicholas , Harris Reuben S. , Janes Sam M. , Bartkova Jirina , Bakhoum Samuel F. , Bartek Jiri , Kanu Nnennaya , Swanton Charles
Published: April 2023

Generation and characterization of A3A and A3B knockouts in TIIP cells.
Supplementary Figure 2 from Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Authors: Venkatesan Subramanian , Angelova Mihaela , Puttick Clare , Zhai Haoran , Caswell Deborah R. , Lu Wei-Ting , Dietzen Michelle , Galanos Panagiotis , Evangelou Konstantinos , Bellelli Roberto , Lim Emilia L. , Watkins Thomas B.K. , Rowan Andrew , Teixeira Vitor H. , Zhao Yue , Chen Haiquan , Ngo Bryan , Zalmas Lykourgos-Panagiotis , Al Bakir Maise , Hobor Sebastijan , Grönroos Eva , Pennycuick Adam , Nigro Ersilia , Campbell Brittany B. , Brown William L. , Akarca Ayse U. , Marafioti Teresa , Wu Mary Y. , Howell Michael , Boulton Simon J. , Bertoli Cosetta , Fenton Tim R. , de Bruin Robertus A.M. , Maya-Mendoza Apolinar , Santoni-Rugiu Eric , Hynds Robert E. , Gorgoulis Vassilis G. , Jamal-Hanjani Mariam , McGranahan Nicholas , Harris Reuben S. , Janes Sam M. , Bartkova Jirina , Bakhoum Samuel F. , Bartek Jiri , Kanu Nnennaya , Swanton Charles
Published: April 2023

APOBEC3 gene expression during senescence and cell cycle progression.
Supplementary Table S3 from Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy
Authors: DeStefano Shields Christina E. , White James R. , Chung Liam , Wenzel Alyssa , Hicks Jessica L. , Tam Ada J. , Chan June L. , Dejea Christine M. , Fan Hongni , Michel John , Maiuri Ashley R. , Sriramkumar Shruthi , Podicheti Ram , Rusch Douglas B. , Wang Hao , De Marzo Angelo M. , Besharati Sepideh , Anders Robert A. , Baylin Stephen B. , O'Hagan Heather M. , Housseau Franck , Sears Cynthia L.
Published: April 2023

Differential expression (DESeq2) tables of RNAseq analysis for sham and ETBF-colonized normal epithelium and tumors from Min and BRAFV600ELgr5CreMin (BLM) colons.
Table S4 from Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade
Authors: Gu Shengqing Stan , Zhang Wubing , Wang Xiaoqing , Jiang Peng , Traugh Nicole , Li Ziyi , Meyer Clifford , Stewig Blair , Xie Yingtian , Bu Xia , Manos Michael P. , Font-Tello Alba , Gjini Evisa , Lako Ana , Lim Klothilda , Conway Jake , Tewari Alok K. , Zeng Zexian , Sahu Avinash Das , Tokheim Collin , Weirather Jason L. , Fu Jingxin , Zhang Yi , Kroger Benjamin , Liang Jin Hua , Cejas Paloma , Freeman Gordon J. , Rodig Scott , Long Henry W. , Gewurz Benjamin E. , Hodi F. Stephen , Brown Myles , Liu X. Shirley
Published: April 2023

RNA-seq and H3K27ac ChIP-seq of MHC-I-high and MHC-I-low primary melanoma samples
Supplementary Figures from AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia
Authors: Tirado-Gonzalez Irene , Descot Arnaud , Soetopo Devona , Nevmerzhitskaya Aleksandra , Schäffer Alexander , Kur Ivan-Maximilano , Czlonka Ewelina , Wachtel Carolin , Tsoukala Ioanna , Müller Luise , Schäfer Anna-Lena , Weitmann Maresa , Dinse Petra , Alberto Emily , Buck Michèle C. , Landry Jonathan JM. , Baying Bianka , Slotta-Huspenina Julia , Roesler Jenny , Harter Patrick N. , Kubasch Anne-Sophie , Meinel Jörn , Elwakeel Eiman , Strack Elisabeth , Quang Christine Tran , Abdel-Wahab Omar , Schmitz Marc , Weigert Andreas , Schmid Tobias , Platzbecker Uwe , Benes Vladimir , Ghysdael Jacques , Bonig Halvard , Götze Katharina S. , Rothlin Carla V. , Ghosh Sourav , Medyouf Hind
Published: April 2023

Supplementary Figures and Figure legends
Figure S4 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
Authors: Pikman Yana , Tasian Sarah K. , Sulis Maria Luisa , Stevenson Kristen , Blonquist Traci M. , Apsel Winger Beth , Cooper Todd M. , Pauly Melinda , Maloney Kelly W. , Burke Michael J. , Brown Patrick A. , Gossai Nathan , McNeer Jennifer L. , Shukla Neerav N. , Cole Peter D. , Kahn Justine M. , Chen Jing , Barth Matthew J. , Magee Jeffrey A. , Gennarini Lisa , Adhav Asmani A. , Clinton Catherine M. , Ocasio-Martinez Nicole , Gotti Giacomo , Li Yuting , Lin Shan , Imamovic Alma , Tognon Cristina E. , Patel Tasleema , Faust Haley L. , Contreras Cristina F. , Cremer Anjali , Cortopassi Wilian A. , Garrido Ruiz Diego , Jacobson Matthew P. , Dharia Neekesh V. , Su Angela , Robichaud Amanda L. , Saur Conway Amy , Tarlock Katherine , Stieglitz Elliot , Place Andrew E. , Puissant Alexandre , Hunger Stephen P. , Kim Annette S. , Lindeman Neal I. , Gore Lia , Janeway Katherine A. , Silverman Lewis B. , Tyner Jeffrey W. , Harris Marian H. , Loh Mignon L. , Stegmaier Kimberly
Published: April 2023

combination of MEK inhibitor with venetoclax is synergistic.
Figure S2 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
Authors: Pikman Yana , Tasian Sarah K. , Sulis Maria Luisa , Stevenson Kristen , Blonquist Traci M. , Apsel Winger Beth , Cooper Todd M. , Pauly Melinda , Maloney Kelly W. , Burke Michael J. , Brown Patrick A. , Gossai Nathan , McNeer Jennifer L. , Shukla Neerav N. , Cole Peter D. , Kahn Justine M. , Chen Jing , Barth Matthew J. , Magee Jeffrey A. , Gennarini Lisa , Adhav Asmani A. , Clinton Catherine M. , Ocasio-Martinez Nicole , Gotti Giacomo , Li Yuting , Lin Shan , Imamovic Alma , Tognon Cristina E. , Patel Tasleema , Faust Haley L. , Contreras Cristina F. , Cremer Anjali , Cortopassi Wilian A. , Garrido Ruiz Diego , Jacobson Matthew P. , Dharia Neekesh V. , Su Angela , Robichaud Amanda L. , Saur Conway Amy , Tarlock Katherine , Stieglitz Elliot , Place Andrew E. , Puissant Alexandre , Hunger Stephen P. , Kim Annette S. , Lindeman Neal I. , Gore Lia , Janeway Katherine A. , Silverman Lewis B. , Tyner Jeffrey W. , Harris Marian H. , Loh Mignon L. , Stegmaier Kimberly
Published: April 2023

Correlation between Ras pathway mutation VAF and in vitro sensitivity to MEK inhibitors.
Figure S1 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
Authors: Pikman Yana , Tasian Sarah K. , Sulis Maria Luisa , Stevenson Kristen , Blonquist Traci M. , Apsel Winger Beth , Cooper Todd M. , Pauly Melinda , Maloney Kelly W. , Burke Michael J. , Brown Patrick A. , Gossai Nathan , McNeer Jennifer L. , Shukla Neerav N. , Cole Peter D. , Kahn Justine M. , Chen Jing , Barth Matthew J. , Magee Jeffrey A. , Gennarini Lisa , Adhav Asmani A. , Clinton Catherine M. , Ocasio-Martinez Nicole , Gotti Giacomo , Li Yuting , Lin Shan , Imamovic Alma , Tognon Cristina E. , Patel Tasleema , Faust Haley L. , Contreras Cristina F. , Cremer Anjali , Cortopassi Wilian A. , Garrido Ruiz Diego , Jacobson Matthew P. , Dharia Neekesh V. , Su Angela , Robichaud Amanda L. , Saur Conway Amy , Tarlock Katherine , Stieglitz Elliot , Place Andrew E. , Puissant Alexandre , Hunger Stephen P. , Kim Annette S. , Lindeman Neal I. , Gore Lia , Janeway Katherine A. , Silverman Lewis B. , Tyner Jeffrey W. , Harris Marian H. , Loh Mignon L. , Stegmaier Kimberly
Published: April 2023

VAF concordance
Supplementary Tables from A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy
Authors: Sanmamed Miguel F. , Nie Xinxin , Desai Shruti S. , Villaroel-Espindola Franz , Badri Ti , Zhao Dejian , Kim Anthony W. , Ji Lan , Zhang Tianxiang , Quinlan Edward , Cheng Xiaoxiao , Han Xue , Vesely Matthew D. , Nassar Ala F. , Sun Jingwei , Zhang Yu , Kim Tae Kon , Wang Jun , Melero Ignacio , Herbst Roy S. , Schalper Kurt A. , Chen Lieping
Published: April 2023

Supplementary Tables S1-5
Supplementary Video 1 from Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling
Authors: Adamopoulos Christos , Ahmed Tamer A. , Tucker Maxwell R. , Ung Peter M.U. , Xiao Min , Karoulia Zoi , Amabile Angelo , Wu Xuewei , Aaronson Stuart A. , Ang Celina , Rebecca Vito W. , Brown Brian D. , Schlessinger Avner , Herlyn Meenhard , Wang Qi , Shaw David E. , Poulikakos Poulikos I.
Published: April 2023

Supplementary Video 1
Supplementary Table S8 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Authors: Pore Nabendu , Wu Song , Standifer Nathan , Jure-Kunkel Maria , de los Reyes Melissa , Shrestha Yashaswi , Halpin Rebecca , Rothstein Raymond , Mulgrew Kathy , Blackmore Stephen , Martin Philip , Meekin John , Griffin Matthew , Bisha Ina , Proia Theresa A. , Miragaia Ricardo J. , Herbst Ronald , Gupta Ashok , Abdullah Shaad E. , Raja Rajiv , Frigault Melanie M. , Barrett J. Carl , Dennis Phillip A. , Ascierto Maria Libera , Oberst Michael D.
Published: April 2023

Kaplan-Meier analysis using a log rank (Mantel-Cox) test to compare survival among the treatment groups represented in Figure 5. A total of 9 comparisons between groups were conducted. P-values were not adjusted for multiple comparisons.
Supplementary Table S4 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Authors: Pore Nabendu , Wu Song , Standifer Nathan , Jure-Kunkel Maria , de los Reyes Melissa , Shrestha Yashaswi , Halpin Rebecca , Rothstein Raymond , Mulgrew Kathy , Blackmore Stephen , Martin Philip , Meekin John , Griffin Matthew , Bisha Ina , Proia Theresa A. , Miragaia Ricardo J. , Herbst Ronald , Gupta Ashok , Abdullah Shaad E. , Raja Rajiv , Frigault Melanie M. , Barrett J. Carl , Dennis Phillip A. , Ascierto Maria Libera , Oberst Michael D.
Published: April 2023

Marker genes for the main CD45+ cell populations identified in Supplementary Figure 5. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on Wilcoxon test; avg_logFC, log fold-change of the average expression between the given cluster and all other clusters; pct.1, fraction of gene-expressing cells in the given cluster; pct.2, fraction of gene-expressing cells in all other clusters; pct.diff, Difference between the percentage of gene-expressing cells in the given cluster and all other clusters; p_val_adj, Bonferroni adjusted p-value; cluster, cluster annotation based on the gene markers identified; resolution, clustering resolution parameter used in Seurat.
Supplementary Table S3 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Authors: Pore Nabendu , Wu Song , Standifer Nathan , Jure-Kunkel Maria , de los Reyes Melissa , Shrestha Yashaswi , Halpin Rebecca , Rothstein Raymond , Mulgrew Kathy , Blackmore Stephen , Martin Philip , Meekin John , Griffin Matthew , Bisha Ina , Proia Theresa A. , Miragaia Ricardo J. , Herbst Ronald , Gupta Ashok , Abdullah Shaad E. , Raja Rajiv , Frigault Melanie M. , Barrett J. Carl , Dennis Phillip A. , Ascierto Maria Libera , Oberst Michael D.
Published: April 2023

Cytokines and other soluble factors evaluated in the baseline serum of patients with STK11mut or STK11wt tumors.
Supplementary Table S2 from Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level
Authors: Wu Yingcheng , Yang Shuaixi , Ma Jiaqiang , Chen Zechuan , Song Guohe , Rao Dongning , Cheng Yifei , Huang Siyuan , Liu Yifei , Jiang Shan , Liu Jinxia , Huang Xiaowu , Wang Xiaoying , Qiu Shuangjian , Xu Jianmin , Xi Ruibin , Bai Fan , Zhou Jian , Fan Jia , Zhang Xiaoming , Gao Qiang
Published: April 2023

Supplementary Table S2. Marker genes for all immune cell subsets.
Supplementary Figure S13 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Authors: Pore Nabendu , Wu Song , Standifer Nathan , Jure-Kunkel Maria , de los Reyes Melissa , Shrestha Yashaswi , Halpin Rebecca , Rothstein Raymond , Mulgrew Kathy , Blackmore Stephen , Martin Philip , Meekin John , Griffin Matthew , Bisha Ina , Proia Theresa A. , Miragaia Ricardo J. , Herbst Ronald , Gupta Ashok , Abdullah Shaad E. , Raja Rajiv , Frigault Melanie M. , Barrett J. Carl , Dennis Phillip A. , Ascierto Maria Libera , Oberst Michael D.
Published: April 2023

Suppressive activity of MDSCs isolated from CT26 WT or CT26 SKT11 KO tumors and pharmacological reversal by STAT3 ASO treatment in the CT26 WT model. (A) Percentage of naive T cell proliferation by anti-CD3/CD28/IL2 stimulation in the presence of Gr1+ MDSCs isolated from CT26 WT or CT26 STK11 KO tumors (left), as indicated. Error bars represent SEM from technical replicates of MDSCs pooled from multiple tumors. P-values calculated using two-tailed Student's T test. Proliferation of non-stimulated T cells and anti-CD3/CD28/IL2-stimulated T cells used as controls in the assay are also shown (right). (B) Percentage T cell proliferation when co-cultured with MDSCs from mice engrafted with CT26 WT tumors and administered either CPIs and/or STAT3 ASO, or isotype control antibodies, as indicated. The x-axis represents the MDSC:T cell ratio in the assay. The proliferation of the non-stimulated T cells and anti-CD3/CD28/IL2-stimulated T cells which were used as controls in the assay is also shown.
Supplementary Figure 7 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Authors: Lo Yuan-Hung , Kolahi Kevin S. , Du Yuhong , Chang Chiung-Ying , Krokhotin Andrey , Nair Ajay , Sobba Walter D. , Karlsson Kasper , Jones Sunny J. , Longacre Teri A. , Mah Amanda T. , Tercan Bahar , Sockell Alexandra , Xu Hang , Seoane Jose A. , Chen Jin , Shmulevich Ilya , Weissman Jonathan S. , Curtis Christina , Califano Andrea , Fu Haian , Crabtree Gerald R. , Kuo Calvin J.
Published: April 2023

Supplementary Figure 7
Supplementary Figure 6 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Authors: Lo Yuan-Hung , Kolahi Kevin S. , Du Yuhong , Chang Chiung-Ying , Krokhotin Andrey , Nair Ajay , Sobba Walter D. , Karlsson Kasper , Jones Sunny J. , Longacre Teri A. , Mah Amanda T. , Tercan Bahar , Sockell Alexandra , Xu Hang , Seoane Jose A. , Chen Jin , Shmulevich Ilya , Weissman Jonathan S. , Curtis Christina , Califano Andrea , Fu Haian , Crabtree Gerald R. , Kuo Calvin J.
Published: April 2023

Supplementary Figure 6
Supplementary Figure 4 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Authors: Lo Yuan-Hung , Kolahi Kevin S. , Du Yuhong , Chang Chiung-Ying , Krokhotin Andrey , Nair Ajay , Sobba Walter D. , Karlsson Kasper , Jones Sunny J. , Longacre Teri A. , Mah Amanda T. , Tercan Bahar , Sockell Alexandra , Xu Hang , Seoane Jose A. , Chen Jin , Shmulevich Ilya , Weissman Jonathan S. , Curtis Christina , Califano Andrea , Fu Haian , Crabtree Gerald R. , Kuo Calvin J.
Published: April 2023

Supplementary Figure 4
Supplementary Tables and Figures from Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor–Resistant, EGFR-Mutated Non–Small Cell Lung Cancer
Authors: Jänne Pasi A. , Baik Christina , Su Wu-Chou , Johnson Melissa L. , Hayashi Hidetoshi , Nishio Makoto , Kim Dong-Wan , Koczywas Marianna , Gold Kathryn A. , Steuer Conor E. , Murakami Haruyasu , Yang James Chih-Hsin , Kim Sang-We , Vigliotti Michele , Shi Rong , Qi Zhenhao , Qiu Yang , Zhao Lihui , Sternberg David , Yu Channing , Yu Helena A.
Published: April 2023

Supplementary Tables and Figures from Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor–Resistant, EGFR-Mutated Non–Small Cell Lung Cancer
Supplementary Tables S1-S7 from Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers
Authors: Horak Peter , Heining Christoph , Kreutzfeldt Simon , Hutter Barbara , Mock Andreas , Hüllein Jennifer , Fröhlich Martina , Uhrig Sebastian , Jahn Arne , Rump Andreas , Gieldon Laura , Möhrmann Lino , Hanf Dorothea , Teleanu Veronica , Heilig Christoph E. , Lipka Daniel B. , Allgäuer Michael , Ruhnke Leo , Laßmann Andreas , Endris Volker , Neumann Olaf , Penzel Roland , Beck Katja , Richter Daniela , Winter Ulrike , Wolf Stephan , Pfütze Katrin , Geörg Christina , Meißburger Bettina , Buchhalter Ivo , Augustin Marinela , Aulitzky Walter E. , Hohenberger Peter , Kroiss Matthias , Schirmacher Peter , Schlenk Richard F. , Keilholz Ulrich , Klauschen Frederick , Folprecht Gunnar , Bauer Sebastian , Siveke Jens Thomas , Brandts Christian H. , Kindler Thomas , Boerries Melanie , Illert Anna L. , von Bubnoff Nikolas , Jost Philipp J. , Spiekermann Karsten , Bitzer Michael , Schulze-Osthoff Klaus , von Kalle Christof , Klink Barbara , Brors Benedikt , Stenzinger Albrecht , Schröck Evelin , Hübschmann Daniel , Weichert Wilko , Glimm Hanno , Fröhling Stefan
Published: April 2023

This excel file contains supplementary tables S1-S7.
Supplementary Methods from Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers
Authors: Horak Peter , Heining Christoph , Kreutzfeldt Simon , Hutter Barbara , Mock Andreas , Hüllein Jennifer , Fröhlich Martina , Uhrig Sebastian , Jahn Arne , Rump Andreas , Gieldon Laura , Möhrmann Lino , Hanf Dorothea , Teleanu Veronica , Heilig Christoph E. , Lipka Daniel B. , Allgäuer Michael , Ruhnke Leo , Laßmann Andreas , Endris Volker , Neumann Olaf , Penzel Roland , Beck Katja , Richter Daniela , Winter Ulrike , Wolf Stephan , Pfütze Katrin , Geörg Christina , Meißburger Bettina , Buchhalter Ivo , Augustin Marinela , Aulitzky Walter E. , Hohenberger Peter , Kroiss Matthias , Schirmacher Peter , Schlenk Richard F. , Keilholz Ulrich , Klauschen Frederick , Folprecht Gunnar , Bauer Sebastian , Siveke Jens Thomas , Brandts Christian H. , Kindler Thomas , Boerries Melanie , Illert Anna L. , von Bubnoff Nikolas , Jost Philipp J. , Spiekermann Karsten , Bitzer Michael , Schulze-Osthoff Klaus , von Kalle Christof , Klink Barbara , Brors Benedikt , Stenzinger Albrecht , Schröck Evelin , Hübschmann Daniel , Weichert Wilko , Glimm Hanno , Fröhling Stefan
Published: April 2023

This file contains supplementary methods and references.
Supplementary Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Authors: McLeod Clay , Gout Alexander M. , Zhou Xin , Thrasher Andrew , Rahbarinia Delaram , Brady Samuel W. , Macias Michael , Birch Kirby , Finkelstein David , Sunny Jobin , Mudunuri Rahul , Orr Brent A. , Treadway Madison , Davidson Bob , Ard Tracy K. , Chiao Arthur , Swistak Andrew , Wiggins Stephanie , Foy Scott , Wang Jian , Sioson Edgar , Wang Shuoguo , Michael J. Robert , Liu Yu , Ma Xiaotu , Patel Aman , Edmonson Michael N. , Wilkinson Mark R. , Frantz Andrew M. , Chang Ti-Cheng , Tian Liqing , Lei Shaohua , Islam S.M. Ashiqul , Meyer Christopher , Thangaraj Naina , Tater Pamella , Kandali Vijay , Ma Singer , Nguyen Tuan , Serang Omar , McGuire Irina , Robison Nedra , Gentry Darrell , Tang Xing , Palmer Lance E. , Wu Gang , Suh Ed , Tanner Leigh , McMurry James , Lear Matthew , Pappo Alberto S. , Wang Zhaoming , Wilson Carmen L. , Cheng Yong , Meshinchi Soheil , Alexandrov Ludmil B. , Weiss Mitchell J. , Armstrong Gregory T. , Robison Leslie L. , Yasui Yutaka , Nichols Kim E. , Ellison David W. , Bangur Chaitanya , Mullighan Charles G. , Baker Suzanne J. , Dyer Michael A. , Miller Geralyn , Newman Scott , Rusch Michael , Daly Richard , Perry Keith , Downing James R. , Zhang Jinghui
Published: April 2023

Involves Supplementary Table Legends and Supplementary Figures and associated legends
Supplementary Tables from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing
Authors: Newman Scott , Nakitandwe Joy , Kesserwan Chimene A. , Azzato Elizabeth M. , Wheeler David A. , Rusch Michael , Shurtleff Sheila , Hedges Dale J. , Hamilton Kayla V. , Foy Scott G. , Edmonson Michael N. , Thrasher Andrew , Bahrami Armita , Orr Brent A. , Klco Jeffery M. , Gu Jiali , Harrison Lynn W. , Wang Lu , Clay Michael R. , Ouma Annastasia , Silkov Antonina , Liu Yanling , Zhang Zhaojie , Liu Yu , Brady Samuel W. , Zhou Xin , Chang Ti-Cheng , Pande Manjusha , Davis Eric , Becksfort Jared , Patel Aman , Wilkinson Mark R. , Rahbarinia Delaram , Kubal Manish , Maciaszek Jamie L. , Pastor Victor , Knight Jay , Gout Alexander M. , Wang Jian , Gu Zhaohui , Mullighan Charles G. , McGee Rose B. , Quinn Emily A. , Nuccio Regina , Mostafavi Roya , Gerhardt Elsie L. , Taylor Leslie M. , Valdez Jessica M. , Hines-Dowell Stacy J. , Pappo Alberto S. , Robinson Giles , Johnson Liza-Marie , Pui Ching-Hon , Ellison David W. , Downing James R. , Zhang Jinghui , Nichols Kim E.
Published: April 2023

Supplementary Tables S1-S17
Supplementary Figure S7 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing
Authors: Newman Scott , Nakitandwe Joy , Kesserwan Chimene A. , Azzato Elizabeth M. , Wheeler David A. , Rusch Michael , Shurtleff Sheila , Hedges Dale J. , Hamilton Kayla V. , Foy Scott G. , Edmonson Michael N. , Thrasher Andrew , Bahrami Armita , Orr Brent A. , Klco Jeffery M. , Gu Jiali , Harrison Lynn W. , Wang Lu , Clay Michael R. , Ouma Annastasia , Silkov Antonina , Liu Yanling , Zhang Zhaojie , Liu Yu , Brady Samuel W. , Zhou Xin , Chang Ti-Cheng , Pande Manjusha , Davis Eric , Becksfort Jared , Patel Aman , Wilkinson Mark R. , Rahbarinia Delaram , Kubal Manish , Maciaszek Jamie L. , Pastor Victor , Knight Jay , Gout Alexander M. , Wang Jian , Gu Zhaohui , Mullighan Charles G. , McGee Rose B. , Quinn Emily A. , Nuccio Regina , Mostafavi Roya , Gerhardt Elsie L. , Taylor Leslie M. , Valdez Jessica M. , Hines-Dowell Stacy J. , Pappo Alberto S. , Robinson Giles , Johnson Liza-Marie , Pui Ching-Hon , Ellison David W. , Downing James R. , Zhang Jinghui , Nichols Kim E.
Published: April 2023

Supplementary Figure S7
Figure S1-6 from Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC
Authors: Tang Kwan Ho , Li Shuai , Khodadadi-Jamayran Alireza , Jen Jayu , Han Han , Guidry Kayla , Chen Ting , Hao Yuan , Fedele Carmine , Zebala John A. , Maeda Dean Y. , Christensen James G. , Olson Peter , Athanas Argus , Loomis Cynthia A. , Tsirigos Aristotelis , Wong Kwok-Kin , Neel Benjamin G.
Published: April 2023

Figure S1-6
Supplementary Figure S6 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing
Authors: Newman Scott , Nakitandwe Joy , Kesserwan Chimene A. , Azzato Elizabeth M. , Wheeler David A. , Rusch Michael , Shurtleff Sheila , Hedges Dale J. , Hamilton Kayla V. , Foy Scott G. , Edmonson Michael N. , Thrasher Andrew , Bahrami Armita , Orr Brent A. , Klco Jeffery M. , Gu Jiali , Harrison Lynn W. , Wang Lu , Clay Michael R. , Ouma Annastasia , Silkov Antonina , Liu Yanling , Zhang Zhaojie , Liu Yu , Brady Samuel W. , Zhou Xin , Chang Ti-Cheng , Pande Manjusha , Davis Eric , Becksfort Jared , Patel Aman , Wilkinson Mark R. , Rahbarinia Delaram , Kubal Manish , Maciaszek Jamie L. , Pastor Victor , Knight Jay , Gout Alexander M. , Wang Jian , Gu Zhaohui , Mullighan Charles G. , McGee Rose B. , Quinn Emily A. , Nuccio Regina , Mostafavi Roya , Gerhardt Elsie L. , Taylor Leslie M. , Valdez Jessica M. , Hines-Dowell Stacy J. , Pappo Alberto S. , Robinson Giles , Johnson Liza-Marie , Pui Ching-Hon , Ellison David W. , Downing James R. , Zhang Jinghui , Nichols Kim E.
Published: April 2023

Supplementary Figure S6
Supplementary Figure S4 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing
Authors: Newman Scott , Nakitandwe Joy , Kesserwan Chimene A. , Azzato Elizabeth M. , Wheeler David A. , Rusch Michael , Shurtleff Sheila , Hedges Dale J. , Hamilton Kayla V. , Foy Scott G. , Edmonson Michael N. , Thrasher Andrew , Bahrami Armita , Orr Brent A. , Klco Jeffery M. , Gu Jiali , Harrison Lynn W. , Wang Lu , Clay Michael R. , Ouma Annastasia , Silkov Antonina , Liu Yanling , Zhang Zhaojie , Liu Yu , Brady Samuel W. , Zhou Xin , Chang Ti-Cheng , Pande Manjusha , Davis Eric , Becksfort Jared , Patel Aman , Wilkinson Mark R. , Rahbarinia Delaram , Kubal Manish , Maciaszek Jamie L. , Pastor Victor , Knight Jay , Gout Alexander M. , Wang Jian , Gu Zhaohui , Mullighan Charles G. , McGee Rose B. , Quinn Emily A. , Nuccio Regina , Mostafavi Roya , Gerhardt Elsie L. , Taylor Leslie M. , Valdez Jessica M. , Hines-Dowell Stacy J. , Pappo Alberto S. , Robinson Giles , Johnson Liza-Marie , Pui Ching-Hon , Ellison David W. , Downing James R. , Zhang Jinghui , Nichols Kim E.
Published: April 2023

Supplementary Figure S4
Table S7 from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence
Authors: Duy Cihangir , Li Meng , Teater Matt , Meydan Cem , Garrett-Bakelman Francine E. , Lee Tak C. , Chin Christopher R. , Durmaz Ceyda , Kawabata Kimihito C. , Dhimolea Eugen , Mitsiades Constantine S. , Doehner Hartmut , D'Andrea Richard J. , Becker Michael W. , Paietta Elisabeth M. , Mason Christopher E. , Carroll Martin , Melnick Ari M.
Published: April 2023

Patient information of samples used in experiments
Table S2 from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence
Authors: Duy Cihangir , Li Meng , Teater Matt , Meydan Cem , Garrett-Bakelman Francine E. , Lee Tak C. , Chin Christopher R. , Durmaz Ceyda , Kawabata Kimihito C. , Dhimolea Eugen , Mitsiades Constantine S. , Doehner Hartmut , D'Andrea Richard J. , Becker Michael W. , Paietta Elisabeth M. , Mason Christopher E. , Carroll Martin , Melnick Ari M.
Published: April 2023

AraC-induded differentially expressed genes after 24hrs
Supplementary figures and figure legends from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Authors: Zhang Qianfei , Ma Chi , Duan Yi , Heinrich Bernd , Rosato Umberto , Diggs Laurence P. , Ma Lichun , Roy Soumen , Fu Qiong , Brown Zachary J. , Wabitsch Simon , Thovarai Vishal , Fu Jianyang , Feng Dechun , Ruf Benjamin , Cui Linda L. , Subramanyam Varun , Frank Karen M. , Wang Sophie , Kleiner David E. , Ritz Thomas , Rupp Christian , Gao Bin , Longerich Thomas , Kroemer Alexander , Wang Xin Wei , Ruchirawat Mathuros , Korangy Firouzeh , Schnabl Bernd , Trinchieri Giorgio , Greten Tim F.
Published: April 2023

Supplementary figures and figure legends
Supplementary Table S6 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Authors: Zhang Qianfei , Ma Chi , Duan Yi , Heinrich Bernd , Rosato Umberto , Diggs Laurence P. , Ma Lichun , Roy Soumen , Fu Qiong , Brown Zachary J. , Wabitsch Simon , Thovarai Vishal , Fu Jianyang , Feng Dechun , Ruf Benjamin , Cui Linda L. , Subramanyam Varun , Frank Karen M. , Wang Sophie , Kleiner David E. , Ritz Thomas , Rupp Christian , Gao Bin , Longerich Thomas , Kroemer Alexander , Wang Xin Wei , Ruchirawat Mathuros , Korangy Firouzeh , Schnabl Bernd , Trinchieri Giorgio , Greten Tim F.
Published: April 2023

MDSC signiture genes
Supplementary Table S1 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Authors: Zhang Qianfei , Ma Chi , Duan Yi , Heinrich Bernd , Rosato Umberto , Diggs Laurence P. , Ma Lichun , Roy Soumen , Fu Qiong , Brown Zachary J. , Wabitsch Simon , Thovarai Vishal , Fu Jianyang , Feng Dechun , Ruf Benjamin , Cui Linda L. , Subramanyam Varun , Frank Karen M. , Wang Sophie , Kleiner David E. , Ritz Thomas , Rupp Christian , Gao Bin , Longerich Thomas , Kroemer Alexander , Wang Xin Wei , Ruchirawat Mathuros , Korangy Firouzeh , Schnabl Bernd , Trinchieri Giorgio , Greten Tim F.
Published: April 2023

LD1 CNV_Sequencing
Supplementary Figure S7 from MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING
Authors: Zhang Yong , Yang Qifan , Zeng Xiangyu , Wang Manxiang , Dong Shuang , Yang Bin , Tu Xinyi , Wei Ting , Xie Wenzhuan , Zhang Chao , Guo Qiang , Kloeber Jake A. , Cao Yueyu , Guo Guijie , Zhou Qin , Zhao Fei , Huang Jinzhou , Liu Li , Zhang Kai , Wang Mingwei , Yin Ping , Luo Kuntian , Deng Min , Kim Wootae , Hou Jing , Shi Yu , Zhu Qian , Chen Lifeng , Hu Sheng , Yue Junqiu , Pi Guoliang , Lou Zhenkun
Published: April 2023

MET regulates STING expression by UPF1
Supplemental Figure 7 from PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
Authors: Pitarresi Jason R. , Norgard Robert J. , Chiarella Anna M. , Suzuki Kensuke , Bakir Basil , Sahu Varun , Li Jinyang , Zhao Jun , Marchand Benoît , Wengyn Maximilian D. , Hsieh Antony , Kim Il-Kyu , Zhang Amy , Sellin Karine , Lee Vivian , Takano Shigetsugu , Miyahara Yoji , Ohtsuka Masayuki , Maitra Anirban , Notta Faiyaz , Kremer Richard , Stanger Ben Z. , Rustgi Anil K.
Published: April 2023

Supplemental Figure 7
Supplemental Figure 4 from PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
Authors: Pitarresi Jason R. , Norgard Robert J. , Chiarella Anna M. , Suzuki Kensuke , Bakir Basil , Sahu Varun , Li Jinyang , Zhao Jun , Marchand Benoît , Wengyn Maximilian D. , Hsieh Antony , Kim Il-Kyu , Zhang Amy , Sellin Karine , Lee Vivian , Takano Shigetsugu , Miyahara Yoji , Ohtsuka Masayuki , Maitra Anirban , Notta Faiyaz , Kremer Richard , Stanger Ben Z. , Rustgi Anil K.
Published: April 2023

Supplemental Figure 4
Supplemental Figure 2 from PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
Authors: Pitarresi Jason R. , Norgard Robert J. , Chiarella Anna M. , Suzuki Kensuke , Bakir Basil , Sahu Varun , Li Jinyang , Zhao Jun , Marchand Benoît , Wengyn Maximilian D. , Hsieh Antony , Kim Il-Kyu , Zhang Amy , Sellin Karine , Lee Vivian , Takano Shigetsugu , Miyahara Yoji , Ohtsuka Masayuki , Maitra Anirban , Notta Faiyaz , Kremer Richard , Stanger Ben Z. , Rustgi Anil K.
Published: April 2023

Supplemental Figure 2
Supplementary Data from Atezolizumab Treatment of Tumors with High Tumor Mutational Burden from MyPathway, a Multicenter, Open-Label, Phase IIa Multiple Basket Study
Authors: Friedman Claire F. , Hainsworth John D. , Kurzrock Razelle , Spigel David R. , Burris Howard A. , Sweeney Christopher J. , Meric-Bernstam Funda , Wang Yong , Levy Jonathan , Grindheim Jessica , Shames David S. , Schulze Katja , Patel Arisha , Swanton Charles
Published: April 2023

Supplementary Data from Atezolizumab Treatment of Tumors with High Tumor Mutational Burden from MyPathway, a Multicenter, Open-Label, Phase IIa Multiple Basket Study
Supplementary Table from Sunvozertinib, a Selective EGFR Inhibitor for Previously Treated Non–Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations
Authors: Wang Mengzhao , Yang James Chih-Hsin , Mitchell Paul L. , Fang Jian , Camidge D. Ross , Nian Weiqi , Chiu Chao-Hua , Zhou Jianying , Zhao Yanqiu , Su Wu-Chou , Yang Tsung-Ying , Zhu Viola W. , Millward Michael , Fan Yun , Huang Wen-Tsung , Cheng Ying , Jiang Liyan , Brungs Daniel , Bazhenova Lyudmila , Lee Chee Khoon , Gao Bo , Xu Yan , Hsu Wei-Hsun , Zheng Li , Jänne Pasi A.
Published: April 2023

Supplementary Table from Sunvozertinib, a Selective EGFR Inhibitor for Previously Treated Non–Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations
Supplementary Data from Adjuvant Pembrolizumab versus IFNα2b or Ipilimumab in Resected High-Risk Melanoma
Authors: Grossmann Kenneth F. , Othus Megan , Patel Sapna P. , Tarhini Ahmad A. , Sondak Vernon K. , Knopp Michael V. , Petrella Teresa M. , Truong Thach-Giao , Khushalani Nikhil I. , Cohen Justine V. , Buchbinder Elizabeth I. , Kendra Kari , Funchain Pauline , Lewis Karl D. , Conry Robert M. , Chmielowski Bartosz , Kudchadkar Ragini R. , Johnson Douglas B. , Li Hongli , Moon James , Eroglu Zeynep , Gastman Brian , Kovacsovics-Bankowski Magdalena , Gunturu Krishna S. , Ebbinghaus Scot W. , Ahsan Sama , Ibrahim Nageatte , Sharon Elad , Korde Larissa A. , Kirkwood John M. , Ribas Antoni
Published: April 2023

Supplementary Data from Adjuvant Pembrolizumab versus IFNα2b or Ipilimumab in Resected High-Risk Melanoma
Supplementary Data from Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1
Authors: Yuan Xiangliang , Duan Yimin , Xiao Yi , Sun Kai , Qi Yutao , Zhang Yuan , Ahmed Zamal , Moiani Davide , Yao Jun , Li Hongzhong , Zhang Lin , Yuzhalin Arseniy E. , Li Ping , Zhang Chenyu , Badu-Nkansah Akosua , Saito Yohei , Liu Xianghua , Kuo Wen-Ling , Ying Haoqiang , Sun Shao-Cong , Chang Jenny C. , Tainer John A. , Yu Dihua
Published: April 2023

Supplementary Data from Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1
Data from Expanding the Reach of Precision Oncology by Drugging All KRAS Mutants
Authors: Hofmann Marco H. , Gerlach Daniel , Misale Sandra , Petronczki Mark , Kraut Norbert
Published: April 2023

Abstract
KRAS is the most frequently mutated oncogene, harboring mutations in approximately one in seven cancers. Allele-specific KRASG12C inhibitors are currently changing the treatment paradigm for patients with KRASG12C-mutated non–small cell lung cancer and colorectal cancer. The success of addressing a previously elusive KRAS allele has fueled drug discovery efforts for all KRAS mutants. Pan-KRAS drugs have the potential to address broad patient populations, including KRASG12D-, KRASG12V-, KRASG13D-, KRASG12R-, and KRASG12A-mutant or KRAS wild-type–amplified cancers, as well as cancers with acquired resistance to KRASG12C inhibitors. Here, we review actively pursued allele-specific and pan-KRAS inhibition strategies and their potential utility.
Significance:
Mutant-selective KRASG12C inhibitors target a fraction (approximately 13.6%) of all KRAS-driven cancers. A broad arsenal of KRAS drugs is needed to comprehensively conquer KRAS-driven cancers. Conceptually, we foresee two future classes of KRAS medicines: mutant-selective KRAS drugs targeting individual variant alleles and pan-KRAS therapeutics targeting a broad range of KRAS alterations.
Supplemental Table 1 from IL4 Limits the Efficacy of Tumor-Targeted Antibody Therapy in a Murine Model
Authors: Surana Rishi , Wang Shangzi , Xu Wei , Jablonski Sandra A. , Weiner Louis M.
Published: April 2023

Gene list used to construct IL-4 focused siRNA library.
Supplemental Figure 2 from IL4 Limits the Efficacy of Tumor-Targeted Antibody Therapy in a Murine Model
Authors: Surana Rishi , Wang Shangzi , Xu Wei , Jablonski Sandra A. , Weiner Louis M.
Published: April 2023

The impact of host-derived IL-4 on expression of soluble mediators in the tumor microenvironment.
Supplementary Data from A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models
Authors: Willingham Stephen B. , Ho Po Y. , Hotson Andrew , Hill Craig , Piccione Emily C. , Hsieh Jessica , Liu Liang , Buggy Joseph J. , McCaffery Ian , Miller Richard A.
Published: April 2023

Supplementary Data
Supplementary Figure 6 from Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL
Authors: Sandoval Gabriel J. , Graham Daniel B. , Gmyrek Grzegorz B. , Akilesh Holly M. , Fujikawa Keiko , Sammut Benedicte , Bhattacharya Deepta , Srivatsan Shuba , Kim Alfred , Shaw Andrey S. , Yang-Iott Katherine , Bassing Craig H. , Duncavage Eric , Xavier Ramnik J. , Swat Wojciech
Published: April 2023

PDF file - 115K, Supplemental Figure 6: Chromosomal translocations visualized by Spectral Karyotyping (SKYTM) analysis of splenic tumors.
Figure S1 from Maelstrom Directs Myeloid-Derived Suppressor Cells to Promote Esophageal Squamous Cell Carcinoma Progression via Activation of the Akt1/RelA/IL8 Signaling Pathway
Authors: Li Pupu , Chen Xinfeng , Qin Guohui , Yue Dongli , Zhang Zhen , Ping Yu , Wang Dan , Zhao Xuan , Song Mengjia , Zhao Qitai , Li Jieyao , Liu Shasha , Wang Dong , Zhang Chaoqi , Lian Jingyao , Cao Ling , Li Feng , Huang Lan , Wang Liping , Yang Li , Huang Jianmin , Li Hong , Zhang Bin , Zhang Yi
Published: April 2023

Overexpression or knockdown of MAEL increased or decreased tumorigenesis in ESCC cells.
Supplementary Figure 4 from Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL
Authors: Sandoval Gabriel J. , Graham Daniel B. , Gmyrek Grzegorz B. , Akilesh Holly M. , Fujikawa Keiko , Sammut Benedicte , Bhattacharya Deepta , Srivatsan Shuba , Kim Alfred , Shaw Andrey S. , Yang-Iott Katherine , Bassing Craig H. , Duncavage Eric , Xavier Ramnik J. , Swat Wojciech
Published: April 2023

PDF file - 61K, Supplemental Figure 4: Diminished expression of endogenous PTEN protein in BCR-Abl transformed Dlg1 deficient B cells.
Supplementary Figure 3 from Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL
Authors: Sandoval Gabriel J. , Graham Daniel B. , Gmyrek Grzegorz B. , Akilesh Holly M. , Fujikawa Keiko , Sammut Benedicte , Bhattacharya Deepta , Srivatsan Shuba , Kim Alfred , Shaw Andrey S. , Yang-Iott Katherine , Bassing Craig H. , Duncavage Eric , Xavier Ramnik J. , Swat Wojciech
Published: April 2023

PDF file - 132K, Supplemental Figure 3: Dissemination of oncogenically- transformed pre-B cells in the in vivo model of retrovirally- induced BCR-ABL-positive B-ALL.