bluuebunny/crossref_metadata_2025 huggingface dataset:
Applications of Spatial Statistics and Spatial Analysis in Flooding Assessment Using GIS: A Case Study in Darab Watershed, Iran
Authors: Shariati Mohsen , Kazemi Mohamad , Samani Reza Naderi , Rad Abdullah Kaviani
Published: March 2022

Floods are amongst the most catastrophic natural disasters, having enormous impacts on both infrastructure and humans. Between 1998 and 2017, this detrimental phenomenon afflicted more than two billion individuals globally. The present investigation utilized two phases of spatial analysis and spatial statistics from ArcGIS in order to precisely assess the hazard of flooding in the Darab watershed, Iran. Following a survey of literature and case studies, seven criteria for flood risk were recognized to be effective: dem, slope, drainage density, NDVI, land cover, geology, and rainfall. The initial phase was operated using fuzzy logic and AHP in order to overlap layers. In order to prepare of flood hazard mapping, kernel density and zonal statistics were used to compute flood hazard density and flood hazard zoning. In flood hazard zones, spatial statistics in ArcGIS Pro were applied to detect high-and low-risk clusters. An innovation in this study is the use of local data to detect high-risk and low-risk flood clusters. According to the findings, the Gamma operator (0.9) was recognized as the optimal operator for flooding zoning, and only 7344/63432 hectares of the study area had a high risk of flooding, with only two high-risk flooding clusters in the Darab watershed. The boundary was near the heights in the north and northeast of the study, which corresponded to townships with a population of less than 5,000 people. Overall, the findings of this study demonstrated that clusters and outliers' analysis, as well as hotspot analysis, are effective complementary techniques to recognize high- and low-risk flood clusters. Combining spatial analysis with spatial statistics may be a reliable and efficient approach for natural scientific investigations.
Morphological and molecular comparison of three centric diatoms (Bacillariophyceae: Chaetoceros) isolated from the coast of Eastern Thailand
Authors: Hiransuchalert Rachanimuk , Kutako Maliwan , Watchasit Sarayut , Kaewduang Mookthida , Setthamongkol Pakawan , Chindudsadeegul Parinya , Gunbua Vichaya , Jaritkhuan Somtawin
Published: March 2022

The objective of this study was to identify Chaetoceros species using microscopic observations, sequence analysis of 18S rDNA, random amplified polymorphic DNA (RAPD) barcoding and nuclear magnetic resonance (NMR) spectroscopy. Chaetoceros were obtained from three different algae laboratories: Center of Excellence for Marine Biotechnology (CEMB), Chanthaburi Coastal Fisheries Research and Development (CHAN) and Institute of Marine Science, Burapha University (BIM). Genomic DNA for the RAPD analysis was extracted using the phenol-chloroform method, followed by 18S rDNA amplification. The 18S rDNA sequence analysis showed that Chaetoceros CEMB was most similar to C. gracilis (e-value = 0.0, identity = 98%), Chaetoceros CHAN was most similar to C. debilis (e-value = 0.0, identity = 99%) and Chaetoceros BIM was most similar to C. debilis (e-value = 0.0, identity = 98%). The RAPD results revealed differences in the three Chaetoceros isolates with polymorphisms between 30.43% and 60.00%, and Chaetoceros CEMB showed high polymorphic bands. Scanning electron microscopy revealed that Chaetoceros CEMB were larger and had larger setae compared with the other isolates (P < 0.05). The results of the NMR characterization of metabolites were consistent with the results of the sequence and morphological analyses. The concentrations of several metabolites, including chlorophyll c1, chlorophyll a, myo-inositol, fucoxanthin, astaxanthin, lutein and zeaxanthin, were lower in Chaetoceros CEMB than in Chaetoceros BIM and CHAN. However, high concentrations of fatty acids, such as oleic acid, linoleic acid, α-linolenic acid and arachidic acid, were observed in all isolates. Generally, the results of this study will aid future studies examining the diversity of Chaetoceros in various culture environments.
Effect of Land Preparation, Water Management Practices and Planting Operation on Planting Quality in Rice Production
Authors: MAIRGHANY MODATHER , Adam Nor Maria , Elsoragaby Suha
Published: March 2022

Water irrigation management, drainage, with land preparation in paddy field has crucial effects on rice planting quality and rice production. This study investigated the effects of water and land management on the performance of mechanical transplanting machines and the quality of planting. The investigation included the effect of land preparation before planting, soil condition during planting, and water management. Long field flooding periods combined with short sedimentation periods reduce the soil penetration resistance and soil bulk density which affect negatively the mechanical transplanting performance causing planting losses. The result showed the soil's physical properties penetration resistance and bulk density have a negative relation to planting losses. When the sedimentation period increased, the soil penetration resistance increased. There were strong relationships between the flooding period, sedimentation period, field water depth, and soil physical properties with transplanting speed, planting density, planting spacing, planting losses, and the depth of planting. About 50.5% of the farmers used the right required amount of water irrigation, and also the right time for irrigation.
Novel pyroptosis-associated genes signature for predicting the prognosis of Sarcoma
Authors: Wen Hao , Guo Dandan , Zhao Zhenguo , Xin Xin , Cao Jiachen , Chen ChengXin , Shi Qi , Li Ya , Li Yujun , Jiang Yuliang , Liu Chunxia , Li Feng
Published: March 2022

Background
Sarcoma is a rare mesenchymal malignant tumor. Recently, pyroptosis has been reported to be a mode of programmed cell death. Nonetheless, levels of pyroptosis-associated genes in sarcoma and its relevance to prognostic outcomes are yet to be elucidated.
Results
We established 33 pyroptosis regulatory genes in sarcoma. Sarcoma cases were classified into two subtypes with regards to differentially expressed genes (DEGs). We constructed a polygenic profile using The Cancer Genome Atlas (TCGA) cohort to assess the prognostic significance of pyroptosis-associated genes for survival. We established a profile composed of 7 genes and classified the sarcoma patients into low- and high-risk groups throughleast absolute shrinkage and selection operator (LASSO) Cox regression. Survival rate of low-risk sarcoma patients was markedly higher, relative to high-risk group (P < 0.001). In combination with clinical features, the risk score was established to be an independent predictive factor for OS of sarcoma patients. Chemotherapeutic Drug Sensitivity response analysis found 65 drugs with higher drug sensitivity in low-risk, than in high-risk group and 14 drugs with higher drug sensitivity in the high-risk patient group, compared to low-risk patient group. Consequently, Gene ontology (GO), Kyoto Encylopedia of Genes and Genomes (KEGG), immune responses and mutations analyses were used to investigate the reasons for the result, which indicated that immune cells infiltration, especially T cell infiltration, and mutations in certain genes, such as TP53 and RB1, may be responsible for poor survival in high-risk patient group.
Conclusions
our research suggest that pyroptosis is closely associated with Sarcoma, and these findings confirm that pyroptosis-associated seven genes (IGHG2, PODXL2, LRRC17, GABRA3, SCUBE3, HLF, RFLNB) have a critical role in sarcoma and are potential prognostic factors for sarcoma.
Altered perception of emotional faces in lonely adults
Authors: Akram Umair , Stevenson Jodie
Published: March 2022

The evidence based concerning the relationship between loneliness and the perception of facial cues of emotion remains mixed. This study further examined the categorisation accuracy, and perceived emotional intensity and emotional valence of facial expressions of emotion in adults displaying high, medium, and low levels of loneliness, whilst controlling for symptoms of insomnia anxiety and depression. Using the University of California Loneliness Scale, participants were stratified into those experiencing high (N=83), medium (N=97), and low levels (N=93) of loneliness. Observing facial expressions of emotion from the Karolinska Directed Emotional Faces database, participants were assessed on their categorisation accuracy and ratings of emotional intensity and valence. Greater levels of loneliness were associated with positively valanced ratings of angry faces; negatively valanced ratings of facially expressed sadness and happiness; and difficulties in identifying happy faces after controlling for comorbid psychiatric symptoms. The outcomes present psychosocial implications for individuals experiencing loneliness.
A watershed water quality prediction model based on attention mechanism and Bi-LSTM
Authors: Zhang Qiang , Wang Ruiqi , Qi Ying , Wen Fei
Published: March 2022

Accurate prediction of water quality is conducive to intelligent management and control of watershed ecology. Water quality data has time series characteristics, and although methods such as LSTM can capture sequence correlations in time series data, these methods do not consider the impact of bidirectional neighborhoods on the model, and they are not able to pay attention to the feature sequences to varying degrees. Aiming at this problem, this paper proposes a watershed water quality prediction model based on attention mechanism and bidirectional LSTM neural network (AT-BILSTM). The model mainly contains the Bi-LSTM layer and the temporal attention layer, and the attention mechanism is introduced after the bidirectional feature extraction of the water quality time series data to highlight the data series that have a key impact on the prediction results, and effectively use the sequence correlation of the watershed water quality data to improve the accuracy of the model. Finally, the actual datasets of four monitoring sites in the Lanzhou section of the Yellow River Basin in China were used to verify the effectiveness of the method. After comparing the reference model, the results show that the proposed model combines the bidirectional nonlinear mapping ability of Bi-LSTM and the feature-weighted characteristics of the attention mechanism. Taking FuHe Bridge as an example, compared with the original LSTM model, the RMSE and MAE of the model are reduced to 0.101 and 0.059, respectively, and the R2 is increased to 0.970, which has the best prediction performance in four sections, which can provide decision-making basis for comprehensive water quality management and pollutant control in the river basin.
Phylogeography and population genetics of a headwater-stream adapted crayfish, Cambarus pristinus (Decapoda: Cambaridae), from the Cumberland Plateau in Tennessee
Authors: Grubb Brooke A , Johansen John W. , Blanton Rebecca E.
Published: March 2022

Assessments of genetic diversity for imperiled species can provide a baseline for determining the relative impacts of contemporary anthropogenic threats (e.g., habitat fragmentation) on population connectivity and identifying historical factors contributing to population structure. We conducted a population genetics and phylogeographic assessment of the imperiled Pristine Crayfish (Cambarus pristinus) sampled throughout its range encompassing two morphologically distinct forms. Pristine Crayfish exhibit a disjunct distribution throughout lower order tributaries suggesting they are headwater-adapted species. The two morphologically distinct forms of the Pristine Crayfish are found in the upper Caney Fork (nominal Caney Fork form) and the Big Brush Creek and Cane Creek systems (Sequatchie form). We used 19 microsatellite loci and the cytochrome oxidase subunit I (COI) gene to assess population connectivity and genetic diversity of the Pristine Crayfish. Haplotypes recovered from the COI gene revealed that historic connectivity was maintained within each form of the Pristine Crayfish. However, the divergence between forms was high (2.3%), suggesting each form is on an independent evolutionary trajectory, which supports recognition of the Sequatchie form as a distinct taxon. Microsatellite analyses for the Caney Fork form recovered a high degree of population isolation and support for six genetically isolated population. In addition, genetic diversity metrics per population and for the Caney Fork form were low suggesting that the Caney Fork form is at an increased risk of extinction under anthropogenic disturbances. We suggest that each form receive continued listing protection and conservation resources and that the Sequatchie form be treated as a unique taxon.
A novel design method for TPMS lattice structures with complex contour based on moving elements method
Authors: Ma Xiangyu , Zhang David Zhengwen , Yu Xuewei , Ren Zhihao , Mao Shenglan
Published: March 2022

Over the past few decades, there have been many important achievements on the design, research and development of minimal surface lattice structures. In this work, we propose a modeling method for triply periodic minimal surfaces (TPMS) lattice structures with complex contours. This method is based on moving elements method (MEM) and mainly includes the following parts, such as dividing the model mesh, solving the iso-surface of the TPMS in the model, obtaining the TPMS lattice structure triangular surface of the model outline, integrating the interior of the model and the outline, and finally generating an STL file that can be used for additive manufacturing. Furthermore, the representative femur model, rabbit model and gear model are provided as case studies to verify the validity and correctness of the proposed modeling method. Then, this approach is compared with the distance field method in terms of modeling speed and modeling accuracy. The research results show that the modeling method proposed in this paper has certain advantages in the generation of complex model lattice structures. Moreover, this method provides technical means and simulation data for designing TPMS lattice structures with complex contour, and offers the underlying design ideas for the development and application of the excellent physical properties of TPMS lattice structures in medicine and engineering.
Catalyzing Success in Community-based Conservation
Authors: Fariss Brandie , DeMello Nicole , Powlen Kathryn A. , Latimer Christopher E. , Masuda Yuta , Kennedy Christina M.
Published: March 2022

Efforts to devolve rights and engage Indigenous Peoples and local communities in conservation have increased the demand for evidence of the efficacy of community-based conservation (CBC) and insights into what enables its success. We curated a diverse sample of 128 projects reporting both human well-being and environmental outcomes and coded 57 national-level, community-level, project-level, and control variables. We found that over 80% of CBC projects had some positive human well-being or environmental outcomes, but only 32% achieved positive outcomes for both. Applying random forest classification, we found that the best predictors of combined success could be distilled to 17 variables representative of various policy levers and actionable opportunities for conservation practitioners related to national contexts, community characteristics, and the implementation of various strategies and interventions informed by existing CBC frameworks. We found that CBC projects had higher probabilities of combined success when they occurred in national contexts supportive of effective local governance, partnered with communities inclined toward collective action, acknowledged conflict or trust issues that could undermine it, promoted economic diversification, and invested in various capacity-building interventions, providing important insights into how to encourage greater success in CBC.
BertSRC: BERT-based Semantic Relation Classification
Authors: Lee Yeawon , Son Jinseok , Song Min
Published: March 2022

The relationship between biomedical entities is complex, and many relationships have not yet been identified. By applying semantic relation classification techniques to the accumulated biomedical literature, existing relationships between biomedical entities that can help to infer previously unknown relationships are efficiently grasped. To develop semantic relation classification models, constructing a training dataset that is manually annotated by biomedical experts with semantic relationships among biomedical entities, such as genes, diseases, and compounds, is essential. In this paper, we aim to build such a dataset. To validate the usability of the training dataset and to improve the performance of the relation extraction task, we built a relation classification model based on bidirectional encoder representations from transformers (BERT) trained on our dataset, applying our newly proposed fine-tuning methodology. In experiments comparing performance among several models based on different deep learning algorithms, our model with the proposed fine-tuning methodology showed the best performance. The experimental results show that the constructed training dataset is an important information resource for the development and evaluation of semantic relationship extraction models. Furthermore, relationship extraction performance can be improved by integrating our proposed fine-tuning methodology into semantic relation algorithms. Therefore, this can lead to the promotion of future text mining research in the biomedical field.
Analysis in the Influence Factors of Urethroplasty in DSD
Authors: Yu Jing , Zhang Weiping , Sun Ning , Song Hongcheng , Li Minglei , Gong Chunxiu , Li Lele
Published: March 2022

Objective To explore the risk factors of urethroplasty among patients with Disorder of Sex Development (DSD).Method We reviewed patients with DSD who underwent urethroplasty from January 2016 to December 2019 retrospectively. Patients were divided into four groups: the successful group, the urethrocutaneous fistula group, the urethral diverticulum group, and the urethral stricture group. Risk factors were determined from the following data included the DSD classification, the age of first operation, length of urethral defect, degree of hypospadias, cryptorchidism, micropenis, gonad type, hormone therapy before operation, transposition of penis and scrotum, surgical strategy, urethral covering material, and postoperative catheter removal time. We explored the difference of each factor between four groups through the comparative study of single factor and multifactor logistic regression analysis of related factors.Result 122 cases were enrolled in this group (n = 122), 12 cases were lost to follow-up. Median follow-up was 28months(12 months - 55 months）.We found the success rate of operation decreased with longer urethral defect (B=-0.473, P=0.005). The success rate of operation was higher in staged operation and TPIT-related operation than primary operation (B=1.238, P=0.006）and TPIT-nonrelated operation (B=2.293, P=0.001) . Although there was a significant difference between the age of the first operation and the occurrence of urethrocutaneous fistula (P=0.006<0.05), there was no significant difference in logistic regression analysis（P=0.161 > 0.05）. The incidence of urethrocutaneous fistula was lower in TPIT-related operation than in TPIT-nonrelated operation(B=-2.507, P=0.000) . The incidence of postoperative urethral diverticulum was lower in staged operation than in primary operation (B=-1.737 P=0.015). Conclusion For patients with Disorder of Sex Development undergoing urethroplasty, the length of urethral defect is an independent risk factor affecting both the success rate of operation and the urethrocutaneous fistula. The age of the first operation has a statistically significant effect on the occurrence of postoperative urethrocutaneous fistula, but it is not an independent factor. Urethrocutaneous fistula is less found in TPIT-related operation in the study. Staged operation is an independent protective factor for postoperative urethral diverticulum compared with one-stage operation but isn’t related to urethrocutaneous fistula.
The Relationship Between the Effectiveness of Heparin Administration and Hypercoagulation Complications in Hospitalized Patients With Confirmed COVID-19
Authors: Fachri Muhammad , Hatta Mochammad , Tarigan Sefia Nabila Nur Azmi , Akapura Risky , Dwiyanti Ressy , Syukri Ahmad , Junita Ade Rifka , Febrianty Andini
Published: March 2022

Background: Thrombotic complications of COVID-19 are a worrisome aspect of the disease due to its high incidence in critically ill patients and poor clinical manifestations. The aim of this study was to determine the relationship between the effectiveness of heparin administration and complications of hypercoagulation in hospitalized patients with confirmed COVID-19.Method: This research was analytically observational. The study design used was a retrospective cohort approach of pre- and post-tests. This study used secondary data taken from medical records of inpatients with confirmed COVID-19 at Islamic Hospital Jakarta Sukapura. The total sampling technique was used. Result: There were 98 study subjects, with 35 patients receiving UFH and 63 patients receiving LMWH (fondaparinux). Most of the subjects were women (52%), with the most common age group being >60 years (30.6%). In the UFH group, the greatest decrease (0.01±0.5 g FEU/mL) was observed in 12 patients (34.3%). In the LMWH group (fondaparinux), the greatest decrease (0.01±0.5 g FEU/mL) was observed in 15 patients (23.8%). Additionally, there was no significant difference between UFH and fondaparinux (p 0.193) in hospitalized patients with confirmed COVID-19 for the period of August 2020 – August 2021. Most inpatients with confirmed COVID-19 at RSIJ Sukapura were aged 50-59 years and were women. Conclusion: There was a tendency toward increased D-dimer values, normal PT values, normal APTT values, and increased fibrinogen values in each COVID-19 patient, but there was no statistically significant relationship. There was also no significant relationship between the D-dimer and APTT parameters, whereas the PT parameter showed a significant relationship in confirmed COVID-19 inpatients.
Effect of Positive end-Expiratory Pressure on Pulmonary Compliance and Pulmonary Complications in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy
Authors: NI LIFENG , Chen Menglan , Huang Ling’er , Wang Kuirong , Zhou Yanfeng
Published: March 2022

Purpose
To observe the effects of different levels of positive end-expiratory pressure (PEEP) ventilation strategies on pulmonary compliance and complications in patients undergoing robotic-assisted laparoscopic prostate surgery.
Methods
A total of 120 patients with American Society of Anesthesiologists Physical Status Class I or II who underwent elective robotic-assisted laparoscopic prostatectomy were enrolled. The patients were randomly divided into three groups of 40 patients each: control (PEEP = 0 cmH2O), low-level (PEEP = 5 cmH2O), and high-level (PEEP = 10 cmH2O). Volume control ventilation with an intraoperative deep muscle relaxation strategy was used intraoperatively. Respiratory mechanics indexes were recorded at six time points: 10 min after anesthesia induction, immediately after pneumoperitoneum establishment, 30 min, 1 h, 1.5 h, and at the end of pneumoperitoneum (T1-T6). Arterial blood gas analysis and oxygenation index calculation were performed at T1, T4, and after tracheal extubation (T7). Postoperative pulmonary complications were also recorded.
Results
After pneumoperitoneum, peak inspiratory pressure (Ppeak), plateau pressure (Pplat), mean pressure (Pmean), driving pressure (ΔP), and airway resistance (Raw) increased significantly and pulmonary compliance (Crs) decreased, persisting during pneumoperitoneum in all groups. Between T2–T5, the low-level group had the highest Crs value and the lowestΔP (driving pressure) value relative to the high-level and control groups (P < 0.05). At T4 and T7, the PaCO2 and PaO2/FiO2 did not significantly differ among the three groups. There was no significant difference in postoperative pulmonary complications among the three groups.
Conclusion
High levels of intraoperative PEEP increased lung compliance without significantly reducing postoperative pulmonary complications.
Downregulated FPR2 expression in the epileptogenic foci of focal cortical dysplasia type IIb and tuberous sclerosis complex patients
Authors: Liu Shiyong , Huang Kaixuan , Wang Zhongke , He Zeng , Li Yang , Li Shujing , Shen Kaifeng , Zhu Gang , Liu Zhonghong , Lv Shengqing , Zhang Chunqing , Yang Hui , Yang Xiaolin
Published: March 2022

Focal cortical dysplasia IIb (FCDIIb) and tuberous sclerosis complex (TSC) are classic pathological forms of refractory epilepsy. Increasing evidence has shown that inflammation resolution plays an important role in epilepsy. G-protein coupled formyl peptide receptor 2 (FPR2) resolves inflammation and promotes neurodevelopment by binding with resolvin D1 (RvD1), which indicates that FPR2 may be involved in epilepsy associated with FCDIIb and TSC. In this study, the expression of FPR2 and RvD1 was decreased in the epileptogenic focus and was negatively correlated with seizure frequency in FCDIIb and TSC patients. FPR2 was more widely distributed in neurons and microglia than astrocytes. Moreover, the expression levels of the RvD1 synthases 5-lipoxygenase (5-LOX) and 15-LOX were decreased in the context of FCDIIb and TSC. Activation of the NF-κB pathway in an vitro epilepsy model was inhibited by FPR2 activation using RvD1, but the FPR2 antagonist WRW4 exerted the opposite effect. Taken together, our results showed that the decreases in RvD1 and FPR2 were involved in FCDIIb and TSC with epilepsy and that FPR2 activation mediated by RvD1 contributed to inhibiting the inflammatory signaling pathway, suggesting that FPR2 activation may have a potential antiepileptic effect by restricting neuroinflammation in FCDIIb and TSC.
Different concentrations of albumin versus crystalloid in patients with severe sepsis and septic shock: a meta-analysis of randomized clinical trials
Authors: Geng Li , Tian Xiaoxue , Gao Zifeng , Mao Aiqin , He Chao , Feng Lei
Published: March 2022

Background
The best type of resuscitation fluids for severe sepsis and septic shock patients remains unclear. The aim of this study was to evalute the effacy of different concentrations of albumin on reducing the mortality rate of theses patients by meta-analysis.
Methods
PubMed, EMBASE and Web of Science databases were used for screening the relevant studies. Ramdonized controlled trials (RCTs) were eligible if they compared the effects of albumin with crystalloid on mortality in severe sepsis and septic shock patients. Data were examined and extracted by two reviewers independently. Any disagreements were resolved by consensus with or without the help from a third reviewer. Data including mortality, sample size of the patients and resuscitation endpoints were extracted. Meta-analysis was carried out using STATA version 16.0, based on the corresponding odds ratios with 95% confidence intervals.
Results
Eight studies with a total of 5124 severe sepsis patients and 3482 septic shock patients were included in this study. Compared with crystalloid, the use of albumin slightly reduced the 90-day mortality of severe sepsis patients [OR 0.91 (0.80, 1.02); P = 0.11] and significantly improved the outcome of septic shock patients [OR 0.85 (0.74, 0.99); P = 0.04]. Further analysis showed a potentially benenifical role of both 4–5% and 20% albumin on reducing the mortality of severe sepsis patients. The use of 20% albumin significantly decreased the 90-day mortality of septic shock patients [OR 0.81 (0.67, 0.98); P = 0.03], which was better than 4–5% albumin and crystalloid.
Conclusions
Albumin treatment, particularly 20% albumin, significantly reduced the 90-day mortality in septic shock patients. Either 4–5% or 20% of albumin may work better than crystalloid in improving the survival rate of patients with severe sepsis, but more relative RCTs are required for validation.
Short and Long-term Consequences/results of Covered Stents in Children for the Management of Complex Coarctation of the Aorta
Authors: Mortezayian Hojat , Ghaemi Hamidreza , Moradian Maryam , Khalili Yasaman , Haas Nikolaus A , Rahimzadeh Fereshteh
Published: March 2022

Background: The use of covered stents in cases of complex coarctation of the Aorta is now increasing. However, its long-term benefits for children, adolescents and young adults remain unclear. We assessed the long-term results of covered stents in children with complex coarctation of the Aorta. Methods: Forty-seven children with complex coarctation of the Aorta treated with covered stents were retrospectively assessed. The patients were followed up for 6 to 12 months to evaluate the long-term outcome. Results: The most common indications for using covered stent were long segment coarctation of the Aorta plus hypoplasia of the aortic arch (23.4%) followed by coarctation of the Aorta with PDA (23.4%) and interrupted aortic arch (19.1%). A single stent was used in 87.2%, two and three covered stents were used in 10.6% and 2.1%, respectively. During follow-up, short-term procedural complications were detected in 25.5% included isolated residual coarctation of the Aorta in 25.0%, followed by residual coarctation of the Aorta plus closure of the left subclavian artery in 16.6%. Short-term complications were femoral artery dissection (8.3%), femoral artery thrombosis (8.3%), stent dislocation and closure of left subclavian artery (8.3%), residual COA and closure of left subclavian artery (16.6%), residual COA (25%), endoleak (8.3%), endoleak and pseudoaneurysm (8.3%), endoteliaztion (8.3%) and retroperitoneal hematoma (8.3%). In long-term following-up, 10.6% showed significant complications including endoleak, residual hypertension, and residual coarctation. Overall, 25.6% underwent re-dilation successfully. Conclusion: The covered stent can be used as an effective and uncomplicated treatment in children with complex coarctation of the Aorta.
Beta Zone Parapapillary Atrophy in Elderly Chinese
Authors: Zhou Ling Xiao , Shao Lei , Zhou Wen Da , Xu Liang , Li Rong , Wei Wen Bin
Published: March 2022

Purpose: Assess the beta zone parapapillary atrophy in elderly Chinese.Patients and methods: The Beijing Eye Study 2011 is a population-based cross-sectional study，which includes 3468 patients with the average age of 64.5±9.8 years. The beta zone of parapapillary atrophy was captured and analyzed morphometrically by using colour optic disc photographs.Results: The beta zone was found in 1358 (39.9%) eyes, measuring 0.37± 0.84mm2 in size, 203.5±81.8° in circumferential angle, 0.36±0.27mm in the maximum radial extent, the most often and longest in the temporal peripapillary region, followed by the temporal inferior region and the temporal superior region, the nasal region at least. Beta zone has statistically significant association with male gender (P=0.001), myopic refractive error (P=0.003), thinner retinal nerve fiber layer thickness (P＜0.001), thinner subfoveal choroidal thickness (P＜0.001), bigger size of optic disc size (P＜0.001). The size of beta zone has statistically significant association with longer axial length (P=0.004)，increasing age (P＜0.001), urban (P=0.025), cardiovascular disease history (P=0.025), without age related macular degeneration (P=0.038), myopic ametropia (P＜0.001), thinner retinal nerve fiber layer thickness (P=0.001), thinner subfoveal choroidal thickness (P＜0.001), bigger size of optic disc size (P=0.001).Conclusion: The population prevalence of beta zone was 39.9% in elderly Chinese. The area of the beta zone has statistically significant association with age, urban, the thickness of retinal nerve fiber layer, age related macular degeneration, cardiovascular disease history, axial length, myopic refractive error, size of optic disc size, the thickness of subfoveal choroidal.
Soil compaction drives an intra-genotype Leaf Economics Spectrum in wine grapes
Authors: Martin Adam , Mariani Rachel , Cathline Kimberley A. , Duncan Michael , Paroshy Nicholas J. , Robertson Gavin
Published: March 2022

Purpose Intraspecific trait variation is a critical determinant of ecosystem processes, especially in agroecosystems where single species or genotypes exist in very high abundances. Yet to date only a small number of studies have evaluated if, how, or why traits forming the Leaf Economics Spectrum (LES) vary within crops, despite such studies informing our understanding of: 1) the environmental factors that drive crop LES trait variation; and 2) how domestication has altered LES traits in crops vs. wild plants.Methods We assess intragenotype variation in LES traits in ‘Chardonnay’ (Vitis vinifera)—among the world’s most commercially important crops, across a soil compaction gradient: one of the most prominent characteristics of agricultural soils that may drive crop trait variation.Results ‘Chardonnay’ traits covary along an intragenotype LES in patterns that were qualitatively similar to those observed among wild plants: resource acquiring vines expressed a combination of high mass-based photosynthesis (Amass), mass-based dark respiration (Rmass), leaf nitrogen concentrations (N), coupled with low leaf mass per area (LMA); the opposite set of trait values defined the resource conserving end of the ‘Chardonnay’ LES. Traits related to resource acquisition (Amass, Rmass, and leaf N) declined with greater bulk density, while traits related to investment in leaf construction costs (LMA) increased with greater bulk density.Conclusion Our findings uncover a deeper understanding of both the domestication syndromes in grapevines, and expand our understanding of trait-based crop responses to environmental change and gradients.
DLBCL with an associated IgM serum paraprotein (IgMs- DLBCL) has poor prognosis and frequent mutations in MYD88, CD79B and TP53 genes
Authors: Cox Maria Christina , Marcheselli Luigi , Scafetta Giorgia , Visco Carlo , Hohaus Stefan , Annibali Ombretta , Musuraca Gerardo , Fabbri Alberto , Cantonetti Maria , Pelliccia Sabrina , Papotti Robel , Petrucci Luigi , Tani Monica , Battistini Roberta , Arcari Annalisa , Luminari Stefano , Lopez Gianluca , Alma Eleonora , Pupo Livio , Carli Giuseppe , Marchesi Francesco , Re Francesca , Scarpino Stefania , D’amore Emanuele , Larocca Luigi M , Bianchi Antonella , Pepe Giuseppina , Natalino Fiammetta , Anticoli-Borza Paola , Cenfra Natalia , Andriani Alessandro , Abruzzese Elisabetta , Tesei Cristiano , Leoncini Lorenzo , Asioli Silvia , Ruco Luigi , Napoli Arianna Di
Published: March 2022

PURPOUSE: to assess the clinicopathologic features of a poorly defined subset of diffuse large b-cell lymphoma, which is characterized by the secretion of an IgM paraprotein (IgMs-DLBCL). EXPERIMENTAL DESIGN: multicentre, retrospective, and comparative study to analyse with an integrated diagnostic approach the IgMs-DLBCL subset.RESULTS: Overall, 650 DLBCL were enrolled: 102 had an associated serum IgM and 56 other paraproteins (OP), the remaining 492 cases were the reference group (REF). IgMs-DLBCL were characterized by older age, advanced stage, dissemination to extra-nodal organs, elevated LDH and poor PS. As a result, the majority of IgMs had a high IPI, NCC-IPI and CNS-IPI score (p<.001).Furthermore, IgMs qualified as an independent prognostic factor in multivariate analysis for both PFS and OS (p<.001). Remarkably, the incidence of CNS involvement was higher in the IgMs compared to the OP and the REF subsets, respectively (p<.001). IgMs-DLBCL were characterized by: 1) prevalence of non-GCB/ABC-type; 2) frequent overexpression of BCL-2; 3) preferential IGVH4-34 gene usage; 4) MYD88 and TP53 mutations, both occurringin 30.8% of IgMs cases (95%CI, 14.3-51.8) CONCLUSION: Our study was carried out on the largest series of IgMs-DLBCL reported so far. This is a sizeable subset of DLBCL (7.9%, 95%CI, 5.9-10.5%),which is worth to detect at diagnosis. Remarkably, IgMs-DLBCL harbours features of a molecular subset that associate with a worse outcome. Indeed, more studies are necessary to fully understand the molecular pathogenesis of IgMs-DLBCL and the biological mechanisms leading to the high rate of CNS spreading.
Molecular docking of substituted pyrazolone analogs targeting MAO-B as therapeutic site for Parkinson: an in-silico study
Authors: Ashtekar Harsha , Aggarwal Natasha , Fernandes Zeena , Rao Apoorva , Varghese Nimmy
Published: March 2022

Parkinson’s disease is considered as common age-related progressive neuronal disorder characterized by motor, sensory, and cognitive dysfunction. Current medication for PD offers only symptomatic relief but no cure. Although it is considered that these medicines can produce acute or chronic side effects, and becomes less effective over a time. Owing to this concerns, the discovery of novel molecule is of considerable interest. Depletion of dopamine is one of the major cause of PD which is regulated by Monoamines. In this regards monoamine oxidase (MAO-B) inhibitors are of great interest to combat PD. Among several known molecules Pyrazolone has been evident for the MAO-B inhibitory potential. Therefore, in the present study MAO-B is selected as a key target to examine the interaction of Pyrazolone derivatives with crystal structure of MAO-B. For this purpose, Molecular docking, Quick prop module, and Mechanics/generalized born surface area (MM-GBSA) parameters are analyzed, to evaluate Molecular interaction, Pharmacokinetic parameters, and Binding energy. Further results show that compounds attached with chloride and nitrogen group have better binding efficiency, therefore they can be selected as a promising drug candidate for the treatment of PD.
Auditory dominance in processing Chinese syntactic abnormalities in response to competing audio-visual stimuli
Authors: Pei changfu , Huang Xunan , Li Yuqin , Chen Baodan , Lu Bin , Peng Yueheng , Si Yajing , Zhang Xiabing , Zhang Tao , Yao Dezhong , Li Fali , Xu Peng
Published: March 2022

Language is a remarkable cognitive ability that can be expressed through visuospatial (written language) or audio-oral (spoken language) modalities. When visual characters and auditory speech exhibit conflicting features, individuals may selectively attend to a certain feature. However, the dominant modality in such a situation and the neural mechanism underlying it are both still unclear. To investigate the neural mechanism underlying audio-visual competition in Chinese, newly developed Chinese character-speech materials were presented to the study participants, and the participants' electroencephalographic (EEG) and behavioural responses were recorded. When audio-visual competition occurs, the brain more accurately recognizes meaningless speech sounds. Event-related potential (ERP) analysis showed that incongruent audio-visual stimuli induced a larger N400 amplitude than congruent audio-visual stimuli elicited. In addition, the N400 amplitude was larger in the auditory mismatch condition than in the visual mismatch condition. In terms of the brain network, compared with that in the visual mismatch condition, the dominant reconfiguration pattern in the auditory mismatch condition was the stronger linkages in the posterior occipital-parietal areas. Our research illustrates the superiority of the auditory modality over the visual modality, extending our understanding of the neural mechanisms of audio-visual competition in Chinese.
Factors Affecting the Choice of Cashless Payment in Vietnam
Authors: HO Chi H.P. , Nguyen Kiet Tuan , QUACH Tu D.
Published: March 2022

To study the factors affecting the choice of cashless payments, in cases where customers have a choice between cash and cashless payment, the article used data collected from surveys of 405 individuals residing in two big cities of Vietnam. The paper applied conditional logistic regression to point out the characteristics that affect the non-cash payment decision. The results show that women are more likely to use the service than men and peaking at the age of 36–40. Moreover, income level, occupation, and trust are found to have a significant association with the choice of cashless payment, thereby drawing some practical implications.
In silico identification of vaccine and drug targets for Corynebacterium ulcerans and the recently described C. silvaticum
Authors: Cerqueira Janaína Canário , Viana Marcus Vinicius Canário , Jaiswal Arun Kumar , Soares Siomar Castro , Tiwari Sandeep , Wattam Alice Rebecca , Silva Artur , Alzahrani Khalid J. , Tambuwala Murtaza M. , Barh Debmalya , Azevedo Vasco Ariston Carvalho
Published: March 2022

The availability of complete genomes of pathogens enables in silico analyzes that can be used to develop new control methods, reducing the time, cost, and necessity of pathogen cultivation. In this study, we developed a novel pipeline for the prediction of common broad-spectrum drug and vaccine candidates against the diphtheria toxin producing Corynebacterium ulcerans and the recently described C. silvaticum species, considered as a zoonotic potential. We found four common, non-host homologous, virulent, essential cytoplasmic druggable proteins that belong to metabolic pathways and are involved in the regulation in other essential genes. In addition, the docking analysis showed natural compounds from the ZINC database as drug candidate against the target proteins. We also identified nine vaccine candidates involved in transport and regulation of permeability of substances important to the cell. We hypothesize that these identified therapeutic targets and antimicrobial drugs could be considered for prophylaxis and hence, should be subjected to further experimental validations. We suggest that the pipeline can be used on any pathogen.
Visual Analysis of Uterine Adhesion Research Based on citespace: Bibliometric Analysis from 2006 to 2021
Authors: Ding Dou-Dou , Zuo Man-Zhen , Zhou Quan , He Ze-Xian
Published: March 2022

Background
Intrauterine adhesionis caused by a variety of reasons, such as damage of the endometrial basal layer, adhesion or occlusion of the uterine cavity or cervix in different degrees.Seriously endangering women's physical and mental health.
Objective
The purpose of this paper is to analyze the research development of intrauterine adhesions in recent 15 years, explore the future development direction, and promote the development of this field.
Methods
With intrauterine adhesions and Ashman's syndrome as the theme, the related literatures from January 2006 to July 2021 in the Web of Science were searched, and the visual atlas was analyzed by CiteSpace software.
Results
A total of 644 literatures were included. The key words related to intrauterine adhesion mainly include adhesion, pregnancy, expression, intrauterine adhesions, women, adhesion molecule, diagnosis, activation, hysteroscopy and fertility,etc.Six clusters were obtained by keywords analysis, involving hysteroscopy, placenta, office hysteroscopy, uterus and laparoscopy. Co-occurrence of keywords shows that the research focus in recent years is on endometrial repair and regeneration.
Conclusions
Through the bibliometric analysis of WOS research on intrauterine adhesions in recent 15 years, the comprehensive analysis of countries, institutions, authors and keywords is obtained, which has a clear guiding significance for guiding the future development of intrauterine adhesions.
Long COVID and Symptom Trajectory in a Representative Sample of Americans
Authors: Wu Qiao , Ailshire Jennifer , Crimmins Eileen
Published: March 2022

People who have COVID-19 can experience symptoms for months. Studies on long COVID in the population lack representative samples and longitudinal data focusing on new-onset symptoms occurring with COVID while accounting for pre-infection symptoms. We use a sample representing the U.S. community population from the Understanding America Study COVID-19 Survey, which surveyed around 8,000 respondents bi-weekly from March 2020 to March 2021. Our final sample includes 308 infected individuals who were interviewed one month before, around the time of, and 12 weeks after infection. About 23% of the sample experienced new-onset symptoms during infection which lasted for more than 12 weeks, and thus can be considered as having long COVID. The most common persistent new-onset symptoms among those included in the study were headache (22%), runny or stuffy nose (19%), abdominal discomfort (18%), fatigue (17%), and diarrhea (13%). Long COVID was more likely among obese individuals (OR = 5.44, p < 0.001) and those who experienced hair loss (OR = 6.94, p < 0.05), headache (OR = 3.37, p < 0.05), and sore throat (OR = 3.56, p < 0.05) during infection. Risk was unrelated to age, gender, race/ethnicity, education, current smoking status, or comorbid chronic conditions. This work provides national estimates of long COVID in a representative sample after accounting for pre-infection symptoms.
Sleep disturbance is associated with neck pain: a 3-year longitudinal study after the Great East Japan Earthquake
Authors: Yabe Yutaka , Hagiwara Yoshihiro , Sekiguchi Takuya , Sugawara Yumi , Tsuchiya Masahiro , Yoshida Shinichirou , Tsuji Ichiro
Published: March 2022

Background: Neck pain is a common health problem in the general population as well as in people after natural disasters. Sleep disturbances are gaining attention as risk factors for musculoskeletal pain; however, the association between sleep disturbance and neck pain has not been clarified. The present study aimed to clarify the association between sleep disturbance and neck pain, especially focusing on the effect of the duration of sleep disturbance. Methods: This study used 3-year longitudinal data obtained from individuals (n = 2,059) living in disaster-affected areas after the Great East Japan Earthquake. Sleep disturbance and neck pain were investigated at 4, 5, 6, and 7 years after the disaster. Multiple logistic regression analyses were used for the assessment.Results: Sleep disturbance was significantly associated with neck pain, and the association was stronger as the duration of sleep disturbance increased (adjusted odds ratios [95% confidence intervals]: 1.84 [1.23-2.75] for “<1 year”; 2.41 [1.53-3.81] for “≥1 year and <2 years”; 2.80 [2.09-3.76] for “≥2 years”). Furthermore, preceding sleep disturbance was significantly associated with the onset of neck pain, and the association was stronger as the duration of sleep disturbance increased (adjusted odds ratios [95% confidence intervals]: 1.86 [1.08-3.20] for “< 1 year”; 2.39 [1.22-4.70] for “≥ 1 year and < 2 years”; 3.00 [1.94-4.65] for “≥ 2 years”).Conclusions: Sleep disturbance is associated with neck pain, and long-lasting sleep disturbance strengthens the association. Clinicians should consider this association to effectively treat patients with neck pain.