bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Sanksi Terhadap Pengemis Di Jalan Umum Berdasarkan Pasal 504 Kitab Undang-Undang Hukum Pidana di Wilayah Hukum Kota Jambi
Authors: Suzanalisa Suzanalisa , Supeno Supeno , Kusumo Wartono Triyan
Published: March 2024

The Jambi City Government has regulated the handling of beggars on public roads in Article 504 of the Criminal Code. Of the many beggars in Jambi City, not all of them have been rehabilitated through the Jambi City Social Service and not a single beggar has been sanctioned on Jambi City's public roads. The aim of this research is to understand and analyze the factors that cause the number of beggars on public roads to increase in Jambi City, the effectiveness of sanctions against beggars on public roads based on Article 504 of the Criminal Code in the jurisdiction of Jambi City and the obstacles and efforts in Minimize begging on public roads in the jurisdiction of Jambi City. The theories used in this writing are effectiveness theory, criminology theory and effort theory. This type of research is empirical legal research. The discussion explains that the factors causing the increase in the number of beggars on public roads in Jambi City are physical condition and age, family economic conditions, employment opportunities, perception of begging, high income, begging is an easy job, strategic location and capital. The effectiveness of sanctions against beggars on public roads based on Article 504 of the Criminal Code in the jurisdiction of Jambi City has not been effective either by the city of Jambi, in this case the Jambi City Social Service, the Jambi City Civil Service Police Unit and the police due to misunderstandings related to the content. Article 504 of the Criminal Code. The obstacles and efforts in minimizing begging on public roads in the Jambi City jurisdiction are the lack of infrastructure and lack of legal understanding among the people of Jambi City. The efforts made are that the Jambi City Social Service formed a team to arrest beggars in Jambi City, carry out raids and train- training carried out by the Jambi City Social Service and the private sector.
Pengaruh Biji Palem Sebagai Bahan Tambah Agregat Kasar pada Beton Terhadap Kuat Lentur
Authors: Bhakti Setya Panca Indra , Ridwan Ahmad
Published: March 2024

In the development of the construction world in the modern era like today, many studies are trying to find alternative materials both as added ingredients and substitutes for concrete dough mixtures. One of the ingredients that can be used as added material is palm seeds that have dried, because palm seeds have not been widely used and used, and make the population become waste around the community because when the palm fruit is dry it will fall scattered around the palm tree. Therefore, palm seed research is held as an added material for coarse aggregate in concrete, with the hope of reducing palm seed organic waste and also efforts to minimize the use of natural rock materials.This study aims to determine the results of the bending strength of normal concrete blocks with a size of 60cm x 15cm x 15cm with added palm seeds of 1.5% 2.5% 3.5%. And the results of the study are in normal concrete bending strength worth 4.298 Mpa, in the variant of added material 1.5% worth 3.501 Mpa, in the variant 2.5% worth 3.172 and in the variant 3.5% has a value of bending strength 2.961 Mpa. So the result of bending strength can be seen that the higher the percentage of added material palm seeds, the lower the bending strength. And in the percentage of added ingredients of palm seeds 1.5%, 2.5%, and 3.5% there is no increase in strength, palm seeds cannot be used as a substitute for coarse aggregate.
Pengaruh Pemanfaatan Kulit Kerang Sebagai Pengganti Sebagian Agregat Halus dengan Menggunakan Pasir Pantai Terhadap Kuat Tekan Beton dan Mutu K-200
Authors: Ramadhan Sya'i , Arif Samsul
Published: March 2024

The influences of shells utilization as smooth aggregate replacement by using sands beach on the concrete compressive strength and the quality of k-200, the use of smooth aggregate substitutes, such as manually broken clam shells and beach sand obtained from Paciran, Lamongan Regency. The mixture used in making concrete is concrete with quality K-200 (fc'16.60 Mpa). Concrete sand will be replaced by 50% with beach sand, and mixed variations will be carried out with the addition of shells by 10%, 15%, and 20%. The test results show that the average compressive strength of normal concrete is 16.60 Mpa. For a mixture with shell waste by 10% and sea sand by 50%, the average compressive strength value is 15.09 Mpa. In a mixture with shell waste by 15% and sea sand by 50%, the average compressive strength value is 14.62 Mpa. While in a mixture with shellfish waste of 20% and sea sand of 50%, the average compressive strength value is 14.13 Mpa. The concrete variant with the highest average compressive strength value is the normal variant with a value of 16.60 Mpa, while the concrete variant with the lowest average compressive strength value is the variant with shell waste of 20% and sea sand of 50%, with a value of 14.13 Mpa.
Pengaruh Penambahan Variasi Limbah Serat Pelepah Pisang terhadap Kuat Lentur Beton
Authors: Rohman Ahmad , Damara Bobby
Published: March 2024

Concrete is a material that is often used for the construction of building structures, bridges and others. Concrete consists of a mixture of fine aggregate (sand), coarse aggregate (gravel), water and cement. In addition to these materials, concrete is usually also mixed with additional materials. In this study, stone banana stem fiber was used as an additional ingredient in the concrete mix. This study aims to determine the composition of the banana stem fiber mixture in concrete, as well as to determine the cracking behavior of the concrete during testing after the addition of banana stem fiber to the concrete mixture. The purpose of this study was to determine and analyze the results of the compressive strength test of concrete, normal concrete and banana fiber mixed concrete. The method used is an experimental method with variations of banana tree fiber, namely 0% (normal concrete); 0.25% and 0.5%. In this test, the specimen model was used, namely a test object measuring 60x15x15 cm. The tests carried out were the flexural strength of the concrete which was carried out after the concrete reached the age of 28 days and the shrinkage test which could be seen visually. From the results of the study it was found that the more the mixture of banana fiber waste, the flexural strength value of the concrete decreased, starting from normal concrete with a value of 49.73 MPa, a mixture of 0.25% with a value of 28.63 MPa, and a mixture of 0.5% with a value of 27.19 Mpa.
Daya Tahan Coldmix Asphalt Sebagai Bahan Darurat Penanganan Jalan dengan Bahan Resin Fiberglass Sebagai Pengganti Aspal
Authors: Maulana Achmad Hanif , Damara Bobby
Published: March 2024

Asphalt is a material that is widely used in road construction. The use of asphalt materials is getting higher, but the asphalt materials used are increasingly expensive and limited, research was conducted with Coldmix Ashpalt with the addition of fiberglass resin with the aim of determining the effect of adding fiberglass resin to AC-WC asphalt materials. The method used for research is carried out in the laboratory with the marshall test method then obtained the calculation results, namely the marshall quotient. The characteristics of AC-WC pavement mixtures include density, cavities in aggregate minerals (VMA), asphalt filled cavities (VFA), voids in the mixture (VIM), stability, marshall melt (flow), and Marshall Quotient (MQ). The results of the study of 4 variations of the deep fiberglass resin mixture used with variation values of 0%, 2%, 3%, 4%. for the variation value that has the highest stability is found in the 3% variation with a stability value of 1577.33 kg, with a VMA value of 15.50%, VFA value of 87.18%, VIM value of 3.28%, flow value of 3.13 mm, and MQ value of 510.72 kg / mm. The variation content of 3% is declared the most effective for mixing AC-WC asphalt because the values of the marshall properties meet the 2018 Highways engineering specifications, so that the most optimal variation of fiberglass resin added material is used as a mixture of AC-WC asphalt with a penetration of 60/70.
Analisa Manajemen Waktu Pekerjaan Renovasi Pembangunan Cafe Terakota
Authors: Al-bab Ulul , Hepiyanto Rasio
Published: March 2024

Successful execution of a construction project on time is one of the most important goals, for both owners and contractors. As in the construction of terracotta cafee renovation work which regressed to week 14, causing inaccuracies between the planning schedule and the construction implementation schedule. This study aims as an evaluation to get the fastest time acceleration using the CPM (Critical Path Method) cut and crashing method. From schedule data, RAB, and analysis of wage prices and weekly progress, a network is created and determines the critical path to then be cut and crashed. From the results of the study, it was found that the acceleration of the project can be done up to 77 days 6 days faster than normal days, which are 83 days with an acceleration cost of Rp. 337,649,065.79 or an increase of Rp. 20,125,000 from the normal cost of Rp. 317,524,065.79. The percentage of comparison due to the acceleration of the project using the critis cut and crash path method, that is, for an acceleration time of 5.59% faster than normal time. Meanwhile, the acceleration fee is 6.34% greater than the normal cost. So with this research, the costs incurred become more expensive, but the project completion time becomes shorter and more concise. It done on July 2rd, 2023.
Pengimplementasian Sistem Building Information Modelling Pada Tahapan Penjadwalan Gedung PUT PNJ
Authors: Afriani Budi , Widiasanti Irika , Wangi Intan Puspa
Published: March 2024

In the process of achieving goals, projects have characteristics called triple constraints, including specific target time, cost, and performance requirements. The delay in the completion process in a project is what will disrupt the triple constraint which has an impact on waste. One of the reasons is that the project still uses conventional methods. This research was conducted to provide information related to conventionally designed scheduling and with the implementation of Building Infortmation Modeling (BIM), namely using several supporting software including, Naviswork, Microsoft Project and Revit at the scheduling stage of multi-storey buildings, namely at the PNJ PUT Laboratory Building. The results showed that the elaboration of scheduling planning using BIM is more efficient, easy to understand, and provides a visualization of the construction sequence and avoids waste. Then, some of the percentage of waste obtained if using conventional methods is, around 10% on materials, 40% of projects are over budget, 30% of projects are reworked, and almost 90% of projects are delayed. Thus, the implementation of BIM in project scheduling is very important to overcome things that can harm a project.
Kinerja Jalan Tingang Kota Palangka Raya dengan Metode Pedoman Kapasitas Jalan Indonesia 2014
Authors: Setiawan Rizky Wahyu , Elvina Ina , Supiyan Supiyan
Published: March 2024

Population growth is usually accompanied by an increase in the activities of all communities in an area. Community activities require facilities and infrastructure to support the activities carried out. Transportation is an important activity for the community. Therefore, the existence of a private car is a necessity. Congestion often occurs during peak hours and some of the main roads in Palangka Raya City, such as Tingang Road, experience a significant increase in car traffic. Tingang Road is an important road for the local community because it is an access to residential areas, schools, sub-districts and an alternative road out of the city via Mahir Mahar Road or the outer ring road. The purpose of this study is to analyze and evaluate road performance. This research uses a direct survey method carried out to the field in order to obtain precise information about a condition. After primary and secondary data collection is collected, analysis is carried out using PKJI 2014. Thus, based on the results of the analysis, the performance of the road can be known. The traffic volume is 546.85 skr / hour which occurs during the day, 11:45 to 12:45 WIB. The current capacity is 1667.98 skr/hr. Meanwhile, the degree of saturation is calculated at 0.327, which indicates level of service B, which indicates a good level of road service.
Monitoring Dan Evaluasi Jaringan Drainase Yang Ramah Lingkungan Di Perumahan Villa Delima Mayang Kota Jambi
Authors: Mariansyah Mariansyah , Das Amsori M , Dony Wari , Fadlan Fadlan , Azanna Dwitya Okky
Published: March 2024

The rainy season, which has a fairly high frequency over a long period of time, results in the need for drainage so that the amount of rainwater can be channeled into water bodies and some of it can be used for purposes in daily life. This is so as not to cause inundation and flooding problems. This research aims to analyze the condition of the existing drainage network, calculate runoff discharge, plan infiltration wells for utilizing rainwater in the Villa Delima Mayang housing complex, Jambi City. The method used in this planning uses hydrological analysis calculations including mononobe, pearson III and rational log methods. In planning infiltration wells, it refers to the Indonesian National Standard (SNI) No. 03-2453-2002. The result of the 10 year return period design rainfall is 112.17 mm. the results of the analysis of the carrying capacity show that 9 out of 14 channels are unable to accommodate the 10 year return period design discharge. Next, an absorption well with a diameter of 0.8 meters and a depth of 1.5 meters is planned and placed in a drainage channel that cannot accommodate runoff. The absorption capacity of 1 well is 0.7536 m3.
Comparison of Using Conventional Estimating and Sketchup Pro for Bill Quantity Takeoff Process
Authors: Diandra Nadia , Ceisya Daffira , Farid Farid
Published: March 2024

Departing from academic anxiety that the construction industry in Indonesia has made rapid progress with the adoption of computing technology and methods in recent years. Increasing infrastructure development encourages construction actors to effectively and efficiently improve project quality. However, the role of the quantity surveyor becomes crucial in facing challenges such as manual quantity picking which is prone to errors and cost estimation that is difficult to do based on rough schematic design. In the context of traditional construction projects, quantity lists are arranged based on 2D drawings, but the use of 3D models has diminished since the adoption of BIM. Sketchup, as a 3D modeling software, and its extension Quantifier Pro provide a solution by combining 3D models to produce accurate quantity takeoff calculations on the Bill of Quantity. This research aims to develop methods to improve the quantity accuracy of elements of an incomplete or incorrect Sketchup model, in the hope of reducing modeling time, improving quantity retrieval performance, and making Sketchup-based cost estimation more effective and efficient in the context of construction. This research method involves 3D modeling using the Sketchup Pro application, using secondary data in the form of Detailed Engineering Design (DED) working drawings. Volume calculation in the Bill of Quantity is done with the help of Sketchup Pro software. The research location is in the Mullberry Cluster residential project, Bekasi City, West Java. The house building in this project was chosen as an object of comparison between conventional calculation methods and calculation methods using Sketchup Pro software. The main focus is to overcome the challenges of manual quantity picking and cost estimation from rough schematic design, emphasizing the crucial role of quantity surveyors. The results showed that the use of 3D models in Sketchup can increase the accuracy of cost estimation and reduce modeling time. The conclusion of the study confirms that Sketchup as an effective alternative solution in increasing efficiency and accuracy in the construction process, especially in the context of taking the quantity of architectural work elements, contributes positively to the development of more sophisticated cost estimation methods in the Indonesian construction industry.
Pemanfaatan Kombinasi Limbah Fly Ash dan Bottom Ash Dalam Campuran Mortar Untuk Paving Block
Authors: Khairizal Yuri , Ibrahim Ibrahim , Fikri Julian , Wiranata Didi Yuda , Amanah Tody , Mahmuda Mahmuda , Sumiati Sumiati
Published: March 2024

Various alternative solutions to reduce waste continue to be sought and developed. This includes fly ash and bottom ash which are waste products from burning coal, one of which is produced by Steam Power Plants (PLTU). So the increasing need for electricity will also be followed by an increase in the amount of waste. This type of waste is utilized in various fields of science, such as agriculture, industry and quite a lot in the construction sector. As a field that continues to develop along with people's need to live and move, utilization in the construction sector has great potential as a solution to reduce this waste. The use of fly ash and bottom ash in construction material mixtures as a quality enhancer or simply to reduce the use of natural materials continues to be carried out. This research will focus on the utilization of waste at a large percentage on a construction product scale. Substitution in the composition of the mortar mixture which is the initial product shows the effect of improving quality at a relatively low percentage in the variations used in this research. However, the full substitution of this waste as a substitute for natural materials, namely fine aggregate, is still in a fairly good range, especially in the composition of mortar mixtures with relatively low quality targets or in composition ratios with more aggregate material than cement or binder.
PELATIHAN PENGGUNAAN GOOGLE FORM DAN GOOGLE CLASSROOM SEBAGAI SOLUSI PEMBELAJARAN ONLINE DI TENGAH PANDEMIK COVID-19
Authors: Wisman Wisman , Youpika Fitra , Qalbi Zahratul
Published: March 2024

Belajar online merupakan tantangan pada saat pandemik Covid-19 karena belajar online membutuhkan profesionalitas dan kualitas guru. Pembelajaran berbasis online menjadi solusi di tengah wabah covid-19. Demi meningkatkan efektivitas dan efisiensi pembelajaran pada saat Covid-19 di SMKN 7 Kota Bengkulu perlu dikembangkan berbagai media pembelajaran yang kreatif dan inovatif berbasis online terutama menggunakan google form dan google classroom. Berdasarkan fenomena tersebut, tujuan pengabdian ini sebagai berikut. (1) Guru bisa menerapkan pembelajaran secara online dengan menggunakan google form dan google classroom; (2) Guru bisa menggunakan teknologi dalam mempublikasikan bahan ajar, selama ini guru mengajar secara konvensional yaitu harus dengan melakukan tatap muka; dan (3) Guru tidak lagi menggunakan kertas pada saat latihan atau ujian.
SOSIALISASI LITERASI DIGITAL BAGI ORANG TUA DAN GURU PAUD MUTIARA CENDEKIA
Authors: Novitasari Yesi , Wahyuni Sri , Suharni Suharni
Published: March 2024

Hadirnya Teknologi digital berbasis revolusi industry 4.0 memberikan keuntungan dan menawarkan banyak peluang pada dunia tanpa batas yang belum pernah ada sebelumnya. Namun juga mempunyai berbagai dampak buruk jika tidak diiringi pengetahuan dan kecakapan yang cukup. Sistem pembelajaran dan sistem multi media yang dapat menunjang perubahan sistem pendidikan yang klasik menjadi sebuah pembelajaran berbasis online dengan sistem pola pembelajaran e-learning dan virtual meeting, dan ini merupakan tantangan super baru dalam kancah dunia Pendidikan. Namun demikian diperlukan literasi digital bagi guru, orang tua dan anak agar tujuan pemanfaatan digitalisasi dalam pembelajaran tercapai dan terhindar dari hal yang tidak diinginkan. Pada pendidikan PAUD, anak lebih diperkenalkan pada realitas hidup bersama yang mempunyai aturan dan nilai hidup. Proses ini dilaksanakan melalui berbagai bentuk kegiatan yang membuat anak senang dan merasakan kebaikan dan tatanan serta nilai hidup tersebut. Namun disituasi dan kondisi berbeda guru tetap dituntut menyuguhkan pembelajaran bermakna untuk anak, tatap muka ataupun kelas yang mengudara dengan pemanfaatan digital. Untuk itu diperlukan literasi digital bagi orang tua, guru dan siswa agar dapat saling mendukung dan melakukan peranannya masing-masing dalam pemanfaatan digital sehingga pembelajaran dapat berjalan baik sesuai perencanaan dan dapat mencapai perkembangan optimal.
Effect Of Good Corporate Governance (GCG), Corporate Social Responsibility (CSR) Disclosure, And Intellectual Capital On Tax Avoidance
Authors: Novri Rahmi  , Azwirman  , Novriadi
Published: March 2024

Tax avoidance is a legal and safe strategy for taxpayers, since it does not conflict with the established tax terms. This study aims to test and analyze the effect of corporate governance by selecting variabel of the board of independent commissioners and auditing committees, disclosure of social responbility and intellectual capital on tax evoidance on transport and logistics companies registered at the Indonesian stock exchange 2019-2021. The study includes quantitative work with an associative approach that uses detailed financial statements annully. The population of the study included 30 transport and logistics companies listed in the Indonesia stock exchange period 2019-2021. Research sample were selected using purposive sampling technique to be obtained by 10 companies that met the study criteria over a time span of 20192021. Data analysis uses a double linear regression analysis techniques in which result significantly variable independent council of commissioners, auditing committees, and disclosure of social responbility do not affect tax avoidance. Whereas intellectual capital variables have significant impact on tax avoidance. Simultaneous variables of the independent council of commissioners, auditing committees, disclosure of social responbility and intellectual capital affect tax avoidance.
Exploration of Social Accounting Disclosures: A Bibliometric Analysis Perspective
Authors: Muthohirin  , Rahayu Kanthi Riska , Priristia Fahayu
Published: March 2024

This study reviews the literature related to social accounting disclosures with the aim of mapping the research that has been done, providing insight into research trends, providing an overview of research themes, identifying the most cited authors and journals, evaluating the most active affiliations and countries in discussing social accounting reporting disclosures, and providing a basis for future research directions. Data analysis was conducted using bibliometric methods by collecting data from 188 articles contained in journals indexed in the Scopus database. RStudio was used as software to analyze the data and break down research trends by author, journal, affiliation, country, and keywords, providing insights into future research opportunities. The review showed an increase in publications since 2003, with Khaled Hussainey and Mathias Laine as the most active authors and Khaled Hussainey as the most impactful author. The most relevant journal in this context is Accounting, Auditing, and Accountability. The University of Naples Parthenope is the most relevant affiliation regarding publications in this field. In addition, the UK plays a leading role in this literature both in terms of the number of published works and the most cited ones. The most relevant keywords are corporate social responsibility, sustainability, and sustainable development. The implications of this study are significant for researchers interested in social accounting disclosures. The study provides a comprehensive overview of the research that has been done in this field, identifying research trends, themes, and the most cited authors and journals. This information can be used to guide future research directions and to identify areas where further research is needed
Habilidades lúdicas y su incidencia en el desarrollo del pensamiento crítico
Authors: Llerena-Garces Belen , Hernández-Del Salto Segundo , Torres-Chiliquinga Luzmila , Morales-Zuñiga Humberto
Published: March 2024

La presente investigación trata sobre las habilidades lúdicas en el desarrollo del pensamiento crítico, así a la actividad lúdica como aquello que se puede realizar en el tiempo libre, su objetivo es liberar tensiones, salir de la rutina diaria y obtener un poco de placer, diversión y entretenimiento;  la aplicación de habilidades lúdicas facilitará el desarrollo del pensamiento crítico en los estudiantes, el cual se verá reflejado en el rendimiento académico escolar y el medio social donde se desenvuelve.

La metodología aplicada en la presente investigación es cualitativa ya que se basa la recopilación de datos obtenidos anteriormente y poder ser analizados de manera que permita dar una solución a la problemática dada en el presente caso, dando como resultado la aplicación de varias estrategias que se pueda aplicar y que permitan el desarrollo del pensamiento crítico, además que los estudiantes podrán mejorar su rendimiento académico.

De tal manera se concluye que las Habilidades Lúdicas juegan un papel muy importante cuando se trata de despertar interés en los niños, ellos sirven para iniciar una clase, para explicar una temática nueva o para evaluar alguna competencia adquirida, tomando en cuenta que el interés de los niños por el aprendizaje es un bien muy frágil, se consigue con mucha facilidad pero así mismo se pierde y luego es prácticamente imposible recuperarlo ya que adquirir conocimiento, demanda de un gran esfuerzo de la voluntad y que muchas veces los niños no saben cuál es el fin y razón de sus aprendizajes.
Inteligencia emocional de los estudiantes mediante el uso de estrategias lúdicas
Authors: Olmos-Borja Lina , Araujo-Reyes Adriana , Burgos-Tipán Sonia , Romero-Peña Sandra
Published: March 2024

La presente investigación aborda como temática principal la importancia de la inteligencia  emocional como requisito fundamental  en el éxito personal y social, al mismo tiempo que se destaca la utilidad de las estrategias lúdicas como herramienta fundamental para desarrollar la inteligencia emocional en estudiantes y de esta manera alcanzar un desarrollo integral de la persona en todos sus ámbitos. Para cumplir con este objetivo se comienza con un análisis por separado de la inteligencia emocional y las estrategias lúdicas. Posteriormente se realiza una descripción detallada de la relación entre Inteligencia Emocional y Estrategias Lúdicas, evidenciando la necesidad de incluir contenidos al respecto tanto en la formación docente como de forma transversal en la educación a nivel escolar y universitario.
Hábitos de estudio y el desempeño académico de estudiantes
Authors: Pallo-Pilalumbo Sandra , Mayorga-Ases Maria , Hernández-Del Salto Segundo , Melo-Fiallos Diego
Published: March 2024

En el presente artículo se ha recopilado información acerca de los hábitos de estudio y el rendimiento académico de los estudiantes, definiéndose así a las prácticas de aprendizaje como las distintas estrategias que utilizan para cumplir con sus tareas, poner atención en clase, motivarse y plantearse metas educativas ,siendo lo primordial para tener un alto nivel de rendimiento académico, para ello se realizó una búsqueda de  revisión de la literatura en diferentes fuentes bibliográficos como: artículos, libros, papers científicos Scopus, Redalyc, Scielo, Dialnet y Web Of Science ,mediante el cual se obtuvo un análisis sobre las investigaciones realizadas como tal en periodos anteriores , de modo que nos arrojó datos relevantes sobre la falta de implementación sistemática de hábitos de estudio efectivos, adaptados según la formación de cada individuo, y la creación de entornos propicios para educación dentro de la institución .La investigación también se centra en las técnicas de lectura activa y la repetición que, muestran una influencia significativa en el desempeño estudiantil. Estas estrategias no solo mejoran las calificaciones, sino que también promueven una comprensión profunda y una retención más sólida en el aprendizaje.
High-Volume Hospital Had Lower Mortality of Severe Intracerebral Hemorrhage Patients
Authors: Park Sang-Won , Han James Jisu , Heo Nam Hun , Lee Eun Chae , Lee Dong-Hun , Lee Ji Young , Lee Boung Chul , Lim Young Wha , Kim Gui Ok , Oh Jae Sang
Published: March 2024

Objective : Intracerebral hemorrhage (ICH) accompanies higher mortality rates than other type of stroke. This study aimed to investigate the association between hospital volume and mortality for cases of ICH.Methods : We used nationwide data from 2013 to 2018 to compare high-volume hospitals (≥32 admissions/year) and low-volume hospitals (<32 admissions/year). We tracked patients’ survival at 3-month, 1-year, 2-year, and 4-year endpoints. The survival of ICH patients was analyzed at 3-month, 1-year, 2-year, and 4-year endpoints using Kaplan-Meier survival analysis. Multivariable logistic regression analysis and Cox regression analysis were performed to determine predictive factors of poor outcomes at discharge and death.Results : Among 9086 ICH patients who admitted to hospital during 18-month period, 6756 (74.4%) and 2330 (25.6%) patients were admitted to high-volume and low-volume hospitals. The mortality of total ICH patients was 18.25%, 23.87%, 27.88%, and 35.74% at the 3-month, 1-year, 2-year, and 4-year, respectively. In multivariate logistic analysis, high-volume hospitals had lower poor functional outcome at discharge than low-volume hospitals (odds ratio, 0.80; 95% confidence interval, 0.72–0.91; p<0.001). In the Cox analysis, high-volume hospitals had significantly lower 3-month, 1-year, 2-year, and 4-year mortality than low-volume hospitals (p<0.05).Conclusion : The poor outcome at discharge, short- and long-term mortality in ICH patients differed according to hospital volume. High-volume hospitals showed lower rates of mortality for ICH patients, particularly those with severe clinical status.
Improving the psychosocial risks management process taking into account the influence of dangerous factors: discrimination, mobing and sexism
Authors: Tsopa Vitaly , Cheberyachko Serhii , Yavorska Olena , Deryugin Oleg , Sokurenko Svitlana , Sharovatova Olena
Published: March 2024

Purpose: is the development of a psychosocial risk management model taking into account various dangerous factors such as mobbing, sexism and discrimination and development of appropriate preventive measures, including legislative requirements.

Method: general scientific and special legal methods of scientific knowledge, the formal legal method.

Findings: An effective methodology for managing psychosocial risks has been developed, taking into account various dangerous factors, such as mobbing, sexism, discrimination and appropriate preventive measures, including legislative requirements

Practical implications: lies in the development of recommendations for reducing negative phenomena in the organizational culture of business facilities, which involve the creation of a safe and comfortable workplace, both physically and psychologically.

Paper type: theoretical, descriptive, methodical.
LANTHANIDE CONTRACTION IN CHELATES OF ETHYLENEDIAMINETETRAACETIC ACID BASED ON CRYSTALLOGRAPHIC DATA: A SHORT REVIEW
Authors: Noguchi Daisuke
Published: March 2024

The lanthanide (Ln) series has been attracted so much attention not only for its physical properties but also for its applications in organic synthesis and biomedical engineering. In the lanthanide chemistry, lanthanide contraction is a crucial concept meaning the gradual decrease in ionic radii as the atomic number of the Ln series increases. As a prominent chelator, ethylenediaminetetraacetic acid (EDTA) has been well-known to give stable complexes with various metals including Ln ions, resulted in forming (EDTA−4H)4− anion by deprotonation; over 100 kinds of Ln-EDTA complexes have hitherto been synthesized and structurally characterized using X-ray crystallography. While the lanthanide contraction phenomenon has been extensively studied in certain complexes of Ln, systematization on the Ln-EDTA remains inadequate though the chelates of EDTA are commonly used. Thus, this study presents a comprehensive analysis based on the data from the Cambridge Crystallographic Data Centre (CCDC). In mononuclear EDTA complexes X[Ln(EDTA−4H)(H2O)m]·nH2O (X+ = NH4+and its analogues) systematic lanthanide contraction depending on their coordination number are presented except for a few cases. However, in the case of non-mononuclear complexes or coordination polymers, the compositions become more complicated, and a greater variation in atomic bond length occurs, which is unusual for the lanthanide contraction studies in previous research. These varieties are considered to be influenced by different types of counter-cations, inorganic anions, solvent molecules and bridging O atoms from another EDTA anions. This suggests the flexibility and versatility of EDTA as a ligand. Such findings in the Ln-EDTA complexes could potentially provide us further development of a novel function in the future.
STUDY OF PROCESSES OF MODIFICATION OF THE SURFACE OF TiO2 NANOPOWDER UNDER THE ACTION OF HYDROGEN PEROXIDE.
Authors: Trachevskii Volodymyr , Korduban Oleksandr , Stanculescu Anca
Published: March 2024

Using the methods of X-ray photoelectron spectroscopy, nuclear magnetic resonance, IR-spectroscopy and atomic force microscopy, the electronic structure and surface morpho­logy of TiO2nanopowders synthesized by the EEW method were investigated. The samples were exa­mined before and after their modification with hydrogenperoxide. This information is relevant for the development of methods of self-doping of oxide matrices with anexcess of oxygen in order to create active centers on the surface in the form of peroxide groups, which leads to the appearance of TiO2 photo activities in the visible light region. Taking into account the possibility of detection of both reducing and oxidizing functions by hydrogenperoxide, the effect of hydrogen peroxide on the TiO2 surface under different modes of modification was investigated.

The influence of the degree of hydration (Оlat./Оads.) of the original oxide matrix on the binding energy and the relative changes in the contributions of different types of oxygen peroxogroups of hydrogenperoxide-modified TiO2 were determined using XPS. In the paper, the corresponding O1s spectra were obtained and the E energies and integral intensities of the corresponding components were determined, the value of the Оlat./Оadsratio for unmodified and modified samples was given. It was established that for a series of TiO2 samples, the ratio of integral intensities of peroxo groups in the O1s spectra is preserved. For the first time, the O1s spectrum of titanium peroxide was inter pretedin terms of the O-O form of oxygen. The mechanism of action of hydrogen peroxideon the metal oxide matrix is proposed, which is determined by the degree of blocking of themain O2centers of the oxide matrix by the OH groups present in it, which leads to a change in the direction of redox transformations.
Design and Development of Electromagnet Power Supply for Burst Mode Repetitive High Power Microwave Sources
Authors: Kumar Ranjeet , Mitra S. , Patel A. S. , Senthil K. , Beg Mirza Danish , Roy A. , Bakhtsingh R. I.
Published: March 2024

Single frequency High-power microwave sources like Backward Wave Oscillator, Relativistic Magnetron etc., require a high magnetic field of about 1T to 4T for efficient operation. Single-shot HPM systems usually consist of pulsed magnetic systems. However, for repetitive HPM generation, a continuous magnetic field is required. To obtain a continuous high magnetic field in the required volume usually three solutions are worldwide preferred i.e., permanent magnet, DC electromagnet with cooling arrangements and superconductor-based magnetic coil. All these three systems are bulky, expensive and technologically demanding. In this paper, a novel power supply has been suggested that discharges a charged capacitor through a magnetic coil keeping the discharging current constant for a small period like hundreds of milliseconds to a second. An IGBT switch is used to discharge the capacitor1. The duty cycle of the IGBT switch is controlled using a current feedback signal from the hall sensor, thus keeping the current steady at a preset reference value. An experimental setup has been developed using a 300mF capacitor. A constant current up to 500A is achieved for 200mS. This system is scalable. For a longer duration of operation, more capacitor modules need to be added. Details of design, development and experimental results are presented in this paper.
Conjugation of an anti-metabolite nucleobase analogue with a mitochondriotropic agent via palladium(II) against breast cancer cells
Authors: Banti C. N. , Tasiopoulos A. J. , Hadjikakou S. K.
Published: March 2024

The conjugation of the uracil (a nucleobase) analogue, 6-methyl-thiouracil (MTUC), with the mitochondriotropic agent of Tri-o-Tolyl-Phosphine (TOTP) through palladium(II) leads to the formation of the metallodrug of formula [PdCl(TOTP)(MTUC)] (1). The metallodrug was characterized in solid state using Attenuated Total Reflectance-Fourier Transform Infra-Red (ATR-FTIR) spectroscopy and X-ray diffraction crystallography (XRD), while its behavior in solution was examined through Ultra Violet (UV) and 1H NMR spectroscopies. The in vitro cytotoxicity of 1 was assessed against human breast adenocarcinoma cell lines: MCF-7 (hormone-dependent (HD)) and MDA-MB-231 (hormone-independent (HI)), as well as fetal lung fibroblast (MRC-5) cells. The MCF-7 cell morphology suggests apoptotic pathway, and this was confirmed by Acridine Orange/Ethidium Bromide (AO/EB) Staining, and the loss of the permeabilization of the mitochondrial membrane. The binding affinity of 1 toward the calf thymus (CT) DNA was clarified.
Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells
Authors: Sergeeva O. , Akhmetova E. , Dukova S. , Beloglazkina E. , Uspenskaya A. , Machulkin A. , Stetsenko D. , Zatsepin T.
Published: March 2024

Phosphorothioate (PS) group is a key component of a majority of FDA approved oligonucleotide drugs that increase stability to nucleases whilst maintaining interactions with many proteins, including RNase H in the case of antisense oligonucleotides (ASOs). At the same time, uniform PS modification increases nonspecific protein binding that can trigger toxicity and pro-inflammatory effects, so discovery and characterization of alternative phosphate mimics for RNA therapeutics is an actual task. Here we evaluated the effects of the introduction of several N-alkane sulfonyl phosphoramidate groups such as mesyl (methanesulfonyl) or busyl (1-butanesulfonyl) phosphoramidates into gapmer ASOs on the efficiency and pattern of RNase H cleavage, cellular uptake in vitro, and intracellular localization. Using Malat1 lncRNA as a target, we have identified patterns of mesyl or busyl modifications in the ASOs for optimal knockdown in vitro. Combination of the PSMA ligand-mediated delivery with optimized mesyl and busyl ASOs resulted in the efficient target depletion in the prostate cancer cells. Our study demonstrated that other N-alkanesulfonyl phosphoramidate groups apart from a known mesyl phosphoramidate can serve as an essential component of mixed backbone gapmer ASOs to reduce drawbacks of uniformly PS-modified gapmers, and deserve further investigation in RNA therapeutics.
Functional characterization of Francisella tularensis subspecies holarctica genotypes during tick cell and macrophage infections using a proteogenomic approach
Authors: Schütz Sara Doina , Brackmann Maximilian , Liechti Nicole , Moser Michel , Wittwer Matthias , Bruggmann Rémy
Published: March 2024

Tularemia is a vector-borne disease caused by the Gram-negative bacterium Francisella tularensis. Known hosts and vectors in Europe are hare and ticks. F. tularensis is transmitted from ticks and animals, but also from the hydrotelluric environment and the consumption of contaminated water or food. A changing climate expands the range in which ticks can live and consequently might contribute to increasing case numbers of tularemia. Two subspecies of F. tularensis are human pathogenic. Francisella tularensis tularensis (Ftt) is endemic in North America, while Francisella tularensis holarctica (Fth) is the only subspecies causing tularemia in Europe. Ft is classified as a category A bioterrorism agent due to its low infectious dose, multiple modes of transmission, high infectivity and potential for airborne transmission and has become a global public health concern. In line with the European survey and previous phylogenetic studies, Switzerland shows the co-distribution of B.6 and B.12 strains with different geographical distribution and prevalence within the country. To establish itself in different host environments of ticks and mammals, F. tularensis presumably undergoes substantial changes on the transcriptomics and proteomic level. Here we investigate the transcriptomic and proteomic differences of five strains of Fth upon infection of rabbit macrophages and tick cells.
Approaching tourism communication with empirical multimodality: exploratory analysis of Instagram and website photography through data-driven labeling
Authors: Mattei Elena
Published: March 2024

This paper reports the methods and results of the manual annotation of visual features in two corpora of tourism photography on travel boards' digital channels with a tailored tagging model based on the Grammar of Visual Design and adapted to tourism discourse. Computational analysis and statistical modeling show how the testing of theoretical assumptions through categorized data may lead to evidence-based interpretations of patterns of data clustering and to the detection of new communicative aims and conventions across digital media. Preliminary findings reveal indeed significant differences in the frequency of tag (co)patternings and use of visual strategies across channels that are related to the role and aim of each channel in the marketing funnel of persuasion and journey toward purchase (AIDA). Instagram imagery was demonstrated to foster a pre-consumption of the travel experience and emotionally charged reactions by representing perceptive and emotive expectations. While both channels play on postmodern tourists' desire for the uncontaminated, remote and the authentic, Instagram favors aerial views of pristine, aesthetically pleasant settings, often complemented with rear views of solitary individuals performing static processes of contemplation of natural wonders. This suggests a focus on attracting the attention and providing instant gratification of the senses by representing what stands in contrast to everyday life and traditional tourist experiences, both avoiding cognitive effort in a pervasive digital sphere with endless sources of information and encouraging further exploration on websites.
Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering
Authors: Capra Nikolas , Lelièvre Chloé , Touré Océane , Fossey-Jouenne Aurélie , Vergne-Vaxelaire Carine , Janssen Dick B. , Thunnissen Andy-Mark W. H. , Zaparucha Anne
Published: March 2024

The CoA ligase from Metallosphaera sedula (MsACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help of ATP, followed by the uncatalyzed cleavage of acyl-AMP by a nucleophilic amine to yield an amide. With ω-amino acids as substrates this reaction may result in formation of lactams, but unfortunately the substrate preference of the wild-type enzyme is rather limited. To allow structure-based protein engineering and expand the substrate scope of the enzyme, crystal structures of MsACL were solved in the thioesterification conformational state with AMP, CoA and with the reaction intermediate acetyl-AMP bound in the active site. Using substrate docking and by comparing the crystals structures and sequence of MsACL to those of related CoA ligases, mutations were predicted which increase the affinity in the carboxylic acid binding pocket for ω-amino acids. The resulting mutations transformed a non-active enzyme into an active enzyme for ε-caprolactam synthesis, highlighting the potential of the thermophilic CoA ligase for this synthetic and biotechnologically relevant reaction.
A cross-sectional study investigating the relationship between urinary albumin creatinine ratio and abdominal aortic calcification in adults
Authors: Xue Xian , Li Chen , Chen Dongping
Published: March 2024

Introduction

The presence of abdominal aortic calcification (AAC) is strongly linked to the development of atherosclerosis and the incidence of morbidity and mortality related to cardiovascular diseases (CVD). Urinary albumin creatinine ratio (UACR) was found related with the increased risk of CVD. The aim of this study is to explore the relationship between the UACR and severe AAC (SAAC).

Methods and Results

This study included a total of 2,379 individuals aged over 40 years, and their information was obtained from the National Health and Nutrition Examination Survey conducted (NHANES) in 2013–2014. The measurement of AAC was conducted through dual-energy x-ray absorptiometry and assessed using the Kauppila scoring system. SAAC was characterized by a Kauppila score of 6 or higher. Multivariate regression models were used to analyze the relationship between UACR level and SAAC, with covariate adjustment. In the completely adapted model, the top third subgroup exhibits increased likelihood of SAAC (odds ratio 1.50; 95%CI: 0.98, 2.29; p = 0.030) in contrast to the bottom third subgroup. The subgroup analyses revealed a more pronounced correlation among the older participants (p-value for interaction = 0.013).

Discussion

In the United States, SAAC was more likely to occur in adults who had a higher probability of UACR. The use of UACR has the potential to be a valuable method for forecasting the likelihood of SAAC.