bluuebunny/crossref_metadata_2025 huggingface dataset:
Kapasitas Organisasi dalam Penyelenggaraan Kearsipan di Dinas Perpustakaan dan Kearsipan Kota Bandar Lampung
Authors:   Universitas Lampung, Simanjuntak Ristanti , Hutagalung Simon Sumanjoyo ,   Universitas Lampung, Karmilasari Vina ,   Universitas Lampung
Published: May 2021

Archives in administrative activities have a very important role, one of its functions is as the center of the nation's memory and evidence of legal accountability. However, the implementation of archiving in Indonesia, especially local governments, is currently still less than optimal. In 2017, the organization of archiving in Indonesia received the predicate of 93% in bad condition, for this reason, adequate organizational capacity is needed. Organizational capacity is the ability that an organization has that is useful for solving problems and can achieve the goals set. This research was conducted at the Department of Library and Archives of Bandar Lampung City with the aim of identifying and analyzing these offices in organizing archives. The method used in this research is descriptive qualitative with data analysis techniques derived from observation, documentation and in-depth interviews. The results of this study are described based on the components of organizational capacity consisting of human resources, infrastructure, technology, financial resources, leadership strategies, program and process management, cooperation and relationships with other parties. Organizing the archives of the Bandar Lampung City Library and Archives Service has been carried out since 2008. However, archiving has not been carried out optimally because the capacity of the office is inadequate.
Investigation of Trends in National and International Studies in Higher Education by Means of Big Data and Data Mining: 1965-2019
Authors: İşbulan Onur , Hamutoğlu Nazire Burçin , Kıyıcı Mübin
Published: May 2021

Studies carried out in the field of higher education have taken on the mission of solving the problems of higher education institutions on a global level. This enables institutions to have different perspectives, to keep themselves up-to-date, and to approach problems in higher education with a visionary perspective. In this study, the national and international studies related to higher education between 1965 and 2019 that were included in the ERIC database were examined from a scientometric point of view. The results obtained were evaluated thematically. Analyzing the big data at the micro level in line with the research purpose revealed the trends in the studies conducted in the field of higher education from past to present. Considering these trends, the higher education studies in Turkey mostly focused on the concept of attitude, predominantly employed quantitative methods, and aimed at revealing the existing situation rather than being innovative. 371,771 studies/articles related to higher education in the ERIC database were examined by their type, subject, title, author, target group, and research location. The results obtained differed periodically in their international and national dimensions. The findings were discussed, and some suggestions, such as using different methods, focusing on policy-making rather than the current situation in higher education, and focusing on digitalization in higher education, were made for future studies.
Perbandingan Pengalaman-Preferensi Mahasiswa pada Pembelajaran Online vs Face to Face
Authors: Ismiati Maria Bellaniar , Andayani Sri
Published: May 2021

Abstract. Comparison of Student Experiences-Preferences in Online vs Face to Face Learning. Technology is increasingly developing, especially after the world has been hit by the COVID-19 virus pandemic. In the education sector, the learning process was carried out online, whereas before the pandemic it was carried out face to face. Of the two types of learning, there are often differences of opinion between students about which learning is better and more flexible. Based on this, this research is entitled Comparison of Students' Experience and Preferences on Online vs Face to Face Learning. This study uses a methodology, namely pre-field, field work, and data analysis. Data collection through interviews. Miles and Huberman's model is used for data reduction, data presentation, and conclusion drawing applied in data analysis. The results showed that student preferences for face to face learning were more than online learning, which was 75%, while the comparison of experiences felt by students was> 50% who chose face to face learning.Keywords: Online, Face to Face, Experience, Preference Abstrak. Teknologi semakin berkembang, terutama setelah dunia dilanda oleh pandemi virus COVID-19. Di bidang pendidikan, proses pembelajaran dilakukan secara online sedangkan sebelum pandemi dilakukan secara face to face. Dari kedua jenis pembelajaran tersebut, sering terdapat beda pendapat antar mahasiswa mengenai mana pembelajaran yang lebih baik dan fleksibel. Berdasarkan hal tersebut, penelitian ini berjudul Perbandingan Pengalaman dan Preferensi Mahasiswa terhadap Pembelajaran Online vs Face to face. Penelitian ini menggunakan metodologi yaitu pra lapangan, pekerjaan lapangan, dan analisis data. Pengumpulan data melalui wawancara. Model Miles dan Huberman digunakan untuk reduksi data, penyajian data, dan penarikan kesimpulan diterapkan dalam analisis data. Hasil penelitian menjunjukkan preferensi mahasiswa terhadap pembelajaran face to face lebih banyak daripada pembelajaran online, yaitu sebanyak 75% sedangkan perbandingan pengalaman yang dirasakan oleh mahasiswa adalah sebanyak > 50% yang memilih pembelajaran secara face to face.Kata Kunci: Online, Face to Face, Pengalaman, Preferensi
Perbandingan Pembobotan Kriteria dan Seleksi Kriteria pada Pengelompokan Kinerja Karyawan dengan Fuzzy C-Means
Authors: Sanjaya Rian , Nataliani Yessica
Published: May 2021

Abstract. Comparison of Weighted Criteria and Selection Criteria for Employee Performance Grouping with Fuzzy C-Means. The development of information technology makes it easier for companies to do many things and affect company operations. One of the objects affecting the company development is employees. Employees’ performance can be observed from their discipline, honesty, cooperation, and work quality. The purpose of this study is to group the employees based on their performance using fuzzy c-means. There are two kinds of clustering explained in this paper, i.e., clustering with feature weighting and clustering with feature selection. Using the feature weights of 25%, 30%, 25%, and 20% for work discipline, honesty, cooperation, and work quality, respectively, the clustering with feature weighting gives an accuracy rate of 0.8462. While using feature selection, the fuzzy c-means give 1, where the work discipline and honesty are the critical features in clustering. Therefore, we find that honesty is the most essential feature to cluster the employees based on their performance from this research.Keywords: clustering, employees, fuzzy c-means, feature weighting, feature selectionAbstrak. Perkembangan teknologi informasi mempermudah perusahaan dalam melakukan banyak hal dan mempengaruhi operasional perusahaan. Salah satu objek yang mempengaruhi operasional perusahaan adalah kinerja karyawan. Penilaian kinerja karyawan didasarkan pada empat kriteria, yaitu kedisiplinan, kejujuran, kerja sama, dan kualitas kerja, Tujuan penelitian ini untuk melakukan pengelompokan karyawan dengan fuzzy c-means. Pengelompokan yang dilakukan dalam penelitian ini terdiri dari dua macam, yaitu pengelompokan dengan pembobotan kriteria dan pengelompokan dengan seleksi kriteria. Dengan bobot sebesar 25%, 30%, 25%, dan 20% untuk kriteria kedisiplinan, kejujuran, kerja sama, dan kualitas kerja, pengelompokan dengan pembobotan kriteria menghasilkan akurasi sebesar 0.8462. Pengelompokan FCM dengan seleksi kriteria menghasilkan kriteria kedisiplinan dan kejujuran merupakan dua kriteria yang penting dalam pengelompokan karyawan, dengan akurasi sebesar 1. Dari hasil perbandingan dua macam pengelompokan tersebut didapatkan bahwa kejujuran merupakan kriteria terpenting dalam pengelompokan karyawan berdasarkan kinerjanya.Kata Kunci: pengelompokan, karyawan, fuzzy c-means, pembobotan kriteria, seleksi kriteria
Biofilm Detection on Catheter Associated Uropathogenic Bacteriuria among Fistula Patients Attending National Obstetric Fistula Centre Ningi, Bauchi State, Nigeria
Authors: Uzuegbunam Ngozi V. , Umar Faruk A. , Bassey Bassey Enya
Published: May 2021

Background: Biofilm production caused by bacteria plays a vital role in catheter associated urinary tract infection (UTI) or bacteriuria being responsible for persistence and recurrent infection. Biofilms forming bacteria are difficult to eradicate due to antimicrobial resistance to the commonly used antibiotic. Biofilms are currently estimated to be responsible for over 65% of nosocomial infections and 80% of microbial infections. This study aimed to perform biofilm detection on uropathogenic bacterial isolates among fistula patients attending National Obstetric Fistula centre Ningi and investigate the antimicrobial susceptibility pattern.

Methods: A total of 217 strains of significant bacteriuria were isolated from vesico vaginal fistula (VVF) patients. A cross sectional study was conducted at the hospital. The urine samples were collected and cultured on CLED and blood agar media while confirmation was done using their biochemical reaction. The detection of biofilms formation on the isolates was performed using tube adherence and Congo red agar method. Antimicrobial susceptibility testing was carried out by disc diffusion method on Muller Hinton agar.

Results: Out of 217 significant bacteriuria isolated, 38 strains produced biofilms;28 strains tested positive on tube adherence method while 15 strains were positive on Congo red agar method. Bacteria that produced biofim showed multiple drug resistance compared to the platonic bacterial cells. All the biofilm producers showed 100% resistant to septrin, ampiclox, gentamycin and amoxicillin. There was no significant value between tube adherence and Congo red agar method with P value > 0.05.

Conclusion: Biofilm detection should form part of routine testing while antimicrobial susceptibility testing is paramount on better choice of antibiotic therapy for proper management to reduce economic lost, treatment failure and drug resistance.
Research on Nutritional Interventions to Recuperation for the Elite Swimmer in the Period Preparation for Competition of 29th SEA Games at Malaysia in 2017
Authors: Nguyen Thi My Linh , Do Trong Thinh , Le Quy Phuong
Published: May 2021

The purpose of the study was efficiency the interventions nutritional to recovery and the requirements related to the use of food and food ingredients for health stability, promotion efficiency of the competition exercises of swimmer by through the indicators reflect about recovery: Hematocrits, Hemoglobin, Testosterone, Creatinine, Rest lactic acid, Maximal Lactic Acid, Creatinine, Blood Pressure, Weight. The results of the study show that, after 6 weeks of the experimental, the swimmer's health is well maintained, swimmer's fitness strength and ability to adapt to the physical training and the swimmer have won 8 gold medals at the competition at the SEA Games 2017 in Malaysia.
Comprehensive Screening for COVID-19 at St. Petersburg Oncology Centre
Authors: Volkov N. M. , Lebedeva M. S. , Egorenkov V. V. , Moiseenko F. V. , Abduloeva N. Kh. , Bogdanov A. A. , Terterov I. N. , Chernobrivceva V. V. , Valeeva N. E. , Myasnikova E. B. , Navatskaya A. S. , Bogdanov A. A. , Moiseyenko V. M.
Published: May 2021

Background. Clinical reports on the coronavirus disease 2019 (COVID-19) suggest its higher incidence and worse outcomes in cancer patients. Considering a rapid pace of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) pandemic, more data on the risk of contagion and syndrome course is required with this patient group.

Aim. Estimation of the infection rate in cancer patients managed at the Oncology Centre.

Materials and methods. This retrospective study included cancer patients managed at the Oncology Centre between 9 April 2020 and 27 May 2020 and routinely tested for SARS-CoV-2 in polymerase chain reaction (PCR) assays and/or COVID-19 in chest computed tomography (CT).

Results and discussion. A total of 2,628 patients were included in the study, with 119 (4.5 %) confirmed to have COVID-19; 45/119 were PCR-positive, 95/119 had viral pneumonia in CT, 21/119 were positive for both tests. A total of 47.9 % cases were asymptomatic, 11.8 % revealed a mild single-symptom disease. COVID-19 ended in death in 2 (2.5 %) of 80 cases with a known outcome. In PCR results of both patient and staff screening, the virus detection rate was 3.0 % and 2.4 %, respectively (p = 0.33).

Conclusion. A COVID-19 screening revealed no significant difference in the risk of contagion between cancer patients and staff of the Oncology Centre. PCR tests may perform false negative for COVID-19 in cancer patients and should be coupled with CT scanning. The infection is asymptomatic or clinically mild in most other cases.
Submental Myodermal Flap in Buccal Reconstruction after Extended Combined Resection
Authors: Kovalenko N. V. , Nenarokomov A. Yu. , Ivanov A. I. , Tolstopyatov S. Ye. , Zhavoronkova V. V. , Chukhnin A. G. , Speransky D. L. , Deviatchenko T. F.
Published: May 2021

Background. Oral mucosal cancer is the most prevalent squamous cell cancer of head and neck, with 6,723 cases registered in Russia, including 94 per Volgograd Region, in 2018. A high tumour advancement and complex topography of the surgical area result in extensive soft-tissue defects and impaired swallowing, chewing and speech.

Aim. Efficacy assessment of submental myodermal flap application in buccal reconstruction after extended combined oncological resections.

Materials and methods. Submental myodermal flap was used as a buccal reconstruction technique in 112 patients aged 42 to 75 years during 2015–2020. Surgery for primary tumour was performed in 88 cases, and in 24 — for recurrence after radiotherapy or surgical excision.

Results and discussion. A six-year experience of the submental myodermal flap usage in reconstructive surgery allowed evidently wider indications for extensive oral resection combined with extended, also bilateral, lymphadenectomy. Clinical records on the technique application in primary and recurrent cancer are presented.

Conclusion. The submental myodermal flap technique in combination with extended or extended combined surgery for oral mucosal cancer notably increases the tumour resectability at this location and improves function restore in patients. The method widens indications for higher-volume operative aid, considerably reduces postoperative complications and holds a promise to enable more radical surgery. This plastic surgery technique is aesthetic and effectively repairs speech and digestive functions, bringing improvement to the patients’ quality of life and social adaptation.
Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook
Authors: Minyazeva R. K. , Battalova G. Y. , Sakhautdinova I. V. , Gilyazova I. R.
Published: May 2021

Gynaecological malignancy is a major challenge in women’s health worldwide. Cervical cancer (CC) is a particularly common type affecting the female reproductive system through an uncontrolled cell propagation causing cervical tissue injury in women. The advent of new technologies empowers research into the discovery and development of novel markers for early diagnosis, as well as therapy evaluation and monitoring. Despite manifold attempts to unravel the molecular mechanisms of CC, its pathogenesis remains largely unclear. The study of putative CC predictors is key to the invention of effective alleviating treatments. Systems biology enabled with high-throughput methods currently provides routes to tackle this problem. Unlike a traditional approach, it generates a wealth of data on prognostic biomarkers and therapeutic targets in cervical cancer, fuelling the search for novel high-sensitive and specific molecular markers. This approach will help improve the early diagnosis and treatment efficacy at a lower relapse rate. This review presents the currently on-stage and emerging biomarkers in cellular and molecular research into cervical cancer detection and prognosis.
Joint-stock companies in Russia as the most important form of corporate organizations
Authors: Goncharov Vitaly Viktorovich , Afanasev Nurgun V. , Shpinev Iurii S.
Published: May 2021

This article is devoted to the analysis of the concept and legal status of joint-stock companies in the Russian Federation. The authors analyze the dynamics of the development of the institute of joint stock companies in Russia from the moment of its appearance to the present.
BUSINESS COACHING: PENGEMBANGAN USAHA INDUSTRI KECIL MENENGAH DI ERA PANDEMI COVID-19
Authors: Wibowo Hery , Irfan Maulana , Santoso Meilanny Budiarti
Published: May 2021

ABSTRAKPandemi covid-19 secara nyata berdampak terhadap kondisi perekonomian masyarakat khususnya bagi para pelaku usaha kecil dan menengah, sehingga diperlukan upaya untuk mengatasi perubahan yang terjadi agar mereka tidak sampai menghentikan kegiatan usahanya. Dalam hal pengembangan usaha, beberapa metode dapat dipilih untuk meningkatkan kinerja, antara lain dengan melakukan kegiatan pelatihan, konsultasi, mentoring ataupun business coaching. Kegiatan pengabdian pada masyarakat ini dilakukan dengan metode business coaching sebagai salah satu upaya meningkatkan kinerja usaha yang didasarkan atas komunikasi apresiatif bertujuan serta kerjasama dan rasa saling percaya diantara pembimbing (coach) dengan mitra (coachee). Secara umum tahapan yang dilakukan adalah kegiatan eksplorasi, assessment, plan of treatment dan treatment. Proses coacing dilakukan terhadap sejumlah pelaku usaha yang memiliki jenis usaha berbeda dengan lokasi usaha tersebar di beberapa wilayah. Hasil pelaksanaan kegiatan kuliah kerja nyata - pengabdian pada masyarakat (KKN-PPM) Unpad menunjukkan bahwa dengan dilakukannya business coaching telah muncul kesadaran baru tentang kondisi usaha dan wawasan baru tentang beragam alternatif teknik usaha yang dapat dioptimalkan untuk menambah pasar, menyasar pelanggan yang tepat dan meningkatkan penjualan. ABSTRACT The Covid-19 pandemic has an impact on the economic condition of the community, especially for small and medium business actors, so efforts are needed to cope with the changes that have occurred so that they can maintain their business. In terms of business development, several methods can be chosen to improve performance, among others, by conducting training activities, consulting, mentoring or business coaching. This community service activity is carried out using the business coaching method as an effort to improve business performance based on appreciative communication with the aim of cooperation and mutual trust between the coaches and partners (coachee). In general, the stages carried out are exploration, assessment, plan of treatment and treatment activities. The coacing process is carried out on a number of business actors who have different types of business with business locations scattered in several regions. The results of the implementation of real work lecture activities - community service (KKN-PPM) Unpad show that by carrying out business coaching, new awareness has emerged about business conditions and new insights on various alternative business techniques that can be optimized to increases the market, target the right customers and increase sales.
MENUMBUHKAN KESADARAN MASYARAKAT MELALUI SOSIALISASI KEBIASAAN HIDUP BARU DI MASA PANDEMI COVID-19
Authors: Santoso Meilanny Budiarti , Zainudiin Moch , Siti Asiah Dessy Hasanah
Published: May 2021

ABSTRAKPandemi Coronavirus Disease 2019 (COVID-19) masih menjadi ancaman bagi masyarakat dunia termasuk Indonesia. Peningkatan kasus belum memperlihatkan adanya penurunan angka penyebaran virus. Pemerintah dalam menanggapi krisis kesehatan telah melakukan beberapa kebijakan untuk menekan penyebaran infeksi COVID-19. Adaptasi Kebiasaan Baru (AKB) menjadi salah satu kebijakan baru yang dikeluarkan oleh pemerintah dalam merespon situasi pandemi. AKB bertujuan agar masyarakat dapat melaksanakan protokol kesehatan ketika terpaksa beraktivitas di luar rumah dalam masa pandemi COVID-19. Upaya preventif dan promosi ini harus disebarluaskan kepada setiap masyarakat agar semakin banyak masyarakat menjalankan protokol kesehatan. Kegiatan sosialisasi secara daring melalui media sosial menjadi metode yang ditempuh dalam kegiatan pengabdian kepada masyarakat di masa pandemi COVID-19. Tingginya intensitas penggunaan media sosial menjadi media paling efektif dalam penyebaran edukasi mengenai AKB. ABSTRACTPandemic Coronavirus Disease 2019 (COVID-19) is still a threat to the global community, including Indonesia. The increase in cases has not shown a decrease in the spread of the virus. The government in response to the health crisis has implemented several policies to reduce the spread of COVID-19 infection. Adaptasi Kebiasaan Baru (AKB) or adapting to new habits is one of the new policies issued by the government as a response in a pandemic situation. The AKB aims for the public to implement health protocols when they have to do activities outside the home during the COVID-19 pandemic. These preventive and promotional moves should be disseminated to every community so there would be more people who can implement health protocols. Social media is one of the most effective platforms used for this community service program during the COVID-19 pandemic. The high amount of people using social media during this time is the most effective media in disseminating education about AKB.
DAMPAK PANDEMI COVID-19 TERHADAP ANGKA PERCERAIAN
Authors: Ramadhani Salsabila Rizky , Nurwati Nunung
Published: May 2021

ABSTRAKPandemi COVID-19 atau severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) merupakan sebuah permasalahan global yang tidak hanya berdampak pada sektor kesehatan, namun berdampak pula pada sektor perekonomian dan berdampak pada permasalahan kependudukan, salah satunya peningkatan kasus perceraian akibat dari pandemi covid-19. Selama pandemi covid 19, Indonesia mengalami peningkatan kasus perceraian sebesar 5 persen. Tulisan ini merupakan kajian literatur yang bertujuan untuk menganalisis perceraian yang terjadi di masa pandemi COVID-19 dan menghubungkannya dengan teori fungsional struktural. Penulisan artikel ini menggunakan pendekatan studi literatur. Secara umum, faktor penyebab perceraian di masa pandemi ini karena terjadi konflik dan perselisihan dalam rumah tangga yang disebabkan oleh pertengkaran/perselisihan dan permasalahan ekonomi karena banyak pekerja yang di PHK secara mendadak, sehingga keuangan keluarga menjadi tidak stabil. Mayoritas istri mengungkapkan bahwa alasan utama yang melatar belakangi terjadinya perceraian yaitu faktor ekonomi dikarenakan Suami tidak mampu untuk memenuhi seluruh kebutuhan dasar keluarga dikarenakan jumlah pendapatan yang kurang muncukupi. Oleh karena itu, sangat dibutuhkan interaksi dan komunikasi yang baik di tengah persoalan atau konflik yang menimpa pasangan suami istri untuk mencegah terjadinya perceraian serta suami istri harus dalam satu frekuensi saat menyelesaikan masalah supaya tercipta keharmonisan dalam keluarga  ABSTRACTThe COVID-19 pandemic or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global problem that not only affects the health sector, but also affects the economic sector and has an impact on demographic problems, one of which is an increase in divorce cases as a result of the pandemic. covid-19. During the Covid 19 pandemic, Indonesia experienced an increase in divorce cases by 5 percent. This paper is a literature review that aims to analyze divorce that occurred during the COVID-19 pandemic and relate it to structural functional theory. Writing this article using a literature study approach. In general, the causes of divorce during this pandemic are due to conflicts and disputes in the household which are caused by quarrels / disputes and economic problems because many workers are dismissed suddenly, so that family finances are unstable. The majority of wives reveal that the main reason behind the occurrence of divorce is economic factors because the husband is unable to meet all the basic needs of the family due to the insufficient amount of income. Therefore, good interaction and communication is needed in the midst of problems or conflicts that befall a married couple to prevent divorce and husband and wife must be in one frequency when solving problems in order to create harmony in the family
Initial Experience and Results of Combined Treatment for Atrial Fibrillation: Catheter Ablation with High-Power Short Duration Ablation and Left Atrial Appendage Closure
Authors: Vassallo Fabricio , Serpa Eduardo , Walker Betina Reseck , Meigre Lucas Luis , Carloni Hermes , Simões Jr Aloyr , Cunha Christiano , Pezzin Flávia , Loureiro Karla , Amaral Dalton , Lovatto Carlos Alexandre , Batista Jr. Walter Duarte , Serpa Renato
Published: May 2021

Introduction: Long-term freedom from atrial fibrillation (AF) after catheter ablation and, consequently, the potential for stroke reduction remain unpredictable. Recently, left atrial appendage closure (LAAC) became an effective mechanical alternative to oral anticoagulation (OAC) for stroke prevention in AF patients. Objective: This study aims to evaluate the feasibility and safety of combined treatment for AF with catheter ablation (CA) with the high-power short duration technique associated with LAAC in one single procedure. Methods: Patients with non-valvular AF who underwent combined CA and LAAC procedure were included in the retrospective observational study. Between April 2018 and October 2020, 13 patients with AF were included, eight (61,54%) males, eight (61.54%) with persistent AF (PersAF), mean age 68.54 (65–84) years old, mean time from AF diagnosis to treatment 13.08 (3–33) months, mean CHA2VASC2 5.08 (3–7), all patients with coronary or vascular disease, 12 (92.31%) with hypertension, five (38.46%) with left ventricular dysfunction, four (30.77%) prior strokes using OAC and four (30.77%) patients with diabetes. Indications for LAAC included history of contraindication to OAC because of severe bleeding in eight (61.54%), previous stroke in four (30.77%) and two (13.08%) patients with LAA thrombus, despite the use of two different OAC (one associated with bleeding). One patient had a pseudoaneurysm in femoral artery, and two patients died of non-procedure complications after 30 days. At six months, angiotomography showed successful complete sealing of the LAA in seven (77.72%) of nine patients evaluated, and the two patients without it had a leak of less than 2 mm. After mean follow-up of 14 months (five to 33), 10 (90.91%) of the 11 patients were in sinus rhythm. Three (27.27%) patients, one in blanking period, recovered sinus rhythm after amiodarone. No cardioembolic or bleeding events occurred. Conclusion: In this small observational study, we showed the feasibility and safety of the combined therapy with AF catheter ablation with LAAC with a high rate of sinus rhythm and no cardioembolic event.
Cryoablation of a Mahaim Epicardial Accessory Pathway Inside Coronary Sinus Using an 8-mm Catheter
Authors: Valdigem Bruno Pereira , Silva Nilton José Carneiro da , Andalaft Rogerio Braga , Almeida Carla , Araujo Junior Nilson , Scazzuso Fernando , Souza Olga F de
Published: May 2021

Cyoablation is a ablation technique underutilized except in parahissian pathways and atrial fibrillation ablation. Ablation inside venous coronary sinus remains a dreaded incursion, and cryoablation is rarely used. We present the case of a 43 YO female who had a recurrent wolff parkinson white syndrome due to an epicardial pathway inside the coronary sinus successfully treated with a large bore(8mm) cryocatheter. We also review literature and describe the advantages and similar reports of use of cryo in low flow recesses inside the heart.
Nodular lymphocyte-predominant Hodgkin Lymphoma in children. Retrospective clinical and morphological analysis of the patients. One Center experience
Authors: Senchenko M. A. , Abramov D. S. , Nasirdinova G. A. , Volchkov E. V. , Konovalov D. M. , Myakova N. V.
Published: May 2021

Lymphocyte-predominant Hodgkin's lymphoma (NLPHL) is a unique variant of Hodgkin's lymphoma (LH) with a relatively good prognosis. The tumor differs markedly from classic LH and is one of the forms B cell lymphoma. Despite the indolent course, it has a tendency to multiple and often late relapses. Microscopically, the tumor has 6 distinguishable morphological patterns. Despite the prevalence in all age groups, most of the original studies were performed among adult patients, while there are only several publications among the children's population. The aim of this study – retrospective analysis pediatric group of the NLPHL, evaluate the prognostic implication of histopathologic variants. Сomparing our own data with another study groups. This study is supported by the Independent Ethics Committee and approved by the Academic Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. Study was included the biopsies aged 3 to 18 years (median 10.5 years) of 28 patients with NLPHL from the archive by Department of Pathology Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology from 2014 to 2020. The tumor more commonly affects males (20 boys and 8 girls, male-female ratio, 2.5:1). Complete clinical information was available in 24 patients. The clonal molecular assays were performed in 2 cases of relapse/progression of the disease. The Fisher's exact test was used to compare and evaluate the statistical significance of the differences in groups of patterns. There were no significant differences between typical patterns and variants, probably due to the small number of the patients. Further research will create a predictive scale for stratification by the risk groups. In cases of poor response to therapy, there is a risk that the pattern will turn into a prognostically more unfavorable variant.
The results of multicenter treatment of atypical teratoid/rhabdoid tumors of the central nervous system in children under 3 years
Authors: Olkhova L. V. , Zheludkova O. G. , Zubarovskaya L. S. , Smirnova A. Yu. , Dinikina Yu. V. , Kushel Yu. V. , Melikyan A. G. , Gorelyshev S. K. , Ryzhova M. V. , Trunin Yu. Yu. , Shults E. I. , Gevorgyan A. G. , Gorbatykh S. V. , Kislyakov A. N. , Popov V. E. , Privalova L. P. , Yudina N. B. , Tarasova E. M. , Pogorelov D. N. , Polushkina O. B. , Levashov A. S. , Vorobyov N. A. , Plakhotina N. A. , Martynova N. I. , Skvortsova T. Yu. , Zaychikov A. N. , Mushinskaya M. V. , Sakun D. L. , Minkina L. M. , Lukina T. V. , Shchepkina E. V. , Korshunov A. G.
Published: May 2021

Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS) is an aggressive malignant tumor that is mainly found in younger children and is associated with poor prognosis. Our objectives: to present the results of treatment of children with CNS AT/RT under 3 years of age and assess the impact of various prognostic factors on patient survival. The study was approved by the Independent Ethics Committee and the Scientific Council of the N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation. The study included 106 patients with CNS AT/RT aged 0–3 years who had been treated and monitored from 2008 to 2020. The median age was 16 (9; 23) months. All the patients underwent primary tumor resection with subsequent chemotherapy according to various protocols. At the time of the analysis, 47 patients (44.4%) were alive, 1 patient (0.9%) was lost to follow-up and 58 patients (54.7%) were dead, of whom 52 patients (90%) had died of disease progression and 6 (10%) – of polychemotherapy complications. One patient developed shunt-related intraabdominal metastasis within 10 months of the diagnosis. The 1-year progression-free survival (PFS) was 0.50; the 2-year PFS was 0.29; the 5-year PFS – 0.27. The median PFS was 12 months. The 1-year overall survival (OS) was 0.72; the 2-year OS was 0.53; the 5-year OS – 0.40. The median OS was 27 months. An analysis of patients with CNS AT/RT under 3 years of age showed that PFS was statistically significantly higher in: children aged > 12 months; children with totally resected tumours; children who had received polychemotherapy in accordance with the ATRT-2006 protocol that included radiotherapy and regional administration of a triplet of chemotherapeutic agents. The OS in patients with CNS AT/RT aged < 3 years was statistically significantly higher in: children aged > 12 months; children who had been treated with radiation therapy; patients who had received cytosar/etoposide intrathecally/intraventricularly; patients who had undergone high-dose chemotherapy with subsequent autologous hematopoietic stem cell transplantation. A multivariate analysis revealed that PFS was influenced by age, tumor location, extent of resection and exposure to radiation therapy, regional chemotherapy or high-dose chemotherapy with autologous hematopoietic stem cell transplantation, while OS was affected by age and exposure to radiation therapy.
BCG vaccine–related complications in patients with primary immunodeficiencies after allogeneic hematopoietic stem cell transplantation
Authors: Machneva E. B. , Mezentseva A. V. , Olkhova L. V. , Pristanskova E. A. , Burya A. E. , Konstantinova V. V. , Filina O. A. , Nikolayeva Yu. A. , Svetacheva A. A. , Blagonravova O. L. , Kirgizov K. I. , Skorobogatova E. V.
Published: May 2021

BCG (Bacillus Calmette–Guérin) vaccine is widely used for the vaccination of newborns within the first few days of life to prevent mycobacterial infections. However, complications occurring after BCG vaccination in patients with primary immunodeficiencies (PIDs) can lead to serious consequences for their health and life. BCG vaccine-related complications occurring in patients with severe combined immunodeficiency (SCID) and chronic granulomatous disease (CGD) after hematopoietic stem cell transplantation (HSCT) constitute an important problem. The article presents a retrospective observational analysis of 45 patients with SCID and CGD who received BCG vaccination and underwent HSCT. In the post-transplant period, 33 (73.3%) patients had BCG-related complications, either localized or generalized. The presence of BCG vaccine-related complications in the pre-transplant period was a significant predictor of the development of post-transplant complications. The most severe and long-term BCG vaccine-related complications were observed in the patients with SCID: the median time to the resolution of symptoms of BCG infection was 30 days and 100 days in the CGD patients and the SCID patients, respectively (p< 0.001). The severity of BCG vaccine-related complications, the nature of the primary disease and the presence of pre-transplant BCG vaccine-related complications did not affect the overall survival (OS) of the patients: OS for the entire study group was 79.5 ± 6.6%. Non-compliance with antimycobacterial prophylaxis prior to HSCT resulted in severe infections in a number of patients. The treatment of BCG vaccine-related complications included a combination of several antimycobacterial agents, and anti-inflammatory drugs (such as glucocorticoids, interleukin-1 and 6 receptor antagonists) in cases of immune reconstitution inflammatory syndrome (n= 18). The only effective method of prophylaxis of BCG-related infections in patients with SCID and CGD in the pre- and post-transplant period is the exemption of newborns from BCG vaccination based on their family history. Uninterrupted antimycobacterial prophylaxis in vaccinated patients in the pre- and post-transplant period is also important. Furthermore, an effective uniform strategy for the prevention and treatment of BCG vaccine-related complications in PID patients both before and after HSCT is needed.
CNS relapse of B-lymphoblastic lymphoma after allogeneic hematopoietic stem cell transplantation: therapy with donor CD19-specific CAR-T cells
Authors: Molostova O. O. , Shelikhova L. N. , Pershin D. E. , Popov A. M. , Dubrovina M. E. , Klimentova M. A. , Maschan A. A. , Maschan M. A.
Published: May 2021

Presently, there is no consensus on the best treatment for relapsed B-cell acute lymphoblastic leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in patients with extramedullary lesions. There are certain anti-tumor drugs that can be used in case of relapse after allo-HSCT, however, prospective randomized studies directly comparing different chemotherapy and immunotherapy approaches are generally lacking. Retrospective studies exploring therapy for relapsed disease are difficult to compare due to the inhomogeneity of patient populations and the diversity of treatment approaches. In such situations, the treatment choice is influenced by the characteristics of the tumor population, particularly, its immunophenotype, available drugs, and the experience of a healthcare facility and physicians. This clinical case report describes the process of treating a patient with B-lymphoblastic lymphoma and shows the possibility of using donor CD19-specific CAR-T cells as a treatment for isolated CNS relapse after allo-HSCT. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.
Treosulfan-based conditioning for hematopoietic stem cell transplantation in patients with Diamond–Blackfan anemia
Authors: Radygina S. A. , Kozlovskaya S. N. , Vasilieva A. P. , Shipitsina I. P. , Bogoyavlenskaya А. А. , Ovsyannikova G. S. , Shelikhova L. N. , Skvortsova Yu. V. , Balashov D. N. , Maschan M. A.
Published: May 2021

Busulfan-based conditioning regimens before hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia (DBA) are the standard therapy for a long time. Unfortunately, the high incidence of toxic complications is the cause of transplant-related mortality (TRM) or low quality of life. Treosulfan-based conditioning is very attractive, however only limited data exists of its administration in DBA patients. In this article, we present the experience of treosulfan usage along with novel approaches to “graft versus host” disease (GVHD) prophylaxis in Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. From 2012 to 2020, 9 patients with DBA underwent HSCT. Matched unrelated donors were used in 7 patients, mismatched related in 1, and HLA-identical sibling in 1 patient. All patients received treosulfan-based conditioning. The sources of HSC were bone marrow (n = 3) and peripheral blood after TCRab+/CD19+ graft depletion (n = 6). Eight patients received various regimens of post-transplant prophylaxis, included calcineurin inhibitors alone or in combinations, 1 patient – mycophenolate mofetil. All transplanted patients engrafted. Median follow-up in survivors (n = 8) was 35.6 months. One patient (Karnofsky-index before HSCT 40%) died on day +58 due to multio rgan failure, caused by toxic and infectious complications. Besides, three patients had clinically signifiant toxic complications: oral mucositis grade 3 in 1 patient, treosulfan skin toxicity in 2, and moderate veno-occlusive-disease in 1 patient. Five patients had acute GVHD grade II with complete response to the 1st line therapy. There was no evidence of acute GVHD grade III–IV as well as chronic GVHD. Our data demonstrate, that treosulfan-based conditioning, alongside new cellular engineering approaches is effctive options for HSCT outcomes in patients with DBA.
An Irrigation Homogenity Assessment of a Variable Rate Sprinkler Irrigation
Authors: Szabó Andrea , Tamás János , Nagy Attila
Published: May 2021

Nowadays, the development of irrigation is increasingly recognized as a necessary factor in agriculture, primarily because of global warming. Depending on the field conditions, the most commonly used method is sprinkler irrigation. The spray uniformity of sprinklers installed on the field irrigation equipment can be characterized by the Christiansen-uniformity coefficient (CUc%) and the distribution uniformity coefficient (DU%). Our investigations were carried out on the lateral moving irrigation equipment of University of Debrecen, Institutes for Agricultural Research and Educational Farm and Nyírbátor’s company in Hungary in 2019. Variable rate irrigation (VRI) is used in Nyírbátor. In contrast, the VRI has given positive results, making an irrigation equipment with the VRI a safer and more uniform method than a conventional linear irrigation equipment.
Energy-saving design of office buildings considering light environment and thermal environment
Authors: Ding N. , Guo H.
Published: May 2021

The energy consumption of office buildings is analysed, and the influential factors to be considered in architectural design that affect the light and heat environment of office buildings are summarised. The original building model was established by Ecotect, and variable methods were adopted to simulate the influence of different influencing factors on the light and thermal environment, and to quantitatively evaluate the importance of different factors on energy consumption of buildings. This analysis provides an important basis for optimised energy saving design, and finally puts forward the optimal design strategy for energy saving, so as to build harmonious light and heat architectural environment.
An empirical investigation of physical literacy-based adolescent health promotion
Authors: Du Minmin , Liu Yimin , Li Lei
Published: May 2021

A reexamination of the health problems of Chinese adolescents based on the concept of physical literacy (PL) was necessary. Through the use of follow-up data collected from the China Education Panel Survey 2014–2015, the main factors affecting the health of adolescents were identified, and possible explanations were investigated after cluster and inductive analyses were conducted. The results showed that (1) the 10 main factors identified as affecting adolescent health promotion are in line with the four main elements of PL (emotional, cognitive, social and physical elements) and (2) the three major categories of influencing factors identified through a cluster analysis were aligned with the three main factors of PL (endogeneity, fundamentality and permeability). These findings suggest that the factors influencing adolescent health promotion are closely associated with PL. The study results can provide empirical evidence for adolescent health promotion research and a reference for the development of evidence-based PL training models.
The Pearson Bayes factor: An analytic formula for computing evidential value from minimal summary statistics
Authors: Faulkenberry Thomas J.
Published: May 2021

In Bayesian hypothesis testing, evidence for a statistical model is quantified by the Bayes factor, which represents the relative likelihood of observed data under that model compared to another competing model. In general, computing Bayes factors is difficult, as computing the marginal likelihood of data under a given model requires integrating over a prior distribution of model parameters. In this paper, I capitalize on a particular choice of prior distribution that allows the Bayes factor to be expressed without integral representation, and I develop a simple formula – the Pearson Bayes factor – that requires only minimal summary statistics as commonly reported in scientific papers, such as the t or F score and the degrees of freedom. In addition to presenting this new result, I provide several examples of its use and report a simulation study validating its performance. Importantly, the Pearson Bayes factor gives applied researchers the ability to compute exact Bayes factors from minimal summary data, and thus easily assess the evidential value of any data for which these summary statistics are provided, even when the original data is not available.
التنظيم القانوني لشركة المحاماة المدنية المهنية (دراسة تحليلية مقارنة)
Authors: M. Younis Hadi , Kh. Salih Nashwan
Published: May 2021

ظهرت الحاجة الى الشركات المدنية المهنية لممارسة مهنة المحاماة نظرا لأهمية هذه الشركات، فمن يمارس المهنة من المحامين منفرداً لا يتمكن –في غالب الاحوال- من انجاز خدمة العميل بالسرعة المطلوبة، اضافة الى ان العميل الذى يتعامل مع شركة المحامين المدنية يجد نفسه امام فريق من المهنين المتخصصين على مستوىً من القدرة في الانجاز غير ضئيل، وعلى مستوىً من الكفاءة يمكنه من التصدي  للمشكلات التي تعترضه هذا من جانب، ومن جانب اخر ان ممارسة مهنة المحاماة من خلال شركة مدنية مهنية تتيح فرصة التخصص، فالتطور المتلاحق للعلوم، جعل المهني الواحد لا يمكّنه الالمام بشتى تفاصيل المهنة، فالمحامي لا يستطيع ان يحيط علماً بجميع فروع القانون المختلفة، امام هذا التعقيد، لا بد للمهنيين من التخصص والحل الامثل يكمن في تكوين شركات مدنية مهنية يضم شركاء كل واحد يتخصص في فرع من فروع القانون المختلفة اذ بإمكانهم تداول الافكار وضم خبراتهم والوصول الى نتائج مرضية. هذا وقد اكتسبت هذا الموضوع بعداً اخر بعد صدور قانون التعديل الثالث رقم 8 لسنة 2018  لقانون المحاماة لإقليم كوردستان رقم 17 لسنة 1999 المعدل. ونعالج هذا الموضوع من خلال مبحثين  نتناول في اولهما التعريف بشركة المحاماة المدنية ونخصص ثانيهما لأركان عقد شركة المحاماة المدنية المهنية.
Diagnósticos diferenciais das deficiências cognitivas em idosos
Authors: Silva Bruna de Sousa , Zanetti Isabella dos Santos , Barros Patrícia Peres de , Souza Letícia Ton de , Barreto Leonardo Brandão
Published: May 2021

Objetivo: Realizar uma revisão bibliográfica a fim de identificar as possíveis etiologias das deficiências cognitivas em idosos e seus diagnósticos diferenciais. Revisão bibliográfica: A demência é caracterizada por comprometimento gradual da função cognitiva que interfere nas atividades sociais e profissionais, uma vez que, os indivíduos apresentam uma maior propensão ao desenvolvimento de incapacidades funcionais, podendo ser causa importante de redução na qualidade de vida dos idosos e de seus familiares. O estudo revela a existência de uma grande variedade de etiologias das deficiências cognitivas em idosos, sendo classificadas em demências degenerativas e demências não degenerativas. As demências degenerativas (ou primárias) incluem a doença de Alzheimer, a demência por corpos de Lewy e a demência frontotemporal, dentre outras. As demências não degenerativas (ou secundárias) abrangem inúmeros subtipos dentre os quais a demência vascular, deficiência de vitaminas, depressão e insuficiência renal. Considerações finais: As deficiências cognitivas representam um grande problema de saúde pública, com consequências significativas para os idosos e seus familiares. Diante da grande variedade de etiologias das deficiências cognitivas é fundamental o conhecimento de seus diagnósticos diferenciais.