bluuebunny/crossref_metadata_2025 huggingface dataset:
EPIDEMIOLOGIA DA VIOLÊNCIA INFANTIL UM ESTADO DO NORDESTE DO BRASIL: SÉRIE HISTÓRICA DE 2007 A 2016
Authors: Almeida Luiz Antonio dos Anjos , Sousa Luciana Sena , Sousa Karinna Alves Amorim de
Published: December 2017

Objetivo: analisar o perfil, e descrever as características de crianças de 0 a 14 anos, que foram notificadas com violência infantil de 2007 a 2016 em um estado do nordeste do Brasil. Método: estudo descritivo, epidemiológico, realizado por meio de levantamento na base de dados SINAN-NET. Os dados foram coletados em outubro de 2015 e são referentes aos anos de 2007 a 2016. Resultados: Os dados de 6037 registros foram levantados e analisados revelando que as vítimas mais frequentes foram as crianças do sexo feminino, com idade  de 10 a 14 anos, parda, residentes na zona urbana, Sobre os tipos de violência, destaca-se a a prevalência da violência sexual com 92% dos casos, física com 51,7%, e a psicológica com 73,14%. Conclusão: o perfil da Violência em crianças residentes no Estado experimenta um considerável aumento do número de casos notificados ao longo dos anos. Características regionais  como prevalência do sexo feminino, faixa etária mais acometida, residentes em zona urbana, cor da pele parda, acometidas principalmente por violência sexual se fazem presentes.
PENGARUH GAYA KEPEMIMPINAN KEPALA SEKOLAH DAN MOTIVASI KERJA GURU TERHADAP KINERJA GURU SMP SE-KECAMATAN KERSANA KABUPATEN BREBES
Authors: Zamroni Mohamad , Nurkolis Nurkolis , Yuliejantiningsih Yovitha
Published: December 2017

Penelitian ini bertujuan untuk: (1) mengetahui pengaruh gaya kepemimpinan kepala sekolah terhadap kinerja guru, (2) pengaruh motivasi kerja terhadap kinerja guru, dan (3) pengaruh gaya kepemimpinan kepala sekolah dan motivasi kerja guru secara simultan terhadap kinerja guru SMP.Jenis penelitian adalah penelitian kuantitatif populasi adalah guru SMP di Kecamatan Kersana Kabupaten brebes sebanyak 130. Sampel penelitian ini sejumlah 98 orang guru. Data dikumpulkan melalui angket. Uji validitas, Reliabilitas, Normalitas data, linearitas dan Uji hipotesisi melalui regresi linier sederhana dan regresi linier ganda menggunakan SPSS 21.Hasil analisis regresi menunjukkan bahwa: (1) pengaruh gaya kepemimpinan kepala sekolah (X1) terhadap kinerja guru (Y) sebesar 15,7%, (2) pengaruh motivasi kerja (X2) dengan kinerja guru (Y) signifikan karena hasil analisis statistik menunjukkan F hitung lebih besar dari F tabel yaitu F hitung 11,781>F tabel (0,5598) = 2,30 dengan signifikan 0,000<0,05. Berdasarkan data statistik tersebut ada korelasi antara motvasi kerja guru terhadap kinerja guru sebesar 10,9%, dan (3) pengaruh gaya kepemimpinan kepala sekolah (X1) dan motivasi kerja (X2) bersama-sama secara positif dan signifikan gaya kepemimpinan kepala sekolah, motivasi kerja guru terhadap kinerja guru berdasarkan data statistik berpengaruh sebesar 21,6%.Ssaran yang diberikan (1) gaya kepemimpinan kepala sekolah yang belum baik selama ini perlu ditingkatkan untuk meningkatkan kualitas kinerja guru, (2) perlu meningkatkan motivasi kerja para guru untuk meningkatkan kinerjanya,
Apresentação
Authors: Pereira Caetano Antonio Filipe
Published: December 2017

Editorial Nº 2, Ano I, Dezembro/2010.
Centenário da Revolução Mexicana (1910-2010) Entrevista – General Emiliano Zapata Salazar para o Diário “Nova Era”
Authors: Flores Alberto Vivar
Published: December 2017

Unimo-nos solidariamente ao povo mexicano na celebração do Centenário da Revolução Mexicana (1910–2010), publicando o fac-símile de uma entrevista realizada pelo jornalista Armando Vasquez Contreras, ao General Emiliano Zapata Salazar para o Diario “Nova Era”, na cidade de Anenecuilco, em 1911. Essa entrevista se deu no contexto da insatisfação zapatista com os rumos que ia tomando a revolução liderada naquele momento por Francisco I Madero. E, como conseqüência da elaboração do “Plan de Ayala”, em 28 de Novembro do mesmo ano.Observa-se no texto a simplicidade da linguagem usada pelo camponês General Zapata e, ao mesmo tempo, a firmeza, o vigor, a sinceridade e a convicção dos ideais revolucionários. Tais características, uma vez concluída a luta armada, o tornaram ícone das revoluções agrárias no mundo.
Nos Limites da Criminalidade: Práticas de homicídios, conflitos e relações de sociabilidade em Salvador (1940-1960)
Authors: B. de Souza Wanderson
Published: December 2017

Discutiremos aqui aspectos da criminalidade em Salvador, a partir da análise das práticas de homicídios, na tentativa de compreender as relações conflituosas dos grupos marginalizados em suas multiplicidades de formas e configurações históricas. Percebemos como algumas dessas situações, aparentemente banais, resultavam em violentos conflitos pessoais que eram resolvidos longe do alcance dos poderes públicos. Para realização deste trabalho, buscamos estabelecer um cruzamento entre as fontes jornalísticas, processos criminais e um conjunto de correspondências trocadas entre as autoridades policiais. Nossos esforços foram no sentido de perceber de que forma o diálogo entre as referidas fontes ajudaram a entender essas querelas que expressavam as dinâmicas sociais estabelecidas nas relações cotidianas dessas pessoas entre os anos de 1940 e 1960.
Aproximações a Ginzburg: Comentários sobre Relações de Força
Authors: Batista Acioly Maciel Osvaldo
Published: December 2017

GINZBURG, Carlo. Olhos de madeira: nove reflexões sobre a distância. Tradução de Eduardo Brandão – São Paulo: Cia. das Letras, 2001.GINZBURG, Carlo. Relações de força: história, retórica, prova. Tradução de Jonatas Batista Neto – São Paulo: Cia. das Letras, 2002.GINZBURG, Carlo. Latitude, Slaves, and the Bible: an experiment in Microhistory. In: www.helsinki.fi/collegium/events/-urry.pdf – capturado em 09 de agosto de 2006.
O Professor Aureliano da Fonseca – Breve nota biográfica
Authors: Pesquisa-Guimarães José
Published: December 2017

Homenagem ao Professor Aureliano da Fonseca – XV Congresso Nacional de Dermatologia e Venereologia, 6 de Novembro de 2015, Porto
Omalizumab no Tratamento do Penfigóide Bolhoso - O Estado da Arte
Authors: Mendes-Bastos Pedro , Cunha Daniela , Cardoso Jorge
Published: December 2017

Introdução: Assistiu-se recentemente a um avanço significativo no conhecimento da fisiopatologia do penfigóide bolhoso, tendo sido demonstrado o papel patogénico dos auto-anticorpos anti-BP180 do subtipo IgE. O presente trabalho pretende explicitar os mecanismos patogénicos dos auto-anticorpos IgE no penfigóide bolhoso e discutir os dados publicados relativos à utilização clínica de omalizumab no seu tratamento.Material e Métodos: Revisão de artigos em revistas com indexação na Medline/PubMed usando como termos de pesquisa “omalizumab bullous pemphigoid”.Resultados: São revistas e discutidas 9 publicações, bem como como artigos relacionados, quando considerado pertinente. Na maioria dos casos, o omalizumab revelou-se um fármaco eficaz em seguro, sendo utilizado mais frequentemente como adjuvante a outras terapêuticas imunossupressoras. O papel de biomarcadores como IgE total ou contagem de eosinófilos na seleção de doentes ou monitorização do tratamento é ainda desconhecido.Conclusões: A utilização de omalizumab no tratamento do penfigóide bolhoso é sustentada pela patogenicidade conhecida dos auto-anticorpos IgE específicos. A experiência clínica publicada é escassa, apontando o omalizumab como uma opção segura e eficaz no penfigóide bolhoso resistente à corticoterapia/imunossupressão. Por não condicionar imunossupressão, poderá constituir uma opção valiosa no tratamento do penfigóide bolhoso. São necessários estudos prospetivos aleatorizados, particularmente se comparativos com prednisolona oral em monoterapia.
Furúnculo Causado por CA-MRSA - Relato de Caso
Authors: Carneiro de Castro Carlos Gustavo , De Toledo Leme Maia Camille Maximiliana , Bialowas Daniel , De Sá Guedes Fábio , De Castro Peixoto Carvalho Laila , Abreu Pereira Azis Livia , Tinoco Plata Glaura
Published: December 2017

Nas últimas décadas, o desenvolvimento da resistência bacteriana aos diversos beta-lactâmicos relacionada a alterações codificadas pelo gene mecA, tem causado um aumento da incidência de infecção por Staphylococcus aureus meticilina-resistente adquirido na comunidade, antes apenas documentado em ambientes nosocomiais. Relatamos o caso de um paciente com furúnculos recorrentes que após realização de cultura e antibiograma evidenciou trata-se de infecção por community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA). Na ocasião a terapêutica instituída foi baseada no antibiograma havendo regressão total do quadro.
Placa Única no Dorso do Pé em Doente a Trabalhar em País Tropical (Timor-Leste)
Authors: Teixeira Ana Isabel , Borges-Costa João
Published: December 2017

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Análise da Estatística Nosológica Nacional 2009-2013. Grupo Português de Dermatologia Pediátrica
Authors: Osório Ferreira Eduarda
Published: December 2017

O Grupo Português de Dermatologia Pediátrica elaborou uma análise da estatística nosológica nacional no período de 2009 a 2013, baseada nos dados compilados de 12 centros a nível nacional. Foram estudados dados referentes a 22.354 primeiras consultas. Os eczemas foram o grupo de doenças mais frequentemente observado - 5.104 pacientes (22,3%), seguido dos nevos - 4.678 (20,4%), infecções - 4.651 (20,3%), doenças das faneras - 2.770 (12,1%), doenças vasculares - 1.066 (4,7%), e doenças da pigmentação - 1.033 (4,5%). Foi ainda feita uma análise comparativa entre a estatística actual e aquela realizada pelo Grupo há 10 anos. Este tipo de estudos parece-nos importante porque permite conhecer a realidade nacional relativamente à prevalência das doenças cutâneas da infância, eventuais variações ao longo dos anos e estabelecer comparações com estudos realizados noutros países. Finalmente, poderão ajudar a melhorar a medicina preventiva.
Síndrome de Graham-Little-Piccardi-Lasseur: Relato de um caso raro
Authors: Nóbrega Monisa Martins , Siqueira Thais Marques Feitosa Mendes , Ormay Mariana Santiago , Obadia Daniel Lago , Gripp Alexandre Carlos
Published: December 2017

A Síndrome de Graham-Little-Piccardi-Lasseur (SGLPL) caracteriza-se por apresentar, progressivamente: alopecia cicatricial multifocal do couro cabeludo associada a hiperqueratose folicular disseminada e hipotricose não cicatricial axilar e púbica. Os achados clínicos da síndrome podem estar presentes simultaneamente, embora a alopecia do couro cabeludo muitas vezes preceda os outros achados em meses a anos.Acomete principalmente mulheres na idade adulta, sendo considerada uma doença muito rara. A terapêutica desta dermatose é um desafio sendo muitas medicações relatadas porém com resultados controversos.Relatamos o caso de uma paciente do sexo feminino apresentando área de alopecia na região parietal direita, pápulas violáceas poligonais pruriginosas paravertebrais, máculas hipercrômicas com rendilhado branco na mucosa oral além de discreta diminuição dos pelos axilares. Após uso de anti-histamínicos e aplicação tópica e intralesional de corticoides na placa alopécica observamos discreta melhora e a paciente permanece em acompanhamento.
Vitamina D – Perspetivas Atuais
Authors: Miroux Catarino Alexandre , Claro Cristina , Viana Isabel
Published: December 2017

A vitamina D tem como efeito biológico principal a promoção da mineralização óssea e a regulação da homeostasia do metabolismo cálcio-fósforo. A sua função biológica extra-esqueleto tem sido amplamente estudada e o seu défice associado a risco aumentado para diversas patologias, nomeadamente autoimunes, neoplásicas, cardiovasculares e neurológicas, entre outras. No entanto, esta mantém-se uma área de controvérsia e está por demonstrar a relação causa-efeito entre deficiência de vitamina D e patologia não esquelética, e o benefício da suplementação com esse objetivo. Nos indivíduos em risco de hipovitaminose a suplementação é segura, barata e com benefício demonstrado na prevenção de fraturas e quedas. É feita uma abordagem da síntese, metabolismo e modo de ação da vitamina D. Faz-se uma revisão sumária da fisiopatologia da vitamina D na pele - a influência da pigmentação cutânea e do uso de fotoproteção na sua síntese, e a sua relação com as dermatoses mais frequentes.
ESPOROTRICOSE NA INFÂNCIA: MIMETIZANDO LEISHIMANIOSE COM EVOLUÇÃO FAVORÁVEL AO IODETO DE POTÁSSIO.
Authors: MACHADO THALITA MARÇAL , DANTAS CAMILA ARAÚJO , PROHMAN CAROLINE MEDEIROS , E SILVA LORENA BARCELOS , MONTES LORENA FERREIRA , GATTI RAFAEL FIGUEIREDO , POZETTI EURIDES MARIA DE OLIVEIRA
Published: December 2017

A esporotricose é uma infecção crônica da pele e do tecido celular subcutâneo, causada pelo fungo Sporothrix schenkii. Na infância esta entidade é rara, embora atualmente a maior ocorrência nessa faixa etária seja pela transmissão zoonótica. O atraso no diagnóstico e o uso inadvertido de múltiplos esquemas antimicrobianos levam à progressão da doença, causando dor e, posteriormente, cicatrizes inestéticas. O diagnóstico diferencial principal em formas cutâneas e linfocutânea é a leishmaniose. Embora haja recomendações internacionais para o itraconazol como primeira linha de tratamento, este tem nível de evidência igual à solução saturada de iodeto de potássio e a apresentação líquida da solução é mais fácil de ser administrada e aceita pelas crianças.
Pioderma gangrenoso associado com hemoglobinúria paroxística noturna.
Authors: RONALDO FRANCISCO RONALDO MOURA
Published: December 2017

O pioderma gangrenoso é uma dermatose neutrofílica crônica sem etiologia estabelecida. Sabe-se que ele é associado a doenças sistêmicas, como hemoglobinúria paroxística noturna, diabetes, doença de Crohn, colagenoses, entre outras. Manifesta-se através de lesões cutâneas ulceradas e dolorosas com evolução rápida e progressiva, sendo mais comum em membros inferiores. As ulcerações podem surgir espontaneamente ou após vários tipos de trauma. O período entre o início das lesões e o diagnóstico correto costuma ser prolongado.  O diagnóstico geralmente é baseado em evidências clínicas e confirmado com a exclusão das outras etiologias de lesões ulceradas cutâneas. Relatamos um caso de pioderma gangrenoso em membro superior esquerdo com início após evento traumático em paciente com diagnóstico de hemoglobinúria paroxística noturna.
Pápula única no pénis
Authors: Marcos-Pinto Ana , Borges-Costa João , Soares-de-Almeida Luís
Published: December 2017

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Dermatite Infeciosa Associada a Infeção por HTLV-1 no Adulto: Difícil Diagnóstico e Importante Manejo Clínico
Authors: Silva Correia Priscila , Cabral Fernanda , Higino de Souza Gabriela , Barrella Neto Miguel , Lago Abadia Daniel , Brum Cursi Igor
Published: December 2017

A dermatite infeciosa é uma dermatite grave, crónica e recidivante associada ao vírus linfotrópico de células T humano tipo 1 (HTLV-1). Embora a maioria dos casos descritos tenha início na infância, casos de dermatite infeciosa em adultos tem sido relatados. O quadro dermatológico mimetiza condições comuns como dermatite seborreica, dermatite atópica, dermatite de contato, impetigo e micose fungóide. Em países endémicos para a infeção por HTLV-1, como o Brasil, é imprescindível que a dermatite infeciosa seja lembrada como diagnóstico diferencial nestes casos. A identificação precoce é importante a fim de evitar a disseminação e proporcionar acompanhamento e tratamento adequados de possíveis complicações associadas ao vírus, como a mielopatia associada ao HTLV ou paraparesia espástica tropical, e a leucemia/linfoma de células T do adulto. Relatamos o caso de dois pacientes do sexo feminino com dermatite infeciosa de início na idade adulta. Para enriquecimento do caso, também apresentamos as fotos da filha de uma das pacientes, com mesmo diagnóstico.
Pápula Única no Pénis
Authors: Marcos-Pinto Ana , Soares-de-Almeida Luís , Borges-Costa João
Published: December 2017

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O Tamanho dos Ninhos Expansivos Juncionais pode Predizer o Comportamento dos Melanomas in situ
Authors: Pantaleão Luciana , Esmeraldo Silva Licínio , Carrijo Rochael Mayra
Published: December 2017

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PARACOCCIDIOIDOMICOSE COM ACOMETIMENTO LINFONODAL E MUCOSO – RELATO DE CASO
Authors: Prohmann Caroline Medeiros
Published: December 2017

A Paracoccidioidomicose (também conhecida como Doença de Lutz, Doença de Lutz-Splendore-Almeida, Blastomicose Brasileira ou  Blastomicose Sul Americana) foi inicialmente descrita por Lutz há quase um século. Trata-se de uma infecção fúngica sistêmica, que pode apresentar-se sob duas formas clínicas: aguda/subaguda ou crônica.            As lesões orais da paracoccidioidomicose são tipicamente caracterizadas por hiperplasia gengival eritematosa e finamente granular, com petéquias. Além disso, observam-se úlceras rasas com microgranulações e pontilhados hemorrágicos, que podem acometer lábios, mucosa jugal, palato, pilares amigdalianos e língua. As lesões apresentam superfície semelhante à amora denominadas, assim, de “estomatite moriforme”. Apesar de comuns, essas lesões são subdiagnosticadas e o reconhecimento tardio desta patologia pode levar à rápida progressão do quadro clínico, às vezes resultando em óbito.            Relatamos o caso de um paciente jovem apresentando linfadenopatia generalizada, estomatite moriforme e sintomas constitucionais. Destaca-se a importância do dermatologista na identificação precoce das lesões cutâneo-mucosas típicas da paracoccidioidomicose e no estabelecimento de um diagnóstico preciso.
Disfunção Tiroideia: Uma Nova Associação com a Psoríase?
Authors: Borges A. S. , Brasileiro A.
Published: December 2017

A psoríase é uma dermatose inflamatória crónica frequente com elevado impacto na qualidade de vida dos doentes. Diversos fatores exógenos e endógenos têm sido implicados na sua etiopatogénese, nomeadamente determinados distúrbios endócrinos. Estudos prévios têm demonstrado que as hormonas tiroideias podem estar implicadas na fisiopatologia da psoríase. Neste artigo será feita uma revisão do papel das hormonas tiroideias na psoríase assim como da evidência científica atual sobre uma possível associação entre psoríase e disfunção tiroideia.
Lobomicose
Authors: Moura Filho Francisco Ronaldo , Guimarães Grana Aline , Kenhinde Sobreira Fernandes de Macedo Gabriel , Lima Tupinambá Walquiria , Reyes Romero Sandra Adolfina , Bandeira de Melo Patricia Chicre
Published: December 2017

Lobomicose ou doença de Jorge Lobo é uma infecção crónica e granulomatosa causada pela implantação traumática do fungo Lacazia loboi. Esta doença acomete pele e tecido celular subcutâneo. Trata-se de uma dermatose infecciosa típica de regiões tropicais e subtropicais que acomete frequentemente homens adultos ativos nas áreas florestais, além de ter sido diagnosticada em golfinhos. No geral afecta áreas expostas da pele, tais como o pavilhão auricular, os membros superiores e inferiores. Lesões queiloidiformes constituem a manifestação clínica mais comum. A remoção cirúrgica é o procedimento terapêutico de escolha nos casos iniciais, enquanto itraconazol e clofazimina, isolados ou em associação, podem ser utilizados nos casos disseminados.
Blended Learning Voice: Students’ Perceptions Of Mid Transitioning Into Digital Needs Of Academic Reading
Authors: Friatin Lilies Youlia , Rachmawati Etika , Ratnawati Ratnawati
Published: December 2017

Blended learning is one of the e- learnings to be concerned its improvement and it can not be apart from the digital learning practices. Moreover, the application of blended learning itself is such of educational innovation in the 21st century era not only in Indonesian setting but also in the worldwide spread. In fact, the deployement of blended learning which is covered by e-learning in Indonesia is not good enough in higher education setting. The present study investigated students’ perception of applying it in an academic reading class as  part of demand in digital era. The descriptive study was employed to analyze the students’ questionnaire toward the application of blended learning during classroom practices with the 30 participants took part in the research. The students’ positive responses and interpretation from students revealed of implementation of it though some troubles occured during teaching and learning process. From the result of the data, it indicates that blended learning can be one of the educators’ choices of classroom practices in order to improve the quality of higher education and it provides  innovation of education in digital era. The study  provides the limitations and pedagogical suggetions.
Relationship between Morphology and Trophic Ecology in an Assemblage of Passerine Birds in Riparian Forests of the Paraná River (Argentina)
Authors: Quiroga Virginia , Lorenzón Rodrigo E. , Maglier Gisela , Ronchi-Virgolini Ana L.
Published: December 2017

We describe the ecomorphology of an assemblage of bird species found in riparian forests of the Middle Paraná River, Argentina. We sought to determine (1) the more important morphological characteristics that separate coexisting species, (2) whether such separation was related to the trophic ecology of each species and (3) whether a priori guilds showed morphological similarity. We tested the hypotheses that (a) a species’ morphology is related to the trophic ecology of that species and (b) that species of a priori guilds are morphometrically more similar to each other than to species of different a priori guilds. For this, we considered an assemblage of 29 species of birds from riparian forest that were sampled with mist nets during the 2011 and 2014 breeding seasons. We obtained morphometric measurements of captured individuals and supplemented those data with measurements from museum specimens. Trophic characterisation (diet and trophic microhabitat) was based on a literature review. Results showed a separation of bird species as a function of variables related to trophic ecology (diets and trophic microhabitats) and morphology. After controlling for phylogenetic constraint, species’ morphology partially reflected the trophic ecology of the species, supporting the central hypothesis of the ecomorphological discipline and showing that the use of trophic and morphometric data provides complementary data to improve the guild organisation of riparian bird assemblages.
Ranking of Dry Ports in Europe - Benchmarking
Authors: Oláh Judit , Nestler Steffen , Nobel Thomas , Popp József
Published: December 2017

Deutsche GVZ-Gesellschaft (DGG) establishes the first ranking of Freight Villages (dry ports) throughout Europe. The study assesses the level of development of the European Freight Villages by a method oriented on the benchmarking approach. The results of this process build the first ranking of Freight Villages (FV) on an European level. The study will help to provide more transparency to the market segment of international logistics centres and is oriented to give a positive impulse to the further successful European development of sustainable macrologistics concepts. As a kind of a side effect this comparison shall also allow a networking among the FV’s Europe-wide, supported by better knowledge and access to significant information of the market position and strategies of the individual locations.
Public Initiatives of Settlement Transformation: A Theoretical-Methodological Approach to Selecting Tools of Multi-Criteria Decision Analysis
Authors: Guarini Maria Rosaria , Battisti Fabrizio , Chiovitti Anthea
Published: December 2017

In Europe, the operating context in which initiatives of settlement transformation are currently initiated is characterized by a complex, elaborate combination of technical, regulatory and governance-related factors. A similar set of considerations makes it necessary to address the complex decision-making problems to be resolved through multidisciplinary, comparative approaches designed to rationalize the process and treat the elements to be considered in systematic fashion with respect to the range of alternatives available as solutions. Within a context defined in this manner, decision-making processes must often be used to obtain multidisciplinary and multidimensional analyses to support the choices made by the decision-makers. Such analyses are carried out using multi-criteria tools designed to arrive at syntheses of the numerous forms of input data needed to describe decision-making problems of similar complexity, so that one or more outcomes of the synthesis make possible informed, well thought-out, strategic decisions. The technical literature on the topic proposes numerous tools of multi-criteria analysis for application in different decision-making contexts. Still, no specific contributions have been drawn up to date on the approach to take in selecting the tool best suited to providing adequate responses to the queries of evaluation that arise most frequently in the various fields of application, and especially in the settlement sector. The objective of this paper is to propose, by formulating a taxonomy of the endogenous and exogenous variables of tools of multi-criteria analysis, a methodology capable of selecting the tool best suited to the queries of evaluation which arise regarding the chief categories of decision-making problems, and particularly in the settlement sector.
Rate-Distortion Region of a Gray–Wyner Model with Side Information
Authors: Benammar Meryem , Zaidi Abdellatif
Published: December 2017

In this work, we establish a full single-letter characterization of the rate-distortion region of an instance of the Gray–Wyner model with side information at the decoders. Specifically, in this model, an encoder observes a pair of memoryless, arbitrarily correlated, sources

(

S
1
n

,

S
2
n

)

and communicates with two receivers over an error-free rate-limited link of capacity

R
0

, as well as error-free rate-limited individual links of capacities

R
1

to the first receiver and

R
2

to the second receiver. Both receivers reproduce the source component

S
2
n

losslessly; and Receiver 1 also reproduces the source component

S
1
n

lossily, to within some prescribed fidelity level

D
1

. In addition, Receiver 1 and Receiver 2 are equipped, respectively, with memoryless side information sequences

Y
1
n

and

Y
2
n

. Important in this setup, the side information sequences are arbitrarily correlated among them, and with the source pair

(

S
1
n

,

S
2
n

)

; and are not assumed to exhibit any particular ordering. Furthermore, by specializing the main result to two Heegard–Berger models with successive refinement and scalable coding, we shed light on the roles of the common and private descriptions that the encoder should produce and the role of each of the common and private links. We develop intuitions by analyzing the developed single-letter rate-distortion regions of these models, and discuss some insightful binary examples.
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
Authors: Lim Chu , Mathuru Ajay
Published: December 2017

Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer’s disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease.
Automatic Detection and Distinction of Retinal Vessel Bifurcations and Crossings in Colour Fundus Photography
Authors: Pratt Harry , Williams Bryan , Ku Jae , Vas Charles , McCann Emma , Al-Bander Baidaa , Zhao Yitian , Coenen Frans , Zheng Yalin
Published: December 2017

The analysis of retinal blood vessels present in fundus images, and the addressing of problems such as blood clot location, is important to undertake accurate and appropriate treatment of the vessels. Such tasks are hampered by the challenge of accurately tracing back problems along vessels to their source. This is due to the unresolved issue of distinguishing automatically between vessel bifurcations and vessel crossings in colour fundus photographs. In this paper, we present a new technique for addressing this problem using a convolutional neural network approach to firstly locate vessel bifurcations and crossings and then to classifying them as either bifurcations or crossings. Our method achieves high accuracies for junction detection and classification on the DRIVE dataset and we show further validation on an unseen dataset from which no data has been used for training. Combined with work in automated segmentation, this method has the potential to facilitate: reconstruction of vessel topography, classification of veins and arteries and automated localisation of blood clots and other disease symptoms leading to improved management of eye disease.
Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency
Authors: Aires Virginie , Delmas Dominique , Djouadi Fatima , Bastin Jean , Cherkaoui-Malki Mustapha , Latruffe Norbert
Published: December 2017

Carnitine palmitoyltransferase-2 (CPT2) is a mitochondrial enzyme involved in long-chain fatty acid entry into mitochondria for their β-oxidation and energy production. Two phenotypes are associated with the extremely reduced CPT2 activity in genetically deficient patients: neonatal lethality or, in milder forms, myopathy. Resveratrol (RSV) is a phytophenol produced by grape plant in response to biotic or abiotic stresses that displays anti-oxidant properties, in particular through AP-1, NFκB, STAT-3, and COX pathways. Some beneficiary effects of RSV are due to its modulation of microRNA (miRNA) expression. RSV can enhance residual CPT2 activities in human fibroblasts derived from CPT2-deficient patients and restores normal fatty acid oxidation rates likely through stimulation of mitochondrial biogenesis. Here, we report changes in miRNA expression linked to CPT2-deficiency, and we identify miRNAs whose expression changed following RSV treatment of control or CPT2-deficient fibroblasts isolated from patients. Our findings suggest that RSV consumption might exert beneficiary effects in patients with CPT2-deficiency.
A New Label-Free Technique for Analysing Evaporation Induced Self-Assembly of Viral Nanoparticles Based on Enhanced Dark-Field Optical Imaging
Authors: Ghaeli Ima , Hosseinidoust Zeinab , Zolfagharnasab Hooshiar , Jorge Monteiro Fernando
Published: December 2017

Nanoparticle self-assembly is a complex phenomenon, the control of which is complicated by the lack of appropriate tools and techniques for monitoring the phenomenon with adequate resolution in real-time. In this work, a label-free technique based on dark-field microscopy was developed to investigate the self-assembly of nanoparticles. A bio-nanoparticle with complex shape (T4 bacteriophage) that self-assembles on glass substrates upon drying was developed. The fluid flow regime during the drying process, as well as the final self-assembled structures, were studied using dark-field microscopy, while phage diffusion was analysed by tracking of the phage nanoparticles in the bulk solutions. The concentrations of T4 phage nanoparticles and salt ions were identified as the main parameters influencing the fluid flow, particle motion and, consequently, the resulting self-assembled structure. This work demonstrates the utility of enhanced dark-field microscopy as a label-free technique for the observation of drying-induced self-assembly of bacteriophage T4. This technique provides the ability to track the nano-sized particles in different matrices and serves as a strong tool for monitoring self-assembled structures and bottom-up assembly of nano-sized building blocks in real-time.
Photo Processing for Biomedical Hydrogels Design and Functionality: A Review
Authors: Yao Hongyi , Wang Jieqiong , Mi Shengli
Published: December 2017

A large number of opportunities for biomedical hydrogel design and functionality through photo-processing have stretched the limits of innovation. As both photochemical understanding and engineering technologies continue to develop, more complicated geometries and spatiotemporal manipulations can be realized through photo-exposure, producing multifunctional hydrogels with specific chemical, biological and physical characteristics for the achievement of biomedical goals. This report describes the role that light has recently played in the synthesis and functionalization of biomedical hydrogels and primarily the design of photoresponsive hydrogels via different chemical reactions (photo crosslinking and photo degradation) and conventional light curing processes (micropatterning, stereolithography and two/multiphoton techniques) as well as typical biomedical applications of the hydrogels (cell culture, differentiation and in vivo vascularization) and their promising future.
Value of Clean Water Resources: Estimating the Water Quality Improvement in Metro Manila, Philippines
Authors: Jalilov Shokhrukh-Mirzo
Published: December 2017

While having many positive impacts, a tremendous economic performance and rapid industrial expansion over the last decades in the Philippines has had negative effects that have resulted in unfavorable hydrological and ecological changes in most urban river systems and has created environmental problems. Usually, these effects would not be part of a systematic assessment of urban water benefits. To address the issue, this study investigates the relationship between poor water quality and resident’s willingness to pay (WTP) for improved water quality in Metro Manila. By employing a contingent valuation method (CVM), this paper estimates the benefits of the provision of clean water quality (swimmable and fishable) in waterbodies of Metro Manila for its residents. Face-to-face interviews were completed with 240 randomly selected residents. Residents expressed a mean WTP of PHP102.44 (USD2.03) for a swimmable water quality (good quality) and a mean WTP of PHP102.39 (USD2.03) for fishable water quality (moderate quality). The aggregation of this mean willingness-to-pay value amounted to annual economic benefits from PHP9443 billion to PHP9447 billion (approx. USD190 million) per year for all taxpayers in Metro Manila. As expected, these estimates could inform local decision-makers about the benefits of future policy interventions aimed at improving the quality of waterbodies in Metro Manila.
Remote Sensing Image Classification Based on Stacked Denoising Autoencoder
Authors: Liang Peng , Shi Wenzhong , Zhang Xiaokang
Published: December 2017

Focused on the issue that conventional remote sensing image classification methods have run into the bottlenecks in accuracy, a new remote sensing image classification method inspired by deep learning is proposed, which is based on Stacked Denoising Autoencoder. First, the deep network model is built through the stacked layers of Denoising Autoencoder. Then, with noised input, the unsupervised Greedy layer-wise training algorithm is used to train each layer in turn for more robust expressing, characteristics are obtained in supervised learning by Back Propagation (BP) neural network, and the whole network is optimized by error back propagation. Finally, Gaofen-1 satellite (GF-1) remote sensing data are used for evaluation, and the total accuracy and kappa accuracy reach 95.7% and 0.955, respectively, which are higher than that of the Support Vector Machine and Back Propagation neural network. The experiment results show that the proposed method can effectively improve the accuracy of remote sensing image classification.
The Reality of Encounters with Local Life in Other Cultures
Authors: Kim Jin-Young
Published: December 2017

Equipped with mobile technologies, travelers increasingly seek opportunities to encounter the real lives of the people residing in the focal destination. With this trend of pursuing local life experience, this study investigated how international visitors recognize the lives of people in the focal destination, and whether this recognition is related to satisfaction. Reviews for Teheran’s Grand Bazaar from an online review site, Tripadvisor, showed that visitors’ local encounters were linked with favorable emotions (good, interesting, and worthwhile). To lend support to the contact hypothesis, which posits that intercultural experiences can lead to more favorable evaluations of the host community; the visitors who recognized direct and indirect encounters with local life indicated higher satisfaction. Even if brief, the experience of local life appeared to create more intimate feelings for the focal destination. Interestingly, the number of past travel experiences, which was captured by the number of reviews written by the reviewer, was found to have a negative association with satisfaction. We draw further implications for the travelers as well as the local community.
The Development of Assistive Systems to Support Older People: Issues that Affect Success in Practice
Authors: Hallewell Haslwanter Jean , Fitzpatrick Geraldine
Published: December 2017

Due to an aging population in Europe, the development of Ambient Assisted Living technologies (AAL) is increasingly the target of research financing. These technologies promise to enable older people to remain in their own homes longer, something many people report wanting and which may also reduce the costs of care. To date however there are few systems on the market. Other studies have tried to understand this by looking at user acceptance. However, by looking only at the user acceptance, we may miss important aspects to explain why systems went wrong in the first place, since decisions made during the development may affect the success later. To address this, we report on a study in which we applied qualitative methods, including workshops and an interactive poster, to consult with people who have experience in the development of these technologies. We present the common issues reported across various AAL development projects done in Europe that the participants thought were important to the success or failure of projects. We also describe some ideas from participants for addressing some of these problems. The results demonstrate the importance of issues related to financing with grants for projects but also the need for improved user-centered practice.
According to the Plan: Testing the Influence of Housing Plan Quality on Low-Income Housing Production
Authors: Ramsey-Musolf Darrel
Published: December 2017

For more than 20 years, scholars have assessed a plan’s content to determine the plan’s quality, with quality serving as a proxy for planning efficacy. However, scholars rarely examine the relationship between a plan’s quality and the plan’s intended outcome. Thus, it is unclear whether quality influences planning outcomes or even advances equity. To close this gap, this study assessed a non-random sample of housing plans from 43 cities in California’s Los Angeles and Sacramento regions to observe how cities accommodated low-income housing needs and to observe whether each plan’s quality influenced low-income housing production. The analysis indicates that the plans identified 42 different planning tools to accommodate low-income housing needs, and nearly 60% of the implementing objectives proposed construction programs. Quality is influential after the city’s location, land-use, population, and the plan’s compliance with state housing law are taken into account. In summary, quality illuminated how these cities accommodated low-income housing needs and, in conjunction with other city conditions, quality influences low-income housing production. Due to this non-random sample, this study calls on planning scholars to subject quality to more empirical tests on planning outcomes in other areas to increase quality’s importance in scholarship.
Using Herbarium‐Derived DNAs to Assemble a Large‐Scale DNA Barcode Library for the Vascular Plants of Canada
Authors: Kuzmina Maria L. , Braukmann Thomas W. A. , Fazekas Aron J. , Graham Sean W. , Dewaard Stephanie L. , Rodrigues Anuar , Bennett Bruce A. , Dickinson Timothy A. , Saarela Jeffery M. , Catling Paul M. , Newmaster Steven G. , Percy Diana M. , Fenneman Erin , Lauron‐Moreau Aurélien , Ford Bruce , Gillespie Lynn , Subramanyam Ragupathy , Whitton Jeannette , Jennings Linda , Metsger Deborah , Warne Connor P. , Brown Allison , Sears Elizabeth , Dewaard Jeremy R. , Zakharov Evgeny V. , Hebert Paul D. N.
Published: December 2017

Premise of the study: Constructing complete, accurate plant DNA barcode reference libraries can be logistically challenging for large‐scale floras. Here we demonstrate the promise and challenges of using herbarium collections for building a DNA barcode reference library for the vascular plant flora of Canada.

Methods: Our study examined 20,816 specimens representing 5076 of 5190 vascular plant species in Canada (98%). For 98% of the specimens, at least one of the DNA barcode regions was recovered from the plastid loci rbcL and matK and from the nuclear ITS2 region. We used beta regression to quantify the effects of age, type of preservation, and taxonomic affiliation (family) on DNA sequence recovery.

Results: Specimen age and method of preservation had significant effects on sequence recovery for all markers, but influenced some families more (e.g., Boraginaceae) than others (e.g., Asteraceae).

Discussion: Our DNA barcode library represents an unparalleled resource for metagenomic and ecological genetic research working on temperate and arctic biomes. An observed decline in sequence recovery with specimen age may be associated with poor primer matches, intragenomic variation (for ITS2), or inhibitory secondary compounds in some taxa.
Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion
Authors: Huhmann Susanne , Stegemann Anne-Katrin , Folmert Kristin , Klemczak Damian , Moschner Johann , Kube Michelle , Koksch Beate
Published: December 2017

Rapid digestion by proteases limits the application of peptides as therapeutics. One strategy to increase the proteolytic stability of peptides is the modification with fluorinated amino acids. This study presents a systematic investigation of the effects of fluorinated leucine and isoleucine derivatives on the proteolytic stability of a peptide that was designed to comprise substrate specificities of different proteases. Therefore, leucine, isoleucine, and their side-chain fluorinated variants were site-specifically incorporated at different positions of this peptide resulting in a library of 13 distinct peptides. The stability of these peptides towards proteolysis by α-chymotrypsin, pepsin, proteinase K, and elastase was studied, and this process was followed by an FL-RP-HPLC assay in combination with mass spectrometry. In a few cases, we observed an exceptional increase in proteolytic stability upon introduction of the fluorine substituents. The opposite phenomenon was observed in other cases, and this may be explained by specific interactions of fluorinated residues with the respective enzyme binding sites. Noteworthy is that 5,5,5-trifluoroisoleucine is able to significantly protect peptides from proteolysis by all enzymes included in this study when positioned N-terminal to the cleavage site. These results provide valuable information for the application of fluorinated amino acids in the design of proteolytically stable peptide-based pharmaceuticals.
How Many Kilonovae Can Be Found in Past, Present, and Future Survey Data Sets?
Authors: Scolnic D. , Kessler R. , Brout D. , Cowperthwaite P. S. , Soares-Santos M. , Annis J. , Herner K. , Chen H.-Y. , Sako M. , Doctor Z. , Butler R. E. , Palmese A. , Diehl H. T. , Frieman J. , Holz D. E. , Berger E. , Chornock R. , Villar V. A. , Nicholl M. , Biswas R. , Hounsell R. , Foley R. J. , Metzger J. , Rest A. , García-Bellido J. , Möller A. , Nugent P. , Abbott T. M. C. , Abdalla F. B. , Allam S. , Bechtol K. , Benoit-Lévy A. , Bertin E. , Brooks D. , Buckley-Geer E. , Rosell A. Carnero , Kind M. Carrasco , Carretero J. , Castander F. J. , Cunha C. E. , D’Andrea C. B. , Costa L. N. da , Davis C. , Doel P. , Drlica-Wagner A. , Eifler T. F. , Flaugher B. , Fosalba P. , Gaztanaga E. , Gerdes D. W. , Gruen D. , Gruendl R. A. , Gschwend J. , Gutierrez G. , Hartley W. G. , Honscheid K. , James D. J. , Johnson M. W. G. , Johnson M. D. , Krause E. , Kuehn K. , Kuhlmann S. , Lahav O. , Li T. S. , Lima M. , Maia M. A. G. , March M. , Marshall J. L. , Menanteau F. , Miquel R. , Neilsen E. , Plazas A. A. , Sanchez E. , Scarpine V. , Schubnell M. , Sevilla-Noarbe I. , Smith M. , Smith R. C. , Sobreira F. , Suchyta E. , Swanson M. E. C. , Tarle G. , Thomas R. C. , Tucker D. L. , Walker A. R. ,   (DES Collaboration)
Published: December 2017

The discovery of a kilonova (KN) associated with the Advanced LIGO (aLIGO)/Virgo event GW170817 opens up new avenues of multi-messenger astrophysics. Here, using realistic simulations, we provide estimates of the number of KNe that could be found in data from past, present, and future surveys without a gravitational-wave trigger. For the simulation, we construct a spectral time-series model based on the DES-GW multi-band light curve from the single known KN event, and we use an average of BNS rates from past studies of

, consistent with the one event found so far. Examining past and current data sets from transient surveys, the number of KNe we expect to find for ASAS-SN, SDSS, PS1, SNLS, DES, and SMT is between 0 and 0.3. We predict the number of detections per future survey to be 8.3 from ATLAS, 10.6 from ZTF, 5.5/69 from LSST (the Deep Drilling/Wide Fast Deep), and 16.0 from WFIRST. The maximum redshift of KNe discovered for each survey is

for WFIRST,

for LSST, and

for ZTF and ATLAS. This maximum redshift for WFIRST is well beyond the sensitivity of aLIGO and some future GW missions. For the LSST survey, we also provide contamination estimates from Type Ia and core-collapse supernovae: after light curve and template-matching requirements, we estimate a background of just two events. More broadly, we stress that future transient surveys should consider how to optimize their search strategies to improve their detection efficiency and to consider similar analyses for GW follow-up programs.
Le mécénat culturel d’entreprise dans la France des années 1980-1990 : une affaire d’État
Authors: Rozier Sabine
Published: December 2017

Le mécénat est souvent associé à l’expression du libre choix d’individus mettant une partie de leur fortune au service des arts et de la culture. L’article analyse les conditions ayant favorisé des alliances entre de grandes entreprises et des acteurs artistiques et culturels dans la France des années 1980-1990, et montre que ce « mécénat » a surtout été conçu comme un apport complémentaire aux crédits publics. Il souligne le rôle décisif joué par l’administration culturelle étatique française, qui a ardemment travaillé à enrôler les entreprises mécènes au service du financement de ses propres institutions.
Primary extradural paraganglioma of the thoracic spine: A case report
Authors: Reddy Alexander , Morón Fanny
Published: December 2017

Paragangliomas are rare, mostly benign neuroendocrine tumors arising from autonomic paraganglia. Spinal paragangliomas are uncommon, and among these, paragangliomas of the thoracic spine are distinctly unusual.  We present the case of a primary paraganglioma of the extradural thoracic spine in a 34-year-old woman.
Two new Lamiogethes Audisio & Cline from China (Coleoptera: Nitidulidae, Meligethinae)
Authors: Liu Meike , Huang Min , Cline Andrew Richard , Audisio Paolo
Published: December 2017

Two new species of the genus Lamiogethes Audisio & Cline, 2009 are described from China (Sichuan): L. forcipenis sp. n., and L. convexistrigosus sp. n., based on a series of recently collected specimens. The new species are both likely morphologically related to L. potanini (Kirejtshuk, 1979) from Sichuan and to L. conjungens (Grouvelle, 1910) from Yunnan. These new species clearly differ from their related taxa by details of the body shape and color, and the distinct shape of the male and female genitalia. Both new species are likely associated as larvae with a member of the genus Phlomoides Moench (Lamiaceae).