bluuebunny/crossref_metadata_2025 huggingface dataset:
The persuasive effects of scarcity messages on impulsive buying in live-streaming e-commerce: the moderating role of time scarcity
Authors: Hao Shuaikang , Huang Ling
Published: August 2024

Purpose

Live-streaming e-commerce (LSE) allows anchors to bring offline promotion skills to interact with consumers and persuade them to buy. However, how consumers respond to these communications remains unknown. This study examines the persuasive effect of different scarcity marketing messages on impulsive buying in the LSE context.

Design/methodology/approach

This study adopts scenario-based experimental methods and conducts two 2 quantity-based scarcity (supply-framed vs demand-framed)*2 time-based scarcity appeals (high vs low) between-subjects experiments to test the hypotheses.

Findings

The results indicate that supply-framed appeals are more effective in provoking consumers’ arousal and impulsive buying, but are moderated by time scarcity. Furthermore, emotional arousal only mediates the effects of quantity-based scarcity appeals on impulsive buying under high-level time scarcity conditions.

Originality/value

This study contributes to the e-commerce literature by comparing the persuasive effect of different scarcity messages in the LSE context. We broaden the scarcity marketing literature by testing the combined effect of quantity-based and time-based scarcity appeals. Finally, this study extends the application of the competitive arousal model.
The influence of culture, competence, and style of decision-making on the perceived adoption of evidence-based management sources among Polish managers
Authors: Cassar Vincent , Tracz-Krupa Katarzyna , Bezzina Frank
Published: August 2024

Purpose

In this study, we explored factors driving evidence-based management (EBM) decision-making in Poland which has experienced changes from state-controlled market environments to more competitive ones. Evidence-based management requires the critical use and adaptability to information to deal with complex problems.

Design/methodology/approach

In total, 422 Polish managers responded to a telephone survey measuring their perceptions about decision-making culture, styles, competence, and their use of specific sources to derive the evidence to enable them to make evidence-based decisions. Informed by theoretical principles, we used Hayes’ PROCESS macro (Model 4) to examine whether each factor produced direct effects on EBM decision-making and the mediating influence of competence and style in the relationship between culture and perceived evidence-based decision-making.

Findings

All three factors correlated positively with perceived evidence-based decision-making. Moreover, style was not predictive of EBM decision-making compared to competence and culture while culture had an imposing effect on decision-making both as a direct effect and indirectly through competence.

Originality/value

This study provides important insights into the perceptual state of EBM among Polish managers. It emphasizes the importance of embracing diverse cultures and improving critical thinking to help managers make more evidence-based decisions during significant changes in the business world.
Alternative to health consultations or safe spaces? Pregnant women’s health information-seeking behaviour online during the COVID-19 pandemic in Nigeria
Authors: Alade Moyosore , Sanusi Bernice
Published: August 2024

Purpose

The COVID-19 pandemic disrupted healthcare systems globally, including antenatal care coverage. Pregnant women, who were considered “at risk” during the pandemic, replaced in-person antenatal visits with telemedicine and accessed health information online. However, little is known about pregnant women’s online information-seeking behaviour during the COVID-19 pandemic in Nigeria. Hence, the purpose of this paper is to investigate the information seeking behaviour of pregnant women online during the COVID-19 pandemic.

Design/methodology/approach

This research uses qualitative study and in-depth interviews to obtain data from eight pregnant women during the pandemic. Data were thematically analysed, with responses presented verbatim to illustrate themes.

Findings

Findings show that during the COVID-19 pandemic, the unavailability of health professionals and the fear of contracting the COVID-19 virus influenced pregnant women’s information-seeking behaviour online. Pregnant women accessed online sources as alternatives to consultations with health professionals, searched for drug prescriptions and asked pregnancy-related questions online. Findings also revealed that pregnant women conceptualised these online sources and platforms as safe spaces for sharing and dealing with pregnancy-related anxieties and difficulties during the pandemic.

Research limitations/implications

The number of participants sampled in the study is considered satisfactory since data saturation was achieved. However, considering the generalisation and transferability of the research findings, note that the study focused on a limited number of pregnant women in one state in Nigeria (Lagos State). Hence, the design and sample do not provide adequate generalisation to a larger population of pregnant women in Nigeria. Future research may generalise more broadly to other states in Nigeria. Another limitation of the study was using telephone interviews to collect data. Therefore, this paper could not analyse body language and facial expressions, which prevented us from gaining insights into participants’ descriptions of health information-seeking behaviour online. Therefore, further studies should use alternative data collection methods, such as face-to-face or online video interviews, instead of telephone interviews.

Practical implications

This study has implications for health policy interventions. The study’s findings can guide policies on designing digital health systems for pregnant women during health crises.

Originality/value

This study contributes to existing literature on health information-seeking behaviour online among a vulnerable population – pregnant women in a developing country. Specifically, the study contributes to knowledge on how pregnant women’s health information-seeking behaviour can change online within a health-crisis context like the COVID-19 pandemic and its implications for their overall well-being.
Does board gender diversity affect bank financial stability? Evidence from a transitional economy
Authors: Ho Trang N.T. , Nguyen Dat , Le Tu , Nguyen Hang Thanh , Tran Son
Published: August 2024

Purpose

This study aims to investigate whether the changes in gender composition of bank board affects Vietnamese bank stability efficiency.

Design/methodology/approach

This research covers a panel of 27 commercial banks in Vietnam over a 14-year period from 2007 to 2020. The two-step system generalized method of moments is used to estimate the gender diversity–Vietnamese bank stability efficiency nexus.

Findings

The authors find that a greater degree of board gender diversification enhances bank stability efficiency and reduces bank risk-taking in Vietnam. The relationship between gender diversity and the stability efficiency of Vietnamese banks is still valid under the influence of regulatory capital sufficiency and during the financial crisis. These findings are robust to alternative proxies for risk indicators and consistent with the perspectives of stakeholder and behavior theory.

Originality/value

Although this research revisits the relationship between gender diversity and bank risk-taking, it is the first attempt to explore the role of women on board in enhancing the stability efficiency of banks, using the stochastic frontier approach. These findings shed light on the function of gender diversity as a governance instrument for mitigating risk in an emerging market context.
Exploring how institutionalized patriarchy relates to career outcomes among African women: evidence from Nigeria
Authors: Imhanrenialena Benedict Ogbemudia , Ebhotemhen Wilson , Agbaeze Emmanuel Kalu , Eze Nwafor Cletus , Oforkansi Ejike Sebastian
Published: August 2024

Purpose

Following the renewed interest to harness the full potential of African female employees in the workplace, this paper aims to explore how patriarchal behaviors relate to career adaptability, subjective career success and job satisfaction among women in Nigerian organizations.

Design/methodology/approach

A structured questionnaire was used in collecting quantitative data from 508 middle-level managers in Nigerian organizations. The hypotheses were tested with structural equation modeling.

Findings

Patriarchal-induced gendered work practices were found to have a significant negative influence on career adaptability among Nigerian career women. Contrary to expectations, patriarchal discrimination was found to have an insignificant negative influence on job satisfaction and subjective career success, suggesting that Nigerian career women still experience significant subjective career success and job satisfaction amid patriarchal practices in the workplace.

Practical implications

For female employees to possess significant career adaptability resources that will enable them to reconstruct their careers to match redesigned job functions in times of innovation in the workplace, organizations should reinvent their human resources (HR) policies that address patriarchal-induced gendered work practices in the workplace.

Originality/value

This current study extends research on how patriarchy affects female employees in African organizations from the traditional research focus of patriarchy and work-life balance relationships to the under-explored area of career experience among women. To the best of the authors’ knowledge, this is the first quantitative research that explores how patriarchy influences career adaptability resources, subjective career success and job satisfaction among Nigerian female employees.
Mental Health Attitudes and Perspectives of Arab Americans: Exploring Preferred Mental Health Resources, Perceived Barriers to Treatment, and Telemental Health
Authors: Kidess George Ghassan Issa , Browning Liam , Oska Nicole , Hinchey Liza , Saleem Arwa , Knill Sadie , Elhage Malaak , Javanbakht Arash
Published: August 2024

Purpose

Arab Americans experience higher rates of mental illness and lower rates of treatment compared to the general population. While some factors leading to this disparity have been proposed, data in the literature remains lacking. This study aims to explore the mental health perspectives of Arab Americans living in Southeastern Michigan regarding barriers to mental health treatment, treatment resource preferences and telemental health preferences.

Design/methodology/approach

Responses were collected through an anonymous bilingual Qualtrics survey from both Arab and non-Arab participants (n = 294, ages 18+) in Southeastern Michigan. Participants’ perceptions regarding mental health barriers, resource preferences and telemental health were assessed. Comparisons were performed between Arabs and non-Arabs, and among Arabs.

Findings

Compared to non-Arabs, Arabs were less likely to seek mental health treatment from a therapist or a primary care provider and were more likely to not seek treatment. Arabs were more likely than non-Arabs to list fear of being called crazy by others and cultural barriers. With regards to preferences on telemental health utilization, no significant differences between Arab and non-Arab participants were found.

Originality/value

The results provide insights into Arab-American mental health perspectives, especially pertaining to mental health barriers, resources and telemental health preferences, adding a novel perspective on the mental health preferences of Arab-American subgroups, especially regarding gender and age differences. This study highlights the Arab-American population as a nuanced and diverse group, emphasizing the importance of future studies to show a more complete picture of Arab-American mental health.
Life satisfaction, consumption adequacy and social comparison in social deprivation environments
Authors: De Paula Thiago Matheus , Peñaloza Verónica
Published: August 2024

Purpose

This paper aims to evaluate the influence of relative social standing, society’s level of restrictions and consumption adequacy on life satisfaction as well as to examine the moderating effect that an environment of social deprivations can cause in this relationship.

Design/methodology/approach

The analysis uses data from 23,152 individuals distributed in 272 regions of 18 developing countries collected from the World Values Survey (WVS). Given the hierarchical structure nature of the data in a cross-country setting, the paper utilizes a multilevel linear mixed-effects model with cross-level interaction.

Findings

The results show that social deprivation, perception of inadequate consumption and lower social standing negatively affect life satisfaction. Likewise, social comparison and consumption adequacy are moderated by the level of social deprivation, showing that the effect of these variables on life satisfaction is more pronounced for individuals living in regions with a higher level of deprivation than for those living in more affluent societies.

Originality/value

This study enhances the comprehension of well-being within contexts characterized by elevated levels of social deprivation. Furthermore, it provides evidence that objective and subjective deprivations are not independent and antithetical concepts but act mutually in reducing individual well-being.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-08-2023-0623
Do CEOs’ characteristics affect compliance with IFRS 7 risk disclosure requirements?
Authors: Mnif Yosra , Znazen Oumaima
Published: August 2024

Purpose

This paper aims to examine the relationship between CEO’s attributes and the level of compliance with financial instruments risk disclosure (hereafter FIRD) as required by International Financial Reporting Standard (IFRS) 7.

Design/methodology/approach

A data set of financial institutions listed on the Toronto Stock Exchange over the period 2015–2020 has been analyzed. Panel regressions have been estimated to provide empirical support for the testable hypotheses.

Findings

The research findings reveal that chief executive officer (CEO) compensation and financial expertise are positively associated with the level of FIRD provided by Canadian financial institutions. However, the analysis does not document any significant statistical linkage between the compliance score and CEO tenure, gender and age.

Practical implications

This study has important implications for stakeholders evaluating the determinants of reporting quality, for boards of directors considering CEO compensation and expertise and for standard setters considering the compliance level with new standards requirements.

Originality/value

This paper provides novel evidence on the linkage between CEO attributes and corporate disclosure. To the best of the authors’ knowledge, this paper is among the first to explore the impact of CEO characteristics on compliance with International Accounting Standards Board disclosure requirements. The analysis is also among the first to investigate compliance with IFRS 7 before and after the amendments required by IFRS 9.
Integrating the norm activation model and technology acceptance model to explain tourist intention to use public bike rental service
Authors: Nguyen Long Phi , Hoang Dung Phuong , Vu Thong Huy
Published: August 2024

Purpose

Travel destinations worldwide are seeking smart ways to reduce the negative impact of tourism, and the public bike rental service (PBRS) is one of them. To investigate the usage intention of this service among visitors, the author of this research employs an integrated approach consisting of two psychological frameworks: the Norm Activation Model (NAM) and the Technology Acceptance Model (TAM).

Design/methodology/approach

The integrated NAM-TAM model is implemented to conduct a survey (sample n = 777) with visitors to Hanoi, Danang, and Ho Chi Minh City regarding the factors underlying their intentions to continue using the PBRS TNGo.

Findings

Structural equation models suggested that: (1) the NAM-TAM can explain behavioural intention to use a smart PBRS. Perceived Usefulness (PU), Perceived Ease of Use (PE), and Awareness of Consequences (AC) have positive and significant impacts on Attitude Towards Using (AT) and, thus, on Behavioural Intention to Use (BI). Also, Personal Norms (PN) positively influence BI. (2) Among the four independent variables, tourists' AC produces the most potent effect on the intention to continue using a PBRS.

Research limitations/implications

This study can start a new research direction of combining the NAM with other theoretical frameworks to explain customer behaviour in the field of sustainable tourism practices. Future research should explore the proposed model based on comparisons of different tourists’ backgrounds, including nationality, length of stay, spending level, visiting purpose, etc.

Practical implications

This research provides strategic implications for destination management organisations in boosting the use of PBRS amongst tourists, contributing to the environmental sustainability targets of the tourism industry.

Originality/value

This study responds to the existing gap by examining both functional value (indicated by PU and PE) and perceived environmental/social value (proxied by AC) in forming tourists’ attitudes towards PBRS and their usage intention. Our study, therefore, actively contributes to the research stream of tourist behaviour in the field of sustainable tourism practices from the altruistic behavioural perspective.
Knowledge exchanges for collaborative innovation and organizational effectiveness: insights from Indian enterprises
Authors: Naqshbandi M. Muzamil , Oliva Fábio Lotti , Fontana Stefano , Aura Caterina
Published: August 2024

Purpose

This study aims to delve into the relationship between open innovation and organizational effectiveness, expanding upon previous research that primarily focused on the impact of open innovation on firm performance.

Design/methodology/approach

Based on data collected from top- and middle-level managers across diverse sectors in India, the authors examined the intricate dynamics of open innovation and its effects on organizational effectiveness. The authors took two approaches to examine the data; using structural equation modeling and using the fuzzy set qualitative comparative analysis (fsQCA) approach.

Findings

This empirical evidence underscores the potential advantages of adopting open innovation practices within organizations. The contribution extends to both theoretical and practical domains.

Research limitations/implications

Theoretically, this research enriches the literature on open innovation and organizational effectiveness by providing empirical substantiation for their interconnection.

Practical implications

From a practical perspective, the findings offer actionable insights for practitioners and organizational leaders, suggesting that embracing open innovation can significantly enhance organizational effectiveness, ultimately fostering improved performance and competitiveness. The findings also have implications for external stakeholders aiming to engage with innovation-driven organizations for purposes of commercialization and knowledge exchange.

Originality/value

This study advocates for incorporating inbound and outbound open innovation practices within strategic decision-making processes to achieve organizational effectiveness.
Caloric restriction and cafeteria diets alter the nutritional parameters of dams Wistar rats differently during the lactational period
Authors: Rocha-Gomes Arthur , Silva Alexandre Alves da , Riul Tania Regina
Published: August 2024

Purpose

The purpose of this study is to nutritionally evaluate dams exposed to caloric restriction or cafeteria diets during the lactation period.

Design/methodology/approach

Twenty-four female Wistar rats (n = 8/group) and their respective litters received during lactation: Control (CTRL) – received standard chow; Caloric restriction (CR) – received 50% of the ratio of the CTRL group; Cafeteria diet (CAF) – received cafeteria diet. Weighing of the mother rats and their respective litters occurred weekly and the diets were daily. At weaning, levels of glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein (LDL) and triglycerides were evaluated. Abdominal adipose tissue was removed and weighed. Liver tissue was removed to determine the lipid profile.

Findings

CR dams showed lower food (p < 0.01), caloric (p < 0.01) and all macronutrients (p < 0.01) intake. This group also observed intense weight loss (p < 0.01), in addition to low litter weight (p < 0.01). CAF dams had higher caloric intake (p < 0.05) and increased consumption of lipids (p < 0.01). The CAF group also reported greater accumulation of abdominal adipose tissue (p = 0.01), elevated levels of LDL (p < 0.01) and hepatic lipids (p < 0.01), as well as a litter with higher weaning weight (p < 0.01).

Originality/value

Few studies have evaluated the effects of different models of malnutrition focusing on dams. CR dams showed severe weight loss, which may have caused their pups to be underweight. On the other hand, the CAF diet during lactation led to a higher consumption of lipids and accumulation of adipose tissue, which generated a high weight of the litter.
Stock market reaction to mandatory climate change reporting: case of Bursa Malaysia
Authors: Pandey Dharen Kumar , Al-ahdal Waleed M. , Moussa Faten , Hashim Hafiza Aishah
Published: August 2024

Purpose

This study aims to comprehensively understand market reactions to Bursa Malaysia's announcement on mandatory climate-change-related disclosures, exploring sector-specific dynamics and cross-sectional influences.

Design/methodology/approach

The study uses event study methodology on 412 listed firms to analyze market reactions around the announcement date. The sector-wise analysis further delves into variations across industries. Cross-sectional analysis explores the significance of environmental, social and governance (ESG) scores and firm controls in explaining the differences across sample firms.

Findings

The event study reveals initial negative market reactions on the event day, with a subsequent shift from positive to negative cumulative impact, indicating the evolving nature of investor sentiment. The sector-wise analysis highlights heterogeneous effects, emphasizing the need for tailored strategies based on industry-specific characteristics. The cross-sectional findings underscore the growing importance of ESG factors, with firm size and performance influencing market reactions. Financial leverage and liquidity prove insufficient to explain cumulative abnormal return (CAR) differences, while past returns and volatility are influential technical factors.

Practical implications

The economic significance of the results indicates a growing trend where investors prioritize companies with more substantial ESG scores, potentially driving shifts in corporate strategies toward sustainability. Better ESG performance signifies improved risk management and long-term resilience in the face of market dynamics. Regulatory bodies may respond by enhancing ESG reporting requirements, while financial institutions integrate ESG factors into their models, emphasizing the benefits of sustainability and financial performance.

Originality/value

This research contributes to the existing literature by providing a nuanced analysis of market responses to climate-related disclosures, incorporating sector-specific dynamics and cross-sectional influences. The findings offer valuable insights for businesses and policymakers, emphasizing the need for tailored approaches to climate-related disclosure management.
Standard of care and outcomes for Māori patients with neck of femur fractures – an Australia & New Zealand Hip Fracture Registry (ANZHFR) study
Authors: Taylor Grace , Zhu Mark , Cavadino Alana , Mayo Christopher , Young Simon W. , Poutawera Vaughan , Mutu‐Grigg John
Published: August 2024

Background

This study aimed to compare the demographic differences between Māori and NZ Europeans with neck of femur fracture (NOF), identify any differences in management, surgical and post‐op care and outcomes.

Methods

All cases in New Zealand between 2018 and 2020 were collected from the Australia & New Zealand Hip Fracture Registry (ANZHFR). Basic demographics, management factors, and surgical factors were collected. Key outcomes at 120 days post‐fracture included walking status, residential status and survival. Univariate analysis was performed to compare differences in demographics, and management factors between ethnicities. Multivariable analysis was conducted on key outcome comparisons and management differences.

Results

Data from 9432 patients were analyzed. 305 patients were Māori (3.2%). Age‐standardized incidence between Māori and NZ European were similar (103 (95% CI 91–115) vs. 95 (95% CI 92–99)/100 000/year). Māori had a longer time to theatre (38.7 vs. 34.5 h, P = 0.01). The only difference between Māori and NZ European in the key outcomes was private residential status (67% vs. 62% P < 0.01). There was no difference in survival (87% vs. 87% P = 0.68) and decrease in walking status (0.43 vs. 0.41 P = 0.99). Following multivariable analysis, Māori ethnicity was an independent risk factor for time to theatre >48 hours after adjustment for other factors (OR 1.44 (95% CI 1.07, 1.93), P = 0.016).

Discussion

Although Māori were a small percentage of patients with NOFs, there was similar age‐standardized incidence compared to NZ Europeans. While there were no differences in key outcomes, identifying reasons for longer time to theatre for Māori patients is required.
Controlled automated reperfusion of the whole body after cardiac arrest: Device profile of the CARL system
Authors: Gaisendrees Christopher , Vollmer Mattias , Schlachtenberger Georg , Jaeger Deborah , Krasivskyi Ihor , Walter Sebastian , Weber Carolyn , Djordjevic Ilija
Published: August 2024

Background

Cardiac arrest is associated with high mortality rates and severe neurological impairments. One of the underlying mechanisms is global ischemia‐reperfusion injury of the body, particularly the brain. Strategies to mitigate this may thus improve favorable neurological outcomes. The use of extracorporeal cardiopulmonary membrane oxygenation (ECMO) during CA has been shown to improve survival, but available systems are vastly unable to deliver goal‐oriented resuscitation to control patient's individual physical and chemical needs during reperfusion. Recently, controlled automated reperfusion of the whoLe body (CARL), a pulsatile ECMO with arterial blood‐gas analysis, has been introduced to deliver goal‐directed reperfusion therapy during the post‐arrest phase.

Methods

This review focuses on the device profile and use of CARL. Specifically, we reviewed the published literature to summarize data regarding its technical features and potential benefits in ECPR.

Results

Peri‐arrest, mitigating severe IRI with ECMO, might be the next step toward augmenting survival rates and neurological recovery. To this end, CARL is a promising extracorporeal oxygenation device that improves the early reperfusion phase after resuscitation.
CoDesign of a digital intervention for parents with bipolar disorder informed by integrated knowledge translation principles
Authors: Jones Steven H. , Fortier Stephanie , Lodge Christopher , Creswell Cathy , Lobban Fiona , Morriss Richard , Palmier Claus Jasper , Duffy Anne , Green Brian , Wells Abigail , Cryle Lucy
Published: August 2024

Objectives

To provide detailed information on the codesign of a digital intervention to support parents with bipolar disorder (BD) who have young children. Each step of this process is reported, as well as a detailed description of the final version of the intervention in line with the TIDieR framework.

Methods

Clinical experience and lived experience experts participated in online workshops, meetings, and remote feedback requests, informed by Integrated Knowledge Translation (IKT) principles. The IKT research group responded to each phase of recommendations from the knowledge users.

Results

Five clinical experience experts and six lived experience experts engaged with the codesign process. Their recommendations for principles, content, look, and feel, and functionality of the digital intervention were structured over five iterative phases. This led to a final implemented design that was identified by the clinical and lived experience experts (referred to together as the knowledge users group) as genuinely reflecting their input.

Conclusions

The IKT principles offer an accessible structure for engaging with clinical and lived experience experts throughout a codesign process, in this case for a digital intervention for parents with BD. The resulting intervention is described in detail for transparency to aid further evaluation and development and to help other teams planning codesign approaches to intervention development.
Experiences of attending prenatal ultrasounds during the COVID‐19 pandemic in Australia: A cross‐sectional survey
Authors: Nightingale Helen J. , Watts Christina , Pham Kim
Published: August 2024

Background

Prenatal ultrasounds form an important part of routine maternity care in Australia and indeed internationally. The COVID‐19 pandemic necessitated rapid changes in society and healthcare to curb transmission, with evidence demonstrating detrimental impacts on childbearing women associated with these restrictions. However, experiences with pandemic restrictions for prenatal ultrasounds in relation to distress, patient expectations, and satisfaction are largely unknown. This study aimed to explore the experiences of pregnant women attending prenatal ultrasound during the pandemic in Australia.

Methods

A cross‐sectional online survey of people in Australia who had undergone at least one prenatal ultrasound during the period of maternity care restrictions was performed. The survey included validated tools for assessing post‐traumatic stress, satisfaction, and expectations with maternity care.

Results

A total of 1280 responses were obtained. Almost 37% of respondents returned a PCL‐C score consistent with probable post‐traumatic stress disorder. Unexpected ultrasound findings or a high PCL‐C score were more likely to have higher expectations and lower levels of satisfaction with their maternity care experience. Having an ultrasound for pregnancy loss, fetal abnormality, and/or a prior post‐traumatic stress disorder diagnosis were the strongest factors correlating with a high PCL‐C score.

Discussion

The prevalence of post‐traumatic stress symptoms in the study population is concerning and elucidates the distress experienced in association with prenatal ultrasounds during pandemic restrictions in Australia. Maternity services should acknowledge the high levels of service consumers with post‐trauma symptoms and consider trauma‐responsive maternity care adaptations in response to adverse perinatal outcomes for those afflicted with post‐trauma and distress‐related symptoms.
Building a new environmentalism: News media access and framing in Canada's environmental movement
Authors: Graham Nicolas , Robinson Joanna
Published: August 2024

This study provides a content and frame analysis of the news media advocacy of prominent environmental non‐governmental organizations (ENGOs) in Canada. We find that these organizations have an important voice in shaping how climate change is framed in news media, but that ecological modernization frames and narratives, which avoid issues of power, conflict, and social‐transformative change, are dominant. Core elements of this discourse are contested, however, as some ENGOs oppose the fossil sector, critique the shortcomings of proffered (technological) climate solutions, and call for muscular interventions aimed at energy transition. We also find that environmental justice frames – particularly those focused on Indigenous rights – are gaining traction, revealing a promising pathway of influence for ENGOs focused on climate justice.
Digital childhoods and multilingual identities: Preschool children's interactions with a picture book app
Authors: Nilsen Malin
Published: August 2024

This study investigates the application and implications of the use of a multilingual picture book app in Swedish preschools, focusing on children's engagement and educators' roles in supporting multilingual development. Employing semi‐structured interviews and video observations, this study reveals the app's potential in reinforcing multilingual identities, bridging home‐school gaps and fostering peer connections. However, it also uncovers complexities in managing linguistic diversity, reflecting societal language attitudes and hierarchies. Grounded in the sociology of childhood, the study provides a critical lens. This approach seeks to understand how digital reading activities are shaping children's linguistic experiences and identities within a specific social and educational context.
Survival and complication rates of tooth‐ and implant‐supported restorations after an observation period up to 36 years
Authors: Bischof Frank M. , Mathey Ayse A. , Stähli Alexandra , Salvi Giovanni E. , Brägger Urs
Published: August 2024

Background

Tooth‐ and implant‐supported fixed dental prostheses are well‐documented and aesthetic treatment alternatives, and after a comprehensive periodontal treatment, a protocol with a good long‐term prognosis if the maintenance program is strictly followed.

Aim

To reexamine a pre‐existing patient cohort in order to obtain estimated long‐term survival and complication outcomes of fixed dental prostheses.

Materials and Methods

For this study, patients treated with fixed dental prostheses between 1978 and 2002 were reexamined between 2019 and 2020. The restorations were divided in single crowns and fixed dental prostheses supported by teeth (TSC, FPTDP) and implants (ISC, FPIDP). Survival and complication rates were obtained. Kaplan–Meier functions were used to model complication probabilities, and average hazard ratios of different strata were compared using weighted Cox regression.

Results

The mean observation time of 40 patients and 223 reconstructions was 20.3 (±9.7, 1.2–36.2) years. The estimated survival rates were 84% (CI: 77%–92%) for TSC, 63% (CI: 51%–79%) for FPTDP, 87% (CI: 71%–100%) for ISC, and 64% (CI: 34%–100%) for FPIDP after 25 years. Biological complications included carious lesions (10.6%), periodontitis (7.9%), and peri‐implantitis (6.8%). Technical complications included chipping (20.2%) and loss of retention (10.8%).

Conclusion

Biological complications lead to abutment loss in more than two‐thirds of cases, regardless of the type of abutment (tooth or implant). Technical complications are less associated with abutment loss than biological complications.
Association of Patient and Tumor Characteristics With Outcomes in Young Head and Neck Squamous Cell Carcinoma Patients
Authors: Hsieh Ronan W. , Gooding William E. , Nilsen Marci , Kubik Mark , Kelly Zahra , Sridharan Shaum , Skinner Heath , Iheagwara Uzoma , Zevallos Jose P. , Duvvuri Umamaheswar , Kim Seungwon , Ferris Robert L. , Zandberg Dan P.
Published: August 2024

Introduction

We retrospectively studied young patients with head and neck squamous cell carcinoma (HNSCC) to identify factors associated with disease‐specific survival (DSS).

Methods

Patient and tumor characteristics of patients aged ≤45 who received treatments for non‐metastatic HNSCC were collected to identify factors associated with DSS. Proportional hazards regression was applied separately for surgical and non‐surgical patients.

Results

230 patients were included. Surgical and non‐surgical patients had similar DSS. Higher pathologic stages, positive margins, perineural invasion (PNI), extranodal extension and negative HPV status were associated with worse DSS for surgical patients and negative HPV status for non‐surgical patients. In the multivariate analysis, pathologic stages, positive margins, and PNI were associated with worse DSS in surgical patients.

Conclusion

Pathologic stages, positive margins, and PNI are independently associated with worse DSS in young surgical HNSCC patients. PNI is a uniquely strong prognostic factor for young patients.
Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the IGNITE ADOPT PGx investigators
Authors: Skaar Todd C. , Myers Rachel A. , Fillingim Roger B. , Callaghan John T. , Cicali Emily , Eadon Michael T. , Elwood Erica N. , Ginsburg Geoffrey S. , Lynch Sheryl , Nguyen Khoa A. , Obeng Aniwaa Owusu , Park Haesuk , Pratt Victoria M. , Rosenman Marc , Sadeghpour Azita , Shuman Saskia , Singh Rajbir , Tillman Emma M. , Volpi Simona , Wiisanen Kristin , Winterstein Almut G. , Horowitz Carol R. , Voora Deepak , Orlando Lori , Chakraborty Hrishikesh , Van Driest Sara , Peterson Josh F. , Cavallari Larisa A. , Johnson Julie A. , Dexter Paul R. ,   the IGNITE Pragmatic Trials Network
Published: August 2024

Chronic pain is a prevalent condition with enormous economic burden. Opioids such as tramadol, codeine, and hydrocodone are commonly used to treat chronic pain; these drugs are activated to more potent opioid receptor agonists by the hepatic CYP2D6 enzyme. Results from clinical studies and mechanistic understandings suggest that CYP2D6‐guided therapy will improve pain control and reduce adverse drug events. However, CYP2D6 is rarely used in clinical practice due in part to the demand for additional clinical trial evidence. Thus, we designed the ADOPT‐PGx (A Depression and Opioid Pragmatic Trial in Pharmacogenetics) chronic pain study, a multicenter, pragmatic, randomized controlled clinical trial, to assess the effect of CYP2D6 testing on pain management. The study enrolled 1048 participants who are taking or being considered for treatment with CYP2D6‐impacted opioids for their chronic pain. Participants were randomized to receive immediate or delayed (by 6 months) genotyping of CYP2D6 with clinical decision support (CDS). CDS encouraged the providers to follow the CYP2D6‐guided trial recommendations. The primary study outcome is the 3‐month absolute change in the composite pain intensity score assessed using Patient‐Reported Outcomes Measurement Information System (PROMIS) measures. Follow‐up will be completed in July 2024. Herein, we describe the design of this trial along with challenges encountered during enrollment.
Healthcare utilisation and associated costs for methadone versus buprenorphine recipients: Examination of interlinked primary and secondary care electronic health records in England
Authors: Domzaridou Eleni , Allen Thomas , Carr Matthew J. , Millar Tim , Webb Roger T. , Ashcroft Darren M.
Published: August 2024

Introduction

More evidence for patterns of healthcare utilisation and associated costs among people receiving opioid agonist therapy (OAT) is needed. We investigated primary and secondary healthcare usage and costs among methadone and buprenorphine recipients in England.

Methods

We conducted a cohort study using the Clinical Practice Research Datalink GOLD and Aurum databases of patients who were prescribed OAT between 1 January 2007 and 31 July 2019. The cohort was linked to Hospital Episode Statistics admitted patient care, outpatient and emergency department data, neighbourhood‐ and practice‐level Index of Multiple Deprivation quintiles and mortality records. Negative binomial regression models were applied to estimate weighted rate ratios (wRR) of healthcare utilisation. Total and mean costs were calculated using Unit Costs of Health and Social Care and the National Healthcare Service Payment by Results National Tariffs.

Results

Among 12,639 patients observed over 39,016 person‐years, we found higher rate of hospital admissions (wRR 1.18; 1.08–1.28) among methadone compared with buprenorphine recipients. The commonest hospital discharge diagnoses among methadone patients were infectious diseases (19.2%), mental and behavioural disorders (17.0%) and drug‐related poisoning (16.5%); the three commonest among buprenorphine patients were mental and behavioural diseases (21.5%), endocrine (13.8%) and genitourinary system diseases (13.1%). Methadone patients had similar mean costs compared with buprenorphine patients (cost difference: £539.01; 432.11–1006.69).

Discussion and Conclusions

Differences in healthcare utilisation frequency for methadone versus buprenorphine recipients were observed. The differences in associated costs were mainly driven by hospital admissions. These findings offer valuable insights for optimising care strategies and resource allocation for OAT recipients.
Impact of bridging thrombolysis versus endovascular thrombectomy alone on outcomes in anticoagulated patients with atrial fibrillation and acute ischaemic stroke
Authors: Alobaida Muath , Harrison Stephanie L. , Lane Deirdre A. , Rowe Fiona , Austin Philip , Abdul‐Rahim Azmil H. , Lip Gregory Y. H.
Published: August 2024

Background and purpose

The impact of bridging thrombolysis prior to endovascular thrombectomy (EVT) compared to EVT alone on intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH), and death in anticoagulated atrial fibrillation (AF) patients with acute ischaemic stroke (AIS) is not well defined.

Methods

A retrospective study was conducted using data from a federated research network (TriNetX) including 114 health care organisations in the United States. Anticoagulated AF patients with AIS who received either bridging thrombolysis (BT) or EVT alone from September 2018 to November 2023 were included. Following propensity score matching, Cox regression analyses examined the risk of ICH, SAH, and death within 30 and 90 days, comparing anticoagulated AF patients receiving BT versus EVT only.

Results

A total of 3156 patients with AIS were treated with BT or EVT alone. Following 1:1 propensity score matching, the cohort included 766 patients in each group. ICH occurred within 30 and 90 days in 6.9% and 8.0% in the BT group compared with 7.4% and 7.7% in the EVT‐only group (hazard ratios [HR] = 0.92, 95% confidence interval [CI] = 0.63–1.33 and HR = 1.01, 95% CI = 0.71–1.45, respectively). SAH occurred within 30 and 90 days in 4.2% and 4.4% of patients in the BT compared to 3.0% and 3.4% in the EVT‐only group (HR = 1.38, 95% CI = 0.81–2.38 and HR = 1.29, 95% CI = 0.77–2.14, respectively). Death occurred within 30 and 90 days in 17.8% and 19.8% of patients in the BT compared to 22.2% and 27.3% in the EVT‐only group (HR = 0.77, 95% CI = 0.62–0.97 and HR = 0.65, 95% CI = 0.56–0.86, respectively).

Conclusions

In anticoagulated AF patients with AIS, BT was associated with a significantly lower risk of death, with no difference in ICH or SAH risk within 30 and 90 days compared to EVT only.
Presidential Address and record of the Royal Geographical Society (with IBG) AGM 2024
Authors: Clifford Nigel
Published: August 2024

In his final address as President of the Royal Geographical Society (with the Institute of British Geographers), Nigel Clifford reflected on the work of the Society in advancing geographical knowledge and engaging with a strong network of like‐minded organisations in industry, education, government, and the professional sphere. He ended by looking forward to future generations of geographers and how they might be prepared and supported to tackle the planetary problems we face today.
Open strategy and digital transformation: A framework and future research agenda
Authors: Ortner Thomas , Hautz Julia , Stadler Christian , Matzler Kurt
Published: August 2024

Digital technologies increasingly facilitate more transparent information exchange and the inclusion of new and more actors in organizational processes. This resulting ‘openness’ has been studied in multiple domains, including open strategy. Since increased transparency and inclusion are the main dimensions of open strategy, it seems reasonable to assume a theoretical linkage between digital transformation and openness in the strategy process. So far, however, we lack a nuanced understanding about their overlaps and the nature of their interrelationships. In this review, we therefore explore how digital transformation and open strategy interrelate and influence each other and what conditions support or constrain the identified relationships. To do so, we systematically review and synthesize research on open strategy considering the role of digital transformation. We make two contributions: First, we develop a framework mapping out the relationships between digital transformation and open strategy. Our framework shows how open strategy and digital transformation are situated in a dynamic circle of mutual influence. Second, we adopt a strategy‐as‐practice perspective and identify and discuss the roles of agency, power, temporality and materiality. These features can either further support or hamper the identified linkages. Finally, we identify trajectories for future research.
Altered epitopes enhance macrophage‐mediated anti‐tumour immunity to low‐immunogenic tumour mutations
Authors: Yu Qiumin , Zhang Tingran , He Tiandi , Yang Yifan , Zhang Wanli , Kang Yanliang , Wu Zijie , Xie Wenbin , Zheng Jiaxue , Qian Qianqian , Li Guozhi , Zhang Di , Mao Qiuli , Gao Zheng , Wang Xiaoning , Shi Xupeiyao , Huang Shitong , Guo Hanlin , Zhang Haoyu , Chen Lingxiao , Li Ximing , Deng Danni , Zhang Li , Tong Yue , Yao Wenbing , Gao Xiangdong , Tian Hong
Published: August 2024

Personalized neoantigen therapy has shown long‐term and stable efficacy in specific patient populations. However, not all patients have sufficient levels of neoantigens for treatment. Although somatic mutations are commonly found in tumours, a significant portion of these mutations do not trigger an immune response. Patients with low mutation burdens continue to exhibit unresponsiveness to this treatment. We propose a design paradigm for neoantigen vaccines by utilizing the highly immunogenic unnatural amino acid p‐nitrophenylalanine (pNO2Phe) for sequence alteration of somatic mutations that failed to generate neoepitopes. This enhances the immunogenicity of the mutations and transforms it into a suitable candidate for immunotherapy. The nitrated altered epitope vaccines designed according to this paradigm is capable of activating circulating CD8+ T cells and inducing immune cross‐reactivity against autologous mutated epitopes in different MHC backgrounds (H‐2Kb, H‐2Kd, and human HLA‐A02:01), leading to the elimination of tumour cells carrying the mutation. After immunization with the altered epitopes, tumour growth was significantly inhibited. It is noteworthy that nitrated epitopes induce tumour‐infiltrating macrophages to differentiate into the M1 phenotype, surprisingly enhancing the MHC II molecule presenting pathway of macrophages. Nitrated epitope‐treated macrophages have the potential to cross‐activate CD4+ and CD8+ T cells, which may explain why pNO2Phe can enhance the immunogenicity of epitopes. Meanwhile, the immunosuppressive microenvironment of the tumour is altered due to the activation of macrophages. The nitrated neoantigen vaccine strategy enables the design of vaccines targeting non‐immunogenic tumour mutations, expanding the pool of potential peptides for personalized and shared novel antigen therapy. This approach provides treatment opportunities for patients previously ineligible for new antigen vaccine therapy.