bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic Potential of MAGEH1 and Its Correlation with Immune infiltrates in Gastric Cancer
Authors: Li Zitong , Ke Haoran , Deng Wenlin , Li Fang , Wang Siqi , Chen Ye
Published: March 2021

Background: MAGEH1 is a critical gene for regulatory T cell function. However, correlations of MAGEH1 to prognosis and tumor-infiltrating cells in different cancers remain unclear. This study was to determine the prognostic impact of MAGEH1 as well as evaluate MAGEH1 expression and immune infiltrate relevance in gastric cancer.Methods: Oncomine, TIMER2.0, Kaplan-Meier Potter, PrognoScan, Gene Expression Profiling Interactive Analysis (GEPIA), and the Human Protein Atlas database were utilized to analyze the differential MAGEH1 expression and its prognostic value. The relationship between MAGEH1 and gene markers of immune infiltration was confirmed by TIMER2.0 and GEPIA.Results: The prognostic effect of MAGEH1 varied across cancers. Particularly in gastric cancer, highly expressed MAGEH1 showed a significant association with poor prognosis in multiple databases whereas was linked to a better prognosis in patients with adjuvant 5-fluorouracil therapy. MAGEH1 expression positively correlated with infiltrating levels of B cells, CD8+ T cells, CD4+ T cells, neutrophils, macrophages, and dendritic cells in stomach adenocarcinoma (STAD). Furthermore, MAGEH1 expression showed a strong link with markers for monocytes, macrophages, neutrophils and Tregs in STAD tissues.Conclusions: MAGEH1 can serve as a prognostic biomarker in gastric cancer and is related to immune infiltrates.
Research on the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking
Authors: Xinyao Shu , Yunwu Zhang , Yujia Wang , Jing Wu , Xingyu Chen , Ruitong Xu , Xingting Liu , Jingsong Luo
Published: March 2021

Background: To predict the mechanism of Huaijiao Diyu Decoction in the treatment of colorectal cancer. Methods: The active components and related targets of 7 kinds of Chinese medicinal materials were collected from the database of Chinese medicinal materials. CRC related targets are obtained from the Genes card database. cross targets of disease and drug targets were input into the STRING database to construct protein-protein interaction networks.GO enrichment analysis and KEGG enrichment analysis using clusterProfiler packets in the language, Finally, the interaction between core components and core targets is discussed by molecular docking.Result: TCMSP database prompts, There are 34 active compounds mapping 114 targets in Sophora japonica decoction; G enecards database prompts, A total of 858 targets are closely related to CRC, The two data sets map each other to obtain 114 intersection targets. Core components of Sophora flavescens decoction in treating CRC may be quercetin, kaempferol, luteolin, The core therapeutic targets may be PTGS2、PTGS1、HSP90AA1 and AR, CRC related pathways involve multiple molecular functions such as cell proliferation, apoptosis, cell signal transduction, metabolism, endocrine, tumor immunity, transcription and cell metabolism. Molecular docking results show that the binding ability of PTGS1、PTGS2、AR to core components is strong, The Vina value (binding energy) of the interaction between PTGS1 protein and core components is the best, -7.9kcal/mol . Conclusion: This study demonstrates the mechanism of multi-component, multi-target and multi-pathway action in the treatment of CRC, Can provide the idea for clarifying the specific mechanism of Huaijiao Diyu decoction in the treatment of CRC in the future.
Imported Hyalomma Ticks in The Netherlands 2018-2020
Authors: Uiterwijk Mathilde , Ibáñez-Justicia Adolfo , de Vossenberg Bart van , Jacobs Frans , Overgaauw Paul , Nijsse Rolf , Dabekaussen Charlotte , Stroo Arjan , Sprong Hein
Published: March 2021

Background: Ticks of the genus Hyalomma, which are vectors for several tick-borne diseases, are occasionally found in areas outside their endemic range including northern parts of Europe. The objective of this study was to analyse adult Hyalomma ticks that were recently found in The Netherlands. Methods: Hyalomma ticks were morphologically identified. Cluster analysis based upon sequence data (cox1 barcoding) for molecular identification and pathogen detection was performed. Additionally, a cross-sectional survey among horses was conducted to actively search for Hyalomma ticks in summer 2019. Analysis of temperature was done to assess the possibility of i) introduced engorged nymphs moulting to adults and ii) establishment of populations in The Netherlands. Results: Seventeen adult Hyalomma ticks (one in 2018, eleven in 2019, five in 2020) were found by citizens and reported. Fifteen ticks were detected on horses and two on humans. Twelve were identified as H. marginatum, one as H. rufipes and four, of which only photographic images were available, as Hyalomma sp. No Crimean-Congo Hemorrhagic Fever virus or Babesia/Theileria parasites were detected. One adult tick tested positive for Rickettsia aeschlimannii. In the cross-sectional horse survey, no Hyalomma ticks were found. Analysis of temperatures showed that engorged nymphs arriving on migratory birds in spring were able to moult to adults in 2019 and 2020, and that cumulative daily temperatures in The Netherlands were lower than in areas with established H. marginatum populations. Conclusions: Our results show that Hyalomma ticks are regularly introduced in The Netherlands as nymphs and these are able to develop to the adult stage under the Dutch weather conditions. Vigilant citizens can notify Hyalomma adult ticks, especially when attached to horses. Only one human pathogen, Rickettsia aeschlimannii, was found in one of the ticks. The risk of introduction of tick-borne diseases via Hyalomma ticks on migratory birds is considered to be low.
Real-World Comparison of CT-P6 and Reference Trastuzumab for the Treatment of HER2-Positive Early-Stage and Metastatic Breast Cancer
Authors: Bae Soong June , Kim Jee Hung , Ahn Sung Gwe , Jeung Hei-Cheul , Sohn Joohyuk , Kim Gun Min , Kim Min Hwan , Kim Seung Il , Park Seho , Park Hyung Seok , Kim Jee Ye , Jeong Joon
Published: March 2021

Background: Here, we present the first real-world comparison of CT-P6 versus reference trastuzumab (RTZ) for the neoadjuvant treatment of patients with HER2-positive EBC, and for the palliative first-line treatment of patients with HER2-positive metastatic breast cancer (MBC).Methods: We retrospectively identified patients with HER2-positive EBC who had received neoadjuvant treatment with RTZ or CT-P6, plus pertuzumab, carboplatin, and docetaxel, followed by surgery, alongside patients with newly diagnosed HER2-positive MBC who had received palliative treatment with RTZ or CT-P6, plus pertuzumab and docetaxel. The primary endpoints were pathologic complete response (pCR) in the EBC cohort, and progression-free survival (PFS) in the MBC cohort. Results: A similar percentage of patients with EBC achieved a pCR with CT-P6 (74.4% [93/125]) and RTZ (69.8% [90/129]) (p=0.411). For patients with MBC, median PFS did not differ significantly between the two groups (CT-P6: 13.9 months [95% confidence intervals (CIs) not available]; RTZ: 18.4 months [95% CIs 12.5–24.3]; p=0.653). The cardiac safety profiles of CT-P6 and RTZ were similar. Conclusions: These real-world data suggest that CT-P6 has similar effectiveness and cardiac safety to RTZ in patients with HER2-positive EBC and MBC, when administered as part of dual HER2-targeted therapy with pertuzumab plus chemotherapy in the neoadjuvant or palliative setting.
Thermally active nanoparticle clusters enslaved by
engineered domain wall traps
Authors: Tierno Pietro , Johansen Tom , Straube Arthur
Published: March 2021

The stable assembly of fluctuating nanoparticle clusters on a surface represents a technological challenge of widespread
interest for both fundamental and applied research.
Here we demonstrate a technique to stably confine in two dimensions
clusters of interacting nanoparticles via size-tunable, virtual magnetic traps. We use cylindrical Bloch walls arranged to form
a triangular lattice of ferromagnetic domains within an epitaxially grown ferrite garnet film. At each domain, the magnetic stray field generates an effective harmonic potential with a field tunable stiffness. The experiments are combined with theory to show that the magnetic confinement is effectively harmonic and pairwise interactions are of dipolar nature, leading to central, strictly repulsive forces. For clusters of magnetic nanoparticles, the stationary collective states arise from the competition between repulsion, confinement as the tendency to fill the central potential well. Using a numerical simulation model as a quantitative map between the experiment and theory we explore the field-induced crystallization process for larger clusters and unveil the existence of three different dynamical regimes. The present method provides a model platform for investigations of the collective phenomena emerging when strongly confined nanoparticle clusters are forced to move in an idealized, harmonic-like potential.
Decay and renormalization of a longitudinal mode in a quasi-two-dimensional antiferromagnet
Authors: Do Seung-Hwan , Zhang Hao , Williams Travis , Hong Tao , Garlea Vasile , Jang T.-H. , Cheong Sang-Wook , Park Jae-Hoon , Batista Cristian , Christianson Andrew
Published: March 2021

An ongoing challenge in the study of quantum materials, is to reveal and explain collective quantum effects in spin systems where interactions between different modes types are important. Here we approach this problem through a combined experimental and theoretical study of interacting transverse and longitudinal modes in an easy-plane quantum magnet near a continuous quantum phase transition. Our inelastic neutron scattering measurements of Ba2FeSi2O7 reveal the emergence, decay, and renormalization of a longitudinal mode throughout the Brillouin zone. The decay of the longitudinal mode is particularly pronounced at the zone center. To explain these observations, we develop a generalized linear spin-wave theory, including all of the one-loop corrections, which reproduces the measured mode decay and renormalization. The theoretical approach developed here is broadly applicable to quantum magnets with more than one type of low energy mode.
A model for the co-evolution of dynamic social networks and infectious disease dynamics
Authors: Nunner Hendrik , Buskens Vincent , Kretzschmar Mirjam
Published: March 2021

Recent research shows an increasing interest in the interplay of social networks and infectious diseases. Many studies either neglect explicit changes in health behavior or consider networks to be static, despite empirical evidence that people seek to distance themselves from diseases in social networks. We propose an adaptable steppingstone model that integrates theories of social network formation from sociology, risk perception from health psychology, and infectious diseases from epidemiology. We argue that networking behavior in the context of infectious diseases can be described as a trade-off between the benefits, efforts, and potential harm a connection creates. Agent-based simulations using a generic model implementation show that: (i) high (perceived) health risks create strong social distancing, thus resulting in low epidemic sizes, (ii) small changes in health behavior can be decisive for whether the outbreak of a disease turns into an epidemic or not, (iii) high benefits for social connections create more ties per agent, providing large numbers of potential transmission routes and opportunities for the disease to travel faster, and (iv) higher costs of maintaining ties with infected others reduce final size of epidemics only when benefits of indirect ties are relatively low. These findings suggest a complex interplay between social network, health behavior, and infectious disease dynamics. Furthermore, they contribute to solving the issue that neglect of explicit health behavior in models of disease spread may create mismatches between observed transmissibility and epidemic sizes of model predictions.
Osteoporosis Knowledge, Beliefs, and Preventive Behaviors in Postmenopausal Breast Cancer Survivors
Authors: Bailey Stacyann , Lin Jenny
Published: March 2021

BackgroundAromatase inhibitor therapy induces bone loss and risk of fracture in postmenopausal breast cancer survivors (PBCS). Targetable patient-level factors to mitigate osteoporosis risk in this population are underreported. Here, we assessed the association between osteoporosis knowledge and beliefs, receipt of bone mineral density, and osteoporosis preventive behaviors among PBCS. MethodsIn this cross-sectional study, early stage PBCS with diabetes mellitus (ages 55-86 years) completed the Facts on Osteoporosis Quiz, Osteoporosis Health Beliefs Scale, and Osteoporosis Preventive Behaviors cross-sectional questionnaires. Multivariate logistic regression assessed factors associated with engagement in strength-training exercise.ResultsMean age was 66.1 years with 20% self-reporting as non-Hispanic White, 40% non-Hispanic Black, 27% Hispanic, and 13% other. Osteoporosis knowledge (10.5±3.4), seriousness (14.9±3.8), and susceptibility (14.0±3.5) mean scores were low. Most (75%) PBCS were adherent to calcium and vitamin D supplements, but only 47% reported engagement in strength-training exercises. Married/partnered, higher osteoporosis knowledge and health motivation scores were associated with exercise. After adjustment of marital status and osteoporosis knowledge, only health motivation was associated with exercise (OR 5.56, 95% CI 1.35-22.93). ConclusionsPBCS are motivated to keep a healthy lifestyle despite limited osteoporosis knowledge, perceived risk, and susceptibility. However, <50% participated in strength-training exercise. Oncologic care should include osteoporosis and fracture prevention strategies, directed at encouraging cancer survivors to increase engagement in strength-training exercises and calcium intake.
Momentum-resolved electronic band structure and offsets in an epitaxial NbN/GaN superconductor/semiconductor heterojunction
Authors: Yu Tianlun , Wright John , Khalsa Guru , Pamuk Betül , Chang Celesta , Matveyev Yury , Schmitt Thorsten , Feng Donglai , Muller David , Xing Huili , Jena Debdeep , Strocov Vladimir
Published: March 2021

The electronic structure of heterointerfaces play a pivotal role in their device functionality. Recently, highly crystalline ultrathin films of superconducting NbN have been integrated by molecular beam epitaxy with the semiconducting GaN. We use soft X-ray angle-resolved photoelectron spectroscopy to directly measure the momentum-resolved electronic band structures for both NbN and GaN constituents of this Schottky heterointerface, and determine their momentum-dependent interfacial band offset as well as the band-bending profile into GaN. We find, in particular, that the Fermi states in NbN are aligned against the band gap in GaN, which excludes any significant electronic cross-talk of the superconducting states in NbN through the interface to GaN. We support the experimental findings with first-principles calculations for bulk NbN and GaN. The Schottky barrier height obtained from photoemission is corroborated by electronic transport and optical measurements. The momentum-resolved understanding of electronic properties elucidated by the combined materials advances and experimental methods in our work opens up new possibilities in systems where interfacial states play a defining role.
The attainment of herd immunity with a restructured risk of contact infection in compartmental models
Authors: Law Kian Boon , Peariasamy Kalaiarasu M , Ibrahim Hishamshah , Abdullah Noor Hisham
Published: March 2021

Introduction: The risk of contact infection among susceptible individuals in a randomly mixed population can be reduced by the presence of immune individuals and this concept is referred to as herd immunity. Although herd immunity is observed in vaccinated populations for some infectious diseases, it has never been truly attained in compartmental models such as the susceptible-infectious-recovered (SIR) model. This paper introduces a new SIR framework to overcome the limitation of the conventional SIR model in attaining herd immunity.Methods: Two SIR models were newly developed based on the reduced risk of contact infection. The first model A assumes that the risk of contact infection reduces as soon as susceptible individuals are infected and move from class S(t) to I(t), therefore incorporating prevalence of both infectious and susceptible individuals into its force of infection. The second model B assumes the risk of contact infection would reduce after infected individuals have recovered from infection and move from class I(t) to R(t), therefore incorporating the prevalence of infectious and the inverse of prevalence of recovered individuals into its force of infection. Then, numerical simulations were applied to obtain approximate solutions for all three conventional SIR model, new SIR model A and model B for comparison under exact and arbitrary conditions with β = 0.3 and σ = 0.1 to mimic the infection dynamics with basic reproduction ratio (r0) of 3.0 and herd immunity threshold (HIT) of 0.667 (66.7%).Results and discussion: All three models performed likewise at the initial stage of the epidemic. The conventional SIR model simulated the epidemic diminishing when 94.0% of the population had been infected and recovered, way above its HIT. Model A simulated the epidemic waning when 66.7% of the population had been infected and recovered, in line with its HIT. However, the model conceptualized herd immunity incorrectly. Model B simulated the epidemic waning at 75.6%, slightly above its HIT and was more in line with the fundamental of herd immunity. The difference between model A and model B can be attributed to the proportion of infectious individuals, and this would increase in infectious disease with high transmissibility. The threshold theorem derived based on r0 may not be sufficient for optimal control and eradication of infectious disease with high transmissibility like the COVID-19.Conclusion: The newly developed SIR model that includes the inverse of proportion of recovered individuals into its force of infection is more accurate and credible for modelling infection with high transmissibility or vaccine-induced herd immunity in a randomly mixed population, especially in COVID-19.
PATHOGENETIC APPROACH IN TREATMENT OF DIABETIC AND VENOUS TROPHIC ULCERS USING PLASMATHERAPY AND LASER THERAPY
Authors: Kharchenko T.A. , Ivanova A.S. , Melekhovets O.K. , Orlovskyi V.F. , Melekhovets Iu.V.
Published: March 2021

In Ukraine more than 13,000 lower limb amputations are performed per year, of which about 8,000 are due to vascular lesions, and more than 3,000 are associated with diabetes mellitus (DM).
The effectiveness of photodynamic therapy (PDT) in group 1 was assessed by the VCSS-1 and VCSS-2 scales. At baseline, the total score of clinical severity of CVI was 20.9 points, and two weeks later – 15.71 points, which shows an improvement by 24.83% (p≤0.05). The effectiveness of PDT in group 2 was assessed by the S(AD) SAD-1 scales at baseline and S(AD) SAD-2 at 2 weeks. The overall score on the scale S(AD) SAD-1 was 13.91 points, two weeks later it improved by 11.65% (12.29 points), which shows a much slower rate of normalization of the clinical picture in patients with diabetes compared with CVI.
The effectiveness of plasma therapy in group 1 was assessed by the VCSS-1 and VCSS-3 scales. The total score of clinical severity of CVI after 6 weeks of treatment was 9.72 points, indicating an improvement in clinical status by 53.49% from baseline (20.9 points) (p≤0.05). In group 2, the evaluation of the effectiveness of plasma therapy was based on a comparison of the scales S(AD) SAD-1 and S(AD) SAD-3. The overall score of clinical severity at 6 weeks was 6.39 points, indicating an improvement by 54.06% from baseline (13.91 points).
Analysis of the ulcer healing dynamics in group 1 revealed 0 points (no active ulcers) in 87.5% of patients (28 patients), while in the remaining 4 patients the size of active ulcers was 1 point. In group 2, the dynamics of the area reduction showed slower results: in 74.2% of patients the TU area was 2 points, 0 points were achieved in 12.9% patients, in the remaining patients (12.9%) – 4 points.
Due to using of combined scheme of basic therapy, supplemented with PDT at the initial stage and plasma therapy in the granulation phase, it was possible to improve the dynamics of the rate of healing of TU and reduce the duration of treatment.
PEMAHAMAN IDENTITAS ETNIK (ETHNIC IDENTITY) UNTUK MENGEMBANGKAN TOLERANSI MASYARAKAT KOTA METRO LAMPUNG
Authors: Widodo Widodo
Published: March 2021

Keanekaragaman suku, bahasa, adat, dan agama merupakan keniscayaan sekaligus menjadi kekayaan bangsa Indonesia. Namun, dinamika interaksi sosial dalam masyarakat sering mengakibatkan terjadinya konflik antar etnis maupun antar agama karena kurangnya pengetahuan dan pemahaman terhadap Ethnic Identity (Identitas Etnik). Artikel ini bertujuan memotret keragaman masyarakat dan pemahaman identitas etnis dalam mengembangkan toleransi masyarakat Kota Metro, Lampung, menggunakan pendekatan kualitatif deskriptif. Data dikumpulkan melalui pengamatan langsung serta menelaah berbagai sumber dari media cetak maupun elektronik. Hasilnya menunjukkan bahwa; a) berdasarkan telaah berita pada media massa, tidak pernah terjadi konflik yang melibatkan suku dan agama di Kota Metro seperti yang terjadi di beberapa kabupaten lainnya di Provinsi Lampung, b) Adanya kerjasama antar pemerintah dan masyarakat untuk mewujudkan kerukunan hidup yang harmonis melalui kegiatan rutin seperti peringatan hari jadi Kota Metro dan upacara Pemilihan Bujan Gadis Lampung (Buyai Nuban) yang melibatkan seluruh elemen masyarakat tanpa membedakan latar belakang etnis yang bersangkutan. Kata Kunci: Identitas Etnis, Toleransi, Keanekaragaman
Integrated regression and whale optimization algorithm to post-stroke rehabilitation analysis: A case study for serious games (Preprint)
Authors: Ismail Waidah
Published: March 2021

BACKGROUND

Stroke is one of the leading causes of death and long-term disability worldwide. The primary goal of post-stroke rehabilitation is to maximize the independence of the affected individuals by facilitating both neurological and compensatory functional recoveries in their daily lives.

OBJECTIVE

The research objective finding the best games settings for MIRA.

METHODS

This paper presents an integrated study, using multiple linear regression (MLR) and whale optimization algorithm, for optimizing the post-stroke rehabilitation performance using Medical Interactive Rehabilitation Assistant (MIRA).

RESULTS

Results demonstrated that the developed MLR models for average acceleration and distance were significant, with P=0.018 and P<0.000, respectively. Data from 41 stroke patients revealed that the maximum muscle strength that can be achieved was 2.56 cm/s2 while the maximum distance was 104.83 cm. The results showed that all patients outperformed the optimal average acceleration value by between 6% and 29%, whereas only two patients outperformed the optimal distance value.

CONCLUSIONS

The results from this study may be integrated using MIRA (exergames) to guide therapists in finding the best combination of input settings that can maximise the performance output of post-stroke patients.

CLINICALTRIAL

None
PENERAPAN METODE FUZZY TSUKAMOTO UNTUK MENDIAGNOSA PENYAKIT LEPTOSPIROSIS
Authors: Sinaga Mikha Dayan , Sembiring Nita Sari Br. , Sianturi Charles Jhony Mantho , Sianturi Charles Jhony Mantho
Published: March 2021

Leptospirosis merupakan penyakit endemis yang dapat menular dari hewan ke manusia. Penyakit ini dapat menyebar dengan cepat di daerah yang beriklim tropis. Manusia dapat terjangkit oleh penyakit ini melalui kontak dengan urine hewan pengerat yang telah terinfeksi oleh bakteri leptospira, atau melalui kontak dengan air, tanah atau makanan yang terlah terkontaminasi oleh bakteri leptospira. Kondisi lingkungan yang kurang bersih dapat mempercepat penyebaran penyakit ini. Gejala yang ditimbulkan oleh penyakit leptospirosis juga memiliki kemiripan dengan gejala-gejala dari penyakit lain seperti diare, batuk dan demam. Hal ini dapat membuat penyakit ini susah untuk didiagnosa. Peneliti menggunakan metode fuzzy tsukamoto untuk melakukan diagnosa terhadap penyakit leptospirosis. Metode fuzzy tsukamoto dipilih karena dianggap mampu untuk melakukan penelusuran terhadap suatu penyakit melalui gejala-gejala yang telah dimuat dalam suatu basis aturan. Metode fuzzy tsukamoto juga dapat melakukan perhitungan nilai kepastian dari setiap penelusuran yang dilakukan. Hasil dari penelitian ini yaitu terbentuknya suatu mesin inferensi yang dapat digunakan untuk mendiagnosa penyakit leptospirosis.
A patient with hepatocellular carcinoma who developed invasive pulmonary aspergillosis after corticosteroid treatment
Authors: Sato Shintaro , Yamada Sho , Nishizawa Tomotaka , Oba Tomohiro , Kawabe Rie , Yamakawa Hideaki , Akasaka Keiichi , Amano Masako , Matsushima Hidekazu
Published: March 2021

Corticosteroid administration can be a trigger of the onset of invasive
pulmonary aspergillosis in patients with hepatocellular carcinoma. It is
necessary to pay attention to the presence of cirrhosis, which may be
the basis of hepatocellular carcinoma especially when administering
systemic corticosteroid.
ANALISISIS SUASANA TOKO, LOKASI, DAN MEDIA SOSIAL PENGARUHNYA TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN DI KOPI AENK
Authors: Suryana Popo , Tresnawati Tanti
Published: March 2021

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh suasana toko, lokasi, dan media sosial terhadap keputusan pembelian konsumen di Kopi Aenk baik secara parsial maupun simultan. Metode penelitian yang digunakan adalah deskriptif dan verifikatif dengan jumlah sampel 91 responden. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan menyebarkan kuesioner. Metode analisis data yang digunakan adalah analisis uji validitas, analisis reliablitas, analisis regresi linier berganda, korelasi berganda, uji hipotesis, dan koefisien determinasi. Hasil penelitan ini menunjukan bahwa variabel suasana toko, lokasi, media sosial dan keputusan pembelian berada pada kategori kurang setuju. Secara parsial variabel suasana toko lebih besar pengaruhnya terhadap keputusan pembelian yaitu sebesar 42,7%, sedangkan varabel lokasi pengaruhya terhadap keputusan pembelian yaitu sebesar 24,6%, dan variabel media sosial pengaruhnya terhadap keputusan pembelian yaitu sebesar 22,2%. Sehingga didapatkan pengaruh suasana toko, lokasi, dan media sosial terhadap keputusan pembelian sebesar 89,5%.
An Analysis of the Linguistic Errors Made by Students in Saudi Arabian Schools in the Acquisition of the Auxiliary “Do”: A Comparison Between Boys’ and Girls’ Performances
Authors: Mussa’ad Khalid Aslaim Rasha
Published: March 2021

Recently there has been an upsurge in research into why students of foreign languages make mistakes. There have been many reasons given including interference of the mother tongue and over-generalisation of the rules of the language being studied. This research is concerned with the reasons for mistakes but will concentrate on a particular focus, i.e. the mistakes made by English language students regarding the auxiliary verb “do”. This is seen as a particularly difficult area for many foreign students of English language as this linguistic term does not feature in many other languages and is, therefore, a problem for some language students to grasp.It is hoped that reasons for the many mistakes (i.e. omissions, incorrect verb tense, etc.) can be identified and that from this identification, methods can be found to teach this term in a way that will allow students to grasp the concept and retain it throughout their language- learning careers.This dissertation is based on an error analysis of English written performances by students in the Third Grade (equivalent to Ninth Grade elsewhere) of the Intermediate Boys and Girls’ schools in the Kingdom of Saudi Arabia. It focuses on the examination and analysis of the students’ performances in a translation test. This should reveal information about some of the students’ errors in the acquisition of the auxiliary “do”, and other factors which might affect their English language learning. Furthermore, this dissertation seeks to find out whether there are any disparities in the responses of each of the two groups to the translation test which may be attributable to gender.
Hubungan Kejadian Post Dural Puncture Headache (PDPH) pada Pasien Sectio Caesarea dengan Anestesi Spinal di Rumah Sakit M Tahun 2019
Authors: Karnina Resiana , Putri Mutiara
Published: March 2021

Latar belakang: menurut data Riset Kesehatan Dasar (Riskesdas) tahun 2018, proses persalinan dengan operasi caesar di Indonesia mencapai 17,6% dari seluruh total kelahiran. Persalinan melalui sectio caesarea di Indonesia mengalami peningkatan dan akan mengakibatkan peningkatan penggunaan anestesi spinal yang memiliki komplikasi berupa Post Dural Puncture Headache (PDPH). Tujuan: untuk mengetahui hubungan kejadian Post Dural Puncture Headache (PDPH) terhadap usia, status gizi, dan riwayat PDPH pasien yang menjalani sectio caesarea dengan anestesi spinal di Rumah Sakit M. Metode: penelitian ini menggunakan metode cross sectional serta uji chi square. Sampel pada penelitian ini adalah pasien yang menjalani sectio caesarea dengan anestesi spinal di Rumah Sakit M pada bulan Juni – November 2019 dengan jumlah 125 sampel. Hasil: didapatkan 2(1,6%) pasien yang mengalami kejadian PDPH. Seluruh kejadian PDPH terjadi pada usia dewasa (26 – 45 tahun) dengan status gizi normal dan tidak memiliki riwayat PDPH. Pada hasil analisis didapatkan tidak terdapat hubungan antara kejadian PDPH terhadap usia (p=0,415) dan tidak terdapat hubungan antara kejadian PDPH terhadap status gizi (p=0,924). Kesimpulan: tidak terdapat hubungan antara kejadian Post Dural Puncture Headache (PDPH) terhadap usia dan status gizi pasien yang menjalani sectio caesarea dengan anestesi spinal di Rumah Sakit M pada bulan Juni – November 2019.
Business Simulation, Student Competency, And Learning Outcomes
Authors: M. N. Duka Christiana F. Dharmastuti, Syarief Darmoyo, R. A. Gunawan,
Published: March 2021

The shifting paradigm in the learning process changes with technological advances and the internet. The learning process is through conventional classes with teacher center learning and is changing towards student center and experiential learning. Unika Atma Jaya's management program develops learning using IT platforms for business simulations to train students' way of thinking about business processes within the company virtually. This study wants to examine how a business simulation class student's experience impacts student business competency and learning outcomes in learning Business Simulation. The results showed that student experience through perceived usefulness and perceived enjoyment affected learning outcomes mediated by student business competency.
Strategi Komunikasi Dosen Perguruan Tinggi Swasta dalam Perkuliahan Daring Saat Pandemi Covid-19
Authors: Levine Michelle , Winduwati Septia
Published: March 2021

Covid-19 pandemic had brought significant changes in the education sector. Social distancing to suppress the spread of this virus is a main reason to arrange online learning activities using new media virtual meeting. This changes makes lecturers need to adapting in ability to convey learning material properly so that lecturers need to have a new strategies in online learning activities. This thesis aims to know how the communication strategies of lecturers on teaching and learning in online process during the Covid-19 pandemic. The main theoretical concepts are used strategy of communication, new media, educational communication, and distance learning. The main concept in this thesis is strategy of communication, new media, educational communication, and distance learning. The methods of data collection in this thesis were used interviews and literature study. Interviews were conducted with four informants who works as lectures at Jakarta. This thesis shows that the lecturer analyzes the media who used for online learning, online learning is also filled with problem-based learning methods, adding or subtracting substance.Pandemi Covid-19 membawa perubahan yang signifikan dalam sektor Pendidikan. Pembatasan jarak untuk menekan penyebarluasan virus menjadi alasan utama diadakannya perkuliahan daring. Perubahan ini membuat dosen harus beradaptasi agar proses perkuliahan dapat berjalan dengan baik. Dosen harus memiliki strategi baru dalam perkuliahan daring. Penelitian ini bertujuan untuk mencari tahu strategic komunikasi dosen perguruan tinggi swasta dalam perkuliahan daring di masa pandemi covid-19. Konsep utama yang digunakan adalah strategi komunikasi, media baru, komunikasi pendidikan, dan pembelajaran jarak jauh. Penelitian dilakukan secara deskriptif kualitatif dengan metode pengumpulan data berupa wawancara dan studi pustaka. Wawancara dilakukan kepada empat orang narasumber yang berprofesi sebagai dosen di perguruan tinggi swasta yang terletak di Jakarta. Penelitian ini menunjukkan bahwa dosen melakukan analisa terhadap media-media yang digunakan untuk pembelajaran daring, pembelajaran daring juga dipenuhi oleh metode problem based learning, memanfaatkan fitur-fitur yang tersedia, melakukan pengurangan atau penambahan substansi atau bobot tugas dan materi, serta bermain dengan tempo dan intonasi saat berbicara.
Strategi Marketing Public Relations Kopi Kenangan dalam Membangun Brand Awareness
Authors: Chayadi Scelly Alvionita , Loisa Riris , Sudarto Sudarto
Published: March 2021

The rapid growth of the coffee business in Indonesia especially JABODETABEK, has resulted in very tight competition for entrepreneurs in the coffee sector, this has made coffee shop entrepreneurs have to be able and must have the right strategy in dealing with this competition. The purpose of this study is to determine the Marketing Public Relations strategy of Kopi Kenangan in building brand awareness for the last 3 years. The theory used in this research is Whalen's 7 step Strategic Planning Process. The method used in this research is qualitative with the case study method. The data collection technique used was in-depth interviews. The results of this study indicate that the Marketing Public Relations of Kopi Kenangan wants to instill the mindset of "Affordable with High Quality Coffee" into the minds of consumers by using the Marketing Public Relations strategy consisting of pull, push and pass carried out by PR & Communications Kopi Kenangan. So that the process of maintaining brand awareness starts from not realizing the original brand of Kopi Kenangan, to the peak of the mind which means the success of Kopi Kenangan as a coffee brand that is able to develop and compete.Pesatnya pertumbuhan bisnis kopi yang ada di Indonesia terutama JABODETABEK sehingga menimbulkan persaingan yang sangat ketat bagi para pengusaha bidang kopi, hal tersebut membuat para pengusaha kedai kopi harus mampu dan harus mempunyai strategi yang tepat dalam menghadapi persaingan tersebut. Tujuan dari penelitian ini adalah mengetahui strategi Marketing Public Relations Kopi Kenangan dalam membangun brand awareness selama 3 tahun terakhir. Teori yang digunakan dalam penelitian ini adalah Whalen’s 7 step Strategic Planning Process. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan metode studi kasus. Teknik pengumpulan data yang digunakan adalah wawancara mendalam (depth interview). Hasil penelitian ini menunjukan bahwa Marketing Public Relations Kopi Kenangan ingin menanamkan mindset “Affordable with High Quality Coffee” kedalam benak konsumen dengan menggunakan strategi Marketing Public Relations yang terdiri dari pull, push and pass yang dilakukan oleh PR & Communications Kopi Kenangan. Sehingga proses untuk mempertahankan brand awareness yang dimulai dari tidak menyadari merek awal Kopi Kenangan berdiri, sampai pada puncak pikiran yang berarti keberhasilan Kopi Kenangan sebagai brand kopi yang mampu berkembang dan bersaing.
PARTICIPATORY DESIGN DALAM KAJIAN PERANCANGAN STANDARDISASI MUSEUM SULTAN MAHMUD BADARUDDIN II
Authors: Budi Haswati Sri Maharani , Safari Erica Albertina , Harwinanto Agrie Pratama
Published: March 2021

Dalam beberapa dekade terakhir, berbagai jenis museum di berbagai belahan dunia semakin gencar mengajak masyarakat untuk terlibat merayakan gairah berbudaya melalui berbagai jenis aktivitas. Mereka memperkenalkan mediamedia yang variatif dan berhasil mematahkan stereotip lama bahwa museum cenderung dikenal sebagai bangunan tempat penyimpanan koleksi dari warisan masa lampau semata. Sehingga muncul gagasan bahwa ditawarkannya pengalaman yang interaktif merupakan salah satu faktor utama yang mendorong orang-orang mau kembali mengunjungi museum. Apalagi, idealnya keberadaan museum dapat pula berkontribusi terhadap pemberdayaan komunitas masyarakat setempat. Namun faktanya, sebagian besar museum di luar Jawa masih jauh tertinggal di belakang dan masih terhalang oleh keterbatasan dana serta sumber daya manusia dalam upaya mengembangkan kualitasnya secara mandiri. Maka dari itu, penerapan Participatory Design menjadi sebuah alternatif di antara pendekatan desain konvensional lain yang dapat dimanfaatkan untuk menjembatani visi misi museum dengan kebutuhan masyarakat yang disasarnya. Penelitian ini merupakan tahapan awal dari perancangan desain yang menggunakan metode kombinasi (Observasi, wawancara, hingga analisis konten), dimaksudkan untuk mengidentifikasi kendala yang dihadapi oleh museum Sultan Mahmud Badaruddin II sehingga dapat menawarkan rancangan solusi yang tepat dari sudut pandang keilmuan desain. Sekaligus berfungsi merumuskan data siap olah yang dibutuhkan dalam tahapan perancangan desain selanjutnya agar mencapai standardisasi museum yang telah ditargetkan.

Kata kunci: Museum, Participatory Design, Desain, Komunitas
Fault-tolerant quantum error correction code conversion
Authors: Hill Charles D. , Fowler Austin G. , Wang David S. , Hollenberg Lloyd C.L.
Published: March 2021

In this paper we demonstrate how data encoded in a five-qubit quantum error correction code can be converted, fault-tolerantly, into a seven-qubit Steane code. This is achieved by progressing through a series of codes, each of which fault-tolerantly corrects at least one error. Throughout the conversion the encoded qubit remains protected. We found, through computational search, that the method used to convert between codes given in this paper is optimal.
The Programmed Multiple C–H Bond Functionalization of 4-Hydroxyquinoline and Its Medicinal Potential
Authors: Ronzon Quentin , Zhang Wei , Casaretto Nicolas , Mouray Elizabeth , Florent Isabelle , Nay Bastien
Published: March 2021

The introduction of substituents on bare heterocyclic scaffolds can selectively be achieved by directed C–H functionalization. However, such methods have only occasionally been used, in an iterative manner, to decorate various positions of a medicinal scaffold to build chemical libraries. We herein report the multiple, site selective, metal-catalyzed C–H functionalization of a "programmed" 4-hydroxyquinoline. This medicinally privileged template indeed possesses multiple reactive sites for diversity-oriented functionalization, of which four were targeted. The C-2 and C-8 decorations were directed by an N-oxide, before taking benefit of an O-carbamoyl protection at C-4 to perform a Fries rearrangement and install a carboxamide at C-3. This also released the carbonyl group of 4-quinolones, the ultimate directing group to functionalize position 5. Our study highlights the power of multiple C–H functionalization to generate diversity in a biologically relevant library, after showing its strong antimalarial potential.
Endoscopic hemostasis in the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature
Authors: Feleshtynskyi Ya. P. , Oparin S. O. , Sorokin B. V. , Boiarska M. G. , Lutsenko D. V.
Published: March 2021

Objective. To improve the efficacy of endoscopic hemostasis for the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature.

Materials and methods. In 2017-2020 yrs period the analysis of efficacy of endoscopic hemostasis was done in 160 patients, ageing 40-85 yrs old, for the ulcer gastro-duodenal hemorrhage. The patients were distributed into two groups: the main - 80 patients, in whom high-frequency biological welding electro-ligature was performed, and a control one - 80 patients, in whom monopolar thermal argon-plasm coagulation was conducted.

Results. In the main Group a primary hemostasis was achieved in 77 (96.3%) patients. Early recurrence of hemorrhage have occurred in 3 (3.8%) patients. In a control Group a primary hemostasis was achieved in 66 (82.5%) patients. Recurrence of the hemorrhage have occurred in 14 (17.5%) patients.

Conclusion. Endoscopic hemostasis for the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature, is achieved due to the impedance action of modulated signal of a high-frequency current as well as the adaptive system of automatic guidance of the welding process and a contact between special endoscopic probe, owing a concave electrode, with bleeding vessel, leading to its complete obliteration. Application of welding electro-ligature for endoscopic hemostasis in the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature, guarantees more secure residual hemostasis, than application of monopolar thermal argon-plasm coagulation, peculiarly in hemorrhage from vessels owing 2 - 4 mm diameter. As a result, the hemorrhage recurrence rate have had reduced down to 3.8% (in the control Group - 18.0%).
Procedure of complex braided wrapping of ascending aorta in her poststenotic dilation while doing correction of aortal stenosis
Authors: Popov V. V. , Bolshak A. A.
Published: March 2021

Objective. To study clinical possibilities of original procedure of the ascending aorta braid-like bandage for her poststenotic dilation while performance of the aortal stenosis surgical correction.

Materials and methods. To the main Group 196 patients were included those, who were operated on for prevailing aortal stenosis, conjoined with poststenotic dilation of ascending aorta. In accordance to the echocardiographic investigation data the ascending aorta diameter preoperatively have constituted (47.7 ± 1.7) mm. In all the patients the aortal valve prosthesis was performed together with complex braided wrapping of ascending aorta. Into the control group 121 patients were included, in whom Bentall intervention was accomplished with vascular prosthesis of ascending aorta.

Results. Hospital lethality in the main group have constituted 0.5%. Diameter of ascending aorta in the moment of hospital discharge have constituted (39.1 ± 1.5) mm, and in late follow-up period - (40.3 ± 1.1) mm.

Conclusion. Basing on clinical experience gained, it is expedient to recommend the original procedure of braided wrapping of ascending aorta in presence of her poststenotic dilation while performing surgical correction of prevailing aortal stenosis.
Does Digital Media Literacy Influence Students’ Perception of Hoax?
Authors: Wijayati Primardiana Hermilia , Mandasari Nur Octavi , Usman Rizman
Published: March 2021

The purpose of this study was to find out whether there was the significant relationship between digital media literacy and students' perception of hoax. This research uses descriptive correlation methods with surveys as data collection. Respondents in this study were students of diploma, undergraduate, and graduate from 18 study programs at the Faculty of Letters, Universitas Negeri Malang. This study uses surveys conducted online using the Google Form website. The data were then analyzed by using Pearson’s Product Moment Correlation in SPSS software. The results showed that there was a significant relationship between the level of digital media literacy and the perception of hoaxes, and it was in the moderate correlation. Based on the review of related literature, moderate correlation was occur due to several factors such as biased thinking, easily provoked age group, and difficulties in finding accurate media agencies.
Investigation of Transferable Skills’s Vocational Teachers in Terms of Work Culture and Age
Authors: Purnomo Purnomo
Published: March 2021

This research is a quantitative study using an ex-post facto design. The sample of 102 teachers using simple random sampling technique. Data collection uses questionnaires to measure work culture and age and perceptions of transferable skills. . This study aims to (1) determine the influence of work culture and age with the perception of transferable skills of productive teachers in TKI study programs in Malang City and Malang Regency and Batu City; (2) knowing the influence of work culture with the perception of transferable skills of productive teachers in TKI study programs in Malang City and Malang Regency and Batu City; and (3) knowing the effect of age with the perception of transferable skills of productive teachers in TKI study programs in Malang City and Malang Regency and Batu City. The results of this study include: (1) there is a significant influence of work culture and age with productive teacher transferable skills in Malang City and Malang Regency and Batu City; (2) there is a significant influence of work culture with productive teacher skills transferables perceptions in Malang City and Malang Regency and Batu City; and (3) there is a significant influence of teacher age with perceptions of transferable skills of productive teachers in Malang City and Malang Regency and Batu City. It can be concluded that the variable that has the highest influence is training experience.
Enhancing the Student Involvement in Learning Speaking through Impressive Personal Experience Material (IPEM)
Authors: Hasna Hasna
Published: March 2021

Based on the observation in some speaking classes in Indonesia, most of the students reluctant to involve themselves in speaking learning process. Therefore, the study is aimed to find out: (1) the extent to which the influence of IPEM in making the students involve themselves in learning Speaking; and (2) the students’ interest in attending the Speaking class through IPEM. Students’ activities were observed, recorded, and noted during the teaching and learning process; and given questionnaires and interview in the last meeting in the class. The results show that: (1) IPEM enhances the student involvement in learning Speaking especially for most of those who get low involvement (33.3%) can achieve moderate involvement (56.7%); and (2) most of the students are interested in attending the Speaking class in which 89.6% of them are categorized high interested and the mean score of students’ questionnaire answer is 82 which is categorized high interested.
RE-VISITED; ARE FOODS FRIEND OR FOE FOR CANCER?
Authors: DAYI Taygun , ÖNİZ Adile
Published: March 2021

Worldwide, the second most common disease which has high mortality range is cancer. Unhealthy lifestyle such as sedentary life, unbalanced nutrition habits etc. may increase cancer incidence. There is a bidirectional relation between foods and cancer. Some foods (red meat, processed meat products, salty foods, sugar, alcohol etc.) may cause to cancer and some of them such as fruits, vegetables, seeds, legumes, milk and dairy products, olive oil etc. may protect our body against cancer. In this mini-review; we aimed to re-assess effects of nutrition and some foods on cancer risk.