bluuebunny/crossref_metadata_2025 huggingface dataset:
Mobile Phone-based Colorimetric Detection of Perfluorocarboxylic Acids using Porphyrin Hosts
Authors: Taylor Chloe M. , Breadmore Michael C. , Kilah Nathan L.
Published: May 2022

Perfluorinated carboxylic acids (PFCAs) are widespread, potentially harmful, and difficult to detect pollutants. Here we investigate the use of three colorimetric porphyrin host molecules with chain lengths derived from different PFCA precursors as visual sensors for a range of different sized perfluorocarboxylates. We found that modifications to the length of the fluorinated chains led to subtleties in binding preferences and the resultant colorimetric (RGB) response. Host-guest interactions were investigated with UV-visible spectroscopy, and ImageJ software analysis was used to relate RGB information from digital photographs with binding and perceived colors. The CIE76 formula for color difference was used for the visual estimation of PFCA concentrations from generated color charts. Color responses were also parameterized to generate calibration curves from known concentrations of perfluorooctanoic acid so that total PFCA concentrations could be estimated with less than 20% error using a phone camera across a 10 ppb (parts per billion) – 16 ppm (parts per million) range.
Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging
Authors: Shen Hanchen , Sun Feiyi , Zhu Xinyan , Zhang Jianyu , Ou Xinwen , Zhang Jianquan , Xu Changhuo , Sung Herman H. Y. , Williams Ian D. , Chen Sijie , Kwok Ryan T. K. , Lam Jacky W. Y. , Sun Jianwei , Zhang Fan , Tang Ben Zhong
Published: May 2022

Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) using small-molecule dyes is highly potential for clinical use. However, many NIR-II dyes suffer from the emission quenching effect and extremely low quantum yields (QYs) in the practical usage forms. The AIE strategy has been successfully utilized to develop NIR-II dyes with donor-acceptor (D-A) structures with acceptable QYs in the aggregate state, but there is still a large room for QY improvement. Here, we rationally designed NIR-II emissive dye named TPE-BBT and its derivative (TPEO-BBT) by changing the electron-donating triphenylamine unit to tetraphenylethlene (TPE). Their nanoparticles exhibited ultrahigh relative QYs of 31.5% and 23.9% in water, respectively. By using an integrating sphere, the absolute QY of TPE-BBT nanoparticles was measured to be 1.8% in water. Its crystals showed an absolute QY of 10.4%, which is the highest value among organ-ic small molecules reported so far. The optimized D-A interaction and the higher rigidity of TPE-BBT in the aggregate state are believed to be the two key factors for its ultrahigh QY. Finally, we utilized TPE-BBT for NIR-II photoluminescence (PL) and chemiluminescence (CL) bioimaging through successive CL resonance energy transfer and Förster resonance energy transfer processes. The ultrahigh QY of TPE-BBT realized an excellent PL imaging quality in mouse blood vessels, and an excellent CL imaging quality in the local arthrosis inflammation in mice with a high signal-to-background ratio of 130. Thus, the design strategy presented here brings new possibilities for the development of bright NIR-II dyes and NIR-II bioimaging technologies.
İlk Trimester Serum Lipid Profili ile Postterm Gebelik İlişkisi
Authors: GÜLÜCÜ Selim , ÇELİK Samettin , SOYER ÇALIŞKAN Canan , ÇELİK Sebahattin
Published: May 2022

Amaç: Çalışmada ilk trimesterdeki lipid profili ile postterm gebelik (PTG) arasındaki ilişkiyi ve lipid profilinin PTG için bir öngörü kriteri olup olamayacağını değerlendirmeyi amaçladık.Materyal ve Metot: Çalışmaya postterm dönemdeki 329 (vaka grubu) ve term dönemdeki 97 (kontrol grubu) gebe dahil edildi. Hastaların demografik bilgileri, doğum şekilleri, ilk trimester lipid profilleri (total kolesterol, trigliserid, HDL-K, LDL-K, VLDL-K düzeyleri) ile doğan bebeklerin APGAR skoru ve yenidoğan yoğun bakım (YDYB) kabulu kaydedildi. Çalışmada gruplar arasındaki lipid profil farklılıkları değerlendirildi.Bulgular: Gruplar arasında yaş, gebelik sayısı, parite ve vücut kitle indeksi (VKI) açısından anlamlı farklılık saptanmazken, ortalama APGAR skorları (p<0,001) ve YDYB ihtiyacı (p<0,001) açısından anlamlı farklılık tespit edildi. PTG grubunda sezaryen (C/S) olma oranı term gruba göre daha yüksekti ve fark istatistiksel olarak anlamlı bulundu (p<0,001). Gruplar arasında lipid profilleri değerlendirildiğinde; total kolesterol, trigliserid, HDL-K, LDL-K ve VLDL-K düzeylerinin PTG grubunda anlamlı olarak daha düşük olduğu saptandı (p<0,05).Sonuç: Çalışmada, ilk trimester lipid düzeyi düşüklüğü ile PTG arasında anlamlı bir ilişki tespit edildi. Gebede ilk trimesterdeki düşük lipid seviyeleri, PTG’i öngörmek için bir kriter olarak değerlendirilebilir. Bununla beraber PTG’ye neden olabilecek başka faktörlerde bulunduğundan lipid profili ile PTG arasındaki ilişkinin daha iyi anlaşılabilmesi için destekleyici prospektif çalışmalara ihtiyaç vardır.
Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice
Authors: Li Gang , Li Xin , Yang Li , Wang Shuyue , Dai Yulin , Fekry Baharan , Veillon Lucas , Tan Lin , Berdeaux Rebecca , Eckel-Mahan Kristin , Lorenzi Philip L , Zhao Zhongming , Lehner Richard , Sun Kai
Published: May 2022

Carboxylesterase 1d (Ces1d) is a crucial enzyme with a wide range of activities in multiple tissues. It has been reported to localize predominantly in ER. Here, we found that Ces1d levels are significantly increased in obese patients with type 2 diabetes. Intriguingly, a high level of Ces1d translocates onto lipid droplets where it digests the lipids to produce a unique set of fatty acids. We further revealed that adipose tissue–specific Ces1d knock-out (FKO) mice gained more body weight with increased fat mass during a high fat-diet challenge. The FKO mice exhibited impaired glucose and lipid metabolism and developed exacerbated liver steatosis. Mechanistically, deficiency of Ces1d induced abnormally large lipid droplet deposition in the adipocytes, causing ectopic accumulation of triglycerides in other peripheral tissues. Furthermore, loss of Ces1d diminished the circulating free fatty acids serving as signaling molecules to trigger the epigenetic regulations of energy metabolism via lipid-sensing transcriptional factors, such as HNF4α. The metabolic disorders induced an unhealthy microenvironment in the metabolically active tissues, ultimately leading to systemic insulin resistance.
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission
Authors: Zeeshan Mohammad , Brady Declan , Markus Robert , Vaughan Sue , Ferguson David , Holder Anthony A , Tewari Rita
Published: May 2022

The centriole/basal body (CBB) is an evolutionarily conserved organelle acting as a microtubule organising centre (MTOC) to nucleate cilia, flagella, and the centrosome. SAS4/CPAP is a conserved component associated with BB biogenesis in many model flagellated cells. Plasmodium, a divergent unicellular eukaryote and causative agent of malaria, displays an atypical, closed mitosis with an MTOC (or centriolar plaque), reminiscent of an acentriolar MTOC, embedded in the nuclear membrane. Mitosis during male gamete formation is accompanied by flagella formation. There are two MTOCs in male gametocytes: the acentriolar nuclear envelope MTOC for the mitotic spindle and an outer centriolar MTOC (the basal body) that organises flagella assembly in the cytoplasm. We show the coordinated location, association and assembly of SAS4 with the BB component, kinesin-8B, but no association with the kinetochore protein, NDC80, indicating that SAS4 is part of the BB and outer centriolar MTOC in the cytoplasm. Deletion of the SAS4 gene produced no phenotype, indicating that it is not essential for either male gamete formation or parasite transmission.
Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption
Authors: Lyu Lin , Feng Ru , Zhang Mingnan , Xie Xiaoqing , Liao Yinjing , Zhou Yanjiao , Guo Xiaokui , Su Bing , Dorsett Yair , Chen Lei
Published: May 2022

Fundamental to viral biology is identification and annotation of viral genes and their function. Determining the level of coronavirus gene expression is inherently difficult due to the positive stranded RNA genome and the identification of subgenomic RNAs (sgRNAs) that are required for expression of most viral genes. We developed a bioinformatic pipeline to analyze metatranscriptomic data from 20 independent studies encompassing 588 individual samples and 10 coronavirus species. This comparative analysis defined a core sgRNA repertoire for SARS-CoV-2 and found novel sgRNAs that could encode functional short peptides. Relevant to coronavirus infectivity and transmission, we also observed that the ratio of Spike sgRNA to Nucleocapsid one is highest in SARS-CoV-2, among the β-coronaviruses examined. Furthermore, the adjustment of this ratio can be made by modifications to the viral RNA replication machinery, representing a form of viral gene regulation that may be involved in host adaption.
Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis
Authors: Parween Shama , Alawathugoda Thilina T , Prabakaran Ashok D , Dheen S Thameem , Morse Randall H , Emerald Bright Starling , Ansari Suraiya A
Published: May 2022

Protein O-GlcNAcylation is a dynamic, nutrient-sensitive mono-glycosylation deposited on numerous nucleo-cytoplasmic and mitochondrial proteins, including transcription factors, epigenetic regulators, and histones. However, the role of protein O-GlcNAcylation on epigenome regulation in response to nutrient perturbations during development is not well understood. Herein we recapitulated early human embryonic neurogenesis in cell culture and found that pharmacological up-regulation of O-GlcNAc levels during human embryonic stem cells’ neuronal differentiation leads to up-regulation of key neurogenic transcription factor genes. This transcriptional de-repression is associated with reduced H3K27me3 and increased H3K4me3 levels on the promoters of these genes, perturbing promoter bivalency possibly through increased EZH2-Thr311 phosphorylation. Elevated O-GlcNAc levels also lead to increased Pol II-Ser5 phosphorylation and affect H2BS112O-GlcNAc and H2BK120Ub1 on promoters. Using an in vivo rat model of maternal hyperglycemia, we show similarly elevated O-GlcNAc levels and epigenetic dysregulations in the developing embryo brains because of hyperglycemia, whereas pharmacological inhibition of O-GlcNAc transferase (OGT) restored these molecular changes. Together, our results demonstrate O-GlcNAc mediated sensitivity of chromatin to nutrient status, and indicate how metabolic perturbations could affect gene expression during neurodevelopment.
Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells
Authors: Kikuchi Koji , Sakamoto Yasuhisa , Uezu Akiyoshi , Yamamoto Hideyuki , Ishiguro Kei-ichiro , Shimamura Kenji , Saito Taro , Hisanaga Shin-ichi , Nakanishi Hiroyuki
Published: May 2022

Microtubule (MT) dynamics are modulated through the coordinated action of various MT-associated proteins (MAPs). However, the regulatory mechanisms underlying MT dynamics remain unclear. We show that the MAP7 family protein Map7D2 stabilizes MTs to control cell motility and neurite outgrowth. Map7D2 directly bound to MTs through its N-terminal half and stabilized MTs in vitro. Map7D2 localized prominently to the centrosome and partially on MTs in mouse N1-E115 neuronal cells, which expresses two of the four MAP7 family members, Map7D2 and Map7D1. Map7D2 loss decreased the resistance to the MT-destabilizing agent nocodazole without affecting acetylated/detyrosinated stable MTs, suggesting that Map7D2 stabilizes MTs via direct binding. In addition, Map7D2 loss increased the rate of random cell migration and neurite outgrowth, presumably by disturbing the balance between MT stabilization and destabilization. Map7D1 exhibited similar subcellular localization and gene knockdown phenotypes to Map7D2. However, in contrast to Map7D2, Map7D1 was required for the maintenance of acetylated stable MTs. Taken together, our data suggest that Map7D2 and Map7D1 facilitate MT stabilization through distinct mechanisms in cell motility and neurite outgrowth.
Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
Authors: Ambikan Anoop T , Svensson-Akusjärvi Sara , Krishnan Shuba , Sperk Maike , Nowak Piotr , Vesterbacka Jan , Sönnerborg Anders , Benfeitas Rui , Neogi Ujjwal
Published: May 2022

Genome-scale metabolic models (GSMMs) can provide novel insights into metabolic reprogramming during disease progression and therapeutic interventions. We developed a context-specific system-level GSMM of people living with HIV (PLWH) using global RNA sequencing data from PBMCs with suppressive viremia either by natural (elite controllers, PLWHEC) or drug-induced (PLWHART) control. This GSMM was compared with HIV-negative controls (HC) to provide a comprehensive systems-level metabo-transcriptomic characterization. Transcriptomic analysis identified up-regulation of oxidative phosphorylation as a characteristic of PLWHART, differentiating them from PLWHEC with dysregulated complexes I, III, and IV. The flux balance analysis identified altered flux in several intermediates of glycolysis including pyruvate, α-ketoglutarate, and glutamate, among others, in PLWHART. The in vitro pharmacological inhibition of OXPHOS complexes in a latent lymphocytic cell model (J-Lat 10.6) suggested a role for complex IV in latency reversal and immunosenescence. Furthermore, inhibition of complexes I/III/IV induced apoptosis, collectively indicating their contribution to reservoir dynamics.
OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
Authors: Hortle Elinor , Tran Vi LT , Wright Kathryn , Fontaine Angela RM , Pinello Natalia , O’Rourke Matthew B , Wong Justin J-L , Hansbro Philip M , Britton Warwick J , Oehlers Stefan H
Published: May 2022

Pathogenic mycobacteria inhibit inflammasome activation to establish infection. Although it is known that potassium efflux is a trigger for inflammasome activation, the interaction between mycobacterial infection, potassium efflux, and inflammasome activation has not been investigated. Here, we use Mycobacterium marinum infection of zebrafish embryos and Mycobacterium tuberculosis infection of THP-1 cells to demonstrate that pathogenic mycobacteria up-regulate the host WNK signalling pathway kinases SPAK and OXSR1 which control intracellular potassium balance. We show that genetic depletion or inhibition of OXSR1 decreases bacterial burden and intracellular potassium levels. The protective effects of OXSR1 depletion are at least partially mediated by NLRP3 inflammasome activation, caspase-mediated release of IL-1β, and downstream activation of protective TNF-α. The elucidation of this druggable pathway to potentiate inflammasome activation provides a new avenue for the development of host-directed therapies against intracellular infections.
Visualization on Twitter Activism Networks and Opinion Leaders: The Case of #FreeWestPapua
Authors: Ardiyanti Handrini , Revianti Sunarwinadi Ilya , Rusadi Udi
Published: May 2022

Introduction: This study tries to visualize the Twitter activism networks and their opinion leader with the case of #FreeWestPapua activism. This study is important to find out who the opinion leaders and their networks are. This study also provides an overview of how the opinion leader frames opinions about #FreeWestPapua activism on Twitter.

Methods: This research used Social Media Network Analysis (SMNA). The SMNA method is the application of the Social Network Analysis (SNA) method to examine conversations on social media. Data collection and data processing are collected and visualised with Netlytic.

Findings: The results showed that there are 13 opinion leaders and all of the opinion leaders are from outside Papua. This study concluded that there is alienation in separatist activism in the case of #FreeWestPapua on Twitter. The most influential opinion leader in the separatist activism on Twitter is @VeronicaKoman who has the biggest values and is also active to frame public opinion. #FreeWestpapua activism framed Indonesia as a colonial in diagnostic framing and #FreeWestPapua as a solution in prognostic framing. To attract support from the international community, opinion leaders in #FreeWestPapua activism took advantage of the various #BlackLivesMatter issue and other international moments such as Korindo news by BBC.com.
Originality: Although a lot of research on the Free Papua Movement has been done, there has never been a study explains about who opinion leaders and their networks and also how they are framed public opinion about #FreeWestPapua activism on social media.
Educational Forum
Authors: Wilson Margaret , Deeks John
Published: May 2022

Details of trade union traiing, 1951 Watersiders' reunion, Industrial Relations Society Meetings and Courses and Seminars.
Нестандартная занятость как форма использования рабочего времени (российский и зарубежный опыт)
Authors:   Всероссийский научно-исследовательский институт труда, Разумов А.А. , Цыганкова И.В. ,   Российская академия народного хозяйства и государственной службы при Президенте РФ
Published: May 2022

Нестандартная занятость является основной тенденцией изменения социально-трудовых отношений в современных условиях. Появление многих ее форм обусловлено трансформацией организации рабочего времени и его распределения на предприятиях различных видов экономической деятельности. В связи с этим в монографии дается представление об отдельных формах нестандартной занятости: как новых, возникших в начале XXI в., так и традиционных, существовавших ранее. Особое внимание уделено факторам, влияющим на выбор форм занятости, экономическим и социальным преимуществам и недостаткам отдельных форм с позиции использования рабочего времени. Авторами предложена методика оценки влияния отдельных форм нестандартной занятости на рынок труда на макро-, мезо- и микроуровне. По сравнению с предыдущем изданием осовременена и дополнена статистика. Определенное внимание уделено влиянию кризиса на рынке труда, вызванного коронавирусной пандемией, на трансформацию отношений и форм нестандартной занятости. В связи с этим авторы вводят в научный оборот экономики труда две новые категории — “ковидная занятость” и “ковидная бедность” — и дают их определения. В рамках исследования сформулированы основные направления улучшения использования рабочего времени на основе развития нестандартной занятости. Монография адресована представителям органов законодательной и исполнительной власти, отвечающим за политику в области занятости, руководителям и специалистам предприятий, научным работникам, аспирантам, студентам экономических специальностей вузов.
Una metodología de co-labor: repensarnos desde la acción en huertos educativos
Authors: Mazzotti Pabello Giovanna M. , Nava Nasupcialy Kay Nicté
Published: May 2022

En este trabajo se presenta un planteamiento que teje lo ontológico, lo epistémico y el método para presentar una posible ruta metodológica de abordaje participativo que permita visibilizar las experiencias y fortalecer los procesos de las organizaciones autogestivas que accionan desde intereses distintos a los de las organizaciones modernas. En ella se da preponderancia al cambio de valores ligados a una ética de reciprocidad y responsabilidad hacia las y los integrantes del colectivo y a la ampliación de los espacios de vida. Para ello analizamos la experiencia de la Red de Huertos Educativos y Comunitarios de Xalapa, Veracruz, México, partiendo del análisis del lugar desde el que se enuncia la investigación y de las diversas decisiones y reflexiones metodológicas que se fueron tomando hacia la co-construcción de categorías de análisis.
Topraksız Baş Salata (Lactuca sativa var. capitata) Yetiştiriciliğinde Farklı Tuzluluk Düzeylerinin Bitki Besin Elementlerinin Üzerindeki Etkileri
Authors: AKAT SARAÇOĞLU Özlem , KILIÇ Cenk Ceyhun
Published: May 2022

Araştırmada, topraksız tarım koşullarında gerçekleştirilen baş salata (Lactuca sativa var. capitata) yetiştiriciliğinde katı ortam kültüründe 3 farklı tuzluluk [(Kontrol (EC0), Kontrol+1 dS m-1 (EC1) ve Kontrol+2 dS m-1 (EC2)] düzeyinin verim ve bitki besin elementleri üzerindeki etkileri incelenmiştir. Belirlenen hedefe ulaşmak üzere, PE malzemeden yapılmış kanallarda içerisine perlit ortamı kullanılarak Bombola F1 çeşidi yetiştirilmiştir. Bu amaçla, yetiştiricilik dönemi sonunda bitkilerin bitki besin elementi analizleri gerçekleştirilmiştir. I. üretim döneminde, bitkilere günlük ortalama 0,25-3,76 L bitki-1, II. üretim döneminde ise ortalama 0,33-3,50 L bitki-1 arasında değişen miktarda besin çözeltisi uygulanmıştır. I. üretim döneminde konulardan drene olan ortalama besin çözeltisi miktarlarının 0,15-2,29 litre bitki-1, II. üretim döneminde ise 0,26-2,43 L bitki-1 arasında değişmiştir. Tuzluluk düzeylerinin baş salata yapraklarındaki N, P, K, Mg, Zn ve Mn içerikleri üzerindeki ana etkisi istatistiksel anlamda önemli bir fark yaratmıştır. Tuzluluk düzeylerinin baş salata yapraklarındaki Ca, Fe ve Cu içerikleri üzerindeki etkisi ise önemsiz bulunmuştur (p<0,05). Elde edilen sonuçlara dayanarak, topraksız tarım baş salata yetiştiriciliğinin belli bir konsantrasyona sahip tuzlu sulama sularının kullanılarak gerçekleştirilebileceği yaklaşımında bulunmak mümkündür.
Escala Escuelas Saludables y Resilientes: Evidencias Argentinas de Validez de Constructo, Estructura Interna y Confiabilidad
Authors:   Universidad Nacional de Rafaela, Salessi Solana
Published: May 2022

Las organizaciones saludables y resilientes son aquellas que implementan recursos y prácticas saludables, cuentan con empleados saludables y obtienen resulta-dos positivos. Dicho constructo se encuentra exigua-mente explorado en el ámbito académico. Por este motivo, esta investigación se orientó a desarrollar una escala que permita operacionalizar el constructo en organizaciones educativas. Se realizó un estudio instrumental de corte transversal en dos fases. La fase I tuvo como objetivo explorar la capacidad discriminativa de los ítems y conformar la versión preli-minar del instrumento. La fase II apuntó a examinar la estructura factorial y la confiabilidad de la escala. Se estudiaron dos muestras no probabilísticas de 104 docentes (Fase I) y 242 docentes (Fase II) de la ciudad de Rafaela. Se obtuvo una solución de cinco factores oblicuos que explican el 69.75%.”. La confiabilidad fue satisfactoria (ω= .90). Se encontraron correlaciones positivas con satisfacción laboral y compro-miso organizacional (r > .55, p < .001). Futuros estudios deberían analizar las propiedades psicométricas de la escala en otras muestras y culturas con miras a aportar nuevas evidencias de validez del instrumento aquí desarrollado.
Polymorphism of the Calpastatin (CAST) and Growth Differentiation Factor 9 (GDF9) genes in Akkaraman Sheep Breed
Authors: KIRIKÇI Koray
Published: May 2022

Objective: In this study, the gene polymorphisms of Calpastatin (CAST) and Growth Differentiation factor 9 (GDF9) were determined in Akkaraman sheep breed.Material and Methods: Genomic DNA was obtained from blood samples of 50 Akkaraman sheep. All samples for CAST and GDF9 were genotyped by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method using the enzymes MspI and Hhal.Results: Three (MM, MN, and NN) and two (GG and GA) genotypes, respectively, were detected at the CAST and GDF9 genes. The frequencies of the genotypes MM, MN and NN were determined to be 44 %, 54 % and 2 %, respectively. The frequencies of the GG and GA genotypes were found to be 84 % and 16 %, respectively. The AA genotype was not found.Conclusion: The study showed for the first time that the Akkaraman breed carries the GDF9 G1 mutation and has sufficient variation in the CAST. Previous studies provided that both genes can be used as biomarkers for increasing lambing yield and growth rates. Therefore, in order for the studied genes to be used as biomarkers in the Akkaraman breed, association studies should first be performed.
Phenotypic Correlations between Carcass Part Yields and Meat Quality Characteristics in Quails
Authors: GÜLER Hüseyin Cem
Published: May 2022

Objective: This study aimed to determine phenotypic correlations between carcass part yields (breast and thigh yield) and meat quality characteristics (pHu, lightness, redness, yellowness, chroma, hue, thawing loss, cooking loss, water holding capacity, and texture) in Japanese quails.Material and Methods: This study was carried out on a total of 130 Japanese quails with mixed sexes. Twenty-four hours after slaughter, pHu and color measurements were performed in the right breast muscle to determine meat quality characteristics.Results: Mean breast and thigh muscle yields were determined as 24.19% and 14.41%, respectively. Significant phenotypic correlations were found for carcass part yields and meat quality characteristics in quail meat. While determined negative significant (p<0.05) phenotypic correlations for pHu and lightness (-0.193), yellowness (-0.288), chroma (-0.266), and thawing loss (-0.248); pHu’s relationships with redness, hue, water holding capacity and, texture were insignificant.Conclusion: In this study, the significant negative phenotypic correlation determined between pHu and lightness shows that selection for breast meat lightness in quails can affect the ultimate pH and lead to an improvement in quality characteristics, and this situation can be used to reduce meat quality defects.
Yapay Zeka Teknolojilerinin Hayvancılıkta Kullanımı
Authors: TUVAY Niyazi Hayrullah , ERMETİN Orhan
Published: May 2022

Yapay zekâ teknolojisi sayesinde üretilen yazılımlar, çeşitli sensörler ve akıllı makineler birçok sektörde başarılı bir şekilde kullanılmaktadır. Yapay zekâ uygulamaları ile hayvancılık alanında sağlıklı kararlar verebilmek, doğru yorumlar yapabilmek ve çok daha fazla sayıda değişkeni daha kısa zamanda inceleyip sonuca varmak mümkün olabilmektedir. Bu teknolojiler, insan işgücünü ve insan kaynaklı hataları büyük ölçüde azaltarak verimlilik ve ürün kalitesinin iyileştirilmesine de yardımcı olmaktadır. Yapay zekâ teknolojileri, sağladığı avantaj ve kolaylıklarla hayvancılık alanında giderek yaygın bir şekilde kullanılmaya başlanmıştır. Hayvan yetiştiriciliğinde uygulamaları gittikçe artan yapay zekâ programları ile hayvanların duygusal durumları, beslenme alışkanlıkları, süt verimlerinin kontrolü ve sürü yönetimi gibi pek çok alanda insan müdahale ve hatası ortadan kaldırılmaktadır. Hayvanları tanımlamak için uygulanan küpe, işaret, etiket ve benzeri dış etmenleri de ortadan kaldırarak, hem iş yükünü ve maliyeti azaltmakta hem de hayvan refahına katkı sunmaktadır. Ayrıca biyogüvenlik, hastalık takibi ve kontrolü, hayvanların izlenmesi, çiftlik yönetimi, çiftlik hayvanlarında büyümenin kontrolü ve benzeri konularda kullanılmaktadır. Bu çalışmada hayvan yetiştiriciliğinde yapay zekâ uygulamaları hakkında bilgilere ve örneklere yer verilmiştir.
Beç Tavuklarında Yerleşim Sıklığının Büyüme, Kesim ve Karkas Özelliklerine Etkisi
Authors: BOZ Mehmet Akif , ERENSOY Kadir , UÇAR Ahmet , SARICA Musa
Published: May 2022

Amaç: Bu çalışmada, üç farklı yerleşim sıklığında yetiştirilen beç tavuklarının büyüme performansı, yem tüketimi, kesim ve karkas özelliklerinin belirlenmesi amaçlanmıştır.Materyal ve Metot: Çalışma kapalı yetiştirme sisteminde üç farklı yerleşim sıklığında (m2’de 6.6, m2’de 9.3, m2’de 12 beç tavuğu) yetiştirilen toplamda 252 beç tavuğu ile yürütülmüştür. Günlük yaşta, 2, 4, 6, 8, 10, 12 ve 13. haftalarda canlı ağırlık, yem tüketimi ve yemden yararlanma oranı belirlenmiştir. Kesim ve karkas özellikleri 13. haftada tespit edilmiştir. Bulgular: Çalışmada 6. hafta ve sonrasında yüksek yerleşim sıklığına sahip grupta daha düşük canlı ağırlık tespit edilmiştir. Kümülatif yem tüketimi 4. haftadan sonra düşük yerleşim sıklığında yetiştirilen beç tavuklarında daha yüksek bulunmuştur. Bununla birlikte yemden yaralanma oranı ise 6. hafta ve sonrasında düşük yerleşim sıklığı grubunda daha yüksek belirlenmiştir. Kesim ve karkas ağırlıkları ve oranları üzerine ise yerleşim sıklığının önemli bir etkisi tespit edilmemiştir. Sonuç: Yerleşim sıklığının 13 haftalık kesim yaşındaki beç tavuklarında canlı ağırlık, yem tüketimi, yemden yararlanma oranı ve ölüm oranı üzerine önemli etkisi olduğu, kesim ve karkas özelliklerini ise etkilemediği belirlenmiştir. Büyüme performansı ve üretim maliyetleri bakımından en ekonomik yetiştiriciliğin birim alanda 9-10 beç tavuğu ile sağlanabileceği söylenebilir. Ancak beç tavuğu gibi alternatif kanatlı türleri için doğal yaşam alanlarından çok farklı olan kapalı sistemlerde yetiştirmenin refah durumu ve doğal davranış özelliklerine etkilerini ortaya koyan ileri çalışmalara ihtiyaç duyulmaktadır.
Muş İlinde Kaba Yem Üretimi ve Yeterlilik Durumu
Authors: HANOĞLU ORAL Hülya
Published: May 2022

Bu çalışmada, Muş ilinde kaba yem üretimi ve bu üretimin mevcut hayvan varlığına yeterlilik durumu incelenmiştir. 2019 yılında ilin büyükbaş ve küçükbaş hayvan varlığı toplam 307.660 hayvan birimi olup, bunların sadece yaşama payı besin maddesi gereksinimlerini kaba yemlerle karşılamak için 1.403.699 ton kaliteli kaba yeme ihtiyaç duyulduğu hesaplanmıştır. İlde çiftlik hayvanlarının temel kaba yem kaynağını doğal çayır ve meralar oluşturmaktadır. Ancak uzun yıllardır sürdürülen erken ve ağır otlatmalar meraların verim güçlerinin azalmasına yol açmıştır. Çayır meralar dışında kaliteli kaba yemin diğer önemli bir kaynağı olan yem bitkileri tarımı ise yeterli düzeyde değildir. 2019 yılında Muş ilinde çayır mera ve yem bitkileri tarımından elde edilen kaba yem üretimi 748.160 ton olarak hesaplandığından, mevcut kaliteli kaba yem üretiminin hayvanların yaşama payı besin maddesi gereksinimlerinin ancak %53.3’ünü karşıladığı sonucuna varılmıştır. Oysa rasyonel bir hayvan besleme için hayvanların yalnız yaşama payı gereksinimlerinin değil, yaşama payına ek olarak en az 5-7 kg süt üretiminin kaliteli kaba yemlerden karşılanması gerekmektedir. İlde kaliteli kaba yem açığı sap saman ve anız gibi niteliksiz yem kaynaklarından (507.369 ton) karşılanmakta ve yem değeri düşük olan bu yemler rasyonların temel bileşenini oluşturmaktadır. İlde hayvancılığın geliştirilmesi için öncelikle kaliteli kaba yem ihtiyacının yeterli, ucuz ve düzenli olarak karşılanması gerekmektedir.
CURRICULARIZAÇÃO DA EXTENSÃO NO CURRÍCULO NA EDUCAÇÃO PROFISSIONAL TECNOLÓGICA: UM CAMINHO POSSÍVEL NOS CURSOS TÉCNICOS
Authors: Delevedove Kesia Zoteli De Oliveira
Published: May 2022

No contexto educacional contemporâneo, não é mais possível fechar as portas da sala de aula e ensinar apenas o que está proposto no livro. Faz-se necessário inovar a atuação do profissional da educação, com a integração e interação dos alunos com a tecnologia, com a comunidade em que está inserido, bem como apresentar ao aluno possibilidades de atuar de maneira crítica e ser protagonista em sua realidade. Ao falar de educação mais cidadã, penso no papel do currículo. Na perspectiva de pensar o “como?” e o “por quê?", identifico possibilidades de "desengessar" os currículos presentes em nossas escolas, para o desenvolvimento do conhecimento crítico na sociedade, considerando a realidade e o cotidiano do estudante. Compreendendo o papel do currículo no processo de ensino e aprendizagem e que a escola não pode se limitar a uma educação bancária, esta pesquisa tem como objetivo maior: investigar a curricularização da extensão como elemento formativo na Educação Profissional e Tecnológica no nível técnico. Esta é uma pesquisa de mestrado em fase inicial e os resultados preliminares estão baseados nas primeiras observações feitas no cotidiano, in loco. Destaco que, apesar da “curricularização da extensão” ter sido institucionalizada apenas nos cursos de graduação, através da resolução do Conselho Nacional de Educação nº 7/2018, não há impeditivos para que possa acontecer em outros níveis educacionais, podendo impactar, inclusive, na redução do percentual de evasão escolar. Quando pensamos na Educação Profissional Tecnológica, pensamos na aproximação do estudante com o mundo do trabalho, com a realidade da sociedade em que vivemos, e, dentre os atores principais de oferta temos os Institutos Federais. Considerando a abordagem qualitativa, através de levantamentos bibliográficos, estudo de caso e diálogos com os atores envolvidos, esta pesquisa visa a elaboração de um programa de extensão tencionado a ser vinculado ao currículo dos cursos técnicos do Instituto Federal do Espírito Santo - campus Nova Venécia. Outrossim, a extensão universitária é um dos eixos de atuação dos Institutos Federais, em que busca a ruptura “dos muros da escola”, fomentando a dialogicidade com a sociedade. E, para realizar a aproximação com o mundo do trabalho de forma crítica, vislumbro a possibilidade de ambientar o aluno à vivência profissional, identificando a extensão como um caminho. Portanto, construir novos caminhos é muito desafiador mas, para que possamos contribuir para uma educação de qualidade, precisamos amadurecer nas discussões sobre currículo, e neste caso, enfatizando o aprofundamento na temática da “curricularização da extensão”.
Mechanomorphism—From Mechanical Dolls to Cyborgs: How Animation Characters Transform Under the Dominating Technogenic Paradigm
Authors:   Moscow State University, Higher School of Television, KRIVULYA NATALIA G.
Published: May 2022

The article studies the evolution of animated characters, which is influenced by the technocratic ideas and is based on the integration of human and artificial. There are such types of characters as doll, puppet, mechatron, robot, cyborg or artificial person (posthuman). The duality inherent in them is manifested, on the one hand, in the desire of an artificial creature to imitate a human being, and, on the other hand, in the desire of a human being to partly become a machine in order to overcome the biological imperfection. The ambivalent nature of created beings gives rise to conflicting feelings: from amusement and admiration to detachment, confusion and fear. While humans remain the point of reference in the development of such characters, the position of people in relation to artificial creations is changing. Until the 1960s–1970s, the dominant characteristic in the animation of artificial creatures was the desire to make them look more like biological beings. By the end of the twentieth century, the tendency changed to shifting away from human identity or to offering other variations of it. The reason for this is the pedaling of the idea of human imperfection, against which artificial creatures seem to be closer to the ideal. Not only has the position of the artificial towards the human altered: the distance between the two is also reducing, and they even come towards the point of convergence. Artificial beings appear as more perfect creatures, the main function of which is to save and preserve humans as a species.
Diegetic Invisible/Vanishing in Silent Cinema and its Origins
Authors:   State Institute for Art Studies, SALNIKOVA EKATERINA V.
Published: May 2022

The article studies the early silent cinema motif of disappearance or invisibility of bodies in a frame. In adventure and adventure-fantasy films, this motif performs a whole set of functions. Using the example of several films, I uncover its rich semantic potential. Further on, the mythological origins of the motif are analyzed, as are the role of theater, circus, attraction and fairy tale in the prehistory of the diegetic disappearing. Attention is paid to the aesthetics of the trick in Georges Méliès’ films, where the condition and location of the vanishing body remain uncertain. Narrative films suggest a more definite interpretation of the character’s disappearance. For instance, the final episode of the British film The Life of Charles Peace (1905) implies the hero’s death by execution. However, the invisibility of the body creates the illusion of a likely open finale. Another example is D. W. Griffith’s The Adventures of Dollie (1908) about a girl locked in a barrel and traveling down the river to be returned to her father in the end. The happy-end gives this melodrama a touch of fantasy, presenting America as a wise natural universe. Working with the motif of the diegetic invisible/disappearing is significant for the cinema aesthetics, regardless of the motivations and meaning of what is happening. The diversity of the diegetic invisible reflects the need of cinema to model the picture of the magical universe.
23 gennaio 2022: 100 anni fa il miracolo della terapia insulinica che continua oggi
Authors: B. Bolli Geremia , Porcellati Francesca , Lucidi Paola , G. Fanelli Carmine
Published: May 2022

It was January 23, 1922, when the first successful subcutaneous injection of a pancreatic extract, prepared by Banting and purified by Collip, was administered to Leonard Thompson, a young boy in diabetic ketoacidosis, at the Toronto General Hospital. That day is the birth of insulin therapy which over the years has saved tens of millions of lives of people. Animal extracted insulin has been continuously purified until human insulin and the insulin analogs have been obtained with the rDNA technique to substitute insulin according to physiology. Today basal-bolus insulin therapy in type 1 diabetes, and basal insulin in type 2 (possibly in combination with GLP-1 RA) remain the consolidated gold standards of insulin therapy in diabetes.
Insuline oltre l’insulina
Authors: Falcetta Pierpaolo , Garofolo Monia , Del Prato Stefano
Published: May 2022

Insulin pumps, or systems for Continuous Subcutaneous Insulin In-fusion (CSII), have changed from rudimentary devices with limited dosing flexibility to “smart” systems able to modulate insulin administration with greater flexibility and accuracy. The combination of insulin pump, continuous glucose monitoring and control algorithm now allows the automatic administration of insulin with an efficacy in glucose control never achieved previously. We review here the evolution in technology that has made possible this big advance in the care of diabetes.
Il ruolo della tecnologia nella gestione del bambino e dell’adolescente con diabete di tipo 1
Authors: Scaramuzza Andrea , Cherubini Valentino , Lombardo Fortunato , Rabbone Ivana
Published: May 2022

In Italy, it is estimated there are about 25,000 children and adolescents with type 1 diabetes between 0 and 18 years, most of whom using electronic devices for blood glucose control. Among these many have chosen a sensor for measuring blood glucose, often integrated, or combined with an insulin pump, preferably included in (advanced) hybrid closed-loop systems, that increasingly resemble artificial pancreases. This technology has seen an enormous progress in the last two decades, making these tools fundamental for improving glycemic control and the quality of life of patients with diabetes and their families. However, major challenges remain, including cybersecurity vulnerability, cost, and accessibility, with a substantial geographical variation in access to diabetes technologies. The hope is that the very recent guidelines of SID, AMD and SIEDP will help to rationalize and improve access to available technologies.
futuro possível
Authors: Barboza Arias Luis Miguel , Mourão Salheb do Amaral Ana Júlia
Published: May 2022

Objetivo: o objetivo deste trabalho é gerar uma discussão sobre duas práticas de desenvolvimento acontecidas no Brasil e na Costa Rica durante os primeiros meses da pandemia da Covid-19. A reflexão é acompanhada de insumos teóricos das abordagens pós-desenvolvimentistas, com a finalidade de aportar novos elementos de análise que contribuam para o aprofundamento da crítica epistemológica e sociopolítica aos processos de apropriação da natureza pelo modo de produção capitalista na América Latina e suas implicações nos tempos da Covid-19. Metodologia: quanto ao delineamento metodológico, as práticas de desenvolvimento apresentadas foram construídas como estudos de caso, em função do estipulado pela pesquisa qualitativa, que sugere a importância da identificação dos atores envolvidos na expressão de um fenômeno, suas interações complexas e o mapeamento das narrativas e estratégias de sobrevivência e resistência que emergem como formas de superação dos conflitos. Resultados: a análise dos resultados propõe um giro ontológico na abordagem reflexiva do desenvolvimento que é coincidente com a adoção de olhares alternativos para entender as crises socioambientais originadas no Antropoceno. Com o propósito de debater as possibilidades de análise que oferecem os novos olhares epistêmicos e onto-políticos, as duas experiências empíricas permitem exemplificar a inadequação das categorias tradicionais para atender os cenários de contingência, sendo pertinente a incorporação de abordagens não centrados em medidas de controle, securitização e planejamento. Conclusões: as conclusões sugerem que o conjunto destas reflexões permite uma melhor compreensão sobre as formas em que ciência, política e natureza articulam-se nas sociedades contemporâneas. Este conhecimento é fundamental nos estudos sobre as práticas de legitimação da democracia, os projetos alternativos de cidadania e o surgimento de novas identidades territoriais.
ANALYSIS OF THE REALITY OF THE TOURIST MOVEMENT IN ALGERIAN COASTAL CITIES. CASE STUDY OF THE CITY OF ALGIERS
Authors:   University of Sciences and Technology - Houari Boumediene, Department of Geography and Territorial Planning, Bab Ezzouar, Algiers, LAMINE Djamila , REZZAZ Mohamed Abdessamad ,   University of Sciences and Technology - Houari Boumediene, Department of Geography and Territorial Planning, Bab Ezzouar, Algiers, KHERROUR Louardi ,   University of Sciences and Technology - Houari Boumediene, Department of Geography and Territorial Planning, Bab Ezzouar, Algiers
Published: May 2022

Geographical research has been concerned with tourism studies in terms of studying the characteristics of tourist groups: their satisfaction, attitudes and level of awareness. The use of the behavioral approach became preferred by planners to know the desires of tourists to reach a realistic tourism strategy based on the opinions of the tourists themselves. This research aims to study the characteristics of the tourism movement in the city of Algiers, in order to identify the impressions of tourists about the visit and the most prominent problems they face in the development of tourism in the study area. The topic of the research deals with tourism movements by following the descriptive and analytical approach. Accordingly, the study concluded that the most promising type of tourism in the region is ecological, cultural and recreational tourism, and the summer and spring seasons represent the preferred seasons at the level of tourist movement, while tourists are from the northern states. - The central region constitutes the largest proportion of the number of tourists coming to the region, as the group predominates over young women between (26 - 39) years old, the majority of the number of tourists, and cars are the most widely used means of transportation.
The use of information and communication technologies in the activities of a modern teacher: a view from the inside
Authors:   Kremenchuk Mykhailo Ostrohradskyi National University, Istomina Nataliia Mykolaivna
Published: May 2022

Information and communication technologies occupy an important place in the life of a modern teacher. But their use is unsystematic. The purpose of this work is the specified area of information technology, the specified area of responsibility, and the space of tools and techniques that can be used by the teacher. To analyze the activities of teachers, we based on the principles of a unified model language, methods of systems analysis, and elements of the statistical information processing. As a result, the basic actors of the teacher’s activity are detemined: the state, the administration of the higher education institution, the management of the structural unit and the teacher himself. In the work "student" is considered not as an actor, but as a living environment for teaching, as the main goal for any teacher. Then we considered a teacher as the class with its required and optional attributes. These attributes are determined by state and social requirements for the modern teacher and have different states. Further the complex of the factors influencing on these attributes’ states formation are defined. Objective and subjective reasons that hinder the formation of attributes are analyzed. The resulting significant factors are distributed to the spheres of certain actors’ existence. The range of responsibilities and influence of actors on significant factors are determined. In analyzing the attributes of the teacher and the factors that contribute to or hinder their formation, open information from the reports of the Ministry of Education of Ukraine and state institutions for the collection of statistical information was used. Among the attributes are common to all teachers, regardless of the level of education they teaching. The study examined data on teachers of higher education and general secondary education (with an emphasis on teachers in grades 5-11). As a result, we emphasize the responsibilities of a teacher of higher education. We determine the range of tasks that teacher must solve in their daily work. We choose the tasks of teacher’s pedagogical activity, subjected to automation and unification. As a result, from a practical point of view, a range of elementary problems has been identified, the solution of ones can be accelerated and optimized. This work is the beginning of an article’s series devoted to solving each elementary problem from a defined list.
Characterization of Rice Blast Disease Using Greenness Index, Canopy Temperature and Vegetation Indices
Authors: Mandal Nandita
Published: May 2022

Blast diseases cause economically important damage to rice. Protective treatments help producers to secure good quality crops. In contrast, curative treatments based on visually detectable symptoms are often riskier and less effective because diseased crop plants may develop disease symptoms too late for curative treatments. On the other hand, the effect of blast severity levels on crop physiology (greenness index and canopy temperature) and vegetation indices may help in early detection of rice blast. Keeping this view, a field experiment was conducted at ICAR-VPKAS, Almora to study the effect of different rice blast severity levels on canopy temperature, greenness index and hyperspectral vegetation indices with 10 rice genotype each for upland and irrigated condition
Bio-efficacy of Bentazon against Weeds in Direct Seeded Rice under Kymore Plateau and Satpura Hill Zone
Authors: Tirkey Shweta
Published: May 2022

The experiment was conducted at Research Farm of Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur, Madhya Pradesh, India to study the “Bio-efficacy of Bentazon against Weeds in Direct Seeded Rice under Kymore Plateau and Satpura Hill zone” during kharif season of 2016 under edaphic and climatic conditions of Jabalpur (M.P.). The dominant weeds associated with direct seeded rice in the experimental field comprised of monocot like Echinochloa colona and Dinebra retroflexa, sedges like Cyperus iria and dicot weeds including Mullogo pentaphylla and Alternanthera philoxeroides. Experiment consisted of total ten treatments comprising of seven doses of Bentazon 600, 800, 1000, 1200, 1600, 1800 and 2000 g/ha, 2,4-D 380 g/ha as post-emergence, hand weeding twice at 20 and 40 DAS including weedy check, the experiment was laid out in randomized block design (RBD) with 03 replications. The post-emergence application of Bentazon at 1600 g/ha was found economically best suitable for effective control of dicot weeds in direct seeded rice.