bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Ni on Fe and Co-Fe Based Catalysts for High-Calorific Synthetic Natural Gas
Authors: Kim Tae-Young , Jo Seongbin , Lee Yeji , Kang Suk-Hwan , Kim Joon-Woo , Lee Soo-Chool , Kim Jae-Chang
Published: June 2021

Fe-Ni and Co-Fe-Ni catalysts were prepared by the wet impregnation method for the production of high-calorific synthetic natural gas. The influence of Ni addition to Fe and Co-Fe catalyst structure and catalytic performance was investigated. The results show that the increasing of Ni amount in Fe-Ni and Co-Fe-Ni catalysts increased the formation of Ni-Fe alloy. In addition, the addition of nickel to the Fe and Co-Fe catalysts could promote the dispersion of metal and decrease the reduction temperature. Consequently, the Fe-Ni and Co-Fe-Ni catalysts exhibited higher CO conversion compared to Fe and Co-Fe catalysts. A higher Ni amount in the catalysts could increase C1–C4 hydrocarbon production and reduce the byproducts (C5+ and CO2). Among the catalysts, the 5Co-15Fe-5Ni/γ-Al2O3 catalyst affords a high light hydrocarbon yield (51.7% CH4 and 21.8% C2–C4) with a low byproduct yield (14.1% C5+ and 12.1% CO2).
Epigenetic Regulation of Peroxisome Proliferator-Activated Receptor Gamma Mediates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease
Authors: Hajri Tahar , Zaiou Mohamed , Fungwe Thomas V. , Ouguerram Khadija , Besong Samuel
Published: June 2021

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in Western countries and has become a serious public health concern. Although Western-style dietary patterns, characterized by a high intake of saturated fat, is considered a risk factor for NAFLD, the molecular mechanisms leading to hepatic fat accumulation are still unclear. In this study, we assessed epigenetic regulation of peroxisome proliferator-activated receptor γ (PPARγ), modifications of gene expression, and lipid uptake in the liver of mice fed a high-fat diet (HFD), and in hepatocyte culture challenged with palmitic acid. Bisulfate pyrosequencing revealed that HFD reduced the level of cytosine methylation in the pparγ DNA promoter. This was associated with increased expression of the hepatic PPARγ, very low-density lipoprotein receptor (VLDLR) and cluster differentiating 36 (CD36), and enhanced uptake of fatty acids and very low-density lipoprotein, leading to excess hepatic lipid accumulation. Furthermore, palmitic acid overload engendered comparable modifications in hepatocytes, suggesting that dietary fatty acids contribute to the pathogenesis of NAFLD through epigenetic upregulation of PPARγ and its target genes. The significance of epigenetic regulation was further demonstrated in hepatocytes treated with DNA methylation inhibitor, showing marked upregulation of PPARγ and its target genes, leading to enhanced fatty acid uptake and storage. This study demonstrated that HFD-induction of pparγ DNA promoter demethylation increased the expression of PPARγ and its target genes, vldlr and cd36, leading to excess lipid accumulation, an important initiating mechanism by which HFD increased PPARγ and lipid accumulation. These findings provide strong evidence that modification of the pparγ promoter methylation is a crucial mechanism of regulation in NAFLD pathogenesis.
Extracellular Vesicles and Pancreatic Cancer: Insights on the Roles of miRNA, lncRNA, and Protein Cargos in Cancer Progression
Authors: Romano Roberta , Picca Anna , Eusebi Leonardo Henry Umberto , Marzetti Emanuele , Calvani Riccardo , Moro Loredana , Bucci Cecilia , Guerra Flora
Published: June 2021

Pancreatic cancer (PC) is among the most devastating digestive tract cancers worldwide. This cancer is characterized by poor diagnostic detection, lack of therapy, and difficulty in predicting tumorigenesis progression. Although mutations of key oncogenes and oncosuppressor involved in tumor growth and in immunosurveillance escape are known, the underlying mechanisms that orchestrate PC initiation and progression are poorly understood or still under debate. In recent years, the attention of many researchers has been concentrated on the role of extracellular vesicles and of a particular subset of extracellular vesicles, known as exosomes. Literature data report that these nanovesicles are able to deliver their cargos to recipient cells playing key roles in the pathogenesis and progression of many pancreatic precancerous conditions. In this review, we have summarized and discussed principal cargos of extracellular vesicles characterized in PC, such as miRNAs, lncRNAs, and several proteins, to offer a systematic overview of their function in PC progression. The study of extracellular vesicles is allowing to understand that investigation of their secretion and analysis of their content might represent a new and potential diagnostic and prognostic tools for PC.
Meta-Analysis of Adipose Tissue Derived Cell-Based Therapy for the Treatment of Knee Osteoarthritis
Authors: Agarwal Nikhil , Mak Christopher , Bojanic Christine , To Kendrick , Khan Wasim
Published: June 2021

Osteoarthritis (OA) is a degenerative disorder associated with cartilage loss and is a leading cause of disability around the world. In old age, the capacity of cartilage to regenerate is diminished. With an aging population, the burden of OA is set to rise. Currently, there is no definitive treatment for OA. However, cell-based therapies derived from adipose tissue are promising. A PRISMA systematic review was conducted employing four databases (MEDLINE, EMBASE, Cochrane, Web of Science) to identify all clinical studies that utilized adipose tissue derived mesenchymal stem cells (AMSCs) or stromal vascular fraction (SVF) for the treatment of knee OA. Eighteen studies were included, which met the inclusion criteria. Meta-analyses were conducted on fourteen of these studies, which all documented WOMAC scores after the administration of AMSCs. Pooled analysis revealed that cell-based treatments definitively improve WOMAC scores, post treatment. These improvements increased with time. The studies in this meta-analysis have established the safety and efficacy of both AMSC therapy and SVF therapy for knee OA in old adults and show that they reduce pain and improve knee function in symptomatic knee OA suggesting that they may be effective therapies to improve mobility in an aging population.
TCL1A, B Cell Regulation and Tolerance in Renal Transplantation
Authors: Brinas François , Danger Richard , Brouard Sophie
Published: June 2021

Despite much progress in the management of kidney transplantation, the need for life-long immunosuppressive therapies remains a major issue representing many risks for patients. Operational tolerance, defined as allograft acceptance without immunosuppression, has logically been subject to many investigations with the aim of a better understanding of post-transplantation mechanisms and potentially how it would be induced in patients. Among proposed biomarkers, T-cell Leukemia/Lymphoma protein 1A (TCL1A) has been observed as overexpressed in the peripheral blood of operational tolerant patients in several studies. TCL1A expression is restricted to early B cells, also increased in the blood of tolerant patients, and showing regulatory properties, notably through IL-10 secretion for some subsets. TCL1A has first been identified as an oncogene, overexpression of which is associated to the development of T and B cell cancer. TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell survival, growth, and proliferation. It has also been identified as interacting with others major actors involved in B cells differentiation and regulation, including IL-10 production. Herein, we reviewed known interactions and functions of TCL1A in B cells which could involve its potential role in the set up and maintenance of renal allograft tolerance.
Sensing Properties of NiO Loaded SnO2 Nanoparticles—Specific Selectivity to H2S
Authors: Stanoiu Adelina , Kuncser Andrei C. , Ghica Daniela , Florea Ovidiu G. , Somacescu Simona , Simion Cristian E.
Published: June 2021

NiO-loaded SnO2 powders were prepared involving two chemical procedures. The mesoporous SnO2 support was synthesized by a hydrothermal route using Brij 35 non-ionic surfactant as a template. The nickel loadings of 1 and 10 wt.%. NiO were deposited by the wet impregnation method. The H2S sensing properties of xNiO-(1-x)SnO2 (x = 0, 1, 10%) thick layers deposited onto commercial substrates have been investigated with respect to different potential interfering gases (NO2, CO, CO2, CH4, NH3 and SO2) over a wide range of operating temperatures and relative humidity specific for in-field conditions. Following the correlation of the sensing results with the morphological ones, 1wt.% NiO/SnO2 was selected for simultaneous electrical resistance and work function investigations. The purpose was to depict the sensing mechanism by splitting between specific changes over the electron affinity induced by the surface coverage with hydroxyl dipoles and over the band bending induced by the variable surface charge under H2S exposure. Thus, it was found that different gas-interaction partners are dependent upon the amount of H2S, mirrored through the threshold value of 5 ppm H2S, which from an applicative point of view, represents the lower limit of health effects, an eight-hour TWA.
Environmental Factors as a Cause of Differences in the Feet of Ecuadorian Children and Its Relation to Their Footwear
Authors: Martin-Casado Laura , Barquín Christian , Aldana-Caballero Alberto , Marcos-Tejedor Felix , Aguado Xavier
Published: June 2021

The objective of this study was to analyze the differences in foot measurements of Ecuadorian children according to their geographical location of residence, taking into account climatic differences (1). A total of 1662 children (2) participated in the study. Three groups were established: coast, mountains and amazonia. The type of footwear (3) used was recorded and the lengths, widths, perimeters, heights and angles of both (4) feet were analyzed with a 3D foot digitizer (5). The variable ‘fitting of the foot to footwear’ was also obtained. Children living in coastal areas presented greater lengths, widths, perimeters and heights compared to those living in the mountain (p > 0.001) and amazonia (p < 0.001) between ages 5 to 13. Mountain residents showed a greater first toe angle than coast residents (p > 0.001) aged 8 to 17. Children used shoes smaller than required by their foot length (p < 0.01). Ecuadorian children from the coast presented longer and wider feet with higher foot arches, whilst those from mountains presented greater first toe angle. The studied sample used footwear up to one size smaller than the size corresponding to their foot length. The fitting and type of footwear used according to climatic differences could be interfering with normal foot development.
Effect of a Larger Flush Volume on Bioavailability and Efficacy of Umbilical Venous Epinephrine during Neonatal Resuscitation in Ovine Asphyxial Arrest
Authors: Sankaran Deepika , Vali Payam , Chandrasekharan Praveen , Chen Peggy , Gugino Sylvia F. , Koenigsknecht Carmon , Helman Justin , Nair Jayasree , Mathew Bobby , Rawat Munmun , Nielsen Lori , Lesneski Amy L. , Hardie Morgan E. , Alhassen Ziad , Joudi Houssam M. , Giusto Evan M. , Zeinali Lida , Knych Heather K. , Weiner Gary M. , Lakshminrusimha Satyan
Published: June 2021

The 7th edition of the Textbook of Neonatal Resuscitation recommends administration of epinephrine via an umbilical venous catheter (UVC) inserted 2–4 cm below the skin, followed by a 0.5-mL to 1-mL flush for severe bradycardia despite effective ventilation and chest compressions (CC). This volume of flush may not be adequate to push epinephrine to the right atrium in the absence of intrinsic cardiac activity during CC. The objective of our study was to evaluate the effect of 1-mL and 2.5-mL flush volumes after UVC epinephrine administration on the incidence and time to achieve return of spontaneous circulation (ROSC) in a near-term ovine model of perinatal asphyxia induced cardiac arrest. After 5 min of asystole, lambs were resuscitated per Neonatal Resuscitation Program (NRP) guidelines. During resuscitation, lambs received epinephrine through a UVC followed by 1-mL or 2.5-mL normal saline flush. Hemodynamics and plasma epinephrine concentrations were monitored. Three out of seven (43%) and 12/15 (80%) lambs achieved ROSC after the first dose of epinephrine with 1-mL and 2.5-mL flush respectively (p = 0.08). Median time to ROSC and cumulative epinephrine dose required were not different. Plasma epinephrine concentrations at 1 min after epinephrine administration were not different. From our pilot study, higher flush volume after first dose of epinephrine may be of benefit during neonatal resuscitation. More translational and clinical trials are needed.
Proliferative Verrucous Leukoplakia Revisited: A Retrospective Clinicopathological Study
Authors: Ghosh Snehashish , Rao Roopa S. , Upadhyay Manoj K. , Kumari Karuna , Sanketh D. Sharathkumar , Raj A. Thirumal , Parveen Sameena , Alhazmi Yaser Ali , Jethlia Ankur , Mushtaq Shazia , Sarode Sachin , Reda Rodolfo , Patil Shankargouda , Testarelli Luca
Published: June 2021

(1) Objective: To review the criteria proposed by Cerero-Lapiedra et al. and to retrospectively identify the under-diagnosed disease in patients diagnosed with proliferative verrucous leukoplakia. (2) Materials and methods: In this study, we included patients who were diagnosed with leukoplakia (histological label consistent with the clinical diagnosis, n = 95), and cases with a final diagnosis within the spectrum of proliferative verrucous leukoplakia (n = 110) as defined by Batsakis et al. We applied the criteria proposed by Cerero-Lepiedra et al. to screen for the possible cases of proliferative verrucous leukoplakia. (3) Results: Although many of our patients satisfied specific isolated criteria, only 11 cases satisfied specific combinations of the guidelines to satisfy a diagnosis of proliferative verrucous leukoplakia. However, due to the lack of follow-up data, the disease is not confirmed in these 11 cases. (4) Conclusion: A limited number of cases of proliferative verrucous leukoplakia were diagnosed using the criteria given by Cerero-Lapiedra et al. The true natural history of the disease could not be studied due to the lack of follow-up data. (5) Clinical relevance: Proliferative verrucous leukoplakia presenting as hyperkeratosis or mild epithelial dysplasia are often not followed up, and they subsequently transform into carcinoma. Thus, clinicians must be vigilant whenever they encounter leukoplakia, especially with multifocal presentations. In such cases, the follow-up data are the key to understanding the true nature of the disease entity.
Investigation of Mechanical Properties for Basalt Fiber/Epoxy Resin Composites Modified with La
Authors: Li Chong , Wang Haoyu , Zhao Xiaolei , Fu Yudong , He Xiaodong , Song Yiguo
Published: June 2021

As an efficient reinforcing material in resin matric composites, the application of basalt fibers (BFs) in composites is limited by the poor interfacial adhesion between BFs and the resin matrix. In this study, to obtain the basalt fibers/epoxy resin composites with enhanced mechanical properties, the modification solution containing different concentrations of Lanthanum ions (La3+) was synthesized to modify the BFs surfaces to enhance the poor interfacial adhesion between BFs and the matrix. The morphology, the chemical structure and the chemical composition of the modified BFs surface were observed and detected by scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, respectively. The results show that, after BFs were soaked in the modification solution, the more active groups (C=O, –OH, C–O, etc.) were introduced to the BFs surfaces and effectively enhanced the bond strength between BFs and the resin matrix. The obtained mechanical performances of prepared basalt fibers/epoxy resin composites showed that the tensile strength, bending strength and interlaminar shear strength (ILSS) were improved with the modified BFs, and reached to 458.7, 556.7 and 16.77 Mpa with the 0.5 wt.% La. Finally, the enhancement mechanism of the modification solution containing La element is analyzed.
Angle-Resolved Intensity of Polarized Micro-Raman Spectroscopy for 4H-SiC
Authors: Chang Ying , Xiao Aixia , Li Rubing , Wang Miaojing , He Saisai , Sun Mingyuan , Wang Lizhong , Qu Chuanyong , Qiu Wei
Published: June 2021

Raman spectroscopy is an indispensable method for the nondestructive testing of semiconductor materials and their microstructures. This paper presents a study on the angle-resolved intensity of polarized micro-Raman spectroscopy for a 4H silicon carbide (4H-SiC) wafer. A generalized theoretical model of polarized Raman intensity was established by considering the birefringence effect. The distributions of angle-resolved Raman intensities were achieved under normal and oblique backscattering configurations. Experiments were performed on a self-built angle-resolved Raman system, which verified the validity of the proposed model and achieved the identification of crystal orientations of the 4H-SiC sample.
Multi-Dependency and Time Based Resource Scheduling Algorithm for Scientific Applications in Cloud Computing
Authors: Prakash Vijay , Bawa Seema , Garg Lalit
Published: June 2021

Workflow scheduling is one of the significant issues for scientific applications among virtual machine migration, database management, security, performance, fault tolerance, server consolidation, etc. In this paper, existing time-based scheduling algorithms, such as first come first serve (FCFS), min–min, max–min, and minimum completion time (MCT), along with dependency-based scheduling algorithm MaxChild have been considered. These time-based scheduling algorithms only compare the burst time of tasks. Based on the burst time, these schedulers, schedule the sub-tasks of the application on suitable virtual machines according to the scheduling criteria. During this process, not much attention was given to the proper utilization of the resources. A novel dependency and time-based scheduling algorithm is proposed that considers the parent to child (P2C) node dependencies, child to parent node dependencies, and the time of different tasks in the workflows. The proposed P2C algorithm emphasizes proper utilization of the resources and overcomes the limitations of these time-based schedulers. The scientific applications, such as CyberShake, Montage, Epigenomics, Inspiral, and SIPHT, are represented in terms of the workflow. The tasks can be represented as the nodes, and relationships between the tasks can be represented as the dependencies in the workflows. All the results have been validated by using the simulation-based environment created with the help of the WorkflowSim simulator for the cloud environment. It has been observed that the proposed approach outperforms the mentioned time and dependency-based scheduling algorithms in terms of the total execution time by efficiently utilizing the resources.
A PI Controller with a Robust Adaptive Law for a Dielectric Electroactive Polymer Actuator
Authors: Bernat Jakub , Kolota Jakub
Published: June 2021

Dielectric electroactive polymer actuators are new important transducers in control system applications. The design of a high performance controller is a challenging task for these devices. In this work, a PI controller was studied for a dielectric electroactive polymer actuator. The pole placement problem for a closed-loop system with the PI controller was analyzed. The limitations of a PI controller in the pole placement problem are discussed. In this work, the analytic PI controller gain rules were obtained, and therefore extension to adaptive control is possible. To minimize the influence of unmodeled dynamics, the robust adaptive control law is applied. Furthermore, analysis of robust adaptive control was performed in a number of simulations and experiments.
An L2 Cache Architecture Supporting Bypassing for Low Energy and High Performance
Authors: Park Jungwoo , Kim Soontae , Hou Jong-Uk
Published: June 2021

Conventional 2-level cache architecture is not efficient in mobile systems when small programs that do not require the large L2 cache run. Bypassing the L2 cache for those small programs has two benefits. When only a single program runs, bypassing the L2 cache allows to power it down removing its leakage energy consumption. When multiple programs run simultaneously on multiple cores, small programs bypass the L2 cache while large programs use it. This decreases conflicts in the L2 cache among those programs increasing overall performance. From our experiments using cycle-accurate performance and energy simulators, our proposed L2 cache architecture supporting bypassing is shown to be effective in reducing L2 cache energy consumption and increasing overall performance of programs.
Using X-ray CT Scanned Reconstructed Logs to Predict Knot Characteristics and Tree Value
Authors: Ji Airu , Cool Julie , Duchesne Isabelle
Published: June 2021

Research Highlights: Stand density was connected with wood quality and lumber production to develop a predictive model to better estimate tree value. Background and Objectives: The available standing wood volume in British Columbia (BC), Canada has consistently decreased since 1990. Better understanding the link between stand growth conditions, knot characteristics, the sawmilling process and product quality is essential in making informed forest management decisions and efficiently utilizing wood. The overall objective was to investigate and predict the impact of tree growth as affected by stand density on knot characteristics, lumber volume and value recoveries for two conifer species, two types of sawmills and three economic scenarios. Materials and Methods: Seventy-two amabilis fir and western hemlock trees were harvested from three stands located on Vancouver Island, BC. Sawlogs were scanned using an X-ray computed tomography (CT) scanner and images were processed to extract knot characteristics and reconstruct three-dimensional (3D) log models. The effects of three diameter at breast height (DBH) classes (30, 40 and 50 cm) and three stand densities on knot characteristics, including knot volume, number of knots, average knot area and knot/tree volume ratio, as well as the simulated lumber volume and value recoveries from two types of sawmills (i.e., Coastal and Interior) under three economic scenarios (i.e., baseline, optimistic, and pessimistic) were investigated. Results: As expected, the knot characteristics of both species increased with the DBH. The difference of knot distribution between amabilis fir and western hemlock suggests that the latter is more sensitive to growth site conditions. The sawmilling simulations revealed that the Coastal mill produced a lower lumber volume due to the type of products manufactured and the primary breakdown patterns being used. Conclusions: The developed linear mixed effects models based on the knot characteristics and tree features could predict the value of a standing tree and can be used for estimating preharvest stand value of similar Coastal Hem-Fir forests.
Control of N-Propanol Production in Simulated Liquid State Fermentation of Chinese Baijiu by Response Surface Methodology
Authors: Yin Yajie , Han Xinglin , Lu Yifan , Li Jinshan , Zhang Zongjie , Xia Xian , Zhao Shumiao , Liang Yunxiang , Sun Baoguo , Hu Yuanliang
Published: June 2021

N-propanol is a vital flavor compound of Chinese baijiu, and the proper n-propanol contents contribute to the rich flavor of Chinese baijiu. However, the excessive content of n-propanol in liquor will reduce the drinking comfort. Based on the Box–Behnken design principle, the response surface test was used to optimize the factors affecting the production of n-propanol in a simulated liquid state fermentation of Chinese baijiu, and the best combination of factors to reduce n-propanol content was determined. Results showed that the content ratio of additional glucose to threonine and temperature had a significant effect on the production of n-propanol (p = 0.0009 < 0.01 and p = 0.0389 < 0.05, respectively). The best combination of fermentation parameters obtained was: the ratio of additional glucose to threonine content was 6:4, the temperature was 32 °C, and the initial pH was 4.40. Under these conditions, the production of n-propanol was 53.84 ± 0.12 mg/L, which was close to the theoretical value. Thus, the fermentation parameter model obtained through response surface optimization is reliable and can provide technical guidance for regulating the production of n-propanol and realizing high-quality baijiu brewing.
Identifying the Food Sources of Selected Minerals for the Adult European Population among Rice and Rice Products
Authors: Bielecka Joanna , Markiewicz-Żukowska Renata , Nowakowski Patryk , Puścion-Jakubik Anna , Grabia Monika , Mielech Anita , Soroczyńska Jolanta , Socha Katarzyna
Published: June 2021

The problem of dietary deficiency of several essential elements among different stages of life is still observed. The consumption of whole grains (among others unprocessed rice) is recommended as a part of a healthy diet. This research aimed to determine the content of selected macro- and microelements in rice and rice products to verify whether the tested products could be regarded as a source of selected minerals in the diet of the adult European population. Methods: A total of 99 samples from 12 groups of rice products (basmati, black, brown, parboiled, red, wild, white rice and expanded rice, rice flakes, flour, pasta, and waffles) were obtained. The atomic absorption spectrometry method (AAS) was used to determine the content of Ca, Cu, Fe, Mg, Mn, Se and Zn in the study material. Results: The average measured contents of Ca, Cu, Fe, Mg, Mn, Se and Zn were as follows: 226.3 ± 160.6 mg/kg, 3.6 ± 2.8 mg/kg, 9.4 ± 7.0 mg/kg, 618.0 ± 498.4 mg/kg, 16.7 ± 10.0 mg/kg, 242.9 ± 140.4 µg/kg and 19.5 ± 15.0 mg/kg, respectively. Statistical analyses confirmed the differences in the levels of the studied elements between the subgroups of processed and unprocessed products. Considering the tolerable upper intake level of studied elements, the tested products could be regarded as safe to consume. Conclusion: All tested products can be recommended as a source of Cu, Mn, and Se, while a majority of studied products can be considered a source of Mg and Zn in the diet of the adult European population.
Amaranth Supplementation Improves Hepatic Lipid Dysmetabolism and Modulates Gut Microbiota in Mice Fed a High-Fat Diet
Authors: Yang Yongshou , Fukui Rikako , Jia Huijuan , Kato Hisanori
Published: June 2021

Diet-induced obesity is often associated with gut microbiota dysbiosis, lipid metabolism disorders, and chronic inflammation. Consumption of the pseudocereal Amaranthus mangostanus has multiple nutritional benefits. We investigated the effects of dietary amaranth on lipid metabolism and gut microbiota in high-fat (HF) diet-fed mice. C57BL/6J mice were provided either a control diet, HF diet, or HF diet containing 10% amaranth powder (Ama) for 8 weeks. Ama supplementation significantly reduced the levels of triglycerides, total cholesterol, and phospholipids in the liver. Moreover, Ama supplementation downregulated the expression of lipogenesis-related genes including Hmgcr, Fdt1, and Sgle in the liver. The gut microbiota analysis showed that Ama supplementation reversed HF diet-induced reduction in bacterial diversity and richness. Additionally, beta diversity analysis of the inter-group variability in community structure showed a clear separation between the HF and Ama groups. Linear discriminant analysis effect size analysis revealed that 11 taxa were enriched in the Ama group, whereas 9 taxa were increased in the HF group. We found that family Porphyromonadaceae and unclassified S24-7 showed a strong positive and negative correlation with the lipid parameters, respectively. Taken together, these results indicated that dietary Ama may attenuate HF diet-induced deterioration of gut microbiota structure and hepatic lipid metabolism.
Nitrate Modulates Lateral Root Formation by Regulating the Auxin Response and Transport in Rice
Authors: Wang Bobo , Zhu Xiuli , Guo Xiaoli , Qi Xuejiao , Feng Fan , Zhang Yali , Zhao Quanzhi , Han Dan , Sun Huwei
Published: June 2021

Nitrate (NO3-) plays a pivotal role in stimulating lateral root (LR) formation and growth in plants. However, the role of NO3- in modulating rice LR formation and the signalling pathways involved in this process remain unclear. Phenotypic and genetic analyses of rice were used to explore the role of strigolactones (SLs) and auxin in NO3--modulated LR formation in rice. Compared with ammonium (NH4+), NO3- stimulated LR initiation due to higher short-term root IAA levels. However, this stimulation vanished after 7 d, and the LR density was reduced, in parallel with the auxin levels. Application of the exogenous auxin α-naphthylacetic acid to NH4+-treated rice plants promoted LR initiation to levels similar to those under NO3- at 7 d; conversely, the application of the SL analogue GR24 to NH4+-treated rice inhibited LR initiation to levels similar to those under NO3- supply by reducing the root auxin levels at 10 d. D10 and D14 mutations caused loss of sensitivity of the LR formation response to NO3-. The application of NO3- and GR24 downregulated the transcription of PIN-FORMED 2(PIN2), an auxin efflux carrier in roots. LR number and density in pin2 mutant lines were insensitive to NO3- treatment. These results indicate that NO3- modulates LR formation by affecting the auxin response and transport in rice, with the involvement of SLs.
Spatiotemporal Variability of Extreme Wave Storms in a Beach Tourism Destination Area
Authors: Guerra-Medina Daniel , Rodríguez Germán
Published: June 2021

This study explores the spatiotemporal variability of extreme wave storms around the Canary archipelago, with special focus on the southern coastal flank of Tenerife island, a strategic beach tourism destination of large socioeconomic importance. To this end, experimental and simulated data of winds and waves are used to study the severity, seasonality, and directionality of wave storms with considerable potential to cause significant impact on beaches. Furthermore, tidal experimental records are employed to test the joint occurrence of wave storms and significantly high sea levels. Long-term statistical analysis of extreme wave storms at different locations reveals a complex spatial pattern of wave storminess around the islands and in the southern flank of Tenerife, due to the intricacy of the coastline geometry, the presence of deep channels between islands, the high altitude and complex topography of the islands, and the sheltering effects exerted by each island over the others, depending on the directionality of the incident wave fields. In particular, south of Tenerife, the energy content and directionality of wave storms show substantial spatial variability, while the timing of extreme wave storms throughout the year exhibits a marked seasonal character. A specific extreme storm is examined in detail, as an illustrative case study of severe beach erosion and infrastructure damage.
Identifying 3000-Year Old Human Interaction Spheres in Central Fiji through Lapita Ceramic Sand-Temper Analyses
Authors: Kumar Roselyn , Nunn Patrick D. , Nakoro Elia
Published: June 2021

Petrographic analyses of sand tempers in Pacific Island potsherds reveal information about ancient human interactions within archipelagic contexts. By comparison with bedrock mineralogy, analyses of 45 sherds from the Lapita settlement at Naitabale on Moturiki Island (central Fiji) show that most sherds were manufactured locally but that a minority is exotic. Using ternary plots of LF-QF-FM (LF—lithic fragments; QF—quartz + feldspar; FM—ferromagnesian), it is shown that exotic material (either pots or temper sands) most likely came from elsewhere in Fiji, probably southeast Viti Levu Island, central Lau, Lomaiviti and Kadavu. Geoscientific analyses of archaeological samples therefore gives us insights into how people likely interacted within the Fiji Archipelago three millennia ago.
An Exploratory Study of Geospace Perturbations Using Financial Analysis Tools in the Context of Complex Systems
Authors: Zitis Pavlos I. , Potirakis Stelios M. , Balasis Georgios , Eftaxias Konstantinos
Published: June 2021

In the frame of complex systems research, methods used to quantitatively analyze specific dynamic phenomena are often used to analyze phenomena from other disciplines on the grounds that are governed by similar dynamics. Technical analysis is considered the oldest, currently omnipresent, method for financial markets analysis, which uses past prices aiming at the possible short-term forecast of future prices. This work is the first attempt to explore the applicability of technical analysis tools on disturbance storm time (Dst) index time series, aiming at the identification of similar features between the Dst time series during magnetic storms (MSs) and asset price time series. We employ the following financial analysis tools: simple moving average (SMA), Bollinger bands, and relative strength index (RSI), formulating an analysis approach based on various features, appearing in financial time series during high volatility periods, that could be found during the different phases of the evolution of an MS (onset, main development, and recovery phase), focusing on the temporal sequence they occur. The applicability of the proposed analysis approach is examined on several MS events and the results reveal similar behavior with the financial time series in high volatility periods. We postulate that these specialized data analysis methods could be combined in the future with other statistical and complex systems time series analysis methods in order to form a useful toolbox for the study of geospace perturbations related to natural hazards.
Impact of Selected Geriatric Syndromes on the Quality of Life in the Population Aged 60 and Older
Authors: Doležalová Jitka , Tóthová Valérie , Neugebauer Jan , Sadílek Petr
Published: June 2021

Background: Geriatric syndromes represent a critical domain in the population more than 60 years old. Basic syndromes include frailty, sarcopenia, loss of body mass, and a mild cognitive disorder. These are significant problems which can affect the quality of life. In our study, the Rapid Geriatric Assessment (RGA) tool was used to assess the geriatric syndromes, and the WHOQOL-BREF was used to assess the quality of life to survey 498 respondents from a population aged 60 and older. In all the assessments, the distribution of variables was tested, a nonnormal distribution of variables was identified, and subsequently, nonparametric tests were performed to identify the differences between groups. The study showed that the domain of physical health and the psychological domain were most affected. The results have shown that individual geriatric syndromes affect certain domains of the quality of life of the population above 60 with various intensity.
Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
Authors: Nassim Marouane , Park Haley , Dikaios Elena , Potes Angela , Elbaz Sasha , Mc Veigh Clare , Lipman Mark , Novak Marta , Trinh Emilie , Alam Ahsan , Suri Rita S. , Thomas Zoe , Torres-Platas Susana , Vasudev Akshya , Sasi Neeti , Gautier Maryse , Mucsi Istvan , Noble Helen , Rej Soham
Published: June 2021

Background: Between 20–50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based interventions can improve depression and anxiety symptoms in patients receiving this treatment. Methods: We conducted an 8-week multicenter randomized controlled trial comparing a brief mindfulness intervention (BMI) vs. an active control (Health Enhancement Program [HEP]) in 55 patients receiving dialysis with symptoms of depression and/or anxiety. The primary outcome was change in Patient Health Questionnaire-9 (PHQ-9) depression scores, with a primary analysis in participants with baseline PHQ-9 ≥ 10, and a secondary analysis including all participants. The secondary outcome was change in Generalized Anxiety Disorder-7 (GAD-7) anxiety scores with corresponding primary and secondary analyses. Results: Both BMI and HEP reduced depressive symptoms, with no difference between trial arms (PHQ-9 change = −7.0 vs. −6.1, p = 0.62). BMI was more effective than HEP in reducing anxiety (GAD-7 change = −8.7 vs. −1.4, p = 0.01). Secondary analyses revealed no differences between arms. Conclusions: For patients undergoing dialysis, both BMI and HEP may be helpful interventions for depression symptoms, and BMI may be superior to HEP for anxiety symptoms. Mindfulness-based and other psychosocial interventions may be further evaluated in those undergoing dialysis as treatment options for symptoms of depression and anxiety.
Assessment of Workplace Safety Climate among Healthcare Workers during the COVID-19 Pandemic in Low and Middle Income Countries: A Case Study of Nigeria
Authors: Moda Haruna Musa , Dama Fabian M. , Nwadike Christopher , Alatni Basim S. , Adewoye Solomon O. , Sawyerr Henry , Doka Pauline J. S. , Danjin Mela
Published: June 2021

The COVID-19 pandemic has presented several organizations with the opportunity to review their operational strategies, as well as the existing safety climate within their establishments. The healthcare sector is not an exception, especially those in Low and Middle Income Countries (LMICs), where most safety systems are not robust when compared with developed countries. The study aim is to assess the occupational safety climate among healthcare workers (HCWs) in LMICs using Nigeria as a case study. A cross-sectional study was adopted to measure safety climate perception among professionals working in healthcare establishment during the COVID-19 pandemic using a validated Nordic Safety Climate Questionnaire (NOSACQ-50). At the end of the survey period, 83% (433) of the responses were adjudged to have met the threshold criteria and were used to inform the study outcome. Worker safety commitment within the healthcare facilities (M = 3.01, SD = 0.42) was statistically significantly higher than management safety priority, commitment, and competence (M = 2.91, SD = 0.46), t(130.52), p < 0.001. A significant effect of the management role was found in regards to management safety priority, commitment, and competence (F(1, 406) = 3.99, p = 0.046, η2 = 0.010). On the contrary, the managerial position does not have a significant effect on worker safety commitment (F(1, 417) = 0.59, p = 0.440, η2 = 0.001). The outcome from the study showed that, where there is active promotion of a positive safety climate in healthcare sectors in LMICs, employees are more likely to engage in positive safety behaviour. To help address the identified gaps, there is the need for more effort to be made towards promoting an effective and positive safety climate across the establishment, including management and healthcare worker commitments.
Pragmatic Evaluation of a Health System-Based Employee Weight Management Program
Authors: JaKa Meghan M. , Dinh Jennifer M. , Rivard Rachael L. , Herrmann Stephen D. , Spoonheim Joel , Pronk Nicolaas P. , Ziegenfuss Jeanette Y.
Published: June 2021

Objective: We aimed to evaluate the fidelity and estimate the effectiveness of a novel health system employee weight-management program. Methods: Employees participating in a weight loss program consisting of self-monitoring, health coaching and meal replacements optionally enrolled in the 12-month study. Longitudinal, single-arm analyses were conducted evaluating change over time via survey, claims and programmatic data. Token participation incentives were offered for survey completion. Results: In total, 140 participants enrolled (51.2 ± 9.8 years; BMI = 33.2 ± 6.5 kg/m2; 89.3% female). During 1 year, participants attended 18.0 ± 12.2 coaching appointments and self-reported significant improvements in weight (−8.2 ± 10.5% body weight), BMI (−3.9 ± 6.5 kg/m2), fruit/vegetable intake, home food preparation, added sugar, sugar sweetened beverages and life satisfaction (all p < 0.05). No significant changes were reported in physical activity, weight-related social support, self-efficacy or healthcare utilization (all p > 0.05). Conclusions: The findings from this evaluation establish implementation fidelity. Clinically significant self-reported weight loss, coupled with improvements in many weight-related behaviors, suggest the program is an effective weight management tool when offered as an employee well-being program.
Sociodemographic Correlates of Parental Co-Participation in Digital Media Use and Physical Play of Preschool-Age Children
Authors: Hasanen Elina , Koivukoski Henriikka , Kortelainen Lauri , Vehmas Hanna , Sääkslahti Arja
Published: June 2021

Young children’s digital media use and physical activity have gained attention in recent research. Parental co-participation has a major impact on children’s health consequences. This study addressed a gap in the research by investigating daily parental co-participation in children’s digital media use and physical play, using the family ecological model theoretical framework. The participants in this nationally representative cross-sectional study were 2512 Finnish parents with two- to six-year-old children. Parents completed a questionnaire. Sociodemographic correlates of co-participation and of the awareness of guidelines regarding co-participation and correlation between co-participation in digital media use and physical play were analysed. Parental co-participation in physical play and digital media use correlated positively. Lower parental age, male parental gender, Finnish and Swedish languages, a fewer number of children, and a male child gender were associated with more co-participation in one or both activities, and parental female gender and low family income were associated with more awareness. The awareness of guidelines was not associated with co-participation in digital media use. There were sociodemographic differences in parental co-participation. From a health counselling perspective, parents may benefit from national recommendations on digital media use and physical activity, but adherence to guidelines depends on the family context.
Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides
Authors: Martin-Reina Jose , Casanova Alfredo G. , Dahiri Bouchra , Fernández Isaías , Fernández-Palacín Ana , Bautista Juan , Morales Ana I. , Moreno Isabel
Published: June 2021

Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase and butyrylcholinesterase activities are considered as biomarkers of pesticides poisoning. However, biomarkers of oxidative stress are also playing an important role in toxicity of these contaminants. Further, increased activities of gamma-glutamyltransferase, alanine aminotransferase, urea and creatinine have been linked with hepatic and nephrotoxic cell damage, respectively. The aim of this study was to ascertain if the indirect exposure to pesticides leads to some biochemical parameter changes. Thus, cholinesterase activities, oxidative stress status (lipid and protein oxidation), hepatic function (AST and ALT levels), hormonal function (TSH, T4, FSH, LH and AMH), renal function (serum creatinine and urea), as well as possible subclinical kidney damage (urinary proteins and biomarkers of early kidney damage) were evaluated in farmer women who collect fruits and vegetables comparing with a group of women non-occupational exposed to pesticides but living in the same rural environment. Samples were taken periodically along one year to relate the observed effects to a chronic exposure. Our main results showed for the first time a subclinical kidney damage in a rural setting with indirect chronic exposure to pesticides.
Characteristics and Outcomes of Pediatric COVID-19 Patients in Osaka, Japan
Authors: Katayama Yusuke , Zha Ling , Kitamura Tetsuhisa , Hirayama Atsushi , Takeuchi Taro , Tanaka Kenta , Komukai Sho , Shimazu Takeshi , Sobue Tomotaka ,   on behalf of the COVID-19 Epidemiology Research Group of Osaka University
Published: June 2021

The epidemiological information on characteristics, in-hospital treatments, and outcomes of the coronavirus disease 2019 (COVID-19) among pediatric patients has not been fully evaluated in Japan. This was a retrospective observational study conducted in the Osaka Prefecture, Japan, and we enrolled laboratory-confirmed COVID-19 patients aged ≤ 19 years old from January to November in 2020. Of 14,846 COVID-19 eligible patients, 1240 pediatric patients (8.4%) were registered during the study period; 329 were children aged 0–9 years (26.5%) and 911 were adolescents aged 10–19 years (73.5%). The majority of the patients exhibited mild symptoms at diagnosis (872, 70.3%), some were asymptomatic (296, 23.9%). Cluster infections occurred in child-care facilities (26, 7.9%) among children and in universities (27, 3.0%) and schools (18, 2.0%) among adolescents. The number of close-contact cases was 260 (69.0%) in children and 459 (50.4%) in adolescents. Sixty of the children (18.2%) and 90 of the adolescents (9.9%) were hospitalized. One patient received mechanical ventilation, and none underwent extracorporeal membrane oxygenation. One patient was admitted to the intensive care unit; there were no deaths. These results are useful for recognizing the clinical course from transmission route to outcomes of this infection in pediatric patients.
The Role of Family Influence and Academic Satisfaction on Career Decision-Making Self-Efficacy and Happiness
Authors: Koçak Orhan , Ak Namık , Erdem Sezer Seçkin , Sinan Mehmet , Younis Mustafa Z. , Erdoğan Abdullah
Published: June 2021

Careers are a reality of life that need to be considered as multi-dimensional in today’s modern societies. Choosing a career is a complex process that coincides with high school and university ages, creating psycho-social stress. Considering the literature, the effects of different environmental factors have been revealed in separate studies. This study examines both individual and environmental factors together. By adopting a quantitative research method, we collected cross-sectional data through online questionnaires from 1130 university students. The association of family influence and academic satisfaction with happiness through career decision self-efficacy was meaningful using gender, age, income, and parents’ education as control variables. Family influence and academic satisfaction were positively correlated with career decision self-efficacy and happiness. In conclusion, we found that family influence and support, students’ work, and academic satisfaction are positively significant in terms of the career process and happiness. It was understood that the career reality should be considered with a holistic view that includes family, school, and work experience.