bluuebunny/crossref_metadata_2025 huggingface dataset:
Reporte de caso de necrosis apical en un cultivo de mango (Mangifera indica L.) establecido bajo condiciones del Caribe seco colombiano
Authors: Gómez-Ramírez Luis Fernando , Sierra-Baquero Paola Vanessa , Salgado-Torres Germán Antonio , Rubiano-Rodríguez José Antonio
Published: July 2022

La necrosis apical bacteriana del mango es una enfermedad crítica reportada principalmente en Europa, que se caracteriza por la generación de lesiones necróticas en yemas y hojas, las cuales se extienden a través de los peciolos hacia los tallos. Su incidencia resulta en pérdidas económicas importantes debido a una disminución de la producción. Los agentes causales conocidos de esta enfermedad son las bacterias Pseudomonas syringae y Pantoea spp., que sobreviven como epífitas en la superficie de las plantas.  En un cultivo de mango cv. Keitt de dos años, establecido en la Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA), Centro de Investigación Motilonia, se evidenciaron síntomas de necrosis en yemas, hojas y ramas.  Las plantas de mango se vieron afectadas de forma descendente hasta su muerte a los 30 días después los primeros síntomas. Se tomaron cinco muestras de tejido foliar afectado y pecíolos para aislar el agente causal y generar un diagnóstico a fin de realizar un manejo preciso de la enfermedad. Las muestras se desinfectaron superficialmente y se incubaron en cámara húmeda y medios de cultivo por tres días. Después de la incubación, las hifas, los exudados y las colonias bacterianas se sembraron en medios de cultivo sólidos. Los aislamientos obtenidos se caracterizaron a nivel morfológico y bioquímico. Los resultados arrojaron la presencia de bacterias identificadas como Pantoea spp. por amplificación y secuenciación de la región que codifica para la subunidad 16S del ARNr. Las pruebas de patogenicidad in vitro sugieren preliminarmente a Pantoea spp. como el agente causal de la enfermedad. Este trabajo es el primer reporte de necrosis apical por Pantoea spp. en mango para Colombia.
Associations Between the Severity of Obsessive-Compulsive Disorder and Vocal Features in Children and Adolescents: Protocol for a Statistical and Machine Learning Analysis
Authors: Clemmensen Line Katrine Harder , Lønfeldt Nicole Nadine , Das Sneha , Lund Nicklas Leander , Uhre Valdemar Funch , Mora-Jensen Anna-Rosa Cecilie , Pretzmann Linea , Uhre Camilla Funch , Ritter Melanie , Korsbjerg Nicoline Løcke Jepsen , Hagstrøm Julie , Thoustrup Christine Lykke , Clemmesen Iben Thiemer , Plessen Kersten Jessica , Pagsberg Anne Katrine
Published: July 2022

Background

Artificial intelligence tools have the potential to objectively identify youth in need of mental health care. Speech signals have shown promise as a source for predicting various psychiatric conditions and transdiagnostic symptoms.

Objective

We designed a study testing the association between obsessive-compulsive disorder (OCD) diagnosis and symptom severity on vocal features in children and adolescents. Here, we present an analysis plan and statistical report for the study to document our a priori hypotheses and increase the robustness of the findings of our planned study.

Methods

Audio recordings of clinical interviews of 47 children and adolescents with OCD and 17 children and adolescents without a psychiatric diagnosis will be analyzed. Youths were between 8 and 17 years old. We will test the effect of OCD diagnosis on computationally derived scores of vocal activation using ANOVA. To test the effect of OCD severity classifications on the same computationally derived vocal scores, we will perform a logistic regression. Finally, we will attempt to create an improved indicator of OCD severity by refining the model with more relevant labels. Models will be adjusted for age and gender. Model validation strategies are outlined.

Results

Simulated results are presented. The actual results using real data will be presented in future publications.

Conclusions

A major strength of this study is that we will include age and gender in our models to increase classification accuracy. A major challenge is the suboptimal quality of the audio recordings, which are representative of in-the-wild data and a large body of recordings collected during other clinical trials. This preregistered analysis plan and statistical report will increase the validity of the interpretations of the upcoming results.

International Registered Report Identifier (IRRID)

DERR1-10.2196/39613
Editorial
Authors: Vásquez Harold
Published: July 2022

No precisa de un resumen.
La prevención de riesgos laborales en la gestión empresarial en España: 25 años de la ley 31/1995
Authors: Blanco Silva Fernando , Sarmiento Díez Oriol , Baamonde Rial Antonio
Published: July 2022

La aprobación de la Ley 31/1995 de prevención de riesgos laborales supone un acontecimiento muy importante de esta disciplina en España. Esta fue la primera vez que el Estado Español aprobaba un marco normativo que debían cumplir todas las empresas españolas y la administración pública. La Ley 31/1995 introduce una nueva dimensión en la gestión de las empresas españolas, y desde ese momento todas las empresas y administraciones públicas deben destinar importantes recursos para garantizar la seguridad y salud de sus trabajadores. Esto ha supuesto una mejora general de las condiciones laborales de los trabajadores españoles en los últimos años. En este artículo analizamos las consecuencias de la Ley 31/1995 para las empresas españolas cuando cumplen sus primeros 25 años, el resultado son cambios significativos en la gestión, una reducción del número de accidentes laborales en España y, finalmente, la implantación de una cultura preventiva, que ha sido muy satisfactoria para toda la sociedad española.
Turismo, vaivenes y desigualdad: cómo repercuten las instituciones participativas y de transparencia en la actividad turística y su incidencia en la desigualdad en Latinoamérica (2002-2019)
Authors: Mella Gómez Luis  Eduardo
Published: July 2022

El presente trabajo tiene como finalidad observar la incidencia de la actividad turística en la desigualdad a través de las instituciones participativas y de transparencia, que permiten el acceso a rentas de dicha actividad. Se toma para el análisis diez (10) países de Latinoamérica durante el período de 2002-2019 y se utilizan modelos de datos de panel dinámicos con efectos fijos que corrigen por heterocedasticidad y por sesgo de Nickell, con el fin de observar la dinámica de corto y largo plazo en las variables de interés. Los resultados muestran consistencia con la literatura sobre los efectos mixtos de la actividad turística y la desigualdad en Latinoamérica. Asimismo, añade nueva evidencia sobre dos canales de transmisión por los que la actividad turística impacta en la desigualdad: 1) mediante instituciones participativas que no involucran a grupos vulnerables en la dinámica productiva del sector turismo en el corto plazo y que no generan un efecto redistributivo a largo plazo; y 2) a través de mecanismos de transparencia que no permiten un adecuado control de la corrupción en el sector turismo, tanto a corto como a largo plazo. Esto plantea serios retos en materia de reformas y cambios estructurales necesarios en lo que refiere a mecanismos de participación y de transparencia, para que las decisiones de política pública, especialmente en el sector turismo, estén más a favor del votante medio y de grupos vulnerables.
Rationalization of financial resources at the enterprise
Authors: Konovalova A. A. , Yakimova D. A. , Danilova A. A.
Published: July 2022

The rationalization of financial resources at the enterprise is currently a steadily developing direction of the economic activity of the organization. It implies the need for analytics of the enterprise economy, accounting, financial activities, etc. This direction includes the development of methods for managing the financial resources of the enterprise and their sources. The article discusses various aspects of planning and research of financial resources in the activities of enterprises. The main objective of this article is to consider the basic principles of managing financial costs and their sources in the enterprise. An algorithm for conducting a comprehensive analysis of the financial condition of an enterprise and evaluating the effectiveness of its activities is proposed. As a result of the study, the most common problems in improving the efficiency of managing financial processes in an organization were identified. A recommendation was made to use an integrated method for rationalizing financial resources in order to eliminate unplanned costs. The paper presents the practical application of an integrated method for managing costs in an enterprise.
Lens for matrix photodetector
Authors: Vladimirov V. D. , Gusarov I. E. , Kalugin A. I.
Published: July 2022

The main areas of application of matrix photodetectors are considered. The features of the matrix photodetector device are considered, consisting in the presence of a certain distance between the elements of the photodetector. The principle of formation of blind spots formed on the interelement space in a matrix photodetector is shown. The main methods of reducing the blind spot zone, including the use of methods to increase the resolution, are given. A schematic diagram of image formation by a single-lens optycal system is considered. The disadvantages of such a system are shown, the ratio for calculating the size of blind spots of the optical system is given. An optical scheme of the lens for a matrix photodetector has been developed, which includes raster optical elements and fiber optic cables. The application of the developed scheme for the selected photodetector is considered. A decrease in the blind spots of the photodetector is shown, as well as an increase in its resolution.
Comparison of Different Pipe Materials for Outdoor Water Supply Systems
Authors: Garifyanova L. A. , Mikryukova E. M.
Published: July 2022

The choice of pipes requires professional knowledge, skills to evaluate the properties and features of these products. Ultimately, the choice is not limited only to the selection of the length and diameter of the pipeline, it is also necessary to take into account the physical and mechanical properties, taking into account the period of use of the pipeline system and the negative experience of the past years. Thus, the choice of pipe material becomes a difficult task that requires time. This article summarizes the experience of operating pipes in the outdoor water supply system, describes the main pipe materials and their characteristics, provides recommendations for the installation of pipeline systems and the necessary conditions for reliable transportation. As a result of compliance with the instructions and recommendations of this article, the installation of pipelines will be carried out in accordance with the requirements for outdoor water supply systems established by the current joint venture, SanPiN and GOST. This article is intended to familiarize construction companies specializing in the field of water supply and sanitation.
Analysis of the problems of organizing joint work in Udmurt project companies
Authors: Dunayeva K.V. , Yakushev N.M.
Published: July 2022

The article deals with the problem of organizing collaboration in the design using information modeling technologies. A survey was conducted of specialists developing various sections of the project, on the basis of whose answers diagrams were compiled. Based on the results of the analysis, an assessment of the level of implementation of BIM technologies in the process of organizing collaboration was made. The methods of communication and creation of a Common Data Environment used in Udmurt companies at the moment are also analyzed. The main problems related to the efficiency of the organization of the work of designers are identified, including the lack of experienced specialists and managers in the field of BIM, a low level of elaboration of regulatory documentation, unwillingness or inability to learn and use modern software at the stages of coordination, as well as the lack of experience of Russian companies compared with foreign ones.
Personal qualities as an important component of innovative activity in an enterprise
Authors: Lebedeva E. V. , Klekovkin V. S.
Published: July 2022

The innovative activity of the enterprise directly depends on the innovative activity of the personnel. Currently, many studies have been carried out that describe the innovative activity of an enterprise and its components in various aspects. The staff is the most important part of the innovation process, but its activity is mainly associated with the use of incentive methods. An analysis of maintaining an innovative environment for employees in three world countries shows that the atmosphere that employees need to show their creative potential is not created everywhere. For effective innovative activity of an enterprise, it is necessary to create not only an innovative environment and encourage employees, but also give a significant role to personal qualities. There are several different categories of people who reveal the degree of manifestation of innovative activity. Based on the categories, there is a selection of precisely those employees who have the potential for the formation of innovative activity, which in turn is formed from several stages.
Using artificial intelligence as a companion
Authors: Mukhametgaleeva P. I. , Danilova A. A.
Published: July 2022

The most frequent victims of fraudsters are minors and the elderly. According to VTsIOM statistics for 2020, fraudsters stole a total of about 150 billion rubles. In this regard, there is a need to develop means to protect the home. The paper presents a system that is a model of a smart home system using the capabilities of artificial intelligence and available technologies of today. The paper proposes a system, the principle of which is to obtain information from the outside, which is a model of controlling the functions of a smart house using the capabilities of AI. With the help of devices, the system monitors the state of the house and the well-being of its occupants, and further decision-making depends on the critical situation and the techniques embedded in it. Using the system will be possible through control through voice commands, which will allow you to fully focus on a comfortable and safe spending time in the house. The system functions with the help of "Crosscutting technologies", they are divided into collecting, transmitting/storing and analyzing/deciding.
Method of automation by medicine
Authors: Nasirov R.R. , Chernova A.A.
Published: July 2022

This article describes the groups of possible information systems, which are divided according to their levels of coverage and focus. The possibilities of modern medicine, the use of neural networks in it and the problems in their training, implementation, automation of manual labor in order to speed up processes, reduce the number of errors made and the availability of information for repeated fast reproduction are considered. An exemplary process for passing medical examinations and the advantages of automation are given. Automation allows you to ensure proper control over the quality of service organizations, while identifying the real level of health care performance indicators in general.
Experimental Investigation of Laminated Metal Matrix Composite Used in Drone Frame
Authors: Karthikeyan M.
Published: July 2022

Abstract: In this project design, fabrication, and analysis of sheet laminated Metal Matrix Composites will be carried out. It will be very useful for Aircraft Nose Cone, drone frames, and other surface materials of aircraft. The model of laminated metal matrix composite is designed using Catia V5 and also material to be applied to the body. Imported Geometry from Catia V5 to ANSYS will be analyzed by applying material properties and loads under different conditions. Based on ANSYS results the laminated metal matrix composite will experiment with. In that I take there are three types of Combinations of Laminated Metal Matrix Composites 1) Top and Bottom Aluminum Plate between Carbon fiber (aluminum top 1mm bottom 1mm +carbon 0.5 mm= 2.5mm thickness), 2) Top, Bottom, and Middle Aluminum in between Carbon fiber (aluminum (1+1+1)3mm + carbon 1mm= 4mm thickness), and 3) Top and Bottom Carbon and Middle Aluminum (Carbon (0.5+0.5) 1mm +aluminum 1mm =2mm thickness) which means 25%, 33%, and 50 % of carbon reinforced into aluminum metal.
To Study the Mixing and Compaction Temperatures of Organophilic Nanoclay Modified Asphalt Binder
Authors: Ahmad Ammar , Hafeez Imran
Published: July 2022

Abstract: The use of modified asphalt binders in hot-mix asphalt has steadily increased over the past several decades. Mixing and compaction temperatures of an asphalt binder plays a vital role in the production and placement of asphalt mixes but there are no standards for mixing and compaction temperatures for modified asphalt binder especially with Organophilic nanoclay. In this study the effect of nanoclay modified binder on mixing and compaction temperatures of asphalt mixture was observed using conventional test for asphalt mixture-softening point test, penetration test and rotational viscometer test. Five different percentages i-e 3, 3.5, 4, 4.5 and 5% of Nanoclay (modifier) are selected for three different binders (ARL 60/70, ARL 80/100 & NRL 60/70). Six different samples for each binder are prepared and conventional testing is carried out using standard procedures. With an increase in the percentage of Nanoclay the softening point values and viscosity values increases, similarly the penetration values decrease. The mixing temperature range is 155-165°C and compaction temperature range is 135-145 °C to achieve maximum density in the field
Predicting Covid-19 Misleading Information Using Sentiment Analysis
Authors: B S Mr. Venkatesh Prasad , H S Meghana , M N Nachiketh , S Nishitha , M S Sahana
Published: July 2022

Abstract During the go higher of grouping networking time, there has been a be moving as waves of user produced what is in. Millions of people having the same their ideas daily on microblogging site because of its quality of short and simple way of look. To mine the feeling from a having general approval now microblogging support, twitter, we offer and make observation of an example where user post true tweets about covid-19. By using both corpus based and dictionary based method we may clear an offspring of parts coming from different sorts way in, to come to a decision about the connotation adjustment of the emotion statements in tweets. To make clear the example or picture the use and good effects of the offered system an example learning process is presented
Investigation of Abrasion Test and Mechanical Properties of Concrete Using Fly Ash as A Partial Replacement of Cement
Authors: Tripathi Om , Rawat Vishal , Mishra Abhishek , Vanshaj Kumar
Published: July 2022

Abstract: Concrete is one of the most versatile and widely used material in the construction sector. With the development and advancements of concrete, Civil engineering has reached its technological pinnacle. Despite its global and excessive demands, the consumption of cement is increasing day by day which is to be managed. Also there are many challenges related to its consistent strength performance , Abrasion resistance, Durability etc. so there is a great need to overcome these problems by the application of a pozzolanic admixture known as Fly ash which is responsible for improving various mechanical properties of concrete such as Abrasion Resistance and strength aspects and also reducing the consumption of cement at the same time. In this experimental Work, the Inclusion of Fly Ash and its effect on the various mechanical properties of the concrete i.e. Abrasion resistance, compressive strength, split tensile strength and flexural strength etc is investigated. The present investigation is carried on M35 Grade concrete. Firstly, concrete mixes is prepared by using Ordinary Portland cement( OPC 53) as a reference concrete mix and then blended concrete mixes is prepared by partial replacement of cement using fly ash in range of 10%, 20%, 30%, 40%, 45% by the weight of cement. This experimental study is carried for Determining the differences in the various mechanical properties of blended concrete (Fly ash and cement) and conventional concrete. The optimum percentage of using fly ash with cement in the concrete mixes is determined. The various parameters studies of concrete investigated are Abrasion resistance , workability of freshly prepared concrete mixes, compressive strength at 7 and 28 days, split tensile strength at 28 days. All these tests on concrete mixes is to be performed for both conventional concrete mixes (using only OPC) and also with blended concrete mixes ( OPC and its partial replacements with fly ash).
Effect of Manufactured Sand with Steel Fibre and Polypropylene on Strength Properties of Concrete
Authors: Yadav Ashish Kumar , Rawat Vishal , Vanshaj Kumar , Mishra Abhishek
Published: July 2022

Abstract: The scarcity of natural sand necessitates the use of alternate materials to replace it. This experiment investigates manufactured sand, a readily sourced industrial by - products waste material in India, as an alternative to natural sand, which is traditionally utilized as fine aggregate in concrete construction. In this present work the attempt has been made to study the effect of manufactured sand by partially replacing fine aggregate in concrete with addition of steel fibre and also polypropylene fibre separately. Strength properties such as compressive (7& 28 days) and tensile strength (28 days) along with fresh concrete properties; workability is determined. This test carried on referral concrete of grade M35; the concrete mixes were made using Portland pozzolana cement, and also replacing fine aggregate by 15, 30, 45, 60 and 75 percent of manufactured sand. After optimization of percentage replacement of fine aggregate by M-sand, further we made concrete Mixes using steel fibres at rate of 0.50, 0.75, 1 and 1.25 percent and also concrete mixes were made with polypropylene fibre at rate of 0.5kg/m 3 , 1kg/m3 , 1.5kg/m3 , 2 kg/m3 and various mechanical properties were investigated. The result concluded that M-sand is suitably replace the natural river sand at optimum limit and addition of fibre reinforcement also improves the compressive, flexural and tensile strength of concrete specimens however addition of polypropylene fibre and steel adversely affect the workability.
Resistive Ladder Network in Handle Bar Switch Assembly
Authors: Chaudhary Ashish , Singh Dinesh
Published: July 2022

Abstract: An switching interface of handle bar assembly LH-RH, where it comprise a switching network have a input terminal Coupled with an input voltage supply, an output terminal. The interface network comprises of series of resistance having a predertmined values,i.e each of switches present on handle bar LH as well as in RH are coupled in between input & output terminal which are used to evaluate a particular voltage value band when it get connect with 12 V voltage DC source . The switching interface further comprising or include a controller which gets input from the output terminal of interface Network when any of the switch is closed.After evaluating the total resistance at output terminal across interface (When any of switch is pressed) comparing the output Voltage with the supplied one .we can evaluate the voltage Ratio which reprents which button is pressed.
Water Saving Tweety
Authors: Roy Mr. Debabrata
Published: July 2022

Abstract: It is often seen that a lot of water is wasted from the water pipes, constructed by the municipality at the street corners. In some cases, this is due to the unawareness of people, not turning off the water tap, or an internal dis- turbance in the tap. The above factors motivate us to develop a solution so that water wastage can be reduced which helps to save the drinking water in this country. The main purpose of this project is to first find out if there is a container or bucket below the water tap for getting water. If there is no such thing and the water tap is open for no reason, then it will send a notification to the mobile number of the ward counselor or owner of the water tap so that she/he can take some immediate steps. Whenever that kind of situation occurs, the module will also broadcast an audio message., so that anyone who passes by in front of the water tap can also take some immediate actions. Also, if someone tries to steal it, the module will also warn the ward counselor by sending an Alert SMS.
Impact Of Specific And Macroeconomic Variables On Islamic Stock Price
Authors: Silfia Aida Bela , Zuhroh Idah
Published: July 2022

This study aims to analyze the effect of fundamental variables and macroeconomic variables on sharia stock prices in the Jakarta Islamic Index (JII) for 1 periode 20116-2020 which publishes financial statements successively. The analytical method used is panel data regression with Common Effect Model (CEM) research model and assisted by the Eviews 9 program. The partial results show that all variables have a significant effect on Sharia Stock Prices except the Earning Per Share (EPS) variable has no effect significant to the Sharia Share Price. While the results of the study simultaneously all variables have a significant influence on the islamic stock price.
Influence of Micronutrients in The Alleviation of Immunotoxicity Induced by Poly Aromatic Hydrocarbons Naphthalene and Anthracene
Authors: M Sreepriya , V Joshi , C Sudha , B Muthukumaran
Published: July 2022

Diet plays a major role in fine tuning the immune system and to combat against dreadful diseases and infections. Micronutrients form an important part of balanced diet and enable efficient functioning of the immune system. Vitamins, minerals and trace elements comprise the major category of micronutrients. Deficiency of micronutrients could culminate in suppression of both adaptive and innate immunity leading to altered immune homeostasis. Anthracene and naphthalene are two environmental pollutants which are highly toxic, carcinogenic poly cyclic aromatic hydrocarbons that gains entry in to the human system through multiple modes. The aim of the current study is to evaluate the potential of four dietary micronutrients Vitamin A, Vitamin C, Folic acid and Zinc to counteract the immunotoxic effects of naphthalene and anthracene on Murine macrophage cell line RAW 264.7. Several cell based assays like MTT assay, LDH leakage assay, Crystal violet test, DCFDA analysis (for ROS generation) and Rhodamine B assay (for measurement of mitochondrial membrane potential) were taken as end point indicators to support the findings of the study. The results showed that, both naphthalene and anthracene triggered the production of ROS, altered mitochondrial membrane potential, and induced strong immunosuppressive effects. The immunosuppressive effect was found to be more prevalent in anthracene treated cells. Pre-treatment with the micronutrients exhibited considerable protection against naphthalene and anthracene induced changes in the cells primarily through the antioxidant and immunomodulatory effects. The overall protective effects offered against naphthalene and anthracene was found to be superior in the Vitamin A treated cells as compared Vitamin C, Folic acid and Zinc treated cells. Prolonged immunosuppression reduces immune surveillance and hence could activate oncogenic signals leading to carcinogenic conditions. Regular micronutrient supplementation in the diet could help considerably to negate or prevent these deleterious conditions.
Protective Effect ofEthanolic Extract ofArgyreia Nervosa Leaves on Chronic-Diabetes Induced Testicular Alterations
Authors: Arunagiri Saranya , Srinivasan  , Maheshwari
Published: July 2022

Our objective is to evaluated the role of primary phytochemical constituents present in ethanol extracts of Argyreia nervosa, resulting in chronic diabetic males induced infertility. The current study aims to assess the protective role of ethanol extract of Argyreia Nervosa against Streptozotocin (STZ)caused alterations in blood glucose level and histopathology architectureof the testis. Phytochemical profiling of ethanolicextractArgyreiaNervosa was carried out. The diabetic model was created by giving animals 40 mg/kg/BW of STZ(intraperitoneally). Further, Argyreia nervosa was administered orally after the induction of STZ and confirmed blood glucose levels in experimental subjects. The drug dosage was (200,400 mg/kg/BW) daily for 60 days. Histopathological analysis of the removed testis at specified intervals was carried out. Ethanol extracts contain more phytochemical constituents such as tannins, phenolics, quercetin, saponins, flavonoids, beta carotene, etc. The components have more antioxidant properties when compared with methanol and petroleum ether extract. The results showed that blood glucose levels significantly decreased and noted elevated serum testosterone levels in Argyreia nervosa(400mg/kg) treated groups compared with the untreated Streptozotocin (STZ) induced group. The histopathological study revealed that the Argyreia nervosa (200&400 mg/kg/BW) treated groups show significant changes in testis when compared with the STZ induced diabetic groups. This herbal has many antioxidants, anti-diabetic, anti-microbial, antifungal, and aphrodisiac. Ethanol extract of Argyreia nervosa lowers the blood glucose level in hyperglycemic patients due to its anti-diabetic property and aphrodisiac properties. Like an adaptogenic aphrodisiac, Argyreia nervosa extracts contain potent antioxidants, which enhance sperm density and sperm quality and minimize the damage to sperm cells by scavenging free radicals resulting from excessive oxidative damage.
Evaluation of Antidiabetic Activity of Corchorus trilocularis Linn Plant Extract
Authors: Omer Shaista , Vidyadhara Suryadevara , Sandeep Doppalapudi
Published: July 2022

Diabetes is a major health issue that has been faced by the majority of the population in the world. Extensive research is being carried out towards development of an antidiabetic component. The aim of the present research was to determine the antidiabetic activity of Corchorus trilocularis Linn plant belonging to the Tiliaceae family. The objectives were to evaluate various serum and pancreatic parameters related to evaluation of diabetes. The whole plant was extracted using various solvents. Phytochemical screening was done for the extracts. Antidiabetic activity was determined using Streptozotocin (STZ) induced diabetes model in rats using 200 mg/kg and 400 mg/kg doses of various extracts. Biochemical components like glycosylated hemoglobin (HbA1c), glutathione, creatine kinase (CK) and lactate dehydrogenase (LDH) were estimated for the collected blood samples from rats. The pancreatic tissue was homogenized and the result was subjected for estimation of TBARS (thiobarbituric acid-reactive substances), catalase, superoxide dismutase (SOD) and glutathione (GSH). Phytochemical screening showed presence of carbohydrates, glycosides, alkaloids, triterpenes, phytosterols, tannins, flavonoids, saponins, mucilage and steroids. The chloroform extract at 400 mg/kg dose significantly lowered the levels of HbA1c and restored blood GSH levels. The levels of CK and LDH were increased in diabetic rats. The treatment with chloroform extract (400 mg/kg) for 21 days significantly reduced the levels of CK when compared to diabetic rats. Extent of TBARS formed was significantly higher (p<0.001) in STZ treated group. In chloroform extract (400 mg/kg) treated groups, TBARS levels have significantly decreased (p<0.001). Diabetic rats treated with chloroform extract (400 mg/kg) showed significant increase (p<0.01) in levels of SOD. GSH activity was reduced in pancreatic tissue of diabetic rats, compared to normal animals. These levels were significantly (p<0.01, p<0.001) increased with chloroform extracts (200 mg/kg and 400 mg/kg) treatment. Thus the present study showed the antidiabetic potency of Corchorus trilocularis Linn plant.Â
Design and Characterization of Fluconazole Loaded Nanosponges Containing Topical Gel Preparation
Authors: R. Jadhav Khanderao , Y. Pawar Ashish , S. Sanap Ashwini , P. Rathod Sharayu , S. Malpure Prashant , S. Bachhav Rishikesh
Published: July 2022

The main aim and objective of this research was to develop and evaluate Fluconazole loaded nanosponges and formulate them as suitable topical gels for delivering the drug systemically after topical application. Fluconazole (FLZ) is a potent triazole anti fungistatic drug; topical administration of novel Fluconazole resulted in systemic absorption, for improved therapeutic effect and better dispersibility as compared to conventional topical formulation. Fluconazole (FLZ) nanosponges prepared by using emulsion solvent diffusion method to improve topical permeation. Nanosponges were formulated successfully using ethyl cellulose and Eudragit RS 100 as polymer, polyvinyl alcohol as the surfactant, and dichloromethane as solvent. The optimised batch of fluconazole loaded nanosponges used to prepare topical gel using different concentrations of carbopol gel. The prepared nanosponges were evaluated by various tests like production yield, drug entrapment efficiency, FTIR, particle size, zeta potential, SEM study. The entrapment efficiency and production yield were excellent. Based on the entrapment efficiency and production yield,out of ten formulations batches of nanosponges was evaluated and from that batch F3 was optimised.Optimized batch F3 containing FLZ and EC in the ratio of 1:3 showed optimum physicochemical and release characteristics. The optimised batch F3 of ethyl cellulose shows highest entrapment efficiency as 97.97% and production yield as 93.85% resp. A complex Fourier transform infrared (FTIR) study examines the formation in the nanosponge structure. The nanosponges had particle size in the range of 234.95 to 374.26 nm. The Zeta Potential was strong enough to produce stable formulations. The zeta potential of optimised batch nanosponges was found to be - 25.05. SEM analysis of optimized batch F3 confirms that nanosponges were spherical in size with a porous and smooth surface. The formulated fluconazole topical gel were characterized for pH, actual drug content, viscosity, spreadability, In -Vitro drug release study. The in -vitro drug release showed maximum drug release of topical gel i.e. 88.34% in 8 hours. The present study demonstrates that, an antifungal drug Fluconazole is formulated in the form of nanosponges topical gel for the antifungal activity and can be best suitable approach in novel drug delivery system than conventional gel. Hence it is concluded that above topical gel formulation of fluconazole loaded nanosponges can be used in treatment of fungal infection.
Population genomics reveals the underlying structure of the small pelagic European sardine and suggests low connectivity within Macaronesia
Authors: Fonseca Rute da , Campos Paula , Iglesia Alba Rey de la , Barroso Gustavo , Bergeron Lucie , Nande Manuel , Tuya Fernando , Abidli Sami , Pérez Montse , Riveiro Isabel , Carrera Pablo , Jurado-Ruzafa Alba , Santamaria M Teresa G , Faria Rui , Machado Andre , Fonseca Miguel , Froufe Elsa , Castro L Filipe C
Published: July 2022

The European sardine (Sardina pilchardus, Walbaum 1792) is
indisputably a commercially important species. Previous studies using
uneven sampling or a limited number of makers have presented sometimes
conflicting evidence for the genetic structure of S. pilchardus
populations.  Here we show that whole genome data from 108 individuals
from 16 sampling areas across 5,000 Km of the species’ distribution
range (from the Eastern Mediterranean to the archipelago of Azores)
supports at least three genetic clusters. One includes individuals from
Azores and Madeira, with evidence of substructure separating these two
archipelagos in the Atlantic. Another cluster broadly corresponds to the
center of the distribution including the sampling sites around Iberia,
separated by the Almeria-Oran front from the third cluster that includes
all of the Mediterranean samples, except those from the Alboran Sea.
Individuals from the Canary Islands appear as belonging to the same
ancestral group as those from the Mediterranean. This suggests at least
two important geographical barriers to gene flow, even though these do
not seem complete, with many individuals from around Iberia and the
Mediterranean showing some patterns compatible with admixture with other
genetic clusters. Genomic regions corresponding to the top outliers of
genetic differentiation are located in areas of low recombination
indicative that genetic architecture also has a role in shaping
population structure. These regions include genes related to otolith
formation, a calcium carbonate structure in the inner ear previously
used to distinguish S. pilchardus populations.  Our results
provide a baseline for further characterization of physical and genetic
barriers that divide European sardine populations, and information for
transnational stock management of this highly exploited species towards
sustainable fisheries.
A continental-scale survey of Wolbachia infections in blue butterflies reveals evidence of interspecific transfer and invasion dynamics
Authors: Shastry Vivaswat , Bell Katherine , Buerkle C. Alex , Fordyce James , Forister Matthew , Gompert Zachariah , Lebeis Sarah , Lucas Lauren , Marion Zach , Nice Chris
Published: July 2022

Infections by maternally inherited bacterial endosymbionts, especially
Wolbachia, are common in insects and other invertebrates but
infection dynamics across species ranges are largely under studied.
Specifically, we lack a broad understanding of the origin of
Wolbachia infections in novel hosts and the factors governing
their spread. We used Genotype-by-Sequencing (GBS) data from previous
population genomics studies for range-wide surveys of Wolbachia
presence and genetic diversity in over 2,700 North American butterflies
of the genus Lycaeides. As few as one sequence read identified by
assembly to a Wolbachia pan-reference genome provided high
accuracy in detecting infections as determined by confirmatory PCR
tests. Using a conservative threshold of five reads, we detected
Wolbachia in all but two of the 107 sampling localities spanning
the continent, and with most localities having high infection
frequencies (mean = 91\% infection rate). Three major
lineages of Wolbachia were identified as separate strains that
appear to represent three separate invasions of Lycaeides
butterflies. Overall, we found extensive evidence for acquisition of
Wolbachia through interspecific transfer between host lineages.
Strain wLycC was confined to a single butterfly taxon, hybrid
lineages derived from it, and closely adjacent populations in other
taxa. While the other two strains were detected throughout the rest of
the continent, strain wLycB almost always co-occurred with
wLycA. Our demographic modeling suggests wLycB is a recent
invasion. These results demonstrate the utility of using resequencing
data from hosts to quantify Wolbachia genetic variation and
provide evidence of multiple colonizations of novel hosts through
hybridization between butterfly lineages and complex dynamics between
Wolbachia strains.
NEGATIVE WOUND THERAPY WITH INSTALLATION DWELL: CLINICAL RESULTS IN CLEANING AND EXTRACTION OF INFECTIOUS MATERIAL WITH NOVEL
Authors: Saleem Kiran , javed Mayia , Ali Maria , Shahid Yumna , Jabbar Samra
Published: July 2022

The experience involves the use of a new foam dressing in conjunction
with negative pressure wound therapy (NPWTi-D) to remove and cleanse
infectious material from the wound. This paper evaluates the clinical
results of patients who received VERAFLO treatment and dressing. The use
of the innovative foam dressing to facilitate the evacuation of the
infectious, viscous, and scabby material is regarded as a very novel and
beneficial technique. According to studies, the success of the wound
healing process depends not only on the features of the patient, but
also on those of the wound. Expected healing with NPWTi is deemed
fortunate because it guarantees that the damage has reached granulation
and is, therefore, ready to be treated. Again, healthcare facilities
must educate their staff on the significance of NPWTi in the operating
room. VERAFLO CLEANSE CHOICE has consistently demonstrated its efficacy
in eliminating infectious particles and exudate, ensuring the effective
treatment of wounds. In conclusion, the approach is deemed effective
since it reduces hospital mortality and length of stay and communicates
the intricacies of injuries to neurosurgeons in order to choose the
appropriate treatment procedures.

This article evaluates the study’s methodology, findings,
pathophysiology, biochemistry, genetics, scientific analysis, clinical
implications, and unanswered questions concerning the removal and
cleansing of infectious material from a wound using a novel technique
that combines negative pressure therapy with instillation.
Calculation of mass transfer limitations for a gas-phase reaction in an isothermal fixed bed reactor: A tutorial
Authors: García-Sánchez Julieth , Valderrama-Zapata Rodrigo , Acevedo-Córdoba Luisa , Rincón-Ortiz Sergio , Baldovino-Medrano Víctor
Published: July 2022

The study of the reactivity of catalysts requires assessing chemical
kinetics and mechanism in the absence of mass transport artifacts.
Despite the existence of models and criteria for assessing the presence
of mass transfer limitations during catalytic tests for gas-phase
reactions in isothermal fixed bed reactors, the literature does not
present straightforward protocols for performing the latter
calculations. In this work, we present a systematic protocol for the
calculations above. Particularly, the effectiveness factor for external
and the Weisz-Prater number for the internal mass transfer limitations
were developed. The oxidation of propane over mixed vanadium-aluminum
(hydr)oxides was taken as a case study. Based on these protocols we
perform a sensitivity study of the models. Results showed that the model
for calculating the effectiveness factor was poorly sensitive to all the
above modifications. Meanwhile, the Weisz-Prater number was much more
sensitive to the studied modifications, even reaching deviations up to
~200%.
Uncovering Cultural Capital in Indonesia’s Underground Music Scene: A Discourse
Authors: Surya Permana Catur
Published: July 2022

Underground music is considered to have a very strong context in terms of cultural capital. By examining the capital and musical concepts of the underground music scene, it is possible to elaborate and explain the collapse of the regime. So that it raises a reaction to freedom in voicing certain class ideologies. The role of music was finally able to represent the voices of the politicized or oppressed people overpowering, one of which occurred in the New Order. Underground music emerged as a cultural capital which Bourdieu called an artifact in dissecting the problems of the social field. The purpose of this research is to uncover the cultural capital possessed by Underground Music which creates views that open the minds and hearts of representatives of certain classes. This research is carried out by reviewing literature, musicology, and historical records of Underground music, which will be presented and dialogued with the concept of Modal theory from Bourdieu and popular music analysis from David Machin. This research tries to answer the image anxiety that emerges from the dark and loud Underground Music Scene but instead has a sacred context in the development of the socio-cultural situation in Indonesia.
The Elicit Function of Speech Acts in Questioning on Investigative Interviews in Criminal Inspection of Dump Truck Theft Cases at Cirebon City Police Station
Authors: Dutha Bachari Andika
Published: July 2022

In this study, the data source was obtained from the transcription of dump truck theft cases recorded in the Police Record. Investigators conducted investigative interviews to obtain information from witnesses and suspects, which led to the suspect's confession. The investigator asked several questions to the examinee regarding the criminal act. The data analysis method was carried out by eliminating the answers being examined and focusing on the questions given by the investigator to be classified based on the seven elicit functions of the speech act of asking questions described by Tsui (2002). It was found that the elicit function in the investigator's question was the function of seeking information (appearing 119 times), repeat function (appear 50 times), clarifying function (appear 47 times), confirm function (appear 43 times), and approve function (appear 11 times). The elicit function that occurred the most from the questions submitted by investigators was the function of seeking information, which was 119 times out of 270 questions. In contrast, the function of asking for commitment was not found.
Keywords: ask, elicit function, investigative interview speech act
Real-Time Big Data Analytics for Data Stream Challenges: An Overview
Authors: Hassan Alaa Abdelraheem , Hassan Tarig Mohammed
Published: July 2022

The conventional approach of evaluating massive data is inappropriate for real-time analysis; therefore, analysing big data in a data stream remains a critical issue for numerous applications. It is critical in real-time big data analytics to process data at the point where they are arriving at a quick reaction and good decision making, necessitating the development of a novel architecture that allows for real-time processing at high speed and low latency. Processing and anlayzing a data stream in real-time is critical for a variety of applications; however, handling a large amount of data from a variety of sources, such as sensor networks, web traffic, social media, video streams, and other sources, is a considerable difficulty. The main goal of this paper is to give an overview of the current architecture for real time big data analytics, real-time data stream processing methods available, including their system architectures Lambda, kappa, and delta large data stream processing.
Coastal Environmental Impact of Geohazards in the Area of the Habibas Islands (Western Algeria, Alboran): Insights from GIS-Analysis and Remote Sensing
Authors: Amir Lübna , Theilen-Willige Barbara
Published: July 2022

Algerian coastal areas in the southern part of the western Mediterranean Sea are prone to geohazards such as tsunami waves, storm surges, earthquakes, submarine mass movements, and volcanism. Located in the Gulf of Oran, the Habibas Archipelago is a well-preserved bio-environment where fauna and flora are unique. This region is nevertheless a zone where marine traffic (oil) and oil ports pose a threat to environmental offshore pollution. This study is focused on submarine mass movements and their potential to cause local tsunami waves. Digital Elevation Model (DEM) data and the DEM-derived morphometric maps support these investigations being integrated into a GeoInformation System (GIS). Bathymetric data of the western Mediterranean Sea are used to derive causal factors that influence the susceptibility to submarine mass movements. Sentinel 2, Landsat 8, and Sentinel 1 radar images help to identify coastal areas prone to landslides and the coast-near structural pattern. By integrating data collected from the literature and maps (geology, tectonics, earthquakes, mass movements) into a GeoInformationSystem (GIS) and by using remote sensing analysis, it might be possible to derive more precisely in the case of submarine landslides and turbidity currents in the which direction potential tsunami waves caused by these mass movements might be focused and directed.