bluuebunny/crossref_metadata_2025 huggingface dataset:
Problems of organizing the work of departments of correctional orphanages for juvenile delinquents at the monasteries of the Stavropol and Yekaterinodar diocese in the late XIX – early XX centuries
Authors:   Stavropol State Pedagogical Institute, Nemashkalov P. G. , Volodkova E. N. ,   Stavropol State Pedagogical Institute
Published: June 2024

Introduction. At the present stage of development, society faces the problems in the field of high levels of juvenile delinquency and adolescent deviation, which were typical of Russia at the beginning of the 20th century. In the practice of criminal and penal legislation, the application of imprisonment to them often remains the only form of punishment. As part of the search for an optimal model for achieving a corrective effect, it is interesting to refer to the existing historical experience. A comprehensive inclusion of the public to solve the situation was one of the forms of combating juvenile delinquency since the second half of the 19th century. One of the instruments of state policy in this area was the active involvement of the monasteries of the Russian Orthodox Church, which were to become the leading body in the fight against and prevention in the field of juvenile delinquency. Materials and methods. By the example of the organization of the work of correctional shelters, founded in 1898 at the monasteries of the Kuban region, the authors analyze their activities, the difficulties in organizing work with the contingent within the monasteries of the entire Caucasian department. The conclusion becomes relevant that success in the activities of prevention and correction was possible only with the wide involvement of the public, the training of pupils of shelters in professions that are in demand on the labor market, a combination of various programs and religious educational practices, in close cooperation with the executive authorities of the region. Analysis. An appeal to the history of correctional institutions in the North Caucasus can help improve the organization of work in relation to juveniles who committed crimes in the implementation of the strategy for the execution of punishments. Results. As the results of the study showed, this experiment did not receive wide support not only in the region, but throughout the empire. And only thanks to the help of the public in organizing the work and maintenance of the orphans, with limited funding from the state, the monasteries managed to establish the process of rehabilitation of juvenile delinquents. In combination with the use of various educational systems and programs, school and labor training, various methods of education and mentoring, the monasteries contributed to the correction of minors.
Pengaruh Faktor-Faktor Kepuasan Kerja Terhadap Kinerja Dosen PTS di Bogor
Authors: Pratomo Anton Widio , Fitriyah Idah , Gendalasari Gen Gen
Published: June 2024

The purpose of this study was to test and analyze the effect of job satisfaction factors consisting of the work itself (X1), salary (X2), promotion opportunities (X3), supervision (X4) and co-workers (X5) on lecturer performance and the influence of variables X1, X2, X3, X4 & X5 simultaneously on lecturer performance. This study uses primary data through a survey of as many private university permanent lecturers (PTS) in Bogor. The collected data was processed and analyzed using SPSS software. From the results of this study indicate that; (1) work has a positive and significant effect on the performance of permanent lecturers at PTS in Bogor; (2) salary has no effect on the performance of permanent lecturers at PTS in Bogor; ; (3) promotion opportunities have no effect on the performance of permanent lecturers at PTS in Bogor; (4) supervisors have a positive and significant effect on the performance of permanent lecturers at PTS in Bogor; (5) colleagues have a positive and significant effect on the performance of permanent lecturers at PTS in Bogor; (6) variable X (factors of job satisfaction) as a whole is positive and significant to the performance of PTS lecturers in Bogor by 50.1%
 
Keywords: work, supervision, colleagues, performance
Tactics of Treatment of Tourniquet Syndrome after Gunshot Wounds
Authors: Khoroshun E.M. , Strafun S.S. , Shypilov S.A. , Klapchuk Yu.V. , Bahrii O.S. , Honcharenko S.S. , Kupriianchuk V.V.
Published: June 2024

Summary. The objective of our study was to develop a differentiated approach to the treatment of tourniquet syndrome based on the severity and stages of its development. The work was based on a retrospective analysis of 30 wounded with tourniquet syndrome of the upper and lower extremities, who were treated at the Military Medical Clinical Center of the Northern Region. All the wounded were hospitalized from the combat zone; all were males, aged 33.8±0.4 years. After admission to the Military Medical Center of the Northern Region (Role 3), anamnestic data were collected, clinical symptoms as well as laboratory and additional research methods were analyzed. To form a differentiated approach to the treatment of tourniquet syndrome, the analysis of the following indicators was carried out: the duration of the tourniquet (up to 3 hours, 3.1-6 hours, 6.1 hours and more), the place of tourniquet application (shoulder, thigh), local clinical manifestations (edema, paresthesia, hypoesthesia, anesthesia, hypothermia, contracture of the joints of the hand or foot), laboratory indices (creatinine, alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, potassium, and myoglobin), assessment of peripheral pulse, diuresis, ultrasound examination of muscles, ultrasound examination of the kidneys and inferior vena cava to calculate infusion therapy, radiographic and thermal imaging studies at the site of injury, and intraoperative visual evaluation of the muscles (viable muscles, partial or widespread rhabdomyolysis). Based on the analysis of the obtained data, a classification and treatment algorithm of tourniquet syndrome were developed, which enabled to take a rational approach to the treatment of this category of patients based on determining the severity and stages of its development.
Perancangan Brand Campaign dan Media Promosi Instagram untuk Meningkatkan Awareness Brand Scentella
Authors: Leticia Charissa belle
Published: June 2024

Penelitian ini bertujuan untuk mengenalkan brand Scentella kepada khalayak pasar menggunakan Brand Campaign dan penggunaan media sosial Instagram sebagai sarana promosi. Scentella merupakan sebuah merek lilin aromaterapi yang berbasis di Surabaya yang menjual lilin dengan bahan dasar alami. Metode penelitian yang digunakan adalah deskriptif kualitatif dan subjeknya adalah pengikut Scentella di Instagram. Penggunaan media Instagram sebagai media promosi merupakan hal yang tepat di jaman sekarang. Nilai dari brand Scentella dapat tersampaikan kepada khalayak pasar melalui media sosial Instagram. Gaya desain yang digunakan oleh Scentella merupakan Scandinavian baik dari pemilihan warna maupun penerapan desain untuk media promosi. Diharapkan akan ada awareness yang meningkat dengan adanya kampanye yang diterapkan oleh Scentella.
Legislative initiatives in the field of pest control in Ukraine
Authors: Yarovyi Kyrylo
Published: June 2024

Problem setting. The pace of global trade growth, advancements in innovative technologies, and changes in consumer preferences pose new challenges to contemporary society in ensuring the quality and safety of food products. Analysis of recent researches and publications. The following Ukrainian scholars were interested in ensuring the safety of food products: D. Bernytska, V. Bozhkova, I. Dukhnovsky, A. Luzhetskyi, Y. Myroshnichenko, L. Nosonova, T. Podbereznyak, O Rybak, D. Saulyak, O. Tur, O. Shapurova. Purpose of the research is analysis the current legislation of Ukraine in the field of pest control to ensure the lawful use of pesticides, compliance with ecological balance, and identification of factors affecting the quality of products and the health of consumers. Article’s main body. The article provides a comprehensive analysis of legislative initiatives in the field of pest control in Ukraine. The author meticulously examines aspects of licensing and establishing requirements for pest control services. The definition of the term «pest control» is disclosed, emphasizing its essence as a system of organizational measures aimed at ensuring consumers with quality and safe food resources. Special attention is given to the implementation of the Hazard Analysis and Critical Control Points (HACCP) system to ensure the safety of food resources in Ukraine. Key provisions of legislation focused on ensuring safety and control over pests are highlighted. The article sheds light on key aspects of state regulation of pest control, identifies gaps in legislation, and provides authorial suggestions for their elimination. Additionally, the essence of the HACCP system is elucidated, exploring its legislative aspects related to licensing and setting requirements in the field of pest control. Important aspects of improving legislation and practical aspects of the HACCP system to ensure the safety of food products are discussed. From a legal perspective, HACCP is defined as a system for analyzing hazards and critical control points, overseeing the safety of food products at all stages of production and distribution, with a particular focus on critical control points where risky situations may arise. Conclusions and prospects for the development. The research results lead to the conclusion that pest control is a system of organizational measures aimed at achieving the goal of reducing the number of problematic biological species (pests) to their complete elimination in a specific area, with the aim of reducing all possible risks, such as moral, economic loss, harm to human health, domestic animals, cultivated plants, wild flora, etc. The study establishes the need for harmonizing existing legislation to ensure effective pest control management in Ukraine under the specified conditions.
Propuesta educativa para abordar factores internos y externos limitantes del acceso al crédito financiero en empresas lideradas por mujeres, Cajamarca, Perú
Authors: Tarrillo  Saldaña Oscar , Salcedo-Davalos1 Rosa Amable , Mejía-Huamán Jhonner , Dávila-Mego José Stalin , Sánchez-Chávez Arnaldo , Idrogo-Gálvez Milord , Cabrera-Cabrera Olegario Heiner
Published: June 2024

Accessibility to financial credit for women-led enterprises is influenced by a set of internal and external factors. In this context, the principal objective of the study is to develop a educational proposal to address the internal and external factors limiting access to financial credit in companies led by women in Cajamarca, Peru. The study was non-experimental, transversal, of a basic type. The sample comprised 377 companies, the sampling was non-probabilistic for convenience and the technique was the survey. The results reflect the existence of predominant internal factors such as the lack of credit history (70%), the lack of documentation and required information (65%), the high levels of debt (65%) and the lack of financial education to access financing (60%); and, regarding external factors, the most predominant are the excess of requirements (84%), costs associated with maintaining an account (79%) and distrust in the financial system (62%) that make it difficult to take out financial credit. Ultimately, women entrepreneurs in Cajamarca face both internal and external obstacles that negatively impact their ability to access financing. Given this situation, a specific proposal has been developed aimed at overcoming these limitations.
Satisfacción de Stakeholders Internos en Organizaciones de Educación Superior para su Planificación Estratégica. Caso Universidad Técnica de Cotopaxi
Authors: Erazo Calvopiña Rina Monserrat , Barrera Castro Mario Javier , Salazar Sánchez Indira Salomé , Fernández Rodríguez Sheyla Israela , Montalvan Fernández Anabell Stefania
Published: June 2024

Este análisis es sobre la satisfacción de los Stakeholders internos (estudiantes) en organizaciones de educación superior como pilar fundamental para la orientación de los objetivos estratégicos en organizaciones de educación superior, como estudio de caso, se toma a la Universidad Técnica de Cotopaxi de la ciudad de Latacunga en Ecuador. Se identificó un estudio longitudinal realizado en el presente año (2020) acerca de la satisfacción de los Stakeholders como parte de la complejidad de la Universidad Técnica de Cotopaxi para proponer sus resultados en su Plan Estratégico de Desarrollo Institucional.
Cinco Tipos de Poda en Arándano (Vaccinium Corymbosum L. Cv. Biloxi) y su Influencia en Determinados Parámetros Productivos
Authors: Maticorena Quispe Miguel Francisco , Escobedo Álvarez Jorge Alberto
Published: June 2024

Se realizó un experimento durante la temporada 2015/2016 en una instalación comercial de arándanos (Vaccinium corymbosum) cv. Biloxi de dos años en Chao, Perú, manejada para que el ciclo fenológico anual se inicie con la floración en el mes de abril y culmine con la mayor cosecha entre los meses de agosto y noviembre. El objetivo fue determinar los efectos de la eliminación de flores y frutos y tres tipos de poda aplicados antes del inicio de campaña sobre el rendimiento y la calidad de fruta. Los tratamientos fueron los siguientes: (a) T0: testigo no podado, (b) T1: eliminación mensual (en febrero y marzo) de flores y frutos fuera de época, (c) T2: poda alta - todos los brotes podados a 60 cm del nacimiento de la planta (d) T3: poda baja - todos los brotes podados a 30 cm, (e) T4: poda alta con “alimentadores” (ramas que no fueron podadas, una por planta), (f) T5: poda baja con “alimentadores”. Se demostró que, bajo las condiciones del experimento, la severidad de la poda redujo el Rendimiento. La poda alta aumentó el Calibre Total y el Calibre Comercial de las bayas, y el Porcentaje de Fruta Exportable. No hubo diferencias significativas entre los Porcentajes de Sólidos Solubles frente a la poda. Las plantas con alimentadores mostraron valores intermedios entre el testigo y las plantas podadas, salvo en la variable Rendimiento total. Hace falta mayor investigación en este cultivo bajo condiciones del país para mejorar la productividad.
Comercio Electrónico y su Incidencia en el Impuesto a la Renta
Authors: Moreano Guerra Grace Lilian , Guerrero Sarzosa Lorena Fernanda
Published: June 2024

El comercio electrónico ha transformado la forma en que se realizan las transacciones comerciales, planteando nuevos desafíos para la tributación. El impuesto a la renta se ve afectado por la naturaleza transfronteriza y digital de estas operaciones, lo que requiere la implementación de medidas efectivas para garantizar una tributación tanto justa como equitativa. La cooperación internacional al igual que la adopción de estándares comunes son fundamentales para abordar este desafío además de asegurar que las empresas contribuyan adecuadamente al financiamiento del Estado. Este trabajo investigativo analiza la incidencia del comercio electrónico en el Impuesto a la Renta, el motivo que incitó a indagar sobre este tema es el notable incremento de entidades que comercializan sus productos de manera electrónica, así como los inconvenientes que presenta el SRI, al recaudar los impuestos. La investigación es de tipo mixta (cualitativa – cuantitativa), como documental dado que conllevó a examinar normativas, registros, documentos vinculados con el desarrollo de este modelo de negocio, se aplicó una encuesta a la muestra de 146 compañías divididas entre Guayas (73) y Pichincha (73), los resultados evidenciaron que existen ciertos vacíos en la ley referentes a la regulación de las transacciones digitales que forman parte de esta modalidad comercial.
Development Trends of Artificial Intelligence Ethics
Authors: S* Wang , Z Xia
Published: June 2024

Artificial Intelligence Ethics is playing an important role with the development of Artificial Intelligence (AI). It is popular recognized that obeying to Artificial Intelligence Ethics guidelines and principles may resolve so many problems caused by Artificial Intelligence. This paper reviewed the development history of Artificial Intelligence Ethics, listed the main guidelines and principles of Artificial Intelligence Ethics, proposed the methods of Artificial Intelligence Ethics governance, discussed related algorithms to solve Artificial Intelligence Ethics problems.
K-Means Clustering dan Mean Variance Efficient Portfolio dalam Portofolio Saham
Authors: Pratama Yogi , Sulistianingsih Evy , Debataraja Naomi Nessyana , Imro’ah Nurfitri
Published: June 2024

K-means clustering is one of the non-hierarchical clustering algorithms that partitions n objects into k clusters. K-means clustering is used to determine which cluster an object belongs to by calculating the proximity distance between the object and the cluster center (centroid). This research aims to form a portfolio using K-means clustering and determine the weights of the portfolio using the Mean Variance Efficient Portfolio (MVEP) method. The data analyzed in this research is the closing price data of 11 stocks in the LQ45 index from January 3, 2022, to January 3, 2023. The analysis results obtained using K-means clustering reveal the formation of two portfolios. The first portfolio consists of the stocks BMRI, INCO, INDF, INTP, and SMGR. The second portfolio consists of the stocks ADRO, ANTM, BBRI, ERAA, and UNVR. Based on the MVEP method calculation, the weights of each stock in the first portfolio are 22.74\% (BMRI), 10.11\% (INCO), 49.76\% (INDF), 18.75\% (INTP), and -1.36\% (SMGR). The calculation results of stock weights show that there is a stock weight with a negative value, which is -1.36\% for SMGR, indicating a short sale in the investment. Furthermore, the weighting results for the second portfolio are 7.08\% (ADRO), 9.62\% (ANTM), 34.05\% (BBRI), 24.80\% (ERAA), and 24.45\% (UNVR).The variance values of stock portfolio 1 and stock portfolio 2 are 0.000080 and 0.000137, respectively. From the portfolio variance results, it is known that the risk of portfolio 1 is 0.008953 and the risk of portfolio 2 is 0.011706.
IN THE COURT OF ARCHES: THE PRIVATE LIFE OF JOHN LACY, RESTORATION ACTOR
Authors: Palmer Richard
Published: June 2024

The physical condition, size and complexity of the records of the Court of Arches has long posed difficulties for researchers wishing to exploit this rich resource. The task has now been made much easier by a long-term programme of conservation alongside an ongoing cataloguing project which is making detailed descriptions available for the first time. This case study uses the records of the court to provide a vivid account of the life of the Restoration actor John Lacy. The records disclose intriguing details about his private life as well as revealing just how he managed to survive the closure of the theatres during the Interregnum.
Rovibrational Transitions in HCl due to Collisions with H2: Spin-free and Hyperfine-resolved Transitions
Authors: Hoffman Daniel , Taylor Josiah , Price T. J. , Forrey Robert C. , Yang B. H. , Stancil P. C. , Zhang Z. E. , Balakrishnan N.
Published: June 2024

Hydrogen chloride (HCl) is a key repository of chlorine in the interstellar medium. Accurate determinations of its abundance are critical to assessing the chlorine elemental abundance and constraining stellar nucleosynthesis models. To aid in modeling recent and future observations of HCl rovibrational spectra, we present cross sections and rate coefficients for collisions between HCl and molecular hydrogen. Transitions between rovibrational states of HCl are considered for temperatures ranging from 10 to 3000 K. Cross sections are computed using a full dimensional quantum close-coupling (CC) method and a reduced dimensionality coupled-states (CS) approach. The CS results, benchmarked against the CC results, are used with a recoupling approach to calculate hyperfine-resolved rate coefficients for rovibrational transitions of HCl induced by H2. The rate coefficients will allow for a better determination of the HCl abundance in the interstellar medium and an improved understanding of interstellar chlorine chemistry. We demonstrate the utility of the new rate coefficients in a nonthermodynamic equilibrium radiative transfer model applied to observations of HCl rovibrational transitions in a circumstellar shell.
eDNA-based survey of the marine vertebrate biodiversity off the west coast of Guadeloupe (French West Indies)
Authors: Haderlé Rachel , Bouveret Laurent , Chazal Jordane , Girardet Justine , Iglésias Samuel , Lopez Pascal-Jean , Millon Cédric , Valentini Alice , Ung Visotheary , Jung Jean-Luc
Published: June 2024

In the marine environment, knowledge of biodiversity remains incomplete for many taxa, requiring assessments to understand and monitor biodiversity loss. Environmental DNA (eDNA) metabarcoding is a powerful tool for monitoring marine biodiversity, as it enables several taxa to be characterised simultaneously in a single sample. However, the data generated by environmental DNA metabarcoding are often not easily reusable. Implementing FAIR principles and standards for eDNA-derived data can facilitate data-sharing within the scientific community.

This study focuses on the detection of marine vertebrate biodiversity using eDNA metabarcoding on the leeward coast of Guadeloupe, a known hotspot for marine biodiversity in the French West Indies. Occurrences and DNA-derived data are shared here using DarwinCore standards combined with MIMARKS standards.
Expanding geographic distribution knowledge of Galerina marginata (Batsch) Kühner (Agaricales, Hymenogastraceae) with a novel Antarctic record
Authors: Bertazzo-Silva Fernando Augusto , Putzke Jair , Furlan-Lopes Cassiane , D'ávila Maricia , Costa Alice , Carvalho Evelise , Zorzi Ana , Schaefer Carlos
Published: June 2024

The investigation of Agaricales diversity in the Antarctica is limited, with only seven genera reported for the region. Galerina stands out as the genus with the highest species diversity, including 12 species in Antarctica. This research reports the presence of G. marginata in the region, providing the first complete morphological description for the specimen developing in Antarctica. Sampling was conducted during the Austral summer of 2022/2023 as part of the XLI Brazilian Antarctic Operation in Point Smellie, Byers Peninsula, Livingston Island, South Shetland Archipelago, Antarctica. Phylogenetic relationships reconstructed by Maximum Likelihood demonstrate that G. marginata forms a monophyletic clade with over 60% bootstrap support in most branches. The isolate in this study was found to be internal to the main cluster. Evolutionary reconstructions using the Maximum Likelihood method indicate that the branches correspond to the Antarctic isolate being an internal clade within the marginata group. Recording fungal populations in polar regions offers information about their adaptation and survival in inhospitable environments. Understanding the species' distribution in Antarctica encourages future investigations into its ecology and interactions with other organisms. Here, data are presented to establish an initial foundation for monitoring the G. marginata population in Antarctica and assessing the potential impacts of climate change on its development and survival in the forthcoming years.

We report the third occurrence of Galerina marginata (Batsch) Kühner in Antarctica and provide, for the first time, a comprehensive morphological description of an individual of the species for the Antarctic continent, accompanied by phylogenetic analyses and comprehensive discussions regarding its diversity and global distribution.
Three novel woody litter inhabiting fungi in Didymosphaeriaceae, Phaeoseptaceae and Synnemasporellaceae from Zhujiangyuan Nature Reserve, Yunnan Province, P.R. China
Authors: Zhang Gui-Qing , Wijayawardene Nalin N. , Han Li-Hong , Kumla Jaturong , Suwannarach Nakarin , Li Qiang , Elgorban Abdallah M. , Moussa Ihab M. , Coleine Claudia , Dai Dong-Qin
Published: June 2024

Zhujiangyuan Nature Reserve, located in Qujing City, Yunnan Province, China, is reported with high fauna and floral diversity, while the fungal diversity of the region is poorly documented. During the summer season in 2023, decaying wood-inhabiting microfungi were collected from different microhabitats. The novel species were identified based on morphological characteristics and phylogenetic analyses (based on combined datasets of ITS, LSU, SSU, tef1-α, and rpb2 regions). Two species belong to Dothideomycetes (viz., Spegazzinia zhujiangyuanensissp. nov. and Phaeoseptum zhujiangyuanensesp. nov. in Pleosporales) while the other one resides in Sordariomycetes (Synnemasporella faniisp. nov. in Diaporthales). The results are in conformity with the earlier studies that predicted higher fungal diversity in this region.
Repdigits base $ \eta $ as sum or product of Perrin and Padovan numbers
Authors: Taher Hunar Sherzad , Dash Saroj Kumar
Published: June 2024

Let $ \left\{E_{n}\right\}_{n\geq0} $ and $ \left\{P_{n}\right\}_{n\geq0} $ be sequences of Perrin and Padovan numbers, respectively. We have found all repdigits that can be written as the sum or product of $ E_{n} $ and $ P_{m} $ in the base $ \eta $, where $ 2\leq\eta\leq10 $ and $ m\leq n $. In addition, we have applied the theory of linear forms in logarithms of algebraic numbers and Baker-Davenport reduction method in Diophantine approximation approaches.
Newly defined fuzzy Misbalance Prodeg Index with application in multi-criteria decision-making
Authors: Liaqat Shama , Mufti Zeeshan Saleem , Shang Yilun
Published: June 2024

In crisp graph theory, there are numerous topological indices accessible, including the Misbalance Prodeg Index, which is one of the most well-known degree-based topological indexes. In crisp graphs, both vertices and edges have membership values of $ 1 $ or $ 0 $, whereas in fuzzy graphs, both vertices and edges have different memberships. This is an entire contrast to the crisp graph. In this paper, we introduce the Fuzzy Misbalance Prodeg Index of a fuzzy graph, which is a generalized form of the Misbalance Prodeg Index of a graph. We find bounds of this index and find bounds of certain classes of graphs such as path graph, cycle graph, complete graph, complete bipartite graph, and star graph. We give an algorithm to find the Fuzzy Misbalance Prodeg Index of a graph for the model of multi-criteria decision-making is established. We present applications from daily life in multi-criteria decision-making. We apply our obtained model of the Fuzzy Misbalance Prodeg Index for the multi-criteria decision-making to the choice of the best supplier and we also show the graphical analysis of our index with the other indices that show how our index is better than other existing indices.
Colères divines. Les séismes et l’histoire d’Antioche sur l’Oronte dans l’Antiquité
Authors: Saliou Catherine
Published: June 2024

Antioche sur l’Oronte a été frappée tout au long de son histoire par de nombreux séismes. Près d’une vingtaine sont attestés dans l’Antiquité. La première étape de la recherche est d’en établir la liste à partir d’une analyse critique des travaux existants. Il est difficile d’évaluer précisément leurs conséquences démographiques et matérielles réelles, même dans les quelques cas où les sources fournissent des indications chiffrées. En revanche, les textes mettent clairement en évidence l’importance de ces événements traumatiques dans la construction d’un discours historiographique sur la ville et dans la perception de son destin et de son identité, jusqu’à susciter un changement de nom, d’Antioche (la ville d’Antiochos, fondée sous la conduite de Zeus) en Théoupolis (la ville de Dieu).
Green Energy Supply to Pre-School Cluster for Sustainable Anganwadi Educational Transformation
Authors: Prasad Dharmbir , Singh Rudra Pratap , Anand Jatin , Roy Ranadip , Khan Md. Irfan
Published: June 2024

An innovative initiative for sustainable Anganwadi education transformation uses renewable energy sources like wind energy to transform early childhood education. This concept provides Anganwadi centres a reliable and environmentally friendly power supply through the use of wind turbines. The use of wind energy not only lowers carbon footprints but also gives kids a practical educational chance to understand the advantages of renewable resources. By establishing a sustainable learning environment, this innovative approach hopes to improve student attendance and academic results. For all the children and communities, the authors see a cleaner, brighter future and wind power is a key component of this shift. In the study the electricity produced is 16,959,313kW/year. The extra energy produced is sold to the grid. The return on investment is 60.2% and the simple payback year is 1.53 years. The annual energy sold to the grid is 16,956,392 kWh.
Investigating the Impact of Demographic Factors on Personal Innovativeness in Digital Wallet Usage
Authors: Sait Muhammad Azmi , Anshari Muhammad , Almunawar Mohammad Nabil , Masri Masairol
Published: June 2024

This study examines demographic factors and personal innovativeness to information technologies (PIIT) among Brunei Darussalam's digital wallet users. Analyzing data from 181 respondents, it explores the influence of gender, age, and adopter category on PIIT levels. Results show no significant correlation between gender and PIIT levels, challenging gender-based assumptions. Age groups also exhibit no significant association with PIIT levels, contrary to expectations. However, the adopter category demonstrates a significant relationship with PIIT levels, highlighting the impact of adoption behavior. Tailored marketing, product design, and policy interventions are needed for digital inclusion. Findings of this study have implications for academia, industry, and policymaking, providing insights into technology adoption behaviors in the digital wallet domain.
A Broad-specificity Neutralizing Nanobody against Hepatitis E Virus Capsid Protein
Authors: Wang Xueting , Sheng Yamin , Ji Pinpin , Deng Yingying , Sun Yani , Chen Yiyang , Nan Yuchen , Hiscox Julian A , Zhou En-Min , Liu Baoyuan , Zhao Qin
Published: June 2024

Hepatitis E virus (HEV) is a worldwide zoonotic and public health concern. The study of HEV biology is helpful for designing viral vaccines and drugs. Nanobodies have recently been considered appealing materials for viral biological research. In this study, a Bactrian camel was immunized with capsid proteins from different genotypes (1, 3, 4, and avian) of HEV. Then, a phage library (6.3 × 108 individual clones) was constructed using peripheral blood lymphocytes from the immunized camel, and 12 nanobodies against the truncated capsid protein of genotype 3 HEV (g3-p239) were screened. g3-p239-Nb55 can cross-react with different genotypes of HEV and block Kernow-C1/P6 HEV from infecting HepG2/C3A cells. To our knowledge, the epitope recognized by g3-p239-Nb55 was determined to be a novel conformational epitope located on the surface of viral particles and highly conserved among different mammalian HEV isolates. Next, to increase the affinity and half-life of the nanobody, it was displayed on the surface of ferritin, which can self-assemble into a 24-subunit nanocage, namely, fenobody-55. The affinities of fenobody-55 to g3-p239 were ∼20 times greater than those of g3-p239-Nb55. In addition, the half-life of fenobody-55 was nine times greater than that of g3-p239-Nb55. G3-p239-Nb55 and fenobody-55 can block p239 attachment and Kernow-C1/P6 infection of HepG2/C3A cells. Fenobody-55 can completely neutralize HEV infection in rabbits when it is preincubated with nonenveloped HEV particles. Our study reported a case in which a nanobody neutralized HEV infection by preincubation, identified a (to our knowledge) novel and conserved conformational epitope of HEV, and provided new material for researching HEV biology.
Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells
Authors: Verma Shivali , Bradley Marissa C , Gray Joshua , Dogra Pranay , Caron Daniel P , Maurrasse Sarah , Grunstein Eli , Waldman Erik , Jang Minyoung , Pethe Kalpana , Farber Donna L , Connors Thomas J
Published: June 2024

CD4+ regulatory T cells (Tregs) are key orchestrators of the immune system, fostering the establishment of protective immunity while preventing deleterious responses. Infancy and childhood are crucial periods of rapid immunologic development, but how Tregs mediate immune responses at these earliest timepoints of human life is poorly understood. In this study, we compare blood and tissue (tonsil) Tregs across pediatric and adult subjects to investigate age-related differences in Treg biology. We observed increased FOXP3 expression and proportions of Tregs in tonsil compared with paired blood samples in children. Within tonsil, early life Tregs accumulated in extrafollicular regions with cellular interactions biased toward CD8+ T cells. Tonsil Tregs in both children and adults expressed transcriptional profiles enriched for lineage defining signatures and canonical functionality compared with blood, suggesting tissue as the primary site of Treg activity. Early life tonsil Tregs transcriptional profiles were further defined by pathways associated with activation, proliferation, and polyfunctionality. Observed differences in pediatric tonsil Treg transcriptional signatures were associated with phenotypic differences, high proliferative capacity, and robust production of IL-10 compared with adult Tregs. These results identify tissue as a major driver of Treg identity, provide new insights into developmental differences in Treg biology across the human lifespan, and demonstrate unique functional properties of early life Tregs.
Prevalence and factors associated with adherence to Highly Active Antiretroviral Treatment at the Specialist Hospital Yola, Adamawa State, Nigeria
Authors: Stephen Roland I. , Rimande Joel , Obadiah Musa AmbiZorto , Awang Sati Klein , Dunga Jacob A , Bulundi Isaac , Atinge Sonnen
Published: June 2024

Adherence to Highly Active Antiretroviral Therapy (HAART) medication is an important predictor of a successful treatment and improvement of quality of life among People Living with Human Immunodeficiency Virus (HIV) / Acquired Immunodeficiency Syndrome (AIDS) (PLWHA). In the seven years before this study, several measures were taken to improve adherence to HAART among PLWHA at the study site, but no work has been published to establish the impact of the measures. We conducted a cross-sectional study among HIV-positive patients attending the antiretroviral clinic of State Specialist Hospital Yola, Adamawa State, Nigeria, in October-December 2019. Adherence was measured using self-report and was defined as taking at least ≥95% of the prescribed doses of Antiretroviral Therapy (ART) in the seven days preceding the survey. A total of 431 PLWHA participated in the study. There was an 88.4% adherence rate, and forgetfulness (62.2%) was the most common reason for missing HAART dosages. Adherence was found to be 92.1% (p=0.017) among those who have been on HAART for ˃2 years, 92.3% (p=0.01) among those not afraid of stigma, and 92.9% (p=0.002) among those who practice Islamic faith. Other factors associated with higher adherence included age less than 34 years, 91.2% (p=0.167), income of ˂₦30,000 per month, 88.6% (p=0.858), and less educated, 90.5% (p=0.852). The study showed adherence prevalence was 88.4%. Forgetfulness was found to be the most common reason for missing HAART dosages. We therefore recommend the introduction of medication adherence reminders into the HIV programs.
Correlation between the 4Cs and motivation to become volunteers among nursing students
Authors: Siswadi Yakobus , Saputra Bima Adi , Lebdawicaksaputri Kinanthi
Published: June 2024

During the COVID-19 pandemic, there was a surge in public enthusiasm for volunteering, including among nursing students from the Faculty of Nursing at Universitas Pelita Harapan (UPH). The UPH nursing faculty has a foundational framework known as competence, compassion, commitment, and character (4Cs), which serves as the basis for shaping each student’s personality. This study aimed to explore how the 4Cs foundational framework motivates students to become COVID-19 volunteers. Using a quantitative descriptive design with a cross-sectional approach to data collection, the study focused on UPH nursing students who volunteered for COVID-19 relief efforts, with a sample size of 100 respondents. Data analysis was conducted using Somers Δ. The findings revealed that the majority of respondents exhibited adequate motivation to volunteer, with 60% falling into this category, while 22% showed a high level of motivation. Notably, the factors of commitment (p=0.004) and character (p=0.009) demonstrated a strong correlation with encouraging nursing students to volunteer. Conversely, competence and compassion did not show a significant correlation with students’ motivation to volunteer. Among the four driving factors, only commitment and character were statistically related to students’ motivation to become volunteers.
Understanding Psychosocial Functioning, Caregiver Burden, and Neuropalliative Care in Parkinson’s Disease – A Mixed-Methods Study
Authors: Sharma Prerna , Baruah Upasana , Yadav Akanksha , Kushwaha Suman , Dhamija Rajinder K.
Published: June 2024

Background:

Despite advancements in treatment, patients with Parkinson’s disease (PD) experience a range of symptoms that affect their quality of life. There is a need to integrate neuropalliative care into standard care. The aim of the study is to understand the psychosocial functioning in persons with PD and explore their caregivers’ burden.

Methods:

The study utilizes a mixed-methods design where 50 patient–caregiver dyads attending the outpatient services of the movement disorder clinic at a tertiary care hospital were measured on psychosocial functioning and caregiver burden and palliative care outcomes for a period of 6 months. Focus group discussions were conducted with 18 patient–caregiver dyads to understand the needs of palliative care.

Results:

It was found that caregiver burden was positively correlated with palliative care outcomes scores of patients (r = 0.586) and caregivers (r = 0.675) and psychosocial functioning was positively correlated with palliative care outcomes of patients (r = 0.708). The psychosocial functioning score was higher among female patients (indicating worse functioning) than males, and female caregivers experienced significantly higher caregiver burden. The qualitative findings reveal that there is a substantial gap in awareness about palliative care, lack of information, presence of stigmatizing beliefs, and lack of adequate accessibility to palliative facilities.

Conclusion:

The study lays the foundation for future PD neuropalliative care research, guiding interventions, and exploration of regional variations in PD experiences in India. There is a need to address caregiver burden in PD in India.
Effect of topical brinzolamide on visual function and waveform in patients of infantile nystagmus syndrome: A randomized control trial
Authors: Yadav Bhupendra , Saxena Rohit , Dhiman Rebika , Kochhar Kanwal P. , Patil Ashlesh , Sharma Pradeep , Sihota Ramanjit , Tandon Radhika
Published: June 2024

Purpose:

To evaluate the effect of topical carbonic anhydrase inhibitor (brinzolamide) versus placebo on visual function and waveforms in infantile nystagmus syndrome (INS).

Design:

Prospective, placebo-controlled, double-blind, cross-over study.

Methods:

Setting- A tertiary eye care center. Patients- Cases of idiopathic INS with and without abnormal head posture aged ≥10 years who had not received previous treatment for nystagmus. Intervention- Patients were randomized into two groups. Group 1 was given placebo for 3 months, and after a washout period of 7 days started on topical brinzolamide for the next 3 months. In group 2, the order was reversed. The drops were administered topically three times (every 8 hours) in both eyes. Outcome measure- Binocular best corrected visual acuity (BCVA) using the ETDRS chart, eXpanded nystagmus acuity function (NAFX) score and INS waveforms obtained from eye movement recordings, intraocular pressure (IOP) by Goldmann applanation tonometer, near stereopsis by TNO stereo test, and change in abnormal head posture before and after intervention in the null position.

Results:

A total of 29 cases completed the study (23 with abnormal head posture; 6 without abnormal head posture)

.

A significant improvement was noted in INS waveform characteristics, mean NAFX score (P < 0.001), and mean binocular visual acuity (P < 0.001) with topical brinzolamide in comparison to baseline as well as placebo. No significant change in head position and stereopsis was noted. No side effects were reported with 3 months of brinzolamide therapy.

Conclusions:

While brinzolamide shows improvement in visual acuity and NAFX score in idiopathic INS, its clinical significance needs further evidence.
Aberration change after scleral lens wear in eyes with pellucid marginal degenerations
Authors: Dutta Ronit , Iyer Geetha , Srinivasan Bhaskar , Iqbal Asif
Published: June 2024

Purpose:

To investigate the impact of scleral lenses (SLs) on higher-order aberrations (HOAs), corrected distance visual acuity (CDVA), and contrast sensitivity (CS) in pellucid marginal degeneration (PMD) eyes.

Methods:

SLs were fitted in 24 eyes diagnosed with PMD. CDVA, CS, and HOAs were measured at baseline and with the lens on the eye. The HOAs were measured using an i-Trace aberrometer.

Results:

A statistically significant improvement was noted in CDVA (P < 0.001) with BSS lenses (0.05 ± 0.04) compared to baseline (0.42 ± 0.06). Front surface eccentricity 1 (FSE1) lens provided the best CDVA in most of the eyes. The baseline CS of 1.24 ± 0.74 improved to 1.58 ± 0.48 with SL and reported a statistically significant improvement (P < 0.001) and a gain of 6 letters. The baseline higher order-root mean square (HO-RMS) was 0.89 ± 0.53 µm, which reduced to 0.38 ± 0.24 µm (P < 0.001), and RMS coma of 0.45 ± 0.29 µm improved to 0.20 ± 0.12 µm (P < 0.001). Though there was a marginal reduction from 0.04 ± 0.14 to 0.03 ± 0.07, RMS spherical aberration did not show any statistically significant difference (P = 0.37). RMS secondary astigmatism reduced from 0.17 ± 0.15 µm to 0.08 ± 0.12 µm (P = 0.007), and RMS trefoil reduced to 0.13 ± 0.09 µm from 0.64 ± 0.36 µm (P < 0.001) with SLs and showed statistically significant improvement.

Conclusion:

SLs can be considered an effective option that corrects a significant amount of HOAs and enhances visual performances in PMD eyes.
Aggressive Angiomyxoma of Ear
Authors: Bhuskute Govind Shripad , Manogaran Ravi Sankar , Mandelia Ankur , Rao Ramnaval
Published: June 2024

Aggressive angiomyxoma (AA) is an extremely rare, locally invasive, mesenchymal tumor. It has a high propensity of recurrence and rapid growth, especially if complete excision of the lesion is not achieved at the primary surgery. Surgery with appropriate plastic reconstruction is the mainstay of treatment. We highlight two cases of AA of the temporal region, both in extremes of age group and displaying both characteristic features of this tumor recurrence and aggressive growth. Special care was taken to achieve complete excision of the tumor in the auricular–preauricular region with parotidectomy and preservation of facial nerve function. This case report highlights the aggressive pathophysiology of the tumor, with special emphasis on complete tumor removal, necessary to prevent recurrence.
Distortion-Product Otoacoustic Emission of Cochlear Hair Cells in Pediatric Patients Presenting with Various Perinatal Morbidities
Authors: Mahanta Bhaswati , Bhattacharjee Abhinandan
Published: June 2024

Background:

Hearing plays a substantial role in the growth of intellect- as well as language-related abilities in children. Congenital hearing loss leads to deficiency and defects in the growth of various abilities such as speech leading to emotional distress. The aim of our study was to detect cochlear hair cell damage in various perinatal morbidities as measured from distortion-product otoacoustic emission (DPOAE) in the pediatric age group.

Materials and Methods:

A 1-year prospective observational study was conducted on 65 children comprising 28 pediatric and 37 neonatal patients attending a tertiary care hospital.

Results:

Among 65 children, 25% of patients having perinatal risk factors failed the OAE test. The majority of neonates passed the OAE test (97.3%) as compared to the pediatric age group (60.7%). The most common risk factor associated with OAE “fail” was neonatal jaundice (100%), followed by low birth weight (35%) and respiratory distress (36%). We found no relation of “fail” OAE test with the Apgar scale (4–6). The mean signal–noise ratio (SNR) variable was highest in the frequency range of 4 and 6 kHz in neonates with statistically significant values for the frequency band of 2, 4, and 6 kHz. The above findings confirmed that the OAE recordings observed in the group of children were reliable.

Conclusion:

The SNR variable of DPOAE is an effective and reliable screening tool at particular frequencies. Emphasis on hearing screening using OAE should be prioritized in cases of neonatal jaundice and respiratory distress and also for patients in the age group from >1 month to 12 years.
Spontaneous Cerebrospinal Fluid Leak Presenting as Middle Ear Effusion Caused by Arachnoid Granulations
Authors: Yeu Wong Song , Ping Tang Ing , Ping Teoh Li , Daud Mohd Khairi Md. , Othman Nik Adilah Nik , Aziz Roziasyazni Che Abdul
Published: June 2024

While middle ear effusion (MEE) is a common ailment in children with Eustachian tube dysfunction, it occurs less frequently in adults. In such cases, a meticulous assessment is essential to discern the underlying cause of MEE. We present an unusual case of spontaneous cerebrospinal fluid (CSF) leak attributed to arachnoid granulation presenting as MEE. A 59-year-old obese female presented with right ear fullness, reduced hearing, and a persistent postnasal drip for 2 years. Audiological testing shows unilateral mild-to-moderate conductive hearing loss in the right ear. Tympanometry assessment revealed a persistent type B pattern in the right ear, indicating persistent unilateral conductive hearing loss. However, despite receiving treatment with nasal decongestants and antihistamines for 2 weeks, no signs of improvement were observed. Subsequently, a right myringotomy and grommet insertion were performed, resulting in the drainage of clear watery fluid that persisted for 2 weeks. A high-resolution computed tomographic scan of the temporal bone revealed the right MEE, bony defect in the right tegmen tympani, and bony irregularities of both tegmen tympani. Magnetic resonance imaging unveiled herniation of the right inferior temporal lobe through the identified tegmen defect. The patient subsequently underwent cortical mastoidectomy, lateral skull base repair, and mastoid obliteration. The histopathological examination of the biopsy taken from the right middle ear tissue revealed fragments of glial tissue with small fragments of trabeculae, which were confirmed by the positivity of the glial fibrillary acidic protein stain. The patient has remained asymptomatic for 10 months following the operation, and her hearing has fully returned to normal. It is advisable to consider CSF effusion as a potential differential diagnosis, particularly among adults aged over 50 years, even in the absence of a history of head trauma, mastoid surgery, or meningitis, when confronted with persistent unilateral MEE.