bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Chemical and Interpretative Methods: The Carbon-boron π-Bond as a Test Case
Authors: Gupta Radhika , Rezabal Elixabete , Hasrack Golshid , Noûs Camille , Frison Gilles
Published: April 2020

Quantum chemical calculations using DFT and NBO, ETS-NOCV, QTAIM and ELF interpretative approaches have been carried out on X-BH2+ borenium complexes for 39 divalent C-donor ligands X including various N-heterocyclic carbenes and carbones. The C-B bond length and the barrier of rotation around the C-B bond were calculated and compared with various descriptors of the C-B pi-bond strength obtained from the orbital localization, energy partitioning or topological methods. Two families of descriptors emerged: intrinsic indicators, which measure the intensity of the pi-bond in the investigated molecule, and relative indicators, among them the rotational barrier, which compare the studied molecule with its conformer in which the pi-interaction is prevented. Relative indicators are influenced by other interactions in addition to purely pi-interactions. For both families of descriptors, excellent correlations are obtained, showing that the interpretative methods, despite their conceptual differences, describe the same chemical properties. These results also reveal noticeable shortcomings in these methods, and some precautions that need to be taken to interpret their results adequately.
Mapping C−H•••M interactions in confined spaces: (α-ICyDᴹᵉ)Au, Ag, Cu complexes reveal “contra-electrostatic H-bonds” masquerading as anagostic interactions
Authors: dos Passos Gomes Gabriel , Xu Guangcan , Zhu Xiaolei , Chamoreau Lise-Marie , Zhang Yongmin , Bistri Aslanoff Olivia , Roland Sylvain , Alabugin Igor , Sollogoub Matthieu
Published: April 2020

What happens when a C−H bond is forced to interact with unpaired pairs of electrons at a positively charged metal? Such interactions can be considered as “contra-electrostatic” H-bonds, which combine the familiar orbital interaction pattern characteristic for the covalent contribution to the conventional H-bonding with an unusual contra-electrostatic component. While electrostatics is strongly stabilizing component in the conventional C−H•••X bonds where X is an electronegative main group element, it is destabilizing in the C−H•••M contacts when M is Au(I), Ag(I), or Cu(I) of NHC−M−Cl systems. Such remarkable C−H•••M interaction became experimentally accessible within (α-ICyDMe)MCl, NHC−Metal complexes embedded into cyclodextrins. Computational analysis of the model systems suggests that the overall interaction energies are relatively insensitive to moderate variations in the directionality of interaction between a C−H bond and the metal center, indicating stereoelectronic promiscuity of fully filled set of d-orbitals. A combination of experimental and computational data demonstrates that metal encapsulation inside the cyclodextrin cavity forces the C−H bond to point toward the metal, and reveals a still attractive “contra-electrostatic” H-bonding interaction.
Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a Formal Cross Rauhut-Currier Reaction
Authors: Duchemin Nicolas , Cattoen Martin , Gayraud Oscar , Anselmi Silvia , Siddiq Bilal , Buccafusca Roberto , Daumas Marc , Ferey Vincent , Smietana Michael , Arseniyadis Stellios
Published: April 2020

A highly enantioselective synthesis of α-branched acrylonitriles is reported featuring an unprecedented formal cross Rauhut-Currier reaction consisting of an asymmetric Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which involves the use of an acrylonitrile surrogate, is practical, scalable and highly versatile, and provides a straightforward access to a wide range of enantioenriched nitrile-containing building blocks without using acrylonitrile or any source of cyanide. Most importantly, it offers a new tool to incorporate an acrylonitrile moiety in an asymmetric fashion.
As-Indaceno[3,2,1,8,7,6-Ghijklm]terrylene: A Near-Infrared Absorbing C70-Fragment
Authors: Tanaka Yuki , Fukui Norihito , Shinokubo Hiroshi
Published: April 2020

Carbon and hydrogen are fundamental components of organic molecules and a fascinating plethora of functions can be generated using these two elements. Yet, realizing attractive electronic structures only by using carbon and hydrogen remains challenging. Herein, we report the synthesis and properties of the C70 fragment as- indaceno[3,2,1,8,7,6-ghijklm]terrylene, which exhibits near-infrared (NIR) absorption (up to ca. 1300 nm), even though this molecule consists of only 34 carbon and 14 hydrogen atoms. A remarkably small HOMO–LUMO gap was confirmed by electrochemical measurement and theoretical calculations. Nevertheless, as-indacenoterrylene is surprisingly stable despite the absence of peripheral substituents, which contrasts with the cases of other NIR-absorbing hydrocarbons such as biradicaloids and antiaromatic molecules. The low-energy absorption was attributed to the intramolecular charge- transfer from the electron-rich terrylene segment to the electron-deficient as- indacenopyrene segment. The results of this study thus offer fundamental insights into the design of hydrocarbons with a small band gap.
A Deep Neural Network for the Rapid Prediction of X-ray Absorption Spectra
Authors: Rankine Conor , Madkhali Marwah , Penfold Thomas
Published: April 2020

X-ray spectroscopy delivers strong impact across the physical and biological sciences by providing end-users with highly-detailed information about the electronic and geometric structure of matter. To decode this information in challenging cases, e.g. in operando catalysts, batteries, and temporally-evolving systems, advanced theoretical calculations are necessary. The complexity and resource requirements often render these out of reach for end-users, and therefore data are often not interpreted exhaustively, leaving a wealth of valuable information unexploited. In this paper, we introduce supervised machine learning of X-ray absorption spectra, by developing a deep neural network (DNN) that is able to estimate Fe K-edge X-ray absorption near-edge structure spectra in less than a second with no input beyond geometric information about the local environment of the absorption site. We predict peak positions with sub-eV accuracy and peak intensities with errors over an order of magnitude smaller than the spectral variations that the model is engineered to capture. The performance of the DNN is promising, as illustrated by its application to the structural refinement of iron(II)tris(bipyridine) and nitrosylmyoglobin, but also highlights areas for which future developments should focus.
Adrenergic Modulation with Photochromic Ligands
Authors: Prischich Davia , Gomila Alexandre M. J. , Milla-Navarro Santiago , Sangüesa Gemma , Diez-Alarcia Rebeca , Preda Beatrice , Matera Carlo , Batlle Montserrat , Ramírez Laura , Giralt Ernest , Hernando Jordi , Guasch Eduard , Meana J. Javier , de la Villa Pedro , Gorostiza Pau
Published: April 2020

Adrenoceptors are ubiquitous and regulate heart and respiratory rate, digestion, metabolism, and vascular tone. They can be activated or blocked with adrenergic drugs, but systemic administration causes broad adverse effects. We have developed photochromic ligands (adrenoswitches) to switch on and off adrenoceptor activity on demand at selected locations. Their pharmacology, photochromism, bioavailability and lack of toxicity allow photomodulating adrenergic signalling, as demonstrated by controlling locomotion in zebrafish and pupillary responses in blind mice.
Kinetic Prediction of Reverse Intersystem Crossing in Organic Donor–Acceptor Molecules
Authors: Aizawa Naoya , Harabuchi Yu , Maeda Satoshi , Pu Yong-Jin
Published: April 2020

Reverse intersystem crossing (RISC), the uphill spin-flip process from triplet to singlet excited states, plays a key role in a wide range of photochemical applications. Understanding and predicting the kinetics of such process in vastly different molecular structures would best lead to rational design of new materials. Here, we demonstrate a theoretical expression that successfully reproduces experimental RISC rate constants ranging over five orders of magnitude in twenty different molecules. We show that the spin flip occurs across the singlet–triplet crossing seam involving a higher-lying triplet excited state, where the semi-classical Marcus parabola is no longer valid. The present model explains counterintuitive substitution effects of bromine on the RISC rate constants in newly synthesized molecules, proving as predictive tool for materials design.
A futuristic study on in-vitro medical devices regulations
Authors: Naga Gouri T  , Venkatesh M P  , Balamuralidhara V  , Pramod Kumar T M
Published: April 2020

The In-Vitro Medical Devices Directive (IVDD) established in 1998 by the European Union met the requirements of the single medical device market. In the due course, IVDD could not regulate all new technical and medical developments in the sector. The IVDD 98/79/EC, was preceded with IVDR 2017//746; which defined and demonstrated conformity to essential requirements, established harmonized standards and facilitated the organization of ‘Notified Body’ (NB), Competent Authority oversight and market surveillance. IVDR implemented streamlines as defined in Annex I of the EU IVDR 2017/746 conforming to the relationships between the performance requirements and general safety, and Annex I of the EU Directive 98/79/EC for IVDD for the essential requirements. The importance of the Unique Device Identification and its implementation in the safety and conformity of the device was made stringent for the manufacturers. The recent developments in IVDR, with reference to EUDAMED database, enable the applicant for accessing of data entered for the revival, correction and the assessing of  information.
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis
Authors: Goldstein Jérémie D , Bassoy Esen Y , Caruso Assunta , Palomo Jennifer , Rodriguez Emiliana , Lemeille Sylvain , Gabay Cem
Published: April 2020

IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced psoriasis-like dermatitis. Il36rΔK mice presenting deletion of IL-36R in keratinocytes were similarly resistant to Aldara-induced ear inflammation as Il36r−/− mice, but acanthosis was only prevented in Il36r−/− mice. FACS analysis revealed that IL-36R signaling in keratinocytes is mandatory for early neutrophil infiltration in Aldara-treated ears. RNASeq and qRT-PCR experiments demonstrated the crucial role of IL-36R signaling in keratinocytes for induction of IL-23, IL-17, and IL-22 at early time points. Taken together, our results demonstrate that IL-36R signaling in keratinocytes plays a major role in the induction of Aldara-induced psoriasis-like dermatitis by triggering early production of IL-23/IL-17/IL-22 cytokines and neutrophil infiltration.
Une assassine pas comme les autres : violence sexuelle, amérindianité et écoterrorisme dans Le sang de l’or de Louise Leblanc
Authors: Hobbs Sandra
Published: April 2020

La femme qui tue dérange de façon particulière les normes sociales : les femmes nourrissent, soutiennent, compatissent… la violence leur est habituellement étrangère. Celle qui enlève la vie à un autre est donc encore plus « monstrueuse » (Gilbert) que son homologue masculin. Diverses théories orientent l’étude de la femme meurtrière – soit qu’elle cherche à devenir plus masculine, qu’elle réagit à une situation intenable ou qu’elle se démarque d’une norme qui s’applique aux femmes d’une certaine race ou classe sociale (Irwin et Pasko). Dans le cas de la représentation romanesque du meurtre féminin au Québec, on peut constater un certain écart par rapport à la réalité (Gilbert), dans le sens que la violence au féminin prend un essor dans le livre, qui est sans rapport aux statistiques de la société canadienne ou québécoise. Le roman que nous avons retenu pour cette étude – Le sang de l’or de Louise Leblanc (1989) – met en vedette une meurtrière, ce qui devrait alors choquer le lecteur. Nous verrons que dans ce roman, par contre, le portrait hautement stéréotypé du personnage principal amérindien rend la violence du personnage moins surprenante. Qu’en est-il au juste du meurtre au féminin quand la criminelle est aussi amérindienne? Nous élucidons ce sujet en tenant compte des questions de territorialité, d’histoire coloniale et d’écoterrorisme, sans perdre de vue le discours féministe qui informe le récit. De fait, tout en ayant recours à des tropes coloniaux qui remontent au dix-neuvième siècle, voire plus loin, Leblanc crée un personnage qui attire la sympathie du lecteur. En tant que jeune femme victime de violence sexuelle, Kiji est en droit de se défendre; sa défense de l’environnement justifie davantage son geste. En dépit de ces facteurs atténuants, elle demeure un personnage équivoque en raison de sa correspondance au stéréotype littéraire de l’Amérindien dans la littérature québécoise.

Mots clés : autochtone, colonie de peuplement, stéréotype, éco-terrorisme, violence sexuelle
Christophe Honoré : écrire à la première personne en tant qu’artiste homosexuel
Authors: Méghaïzerou Miriem
Published: April 2020

Christophe Honoré est l’auteur d’une œuvre à la première personne, parue entre 2017 et 2018, qui se déplie en trois volets, dont le roman Ton Père (2017), le film Plaire, aimer et courir vite (2018) et la pièce de théâtre Les Idoles (2018). Ce triptyque a principalement pour thèmes la figure de l’artiste homosexuel, la transmission et la perte. En effet, cette œuvre est hantée par la mort de personnalités chères à l’auteur, emportées par le Sida dans les années 1990. Alors, il les fait revivre et dialoguer dans la pièce de théâtre qui clôt ce triptyque, tandis que le film présente une histoire d’amour homosexuel entre un écrivain séropositif et un étudiant en cinéma et que le livre relate la paternité d’un narrateur homosexuel confronté à l’homophobie. L’article se propose d’examiner les différentes possibilités de figurations de soi en « artiste homosexuel » dans un dispositif hybride, qui convoque la littérature, le cinéma et le théâtre. Il s’agira aussi de mettre en avant l’éclatement sujet en plusieurs points, à travers les discontinuités formelles de cette œuvre. Le « je » se donne à voir dans une labilité, qui participe en retour à la construction dynamique du sujet et fait échec aux assignations à identité.

Mots-clés : autofiction, artiste homosexuel, homophobie, Sida.
L' usage de l’objet dans la pratique autobiographique de Colette Fellous
Authors: Collington Tara
Published: April 2020

La présente étude examinera la présence des objets dans deux textes de Collette Fellous,

Avenue de France (2001) et Un Amour de frère (2011), afin d’étudier leur rôle dans la pratique autobiographique de l’auteure. Fellous inclut souvent des matériaux extralittéraires dans ses textes. Le lecteur y trouve non seulement des photos de famille, mais aussi des lettres et des documents, ainsi que des images d’objets quotidiens aussi variés que des allumettes, des jouets d’enfant ou des chaussures. Il s’agit donc d’objets rendus visibles, car présents dans le texte sous forme de reproduction photographique. En même temps, son œuvre déborde d’objets invisibles qui sont décrits par le texte, mais qui n’y figurent que sous forme scripturale. Notre étude examinera donc les deux types d’objets, visibles et invisibles, afin de cerner le lien entre la mémoire et ce que Fellous appelle les « accessoires » du passé.

Mots-clés : Fellous, autobiographie, photographie, objets, mémoire
Bélizaire, Guy. Rue des rêves brisés
Authors: Sauge Laurence
Published: April 2020

compte rendu, Bélizaire, Guy. Rue des rêves brisés
Clitoria ternatea anthocyanin extract suppresses inflammation in carrageenaninduced rat paw edema via down-regulating genes of phosphoinositide 3-kinase signaling pathway
Authors: Yanti  , Sabella D. , Gunawan A.W. , Lay B.W.
Published: April 2020

Inflammation is characterized by an increase in vascular permeability leading to edema
formation. Phosphoinositide 3-kinase (PI3K) signaling pathway plays the main role to
regulate several key events in the inflammatory response to damage and infection. Our
previous in silico study showed that anthocyanin and ternatin flavonoids may offer antiinflammatory potential via molecular docking model. Here, we explored whether Clitoria
ternatea anthocyanin extract (CTA) had protective activity against inflammation via
regulating gene expression related to PI3Ks in rat edema. CTA was extracted in methanol
and acetone using maceration and lyophilization. Edema model was done by injecting
carrageenan into rat paw. Oral supplementation of CTA (100, 250, and 500 mg/kg BW)
and ibuprofen standard (15 mg/kg BW) was given to rats daily for 7 days. After sample
treatment, the right hind paw of the rat was injected with carrageenan to induce edema
condition. The ability of CTA to suppress the inflammation in paw edema was measured
by quantifying the increased percentage of rat paw volume at 1, 3, and 5 hrs after
injection. Rat paw tissue was collected, and gene expression related to PI3Ks, i.e. Akt1,
PKB, Ilk, Pdk2, Pik3Ca, and p53 was determined using quantitative PCR (qPCR).
Carrageenan showed a time-dependent increase in volume of rat paw starting from
injection until the next 5 hrs. It reached maximum volume increase of rat paw at 3 hrs
after injection. CTA treatment had a dose-dependent pattern in reducing the edema
volume in carrageenan-induced paw edema. At 500 mg/kg BW, CTA significantly
suppressed the inflammation in paw edema compared to that of positive control,
indicating by the low percentage of paw edema volume at 1, 3, and 5 hrs after carrageenan
injection. At gene level, qPCR data showed that CTA significantly down-regulated the
expression of genes involved in PI3Ks, such as Akt1, PKB, Ilk, Pdk2, Pik3Ca, and p53 in
paw tissues. Thus, CTA may have a protective effect against edema via suppressing genes
of PI3Ks.
Effect of different molecular weight on the antioxidant activity and physicochemical properties of golden apple snail (Ampullariidae) protein hydrolysates
Authors: Saallah S. , Ishak N.H. , Sarbon N.M.
Published: April 2020

Golden apple snail (GAS) is reported to have a medicine effect for treat broken bones,
back pain and stool bloody. This study was aimed to investigate the fractionation of
protein hydrolysate from the golden apple snail (GAS) using an ultrafiltration technique
with molecular weight cut-offs of 3, 5, and 10 kDa, followed by the determination of its
antioxidant activity and functional properties. In terms of antioxidant activity, fraction of 3
kDa showed the highest reducing power and DPPH radical scavenging activity.
Additionally, fraction of 5 kDa had the highest chelating effect on ferrous ion (85.6%).
The results also revealed that fraction of 3 kDa showed good emulsion activity index and
water binding capacity, while 5 kDa showed good foaming capacity and solubility. These
results suggested that GASH showed potential for application in the food industry as its
antioxidant, with strong functional properties able to be obtained by varying its molecular
weights.
Free lattices proof-theoretically
Authors: Kowalski Tomasz
Published: April 2020

A sequent system is used to give alternative proofs of two well known properties of free lattices: Whitman’s condition and semidistributivity. It demonstrates usefulness of such proof systems outside logic.
PENINGKATKAN KEMAMPUAN BERPIKIR TINGKAT TINGGI MELALUI PENGEMBANGAN BAHAN AJAR “CREATIVE FACTOR” BERBASIS PROYEK
Authors: Kusumadewi Rida Fironika , Ulia Nuhyal , Riana Ina , Tubiyanto Tubiyanto
Published: April 2020

Penelitian ini untuk mengembangkan peningkatan kemampuan berpikir tingkat tinggi menggunakan produk bahan ajar “Creative Factor” pada materi kelipatan dan faktor bilangan. Produk bahan ajar “Creative Factor” materi kelipatan dan faktor bilangan dikembangkan berdasarkan kebutuhan guru terhadap sumber referensi lain dalam pembelajaran. Penelitian ini menggunakan metode Research and Development (RnD). Pada soal pretest rata-rata siswa belum memenuhi KKM 60, dan pada soal pretest siswa mendapatkan nilai rata-rata 40. Sedangkan pada soal postest siswa sudah memenuhi KKM yaitu nilai lebih dari 60, dan mendapatkan nilai siswa rata-rata 78. Hal ini dapat disimpulkan bahwa pada bahan ajar “Creative Factor” berbasis proyek ada peningkatan pada kemampuan berpikir tingkat tinggi pada materi kelipatan dan faktor bilangan yaitu mencapai nilai 0,67 dengan interpretasi “Sedang”. Berdasarkan hasil tersebut, produk bahan ajar “Creative Factor” dapat dinyatakan meningkat pada materi kelipatan dan faktor bilangan.
ANALISIS KEBUTUHAN KAMUS SAKU (INDONESIA-INGGRIS/INGGRIS-INDONESIA) MATERI GEOMETRI
Authors: Purwaningrum Jayanti Putri , Utari Aisyah Ririn Perwikasih
Published: April 2020

Kemampuan berbahasa Inggris adalah suatu kunci keberhasilan di era global. Kemampuan tersebut diperlukan di segala bidang termasuk dalam bidang pendidikan di jenjang perguruan tinggi. Upaya yang dapat dilakukan oleh Prodi Pendidikan Matematika Universitas Muria Kudus dalam hal mengembangkan penguasan Bahasa Inggris yang berkaitan dengan pendidikan matematika adalah dengan memberikan mata mata kuliah Bahasa Inggris Pendidikan Matematika. Penelitian ini bertujuan untuk menganalisis kebutuhan sumber belajar berupa kamus saku (Indonesia-Inggris/ Inggris-Indonesia) khususnya pada materi geometri sebagai alternatif penunjang dalam mata kuliah Bahasa Inggris Matematika. Artikel ini merupakan artikel dengan jenis penelitian deskriptif dengan subjek penelitian adalah mahasiswa pendidikan matematika sebanyak delapan puluh delapan orang. Data penelitian diperoleh dari pengisian angket kebutuhan sumber belajar berupa kamus saku. Hasil analisis angket kebutuhan tersebut menunjukkan perlunya pengembangan kamus saku (Indonesia-Inggris/ Inggris-Indonesia) pada materi geometri sebagai alternatif penunjang dalam mata kuliah Bahasa Inggris Matematika. Kamus tersebut memudahkan mahasiswa dalam mengartikan kosakata matematika yang berkaitan dengan geometri dari Bahasa Indonesia ke Bahasa Inggris atau pun sebaliknya.
EXPERIMENTAL AND NUMERICAL STUDIES ON MULTI-BOLT DOUBLE COVER BUTT JOINTED GLASS FIBRE REINFORCED COMPOSITE LAMINATES WITH ALUMINIUM BUTT STRAPS
Authors: Sastry S. S. Subramanya , Reddy Sivanagaraju , Babu K. Naresh
Published: April 2020

Numerical and experimental studies on multi-bolt double cover butt jointed glass fibre reinforced composite laminates with Aluminium butt straps (size 270 x 72 x 3/4/5 mm) subjected to a tensile load are presented. Experiments were conducted using the assembled specimens in Instron testing machine under uniaxial load. The test specimens exhibited bearing failure of the laminate at all bolt points followed by net tension failure along the line of bolts close to the grips. Investigation are conducted to study the effects of material composition, consistency of fabrication, bearing-bypass interaction / damage onset, specimen thickness on the stress-strain behaviour of the specimen, load distribution in bolts, types of fit and friction, material anisotropy and contact condition under bolt preload. Influence of these parameters on the contact stresses around the bolt and stresses in the butt straps are discussed. Finite element analysis was carried out using ANSYS for various parameters and results were compared with test data.
STRUCTURAL ANALYSIS OF SEMANTIC RELATIONS REGARDING INTEGRATION AND ASSOCIATION OF SEMANTIC NETWORK IN VOCBENCH AS AN AGRICULTURAL ONTOLOGY
Authors: Amirhosseini Maziar , Salim Juhana
Published: April 2020

The purpose of this article is to analyze semantic relations based on graph-independent structural analysis in VocBench. The mix-method of deductive and inductive approach is adapted in operating the research methodology, especially for data collection. The research data are structural domains of semantic relations in ontologies. The data resource is the authoritative agricultural ontology, VocBench, that has been originated by Food and Agricultural organization (FAO), United Nation. VocBench includes around 40000 concepts. The sample size is around 1500 concepts. Sampling technique used is the stratified random sampling. The data analysis results are employed in the SPSS and Excel software using descriptive and proportional analysis. The research results reveal that the taxonomic relations cover a wide area in VocBench. Moreover, the overloading was not seen in the usage of non-taxonomic relations. The high frequency in the usage of the semantic relations’ output might be implied the possibility of the width (i.e., exhaustivity) in semantic network in VocBench.
Modeling the contribution and benefits of company stakeholders
Authors: Tkachenko Irina , Pervukhina Irina , Zlygostev Aleksandr
Published: April 2020

The article reviews the theory and methodology and searches for relevant tools for modeling stakeholder contribution and benefits. The methodological framework comprises the stakeholder approach, the concept of sustainable growth and shared values. The study presents two econometric models of stakeholder value contribution and a mathematical model of stakeholder benefits. The models are built on panel data of several Russian banks. The authors look upon banks as constituents of the financial infrastructure essential for the existence of integrated business structures. Our findings show that the most appropriate proxy indicator for modeling monetary stakeholder value is sales revenue. We conclude that, for practical use, it is necessary to explore the relationships between different models and possible ways of their integration and develop a methodology for their evaluation and comparison. Further research should be related to the choice of factors affecting the model, the validity of the choice, the analysis of the regression model in order to infer the stakeholder contribution. To achieve technological breakthroughs, it is important to study value assessment procedures for stakeholders in the conditions of innovative and technological transformation of new forms of business organization, including network-based models, smart industries and ecosystems.
Clima organizacional y percepción de la calidad en una institución de salud de la ciudad de Manizales 2018 – 2019.
Authors: Agudelo Loaiza Rubén Darío , Peña López Paula Andrea , Hoyos Loaiza Carolina , Jiménez Montoya Mario Alberto
Published: April 2020

Objetivo: determinar la relación entre el clima organizacional y la percepción de la calidad de los servicios de salud en una institución de salud de la ciudad de Manizales periodo 2018 – 2019. Materiales y métodos: es un estudio de tipo cuantitativo, analítico – transversal que mide la relación entre el clima organizacional y la percepción de calidad mediante dos instrumentos: uno es la evaluación de 4 áreas críticas para describir la primera, y otro, el estudio de la calidad del servicio percibida por los clientes, en donde se consideraron 5 variables. La población estudiada referente al clima organizacional comprendió 183 personas del área asistencial y 99 del área administrativa de la clínica, y la población referida a la percepción de la calidad incluyó 382 clientes. Resultados: los resultados exponen un clima organizacional satisfactorio para el personal administrativo, frente a una percepción medianamente satisfactoria para el personal asistencial. La percepción externa de la calidad arroja una puntuación promedio entre expectativas y percepción de 6,7%, encontrándose dentro de los criterios de satisfacción. Conclusión: Se concluye que, aunque se cuente con resultados satisfactorios en el clima organizacional, la calidad de la atención en salud precisa mejorar en todas sus dimensiones. Se requiere tomar medidas para que los usuarios perciban mejor la calidad en la atención de la clínica. No necesariamente el tener un clima organizacional satisfactorio garantiza que los usuarios lo perciban igual en la atención en salud en la entidad estudiada.
IDENTIFIKASI KESALAHAN MATEMATIKA SISWA SMP BERDASARKAN TAHAPAN KASTOLAN
Authors: Raharti Antonia Dwi , Yunianta Tri Nova Hasti
Published: April 2020

The study aims to identify kinds of high school students’ misrepresent in doing their tasks and to provide the appropriate scaffolding as a solution to help the students. This is a qualitative descriptive research. The research subject consists of three junior high school students who have different abilities in Mathematics. They were selected out of 92 students. This research studied the conceptual errors, procedural mistakes, and students’ technical mistakes in working on the problems based on the stages of Kastolan mistakes and the scaffoldings given. Furthermore, the data were collected by using the way of testing, interviewing and documenting techniques. The research data were guarantee validated with the triangulation method. The result of the research showed that there were some errors done by the students in doing the tasks. They were the conceptual errors, procedural mistakes, and technical errors. The scaffoldings given to help the students do the tasks for Level 1 (environmental provisions), Level 2 (explaining, reviewing dan restructuring), and Level 3 (developing conceptual thinking).
Crop wild relatives in the Magadan province of Russia: perspectives of gene pool conservation
Authors: Talovina G. V.
Published: April 2020

Eight species classified as rare in the Magadan Province, including those located at the boundary of their natural distribution area, with a narrow ecological amplitude, require not only monitoring of the known, but also search for new populations. These species can be recommended for the inclusion in the Red List of Crop Wild Relatives of the Far East. Most successfully these species can be conserved in protected areas with a special conservation regime. Populations of three species recorded in the Magadansky State Nature Reserve (Allium ochotense Prokh., Caragana jubata (Pall.) Poir. and Oxycoccus palustris Pers.) should be monitored on a regular basis. The occurrence of Rheum compactum L. in the nature reserve needs to be confirmed. Also, Rheum compactum L. and others species not recorded in the nature reserve, i.e., Artemisia dracunculus L., Bromopsis canadensis (Michx.) Holub, Dracocephalum stellerianum F. Hiltebr. and Linum komarovii Juz., require a search for stable cenoses (and establishment of intracenotic relations) in order to justify the need in creating special nature micro-reserves, including those in other specially protected areas of the province.
Educación quirúrgica en Colombia en la era del COVID–19
Authors: Sánchez Ussa Sebastián , Ariza Gutiérrez Aníbal
Published: April 2020

La enfermedad por Coronavirus-2 en poco tiempo ha logrado encender las alarmas de los sistemas de salud a nivel mundial. Además de las implicaciones económicas, sanitarias, políticas, culturales y sociales, está claro que ha cambiado la vida de los seres humanos incluyendo como se desarrollan los programas de postgrado en medicina.

Múltiples comunidades científicas alrededor del mundo han manifestado la necesidad de diferir los procedimientos quirúrgicos electivos y priorizar la atención de los pacientes por encima de la academia, lo que podría disminuir la exposición de residentes de cirugía general a actos quirúrgicos esenciales para su aprendizaje.

Como respuesta a ello, los autores presentan este artículo en donde se discute el papel de la educación virtual y la simulación como posibles respuestas a la dificultad educativa que representa la pandemia del COVID-19.
Efecto del envejecimiento sobre la capacidad reproductiva de Quercus suber en bosques maduros de espacios protegidos
Authors: Pardos Mínguez Marta , Madrigal Guillermo , Robledo Juan J , Climent José , Alía Ricardo , Montes Fernando , Camarero J. Julio , Rubio-Cuadrado Álvaro , Calama Rafael
Published: April 2020

La disponibilidad de semilla y su viabilidad son procesos clave para la persistencia de los bosques maduros. Existen evidencias de que la senescencia en los árboles no disminuye la fecundidad en edades avanzadas, pero se desconoce si  tiene efectos sobre la viabilidad de la progenie. Este trabajo analiza la influencia de la edad del árbol sobre los atributos biométricos de la semilla, la germinación y la emergencia en los bosques maduros de Quercus suber en los Parques Nacionales de Cabañeros y Monfragüe. En cada uno de los PPNN se seleccionaron 45-48 individuos de Quercus suber, entre jóvenes y senescentes, cubriéndose el rango de diámetros encontrados (24 a 100 cm en el PN de Cabañeros y 24 a 176 cm en el PN de Monfragüe). Se tomaron sus coordenadas y se midió su tamaño (diámetro, altura y diámetros de copa). Además, se estimó la edad a 1,30 m de altura (dbh) mediante la extracción de testigos de madera. En diciembre de 2018 se recogió toda la semilla presente en los individuos seleccionados, que no fue muy abundante debido a la marcada vecería en 2018. Se determinaron los caracteres biométricos de cada bellota (peso fresco, diámetro y longitud), analizándose el efecto de la edad del árbol, a través del dbh. Los resultados muestran el efecto del sitio, la edad del árbol y el tamaño de la bellota, tanto en la producción de semilla, como en su caracterización biométrica, germinación y emergencia, aunque la baja cosecha registrada en 2018 enmascara las diferencias esperadas.
THE RELATIONSHIP BETWEEN MACROECONOMIC FACTORS AND CHILD HEALTH: AN ECONOMETRIC ANALYSIS
Authors: ÇIRAKLI Ümit
Published: April 2020

The aim of this study is to reveal the relationship between macroeconomic factors and child health and also whether the changes in macroeconomic factors affect child health in Turkey. In this study, real GDP, unemployment, inflation, under-one-mortality and under-five mortality rates between 1974 and 2015 in Turkey were examined using the ARDL (Autoregressive Distributed Lag) bounds testing approach. As a result of the study, it is concluded that economic growth in terms of real GDP has an adverse effect on child health. Also, it is concluded that economic crises have positive effects on children's health as well as negative effects. This study investigated the relationship between macro economy and child health. The results of the study provide evidence that economic growth may adversely affect child health. This study also provides some clues for policymakers to protect child health from negative effects of economic crises. It is suggested that maternity leaves and financial benefits should be increased to protect child health from the negative effects of economic fluctuation. It is also important to increase the food support to poor families in times of economic crisis.
COVID-19 Safety Tips - Consejos de seguridad COVID-19- (English + Spanish)
Authors: Mukherjee Arka Prava
Published: April 2020

Este documento se preparó sobre la base de las experiencias personales del autor durante el brote DE COVID-19 en China. El autor adoptó estas medidas para mantenerse a salvo durante el proceso de cuarentena de 40 días que tuvo que soportar desde el 25 de enero de 2020 hasta el 10 de marzo de 2020. El autor es un científico y es un ciudadano indio que actualmente trabaja para una empresa multinacional. El autor solicita sinceramente a todos los lectores que utilicen este documento con sentido común y se adapten de acuerdo a sus condiciones locales, fuente de alimentos y situación financiera. Los consejos proporcionados son para aliviar a las personas que sufren de bloqueo COVID-19 y se ha hecho de buena fe. Por favor, use el sentido común y no ignore la ciencia. Este documento fue originalmente diseñado para su distribución dentro del círculo de amigos del autor. Este documento se utilizará más adelante para escribir un informe de proyecto.
MOUSE PADA KOMPUTER (HADRWARE)
Authors: Sihombing Wirdayanti
Published: April 2020

Penggunaan mouse secara umum masih membutuhkan mouse pad atau permukaan yang datar agar mouse tersebut dapat digerakkan dengan baik sehingga kursor pada layar dapat bergerak sesuai dengan arah gerakan yang diinginkan. Meskipun desain mouse cukup berkembang hingga saat ini, tetapi kebutuhan akan alat yang praktis dan dapat digunakan dalam kondisi apapun belum dapat terpenuhi. Untuk itu, dibutuhkan pengembangan mouse agar dapat dioperasikan secara praktis di berbagai kondisi. Purwarupa mouse keypad ini berfungsi sebagai alat untuk menggerakkan kursor pada layar komputer dan memasukkan huruf dan simbol seperti pada mouse dan keyboard pada umumnya. Komponen yang digunakan di dalam sistem ini yaitu mikrokontroler ATMega32 dan ATMega8, sensor akselerometer H48C, keypad matriks 4x4, IC A2601, dan XBee. Sensor akselerometer H48C digunakan untuk membaca percepatan pergerakan tangan, keypad digunakan sebagai tombol masukan huruf seperti pada keyboard, IC A2601 digunakan sebagai mouse kontroler, XBee untuk komunikasi nirkabel, sedangkan mikrokontroler ATMega32 dan ATMega8 digunakan sebagai pusat pengontrol. Purwarupa mouse keypad akselerometer ini dapat digunakan sebagai pengganti mouse dan keyboard dengan sampling rate mouse sebesar 72 Hz dan resolusi mouse 937 DPI. Tetapi masih diperlukan pengembangan lebih lanjut agar bentuk dan antarmuka yang digunakan lebih baik.
Prosodic processing in sentences with ‘only’ in L1 and L2 English
Authors: Ganga Rachida , Ge Haoyan , Struiksma Marijn , Yip Virginia , Chen Aoju
Published: April 2020

This paper reports on an EEG study on the processing of prosodic cues to contrast in sentences with 'only' in Dutch learners of English and native speakers of English.
Clueing in Mythical History
Authors: Mitravinda Kakarla Sai , R Pavithra
Published: April 2020

“Fact is everybody’s truth; Fiction is nobody’s truth; Myth is somebody’s truth.” The present paper is about myths and its subsistence till now. Myths have fed the imaginations and souls of humans for thousands of years. It has shown us fascinating heritage of gods, heroes, epic adventures, spooky stories and things that would make an individual question about science. In this article, few concepts have been explored such as, ‘myths- its origin ,the actual account in history, its major role in today’s society, speculation of urban myths and its popularity, famous mythologies, and all its impact on the present society.
Perangkat keras komputer
Authors: hasri yaumil
Published: April 2020

Pengertian dari hardware atau dalam bahasa Indonesia-nya disebut juga dengan nama “perangkat keras” adalah salah satu komponen dari sebuah komputer yang sifat alatnya bisa dilihat dan diraba secara langsung atau yang berbentuk nyata, yang berfungsi untuk mendukung proses komputerisasi. Hardware dapat bekerja berdasarkan perintah yang telah ditentukan ada padanya, atau yang juga disebut dengan istilah instruction set. Dengan adanya perintah yang dapat dimengerti oleh hardware tersebut, maka hardware tersebut dapat melakukan berbagai kegiatan yang telah ditentukan oleh pemberi perintah.
Mechanistic Inferences from Clinical Reports of SARS-CoV-2
Authors: Jenkins Meagan M , McCaw Tyler R , Goepfert Paul A
Published: April 2020

SARS-CoV-2 was identified as the causative pathogen in an outbreak of viral pneumonia cases originating in Wuhan, China, with an ensuing rapid global spread that led it to be declared a pandemic by the WHO on March 11, 2020. Given the threat to public health posed by sequelae of SARS-CoV-2 infection, the literature surrounding patient presentation in severe and non-severe cases, transmission rates and routes, management strategies, and initial clinical trial results have become available at an unprecedented pace. In this review we collate current clinical and immunologic reports, comparing these to reports of previous coronaviruses to identify mechanisms driving progression to severe disease in some patients. In brief, we propose a model wherein dysregulated type I interferon signaling leads to aberrant recruitment and accumulation of innate immune lineages in the lung, impairing establishment of productive adaptive responses, and permitting a pathologic pro-inflammatory state. Finally, we extend these findings to suggest possible treatment options that may merit investigation in randomized clinical trials.
Improving Student Communication Skills In Learning Indonesian Language Through Collaborative Learning
Authors: Kusmiarti Reni , Yuniati Ira , Noermanzah
Published: April 2020

Some research results state that students' communication skills have not shown adequate abilities. In terms of communication skills can affect the development of intellectual abilities, emotional and social maturity, and solving various problems faced by them at school. This research is intended to provide an understanding of improving students' communication skills in learning Indonesian through Collaborative Learningat SMK Negeri 1 BengkuluCity. This type of research is a classroom action research with Hopkins model. Data collection techniques carried out in the form of observation, tests, and documentation. Data analysis techniques through the analysis of observational data, calculating the average value of communication skills, analyzing documentation data, and conclusions. The data validity test uses a data source triangulation test. Based on the results of the study note that there is an increase in communication skills, both verbal skills, vocal skills, and body skills of high school students.
"Pemanfaatan Bulu Babi (Diadema Setosum) Sebagai Kebutuhan Farmatologi dan Sumber Pangan"
Authors: Kakilo Mohamad Rizki
Published: April 2020

Indonesia adalah Negara maritim terbesar di dunia dengan luasan wilayah daerah Indonesia yang dua pertiganya itu adalah lautan, yang terbagi atas laut pesisir, selat, teluk, dan laut lepas (Subekti, 2010). Serta merupakan Negara kepulauan terbesar didunia juga (Malta dkk, 2018), dengan memiliki kurang lebih 81.000 km panjang garis pantainya (Baransano dan Mangimbulude, 2011). Kekayaan sumberdaya alamnya khusunya kelautan dan perikanan dengan begitu banyaknya dan melimpah (Zaki dan Hidayat, 2017), pemanfaatan bulu babi sebagai makanan sudah lama dilakukan dan umumnnya dan umumnya ada yang mengonsumsinya saat masih segar dan ada juga yang sudah dimasak dengan cara digoreng, dikukus ataupun dibakar. Pemanfatan bulu babi (Diadema setosum) untuk dijadikan bahan konsumsi memang sangat bagus dikarenakan pada bulu babi mengandung vitamin A, Vitamin B kompleks, lima asam amino esensial bagi orang dewasa, dua asam amino esensial untuk anak-anak dan juga mineral berguna untuk meningkatkan otak serta menambah jumlah pada sel otak balita (Pringgenies, 2011 unpublish dalam Pringgenies dkk, 2013). Serta hewan bulu babi dapat juga digunakan sebagai obat luka bakar (Karmila dan Badila, 2019), bulu babi juga memiliki potensi dalam antibiotik terbaru diperairan karena adanya senyawa bioaktif yang terdadap didalam tubuh bulu babi (Abubakar et al, 2012 dalam Indrawati dkk, 2018).
Reliability (or Lack Thereof) of Smartphone-Delivered Visual Dot Probe Attention Bias Indices
Authors: Zainal Nur Hani Hani , Jacobson Nicholas C.
Published: April 2020

Cognitive bias theories posit that generalized anxiety disorder (GAD) and social anxiety disorder (SAD) are entwined with attention bias (AB) toward threats, commonly indexed by faster response time (RT) on threat- congruent (vs. incongruent) trials on the visual dot probe (VDP). Moreover, although smartphone VDP assessments have been developed, their psychometric properties are understudied. This study thus aimed to assess the retest-reliability and internal reliability of 6 smartphone-delivered VDP AB and related indices in persons with and without GAD and SAD (Global ABI, Disengagement Effect, Facilitation Bias, AB Variability [ABV], Congruent RT, Incongruent RT). Participants (n = 819) completed a five-trial smartphone-delivered VDP for at least one session. Of these, 294, 151, 94 participants completed 2, 5, and 12 sessions, respectively, across 2 weeks. Across 5 trials per session, Global ABI, Disengagement Effect, and Facilitation Bias had low reliability estimates (mean intra-class correlation coefficient [ICC] = 0.01–0.51; split-half reliability [r] = 0.01–0.18). Conversely, retest-reliability and internal reliability were good for Congruent RT and Incongruent RT (mean ICCs = 0.72–0.97; r = 0.37–0.92). Across 2, 5, and 12 sessions, poor retest-reliability and internal reliability estimates were consistently observed for all 6 AB and related indices. Compared to non-anxious controls, Global ABI and Facilitation Effect were stronger for those with GAD (d = 0.16–0.21) and SAD (d = 0.20–0.25), with negligible-to-small effect sizes. Theoretical and clinical implications, alongside suggestions to improve the reliability of smartphone VDP apps, are discussed.
PERANGKAT KERAS KOMPUTER
Authors: pramudita natri
Published: April 2020

Perangkat keras komputer adalah semua bagian fisik komputer, dan dibedakan dengan data yang berada di dalamnya atau yang beroperasi di dalamnya, dan dibedakan dengan perangkat lunak (software) yang menyediakan instruksi untuk perangkat keras dalam menyelesaikan tugasnya.Salah satu teknologi yang paling maju perkembangannya adalah komputer. Pada awalnya fungsi komputer sangat berbeda dengan fungsi komputer saat ini. Dahulu komputer digunakan sebagai alat hitung. Sesuai dengan bahasa latinnya yaitu computare yang artinya menghitung. Namun komputer mengalami perkembangan yang sangat pesat, di zaman sekarang komputer tidak lagi digunakan sebagai alat hitung tetapi komputer telah dapat digunakan sebagai alat elektronik untuk mengolah kata dan data. Namun fungsi komputer bukan hanya itu, komputer telah menjadi teknologi yang canggih dan bisa dikatakan sebagai alat yang serba bisa. Teknologi komputer yang kita kenal tidak terlepas dari dua komponen yaitu : hardware (perangkat keras) dan software (perangkat lunak) yang saling berkaitan dan mendukung satu sama lain. “Komputer memproses data dengan menggunakan kendali dari sekumpulan instruksi yang disebut dengan program komputer.Program computer ini memandu kerja dari komputer yang secara berstruktur yang disusun oleh orang yang disebut programmer.Berbagai peralatan terdapat di dalam suatu system komputer yang disebut dengan perangkat keras( hardware atau sering disingkat h/w), di antaranya adalah keyboard, monitor, disk, memory, dan CPU. Sedangkan program untuk menjalankan suatu computer disebut perangkat lunak (software atau disingkat s/w).dengan demikian system computer terdiri dari perangkat keras dan perangkat lunak serta manusia yang mengoperasikan maupun yang memprogramnya (brainware atau sering disingkat b/w)”(Julio, 2011).
perangkat keras
Authors: larasati aulya triya
Published: April 2020

Semakin majunya perkembangan jaman dan persaingan globalisasi yang terjadi mengharuskan setiap individu memiliki kreativitas dan semangat yang tinggi untuk menjalankan roda kehidupannya yakni dengan penggunaan teknologi informasi seperti multipedia.Salah satu teknologi yang paling maju perkembangannya adalah komputer. Pada awalnya fungsi komputer sangat berbeda dengan fungsi komputer saat ini. Pada awalnya fungsi komputer sangat berbeda dengan fungsi komputer saat ini. Komputer diawali sebagai mesin yang ukurannya sama besar dengan sebuah ruangan yang melakukan tugas-tugas sederhana seperti aritmatika