bluuebunny/crossref_metadata_2025 huggingface dataset:
Single HER2-positive tumor cells are detected in initially HER2-negative breast carcinomas using the DEPArray™–HER2-FISH workflow
Authors: Grüntkemeier Lisa , Khurana Aditi , Bischoff Farideh Zamaniyan , Hoffmann Oliver , Kimmig Rainer , Moore Mathew , Cotter Philip , Kasimir-Bauer Sabine
Published: January 2022

Background

In breast cancer (BC), overexpression of HER2 on the primary tumor (PT) is determined by immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to stratify samples as negative, equivocal and positive to identify patients (pts) for anti-HER2 therapy. CAP/ASCO guidelines recommend FISH for analyzing HER2/neu (ERBB2) gene amplification and for resolving equivocal HER2 IHC results. However, pre-analytical and analytical aspects are often confounded by sample related limitations and tumor heterogeneity and HER2 expression may differ between the PT and circulating tumor cells (CTCs), the precursors of metastasis. We used a validation cohort of BC patients to establish a new DEPArray™-PT-HER2-FISH workflow for further application in a development cohort, characterized as PT-HER2-negative but CTC-HER2/neu-positive, to identify patients with PT-HER2 amplified cells not detected by routine pathology.

Methods

50 µm FFPE tumor curls from the validation cohort (n = 49) and the development cohort (n = 25) underwent cutting, deparaffinization and antigen retrieval followed by dissociation into a single-cell suspension. After staining for cytokeratin, vimentin, DAPI and separation via DEPArray™, single cells were processed for HER2-FISH analysis to assess the number of chromosome 17 and HER2 loci signals for comparison, either with available IHC or conventional tissue section FISH. CTC-HER2/neu status was determined using the AdnaTest BreastCancer (QIAGEN, Hilden, Germany).

Results

Applying CAP/ASCO guidelines for HER2 evaluation of single PT cells, the comparison of routine pathology and DEPArray™-HER2-FISH analysis resulted in a concordance rate of 81.6% (40/49 pts) in the validation cohort and 84% (21/25 pts) in the development cohort, respectively. In the latter one, 4/25 patients had single HER2-positive tumor cells with 2/25 BC patients proven to be HER2-positive, despite being HER2-negative in routine pathology. The two other patients showed an equivocal HER2 status in the DEPArray™-HER2-FISH workflow but a negative result in routine pathology. Whereas all four patients with discordant HER2 results had already died, 17/21 patients with concordant HER2 results are still alive.

Conclusions

The DEPArray™ system allows pure tumor cell recovery for subsequent HER2/neu FISH analysis and is highly concordant with conventional pathology. For PT-HER2-negative patients, harboring HER2/neu-positive CTCs, this approach might allow caregivers to more effectively offer anti-HER2 treatment.
Reducing impacts of rice fields nitrate contamination on the river ecosystem by a coupled SWAT reservoir operation optimization model
Authors: Sedighkia Mahdi , Datta Bithin , Abdoli Asghar
Published: January 2022

The present study proposes a multipurpose reservoir operation optimization for mitigating impact of rice fields’ contamination on the downstream river ecosystem. The developed model was applied in the Tajan River basin in Mazandaran Province, Iran, in which the rice is the main crop. We used soil and water assessment tool (SWAT) to simulate inflow of the reservoir and nitrate load at downstream river reach. Nash–Sutcliffe model efficiency coefficient was used to measure the robustness of SWAT. NSE indicated that SWAT is acceptable to simulate nitrate load of the rice fields. The results of SWAT was applied in the structure of a multipurpose reservoir operation optimization in which three metaheuristic algorithms including differential evolution algorithm, particle swarm optimization and biogeography-based algorithm were utilized in the optimization process. Reliability index, mean absolute error and failure index were used to measure the robustness of the optimization algorithms. Fuzzy Technique for Order of Preference by Similarity to Ideal Solution was utilized to select the best algorithm. Based on results, particle swarm optimization is the best method to optimize reservoir operation in the case study. The reliability index and mean absolute error for water supply are 0.6 and 5 million cubic meters, respectively. Furthermore, the failure index of contamination is 0.027. Hence, it could be concluded that the proposed optimization system is reliable and robust to mitigate losses and nitrate contamination simultaneously. However, its performance is not perfect for minimizing impact of contamination in all the simulated months.
Fin actuation, thrust vector control and landing leg mechanisms design for the RETALT VTVL launcher
Authors: Krammer Anett , Blecha Luc , Lichtenberger Marc
Published: January 2022

To foster the competitiveness of the European industry in the global launcher market, the need arose to build up the necessary know-how on state-of-the-art vertical take-off vertical landing (VTVL) concepts and corresponding technologies. In the EU Horizon 2020 project RETALT (RETro propulsion Assisted Landing Technologies), the VTVL approach applying retro propulsion is investigated for two-stage-to-orbit (TSTO) and single-stage-to-orbit (SSTO) reusable launch vehicles, these configurations are named RETALT1 and RETALT2. In the project framework investigation of both reference configurations is performed in several areas: aerodynamics, aerothermodynamics, flight dynamics and guidance, navigation, and control (GNC), as well as thermal protection and structures and mechanisms. Focusing on solutions for the RETALT 1 launch vehicle, Almatech contributes with the design of mechanisms to actuate the aerodynamic controls surfaces, retain and deploy the landing legs and provide means to dissipate energy during touch-down. Demonstrators of these mechanism are also built during the project. In addition to the above activities, Almatech proposes thrust vectoring solutions. This paper presents an overview of these activities and results obtained so far.
Fooled by facts: quantifying anchoring bias through a large-scale experiment
Authors: Yasseri Taha , Reher Jannie
Published: January 2022

Through a large-scale online field experiment, we provide new empirical evidence for the presence of the anchoring bias in people’s judgement due to irrational reliance on a piece of information that they are initially given. The comparison of the anchoring stimuli and respective responses across different tasks reveals a positive, yet complex relationship between the anchors and the bias in participants’ predictions of the outcomes of events in the future. Participants in the treatment group were equally susceptible to the anchors regardless of their level of engagement, previous performance, or gender. Given the strong and ubiquitous influence of anchors quantified here, we should take great care to closely monitor and regulate the distribution of information online to facilitate less biased decision making.
Laparoscopic splenectomy: how minimal can we make it?
Authors: Fadipe Adetokunbo , Wilkinson David , Peters Robert , Doherty Catherine , Lansdale Nick
Published: January 2022

Aims

Laparoscopic splenectomy (LS) is routinely performed in children, however, a large spleen in a small child can pose significant operative challenges. We instigated a highly standardised surgical and anaesthetic approach to LS to minimise surgical trauma and enhance recovery. The aim of this study was to assess the outcomes of this programme.

Methods

Prospective study of all LS’s performed 2018–2021. Surgical approach was via one 10 mm and three 5 mm ports. Early hilar control was accomplished with Hem-o-loks. Splenic retrieval via the 10 mm incision used finger morcellation within an Espiner EcoSac. Anaesthesia utilised a standardised regime of agents and bupivacaine was infiltrated to the splenic bed and wound sites. Post-operative opiates were minimised. Data are presented as median [IQR].

Results

Twenty consecutive children were included. Indications for LS were hereditary spherocytosis (n = 12), sickle cell disease (n = 6), beta-thalassaemia (n = 1) and splenic haemangiomatosis (n = 1). Age at surgery was 101 months [75–117] and weight 30 kg [21–37]. Splenic size was 13.4 cm [12–14.4]. Operative time was 178 min [156–185]. There were no open conversions and no significant intra or post-operative bleeding. One patient developed pancreatitis. Median post-operative pain score was 1 [1–3]. Median length of stay was 2 days [2–3].

Conclusion

LS is feasible, safe and efficient in smaller children with large spleens. This standardised programme of anaesthesia and surgery based around a core team reliably results in few complications, good analgesia and short length of stay.
Influence of regeneration process parameters on geometry and defects of clearance surface of planer knives used in wood planing process
Authors: Sutowski Paweł , Nadolny Krzysztof , Sutowska Marzena , Myśliński Piotr , Gilewicz Adam , Warcholiński Bogdan
Published: January 2022

A properly implemented strategy regarding the planer knife regeneration process, may not only restore the original cutting ability of the tool, but even increase its operational quality, including its durability for industrial woodworking processes. This article presents experimental results and discussion in respect of sharpening planer knives with cubic boron nitride grinding wheels. Both the grinding conditions and machining surface quality were analyzed. Application of improper size or loads of abrasive grains may lead to the appearance of grinding burns on a machined surface, or result in a surface with cracks and grooves. The results of the measurements carried out indicate that surfaces with reduced values of roughness and waviness parameters can be obtained, even up to 22% (as in the case of the reduced peak height parameter, Spk) in relation to new knives, prepared at a factory. The value of St and Sds parameters are almost the same as reference knife (deviation up to 3%). Due to machining marks, the total waviness exceeds 33%. Our research also shows that due to the technological quality of the knife surfaces, it is beneficial to use CBN grains with a low depth of cut (a
e no more than 0.02 mm), but a moderate or high feed rate (the best choice is about 470 mm/min for v
ft). Presented results constitute an important know-how for the grinding process with the use of grinders used by operators (like WEINIG Rondamat 980) during the sharpening of planer cutter heads in the wood industry.
Exploring discourse-based organizational change in Japan: practicing between dominant and alternative discourses
Authors: Nagaishi Makoto
Published: January 2022

The primary objective of this study is to respond to Grant and Marshak’s (J Appl Behav Sci 47:204–235, 2011) call for a move toward change perspectives that emphasize the generative nature of discourses, narratives, and conversations and how change practitioners discursively facilitate emergent processes. This article attempts to explore the question, “Can we specify the conditions and sources which make generative conversations emerge and may lead to a successful change effort in Japan?” The abductive inquiry into the question indicates that the generative change process convinces change sponsors that changing the dominant discourses and welcoming alternative ones can lead to the long-term development of the organization and the members. With respect to the sources of alternative discourses, psychological safety and trust in the external authority figure are generally required. The importance of survival anxiety and talent diversity may vary across the broad contexts on which organizations depend.
AI ethics and systemic risks in finance
Authors: Svetlova Ekaterina
Published: January 2022

The paper suggests that AI ethics should pay attention to morally relevant systemic effects of AI use. It draws the attention of ethicists and practitioners to systemic risks that have been neglected so far in professional AI-related codes of conduct, industrial standards and ethical discussions more generally. The paper uses the financial industry as an example to ask: how can AI-enhanced systemic risks be ethically accounted for? Which specific issues does AI use raise for ethics that takes systemic effects into account? The paper (1) relates the literature about AI ethics to the ethics of systemic risks to clarify the moral relevance of AI use with respect to the imposition of systemic risks, (2) proposes a theoretical framework based on the ethics of complexity and (3) applies this framework to discuss implications for AI ethics concerned with AI-enhanced systemic risks.
Frailty in Surgical Patients: Is it Relevant to Sexual Medicine?
Authors: Burns Ramzy T. , Bernie Helen L.
Published: January 2022

Background

As the age of our surgical population continues to rise, there is an increased need for adequate preoperative evaluation and risk stratification to ensure the best possible surgical outcomes for patients.

Aim

We sought to describe the 3 main models currently used to evaluate patient frailty and explore how they are being utilized in the field of surgery and sexual medicine.

Methods

We reviewed online resources including Pubmed with relevant search criteria centered around frailty, surgery, sexual medicine, and prosthetics.

Outcomes/Results

All relevant studies were reviewed and several models for patient frailty emerged; the Phenotype Model, the Frailty Index, the Clinical Frailty Scale, and the modified Frailty Index. Worse frailty indices were seen to be linked to higher rates of complications and mortalities postoperatively.

Clinical Implications

Although the adoption of patient frailty in the field of sexual medicine has been sluggish, few studies have shown that its use could help predict which patients are at increased risk of complications and may require more support when it comes to postoperative care and teaching.

Strength & Limitations

Overall there is a paucity of literature as it relates to sexual medicine and patient frailty and this paper provides a limited look at the usage of patient frailty in sexual medicine.

Conclusion

We implore all sexual health providers to begin to incorporate frailty metrics when caring for this population to help reduce postoperative complications and help better predict surgical success.
The Christian Invention of Time
Authors: Goldhill Simon
Published: January 2022

Time is integral to human culture. Over the last two centuries people's relationship with time has been transformed through industrialisation, trade and technology. But the first such life-changing transformation – under Christianity's influence – happened in late antiquity. It was then that time began to be conceptualised in new ways, with discussion of eternity, life after death and the end of days. Individuals also began to experience time differently: from the seven-day week to the order of daily prayer and the festal calendar of Christmas and Easter. With trademark flair and versatility, world-renowned classicist Simon Goldhill uncovers this change in thinking. He explores how it took shape in the literary writing of late antiquity and how it resonates even today. His bold new cultural history will appeal to scholars and students of classics, cultural history, literary studies, and early Christianity alike.
Ghosts and Religious Life in Early China
Authors: Poo Mu-Chou
Published: January 2022

For modern people, ghost stories are no more than thrilling entertainment. For those living in antiquity, ghosts were far more serious beings, as they could affect the life and death of people and cause endless fear and anxiety. How did ancient societies imagine what ghosts looked like, what they could do, and how people could deal with them? From the vantage point of modernity, what can we learn about an obscure, but no less important aspect of an ancient culture? In this volume, Mu-chou Poo explores the ghosts of ancient China, the ideas that they nurtured, and their role in its culture. His study provides fascinating insights into the interaction between the idea of ghosts and religious activities, literary imagination, and social life devoted to them. Comparing Chinese ghosts with those of ancient Egypt, Mesopotamia, Greece, and Rome, Poo also offers a wider perspective on the role of ghosts in human history.
Energy Conversion Engineering
Authors: Ghoniem Ahmed F.
Published: January 2022

This unique textbook equips students with the theoretical and practical tools needed to model, design, and build efficient and clean low-carbon energy systems. Students are introduced to thermodynamics principles including chemical and electrochemical thermodynamics, moving onto applications in real-world energy systems, demonstrating the connection between fundamental concepts and theoretical analysis, modelling, application, and design. Topics gradually increase in complexity, nurturing student confidence as they build towards the use of advanced concepts and models for low to zero carbon energy conversion systems. The textbook covers conventional and emerging renewable energy conversion systems, including efficient fuel cells, carbon capture cycles, biomass utilisation, geothermal and solar thermal systems, hydrogen and low-carbon fuels. Featuring numerous worked examples, over 100 multi-component homework problems, and online instructor resources including lecture slides, solutions, and sample term projects, this textbook is the perfect teaching resource for an advanced undergraduate and graduate-level course in energy conversion engineering.
Natural Disaster at the Closing of the Dutch Golden Age
Authors: Sundberg Adam
Published: January 2022

By the early eighteenth century, the economic primacy, cultural efflorescence, and geopolitical power of the Dutch Republic appeared to be waning. The end of this Golden Age was also an era of natural disasters. Between the late seventeenth and the mid-eighteenth century, Dutch communities weathered numerous calamities, including river and coastal floods, cattle plagues, and an outbreak of strange mollusks that threatened the literal foundations of the Republic. Adam Sundberg demonstrates that these disasters emerged out of longstanding changes in environment and society. They were also fundamental to the Dutch experience and understanding of eighteenth-century decline. Disasters provoked widespread suffering, but they also opened opportunities to retool management strategies, expand the scale of response, and to reconsider the ultimate meaning of catastrophe. This book reveals a dynamic and often resilient picture of a society coping with calamity at odds with historical assessments of eighteenth-century stagnation.
The Inheritors and The Nature of a Crime
Authors: Conrad Joseph , Saunders Max
Published: January 2022

This volume offers scholars the first authoritative text of two works produced collaboratively by two of the most important modern British novelists. Long hard to obtain and frequently neglected by critics, each can now be appreciated both in its own right and as part of the two authors' individual oeuvres. This scholarly edition situates both works in the context of the writers' meeting and ongoing collaboration, providing illuminating literary and historical references and detailing the works' composition history and reception in the UK and America. As well as establishing definitive texts of both works and of the authors' prefaces written for the 1924 republication of The Nature of a Crime, this edition also includes Ford's own 1924 account of his collaboration with Conrad on The Inheritors, as well as the text of Ford's 'The Old Story', a hitherto unpublished early draft of the basic plot of The Nature of a Crime.
The North American Antiepileptic Drug Pregnancy Registry: A Canadian Subgroup Analysis
Authors: Hébert Julien , Conant Susan N. , Holmes Lewis B. , Bui Esther
Published: January 2022

Background:

The North American AED Pregnancy Registry (NAAPR) provides crucial data for understanding the risks of antiepileptic drug (AED) exposure in pregnancy. This study aims to quantify the Canadian contribution to NAAPR and compare AED usage in pregnancy in Canada and the USA.

Methods:

Enrollment rate ratios (ERR) to NAAPR, adjusted for the populations of women of childbearing age, were calculated for the USA, Canada, and for the different Canadian provinces. Methods of enrollment to NAAPR and AED usage were compared between the two countries using chi-squared tests.

Results:

Between 1997 and 2019, 10,215 pregnant women enrolled into NAAPR: 4.1% were Canadian (n = 432, ERR = 0.39, CI95% = 0.35–0.43). Within Canada, no patients were enrolled from the three northern territories or from Prince Edward Island. While fewer patients than expected enrolled from Quebec (ERR = 0.35, CI95% = 0.19–0.58), Nova Scotia had the highest enrollment rate (ERR = 1.55; CI95% = 0.66–3.11). Compared with their American peers, Canadians were less likely to have been enrolled by their healthcare provider and more likely to have been enrolled via social media (p < 0.01). Canadian women were more likely to be taking carbamazepine (24% vs. 15%; p < 0.01) or valproic acid (8% vs. 4%; p < 0.01).

Conclusion:

The proportion of Canadian enrollees into NAAPR was less than expected based on the relative population size of Canadian women of reproductive age. Greater Canadian enrollment to NAAPR would contribute to ongoing worldwide efforts in assessing the risks of AEDs use in pregnant women and help quantify rates of AED usage, major congenital malformations, and access to subspecialized epilepsy care within Canada.
A negative charge at position D+5 of Motif A is critical for function of the major facilitator superfamily multidrug/H+antiporter MdtM – RETRACTED
Authors: Law Christopher J.
Published: January 2022

The phenomenon of antimicrobial resistance represents a major public health risk. The activity of integral membrane transporter proteins contributes to antimicrobial resistance in pathogenic bacteria and proton gradient-driven multidrug efflux representatives of the major facilitator superfamily (MFS) of secondary transporters are the dominant antimicrobial efflux proteins in Escherichia coli. In many, but not all, of the characterized MFS multidrug transporters, an aspartic acid residue at position D+5 of the conserved signature Motif A is essential for transport activity. The present work extends those studies to the E. coli MFS multidrug/H+ antiporter MdtM and used a combination of mutagenesis, expression studies, antimicrobial resistance assays, and transport activity measurements to reveal that a negatively charged residue at position D+5 is critical for MdtM transport function.
Pastoral Criticism, Structural Collaboration: The Role of Ecclesial Power Structures in Modernization and Economic Individualization
Authors: Minch Daniel
Published: January 2022

This article analyzes the complex processes of modernization and individualization, as well as how the church has structurally fostered individualization despite its public criticism. First, the article demonstrates how modernization and individualization have gradually restructured human self-understanding into an economic image of humanity: the human person ashomo oeconomicus. Second, this article examines the church's relation to modernity, and specifically its critiques of liberalism and economic individualism. However, the church has often generated the conditions and structures for individualization, and by extension the processes of acceleration and economization of the life-world that it criticizes. Three areas in intra-ecclesial discourse that foster individualization are examined: the interiorization of faith, ecclesial centralization and clerical bureaucracy, and the promotion of corporatism and digital immediacy. The article concludes by examining recent papal efforts at structural reform and the degree to which they address previously entrenched problems and point toward a renewed, non-economic anthropology.
The Covid pandemic enters the ballot box: The impact of conspiracy theories on Italians' voting behaviour during the COVID-19 crisis
Authors: Serani Danilo
Published: January 2022

The spread of the coronavirus disease-2019 (COVID-19) pandemic in 2020 was the impetus for an exogenous shock. In addition to the disruption brought on by the spread of COVID-19, conspiracy theories flourished on many aspects of the disease. However, the association between belief in conspiracy theories and voting behaviour has not been studied sufficiently, especially in the context of the COVID-19 pandemic. This paper investigates the association between a belief in conspiracy theories and an intention to vote for populist parties (PPs). This association is analysed in a case study of Italian voters, where PPs can be found in the government and in the opposition. By conducting a cross-sectional analysis during the third wave of panel data fielded in December 2020, this article shows that individuals who have anti-vax attitudes and who also have a higher propensity to believe in conspiracy theories are more likely to vote for PPs, although it is worth considering the roles PPs play in either the government or in the opposition.
A Cox model for gradually disappearing events
Authors: Jang Jiwook , Qu Yan , Zhao Hongbiao , Dassios Angelos
Published: January 2022

Innovations in medicine provide us longer and healthier life, leading lower mortality. Sooner rather than later, much greater longevity would be possible for us due to artificial intelligence advances in health care. Similarly, Advanced Driver Assistance Systems (ADAS) in highly automated vehicles may reduce or even eventually eliminate accidents by perceiving dangerous situations, which would minimize the number of accidents and lead to fewer loss claims for insurance companies. To model the survivor function capturing greater longevity as well as the number of claims reflecting less accidents in the long run, in this paper, we study a Cox process whose intensity process is piecewise-constant and decreasing. We derive its ultimate distributional properties, such as the Laplace transform of intensity integral process, the probability generating function of point process, their associated moments and cumulants, and the probability of no more claims for a given time point. In general, this simple model may be applicable in many other areas for modeling the evolution of gradually disappearing events, such as corporate defaults, dividend payments, trade arrivals, employment of a certain job type (e.g., typists) in the labor market, and release of particles. In particular, we discuss some potential applications to insurance.
Using a Chen-Stein identity to obtain low variance simulation estimators
Authors: Ross Sheldon M.
Published: January 2022

This paper is concerned with developing low variance simulation estimators of probabilities related to the sum of Bernoulli random variables. It shows how to utilize an identity used in the Chen-Stein approach to bounding Poisson approximations to obtain low variance estimators. Applications and numerical examples in such areas as pattern occurrences, generalized coupon collecting, system reliability, and multivariate normals are presented. We also consider the problem of estimating the probability that a positive linear combination of Bernoulli random variables is greater than some specified value, and present a simulation estimator that is always less than the Markov inequality bound on that probability.
Nutrition interventions addressing structural racism: a scoping review
Authors: Greene Matthew , Houghtaling Bailey , Sadeghzadeh Claire , De Marco Molly , Bryant De’Jerra , Morgan Randa , Holston Denise
Published: January 2022

African Americans experience high rates of obesity and food insecurity in part due to structural racism, or overlapping discriminatory systems and practices in housing, education, employment, health care and other settings. Nutrition education and nutrition-focused policy, systems and environmental changes may be able to address structural racism in the food environment. This scoping review aimed to summarise the available literature regarding nutrition interventions for African Americans that address structural racism in the food environment and compare them with the ‘Getting to Equity in Obesity Prevention’ framework of suggested interventions. An electronic literature search was conducted with the assistance of a research librarian encompassing six databases: MEDLINE, PyscINFO, Agricola, ERIC, SocINDEX and ProQuest Dissertations & Theses. A total of thirty sources were identified detailing interventions addressing structural barriers to healthy eating. The majority of nutrition interventions addressing structural racism consisted of policy, systems and/or environmental changes in combination with nutrition education, strategies focused on proximal causes of racial health disparities. Only two articles each targeted the ‘reduce deterrents’ and ‘improve social and economic resources’ aspects of the framework, interventions which may be better suited to addressing structural racism in the food environment. Because African Americans experience high rates of obesity and food insecurity and encounter structural barriers to healthy eating in the food environment, researchers and public health professionals should address this gap in the literature.
Vitamin D and depression in older adults: lessons learned from observational and clinical studies
Authors: Ceolin Gilciane , Antunes Luciana da Conceição , Moretti Morgana , Rieger Débora Kurrle , Moreira Júlia Dubois
Published: January 2022

Depression is a mental disorder triggered by the interaction of social, psychological and biological factors that have an important impact on an individual’s life. Despite being a well-studied disease with several established forms of treatment, its prevalence is increasing, especially among older adults. New forms of treatment and prevention are encouraged, and some researchers have been discussing the effects of vitamin D (VitD) on depression; however, the exact mechanism by which VitD exerts its effects is not yet conclusive. In this study, we aimed to discuss the possible mechanisms underlying the association between VitD and depression in older adults. Therefore, we conducted a systematic search of databases for indexed articles published until 30 April 2021. The primary focus was on both observational studies documenting the association between VitD and depression/depressive symptoms, and clinical trials documenting the effects of VitD supplementation on depression/depressive symptoms, especially in older adults. Based on pre-clinical, clinical and observational studies, it is suggested that the maintenance of adequate VitD concentrations is an important issue, especially in older adults, which are a risk population for both VitD deficiency and depression. Nevertheless, it is necessary to carry out more studies using longitudinal approaches in low- and middle-income countries to develop a strong source of evidence to formulate guidelines and interventions.
On the Lives of Modern State Law
Authors: Esmeir Samera
Published: January 2022

Modern state law is an expansive force that permeates life and politics. Law's histories—colonial, revolutionary, and postcolonial—tell of its constitutive centrality to the making of colonies and modern states. Its powers intertwine with life itself; they attempt to direct it, shape its most intimate spheres, decide on the constitutive line dividing public from private, and take over the space and time in which life unfolds. These powers settle in the present, eliminate past authorities, and dictate futures. Gendering and constitutive of sexual difference, law's powers endeavor to mold subjects and alter how they orient themselves to others and to the world. But these powers are neither coherent nor finite. They are ripe with contradictions and conflicting desires. They are also incapable of eliminating other authorities, paths, and horizons of living; these do not vanish but remain not only thinkable and articulable but also a resource for the living. Such are some of the overlapping and accumulative interventions of the two books under review: Sara Pursley's Familiar Futures and Judith Surkis's Sex, Law, and Sovereignty in French Algeria. What follows is an attempt to further develop these interventions by thinking with some of the books’ underlying arguments. Familiar Futures is a history of Iraq, beginning with the British colonial-mandate period and concluding with the 1958 Revolution and its immediate aftermath. Sex, Law, and Sovereignty is a history of “French Algeria” that covers a century of French colonization from 1830 to 1930. The books converge on key questions concerning how modern law and the modern state—colonial and postcolonial—articulated sexual difference and governed social and intimate life, including through the rise of personal-status law as a separate domain of law constitutive of the conjugal family. Both books are consequently also preoccupied with the relationship between sex, gender, and sovereignty. And both contain resources for living along paths not charted by the modern state and its juridical apparatus.
VESIcal: 2. A Critical Approach to Volatile Solubility Modeling Using an Open‐Source Python3 Engine
Authors: Wieser P. E. , Iacovino K. , Matthews S. , Moore G. , Allison C. M.
Published: January 2022

Accurate models of H2O and CO2 solubility in silicate melts are vital for understanding volcanic plumbing systems. These models are used to estimate the depths of magma storage regions from melt inclusion volatile contents, investigate the role of volatile exsolution as a driver of volcanic eruptions, and track the degassing path followed by a magma ascending to the surface. However, despite the large increase in the number of experimental constraints over the last two decades, many recent studies still utilize an earlier generation of models which were calibrated on experimental datasets with restricted compositional ranges. This may be because many of the available tools for more recent models require large numbers of input parameters to be hand‐typed (e.g., temperature, concentrations of H2O, CO2, and 8–14 oxides), making them difficult to implement on large datasets. Here, we use a new open‐source Python3 tool, VESIcal, to critically evaluate the behaviors and sensitivities of different solubility models for a range of melt compositions. Using literature datasets of andesitic‐dacitic experimental products and melt inclusions as case studies, we illustrate the importance of evaluating the calibration dataset of each model. Finally, we highlight the limitations of particular data presentation methods, such as isobar diagrams, and provide suggestions for alternatives, and best practices regarding the presentation and archiving of data. This review will aid the selection of the most applicable solubility model for different melt compositions, and identifies areas where additional experimental constraints on volatile solubility are required.
Impact of Soil Moisture on Afternoon Convection Triggering Over the Tibetan Plateau Based on 1‐D Boundary Layer Model
Authors: Zhao Cailing , Meng Xianhong , Li Yueqing , Lyu Shihua , Guo Jianping , Liu Huizhi
Published: January 2022

The impact of soil moisture conditions on the triggering of afternoon convection over the Tibetan Plateau (TP) was investigated by applying the convective triggering potential (CTP) and humidity index framework developed by Findell and Eltahir (2003a, https://doi.org/10.1175/1525-7541(2003)004<0552:acosml>2.0.co;2, 2003b, https://doi.org/10.1175/1525-7541(2003)004<0570:acosml>2.0.co;2) using a slab model. Atmospheric sounding observations from May to September from 2015 to 2019 from 16 sites were used for the diagnosis. The results showed that the thresholds of CTP and humidity index in the lower‐layer atmosphere (HIlow) are distinct from other regions such as the United States and India, suggesting an easier triggering potential for the TP due to its high altitude induced lower air density and higher buoyancy. The convection over the TP is mainly affected by the atmospheric background. The percentages of soil moisture‐controlled cases is close to 50% mainly located in the broadly central TP. In addition, the positive feedback is mainly located in the center of the TP. Negative feedback appears in the southwest of the TP. Soil moisture is the most critical factor for precipitation triggering in soil moisture‐precipitation feedback, while wind speed can also have certain influences. The impact of soil moisture on different outcomes has no significant correlation with land surface elevation differences. Negative feedback in the southwest of the TP appeals to a necessary enhancement requirement for sounding observations in the western TP.
Regional and Local Patterns of Upper‐Plate Deformation in Cascadia: The Importance of the Down‐Dip Extent of Locking Relative to Upper‐Plate Strength Contrasts
Authors: McKenzie K. A. , Furlong K. P. , Herman M. W.
Published: January 2022

The details of subduction zone locking place constraints on the characteristics of megathrust events. Due to the lack of significant present‐day seismicity along the Cascadia subduction interface, geodetic data are used to assess subduction locking along the margin. We isolate the subduction signal from other tectonic signals within the Cascadia GPS field, to assess the details of plate‐interface locking. Apparent coupling determined by a simple homogenous elastic half‐space inversion cannot everywhere reproduce the subduction component of the GPS field. Consequently, we explore the relationships among upper‐plate strength, locking depth and the resulting surface velocity signal using 2D finite element models. When the upper plate is composed of a weak material, trenchward of a strong backstop, we find that the down‐dip limit of locking relative to the location of the weak‐to‐strong transition controls how upper‐plate deformation is spatially distributed. If locking extends into the stronger material, as observed in central Cascadia, the surface velocity field propagates farther inland than expected from a simple homogeneous elastic model. In contrast, in southern Cascadia, because locking terminates within the weak accretionary margin, upper‐plate shortening is localized within the weaker material, particularly in the region between the end of locking and the strong Klamath terrane. This behavior provides a possible mechanism for producing the high (geodetic and permanent) uplift rates, plate‐motion‐parallel shortening, and crustal exhumation observed in many active and fossil subduction zones.
Referral Outcomes From a Neurocognitive Screening Program for Pediatric Sickle Cell Disease
Authors: Karst Jeffrey S. , Miller Meghan , Heffelfinger Amy K. , Newby Robert F. , Scott J. Paul
Published: January 2022

Objective:

Pediatric sickle cell disease (SCD) is associated with neurocognitive and academic impairment. However, not all patients receive appropriate educational or therapeutic services. It is important to identify patients at risk of academic or psychosocial difficulties and make appropriate referrals. This article explores referrals made from a screening program within a comprehensive SCD clinic.

Method:

All patients seen at the clinic were eligible for participation in the screening program. Patients ( N = 61) cross three age cohorts (i.e., age 6 to 7, age 11 to 12, and age 15 to 16) consented to research participation. Participants completed a 1-hr screening that included cognitive, academic, attention, and parent-report measures of behavior and executive functioning and caregiver and patient interviews.

Results:

Parents reported concerns across academic and learning domains, and performance on clinical measures suggested a high rate of patients at least one standard deviation below normative means. Following screening, 48% of patients were referred for additional support services via an existing Section 504 Plan/IEP, whereas 18% more were recommended to have a plan implemented. Of the participants, 41% were referred for further evaluation or counseling, whereas 26% were diagnosed with attention-deficit/hyperactivity disorder or had an existing diagnosis confirmed.

Conclusions:

Neurocognitive screening in SCD is essential. Participants in this program demonstrated challenges across many domains and received a broad range of recommendations and referrals. Problems were identified above and beyond parent-report concerns. Future research should identify incremental value of specific measures used and whether additional tiers of screening are necessary.

Implications for Impact Statement

This article reports on a neurocognitive screening program for children with Sickle Cell Disease. Results suggest that a brief screening, implemented within a clinic screening is feasible and beneficial to patients. Recommendations for implementation are provided and may be applicable to other pediatric disease groups as well.
Climate change extreme and seasonal toxic metal occurrence in Romanian freshwaters in the last two decades—case study and critical review
Authors: Iordache Andreea Maria , Nechita Constantin , Voica Cezara , Pluháček Tomáš , Schug Kevin A.
Published: January 2022

The relationship between metal levels in the Olt River ecosystem in southern Romania (measured during 2018‒2019, with 1064 sediment and water samples) and daily climate data were explored to assess the need for targeted source identification and mitigation strategies. In 2018, there was a strong relationship between the sediment Pb, As, Cd, and Hg contents and temperature (r > 0.8, p < 0.001). Mercury in sediments had a positive correlation with precipitation, and Hg in the water correlated with minimum temperature in May 2018 (p < 0.01). In July 2019, heavy metals were positively correlated with precipitation and negatively correlated with temperature. According to nonsymmetrical correspondence analysis, the four climate parameters analyzed were linearly correlated with the frequency of metal detection (p < 0.001) in both years. The statistical analysis showed strong relationships between heavy metal levels and climatic factors and attributed the discrepancies in elemental concentrations between 2018 and 2019 to climate warming.
Scalable and selective deuteration of (hetero)arenes
Authors: Li Wu , Rabeah Jabor , Bourriquen Florian , Yang Dali , Kreyenschulte Carsten , Rockstroh Nils , Lund Henrik , Bartling Stephan , Surkus Annette-Enrica , Junge Kathrin , Brückner Angelika , Lei Aiwen , Beller Matthias
Published: January 2022

Isotope labelling, particularly deuteration, is an important tool for the development of new drugs, specifically for identification and quantification of metabolites. For this purpose, many efficient methodologies have been developed that allow for the small-scale synthesis of selectively deuterated compounds. Due to the development of deuterated compounds as active drug ingredients, there is a growing interest in scalable methods for deuteration. The development of methodologies for large-scale deuterium labelling in industrial settings requires technologies that are reliable, robust and scalable. Here we show that a nanostructured iron catalyst, prepared by combining cellulose with abundant iron salts, permits the selective deuteration of (hetero)arenes including anilines, phenols, indoles and other heterocycles, using inexpensive D2O under hydrogen pressure. This methodology represents an easily scalable deuteration (demonstrated by the synthesis of deuterium-containing products on the kilogram scale) and the air- and water-stable catalyst enables efficient labelling in a straightforward manner with high quality control.
Unique mobile elements and scalable gene flow at the prokaryote–eukaryote boundary revealed by circularized Asgard archaea genomes
Authors: Wu Fabai , Speth Daan R. , Philosof Alon , Crémière Antoine , Narayanan Aditi , Barco Roman A. , Connon Stephanie A. , Amend Jan P. , Antoshechkin Igor A. , Orphan Victoria J.
Published: January 2022

Eukaryotic genomes are known to have garnered innovations from both archaeal and bacterial domains but the sequence of events that led to the complex gene repertoire of eukaryotes is largely unresolved. Here, through the enrichment of hydrothermal vent microorganisms, we recovered two circularized genomes of Heimdallarchaeum species that belong to an Asgard archaea clade phylogenetically closest to eukaryotes. These genomes reveal diverse mobile elements, including an integrative viral genome that bidirectionally replicates in a circular form and aloposons, transposons that encode the 5,000 amino acid-sized proteins Otus and Ephialtes. Heimdallaechaeal mobile elements have garnered various genes from bacteria and bacteriophages, likely playing a role in shuffling functions across domains. The number of archaea- and bacteria-related genes follow strikingly different scaling laws in Asgard archaea, exhibiting a genome size-dependent ratio and a functional division resembling the bacteria- and archaea-derived gene repertoire across eukaryotes. Bacterial gene import has thus likely been a continuous process unaltered by eukaryogenesis and scaled up through genome expansion. Our data further highlight the importance of viewing eukaryogenesis in a pan-Asgard context, which led to the proposal of a conceptual framework, that is, the Heimdall nucleation–decentralized innovation–hierarchical import model that accounts for the emergence of eukaryotic complexity.
Intracranial electrophysiological recordings from the human brain during memory tasks with pupillometry
Authors: Cimbalnik Jan , Dolezal Jaromir , Topçu Çağdaş , Lech Michal , Marks Victoria S. , Joseph Boney , Dobias Martin , Van Gompel Jamie , Worrell Gregory , Kucewicz Michal
Published: January 2022

Data comprise intracranial EEG (iEEG) brain activity represented by stereo EEG (sEEG) signals, recorded from over 100 electrode channels implanted in any one patient across various brain regions. The iEEG signals were recorded in epilepsy patients (N = 10) undergoing invasive monitoring and localization of seizures when they were performing a battery of four memory tasks lasting approx. 1 hour in total. Gaze tracking on the task computer screen with estimating the pupil size was also recorded together with behavioral performance. Each dataset comes from one patient with anatomical localization of each electrode contact. Metadata contains labels for the recording channels with behavioral events marked from all tasks, including timing of correct and incorrect vocalization of the remembered stimuli. The iEEG and the pupillometric signals are saved in BIDS data structure to facilitate efficient data sharing and analysis.