bluuebunny/crossref_metadata_2025 huggingface dataset:
Scientific landscape and visualization analysis of the link between adenomyosis and infertility from 2000 to 2024
Authors: Yang Qiaomei , Zheng Xinye , Zhong Fuchun , Chen Li , Hong Jingxuan , Liu Xianhua , Jiang Junying
Published: February 2025

Objectives

Adenomyosis (AM) is a chronic disorder that significantly impacts women’s health and quality of life worldwide, particularly by causing progressive impairment in fertility. This study aimed to summarize and visualize the literature concerning AM-associated infertility using scientometric analysis.

Methods

We conducted a literature search in the Web of Science™ Core Collection (WoSCC) database for “adenomyosis” and “infertility” as topics from 2000 to 2024. The collected data were organized in Microsoft Office Excel for further analysis. Bibliometric analyses and visualizations were performed using Origin, CiteSpace, VOSviewer, and the Bibliometrix package.

Results

A total of 456 articles were published across 153 journals, reflecting a growing trend in both published and cited articles. The scholars with the highest output were Petraglia F., Chapron C., and Pellicer A., while the Fertility and Sterility were the most publications’ journal. China, the United States, and Italy ranked as the top three countries globally regarding relevant publications worldwide. The 190 keywords in the literature were divided into eight clusters primarily related to pathogenesis, adverse factors affecting pregnancy, treatment methods, diagnostic methods, disease progression, in vitro fertilization (IVF) management, infertility in women, and fertility management. Current hotspots in this field include investigating potential mechanisms of pathogenesis, diagnostic strategies, and improving pregnancy outcomes for patients with AM-associated infertility.

Conclusion

This study highlights that infertility is the most significant and complex issue associated with AM. Although chronic disease management strategies, pharmacological treatments, and assisted reproductive technologies (ART) have improved fertility outcomes in women with AM, further clinical translational research is still warranted.
Effect of polyhexamethylene biguanide-coated central venous catheters on bacterial colonization in cancer patients undergoing abdominal surgery: a randomized controlled trial
Authors: Dong Jun , Yang Yong , Li Qi , Xu Jia-Xuan , Shen Yan-Fen , Wang Hong-Zhi
Published: February 2025

Background

Central venous catheters (CVCs) are widely used in critically ill patients, including cancer patients, but are associated with complications such as catheter-related bloodstream infections (CRBSIs). This study evaluates the effectiveness of polyhexamethylene biguanide (PHMB)-coated CVCs in reducing catheter-tip bacterial colonization in cancer patients undergoing abdominal surgery.

Methods

A prospective, randomized, monocentric clinical trial was conducted at Peking University Cancer Hospital from March 2017 to April 2019. Surgical cancer patients requiring CVCs were randomized into two groups: a PHMB-coated CVC group (Certofix® protect) and a standard CVC group (Certofix®). The primary outcome was catheter tip bacterial colonization, and the secondary outcomes included catheter retention time and hospital length of stay.

Results

A total of 1,185 patients were included in the analysis. The incidence of catheter tip bacterial colonization was 2.5% in the PHMB-coated group and 4.2% in the standard CVC group (p = 0.10). Hospital length of stay was significantly shorter in the PHMB-coated group (p < 0.001). Subgroup analysis showed reduced bacterial colonization in male patients in the PHMB-coated group (p = 0.04).

Conclusion

Polyhexamethylene biguanide-coated CVCs did not significantly reduce catheter tip bacterial colonization in the overall population but showed a beneficial effect in male cancer patients undergoing abdominal surgery. In clinical practice, it is necessary to consider various factors when selecting the type of catheter.

Clinical trial registration

No. chiCTR-IPR-16010027.
Efficacy of adding mobilization and balance exercises to a home-based exercise program in patients with ankle disability: a randomized controlled trial
Authors: Eladl Hadaya Mosaad , Elsherbini Dalia Mahmoud Abdelmonem , Elshorbagy Radwa T. , Ibrahim Ateya Megahed , El-Sherbiny Mohamed , Ibrahim Sherief El-Sayed Abd El-Farrag , Elfayoumi Ghada Ibrahim Fahmi , Aboonq Moutasem Salih , Elbastawisy Yasser M. , Salama Mohamed El-Dosoky Mohamed , Allam Nesma M.
Published: February 2025

Background

Ankle joint fractures account for 10.2% of all fractures. It has been hypothesized that mobilizing the ankle joint is a crucial intervention for improving balance and range of motion (ROM).

Objective

The current study explores the impact of incorporating mobilization, balance training, and physical therapy exercises into a home-based program on pain, ROM, health-related quality of life (HRQoL), and peak muscle torque in patients with ankle disability following road traffic accidents (RTAs).

Methods

In this single-blinded, randomized controlled trial, 60 participants with post-RTA ankle disability were randomly assigned to either the experimental group or the control group. The experimental group underwent home-based exercises combined with mobilization, balance training, and physical therapy for 2 months, while the control group followed only a home exercise program. The interventions were then implemented 3 days per week. Pain was evaluated using the Visual Analogue Scale (VAS), ankle ROM was measured using a universal goniometer, HRQoL was evaluated using the Short Form (SF 36) survey, and peak torque was assessed using the Biodex System isokinetic dynamometer.

Results

Significant improvements were observed in the experimental group compared to the control group in pain, ROM, HRQoL, and peak muscle torque (p < 0.001). After 8 weeks, the experimental group outcomes for VAS, ROM of ankle dorsiflexion/plantarflexion (DF/PF), peak torque of DF/PF, and HRQoL physical and mental component summaries (PCS and MCS) were 2.55 ± 0.22, 13.02 ± 0.38, 25.06 ± 0.40, 34.12 ± 0.81, 47.46 ± 0.90, 43.15 ± 0.78, and 45.01 ± 0.68, respectively. In contrast, the results of the control group were 5.98 ± 0.31, 6.16 ± 0.28, 14.97 ± 0.35, 26.17 ± 0.90, 41.38 ± 0.94, 33.05 ± 1.10, and 34.52 ± 1.06, respectively.

Conclusion

Incorporating mobilization and balance exercises into a physical therapy program significantly improves pain, ankle ROM, HRQoL, and muscle torque (DF/PF) in patients with ankle disability following RTAs.

Clinical trial registration

ClinicalTrials.gov, identifier NCT06010706.
The impact of allergic contact dermatitis on the inflammatory response and repair in wound healing process
Authors: Zhang Wei , Xu Jiabao , Qu Songyan , Peng Hui
Published: February 2025

Background

Skin trauma and the subsequent wound healing process present significant challenges for healthcare systems and patients globally. Allergic contact dermatitis (ACD) was a delayed-type hypersensitivity reaction that can disrupt the normal wound repair process due to prolonged inflammation and immune dysregulation. However, the specific impact of ACD on the inflammatory response and repair in wound healing remains incompletely understood. This study aimed to investigate the influence of ACD on the inflammatory response and repair during the wound healing process.

Methods

This study was a retrospective cohort study. A total of 120 patients with skin trauma treated at Henan Provincial People’s Hospital from January 2023 to December 2023 were included. There were 69 cases of control and 51 cases of ACD. Inclusion and exclusion criteria were defined, and various indicators, including patient data, inflammatory factors, cell detection, and wound healing assessment, were measured and analyzed using appropriate statistical methods.

Results

The study revealed significant differences between the control and ACD groups. ACD was associated with higher levels of TNF-α, IL-6, IL-1β, C-reactive protein, and IL-8 compared to control (p < 0.05). Additionally, ACD group exhibited increased counts of macrophages, neutrophils, T lymphocytes, B lymphocytes, and mast cells compared to the control group (p < 0.05). Moreover, ACD was linked to delayed wound closure time and differences in the distribution of healing degrees (p < 0.05). Correlation analysis indicated significant associations among ACD, inflammatory markers, cellular responses, wound closure time, and healing degree (p < 0.05).

Conclusion

The study demonstrates that ACD exerts a substantial impact on the inflammatory response, cellular components, and wound healing parameters in the context of skin trauma. The heightened levels of inflammatory markers, altered cellular responses, and delayed wound closure observed in ACD patients underscore the need for targeted interventions tailored to optimize wound repair in this population.
Seasonal dynamics of bacterial communities in mangrove sediments of Shupaisha island, Zhejiang Province, China
Authors: He Maoqiu , Jiang Shoudian , Li Xiangfu , Yao Liqin , Shui Bonian
Published: February 2025

Mangrove forests, found primarily in tropical and subtropical coastal regions, support diverse microbial communities that are crucial for nutrient cycling and energy flow and then sustain mangrove ecosystem integrity. This study investigated the seasonal dynamics of bacterial communities in mangrove sediments of Shupaisha island (Zhejiang Province, China) through amplifying and high-throughput sequencing bacterial 16S rRNA gene fragments. Proteobacteria (23.59–44.40%), Actinobacteria (4.92–19.01%), and Bacteroidetes (4.31–22.79%) dominated the bacterial phyla in Shupaisha mangrove sediments with the highest diversity indices in winter. Actinobacteria were more abundant during winter (13.27%) and spring (14.36%), while Bacteroidetes abundance was highest in summer, significantly correlating with temperature. Significant differences in bacterial community composition were observed between winter and summer, while spring and autumn exhibited similar distribution, indicating a transitional pattern in bacterial community dynamics, with temperature and sand content being the most influential factors. This study enhances our understanding of the seasonal characteristics of bacterial communities in the mangrove ecosystems, potentially providing valuable insights into monitoring and assessing the health and stability of mangrove ecosystems in Zhejiang Province.
Ayahuasca partially preserves striatal integrity in juvenile non-human primates exposed to chronic stress: evidence from stereological evaluation
Authors: de Lira-Bandeira Wigínio Gabriel , de Mendonça Batista Lílian Andrade Carlos , de Medeiros Bandeira Andréa Silva , de Góis Morais Paulo Leonardo Araújo , Pereira Luiz Roberto Fernandes , de Meiroz Grilo Maria Lara Porpino , Cavalcante Jeferson Souza , de Santana Melquisedec Abiaré Dantas , de Lima Ruthnaldo Rodrigues Melo , Galvão-Coelho Nicole Leite , Ladd Fernando Vagner Lobo , do Nascimento Expedito Silva
Published: February 2025

Introduction

The striatum (St) integrates cognitive, motor, and limbic functions and plays a critical role in processing emotions, motivation, and rewards. It may undergo several morphophysiological changes in neuropsychiatric diseases. Depression, a complex psychiatric disorder, affects millions of people around the world and leads to an increased risk of suicide, decreased quality of life, and functional impairment. Conventional treatments require prolonged use, leading to drug resistance; thus, new treatments and therapeutic strategies have been widely studied. Ayahuasca results from the joint infusion of the Banisteriopsis caapi vine and Psychotria viridis leaves have psychoactive properties, and its use in depression has shown promising results. Our objective was to morphoquantitatively evaluate the effects of ayahuasca on the St in an already validated model of juvenile depression induced in a non-human primate.

Methods

Six marmosets were divided into three groups of two animals each. One group was kept in family life (FG), and two groups were socially isolated (IG). Isolation was carried out by separating the animal from all others in the colony. One of the isolated groups received doses of ayahuasca tea (AG) 3 days before and two times during the isolation period, while the other groups received the same dose of placebo. After 13 weeks of experimentation, euthanasia, and transcardiac perfusion were performed. The brains were sectioned and stained with thionin using the Nissl method. We employed stereological techniques to assess the striatum and investigate potential alterations in neuronal volume in socially isolated animals treated with ayahuasca. Equidistant sections of the caudate and putamen were analyzed for all measurements and selected by systematic and uniform sampling.

Results and discussion

Striatal neurons in the IG group exhibited significantly smaller volumes compared to those in the FG and AG groups. Our findings suggest that ayahuasca may prevent extensive neuronal volume loss, as observed in the IG, by acting as a prophylactic agent and buffering neural structural changes during chronical social isolation.
Introducing the “urine biochemical approach”: an alternative tool for improving acute kidney injury monitoring in critically ill patients
Authors: Maciel Alexandre Toledo
Published: February 2025

Urine electrolytes and indices assessment as a tool for acute kidney injury (AKI) pathophysiological understanding and management is, until these days, a matter of debate. The classic division of AKI in “pre-renal” (functional/transient) and “renal” (structural/persistent) based on the urinary concentration of sodium and the fractional excretions of sodium and urea has gained popularity for decades and is still present in medical textbooks. Nevertheless, the conclusions of the studies that have used these parameters are very heterogenous and controversial. In the last decade, the pre-renal paradigm has been questioned since urine biochemistry (UB) compatible with “pre-renal AKI” was retrieved from experimental animals with increased renal blood flow, leading some authors to conclude that this approach is not useful for AKI monitoring. Our group has also studied the use of UB in AKI and we think that the key point for adequate use of this tool in clinical practice is a complete mindset change in the way we look and interpret data. In this article, we present the “urine biochemical approach” as an alternative way for UB assessment, which we believe that makes more sense and seems to be more useful for AKI monitoring than the traditional approach. Although the real utility of this alternative approach needs to be confirmed in large, prospective studies, the aim of the present article is to open the mind of critical care practitioners for a potential reappraisal of ancient concepts and ideas regarding the use of urine electrolytes in AKI monitoring.
A signature combining brain functional connectivity with executive and motor function for general cognitive decline in Parkinson’s disease
Authors: Wang Jin , Shu Zhilin , Wang Yue , Lu Jiewei , Zhang Xinyuan , Cheng Yuanyuan , Yu Yang , Han Jianda , Zhu Zhizhong , Yu Ningbo , Wu Jialing
Published: February 2025

Introduction

Cognitive decline is common in Parkinson’s disease (PD). Reliance on neuropsychological testing alone can lead to delayed identification, and an objective and comprehensive approach is needed in clinical practice. We assessed brain functional connectivity during PD-MCI (mild cognitive impairment) and PD-NC (normal cognition) patients, and healthy controls (HC) completing the Stroop color-word test (SCWT) using functional near-infrared spectroscopy (fNIRS), and explored the predictive value of combining relevant brain function and behavioral information for general cognitive decline in PD.

Methods

Nineteen patients with PD-MCI, 21 with PD-NC and 33 age-matched HC were recruited. Group differences in executive performance and prefrontal functional connectivity were analyzed. Receiver operating characteristic analysis was used to measure the value of combining brain functional connectivity with executive and motor function in predicting PD-MCI.

Results

During the color-word incongruent test, PD-MCI patients had significantly lower correct rate than HC and PD-NC patients. Meanwhile, PD-MCI patients exhibited significantly increased regional strength of the left and right prefrontal cortex (RSl, RSr), and global efficiency than HC, and compared with PD-NC, PD-MCI patients showed significantly higher RSr. For PD patients, MMSE score and correct rate during the color-word incongruent test were negatively associated with the RSr after adjusting for education level and age. After combined the RSr, correct rate and MDS-UPDRS III score, diagnostic sensitivity and specificity of PD-MCI reached 0.737 and 0.810, respectively, with an area under the curve of 0.830.

Conclusion

We proposed a signature combining brain functional connectivity with executive and motor function for general cognitive decline in PD, which could provide new insights into early detection and intervention of this problem.
Wearable sensors and machine learning fusion-based fall risk prediction in covert cerebral small vessel disease
Authors: Zhou Yuanyuan , Zhang Dingwen , Ji Yingxiao , Bu Shuohan , Hu Xinzhu , Zhao Congying , Lv Zhou , Li Litao
Published: February 2025

Background

Fall risk prediction is crucial for preventing falls in patients with cerebral small vessel disease (CSVD), especially for those with gait disturbances. However, research in this area is limited, particularly in the early, asymptomatic phase. Wearable sensors offer an objective method for gait assessment. This study integrating wearable sensors and machine learning, aimed to predict fall risk in patients with covert CSVD.

Methods

We employed soft robotic exoskeleton (SRE) to acquire gait characteristics and surface electromyography (sEMG) system to collect sEMG features, constructing three datasets: gait-only, sEMG-only, and their combination. Using Support Vector Machine (SVM), Random Forest (RF), Gradient Boosting Decision Tree (GBDT), and Neural Network (NN) algorithms, we developed twelve predictive models. Furthermore, we integrated the selected baseline data and imaging markers with the three original datasets to create three new integrated datasets, and constructed another twelve optimized predictive models using the same methods. A total of 117 participants were enrolled in the study.

Results

Of the 28 features, ANOVA identified 10 significant indicators. The Gait & sEMG integration dataset, analyzed using the SVM algorithm, demonstrated superior performance compared to other models. This model exhibited an area under the curve (AUC) of 0.986, along with a sensitivity of 0.909 and a specificity of0.923, reflecting its robust discriminatory capability.

Conclusion

This study highlights the essential role of gait characteristics, electromyographic features, baseline data, and imaging markers in predicting fall risk. It also successfully developed an SVM-based model integrating these features. This model offers a valuable tool for early detection of fall risk in CSVD patients, potentially enhancing clinical decision-making and prognosis.
IsoFoodTrack: a comprehensive database and management system based on stable isotope ratio analysis for combating food fraud
Authors: Terro Cathrine , Modic Robert , Ogrinc Matevž , Simčič Andraž , Drole Jan , Eftimov Tome , Koroušić Seljak Barbara , Ogrinc Nives
Published: February 2025

The IsoFoodTrack database is a comprehensive, scalable, and flexible platform designed to manage isotopic and elemental composition data for a wide range of food commodities. It supports research in food authenticity and fraud detection by integrating isotopic data with rich metadata, including geographical, production, and methodological details. The database is built for scalability, allowing the addition of new commodities, analytical methods, and metadata fields, while ensuring interoperability with external databases through standardized formats and API integration. Based on the data collected in IsoFoodTrack using statistical, chemometric and machine learning approaches it has a capability to identify and classify the origin of food commodities. IsoFoodTrack also supports isotope mapping (isoscapes), providing spatially continuous predictions that enhance the detection of food fraud. Rigorous quality control measures ensure high data reliability, and the user-friendly web interface facilitates easy access and visualization. Openly accessible through platforms like National Center for Biomedical Ontology (NCBO) BioPortal, IsoFoodTrack is positioned for future expansion and integration of open-access data, making it a vital tool for researchers and regulatory agencies in ensuring food authenticity and traceability.
Association between relative fat mass and gallstones: a cross-sectional study based on NHANES 2017–2020
Authors: Gao Chaofeng , Li Yanan , Ren Xuan , Han Wei
Published: February 2025

Background

Gallstones are a common gastrointestinal disease worldwide, associated with significant public health burdens. Obesity and fat distribution are recognized as major risk factors for gallstone formation, yet traditional anthropometric indices such as BMI and WC have limitations in reflecting fat distribution and its metabolic consequences. Relative Fat Mass (RFM), a novel anthropometric index, may provide more accurate predictions of gallstone risk, but its association with gallstone formation remains underexplored.

Methods

This study utilized data from NHANES 2017–2020, including 6,084 participants aged ≥20 years, to investigate the relationship between RFM and gallstone risk. Multivariable logistic regression and smooth curve fitting were used to assess this association. RFM’s predictive ability was compared with traditional indices using ROC and decision curve analysis (DCA). LASSO regression and AIC-based multivariable regression were employed to construct a gallstone risk prediction model.

Results

Each one-unit increase in RFM was associated with a 11% higher risk of gallstones (OR: 1.11; 95% CI: 1.08–1.13). The smooth curve fitting revealed a linear relationship between RFM and gallstones. RFM demonstrated superior predictive ability (AUC = 0.705) compared to BMI, WC, WWI, and BRI. The predictive model, incorporating age, RFM, diabetes, waist circumference, and alcohol consumption, achieved good performance (AUC = 0.738) with sensitivity and specificity of 70 and 66%, respectively.

Conclusion

RFM is strongly associated with gallstone risk and outperforms traditional anthropometric measures in risk prediction. The study presents a model that serves as a useful instrument for recognizing populations at elevated risk and facilitating focused interventions, especially among those with a prevalent occurrence of obesity and metabolic disturbances. These findings support the potential of RFM as an effective measure in clinical and public health settings for reducing the burden of gallstone-related diseases.
Clinical value of the nomogram model based on endoscopic ultrasonography radiomics and clinical indicators in identifying benign and malignant lesions of the pancreas
Authors: Fan Xiaofei , Huang Jia , Cai Xiaohan , Maihemuti Ayixie , Li Shu , Fang Weili , Wang Bangmao , Liu Wentian
Published: February 2025

Objective

Based on endoscopic ultrasonography (EUS) radiomics and clinical data, we constructed a radiomics model and a nomogram model for identifying benign and malignant pancreatic lesions, and explored the diagnostic performance of these two prediction models.

Methods

Images and clinical data of 151 patients with pancreatic lesions detected by EUS from January 2018 to September 2023 were retrospectively collected. The patients were randomly divided into a training set and a validation set at a ratio of 7:3. Through feature extraction and feature screening of EUS images, we calculated the radiomics score (rad-score) to realize the construction of the radiomics model. Collecting the clinical data, laboratory test results, and rad-scores from patients, univariate and multivariate logistic regression analyses were used to screen statistically significant influencing factors that could help identify benign and malignant lesions of the pancreas, and a nomogram model was constructed. The diagnostic performance and clinical utility of the two prediction models were evaluated using the receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).

Results

Through feature extraction and screening, eight non-zero coefficient features were finally selected to calculate the rad-score. Multivariate logistic regression analysis showed that rad-score, age, and CA199 were the influencing factors in predicting benign and malignant pancreatic lesions. A nomogram model was constructed based on the three factors. In the validation set, the nomogram model exhibited superior performance with an AUC = 0.865 (95% CI 0.761–0.968) compared to the radiomics prediction model. The calibration curve and DCA depicted that the nomogram model demonstrated superior accuracy and yielded a higher net benefit for clinical decision-making compared to the radiomics prediction model.

Conclusion

Based on EUS radiomics and clinical indicators, we constructed a promising nomogram model to accurately identify benign and malignant pancreatic lesions.
Assessment of non-tumor liver parenchyma damage in advanced gastric cancer treatment with transarterial infusion chemotherapy: a study using imaging and hepatic injury indicators
Authors: Jing Yifan , Jing Jian , Sun Xiaokang , Jin Yong , Bai Xuming
Published: February 2025

Introduction

This study aimed to evaluate non-tumor liver parenchymal injury in advanced gastric cancer patients undergoing transarterial infusion chemotherapy (TAI) using imaging parameters and liver injury biomarkers, providing objective evidence for early detection of drug-induced liver injury.

Methods

A retrospective analysis was conducted on 52 advanced gastric cancer patients who received TAI at our center from July 2015 to July 2023. Abdominal CT images and laboratory data were collected before and after treatment. Imaging postprocessing software was used to measure the liver-to-spleen (L/S) attenuation ratio and spleen volume. Liver fibrosis indices (APRI, FIB-4) and liver function scores (Child-Pugh, ALBI) were calculated. Statistical analysis included Wilcoxon rank-sum test and paired t-test for pre- and post-treatment comparisons.

Results

Patients received an average of 2.80 TAI cycles over 8.3 weeks. Post-treatment, 76.92% (40/52) showed a significant reduction in L/S attenuation ratio (1.23 ± 0.13 vs. 1.12 ± 0.1, P < 0.01), and 73.1% (38/52) exhibited increased spleen volume (151,219.33 mm³ vs. 202, 171.32 mm³, P < 0.01). Liver fibrosis indices significantly increased: APRI (0.19 ± 0.15 vs. 0.37 ± 0.27) and FIB-4 (1.29 ± 0.88 vs. 2.24 ± 1.38) (P < 0.01). No significant changes were observed in ALBI (-2.7 ± 0.41 vs. -2.58 ± 0.43) or Child-Pugh scores (5.31 ± 0.47 vs. 5.38 ± 0.64) (P > 0.05).

Discussion

Transarterial infusion chemotherapy for advanced gastric cancer results in short-term damage to the non-tumor liver parenchyma, with imaging findings showing hepatic steatosis (reduction in L/S ratio) and splenomegaly. Serum markers suggest progression of hepatic fibrosis, consistent with the pathological features of hepatic sinusoidal obstruction syndrome. The combination of CT imaging and APRI/FIB-4 provides a sensitive method for detecting subclinical liver injury, reflecting pathological changes earlier than traditional liver function scores.
Impact of foreign players’ participation in the Palestinian basketball league on team cohesion from the perspective of local players
Authors: Yousef Iyad A. , Kayed Mahmoud W. , Liftawi Sana M.
Published: February 2025

Objective

The purpose of this paper is to assess the impact of foreign players’ participation in the Palestinian Basketball League on team cohesion from the perspective of local players.

Methods

Using a descriptive-analytical method, the researchers developed a cohesion measurement tool with three dimensions: psychological, social, and team belonging. The tool comprised 30 items, equally distributed across the dimensions, based on player status, experience, and position. The study surveyed 84 players aged between 18 and 38 in the Palestinian Basketball League.

Results

The findings revealed that cohesion was rated as moderate (mean = 3.32), with higher scores in team affiliation (3.50) compared to psychological cohesion (3.21). Experience-based differences showed that players with less than 5 years and more than 10 years of experience exhibited higher cohesion levels compared to those with 6–10 years. Positional differences favored forwards and guards. Regarding player status, reserve players demonstrated higher cohesion in the psychological and team belonging dimensions, although no significant differences were found in the social dimension.

Conclusion

The study concludes that foreign players have a positive impact on team cohesion, and it was rated as moderate with higher scores in team affiliation compared to psychological cohesion. The researchers recommend careful selection of foreign players to enhance team cohesion and stability. This study contributes to the understanding of foreign players’ role in fostering team dynamics and performance in the Palestinian Basketball League, expanding the literature on the topic. This study is original and valuable, as there has been almost no previous research that has measured and evaluated the impact of foreign players’ participation in the Palestinian basketball league on team cohesion from the perspective of local players.
Reducing the impact of peer victimization on adolescent insomnia: Which is more important, peers or family support?
Authors: Hu Siyi , Wang Yuxuan , Wan Qirong , Chen Zhenhua , Fan Jingyi
Published: February 2025

Background

Adolescent insomnia is a global public health issue, with peer victimization identified as one of the risk factors. However, some adolescents are able to resist the negative impact of peer victimization, and the protective mechanisms underlying this resilience require further clarification. This study aims to evaluate the moderating roles of friendship quality and family functioning on the effects of peer victimization on insomnia.

Methods

Participants (n=506, age=14.49 ± 0.68, 54.5%female) from Hubei, China, completed the Insomnia Severity Index (ISI), Multidimensional Peer Victimization Scale (MPVS), Friendship Quality Questionnaire (FQQ), and Family Adaptation, Partnership, Growth, Affection, and Resolve (APGAR).

Results

The more severe the peer victimization, the higher the level of insomnia among adolescents. Family functioning moderated the relationship between peer victimization and insomnia severity, but no moderating effect of friendship quality was found.

Conclusion

The results suggest that high family functioning can mitigate the impact of peer victimization on insomnia. In the screening and intervention for peer victimization and insomnia among adolescents, the importance of family functioning should be emphasized, while recognizing that friendship quality may not play a significant role.
A survey of public eye-care behavior and myopia education
Authors: Liu Qianwen , Chen Moxin , Yan Tongtong , Jiang Na , Shu Qin , Liang Xiaoyi , Tao Zhuoran , Yang Xuefeng , Nie Wanqin , Guo Yonglin , Li Xiaojing , Zhu Deyi Jasmine , Zeng Changjuan , Li Jin , Li Lin
Published: February 2025

Purpose

To investigate the prevalence of myopia, analyze public eye care behaviors, eye protective practices, and concerns regarding myopia among different age demographics. It also aimed to provide suggestions for improving the dissemination of science popularization about myopia, taking into account different age groups.

Methods

Between May 2022 and July 2022, we gathered data from participants through online questionnaire surveys and subsequently analyzed the collected responses.

Results

The research encompassed a total of 393 individuals, out of which 331 were identified as having myopia. The chi-square test revealed significant correlations between myopia and age (χ2 = 18.7, P = 0.002), comprehensiveness of eye examinations (χ2 = 5.0, P = 0.025), and adherence to the “20-20-20” rule (χ2 = 6.1, P = 0.014). Furthermore, there were notable variations in the frequency and comprehensiveness of eye examinations (χ2 = 14.0, P = 0.016), adherence to the “20-20-20” rule (χ2 = 25.267, P < 0.001), and levels of concern regarding myopia (χ2 = 63.8, P < 0.001) observed across different age groups. Participants aged 17 and below demonstrated a primary interest in acquiring fundamental knowledge about myopia. The 18–25 age group expressed a particular interest in strategies for managing myopia. Conversely, people between the ages of 36–45 are more concerned about whether the many rumors about myopia that have not been medically proven, such as “myopia can be cured,” are true.

Conclusion

As the policies and awareness regarding myopia improve, younger people are adopting better eye-care behaviors in comparison to older populations. Enhancing visual health and reducing the occurrence of myopia requires the improvement of age-appropriate science popularization.
Modern health worries and exposure perceptions of individuals reporting varying levels of sensitivity to electromagnetic fields: results of two successive surveys
Authors: Ledent Maryse , Vatovez Benjamin , Roelandt Philippe , Bordarie Jimmy , Dieudonné Maël , De Waegeneer Els , Kremer Caroline , Boucher Laura , Bouland Catherine , De Clercq Eva Maria
Published: February 2025

Introduction

Individuals who claim to be affected by idiopathic environmental intolerance attributed to electromagnetic fields (EMFs) report symptoms linked to EMF exposure. Uncertainties about the causes of these symptoms often leave them seeking their own care solutions. In our connected societies, they may limit their exposure, leading to a spiral of avoidance that negatively impacts overall health. Our objective is to gain insights into the characteristics of people who report sensitivity to EMFs in an attempt to provide care guidance. This study focuses on modern health worries (MHW), behaviours, and exposure perceptions of people reporting various sensitivity levels to EMFs during the COVID-19 lockdowns, which altered habits and increased telecommunication device use.

Methods

We conducted two surveys during relaxed lockdown periods in Belgium (June/July 2020 and February/March 2021). A total of 97 and 285 participants, respectively, answered a questionnaire on sensitivity to EMFs, MHW, exposure perception, and strategies to limit EMF exposure. We applied nonparametric descriptive and multivariate statistical analyses.

Results

Higher sensitivity to EMFs correlates with greater MHW regarding EMF sources and more strategies to limit EMF exposure. However, these strategies were inconclusive, as many still felt highly exposed to EMFs.

Discussion

Given the high distress, social isolation, and professional difficulties faced by some EMF sensitive individuals, the relevance of exposure avoidance strategies is questionable. People who perceive high sensitivity to EMFs report worries and avoidance behaviors, yet still feel highly exposed. The findings suggest exploring new care avenues.
The Effect of Foliar Calcium Spraying on Changes in the Mechanical Properties of Blueberry (Vaccinium corymbosum L.)
Authors: Komarnicki Piotr , Cieniawska Beata
Published: February 2025

One of the methods used to improve the durability of blueberry fruits is the application of nutrients through foliar feeding with calcium, which can improve the post-harvest mechanical parameters. This study proposed an optimal selection of calcium spray parameters, which enables a rational minimisation of the negative impact of agrochemicals in the environment. The qualitative evaluation of blueberry fruit showed lime spraying induces a significant effect on the increase in fruit size, especially at a pressure of 0.2 MPa and with AIXR nozzles compared to the control group. To assess the mechanical properties, a modern method of identifying the actual loads and maximum surface pressures generated by the picker during harvesting is presented. Compression and fruit rupture tests were also used to determine the pressure values and forces that are considered safe from the perspective of harvest quality. The comparative analysis of destructive compression and detachment tests confirmed that fruit firmness (Fp) was approximately 80% higher than the detachment force (Fpf), with peak pressures more than twice as high, suggesting that handpicking poses minimal risk of mechanical damage. The implementation of optimal spraying techniques combined with the correct assessment of the mechanical properties of fruits is important in agricultural practice, where it is crucial to obtain high-quality blueberries after harvest.
The Combined Application of Inorganic and Organic Materials over Two Years Improves Soil pH, Slightly Increases Soil Organic Carbon, and Enhances Crop Yields in Severely Acidic Red Soil
Authors: He Xiaolin , Wu Yan , Liu Kailou , Ji Jianhua , Wu Chunhong , Li Jiwen , Song Huijie , Hu Dandan , Zhou Chunhuo
Published: February 2025

This study investigates the effects of various treatments on soil pH, SOC, and crop yield in red soil with a pH of 4.25 through a two-year field experiment, using a rapeseed and sesame cropping system. The treatments included the control (CK); lime (CaO) (L); fully fermented pig manure (M); a calcium–magnesium–phosphate fertilizer (P); lime and fully fermented pig manure (LM); lime and the calcium–magnesium–phosphate fertilizer (LP); fully fermented pig manure and the calcium–magnesium–phosphate fertilizer (MP); and lime, fully fermented pig manure, and the calcium–magnesium–phosphate fertilizer (LMP). Then, the changes in yield, soil pH, and SOC were analyzed. The results showed that, among all treatments, the LMP treatment produced the highest yields for both rapeseed (93.62%) and sesame (45.10%); they increased by 93.62% and 45.10% compared with that for CK. Furthermore, these treatments with lime application increased the soil pH. During the rapeseed season, compared with CK, the soil pH values increased by 0.87, 0.75, 0.90, 1.03, 1.24, 1.18, and 1.45 units in the L, M, P, LM, LP, MP, and LMP treatments, respectively. Moreover, they increased by 0.66, 0.34, 0.51, 0.95, 0.82, 0.72, and 1.03 units, respectively, in the sesame season. Similarly, in terms of yield, the highest pH was observed in the LMP treatment for both the rapeseed and sesame seasons. In contrast to soil pH, the effects of these treatments on SOC were less pronounced. Furthermore, the relationship between soil pH and crop yields was significant (R2, p < 0.05). In addition, fitted equations indicated a higher yield response (5.17%) in rapeseed compared with that in sesame (2.32%), while soil pH increased by 0.1 unit. Therefore, the combined application of lime, composted pig manure, and calcium–magnesium–phosphate is an effective strategy to reduce soil acidification and improve crop yield in highly acidified red soils, with the increase in soil pH having a more substantial impact on crop yield than the increase in SOC.
A Precision Medicine Model for Targeted Antibiotic Therapy in Urinary Tract Infections: A Valuable Tool to Reduce Hospitalization Stay and the Time to Switch to Oral Treatment
Authors: Cai Tommaso , Brugnolli Anna , Lanzafame Massimiliano , Dellai Fabiana , Tascini Carlo , Scarparo Claudio , Racanelli Vito , Massidda Orietta , Bonkat Gernot , Gallelli Luca , Johansen Truls E. Bjerklund
Published: February 2025

Background/Objectives: The management of urinary tract infections (UTIs) has become an increasingly challenging medical intervention. This study explores whether adoption of a precision medicine model could improve the management of acute uncomplicated pyelonephritis (uAPN) or complicated UTIs (cUTIs) compared with the standard of care approach, in hospitalized patients. Methods: From January 2022 to March 2024, all patients affected by uAPN or cUTIs and attending our urological institution were randomized to receive the following: antibiotic treatment according to guidelines and recommendations (standard of care group) or antibiotic treatment according to the precision medical model (intervention group). The main outcome measures were the rates of clinical success and the length of hospitalization. The time until switching to oral treatment was regarded as a secondary outcome measure. Results: Eighty-three patients were enrolled in the standard of care group, while seventy-nine patients were enrolled in the intervention group. While the overall clinical success rate was similar in the two groups (75 vs. 72; p = 0.97), a statistically significant difference was observed between the two groups in terms of length of hospitalization (8 days vs. 5 days; p = 0.03) and time to switch to oral treatment (96 h vs. 72 h; p = 0.04). A statistically significant difference was found between the two groups regarding the need to change antimicrobial therapy during hospitalization [12 out of 80 vs. 6 out of 77; p = 0.04]. Conclusions: Adoption of the precision medicine model appears as a valuable means to improve the management of patients with uAPN and cUTIs. By reducing the period of hospitalization and the time to switch to oral treatment, the precision medicine model also improves antimicrobial stewardship in the management of UTIs.
Genome-Wide Identification and Drought-Responsive Functional Analysis of the GST Gene Family in Potato (Solanum tuberosum L.)
Authors: Shi Ningfan , Fan Youfang , Zhang Wei , Zhang Zhijia , Pu Zhuanfang , Li Zhongrun , Hu Lijun , Bi Zhenzhen , Yao Panfeng , Liu Yuhui , Liu Zhen , Bai Jiangping , Sun Chao
Published: February 2025

Glutathione S-transferases (GSTs) play crucial roles in crop stress tolerance through protection against oxidative damage. In this study, we conducted genome-wide identification and expression analysis of the GST gene family in the autotetraploid potato cultivar Cooperative-88 (C88) using bioinformatic approaches. We identified 366 GST genes in the potato genome, which were classified into 10 subfamilies. Chromosomal mapping revealed that StGSTs were distributed across all 12 chromosomes, with 13 tandem duplication events observed in three subfamilies. Analysis of protein sequences identified 10 conserved motifs, with motif 1 potentially representing the GST domain. Analysis of cis-acting elements in the StGSTs promoter regions suggested their involvement in stress response pathways. RNA-seq analysis revealed that most StGSTs responded to both drought stress and DNA demethylation treatments. Quantitative PCR validation of 16 selected StGSTs identified four members that showed strong responses to both treatments, with distinct expression patterns between drought-tolerant (QS9) and drought-sensitive (ATL) varieties. Transient expression assays in tobacco demonstrated that these four StGSTs enhanced drought tolerance and may be regulated through DNA methylation pathways, though the precise mechanisms require further investigation. These findings provide a theoretical foundation for understanding the response and epigenetic regulation of potato GST genes under drought stress.
Integrated Digital-Twin-Based Decision Support System for Relocatable Module Allocation Plan: Case Study of Relocatable Modular School System
Authors: Nguyen Truong Dang Hoang Nhat , Ahn Yonghan , Kim Byeol
Published: February 2025

Relocatable modular buildings (RMBs) offer significant advantages, including flexibility, mobility, and scalability, making them ideal for temporary or rapidly changing scenarios. However, as the scale and quantity of RMB modules increase, their allocation across projects poses complex logistical challenges. Inefficiencies in traditional manual allocation methods, such as suboptimal module selection, increased transportation costs, and project delays, underscore the need for innovative solutions. This study develops a Digital Twin (DT)-based decision support system to optimize the allocation and management of RMB modules. The proposed framework integrates Building Information Modeling (BIM), Internet of Things (IoT), and Geographic Information Systems (GISs), enabling the real-time synchronization of physical assets with their digital counterparts. The DT framework incorporates real-time data acquisition, dynamic module condition assessments, and an algorithm-driven allocation process to streamline resource utilization and logistics planning. The system is validated through a case study of South Korea’s first relocatable modular school system project, demonstrating its capability to optimize module allocation, reduce costs, and enhance lifecycle management. This study advances RMB management by offering a practical, data-driven approach, empowering facility managers to leverage real-time data for preventive maintenance, asset optimization, and sustainable resource utilization.
Assembly of Cellulases from Separate Catalytic Domains and a Cellulose-Binding Module for Understanding Cooperative Crystalline Cellulose Degradation
Authors: Schmitt Katharina K. I. , Hirakawa Hidehiko
Published: February 2025

The biochemical degradation of abundant cellulosic biomass for industrial use and energy production has been extensively researched in recent years. Some elaborate cellulose digestion approaches have been developed based on specialized bacteria, which possess sophisticated mechanisms to efficiently degrade recalcitrant natural carbohydrates. In this study, we assembled catalytic domains from multiple cellulolytic enzymes onto a scaffold along with a cellulose-binding module (CBM), specifically targeting crystalline cellulose. The catalytic domains of endoglucanase and cellobiohydrolase from Acetivibrio thermocellus were linked to a heterotrimeric protein scaffold that assembles in a specific order. The bicatalytic complex failed to show the anticipated synergistic effect in cooperative cellulolysis, presumably because the catalytic domains only serve as weak anchors for each other in binding to the substrate. On the other hand, cellulose digestion was remarkably promoted by incorporating a CBM into a stable complex with a catalytic domain. Interestingly, the reversible association of catalytic domains and excess CBM proved more advantageous than fixed association. This suggests that the dynamic incorporation of CBM units enhances the accessibility of cellulose-degrading catalytic modules to the polysaccharide strand by preventing overly strong binding. This finding could have interdisciplinary applications for enzymes converting polymeric substrates other than cellulose.