bluuebunny/crossref_metadata_2025 huggingface dataset:
Data reduction activities at European XFEL: early results
Authors: Sobolev Egor , Schmidt Philipp , Malka Janusz , Hammer David , Boukhelef Djelloul , Möller Johannes , Ahmed Karim , Bean Richard , Bermúdez Macías Ivette Jazmín , Bielecki Johan , Bösenberg Ulrike , Carinan Cammille , Dall’Antonia Fabio , Esenov Sergey , Fangohr Hans , Ferreira de Lima Danilo Enoque , Ferreira Maia Luís Gonçalo , Firoozi Hadi , Flucke Gero , Gessler Patrick , Giovanetti Gabriele , Koliyadu Jayanath , Madsen Anders , Michelat Thomas , Schuh Michael , Sikorski Marcin , Silenzi Alessandro , Sztuk-Dambietz Jolanta , Turcato Monica , Turkot Oleksii , Wrigley James , Aplin Steve , Hauf Steffen , Wrona Krzysztof , Gelisio Luca
Published: February 2024

The European XFEL is a megahertz repetition-rate facility producing extremely bright and coherent pulses of a few tens of femtoseconds duration. The amount of data generated in the context of user experiments can exceed hundreds of gigabits per second, resulting in tens of petabytes stored every year. These rates and volumes pose significant challenges both for facilities and users thereof. In fact, if unaddressed, extraction and interpretation of scientific content will be hindered, and investment and operational costs will quickly become unsustainable. In this article, we outline challenges and solutions in data reduction.
Passive heating-induced changes in muscle contractile function are not further augmented by prolonged exposure in young males experiencing moderate thermal stress
Authors: Treigyte Viktorija , Chaillou Thomas , Eimantas Nerijus , Venckunas Tomas , Brazaitis Marius
Published: February 2024

Background: We investigated the impact of 1) passive heating (PH) induced by single and intermittent/prolonged hot-water immersion (HWI) and 2) the duration of PH, on muscle contractile function under the unfatigued state, and during the development of muscle fatigue.

Methods: Twelve young males volunteered for this study consisting of two phases: single phase (SP) followed by intermittent/prolonged phase (IPP), with both phases including two conditions (i.e., four trials in total) performed randomly: control passive sitting (CON) and HWI (44–45°C; water up to the waist level). SP-HWI included one continuous 45-min bath (from 15 to 60 min). IPP-HWI included an initial 45-min bath (from 15 to 60 min) followed by eight additional 15-min baths interspaced with 15-min breaks at room temperature between 75 and 300 min. Intramuscular (Tmu; measured in the vastus lateralis muscle) and rectal (Trec) temperatures were determined. Neuromuscular testing (performed in the knee extensors and flexors) was performed at baseline and 60 min later during SP, and at baseline, 60, 90, 150 and 300 min after baseline during IPP. A fatiguing protocol (100 electrical stimulations of the knee extensors) was performed after the last neuromuscular testing of each trial.

Results: HWI increased Tmu and Trec to 38°C–38.5°C (p < 0.05) during both SP and IPP. Under the unfatigued state, HWI did not affect electrically induced torques at 20 Hz (P20) and 100 Hz (P100). However, it induced a shift towards a faster contractile profile during both SP and IPP, as evidenced by a decreased P20/P100 ratio (p < 0.05) and an improved muscle relaxation (i.e., reduced half-relaxation time and increased rate of torque relaxation; p < 0.05). Despite a reduced voluntary activation (i.e., −2.63% ± 4.19% after SP-HWI and −5.73% ± 4.31% after IPP-HWI; condition effect: p < 0.001), HWI did not impair maximal isokinetic and isometric contraction torques. During the fatiguing protocol, fatigue index and the changes in muscle contractile properties were larger after HWI than CON conditions (p < 0.05). Finally, none of these parameters were significantly affected by the heating duration.

Conclusion: PH induces changes in muscle contractile function which are not augmented by prolonged exposure when thermal stress is moderate.
Greater usage and positive mood change for users of a dynamic VR app before and after the COVID-19 pandemic onset
Authors: Housand Jessica , Cornelius Allen , Shackleford Karen E.
Published: February 2024

Americans reported an increase in stress during the novel coronavirus disease 2019 (COVID-19). Virtual reality (VR) apps have been shown to distract users from stressors in the environment, but little is known about the efficacy of specific content features to reduce stress or improve mood for consumer users during a pandemic. The present study investigated secondary archival data to explore how mood and usage behavior changed before and after the onset of COVID-19 for consumer users of a VR app with dynamic, interactive content. Study findings indicate that the COVID-19 pandemic had significant effects on user behavior and mood. Users created more accounts and used app content more often during the pandemic, while reporting increased negative mood states. This suggests that users were motivated to use the content to cope with pandemic stressors. Users also experienced a greater positive mood change after using the content during the pandemic than before, which implies that elements related to the VR app content met users’ psychological needs. Passive content with less interactivity resulted in a greater positive mood state after the COVID-19 onset, likely related to its capacity to reduce stress, facilitate restoration, and improve persistent affective states in stressful environments. This study offers a vital window into how consumer users respond to psychosocial pandemic stressors outside of a controlled environment as well as the prospective for VR app content to serve as a valuable mental health intervention during similar stressful events.
Eight principles of neuro-inclusion; an autistic perspective on innovating inclusive research methods
Authors: Dark Jessica
Published: February 2024

In this article I explain the value of autistic perspectives in research and argue that support for autistic scholars, community leaders and professionals are required as an inclusive research consideration. I propose consolidation, innovation, and evaluation of inclusive research principles, with consideration given to epistemic agency, autistic participation, and actionable research outcomes. I then present “Eight Principles of Neuro-Inclusion,” a reflexive tool that I have designed as a way of encouraging new developments of inclusive research practices. Through flexible application of this approach, it is hoped that innovative new inclusive methods will materialize, in pursuit of epistemic justice, and in support of actionable research outcomes that benefit our autism community.
Hypnotherapy compared to cognitive-behavioral therapy for smoking cessation in a randomized controlled trial
Authors: Batra Anil , Eck Sandra , Riegel Björn , Friedrich Sibylle , Fuhr Kristina , Torchalla Iris , Tönnies Sven
Published: February 2024

Worldwide, more than eight million people die each year as a result of tobacco use. A large proportion of smokers who want to quit are interested in alternative smoking cessation methods, of which hypnotherapy is the most popular. However, the efficacy of hypnotherapy as a tobacco cessation intervention cannot be considered sufficiently proven due to significant methodological limitations in the studies available to date. The aim of the present study was to compare the efficacy of a hypnotherapeutic group program for smoking cessation with that of an established cognitive-behavioral group program in a randomized controlled trial. A total of 360 smokers who were willing to quit were randomly assigned to either hypnotherapy (HT) or cognitive-behavioral therapy (CBT) at two study sites, without regard to treatment preference. They each underwent a 6 weeks smoking cessation course (one 90 min group session per week) and were followed up at regular intervals over a 12 months period. The primary outcome variable was defined as continuous abstinence from smoking according to the Russell standard, verified by a carbon monoxide measurement at three measurement time points. Secondary outcome variables were 7 days point prevalence abstinence during the 12 months follow up and the number of cigarettes the non-quitters smoked per smoking day (smoking intensity). Generalized estimating equations were used to test treatment condition, hypnotic suggestibility, and treatment expectancy as predictors of abstinence. The two interventions did not differ significantly in the proportion of participants who remained continuously abstinent throughout the follow-up period (CBT: 15.6%, HT: 15.0%) and also regarding the 7 days abstinence rates during the 12 months follow-up (CBT: 21.2%, HT: 16.7%). However, when controlling for hypnotic suggestibility, CBT showed significantly higher 7 days abstinence rates. In terms of the continuous abstinence rates, it can be concluded that the efficacy of hypnotherapeutic methods for smoking cessation seem to be comparable to established programs such as CBT.

Clinical trial registration

ClinicalTrials.gov, identifier NCT01129999.
Individual risk factors and prediction of gambling disorder in online sports bettors - the longitudinal RIGAB study
Authors: Wirkus Theresa , Czernecka Robert , Bühringer Gerhard , Kräplin Anja
Published: February 2024

Introduction

While research in online sports betting is dominated by studies using objective player tracking data from providers to identify risky gambling behavior, basicresearch has identified various putative individual risk factors assumed to underlie the development of gambling disorder across all types of gambling. This study aims to examine individual risk factors and their longitudinal clinical relevance in online sports bettors.

Methods

German online sports bettors (N = 607, Mage = 34, 92% male) from a provider based sample took part in an online survey. The study team randomly preselected customers to be invited. N = 325 (53,45%) of the participants also took part in an online follow-up survey one year later. Crosssectional and longitudinal associations of putative risk factors and DSM-5 gambling disorder in online sports bettors were analyzed. These risk factors include alcohol and tobacco use, impulsivity, difficulties in emotion identification, emotion regulation strategies, comorbid mental disorders and stress.

Results

We found more pronounced impulsivity, difficulties in emotion identification, emotion suppression, comorbid mental disorders and stress were cross-sectionally associated with gambling disorder, and longitudinally predicted gambling disorder in online sports bettors (with the exception of emotion suppression). In an overall model only lack of premeditation and perceived helplessness remained significant as predictors for gambling disorder. Online sports bettors with gambling disorder predominantly showed more pronounced risk factors, which were also confirmed longitudinally as relevant for the maintenance of gambling disorder.

Discussion

Risk factors such as impulsivity and stress and appropriate coping mechanisms should consequently be integrated not only into prevention efforts to identify individuals at risk early, but also into intervention efforts to tailor treatment.
Social inequality in the association between life transitions into adulthood and depressed mood: a 27-year longitudinal study
Authors: Jørgensen Magnus , Smith Otto R. F. , Wold Bente , Haug Ellen
Published: February 2024

Background

Few studies have considered the life-course development of depressive symptoms in relation to life transitions in early-adulthood and whether these might affect depressive trajectories differently depending on specific indicators of parental socioeconomic status (SES). In the present work, we explore these questions using the adolescent pathway model as a guiding framework to test socially differential exposure, tracking and vulnerability of the effects of life transitions on depressed mood across different socioeconomic backgrounds.

Methods

Latent growth modeling was used to estimate the associations between indicators of parental SES (parental education and household income) and depressed mood from age 13 to 40 with life transitions (leaving the parental home, leaving the educational system, beginning cohabitation, attaining employment) as pathways between the two. Our analyses were based on a 27-year longitudinal dataset (n = 1242) of a Norwegian cohort with 10 time points in total. To make socioeconomic comparisons, three groups (low, mid, and high) were made for parental education and income respectively.

Results

Depressed mood decreased from age 13 to 40. The low and high parental education groups showed a stable difference in depressed mood during early adolescence, which decreased in young adulthood and then increased slightly in mid-adulthood. The low household income group showed higher depressed mood across young adulthood compared to the medium and higher household income groups. For life transitions, leaving the parental home and beginning cohabitation was associated with an added downturn of the trajectory of depressed mood when adjusting for other transitions. However, adolescents with high parental education showed a relatively stronger decrease in depressed mood when leaving the parental home. Similarly, adolescents with a high household income showed a relatively stronger decrease in depressed mood when leaving the educational system.

Conclusions

Depressed mood decreased over time and developed differently depending on parental education and household income. Life transitions were generally associated with reductions in depressed mood across time, but lower SES youths were not found to be more socially vulnerable these effects.
Multimodal fusion of EMG and vision for human grasp intent inference in prosthetic hand control
Authors: Zandigohar Mehrshad , Han Mo , Sharif Mohammadreza , Günay Sezen Yağmur , Furmanek Mariusz P. , Yarossi Mathew , Bonato Paolo , Onal Cagdas , Padır Taşkın , Erdoğmuş Deniz , Schirner Gunar
Published: February 2024

Objective: For transradial amputees, robotic prosthetic hands promise to regain the capability to perform daily living activities. Current control methods based on physiological signals such as electromyography (EMG) are prone to yielding poor inference outcomes due to motion artifacts, muscle fatigue, and many more. Vision sensors are a major source of information about the environment state and can play a vital role in inferring feasible and intended gestures. However, visual evidence is also susceptible to its own artifacts, most often due to object occlusion, lighting changes, etc. Multimodal evidence fusion using physiological and vision sensor measurements is a natural approach due to the complementary strengths of these modalities.

Methods: In this paper, we present a Bayesian evidence fusion framework for grasp intent inference using eye-view video, eye-gaze, and EMG from the forearm processed by neural network models. We analyze individual and fused performance as a function of time as the hand approaches the object to grasp it. For this purpose, we have also developed novel data processing and augmentation techniques to train neural network components.

Results: Our results indicate that, on average, fusion improves the instantaneous upcoming grasp type classification accuracy while in the reaching phase by 13.66% and 14.8%, relative to EMG (81.64% non-fused) and visual evidence (80.5% non-fused) individually, resulting in an overall fusion accuracy of 95.3%.

Conclusion: Our experimental data analyses demonstrate that EMG and visual evidence show complementary strengths, and as a consequence, fusion of multimodal evidence can outperform each individual evidence modality at any given time.
Are face transplant candidates choosing autonomously? A preliminary method to evaluate autonomous choosing in psychosocial and bioethical assessments
Authors: Farías-Yapur Anneke
Published: February 2024

This report proposes a framework for evaluating the validity of informed consent and autonomy in face transplant candidates, taking into account the risk of depression and non-compliance. Traditional factors like decisional capacity, disclosure, comprehension, voluntariness, and agreement are insufficient for assessing valid informed consent in individuals whose self-worth relies on public perception, potentially leading to self-harm if societal worth is undermined. Reliance on self-esteem, rather than inherent personal value, poses risks of depression, poor treatment adherence, and deferential vulnerability. We suggest a qualitative analysis of self-worth, self-esteem, self-trust, and self-respect to better assess the autonomy of face transplant candidates in their decision-making process.
A Mentee's perspective on Dr. Anthony Monaco: the quiet giant of transplantation
Authors: Nadig Satish N.
Published: February 2024

A mentee's perspective of an academic journey on a path paved by a pioneering transplant surgeon-scientist.
Development and initial validation of the perceived instrumental effects of violence in sport scale
Authors: Parent Sylvie , Radziszewski Stephanie , Gillard Allyson , Bélanger-Gravel Ariane , Gagné Marie-Hélène , St-Pierre Elisabeth , Vertommen Tine , Woodburn Andrea
Published: February 2024

Introduction

A growing body of research is looking into risk factors for interpersonal violence (IV) in sport. This research suggests the existence of several important risk factors, especially organizational and social factors. One of these factors is the beliefs regarding instrumental effects of violence. Coaches may want to drive performance, deter failure, test resilience and commitment, develop toughness, assure interpersonal control, and promote internal competition. In sum, available evidence suggests the risk of IV increases when coaches believe in the effectiveness of strategies involving IV to enhance athlete performance or perceive external approval for these practices.

Methods

The studies presented in this article seeks to develop and validate the Perceived Instrumental Effects of Violence in Sport (PIEVS) Scale in order to measure those beliefs in coaches. In study 1, item generation, expert consultation, cognitive interviews, pilot test and item reduction phases led to 25 items for the PIEVS around six dimensions. In study 2, exploratory factor analysis (EFA) was conducted with 690 coaches in order to determine the PIEVS factorial structure and the convergent and divergent validity of the scale was tested (long and short form).

Results

Our results suggested a one-factor solution for the PIEVS (25 items). This one-factor model provided an excellent fit to the data and a very good internal consistency. The PIEVS and empowering motivational climate were negatively correlated, which supported divergent validity as expected. The PIEVS was positively correlated with the disempowering motivational climate and with sport ethic norms, which supported convergent validity as expected.

Discussion

These findings provide preliminary evidence for the appropriateness of the PIEVS Scale to measure perceived instrumental effects of violence in coaches.
Predictors of stroke literacy among African Americans in the “buckle of the stroke belt”
Authors: Sunmonu N. Abimbola , Malek Angela M. , Jenkins Carolyn , Hyacinth Hyacinth I.
Published: February 2024

Background

Stroke is associated with racial disparities in morbidity and mortality and stroke outcomes. Stroke literacy is a significant predictor of on-time arrival to the emergency room for acute stroke treatment. In this study, we examined sociodemographic and socioeconomic factors that predict key aspects of stroke literacy: knowledge of stroke signs/symptoms and intent to call 911 in the event of a stroke.

Methods

We analyzed archived data from a survey of African American adults over 18 years residing in the “buckle of the stroke belt.” Participants were ranked into 2 categories: low or no and moderate to adequate stroke knowledge. Then we performed univariate and multivariable analyses to determine the independent predictors of (1) knowledge of stroke signs and symptoms and (1) intent to call 911.

Results

Participants aged 18–39 years (OR = 0.46, 95% CI: 0.27– 0.80) were more likely to correctly recognize stroke signs and symptoms compared to those who are 65 years and above. Those age 40–64 years were also more likely to recognize stroke signs and symptoms compared to those who are 65 years and above. On the other hand, those with less than high school (OR = 2.83, 95% CI: 2.03–3.96) or complete high school education (OR = 1.95, 95% CI: 1.28–2.96) were less likely to recognize stroke signs and symptoms. Males were less likely (OR = 0.65, 95% CI: 0.64–0.66) to report that they would call 911 in the event of a stroke. While respondents aged 40–64 years (OR = 1.87, 95% CI: 1.14–3.09) and those with moderate to adequate knowledge of stroke (OR = 1.39, 95% CI: 1.18–1.65) were more likely to call 911 in the event of a stroke. Socioeconomic status was generally associated with stroke literacy.

Conclusion

Among resident of the “buckle of the stroke belt,” we observed that age, sex, and educational level are among the key predictors of knowledge of stroke signs and symptoms and intent to call 911 in the event of a stroke. Stroke literacy and educational programs needs to incorporate these key sociodemographic aspects as a strategy for improving literacy and reduce stroke-related disability and health disparities.
Women's seed entrepreneurship in aquaculture, maize, and poultry value chains in Ghana, Kenya, and Tanzania
Authors: Farnworth Cathy Rozel , Galiè Alessandra , Gumucio Tatiana , Jumba Humphrey , Kramer Berber , Ragasa Catherine
Published: February 2024

Seed systems are essential to bring good genetic material to farmers. Women farmers, however, have benefited less than men farmers from seed systems in low and middle income countries. We identify factors that inhibit and promote women's success in seed businesses through three case studies of women's and men's entrepreneurship across seed-related value chains and country contexts: tilapia seed production in Ghana, marketing and trading of improved maize and sorghum seeds in Kenya, and chicken seed dissemination in Tanzania. Applying a gender lens, we use key informant interviews and focus group discussions to analyze women's and men's motivations to engage in seed businesses, the challenges they confront to start and build their enterprises, and prospects for sustainability and continued success. We use quantitative data to characterize the levels of empowerment of the agripreneurs sampled. For women, the results show that the social normative context of the sector is critical. Time flexibility and profitability are important considerations for women's engagement. Furthermore, across all three country cases, family and external support are frequently key to women's participation and success in seed agripreneurship. The article discusses the importance of government bodies, NGOs, and donors in challenging the normative context around gender resource gaps, as well as provide technical packages and training to develop business acumen. Supporting change of restrictive gender norms in non-threatening ways - such as ICTs - is key.
Benefits of surgical treatment within 48 h of proximal femoral fracture in centenarians: a retrospective cohort study
Authors: Shitahodo Toshiya , Murata Shizumasa , Kitano Yoji , Mera Yoshimasa , Iwahashi Hiroki , Inoue Shingo , Kawamura Kota , Yamada Hiroshi
Published: February 2024

Introduction

Proximal femoral fractures in aging populations represent a significant concern, with an increasing prevalence among individuals aged ≥100 years. The existing research does not provide robust guidance for clinicians managing older patients aged ≥100 years with proximal femoral fractures. We investigated the safety and efficacy of surgical treatment in patients aged ≥100 years with proximal femoral fractures and evaluated the impact of early surgery on their outcomes.

Methods

This retrospective cohort study involved 15 patients aged ≥100 years who underwent surgical treatment of proximal femoral fractures; the control group included 137 patients in their 90s. Data were collected between January 2010 and December 2017. Evaluation items included patient characteristics, surgical details, perioperative complication rates, length of hospital stay, the proportion of patients discharged to the same facility or home, rate of regaining walking ability, and 1-year survival rate.

Results

The patients aged ≥100 years and those in their 90s had comparable outcomes. Thus, age alone does not dictate surgical success. Early surgery (≤48 h) was associated with trends toward improved perioperative complications, ambulatory ability, and return to original living environment.

Discussion

This study underscores the potential benefits of surgical intervention for proximal femoral fractures in patients aged ≥100 years, indicating the relevance of early surgery (≤48 h). Our findings emphasized the importance of timely intervention and evidence-based decision-making for this demographic. Clinicians, policymakers, and patients could benefit from our insights to enhance fracture management strategies, along with future research endeavors to validate and expand our results in larger multicenter cohorts.
Case Report: Hip arthroplasty after fracture-related joint infection caused by extensively drug-resistant Klebsiella pneumoniae
Authors: Fischer Maximilian , Nonnenmacher Lars , Reichert Johannes C. , Bohnert Jürgen A. , Idelevich Evgeny A. , Doğan Eyüp , Becker Karsten , Wassilew Georgi I.
Published: February 2024

This case-report focuses on a 23-year-old soldier suffering from a fracture-related hip joint infection (FRI) due to extensively drug-resistant Klebsiella pneumoniae and S. epidermidis. The patient underwent multiple septic revision surgeries including the removal of remaining shrapnel accompanied by last-resort antimicrobial therapy with cefiderocol and colistin. Additionally, the surgeries included repeated tissue sampling for microbiological and histopathological analysis. An antibiotic-loaded cemented filler containing cefiderocol was used to improve local antimicrobial therapy. The biopsies prior to and during hip replacement surgery confirmed successful microbe eradication. Hip arthroplasty restored hip joint function and significantly improved patient's quality of life. The utilization of a trabecular metal shell and a meta-diaphyseally anchored cementless hip stem ensured secure implant fixation and early patient mobilisation. An adjusted biofilm active oral antimicrobial therapy after arthroplasty intervention was continued to prevent early periprosthetic joint infection. This case emphasizes the difficulties of managing FRI and multidrug-resistant pathogens. It contributes valuable insight into navigating complex orthopedic cases while ensuring successful hip arthroplasty outcomes. In conclusion, early interdisciplinary collaboration, appropriate antimicrobial therapy along with tailored surgical interventions are crucial for managing such complex cases successfully.
The characterization of CellROX™ probes could be a crucial factor in ram sperm quality assessment
Authors: Palacin-Martinez Cristina , Anel-Lopez Luis , Alvarez Mercedes , Neila-Montero Marta , Montes-Garrido Rafael , Soriano-Úbeda Cristina , de Paz Paulino , Anel Luis , Riesco Marta F.
Published: February 2024

Several authors have demonstrated that low levels of reactive oxygen species (ROS) are necessary for the physiological functions of sperm, such as capacitation, hyperactivation, acrosomal reaction and fertilization. However, high levels of ROS are associated with oxidative stress and detrimental effects on fertility. Consequently, deep characterization of ROS presence using different fluorescent probes could be crucial. In this sense, the study of intracellular ROS localization and the relationships between ROS and other conventional parameters could improve the characterization of sperm quality for semen preservation protocols in rams. In this work, a multiparametric study was carried out by analyzing four experimental groups of ram sperm with different initial qualities: fresh semen (from both breeding and nonbreeding seasons), frozen-thawed semen and, a positive control group treated with hydrogen peroxide (300 μM) as a marker of extreme damage. Sperm analyses, including viability, apoptosis, lipid peroxidation, motility and kinetic parameters, were applied to compare several experimental groups with different sperm qualities. After that, the signals from two different ROS probes: CellROX™ Deep Red (CRDR) and Green (CRG), were examined by flow cytometry (percentage of cells that express ROS) and fluorescence microscopy (intracellular ROS location). Comparing conventional parameters, fresh samples from the breeding season showed the highest sperm quality, while the positive control samples showed the worst sperm quality. Concerning the ROS probes, the CRDR levels were higher in fresh samples from the breeding season than in the positive control and cryopreserved samples. Surprisingly, CRG presented its highest level (P < 0.05) in the positive control group treated with peroxide by flow cytometry. CRDR and CRG presented opposite labeling patterns that were corroborated by fluorescence microscopy, which determined that the probes localized in different parts of sperm. CRDR was found in the sperm mitochondrial region, while CRG was observed in the cell nucleus, suggesting that ROS localization is an important factor. Finally, our study indicates that CRDR is correlated with proper viability and sperm motility, and could be associated with high mitochondrial activity, while CRG is associated with sperm damage.
Evaluation of an Interprofessional Blended Learning Course Focusing on Communication within Veterinary Teams
Authors: Heise Sylva Agnete Charlotte , Wissing Sandra , Nerschbach Verena , Preussing Ellen , Tipold Andrea , Kleinsorgen Christin
Published: February 2024

Based on the importance of communication and teamwork in veterinary practice, we explored the impact of a blended learning course designed to enhance interprofessional communication skills among veterinary students and apprentice assistants. The blended learning course design included online modules, synchronous (online) seminars, and simulation training sessions. The asynchronous online elements should complement the varied schedules of different professions and meet the individual needs of participants, especially considering the challenges posed by the COVID-19 pandemic. The course structure, evaluations, and outcomes were documented, showing a positive impact on knowledge gain concerning communication and self-assessment in communication skills. In the pretest, the participants scored 43.18% correct answers to a knowledge test, whereas 71.50% correct answers were given in the posttest. Some participants indicated an improvement in the self-assessment of their skills. For example, before the training only 13.64% answered the question “How prepared do you feel regarding your communication skills for entering the profession?” with “Very good” or “Good”, versus 50.00% in the posttest. There were also only 22.73% of participants who agreed to having sufficient understanding of the roles of other professional groups, while in the posttest, 81.82% agreed. The evaluations highlighted positive feedback on the organization, learning environment, and overall course structure. However, challenges such as limited resources, especially time and financial constraints, influenced the implementation and ongoing development of the course. Subsequent runs of the course could gather more data to further improve the teaching of veterinary interprofessional communication. This ongoing data collection would allow continuous insights into and adjustments to the teaching methods, ensuring maximum benefit for veterinary students and apprentice assistants.
Understanding Circular RNAs in Health, Welfare, and Productive Traits of Cattle, Goats, and Sheep
Authors: Kirgiafini Dimitra , Kyrgiafini Maria-Anna , Gournaris Theocharis , Mamuris Zissis
Published: February 2024

Circular RNAs (circRNAs) are unique noncoding RNA molecules, notable for their covalent closed-loop structures, which play a crucial role in regulating gene expression across a variety of biological processes. This review comprehensively synthesizes the existing knowledge of circRNAs in three key livestock species: Bos taurus (cattle), Ovis aries (sheep), and Capra hircus (goats). It focuses on their functional importance and emerging potential as biomarkers for disease detection, stress response, and overall physiological health. Specifically, it delves into the expression and functionality of circRNAs in these species, paying special attention to traits critical to livestock productivity such as milk production, meat quality, muscle development, wool production, immune responses, etc. We also address the current challenges faced in circRNA research, including the need for standardized methodologies and broader studies. By providing insights into the molecular mechanisms regulated by circRNAs, this review underscores their scientific and economic relevance in the livestock industry. The potential of circRNAs to improve animal health management and the quality of animal-derived products aligns with growing consumer concerns for animal welfare and sustainability. Thus, this paper aims to guide future research directions while supporting the development of innovative strategies in livestock management and breeding.
Design and Evaluation of Flexible Support Based on Space Mirror
Authors: Zhu Zhongyao , Tian Ailing , Liu Bingcai , Wu Yongkun , Dong Suotao
Published: February 2024

The mirror component is one of the most critical components in the space remote sensing payload, and the performance of its support essentially determines the imaging quality of the system. Mirror components need to have high face shape accuracy, high reliability, and high stability. In this paper, taking the square mirror with the size of 550 mm × 450 mm as an example, we chose the Ultra-Low-Expansion Glass (Corning) as the mirror blank material, and through in-depth research on the principle of the three-point backside support and the engineering realization, we designed a three-point backside flexible support structure applied to the space mirror component. The design results were testified by simulation analysis; the results showed that with the mirror’s weight of 13.2 kg, the surface density can reach 48.5 kg/m2. For each gravity acceleration of 1 g, within the temperature range from 16 to 24 °C, carrying a forced displacement of 5 μm, the RMS value of the mirror component can reach 1/55λ (λ = 632.8 nm), which meets the requirement of high face shape accuracy of the mirror component in space. Finally, the mechanical test was carried out on the assembled mirror component, and the intrinsic frequencies of three directions of the mirror component were obtained through the test: 173.8 Hz, 176.4 Hz and 271.5 Hz, respectively. The changes of the mirror and its support structure were all less than 5″ after the 8 g sinusoidal vibration test and the 5.66 g random vibration test, which indicates that the flexible support structure meets the requirements of the high reliability of the space remote sensing loads and the high accuracy of the space mirror component. It shows that the flexible support structure meets the high reliability and high stability requirements of space remote sensing loads. The theoretical data and test results in this research can provide theoretical references for mirror components of the same size and type.
Effect of Surface Renewal on the Drop Size Distribution in Dropwise Condensation within a Hybrid Surface
Authors: Alhashem Abdulwahab , Alrahmani Mosab , Abou-Ziyan Hosny
Published: February 2024

The description of liquid drop growth and drop distribution are two key models in evaluating the thermal performance of dropwise condensation (DWC) heat transfer. The drop size distribution describes the growth process of small drops by direct condensation and large drops by coalescence. The present work investigates the effect of surface renewal and coalescence intensities of DWC within a hybrid surface. Additionally, it examines the validity of the current empirical expression of the drop size distribution that is developed for DWC without considering surface renewal and coalescence intensities. The simulation work illustrates the drop growth process and surface renewal as drops depart and merge with neighboring film regions. The simulation results show that in hybrid DWC, the area fraction occupied by drops (f) lies between 0.28 to 0.296 for the ratio of maximum drop diameter to DWC region width (RD) from 0.125 to 1 and a total temperature drop (∆T) of 2, 4, and 8 ℃. Thus, the drop population is less sensitive to RD, and an average f of 0.288 is generalized. On the other hand, the surface renewal for DWC within the hybrid surface shows improvement for RD > 0.5 with the highest enhancement of 64 to 85% taking place at RD = 1, mainly due to the merging effect. In addition, results for drop size distribution profiles of DWC within the hybrid surface are characterized by a lower population of large drops and a higher population of small drops than full DWC. Additionally, the constant exponent (n) in the literature’s empirical expression is replaced by a polynomial series as a function of drop effective and maximum radii. The impact of surface renewal on coalescence intensity is presented in a relatively steeper slope on the logarithmic scale.
Transfer and Inactivation of Listeria monocytogenes during Pilot-Scale Dicing and Flume Washing of Onions
Authors: Scollon Andrew M. , Wang Haiqiang , Ryser Elliot T.
Published: February 2024

This study assessed the extent of L. monocytogenes transfer from onions to the surface of a commercial dicer, from inoculated onions to uninoculated onions, and the efficacy of various sanitizers during the subsequent flume washing of diced onions. Spanish yellow onions (Allium cepa L.) were dip-inoculated in a 3-strain avirulent L. monocytogenes cocktail (5.9 or 4.2 log CFU/50 g) and air-dried. After dicing one 2.2 kg batch of onions inoculated at ~5.9 log CFU/50 g followed by ten uninoculated batches of 2.2 kg each, L. monocytogenes progressively decreased from 4.6 to 2.6 log CFU/50 g in baches 1 through 10, respectively. After onions inoculated at ~4.0 log CFU/g were diced and flume washed for 2 min in tap water, electrolyzed water containing 55 ppm free chlorine, 80 ppm free chlorine from a commercial sanitizer, or 80 ppm peroxyacetic acid and dewatered on a mechanical shaker table, L. monocytogenes populations decreased 0.4, 0.3, 1.4, and 1.0 log, respectively, with populations of ~1.2 log CFU/mL in water for all three sanitizers. These findings should be useful in future risk assessments and aid in the development of improved industry guidelines to better enhance the safety of diced onions.
OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives
Authors: Sánchez-Puebla Lidia , López-Cuenca Inés , Salobrar-García Elena , Ramírez Ana I. , Fernández-Albarral José A. , Matamoros José A. , Elvira-Hurtado Lorena , Salazar Juan J. , Ramírez José M. , de Hoz Rosa
Published: February 2024

The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD.
Prospective Observational Study of COVID-19 Vaccination in Patients with Thoracic Malignancies: Adverse Events, Breakthrough Infections and Survival Outcomes
Authors: Janzic Urska , Janzic Andrej , Agbarya Abed , Bidovec-Stojkovic Urska , Mohorcic Katja , Caks Marina , Korosec Peter , Rijavec Matija , Skof Erik
Published: February 2024

Due to the devastating COVID-19 pandemic, a preventive tool in the form of vaccination was introduced. Thoracic cancer patients had one of the highest rates of morbidity and mortality due to COVID-19 disease, but the lack of data about the safety and effectiveness of vaccines in this population triggered studies like ours to explore these parameters in a cancer population. Out of 98 patients with thoracic malignancies vaccinated per protocol, 60–75% experienced some adverse events (AE) after their first or second vaccination, most of them were mild and did not interfere with their daily activities. Out of 17 severe AEs reported, all but one were resolved shortly after vaccination. No significant differences were noted considering AE occurrence between different cancer therapies received after the first or second vaccination dose, p = 0.767 and p = 0.441, respectively. There were 37 breakthrough infections either after the first (1), second (13) or third (23) vaccine dose. One patient died as a direct consequence of COVID-19 infection and respiratory failure, and another after disease progression with simultaneous severe infection. Eight patients had moderate disease courses, received antiviral therapies and survived without consequences. Vaccination did not affect the time to disease progression or death from underlying cancer.
Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
Authors: Tavares Catarina , Vieira Tânia , Silva Jorge C. , Borges João P. M. R. , Lança M. Carmo
Published: February 2024

Open-cell foams based on hydroxyapatite (HAp) can mimic the extracellular matrix (ECM) to better replace damaged hard tissues and assist in their regeneration processes. Aerogels of HAp nanowires (NW) with barium titanate (BT) particles were produced and characterized regarding their physical and chemical properties, bioactivity, and in vitro cytotoxicity. Considering the role of piezoelectricity (mainly due to collagen) and surface charges in bone remodeling, all BT particles, of size 280 nm and 2 and 3 µm, contained BaTiO3 in their piezoelectric tetragonal phase. The synthesized nanowires were verified to be AB-type carbonated hydroxyapatite. The aerogels showed high porosity and relatively homogeneous distribution of the BT particles. Barium titanate proved to be non-cytotoxic while all the aerogels produced were cytotoxic for an extract concentration of 1 mg/mL but became non-cytotoxic at concentrations of 0.5 mg/mL and below. It is possible that these results were affected by the higher surface area and quicker dissolution rate of the aerogels. In the bioactivity assays, SEM/EDS, it was not easy to differentiate between the apatite deposition and the surface of the HAp wires. However, a quantitative EDS analysis shows a possible CaP deposition/dissolution cycle taking place.
Towards Precision Ophthalmology: The Role of 3D Printing and Bioprinting in Oculoplastic Surgery, Retinal, Corneal, and Glaucoma Treatment
Authors: Wu Kevin Y. , Tabari Adrian , Mazerolle Éric , Tran Simon D.
Published: February 2024

In the forefront of ophthalmic innovation, biomimetic 3D printing and bioprinting technologies are redefining patient-specific therapeutic strategies. This critical review systematically evaluates their application spectrum, spanning oculoplastic reconstruction, retinal tissue engineering, corneal transplantation, and targeted glaucoma treatments. It highlights the intricacies of these technologies, including the fundamental principles, advanced materials, and bioinks that facilitate the replication of ocular tissue architecture. The synthesis of primary studies from 2014 to 2023 provides a rigorous analysis of their evolution and current clinical implications. This review is unique in its holistic approach, juxtaposing the scientific underpinnings with clinical realities, thereby delineating the advantages over conventional modalities, and identifying translational barriers. It elucidates persistent knowledge deficits and outlines future research directions. It ultimately accentuates the imperative for multidisciplinary collaboration to enhance the clinical integration of these biotechnologies, culminating in a paradigm shift towards individualized ophthalmic care.
Characteristics of Resting-State Electroencephalogram Network in α-Band of Table Tennis Athletes
Authors: Shi Jilong , Nasrallah Fatima A. , Mao Xuechen , Huang Qin , Pan Jun , Li Anmin
Published: February 2024

Background: Table tennis athletes have been extensively studied for their cognitive processing advantages and brain plasticity. However, limited research has focused on the resting-state function of their brains. This study aims to investigate the network characteristics of the resting-state electroencephalogram in table tennis athletes and identify specific brain network biomarkers. Methods: A total of 48 healthy right-handed college students participated in this study, including 24 table tennis athletes and 24 controls with no exercise experience. Electroencephalogram data were collected using a 64-conductive active electrode system during eyes-closed resting conditions. The analysis involved examining the average power spectral density and constructing brain functional networks using the weighted phase-lag index. Network topological characteristics were then calculated. Results: The results revealed that table tennis athletes exhibited significantly higher average power spectral density in the α band compared to the control group. Moreover, athletes not only demonstrated stronger functional connections, but they also exhibited enhanced transmission efficiency in the brain network, particularly at the local level. Additionally, a lateralization effect was observed, with more potent interconnected hubs identified in the left hemisphere of the athletes’ brain. Conclusions: Our findings imply that the α band may be uniquely associated with table tennis athletes and their motor skills. The brain network characteristics of athletes during the resting state are worth further attention to gain a better understanding of adaptability of and changes in their brains during training and competition.