bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilizing Mobile-based Deep Learning Model for Managing Video in Knowledge Management System
Authors: Prabowo Harjanto , Cenggoro Tjeng Wawan , Budiarto Arif , Perbangsa Anzaludin Samsinga , Muljo Hery Harjono , Pardamean Bens
Published: October 2018

Knowledge Management (KM) system is a core feature in facilitating intellectual growth in organization. However, there are numerous difficulties in maintaining a reliable KM system. One of the challenges is to manage knowledge materials in video format. A video file contains complex data that lead to the difficulties in managing them. Without an intelligent system, managing videos for KM requires a laborious effort. In this paper, an intelligent framework for KM system, embedded with deep learning model, is proposed. The use of the deep learning model alleviates the heavy burden of video materials management in KM system. To enhance the agility of the system, mobile-based deep learning model is utilized in the framework.
Development of Physics Mobile Learning Based on Local Wisdom to Improve Vector and Diagram Representation Abilities
Authors: Husna Miftahul , Kuswanto Heru
Published: October 2018

The research aims to 1) develop a feasible physics learning media based on local wisdom (waterwheel); 2) measure the improvement of student’s representation abilities after using of learning media based on local wisdom . The development of media used 4D model ; (a) define, (b) develop, (c) design, and (d) disseminate. The feasibility of the learning media is obtained through expert validation and limited test. The improvement of the students' vector representation and diagram representation abilities was obtained through field test.The participants of field test were 25 students of experimental class and 25 students of control class in SMAN 3 Yogyakarta. The results show that the local wisdom-based learning media is feasible to use based on the expert validation and limited test. The gain score obtained from field test showed that that the learning media can improve the students' vector representation and diagram representation abilities.
Risk assessment for breast cancer and BRCA mutations in women with personal and familial history - doi: 10.4025/actascihealthsci.v35i2.12134
Authors: Clementino Leandro Da Silva , Suzuki Edinei Hideki , Oliveira Karen Brajão
Published: October 2018

Risk estimation tools can be used in clinical practice to promote the counseling, prevention, or increase the surveillance against breast cancer development. The present study aimed to estimate the risk for breast cancer and the odds for BRCA1/2 mutations, and to correlate the values found by the different models. Breast cancer risk was determined by the models of Gail, Claus, BRCAPRO and Boadicea; and for the mutations, Myriad II, Penn II BRCAPRO, and Boadicea models were utilized, in women who have or had the disease (n = 16) and their respective first degree female relatives unaffected (n = 25). Considering non affected women 16% were categorized as high risk for breast cancer development in five years by the Gail model, and all values presented significant correlation among the models (p < 0.05). Among the participants, 12% (5/41) were considered high risk for BRCA mutations. All the models presented significant correlation between the odds of BRCA1/2 mutation risk, except between Myriad II and Boadicea models. Since there is no model that includes all the variables influencing the development of this disease, it is essential to estimate the risk by more than one model before initiating any clinical intervention.
Children with pulmonary atelectasis: clinical outcome and characterization of physical therapy - doi: 10.4025/actascihealthsci.v35i2.12302
Authors: Pozzo Carolina Cotrim Dal , Seibert Paulo Armindo , Fujisawa Dirce Shizuko
Published: October 2018

Pulmonary atelectasis is described as a state of a given region of lung parenchyma collapsed and non-aerated. This study aimed to describe the characteristics and clinical outcome of children with atelectasis, assisted by physical therapy service. This is a case report whose information was collected from records of children hospitalized at the University Hospital of Londrina/HU, in 2009. Seventeen patients with pulmonary atelectasis were treated, aged from 11 days to 9 years old. At initial assessment, 8 (47%) children had no signs of difficulty breathing. The most used techniques were the re-expansion techniques used in all patients (100%), the clearance techniques were performed in 16 (94%) children, and the deflated techniques were used for only one child. The mean number of physical therapy sessions performed for the resolution of atelectasis was 4, ranging from 2 to 9. All 17 cases of atelectasis treated by physical therapy had rapid resolution. Outcome of children treated was satisfactory at short term with low number of physical therapy attendances.
The importance of coating standardization in gastro-resistant capsules produced in magistral pharmacy - doi: 10.4025/actascihealthsci.v35i2.14581
Authors: Franco Suelen Cristina , Silva Flávia Cristina da , Baracat Marcela Maria , Casagrande Rúbia , Rafael Janice Aparecida , Medeiros Daniela Cristina de
Published: October 2018

Gastro-resistant capsules are often used for several purposes, such as protection of unstable drugs in acid medium to the action of gastric fluids or protection of the gastric mucosa to irritants drugs. The aim of this study was to verify the variation of preparations of capsules coating with cellulose acetate phthalate and methacrylic acid copolymer, without drug addition, in 7-10% coating concentrations, prepared manually with four or five immersions in tested coating solution. Results were analyzed considering the formulation’s disintegration test. Within the context of formulations under analysis, it was observed that the capsules coated with cellulose acetate phthalate 10% complied with the pharmacopeia’s disintegration specifications. However, capsules coated with methacrylic acid copolymer did not show accordance with the pharmacopeia’s specifications. The results emphasize the need for the standardization of coating methodology.
FcγRIIb on B Cells and Myeloid Cells Modulates B Cell Activation and Autoantibody Responses via Different but Synergistic Pathways in Lupus-Prone Yaa Mice
Authors: Lin Qingshun , Ohtsuji Mareki , Amano Hirofumi , Tsurui Hiromichi , Tada Norihiro , Sato Ryota , Fukuyama Hidehiro , Nishimura Hiroyuki , Verbeek J. Sjef , Hirose Sachiko
Published: October 2018

C57BL/6 (B6).FcγRIIb−/−.Yaa mice spontaneously develop lethal lupus nephritis. To define the cell type–specific role of FcγRIIb in Yaa-associated lupus, we established B cell– (CD19Cre.Yaa), myeloid cell– (C/EBPαCre.Yaa), and dendritic cell– (DC) (CD11cCre.Yaa) specific FcγRIIb-deficient B6.Yaa mouse strains. CD19Cre.Yaa mice developed milder lupus than B6.FcγRIIb−/−.Yaa mice, indicating that FcγRIIb deficiency on B cells is not sufficient for the development of severe disease. Surprisingly, C/EBPαCre.Yaa mice also showed autoantibody production and mild lupus similar to that in CD19Cre.Yaa mice, whereas CD11cCre.Yaa mice stayed disease free. These observations indicate that FcγRIIb deficiency in B cells and myeloid cells, but not DCs, contributes to the severe disease in B6.FcγRIIb−/−.Yaa mice. Flow cytometric analysis showed that the frequency of peripheral Gr-1− but not Gr-1+ monocyte was increased in B6.FcγRIIb−/−.Yaa and C/EBPαCre.Yaa but not CD19Cre.Yaa mice, suggesting a link between FcγRIIb deficiency on myeloid cells and the high frequency of Gr-1− monocytes. RNA sequencing revealed that compared with Gr-1+ monocytes, Gr-1− monocytes expressed higher levels of the B cell–stimulating cytokines BSF-3, IL-10, and IL-1β, the DC markers CD11c, CD83, and Adamdec1, and the antiapoptotic factors Bcl2 and Bcl6. In conclusion, in Yaa-associated lupus nephritis, FcγRIIb on B cells and myeloid cells modulates B cell activation via different but synergistic pathways. Gr-1− monocytes are the most likely candidate myeloid cells involved.
Seropositivity and Antibody Profiling of Patients Are Dramatically Impacted by the Features of Peptides Used as Immunosorbents: A Lesson from Anti–Citrullinated Protein/Peptide Antibody
Authors: Cornillet Martin , Babos Fruzsina , Magyar Anna , Sebbag Mireille , Verrouil Evelyne , Hudecz Ferenc , Serre Guy , Nogueira Leonor
Published: October 2018

Quantification of Abs toward a single epitope is critical to understanding immunobiological processes. In autoimmunity, the prognostic value of the serological profiles of patients draws much attention, but the detection of Abs toward a single epitope is not well controlled. Particularly, the rheumatoid arthritis (RA)–specific anti–citrullinated protein/peptide Abs (ACPA) are specific to a two-atom change on arginyl residues and are considered a heterogeneous family of Abs. As a model, we studied ACPA to decipher how peptide features used as immunosorbent impact Ab detection. We synthesized 30 peptides encompassing immunodominant epitopes of citrullinated fibrin differing by their length and biotin location and tested them using ELISA with 120 sera from RA and non-RA rheumatic disease controls, generating over 3000 experimental measurements. We showed that minor molecular changes in peptide chemical structure had dramatic consequences. Even when peptides exhibited the same epitope, measured Ab titers were extremely variable, and patients’ seropositivity was discordant in up to 50% of cases. The distance between epitope and biotin was the most critical parameter for efficient Ab detection irrespective of biotin position or peptide length. Finally, we identified a 15-mer peptide bearing a single citrullinated epitope detecting almost all ACPA-positive sera, thus revealing a high degree of homogeneity in RA autoimmune response. This integrative analysis deciphers the dramatic impact of the molecular design of peptide-based technologies for epitope-specific Ab quantification. It provides a model for assay development and highlights that the studies using such technologies can give a wrong perception of biological processes and therefore that medical use of data must be cautious.
Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho
Authors: Xing Yan , Smith Michelle J. , Goetz Christine A. , McElmurry Ron T. , Parker Sarah L. , Min Dullei , Hollander Georg A. , Weinberg Kenneth I. , Tolar Jakub , Stefanski Heather E. , Blazar Bruce R.
Published: October 2018

Age-related thymic involution is characterized by a decrease in thymic epithelial cell (TEC) number and function parallel to a disruption in their spatial organization, resulting in defective thymocyte development and proliferation as well as peripheral T cell dysfunction. Deficiency of Klotho, an antiaging gene and modifier of fibroblast growth factor signaling, causes premature aging. To investigate the role of Klotho in accelerated age-dependent thymic involution, we conducted a comprehensive analysis of thymopoiesis and peripheral T cell homeostasis using Klotho-deficient (Kl/Kl) mice. At 8 wk of age, Kl/Kl mice displayed a severe reduction in the number of thymocytes (10–100-fold reduction), especially CD4 and CD8 double-positive cells, and a reduction of both cortical and medullary TECs. To address a cell-autonomous role for Klotho in TEC biology, we implanted neonatal thymi from Klotho-deficient and -sufficient mice into athymic hosts. Kl/Kl thymus grafts supported thymopoiesis equivalently to Klotho-sufficient thymus transplants, indicating that Klotho is not intrinsically essential for TEC support of thymopoiesis. Moreover, lethally irradiated hosts given Kl/Kl or wild-type bone marrow had normal thymocyte development and comparably reconstituted T cells, indicating that Klotho is not inherently essential for peripheral T cell reconstitution. Because Kl/Kl mice have higher levels of serum phosphorus, calcium, and vitamin D, we evaluated thymus function in Kl/Kl mice fed with a vitamin D–deprived diet. We observed that a vitamin D–deprived diet abrogated thymic involution and T cell lymphopenia in 8-wk-old Kl/Kl mice. Taken together, our data suggest that Klotho deficiency causes thymic involution via systemic effects that include high active vitamin D levels.
Innate Lymphoid Cells Have Decreased HLA-DR Expression but Retain Their Responsiveness to TLR Ligands during Sepsis
Authors: Cruz-Zárate David , Cabrera-Rivera Graciela Libier , Ruiz-Sánchez Bibiana Patricia , Serafín-López Jeanet , Chacón-Salinas Rommel , López-Macías Constantino , Isibasi Armando , Gallegos-Pérez Humberto , León-Gutiérrez Marco Antonio , Ferat-Osorio Eduardo , Arriaga-Pizano Lourdes , Estrada-García Iris , Wong-Baeza Isabel
Published: October 2018

Sepsis, one of the leading causes of death in intensive care units, is caused by a dysregulated host response to infection that leads to life-threatening organ dysfunction. The proinflammatory and anti-inflammatory responses activated by the infecting microorganism become systemic, and the sustained anti-inflammatory response induces a state of immunosuppression that is characterized by decreased expression of HLA-DR on monocytes, T cell apoptosis, and reduced production of TNF-α by monocytes and macrophages in response to TLR ligands. Innate lymphoid cells (ILCs) are lymphocytes that lack Ag-specific receptors and lineage-specific markers; they express HLA-DR and are activated by cytokines and by direct recognition of microbial molecules. In this study, we evaluated if ILCs are affected by the anti-inflammatory response during sepsis. We found that the number of peripheral blood ILCs was decreased in septic patients compared with healthy volunteers; this decrease was caused by a reduction in ILC1 and ILC3 and is associated with apoptosis, because ILCs from septic patients expressed active caspase 3. ILCs from septic patients had decreased HLA-DR expression but increased expression of the activating receptors NKp46 and NKp44; they also showed a sustained expression of CD127 (IL-7R α-chain) and retained their capacity to produce TNF-α in response to TLR ligands. These results indicate that during sepsis, ILCs have decreased HLA-DR expression and die via apoptosis, similar to monocytes and T cells, respectively. However, other effector functions of ILCs (activation through NKp46 and NKp44, TNF-α production) may remain unaffected by the immunosuppressive environment prevailing in septic patients.
Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell Activation
Authors: Akkaya Billur , Roesler Alexander S. , Miozzo Pietro , Theall Brandon P. , Al Souz Jafar , Smelkinson Margery G. , Kabat Juraj , Traba Javier , Sack Michael N. , Brzostowski Joseph A. , Pena Mirna , Dorward David W. , Pierce Susan K. , Akkaya Munir
Published: October 2018

Activation of CD4+ T cells to proliferate drives cells toward aerobic glycolysis for energy production while using mitochondria primarily for macromolecular synthesis. In addition, the mitochondria of activated T cells increase production of reactive oxygen species, providing an important second messenger for intracellular signaling pathways. To better understand the critical changes in mitochondria that accompany prolonged T cell activation, we carried out an extensive analysis of mitochondrial remodeling using a combination of conventional strategies and a novel high-resolution imaging method. We show that for 4 d following activation, mouse CD4+ T cells sustained their commitment to glycolysis facilitated by increased glucose uptake through increased expression of GLUT transporters. Despite their limited contribution to energy production, mitochondria were active and showed increased reactive oxygen species production. Moreover, prolonged activation of CD4+ T cells led to increases in mitochondrial content and volume, in the number of mitochondria per cell and in mitochondrial biogenesis. Thus, during prolonged activation, CD4+ T cells continue to obtain energy predominantly from glycolysis but also undergo extensive mitochondrial remodeling, resulting in increased mitochondrial activity.
Ou-Testamentiese perspektiewe ten dienste van die besinning oor die vrou in die kerklike amp
Authors: Loader J.A.
Published: October 2018

No abtstract available.
Die elan1 in die lewe en werk van Edmund Husserl
Authors: De Beer G.J.
Published: October 2018

No abstract available.
Die eise van 'n funksionele kultuur
Authors: Lamprecht J.
Published: October 2018

No abstract available.
Evidence for Neuroinflammation after Myocardial Infarction in a Mouse Model
Authors: Gouweleeuw Leonie , Pol Christine , Simonides Warner S. , de Kleijn Dominique PV , Schoemaker Regien G.
Published: October 2018

Background:

The cardiovascular system and central nervous system are known to influence each other. Accordingly, neurological changes may occur after myocardial infarction (MI), which may be mediated by neuroinflammation. We investigated tumor necrosis factor alpha (TNF-α) and microglia activation in post-MI neuroinflammation.

Materials and Methods:

MI or sham surgery was induced in 28 male mice. Two weeks later, we performed echocardiography and dissected the brains for the western blot on TNF-α and its receptors (n = 10) or immunohistochemical stainings for microglia, doublecortin X (DCX), and TNF-α (n = 18). Plasma was collected for the measurement of circulatory cytokines.

Results:

The MI mice had an average infarct size of 38% of the left ventricle, heart failure was confirmed by decreased fractional shortening and increased lung weight. Plasma cytokine levels were unaltered. In brains of MI mice, there was a higher expression of TNF-α precursor protein, with trends for higher TNF-R1 and lower TNF-R2 expression. Furthermore, MI mice had more activated microglia in the inner blade of the dentate gyrus of the hippocampus. The amount of neurogenesis measured by DCX staining was unaltered.

Conclusions:

Our mouse model of MI showed signs of persistent neuroinflammation as indicated by raised levels of TNF-α precursor protein and an increased number of activated microglia in the hippocampus. The extent to which these neuroinflammatory hallmarks influence central nervous system functioning remain to be determined.
Symptomatic High-Risk Congenital Coronary Anomaly
Authors: Oman Zachary , Ampadu James , Khalid Nauman , Abraham Leni , Helmy Tarek , Nasir Ammar
Published: October 2018

Anomalous coronary arteries are rare entities with certain categories being potentially malignant with the risk of sudden cardiac death. We present two cases of the highest risk variant consisting of an anomalous left coronary artery arising from the right sinus of Valsalva traversing between the aorta and pulmonary artery leading to recurrent syncope and chest pain in middle-aged patients.
Takotsubo Syndrome and Heart Transplantation
Authors: De Giorgi Alfredo , Fabbian Fabio , Guarino Matteo , Spampinato Michele Domenico , Boari Benedetta , Cappadona Rosaria , Zucchi Beatrice , De Giorgio Roberto , Manfredini Roberto
Published: October 2018

Takotsubo syndrome (TTS) is a clinical syndrome characterized by transient left ventricular dysfunction, ischemic electrocardiographic changes, and minimal release of myocardial enzymes without obstructive coronary artery disease. This syndrome that mimics an acute myocardial infarction is prevalent among female patients and is regarded as a benign medical condition. The precise pathophysiological mechanism of TTS is complex and not completely understood, but specific emotional or physical events precipitate this syndrome that represents a typical condition characterized by interactions between cardiovascular and neuropsychological diseases. In addition, many different neurological disorders, such as stroke, subarachnoid bleeding, head injury, epilepsy, and bacterial meningitis, have directly or indirectly related to TTS; unfortunately, these acute neurological diseases represented the cause of death in patients nominated for organ donation and in particular for the heart donor. This article reviews the relationship between TTS and solid organ transplantation; in particular, this article highlights the possible mechanisms underlying the induction of TTS in pre- and post-transplantation phases and in heart-transplant patients.
Primary free fibula reconstruction in life-threatening haemorrhage from high flow arteriovenous malformation of mandible
Authors: Ravula Parvathi , Rangachari Srikanth , Susarla Rammurti , Sambari Laxman , Jammula Srinivas Saraswathi
Published: October 2018

Background: High flow arteriovenous malformation (AVM) of the mandible is rare, but it can present as a life-threatening emergency with severe intraoral bleeding for the first time. The gold standard of treatment for an AVM of the mandible is selective embolisation combined with resection and subsequent reconstructions. With the advent of advanced multidisciplinary techniques aimed at definitive therapy, surgical resection and primary reconstruction can provide an ideal anatomical and functional cure. There are no previous reports on primary resection and reconstruction for life-threatening haemorrhage from high flow AVM of the mandible. Aim: We discuss our approach aimed at definitive therapy in life-threatening intraoral bleeding from large high flow AVM of the mandible. Subjects and Methods: Four patients were managed for life-threatening intraoral bleeding during 2015–2017. Compression was applied over the bleeding point before the airway could be secured by endotracheal tube. Under general anaesthesia, the external carotid artery (ECA) was temporarily occluded using an umbilical tape loop ligature to control the bleeding. Emergency selective embolisation was done, followed by curative resection and primary mandible reconstruction using free fibula flap. Outcome assessed. Results: Temporary occlusion of the ECA successfully controlled the bleeding immediately and facilitated selective embolisation and definitive therapy. All the four cases were successfully reconstructed with a good outcome. There was no recurrence during the follow-up period. Conclusion: In life-threatening intraoral bleeding from large high flow AVM of the mandible, emergency selective embolisation followed by curative resection and primary reconstruction is safe in achieving an ideal cure.
Defining giant mandibular ameloblastomas – Is a separate clinical sub-entity warranted?
Authors: Kanoi Aditya V. , Banerjee Tibar , Sundaramurthy Narayanamurthy , Sarkar Arindam , Kanoi Pooja , Saha Sushovan
Published: October 2018

Context: The term giant mandibular ameloblastoma (GMAs) while being in popular usage in the medical literature remains largely equivocal. Although a few authors have in the past attempted to ascribe definite criteria to this entity, these are by and large arbitrary and without any benefit in decision-making or contributing to its management. Aims: The aim of this study is to propose a set of objective criteria for GMAs that can be clinically correlated and thereby aid in the management of this entity. Patients and Methods: Of a total of 16 patients with ameloblastoma of the mandible presenting at our institute from August 2012 to September 2016, 11 patients were identified as having GMAs as per the criteria proposed. Results: The defects in the mandible following segmental resection ranged from 7 to 11.5 cm in length (mean: 9.3 cm). No clinical or radiological evidence of tumour recurrence was found during a mean follow-up period of 10.7 months (range: 2–28 months). Conclusions: Defining GMA based on objective inclusion and exclusion criteria allows segregation of these lesions, thereby helping to remove ambiguity, simplify decision-making and facilitate communication among treating reconstructive surgeons. Inclusion criteria include: (i) The segmental bone defect following resection with a minimum 1 cm margin of healthy bone should exceed 6 cm (ii) The segmental bone defect should involve the central mandibular segment.
Adipofascial perforator flaps: Its role in reconstruction of soft-tissue defects of lower leg and ankle
Authors: Nanda Deepak , Sahu Shamendra Anand , Karki Durga , Kumar Sanjay , Mandal Amrita
Published: October 2018

Background: Despite advances in surgical skills, adipofascial flaps are still less preferred option for coverage of leg defect. We evaluate the use of perforator-based adipofascial flap in small-to-medium-sized soft-tissue defects in the lower limb. Patients and Methods: After localisation of perforators along the major axial vessels in the lower limb using handheld Doppler, adipofascial flap based on the nearest best perforator of anterior tibial artery, posterior tibial artery and peroneal artery was raised to cover soft-tissue defect in 21 patients. The flap was transposed over the defect and covered by split-skin graft. Donor site was primarily closed. Flap complications, functional and aesthetic outcomes are noted in follow-up. Results: There was partial loss of flap in five patients. After debridement and dressings, split-skin grafting was done for four patients and one patient was managed with local flap. Scar over the flap was stable with no reports of recurrent ulceration or breakdown of wound in 6-month follow-up. Four of five patients reported adequate healing of the fractured bone. Average visual analogue score was 8.24/10 for appearance of donor site as evaluated by the patient. Conclusions: Perforator-based adipofascial flap is a good alternative for coverage of small-to-medium-sized soft-tissue defect of the leg, particularly over the malleolus and lower part of the leg. Use of adipofascial tissue and primary closure of the donor site causes minimal donor-site morbidity. Adipofascial perforator flap provides aesthetically superior recipient-site scar with satisfactory functional outcome.
An important superficial vein of the radial aspect of the forearm: An anatomical study
Authors: Vathulya Madhubari , Ansari Mohd Salahuddin
Published: October 2018

Introduction: The superficial veins of upper limbs are seldom talked about. They are always avoided quoting them to be variable in anatomy. Other than the cephalic and basilic veins, no other superficial vein has caught the eyes of anatomists and other health professionals significantly. This article tries to explain the importance of a superficial vein that closely traces the radial vessels and explains its possible use in microvascular reconstruction. Materials and Methods: The forelimbs of 26 upper limbs of fresh frozen cadavers were dissected out. The anatomy of the superficial vein that follows the radial vessels was traced out from wrist to cubital fossa. Their relation to the deep venous system and cephalic veins was followed and documented. Results: All the 26 upper limbs showed the existence of the superficial vein that follows the radial vessels. The study also revealed the existence of venous perforators which are in turn the communication channels between the deep and superficial venous systems. Conclusion: The existence of the surface vein can logically hold an explanation for flap failure or success when one vein anastomosis is contemplated for radial forearm-free tissue transfers.
Outcomes following pharyngeal reconstruction in total laryngectomy – Institutional experience and review of literature
Authors: Balasubramanian Deepak , Subramaniam Narayana , Rathod Priyank , Murthy Samskruthi , Sharma Mohit , Mathew Jimmy , Thankappan Krishnakumar , Iyer Subramania
Published: October 2018

Background: Pharyngeal reconstruction is a challenging aspect of reconstruction after resections for head-and-neck cancer. The goals of reconstruction are to restore the continuity of the pharyngeal passage to enable oral alimentation and rehabilitation of speech wherever possible. This study was performed to determine the outcomes following pharyngeal reconstruction in total laryngectomy (TL) using different reconstructive options and to determine the predictors of pharyngocutaneous fistula (PCF) and swallowing dysfunction. Materials and Methods: Retrospective analysis of patient data between 2003 and 2010 of patients undergoing TL with partial or total pharyngectomy. Demographic and treatment details were collected and analysed. Univariate analysis was performed to determine predictors of PCF and swallowing dysfunction. Results: Fifty-seven patients underwent pharyngeal reconstruction following TL, 31 of whom had received prior treatment. Following tumour resection, 31 patients had circumferential defects and 26 patients had partial pharyngeal defects. The flaps used include pectoralis major myocutaneous flap (n = 29), anterolateral thigh flap (n = 8), gastric pull-up (n = 13) and free jejunal flap (n = 7). PCF was seen in 20 patients, of which 15 (75%) were managed conservatively and 5 required another surgery. At last follow-up, 99 patients (68%) were on full oral alimentation. Tracheo-oesophageal puncture and prosthesis insertion was done in 20 patients, of whom 17 (85%) developed satisfactory speech. Partial pharyngeal defects were associated with a higher risk of PCF on univariate analysis (P = 0.006) but were not significant on multivariate analysis. Post-operative swallowing dysfunction was significantly higher with hypopharyngeal involvement by tumour (P = 0.003). Conclusion: Pharyngeal reconstruction in TL is feasible with good results. Majority of the patients swallow and regain acceptable swallowing function within 3 months.
Bar simplicial modules and secondary cyclic (co)homology
Authors: Laubacher Jacob , Staic Mihai D. , Stancu Alin
Published: October 2018

In this paper we study the simplicial structure of the complex

C^{\bullet}((A,B,\varepsilon); M)

, associated to the secondary Hochschild cohomology. The main ingredient is the simplicial object

\mathcal{B}(A,B,\varepsilon)

, which plays a role equivalent to that of the bar resolution associated to an algebra. We also introduce the secondary cyclic (co)homology and establish some of its properties (Theorems 4.11 and 5.11).
The prime spectrum of the algebra $\mathbb K_q[X,Y]\rtimes U_q(\mathfrak {sl}_2)$ and a classification of simple weight modules
Authors: Bavula Vladimir V. , Lu Tao
Published: October 2018

For the algebra

A

in the title, it is shown that its centre is generated by an explicit quartic element. Explicit descriptions are given of the prime, primitive and maximal spectra of the algebra

A

. A classification of simple weight

A

-modules is obtained. The classification is based on a classification of (all) simple modules of the centralizer

C_A(K)

of the quantum Cartan element

K

which is given in the paper. Explicit generators and defining relations are found for the algebra

C_A(K)

(it is generated by 5 elements subject to the defining relations two of which are quadratic and one is cubic).
Матрица монодромии для уравнения почти-Матье с малой константой связи
Authors: Fedotov Aleksandr Aleksandrovich
Published: October 2018

Для оператора почти-Матье с малой константой связи мы вычисляем асимптотики матрицы монодромии и асимптотически описываем серию лакун в спектре.
Мощность множества $\Lambda$ определяет геометрию пространств $\mathsf{B}_{\ell_\infty(\Lambda)}$ и $\mathsf{B}_{\ell_\infty(\Lambda)^*}$
Authors: Garcia-Pacheco Francisco Javier
Published: October 2018

Изучена геометрия единичного шара в пространстве $\ell_\infty(\Lambda)$ и в сопряженном пространстве и среди прочего доказано, что множество $\Lambda$ счетно тогда и только тогда, когда $1$ - выступающая точка шара $\mathsf{B}_{\ell_\infty(\Lambda)}$. С другой стороны, доказано, что множество $\Lambda$ конечно тогда и только тогда, когда функционалы $\delta_\lambda$ - единственные функционалы, принимающие значение $1$ на каком-либо каноническом элементе и обращающиеся в нуль на остальных
канонических элементах. Показано также, что сужения функционалов вычисления на некоторое двумерное подпространство не обязаны быть крайними точками пространства, сопряженного к этому двумерному подпространству. Наконец, доказано, что если $\Lambda$
несчетно, то грань шара $\mathsf{B}_{\ell_\infty(\Lambda)^*}$, состоящая из функционалов единичной нормы, норма которых
достигается на постоянной функции $1$, имеет пустую внутренность относительно единичной сферы $\mathsf{S}_{\ell_\infty(\Lambda)^*}$.
Дискриминантные расслоения окружностей над локальными моделями графов Штребеля и кривых Бутру
Authors: Bertola Marco , Korotkin Dmitrii Aleksandrovich
Published: October 2018

Изучаются специальные "дискриминантные" расслоения окружностей над двумя элементарными пространствами $\mathcal Q_0^{\mathbb{R}}(-7)$ и $\mathcal Q^{\mathbb{R}}_0([-3]^2)$ модулей мероморфных квадратичных дифференциалов с вещественными периодами. Пространство $\mathcal Q_0^{\mathbb{R}}(-7)$ - это пространство модулей мероморфных квадратичных дифференциалов на сфере Римана с одним полюсом седьмого порядка и вещественными периодами. Оно возникает естественным образом при исследовании окрестности цикла Виттена $W_5$ в комбинаторной модели, основанной на квадратичных дифференциалах Дженкинса-Штребеля пространств модулей $\mathcal M_{g,n}$. Пространство $\mathcal Q^{\mathbb{R}}_0([-3]^2)$ - это пространство модулей мероморфных квадратичных дифференциалов на сфере Римана с двумя полюсами порядка не выше третьего и вещественными периодами. Оно возникает при описании окрестности границы Концевича $W_{1,1}$ комбинаторной модели. Применение формализма тау-функций Бергмана к комбинаторной модели для аналитического вычисления циклов, пуанкаре-дуальных определенным комбинациям тавтологических классов, требует изучения специальных сечений расслоений окружностей над $\mathcal Q_0^{\mathbb{R}}(-7)$ и $\mathcal Q^{\mathbb{R}}_0([-3]^2)$; в случае пространства $\mathcal Q_0^{\mathbb{R}}(-7)$ сечение этого расслоения окружностей задается аргументом модулярного дискриминанта. Подробно изучаются пространства $\mathcal Q_0^{\mathbb{R}}(-7)$ и $\mathcal Q^{\mathbb{R}}_0([-3]^2)$, также называемые пространствами кривых Бутру, и соответствующие расслоения окружностей.
О модели Сачдева-Йе-Китаева в реальном времени
Authors: Aref'eva Irina Yaroslavna , Volovich Igor Vasil'evich
Published: October 2018

Обсуждается непертурбативная формулировка модели Сачдева-Йе-Китаева. Статистическая сумма модели может быть представлена как функциональный интеграл по переменным Грассмана в евклидовом времени, который хорошо определен, но интеграл расходится после преобразования к фермионным билокальным полям. Отмечено, что производящий функционал модели Сачдева-Йе-Китаева в реальном времени хорошо определен даже после преобразования к билокальным полям и его можно использовать для непертурбативных исследований модели. Модель изучается в размерности ноль, построено ее разложение при больших $N$ и исследуются фазовые переходы.
Асимптотика волновых функций стационарного уравнения Шредингера в камере Вейля
Authors: Dobrokhotov Sergey Yur'evich , Minenkov Dmitrii Sergeevich , Shlosman Semen Bensionovich
Published: October 2018

Изучаются стационарные решения уравнения Шредингера с монотонным потенциалом $U$ в некотором многогранном угле (камере Вейля) с граничным условием Дирихле. Потенциал имеет вид $U(\mathbf x)=\sum_{j=1}^nV(x_j)$, ${\mathbf x=(x_1,…,x_n)\in\mathbb R^n}$, c монотонно возрастающей функцией $V(y)$. Построены квазиклассическиеасимптотики собственных значений и собственных функций в виде определителя Слэтера, составленного из функций Эйри с нелинейно зависящими от $x_j$ аргументами. Предложен основанный на канонических преобразованиях способ реализации канонического оператора Маслова в виде функции Эйри.
Ненормированные томограммы и квазираспределения квантовых состояний
Authors: Man'ko Vladimir Ivanovich , Markovich Lyubov' Anatol'evna
Published: October 2018

Рассматриваются томограммы и квазираспределения, такие как функции Вигнера, $P$-функция Глаубера-Сударшана и $Q$-функция Хусими, нарушающие стандартное условие нормировки для функции распределения вероятности. В этом случае преобразование Радона функции Вигнера может быть неприменимо для определения томограммы. Также выражения для функции Вигнера и томограммы через волновую функцию и матрицу плотности перестают быть обратимыми. Получены условия, налагаемые на функцию Вигнера и томограмму, которые позволяют обойти эти ограничения. Изучены три различных квантовых состояния: плоская волна де Бройля, затвор Мошинского и движение заряженной частицы в равномерном и постоянном электрическом поле. Их томограммы и функции квазираспределения, выражающиеся в терминах дельта-функции Дирака, функции Эйри и интегралов Френеля, нарушают условия нормировки.
Перенормируемость и унитарность модели Энглера-Браута-Хиггса-Киббла
Authors: Slavnov Andrei Alekseevich
Published: October 2018

Показано, что модель Энглера-Браута-Хиггса-Киббла является перенормируемой и унитарной.
Financially Focused Self-Concept is Associated with Etiological and Maintenance Factors of Gambling Disorder Among Non-Problem Gamblers
Authors: Tabri Nassim , Wohl Michael J A , Wood Richard T , Philander Kahlil
Published: October 2018

We examined associations between financially focused self-concept and known etiological and maintenance factors of problematic gambling in a sample of community-based gamblers (N = 412). Although most participants (95.6%) did not report gambling problems, those high in financial focus were more likely to be impulsive, to be dissatisfied with their financial situation, to believe that they have a poor ability to cope with adversity in their life, and to have erroneous beliefs about gambling. The magnitude of these associations was moderate. The etiological risk and maintenance factors explained unique variance in financially focused self-concept. Thus, the results provide novel insight into the characteristics of financially focused gamblers.RésuméNous avons examiné les associations entre le concept de soi d’un point de vue financier et les facteurs étiologiques et de maintien connus du jeu problématique dans un échantillon de joueurs communautaires (N = 412). Bien que la plupart des participants (95,6%) n’aient pas déclaré avoir de problèmes de jeu, ceux qui accordaient beaucoup d’importance à l’aspect financier étaient plus susceptibles d’être impulsifs, insatisfaits de leur situation financière, croyaient avoir une faible capacité à affronter l’adversité dans leur vie et avaient des croyances erronées sur les jeux d’argent. L’importance de ces associations était modérée. Les facteurs étiologiques de risque et de maintien ont expliqué la seule variance du concept de soi d’un point de vue financier. Ainsi, les résultats fournissent un nouvel aperçu des caractéristiques des joueurs ayant une image axée sur les finances.
The prevalence of problem gambling and gambling-related behaviours among older adults in Ontario
Authors: Van der Maas Mark , Mann Robert E , Turner Nigel E , Matheson Flora I , Hamilton Hayley A , McCready John
Published: October 2018

As the proportion of Canadians over the age of 55 continues to rise, it accordingly becomes increasingly important to understand the implications that their leisure activities have for their physical and mental health. Gambling is a form of leisure that presents relatively high risk for its participants and remains a popular leisure pursuit among older adults. The current study uses a representative survey of 2,187 adults over the age of 55 in Ontario to explore problem gambling and gambling-related behaviours among older adults. The findings show that 1.8% of the population over the age 55 were classified as experiencing moderate-to-severe problem gambling. While differences across sex were observed in types of gambling, attitudes towards gambling, and frequency of gambling, no significance difference in problem gambling was observed. Findings are discussed in relation to previous findings on older adults’ gambling patterns and their implications for mental, physical and financial well-being.RésuméAvec la constante augmentation de la proportion de Canadiens âgés de plus de 55 ans, il devient de plus en plus important de comprendre les répercussions qu’ont leurs activités de loisir sur leur santé physique et mentale. Le jeu est une forme de loisir qui présente un risque relativement élevé chez les personnes qui s’y adonnent et demeure un loisir populaire chez les personnes plus âgées. L’étude en question a utilisé un sondage représentatif auprès de 2187 adultes âgés de plus de 55 ans en Ontario pour explorer le jeu problématique et les comportements liés au jeu chez les personnes plus âgées. Les résultats montrent que 1,8 % de la population âgée de plus de 55 ans a été classée comme ayant un problème de jeu, de modéré à grave. Bien que des différences entre les sexes aient été observées dans les types de jeu, les attitudes à l’égard du jeu et la fréquence, aucune différence significative n’a été observée dans le jeu problématique. Les résultats sont examinés en lien avec des conclusions antérieures sur les habitudes de jeu des personnes plus âgées et leurs répercussions sur le bien-être mental, physique et financier.
Cheating and stealing to finance gambling: analysis of screening data from a problem gambling self-help program
Authors: Lind Kalle , Kääriäinen Juha
Published: October 2018

Previous studies have suggested strongly that early engagement in gambling anticipates severe gambling problems. Problem gambling and gambling addiction are linked to financial difficulties, depression and weakened life control. One social consequence of excessive gambling is property crime. In this study, we analyze screening data (N = 1573) from a problem gambling self-help program to locate predictors of such criminal behaviour. We applied logistic regression to determine the relationship between problem gambling and both reported cheating and stealing. Our objective was to create an empirically-based model of the different risk factors related to such criminogenic gambling. Our models suggest that self-reported gambling-related cheating and stealing is related to young age, low education, low income, a high rate of depression, a long history of problem gambling, and negative subjective perception of one’s financial situation.RésuméDes études antérieures ont confirmé qu’une participation précoce à des jeux d’argent prédit de graves problèmes de jeu. Le jeu compulsif et la dépendance au jeu sont liés aux difficultés financières, à la dépression et à un faible contrôle sur la vie. Une conséquence sociale du jeu excessif est la criminalité contre les biens. Dans cette étude, nous analysons les données de dépistage (N = 1573) d’un programme d’auto-assistance sur le jeu problématique pour trouver des prédicateurs d’un tel comportement criminel. Nous avons appliqué la régression logistique pour déterminer la relation entre le jeu problématique et la tricherie et le vol rapportés. Notre objectif était de créer un modèle empirique des différents facteurs de risque liés à ces jeux criminogènes. Nos modèles suggèrent que la tricherie et le vol autodéclarés attribuables au jeu sont liés au jeune âge, à un faible niveau de scolarité, à un faible revenu, à un taux élevé de dépression, à une longue histoire de jeu compulsif et à une perception subjective négative de sa situation financière.
Menkiti, Gyekye and beyond: towards a decolonization of African political philosophy
Authors: Eze Michael Onyebuchi
Published: October 2018

No Abstract
Withdrawn: Book Review: Exploring the Question of Reincarnation in African Philosophy within an Intracultural and Intercultural Context
Authors: Agada Ada
Published: October 2018

There was a mix-up during the publication process. The Book Review file that was supposed to be part of this Vol 7 No 2 was mistakenly switched for the one that was published in Vol 7 No 1. We are withdrawing this Book Review piece because it has already been published in Vol 7 No 1.Book Title:  Reincarnation: A Question in the African Philosophy of MindBook Author: Hasskei M. MajeedUNISA Press. Pages: 275. Year of Publication: 2017
Radical versus moderate communitarianism: Gyekye’s and Matolino’s misinterpretations of Menkiti
Authors: Ikuenobe Polycarp
Published: October 2018

This essay provides an exposition and a plausible interpretation of Ifeanyi Menkiti’s conception of personhood vis-a-vis this community. I do this, partly, to rebut some specific criticisms by Kwame Gyekye and Bernard Matolino. They construe Menkiti’s account, primarily, as a metaphysical thesis about the community that provides the essential ontological basis for the nature of personhood. They argue that this view of communitarianism is radical or extreme because the community diminishes individuality and prioritizes community’s interests over individuals’ interests, freedom, and rights. I argue that Gyekye’s and Matolino’s interpretations of Menkiti’s view are mistaken, and that Menkiti’s account of the connection between the community and personhood is a social-moral thesis. This thesis argues that the community provides the norms and material conditions for individuals to live a meaningful life and achieve personhood, and achieving personhood involves being integrated into, and contributing positively to the harmony of, the community.Keywords: Menkiti, Gyekye, Matolino, Personhood, Community, Moderate Communitarianism, Radical Communitarianism
The politics of limited communitarianism
Authors: Matolino Bernard
Published: October 2018

The debate on the communitarian notion of personhood as initiated by Gyekye, in response to Menkiti, is both exhaustive and exhausted. Its exhaustiveness and exhaustion lies in the fact that, in all probability whatever can be said around it has been said, with truly nothing new likely ever being added. What is possibly left, is the potential for further additions to be more strident in their picking of sides or repeating that Gyekye and Menkiti are not sufficiently different or insisting on the authenticity of either approach to African thought. What is needed is to transcend the constraints of this debate by opening up new vistas of interpreting communitarian thought in personhood. Whatever merit there is in showing whether radical or moderate communitarianism is real, or in showing which of these two is better than the other, this discussion can be furthered by looking at implications of communitarianism to other facets of philosophy. The most plausible avenue that could be implicated in communitarian considerations is the sphere of politics. Theorising about the communitarian notion of persons, I suggest, is partly to theorise about the political. If the commitments on which the doctrine of communitarianism is founded, are used to capture the sort of relations that exist between individuals, and between individuals and the community, then this relationship has an effect on how we conceive of the political theory we think appropriate. It is suggested here that contemplating on the communitarian polity will show the shortcomings of communitarianism as conceived by Gyekye and Menkiti.Keywords: Menkiti, Gyekye, Communitarianism, Limited Communitarianism, Personhood, Classical Communitarianism