bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolation and identification of microbiota from Egyptian common insect pests invading economically important crops
Authors: Elkhateeb Waill A. , ELnahas Marwa O. , M. Mousa Kareem , A. Ahmed Adel , ALKolaibe Abdu Galib , M. Daba Ghoson
Published: December 2021

Insects bodies contain multiple distinctive microbial colonies which play key role in the metabolism, development and health of an insect. In the current study bacterial and fungal microbiota were isolated from larval feces and adult wings of two major insect pests in Egypt, the Cotton leaf worm Spodoptera littoralis and the black cutworm Agrotis ipsilon. Isolated pathogens were identified and characterized according to the scientific described methods in such cases. Two different genera of bacteria (Bacillus & Serratia) were isolated from larval feces of both insects while isolated fungus were Paecilomyces variotii and Absidia corymbifera from the feces of A. ipsilon larvae, while Rhozopus stolonifer and Penicillium chrysogenum were isolated from adults wings of the same insect. The fungus Aspergillus flavus, Aspergillus niger and Mucor circinilloides were isolated from feces of S. littoralis larvae. Numerous species of bacteria and fungi had been documented as a bio-agent against many insect pests, and most of them exhibited disruption in life-cycle of different species of Lepidopterous pests. The obtained data sheds light on microbial colonies associated with two major insect pests, however further studies are required to involve the isolated microbiota in the biological control programs of insect pests.
Phytochemical Analysis and In-vitro Anti-Diabetic and Anti- Inflammatory study of root extract of Apama siliquosa LAMK.
Authors: Jose Manu , Baby Stephin , Mathew Dona , Muhammed Naurin , P M Jayalakshmi
Published: December 2021

The demand for herbal medicines in many pharmaceutical sectors is growing at a drastic rate due to their improved pharmacological actions, minimal side effects and cost-effectiveness. Anti-inflammatory phytochemicals are found to be efficacious against the treatment of inflammatory diseases like rheumatoid arthritis, glomerulonephritis, hepatitis, inflammatory bowel disease, etc. Anti-diabetic phytochemicals are found to treat the increasing incidence of diabetes prevalent globally. This work aims to perform the phytochemical screening and to evaluate the antidiabetic and anti-inflammatory activity of crude extract of Apama siliquosa Lamk. The method employed for obtaining the active principles includes soxhlation technique with methanol as solvent. The anti-inflammatory property was studied in vitro using inhibition of albumin denaturation technique as well as heat-induced hemolysis and IC50 value was found to be 39.5μg/ml and 36.30μg/ml respectively. The anti-diabetic activity was estimated using the alpha-amylase inhibition assay and Glucose diffusion inhibitory study. The IC50 value for alpha-amylase inhibition assay was found to be 15.75μg/ml. It also shows a strong inhibition of glucose across the dialysis membrane.
Stability Study of fast Disintegrating tablets of Nisoldipine as per ICH Guidelines
Authors: Saini Seema , Garg Rajeev
Published: December 2021

The stability study is a critical parameter to be evaluated in a pharmaceutical product development cycle. A pharmaceutical scientist pays a great deal of heed in testing a product stability. The present research work focused on conducting stability study of fast disintegrating tablet batch of Nisoldipine (NFDT). The various parameters evaluated were weight, hardness, friability, disintegration time, drug content and % drug released. The stability study of optimized fast disintegrating tablet batch NFDT was performed according to ICH guidelines. For the study plan, fast disintegrating tablet batch was placed in a wide mouth air tight containers, which were charged into the stability chamber. The temperature was adjusted at 40°C ± 2°C and relative humidity of 75% ± 5%. The study period was of 6 months. The fast disintegrating tablet batch NFDT did not showed any significant difference in weight, hardness, % friability and disintegration time. The drug content was also reported to be in limits of acceptance. The % drug released at various time intervals was insignificantly changed during its storage period. Hence, the prepared tablets were stable during their storage period.
Phytochemical analysis of ethanolic extract of leaves of Caesalpinia bonducella
Authors: P. Ezhilarasan , S. Sivakrishnan , Anbiah S.Vigil
Published: December 2021

Bioactive chemicals of plant source are phytochemicals (secondary metabolites). They are synthesized naturally in all segments of the plant. Caesalpinia bonducella used for psoriasis care by traditional Siddha physicians in the Malabar regions and is also used in Pakistan's traditional medicine scheme. Tree bark has been identified as a purgative and is recommended for the treatment of disorders of the kapha and vata, gynaecological disorders, skin infections, bowel problems, abdominal distension, piles, ulcers. This study is concerned with the phytoconstituents assessment of the ethanolic extract of Caesalpinia bonducella (EECB) leaves. Method: Using Soxhlet apparatus, coarse powder of Caesalpinia bonducella leaves was extracted with ethanol by hot percolation. For 24 hours, the extraction has been worked out. The solvent was extracted out for acquiring a concentrated extract following extraction. The condensed extract was then vacuum dried and the dry extract was processed for specific bioactive compounds investigation in an air tight container. The existence of alkaloids, carbohydrates, proteins & amino acids, hormones, phenols, tannins, flavonoids, glycosides and saponins was revealed in EECB.
Analytical Method Development and Validation for Telmisartan, Chlorthalidone and Amlodipine by UV- Spectroscopic Method.
Authors: M. Sanap Rutuja , R. Wavhale Sarika , V. Kunjir Vaibhavi , V. Shete Rajkumar
Published: December 2021

A simple, sensitive and accurate UV- spectrophotometric absorption correction method has been developed for simultaneous determination of Telmisartan, Amlodipine and Chlorthalidone in combined tablet dosage form. Analytical method development and validation plays important role in the discovery manufacture of pharmaceuticals and development. In this paper, absorption correction method is used for multi-component analysis. The wavelengths selected for the analysis were 311nm for Telmisartan, 228nm for Chlorthalidone and 253nm for Amlodipine. Beer’s law obeyed the concentration range of 2-10 µg /ml, 2-10 µg /ml and 5-25 µg/ ml for Telmisartan, Amlodipine and Chlorthalidone. Methanol is used as a solvent. The accuracy of the method was assessed by recovery studies and was found between the range of 100% to 110% for Telmisartan, 85% to 110% for Amlodipine and 85% to 105% Chlorthalidone. The % RSD value was found to be less than 2. Thus, the method was simple, precise, economic, rapid, accurate and can be successfully applied for simultaneous determination of Telmisartan, Amlodipine and Chlorthalidone in combined tablet dosage form.
Assessment of Drug related problems Encountered in Patients with Psychiatric disorders in a Secondary Care Hospital.
Authors: Shareef Javedh , Rao Padma GM , Ayman Al-Bonni Itaf Mohamad , Khudhaier Riadh
Published: December 2021

Introduction: Patients with psychiatric disorders receives multiple medications associated with their comorbid conditions and mental illness increasing the risk of drug related problems leading to frequent hospitalization, healthcare expenditure and reduced quality of life. Aim/Objective: To assess and evaluate the Drug Related Problems (DRPs) encountered in patients with psychiatric disorders in a Secondary Care Hospital in Ras Al-Khaimah. Methodology: A prospective observational study was carried out for a period of six months in the department of psychiatry of a secondary care teaching hospital. All the necessary details including the demographics, drug therapy and laboratory parameters were collected from the patient case records. The patient medication orders were reviewed and screened for any DRPs. The identified DRPs were documented and later evaluated to identify the types, frequency, class of drugs involved and for the level of clinical significance by using the descriptive statistics. Results: A total of 61 DRPs were identified from 50 patients. Male predominance was noted over females. DRPs were commonly seen in patients aged between 21-40 years of age. Schizophrenia (42%) was the most common psychiatric illness identified in the study. The most common DRPs was found to be drug-drug interaction (36.06%) followed by adverse drug reaction (27.86%) and medication non-adherence (24.59%). The level of significance of DRPs was found to be ‘minor’ significance in the grade. Conclusion: The study identifies the DRPs in patients with psychiatric illness and necessitates the need for a regular medication review which will help to rationalize the drug therapy, achieve better therapeutic outcomes and improved quality of patient care.
Bone Grafts: An Overview of Bone Remodeling, Types and Recent Advances
Authors: Krishna Ganta Gopala , Krishna Alla Rama , Cheruvu Kamala , Ram Guduri Bharathi
Published: December 2021

Bone grafts are often used to retrieve the lost bone in the most acceptable, technical and skilful manner that enables to restore the form and function of the bone. Numerous bone graft materials have been developed to fill and/or remodel the bony defects. Though, autografts were considered to be the gold standard among the grafts available; they have got some inherent disadvantages. The current research is more focused on allografts, which addressed the problems associated with autografts. This article provides an insight into the remodeling process, and various types of bone grafts currently available. Also, the emphasis was given on the recent advances of the bone grafts.
Phytochemical constituents, Ethno medicinal properties and Applications of Plant: Litsea glutinosa (Lour.) C.B. Robinson (Lauraceae)
Authors: Singh Chawra Himmat , Gupta Gaurav , Kumar Singh Santosh , Pathak Sachchidanand , Rawat Sarita , Mishra Anurag , Gilhotra Ritu M
Published: December 2021

Litsea glutinosa is popular in tropical and subtropical regions around the world such as India, Japan, Taiwan and many parts of China. Litsea glutinosa plant has many important medicinal properties and it is traditionally used for many gastrointestinal ailments and diseases like abdominal pain, indigestion, diarrhea as well as gastroenteritis and diabetes, edema, traumatic injuries colds, arthritis and asthma. Litsea plant is also known for its essential oil, which provides protective action against so many different types of bacteria. This plant has antioxidant and anti-parasitic properties and eliminates acute and genetic toxicity and cytotoxicity, thereby helping to prevent many cancers. This review captures the ethnographic properties, phytochemical components, uses, medicinal applications and health benefits of very important Indian indigenous plant “Litsia glutinosa” and emphasizes in-depth review to highlight the major and enormous potential found in this traditional medicine. Due to non-domestic and dioecious nature of plant immediate attention to the conservation strategies of the plant is required. It aims to provide insights into our Knowledge gaps that are very necessary for this type of medicinal important plants. It can be a very viable approach and in-depth research for the long-term benefits of society.
Iresine herbstii: An Overview
Authors: Jaafar Noor S , Jaafar Iman S
Published: December 2021

Iresineherbstii (blood leaves) is a member of the Amaranthaceae family, native to tropical and subtropical areas. It is erect herbaceous, has red and white variety. Different phytochemical constituents were detected as alkaloids, flavonoids, anthocyanins, and others. This herb was used as a pH indicator, insecticide, and dye fabrics. Traditionally it was used for divination purposes and other purposes. Iresinin IV is the major colorant. Different studies were done to evaluate the CNS, immunomodulatory, antibacterial, antiviral, cytotoxic and other effects. Fresh leaves extract was hepatotoxic. This review aimed to demonstrate the morphological features of this herb and to show the clinical studies related to its traditional use.
Substantiation and Selection of Promising Medicinal plants for prevention of diseases of Springer cows (Review)
Authors: Ulrikh Elena Victorovna , Zubova Tatyana Vladimirovna , Konstantinova Olga Borisovna , Smolovskaya Oksana Vladimirovna , Izhmulkina Ekaterina Aleksandrovna
Published: December 2021

Medicinal plants and phytopreparations on their basis have been for a long time used for prevention of numerous diseases of springer cows. Phytobiotics supply a set of biologically active substances into organism, including micro- and macroelements. In comparison with synthetic preparations, the phytobiotics and bioadditives based on herbal stuff are characterized by certain advantages: lower risk of allergic reactions, soft effect, wide therapeutic action, efficiency and safety for use upon management of springer cows.
Novel Nanoproniosomal Vesicular carriers for the effective and efficient Drug Delivery: Fundamentals, Recent Advancements and Applications
Authors: Sabareesh Mekala , Pedda Yanadaiah Janapati , Bannoth Chandrasekhar Kothapalli
Published: December 2021

Nanotechnology is an emerging technology that has brought the upheaval reforms in the domain of pharmaceutical sciences including the development of nanovesicular drug delivery carriers such as proniosomes, niosomes, liposomes, ethosomes, etc. Among them, proniosomes become superior and they surmount the problems of other vesicular carriers. Proniosomes are nano-sized vesicular structures of dry, free-flowing powder (or) gel with encapsulation of drugs in the vesicle that produce multilamellar niosomal dispersion after hydration and they possess the capacity to enhance solubility, permeability and bioavailability of diverse drugs. Proniosomes are suitable to deliver the drugs efficiently through transdermal route to accomplish controlled release action, increased therapeutic effectiveness to various diseases and upon application to the skin, the proniosmes are modified into niosomes in situ by hydration of water from the skin. This study aims to discuss different aspects of proniosomes such as merits, mechanism, types, components, preparation, characterization, drug release, market scenario, future trends and to explore proniosomes for various pharmaceutical applications in drug delivery via different routes, such as topical, transdermal, oral, parenteral, ocular, vaginal, nebulizer and intranasal routes. These proniosomes-derived niosomes are better and may offer an excellent, inexpensive alternative delivery, much more beneficial than other vesicular and conventional dosage forms.
Development and Validity of Questionnaire for Healthy Adult Human Participants of Early Phase Bioequivalence Pharmacokinetic Endpoint Study
Authors: Desai Sharad , Patel Nilesh
Published: December 2021

Participation of humans in clinical research is always remained questionable. Hence evaluation of such doubt helps to conclude the perception about such participation. This research presents the process for development and validation of questionnaire for Healthy Adult Human Participants of Early Phase Bioequivalence Pharmacokinetic Endpoint Study. For development of questionnaire, literature search, experts’ discussion and authors’ experience was used for domain identification and its segregation for different variables. For validity of questionnaire, face validity and content validity was performed. Modification was done based on response from experts during non-quantitative face validity. % of overall agreement was 94.55 for question asked in face validity. While, Content Validity Ratio and Content Validity Index was calculated using the process mentioned by Lawshe and Lynn respectively. Initially 83 items were identified but based on validation 84 items were finalized after removal of three and addition of four questions. Deleted three items had Content Validity Ratio of 0.00, 0.67 and 0.67 and which were below accepted level of 0.99. While, I-CVI was observed from range of 0.83 to 1.00 and S-CVI values were above acceptable level of 0.90 for S-CVI (S-CVI/ Ave) and 0.80 for S-CVI (S-CVI/UA) for whole questionnaire and each part.
Independence of the axioms of hypergroup over the group
Authors: Navasardyan Shant
Published: December 2021

The independence of the axioms of hypergroup over the group is proved. The proof is composed of two parts. In the first part, the independence of the axioms $(P3)$, $(A1)$, $(A3)$, $(A5)$ in the system of axioms of hypergroup over the group is shown by fixing the structural mappings $\Phi$ and $\Xi$. In the same way, in the second part of the proof, the independence of the axioms $(P1)$, $(P2)$, $(A2)$, $(A4)$ is shown by fixing $\Psi$ and $\Lambda$.
Reflections on Direct Access to the African Court on Human and Peoples’ Rights: A Cul De Sac?
Authors: Tambasi Netya Sidney , Gathoni Miano Cynthia
Published: December 2021

Individuals and NGOs can directly access the African Court on Human and Peoples’ Rights if the state against which a case has been filed has made an optional declaration granting this access. Alternatively, they can access the Court if the African Commission on Human and Peoples’ Rights refers communications to it. However, two main barriers have riddled this structure. One, the few states that had made the optional declaration have begun to rapidly withdraw from it. Two, the African Commission, which was expected to mitigate such a situation where few states are making the optional declaration, is hardly referring cases to the Court. This paper examines these two barriers in tandem. It argues that if this status quo is sustained, then, sooner rather than later, this path treaded may lead the African human rights system to a cul-de-sac – back to a one tier system, composed of an accessible Commission and a Court inaccessible to both individuals and NGOs. Drawing lessons from the European and Inter-American Human Rights system, it recommends preventing this eventuality by amending the African Commission’s 2020 Rules of Procedure to provide for a default procedure of referral of cases from the Commission to the Court.
Ambiguous effects of minimum wage tool of labour markets regulation – key study of V4 countries
Authors: Jasova Emilie , Kaderabkova Bozena
Published: December 2021

In this paper we analyze the effect of minimum wage change on selected labour market indicators such as duration of employment, hours worked, unemployment by education or profession or long-term unemployment. Our research is based on Eurostat and OECD data for V4 countries. The hypothesis discussed is whether the effect of minimum wage increase is positive or negative and we discuss the issue of economic regulation more generally. The output values of the regressions coefficients of all the V4 countries showed that the effects are more positive than negative. Mapping the overall intensity of effects of the minimum wage on selected indicator of the labour market in the Czech Republic and Hungary indicated a low sensitivity. The effects were very weak in Slovakia and Poland. The results of the analysis complied with the results of the domestic and international research in 13 cases and the results were different in 6 cases. Slightly more often they confirmed more positive effects of the minimum wage on selected indicators of the labour market than negative effects.
Multilevel research of migration with a focus on internal migration
Authors: Kurekova Lucie , Hejdukova Pavlina
Published: December 2021

In the research of migration, we can encounter the application of multidisciplinary approaches with the use of knowledge from existing theories, which implies the need for statistical reporting. It is not always easy to determine who a migrant is, and studies exploring migration can be dividing up according to many criteria. Contemporary literature contains a whole score of studies dealing with migration, its determinants and impacts on the economy, etc. However, there are very few studies dealing primarily with regional (i.e. internal) migration in comparison to the number of studies analyzing international migration. The goal of this study is to point out problems in reporting migration and to propose a strategy to analyze migration based on multilevel research of migration while making this strategy applicable to internal migration.
EFFECTS OF DEMOGRAPHIC STRUCTURE IN GROWTH ACCOUNTING AND LABOUR MARKET DECOMPOSITIONS
Authors: Malecek Petr
Published: December 2021

Impact of demographic structure on labor market and macroeconomic aggregates might be pronounced in some countries. Despite this fact, only a handful of approaches dealing with quantifications such effects have been derived so far. The aim of this paper is therefore to fill this methodological gap and to introduce methodological approaches for capturing changes in demographic structure, with many applications in growth accounting and labor market decompositions. Firstly, a novel additive decomposition will be presented, as an alternative to traditional models using fixed population weights. This will be followed by the presentation of a multiplicative decomposition, which can be applied to all kinds of growth accounting exercises based on multiplicative identities.
Pupils as subjects or objects: Policy changes in the area of pupils influence
Authors: Eriksson Linda , Eriksson Linda
Published: December 2021

The aim of this article is to describe and analyse how policy changes in the three latest Swedish compulsory school, preschool class, and school-age educare curricula affect the political goal of pupil influence. This is done with an interest in implications for utterances of power relations and for didactical considerations for living and learning democracy in school. This article analyses pupil influence by using theories of democracy, power, and didactics. The method used is content analysis. The empirical results show that pupil influence in the curricula is linked to seven concepts: democracy, value, norm, rights, responsibility, influence, participation. Our conclusion is that only small differences exist in terms of the central concepts mentioned in the curricula linked to pupil influence. Secondly, we found a policy shift with respect to the pupils, i.e., viewing pupils as subjects or objects. Thirdly, we found a shift in how learning is viewed in the curricula and the type of didactical questions that are in focus, which illuminates a change in utterances of power relations that challenges possibilities for living and learning democracy in Swedish school education.
الأنماط الاستهلاكية للألبان و منتجاتها في ولاية الخرطوم
Authors: ناهد محمد توفيق فاوي
Published: December 2021

الأنماط الاستهلاكية للألبان و منتجاتها في ولاية الخرطوم

This research aimed at identifying the different consumption trends of the Sudanese individual in regard to fresh milk and dairy products.

It also aimed at making use of studying the behavioral consumption in the marketing field and to set a future prospectus to accomplish development and quality in dairy marketing in Sudan.

To achieve such aims a number of hypothesis were tested through analysis of data collected from families in Khartoum state different statistical methods were implemented.

Several results were concluded, of which are: 1 .Fresh milk has high acceptance among Sudanese consumers.

2.

The consumer has low trust in the quality of fresh milk sold by roaming sellers.

3.

The Sudanese consumer has low nutritional and health awareness about the value of dairy products (other than white cheese & yogurt).

The study was concluded with several recommendations, of which are: 1.

Adapting modem marketing concepts by giving more attention to consumer needs and demands and benefiting from Sudanese consumers' general food culture in the marketing procedure.

2 .

Performing marketing research on consumption patterns and habits of the Sudanese individual to benefit out of them in dairy marketing
A review on lead toxicity in Khartoum State-Sudan
Authors: Abd al-Rauf Ahmad Abbas
Published: December 2021

A review on lead toxicity in Khartoum State-Sudan

This article is an extensive review for lead toxicity in the Sudan.

It reveals that a little has been done in this important issue in the Sudan, compared to other countries.

Some researches appear in this review, have studied lead poisoning in school children, citizens of Khartoum state, occupational districts( such as printing presses) and Lead (Pb) concentration in air, food and some Nile fish Species.

The results of this J study, indicate an elevated levels of lead in the Sudan, compared to the standard levels in other countries such as USA and Germany
Pelatihan perawatan/service AC untuk masyarakat sekitar Politeknik Penerbangan Indonesia Curug
Authors: Arnas Yenni , M. Ismail KGS. , Kurniawati Zulina , Kurnianto Benny , Haryadi Wibowo Imam , Kalbuana Nawang
Published: December 2021

The trend of using air conditioners, air conditioners or called AC (Air Conditioner) is increasing in the community both in offices and in housing. To keep its performance, air conditioning should be maintained regularly according to the intensity procedure. Hence, the air conditioner can stabilize the air temperature and humidity of the area in accordance with its specification. As the demand for maintenance is growing, the opportunity to become an AC technician is also increasing. Carrying out basic training in AC maintenance can assist people who are interested to become AC technicians. Training participants are expected to gain knowledge of AC installation, AC components and working principles, AC maintenance, and safety standard.
BRAIN ACTIVITY AND CONNECTIVITY IN 11C-PIB PET MCI AND HEALTHY ELDERLY INDIVIDUALS AFTER COGNITIVE TRAINING
Authors: Miotto Eliane
Published: December 2021

Background: Cognitive training (CT) can benefit mild cognitive impairment (MCI) people. However, no study has explored its effects in MCI patients with amyloid biomarkers. Objectives: to investigate brain correlates and connectivity after CT in MCI patients with 11C-PIB PET+/- and healthy controls (HC). Methods: 25 participants PIB+ (n=8), PIB- (n=8) and HC (n=9) were included. They underwent 6 sessions of CT using visual imagery to recall newspaper reports and scanned with fMRI before and after CT using a newspaper encoding paradigm. We used 3TMR, FSL, one seed in the right and in the left hippocampus for resting state. Results: Before CT, all participants showed activation in the left precentral and fusiform gyrus, bilateral occipital cortex and cerebellum (Fig 1-A). HC and PIB- individuals showed left hippocampus, inferior frontal gyrus and intraparietal cortex activation. After CT, HC showed bilateral hippocampus activation (Fig 1-B), PIB+ had a new cluster of activation in left hippocampus. HC showed increased connectivity between right hippocampus and left parietal, pre and post-central gyri (Fig 1-C). Conclusions: There were different brain beneficial effects of CT with bilateral hippocampus recruitment for HC and in the left hemisphere for PIB+. These findings may suggest specific functional compensation mechanisms related to CT in this population.
NEURAL CORRELATES OF WORD AND NONWORD READING PROCESSES IN TYPICAL AGING: A FNIRS STUDY
Authors: Lunardi Brenda , Lukasova Katerina , Goulart Maria Carthery-
Published: December 2021

Backgroud: Phonological and lexical-semantic processes in the elderly population still needed be investigate specially to understand how neural plasticity and compensatory mechanisms influence these processes. Objective: The functional near-infrared spectroscopy (fNIRS) has been increasingly used in language studies to observe cortical activity. Methods: In the current study, we characterize the performance of this population in naming and reading tasks and explore their neural correlates. 32 healthy elderly adults (age 69.1±5.9) performed word/nonword reading aloud and oral naming tasks, with concomitant fNIRS recording. We compared task condition vs rest blocks in anterior and posterior temporal (ATC, PTC), dorsolateral prefrontal (dlPFC), inferior frontal (IFC) and inferior parietal (IPC) cortices, bilaterally. Results: We found lexicality and regularity effects modulating word reading fluency (p <.001). No difference was observed in naming and nonword fluency. We observed cortical activity only in dlPFC for nonword, in ATC and PTC for irregular words, in dlPFC and PTC for regular words and in dlPFC and IPC for naming (p<.05). No lateralization was observed in any condition. We verified a positive correlation between reading fluency and dlPFC activity (p <.02). Conclusion: Our findings supporting the dual-route models and indicate compensatory neural mechanisms in aging.
DEVELOPMENT OF THE BRAZILIAN MINI-ADDENBROOKE’S COGNITIVE EXAMINATION (MINI-ACE BR)
Authors: Oliveira Maira Okada De , Goulart Maria Carthery- , Freitas Karolina César , Nitrini Ricardo , Brucki Sonia
Published: December 2021

Background: Age is the most important risk factor for development of dementia and the recommendation is that the elderly be cognitively tested in order to detect impairment in the initial phase for adequate treatment. The demand for the care of these elderly people is great, drawing attention to the need for rapid tests, with good accuracy and simple application to identify cognitive impairment. Objective: To develop the M-ACE Brazilian version using data from ACE-R deriving sub-items that could better predict the diagnosis of cognitive impairment. Methods: The M-ACE BR was developed using Mokken scaling analysis in 352 participants (cognitively normal = 232, cognitive impairment no dementia (CIND) = 82 and dementia = 38) and validated in an independent sample of 117 participants (cognitively normal = 25, CIND = 88 and dementia = 4). Results: The M-ACE BR has nine items (spatial orientation, anterograde memory, retrograde memory, delayed recall, recognition, verbal fluency letter “P”, repetition of four words, naming 10 items and comprehension) with a max. score of 51 points and average duration time of seven minutes. The cutoff score ≤43/51 for CIND had a sensitivity of 59.09% and a specificity of 80%. For a screening test in which sensitivity is prioritized for further investigation, we suggest using a cutoff of ≤47 (sensitivity 85.23% and specificity 24%), maintaining a good positive predictive value (79.8%) Conclusion: The M-ACE BR is a brief and adequate instrument for detecting cognitive impairment in elderly Brazilians.
MENTALIZING IN FRONTOTEMPORAL DEMENTIA AND PROGRESSIVE SUPRANUCLEAR PALSY
Authors: Souza Leonardo de , Bertoux Maxime , Mariano Luciano , Resende Elisa , Teixeira Antônio Lúcio , Cardoso Francisco , Camargos Sarah , Tumas Vítor , Caramelli Paulo
Published: December 2021

Background: Mentalizing and emotion recognition are impaired in behavioral variant frontotemporal dementia (bvFTD). It is not clear whether these abilities are disturbed in progressive supranuclear palsy (PSP). Objective: To investigate social cognition (SC) between bvFTD and PSP. The neural basis of SC in PSP and bvFTD groups were also investigated by neuroimaging. Methods: Data from the notification sheet were collected and patients were classified according to current clinical and pathological criteria. Results: Groups did not differ on age, schooling and sex. Compared to controls, bvFTD and PSP patients had reduced scores in all tests of SC. bvFTD and PSP did not differ on measures of SC. PSP and bvFTD had cerebral atrophy in critical regions for SC. The cortical correlates of emotion recognition overlapped in bvFTD and PSP, correlating with frontal medial cortex, insula and limbic structures. PSP and bvFTD patients also displayed similar patterns of brain correlations (anterior temporal lobes) for social norms. The neural correlates of mentalizing were associated with frontal and temporal poles bilaterally, in both bvFTD and PSP. Conclusion:PSP patients exhibit impairment in mentalizing. PSP and bvFTD share clinical, cognitive and neuroimaging features.
AT(N) MODEL AND ITS ASSOCIATION WITH NEUROPSYCHOLOGICAL MARKERS
Authors: Mariano Luciano , Salvador Larissa , Peles Patrícia , Friedlaender Clarisse , Carvalho Viviane , Santos Etelvina dos , Souza Leonardo de , Caramelli Paulo
Published: December 2021

Background: The National Institute on Aging and Alzheimer’s Association (NIA-AA) proposed the AT(N) model to diagnose Alzheimer’s disease (AD) considering some biomarkers: amyloid beta (A), phosphorylated tau (T), and neurodegeneration (N). Still, AT(N) correlation with cognitive markers is not yet covered. Objective: To investigate the neuropsychological profile of patients with CSF biomarkers according to AT(N) classification. Methods: Sixty-five patients with thorough neuropsychological data and results of CSF biomarkers were included in the study. We performed a cluster analysis using biomarkers results. The validity was checked by neuropsychological tests scores. Results: We found three clusters: Cluster 1 (n=24), classified as non-AD; Clusters 2 (n=9) and 3 (n=32), classified as AD. Cluster 2 had a higher burden of phosphorylated tau and total tau. All groups were similar regarding sociodemographics and functionality. AD groups had worse memory deficits than the non-AD cluster, but Cluster 2 was more affected than Cluster 3. No other cognitive difference was found, except in the Cubes subtest (Cluster 3>Cluster 2).Conclusion: Memory was the sole domain able to discriminate AD from non-AD, probably due to Cluster 1 heterogeneity. Further studies are warranted to explore this hypothesis. A smaller cluster with AD shows variability in the biomarker profile, which is relevant given its worse cognitive scores.
Da sociedade ao indivíduo e de volta à sociedade: socialização e individuação em G. H. Mead
Authors: Casagrande Cledes Antonio
Published: December 2021

Este ensaio tem por tema central os processos de socialização e de individuação em George Herbert Mead. Trata-se de um texto teórico e hermenêutico, com fins propedêuticos, ligado ao campo da filosofia da educação. O objetivo consiste em discutir como Mead, em seus escritos, compreende e descreve os processos de formação dos sujeitos sociais, e quais as possíveis correlações desses processos com a capacidade de viver em comunidade, sob a égide da ética e da democracia. No texto, argumenta-se que o processo de formação do self remete à socialização individuadora, e que a emergência da consciência do ‘si mesmo’ somente é possível por meio da interação e da participação efetiva na vida da comunidade. Por isso, é possível ponderar que a incapacidade de pensar e agir desde uma perspectiva social representa um déficit formativo, de reponsabilidade do próprio indivíduo e também da sociedade.
Produzir e compartilhar: a produção de professores da educação básica no YouTube
Authors: Lucena Simone , Da Mota Gersivalda Mendonça , Santos Sandra Virginia Correia de Andrade
Published: December 2021

Este artigo é resultado de uma pesquisa que buscou compreender as possibilidades de utilização do Youtube na educação, envolvendo uma proposta de criação e cocriação de vídeos, junto aos professores da educação básica. A metodologia utilizada foi a pesquisa-formação, a qual requer do pesquisador uma implicação com os sujeitos e com os dispositivos da investigação. Nesse sentido, foi criado um dispositivo autoral de formação continuada docente, a oficina “Possibilidades do uso da rede social Youtube na educação”. A pesquisa-formação tem como aporte teórico Josso (2010), Macedo (2009, 2010) e Santos (2014). Os dispositivos para levantamento de dados foram: observação, diálogo com os participantes e diários de campo. Como resultado, verificou-se que nem todos os professores se apropriaram da dinâmica de criação e/ou cocriação de vídeos, bem como do compartilhamento de suas produções. Alguns demonstraram insegurança e resistência. Desta forma, concluímos que a ausência de práticas autorais e dinâmicas, por parte dos professores envolvidos, está relacionada principalmente a dois fatores: dificuldade de imersão na cibercultura e de disponibilidade para a realização de atividades de formação continuada, pois as políticas educacionais, seja no nível municipal, estadual ou federal, não têm possibilitado para que os professores tenham disponibilidade para realizar sua formação continuada.
A educação como socialização em Émile Durkheim
Authors: Soares Rhuany Andressa Raphaelli , Weiss Raquel Andrade
Published: December 2021

O presente artigo tem como objetivo abarcar a centralidade da temática da educação na obra do Sociólogo francês Émile Durkheim. Em um primeiro momento, pretende-se demonstrar de que forma o autor, a partir de sua concepção de ciência da educação, compreendeu o fenômeno educativo como fundamental tanto para a manutenção e continuidade do meio social quanto para a formação dos indivíduos como membros de uma sociedade. Para Durkheim, a educação teria como função substancial transmitir o legado sociocultural de um determinado contexto, tendo como resultado um processo de socialização que possibilitaria a constituição do que ele denomina de “ser social”. Por fim, apresentamos de que forma a educação dialoga diretamente com a questão da moralidade e seus elementos constitutivos e como os escritos durkhemianos sobre o tema se colocam como ponto de partida para pensar questões e problemáticas atuais sobre os processos educativos, tendo como exemplo o tema da diversidade.
Utilization of Moringa oleifera as Natural Coagulant for Water Purification
Authors: Ng Meng Hong , Elshikh Mohamed Soliman
Published: December 2021

The plant-based natural coagulant has the potential to substitute the chemical coagulant in the water treatment process. In this work, the potential of plant-based natural coagulants in the ability of turbidity removal was identified. The Moringa oleifera seed was selected for the batch analysis test such as pH, contact time, agitation, and dosage. The high alkaline water decreases the effectiveness of plant-based natural coagulants. The agitation and contact time show the importance of the coagulation process. The optimum turbidity removal rate in pH is 4, the contact time is 60 seconds and 3000 seconds for coagulation and flocculation, respectively, the agitation is 300 RPM and 30 RPM for coagulation and flocculation, and lastly, the dosage is 10 g of Moringa oleifera seed. Finally, the plant-based natural coagulants demonstrated the ability to remove turbidity and could be used in place of chemical coagulants.
Szakony-Kavicsbánya cemetery from the age of the Hungarian conquest
Authors: Horváth Ciprián
Published: December 2021

In the spring of 1961, a graveyard with 7 graves from the age of the Hungarian conquest was found in a gravel pit near Szakony. The graves of 1 man, 2 women and 4 children were documented in the fully excavated cemetery. The nature and geographical location of the site have already attracted particular attention during the research, helping to determine the former extent of the settlement area. Biochemical research identified consanguineal relations between the deceased, thus research often identifies this site to date as a small-family cemetery. It was mainly the finds from horse burials that attracted attention in the material, and it is in this cemetery that the presence of metal-mounted harnesses used by men was first observed authentically. The observations regarding the female grave (no. 6) led to the first authentic reconstruction of a saddle decorated with silver plates too. The research also revealed the Carolingian origin of a harness ornament from grave 7, and almost exact Eastern European parallels of one of the rosette mounts. A new and interesting combination was the olive bead and the plate button from grave 6, examples of the former have only recently become known from Hungarian cemeteries previously thought to be devoid of finds in this respect. No less interesting is the question of the Eastern European parallels of harness mounts or parts of them, which do not exclude the possibility that they were made further east of the Carpathian Basin. But it cannot, of course, be ruled out that the similarities can be interpreted as traces of a system of contacts with the East that existed in the 10th century. Perhaps the former possibility cannot be dismissed either, together with the dating of the cemetery to the end of the 9th century and the early decades of the 10th century, as suggested by scientific dating. In the case of the deceased, the archaeogenetic analysis of the assessable samples refuted the existence of any kinship links, so it is certain that it was not the members of a small family based on consanguinity who were laid to rest in the Répce Valley sometime in the early 10th century.
An archaeogenetic approach to identify the remains of the Hungarian Kings. Working Plan
Authors: Varga Gergely I. B. , Maár Kitti , Ginguta Alexandra , Kovács Bence , Tihanyi Balázs , Kis Luca , Váradi Orsolya , Kiss Petra , Szokolóczi Dávid , Schütz Oszkár , Maróti Zoltán , Nyerki Emil , Nagy István , Latinovics Dóra , Török Tibor , Neparáczki Endre
Published: December 2021

The Royal Basilica of Székesfehérvár was the burial place of fifteen Hungarian kings. Unfortunately, the anthropological findings excavated at the site of the Basilica were mixed up during the tumultuous centuries of Hungary, hence the royal remains still lie unidentified in a charnel-house. The appearance and rapid development of archaeogenetics now allows the personal identification of the royal skeletons from among the remains of the Basilica. The genetic information necessary for the identification of the Árpád dynasty members is accessible, while sequence data of the non-Árpádian kings’ relatives still need to be obtained by further genetic analysis. Here we provide an outline of the investigation for the identity of the royal skeletons: we sketch the process of sample preparation and DNA extraction, the steps of library preparation for next-generation sequencing (NGS) and give a brief report of the current progressions.
Relação entre sentido de vida e satisfação com a vida
Authors: Barros Leonardo De Oliveira , Moreira Thaline Da Cunha , Oliveira Dianniffer Aparecida , Noronha Ana Paula Porto
Published: December 2021

Esta pesquisa objetivou verificar a relação entre sentido de vida e satisfação com a vida. Participaram 901 pessoas, residentes em 25 estados brasileiros, dos quais 81,9% eram do sexo feminino. As idades variaram entre 18 e 77 anos (M=35,19; DP=11,9). Foi aplicado um questionário desenvolvido pelos autores e a Escala de Satisfação com a Vida (ESV). Foi possível observar que as pessoas que praticam alguma religião estão mais satisfeitas com a vida do que aquelas que não frequentam instituições religiosas. Em relação à escolaridade, indivíduos que declararam ter cursado Pós-Graduação apresentaram níveis mais altos de satisfação com a vida quando comparados com os que cursaram Ensino Médio e Ensino Superior. Além disso, os homens afirmaram mais frequentemente ausência de algo importante na vida. Os achados são discutidos à luz da literatura.
Zulliger na avaliação de crianças e adolescentes vítimas de abuso sexual
Authors: Gelain Denise , Gonçalves André Pereira , Villemor-Amaral Anna Elisa
Published: December 2021

O objetivo deste estudo foi verificar se existe diferença entre os grupos de crianças e adolescente vítimas de violência sexual intrafamiliar e não vítimas, nas variáveis autopercepção e relacionamento interpessoal do Zulliger utilizando a aplicação R-otimizada. Os resultados indicaram que nas variáveis de autopercepção apenas Sx + Xy foi marginalmente significativo na discriminação dos dois grupos. Considerando as variáveis que compõem o relacionamento interpessoal, COP foi capaz de discriminar os grupos, sendo que o grupo de não vítimas apresentou maiores médias, enquanto que AG, PHR, SumH foram maiores no grupo de vítimas. Além destas variáveis foram analisados os conteúdos críticos Bl e SX, ambos foram capazes de discriminar os grupos, com maiores médias para o grupo de vítimas. Estes resultados indicam que que o Zulliger pode auxiliar na avaliação das características de personalidade de vítimas de violência sexual e contribuir para a discriminação entre vítimas e não vítimas.
Validade Convergente entre Processos Cognitivos do Zulliger com Idade e Escolaridade
Authors: Bier Di Domenico Grazziotin Jucelaine , Alba Scortegagna Silvana
Published: December 2021

Este estudo buscou evidências de validade convergente entre indicadores do processamento cognitivo do teste de Zulliger com a idade e a escolaridade. Participaram 64 adultos não pacientes, entre 18 e 59 anos de idade (M = 30,14, DP = 10,33), prestadores de serviços comerciais. Utilizaram-se como instrumentos um questionário sociodemográfico e o teste de Zulliger no Sistema Compreensivo. Na comparação com a amostra normativa brasileira, houve aumento significativo nas variáveis do Zulliger que indicam capacidade de análise e síntese (DQ+, W, XA%), e rebaixamento significativo de indicadores que mostram percepção inadequada da realidade (X-%). A associação do Zulliger com as variáveis externas, a correlação significativa (W:M) mostrou tendência à produtividade aquém das capacidades, em adultos mais jovens. A escolaridade demonstrou associação significativa com criatividade e tomada de decisões (M, Ma:Mp). A convergência do Zulliger com idade e escolaridade potencializam o uso do instrumento e enriquece a compreensão de aspectos cognitivos de adultos.
Desempenho em planejamento, flexibilidade e controle inibitório em crianças com e sem TEA: Efeitos dos sintomas comórbidos de atenção e hiperatividade
Authors: Fabre Bárbara Dias , Lúcio Patrícia Silva
Published: December 2021

O Transtorno do Espectro Autista (TEA) é um transtorno do neurodesenvolvimento que provoca dificuldades em várias áreas, incluindo as funções executivas (FE), principalmente na presença de comorbidades. O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) é uma das comorbidades mais frequentes do TEA. A pesquisa identificou perfis de FE de crianças com e sem TEA e verificou o efeito da presença de comorbidade (TDAH) nesse perfil. A amostra foi composta por 16 crianças com TEA e 32 controles (mesma sala de aula; emparelhadas por idade, sexo e QI não-verbal). Foram avaliadas as funções de flexibilidade (Wisconsin), planejamento (Torre de Hanoi) e controle inibitório (Go/No-go) e os pais responderam ao SNAP-IV. Conduziram-se análises multi/univariadas (MANOVA e ANOVA) e testes de qui-quadrado. No contraste entre o grupo clínico e controle, não houve diferenças em flexibilidade ou em planejamento. Houve efeito geral no controle inibitório, que deveu-se a diferenças na condição No-go (> erro TEA). A análise de comorbidade (2x2; TEA/controle; TDAH presente/ausente) apontou que os sintomas de TDAH produziram diferenças em flexibilidade e em controle inibitório no contraste entre crianças com TEA+TDAH e controles sem TDAH. Discute-se as implicações dos resultados para a análise de especificidade dos transtornos.
Avaliação psicológica e envelhecimento humano: revisão de pesquisas
Authors: Chnaider Janaina , Nakano Tatiana De Cássia
Published: December 2021

O envelhecimento humano tem sido foco de interesse da Psicologia nas últimas décadas, se tornando uma de suas áreas de atuação emergentes. Nesse sentido, o presente estudo buscou analisar a produção científica sobre avaliação psicológica aplicada à população idosa. A busca nas bases de dados Scielo, Capes e Pepsic indicou a existência de 23 artigos que abordam a temática. Os resultados indicam que, de modo geral, as pesquisas ainda se mostram em número reduzido, e são provenientes de nove diferentes áreas de conhecimento e voltadas, principalmente, à investigação de aspectos cognitivos/inteligência, havendo interesse alto na depressão, ansiedade e aspectos neuropsicológicos, dentre outros. Pouca ênfase nos aspectos positivos e saudáveis foi encontrada nos estudos, de modo que se pode afirmar que o envelhecimento ainda continua sendo visualizado como uma fase marcada por perdas e declínios, ressaltando os aspectos negativos da velhice, não tendo sido absorvida ainda a concepção de envelhecimento bem-sucedido, concepção predominante na atualidade.