bluuebunny/crossref_metadata_2025 huggingface dataset:
Paediatric Crohn’s disease: histologic findings at initial presentation
Authors: Spasic Smiljana , Pankaj Amaya , Kaplan Jess L , Patil Deepa , Moran Christopher J , Deshpande Vikram
Published: July 2024

Background

Diagnosing paediatric Crohn’s disease (CD) based on histology can present challenges. We evaluate the histological spectrum of treatment-naïve biopsies from children with CD and assess these findings’ diagnostic and predictive value.

Methods

Three cohorts were identified: (1) 137 patients with CD, (2) 116 patients with ulcerative colitis (UC) and (3) 50 patients without inflammatory bowel disease. Biopsies from the gastrointestinal (GI) tract were re-examined for signs of active and chronic inflammation, including lymphocyte-pattern oesophagitis, focal enhancing gastritis and indicators of chronicity. Additionally, granulomas and microgranulomas (defined as clusters of 4–9 epithelioid histiocytes) were evaluated.

Results

Lymphocyte-pattern oesophagitis was observed in 15% of patients (n=20). Moderate-to-severe diffuse gastritis was noted in 50.4% of patients (n=68), while focal enhancing gastritis was identified in 11.1% (n=15). In terminal ileal biopsies, 46.1% exhibited activity and 5.3% showed features of chronicity. Active colitis was present in 73% of patients (n=100), with chronic colitis seen in 11.7% (n=16). Granulomas and microgranulomas were observed in 31.4% (43/137) and 48.9% (67/137) of patients, respectively. Notably, 30.7% (42/137) of patients with microgranulomas were without granulomas. Previously undetected microgranulomas were found in 20 of 27 cases. 2.5% of patients with UC and none of the control cohort showed microgranulomas. Lymphocyte-pattern oesophagitis was associated with an increased need for anti-tumor necrosis factor (TNF) therapy (p=0.007).

Conclusions

GI microgranulomas, often overlooked, are specific to CD in the proper clinical context. Oesophageal lymphocytosis may predict a need for more aggressive treatment. The study brings to light under-recognised aspects of CD’s histological diagnosis, including the oversight of microgranulomas, the high prevalence of diffuse gastritis and low prevalence of focal enhancing gastritis, the frequent absence of terminal ileitis and the infrequent occurrence of chronic colitis.
Digital innovative healthcare during a pandemic and beyond: a showcase of the large-scale and integrated Saudi smart national health command centre
Authors: Alharbi Muaddi F , Senitan Mohammmed , Mominkhan Dalia , Smith Sidney , ALOtaibi Maram , Siwek Michal , Ohanlon Tim , Alqablan Fahad , Alqahtani Sarah , Alabdulaali Mohammed K
Published: July 2024

Introduction

The increasing frequency of pandemics, demand for healthcare and costs of healthcare services require efficient health systems with integrated care via a command centre that ensures a centralised and coordinated approach to exercise effective leadership.

Description

We present a case study using the conceptual framework of Franklin to describe the novel system-based engineering approach of the Saudi National Health Command Centre (NHCC) including its features and outcomes measured.

Discussion

The NHCC is structured into four departments and four zones with real-time data integration and visualisation on 88 dashboards. To empower leadership, it harnesses artificial intelligence affordances such as machine learning algorithms to enhance functionality, decision-making processes and overall performance. This allows for the rapid assessment of available resources and to monitor healthcare system efficiency at diverse levels of clinical and system indicators. Enhanced proactive capacity management has contributed to reducing lengths of stay, average supply chain lead time and surgery waiting list; early bending of the COVID-19 curve resulting in a low mortality rate; increasing bed capacity; deploying medical staff and mechanical ventilators rapidly; rolling out the COVID-19 vaccination programme and improving patient satisfaction.

Conclusion

Integrating a healthcare system with a command centre provides healthcare leaders with the necessary infrastructure to create synergy between people, processes and technologies. This substantially improves both patient and service outcomes. It also allows for immediate care coordination and resource allocations and safeguards ease of access to care.
Awareness and perceived behaviour changes following the New York state vaping flavour ban, 2021–2022
Authors: Schneller Liane M , Reid Jessica L , Kasza Karin A , O'Connor Richard J , Hyland Andrew , Hammond David
Published: July 2024

Significance

Despite an electronic cigarette (e-cigarette) flavour ban in New York (NY) since May 2020, most youth who vape continue to report vaping restricted flavours. This study aims to examine youth awareness and perceived behaviour change associated with the NY vaping flavour ban.

Methods

NY cross-sectional data from 2021 and 2022 ITC Youth Survey were combined and analysed (N=1014). Weighted analyses were used to describe awareness and understanding of the e-cigarette flavour ban, as well as changes in tobacco use behaviour.

Results

Only 0.9% (n=8) of NY youth understood the flavour ban, in that they were both aware of the flavour ban in all stores and accurately reported that all non-tobacco flavours were banned. Awareness and understanding of the flavour ban differed by vaping status (p<0.01): respondents who had vaped in the past 12 months or 30 days were more likely (adjusted OR (aOR)=2.15, 95% CI 1.34, 3.45; aOR=2.07, 95% CI 1.17, 3.64, respectively) to be aware of the flavour ban but misunderstand the stores or flavours included. Of the majority of youth who reported awareness of a flavour ban and vaped (n=122) or smoked (n=78) in the past 12 months reported no changes in behaviour (64.0% and 69.7%, respectively).

Conclusions

Less than one-third of NY youth, regardless of vaping status, reported that an e-cigarette flavour ban was present where they live. Further, most youth who were aware of the ban misunderstood which flavours were restricted and/or that the ban applied to all stores that sold e-cigarettes. Increased enforcement and educational efforts could improve awareness and understanding of the NY e-cigarette flavour ban.
Stability study of coal pillars due to induced stress-driven spalling during development and mechanised depillaring at different depths of cover
Authors: Singh Abhishek Kumar , Ram Sahendra , Kumar Ashok , Waclawik Petr , Kukutsch Radovan
Published: July 2024

Induced stress-driven spalling in coal pillars depends on several factors including depth of cover, in situ stresses, and presence of weak planes. A solid coal pillar generally experiences spalling at a higher depth. Fender and snook/rib experiences considerable spalling during depillaring even at lower depth below strong and massive rock mass. The spalling in pillars leads to instability at working places including goaf encroachment during depillaring. This paper discusses the measurement of induced stress-driven spalling during development of a seam having weak roof–pillar interface at 850–900 m at CSM mine in Czech Republic. Spalling is also examined in different form of coal pillars during mechanized depillaring at 250 m depth at Godavarikhani 11 Incline mine in India. Finite difference based numerical modelling was carried out to assess the behaviour of the pillars. Ultimate non-elastic region was observed up to 9 m near the roof−pillar interface due to presence of weak plane and around 8 m at middle height of the pillar at the higher depth. At the moderate depth of around 250 m, maximum vertical induced stress was observed over a fender. Spalling of 2 and 1.5 m was observed in the fender and pillar, respectively.
A sustainable environment requires sustainable water—a review of some water issues to learn from
Authors: Jiang Albert , McBean Edward , Wang Yi
Published: July 2024

Water sustainability has become one of the most severe issues in the 21st century due to urban population growth and climate change. This paper reviews some of the critical key water issues that need to be considered in the quest for water sustainability for the upcoming decades. The purpose is to recognize the critical circumstances for maintaining water sustainability and send warning signals for regions that have passed the “tipping point” of balancing their water sustainability, while failing to realize restoring sustainability will be extremely difficult. Examples are used to demonstrate situations which, in hindsight, have been initially shown to be effective but highly problematic in the long term. This review considers, amongst others, the example of 1960s India, which shows that an agricultural “success” that started in the 1960s has subsequently become an environmental disaster. Additional issues, including the impacts of dietary adjustments, upstream diversions raising downstream shortfalls, and water transfers from agriculture to urban areas, are used as examples. They demonstrate that lessons must be learned from the past to achieve water sustainability, and adaptive measures must be adopted to help humanity avoid irreversible environmental tragedies. This paper highlights the urgent need for policymakers and stakeholders to proactively promote better water resource management strategies, domestic/international collaborations, and strict water use practice regulations, all of which will contribute to water sustainability and management plans.
THE EFFECT OF EXPERIENTIAL LEARNING ON ENTREPRENEURIAL COMPETENCIES AND BUSINESS PERFORMANCE
Authors: KOAPE MATSHEPO , MAMABOLO ANASTACIA
Published: July 2024

The study’s purpose is to examine the effect of experiential learning on business performance through the mediating role of entrepreneurial competencies. Quantitative research was conducted with 123 entrepreneurs in the business development phase, who were part of a business school’s experiential entrepreneurial program in South Africa. Multiple hierarchical regression analysis revealed that experiential learning led to mastery of entrepreneurial competencies that benefited business performance. Specific competencies played a role as mediators, such as opportunity recognition and market analysis. The findings also suggest that environmental factors such as access to finance shape the mediating role of entrepreneurial competencies on experiential learning and business performance. The study contributes to the entrepreneurship field by looking at experiential learning beyond entrepreneurial intentions to action. In addition, the study demonstrates that experiential learning and its outcomes are influenced by the stage of the business and intended learning outcomes. Therefore, researchers and practitioners should consider entrepreneurial competencies from a multi-dimensional perspective.
EXPLORING THE EFFECT OF CEO ENTREPRENEURIAL ORIENTATION ON TRIPLE BOTTOM LINE PERFORMANCE OF SMEs
Authors: MOHAMMADI SAEED
Published: July 2024

This research investigates individual entrepreneurial orientation and its implications for business performance. Examining dynamic managerial capabilities (DMC) as a mediating factor, this study explores the relationship between CEO entrepreneurial orientation and the triple bottom line performance of businesses. It emphasizes the role of improved managerial capabilities resulting from individual entrepreneurial orientation. Emphasis is placed on the importance of entrepreneurial activities not only in affecting financial performance, but also social and environmental performance. The results reveal a strong and positive correlation between CEOs’ individual entrepreneurial orientation and triple bottom line performance, considering DMC. This confirmation is not only robust based on existing theories, but also provides novel evidence of additional effects of the relationship between CEOs’ individual entrepreneurial orientation and broader approaches to business performance. Moreover, this research contributes to current issues related to entrepreneurship, sustainability and the evolving role of individuals in shaping the future of organizations.
NAVIGATING THE UNKNOWN: HOW HEALTHCARE ENTREPRENEURS MANAGE UNCERTAINTY
Authors: GILSTRAP CRISTINA M. , WEBER THOMAS , GILSTRAP CURT A.
Published: July 2024

Healthcare entrepreneurs (HCEs) develop and implement solutions to improve processes, structures, and practices. Unfortunately, they also operate in environments with multiple levels of uncertainty because of their industry’s unpredictable, nonlinear, and risk-averse features. Moreover, entrepreneurial uncertainty has been underexplored in the healthcare context. This empirical study examines HCEs’ uncertainty management processes throughout the entrepreneurial process. In-depth interviews were conducted with 25 for-profit and social HCEs across nine sectors in nineteen different states within the United States. We used a mixed methods qualitative approach to analyze, interpret and visualize data, including constant comparative and lexical analyses. Interview data reveals HCEs experience five major uncertainties and utilize distinct strategies to manage those uncertainties. Findings highlight the effect of external environmental conditions on HCEs’ uncertainty, the complexity and interconnectedness of HCEs’ uncertainties, their willingness to utilize a wide repertoire of strategies to cope with uncertainty, and communication’s central role in the management process. We provide practical advice to improve educational, training and professional development initiatives for aspiring, novice and experienced HCEs.
A note on Pk-decomposition of the Kneser graph
Authors: Sahai C. Cecily , Kumar S. Sampath , Jose T. Arputha
Published: July 2024

In this note, it is shown that if [Formula: see text]mod [Formula: see text], then the Kneser graph [Formula: see text] is [Formula: see text]-decomposable.
Signless Laplacian energies of non-commuting graphs of finite groups and related results
Authors: Sharma Monalisha , Nath Rajat Kanti
Published: July 2024

The non-commuting graph of a non-abelian group [Formula: see text] with center [Formula: see text] is a simple undirected graph whose vertex set is [Formula: see text] and two vertices [Formula: see text] are adjacent if [Formula: see text]. In this paper, we compute Signless Laplacian spectrum and Signless Laplacian energy of non-commuting graphs of certain finite non-abelian groups. We obtain several conditions such that the non-commuting graph of [Formula: see text] is Q-integral and observe relations between energy, Signless Laplacian energy and Laplacian energy. In addition, we look into the hyperenergetic and hypoenergetic properties of non-commuting graphs of finite groups. We also assess whether the same graphs are Q-hyperenergetic and L-hyperenergetic.
The Ising Model on the Bethe Lattice with Two Atoms Per Site
Authors: Albayrak Erhan
Published: July 2024

The molecular approach of a spin model is constructed on the Bethe lattice (BL), and then it is examined in terms of exact recursion relations. Rather than assuming that each BL site is inhabited by a single spin, each site is occupied by two spin-1/2 atoms A and B, forming a molecule. Each molecule is considered to contain two spin-1/2 atoms, as well as [Formula: see text] or 6 nearest-neighbor molecules. In addition to the internal interactions between the atoms of each molecule, the molecules interact via their atoms in terms of bilinear interaction parameters J. Atoms of a molecule interact with [Formula: see text], while the molecules interact via their atoms in terms of [Formula: see text] and [Formula: see text]. After obtaining the magnetizations of each atom in the central molecule of the BL, the average magnetization of the molecule is determined. It is found that the model presents first-and second-order and random phase transitions. The model also displays tricritical, bicritical and end points, in addition to reentrant behavior for appropriate J values.
An Interview with Tsong Yueh Chen - 2024 SIGSOFT Awardee
Authors: Forti Stefano
Published: July 2024

Tsong Yueh Chen received the 2024 SIGSOFT Outstanding Research Award for contributions to software testing through the invention and development of metamorphic testing. He is currently a Professor of Software Engineering at the Department of Computer Science and Software Engineering, Swinburne University of Technology, Australia. Previously, he pursued a PhD degree from the University of Melbourne and an MSc degree and DIC from the Imperial College of Science and Technology, London, U.K. Before joining Swinburne University of Technology, he has lectured at The University of Hong Kong and The University of Melbourne. His research interests fall within the area of software engineering, with a focus on software analysis and testing, debugging, and program repair. He invented adaptive random testing and metamorphic testing. In 2021, the article he co-authored on "Adaptive Random Testing: The ART of test case diversity" (2010) was awarded with the Grand Champion of the Most Influential Paper Award of the "Journal of Systems and Software".
The 13th International Workshop on Genetic Improvement(GI @ ICSE 2024)
Authors: Langdon William B. , An Gabin , Blot Aymeric , Nowack Vesna , Petke Justyna , Yoo Shin , Krauss Oliver , Fredericks Erik M. , Blackwell Daniel
Published: July 2024

The GI @ ICSE 2024 workshop, held 16 April, in addition to presentations, contained a keynote on how to use Genetic Improvement to control deep AI large language models in software engineering and a tutorial on a language independent tool for GI research. We summarise these, the papers, people, prizes, acknowledgements, discussions and hopes for the future.
Lightweight Champions of the World: Side-Channel Resistant Open Hardware for Finalists in the NIST Lightweight Cryptography Standardization Process
Authors: Mohajerani Kamyar , Beckwith Luke , Abdulgadir Abubakr , Kaps Jens-Peter , Gaj Kris
Published: July 2024

Cryptographic competitions played a significant role in stimulating the development and release of open hardware for cryptography. The primary reason was the focus of standardization organizations and other contest organizers on transparency and fairness of hardware benchmarking, which could be achieved only with all source code made available for public scrutiny. Consequently, the number and quality of open-source hardware implementations developed during subsequent major competitions, such as AES, SHA-3, and CAESAR, have steadily increased. However, most of these implementations were still quite far from being used in future products due to the lack of countermeasures against side-channel analysis (SCA). In this paper, we discuss the first coordinated effort at developing SCA-resistant open hardware for all finalists of a cryptographic standardization process. The developed hardware is then evaluated by independent labs for information leakage and resilience to selected attacks. Our target included the ten finalists of the NIST Lightweight Cryptography Standardization Process. The authors’ contributions included formulating detailed requirements, publicizing the submissions, matching open hardware with suitable SCA-evaluation labs, developing a subset of all implementations, serving as one of the six evaluation labs, performing FPGA benchmarking of all protected and unprotected implementations, and summarizing results in the comprehensive report. Our results confirm that NIST made the right decision in selecting Ascon as a future lightweight cryptography standard. They also indicate that at least three other algorithms, Xoodyak, TinyJAMBU, and ISAP, were very strong competitors and outperformed Ascon in at least one of the evaluated performance metrics.
Can GitHub Issues Help in App Review Classifications?
Authors: Abedini Yasaman , Heydarnoori Abbas
Published: July 2024

App reviews reflect various user requirements that can aid in planning maintenance tasks. Recently, proposed approaches for automatically classifying user reviews rely on machine learning algorithms. A previous study demonstrated that models trained on existing labeled datasets exhibit poor performance when predicting new ones. Therefore, a comprehensive labeled dataset is essential to train a more precise model. In this paper, we propose a novel approach that assists in augmenting labeled datasets by utilizing information extracted from an additional source, GitHub issues, that contains valuable information about user requirements. First, we identify issues concerning review intentions (bug reports, feature requests, and others) by examining the issue labels. Then, we analyze issue bodies and define 19 language patterns for extracting targeted information. Finally, we augment the manually labeled review dataset with a subset of processed issues through the
Within-App
,
Within-Context
, and
Between-App Analysis
methods. We conducted several experiments to evaluate the proposed approach. Our results demonstrate that using labeled issues for data augmentation can improve the F1-score to 6.3 in bug reports and 7.2 in feature requests. Furthermore, we identify an effective range of 0.3 to 0.7 for the auxiliary volume, which provides better performance improvements.
ω-Regular Energy Problems
Authors: Dziadek Sven , Fahrenberg Uli , Schlehuber Philipp
Published: July 2024

We show how to efficiently solve problems involving a quantitative measure, here called
energy
, as well as a qualitative acceptance condition, expressed as a Büchi or Parity objective, in finite weighted automata and in one-clock weighted timed automata. Solving the former problem and extracting the corresponding witness is our main contribution and is handled by a modified version of the Bellman-Ford algorithm interleaved with Couvreur’s algorithm. The latter problem is handled via a reduction to the former relying on the corner-point abstraction. All our algorithms are freely available and implemented in a tool based on the open-source platforms TChecker and Spot.
The Future of Nanotechnology-Driven Electrochemical and Electrical Point-of-Care Devices and Diagnostic Tests
Authors: Boukherroub Rabah , Szunerits Sabine
Published: July 2024

Point-of-care (POC) devices have become rising stars in the biosensing field, aiming at prognosis and diagnosis of diseases with a positive impact on the patient but also on healthcare and social care systems. Putting the patient at the center of interest requires the implementation of noninvasive technologies for collecting biofluids and the development of wearable platforms with integrated artificial intelligence–based tools for improved analytical accuracy and wireless readout technologies. Many electrical and electrochemical transducer technologies have been proposed for POC-based sensing, but several necessitate further development before being widely deployable. This review focuses on recent innovations in electrochemical and electrical biosensors and their growth opportunities for nanotechnology-driven multidisciplinary approaches. With a focus on analytical aspects to pave the way for future electrical/electrochemical diagnostics tests, current limitations and drawbacks as well as directions for future developments are highlighted.
Sexuality Discourses: Indexical Misrecognition and the Politics of Sex
Authors: Barrett Rusty , Hall Kira
Published: July 2024

This review of research on sexuality discourses directs attention to the patterns of indexical disalignment that have facilitated the global rise of transphobic, homophobic, and misogynist discourses. Over the last two decades, scholarship in the area of language and sexuality has focused primarily on patterns of alignment in the community-based indexical production of social personae, a necessary move for establishing the discursive agency, and indeed humanity, of LGBTQ+ groups. The focus of this review, however, is not alignment but disalignment, for it is in the clash of indexical systems that sexual ideologies take root. Specifically, the article focuses on acts of misrecognition that arise at the boundaries of indexical meaning, identifying practices such as indexical inoculation, indexical presumption, and indexical denial. The review is designed to provoke future research on misrecognition as contextualized social practice, a turn we believe imperative for uncovering the power-laden infrastructure of sexuality discourses.
Molecular Recognition of VSIG1 in Biological Samples for Fast Diagnosis of Gastric Cancer
Authors: Stefan-van Staden Raluca-Ioana , Gheorghe Damaris-Cristina , Ilie-Mihai Ruxandra-Maria
Published: July 2024

VSIG1 is a new biomarker member of the JAM family relevant in gastric cancer diagnostics. Due to its detection and quantification impact for fast and early diagnosis of gastric cancer, two types of intelligent miniplatforms based on stochastic sensors as detection tools, were designed and validated using real samples. A 3D stochastic microsensor based on Nitrogen and Sulfur dopped graphene paste modified with calix[4]arene-25,26,27,28-tetrol, and a 2D disposable screen-printed stochastic sensor based on thin film gold modified with calix[4]arene-25,26,27,28-tetrol were constructed and inserted as working sensors into the miniplatforms. The proposed intelligent miniplatforms shown sensitivities as high as 1.12 × 1010 s−1g−1ml, limits of determination of 1 × 10−23g ml−1, and working concentration ranges between 1 × 10−23 and 1 × 10−8 g ml−1. Recoveries higher than 99.30% with % RSD values lower than 0.05% were obtained when used for screening test of biological samples, for VSIG1.
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct
Authors: Deshpande Venkatesh , Park Euijung , Jayatissa Nipun U. , Khan Shaza , Mejia Raymond , Yang Chin-Rang , Chou Chung-Lin , Raghuram Viswanathan , Knepper Mark A.
Published: July 2024

Vasopressin regulates water transport in the renal collecting duct in part through phosphorylation or dephosphorylation of proteins that regulate aquaporin-2. Prior studies have identified 51 vasopressin-regulated phosphorylation sites in 45 proteins. This study uses Bayesian data integration techniques to combine information from multiple prior proteomics and transcriptomics studies to predict the protein kinases that phosphorylate the 51 sites. Most of the regulated sites were predicted to be phosphorylated by protein kinase A or ERK1/ERK2.
Characterising Potential Subtypes and Influencing Factors of Sleep Quality in Psychiatric Nurses by Latent Profile Analysis
Authors: Pan Xiaoshi , Wang Jiayi , Zhang Ke , Yang Chenxin , Tang Minghong , Feng Zhaoxin , Liu Li , Wu Hui
Published: July 2024

Background. Sleep is a crucial factor affecting an individual’s physical and mental health. Psychiatric nurses work under high stress and load, and it is necessary to understand the sleep quality of psychiatric nurses and the influencing factors. However, individual‐centred studies of psychiatric nurses’ sleep are limited. Aims. To explore the heterogeneity in sleep quality among psychiatric nurses, to identify the factors influencing different subtypes, and to provide targeted strategies and measures to improve their sleep quality. Methods. From August to October 2022, 298 psychiatric nurses working in a mental health centre in Liaoning Province were selected as the participants. The study involved administering the following two questionnaires: the general information questionnaire and the Pittsburgh Sleep Quality Index (PSQI). Data analyses included latent profile analysis, Kruskal–Wallis H test, and multiple logistic regression. Results. The prevalence of poor sleep quality (PSQI >5) among psychiatric nurses was 54.7%. The sleep quality of psychiatric nurses could be classified into the following three distinct profiles: good sleep quality, moderate sleep quality, and poor sleep quality. Nurses who were over 40 years of age, unmarried/divorced/separated/widowed, worked more than 40 hours per week, experienced significant life events in the past year, had poor nurse‐patient relationships, and had chronic diseases were more likely to have poorer sleep quality. Conclusions. There was significant heterogeneity in sleep quality among psychiatric nurses. Age, marital status, work schedule, total weekly working hours, night shifts, special life events, nurse‐patient relationships, and chronic diseases were associated with their sleep quality. Implications. The heterogeneity and influencing factors of sleep quality in psychiatric nurses provided evidence for individualized interventions in the future. This trial is registered with ChiCTR2200062347.
Effects of Binaural Beat Music Integrated with Rhythmical Photic Stimulation on Anxiety Reduction among Healthy Daycare Center Staff
Authors: Liu Cheng , Yang Shang-Yu , Wang Jiun-Yi
Published: July 2024

This study investigated the efficacy of combining binaural beat music (BBM) with rhythmical photic stimulation at the α frequency in alleviating anxiety among daycare staff and explored its impacts on daycare staff with different anxiety levels. A quasi‐experimental research design was adopted, which included three interventions: BBM, BBM integrated with rhythmical photic stimulation, and relaxation music (control group). Participants completed a questionnaire prior to the first intervention, which included personal demographic information and the Beck Anxiety Inventory. The effects of these interventions on anxiety relief among daycare staff were evaluated through heart rate variability (HRV), brain waves, and blood pressure before and after the interventions. Statistical analysis primarily employed the Friedman test to analyze the differences in changes in HRV, brain waves, and blood pressure before and after the interventions. A total of 40 individuals participated in this study (16 males and 24 females), with an average age of 31.73 ± 8.83 years. The results showed that, compared to BBM alone, BBM integrated with rhythmical photic stimulation significantly reduced the normalized low/high frequency (nLF/nHF) ratio in participants with moderate anxiety (p < 0.05). The results suggest that BBM integrated with rhythmical photic stimulation may serve as an intervention for the prevention and relief of anxiety by regulating an individual’s autonomic nervous system. However, further research is required to confirm these findings.
Influence of α‐MnO2 and Curing Temperature on Density and Microhardness of Epoxy Nanocomposites
Authors: Hussain Md Zakir , Sarmah Pranjal , Yadav Surendra Kumar , Kumar Virendra , Yadav Ashu , Goyal Ashish , Oza Ankit D. , Prakash Chander , Khanna Virat
Published: July 2024

α‐MnO2/epoxy nanocomposite shows great potential for structural and tribological applications. The properties of epoxy nanocomposites depended on weight percent (wt.%) loading of reinforcement material and curing temperature. Therefore, the current study examines how neat epoxy’s density and microhardness were affected by the weight percent (0.5, 0.75, and 1.0 wt. %) loading of nano α‐MnO2 and curing temperatures (24°C, 50°C, 80°C, 100°C, and 140°C). The samples were created using a procedure called the solution mixing method. Phase and surface morphology of the nanocomposite were analyzed by X‐ray diffraction and scanning electron microscopy, respectively. The density of the samples was measured using mass and volume relationship. Density analysis indicated that the density of the nanocomposite increased with increasing wt.% loading of α‐MnO2 and decreasing with curing temperature. According to the microhardness study, the nanocomposite samples exhibited lower microhardness with higher wt.% loading of α‐MnO2 and an increasing curing temperature. At the indentation load, however, none of the samples developed indentation fractures. The probability plot of the microhardness data at the 95% confidence level showed that the sample’s hardness statistics were unaffected by load and the position of the indentation mark. Analysis of variance results indicated that the wt.% loading of α‐MnO2 had a significant effect on the density and microhardness of the nanocomposite, with contributions of 77.7% and 74.75%, respectively, and the effect of curing temperature was small compared to the loading of α‐MnO2. The results also indicated that the optimal loading of α‐MnO2 in epoxy was 0.5 wt.% and optimal curing temperature at room temperature.
CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/β-Catenin Signaling to Inhibit EZH2-Driven EMT
Authors: Gonzalez Maria E. , Brophy Bryce , Eido Ahmad , Leonetti Adele E. , Djomehri Sabra I. , Augimeri Giuseppina , Carruthers Nicholas J. , Cavalcante Raymond G. , Giordano Francesca , Andò Sebastiano , Nesvizhskii Alexey I. , Fearon Eric R. , Kleer Celina G.
Published: July 2024

Metaplastic breast carcinomas (mBrCA) are a highly aggressive subtype of triple-negative breast cancer with histologic evidence of epithelial-to-mesenchymal transition and aberrant differentiation. Inactivation of the tumor suppressor gene cellular communication network factor 6 (CCN6; also known as Wnt1-induced secreted protein 3) is a feature of mBrCAs, and mice with conditional inactivation of Ccn6 in mammary epithelium (Ccn6-KO) develop spindle mBrCAs with epithelial-to-mesenchymal transition. Elucidation of the precise mechanistic details of how CCN6 acts as a tumor suppressor in mBrCA could help identify improved treatment strategies. In this study, we showed that CCN6 interacts with the Wnt receptor FZD8 and coreceptor LRP6 on mBrCA cells to antagonize Wnt-induced activation of β-catenin/TCF-mediated transcription. The histone methyltransferase EZH2 was identified as a β-catenin/TCF transcriptional target in Ccn6-KO mBrCA cells. Inhibiting Wnt/β-catenin/TCF signaling in Ccn6-KO mBrCA cells led to reduced EZH2 expression, decreased histone H3 lysine 27 trimethylation, and deregulation of specific target genes. Pharmacologic inhibition of EZH2 reduced growth and metastasis of Ccn6-KO mBrCA mammary tumors in vivo. Low CCN6 is significantly associated with activated β-catenin and high EZH2 in human spindle mBrCAs compared with other subtypes. Collectively, these findings establish CCN6 as a key negative regulator of a β-catenin/TCF/EZH2 axis and highlight the inhibition of β-catenin or EZH2 as a potential therapeutic approach for patients with spindle mBrCAs.

 Significance: CCN6 deficiency drives metaplastic breast carcinoma growth and metastasis by increasing Wnt/β-catenin activation to upregulate EZH2, identifying EZH2 inhibition as a mechanistically guided treatment strategy for this deadly form of breast cancer.
Therapeutic Targeting of the GLS1–c-Myc Positive Feedback Loop Suppresses Glutaminolysis and Inhibits Progression of Head and Neck Cancer
Authors: Yang Jianqiang , Chen Fanghui , Lang Liwei , Yang Fan , Fu Zhenzhen , Martinez Juan , Cho Amber , Saba Nabil F. , Teng Yong
Published: July 2024

Head and neck squamous cell carcinoma (HNSCC) is addicted to glutaminolysis. Targeting this metabolic dependency has emerged as a potential therapeutic approach for HNSCC. In this study, we conducted a bioinformatic analysis of The Cancer Genome Atlas HNSCC cohort that revealed a robust correlation between expression of MYC (encoding the protein c-Myc) and glutaminase 1 (GLS1), which catalyzes the first step in glutaminolysis. Intriguingly, disruption of GLS1 signaling in HNSCC cells by genetic depletion or CB-839 treatment resulted in a reduction in c-Myc protein stability via a ubiquitin-specific peptidase 1–dependent ubiquitin–proteasome pathway. On the other hand, c-Myc directly binds to the promoter region of GLS1 and upregulates its transcription. Notably, the GLS1–c-Myc pathway enhanced acetyl-coenzyme A carboxylase–dependent Slug acetylation, prompting cancer cell invasion and metastasis. Thus, the GLS1–c-Myc axis emerged as a positive feedback loop critical for driving the aggressiveness of HNSCC. Therapeutically, combining CB-839 with the c-Myc inhibitor MYCi975 strongly suppressed GLS1–c-Myc signaling, resulting in a superior antitumor effect compared with either single agent in an orthotopic mouse model of HNSCC. These findings hold promise for the development of effective therapies for patients with HNSCC, addressing an urgent need arising from the significant incidence and high metastatic rate of the disease.

Significance: GLS1 and c-Myc form a positive feedback loop that promotes head and neck cancer metastasis and can be targeted as a promising therapeutic strategy for this disease.
Supplementary Table 5 from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: July 2024

Supplementary Table 5
Supplementary Figure 2 from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: July 2024

Supplementary Figure 2
Supplementary Figure 1 from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: July 2024

Supplementary Figure 1
Figure 4 from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: July 2024

Stratification of survival outcomes by pCR by RFS (A) and OS (B).
Notice of Retraction: The Investment Risk Effect of Stock Returns In LQ-45 Index Companies on Foreign and Domestic Investors
Authors: Sari Pristin Prima , Hermuningsih Sri , Prajnanta Final , Rahmawati Anisya Dewi
Published: July 2024

This article has been retracted by the publisher.
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This article has been retracted at the request of the Authors. The editors and authors have jointly made the decision to retract the paper. Reasonable effort should be made to remove references to this paper.
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Foreign and domestic investors may have an impact on changes in LQ-45 stock returns on the Indonesia stock exchange. The impact given by foreign and domestic investors can be negative or positive for the capital market. The purpose of this study was to find empirical evidence of the effect of systematic risk by foreign and domestic investors on changes in stock returns. The research method uses quantitative methods from the stock trading reports of LQ-45 companies.  The data is processed using the IBM 25 SPSS statistical tool. The population in this study is the stock return of LQ-45 companies listed on the Indonesia Stock Exchange. Sample data is the stock return of the LQ-45 Companies on January 2, 2020-2023. The novelty of the study is the systematic risk variable, which is the driving force to moderate the influence of foreign and domestic investors on stock returns. The results of the study showed that the systematic risk variable had a negative effect on stock returns, foreign investors had no effect on stock returns, and domestic investors had a positive effect on stock returns. The amount of low systematic risk can affect the increase in stock returns. The number of domestic investors can affect the increase in stock returns. The study could have practical implications for investors, regulators, policymakers, and academics by providing empirical evidence and insights into the interplay between systematic risk, investor types (foreign and domestic), and stock returns in the Indonesian capital market.
PRADOC: A Multicenter Randomized Controlled Trial to Assess the Efficiency of PRADO‐IC, a Nationwide Pragmatic Transition Care Management Plan for Hospitalized Patients With Heart Failure in France
Authors: Roubille François , Labarre Jean‐Philippe , Georger Frédéric , Galinier Michel , Herman Fanchon , Berdague Philippe , Nogue Erika , Petroni Thibaut , Delbaere Quentin , Malak Alexandre , Robin Marie , Prunet Elvira , Leclercq Florence , Pasquie Jean‐Luc , Papinaud Laurence , Mercier Grégoire , Ricci Jean‐Etienne , Cayla Guillaume , Duflos Claire
Published: July 2024

Background

The PRADO‐IC (Programme de Retour à Domicile après une Insuffisance Cardiaque) is a transition care program designed to improve the coordination of care between hospital and home that was generalized in France in 2014. The PRADO‐IC consists of an administrative assistant who visits patients during hospitalization to schedule follow‐up visits. The aim of the present study was to evaluate the PRADO‐IC program based on the hypotheses provided by health authorities.

Methods and Results

The PRADOC study is a multicenter, controlled, randomized, open‐label, mixed‐method trial of the transition program PRADO‐IC versus usual management in patients hospitalized with heart failure (standard of care group; NCT03396081). A total of 404 patients were recruited between April 2018 and May 2021. The mean patient age was 75 years (±12 years) in both groups. The 2 groups were well balanced regarding severity indices. At discharge, patients homogeneously received the recommended drugs. There was no difference between groups regarding hospitalizations for acute heart failure at 1 year, with 24.60% in the standard of care group and 25.40% in the PRADO‐IC group during the year following the index hospitalization (hazard ratio, 1.04 [95% CI, 0.69–1.56];
P
=0.85) or cardiovascular mortality (hazard ratio, 0.67 [95% CI, 0.34–1.31];
P
=0.24).

Conclusions

The PRADO‐IC has not significantly improved clinical outcomes, though a trend toward reduced cardiovascular mortality is evident. These results will help in understanding how transitional care programs remain to be integrated in pathways of current patients, including telemonitoring, and to better tailor individualized approaches.

REGISTRATION

URL:
https://www.clinicaltrials.gov
; Unique Identifier: NCT03396081.
Vascular Aging in Ischemic Stroke
Authors: Liu Lian , Zhao Bo , Yu Yueyang , Gao Wenwei , Liu Weitu , Chen Lili , Xia Zhongyuan , Cao Quan
Published: July 2024

Cellular senescence, a permanent halt in cell division due to stress, spurs functional and structural changes, contributing to vascular aging characterized by endothelial dysfunction and vascular remodeling. This process raises the risk of ischemic stroke (IS) in older individuals, with its mechanisms still not completely understood despite ongoing research efforts. In this review, we have analyzed the impact of vascular aging on increasing susceptibility and exacerbating the pathology of IS. We have emphasized the detrimental effects of endothelial dysfunction and vascular remodeling influenced by oxidative stress and inflammatory response on vascular aging and IS. Our goal is to aid the understanding of vascular aging and IS pathogenesis, particularly benefiting older adults with high risk of IS.
Saliva, Plasma, and Multifluid Metabolomic Signatures of Periodontal Disease, Type 2 Diabetes Progression, and Markers of Glycemia and Dyslipidemia Among Puerto Rican Adults With Overweight and Obesity
Authors: Wang Zicheng , Haslam Danielle E. , Sawicki Caleigh M. , Rivas‐Tumanyan Sona , Hu Frank B. , Liang Liming , Wong David T. W. , Joshipura Kaumudi J. , Bhupathiraju Shilpa N.
Published: July 2024

Background

Evidence from cohort studies indicates a bidirectional relationship between periodontal disease and type 2 diabetes (T2D), but the underlying mechanisms remain unknown. In this study, we aimed to (1) identify saliva, plasma, and multifluid metabolomic signatures associated with periodontal disease and (2) determine if these signatures predict T2D progression and cardiometabolic biomarkers at year 3.

Methods and Results

We included participants from the SOALS (San Juan Overweight Adult Longitudinal Study) (n=911). Metabolites from saliva (k=635) and plasma (k=1051) were quantified using liquid chromatography–mass spectrometry. We applied elastic net regression with 10‐fold cross‐validation to identify baseline metabolomic signatures of periodontal disease. Multivariable Cox proportional hazards regression and linear regression were used to evaluate the association with T2D progression and biomarker concentrations. Metabolomic profiles included highly weighted metabolites related to lysine and pyrimidine metabolism. Periodontal disease or its 3 metabolomic signatures were not associated with T2D progression in 3 years. Prospectively, 1‐SD increments in the multifluid and saliva metabolomic signatures were associated with higher low‐density lipoprotein (multifluid: 12.9±5.70,
P
=0.02; saliva: 13.3±5.11,
P
=0.009). A 1‐SD increment in the plasma metabolomic signature was also associated with Homeostatic Model Assessment for Insulin Resistance (2.67±1.14,
P
=0.02) and triglyceride (0.52±0.18,
P
=0.002).

Conclusions

Although metabolomic signatures of periodontal disease could not predict T2D progression, they were associated with low‐density lipoprotein, triglyceride, and Homeostatic Model Assessment for Insulin Resistance levels at year 3.